# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- PWI PF01480.12 EWC43382.1 - 3.4e-09 36.6 1.5 1e-08 35.1 0.0 2.2 2 0 0 2 2 2 1 PWI domain RRM_6 PF14259.1 EWC43382.1 - 4.6e-07 29.7 0.0 1.7e-06 27.8 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 EWC43382.1 - 2.1e-06 27.2 0.0 6.6e-06 25.6 0.0 1.9 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH PF00642.19 EWC43382.1 - 8.8e-06 25.2 3.1 1.6e-05 24.4 2.1 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_5 PF13893.1 EWC43382.1 - 0.00021 21.0 0.0 0.00042 20.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 EWC43382.1 - 0.00022 20.9 0.0 0.031 14.0 0.0 2.4 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif DUF1330 PF07045.6 EWC43382.1 - 0.0035 17.1 0.0 2 8.3 0.0 2.7 2 0 0 2 2 2 2 Protein of unknown function (DUF1330) RRM_3 PF08777.6 EWC43382.1 - 0.11 12.3 0.0 0.11 12.3 0.0 2.7 2 0 0 2 2 2 0 RNA binding motif OmpH PF03938.9 EWC43382.1 - 4.8 7.1 20.4 11 5.9 14.2 1.6 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Borrelia_P83 PF05262.6 EWC43382.1 - 9 4.4 22.0 16 3.6 15.2 1.3 1 0 0 1 1 1 0 Borrelia P83/100 protein GTP_EFTU PF00009.22 EWC43383.1 - 4.2e-32 111.0 0.0 4.2e-32 111.0 0.0 2.5 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain IF-2 PF11987.3 EWC43383.1 - 3.3e-18 65.5 0.0 8.9e-18 64.1 0.0 1.8 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.20 EWC43383.1 - 1.6e-11 44.1 8.9 3.4e-10 39.8 0.1 3.7 3 0 0 3 3 3 2 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 EWC43383.1 - 1.2e-06 28.4 0.1 4.5e-06 26.5 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase Miro PF08477.8 EWC43383.1 - 0.0019 18.6 0.0 0.0085 16.5 0.0 2.2 1 0 0 1 1 1 1 Miro-like protein ATP_bind_1 PF03029.12 EWC43383.1 - 0.0024 17.4 0.0 0.0059 16.1 0.0 1.7 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_22 PF13401.1 EWC43383.1 - 0.011 15.8 0.0 0.048 13.8 0.0 2.1 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.1 EWC43383.1 - 0.12 12.3 0.0 0.12 12.3 0.0 3.5 2 1 0 2 2 2 0 AAA ATPase domain Peptidase_S64 PF08192.6 EWC43384.1 - 0.02 13.2 0.1 0.046 12.0 0.0 1.5 2 0 0 2 2 2 0 Peptidase family S64 Abhydrolase_6 PF12697.2 EWC43385.1 - 2.8e-23 82.9 1.6 4.4e-23 82.3 1.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EWC43385.1 - 9.8e-15 54.7 0.1 2e-14 53.7 0.1 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EWC43385.1 - 6.1e-14 51.9 0.0 1.1e-13 51.2 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.15 EWC43385.1 - 3.7e-06 26.5 0.0 5.9e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Hydrolase_4 PF12146.3 EWC43385.1 - 7.2e-05 22.5 0.1 0.00047 19.9 0.0 2.1 2 0 0 2 2 2 1 Putative lysophospholipase Thioesterase PF00975.15 EWC43385.1 - 0.0019 18.4 0.3 0.34 11.0 0.1 2.4 2 1 0 2 2 2 1 Thioesterase domain Lipase_3 PF01764.20 EWC43385.1 - 0.0052 16.4 0.0 0.014 15.0 0.0 1.7 2 0 0 2 2 2 1 Lipase (class 3) Chlorophyllase2 PF12740.2 EWC43385.1 - 0.0071 15.2 0.0 0.011 14.6 0.0 1.3 1 0 0 1 1 1 1 Chlorophyllase enzyme Abhydrolase_3 PF07859.8 EWC43385.1 - 0.0075 15.8 0.0 0.014 14.9 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Ndr PF03096.9 EWC43385.1 - 0.012 14.1 0.0 0.018 13.5 0.0 1.2 1 0 0 1 1 1 0 Ndr family DUF2305 PF10230.4 EWC43385.1 - 0.033 13.5 0.0 0.056 12.8 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2305) Chlorophyllase PF07224.6 EWC43385.1 - 0.059 12.1 0.0 0.077 11.7 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase DUF915 PF06028.6 EWC43385.1 - 0.066 12.3 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) DUF2974 PF11187.3 EWC43385.1 - 0.076 12.3 0.0 0.12 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Ser_hydrolase PF06821.8 EWC43385.1 - 0.095 12.3 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase Nop PF01798.13 EWC43386.1 - 2e-29 101.8 0.1 3.6e-29 100.9 0.1 1.4 1 0 0 1 1 1 1 Putative snoRNA binding domain NOSIC PF08060.8 EWC43386.1 - 2.5e-20 72.0 0.3 5.8e-20 70.8 0.2 1.7 1 0 0 1 1 1 1 NOSIC (NUC001) domain SUZ PF12752.2 EWC43387.1 - 4.3e-06 27.1 8.5 4.3e-06 27.1 5.9 2.9 2 0 0 2 2 2 1 SUZ domain Fe_hyd_lg_C PF02906.9 EWC43388.1 - 1.6e-57 194.9 0.0 3.2e-57 193.9 0.0 1.5 1 0 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain Arb1 PF09692.5 EWC43390.1 - 2.2e-84 283.6 0.0 3.2e-82 276.4 0.0 2.0 1 1 0 1 1 1 1 Argonaute siRNA chaperone (ARC) complex subunit Arb1 IPK PF03770.11 EWC43391.1 - 1.3e-57 194.6 0.0 1.5e-57 194.4 0.0 1.1 1 0 0 1 1 1 1 Inositol polyphosphate kinase Nucleo_P87 PF07267.6 EWC43391.1 - 0.054 12.1 1.5 0.071 11.7 1.0 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 RXT2_N PF08595.6 EWC43391.1 - 0.091 12.5 2.7 0.14 11.9 1.9 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal Sigma70_ner PF04546.8 EWC43391.1 - 0.3 10.6 6.3 0.43 10.1 4.4 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region PBP1_TM PF14812.1 EWC43391.1 - 0.51 10.6 8.1 0.92 9.8 5.6 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Sporozoite_P67 PF05642.6 EWC43391.1 - 1.1 6.9 3.1 1.6 6.5 2.1 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen CENP-B_dimeris PF09026.5 EWC43391.1 - 3 8.1 8.8 6.3 7.1 6.1 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Het-C PF07217.6 EWC43392.1 - 1e-244 813.3 0.0 1.8e-244 812.5 0.0 1.3 1 0 0 1 1 1 1 Heterokaryon incompatibility protein Het-C Herpes_TAF50 PF03326.8 EWC43392.1 - 0.069 12.0 0.0 0.11 11.4 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus transcription activation factor (transactivator) MIP-T3 PF10243.4 EWC43392.1 - 3.3 6.0 36.5 5.7 5.2 25.3 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Hid1 PF12722.2 EWC43393.1 - 5.9e-239 795.2 0.1 3.4e-238 792.7 0.0 1.9 1 1 0 1 1 1 1 High-temperature-induced dauer-formation protein Dymeclin PF09742.4 EWC43393.1 - 1.9e-85 287.3 0.1 2.6e-85 286.9 0.0 1.1 1 0 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein RDM PF11002.3 EWC43393.1 - 0.077 12.6 0.9 0.18 11.4 0.6 1.6 1 0 0 1 1 1 0 RFPL defining motif (RDM) tRNA-synt_1c PF00749.16 EWC43394.1 - 4.5e-106 354.0 0.0 5.9e-106 353.6 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.13 EWC43394.1 - 9.4e-38 129.6 0.0 1.5e-37 128.9 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain GST_C_3 PF14497.1 EWC43394.1 - 1.9e-07 31.4 0.0 5.8e-07 29.9 0.0 1.9 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 EWC43394.1 - 8e-06 25.6 0.0 3.1e-05 23.7 0.0 2.0 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 EWC43394.1 - 0.0011 18.9 0.0 0.0032 17.4 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Glycogen_syn PF05693.8 EWC43395.1 - 0 1123.3 0.0 0 1123.1 0.0 1.0 1 0 0 1 1 1 1 Glycogen synthase Glycos_transf_1 PF00534.15 EWC43395.1 - 3.2e-06 26.6 0.0 0.0062 15.9 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_transf_5 PF08323.6 EWC43395.1 - 3e-05 23.6 0.5 6.5e-05 22.5 0.3 1.5 1 0 0 1 1 1 1 Starch synthase catalytic domain Glyco_trans_4_4 PF13579.1 EWC43395.1 - 0.00032 20.8 3.6 0.00071 19.7 2.5 1.7 1 1 0 1 1 1 1 Glycosyl transferase 4-like domain Oxidored_molyb PF00174.14 EWC43396.1 - 2.5e-52 176.7 0.0 4e-52 176.0 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.11 EWC43396.1 - 7e-21 74.2 0.1 1.5e-20 73.1 0.0 1.4 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain CTP_transf_2 PF01467.21 EWC43397.1 - 2.8e-22 79.4 0.0 4.1e-22 78.9 0.0 1.2 1 0 0 1 1 1 1 Cytidylyltransferase Mnd1 PF03962.10 EWC43397.1 - 0.12 12.0 0.0 0.18 11.4 0.0 1.2 1 0 0 1 1 1 0 Mnd1 family Glyco_transf_15 PF01793.11 EWC43398.1 - 1.4e-134 448.2 7.2 1.6e-134 448.0 5.0 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Spc97_Spc98 PF04130.8 EWC43399.1 - 3e-47 161.1 0.0 1.4e-36 126.0 0.0 3.2 1 1 1 2 2 2 2 Spc97 / Spc98 family GCP5-Mod21 PF14609.1 EWC43399.1 - 1.1e-08 33.6 0.1 2.4e-08 32.5 0.0 1.6 1 0 0 1 1 1 1 gamma-Tubulin ring complex non-core subunit mod21 Pkinase PF00069.20 EWC43400.1 - 2.4e-17 62.9 0.0 2.8e-17 62.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC43400.1 - 1.9e-14 53.3 0.0 2.2e-14 53.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Mucin PF01456.12 EWC43400.1 - 4.9 6.9 17.0 6.8 6.4 11.8 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein Pkinase PF00069.20 EWC43401.1 - 4.5e-32 111.2 0.0 7.3e-32 110.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC43401.1 - 8.3e-20 70.9 0.0 1.2e-19 70.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EWC43401.1 - 0.0023 16.9 0.0 0.0038 16.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like TPR_10 PF13374.1 EWC43402.1 - 0.11 12.4 0.8 0.48 10.4 0.1 2.0 1 1 1 2 2 2 0 Tetratricopeptide repeat SUI1 PF01253.17 EWC43403.1 - 1.5e-14 53.5 0.1 3e-14 52.5 0.1 1.5 1 0 0 1 1 1 1 Translation initiation factor SUI1 Sporozoite_P67 PF05642.6 EWC43403.1 - 0.029 12.2 1.3 0.034 12.0 0.9 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen HIG_1_N PF04588.8 EWC43404.1 - 1.8e-08 33.9 1.5 4.1e-08 32.8 1.0 1.6 1 0 0 1 1 1 1 Hypoxia induced protein conserved region RNase_H PF00075.19 EWC43405.1 - 4.9e-30 104.5 0.0 9.5e-30 103.6 0.0 1.4 1 0 0 1 1 1 1 RNase H Cauli_VI PF01693.11 EWC43405.1 - 7.3e-30 102.7 6.6 1e-14 54.2 0.2 2.7 2 0 0 2 2 2 2 Caulimovirus viroplasmin FA_desaturase PF00487.19 EWC43405.1 - 5.8e-23 81.6 19.2 1e-22 80.8 13.3 1.3 1 0 0 1 1 1 1 Fatty acid desaturase DUF3474 PF11960.3 EWC43405.1 - 1e-06 28.7 0.0 2.3e-06 27.6 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3474) DUF796 PF05638.7 EWC43405.1 - 0.098 12.6 0.3 0.38 10.7 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF796) RVT_3 PF13456.1 EWC43405.1 - 0.13 12.0 0.0 1 9.1 0.0 2.3 1 1 0 1 1 1 0 Reverse transcriptase-like 4HBT_2 PF13279.1 EWC43406.1 - 7.5e-09 36.0 0.0 1.3e-08 35.3 0.0 1.3 1 0 0 1 1 1 1 Thioesterase-like superfamily FMN_dh PF01070.13 EWC43407.1 - 8.2e-30 103.8 0.9 9.5e-30 103.6 0.6 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Glu_synthase PF01645.12 EWC43407.1 - 6.4e-07 28.6 0.1 9.6e-07 28.0 0.1 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.20 EWC43407.1 - 1.1e-05 24.5 0.9 3.9e-05 22.7 0.3 1.8 1 1 1 2 2 2 1 IMP dehydrogenase / GMP reductase domain His_biosynth PF00977.16 EWC43407.1 - 0.0019 17.4 0.0 0.0022 17.3 0.0 1.2 1 0 0 1 1 1 1 Histidine biosynthesis protein NMO PF03060.10 EWC43407.1 - 0.0069 15.5 0.2 0.0092 15.1 0.1 1.1 1 0 0 1 1 1 1 Nitronate monooxygenase DHO_dh PF01180.16 EWC43407.1 - 0.058 12.3 0.0 0.068 12.1 0.0 1.1 1 0 0 1 1 1 0 Dihydroorotate dehydrogenase vWF_A PF12450.3 EWC43409.1 - 0.02 14.6 0.0 0.039 13.6 0.0 1.4 1 0 0 1 1 1 0 von Willebrand factor PQ-loop PF04193.9 EWC43411.1 - 4.9e-19 67.6 1.4 9.6e-19 66.7 1.0 1.5 1 0 0 1 1 1 1 PQ loop repeat RHD3 PF05879.7 EWC43412.1 - 4.8e-235 781.9 0.0 7e-235 781.4 0.0 1.2 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) GBP PF02263.14 EWC43412.1 - 2.8e-08 33.1 0.0 5e-08 32.3 0.0 1.3 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain Dynamin_N PF00350.18 EWC43412.1 - 5.3e-06 26.3 0.0 1e-05 25.4 0.0 1.5 1 0 0 1 1 1 1 Dynamin family AAA_28 PF13521.1 EWC43412.1 - 6e-05 23.0 0.0 0.00014 21.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.18 EWC43412.1 - 0.00011 22.0 0.0 0.00035 20.4 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 EWC43412.1 - 0.0038 17.7 0.0 0.009 16.5 0.0 1.7 1 0 0 1 1 1 1 Miro-like protein Closter_coat PF01785.12 EWC43412.1 - 0.013 14.5 0.2 0.028 13.4 0.1 1.5 1 0 0 1 1 1 0 Closterovirus coat protein Septin PF00735.13 EWC43412.1 - 0.11 11.4 0.0 0.19 10.7 0.0 1.3 1 0 0 1 1 1 0 Septin MAD PF05557.8 EWC43413.1 - 0.00026 19.2 48.2 0.017 13.2 8.2 2.5 1 1 1 2 2 2 2 Mitotic checkpoint protein CENP-F_leu_zip PF10473.4 EWC43413.1 - 0.0027 17.5 54.0 0.0045 16.8 6.0 4.6 2 1 2 5 5 5 3 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DivIC PF04977.10 EWC43413.1 - 2.5 7.6 38.2 0.068 12.6 0.6 6.1 3 2 3 6 6 6 0 Septum formation initiator IncA PF04156.9 EWC43413.1 - 6.4 6.3 48.6 1.6 8.3 8.4 3.4 1 1 2 3 3 3 0 IncA protein ApbA_C PF08546.6 EWC43414.1 - 1.1e-22 80.3 0.0 1.7e-22 79.7 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal PAT1 PF09770.4 EWC43414.1 - 0.31 9.2 10.7 0.44 8.7 7.4 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 TMEM171 PF15471.1 EWC43414.1 - 0.66 8.7 4.8 1 8.0 3.3 1.2 1 0 0 1 1 1 0 Transmembrane protein family 171 AdoMet_MTase PF07757.8 EWC43415.1 - 1e-20 73.8 0.0 3.7e-20 72.1 0.0 2.0 2 1 0 2 2 2 1 Predicted AdoMet-dependent methyltransferase RRM_1 PF00076.17 EWC43415.1 - 9.4e-06 25.1 0.0 2.6e-05 23.7 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EWC43415.1 - 0.0067 16.3 0.0 0.015 15.2 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EWC43415.1 - 0.06 13.2 0.1 0.12 12.1 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Lyase_1 PF00206.15 EWC43416.1 - 2.2e-86 289.8 4.2 1.3e-74 251.1 0.0 2.2 1 1 1 2 2 2 2 Lyase FumaraseC_C PF10415.4 EWC43416.1 - 5.9e-21 74.2 0.0 1.2e-20 73.3 0.0 1.5 1 0 0 1 1 1 1 Fumarase C C-terminus RNase_PH PF01138.16 EWC43417.1 - 5.1e-10 39.7 0.0 1.1e-09 38.6 0.0 1.5 1 1 0 1 1 1 1 3' exoribonuclease family, domain 1 RRM_6 PF14259.1 EWC43418.1 - 1.4e-06 28.2 0.0 2.3e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 EWC43418.1 - 0.13 11.9 0.0 0.32 10.6 0.0 1.7 1 1 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pkinase PF00069.20 EWC43419.1 - 1.3e-70 237.5 0.0 1.6e-70 237.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC43419.1 - 2.9e-37 128.1 0.0 4.8e-37 127.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EWC43419.1 - 2.9e-05 23.1 0.0 0.00038 19.4 0.0 2.2 2 1 0 2 2 2 1 Kinase-like APH PF01636.18 EWC43419.1 - 7.9e-05 22.5 0.3 0.017 14.8 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.9 EWC43419.1 - 0.0031 16.6 0.1 0.0049 15.9 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.4 EWC43419.1 - 0.032 13.5 0.0 0.067 12.5 0.0 1.4 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Choline_kinase PF01633.15 EWC43419.1 - 0.057 12.9 0.1 0.11 12.0 0.0 1.4 1 1 0 1 1 1 0 Choline/ethanolamine kinase Zn_clus PF00172.13 EWC43420.1 - 1e-07 31.7 6.2 1.5e-07 31.1 4.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fic PF02661.13 EWC43422.1 - 8.6e-06 26.3 0.0 0.0019 18.8 0.0 2.9 1 1 0 1 1 1 1 Fic/DOC family Asp PF00026.18 EWC43423.1 - 3.2e-29 102.1 0.0 4.3e-29 101.7 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease SKG6 PF08693.5 EWC43423.1 - 0.00034 19.8 0.2 0.00063 19.0 0.2 1.5 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Syndecan PF01034.15 EWC43423.1 - 0.17 11.5 0.5 0.34 10.5 0.3 1.4 1 0 0 1 1 1 0 Syndecan domain RRM_1 PF00076.17 EWC43424.1 - 5.6e-41 138.0 1.2 2.7e-19 68.5 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EWC43424.1 - 4.4e-28 97.0 0.2 1.8e-14 53.4 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RBM39linker PF15519.1 EWC43424.1 - 3.6e-23 81.6 0.0 7.6e-23 80.5 0.0 1.6 1 0 0 1 1 1 1 linker between RRM2 and RRM3 domains in RBM39 protein RRM_5 PF13893.1 EWC43424.1 - 3.6e-18 65.1 0.0 6.7e-06 25.8 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MIP-T3 PF10243.4 EWC43424.1 - 0.23 9.8 28.9 0.37 9.2 20.1 1.3 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 CAF-1_p150 PF11600.3 EWC43424.1 - 4 6.7 31.2 8.9 5.6 21.6 1.5 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal ABC_membrane PF00664.18 EWC43425.1 - 1.8e-81 273.5 35.8 4.2e-43 147.7 12.8 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 EWC43425.1 - 1.3e-64 216.5 0.0 9.1e-32 110.2 0.0 2.7 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 EWC43425.1 - 5.9e-12 46.1 0.1 0.035 14.0 0.0 4.2 4 0 0 4 4 4 3 AAA domain SMC_N PF02463.14 EWC43425.1 - 3.4e-10 39.5 2.8 0.00063 19.0 0.0 4.4 3 1 0 4 4 4 2 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.4 EWC43425.1 - 4.1e-10 38.8 2.3 0.00016 20.4 0.1 2.7 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA_29 PF13555.1 EWC43425.1 - 3e-08 33.0 1.0 0.0011 18.4 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.1 EWC43425.1 - 3.4e-08 33.7 6.5 4.5e-05 23.5 0.0 3.5 2 1 0 2 2 2 2 AAA ATPase domain DUF258 PF03193.11 EWC43425.1 - 6.3e-06 25.4 0.0 0.072 12.2 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_17 PF13207.1 EWC43425.1 - 1.7e-05 25.6 0.0 0.035 14.9 0.0 2.8 2 0 0 2 2 2 1 AAA domain SbcCD_C PF13558.1 EWC43425.1 - 0.00011 22.0 2.2 0.21 11.5 0.2 3.9 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_25 PF13481.1 EWC43425.1 - 0.00012 21.5 0.3 0.6 9.4 0.0 3.0 3 0 0 3 3 3 2 AAA domain AAA_22 PF13401.1 EWC43425.1 - 0.00028 21.0 8.8 0.33 11.0 0.1 4.5 3 2 0 3 3 2 2 AAA domain AAA_33 PF13671.1 EWC43425.1 - 0.00087 19.1 0.0 2.5 7.9 0.0 3.0 2 0 0 2 2 2 2 AAA domain AAA_28 PF13521.1 EWC43425.1 - 0.0011 18.9 0.1 0.31 10.9 0.0 2.9 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.1 EWC43425.1 - 0.0025 18.1 0.0 0.63 10.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.7 EWC43425.1 - 0.0055 15.8 0.0 0.36 9.9 0.0 2.5 2 0 0 2 2 2 1 Zeta toxin AAA_10 PF12846.2 EWC43425.1 - 0.015 14.7 0.5 5.4 6.3 0.0 3.6 4 0 0 4 4 4 0 AAA-like domain AAA_23 PF13476.1 EWC43425.1 - 0.028 14.7 0.1 11 6.2 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.9 EWC43425.1 - 0.032 13.9 3.1 3 7.5 0.0 3.9 5 0 0 5 5 5 0 AAA domain (dynein-related subfamily) DUF87 PF01935.12 EWC43425.1 - 0.035 13.9 2.6 3.8 7.2 0.1 3.0 3 0 0 3 3 3 0 Domain of unknown function DUF87 G-alpha PF00503.15 EWC43425.1 - 0.043 12.5 0.0 0.97 8.0 0.0 2.3 2 0 0 2 2 2 0 G-protein alpha subunit RNA_helicase PF00910.17 EWC43425.1 - 0.079 13.1 0.1 7.5 6.7 0.0 3.1 2 0 0 2 2 2 0 RNA helicase AAA_15 PF13175.1 EWC43425.1 - 0.083 11.9 0.0 0.24 10.4 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain PRK PF00485.13 EWC43425.1 - 0.15 11.6 2.5 0.77 9.2 0.0 2.9 4 0 0 4 4 3 0 Phosphoribulokinase / Uridine kinase family AAA_14 PF13173.1 EWC43425.1 - 0.15 11.9 0.0 17 5.3 0.0 3.3 4 0 0 4 4 3 0 AAA domain MMR_HSR1 PF01926.18 EWC43425.1 - 0.16 11.9 0.1 6.4 6.7 0.0 2.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase Fungal_trans PF04082.13 EWC43426.1 - 1.3e-11 43.9 0.2 3.3e-11 42.5 0.1 1.7 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EWC43426.1 - 5.3e-10 39.0 13.0 1.1e-09 38.0 9.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ribosomal_S7 PF00177.16 EWC43427.1 - 4e-39 133.5 0.8 5.3e-39 133.1 0.6 1.1 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e PAP2 PF01569.16 EWC43428.1 - 3.7e-21 75.1 6.5 3.7e-21 75.1 4.5 1.8 2 0 0 2 2 2 1 PAP2 superfamily SPRY PF00622.23 EWC43430.1 - 2.2e-18 66.5 0.0 3.8e-18 65.7 0.0 1.4 1 0 0 1 1 1 1 SPRY domain DRTGG PF07085.7 EWC43431.1 - 0.061 12.9 0.1 2 8.0 0.0 2.4 2 0 0 2 2 2 0 DRTGG domain Cyt-b5 PF00173.23 EWC43432.1 - 1.6e-18 66.2 0.1 2.6e-17 62.3 0.0 2.7 3 0 0 3 3 3 1 Cytochrome b5-like Heme/Steroid binding domain FA_hydroxylase PF04116.8 EWC43432.1 - 1.4e-07 31.8 22.3 2e-07 31.3 14.6 1.8 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily ATP_synt_I PF03899.10 EWC43432.1 - 0.032 14.3 0.8 8.2 6.6 0.0 2.2 2 0 0 2 2 2 0 ATP synthase I chain F-box PF00646.28 EWC43433.1 - 1.2e-07 31.1 0.3 4.2e-05 23.0 0.0 2.8 2 0 0 2 2 2 2 F-box domain F-box-like PF12937.2 EWC43434.1 - 1e-07 31.5 0.0 2.4e-07 30.3 0.0 1.6 1 0 0 1 1 1 1 F-box-like CENP-I PF07778.6 EWC43435.1 - 0.064 11.4 0.5 0.087 11.0 0.4 1.1 1 0 0 1 1 1 0 Mis6 Rad51 PF08423.6 EWC43436.1 - 0.043 12.7 0.0 0.76 8.6 0.0 2.5 2 0 0 2 2 2 0 Rad51 Amidase PF01425.16 EWC43437.1 - 6.3e-75 252.7 0.0 8.4e-73 245.7 0.0 2.0 1 1 0 1 1 1 1 Amidase RTA1 PF04479.8 EWC43438.1 - 3.3e-28 98.7 6.2 4.6e-28 98.2 4.3 1.2 1 0 0 1 1 1 1 RTA1 like protein Methyltransf_31 PF13847.1 EWC43439.1 - 3.7e-15 55.8 0.0 5.1e-15 55.3 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EWC43439.1 - 2e-14 54.0 0.0 3e-14 53.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EWC43439.1 - 3.9e-06 27.2 0.0 7.8e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EWC43439.1 - 4.2e-06 26.7 0.0 7.3e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EWC43439.1 - 0.00073 19.8 0.0 0.0011 19.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EWC43439.1 - 0.00095 18.5 0.0 0.0015 17.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain MetW PF07021.7 EWC43439.1 - 0.0013 18.0 0.0 0.057 12.7 0.0 2.4 3 0 0 3 3 3 1 Methionine biosynthesis protein MetW Methyltransf_32 PF13679.1 EWC43439.1 - 0.0021 17.7 0.0 0.0023 17.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EWC43439.1 - 0.0021 17.7 0.0 0.0058 16.3 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EWC43439.1 - 0.0036 17.7 0.0 0.0087 16.5 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 EWC43439.1 - 0.084 11.9 0.0 0.28 10.2 0.0 1.7 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_16 PF10294.4 EWC43440.1 - 1.7e-10 40.5 0.0 2.4e-10 40.1 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_18 PF12847.2 EWC43440.1 - 0.056 14.0 0.0 0.12 12.9 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain GidB PF02527.10 EWC43440.1 - 0.076 12.1 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G NNMT_PNMT_TEMT PF01234.12 EWC43440.1 - 0.15 10.9 0.0 0.23 10.3 0.0 1.2 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family LMBR1 PF04791.11 EWC43441.1 - 5.2e-34 117.6 2.1 5.2e-34 117.6 1.4 1.4 2 0 0 2 2 2 1 LMBR1-like membrane protein SLS PF14611.1 EWC43442.1 - 8.9e-26 90.6 1.0 1.6e-25 89.7 0.2 1.9 2 0 0 2 2 2 1 Mitochondrial inner-membrane-bound regulator Secretin_N PF03958.12 EWC43442.1 - 0.0021 18.2 0.0 0.0086 16.2 0.0 2.0 1 0 0 1 1 1 1 Bacterial type II/III secretion system short domain DUF4440 PF14534.1 EWC43444.1 - 0.029 14.5 0.1 0.074 13.2 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) MAGE PF01454.14 EWC43445.1 - 5e-35 120.6 0.0 6.7e-35 120.2 0.0 1.2 1 0 0 1 1 1 1 MAGE family Daxx PF03344.10 EWC43445.1 - 0.45 8.9 14.7 0.67 8.3 10.2 1.3 1 0 0 1 1 1 0 Daxx Family RXT2_N PF08595.6 EWC43445.1 - 0.85 9.4 13.5 2.9 7.6 0.6 2.4 2 0 0 2 2 2 0 RXT2-like, N-terminal FAM176 PF14851.1 EWC43445.1 - 1.6 8.3 13.1 0.68 9.6 3.1 2.4 2 0 0 2 2 2 0 FAM176 family HEAT PF02985.17 EWC43446.1 - 6.5e-43 140.9 19.9 0.0023 17.8 0.0 13.6 14 0 0 14 14 14 11 HEAT repeat HEAT_2 PF13646.1 EWC43446.1 - 3.5e-31 107.3 11.1 1.8e-07 31.3 0.0 7.4 2 2 5 7 7 7 7 HEAT repeats Vac14_Fab1_bd PF12755.2 EWC43446.1 - 1.3e-11 44.7 2.3 0.071 13.5 0.0 7.5 5 2 4 9 9 9 3 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.1 EWC43446.1 - 7.7e-11 42.1 17.2 0.0032 17.9 0.3 9.2 7 3 4 11 11 11 3 HEAT-like repeat Adaptin_N PF01602.15 EWC43446.1 - 2.7e-07 29.3 10.3 0.02 13.2 0.3 5.4 3 1 2 5 5 5 3 Adaptin N terminal region DUF2435 PF10363.4 EWC43446.1 - 0.0002 21.1 2.8 0.13 12.1 0.1 4.1 3 0 0 3 3 3 1 Protein of unknown function (DUF2435) CLASP_N PF12348.3 EWC43446.1 - 0.00023 20.5 0.8 3.7 6.8 0.1 4.7 5 1 1 6 6 6 2 CLASP N terminal Arm PF00514.18 EWC43446.1 - 0.0011 18.6 10.9 0.17 11.7 0.0 6.4 8 0 0 8 8 7 1 Armadillo/beta-catenin-like repeat Cnd1 PF12717.2 EWC43446.1 - 0.062 13.1 4.7 2.2 8.1 0.0 4.3 3 1 1 4 4 4 0 non-SMC mitotic condensation complex subunit 1 Cnd3 PF12719.2 EWC43446.1 - 0.077 11.9 0.5 0.51 9.2 0.1 2.4 2 1 0 2 2 2 0 Nuclear condensing complex subunits, C-term domain Ecm29 PF13001.2 EWC43446.1 - 0.091 11.2 1.3 6.6 5.0 0.0 2.6 2 0 0 2 2 2 0 Proteasome stabiliser DNA_alkylation PF08713.6 EWC43446.1 - 0.096 12.1 0.1 1.3 8.5 0.0 2.7 2 1 0 3 3 3 0 DNA alkylation repair enzyme HEAT_PBS PF03130.11 EWC43446.1 - 0.32 11.5 3.3 2 9.1 0.1 4.1 5 0 0 5 5 3 0 PBS lyase HEAT-like repeat Proteasom_PSMB PF10508.4 EWC43446.1 - 1.1 7.4 4.6 1 7.5 0.1 2.6 2 1 1 3 3 3 0 Proteasome non-ATPase 26S subunit B3_4 PF03483.12 EWC43447.1 - 4.1e-23 81.7 0.0 6.5e-23 81.0 0.0 1.3 1 0 0 1 1 1 1 B3/4 domain B5 PF03484.10 EWC43447.1 - 4.6e-18 64.8 0.0 1.1e-15 57.2 0.0 2.5 2 0 0 2 2 2 2 tRNA synthetase B5 domain Herpes_V23 PF01802.12 EWC43447.1 - 0.052 12.5 0.0 0.083 11.9 0.0 1.3 1 0 0 1 1 1 0 Herpesvirus VP23 like capsid protein 2OG-FeII_Oxy_2 PF13532.1 EWC43448.1 - 2.6e-11 43.7 0.0 5.9e-10 39.2 0.0 2.1 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 EWC43448.1 - 8.2e-05 22.8 0.0 0.00023 21.4 0.0 1.7 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily UAA PF08449.6 EWC43449.1 - 1.7e-77 260.3 3.6 2.1e-77 260.0 2.5 1.0 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.15 EWC43449.1 - 7.2e-10 38.9 20.9 1.6e-07 31.4 2.0 3.2 3 0 0 3 3 3 2 EamA-like transporter family EmrE PF13536.1 EWC43449.1 - 6.2e-07 29.6 16.7 0.00023 21.3 2.3 3.4 3 1 0 3 3 3 2 Multidrug resistance efflux transporter Nuc_sug_transp PF04142.10 EWC43449.1 - 2.5e-06 26.7 0.9 0.0011 18.0 0.1 2.2 2 0 0 2 2 2 2 Nucleotide-sugar transporter TPT PF03151.11 EWC43449.1 - 4.9e-05 23.0 5.5 4.9e-05 23.0 3.8 2.7 2 1 0 2 2 2 1 Triose-phosphate Transporter family DUF914 PF06027.7 EWC43449.1 - 0.084 11.7 5.2 0.37 9.5 3.6 2.0 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF914) Abhydrolase_6 PF12697.2 EWC43450.1 - 3.1e-21 76.3 1.3 7.4e-21 75.0 0.9 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EWC43450.1 - 2.7e-08 33.6 0.0 5.5e-08 32.6 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EWC43450.1 - 0.0017 17.9 0.0 0.0026 17.3 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Herpes_UL17 PF04559.7 EWC43450.1 - 0.049 12.2 0.0 0.07 11.7 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus UL17 protein MFS_1 PF07690.11 EWC43451.1 - 2.1e-44 151.6 30.4 4.2e-35 121.0 15.8 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_3 PF05977.8 EWC43451.1 - 4.4e-05 21.7 14.3 0.00059 18.0 2.7 2.8 3 0 0 3 3 3 2 Transmembrane secretion effector DUF4306 PF14154.1 EWC43451.1 - 0.011 15.7 0.3 0.089 12.7 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4306) Sugar_tr PF00083.19 EWC43451.1 - 0.022 13.3 27.0 0.051 12.1 1.0 3.3 2 2 1 3 3 3 0 Sugar (and other) transporter ATG22 PF11700.3 EWC43451.1 - 0.037 12.5 23.6 0.75 8.1 0.7 3.7 2 2 1 3 3 3 0 Vacuole effluxer Atg22 like EMP70 PF02990.11 EWC43451.1 - 0.091 11.2 0.0 0.15 10.4 0.0 1.3 1 0 0 1 1 1 0 Endomembrane protein 70 MFS_1_like PF12832.2 EWC43451.1 - 0.21 11.3 3.7 6.1 6.7 0.0 3.6 4 0 0 4 4 4 0 MFS_1 like family V-ATPase_G PF03179.10 EWC43452.1 - 1.9e-30 105.2 17.5 2.2e-30 105.0 12.1 1.0 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit YusW PF14039.1 EWC43452.1 - 0.012 15.8 3.6 0.02 15.1 2.5 1.4 1 0 0 1 1 1 0 YusW-like protein ATP-synt_B PF00430.13 EWC43452.1 - 0.02 14.6 21.1 0.12 12.1 7.3 2.0 1 1 0 1 1 1 0 ATP synthase B/B' CF(0) RGS-like PF09128.6 EWC43452.1 - 0.09 12.2 3.3 0.093 12.2 2.3 1.1 1 0 0 1 1 1 0 Regulator of G protein signalling-like domain DUF607 PF04678.8 EWC43452.1 - 0.13 12.1 3.5 0.15 11.9 2.4 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF607 Nop25 PF09805.4 EWC43452.1 - 0.22 11.6 13.2 0.27 11.2 9.1 1.2 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) CAF-1_p150 PF11600.3 EWC43452.1 - 0.99 8.7 15.7 1.2 8.4 10.9 1.1 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal DUF2870 PF11069.3 EWC43452.1 - 1.5 8.8 5.7 2.2 8.3 3.7 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2870) Vfa1 PF08432.5 EWC43452.1 - 1.6 8.7 8.8 1.9 8.4 6.1 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 OmpH PF03938.9 EWC43452.1 - 2.6 7.9 16.2 4.1 7.3 11.2 1.4 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) Seryl_tRNA_N PF02403.17 EWC43452.1 - 2.9 7.9 12.2 1.5 8.8 6.8 1.8 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain KfrA_N PF11740.3 EWC43452.1 - 3.7 8.0 14.2 0.33 11.4 5.9 1.9 1 1 1 2 2 2 0 Plasmid replication region DNA-binding N-term Atg14 PF10186.4 EWC43452.1 - 4.8 6.0 9.1 5.2 5.9 6.3 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Methyltransf_16 PF10294.4 EWC43455.1 - 3e-19 69.1 0.0 4.4e-19 68.5 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase PrmA PF06325.8 EWC43455.1 - 5.2e-05 22.5 0.1 6.9e-05 22.1 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.2 EWC43455.1 - 0.0029 18.1 0.1 0.0052 17.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EWC43455.1 - 0.006 16.5 0.0 0.012 15.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.15 EWC43455.1 - 0.013 14.5 0.0 0.019 14.0 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Methyltransf_23 PF13489.1 EWC43455.1 - 0.055 13.1 0.0 0.12 12.1 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain Ribosomal_S24e PF01282.14 EWC43456.1 - 7.2e-34 115.4 0.0 1.2e-33 114.7 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S24e DnaJ PF00226.26 EWC43457.1 - 1.9e-16 59.5 0.1 3.2e-16 58.7 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain Yip1 PF04893.12 EWC43457.1 - 4.1 6.8 8.3 0.24 10.9 0.3 2.2 2 0 0 2 2 2 0 Yip1 domain Nsp1_C PF05064.8 EWC43458.1 - 6.7e-33 112.8 2.5 8.5e-33 112.4 0.2 2.0 2 0 0 2 2 2 1 Nsp1-like C-terminal region Nucleoporin_FG PF13634.1 EWC43458.1 - 2.3e-06 27.8 87.4 0.0038 17.4 7.0 3.6 2 1 1 3 3 3 3 Nucleoporin FG repeat region PRCC PF10253.4 EWC43458.1 - 0.0093 16.6 0.9 0.0093 16.6 0.6 1.9 2 0 0 2 2 2 1 Mitotic checkpoint regulator, MAD2B-interacting Muted PF14942.1 EWC43458.1 - 0.38 10.6 1.4 0.79 9.5 0.1 1.9 1 1 1 2 2 2 0 Organelle biogenesis, Muted-like protein Desmo_N PF06771.6 EWC43458.1 - 0.55 10.1 2.7 1.3 9.0 1.6 1.8 1 1 0 1 1 1 0 Viral Desmoplakin N-terminus SBDS PF01172.13 EWC43459.1 - 1.2e-23 82.6 0.2 1.4e-23 82.4 0.2 1.0 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein PhageP22-tail PF09251.5 EWC43459.1 - 0.015 13.6 0.0 0.016 13.5 0.0 1.0 1 0 0 1 1 1 0 Salmonella phage P22 tail-spike BNIP3 PF06553.7 EWC43459.1 - 0.056 12.8 1.1 0.073 12.4 0.8 1.2 1 0 0 1 1 1 0 BNIP3 Tropomyosin_1 PF12718.2 EWC43461.1 - 0.00053 19.8 21.0 0.00053 19.8 14.6 2.0 1 1 1 2 2 2 1 Tropomyosin like ADIP PF11559.3 EWC43461.1 - 0.019 14.8 23.9 0.26 11.2 4.4 2.6 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Tropomyosin PF00261.15 EWC43461.1 - 0.023 13.7 27.4 0.069 12.2 4.8 2.9 1 1 2 3 3 3 0 Tropomyosin IncA PF04156.9 EWC43461.1 - 0.078 12.5 34.5 0.34 10.4 11.6 2.8 2 1 1 3 3 3 0 IncA protein Shugoshin_N PF07558.6 EWC43461.1 - 0.13 11.9 3.3 1.2 8.8 0.1 2.6 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region Occludin_ELL PF07303.8 EWC43461.1 - 3.7 8.3 13.6 0.079 13.7 1.5 3.3 2 1 2 4 4 4 0 Occludin homology domain CHD5 PF04420.9 EWC43461.1 - 4.8 6.8 7.9 0.13 11.9 0.5 2.1 3 0 0 3 3 3 0 CHD5-like protein ubiquitin PF00240.18 EWC43462.1 - 1e-18 66.4 0.0 1.6e-18 65.8 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 EWC43462.1 - 3.2e-09 36.3 0.0 4.8e-09 35.7 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBA PF00627.26 EWC43462.1 - 8.9e-08 31.7 0.0 8.9e-08 31.7 0.0 2.9 3 0 0 3 3 3 1 UBA/TS-N domain DUF2407 PF10302.4 EWC43462.1 - 0.00026 21.1 0.0 0.00045 20.3 0.0 1.3 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.1 EWC43462.1 - 0.00049 19.9 0.0 0.0011 18.7 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 EWC43462.1 - 0.0015 18.7 0.0 0.0039 17.4 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin-like domain DUF1144 PF06610.8 EWC43463.1 - 0.064 13.0 0.6 0.09 12.5 0.0 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1144) NAD_binding_6 PF08030.7 EWC43464.1 - 2e-23 83.0 0.0 3.3e-23 82.2 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.7 EWC43464.1 - 2.6e-23 81.8 0.1 7.1e-23 80.4 0.0 1.8 2 0 0 2 2 2 1 FAD-binding domain Ferric_reduct PF01794.14 EWC43464.1 - 1.1e-17 64.2 7.7 1.1e-17 64.2 5.3 2.3 3 0 0 3 3 3 1 Ferric reductase like transmembrane component FAD_binding_6 PF00970.19 EWC43464.1 - 0.00015 21.8 0.0 0.00035 20.6 0.0 1.6 1 1 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.16 EWC43464.1 - 0.12 12.9 0.0 1.7 9.2 0.0 2.2 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain NADH_B2 PF14813.1 EWC43464.1 - 3.2 7.4 6.5 0.86 9.3 0.8 2.6 2 0 0 2 2 2 0 NADH dehydrogenase 1 beta subcomplex subunit 2 SNF2_N PF00176.18 EWC43465.1 - 7.2e-69 231.8 0.1 1e-68 231.3 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 EWC43465.1 - 1.1e-12 47.6 0.0 2.7e-12 46.3 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-C3HC4_3 PF13920.1 EWC43465.1 - 2.9e-07 30.0 5.0 5.5e-07 29.1 3.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EWC43465.1 - 5.7e-07 29.0 5.9 1.1e-06 28.1 4.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 EWC43465.1 - 9.7e-07 28.7 5.0 1.8e-06 27.8 3.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EWC43465.1 - 2.2e-05 24.1 3.9 4.2e-05 23.2 2.7 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.1 EWC43465.1 - 3e-05 23.6 2.3 6.9e-05 22.4 1.6 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.1 EWC43465.1 - 9.8e-05 21.9 4.5 0.00018 21.1 3.1 1.5 1 0 0 1 1 1 1 zinc-RING finger domain DEAD PF00270.24 EWC43465.1 - 0.0016 17.9 0.0 0.0037 16.7 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase zf-C3HC4_4 PF15227.1 EWC43465.1 - 0.039 13.8 5.2 0.094 12.6 3.6 1.7 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.1 EWC43465.1 - 0.058 12.9 4.7 0.19 11.3 3.3 1.8 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain SH3_1 PF00018.23 EWC43466.1 - 9.4e-12 44.1 0.0 1.8e-11 43.2 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 EWC43466.1 - 1.1e-11 44.1 0.1 1.9e-11 43.3 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SAM_2 PF07647.12 EWC43466.1 - 2.9e-10 39.8 0.2 5e-10 39.0 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PH PF00169.24 EWC43466.1 - 1.9e-07 31.2 0.0 4.2e-07 30.1 0.0 1.6 1 0 0 1 1 1 1 PH domain PH_11 PF15413.1 EWC43466.1 - 5e-06 26.7 0.0 1.4e-05 25.2 0.0 1.9 1 0 0 1 1 1 1 Pleckstrin homology domain SH3_2 PF07653.12 EWC43466.1 - 3.2e-05 23.3 0.0 6.7e-05 22.3 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SAM_1 PF00536.25 EWC43466.1 - 0.02 15.0 0.1 0.034 14.3 0.1 1.4 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Avl9 PF09794.4 EWC43467.1 - 1.1e-132 442.0 0.0 1.6e-132 441.5 0.0 1.2 1 0 0 1 1 1 1 Transport protein Avl9 SPA PF08616.5 EWC43467.1 - 8.7e-06 25.4 0.0 0.0026 17.4 0.0 2.3 2 0 0 2 2 2 2 Stabilization of polarity axis DUF2347 PF09804.4 EWC43467.1 - 0.0062 15.8 2.2 0.0062 15.8 1.5 4.2 4 1 0 4 4 4 2 Uncharacterized conserved protein (DUF2347) VIT1 PF01988.14 EWC43467.1 - 1.4 8.3 3.8 11 5.4 0.1 2.3 2 0 0 2 2 2 0 VIT family DUF4355 PF14265.1 EWC43467.1 - 7 6.6 31.0 7.9 6.4 5.8 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4355) DUF1510 PF07423.6 EWC43467.1 - 8.9 5.6 22.4 1 8.6 10.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1510) Pkinase PF00069.20 EWC43468.1 - 3.1e-73 246.1 0.0 3.7e-73 245.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC43468.1 - 1.6e-31 109.3 0.0 2e-31 108.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 EWC43468.1 - 6.4e-05 22.1 0.0 0.00022 20.3 0.0 1.7 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 EWC43468.1 - 0.00014 20.9 0.0 0.048 12.6 0.0 2.2 1 1 0 2 2 2 2 Kinase-like APH PF01636.18 EWC43468.1 - 0.00052 19.8 0.0 0.001 18.8 0.0 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.17 EWC43468.1 - 0.034 13.4 0.0 0.08 12.2 0.0 1.6 2 0 0 2 2 2 0 RIO1 family CAP PF00188.21 EWC43469.1 - 2.5e-07 31.1 0.1 2.5e-07 31.1 0.1 2.2 2 0 0 2 2 2 1 Cysteine-rich secretory protein family SKN1 PF03935.10 EWC43470.1 - 4.1e-232 770.7 0.4 4.8e-232 770.5 0.3 1.0 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) MARVEL PF01284.18 EWC43471.1 - 0.00092 19.0 6.4 0.0014 18.5 4.4 1.3 1 0 0 1 1 1 1 Membrane-associating domain Cullin PF00888.17 EWC43472.1 - 1.8e-204 680.6 15.4 2.2e-204 680.3 10.6 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.4 EWC43472.1 - 1.5e-25 88.8 5.6 1.7e-25 88.6 2.4 2.2 2 0 0 2 2 2 1 Cullin protein neddylation domain Abi_C PF14355.1 EWC43472.1 - 0.0072 16.2 0.0 0.024 14.5 0.0 1.9 1 0 0 1 1 1 1 Abortive infection C-terminus Iso_dh PF00180.15 EWC43473.1 - 5.6e-94 314.9 0.0 7e-94 314.6 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase PhzC-PhzF PF02567.11 EWC43474.1 - 1.5e-42 145.7 0.0 2.6e-42 144.9 0.0 1.4 1 1 0 1 1 1 1 Phenazine biosynthesis-like protein Pro_racemase PF05544.6 EWC43474.1 - 0.0062 15.4 0.0 0.011 14.6 0.0 1.3 1 0 0 1 1 1 1 Proline racemase Leu_zip PF15294.1 EWC43475.1 - 0.01 14.9 0.1 0.015 14.4 0.0 1.2 1 0 0 1 1 1 0 Leucine zipper DUF2046 PF09755.4 EWC43475.1 - 0.066 12.1 0.2 0.13 11.1 0.0 1.5 2 0 0 2 2 2 0 Uncharacterized conserved protein H4 (DUF2046) PAT1 PF09770.4 EWC43475.1 - 0.38 8.9 8.7 0.36 9.0 6.0 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Ank_2 PF12796.2 EWC43477.1 - 4.6e-10 39.7 0.0 6.6e-07 29.5 0.0 3.4 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 EWC43477.1 - 5.1e-09 36.0 0.0 0.018 15.2 0.0 3.9 3 0 0 3 3 3 3 Ankyrin repeats (many copies) NACHT PF05729.7 EWC43477.1 - 3.1e-06 26.9 0.0 1.5e-05 24.7 0.0 2.2 2 0 0 2 2 2 1 NACHT domain AAA_16 PF13191.1 EWC43477.1 - 4.4e-05 23.5 0.7 0.00017 21.6 0.0 2.4 3 0 0 3 3 3 1 AAA ATPase domain Ank PF00023.25 EWC43477.1 - 4.7e-05 22.9 0.2 8.1 6.4 0.0 5.0 5 0 0 5 5 5 2 Ankyrin repeat Ank_3 PF13606.1 EWC43477.1 - 5.5e-05 23.0 0.0 14 6.3 0.0 5.1 5 0 0 5 5 5 1 Ankyrin repeat AAA_22 PF13401.1 EWC43477.1 - 0.0027 17.8 0.0 0.0093 16.1 0.0 2.0 1 0 0 1 1 1 1 AAA domain KAP_NTPase PF07693.9 EWC43477.1 - 0.053 12.5 0.5 0.25 10.2 0.2 2.0 1 1 1 2 2 2 0 KAP family P-loop domain Astro_capsid PF03115.9 EWC43478.1 - 0.64 8.2 5.3 1 7.5 3.7 1.2 1 0 0 1 1 1 0 Astrovirus capsid protein precursor DUF848 PF05852.6 EWC43478.1 - 2.3 8.0 10.2 1.7 8.4 4.6 2.4 2 0 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) Sec5 PF15469.1 EWC43479.1 - 1.4e-49 168.3 0.1 3.1e-49 167.1 0.1 1.7 1 0 0 1 1 1 1 Exocyst complex component Sec5 Vps51 PF08700.6 EWC43479.1 - 9.8e-06 25.3 0.1 3e-05 23.7 0.1 1.9 1 0 0 1 1 1 1 Vps51/Vps67 Borrelia_lipo_1 PF05714.6 EWC43479.1 - 0.072 12.1 2.2 0.29 10.2 0.0 2.5 3 0 0 3 3 3 0 Borrelia burgdorferi virulent strain associated lipoprotein HAD_2 PF13419.1 EWC43480.1 - 6.8e-32 111.0 1.2 8.7e-32 110.7 0.8 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 EWC43480.1 - 8.2e-07 28.6 0.0 1.4e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like Acid_PPase PF12689.2 EWC43480.1 - 0.011 15.4 0.0 0.42 10.2 0.0 2.1 2 0 0 2 2 2 0 Acid Phosphatase Xpo1 PF08389.7 EWC43484.1 - 1.3e-30 106.2 0.1 1e-29 103.3 0.0 2.6 2 0 0 2 2 2 1 Exportin 1-like protein Exo_endo_phos PF03372.18 EWC43485.1 - 2e-22 80.3 0.0 3e-22 79.7 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family LRR_4 PF12799.2 EWC43485.1 - 9.2e-15 53.8 6.4 4.4e-07 29.3 0.3 2.6 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 EWC43485.1 - 3.1e-08 33.2 19.8 1e-05 25.1 2.4 2.2 1 1 2 3 3 3 3 Leucine rich repeat LRR_1 PF00560.28 EWC43485.1 - 1.1e-05 24.7 7.2 0.47 10.6 0.0 5.1 5 0 0 5 5 5 3 Leucine Rich Repeat LRR_7 PF13504.1 EWC43485.1 - 0.019 15.0 7.5 29 5.4 0.5 4.7 4 0 0 4 4 4 0 Leucine rich repeat Methyltransf_23 PF13489.1 EWC43486.1 - 5.1e-09 36.0 0.0 1e-08 35.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EWC43486.1 - 4.6e-08 33.4 0.0 1.1e-07 32.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EWC43486.1 - 7.8e-08 32.6 0.0 2.8e-07 30.8 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 EWC43486.1 - 2.5e-07 30.3 0.0 1.5e-05 24.6 0.0 2.8 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 EWC43486.1 - 9.9e-06 26.1 0.0 0.00018 22.0 0.0 2.5 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 EWC43486.1 - 9.2e-05 22.8 0.0 0.0011 19.4 0.0 2.5 2 1 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.13 EWC43486.1 - 0.00033 19.8 0.0 0.00076 18.6 0.0 1.6 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.12 EWC43486.1 - 0.026 13.5 0.0 0.27 10.2 0.0 2.1 2 0 0 2 2 2 0 Putative methyltransferase MetW PF07021.7 EWC43486.1 - 0.069 12.5 0.0 0.47 9.8 0.0 2.1 1 1 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_26 PF13659.1 EWC43486.1 - 0.1 12.6 0.0 0.19 11.7 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain Biotin_lipoyl PF00364.17 EWC43487.1 - 3.3e-18 65.0 0.2 9.3e-18 63.6 0.1 1.8 2 0 0 2 2 2 1 Biotin-requiring enzyme E3_binding PF02817.12 EWC43487.1 - 2.8e-09 36.4 0.1 1e-08 34.6 0.0 2.0 1 0 0 1 1 1 1 e3 binding domain Biotin_lipoyl_2 PF13533.1 EWC43487.1 - 7.6e-05 22.2 0.8 0.0052 16.4 0.0 2.8 2 1 1 3 3 3 1 Biotin-lipoyl like DNA_primase_lrg PF04104.9 EWC43488.1 - 1.2e-79 267.2 0.0 2.2e-79 266.4 0.0 1.4 2 0 0 2 2 2 1 Eukaryotic and archaeal DNA primase, large subunit DUF2457 PF10446.4 EWC43489.1 - 2.8e-71 240.6 28.9 2.8e-71 240.6 20.1 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF2457) DUF1510 PF07423.6 EWC43489.1 - 0.1 11.9 14.8 0.21 10.9 6.9 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1510) K_channel_TID PF07941.6 EWC43490.1 - 0.011 15.8 2.7 0.041 14.0 1.8 1.9 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain Peptidase_M18 PF02127.10 EWC43491.1 - 7.5e-165 548.6 0.0 5.9e-164 545.6 0.0 1.9 1 1 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.9 EWC43491.1 - 0.00051 18.8 0.1 0.0016 17.2 0.0 1.8 2 0 0 2 2 2 1 M42 glutamyl aminopeptidase WD40 PF00400.27 EWC43492.1 - 5.4e-40 133.8 2.4 4.2e-08 32.7 0.0 6.3 6 0 0 6 6 6 5 WD domain, G-beta repeat eIF2A PF08662.6 EWC43492.1 - 1.3e-09 38.0 0.3 0.0021 17.7 0.1 3.1 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A HLH PF00010.21 EWC43493.1 - 5.4e-15 54.8 0.1 1.2e-14 53.6 0.1 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain NTF2 PF02136.15 EWC43495.1 - 1.1e-26 93.5 0.2 1.6e-26 93.0 0.1 1.3 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain RRM_1 PF00076.17 EWC43495.1 - 1.7e-05 24.3 0.0 3e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EWC43495.1 - 8.1e-05 22.5 0.0 0.00016 21.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) eIF3_subunit PF08597.5 EWC43495.1 - 4.5 6.7 7.7 6.9 6.1 5.4 1.2 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Abhydrolase_6 PF12697.2 EWC43496.1 - 5e-06 26.5 0.0 5.2e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EWC43496.1 - 0.0091 15.5 0.0 0.0092 15.5 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Claudin_2 PF13903.1 EWC43497.1 - 0.75 9.4 7.0 7 6.3 4.7 2.0 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction DND1_DSRM PF14709.1 EWC43499.1 - 0.059 13.6 0.0 0.094 13.0 0.0 1.3 1 0 0 1 1 1 0 double strand RNA binding domain from DEAD END PROTEIN 1 TatD_DNase PF01026.16 EWC43500.1 - 3.4e-26 92.0 0.0 4.8e-26 91.4 0.0 1.2 1 0 0 1 1 1 1 TatD related DNase DUF202 PF02656.10 EWC43501.1 - 0.013 15.7 0.1 0.016 15.3 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF202) PgaD PF13994.1 EWC43501.1 - 0.073 12.5 0.0 0.084 12.3 0.0 1.1 1 0 0 1 1 1 0 PgaD-like protein Dscam_C PF12355.3 EWC43503.1 - 0.63 10.3 10.7 3.8 7.8 0.7 2.5 2 0 0 2 2 2 0 Down syndrome cell adhesion molecule C terminal Cellulase PF00150.13 EWC43504.1 - 7e-37 127.1 0.6 1e-36 126.6 0.4 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) SNF2_N PF00176.18 EWC43505.1 - 6.6e-67 225.4 0.2 4.8e-66 222.5 0.0 2.1 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.26 EWC43505.1 - 2.1e-17 62.7 0.0 7.8e-17 60.9 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Carn_acyltransf PF00755.15 EWC43506.1 - 9.5e-169 562.2 0.0 1.1e-168 562.0 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase Eaf7 PF07904.8 EWC43507.1 - 1.8e-23 82.3 0.1 1.8e-23 82.3 0.0 2.8 3 1 0 3 3 3 1 Chromatin modification-related protein EAF7 Hamartin PF04388.7 EWC43507.1 - 0.57 8.8 14.9 0.72 8.4 10.3 1.2 1 0 0 1 1 1 0 Hamartin protein Spc97_Spc98 PF04130.8 EWC43508.1 - 1.8e-60 204.8 0.0 2.6e-60 204.2 0.0 1.2 1 0 0 1 1 1 1 Spc97 / Spc98 family GFO_IDH_MocA PF01408.17 EWC43511.1 - 4.6e-25 88.4 0.0 8.3e-25 87.6 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.12 EWC43511.1 - 6.4e-05 22.7 0.0 0.00016 21.3 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain NAD_binding_3 PF03447.11 EWC43511.1 - 0.00027 21.3 0.1 0.00051 20.4 0.0 1.5 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain Semialdhyde_dh PF01118.19 EWC43511.1 - 0.00038 20.7 0.0 0.00073 19.8 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain AAA_33 PF13671.1 EWC43511.1 - 0.065 13.1 0.0 0.17 11.7 0.0 1.5 1 1 0 1 1 1 0 AAA domain MCM PF00493.18 EWC43512.1 - 1.2e-128 428.5 0.2 1.8e-128 427.9 0.2 1.3 1 0 0 1 1 1 1 MCM2/3/5 family MCM_N PF14551.1 EWC43512.1 - 6.7e-22 78.2 0.0 1.6e-21 77.0 0.0 1.7 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.16 EWC43512.1 - 1.4e-07 30.9 0.0 1.6e-06 27.4 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.6 EWC43512.1 - 0.0055 16.3 0.0 0.02 14.4 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 EWC43512.1 - 0.014 14.8 0.0 0.047 13.1 0.0 1.8 2 0 0 2 2 2 0 Sigma-54 interaction domain p450 PF00067.17 EWC43513.1 - 5.6e-52 176.8 0.0 7.9e-52 176.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Histone PF00125.19 EWC43514.1 - 8.7e-26 89.8 0.0 1.1e-25 89.5 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 EWC43514.1 - 1.3e-05 25.1 0.0 1.8e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 EWC43515.1 - 9.8e-22 76.8 0.2 1.4e-21 76.3 0.2 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 EWC43515.1 - 0.00011 22.2 0.0 0.00011 22.2 0.0 1.9 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.8 EWC43515.1 - 0.00022 21.4 0.0 0.00038 20.6 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A Mitofilin PF09731.4 EWC43515.1 - 0.005 15.5 1.5 0.0063 15.2 1.1 1.1 1 0 0 1 1 1 1 Mitochondrial inner membrane protein RP-C PF03428.8 EWC43515.1 - 0.0096 15.3 0.1 0.014 14.9 0.1 1.2 1 0 0 1 1 1 1 Replication protein C N-terminal domain DUF1018 PF06252.7 EWC43515.1 - 0.013 16.0 0.3 0.019 15.5 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1018) NCKAP5 PF15246.1 EWC43515.1 - 0.025 13.9 1.2 0.029 13.7 0.8 1.2 1 0 0 1 1 1 0 Nck-associated protein 5, Peripheral clock protein NUDIX PF00293.23 EWC43516.1 - 4.3e-12 45.8 0.0 9.4e-12 44.7 0.0 1.5 1 0 0 1 1 1 1 NUDIX domain DUF1910 PF08928.5 EWC43516.1 - 0.058 13.4 3.7 0.25 11.3 0.1 2.6 1 1 2 3 3 3 0 Domain of unknown function (DUF1910) eIF3_N PF09440.5 EWC43517.1 - 3.4e-43 146.9 1.7 8.4e-43 145.7 0.6 2.1 3 0 0 3 3 3 1 eIF3 subunit 6 N terminal domain PCI PF01399.22 EWC43517.1 - 1.2e-13 51.2 0.2 3.9e-13 49.6 0.0 2.0 2 0 0 2 2 2 1 PCI domain PCI_Csn8 PF10075.4 EWC43517.1 - 0.024 14.3 0.2 0.25 11.1 0.0 2.5 2 0 0 2 2 2 0 COP9 signalosome, subunit CSN8 DUF771 PF05595.6 EWC43517.1 - 0.054 13.4 0.2 0.42 10.5 0.1 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF771) Oxysterol_BP PF01237.13 EWC43518.1 - 6.9e-39 133.3 0.0 8.9e-28 96.7 0.0 2.1 1 1 1 2 2 2 2 Oxysterol-binding protein COX4 PF02936.9 EWC43519.1 - 1.3e-45 154.6 0.0 1.5e-45 154.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV DUF1104 PF06518.6 EWC43519.1 - 0.12 12.5 0.2 0.38 10.9 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1104) DUF3106 PF11304.3 EWC43519.1 - 0.44 10.9 4.0 0.32 11.4 0.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3106) Gp_dh_C PF02800.15 EWC43520.1 - 7.2e-74 246.4 0.0 9.8e-74 246.0 0.0 1.2 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.19 EWC43520.1 - 1.1e-57 194.2 0.0 1.7e-57 193.5 0.0 1.3 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.15 EWC43520.1 - 0.0023 17.8 0.2 0.045 13.6 0.0 2.5 3 0 0 3 3 3 1 Dihydrodipicolinate reductase, N-terminus SAE2 PF08573.5 EWC43521.1 - 4.2e-08 33.7 1.7 4.2e-08 33.7 1.1 2.3 2 0 0 2 2 2 1 DNA repair protein endonuclease SAE2/CtIP C-terminus Arm PF00514.18 EWC43522.1 - 0.00015 21.4 13.0 0.089 12.6 0.1 7.3 8 0 0 8 8 8 2 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.1 EWC43522.1 - 0.0071 16.8 5.9 1.1 9.8 0.1 5.9 5 1 0 5 5 5 1 HEAT-like repeat DUF2454 PF10521.4 EWC43522.1 - 0.021 13.8 0.8 0.05 12.6 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2454) HEAT PF02985.17 EWC43522.1 - 0.025 14.6 8.1 1.3 9.2 0.0 6.0 7 0 0 7 7 7 0 HEAT repeat Cyclin PF08613.6 EWC43523.1 - 1.9e-28 99.7 0.1 3.9e-28 98.7 0.1 1.7 1 1 0 1 1 1 1 Cyclin Cyclin_N PF00134.18 EWC43523.1 - 0.18 11.3 0.0 0.29 10.6 0.0 1.3 1 0 0 1 1 1 0 Cyclin, N-terminal domain Ndc1_Nup PF09531.5 EWC43523.1 - 0.89 7.8 3.7 1.2 7.4 2.6 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Mito_carr PF00153.22 EWC43524.1 - 4.4e-16 58.3 0.5 3.6e-10 39.3 0.0 3.1 3 1 0 3 3 3 2 Mitochondrial carrier protein ERG4_ERG24 PF01222.12 EWC43525.1 - 5.2e-137 456.8 21.1 6.9e-137 456.5 14.6 1.1 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family Fructosamin_kin PF03881.9 EWC43525.1 - 6.4e-64 215.7 0.0 9.2e-64 215.1 0.0 1.2 1 0 0 1 1 1 1 Fructosamine kinase APH PF01636.18 EWC43525.1 - 4.9e-06 26.4 0.0 8.5e-06 25.6 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Velvet PF11754.3 EWC43526.1 - 6.5e-63 212.0 0.0 1.3e-62 211.0 0.0 1.5 1 0 0 1 1 1 1 Velvet factor DUF4653 PF15546.1 EWC43527.1 - 0.15 11.3 4.6 0.45 9.7 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4653) SPT16 PF08644.6 EWC43528.1 - 7.1e-57 191.5 0.6 2.3e-56 189.8 0.4 2.0 1 0 0 1 1 1 1 FACT complex subunit (SPT16/CDC68) FACT-Spt16_Nlob PF14826.1 EWC43528.1 - 1e-44 151.9 0.1 1e-44 151.9 0.1 2.2 2 0 0 2 2 2 1 FACT complex subunit SPT16 N-terminal lobe domain Peptidase_M24 PF00557.19 EWC43528.1 - 7.8e-22 77.8 0.0 1.4e-21 77.0 0.0 1.4 1 0 0 1 1 1 1 Metallopeptidase family M24 Rtt106 PF08512.7 EWC43528.1 - 2.1e-20 72.5 0.0 6.2e-20 70.9 0.0 1.9 1 0 0 1 1 1 1 Histone chaperone Rttp106-like RTA1 PF04479.8 EWC43529.1 - 6.2e-20 71.6 1.3 1e-19 70.9 0.9 1.3 1 0 0 1 1 1 1 RTA1 like protein DUF1635 PF07795.6 EWC43529.1 - 0.85 8.9 3.9 1.5 8.1 0.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1635) DUF308 PF03729.8 EWC43529.1 - 3.9 7.5 7.7 0.32 11.0 0.3 2.9 3 0 0 3 3 3 0 Short repeat of unknown function (DUF308) 6PF2K PF01591.13 EWC43530.1 - 4.3e-64 215.6 0.0 2.9e-45 154.0 0.0 2.2 2 0 0 2 2 2 2 6-phosphofructo-2-kinase His_Phos_1 PF00300.17 EWC43530.1 - 1.2e-25 90.4 0.0 5.8e-25 88.2 0.0 2.0 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.1 EWC43530.1 - 6.9e-05 22.7 0.0 0.0016 18.3 0.0 2.4 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 EWC43530.1 - 0.00042 21.1 0.1 0.0028 18.4 0.0 2.3 3 0 0 3 3 3 1 AAA domain Thoc2 PF11732.3 EWC43530.1 - 0.0039 16.9 0.0 0.037 13.8 0.0 2.2 2 0 0 2 2 2 1 Transcription- and export-related complex subunit KTI12 PF08433.5 EWC43530.1 - 0.017 14.3 0.0 0.046 12.9 0.0 1.6 2 0 0 2 2 2 0 Chromatin associated protein KTI12 dCMP_cyt_deam_1 PF00383.17 EWC43531.1 - 1.3e-10 40.8 0.1 3.1e-10 39.6 0.0 1.6 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MFS_1 PF07690.11 EWC43532.1 - 1e-21 77.0 58.1 3.2e-18 65.5 23.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3376 PF11856.3 EWC43532.1 - 0.00084 18.8 8.2 0.0013 18.2 5.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3376) zf-RING_2 PF13639.1 EWC43534.1 - 7.6e-12 44.8 0.4 7.6e-12 44.8 0.3 1.6 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.1 EWC43534.1 - 3.3e-07 30.2 0.5 7.4e-07 29.0 0.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EWC43534.1 - 1.4e-05 24.6 0.3 1.4e-05 24.6 0.2 1.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 EWC43534.1 - 1.8e-05 24.3 0.2 3.8e-05 23.3 0.2 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.1 EWC43534.1 - 6e-05 22.6 0.2 6e-05 22.6 0.1 1.6 2 0 0 2 2 2 1 zinc-RING finger domain zf-rbx1 PF12678.2 EWC43534.1 - 0.00034 20.6 0.0 0.00076 19.5 0.0 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4_3 PF13920.1 EWC43534.1 - 0.0099 15.5 0.2 0.019 14.6 0.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 EWC43534.1 - 0.016 15.0 0.4 0.04 13.8 0.3 1.7 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING SP_C-Propep PF08999.5 EWC43534.1 - 0.12 11.8 0.0 0.26 10.7 0.0 1.5 1 0 0 1 1 1 0 Surfactant protein C, N terminal propeptide PPP4R2 PF09184.6 EWC43535.1 - 6.9e-15 55.3 0.0 8.4e-13 48.5 0.0 2.2 2 0 0 2 2 2 2 PPP4R2 NHL PF01436.16 EWC43536.1 - 5.5e-05 22.9 0.1 0.067 13.1 0.0 3.7 4 0 0 4 4 4 2 NHL repeat GSDH PF07995.6 EWC43536.1 - 6.6e-05 22.1 0.2 0.00056 19.0 0.1 2.5 1 1 0 1 1 1 1 Glucose / Sorbosone dehydrogenase SGL PF08450.7 EWC43536.1 - 0.0011 18.4 0.0 0.047 13.0 0.0 2.5 2 1 0 2 2 2 1 SMP-30/Gluconolaconase/LRE-like region Toxin_54 PF15533.1 EWC43536.1 - 0.019 15.1 0.0 1.9 8.8 0.0 2.8 3 0 0 3 3 3 0 Putative toxin 54 PSCyt2 PF07583.6 EWC43537.1 - 0.0064 16.0 0.1 0.009 15.5 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1549) zf-trcl PF13451.1 EWC43537.1 - 0.023 14.3 0.3 0.1 12.2 0.0 1.9 2 0 0 2 2 2 0 Probable zinc-binding domain Elf1 PF05129.8 EWC43537.1 - 0.044 13.4 2.8 0.081 12.6 1.6 1.7 1 1 0 1 1 1 0 Transcription elongation factor Elf1 like zf-DNL PF05180.7 EWC43537.1 - 0.094 12.4 1.2 3.2 7.5 0.1 2.3 2 0 0 2 2 2 0 DNL zinc finger RE_SinI PF09570.5 EWC43537.1 - 0.12 11.3 0.0 0.13 11.2 0.0 1.0 1 0 0 1 1 1 0 SinI restriction endonuclease zinc_ribbon_4 PF13717.1 EWC43537.1 - 0.16 11.7 1.8 12 5.6 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_5 PF13719.1 EWC43537.1 - 0.18 11.3 1.7 12 5.5 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain HMG14_17 PF01101.13 EWC43538.1 - 0.18 12.5 5.1 0.3 11.8 3.5 1.3 1 0 0 1 1 1 0 HMG14 and HMG17 2OG-FeII_Oxy PF03171.15 EWC43539.1 - 0.0011 19.1 0.0 0.0024 18.1 0.0 1.6 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Catalase PF00199.14 EWC43540.1 - 1.6e-160 533.9 0.0 2.3e-160 533.4 0.0 1.2 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.7 EWC43540.1 - 1.7e-16 59.8 0.0 3.5e-16 58.8 0.0 1.6 1 0 0 1 1 1 1 Catalase-related immune-responsive DJ-1_PfpI PF01965.19 EWC43540.1 - 1e-07 31.4 0.0 2.2e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 DJ-1/PfpI family FRG1 PF06229.7 EWC43541.1 - 7.4e-41 139.7 0.0 7.4e-41 139.7 0.0 1.9 2 0 0 2 2 2 1 FRG1-like family Fascin PF06268.8 EWC43541.1 - 0.0019 18.2 0.0 0.0054 16.8 0.0 1.8 1 0 0 1 1 1 1 Fascin domain DUF496 PF04363.7 EWC43541.1 - 0.027 14.2 0.3 0.027 14.2 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF496) Spc7 PF08317.6 EWC43541.1 - 0.36 9.4 8.3 0.78 8.3 5.8 1.5 1 0 0 1 1 1 0 Spc7 kinetochore protein UQ_con PF00179.21 EWC43542.1 - 1.1e-49 167.4 0.0 1.3e-49 167.2 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 EWC43542.1 - 0.0015 18.4 0.0 0.002 18.0 0.0 1.4 1 1 0 1 1 1 1 RWD domain UEV PF05743.8 EWC43542.1 - 0.0015 18.1 0.0 0.0021 17.7 0.0 1.3 1 0 0 1 1 1 1 UEV domain Prok-E2_B PF14461.1 EWC43542.1 - 0.018 14.8 0.0 0.024 14.3 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B Pkinase PF00069.20 EWC43543.1 - 2.2e-64 217.1 0.0 3.1e-64 216.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC43543.1 - 8.7e-31 106.9 0.0 1.2e-30 106.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EWC43543.1 - 2.7e-07 29.8 0.0 4e-07 29.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.6 EWC43543.1 - 0.027 13.3 0.0 0.047 12.5 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 APH PF01636.18 EWC43543.1 - 0.044 13.5 0.0 0.15 11.7 0.0 1.8 1 1 1 2 2 2 0 Phosphotransferase enzyme family INO80_Ies4 PF08193.6 EWC43547.1 - 6.8e-31 107.9 14.5 7.1e-31 107.8 9.7 1.3 1 1 0 1 1 1 1 INO80 complex subunit Ies4 Peptidase_S8 PF00082.17 EWC43548.1 - 2.6e-41 141.6 2.3 2.6e-41 141.6 1.6 1.5 2 0 0 2 2 2 1 Subtilase family Inhibitor_I9 PF05922.11 EWC43548.1 - 0.033 14.7 0.0 0.057 14.0 0.0 1.4 1 0 0 1 1 1 0 Peptidase inhibitor I9 Glyco_hydro_16 PF00722.16 EWC43549.1 - 6.7e-42 142.8 6.4 1.1e-41 142.1 4.4 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Conotoxin PF02950.12 EWC43549.1 - 0.22 12.3 2.1 0.47 11.2 1.5 1.5 1 0 0 1 1 1 0 Conotoxin Chitin_bind_1 PF00187.14 EWC43549.1 - 0.54 10.2 20.7 0.042 13.8 10.9 1.7 2 0 0 2 2 2 0 Chitin recognition protein AKAP7_NLS PF10469.4 EWC43550.1 - 1.4e-22 80.4 0.0 1.7e-22 80.1 0.0 1.1 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain Glyco_hydro_76 PF03663.9 EWC43551.1 - 2.2e-22 79.9 6.6 6.3e-21 75.1 4.6 2.6 1 1 0 1 1 1 1 Glycosyl hydrolase family 76 DUF498 PF04430.9 EWC43552.1 - 1.9e-24 85.3 0.0 2.5e-24 84.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF498/DUF598) PA26 PF04636.8 EWC43553.1 - 1.5e-69 234.8 0.0 6.1e-46 157.0 0.0 3.1 3 0 0 3 3 3 3 PA26 p53-induced protein (sestrin) NIF PF03031.13 EWC43554.1 - 2.5e-41 141.0 0.0 3.4e-41 140.5 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase COX5B PF01215.14 EWC43555.1 - 1.7e-35 121.6 0.0 2.3e-35 121.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Vb PROCN PF08083.6 EWC43556.1 - 1.6e-218 725.1 4.7 2.4e-218 724.5 3.2 1.3 1 0 0 1 1 1 1 PROCN (NUC071) domain PRP8_domainIV PF12134.3 EWC43556.1 - 8.1e-123 408.1 1.2 1.4e-122 407.4 0.8 1.4 1 0 0 1 1 1 1 PRP8 domain IV core U6-snRNA_bdg PF10596.4 EWC43556.1 - 7.9e-89 295.0 0.7 1.6e-88 294.1 0.5 1.5 1 0 0 1 1 1 1 U6-snRNA interacting domain of PrP8 PRO8NT PF08082.6 EWC43556.1 - 1.9e-76 254.9 2.6 3.9e-76 253.8 1.8 1.6 1 0 0 1 1 1 1 PRO8NT (NUC069), PrP8 N-terminal domain U5_2-snRNA_bdg PF10597.4 EWC43556.1 - 3.9e-66 220.7 0.1 7.5e-66 219.8 0.1 1.5 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 RRM_4 PF10598.4 EWC43556.1 - 5.3e-44 148.0 0.1 1.3e-43 146.7 0.1 1.7 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 PROCT PF08084.6 EWC43556.1 - 3.7e-39 133.2 0.0 1.3e-38 131.5 0.0 2.0 2 0 0 2 2 2 1 PROCT (NUC072) domain JAB PF01398.16 EWC43556.1 - 4.6e-05 23.1 0.2 0.00012 21.8 0.1 1.7 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Ribosomal_L34e PF01199.13 EWC43557.1 - 1.3e-36 124.7 4.5 1.7e-36 124.3 3.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L34e DUF1428 PF07237.6 EWC43557.1 - 0.092 12.6 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1428) XLF PF09302.6 EWC43558.1 - 5e-25 88.2 0.0 9.8e-25 87.2 0.0 1.5 1 0 0 1 1 1 1 XLF (XRCC4-like factor) Fork_head PF00250.13 EWC43559.1 - 2.3e-23 82.0 0.1 1.5e-22 79.3 0.0 2.2 2 0 0 2 2 2 1 Fork head domain Cactin_mid PF10312.4 EWC43560.1 - 6e-64 214.8 6.7 6e-64 214.8 4.6 1.6 2 0 0 2 2 2 1 Conserved mid region of cactin CactinC_cactus PF09732.4 EWC43560.1 - 6.6e-55 184.0 3.6 1.1e-54 183.3 2.5 1.4 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein SAYSvFN PF10260.4 EWC43561.1 - 1.1e-20 73.0 0.2 1.5e-20 72.6 0.1 1.2 1 0 0 1 1 1 1 Uncharacterized conserved domain (SAYSvFN) ADH_zinc_N PF00107.21 EWC43564.1 - 1.3e-22 79.7 0.3 2e-22 79.1 0.2 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 EWC43564.1 - 7.3e-11 41.7 0.0 1.5e-09 37.5 0.0 2.6 2 1 1 3 3 3 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.1 EWC43564.1 - 1.3e-09 39.0 0.0 2.7e-09 37.9 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Senescence PF06911.7 EWC43565.1 - 6.6e-11 42.2 8.8 8.9e-11 41.8 6.1 1.1 1 0 0 1 1 1 1 Senescence-associated protein FG-GAP_2 PF14312.1 EWC43565.1 - 0.037 14.0 2.0 0.12 12.4 1.4 1.9 1 0 0 1 1 1 0 FG-GAP repeat Ribosomal_S19e PF01090.14 EWC43566.1 - 1.3e-57 193.1 0.2 1.5e-57 192.9 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e DUF805 PF05656.9 EWC43568.1 - 0.00037 20.2 1.7 0.00037 20.2 1.2 2.8 1 1 2 3 3 3 1 Protein of unknown function (DUF805) zf-C2H2_4 PF13894.1 EWC43569.1 - 0.021 15.1 3.5 0.15 12.4 0.0 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.21 EWC43569.1 - 0.04 14.2 4.5 0.15 12.4 0.1 2.6 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-Di19 PF05605.7 EWC43569.1 - 0.8 9.8 4.0 12 6.0 0.2 2.3 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Abhydrolase_6 PF12697.2 EWC43570.1 - 6e-27 95.0 0.0 9.1e-27 94.4 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EWC43570.1 - 7.8e-18 64.6 0.0 1.5e-17 63.7 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family DSPc PF00782.15 EWC43570.1 - 2.7e-11 43.1 0.0 5.8e-11 42.0 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Abhydrolase_1 PF00561.15 EWC43570.1 - 6e-11 42.3 0.0 1.5e-09 37.7 0.0 2.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Y_phosphatase PF00102.22 EWC43570.1 - 0.00088 18.6 0.0 0.0018 17.6 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Abhydrolase_2 PF02230.11 EWC43570.1 - 0.0011 18.5 0.4 4.9 6.5 0.0 3.2 3 0 0 3 3 3 1 Phospholipase/Carboxylesterase BAAT_C PF08840.6 EWC43570.1 - 0.0011 18.7 0.2 0.0025 17.5 0.0 1.6 2 0 0 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal Hydrolase_4 PF12146.3 EWC43570.1 - 0.0042 16.9 0.2 0.016 15.0 0.0 2.0 2 0 0 2 2 2 1 Putative lysophospholipase Peptidase_S9 PF00326.16 EWC43570.1 - 0.0066 15.6 0.0 0.018 14.2 0.0 1.6 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_4 PF08386.5 EWC43570.1 - 0.0072 16.1 0.0 0.015 15.1 0.0 1.4 1 0 0 1 1 1 1 TAP-like protein PTPlike_phytase PF14566.1 EWC43570.1 - 0.017 15.1 0.0 0.037 14.0 0.0 1.5 1 1 0 1 1 1 0 Inositol hexakisphosphate PGAP1 PF07819.8 EWC43570.1 - 0.046 13.3 0.3 0.22 11.0 0.2 2.0 1 1 0 1 1 1 0 PGAP1-like protein Lipase_3 PF01764.20 EWC43570.1 - 0.065 12.8 0.0 0.14 11.7 0.0 1.6 1 0 0 1 1 1 0 Lipase (class 3) ILVD_EDD PF00920.16 EWC43571.1 - 4.2e-198 659.0 0.1 4.8e-198 658.8 0.0 1.0 1 0 0 1 1 1 1 Dehydratase family Inhibitor_I78 PF11720.3 EWC43571.1 - 0.07 12.8 0.0 0.21 11.3 0.0 1.8 1 0 0 1 1 1 0 Peptidase inhibitor I78 family Glyco_hydro_61 PF03443.9 EWC43572.1 - 4.6e-56 190.0 0.1 4.6e-56 190.0 0.0 2.0 2 0 0 2 2 2 1 Glycosyl hydrolase family 61 CBM_1 PF00734.13 EWC43572.1 - 1e-13 50.6 8.0 3.2e-13 49.0 5.5 2.0 1 0 0 1 1 1 1 Fungal cellulose binding domain E1-E2_ATPase PF00122.15 EWC43573.1 - 4e-63 212.5 0.5 7.1e-63 211.7 0.3 1.4 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 EWC43573.1 - 2.2e-32 112.0 1.8 2.2e-32 112.0 1.2 2.0 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 EWC43573.1 - 5.8e-29 102.0 0.0 7.2e-28 98.4 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 EWC43573.1 - 3.9e-21 74.8 0.0 3.1e-20 71.9 0.0 2.3 2 0 0 2 2 2 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Cation_ATPase_N PF00690.21 EWC43573.1 - 9.7e-19 66.6 0.1 3.5e-18 64.8 0.0 2.1 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus HAD PF12710.2 EWC43573.1 - 9.2e-14 52.0 0.0 2e-13 50.9 0.0 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 EWC43573.1 - 0.00029 20.4 1.1 0.0027 17.3 0.4 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DctM PF06808.7 EWC43573.1 - 0.0012 17.5 2.0 0.0021 16.7 0.1 2.0 2 0 0 2 2 2 1 DctM-like transporters 2TM PF13239.1 EWC43573.1 - 1.1 9.3 0.0 1.1 9.3 0.0 3.7 4 0 0 4 4 4 0 2TM domain IMPDH PF00478.20 EWC43574.1 - 2.3e-133 444.4 2.8 2.8e-133 444.1 2.0 1.1 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.23 EWC43574.1 - 4.6e-15 55.1 0.3 1.2e-06 28.1 0.0 2.5 2 0 0 2 2 2 2 CBS domain FMN_dh PF01070.13 EWC43574.1 - 4.5e-07 29.0 1.7 4.7e-06 25.7 0.7 2.3 2 0 0 2 2 2 1 FMN-dependent dehydrogenase NMO PF03060.10 EWC43574.1 - 0.0018 17.5 7.6 0.14 11.3 3.1 2.5 3 0 0 3 3 3 2 Nitronate monooxygenase His_biosynth PF00977.16 EWC43574.1 - 0.0085 15.3 5.0 0.039 13.2 1.2 2.8 2 1 0 2 2 2 1 Histidine biosynthesis protein SH3BGR PF04908.10 EWC43575.1 - 5.1e-06 26.3 0.0 1e-05 25.3 0.0 1.6 1 0 0 1 1 1 1 SH3-binding, glutamic acid-rich protein GST_N_3 PF13417.1 EWC43575.1 - 0.00042 20.4 0.0 0.00073 19.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Glutaredoxin PF00462.19 EWC43575.1 - 0.0047 16.8 0.0 0.022 14.7 0.0 2.0 2 0 0 2 2 2 1 Glutaredoxin GST_N_3 PF13417.1 EWC43576.1 - 8.6e-12 45.1 0.0 1.6e-11 44.2 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 EWC43576.1 - 9.4e-12 44.7 0.0 2e-11 43.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.20 EWC43576.1 - 4.5e-11 42.5 0.0 6.5e-11 42.0 0.0 1.4 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.15 EWC43576.1 - 3.8e-10 39.7 0.0 7.4e-10 38.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 EWC43576.1 - 3.4e-09 36.4 0.0 5.8e-09 35.7 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 EWC43576.1 - 8.2e-06 26.2 0.1 1.3e-05 25.6 0.1 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain NpwBP PF12622.2 EWC43576.1 - 0.019 15.4 0.4 3.1 8.3 0.2 2.6 3 0 0 3 3 3 0 mRNA biogenesis factor FAP PF07174.6 EWC43576.1 - 0.14 11.4 0.7 0.18 11.0 0.5 1.1 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) Mito_fiss_reg PF05308.6 EWC43578.1 - 0.023 14.0 4.4 0.03 13.6 3.1 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator HrpJ PF07201.6 EWC43579.1 - 0.92 9.5 9.9 1.7 8.6 6.9 1.5 1 1 0 1 1 1 0 HrpJ-like domain U79_P34 PF03064.11 EWC43579.1 - 8.7 5.7 11.3 11 5.4 7.8 1.1 1 0 0 1 1 1 0 HSV U79 / HCMV P34 Kinesin PF00225.18 EWC43581.1 - 2.3e-114 381.5 0.0 3.8e-114 380.8 0.0 1.4 1 0 0 1 1 1 1 Kinesin motor domain AAA_33 PF13671.1 EWC43581.1 - 0.044 13.6 0.0 0.12 12.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain PPI_Ypi1 PF07491.6 EWC43581.1 - 0.084 12.5 0.4 0.25 10.9 0.3 1.8 1 0 0 1 1 1 0 Protein phosphatase inhibitor V_ATPase_I PF01496.14 EWC43581.1 - 0.53 8.0 3.4 1.1 7.0 2.3 1.4 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RRM_1 PF00076.17 EWC43582.1 - 4.3e-16 58.3 0.0 6.7e-16 57.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EWC43582.1 - 6.5e-11 42.0 0.0 9.9e-11 41.4 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EWC43582.1 - 4.1e-10 39.3 0.0 7e-10 38.6 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 EWC43582.1 - 0.013 15.3 0.0 0.02 14.7 0.0 1.3 1 0 0 1 1 1 0 RNA binding motif Myb_DNA-binding PF00249.26 EWC43583.1 - 8.3e-13 48.1 3.7 6.6e-07 29.2 1.3 2.8 2 1 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 EWC43583.1 - 1.6e-11 44.1 3.1 4.8e-06 26.5 1.0 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain PAT1 PF09770.4 EWC43583.1 - 0.04 12.1 16.8 0.041 12.1 11.7 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Ndc1_Nup PF09531.5 EWC43583.1 - 2.3 6.5 5.7 2.7 6.3 3.9 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup TFIIA PF03153.8 EWC43583.1 - 2.9 7.7 8.0 3.7 7.3 5.6 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Malic_M PF03949.10 EWC43585.1 - 3.3e-78 262.7 0.1 4.9e-78 262.2 0.1 1.2 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.14 EWC43585.1 - 1.1e-63 214.0 0.0 1.7e-63 213.4 0.0 1.3 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain Oxidored_nitro PF00148.14 EWC43585.1 - 0.065 11.8 0.0 0.096 11.3 0.0 1.2 1 0 0 1 1 1 0 Nitrogenase component 1 type Oxidoreductase Myb_DNA-bind_6 PF13921.1 EWC43586.1 - 6.6e-06 26.1 1.3 0.0014 18.6 0.5 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 EWC43586.1 - 0.019 15.0 4.8 3.5 7.7 1.5 3.5 3 1 0 3 3 3 0 Myb-like DNA-binding domain MADF_DNA_bdg PF10545.4 EWC43586.1 - 0.085 13.0 3.4 6.6 6.9 0.7 2.4 2 0 0 2 2 2 0 Alcohol dehydrogenase transcription factor Myb/SANT-like RNA_pol_Rpc34 PF05158.7 EWC43587.1 - 2.6e-91 306.2 0.0 7.5e-91 304.7 0.0 1.6 1 1 0 1 1 1 1 RNA polymerase Rpc34 subunit HxlR PF01638.12 EWC43587.1 - 0.0056 16.2 0.2 0.018 14.6 0.2 1.9 2 1 0 2 2 2 1 HxlR-like helix-turn-helix PadR PF03551.9 EWC43587.1 - 0.1 12.3 0.1 0.27 11.0 0.1 1.7 2 0 0 2 2 2 0 Transcriptional regulator PadR-like family PPTA PF01239.17 EWC43588.1 - 4.7e-06 25.7 5.5 0.013 14.8 0.3 3.5 3 0 0 3 3 3 2 Protein prenyltransferase alpha subunit repeat Kelch_3 PF13415.1 EWC43589.1 - 8.9e-25 86.2 11.0 2.6e-08 33.7 0.1 6.7 6 1 0 6 6 6 3 Galactose oxidase, central domain Kelch_4 PF13418.1 EWC43589.1 - 2.7e-23 81.4 22.0 5.6e-08 32.4 0.2 7.2 6 2 1 7 7 7 5 Galactose oxidase, central domain DUF4110 PF13422.1 EWC43589.1 - 9.4e-21 73.4 0.2 9.4e-21 73.4 0.2 3.6 5 0 0 5 5 5 1 Domain of unknown function (DUF4110) Kelch_5 PF13854.1 EWC43589.1 - 7.5e-16 57.7 5.1 6e-05 22.9 0.1 6.3 6 0 0 6 6 6 3 Kelch motif Kelch_6 PF13964.1 EWC43589.1 - 2.1e-15 56.1 11.2 6.7e-07 29.2 0.2 5.6 5 1 1 6 6 6 3 Kelch motif Kelch_2 PF07646.10 EWC43589.1 - 2.5e-12 46.0 6.6 1.7e-05 24.3 0.0 6.1 6 0 0 6 6 6 1 Kelch motif Kelch_1 PF01344.20 EWC43589.1 - 1.1e-10 40.8 9.0 1.2e-06 27.9 0.0 4.9 4 0 0 4 4 4 2 Kelch motif Nop14 PF04147.7 EWC43589.1 - 1.1e-05 23.6 9.8 1.1e-05 23.6 6.8 2.1 2 0 0 2 2 2 1 Nop14-like family CDC45 PF02724.9 EWC43589.1 - 0.00027 19.1 8.7 0.00027 19.1 6.1 2.1 2 0 0 2 2 2 1 CDC45-like protein YL1 PF05764.8 EWC43589.1 - 0.0084 15.7 11.8 0.0084 15.7 8.2 2.6 2 0 0 2 2 2 1 YL1 nuclear protein Oxysterol_BP PF01237.13 EWC43590.1 - 4.3e-89 298.4 0.0 5.4e-89 298.1 0.0 1.0 1 0 0 1 1 1 1 Oxysterol-binding protein Tim17 PF02466.14 EWC43591.1 - 0.052 13.6 2.6 0.42 10.6 2.0 2.1 1 1 1 2 2 2 0 Tim17/Tim22/Tim23/Pmp24 family DUF4203 PF13886.1 EWC43591.1 - 0.38 10.1 3.9 0.32 10.4 1.8 1.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4203) HATPase_c PF02518.21 EWC43592.1 - 1.7e-27 95.3 0.0 3.4e-27 94.3 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MHYT PF03707.11 EWC43592.1 - 1e-24 86.3 22.5 3.9e-11 42.8 0.6 4.4 4 0 0 4 4 4 3 Bacterial signalling protein N terminal repeat Response_reg PF00072.19 EWC43592.1 - 6.5e-18 64.7 0.0 1.6e-17 63.4 0.0 1.7 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.20 EWC43592.1 - 1.9e-14 53.4 0.0 4.8e-14 52.0 0.0 1.8 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_2 PF13581.1 EWC43592.1 - 0.0017 18.1 0.0 0.005 16.6 0.0 1.8 2 0 0 2 2 2 1 Histidine kinase-like ATPase domain DUF422 PF04240.7 EWC43592.1 - 0.22 10.9 8.8 0.012 14.9 1.4 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF422) PDR_CDR PF06422.7 EWC43592.1 - 0.23 11.1 2.4 1.4 8.5 0.1 2.9 3 0 0 3 3 3 0 CDR ABC transporter CcmD PF04995.9 EWC43592.1 - 2.8 7.7 5.7 46 3.8 0.2 3.8 3 0 0 3 3 3 0 Heme exporter protein D (CcmD) PMSR PF01625.16 EWC43593.1 - 2e-56 190.2 2.3 2.5e-56 189.8 1.6 1.1 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase Phage_GPA PF05840.8 EWC43593.1 - 0.03 13.0 0.1 0.039 12.6 0.1 1.1 1 0 0 1 1 1 0 Bacteriophage replication gene A protein (GPA) TPR_11 PF13414.1 EWC43594.1 - 1.8e-56 187.6 21.9 1.6e-16 59.7 0.0 6.2 5 1 0 6 6 6 5 TPR repeat TPR_1 PF00515.23 EWC43594.1 - 1.1e-47 157.7 19.1 2e-07 30.3 0.0 9.4 9 0 0 9 9 9 9 Tetratricopeptide repeat TPR_2 PF07719.12 EWC43594.1 - 1.9e-39 130.3 19.0 1.1e-05 24.8 0.0 9.5 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_12 PF13424.1 EWC43594.1 - 2.2e-24 85.1 10.0 2.7e-12 46.4 1.0 5.6 3 2 2 5 5 5 4 Tetratricopeptide repeat TPR_16 PF13432.1 EWC43594.1 - 1.7e-22 79.4 12.9 0.00065 20.3 0.0 6.5 4 2 2 6 6 6 6 Tetratricopeptide repeat TPR_14 PF13428.1 EWC43594.1 - 1.2e-21 75.2 16.7 0.012 16.1 0.0 9.3 5 3 5 10 10 9 6 Tetratricopeptide repeat TPR_8 PF13181.1 EWC43594.1 - 2.4e-16 58.1 13.0 0.009 15.7 0.1 8.4 8 1 1 9 9 8 4 Tetratricopeptide repeat TPR_7 PF13176.1 EWC43594.1 - 1.8e-15 55.4 10.5 8.3e-05 22.0 0.0 7.2 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_17 PF13431.1 EWC43594.1 - 1.4e-14 53.0 8.1 0.029 14.5 0.0 8.7 9 0 0 9 9 8 2 Tetratricopeptide repeat TPR_19 PF14559.1 EWC43594.1 - 5e-13 49.1 11.2 0.01 16.1 0.0 7.0 6 1 1 7 7 7 3 Tetratricopeptide repeat TPR_9 PF13371.1 EWC43594.1 - 1.8e-09 37.2 1.2 0.089 12.6 0.0 4.8 4 1 1 5 5 5 3 Tetratricopeptide repeat Apc3 PF12895.2 EWC43594.1 - 2.5e-07 30.7 7.8 0.077 13.1 1.5 4.5 3 1 1 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.1 EWC43594.1 - 5.2e-06 26.5 15.5 0.065 13.7 0.1 7.6 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_3 PF07720.7 EWC43594.1 - 8e-05 22.3 4.2 0.52 10.1 0.1 4.5 5 0 0 5 5 5 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 EWC43594.1 - 0.00013 21.7 2.8 25 4.8 0.0 6.1 6 0 0 6 6 6 0 Fis1 C-terminal tetratricopeptide repeat TPR_10 PF13374.1 EWC43594.1 - 0.0014 18.4 7.5 1.6 8.7 0.0 5.9 7 0 0 7 7 7 1 Tetratricopeptide repeat RPN7 PF10602.4 EWC43594.1 - 0.0055 16.1 6.6 1.2 8.5 0.0 4.1 4 1 1 5 5 5 2 26S proteasome subunit RPN7 TPR_20 PF14561.1 EWC43594.1 - 0.41 10.7 10.9 1.5 8.9 0.1 4.9 5 2 2 7 7 7 0 Tetratricopeptide repeat SHNi-TPR PF10516.4 EWC43594.1 - 1.6 8.0 5.2 3.7 6.8 0.0 4.1 6 0 0 6 6 6 0 SHNi-TPR cNMP_binding PF00027.24 EWC43595.1 - 4.7e-35 119.2 0.0 3.3e-18 65.2 0.0 2.5 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain LRR_6 PF13516.1 EWC43595.1 - 9.4e-13 46.8 4.4 3.8 7.8 0.0 8.8 9 0 0 9 9 9 2 Leucine Rich repeat LRR_1 PF00560.28 EWC43595.1 - 3.2e-09 35.5 1.4 22 5.5 0.0 8.5 8 1 0 8 8 8 0 Leucine Rich Repeat LRR_4 PF12799.2 EWC43595.1 - 1.7e-07 30.7 0.1 0.15 11.6 0.0 5.7 6 0 0 6 6 6 1 Leucine Rich repeats (2 copies) F-box PF00646.28 EWC43595.1 - 2e-06 27.3 1.2 3.5e-05 23.3 0.2 2.9 2 0 0 2 2 2 1 F-box domain LRR_8 PF13855.1 EWC43595.1 - 7.7e-06 25.5 0.5 0.13 12.0 1.1 4.9 3 1 1 5 5 5 1 Leucine rich repeat F-box-like PF12937.2 EWC43595.1 - 8.7e-05 22.1 1.1 0.00043 19.9 0.1 2.7 3 0 0 3 3 3 1 F-box-like Cupin_3 PF05899.7 EWC43595.1 - 0.0026 17.0 0.1 0.39 10.1 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF861) LRR_7 PF13504.1 EWC43595.1 - 0.36 11.2 13.7 90 3.9 0.0 7.8 8 1 0 8 8 8 0 Leucine rich repeat CHAT PF12770.2 EWC43596.1 - 8.9e-14 51.2 0.0 1.5e-13 50.5 0.0 1.3 1 0 0 1 1 1 1 CHAT domain DUF4164 PF13747.1 EWC43597.1 - 0.00022 21.2 11.2 0.011 15.7 4.5 2.7 2 0 0 2 2 2 2 Domain of unknown function (DUF4164) AAA_13 PF13166.1 EWC43597.1 - 0.00039 19.0 6.5 0.00052 18.6 4.5 1.1 1 0 0 1 1 1 1 AAA domain Ax_dynein_light PF10211.4 EWC43597.1 - 0.0049 16.7 0.8 0.0049 16.7 0.5 2.4 2 0 0 2 2 2 1 Axonemal dynein light chain MbeD_MobD PF04899.7 EWC43597.1 - 0.041 13.7 4.2 0.04 13.8 0.6 2.9 4 0 0 4 4 4 0 MbeD/MobD like TMF_DNA_bd PF12329.3 EWC43597.1 - 0.17 11.7 13.2 1.1 9.1 0.2 3.6 1 1 2 3 3 3 0 TATA element modulatory factor 1 DNA binding Lzipper-MIP1 PF14389.1 EWC43597.1 - 0.33 11.0 9.7 0.38 10.9 3.9 2.9 2 1 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 Fib_alpha PF08702.5 EWC43597.1 - 2.6 8.1 7.4 1.2 9.2 2.9 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family FlxA PF14282.1 EWC43597.1 - 4.1 7.3 21.0 2.8 7.9 0.0 3.9 3 1 0 3 3 3 0 FlxA-like protein SlyX PF04102.7 EWC43597.1 - 6.7 7.1 10.7 31 5.0 0.0 4.1 1 1 1 4 4 4 0 SlyX NUDIX PF00293.23 EWC43598.1 - 8.3e-15 54.6 0.0 1.9e-12 46.9 0.0 2.2 2 0 0 2 2 2 2 NUDIX domain C2 PF00168.25 EWC43599.1 - 1.5e-68 226.6 2.6 1.4e-19 69.7 0.0 4.8 5 0 0 5 5 5 4 C2 domain 2OG-FeII_Oxy PF03171.15 EWC43600.1 - 4.6e-05 23.6 0.0 0.0008 19.6 0.0 2.4 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily MFS_1 PF07690.11 EWC43602.1 - 1.3e-38 132.6 26.7 3.5e-30 104.9 0.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EWC43602.1 - 2.4e-08 32.9 4.0 2.4e-08 32.9 2.8 2.2 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_2 PF13347.1 EWC43602.1 - 1.1e-05 24.0 0.2 1.1e-05 24.0 0.1 2.4 2 1 0 2 2 2 1 MFS/sugar transport protein TRI12 PF06609.8 EWC43602.1 - 0.0047 15.1 0.8 0.0047 15.1 0.5 1.6 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Zip PF02535.17 EWC43602.1 - 0.096 11.6 0.0 0.096 11.6 0.0 2.2 2 0 0 2 2 2 0 ZIP Zinc transporter Fungal_trans PF04082.13 EWC43603.1 - 2.6e-18 65.8 0.1 6.2e-18 64.5 0.1 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EWC43603.1 - 1.1e-07 31.6 10.3 2.1e-07 30.7 7.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CGI-121 PF08617.5 EWC43604.1 - 2.3e-43 147.6 0.0 2.6e-43 147.4 0.0 1.0 1 0 0 1 1 1 1 Kinase binding protein CGI-121 F-box PF00646.28 EWC43605.1 - 1.7e-05 24.3 0.0 3.4e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 EWC43605.1 - 0.0027 17.3 0.0 0.0054 16.4 0.0 1.4 1 0 0 1 1 1 1 F-box-like HMG-CoA_red PF00368.13 EWC43606.1 - 1.6e-158 527.2 3.9 2.6e-158 526.5 2.7 1.3 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase HPIH PF13323.1 EWC43606.1 - 3.1e-20 72.4 0.3 7.5e-20 71.1 0.2 1.6 1 0 0 1 1 1 1 N-terminal domain with HPIH motif Sterol-sensing PF12349.3 EWC43606.1 - 9e-14 51.2 3.9 6.6e-13 48.3 2.7 2.2 1 1 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.13 EWC43606.1 - 8e-06 24.0 0.3 8e-06 24.0 0.2 1.4 2 0 0 2 2 2 1 Patched family DUF2304 PF10066.4 EWC43606.1 - 0.018 14.8 0.2 0.087 12.6 0.1 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2304) Ribosomal_S21e PF01249.13 EWC43607.1 - 1.9e-40 136.6 0.1 2.1e-40 136.5 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S21e SH3_9 PF14604.1 EWC43609.1 - 1.3e-10 40.6 0.2 2.3e-10 39.8 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 EWC43609.1 - 8.7e-10 37.8 0.0 1.7e-09 36.9 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.12 EWC43609.1 - 3.5e-06 26.4 0.1 6.5e-06 25.5 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain CobT PF06213.7 EWC43609.1 - 3.9 6.5 7.9 6.1 5.8 5.5 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Ssu72 PF04722.8 EWC43610.1 - 7.7e-83 276.6 0.0 9.9e-83 276.2 0.0 1.1 1 0 0 1 1 1 1 Ssu72-like protein GIT_SHD PF08518.6 EWC43611.1 - 1.4e-23 81.9 6.9 7.7e-14 50.7 0.7 2.7 2 0 0 2 2 2 2 Spa2 homology domain (SHD) of GIT APG6 PF04111.7 EWC43611.1 - 0.18 10.8 27.5 0.26 10.2 6.3 2.8 1 1 1 2 2 2 0 Autophagy protein Apg6 Transp_cyt_pur PF02133.10 EWC43612.1 - 1.5e-47 162.2 32.0 1.8e-47 161.8 22.2 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Cellulase PF00150.13 EWC43613.1 - 4.2e-15 55.6 0.6 6.9e-15 54.9 0.0 1.5 2 0 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_42 PF02449.10 EWC43613.1 - 0.0024 17.0 0.1 0.031 13.3 0.1 2.3 2 0 0 2 2 2 1 Beta-galactosidase AAA_23 PF13476.1 EWC43614.1 - 1.9e-28 100.1 1.5 1.9e-28 100.1 1.1 7.6 3 2 1 4 4 4 1 AAA domain SbcCD_C PF13558.1 EWC43614.1 - 1e-10 41.3 0.0 3.2e-10 39.7 0.0 1.9 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_21 PF13304.1 EWC43614.1 - 9.2e-09 35.6 3.0 0.0013 18.7 0.0 3.6 3 0 0 3 3 3 2 AAA domain AAA_13 PF13166.1 EWC43614.1 - 7.5e-08 31.3 115.4 0.00025 19.6 0.0 7.5 2 1 5 7 7 7 5 AAA domain SMC_N PF02463.14 EWC43614.1 - 0.00041 19.6 49.3 0.0029 16.8 34.2 2.5 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 EWC43614.1 - 0.00083 18.8 0.0 0.0018 17.7 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.1 EWC43614.1 - 0.0019 17.2 10.1 0.0029 16.7 4.7 4.5 3 2 1 4 4 4 2 AAA ATPase domain MobB PF03205.9 EWC43614.1 - 0.039 13.6 1.7 0.24 11.1 0.0 3.2 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B GATA PF00320.22 EWC43615.1 - 1.3e-15 56.3 5.4 2.7e-15 55.4 3.7 1.5 1 0 0 1 1 1 1 GATA zinc finger PAS_9 PF13426.1 EWC43615.1 - 6.5e-13 48.9 0.1 8e-12 45.4 0.0 2.3 2 0 0 2 2 2 1 PAS domain PAS_3 PF08447.6 EWC43615.1 - 8.1e-12 45.0 0.1 1.7e-11 44.0 0.0 1.5 1 0 0 1 1 1 1 PAS fold PAS PF00989.19 EWC43615.1 - 3.9e-11 42.7 0.5 8.7e-11 41.6 0.0 1.8 2 0 0 2 2 2 1 PAS fold PAS_11 PF14598.1 EWC43615.1 - 1.1e-07 31.7 0.2 2.3e-07 30.7 0.0 1.6 2 0 0 2 2 2 1 PAS domain PAS_4 PF08448.5 EWC43615.1 - 1.1e-05 25.4 0.0 2.3e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 PAS fold TF_Zn_Ribbon PF08271.7 EWC43615.1 - 0.048 12.9 0.8 0.27 10.6 0.1 2.3 2 0 0 2 2 2 0 TFIIB zinc-binding DUF4448 PF14610.1 EWC43616.1 - 0.11 11.9 0.2 17 4.8 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4448) RCR PF12273.3 EWC43616.1 - 0.23 12.0 2.5 29 5.2 0.0 3.2 2 0 0 2 2 2 0 Chitin synthesis regulation, resistance to Congo red NPR2 PF06218.6 EWC43617.1 - 2.2e-120 402.2 4.2 2.8e-115 385.4 1.6 2.1 1 1 1 2 2 2 2 Nitrogen permease regulator 2 NPR3 PF03666.8 EWC43617.1 - 1.1e-05 24.1 0.2 0.16 10.5 0.1 2.8 2 1 1 3 3 3 2 Nitrogen Permease regulator of amino acid transport activity 3 Afi1 PF07792.7 EWC43617.1 - 0.059 13.3 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking ADH_zinc_N PF00107.21 EWC43618.1 - 1.4e-19 69.8 0.1 2.1e-19 69.3 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 EWC43618.1 - 0.0009 20.1 0.0 0.0016 19.3 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase PGM_PMM_II PF02879.11 EWC43618.1 - 0.11 12.8 0.0 0.27 11.5 0.0 1.8 1 0 0 1 1 1 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II Maf PF02545.9 EWC43619.1 - 1.8e-47 161.0 0.0 2.4e-47 160.5 0.0 1.1 1 0 0 1 1 1 1 Maf-like protein Peptidase_M28 PF04389.12 EWC43621.1 - 6e-17 61.9 0.8 7.1e-16 58.4 0.5 2.3 1 1 0 1 1 1 1 Peptidase family M28 TFR_dimer PF04253.10 EWC43621.1 - 3.5e-16 58.9 0.0 6.2e-16 58.1 0.0 1.4 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain PA PF02225.17 EWC43621.1 - 2.7e-07 30.2 0.0 6.6e-07 28.9 0.0 1.7 1 0 0 1 1 1 1 PA domain Nicastrin PF05450.10 EWC43621.1 - 0.014 14.6 0.0 0.025 13.8 0.0 1.3 1 0 0 1 1 1 0 Nicastrin Peptidase_M20 PF01546.23 EWC43621.1 - 0.35 10.3 2.5 0.79 9.1 1.8 1.6 1 1 0 1 1 1 0 Peptidase family M20/M25/M40 MFS_1 PF07690.11 EWC43622.1 - 2.4e-16 59.3 20.4 2.4e-16 59.3 14.1 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF788 PF05620.6 EWC43622.1 - 0.76 9.6 0.0 0.76 9.6 0.0 2.9 4 0 0 4 4 4 0 Protein of unknown function (DUF788) Zn_clus PF00172.13 EWC43623.1 - 3.9e-05 23.4 10.9 7.1e-05 22.6 7.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 EWC43623.1 - 0.0013 17.6 0.0 0.0032 16.3 0.0 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain Macoilin PF09726.4 EWC43623.1 - 0.23 9.6 6.8 0.4 8.9 4.7 1.2 1 0 0 1 1 1 0 Transmembrane protein SNF2_N PF00176.18 EWC43625.1 - 6.4e-53 179.4 0.0 9.4e-53 178.9 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain VIGSSK PF14773.1 EWC43625.1 - 4.3e-21 74.5 0.8 1.5e-20 72.8 0.5 2.0 1 0 0 1 1 1 1 Helicase-associated putative binding domain, C-terminal Helicase_C PF00271.26 EWC43625.1 - 4.3e-15 55.3 0.0 1.4e-14 53.7 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HDA2-3 PF11496.3 EWC43625.1 - 0.00011 21.1 0.0 0.0045 15.8 0.0 2.4 2 0 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 Rad1 PF02144.11 EWC43626.1 - 4.7e-64 215.8 0.2 1.4e-37 128.9 0.1 2.1 2 0 0 2 2 2 2 Repair protein Rad1/Rec1/Rad17 CENP-B_dimeris PF09026.5 EWC43626.1 - 6.8 6.9 11.4 13 6.0 7.9 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Ank_2 PF12796.2 EWC43627.1 - 1.9e-60 201.1 14.2 1.9e-18 66.5 0.1 4.9 2 1 2 5 5 4 4 Ankyrin repeats (3 copies) Ank PF00023.25 EWC43627.1 - 2.7e-47 156.2 20.2 6.5e-06 25.6 0.0 9.8 9 0 0 9 9 9 9 Ankyrin repeat Ank_4 PF13637.1 EWC43627.1 - 7e-33 112.4 9.6 3.6e-07 30.5 0.0 7.7 5 1 3 8 8 8 7 Ankyrin repeats (many copies) Ank_3 PF13606.1 EWC43627.1 - 5.4e-32 106.6 10.7 0.00046 20.1 0.0 10.2 9 0 0 9 9 9 8 Ankyrin repeat Ank_5 PF13857.1 EWC43627.1 - 1.4e-21 76.0 11.5 0.00033 20.7 0.1 6.9 2 1 3 6 6 6 6 Ankyrin repeats (many copies) NACHT PF05729.7 EWC43627.1 - 6.4e-11 42.1 0.1 1.2e-10 41.3 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.1 EWC43627.1 - 2.3e-08 34.2 0.0 6.9e-08 32.6 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain Arch_ATPase PF01637.13 EWC43627.1 - 3e-07 30.4 0.0 8.1e-07 28.9 0.0 1.7 1 0 0 1 1 1 1 Archaeal ATPase PNP_UDP_1 PF01048.15 EWC43627.1 - 3.6e-06 26.1 0.1 1.5e-05 24.1 0.1 1.9 1 1 0 1 1 1 1 Phosphorylase superfamily AAA_14 PF13173.1 EWC43627.1 - 1.4e-05 24.9 0.9 0.00033 20.5 0.1 3.1 2 1 0 2 2 2 1 AAA domain AAA_22 PF13401.1 EWC43627.1 - 1.6e-05 25.0 0.5 8.5e-05 22.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA PF00004.24 EWC43627.1 - 0.0033 17.6 0.0 0.011 15.9 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) KAP_NTPase PF07693.9 EWC43627.1 - 0.0051 15.8 0.1 1.2 8.0 0.0 2.4 1 1 1 2 2 2 1 KAP family P-loop domain NB-ARC PF00931.17 EWC43627.1 - 0.0064 15.3 0.0 0.012 14.4 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain RNA_helicase PF00910.17 EWC43627.1 - 0.0067 16.5 0.1 0.056 13.6 0.0 2.4 2 0 0 2 2 2 1 RNA helicase KaiC PF06745.8 EWC43627.1 - 0.03 13.4 0.0 0.069 12.2 0.0 1.5 1 0 0 1 1 1 0 KaiC DUF1843 PF08898.5 EWC43627.1 - 5.7 7.0 9.2 7.2 6.7 0.0 4.5 5 0 0 5 5 4 0 Domain of unknown function (DUF1843) Pro_isomerase PF00160.16 EWC43628.1 - 5.9e-45 153.2 0.9 6.5e-45 153.1 0.6 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DUF155 PF02582.9 EWC43629.1 - 3.4e-63 212.7 0.1 5.4e-63 212.0 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 RGS PF00615.14 EWC43630.1 - 1.8e-13 50.6 0.0 1.9e-10 40.8 0.0 2.2 2 0 0 2 2 2 2 Regulator of G protein signaling domain Ribosomal_L21e PF01157.13 EWC43632.1 - 0.14 11.9 0.5 0.34 10.7 0.2 1.8 2 0 0 2 2 2 0 Ribosomal protein L21e INTS2 PF14750.1 EWC43632.1 - 0.17 9.3 0.2 0.21 9.0 0.1 1.0 1 0 0 1 1 1 0 Integrator complex subunit 2 Bromodomain PF00439.20 EWC43633.1 - 1.1e-24 86.1 0.4 2.2e-24 85.1 0.3 1.6 1 0 0 1 1 1 1 Bromodomain Acetyltransf_7 PF13508.1 EWC43633.1 - 3.9e-09 36.5 0.2 7.5e-09 35.6 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 EWC43633.1 - 5.3e-09 35.9 0.0 1e-08 35.0 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Sugar_tr PF00083.19 EWC43634.1 - 3.6e-83 279.6 27.6 4.1e-83 279.4 19.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EWC43634.1 - 2.5e-28 98.8 33.0 2.5e-28 98.8 22.9 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_1_like PF12832.2 EWC43634.1 - 0.0041 16.8 0.3 0.022 14.5 0.0 2.4 2 0 0 2 2 2 1 MFS_1 like family OATP PF03137.15 EWC43634.1 - 0.057 11.4 11.9 0.54 8.2 0.1 3.2 2 1 0 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family Peptidase_S8 PF00082.17 EWC43635.1 - 2.9e-39 134.9 2.1 4.9e-39 134.1 1.5 1.3 1 0 0 1 1 1 1 Subtilase family Peptidase_M28 PF04389.12 EWC43637.1 - 2e-33 115.6 0.0 3.3e-33 114.9 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.17 EWC43637.1 - 7.6e-15 54.4 0.5 2.2e-14 52.9 0.3 1.8 1 0 0 1 1 1 1 PA domain Peptidase_M20 PF01546.23 EWC43637.1 - 0.0019 17.7 0.0 0.0032 16.9 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 DUF1349 PF07081.6 EWC43638.1 - 5.4e-12 45.4 0.0 7.4e-12 44.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1349) CLTH PF10607.4 EWC43639.1 - 2.4e-35 121.3 0.0 5.5e-35 120.1 0.0 1.6 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain SPRY PF00622.23 EWC43639.1 - 1.3e-26 93.1 0.4 2.7e-26 92.0 0.1 1.6 2 0 0 2 2 2 1 SPRY domain LisH PF08513.6 EWC43639.1 - 7.6e-06 25.5 0.0 1.7e-05 24.3 0.0 1.7 1 0 0 1 1 1 1 LisH Ribosomal_L31e PF01198.14 EWC43640.1 - 2.6e-37 126.3 3.0 4.7e-37 125.5 2.1 1.5 1 0 0 1 1 1 1 Ribosomal protein L31e Lactamase_B_2 PF12706.2 EWC43640.1 - 1.1e-10 41.4 0.0 2.2e-10 40.4 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.22 EWC43640.1 - 4.8e-06 26.3 0.0 1.1e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily DRMBL PF07522.9 EWC43640.1 - 5.5e-06 26.4 0.0 2.2e-05 24.4 0.0 2.1 2 0 0 2 2 2 1 DNA repair metallo-beta-lactamase Proteasom_Rpn13 PF04683.8 EWC43641.1 - 2.7e-20 72.2 0.0 3.9e-20 71.7 0.0 1.3 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor DUF1656 PF07869.7 EWC43642.1 - 0.14 11.9 0.7 0.26 11.1 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1656) tRNA-synt_2b PF00587.20 EWC43643.1 - 5.9e-44 149.6 0.1 1.2e-43 148.7 0.1 1.5 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 EWC43643.1 - 0.0056 16.5 0.3 0.063 13.2 0.0 2.3 2 0 0 2 2 2 1 Anticodon binding domain HLH PF00010.21 EWC43644.1 - 8.6e-07 28.5 1.3 1.4e-06 27.9 0.0 1.9 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain zf-CCCH PF00642.19 EWC43645.1 - 1.5e-09 37.2 18.4 2.8e-07 30.0 1.5 3.2 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_5 PF13893.1 EWC43645.1 - 1.2e-06 28.2 0.0 2.2e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 EWC43645.1 - 0.00035 20.1 0.0 0.00055 19.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EWC43645.1 - 0.025 14.5 0.0 0.071 13.1 0.0 1.7 1 1 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) zf-SAP30 PF13866.1 EWC43645.1 - 0.1 12.2 1.0 1.1 8.9 0.2 2.2 2 0 0 2 2 2 0 SAP30 zinc-finger SCRG1 PF15224.1 EWC43645.1 - 0.24 11.2 5.2 0.63 9.8 0.3 2.4 2 0 0 2 2 2 0 Scrapie-responsive protein 1 CTNNBL PF08216.6 EWC43646.1 - 1.9e-36 123.8 0.3 2.6e-35 120.2 0.0 2.5 2 0 0 2 2 2 1 Catenin-beta-like, Arm-motif containing nuclear E3_UbLigase_R4 PF13764.1 EWC43646.1 - 0.0013 16.7 0.9 0.0035 15.3 0.2 1.8 2 0 0 2 2 2 1 E3 ubiquitin-protein ligase UBR4 Arm PF00514.18 EWC43646.1 - 0.0055 16.4 0.6 6.2 6.7 0.0 3.2 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat MMS19_C PF12460.3 EWC43646.1 - 0.079 11.6 0.1 6.8 5.2 0.0 3.3 4 0 0 4 4 4 0 RNAPII transcription regulator C-terminal Mem_trans PF03547.13 EWC43647.1 - 1.7e-28 99.0 4.4 2.2e-28 98.6 3.1 1.0 1 0 0 1 1 1 1 Membrane transport protein DUF4018 PF13210.1 EWC43647.1 - 0.022 14.1 0.5 0.23 10.8 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4018) TcpE PF12648.2 EWC43647.1 - 2.2 8.4 9.6 0.52 10.4 0.3 3.5 3 1 0 3 3 3 0 TcpE family TEA PF01285.13 EWC43648.1 - 2.4e-46 158.8 0.8 2.9e-46 158.5 0.2 1.4 1 1 0 1 1 1 1 TEA/ATTS domain family DUF1043 PF06295.7 EWC43648.1 - 0.003 17.1 0.1 0.99 9.0 0.0 2.9 2 0 0 2 2 2 2 Protein of unknown function (DUF1043) F-box-like PF12937.2 EWC43649.1 - 0.016 14.8 0.9 0.029 14.0 0.7 1.4 1 0 0 1 1 1 0 F-box-like F-box-like PF12937.2 EWC43651.1 - 0.0029 17.2 2.6 0.0044 16.7 0.8 2.0 2 0 0 2 2 2 1 F-box-like F-box PF00646.28 EWC43651.1 - 0.085 12.5 0.2 0.2 11.3 0.1 1.6 1 0 0 1 1 1 0 F-box domain MGC-24 PF05283.6 EWC43652.1 - 4.6 6.9 6.0 7.3 6.3 4.2 1.2 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24) Transposase_28 PF04195.7 EWC43653.1 - 0.04 13.2 0.0 0.1 11.9 0.0 1.6 1 0 0 1 1 1 0 Putative gypsy type transposon SPDY PF03771.11 EWC43653.1 - 0.061 12.8 0.1 0.18 11.3 0.1 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF317) Metallophos PF00149.23 EWC43654.1 - 2.5e-08 33.5 2.6 1.8e-07 30.7 1.8 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 EWC43654.1 - 2.7e-07 30.5 0.0 3.9e-07 30.0 0.0 1.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain DUF924 PF06041.6 EWC43655.1 - 7.7e-39 133.3 0.0 1.2e-38 132.7 0.0 1.3 1 1 0 1 1 1 1 Bacterial protein of unknown function (DUF924) Pkinase PF00069.20 EWC43655.1 - 0.059 12.5 0.4 0.083 12.0 0.2 1.2 1 0 0 1 1 1 0 Protein kinase domain DUF494 PF04361.8 EWC43655.1 - 0.068 12.8 0.1 0.12 12.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF494) Fungal_trans_2 PF11951.3 EWC43656.1 - 3.2e-05 22.7 1.9 3.9e-05 22.4 0.4 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain ubiquitin PF00240.18 EWC43658.1 - 3.4e-21 74.4 0.0 8.9e-21 73.0 0.0 1.8 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 EWC43658.1 - 2e-11 43.4 0.0 3.7e-11 42.5 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like zf-C2H2_4 PF13894.1 EWC43659.1 - 3.7e-09 36.2 10.9 0.012 15.8 0.0 3.9 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2 PF00096.21 EWC43659.1 - 1.6e-07 31.2 13.7 0.0079 16.4 0.1 3.6 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_6 PF13912.1 EWC43659.1 - 0.0094 15.8 2.5 1.8 8.6 0.2 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 EWC43659.1 - 0.96 9.6 5.3 14 5.9 0.3 2.6 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.1 EWC43659.1 - 4.5 7.7 22.3 0.077 13.3 3.3 3.6 4 0 0 4 4 4 0 Zinc-finger double domain IncA PF04156.9 EWC43660.1 - 0.0068 16.0 0.6 0.0068 16.0 0.4 2.8 3 0 0 3 3 3 1 IncA protein DUF3912 PF13051.1 EWC43661.1 - 0.0015 18.2 0.6 0.95 9.2 0.2 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF3912) WEMBL PF05701.6 EWC43661.1 - 0.28 9.6 13.6 0.032 12.7 1.2 2.1 2 0 0 2 2 2 0 Weak chloroplast movement under blue light BLOC1_2 PF10046.4 EWC43661.1 - 0.79 9.9 5.1 5.2 7.2 0.2 3.0 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 IncA PF04156.9 EWC43661.1 - 2.2 7.8 6.9 8.6 5.9 0.2 2.2 2 0 0 2 2 2 0 IncA protein FadA PF09403.5 EWC43661.1 - 4.2 7.3 8.2 1.5 8.8 1.6 2.4 2 1 0 2 2 2 0 Adhesion protein FadA HWE_HK PF07536.9 EWC43662.1 - 0.018 15.4 2.7 0.028 14.8 1.9 1.3 1 0 0 1 1 1 0 HWE histidine kinase Pkinase PF00069.20 EWC43664.1 - 7.4e-72 241.6 0.0 1.1e-71 241.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC43664.1 - 1.8e-36 125.5 0.0 3.8e-36 124.4 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EWC43664.1 - 0.00055 18.9 0.1 0.36 9.7 0.0 2.4 2 0 0 2 2 2 2 Kinase-like APH PF01636.18 EWC43664.1 - 0.0012 18.6 0.7 0.013 15.2 0.0 2.6 2 1 1 3 3 3 2 Phosphotransferase enzyme family Tom22 PF04281.8 EWC43667.1 - 0.0034 16.9 2.4 0.0064 16.0 1.6 1.4 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom22 FAM176 PF14851.1 EWC43667.1 - 0.1 12.3 1.3 1.1 8.9 0.3 2.4 2 0 0 2 2 2 0 FAM176 family ANTH PF07651.11 EWC43667.1 - 0.1 11.3 0.0 0.24 10.0 0.0 1.6 1 0 0 1 1 1 0 ANTH domain RXT2_N PF08595.6 EWC43667.1 - 0.23 11.2 1.4 0.51 10.1 0.9 1.5 1 0 0 1 1 1 0 RXT2-like, N-terminal DUF2457 PF10446.4 EWC43667.1 - 1.1 7.8 9.8 1.9 7.0 6.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Cwf_Cwc_15 PF04889.7 EWC43667.1 - 2.1 7.9 7.0 3.4 7.2 4.9 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Nucleoplasmin PF03066.10 EWC43667.1 - 7 6.1 5.9 12 5.3 4.1 1.3 1 0 0 1 1 1 0 Nucleoplasmin Aldo_ket_red PF00248.16 EWC43670.1 - 1.1e-46 158.9 0.0 1.2e-46 158.8 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family PyocinActivator PF11112.3 EWC43672.1 - 0.11 12.4 0.0 0.24 11.2 0.0 1.5 1 0 0 1 1 1 0 Pyocin activator protein PrtN GST_C_3 PF14497.1 EWC43673.1 - 2.7e-08 34.2 0.0 8.8e-08 32.5 0.0 2.0 1 1 1 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 EWC43673.1 - 0.034 14.0 2.3 0.088 12.7 1.5 1.8 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_N PF02798.15 EWC43673.1 - 0.095 12.8 0.0 0.26 11.5 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_C PF00043.20 EWC43673.1 - 0.14 12.1 0.1 0.52 10.3 0.0 1.9 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain MAPEG PF01124.13 EWC43674.1 - 2.5e-21 75.6 2.6 3.1e-21 75.3 1.8 1.1 1 0 0 1 1 1 1 MAPEG family VanZ PF04892.7 EWC43674.1 - 0.079 12.9 0.1 0.14 12.1 0.1 1.4 1 0 0 1 1 1 0 VanZ like family OPT PF03169.10 EWC43675.1 - 1.6e-92 310.9 36.0 1.9e-92 310.7 25.0 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF4064 PF13273.1 EWC43675.1 - 0.18 11.9 0.0 0.18 11.9 0.0 3.9 3 1 1 4 4 4 0 Protein of unknown function (DUF4064) Cellulase PF00150.13 EWC43676.1 - 2.3e-10 40.1 0.0 2.3e-10 40.1 0.0 1.7 2 0 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) Shisa PF13908.1 EWC43676.1 - 0.036 14.2 2.0 0.066 13.3 1.4 1.4 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator MRI PF15325.1 EWC43676.1 - 0.058 14.3 3.2 0.13 13.2 2.2 1.5 1 0 0 1 1 1 0 Modulator of retrovirus infection Abhydrolase_9_N PF15420.1 EWC43676.1 - 0.16 11.6 2.4 0.2 11.3 0.1 2.0 2 0 0 2 2 2 0 Alpha/beta-hydrolase family N-terminus Pneumo_att_G PF05539.6 EWC43676.1 - 0.85 8.9 9.2 1.3 8.3 6.4 1.2 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G SKG6 PF08693.5 EWC43676.1 - 1.2 8.4 8.1 2.8 7.3 5.6 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain F-box-like PF12937.2 EWC43678.1 - 0.0054 16.4 0.0 0.01 15.5 0.0 1.5 1 0 0 1 1 1 1 F-box-like PRANC PF09372.5 EWC43678.1 - 0.18 11.7 0.0 0.37 10.7 0.0 1.4 1 0 0 1 1 1 0 PRANC domain Glyco_hydro_43 PF04616.9 EWC43679.1 - 1.8e-27 96.1 4.1 4e-27 95.0 1.2 2.2 2 1 0 2 2 2 1 Glycosyl hydrolases family 43 F-box-like PF12937.2 EWC43680.1 - 0.0063 16.2 0.1 0.036 13.7 0.0 2.1 2 0 0 2 2 2 1 F-box-like Acyl-CoA_dh_1 PF00441.19 EWC43682.1 - 1.8e-28 99.5 0.0 2.4e-28 99.1 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.14 EWC43682.1 - 5.1e-22 77.1 1.3 1.2e-21 75.9 0.7 1.9 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.11 EWC43682.1 - 6.7e-19 68.5 0.0 1.9e-18 67.1 0.0 1.8 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.6 EWC43682.1 - 0.00014 22.1 0.0 0.00022 21.4 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain MASE2 PF05230.6 EWC43683.1 - 0.26 11.2 0.0 0.63 10.0 0.0 1.6 1 0 0 1 1 1 0 MASE2 domain Acetyltransf_7 PF13508.1 EWC43685.1 - 5.1e-08 32.9 0.0 7.6e-06 26.0 0.0 2.3 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 EWC43685.1 - 1.4e-07 31.4 0.0 7.3e-07 29.1 0.0 2.2 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 EWC43685.1 - 2.2e-05 24.5 0.0 0.04 14.0 0.0 2.3 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 EWC43685.1 - 0.052 13.4 0.0 0.22 11.3 0.0 2.0 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain FR47 PF08445.5 EWC43685.1 - 0.14 11.9 0.0 0.34 10.7 0.0 1.6 1 1 0 1 1 1 0 FR47-like protein Amidohydro_3 PF07969.6 EWC43686.1 - 4.4e-46 157.9 1.7 5.4e-46 157.6 1.2 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_5 PF13594.1 EWC43686.1 - 3e-05 23.7 0.1 7.4e-05 22.4 0.1 1.6 1 0 0 1 1 1 1 Amidohydrolase F-box-like PF12937.2 EWC43688.1 - 2.1e-05 24.1 0.3 6.3e-05 22.6 0.2 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EWC43688.1 - 3e-05 23.5 0.1 6.5e-05 22.4 0.1 1.5 1 0 0 1 1 1 1 F-box domain Tannase PF07519.6 EWC43689.1 - 1.7e-72 244.7 0.5 3e-72 243.8 0.3 1.4 1 0 0 1 1 1 1 Tannase and feruloyl esterase Abhydrolase_6 PF12697.2 EWC43689.1 - 2e-05 24.5 0.0 4.1e-05 23.5 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EWC43689.1 - 0.00011 21.7 0.0 0.001 18.6 0.0 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EWC43689.1 - 0.00065 19.4 0.1 0.0094 15.7 0.1 2.2 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 EWC43689.1 - 0.0022 17.2 2.1 0.27 10.4 0.1 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family F-box-like PF12937.2 EWC43690.1 - 3.1e-09 36.3 0.9 8.8e-05 22.1 0.0 2.3 2 0 0 2 2 2 2 F-box-like F-box PF00646.28 EWC43690.1 - 7e-06 25.5 0.1 0.021 14.4 0.0 2.7 2 1 0 2 2 2 2 F-box domain Nop53 PF07767.6 EWC43690.1 - 0.19 10.7 2.4 0.25 10.2 1.7 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) MR_MLE_C PF13378.1 EWC43691.1 - 2.9e-19 69.0 0.0 8.3e-19 67.5 0.0 1.7 2 0 0 2 2 2 1 Enolase C-terminal domain-like MR_MLE_N PF02746.11 EWC43691.1 - 3.1e-10 40.0 0.0 6.3e-10 39.0 0.0 1.5 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain MR_MLE PF01188.16 EWC43691.1 - 1.2e-08 35.3 0.0 2.7e-08 34.2 0.0 1.5 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain DHDPS PF00701.17 EWC43692.1 - 2e-29 102.1 0.0 2.5e-29 101.7 0.0 1.1 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family Macscav_rec PF03523.8 EWC43692.1 - 0.13 12.0 0.0 0.29 10.9 0.0 1.5 1 0 0 1 1 1 0 Macrophage scavenger receptor DUF4470 PF14737.1 EWC43694.1 - 0.0061 16.2 0.1 0.013 15.2 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4470) Voltage_CLC PF00654.15 EWC43695.1 - 0.0021 17.1 0.3 0.0025 16.8 0.2 1.2 1 0 0 1 1 1 1 Voltage gated chloride channel DctQ PF04290.7 EWC43695.1 - 0.47 10.2 7.2 0.42 10.3 2.8 2.1 2 1 0 2 2 2 0 Tripartite ATP-independent periplasmic transporters, DctQ component Glyco_hydro_15 PF00723.16 EWC43696.1 - 3e-67 227.1 0.0 3.7e-67 226.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 SARA PF11409.3 EWC43698.1 - 1.9 8.4 6.0 1.2 9.0 0.9 2.5 2 0 0 2 2 2 0 Smad anchor for receptor activation (SARA) G-alpha PF00503.15 EWC43699.1 - 8.8e-120 399.9 1.4 1.1e-119 399.6 1.0 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.16 EWC43699.1 - 7.4e-14 51.3 1.7 4.3e-09 35.8 0.1 2.5 2 1 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.7 EWC43699.1 - 0.00015 20.9 5.4 0.024 13.7 0.8 3.1 2 1 0 2 2 2 2 Gtr1/RagA G protein conserved region FtsK_SpoIIIE PF01580.13 EWC43699.1 - 0.0086 15.5 0.0 0.015 14.7 0.0 1.3 1 0 0 1 1 1 1 FtsK/SpoIIIE family GTP_EFTU PF00009.22 EWC43699.1 - 0.017 14.5 0.0 1.1 8.6 0.0 2.2 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_29 PF13555.1 EWC43699.1 - 0.021 14.3 0.0 0.041 13.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Miro PF08477.8 EWC43699.1 - 0.021 15.3 0.0 3.9 7.9 0.0 2.9 2 1 0 2 2 2 0 Miro-like protein DUF676 PF05057.9 EWC43700.1 - 2.2e-53 180.8 0.0 3e-53 180.3 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_6 PF12697.2 EWC43700.1 - 2e-08 34.4 0.0 3.6e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EWC43700.1 - 2.9e-08 33.6 0.0 5.7e-08 32.6 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.8 EWC43700.1 - 4.9e-05 23.0 0.0 9e-05 22.1 0.0 1.4 1 0 0 1 1 1 1 PGAP1-like protein Lipase_3 PF01764.20 EWC43700.1 - 0.0097 15.5 0.0 0.019 14.5 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) Thioesterase PF00975.15 EWC43700.1 - 0.0098 16.1 0.0 0.019 15.2 0.0 1.4 1 0 0 1 1 1 1 Thioesterase domain Homeobox PF00046.24 EWC43701.1 - 2.6e-15 55.7 4.7 9.4e-15 53.9 3.2 2.0 2 0 0 2 2 2 1 Homeobox domain Homeobox_KN PF05920.6 EWC43701.1 - 0.07 12.8 0.5 0.2 11.3 0.3 1.8 1 0 0 1 1 1 0 Homeobox KN domain DUF3115 PF11312.3 EWC43702.1 - 5.6e-52 176.5 0.0 8.7e-52 175.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3115) Amino_oxidase PF01593.19 EWC43703.1 - 3.4e-49 168.1 0.0 2.3e-30 106.0 0.0 2.1 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.1 EWC43703.1 - 1.9e-12 47.0 0.1 4.4e-12 45.8 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 EWC43703.1 - 1e-05 25.6 0.1 7.4e-05 22.8 0.1 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 EWC43703.1 - 2.3e-05 23.4 0.0 0.00018 20.5 0.0 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.9 EWC43703.1 - 2.5e-05 22.9 0.4 4.6e-05 22.0 0.3 1.4 1 0 0 1 1 1 1 HI0933-like protein Thi4 PF01946.12 EWC43703.1 - 4.9e-05 22.5 0.2 9.8e-05 21.5 0.1 1.4 1 0 0 1 1 1 1 Thi4 family Pyr_redox PF00070.22 EWC43703.1 - 5.2e-05 23.5 0.6 0.00012 22.4 0.4 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 EWC43703.1 - 7.2e-05 22.0 0.6 0.00011 21.3 0.4 1.2 1 0 0 1 1 1 1 FAD binding domain AlaDh_PNT_C PF01262.16 EWC43703.1 - 0.00028 20.4 0.2 0.00053 19.5 0.1 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_2 PF00890.19 EWC43703.1 - 0.00057 18.8 1.7 0.00093 18.1 1.2 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_7 PF13241.1 EWC43703.1 - 0.00063 19.9 0.0 0.0011 19.1 0.0 1.4 1 0 0 1 1 1 1 Putative NAD(P)-binding FAD_oxidored PF12831.2 EWC43703.1 - 0.0013 17.8 0.1 0.0021 17.2 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 EWC43703.1 - 0.0045 16.8 0.3 0.0093 15.8 0.2 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.13 EWC43703.1 - 0.0065 16.1 0.4 0.011 15.4 0.3 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Shikimate_DH PF01488.15 EWC43703.1 - 0.014 15.5 0.0 0.025 14.6 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NAD_binding_9 PF13454.1 EWC43703.1 - 0.03 14.1 0.6 0.97 9.1 0.1 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding ThiF PF00899.16 EWC43703.1 - 0.041 13.6 0.6 0.085 12.6 0.4 1.5 1 0 0 1 1 1 0 ThiF family GIDA PF01134.17 EWC43703.1 - 0.043 12.6 1.1 0.059 12.2 0.2 1.6 2 0 0 2 2 2 0 Glucose inhibited division protein A Lycopene_cycl PF05834.7 EWC43703.1 - 0.066 12.1 0.2 3 6.6 0.3 2.1 2 0 0 2 2 2 0 Lycopene cyclase protein 2-Hacid_dh_C PF02826.14 EWC43703.1 - 0.081 12.0 0.0 0.14 11.2 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TrkA_N PF02254.13 EWC43703.1 - 0.14 12.1 0.1 0.27 11.2 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain Band_7 PF01145.20 EWC43704.1 - 4e-24 85.4 4.9 5.4e-24 85.0 3.1 1.5 1 1 0 1 1 1 1 SPFH domain / Band 7 family GatB_Yqey PF02637.13 EWC43704.1 - 0.0019 17.9 1.8 0.0032 17.1 1.3 1.4 1 0 0 1 1 1 1 GatB domain UcrQ PF02939.11 EWC43705.1 - 3.5e-29 100.4 0.0 4.1e-29 100.2 0.0 1.0 1 0 0 1 1 1 1 UcrQ family Ribosomal_L7Ae PF01248.21 EWC43708.1 - 1.7e-25 88.3 0.0 2.2e-25 87.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.6 EWC43708.1 - 0.00014 21.7 0.1 0.00016 21.5 0.0 1.1 1 0 0 1 1 1 1 RNase P subunit Pop3 PELOTA_1 PF15608.1 EWC43708.1 - 0.0093 15.7 0.0 0.013 15.2 0.0 1.3 1 0 0 1 1 1 1 PELOTA RNA binding domain ETC_C1_NDUFA5 PF04716.9 EWC43708.1 - 0.2 11.2 1.0 0.35 10.4 0.0 1.8 2 0 0 2 2 2 0 ETC complex I subunit conserved region ATP-synt_C PF00137.16 EWC43709.1 - 7.6e-30 102.6 29.2 8e-19 67.3 8.4 2.0 2 0 0 2 2 2 2 ATP synthase subunit C DUF2970 PF11174.3 EWC43709.1 - 4.4 6.9 9.1 0.53 9.9 0.4 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2970) Sugar_tr PF00083.19 EWC43710.1 - 1.7e-77 260.9 17.7 2.2e-77 260.5 12.3 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EWC43710.1 - 2.6e-09 36.2 41.6 6.1e-05 21.8 7.0 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily UAA PF08449.6 EWC43710.1 - 0.00066 18.6 0.2 0.0014 17.6 0.1 1.4 1 0 0 1 1 1 1 UAA transporter family Roughex PF06020.6 EWC43711.1 - 0.043 12.4 0.4 0.062 11.9 0.3 1.1 1 0 0 1 1 1 0 Drosophila roughex protein Mito_carr PF00153.22 EWC43715.1 - 3e-53 177.5 0.1 6e-20 70.7 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein RNase_T PF00929.19 EWC43716.1 - 7.8e-13 49.0 0.1 5.1e-05 23.6 0.0 2.7 3 0 0 3 3 3 2 Exonuclease BTK PF00779.14 EWC43716.1 - 0.043 13.4 3.8 0.1 12.2 2.6 1.6 1 0 0 1 1 1 0 BTK motif CHORD PF04968.7 EWC43716.1 - 0.22 11.7 3.1 0.43 10.8 2.1 1.4 1 0 0 1 1 1 0 CHORD Tektin PF03148.9 EWC43717.1 - 0.0082 14.7 5.3 0.014 13.9 3.7 1.3 1 0 0 1 1 1 1 Tektin family DUF651 PF04895.7 EWC43717.1 - 0.066 12.8 2.5 0.072 12.7 0.4 2.1 2 1 0 2 2 2 0 Archaeal protein of unknown function (DUF651) PBP1_TM PF14812.1 EWC43718.1 - 0.091 13.0 2.0 0.12 12.6 1.4 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF3246 PF11596.3 EWC43718.1 - 0.1 11.8 0.9 0.11 11.7 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) Cupin_8 PF13621.1 EWC43722.1 - 2.5e-16 59.9 0.0 3.6e-16 59.4 0.0 1.4 1 1 0 1 1 1 1 Cupin-like domain JmjC PF02373.17 EWC43722.1 - 0.017 15.3 0.0 0.09 13.0 0.0 1.9 2 0 0 2 2 2 0 JmjC domain, hydroxylase Cupin_4 PF08007.7 EWC43722.1 - 0.055 12.7 0.0 0.25 10.5 0.0 1.9 2 0 0 2 2 2 0 Cupin superfamily protein Peptidase_S8 PF00082.17 EWC43724.1 - 3.6e-48 164.1 15.3 5.9e-48 163.4 10.6 1.3 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.11 EWC43724.1 - 2.4e-14 53.6 0.1 7.5e-14 52.0 0.0 1.9 2 0 0 2 2 2 1 Peptidase inhibitor I9 Glyco_hydro_61 PF03443.9 EWC43726.1 - 3.8e-53 180.5 0.0 4.4e-53 180.3 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 Peptidase_S41 PF03572.13 EWC43727.1 - 2.4e-07 30.3 0.0 8.1e-07 28.6 0.0 1.8 1 1 0 1 1 1 1 Peptidase family S41 Y_phosphatase3 PF13350.1 EWC43728.1 - 2.8e-23 82.9 0.0 1.5e-22 80.5 0.0 2.2 1 1 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase2 PF03162.8 EWC43728.1 - 4.7e-06 26.0 0.0 1e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3C PF13348.1 EWC43728.1 - 0.018 15.1 0.1 0.046 13.8 0.0 1.8 2 0 0 2 2 2 0 Tyrosine phosphatase family C-terminal region Y_phosphatase PF00102.22 EWC43728.1 - 0.12 11.7 0.0 0.21 10.8 0.0 1.4 1 0 0 1 1 1 0 Protein-tyrosine phosphatase ABC_membrane PF00664.18 EWC43729.1 - 5.9e-54 183.3 35.5 2.3e-28 99.4 12.6 3.1 3 0 0 3 3 3 3 ABC transporter transmembrane region ABC_tran PF00005.22 EWC43729.1 - 9.7e-52 174.9 0.1 2.6e-29 102.2 0.1 2.8 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 EWC43729.1 - 1.7e-08 34.7 2.0 0.031 14.2 0.0 4.3 4 1 0 4 4 3 2 AAA domain MMR_HSR1 PF01926.18 EWC43729.1 - 1.1e-07 31.8 2.7 0.0076 16.1 0.1 3.8 3 1 0 3 3 3 2 50S ribosome-binding GTPase SMC_N PF02463.14 EWC43729.1 - 4.6e-07 29.2 2.8 0.027 13.7 0.7 3.5 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_22 PF13401.1 EWC43729.1 - 2.6e-05 24.3 0.6 0.086 12.9 0.1 3.1 2 1 0 2 2 2 2 AAA domain AAA_29 PF13555.1 EWC43729.1 - 3.8e-05 23.1 1.1 0.12 11.9 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain Miro PF08477.8 EWC43729.1 - 4.4e-05 23.9 1.2 0.21 12.1 0.0 2.8 2 0 0 2 2 2 2 Miro-like protein DUF258 PF03193.11 EWC43729.1 - 4.8e-05 22.5 1.6 0.15 11.2 0.2 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_16 PF13191.1 EWC43729.1 - 0.00016 21.6 0.3 0.24 11.3 0.0 2.9 2 0 0 2 2 2 2 AAA ATPase domain DUF87 PF01935.12 EWC43729.1 - 0.00026 20.8 2.1 0.095 12.5 0.2 2.6 2 0 0 2 2 2 2 Domain of unknown function DUF87 Zeta_toxin PF06414.7 EWC43729.1 - 0.00032 19.8 0.0 0.066 12.2 0.0 2.3 2 0 0 2 2 2 1 Zeta toxin AAA_10 PF12846.2 EWC43729.1 - 0.001 18.5 0.1 1.1 8.6 0.0 2.5 2 0 0 2 2 2 2 AAA-like domain Dynamin_N PF00350.18 EWC43729.1 - 0.0013 18.5 4.3 0.085 12.6 0.4 2.7 2 1 0 2 2 2 1 Dynamin family FtsK_SpoIIIE PF01580.13 EWC43729.1 - 0.0018 17.7 0.1 1.1 8.7 0.0 2.5 2 0 0 2 2 2 2 FtsK/SpoIIIE family AAA_25 PF13481.1 EWC43729.1 - 0.0038 16.6 0.0 0.22 10.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.1 EWC43729.1 - 0.005 17.1 0.2 2.2 8.5 0.1 2.5 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 EWC43729.1 - 0.0058 17.4 2.7 3.7 8.4 0.5 2.7 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.17 EWC43729.1 - 0.012 15.8 0.1 3 8.0 0.0 3.2 2 0 0 2 2 2 0 RNA helicase T2SE PF00437.15 EWC43729.1 - 0.063 12.1 0.6 0.59 8.9 0.0 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_30 PF13604.1 EWC43729.1 - 0.092 12.3 2.1 7.8 6.0 0.0 2.8 3 0 0 3 3 3 0 AAA domain TrwB_AAD_bind PF10412.4 EWC43729.1 - 0.12 11.0 1.1 1.7 7.1 0.0 2.3 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain MobB PF03205.9 EWC43729.1 - 0.13 11.9 1.7 3.4 7.3 0.1 2.8 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_18 PF13238.1 EWC43729.1 - 0.16 12.2 1.7 13 6.1 0.1 2.5 2 0 0 2 2 2 0 AAA domain Mnd1 PF03962.10 EWC43730.1 - 6.6e-11 42.2 0.1 7.1e-11 42.1 0.0 1.0 1 0 0 1 1 1 1 Mnd1 family Arrestin_N PF00339.24 EWC43731.1 - 5.4e-12 45.7 0.0 1.7e-11 44.1 0.0 1.9 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.17 EWC43731.1 - 0.00052 20.1 0.0 0.068 13.2 0.0 2.5 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Fungal_trans PF04082.13 EWC43735.1 - 1e-25 90.0 2.6 2e-25 89.1 1.8 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF2605 PF10792.4 EWC43736.1 - 0.088 12.4 0.1 0.18 11.4 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2605) 2OG-FeII_Oxy_3 PF13640.1 EWC43736.1 - 0.14 12.7 0.0 0.3 11.6 0.0 1.5 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily BNR PF02012.15 EWC43739.1 - 2.6e-05 23.3 3.8 0.11 12.4 0.1 3.3 3 0 0 3 3 3 2 BNR/Asp-box repeat BNR_2 PF13088.1 EWC43739.1 - 5.7e-05 22.5 0.3 0.017 14.4 0.1 2.3 1 1 1 2 2 2 2 BNR repeat-like domain DUF4185 PF13810.1 EWC43739.1 - 0.039 12.8 0.1 5.4 5.8 0.0 2.7 4 0 0 4 4 4 0 Domain of unknown function (DUF4185) DIE2_ALG10 PF04922.7 EWC43740.1 - 0.0078 15.2 0.3 0.0094 15.0 0.2 1.1 1 0 0 1 1 1 1 DIE2/ALG10 family zf-CCCH PF00642.19 EWC43741.1 - 7.9e-05 22.2 1.7 0.00019 21.0 1.2 1.7 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) GDH_N PF12466.3 EWC43741.1 - 0.19 11.7 0.5 0.37 10.8 0.4 1.5 1 0 0 1 1 1 0 Glutamate dehydrogenase N terminal DUF402 PF04167.8 EWC43744.1 - 0.27 11.0 2.4 7.4 6.4 1.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF402) zf-C3HC4_3 PF13920.1 EWC43745.1 - 3.4e-12 45.8 3.5 5.4e-12 45.1 2.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 EWC43745.1 - 1.3e-05 25.1 5.2 4.4e-05 23.4 2.8 2.1 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EWC43745.1 - 2.3e-05 24.0 2.0 3.8e-05 23.3 1.4 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.1 EWC43745.1 - 0.00015 21.5 4.1 0.00025 20.7 2.8 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 EWC43745.1 - 0.0015 18.1 1.8 0.0032 17.1 0.9 1.8 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.1 EWC43745.1 - 0.35 10.4 4.8 9.1 5.9 0.1 2.4 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 Paramyxo_NS_C PF02725.9 EWC43746.1 - 1.6 8.2 5.9 0.99 9.0 0.1 2.3 2 1 0 2 2 2 0 Non-structural protein C NUDIX PF00293.23 EWC43748.1 - 3.2e-06 26.8 0.1 8.3e-06 25.4 0.1 1.7 1 1 0 1 1 1 1 NUDIX domain Ribonuclease_T2 PF00445.13 EWC43749.1 - 1.1e-41 142.5 4.1 1.1e-41 142.5 2.8 1.5 2 0 0 2 2 2 1 Ribonuclease T2 family EamA PF00892.15 EWC43751.1 - 1.2e-10 41.4 24.8 2.9e-06 27.3 1.1 2.5 2 0 0 2 2 2 2 EamA-like transporter family EmrE PF13536.1 EWC43751.1 - 9.8e-07 28.9 2.7 9.8e-07 28.9 1.9 3.4 2 1 1 3 3 3 1 Multidrug resistance efflux transporter UPF0546 PF10639.4 EWC43751.1 - 0.029 14.1 1.1 0.029 14.1 0.7 2.3 2 0 0 2 2 2 0 Uncharacterised protein family UPF0546 CD99L2 PF12301.3 EWC43751.1 - 0.089 12.4 0.7 0.14 11.8 0.5 1.2 1 0 0 1 1 1 0 CD99 antigen like protein 2 TPT PF03151.11 EWC43751.1 - 0.11 12.1 18.4 0.063 12.9 1.3 2.6 2 1 0 2 2 2 0 Triose-phosphate Transporter family PgaD PF13994.1 EWC43751.1 - 4.6 6.7 8.7 0.17 11.3 0.7 2.5 3 0 0 3 3 3 0 PgaD-like protein HATPase_c PF02518.21 EWC43752.1 - 3.3e-27 94.4 0.0 1e-26 92.8 0.0 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.19 EWC43752.1 - 7.2e-26 90.3 1.0 1.3e-25 89.5 0.7 1.5 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.20 EWC43752.1 - 2.2e-13 49.9 0.0 7.5e-13 48.2 0.0 2.0 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain Zn_clus PF00172.13 EWC43752.1 - 7.2e-08 32.2 8.8 1.2e-07 31.4 6.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 EWC43752.1 - 2.2e-05 23.4 0.0 3.6e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain HAMP PF00672.20 EWC43752.1 - 0.00014 21.9 8.5 0.00076 19.6 0.3 3.9 3 1 0 3 3 3 1 HAMP domain Fungal_trans PF04082.13 EWC43753.1 - 1.4e-15 56.8 0.0 2.3e-15 56.2 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EWC43753.1 - 4.6e-09 36.0 7.1 8.4e-09 35.2 4.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2439 PF10382.4 EWC43756.1 - 1.3e-21 76.6 0.8 2.1e-21 75.8 0.5 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2439) MFS_1 PF07690.11 EWC43757.1 - 1.3e-44 152.3 49.2 3e-44 151.1 34.1 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.8 EWC43757.1 - 2.3e-13 49.2 19.6 3e-13 48.8 13.6 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.19 EWC43757.1 - 1.9e-07 30.0 13.1 1.9e-07 30.0 9.1 3.5 3 1 1 4 4 4 2 Sugar (and other) transporter TauD PF02668.11 EWC43759.1 - 7.4e-28 97.9 0.0 9.6e-28 97.5 0.0 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family CsiD PF08943.5 EWC43759.1 - 0.073 11.9 0.0 0.13 11.0 0.0 1.3 1 0 0 1 1 1 0 CsiD ETF PF01012.16 EWC43760.1 - 6.3e-36 123.5 0.4 8.3e-36 123.1 0.2 1.1 1 0 0 1 1 1 1 Electron transfer flavoprotein domain EF-hand_1 PF00036.27 EWC43761.1 - 7.8e-37 121.7 15.9 2.5e-10 38.8 1.2 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 EWC43761.1 - 1.5e-30 105.0 11.9 2.6e-17 62.7 1.4 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 EWC43761.1 - 9.8e-30 99.7 12.9 6e-10 38.1 0.1 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.1 EWC43761.1 - 2.4e-24 84.6 16.7 3.1e-13 49.1 0.8 4.1 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.1 EWC43761.1 - 3.9e-21 73.3 19.3 7.4e-07 28.2 0.1 4.7 4 2 0 4 4 4 3 EF hand EF-hand_9 PF14658.1 EWC43761.1 - 1.4e-17 63.3 0.4 2.6e-08 33.6 0.1 2.1 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.4 EWC43761.1 - 2.5e-07 30.7 1.5 0.0027 17.6 0.0 2.1 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 EWC43761.1 - 6e-07 29.1 4.8 0.0055 16.4 0.4 2.4 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand UPF0154 PF03672.8 EWC43761.1 - 0.00017 21.1 0.0 0.19 11.3 0.0 2.2 2 0 0 2 2 2 2 Uncharacterised protein family (UPF0154) TerB PF05099.8 EWC43761.1 - 0.0016 18.1 4.0 0.86 9.3 0.1 2.9 1 1 0 2 2 2 2 Tellurite resistance protein TerB EF-hand_10 PF14788.1 EWC43761.1 - 0.021 14.4 7.9 0.17 11.5 0.1 4.1 2 2 3 5 5 5 0 EF hand TRCF PF03461.10 EWC43761.1 - 0.022 14.7 0.4 0.063 13.2 0.1 1.9 1 1 1 2 2 2 0 TRCF domain DUF1456 PF07308.8 EWC43761.1 - 0.049 13.6 1.1 1.4 9.0 0.2 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1456) Caleosin PF05042.8 EWC43761.1 - 0.051 13.1 0.1 5.2 6.5 0.0 2.3 2 0 0 2 2 2 0 Caleosin related protein DUF3879 PF12995.2 EWC43761.1 - 0.083 12.4 0.0 0.4 10.2 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function, E. rectale Gene description (DUF3879) TBPIP PF07106.8 EWC43761.1 - 0.084 12.4 0.2 2.1 7.8 0.0 2.2 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) SapB_1 PF05184.10 EWC43761.1 - 0.11 12.3 0.0 14 5.6 0.0 2.5 2 0 0 2 2 2 0 Saposin-like type B, region 1 Fer2_BFD PF04324.10 EWC43761.1 - 0.14 12.2 0.9 1.8 8.6 0.0 2.6 4 0 0 4 4 3 0 BFD-like [2Fe-2S] binding domain EF-hand_2 PF09068.6 EWC43761.1 - 0.15 12.1 0.1 0.41 10.7 0.0 1.8 2 1 0 2 2 1 0 EF hand DUF1801 PF08818.6 EWC43761.1 - 0.15 12.1 0.1 23 5.1 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DU1801) RNA_pol_Rpb4 PF03874.11 EWC43761.1 - 0.31 11.0 2.9 13 5.8 0.2 2.5 2 1 0 2 2 2 0 RNA polymerase Rpb4 Toprim_2 PF13155.1 EWC43761.1 - 0.45 10.8 2.7 20 5.5 0.0 2.4 2 1 0 2 2 2 0 Toprim-like SAP PF02037.22 EWC43762.1 - 6e-12 44.7 2.8 1e-11 44.0 1.9 1.4 1 0 0 1 1 1 1 SAP domain Telomere_Sde2_2 PF13297.1 EWC43762.1 - 0.078 12.2 0.8 0.16 11.2 0.5 1.4 1 0 0 1 1 1 0 Telomere stability C-terminal DUF3951 PF13131.1 EWC43762.1 - 0.32 10.7 0.1 0.58 9.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3951) Apolipoprotein PF01442.13 EWC43763.1 - 0.0059 16.1 2.7 0.011 15.2 1.9 1.4 1 1 0 1 1 1 1 Apolipoprotein A1/A4/E domain LPP PF04728.8 EWC43763.1 - 0.12 12.2 1.4 0.2 11.4 1.0 1.5 1 0 0 1 1 1 0 Lipoprotein leucine-zipper DUF1664 PF07889.7 EWC43763.1 - 0.13 12.1 1.0 0.17 11.6 0.5 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) ISG65-75 PF11727.3 EWC43763.1 - 0.14 11.2 9.1 0.17 10.9 6.3 1.1 1 0 0 1 1 1 0 Invariant surface glycoprotein YscO PF07321.7 EWC43763.1 - 0.21 11.3 1.6 0.29 10.9 1.1 1.2 1 0 0 1 1 1 0 Type III secretion protein YscO DUF3708 PF12501.3 EWC43763.1 - 0.32 10.8 2.4 0.36 10.6 1.6 1.2 1 0 0 1 1 1 0 Phosphate ATP-binding cassette transporter DUF883 PF05957.8 EWC43763.1 - 0.33 11.3 6.6 4 7.8 0.8 2.2 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) MCP_N PF05581.7 EWC43763.1 - 0.38 10.9 2.6 0.87 9.7 0.6 2.0 1 1 1 2 2 2 0 Vibrio chemotaxis protein N terminus CsbD PF05532.7 EWC43763.1 - 0.73 9.5 18.0 0.27 10.9 1.3 4.2 2 2 2 4 4 4 0 CsbD-like DDHD PF02862.12 EWC43763.1 - 0.93 9.2 4.4 1.1 8.9 3.0 1.1 1 0 0 1 1 1 0 DDHD domain SRP-alpha_N PF04086.8 EWC43763.1 - 1.3 8.3 9.4 1.6 8.0 6.5 1.0 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal ORF6C PF10552.4 EWC43763.1 - 1.9 8.2 6.4 2.2 8.0 0.3 2.6 1 1 2 3 3 3 0 ORF6C domain YtxH PF12732.2 EWC43763.1 - 2.4 8.6 12.5 6e+02 0.8 8.7 2.7 1 1 0 1 1 1 0 YtxH-like protein DUF3359 PF11839.3 EWC43763.1 - 6.2 7.2 11.2 4.1 7.8 5.9 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3359) DivIVA PF05103.8 EWC43763.1 - 6.5 6.8 10.1 15 5.6 7.0 1.7 1 1 0 1 1 1 0 DivIVA protein CPSase_sm_chain PF00988.17 EWC43765.1 - 5.9e-44 148.7 0.0 1e-43 147.9 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.23 EWC43765.1 - 8e-44 149.3 0.0 1.1e-43 148.9 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 EWC43765.1 - 0.00015 21.3 0.2 0.015 14.7 0.1 2.3 1 1 0 1 1 1 1 Peptidase C26 Nitroreductase PF00881.19 EWC43766.1 - 2.7e-12 46.8 0.0 3.3e-12 46.5 0.0 1.1 1 0 0 1 1 1 1 Nitroreductase family Epimerase PF01370.16 EWC43767.1 - 1.1e-30 106.8 0.0 2.1e-30 105.9 0.0 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.7 EWC43767.1 - 3.6e-09 35.9 0.0 6.1e-09 35.1 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein Epimerase_Csub PF13950.1 EWC43767.1 - 4.2e-09 36.2 0.1 1.2e-08 34.7 0.1 1.8 1 0 0 1 1 1 1 UDP-glucose 4-epimerase C-term subunit 3Beta_HSD PF01073.14 EWC43767.1 - 6.1e-07 28.4 0.0 1.5e-06 27.1 0.0 1.7 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.10 EWC43767.1 - 8.7e-06 24.8 0.0 2.7e-05 23.2 0.0 1.7 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein adh_short PF00106.20 EWC43767.1 - 2.9e-05 24.0 0.0 8.8e-05 22.4 0.0 1.8 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EWC43767.1 - 0.0043 16.7 0.0 0.0085 15.7 0.0 1.5 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 EWC43767.1 - 0.014 15.4 2.4 0.39 10.6 0.1 3.1 2 1 0 2 2 2 0 NADH(P)-binding IF2_N PF04760.10 EWC43767.1 - 0.14 11.8 0.0 0.48 10.1 0.0 1.9 2 0 0 2 2 2 0 Translation initiation factor IF-2, N-terminal region RgpF PF05045.7 EWC43768.1 - 0.04 12.4 0.1 0.23 9.9 0.0 1.9 1 1 0 1 1 1 0 Rhamnan synthesis protein F gp45-slide_C PF09116.5 EWC43768.1 - 0.17 11.9 0.2 1.5 8.7 0.0 2.2 1 1 1 2 2 2 0 gp45 sliding clamp, C terminal Fig1 PF12351.3 EWC43769.1 - 0.02 14.7 4.5 0.84 9.4 1.6 2.2 2 0 0 2 2 2 0 Ca2+ regulator and membrane fusion protein Fig1 Ammonium_transp PF00909.16 EWC43770.1 - 1.8e-110 369.1 27.5 2e-110 368.9 19.1 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family DUF2304 PF10066.4 EWC43770.1 - 0.41 10.5 2.9 0.27 11.0 0.1 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2304) BTB PF00651.26 EWC43774.1 - 4.6e-09 36.2 0.1 2.5e-06 27.4 0.0 2.3 2 0 0 2 2 2 2 BTB/POZ domain DUF4535 PF15054.1 EWC43774.1 - 0.043 13.2 0.0 0.085 12.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4535) MFS_1 PF07690.11 EWC43776.1 - 8.8e-29 100.3 80.8 2.2e-25 89.1 33.5 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EWC43776.1 - 1.9e-05 23.4 46.7 0.012 14.2 12.0 3.8 1 1 3 4 4 4 3 Sugar (and other) transporter DUF202 PF02656.10 EWC43776.1 - 0.051 13.7 1.1 0.051 13.7 0.7 4.6 3 2 0 3 3 3 0 Domain of unknown function (DUF202) ATP1G1_PLM_MAT8 PF02038.11 EWC43776.1 - 0.75 8.8 3.3 8.9 5.4 0.1 2.9 2 0 0 2 2 2 0 ATP1G1/PLM/MAT8 family FAD_binding_4 PF01565.18 EWC43778.1 - 1.1e-25 89.7 1.2 2e-25 88.8 0.8 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.7 EWC43778.1 - 9.2e-14 51.0 0.7 1.8e-13 50.1 0.5 1.5 1 0 0 1 1 1 1 Berberine and berberine like WSC PF01822.14 EWC43779.1 - 2.4e-33 113.9 25.0 4e-19 68.3 5.5 5.8 5 1 0 6 6 6 2 WSC domain Med3 PF11593.3 EWC43779.1 - 2.6 7.1 20.1 3.7 6.6 14.0 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DUF1399 PF07173.7 EWC43780.1 - 7.7e-23 81.2 0.4 6.7e-19 68.5 0.0 2.7 2 0 0 2 2 2 2 Protein of unknown function (DUF1399) DUF2183 PF09949.4 EWC43781.1 - 3e-25 88.0 0.0 1.1e-24 86.2 0.0 1.8 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2183) C2 PF00168.25 EWC43783.1 - 7.2e-06 25.7 0.0 1.3e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 C2 domain 4HBT_3 PF13622.1 EWC43784.1 - 4e-45 154.5 0.1 4.6e-45 154.3 0.0 1.0 1 0 0 1 1 1 1 Thioesterase-like superfamily TauD PF02668.11 EWC43785.1 - 2.6e-08 33.8 0.0 1.4e-07 31.4 0.0 2.0 1 1 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family CP_ATPgrasp_2 PF14403.1 EWC43785.1 - 0.00099 17.8 0.0 0.34 9.4 0.0 2.2 2 0 0 2 2 2 2 Circularly permuted ATP-grasp type 2 TTL PF03133.10 EWC43785.1 - 0.21 10.4 0.0 0.41 9.5 0.0 1.4 1 0 0 1 1 1 0 Tubulin-tyrosine ligase family Metallophos PF00149.23 EWC43786.1 - 7.6e-08 31.9 0.1 1.2e-07 31.3 0.1 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 EWC43786.1 - 0.004 17.0 0.0 0.0044 16.8 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Retinin_C PF04527.7 EWC43786.1 - 0.11 12.4 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 Drosophila Retinin like protein polyprenyl_synt PF00348.12 EWC43790.1 - 2.4e-76 256.0 0.0 2.9e-76 255.7 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase Cnd3 PF12719.2 EWC43791.1 - 5.3e-97 324.4 1.5 9.5e-97 323.5 1.1 1.4 1 0 0 1 1 1 1 Nuclear condensing complex subunits, C-term domain HEAT PF02985.17 EWC43791.1 - 0.00023 20.9 0.9 27 5.2 0.0 5.4 5 0 0 5 5 5 2 HEAT repeat HEAT_2 PF13646.1 EWC43791.1 - 0.0059 16.8 14.7 0.0088 16.3 0.2 4.9 4 1 1 5 5 5 2 HEAT repeats GATase_5 PF13507.1 EWC43792.1 - 2.6e-98 328.0 0.0 3.7e-98 327.5 0.0 1.2 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain AIRS_C PF02769.17 EWC43792.1 - 2.4e-44 151.0 0.6 1.9e-22 79.8 0.2 2.4 2 0 0 2 2 2 2 AIR synthase related protein, C-terminal domain AIRS PF00586.19 EWC43792.1 - 6e-26 90.5 0.2 7.1e-25 87.0 0.0 2.5 2 0 0 2 2 2 1 AIR synthase related protein, N-terminal domain PALP PF00291.20 EWC43793.1 - 2.9e-62 210.6 0.1 3.6e-62 210.3 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Telomere_Sde2_2 PF13297.1 EWC43793.1 - 0.09 12.0 0.9 20 4.5 0.0 3.3 3 0 0 3 3 3 0 Telomere stability C-terminal RRM_1 PF00076.17 EWC43795.1 - 1.8e-17 62.7 0.0 1.5e-08 34.1 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EWC43795.1 - 1.5e-12 47.2 0.0 1.7e-06 27.9 0.0 2.6 3 0 0 3 3 3 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EWC43795.1 - 5.5e-09 35.7 0.0 0.0011 18.7 0.0 2.5 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GalKase_gal_bdg PF10509.4 EWC43796.1 - 5.3e-19 67.2 0.0 1e-18 66.3 0.0 1.5 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_N PF00288.21 EWC43796.1 - 1.6e-17 63.2 1.3 4.3e-17 61.9 0.9 1.8 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.8 EWC43796.1 - 6.4e-15 55.1 0.0 1.6e-14 53.8 0.0 1.7 1 0 0 1 1 1 1 GHMP kinases C terminal TPP_enzyme_N PF02776.13 EWC43797.1 - 3.5e-56 189.3 0.1 2e-55 186.9 0.0 2.1 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.16 EWC43797.1 - 1.4e-50 170.8 0.6 1.5e-48 164.2 0.1 3.1 3 0 0 3 3 3 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.17 EWC43797.1 - 1.5e-40 138.1 0.4 2.7e-39 134.0 0.2 2.8 3 0 0 3 3 3 1 Thiamine pyrophosphate enzyme, central domain ATP_sub_h PF10775.4 EWC43798.1 - 1.9e-24 85.1 0.4 2.6e-24 84.6 0.3 1.2 1 0 0 1 1 1 1 ATP synthase complex subunit h ATP-synt_F6 PF05511.6 EWC43798.1 - 0.047 13.5 0.1 0.1 12.5 0.0 1.6 2 0 0 2 2 2 0 Mitochondrial ATP synthase coupling factor 6 TFIIB PF00382.14 EWC43799.1 - 3.3e-37 126.1 0.5 3.9e-20 71.4 0.0 2.4 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.7 EWC43799.1 - 2.3e-12 46.0 1.8 2.3e-12 46.0 1.2 1.8 2 0 0 2 2 2 1 TFIIB zinc-binding TrmB PF01978.14 EWC43799.1 - 0.0053 16.4 0.0 1.8 8.3 0.0 2.6 2 0 0 2 2 2 2 Sugar-specific transcriptional regulator TrmB SRPRB PF09439.5 EWC43799.1 - 0.0077 15.4 0.1 0.013 14.7 0.1 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Cyclin_N PF00134.18 EWC43799.1 - 0.011 15.3 0.2 2.4 7.7 0.0 2.2 1 1 0 2 2 2 0 Cyclin, N-terminal domain HTH_5 PF01022.15 EWC43799.1 - 0.027 14.1 0.0 1.9 8.1 0.0 2.5 2 0 0 2 2 2 0 Bacterial regulatory protein, arsR family Cyclin_C PF02984.14 EWC43799.1 - 0.04 13.8 0.0 1 9.2 0.0 2.3 2 1 0 2 2 2 0 Cyclin, C-terminal domain FANCL_C PF11793.3 EWC43801.1 - 1e-07 31.7 5.1 1.7e-07 31.0 3.6 1.3 1 0 0 1 1 1 1 FANCL C-terminal domain RINGv PF12906.2 EWC43801.1 - 4.9e-06 26.4 7.4 8.3e-06 25.7 5.1 1.4 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.1 EWC43801.1 - 0.0031 17.3 4.9 0.0054 16.5 3.4 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.1 EWC43801.1 - 0.0082 15.7 2.6 0.04 13.5 2.1 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) FxsA PF04186.8 EWC43801.1 - 0.094 12.3 0.3 0.24 10.9 0.2 1.6 1 0 0 1 1 1 0 FxsA cytoplasmic membrane protein zf-C3HC4 PF00097.20 EWC43801.1 - 2 8.1 5.1 3.4 7.4 3.5 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Pkinase PF00069.20 EWC43802.1 - 2.2e-58 197.4 0.0 2.9e-58 197.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC43802.1 - 1.3e-31 109.6 0.0 1.6e-31 109.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 EWC43802.1 - 4.2e-05 23.3 0.0 9e-05 22.3 0.0 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.1 EWC43802.1 - 0.00025 20.1 0.0 0.0015 17.5 0.0 2.0 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.9 EWC43802.1 - 0.079 12.0 0.0 0.11 11.4 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.4 EWC43802.1 - 0.12 11.7 0.0 0.2 10.9 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Choline_kinase PF01633.15 EWC43802.1 - 0.12 11.8 0.0 0.2 11.2 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase Pkinase PF00069.20 EWC43803.1 - 4.6e-51 173.4 0.0 6.6e-51 172.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC43803.1 - 5e-22 78.2 0.0 1.1e-21 77.1 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.6 EWC43803.1 - 0.0074 15.1 0.1 0.013 14.3 0.1 1.3 1 0 0 1 1 1 1 Poxvirus serine/threonine protein kinase PRP38_assoc PF12871.2 EWC43803.1 - 0.013 16.0 30.6 0.013 16.0 21.2 4.7 5 0 0 5 5 5 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term HlyIII PF03006.15 EWC43804.1 - 7.3e-60 202.1 13.2 8.5e-60 201.9 9.2 1.0 1 0 0 1 1 1 1 Haemolysin-III related DUF4149 PF13664.1 EWC43804.1 - 1.1 9.3 6.6 1.2 9.2 1.0 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4149) DASH_Duo1 PF08651.5 EWC43806.1 - 6.6e-13 48.0 0.1 9.8e-13 47.4 0.1 1.2 1 0 0 1 1 1 1 DASH complex subunit Duo1 Laminin_II PF06009.7 EWC43806.1 - 0.018 14.8 0.8 0.026 14.3 0.6 1.1 1 0 0 1 1 1 0 Laminin Domain II SAC3_GANP PF03399.11 EWC43807.1 - 6e-07 29.2 0.1 8.3e-07 28.7 0.0 1.1 1 0 0 1 1 1 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family Pescadillo_N PF06732.6 EWC43809.1 - 4.3e-117 390.3 0.5 4.3e-117 390.3 0.4 2.2 2 1 0 2 2 2 1 Pescadillo N-terminus BRCT PF00533.21 EWC43809.1 - 6.8e-08 32.5 0.0 2.2e-07 30.9 0.0 2.0 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain WD40 PF00400.27 EWC43810.1 - 0.0027 17.5 1.3 1.2 9.1 0.1 4.6 5 0 0 5 5 5 1 WD domain, G-beta repeat Glycos_transf_2 PF00535.21 EWC43811.1 - 9.3e-33 113.2 0.0 1.1e-32 113.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 EWC43811.1 - 5.4e-14 52.5 0.0 1e-13 51.6 0.0 1.3 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.4 EWC43811.1 - 5e-08 32.3 0.0 6.6e-08 31.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.1 EWC43811.1 - 9.6e-05 21.7 0.0 0.00015 21.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_4 PF13704.1 EWC43811.1 - 0.038 14.3 0.0 0.07 13.4 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase family 2 Peptidase_M24 PF00557.19 EWC43813.1 - 2.9e-43 147.8 0.0 3.6e-43 147.5 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 zf-MYND PF01753.13 EWC43813.1 - 7.7e-05 22.4 9.0 0.0001 22.1 4.0 2.4 2 0 0 2 2 2 1 MYND finger Aminotran_1_2 PF00155.16 EWC43814.1 - 1.3e-39 136.1 0.0 1.7e-39 135.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 EWC43814.1 - 0.0016 17.6 0.0 0.0022 17.1 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase tRNA-synt_1 PF00133.17 EWC43816.1 - 1.1e-158 529.0 0.0 1.5e-158 528.5 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.8 EWC43816.1 - 4.9e-24 84.8 0.7 9.9e-24 83.8 0.5 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.6 EWC43816.1 - 2.4e-18 65.9 0.2 1.1e-09 37.4 0.0 4.3 3 1 0 3 3 3 3 tRNA synthetases class I (M) zf-FPG_IleRS PF06827.9 EWC43816.1 - 6.3e-06 25.6 5.0 1.3e-05 24.7 3.4 1.6 1 0 0 1 1 1 1 Zinc finger found in FPG and IleRS tRNA-synt_1e PF01406.14 EWC43816.1 - 0.002 17.3 0.0 0.067 12.2 0.0 2.2 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1_2 PF13603.1 EWC43816.1 - 0.0067 15.7 0.0 0.014 14.7 0.0 1.4 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1f PF01921.13 EWC43816.1 - 0.045 12.4 0.0 0.075 11.6 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (K) Ribosomal_L36 PF00444.13 EWC43817.1 - 5e-19 67.9 8.0 7.6e-19 67.4 5.5 1.3 1 0 0 1 1 1 1 Ribosomal protein L36 DUF3123 PF11321.3 EWC43817.1 - 4.4 7.6 8.8 5.4 7.3 5.7 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3123) Syja_N PF02383.13 EWC43818.1 - 4.2e-90 301.7 0.4 5.2e-90 301.4 0.3 1.1 1 0 0 1 1 1 1 SacI homology domain PIG-U PF06728.8 EWC43819.1 - 1.5e-119 399.3 35.4 1.7e-119 399.1 24.6 1.0 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U Acetyltransf_1 PF00583.19 EWC43820.1 - 7.8e-14 51.4 0.0 1.6e-13 50.4 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 EWC43820.1 - 0.00031 20.8 0.1 0.00049 20.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 EWC43820.1 - 0.0029 17.6 0.0 0.005 16.9 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 EWC43820.1 - 0.0042 17.0 0.0 0.0068 16.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 EWC43820.1 - 0.0057 16.3 0.0 0.011 15.4 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.1 EWC43820.1 - 0.01 15.9 0.0 0.015 15.4 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Complex1_LYR PF05347.10 EWC43821.1 - 1.5e-14 53.5 0.1 2.4e-14 52.8 0.0 1.3 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 EWC43821.1 - 1.9e-14 53.6 0.3 3.2e-14 52.8 0.0 1.5 2 0 0 2 2 2 1 Complex1_LYR-like GNAT_acetyltran PF12746.2 EWC43821.1 - 0.11 11.3 0.0 0.13 11.0 0.0 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase SDA1 PF05285.7 EWC43823.1 - 0.13 11.5 4.6 0.71 9.0 0.0 2.2 2 0 0 2 2 2 0 SDA1 Sugar_tr PF00083.19 EWC43824.1 - 2.1e-96 323.2 23.2 2.5e-96 323.0 16.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EWC43824.1 - 1.3e-22 79.9 32.9 4.6e-16 58.4 10.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 EWC43824.1 - 3.7e-05 22.3 22.5 0.00039 18.9 1.5 3.3 2 2 2 4 4 4 2 MFS/sugar transport protein OATP PF03137.15 EWC43824.1 - 0.025 12.6 5.7 0.016 13.2 0.7 2.4 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family DUF3040 PF11239.3 EWC43824.1 - 2.9 7.9 6.3 5.9 7.0 0.4 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) MARVEL PF01284.18 EWC43826.1 - 5.7e-07 29.4 25.3 7.1e-06 25.8 17.5 2.0 1 1 1 2 2 2 2 Membrane-associating domain DUF4328 PF14219.1 EWC43826.1 - 0.097 11.9 0.3 0.097 11.9 0.2 2.3 1 1 2 3 3 3 0 Domain of unknown function (DUF4328) Fig1 PF12351.3 EWC43826.1 - 1.5 8.6 7.5 17 5.2 0.0 2.2 2 0 0 2 2 2 0 Ca2+ regulator and membrane fusion protein Fig1 SOG2 PF10428.4 EWC43827.1 - 6.5 5.2 17.1 9.1 4.8 11.8 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein Peptidase_M20 PF01546.23 EWC43828.1 - 2.1e-27 95.8 4.0 3.7e-27 95.0 2.8 1.4 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 EWC43828.1 - 1.8e-08 34.0 0.1 4.4e-08 32.8 0.0 1.7 1 1 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.12 EWC43828.1 - 1.6e-07 31.2 0.0 1e-06 28.6 0.0 2.2 2 1 0 2 2 2 1 Peptidase family M28 Peptidase_M42 PF05343.9 EWC43828.1 - 0.047 12.4 0.0 0.18 10.5 0.0 1.8 2 0 0 2 2 2 0 M42 glutamyl aminopeptidase Glyco_hydro_10 PF00331.15 EWC43829.1 - 3e-102 341.9 2.5 3.7e-102 341.6 1.7 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 CBM_1 PF00734.13 EWC43829.1 - 6.2e-12 44.9 8.0 6.2e-12 44.9 5.5 2.2 2 0 0 2 2 2 1 Fungal cellulose binding domain Cellulase-like PF12876.2 EWC43829.1 - 0.0011 19.3 0.1 1.1 9.7 0.0 3.0 1 1 1 2 2 2 2 Sugar-binding cellulase-like Dicty_REP PF05086.7 EWC43829.1 - 0.0013 16.6 4.2 0.0021 15.9 2.9 1.3 1 0 0 1 1 1 1 Dictyostelium (Slime Mold) REP protein Fungal_trans PF04082.13 EWC43830.1 - 2.6e-09 36.3 0.1 4.9e-09 35.4 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EWC43830.1 - 4.4e-07 29.7 11.2 6.8e-07 29.0 7.8 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain 1-cysPrx_C PF10417.4 EWC43831.1 - 0.00053 19.5 0.0 0.0015 18.1 0.0 1.8 2 0 0 2 2 2 1 C-terminal domain of 1-Cys peroxiredoxin AhpC-TSA PF00578.16 EWC43831.1 - 0.00058 19.5 0.0 0.0011 18.6 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family ASFV_J13L PF05568.6 EWC43833.1 - 2.4 7.6 4.9 1.4 8.4 1.9 1.7 1 1 1 2 2 2 0 African swine fever virus J13L protein Tyrosinase PF00264.15 EWC43835.1 - 3.6e-42 145.0 0.3 4.8e-42 144.6 0.2 1.1 1 0 0 1 1 1 1 Common central domain of tyrosinase DUF1034 PF06280.7 EWC43836.1 - 0.019 15.3 2.7 0.14 12.5 0.0 2.6 2 0 0 2 2 2 0 Fn3-like domain (DUF1034) HSDR_N_2 PF13588.1 EWC43837.1 - 2.7e-06 27.1 0.0 3.6e-06 26.7 0.0 1.1 1 0 0 1 1 1 1 Type I restriction enzyme R protein N terminus (HSDR_N) CFEM PF05730.6 EWC43840.1 - 0.055 13.3 12.4 0.034 13.9 3.7 2.6 2 0 0 2 2 2 0 CFEM domain HrpB7 PF09486.5 EWC43840.1 - 0.062 13.2 1.5 0.1 12.5 1.0 1.3 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) Pyr_redox_3 PF13738.1 EWC43841.1 - 1.6e-22 80.5 0.0 5.5e-21 75.5 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.14 EWC43841.1 - 1.4e-10 40.0 0.0 9.4e-07 27.3 0.0 3.1 3 0 0 3 3 3 2 Flavin-binding monooxygenase-like NAD_binding_9 PF13454.1 EWC43841.1 - 1.6e-10 40.9 1.1 6.5e-06 25.9 0.2 3.5 3 1 0 3 3 3 2 FAD-NAD(P)-binding K_oxygenase PF13434.1 EWC43841.1 - 9.5e-09 34.6 0.0 4.7e-05 22.4 0.0 3.1 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.9 EWC43841.1 - 1e-07 32.0 0.0 0.00013 21.9 0.0 2.3 1 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 EWC43841.1 - 6.7e-07 29.2 0.0 2.8e-06 27.2 0.0 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 EWC43841.1 - 1.1e-05 24.4 0.1 0.014 14.2 0.1 3.3 3 0 0 3 3 3 1 FAD dependent oxidoreductase Thi4 PF01946.12 EWC43841.1 - 0.00035 19.7 0.0 0.0022 17.1 0.0 2.1 2 0 0 2 2 2 1 Thi4 family HI0933_like PF03486.9 EWC43841.1 - 0.0019 16.7 0.5 1.6 7.0 0.0 3.0 3 0 0 3 3 3 2 HI0933-like protein Lycopene_cycl PF05834.7 EWC43841.1 - 0.01 14.7 0.2 0.035 13.0 0.1 1.9 2 1 0 2 2 2 0 Lycopene cyclase protein GIDA PF01134.17 EWC43841.1 - 0.056 12.3 0.1 1.1 8.0 0.0 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A DUF4246 PF14033.1 EWC43842.1 - 4.6e-111 371.8 0.7 3.4e-79 266.7 0.9 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF4246) 2OG-FeII_Oxy_5 PF13759.1 EWC43842.1 - 0.053 13.8 0.0 0.12 12.6 0.0 1.6 1 0 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase F-box PF00646.28 EWC43842.1 - 0.19 11.4 0.5 3.7 7.3 0.2 2.7 2 0 0 2 2 2 0 F-box domain Baculo_PEP_C PF04513.7 EWC43843.1 - 0.61 9.8 2.9 6 6.6 1.8 2.7 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Granulin PF00396.13 EWC43843.1 - 8.9 6.5 13.7 2.9 8.0 2.7 2.4 1 1 1 2 2 2 0 Granulin MFS_1 PF07690.11 EWC43844.1 - 1.4e-25 89.8 64.8 4.4e-20 71.6 31.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily zf-C2H2 PF00096.21 EWC43845.1 - 1.2e-07 31.6 12.6 0.0003 20.9 2.4 2.5 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EWC43845.1 - 4.2e-06 26.7 10.8 0.00068 19.7 2.6 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.1 EWC43845.1 - 0.0012 19.0 2.4 0.0012 19.0 1.7 2.8 3 0 0 3 3 3 1 Zinc-finger double domain Rtf2 PF04641.7 EWC43845.1 - 0.032 13.4 0.6 0.057 12.6 0.4 1.4 1 0 0 1 1 1 0 Rtf2 RING-finger zf-met PF12874.2 EWC43845.1 - 0.058 13.6 7.1 0.14 12.4 0.7 2.5 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.1 EWC43845.1 - 0.095 12.9 10.4 0.064 13.5 2.2 2.4 2 0 0 2 2 2 0 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.3 EWC43845.1 - 2.8 8.2 6.6 8.2 6.7 1.4 2.6 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding adh_short PF00106.20 EWC43846.1 - 2.8e-20 72.8 0.3 4.4e-20 72.2 0.2 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EWC43846.1 - 2.2e-17 63.6 0.0 3.4e-17 63.0 0.0 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EWC43846.1 - 8.1e-06 25.6 0.1 1.4e-05 24.8 0.1 1.4 1 1 0 1 1 1 1 KR domain Epimerase PF01370.16 EWC43846.1 - 0.00014 21.4 0.0 0.00027 20.4 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Glyco_transf_4 PF13439.1 EWC43846.1 - 0.035 13.8 0.0 0.052 13.2 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase Family 4 DUF1776 PF08643.5 EWC43846.1 - 0.037 13.1 0.0 0.054 12.6 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) NAD_binding_10 PF13460.1 EWC43846.1 - 0.051 13.5 0.8 0.85 9.5 0.2 2.2 2 1 0 2 2 2 0 NADH(P)-binding adh_short PF00106.20 EWC43847.1 - 1.3e-22 80.4 0.7 5.1e-22 78.5 0.5 1.8 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EWC43847.1 - 6.1e-14 52.3 0.0 8.5e-14 51.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EWC43847.1 - 0.00019 21.1 0.2 0.0051 16.5 0.0 2.1 2 0 0 2 2 2 1 KR domain DUF2231 PF09990.4 EWC43847.1 - 0.056 13.7 0.0 0.12 12.7 0.0 1.6 1 0 0 1 1 1 0 Predicted membrane protein (DUF2231) NAD_binding_10 PF13460.1 EWC43847.1 - 0.066 13.2 0.1 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 NADH(P)-binding 3HCDH_N PF02737.13 EWC43847.1 - 0.11 12.1 0.1 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Epimerase PF01370.16 EWC43847.1 - 0.13 11.7 0.1 0.78 9.1 0.0 2.0 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family Beta-lactamase PF00144.19 EWC43848.1 - 4.8e-34 117.8 0.0 7.5e-34 117.2 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase TPR_11 PF13414.1 EWC43849.1 - 6e-15 54.6 0.0 2.2e-11 43.1 0.0 2.4 1 1 1 2 2 2 2 TPR repeat TPR_1 PF00515.23 EWC43849.1 - 1e-06 28.0 0.0 0.0074 15.8 0.0 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.1 EWC43849.1 - 0.00016 22.2 0.0 0.0074 16.9 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.12 EWC43849.1 - 0.00018 21.1 0.0 0.24 11.4 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.1 EWC43849.1 - 0.0038 17.7 0.0 3.3 8.6 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.1 EWC43849.1 - 0.033 13.9 0.0 0.24 11.2 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.1 EWC43849.1 - 0.043 14.2 0.2 7.7 7.2 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_21 PF09976.4 EWC43849.1 - 0.044 13.7 0.1 0.081 12.8 0.1 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_8 PF13181.1 EWC43849.1 - 0.051 13.3 0.2 2.3 8.1 0.0 3.1 2 1 1 3 3 3 0 Tetratricopeptide repeat DIOX_N PF14226.1 EWC43850.1 - 1.4e-33 115.8 0.0 2.2e-33 115.2 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.15 EWC43850.1 - 2.4e-21 75.8 0.0 3.9e-21 75.1 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily F-box PF00646.28 EWC43851.1 - 2.7e-07 30.0 0.1 4.7e-07 29.2 0.1 1.3 1 0 0 1 1 1 1 F-box domain Peptidase_S8 PF00082.17 EWC43852.1 - 3.3e-36 124.8 1.8 5.6e-36 124.1 1.2 1.3 1 0 0 1 1 1 1 Subtilase family Defensin_propep PF00879.13 EWC43852.1 - 0.054 13.4 0.2 0.13 12.2 0.1 1.7 1 0 0 1 1 1 0 Defensin propeptide Inhibitor_I9 PF05922.11 EWC43852.1 - 0.11 13.1 0.0 0.21 12.1 0.0 1.6 1 0 0 1 1 1 0 Peptidase inhibitor I9 Cellulase PF00150.13 EWC43853.1 - 2.8e-20 72.6 7.1 7.8e-20 71.2 4.9 1.7 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Ricin_B_lectin PF00652.17 EWC43853.1 - 9.2e-20 70.9 2.2 2e-19 69.8 1.5 1.5 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain RicinB_lectin_2 PF14200.1 EWC43853.1 - 3e-11 43.6 0.4 0.00021 21.6 0.0 2.8 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain-like Glyco_hydro_42 PF02449.10 EWC43853.1 - 8.6e-06 25.1 0.0 2.6e-05 23.4 0.0 1.7 2 0 0 2 2 2 1 Beta-galactosidase Glyco_hydro_1 PF00232.13 EWC43853.1 - 0.00019 19.7 0.2 0.00031 19.0 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 Glyco_hydro_72 PF03198.9 EWC43853.1 - 0.0033 16.4 0.3 0.0067 15.4 0.2 1.4 1 1 0 1 1 1 1 Glucanosyltransferase Glyco_hydro_35 PF01301.14 EWC43853.1 - 0.013 14.8 0.1 0.026 13.8 0.1 1.4 1 0 0 1 1 1 0 Glycosyl hydrolases family 35 DUF3252 PF11623.3 EWC43853.1 - 0.082 12.3 0.1 0.17 11.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3252) DUF3194 PF11419.3 EWC43854.1 - 6.9e-06 26.1 34.2 1.5e+04 -15.2 23.7 4.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3194) DUF1943 PF09172.6 EWC43854.1 - 0.00049 19.0 27.7 2.8e+03 -3.2 19.2 3.4 1 1 0 1 1 1 0 Domain of unknown function (DUF1943) Noc2 PF03715.8 EWC43855.1 - 8.7e-115 382.6 0.0 2.7e-114 381.0 0.0 1.9 2 0 0 2 2 2 1 Noc2p family LemA PF04011.7 EWC43855.1 - 0.19 10.8 3.4 0.38 9.8 2.4 1.5 1 0 0 1 1 1 0 LemA family Nop14 PF04147.7 EWC43855.1 - 0.67 7.7 0.0 0.67 7.7 0.0 3.9 3 1 0 3 3 3 0 Nop14-like family DUF2360 PF10152.4 EWC43856.1 - 0.58 10.4 6.1 0.16 12.2 1.0 2.2 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein (DUF2360) DUF4234 PF14018.1 EWC43857.1 - 0.23 11.2 2.6 0.89 9.3 1.8 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4234) GspL_C PF12693.2 EWC43857.1 - 0.5 10.1 2.1 1.9 8.2 1.5 1.9 2 0 0 2 2 2 0 GspL periplasmic domain CLTH PF10607.4 EWC43858.1 - 3.2e-29 101.4 0.0 5e-29 100.8 0.0 1.3 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain zf-RING_UBOX PF13445.1 EWC43858.1 - 4.6e-18 64.6 0.8 8.6e-18 63.7 0.6 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.1 EWC43858.1 - 0.00059 19.6 0.2 0.00097 18.9 0.2 1.4 1 0 0 1 1 1 1 Ring finger domain Rtf2 PF04641.7 EWC43858.1 - 0.00062 19.0 0.0 0.00089 18.5 0.0 1.2 1 0 0 1 1 1 1 Rtf2 RING-finger zf-C3HC4_2 PF13923.1 EWC43858.1 - 0.00068 19.6 0.5 0.0012 18.8 0.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 EWC43858.1 - 0.0066 16.0 0.1 0.01 15.4 0.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EWC43858.1 - 0.007 15.9 0.4 0.013 15.1 0.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EWC43858.1 - 0.01 15.5 0.1 0.017 14.8 0.1 1.3 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_4 PF15227.1 EWC43858.1 - 0.019 14.8 0.6 0.037 13.9 0.4 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-Nse PF11789.3 EWC43858.1 - 0.12 11.9 1.3 0.23 10.9 0.9 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Utp11 PF03998.8 EWC43859.1 - 1.1e-53 182.5 7.3 1.3e-53 182.3 5.1 1.1 1 0 0 1 1 1 1 Utp11 protein DUF4077 PF13295.1 EWC43860.1 - 0.048 13.3 5.7 0.086 12.5 4.0 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4077) NADH_B2 PF14813.1 EWC43860.1 - 0.22 11.2 1.0 0.38 10.4 0.7 1.3 1 0 0 1 1 1 0 NADH dehydrogenase 1 beta subcomplex subunit 2 CbtA PF09490.5 EWC43860.1 - 0.59 9.4 9.2 0.71 9.1 6.4 1.1 1 0 0 1 1 1 0 Probable cobalt transporter subunit (CbtA) LRR_4 PF12799.2 EWC43861.1 - 1e-39 133.5 31.8 3e-10 39.4 3.9 6.9 5 1 3 8 8 8 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 EWC43861.1 - 6.6e-25 86.6 60.1 2.1e-07 30.6 4.0 5.2 1 1 4 6 6 6 6 Leucine rich repeat LRR_6 PF13516.1 EWC43861.1 - 8.5e-13 46.9 22.8 0.032 14.2 0.1 9.6 6 3 3 9 9 9 4 Leucine Rich repeat LRR_7 PF13504.1 EWC43861.1 - 9.3e-13 46.1 17.1 0.62 10.5 0.1 10.0 11 0 0 11 11 11 4 Leucine rich repeat LRR_1 PF00560.28 EWC43861.1 - 1.8e-12 45.4 31.0 0.2 11.8 0.1 10.9 11 1 1 12 12 12 5 Leucine Rich Repeat LRR_9 PF14580.1 EWC43861.1 - 2.2e-10 40.3 12.7 8.6e-06 25.4 0.9 3.6 1 1 3 4 4 4 4 Leucine-rich repeat MUG2_C PF08593.5 EWC43861.1 - 0.13 12.5 2.3 9.5 6.5 0.1 3.8 3 0 0 3 3 3 0 Meiotically up-regulated glycoproteins C-terminal PCI PF01399.22 EWC43862.1 - 4.7e-13 49.3 0.0 1.4e-12 47.8 0.0 1.8 1 0 0 1 1 1 1 PCI domain Cmc1 PF08583.5 EWC43863.1 - 3.5e-20 71.5 5.4 3.5e-20 71.5 3.7 1.5 2 0 0 2 2 2 1 Cytochrome c oxidase biogenesis protein Cmc1 like CHCH PF06747.8 EWC43863.1 - 0.00014 21.7 1.2 0.0002 21.2 0.8 1.3 1 0 0 1 1 1 1 CHCH domain NDUF_B7 PF05676.8 EWC43863.1 - 0.0021 17.4 2.0 0.0035 16.7 1.4 1.4 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) DUF3128 PF11326.3 EWC43863.1 - 0.21 11.7 5.3 0.47 10.6 3.7 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3128) COX17 PF05051.8 EWC43863.1 - 0.32 11.0 2.5 4.2 7.4 0.1 2.3 2 0 0 2 2 2 0 Cytochrome C oxidase copper chaperone (COX17) Zn_Tnp_IS91 PF14319.1 EWC43863.1 - 0.41 10.1 5.4 0.55 9.7 3.7 1.2 1 0 0 1 1 1 0 Transposase zinc-binding domain Bac_luciferase PF00296.15 EWC43863.1 - 0.42 9.6 5.0 0.61 9.1 3.4 1.2 1 0 0 1 1 1 0 Luciferase-like monooxygenase DUF2404 PF10296.4 EWC43864.1 - 0.036 14.2 0.0 0.39 10.8 0.0 2.2 2 0 0 2 2 2 0 Putative integral membrane protein conserved region (DUF2404) TFIID-31kDa PF02291.10 EWC43865.1 - 7.5e-41 138.9 0.0 9.6e-41 138.5 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit GAS PF13851.1 EWC43867.1 - 9.1e-08 31.5 25.3 0.00015 21.0 7.8 2.4 2 1 0 2 2 2 2 Growth-arrest specific micro-tubule binding Reo_sigmaC PF04582.7 EWC43867.1 - 0.0012 18.0 3.3 0.021 14.0 0.6 2.3 1 1 1 2 2 2 1 Reovirus sigma C capsid protein CENP-F_leu_zip PF10473.4 EWC43867.1 - 0.0031 17.3 4.9 0.0031 17.3 3.4 3.5 2 1 1 3 3 3 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 IncA PF04156.9 EWC43867.1 - 0.25 10.9 30.1 0.5 9.9 6.5 3.0 1 1 1 3 3 3 0 IncA protein HALZ PF02183.13 EWC43867.1 - 0.47 10.2 17.2 3.6 7.3 0.4 5.5 2 2 4 6 6 6 0 Homeobox associated leucine zipper APG6 PF04111.7 EWC43867.1 - 1.1 8.2 30.6 1.1 8.2 8.1 2.9 1 1 2 3 3 3 0 Autophagy protein Apg6 Seryl_tRNA_N PF02403.17 EWC43867.1 - 4.8 7.2 19.7 0.59 10.1 0.3 3.7 1 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain ERM PF00769.14 EWC43867.1 - 8.2 5.8 28.9 0.35 10.3 6.3 3.3 1 1 2 3 3 3 0 Ezrin/radixin/moesin family fn3 PF00041.16 EWC43870.1 - 1.5e-10 41.0 0.1 3.5e-10 39.8 0.0 1.7 1 0 0 1 1 1 1 Fibronectin type III domain LemA PF04011.7 EWC43870.1 - 0.17 10.9 4.7 0.31 10.1 3.2 1.3 1 0 0 1 1 1 0 LemA family DUF812 PF05667.6 EWC43870.1 - 0.92 7.9 29.7 3.1 6.1 20.6 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF812) DUF3584 PF12128.3 EWC43870.1 - 8.2 3.5 29.2 13 2.9 20.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) LNS2 PF08235.8 EWC43871.1 - 1.6e-69 232.4 0.0 2.8e-69 231.6 0.0 1.4 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.9 EWC43871.1 - 3.3e-39 132.9 0.0 8.5e-39 131.6 0.0 1.7 1 0 0 1 1 1 1 lipin, N-terminal conserved region AlaDh_PNT_N PF05222.10 EWC43872.1 - 1.4e-25 89.8 0.0 2e-25 89.3 0.0 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain AlaDh_PNT_C PF01262.16 EWC43872.1 - 2.9e-09 36.7 0.1 2.4e-08 33.7 0.1 2.1 1 1 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain RNA_pol_Rpb1_1 PF04997.7 EWC43873.1 - 2.1e-118 395.4 0.0 4.3e-118 394.4 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.12 EWC43873.1 - 3.5e-106 354.4 0.2 6e-106 353.7 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.15 EWC43873.1 - 2.8e-70 235.5 0.0 5.5e-70 234.6 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_6 PF04992.9 EWC43873.1 - 1.4e-57 194.5 1.1 2.4e-57 193.7 0.8 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_3 PF04983.13 EWC43873.1 - 5.4e-46 156.2 0.0 1.2e-45 155.0 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_7 PF04990.7 EWC43873.1 - 2.8e-41 140.3 4.4 6.2e-41 139.2 3.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 7 RNA_pol_Rpb1_4 PF05000.12 EWC43873.1 - 1.9e-36 124.0 0.2 4.9e-36 122.7 0.2 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_R PF05001.8 EWC43873.1 - 2e-05 24.2 211.0 0.0078 16.2 5.7 14.4 11 2 4 17 17 17 10 RNA polymerase Rpb1 C-terminal repeat WD40 PF00400.27 EWC43874.1 - 5.9e-17 60.8 6.5 1.2e-09 37.7 0.6 4.8 4 0 0 4 4 4 3 WD domain, G-beta repeat eIF2A PF08662.6 EWC43874.1 - 0.00018 21.3 0.0 0.91 9.2 0.0 3.0 3 0 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A Coatomer_WDAD PF04053.9 EWC43874.1 - 0.025 13.3 0.0 0.048 12.4 0.0 1.4 1 0 0 1 1 1 0 Coatomer WD associated region Cytochrom_D1 PF02239.11 EWC43874.1 - 0.037 12.3 0.6 1.5 7.0 0.0 2.7 2 1 1 3 3 3 0 Cytochrome D1 heme domain PCI PF01399.22 EWC43875.1 - 5.3e-07 29.9 0.1 1.3e-06 28.6 0.1 1.6 1 1 1 2 2 2 1 PCI domain FG-GAP PF01839.18 EWC43877.1 - 9.2e-05 22.0 12.2 0.0025 17.4 2.7 2.9 1 1 1 2 2 2 2 FG-GAP repeat VCBS PF13517.1 EWC43877.1 - 0.00019 21.7 6.0 0.033 14.5 0.6 3.0 2 0 0 2 2 2 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella EF-hand_5 PF13202.1 EWC43877.1 - 0.016 14.5 3.2 4.8 6.7 0.0 3.4 3 0 0 3 3 3 0 EF hand TcdB_toxin_midN PF12256.3 EWC43877.1 - 0.19 11.1 2.3 0.84 9.0 1.6 2.0 1 1 0 1 1 1 0 Insecticide toxin TcdB middle/N-terminal region EF-hand_1 PF00036.27 EWC43877.1 - 0.23 10.8 2.0 25 4.4 0.0 3.2 3 0 0 3 3 3 0 EF hand Trypan_PARP PF05887.6 EWC43877.1 - 0.87 9.3 15.8 0.029 14.2 6.3 1.9 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) E1-E2_ATPase PF00122.15 EWC43878.1 - 3.1e-50 170.3 0.1 3.1e-50 170.3 0.1 1.8 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.21 EWC43878.1 - 1e-44 153.5 2.3 1e-44 153.5 1.6 2.1 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase HMA PF00403.21 EWC43878.1 - 3.7e-44 148.6 3.1 1.8e-12 47.2 0.1 4.4 4 0 0 4 4 4 4 Heavy-metal-associated domain HAD PF12710.2 EWC43878.1 - 2.4e-12 47.4 0.0 5.4e-12 46.2 0.0 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 EWC43878.1 - 2.9e-06 27.0 2.6 0.00035 20.2 1.4 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase B12-binding PF02310.14 EWC43878.1 - 0.024 14.5 0.3 15 5.5 0.0 3.6 3 0 0 3 3 3 0 B12 binding domain Thg1C PF14413.1 EWC43879.1 - 1.8e-47 160.0 0.7 5.3e-47 158.4 0.5 1.7 1 1 0 1 1 1 1 Thg1 C terminal domain Thg1 PF04446.7 EWC43879.1 - 7.2e-44 148.6 0.0 1.1e-43 148.1 0.0 1.2 1 0 0 1 1 1 1 tRNAHis guanylyltransferase Peptidase_M16 PF00675.15 EWC43880.1 - 1.4e-56 190.4 0.6 3.8e-56 188.9 0.3 1.8 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.16 EWC43880.1 - 2.6e-40 138.0 0.0 3.2e-39 134.4 0.0 2.5 3 0 0 3 3 3 1 Peptidase M16 inactive domain CybS PF05328.7 EWC43881.1 - 6.5e-50 168.1 0.0 9.6e-50 167.6 0.0 1.3 1 1 0 1 1 1 1 CybS Apolipoprotein PF01442.13 EWC43882.1 - 1.3e-07 31.3 0.9 1.3e-07 31.3 0.6 2.4 2 0 0 2 2 2 1 Apolipoprotein A1/A4/E domain Baculo_PEP_C PF04513.7 EWC43882.1 - 0.00022 21.0 4.1 0.00022 21.0 2.8 2.5 3 1 0 3 3 3 1 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1515 PF07439.6 EWC43882.1 - 0.027 14.2 2.9 0.047 13.4 1.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1515) MtrG PF04210.8 EWC43882.1 - 0.1 12.3 1.2 6.2 6.5 0.1 2.9 1 1 1 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, subunit G Prominin PF05478.6 EWC43882.1 - 0.88 7.0 8.4 13 3.1 0.0 2.6 2 1 0 2 2 2 0 Prominin Laminin_II PF06009.7 EWC43882.1 - 1.1 9.0 14.8 0.28 10.9 0.6 3.6 4 0 0 4 4 4 0 Laminin Domain II Cortex-I_coil PF09304.5 EWC43882.1 - 3 7.9 9.9 4.1 7.4 0.4 3.5 2 2 1 3 3 3 0 Cortexillin I, coiled coil Fib_alpha PF08702.5 EWC43882.1 - 7.8 6.6 15.2 4.8 7.2 1.4 3.2 1 1 0 3 3 3 0 Fibrinogen alpha/beta chain family FlaC_arch PF05377.6 EWC43882.1 - 10 6.1 8.7 1.2 9.0 0.2 3.5 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) G-patch PF01585.18 EWC43883.1 - 0.093 12.5 0.0 0.24 11.2 0.0 1.6 1 0 0 1 1 1 0 G-patch domain Ada3 PF10198.4 EWC43884.1 - 4.5e-42 142.9 0.8 4.5e-42 142.9 0.5 2.1 2 0 0 2 2 2 1 Histone acetyltransferases subunit 3 UPF0565 PF10561.4 EWC43884.1 - 0.056 12.3 2.1 0.11 11.4 1.5 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 SOBP PF15279.1 EWC43884.1 - 5.7 7.2 9.4 10 6.3 6.5 1.4 1 0 0 1 1 1 0 Sine oculis-binding protein CoA_transf_3 PF02515.12 EWC43885.1 - 4.1e-49 166.4 0.0 5.8e-49 165.9 0.0 1.2 1 0 0 1 1 1 1 CoA-transferase family III F-box-like PF12937.2 EWC43886.1 - 0.016 14.9 0.0 0.032 13.9 0.0 1.5 1 0 0 1 1 1 0 F-box-like Amidohydro_1 PF01979.15 EWC43887.1 - 2.4e-62 211.5 1.2 4.1e-62 210.7 0.8 1.4 1 0 0 1 1 1 1 Amidohydrolase family Urease_alpha PF00449.15 EWC43887.1 - 7e-56 187.5 5.0 7.8e-55 184.1 2.2 2.4 2 0 0 2 2 2 1 Urease alpha-subunit, N-terminal domain Urease_beta PF00699.15 EWC43887.1 - 8.2e-42 141.1 1.2 2.2e-41 139.7 0.2 2.1 2 0 0 2 2 2 1 Urease beta subunit Urease_gamma PF00547.13 EWC43887.1 - 4.9e-39 132.3 0.2 1e-38 131.3 0.1 1.6 1 0 0 1 1 1 1 Urease, gamma subunit Amidohydro_3 PF07969.6 EWC43887.1 - 1.3e-05 24.6 0.1 3.7e-05 23.1 0.1 1.8 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_5 PF13594.1 EWC43887.1 - 7.1e-05 22.5 3.4 0.00018 21.2 2.4 1.7 1 0 0 1 1 1 1 Amidohydrolase HMG_box PF00505.14 EWC43888.1 - 3.7e-13 49.5 2.7 8.5e-13 48.3 1.9 1.7 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 EWC43888.1 - 2.3e-06 27.8 2.4 2.3e-06 27.8 1.7 2.1 2 0 0 2 2 2 1 HMG-box domain FadA PF09403.5 EWC43888.1 - 0.058 13.4 0.1 0.058 13.4 0.1 2.1 3 0 0 3 3 3 0 Adhesion protein FadA Herpes_pp85 PF04637.7 EWC43888.1 - 1.2 7.3 5.7 1.4 7.1 4.0 1.2 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) Pyridoxal_deC PF00282.14 EWC43890.1 - 1.8e-74 250.4 0.0 2.3e-74 250.1 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.16 EWC43890.1 - 3.7e-07 29.5 0.0 5.4e-07 29.0 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.14 EWC43890.1 - 6.9e-05 21.7 0.0 0.00012 20.9 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.16 EWC43890.1 - 0.034 13.0 0.0 1.3 7.8 0.0 2.1 2 0 0 2 2 2 0 Aminotransferase class I and II Ank_2 PF12796.2 EWC43892.1 - 1.9e-133 435.1 30.3 1.6e-16 60.3 0.3 13.3 4 1 8 13 13 13 13 Ankyrin repeats (3 copies) Ank PF00023.25 EWC43892.1 - 2.5e-101 326.7 22.2 4e-08 32.6 0.0 24.8 25 0 0 25 25 25 16 Ankyrin repeat Ank_4 PF13637.1 EWC43892.1 - 2.1e-83 273.3 25.0 1.8e-13 50.5 0.0 18.7 11 4 11 22 22 22 16 Ankyrin repeats (many copies) Ank_3 PF13606.1 EWC43892.1 - 1.6e-80 256.8 27.0 0.0001 22.1 0.0 26.8 28 0 0 28 28 28 16 Ankyrin repeat Ank_5 PF13857.1 EWC43892.1 - 1.7e-74 244.1 28.2 8.4e-11 41.7 0.0 20.4 8 4 16 24 24 24 17 Ankyrin repeats (many copies) SPRY PF00622.23 EWC43892.1 - 4.5e-11 42.8 0.1 1.1e-10 41.7 0.0 1.6 1 0 0 1 1 1 1 SPRY domain AAA_16 PF13191.1 EWC43892.1 - 0.00074 19.5 0.0 0.0059 16.6 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain ABC_tran PF00005.22 EWC43892.1 - 0.0049 17.1 0.0 0.02 15.1 0.0 2.0 2 0 0 2 2 2 1 ABC transporter Shigella_OspC PF06128.6 EWC43892.1 - 0.041 13.3 0.3 0.57 9.6 0.0 3.0 3 1 1 4 4 4 0 Shigella flexneri OspC protein AAA_10 PF12846.2 EWC43892.1 - 0.049 13.0 0.0 0.1 12.0 0.0 1.5 1 0 0 1 1 1 0 AAA-like domain Arch_ATPase PF01637.13 EWC43892.1 - 0.11 12.1 0.0 0.23 11.1 0.0 1.4 1 0 0 1 1 1 0 Archaeal ATPase Myosin_head PF00063.16 EWC43892.1 - 0.34 8.9 0.0 0.52 8.2 0.0 1.2 1 0 0 1 1 1 0 Myosin head (motor domain) Peptidase_S8 PF00082.17 EWC43894.1 - 2.3e-17 63.0 0.0 4.2e-17 62.1 0.0 1.4 1 0 0 1 1 1 1 Subtilase family Ank PF00023.25 EWC43894.1 - 0.0006 19.5 0.0 0.0023 17.6 0.0 2.0 1 0 0 1 1 1 1 Ankyrin repeat Ank_2 PF12796.2 EWC43894.1 - 0.014 15.7 0.4 0.057 13.7 0.3 2.1 1 1 0 1 1 1 0 Ankyrin repeats (3 copies) DcpS_C PF11969.3 EWC43894.1 - 0.014 15.6 0.1 0.031 14.4 0.1 1.5 1 0 0 1 1 1 0 Scavenger mRNA decapping enzyme C-term binding Ank_4 PF13637.1 EWC43894.1 - 0.06 13.8 0.2 1.5 9.4 0.0 3.2 3 1 0 3 3 3 0 Ankyrin repeats (many copies) E1-E2_ATPase PF00122.15 EWC43895.1 - 2.6e-63 213.1 1.8 5e-63 212.2 1.2 1.5 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 EWC43895.1 - 6.7e-31 107.2 9.1 6.7e-31 107.2 6.3 2.2 2 1 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 EWC43895.1 - 1.3e-30 107.4 0.0 3.3e-29 102.8 0.0 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 EWC43895.1 - 1.3e-15 58.1 0.0 2.4e-15 57.1 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 EWC43895.1 - 3.6e-15 55.6 0.0 7.2e-15 54.7 0.0 1.5 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 EWC43895.1 - 0.00026 20.6 0.1 0.0045 16.5 0.2 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Lipase_3 PF01764.20 EWC43896.1 - 5.3e-28 97.3 0.0 7.3e-28 96.9 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_5 PF12695.2 EWC43896.1 - 0.063 13.0 0.0 0.086 12.5 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family AAA PF00004.24 EWC43897.1 - 6e-43 146.2 0.0 1.3e-42 145.1 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 EWC43897.1 - 2.7e-07 30.7 0.0 9.9e-06 25.6 0.0 2.6 2 1 1 3 3 3 1 AAA ATPase domain AAA_5 PF07728.9 EWC43897.1 - 1.2e-06 28.2 0.2 2.6e-05 23.9 0.1 2.7 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.9 EWC43897.1 - 1.9e-06 27.9 0.0 5.1e-06 26.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.1 EWC43897.1 - 2.7e-06 27.5 0.0 0.00052 20.1 0.0 2.5 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.7 EWC43897.1 - 7.9e-06 25.0 0.0 1.5e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus DUF815 PF05673.8 EWC43897.1 - 0.00012 21.0 0.0 0.00062 18.7 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_19 PF13245.1 EWC43897.1 - 0.00016 21.3 0.1 0.00044 19.9 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain AAA_17 PF13207.1 EWC43897.1 - 0.00073 20.3 0.2 0.0021 18.8 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.1 EWC43897.1 - 0.0016 18.3 0.0 0.0032 17.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 EWC43897.1 - 0.0019 18.1 0.0 0.0061 16.4 0.0 1.9 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.16 EWC43897.1 - 0.0021 17.2 0.0 0.0044 16.2 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI TIP49 PF06068.8 EWC43897.1 - 0.0028 16.4 0.0 0.0047 15.6 0.0 1.3 1 0 0 1 1 1 1 TIP49 C-terminus IstB_IS21 PF01695.12 EWC43897.1 - 0.0031 16.9 0.0 0.0061 15.9 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_18 PF13238.1 EWC43897.1 - 0.0039 17.4 0.2 0.016 15.5 0.0 2.2 2 1 0 2 2 2 1 AAA domain RNA_helicase PF00910.17 EWC43897.1 - 0.005 17.0 0.0 0.0094 16.1 0.0 1.5 1 0 0 1 1 1 1 RNA helicase AAA_24 PF13479.1 EWC43897.1 - 0.0056 16.2 0.1 0.012 15.2 0.1 1.5 1 0 0 1 1 1 1 AAA domain Sigma54_activat PF00158.21 EWC43897.1 - 0.0076 15.7 0.0 0.025 14.0 0.0 1.9 1 1 0 1 1 1 1 Sigma-54 interaction domain Zeta_toxin PF06414.7 EWC43897.1 - 0.0077 15.3 0.0 0.02 14.0 0.0 1.6 1 0 0 1 1 1 1 Zeta toxin AAA_3 PF07726.6 EWC43897.1 - 0.0099 15.4 0.0 0.02 14.4 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.1 EWC43897.1 - 0.01 15.2 0.1 0.063 12.6 0.1 2.1 1 1 1 2 2 2 0 AAA domain DUF4200 PF13863.1 EWC43897.1 - 0.014 15.3 0.4 0.035 14.0 0.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) AAA_28 PF13521.1 EWC43897.1 - 0.016 15.1 0.0 0.032 14.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain ResIII PF04851.10 EWC43897.1 - 0.02 14.7 0.0 0.048 13.4 0.0 1.7 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit KaiC PF06745.8 EWC43897.1 - 0.022 13.8 0.2 0.096 11.7 0.0 2.2 3 0 0 3 3 2 0 KaiC Arch_ATPase PF01637.13 EWC43897.1 - 0.022 14.4 0.1 0.14 11.8 0.0 2.3 2 1 0 2 2 2 0 Archaeal ATPase NACHT PF05729.7 EWC43897.1 - 0.026 14.1 0.0 0.076 12.6 0.0 1.8 2 0 0 2 2 2 0 NACHT domain PhoH PF02562.11 EWC43897.1 - 0.033 13.4 0.0 0.059 12.5 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein AAA_30 PF13604.1 EWC43897.1 - 0.037 13.6 0.1 0.098 12.2 0.0 1.7 2 0 0 2 2 1 0 AAA domain AAA_11 PF13086.1 EWC43897.1 - 0.044 13.3 0.1 0.29 10.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain Sigma54_activ_2 PF14532.1 EWC43897.1 - 0.051 13.6 0.0 0.13 12.3 0.0 1.8 1 1 0 1 1 1 0 Sigma-54 interaction domain UPF0079 PF02367.12 EWC43897.1 - 0.052 13.1 0.0 0.1 12.2 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 Parvo_NS1 PF01057.12 EWC43897.1 - 0.064 12.1 0.0 0.11 11.3 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 CPT PF07931.7 EWC43897.1 - 0.11 12.0 0.0 0.23 11.0 0.0 1.5 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_23 PF13476.1 EWC43897.1 - 0.14 12.5 2.4 9.7 6.4 0.0 2.5 2 1 0 2 2 2 0 AAA domain Enolase_C PF00113.17 EWC43898.1 - 5.2e-151 501.6 0.1 7.2e-151 501.1 0.0 1.2 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.11 EWC43898.1 - 1.8e-54 183.2 0.1 3e-54 182.5 0.1 1.4 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.1 EWC43898.1 - 0.004 17.1 0.0 0.011 15.7 0.0 1.7 1 0 0 1 1 1 1 Enolase C-terminal domain-like F-box-like PF12937.2 EWC43899.1 - 0.082 12.6 0.2 0.18 11.5 0.1 1.6 1 0 0 1 1 1 0 F-box-like Pro_isomerase PF00160.16 EWC43901.1 - 7.9e-46 156.0 0.8 1.1e-45 155.6 0.5 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD CPSase_L_D2 PF02786.12 EWC43902.1 - 4.9e-82 274.3 0.0 7.7e-82 273.6 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain PYC_OADA PF02436.13 EWC43902.1 - 1.6e-66 223.5 0.0 2.9e-66 222.6 0.0 1.5 1 0 0 1 1 1 1 Conserved carboxylase domain CPSase_L_chain PF00289.17 EWC43902.1 - 5.3e-35 119.8 0.1 1.3e-34 118.6 0.1 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, N-terminal domain Biotin_carb_C PF02785.14 EWC43902.1 - 7.6e-31 106.2 0.0 3.5e-30 104.1 0.0 2.2 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain HMGL-like PF00682.14 EWC43902.1 - 6e-27 94.8 0.1 1.1e-26 93.9 0.0 1.5 1 0 0 1 1 1 1 HMGL-like Biotin_lipoyl PF00364.17 EWC43902.1 - 3.5e-18 65.0 3.7 1.1e-17 63.4 2.6 1.9 1 0 0 1 1 1 1 Biotin-requiring enzyme ATP-grasp_4 PF13535.1 EWC43902.1 - 4.2e-17 62.4 0.1 8.5e-17 61.4 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_Ter PF15632.1 EWC43902.1 - 2.7e-15 55.9 0.0 2.4e-14 52.8 0.0 2.0 1 1 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon Biotin_lipoyl_2 PF13533.1 EWC43902.1 - 4.6e-12 45.4 2.5 6.3e-09 35.3 0.2 3.0 1 1 1 2 2 2 2 Biotin-lipoyl like Dala_Dala_lig_C PF07478.8 EWC43902.1 - 1.4e-11 44.1 0.0 3e-11 43.1 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.17 EWC43902.1 - 1.3e-06 27.8 0.0 2.9e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain HlyD_3 PF13437.1 EWC43902.1 - 7e-05 23.1 0.9 0.0057 16.9 0.2 3.4 2 1 0 2 2 2 1 HlyD family secretion protein RimK PF08443.6 EWC43902.1 - 7.8e-05 22.2 0.0 0.00021 20.8 0.0 1.7 1 1 0 1 1 1 1 RimK-like ATP-grasp domain HlyD PF00529.15 EWC43902.1 - 0.00019 20.8 0.3 0.0013 18.1 0.1 2.2 2 0 0 2 2 2 1 HlyD family secretion protein ATP-grasp_3 PF02655.9 EWC43902.1 - 0.00023 21.0 0.1 0.0007 19.4 0.0 1.9 2 0 0 2 2 1 1 ATP-grasp domain HlyD_2 PF12700.2 EWC43902.1 - 0.00056 19.1 0.3 0.016 14.3 0.1 2.2 1 1 1 2 2 2 1 HlyD family secretion protein RnfC_N PF13375.1 EWC43902.1 - 0.022 14.4 2.4 0.11 12.2 1.3 2.4 2 1 0 2 2 1 0 RnfC Barrel sandwich hybrid domain GARS_A PF01071.14 EWC43902.1 - 0.023 14.2 0.0 0.049 13.1 0.0 1.5 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain DUF2118 PF09891.4 EWC43902.1 - 0.03 14.0 0.1 0.079 12.6 0.0 1.7 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2118) NQRA PF05896.6 EWC43902.1 - 0.051 12.7 0.2 0.09 11.9 0.1 1.3 1 0 0 1 1 1 0 Na(+)-translocating NADH-quinone reductase subunit A (NQRA) Rieske PF00355.21 EWC43902.1 - 0.077 12.5 0.0 0.19 11.2 0.0 1.6 1 0 0 1 1 1 0 Rieske [2Fe-2S] domain GCV_H PF01597.14 EWC43902.1 - 0.082 12.5 2.4 0.2 11.3 0.4 2.5 2 1 1 3 3 2 0 Glycine cleavage H-protein PYNP_C PF07831.8 EWC43902.1 - 0.3 10.5 2.6 1.1 8.7 0.0 2.9 3 0 0 3 3 3 0 Pyrimidine nucleoside phosphorylase C-terminal domain Clathrin PF00637.15 EWC43903.1 - 3.2e-202 662.2 32.4 1e-33 115.9 0.2 7.9 8 0 0 8 8 8 7 Region in Clathrin and VPS Clathrin_propel PF01394.15 EWC43903.1 - 4.3e-34 114.4 1.0 5.9e-06 26.2 0.0 7.6 7 0 0 7 7 7 6 Clathrin propeller repeat Clathrin_H_link PF13838.1 EWC43903.1 - 1.7e-28 98.2 0.2 9.7e-28 95.8 0.1 2.5 2 0 0 2 2 2 1 Clathrin-H-link TPR_7 PF13176.1 EWC43903.1 - 0.00083 18.9 6.0 19 5.3 0.0 6.8 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_2 PF07719.12 EWC43903.1 - 0.00084 19.0 1.1 11 6.1 0.1 5.7 5 0 0 5 5 5 1 Tetratricopeptide repeat Coatomer_WDAD PF04053.9 EWC43903.1 - 0.0012 17.7 4.8 0.071 11.9 0.1 4.1 4 0 0 4 4 4 1 Coatomer WD associated region TPR_12 PF13424.1 EWC43903.1 - 0.0034 17.2 3.3 34 4.4 0.1 5.7 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.23 EWC43903.1 - 0.0038 16.7 1.5 9.6 6.0 0.1 5.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.1 EWC43903.1 - 0.013 15.1 0.3 32 4.6 0.0 4.4 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF1467 PF07330.7 EWC43904.1 - 0.19 11.5 1.1 0.21 11.3 0.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1467) Auxin_canalis PF05703.6 EWC43904.1 - 0.75 9.5 5.0 0.47 10.2 0.3 1.9 2 0 0 2 2 2 0 Auxin canalisation ArfGap PF01412.13 EWC43906.1 - 4.5e-35 119.9 0.6 1.5e-34 118.2 0.0 2.2 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf PH PF00169.24 EWC43906.1 - 8.7e-13 48.3 0.0 2.8e-12 46.7 0.0 2.0 1 0 0 1 1 1 1 PH domain Ank_2 PF12796.2 EWC43906.1 - 0.12 12.7 0.1 0.57 10.5 0.1 2.1 1 1 0 1 1 1 0 Ankyrin repeats (3 copies) Ank_4 PF13637.1 EWC43906.1 - 0.12 12.8 0.1 4 8.0 0.1 2.5 2 0 0 2 2 2 0 Ankyrin repeats (many copies) Prion_bPrPp PF11587.3 EWC43907.1 - 0.22 11.2 2.5 0.46 10.1 1.7 1.5 1 0 0 1 1 1 0 Major prion protein bPrPp - N terminal LSM PF01423.17 EWC43908.1 - 1.4e-15 56.5 0.0 1.8e-15 56.2 0.0 1.1 1 0 0 1 1 1 1 LSM domain Ribosomal_L5_C PF00673.16 EWC43909.1 - 1.1e-21 76.3 0.0 1.5e-21 75.8 0.0 1.2 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.14 EWC43909.1 - 2.3e-21 75.3 0.1 6.2e-21 73.9 0.0 1.7 2 0 0 2 2 2 1 Ribosomal protein L5 RhoGAP PF00620.22 EWC43911.1 - 1e-42 145.3 0.1 2e-42 144.3 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.24 EWC43911.1 - 5.9e-11 42.4 0.2 2.3e-10 40.5 0.0 2.1 2 0 0 2 2 2 1 PH domain Rabaptin PF03528.10 EWC43911.1 - 0.0016 18.2 3.0 0.0016 18.2 2.1 1.9 2 0 0 2 2 2 1 Rabaptin DUF3450 PF11932.3 EWC43911.1 - 0.0025 17.1 1.0 0.0025 17.1 0.7 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3450) PH_11 PF15413.1 EWC43911.1 - 0.0046 17.2 0.0 0.012 15.8 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.1 EWC43911.1 - 0.15 12.1 0.0 0.48 10.5 0.0 1.8 1 0 0 1 1 1 0 Pleckstrin homology domain Macoilin PF09726.4 EWC43911.1 - 1.9 6.6 12.2 3.7 5.7 8.4 1.4 1 0 0 1 1 1 0 Transmembrane protein CFEM PF05730.6 EWC43912.1 - 7e-07 28.9 1.6 1.2e-06 28.2 1.1 1.3 1 0 0 1 1 1 1 CFEM domain TIL PF01826.12 EWC43912.1 - 0.43 10.7 4.1 0.91 9.6 2.8 1.5 1 0 0 1 1 1 0 Trypsin Inhibitor like cysteine rich domain WBS_methylT PF12589.3 EWC43914.1 - 9.5e-17 61.2 7.5 1.8e-16 60.4 5.2 1.4 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_11 PF08241.7 EWC43914.1 - 7.5e-15 55.1 0.0 1.9e-14 53.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EWC43914.1 - 9.4e-09 35.0 0.0 1.7e-08 34.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EWC43914.1 - 2.3e-07 31.3 0.2 1.5e-06 28.7 0.0 2.1 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 EWC43914.1 - 5e-07 30.0 0.0 1.1e-06 28.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EWC43914.1 - 8.8e-07 29.3 0.0 2.5e-06 27.8 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EWC43914.1 - 3.1e-06 26.9 0.0 4.9e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 EWC43914.1 - 0.00023 20.7 0.0 0.0004 19.9 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_26 PF13659.1 EWC43914.1 - 0.00029 20.8 0.0 0.00058 19.8 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 EWC43914.1 - 0.00086 18.4 0.0 0.0018 17.3 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase CMAS PF02353.15 EWC43914.1 - 0.022 13.8 0.0 0.1 11.6 0.0 1.9 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase MetW PF07021.7 EWC43914.1 - 0.022 14.1 0.0 0.035 13.4 0.0 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_32 PF13679.1 EWC43914.1 - 0.028 14.1 0.1 0.93 9.1 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain MTS PF05175.9 EWC43914.1 - 0.079 12.3 0.0 0.16 11.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain eIF2_C PF09173.6 EWC43916.1 - 2.1e-34 117.4 0.2 4.3e-34 116.4 0.1 1.6 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU PF00009.22 EWC43916.1 - 2e-21 76.2 0.0 1.1e-14 54.3 0.0 2.4 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.20 EWC43916.1 - 2.9e-12 46.5 0.6 5.8e-12 45.5 0.4 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 OTT_1508_deam PF14441.1 EWC43916.1 - 5.8e-07 29.3 0.0 1.2e-06 28.3 0.0 1.5 1 0 0 1 1 1 1 OTT_1508-like deaminase Iso_dh PF00180.15 EWC43917.1 - 7e-80 268.5 0.0 9.1e-80 268.2 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Erv26 PF04148.8 EWC43918.1 - 3.7e-76 255.2 0.2 4.2e-76 255.0 0.1 1.0 1 0 0 1 1 1 1 Transmembrane adaptor Erv26 QueT PF06177.6 EWC43918.1 - 0.016 15.1 3.0 0.032 14.2 2.1 1.5 1 0 0 1 1 1 0 QueT transporter Ribosomal_S13 PF00416.17 EWC43919.1 - 2e-27 95.7 0.6 2.9e-27 95.2 0.4 1.2 1 0 0 1 1 1 1 Ribosomal protein S13/S18 FbpA PF05833.6 EWC43919.1 - 0.00013 20.6 0.0 0.00024 19.7 0.0 1.3 1 1 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) HHH_3 PF12836.2 EWC43919.1 - 0.081 12.8 0.0 0.65 9.9 0.0 2.3 1 1 1 2 2 2 0 Helix-hairpin-helix motif Glyco_hydro_47 PF01532.15 EWC43921.1 - 2.2e-160 534.2 0.1 2.6e-160 533.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 PRA1 PF03208.14 EWC43923.1 - 8.6e-29 99.8 0.2 9.8e-29 99.6 0.1 1.1 1 0 0 1 1 1 1 PRA1 family protein Pox_P21 PF05313.7 EWC43923.1 - 0.47 9.6 2.7 4.4 6.5 0.1 2.1 2 0 0 2 2 2 0 Poxvirus P21 membrane protein DnaJ PF00226.26 EWC43924.1 - 1.3e-09 37.6 0.0 2.5e-09 36.7 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain HLH PF00010.21 EWC43926.1 - 1.9e-06 27.4 0.0 5.1e-06 26.0 0.0 1.8 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Ribosomal_L28e PF01778.12 EWC43926.1 - 0.23 11.8 2.5 0.16 12.3 0.4 1.7 2 0 0 2 2 2 0 Ribosomal L28e protein family APG17 PF04108.7 EWC43927.1 - 0.061 12.1 0.3 0.12 11.1 0.0 1.5 2 0 0 2 2 2 0 Autophagy protein Apg17 Ldh_1_N PF00056.18 EWC43928.1 - 1.9e-34 118.5 0.5 3.6e-34 117.6 0.4 1.5 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.13 EWC43928.1 - 6.7e-29 100.8 0.0 1.2e-28 99.9 0.0 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain OCD_Mu_crystall PF02423.10 EWC43928.1 - 3.4e-05 22.7 0.9 6.2e-05 21.9 0.7 1.3 1 0 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family ApbA PF02558.11 EWC43928.1 - 7.7e-05 22.1 0.7 0.00017 21.0 0.5 1.7 1 1 0 1 1 1 1 Ketopantoate reductase PanE/ApbA NAD_Gly3P_dh_N PF01210.18 EWC43928.1 - 0.00023 20.9 0.6 0.0016 18.2 0.0 2.5 3 0 0 3 3 3 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 3HCDH_N PF02737.13 EWC43928.1 - 0.00074 19.2 0.2 0.0015 18.2 0.2 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.9 EWC43928.1 - 0.0022 17.4 0.8 0.02 14.2 0.6 2.1 1 1 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Pyr_redox PF00070.22 EWC43928.1 - 0.0028 18.0 0.0 0.0053 17.1 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase ThiF PF00899.16 EWC43928.1 - 0.0062 16.3 1.2 0.015 15.1 0.4 1.9 1 1 1 2 2 2 1 ThiF family Lycopene_cycl PF05834.7 EWC43928.1 - 0.021 13.7 0.1 0.045 12.6 0.1 1.6 1 0 0 1 1 1 0 Lycopene cyclase protein TrkA_N PF02254.13 EWC43928.1 - 0.031 14.2 0.3 0.059 13.3 0.2 1.5 1 0 0 1 1 1 0 TrkA-N domain DAO PF01266.19 EWC43928.1 - 0.037 12.9 0.3 0.055 12.3 0.2 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase F420_oxidored PF03807.12 EWC43928.1 - 0.079 13.4 0.2 0.27 11.6 0.2 2.0 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent NAD_binding_9 PF13454.1 EWC43928.1 - 0.087 12.5 0.0 0.16 11.7 0.0 1.6 1 0 0 1 1 1 0 FAD-NAD(P)-binding MFS_1 PF07690.11 EWC43929.1 - 1.6e-29 102.7 23.9 2.5e-29 102.1 16.6 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily OAD_gamma PF04277.8 EWC43929.1 - 0.037 14.3 0.0 1.4 9.3 0.0 2.5 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain Acyl_transf_3 PF01757.17 EWC43929.1 - 2.9 6.6 29.4 0.12 11.1 2.5 2.6 2 1 1 3 3 3 0 Acyltransferase family YtpI PF14007.1 EWC43929.1 - 6.8 6.6 8.8 12 5.9 0.2 3.1 3 0 0 3 3 3 0 YtpI-like protein DUF3372 PF11852.3 EWC43930.1 - 0.027 13.6 0.0 0.067 12.3 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3372) E2R135 PF11570.3 EWC43931.1 - 0.012 15.7 4.8 0.019 15.0 3.3 1.3 1 0 0 1 1 1 0 Coiled-coil receptor-binding R-domain of colicin E2 DUF883 PF05957.8 EWC43931.1 - 0.13 12.6 2.7 0.17 12.3 1.9 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) Hc1 PF07432.8 EWC43931.1 - 0.17 12.0 6.3 0.19 11.8 4.3 1.0 1 0 0 1 1 1 0 Histone H1-like protein Hc1 Abhydrolase_6 PF12697.2 EWC43932.1 - 0.0014 18.5 0.0 0.002 18.0 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF676 PF05057.9 EWC43932.1 - 0.16 11.2 0.0 0.39 9.9 0.0 1.7 1 1 0 1 1 1 0 Putative serine esterase (DUF676) Proteasome PF00227.21 EWC43933.1 - 1.9e-50 170.8 0.0 6.2e-50 169.1 0.0 1.7 2 0 0 2 2 2 1 Proteasome subunit Proteasome_A_N PF10584.4 EWC43933.1 - 1.5e-12 46.5 0.0 3.1e-12 45.5 0.0 1.6 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature HSA PF07529.8 EWC43934.1 - 2.9e-15 55.8 2.9 2.9e-15 55.8 2.0 4.1 3 0 0 3 3 3 1 HSA Myb_DNA-bind_6 PF13921.1 EWC43934.1 - 1.2e-07 31.7 1.8 2.6e-07 30.6 1.3 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 EWC43934.1 - 1.8e-05 24.7 0.5 4.4e-05 23.4 0.3 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain WD40 PF00400.27 EWC43935.1 - 4.3e-09 35.9 0.0 3.3e-05 23.6 0.0 3.5 4 0 0 4 4 4 2 WD domain, G-beta repeat CDC45 PF02724.9 EWC43935.1 - 0.59 8.1 3.2 0.88 7.5 2.2 1.2 1 0 0 1 1 1 0 CDC45-like protein Glyco_hydro_61 PF03443.9 EWC43936.1 - 4.2e-28 98.6 0.3 6.9e-27 94.6 0.0 2.1 2 0 0 2 2 2 1 Glycosyl hydrolase family 61 ABC_tran PF00005.22 EWC43937.1 - 7.8e-55 184.9 0.0 5.6e-29 101.1 0.0 2.4 2 0 0 2 2 2 2 ABC transporter ABC2_membrane_3 PF12698.2 EWC43937.1 - 4.7e-26 91.6 46.3 4.6e-16 58.7 12.7 2.6 3 0 0 3 3 2 2 ABC-2 family transporter protein AAA_21 PF13304.1 EWC43937.1 - 3.6e-21 76.4 0.0 8.6e-07 29.1 0.0 4.6 4 0 0 4 4 4 4 AAA domain SMC_N PF02463.14 EWC43937.1 - 5.9e-08 32.2 1.4 0.0069 15.6 0.0 4.1 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 EWC43937.1 - 3e-07 30.9 0.2 0.03 14.6 0.0 2.6 2 0 0 2 2 2 2 AAA domain DUF258 PF03193.11 EWC43937.1 - 6.3e-07 28.7 0.9 0.00046 19.3 0.1 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_29 PF13555.1 EWC43937.1 - 6.3e-07 28.8 0.7 0.0033 16.9 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.1 EWC43937.1 - 1e-05 25.6 0.1 0.22 11.5 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA_30 PF13604.1 EWC43937.1 - 0.0011 18.5 0.6 0.96 8.9 0.0 2.9 3 0 0 3 3 3 2 AAA domain SRP54 PF00448.17 EWC43937.1 - 0.0029 17.0 0.1 0.5 9.7 0.0 2.4 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_10 PF12846.2 EWC43937.1 - 0.004 16.6 0.9 0.43 9.9 0.0 2.4 2 0 0 2 2 2 1 AAA-like domain ABC2_membrane_5 PF13346.1 EWC43937.1 - 0.0042 16.3 14.5 0.0042 16.3 10.1 3.2 2 1 0 2 2 1 1 ABC-2 family transporter protein AAA_19 PF13245.1 EWC43937.1 - 0.0046 16.6 1.2 2.3 8.0 0.2 2.8 2 0 0 2 2 2 1 Part of AAA domain T2SE PF00437.15 EWC43937.1 - 0.0081 15.0 0.1 1.2 7.9 0.0 2.8 3 0 0 3 3 3 1 Type II/IV secretion system protein AAA_22 PF13401.1 EWC43937.1 - 0.0082 16.2 1.4 2.9 8.0 0.0 3.1 2 2 0 2 2 2 1 AAA domain AAA_33 PF13671.1 EWC43937.1 - 0.019 14.8 0.5 0.66 9.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.10 EWC43937.1 - 0.025 13.2 0.1 1.4 7.4 0.0 2.2 2 0 0 2 2 2 0 Rad17 cell cycle checkpoint protein Zeta_toxin PF06414.7 EWC43937.1 - 0.028 13.5 0.0 1.1 8.3 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin IstB_IS21 PF01695.12 EWC43937.1 - 0.035 13.5 3.9 13 5.1 0.0 4.5 5 0 0 5 5 5 0 IstB-like ATP binding protein MutS_V PF00488.16 EWC43937.1 - 0.037 13.4 0.1 5.8 6.2 0.0 2.6 2 0 0 2 2 2 0 MutS domain V AAA PF00004.24 EWC43937.1 - 0.053 13.7 2.3 12 6.1 0.0 2.9 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) UPF0079 PF02367.12 EWC43937.1 - 0.094 12.3 0.3 0.65 9.6 0.1 2.2 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 Aldo_ket_red PF00248.16 EWC43937.1 - 0.11 11.3 0.0 0.3 9.8 0.0 1.7 1 0 0 1 1 1 0 Aldo/keto reductase family AAA_24 PF13479.1 EWC43937.1 - 0.11 12.1 0.0 7.2 6.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.17 EWC43937.1 - 0.29 9.9 0.7 3.2 6.5 0.1 2.3 2 0 0 2 2 2 0 NB-ARC domain AAA_15 PF13175.1 EWC43937.1 - 0.4 9.6 0.0 48 2.8 0.0 3.0 3 0 0 3 3 3 0 AAA ATPase domain ABC2_membrane_4 PF12730.2 EWC43937.1 - 0.41 9.7 58.7 0.28 10.3 17.2 3.4 2 2 0 2 2 2 0 ABC-2 family transporter protein AAA_28 PF13521.1 EWC43937.1 - 0.41 10.5 2.1 20 5.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain NACHT PF05729.7 EWC43937.1 - 0.78 9.3 4.3 7.6 6.1 0.5 2.7 3 0 0 3 3 2 0 NACHT domain Tyrosinase PF00264.15 EWC43938.1 - 3.2e-54 184.4 2.6 3.2e-54 184.4 1.8 2.2 2 1 0 2 2 2 1 Common central domain of tyrosinase TFIIA PF03153.8 EWC43938.1 - 0.37 10.6 6.4 0.7 9.7 4.4 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Med3 PF11593.3 EWC43938.1 - 0.99 8.5 24.0 2.3 7.3 16.6 1.6 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DUF605 PF04652.11 EWC43938.1 - 2 7.7 16.6 3.2 7.0 11.5 1.3 1 0 0 1 1 1 0 Vta1 like Macoilin PF09726.4 EWC43938.1 - 4.5 5.4 15.5 6.2 4.9 10.7 1.1 1 0 0 1 1 1 0 Transmembrane protein Podoplanin PF05808.6 EWC43941.1 - 0.096 12.2 0.1 0.16 11.4 0.0 1.3 1 0 0 1 1 1 0 Podoplanin Bacteriocin_IIc PF10439.4 EWC43941.1 - 2.1 8.5 9.1 0.094 12.8 1.3 2.4 3 0 0 3 3 3 0 Bacteriocin class II with double-glycine leader peptide AA_permease_2 PF13520.1 EWC43942.1 - 2.9e-80 269.8 28.0 3.7e-80 269.5 19.4 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EWC43942.1 - 8e-18 64.0 27.2 1.1e-17 63.6 18.8 1.2 1 0 0 1 1 1 1 Amino acid permease DUF2611 PF11022.3 EWC43942.1 - 0.18 11.9 0.2 2.3 8.3 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2611) PTR2 PF00854.16 EWC43945.1 - 1.3e-49 168.9 19.2 3.8e-48 164.1 13.3 2.3 1 1 0 1 1 1 1 POT family CorA PF01544.13 EWC43946.1 - 3.7e-09 36.0 0.4 5.1e-09 35.5 0.3 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein DUF3955 PF13127.1 EWC43947.1 - 0.031 13.8 0.2 0.054 13.0 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3955) DUF349 PF03993.7 EWC43947.1 - 0.04 14.0 0.1 0.072 13.2 0.1 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF349) Pkinase PF00069.20 EWC43948.1 - 1.9e-29 102.6 0.0 4.1e-29 101.5 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC43948.1 - 3.3e-09 36.2 0.1 2.2e-07 30.2 0.0 2.9 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 EWC43948.1 - 0.0023 17.7 0.4 0.34 10.6 0.0 2.3 2 0 0 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.9 EWC43948.1 - 0.015 14.4 0.0 0.034 13.2 0.0 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 EWC43948.1 - 0.042 12.8 0.0 1.1 8.2 0.0 2.5 2 0 0 2 2 2 0 Kinase-like Zn_protease PF05618.6 EWC43948.1 - 0.051 13.2 0.0 0.61 9.7 0.0 2.1 2 0 0 2 2 2 0 Putative ATP-dependant zinc protease P12 PF12669.2 EWC43949.1 - 0.025 14.7 0.1 0.036 14.2 0.1 1.2 1 0 0 1 1 1 0 Virus attachment protein p12 family EphA2_TM PF14575.1 EWC43949.1 - 0.069 13.5 0.0 0.094 13.1 0.0 1.3 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF2663 PF10864.3 EWC43949.1 - 0.085 13.0 0.0 0.11 12.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2663) Sarcoglycan_2 PF05510.8 EWC43949.1 - 0.091 11.0 0.0 0.096 10.9 0.0 1.0 1 0 0 1 1 1 0 Sarcoglycan alpha/epsilon Cytochrom_B_N PF00033.14 EWC43949.1 - 0.12 11.7 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 Cytochrome b(N-terminal)/b6/petB SKG6 PF08693.5 EWC43949.1 - 0.23 10.8 4.8 0.45 9.8 3.3 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Rab5ip PF07019.7 EWC43950.1 - 0.076 13.1 0.2 0.094 12.8 0.1 1.2 1 0 0 1 1 1 0 Rab5-interacting protein (Rab5ip) DUF2627 PF11118.3 EWC43950.1 - 0.1 12.6 0.3 0.15 12.1 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2627) PhyH PF05721.8 EWC43951.1 - 7.4e-10 39.2 0.0 1.2e-09 38.4 0.0 1.3 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) CFEM PF05730.6 EWC43952.1 - 7.3e-12 44.9 9.0 7.3e-12 44.9 6.2 1.6 2 0 0 2 2 2 1 CFEM domain DUF2318 PF10080.4 EWC43952.1 - 3.7 7.3 6.1 20 5.0 3.5 2.0 1 1 1 2 2 2 0 Predicted membrane protein (DUF2318) AAA_assoc PF14363.1 EWC43954.1 - 0.06 13.4 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 Domain associated at C-terminal with AAA FMN_red PF03358.10 EWC43955.1 - 6.3e-23 80.9 0.0 8.4e-23 80.5 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.12 EWC43955.1 - 0.00052 19.5 0.0 0.00075 19.0 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin-like fold F-box-like PF12937.2 EWC43956.1 - 4.7e-05 23.0 1.1 0.00021 20.9 0.7 2.2 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EWC43956.1 - 0.0017 17.9 0.0 0.0055 16.3 0.0 1.8 1 0 0 1 1 1 1 F-box domain Aldo_ket_red PF00248.16 EWC43957.1 - 3.3e-48 163.9 0.0 4.2e-48 163.6 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family CoA_binding_2 PF13380.1 EWC43957.1 - 0.053 13.6 0.1 33 4.6 0.0 3.2 3 0 0 3 3 3 0 CoA binding domain WD40 PF00400.27 EWC43959.1 - 4.9e-46 153.0 22.8 3e-10 39.5 0.4 6.2 6 0 0 6 6 6 6 WD domain, G-beta repeat YmzC PF14157.1 EWC43959.1 - 0.12 12.2 0.0 28 4.6 0.0 3.6 4 0 0 4 4 4 0 YmzC-like protein IKI3 PF04762.7 EWC43959.1 - 0.14 9.8 3.5 0.9 7.2 0.1 2.0 2 0 0 2 2 2 0 IKI3 family Sugar_tr PF00083.19 EWC43960.1 - 1.5e-28 99.5 37.3 1.1e-25 90.1 25.9 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EWC43960.1 - 9.8e-19 67.2 41.6 1.1e-11 44.1 15.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily RNB PF00773.14 EWC43961.1 - 3.8e-82 276.1 0.1 6.6e-82 275.3 0.1 1.3 1 0 0 1 1 1 1 RNB domain PIN_4 PF13638.1 EWC43961.1 - 4.7e-11 42.9 0.1 1.3e-10 41.5 0.1 1.7 1 0 0 1 1 1 1 PIN domain OB_RNB PF08206.6 EWC43961.1 - 0.013 14.9 0.1 0.034 13.6 0.0 1.7 1 0 0 1 1 1 0 Ribonuclease B OB domain DUF4612 PF15389.1 EWC43961.1 - 0.037 14.6 0.1 0.1 13.2 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4612) CRC_subunit PF08624.5 EWC43962.1 - 8.6e-56 187.7 0.0 1.3e-55 187.1 0.0 1.3 1 0 0 1 1 1 1 Chromatin remodelling complex Rsc7/Swp82 subunit zf-C2H2_3 PF13878.1 EWC43963.1 - 0.089 12.3 0.2 0.21 11.1 0.1 1.5 1 0 0 1 1 1 0 zinc-finger of acetyl-transferase ESCO UPF0029 PF01205.14 EWC43965.1 - 6.7e-19 67.5 0.6 7.1e-18 64.2 0.0 2.6 3 1 1 4 4 4 1 Uncharacterized protein family UPF0029 DUF2693 PF10902.3 EWC43965.1 - 0.16 11.9 1.6 2 8.3 0.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2693) HAUS6_N PF14661.1 EWC43965.1 - 2.2 7.6 5.4 1.4 8.1 2.0 1.8 2 1 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus GN3L_Grn1 PF08701.6 EWC43966.1 - 9.6e-26 89.5 14.0 1.9e-25 88.5 9.7 1.5 1 0 0 1 1 1 1 GNL3L/Grn1 putative GTPase MMR_HSR1 PF01926.18 EWC43966.1 - 4.2e-17 62.1 0.0 4.1e-13 49.3 0.0 2.4 2 0 0 2 2 2 2 50S ribosome-binding GTPase GTP_EFTU PF00009.22 EWC43966.1 - 8.9e-06 25.2 0.0 0.0069 15.8 0.0 2.5 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain FeoB_N PF02421.13 EWC43966.1 - 4.7e-05 22.7 0.3 0.00026 20.3 0.1 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B DUF258 PF03193.11 EWC43966.1 - 5.5e-05 22.3 0.1 0.00012 21.3 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Dynamin_N PF00350.18 EWC43966.1 - 0.00015 21.5 1.2 0.081 12.7 0.1 3.5 2 1 1 3 3 3 1 Dynamin family AIG1 PF04548.11 EWC43966.1 - 0.0039 16.3 0.0 0.04 13.0 0.0 2.2 2 0 0 2 2 2 1 AIG1 family Gtr1_RagA PF04670.7 EWC43966.1 - 0.0069 15.5 0.0 2.9 6.9 0.0 2.2 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Miro PF08477.8 EWC43966.1 - 0.016 15.7 0.1 0.79 10.2 0.0 2.9 2 0 0 2 2 2 0 Miro-like protein ArgK PF03308.11 EWC43966.1 - 0.041 12.6 0.1 0.077 11.7 0.1 1.4 1 0 0 1 1 1 0 ArgK protein Torsin PF06309.6 EWC43966.1 - 0.075 12.9 0.1 0.14 12.0 0.1 1.3 1 0 0 1 1 1 0 Torsin DUF1664 PF07889.7 EWC43967.1 - 0.0058 16.4 1.9 0.0066 16.2 0.1 1.9 2 1 0 2 2 2 1 Protein of unknown function (DUF1664) Dor1 PF04124.7 EWC43967.1 - 0.01 14.3 2.5 0.013 14.0 1.7 1.1 1 0 0 1 1 1 0 Dor1-like family CysG_dimeriser PF10414.4 EWC43967.1 - 0.019 14.4 0.7 1.3 8.5 0.1 2.4 2 0 0 2 2 2 0 Sirohaem synthase dimerisation region T2SF PF00482.18 EWC43967.1 - 0.031 14.1 1.2 0.074 12.9 0.8 1.8 1 1 0 1 1 1 0 Type II secretion system (T2SS), protein F Tropomyosin_1 PF12718.2 EWC43967.1 - 0.064 13.1 11.0 2.6 7.9 5.2 2.1 1 1 1 2 2 2 0 Tropomyosin like MutL_C PF08676.6 EWC43967.1 - 0.12 12.0 1.0 0.23 11.0 0.7 1.6 1 1 0 1 1 1 0 MutL C terminal dimerisation domain GvpL_GvpF PF06386.6 EWC43967.1 - 0.32 10.5 2.7 0.48 9.9 1.9 1.3 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF Synaptobrevin PF00957.16 EWC43967.1 - 1.1 8.8 4.5 4.3 7.0 0.1 3.0 1 1 1 3 3 3 0 Synaptobrevin Drc1-Sld2 PF11719.3 EWC43967.1 - 2 7.4 6.2 2.4 7.1 4.3 1.1 1 0 0 1 1 1 0 DNA replication and checkpoint protein OmpH PF03938.9 EWC43967.1 - 2 8.3 4.3 3.6 7.5 3.0 1.5 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) GAS PF13851.1 EWC43967.1 - 2.7 7.1 10.3 10 5.2 7.2 1.9 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding Homeobox PF00046.24 EWC43968.1 - 4.8e-16 58.1 2.9 1.5e-15 56.5 2.0 1.9 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.6 EWC43968.1 - 0.023 14.4 0.7 0.08 12.6 0.5 2.0 1 0 0 1 1 1 0 Homeobox KN domain HTH_24 PF13412.1 EWC43968.1 - 0.15 11.4 0.0 0.26 10.6 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Ank_2 PF12796.2 EWC43969.1 - 1.4e-43 147.0 3.8 7.2e-22 77.5 0.2 3.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 EWC43969.1 - 7.8e-38 126.4 4.4 3.1e-08 33.0 0.1 6.2 6 0 0 6 6 6 6 Ankyrin repeat Ank_3 PF13606.1 EWC43969.1 - 2.1e-33 110.9 0.5 6.7e-05 22.7 0.0 6.6 7 0 0 7 7 7 6 Ankyrin repeat Ank_4 PF13637.1 EWC43969.1 - 2.3e-32 110.7 2.1 2.9e-08 34.0 0.0 4.4 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.1 EWC43969.1 - 2.7e-30 103.7 2.1 2.7e-10 40.1 0.1 5.1 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Shal-type PF11601.3 EWC43969.1 - 0.024 14.1 0.0 0.043 13.3 0.0 1.4 1 0 0 1 1 1 0 Shal-type voltage-gated potassium channels Shigella_OspC PF06128.6 EWC43969.1 - 0.057 12.9 0.5 11 5.3 0.1 2.4 2 1 1 3 3 3 0 Shigella flexneri OspC protein Prefoldin_2 PF01920.15 EWC43970.1 - 1.9e-19 69.3 6.3 2.1e-19 69.2 4.0 1.3 1 1 0 1 1 1 1 Prefoldin subunit CSTF_C PF14304.1 EWC43970.1 - 0.2 10.9 4.7 0.25 10.6 0.0 2.3 2 0 0 2 2 2 0 Transcription termination and cleavage factor C-terminal RasGAP_C PF03836.10 EWC43970.1 - 0.28 10.8 6.2 0.29 10.8 0.5 2.1 2 0 0 2 2 2 0 RasGAP C-terminus TPR_MLP1_2 PF07926.7 EWC43970.1 - 0.38 10.4 6.1 0.77 9.5 4.2 1.5 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein DUF948 PF06103.6 EWC43970.1 - 0.53 10.1 2.7 2.2 8.1 0.1 2.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Tropomyosin_1 PF12718.2 EWC43970.1 - 0.54 10.0 5.8 0.4 10.5 0.6 2.1 2 0 0 2 2 2 0 Tropomyosin like ADIP PF11559.3 EWC43970.1 - 3.8 7.4 10.7 1.4 8.8 0.7 2.1 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Gryzun PF07919.7 EWC43972.1 - 9.7e-75 251.9 0.0 1.4e-74 251.4 0.0 1.1 1 0 0 1 1 1 1 Gryzun, putative trafficking through Golgi Foie-gras_1 PF11817.3 EWC43972.1 - 3.3e-36 125.0 1.4 1.2e-34 119.8 0.4 2.2 2 0 0 2 2 2 1 Foie gras liver health family 1 TPR_12 PF13424.1 EWC43972.1 - 0.17 11.8 0.1 12 5.8 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat Gryzun-like PF12742.2 EWC43972.1 - 0.19 11.5 0.1 0.42 10.4 0.0 1.5 1 0 0 1 1 1 0 Gryzun, putative Golgi trafficking RXT2_N PF08595.6 EWC43973.1 - 8.1e-34 116.5 0.1 8.1e-34 116.5 0.0 2.3 2 0 0 2 2 2 1 RXT2-like, N-terminal Tubulin PF00091.20 EWC43974.1 - 7e-70 235.2 0.0 1.2e-69 234.4 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.12 EWC43974.1 - 2.6e-49 166.4 0.1 4.3e-49 165.7 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.4 EWC43974.1 - 2.2e-05 24.4 0.0 4.7e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.1 EWC43974.1 - 0.0052 16.2 0.0 0.0092 15.4 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain Arginosuc_synth PF00764.14 EWC43975.1 - 2.3e-156 520.7 0.0 2.7e-156 520.5 0.0 1.0 1 0 0 1 1 1 1 Arginosuccinate synthase Asn_synthase PF00733.16 EWC43975.1 - 0.0012 18.4 0.0 0.0016 17.9 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase QueC PF06508.8 EWC43975.1 - 0.0015 17.8 0.0 0.0027 17.0 0.0 1.4 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.11 EWC43975.1 - 0.012 14.2 0.0 0.019 13.5 0.0 1.3 1 0 0 1 1 1 0 tRNA methyl transferase Apq12 PF12716.2 EWC43976.1 - 0.024 14.3 8.4 0.044 13.4 5.8 1.4 1 0 0 1 1 1 0 Nuclear pore assembly and biogenesis DUF2456 PF10445.4 EWC43976.1 - 0.066 13.1 5.6 0.1 12.5 2.7 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2456) DUF1129 PF06570.6 EWC43976.1 - 1.7 7.8 5.3 2.5 7.3 3.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) DUF3270 PF11674.3 EWC43976.1 - 3.8 7.5 4.8 6.5 6.8 3.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3270) TMF_TATA_bd PF12325.3 EWC43977.1 - 2.3e-36 124.1 9.9 2.3e-36 124.1 6.9 6.6 3 2 4 7 7 7 1 TATA element modulatory factor 1 TATA binding TMF_DNA_bd PF12329.3 EWC43977.1 - 3.1e-15 55.7 19.5 3.1e-15 55.7 13.5 8.4 7 1 1 8 8 8 2 TATA element modulatory factor 1 DNA binding MbeD_MobD PF04899.7 EWC43977.1 - 6.1 6.8 15.4 0.034 14.0 1.0 4.1 5 0 0 5 5 5 0 MbeD/MobD like Fungal_trans_2 PF11951.3 EWC43977.1 - 8.4 4.8 6.9 0.52 8.8 0.3 2.3 2 1 0 2 2 2 0 Fungal specific transcription factor domain Ceramidase PF05875.7 EWC43978.1 - 2e-86 289.4 18.4 2.3e-86 289.2 12.8 1.0 1 0 0 1 1 1 1 Ceramidase TauE PF01925.14 EWC43978.1 - 0.00031 20.2 1.8 0.00031 20.2 1.2 1.4 2 0 0 2 2 2 1 Sulfite exporter TauE/SafE DUF3397 PF11877.3 EWC43978.1 - 0.027 14.4 3.6 0.047 13.6 2.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3397) Peptidase_M28 PF04389.12 EWC43980.1 - 1.9e-28 99.4 0.1 3.1e-28 98.7 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.23 EWC43980.1 - 1.7e-05 24.4 0.1 2.5e-05 23.8 0.1 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 PEMT PF04191.8 EWC43982.1 - 7.2e-31 106.4 2.5 7.2e-31 106.4 1.7 1.7 2 0 0 2 2 2 1 Phospholipid methyltransferase WD40 PF00400.27 EWC43983.1 - 1.2e-48 161.2 5.5 3.7e-08 32.9 0.1 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat Prefoldin PF02996.12 EWC43984.1 - 3.8e-29 100.7 0.6 5.2e-29 100.3 0.2 1.3 1 1 0 1 1 1 1 Prefoldin subunit Fib_alpha PF08702.5 EWC43984.1 - 0.013 15.6 0.3 2.7 8.1 0.1 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF1192 PF06698.6 EWC43984.1 - 0.02 14.6 0.2 0.044 13.6 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) Sec2p PF06428.6 EWC43984.1 - 0.032 14.0 0.6 0.1 12.4 0.1 2.0 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p Prefoldin_2 PF01920.15 EWC43984.1 - 0.033 13.9 3.1 0.63 9.8 0.2 2.1 2 0 0 2 2 2 0 Prefoldin subunit Cep57_MT_bd PF06657.8 EWC43984.1 - 0.053 13.4 0.4 0.11 12.5 0.3 1.5 1 0 0 1 1 1 0 Centrosome microtubule-binding domain of Cep57 Prefoldin_3 PF13758.1 EWC43984.1 - 0.063 13.0 0.2 0.2 11.4 0.1 1.9 1 1 0 1 1 1 0 Prefoldin subunit DUF1664 PF07889.7 EWC43984.1 - 0.16 11.7 2.3 2.4 7.9 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) BLOC1_2 PF10046.4 EWC43984.1 - 0.17 12.0 2.3 7.1 6.8 0.1 2.3 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 KH_1 PF00013.24 EWC43985.1 - 5.7e-05 22.6 0.0 0.01 15.4 0.0 2.6 2 0 0 2 2 2 2 KH domain AAA PF00004.24 EWC43986.1 - 1.6e-13 51.0 0.0 2.9e-13 50.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 EWC43986.1 - 5.6e-12 46.0 0.0 6e-11 42.6 0.0 2.4 1 1 0 1 1 1 1 AAA ATPase domain BAH PF01426.13 EWC43986.1 - 3.9e-07 29.8 0.0 9.6e-07 28.5 0.0 1.6 1 0 0 1 1 1 1 BAH domain AAA_22 PF13401.1 EWC43986.1 - 3.4e-06 27.2 0.0 1.5e-05 25.1 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 EWC43986.1 - 0.00025 20.7 0.1 0.00089 18.9 0.1 1.9 1 0 0 1 1 1 1 Part of AAA domain AAA_17 PF13207.1 EWC43986.1 - 0.0054 17.5 0.1 0.11 13.2 0.0 2.9 3 0 0 3 3 3 1 AAA domain PIF1 PF05970.9 EWC43986.1 - 0.031 13.2 0.0 0.051 12.5 0.0 1.2 1 0 0 1 1 1 0 PIF1-like helicase AAA_11 PF13086.1 EWC43986.1 - 0.042 13.4 0.0 0.088 12.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain Arch_ATPase PF01637.13 EWC43986.1 - 0.061 13.0 0.0 0.49 10.0 0.0 2.1 1 1 0 1 1 1 0 Archaeal ATPase AAA_18 PF13238.1 EWC43986.1 - 0.063 13.5 0.0 0.15 12.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain KAP_NTPase PF07693.9 EWC43986.1 - 0.085 11.8 0.0 2 7.2 0.0 2.3 1 1 1 2 2 2 0 KAP family P-loop domain RNA_helicase PF00910.17 EWC43986.1 - 0.09 12.9 0.0 0.37 10.9 0.0 2.0 2 0 0 2 2 2 0 RNA helicase AAA_28 PF13521.1 EWC43986.1 - 0.093 12.6 0.0 0.21 11.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain Baculo_11_kDa PF06143.6 EWC43986.1 - 0.22 10.9 0.0 1.2 8.4 0.0 2.1 2 0 0 2 2 2 0 Baculovirus 11 kDa family Pol_alpha_B_N PF08418.5 EWC43986.1 - 2.8 7.4 9.1 0.3 10.5 2.2 2.0 2 0 0 2 2 2 0 DNA polymerase alpha subunit B N-terminal 4HBT PF03061.17 EWC43987.1 - 5.1e-06 26.5 0.0 1.2e-05 25.3 0.0 1.6 1 0 0 1 1 1 1 Thioesterase superfamily Isochorismatase PF00857.15 EWC43988.1 - 2.3e-19 69.9 0.0 3.5e-19 69.3 0.0 1.2 1 0 0 1 1 1 1 Isochorismatase family DUF3325 PF11804.3 EWC43988.1 - 0.16 11.9 0.8 0.41 10.5 0.2 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF3325) E1-E2_ATPase PF00122.15 EWC43989.1 - 8.1e-53 178.8 4.3 8.1e-53 178.8 3.0 2.4 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 EWC43989.1 - 7.7e-43 146.1 8.3 7.7e-43 146.1 5.8 2.7 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 EWC43989.1 - 4e-27 96.0 0.0 1.4e-26 94.2 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 EWC43989.1 - 1.6e-16 60.0 0.0 3.2e-16 59.0 0.0 1.6 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 EWC43989.1 - 6.7e-12 45.9 0.0 1.9e-11 44.4 0.0 1.8 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 EWC43989.1 - 1.9e-06 27.2 1.7 2.7e-06 26.7 0.1 2.1 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.7 EWC43989.1 - 7.4e-06 25.7 0.6 0.00013 21.6 0.4 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase tRNA-synt_2 PF00152.15 EWC43990.1 - 1.1e-79 267.6 0.1 2.1e-79 266.7 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) DUF2156 PF09924.4 EWC43990.1 - 6.8e-18 64.5 0.0 9.6e-18 64.0 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2156) tRNA_anti-codon PF01336.20 EWC43990.1 - 0.00075 19.3 0.1 0.0014 18.3 0.1 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.15 EWC43990.1 - 0.013 14.7 0.5 1.3 8.1 0.0 2.3 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) Ion_trans PF00520.26 EWC43991.1 - 5.5e-105 348.9 75.6 3.7e-31 107.9 6.5 5.0 4 1 0 4 4 4 4 Ion transport protein PAP_RNA-bind PF04926.10 EWC43991.1 - 0.045 13.2 0.0 1.3 8.5 0.0 2.2 2 0 0 2 2 2 0 Poly(A) polymerase predicted RNA binding domain SET PF00856.23 EWC43993.1 - 4.3e-24 85.6 0.1 3.6e-23 82.6 0.0 2.2 2 0 0 2 2 2 1 SET domain Pre-SET PF05033.11 EWC43993.1 - 1e-15 57.8 4.0 1e-15 57.8 2.8 2.0 2 0 0 2 2 2 1 Pre-SET motif Chromo PF00385.19 EWC43993.1 - 5.2e-13 48.4 1.7 9.1e-13 47.6 1.1 1.4 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Tudor-knot PF11717.3 EWC43993.1 - 0.026 14.2 0.1 0.056 13.1 0.1 1.6 1 0 0 1 1 1 0 RNA binding activity-knot of a chromodomain AT_hook PF02178.14 EWC43993.1 - 0.054 13.1 17.4 0.12 12.0 2.8 3.0 3 0 0 3 3 3 0 AT hook motif Nop52 PF05997.7 EWC43994.1 - 3.5e-68 229.2 0.0 4.3e-68 228.9 0.0 1.0 1 0 0 1 1 1 1 Nucleolar protein,Nop52 AP_endonuc_2 PF01261.19 EWC43994.1 - 0.05 12.8 0.0 0.12 11.6 0.0 1.5 2 0 0 2 2 2 0 Xylose isomerase-like TIM barrel DAGK_cat PF00781.19 EWC43995.1 - 1.7e-23 82.4 0.0 2.7e-23 81.8 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Adaptin_N PF01602.15 EWC43996.1 - 8.7e-94 314.7 4.0 1.4e-93 314.0 2.8 1.2 1 0 0 1 1 1 1 Adaptin N terminal region Coatamer_beta_C PF07718.7 EWC43996.1 - 3.6e-62 208.1 0.8 8.6e-62 206.9 0.5 1.7 1 0 0 1 1 1 1 Coatomer beta C-terminal region Coatomer_b_Cpla PF14806.1 EWC43996.1 - 2.4e-60 201.9 0.0 6.5e-60 200.5 0.0 1.7 1 0 0 1 1 1 1 Coatomer beta subunit appendage platform HEAT_2 PF13646.1 EWC43996.1 - 2.4e-14 53.3 0.9 6.4e-07 29.5 0.0 4.2 2 1 2 4 4 4 3 HEAT repeats Cnd1 PF12717.2 EWC43996.1 - 3.1e-05 23.9 10.7 4.6e-05 23.3 0.3 3.4 2 1 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.17 EWC43996.1 - 0.00044 20.0 3.0 0.12 12.4 0.0 4.7 6 0 0 6 6 6 1 HEAT repeat HEAT_EZ PF13513.1 EWC43996.1 - 0.0022 18.4 2.2 0.19 12.2 0.0 4.5 3 2 2 5 5 5 2 HEAT-like repeat Mago_nashi PF02792.9 EWC43997.1 - 1.7e-76 254.7 0.3 1.9e-76 254.5 0.2 1.0 1 0 0 1 1 1 1 Mago nashi protein Phage_portal_2 PF05136.8 EWC43997.1 - 0.12 10.8 0.0 0.16 10.4 0.0 1.1 1 0 0 1 1 1 0 Phage portal protein, lambda family Vac_ImportDeg PF09783.4 EWC43998.1 - 1.7e-64 216.5 0.5 2.4e-64 216.0 0.4 1.1 1 0 0 1 1 1 1 Vacuolar import and degradation protein Methyltransf_4 PF02390.12 EWC43999.1 - 2.5e-58 196.3 0.0 3.2e-58 196.0 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_18 PF12847.2 EWC43999.1 - 1.3e-05 25.7 0.0 2.4e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EWC43999.1 - 0.00083 19.7 0.0 0.0081 16.6 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_26 PF13659.1 EWC43999.1 - 0.0019 18.2 0.0 0.0034 17.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EWC43999.1 - 0.015 14.7 0.0 0.069 12.5 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_31 PF13847.1 EWC43999.1 - 0.016 14.7 0.0 0.11 12.1 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase domain FmrO PF07091.6 EWC43999.1 - 0.023 13.7 0.0 0.043 12.8 0.0 1.4 1 0 0 1 1 1 0 Ribosomal RNA methyltransferase (FmrO) Methyltransf_25 PF13649.1 EWC43999.1 - 0.026 14.8 0.0 0.055 13.8 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.1 EWC43999.1 - 0.052 13.2 0.0 0.3 10.7 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.7 EWC43999.1 - 0.052 14.0 0.0 0.65 10.5 0.0 2.4 1 1 0 1 1 1 0 Methyltransferase domain CMAS PF02353.15 EWC43999.1 - 0.1 11.6 0.0 0.14 11.2 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_32 PF13679.1 EWC43999.1 - 0.13 11.9 0.0 0.26 10.9 0.0 1.5 2 0 0 2 2 2 0 Methyltransferase domain PXA PF02194.10 EWC44000.1 - 8e-47 159.2 0.3 2e-46 157.9 0.2 1.7 1 0 0 1 1 1 1 PXA domain Nexin_C PF08628.7 EWC44000.1 - 2.7e-24 85.4 0.1 9.8e-24 83.6 0.0 2.1 1 0 0 1 1 1 1 Sorting nexin C terminal PX PF00787.19 EWC44000.1 - 1.1e-20 73.5 0.1 3.7e-20 71.8 0.0 2.0 1 0 0 1 1 1 1 PX domain RGS PF00615.14 EWC44000.1 - 1.6e-12 47.5 0.0 6.4e-12 45.6 0.0 2.1 1 0 0 1 1 1 1 Regulator of G protein signaling domain ABC_tran PF00005.22 EWC44001.1 - 1.3e-47 161.5 0.2 5e-23 81.9 0.0 3.0 3 0 0 3 3 2 2 ABC transporter ABC_tran_2 PF12848.2 EWC44001.1 - 1e-20 73.3 2.5 1e-20 73.3 1.7 2.8 3 0 0 3 3 2 1 ABC transporter AAA_21 PF13304.1 EWC44001.1 - 1.3e-17 64.7 3.8 0.00022 21.2 0.0 4.7 3 2 2 5 5 4 4 AAA domain AAA_17 PF13207.1 EWC44001.1 - 8e-11 42.8 0.2 0.00024 21.9 0.0 3.2 4 0 0 4 4 2 2 AAA domain SMC_N PF02463.14 EWC44001.1 - 8.6e-09 34.9 0.1 0.29 10.3 0.0 4.4 4 0 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_18 PF13238.1 EWC44001.1 - 6.2e-07 29.7 0.8 0.076 13.3 0.0 3.6 4 0 0 4 4 2 2 AAA domain AAA_16 PF13191.1 EWC44001.1 - 1.4e-06 28.4 0.3 0.0061 16.5 0.1 3.0 2 0 0 2 2 2 2 AAA ATPase domain DUF258 PF03193.11 EWC44001.1 - 2.5e-06 26.7 0.4 0.02 14.1 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_29 PF13555.1 EWC44001.1 - 4.8e-06 26.0 0.4 0.067 12.7 0.0 2.9 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.1 EWC44001.1 - 4.9e-06 26.7 0.0 0.12 12.4 0.0 3.0 2 1 0 2 2 2 2 AAA domain Miro PF08477.8 EWC44001.1 - 1.2e-05 25.7 0.1 0.081 13.4 0.0 3.2 3 0 0 3 3 3 2 Miro-like protein MMR_HSR1 PF01926.18 EWC44001.1 - 2e-05 24.5 0.0 0.11 12.4 0.0 3.0 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_23 PF13476.1 EWC44001.1 - 3.3e-05 24.3 14.6 0.019 15.2 0.0 4.6 5 0 0 5 5 5 2 AAA domain AAA_15 PF13175.1 EWC44001.1 - 3.7e-05 22.9 9.8 0.2 10.6 0.1 4.6 4 2 1 5 5 5 2 AAA ATPase domain MobB PF03205.9 EWC44001.1 - 9.1e-05 22.1 0.1 0.66 9.6 0.1 2.8 2 0 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B AAA_28 PF13521.1 EWC44001.1 - 9.4e-05 22.4 0.2 0.39 10.6 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.1 EWC44001.1 - 0.00023 21.0 0.2 1.3 8.8 0.0 3.0 3 0 0 3 3 3 2 AAA domain AAA_10 PF12846.2 EWC44001.1 - 0.00028 20.4 2.6 3.3 7.0 0.1 4.2 4 1 0 4 4 3 1 AAA-like domain AAA PF00004.24 EWC44001.1 - 0.00068 19.8 0.1 1.4 9.1 0.0 3.1 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) SbcCD_C PF13558.1 EWC44001.1 - 0.0009 19.1 0.5 0.28 11.1 0.1 3.5 2 1 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_14 PF13173.1 EWC44001.1 - 0.00093 19.0 0.0 1.3 8.9 0.0 3.1 2 0 0 2 2 2 1 AAA domain NACHT PF05729.7 EWC44001.1 - 0.0014 18.3 0.6 0.57 9.8 0.0 2.6 2 0 0 2 2 2 1 NACHT domain ATP-synt_ab PF00006.20 EWC44001.1 - 0.0031 17.0 0.0 0.2 11.1 0.0 2.4 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain AAA_25 PF13481.1 EWC44001.1 - 0.0041 16.5 0.0 1.7 7.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain ArgK PF03308.11 EWC44001.1 - 0.0051 15.6 3.7 0.46 9.2 0.1 2.8 3 0 0 3 3 3 2 ArgK protein RNA_helicase PF00910.17 EWC44001.1 - 0.0051 16.9 0.0 4.8 7.4 0.0 2.7 2 0 0 2 2 2 0 RNA helicase PduV-EutP PF10662.4 EWC44001.1 - 0.0069 15.8 0.2 2.6 7.5 0.0 2.6 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation cobW PF02492.14 EWC44001.1 - 0.008 15.6 0.4 2.5 7.5 0.2 2.5 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.1 EWC44001.1 - 0.0096 15.5 0.2 1.4 8.5 0.0 3.2 3 0 0 3 3 3 1 AAA domain NTPase_1 PF03266.10 EWC44001.1 - 0.011 15.4 0.2 1.8 8.2 0.1 2.6 2 0 0 2 2 2 0 NTPase AAA_24 PF13479.1 EWC44001.1 - 0.015 14.8 0.1 4.2 6.8 0.1 2.4 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.9 EWC44001.1 - 0.016 14.9 0.5 2.8 7.6 0.0 3.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.7 EWC44001.1 - 0.022 13.8 4.6 0.73 8.8 0.2 3.2 3 0 0 3 3 3 0 Zeta toxin NB-ARC PF00931.17 EWC44001.1 - 0.03 13.1 0.0 3.9 6.2 0.0 2.5 2 0 0 2 2 2 0 NB-ARC domain Dynamin_N PF00350.18 EWC44001.1 - 0.082 12.7 8.9 2 8.1 0.0 4.2 4 1 1 5 5 4 0 Dynamin family Vps26 PF03643.10 EWC44006.1 - 8.2e-126 418.3 0.7 9.4e-126 418.1 0.5 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.24 EWC44006.1 - 0.0028 17.4 0.5 0.98 9.2 0.0 3.1 2 1 2 4 4 4 2 Arrestin (or S-antigen), N-terminal domain SKI PF01202.17 EWC44007.1 - 6.4e-13 48.8 0.0 9e-13 48.3 0.0 1.2 1 0 0 1 1 1 1 Shikimate kinase AAA_33 PF13671.1 EWC44007.1 - 1.5e-10 41.1 0.0 2.2e-10 40.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 EWC44007.1 - 9.7e-10 39.3 0.0 1.3e-09 38.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 EWC44007.1 - 2.8e-08 34.1 0.0 4.8e-08 33.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 EWC44007.1 - 0.00055 20.0 0.0 0.0011 19.0 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA PF00004.24 EWC44007.1 - 0.0038 17.4 0.0 0.009 16.2 0.0 1.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 EWC44007.1 - 0.0045 17.0 0.1 0.0066 16.4 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain RNA_helicase PF00910.17 EWC44007.1 - 0.0082 16.3 0.0 0.014 15.6 0.0 1.4 1 0 0 1 1 1 1 RNA helicase APS_kinase PF01583.15 EWC44007.1 - 0.012 15.3 0.0 0.017 14.7 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase Rad17 PF03215.10 EWC44007.1 - 0.02 13.5 0.0 0.029 13.0 0.0 1.2 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein CoaE PF01121.15 EWC44007.1 - 0.025 14.0 0.0 0.11 11.9 0.0 1.9 2 0 0 2 2 2 0 Dephospho-CoA kinase AAA_14 PF13173.1 EWC44007.1 - 0.026 14.4 0.0 0.043 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain Cytidylate_kin2 PF13189.1 EWC44007.1 - 0.032 14.1 0.1 0.32 10.9 0.0 2.3 1 1 0 1 1 1 0 Cytidylate kinase-like family Zeta_toxin PF06414.7 EWC44007.1 - 0.04 13.0 0.0 0.068 12.2 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_25 PF13481.1 EWC44007.1 - 0.042 13.2 0.1 0.13 11.6 0.0 1.8 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.22 EWC44007.1 - 0.073 13.3 0.0 0.091 13.0 0.0 1.4 1 1 0 1 1 1 0 ABC transporter Mg_chelatase PF01078.16 EWC44007.1 - 0.08 12.1 0.0 0.12 11.5 0.0 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_19 PF13245.1 EWC44007.1 - 0.09 12.5 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 Part of AAA domain PRK PF00485.13 EWC44007.1 - 0.098 12.2 0.0 0.21 11.1 0.0 1.5 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family AAA_5 PF07728.9 EWC44007.1 - 0.14 11.9 0.0 0.34 10.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) NACHT PF05729.7 EWC44007.1 - 0.14 11.7 0.0 0.27 10.8 0.0 1.4 1 0 0 1 1 1 0 NACHT domain DUF2075 PF09848.4 EWC44007.1 - 0.15 11.0 0.0 0.21 10.5 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) 2-oxoacid_dh PF00198.18 EWC44008.1 - 1.6e-74 250.0 0.1 2.4e-74 249.5 0.1 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.17 EWC44008.1 - 8.1e-20 70.2 0.0 1.5e-19 69.3 0.0 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.12 EWC44008.1 - 1.1e-15 56.9 0.5 2.2e-15 55.9 0.4 1.6 1 0 0 1 1 1 1 e3 binding domain Biotin_lipoyl_2 PF13533.1 EWC44008.1 - 0.023 14.3 0.1 0.37 10.4 0.0 2.5 1 1 1 2 2 2 0 Biotin-lipoyl like Sox_C_TAD PF12067.3 EWC44009.1 - 0.63 10.1 13.9 0.051 13.7 2.2 2.2 1 1 1 2 2 2 0 Sox C-terminal transactivation domain bZIP_1 PF00170.16 EWC44010.1 - 4.1e-12 45.8 2.3 7.5e-12 45.0 1.6 1.5 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 EWC44010.1 - 8.9e-07 28.6 6.5 2e-06 27.5 4.5 1.5 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.12 EWC44010.1 - 0.042 14.1 3.7 0.089 13.1 2.6 1.5 1 0 0 1 1 1 0 bZIP Maf transcription factor DivIC PF04977.10 EWC44010.1 - 1 8.8 4.6 1.8 8.0 3.2 1.3 1 0 0 1 1 1 0 Septum formation initiator Rcd1 PF04078.8 EWC44011.1 - 4.2e-132 438.8 1.9 4.2e-132 438.8 1.3 1.5 2 0 0 2 2 2 1 Cell differentiation family, Rcd1-like PAT1 PF09770.4 EWC44011.1 - 0.11 10.7 51.6 0.15 10.2 35.8 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 TFIIA PF03153.8 EWC44011.1 - 0.94 9.3 36.8 1.7 8.4 25.5 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Hid1 PF12722.2 EWC44011.1 - 2.2 5.8 24.3 21 2.6 0.0 2.0 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein Pkinase PF00069.20 EWC44012.1 - 5.4e-75 251.8 0.0 8.2e-75 251.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC44012.1 - 3.7e-38 131.0 0.0 6.5e-38 130.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.14 EWC44012.1 - 1.9e-14 52.8 0.0 3.2e-14 52.0 0.0 1.4 1 0 0 1 1 1 1 Kinase associated domain 1 Kdo PF06293.9 EWC44012.1 - 8.7e-05 21.6 0.0 0.00019 20.5 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 EWC44012.1 - 0.0002 20.4 0.0 0.0005 19.1 0.0 1.7 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 EWC44012.1 - 0.0051 16.5 0.0 0.028 14.1 0.0 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family WaaY PF06176.6 EWC44012.1 - 0.016 14.4 0.2 0.025 13.7 0.2 1.2 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) YrbL-PhoP_reg PF10707.4 EWC44012.1 - 0.026 13.8 0.0 0.047 13.0 0.0 1.4 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL PHD PF00628.24 EWC44013.1 - 1.8e-09 37.1 6.7 1.8e-09 37.1 4.7 1.9 2 0 0 2 2 2 1 PHD-finger PHD_2 PF13831.1 EWC44013.1 - 4e-05 22.8 2.2 4e-05 22.8 1.5 1.8 2 0 0 2 2 2 1 PHD-finger WHIM1 PF15612.1 EWC44013.1 - 0.00031 20.5 0.0 0.0008 19.2 0.0 1.6 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 1 Elf1 PF05129.8 EWC44013.1 - 0.066 12.9 5.1 0.27 10.9 0.4 2.8 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like HMG_box PF00505.14 EWC44014.1 - 1.7e-08 34.5 1.2 3.4e-08 33.6 0.1 2.2 2 0 0 2 2 2 1 HMG (high mobility group) box Sld5 PF05916.6 EWC44015.1 - 1.5e-13 50.9 0.0 3.1e-13 49.9 0.0 1.5 2 0 0 2 2 2 1 GINS complex protein Sulfate_transp PF00916.15 EWC44016.1 - 7.6e-40 136.6 11.3 8e-40 136.6 5.2 2.4 3 0 0 3 3 3 1 Sulfate transporter family cNMP_binding PF00027.24 EWC44016.1 - 2.6e-18 65.6 0.0 5.1e-18 64.6 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain STAS PF01740.16 EWC44016.1 - 6.5e-13 48.1 0.1 1.6e-12 46.8 0.0 1.7 2 0 0 2 2 2 1 STAS domain PH_6 PF15406.1 EWC44017.1 - 2.9e-20 72.4 0.3 2.9e-20 72.4 0.2 3.3 3 0 0 3 3 3 1 Pleckstrin homology domain PH PF00169.24 EWC44017.1 - 0.01 16.0 0.0 0.028 14.6 0.0 1.8 1 0 0 1 1 1 0 PH domain Daxx PF03344.10 EWC44017.1 - 3.3 6.0 31.3 5.2 5.4 21.7 1.2 1 0 0 1 1 1 0 Daxx Family DEAD PF00270.24 EWC44019.1 - 7.6e-45 152.4 0.0 1.7e-44 151.3 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EWC44019.1 - 1e-23 83.0 0.0 2.5e-23 81.7 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.18 EWC44019.1 - 0.0049 15.6 0.0 0.011 14.5 0.0 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.10 EWC44019.1 - 0.02 14.7 0.0 0.089 12.6 0.0 2.1 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit PTS_2-RNA PF01885.11 EWC44020.1 - 2.6e-57 193.1 0.0 3.1e-57 192.8 0.0 1.1 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family TPP_enzyme_N PF02776.13 EWC44022.1 - 3e-35 121.2 0.0 5.4e-35 120.3 0.0 1.3 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.17 EWC44022.1 - 3.9e-19 68.7 0.0 1e-18 67.4 0.0 1.7 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.16 EWC44022.1 - 7.7e-16 58.0 0.0 1.9e-15 56.7 0.0 1.7 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DXP_synthase_N PF13292.1 EWC44022.1 - 0.058 12.3 0.0 0.19 10.6 0.0 1.8 1 0 0 1 1 1 0 1-deoxy-D-xylulose-5-phosphate synthase CIMR PF00878.13 EWC44023.1 - 2.6e-12 46.7 0.0 2.1e-06 27.5 0.0 2.2 2 0 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat Man-6-P_recep PF02157.10 EWC44023.1 - 5.3e-08 32.2 0.0 8.6e-08 31.5 0.0 1.5 1 1 0 1 1 1 1 Mannose-6-phosphate receptor ATG27 PF09451.5 EWC44023.1 - 1.6e-06 27.6 0.4 0.00031 20.0 0.1 2.8 2 1 0 2 2 2 1 Autophagy-related protein 27 DUF4013 PF13197.1 EWC44023.1 - 0.063 12.6 0.3 0.2 10.9 0.4 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4013) ERG4_ERG24 PF01222.12 EWC44024.1 - 1.1e-135 452.4 7.8 1.3e-135 452.3 5.4 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.7 EWC44024.1 - 7.2e-05 22.1 0.5 7.2e-05 22.1 0.4 2.3 3 0 0 3 3 3 1 Protein of unknown function (DUF1295) Scs3p PF10261.4 EWC44025.1 - 2.8e-61 206.6 20.1 5e-61 205.7 13.9 1.4 1 1 0 1 1 1 1 Inositol phospholipid synthesis and fat-storage-inducing TM Methyltransf_23 PF13489.1 EWC44026.1 - 4.5e-10 39.4 0.0 6.4e-10 38.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EWC44026.1 - 3.2e-05 24.3 0.0 9.6e-05 22.8 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EWC44026.1 - 0.00013 22.3 0.0 0.00032 21.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EWC44026.1 - 0.00014 21.5 0.0 0.0011 18.5 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EWC44026.1 - 0.022 15.3 0.0 0.087 13.4 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain CLU PF13236.1 EWC44027.1 - 2.6e-80 268.9 0.0 4e-80 268.3 0.0 1.3 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.2 EWC44027.1 - 1.1e-46 158.9 0.0 3.3e-46 157.3 0.0 1.9 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit 135 CLU_N PF15044.1 EWC44027.1 - 2.2e-26 91.7 0.2 5e-26 90.6 0.1 1.6 1 0 0 1 1 1 1 Mitochondrial function, CLU-N-term TPR_12 PF13424.1 EWC44027.1 - 3.4e-22 78.1 5.3 2.8e-12 46.4 0.1 3.8 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.1 EWC44027.1 - 9.9e-19 66.6 3.1 3.1e-05 23.7 0.0 4.8 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_11 PF13414.1 EWC44027.1 - 4.5e-05 23.0 4.7 0.016 14.8 0.8 3.2 1 1 3 4 4 4 4 TPR repeat TPR_16 PF13432.1 EWC44027.1 - 0.00035 21.1 0.2 0.41 11.3 0.0 3.4 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.12 EWC44027.1 - 0.00059 19.5 0.3 8.5 6.5 0.0 4.2 3 0 0 3 3 3 1 Tetratricopeptide repeat DUF727 PF05303.7 EWC44027.1 - 0.0033 17.2 0.0 0.013 15.2 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF727) TPR_1 PF00515.23 EWC44027.1 - 0.047 13.3 0.5 5.8 6.6 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat Hep_59 PF07052.6 EWC44027.1 - 0.048 14.0 2.4 0.17 12.3 1.7 1.9 1 0 0 1 1 1 0 Hepatocellular carcinoma-associated antigen 59 TPR_8 PF13181.1 EWC44027.1 - 0.11 12.3 0.2 29 4.7 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.1 EWC44027.1 - 0.21 11.8 5.5 1.2e+02 3.3 0.2 4.8 5 0 0 5 5 4 0 Tetratricopeptide repeat Arch_ATPase PF01637.13 EWC44028.1 - 3.5e-07 30.1 0.0 7.4e-07 29.0 0.0 1.5 1 0 0 1 1 1 1 Archaeal ATPase AAA_16 PF13191.1 EWC44028.1 - 4.8e-06 26.6 0.9 0.14 12.1 0.0 3.1 4 0 0 4 4 4 2 AAA ATPase domain AAA_25 PF13481.1 EWC44028.1 - 0.0098 15.3 0.1 0.057 12.8 0.0 2.4 2 1 0 2 2 2 1 AAA domain AAA_29 PF13555.1 EWC44028.1 - 0.013 15.0 0.0 0.027 13.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Fork_head PF00250.13 EWC44029.1 - 7.3e-36 122.0 0.3 1.4e-35 121.2 0.2 1.4 1 0 0 1 1 1 1 Fork head domain FHA PF00498.21 EWC44029.1 - 1.7e-09 37.6 0.0 4e-09 36.4 0.0 1.7 1 0 0 1 1 1 1 FHA domain Fungal_trans PF04082.13 EWC44030.1 - 2.4e-26 92.1 0.0 3.9e-26 91.4 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EWC44030.1 - 3e-09 36.6 14.3 7.4e-09 35.3 9.9 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Gal4_dimer PF03902.8 EWC44030.1 - 0.014 15.3 0.0 0.045 13.6 0.0 1.8 1 0 0 1 1 1 0 Gal4-like dimerisation domain Pkinase PF00069.20 EWC44031.1 - 1.3e-60 204.7 0.0 1.6e-60 204.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC44031.1 - 1.7e-34 119.0 0.0 2.5e-34 118.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EWC44031.1 - 3.7e-07 29.4 0.0 6.5e-07 28.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.6 EWC44031.1 - 0.036 12.9 0.0 0.051 12.4 0.0 1.1 1 0 0 1 1 1 0 Seadornavirus VP7 WD40 PF00400.27 EWC44032.1 - 1.6e-32 110.1 16.3 2.8e-09 36.4 0.2 7.2 6 1 0 6 6 6 5 WD domain, G-beta repeat F-box-like PF12937.2 EWC44032.1 - 1.9e-11 43.4 0.7 3.9e-11 42.4 0.5 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EWC44032.1 - 2.6e-08 33.2 0.0 5.6e-08 32.2 0.0 1.4 1 0 0 1 1 1 1 F-box domain Nup160 PF11715.3 EWC44032.1 - 9.2e-06 24.0 3.9 0.19 9.8 0.0 4.2 2 2 2 4 4 4 4 Nucleoporin Nup120/160 EB1 PF03271.12 EWC44033.1 - 1.2e-17 63.6 0.1 2.1e-17 62.8 0.1 1.4 1 0 0 1 1 1 1 EB1-like C-terminal motif CH PF00307.26 EWC44033.1 - 3.6e-07 30.1 0.4 5.5e-07 29.6 0.3 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain TPR_11 PF13414.1 EWC44034.1 - 5.3e-43 144.5 24.8 7e-18 64.0 2.3 5.7 3 1 4 7 7 7 5 TPR repeat TPR_1 PF00515.23 EWC44034.1 - 8.8e-32 107.4 15.1 4.4e-06 26.0 0.2 8.1 6 1 2 8 8 8 5 Tetratricopeptide repeat TPR_2 PF07719.12 EWC44034.1 - 7.6e-31 103.5 19.0 1.8e-05 24.2 0.1 8.4 6 1 2 8 8 8 6 Tetratricopeptide repeat DnaJ PF00226.26 EWC44034.1 - 3.2e-27 94.0 2.3 8e-27 92.7 1.6 1.7 1 0 0 1 1 1 1 DnaJ domain TPR_16 PF13432.1 EWC44034.1 - 4.1e-22 78.2 22.2 2.4e-07 31.2 0.0 6.5 5 1 1 6 6 5 5 Tetratricopeptide repeat TPR_17 PF13431.1 EWC44034.1 - 3.8e-18 64.1 7.3 0.00028 20.8 0.2 7.0 7 0 0 7 7 6 4 Tetratricopeptide repeat TPR_14 PF13428.1 EWC44034.1 - 3.7e-16 58.1 22.3 0.0014 19.0 0.1 8.4 4 2 4 8 8 7 6 Tetratricopeptide repeat TPR_8 PF13181.1 EWC44034.1 - 2.4e-15 55.0 11.3 0.039 13.7 0.2 8.6 7 1 2 9 9 9 5 Tetratricopeptide repeat TPR_19 PF14559.1 EWC44034.1 - 2.5e-15 56.5 20.1 0.0011 19.3 0.1 6.5 5 2 3 8 8 8 4 Tetratricopeptide repeat TPR_12 PF13424.1 EWC44034.1 - 8.2e-13 48.1 13.7 0.0021 17.9 0.1 6.3 2 2 4 6 6 6 4 Tetratricopeptide repeat Apc3 PF12895.2 EWC44034.1 - 1.9e-12 47.1 3.5 2.1e-05 24.5 0.1 3.5 3 0 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.1 EWC44034.1 - 3.1e-10 39.7 11.5 0.00087 19.0 0.2 5.0 3 2 2 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.1 EWC44034.1 - 3.4e-08 32.6 5.6 0.3 10.9 0.0 7.2 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_10 PF13374.1 EWC44034.1 - 9.1e-05 22.2 14.6 4.3 7.4 0.1 6.6 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_6 PF13174.1 EWC44034.1 - 0.00034 20.8 9.3 12 6.5 0.5 5.9 5 1 0 5 5 4 0 Tetratricopeptide repeat NARP1 PF12569.3 EWC44034.1 - 0.0041 15.9 5.8 0.76 8.4 0.2 3.8 2 2 2 4 4 4 2 NMDA receptor-regulated protein 1 TPR_20 PF14561.1 EWC44034.1 - 0.0066 16.5 16.8 1.3 9.2 0.1 5.2 4 1 0 5 5 5 1 Tetratricopeptide repeat BTAD PF03704.12 EWC44034.1 - 0.0092 16.2 5.5 0.48 10.7 0.2 4.5 3 2 0 3 3 3 1 Bacterial transcriptional activator domain DUF928 PF06051.7 EWC44034.1 - 0.062 12.9 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF928) Fis1_TPR_C PF14853.1 EWC44034.1 - 0.065 13.1 3.9 3.4 7.6 0.0 4.8 5 1 1 6 6 6 0 Fis1 C-terminal tetratricopeptide repeat MIT PF04212.13 EWC44034.1 - 0.27 11.1 0.1 0.27 11.1 0.1 3.7 4 0 0 4 4 3 0 MIT (microtubule interacting and transport) domain TPR_4 PF07721.9 EWC44034.1 - 3.7 8.2 13.1 55 4.6 0.0 5.3 5 0 0 5 5 4 0 Tetratricopeptide repeat DUF4451 PF14616.1 EWC44035.1 - 1.4e-34 118.5 1.1 3.3e-34 117.3 0.8 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4451) PH PF00169.24 EWC44036.1 - 3.8e-12 46.3 1.3 2.1e-10 40.7 0.0 3.2 3 0 0 3 3 3 1 PH domain GRAM PF02893.15 EWC44036.1 - 0.0044 16.5 0.0 0.01 15.3 0.0 1.7 1 0 0 1 1 1 1 GRAM domain PX PF00787.19 EWC44037.1 - 6.9e-16 58.0 0.2 5.1e-15 55.2 0.0 2.1 2 0 0 2 2 2 1 PX domain SNARE PF05739.14 EWC44037.1 - 7e-11 41.6 4.6 1.7e-10 40.4 3.2 1.7 1 0 0 1 1 1 1 SNARE domain ING PF12998.2 EWC44038.1 - 0.00017 21.8 0.1 0.00064 19.9 0.0 2.0 2 0 0 2 2 2 1 Inhibitor of growth proteins N-terminal histone-binding RNase_T PF00929.19 EWC44039.1 - 0.00085 19.6 0.3 0.009 16.3 0.0 2.1 2 0 0 2 2 2 1 Exonuclease RWP-RK PF02042.10 EWC44039.1 - 0.05 13.4 0.9 0.21 11.4 0.3 2.2 2 0 0 2 2 2 0 RWP-RK domain KH_1 PF00013.24 EWC44040.1 - 1.2e-39 133.7 9.1 3.7e-16 58.5 0.2 3.2 3 0 0 3 3 3 3 KH domain KH_3 PF13014.1 EWC44040.1 - 8.5e-29 98.6 13.9 4.9e-11 42.0 2.0 3.4 3 0 0 3 3 3 3 KH domain KH_2 PF07650.12 EWC44040.1 - 2.8e-10 39.6 7.3 0.0038 16.7 0.2 3.3 3 0 0 3 3 3 3 KH domain KH_4 PF13083.1 EWC44040.1 - 3.8e-08 32.8 2.2 0.2 11.3 0.0 3.3 3 0 0 3 3 3 3 KH domain KH_5 PF13184.1 EWC44040.1 - 0.00088 19.0 4.1 0.86 9.4 0.1 3.4 3 0 0 3 3 3 2 NusA-like KH domain dUTPase PF00692.14 EWC44040.1 - 0.0015 18.0 0.2 0.43 10.0 0.0 3.2 3 0 0 3 3 3 1 dUTPase Ku PF02735.11 EWC44041.1 - 2.5e-29 102.1 0.0 5.4e-29 101.0 0.0 1.4 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.10 EWC44041.1 - 6.5e-20 71.5 0.0 1.1e-19 70.7 0.0 1.4 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain Ku_PK_bind PF08785.6 EWC44041.1 - 3.4e-16 59.2 0.3 8.7e-16 57.9 0.1 1.8 2 0 0 2 2 2 1 Ku C terminal domain like VWA_2 PF13519.1 EWC44041.1 - 1.7e-09 38.0 0.1 3.1e-09 37.1 0.1 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain DUF2680 PF10925.3 EWC44041.1 - 0.093 12.6 0.3 0.25 11.2 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2680) NT-C2 PF10358.4 EWC44042.1 - 1.1e-28 99.4 0.0 1.6e-28 99.0 0.0 1.2 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins Abhydrolase_6 PF12697.2 EWC44043.1 - 2.6e-25 89.6 0.0 3.5e-25 89.2 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EWC44043.1 - 7.5e-18 64.9 0.0 3.3e-17 62.8 0.0 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EWC44043.1 - 1.1e-12 47.9 0.0 2.6e-12 46.7 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.11 EWC44043.1 - 3.1e-05 23.5 0.0 0.094 12.1 0.0 2.2 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase BAAT_C PF08840.6 EWC44043.1 - 0.00018 21.2 0.3 0.0032 17.1 0.2 2.1 1 1 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal DLH PF01738.13 EWC44043.1 - 0.0013 18.1 0.1 0.11 11.7 0.1 2.2 2 0 0 2 2 2 1 Dienelactone hydrolase family Thioesterase PF00975.15 EWC44043.1 - 0.0034 17.6 0.0 0.008 16.4 0.0 1.6 2 0 0 2 2 2 1 Thioesterase domain Peptidase_S9 PF00326.16 EWC44043.1 - 0.0053 15.9 0.2 2.5 7.2 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family DUF1100 PF06500.6 EWC44043.1 - 0.0054 15.3 0.0 0.0072 14.9 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1100) PGAP1 PF07819.8 EWC44043.1 - 0.0074 15.8 0.0 0.021 14.4 0.0 1.7 2 0 0 2 2 2 1 PGAP1-like protein UPF0227 PF05728.7 EWC44043.1 - 0.019 14.7 0.0 0.13 12.0 0.0 2.0 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0227) Hydrolase_4 PF12146.3 EWC44043.1 - 0.033 14.0 0.1 0.8 9.5 0.0 2.4 2 0 0 2 2 2 0 Putative lysophospholipase Esterase_phd PF10503.4 EWC44043.1 - 0.049 12.8 0.0 0.092 11.9 0.0 1.5 1 0 0 1 1 1 0 Esterase PHB depolymerase Abhydrolase_3 PF07859.8 EWC44043.1 - 0.092 12.3 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Esterase PF00756.15 EWC44043.1 - 0.13 11.7 0.0 0.21 10.9 0.0 1.4 1 1 0 1 1 1 0 Putative esterase PHD PF00628.24 EWC44044.1 - 3.2e-13 49.1 9.0 6.7e-13 48.1 6.3 1.6 1 0 0 1 1 1 1 PHD-finger ApoM PF11032.3 EWC44044.1 - 0.074 12.6 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 Apolipoprotein M (ApoM) Ribosomal_L24e PF01246.15 EWC44045.1 - 3e-05 23.7 0.2 3e-05 23.7 0.2 1.7 2 0 0 2 2 2 1 Ribosomal protein L24e Peptidase_M41 PF01434.13 EWC44046.1 - 3.1e-75 252.3 0.0 4.4e-75 251.7 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.24 EWC44046.1 - 1.1e-43 148.6 0.0 2.5e-43 147.4 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) FtsH_ext PF06480.10 EWC44046.1 - 3.3e-08 33.6 0.1 8.4e-08 32.3 0.0 1.7 1 0 0 1 1 1 1 FtsH Extracellular AAA_5 PF07728.9 EWC44046.1 - 0.0001 22.0 0.0 0.00034 20.3 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 EWC44046.1 - 0.00076 19.6 0.1 0.074 13.1 0.1 2.7 1 1 0 1 1 1 1 AAA domain TIP49 PF06068.8 EWC44046.1 - 0.0053 15.5 0.0 0.0084 14.8 0.0 1.2 1 0 0 1 1 1 1 TIP49 C-terminus AAA_16 PF13191.1 EWC44046.1 - 0.0077 16.2 0.1 0.079 12.9 0.1 2.4 1 1 1 2 2 2 1 AAA ATPase domain AAA_17 PF13207.1 EWC44046.1 - 0.0084 16.9 0.0 0.025 15.3 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 EWC44046.1 - 0.011 15.5 2.0 0.014 15.1 0.4 1.9 2 0 0 2 2 1 0 Part of AAA domain IstB_IS21 PF01695.12 EWC44046.1 - 0.022 14.1 0.0 0.049 13.0 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein RuvB_N PF05496.7 EWC44046.1 - 0.026 13.5 0.0 0.05 12.6 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus AAA_25 PF13481.1 EWC44046.1 - 0.028 13.8 1.8 0.22 10.8 0.2 2.6 2 1 1 3 3 3 0 AAA domain Zeta_toxin PF06414.7 EWC44046.1 - 0.044 12.8 0.0 0.1 11.6 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin AAA_14 PF13173.1 EWC44046.1 - 0.082 12.8 0.0 0.22 11.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_2 PF07724.9 EWC44046.1 - 0.094 12.6 0.0 0.23 11.3 0.0 1.6 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) API5 PF05918.6 EWC44046.1 - 2.7 6.3 5.7 4.4 5.6 4.0 1.3 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) DUF1295 PF06966.7 EWC44047.1 - 8.1e-34 116.9 9.2 1.1e-33 116.5 6.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) BALF1 PF06861.6 EWC44047.1 - 0.076 12.4 0.1 0.16 11.3 0.1 1.5 1 0 0 1 1 1 0 BALF1 protein MBOAT PF03062.14 EWC44048.1 - 2.9e-36 125.2 27.5 4.9e-36 124.4 17.3 2.3 2 1 0 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.1 EWC44048.1 - 0.0003 20.8 5.0 0.0012 18.8 3.5 2.0 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family Pal1 PF08316.6 EWC44049.1 - 1.2e-46 158.6 0.3 1.2e-46 158.6 0.2 2.3 2 0 0 2 2 2 1 Pal1 cell morphology protein MIP-T3 PF10243.4 EWC44049.1 - 0.00032 19.3 12.2 0.00032 19.3 8.5 1.8 2 0 0 2 2 2 1 Microtubule-binding protein MIP-T3 DUF2146 PF10220.4 EWC44049.1 - 2.2 6.1 5.6 2.9 5.7 3.9 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2146) TMEM171 PF15471.1 EWC44049.1 - 2.4 6.8 5.4 3.9 6.1 3.7 1.3 1 0 0 1 1 1 0 Transmembrane protein family 171 Stm1_N PF09598.5 EWC44050.1 - 4e-14 53.0 1.5 4e-14 53.0 1.0 4.5 4 2 0 4 4 4 1 Stm1 HABP4_PAI-RBP1 PF04774.10 EWC44050.1 - 1e-06 29.1 13.5 1e-06 29.1 9.3 2.7 1 1 1 2 2 2 1 Hyaluronan / mRNA binding family HrpA_pilin PF09589.5 EWC44050.1 - 0.47 10.8 3.7 0.89 9.9 2.6 1.5 1 0 0 1 1 1 0 HrpA pilus formation protein LRR_6 PF13516.1 EWC44051.1 - 2.2e-12 45.6 21.2 2 8.7 0.0 12.0 13 0 0 13 13 13 4 Leucine Rich repeat LRR_4 PF12799.2 EWC44051.1 - 8.1e-12 44.4 26.4 0.022 14.3 0.0 9.6 5 2 7 12 12 12 6 Leucine Rich repeats (2 copies) F-box-like PF12937.2 EWC44051.1 - 1.5e-11 43.7 1.2 4.2e-11 42.3 0.8 1.8 1 0 0 1 1 1 1 F-box-like LRR_8 PF13855.1 EWC44051.1 - 8.1e-09 35.1 34.0 0.00059 19.5 1.3 7.6 4 2 5 9 9 9 6 Leucine rich repeat Recep_L_domain PF01030.19 EWC44051.1 - 7.1e-06 25.9 4.9 0.044 13.7 0.2 4.3 3 1 1 4 4 4 2 Receptor L domain F-box PF00646.28 EWC44051.1 - 0.00062 19.3 0.5 0.0044 16.6 0.0 2.7 3 0 0 3 3 3 1 F-box domain LRR_1 PF00560.28 EWC44051.1 - 0.0007 19.2 35.6 3.8 7.9 0.4 11.0 8 4 1 9 9 9 2 Leucine Rich Repeat LRR_2 PF07723.8 EWC44051.1 - 3.6 8.2 7.0 2 9.0 0.2 4.1 4 0 0 4 4 4 0 Leucine Rich Repeat Adaptin_N PF01602.15 EWC44052.1 - 9.3e-141 469.7 3.5 1.1e-140 469.4 2.4 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.15 EWC44052.1 - 1.6e-20 73.5 0.2 3.5e-20 72.4 0.1 1.6 1 0 0 1 1 1 1 Adaptin C-terminal domain HEAT_2 PF13646.1 EWC44052.1 - 1.7e-07 31.4 1.7 0.017 15.4 0.0 4.5 4 2 0 4 4 4 2 HEAT repeats HEAT PF02985.17 EWC44052.1 - 0.011 15.8 4.2 26 5.2 0.0 5.3 5 1 0 5 5 5 0 HEAT repeat Cnd1 PF12717.2 EWC44052.1 - 0.026 14.4 6.8 0.071 12.9 0.8 3.5 3 1 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 Arm PF00514.18 EWC44052.1 - 0.034 13.9 0.0 61 3.6 0.0 4.7 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.1 EWC44052.1 - 0.038 14.4 1.6 7.7 7.1 0.1 4.8 3 2 1 4 4 4 0 HEAT-like repeat TIP120 PF08623.5 EWC44052.1 - 0.053 13.1 1.8 0.13 11.8 0.1 2.4 2 0 0 2 2 2 0 TATA-binding protein interacting (TIP20) Topoisom_bac PF01131.15 EWC44053.1 - 1.6e-88 297.2 0.0 4.1e-83 279.4 0.0 2.2 2 0 0 2 2 2 2 DNA topoisomerase Toprim PF01751.17 EWC44053.1 - 1.1e-16 60.6 0.0 2.1e-16 59.7 0.0 1.5 1 0 0 1 1 1 1 Toprim domain DUF3535 PF12054.3 EWC44054.1 - 2e-143 478.2 0.3 5e-141 470.3 0.0 3.1 3 0 0 3 3 3 2 Domain of unknown function (DUF3535) SNF2_N PF00176.18 EWC44054.1 - 1.6e-77 260.3 0.0 2.3e-77 259.7 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain HEAT PF02985.17 EWC44054.1 - 4.5e-19 66.7 8.7 0.025 14.6 0.0 9.0 8 0 0 8 8 8 6 HEAT repeat Helicase_C PF00271.26 EWC44054.1 - 7.4e-12 44.9 0.0 2.1e-11 43.4 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HEAT_2 PF13646.1 EWC44054.1 - 1.5e-08 34.7 10.2 0.0094 16.2 0.0 7.5 4 2 2 6 6 6 2 HEAT repeats DEAD PF00270.24 EWC44054.1 - 1.5e-05 24.6 0.0 4.7e-05 22.9 0.0 1.9 1 0 0 1 1 1 1 DEAD/DEAH box helicase HEAT_EZ PF13513.1 EWC44054.1 - 0.00013 22.3 14.4 13 6.4 0.0 9.1 9 1 1 10 10 9 1 HEAT-like repeat CLASP_N PF12348.3 EWC44054.1 - 0.00052 19.4 0.5 0.021 14.1 0.0 3.7 4 1 1 5 5 5 1 CLASP N terminal Vac14_Fab1_bd PF12755.2 EWC44054.1 - 0.0058 16.9 0.0 3.2 8.2 0.0 3.9 3 1 1 4 4 4 1 Vacuolar 14 Fab1-binding region Ipi1_N PF12333.3 EWC44054.1 - 0.0094 15.8 4.4 21 5.1 0.0 5.4 6 0 0 6 6 6 0 Rix1 complex component involved in 60S ribosome maturation Cnd1 PF12717.2 EWC44054.1 - 0.067 13.0 2.5 8.6 6.1 0.0 4.6 5 1 1 6 6 6 0 non-SMC mitotic condensation complex subunit 1 Pkinase PF00069.20 EWC44055.1 - 5.4e-38 130.6 0.0 8.1e-38 130.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC44055.1 - 2.3e-28 98.9 0.0 3.5e-28 98.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 EWC44055.1 - 0.012 15.4 0.0 4.3 6.9 0.0 2.7 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.9 EWC44055.1 - 0.25 10.3 0.0 0.43 9.6 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 EWC44055.1 - 0.38 9.6 0.0 0.58 9.0 0.0 1.2 1 0 0 1 1 1 0 Kinase-like bZIP_1 PF00170.16 EWC44057.1 - 9.7e-06 25.4 6.4 9.7e-06 25.4 4.5 1.7 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.10 EWC44057.1 - 0.0053 16.5 7.7 0.012 15.3 5.4 1.6 1 0 0 1 1 1 1 Basic region leucine zipper Glutaredoxin2_C PF04399.8 EWC44057.1 - 0.076 12.5 0.8 0.14 11.7 0.5 1.3 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain DUF4407 PF14362.1 EWC44057.1 - 0.26 10.1 3.8 0.23 10.4 1.5 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) bZIP_Maf PF03131.12 EWC44057.1 - 0.76 10.1 8.1 0.31 11.3 3.7 1.8 2 0 0 2 2 2 0 bZIP Maf transcription factor Arrestin_C PF02752.17 EWC44058.1 - 6.3e-09 36.0 0.0 1.2e-08 35.1 0.0 1.5 1 0 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.24 EWC44058.1 - 0.014 15.2 0.0 0.044 13.6 0.0 1.9 2 0 0 2 2 2 0 Arrestin (or S-antigen), N-terminal domain Med10 PF09748.4 EWC44059.1 - 1.4e-31 108.9 0.1 1.7e-31 108.7 0.0 1.1 1 0 0 1 1 1 1 Transcription factor subunit Med10 of Mediator complex Nuc_sug_transp PF04142.10 EWC44060.1 - 5.1e-07 29.0 0.6 8.1e-07 28.3 0.4 1.3 1 0 0 1 1 1 1 Nucleotide-sugar transporter UAA PF08449.6 EWC44060.1 - 2.1e-06 26.8 8.4 4.2e-06 25.9 5.9 1.4 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.15 EWC44060.1 - 0.00057 19.9 24.6 0.018 15.0 3.0 3.0 3 1 0 3 3 3 2 EamA-like transporter family TPT PF03151.11 EWC44060.1 - 0.0093 15.6 17.0 0.054 13.1 5.1 2.4 2 0 0 2 2 2 2 Triose-phosphate Transporter family LPAM_1 PF08139.7 EWC44060.1 - 7.9 6.8 7.4 0.47 10.7 0.2 2.9 3 0 0 3 3 3 0 Prokaryotic membrane lipoprotein lipid attachment site F-box-like PF12937.2 EWC44061.1 - 1.9e-09 37.0 0.1 4.7e-09 35.8 0.0 1.7 1 0 0 1 1 1 1 F-box-like LRR_6 PF13516.1 EWC44061.1 - 6.7e-08 31.8 13.5 3.6 7.9 0.1 9.0 10 0 0 10 10 10 3 Leucine Rich repeat F-box PF00646.28 EWC44061.1 - 2.7e-06 26.8 0.1 9e-06 25.2 0.1 1.9 1 0 0 1 1 1 1 F-box domain LRR_1 PF00560.28 EWC44061.1 - 3.8e-05 23.1 16.2 4.6 7.6 0.3 7.9 8 1 0 8 8 8 1 Leucine Rich Repeat LRR_4 PF12799.2 EWC44061.1 - 0.0019 17.7 12.1 0.47 10.1 0.0 6.3 4 2 1 5 5 5 1 Leucine Rich repeats (2 copies) PXA PF02194.10 EWC44062.1 - 1.1e-44 152.2 1.9 1.4e-44 151.9 0.7 1.6 2 0 0 2 2 2 1 PXA domain Nexin_C PF08628.7 EWC44062.1 - 4.8e-07 29.8 0.0 1.4e-06 28.3 0.0 1.9 2 0 0 2 2 2 1 Sorting nexin C terminal HTH_Tnp_Tc5 PF03221.11 EWC44063.1 - 5.9e-08 32.4 0.0 1.3e-07 31.3 0.0 1.6 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.8 EWC44063.1 - 0.0019 17.6 0.0 0.0044 16.4 0.0 1.6 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain MarR PF01047.17 EWC44063.1 - 0.0062 16.2 0.0 0.021 14.5 0.0 1.9 2 0 0 2 2 2 1 MarR family HTH_23 PF13384.1 EWC44063.1 - 0.01 15.4 0.0 0.021 14.4 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_Crp_2 PF13545.1 EWC44063.1 - 0.02 14.6 0.0 0.062 13.0 0.0 1.8 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain Sigma70_r4 PF04545.11 EWC44063.1 - 0.022 14.0 0.2 0.049 12.9 0.1 1.6 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_38 PF13936.1 EWC44063.1 - 0.03 13.8 0.2 0.056 13.0 0.1 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_Tnp_4 PF13613.1 EWC44063.1 - 0.032 13.7 0.0 0.23 11.0 0.0 2.2 3 0 0 3 3 3 0 Helix-turn-helix of DDE superfamily endonuclease MarR_2 PF12802.2 EWC44063.1 - 0.052 13.2 0.1 0.17 11.5 0.0 1.9 2 0 0 2 2 2 0 MarR family CDO_I PF05995.7 EWC44064.1 - 3.9e-39 133.6 0.1 5.2e-39 133.1 0.1 1.1 1 0 0 1 1 1 1 Cysteine dioxygenase type I DUF1637 PF07847.7 EWC44064.1 - 0.052 12.9 1.1 0.28 10.4 0.8 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1637) WD40 PF00400.27 EWC44065.1 - 0.015 15.1 0.7 1.5 8.8 0.0 3.4 3 0 0 3 3 3 0 WD domain, G-beta repeat zf-RING_2 PF13639.1 EWC44065.1 - 4.7 7.1 10.0 2.4 8.0 2.8 3.0 2 1 0 2 2 2 0 Ring finger domain DUF2361 PF10153.4 EWC44066.1 - 4.4e-27 94.5 6.4 5.1e-20 71.7 0.6 2.7 3 0 0 3 3 3 2 Uncharacterised conserved protein (DUF2361) Strep_SA_rep PF06696.6 EWC44066.1 - 0.032 14.0 0.1 0.079 12.7 0.0 1.7 1 0 0 1 1 1 0 Streptococcal surface antigen repeat Asp-B-Hydro_N PF05279.6 EWC44066.1 - 0.038 13.8 0.7 0.086 12.6 0.5 1.5 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Fungal_trans PF04082.13 EWC44067.1 - 1.7e-32 112.3 0.0 4.8e-32 110.8 0.0 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EWC44067.1 - 3.2e-11 42.9 12.6 5.6e-11 42.1 8.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain HlyC PF02794.11 EWC44069.1 - 0.11 12.0 0.0 0.25 10.9 0.0 1.5 2 0 0 2 2 2 0 RTX toxin acyltransferase family Prenyltransf PF01255.14 EWC44070.1 - 2.7e-28 98.6 0.1 3.1e-28 98.4 0.1 1.0 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase Peptidase_M29 PF02073.10 EWC44070.1 - 0.1 11.3 0.0 0.11 11.2 0.0 1.0 1 0 0 1 1 1 0 Thermophilic metalloprotease (M29) MAD PF05557.8 EWC44071.1 - 4.1e-19 68.2 67.8 1.7e-17 62.8 47.1 2.7 1 1 0 1 1 1 1 Mitotic checkpoint protein Prominin PF05478.6 EWC44071.1 - 3.9 4.8 9.8 11 3.4 6.8 1.7 1 0 0 1 1 1 0 Prominin BLOC1_2 PF10046.4 EWC44071.1 - 8.1 6.6 28.2 0.064 13.4 2.1 5.2 4 1 1 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 zf-C2H2 PF00096.21 EWC44072.1 - 4.1e-20 70.8 28.7 1.6e-05 24.9 1.2 4.5 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 EWC44072.1 - 4.4e-19 67.7 22.7 1.9e-07 31.0 0.6 4.8 4 0 0 4 4 4 4 Zinc-finger double domain zf-C2H2_4 PF13894.1 EWC44072.1 - 4.2e-09 36.0 26.3 0.0061 16.8 1.2 4.7 4 0 0 4 4 4 4 C2H2-type zinc finger zf-TRAF PF02176.13 EWC44072.1 - 0.0038 17.5 2.0 0.0038 17.5 1.4 3.1 2 1 1 3 3 3 2 TRAF-type zinc finger zf-met PF12874.2 EWC44072.1 - 0.39 10.9 11.0 0.99 9.7 0.1 4.2 4 0 0 4 4 4 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 EWC44072.1 - 1 9.5 8.9 6.5 7.0 0.2 3.3 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding RPAP2_Rtr1 PF04181.8 EWC44072.1 - 9.1 6.4 8.3 7.8e+02 0.2 5.8 3.0 1 1 0 1 1 1 0 Rtr1/RPAP2 family DUF1162 PF06650.7 EWC44073.1 - 9.4e-87 290.7 0.1 3.6e-84 282.2 0.1 3.2 3 0 0 3 3 3 2 Protein of unknown function (DUF1162) Chorein_N PF12624.2 EWC44073.1 - 1.2e-44 150.6 0.2 4e-44 148.9 0.1 2.1 1 0 0 1 1 1 1 N-terminal region of Chorein, a TM vesicle-mediated sorter ATG_C PF09333.6 EWC44073.1 - 6e-06 26.3 0.0 3.4e-05 23.9 0.0 2.3 2 0 0 2 2 2 1 ATG C terminal domain Utp14 PF04615.8 EWC44074.1 - 1.7e-72 244.7 18.2 9e-37 126.6 0.0 3.1 2 1 1 3 3 3 3 Utp14 protein DUF4549 PF15082.1 EWC44074.1 - 0.082 12.5 0.2 0.14 11.7 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4549) CLASP_N PF12348.3 EWC44075.1 - 9.7e-09 34.9 0.2 1.4e-07 31.1 0.2 2.3 2 0 0 2 2 2 1 CLASP N terminal HEAT PF02985.17 EWC44075.1 - 1.1e-07 31.2 1.8 2.3 8.5 0.0 6.4 6 0 0 6 6 6 2 HEAT repeat HEAT_2 PF13646.1 EWC44075.1 - 1.7e-07 31.3 0.1 0.011 16.0 0.0 4.4 3 2 0 4 4 4 1 HEAT repeats MMS19_N PF14500.1 EWC44075.1 - 1.4e-05 24.5 0.2 4.1e-05 22.9 0.1 1.9 1 1 0 1 1 1 1 Dos2-interacting transcription regulator of RNA-Pol-II Adaptin_N PF01602.15 EWC44075.1 - 0.0015 16.9 0.4 0.045 12.0 0.2 2.4 2 1 0 2 2 2 1 Adaptin N terminal region Proteasom_PSMB PF10508.4 EWC44075.1 - 0.013 13.7 3.5 0.028 12.7 0.1 2.5 3 0 0 3 3 3 0 Proteasome non-ATPase 26S subunit MOR2-PAG1_C PF14225.1 EWC44075.1 - 0.11 12.1 0.2 0.56 9.9 0.0 2.2 3 0 0 3 3 3 0 Cell morphogenesis C-terminal Transket_pyr PF02779.19 EWC44076.1 - 2.8e-63 212.6 0.0 4.3e-63 212.0 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.15 EWC44076.1 - 1.7e-56 191.1 0.0 2.5e-56 190.5 0.0 1.3 1 0 0 1 1 1 1 Dehydrogenase E1 component Colicin_C PF12106.3 EWC44076.1 - 0.012 15.1 0.0 0.03 13.9 0.0 1.6 1 0 0 1 1 1 0 Colicin C terminal ribonuclease domain ING PF12998.2 EWC44077.1 - 3.1e-12 46.6 0.0 6.6e-12 45.6 0.0 1.6 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.24 EWC44077.1 - 1.9e-09 37.0 7.8 3e-09 36.4 5.4 1.3 1 0 0 1 1 1 1 PHD-finger WD40 PF00400.27 EWC44078.1 - 9e-57 187.0 17.4 1.4e-09 37.4 0.0 7.9 7 0 0 7 7 7 7 WD domain, G-beta repeat F-box-like PF12937.2 EWC44078.1 - 7.7e-10 38.3 0.4 1.6e-09 37.3 0.3 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EWC44078.1 - 3e-09 36.3 0.2 6.7e-09 35.1 0.2 1.6 1 0 0 1 1 1 1 F-box domain PQQ_2 PF13360.1 EWC44078.1 - 0.00012 21.6 1.3 0.079 12.4 0.4 3.2 1 1 1 2 2 2 1 PQQ-like domain adh_short PF00106.20 EWC44080.1 - 0.00012 22.0 0.2 0.00098 19.0 0.1 2.3 2 1 0 2 2 2 1 short chain dehydrogenase KR PF08659.5 EWC44080.1 - 0.1 12.2 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 KR domain ATP_bind_3 PF01171.15 EWC44081.1 - 1.9e-18 66.6 0.0 2.9e-18 66.0 0.0 1.3 1 0 0 1 1 1 1 PP-loop family DUF2392 PF10288.4 EWC44081.1 - 0.045 14.0 0.0 0.078 13.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2392) tRNA_Me_trans PF03054.11 EWC44081.1 - 0.053 12.0 0.0 0.087 11.3 0.0 1.4 1 0 0 1 1 1 0 tRNA methyl transferase TF_Zn_Ribbon PF08271.7 EWC44081.1 - 0.061 12.6 1.5 0.28 10.5 0.1 2.3 2 0 0 2 2 2 0 TFIIB zinc-binding Asn_synthase PF00733.16 EWC44081.1 - 0.1 12.0 0.1 0.21 11.0 0.0 1.5 1 1 0 1 1 1 0 Asparagine synthase DUF791 PF05631.9 EWC44081.1 - 0.15 10.6 0.0 0.26 9.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF791) Cyclin_N PF00134.18 EWC44082.1 - 1e-12 47.7 0.0 1.7e-12 47.0 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.6 EWC44082.1 - 1.5e-11 44.8 0.0 3.2e-11 43.8 0.0 1.6 1 0 0 1 1 1 1 Cyclin Aha1_N PF09229.6 EWC44083.1 - 2e-20 73.0 0.1 3.6e-12 46.2 0.0 2.2 1 1 1 2 2 2 2 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.6 EWC44083.1 - 5.4e-13 49.1 0.1 8.5e-13 48.4 0.0 1.3 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein MIP-T3 PF10243.4 EWC44083.1 - 0.067 11.6 0.5 0.075 11.4 0.3 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Uds1 PF15456.1 EWC44084.1 - 1e-33 115.9 1.1 1e-33 115.9 0.8 8.3 4 1 4 8 8 8 1 Up-regulated During Septation DUF1192 PF06698.6 EWC44084.1 - 0.0049 16.6 1.2 0.0049 16.6 0.8 6.9 7 0 0 7 7 7 1 Protein of unknown function (DUF1192) GAS PF13851.1 EWC44084.1 - 0.0068 15.6 10.4 0.0068 15.6 7.2 6.1 4 1 1 6 6 6 3 Growth-arrest specific micro-tubule binding DUF2580 PF10824.3 EWC44084.1 - 0.058 13.7 0.3 0.058 13.7 0.2 4.5 5 0 0 5 5 5 0 Protein of unknown function (DUF2580) DUF3437 PF11919.3 EWC44085.1 - 3e-32 110.1 0.0 2.7e-31 107.1 0.0 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3437) HEAT PF02985.17 EWC44085.1 - 0.0013 18.6 0.1 2.9 8.1 0.0 4.2 3 0 0 3 3 3 2 HEAT repeat PaaX PF07848.7 EWC44086.1 - 0.1 12.6 0.0 0.25 11.3 0.0 1.6 1 0 0 1 1 1 0 PaaX-like protein DUF2207 PF09972.4 EWC44086.1 - 0.33 9.4 2.0 0.35 9.3 1.4 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF2628 PF10947.3 EWC44086.1 - 6.3 6.6 6.8 3.5 7.4 3.1 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2628) BSD PF03909.12 EWC44088.1 - 3.9e-24 84.1 0.8 1.3e-11 44.0 0.1 2.6 2 0 0 2 2 2 2 BSD domain TFIIH_BTF_p62_N PF08567.6 EWC44088.1 - 4.4e-17 61.4 0.3 9.8e-17 60.3 0.2 1.6 1 0 0 1 1 1 1 TFIIH p62 subunit, N-terminal domain PTB PF08416.8 EWC44088.1 - 0.0091 15.9 1.3 0.017 15.0 0.1 2.0 3 0 0 3 3 3 1 Phosphotyrosine-binding domain VID27 PF08553.5 EWC44089.1 - 1.2e-295 982.8 0.0 1.4e-295 982.6 0.0 1.0 1 0 0 1 1 1 1 VID27 cytoplasmic protein MGC-24 PF05283.6 EWC44089.1 - 4.2 7.1 6.5 7.5 6.3 4.5 1.3 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24) Usp PF00582.21 EWC44090.1 - 6.8e-10 39.2 0.1 0.0018 18.4 0.0 2.7 2 0 0 2 2 2 2 Universal stress protein family Peptidase_M6 PF05547.6 EWC44091.1 - 2e-07 29.4 0.2 0.011 13.7 0.5 2.2 2 0 0 2 2 2 2 Immune inhibitor A peptidase M6 MFS_1 PF07690.11 EWC44093.1 - 1.5e-45 155.4 44.3 1.5e-45 155.4 30.7 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.8 EWC44093.1 - 2.7e-17 62.2 27.5 3.9e-17 61.6 19.1 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.19 EWC44093.1 - 1.3e-13 50.3 13.0 1.3e-13 50.3 9.0 3.1 2 1 1 3 3 3 1 Sugar (and other) transporter Thioesterase PF00975.15 EWC44094.1 - 3.5e-18 66.6 0.0 7e-18 65.6 0.0 1.5 1 1 0 1 1 1 1 Thioesterase domain Abhydrolase_6 PF12697.2 EWC44094.1 - 1.1e-07 31.9 0.0 1.4e-07 31.6 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.11 EWC44094.1 - 0.017 14.5 0.0 0.025 14.0 0.0 1.2 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Abhydrolase_1 PF00561.15 EWC44094.1 - 0.042 13.3 0.1 0.24 10.9 0.0 1.9 2 0 0 2 2 2 0 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EWC44094.1 - 0.043 13.5 0.0 0.053 13.2 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family AMP-binding PF00501.23 EWC44095.1 - 6.6e-84 281.7 0.0 9.7e-84 281.1 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme ketoacyl-synt PF00109.21 EWC44095.1 - 1e-72 244.7 0.0 1.8e-72 243.8 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.16 EWC44095.1 - 1.4e-58 198.7 0.0 2.6e-58 197.8 0.0 1.4 1 0 0 1 1 1 1 Acyl transferase domain KR PF08659.5 EWC44095.1 - 1e-53 181.7 0.0 3.3e-53 180.0 0.0 2.0 1 0 0 1 1 1 1 KR domain Condensation PF00668.15 EWC44095.1 - 2e-47 161.5 0.9 3.1e-47 160.8 0.0 1.8 2 0 0 2 2 2 1 Condensation domain adh_short PF00106.20 EWC44095.1 - 1e-41 142.6 0.0 3.9e-41 140.7 0.0 2.1 2 0 0 2 2 2 1 short chain dehydrogenase Ketoacyl-synt_C PF02801.17 EWC44095.1 - 3e-38 130.3 0.1 7.6e-38 129.0 0.1 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain NAD_binding_4 PF07993.7 EWC44095.1 - 1.5e-32 112.4 0.0 1.5e-31 109.2 0.0 2.2 2 0 0 2 2 2 1 Male sterility protein PP-binding PF00550.20 EWC44095.1 - 2.6e-20 72.4 0.1 4.5e-11 42.8 0.0 2.9 2 0 0 2 2 2 2 Phosphopantetheine attachment site PS-DH PF14765.1 EWC44095.1 - 5.3e-17 61.9 0.0 9.9e-17 61.0 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase HxxPF_rpt PF13745.1 EWC44095.1 - 2e-16 60.0 0.6 4.3e-16 58.9 0.1 1.9 2 0 0 2 2 1 1 HxxPF-repeated domain ACP_syn_III PF08545.5 EWC44095.1 - 0.021 14.4 0.1 0.065 12.8 0.1 1.9 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Thiolase_N PF00108.18 EWC44095.1 - 0.037 13.0 0.2 0.073 12.0 0.1 1.4 1 0 0 1 1 1 0 Thiolase, N-terminal domain Ribosomal_L30_N PF08079.7 EWC44097.1 - 4.5e-23 81.0 15.2 7.7e-23 80.3 10.5 1.4 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Ribosomal_L30 PF00327.15 EWC44097.1 - 2.5e-19 68.6 1.1 6.1e-19 67.3 0.8 1.7 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Aminotran_5 PF00266.14 EWC44097.1 - 4.6e-12 45.3 0.0 6e-12 44.9 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.12 EWC44097.1 - 0.0066 15.5 0.1 0.015 14.3 0.0 1.5 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family DNA_pol_B PF00136.16 EWC44098.1 - 1.3e-107 360.4 0.0 3.1e-107 359.2 0.0 1.6 1 1 0 1 1 1 1 DNA polymerase family B zf-DNA_Pol PF08996.5 EWC44098.1 - 1.5e-51 174.4 2.8 2.8e-51 173.5 2.0 1.5 1 0 0 1 1 1 1 DNA Polymerase alpha zinc finger DNA_pol_B_exo1 PF03104.14 EWC44098.1 - 1.9e-36 125.5 0.0 4.4e-36 124.3 0.0 1.6 2 0 0 2 2 2 1 DNA polymerase family B, exonuclease domain DNA_pol_alpha_N PF12254.3 EWC44098.1 - 2.6e-21 75.1 7.4 2.6e-21 75.1 5.2 2.8 3 0 0 3 3 3 1 DNA polymerase alpha subunit p180 N terminal Fungal_trans PF04082.13 EWC44099.1 - 3.4e-30 104.7 0.0 6.2e-30 103.9 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EWC44099.1 - 0.15 11.9 3.0 0.27 11.1 2.1 1.3 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain PWI PF01480.12 EWC44101.1 - 1.3e-08 34.7 0.8 3.7e-08 33.3 0.5 1.8 1 0 0 1 1 1 1 PWI domain RRM_1 PF00076.17 EWC44101.1 - 2.8e-05 23.6 0.0 6e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AAA PF00004.24 EWC44102.1 - 2.6e-37 127.9 0.0 7.6e-37 126.4 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 EWC44102.1 - 1.4e-07 31.7 0.1 4.4e-05 23.6 0.1 2.8 2 1 0 2 2 1 1 AAA domain RuvB_N PF05496.7 EWC44102.1 - 6.8e-07 28.5 0.0 1.5e-06 27.4 0.0 1.6 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_14 PF13173.1 EWC44102.1 - 9.6e-07 28.7 0.0 1.9e-06 27.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 EWC44102.1 - 1.2e-06 28.6 0.2 0.001 19.0 0.0 2.7 1 1 2 3 3 3 1 AAA ATPase domain AAA_17 PF13207.1 EWC44102.1 - 2.1e-06 28.5 0.1 2.8e-05 24.9 0.0 2.4 2 1 0 2 2 2 1 AAA domain AAA_5 PF07728.9 EWC44102.1 - 5.4e-06 26.1 0.2 8.8e-05 22.2 0.1 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.9 EWC44102.1 - 4e-05 23.6 0.0 0.00011 22.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) Zeta_toxin PF06414.7 EWC44102.1 - 0.00016 20.8 0.0 0.00024 20.2 0.0 1.5 1 1 0 1 1 1 1 Zeta toxin IstB_IS21 PF01695.12 EWC44102.1 - 0.00018 20.9 0.0 0.00037 19.9 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_33 PF13671.1 EWC44102.1 - 0.00025 20.9 0.0 0.0005 19.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.16 EWC44102.1 - 0.0005 19.2 0.2 0.0015 17.7 0.1 1.7 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_25 PF13481.1 EWC44102.1 - 0.00062 19.2 1.2 0.037 13.4 0.1 2.7 2 1 0 2 2 2 1 AAA domain Sigma54_activ_2 PF14532.1 EWC44102.1 - 0.0018 18.3 0.0 0.0052 16.8 0.0 1.7 2 0 0 2 2 1 1 Sigma-54 interaction domain AAA_28 PF13521.1 EWC44102.1 - 0.0025 17.8 0.0 0.0066 16.4 0.0 1.7 2 0 0 2 2 1 1 AAA domain TIP49 PF06068.8 EWC44102.1 - 0.0029 16.3 0.1 0.067 11.8 0.0 2.2 2 0 0 2 2 2 1 TIP49 C-terminus RNA_helicase PF00910.17 EWC44102.1 - 0.0029 17.7 0.0 0.0057 16.8 0.0 1.7 1 1 0 1 1 1 1 RNA helicase NACHT PF05729.7 EWC44102.1 - 0.0041 16.7 0.1 0.0097 15.5 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_18 PF13238.1 EWC44102.1 - 0.0048 17.2 0.2 0.011 16.0 0.0 1.8 2 1 0 2 2 1 1 AAA domain AAA_24 PF13479.1 EWC44102.1 - 0.0051 16.4 0.1 0.01 15.4 0.1 1.5 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 EWC44102.1 - 0.0083 15.8 0.1 0.039 13.6 0.0 2.2 3 0 0 3 3 1 1 Part of AAA domain Guanylate_kin PF00625.16 EWC44102.1 - 0.012 15.0 0.0 0.43 10.0 0.0 2.6 3 0 0 3 3 3 0 Guanylate kinase Parvo_NS1 PF01057.12 EWC44102.1 - 0.012 14.4 0.0 0.018 13.9 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 ABC_tran PF00005.22 EWC44102.1 - 0.026 14.8 0.0 0.055 13.7 0.0 1.6 1 0 0 1 1 1 0 ABC transporter AAA_10 PF12846.2 EWC44102.1 - 0.029 13.8 0.2 1.6 8.0 0.0 2.9 3 0 0 3 3 3 0 AAA-like domain Rad17 PF03215.10 EWC44102.1 - 0.033 12.8 0.0 0.048 12.3 0.0 1.3 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein Sigma54_activat PF00158.21 EWC44102.1 - 0.041 13.3 0.0 0.11 11.9 0.0 1.7 2 0 0 2 2 1 0 Sigma-54 interaction domain Arch_ATPase PF01637.13 EWC44102.1 - 0.047 13.3 0.2 0.24 11.0 0.0 2.1 2 1 1 3 3 2 0 Archaeal ATPase AAA_21 PF13304.1 EWC44102.1 - 0.051 13.5 0.4 7.7 6.3 0.2 2.4 1 1 1 2 2 2 0 AAA domain CPT PF07931.7 EWC44102.1 - 0.051 13.1 0.0 0.09 12.3 0.0 1.4 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein DUF815 PF05673.8 EWC44102.1 - 0.054 12.4 0.0 0.093 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) SKI PF01202.17 EWC44102.1 - 0.061 13.1 0.0 0.22 11.3 0.0 1.9 2 0 0 2 2 2 0 Shikimate kinase KaiC PF06745.8 EWC44102.1 - 0.066 12.3 0.1 1.4 7.9 0.0 2.3 1 1 1 2 2 2 0 KaiC Oxidored_nitro PF00148.14 EWC44102.1 - 0.068 11.8 0.0 0.97 8.0 0.0 2.2 2 1 0 2 2 2 0 Nitrogenase component 1 type Oxidoreductase NB-ARC PF00931.17 EWC44102.1 - 0.08 11.7 0.0 0.14 10.9 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain UPF0079 PF02367.12 EWC44102.1 - 0.16 11.6 0.0 0.29 10.7 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 PGI PF00342.14 EWC44103.1 - 2.4e-216 718.8 0.3 2.7e-216 718.6 0.2 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase Spc97_Spc98 PF04130.8 EWC44104.1 - 3.7e-133 444.7 0.8 4.6e-133 444.3 0.5 1.1 1 0 0 1 1 1 1 Spc97 / Spc98 family cwf21 PF08312.7 EWC44104.1 - 4.2 7.2 6.1 9.1 6.2 0.8 2.9 3 0 0 3 3 3 0 cwf21 domain SMC_N PF02463.14 EWC44105.1 - 2e-69 233.1 0.0 3.3e-69 232.4 0.0 1.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.8 EWC44105.1 - 1.6e-23 82.9 0.2 1.8e-22 79.5 0.0 2.7 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.1 EWC44105.1 - 2.9e-12 47.3 10.0 2.9e-12 47.3 7.0 6.7 2 2 1 3 3 3 1 AAA domain AAA_21 PF13304.1 EWC44105.1 - 4.7e-11 43.1 10.4 1.8e-05 24.8 0.6 3.4 3 1 0 3 3 3 2 AAA domain APG6 PF04111.7 EWC44105.1 - 0.00061 18.9 4.5 0.00061 18.9 3.1 6.3 3 2 3 6 6 6 2 Autophagy protein Apg6 AAA_29 PF13555.1 EWC44105.1 - 0.00083 18.8 0.0 0.002 17.6 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain Reo_sigmaC PF04582.7 EWC44105.1 - 0.68 9.0 29.8 0.19 10.8 1.2 5.4 3 2 1 6 6 6 0 Reovirus sigma C capsid protein ABC_tran PF00005.22 EWC44105.1 - 1.1 9.5 24.1 1.4 9.2 0.0 5.7 3 2 0 3 3 3 0 ABC transporter GDI PF00996.13 EWC44106.1 - 9.2e-152 505.3 0.0 1.2e-151 505.0 0.0 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor MRP-L47 PF06984.8 EWC44107.1 - 8.3e-22 76.9 1.1 1.1e-21 76.5 0.8 1.1 1 0 0 1 1 1 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) Clc-like PF07062.7 EWC44107.1 - 0.019 14.2 1.0 0.032 13.4 0.7 1.2 1 0 0 1 1 1 0 Clc-like SAP30_Sin3_bdg PF13867.1 EWC44108.1 - 4.5e-10 39.2 0.1 6.7e-10 38.6 0.1 1.3 1 0 0 1 1 1 1 Sin3 binding region of histone deacetylase complex subunit SAP30 FAP PF07174.6 EWC44108.1 - 0.26 10.5 16.4 0.31 10.2 11.4 1.1 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) Med3 PF11593.3 EWC44108.1 - 0.65 9.1 11.4 0.7 9.0 7.9 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Neisseria_TspB PF05616.8 EWC44108.1 - 3.3 5.9 9.4 4.3 5.5 6.5 1.1 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein Xan_ur_permease PF00860.15 EWC44109.1 - 1.8e-65 220.9 30.9 1.3e-63 214.8 21.4 2.1 1 1 0 1 1 1 1 Permease family Phage_glycop_gL PF11108.3 EWC44109.1 - 0.13 12.2 0.4 0.26 11.2 0.0 1.6 2 0 0 2 2 2 0 Viral glycoprotein L FA_desaturase PF00487.19 EWC44110.1 - 7e-17 61.7 11.9 7e-17 61.7 8.3 2.0 1 1 1 2 2 2 1 Fatty acid desaturase Cyt-b5 PF00173.23 EWC44110.1 - 9.5e-16 57.3 0.1 3e-15 55.7 0.0 1.9 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain CTDII PF01556.13 EWC44111.1 - 1.8e-27 95.0 1.0 2.2e-20 72.2 0.1 3.3 3 0 0 3 3 3 2 DnaJ C terminal domain DnaJ PF00226.26 EWC44111.1 - 1.1e-24 85.9 3.6 1.1e-24 85.9 2.5 2.3 2 0 0 2 2 2 1 DnaJ domain DnaJ_CXXCXGXG PF00684.14 EWC44111.1 - 4.9e-10 39.3 18.4 9.5e-10 38.3 12.8 1.5 1 0 0 1 1 1 1 DnaJ central domain YcbB PF08664.5 EWC44111.1 - 0.11 12.2 0.7 14 5.4 0.1 2.2 2 0 0 2 2 2 0 YcbB domain HypA PF01155.14 EWC44111.1 - 3.4 7.3 5.9 39 3.9 0.5 2.4 1 1 1 2 2 2 0 Hydrogenase expression/synthesis hypA family CUE PF02845.11 EWC44112.1 - 1.1e-06 27.9 0.0 1.8e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 CUE domain WD40 PF00400.27 EWC44113.1 - 9.8e-53 174.2 20.4 2.2e-10 39.9 1.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat Apc4_WD40 PF12894.2 EWC44113.1 - 6.4e-10 38.3 0.1 0.0027 17.1 0.0 4.6 5 0 0 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain IKI3 PF04762.7 EWC44113.1 - 0.001 17.0 2.9 0.0078 14.0 0.3 2.3 2 1 0 2 2 2 2 IKI3 family SH3_2 PF07653.12 EWC44113.1 - 0.017 14.6 0.6 0.17 11.3 0.0 2.6 3 0 0 3 3 3 0 Variant SH3 domain Coatomer_WDAD PF04053.9 EWC44113.1 - 0.24 10.1 6.7 0.81 8.4 0.6 2.5 2 1 1 3 3 3 0 Coatomer WD associated region Proteasome PF00227.21 EWC44114.1 - 8.1e-37 126.3 0.0 1e-36 126.0 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit DUF3137 PF11335.3 EWC44114.1 - 0.038 13.6 0.1 0.059 13.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3137) Peptidase_M3 PF01432.15 EWC44115.1 - 2.1e-150 501.7 0.0 3.1e-150 501.2 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M3 EF-hand_9 PF14658.1 EWC44116.1 - 4.3e-13 48.9 0.0 2.2e-08 33.8 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 EWC44116.1 - 1.4e-11 44.3 0.0 1.4e-07 31.4 0.0 2.2 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 EWC44116.1 - 1.7e-10 39.8 0.3 0.00055 19.5 0.0 3.6 4 1 0 4 4 4 2 EF-hand domain EF-hand_1 PF00036.27 EWC44116.1 - 3.6e-10 38.3 0.4 0.00026 20.0 0.0 4.1 5 0 0 5 5 5 2 EF hand EF-hand_8 PF13833.1 EWC44116.1 - 4.6e-06 26.1 0.4 0.00017 21.1 0.0 3.2 3 1 1 4 4 4 1 EF-hand domain pair EF-hand_5 PF13202.1 EWC44116.1 - 0.00062 18.9 0.0 0.44 9.9 0.0 2.6 2 0 0 2 2 2 2 EF hand CDC45 PF02724.9 EWC44117.1 - 0.0045 15.0 4.2 0.0054 14.8 2.9 1.1 1 0 0 1 1 1 1 CDC45-like protein Myc_N PF01056.13 EWC44117.1 - 0.031 13.4 2.8 0.047 12.8 1.9 1.2 1 0 0 1 1 1 0 Myc amino-terminal region DUF2722 PF10846.3 EWC44117.1 - 0.087 11.8 1.2 0.085 11.8 0.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Daxx PF03344.10 EWC44117.1 - 0.55 8.6 11.1 0.91 7.9 7.7 1.3 1 0 0 1 1 1 0 Daxx Family CobT PF06213.7 EWC44117.1 - 5.9 5.9 15.0 10 5.1 10.4 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Peptidase_M28 PF04389.12 EWC44118.1 - 3.5e-28 98.5 0.0 6.4e-28 97.6 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.23 EWC44118.1 - 6.2e-07 29.1 0.0 1e-06 28.3 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 CoA_binding_2 PF13380.1 EWC44121.1 - 3e-30 104.7 0.1 3.4e-30 104.5 0.0 1.0 1 0 0 1 1 1 1 CoA binding domain DUF362 PF04015.7 EWC44121.1 - 0.004 16.6 0.0 0.0053 16.2 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF362) DUF2611 PF11022.3 EWC44122.1 - 9.6e-17 60.8 0.1 1e-16 60.7 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2611) MTP18 PF10558.4 EWC44123.1 - 2.2e-63 212.6 0.1 2.6e-63 212.3 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial 18 KDa protein (MTP18) Chitin_synth_1 PF01644.12 EWC44124.1 - 1.2e-85 285.2 0.1 2.1e-85 284.5 0.0 1.4 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.6 EWC44124.1 - 8.7e-30 102.2 0.3 2e-29 101.1 0.2 1.6 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.10 EWC44124.1 - 2.1e-23 82.5 3.1 5e-19 68.0 0.0 2.3 2 0 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.1 EWC44124.1 - 2.1e-08 34.1 0.3 2.1e-08 34.1 0.2 1.9 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.1 EWC44124.1 - 0.00046 20.0 0.0 0.0012 18.7 0.0 1.6 2 0 0 2 2 2 1 Glycosyltransferase like family 2 CDC45 PF02724.9 EWC44124.1 - 6 4.7 10.9 8.9 4.2 7.6 1.2 1 0 0 1 1 1 0 CDC45-like protein NOA36 PF06524.7 EWC44124.1 - 9.7 5.3 13.0 16 4.6 9.0 1.3 1 0 0 1 1 1 0 NOA36 protein AFG1_ATPase PF03969.11 EWC44125.1 - 4e-91 305.5 0.1 8.2e-87 291.3 0.0 2.9 3 0 0 3 3 3 2 AFG1-like ATPase AAA_16 PF13191.1 EWC44125.1 - 2.2e-05 24.5 0.1 0.3 11.0 0.0 3.0 2 1 1 3 3 3 2 AAA ATPase domain AAA_22 PF13401.1 EWC44125.1 - 0.0037 17.4 0.1 0.022 14.8 0.0 2.1 1 1 0 1 1 1 1 AAA domain Bac_DnaA PF00308.13 EWC44125.1 - 0.0063 16.1 0.1 0.11 12.1 0.1 2.3 2 1 0 2 2 2 1 Bacterial dnaA protein AAA_5 PF07728.9 EWC44125.1 - 0.015 14.9 0.0 0.029 14.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA PF00004.24 EWC44125.1 - 0.034 14.3 0.0 0.082 13.1 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.7 EWC44125.1 - 0.045 13.3 0.1 0.3 10.7 0.0 2.5 2 1 0 2 2 2 0 NACHT domain FKBP_C PF00254.23 EWC44127.1 - 2.7e-33 113.8 0.0 3.1e-33 113.6 0.0 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase MoCo_carrier PF12694.2 EWC44127.1 - 0.11 11.8 0.0 0.29 10.5 0.0 1.6 1 1 1 2 2 2 0 Putative molybdenum carrier TGT PF01702.13 EWC44128.1 - 2.5e-91 305.1 0.0 2.9e-91 304.9 0.0 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase Ribosomal_S17e PF00833.13 EWC44129.1 - 6e-57 190.6 0.4 7.2e-57 190.4 0.3 1.0 1 0 0 1 1 1 1 Ribosomal S17 Cryptochrome_C PF12546.3 EWC44129.1 - 0.032 14.9 0.0 0.044 14.4 0.0 1.2 1 0 0 1 1 1 0 Blue/Ultraviolet sensing protein C terminal Adaptin_N PF01602.15 EWC44130.1 - 1.2e-129 432.9 2.3 1.6e-129 432.6 1.6 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.2 EWC44130.1 - 2.1e-19 70.0 1.0 3.5e-18 66.0 0.0 3.0 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.1 EWC44130.1 - 3.6e-15 56.0 4.9 2.2e-10 40.6 0.3 4.4 3 1 2 5 5 5 3 HEAT repeats HEAT PF02985.17 EWC44130.1 - 1.6e-11 43.2 2.9 0.033 14.2 0.0 5.1 4 0 0 4 4 4 3 HEAT repeat HEAT_EZ PF13513.1 EWC44130.1 - 1.7e-05 25.1 10.7 0.021 15.3 0.1 6.2 4 2 1 5 5 5 2 HEAT-like repeat Atx10homo_assoc PF09759.4 EWC44130.1 - 0.0027 17.4 0.0 5.6 6.7 0.0 4.3 3 1 0 4 4 4 1 Spinocerebellar ataxia type 10 protein domain Arm PF00514.18 EWC44130.1 - 0.0028 17.4 4.4 2.8 7.9 0.0 4.5 4 0 0 4 4 4 2 Armadillo/beta-catenin-like repeat CLASP_N PF12348.3 EWC44130.1 - 0.0066 15.8 0.5 1.7 7.9 0.1 3.1 2 1 0 2 2 2 1 CLASP N terminal AF0941-like PF14591.1 EWC44130.1 - 0.094 12.7 1.0 0.23 11.5 0.7 1.6 1 0 0 1 1 1 0 AF0941-like DUF1077 PF06417.7 EWC44131.1 - 5.5e-47 158.2 1.2 7.1e-47 157.8 0.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) HR_lesion PF05514.6 EWC44131.1 - 0.027 14.3 0.1 0.036 13.9 0.1 1.2 1 0 0 1 1 1 0 HR-like lesion-inducing Rad4 PF03835.10 EWC44132.1 - 2e-29 101.8 0.1 4.1e-29 100.8 0.1 1.5 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain BHD_3 PF10405.4 EWC44132.1 - 3e-23 81.3 0.0 6.1e-23 80.3 0.0 1.6 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BHD_1 PF10403.4 EWC44132.1 - 1.1e-16 60.1 0.0 2.4e-16 58.9 0.0 1.6 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 BHD_2 PF10404.4 EWC44132.1 - 1e-14 54.5 0.1 2.7e-14 53.2 0.0 1.8 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 2 Transglut_core PF01841.14 EWC44132.1 - 0.00024 21.3 0.0 0.00072 19.7 0.0 1.9 1 0 0 1 1 1 1 Transglutaminase-like superfamily EAP30 PF04157.11 EWC44133.1 - 5.2e-49 166.4 0.4 6.6e-49 166.0 0.3 1.1 1 0 0 1 1 1 1 EAP30/Vps36 family Vps36_ESCRT-II PF11605.3 EWC44133.1 - 4.7e-26 90.4 0.0 9.5e-26 89.4 0.0 1.5 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 zf-Sec23_Sec24 PF04810.10 EWC44133.1 - 0.00018 20.9 6.2 0.00076 18.9 0.7 2.6 2 0 0 2 2 2 1 Sec23/Sec24 zinc finger LUC7 PF03194.10 EWC44133.1 - 0.00077 19.0 0.3 0.0016 18.0 0.0 1.6 2 0 0 2 2 2 1 LUC7 N_terminus GRAM PF02893.15 EWC44133.1 - 0.0014 18.0 0.0 0.003 17.0 0.0 1.4 1 0 0 1 1 1 1 GRAM domain zf-RanBP PF00641.13 EWC44133.1 - 0.0015 17.6 4.8 0.42 9.7 0.1 2.7 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others zf-MIZ PF02891.15 EWC44133.1 - 0.096 12.2 1.8 0.42 10.1 0.4 2.5 2 0 0 2 2 2 0 MIZ/SP-RING zinc finger Spt4 PF06093.8 EWC44133.1 - 0.12 12.2 0.3 0.35 10.7 0.2 1.8 1 0 0 1 1 1 0 Spt4/RpoE2 zinc finger DZR PF12773.2 EWC44133.1 - 1.7 8.5 7.9 0.52 10.1 0.8 2.3 1 1 2 3 3 3 0 Double zinc ribbon Ran_BP1 PF00638.13 EWC44134.1 - 1.1e-14 54.5 0.5 2.3e-13 50.2 0.3 2.5 1 1 1 2 2 2 1 RanBP1 domain cobW PF02492.14 EWC44135.1 - 1.6e-41 141.6 0.3 4.6e-41 140.1 0.2 1.7 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.9 EWC44135.1 - 7.4e-05 22.3 0.0 0.00013 21.5 0.0 1.4 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain AAA_16 PF13191.1 EWC44135.1 - 0.00013 22.0 0.0 0.00027 20.9 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain Arch_ATPase PF01637.13 EWC44135.1 - 0.0024 17.5 0.2 0.008 15.9 0.0 1.8 2 0 0 2 2 2 1 Archaeal ATPase AAA_22 PF13401.1 EWC44135.1 - 0.0028 17.7 0.2 0.013 15.6 0.0 2.0 2 0 0 2 2 2 1 AAA domain ArgK PF03308.11 EWC44135.1 - 0.0068 15.2 0.2 2.4 6.8 0.0 3.1 3 0 0 3 3 3 1 ArgK protein AAA_18 PF13238.1 EWC44135.1 - 0.0094 16.2 0.1 0.092 13.0 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.1 EWC44135.1 - 0.014 15.2 0.0 0.05 13.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain MobB PF03205.9 EWC44135.1 - 0.014 15.0 0.0 0.1 12.2 0.0 2.2 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_10 PF12846.2 EWC44135.1 - 0.02 14.3 0.0 0.033 13.6 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain T2SE PF00437.15 EWC44135.1 - 0.024 13.5 0.0 0.069 12.0 0.0 1.6 2 0 0 2 2 2 0 Type II/IV secretion system protein DUF258 PF03193.11 EWC44135.1 - 0.026 13.7 0.2 0.11 11.6 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function, DUF258 Zeta_toxin PF06414.7 EWC44135.1 - 0.027 13.5 0.0 0.043 12.9 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin GTP_EFTU PF00009.22 EWC44135.1 - 0.028 13.8 0.1 7.4 5.9 0.0 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 EWC44135.1 - 0.031 14.2 0.1 0.091 12.7 0.1 2.0 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_19 PF13245.1 EWC44135.1 - 0.037 13.7 0.0 0.1 12.3 0.0 1.7 1 0 0 1 1 1 0 Part of AAA domain ABC_tran PF00005.22 EWC44135.1 - 0.097 12.9 0.0 0.23 11.7 0.0 1.6 1 0 0 1 1 1 0 ABC transporter AAA_23 PF13476.1 EWC44135.1 - 0.098 12.9 0.0 0.21 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.10 EWC44135.1 - 0.11 12.1 0.2 0.29 10.8 0.1 1.7 1 0 0 1 1 1 0 NTPase NACHT PF05729.7 EWC44135.1 - 0.12 12.0 0.1 0.39 10.3 0.1 1.8 1 1 0 1 1 1 0 NACHT domain Choline_transpo PF04515.7 EWC44136.1 - 2.3e-100 335.6 23.2 2.3e-100 335.6 16.1 2.0 2 0 0 2 2 2 1 Plasma-membrane choline transporter Glyoxal_oxid_N PF07250.6 EWC44136.1 - 2.4e-44 151.2 0.0 4.6e-43 147.0 0.0 2.8 2 2 0 2 2 2 1 Glyoxal oxidase N-terminus DUF1929 PF09118.6 EWC44136.1 - 2.2e-11 43.6 0.1 4.8e-11 42.6 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1929) Chitin_bind_1 PF00187.14 EWC44136.1 - 0.01 15.7 8.8 0.025 14.5 6.1 1.7 1 0 0 1 1 1 0 Chitin recognition protein Kelch_4 PF13418.1 EWC44136.1 - 0.039 13.7 3.3 3.8 7.3 0.0 4.4 4 0 0 4 4 4 0 Galactose oxidase, central domain Peptidase_C37 PF05416.7 EWC44137.1 - 0.087 11.1 0.0 0.12 10.6 0.0 1.1 1 0 0 1 1 1 0 Southampton virus-type processing peptidase DUF3761 PF12587.3 EWC44137.1 - 1 9.4 6.6 11 6.2 0.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3761) G-patch PF01585.18 EWC44138.1 - 8e-12 44.7 0.6 8e-12 44.7 0.4 1.7 2 0 0 2 2 2 1 G-patch domain zf-RanBP PF00641.13 EWC44138.1 - 7.4e-10 37.7 1.1 1.3e-09 36.9 0.7 1.5 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others RRM_1 PF00076.17 EWC44138.1 - 3e-08 33.1 0.2 1.6e-07 30.8 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) G-patch_2 PF12656.2 EWC44138.1 - 2.4e-06 27.3 0.9 8.9e-06 25.4 0.6 2.0 1 0 0 1 1 1 1 DExH-box splicing factor binding site RRM_6 PF14259.1 EWC44138.1 - 5.7e-05 23.0 0.0 0.00011 22.0 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EWC44138.1 - 0.006 16.4 0.0 0.012 15.4 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Rad50_zn_hook PF04423.9 EWC44138.1 - 0.063 12.7 0.5 0.25 10.8 0.4 2.0 1 0 0 1 1 1 0 Rad50 zinc hook motif RED_N PF07808.8 EWC44138.1 - 2.3 7.3 11.8 0.02 14.1 2.7 1.5 2 0 0 2 2 2 0 RED-like protein N-terminal region zf-met PF12874.2 EWC44138.1 - 2.8 8.2 6.0 0.79 10.0 0.6 2.3 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.1 EWC44138.1 - 4.6 7.7 11.8 0.18 12.2 0.8 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger Kelch_5 PF13854.1 EWC44139.1 - 1.6e-07 31.1 11.2 0.0017 18.2 0.3 4.9 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.10 EWC44139.1 - 0.0068 16.1 3.2 6.3 6.7 0.0 4.7 6 0 0 6 6 6 1 Kelch motif Kelch_6 PF13964.1 EWC44139.1 - 0.015 15.4 11.8 3.1 8.1 0.1 5.0 5 0 0 5 5 5 0 Kelch motif EphA2_TM PF14575.1 EWC44139.1 - 0.037 14.4 0.1 0.068 13.5 0.1 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Kelch_1 PF01344.20 EWC44139.1 - 0.18 11.3 3.1 4.8 6.7 0.0 4.3 5 0 0 5 5 5 0 Kelch motif Kelch_3 PF13415.1 EWC44139.1 - 0.4 10.9 15.8 8 6.7 0.0 5.7 6 0 0 6 6 6 0 Galactose oxidase, central domain Coatomer_WDAD PF04053.9 EWC44141.1 - 1.9e-170 567.4 0.0 3.1e-170 566.7 0.0 1.3 1 0 0 1 1 1 1 Coatomer WD associated region WD40 PF00400.27 EWC44141.1 - 8.6e-46 152.2 9.8 6.6e-11 41.6 0.2 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat BBS2_Mid PF14783.1 EWC44141.1 - 0.00021 21.0 0.0 0.21 11.4 0.0 4.0 3 1 0 3 3 3 1 Ciliary BBSome complex subunit 2, middle region Nup160 PF11715.3 EWC44141.1 - 0.0019 16.4 3.3 0.13 10.3 0.1 3.2 1 1 2 3 3 3 2 Nucleoporin Nup120/160 DUF2457 PF10446.4 EWC44141.1 - 4.4 5.9 10.1 6.1 5.4 7.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) GPI2 PF06432.6 EWC44142.1 - 5.9e-61 206.2 0.0 7.6e-61 205.9 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase ABC1 PF03109.11 EWC44143.1 - 1.7e-25 89.2 0.0 3.3e-25 88.3 0.0 1.5 1 0 0 1 1 1 1 ABC1 family Shugoshin_C PF07557.6 EWC44143.1 - 0.6 9.6 3.3 13 5.3 0.0 3.3 3 0 0 3 3 3 0 Shugoshin C terminus SCO1-SenC PF02630.9 EWC44144.1 - 1.1e-57 194.3 0.0 1.5e-57 193.9 0.0 1.1 1 0 0 1 1 1 1 SCO1/SenC AhpC-TSA PF00578.16 EWC44144.1 - 2.2e-05 24.1 0.0 3.8e-05 23.3 0.0 1.4 1 1 0 1 1 1 1 AhpC/TSA family Thioredoxin_8 PF13905.1 EWC44144.1 - 0.0042 17.1 0.0 0.011 15.8 0.0 1.7 1 1 0 1 1 1 1 Thioredoxin-like Redoxin PF08534.5 EWC44144.1 - 0.13 11.8 0.1 1.4 8.4 0.0 2.1 1 1 0 1 1 1 0 Redoxin SNARE PF05739.14 EWC44145.1 - 6.4e-17 61.0 3.6 7.6e-17 60.7 0.1 2.7 3 0 0 3 3 3 1 SNARE domain Syntaxin PF00804.20 EWC44145.1 - 7.1e-17 61.4 5.6 1.4e-16 60.4 0.0 2.6 3 0 0 3 3 3 1 Syntaxin Sed5p PF11416.3 EWC44145.1 - 0.0056 16.0 0.6 0.011 15.1 0.4 1.6 1 0 0 1 1 1 1 Integral membrane protein Sed5p Syntaxin-18_N PF10496.4 EWC44145.1 - 0.0096 15.7 0.2 0.071 12.9 0.0 2.4 2 0 0 2 2 2 1 SNARE-complex protein Syntaxin-18 N-terminus XPC-binding PF09280.6 EWC44145.1 - 0.037 13.4 2.3 1.6 8.2 0.1 2.5 2 0 0 2 2 2 0 XPC-binding domain ApoLp-III PF07464.6 EWC44145.1 - 0.13 12.2 1.9 9.5 6.2 0.2 2.4 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) NPV_P10 PF05531.7 EWC44145.1 - 0.8 9.9 5.2 26 5.1 0.1 3.4 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein CorA PF01544.13 EWC44147.1 - 2.4e-09 36.6 0.0 4.8e-09 35.6 0.0 1.4 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein HK97-gp10_like PF04883.7 EWC44147.1 - 0.56 11.1 2.6 28 5.7 0.0 3.7 4 1 0 4 4 4 0 Bacteriophage HK97-gp10, putative tail-component Arf PF00025.16 EWC44149.1 - 2.4e-80 267.8 0.1 2.7e-80 267.7 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.5 EWC44149.1 - 2e-14 53.2 0.0 2.5e-14 52.9 0.0 1.0 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.17 EWC44149.1 - 1e-13 51.0 0.0 1.2e-13 50.8 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.15 EWC44149.1 - 2e-12 46.5 1.4 3.7e-09 35.7 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.7 EWC44149.1 - 2.3e-11 43.2 0.0 2.7e-11 43.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Miro PF08477.8 EWC44149.1 - 2.2e-09 37.8 0.0 3e-09 37.4 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 EWC44149.1 - 4.8e-06 26.5 0.0 6.6e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 EWC44149.1 - 0.0033 16.8 0.1 0.029 13.8 0.0 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain 6PF2K PF01591.13 EWC44149.1 - 0.0067 15.5 0.5 0.014 14.4 0.3 1.7 1 1 0 1 1 1 1 6-phosphofructo-2-kinase AAA_33 PF13671.1 EWC44149.1 - 0.059 13.2 0.3 0.15 11.9 0.2 1.9 1 1 0 1 1 1 0 AAA domain PduV-EutP PF10662.4 EWC44149.1 - 0.13 11.7 0.3 2.4 7.6 0.1 2.2 1 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Choline_kinase PF01633.15 EWC44150.1 - 1.6e-42 145.4 0.0 1.9e-41 141.9 0.0 2.1 2 0 0 2 2 2 1 Choline/ethanolamine kinase APH PF01636.18 EWC44150.1 - 9e-06 25.5 0.0 2.3e-05 24.2 0.0 1.7 1 1 0 1 1 1 1 Phosphotransferase enzyme family adh_short_C2 PF13561.1 EWC44151.1 - 9.5e-24 84.4 0.1 1.1e-23 84.2 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 EWC44151.1 - 3e-12 46.7 1.0 5.1e-12 46.0 0.4 1.6 1 1 1 2 2 2 1 short chain dehydrogenase KR PF08659.5 EWC44151.1 - 1.9e-06 27.6 0.5 3.5e-06 26.8 0.1 1.5 2 0 0 2 2 2 1 KR domain Eno-Rase_NADH_b PF12242.3 EWC44151.1 - 0.019 14.7 0.2 0.056 13.2 0.2 1.8 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase 3HCDH_N PF02737.13 EWC44151.1 - 0.1 12.2 0.4 0.28 10.7 0.0 1.8 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF3405 PF11885.3 EWC44152.1 - 6.6e-113 377.5 1.2 8.9e-113 377.1 0.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3405) SpoU_methylase PF00588.14 EWC44153.1 - 5e-24 84.7 0.0 9e-24 83.9 0.0 1.4 1 0 0 1 1 1 1 SpoU rRNA Methylase family SpoU_sub_bind PF08032.7 EWC44153.1 - 6.3e-06 26.2 0.0 6.3e-06 26.2 0.0 2.3 2 0 0 2 2 2 1 RNA 2'-O ribose methyltransferase substrate binding DSBA PF01323.15 EWC44153.1 - 0.016 14.7 1.0 0.063 12.8 0.0 2.2 2 0 0 2 2 2 0 DSBA-like thioredoxin domain Recep_L_domain PF01030.19 EWC44154.1 - 3.4e-11 43.1 0.4 0.00016 21.6 0.0 4.1 2 1 2 4 4 4 4 Receptor L domain Glycophorin_A PF01102.13 EWC44154.1 - 0.027 14.2 0.0 0.053 13.2 0.0 1.4 1 0 0 1 1 1 0 Glycophorin A SNF2_N PF00176.18 EWC44155.1 - 4.3e-59 199.7 0.1 6.4e-59 199.1 0.1 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain zf-PHD-like PF15446.1 EWC44155.1 - 3.5e-50 169.6 12.7 7.2e-50 168.6 8.8 1.5 1 0 0 1 1 1 1 PHD/FYVE-zinc-finger like domain Helicase_C PF00271.26 EWC44155.1 - 8.3e-13 48.0 0.0 2.6e-12 46.4 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain PHD PF00628.24 EWC44155.1 - 6.1e-05 22.6 12.8 0.00077 19.1 3.5 3.2 2 2 0 2 2 2 2 PHD-finger DEAD PF00270.24 EWC44155.1 - 0.00043 19.8 0.0 0.0011 18.5 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase PHD_2 PF13831.1 EWC44155.1 - 0.0036 16.5 3.3 0.0036 16.5 2.3 3.6 3 1 0 3 3 3 1 PHD-finger Chromo PF00385.19 EWC44155.1 - 0.035 13.7 2.4 0.76 9.4 0.0 3.2 3 0 0 3 3 3 0 Chromo (CHRromatin Organisation MOdifier) domain C1_1 PF00130.17 EWC44155.1 - 0.26 11.0 9.6 0.13 12.0 2.0 2.8 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) MRP-S28 PF10213.4 EWC44156.1 - 1.8e-41 141.2 0.3 3.6e-41 140.2 0.2 1.5 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit protein Glyco_tran_28_C PF04101.11 EWC44157.1 - 1.4e-22 80.1 0.1 1.7e-22 79.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_1_3 PF13528.1 EWC44157.1 - 2.5e-07 30.2 0.0 2.9e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 1 Btz PF09405.5 EWC44158.1 - 6.1e-23 81.2 9.4 6.1e-23 81.2 6.5 2.2 2 1 0 2 2 2 1 CASC3/Barentsz eIF4AIII binding Glyco_hydro_72 PF03198.9 EWC44160.1 - 7.5e-128 425.9 0.7 9.1e-128 425.6 0.5 1.0 1 0 0 1 1 1 1 Glucanosyltransferase Cellulase PF00150.13 EWC44160.1 - 0.00019 20.7 0.2 0.00034 19.9 0.1 1.3 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) DUF681 PF05080.7 EWC44160.1 - 0.03 14.7 0.0 0.08 13.3 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF681) Glyco_hydro_114 PF03537.8 EWC44161.1 - 1.6e-17 63.0 0.1 2.8e-17 62.2 0.1 1.4 1 0 0 1 1 1 1 Glycoside-hydrolase family GH114 Lactamase_B_2 PF12706.2 EWC44162.1 - 2.7e-38 131.4 0.1 3.5e-38 131.1 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.1 EWC44162.1 - 1.8e-11 43.9 0.0 3.1e-11 43.2 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.22 EWC44162.1 - 0.00024 20.7 2.9 0.028 14.0 1.0 2.9 2 1 0 2 2 2 2 Metallo-beta-lactamase superfamily Terpene_synth_C PF03936.11 EWC44164.1 - 0.16 11.1 0.6 0.34 10.0 0.3 1.5 2 0 0 2 2 2 0 Terpene synthase family, metal binding domain NmrA PF05368.8 EWC44165.1 - 0.011 14.9 0.0 0.023 13.9 0.0 1.6 1 1 0 1 1 1 0 NmrA-like family Fungal_trans PF04082.13 EWC44167.1 - 9.2e-38 129.5 0.3 2.2e-37 128.3 0.1 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EWC44167.1 - 7.7e-10 38.5 11.8 1.3e-09 37.8 8.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.11 EWC44168.1 - 6.7e-18 64.5 39.9 8.4e-18 64.1 27.7 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF2363 PF10155.4 EWC44169.1 - 1.2e-07 31.7 0.5 2.6e-06 27.4 0.5 2.6 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2363) Pmp3 PF01679.12 EWC44170.1 - 5e-26 90.1 6.0 5.4e-26 90.0 4.1 1.0 1 0 0 1 1 1 1 Proteolipid membrane potential modulator Ribosomal_L22e PF01776.12 EWC44172.1 - 6.1e-48 161.4 0.4 7e-48 161.2 0.3 1.0 1 0 0 1 1 1 1 Ribosomal L22e protein family Transketolase_N PF00456.16 EWC44173.1 - 2.4e-150 499.9 0.0 3.1e-150 499.6 0.0 1.1 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.19 EWC44173.1 - 8e-48 162.2 0.0 1.3e-47 161.6 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.15 EWC44173.1 - 5.1e-14 52.2 0.0 1.7e-13 50.6 0.0 1.9 2 0 0 2 2 2 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.1 EWC44173.1 - 5.8e-08 32.0 0.0 2.6e-07 29.8 0.0 1.7 1 1 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase E1_dh PF00676.15 EWC44173.1 - 0.016 13.9 0.0 0.029 13.0 0.0 1.3 1 0 0 1 1 1 0 Dehydrogenase E1 component ACT_7 PF13840.1 EWC44173.1 - 0.084 12.3 0.1 0.21 11.1 0.0 1.7 1 0 0 1 1 1 0 ACT domain Anp1 PF03452.9 EWC44174.1 - 3e-106 354.5 0.0 3.7e-106 354.2 0.0 1.0 1 0 0 1 1 1 1 Anp1 p450 PF00067.17 EWC44175.1 - 1.8e-23 82.7 0.0 4e-23 81.6 0.0 1.5 1 1 0 1 1 1 1 Cytochrome P450 NAD_kinase PF01513.16 EWC44176.1 - 8.7e-72 241.2 0.0 1.1e-71 240.9 0.0 1.1 1 0 0 1 1 1 1 ATP-NAD kinase AA_permease_2 PF13520.1 EWC44177.1 - 4.4e-64 216.5 54.1 5.3e-64 216.3 37.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EWC44177.1 - 2.8e-14 52.3 46.9 3.9e-14 51.8 32.5 1.2 1 0 0 1 1 1 1 Amino acid permease IlvGEDA_leader PF08046.6 EWC44177.1 - 7.9 5.7 8.7 11 5.2 0.8 3.2 3 0 0 3 3 3 0 IlvGEDA operon leader peptide Cu-oxidase PF00394.17 EWC44178.1 - 1.5e-34 119.2 0.0 3.9e-32 111.3 0.0 2.2 2 0 0 2 2 2 2 Multicopper oxidase Cu-oxidase_3 PF07732.10 EWC44178.1 - 2.7e-31 107.7 0.1 2.7e-31 107.7 0.1 2.2 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase_2 PF07731.9 EWC44178.1 - 9.7e-19 67.2 10.0 4.1e-17 61.9 1.0 3.4 3 1 0 3 3 3 2 Multicopper oxidase Ribosomal_L7Ae PF01248.21 EWC44179.1 - 2.8e-18 65.1 0.3 2e-12 46.4 0.0 2.3 2 0 0 2 2 2 2 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family SR-25 PF10500.4 EWC44179.1 - 0.0013 18.3 24.7 0.0013 18.3 17.1 2.7 3 0 0 3 3 3 1 Nuclear RNA-splicing-associated protein Ycf1 PF05758.7 EWC44179.1 - 0.022 12.5 4.6 0.021 12.5 3.2 1.1 1 0 0 1 1 1 0 Ycf1 Ebola_NP PF05505.7 EWC44179.1 - 0.78 7.7 9.2 0.91 7.5 6.4 1.1 1 0 0 1 1 1 0 Ebola nucleoprotein Tim54 PF11711.3 EWC44179.1 - 2.6 6.5 11.2 3.2 6.2 7.7 1.4 1 1 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 SAPS PF04499.10 EWC44179.1 - 4.1 5.9 9.1 5.4 5.5 6.3 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Paramyxo_ncap PF00973.14 EWC44179.1 - 4.2 5.9 7.5 5.4 5.5 5.2 1.2 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein CDC45 PF02724.9 EWC44179.1 - 4.6 5.1 11.5 6.6 4.6 8.0 1.3 1 0 0 1 1 1 0 CDC45-like protein Daxx PF03344.10 EWC44179.1 - 6.5 5.1 17.3 0.58 8.5 8.5 1.7 2 0 0 2 2 2 0 Daxx Family PTPA PF03095.10 EWC44180.1 - 1.7e-106 355.7 0.0 2e-106 355.5 0.0 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein RNase_PH PF01138.16 EWC44181.1 - 4e-15 56.2 0.0 6.1e-15 55.6 0.0 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 Glyco_hydro_75 PF07335.6 EWC44182.1 - 1.9e-35 122.0 0.0 2.6e-35 121.6 0.0 1.2 1 0 0 1 1 1 1 Fungal chitosanase of glycosyl hydrolase group 75 TIMELESS PF04821.9 EWC44183.1 - 2.7e-57 194.0 0.0 1.2e-56 191.8 0.0 1.9 2 0 0 2 2 2 1 Timeless protein TIMELESS_C PF05029.8 EWC44183.1 - 2.5e-11 43.2 8.2 2.4e-10 39.9 5.7 2.1 1 1 0 1 1 1 1 Timeless protein C terminal region BPL_N PF09825.4 EWC44184.1 - 1.1e-110 369.8 0.0 1.5e-110 369.4 0.0 1.1 1 0 0 1 1 1 1 Biotin-protein ligase, N terminal BPL_LplA_LipB PF03099.14 EWC44184.1 - 1.9e-20 73.1 0.0 3.1e-20 72.4 0.0 1.4 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family BPL_C PF02237.12 EWC44184.1 - 4.6e-06 26.2 0.1 1.1e-05 25.0 0.0 1.7 1 0 0 1 1 1 1 Biotin protein ligase C terminal domain CRS1_YhbY PF01985.16 EWC44184.1 - 0.17 11.9 0.1 0.49 10.4 0.0 1.7 1 0 0 1 1 1 0 CRS1 / YhbY (CRM) domain Pkinase PF00069.20 EWC44185.1 - 1.3e-52 178.5 0.0 3.6e-52 177.1 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC44185.1 - 8.1e-23 80.8 0.0 1.6e-22 79.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 EWC44185.1 - 0.00078 19.2 0.0 0.0016 18.2 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.17 EWC44185.1 - 0.002 17.4 0.3 0.0071 15.7 0.2 1.8 1 1 0 1 1 1 1 RIO1 family DUF4430 PF14478.1 EWC44185.1 - 0.094 12.7 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4430) Paf67 PF10255.4 EWC44186.1 - 2.5e-149 497.5 0.1 2.9e-149 497.3 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase I-associated factor PAF67 TPR_2 PF07719.12 EWC44186.1 - 0.00023 20.8 0.0 0.00098 18.8 0.0 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.23 EWC44186.1 - 0.00025 20.5 0.0 0.00099 18.6 0.0 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.1 EWC44186.1 - 0.00075 19.3 0.1 0.086 12.7 0.0 2.1 1 1 1 2 2 2 2 Tetratricopeptide repeat Apc3 PF12895.2 EWC44186.1 - 0.012 15.6 0.0 0.043 13.9 0.0 2.0 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.1 EWC44186.1 - 0.016 14.8 0.1 0.041 13.5 0.0 1.7 1 0 0 1 1 1 0 TPR repeat TPR_19 PF14559.1 EWC44186.1 - 0.021 15.1 0.0 18 5.7 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat NRDE PF05742.7 EWC44187.1 - 1.4e-13 50.7 0.0 2e-13 50.2 0.0 1.1 1 0 0 1 1 1 1 NRDE protein PCI PF01399.22 EWC44188.1 - 1.9e-13 50.6 0.0 2.9e-13 50.0 0.0 1.3 1 0 0 1 1 1 1 PCI domain eIF-3c_N PF05470.7 EWC44189.1 - 7.3e-91 305.0 9.6 7.3e-91 305.0 6.6 3.0 1 1 1 2 2 2 1 Eukaryotic translation initiation factor 3 subunit 8 N-terminus BAP PF06639.6 EWC44189.1 - 0.12 12.0 0.0 0.48 10.1 0.0 2.0 2 0 0 2 2 2 0 Basal layer antifungal peptide (BAP) DEAD PF00270.24 EWC44190.1 - 8.5e-47 158.7 0.0 3.8e-45 153.3 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EWC44190.1 - 1.7e-10 40.5 0.0 4.5e-10 39.2 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EWC44190.1 - 0.00016 21.5 0.0 0.0004 20.2 0.0 1.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Glyoxalase_3 PF13468.1 EWC44190.1 - 0.02 14.8 0.0 0.041 13.7 0.0 1.5 1 0 0 1 1 1 0 Glyoxalase-like domain Helicase_C_2 PF13307.1 EWC44190.1 - 0.08 12.8 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 Helicase C-terminal domain FAT PF02259.18 EWC44191.1 - 3.3e-134 447.3 0.1 3.3e-134 447.3 0.1 2.6 2 0 0 2 2 2 1 FAT domain DUF3385 PF11865.3 EWC44191.1 - 7.8e-62 207.9 4.3 4.8e-59 198.8 0.2 5.1 5 0 0 5 5 5 1 Domain of unknown function (DUF3385) PI3_PI4_kinase PF00454.22 EWC44191.1 - 1.2e-59 201.6 0.7 2.6e-59 200.5 0.5 1.6 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase Rapamycin_bind PF08771.6 EWC44191.1 - 2.4e-43 146.2 0.1 2.4e-43 146.2 0.0 2.7 3 0 0 3 3 3 1 Rapamycin binding domain HEAT_2 PF13646.1 EWC44191.1 - 1.1e-17 64.0 18.3 0.0015 18.7 0.1 9.4 5 3 5 10 10 10 7 HEAT repeats HEAT PF02985.17 EWC44191.1 - 6.8e-17 59.9 24.1 0.0057 16.6 0.0 11.2 11 0 0 11 11 11 5 HEAT repeat FATC PF02260.15 EWC44191.1 - 4.5e-15 54.7 0.5 1e-14 53.6 0.4 1.7 1 0 0 1 1 1 1 FATC domain HEAT_EZ PF13513.1 EWC44191.1 - 1.3e-13 50.9 29.0 2.1e-05 24.8 0.0 12.4 12 2 1 14 14 14 3 HEAT-like repeat CLASP_N PF12348.3 EWC44191.1 - 3e-06 26.7 6.3 3.2 7.0 0.0 6.6 5 3 0 6 6 6 1 CLASP N terminal UME PF08064.8 EWC44191.1 - 6.9e-05 22.7 10.2 2.4 8.1 0.5 7.0 5 2 2 7 7 7 2 UME (NUC010) domain AAA_11 PF13086.1 EWC44192.1 - 2.3e-22 79.7 0.0 5.7e-22 78.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_12 PF13087.1 EWC44192.1 - 5.5e-13 48.7 0.0 1.6e-12 47.2 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 EWC44192.1 - 9.5e-09 34.8 0.0 2.4e-08 33.6 0.0 1.6 1 0 0 1 1 1 1 Part of AAA domain AAA_30 PF13604.1 EWC44192.1 - 4e-05 23.2 0.0 0.0064 16.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain ResIII PF04851.10 EWC44192.1 - 0.00053 19.8 0.0 0.001 18.9 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_16 PF13191.1 EWC44192.1 - 0.0019 18.2 0.2 0.015 15.2 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain AAA PF00004.24 EWC44192.1 - 0.0029 17.7 0.0 0.013 15.6 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.1 EWC44192.1 - 0.004 16.5 0.0 0.0092 15.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain UvrD-helicase PF00580.16 EWC44192.1 - 0.032 13.5 0.0 0.12 11.6 0.0 1.9 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain AAA_22 PF13401.1 EWC44192.1 - 0.04 14.0 0.0 0.28 11.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.4 EWC44192.1 - 0.073 12.0 0.0 0.23 10.4 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) PIF1 PF05970.9 EWC44192.1 - 0.11 11.3 0.0 3.6 6.4 0.0 2.2 2 0 0 2 2 2 0 PIF1-like helicase Zeta_toxin PF06414.7 EWC44192.1 - 0.13 11.3 0.0 0.24 10.4 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin Snf7 PF03357.16 EWC44193.1 - 6.7e-19 67.9 12.3 7.9e-19 67.6 8.5 1.1 1 0 0 1 1 1 1 Snf7 Ist1 PF03398.9 EWC44193.1 - 0.001 18.4 2.0 0.0015 17.9 1.4 1.3 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway GrpE PF01025.14 EWC44193.1 - 0.021 14.3 3.7 0.031 13.8 2.6 1.4 1 0 0 1 1 1 0 GrpE COG5 PF10392.4 EWC44193.1 - 0.099 12.6 2.9 0.16 11.9 1.3 1.9 1 1 0 1 1 1 0 Golgi transport complex subunit 5 Peptidase_M75 PF09375.5 EWC44193.1 - 0.49 9.6 4.8 0.8 8.9 3.3 1.3 1 1 0 1 1 1 0 Imelysin DUF3708 PF12501.3 EWC44193.1 - 1.6 8.5 6.0 0.35 10.6 1.0 1.9 1 1 1 2 2 2 0 Phosphate ATP-binding cassette transporter PspA_IM30 PF04012.7 EWC44193.1 - 2.7 7.2 15.1 16 4.7 10.5 2.2 1 1 0 1 1 1 0 PspA/IM30 family Homeobox PF00046.24 EWC44194.1 - 3.5e-17 61.7 2.9 7.5e-17 60.7 2.0 1.6 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.6 EWC44194.1 - 0.084 12.5 0.1 0.084 12.5 0.1 2.6 2 0 0 2 2 2 0 Homeobox KN domain ADH_zinc_N PF00107.21 EWC44195.1 - 1.8e-06 27.5 0.0 2.5e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Amidase PF01425.16 EWC44196.1 - 4.1e-27 95.1 0.0 4.7e-27 94.9 0.0 1.0 1 0 0 1 1 1 1 Amidase BRICHOS PF04089.9 EWC44196.1 - 0.051 13.4 0.0 0.099 12.5 0.0 1.5 1 0 0 1 1 1 0 BRICHOS domain dCMP_cyt_deam_1 PF00383.17 EWC44197.1 - 2.4e-21 75.3 0.1 3.6e-21 74.7 0.1 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region Bd3614-deam PF14439.1 EWC44197.1 - 0.13 12.1 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 Bd3614-like deaminase PFK PF00365.15 EWC44198.1 - 2.9e-168 557.9 2.0 5.8e-120 399.5 1.4 2.1 2 0 0 2 2 2 2 Phosphofructokinase UVR PF02151.14 EWC44198.1 - 0.059 12.8 1.2 0.16 11.5 0.8 1.8 1 0 0 1 1 1 0 UvrB/uvrC motif TgMIC1 PF11476.3 EWC44198.1 - 0.16 11.4 0.8 2 7.9 0.0 2.3 2 0 0 2 2 2 0 Toxoplasma gondii micronemal protein 1 TgMIC1 Transket_pyr PF02779.19 EWC44199.1 - 2.2e-41 141.2 0.0 2.8e-40 137.7 0.0 2.0 1 1 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.15 EWC44199.1 - 2.7e-33 114.5 0.1 1.2e-32 112.5 0.0 2.1 2 0 0 2 2 2 1 Transketolase, C-terminal domain RRM_5 PF13893.1 EWC44200.1 - 6.8e-10 38.6 0.0 1.2e-09 37.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 EWC44200.1 - 9.1e-10 38.0 0.0 1.5e-09 37.3 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EWC44200.1 - 3.7e-05 23.6 0.0 6.1e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 EWC44200.1 - 0.0079 15.9 0.1 0.014 15.1 0.0 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.6 EWC44200.1 - 0.057 13.2 0.0 0.1 12.4 0.0 1.4 1 0 0 1 1 1 0 RNA binding motif API5 PF05918.6 EWC44200.1 - 0.2 10.1 0.3 0.27 9.6 0.2 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) Sterol_MT_C PF08498.5 EWC44201.1 - 2.8e-28 97.6 0.1 4.6e-28 96.9 0.1 1.4 1 0 0 1 1 1 1 Sterol methyltransferase C-terminal Methyltransf_11 PF08241.7 EWC44201.1 - 1.9e-18 66.7 0.0 4e-18 65.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EWC44201.1 - 2.5e-18 66.1 0.0 3.7e-18 65.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EWC44201.1 - 6.9e-13 48.6 0.0 1.3e-12 47.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 EWC44201.1 - 8.6e-13 47.9 0.0 1.2e-12 47.4 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_25 PF13649.1 EWC44201.1 - 8.4e-12 45.3 0.0 1.6e-11 44.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EWC44201.1 - 8.8e-12 45.5 0.0 3e-11 43.8 0.0 1.9 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EWC44201.1 - 3.1e-11 43.6 0.0 7.3e-11 42.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EWC44201.1 - 1.9e-09 37.5 0.0 6.3e-09 35.8 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EWC44201.1 - 9.1e-09 34.7 0.0 1.4e-08 34.1 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.9 EWC44201.1 - 4.8e-05 22.8 0.0 9.4e-05 21.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_3 PF01596.12 EWC44201.1 - 6.6e-05 22.0 0.0 0.0001 21.4 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_15 PF09445.5 EWC44201.1 - 0.00016 21.2 0.0 0.00023 20.7 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase PCMT PF01135.14 EWC44201.1 - 0.00044 19.8 0.0 0.00071 19.1 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) UPF0020 PF01170.13 EWC44201.1 - 0.015 14.8 0.0 0.026 14.1 0.0 1.3 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 PrmA PF06325.8 EWC44201.1 - 0.016 14.3 0.0 0.03 13.4 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) NodS PF05401.6 EWC44201.1 - 0.019 14.3 0.0 0.03 13.7 0.0 1.2 1 0 0 1 1 1 0 Nodulation protein S (NodS) Methyltransf_24 PF13578.1 EWC44201.1 - 0.036 14.9 0.0 0.13 13.1 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_32 PF13679.1 EWC44201.1 - 0.043 13.4 0.0 0.091 12.4 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain MetW PF07021.7 EWC44201.1 - 0.087 12.1 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW RrnaAD PF00398.15 EWC44201.1 - 0.17 10.9 0.0 0.27 10.2 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase DnaJ PF00226.26 EWC44202.1 - 7e-15 54.5 5.8 1.2e-12 47.4 0.2 3.3 3 0 0 3 3 3 2 DnaJ domain DUF2781 PF10914.3 EWC44203.1 - 3.4e-25 88.5 9.0 3.8e-25 88.4 6.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2781) EBP PF05241.7 EWC44203.1 - 0.0006 18.8 0.3 0.00097 18.1 0.2 1.3 1 0 0 1 1 1 1 Emopamil binding protein Nepo_coat_N PF03689.10 EWC44203.1 - 0.071 12.8 0.0 0.62 9.8 0.0 2.2 2 0 0 2 2 2 0 Nepovirus coat protein, N-terminal domain HTH_24 PF13412.1 EWC44203.1 - 0.14 11.5 0.0 0.34 10.3 0.0 1.6 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding Sec62 PF03839.11 EWC44203.1 - 0.77 9.1 4.3 1.5 8.2 0.1 2.1 2 0 0 2 2 2 0 Translocation protein Sec62 PI3_PI4_kinase PF00454.22 EWC44205.1 - 3.6e-52 177.1 0.0 7e-52 176.2 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.18 EWC44205.1 - 1e-26 93.7 0.2 1e-26 93.7 0.2 1.8 2 0 0 2 2 2 1 FAT domain UME PF08064.8 EWC44205.1 - 4.4e-25 87.6 0.0 3.3e-24 84.8 0.0 2.7 2 0 0 2 2 2 1 UME (NUC010) domain FATC PF02260.15 EWC44205.1 - 3.1e-17 61.6 0.3 1e-16 60.0 0.2 2.0 1 0 0 1 1 1 1 FATC domain ISN1 PF06437.6 EWC44206.1 - 1.7e-168 560.6 0.0 1.9e-168 560.4 0.0 1.0 1 0 0 1 1 1 1 IMP-specific 5'-nucleotidase Swi3 PF07962.7 EWC44207.1 - 4.7e-30 103.0 0.3 1.9e-29 101.0 0.0 2.0 2 0 0 2 2 2 1 Replication Fork Protection Component Swi3 DUF935 PF06074.7 EWC44207.1 - 0.023 13.4 3.0 0.042 12.5 2.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF935) Nnf1 PF03980.9 EWC44207.1 - 0.25 11.3 3.1 1.3 9.0 2.1 2.2 1 1 0 1 1 1 0 Nnf1 Adaptin_binding PF10199.4 EWC44207.1 - 5 7.4 10.9 14 5.9 7.3 2.0 1 1 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 FMN_dh PF01070.13 EWC44208.1 - 2.7e-121 404.7 0.4 3.4e-121 404.4 0.3 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.23 EWC44208.1 - 3.3e-23 81.2 0.0 5.8e-23 80.4 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.12 EWC44208.1 - 2.8e-08 33.1 0.2 4.3e-08 32.4 0.1 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase NMO PF03060.10 EWC44208.1 - 3.3e-06 26.4 0.2 5.6e-06 25.7 0.2 1.3 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.20 EWC44208.1 - 0.00014 20.8 0.7 0.00028 19.8 0.1 1.7 2 0 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain His_biosynth PF00977.16 EWC44208.1 - 0.0039 16.4 0.1 0.27 10.4 0.0 2.4 2 0 0 2 2 2 1 Histidine biosynthesis protein ThiG PF05690.9 EWC44208.1 - 0.048 12.7 0.2 0.5 9.3 0.0 2.1 2 0 0 2 2 2 0 Thiazole biosynthesis protein ThiG TFIIF_alpha PF05793.7 EWC44209.1 - 0.00031 19.2 98.6 0.0012 17.2 1.7 5.2 1 1 2 3 3 3 2 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF3439 PF11921.3 EWC44209.1 - 0.0089 15.7 8.4 0.02 14.6 5.9 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3439) SSP160 PF06933.6 EWC44209.1 - 0.22 9.4 7.5 0.48 8.3 5.2 1.5 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Herpes_BLLF1 PF05109.8 EWC44209.1 - 8.6 4.1 22.8 12 3.7 15.8 1.1 1 0 0 1 1 1 0 Herpes virus major outer envelope glycoprotein (BLLF1) Med17 PF10156.4 EWC44210.1 - 1.3e-69 234.7 0.3 1.9e-69 234.1 0.1 1.2 1 1 0 1 1 1 1 Subunit 17 of Mediator complex DASH_Hsk3 PF08227.6 EWC44210.1 - 8.6e-17 61.0 5.4 1.6e-16 60.1 3.7 1.5 1 0 0 1 1 1 1 DASH complex subunit Hsk3 like Inhibitor_I71 PF12628.2 EWC44210.1 - 0.014 15.0 0.4 0.024 14.3 0.2 1.3 1 0 0 1 1 1 0 Falstatin, cysteine peptidase inhibitor TRAP_alpha PF03896.11 EWC44210.1 - 0.28 10.1 2.9 0.45 9.4 2.0 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DSHCT PF08148.7 EWC44211.1 - 1.3e-62 210.1 0.1 9.4e-62 207.4 0.1 2.2 2 0 0 2 2 2 1 DSHCT (NUC185) domain DEAD PF00270.24 EWC44211.1 - 1.1e-20 73.8 0.0 2.1e-20 72.8 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EWC44211.1 - 2.7e-07 30.3 0.0 7.2e-07 28.9 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain rRNA_proc-arch PF13234.1 EWC44211.1 - 1.8e-05 24.0 1.1 8.8e-05 21.7 0.8 2.0 1 1 0 1 1 1 1 rRNA-processing arch domain ResIII PF04851.10 EWC44211.1 - 0.017 14.9 0.0 0.28 10.9 0.0 2.5 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit IBN_N PF03810.14 EWC44212.1 - 2e-17 62.8 1.0 2.6e-16 59.3 0.1 2.8 2 0 0 2 2 2 1 Importin-beta N-terminal domain Cse1 PF08506.5 EWC44212.1 - 3.5e-11 42.3 0.4 8.2e-11 41.0 0.3 1.6 1 0 0 1 1 1 1 Cse1 HEAT_2 PF13646.1 EWC44212.1 - 6.6e-05 23.1 0.7 1.3 9.3 0.1 4.8 4 1 0 4 4 4 1 HEAT repeats Cnd1 PF12717.2 EWC44212.1 - 0.00048 20.0 0.4 0.0051 16.6 0.1 3.0 2 1 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.1 EWC44212.1 - 0.0017 18.8 0.1 13 6.4 0.0 5.0 5 0 0 5 5 5 1 HEAT-like repeat Xpo1 PF08389.7 EWC44212.1 - 0.0017 18.2 4.2 0.037 13.9 0.0 4.1 3 0 0 3 3 3 1 Exportin 1-like protein DUF2435 PF10363.4 EWC44212.1 - 0.0021 17.8 0.3 0.01 15.6 0.2 2.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2435) Alpha_E3_glycop PF01563.11 EWC44212.1 - 0.055 13.2 0.0 3.1 7.6 0.0 3.2 3 0 0 3 3 3 0 Alphavirus E3 glycoprotein Pox_M2 PF04887.7 EWC44212.1 - 0.066 12.5 0.0 0.15 11.3 0.0 1.5 1 0 0 1 1 1 0 Poxvirus M2 protein CBFD_NFYB_HMF PF00808.18 EWC44213.1 - 4.5e-20 71.4 1.3 4.5e-20 71.4 0.9 1.9 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 EWC44213.1 - 0.00059 19.9 0.2 0.0016 18.5 0.0 1.7 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 PrkA PF06798.7 EWC44213.1 - 0.0016 17.7 0.5 0.0018 17.5 0.3 1.1 1 0 0 1 1 1 1 PrkA serine protein kinase C-terminal domain Decorin_bind PF02352.10 EWC44213.1 - 0.022 14.7 1.1 0.042 13.8 0.7 1.5 1 1 0 1 1 1 0 Decorin binding protein Bromo_TP PF07524.8 EWC44213.1 - 0.038 13.7 0.1 0.075 12.7 0.0 1.5 1 1 0 1 1 1 0 Bromodomain associated MRP-S27 PF10037.4 EWC44213.1 - 1.2 7.9 5.4 2.4 6.9 3.7 1.5 1 1 0 1 1 1 0 Mitochondrial 28S ribosomal protein S27 Actin PF00022.14 EWC44214.1 - 6.6e-94 314.5 0.0 7.9e-94 314.2 0.0 1.0 1 0 0 1 1 1 1 Actin PilM_2 PF11104.3 EWC44214.1 - 0.11 11.3 0.0 13 4.5 0.0 2.1 2 0 0 2 2 2 0 Type IV pilus assembly protein PilM; Pribosyltran PF00156.22 EWC44215.1 - 3e-10 39.9 0.2 2.3e-09 37.0 0.1 2.0 1 1 0 1 1 1 1 Phosphoribosyl transferase domain DUF383 PF04063.9 EWC44216.1 - 3.3e-63 212.7 0.1 1.1e-62 210.9 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF383) DUF384 PF04064.8 EWC44216.1 - 1.2e-19 69.6 1.0 1.2e-19 69.6 0.7 2.7 3 0 0 3 3 3 1 Domain of unknown function (DUF384) ATP-grasp_2 PF08442.5 EWC44217.1 - 7.7e-77 257.2 0.4 1.4e-76 256.3 0.3 1.4 1 0 0 1 1 1 1 ATP-grasp domain Ligase_CoA PF00549.14 EWC44217.1 - 1.1e-26 93.3 0.2 2.2e-26 92.2 0.1 1.6 1 0 0 1 1 1 1 CoA-ligase ATP-grasp_5 PF13549.1 EWC44217.1 - 4.4e-09 35.8 0.4 1.1e-08 34.5 0.1 1.8 2 0 0 2 2 2 1 ATP-grasp domain GARS_A PF01071.14 EWC44217.1 - 0.00032 20.3 1.1 0.0026 17.3 0.1 2.5 2 1 0 2 2 2 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Succ_CoA_lig PF13607.1 EWC44217.1 - 0.012 15.1 0.1 1.5 8.3 0.0 2.6 1 1 1 2 2 2 0 Succinyl-CoA ligase like flavodoxin domain Peripla_BP_2 PF01497.13 EWC44217.1 - 0.045 12.8 0.2 0.088 11.9 0.1 1.4 1 0 0 1 1 1 0 Periplasmic binding protein DUF3245 PF11595.3 EWC44218.1 - 1.4e-14 54.6 3.8 3.3e-14 53.4 2.7 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3245) HSF_DNA-bind PF00447.12 EWC44219.1 - 1.6e-36 124.6 0.2 2.8e-36 123.8 0.1 1.4 1 0 0 1 1 1 1 HSF-type DNA-binding F-box PF00646.28 EWC44220.1 - 3.8e-10 39.1 0.4 1.1e-09 37.6 0.2 1.9 1 1 1 2 2 2 1 F-box domain F-box-like PF12937.2 EWC44220.1 - 1.1e-07 31.4 0.6 1.8e-07 30.7 0.4 1.4 1 0 0 1 1 1 1 F-box-like DnaB_bind PF10410.4 EWC44220.1 - 0.05 13.6 0.0 2.4 8.2 0.0 2.6 2 0 0 2 2 2 0 DnaB-helicase binding domain of primase SMC_Nse1 PF07574.8 EWC44221.1 - 1.7e-29 102.9 0.0 2.3e-29 102.4 0.0 1.2 1 0 0 1 1 1 1 Nse1 non-SMC component of SMC5-6 complex zf-RING-like PF08746.6 EWC44221.1 - 1.2e-09 37.9 11.4 2.4e-09 37.0 7.9 1.5 1 0 0 1 1 1 1 RING-like domain zf-HC5HC2H_2 PF13832.1 EWC44221.1 - 7.6e-05 22.6 2.4 0.00015 21.6 1.7 1.4 1 0 0 1 1 1 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.1 EWC44221.1 - 0.00036 20.6 2.4 0.00076 19.5 1.7 1.5 1 0 0 1 1 1 1 PHD-like zinc-binding domain Mcm10 PF09332.6 EWC44221.1 - 0.16 11.2 4.9 0.3 10.3 3.4 1.5 1 1 0 1 1 1 0 Mcm10 replication factor zf-RING_2 PF13639.1 EWC44221.1 - 2.3 8.1 10.3 4.5 7.1 7.1 1.5 1 0 0 1 1 1 0 Ring finger domain zf-RING_4 PF14570.1 EWC44221.1 - 4.8 6.8 7.4 9.5 5.8 5.1 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Bystin PF05291.6 EWC44222.1 - 6.3e-133 442.3 0.0 8.5e-133 441.9 0.0 1.1 1 0 0 1 1 1 1 Bystin Mak16 PF04874.9 EWC44222.1 - 2.8 8.0 11.6 0.37 10.8 0.1 2.7 2 0 0 2 2 2 0 Mak16 protein C-terminal region Sec63 PF02889.11 EWC44224.1 - 1.1e-148 494.6 0.0 1.5e-92 310.1 0.1 2.2 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.24 EWC44224.1 - 1e-52 178.0 0.0 1.7e-28 99.2 0.2 4.0 5 0 0 5 5 5 2 DEAD/DEAH box helicase ResIII PF04851.10 EWC44224.1 - 1.4e-17 64.1 0.0 3.9e-08 33.3 0.0 2.6 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.26 EWC44224.1 - 1.9e-15 56.4 0.0 1.6e-06 27.8 0.0 2.7 2 0 0 2 2 2 2 Helicase conserved C-terminal domain AAA_22 PF13401.1 EWC44224.1 - 2.8e-07 30.7 0.2 0.034 14.3 0.0 3.5 3 2 0 3 3 2 2 AAA domain SNF2_N PF00176.18 EWC44224.1 - 8.8e-07 28.0 0.3 0.0076 15.0 0.1 2.3 2 0 0 2 2 2 2 SNF2 family N-terminal domain AAA_19 PF13245.1 EWC44224.1 - 3.2e-05 23.5 0.0 0.042 13.6 0.0 2.9 2 0 0 2 2 2 2 Part of AAA domain AAA PF00004.24 EWC44224.1 - 0.00079 19.6 0.4 0.48 10.6 0.0 4.0 4 0 0 4 4 4 1 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.12 EWC44224.1 - 0.0026 17.1 0.1 8.1 5.8 0.0 3.8 4 0 0 4 4 4 2 IstB-like ATP binding protein T2SE PF00437.15 EWC44224.1 - 0.0039 16.1 0.0 0.17 10.7 0.0 2.4 2 0 0 2 2 2 1 Type II/IV secretion system protein Alba PF01918.16 EWC44224.1 - 0.13 11.8 0.0 1.2 8.7 0.0 2.5 2 0 0 2 2 2 0 Alba PAP_assoc PF03828.14 EWC44225.1 - 2e-17 62.8 0.4 9.6e-17 60.6 0.0 2.2 2 0 0 2 2 2 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.18 EWC44225.1 - 0.00051 20.3 0.0 0.0013 18.9 0.0 1.7 1 0 0 1 1 1 1 Nucleotidyltransferase domain PAP_central PF04928.12 EWC44225.1 - 0.026 13.3 0.0 1.6 7.4 0.0 2.4 2 0 0 2 2 2 0 Poly(A) polymerase central domain Bud13 PF09736.4 EWC44226.1 - 2.1e-42 144.8 2.5 2.1e-42 144.8 1.7 1.4 2 0 0 2 2 2 1 Pre-mRNA-splicing factor of RES complex Thymidylate_kin PF02223.12 EWC44226.1 - 0.051 12.9 1.6 0.072 12.4 1.1 1.4 1 0 0 1 1 1 0 Thymidylate kinase DUF2335 PF10097.4 EWC44226.1 - 1.4 8.6 4.9 4.5 6.9 3.2 2.0 1 1 0 1 1 1 0 Predicted membrane protein (DUF2335) Myosin_HC-like PF07058.6 EWC44227.1 - 0.037 13.1 0.4 0.075 12.1 0.3 1.5 1 0 0 1 1 1 0 Myosin II heavy chain-like DUF3481 PF11980.3 EWC44229.1 - 0.096 12.5 0.1 0.24 11.2 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3481) Pro_CA PF00484.14 EWC44230.1 - 1.3e-47 161.5 0.2 1.7e-47 161.2 0.1 1.1 1 0 0 1 1 1 1 Carbonic anhydrase BCS1_N PF08740.6 EWC44231.1 - 1.9e-31 109.1 5.3 3.6e-31 108.2 3.6 1.4 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.24 EWC44231.1 - 2.1e-19 70.0 0.0 4.8e-19 68.8 0.0 1.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 EWC44231.1 - 1.1e-05 26.2 0.2 4.7e-05 24.1 0.1 2.2 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.1 EWC44231.1 - 0.00072 19.0 0.0 0.002 17.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 EWC44231.1 - 0.0085 16.0 0.1 0.073 13.0 0.0 2.3 3 0 0 3 3 3 1 AAA ATPase domain DUF815 PF05673.8 EWC44231.1 - 0.013 14.3 0.0 1.3 7.8 0.0 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF815) IstB_IS21 PF01695.12 EWC44231.1 - 0.054 12.9 0.1 0.12 11.8 0.1 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_29 PF13555.1 EWC44231.1 - 0.13 11.7 0.0 0.9 9.1 0.0 2.3 2 0 0 2 2 2 0 P-loop containing region of AAA domain KaiC PF06745.8 EWC44231.1 - 0.14 11.2 0.0 0.26 10.3 0.0 1.3 1 0 0 1 1 1 0 KaiC DHC PF09626.5 EWC44231.1 - 0.15 12.7 0.7 0.35 11.5 0.5 1.6 1 0 0 1 1 1 0 Dihaem cytochrome c Sld5 PF05916.6 EWC44232.1 - 2.6e-06 27.6 0.0 3e-06 27.4 0.0 1.1 1 0 0 1 1 1 1 GINS complex protein Sod_Fe_C PF02777.13 EWC44233.1 - 1.1e-40 137.6 0.3 2e-40 136.9 0.2 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.17 EWC44233.1 - 7.9e-31 106.1 0.9 1.3e-30 105.4 0.6 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain DnaJ PF00226.26 EWC44235.1 - 4.6e-28 96.7 2.6 7.8e-28 96.0 1.8 1.4 1 0 0 1 1 1 1 DnaJ domain CTDII PF01556.13 EWC44235.1 - 2.4e-22 78.5 2.0 1e-21 76.5 0.4 2.3 2 0 0 2 2 2 1 DnaJ C terminal domain Enkurin PF13864.1 EWC44235.1 - 0.1 12.8 1.1 0.17 12.1 0.8 1.3 1 0 0 1 1 1 0 Calmodulin-binding Med3 PF11593.3 EWC44239.1 - 6.2 5.9 11.6 10 5.2 8.0 1.4 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Abhydrolase_5 PF12695.2 EWC44240.1 - 5.5e-06 26.1 0.0 9e-06 25.5 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF676 PF05057.9 EWC44240.1 - 1.9e-05 24.0 0.0 3.2e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_6 PF12697.2 EWC44240.1 - 2e-05 24.6 0.2 3.6e-05 23.7 0.1 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.8 EWC44240.1 - 3e-05 23.7 0.0 8.3e-05 22.2 0.0 1.7 1 1 0 1 1 1 1 PGAP1-like protein Lipase_3 PF01764.20 EWC44240.1 - 0.036 13.6 0.0 0.061 12.9 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) DUF2974 PF11187.3 EWC44240.1 - 0.15 11.4 0.0 0.25 10.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Amidohydro_2 PF04909.9 EWC44243.1 - 1.2e-12 48.0 0.0 1.8e-12 47.3 0.0 1.6 1 1 0 1 1 1 1 Amidohydrolase BON PF04972.12 EWC44243.1 - 0.085 12.6 0.1 4.7 7.0 0.0 2.4 2 0 0 2 2 2 0 BON domain MMR_HSR1_C PF08438.5 EWC44244.1 - 7.4e-29 100.1 0.0 1.2e-28 99.4 0.0 1.3 1 0 0 1 1 1 1 GTPase of unknown function C-terminal MMR_HSR1 PF01926.18 EWC44244.1 - 1.2e-18 67.2 0.0 3.5e-18 65.6 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.13 EWC44244.1 - 1.2e-10 40.9 0.0 5e-08 32.3 0.0 2.4 2 0 0 2 2 2 2 Ferrous iron transport protein B Dynamin_N PF00350.18 EWC44244.1 - 0.0056 16.5 1.1 0.03 14.1 0.2 2.4 3 0 0 3 3 3 1 Dynamin family GTP_EFTU PF00009.22 EWC44244.1 - 0.081 12.3 0.2 1.8 7.9 0.0 2.4 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain AIG1 PF04548.11 EWC44244.1 - 0.088 11.9 0.0 0.16 11.0 0.0 1.3 1 0 0 1 1 1 0 AIG1 family AAA_21 PF13304.1 EWC44244.1 - 0.092 12.6 0.3 6.3 6.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.1 EWC44244.1 - 0.11 12.7 0.0 10 6.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain ATP_bind_1 PF03029.12 EWC44244.1 - 0.12 11.9 0.1 3.8 6.9 0.0 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein KTI12 PF08433.5 EWC44244.1 - 0.12 11.5 0.0 0.22 10.6 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 Zeta_toxin PF06414.7 EWC44244.1 - 0.14 11.1 0.0 0.94 8.5 0.0 2.0 2 0 0 2 2 2 0 Zeta toxin MFS_1 PF07690.11 EWC44245.1 - 3.4e-06 26.0 33.8 0.00016 20.5 18.2 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2837 PF10997.3 EWC44245.1 - 0.016 14.3 1.7 1.8 7.6 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2837) DUF962 PF06127.6 EWC44245.1 - 1.6 8.7 5.3 0.33 10.8 0.1 2.5 3 1 0 3 3 3 0 Protein of unknown function (DUF962) ECH PF00378.15 EWC44246.1 - 7.9e-47 159.4 0.0 1.1e-46 158.9 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family Peptidase_S49 PF01343.13 EWC44246.1 - 8.6e-05 22.3 0.0 0.32 10.7 0.0 2.3 2 0 0 2 2 2 2 Peptidase family S49 DUF3074 PF11274.3 EWC44249.1 - 4.2e-30 104.7 0.0 5.4e-30 104.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3074) Lactonase PF10282.4 EWC44250.1 - 1.1e-75 254.8 0.0 1.4e-75 254.4 0.0 1.1 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller Pox_I3 PF04661.7 EWC44250.1 - 0.0067 15.2 0.0 0.0098 14.7 0.0 1.1 1 0 0 1 1 1 1 Poxvirus I3 ssDNA-binding protein YmzC PF14157.1 EWC44250.1 - 0.058 13.2 0.0 12 5.8 0.0 2.7 2 0 0 2 2 2 0 YmzC-like protein PNGaseA PF12222.3 EWC44252.1 - 2.2e-92 310.1 2.3 2.9e-92 309.7 1.6 1.1 1 0 0 1 1 1 1 Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A Cellulase PF00150.13 EWC44253.1 - 7.8e-45 153.2 2.5 1.2e-44 152.6 1.7 1.2 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) DUF2721 PF11026.3 EWC44254.1 - 0.12 12.0 3.4 0.23 11.0 2.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) IncA PF04156.9 EWC44254.1 - 1.1 8.8 4.4 2.3 7.7 3.1 1.5 1 0 0 1 1 1 0 IncA protein Methyltransf_23 PF13489.1 EWC44255.1 - 4.2e-19 68.8 0.0 5.7e-19 68.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EWC44255.1 - 5.1e-10 39.7 0.0 9.1e-10 38.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EWC44255.1 - 3.4e-09 37.2 0.0 7.6e-08 32.9 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EWC44255.1 - 9.5e-08 31.7 0.0 0.0096 15.5 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.7 EWC44255.1 - 3.6e-07 30.5 0.0 4.1e-06 27.1 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EWC44255.1 - 0.0001 22.6 0.0 0.00034 20.9 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EWC44255.1 - 0.00011 21.4 0.0 0.0027 16.8 0.0 2.2 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_26 PF13659.1 EWC44255.1 - 0.0011 19.0 0.0 0.012 15.5 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 EWC44255.1 - 0.0024 16.9 0.0 0.013 14.5 0.0 2.0 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_16 PF10294.4 EWC44255.1 - 0.0077 15.7 0.0 0.012 15.0 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase FtsJ PF01728.14 EWC44255.1 - 0.0077 16.2 0.0 0.013 15.5 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase PrmA PF06325.8 EWC44255.1 - 0.011 14.8 0.0 0.019 14.1 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.9 EWC44255.1 - 0.042 13.2 0.0 0.13 11.6 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_2 PF00891.13 EWC44255.1 - 0.046 12.8 0.0 0.076 12.1 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase DUF938 PF06080.7 EWC44255.1 - 0.091 12.2 0.0 0.15 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Methyltransf_2 PF00891.13 EWC44256.1 - 1.5e-35 122.5 0.0 2.2e-35 121.9 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_18 PF12847.2 EWC44256.1 - 5.3e-06 26.9 0.0 1.9e-05 25.2 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.9 EWC44256.1 - 0.0054 16.1 0.0 0.0088 15.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.1 EWC44256.1 - 0.028 14.0 0.0 0.045 13.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain AcetylCoA_hyd_C PF13336.1 EWC44257.1 - 0.093 12.3 0.7 0.1 12.2 0.5 1.1 1 0 0 1 1 1 0 Acetyl-CoA hydrolase/transferase C-terminal domain Pheromone PF08015.6 EWC44257.1 - 0.67 10.8 5.6 1.3 9.9 3.9 1.6 1 0 0 1 1 1 0 Fungal mating-type pheromone DUF1720 PF08226.6 EWC44257.1 - 9.6 6.3 14.7 15 5.7 10.2 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF1720) Fungal_trans_2 PF11951.3 EWC44258.1 - 2.5e-08 32.9 0.1 3.5e-08 32.4 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EWC44258.1 - 1.7e-07 31.0 7.5 2.9e-07 30.2 5.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Cellulase PF00150.13 EWC44259.1 - 5.2e-11 42.2 0.0 7.3e-11 41.7 0.0 1.2 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) HpcH_HpaI PF03328.9 EWC44260.1 - 8.3e-35 119.6 0.0 3e-18 65.5 0.0 2.1 1 1 1 2 2 2 2 HpcH/HpaI aldolase/citrate lyase family C-C_Bond_Lyase PF15617.1 EWC44260.1 - 4.6e-14 52.0 0.0 7.3e-06 25.0 0.0 2.9 2 1 0 3 3 3 2 C-C_Bond_Lyase of the TIM-Barrel fold PEPcase PF00311.12 EWC44260.1 - 0.058 11.2 0.0 0.084 10.7 0.0 1.1 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxylase Glyco_hydro_18 PF00704.23 EWC44261.1 - 1.6e-10 41.0 0.0 3.2e-10 39.9 0.0 1.5 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 p450 PF00067.17 EWC44262.1 - 1.5e-47 162.1 0.0 2e-47 161.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 RTA1 PF04479.8 EWC44263.1 - 8.3e-50 169.3 7.0 1.1e-49 168.9 4.9 1.1 1 0 0 1 1 1 1 RTA1 like protein Bap31 PF05529.7 EWC44263.1 - 3.1 7.2 4.3 0.36 10.2 0.1 1.5 2 0 0 2 2 2 0 B-cell receptor-associated protein 31-like Catalase PF00199.14 EWC44264.1 - 6.3e-62 209.4 0.0 7.8e-62 209.1 0.0 1.0 1 0 0 1 1 1 1 Catalase UPF0182 PF03699.8 EWC44265.1 - 0.49 8.2 5.6 0.69 7.7 3.9 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0182) Ceramidase_alk PF04734.8 EWC44267.1 - 3.8e-272 904.1 0.0 4.5e-272 903.9 0.0 1.0 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase A2M_N PF01835.14 EWC44267.1 - 0.056 13.7 0.0 0.4 10.9 0.0 2.4 2 1 0 2 2 2 0 MG2 domain GST_C_2 PF13410.1 EWC44269.1 - 2e-11 43.5 0.1 7.6e-11 41.7 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 EWC44269.1 - 2e-07 30.9 0.0 5.3e-07 29.5 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 EWC44269.1 - 2.4e-06 27.9 0.0 5.2e-06 26.8 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.1 EWC44269.1 - 5.5e-05 23.3 0.0 0.00012 22.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain CMD PF02627.15 EWC44270.1 - 0.19 11.6 1.4 0.75 9.6 0.0 2.2 2 0 0 2 2 2 0 Carboxymuconolactone decarboxylase family Pkinase PF00069.20 EWC44271.1 - 4e-09 36.0 0.0 5.4e-09 35.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC44271.1 - 0.0023 17.0 0.0 0.0038 16.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase CTP_transf_2 PF01467.21 EWC44272.1 - 8.9e-13 48.5 0.0 3.8e-11 43.2 0.0 2.6 2 0 0 2 2 2 1 Cytidylyltransferase IBR PF01485.16 EWC44272.1 - 1.4e-12 47.3 43.6 2.7e-06 27.1 9.5 3.8 3 0 0 3 3 3 3 IBR domain Polysacc_deac_1 PF01522.16 EWC44274.1 - 6.7e-28 96.8 0.0 1.7e-27 95.5 0.0 1.6 2 0 0 2 2 2 1 Polysaccharide deacetylase Chitin_bind_1 PF00187.14 EWC44274.1 - 0.026 14.5 3.4 0.026 14.5 2.3 1.9 2 0 0 2 2 2 0 Chitin recognition protein DAGK_cat PF00781.19 EWC44275.1 - 8e-10 38.2 0.0 1.3e-09 37.5 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain D-ser_dehydrat PF14031.1 EWC44276.1 - 2.8e-23 81.9 0.2 6.4e-23 80.7 0.0 1.7 2 0 0 2 2 2 1 Putative serine dehydratase domain Ala_racemase_N PF01168.15 EWC44276.1 - 2.1e-16 60.1 0.0 3e-16 59.6 0.0 1.2 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain Amidohydro_2 PF04909.9 EWC44276.1 - 0.045 13.3 0.3 0.19 11.2 0.0 1.9 2 0 0 2 2 2 0 Amidohydrolase AAA_17 PF13207.1 EWC44277.1 - 5e-05 24.1 0.1 0.00015 22.5 0.1 2.0 1 1 0 1 1 1 1 AAA domain ArgK PF03308.11 EWC44277.1 - 0.0002 20.2 0.0 0.00031 19.6 0.0 1.2 1 0 0 1 1 1 1 ArgK protein KAP_NTPase PF07693.9 EWC44277.1 - 0.00066 18.7 0.0 0.00066 18.7 0.0 1.1 1 0 0 1 1 1 1 KAP family P-loop domain PRK PF00485.13 EWC44277.1 - 0.0015 18.1 0.0 0.0024 17.4 0.0 1.3 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_16 PF13191.1 EWC44277.1 - 0.0037 17.2 0.0 0.0068 16.4 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.1 EWC44277.1 - 0.0042 16.5 0.0 0.021 14.2 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.1 EWC44277.1 - 0.0044 17.3 0.0 0.012 15.9 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.1 EWC44277.1 - 0.0069 15.8 0.2 0.041 13.4 0.0 2.3 3 0 0 3 3 3 1 P-loop containing region of AAA domain SRP54 PF00448.17 EWC44277.1 - 0.0096 15.3 0.0 0.012 15.0 0.0 1.2 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain Zeta_toxin PF06414.7 EWC44277.1 - 0.011 14.8 0.0 0.016 14.3 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_33 PF13671.1 EWC44277.1 - 0.014 15.3 0.2 0.032 14.1 0.1 1.5 1 1 0 1 1 1 0 AAA domain Torsin PF06309.6 EWC44277.1 - 0.024 14.5 0.0 0.058 13.2 0.0 1.7 1 0 0 1 1 1 0 Torsin NACHT PF05729.7 EWC44277.1 - 0.025 14.2 0.0 0.036 13.7 0.0 1.3 1 0 0 1 1 1 0 NACHT domain Virul_Fac PF10139.4 EWC44277.1 - 0.036 12.0 0.0 0.048 11.5 0.0 1.1 1 0 0 1 1 1 0 Putative bacterial virulence factor FtsK_SpoIIIE PF01580.13 EWC44277.1 - 0.038 13.4 0.0 0.13 11.7 0.0 1.8 1 1 0 1 1 1 0 FtsK/SpoIIIE family SMC_N PF02463.14 EWC44277.1 - 0.055 12.7 0.0 0.087 12.0 0.0 1.2 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_19 PF13245.1 EWC44277.1 - 0.057 13.1 0.0 0.17 11.6 0.0 1.8 2 0 0 2 2 1 0 Part of AAA domain MobB PF03205.9 EWC44277.1 - 0.061 13.0 0.0 0.21 11.3 0.0 1.8 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B APS_kinase PF01583.15 EWC44277.1 - 0.068 12.8 0.0 0.1 12.2 0.0 1.2 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_30 PF13604.1 EWC44277.1 - 0.077 12.5 0.0 0.13 11.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain CbiA PF01656.18 EWC44277.1 - 0.099 12.0 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain KTI12 PF08433.5 EWC44277.1 - 0.11 11.6 0.0 0.15 11.1 0.0 1.2 1 0 0 1 1 1 0 Chromatin associated protein KTI12 UPF0079 PF02367.12 EWC44277.1 - 0.12 12.0 0.0 0.21 11.2 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 AAA_5 PF07728.9 EWC44277.1 - 0.13 11.9 0.0 0.39 10.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Glyco_transf_92 PF01697.22 EWC44278.1 - 5.1e-14 52.2 0.6 8e-14 51.6 0.4 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 92 Glyco_tranf_2_4 PF13704.1 EWC44278.1 - 1.1e-08 35.2 0.4 1.9e-08 34.5 0.3 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Virul_fac_BrkB PF03631.10 EWC44278.1 - 0.062 12.6 0.1 1.7 7.9 0.0 2.0 2 0 0 2 2 2 0 Virulence factor BrkB Glyco_hydro_10 PF00331.15 EWC44280.1 - 8.6e-85 284.5 0.1 1e-84 284.2 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 DUF4339 PF14237.1 EWC44280.1 - 0.041 13.4 0.0 0.085 12.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4339) TcpQ PF10671.4 EWC44280.1 - 0.093 12.6 1.1 0.32 10.9 0.1 2.2 2 1 0 2 2 2 0 Toxin co-regulated pilus biosynthesis protein Q Glyco_hydro_1 PF00232.13 EWC44280.1 - 0.13 10.4 1.6 0.22 9.6 0.2 1.9 2 0 0 2 2 2 0 Glycosyl hydrolase family 1 C2 PF00168.25 EWC44284.1 - 1.5e-10 40.7 0.0 3.3e-10 39.6 0.0 1.6 1 0 0 1 1 1 1 C2 domain PEP_mutase PF13714.1 EWC44285.1 - 1.1e-59 201.5 0.6 1.2e-59 201.3 0.4 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase Ferric_reduct PF01794.14 EWC44287.1 - 1.5e-13 50.9 7.9 3.5e-13 49.7 5.5 1.6 1 0 0 1 1 1 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.7 EWC44287.1 - 2.6e-13 50.1 0.0 9.8e-06 25.5 0.0 2.2 1 1 1 2 2 2 2 Ferric reductase NAD binding domain FAD_binding_8 PF08022.7 EWC44287.1 - 6.2e-11 42.1 0.0 1.3e-10 41.1 0.0 1.5 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_1 PF00175.16 EWC44287.1 - 1.5e-07 31.9 0.0 2.9e-07 31.0 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain DUF2871 PF11070.3 EWC44287.1 - 2 8.5 5.6 12 6.0 2.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2871) DcpS_C PF11969.3 EWC44289.1 - 1.9e-16 60.3 0.7 8.1e-07 29.2 0.0 2.3 2 0 0 2 2 2 2 Scavenger mRNA decapping enzyme C-term binding HIT PF01230.18 EWC44289.1 - 1.6e-12 47.8 0.4 5.8e-12 46.0 0.3 1.9 1 1 0 1 1 1 1 HIT domain zf-C2H2_2 PF12756.2 EWC44289.1 - 0.094 12.8 0.1 0.21 11.7 0.0 1.5 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) mIF3 PF14877.1 EWC44290.1 - 0.067 12.5 0.1 0.11 11.8 0.1 1.3 1 0 0 1 1 1 0 Mitochondrial translation initiation factor HSP70 PF00012.15 EWC44291.1 - 4e-10 38.2 0.0 5.4e-10 37.8 0.0 1.1 1 0 0 1 1 1 1 Hsp70 protein RHS_repeat PF05593.9 EWC44292.1 - 0.00062 19.8 20.5 0.023 14.8 0.3 6.6 7 1 1 8 8 8 3 RHS Repeat SpvB PF03534.8 EWC44293.1 - 1.1e-76 257.7 0.0 1.6e-76 257.1 0.0 1.3 1 0 0 1 1 1 1 Salmonella virulence plasmid 65kDa B protein TcdB_toxin_midN PF12256.3 EWC44293.1 - 1.3e-40 138.6 7.7 9.1e-29 100.1 0.0 6.8 2 1 4 7 7 7 5 Insecticide toxin TcdB middle/N-terminal region TcdB_toxin_midC PF12255.3 EWC44293.1 - 1.6e-26 92.7 0.2 4e-26 91.4 0.1 1.7 1 0 0 1 1 1 1 Insecticide toxin TcdB middle/C-terminal region VCBS PF13517.1 EWC44293.1 - 4.8e-13 49.2 10.4 9.1e-07 29.1 2.1 4.6 3 1 1 4 4 4 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 EWC44293.1 - 0.0014 18.2 18.7 1.2 8.9 0.1 5.2 5 0 0 5 5 5 3 FG-GAP repeat WEMBL PF05701.6 EWC44294.1 - 0.0098 14.4 0.9 0.0098 14.4 0.6 2.6 3 0 0 3 3 3 2 Weak chloroplast movement under blue light Calici_MSP PF05752.6 EWC44294.1 - 0.051 13.1 0.1 0.1 12.1 0.0 1.4 1 0 0 1 1 1 0 Calicivirus minor structural protein Rab5-bind PF09311.6 EWC44294.1 - 1.6 8.5 7.2 0.1 12.4 0.4 2.3 3 0 0 3 3 3 0 Rabaptin-like protein VirionAssem_T7 PF11653.3 EWC44295.1 - 0.67 10.7 13.0 2.6 8.8 3.4 2.8 2 1 0 2 2 2 0 Bacteriophage T7 virion assembly protein DUF2786 PF10979.3 EWC44295.1 - 0.9 9.3 5.3 4.9 6.9 0.6 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2786) ATP_transf PF09830.4 EWC44296.1 - 1e-09 38.0 0.0 1.7e-09 37.3 0.0 1.4 1 0 0 1 1 1 1 ATP adenylyltransferase Ion_trans_2 PF07885.11 EWC44297.1 - 5.3e-28 96.5 26.1 1.2e-17 63.3 3.3 3.7 3 1 0 3 3 3 2 Ion channel Lig_chan PF00060.21 EWC44297.1 - 0.0099 15.6 4.2 0.0099 15.6 2.9 2.5 2 1 0 3 3 3 1 Ligand-gated ion channel Ion_trans PF00520.26 EWC44297.1 - 1.9 7.6 15.2 0.064 12.4 4.6 2.4 2 0 0 2 2 2 0 Ion transport protein MFS_1 PF07690.11 EWC44298.1 - 7.5e-20 70.9 36.7 7.5e-20 70.9 25.5 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Nucleotid_trans PF03407.11 EWC44299.1 - 1.8e-15 57.3 0.4 1.8e-15 57.3 0.2 1.7 2 0 0 2 2 2 1 Nucleotide-diphospho-sugar transferase FAD_binding_4 PF01565.18 EWC44300.1 - 2.5e-21 75.5 1.4 3.1e-21 75.3 0.1 1.8 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.7 EWC44300.1 - 5.6e-06 26.1 0.4 1.7e-05 24.6 0.3 1.7 1 0 0 1 1 1 1 Berberine and berberine like Peptidase_S8 PF00082.17 EWC44301.1 - 0.0013 17.9 0.0 0.0017 17.5 0.0 1.2 1 0 0 1 1 1 1 Subtilase family Trypan_PARP PF05887.6 EWC44302.1 - 0.072 12.9 6.3 0.15 11.9 4.4 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) DUF4614 PF15391.1 EWC44302.1 - 0.75 9.5 32.6 1.7 8.3 22.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) PPP4R2 PF09184.6 EWC44302.1 - 4.1 6.8 16.5 7.2 6.0 11.4 1.3 1 0 0 1 1 1 0 PPP4R2 Hid1 PF12722.2 EWC44302.1 - 4.3 4.8 16.6 6 4.4 11.5 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SprA-related PF12118.3 EWC44302.1 - 6.9 5.9 26.3 12 5.1 18.2 1.2 1 0 0 1 1 1 0 SprA-related family MARVEL PF01284.18 EWC44305.1 - 0.00026 20.8 11.2 0.00026 20.8 7.7 1.8 1 1 1 2 2 2 1 Membrane-associating domain Tetraspannin PF00335.15 EWC44305.1 - 0.65 9.2 14.3 0.19 10.9 6.4 1.9 1 1 0 2 2 2 0 Tetraspanin family DUF2975 PF11188.3 EWC44305.1 - 0.86 9.3 8.3 14 5.4 3.5 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF2975) DUF373 PF04123.8 EWC44305.1 - 0.89 8.5 4.0 0.73 8.7 1.1 1.8 1 1 0 2 2 2 0 Domain of unknown function (DUF373) DUF4336 PF14234.1 EWC44306.1 - 1e-16 60.9 0.0 3e-12 46.3 0.0 2.6 2 1 0 2 2 2 2 Domain of unknown function (DUF4336) AA_permease PF00324.16 EWC44307.1 - 1e-132 442.9 39.5 1.2e-132 442.6 27.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EWC44307.1 - 7.3e-41 140.0 43.3 9e-41 139.7 30.0 1.1 1 0 0 1 1 1 1 Amino acid permease Adeno_E3_CR2 PF02439.10 EWC44307.1 - 0.48 10.0 4.1 1.6 8.3 2.8 1.9 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Asp PF00026.18 EWC44308.1 - 1.1e-32 113.5 0.5 1.3e-32 113.2 0.3 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease SKG6 PF08693.5 EWC44308.1 - 0.0064 15.7 0.3 0.014 14.6 0.2 1.6 1 0 0 1 1 1 1 Transmembrane alpha-helix domain GRP PF07172.6 EWC44308.1 - 0.058 13.8 7.8 0.13 12.7 5.4 1.5 1 0 0 1 1 1 0 Glycine rich protein family FSH1 PF03959.8 EWC44310.1 - 3.3e-61 206.4 0.0 3.7e-61 206.2 0.0 1.0 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_5 PF12695.2 EWC44310.1 - 7.5e-09 35.4 0.0 1.1e-08 34.9 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 EWC44310.1 - 3.6e-06 27.0 4.0 0.0024 17.7 0.1 2.2 1 1 1 2 2 2 2 Alpha/beta hydrolase family Abhydrolase_2 PF02230.11 EWC44310.1 - 0.031 13.7 0.0 4.1 6.7 0.0 2.3 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase BAAT_C PF08840.6 EWC44310.1 - 0.037 13.7 0.0 0.066 12.9 0.0 1.4 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal HET PF06985.6 EWC44311.1 - 4.3e-05 23.7 0.1 9.6e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Cu-oxidase_2 PF07731.9 EWC44312.1 - 8.7e-40 135.4 2.3 1.6e-33 115.1 0.0 3.8 3 1 0 3 3 3 3 Multicopper oxidase Cu-oxidase_3 PF07732.10 EWC44312.1 - 9.5e-40 135.0 1.9 1.2e-38 131.4 1.7 2.3 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase PF00394.17 EWC44312.1 - 3.8e-33 114.6 0.0 6.3e-32 110.6 0.0 2.3 2 0 0 2 2 2 1 Multicopper oxidase COPI_C PF06957.6 EWC44313.1 - 0.09 11.3 1.4 0.12 10.8 0.9 1.1 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus adh_short PF00106.20 EWC44314.1 - 3.2e-20 72.6 0.1 1.8e-19 70.2 0.0 1.9 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.5 EWC44314.1 - 2.4e-12 46.8 0.0 5.2e-12 45.7 0.0 1.5 1 1 0 1 1 1 1 KR domain Epimerase PF01370.16 EWC44314.1 - 3.8e-09 36.3 0.0 5.6e-09 35.7 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family adh_short_C2 PF13561.1 EWC44314.1 - 3.3e-06 27.0 0.0 1.4e-05 25.0 0.0 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Shikimate_DH PF01488.15 EWC44314.1 - 0.00074 19.6 0.0 0.0014 18.7 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_10 PF13460.1 EWC44314.1 - 0.003 17.5 0.0 0.0091 16.0 0.0 1.8 2 0 0 2 2 2 1 NADH(P)-binding Polysacc_synt_2 PF02719.10 EWC44314.1 - 0.0035 16.2 0.0 0.0054 15.6 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.7 EWC44314.1 - 0.096 11.5 0.0 0.21 10.4 0.0 1.7 1 1 0 1 1 1 0 Male sterility protein LSPR PF06049.7 EWC44314.1 - 0.46 10.0 3.9 0.25 10.8 0.3 2.4 2 0 0 2 2 2 0 Coagulation Factor V LSPD Repeat Tyrosinase PF00264.15 EWC44315.1 - 5.2e-43 147.7 0.7 6.2e-43 147.5 0.5 1.1 1 0 0 1 1 1 1 Common central domain of tyrosinase Metallophos_2 PF12850.2 EWC44317.1 - 7e-08 32.4 0.0 1.3e-07 31.5 0.0 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.23 EWC44317.1 - 2.1e-07 30.5 1.0 3.8e-07 29.7 0.7 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Tautomerase_3 PF14832.1 EWC44318.1 - 7.2e-08 32.5 0.0 1e-07 32.0 0.0 1.3 1 0 0 1 1 1 1 Putative oxalocrotonate tautomerase enzyme Lysine_decarbox PF03641.9 EWC44319.1 - 3.6e-37 127.1 0.1 4.7e-37 126.7 0.0 1.1 1 0 0 1 1 1 1 Possible lysine decarboxylase S1-P1_nuclease PF02265.11 EWC44320.1 - 4.8e-65 219.6 0.0 5.5e-65 219.4 0.0 1.0 1 0 0 1 1 1 1 S1/P1 Nuclease RicinB_lectin_2 PF14200.1 EWC44321.1 - 0.0074 16.6 0.0 0.058 13.7 0.0 2.1 2 0 0 2 2 2 1 Ricin-type beta-trefoil lectin domain-like DUF3509 PF12021.3 EWC44321.1 - 0.058 13.1 0.6 0.54 10.0 0.1 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF3509) Romo1 PF10247.4 EWC44323.1 - 0.0065 16.6 0.5 1.9 8.7 0.0 2.8 3 0 0 3 3 3 2 Reactive mitochondrial oxygen species modulator 1 Tetraspannin PF00335.15 EWC44323.1 - 5.2 6.2 6.8 14 4.8 4.7 1.6 1 1 0 1 1 1 0 Tetraspanin family Synaptobrevin PF00957.16 EWC44324.1 - 2.4e-32 110.3 0.0 3.3e-32 109.9 0.0 1.2 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.1 EWC44324.1 - 5e-22 77.2 0.1 7.3e-22 76.7 0.1 1.2 1 0 0 1 1 1 1 Regulated-SNARE-like domain Glyco_hydro_17 PF00332.13 EWC44326.1 - 1.9e-12 46.8 0.2 3.3e-10 39.4 0.2 2.1 1 1 0 1 1 1 1 Glycosyl hydrolases family 17 CFEM PF05730.6 EWC44327.1 - 8.9e-06 25.4 4.0 8.9e-06 25.4 2.8 5.7 3 1 1 4 4 4 1 CFEM domain DUF2235 PF09994.4 EWC44330.1 - 3.3e-39 134.9 0.0 5.8e-39 134.1 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) SIS_2 PF13580.1 EWC44330.1 - 0.086 12.5 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 SIS domain V-ATPase_H_N PF03224.9 EWC44333.1 - 1.4e-66 224.7 0.0 2.5e-66 223.9 0.0 1.4 1 0 0 1 1 1 1 V-ATPase subunit H V-ATPase_H_C PF11698.3 EWC44333.1 - 3.5e-37 126.9 0.0 1.1e-35 122.0 0.0 2.4 2 0 0 2 2 2 1 V-ATPase subunit H HEAT PF02985.17 EWC44333.1 - 0.0048 16.8 0.0 0.086 12.9 0.0 2.9 2 0 0 2 2 2 1 HEAT repeat Arm PF00514.18 EWC44333.1 - 0.16 11.8 2.3 0.61 9.9 0.1 3.0 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat HrpB1_HrpK PF09613.5 EWC44333.1 - 0.16 11.4 0.4 0.33 10.4 0.0 1.6 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB1_HrpK) Pkinase PF00069.20 EWC44334.1 - 1.8e-20 73.1 0.0 3.9e-20 72.1 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC44334.1 - 4.4e-14 52.1 0.0 2.8e-12 46.2 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Aminotran_4 PF01063.14 EWC44335.1 - 4.3e-33 114.7 0.0 6.1e-33 114.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class IV Fungal_trans PF04082.13 EWC44336.1 - 2.7e-21 75.6 0.0 1.7e-20 73.0 0.0 2.1 1 1 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.21 EWC44336.1 - 4.1e-08 33.1 5.5 0.0022 18.2 0.1 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EWC44336.1 - 8.4e-07 28.8 3.9 0.0071 16.5 0.1 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 EWC44336.1 - 0.059 13.5 6.7 1.1 9.4 1.0 2.9 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 EWC44336.1 - 0.17 12.1 1.7 5.8 7.2 0.5 2.8 2 0 0 2 2 2 0 Zinc-finger of C2H2 type RRN7 PF11781.3 EWC44336.1 - 0.27 10.7 3.6 0.57 9.7 0.1 2.5 2 0 0 2 2 2 0 RNA polymerase I-specific transcription initiation factor Rrn7 zf-H2C2_2 PF13465.1 EWC44336.1 - 0.42 10.9 15.7 0.57 10.5 3.1 3.1 3 0 0 3 3 3 0 Zinc-finger double domain zf-BED PF02892.10 EWC44336.1 - 0.53 10.0 7.8 3.2 7.5 0.2 2.7 1 1 1 2 2 2 0 BED zinc finger RR_TM4-6 PF06459.7 EWC44337.1 - 0.12 12.3 0.8 0.16 11.8 0.6 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Mucin PF01456.12 EWC44337.1 - 0.22 11.2 11.6 0.38 10.5 8.0 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF3439 PF11921.3 EWC44337.1 - 0.23 11.1 2.4 0.33 10.7 1.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Dicty_REP PF05086.7 EWC44337.1 - 0.28 8.8 5.4 0.33 8.6 3.7 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Med3 PF11593.3 EWC44337.1 - 0.34 10.0 5.7 0.39 9.8 3.9 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal IpaC_SipC PF09599.5 EWC44338.1 - 0.097 11.6 4.4 0.18 10.7 3.0 1.4 1 0 0 1 1 1 0 Salmonella-Shigella invasin protein C (IpaC_SipC) BTB PF00651.26 EWC44339.1 - 4.1e-09 36.4 0.1 3.9e-08 33.2 0.0 2.2 2 1 1 3 3 3 1 BTB/POZ domain Ank PF00023.25 EWC44340.1 - 5.1e-13 48.1 0.0 0.008 15.9 0.0 3.7 3 0 0 3 3 3 3 Ankyrin repeat Ank_2 PF12796.2 EWC44340.1 - 1.7e-11 44.3 0.0 2.8e-10 40.4 0.0 2.8 1 1 2 3 3 3 2 Ankyrin repeats (3 copies) TPR_12 PF13424.1 EWC44340.1 - 5e-09 35.9 0.1 0.00091 19.1 0.0 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat Ank_3 PF13606.1 EWC44340.1 - 8.6e-07 28.6 0.1 0.0033 17.5 0.0 3.9 3 1 0 3 3 3 1 Ankyrin repeat TPR_11 PF13414.1 EWC44340.1 - 3.3e-05 23.4 0.4 0.00037 20.0 0.0 2.3 2 0 0 2 2 2 1 TPR repeat Ank_5 PF13857.1 EWC44340.1 - 3.7e-05 23.8 0.1 0.0011 19.1 0.0 2.8 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.1 EWC44340.1 - 5.9e-05 23.4 0.0 0.13 12.7 0.0 3.8 2 1 1 3 3 3 1 Ankyrin repeats (many copies) TPR_10 PF13374.1 EWC44340.1 - 0.00019 21.2 0.4 1.4 8.9 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 EWC44340.1 - 0.0095 15.7 0.2 2.1 8.4 0.0 3.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.1 EWC44340.1 - 0.023 15.3 0.5 0.17 12.6 0.0 2.6 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_19 PF14559.1 EWC44340.1 - 0.024 14.9 0.0 0.22 11.8 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat ATP_bind_2 PF03668.10 EWC44341.1 - 2.8e-05 23.3 0.0 0.0042 16.2 0.0 2.0 2 0 0 2 2 2 2 P-loop ATPase protein family DUF1043 PF06295.7 EWC44341.1 - 0.068 12.8 0.0 0.1 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) FAD_binding_4 PF01565.18 EWC44342.1 - 2.3e-25 88.6 2.0 4.1e-25 87.8 0.6 1.9 2 1 0 2 2 2 1 FAD binding domain BBE PF08031.7 EWC44342.1 - 0.0052 16.6 0.0 0.012 15.4 0.0 1.6 1 0 0 1 1 1 1 Berberine and berberine like PDZ_assoc PF10600.4 EWC44344.1 - 0.033 14.4 0.8 0.046 13.9 0.6 1.4 1 0 0 1 1 1 0 PDZ-associated domain of NMDA receptors DUF1183 PF06682.7 EWC44345.1 - 7 6.1 10.9 15 5.0 7.5 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1183) MFS_1 PF07690.11 EWC44346.1 - 5.3e-26 91.1 37.6 5.3e-26 91.1 26.0 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily YrhK PF14145.1 EWC44346.1 - 0.099 12.3 9.3 5.2 6.8 6.4 3.4 1 1 0 1 1 1 0 YrhK-like protein MFS_1 PF07690.11 EWC44347.1 - 2.1e-26 92.4 41.5 1.2e-14 53.8 19.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily OCC1 PF15506.1 EWC44347.1 - 0.073 12.9 0.3 0.17 11.7 0.2 1.6 1 0 0 1 1 1 0 OCC1 family Ribosomal_L6 PF00347.18 EWC44348.1 - 5e-26 91.0 10.2 6.1e-13 49.0 1.5 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 ESSS PF10183.4 EWC44350.1 - 2.4e-22 79.3 2.5 7.9e-22 77.6 0.1 2.1 2 0 0 2 2 2 1 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) MOSC_N PF03476.11 EWC44351.1 - 2.4e-18 65.9 0.0 4.1e-18 65.2 0.0 1.4 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain MOSC PF03473.12 EWC44351.1 - 2.9e-17 62.3 0.0 5.3e-17 61.5 0.0 1.4 1 0 0 1 1 1 1 MOSC domain Lipase_GDSL_3 PF14606.1 EWC44352.1 - 0.0018 18.0 0.0 0.0028 17.4 0.0 1.3 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family DUF3411 PF11891.3 EWC44353.1 - 0.025 14.2 0.0 0.044 13.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3411) Peptidase_M49 PF03571.10 EWC44354.1 - 9e-226 750.2 0.0 1.2e-225 749.8 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M49 DUF1311 PF07007.7 EWC44354.1 - 0.11 12.6 0.5 0.25 11.4 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1311) Myb_DNA-bind_4 PF13837.1 EWC44355.1 - 0.098 12.7 0.1 0.57 10.3 0.0 2.1 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain WSC PF01822.14 EWC44357.1 - 9.3e-58 192.1 93.6 1.3e-17 63.4 5.2 7.7 6 1 0 6 6 6 5 WSC domain PQQ_3 PF13570.1 EWC44357.1 - 6e-06 26.3 0.0 0.19 12.0 0.0 4.1 2 0 0 2 2 2 2 PQQ-like domain SOG2 PF10428.4 EWC44358.1 - 4.1 5.9 11.1 5.4 5.5 7.7 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Rad60-SLD PF11976.3 EWC44359.1 - 4.9e-22 77.4 0.1 6.1e-22 77.0 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.18 EWC44359.1 - 3.2e-10 39.2 0.0 4e-10 38.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin family SRP9-21 PF05486.7 EWC44359.1 - 0.06 13.0 0.1 0.078 12.7 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle 9 kDa protein (SRP9) DUF1903 PF08991.5 EWC44360.1 - 4.4e-26 90.8 9.7 5.7e-26 90.4 6.7 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1903) CHCH PF06747.8 EWC44360.1 - 0.0056 16.5 9.5 0.011 15.6 6.6 1.6 1 0 0 1 1 1 1 CHCH domain Nup84_Nup100 PF04121.8 EWC44361.1 - 1.3e-110 370.2 0.0 1.6e-110 369.9 0.0 1.1 1 0 0 1 1 1 1 Nuclear pore protein 84 / 107 TPR_4 PF07721.9 EWC44361.1 - 0.037 14.4 0.4 9.7 6.9 0.2 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat V-ATPase_C PF03223.10 EWC44362.1 - 6.2e-111 370.8 0.0 6.9e-111 370.7 0.0 1.0 1 0 0 1 1 1 1 V-ATPase subunit C tRNA-synt_2b PF00587.20 EWC44363.1 - 2.7e-35 121.5 0.0 4.4e-35 120.7 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 EWC44363.1 - 8.7e-11 41.6 0.5 1.6e-10 40.7 0.4 1.5 1 0 0 1 1 1 1 Anticodon binding domain GCV_T PF01571.16 EWC44364.1 - 8.6e-63 211.5 0.0 1.1e-62 211.1 0.0 1.2 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.6 EWC44364.1 - 1e-24 86.3 0.2 2.7e-24 85.0 0.2 1.8 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain SoxG PF04268.7 EWC44364.1 - 7e-06 25.9 0.0 3.1e-05 23.8 0.0 2.2 3 0 0 3 3 3 1 Sarcosine oxidase, gamma subunit family CBF PF03914.12 EWC44365.1 - 2.6e-48 163.5 0.2 2.6e-48 163.5 0.1 2.7 4 0 0 4 4 4 1 CBF/Mak21 family F-box-like PF12937.2 EWC44366.1 - 6.9e-05 22.4 0.0 0.00016 21.2 0.0 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EWC44366.1 - 0.16 11.6 1.8 3.6 7.3 1.3 2.6 1 1 0 1 1 1 0 F-box domain Aldedh PF00171.17 EWC44367.1 - 5.9e-108 361.1 0.0 7e-108 360.9 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Peptidase_S8 PF00082.17 EWC44368.1 - 4.6e-44 150.6 11.1 4.8e-27 94.8 2.9 2.2 2 0 0 2 2 2 2 Subtilase family DUF1034 PF06280.7 EWC44368.1 - 6.2e-12 45.9 0.0 2e-11 44.3 0.0 1.9 1 0 0 1 1 1 1 Fn3-like domain (DUF1034) PA PF02225.17 EWC44368.1 - 1.6e-07 30.9 0.3 6.3e-07 29.0 0.2 2.0 1 0 0 1 1 1 1 PA domain F-box-like PF12937.2 EWC44369.1 - 9.4e-11 41.2 0.2 1.3e-10 40.8 0.2 1.2 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EWC44369.1 - 0.00016 21.2 1.0 0.0012 18.4 0.7 2.2 1 1 0 1 1 1 1 F-box domain FAD_binding_4 PF01565.18 EWC44370.1 - 3.3e-20 71.9 4.7 3.6e-20 71.8 2.1 1.9 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.7 EWC44370.1 - 0.00085 19.1 0.0 0.0019 18.0 0.0 1.7 1 0 0 1 1 1 1 Berberine and berberine like AA_permease PF00324.16 EWC44371.1 - 1.9e-137 458.5 38.2 2.2e-137 458.2 26.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EWC44371.1 - 3.8e-41 141.0 42.9 4.9e-41 140.6 29.7 1.0 1 0 0 1 1 1 1 Amino acid permease Synaptobrevin PF00957.16 EWC44371.1 - 6.6 6.4 9.2 35 4.0 0.2 4.1 4 0 0 4 4 4 0 Synaptobrevin MFS_1 PF07690.11 EWC44372.1 - 5.9e-42 143.6 47.6 5.9e-42 143.6 33.0 1.9 2 0 0 2 2 2 1 Major Facilitator Superfamily Acetyltransf_3 PF13302.1 EWC44373.1 - 1.3e-15 57.8 0.0 1.6e-15 57.5 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 EWC44373.1 - 2.1e-05 24.4 0.0 3.6e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 EWC44373.1 - 0.00015 21.8 0.0 0.00021 21.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 EWC44373.1 - 0.00071 19.6 0.0 0.001 19.1 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 EWC44373.1 - 0.025 14.4 0.0 0.034 14.0 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain YcfA PF07927.7 EWC44373.1 - 6.5 6.7 5.3 11 6.0 0.0 2.6 2 1 1 3 3 3 0 YcfA-like protein Glyco_hydro_61 PF03443.9 EWC44375.1 - 5e-52 176.8 0.0 7.2e-52 176.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 bZIP_1 PF00170.16 EWC44376.1 - 0.4 10.6 12.5 0.72 9.8 8.6 1.3 1 0 0 1 1 1 0 bZIP transcription factor bZIP_2 PF07716.10 EWC44376.1 - 0.68 9.7 9.5 1.3 8.8 6.6 1.4 1 0 0 1 1 1 0 Basic region leucine zipper Sod_Fe_C PF02777.13 EWC44377.1 - 8.3e-31 105.9 0.2 1.3e-30 105.3 0.2 1.3 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.17 EWC44377.1 - 1.4e-24 86.1 9.9 1.4e-24 86.1 6.8 2.5 2 1 0 2 2 2 1 Iron/manganese superoxide dismutases, alpha-hairpin domain LPP PF04728.8 EWC44379.1 - 0.074 12.8 0.3 0.12 12.2 0.2 1.3 1 0 0 1 1 1 0 Lipoprotein leucine-zipper Glyoxalase_2 PF12681.2 EWC44380.1 - 3e-12 47.0 0.0 3.8e-12 46.7 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase PF00903.20 EWC44380.1 - 0.00016 21.6 0.0 0.0015 18.4 0.0 2.1 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.1 EWC44380.1 - 0.15 12.0 0.0 0.84 9.6 0.0 2.0 1 1 0 1 1 1 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Asp PF00026.18 EWC44381.1 - 5.8e-49 167.0 0.6 6.7e-49 166.8 0.4 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.1 EWC44381.1 - 2e-07 31.4 0.9 2.3e-05 24.7 0.2 2.8 2 1 0 2 2 2 1 Aspartyl protease TAXi_C PF14541.1 EWC44381.1 - 0.00021 20.8 0.1 0.0066 16.0 0.0 2.8 2 1 0 2 2 2 1 Xylanase inhibitor C-terminal gag-asp_proteas PF13975.1 EWC44381.1 - 0.0035 17.1 0.1 1.7 8.4 0.0 2.9 3 0 0 3 3 3 2 gag-polyprotein putative aspartyl protease DUF3443 PF11925.3 EWC44381.1 - 0.042 12.5 0.0 0.1 11.2 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3443) DUF4430 PF14478.1 EWC44381.1 - 0.67 10.0 7.1 0.34 10.9 2.7 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4430) NAD_binding_4 PF07993.7 EWC44382.1 - 0.0033 16.4 0.0 0.04 12.8 0.0 2.0 1 1 0 2 2 2 2 Male sterility protein FAD_binding_3 PF01494.14 EWC44383.1 - 3.7e-22 78.8 0.2 5.7e-22 78.2 0.2 1.2 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.19 EWC44383.1 - 4.8e-08 32.2 8.0 7.3e-05 21.8 0.1 2.4 1 1 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 EWC44383.1 - 4.9e-05 23.2 1.9 0.00036 20.4 1.1 2.4 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 EWC44383.1 - 6.9e-05 23.1 0.5 0.0061 16.9 0.6 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 EWC44383.1 - 7.2e-05 22.7 1.9 0.00014 21.7 0.9 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.9 EWC44383.1 - 9.8e-05 20.9 3.9 0.14 10.5 1.8 2.2 2 0 0 2 2 2 2 HI0933-like protein Trp_halogenase PF04820.9 EWC44383.1 - 0.0055 15.3 1.7 0.36 9.3 0.1 2.7 3 1 0 3 3 3 2 Tryptophan halogenase FAD_binding_2 PF00890.19 EWC44383.1 - 0.0063 15.4 6.3 0.013 14.4 2.9 2.2 1 1 1 2 2 2 1 FAD binding domain Lycopene_cycl PF05834.7 EWC44383.1 - 0.01 14.8 0.7 0.058 12.3 0.3 2.2 2 1 0 2 2 2 1 Lycopene cyclase protein AlaDh_PNT_C PF01262.16 EWC44383.1 - 0.022 14.3 0.7 0.056 13.0 0.3 1.8 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.17 EWC44383.1 - 0.083 11.7 0.1 0.13 11.0 0.1 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A IlvN PF07991.7 EWC44383.1 - 0.15 11.4 0.6 6.3 6.1 0.1 2.3 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, catalytic domain Cellulase PF00150.13 EWC44386.1 - 5e-23 81.7 0.2 8.5e-23 80.9 0.1 1.3 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) CBM_1 PF00734.13 EWC44386.1 - 1.2e-11 44.1 7.3 3.3e-11 42.6 5.0 1.9 1 0 0 1 1 1 1 Fungal cellulose binding domain Glyco_hydro_2_C PF02836.12 EWC44386.1 - 1.4e-06 27.4 0.0 7.4e-06 25.0 0.0 2.0 2 0 0 2 2 2 1 Glycosyl hydrolases family 2, TIM barrel domain Cellulase-like PF12876.2 EWC44386.1 - 9.5e-05 22.7 0.0 0.00034 21.0 0.0 2.0 1 0 0 1 1 1 1 Sugar-binding cellulase-like Glyco_hydro_42 PF02449.10 EWC44386.1 - 0.00023 20.4 0.1 0.0015 17.7 0.0 2.2 2 1 0 2 2 2 1 Beta-galactosidase Glyco_hydro_10 PF00331.15 EWC44386.1 - 0.013 14.5 0.0 0.028 13.4 0.0 1.5 1 0 0 1 1 1 0 Glycosyl hydrolase family 10 CENP-T PF15511.1 EWC44387.1 - 0.00048 19.5 10.7 0.00078 18.7 7.4 1.4 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T CDC45 PF02724.9 EWC44387.1 - 0.2 9.6 17.7 0.32 8.9 12.3 1.3 1 0 0 1 1 1 0 CDC45-like protein Daxx PF03344.10 EWC44387.1 - 0.49 8.8 20.4 0.72 8.2 14.2 1.2 1 0 0 1 1 1 0 Daxx Family SDA1 PF05285.7 EWC44387.1 - 0.87 8.8 25.3 1.4 8.1 17.5 1.2 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.7 EWC44387.1 - 1.6 6.5 30.5 2.3 6.0 21.1 1.1 1 0 0 1 1 1 0 Nop14-like family PPP4R2 PF09184.6 EWC44387.1 - 6.4 6.2 21.1 10 5.5 14.6 1.2 1 0 0 1 1 1 0 PPP4R2 MFS_1 PF07690.11 EWC44389.1 - 1.2e-30 106.4 45.0 4.7e-28 97.9 29.2 2.6 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.8 EWC44389.1 - 2.3e-13 49.2 6.2 3.7e-13 48.5 4.3 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.19 EWC44389.1 - 4.3e-09 35.4 6.9 4.3e-09 35.4 4.8 2.3 3 0 0 3 3 3 1 Sugar (and other) transporter DUF4131 PF13567.1 EWC44389.1 - 0.0091 15.4 0.6 0.0091 15.4 0.4 3.2 3 1 1 4 4 4 1 Domain of unknown function (DUF4131) FTA4 PF13093.1 EWC44391.1 - 0.024 14.0 0.5 0.033 13.6 0.3 1.1 1 0 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 SOG2 PF10428.4 EWC44391.1 - 0.1 11.2 1.0 0.15 10.7 0.7 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein bZIP_1 PF00170.16 EWC44391.1 - 0.8 9.7 5.6 0.68 9.9 2.5 1.7 1 1 1 2 2 2 0 bZIP transcription factor DUF2235 PF09994.4 EWC44392.1 - 4.9e-65 219.6 0.0 6.1e-65 219.3 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) FUSC-like PF12805.2 EWC44393.1 - 0.14 11.0 0.3 0.2 10.5 0.2 1.2 1 0 0 1 1 1 0 FUSC-like inner membrane protein yccS Dabb PF07876.7 EWC44397.1 - 4.6e-13 49.4 0.0 5.1e-13 49.2 0.0 1.0 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain HCO3_cotransp PF00955.16 EWC44398.1 - 1.5e-61 208.6 8.3 5.1e-33 114.5 2.4 2.1 1 1 1 2 2 2 2 HCO3- transporter family Tyrosinase PF00264.15 EWC44400.1 - 6.4e-52 176.9 7.0 6.4e-52 176.9 4.9 1.5 2 0 0 2 2 2 1 Common central domain of tyrosinase SNARE_assoc PF09335.6 EWC44401.1 - 1.5e-17 63.9 9.2 1.5e-17 63.9 6.3 2.4 3 0 0 3 3 3 1 SNARE associated Golgi protein DUF2668 PF10873.3 EWC44401.1 - 0.23 11.6 0.9 0.54 10.4 0.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2668) DUF2681 PF10883.3 EWC44401.1 - 0.75 10.0 0.0 0.75 10.0 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2681) SieB PF14163.1 EWC44401.1 - 2.2 7.8 7.7 5.6 6.5 0.1 2.8 2 1 1 3 3 3 0 Superinfection exclusion protein B DUF1049 PF06305.6 EWC44401.1 - 9.7 5.7 9.0 1.7 8.1 0.0 3.4 3 1 0 3 3 3 0 Protein of unknown function (DUF1049) Glyco_hydro_3 PF00933.16 EWC44403.1 - 1.3e-86 290.2 0.1 2.4e-86 289.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.17 EWC44403.1 - 3.2e-57 193.6 0.3 3.2e-57 193.6 0.2 2.1 2 0 0 2 2 2 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.1 EWC44403.1 - 5e-24 84.0 0.0 9.4e-24 83.1 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain CBM_1 PF00734.13 EWC44403.1 - 4.1e-10 39.1 6.2 1.2e-09 37.6 4.3 1.9 1 0 0 1 1 1 1 Fungal cellulose binding domain WSC PF01822.14 EWC44404.1 - 1.2e-14 53.9 11.2 5.2e-11 42.3 5.3 2.8 2 0 0 2 2 2 2 WSC domain PQQ_3 PF13570.1 EWC44404.1 - 0.023 14.9 0.0 0.023 14.9 0.0 4.0 5 0 0 5 5 5 0 PQQ-like domain PapD_N PF00345.15 EWC44404.1 - 0.22 11.3 0.2 0.43 10.3 0.2 1.4 1 0 0 1 1 1 0 Pili and flagellar-assembly chaperone, PapD N-terminal domain Aldo_ket_red PF00248.16 EWC44405.1 - 7.5e-60 202.1 0.0 9.5e-60 201.8 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Metallophos PF00149.23 EWC44406.1 - 3.1e-15 56.1 0.0 5.2e-15 55.3 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 EWC44406.1 - 1.7e-06 27.9 0.0 4.3e-06 26.6 0.0 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Pyridoxal_deC PF00282.14 EWC44407.1 - 1.1e-78 264.3 0.0 1.5e-78 263.8 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain adh_short PF00106.20 EWC44408.1 - 9.6e-30 103.6 1.0 1.2e-29 103.3 0.7 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EWC44408.1 - 3.9e-18 66.0 0.0 5.3e-18 65.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EWC44408.1 - 3e-13 49.8 0.4 4.5e-13 49.2 0.3 1.2 1 0 0 1 1 1 1 KR domain LT-IIB PF06453.6 EWC44408.1 - 0.086 12.5 0.0 0.59 9.8 0.0 2.2 2 0 0 2 2 2 0 Type II heat-labile enterotoxin , B subunit (LT-IIB) His_Phos_2 PF00328.17 EWC44409.1 - 2.3e-53 181.7 0.0 2.7e-53 181.5 0.0 1.0 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) gp37_C PF12604.3 EWC44410.1 - 0.082 12.6 1.0 0.15 11.8 0.7 1.3 1 0 0 1 1 1 0 Tail fiber protein gp37 C terminal COesterase PF00135.23 EWC44411.1 - 2.1e-70 237.9 0.0 2.7e-70 237.5 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 EWC44411.1 - 1.9e-05 24.3 0.1 8.8e-05 22.1 0.1 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 EWC44411.1 - 0.00031 20.0 0.1 0.00048 19.4 0.1 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family DUF2424 PF10340.4 EWC44411.1 - 0.0026 16.4 0.0 0.0065 15.1 0.0 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF2424) Abhydrolase_5 PF12695.2 EWC44411.1 - 0.063 13.0 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family CAP PF00188.21 EWC44412.1 - 1.6e-22 80.2 5.7 2.2e-22 79.8 4.0 1.2 1 0 0 1 1 1 1 Cysteine-rich secretory protein family DUF829 PF05705.9 EWC44413.1 - 1.5e-34 119.7 0.0 1.8e-34 119.5 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF829) NMO PF03060.10 EWC44413.1 - 0.061 12.4 0.1 0.092 11.8 0.1 1.2 1 0 0 1 1 1 0 Nitronate monooxygenase Glyco_hydro_17 PF00332.13 EWC44414.1 - 1.7e-14 53.5 1.6 4.9e-14 52.0 1.1 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 17 LRR_8 PF13855.1 EWC44415.1 - 1.1e-11 44.3 0.6 0.00049 19.8 0.0 3.5 2 2 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.2 EWC44415.1 - 3.1e-11 42.6 0.1 0.0014 18.1 0.0 4.3 2 1 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 EWC44415.1 - 6.8e-08 31.4 0.7 1.8 9.1 0.1 6.4 7 0 0 7 7 7 2 Leucine rich repeat LRR_1 PF00560.28 EWC44415.1 - 1.9e-07 30.1 1.4 1.4 9.1 0.1 6.3 6 1 1 7 7 7 2 Leucine Rich Repeat LRR_6 PF13516.1 EWC44415.1 - 0.13 12.4 2.7 8.4 6.8 0.1 4.1 4 1 1 5 5 5 0 Leucine Rich repeat FKBP_C PF00254.23 EWC44417.1 - 4.2e-31 106.8 0.0 4.7e-31 106.6 0.0 1.0 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase His_Phos_1 PF00300.17 EWC44418.1 - 8.5e-21 74.6 0.0 1.2e-20 74.2 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) ZZ PF00569.12 EWC44419.1 - 0.00013 21.3 6.7 0.00024 20.5 4.7 1.4 1 0 0 1 1 1 1 Zinc finger, ZZ type HypA PF01155.14 EWC44419.1 - 0.092 12.4 1.9 0.17 11.5 1.3 1.4 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family Sgf11 PF08209.6 EWC44419.1 - 0.11 11.8 3.3 0.16 11.3 0.2 2.4 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) AAR2 PF05282.6 EWC44420.1 - 1.3e-50 172.3 0.0 2.1e-50 171.6 0.0 1.3 1 0 0 1 1 1 1 AAR2 protein Ribosomal_S9 PF00380.14 EWC44421.1 - 9.5e-39 132.3 0.1 1.1e-38 132.2 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Nckap1 PF09735.4 EWC44421.1 - 0.13 9.7 0.0 0.14 9.5 0.0 1.0 1 0 0 1 1 1 0 Membrane-associated apoptosis protein Med27 PF11571.3 EWC44422.1 - 2.3e-11 43.6 0.2 9.6e-11 41.6 0.0 2.0 2 0 0 2 2 2 1 Mediator complex subunit 27 Orn_Arg_deC_N PF02784.11 EWC44423.1 - 9e-59 198.6 0.0 1.1e-58 198.3 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.17 EWC44423.1 - 1.3e-20 73.2 0.0 2.6e-20 72.2 0.0 1.5 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Ribosomal_S11 PF00411.14 EWC44424.1 - 1.2e-39 134.9 0.5 1.4e-39 134.6 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 AA_permease_2 PF13520.1 EWC44425.1 - 4.2e-60 203.4 46.9 5.5e-60 203.0 32.5 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EWC44425.1 - 5.1e-22 77.8 42.0 7.1e-22 77.3 29.1 1.1 1 0 0 1 1 1 1 Amino acid permease TPR_12 PF13424.1 EWC44427.1 - 1.2e-34 118.0 11.9 6.1e-12 45.3 0.1 6.2 5 2 2 7 7 7 5 Tetratricopeptide repeat TPR_10 PF13374.1 EWC44427.1 - 1.1e-30 104.5 13.6 2.3e-06 27.3 0.0 7.9 8 1 0 8 8 8 5 Tetratricopeptide repeat TPR_11 PF13414.1 EWC44427.1 - 1.1e-15 57.0 3.1 1.2e-05 24.8 0.3 4.8 3 1 1 4 4 4 4 TPR repeat TPR_2 PF07719.12 EWC44427.1 - 1.5e-11 43.2 8.7 0.0052 16.5 1.0 6.2 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.23 EWC44427.1 - 5.1e-10 38.5 13.0 0.0013 18.2 0.9 7.2 7 1 0 7 7 7 2 Tetratricopeptide repeat NB-ARC PF00931.17 EWC44427.1 - 1.5e-08 33.8 0.0 1.1e-07 30.9 0.0 2.2 1 1 0 1 1 1 1 NB-ARC domain TPR_8 PF13181.1 EWC44427.1 - 1.7e-08 33.6 7.3 0.1 12.4 0.0 5.5 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_16 PF13432.1 EWC44427.1 - 2.2e-08 34.5 21.6 0.00019 22.0 1.8 6.3 6 1 2 8 8 6 4 Tetratricopeptide repeat TPR_19 PF14559.1 EWC44427.1 - 4.6e-08 33.2 7.0 0.0014 18.9 0.2 5.4 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.1 EWC44427.1 - 6.4e-08 31.8 4.3 0.097 12.5 0.2 5.2 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_14 PF13428.1 EWC44427.1 - 1.2e-07 31.7 16.9 0.056 14.0 0.6 6.7 5 2 2 7 7 5 3 Tetratricopeptide repeat TPR_6 PF13174.1 EWC44427.1 - 6.1e-07 29.4 11.7 0.25 11.8 0.7 6.7 7 0 0 7 7 5 2 Tetratricopeptide repeat AAA_22 PF13401.1 EWC44427.1 - 5e-06 26.6 0.2 8.6e-05 22.6 0.0 3.1 3 1 0 3 3 2 1 AAA domain TPR_4 PF07721.9 EWC44427.1 - 6.4e-06 26.1 7.0 0.34 11.4 0.1 6.2 6 0 0 6 6 4 1 Tetratricopeptide repeat Apc3 PF12895.2 EWC44427.1 - 0.00025 21.1 5.1 0.039 14.0 0.1 4.3 4 1 0 4 4 3 1 Anaphase-promoting complex, cyclosome, subunit 3 NACHT PF05729.7 EWC44427.1 - 0.00027 20.6 0.0 0.0012 18.5 0.0 2.0 2 0 0 2 2 2 1 NACHT domain TPR_17 PF13431.1 EWC44427.1 - 0.0006 19.7 0.5 6.5 7.2 0.2 4.8 4 0 0 4 4 4 0 Tetratricopeptide repeat PGAP1 PF07819.8 EWC44427.1 - 0.0047 16.5 0.0 0.009 15.6 0.0 1.4 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_6 PF12697.2 EWC44427.1 - 0.0068 16.3 0.2 0.027 14.3 0.0 2.1 2 0 0 2 2 2 1 Alpha/beta hydrolase family IstB_IS21 PF01695.12 EWC44427.1 - 0.012 15.0 0.0 0.026 13.9 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_19 PF13245.1 EWC44427.1 - 0.019 14.7 0.0 0.077 12.7 0.0 2.0 1 0 0 1 1 1 0 Part of AAA domain KTI12 PF08433.5 EWC44427.1 - 0.047 12.8 0.0 0.13 11.4 0.0 1.6 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_17 PF13207.1 EWC44427.1 - 0.086 13.6 0.0 0.37 11.6 0.0 2.1 1 0 0 1 1 1 0 AAA domain PhoH PF02562.11 EWC44427.1 - 0.11 11.7 0.0 0.21 10.8 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein TPR_3 PF07720.7 EWC44427.1 - 0.13 12.1 8.7 4.6 7.1 1.9 4.8 5 0 0 5 5 5 0 Tetratricopeptide repeat Ank_2 PF12796.2 EWC44428.1 - 2.2e-45 152.9 19.5 1.7e-11 44.2 0.1 11.5 5 4 5 10 10 10 8 Ankyrin repeats (3 copies) Ank PF00023.25 EWC44428.1 - 5.7e-21 73.2 26.9 0.1 12.4 0.0 15.6 17 1 0 17 17 17 8 Ankyrin repeat Ank_3 PF13606.1 EWC44428.1 - 1.1e-15 56.2 12.7 1.8 9.0 0.0 14.9 17 0 0 17 17 17 2 Ankyrin repeat Ank_4 PF13637.1 EWC44428.1 - 9.4e-15 54.6 5.2 0.0068 16.8 0.0 10.1 11 2 3 14 14 14 4 Ankyrin repeats (many copies) Ank_5 PF13857.1 EWC44428.1 - 1.1e-10 41.3 10.2 0.057 13.6 0.0 8.8 9 1 1 10 10 10 4 Ankyrin repeats (many copies) Amidase PF01425.16 EWC44431.1 - 3.3e-89 299.7 0.0 3.9e-89 299.5 0.0 1.1 1 0 0 1 1 1 1 Amidase FPN1 PF06963.7 EWC44432.1 - 1.6e-20 72.9 0.1 3.2e-17 62.0 0.0 2.0 2 0 0 2 2 2 2 Ferroportin1 (FPN1) Ferric_reduct PF01794.14 EWC44433.1 - 9.8e-20 70.9 8.8 1.5e-19 70.3 4.8 2.1 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.7 EWC44433.1 - 1.1e-18 67.6 0.0 6.6e-12 45.6 0.0 2.3 1 1 1 2 2 2 2 Ferric reductase NAD binding domain FAD_binding_8 PF08022.7 EWC44433.1 - 4.8e-15 55.3 0.0 1.5e-10 40.8 0.1 2.4 2 0 0 2 2 2 2 FAD-binding domain Chs3p PF12271.3 EWC44433.1 - 0.0049 15.8 0.7 2.6 6.9 0.2 2.3 2 0 0 2 2 2 2 Chitin synthase III catalytic subunit NAD_binding_1 PF00175.16 EWC44433.1 - 0.13 12.8 0.0 0.33 11.5 0.0 1.7 1 1 0 1 1 1 0 Oxidoreductase NAD-binding domain Vps39_2 PF10367.4 EWC44434.1 - 1.4e-07 31.6 0.0 3.3e-07 30.4 0.0 1.6 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 Clathrin PF00637.15 EWC44434.1 - 0.0026 17.3 0.1 0.036 13.6 0.0 2.8 4 0 0 4 4 4 1 Region in Clathrin and VPS CASP_C PF08172.7 EWC44435.1 - 8e-79 264.1 0.6 8e-79 264.1 0.4 5.0 3 1 3 6 6 6 2 CASP C terminal Atg14 PF10186.4 EWC44435.1 - 0.0012 17.8 49.6 0.01 14.8 9.0 4.9 4 1 0 4 4 4 3 UV radiation resistance protein and autophagy-related subunit 14 Hemerythrin PF01814.18 EWC44435.1 - 0.0033 17.5 9.4 1.1 9.3 0.2 3.7 3 0 0 3 3 3 2 Hemerythrin HHE cation binding domain DUF972 PF06156.8 EWC44435.1 - 0.058 13.7 35.0 0.68 10.3 2.7 6.0 4 1 1 5 5 5 0 Protein of unknown function (DUF972) bZIP_2 PF07716.10 EWC44435.1 - 0.36 10.7 55.1 0.093 12.5 1.7 8.1 6 3 2 9 9 9 0 Basic region leucine zipper Baculo_PEP_C PF04513.7 EWC44435.1 - 0.57 10.0 21.5 7.8 6.3 0.8 4.6 4 0 0 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Nup54 PF13874.1 EWC44435.1 - 3 7.5 38.7 0.22 11.1 0.1 5.5 4 1 1 5 5 5 0 Nucleoporin complex subunit 54 ATG16 PF08614.6 EWC44435.1 - 3.9 7.2 56.0 0.4 10.4 0.2 5.4 2 1 2 5 5 5 0 Autophagy protein 16 (ATG16) Fib_alpha PF08702.5 EWC44435.1 - 4 7.5 33.1 1.5 8.8 0.1 5.0 4 1 2 6 6 6 0 Fibrinogen alpha/beta chain family FlaC_arch PF05377.6 EWC44435.1 - 4.8 7.1 27.7 0.57 10.1 0.4 6.5 5 1 0 5 5 5 0 Flagella accessory protein C (FlaC) bZIP_1 PF00170.16 EWC44435.1 - 7.1 6.6 51.0 0.034 14.0 2.6 7.3 6 1 1 7 7 7 0 bZIP transcription factor DivIC PF04977.10 EWC44435.1 - 9.4 5.7 49.7 0.072 12.5 1.4 6.6 5 1 2 7 7 7 0 Septum formation initiator Polysacc_lyase PF14099.1 EWC44436.1 - 0.0052 16.4 0.0 0.0068 16.0 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide lyase Ribosomal_L22 PF00237.14 EWC44437.1 - 7.6e-37 125.4 0.5 1.6e-36 124.4 0.0 1.6 2 0 0 2 2 2 1 Ribosomal protein L22p/L17e Fibrillarin PF01269.12 EWC44438.1 - 4e-107 356.3 0.0 4.8e-107 356.1 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.5 EWC44438.1 - 9.5e-06 25.2 0.0 1.4e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltransf_31 PF13847.1 EWC44438.1 - 0.0079 15.7 0.0 0.01 15.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 EWC44438.1 - 0.14 11.6 0.0 0.21 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Fasciclin PF02469.17 EWC44439.1 - 1.5e-28 99.3 0.0 4.4e-14 52.5 0.0 2.5 2 1 0 2 2 2 2 Fasciclin domain PDH PF02153.12 EWC44440.1 - 1.3e-15 57.0 0.0 1.8e-15 56.5 0.0 1.2 1 0 0 1 1 1 1 Prephenate dehydrogenase F420_oxidored PF03807.12 EWC44440.1 - 1.4e-07 31.8 0.0 3.2e-07 30.6 0.0 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.10 EWC44440.1 - 2.4e-06 27.4 0.0 4.2e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.14 EWC44440.1 - 1.5e-05 24.2 0.0 2.7e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ApbA PF02558.11 EWC44440.1 - 4e-05 23.1 0.0 6.6e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA TrkA_N PF02254.13 EWC44440.1 - 0.003 17.5 0.0 0.0063 16.4 0.0 1.5 1 0 0 1 1 1 1 TrkA-N domain 3HCDH_N PF02737.13 EWC44440.1 - 0.0038 16.9 0.0 0.0064 16.1 0.0 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain IlvN PF07991.7 EWC44440.1 - 0.0094 15.3 0.0 0.017 14.5 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain Rossmann-like PF10727.4 EWC44440.1 - 0.02 14.6 0.0 0.044 13.5 0.0 1.5 1 0 0 1 1 1 0 Rossmann-like domain Shikimate_DH PF01488.15 EWC44440.1 - 0.077 13.0 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Peptidase_C12 PF01088.16 EWC44443.1 - 7.6e-71 237.6 0.0 2.7e-70 235.8 0.0 1.7 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase, family 1 Cutinase PF01083.17 EWC44444.1 - 1.3e-53 181.3 8.6 1.3e-53 181.3 5.9 1.5 2 0 0 2 2 2 1 Cutinase CBM_1 PF00734.13 EWC44444.1 - 4.5e-10 39.0 18.3 4.5e-10 39.0 12.7 5.3 4 2 0 4 4 4 1 Fungal cellulose binding domain Mucin PF01456.12 EWC44444.1 - 0.0025 17.6 35.1 0.0025 17.6 24.3 2.0 2 1 0 2 2 2 1 Mucin-like glycoprotein PE-PPE PF08237.6 EWC44444.1 - 0.0075 15.7 0.2 0.0075 15.7 0.1 2.3 2 1 0 2 2 2 1 PE-PPE domain VirJ PF06057.6 EWC44444.1 - 0.069 12.9 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 Bacterial virulence protein (VirJ) Sporozoite_P67 PF05642.6 EWC44444.1 - 0.64 7.8 10.9 0.9 7.3 7.6 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Dicty_REP PF05086.7 EWC44444.1 - 7.8 4.1 12.4 11 3.5 8.6 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein ATG27 PF09451.5 EWC44446.1 - 1.8e-55 188.1 0.0 2.2e-55 187.7 0.0 1.1 1 0 0 1 1 1 1 Autophagy-related protein 27 CIMR PF00878.13 EWC44446.1 - 0.13 12.0 0.0 0.56 9.9 0.0 1.9 2 0 0 2 2 2 0 Cation-independent mannose-6-phosphate receptor repeat Cation_efflux PF01545.16 EWC44447.1 - 4.7e-30 104.6 4.2 5.7e-30 104.3 2.9 1.1 1 0 0 1 1 1 1 Cation efflux family Prefoldin_2 PF01920.15 EWC44448.1 - 1.4e-20 72.9 0.5 1.7e-20 72.7 0.3 1.1 1 0 0 1 1 1 1 Prefoldin subunit DUF465 PF04325.8 EWC44448.1 - 0.03 14.0 0.6 0.03 14.0 0.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF465) ApbA_C PF08546.6 EWC44448.1 - 0.15 12.0 0.3 1.7 8.6 0.0 2.0 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA C terminal Nucleoporin_FG PF13634.1 EWC44449.1 - 1.9e-07 31.3 2.9 2.6e-07 30.8 2.0 1.2 1 0 0 1 1 1 1 Nucleoporin FG repeat region DDRGK PF09756.4 EWC44452.1 - 6.7e-05 22.3 11.7 0.21 10.9 0.0 2.2 2 0 0 2 2 2 2 DDRGK domain NAM-associated PF14303.1 EWC44452.1 - 1.1 9.5 10.3 2.1 8.6 7.2 1.4 1 1 0 1 1 1 0 No apical meristem-associated C-terminal domain Nucleoporin_FG PF13634.1 EWC44453.1 - 5.8e-08 32.9 135.6 1.3e-05 25.4 20.4 7.7 2 1 5 7 7 7 4 Nucleoporin FG repeat region Methyltransf_23 PF13489.1 EWC44454.1 - 4.2e-13 49.3 0.1 8e-13 48.4 0.1 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EWC44454.1 - 5.3e-08 33.4 0.0 8.5e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EWC44454.1 - 2.7e-07 30.3 0.0 3.7e-07 29.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EWC44454.1 - 2.9e-07 30.8 0.0 6e-07 29.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EWC44454.1 - 1.8e-06 28.3 0.0 3.6e-06 27.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EWC44454.1 - 7.1e-06 26.3 0.0 1.6e-05 25.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EWC44454.1 - 2.2e-05 24.4 0.3 3.6e-05 23.7 0.2 1.5 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EWC44454.1 - 0.012 15.0 0.0 0.017 14.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Zip PF02535.17 EWC44454.1 - 1.3 7.9 11.9 1.8 7.4 8.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Acetyltransf_1 PF00583.19 EWC44455.1 - 2e-06 27.7 0.0 3.5e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 EWC44455.1 - 2e-05 24.6 0.0 3.3e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_5 PF13444.1 EWC44455.1 - 0.0022 18.5 0.0 0.04 14.4 0.0 2.9 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.1 EWC44455.1 - 0.026 14.3 0.0 0.046 13.5 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase DUF3973 PF13119.1 EWC44455.1 - 0.092 12.6 0.0 0.22 11.4 0.0 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3973) Sec63 PF02889.11 EWC44457.1 - 2.8e-35 122.0 0.0 5.8e-35 121.0 0.0 1.5 1 1 0 1 1 1 1 Sec63 Brl domain DnaJ PF00226.26 EWC44457.1 - 1.3e-18 66.4 0.2 2.7e-18 65.4 0.1 1.6 1 0 0 1 1 1 1 DnaJ domain Thaumatin PF00314.12 EWC44458.1 - 1.6e-49 168.2 0.0 4.3e-47 160.3 0.0 2.1 1 1 0 1 1 1 1 Thaumatin family Chorion_3 PF05387.6 EWC44459.1 - 0.2 11.0 5.8 0.23 10.8 4.0 1.2 1 0 0 1 1 1 0 Chorion family 3 Methyltransf_PK PF05891.7 EWC44461.1 - 2.6e-75 252.4 0.0 7.6e-75 250.9 0.0 1.6 1 1 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_23 PF13489.1 EWC44461.1 - 0.00068 19.3 0.0 0.00093 18.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EWC44461.1 - 0.075 13.5 0.0 0.2 12.1 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain ADH_N PF08240.7 EWC44463.1 - 1.6e-27 95.3 0.2 2.9e-27 94.5 0.2 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 EWC44463.1 - 2.2e-13 49.9 0.2 9.7e-11 41.3 0.1 2.3 1 1 1 2 2 2 2 Zinc-binding dehydrogenase NAD_binding_10 PF13460.1 EWC44463.1 - 0.034 14.1 0.3 0.06 13.3 0.2 1.4 1 0 0 1 1 1 0 NADH(P)-binding TPT PF03151.11 EWC44464.1 - 1.4e-14 54.0 13.0 1.4e-14 54.0 9.0 2.4 2 1 0 2 2 2 1 Triose-phosphate Transporter family EamA PF00892.15 EWC44464.1 - 2.9e-05 24.0 13.1 2.9e-05 24.0 9.1 2.8 2 2 0 2 2 2 1 EamA-like transporter family Inositol_P PF00459.20 EWC44465.1 - 7.9e-51 172.9 1.2 5.9e-50 170.0 0.8 1.9 1 1 0 1 1 1 1 Inositol monophosphatase family DUF2823 PF11034.3 EWC44466.1 - 2.2e-14 53.2 1.9 2.8e-14 52.9 1.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2823) DUF802 PF05650.6 EWC44466.1 - 0.043 13.9 0.0 0.2 11.8 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF802) Pectate_lyase PF03211.8 EWC44467.1 - 1.1e-76 256.9 3.3 1.8e-76 256.3 2.3 1.2 1 0 0 1 1 1 1 Pectate lyase CBM_1 PF00734.13 EWC44467.1 - 4.1e-12 45.5 12.8 4.1e-12 45.5 8.9 3.0 3 0 0 3 3 3 1 Fungal cellulose binding domain SR-25 PF10500.4 EWC44469.1 - 5.8 6.3 11.7 7.6 5.9 8.1 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Cep57_MT_bd PF06657.8 EWC44470.1 - 5.1e-24 84.0 0.9 5.1e-24 84.0 0.6 4.5 6 0 0 6 6 6 1 Centrosome microtubule-binding domain of Cep57 Rootletin PF15035.1 EWC44470.1 - 0.0012 18.8 17.2 0.0012 18.8 11.9 4.9 5 2 0 6 6 6 1 Ciliary rootlet component, centrosome cohesion Rab5-bind PF09311.6 EWC44470.1 - 0.0013 18.6 18.4 0.0013 18.6 12.7 4.9 5 0 0 5 5 5 1 Rabaptin-like protein Filament PF00038.16 EWC44470.1 - 4.5 6.6 48.5 0.023 14.1 11.6 4.6 4 1 1 5 5 5 0 Intermediate filament protein HATPase_c PF02518.21 EWC44471.1 - 4.5e-30 103.6 0.4 1e-29 102.4 0.3 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase AAA_16 PF13191.1 EWC44471.1 - 5.6e-29 101.4 0.1 1.4e-28 100.1 0.1 1.7 1 0 0 1 1 1 1 AAA ATPase domain Response_reg PF00072.19 EWC44471.1 - 2.3e-26 91.9 1.0 4.4e-24 84.6 0.1 3.4 3 0 0 3 3 3 1 Response regulator receiver domain HisKA PF00512.20 EWC44471.1 - 8.9e-16 57.6 0.2 4.9e-15 55.2 0.0 2.5 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain GAF_2 PF13185.1 EWC44471.1 - 1.2e-11 45.2 0.0 6.4e-10 39.6 0.0 2.6 2 0 0 2 2 2 1 GAF domain GAF PF01590.21 EWC44471.1 - 2.2e-11 44.1 0.0 5.7e-11 42.7 0.0 1.8 1 0 0 1 1 1 1 GAF domain Pkinase PF00069.20 EWC44471.1 - 1.3e-10 40.9 0.0 2.6e-10 39.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain GAF_3 PF13492.1 EWC44471.1 - 4.9e-08 33.1 0.0 2e-07 31.1 0.0 2.2 2 0 0 2 2 2 1 GAF domain Pkinase_Tyr PF07714.12 EWC44471.1 - 1.2e-05 24.4 0.0 3.2e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 Protein tyrosine kinase AAA_22 PF13401.1 EWC44471.1 - 0.00081 19.5 0.2 0.0034 17.5 0.0 2.2 2 0 0 2 2 2 1 AAA domain DUF258 PF03193.11 EWC44471.1 - 0.039 13.1 0.1 0.085 12.0 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 Cyclin PF08613.6 EWC44472.1 - 4.7e-32 111.4 0.1 1.1e-31 110.2 0.1 1.7 1 1 0 1 1 1 1 Cyclin Cyclin_N PF00134.18 EWC44472.1 - 0.00063 19.2 0.1 0.0012 18.3 0.1 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain FluMu_gp41 PF10109.4 EWC44472.1 - 0.069 13.0 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 Mu-like prophage FluMu protein gp41 HTH_3 PF01381.17 EWC44472.1 - 0.12 12.2 0.0 0.34 10.7 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix KRE9 PF05390.6 EWC44473.1 - 2.8e-18 66.2 2.1 2.8e-18 66.2 1.5 1.7 2 0 0 2 2 2 1 Yeast cell wall synthesis protein KRE9/KNH1 GPI-anchored PF10342.4 EWC44473.1 - 2.4e-16 59.9 0.7 5e-16 58.9 0.1 1.8 2 0 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Peptidase_M24 PF00557.19 EWC44474.1 - 1.5e-53 181.4 0.0 2e-53 181.0 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.11 EWC44474.1 - 1.1e-21 76.6 0.0 2e-21 75.8 0.0 1.4 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain Spore_III_AF PF09581.5 EWC44476.1 - 4.1 7.2 11.8 0.19 11.5 2.2 2.1 2 0 0 2 2 2 0 Stage III sporulation protein AF (Spore_III_AF) CBM_1 PF00734.13 EWC44477.1 - 1.9e-13 49.8 13.1 1.9e-13 49.8 9.1 2.0 2 0 0 2 2 2 1 Fungal cellulose binding domain Macoilin PF09726.4 EWC44477.1 - 0.12 10.6 3.6 0.13 10.5 2.5 1.1 1 0 0 1 1 1 0 Transmembrane protein DUF566 PF04484.7 EWC44477.1 - 0.6 9.5 8.4 0.84 9.0 5.8 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF566) Metallopep PF12044.3 EWC44477.1 - 0.86 7.9 6.1 0.063 11.7 0.2 1.8 2 0 0 2 2 2 0 Putative peptidase family PAP1 PF08601.5 EWC44477.1 - 1.5 8.4 11.8 3.1 7.3 8.2 1.4 1 0 0 1 1 1 0 Transcription factor PAP1 MARCKS PF02063.12 EWC44477.1 - 6.7 6.4 8.7 9.6 5.9 6.0 1.1 1 0 0 1 1 1 0 MARCKS family Med22 PF06179.7 EWC44479.1 - 1.3e-18 67.0 1.5 1.5e-18 66.7 1.0 1.1 1 0 0 1 1 1 1 Surfeit locus protein 5 subunit 22 of Mediator complex Y_phosphatase2 PF03162.8 EWC44479.1 - 0.098 12.0 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family Pinin_SDK_memA PF04696.8 EWC44480.1 - 2.7e-16 59.3 10.9 2.7e-16 59.3 7.5 1.9 2 1 0 2 2 2 1 pinin/SDK/memA/ protein conserved region tRNA-synt_2 PF00152.15 EWC44481.1 - 3.5e-73 246.2 0.0 5.8e-73 245.5 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 EWC44481.1 - 4e-11 42.6 0.0 7.7e-11 41.6 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain Cwf_Cwc_15 PF04889.7 EWC44482.1 - 2.3e-86 289.5 21.3 2.5e-86 289.3 14.8 1.0 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein DUF4519 PF15012.1 EWC44482.1 - 0.93 9.4 4.7 2.7 7.9 3.2 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4519) Adaptin_binding PF10199.4 EWC44482.1 - 1.3 9.3 17.6 2 8.7 12.2 1.3 1 0 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 DUF2890 PF11081.3 EWC44482.1 - 8.3 6.4 21.7 13 5.7 14.3 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2890) PHF5 PF03660.9 EWC44483.1 - 2.2e-52 175.6 9.2 2.5e-52 175.4 6.4 1.0 1 0 0 1 1 1 1 PHF5-like protein DZR PF12773.2 EWC44483.1 - 0.82 9.5 15.0 0.62 9.9 6.1 2.8 1 1 1 2 2 2 0 Double zinc ribbon Prok-RING_1 PF14446.1 EWC44483.1 - 1.2 8.9 15.2 3.1 7.6 0.4 3.0 3 1 0 3 3 3 0 Prokaryotic RING finger family 1 RNase_PH PF01138.16 EWC44484.1 - 5e-21 75.3 0.0 1.1e-20 74.2 0.0 1.5 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.10 EWC44484.1 - 1.1e-12 47.6 0.1 2e-12 46.8 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Abhydrolase_3 PF07859.8 EWC44485.1 - 4.8e-38 130.8 0.0 9.2e-38 129.9 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.23 EWC44485.1 - 2.9e-06 26.2 0.0 5e-06 25.5 0.0 1.2 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_5 PF12695.2 EWC44485.1 - 0.0037 17.0 0.0 0.0051 16.5 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Chlorophyllase PF07224.6 EWC44485.1 - 0.057 12.2 0.0 0.09 11.5 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase Chlorophyllase2 PF12740.2 EWC44485.1 - 0.086 11.7 0.0 0.13 11.0 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme Peptidase_S9 PF00326.16 EWC44485.1 - 0.12 11.5 0.0 1.5 7.9 0.0 2.1 2 0 0 2 2 2 0 Prolyl oligopeptidase family DUF2694 PF10904.3 EWC44487.1 - 0.08 12.9 0.0 0.15 12.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2694) RRM_6 PF14259.1 EWC44489.1 - 6.1e-38 128.6 0.0 1.5e-09 37.6 0.0 4.3 4 0 0 4 4 4 4 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 EWC44489.1 - 3e-37 126.0 0.1 4.2e-12 45.5 0.1 4.5 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EWC44489.1 - 2.2e-18 65.8 0.0 0.00042 20.1 0.1 4.6 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM PF10378.4 EWC44489.1 - 1.8e-06 27.4 3.1 1.8e-06 27.4 2.2 3.2 3 0 0 3 3 3 1 Putative RRM domain RRM_3 PF08777.6 EWC44489.1 - 0.00012 21.8 0.0 0.025 14.4 0.1 2.5 2 0 0 2 2 2 1 RNA binding motif RNA_bind PF08675.6 EWC44489.1 - 0.041 13.8 0.0 0.26 11.2 0.0 2.4 2 0 0 2 2 2 0 RNA binding domain Spo7_2_N PF15407.1 EWC44489.1 - 0.13 11.7 0.0 4.6 6.7 0.0 2.7 2 0 0 2 2 2 0 Sporulation protein family 7 CTK3 PF12243.3 EWC44490.1 - 3.6e-43 146.5 1.3 5.3e-43 145.9 0.9 1.2 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 CTK3_C PF12350.3 EWC44490.1 - 5.1e-13 48.8 2.7 5.1e-13 48.8 1.9 2.5 2 1 0 2 2 2 1 CTD kinase subunit gamma CTK3 C-terminus MAM33 PF02330.11 EWC44490.1 - 0.004 16.9 1.5 0.016 14.9 0.0 2.2 2 0 0 2 2 2 1 Mitochondrial glycoprotein Zip PF02535.17 EWC44490.1 - 0.072 12.0 0.1 0.12 11.3 0.0 1.3 1 1 0 1 1 1 0 ZIP Zinc transporter CENP-H PF05837.7 EWC44490.1 - 0.2 11.8 2.4 0.18 11.9 0.4 1.9 2 0 0 2 2 2 0 Centromere protein H (CENP-H) Acetyltransf_2 PF00797.12 EWC44491.1 - 9.9e-37 126.7 0.0 1.8e-36 125.9 0.0 1.4 1 1 0 1 1 1 1 N-acetyltransferase Abhydrolase_6 PF12697.2 EWC44492.1 - 1.8e-32 113.1 0.4 2.5e-32 112.6 0.3 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EWC44492.1 - 9.5e-18 64.5 0.1 3.4e-16 59.5 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EWC44492.1 - 9.7e-08 31.8 0.0 4.6e-07 29.6 0.0 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 EWC44492.1 - 0.0001 22.0 0.0 0.00027 20.7 0.0 1.7 1 0 0 1 1 1 1 Putative lysophospholipase DUF1057 PF06342.7 EWC44492.1 - 0.028 13.2 0.0 0.045 12.5 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) Tcf25 PF04910.9 EWC44492.1 - 0.11 11.4 0.0 0.14 11.0 0.0 1.1 1 0 0 1 1 1 0 Transcriptional repressor TCF25 WD40 PF00400.27 EWC44493.1 - 2.4e-24 84.2 23.5 2.1e-08 33.7 0.0 9.6 10 0 0 10 10 10 6 WD domain, G-beta repeat NACHT PF05729.7 EWC44493.1 - 7.6e-22 77.7 0.1 1.4e-21 76.8 0.0 1.4 1 0 0 1 1 1 1 NACHT domain Gmad1 PF10647.4 EWC44493.1 - 0.00016 21.1 0.0 0.51 9.6 0.0 3.6 4 0 0 4 4 4 2 Lipoprotein LpqB beta-propeller domain AAA_19 PF13245.1 EWC44493.1 - 0.0064 16.2 0.0 0.02 14.6 0.0 1.8 1 0 0 1 1 1 1 Part of AAA domain Nup160 PF11715.3 EWC44493.1 - 0.03 12.4 7.0 2 6.4 0.0 4.3 4 1 0 5 5 5 0 Nucleoporin Nup120/160 PNP_UDP_1 PF01048.15 EWC44494.1 - 2e-19 69.5 0.0 4.7e-19 68.2 0.0 1.6 1 1 0 1 1 1 1 Phosphorylase superfamily DUF348 PF03990.9 EWC44494.1 - 0.11 12.0 0.1 0.23 11.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF348) Saccharop_dh PF03435.13 EWC44495.1 - 2e-15 56.6 0.0 2.7e-15 56.2 0.0 1.1 1 0 0 1 1 1 1 Saccharopine dehydrogenase PRCC PF10253.4 EWC44496.1 - 1.4e-36 126.8 0.1 1.4e-36 126.8 0.0 2.2 2 1 0 2 2 2 1 Mitotic checkpoint regulator, MAD2B-interacting P5CR_dimer PF14748.1 EWC44497.1 - 9.9e-35 118.7 1.1 9.9e-35 118.7 0.8 1.6 2 0 0 2 2 2 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.12 EWC44497.1 - 1.6e-11 44.5 0.9 5.6e-07 29.8 0.0 2.5 2 0 0 2 2 2 2 NADP oxidoreductase coenzyme F420-dependent DHFR_1 PF00186.14 EWC44498.1 - 8.7e-17 61.1 0.0 4e-16 59.0 0.0 1.9 1 1 0 1 1 1 1 Dihydrofolate reductase RNA_POL_M_15KD PF02150.11 EWC44500.1 - 8.6e-12 44.5 3.5 8.6e-12 44.5 2.4 2.2 3 0 0 3 3 3 1 RNA polymerases M/15 Kd subunit TFIIS_C PF01096.13 EWC44500.1 - 1.2e-05 24.8 0.4 1.2e-05 24.8 0.3 3.0 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) SR-25 PF10500.4 EWC44500.1 - 0.0094 15.4 1.3 0.0094 15.4 0.9 1.9 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein Lar_restr_allev PF14354.1 EWC44500.1 - 0.026 14.8 0.9 0.35 11.1 0.0 2.4 2 0 0 2 2 2 0 Restriction alleviation protein Lar DZR PF12773.2 EWC44500.1 - 0.12 12.2 5.0 0.95 9.3 1.3 2.4 2 0 0 2 2 2 0 Double zinc ribbon GFA PF04828.9 EWC44500.1 - 0.13 12.1 5.9 0.71 9.8 0.1 2.4 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme Zn_Tnp_IS1595 PF12760.2 EWC44500.1 - 0.37 10.6 4.8 6.2 6.7 0.1 2.4 2 0 0 2 2 2 0 Transposase zinc-ribbon domain Ribosomal_L12 PF00542.14 EWC44501.1 - 2.7e-20 72.1 6.3 2.7e-20 72.1 4.4 1.9 2 0 0 2 2 2 1 Ribosomal protein L7/L12 C-terminal domain SET PF00856.23 EWC44502.1 - 1.6e-09 38.3 0.1 1.6e-09 38.3 0.1 3.0 2 2 1 3 3 3 1 SET domain DUF4620 PF15399.1 EWC44502.1 - 0.068 13.2 0.2 0.13 12.3 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4620) Herpes_U34 PF04541.8 EWC44502.1 - 0.2 10.5 3.1 0.4 9.5 1.9 1.6 1 1 0 1 1 1 0 Herpesvirus virion protein U34 Sec7 PF01369.15 EWC44503.1 - 2.4e-40 138.2 0.3 4.5e-40 137.3 0.2 1.4 1 0 0 1 1 1 1 Sec7 domain PH PF00169.24 EWC44503.1 - 3.3e-05 24.0 0.2 0.00017 21.7 0.1 2.3 2 0 0 2 2 2 1 PH domain PH_9 PF15410.1 EWC44503.1 - 0.00011 22.3 0.1 0.00031 20.9 0.1 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain DUF1510 PF07423.6 EWC44503.1 - 6.4 6.0 21.5 16 4.7 14.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Peptidase_M14 PF00246.19 EWC44504.1 - 1.3e-66 225.0 0.0 2.3e-66 224.2 0.0 1.3 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.11 EWC44504.1 - 0.071 12.7 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Carboxypeptidase activation peptide Ribosomal_L14 PF00238.14 EWC44505.1 - 1.6e-46 156.9 2.1 1.8e-46 156.8 1.5 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e Pkinase PF00069.20 EWC44506.1 - 3e-68 229.7 0.0 3.7e-68 229.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC44506.1 - 7.7e-37 126.7 0.0 1e-36 126.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EWC44506.1 - 1.2e-05 24.4 0.0 2.1e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 EWC44506.1 - 0.098 12.3 0.0 0.28 10.8 0.0 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family DUF1777 PF08648.7 EWC44507.1 - 0.85 9.3 33.4 0.45 10.2 5.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1777) CLASP_N PF12348.3 EWC44508.1 - 6.8e-05 22.3 2.0 0.0028 17.0 0.3 2.9 3 0 0 3 3 3 1 CLASP N terminal HEAT_2 PF13646.1 EWC44508.1 - 0.041 14.1 0.6 0.041 14.1 0.4 4.5 6 1 0 6 6 6 0 HEAT repeats ParcG PF10274.4 EWC44508.1 - 0.31 10.9 2.3 6 6.7 0.0 3.3 4 0 0 4 4 4 0 Parkin co-regulated protein HEAT PF02985.17 EWC44508.1 - 0.58 10.3 7.0 0.42 10.8 0.1 4.5 5 0 0 5 5 5 0 HEAT repeat Ecl1 PF12855.2 EWC44509.1 - 1.4e-12 46.6 0.1 2.3e-12 45.9 0.1 1.3 1 0 0 1 1 1 1 Life-span regulatory factor zf-MYND PF01753.13 EWC44509.1 - 0.00028 20.6 0.7 0.00055 19.7 0.5 1.4 1 0 0 1 1 1 1 MYND finger YL1 PF05764.8 EWC44510.1 - 4.3e-47 160.7 34.1 7.1e-47 160.0 23.7 1.3 1 0 0 1 1 1 1 YL1 nuclear protein YL1_C PF08265.6 EWC44510.1 - 4e-08 32.6 0.1 6.3e-08 32.0 0.1 1.3 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain DEK_C PF08766.6 EWC44510.1 - 0.0062 16.2 0.0 0.012 15.4 0.0 1.4 1 0 0 1 1 1 1 DEK C terminal domain PUF PF00806.14 EWC44511.1 - 9.6e-30 100.3 0.0 0.0001 21.5 0.0 5.9 6 0 0 6 6 6 5 Pumilio-family RNA binding repeat RRM_1 PF00076.17 EWC44511.1 - 1.1e-10 41.0 0.0 2.4e-10 39.8 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EWC44511.1 - 5.2e-06 26.3 0.0 1.2e-05 25.1 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EWC44511.1 - 6.2e-05 22.7 0.0 0.00013 21.7 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2811 PF10929.3 EWC44511.1 - 0.09 12.7 0.1 0.21 11.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2811) Zip PF02535.17 EWC44511.1 - 0.35 9.8 3.2 0.64 8.9 2.2 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter PAT1 PF09770.4 EWC44511.1 - 1.4 7.0 19.8 2.7 6.1 13.7 1.4 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 NicO PF03824.11 EWC44512.1 - 8.8e-58 195.8 16.1 1.4e-57 195.1 11.2 1.3 1 0 0 1 1 1 1 High-affinity nickel-transport protein MBOAT PF03062.14 EWC44513.1 - 2.4e-20 72.9 14.1 6.4e-20 71.5 9.8 1.7 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.1 EWC44513.1 - 0.00023 21.1 1.4 0.00082 19.3 1.0 1.9 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family mRNA_cap_enzyme PF01331.14 EWC44514.1 - 1.3e-53 181.5 0.9 1.7e-53 181.1 0.6 1.1 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.10 EWC44514.1 - 5.4e-22 78.1 0.2 1.2e-21 76.9 0.1 1.6 1 1 0 1 1 1 1 mRNA capping enzyme, C-terminal domain DNA_ligase_A_M PF01068.16 EWC44514.1 - 1.8e-09 37.2 0.6 1.1e-07 31.4 0.4 2.5 1 1 0 1 1 1 1 ATP dependent DNA ligase domain RNA_pol_3_Rpc31 PF11705.3 EWC44515.1 - 2.9e-18 66.6 63.4 5.1e-16 59.3 44.0 2.8 1 1 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 SGT1 PF07093.6 EWC44515.1 - 0.53 8.6 10.6 0.54 8.5 7.3 1.1 1 0 0 1 1 1 0 SGT1 protein DUF2201_N PF13203.1 EWC44515.1 - 2.8 7.0 5.4 3.7 6.6 3.7 1.2 1 0 0 1 1 1 0 Putative metallopeptidase domain TFIIA PF03153.8 EWC44515.1 - 3 7.6 15.9 4.1 7.1 11.0 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF3445 PF11927.3 EWC44516.1 - 1.4e-64 217.8 0.0 1.8e-64 217.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3445) F-box PF00646.28 EWC44518.1 - 0.00018 21.0 0.1 0.00037 20.0 0.1 1.5 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 EWC44518.1 - 0.012 15.2 0.2 0.024 14.3 0.1 1.5 1 0 0 1 1 1 0 F-box-like YbjQ_1 PF01906.12 EWC44519.1 - 8.3e-28 96.8 0.2 1.1e-27 96.5 0.2 1.1 1 0 0 1 1 1 1 Putative heavy-metal-binding ECH PF00378.15 EWC44521.1 - 4.2e-21 75.1 0.0 5.4e-21 74.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family Peptidase_S49 PF01343.13 EWC44521.1 - 0.14 11.9 0.0 4.7 6.9 0.0 2.2 2 0 0 2 2 2 0 Peptidase family S49 Tho2 PF11262.3 EWC44524.1 - 2.8e-76 256.4 0.7 4.9e-76 255.6 0.5 1.4 1 0 0 1 1 1 1 Transcription factor/nuclear export subunit protein 2 Thoc2 PF11732.3 EWC44524.1 - 7.9e-26 89.6 0.0 2.3e-25 88.1 0.0 1.9 1 0 0 1 1 1 1 Transcription- and export-related complex subunit Autophagy_N PF03986.8 EWC44525.1 - 4.5e-43 146.5 0.1 4.5e-43 146.5 0.1 2.1 2 0 0 2 2 2 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_act_C PF03987.10 EWC44525.1 - 1.4e-18 66.8 0.1 2.7e-18 65.9 0.1 1.5 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Autophagy_Cterm PF10381.4 EWC44525.1 - 5.6e-15 54.1 0.3 1.1e-14 53.2 0.2 1.5 1 0 0 1 1 1 1 Autophagocytosis associated protein C-terminal GRAM PF02893.15 EWC44526.1 - 3.5e-17 61.6 0.0 6.7e-17 60.7 0.0 1.5 1 0 0 1 1 1 1 GRAM domain DivIC PF04977.10 EWC44527.1 - 0.0076 15.7 1.0 0.0076 15.7 0.7 2.3 3 0 0 3 3 3 1 Septum formation initiator DUF972 PF06156.8 EWC44527.1 - 0.026 14.8 0.4 0.026 14.8 0.3 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF972) DUF904 PF06005.7 EWC44527.1 - 1.2 9.4 9.6 1.1 9.5 0.3 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF904) Methyltransf_23 PF13489.1 EWC44528.1 - 1.9e-20 73.1 0.0 2.6e-20 72.7 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EWC44528.1 - 2.3e-15 56.8 0.0 4.4e-15 55.9 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EWC44528.1 - 1.1e-14 54.9 0.0 2.4e-14 53.8 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 EWC44528.1 - 2.8e-13 50.1 0.0 9.4e-13 48.4 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EWC44528.1 - 3.4e-13 49.4 0.0 9e-07 28.5 0.0 2.1 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_26 PF13659.1 EWC44528.1 - 6.9e-11 42.2 0.1 1.4e-10 41.2 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EWC44528.1 - 9.7e-06 25.0 0.0 0.003 16.9 0.0 2.1 2 0 0 2 2 2 2 Methyltransferase small domain Methyltransf_25 PF13649.1 EWC44528.1 - 5.2e-05 23.5 0.0 9.6e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 EWC44528.1 - 0.0002 20.6 0.0 0.00068 18.8 0.0 1.7 1 1 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_16 PF10294.4 EWC44528.1 - 0.003 17.0 0.0 0.0065 15.9 0.0 1.6 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_24 PF13578.1 EWC44528.1 - 0.0038 18.0 0.0 0.0059 17.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain DREV PF05219.7 EWC44528.1 - 0.0045 15.8 0.0 0.0071 15.2 0.0 1.2 1 0 0 1 1 1 1 DREV methyltransferase Methyltransf_PK PF05891.7 EWC44528.1 - 0.0055 16.0 0.0 0.022 14.0 0.0 1.8 1 1 0 1 1 1 1 AdoMet dependent proline di-methyltransferase RrnaAD PF00398.15 EWC44528.1 - 0.014 14.3 0.0 0.022 13.8 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase TehB PF03848.9 EWC44528.1 - 0.049 12.7 0.0 1.5 7.9 0.0 2.5 3 0 0 3 3 3 0 Tellurite resistance protein TehB CS PF04969.11 EWC44529.1 - 4.1e-16 59.2 0.0 1.1e-15 57.9 0.0 1.7 1 0 0 1 1 1 1 CS domain Auxin_repressed PF05564.7 EWC44531.1 - 0.54 10.8 7.2 0.44 11.1 3.3 2.1 1 1 1 2 2 2 0 Dormancy/auxin associated protein Img2 PF05046.9 EWC44532.1 - 4.4e-18 65.2 0.0 5.9e-18 64.8 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) AMP-binding PF00501.23 EWC44533.1 - 2.4e-68 230.4 0.0 3.9e-68 229.7 0.0 1.3 1 1 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 EWC44533.1 - 1.1e-12 48.7 0.1 2.6e-12 47.5 0.1 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain WD40 PF00400.27 EWC44534.1 - 1.1e-34 116.9 9.0 2.2e-05 24.1 0.0 7.8 8 0 0 8 8 8 6 WD domain, G-beta repeat Apc4_WD40 PF12894.2 EWC44534.1 - 0.00014 21.2 0.0 0.2 11.2 0.0 3.1 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain SNase PF00565.12 EWC44535.1 - 6.5e-65 216.1 3.6 5.3e-23 81.3 0.0 5.7 6 0 0 6 6 6 5 Staphylococcal nuclease homologue TUDOR PF00567.19 EWC44535.1 - 6.8e-26 90.4 0.0 5.5e-25 87.5 0.0 2.1 2 0 0 2 2 2 1 Tudor domain SMN PF06003.7 EWC44535.1 - 2e-06 27.0 0.0 4.1e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 Survival motor neuron protein (SMN) Gp49 PF05973.9 EWC44535.1 - 0.051 13.5 0.0 0.19 11.7 0.0 2.0 1 0 0 1 1 1 0 Phage derived protein Gp49-like (DUF891) DUF3297 PF11730.3 EWC44535.1 - 0.09 12.4 0.1 0.31 10.7 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3297) Recep_L_domain PF01030.19 EWC44536.1 - 5.8e-12 45.5 1.7 0.0013 18.7 0.2 4.6 1 1 3 4 4 4 4 Receptor L domain LRR_5 PF13306.1 EWC44536.1 - 0.00023 20.8 0.6 0.016 14.9 0.4 2.9 3 0 0 3 3 3 1 Leucine rich repeats (6 copies) DUF1752 PF08550.5 EWC44537.1 - 6.6e-11 41.5 0.5 1.7e-10 40.2 0.4 1.7 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) DUF1620 PF07774.8 EWC44538.1 - 4.6e-65 218.9 0.0 7.6e-65 218.1 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1620) PQQ_2 PF13360.1 EWC44538.1 - 5.3e-17 62.0 7.3 1.9e-11 43.8 0.6 3.4 4 0 0 4 4 4 2 PQQ-like domain PQQ PF01011.16 EWC44538.1 - 1.7e-05 24.0 0.4 1.4 8.5 0.0 5.6 6 0 0 6 6 6 2 PQQ enzyme repeat IMS PF00817.15 EWC44539.1 - 7.2e-47 158.9 0.0 1.1e-46 158.2 0.0 1.3 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.3 EWC44539.1 - 6.7e-11 42.2 0.0 1.6e-10 41.0 0.0 1.6 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.3 EWC44539.1 - 0.025 14.5 0.0 0.07 13.2 0.0 1.8 1 0 0 1 1 1 0 IMS family HHH motif AT_hook PF02178.14 EWC44539.1 - 0.064 12.9 5.2 0.24 11.1 3.6 2.1 1 0 0 1 1 1 0 AT hook motif DDOST_48kD PF03345.9 EWC44541.1 - 3.3e-131 437.7 0.0 3.7e-131 437.5 0.0 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta tify PF06200.9 EWC44542.1 - 0.13 11.5 0.0 0.28 10.4 0.0 1.5 1 0 0 1 1 1 0 tify domain Zip PF02535.17 EWC44542.1 - 0.21 10.5 7.7 0.34 9.8 5.3 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter PVL_ORF50 PF07768.6 EWC44542.1 - 2.3 8.2 6.9 0.64 10.0 0.2 2.7 3 0 0 3 3 3 0 PVL ORF-50-like family SelP_N PF04592.9 EWC44542.1 - 4.1 6.7 15.3 4.3 6.6 5.3 2.3 2 0 0 2 2 2 0 Selenoprotein P, N terminal region 2OG-FeII_Oxy_2 PF13532.1 EWC44543.1 - 6.3e-18 65.3 0.0 1.1e-17 64.4 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily SAD_SRA PF02182.12 EWC44543.1 - 3.8e-05 23.0 0.0 7e-05 22.1 0.0 1.4 1 0 0 1 1 1 1 SAD/SRA domain F-box-like PF12937.2 EWC44544.1 - 0.0013 18.4 0.2 0.0031 17.2 0.2 1.7 1 0 0 1 1 1 1 F-box-like Ank_2 PF12796.2 EWC44545.1 - 4.6e-121 395.4 17.9 1.3e-21 76.6 0.2 8.0 2 2 7 9 9 9 9 Ankyrin repeats (3 copies) Ank PF00023.25 EWC44545.1 - 2.1e-100 323.8 21.7 5.7e-10 38.5 0.0 15.5 15 1 0 15 15 15 14 Ankyrin repeat Ank_3 PF13606.1 EWC44545.1 - 7.7e-80 254.7 3.9 3.6e-07 29.8 0.0 15.1 15 0 0 15 15 15 13 Ankyrin repeat Ank_4 PF13637.1 EWC44545.1 - 2.5e-77 253.9 2.6 2.1e-13 50.3 0.0 9.6 6 3 4 10 10 10 10 Ankyrin repeats (many copies) Ank_5 PF13857.1 EWC44545.1 - 5.2e-67 220.3 15.8 1.1e-08 35.0 0.0 12.8 4 3 9 13 13 13 13 Ankyrin repeats (many copies) Rbsn PF11464.3 EWC44545.1 - 0.034 13.7 0.0 45 3.7 0.0 4.8 5 0 0 5 5 5 0 Rabenosyn Rab binding domain AAA PF00004.24 EWC44546.1 - 1e-33 116.3 0.0 3.5e-33 114.5 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 EWC44546.1 - 2.9e-06 27.3 0.2 0.00037 20.5 0.1 3.1 1 1 0 1 1 1 1 AAA ATPase domain DUF815 PF05673.8 EWC44546.1 - 1.5e-05 24.0 0.0 2.8e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_5 PF07728.9 EWC44546.1 - 5.2e-05 22.9 0.0 0.0002 21.1 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 EWC44546.1 - 5.4e-05 23.3 0.2 0.003 17.7 0.1 2.6 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.1 EWC44546.1 - 0.00014 21.7 0.1 0.0012 18.7 0.1 2.5 2 1 0 2 2 2 1 AAA domain AAA_11 PF13086.1 EWC44546.1 - 0.00057 19.5 0.0 0.0011 18.6 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.1 EWC44546.1 - 0.00066 19.5 0.0 0.0013 18.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.17 EWC44546.1 - 0.0015 18.6 0.0 0.004 17.3 0.0 1.8 1 1 0 1 1 1 1 RNA helicase AAA_25 PF13481.1 EWC44546.1 - 0.002 17.5 0.5 0.027 13.8 0.3 2.3 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 EWC44546.1 - 0.0026 17.4 0.5 0.0092 15.7 0.1 2.0 2 0 0 2 2 2 1 Part of AAA domain AAA_17 PF13207.1 EWC44546.1 - 0.0054 17.5 0.0 0.014 16.1 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 EWC44546.1 - 0.0058 16.9 0.0 0.25 11.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.1 EWC44546.1 - 0.0084 15.7 0.0 0.018 14.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.12 EWC44546.1 - 0.0089 15.4 0.1 0.016 14.6 0.1 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein NTPase_1 PF03266.10 EWC44546.1 - 0.009 15.7 0.0 0.025 14.3 0.0 1.7 1 1 0 1 1 1 1 NTPase AAA_24 PF13479.1 EWC44546.1 - 0.026 14.0 0.5 0.051 13.1 0.3 1.4 1 0 0 1 1 1 0 AAA domain Arch_ATPase PF01637.13 EWC44546.1 - 0.031 13.9 0.0 0.093 12.4 0.0 1.8 1 1 0 1 1 1 0 Archaeal ATPase RuvB_N PF05496.7 EWC44546.1 - 0.033 13.2 0.0 0.062 12.3 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus UPF0079 PF02367.12 EWC44546.1 - 0.039 13.5 0.1 0.071 12.7 0.1 1.3 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 NACHT PF05729.7 EWC44546.1 - 0.071 12.7 0.0 0.79 9.3 0.0 2.3 2 0 0 2 2 2 0 NACHT domain MCM PF00493.18 EWC44546.1 - 0.1 11.3 0.0 0.19 10.4 0.0 1.3 1 0 0 1 1 1 0 MCM2/3/5 family KaiC PF06745.8 EWC44546.1 - 0.12 11.4 0.1 0.25 10.4 0.0 1.5 1 0 0 1 1 1 0 KaiC AAA PF00004.24 EWC44547.1 - 3.1e-33 114.7 0.0 6.5e-33 113.7 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) TIP49 PF06068.8 EWC44547.1 - 4.8e-06 25.5 0.0 9.7e-06 24.5 0.0 1.4 1 0 0 1 1 1 1 TIP49 C-terminus AAA_22 PF13401.1 EWC44547.1 - 2e-05 24.7 0.0 0.0035 17.4 0.0 2.9 1 1 1 2 2 2 1 AAA domain AAA_17 PF13207.1 EWC44547.1 - 5.2e-05 24.0 0.0 0.0002 22.1 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 EWC44547.1 - 7.3e-05 22.8 0.2 0.037 13.9 0.0 2.7 1 1 1 2 2 2 1 AAA ATPase domain IstB_IS21 PF01695.12 EWC44547.1 - 0.00012 21.5 0.0 0.00024 20.5 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein RuvB_N PF05496.7 EWC44547.1 - 0.00024 20.2 0.0 0.00047 19.2 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_33 PF13671.1 EWC44547.1 - 0.0012 18.7 0.0 0.0035 17.2 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 EWC44547.1 - 0.0017 18.6 0.0 0.0036 17.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.9 EWC44547.1 - 0.0018 17.9 0.0 0.018 14.7 0.0 2.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_19 PF13245.1 EWC44547.1 - 0.0037 16.9 0.3 0.014 15.1 0.0 2.1 2 0 0 2 2 1 1 Part of AAA domain AAA_14 PF13173.1 EWC44547.1 - 0.0065 16.3 0.0 0.02 14.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_2 PF07724.9 EWC44547.1 - 0.0068 16.3 0.0 0.014 15.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.8 EWC44547.1 - 0.0092 14.9 0.0 0.019 13.8 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_28 PF13521.1 EWC44547.1 - 0.012 15.5 0.0 0.028 14.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 EWC44547.1 - 0.014 15.5 0.0 0.048 13.8 0.0 2.0 2 0 0 2 2 1 0 RNA helicase Zeta_toxin PF06414.7 EWC44547.1 - 0.029 13.4 0.0 0.06 12.4 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_10 PF12846.2 EWC44547.1 - 0.03 13.7 0.0 5.2 6.4 0.0 2.6 2 1 0 2 2 2 0 AAA-like domain Mg_chelatase PF01078.16 EWC44547.1 - 0.038 13.1 0.1 1 8.4 0.0 2.3 1 1 0 2 2 2 0 Magnesium chelatase, subunit ChlI UPF0079 PF02367.12 EWC44547.1 - 0.039 13.5 0.0 0.083 12.5 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 AAA_11 PF13086.1 EWC44547.1 - 0.044 13.3 0.0 0.087 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain Bac_DnaA PF00308.13 EWC44547.1 - 0.065 12.8 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 Bacterial dnaA protein Viral_helicase1 PF01443.13 EWC44547.1 - 0.08 12.4 0.0 0.15 11.5 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Sigma54_activat PF00158.21 EWC44547.1 - 0.18 11.3 0.0 1.4 8.3 0.0 2.4 1 1 0 1 1 1 0 Sigma-54 interaction domain Fib_alpha PF08702.5 EWC44548.1 - 0.056 13.5 0.0 0.96 9.5 0.0 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Pyr_redox_2 PF07992.9 EWC44549.1 - 2.2e-13 50.5 0.0 4.6e-13 49.5 0.0 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 EWC44549.1 - 1e-08 35.4 0.8 1.9e-06 28.2 0.2 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 EWC44549.1 - 5e-08 32.2 3.5 0.018 13.9 0.0 4.0 3 1 1 4 4 4 3 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 EWC44549.1 - 1.1e-06 28.9 0.0 0.0001 22.4 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 EWC44549.1 - 0.00019 21.2 0.1 0.57 9.9 0.0 3.7 4 0 0 4 4 4 1 FAD-NAD(P)-binding Thi4 PF01946.12 EWC44549.1 - 0.0016 17.6 1.3 0.33 10.0 0.1 2.3 2 0 0 2 2 2 2 Thi4 family K_oxygenase PF13434.1 EWC44549.1 - 0.024 13.5 0.1 0.061 12.2 0.0 1.6 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_3 PF01494.14 EWC44549.1 - 0.12 11.4 0.6 1.9 7.4 0.1 2.1 2 0 0 2 2 2 0 FAD binding domain Lycopene_cycl PF05834.7 EWC44549.1 - 0.13 11.1 0.2 0.51 9.2 0.0 1.9 2 0 0 2 2 2 0 Lycopene cyclase protein NAD_binding_8 PF13450.1 EWC44549.1 - 0.57 10.2 3.7 1.2 9.2 0.1 2.8 3 0 0 3 3 3 0 NAD(P)-binding Rossmann-like domain Trp_halogenase PF04820.9 EWC44549.1 - 1.1 7.7 3.2 3.3 6.2 0.5 2.2 2 1 0 2 2 2 0 Tryptophan halogenase Fungal_trans PF04082.13 EWC44550.1 - 1.3e-12 47.2 0.0 4.2e-12 45.4 0.0 1.7 1 1 0 2 2 2 1 Fungal specific transcription factor domain MogR_DNAbind PF12181.3 EWC44550.1 - 0.017 14.8 0.1 0.032 14.0 0.0 1.3 1 0 0 1 1 1 0 DNA binding domain of the motility gene repressor (MogR) zf-DHHC PF01529.15 EWC44551.1 - 5.3e-30 104.0 0.0 7.7e-30 103.5 0.0 1.2 1 0 0 1 1 1 1 DHHC palmitoyltransferase COX4_pro_2 PF07835.7 EWC44551.1 - 0.035 14.0 1.8 0.069 13.1 1.2 1.5 1 0 0 1 1 1 0 Bacterial aa3 type cytochrome c oxidase subunit IV OTT_1508_deam PF14441.1 EWC44552.1 - 0.0019 18.0 0.0 0.0035 17.1 0.0 1.4 1 0 0 1 1 1 1 OTT_1508-like deaminase CNH PF00780.17 EWC44553.1 - 2.4e-82 276.4 0.0 6.5e-82 275.0 0.0 1.7 2 0 0 2 2 2 1 CNH domain PH_5 PF15405.1 EWC44553.1 - 3e-45 153.4 0.0 3e-45 153.4 0.0 2.3 2 1 0 2 2 2 1 Pleckstrin homology domain RhoGEF PF00621.15 EWC44553.1 - 5.4e-39 133.9 0.1 8.9e-39 133.2 0.0 1.4 1 0 0 1 1 1 1 RhoGEF domain DEP PF00610.16 EWC44553.1 - 1.4e-12 47.1 0.0 2.7e-12 46.2 0.0 1.5 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) ATP-synt_C PF00137.16 EWC44554.1 - 8.5e-27 92.8 29.8 3.4e-16 58.9 6.0 2.1 2 0 0 2 2 2 2 ATP synthase subunit C ABA_GPCR PF12430.3 EWC44554.1 - 0.27 10.3 1.8 3.1 6.8 0.1 2.1 2 0 0 2 2 2 0 Abscisic acid G-protein coupled receptor 2TM PF13239.1 EWC44554.1 - 0.47 10.5 2.1 1.8 8.6 0.1 2.4 1 1 0 2 2 2 0 2TM domain Pkinase PF00069.20 EWC44555.1 - 2.4e-62 210.4 0.0 3e-62 210.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC44555.1 - 2.3e-33 115.3 0.0 4.1e-33 114.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EWC44555.1 - 3.4e-07 29.5 0.0 4.9e-07 28.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 EWC44555.1 - 7.9e-05 21.8 0.0 0.00054 19.0 0.0 1.9 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 EWC44555.1 - 0.0053 16.5 0.0 0.016 14.9 0.0 1.6 1 1 1 2 2 2 1 Phosphotransferase enzyme family Rad21_Rec8 PF04824.11 EWC44555.1 - 0.063 12.4 0.0 0.14 11.3 0.0 1.4 1 0 0 1 1 1 0 Conserved region of Rad21 / Rec8 like protein AMP-binding PF00501.23 EWC44556.1 - 5.9e-89 298.3 0.0 7.9e-89 297.9 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 EWC44556.1 - 1.4e-18 67.5 0.1 4.1e-18 66.0 0.0 1.9 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain CRT10 PF08728.5 EWC44557.1 - 2.8e-23 81.8 0.0 1.5e-18 66.2 0.0 2.3 2 0 0 2 2 2 2 CRT10 FAD_binding_6 PF00970.19 EWC44558.1 - 5.5e-07 29.6 0.0 2e-06 27.8 0.0 2.0 2 1 0 2 2 2 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.16 EWC44558.1 - 6.8e-05 23.3 0.0 0.0001 22.8 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.7 EWC44558.1 - 0.096 12.5 0.0 0.22 11.4 0.0 1.6 1 1 1 2 2 2 0 Ferric reductase NAD binding domain Chorismate_bind PF00425.13 EWC44560.1 - 6.4e-63 212.4 0.0 2.8e-62 210.3 0.0 2.1 1 1 0 1 1 1 1 chorismate binding enzyme GATase PF00117.23 EWC44560.1 - 7e-32 110.4 0.0 1.1e-31 109.7 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Anth_synt_I_N PF04715.8 EWC44560.1 - 7.5e-16 58.4 0.0 1.5e-15 57.4 0.0 1.5 1 0 0 1 1 1 1 Anthranilate synthase component I, N terminal region Peptidase_C26 PF07722.8 EWC44560.1 - 3.7e-08 33.0 0.0 7.3e-08 32.1 0.0 1.5 1 0 0 1 1 1 1 Peptidase C26 GPP34 PF05719.6 EWC44560.1 - 0.021 14.8 1.3 0.077 13.0 0.1 2.1 2 0 0 2 2 2 0 Golgi phosphoprotein 3 (GPP34) Vps55 PF04133.9 EWC44561.1 - 4.7e-43 145.7 6.9 5.2e-43 145.6 4.8 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting 55 DUF2781 PF10914.3 EWC44561.1 - 0.014 15.2 1.9 0.022 14.5 1.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2781) Proteasome PF00227.21 EWC44562.1 - 2.6e-49 167.1 0.0 3.2e-49 166.8 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 EWC44562.1 - 4.9e-12 44.9 0.1 8.7e-12 44.1 0.1 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature TRAPPC9-Trs120 PF08626.6 EWC44563.1 - 4e-146 488.2 0.0 1e-145 486.8 0.0 1.6 1 1 0 1 1 1 1 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit DUF3684 PF12449.3 EWC44564.1 - 0 1130.3 0.0 0 1129.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3684) HATPase_c PF02518.21 EWC44564.1 - 0.00021 20.9 0.0 0.00053 19.6 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.1 EWC44564.1 - 0.0062 16.1 0.0 0.025 14.2 0.0 2.0 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF3402 PF11882.3 EWC44565.1 - 2.7e-127 425.2 0.0 5.5e-127 424.2 0.0 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF3402) N1221 PF07923.8 EWC44565.1 - 4.9e-67 225.8 1.7 1.7e-66 224.0 1.1 1.8 1 1 0 1 1 1 1 N1221-like protein Sugar_tr PF00083.19 EWC44566.1 - 5e-69 233.0 25.4 6.3e-69 232.6 17.6 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EWC44566.1 - 2.1e-21 76.0 27.9 3.4e-21 75.3 19.3 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.1 EWC44566.1 - 0.00018 20.0 26.8 0.0035 15.7 3.5 2.8 2 1 1 3 3 3 3 MFS/sugar transport protein DUF3671 PF12420.3 EWC44566.1 - 0.16 11.9 2.4 0.46 10.4 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function IPPT PF01715.12 EWC44567.1 - 1.4e-56 191.3 0.1 6.1e-56 189.2 0.1 1.8 1 1 0 1 1 1 1 IPP transferase DUF1479 PF07350.7 EWC44568.1 - 9.1e-149 495.4 0.0 1e-148 495.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1479) PhyH PF05721.8 EWC44568.1 - 0.00066 19.7 0.1 0.29 11.1 0.1 2.2 2 0 0 2 2 2 2 Phytanoyl-CoA dioxygenase (PhyH) PAP2 PF01569.16 EWC44569.1 - 3.4e-19 68.7 1.7 6.1e-19 67.9 1.1 1.3 1 0 0 1 1 1 1 PAP2 superfamily UbiA PF01040.13 EWC44569.1 - 6.6 5.8 11.9 22 4.1 6.0 2.6 2 1 0 2 2 2 0 UbiA prenyltransferase family Longin PF13774.1 EWC44570.1 - 1.7e-28 97.9 1.1 3.1e-28 97.1 0.8 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.16 EWC44570.1 - 9.8e-17 60.3 0.0 1.6e-16 59.6 0.0 1.3 1 0 0 1 1 1 1 Synaptobrevin DUF1664 PF07889.7 EWC44570.1 - 0.0033 17.2 0.3 0.0061 16.3 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1664) ASXH PF13919.1 EWC44572.1 - 3.2e-22 78.8 0.1 4.6e-22 78.3 0.1 1.2 1 0 0 1 1 1 1 Asx homology domain CENP-I PF07778.6 EWC44573.1 - 6e-82 275.4 0.1 8.2e-82 275.0 0.1 1.1 1 0 0 1 1 1 1 Mis6 TetR PF13972.1 EWC44573.1 - 0.0061 16.0 0.6 0.026 13.9 0.1 2.3 2 0 0 2 2 2 1 Bacterial transcriptional repressor RIC1 PF07064.8 EWC44573.1 - 0.068 12.6 1.2 9.3 5.6 0.1 3.3 4 0 0 4 4 4 0 RIC1 Glyco_hydro_3 PF00933.16 EWC44574.1 - 3.1e-30 105.2 0.0 6e-30 104.2 0.0 1.5 2 0 0 2 2 2 1 Glycosyl hydrolase family 3 N terminal domain Acetyltransf_1 PF00583.19 EWC44574.1 - 6.6e-06 26.0 0.0 2.9e-05 24.0 0.0 2.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 EWC44574.1 - 0.00026 21.0 0.0 0.002 18.2 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 EWC44574.1 - 0.00069 19.7 0.0 0.0024 18.0 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 EWC44574.1 - 0.0021 17.9 0.0 0.021 14.6 0.0 2.4 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Glyco_hydro_3_C PF01915.17 EWC44574.1 - 0.0032 17.0 0.0 0.5 9.8 0.0 2.3 2 0 0 2 2 2 2 Glycosyl hydrolase family 3 C-terminal domain Acetyltransf_CG PF14542.1 EWC44574.1 - 0.038 13.8 0.0 0.081 12.8 0.0 1.5 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Mucin PF01456.12 EWC44575.1 - 0.77 9.5 16.2 0.61 9.8 7.3 2.1 2 0 0 2 2 2 0 Mucin-like glycoprotein Abhydrolase_6 PF12697.2 EWC44576.1 - 2.9e-13 50.2 0.0 4.9e-13 49.4 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EWC44576.1 - 6.3e-12 45.5 0.0 1.7e-11 44.0 0.0 1.7 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EWC44576.1 - 2e-07 30.8 0.0 9.1e-07 28.7 0.0 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family VirJ PF06057.6 EWC44576.1 - 0.035 13.9 0.0 0.054 13.2 0.0 1.3 1 0 0 1 1 1 0 Bacterial virulence protein (VirJ) Cutinase PF01083.17 EWC44576.1 - 0.058 13.1 0.0 0.094 12.4 0.0 1.3 1 0 0 1 1 1 0 Cutinase DUF3818 PF12825.2 EWC44577.1 - 1.2e-39 135.9 0.1 3.9e-24 84.9 0.1 2.3 1 1 1 2 2 2 2 Domain of unknown function in PX-proteins (DUF3818) PXB PF12828.2 EWC44577.1 - 2e-27 95.4 0.0 3.9e-27 94.5 0.0 1.5 1 0 0 1 1 1 1 PX-associated DUF384 PF04064.8 EWC44577.1 - 0.1 12.1 0.0 0.6 9.7 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF384) Ribosomal_60s PF00428.14 EWC44577.1 - 4.5 7.7 13.5 0.3 11.4 1.4 2.8 2 0 0 2 2 2 0 60s Acidic ribosomal protein Lgl_C PF08596.5 EWC44578.1 - 9.3e-85 284.4 0.0 1.1e-58 198.5 0.0 2.3 2 0 0 2 2 2 2 Lethal giant larvae(Lgl) like, C-terminal WD40 PF00400.27 EWC44578.1 - 0.0088 15.9 0.6 28 4.8 0.0 5.2 6 0 0 6 6 6 1 WD domain, G-beta repeat SHMT PF00464.14 EWC44579.1 - 4.3e-206 683.9 0.0 5.1e-206 683.7 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Aminotran_5 PF00266.14 EWC44579.1 - 0.029 13.0 0.0 0.042 12.5 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class-V Baculo_DNA_bind PF04786.7 EWC44579.1 - 0.16 11.0 0.0 0.28 10.3 0.0 1.3 1 0 0 1 1 1 0 ssDNA binding protein Med9 PF07544.8 EWC44580.1 - 3.9e-22 77.7 0.9 8.5e-22 76.6 0.6 1.7 1 0 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 IncA PF04156.9 EWC44580.1 - 0.005 16.4 0.1 0.0051 16.4 0.0 1.2 1 0 0 1 1 1 1 IncA protein BRE1 PF08647.6 EWC44580.1 - 0.082 12.8 4.2 0.15 12.0 0.1 2.7 2 1 0 2 2 2 0 BRE1 E3 ubiquitin ligase Med21 PF11221.3 EWC44580.1 - 0.18 11.7 11.2 0.38 10.7 7.8 1.7 1 1 0 1 1 1 0 Subunit 21 of Mediator complex DUF16 PF01519.11 EWC44580.1 - 0.19 11.9 1.1 0.33 11.1 0.7 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF16 Metalloenzyme PF01676.13 EWC44581.1 - 5.2e-73 245.5 0.0 6e-73 245.3 0.0 1.0 1 0 0 1 1 1 1 Metalloenzyme superfamily iPGM_N PF06415.8 EWC44581.1 - 3.3e-69 232.6 0.0 4.3e-69 232.2 0.0 1.1 1 0 0 1 1 1 1 BPG-independent PGAM N-terminus (iPGM_N) Sulfatase PF00884.18 EWC44581.1 - 4.9e-05 22.6 0.0 0.00091 18.5 0.0 2.3 1 1 0 1 1 1 1 Sulfatase Phosphodiest PF01663.17 EWC44581.1 - 8.4e-05 22.0 0.0 0.00013 21.4 0.0 1.3 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Alk_phosphatase PF00245.15 EWC44581.1 - 0.12 11.0 0.0 0.26 9.9 0.0 1.5 2 0 0 2 2 2 0 Alkaline phosphatase PglZ PF08665.7 EWC44581.1 - 0.13 11.8 0.0 0.38 10.3 0.0 1.7 2 0 0 2 2 2 0 PglZ domain Metallophos PF00149.23 EWC44582.1 - 7.8e-13 48.2 2.9 5.9e-12 45.4 2.0 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase DUF1102 PF06510.6 EWC44582.1 - 0.18 11.6 0.0 0.3 10.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1102) zf-RING_2 PF13639.1 EWC44583.1 - 3.3e-08 33.2 5.2 9.2e-08 31.8 3.6 1.8 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.1 EWC44583.1 - 0.00022 20.8 6.0 0.00022 20.8 4.2 2.0 2 0 0 2 2 2 1 zinc-RING finger domain FANCL_C PF11793.3 EWC44583.1 - 0.00024 21.0 7.1 0.0011 18.8 2.9 2.4 2 0 0 2 2 2 1 FANCL C-terminal domain zf-C3HC4_3 PF13920.1 EWC44583.1 - 0.00026 20.5 4.2 0.00067 19.2 2.9 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) SWIM PF04434.12 EWC44583.1 - 0.00075 18.9 0.1 0.0014 18.0 0.1 1.4 1 0 0 1 1 1 1 SWIM zinc finger zf-C3HC4_2 PF13923.1 EWC44583.1 - 0.00088 19.2 6.9 0.0028 17.6 4.8 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 EWC44583.1 - 0.0011 18.9 7.8 0.0022 18.0 3.5 2.7 2 1 1 3 3 3 1 RING-H2 zinc finger FYVE_2 PF02318.11 EWC44583.1 - 0.0027 17.5 1.6 0.006 16.4 1.1 1.5 1 0 0 1 1 1 1 FYVE-type zinc finger Prok-RING_1 PF14446.1 EWC44583.1 - 0.0044 16.7 2.3 0.0044 16.7 1.6 2.3 1 1 1 2 2 2 1 Prokaryotic RING finger family 1 RINGv PF12906.2 EWC44583.1 - 0.0061 16.5 2.6 0.0061 16.5 1.8 2.1 2 1 0 2 2 1 1 RING-variant domain zf-RING_4 PF14570.1 EWC44583.1 - 0.0092 15.5 5.3 0.0092 15.5 3.7 1.8 2 0 0 2 2 2 1 RING/Ubox like zinc-binding domain C1_1 PF00130.17 EWC44583.1 - 0.01 15.5 2.3 0.01 15.5 1.6 1.9 1 1 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-Apc11 PF12861.2 EWC44583.1 - 0.023 14.5 2.0 0.023 14.5 1.4 2.2 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 11 RING-H2 finger PHD PF00628.24 EWC44583.1 - 0.026 14.1 4.8 0.11 12.1 3.4 2.0 1 1 1 2 2 2 0 PHD-finger zf-RING_UBOX PF13445.1 EWC44583.1 - 0.39 10.4 4.4 0.18 11.5 0.5 2.5 2 1 0 2 2 2 0 RING-type zinc-finger HATPase_c PF02518.21 EWC44585.1 - 1e-26 92.7 0.1 2.1e-26 91.7 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.20 EWC44585.1 - 1.9e-22 79.0 0.1 4.3e-22 77.8 0.1 1.7 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain Response_reg PF00072.19 EWC44585.1 - 1.4e-18 66.9 0.0 1.4e-11 44.4 0.0 2.8 3 0 0 3 3 3 2 Response regulator receiver domain MFS_1 PF07690.11 EWC44586.1 - 5.2e-39 133.9 67.7 1e-38 133.0 43.9 3.1 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.8 EWC44586.1 - 1e-20 73.5 13.8 1e-20 73.5 9.6 1.9 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.19 EWC44586.1 - 1.1e-14 53.8 13.4 1.1e-14 53.8 9.3 2.8 3 1 0 3 3 3 1 Sugar (and other) transporter ATG22 PF11700.3 EWC44586.1 - 0.0096 14.4 24.8 0.11 11.0 0.8 3.0 3 1 0 3 3 3 2 Vacuole effluxer Atg22 like PX PF00787.19 EWC44588.1 - 5.2e-19 68.0 0.0 7.5e-19 67.5 0.0 1.2 1 0 0 1 1 1 1 PX domain Candida_ALS PF05792.8 EWC44589.1 - 0.61 10.2 5.4 1.5 9.0 3.7 1.6 1 0 0 1 1 1 0 Candida agglutinin-like (ALS) CtnDOT_TraJ PF07863.6 EWC44589.1 - 4.4 7.8 7.7 5.1 7.6 0.3 2.5 1 1 1 2 2 2 0 Homologues of TraJ from Bacteroides conjugative transposon PACT_coil_coil PF10495.4 EWC44590.1 - 8.2e-18 64.1 2.5 3.3e-17 62.1 1.7 2.2 1 0 0 1 1 1 1 Pericentrin-AKAP-450 domain of centrosomal targeting protein DUF3584 PF12128.3 EWC44590.1 - 0.026 11.8 90.9 0.1 9.8 16.0 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF3584) Reo_sigmaC PF04582.7 EWC44590.1 - 0.08 12.1 27.7 0.39 9.8 0.7 4.5 1 1 4 5 5 5 0 Reovirus sigma C capsid protein IncA PF04156.9 EWC44590.1 - 1.5 8.3 105.2 0.035 13.6 14.1 5.3 1 1 4 5 5 5 0 IncA protein Tropomyosin PF00261.15 EWC44590.1 - 2.9 6.8 99.0 0.033 13.2 11.6 6.0 2 2 2 5 5 5 0 Tropomyosin AAA_27 PF13514.1 EWC44590.1 - 8.2 3.9 82.6 6.4 4.3 37.5 2.8 1 1 1 2 2 2 0 AAA domain Microtub_assoc PF07989.6 EWC44591.1 - 2.4e-23 81.7 6.2 2.4e-23 81.7 4.3 7.5 2 1 5 9 9 9 1 Microtubule associated Myosin_tail_1 PF01576.14 EWC44591.1 - 0.35 8.5 105.5 0.26 8.9 31.8 3.2 1 1 2 3 3 3 0 Myosin tail WD40_alt PF14077.1 EWC44591.1 - 2.1 8.0 8.8 2.2 7.9 1.4 3.9 3 0 0 3 3 3 0 Alternative WD40 repeat motif AAA_13 PF13166.1 EWC44591.1 - 3.8 5.8 67.1 1.7 6.9 2.2 3.0 1 1 2 3 3 3 0 AAA domain Tropomyosin_1 PF12718.2 EWC44591.1 - 4.2 7.2 101.3 0.02 14.7 15.3 5.7 2 1 4 6 6 6 0 Tropomyosin like Glyco_hydro_17 PF00332.13 EWC44592.1 - 5.7e-06 25.5 0.0 1.2e-05 24.4 0.0 1.6 2 0 0 2 2 2 1 Glycosyl hydrolases family 17 DUF4434 PF14488.1 EWC44592.1 - 0.15 11.7 0.0 0.3 10.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4434) LEA_3 PF03242.8 EWC44593.1 - 5.2 7.3 9.6 13 6.0 0.3 3.9 3 1 0 3 3 3 0 Late embryogenesis abundant protein PP28 PF10252.4 EWC44594.1 - 1.1e-20 73.4 16.3 1.1e-20 73.4 11.3 2.4 1 1 1 2 2 2 1 Casein kinase substrate phosphoprotein PP28 Adeno_PIX PF03955.9 EWC44594.1 - 0.64 10.5 5.1 0.32 11.5 0.7 2.0 1 1 1 2 2 2 0 Adenovirus hexon-associated protein (IX) CENP-B_dimeris PF09026.5 EWC44594.1 - 2.1 8.6 11.6 4 7.7 6.4 2.3 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Acyltransferase PF01553.16 EWC44597.1 - 4.8e-12 45.4 0.0 7.3e-11 41.6 0.0 2.4 1 1 0 1 1 1 1 Acyltransferase Nup96 PF12110.3 EWC44598.1 - 3.6e-84 282.2 0.0 5.1e-84 281.8 0.0 1.2 1 0 0 1 1 1 1 Nuclear protein 96 Nucleoporin2 PF04096.9 EWC44598.1 - 1.3e-43 148.1 0.0 2.3e-43 147.3 0.0 1.4 1 0 0 1 1 1 1 Nucleoporin autopeptidase Nucleoporin_FG PF13634.1 EWC44598.1 - 1.4e-23 83.2 358.1 1.8e-11 44.2 32.0 10.2 3 3 5 8 8 8 6 Nucleoporin FG repeat region EF-hand_1 PF00036.27 EWC44599.1 - 2.8e-19 66.8 8.8 2.8e-07 29.3 0.3 3.6 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.1 EWC44599.1 - 1.9e-18 64.5 4.2 2.3e-06 26.9 0.3 3.8 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.1 EWC44599.1 - 8.8e-18 64.2 2.2 7.2e-13 48.4 0.4 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 EWC44599.1 - 2.3e-16 59.1 9.2 3.4e-11 42.5 0.5 3.6 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.1 EWC44599.1 - 6.9e-08 31.4 10.1 0.0018 17.4 0.4 3.4 3 0 0 3 3 3 3 EF hand Metal_resist PF13801.1 EWC44599.1 - 0.001 19.0 0.1 0.001 19.0 0.1 2.2 3 0 0 3 3 3 1 Heavy-metal resistance EF-hand_4 PF12763.2 EWC44599.1 - 0.0013 18.4 1.1 0.044 13.5 0.0 2.3 1 1 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.1 EWC44599.1 - 0.015 15.1 0.0 2 8.3 0.0 2.2 2 0 0 2 2 2 0 EF-hand domain SPARC_Ca_bdg PF10591.4 EWC44599.1 - 0.065 13.2 0.0 14 5.7 0.0 2.2 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region PAT1 PF09770.4 EWC44599.1 - 6.1 4.9 7.1 7.3 4.7 4.9 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 zf-H2C2_2 PF13465.1 EWC44600.1 - 3.9e-22 77.3 27.5 2.7e-07 30.5 0.7 5.3 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2 PF00096.21 EWC44600.1 - 2.4e-20 71.5 27.3 3.8e-05 23.7 0.6 4.5 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EWC44600.1 - 2.1e-12 46.4 25.9 0.00025 21.1 2.6 4.5 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 EWC44600.1 - 4.4e-08 33.0 7.3 0.078 13.1 0.0 4.4 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 EWC44600.1 - 6.6e-06 26.1 12.1 0.024 14.8 0.4 4.1 4 0 0 4 4 4 3 Zinc-finger of C2H2 type C1_4 PF07975.7 EWC44600.1 - 0.02 14.9 4.4 0.31 11.0 0.0 2.8 1 1 2 3 3 3 0 TFIIH C1-like domain zf-C2H2_6 PF13912.1 EWC44600.1 - 0.05 13.5 16.1 1.3 9.0 0.8 4.2 4 0 0 4 4 4 0 C2H2-type zinc finger XPA_N PF01286.13 EWC44600.1 - 0.096 12.3 0.3 0.096 12.3 0.2 3.3 4 0 0 4 4 4 0 XPA protein N-terminal DUF2072 PF09845.4 EWC44600.1 - 0.11 12.4 0.3 0.29 11.0 0.2 1.7 1 0 0 1 1 1 0 Zn-ribbon containing protein (DUF2072) Zn-ribbon_8 PF09723.5 EWC44600.1 - 0.18 11.7 11.6 12 5.9 0.1 3.9 3 1 1 4 4 4 0 Zinc ribbon domain C1_1 PF00130.17 EWC44600.1 - 0.46 10.2 6.5 0.82 9.4 0.7 2.4 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-TRAF PF02176.13 EWC44600.1 - 1.6 9.1 11.2 3.9 7.9 1.7 2.5 1 1 0 2 2 2 0 TRAF-type zinc finger C1_3 PF07649.7 EWC44600.1 - 8.1 6.5 6.6 19 5.4 0.1 3.1 3 0 0 3 3 3 0 C1-like domain Bromodomain PF00439.20 EWC44601.1 - 4.5e-34 116.2 1.6 1.3e-17 63.5 0.1 2.4 2 0 0 2 2 2 2 Bromodomain DUF3901 PF13040.1 EWC44601.1 - 0.0066 15.7 0.1 1.2 8.4 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF3901) GST_C PF00043.20 EWC44601.1 - 0.13 12.2 0.0 0.45 10.5 0.0 1.9 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain CKS PF01111.14 EWC44602.1 - 8.2e-33 112.0 0.9 2.1e-32 110.7 0.2 1.8 2 0 0 2 2 2 1 Cyclin-dependent kinase regulatory subunit APC_15aa PF05972.6 EWC44602.1 - 0.066 13.2 1.1 0.16 12.0 0.8 1.7 1 0 0 1 1 1 0 APC 15 residue motif PAH PF02671.16 EWC44603.1 - 9.1e-45 150.0 5.4 1.4e-17 63.0 0.5 3.5 3 0 0 3 3 3 3 Paired amphipathic helix repeat Sin3_corepress PF08295.7 EWC44603.1 - 6.6e-41 138.1 0.0 1.7e-40 136.8 0.0 1.8 1 0 0 1 1 1 1 Sin3 family co-repressor Ricin_B_lectin PF00652.17 EWC44605.1 - 0.012 15.6 0.0 0.025 14.5 0.0 1.6 1 1 0 1 1 1 0 Ricin-type beta-trefoil lectin domain Rad60-SLD PF11976.3 EWC44606.1 - 1.1e-16 60.2 3.5 1.8e-16 59.5 1.6 2.0 3 0 0 3 3 3 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.18 EWC44606.1 - 2.4e-06 26.8 0.1 8.9e-05 21.8 0.2 2.9 2 1 1 3 3 3 2 Ubiquitin family TUG-UBL1 PF11470.3 EWC44606.1 - 0.021 14.7 0.0 0.04 13.8 0.0 1.4 1 0 0 1 1 1 0 GLUT4 regulating protein TUG Aminotran_3 PF00202.16 EWC44607.1 - 8.4e-102 340.4 0.0 1.5e-98 329.8 0.0 2.1 2 0 0 2 2 2 2 Aminotransferase class-III Beta_elim_lyase PF01212.16 EWC44607.1 - 0.007 15.5 0.0 0.013 14.6 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.16 EWC44607.1 - 0.029 13.3 0.0 0.069 12.0 0.0 1.6 2 0 0 2 2 2 0 Aminotransferase class I and II Suf PF05843.9 EWC44608.1 - 0.00018 21.3 2.8 0.038 13.7 0.0 3.3 2 1 0 3 3 3 2 Suppressor of forked protein (Suf) TPR_14 PF13428.1 EWC44608.1 - 0.044 14.4 3.4 1e+02 3.9 0.1 5.8 6 1 1 7 7 7 0 Tetratricopeptide repeat Peptidase_M1 PF01433.15 EWC44609.1 - 1.3e-148 495.3 0.5 1.3e-148 495.3 0.3 1.4 2 0 0 2 2 2 1 Peptidase family M1 ERAP1_C PF11838.3 EWC44609.1 - 6.5e-91 304.9 0.2 1e-89 301.0 0.0 2.4 2 0 0 2 2 2 1 ERAP1-like C-terminal domain Peptidase_MA_2 PF13485.1 EWC44609.1 - 1.7e-19 70.1 0.1 3.8e-19 68.9 0.0 1.6 1 0 0 1 1 1 1 Peptidase MA superfamily Aminotran_3 PF00202.16 EWC44610.1 - 5.8e-82 275.2 0.0 6.7e-82 275.0 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.16 EWC44610.1 - 0.029 13.3 0.0 0.036 13.0 0.0 1.1 1 0 0 1 1 1 0 Aminotransferase class I and II DUF1662 PF07878.6 EWC44610.1 - 0.063 13.0 0.1 4.5 7.0 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1662) Beta_elim_lyase PF01212.16 EWC44610.1 - 0.12 11.5 0.0 0.2 10.7 0.0 1.4 1 0 0 1 1 1 0 Beta-eliminating lyase DEAD PF00270.24 EWC44611.1 - 1.6e-40 138.3 0.0 1.7e-39 135.0 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EWC44611.1 - 1e-25 89.4 0.1 2.2e-25 88.3 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF2986 PF11661.3 EWC44611.1 - 0.0038 17.5 3.5 0.0038 17.5 2.5 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF2986) His_Phos_1 PF00300.17 EWC44612.1 - 1.9e-16 60.5 0.0 3.1e-16 59.8 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) G-patch_2 PF12656.2 EWC44613.1 - 1e-25 89.3 0.1 1e-25 89.3 0.1 2.6 2 0 0 2 2 2 1 DExH-box splicing factor binding site G-patch PF01585.18 EWC44613.1 - 0.00013 21.7 1.7 0.00032 20.4 1.2 1.8 1 0 0 1 1 1 1 G-patch domain HMG_box PF00505.14 EWC44614.1 - 8.6e-14 51.5 0.5 2.1e-13 50.3 0.4 1.7 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 EWC44614.1 - 2.3e-12 47.0 0.5 4.7e-12 46.0 0.4 1.5 1 0 0 1 1 1 1 HMG-box domain SAM_1 PF00536.25 EWC44614.1 - 1e-05 25.6 0.1 1.8e-05 24.8 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.12 EWC44614.1 - 0.003 17.3 0.7 0.034 13.9 0.1 2.2 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) Tol_Tol_Ttg2 PF05494.7 EWC44614.1 - 0.022 14.3 0.2 0.035 13.6 0.1 1.2 1 0 0 1 1 1 0 Toluene tolerance, Ttg2 CobT PF06213.7 EWC44615.1 - 0.037 13.1 7.5 0.041 13.0 5.2 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT IFT46_B_C PF12317.3 EWC44615.1 - 0.13 11.5 0.2 0.14 11.5 0.1 1.2 1 0 0 1 1 1 0 Intraflagellar transport complex B protein 46 C terminal PI3K_1B_p101 PF10486.4 EWC44615.1 - 0.42 8.1 2.4 0.48 7.9 1.7 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Sporozoite_P67 PF05642.6 EWC44615.1 - 0.64 7.8 4.3 0.72 7.6 3.0 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Med17 PF10156.4 EWC44615.1 - 1.2 7.3 4.9 1.3 7.2 3.4 1.0 1 0 0 1 1 1 0 Subunit 17 of Mediator complex DUF4611 PF15387.1 EWC44615.1 - 1.4 9.0 7.7 1.8 8.7 5.4 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4611) PPTA PF01239.17 EWC44616.1 - 8.7e-48 157.7 4.1 1.3e-09 36.9 0.2 5.3 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat DUF4219 PF13961.1 EWC44616.1 - 0.28 10.6 6.6 13 5.3 0.2 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4219) NLE PF08154.7 EWC44618.1 - 1.4e-21 76.2 0.1 2.4e-21 75.4 0.1 1.4 1 0 0 1 1 1 1 NLE (NUC135) domain WD40 PF00400.27 EWC44618.1 - 3.1e-21 74.4 17.0 1.7e-07 30.8 1.1 6.2 6 0 0 6 6 6 5 WD domain, G-beta repeat GHMP_kinases_N PF00288.21 EWC44619.1 - 2.8e-19 68.9 0.1 5.4e-19 68.0 0.1 1.5 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.8 EWC44619.1 - 2.8e-08 33.8 0.0 6.2e-08 32.7 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal APG5 PF04106.7 EWC44620.1 - 4.5e-56 189.4 0.0 6e-56 189.0 0.0 1.2 1 0 0 1 1 1 1 Autophagy protein Apg5 TauD PF02668.11 EWC44620.1 - 2.2e-21 76.6 0.0 4.3e-21 75.7 0.0 1.5 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family NUC130_3NT PF08158.7 EWC44620.1 - 0.031 14.5 0.0 1 9.6 0.0 2.5 2 0 0 2 2 2 0 NUC130/3NT domain Sod_Fe_C PF02777.13 EWC44621.1 - 1.7e-16 59.9 0.1 6.1e-08 32.4 0.1 2.7 3 0 0 3 3 3 2 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.17 EWC44621.1 - 0.047 13.9 0.1 0.091 13.0 0.1 1.5 1 0 0 1 1 1 0 Iron/manganese superoxide dismutases, alpha-hairpin domain HSP20 PF00011.16 EWC44622.1 - 3.2e-12 46.2 0.0 1.3e-08 34.6 0.0 2.3 2 0 0 2 2 2 2 Hsp20/alpha crystallin family DUF3446 PF11928.3 EWC44622.1 - 0.54 10.4 4.2 3.4 7.9 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3446) DUF3376 PF11856.3 EWC44623.1 - 0.0045 16.4 1.4 0.0045 16.4 1.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF3376) CCDC-167 PF15188.1 EWC44623.1 - 0.013 15.3 0.7 0.037 13.9 0.5 1.7 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 DUF445 PF04286.7 EWC44623.1 - 0.14 11.6 2.9 0.14 11.7 0.5 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF445) CENP-F_leu_zip PF10473.4 EWC44623.1 - 0.17 11.7 5.5 0.074 12.9 2.0 1.7 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Response_reg PF00072.19 EWC44625.1 - 1.7e-18 66.6 0.8 3.6e-18 65.6 0.1 1.9 2 0 0 2 2 2 1 Response regulator receiver domain HATPase_c PF02518.21 EWC44625.1 - 9e-15 54.3 0.0 1.7e-14 53.5 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.20 EWC44625.1 - 8e-08 32.1 0.1 3.6e-07 30.0 0.1 2.1 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HATPase_c_3 PF13589.1 EWC44625.1 - 0.062 12.9 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase GAF_2 PF13185.1 EWC44625.1 - 0.12 12.8 0.0 0.29 11.5 0.0 1.6 1 0 0 1 1 1 0 GAF domain WD40 PF00400.27 EWC44626.1 - 1.1e-06 28.3 0.3 2e-06 27.4 0.2 1.4 1 0 0 1 1 1 1 WD domain, G-beta repeat UAF_Rrn10 PF05234.6 EWC44627.1 - 2.8e-07 30.6 0.0 5.5e-07 29.6 0.0 1.6 2 1 0 2 2 2 1 UAF complex subunit Rrn10 Methyltransf_23 PF13489.1 EWC44628.1 - 6.1e-15 55.3 0.1 1e-14 54.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EWC44628.1 - 3.6e-14 53.0 0.0 1.3e-13 51.1 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 EWC44628.1 - 3.5e-10 40.2 0.0 7.8e-10 39.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EWC44628.1 - 3.8e-10 39.5 0.0 6.5e-10 38.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EWC44628.1 - 2.7e-09 37.3 0.0 5.8e-09 36.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EWC44628.1 - 1.6e-07 31.9 0.0 2.9e-07 31.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EWC44628.1 - 6e-05 23.0 0.0 0.00012 22.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain DUF3419 PF11899.3 EWC44628.1 - 0.0014 17.4 0.0 0.0022 16.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3419) NNMT_PNMT_TEMT PF01234.12 EWC44628.1 - 0.018 14.0 0.0 3.9 6.3 0.0 2.3 2 0 0 2 2 2 0 NNMT/PNMT/TEMT family Methyltransf_4 PF02390.12 EWC44628.1 - 0.044 12.8 0.0 0.077 12.0 0.0 1.4 1 1 0 1 1 1 0 Putative methyltransferase MTS PF05175.9 EWC44628.1 - 0.088 12.1 0.0 0.18 11.1 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase small domain LSM PF01423.17 EWC44629.1 - 4.3e-20 71.0 0.1 4.8e-20 70.8 0.0 1.0 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.1 EWC44629.1 - 0.012 15.4 0.0 0.015 15.2 0.0 1.2 1 0 0 1 1 1 0 Ataxin 2 SM domain Acetyltransf_1 PF00583.19 EWC44630.1 - 2.1e-06 27.6 0.0 3.8e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 EWC44630.1 - 2.1e-05 24.5 0.0 3.3e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 EWC44630.1 - 0.0019 18.0 0.0 2.3 8.1 0.0 2.2 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Fungal_trans_2 PF11951.3 EWC44632.1 - 4.2e-60 203.3 0.0 5.2e-60 203.0 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EWC44632.1 - 5.5e-08 32.5 7.5 9.2e-08 31.8 5.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SAM_2 PF07647.12 EWC44633.1 - 1.5e-12 47.1 0.6 3.1e-12 46.1 0.4 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.25 EWC44633.1 - 9.4e-11 41.7 0.7 2.9e-10 40.1 0.5 1.9 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Ste50p-SAM PF09235.5 EWC44633.1 - 2e-05 24.5 0.1 5.4e-05 23.1 0.0 1.8 1 0 0 1 1 1 1 Ste50p, sterile alpha motif SAM_PNT PF02198.11 EWC44633.1 - 0.0028 17.3 0.4 0.0054 16.4 0.3 1.4 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain PH PF00169.24 EWC44633.1 - 0.0052 16.9 0.1 0.015 15.4 0.1 1.8 1 0 0 1 1 1 1 PH domain MARVEL PF01284.18 EWC44634.1 - 8.7e-05 22.3 12.5 0.0077 16.0 6.0 2.5 1 1 1 2 2 2 2 Membrane-associating domain DUF4149 PF13664.1 EWC44634.1 - 0.017 15.1 1.5 0.017 15.1 1.0 2.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4149) SUR7 PF06687.7 EWC44634.1 - 0.032 13.8 7.2 0.049 13.1 0.1 2.2 1 1 0 2 2 2 0 SUR7/PalI family DUF898 PF05987.8 EWC44634.1 - 0.051 12.4 4.6 0.34 9.7 0.3 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF898) CTV_P33 PF07184.6 EWC44634.1 - 0.064 12.0 0.0 0.4 9.4 0.0 1.9 2 0 0 2 2 2 0 Citrus tristeza virus P33 protein TctB PF07331.6 EWC44634.1 - 0.069 12.8 4.2 0.042 13.5 0.8 2.0 2 0 0 2 2 2 0 Tripartite tricarboxylate transporter TctB family Ni_hydr_CYTB PF01292.15 EWC44634.1 - 0.093 12.1 5.3 0.035 13.5 1.8 1.6 2 0 0 2 2 2 0 Prokaryotic cytochrome b561 NPCC PF08058.6 EWC44634.1 - 0.12 12.2 1.6 9 6.1 0.4 2.4 2 1 0 2 2 2 0 Nuclear pore complex component CoA_binding_3 PF13727.1 EWC44634.1 - 0.16 11.7 5.7 0.057 13.2 1.4 2.0 2 0 0 2 2 2 0 CoA-binding domain DUF1640 PF07798.6 EWC44635.1 - 8.2e-61 205.1 9.6 9.4e-61 204.9 6.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) MutS_II PF05188.12 EWC44635.1 - 0.035 14.1 2.6 0.083 12.9 1.8 1.6 1 1 0 1 1 1 0 MutS domain II DNAPolymera_Pol PF11590.3 EWC44635.1 - 0.04 13.6 0.1 1.6 8.4 0.1 2.6 2 0 0 2 2 2 0 DNA polymerase catalytic subunit Pol DUF1192 PF06698.6 EWC44635.1 - 0.053 13.3 5.9 2.2 8.1 1.2 3.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1192) Neurensin PF14927.1 EWC44635.1 - 0.076 12.4 0.1 0.37 10.1 0.0 2.0 2 0 0 2 2 2 0 Neurensin HalX PF08663.5 EWC44635.1 - 0.086 12.8 3.5 0.086 12.8 0.6 2.3 2 1 0 2 2 2 0 HalX domain DUF883 PF05957.8 EWC44635.1 - 0.34 11.3 4.9 0.42 11.0 0.6 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) OmpH PF03938.9 EWC44635.1 - 0.57 10.0 5.8 0.24 11.3 1.6 1.9 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) GreA_GreB_N PF03449.10 EWC44635.1 - 5.5 7.1 7.9 4.3 7.4 3.9 2.0 2 1 0 2 2 2 0 Transcription elongation factor, N-terminal DOPA_dioxygen PF08883.6 EWC44636.1 - 4.3e-34 116.7 0.4 6.2e-34 116.1 0.3 1.3 1 0 0 1 1 1 1 Dopa 4,5-dioxygenase family Ring_hydroxyl_A PF00848.14 EWC44636.1 - 0.064 12.8 0.1 0.097 12.3 0.1 1.3 1 0 0 1 1 1 0 Ring hydroxylating alpha subunit (catalytic domain) PEX11 PF05648.9 EWC44637.1 - 7.9e-18 64.5 0.5 2.3e-13 49.9 0.3 2.5 2 1 0 2 2 2 2 Peroxisomal biogenesis factor 11 (PEX11) Herpes_gE PF02480.11 EWC44637.1 - 0.087 11.0 0.4 0.13 10.4 0.3 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E G-patch PF01585.18 EWC44638.1 - 0.0023 17.6 0.1 0.0073 16.0 0.0 2.0 1 1 0 1 1 1 1 G-patch domain CAF-1_p150 PF11600.3 EWC44638.1 - 0.0096 15.3 27.2 0.0096 15.3 18.8 1.8 2 0 0 2 2 2 1 Chromatin assembly factor 1 complex p150 subunit, N-terminal Nop53 PF07767.6 EWC44638.1 - 0.013 14.4 25.8 0.018 14.0 17.9 1.2 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Borrelia_P83 PF05262.6 EWC44638.1 - 0.031 12.5 12.9 0.048 11.9 8.9 1.3 1 0 0 1 1 1 0 Borrelia P83/100 protein Dsh_C PF12316.3 EWC44638.1 - 1.6 8.8 12.1 3.2 7.7 8.4 1.6 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal DUF2992 PF11208.3 EWC44638.1 - 2.1 8.2 21.0 4.1 7.3 14.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2992) CDC45 PF02724.9 EWC44638.1 - 2.8 5.8 19.2 3.8 5.4 13.3 1.3 1 0 0 1 1 1 0 CDC45-like protein RR_TM4-6 PF06459.7 EWC44638.1 - 6.4 6.5 17.3 9.8 5.9 12.0 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PMM PF03332.8 EWC44639.1 - 9.2e-102 339.2 0.7 1e-101 339.1 0.5 1.0 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase TMPIT PF07851.8 EWC44639.1 - 0.17 10.9 0.0 0.22 10.5 0.0 1.1 1 0 0 1 1 1 0 TMPIT-like protein cobW PF02492.14 EWC44640.1 - 5.2e-36 123.7 0.0 7.4e-36 123.2 0.0 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain Viral_helicase1 PF01443.13 EWC44640.1 - 0.027 14.0 0.0 0.048 13.1 0.0 1.5 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase CobW_C PF07683.9 EWC44640.1 - 0.034 13.8 0.0 0.21 11.3 0.0 2.2 1 1 0 1 1 1 0 Cobalamin synthesis protein cobW C-terminal domain MobB PF03205.9 EWC44640.1 - 0.11 12.1 0.0 0.23 11.1 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Ank_2 PF12796.2 EWC44641.1 - 6.8e-44 148.1 6.1 1.3e-14 54.2 0.0 6.6 2 1 5 8 8 8 8 Ankyrin repeats (3 copies) Ank_4 PF13637.1 EWC44641.1 - 1.2e-30 105.2 0.7 4.3e-05 23.9 0.0 9.1 4 2 6 10 10 10 7 Ankyrin repeats (many copies) Ank_5 PF13857.1 EWC44641.1 - 9.7e-30 101.9 0.9 0.0045 17.1 0.0 8.6 7 1 1 8 8 8 7 Ankyrin repeats (many copies) Ank PF00023.25 EWC44641.1 - 6e-26 88.9 8.5 0.059 13.2 0.0 11.5 12 0 0 12 12 12 7 Ankyrin repeat Ank_3 PF13606.1 EWC44641.1 - 5e-22 75.7 0.3 0.27 11.5 0.0 11.9 13 0 0 13 13 13 3 Ankyrin repeat SPRY PF00622.23 EWC44641.1 - 2.5e-08 34.0 0.1 4.8e-08 33.1 0.1 1.5 1 0 0 1 1 1 1 SPRY domain AAA_16 PF13191.1 EWC44641.1 - 1.5e-07 31.6 0.0 7.8e-07 29.2 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain NACHT PF05729.7 EWC44641.1 - 1.9e-06 27.6 0.0 5.4e-06 26.1 0.0 1.8 1 0 0 1 1 1 1 NACHT domain Ank_2 PF12796.2 EWC44643.1 - 9.3e-76 250.2 16.0 5.6e-22 77.8 0.3 4.7 2 2 3 5 5 5 5 Ankyrin repeats (3 copies) Ank PF00023.25 EWC44643.1 - 5.5e-60 196.3 9.3 8.3e-10 37.9 0.0 10.3 10 0 0 10 10 10 9 Ankyrin repeat Ank_4 PF13637.1 EWC44643.1 - 2e-45 152.3 11.2 8.6e-12 45.2 0.0 6.8 4 1 3 7 7 7 6 Ankyrin repeats (many copies) Ank_3 PF13606.1 EWC44643.1 - 3.8e-42 138.0 11.0 8.7e-05 22.4 0.0 10.2 10 0 0 10 10 10 9 Ankyrin repeat Ank_5 PF13857.1 EWC44643.1 - 1.6e-36 123.5 13.4 1.6e-08 34.5 0.0 7.7 1 1 7 9 9 9 7 Ankyrin repeats (many copies) EPSP_synthase PF00275.15 EWC44643.1 - 0.038 12.4 0.5 3.7 5.8 0.1 2.6 2 1 1 3 3 3 0 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) EF-hand_4 PF12763.2 EWC44643.1 - 0.14 11.8 0.0 0.28 10.9 0.0 1.4 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand EVE PF01878.13 EWC44649.1 - 2.2e-49 167.1 0.0 2.4e-49 167.0 0.0 1.0 1 0 0 1 1 1 1 EVE domain bZIP_2 PF07716.10 EWC44650.1 - 0.00012 21.8 10.9 0.00021 21.0 7.6 1.3 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.16 EWC44650.1 - 0.35 10.8 9.2 0.75 9.7 6.4 1.5 1 0 0 1 1 1 0 bZIP transcription factor Aldedh PF00171.17 EWC44651.1 - 3.5e-179 595.9 0.1 4e-179 595.7 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Lantibiotic_a PF14867.1 EWC44651.1 - 0.001 18.2 0.1 0.002 17.3 0.1 1.4 1 0 0 1 1 1 1 Lantibiotic alpha LuxC PF05893.9 EWC44651.1 - 0.0062 15.2 0.0 0.0097 14.6 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA reductase (LuxC) TAXi_C PF14541.1 EWC44651.1 - 0.021 14.3 0.0 0.048 13.2 0.0 1.7 1 0 0 1 1 1 0 Xylanase inhibitor C-terminal DUF1487 PF07368.6 EWC44651.1 - 0.13 11.5 0.0 1.2 8.3 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1487) Aldedh PF00171.17 EWC44652.1 - 3.6e-163 543.2 0.2 4e-163 543.0 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Ldh_2 PF02615.9 EWC44652.1 - 0.029 13.0 0.4 0.047 12.3 0.3 1.3 1 0 0 1 1 1 0 Malate/L-lactate dehydrogenase Phage_cap_E PF03864.10 EWC44652.1 - 0.14 11.0 0.1 0.24 10.2 0.0 1.3 1 0 0 1 1 1 0 Phage major capsid protein E Thioredoxin_4 PF13462.1 EWC44653.1 - 9.6e-05 22.4 0.0 0.00021 21.3 0.0 1.5 1 1 0 1 1 1 1 Thioredoxin UvrD_C PF13361.1 EWC44654.1 - 5.9e-74 249.6 0.0 2.2e-73 247.7 0.0 2.0 3 0 0 3 3 3 1 UvrD-like helicase C-terminal domain UvrD-helicase PF00580.16 EWC44654.1 - 1.2e-60 205.5 6.4 1.5e-60 205.1 1.0 2.8 2 1 0 2 2 2 1 UvrD/REP helicase N-terminal domain UvrD_C_2 PF13538.1 EWC44654.1 - 2e-13 50.3 0.0 9.5e-13 48.1 0.0 2.1 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain AAA_19 PF13245.1 EWC44654.1 - 1.3e-11 44.0 0.1 4.8e-11 42.2 0.0 2.0 2 0 0 2 2 2 1 Part of AAA domain AAA_30 PF13604.1 EWC44654.1 - 9.7e-06 25.2 0.0 0.0002 20.9 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.1 EWC44654.1 - 6.1e-05 22.7 1.2 0.00032 20.3 0.1 2.6 2 1 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.13 EWC44654.1 - 6.2e-05 22.6 1.5 0.88 9.0 0.0 3.7 4 0 0 4 4 4 2 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.1 EWC44654.1 - 0.0023 18.0 0.2 0.63 10.1 0.0 2.7 2 0 0 2 2 2 1 AAA domain Cyclin_N PF00134.18 EWC44655.1 - 4.7e-39 132.8 1.5 3.3e-38 130.1 0.1 2.2 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.14 EWC44655.1 - 5.5e-14 52.1 0.5 1.4e-13 50.7 0.4 1.7 1 0 0 1 1 1 1 Cyclin, C-terminal domain CBM_1 PF00734.13 EWC44656.1 - 1.7e-12 46.7 11.0 6.7e-12 44.8 7.7 2.1 1 0 0 1 1 1 1 Fungal cellulose binding domain BNR PF02012.15 EWC44656.1 - 2.6e-10 38.5 35.9 0.55 10.2 0.1 9.9 9 0 0 9 9 9 7 BNR/Asp-box repeat Glyco_hydro_18 PF00704.23 EWC44657.1 - 1.9e-12 47.3 0.0 3.8e-12 46.3 0.0 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 Grp1_Fun34_YaaH PF01184.14 EWC44658.1 - 9.4e-78 260.3 13.7 1.2e-77 259.9 9.5 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family DUF3623 PF12291.3 EWC44658.1 - 1.6 7.6 11.1 3.6 6.4 2.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3623) PIP5K PF01504.13 EWC44660.1 - 8.1e-62 208.5 0.6 1.5e-61 207.6 0.4 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Cpn60_TCP1 PF00118.19 EWC44660.1 - 1e-23 83.7 0.1 1.6e-23 83.0 0.1 1.2 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family FYVE PF01363.16 EWC44660.1 - 1.9e-14 53.3 12.1 1.9e-14 53.3 8.4 1.8 2 0 0 2 2 2 1 FYVE zinc finger IBR PF01485.16 EWC44660.1 - 3.3 7.6 12.1 1 9.2 6.0 1.9 2 0 0 2 2 2 0 IBR domain LSM PF01423.17 EWC44662.1 - 2.3e-08 33.4 0.0 2.9e-08 33.1 0.0 1.1 1 0 0 1 1 1 1 LSM domain LSM14 PF12701.2 EWC44662.1 - 0.033 14.0 0.0 0.041 13.6 0.0 1.1 1 0 0 1 1 1 0 Scd6-like Sm domain Ribosomal_S17 PF00366.15 EWC44663.1 - 8.4e-28 96.2 0.9 1.3e-27 95.6 0.6 1.3 1 0 0 1 1 1 1 Ribosomal protein S17 tRNA_lig_CPD PF08302.6 EWC44663.1 - 0.028 13.6 0.0 0.046 12.9 0.0 1.4 1 0 0 1 1 1 0 Fungal tRNA ligase phosphodiesterase domain Spc7 PF08317.6 EWC44664.1 - 2.7e-73 246.4 10.2 4.3e-73 245.8 7.0 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein Spc7_N PF15402.1 EWC44664.1 - 5.2e-61 206.8 81.2 5.4e-35 120.7 15.1 5.9 2 1 4 6 6 6 4 N-terminus of kinetochore NMS complex subunit Spc7 Spc7_C2 PF15577.1 EWC44664.1 - 0.0002 20.9 0.0 0.00037 20.0 0.0 1.5 1 0 0 1 1 1 1 Spc7_C2 SUR7 PF06687.7 EWC44665.1 - 3e-32 111.9 13.8 3.6e-32 111.6 9.5 1.1 1 0 0 1 1 1 1 SUR7/PalI family GTP_EFTU PF00009.22 EWC44666.1 - 1.7e-56 190.6 1.2 2.9e-56 189.8 0.1 1.9 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.13 EWC44666.1 - 6.6e-34 116.0 0.1 1.5e-33 114.8 0.1 1.7 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.1 EWC44666.1 - 7.4e-33 112.2 0.0 2e-32 110.8 0.0 1.8 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.19 EWC44666.1 - 2.2e-21 75.5 0.0 2.8e-19 68.7 0.0 2.6 2 0 0 2 2 2 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.20 EWC44666.1 - 5.1e-10 39.3 0.1 1.5e-09 37.8 0.0 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 DUF442 PF04273.8 EWC44666.1 - 0.049 13.4 0.0 1.7 8.5 0.0 2.7 2 0 0 2 2 2 0 Putative phosphatase (DUF442) Polysacc_synt_4 PF04669.8 EWC44667.1 - 2e-21 76.2 1.6 1.6e-20 73.2 1.1 1.9 1 1 0 1 1 1 1 Polysaccharide biosynthesis Cor1 PF04803.7 EWC44667.1 - 0.022 14.5 0.6 0.038 13.7 0.4 1.4 1 0 0 1 1 1 0 Cor1/Xlr/Xmr conserved region DUF4415 PF14384.1 EWC44667.1 - 0.072 13.2 0.6 3.7 7.7 0.4 2.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4415) Kunitz_legume PF00197.13 EWC44667.1 - 0.11 12.0 0.1 1.7 8.1 0.0 2.0 1 1 1 2 2 2 0 Trypsin and protease inhibitor ABC_membrane PF00664.18 EWC44668.1 - 3.5e-72 243.0 23.6 7e-37 127.3 4.3 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 EWC44668.1 - 1.3e-65 219.8 0.0 3.5e-32 111.5 0.0 2.4 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 EWC44668.1 - 8.7e-11 42.3 0.0 0.01 15.8 0.0 4.9 5 0 0 5 5 5 2 AAA domain AAA_17 PF13207.1 EWC44668.1 - 9.6e-10 39.3 0.0 0.0028 18.4 0.0 2.9 2 0 0 2 2 2 2 AAA domain SMC_N PF02463.14 EWC44668.1 - 1.6e-09 37.3 0.0 0.0023 17.2 0.0 3.8 2 2 1 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.1 EWC44668.1 - 4.9e-09 36.4 0.0 0.00024 21.1 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain DUF258 PF03193.11 EWC44668.1 - 6e-08 32.0 0.1 0.00081 18.6 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_18 PF13238.1 EWC44668.1 - 1.8e-07 31.5 0.0 0.0086 16.3 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.1 EWC44668.1 - 5.6e-07 29.0 0.4 0.03 13.8 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.1 EWC44668.1 - 9.7e-07 28.9 0.1 1.1 9.4 0.1 3.7 3 1 0 3 3 3 2 AAA domain AAA_10 PF12846.2 EWC44668.1 - 3.3e-06 26.7 2.3 0.047 13.1 0.1 4.0 4 0 0 4 4 4 2 AAA-like domain AAA_25 PF13481.1 EWC44668.1 - 2.5e-05 23.7 0.0 0.27 10.6 0.0 2.9 2 0 0 2 2 2 2 AAA domain NACHT PF05729.7 EWC44668.1 - 5.7e-05 22.8 0.1 0.038 13.6 0.0 2.5 2 0 0 2 2 2 1 NACHT domain AAA_33 PF13671.1 EWC44668.1 - 7.2e-05 22.6 0.1 0.31 10.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.18 EWC44668.1 - 0.00025 20.9 0.0 0.22 11.5 0.0 2.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase IstB_IS21 PF01695.12 EWC44668.1 - 0.00031 20.1 0.0 0.71 9.2 0.0 3.5 4 0 0 4 4 3 1 IstB-like ATP binding protein APS_kinase PF01583.15 EWC44668.1 - 0.00049 19.7 0.1 1.4 8.5 0.0 2.6 2 0 0 2 2 2 2 Adenylylsulphate kinase AAA_5 PF07728.9 EWC44668.1 - 0.00068 19.3 0.5 0.93 9.2 0.0 3.9 4 0 0 4 4 4 1 AAA domain (dynein-related subfamily) RNA_helicase PF00910.17 EWC44668.1 - 0.0008 19.5 0.1 0.16 12.1 0.0 2.9 3 0 0 3 3 2 1 RNA helicase DUF87 PF01935.12 EWC44668.1 - 0.00083 19.2 1.1 0.27 11.0 0.0 2.8 2 0 0 2 2 2 1 Domain of unknown function DUF87 PRK PF00485.13 EWC44668.1 - 0.0013 18.3 0.0 0.73 9.3 0.0 2.5 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family Zeta_toxin PF06414.7 EWC44668.1 - 0.0014 17.7 0.1 1.3 8.0 0.0 2.4 2 0 0 2 2 2 2 Zeta toxin AAA_23 PF13476.1 EWC44668.1 - 0.002 18.4 0.1 1.8 8.8 0.0 2.3 2 0 0 2 2 2 1 AAA domain MobB PF03205.9 EWC44668.1 - 0.0029 17.3 0.1 3.5 7.3 0.0 2.6 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B NB-ARC PF00931.17 EWC44668.1 - 0.0035 16.2 0.3 1.4 7.7 0.1 2.2 2 0 0 2 2 2 1 NB-ARC domain AAA_30 PF13604.1 EWC44668.1 - 0.0092 15.5 0.0 2.2 7.8 0.0 2.6 2 0 0 2 2 2 1 AAA domain SbcCD_C PF13558.1 EWC44668.1 - 0.018 14.9 0.5 2.2 8.2 0.0 3.4 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_14 PF13173.1 EWC44668.1 - 0.018 14.9 0.0 10 6.0 0.0 3.1 3 0 0 3 3 2 0 AAA domain ACR_tran PF00873.14 EWC44668.1 - 0.019 12.4 0.1 0.028 11.8 0.0 1.1 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family ATP-synt_ab PF00006.20 EWC44668.1 - 0.021 14.3 0.1 1 8.8 0.0 2.8 3 0 0 3 3 3 0 ATP synthase alpha/beta family, nucleotide-binding domain Mg_chelatase PF01078.16 EWC44668.1 - 0.033 13.3 0.0 4.5 6.3 0.0 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.21 EWC44668.1 - 0.048 13.1 0.0 4.5 6.7 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_28 PF13521.1 EWC44668.1 - 0.06 13.3 0.5 14 5.6 0.1 2.6 2 0 0 2 2 2 0 AAA domain T2SE PF00437.15 EWC44668.1 - 0.072 11.9 0.0 0.63 8.8 0.0 2.1 2 0 0 2 2 2 0 Type II/IV secretion system protein KaiC PF06745.8 EWC44668.1 - 0.076 12.1 0.4 12 4.8 0.0 2.4 2 0 0 2 2 2 0 KaiC Miro PF08477.8 EWC44668.1 - 0.11 13.0 0.5 6.7 7.2 0.0 2.7 2 0 0 2 2 2 0 Miro-like protein Adeno_IVa2 PF02456.10 EWC44668.1 - 0.11 11.1 0.0 12 4.3 0.0 2.3 2 0 0 2 2 2 0 Adenovirus IVa2 protein Dynamin_N PF00350.18 EWC44668.1 - 0.21 11.4 0.4 13 5.5 0.0 2.4 2 0 0 2 2 2 0 Dynamin family Septin PF00735.13 EWC44668.1 - 0.25 10.3 0.2 1.5 7.7 0.1 2.1 2 0 0 2 2 2 0 Septin ABC_ATPase PF09818.4 EWC44668.1 - 0.44 9.0 1.0 38 2.6 0.0 3.4 3 1 0 3 3 3 0 Predicted ATPase of the ABC class AAA_24 PF13479.1 EWC44668.1 - 0.49 9.9 0.9 21 4.5 0.1 2.6 2 0 0 2 2 2 0 AAA domain RIC3 PF15361.1 EWC44669.1 - 1.3 9.2 0.0 1.3 9.2 0.0 2.5 2 1 0 3 3 3 0 Resistance to inhibitors of cholinesterase homologue 3 Adeno_E3_CR2 PF02439.10 EWC44669.1 - 6.1 6.4 7.1 11 5.6 4.9 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Rad4 PF03835.10 EWC44670.1 - 3.2e-15 55.7 2.1 3.2e-15 55.7 1.4 1.7 2 0 0 2 2 2 1 Rad4 transglutaminase-like domain Transglut_core PF01841.14 EWC44670.1 - 1.3e-13 51.1 1.3 3.2e-13 49.8 0.9 1.7 1 0 0 1 1 1 1 Transglutaminase-like superfamily Cupin_2 PF07883.6 EWC44671.1 - 1.1e-08 34.3 0.3 5.4e-08 32.2 0.0 2.0 2 0 0 2 2 2 1 Cupin domain Cupin_1 PF00190.17 EWC44671.1 - 0.017 14.5 0.1 0.034 13.5 0.0 1.5 2 0 0 2 2 2 0 Cupin FIST_C PF10442.4 EWC44671.1 - 0.025 14.5 0.0 0.049 13.5 0.0 1.6 1 0 0 1 1 1 0 FIST C domain Cupin_3 PF05899.7 EWC44671.1 - 0.11 11.9 0.1 0.21 10.9 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF861) Raptor_N PF14538.1 EWC44672.1 - 0.0052 16.6 1.5 0.49 10.2 0.0 2.7 3 0 0 3 3 3 2 Raptor N-terminal CASPase like domain Pil1 PF13805.1 EWC44673.1 - 2.6e-153 508.8 0.2 3.2e-153 508.5 0.2 1.1 1 0 0 1 1 1 1 Eisosome component PIL1 TniQ PF06527.6 EWC44673.1 - 0.0073 16.5 0.0 0.019 15.1 0.0 1.7 1 0 0 1 1 1 1 TniQ FAM92 PF06730.6 EWC44673.1 - 0.046 13.0 3.8 0.2 10.9 2.6 1.9 1 1 0 1 1 1 0 FAM92 protein V_ATPase_I PF01496.14 EWC44673.1 - 0.31 8.8 1.0 0.43 8.3 0.7 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RNA_pol_3_Rpc31 PF11705.3 EWC44673.1 - 0.93 9.3 8.6 2 8.2 4.3 2.3 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 Latarcin PF10279.4 EWC44673.1 - 4.4 7.5 7.6 0.7 10.1 1.2 2.6 3 0 0 3 3 3 0 Latarcin precursor MFS_1 PF07690.11 EWC44674.1 - 6.8e-47 159.8 46.2 6.8e-47 159.8 32.0 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EWC44674.1 - 4.1e-17 61.9 31.3 8.1e-17 60.9 4.9 2.4 2 1 0 2 2 2 2 Sugar (and other) transporter TRI12 PF06609.8 EWC44674.1 - 1.3e-11 43.4 16.5 1.8e-11 42.9 11.4 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF3425 PF11905.3 EWC44675.1 - 4.3e-23 81.7 2.8 7.9e-23 80.8 1.9 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) bZIP_1 PF00170.16 EWC44675.1 - 0.0055 16.6 5.4 0.0091 15.9 3.8 1.3 1 0 0 1 1 1 1 bZIP transcription factor BMFP PF04380.8 EWC44675.1 - 0.11 12.6 1.6 0.54 10.4 0.5 2.2 2 0 0 2 2 2 0 Membrane fusogenic activity Sarcoglycan_1 PF04790.8 EWC44676.1 - 4.2 6.4 10.5 1.2 8.2 4.7 1.8 1 1 2 3 3 3 0 Sarcoglycan complex subunit protein WD40 PF00400.27 EWC44677.1 - 1.1e-39 132.8 4.5 1.4e-09 37.4 0.1 7.3 7 1 0 7 7 7 5 WD domain, G-beta repeat Nup160 PF11715.3 EWC44677.1 - 0.00079 17.6 0.1 0.049 11.7 0.0 2.8 1 1 1 3 3 3 1 Nucleoporin Nup120/160 Coatomer_WDAD PF04053.9 EWC44677.1 - 0.04 12.6 0.0 0.14 10.9 0.0 1.8 1 1 0 1 1 1 0 Coatomer WD associated region WD40 PF00400.27 EWC44678.1 - 5.7e-06 26.0 5.3 21 5.1 0.0 8.5 10 0 0 10 10 10 1 WD domain, G-beta repeat PQQ_2 PF13360.1 EWC44678.1 - 0.0011 18.5 0.0 0.57 9.6 0.0 2.8 2 0 0 2 2 2 2 PQQ-like domain PQQ PF01011.16 EWC44678.1 - 0.019 14.4 0.0 0.067 12.7 0.0 1.9 1 0 0 1 1 1 0 PQQ enzyme repeat PQQ_3 PF13570.1 EWC44678.1 - 0.034 14.4 2.6 3.4 8.0 0.0 4.1 4 0 0 4 4 4 0 PQQ-like domain DUF1583 PF07622.6 EWC44679.1 - 0.12 10.8 0.0 0.16 10.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1583) SARA PF11409.3 EWC44679.1 - 0.46 10.4 0.0 0.46 10.4 0.0 3.2 3 1 0 3 3 3 0 Smad anchor for receptor activation (SARA) DUF898 PF05987.8 EWC44680.1 - 0.0055 15.6 0.8 0.0066 15.3 0.6 1.0 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF898) DUF4328 PF14219.1 EWC44680.1 - 0.042 13.1 2.0 0.046 13.0 0.8 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4328) SOXp PF12336.3 EWC44680.1 - 0.05 14.2 0.1 0.09 13.3 0.1 1.3 1 0 0 1 1 1 0 SOX transcription factor FtsX PF02687.16 EWC44680.1 - 0.05 13.3 2.1 0.052 13.3 0.2 1.7 2 0 0 2 2 2 0 FtsX-like permease family Orai-1 PF07856.7 EWC44680.1 - 0.059 12.9 4.5 0.21 11.1 3.1 1.7 1 1 0 1 1 1 0 Mediator of CRAC channel activity Iso_dh PF00180.15 EWC44681.1 - 8.3e-96 320.9 0.0 5.5e-95 318.2 0.0 1.8 1 1 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Daxx PF03344.10 EWC44682.1 - 0.019 13.4 27.1 0.026 13.0 18.8 1.1 1 0 0 1 1 1 0 Daxx Family DUF4400 PF14348.1 EWC44682.1 - 0.12 11.6 1.8 0.19 11.0 1.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4400) PigN PF04987.9 EWC44682.1 - 0.13 10.8 0.0 0.19 10.3 0.0 1.2 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) SDA1 PF05285.7 EWC44682.1 - 0.84 8.8 35.0 1.3 8.2 24.3 1.3 1 0 0 1 1 1 0 SDA1 Hid1 PF12722.2 EWC44682.1 - 4 4.9 10.2 4.7 4.7 7.1 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein YqfQ PF14181.1 EWC44682.1 - 9.1 6.2 12.8 20 5.2 8.9 1.5 1 0 0 1 1 1 0 YqfQ-like protein BTB PF00651.26 EWC44683.1 - 1.2e-19 70.3 0.0 1.8e-19 69.7 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain BTB_2 PF02214.17 EWC44683.1 - 0.0093 16.1 0.0 0.016 15.3 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.26 EWC44684.1 - 4.5e-15 55.5 0.0 8.8e-15 54.6 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.26 EWC44685.1 - 3.7e-09 36.5 0.3 2e-08 34.1 0.1 2.2 2 1 0 2 2 2 1 BTB/POZ domain Baculo_ME53 PF06061.6 EWC44685.1 - 0.021 13.8 0.4 0.033 13.2 0.3 1.3 1 0 0 1 1 1 0 Baculoviridae ME53 DNA_RNApol_7kD PF03604.8 EWC44685.1 - 0.83 9.1 5.7 1.9 8.0 3.9 1.6 1 0 0 1 1 1 0 DNA directed RNA polymerase, 7 kDa subunit WD40 PF00400.27 EWC44686.1 - 6.5e-20 70.2 10.7 1.4e-07 31.1 0.1 7.8 7 0 0 7 7 7 5 WD domain, G-beta repeat XPG_N PF00752.12 EWC44687.1 - 3.6e-31 107.4 0.0 9.4e-31 106.0 0.0 1.8 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.13 EWC44687.1 - 5.3e-25 87.3 0.0 1.5e-24 85.8 0.0 1.9 1 0 0 1 1 1 1 XPG I-region 5_3_exonuc PF01367.15 EWC44687.1 - 0.0047 17.1 0.1 0.054 13.7 0.0 2.7 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold UIM PF02809.15 EWC44687.1 - 1.6 8.4 29.5 0.034 13.7 0.9 4.9 5 0 0 5 5 5 0 Ubiquitin interaction motif NGP1NT PF08153.7 EWC44688.1 - 3.5e-48 162.8 4.0 5.8e-48 162.1 2.8 1.4 1 0 0 1 1 1 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.18 EWC44688.1 - 8.7e-20 70.8 0.0 4.6e-16 58.8 0.0 2.4 2 0 0 2 2 2 2 50S ribosome-binding GTPase Dynamin_N PF00350.18 EWC44688.1 - 5e-06 26.4 0.3 0.12 12.1 0.0 3.6 2 2 1 3 3 3 2 Dynamin family FeoB_N PF02421.13 EWC44688.1 - 3.9e-05 22.9 0.0 0.00013 21.2 0.0 1.8 2 0 0 2 2 2 1 Ferrous iron transport protein B DUF258 PF03193.11 EWC44688.1 - 0.005 16.0 0.0 0.0094 15.1 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Arf PF00025.16 EWC44688.1 - 0.0055 15.9 0.1 0.04 13.1 0.0 2.1 2 0 0 2 2 2 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 EWC44688.1 - 0.011 15.2 0.0 6.5 6.1 0.0 3.2 2 1 0 3 3 3 0 Elongation factor Tu GTP binding domain SusD-like_3 PF14322.1 EWC44688.1 - 0.026 14.5 0.0 0.048 13.7 0.0 1.4 1 0 0 1 1 1 0 Starch-binding associating with outer membrane Peptidase_M35 PF02102.10 EWC44688.1 - 0.12 11.0 0.0 0.17 10.5 0.0 1.2 1 0 0 1 1 1 0 Deuterolysin metalloprotease (M35) family Cmc1 PF08583.5 EWC44690.1 - 2.7e-05 23.8 5.4 5.1e-05 22.9 3.7 1.4 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like RgpF PF05045.7 EWC44690.1 - 0.04 12.4 0.0 0.049 12.1 0.0 1.1 1 0 0 1 1 1 0 Rhamnan synthesis protein F Jag_N PF14804.1 EWC44690.1 - 0.097 12.6 0.2 0.17 11.8 0.1 1.4 1 0 0 1 1 1 0 Jag N-terminus Fungal_trans_2 PF11951.3 EWC44692.1 - 2e-51 174.8 0.2 2.3e-27 95.5 0.0 2.1 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.13 EWC44692.1 - 3.6e-08 33.1 6.4 7.8e-08 32.1 4.4 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Prefoldin_3 PF13758.1 EWC44693.1 - 7.4e-27 93.0 1.8 1.6e-26 91.9 0.1 2.5 2 0 0 2 2 2 1 Prefoldin subunit DUF3835 PF12927.2 EWC44693.1 - 3.3e-16 59.9 0.4 3.3e-16 59.9 0.3 5.5 4 1 1 5 5 5 1 Domain of unknown function (DUF3835) CDC45 PF02724.9 EWC44693.1 - 0.15 10.0 16.1 0.26 9.2 11.1 1.3 1 0 0 1 1 1 0 CDC45-like protein MAT1 PF06391.8 EWC44694.1 - 2.2e-47 161.2 26.1 2.8e-47 160.9 18.1 1.1 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 zf-C3HC4 PF00097.20 EWC44694.1 - 0.00031 20.3 4.1 0.00087 18.8 2.9 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 EWC44694.1 - 0.00063 19.7 5.7 0.0015 18.4 4.0 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EWC44694.1 - 0.0017 18.0 7.6 0.0083 15.8 5.6 1.9 1 1 1 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 EWC44694.1 - 0.0023 17.5 5.8 0.004 16.7 4.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EWC44694.1 - 0.0028 17.4 6.7 0.0062 16.3 4.6 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_4 PF14570.1 EWC44694.1 - 0.16 11.5 5.8 1 8.9 1.7 2.4 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-RING_UBOX PF13445.1 EWC44694.1 - 0.81 9.4 5.1 2.3 8.0 3.5 1.8 1 0 0 1 1 1 0 RING-type zinc-finger LAM_C PF12544.3 EWC44694.1 - 0.88 9.6 6.4 1.2e+02 2.7 0.0 3.3 3 0 0 3 3 3 0 Lysine-2,3-aminomutase DUF2779 PF11074.3 EWC44694.1 - 3.3 7.7 8.0 1.2 9.1 1.0 2.4 1 1 1 2 2 2 0 Domain of unknown function(DUF2779) Mur_ligase_M PF08245.7 EWC44695.1 - 1.1e-08 35.3 0.5 2.6e-07 30.8 0.3 2.7 1 1 1 2 2 2 1 Mur ligase middle domain Neural_ProG_Cyt PF06567.6 EWC44698.1 - 0.034 14.2 0.2 0.077 13.1 0.1 1.5 1 0 0 1 1 1 0 Neural chondroitin sulphate proteoglycan cytoplasmic domain TFX_C PF14601.1 EWC44699.1 - 0.16 11.8 0.0 0.24 11.1 0.0 1.2 1 0 0 1 1 1 0 DNA_binding protein, TFX, C-term PfkB PF00294.19 EWC44700.1 - 1.5e-17 63.7 2.4 5.8e-12 45.3 2.4 2.3 2 1 0 2 2 2 2 pfkB family carbohydrate kinase Methyltransf_26 PF13659.1 EWC44701.1 - 2.5e-12 46.8 0.1 4e-12 46.1 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EWC44701.1 - 1.2e-05 24.8 0.0 3.5e-05 23.2 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase small domain Inositol_P PF00459.20 EWC44702.1 - 1.2e-65 221.5 0.0 1.4e-65 221.3 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family FMO-like PF00743.14 EWC44703.1 - 1.8e-18 66.0 0.0 1.5e-16 59.6 0.0 2.0 2 0 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.1 EWC44703.1 - 2.1e-12 47.5 0.0 7.5e-12 45.7 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 EWC44703.1 - 5.2e-12 45.7 0.0 6.5e-11 42.2 0.0 2.5 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.9 EWC44703.1 - 2.5e-10 40.5 0.0 4.2e-10 39.8 0.0 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 EWC44703.1 - 3.9e-10 39.6 1.6 5.9e-10 39.0 0.0 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.1 EWC44703.1 - 4.6e-08 32.3 0.3 8.9e-07 28.1 0.0 2.7 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Amino_oxidase PF01593.19 EWC44703.1 - 0.00014 21.0 0.0 0.00028 20.0 0.0 1.4 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase Thi4 PF01946.12 EWC44703.1 - 0.00028 20.0 0.0 0.00045 19.3 0.0 1.3 1 0 0 1 1 1 1 Thi4 family DAO PF01266.19 EWC44703.1 - 0.00049 19.1 0.0 0.0031 16.4 0.0 2.1 1 1 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox PF00070.22 EWC44703.1 - 0.0032 17.8 0.8 3.3 8.1 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 EWC44703.1 - 0.008 14.6 0.2 0.013 13.9 0.1 1.3 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_3 PF01494.14 EWC44703.1 - 0.015 14.3 0.2 0.026 13.5 0.1 1.3 1 0 0 1 1 1 0 FAD binding domain AAA PF00004.24 EWC44705.1 - 4.6e-79 263.0 0.0 2.5e-39 134.4 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.9 EWC44705.1 - 7e-11 42.3 0.0 2.2e-06 27.7 0.0 2.4 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_16 PF13191.1 EWC44705.1 - 1.6e-10 41.2 0.2 0.00064 19.7 0.0 3.3 2 1 1 3 3 3 2 AAA ATPase domain RuvB_N PF05496.7 EWC44705.1 - 4.4e-10 38.9 0.0 0.0023 16.9 0.0 3.5 3 0 0 3 3 3 2 Holliday junction DNA helicase ruvB N-terminus AAA_5 PF07728.9 EWC44705.1 - 3.1e-09 36.6 0.9 0.0011 18.7 0.1 3.8 3 2 0 3 3 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 EWC44705.1 - 7.5e-09 35.8 0.5 0.00033 20.8 0.0 4.0 2 2 0 2 2 2 2 AAA domain AAA_14 PF13173.1 EWC44705.1 - 9.9e-08 31.9 0.0 0.00099 19.0 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_17 PF13207.1 EWC44705.1 - 4.3e-07 30.7 0.1 0.0052 17.5 0.0 2.8 2 1 0 2 2 2 2 AAA domain Arch_ATPase PF01637.13 EWC44705.1 - 3.5e-06 26.8 0.0 0.054 13.1 0.0 3.1 2 2 1 3 3 3 2 Archaeal ATPase IstB_IS21 PF01695.12 EWC44705.1 - 6.7e-06 25.6 0.0 0.029 13.7 0.0 2.3 2 0 0 2 2 2 2 IstB-like ATP binding protein Mg_chelatase PF01078.16 EWC44705.1 - 1.1e-05 24.6 0.5 0.083 12.0 0.1 3.1 3 0 0 3 3 3 2 Magnesium chelatase, subunit ChlI AAA_19 PF13245.1 EWC44705.1 - 2.1e-05 24.1 0.3 0.08 12.7 0.0 3.1 3 0 0 3 3 3 2 Part of AAA domain RNA_helicase PF00910.17 EWC44705.1 - 8.1e-05 22.7 0.0 0.27 11.4 0.0 2.6 2 0 0 2 2 2 2 RNA helicase Zeta_toxin PF06414.7 EWC44705.1 - 8.6e-05 21.7 0.0 0.045 12.8 0.0 2.5 2 0 0 2 2 2 1 Zeta toxin CDC48_2 PF02933.12 EWC44705.1 - 9e-05 22.0 0.0 0.0002 20.9 0.0 1.5 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 AAA_33 PF13671.1 EWC44705.1 - 0.00015 21.6 0.0 0.067 13.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain Rad17 PF03215.10 EWC44705.1 - 0.00018 20.3 0.0 0.002 16.9 0.0 2.1 2 0 0 2 2 2 1 Rad17 cell cycle checkpoint protein NACHT PF05729.7 EWC44705.1 - 0.00036 20.2 1.7 0.006 16.2 0.0 3.4 4 0 0 4 4 4 1 NACHT domain AAA_28 PF13521.1 EWC44705.1 - 0.00064 19.7 0.0 0.26 11.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.1 EWC44705.1 - 0.00067 19.2 0.7 0.057 13.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.8 EWC44705.1 - 0.0012 17.6 0.0 0.5 9.0 0.0 2.4 2 0 0 2 2 2 2 TIP49 C-terminus AAA_25 PF13481.1 EWC44705.1 - 0.0023 17.3 2.8 0.17 11.2 0.0 3.2 2 2 2 4 4 4 1 AAA domain AAA_3 PF07726.6 EWC44705.1 - 0.0043 16.6 0.0 3.1 7.4 0.0 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) UPF0079 PF02367.12 EWC44705.1 - 0.0052 16.4 0.0 0.24 11.0 0.0 2.9 3 0 0 3 3 3 1 Uncharacterised P-loop hydrolase UPF0079 Sigma54_activat PF00158.21 EWC44705.1 - 0.0071 15.8 0.0 0.18 11.2 0.0 3.0 2 2 0 2 2 2 1 Sigma-54 interaction domain Bac_DnaA PF00308.13 EWC44705.1 - 0.013 15.1 0.0 0.18 11.3 0.0 2.7 3 1 0 3 3 2 0 Bacterial dnaA protein AAA_18 PF13238.1 EWC44705.1 - 0.017 15.4 0.0 0.29 11.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.8 EWC44705.1 - 0.02 13.8 0.0 2.6 6.9 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF815) Sigma54_activ_2 PF14532.1 EWC44705.1 - 0.021 14.8 0.0 7.4 6.6 0.0 2.9 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_11 PF13086.1 EWC44705.1 - 0.028 14.0 0.0 0.9 9.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain KaiC PF06745.8 EWC44705.1 - 0.034 13.2 0.1 27 3.7 0.0 3.2 2 1 1 3 3 3 0 KaiC KAP_NTPase PF07693.9 EWC44705.1 - 0.09 11.7 0.0 0.19 10.6 0.0 1.4 1 1 0 1 1 1 0 KAP family P-loop domain AAA_30 PF13604.1 EWC44705.1 - 0.12 11.9 0.2 1.4 8.4 0.0 2.7 4 0 0 4 4 3 0 AAA domain Parvo_NS1 PF01057.12 EWC44705.1 - 0.14 10.9 0.1 2.7 6.7 0.0 2.3 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 Actin PF00022.14 EWC44706.1 - 2.6e-16 59.0 0.0 1.1e-15 57.0 0.0 1.9 2 0 0 2 2 2 1 Actin MreB_Mbl PF06723.8 EWC44706.1 - 0.0018 16.9 0.0 0.011 14.3 0.0 1.9 2 0 0 2 2 2 1 MreB/Mbl protein SBP_bac_7 PF03480.8 EWC44707.1 - 0.063 12.3 0.2 0.1 11.6 0.1 1.3 1 0 0 1 1 1 0 Bacterial extracellular solute-binding protein, family 7 PAN_4 PF14295.1 EWC44708.1 - 0.012 15.2 1.2 0.043 13.5 0.8 1.9 1 0 0 1 1 1 0 PAN domain DUF3439 PF11921.3 EWC44708.1 - 3.1 7.5 18.2 0.92 9.2 4.3 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) DUF983 PF06170.7 EWC44709.1 - 0.094 12.8 3.7 0.079 13.0 1.2 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF983) Lactonase PF10282.4 EWC44711.1 - 2.6e-59 201.0 0.0 4e-59 200.4 0.0 1.2 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller CDC45 PF02724.9 EWC44711.1 - 4.5 5.1 16.5 7.3 4.5 11.4 1.2 1 0 0 1 1 1 0 CDC45-like protein SAPS PF04499.10 EWC44711.1 - 8 4.9 12.3 13 4.3 8.5 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Acyl_transf_1 PF00698.16 EWC44715.1 - 1.8e-80 270.6 0.1 1.1e-79 268.0 0.0 2.3 3 0 0 3 3 3 1 Acyl transferase domain MaoC_dehydratas PF01575.14 EWC44715.1 - 2.4e-38 130.2 0.1 8.4e-38 128.5 0.0 2.0 2 0 0 2 2 2 1 MaoC like domain DUF1729 PF08354.5 EWC44715.1 - 1.7e-31 107.7 1.0 9.1e-31 105.4 0.2 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF1729) MaoC_dehydrat_N PF13452.1 EWC44715.1 - 3.1e-19 69.0 0.1 1.7e-18 66.6 0.0 2.3 2 0 0 2 2 2 1 N-terminal half of MaoC dehydratase FA_hydroxylase PF04116.8 EWC44715.1 - 4.9e-15 55.9 21.0 1.3e-14 54.5 14.6 1.8 1 0 0 1 1 1 1 Fatty acid hydroxylase superfamily adh_short_C2 PF13561.1 EWC44716.1 - 1.1e-20 74.4 0.0 2.8e-20 73.1 0.0 1.7 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase ketoacyl-synt PF00109.21 EWC44716.1 - 8.2e-18 64.7 0.0 1.7e-17 63.7 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain ACPS PF01648.15 EWC44716.1 - 2e-15 56.5 0.0 4.9e-15 55.3 0.0 1.6 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily Ketoacyl-synt_C PF02801.17 EWC44716.1 - 2e-12 46.9 0.0 5e-12 45.7 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain adh_short PF00106.20 EWC44716.1 - 0.00012 22.0 0.0 0.00035 20.5 0.0 1.9 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EWC44716.1 - 0.068 12.8 0.0 0.068 12.8 0.0 2.0 2 0 0 2 2 2 0 KR domain TRM PF02005.11 EWC44717.1 - 5.2e-88 295.5 0.0 1.4e-87 294.0 0.0 1.6 1 1 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase MTS PF05175.9 EWC44717.1 - 0.015 14.6 0.3 0.053 12.8 0.2 2.0 1 1 0 1 1 1 0 Methyltransferase small domain SSP160 PF06933.6 EWC44717.1 - 0.038 11.9 14.8 0.073 11.0 10.3 1.4 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Met_10 PF02475.11 EWC44717.1 - 0.055 13.0 0.0 0.13 11.8 0.0 1.5 1 0 0 1 1 1 0 Met-10+ like-protein TRM PF02005.11 EWC44718.1 - 8.2e-11 41.4 0.0 1.1e-10 41.0 0.0 1.1 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase DEAD PF00270.24 EWC44720.1 - 2e-11 43.6 0.0 3.6e-11 42.8 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EWC44720.1 - 3.1e-05 23.7 0.0 0.00016 21.4 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_25 PF13481.1 EWC44720.1 - 0.0021 17.4 0.1 0.0056 16.0 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.1 EWC44720.1 - 0.013 15.6 0.0 0.038 14.1 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.1 EWC44720.1 - 0.064 13.2 0.2 0.31 11.0 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain AAA PF00004.24 EWC44720.1 - 0.094 12.9 0.5 1.7 8.8 0.4 2.5 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PhoH PF02562.11 EWC44720.1 - 0.11 11.7 0.0 0.18 11.0 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein ODAM PF15424.1 EWC44721.1 - 0.038 13.4 0.1 0.041 13.3 0.1 1.1 1 0 0 1 1 1 0 Odontogenic ameloblast-associated family Trypan_PARP PF05887.6 EWC44721.1 - 5.4 6.8 7.9 7 6.4 5.4 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) DUF2985 PF11204.3 EWC44722.1 - 1.1e-28 98.8 4.2 2.2e-28 97.8 2.9 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2985) Troponin-I_N PF11636.3 EWC44722.1 - 0.0099 15.5 5.0 0.0099 15.5 3.5 3.7 3 1 0 3 3 3 1 Troponin I residues 1-32 Glyoxalase_2 PF12681.2 EWC44723.1 - 7.4e-13 49.0 0.0 2.3e-12 47.4 0.0 1.8 1 1 0 1 1 1 1 Glyoxalase-like domain Glyoxalase PF00903.20 EWC44723.1 - 2.7e-09 37.0 0.0 2e-08 34.2 0.0 2.3 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.1 EWC44723.1 - 0.00033 20.6 0.0 0.0009 19.2 0.0 1.8 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily NmrA PF05368.8 EWC44725.1 - 6.2e-18 64.8 0.0 9e-18 64.3 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 EWC44725.1 - 3.9e-08 33.4 0.1 6e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 NADH(P)-binding Pribosyltran_N PF13793.1 EWC44726.1 - 2.9e-39 133.4 0.0 2.5e-37 127.1 0.0 2.4 2 0 0 2 2 2 2 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.1 EWC44726.1 - 1.7e-33 115.9 0.4 1.1e-24 87.1 0.1 2.2 2 0 0 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.22 EWC44726.1 - 6.4e-07 29.1 0.4 5.6e-05 22.8 0.0 2.8 3 0 0 3 3 3 1 Phosphoribosyl transferase domain Ala_racemase_N PF01168.15 EWC44727.1 - 5e-39 134.1 0.4 7.1e-39 133.6 0.2 1.3 1 1 0 1 1 1 1 Alanine racemase, N-terminal domain eIF-4B PF06273.6 EWC44727.1 - 0.045 12.5 0.0 0.066 11.9 0.0 1.2 1 0 0 1 1 1 0 Plant specific eukaryotic initiation factor 4B HrpB1_HrpK PF09613.5 EWC44727.1 - 0.077 12.4 0.7 1.7 8.1 0.0 2.2 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB1_HrpK) Macro_2 PF14519.1 EWC44727.1 - 0.16 11.0 0.0 0.22 10.6 0.0 1.2 1 0 0 1 1 1 0 Macro-like domain Actin PF00022.14 EWC44728.1 - 1.3e-49 168.6 0.0 7.6e-31 106.9 0.0 2.2 2 0 0 2 2 2 2 Actin DASH_Dad4 PF08650.5 EWC44729.1 - 1.7e-22 79.0 2.2 1.9e-22 78.9 1.5 1.0 1 0 0 1 1 1 1 DASH complex subunit Dad4 DUF4315 PF14193.1 EWC44729.1 - 0.049 13.5 0.0 0.075 12.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4315) DASH_Dad1 PF08649.5 EWC44729.1 - 0.066 12.9 2.1 0.057 13.1 1.0 1.3 1 1 0 1 1 1 0 DASH complex subunit Dad1 SurA_N_2 PF13623.1 EWC44729.1 - 0.097 12.6 0.1 0.11 12.4 0.1 1.0 1 0 0 1 1 1 0 SurA N-terminal domain IncA PF04156.9 EWC44729.1 - 0.14 11.7 0.3 0.14 11.6 0.2 1.1 1 0 0 1 1 1 0 IncA protein zf-C2H2 PF00096.21 EWC44730.1 - 4.6e-05 23.5 24.0 0.072 13.4 0.1 4.9 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EWC44730.1 - 8.1e-05 22.6 11.6 0.29 11.5 0.6 4.1 3 1 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.1 EWC44730.1 - 0.41 10.6 0.2 0.41 10.6 0.1 3.5 4 0 0 4 4 4 0 C2H2-type zinc finger RNA_POL_M_15KD PF02150.11 EWC44730.1 - 1.7 8.3 7.7 10 5.8 0.2 3.9 4 0 0 4 4 4 0 RNA polymerases M/15 Kd subunit His_Phos_2 PF00328.17 EWC44731.1 - 7.1e-112 374.1 0.0 9.3e-112 373.7 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) RimK PF08443.6 EWC44731.1 - 0.00033 20.1 0.0 0.00058 19.3 0.0 1.3 1 0 0 1 1 1 1 RimK-like ATP-grasp domain Utp21 PF04192.7 EWC44732.1 - 4.1e-73 245.3 0.1 5.7e-73 244.9 0.1 1.2 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain WD40 PF00400.27 EWC44732.1 - 9.5e-29 98.2 25.3 4.2e-06 26.4 0.4 8.8 8 0 0 8 8 8 8 WD domain, G-beta repeat Utp12 PF04003.7 EWC44732.1 - 0.0023 17.7 0.0 0.0043 16.9 0.0 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family Nucleoporin_N PF08801.6 EWC44732.1 - 0.0072 15.1 1.0 0.58 8.8 0.0 3.7 2 2 1 4 4 4 1 Nup133 N terminal like eIF2A PF08662.6 EWC44732.1 - 0.016 14.8 0.0 0.13 11.9 0.0 2.5 3 0 0 3 3 3 0 Eukaryotic translation initiation factor eIF2A VGCC_alpha2 PF08473.6 EWC44733.1 - 0.0085 15.8 0.0 0.028 14.1 0.0 1.8 2 0 0 2 2 2 1 Neuronal voltage-dependent calcium channel alpha 2acd Ras PF00071.17 EWC44734.1 - 1.1e-65 219.9 0.0 1.3e-65 219.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EWC44734.1 - 1.6e-19 70.5 0.0 2.2e-19 70.0 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EWC44734.1 - 3.9e-13 49.0 0.1 4.8e-13 48.7 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 EWC44734.1 - 1.5e-06 27.8 0.1 5.2e-06 26.0 0.0 1.8 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 EWC44734.1 - 3.8e-06 26.2 0.0 4.3e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 EWC44734.1 - 0.0035 17.2 0.0 0.0052 16.7 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 EWC44734.1 - 0.06 12.6 0.0 0.24 10.6 0.0 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_29 PF13555.1 EWC44734.1 - 0.089 12.3 0.0 0.29 10.7 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA PF00004.24 EWC44734.1 - 0.09 12.9 0.0 12 6.1 0.0 2.4 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) G-alpha PF00503.15 EWC44734.1 - 0.11 11.1 0.6 8.3 4.9 0.1 2.6 1 1 1 2 2 2 0 G-protein alpha subunit AAA_22 PF13401.1 EWC44734.1 - 0.14 12.3 0.0 0.31 11.1 0.0 1.7 1 1 0 1 1 1 0 AAA domain Homeobox PF00046.24 EWC44734.1 - 0.41 10.3 1.7 22 4.7 1.5 2.3 2 0 0 2 2 2 0 Homeobox domain AAA PF00004.24 EWC44735.1 - 2.1e-44 150.9 0.1 8.8e-43 145.6 0.0 3.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) GRIP PF01465.15 EWC44735.1 - 3.7e-12 45.5 0.5 8e-12 44.4 0.4 1.6 1 0 0 1 1 1 1 GRIP domain AAA_5 PF07728.9 EWC44735.1 - 1e-07 31.7 0.0 7.1e-07 29.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 EWC44735.1 - 7.9e-05 22.7 0.0 7.9e-05 22.7 0.0 4.9 2 1 2 4 4 4 1 AAA ATPase domain AAA_19 PF13245.1 EWC44735.1 - 0.00044 19.9 0.4 0.0018 18.0 0.0 2.2 2 0 0 2 2 2 1 Part of AAA domain AAA_33 PF13671.1 EWC44735.1 - 0.00064 19.6 1.8 0.018 14.8 0.0 3.8 3 0 0 3 3 3 1 AAA domain AAA_17 PF13207.1 EWC44735.1 - 0.0011 19.7 0.0 0.0011 19.7 0.0 3.7 4 1 0 4 4 4 1 AAA domain AAA_22 PF13401.1 EWC44735.1 - 0.002 18.2 0.1 0.002 18.2 0.0 4.9 4 3 2 6 6 6 1 AAA domain AAA_3 PF07726.6 EWC44735.1 - 0.013 15.1 0.0 0.044 13.3 0.0 1.9 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Glyco_hydro_7 PF00840.15 EWC44736.1 - 4e-115 384.6 19.6 1.2e-113 379.7 13.6 2.4 1 1 0 1 1 1 1 Glycosyl hydrolase family 7 DUF1887 PF09002.6 EWC44737.1 - 0.045 12.1 0.2 0.073 11.4 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1887) NmrA PF05368.8 EWC44738.1 - 1e-25 90.3 0.0 1.1e-25 90.2 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 EWC44738.1 - 1.2e-10 41.7 0.5 5.9e-10 39.4 0.0 1.9 1 1 0 2 2 2 1 NADH(P)-binding Saccharop_dh PF03435.13 EWC44738.1 - 0.00026 20.0 0.0 0.00038 19.5 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase Epimerase PF01370.16 EWC44738.1 - 0.0013 18.2 0.1 0.0073 15.7 0.0 2.0 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.19 EWC44738.1 - 0.013 15.8 0.0 0.027 14.7 0.0 1.6 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain GCIP PF13324.1 EWC44739.1 - 4.3e-06 26.1 0.1 0.019 14.1 0.0 2.5 2 0 0 2 2 2 2 Grap2 and cyclin-D-interacting Acetyltransf_3 PF13302.1 EWC44740.1 - 5.6e-10 39.5 0.0 8.1e-10 39.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain MS_channel PF00924.13 EWC44741.1 - 8.6e-23 80.7 1.0 1.5e-22 79.9 0.7 1.4 1 0 0 1 1 1 1 Mechanosensitive ion channel EF-hand_1 PF00036.27 EWC44741.1 - 0.0019 17.3 0.2 0.0048 16.1 0.1 1.7 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.1 EWC44741.1 - 0.0037 17.0 0.0 0.015 15.1 0.0 2.0 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.1 EWC44741.1 - 0.048 13.8 0.2 0.12 12.5 0.2 1.6 1 0 0 1 1 1 0 EF-hand domain pair DUF3987 PF13148.1 EWC44741.1 - 0.091 11.3 1.1 0.15 10.5 0.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) Nic96 PF04097.9 EWC44742.1 - 3.6e-191 636.4 0.0 4.5e-191 636.1 0.0 1.1 1 0 0 1 1 1 1 Nup93/Nic96 Anoctamin PF04547.7 EWC44744.1 - 4.2e-119 398.1 9.7 5.2e-119 397.8 6.7 1.0 1 0 0 1 1 1 1 Calcium-activated chloride channel FA_desaturase PF00487.19 EWC44744.1 - 1.4 8.2 5.1 7 6.0 1.5 2.5 2 0 0 2 2 2 0 Fatty acid desaturase Cation_efflux PF01545.16 EWC44745.1 - 3e-71 239.8 4.8 3.4e-71 239.6 3.3 1.0 1 0 0 1 1 1 1 Cation efflux family SHR3_chaperone PF08229.6 EWC44745.1 - 0.11 11.4 0.5 0.25 10.2 0.0 1.8 2 0 0 2 2 2 0 ER membrane protein SH3 7tm_7 PF08395.7 EWC44745.1 - 0.17 10.8 2.9 2.1 7.2 0.4 2.4 2 1 1 3 3 3 0 7tm Chemosensory receptor MerC PF03203.9 EWC44745.1 - 0.6 10.4 4.7 0.3 11.4 0.4 2.4 2 1 1 3 3 3 0 MerC mercury resistance protein Pkinase PF00069.20 EWC44746.1 - 1.7e-42 145.3 0.1 6.3e-25 87.8 0.0 2.8 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 EWC44746.1 - 1.1e-13 50.8 0.1 6.9e-10 38.4 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Na_Ca_ex PF01699.19 EWC44747.1 - 6.9e-22 77.5 31.0 2.1e-12 46.8 6.2 3.6 2 1 1 3 3 3 2 Sodium/calcium exchanger protein DUF307 PF03733.8 EWC44747.1 - 6.4e-12 45.7 3.3 6.4e-12 45.7 2.3 4.1 5 0 0 5 5 5 1 Domain of unknown function (DUF307) DUF2296 PF10058.4 EWC44749.1 - 1e-20 73.2 0.3 1.7e-20 72.5 0.2 1.4 1 0 0 1 1 1 1 Predicted integral membrane metal-binding protein (DUF2296) DUF605 PF04652.11 EWC44749.1 - 4.8 6.4 18.5 1.8 7.8 9.6 2.0 2 0 0 2 2 2 0 Vta1 like Adaptin_N PF01602.15 EWC44750.1 - 5.5e-125 417.6 4.6 6.7e-125 417.3 3.2 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptin_C PF02296.11 EWC44750.1 - 1.7e-44 150.3 0.0 4.1e-44 149.1 0.0 1.7 1 0 0 1 1 1 1 Alpha adaptin AP2, C-terminal domain Alpha_adaptinC2 PF02883.15 EWC44750.1 - 6.4e-18 65.1 2.0 7.2e-18 64.9 0.6 1.7 2 0 0 2 2 2 1 Adaptin C-terminal domain bZIP_1 PF00170.16 EWC44751.1 - 9e-08 31.9 12.7 5.5e-07 29.4 8.8 2.1 1 1 0 1 1 1 1 bZIP transcription factor HALZ PF02183.13 EWC44751.1 - 0.0045 16.6 0.9 0.0045 16.6 0.6 1.8 2 0 0 2 2 2 1 Homeobox associated leucine zipper DUF2205 PF10224.4 EWC44751.1 - 0.011 15.3 2.0 0.02 14.4 1.4 1.4 1 0 0 1 1 1 0 Predicted coiled-coil protein (DUF2205) bZIP_2 PF07716.10 EWC44751.1 - 0.12 12.2 17.0 0.11 12.3 1.6 2.6 1 1 1 2 2 2 0 Basic region leucine zipper NCA2 PF08637.5 EWC44752.1 - 2.6e-84 282.5 0.0 3.7e-84 282.0 0.0 1.2 1 0 0 1 1 1 1 ATP synthase regulation protein NCA2 DAO PF01266.19 EWC44753.1 - 4.1e-20 72.0 2.1 4.1e-18 65.4 1.5 2.4 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EWC44753.1 - 0.0019 18.1 0.1 0.0045 16.9 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.22 EWC44753.1 - 0.07 13.5 0.0 0.45 10.9 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 EWC44753.1 - 0.13 11.3 0.0 0.21 10.6 0.0 1.3 1 0 0 1 1 1 0 Thi4 family YL1_C PF08265.6 EWC44754.1 - 6.5e-15 54.3 0.1 1.4e-14 53.2 0.0 1.6 2 0 0 2 2 2 1 YL1 nuclear protein C-terminal domain Brr6_like_C_C PF10104.4 EWC44755.1 - 7e-44 148.6 1.8 8.8e-44 148.3 1.3 1.1 1 0 0 1 1 1 1 Di-sulfide bridge nucleocytoplasmic transport domain TYA PF01021.14 EWC44755.1 - 0.039 14.1 1.6 0.094 12.9 1.1 1.6 1 0 0 1 1 1 0 TYA transposon protein ARL6IP6 PF15062.1 EWC44755.1 - 0.42 10.5 1.7 8.3 6.3 0.0 3.1 3 0 0 3 3 3 0 Haemopoietic lineage transmembrane helix COX4_pro_2 PF07835.7 EWC44756.1 - 0.0034 17.3 2.0 0.0052 16.7 1.4 1.2 1 0 0 1 1 1 1 Bacterial aa3 type cytochrome c oxidase subunit IV HemY_N PF07219.8 EWC44756.1 - 0.1 12.1 0.5 0.39 10.2 0.1 1.9 2 0 0 2 2 2 0 HemY protein N-terminus Y_phosphatase PF00102.22 EWC44757.1 - 3.7e-64 216.2 1.7 1.4e-62 211.1 1.2 2.8 1 1 0 1 1 1 1 Protein-tyrosine phosphatase Rhodanese PF00581.15 EWC44757.1 - 1.5e-10 41.3 0.0 1.9e-09 37.8 0.0 2.3 2 0 0 2 2 2 1 Rhodanese-like domain Y_phosphatase3 PF13350.1 EWC44757.1 - 0.0047 17.1 0.0 0.014 15.6 0.0 1.8 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.15 EWC44757.1 - 0.0049 16.4 0.6 0.013 15.0 0.2 1.8 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain DUF3720 PF12517.3 EWC44757.1 - 0.073 13.7 0.2 0.18 12.5 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3720) DUF3567 PF12091.3 EWC44760.1 - 0.063 13.2 0.0 0.073 13.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3567) COX16 PF14138.1 EWC44761.1 - 2.8e-30 104.2 0.1 3.9e-30 103.8 0.1 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein COX16 OppC_N PF12911.2 EWC44761.1 - 0.014 14.7 0.0 0.023 14.0 0.0 1.3 1 0 0 1 1 1 0 N-terminal TM domain of oligopeptide transport permease C Galactosyl_T PF01762.16 EWC44761.1 - 0.12 11.9 0.4 0.17 11.4 0.2 1.1 1 0 0 1 1 1 0 Galactosyltransferase Pterin_4a PF01329.14 EWC44762.1 - 9.9e-09 34.8 0.0 2.7e-08 33.4 0.0 1.7 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase FGGY_C PF02782.11 EWC44763.1 - 4.8e-49 166.6 0.5 7e-49 166.1 0.3 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.16 EWC44763.1 - 3.6e-21 75.6 0.1 9.3e-18 64.4 0.0 2.5 2 1 0 2 2 2 2 FGGY family of carbohydrate kinases, N-terminal domain BcrAD_BadFG PF01869.15 EWC44763.1 - 0.017 14.4 0.1 0.48 9.6 0.0 2.4 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family RHH_1 PF01402.16 EWC44763.1 - 0.018 14.8 0.0 0.05 13.5 0.0 1.8 1 0 0 1 1 1 0 Ribbon-helix-helix protein, copG family Rep-A_N PF04057.7 EWC44764.1 - 0.025 14.3 0.0 0.064 13.0 0.0 1.7 1 1 0 1 1 1 0 Replication factor-A protein 1, N-terminal domain Cellulase PF00150.13 EWC44765.1 - 2.4e-20 72.9 0.2 4.5e-20 72.0 0.1 1.4 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Ricin_B_lectin PF00652.17 EWC44765.1 - 1.1e-16 61.0 0.0 1.9e-16 60.1 0.0 1.4 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain RicinB_lectin_2 PF14200.1 EWC44765.1 - 3e-08 33.9 0.0 0.00055 20.2 0.0 3.1 3 0 0 3 3 3 2 Ricin-type beta-trefoil lectin domain-like Glyco_hydro_42 PF02449.10 EWC44765.1 - 2.1e-06 27.1 0.0 3.5e-05 23.1 0.0 2.1 2 0 0 2 2 2 1 Beta-galactosidase Glyco_hydro_35 PF01301.14 EWC44765.1 - 0.0081 15.5 0.1 0.013 14.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 Glyco_hydro_1 PF00232.13 EWC44765.1 - 0.033 12.3 0.0 0.053 11.7 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 1 Glyco_hydro_53 PF07745.8 EWC44765.1 - 0.091 11.5 0.2 1.7 7.3 0.1 2.1 2 0 0 2 2 2 0 Glycosyl hydrolase family 53 MFS_1 PF07690.11 EWC44770.1 - 1.8e-48 165.0 28.3 3e-48 164.3 19.6 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EWC44770.1 - 1.2e-13 50.4 6.7 1.2e-13 50.4 4.6 1.8 2 0 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.8 EWC44770.1 - 1e-06 27.2 2.3 1.3e-06 26.9 1.6 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) BT1 PF03092.11 EWC44770.1 - 0.0013 17.4 2.2 0.049 12.3 0.0 2.2 2 0 0 2 2 2 2 BT1 family SH3_2 PF07653.12 EWC44771.1 - 0.18 11.2 1.1 1.7 8.1 0.4 2.3 2 0 0 2 2 2 0 Variant SH3 domain Maelstrom PF13017.1 EWC44773.1 - 0.02 14.4 0.1 0.062 12.7 0.0 1.8 2 0 0 2 2 2 0 piRNA pathway germ-plasm component HA2 PF04408.18 EWC44774.1 - 9e-19 67.3 0.6 3.8e-18 65.3 0.0 2.4 3 0 0 3 3 3 1 Helicase associated domain (HA2) Helicase_C PF00271.26 EWC44774.1 - 2.4e-13 49.7 0.0 2.5e-12 46.4 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.24 EWC44774.1 - 1.3e-10 41.0 0.0 3.6e-10 39.5 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 EWC44774.1 - 1.9e-09 37.7 0.3 1.4e-08 34.9 0.1 2.4 2 0 0 2 2 2 1 AAA domain OB_NTP_bind PF07717.11 EWC44774.1 - 0.0015 18.3 0.0 0.0042 16.8 0.0 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold KaiC PF06745.8 EWC44774.1 - 0.006 15.7 0.0 0.014 14.4 0.0 1.6 1 0 0 1 1 1 1 KaiC T2SE PF00437.15 EWC44774.1 - 0.02 13.8 0.0 0.038 12.9 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_29 PF13555.1 EWC44774.1 - 0.022 14.2 0.0 0.091 12.3 0.0 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_10 PF12846.2 EWC44774.1 - 0.047 13.1 0.0 0.15 11.4 0.0 1.9 1 1 0 1 1 1 0 AAA-like domain Arch_ATPase PF01637.13 EWC44774.1 - 0.053 13.2 0.1 0.23 11.1 0.0 2.1 2 0 0 2 2 2 0 Archaeal ATPase AAA_23 PF13476.1 EWC44774.1 - 0.056 13.7 0.1 0.39 11.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain DHquinase_I PF01487.10 EWC44775.1 - 2.6e-55 187.5 0.0 4.5e-55 186.7 0.0 1.4 1 0 0 1 1 1 1 Type I 3-dehydroquinase AP_endonuc_2 PF01261.19 EWC44775.1 - 2.7e-29 102.0 0.0 6.4e-28 97.5 0.0 2.8 3 0 0 3 3 3 1 Xylose isomerase-like TIM barrel Glyoxalase_5 PF14696.1 EWC44775.1 - 2.8e-24 85.6 0.0 8.8e-24 84.0 0.0 1.8 2 0 0 2 2 2 1 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal Glyoxalase PF00903.20 EWC44775.1 - 1.8e-07 31.1 0.0 0.0076 16.2 0.0 2.6 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.1 EWC44775.1 - 7.5e-05 22.7 0.0 0.25 11.3 0.0 2.6 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.2 EWC44775.1 - 0.0018 18.8 0.0 0.2 12.2 0.0 2.8 2 0 0 2 2 2 1 Glyoxalase-like domain Fungal_trans PF04082.13 EWC44776.1 - 6.5e-28 97.3 0.0 1.1e-27 96.5 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EWC44776.1 - 2.1e-05 24.3 19.2 5.4e-05 23.0 13.3 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Flavin_Reduct PF01613.13 EWC44777.1 - 1.3e-10 41.3 0.0 1.6e-10 41.0 0.0 1.1 1 0 0 1 1 1 1 Flavin reductase like domain DUF607 PF04678.8 EWC44778.1 - 2.5e-37 128.5 0.0 6.8e-37 127.1 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function, DUF607 Mg-por_mtran_C PF07109.6 EWC44779.1 - 0.077 13.0 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Magnesium-protoporphyrin IX methyltransferase C-terminus Sigma70_ner PF04546.8 EWC44780.1 - 0.099 12.2 5.6 0.17 11.5 3.9 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region Glucos_trans_II PF14264.1 EWC44780.1 - 0.12 11.3 0.0 0.18 10.7 0.0 1.2 1 0 0 1 1 1 0 Glucosyl transferase GtrII DUF2937 PF11157.3 EWC44780.1 - 0.22 10.8 2.0 0.63 9.3 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2937) Herpes_LMP2 PF07415.6 EWC44780.1 - 0.26 9.8 2.1 0.96 7.9 0.0 2.2 2 0 0 2 2 2 0 Gammaherpesvirus latent membrane protein (LMP2) protein MFS_1 PF07690.11 EWC44781.1 - 1.3e-27 96.4 55.5 1.1e-25 90.0 21.9 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EWC44781.1 - 5.5e-07 28.5 6.2 5.5e-07 28.5 4.3 1.9 2 0 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.8 EWC44781.1 - 0.018 13.2 3.4 0.11 10.6 0.9 2.2 2 0 0 2 2 2 0 Fungal trichothecene efflux pump (TRI12) DnaJ PF00226.26 EWC44782.1 - 1.1e-21 76.2 1.6 1.1e-21 76.2 1.1 2.1 2 0 0 2 2 2 1 DnaJ domain NPR3 PF03666.8 EWC44782.1 - 0.004 15.7 3.9 0.0057 15.2 2.7 1.2 1 0 0 1 1 1 1 Nitrogen Permease regulator of amino acid transport activity 3 ECM11 PF15463.1 EWC44782.1 - 0.13 12.4 0.5 0.13 12.4 0.3 2.8 3 0 0 3 3 3 0 Extracellular mutant protein 11 MMR_HSR1 PF01926.18 EWC44783.1 - 1.2e-18 67.1 0.0 1.7e-18 66.6 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 EWC44783.1 - 1e-06 28.1 0.0 1.4e-06 27.6 0.0 1.2 1 0 0 1 1 1 1 Ferrous iron transport protein B SRPRB PF09439.5 EWC44783.1 - 1.4e-05 24.3 0.0 2.7e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.22 EWC44783.1 - 2.3e-05 23.9 0.0 0.00047 19.6 0.0 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AIG1 PF04548.11 EWC44783.1 - 0.00022 20.3 0.0 0.12 11.5 0.0 2.1 2 0 0 2 2 2 2 AIG1 family DUF258 PF03193.11 EWC44783.1 - 0.00085 18.5 0.1 0.0021 17.2 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function, DUF258 Dynamin_N PF00350.18 EWC44783.1 - 0.0012 18.6 0.0 0.053 13.3 0.1 2.2 1 1 1 2 2 2 1 Dynamin family FA_synthesis PF02504.10 EWC44783.1 - 0.0072 15.2 0.0 0.011 14.6 0.0 1.1 1 0 0 1 1 1 1 Fatty acid synthesis protein Septin PF00735.13 EWC44783.1 - 0.12 11.4 0.0 1.4 7.8 0.0 2.4 1 1 0 1 1 1 0 Septin IIGP PF05049.8 EWC44783.1 - 0.12 11.2 0.0 0.16 10.7 0.0 1.1 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) Miro PF08477.8 EWC44783.1 - 0.13 12.7 0.0 0.26 11.7 0.0 1.6 1 1 0 1 1 1 0 Miro-like protein AAA_29 PF13555.1 EWC44783.1 - 0.14 11.6 0.0 0.27 10.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Mito_fiss_reg PF05308.6 EWC44783.1 - 1.5 8.1 5.9 2.3 7.5 4.1 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator Sec63 PF02889.11 EWC44784.1 - 1.5e-51 175.4 0.0 2.2e-51 174.9 0.0 1.2 1 0 0 1 1 1 1 Sec63 Brl domain DEAD PF00270.24 EWC44784.1 - 3.6e-25 88.3 0.0 9.7e-25 87.0 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 EWC44784.1 - 2.8e-09 37.0 0.0 5.5e-09 36.1 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.26 EWC44784.1 - 1e-07 31.6 0.0 2.6e-07 30.4 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_30 PF13604.1 EWC44784.1 - 0.01 15.4 0.0 0.017 14.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain UvrD-helicase PF00580.16 EWC44784.1 - 0.014 14.7 0.0 0.027 13.7 0.0 1.4 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain AAA_22 PF13401.1 EWC44784.1 - 0.038 14.1 0.0 0.083 13.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain HHH_5 PF14520.1 EWC44784.1 - 0.056 13.6 0.0 0.21 11.8 0.0 2.0 1 0 0 1 1 1 0 Helix-hairpin-helix domain Na_Ca_ex PF01699.19 EWC44785.1 - 2e-45 153.8 36.9 1.2e-23 83.2 7.1 3.0 3 0 0 3 3 3 2 Sodium/calcium exchanger protein Nuc_sug_transp PF04142.10 EWC44786.1 - 4.4e-90 301.0 10.7 6.4e-90 300.5 7.4 1.2 1 0 0 1 1 1 1 Nucleotide-sugar transporter UAA PF08449.6 EWC44786.1 - 2.2e-11 43.2 10.3 3e-11 42.8 7.2 1.3 1 0 0 1 1 1 1 UAA transporter family EmrE PF13536.1 EWC44786.1 - 1.3e-07 31.8 1.3 1.3e-07 31.8 0.9 2.6 2 0 0 2 2 2 1 Multidrug resistance efflux transporter EamA PF00892.15 EWC44786.1 - 4.2e-05 23.5 2.3 4.2e-05 23.5 1.6 3.2 2 1 0 2 2 2 1 EamA-like transporter family TPT PF03151.11 EWC44786.1 - 8.3e-05 22.2 20.3 0.0001 22.0 0.7 2.5 2 0 0 2 2 2 2 Triose-phosphate Transporter family UPF0546 PF10639.4 EWC44786.1 - 0.45 10.3 4.5 0.37 10.6 0.1 2.4 2 0 0 2 2 2 0 Uncharacterised protein family UPF0546 TPR_MLP1_2 PF07926.7 EWC44787.1 - 1.4e-23 83.0 21.4 1.4e-23 83.0 14.8 19.5 4 3 9 15 15 15 5 TPR/MLP1/MLP2-like protein Fib_alpha PF08702.5 EWC44787.1 - 0.0067 16.5 9.9 0.0067 16.5 6.9 17.2 8 5 10 19 19 19 8 Fibrinogen alpha/beta chain family Methyltransf_23 PF13489.1 EWC44789.1 - 8.7e-20 71.0 0.0 1.3e-19 70.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EWC44789.1 - 2.3e-18 66.4 0.0 1.2e-17 64.1 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 EWC44789.1 - 4e-15 55.7 0.0 5.7e-15 55.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EWC44789.1 - 1e-14 55.0 0.0 1.6e-14 54.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EWC44789.1 - 1.9e-14 53.8 0.0 3.2e-14 53.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EWC44789.1 - 2.6e-09 37.1 0.1 5.9e-09 35.9 0.1 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EWC44789.1 - 2.6e-08 34.1 0.0 4.2e-08 33.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 EWC44789.1 - 1.4e-06 27.5 0.0 2.1e-06 27.0 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase PrmA PF06325.8 EWC44789.1 - 6.4e-06 25.5 0.0 1e-05 24.7 0.0 1.3 1 1 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Ubie_methyltran PF01209.13 EWC44789.1 - 0.00019 20.6 0.0 0.00027 20.1 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.9 EWC44789.1 - 0.00035 20.0 0.0 0.00057 19.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_9 PF08003.6 EWC44789.1 - 0.0055 15.4 0.0 0.0081 14.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) FtsJ PF01728.14 EWC44789.1 - 0.03 14.3 0.0 0.055 13.4 0.0 1.5 1 1 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_32 PF13679.1 EWC44789.1 - 0.031 13.9 0.0 0.046 13.4 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_24 PF13578.1 EWC44789.1 - 0.074 13.8 0.0 0.19 12.5 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain DUF3439 PF11921.3 EWC44789.1 - 2.6 7.8 6.9 4.6 6.9 4.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Velvet PF11754.3 EWC44790.1 - 3.5e-57 193.2 0.0 5.9e-57 192.5 0.0 1.3 1 0 0 1 1 1 1 Velvet factor MOZ_SAS PF01853.13 EWC44791.1 - 1.6e-78 262.3 0.1 2.4e-78 261.7 0.0 1.2 1 0 0 1 1 1 1 MOZ/SAS family PHD PF00628.24 EWC44791.1 - 0.00012 21.6 3.6 0.00012 21.6 2.5 2.2 2 0 0 2 2 2 1 PHD-finger C1_1 PF00130.17 EWC44791.1 - 0.045 13.4 0.4 0.045 13.4 0.2 2.6 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Zn_ribbon_recom PF13408.1 EWC44791.1 - 0.2 11.9 2.6 0.12 12.6 0.2 1.9 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain PHD_2 PF13831.1 EWC44791.1 - 1.6 8.0 4.0 5.3 6.4 2.8 1.9 1 1 0 1 1 1 0 PHD-finger SAPS PF04499.10 EWC44793.1 - 1.5e-185 617.4 0.0 1.5e-185 617.4 0.0 2.5 3 0 0 3 3 3 1 SIT4 phosphatase-associated protein Complex1_51K PF01512.12 EWC44794.1 - 2.3e-46 157.2 0.0 3.4e-46 156.7 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase 51 Kd subunit NADH_4Fe-4S PF10589.4 EWC44794.1 - 1e-16 59.7 1.1 1e-16 59.7 0.8 2.0 2 0 0 2 2 2 1 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region SLBB PF10531.4 EWC44794.1 - 1.2e-09 37.9 0.0 2.6e-09 36.8 0.0 1.6 1 0 0 1 1 1 1 SLBB domain Snf7 PF03357.16 EWC44795.1 - 2.3e-43 147.5 15.7 2.8e-43 147.2 10.9 1.0 1 0 0 1 1 1 1 Snf7 Herpes_UL6 PF01763.11 EWC44795.1 - 0.00095 17.4 3.3 0.0015 16.7 2.3 1.3 1 1 0 1 1 1 1 Herpesvirus UL6 like NPV_P10 PF05531.7 EWC44795.1 - 0.0021 18.2 5.9 0.37 11.0 1.4 2.5 2 0 0 2 2 2 2 Nucleopolyhedrovirus P10 protein Prefoldin PF02996.12 EWC44795.1 - 0.0036 16.9 11.1 0.012 15.2 0.1 3.8 1 1 2 4 4 4 1 Prefoldin subunit DUF4582 PF15189.1 EWC44795.1 - 0.0046 16.2 0.9 0.0073 15.5 0.7 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4582) Prefoldin_2 PF01920.15 EWC44795.1 - 0.018 14.8 10.0 0.046 13.4 0.0 3.4 1 1 2 3 3 3 0 Prefoldin subunit ADIP PF11559.3 EWC44795.1 - 0.032 14.1 8.8 0.15 11.9 1.9 2.1 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding FlaC_arch PF05377.6 EWC44795.1 - 0.05 13.4 3.1 8.7 6.3 0.0 2.8 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF4094 PF13334.1 EWC44795.1 - 0.061 13.7 5.3 2.2 8.7 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4094) DUF342 PF03961.8 EWC44795.1 - 0.082 11.3 9.0 0.33 9.3 6.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF342) DASH_Dam1 PF08653.5 EWC44795.1 - 0.095 12.4 5.8 15 5.4 0.1 3.7 3 1 0 3 3 3 0 DASH complex subunit Dam1 Reo_sigmaC PF04582.7 EWC44795.1 - 0.25 10.4 4.8 2.4 7.2 0.5 2.0 1 1 0 1 1 1 0 Reovirus sigma C capsid protein BLOC1_2 PF10046.4 EWC44795.1 - 0.3 11.2 11.5 0.81 9.8 3.2 2.6 1 1 2 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Tht1 PF04163.7 EWC44795.1 - 0.34 9.2 4.5 0.43 8.9 3.1 1.1 1 0 0 1 1 1 0 Tht1-like nuclear fusion protein AAA_13 PF13166.1 EWC44795.1 - 0.36 9.2 8.0 0.95 7.8 5.6 1.6 1 1 0 1 1 1 0 AAA domain IncA PF04156.9 EWC44795.1 - 0.36 10.3 3.7 3.1 7.3 2.6 2.1 1 1 0 1 1 1 0 IncA protein DUF4337 PF14235.1 EWC44795.1 - 0.38 10.5 5.6 0.16 11.7 2.0 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4337) DUF4140 PF13600.1 EWC44795.1 - 0.47 10.9 4.7 2 8.9 0.0 3.2 2 1 2 4 4 4 0 N-terminal domain of unknown function (DUF4140) TMF_TATA_bd PF12325.3 EWC44795.1 - 0.56 9.9 11.2 7.3 6.3 0.1 2.3 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding MitMem_reg PF13012.1 EWC44795.1 - 0.6 10.2 8.4 0.87 9.6 4.3 2.0 1 1 1 2 2 2 0 Maintenance of mitochondrial structure and function Mod_r PF07200.8 EWC44795.1 - 0.72 9.7 8.5 0.33 10.8 2.8 2.0 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein DUF972 PF06156.8 EWC44795.1 - 0.82 10.0 9.0 3.9 7.8 2.1 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF972) SlyX PF04102.7 EWC44795.1 - 0.87 10.0 7.6 42 4.6 4.9 3.3 1 1 1 2 2 2 0 SlyX APG6 PF04111.7 EWC44795.1 - 1.5 7.8 10.4 1.2 8.1 6.4 1.4 1 1 0 1 1 1 0 Autophagy protein Apg6 OmpH PF03938.9 EWC44795.1 - 4 7.3 12.6 22 4.9 8.5 2.0 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) GrpE PF01025.14 EWC44795.1 - 4.7 6.7 8.7 3.2 7.2 4.1 2.1 1 1 1 2 2 2 0 GrpE DUF1751 PF08551.5 EWC44796.1 - 0.026 14.8 0.4 0.026 14.8 0.3 1.7 1 1 1 2 2 2 0 Eukaryotic integral membrane protein (DUF1751) Methyltransf_6 PF03737.10 EWC44797.1 - 5.3e-17 62.0 0.2 6.4e-17 61.8 0.1 1.1 1 0 0 1 1 1 1 Demethylmenaquinone methyltransferase WD40 PF00400.27 EWC44798.1 - 7.9e-43 142.8 12.1 7e-07 28.8 0.1 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat F-box-like PF12937.2 EWC44798.1 - 7.8e-13 47.9 0.1 1.5e-12 46.9 0.1 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EWC44798.1 - 1.6e-09 37.2 0.2 3.1e-09 36.2 0.1 1.6 1 0 0 1 1 1 1 F-box domain Nup160 PF11715.3 EWC44798.1 - 0.00029 19.1 1.7 0.94 7.5 0.1 3.7 2 2 1 3 3 3 2 Nucleoporin Nup120/160 MgtE_N PF03448.12 EWC44798.1 - 0.096 13.0 0.0 0.19 12.0 0.0 1.4 1 0 0 1 1 1 0 MgtE intracellular N domain DUF3454 PF11936.3 EWC44799.1 - 0.0058 16.8 0.4 0.048 13.8 0.4 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF3454) Kelch_5 PF13854.1 EWC44800.1 - 7.2e-19 67.3 1.0 2.5e-11 43.2 0.1 4.0 4 0 0 4 4 4 3 Kelch motif Kelch_6 PF13964.1 EWC44800.1 - 2.3e-09 37.0 7.6 0.023 14.8 0.0 6.0 5 1 0 5 5 5 2 Kelch motif Kelch_3 PF13415.1 EWC44800.1 - 2.4e-09 37.1 9.7 0.00053 20.0 0.0 5.6 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_2 PF07646.10 EWC44800.1 - 5e-09 35.5 5.7 0.076 12.8 0.0 5.6 5 0 0 5 5 5 3 Kelch motif Kelch_4 PF13418.1 EWC44800.1 - 1.5e-06 27.8 7.5 0.003 17.2 0.0 5.0 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_1 PF01344.20 EWC44800.1 - 4.2e-06 26.1 0.9 0.11 12.0 0.0 4.6 4 0 0 4 4 4 1 Kelch motif Abhydrolase_2 PF02230.11 EWC44801.1 - 6.7e-32 110.6 0.0 4.2e-22 78.6 0.0 2.1 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Abhydrolase_6 PF12697.2 EWC44801.1 - 6e-05 23.0 0.3 0.00032 20.6 0.2 2.1 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EWC44801.1 - 0.00017 21.3 0.2 0.18 11.5 0.0 2.4 2 1 0 2 2 2 2 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 EWC44801.1 - 0.00093 18.4 0.0 0.0018 17.5 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family CENP-T PF15511.1 EWC44801.1 - 0.002 17.4 4.9 0.0023 17.2 3.4 1.1 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T Lin-8 PF03353.10 EWC44801.1 - 0.16 11.2 2.4 0.23 10.7 1.6 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist TFIIF_alpha PF05793.7 EWC44801.1 - 0.16 10.2 12.4 0.23 9.7 8.6 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Prothymosin PF03247.9 EWC44801.1 - 0.19 11.9 27.2 0.41 10.8 18.9 1.6 1 0 0 1 1 1 0 Prothymosin/parathymosin family Sigma70_ner PF04546.8 EWC44801.1 - 0.59 9.7 15.2 1.1 8.8 10.5 1.5 1 0 0 1 1 1 0 Sigma-70, non-essential region CDC45 PF02724.9 EWC44801.1 - 0.91 7.4 15.1 1.2 7.0 10.5 1.1 1 0 0 1 1 1 0 CDC45-like protein DNA_pol_phi PF04931.8 EWC44801.1 - 2.2 5.9 21.8 2.7 5.6 15.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi Nop14 PF04147.7 EWC44801.1 - 5 4.9 26.5 6.7 4.5 18.4 1.1 1 0 0 1 1 1 0 Nop14-like family BUD22 PF09073.5 EWC44801.1 - 8.7 5.2 15.6 11 4.9 10.8 1.1 1 0 0 1 1 1 0 BUD22 Daxx PF03344.10 EWC44801.1 - 9.9 4.4 20.2 12 4.1 14.0 1.1 1 0 0 1 1 1 0 Daxx Family Brr6_like_C_C PF10104.4 EWC44802.1 - 0.036 13.5 6.8 0.066 12.7 0.1 2.2 2 0 0 2 2 2 0 Di-sulfide bridge nucleocytoplasmic transport domain Sporozoite_P67 PF05642.6 EWC44802.1 - 0.19 9.5 3.0 0.25 9.1 2.1 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen AA_permease_2 PF13520.1 EWC44803.1 - 6.8e-62 209.3 45.3 8.6e-62 209.0 31.4 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EWC44803.1 - 8.5e-21 73.8 40.2 1.6e-19 69.6 27.9 2.1 1 1 0 1 1 1 1 Amino acid permease GAS2 PF02187.12 EWC44804.1 - 0.00013 21.6 0.1 0.00032 20.3 0.0 1.5 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain F-box-like PF12937.2 EWC44805.1 - 1.6e-08 34.1 0.9 3.7e-08 32.9 0.6 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EWC44805.1 - 0.00079 19.0 0.3 0.0031 17.1 0.2 2.1 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 EWC44806.1 - 2.2e-05 24.1 0.0 6.3e-05 22.6 0.0 1.9 1 0 0 1 1 1 1 F-box-like E1-E2_ATPase PF00122.15 EWC44807.1 - 7.5e-18 64.4 0.0 1.6e-17 63.3 0.0 1.5 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.21 EWC44807.1 - 1.4e-11 45.1 0.0 5.7e-11 43.2 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 EWC44807.1 - 3.3e-09 37.1 0.0 8.4e-09 35.8 0.0 1.8 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 EWC44807.1 - 0.003 17.4 0.0 0.011 15.6 0.0 2.0 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 EWC44807.1 - 0.0049 16.4 0.0 0.0095 15.5 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase ATP-synt_8 PF00895.15 EWC44807.1 - 9.4 6.5 7.5 13 6.0 1.4 2.9 2 0 0 2 2 2 0 ATP synthase protein 8 CR6_interact PF10147.4 EWC44814.1 - 0.2 10.9 1.9 1.7 7.9 0.0 2.2 1 1 1 2 2 2 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 NPV_P10 PF05531.7 EWC44815.1 - 0.47 10.7 2.3 19 5.6 0.1 2.9 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF1854 PF08909.6 EWC44817.1 - 0.095 12.3 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1854) RE_Eco47II PF09553.5 EWC44818.1 - 0.034 13.2 0.1 0.099 11.7 0.0 1.8 2 0 0 2 2 2 0 Eco47II restriction endonuclease Fungal_trans PF04082.13 EWC44821.1 - 5.6e-39 133.5 0.2 5.6e-39 133.5 0.1 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EWC44821.1 - 1.7e-06 27.7 13.4 3.2e-06 26.9 9.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sugar_tr PF00083.19 EWC44825.1 - 2.7e-79 266.8 27.6 3.3e-79 266.5 19.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EWC44825.1 - 1.4e-20 73.2 23.5 2.1e-11 43.1 5.6 2.3 2 1 0 2 2 2 2 Major Facilitator Superfamily CHAT PF12770.2 EWC44826.1 - 8.3e-34 117.0 0.0 1.4e-33 116.2 0.0 1.4 1 0 0 1 1 1 1 CHAT domain DUF479 PF04336.7 EWC44826.1 - 0.0027 17.7 0.7 4.3 7.4 0.0 3.6 4 0 0 4 4 4 2 Protein of unknown function, DUF479 TPR_12 PF13424.1 EWC44826.1 - 0.0086 15.9 12.9 1.9 8.5 0.1 5.9 5 2 1 6 6 6 3 Tetratricopeptide repeat TPR_11 PF13414.1 EWC44826.1 - 0.028 14.0 8.1 1.4 8.5 0.1 5.8 3 3 4 7 7 7 0 TPR repeat TPR_1 PF00515.23 EWC44826.1 - 0.38 10.4 2.2 5.3 6.8 0.0 3.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.12 EWC44826.1 - 2.7 8.1 9.6 3.8 7.6 0.0 5.2 6 0 0 6 6 6 0 Tetratricopeptide repeat Rib_5-P_isom_A PF06026.9 EWC44827.1 - 1.6e-27 95.8 0.0 2.3e-27 95.4 0.0 1.2 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) Methyltransf_26 PF13659.1 EWC44828.1 - 6.3e-12 45.5 0.0 1.3e-11 44.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EWC44828.1 - 7.7e-07 29.6 0.0 1.3e-06 28.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EWC44828.1 - 1.9e-06 27.5 0.0 7.3e-06 25.6 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 EWC44828.1 - 6.3e-05 23.2 0.0 0.00016 21.9 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EWC44828.1 - 0.00016 21.0 0.0 0.21 10.9 0.0 2.4 1 1 0 2 2 2 2 Methyltransferase small domain Methyltransf_23 PF13489.1 EWC44828.1 - 0.002 17.8 0.0 0.025 14.2 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain FtsJ PF01728.14 EWC44828.1 - 0.013 15.5 0.0 0.021 14.8 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase UPF0020 PF01170.13 EWC44828.1 - 0.016 14.8 0.0 0.31 10.6 0.0 2.2 2 0 0 2 2 2 0 Putative RNA methylase family UPF0020 N6_Mtase PF02384.11 EWC44828.1 - 0.018 14.0 0.0 0.091 11.8 0.0 1.9 1 1 0 1 1 1 0 N-6 DNA Methylase Ubie_methyltran PF01209.13 EWC44828.1 - 0.023 13.7 0.0 0.036 13.1 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Cons_hypoth95 PF03602.10 EWC44828.1 - 0.03 13.7 0.0 2.4 7.5 0.0 2.2 2 0 0 2 2 2 0 Conserved hypothetical protein 95 CheR PF01739.13 EWC44828.1 - 0.18 11.0 0.0 0.39 9.9 0.0 1.5 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain tRNA-synt_1 PF00133.17 EWC44829.1 - 4.4e-52 176.9 0.0 5.3e-31 107.2 0.0 6.0 2 1 1 3 3 3 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1_2 PF13603.1 EWC44829.1 - 1.5e-33 115.6 0.0 4.7e-33 114.0 0.0 1.9 2 1 0 2 2 2 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1g PF09334.6 EWC44829.1 - 8.1e-28 97.1 0.0 4.5e-21 74.9 0.0 4.1 3 1 0 3 3 3 2 tRNA synthetases class I (M) Anticodon_1 PF08264.8 EWC44829.1 - 7e-10 38.8 0.0 1.6e-09 37.7 0.0 1.5 1 1 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.14 EWC44829.1 - 0.0019 17.3 0.0 1.2 8.2 0.0 2.9 3 1 0 3 3 3 2 tRNA synthetases class I (C) catalytic domain Propep_M14 PF02244.11 EWC44829.1 - 0.028 14.1 0.0 0.069 12.8 0.0 1.6 1 0 0 1 1 1 0 Carboxypeptidase activation peptide tRNA-synt_1d PF00750.14 EWC44829.1 - 0.037 12.8 0.0 0.061 12.1 0.0 1.2 1 0 0 1 1 1 0 tRNA synthetases class I (R) Nudix_N_2 PF14803.1 EWC44829.1 - 0.67 9.6 2.6 3.2 7.4 0.2 2.6 2 0 0 2 2 2 0 Nudix N-terminal Mso1_Sec1_bdg PF14475.1 EWC44831.1 - 2.2e-07 30.1 0.0 3.4e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 Sec1-binding region of Mso1 CDC27 PF09507.5 EWC44831.1 - 3.9 6.5 10.2 1.6 7.8 5.5 1.4 1 1 0 1 1 1 0 DNA polymerase subunit Cdc27 SOG2 PF10428.4 EWC44831.1 - 8.2 4.9 8.2 12 4.4 5.7 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Ribosomal_L28e PF01778.12 EWC44832.1 - 7.2e-32 110.2 2.0 2e-31 108.8 0.1 2.2 2 0 0 2 2 2 1 Ribosomal L28e protein family Mak16 PF04874.9 EWC44832.1 - 7.6e-23 80.5 15.4 7.6e-23 80.5 10.6 3.9 2 1 1 3 3 3 1 Mak16 protein C-terminal region CENP-T PF15511.1 EWC44832.1 - 0.098 11.8 19.6 0.14 11.3 13.6 1.2 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T Nop14 PF04147.7 EWC44832.1 - 0.92 7.3 33.4 1.4 6.7 23.2 1.3 1 0 0 1 1 1 0 Nop14-like family Apt1 PF10351.4 EWC44832.1 - 2.2 7.0 9.5 3.2 6.4 6.6 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain RabGAP-TBC PF00566.13 EWC44833.1 - 7.7e-38 130.1 0.8 1.4e-37 129.3 0.6 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF3548 PF12068.3 EWC44833.1 - 3.3e-12 46.1 0.0 5.2e-09 35.6 0.0 3.0 2 1 0 2 2 2 2 Domain of unknown function (DUF3548) Ank_2 PF12796.2 EWC44835.1 - 2.5e-24 85.4 0.8 3e-12 46.6 0.0 2.9 1 1 2 3 3 3 2 Ankyrin repeats (3 copies) Ank PF00023.25 EWC44835.1 - 2.7e-15 55.3 2.8 3.2e-06 26.6 0.3 5.2 5 0 0 5 5 5 3 Ankyrin repeat Ank_3 PF13606.1 EWC44835.1 - 1.5e-14 52.5 0.4 5.7e-05 22.9 0.0 5.3 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.1 EWC44835.1 - 9e-14 51.5 0.3 1.8e-07 31.4 0.0 3.6 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.1 EWC44835.1 - 4.9e-08 32.9 0.1 0.0001 22.4 0.0 2.9 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Aminotran_5 PF00266.14 EWC44837.1 - 9.2e-23 80.5 0.0 3.6e-15 55.5 0.0 2.1 2 0 0 2 2 2 2 Aminotransferase class-V ABC_tran PF00005.22 EWC44838.1 - 5.1e-32 111.0 0.0 6.7e-32 110.6 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 EWC44838.1 - 1.2e-06 28.7 0.0 0.013 15.4 0.0 2.1 2 0 0 2 2 2 2 AAA domain ABC_ATPase PF09818.4 EWC44838.1 - 2.8e-06 26.2 0.0 8.9e-05 21.2 0.0 2.4 2 1 0 2 2 2 1 Predicted ATPase of the ABC class AAA_16 PF13191.1 EWC44838.1 - 3.9e-05 23.7 0.4 8.3e-05 22.6 0.3 1.7 1 1 0 1 1 1 1 AAA ATPase domain SMC_N PF02463.14 EWC44838.1 - 8.5e-05 21.8 0.1 0.24 10.5 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 EWC44838.1 - 0.00032 20.1 0.0 0.00064 19.2 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_25 PF13481.1 EWC44838.1 - 0.0004 19.8 0.2 0.013 14.8 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.1 EWC44838.1 - 0.0048 16.5 0.2 0.052 13.1 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 EWC44838.1 - 0.0053 16.9 0.0 0.02 15.0 0.0 1.9 1 1 0 1 1 1 1 AAA domain DUF258 PF03193.11 EWC44838.1 - 0.009 15.2 0.0 0.015 14.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Zeta_toxin PF06414.7 EWC44838.1 - 0.014 14.5 0.0 0.026 13.6 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin Miro PF08477.8 EWC44838.1 - 0.025 15.0 0.1 0.046 14.2 0.0 1.3 1 0 0 1 1 1 0 Miro-like protein SbcCD_C PF13558.1 EWC44838.1 - 0.035 14.0 0.1 0.22 11.4 0.1 2.1 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_17 PF13207.1 EWC44838.1 - 0.055 14.3 0.0 0.085 13.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_10 PF12846.2 EWC44838.1 - 0.059 12.7 0.3 0.17 11.2 0.2 1.7 1 1 1 2 2 2 0 AAA-like domain MobB PF03205.9 EWC44838.1 - 0.076 12.7 0.0 0.15 11.7 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_24 PF13479.1 EWC44838.1 - 0.12 11.9 0.0 0.32 10.5 0.0 1.8 1 1 0 1 1 1 0 AAA domain NACHT PF05729.7 EWC44838.1 - 0.14 11.7 0.0 0.27 10.8 0.0 1.4 1 0 0 1 1 1 0 NACHT domain MMR_HSR1 PF01926.18 EWC44838.1 - 0.16 11.9 0.0 0.26 11.2 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_23 PF13476.1 EWC44838.1 - 0.16 12.2 0.0 0.23 11.7 0.0 1.1 1 0 0 1 1 1 0 AAA domain Abhydrolase_1 PF00561.15 EWC44839.1 - 1.1e-13 51.2 0.0 1.9e-13 50.5 0.0 1.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 EWC44839.1 - 3.4e-11 43.4 0.0 5.2e-11 42.8 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family EGF_CA PF07645.10 EWC44841.1 - 0.053 13.5 6.2 0.13 12.2 4.3 1.7 1 1 0 1 1 1 0 Calcium-binding EGF domain EGF_3 PF12947.2 EWC44841.1 - 0.76 9.7 14.6 0.046 13.6 3.4 2.6 2 0 0 2 2 2 0 EGF domain Ank_2 PF12796.2 EWC44842.1 - 1.2e-23 83.2 2.0 3.2e-11 43.4 0.1 3.7 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 EWC44842.1 - 2.8e-16 58.4 10.4 5.6e-06 25.9 0.5 6.0 5 1 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.1 EWC44842.1 - 3.5e-15 56.0 1.4 2.7e-06 27.7 0.0 4.8 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Ank_5 PF13857.1 EWC44842.1 - 4.3e-12 45.8 6.6 3.3e-05 23.9 0.2 4.9 1 1 3 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 EWC44842.1 - 1.1e-10 40.6 4.4 0.14 12.4 0.2 5.9 5 1 0 5 5 5 3 Ankyrin repeat HeLo PF14479.1 EWC44843.1 - 9.3e-10 38.6 0.3 1.6e-08 34.5 0.0 2.3 2 0 0 2 2 2 1 Prion-inhibition and propagation Catalase PF00199.14 EWC44844.1 - 1.8e-172 573.3 0.0 2.1e-172 573.0 0.0 1.0 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.7 EWC44844.1 - 1.4e-10 40.8 0.2 3.8e-10 39.4 0.0 1.8 2 0 0 2 2 2 1 Catalase-related immune-responsive GMC_oxred_N PF00732.14 EWC44845.1 - 5.2e-51 173.5 0.0 6.5e-51 173.2 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.8 EWC44845.1 - 7e-34 117.1 0.0 1.1e-33 116.5 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.19 EWC44845.1 - 1.1e-05 24.4 0.2 0.11 11.2 0.3 2.1 2 0 0 2 2 2 2 FAD binding domain Lycopene_cycl PF05834.7 EWC44845.1 - 0.0019 17.2 0.0 0.0034 16.3 0.0 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein DAO PF01266.19 EWC44845.1 - 0.0045 15.9 0.3 0.1 11.4 0.2 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 EWC44845.1 - 0.0058 16.7 0.0 3.9 7.4 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 EWC44845.1 - 0.011 15.5 0.0 0.053 13.4 0.0 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 EWC44845.1 - 0.023 14.6 0.3 0.051 13.6 0.2 1.5 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Thi4 PF01946.12 EWC44845.1 - 0.032 13.3 0.1 0.058 12.4 0.1 1.4 1 0 0 1 1 1 0 Thi4 family Trp_halogenase PF04820.9 EWC44845.1 - 0.27 9.8 0.2 0.37 9.3 0.1 1.1 1 0 0 1 1 1 0 Tryptophan halogenase Piwi PF02171.12 EWC44847.1 - 1.1e-61 208.4 0.0 1.3e-61 208.1 0.0 1.1 1 0 0 1 1 1 1 Piwi domain DUF1785 PF08699.5 EWC44848.1 - 9.6e-05 21.6 0.0 0.00018 20.8 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1785) PLDc_N PF13396.1 EWC44850.1 - 5.7e-12 45.1 3.5 7.5e-12 44.7 2.4 1.2 1 0 0 1 1 1 1 Phospholipase_D-nuclease N-terminal DUF3309 PF11752.3 EWC44850.1 - 0.01 15.5 2.1 0.01 15.5 1.5 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3309) NfeD PF01957.13 EWC44850.1 - 0.033 14.3 0.4 0.035 14.2 0.3 1.1 1 0 0 1 1 1 0 NfeD-like C-terminal, partner-binding DUF3951 PF13131.1 EWC44850.1 - 0.045 13.5 0.2 0.045 13.5 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3951) MpPF26 PF07666.6 EWC44850.1 - 0.062 13.1 0.5 0.079 12.8 0.4 1.1 1 0 0 1 1 1 0 M penetrans paralogue family 26 DUF4199 PF13858.1 EWC44850.1 - 0.076 12.9 1.3 0.096 12.6 0.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) DUF1980 PF09323.5 EWC44850.1 - 0.12 12.1 1.9 0.15 11.8 1.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) FixQ PF05545.6 EWC44850.1 - 0.14 11.8 0.2 0.14 11.8 0.1 2.0 2 0 0 2 2 2 0 Cbb3-type cytochrome oxidase component FixQ DUF2207 PF09972.4 EWC44850.1 - 0.15 10.6 0.7 0.17 10.4 0.5 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Cation_ATPase_C PF00689.16 EWC44850.1 - 0.55 9.7 3.4 0.68 9.4 2.4 1.1 1 0 0 1 1 1 0 Cation transporting ATPase, C-terminus CENP-F_leu_zip PF10473.4 EWC44851.1 - 3e-05 23.9 0.1 3.5e-05 23.6 0.1 1.1 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 HALZ PF02183.13 EWC44851.1 - 4.4e-05 23.1 1.4 6.2e-05 22.6 1.0 1.2 1 0 0 1 1 1 1 Homeobox associated leucine zipper TMF_TATA_bd PF12325.3 EWC44851.1 - 0.0012 18.6 0.6 0.0014 18.3 0.4 1.1 1 0 0 1 1 1 1 TATA element modulatory factor 1 TATA binding DivIC PF04977.10 EWC44851.1 - 0.0087 15.5 0.0 0.011 15.2 0.0 1.2 1 0 0 1 1 1 1 Septum formation initiator DUF4201 PF13870.1 EWC44851.1 - 0.0095 15.3 0.5 0.012 15.0 0.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4201) APG6 PF04111.7 EWC44851.1 - 0.011 14.8 0.0 0.011 14.8 0.0 1.0 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF4140 PF13600.1 EWC44851.1 - 0.02 15.3 0.1 0.021 15.2 0.1 1.2 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) bZIP_1 PF00170.16 EWC44851.1 - 0.02 14.8 0.9 0.026 14.4 0.6 1.1 1 0 0 1 1 1 0 bZIP transcription factor MAD PF05557.8 EWC44851.1 - 0.021 12.9 0.2 0.023 12.8 0.1 1.0 1 0 0 1 1 1 0 Mitotic checkpoint protein TMF_DNA_bd PF12329.3 EWC44851.1 - 0.027 14.2 0.1 0.032 14.0 0.1 1.1 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding NTR2 PF15458.1 EWC44851.1 - 0.037 13.2 0.4 0.041 13.1 0.2 1.1 1 0 0 1 1 1 0 Nineteen complex-related protein 2 Golgin_A5 PF09787.4 EWC44851.1 - 0.037 12.5 1.2 0.04 12.4 0.8 1.0 1 0 0 1 1 1 0 Golgin subfamily A member 5 HAP1_N PF04849.8 EWC44851.1 - 0.059 12.3 0.2 0.061 12.2 0.1 1.0 1 0 0 1 1 1 0 HAP1 N-terminal conserved region GAS PF13851.1 EWC44851.1 - 0.062 12.4 0.1 0.075 12.2 0.1 1.0 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding CCDC155 PF14662.1 EWC44851.1 - 0.068 12.7 0.3 0.08 12.5 0.2 1.1 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 ATG16 PF08614.6 EWC44851.1 - 0.071 12.9 0.3 0.088 12.6 0.2 1.2 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) KAAG1 PF15354.1 EWC44851.1 - 0.17 12.2 0.7 0.24 11.7 0.5 1.3 1 0 0 1 1 1 0 Kidney-associated antigen 1 SR-25 PF10500.4 EWC44851.1 - 0.41 10.0 5.1 0.43 10.0 3.5 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF2235 PF09994.4 EWC44852.1 - 7.9e-91 304.2 0.1 1e-90 303.9 0.1 1.1 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) bZIP_1 PF00170.16 EWC44853.1 - 0.0029 17.5 10.4 0.0056 16.6 4.7 2.2 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.10 EWC44853.1 - 0.0074 16.0 10.1 0.019 14.7 4.1 2.2 2 0 0 2 2 2 1 Basic region leucine zipper COX16 PF14138.1 EWC44853.1 - 0.16 12.1 0.7 0.3 11.2 0.5 1.4 1 0 0 1 1 1 0 Cytochrome c oxidase assembly protein COX16 Peptidase_S28 PF05577.7 EWC44855.1 - 3e-59 200.7 0.6 5.5e-59 199.8 0.4 1.4 1 1 0 1 1 1 1 Serine carboxypeptidase S28 Abhydrolase_6 PF12697.2 EWC44855.1 - 1.1e-05 25.4 0.1 2.1e-05 24.5 0.1 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EWC44855.1 - 0.047 13.2 0.2 0.17 11.4 0.0 2.1 2 0 0 2 2 2 0 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EWC44855.1 - 0.06 13.0 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family Ponericin PF07442.6 EWC44855.1 - 0.12 12.1 0.1 0.29 10.9 0.1 1.6 1 0 0 1 1 1 0 Ponericin MARVEL PF01284.18 EWC44856.1 - 2.4e-12 46.8 11.1 4.2e-11 42.8 7.3 2.0 1 1 1 2 2 2 1 Membrane-associating domain DUF2910 PF11139.3 EWC44856.1 - 0.061 12.4 7.3 0.088 11.9 5.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2910) Claudin_2 PF13903.1 EWC44856.1 - 0.57 9.8 14.0 1 9.0 4.3 2.6 1 1 1 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction DUF4389 PF14333.1 EWC44856.1 - 2.3 7.9 8.6 6.6 6.5 0.6 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4389) YtpI PF14007.1 EWC44856.1 - 2.8 7.9 6.7 12 5.9 0.0 3.0 2 1 0 2 2 2 0 YtpI-like protein DUF2157 PF09925.4 EWC44856.1 - 2.9 7.4 7.8 4.1 6.9 3.5 2.2 2 1 0 2 2 2 0 Predicted membrane protein (DUF2157) PQ-loop PF04193.9 EWC44856.1 - 6.6 6.3 7.0 4.8 6.8 0.5 2.8 3 1 0 3 3 3 0 PQ loop repeat NUDIX PF00293.23 EWC44862.1 - 5.8e-20 71.3 0.7 6.8e-19 67.8 0.0 2.2 1 1 0 2 2 2 1 NUDIX domain His_Phos_1 PF00300.17 EWC44864.1 - 4.4e-15 56.1 0.1 6.6e-15 55.5 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) F-box-like PF12937.2 EWC44867.1 - 0.049 13.3 0.2 0.18 11.5 0.1 2.1 2 0 0 2 2 2 0 F-box-like DUF387 PF04079.11 EWC44868.1 - 0.0035 16.7 0.0 0.0067 15.8 0.0 1.4 1 0 0 1 1 1 1 Putative transcriptional regulators (Ypuh-like) F-box-like PF12937.2 EWC44868.1 - 0.0092 15.6 0.5 0.019 14.6 0.3 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EWC44868.1 - 0.083 12.5 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 F-box domain F-box PF00646.28 EWC44870.1 - 0.00029 20.4 0.0 0.00043 19.8 0.0 1.3 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 EWC44870.1 - 0.0014 18.3 0.1 0.0024 17.5 0.1 1.4 1 0 0 1 1 1 1 F-box-like SNAPc19 PF15497.1 EWC44871.1 - 0.014 15.5 0.1 0.014 15.5 0.1 2.4 2 1 0 2 2 2 0 snRNA-activating protein complex subunit 19, SNAPc subunit 19 F-box-like PF12937.2 EWC44873.1 - 0.0058 16.3 0.1 0.013 15.1 0.1 1.6 1 0 0 1 1 1 1 F-box-like PI-PLC-X PF00388.14 EWC44876.1 - 1.2e-57 193.3 0.0 2.1e-57 192.6 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.14 EWC44876.1 - 2.5e-37 127.4 0.0 4.2e-37 126.7 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain zf-C2H2_4 PF13894.1 EWC44877.1 - 2.6e-05 24.2 13.9 0.16 12.3 0.8 4.6 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2 PF00096.21 EWC44877.1 - 0.001 19.2 21.2 0.02 15.2 0.6 5.5 4 1 0 4 4 4 2 Zinc finger, C2H2 type Sina PF03145.11 EWC44877.1 - 0.01 15.5 3.4 0.018 14.7 2.3 1.3 1 0 0 1 1 1 0 Seven in absentia protein family CAP PF00188.21 EWC44879.1 - 9.3e-12 45.5 0.6 4.7e-11 43.2 0.4 2.3 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Dam PF05869.6 EWC44879.1 - 0.13 11.6 0.1 0.21 11.0 0.1 1.2 1 0 0 1 1 1 0 DNA N-6-adenine-methyltransferase (Dam) zf-C2H2 PF00096.21 EWC44881.1 - 0.021 15.1 29.3 0.1 13.0 0.3 5.2 4 0 0 4 4 4 0 Zinc finger, C2H2 type AA_permease_2 PF13520.1 EWC44884.1 - 4.4e-78 262.7 34.0 5.6e-78 262.3 23.6 1.2 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EWC44884.1 - 1.7e-18 66.2 27.2 2.7e-18 65.5 18.7 1.4 1 1 1 2 2 2 1 Amino acid permease HNH_2 PF13391.1 EWC44887.1 - 4.9e-09 35.8 0.4 1.2e-08 34.5 0.3 1.7 1 0 0 1 1 1 1 HNH endonuclease PGA2 PF07543.7 EWC44887.1 - 0.15 11.8 2.8 0.24 11.1 1.9 1.3 1 0 0 1 1 1 0 Protein trafficking PGA2 PROL5-SMR PF15621.1 EWC44888.1 - 1.5 9.2 5.4 1.8 9.0 3.7 1.3 1 0 0 1 1 1 0 Proline-rich submaxillary gland androgen-regulated family DUF3724 PF12521.3 EWC44888.1 - 6 6.7 8.3 2.3 8.0 0.8 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3724) Acyl-thio_N PF12590.3 EWC44890.1 - 0.044 14.2 0.0 0.14 12.6 0.0 1.8 1 1 1 2 2 2 0 Acyl-ATP thioesterase DUF4258 PF14076.1 EWC44890.1 - 0.049 13.6 0.0 0.083 12.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4258) DAO PF01266.19 EWC44895.1 - 2.7e-06 26.5 0.0 5.5e-06 25.5 0.0 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EWC44895.1 - 0.0016 18.4 0.0 0.0033 17.4 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 EWC44895.1 - 0.002 17.9 0.0 0.0097 15.6 0.0 2.1 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.9 EWC44895.1 - 0.082 12.7 0.0 0.27 11.0 0.0 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Methyltransf_2 PF00891.13 EWC44896.1 - 9.8e-26 90.4 0.0 2.5e-25 89.0 0.0 1.6 2 0 0 2 2 2 1 O-methyltransferase Methyltransf_18 PF12847.2 EWC44896.1 - 1.9e-05 25.2 0.0 4.3e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EWC44896.1 - 0.018 14.6 0.0 0.031 13.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_4 PF02390.12 EWC44896.1 - 0.16 11.0 0.0 0.23 10.4 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase VWA_3 PF13768.1 EWC44897.1 - 6.5e-28 97.3 0.0 1.2e-27 96.4 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VIT PF08487.5 EWC44897.1 - 5.4e-15 55.1 0.0 1e-14 54.2 0.0 1.4 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA_2 PF13519.1 EWC44897.1 - 1.5e-09 38.2 0.0 4.5e-09 36.6 0.0 1.8 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA PF00092.23 EWC44897.1 - 9.8e-08 31.9 0.0 1.8e-07 31.0 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.9 EWC44897.1 - 0.029 13.5 0.0 0.048 12.7 0.0 1.3 1 0 0 1 1 1 0 VWA domain containing CoxE-like protein VIT_2 PF13757.1 EWC44897.1 - 0.029 13.8 1.4 0.036 13.5 0.0 1.9 2 0 0 2 2 2 0 Vault protein inter-alpha-trypsin domain Mito_fiss_reg PF05308.6 EWC44898.1 - 3.6 6.8 8.6 0.16 11.3 2.2 1.6 2 0 0 2 2 2 0 Mitochondrial fission regulator Glyco_hydro_38 PF01074.17 EWC44899.1 - 1.4e-89 300.0 1.7 1.5e-89 299.9 0.3 1.7 2 0 0 2 2 2 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.8 EWC44899.1 - 4.7e-68 230.0 0.0 8.1e-68 229.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.6 EWC44899.1 - 3.6e-25 87.9 0.3 8.7e-25 86.7 0.2 1.7 1 0 0 1 1 1 1 Alpha mannosidase, middle domain DUF726 PF05277.7 EWC44900.1 - 2.6e-128 427.7 2.8 3.7e-128 427.2 1.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF726) Lipase_3 PF01764.20 EWC44900.1 - 0.0048 16.5 0.0 0.011 15.3 0.0 1.6 1 0 0 1 1 1 1 Lipase (class 3) HSP70 PF00012.15 EWC44901.1 - 1.9e-235 782.3 9.0 2.1e-235 782.2 6.3 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 EWC44901.1 - 2.8e-15 55.7 0.9 7.4e-14 51.0 0.2 2.2 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.11 EWC44901.1 - 0.00029 20.5 0.0 0.00064 19.3 0.0 1.6 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain DDR PF08841.5 EWC44901.1 - 0.0067 15.3 0.6 0.13 11.1 0.1 2.3 2 0 0 2 2 2 1 Diol dehydratase reactivase ATPase-like domain Flavodoxin_5 PF12724.2 EWC44901.1 - 0.051 13.5 1.3 20 5.1 0.0 3.2 2 1 1 3 3 3 0 Flavodoxin domain FtsA PF14450.1 EWC44901.1 - 1.1 9.0 10.0 0.91 9.3 0.2 3.6 3 3 0 3 3 3 0 Cell division protein FtsA Glyco_hydro_18 PF00704.23 EWC44902.1 - 2.4e-57 194.9 4.3 4.2e-57 194.1 3.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 LysM PF01476.15 EWC44902.1 - 8.1e-10 38.4 0.1 0.00059 19.6 0.0 3.2 2 0 0 2 2 2 2 LysM domain Chitin_bind_1 PF00187.14 EWC44902.1 - 0.00017 21.4 3.3 0.00017 21.4 2.3 3.5 3 0 0 3 3 3 1 Chitin recognition protein DUF3142 PF11340.3 EWC44902.1 - 0.022 14.3 0.0 0.049 13.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3142) STT3 PF02516.9 EWC44905.1 - 5.6e-134 447.7 42.3 2.1e-130 435.9 27.1 2.3 2 0 0 2 2 2 2 Oligosaccharyl transferase STT3 subunit PCI_Csn8 PF10075.4 EWC44906.1 - 2.9e-20 72.5 0.0 4e-20 72.0 0.0 1.2 1 0 0 1 1 1 1 COP9 signalosome, subunit CSN8 SAC3_GANP PF03399.11 EWC44906.1 - 0.00047 19.7 0.3 0.00061 19.4 0.2 1.1 1 0 0 1 1 1 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family SH3_1 PF00018.23 EWC44908.1 - 1.1e-37 127.1 5.7 1.3e-14 53.3 0.1 4.3 4 0 0 4 4 4 3 SH3 domain SHD1 PF03983.7 EWC44908.1 - 3.9e-32 109.7 0.1 8e-32 108.7 0.1 1.5 1 0 0 1 1 1 1 SLA1 homology domain 1, SHD1 SH3_9 PF14604.1 EWC44908.1 - 6.3e-31 105.7 7.5 1.1e-10 40.9 0.1 4.0 4 0 0 4 4 4 3 Variant SH3 domain SH3_2 PF07653.12 EWC44908.1 - 3.1e-25 87.4 0.1 3e-06 26.6 0.0 4.3 4 0 0 4 4 4 4 Variant SH3 domain SH3_3 PF08239.6 EWC44908.1 - 0.00054 20.0 2.0 0.28 11.3 0.2 3.5 3 0 0 3 3 3 1 Bacterial SH3 domain Gastrin PF00918.12 EWC44908.1 - 8.5 7.2 10.9 18 6.1 6.4 2.4 2 0 0 2 2 2 0 Gastrin/cholecystokinin family Methyltransf_23 PF13489.1 EWC44909.1 - 6.7e-08 32.4 0.1 9.8e-08 31.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EWC44909.1 - 7.8e-05 23.0 0.0 0.00015 22.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EWC44909.1 - 0.0063 16.9 0.0 0.011 16.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EWC44909.1 - 0.023 15.2 0.0 0.042 14.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_PK PF05891.7 EWC44909.1 - 0.19 10.9 0.8 0.63 9.3 0.0 1.9 1 1 1 2 2 2 0 AdoMet dependent proline di-methyltransferase Fcf1 PF04900.7 EWC44910.1 - 8.3e-24 83.6 0.1 1.6e-23 82.7 0.1 1.5 1 0 0 1 1 1 1 Fcf1 zf-Di19 PF05605.7 EWC44911.1 - 0.24 11.5 4.6 0.75 9.9 3.2 1.9 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding Rad17 PF03215.10 EWC44913.1 - 7.1e-60 203.1 0.0 1e-59 202.6 0.0 1.1 1 0 0 1 1 1 1 Rad17 cell cycle checkpoint protein AAA_16 PF13191.1 EWC44913.1 - 0.00012 22.0 0.1 0.0008 19.4 0.0 2.4 1 1 2 3 3 3 1 AAA ATPase domain AAA_22 PF13401.1 EWC44913.1 - 0.00014 21.9 0.0 0.0084 16.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA PF00004.24 EWC44913.1 - 0.00016 21.9 0.0 0.00081 19.5 0.0 2.2 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.1 EWC44913.1 - 0.0062 16.2 0.2 0.018 14.7 0.1 1.7 1 0 0 1 1 1 1 Part of AAA domain Zeta_toxin PF06414.7 EWC44913.1 - 0.046 12.8 0.0 0.11 11.5 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin AAA_25 PF13481.1 EWC44913.1 - 0.083 12.2 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.1 EWC44913.1 - 0.084 13.6 0.0 0.22 12.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain zf-C2H2_4 PF13894.1 EWC44914.1 - 0.13 12.6 17.7 1.5 9.3 2.2 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2 PF00096.21 EWC44914.1 - 2.4 8.6 10.4 0.17 12.2 1.3 2.6 2 0 0 2 2 2 0 Zinc finger, C2H2 type SH3_9 PF14604.1 EWC44915.1 - 1e-28 98.6 3.9 8.2e-15 54.1 0.2 2.4 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.23 EWC44915.1 - 2.6e-24 84.3 4.3 1.6e-12 46.5 0.1 2.4 2 0 0 2 2 2 2 SH3 domain SH3_2 PF07653.12 EWC44915.1 - 8.4e-19 66.8 0.0 7.3e-09 34.9 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain Cofilin_ADF PF00241.15 EWC44915.1 - 2.2e-09 37.2 0.0 4.2e-09 36.3 0.0 1.4 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein F-box-like PF12937.2 EWC44916.1 - 1.6e-06 27.7 0.1 3.6e-06 26.5 0.1 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EWC44916.1 - 0.0032 17.0 1.1 0.0049 16.5 0.1 1.8 2 0 0 2 2 2 1 F-box domain WD40 PF00400.27 EWC44917.1 - 2.1e-14 52.7 0.9 0.66 9.9 0.1 7.4 7 0 0 7 7 7 5 WD domain, G-beta repeat Ank_2 PF12796.2 EWC44918.1 - 7.3e-23 80.7 0.0 9e-11 41.9 0.0 2.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 EWC44918.1 - 1.9e-15 55.7 0.6 1.4e-07 30.9 0.1 3.8 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.1 EWC44918.1 - 4.7e-13 48.0 0.2 4.7e-05 23.2 0.1 4.2 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.1 EWC44918.1 - 7.2e-13 48.6 0.1 1.1e-06 28.9 0.1 3.7 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 EWC44918.1 - 2.9e-10 40.0 0.4 2.1e-06 27.7 0.7 3.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) TPR_19 PF14559.1 EWC44918.1 - 0.067 13.5 1.0 0.82 10.0 0.9 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat Acetyltransf_1 PF00583.19 EWC44919.1 - 1.2e-07 31.6 0.0 2.2e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 EWC44919.1 - 2.5e-06 27.5 0.0 4.6e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 EWC44919.1 - 2e-05 24.6 0.0 4.8e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 EWC44919.1 - 0.0017 18.2 0.1 0.0051 16.6 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 EWC44919.1 - 0.0028 17.3 0.0 0.0066 16.1 0.0 1.6 1 1 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.1 EWC44919.1 - 0.12 12.3 0.0 0.25 11.2 0.0 1.5 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase CHAT PF12770.2 EWC44920.1 - 4.9e-26 91.5 0.0 1.4e-22 80.1 0.0 2.5 2 0 0 2 2 2 2 CHAT domain TPR_2 PF07719.12 EWC44920.1 - 1.3e-07 30.9 18.8 1.4 9.0 0.0 7.4 6 1 1 7 7 7 4 Tetratricopeptide repeat Apc3 PF12895.2 EWC44920.1 - 0.0098 16.0 10.1 0.85 9.7 0.4 4.3 4 0 0 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.23 EWC44920.1 - 0.019 14.5 6.8 18 5.1 0.0 5.3 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_4 PF07721.9 EWC44920.1 - 0.043 14.2 6.8 0.25 11.8 1.0 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.1 EWC44920.1 - 0.061 13.2 22.6 4.1 7.4 0.0 5.7 5 2 0 5 5 5 0 Tetratricopeptide repeat TPR_16 PF13432.1 EWC44920.1 - 0.38 11.4 21.8 0.23 12.1 0.2 5.2 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_19 PF14559.1 EWC44920.1 - 1.2 9.5 14.9 4.8 7.5 0.2 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.1 EWC44920.1 - 1.4 9.5 6.9 31 5.3 0.1 4.8 4 0 0 4 4 4 0 Tetratricopeptide repeat ADK PF00406.17 EWC44922.1 - 2.3e-39 134.6 0.0 2.8e-39 134.3 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase ADK_lid PF05191.9 EWC44922.1 - 8.2e-15 54.1 0.0 1.4e-14 53.4 0.0 1.3 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_33 PF13671.1 EWC44922.1 - 0.00011 22.1 0.0 0.00027 20.8 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 EWC44922.1 - 0.00015 22.5 0.0 0.00022 22.0 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 EWC44922.1 - 0.0016 18.7 0.0 0.0029 17.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 EWC44922.1 - 0.0081 15.2 0.0 0.011 14.8 0.0 1.2 1 0 0 1 1 1 1 Zeta toxin Mg_chelatase PF01078.16 EWC44922.1 - 0.035 13.2 0.0 0.054 12.6 0.0 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI FliG_M PF14841.1 EWC44922.1 - 0.039 13.9 0.0 0.11 12.4 0.0 1.7 1 0 0 1 1 1 0 FliG middle domain LETM1 PF07766.8 EWC44923.1 - 2.9e-105 351.1 1.3 4.3e-105 350.5 0.9 1.2 1 0 0 1 1 1 1 LETM1-like protein SAP PF02037.22 EWC44923.1 - 0.001 18.4 0.0 0.11 12.0 0.0 2.5 2 0 0 2 2 2 2 SAP domain Gly_transf_sug PF04488.10 EWC44924.1 - 1.4e-10 41.4 0.7 2.6e-10 40.6 0.5 1.4 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Caps_synth PF05704.7 EWC44924.1 - 0.0081 15.3 0.0 0.015 14.4 0.0 1.3 1 0 0 1 1 1 1 Capsular polysaccharide synthesis protein F-box PF00646.28 EWC44925.1 - 2e-06 27.3 0.5 6.9e-05 22.4 0.3 2.5 2 0 0 2 2 2 1 F-box domain SNase PF00565.12 EWC44926.1 - 1.5e-16 60.5 0.0 2.5e-16 59.8 0.0 1.3 1 0 0 1 1 1 1 Staphylococcal nuclease homologue SNARE PF05739.14 EWC44927.1 - 0.00048 19.7 2.2 0.00048 19.7 1.5 1.9 2 0 0 2 2 2 1 SNARE domain Histone_HNS PF00816.16 EWC44927.1 - 1.2 9.6 4.8 0.56 10.7 0.5 2.4 1 1 1 2 2 2 0 H-NS histone family Phos_pyr_kin PF08543.7 EWC44929.1 - 2.6e-12 46.4 0.0 4.3e-12 45.7 0.0 1.2 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.19 EWC44929.1 - 1.8e-10 40.4 0.0 7.5e-09 35.1 0.0 2.3 2 1 0 2 2 2 1 pfkB family carbohydrate kinase Glyco_hydro_43 PF04616.9 EWC44929.1 - 0.096 11.7 0.0 0.14 11.2 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolases family 43 dUTPase PF00692.14 EWC44930.1 - 9.1e-42 141.5 0.0 1.2e-41 141.2 0.0 1.1 1 0 0 1 1 1 1 dUTPase zf-H2C2_2 PF13465.1 EWC44931.1 - 1.6e-10 40.7 14.1 5.6e-06 26.3 0.0 3.8 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2 PF00096.21 EWC44931.1 - 7.2e-08 32.3 9.4 2e-05 24.6 3.1 3.6 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-met PF12874.2 EWC44931.1 - 5.3e-06 26.4 1.5 2e-05 24.6 1.0 2.1 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.1 EWC44931.1 - 1.4e-05 25.0 7.4 0.00021 21.4 1.6 3.2 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 EWC44931.1 - 0.00014 21.8 2.3 0.00014 21.8 1.6 3.7 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.1 EWC44931.1 - 0.0041 16.9 1.5 0.0041 16.9 1.1 3.5 3 1 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_2 PF12756.2 EWC44931.1 - 0.038 14.0 0.9 0.038 14.0 0.6 2.9 2 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-BED PF02892.10 EWC44931.1 - 0.21 11.3 2.8 0.62 9.8 0.4 2.4 2 0 0 2 2 2 0 BED zinc finger zf-RING_2 PF13639.1 EWC44932.1 - 0.014 15.1 0.2 0.025 14.3 0.1 1.3 1 0 0 1 1 1 0 Ring finger domain Rab5ip PF07019.7 EWC44933.1 - 1.7e-17 63.3 4.8 1.9e-17 63.1 3.3 1.1 1 0 0 1 1 1 1 Rab5-interacting protein (Rab5ip) WD40 PF00400.27 EWC44934.1 - 2.4e-73 239.5 22.1 4.2e-08 32.7 0.0 12.9 13 0 0 13 13 13 11 WD domain, G-beta repeat Utp12 PF04003.7 EWC44934.1 - 5.9e-15 55.1 0.0 1.2e-14 54.1 0.0 1.5 1 0 0 1 1 1 1 Dip2/Utp12 Family Nup160 PF11715.3 EWC44934.1 - 0.00026 19.2 9.9 0.073 11.1 0.1 5.1 5 1 0 5 5 5 3 Nucleoporin Nup120/160 eIF2A PF08662.6 EWC44934.1 - 0.0015 18.2 0.1 3.7 7.2 0.0 4.6 4 1 0 4 4 4 1 Eukaryotic translation initiation factor eIF2A Nucleoporin_N PF08801.6 EWC44934.1 - 0.0043 15.8 6.5 21 3.7 0.0 5.3 2 2 1 6 6 6 2 Nup133 N terminal like DUF3312 PF11768.3 EWC44934.1 - 0.016 13.5 0.1 0.64 8.1 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3312) P34-Arc PF04045.9 EWC44935.1 - 9.9e-105 349.1 0.1 1.2e-104 348.9 0.1 1.0 1 0 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc ARPC4 PF05856.7 EWC44935.1 - 0.0011 18.4 0.0 0.0025 17.2 0.0 1.6 1 0 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) Vezatin PF12632.2 EWC44937.1 - 4.1e-40 137.4 0.0 6.7e-40 136.7 0.0 1.3 1 0 0 1 1 1 1 Mysoin-binding motif of peroxisomes Caps_synth_CapC PF14102.1 EWC44937.1 - 0.037 14.1 0.5 0.07 13.2 0.3 1.3 1 0 0 1 1 1 0 Capsule biosynthesis CapC FAD_binding_2 PF00890.19 EWC44938.1 - 2.8e-85 286.6 0.3 4.3e-85 286.0 0.2 1.3 1 0 0 1 1 1 1 FAD binding domain Cyt-b5 PF00173.23 EWC44938.1 - 3.4e-21 74.8 0.1 2.7e-20 71.9 0.0 2.6 4 0 0 4 4 4 1 Cytochrome b5-like Heme/Steroid binding domain DAO PF01266.19 EWC44938.1 - 3.2e-12 46.0 2.0 4.3e-11 42.3 1.3 2.1 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 EWC44938.1 - 1.1e-08 35.1 0.0 5.7e-06 26.3 0.0 3.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 EWC44938.1 - 1.9e-08 33.8 0.2 4.7e-08 32.5 0.1 1.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EWC44938.1 - 1e-07 31.8 0.4 1e-07 31.8 0.3 3.4 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.9 EWC44938.1 - 0.00017 20.2 6.8 0.015 13.7 0.2 3.2 3 0 0 3 3 3 2 HI0933-like protein FAD_binding_3 PF01494.14 EWC44938.1 - 0.002 17.2 0.0 0.0028 16.7 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.12 EWC44938.1 - 0.0037 16.4 2.4 0.26 10.3 0.5 2.6 3 0 0 3 3 3 1 Thi4 family Amino_oxidase PF01593.19 EWC44938.1 - 0.004 16.2 0.2 0.31 10.0 0.1 2.2 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase Pyr_redox PF00070.22 EWC44938.1 - 0.0056 17.0 1.6 0.12 12.7 0.3 2.9 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 EWC44938.1 - 0.014 14.2 3.1 0.48 9.2 0.5 2.4 2 0 0 2 2 2 0 Glucose inhibited division protein A Pyr_redox_3 PF13738.1 EWC44938.1 - 0.029 14.4 0.5 0.071 13.1 0.4 1.8 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.1 EWC44938.1 - 0.05 13.8 0.0 0.17 12.1 0.0 1.9 2 0 0 2 2 2 0 Putative NAD(P)-binding Dpy-30 PF05186.8 EWC44939.1 - 2.2e-14 52.6 0.1 3.4e-14 52.0 0.1 1.3 1 0 0 1 1 1 1 Dpy-30 motif TPR_11 PF13414.1 EWC44940.1 - 0.00012 21.6 1.5 0.00038 20.0 0.2 2.2 2 0 0 2 2 2 1 TPR repeat SET PF00856.23 EWC44940.1 - 0.00014 22.2 0.2 0.0063 16.8 0.0 2.8 3 0 0 3 3 3 1 SET domain TPR_2 PF07719.12 EWC44940.1 - 0.11 12.4 0.7 5.4 7.1 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.1 EWC44940.1 - 0.25 12.0 10.2 0.67 10.7 1.8 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.1 EWC44940.1 - 1.1 10.0 6.8 11 6.9 0.2 3.5 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.1 EWC44940.1 - 1.6 9.1 8.4 0.77 10.1 0.6 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat zf-MYND PF01753.13 EWC44940.1 - 3.5 7.5 19.2 0.067 13.0 7.8 2.2 2 0 0 2 2 2 0 MYND finger TauD PF02668.11 EWC44941.1 - 2.3e-50 171.6 0.1 2.9e-50 171.3 0.1 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DAO PF01266.19 EWC44942.1 - 5.8e-28 97.8 1.5 1e-27 97.0 1.0 1.4 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 EWC44942.1 - 0.014 15.4 0.0 1.7 8.6 0.0 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 EWC44942.1 - 0.025 13.4 0.1 0.039 12.8 0.1 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein NAD_binding_9 PF13454.1 EWC44942.1 - 0.056 13.2 0.2 0.33 10.7 0.1 2.1 2 0 0 2 2 2 0 FAD-NAD(P)-binding Amidohydro_1 PF01979.15 EWC44943.1 - 2e-26 93.4 0.0 2.1e-13 50.6 0.0 2.1 2 0 0 2 2 2 2 Amidohydrolase family Amidohydro_4 PF13147.1 EWC44943.1 - 7e-21 75.4 0.0 1.5e-20 74.3 0.0 1.5 1 1 0 1 1 1 1 Amidohydrolase Amidohydro_5 PF13594.1 EWC44943.1 - 5.3e-08 32.5 0.2 1.4e-07 31.2 0.2 1.7 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_3 PF07969.6 EWC44943.1 - 1.8e-07 30.7 0.3 0.0015 17.8 0.0 2.5 2 1 1 3 3 3 2 Amidohydrolase family TatD_DNase PF01026.16 EWC44943.1 - 0.14 11.3 0.0 0.27 10.3 0.0 1.5 2 0 0 2 2 2 0 TatD related DNase UDPGT PF00201.13 EWC44944.1 - 3.4e-08 32.5 0.2 5.5e-08 31.8 0.1 1.3 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_trans_1_4 PF13692.1 EWC44944.1 - 0.013 15.6 0.1 0.033 14.3 0.1 1.7 1 0 0 1 1 1 0 Glycosyl transferases group 1 Glyco_tran_28_C PF04101.11 EWC44944.1 - 0.014 15.0 0.0 0.03 13.9 0.0 1.5 1 0 0 1 1 1 0 Glycosyltransferase family 28 C-terminal domain TPR_11 PF13414.1 EWC44945.1 - 1.5e-10 40.5 1.8 1e-07 31.4 0.1 2.6 1 1 2 3 3 3 2 TPR repeat SET PF00856.23 EWC44945.1 - 3.1e-10 40.5 0.1 3e-09 37.3 0.0 2.4 1 1 0 1 1 1 1 SET domain TPR_14 PF13428.1 EWC44945.1 - 7.3e-05 23.0 5.6 2.4 9.0 0.0 4.8 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.12 EWC44945.1 - 0.00019 21.0 1.2 1.5 8.9 0.0 4.3 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.23 EWC44945.1 - 0.011 15.3 0.1 3.6 7.3 0.0 3.6 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.1 EWC44945.1 - 0.02 15.5 0.2 0.15 12.7 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.1 EWC44945.1 - 0.053 13.8 2.5 1.8 8.9 0.0 3.6 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.1 EWC44945.1 - 0.14 12.0 0.1 0.92 9.4 0.0 2.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.1 EWC44945.1 - 0.91 10.1 3.0 3.4 8.3 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat SET PF00856.23 EWC44946.1 - 5.2e-08 33.3 0.1 8.1e-07 29.4 0.1 2.3 1 1 0 1 1 1 1 SET domain TPR_19 PF14559.1 EWC44946.1 - 0.079 13.3 0.1 0.51 10.7 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat NAD_binding_2 PF03446.10 EWC44947.1 - 8e-27 94.0 0.1 1.2e-26 93.4 0.1 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.1 EWC44947.1 - 1.4e-07 31.6 0.6 2.8e-07 30.6 0.2 1.7 2 0 0 2 2 2 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Shikimate_DH PF01488.15 EWC44947.1 - 4.9e-07 29.9 0.0 7.7e-07 29.2 0.0 1.2 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.12 EWC44947.1 - 1.4e-06 28.6 0.1 3.4e-06 27.4 0.1 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Semialdhyde_dh PF01118.19 EWC44947.1 - 0.0018 18.6 0.0 0.0039 17.4 0.0 1.6 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain OCD_Mu_crystall PF02423.10 EWC44947.1 - 0.0036 16.1 0.0 0.0062 15.3 0.0 1.3 1 0 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family Saccharop_dh PF03435.13 EWC44947.1 - 0.013 14.5 0.1 0.016 14.1 0.1 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase 2-Hacid_dh_C PF02826.14 EWC44947.1 - 0.014 14.5 0.2 0.058 12.5 0.0 1.9 1 1 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GFO_IDH_MocA PF01408.17 EWC44947.1 - 0.039 14.4 0.0 0.091 13.2 0.0 1.8 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold AP_endonuc_2 PF01261.19 EWC44948.1 - 0.099 11.9 0.1 0.17 11.1 0.0 1.4 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel Acetyltransf_1 PF00583.19 EWC44949.1 - 3.7e-14 52.5 0.2 6.3e-14 51.7 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 EWC44949.1 - 2.6e-08 33.9 0.0 4.1e-08 33.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 EWC44949.1 - 2.5e-07 30.7 0.1 4.3e-07 30.0 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 EWC44949.1 - 1.8e-05 24.4 0.1 3.2e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_4 PF13420.1 EWC44949.1 - 0.00053 19.9 0.0 0.0008 19.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.1 EWC44949.1 - 0.0013 18.6 0.0 0.0023 17.7 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_9 PF13527.1 EWC44949.1 - 0.0016 18.3 0.1 0.0034 17.2 0.1 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 EWC44949.1 - 0.0082 16.3 0.0 0.012 15.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 EWC44949.1 - 0.0096 15.8 0.0 0.014 15.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain DUF3749 PF12568.3 EWC44949.1 - 0.017 14.7 0.0 0.024 14.2 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain AMP-binding PF00501.23 EWC44950.1 - 2.2e-79 266.8 0.0 2.5e-79 266.6 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 EWC44950.1 - 8.8e-13 49.0 0.0 2.8e-12 47.4 0.0 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Glyco_hydro_45 PF02015.11 EWC44950.1 - 0.18 11.8 0.0 0.29 11.1 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 45 ELO PF01151.13 EWC44954.1 - 5.3e-77 258.5 5.8 6.2e-77 258.2 4.0 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family EphA2_TM PF14575.1 EWC44955.1 - 0.043 14.2 0.0 0.092 13.1 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DAP10 PF07213.6 EWC44955.1 - 0.09 12.5 0.5 0.21 11.3 0.4 1.6 1 0 0 1 1 1 0 DAP10 membrane protein Adeno_E3_CR2 PF02439.10 EWC44955.1 - 0.15 11.6 0.4 0.39 10.2 0.3 1.7 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Ldr_toxin PF13940.1 EWC44955.1 - 4.2 7.2 5.1 11 5.8 3.5 1.8 1 1 0 1 1 1 0 Toxin Ldr, type I toxin-antitoxin system Herpes_BLLF1 PF05109.8 EWC44955.1 - 5.7 4.7 36.7 9.1 4.1 25.4 1.4 1 0 0 1 1 1 0 Herpes virus major outer envelope glycoprotein (BLLF1) DUF3180 PF11377.3 EWC44956.1 - 0.014 15.2 0.8 0.033 14.0 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3180) ABC2_membrane_2 PF12679.2 EWC44956.1 - 1.6 7.5 9.4 2.8 6.7 5.9 1.8 1 1 1 2 2 2 0 ABC-2 family transporter protein DUF2263 PF10021.4 EWC44957.1 - 1e-20 74.2 0.0 2.2e-20 73.1 0.0 1.6 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2263) Macro PF01661.16 EWC44957.1 - 0.063 13.1 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 Macro domain UPF0126 PF03458.8 EWC44957.1 - 0.1 12.2 0.5 0.37 10.4 0.3 1.9 1 1 0 1 1 1 0 UPF0126 domain ABC_tran PF00005.22 EWC44958.1 - 8.4e-27 94.1 0.0 1.3e-11 44.9 0.0 3.5 2 2 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 EWC44958.1 - 2.7e-16 60.4 0.0 1.1e-05 25.6 0.0 4.1 4 0 0 4 4 4 3 AAA domain SbcCD_C PF13558.1 EWC44958.1 - 3.3e-10 39.7 0.1 3.5e-05 23.6 0.0 2.6 2 1 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.1 EWC44958.1 - 6.6e-07 28.7 0.0 0.0087 15.5 0.0 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.1 EWC44958.1 - 9e-05 22.6 0.1 0.48 10.5 0.0 3.7 3 1 0 3 3 3 1 AAA domain SMC_N PF02463.14 EWC44958.1 - 0.00011 21.5 0.0 2.3 7.3 0.0 3.8 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain MobB PF03205.9 EWC44958.1 - 0.00075 19.2 0.0 0.35 10.5 0.0 2.4 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_23 PF13476.1 EWC44958.1 - 0.0018 18.6 2.5 0.055 13.7 0.7 2.2 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 EWC44958.1 - 0.0022 18.8 0.2 3.2 8.6 0.0 2.9 3 0 0 3 3 2 1 AAA domain DUF258 PF03193.11 EWC44958.1 - 0.0032 16.6 0.0 1.9 7.6 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 NACHT PF05729.7 EWC44958.1 - 0.0072 15.9 0.1 0.92 9.1 0.0 3.1 3 0 0 3 3 3 1 NACHT domain AAA_25 PF13481.1 EWC44958.1 - 0.0096 15.3 0.1 2.8 7.2 0.0 2.9 3 0 0 3 3 3 1 AAA domain AAA_10 PF12846.2 EWC44958.1 - 0.014 14.8 0.4 2.3 7.5 0.0 2.9 3 0 0 3 3 3 0 AAA-like domain IstB_IS21 PF01695.12 EWC44958.1 - 0.015 14.7 0.1 14 5.0 0.0 3.4 4 0 0 4 4 4 0 IstB-like ATP binding protein AAA PF00004.24 EWC44958.1 - 0.021 15.0 0.0 0.92 9.7 0.0 2.7 3 0 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.1 EWC44958.1 - 0.028 14.2 0.3 4.3 7.2 0.0 2.7 2 0 0 2 2 2 0 AAA domain Miro PF08477.8 EWC44958.1 - 0.035 14.6 0.0 7.8 7.0 0.0 2.5 2 0 0 2 2 2 0 Miro-like protein FtsK_SpoIIIE PF01580.13 EWC44958.1 - 0.064 12.7 0.2 4.2 6.8 0.0 2.8 3 0 0 3 3 3 0 FtsK/SpoIIIE family PduV-EutP PF10662.4 EWC44958.1 - 0.066 12.7 0.0 12 5.4 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation MMR_HSR1 PF01926.18 EWC44958.1 - 0.072 13.0 0.0 6.8 6.6 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_18 PF13238.1 EWC44958.1 - 0.1 12.8 0.0 12 6.2 0.0 3.1 4 0 0 4 4 3 0 AAA domain AAA_14 PF13173.1 EWC44958.1 - 0.11 12.4 0.0 16 5.3 0.0 2.9 3 0 0 3 3 3 0 AAA domain DUF2326 PF10088.4 EWC44958.1 - 0.11 12.1 0.0 0.61 9.7 0.0 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2326) Arch_ATPase PF01637.13 EWC44958.1 - 0.11 12.1 0.0 2.4 7.7 0.0 2.6 3 0 0 3 3 3 0 Archaeal ATPase DUF2119 PF09892.4 EWC44958.1 - 0.13 11.4 0.0 0.23 10.7 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2119) RNA_helicase PF00910.17 EWC44958.1 - 0.18 11.9 0.1 16 5.6 0.0 2.4 2 0 0 2 2 2 0 RNA helicase ATP_bind_1 PF03029.12 EWC44958.1 - 0.21 11.0 0.0 22 4.4 0.0 2.3 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_13 PF13166.1 EWC44958.1 - 0.22 9.9 0.0 0.32 9.3 0.0 1.1 1 0 0 1 1 1 0 AAA domain AAA_15 PF13175.1 EWC44958.1 - 0.39 9.7 0.0 25 3.7 0.0 2.7 3 0 0 3 3 3 0 AAA ATPase domain TauD PF02668.11 EWC44959.1 - 1.7e-51 175.3 1.1 2.1e-51 175.0 0.8 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family 2OG-FeII_Oxy_3 PF13640.1 EWC44959.1 - 0.017 15.5 0.1 0.15 12.6 0.0 2.2 2 0 0 2 2 2 0 2OG-Fe(II) oxygenase superfamily ATG_C PF09333.6 EWC44959.1 - 0.027 14.5 0.0 0.051 13.7 0.0 1.4 1 0 0 1 1 1 0 ATG C terminal domain ARD PF03079.9 EWC44960.1 - 2.8e-42 144.3 0.0 3.4e-42 144.0 0.0 1.1 1 0 0 1 1 1 1 ARD/ARD' family Cupin_2 PF07883.6 EWC44960.1 - 1.4e-09 37.3 0.0 3e-09 36.2 0.0 1.5 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.14 EWC44960.1 - 1.2e-05 24.9 0.0 2.2e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_1 PF00190.17 EWC44960.1 - 0.00062 19.2 0.0 0.00087 18.7 0.0 1.2 1 0 0 1 1 1 1 Cupin Cupin_3 PF05899.7 EWC44960.1 - 0.021 14.1 0.0 0.035 13.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF861) Cupin_8 PF13621.1 EWC44960.1 - 0.088 12.2 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 Cupin-like domain PA14_2 PF10528.4 EWC44961.1 - 3.9e-38 129.8 14.3 7.6e-22 77.4 0.5 3.2 3 0 0 3 3 3 2 GLEYA domain PA14 PF07691.7 EWC44961.1 - 7.4e-15 54.8 0.0 9.1e-07 28.6 0.0 2.5 2 0 0 2 2 2 2 PA14 domain C1q PF00386.16 EWC44961.1 - 0.0018 18.2 0.2 0.71 9.8 0.0 2.5 2 0 0 2 2 2 2 C1q domain Tyrosinase PF00264.15 EWC44962.1 - 4.6e-52 177.3 0.0 7.2e-52 176.7 0.0 1.3 1 0 0 1 1 1 1 Common central domain of tyrosinase DUF4130 PF13566.1 EWC44962.1 - 0.15 11.6 0.0 0.27 10.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4130 Phe_hydrox_dim PF07976.7 EWC44962.1 - 0.15 11.6 0.0 0.3 10.6 0.0 1.4 1 0 0 1 1 1 0 Phenol hydroxylase, C-terminal dimerisation domain Asp PF00026.18 EWC44963.1 - 1.3e-38 133.0 0.0 1.7e-38 132.6 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease DUF4328 PF14219.1 EWC44963.1 - 0.097 11.9 0.0 0.19 11.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4328) EphA2_TM PF14575.1 EWC44963.1 - 0.1 13.0 1.1 1.6 9.2 0.0 2.7 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain GRA6 PF05084.8 EWC44963.1 - 0.35 10.3 0.0 0.35 10.3 0.0 2.2 2 0 0 2 2 2 0 Granule antigen protein (GRA6) Tyr-DNA_phospho PF06087.7 EWC44964.1 - 3.4e-86 289.6 0.0 9.8e-49 166.1 0.0 3.1 3 0 0 3 3 3 3 Tyrosyl-DNA phosphodiesterase BTB PF00651.26 EWC44965.1 - 2.6e-06 27.3 0.1 4.7e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Aldedh PF00171.17 EWC44968.1 - 6.3e-20 70.9 6.8 6.5e-15 54.4 2.2 2.2 1 1 1 2 2 2 2 Aldehyde dehydrogenase family zf-C3HC4_2 PF13923.1 EWC44969.1 - 8.5e-08 32.1 5.7 2.1e-07 30.8 3.9 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EWC44969.1 - 2e-06 27.5 8.1 3.6e-06 26.6 5.6 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 EWC44969.1 - 3.2e-06 26.6 6.1 1e-05 25.0 4.2 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EWC44969.1 - 2.7e-05 23.8 7.4 5.2e-05 22.8 5.1 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 EWC44969.1 - 3.8e-05 23.2 6.8 7.8e-05 22.2 4.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 EWC44969.1 - 0.0033 17.2 5.6 0.0033 17.2 3.9 2.2 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 EWC44969.1 - 0.0067 16.1 1.3 0.0067 16.1 0.9 2.2 2 0 0 2 2 2 1 RING-type zinc-finger NB-ARC PF00931.17 EWC44970.1 - 4.2e-11 42.2 0.0 9.3e-11 41.1 0.0 1.6 1 0 0 1 1 1 1 NB-ARC domain AAA_16 PF13191.1 EWC44970.1 - 1.2e-08 35.1 0.0 4.6e-08 33.2 0.0 2.0 1 0 0 1 1 1 1 AAA ATPase domain TPR_12 PF13424.1 EWC44970.1 - 1.6e-06 27.9 2.7 0.0018 18.2 0.0 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat AAA_22 PF13401.1 EWC44970.1 - 0.0068 16.5 0.0 0.031 14.3 0.0 2.2 1 0 0 1 1 1 1 AAA domain Ank_2 PF12796.2 EWC44972.1 - 0.00014 22.1 0.0 0.32 11.3 0.0 2.9 2 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 EWC44972.1 - 0.0008 19.5 0.1 16 5.8 0.0 3.6 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 EWC44972.1 - 0.023 14.8 0.3 16 6.0 0.0 3.5 3 0 0 3 3 3 0 Ankyrin repeat zf-TRAF PF02176.13 EWC44973.1 - 3.1e-10 40.2 26.1 6.7e-06 26.3 5.0 4.4 1 1 4 5 5 5 4 TRAF-type zinc finger zf-C3HC4_2 PF13923.1 EWC44973.1 - 1.1e-06 28.4 7.5 1.1e-06 28.4 5.2 3.8 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EWC44973.1 - 1.8e-06 27.5 4.8 1.8e-06 27.5 3.3 3.1 2 1 1 3 3 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 EWC44973.1 - 4.4e-06 26.2 4.2 4.4e-06 26.2 2.9 3.8 2 1 1 3 3 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EWC44973.1 - 5e-06 26.0 7.3 5e-06 26.0 5.1 3.4 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EWC44973.1 - 2.1e-05 24.2 8.0 2.1e-05 24.2 5.5 3.5 2 1 1 3 3 1 1 Ring finger domain zf-C3HC4_4 PF15227.1 EWC44973.1 - 0.0014 18.4 8.3 0.0014 18.4 5.7 3.6 4 0 0 4 4 4 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 EWC44973.1 - 0.0042 16.7 6.8 0.013 15.2 4.5 2.1 1 1 0 1 1 1 1 RING-type zinc-finger DUF3450 PF11932.3 EWC44973.1 - 0.053 12.7 0.1 0.078 12.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) HALZ PF02183.13 EWC44973.1 - 0.074 12.7 0.2 0.19 11.4 0.2 1.6 1 0 0 1 1 1 0 Homeobox associated leucine zipper U-box PF04564.10 EWC44973.1 - 0.11 12.4 0.6 1.3 8.9 0.1 2.4 2 0 0 2 2 2 0 U-box domain Pox_A_type_inc PF04508.7 EWC44973.1 - 0.86 9.5 2.9 40 4.3 0.0 2.9 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat zf-Di19 PF05605.7 EWC44973.1 - 1.5 9.0 13.6 0.74 9.9 0.6 3.8 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding DUF866 PF05907.8 EWC44974.1 - 2.6e-47 160.2 0.1 2.9e-47 160.1 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF866) PHD PF00628.24 EWC44974.1 - 0.0028 17.2 3.0 0.02 14.5 0.7 2.3 2 0 0 2 2 2 1 PHD-finger Cas_CXXC_CXXC PF09706.5 EWC44974.1 - 0.021 14.9 0.8 1.1 9.4 0.6 2.6 2 1 1 3 3 3 0 CRISPR-associated protein (Cas_CXXC_CXXC) DUF3716 PF12511.3 EWC44974.1 - 0.03 13.9 2.2 0.057 13.0 1.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3716) SprT-like PF10263.4 EWC44974.1 - 0.81 9.3 4.4 3.3 7.3 3.1 1.9 1 1 0 1 1 1 0 SprT-like family zinc_ribbon_4 PF13717.1 EWC44974.1 - 1 9.1 4.5 3.1 7.5 0.3 2.3 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_5 PF13719.1 EWC44974.1 - 1.5 8.4 4.8 3 7.4 0.3 2.3 2 0 0 2 2 2 0 zinc-ribbon domain DUF4379 PF14311.1 EWC44974.1 - 1.6 8.6 5.6 0.28 11.0 1.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4379) Terminase_GpA PF05876.7 EWC44974.1 - 1.6 6.9 4.8 2 6.7 2.6 1.4 1 1 0 1 1 1 0 Phage terminase large subunit (GpA) zf-DNL PF05180.7 EWC44974.1 - 8 6.2 6.8 24 4.7 0.4 2.4 1 1 2 3 3 2 0 DNL zinc finger Zn_Tnp_IS1595 PF12760.2 EWC44974.1 - 9.6 6.1 9.0 73 3.2 5.1 2.8 2 1 1 3 3 3 0 Transposase zinc-ribbon domain PRKCSH-like PF12999.2 EWC44975.1 - 1.7e-47 161.2 1.5 1.7e-47 161.2 1.1 2.2 1 1 1 2 2 2 1 Glucosidase II beta subunit-like PRKCSH_1 PF13015.1 EWC44975.1 - 8.2e-30 103.3 2.7 1.6e-29 102.3 0.2 2.2 2 0 0 2 2 2 1 Glucosidase II beta subunit-like protein PRKCSH PF07915.8 EWC44975.1 - 5.2e-06 27.1 0.3 1.6e-05 25.5 0.2 1.9 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein Tom22 PF04281.8 EWC44975.1 - 0.0049 16.4 1.5 0.076 12.5 0.0 2.9 2 1 1 3 3 3 1 Mitochondrial import receptor subunit Tom22 Moulting_cycle PF04870.11 EWC44975.1 - 0.016 14.3 2.7 0.026 13.5 1.8 1.3 1 0 0 1 1 1 0 Moulting cycle Fmp27_WPPW PF10359.4 EWC44975.1 - 0.03 12.7 2.1 0.056 11.8 1.4 1.3 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain DUF342 PF03961.8 EWC44975.1 - 0.12 10.7 3.6 0.46 8.8 1.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF342) Ldl_recept_a PF00057.13 EWC44975.1 - 0.18 11.6 8.6 0.089 12.7 0.5 2.7 2 0 0 2 2 2 0 Low-density lipoprotein receptor domain class A Prefoldin PF02996.12 EWC44975.1 - 0.19 11.3 5.1 1.2 8.8 0.9 2.6 2 0 0 2 2 2 0 Prefoldin subunit DUF4407 PF14362.1 EWC44975.1 - 0.2 10.6 9.6 0.2 10.5 2.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) LMP PF04778.7 EWC44975.1 - 0.83 9.3 7.3 0.22 11.2 1.7 2.1 2 0 0 2 2 2 0 LMP repeated region TPR_MLP1_2 PF07926.7 EWC44975.1 - 1.1 9.0 11.2 1.7 8.3 0.8 3.2 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein Sec2p PF06428.6 EWC44975.1 - 1.2 9.0 9.0 3.9 7.3 0.0 3.2 3 0 0 3 3 3 0 GDP/GTP exchange factor Sec2p Phage_GP20 PF06810.6 EWC44975.1 - 1.5 8.2 12.7 0.87 9.0 3.9 2.5 2 1 0 2 2 2 0 Phage minor structural protein GP20 Prefoldin_2 PF01920.15 EWC44975.1 - 3.9 7.2 15.2 4.5 7.0 0.0 3.2 3 0 0 3 3 3 0 Prefoldin subunit IncA PF04156.9 EWC44975.1 - 7.4 6.1 11.1 15 5.1 0.0 2.5 2 1 0 2 2 2 0 IncA protein ATP-synt PF00231.14 EWC44978.1 - 0.0025 17.2 1.0 0.0033 16.8 0.7 1.1 1 0 0 1 1 1 1 ATP synthase Trypan_PARP PF05887.6 EWC44979.1 - 2.6 7.8 13.8 5.3 6.8 9.6 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Steroid_dh PF02544.11 EWC44980.1 - 4.9e-28 97.7 0.1 8.3e-28 97.0 0.0 1.4 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase USP7_ICP0_bdg PF12436.3 EWC44980.1 - 0.0047 16.2 0.0 0.0066 15.7 0.0 1.1 1 0 0 1 1 1 1 ICP0-binding domain of Ubiquitin-specific protease 7 DUF1295 PF06966.7 EWC44980.1 - 0.047 12.9 0.1 0.067 12.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1295) ubiquitin PF00240.18 EWC44980.1 - 0.14 11.5 0.0 0.34 10.3 0.0 1.6 1 1 0 1 1 1 0 Ubiquitin family SUR7 PF06687.7 EWC44981.1 - 4.3e-28 98.3 10.3 5.5e-28 97.9 7.2 1.1 1 0 0 1 1 1 1 SUR7/PalI family CorA PF01544.13 EWC44981.1 - 6 5.8 3.8 8.3 5.3 2.6 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein BPD_transp_1 PF00528.17 EWC44981.1 - 8 5.9 11.6 0.19 11.2 3.4 1.6 2 0 0 2 2 2 0 Binding-protein-dependent transport system inner membrane component Amidohydro_4 PF13147.1 EWC44983.1 - 4.6e-14 53.1 0.3 6.9e-08 32.8 0.0 2.3 2 1 0 2 2 2 2 Amidohydrolase Amidohydro_1 PF01979.15 EWC44983.1 - 1.1e-10 41.7 0.0 3.9e-10 39.8 0.0 1.8 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.6 EWC44983.1 - 3.1e-07 29.9 0.1 6.6e-07 28.8 0.0 1.6 2 0 0 2 2 2 1 Amidohydrolase family Amidohydro_5 PF13594.1 EWC44983.1 - 1.6e-05 24.6 0.0 5.5e-05 22.8 0.0 1.9 2 0 0 2 2 2 1 Amidohydrolase LURAP PF14854.1 EWC44983.1 - 0.25 11.0 0.8 0.7 9.6 0.0 2.0 2 0 0 2 2 2 0 Leucine rich adaptor protein RR_TM4-6 PF06459.7 EWC44984.1 - 0.025 14.4 6.3 0.036 13.9 4.3 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 VID27 PF08553.5 EWC44984.1 - 1.3 7.1 4.8 1.8 6.6 3.3 1.1 1 0 0 1 1 1 0 VID27 cytoplasmic protein PBP1_TM PF14812.1 EWC44984.1 - 4.4 7.6 7.2 3.7 7.9 3.4 2.1 1 1 1 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal ACBP PF00887.14 EWC44985.1 - 3.1e-30 103.6 0.1 3.3e-30 103.5 0.0 1.0 1 0 0 1 1 1 1 Acyl CoA binding protein HD_3 PF13023.1 EWC44986.1 - 3.7e-41 140.6 0.2 4.6e-41 140.3 0.1 1.1 1 0 0 1 1 1 1 HD domain HD PF01966.17 EWC44986.1 - 3.4e-07 30.2 0.0 5.5e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 HD domain CO_deh_flav_C PF03450.12 EWC44986.1 - 0.11 12.3 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 CO dehydrogenase flavoprotein C-terminal domain SNARE_assoc PF09335.6 EWC44987.1 - 1.7e-10 41.1 6.0 1.7e-10 41.1 4.2 2.0 2 1 0 2 2 2 1 SNARE associated Golgi protein PBP1_TM PF14812.1 EWC44989.1 - 0.02 15.2 6.5 0.02 15.2 4.5 6.1 5 1 1 6 6 6 0 Transmembrane domain of transglycosylase PBP1 at N-terminal ETRAMP PF09716.5 EWC44989.1 - 0.095 12.6 0.1 7.6 6.5 0.0 3.0 3 0 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) p450 PF00067.17 EWC44990.1 - 1.7e-61 208.1 0.0 2.2e-61 207.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 RTA1 PF04479.8 EWC44991.1 - 1.3e-40 139.3 5.2 1.3e-40 139.3 3.6 1.3 2 0 0 2 2 2 1 RTA1 like protein UNC-50 PF05216.8 EWC44991.1 - 0.012 14.7 3.7 0.022 13.9 0.0 2.2 2 0 0 2 2 2 0 UNC-50 family Spt20 PF12090.3 EWC44992.1 - 0.2 10.9 3.1 6.7 6.0 0.1 2.3 2 0 0 2 2 2 0 Spt20 family DUF2418 PF10332.4 EWC44993.1 - 6.8e-21 74.4 2.4 1.7e-20 73.1 1.7 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF2418) YtpI PF14007.1 EWC44993.1 - 0.2 11.5 2.4 7.9 6.4 0.2 2.6 2 0 0 2 2 2 0 YtpI-like protein NUDIX PF00293.23 EWC44994.1 - 5.4e-18 64.9 0.1 8.9e-18 64.2 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain NUDIX-like PF09296.6 EWC44994.1 - 7.6e-08 32.6 0.6 2.3e-07 31.0 0.2 2.0 2 0 0 2 2 2 1 NADH pyrophosphatase-like rudimentary NUDIX domain zf-NADH-PPase PF09297.6 EWC44994.1 - 2.8e-06 26.7 3.4 4.8e-06 25.9 2.3 1.3 1 0 0 1 1 1 1 NADH pyrophosphatase zinc ribbon domain zf-ribbon_3 PF13248.1 EWC44994.1 - 0.05 12.8 0.2 0.11 11.7 0.1 1.5 1 0 0 1 1 1 0 zinc-ribbon domain Exo_endo_phos PF03372.18 EWC44995.1 - 1.7e-20 74.0 0.1 3.4e-20 73.0 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family BBS2_Mid PF14783.1 EWC44995.1 - 0.021 14.5 0.3 0.17 11.6 0.0 2.6 2 1 1 3 3 3 0 Ciliary BBSome complex subunit 2, middle region MARVEL PF01284.18 EWC44996.1 - 0.01 15.6 9.3 0.02 14.6 6.4 1.5 1 1 0 1 1 1 0 Membrane-associating domain DUF996 PF06195.8 EWC44996.1 - 0.011 15.7 5.0 0.49 10.3 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF996) AgrB PF04647.10 EWC44996.1 - 0.3 10.1 3.6 0.67 8.9 0.0 2.7 3 1 0 3 3 3 0 Accessory gene regulator B zf-CHY PF05495.7 EWC44997.1 - 1.4e-15 57.2 14.9 1.9e-15 56.7 10.4 1.2 1 0 0 1 1 1 1 CHY zinc finger HypA PF01155.14 EWC44997.1 - 0.0095 15.6 2.0 0.0095 15.6 1.4 2.2 1 1 1 2 2 2 1 Hydrogenase expression/synthesis hypA family zinc_ribbon_2 PF13240.1 EWC44997.1 - 0.021 14.2 8.5 0.17 11.4 0.3 3.2 3 0 0 3 3 3 0 zinc-ribbon domain zf-ribbon_3 PF13248.1 EWC44997.1 - 0.056 12.6 5.6 0.18 11.0 1.1 2.5 2 0 0 2 2 2 0 zinc-ribbon domain DRP PF06044.7 EWC44997.1 - 0.099 11.6 4.3 0.068 12.1 0.8 1.9 1 1 1 2 2 2 0 Dam-replacing family zf-C2H2 PF00096.21 EWC44997.1 - 0.099 13.0 7.5 3.6 8.1 0.4 3.5 3 0 0 3 3 3 0 Zinc finger, C2H2 type DZR PF12773.2 EWC44997.1 - 0.18 11.6 9.4 0.92 9.3 6.5 2.3 1 1 0 1 1 1 0 Double zinc ribbon zinc-ribbons_6 PF07191.7 EWC44997.1 - 0.19 11.5 10.0 0.66 9.8 1.9 2.7 1 1 2 3 3 3 0 zinc-ribbons RNA_POL_M_15KD PF02150.11 EWC44997.1 - 0.34 10.6 4.0 20 4.9 0.0 2.9 2 1 1 3 3 3 0 RNA polymerases M/15 Kd subunit Elf1 PF05129.8 EWC44997.1 - 0.39 10.4 9.0 2.6 7.7 6.2 2.0 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like Trm112p PF03966.11 EWC44997.1 - 0.53 10.6 3.3 1.3 9.4 0.5 2.4 2 1 0 2 2 2 0 Trm112p-like protein NOB1_Zn_bind PF08772.6 EWC44997.1 - 0.61 9.9 5.4 0.17 11.7 1.4 2.0 1 1 1 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like Cys_rich_KTR PF14205.1 EWC44997.1 - 0.67 9.4 8.9 7.6 6.0 0.1 2.8 1 1 1 2 2 2 0 Cysteine-rich KTR Zn_Tnp_IS1595 PF12760.2 EWC44997.1 - 0.79 9.5 11.7 4.7 7.1 3.0 3.0 3 1 0 3 3 3 0 Transposase zinc-ribbon domain PhnA_Zn_Ribbon PF08274.7 EWC44997.1 - 0.97 9.2 7.1 21 5.0 0.0 3.1 2 1 0 2 2 2 0 PhnA Zinc-Ribbon Zn-ribbon_8 PF09723.5 EWC44997.1 - 1.2 9.1 15.1 1 9.3 3.5 2.5 1 1 0 2 2 2 0 Zinc ribbon domain Evr1_Alr PF04777.8 EWC44997.1 - 1.2 9.0 6.2 2.4 8.1 1.9 2.3 1 1 1 2 2 2 0 Erv1 / Alr family Terminase_GpA PF05876.7 EWC44997.1 - 1.5 7.1 4.7 1.5 7.0 3.3 1.1 1 0 0 1 1 1 0 Phage terminase large subunit (GpA) zinc_ribbon_5 PF13719.1 EWC44997.1 - 1.7 8.2 13.6 9.3 5.9 0.6 3.7 2 2 1 3 3 3 0 zinc-ribbon domain zf-C2H2_4 PF13894.1 EWC44997.1 - 2.1 8.8 6.8 91 3.7 0.0 3.8 3 1 0 3 3 3 0 C2H2-type zinc finger DUF2296 PF10058.4 EWC44997.1 - 2.2 8.1 7.6 0.52 10.1 1.4 2.4 1 1 0 2 2 2 0 Predicted integral membrane metal-binding protein (DUF2296) zinc_ribbon_4 PF13717.1 EWC44997.1 - 2.3 8.0 13.8 9.9 5.9 0.1 3.6 2 1 1 3 3 3 0 zinc-ribbon domain DUF3797 PF12677.2 EWC44997.1 - 2.5 7.8 7.8 2.7 7.6 0.0 3.0 1 1 0 2 2 2 0 Domain of unknown function (DUF3797) zf-H2C2_2 PF13465.1 EWC44997.1 - 3.9 7.9 11.5 5.1 7.5 0.3 3.4 3 1 0 3 3 3 0 Zinc-finger double domain TFIIS_C PF01096.13 EWC44997.1 - 4.7 6.9 8.9 9.3 5.9 0.2 3.4 3 0 0 3 3 3 0 Transcription factor S-II (TFIIS) zf-RING_3 PF14369.1 EWC44997.1 - 7.3 6.6 11.6 0.89 9.6 1.8 3.0 2 1 1 3 3 3 0 zinc-finger C1_4 PF07975.7 EWC44997.1 - 9.4 6.3 11.5 2.1 8.4 2.6 2.5 1 1 0 2 2 2 0 TFIIH C1-like domain Proteasome PF00227.21 EWC44998.1 - 9.3e-56 188.1 0.0 1.5e-55 187.4 0.0 1.3 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 EWC44998.1 - 2.6e-13 49.0 0.1 2.6e-13 49.0 0.0 1.8 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature Ino80_Iec3 PF14612.1 EWC44998.1 - 0.11 12.5 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 IEC3 subunit of the Ino80 complex, chromatin re-modelling FAD-oxidase_C PF02913.14 EWC44999.1 - 2.8e-54 184.0 0.0 3.7e-54 183.6 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.18 EWC44999.1 - 4.1e-35 120.2 0.3 7.3e-35 119.4 0.2 1.4 1 0 0 1 1 1 1 FAD binding domain WD40 PF00400.27 EWC45000.1 - 4.4e-35 118.2 12.4 4.2e-08 32.7 0.1 7.6 7 1 0 7 7 7 6 WD domain, G-beta repeat PQQ_3 PF13570.1 EWC45000.1 - 1.5e-07 31.4 5.8 0.029 14.6 0.0 5.2 5 1 0 5 5 5 2 PQQ-like domain PQQ_2 PF13360.1 EWC45000.1 - 1.1e-05 24.9 3.4 0.0005 19.6 1.4 2.4 1 1 1 2 2 2 2 PQQ-like domain BBS2_Mid PF14783.1 EWC45000.1 - 0.00039 20.1 0.0 5.8 6.7 0.0 4.0 4 0 0 4 4 4 2 Ciliary BBSome complex subunit 2, middle region Nup160 PF11715.3 EWC45000.1 - 0.0042 15.2 0.6 4.6 5.2 0.1 3.3 1 1 2 3 3 3 2 Nucleoporin Nup120/160 Gmad1 PF10647.4 EWC45000.1 - 0.015 14.6 1.4 0.083 12.2 0.0 2.2 2 0 0 2 2 2 0 Lipoprotein LpqB beta-propeller domain Kelch_6 PF13964.1 EWC45000.1 - 0.016 15.3 0.2 0.25 11.5 0.0 2.9 2 0 0 2 2 2 0 Kelch motif SKIP_SNW PF02731.10 EWC45001.1 - 1.6e-67 225.8 2.2 1.6e-67 225.8 1.5 2.4 2 0 0 2 2 2 1 SKIP/SNW domain Nucleo_P87 PF07267.6 EWC45001.1 - 9.8 4.7 7.8 16 4.0 5.4 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 BCDHK_Adom3 PF10436.4 EWC45002.1 - 2e-41 141.2 0.0 3.5e-41 140.4 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.21 EWC45002.1 - 6.9e-11 41.8 0.0 3e-10 39.7 0.0 1.9 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.1 EWC45002.1 - 0.0025 17.4 0.0 0.0043 16.7 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase USP7_ICP0_bdg PF12436.3 EWC45003.1 - 1.2e-77 260.5 0.0 4.9e-77 258.5 0.0 2.0 2 0 0 2 2 2 1 ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 PF14533.1 EWC45003.1 - 1.1e-70 237.3 3.0 5.7e-68 228.5 1.3 3.3 3 0 0 3 3 3 2 Ubiquitin-specific protease C-terminal UCH PF00443.24 EWC45003.1 - 1.8e-53 181.3 0.1 3.7e-53 180.3 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 EWC45003.1 - 2.1e-31 109.4 0.0 7.6e-31 107.6 0.0 1.8 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase MATH PF00917.21 EWC45003.1 - 3.1e-09 37.0 0.0 1.7e-08 34.7 0.0 2.4 1 0 0 1 1 1 1 MATH domain DUF1308 PF07000.6 EWC45003.1 - 0.03 12.9 0.1 3.4 6.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1308) YukD PF08817.5 EWC45003.1 - 0.084 13.4 0.0 3.2 8.3 0.0 2.8 2 0 0 2 2 2 0 WXG100 protein secretion system (Wss), protein YukD EMP24_GP25L PF01105.19 EWC45004.1 - 1.3e-42 145.6 1.6 1.6e-42 145.2 1.1 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Peptidase_C48 PF02902.14 EWC45005.1 - 1.2e-38 132.8 0.0 2.1e-38 132.1 0.0 1.3 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain HDA2-3 PF11496.3 EWC45006.1 - 8.8e-20 70.7 0.0 2.8e-19 69.0 0.0 1.8 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 Tropomyosin_1 PF12718.2 EWC45006.1 - 0.0017 18.2 10.7 0.0017 18.2 7.4 3.2 1 1 2 3 3 3 1 Tropomyosin like HR1 PF02185.11 EWC45006.1 - 0.01 15.5 2.4 0.01 15.5 1.6 3.4 3 0 0 3 3 3 0 Hr1 repeat KRAB PF01352.22 EWC45006.1 - 0.037 13.4 0.1 0.073 12.5 0.1 1.4 1 0 0 1 1 1 0 KRAB box TMPIT PF07851.8 EWC45006.1 - 0.097 11.7 2.7 0.22 10.5 1.9 1.5 1 0 0 1 1 1 0 TMPIT-like protein Fib_alpha PF08702.5 EWC45006.1 - 0.14 12.2 11.1 0.37 10.9 0.4 2.8 3 0 0 3 3 2 0 Fibrinogen alpha/beta chain family TPR_MLP1_2 PF07926.7 EWC45006.1 - 0.44 10.2 20.8 0.14 11.8 3.7 3.5 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein MAD PF05557.8 EWC45006.1 - 0.59 8.1 26.0 1.7 6.6 17.8 1.8 2 1 0 2 2 2 0 Mitotic checkpoint protein Nup54 PF13874.1 EWC45006.1 - 0.87 9.2 14.4 0.081 12.5 2.9 3.1 1 1 2 3 3 3 0 Nucleoporin complex subunit 54 STAT_alpha PF01017.15 EWC45006.1 - 1 9.0 8.4 0.34 10.6 1.3 2.4 1 1 1 2 2 2 0 STAT protein, all-alpha domain DUF4140 PF13600.1 EWC45006.1 - 2.2 8.7 20.6 4.3 7.8 2.8 4.9 4 1 0 4 4 4 0 N-terminal domain of unknown function (DUF4140) Exonuc_VII_L PF02601.10 EWC45006.1 - 5.5 6.0 12.0 13 4.8 8.3 1.6 1 0 0 1 1 1 0 Exonuclease VII, large subunit Atg14 PF10186.4 EWC45006.1 - 7.6 5.3 16.7 0.36 9.7 3.7 2.5 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 FMO-like PF00743.14 EWC45007.1 - 5.7e-46 156.8 0.1 4.2e-22 78.0 0.1 3.0 3 0 0 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.1 EWC45007.1 - 3.5e-17 63.1 0.0 2.6e-16 60.3 0.0 2.3 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 EWC45007.1 - 3e-12 46.8 0.0 1.2e-11 44.8 0.0 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 EWC45007.1 - 1.4e-09 37.3 2.4 3.8e-08 32.6 0.2 2.7 2 1 1 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.1 EWC45007.1 - 3.3e-08 33.4 0.0 9.1e-07 28.7 0.0 2.7 2 1 0 2 2 2 1 FAD-NAD(P)-binding Thi4 PF01946.12 EWC45007.1 - 4.2e-06 26.0 0.1 0.0017 17.4 0.0 2.2 2 0 0 2 2 2 2 Thi4 family NAD_binding_8 PF13450.1 EWC45007.1 - 5e-06 26.4 0.0 1.1e-05 25.3 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.9 EWC45007.1 - 8.2e-05 21.2 0.7 0.022 13.2 0.1 2.4 3 0 0 3 3 3 2 HI0933-like protein Pyr_redox PF00070.22 EWC45007.1 - 0.0017 18.7 0.0 0.9 9.9 0.0 2.9 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Mqo PF06039.10 EWC45007.1 - 0.0055 14.9 0.0 0.0085 14.3 0.0 1.2 1 0 0 1 1 1 1 Malate:quinone oxidoreductase (Mqo) FAD_binding_3 PF01494.14 EWC45007.1 - 0.0069 15.4 0.1 0.015 14.3 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.2 EWC45007.1 - 0.0081 15.2 0.1 0.019 14.0 0.1 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO PF01266.19 EWC45007.1 - 0.0082 15.0 0.0 0.056 12.3 0.0 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase Amino_oxidase PF01593.19 EWC45007.1 - 0.055 12.5 0.0 8.6 5.2 0.0 2.2 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase FAD_binding_2 PF00890.19 EWC45007.1 - 0.088 11.6 0.0 0.2 10.4 0.0 1.5 2 0 0 2 2 2 0 FAD binding domain POT1 PF02765.12 EWC45009.1 - 5.8e-05 23.0 0.0 0.00011 22.1 0.0 1.4 1 0 0 1 1 1 1 Telomeric single stranded DNA binding POT1/CDC13 Spore_coat_CotO PF14153.1 EWC45009.1 - 0.14 11.5 13.6 0.33 10.3 9.4 1.6 1 0 0 1 1 1 0 Spore coat protein CotO BUD22 PF09073.5 EWC45009.1 - 0.32 10.0 27.4 0.87 8.5 19.0 1.8 1 0 0 1 1 1 0 BUD22 DUF1510 PF07423.6 EWC45009.1 - 3.5 6.9 23.4 5.3 6.3 15.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1510) DDHD PF02862.12 EWC45009.1 - 9.8 5.8 10.1 2.3 7.9 4.2 2.1 2 0 0 2 2 2 0 DDHD domain SH3_2 PF07653.12 EWC45010.1 - 5.7e-09 35.3 0.2 1.1e-08 34.4 0.2 1.5 1 0 0 1 1 1 1 Variant SH3 domain Transglut_core PF01841.14 EWC45010.1 - 2.8e-08 33.9 0.1 5.8e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 Transglutaminase-like superfamily SH3_1 PF00018.23 EWC45010.1 - 5.9e-08 31.9 0.1 1.3e-07 30.8 0.1 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 EWC45010.1 - 7.8e-06 25.3 0.1 1.5e-05 24.4 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain AIG2 PF06094.7 EWC45011.1 - 1.9e-14 53.9 0.0 2.8e-14 53.4 0.0 1.2 1 0 0 1 1 1 1 AIG2-like family COG2 PF06148.6 EWC45012.1 - 8.6e-32 109.8 0.2 2.2e-31 108.4 0.0 1.7 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 Vps51 PF08700.6 EWC45012.1 - 0.0081 15.9 0.1 0.025 14.4 0.0 1.9 2 0 0 2 2 2 1 Vps51/Vps67 DUF1045 PF06299.7 EWC45012.1 - 0.01 15.5 0.1 0.025 14.2 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1045) Ribosomal_L1 PF00687.16 EWC45013.1 - 1.8e-28 99.3 0.0 2.4e-28 98.9 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family SRP54 PF00448.17 EWC45014.1 - 2e-76 255.8 2.2 2.1e-76 255.7 0.8 1.5 2 0 0 2 2 1 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.14 EWC45014.1 - 1.6e-25 89.3 5.7 1.6e-25 89.3 4.0 3.5 5 0 0 5 5 3 1 Signal peptide binding domain SRP54_N PF02881.14 EWC45014.1 - 8.1e-15 54.6 0.6 1.8e-14 53.5 0.4 1.6 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain cobW PF02492.14 EWC45014.1 - 3.8e-08 32.9 0.1 1.1e-07 31.4 0.1 1.8 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.1 EWC45014.1 - 2.7e-07 30.5 0.1 6.2e-07 29.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain MobB PF03205.9 EWC45014.1 - 2.1e-06 27.5 0.0 6.8e-06 25.8 0.0 1.9 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_22 PF13401.1 EWC45014.1 - 0.00018 21.6 0.1 0.0006 19.9 0.0 2.0 2 0 0 2 2 1 1 AAA domain CbiA PF01656.18 EWC45014.1 - 0.00025 20.5 0.1 0.00088 18.7 0.1 1.9 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_17 PF13207.1 EWC45014.1 - 0.00035 21.3 0.0 0.00072 20.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 EWC45014.1 - 0.0025 16.9 0.0 0.0074 15.3 0.0 1.8 1 0 0 1 1 1 1 Zeta toxin Thymidylate_kin PF02223.12 EWC45014.1 - 0.0032 16.8 0.2 0.012 14.9 0.0 2.1 2 0 0 2 2 2 1 Thymidylate kinase APS_kinase PF01583.15 EWC45014.1 - 0.0032 17.1 0.0 0.0068 16.0 0.0 1.5 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_31 PF13614.1 EWC45014.1 - 0.0042 17.0 0.0 0.92 9.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.1 EWC45014.1 - 0.0053 17.0 0.0 0.017 15.4 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_10 PF12846.2 EWC45014.1 - 0.0075 15.7 0.0 0.012 15.1 0.0 1.3 1 0 0 1 1 1 1 AAA-like domain TrwB_AAD_bind PF10412.4 EWC45014.1 - 0.0076 14.9 0.0 0.016 13.8 0.0 1.5 1 0 0 1 1 1 1 Type IV secretion-system coupling protein DNA-binding domain 6PF2K PF01591.13 EWC45014.1 - 0.011 14.8 0.0 0.018 14.1 0.0 1.3 1 0 0 1 1 1 0 6-phosphofructo-2-kinase SRPRB PF09439.5 EWC45014.1 - 0.013 14.6 1.1 1.2 8.3 0.1 2.9 2 1 1 3 3 3 0 Signal recognition particle receptor beta subunit ATP_bind_1 PF03029.12 EWC45014.1 - 0.017 14.6 1.6 0.046 13.2 0.0 2.5 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein AAA_19 PF13245.1 EWC45014.1 - 0.042 13.5 0.3 0.22 11.2 0.0 2.3 2 0 0 2 2 2 0 Part of AAA domain TraC PF07820.7 EWC45014.1 - 0.055 13.6 0.2 0.16 12.1 0.1 1.8 1 0 0 1 1 1 0 TraC-like protein AAA_16 PF13191.1 EWC45014.1 - 0.082 12.8 0.0 0.27 11.2 0.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain KduI PF04962.7 EWC45014.1 - 0.1 11.6 0.2 4.7 6.2 0.0 2.3 2 0 0 2 2 2 0 KduI/IolB family AAA_28 PF13521.1 EWC45014.1 - 0.11 12.4 0.1 0.24 11.3 0.1 1.7 1 1 0 1 1 1 0 AAA domain LysR_substrate PF03466.15 EWC45015.1 - 0.071 12.2 0.0 0.65 9.0 0.0 2.0 2 0 0 2 2 2 0 LysR substrate binding domain NMT1 PF09084.6 EWC45015.1 - 0.11 12.0 0.0 4.8 6.7 0.0 2.2 2 0 0 2 2 2 0 NMT1/THI5 like CTD_bind PF04818.8 EWC45016.1 - 0.00066 19.8 0.0 0.0015 18.6 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase II-binding domain. DUF936 PF06075.7 EWC45016.1 - 0.14 11.1 24.6 0.18 10.7 17.1 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) MIP-T3 PF10243.4 EWC45016.1 - 6.7 5.0 40.3 9.5 4.5 27.9 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Pmp3 PF01679.12 EWC45018.1 - 1e-19 69.9 9.7 1.6e-19 69.3 6.7 1.3 1 0 0 1 1 1 1 Proteolipid membrane potential modulator RRM_6 PF14259.1 EWC45019.1 - 8.1e-22 76.9 0.0 9.2e-08 31.9 0.0 4.2 4 0 0 4 4 4 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 EWC45019.1 - 2.5e-20 71.8 0.1 1.2e-10 40.8 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EWC45019.1 - 2.2e-12 46.6 0.6 9.4e-05 22.1 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) BRAP2 PF07576.7 EWC45019.1 - 0.33 10.5 0.0 0.67 9.5 0.0 1.5 1 0 0 1 1 1 0 BRCA1-associated protein 2 ACT_7 PF13840.1 EWC45020.1 - 6.2e-24 83.2 0.0 1.5e-16 59.6 0.0 2.4 2 0 0 2 2 2 2 ACT domain Myf5 PF12232.3 EWC45020.1 - 3.6 8.2 7.0 0.64 10.6 1.5 2.2 2 0 0 2 2 2 0 Myogenic determination factor 5 SPC22 PF04573.7 EWC45021.1 - 3.4e-40 137.1 0.4 3.7e-40 136.9 0.3 1.0 1 0 0 1 1 1 1 Signal peptidase subunit XRN_N PF03159.13 EWC45022.1 - 6.7e-102 339.9 0.0 1e-101 339.3 0.0 1.3 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus WD40 PF00400.27 EWC45023.1 - 4e-39 131.1 5.7 2.1e-07 30.5 0.1 6.3 6 0 0 6 6 6 5 WD domain, G-beta repeat CAF1C_H4-bd PF12265.3 EWC45023.1 - 2.1e-28 97.9 0.1 5.1e-28 96.7 0.0 1.7 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex eIF2A PF08662.6 EWC45023.1 - 9e-05 22.2 0.2 0.047 13.4 0.0 2.8 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A SEP PF08059.8 EWC45024.1 - 1.3e-26 92.7 0.0 3.6e-26 91.2 0.0 1.8 1 0 0 1 1 1 1 SEP domain UBX PF00789.15 EWC45024.1 - 1.2e-18 66.9 0.0 2.5e-18 65.8 0.0 1.6 1 0 0 1 1 1 1 UBX domain UBA_4 PF14555.1 EWC45024.1 - 1.5e-11 43.6 0.0 2.4e-11 42.9 0.0 1.3 1 0 0 1 1 1 1 UBA-like domain ADK PF00406.17 EWC45025.1 - 5.2e-62 208.1 0.0 6.5e-62 207.8 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase ADK_lid PF05191.9 EWC45025.1 - 4.9e-14 51.7 0.0 1.3e-13 50.3 0.0 1.7 2 0 0 2 2 2 1 Adenylate kinase, active site lid AAA_17 PF13207.1 EWC45025.1 - 3.3e-05 24.6 0.0 7e-05 23.6 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.1 EWC45025.1 - 0.00042 20.2 0.0 0.00073 19.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 EWC45025.1 - 0.0043 16.1 0.0 0.0061 15.6 0.0 1.2 1 0 0 1 1 1 1 Zeta toxin AAA_18 PF13238.1 EWC45025.1 - 0.0064 16.8 0.0 0.013 15.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain CFIA_Pcf11 PF11526.3 EWC45026.1 - 8.6e-08 32.2 0.6 3.2e-07 30.3 0.4 2.0 1 0 0 1 1 1 1 Subunit of cleavage factor IA Pcf11 VHS PF00790.14 EWC45026.1 - 0.00062 19.4 0.0 0.0017 17.9 0.0 1.7 1 0 0 1 1 1 1 VHS domain CTD_bind PF04818.8 EWC45026.1 - 0.0059 16.8 0.0 0.02 15.0 0.0 2.0 1 0 0 1 1 1 1 RNA polymerase II-binding domain. zf-H2C2_2 PF13465.1 EWC45026.1 - 0.76 10.1 4.3 8.1 6.9 0.0 3.2 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2H2_4 PF13894.1 EWC45026.1 - 1.1 9.8 5.0 3.9 8.0 0.5 3.1 3 0 0 3 3 3 0 C2H2-type zinc finger Mito_carr PF00153.22 EWC45027.1 - 7.8e-29 99.2 1.0 6.5e-15 54.6 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein IGPS PF00218.16 EWC45028.1 - 8.1e-96 319.9 0.1 2e-95 318.6 0.0 1.7 2 0 0 2 2 2 1 Indole-3-glycerol phosphate synthase GATase PF00117.23 EWC45028.1 - 4.4e-49 166.5 0.0 8.5e-49 165.6 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase class-I PRAI PF00697.17 EWC45028.1 - 1.1e-46 158.8 0.0 1.4e-44 152.0 0.0 2.2 1 1 1 2 2 2 2 N-(5'phosphoribosyl)anthranilate (PRA) isomerase Peptidase_C26 PF07722.8 EWC45028.1 - 3.8e-06 26.5 0.2 3.1e-05 23.5 0.1 2.3 1 1 0 1 1 1 1 Peptidase C26 QRPTase_C PF01729.14 EWC45028.1 - 0.041 13.3 0.1 0.14 11.6 0.0 1.9 2 0 0 2 2 2 0 Quinolinate phosphoribosyl transferase, C-terminal domain FMN_dh PF01070.13 EWC45028.1 - 0.049 12.4 0.5 0.25 10.1 0.1 2.0 2 0 0 2 2 2 0 FMN-dependent dehydrogenase Nup188 PF10487.4 EWC45029.1 - 3.2e-56 190.8 0.0 2.5e-54 184.6 0.0 2.2 2 0 0 2 2 2 2 Nucleoporin subcomplex protein binding to Pom34 PI-PLC-X PF00388.14 EWC45030.1 - 8e-58 193.9 0.0 1.5e-57 193.0 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.14 EWC45030.1 - 3.2e-40 136.8 0.0 6.7e-40 135.7 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.25 EWC45030.1 - 5.3e-10 39.0 0.0 2e-09 37.1 0.0 2.0 1 0 0 1 1 1 1 C2 domain EF-hand_like PF09279.6 EWC45030.1 - 9.7e-07 28.7 0.5 4e-05 23.5 0.0 2.5 2 0 0 2 2 2 1 Phosphoinositide-specific phospholipase C, efhand-like EF-hand_10 PF14788.1 EWC45030.1 - 4.2e-05 23.1 0.2 9.3e-05 22.0 0.1 1.6 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.1 EWC45030.1 - 0.0031 17.2 0.7 0.026 14.4 0.1 2.8 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.27 EWC45030.1 - 0.012 14.8 1.0 0.06 12.6 0.0 2.7 3 0 0 3 3 3 0 EF hand EF-hand_7 PF13499.1 EWC45030.1 - 0.045 13.8 1.5 0.14 12.3 0.1 2.4 2 1 1 3 3 3 0 EF-hand domain pair HAD_2 PF13419.1 EWC45031.1 - 1.3e-19 71.0 0.0 3.9e-19 69.5 0.0 1.7 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 EWC45031.1 - 0.023 15.1 0.0 0.12 12.7 0.0 1.9 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 EWC45031.1 - 0.045 13.4 0.0 0.083 12.6 0.0 1.4 1 0 0 1 1 1 0 HAD-hyrolase-like Brix PF04427.13 EWC45032.1 - 2.1e-44 151.4 0.1 2.6e-44 151.1 0.1 1.1 1 0 0 1 1 1 1 Brix domain Ribosomal_L18p PF00861.17 EWC45033.1 - 1e-42 145.1 0.1 1.9e-42 144.2 0.1 1.5 1 0 0 1 1 1 1 Ribosomal L18p/L5e family Ribosomal_L18_c PF14204.1 EWC45033.1 - 1.2e-32 112.3 5.3 1.2e-32 112.3 3.7 1.7 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region Thr_synth_N PF14821.1 EWC45033.1 - 0.041 13.9 0.1 0.72 9.9 0.0 2.6 2 0 0 2 2 2 0 Threonine synthase N terminus XPG_N PF00752.12 EWC45034.1 - 1.1e-31 109.0 0.3 3.2e-31 107.5 0.0 1.9 2 0 0 2 2 2 1 XPG N-terminal domain XPG_I PF00867.13 EWC45034.1 - 1.6e-30 105.0 1.0 4.6e-30 103.5 0.1 2.2 2 0 0 2 2 2 1 XPG I-region 5_3_exonuc PF01367.15 EWC45034.1 - 2.2e-06 27.7 2.8 2.8e-06 27.4 0.0 2.5 3 0 0 3 3 3 1 5'-3' exonuclease, C-terminal SAM fold HHH_2 PF12826.2 EWC45034.1 - 0.047 13.5 0.0 0.12 12.2 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix motif Acyl-CoA_dh_1 PF00441.19 EWC45035.1 - 2.6e-22 79.5 0.0 3.7e-22 79.0 0.0 1.1 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.14 EWC45035.1 - 4.2e-18 64.5 0.0 7e-18 63.8 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.6 EWC45035.1 - 1.4e-06 28.5 0.1 2.8e-06 27.6 0.1 1.5 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.11 EWC45035.1 - 0.1 13.1 0.0 0.21 12.1 0.0 1.6 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, N-terminal domain UQ_con PF00179.21 EWC45036.1 - 3.1e-51 172.5 0.0 3.4e-51 172.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 EWC45036.1 - 0.0002 21.0 0.0 0.00024 20.8 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 EWC45036.1 - 0.0051 16.6 0.0 0.0056 16.5 0.0 1.2 1 0 0 1 1 1 1 RWD domain UEV PF05743.8 EWC45036.1 - 0.02 14.5 0.0 0.031 13.9 0.0 1.3 1 0 0 1 1 1 0 UEV domain TLD PF07534.11 EWC45037.1 - 6.8e-33 113.5 0.0 8.9e-33 113.2 0.0 1.1 1 0 0 1 1 1 1 TLD Sel1 PF08238.7 EWC45038.1 - 4.4e-17 62.1 17.3 2.1e-06 28.1 0.0 7.1 7 0 0 7 7 7 5 Sel1 repeat TPR_1 PF00515.23 EWC45038.1 - 0.0005 19.5 0.5 0.0089 15.5 0.1 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.1 EWC45038.1 - 0.0015 18.1 0.4 0.0015 18.1 0.3 2.5 3 0 0 3 3 3 1 TPR repeat TPR_2 PF07719.12 EWC45038.1 - 1.7 8.7 5.9 2.8 8.0 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat NAD_binding_6 PF08030.7 EWC45039.1 - 1.5e-33 115.9 0.0 2.6e-33 115.1 0.0 1.4 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.7 EWC45039.1 - 1.1e-22 79.8 0.0 2.4e-21 75.5 0.0 2.5 2 0 0 2 2 2 1 FAD-binding domain Ferric_reduct PF01794.14 EWC45039.1 - 2.5e-15 56.6 10.7 2.5e-15 56.6 7.4 2.2 1 1 1 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_6 PF00970.19 EWC45039.1 - 0.00013 22.0 0.0 0.00028 20.9 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain TFIID_20kDa PF03847.8 EWC45040.1 - 1.2e-27 95.9 0.4 1.2e-27 95.9 0.3 1.6 2 0 0 2 2 2 1 Transcription initiation factor TFIID subunit A Histone PF00125.19 EWC45040.1 - 0.017 15.2 0.0 0.036 14.1 0.0 1.5 1 0 0 1 1 1 0 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 EWC45040.1 - 0.088 12.8 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Spectrin PF00435.16 EWC45040.1 - 0.22 11.8 5.1 4.4 7.6 0.1 3.4 3 0 0 3 3 3 0 Spectrin repeat DUF2434 PF10361.4 EWC45042.1 - 8.8e-80 267.9 7.1 2.7e-79 266.3 4.8 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF2434) DUF4149 PF13664.1 EWC45042.1 - 0.28 11.2 9.2 23 5.1 0.0 3.6 3 1 0 3 3 3 0 Domain of unknown function (DUF4149) 7tm_7 PF08395.7 EWC45042.1 - 2 7.3 16.4 0.3 10.0 7.3 2.3 1 1 0 1 1 1 0 7tm Chemosensory receptor Rpn3_C PF08375.6 EWC45043.1 - 2.4e-25 88.7 4.2 5e-25 87.7 2.9 1.6 1 0 0 1 1 1 1 Proteasome regulatory subunit C-terminal PCI PF01399.22 EWC45043.1 - 2.3e-20 72.8 0.1 1.4e-19 70.3 0.0 2.4 2 0 0 2 2 2 1 PCI domain PCI_Csn8 PF10075.4 EWC45043.1 - 0.0081 15.9 0.3 0.035 13.8 0.2 2.1 1 1 0 1 1 1 1 COP9 signalosome, subunit CSN8 BTV_NS2 PF04514.7 EWC45043.1 - 0.056 12.3 2.6 0.086 11.7 1.8 1.2 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 Vma12 PF11712.3 EWC45044.1 - 4.9e-28 97.6 0.0 6.5e-28 97.2 0.0 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum-based factor for assembly of V-ATPase Claudin_2 PF13903.1 EWC45044.1 - 0.0016 18.1 0.0 0.0022 17.7 0.0 1.2 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction DUF2512 PF10710.4 EWC45044.1 - 0.003 16.9 0.1 0.0046 16.4 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2512) Chordopox_A13L PF05961.6 EWC45044.1 - 0.022 14.6 0.1 0.045 13.6 0.0 1.5 1 0 0 1 1 1 0 Chordopoxvirus A13L protein NicO PF03824.11 EWC45044.1 - 0.026 13.8 0.1 0.037 13.3 0.1 1.3 1 0 0 1 1 1 0 High-affinity nickel-transport protein Lig_chan PF00060.21 EWC45044.1 - 0.028 14.1 0.1 0.071 12.8 0.0 1.6 1 1 0 1 1 1 0 Ligand-gated ion channel DUF3357 PF11837.3 EWC45044.1 - 0.15 11.9 0.3 0.48 10.2 0.1 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF3357) UDPG_MGDP_dh_N PF03721.9 EWC45045.1 - 2.5e-57 193.2 0.0 2.9e-56 189.7 0.0 2.1 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh_C PF03720.10 EWC45045.1 - 4.5e-34 116.7 0.2 2.7e-33 114.3 0.1 2.1 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain UDPG_MGDP_dh PF00984.14 EWC45045.1 - 8.9e-31 105.9 0.0 1.8e-30 105.0 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain NAD_binding_2 PF03446.10 EWC45045.1 - 0.025 14.4 0.1 5.2 6.8 0.0 2.9 2 1 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase Saccharop_dh PF03435.13 EWC45045.1 - 0.056 12.4 0.0 0.088 11.7 0.0 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase XPG_I PF00867.13 EWC45046.1 - 5.2e-24 84.1 0.1 1e-23 83.1 0.0 1.5 1 0 0 1 1 1 1 XPG I-region XPG_I_2 PF12813.2 EWC45046.1 - 6.9e-09 35.5 0.0 1.1e-08 34.8 0.0 1.3 1 0 0 1 1 1 1 XPG domain containing XPG_N PF00752.12 EWC45046.1 - 0.0009 19.4 0.0 0.0022 18.2 0.0 1.6 1 0 0 1 1 1 1 XPG N-terminal domain 5_3_exonuc PF01367.15 EWC45046.1 - 0.0053 16.9 0.0 0.23 11.7 0.0 2.4 2 1 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold SMC_N PF02463.14 EWC45047.1 - 4.3e-22 78.4 15.2 1.2e-21 76.9 10.5 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 EWC45047.1 - 2.5e-12 47.5 0.3 2.5e-12 47.5 0.2 4.8 2 2 2 4 4 4 1 AAA domain AAA_21 PF13304.1 EWC45047.1 - 3.5e-08 33.7 1.6 0.0045 17.0 0.1 2.8 2 1 0 2 2 2 2 AAA domain SbcCD_C PF13558.1 EWC45047.1 - 6e-05 22.8 0.1 0.00038 20.3 0.0 2.3 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.1 EWC45047.1 - 0.0043 16.5 0.1 0.013 14.9 0.1 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain PTCB-BRCT PF12738.2 EWC45048.1 - 1.7e-13 50.1 0.0 3.4e-13 49.2 0.0 1.5 1 0 0 1 1 1 1 twin BRCT domain BRCT PF00533.21 EWC45048.1 - 2.4e-09 37.2 0.0 4.3e-09 36.4 0.0 1.4 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain DUF3006 PF11213.3 EWC45048.1 - 8.8e-05 22.1 0.0 0.00024 20.8 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3006) fn3 PF00041.16 EWC45048.1 - 0.00037 20.5 0.1 0.001 19.1 0.1 1.7 1 0 0 1 1 1 1 Fibronectin type III domain MAM33 PF02330.11 EWC45049.1 - 3.5e-35 121.6 2.1 4.8e-34 117.9 1.4 2.0 1 1 0 1 1 1 1 Mitochondrial glycoprotein AIP3 PF03915.8 EWC45049.1 - 0.071 12.0 1.1 0.098 11.5 0.8 1.2 1 0 0 1 1 1 0 Actin interacting protein 3 Cys_Met_Meta_PP PF01053.15 EWC45050.1 - 2e-28 98.7 0.0 2.7e-28 98.3 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.16 EWC45050.1 - 0.0008 18.4 0.0 0.0013 17.7 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Nrap PF03813.9 EWC45051.1 - 9.8e-132 440.4 0.0 1.4e-131 439.9 0.0 1.1 1 0 0 1 1 1 1 Nrap protein YccV-like PF08755.6 EWC45053.1 - 5.8e-16 58.2 0.0 6.9e-16 58.0 0.0 1.1 1 0 0 1 1 1 1 Hemimethylated DNA-binding protein YccV like Pkinase PF00069.20 EWC45054.1 - 8.2e-58 195.5 0.0 1.5e-57 194.6 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC45054.1 - 4.2e-34 117.7 0.0 1.6e-31 109.3 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 EWC45054.1 - 1.4e-07 30.7 0.0 4.1e-07 29.2 0.0 1.7 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 EWC45054.1 - 0.0064 16.2 0.1 0.014 15.1 0.1 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family PIG-X PF08320.7 EWC45055.1 - 3.3e-55 186.5 0.0 4.5e-55 186.1 0.0 1.2 1 0 0 1 1 1 1 PIG-X / PBN1 PyocinActivator PF11112.3 EWC45055.1 - 0.069 12.9 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 Pyocin activator protein PrtN Rubis-subs-bind PF09273.6 EWC45056.1 - 2.7e-07 30.5 0.1 5e-07 29.6 0.0 1.4 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding SET PF00856.23 EWC45056.1 - 0.00041 20.6 0.0 0.00089 19.5 0.0 1.5 1 0 0 1 1 1 1 SET domain P5-ATPase PF12409.3 EWC45057.1 - 8.3e-38 128.9 0.0 2.1e-37 127.5 0.0 1.8 1 0 0 1 1 1 1 P5-type ATPase cation transporter HAD PF12710.2 EWC45057.1 - 2.6e-31 109.2 0.0 1.2e-30 107.1 0.0 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.15 EWC45057.1 - 8e-26 90.4 0.0 2e-25 89.1 0.0 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.21 EWC45057.1 - 3.6e-19 70.0 0.0 2.9e-06 27.8 0.0 3.2 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 EWC45057.1 - 9.7e-05 21.7 0.0 0.00024 20.4 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_like2 PF13246.1 EWC45057.1 - 0.0028 17.5 0.0 0.0082 16.0 0.0 1.7 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 EWC45057.1 - 0.015 14.9 0.0 0.24 10.9 0.0 2.1 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Radical_SAM PF04055.16 EWC45058.1 - 1.6e-17 64.2 0.1 3.8e-17 62.9 0.0 1.6 1 0 0 1 1 1 1 Radical SAM superfamily Acetyltransf_1 PF00583.19 EWC45058.1 - 4.5e-12 45.8 0.0 1.6e-11 44.0 0.0 2.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family RRM_1 PF00076.17 EWC45059.1 - 4e-09 35.9 0.0 7.8e-09 35.0 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EWC45059.1 - 8.3e-07 28.7 0.0 1.7e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EWC45059.1 - 1.7e-05 24.7 0.0 3.1e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 EWC45059.1 - 0.00068 19.3 0.0 0.0014 18.3 0.0 1.5 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif zf-CCCH PF00642.19 EWC45059.1 - 0.023 14.3 3.6 0.047 13.3 2.5 1.5 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Carla_C4 PF01623.12 EWC45059.1 - 0.77 9.5 3.6 0.58 9.9 0.8 2.0 3 0 0 3 3 3 0 Carlavirus putative nucleic acid binding protein tRNA-synt_2b PF00587.20 EWC45060.1 - 3.9e-35 120.9 0.1 7.4e-35 120.0 0.0 1.5 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.17 EWC45060.1 - 8.3e-16 57.9 2.1 8.3e-16 57.9 1.4 1.9 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain BAR PF03114.13 EWC45061.1 - 2.5e-60 203.8 3.4 3e-60 203.5 2.3 1.1 1 0 0 1 1 1 1 BAR domain AMPKBI PF04739.10 EWC45062.1 - 6.4e-30 102.9 1.1 3.8e-29 100.5 0.1 2.2 1 1 1 2 2 2 1 5'-AMP-activated protein kinase beta subunit, interation domain FA_desaturase PF00487.19 EWC45063.1 - 0.24 10.8 3.6 0.42 10.0 2.5 1.4 1 0 0 1 1 1 0 Fatty acid desaturase RseC_MucC PF04246.7 EWC45063.1 - 8.1 6.0 8.9 0.5 9.9 1.5 2.0 1 1 1 2 2 2 0 Positive regulator of sigma(E), RseC/MucC TB2_DP1_HVA22 PF03134.14 EWC45064.1 - 2.1e-28 97.8 3.8 2.9e-28 97.4 2.6 1.2 1 0 0 1 1 1 1 TB2/DP1, HVA22 family DUF2583 PF10762.4 EWC45064.1 - 2.5 8.2 4.8 1.8 8.7 1.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2583) DUF1649 PF07855.7 EWC45065.1 - 3.4e-28 98.3 0.8 3.9e-28 98.1 0.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1649) Peroxin-3 PF04882.7 EWC45066.1 - 5.5e-134 447.1 0.0 6.3e-134 446.9 0.0 1.0 1 0 0 1 1 1 1 Peroxin-3 DKCLD PF08068.7 EWC45067.1 - 5.6e-29 99.8 0.1 3.9e-28 97.1 0.1 2.3 2 0 0 2 2 2 1 DKCLD (NUC011) domain PUA PF01472.15 EWC45067.1 - 2.8e-22 78.2 1.8 5.7e-22 77.2 1.3 1.6 1 0 0 1 1 1 1 PUA domain TruB_N PF01509.13 EWC45067.1 - 6.4e-11 42.6 6.5 1.1e-05 25.5 0.0 3.9 2 1 1 3 3 3 2 TruB family pseudouridylate synthase (N terminal domain) DER1 PF04511.10 EWC45068.1 - 8.9e-28 97.1 5.1 1e-27 96.9 3.5 1.0 1 0 0 1 1 1 1 Der1-like family Rhomboid PF01694.17 EWC45068.1 - 0.018 15.0 9.4 0.11 12.5 6.5 2.2 1 1 0 1 1 1 0 Rhomboid family Saccharop_dh PF03435.13 EWC45069.1 - 4.4e-127 424.2 0.0 5.1e-127 424.0 0.0 1.0 1 0 0 1 1 1 1 Saccharopine dehydrogenase Shikimate_DH PF01488.15 EWC45069.1 - 8.3e-06 25.9 0.2 1.4e-05 25.2 0.2 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_10 PF13460.1 EWC45069.1 - 5.5e-05 23.2 1.3 8.4e-05 22.6 0.9 1.3 1 0 0 1 1 1 1 NADH(P)-binding GFO_IDH_MocA PF01408.17 EWC45069.1 - 0.056 13.9 0.3 0.2 12.1 0.3 1.8 2 0 0 2 2 2 0 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_7 PF13241.1 EWC45069.1 - 0.072 13.3 0.3 0.13 12.5 0.2 1.3 1 0 0 1 1 1 0 Putative NAD(P)-binding Kin17_mid PF10357.4 EWC45070.1 - 2.2e-51 172.7 0.8 3.5e-51 172.1 0.6 1.3 1 0 0 1 1 1 1 Domain of Kin17 curved DNA-binding protein zf-C2H2_jaz PF12171.3 EWC45070.1 - 0.00026 21.0 1.6 0.00055 19.9 1.1 1.6 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 EWC45070.1 - 0.00046 20.2 2.5 0.0009 19.3 1.8 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.2 EWC45070.1 - 0.02 14.9 0.3 0.02 14.9 0.2 2.2 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) GWT1 PF06423.7 EWC45071.1 - 1.3 9.0 8.1 0.38 10.8 1.8 2.2 1 1 1 2 2 2 0 GWT1 RFX_DNA_binding PF02257.10 EWC45073.1 - 1.3e-29 102.1 0.1 2.5e-29 101.2 0.1 1.5 1 0 0 1 1 1 1 RFX DNA-binding domain DUF3366 PF11846.3 EWC45073.1 - 0.046 13.5 0.0 0.1 12.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3366) HTH_Tnp_Tc5 PF03221.11 EWC45073.1 - 0.14 12.0 0.0 0.39 10.5 0.0 1.7 1 0 0 1 1 1 0 Tc5 transposase DNA-binding domain zf-TRAF PF02176.13 EWC45073.1 - 0.18 12.2 0.1 0.41 11.0 0.0 1.6 1 0 0 1 1 1 0 TRAF-type zinc finger CTDII PF01556.13 EWC45074.1 - 5.5e-19 67.8 0.3 1.4e-17 63.3 0.0 2.6 2 0 0 2 2 2 1 DnaJ C terminal domain DUF1777 PF08648.7 EWC45074.1 - 1.2e-06 28.4 38.0 2.2e-06 27.5 26.4 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1777) DnaJ PF00226.26 EWC45074.1 - 0.011 15.5 0.0 0.024 14.3 0.0 1.6 1 0 0 1 1 1 0 DnaJ domain MIP-T3 PF10243.4 EWC45074.1 - 0.17 10.3 18.7 0.27 9.6 13.0 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 DUF3827 PF12877.2 EWC45074.1 - 8.2 4.3 10.1 12 3.8 7.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) UreF PF01730.11 EWC45075.1 - 2.3e-11 43.9 1.2 2.6e-11 43.8 0.0 1.7 2 0 0 2 2 2 1 UreF RRM_2 PF04059.7 EWC45076.1 - 1.1e-16 60.6 0.2 1.1e-13 50.9 0.2 2.5 1 1 0 1 1 1 1 RNA recognition motif 2 RRM_1 PF00076.17 EWC45076.1 - 5.6e-06 25.9 0.0 0.026 14.1 0.0 2.9 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EWC45076.1 - 8.9e-06 25.5 0.1 0.2 11.6 0.0 3.3 3 0 0 3 3 3 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EWC45076.1 - 0.00027 20.7 0.2 0.26 11.1 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Peptidase_C3 PF00548.15 EWC45076.1 - 0.41 10.4 1.2 6.5 6.5 0.1 2.2 1 1 1 2 2 2 0 3C cysteine protease (picornain 3C) Sec15 PF04091.7 EWC45077.1 - 1.3e-100 336.8 1.1 1.3e-100 336.8 0.8 2.7 3 0 0 3 3 3 1 Exocyst complex subunit Sec15-like AcetDehyd-dimer PF09290.6 EWC45077.1 - 0.0079 16.1 0.6 0.35 10.7 0.0 2.5 2 0 0 2 2 2 1 Prokaryotic acetaldehyde dehydrogenase, dimerisation HsbA PF12296.3 EWC45077.1 - 0.011 15.5 1.2 0.029 14.2 0.8 1.7 1 0 0 1 1 1 0 Hydrophobic surface binding protein A COG2 PF06148.6 EWC45077.1 - 0.052 13.4 6.8 0.27 11.1 3.2 2.8 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Phage_Gp111 PF07410.6 EWC45077.1 - 0.061 13.4 0.1 0.24 11.5 0.0 1.9 1 1 0 1 1 1 0 Streptococcus thermophilus bacteriophage Gp111 protein CBFD_NFYB_HMF PF00808.18 EWC45078.1 - 2.1e-19 69.3 0.7 2.9e-19 68.8 0.5 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 EWC45078.1 - 7.9e-12 45.1 0.1 1.1e-11 44.6 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-X PF09415.5 EWC45078.1 - 0.013 15.2 0.0 0.02 14.7 0.0 1.2 1 0 0 1 1 1 0 CENP-S associating Centromere protein X DUF2360 PF10152.4 EWC45078.1 - 4.4 7.5 11.5 0.32 11.2 1.3 2.3 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein (DUF2360) Fcf2 PF08698.6 EWC45079.1 - 3e-31 107.3 0.1 3e-31 107.3 0.1 1.7 2 0 0 2 2 2 1 Fcf2 pre-rRNA processing Seryl_tRNA_N PF02403.17 EWC45079.1 - 0.0062 16.5 1.3 0.0062 16.5 0.9 1.8 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain TPX2 PF06886.6 EWC45079.1 - 4.9 7.2 7.3 1.5 8.9 2.3 2.3 2 1 0 2 2 2 0 Targeting protein for Xklp2 (TPX2) D123 PF07065.9 EWC45080.1 - 5.1e-91 304.8 0.0 7.3e-91 304.3 0.0 1.2 1 0 0 1 1 1 1 D123 RAI1 PF08652.6 EWC45081.1 - 5e-27 93.4 0.0 8.8e-27 92.6 0.0 1.4 1 0 0 1 1 1 1 RAI1 like PD-(D/E)XK nuclease Zip PF02535.17 EWC45082.1 - 0.71 8.8 8.4 1.2 8.0 5.8 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter SelP_N PF04592.9 EWC45082.1 - 0.87 8.9 9.2 1.5 8.1 6.4 1.5 1 0 0 1 1 1 0 Selenoprotein P, N terminal region BAF1_ABF1 PF04684.8 EWC45082.1 - 6.9 5.4 10.7 9.1 4.9 7.4 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF410 PF04190.8 EWC45083.1 - 1.5e-51 175.4 0.0 1.8e-51 175.1 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF410) SNAP PF14938.1 EWC45083.1 - 0.18 10.9 0.1 6 5.9 0.0 2.4 3 0 0 3 3 3 0 Soluble NSF attachment protein, SNAP MBOAT PF03062.14 EWC45084.1 - 5.1e-50 170.4 10.1 8.5e-50 169.6 7.0 1.3 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family tRNA-synt_1b PF00579.20 EWC45085.1 - 2.7e-67 226.9 0.0 4.6e-67 226.1 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) Ribosomal_S10 PF00338.17 EWC45085.1 - 4.7e-23 80.8 0.0 1.3e-22 79.3 0.0 1.9 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e Fib_alpha PF08702.5 EWC45085.1 - 0.78 9.8 2.8 0.88 9.6 0.4 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family EPL1 PF10513.4 EWC45088.1 - 2.4e-29 102.6 0.5 2.4e-29 102.6 0.4 2.2 2 1 0 2 2 2 1 Enhancer of polycomb-like PNP_UDP_1 PF01048.15 EWC45089.1 - 9.9e-50 168.6 0.1 1.2e-49 168.4 0.1 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily Peptidase_M22 PF00814.20 EWC45090.1 - 4.6e-84 282.0 0.0 5.4e-84 281.8 0.0 1.0 1 0 0 1 1 1 1 Glycoprotease family NIF PF03031.13 EWC45091.1 - 1.6e-14 53.8 0.0 2.5e-14 53.2 0.0 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase DUF947 PF06102.7 EWC45092.1 - 5.8e-49 166.1 27.5 5.8e-49 166.1 19.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF947) Ribosomal_S9 PF00380.14 EWC45094.1 - 2e-34 118.4 0.0 2.1e-33 115.1 0.0 2.0 2 0 0 2 2 2 1 Ribosomal protein S9/S16 EF1G PF00647.14 EWC45095.1 - 4.6e-46 154.9 0.1 9.1e-46 153.9 0.0 1.5 1 0 0 1 1 1 1 Elongation factor 1 gamma, conserved domain GST_C PF00043.20 EWC45095.1 - 2e-10 40.5 0.5 6e-10 38.9 0.0 2.1 3 1 0 3 3 3 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.15 EWC45095.1 - 3e-10 40.1 0.0 7.2e-10 38.8 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.1 EWC45095.1 - 1.7e-07 31.3 0.0 3.3e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 EWC45095.1 - 3.7e-07 29.9 0.1 1.2e-06 28.2 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 EWC45095.1 - 0.00098 19.5 0.0 0.0023 18.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.1 EWC45095.1 - 0.025 14.5 0.0 0.06 13.3 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Endonuc-FokI_C PF09254.6 EWC45095.1 - 0.12 11.4 5.9 0.62 9.1 0.2 2.3 2 0 0 2 2 2 0 Restriction endonuclease FokI, C terminal Ribosomal_60s PF00428.14 EWC45095.1 - 2.7 8.4 12.0 14 6.2 8.6 1.8 2 0 0 2 2 2 0 60s Acidic ribosomal protein EF-hand_1 PF00036.27 EWC45096.1 - 2e-25 86.1 13.8 1.2e-06 27.3 0.6 4.4 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 EWC45096.1 - 2.4e-22 78.8 3.6 4.3e-12 46.0 0.6 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 EWC45096.1 - 5e-20 69.5 6.5 4.2e-05 23.0 0.0 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.1 EWC45096.1 - 1.7e-16 58.7 13.5 3.6e-05 22.9 0.2 4.4 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.1 EWC45096.1 - 6.5e-15 54.4 16.5 4e-05 23.1 0.8 4.8 2 2 2 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.4 EWC45096.1 - 1.4e-06 28.3 0.0 0.00086 19.3 0.0 2.2 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 EWC45096.1 - 5.8e-05 22.7 8.6 0.014 15.1 0.4 3.9 1 1 3 4 4 4 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.1 EWC45096.1 - 0.0053 16.6 0.1 0.48 10.3 0.1 3.0 2 1 1 3 3 3 1 EF-hand domain HA2 PF04408.18 EWC45097.1 - 1.7e-18 66.5 0.0 4.6e-18 65.1 0.0 1.8 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.26 EWC45097.1 - 2.8e-11 43.1 0.0 2.1e-10 40.3 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.11 EWC45097.1 - 3.1e-11 43.0 0.0 1.2e-10 41.2 0.0 2.0 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.24 EWC45097.1 - 1.6e-08 34.2 0.4 1.6e-07 30.9 0.1 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.1 EWC45097.1 - 6.5e-05 23.0 0.0 0.00035 20.7 0.0 2.3 1 0 0 1 1 1 1 AAA domain KaiC PF06745.8 EWC45097.1 - 0.04 13.0 0.0 0.1 11.7 0.0 1.7 1 0 0 1 1 1 0 KaiC AAA_29 PF13555.1 EWC45097.1 - 0.081 12.4 0.0 0.2 11.2 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain ResIII PF04851.10 EWC45097.1 - 0.39 10.5 4.4 1.3 8.8 0.0 3.3 4 0 0 4 4 4 0 Type III restriction enzyme, res subunit AAA_23 PF13476.1 EWC45097.1 - 0.55 10.5 12.0 0.31 11.3 0.1 2.8 2 1 0 2 2 2 0 AAA domain CDC45 PF02724.9 EWC45097.1 - 2.6 5.9 10.5 6.6 4.6 7.0 1.8 2 0 0 2 2 2 0 CDC45-like protein EB1_binding PF05937.6 EWC45098.1 - 0.071 13.4 0.2 0.071 13.4 0.1 2.5 3 0 0 3 3 3 0 EB-1 Binding Domain RPEL PF02755.10 EWC45098.1 - 0.098 12.0 0.0 0.2 11.0 0.0 1.6 1 0 0 1 1 1 0 RPEL repeat Pet127 PF08634.5 EWC45099.1 - 2.7e-88 295.7 3.0 3.8e-67 226.3 0.1 2.3 1 1 1 2 2 2 2 Mitochondrial protein Pet127 LRR_6 PF13516.1 EWC45100.1 - 0.2 11.8 9.5 50 4.4 0.0 7.0 8 0 0 8 8 8 0 Leucine Rich repeat DUF2015 PF09435.5 EWC45101.1 - 1e-37 128.8 0.0 1.1e-37 128.6 0.0 1.0 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF2015) PINIT PF14324.1 EWC45103.1 - 1.7e-30 105.9 0.1 2.7e-30 105.3 0.1 1.3 1 0 0 1 1 1 1 PINIT domain zf-MIZ PF02891.15 EWC45103.1 - 4.4e-20 70.9 8.7 7.2e-20 70.2 6.0 1.4 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.3 EWC45103.1 - 1.8e-05 24.1 4.2 4.1e-05 23.0 2.9 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit SAP PF02037.22 EWC45103.1 - 0.054 13.0 0.5 0.12 11.8 0.3 1.7 1 0 0 1 1 1 0 SAP domain zf-Sec23_Sec24 PF04810.10 EWC45103.1 - 0.061 12.9 0.2 0.13 11.8 0.1 1.5 1 0 0 1 1 1 0 Sec23/Sec24 zinc finger Abi PF02517.11 EWC45104.1 - 9.6e-14 51.2 9.1 9.6e-14 51.2 6.3 1.8 2 0 0 2 2 2 1 CAAX protease self-immunity TRAPP PF04051.11 EWC45105.1 - 1.3e-10 40.9 0.0 1.4e-10 40.8 0.0 1.0 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component DUF2378 PF09536.5 EWC45105.1 - 0.029 13.8 0.0 0.031 13.7 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2378) Ldh_1_N PF00056.18 EWC45106.1 - 1.1e-42 145.2 0.0 1.5e-42 144.7 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.13 EWC45106.1 - 5.1e-38 130.5 0.0 6.6e-38 130.1 0.0 1.1 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain 3Beta_HSD PF01073.14 EWC45106.1 - 0.021 13.5 0.0 0.029 13.0 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Semialdhyde_dh PF01118.19 EWC45106.1 - 0.041 14.2 0.1 0.34 11.2 0.0 2.3 3 0 0 3 3 3 0 Semialdehyde dehydrogenase, NAD binding domain THF_DHG_CYH_C PF02882.14 EWC45106.1 - 0.07 12.1 0.7 4.8 6.2 0.0 2.9 1 1 1 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Glyco_hydro_4 PF02056.11 EWC45106.1 - 0.073 12.3 0.0 0.24 10.6 0.0 1.8 1 1 1 2 2 2 0 Family 4 glycosyl hydrolase Rep_fac_C PF08542.6 EWC45107.1 - 3.8e-21 74.8 0.1 1.1e-20 73.3 0.0 1.8 2 0 0 2 2 2 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.1 EWC45107.1 - 4.3e-12 45.9 0.0 5.4e-10 39.1 0.0 2.3 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.24 EWC45107.1 - 1e-11 45.1 0.0 1.9e-11 44.2 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.1 EWC45107.1 - 3.4e-07 30.1 0.0 9.6e-07 28.7 0.0 1.8 1 1 1 2 2 2 1 AAA domain RuvB_N PF05496.7 EWC45107.1 - 1.4e-06 27.5 0.0 5.3e-06 25.6 0.0 1.8 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus Viral_helicase1 PF01443.13 EWC45107.1 - 1e-05 25.1 0.0 1.8e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.1 EWC45107.1 - 3e-05 24.1 0.2 0.061 13.4 0.1 3.0 2 1 1 3 3 3 2 AAA domain Rad17 PF03215.10 EWC45107.1 - 3.2e-05 22.8 0.0 0.02 13.6 0.0 2.3 2 0 0 2 2 2 2 Rad17 cell cycle checkpoint protein AAA_16 PF13191.1 EWC45107.1 - 6.5e-05 22.9 0.2 0.0017 18.3 0.0 2.6 1 1 2 3 3 3 1 AAA ATPase domain AAA_3 PF07726.6 EWC45107.1 - 0.00013 21.5 0.0 0.00023 20.7 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta PF06144.8 EWC45107.1 - 0.00037 20.0 0.0 0.0006 19.3 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_19 PF13245.1 EWC45107.1 - 0.0013 18.4 0.0 0.0034 17.1 0.0 1.8 1 0 0 1 1 1 1 Part of AAA domain AAA_10 PF12846.2 EWC45107.1 - 0.0021 17.5 0.1 0.36 10.2 0.0 2.5 1 1 1 2 2 2 1 AAA-like domain NTPase_1 PF03266.10 EWC45107.1 - 0.0033 17.1 0.4 0.028 14.1 0.1 2.4 2 1 1 3 3 3 1 NTPase AAA_25 PF13481.1 EWC45107.1 - 0.0039 16.6 0.1 0.1 11.9 0.0 2.3 1 1 0 2 2 2 1 AAA domain ArgK PF03308.11 EWC45107.1 - 0.0085 14.8 0.1 0.02 13.6 0.1 1.6 1 1 0 1 1 1 1 ArgK protein Mg_chelatase PF01078.16 EWC45107.1 - 0.012 14.8 0.0 0.12 11.4 0.0 2.1 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_11 PF13086.1 EWC45107.1 - 0.012 15.1 0.0 0.016 14.7 0.0 1.4 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.1 EWC45107.1 - 0.032 14.5 0.0 0.065 13.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.13 EWC45107.1 - 0.041 13.3 0.1 0.08 12.4 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family KTI12 PF08433.5 EWC45107.1 - 0.043 13.0 0.0 0.078 12.1 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 DEAD PF00270.24 EWC45107.1 - 0.049 13.1 0.1 1 8.8 0.0 2.4 1 1 1 2 2 2 0 DEAD/DEAH box helicase Asp PF00026.18 EWC45108.1 - 4.8e-65 219.8 1.4 6.1e-65 219.5 1.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.1 EWC45108.1 - 1.8e-08 34.7 2.3 0.00086 19.7 0.0 3.8 3 1 0 3 3 3 2 Aspartyl protease TAXi_N PF14543.1 EWC45108.1 - 8.5e-08 32.3 0.0 1e-06 28.7 0.0 2.6 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal gag-asp_proteas PF13975.1 EWC45108.1 - 1.5e-05 24.7 0.0 8.7e-05 22.2 0.0 2.2 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease TAXi_C PF14541.1 EWC45108.1 - 0.00079 19.0 0.1 0.021 14.4 0.1 2.3 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal RVP PF00077.15 EWC45108.1 - 0.03 14.2 0.1 0.19 11.6 0.0 2.3 2 0 0 2 2 2 0 Retroviral aspartyl protease Ribosomal_L28e PF01778.12 EWC45109.1 - 6.9e-31 107.0 0.4 9.9e-31 106.5 0.3 1.2 1 0 0 1 1 1 1 Ribosomal L28e protein family zf-Tim10_DDP PF02953.10 EWC45111.1 - 4.2e-16 57.9 6.6 6.5e-16 57.3 0.9 2.2 2 0 0 2 2 2 2 Tim10/DDP family zinc finger DUF842 PF05811.8 EWC45111.1 - 0.09 12.2 2.9 0.053 12.9 0.5 1.8 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF842) Gly_transf_sug PF04488.10 EWC45112.1 - 1.1e-17 64.3 0.0 2.1e-17 63.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif TcdA_TcdB PF12919.2 EWC45112.1 - 0.00018 20.1 0.8 0.041 12.3 0.1 2.1 2 0 0 2 2 2 2 TcdA/TcdB catalytic glycosyltransferase domain DUF3649 PF12365.3 EWC45112.1 - 6.7 6.3 6.2 1.3 8.5 1.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3649) cwf21 PF08312.7 EWC45113.1 - 3e-18 65.3 6.3 5.3e-18 64.6 4.4 1.4 1 0 0 1 1 1 1 cwf21 domain VIT1 PF01988.14 EWC45113.1 - 0.2 11.0 0.6 0.25 10.7 0.4 1.1 1 0 0 1 1 1 0 VIT family Bd3614_N PF14442.1 EWC45114.1 - 0.015 15.2 0.9 0.015 15.2 0.6 2.0 2 0 0 2 2 2 0 Bd3614-like deaminase N-terminal DUF4477 PF14780.1 EWC45114.1 - 0.077 12.3 5.2 0.096 12.0 1.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4477) Actin PF00022.14 EWC45115.1 - 1.5e-150 501.0 0.0 4.7e-150 499.3 0.0 1.7 1 1 0 1 1 1 1 Actin ESSS PF10183.4 EWC45115.1 - 0.041 14.2 0.0 0.12 12.8 0.0 1.8 1 1 1 2 2 2 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) IGPD PF00475.13 EWC45116.1 - 1.2e-58 197.0 0.3 3.2e-58 195.7 0.1 1.6 2 0 0 2 2 2 1 Imidazoleglycerol-phosphate dehydratase GARS_A PF01071.14 EWC45117.1 - 1.2e-82 276.1 0.1 2.3e-82 275.2 0.0 1.5 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain GARS_N PF02844.10 EWC45117.1 - 1.4e-35 121.7 0.1 5.1e-35 119.9 0.1 2.1 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, N domain AIRS_C PF02769.17 EWC45117.1 - 1.2e-27 96.8 0.0 3.7e-27 95.2 0.0 1.8 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain GARS_C PF02843.11 EWC45117.1 - 7.8e-25 86.8 0.1 1.9e-24 85.6 0.0 1.7 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, C domain AIRS PF00586.19 EWC45117.1 - 8.9e-18 64.3 1.2 2.8e-17 62.7 0.8 1.9 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain ATP-grasp_4 PF13535.1 EWC45117.1 - 9.6e-11 41.7 0.1 4.8e-10 39.4 0.0 2.1 2 1 0 2 2 2 1 ATP-grasp domain ATPgrasp_Ter PF15632.1 EWC45117.1 - 1.3e-08 33.9 0.0 2.8e-08 32.8 0.0 1.5 2 0 0 2 2 2 1 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp PF02222.17 EWC45117.1 - 0.00018 20.8 0.0 0.00033 20.0 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.9 EWC45117.1 - 0.00037 20.3 0.1 0.0017 18.2 0.0 2.2 2 1 0 2 2 2 1 ATP-grasp domain ATP-grasp_2 PF08442.5 EWC45117.1 - 0.014 14.8 0.0 0.025 13.9 0.0 1.3 1 0 0 1 1 1 0 ATP-grasp domain CPSase_L_D2 PF02786.12 EWC45117.1 - 0.054 12.7 0.0 0.089 12.0 0.0 1.3 1 0 0 1 1 1 0 Carbamoyl-phosphate synthase L chain, ATP binding domain ATPgrasp_ST PF14397.1 EWC45117.1 - 0.17 10.9 0.0 0.31 10.0 0.0 1.3 1 0 0 1 1 1 0 Sugar-transfer associated ATP-grasp SMI1_KNR4 PF09346.5 EWC45118.1 - 1.5e-32 112.3 0.0 2.2e-32 111.8 0.0 1.3 1 0 0 1 1 1 1 SMI1 / KNR4 family (SUKH-1) TPT PF03151.11 EWC45119.1 - 1.5e-11 44.2 9.1 1.5e-11 44.2 6.3 2.7 1 1 2 3 3 3 1 Triose-phosphate Transporter family UAA PF08449.6 EWC45119.1 - 5.7e-10 38.5 23.3 7.3e-10 38.2 16.2 1.1 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.15 EWC45119.1 - 0.00046 20.2 6.8 0.00046 20.2 4.7 2.4 2 0 0 2 2 2 2 EamA-like transporter family Tad PF13400.1 EWC45119.1 - 0.24 11.4 2.0 2.3 8.3 0.5 3.0 3 0 0 3 3 3 0 Putative Flp pilus-assembly TadE/G-like Cwf_Cwc_15 PF04889.7 EWC45120.1 - 1.5 8.5 6.5 1.5 8.4 4.5 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein PDT PF00800.13 EWC45121.1 - 3.1e-64 215.8 0.0 3.9e-64 215.5 0.0 1.1 1 0 0 1 1 1 1 Prephenate dehydratase ACT PF01842.20 EWC45121.1 - 1.4e-06 27.6 0.0 3.4e-06 26.4 0.0 1.7 1 0 0 1 1 1 1 ACT domain eRF1_2 PF03464.10 EWC45122.1 - 3.1e-47 160.2 0.2 5.3e-47 159.4 0.1 1.4 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.10 EWC45122.1 - 3.8e-39 133.4 0.2 9.2e-39 132.2 0.1 1.7 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.10 EWC45122.1 - 6.9e-28 96.8 0.0 1.3e-27 95.9 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 1 DUF3572 PF12096.3 EWC45123.1 - 0.078 12.8 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3572) DUF2346 PF09803.4 EWC45124.1 - 6.5e-07 29.1 2.1 1.1e-06 28.4 1.5 1.4 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2346) CR6_interact PF10147.4 EWC45124.1 - 0.004 16.5 0.6 0.0048 16.2 0.4 1.1 1 0 0 1 1 1 1 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 Ras PF00071.17 EWC45125.1 - 6.3e-49 165.4 0.0 7.4e-49 165.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EWC45125.1 - 2.4e-13 50.6 0.0 3.6e-13 50.0 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EWC45125.1 - 4.9e-10 38.9 0.0 7.2e-10 38.3 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 EWC45125.1 - 1.3e-05 24.4 0.0 1.6e-05 24.2 0.0 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.5 EWC45125.1 - 2.1e-05 23.8 0.1 3.4e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_16 PF13191.1 EWC45125.1 - 2.3e-05 24.4 0.1 5.4e-05 23.2 0.0 1.5 2 0 0 2 2 2 1 AAA ATPase domain MMR_HSR1 PF01926.18 EWC45125.1 - 4e-05 23.5 0.1 8.8e-05 22.4 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 EWC45125.1 - 0.001 18.5 0.0 0.0091 15.4 0.0 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.1 EWC45125.1 - 0.0029 17.7 0.0 0.0057 16.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain PduV-EutP PF10662.4 EWC45125.1 - 0.0036 16.7 0.0 0.067 12.6 0.0 2.3 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation ATP_bind_1 PF03029.12 EWC45125.1 - 0.0061 16.1 0.0 0.92 9.0 0.0 2.3 1 1 1 2 2 2 2 Conserved hypothetical ATP binding protein ADH_zinc_N PF00107.21 EWC45125.1 - 0.0092 15.5 0.0 0.021 14.3 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AAA_14 PF13173.1 EWC45125.1 - 0.018 14.9 0.0 0.022 14.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain Arch_ATPase PF01637.13 EWC45125.1 - 0.03 14.0 0.0 0.041 13.5 0.0 1.5 1 1 0 1 1 1 0 Archaeal ATPase AAA_24 PF13479.1 EWC45125.1 - 0.08 12.5 0.1 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain Abhydrolase_6 PF12697.2 EWC45126.1 - 3.6e-25 89.1 0.2 8.8e-14 51.9 0.0 2.1 2 0 0 2 2 2 2 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EWC45126.1 - 2.2e-10 40.4 0.0 7.5e-05 22.3 0.0 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EWC45126.1 - 1.2e-07 31.6 0.0 3.6e-07 30.0 0.0 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 EWC45126.1 - 0.012 15.4 0.0 0.022 14.6 0.0 1.4 1 0 0 1 1 1 0 Putative lysophospholipase PGAP1 PF07819.8 EWC45126.1 - 0.051 13.1 0.0 0.081 12.4 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein RNA_pol_L_2 PF13656.1 EWC45127.1 - 7.3e-32 108.6 0.0 9.6e-32 108.2 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.19 EWC45127.1 - 2.7e-14 52.0 0.0 3.5e-14 51.6 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Yqai PF09466.5 EWC45127.1 - 0.071 13.1 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Hypothetical protein Yqai Osteopontin PF00865.13 EWC45127.1 - 3.6 6.7 7.5 4.5 6.4 5.2 1.1 1 0 0 1 1 1 0 Osteopontin Vps51 PF08700.6 EWC45128.1 - 2.4e-11 43.3 0.3 1.3e-10 40.9 0.1 2.3 2 0 0 2 2 2 1 Vps51/Vps67 COG2 PF06148.6 EWC45128.1 - 0.18 11.6 2.5 0.26 11.1 0.5 2.2 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 COG5 PF10392.4 EWC45128.1 - 0.2 11.6 4.7 0.13 12.1 0.2 2.9 3 0 0 3 3 3 0 Golgi transport complex subunit 5 Tyr-DNA_phospho PF06087.7 EWC45129.1 - 1.1e-61 208.7 0.0 2.2e-61 207.8 0.0 1.4 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase PLDc_2 PF13091.1 EWC45129.1 - 0.00023 20.9 0.0 0.0013 18.4 0.0 2.3 2 0 0 2 2 2 1 PLD-like domain Gti1_Pac2 PF09729.4 EWC45130.1 - 5.3e-51 172.8 0.0 8.7e-51 172.1 0.0 1.3 1 0 0 1 1 1 1 Gti1/Pac2 family GIDA PF01134.17 EWC45131.1 - 2.6e-154 513.8 0.0 3.2e-154 513.5 0.0 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A GIDA_assoc_3 PF13932.1 EWC45131.1 - 1.2e-17 63.6 0.0 3.2e-17 62.3 0.0 1.6 1 0 0 1 1 1 1 GidA associated domain 3 Pyr_redox_2 PF07992.9 EWC45131.1 - 5.8e-08 32.8 0.2 1.6e-07 31.4 0.2 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 EWC45131.1 - 1.8e-07 30.6 0.1 2.9e-07 29.9 0.1 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 EWC45131.1 - 2.2e-05 23.4 3.5 5.3e-05 22.2 2.4 1.7 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.19 EWC45131.1 - 0.00017 20.6 1.3 0.22 10.3 1.3 2.4 2 0 0 2 2 2 2 FAD dependent oxidoreductase Thi4 PF01946.12 EWC45131.1 - 0.0014 17.8 0.4 0.0025 16.9 0.3 1.4 1 0 0 1 1 1 1 Thi4 family Pyr_redox PF00070.22 EWC45131.1 - 0.0094 16.3 0.4 0.024 15.0 0.3 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 EWC45131.1 - 0.04 12.3 6.0 0.11 10.8 0.8 2.5 3 0 0 3 3 3 0 HI0933-like protein DUF1640 PF07798.6 EWC45132.1 - 1e-11 45.1 3.6 1.3e-11 44.8 2.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) Asp PF00026.18 EWC45133.1 - 7.1e-110 367.1 0.7 9.9e-110 366.6 0.3 1.4 2 0 0 2 2 2 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 EWC45133.1 - 1.9e-10 40.9 0.1 6.8e-10 39.1 0.0 2.0 2 0 0 2 2 2 1 Xylanase inhibitor N-terminal TAXi_C PF14541.1 EWC45133.1 - 5.8e-07 29.2 0.0 8.9e-06 25.3 0.0 2.4 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.1 EWC45133.1 - 4.3e-06 27.1 0.1 0.06 13.8 0.0 2.7 2 0 0 2 2 2 2 Aspartyl protease Pkinase PF00069.20 EWC45134.1 - 1.1e-66 224.6 0.0 1.7e-66 224.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC45134.1 - 2e-46 158.1 0.0 3.2e-46 157.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EWC45134.1 - 1.1e-08 34.4 0.0 8.1e-07 28.2 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.9 EWC45134.1 - 0.033 13.2 0.0 0.073 12.1 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Yippee-Mis18 PF03226.9 EWC45135.1 - 2.2e-09 37.2 0.9 3e-09 36.8 0.1 1.6 2 0 0 2 2 2 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly RIG-I_C-RD PF11648.3 EWC45135.1 - 0.0036 17.1 0.1 0.0063 16.3 0.1 1.3 1 0 0 1 1 1 1 C-terminal domain of RIG-I CpXC PF14353.1 EWC45135.1 - 0.027 14.4 0.5 0.24 11.3 0.0 2.5 2 1 1 3 3 3 0 CpXC protein DUF3818 PF12825.2 EWC45135.1 - 0.095 11.3 0.3 0.14 10.7 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function in PX-proteins (DUF3818) GATase_4 PF13230.1 EWC45135.1 - 0.098 11.3 0.1 0.14 10.7 0.0 1.2 1 0 0 1 1 1 0 Glutamine amidotransferases class-II Rpr2 PF04032.11 EWC45135.1 - 0.1 12.4 2.4 0.11 12.3 0.1 2.2 2 1 0 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain DUF2296 PF10058.4 EWC45135.1 - 0.21 11.3 0.7 0.48 10.2 0.1 1.8 2 0 0 2 2 2 0 Predicted integral membrane metal-binding protein (DUF2296) DUF3818 PF12825.2 EWC45136.1 - 4.1e-134 446.5 2.9 5.6e-134 446.1 2.0 1.2 1 0 0 1 1 1 1 Domain of unknown function in PX-proteins (DUF3818) PXB PF12828.2 EWC45136.1 - 1.3e-43 147.8 1.0 2.9e-43 146.7 0.7 1.6 1 0 0 1 1 1 1 PX-associated PX PF00787.19 EWC45136.1 - 0.0023 17.7 2.0 0.032 14.0 1.4 2.7 1 1 0 1 1 1 1 PX domain PWI PF01480.12 EWC45137.1 - 1.1e-25 89.5 0.4 2e-25 88.7 0.3 1.4 1 0 0 1 1 1 1 PWI domain HSCB_C PF07743.8 EWC45137.1 - 4.8e-10 39.7 0.3 4.8e-10 39.7 0.2 2.4 2 0 0 2 2 2 1 HSCB C-terminal oligomerisation domain DnaJ PF00226.26 EWC45137.1 - 6e-07 29.0 0.0 1.7e-06 27.6 0.0 1.8 1 0 0 1 1 1 1 DnaJ domain FAM60A PF15396.1 EWC45137.1 - 0.00031 20.5 0.5 0.00065 19.5 0.3 1.5 1 0 0 1 1 1 1 Protein Family FAM60A DUF755 PF05501.6 EWC45137.1 - 0.0012 18.8 10.1 0.002 18.1 7.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF755) Pex14_N PF04695.8 EWC45137.1 - 0.03 14.3 3.9 0.051 13.6 2.7 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region SR-25 PF10500.4 EWC45137.1 - 0.037 13.4 11.0 0.077 12.4 7.6 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein TraV PF09676.5 EWC45137.1 - 0.043 14.5 3.2 0.095 13.3 2.2 1.6 1 0 0 1 1 1 0 Type IV conjugative transfer system lipoprotein (TraV) Tim54 PF11711.3 EWC45137.1 - 0.58 8.7 6.7 0.87 8.1 4.7 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 CAP_N PF01213.14 EWC45137.1 - 0.85 8.8 6.4 1.5 8.0 4.4 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal HEAT_2 PF13646.1 EWC45138.1 - 0.0011 19.2 0.3 0.0016 18.7 0.2 1.3 1 0 0 1 1 1 1 HEAT repeats LacI PF00356.16 EWC45138.1 - 0.057 13.0 0.8 0.15 11.6 0.1 2.0 2 0 0 2 2 2 0 Bacterial regulatory proteins, lacI family Nitroreductase PF00881.19 EWC45138.1 - 0.12 12.2 0.1 0.21 11.3 0.1 1.4 1 0 0 1 1 1 0 Nitroreductase family Phage_int_SAM_1 PF02899.12 EWC45138.1 - 0.49 10.5 3.0 0.85 9.8 2.0 1.4 1 1 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain Prenyltransf PF01255.14 EWC45139.1 - 8.3e-11 41.4 0.0 1.3e-08 34.2 0.0 2.2 2 0 0 2 2 2 2 Putative undecaprenyl diphosphate synthase Sybindin PF04099.7 EWC45140.1 - 1.8e-45 154.1 0.0 1.2e-44 151.4 0.0 1.9 1 1 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.8 EWC45140.1 - 5.8e-10 39.1 0.0 6.7e-10 38.9 0.0 1.1 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region P5CR_dimer PF14748.1 EWC45140.1 - 0.13 12.2 0.0 0.19 11.7 0.0 1.3 1 0 0 1 1 1 0 Pyrroline-5-carboxylate reductase dimerisation RNA_pol_Rpb4 PF03874.11 EWC45141.1 - 5.8e-24 84.3 0.6 7.4e-24 84.0 0.4 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb4 YqzH PF14164.1 EWC45141.1 - 0.091 12.6 0.0 5 7.1 0.0 2.4 2 0 0 2 2 2 0 YqzH-like protein ERO1 PF04137.10 EWC45142.1 - 3e-128 427.8 0.0 3.8e-128 427.5 0.0 1.1 1 0 0 1 1 1 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) DUF3635 PF12330.3 EWC45143.1 - 2.8e-10 40.1 1.9 2.5e-05 24.2 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF3635) APH PF01636.18 EWC45143.1 - 0.0002 21.1 0.2 0.0064 16.2 0.2 2.5 2 0 0 2 2 2 1 Phosphotransferase enzyme family TPT PF03151.11 EWC45144.1 - 1.1e-25 90.0 23.1 1.1e-24 86.8 5.5 2.1 2 0 0 2 2 2 2 Triose-phosphate Transporter family UAA PF08449.6 EWC45144.1 - 3.1e-11 42.7 20.8 1e-10 41.0 14.4 1.7 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.15 EWC45144.1 - 3.1e-05 23.9 29.4 0.00047 20.2 4.6 2.9 2 1 1 3 3 3 2 EamA-like transporter family Nuc_sug_transp PF04142.10 EWC45144.1 - 1.4 7.9 13.3 24 3.9 2.0 2.2 1 1 1 2 2 2 0 Nucleotide-sugar transporter GTP_EFTU PF00009.22 EWC45145.1 - 4.3e-42 143.6 0.2 8.2e-42 142.7 0.0 1.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.13 EWC45145.1 - 1e-27 96.0 0.0 2.1e-27 95.0 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.19 EWC45145.1 - 2.5e-18 65.6 0.0 5.8e-18 64.5 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.20 EWC45145.1 - 2.3e-11 43.6 0.1 5.9e-11 42.3 0.1 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.1 EWC45145.1 - 1.4e-07 31.2 0.0 3.2e-07 30.1 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II Miro PF08477.8 EWC45145.1 - 0.0011 19.3 0.0 0.0027 18.2 0.0 1.7 1 0 0 1 1 1 1 Miro-like protein Septin PF00735.13 EWC45145.1 - 0.16 10.9 0.0 0.26 10.2 0.0 1.2 1 0 0 1 1 1 0 Septin DUF59 PF01883.14 EWC45146.1 - 1.3e-05 25.0 0.0 3.5e-05 23.7 0.0 1.7 1 1 0 1 1 1 1 Domain of unknown function DUF59 Fungal_trans PF04082.13 EWC45147.1 - 1.1e-10 40.7 0.5 1.8e-10 40.1 0.4 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EWC45147.1 - 7.4e-07 28.9 9.4 1.5e-06 28.0 6.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Thiolase_N PF00108.18 EWC45148.1 - 6.3e-99 330.2 0.6 9.7e-99 329.6 0.4 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.13 EWC45148.1 - 6.2e-44 148.3 1.1 1.2e-43 147.4 0.7 1.5 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.21 EWC45148.1 - 0.00018 21.0 0.6 0.00052 19.5 0.4 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain DUF1992 PF09350.5 EWC45148.1 - 0.1 12.4 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1992) ACP_syn_III PF08545.5 EWC45148.1 - 0.19 11.4 5.2 0.74 9.5 0.1 3.2 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III GNAT_acetyltr_2 PF13718.1 EWC45149.1 - 9.3e-81 269.8 0.0 1.6e-80 269.0 0.0 1.4 1 0 0 1 1 1 1 GNAT acetyltransferase 2 Helicase_RecD PF05127.9 EWC45149.1 - 3.9e-65 218.7 2.1 1.4e-64 216.9 0.0 2.9 3 1 0 3 3 3 1 Helicase DUF1726 PF08351.6 EWC45149.1 - 1.8e-40 136.5 0.3 6.8e-40 134.6 0.1 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF1726) tRNA_bind_2 PF13725.1 EWC45149.1 - 3e-35 120.3 0.5 7.9e-35 118.9 0.3 1.7 1 0 0 1 1 1 1 Possible tRNA binding domain Acetyltransf_7 PF13508.1 EWC45149.1 - 0.00055 20.0 0.0 0.0031 17.6 0.0 2.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 EWC45149.1 - 0.0084 16.1 0.1 0.15 12.0 0.0 2.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family GHMP_kinases_N PF00288.21 EWC45149.1 - 0.025 14.6 1.3 1.4 9.0 0.0 2.7 2 0 0 2 2 2 0 GHMP kinases N terminal domain zf-B_box PF00643.19 EWC45150.1 - 0.029 14.2 7.2 0.043 13.7 5.0 1.2 1 0 0 1 1 1 0 B-box zinc finger zf-HIT PF04438.11 EWC45150.1 - 2 8.1 7.0 3.1 7.5 4.8 1.2 1 0 0 1 1 1 0 HIT zinc finger DUF2401 PF10287.4 EWC45151.1 - 8e-67 225.1 0.9 1.1e-66 224.6 0.6 1.2 1 0 0 1 1 1 1 Putative TOS1-like glycosyl hydrolase (DUF2401) DUF2403 PF10290.4 EWC45151.1 - 5.4e-14 52.1 0.2 5.4e-14 52.1 0.1 2.5 3 0 0 3 3 3 1 Glycine-rich protein domain (DUF2403) RyR PF02026.11 EWC45152.1 - 2.5e-14 53.0 0.1 1.5e-10 40.9 0.0 2.2 2 0 0 2 2 2 2 RyR domain CorA PF01544.13 EWC45153.1 - 1e-05 24.7 7.3 2.1e-05 23.6 5.0 1.4 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein EMP70 PF02990.11 EWC45153.1 - 0.018 13.5 0.4 0.026 12.9 0.3 1.1 1 0 0 1 1 1 0 Endomembrane protein 70 RyR PF02026.11 EWC45154.1 - 1.1e-07 31.7 0.7 0.0036 17.2 0.1 2.5 2 0 0 2 2 2 2 RyR domain HET PF06985.6 EWC45155.1 - 8.1e-33 113.5 0.1 1.3e-32 112.8 0.0 1.3 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) CPSF_A PF03178.10 EWC45157.1 - 6.6e-78 262.0 0.0 3.2e-77 259.7 0.0 2.1 2 0 0 2 2 2 1 CPSF A subunit region MMS1_N PF10433.4 EWC45157.1 - 9.6e-06 23.9 0.0 0.001 17.2 0.0 2.4 2 0 0 2 2 2 2 Mono-functional DNA-alkylating methyl methanesulfonate N-term F_actin_cap_B PF01115.12 EWC45158.1 - 8.7e-111 368.9 0.0 1e-110 368.6 0.0 1.0 1 0 0 1 1 1 1 F-actin capping protein, beta subunit F-actin_cap_A PF01267.12 EWC45158.1 - 0.00042 19.4 0.0 0.0015 17.6 0.0 1.9 1 1 1 2 2 2 2 F-actin capping protein alpha subunit TFIIS_M PF07500.9 EWC45159.1 - 3.6e-34 117.2 2.4 4.5e-34 116.9 0.6 1.8 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.13 EWC45159.1 - 6.8e-19 67.2 3.8 1.1e-18 66.5 2.6 1.4 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Med26 PF08711.6 EWC45159.1 - 2.4e-14 52.5 1.1 4.9e-14 51.5 0.3 2.0 2 0 0 2 2 2 1 TFIIS helical bundle-like domain DNA_RNApol_7kD PF03604.8 EWC45159.1 - 0.2 11.1 5.1 0.75 9.3 0.1 2.5 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit CaM_bdg_C0 PF10562.4 EWC45159.1 - 0.22 11.4 1.4 0.3 10.9 0.1 1.9 2 0 0 2 2 2 0 Calmodulin-binding domain C0 of NMDA receptor NR1 subunit Methyltransf_28 PF02636.12 EWC45160.1 - 1.6e-32 112.9 0.0 2.4e-32 112.3 0.0 1.3 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_25 PF13649.1 EWC45160.1 - 0.04 14.2 0.0 0.14 12.5 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain RrnaAD PF00398.15 EWC45160.1 - 0.047 12.7 0.0 0.091 11.7 0.0 1.4 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Methyltransf_32 PF13679.1 EWC45160.1 - 0.21 11.2 0.0 0.36 10.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain PALP PF00291.20 EWC45161.1 - 2.2e-56 191.3 0.1 3.1e-56 190.8 0.1 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Scm3 PF10384.4 EWC45162.1 - 2.2e-18 65.5 0.1 4.6e-18 64.4 0.1 1.5 1 0 0 1 1 1 1 Centromere protein Scm3 KIF1B PF12423.3 EWC45162.1 - 0.093 12.7 2.7 0.15 12.1 0.8 2.1 2 0 0 2 2 2 0 Kinesin protein 1B Golgin_A5 PF09787.4 EWC45162.1 - 1.7 7.0 9.0 1 7.8 0.1 2.2 2 0 0 2 2 2 0 Golgin subfamily A member 5 CorA PF01544.13 EWC45163.1 - 2.8e-05 23.3 0.0 5.1e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein DUF1512 PF07431.7 EWC45163.1 - 0.3 9.7 1.0 0.5 9.0 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1512) Aldolase_II PF00596.16 EWC45164.1 - 6.1e-44 149.8 0.1 7.2e-44 149.5 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Calreticulin PF00262.13 EWC45165.1 - 8.1e-158 524.8 10.8 1.2e-157 524.2 7.5 1.3 1 0 0 1 1 1 1 Calreticulin family Aldedh PF00171.17 EWC45166.1 - 3.1e-124 414.8 1.1 8.5e-123 410.0 0.8 2.0 1 1 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.9 EWC45166.1 - 0.087 11.5 0.0 0.15 10.7 0.0 1.3 1 0 0 1 1 1 0 Acyl-CoA reductase (LuxC) VMA21 PF09446.5 EWC45167.1 - 7.1e-11 41.8 5.1 1.2e-10 41.1 3.5 1.3 1 0 0 1 1 1 1 VMA21-like domain SNF2_N PF00176.18 EWC45168.1 - 9.2e-56 188.8 0.0 1.4e-55 188.2 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 EWC45168.1 - 4.5e-11 42.4 0.0 1.2e-10 41.0 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 EWC45168.1 - 6.7e-05 22.4 0.0 0.00016 21.1 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase MFS_1 PF07690.11 EWC45169.1 - 1.2e-46 159.1 30.5 1.4e-40 139.1 17.4 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EWC45169.1 - 2.3e-07 29.7 31.6 5.9e-05 21.8 2.5 3.8 2 2 2 4 4 4 3 Sugar (and other) transporter Abhydrolase_6 PF12697.2 EWC45170.1 - 8.4e-22 78.1 1.7 1.7e-21 77.1 1.2 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EWC45170.1 - 1.4e-10 41.1 0.2 3.3e-10 39.8 0.1 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EWC45170.1 - 1.9e-08 34.1 0.0 0.0022 17.5 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Thioesterase PF00975.15 EWC45170.1 - 7.6e-05 23.0 0.0 0.00015 22.0 0.0 1.5 1 0 0 1 1 1 1 Thioesterase domain Hydrolase_4 PF12146.3 EWC45170.1 - 0.011 15.5 0.0 0.021 14.6 0.0 1.4 1 0 0 1 1 1 0 Putative lysophospholipase Lipase_3 PF01764.20 EWC45170.1 - 0.031 13.9 0.0 0.051 13.2 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) DUF676 PF05057.9 EWC45170.1 - 0.098 11.9 0.0 0.15 11.3 0.0 1.2 1 0 0 1 1 1 0 Putative serine esterase (DUF676) DUF3602 PF12223.3 EWC45171.1 - 4.1e-08 33.5 20.1 0.002 18.4 3.7 3.4 1 1 2 3 3 3 3 Protein of unknown function (DUF3602) Rotamase_3 PF13616.1 EWC45173.1 - 1.1e-19 70.8 0.0 1.5e-19 70.3 0.0 1.4 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase PF00639.16 EWC45173.1 - 3.9e-18 65.9 0.1 9.9e-18 64.6 0.0 1.7 2 0 0 2 2 2 1 PPIC-type PPIASE domain Rotamase_2 PF13145.1 EWC45173.1 - 7.2e-06 26.6 0.0 7.8e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain Helicase_C PF00271.26 EWC45174.1 - 8.8e-21 73.5 0.1 2.2e-20 72.2 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EWC45174.1 - 5.9e-19 68.6 0.5 1.6e-18 67.1 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.24 EWC45174.1 - 6e-19 68.1 0.0 1.6e-18 66.7 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 EWC45174.1 - 0.058 13.5 0.0 0.16 12.0 0.0 1.9 1 0 0 1 1 1 0 AAA domain Apolipoprotein PF01442.13 EWC45175.1 - 0.00024 20.7 3.9 0.034 13.6 2.7 2.6 1 1 0 1 1 1 1 Apolipoprotein A1/A4/E domain DUF883 PF05957.8 EWC45175.1 - 0.0087 16.4 16.4 0.54 10.6 0.4 5.2 2 2 3 5 5 5 1 Bacterial protein of unknown function (DUF883) DUF4618 PF15397.1 EWC45175.1 - 0.011 15.1 6.3 0.062 12.6 0.1 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4618) Dynamin_M PF01031.15 EWC45175.1 - 0.023 13.4 0.4 0.21 10.3 0.1 2.2 2 0 0 2 2 2 0 Dynamin central region ISG65-75 PF11727.3 EWC45175.1 - 0.026 13.5 28.8 0.069 12.1 4.3 3.4 2 1 1 3 3 3 0 Invariant surface glycoprotein HisKA_3 PF07730.8 EWC45175.1 - 0.062 13.6 1.4 6.9 7.0 0.0 3.7 4 2 0 4 4 3 0 Histidine kinase Baculo_PEP_C PF04513.7 EWC45175.1 - 0.063 13.0 13.4 1.7 8.4 0.9 3.4 2 2 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Tweety PF04906.8 EWC45175.1 - 0.15 10.4 8.2 0.39 9.0 0.3 2.9 1 1 2 3 3 3 0 Tweety COG5 PF10392.4 EWC45175.1 - 0.17 11.8 0.8 4.7 7.1 0.1 2.6 3 0 0 3 3 3 0 Golgi transport complex subunit 5 Prominin PF05478.6 EWC45175.1 - 0.32 8.4 10.9 0.74 7.2 7.6 1.6 1 1 0 1 1 1 0 Prominin Topo-VIb_trans PF09239.6 EWC45175.1 - 1.7 8.1 6.3 9.1 5.7 0.1 3.2 3 0 0 3 3 3 0 Topoisomerase VI B subunit, transducer YtxH PF12732.2 EWC45175.1 - 8.2 6.8 32.9 2.3e+02 2.2 2.1 5.3 2 2 0 2 2 1 0 YtxH-like protein DUF1179 PF06678.6 EWC45176.1 - 0.7 10.2 4.3 4.3 7.6 0.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1179) AAA PF00004.24 EWC45177.1 - 2.3e-17 63.4 0.0 4.8e-17 62.3 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.1 EWC45177.1 - 4.8e-16 58.8 0.0 1e-15 57.7 0.0 1.6 2 0 0 2 2 1 1 DNA polymerase III, delta subunit Rad17 PF03215.10 EWC45177.1 - 3.3e-11 42.5 0.0 7.1e-08 31.5 0.0 2.2 1 1 1 2 2 2 2 Rad17 cell cycle checkpoint protein Rep_fac_C PF08542.6 EWC45177.1 - 1.8e-08 34.2 0.0 5.6e-08 32.6 0.0 1.9 2 0 0 2 2 1 1 Replication factor C C-terminal domain AAA_22 PF13401.1 EWC45177.1 - 1.6e-06 28.2 0.0 9.7e-06 25.7 0.0 2.1 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.7 EWC45177.1 - 9.1e-06 24.8 0.0 2.2e-05 23.6 0.0 1.6 2 0 0 2 2 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_14 PF13173.1 EWC45177.1 - 1.3e-05 25.0 0.0 3.1e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 EWC45177.1 - 1.7e-05 24.5 0.0 2.6e-05 23.9 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 EWC45177.1 - 2.4e-05 23.9 0.0 5.3e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 Part of AAA domain AAA_16 PF13191.1 EWC45177.1 - 2.6e-05 24.3 0.0 0.00043 20.3 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain DUF2075 PF09848.4 EWC45177.1 - 0.00023 20.2 0.0 0.00036 19.6 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.1 EWC45177.1 - 0.00031 20.3 0.0 0.00089 18.8 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.1 EWC45177.1 - 0.00049 19.7 1.0 0.0048 16.5 0.3 2.4 2 1 0 2 2 2 1 AAA domain DUF815 PF05673.8 EWC45177.1 - 0.00056 18.9 0.0 0.0009 18.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF815) Mg_chelatase PF01078.16 EWC45177.1 - 0.00061 19.0 0.0 0.01 15.0 0.0 2.2 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 EWC45177.1 - 0.0016 18.1 0.0 0.0038 16.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_17 PF13207.1 EWC45177.1 - 0.0018 19.1 0.0 0.0038 18.0 0.0 1.7 1 1 0 1 1 1 1 AAA domain FtsK_SpoIIIE PF01580.13 EWC45177.1 - 0.0041 16.6 0.1 0.061 12.8 0.0 2.3 1 1 1 2 2 2 1 FtsK/SpoIIIE family AAA_25 PF13481.1 EWC45177.1 - 0.0099 15.2 0.6 0.04 13.3 0.1 2.3 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.1 EWC45177.1 - 0.022 15.0 0.0 0.045 14.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain DNA_pol3_delta PF06144.8 EWC45177.1 - 0.027 14.0 0.0 0.05 13.1 0.0 1.4 1 0 0 1 1 1 0 DNA polymerase III, delta subunit AAA_28 PF13521.1 EWC45177.1 - 0.028 14.3 0.0 0.048 13.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain Arch_ATPase PF01637.13 EWC45177.1 - 0.034 13.8 0.0 0.068 12.8 0.0 1.5 1 1 0 1 1 1 0 Archaeal ATPase AAA_33 PF13671.1 EWC45177.1 - 0.038 13.8 0.0 0.094 12.5 0.0 1.8 1 1 0 1 1 1 0 AAA domain ResIII PF04851.10 EWC45177.1 - 0.054 13.3 0.0 0.19 11.5 0.0 1.9 2 1 0 2 2 1 0 Type III restriction enzyme, res subunit AAA_3 PF07726.6 EWC45177.1 - 0.075 12.6 0.0 0.43 10.1 0.0 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.17 EWC45177.1 - 0.078 13.1 0.0 0.19 11.9 0.0 1.8 1 1 0 1 1 1 0 RNA helicase AAA_10 PF12846.2 EWC45177.1 - 0.084 12.2 0.0 0.97 8.8 0.0 2.2 1 1 1 2 2 2 0 AAA-like domain PhoH PF02562.11 EWC45177.1 - 0.11 11.7 0.1 4.6 6.4 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein TK PF00265.13 EWC45177.1 - 0.11 11.9 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 Thymidine kinase SNF2_N PF00176.18 EWC45177.1 - 0.13 11.0 0.0 2.5 6.7 0.0 2.1 1 1 0 2 2 2 0 SNF2 family N-terminal domain DUF1746 PF08508.5 EWC45178.1 - 1.9e-34 118.0 1.5 2.9e-34 117.4 1.1 1.3 1 0 0 1 1 1 1 Fungal domain of unknown function (DUF1746) DUF1980 PF09323.5 EWC45178.1 - 0.049 13.3 0.1 0.13 11.9 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) SRP14 PF02290.10 EWC45179.1 - 1e-19 70.2 0.0 1.1e-11 44.5 0.0 2.3 1 1 1 2 2 2 2 Signal recognition particle 14kD protein Amino_oxidase PF01593.19 EWC45180.1 - 3.2e-90 303.3 0.0 8.7e-90 301.9 0.0 1.7 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase SWIRM PF04433.12 EWC45180.1 - 4.3e-11 42.8 0.1 8.4e-11 41.8 0.0 1.5 1 0 0 1 1 1 1 SWIRM domain NAD_binding_8 PF13450.1 EWC45180.1 - 1.2e-08 34.8 0.4 2.7e-08 33.7 0.3 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HMG_box PF00505.14 EWC45180.1 - 0.00079 19.6 1.7 0.0025 18.0 1.2 2.0 1 1 0 1 1 1 1 HMG (high mobility group) box DAO PF01266.19 EWC45180.1 - 0.00084 18.3 0.3 0.023 13.6 0.4 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 EWC45180.1 - 0.0012 18.8 0.2 1.7 8.6 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 EWC45180.1 - 0.0019 17.9 0.2 0.13 12.0 0.1 2.6 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.9 EWC45180.1 - 0.027 14.3 0.2 0.62 9.9 0.1 2.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Fasciclin PF02469.17 EWC45181.1 - 0.0012 18.8 0.0 0.0018 18.2 0.0 1.3 1 0 0 1 1 1 1 Fasciclin domain Pkinase PF00069.20 EWC45182.1 - 1.7e-59 201.0 0.1 2e-59 200.8 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC45182.1 - 4.7e-18 65.1 0.0 6.9e-18 64.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 EWC45182.1 - 9.7e-08 32.0 0.0 1.2e-05 25.1 0.0 2.5 1 1 1 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 EWC45182.1 - 0.0089 15.6 0.0 0.023 14.2 0.0 1.7 1 0 0 1 1 1 1 Choline/ethanolamine kinase Kdo PF06293.9 EWC45182.1 - 0.045 12.8 0.1 0.084 11.9 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 EWC45182.1 - 0.066 12.1 0.0 0.11 11.4 0.0 1.3 1 0 0 1 1 1 0 Kinase-like BolA PF01722.13 EWC45182.1 - 0.08 12.9 0.0 5.1 7.1 0.0 2.3 2 0 0 2 2 2 0 BolA-like protein YrbL-PhoP_reg PF10707.4 EWC45182.1 - 0.11 11.8 0.3 5.8 6.2 0.0 2.4 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL Vert_HS_TF PF06546.6 EWC45182.1 - 0.18 11.2 0.0 0.27 10.6 0.0 1.2 1 0 0 1 1 1 0 Vertebrate heat shock transcription factor Pal1 PF08316.6 EWC45184.1 - 9.4e-10 39.0 2.2 1.1e-09 38.8 0.1 2.3 3 0 0 3 3 3 1 Pal1 cell morphology protein HVSL PF09749.4 EWC45186.1 - 3.3e-62 209.6 0.0 4.2e-62 209.2 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised conserved protein CDP-OH_P_transf PF01066.16 EWC45186.1 - 3e-17 62.7 1.3 1e-16 61.0 0.9 2.0 1 0 0 1 1 1 1 CDP-alcohol phosphatidyltransferase Peptidase_S8 PF00082.17 EWC45187.1 - 9.1e-57 192.3 3.4 9.1e-57 192.3 2.4 2.1 2 0 0 2 2 2 1 Subtilase family P_proprotein PF01483.15 EWC45187.1 - 5.6e-28 96.5 0.8 5.6e-28 96.5 0.5 1.7 2 0 0 2 2 2 1 Proprotein convertase P-domain MFS_2 PF13347.1 EWC45189.1 - 1.9e-08 33.1 15.0 1.9e-08 33.1 10.4 2.6 2 1 1 3 3 3 1 MFS/sugar transport protein MFS_1_like PF12832.2 EWC45189.1 - 0.0009 18.9 2.1 0.17 11.6 0.0 3.2 2 0 0 2 2 2 2 MFS_1 like family DUF1228 PF06779.9 EWC45189.1 - 0.15 12.0 9.4 0.58 10.2 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1228) G6PD_C PF02781.11 EWC45190.1 - 3.8e-133 442.8 0.0 5.6e-133 442.3 0.0 1.2 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.17 EWC45190.1 - 1.1e-62 211.5 0.0 1.7e-62 210.8 0.0 1.3 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain PEP-utilisers_N PF05524.8 EWC45191.1 - 0.018 14.7 1.6 0.34 10.6 0.5 2.6 2 1 0 2 2 2 0 PEP-utilising enzyme, N-terminal Cauli_DNA-bind PF03310.8 EWC45191.1 - 0.14 11.9 5.6 0.36 10.6 2.0 2.6 2 1 0 2 2 2 0 Caulimovirus DNA-binding protein DUF3802 PF12290.3 EWC45191.1 - 0.17 12.1 2.8 0.39 11.0 1.9 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3802) LXG PF04740.7 EWC45191.1 - 0.63 9.7 7.0 0.3 10.8 2.6 1.9 2 0 0 2 2 2 0 LXG domain of WXG superfamily Reo_sigmaC PF04582.7 EWC45191.1 - 0.92 8.6 5.9 0.58 9.2 2.1 1.7 1 1 0 1 1 1 0 Reovirus sigma C capsid protein TMF_TATA_bd PF12325.3 EWC45191.1 - 1.1 8.9 9.9 0.48 10.1 2.7 2.4 2 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF948 PF06103.6 EWC45191.1 - 3.3 7.6 8.0 4.6 7.1 0.6 2.5 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF4611 PF15387.1 EWC45191.1 - 4.5 7.4 20.9 7.6 6.7 3.3 4.2 2 1 2 4 4 4 0 Domain of unknown function (DUF4611) ISG65-75 PF11727.3 EWC45191.1 - 6.1 5.8 8.2 0.81 8.6 2.4 1.7 1 1 1 2 2 2 0 Invariant surface glycoprotein XhlA PF10779.4 EWC45191.1 - 6.9 6.6 8.0 6.6 6.7 0.1 3.1 2 1 0 2 2 2 0 Haemolysin XhlA 14-3-3 PF00244.15 EWC45192.1 - 1.2e-10 40.9 0.1 2e-10 40.1 0.1 1.3 1 0 0 1 1 1 1 14-3-3 protein LIM PF00412.17 EWC45194.1 - 7.4e-28 96.4 38.2 1.1e-09 38.2 8.3 3.5 3 0 0 3 3 3 3 LIM domain Leader_Erm PF08253.6 EWC45194.1 - 0.051 13.0 0.5 0.092 12.2 0.4 1.4 1 0 0 1 1 1 0 Erm Leader peptide Asn_synthase PF00733.16 EWC45195.1 - 3.1e-48 164.4 0.0 4.2e-48 164.0 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.1 EWC45195.1 - 1.5e-07 31.1 0.0 4.1e-07 29.7 0.0 1.7 1 1 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.1 EWC45195.1 - 1.5e-06 28.2 0.0 2.7e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain ABC_tran PF00005.22 EWC45196.1 - 8e-33 113.6 0.0 1.7e-32 112.5 0.0 1.6 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.18 EWC45196.1 - 1.1e-29 103.7 8.9 1.1e-29 103.7 6.2 1.9 2 0 0 2 2 2 1 ABC transporter transmembrane region SMC_N PF02463.14 EWC45196.1 - 1.3e-07 31.1 0.0 5.4e-07 29.0 0.0 1.8 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 EWC45196.1 - 6.9e-07 29.5 0.1 0.00049 20.1 0.1 2.5 1 1 0 1 1 1 1 AAA domain SbcCD_C PF13558.1 EWC45196.1 - 0.0028 17.5 0.2 0.058 13.3 0.1 3.1 2 1 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA PF00004.24 EWC45196.1 - 0.012 15.8 0.2 0.081 13.1 0.2 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 EWC45196.1 - 0.015 15.4 0.3 0.12 12.5 0.2 2.2 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.1 EWC45196.1 - 0.018 15.0 0.0 0.047 13.6 0.0 1.7 1 1 0 1 1 1 0 AAA ATPase domain DUF258 PF03193.11 EWC45196.1 - 0.07 12.3 0.0 0.15 11.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_29 PF13555.1 EWC45196.1 - 0.091 12.2 0.2 0.31 10.5 0.1 1.9 1 0 0 1 1 1 0 P-loop containing region of AAA domain AFG1_ATPase PF03969.11 EWC45197.1 - 1.9e-53 181.5 0.0 5.2e-51 173.5 0.0 2.7 2 1 0 2 2 2 1 AFG1-like ATPase AAA_16 PF13191.1 EWC45197.1 - 7e-05 22.8 4.1 0.033 14.1 1.2 3.0 2 1 1 3 3 3 2 AAA ATPase domain AAA_5 PF07728.9 EWC45197.1 - 0.00017 21.3 0.0 0.00039 20.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA PF00004.24 EWC45197.1 - 0.00045 20.4 0.0 0.0011 19.1 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 EWC45197.1 - 0.0007 19.7 0.0 0.018 15.1 0.0 2.8 2 1 0 2 2 2 1 AAA domain AAA_14 PF13173.1 EWC45197.1 - 0.0023 17.8 0.0 0.0091 15.8 0.0 1.9 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.16 EWC45197.1 - 0.0039 16.3 0.0 0.015 14.4 0.0 1.8 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.7 EWC45197.1 - 0.0085 15.2 0.0 0.016 14.3 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_17 PF13207.1 EWC45197.1 - 0.015 16.1 0.0 0.066 14.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.1 EWC45197.1 - 0.075 13.3 0.0 0.19 12.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.1 EWC45197.1 - 0.091 12.3 0.0 0.25 10.8 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain Matrilin_ccoil PF10393.4 EWC45197.1 - 0.2 11.0 0.1 0.36 10.2 0.1 1.4 1 0 0 1 1 1 0 Trimeric coiled-coil oligomerisation domain of matrilin SOG2 PF10428.4 EWC45198.1 - 0.0082 14.8 20.4 0.0099 14.5 8.6 2.3 2 0 0 2 2 2 2 RAM signalling pathway protein PARP PF00644.15 EWC45200.1 - 0.0012 18.2 0.2 0.014 14.8 0.0 2.7 1 1 1 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain Glyco_hydro_76 PF03663.9 EWC45201.1 - 8.6e-147 489.3 15.5 1.1e-146 488.9 10.7 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Lipase_GDSL_2 PF13472.1 EWC45202.1 - 8.5e-07 29.2 0.0 1.1e-06 28.8 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.17 EWC45202.1 - 0.00073 19.4 0.3 0.0013 18.6 0.2 1.6 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Phage_GPA PF05840.8 EWC45203.1 - 0.0023 16.7 0.0 0.0036 16.0 0.0 1.2 1 0 0 1 1 1 1 Bacteriophage replication gene A protein (GPA) MFS_1 PF07690.11 EWC45204.1 - 1.8e-28 99.2 37.9 1.8e-28 99.2 26.3 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily Mannosyl_trans2 PF04188.8 EWC45205.1 - 1.1e-57 195.9 6.2 2.1e-57 195.0 4.3 1.4 1 1 0 1 1 1 1 Mannosyltransferase (PIG-V)) Kelch_5 PF13854.1 EWC45206.1 - 3e-17 62.1 10.9 2e-10 40.3 0.0 5.4 5 0 0 5 5 5 3 Kelch motif Kelch_4 PF13418.1 EWC45206.1 - 1.6e-15 56.5 9.6 0.0013 18.4 0.1 6.7 5 2 1 6 6 6 4 Galactose oxidase, central domain Kelch_3 PF13415.1 EWC45206.1 - 3.6e-15 55.6 13.8 0.0027 17.8 0.1 6.8 6 1 0 6 6 6 5 Galactose oxidase, central domain Kelch_6 PF13964.1 EWC45206.1 - 1.4e-09 37.7 16.0 0.22 11.7 0.1 6.8 6 1 0 6 6 6 3 Kelch motif Kelch_2 PF07646.10 EWC45206.1 - 3.1e-06 26.7 7.5 0.0048 16.6 0.0 5.8 6 0 0 6 6 6 1 Kelch motif Kelch_1 PF01344.20 EWC45206.1 - 1.8e-05 24.1 15.3 0.0041 16.6 0.1 5.7 6 1 0 6 6 6 2 Kelch motif Rax2 PF12768.2 EWC45206.1 - 0.015 14.5 7.6 0.016 14.4 0.4 3.3 3 1 0 4 4 4 0 Cortical protein marker for cell polarity DUF1049 PF06305.6 EWC45206.1 - 0.088 12.3 0.2 0.16 11.4 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) EphA2_TM PF14575.1 EWC45206.1 - 0.21 11.9 0.0 0.48 10.8 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Ten1 PF12658.2 EWC45207.1 - 0.00042 20.0 0.0 0.0006 19.5 0.0 1.2 1 0 0 1 1 1 1 Telomere capping, CST complex subunit Rep_fac-A_3 PF08661.6 EWC45207.1 - 0.048 13.5 0.1 0.059 13.2 0.0 1.4 1 1 0 1 1 1 0 Replication factor A protein 3 Fork_head PF00250.13 EWC45208.1 - 7.8e-17 61.0 0.0 2e-16 59.8 0.0 1.6 1 0 0 1 1 1 1 Fork head domain FHA PF00498.21 EWC45208.1 - 0.00052 20.0 0.0 0.0018 18.3 0.0 1.9 2 0 0 2 2 2 1 FHA domain Trehalase PF01204.13 EWC45210.1 - 1.5e-185 617.6 0.0 1.8e-185 617.4 0.0 1.0 1 0 0 1 1 1 1 Trehalase Trehalase_Ca-bi PF07492.6 EWC45210.1 - 1.7e-16 59.2 0.8 2.9e-16 58.4 0.6 1.4 1 0 0 1 1 1 1 Neutral trehalase Ca2+ binding domain cNMP_binding PF00027.24 EWC45211.1 - 1.6e-42 143.2 0.0 3.3e-22 78.0 0.0 2.5 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain RIIa PF02197.12 EWC45211.1 - 7.8e-12 44.4 0.8 1.8e-11 43.2 0.6 1.6 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit BCAS2 PF05700.6 EWC45212.1 - 1.8e-48 164.9 0.0 1.9e-48 164.8 0.0 1.0 1 0 0 1 1 1 1 Breast carcinoma amplified sequence 2 (BCAS2) Rox3 PF08633.5 EWC45213.1 - 5.7e-27 95.2 3.7 2.9e-26 92.9 0.0 2.7 2 1 0 2 2 2 1 Rox3 mediator complex subunit Ribosomal_L35Ae PF01247.13 EWC45215.1 - 3.7e-42 142.0 0.6 4.7e-42 141.6 0.4 1.1 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.13 EWC45215.1 - 0.004 17.0 0.1 0.98 9.3 0.0 2.2 2 0 0 2 2 2 2 RimM N-terminal domain SDP_N PF12278.3 EWC45215.1 - 0.031 13.9 0.1 0.037 13.6 0.1 1.1 1 0 0 1 1 1 0 Sex determination protein N terminal HA2 PF04408.18 EWC45216.1 - 7.9e-25 86.8 0.0 3.2e-24 84.8 0.0 2.1 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.11 EWC45216.1 - 2e-22 79.1 0.0 8e-22 77.2 0.0 2.0 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.26 EWC45216.1 - 2.8e-12 46.3 0.0 6.6e-12 45.1 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 EWC45216.1 - 2.2e-07 30.5 0.1 9.9e-07 28.3 0.1 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.1 EWC45216.1 - 2.4e-05 24.4 0.1 0.00012 22.2 0.0 2.2 2 0 0 2 2 2 1 AAA domain T2SE PF00437.15 EWC45216.1 - 0.00055 18.9 0.0 0.0016 17.3 0.0 1.7 1 0 0 1 1 1 1 Type II/IV secretion system protein Flavi_DEAD PF07652.9 EWC45216.1 - 0.0046 16.7 0.1 0.0086 15.8 0.1 1.4 1 0 0 1 1 1 1 Flavivirus DEAD domain ResIII PF04851.10 EWC45216.1 - 0.0079 16.0 0.0 1.4 8.6 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit KaiC PF06745.8 EWC45216.1 - 0.0092 15.1 0.0 0.019 14.1 0.0 1.4 1 0 0 1 1 1 1 KaiC DUF2075 PF09848.4 EWC45216.1 - 0.0096 14.9 0.0 0.016 14.1 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) SRP54 PF00448.17 EWC45216.1 - 0.012 15.0 0.2 0.028 13.8 0.2 1.6 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_14 PF13173.1 EWC45216.1 - 0.024 14.5 0.1 0.14 12.0 0.1 2.2 1 1 0 1 1 1 0 AAA domain NB-ARC PF00931.17 EWC45216.1 - 0.064 12.0 0.1 0.11 11.2 0.1 1.3 1 0 0 1 1 1 0 NB-ARC domain NACHT PF05729.7 EWC45216.1 - 0.097 12.3 0.4 0.37 10.4 0.3 1.9 1 1 0 1 1 1 0 NACHT domain Arch_ATPase PF01637.13 EWC45216.1 - 0.26 10.9 1.0 0.44 10.2 0.0 1.9 2 0 0 2 2 2 0 Archaeal ATPase Nop14 PF04147.7 EWC45217.1 - 1.4e-250 833.7 27.2 4.5e-250 832.0 18.8 1.7 1 1 0 1 1 1 1 Nop14-like family RNase_P_p30 PF01876.11 EWC45218.1 - 1.8e-50 170.0 0.2 2.6e-50 169.5 0.1 1.2 1 0 0 1 1 1 1 RNase P subunit p30 SRF-TF PF00319.13 EWC45219.1 - 5.6e-23 79.9 0.2 8.7e-23 79.3 0.2 1.3 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) AvrE PF11725.3 EWC45219.1 - 0.04 10.9 12.5 0.049 10.6 8.6 1.1 1 0 0 1 1 1 0 Pathogenicity factor LIM_bind PF01803.11 EWC45219.1 - 0.39 9.7 18.8 4.8 6.2 12.2 2.3 2 0 0 2 2 2 0 LIM-domain binding protein Neur_chan_memb PF02932.11 EWC45219.1 - 5.7 6.7 8.6 1 9.2 3.3 1.8 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Ndc1_Nup PF09531.5 EWC45219.1 - 6.8 4.9 11.8 8.9 4.6 8.2 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup RRF PF01765.14 EWC45220.1 - 4.2e-26 91.3 1.1 7.9e-26 90.4 0.8 1.4 1 0 0 1 1 1 1 Ribosome recycling factor MFS_1 PF07690.11 EWC45221.1 - 1.4e-48 165.4 48.9 1.4e-48 165.4 33.9 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.8 EWC45221.1 - 4.2e-26 91.3 29.4 1.5e-25 89.4 20.4 1.7 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.19 EWC45221.1 - 1e-12 47.4 16.2 1e-12 47.4 11.2 2.8 1 1 1 3 3 3 2 Sugar (and other) transporter RRN3 PF05327.6 EWC45222.1 - 9e-157 522.5 0.0 1.2e-156 522.1 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor RRN3 Pkinase PF00069.20 EWC45223.1 - 9.4e-65 218.3 0.0 1.2e-64 217.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC45223.1 - 1.7e-47 161.6 0.0 2.6e-47 161.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EWC45223.1 - 1.6e-07 30.6 0.1 1.2e-06 27.7 0.0 2.0 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 EWC45223.1 - 0.028 14.1 0.0 1.1 8.9 0.0 2.4 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.9 EWC45223.1 - 0.22 10.5 0.0 0.48 9.4 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Telomere_reg-2 PF10193.4 EWC45224.1 - 6e-32 110.2 0.1 5.7e-31 107.1 0.0 2.3 2 0 0 2 2 2 1 Telomere length regulation protein DUF2406 PF10295.4 EWC45225.1 - 3.5e-17 62.6 0.3 3.5e-17 62.6 0.2 3.3 2 1 0 2 2 2 1 Uncharacterised protein (DUF2406) PAT1 PF09770.4 EWC45225.1 - 1.8 6.6 29.2 2.1 6.4 20.3 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 APG6 PF04111.7 EWC45226.1 - 1.4e-129 431.7 0.7 1.8e-129 431.3 0.5 1.1 1 0 0 1 1 1 1 Autophagy protein Apg6 V_ATPase_I PF01496.14 EWC45226.1 - 0.00019 19.4 5.1 0.00027 18.9 3.5 1.1 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family IncA PF04156.9 EWC45226.1 - 0.0009 18.8 10.6 0.0009 18.8 7.3 2.1 2 0 0 2 2 2 1 IncA protein zf-C4H2 PF10146.4 EWC45226.1 - 0.0041 17.1 4.5 0.021 14.8 3.3 2.0 2 0 0 2 2 2 1 Zinc finger-containing protein AAA_13 PF13166.1 EWC45226.1 - 0.011 14.2 7.4 0.017 13.6 5.1 1.2 1 0 0 1 1 1 0 AAA domain DUF342 PF03961.8 EWC45226.1 - 0.038 12.4 6.1 0.057 11.8 4.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DUF3142 PF11340.3 EWC45226.1 - 0.063 12.9 0.8 1.8 8.1 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3142) DUF972 PF06156.8 EWC45226.1 - 1.8 8.9 12.5 0.067 13.5 3.6 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF972) DUF4337 PF14235.1 EWC45226.1 - 2.7 7.7 14.4 6.3 6.6 10.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) Atg14 PF10186.4 EWC45227.1 - 1.4e-48 165.4 2.7 2e-48 164.9 1.9 1.2 1 0 0 1 1 1 1 UV radiation resistance protein and autophagy-related subunit 14 tRNA-synt_His PF13393.1 EWC45227.1 - 1e-38 133.1 0.6 9.6e-33 113.5 0.0 2.9 3 0 0 3 3 3 2 Histidyl-tRNA synthetase tRNA-synt_2b PF00587.20 EWC45227.1 - 3.7e-17 62.4 0.0 6.7e-17 61.6 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 EWC45227.1 - 6e-09 35.7 0.0 1.3e-08 34.6 0.0 1.6 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2 PF00152.15 EWC45227.1 - 0.0013 17.6 0.0 0.26 10.0 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class II (D, K and N) Spectrin PF00435.16 EWC45227.1 - 0.0035 17.5 2.0 0.02 15.1 0.7 2.3 2 0 0 2 2 2 1 Spectrin repeat Streptin-Immun PF11083.3 EWC45227.1 - 0.036 14.0 0.5 0.083 12.8 0.3 1.6 1 0 0 1 1 1 0 Lantibiotic streptin immunity protein COMPASS-Shg1 PF05205.7 EWC45228.1 - 1.7 8.9 11.2 3.8 7.8 1.7 3.4 1 1 3 4 4 4 0 COMPASS (Complex proteins associated with Set1p) component shg1 APH PF01636.18 EWC45229.1 - 1.6e-11 44.4 1.1 2.3e-11 43.8 0.8 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family THUMP PF02926.12 EWC45230.1 - 8.1e-20 71.1 1.4 1.2e-19 70.5 1.0 1.3 1 0 0 1 1 1 1 THUMP domain RINT1_TIP1 PF04437.8 EWC45231.1 - 6.1e-123 410.9 0.0 6.1e-123 410.9 0.0 1.9 3 0 0 3 3 3 1 RINT-1 / TIP-1 family ATP-synt_ab PF00006.20 EWC45231.1 - 0.0027 17.2 0.2 0.0054 16.2 0.2 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain Cep57_CLD PF14073.1 EWC45231.1 - 0.24 11.2 9.0 0.37 10.5 2.8 2.4 2 0 0 2 2 2 0 Centrosome localisation domain of Cep57 Snapin_Pallidin PF14712.1 EWC45231.1 - 4.7 7.5 10.1 1 9.7 2.9 2.8 2 0 0 2 2 2 0 Snapin/Pallidin ABC_tran PF00005.22 EWC45232.1 - 7.2e-30 104.0 0.1 1.3e-29 103.2 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ABC2_membrane PF01061.19 EWC45232.1 - 9.4e-28 96.8 30.9 1.4e-27 96.2 21.4 1.2 1 0 0 1 1 1 1 ABC-2 type transporter AAA_21 PF13304.1 EWC45232.1 - 1.6e-09 38.2 1.4 1.7e-07 31.5 0.1 3.0 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.1 EWC45232.1 - 1.3e-06 28.5 0.1 2.2e-06 27.7 0.1 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_17 PF13207.1 EWC45232.1 - 1.1e-05 26.2 0.0 2.3e-05 25.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 EWC45232.1 - 1.6e-05 24.7 0.0 2.8e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.1 EWC45232.1 - 7.3e-05 22.2 0.0 0.00077 18.9 0.0 2.2 2 0 0 2 2 2 1 AAA domain DUF258 PF03193.11 EWC45232.1 - 0.0001 21.5 0.1 0.00019 20.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Zeta_toxin PF06414.7 EWC45232.1 - 0.00011 21.3 0.0 0.00018 20.6 0.0 1.2 1 0 0 1 1 1 1 Zeta toxin AAA_22 PF13401.1 EWC45232.1 - 0.00031 20.8 0.0 0.00076 19.6 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 EWC45232.1 - 0.00051 20.3 0.0 0.00099 19.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.1 EWC45232.1 - 0.0017 17.8 0.1 0.0037 16.7 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain T2SE PF00437.15 EWC45232.1 - 0.0024 16.8 0.0 0.0039 16.1 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_15 PF13175.1 EWC45232.1 - 0.0038 16.3 0.3 0.7 8.8 0.0 2.4 3 0 0 3 3 3 1 AAA ATPase domain AAA_28 PF13521.1 EWC45232.1 - 0.0046 16.9 0.0 0.0076 16.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain UPF0079 PF02367.12 EWC45232.1 - 0.0076 15.8 0.0 0.014 15.0 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised P-loop hydrolase UPF0079 AAA PF00004.24 EWC45232.1 - 0.0085 16.2 0.0 0.035 14.3 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_13 PF13166.1 EWC45232.1 - 0.01 14.3 0.8 0.29 9.5 0.1 2.2 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.1 EWC45232.1 - 0.011 15.4 0.0 0.024 14.3 0.0 1.5 1 0 0 1 1 1 0 Part of AAA domain AAA_5 PF07728.9 EWC45232.1 - 0.014 15.1 0.0 0.028 14.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) SMC_N PF02463.14 EWC45232.1 - 0.014 14.6 0.0 0.18 11.0 0.0 2.1 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain NACHT PF05729.7 EWC45232.1 - 0.017 14.8 0.0 0.035 13.7 0.0 1.6 1 0 0 1 1 1 0 NACHT domain AAA_14 PF13173.1 EWC45232.1 - 0.019 14.8 0.0 0.046 13.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 EWC45232.1 - 0.026 14.6 0.4 0.078 13.1 0.0 2.0 3 0 0 3 3 1 0 RNA helicase cobW PF02492.14 EWC45232.1 - 0.029 13.8 0.1 0.049 13.0 0.1 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain KAP_NTPase PF07693.9 EWC45232.1 - 0.032 13.2 0.0 0.04 12.9 0.0 1.3 1 0 0 1 1 1 0 KAP family P-loop domain Arch_ATPase PF01637.13 EWC45232.1 - 0.034 13.8 0.0 0.058 13.0 0.0 1.3 1 0 0 1 1 1 0 Archaeal ATPase MobB PF03205.9 EWC45232.1 - 0.044 13.4 0.0 0.078 12.6 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_10 PF12846.2 EWC45232.1 - 0.064 12.6 0.1 0.13 11.6 0.1 1.4 1 0 0 1 1 1 0 AAA-like domain SRP54 PF00448.17 EWC45232.1 - 0.065 12.6 0.0 0.16 11.3 0.0 1.6 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain MMR_HSR1 PF01926.18 EWC45232.1 - 0.089 12.7 0.0 0.2 11.6 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_30 PF13604.1 EWC45232.1 - 0.14 11.7 0.0 0.26 10.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain DNA_ligase_A_M PF01068.16 EWC45233.1 - 4.5e-47 160.0 1.1 6.6e-44 149.7 0.0 3.1 3 0 0 3 3 3 2 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.9 EWC45233.1 - 2.9e-40 137.9 0.1 6.1e-40 136.8 0.0 1.6 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.10 EWC45233.1 - 4.5e-21 75.0 0.0 5.2e-20 71.6 0.0 2.6 2 0 0 2 2 2 1 ATP dependent DNA ligase C terminal region DAD PF02109.11 EWC45234.1 - 1.8e-49 166.4 2.5 2.2e-49 166.2 1.7 1.0 1 0 0 1 1 1 1 DAD family DUF1180 PF06679.7 EWC45234.1 - 0.042 13.7 2.8 0.077 12.8 1.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) DUF2360 PF10152.4 EWC45235.1 - 5.9 7.1 7.6 3.9 7.7 2.1 2.1 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein (DUF2360) DUF3844 PF12955.2 EWC45236.1 - 1.2e-28 99.1 4.8 2e-28 98.4 3.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3844) Pro_isomerase PF00160.16 EWC45237.1 - 1e-46 158.9 1.0 1.1e-46 158.8 0.7 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD zf-RING_2 PF13639.1 EWC45238.1 - 4.4e-13 48.8 7.0 7.4e-13 48.1 4.9 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 EWC45238.1 - 6.9e-08 32.0 4.8 1.1e-07 31.3 3.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 EWC45238.1 - 8.3e-08 32.2 5.0 2e-07 31.0 3.4 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_5 PF14634.1 EWC45238.1 - 3.7e-06 26.5 4.6 5.8e-06 25.9 3.2 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 EWC45238.1 - 3.6e-05 23.7 6.3 5.8e-05 23.0 4.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 EWC45238.1 - 0.00014 21.4 3.0 0.00024 20.7 2.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 EWC45238.1 - 0.001 18.8 3.6 0.0021 17.8 2.5 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.1 EWC45238.1 - 0.064 12.8 6.5 0.099 12.2 4.5 1.3 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain PHD PF00628.24 EWC45238.1 - 0.2 11.3 5.7 0.35 10.5 3.9 1.4 1 0 0 1 1 1 0 PHD-finger zf-C3HC4_4 PF15227.1 EWC45238.1 - 0.23 11.3 5.1 0.54 10.1 3.5 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 EWC45238.1 - 0.36 10.5 3.1 0.86 9.3 2.1 1.7 1 0 0 1 1 1 0 RING-type zinc-finger FANCL_C PF11793.3 EWC45238.1 - 6.6 6.7 7.3 2.6 8.0 2.8 2.1 2 1 0 2 2 2 0 FANCL C-terminal domain Whi5 PF08528.6 EWC45239.1 - 2e-09 36.8 0.3 3.6e-09 36.0 0.2 1.4 1 0 0 1 1 1 1 Whi5 like SMN PF06003.7 EWC45239.1 - 1.1 8.2 7.6 2.6 7.0 5.3 1.5 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) tRNA-synt_2c PF01411.14 EWC45240.1 - 8.9e-208 691.0 0.0 1.3e-207 690.4 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.9 EWC45240.1 - 6.9e-15 54.6 1.0 1.6e-14 53.4 0.7 1.7 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DUF2935 PF11155.3 EWC45240.1 - 0.013 15.5 0.4 0.24 11.5 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF2935) 4HB_MCP_1 PF12729.2 EWC45240.1 - 0.31 10.3 6.4 4.1 6.7 0.1 2.6 2 0 0 2 2 2 0 Four helix bundle sensory module for signal transduction Aldedh PF00171.17 EWC45241.1 - 6.1e-144 479.8 0.1 7.1e-144 479.5 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.9 EWC45241.1 - 2.8e-07 29.5 0.0 4.2e-07 29.0 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA reductase (LuxC) RCR PF12273.3 EWC45243.1 - 1.8e-07 31.8 1.3 2.2e-07 31.4 0.9 1.1 1 0 0 1 1 1 1 Chitin synthesis regulation, resistance to Congo red DUF3752 PF12572.3 EWC45244.1 - 9.1e-37 126.5 11.6 9.1e-37 126.5 8.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF3752) Pkinase PF00069.20 EWC45245.1 - 4.1e-71 239.1 0.0 5.4e-71 238.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC45245.1 - 5.1e-36 124.0 0.1 7.9e-36 123.4 0.0 1.3 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 EWC45245.1 - 0.00016 20.7 0.0 0.00023 20.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like YrbL-PhoP_reg PF10707.4 EWC45245.1 - 0.029 13.7 0.0 0.063 12.6 0.0 1.5 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Kdo PF06293.9 EWC45245.1 - 0.038 13.0 0.0 0.065 12.2 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SCAN PF02023.12 EWC45245.1 - 0.13 11.7 0.4 0.33 10.4 0.0 1.9 2 0 0 2 2 2 0 SCAN domain UQ_con PF00179.21 EWC45246.1 - 9.3e-24 83.4 0.7 1.2e-23 83.0 0.5 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 EWC45246.1 - 1.3e-07 31.4 0.0 1.9e-07 30.9 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 EWC45246.1 - 9.7e-05 22.2 0.0 0.00014 21.7 0.0 1.2 1 0 0 1 1 1 1 RWD domain UEV PF05743.8 EWC45246.1 - 0.00037 20.1 0.0 0.00056 19.5 0.0 1.2 1 0 0 1 1 1 1 UEV domain UFC1 PF08694.6 EWC45246.1 - 0.086 12.3 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 RNA_pol_A_bac PF01000.21 EWC45247.1 - 9.4e-26 90.1 0.0 2e-25 89.0 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.19 EWC45247.1 - 5.6e-16 57.4 0.0 7.6e-16 56.9 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Complex1_49kDa PF00346.14 EWC45248.1 - 2.4e-107 358.0 0.0 3.4e-107 357.5 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit Peptidase_M1 PF01433.15 EWC45249.1 - 1.4e-07 30.9 0.0 1.4e-06 27.6 0.0 2.1 2 0 0 2 2 2 1 Peptidase family M1 HEAT PF02985.17 EWC45249.1 - 0.0087 16.0 0.1 0.26 11.4 0.0 2.9 2 0 0 2 2 2 1 HEAT repeat ThiF PF00899.16 EWC45250.1 - 9.7e-38 129.0 0.4 1.8e-37 128.1 0.3 1.4 1 0 0 1 1 1 1 ThiF family E2_bind PF08825.5 EWC45250.1 - 2.4e-30 104.1 0.9 4.2e-30 103.3 0.6 1.4 1 0 0 1 1 1 1 E2 binding domain UBACT PF02134.16 EWC45250.1 - 3.2e-24 84.2 0.2 5.9e-24 83.4 0.1 1.5 1 0 0 1 1 1 1 Repeat in ubiquitin-activating (UBA) protein UBA_e1_thiolCys PF10585.4 EWC45250.1 - 3.2e-15 55.2 2.7 3.2e-15 55.2 1.9 1.7 2 0 0 2 2 2 1 Ubiquitin-activating enzyme active site Shikimate_DH PF01488.15 EWC45250.1 - 0.00024 21.1 0.0 0.0005 20.1 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase MoeZ_MoeB PF05237.8 EWC45250.1 - 0.0019 17.7 0.4 0.0092 15.5 0.0 2.1 2 0 0 2 2 2 1 MoeZ/MoeB domain UAE_UbL PF14732.1 EWC45250.1 - 0.041 13.9 0.0 0.1 12.7 0.0 1.7 1 0 0 1 1 1 0 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain NAD_binding_7 PF13241.1 EWC45250.1 - 0.054 13.7 0.1 0.15 12.3 0.1 1.7 1 1 0 1 1 1 0 Putative NAD(P)-binding UBA_e1_C PF09358.5 EWC45250.1 - 0.093 12.8 0.0 0.16 12.1 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-activating enzyme e1 C-terminal domain TrkA_N PF02254.13 EWC45250.1 - 0.1 12.5 0.0 0.22 11.5 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain Pyr_redox PF00070.22 EWC45250.1 - 0.12 12.7 0.0 0.31 11.4 0.0 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Ecm33 PF12454.3 EWC45250.1 - 0.18 11.7 2.9 0.36 10.7 2.0 1.5 1 0 0 1 1 1 0 GPI-anchored cell wall organization protein Sec1 PF00995.18 EWC45251.1 - 1e-120 404.0 0.0 1.2e-120 403.8 0.0 1.0 1 0 0 1 1 1 1 Sec1 family FAD_binding_3 PF01494.14 EWC45252.1 - 6.9e-30 104.2 0.0 7.8e-29 100.8 0.0 2.1 1 1 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.7 EWC45252.1 - 2.6e-05 23.3 0.1 0.00054 18.9 0.0 2.7 3 0 0 3 3 3 1 Lycopene cyclase protein DAO PF01266.19 EWC45252.1 - 0.00056 18.9 0.0 0.0039 16.1 0.0 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 EWC45252.1 - 0.0019 18.1 0.0 0.003 17.4 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.9 EWC45252.1 - 0.0026 16.4 0.3 0.045 12.3 0.2 2.4 3 0 0 3 3 3 1 Tryptophan halogenase Thi4 PF01946.12 EWC45252.1 - 0.005 15.9 0.0 0.0077 15.3 0.0 1.2 1 0 0 1 1 1 1 Thi4 family NAD_binding_9 PF13454.1 EWC45252.1 - 0.0064 16.2 0.0 0.013 15.2 0.0 1.5 1 0 0 1 1 1 1 FAD-NAD(P)-binding Pyr_redox PF00070.22 EWC45252.1 - 0.026 14.8 0.2 0.07 13.5 0.1 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase SE PF08491.5 EWC45252.1 - 0.035 12.9 0.0 0.056 12.2 0.0 1.3 1 0 0 1 1 1 0 Squalene epoxidase HI0933_like PF03486.9 EWC45252.1 - 0.099 11.0 0.5 0.21 9.9 0.3 1.5 2 0 0 2 2 2 0 HI0933-like protein FAD_oxidored PF12831.2 EWC45252.1 - 0.25 10.3 1.8 0.48 9.4 1.3 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase Fungal_trans PF04082.13 EWC45253.1 - 4.5e-27 94.5 0.0 7.1e-27 93.9 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EWC45253.1 - 2.4e-05 24.1 9.8 4.3e-05 23.3 6.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Homoserine_dh PF00742.14 EWC45255.1 - 1.8e-50 171.1 0.0 2.5e-50 170.6 0.0 1.2 1 0 0 1 1 1 1 Homoserine dehydrogenase NAD_binding_3 PF03447.11 EWC45255.1 - 1.1e-14 54.7 0.0 2e-14 53.9 0.0 1.4 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain ThiF PF00899.16 EWC45255.1 - 0.088 12.6 0.1 0.16 11.8 0.1 1.4 1 0 0 1 1 1 0 ThiF family Amidase PF01425.16 EWC45256.1 - 4.3e-74 249.9 0.0 5.2e-74 249.6 0.0 1.1 1 0 0 1 1 1 1 Amidase Isochorismatase PF00857.15 EWC45256.1 - 2e-38 132.0 0.0 4e-38 131.0 0.0 1.5 1 0 0 1 1 1 1 Isochorismatase family Transp_cyt_pur PF02133.10 EWC45257.1 - 9.9e-77 258.3 34.0 1.1e-76 258.1 23.6 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin DUF2374 PF09574.5 EWC45257.1 - 3.3 7.3 7.8 0.46 10.1 1.4 2.6 2 0 0 2 2 2 0 Protein of unknown function (Duf2374) SAS4 PF15460.1 EWC45258.1 - 1.7e-05 24.6 0.3 1.7e-05 24.6 0.2 2.8 3 0 0 3 3 3 1 Something about silencing, SAS, complex subunit 4 Pacs-1 PF10254.4 EWC45258.1 - 0.22 10.1 7.1 0.46 9.0 4.9 1.5 1 0 0 1 1 1 0 PACS-1 cytosolic sorting protein zf-DHHC PF01529.15 EWC45260.1 - 2.4e-33 114.9 0.8 3e-33 114.6 0.0 1.6 2 0 0 2 2 2 1 DHHC palmitoyltransferase Chitin_synth_2 PF03142.10 EWC45261.1 - 2e-289 960.4 1.0 6.7e-289 958.6 0.1 1.8 2 0 0 2 2 2 1 Chitin synthase Glyco_trans_2_3 PF13632.1 EWC45261.1 - 6.4e-17 61.8 0.7 6.4e-17 61.8 0.5 2.1 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.1 EWC45261.1 - 7.6e-15 55.3 0.1 7e-14 52.1 0.0 2.1 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.1 EWC45261.1 - 1.7e-06 27.4 0.0 7.9e-05 22.0 0.0 2.2 2 0 0 2 2 2 1 Glycosyl transferase family 21 Cyt-b5 PF00173.23 EWC45261.1 - 1.1e-05 25.1 0.1 3.8e-05 23.3 0.0 2.0 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain Glycos_transf_2 PF00535.21 EWC45261.1 - 0.0044 16.7 0.0 0.017 14.7 0.0 2.0 3 0 0 3 3 3 1 Glycosyl transferase family 2 DUF456 PF04306.8 EWC45262.1 - 0.081 12.9 1.9 3.4 7.7 0.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF456) Sel1 PF08238.7 EWC45263.1 - 9.1e-26 89.7 34.2 0.00012 22.5 0.8 7.5 7 0 0 7 7 7 7 Sel1 repeat Cation_efflux PF01545.16 EWC45264.1 - 2.3e-82 276.2 0.7 5.8e-82 274.9 0.5 1.6 1 1 0 1 1 1 1 Cation efflux family Pkinase PF00069.20 EWC45265.1 - 1.4e-72 243.9 0.0 2.1e-72 243.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC45265.1 - 1.6e-38 132.2 0.0 2.5e-38 131.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase POLO_box PF00659.13 EWC45265.1 - 1.4e-15 56.9 0.3 6.3e-07 29.2 0.0 2.8 2 0 0 2 2 2 2 POLO box duplicated region Kinase-like PF14531.1 EWC45265.1 - 4.4e-09 35.7 0.0 2.5e-08 33.2 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.9 EWC45265.1 - 0.011 14.7 0.0 0.019 14.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family OPA3 PF07047.7 EWC45266.1 - 9.4e-35 119.3 2.4 3.2e-34 117.5 1.7 2.1 1 1 0 1 1 1 1 Optic atrophy 3 protein (OPA3) SCIMP PF15050.1 EWC45266.1 - 0.28 11.0 0.1 0.28 11.0 0.0 3.0 1 1 2 3 3 3 0 SCIMP protein FNIP_N PF14636.1 EWC45266.1 - 0.41 11.1 4.7 0.18 12.3 1.4 1.8 2 0 0 2 2 2 0 Folliculin-interacting protein N-terminus DHDPS PF00701.17 EWC45267.1 - 8.6e-37 126.2 0.0 1e-36 126.0 0.0 1.1 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family Myosin_head PF00063.16 EWC45268.1 - 1.4e-229 763.7 4.3 1.8e-229 763.3 3.0 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.8 EWC45268.1 - 4.9e-42 143.5 0.0 8.8e-42 142.6 0.0 1.5 1 0 0 1 1 1 1 Myosin tail SH3_1 PF00018.23 EWC45268.1 - 6.1e-14 51.1 0.2 1.2e-13 50.1 0.2 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 EWC45268.1 - 3.6e-10 39.2 0.0 9.4e-10 37.9 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 EWC45268.1 - 2.8e-09 36.3 0.2 9.2e-09 34.6 0.0 2.1 2 0 0 2 2 2 1 Variant SH3 domain AAA_22 PF13401.1 EWC45268.1 - 0.0036 17.4 0.1 0.012 15.7 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 EWC45268.1 - 0.024 15.4 0.1 0.12 13.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.7 EWC45268.1 - 0.037 13.1 0.0 0.078 12.0 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_18 PF13238.1 EWC45268.1 - 0.076 13.3 0.0 0.24 11.7 0.0 1.9 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 EWC45268.1 - 0.1 12.2 0.1 0.31 10.6 0.0 1.8 2 0 0 2 2 2 0 NACHT domain Hpr_kinase_C PF07475.7 EWC45268.1 - 0.27 10.5 1.5 7.3 5.8 0.0 2.7 3 0 0 3 3 3 0 HPr Serine kinase C-terminal domain IQ PF00612.22 EWC45268.1 - 1.4 8.7 15.2 0.48 10.2 0.7 3.0 3 0 0 3 3 2 0 IQ calmodulin-binding motif Asp PF00026.18 EWC45269.1 - 2.8e-05 23.5 0.1 0.00065 19.0 0.0 2.1 2 0 0 2 2 2 2 Eukaryotic aspartyl protease ATP-synt PF00231.14 EWC45270.1 - 3.2e-65 220.3 3.4 3.8e-65 220.1 2.3 1.0 1 0 0 1 1 1 1 ATP synthase DUF3549 PF12069.3 EWC45270.1 - 0.0071 15.1 0.1 0.01 14.6 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3549) Beta-Casp PF10996.3 EWC45270.1 - 0.053 13.4 0.1 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Beta-Casp domain Thg1C PF14413.1 EWC45270.1 - 0.062 12.9 0.1 0.15 11.7 0.0 1.5 1 0 0 1 1 1 0 Thg1 C terminal domain Topoisom_I_N PF02919.10 EWC45271.1 - 7.6e-93 309.7 4.6 7.6e-93 309.7 3.2 4.0 4 1 0 4 4 4 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topoisom_I PF01028.15 EWC45271.1 - 5e-82 274.5 8.7 5e-82 274.5 6.0 2.6 2 0 0 2 2 2 1 Eukaryotic DNA topoisomerase I, catalytic core Topo_C_assoc PF14370.1 EWC45271.1 - 7e-29 99.2 0.2 2.2e-28 97.7 0.2 1.9 1 0 0 1 1 1 1 C-terminal topoisomerase domain DNA_mis_repair PF01119.14 EWC45272.1 - 2.4e-09 36.6 0.0 4.2e-09 35.8 0.0 1.4 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.1 EWC45272.1 - 1.5e-07 31.1 0.0 3.6e-07 29.9 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 EWC45272.1 - 2.8e-07 30.2 0.0 8.8e-07 28.6 0.0 1.8 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Y_phosphatase2 PF03162.8 EWC45273.1 - 3.6e-44 150.0 0.0 3.1e-43 147.0 0.0 1.9 1 1 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.1 EWC45273.1 - 2.2e-07 31.3 0.2 3.2e-07 30.7 0.2 1.4 1 1 0 1 1 1 1 Tyrosine phosphatase family DUF3292 PF11696.3 EWC45273.1 - 0.011 13.6 0.1 0.013 13.3 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) DSPc PF00782.15 EWC45273.1 - 0.09 12.3 0.0 0.19 11.2 0.0 1.7 2 0 0 2 2 2 0 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 EWC45273.1 - 0.12 11.6 0.0 0.18 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Dynamitin PF04912.9 EWC45274.1 - 1.6e-34 119.3 14.6 7.9e-19 67.7 0.0 4.0 2 1 1 3 3 3 3 Dynamitin Fmp27_WPPW PF10359.4 EWC45274.1 - 0.0078 14.6 6.5 0.068 11.5 0.3 2.4 2 0 0 2 2 2 2 RNA pol II promoter Fmp27 protein domain Laminin_II PF06009.7 EWC45274.1 - 0.012 15.3 1.2 0.012 15.3 0.8 3.9 5 0 0 5 5 5 0 Laminin Domain II CorA PF01544.13 EWC45274.1 - 0.046 12.7 8.7 0.025 13.6 3.3 2.2 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein APG6 PF04111.7 EWC45274.1 - 0.3 10.1 14.8 0.51 9.3 0.6 2.5 2 0 0 2 2 2 0 Autophagy protein Apg6 AAA_23 PF13476.1 EWC45274.1 - 0.88 9.8 7.2 1.7 8.9 1.8 2.4 2 1 0 2 2 2 0 AAA domain IncA PF04156.9 EWC45274.1 - 1.2 8.6 19.5 2.9 7.4 4.5 3.2 3 0 0 3 3 3 0 IncA protein Spc7 PF08317.6 EWC45274.1 - 1.8 7.1 12.0 2.1 6.9 0.1 2.6 3 0 0 3 3 3 0 Spc7 kinetochore protein TerB-C PF15615.1 EWC45274.1 - 4 7.6 17.6 0.17 12.1 5.4 2.6 2 1 0 2 2 2 0 TerB-C domain WD40 PF00400.27 EWC45275.1 - 3.5e-06 26.6 0.1 0.00012 21.7 0.0 3.1 3 0 0 3 3 3 1 WD domain, G-beta repeat ENTH PF01417.15 EWC45276.1 - 6.8e-48 161.6 0.0 1e-47 161.1 0.0 1.3 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.11 EWC45276.1 - 0.0023 16.6 0.0 0.0041 15.8 0.0 1.4 1 0 0 1 1 1 1 ANTH domain DUF4264 PF14084.1 EWC45276.1 - 0.011 15.1 0.1 0.021 14.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4264) UIM PF02809.15 EWC45276.1 - 0.073 12.6 4.1 0.089 12.4 0.5 2.5 2 0 0 2 2 2 0 Ubiquitin interaction motif DUF1510 PF07423.6 EWC45276.1 - 0.35 10.2 13.1 3.2 7.0 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1510) Suc_Fer-like PF06999.7 EWC45277.1 - 1.3e-41 143.1 0.0 6.5e-34 117.9 0.0 2.1 2 0 0 2 2 2 2 Sucrase/ferredoxin-like AA_permease PF00324.16 EWC45278.1 - 4.9e-103 345.0 28.9 6.5e-103 344.6 20.0 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EWC45278.1 - 5.9e-33 114.0 32.5 6.3e-33 113.9 22.0 1.4 1 1 0 1 1 1 1 Amino acid permease DUF1992 PF09350.5 EWC45279.1 - 3.3e-20 71.6 0.2 9.2e-20 70.2 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1992) Med9 PF07544.8 EWC45279.1 - 0.062 13.0 0.3 0.2 11.4 0.2 1.9 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 SRP40_C PF05022.7 EWC45280.1 - 6.1e-28 97.1 1.8 1.4e-27 95.9 1.3 1.7 1 0 0 1 1 1 1 SRP40, C-terminal domain LisH PF08513.6 EWC45280.1 - 0.051 13.3 0.0 0.093 12.5 0.0 1.5 1 0 0 1 1 1 0 LisH FAM196 PF15265.1 EWC45280.1 - 1.6 7.8 36.9 2.1 7.4 25.6 1.3 1 0 0 1 1 1 0 FAM196 family Sec3_C PF09763.4 EWC45281.1 - 9.2e-160 533.1 11.2 1.4e-159 532.4 7.7 1.2 1 0 0 1 1 1 1 Exocyst complex component Sec3 Sec3-PIP2_bind PF15277.1 EWC45281.1 - 1.8e-28 98.2 0.0 4e-28 97.1 0.0 1.7 1 0 0 1 1 1 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH Vps52 PF04129.7 EWC45281.1 - 0.00055 18.5 1.6 0.0013 17.4 1.1 1.5 1 0 0 1 1 1 1 Vps52 / Sac2 family Sec3_C_2 PF15278.1 EWC45281.1 - 0.044 13.9 0.2 0.044 13.9 0.2 2.3 3 0 0 3 3 3 0 Sec3 exocyst complex subunit NTP_transferase PF00483.18 EWC45282.1 - 2.9e-47 161.0 0.0 4.9e-47 160.3 0.0 1.3 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.19 EWC45282.1 - 1.9e-16 58.7 17.4 4.8e-10 38.4 2.9 4.0 2 1 3 5 5 5 3 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.2 EWC45282.1 - 9.7e-11 41.9 0.0 1.4e-10 41.4 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep_2 PF14602.1 EWC45282.1 - 1.6e-07 30.7 3.0 1.6e-07 30.7 2.1 2.6 3 0 0 3 3 3 1 Hexapeptide repeat of succinyl-transferase Ribosomal_L7Ae PF01248.21 EWC45282.1 - 0.058 12.9 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family IspD PF01128.14 EWC45282.1 - 0.079 12.4 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase LRR_4 PF12799.2 EWC45283.1 - 5.2e-08 32.3 9.9 0.0024 17.4 0.1 4.4 4 2 1 5 5 5 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 EWC45283.1 - 3e-07 29.8 4.5 0.0021 17.9 0.0 6.0 6 0 0 6 6 6 1 Leucine Rich repeat LRR_1 PF00560.28 EWC45283.1 - 0.00083 19.0 8.2 2.8 8.2 0.0 6.8 7 0 0 7 7 7 1 Leucine Rich Repeat LRR_8 PF13855.1 EWC45283.1 - 0.026 14.2 11.8 0.052 13.3 0.7 4.6 2 2 3 5 5 5 0 Leucine rich repeat LRR_7 PF13504.1 EWC45283.1 - 2.7 8.5 16.8 38 5.1 0.0 7.3 9 0 0 9 9 9 0 Leucine rich repeat F-box PF00646.28 EWC45284.1 - 0.0037 16.8 0.0 0.0094 15.5 0.0 1.7 1 0 0 1 1 1 1 F-box domain V_ATPase_I PF01496.14 EWC45285.1 - 6.3e-284 943.6 2.7 7.1e-284 943.4 1.8 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family DUF972 PF06156.8 EWC45285.1 - 0.19 12.0 2.8 0.61 10.4 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF972) IncA PF04156.9 EWC45285.1 - 0.3 10.6 1.5 1.2 8.7 0.1 2.2 2 0 0 2 2 2 0 IncA protein DivIC PF04977.10 EWC45285.1 - 0.37 10.2 4.4 5.3 6.5 0.1 3.0 3 0 0 3 3 3 0 Septum formation initiator Med9 PF07544.8 EWC45285.1 - 0.4 10.4 2.0 6.7 6.5 0.1 2.6 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 PH_10 PF15411.1 EWC45286.1 - 9.2e-42 141.8 0.1 2e-41 140.7 0.1 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain RhoGEF PF00621.15 EWC45286.1 - 5.4e-35 120.8 0.2 1.4e-34 119.5 0.0 1.8 2 0 0 2 2 2 1 RhoGEF domain CDC24 PF06395.6 EWC45286.1 - 8.8e-18 64.1 0.1 1.9e-17 63.0 0.1 1.6 1 0 0 1 1 1 1 CDC24 Calponin PB1 PF00564.19 EWC45286.1 - 9.7e-14 50.8 0.0 2.5e-13 49.4 0.0 1.7 1 0 0 1 1 1 1 PB1 domain HsbA PF12296.3 EWC45286.1 - 0.0087 15.9 0.5 0.028 14.2 0.4 1.9 1 0 0 1 1 1 1 Hydrophobic surface binding protein A MCM_N PF14551.1 EWC45286.1 - 0.048 14.1 0.4 0.25 11.8 0.1 2.2 2 0 0 2 2 2 0 MCM N-terminal domain BRAP2 PF07576.7 EWC45287.1 - 2.1e-25 88.4 0.0 3.6e-25 87.6 0.0 1.4 1 0 0 1 1 1 1 BRCA1-associated protein 2 zf-UBP PF02148.14 EWC45287.1 - 1.1e-20 73.4 6.0 2.7e-20 72.2 4.2 1.6 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein zf-RING_2 PF13639.1 EWC45287.1 - 2.1e-10 40.2 10.2 2.1e-10 40.2 7.1 2.3 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.1 EWC45287.1 - 8.8e-07 28.5 8.1 8.8e-07 28.5 5.6 2.4 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 EWC45287.1 - 7.2e-05 22.3 6.3 7.2e-05 22.3 4.4 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EWC45287.1 - 8.6e-05 22.1 8.8 8.6e-05 22.1 6.1 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 EWC45287.1 - 0.0001 22.2 9.0 0.0001 22.2 6.2 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 EWC45287.1 - 0.00014 21.8 5.8 0.00014 21.8 4.0 1.9 2 0 0 2 2 1 1 RING-H2 zinc finger zf-Apc11 PF12861.2 EWC45287.1 - 0.00056 19.6 5.3 0.0012 18.5 3.7 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.1 EWC45287.1 - 0.0082 15.8 4.1 0.0082 15.8 2.8 3.0 2 1 0 2 2 2 1 RING-type zinc-finger THP2 PF09432.5 EWC45287.1 - 0.031 14.1 1.9 0.062 13.1 1.4 1.5 1 0 0 1 1 1 0 Tho complex subunit THP2 zf-RING_4 PF14570.1 EWC45287.1 - 0.081 12.5 7.3 0.19 11.3 5.1 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain DUF4200 PF13863.1 EWC45287.1 - 0.83 9.6 14.5 0.97 9.3 2.5 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) Prenyltrans PF00432.16 EWC45288.1 - 3.7e-35 119.1 28.5 7.9e-08 31.7 0.0 6.7 7 0 0 7 7 7 5 Prenyltransferase and squalene oxidase repeat Prenyltrans_2 PF13249.1 EWC45288.1 - 1.1e-24 87.0 0.0 4.7e-15 55.9 0.0 3.8 1 1 3 4 4 4 4 Prenyltransferase-like Prenyltrans_1 PF13243.1 EWC45288.1 - 6.5e-07 29.3 0.0 0.017 15.1 0.0 3.2 2 1 1 3 3 3 2 Prenyltransferase-like Hexapep PF00132.19 EWC45290.1 - 1.7e-10 39.8 10.0 5.3e-06 25.7 0.1 4.3 2 2 1 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.1 EWC45290.1 - 8.9e-08 31.5 12.3 0.0013 18.2 0.5 3.3 2 1 0 2 2 2 2 Hexapeptide repeat of succinyl-transferase PhoD PF09423.5 EWC45291.1 - 7.3e-60 202.8 0.0 1e-59 202.2 0.0 1.1 1 0 0 1 1 1 1 PhoD-like phosphatase fn3 PF00041.16 EWC45291.1 - 0.067 13.3 1.3 0.21 11.7 0.5 2.2 2 0 0 2 2 2 0 Fibronectin type III domain Acetyltransf_8 PF13523.1 EWC45292.1 - 3.8e-36 124.2 1.1 1.7e-34 118.8 0.7 2.1 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 EWC45292.1 - 4.1e-05 23.7 0.0 8.1e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 EWC45292.1 - 0.11 12.4 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Thiolase_N PF00108.18 EWC45293.1 - 9.7e-79 264.0 4.6 9.7e-79 264.0 3.2 1.8 3 0 0 3 3 3 1 Thiolase, N-terminal domain Thiolase_C PF02803.13 EWC45293.1 - 2.7e-45 152.7 0.3 2.7e-45 152.7 0.2 1.9 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.21 EWC45293.1 - 0.0097 15.4 2.2 0.068 12.6 0.5 2.5 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III_C PF08541.5 EWC45293.1 - 0.013 15.4 0.0 0.043 13.8 0.0 1.9 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ubiquitin PF00240.18 EWC45294.1 - 7.1e-205 662.8 35.8 1e-33 114.5 0.5 6.0 6 0 0 6 6 6 6 Ubiquitin family Rad60-SLD PF11976.3 EWC45294.1 - 3.7e-115 375.7 35.3 1.1e-18 66.6 0.5 6.0 6 0 0 6 6 6 6 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 EWC45294.1 - 5.5e-35 119.4 17.8 0.00032 20.8 0.1 8.0 6 6 0 6 6 6 6 Ubiquitin-like domain Telomere_Sde2 PF13019.1 EWC45294.1 - 7e-31 107.1 3.0 0.0023 17.6 0.0 6.0 6 0 0 6 6 6 6 Telomere stability and silencing DUF2407 PF10302.4 EWC45294.1 - 2.5e-19 69.2 5.8 0.29 11.3 0.0 6.2 1 1 3 6 6 6 6 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.1 EWC45294.1 - 3.8e-19 68.6 9.6 0.22 11.4 0.0 7.0 6 0 0 6 6 6 6 Ubiquitin-2 like Rad60 SUMO-like DUF2870 PF11069.3 EWC45294.1 - 8.3e-16 57.8 0.0 2.6 8.1 0.0 6.8 6 0 0 6 6 6 6 Protein of unknown function (DUF2870) FlgD_ig PF13860.1 EWC45294.1 - 7.7e-10 38.3 11.1 5.9 6.7 0.0 6.3 6 0 0 6 6 6 6 FlgD Ig-like domain TUG-UBL1 PF11470.3 EWC45294.1 - 7.5e-08 32.1 11.1 12 5.9 0.0 6.2 6 0 0 6 6 6 0 GLUT4 regulating protein TUG ACT_4 PF13291.1 EWC45294.1 - 1.4e-05 25.3 2.3 1.2e+02 3.0 0.0 6.1 6 0 0 6 6 6 0 ACT domain Big_3_3 PF13750.1 EWC45294.1 - 2.9e-05 23.5 0.0 87 2.5 0.0 5.7 6 0 0 6 6 6 0 Bacterial Ig-like domain (group 3) Plexin_cytopl PF08337.7 EWC45294.1 - 0.0049 15.2 23.6 7 4.8 0.1 7.7 7 5 0 7 7 7 5 Plexin cytoplasmic RasGAP domain Tash_PEST PF07708.6 EWC45294.1 - 0.03 14.2 47.6 5.5 7.0 1.2 6.3 6 0 0 6 6 6 0 Tash protein PEST motif GABP-alpha PF11620.3 EWC45294.1 - 0.14 12.1 14.6 99 3.0 0.1 5.8 6 0 0 6 6 6 0 GA-binding protein alpha chain FBPase PF00316.15 EWC45295.1 - 1.8e-122 408.2 0.0 2.1e-122 408.0 0.0 1.0 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase Inositol_P PF00459.20 EWC45295.1 - 0.031 13.5 0.0 0.079 12.2 0.0 1.6 2 0 0 2 2 2 0 Inositol monophosphatase family Coatamer_beta_C PF07718.7 EWC45296.1 - 0.049 13.2 0.1 0.085 12.5 0.0 1.4 1 0 0 1 1 1 0 Coatomer beta C-terminal region DUF4098 PF13345.1 EWC45297.1 - 0.0013 18.6 22.0 0.3 11.0 0.9 6.3 7 2 1 8 8 8 4 Domain of unknown function (DUF4098) DUF3237 PF11578.3 EWC45297.1 - 0.09 12.0 0.1 0.32 10.2 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3237) Ribosomal_S7e PF01251.13 EWC45298.1 - 7.8e-83 276.6 0.4 8.6e-83 276.4 0.3 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e Kri1_C PF12936.2 EWC45300.1 - 1.5e-22 79.3 0.7 1.5e-22 79.3 0.5 4.4 4 1 0 4 4 4 1 KRI1-like family C-terminal Kri1 PF05178.7 EWC45300.1 - 1.4e-14 54.1 28.3 1.4e-14 54.1 19.6 5.6 4 2 1 5 5 5 1 KRI1-like family Yippee-Mis18 PF03226.9 EWC45301.1 - 6.8e-23 80.5 0.3 7.7e-23 80.3 0.2 1.1 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly HNH_5 PF14279.1 EWC45301.1 - 0.0052 16.7 1.2 0.34 10.9 0.1 2.2 1 1 1 2 2 2 2 HNH endonuclease DUF3268 PF11672.3 EWC45301.1 - 0.049 13.7 0.7 0.29 11.2 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3268) RIG-I_C-RD PF11648.3 EWC45301.1 - 0.12 12.2 1.8 0.23 11.3 1.2 1.5 1 1 0 1 1 1 0 C-terminal domain of RIG-I Endonuclease_7 PF02945.10 EWC45301.1 - 0.17 11.6 3.2 0.97 9.1 2.2 1.9 1 1 0 1 1 1 0 Recombination endonuclease VII CENP-Q PF13094.1 EWC45302.1 - 5.7e-05 23.1 6.9 5.7e-05 23.1 4.8 2.0 2 0 0 2 2 2 1 CENP-Q, a CENPA-CAD centromere complex subunit Tropomyosin PF00261.15 EWC45302.1 - 0.014 14.5 7.1 0.014 14.5 4.9 2.1 2 1 1 3 3 3 0 Tropomyosin HDV_ag PF01517.13 EWC45302.1 - 0.049 13.3 0.2 0.049 13.3 0.1 2.1 1 1 1 2 2 2 0 Hepatitis delta virus delta antigen PAT1 PF09770.4 EWC45302.1 - 0.5 8.5 11.4 0.7 8.0 7.9 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Pup PF05639.6 EWC45302.1 - 2.3 8.7 9.4 1.1 9.7 1.8 2.7 2 0 0 2 2 2 0 Pup-like protein Sen15 PF09631.5 EWC45303.1 - 1.1e-24 86.5 0.0 1.4e-24 86.2 0.0 1.1 1 0 0 1 1 1 1 Sen15 protein WWbp PF10349.4 EWC45303.1 - 0.069 14.0 0.4 0.093 13.6 0.2 1.2 1 0 0 1 1 1 0 WW-domain ligand protein DUF2985 PF11204.3 EWC45304.1 - 4.9e-37 125.5 1.8 4.9e-37 125.5 1.2 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2985) CobS PF02654.10 EWC45305.1 - 0.44 10.0 5.1 0.038 13.5 0.6 1.4 2 0 0 2 2 2 0 Cobalamin-5-phosphate synthase adh_short PF00106.20 EWC45308.1 - 1.7e-17 63.8 0.0 2.7e-17 63.1 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EWC45308.1 - 8.5e-07 28.9 0.0 1.5e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EWC45308.1 - 8.9e-07 28.7 0.0 1.3e-06 28.2 0.0 1.2 1 0 0 1 1 1 1 KR domain THF_DHG_CYH_C PF02882.14 EWC45308.1 - 5.2e-05 22.3 0.1 0.0001 21.4 0.1 1.4 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DUF4096 PF13340.1 EWC45308.1 - 0.0092 15.8 0.1 3.1 7.7 0.0 3.0 3 0 0 3 3 3 1 Putative transposase of IS4/5 family (DUF4096) CDO_I PF05995.7 EWC45308.1 - 0.087 11.9 0.0 0.13 11.4 0.0 1.3 1 0 0 1 1 1 0 Cysteine dioxygenase type I E1-E2_ATPase PF00122.15 EWC45309.1 - 1.3e-57 194.4 4.3 3.3e-57 193.1 3.0 1.7 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 EWC45309.1 - 2.2e-46 157.6 11.5 2.2e-46 157.6 8.0 1.9 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 EWC45309.1 - 1.4e-29 104.0 0.0 5.6e-29 102.1 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 EWC45309.1 - 8.3e-20 70.5 0.0 1.7e-19 69.5 0.0 1.5 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 EWC45309.1 - 9.8e-14 51.9 0.0 2.2e-13 50.8 0.0 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 EWC45309.1 - 2.6e-08 33.2 0.0 2.9e-07 29.8 0.0 2.5 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.7 EWC45309.1 - 2.8e-06 27.1 0.3 0.00053 19.6 0.2 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase BLVR PF06375.6 EWC45309.1 - 0.16 11.7 0.0 0.36 10.6 0.0 1.5 1 0 0 1 1 1 0 Bovine leukaemia virus receptor (BLVR) Mit_KHE1 PF10173.4 EWC45311.1 - 0.13 12.1 0.2 0.18 11.6 0.2 1.2 1 0 0 1 1 1 0 Mitochondrial K+-H+ exchange-related PAT1 PF09770.4 EWC45312.1 - 8.7 4.4 14.8 11 4.0 10.3 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 bZIP_1 PF00170.16 EWC45314.1 - 0.00018 21.4 32.1 0.032 14.1 2.8 5.6 3 1 2 5 5 5 3 bZIP transcription factor DUF904 PF06005.7 EWC45314.1 - 0.00043 20.5 39.2 0.29 11.4 0.0 4.7 3 2 1 4 4 4 2 Protein of unknown function (DUF904) DivIC PF04977.10 EWC45314.1 - 0.0064 15.9 4.5 0.0064 15.9 3.2 4.9 1 1 4 5 5 5 2 Septum formation initiator ATG16 PF08614.6 EWC45314.1 - 0.045 13.5 29.7 0.14 11.9 11.3 2.7 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF972 PF06156.8 EWC45314.1 - 0.16 12.3 28.3 0.25 11.6 0.2 4.4 1 1 3 4 4 4 0 Protein of unknown function (DUF972) CCDC155 PF14662.1 EWC45314.1 - 0.16 11.5 35.1 0.11 12.0 20.1 2.7 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 APG6 PF04111.7 EWC45314.1 - 0.23 10.4 37.9 0.18 10.8 13.0 2.6 1 1 1 2 2 2 0 Autophagy protein Apg6 FlaC_arch PF05377.6 EWC45314.1 - 0.28 11.1 8.5 36 4.3 0.2 4.3 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) Reo_sigmaC PF04582.7 EWC45314.1 - 0.29 10.2 1.8 1.4 7.9 0.1 2.1 1 1 1 2 2 2 0 Reovirus sigma C capsid protein TSC22 PF01166.13 EWC45314.1 - 0.38 10.7 0.1 0.38 10.7 0.1 4.8 3 1 2 5 5 4 0 TSC-22/dip/bun family CALCOCO1 PF07888.6 EWC45314.1 - 0.61 8.3 27.5 1.1 7.4 18.5 1.8 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like GAS PF13851.1 EWC45314.1 - 1.3 8.2 36.7 13 4.9 21.0 3.8 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding CENP-F_leu_zip PF10473.4 EWC45314.1 - 1.6 8.6 42.2 2.5 7.9 10.7 3.6 3 1 1 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 HOOK PF05622.7 EWC45314.1 - 2.5 5.7 36.6 0.16 9.7 12.1 2.6 1 1 0 1 1 1 0 HOOK protein DUF4201 PF13870.1 EWC45314.1 - 3 7.2 36.3 0.065 12.6 3.6 4.0 2 1 2 4 4 4 0 Domain of unknown function (DUF4201) Nup54 PF13874.1 EWC45314.1 - 4.7 6.8 17.1 8 6.1 0.0 3.9 2 1 0 3 3 3 0 Nucleoporin complex subunit 54 Pectate_lyase_3 PF12708.2 EWC45316.1 - 4.8e-78 262.3 4.1 5.8e-61 206.4 0.7 2.3 2 0 0 2 2 2 2 Pectate lyase superfamily protein End_N_terminal PF12218.3 EWC45316.1 - 3.3e-05 23.2 1.9 0.039 13.4 0.2 2.9 2 0 0 2 2 2 2 N terminal extension of bacteriophage endosialidase Beta_helix PF13229.1 EWC45316.1 - 0.038 13.7 0.4 0.16 11.7 0.1 2.1 1 1 0 1 1 1 0 Right handed beta helix region LCCL PF03815.14 EWC45317.1 - 6.2e-17 61.3 0.0 9.9e-17 60.7 0.0 1.3 1 0 0 1 1 1 1 LCCL domain Tox-HNH-EHHH PF15657.1 EWC45317.1 - 0.12 12.5 2.7 0.24 11.5 1.9 1.4 1 0 0 1 1 1 0 HNH/Endo VII superfamily nuclease toxins Sugar_tr PF00083.19 EWC45318.1 - 6.8e-82 275.4 10.7 9e-82 275.0 7.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EWC45318.1 - 4.1e-24 84.9 28.1 6.1e-24 84.3 19.5 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Glyco_hydro_31 PF01055.21 EWC45319.1 - 4.4e-144 480.5 1.1 5.7e-144 480.2 0.8 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.1 EWC45319.1 - 1.6e-08 34.2 0.1 3.6e-08 33.1 0.1 1.6 1 0 0 1 1 1 1 Galactose mutarotase-like Init_tRNA_PT PF04179.7 EWC45319.1 - 0.058 12.2 0.0 0.091 11.6 0.0 1.2 1 0 0 1 1 1 0 Initiator tRNA phosphoribosyl transferase PLC-beta_C PF08703.5 EWC45320.1 - 0.061 13.0 1.1 0.68 9.6 0.3 2.1 2 0 0 2 2 2 0 PLC-beta C terminal ERp29 PF07749.7 EWC45320.1 - 0.096 13.3 0.8 3.1 8.4 0.1 2.6 2 0 0 2 2 2 0 Endoplasmic reticulum protein ERp29, C-terminal domain HAUS-augmin3 PF14932.1 EWC45320.1 - 0.11 11.6 1.2 12 5.0 0.0 2.4 3 0 0 3 3 3 0 HAUS augmin-like complex subunit 3 DUF148 PF02520.12 EWC45320.1 - 0.13 12.0 0.3 0.24 11.2 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function DUF148 DUF1664 PF07889.7 EWC45320.1 - 0.41 10.4 2.4 1 9.1 0.3 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) GAT PF03127.9 EWC45320.1 - 0.49 10.4 2.9 1.2 9.1 0.0 2.6 3 1 0 3 3 3 0 GAT domain AAA_12 PF13087.1 EWC45321.1 - 4.7e-21 75.0 0.2 9.2e-21 74.1 0.2 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 EWC45321.1 - 3.5e-20 72.5 0.0 7.4e-20 71.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 EWC45321.1 - 1.4e-05 24.7 0.0 5.1e-05 22.9 0.0 1.9 1 0 0 1 1 1 1 Part of AAA domain AAA_30 PF13604.1 EWC45321.1 - 0.01 15.4 0.0 0.37 10.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain UvrD_C_2 PF13538.1 EWC45321.1 - 0.017 15.2 0.0 0.068 13.3 0.0 2.0 2 0 0 2 2 2 0 UvrD-like helicase C-terminal domain RRM_5 PF13893.1 EWC45321.1 - 0.023 14.5 0.0 0.075 12.8 0.0 1.9 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PhoH PF02562.11 EWC45321.1 - 0.027 13.7 0.0 0.055 12.7 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein Peptidase_M10 PF00413.19 EWC45323.1 - 4.9e-12 45.8 0.1 7.6e-12 45.2 0.1 1.3 1 0 0 1 1 1 1 Matrixin Metallopep PF12044.3 EWC45323.1 - 1.1e-06 27.4 0.2 1.5e-06 26.9 0.1 1.2 1 0 0 1 1 1 1 Putative peptidase family Reprolysin_5 PF13688.1 EWC45323.1 - 8.1e-06 25.8 0.0 9.7e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.1 EWC45323.1 - 2.3e-05 24.9 0.0 3.3e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.1 EWC45323.1 - 3.2e-05 24.0 0.0 3.8e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.1 EWC45323.1 - 0.0001 21.9 0.0 0.00012 21.6 0.0 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M66 PF10462.4 EWC45323.1 - 0.0001 21.2 0.3 0.00014 20.8 0.2 1.2 1 0 0 1 1 1 1 Peptidase M66 Peptidase_M43 PF05572.8 EWC45323.1 - 0.0023 17.5 0.1 0.0031 17.1 0.1 1.2 1 0 0 1 1 1 1 Pregnancy-associated plasma protein-A Peptidase_M54 PF07998.6 EWC45323.1 - 0.0035 17.1 0.0 0.006 16.3 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M54 Na_H_Exchanger PF00999.16 EWC45325.1 - 3.7e-67 226.5 17.5 4.3e-67 226.2 12.1 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Nha1_C PF08619.5 EWC45325.1 - 1.7e-39 136.3 27.6 6.2e-31 108.1 6.4 3.1 1 1 2 3 3 3 3 Alkali metal cation/H+ antiporter Nha1 C terminus DUF21 PF01595.15 EWC45325.1 - 0.0027 17.0 1.5 0.0077 15.5 1.1 1.7 1 0 0 1 1 1 1 Domain of unknown function DUF21 Ras PF00071.17 EWC45326.1 - 8.9e-33 112.9 0.6 1.4e-32 112.2 0.4 1.3 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EWC45326.1 - 8.3e-22 77.9 0.2 7e-21 74.9 0.0 2.1 2 0 0 2 2 2 1 Miro-like protein Arf PF00025.16 EWC45326.1 - 2.3e-07 30.2 0.1 3.1e-07 29.7 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 EWC45326.1 - 3.4e-06 26.3 0.6 4.6e-06 25.9 0.4 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region DLIC PF05783.6 EWC45326.1 - 0.011 14.4 0.3 0.93 8.0 0.0 2.2 2 0 0 2 2 2 0 Dynein light intermediate chain (DLIC) MMR_HSR1 PF01926.18 EWC45326.1 - 0.035 14.0 0.0 0.087 12.7 0.0 1.6 1 1 0 1 1 1 0 50S ribosome-binding GTPase G-alpha PF00503.15 EWC45326.1 - 0.12 10.9 3.0 0.14 10.8 0.0 2.2 1 1 2 3 3 3 0 G-protein alpha subunit EnY2 PF10163.4 EWC45327.1 - 1.2e-08 34.8 0.4 2.6e-08 33.6 0.3 1.5 1 1 0 1 1 1 1 Transcription factor e(y)2 DUF3366 PF11846.3 EWC45327.1 - 0.066 13.0 1.0 0.091 12.6 0.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3366) WD40 PF00400.27 EWC45328.1 - 1.2e-23 82.0 8.0 5.2e-10 38.8 0.0 4.2 4 0 0 4 4 4 3 WD domain, G-beta repeat CAF1C_H4-bd PF12265.3 EWC45328.1 - 2.5e-19 68.9 0.0 9.6e-19 67.0 0.0 2.0 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex Apc4_WD40 PF12894.2 EWC45328.1 - 0.027 13.9 0.0 3.4 7.2 0.0 3.3 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain PalH PF08733.5 EWC45329.1 - 7.5e-86 288.0 2.0 1.1e-85 287.5 1.4 1.2 1 0 0 1 1 1 1 PalH/RIM21 Fungal_trans PF04082.13 EWC45330.1 - 4.6e-21 74.8 0.1 9.5e-21 73.8 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.21 EWC45330.1 - 4.4e-09 36.1 13.5 0.00034 20.7 2.8 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 EWC45330.1 - 3.7e-07 30.0 16.3 2.8e-06 27.3 4.8 3.0 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.1 EWC45330.1 - 0.00034 20.7 19.8 0.0014 18.7 2.6 3.2 3 0 0 3 3 3 2 C2H2-type zinc finger PLAC8 PF04749.12 EWC45331.1 - 4.3e-21 75.4 14.1 6.1e-21 74.9 9.8 1.2 1 0 0 1 1 1 1 PLAC8 family HSP70 PF00012.15 EWC45332.1 - 2e-12 45.8 0.1 1.3e-10 39.8 0.0 2.1 2 0 0 2 2 2 2 Hsp70 protein DUF1180 PF06679.7 EWC45333.1 - 0.14 12.0 0.6 0.3 10.9 0.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) TRAM_LAG1_CLN8 PF03798.11 EWC45335.1 - 5.1e-32 111.0 22.4 5.1e-32 111.0 15.5 1.9 2 0 0 2 2 2 1 TLC domain TRAM1 PF08390.6 EWC45335.1 - 2.6e-17 62.0 0.1 5.7e-17 60.9 0.1 1.6 1 0 0 1 1 1 1 TRAM1-like protein MCM PF00493.18 EWC45337.1 - 9e-138 458.5 0.7 1.3e-137 458.0 0.5 1.2 1 0 0 1 1 1 1 MCM2/3/5 family MCM_N PF14551.1 EWC45337.1 - 9.8e-19 68.0 1.1 4.9e-18 65.7 0.0 2.6 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.16 EWC45337.1 - 2e-07 30.4 0.0 2.3e-06 26.9 0.0 2.3 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.21 EWC45337.1 - 0.0011 18.5 0.0 0.0023 17.4 0.0 1.5 1 0 0 1 1 1 1 Sigma-54 interaction domain DUF834 PF05754.9 EWC45337.1 - 0.0038 16.9 5.6 0.013 15.2 3.9 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF834) AAA_5 PF07728.9 EWC45337.1 - 0.0044 16.7 0.0 0.016 14.9 0.0 2.0 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.6 EWC45337.1 - 0.0075 15.8 0.0 0.016 14.8 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DUF2360 PF10152.4 EWC45337.1 - 0.074 13.3 2.3 0.11 12.7 0.2 2.4 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein (DUF2360) DUF4011 PF13195.1 EWC45337.1 - 0.34 10.9 2.7 0.4 10.6 0.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4011) Rpp20 PF12328.3 EWC45339.1 - 2.1e-29 102.0 9.0 5.9e-29 100.5 6.2 1.6 1 1 0 1 1 1 1 Rpp20 subunit of nuclear RNase MRP and P Alba PF01918.16 EWC45339.1 - 1.9e-16 59.3 0.4 3.4e-16 58.5 0.3 1.4 1 0 0 1 1 1 1 Alba zf-C3HC4_2 PF13923.1 EWC45340.1 - 1.5e-09 37.7 10.6 1.5e-09 37.7 7.4 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EWC45340.1 - 9.6e-09 34.7 13.3 1.2e-08 34.4 6.8 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EWC45340.1 - 2.4e-08 33.5 13.8 5.9e-08 32.3 6.8 2.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 EWC45340.1 - 3.9e-08 32.8 7.0 3.9e-08 32.8 4.9 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EWC45340.1 - 4.7e-08 32.7 9.6 4.7e-08 32.7 6.7 2.2 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_4 PF15227.1 EWC45340.1 - 2.1e-06 27.4 9.6 2.1e-06 27.4 6.6 2.3 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING U-box PF04564.10 EWC45340.1 - 2.8e-05 24.0 0.0 0.00011 22.0 0.0 2.0 2 0 0 2 2 2 1 U-box domain zf-RING_UBOX PF13445.1 EWC45340.1 - 8.9e-05 22.1 7.3 8.9e-05 22.1 5.0 2.2 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_6 PF14835.1 EWC45340.1 - 0.00066 19.4 2.4 0.00066 19.4 1.6 2.3 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-rbx1 PF12678.2 EWC45340.1 - 0.0018 18.3 6.1 0.0018 18.3 4.2 2.2 2 1 0 2 2 2 1 RING-H2 zinc finger zf-RING_4 PF14570.1 EWC45340.1 - 0.0065 16.0 2.7 0.0065 16.0 1.9 2.5 3 0 0 3 3 3 1 RING/Ubox like zinc-binding domain zf-Nse PF11789.3 EWC45340.1 - 1.3 8.6 7.6 0.19 11.2 2.3 1.8 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit zf-P11 PF03854.9 EWC45340.1 - 6 6.4 8.9 1.9 8.0 2.8 2.2 2 0 0 2 2 2 0 P-11 zinc finger Snf7 PF03357.16 EWC45341.1 - 5.1e-19 68.2 23.2 8.5e-19 67.5 16.1 1.4 1 0 0 1 1 1 1 Snf7 UPF0184 PF03670.8 EWC45341.1 - 0.18 11.9 2.8 1.4 9.1 0.2 2.7 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0184) GSDH PF07995.6 EWC45342.1 - 0.051 12.6 0.6 0.063 12.3 0.4 1.1 1 0 0 1 1 1 0 Glucose / Sorbosone dehydrogenase TRAPPC-Trs85 PF12739.2 EWC45343.1 - 3.5e-106 355.3 0.5 8.2e-106 354.1 0.2 1.6 2 0 0 2 2 2 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit DUF3146 PF11344.3 EWC45343.1 - 0.14 11.6 0.0 0.31 10.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3146) Utp8 PF10395.4 EWC45343.1 - 0.18 10.0 0.0 0.27 9.4 0.0 1.1 1 0 0 1 1 1 0 Utp8 family PolyA_pol PF01743.15 EWC45345.1 - 3e-15 56.5 0.0 5.7e-15 55.6 0.0 1.5 1 0 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.2 EWC45345.1 - 0.00055 19.4 0.0 0.0014 18.1 0.0 1.7 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A PPR_2 PF13041.1 EWC45346.1 - 9.6e-42 140.7 12.9 7.5e-11 41.8 0.0 11.5 11 1 1 12 12 12 10 PPR repeat family PPR_3 PF13812.1 EWC45346.1 - 9.6e-23 78.5 13.4 0.0056 16.8 0.0 13.6 15 0 0 15 15 15 6 Pentatricopeptide repeat domain PPR PF01535.15 EWC45346.1 - 2.2e-19 67.9 23.1 0.00042 20.1 0.0 12.8 16 1 0 16 16 16 5 PPR repeat PPR_1 PF12854.2 EWC45346.1 - 2.1e-16 59.0 1.6 4.4e-06 26.0 0.0 7.5 8 0 0 8 8 8 4 PPR repeat TPR_16 PF13432.1 EWC45346.1 - 1.2e-06 28.9 7.1 0.031 14.9 0.1 6.1 5 1 0 5 5 5 2 Tetratricopeptide repeat RPM2 PF08579.6 EWC45346.1 - 1.6e-06 28.2 0.1 0.0021 18.1 0.0 2.9 2 0 0 2 2 2 2 Mitochondrial ribonuclease P subunit (RPM2) DUF2454 PF10521.4 EWC45348.1 - 2.5e-34 118.5 0.0 3.3e-34 118.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2454) TRI5 PF06330.6 EWC45348.1 - 0.043 12.4 0.0 0.081 11.5 0.0 1.3 1 0 0 1 1 1 0 Trichodiene synthase (TRI5) DUF1237 PF06824.6 EWC45349.1 - 6.1e-171 568.7 0.0 7.1e-171 568.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1237) DnaJ PF00226.26 EWC45350.1 - 2.1e-15 56.2 0.0 3.6e-15 55.4 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain FAD_binding_3 PF01494.14 EWC45351.1 - 2e-17 63.2 0.6 5e-09 35.6 0.1 3.1 2 1 0 2 2 2 2 FAD binding domain DAO PF01266.19 EWC45351.1 - 6.7e-07 28.5 0.1 7.2e-06 25.1 0.0 2.0 1 1 1 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 EWC45351.1 - 6.2e-05 22.0 0.0 0.00011 21.1 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.9 EWC45351.1 - 0.00047 18.7 0.0 0.00065 18.2 0.0 1.2 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox PF00070.22 EWC45351.1 - 0.0027 18.0 0.0 0.0051 17.1 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 EWC45351.1 - 0.0038 17.2 0.0 0.0082 16.1 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.2 EWC45351.1 - 0.0093 15.0 0.0 0.015 14.3 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 EWC45351.1 - 0.013 15.4 0.0 0.038 13.8 0.0 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 EWC45351.1 - 0.029 13.2 0.0 0.04 12.7 0.0 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A Lycopene_cycl PF05834.7 EWC45351.1 - 0.069 12.0 0.0 0.14 11.0 0.0 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein F-box-like PF12937.2 EWC45353.1 - 2.7e-07 30.2 0.7 2.7e-07 30.2 0.5 2.5 3 0 0 3 3 3 1 F-box-like F-box PF00646.28 EWC45353.1 - 0.00086 18.8 0.1 0.0024 17.4 0.1 1.8 1 0 0 1 1 1 1 F-box domain RNase_T PF00929.19 EWC45354.1 - 2.8e-29 102.4 0.0 4.3e-29 101.9 0.0 1.3 1 0 0 1 1 1 1 Exonuclease DNA_pol_A_exo1 PF01612.15 EWC45354.1 - 0.003 17.0 0.0 0.0086 15.5 0.0 1.7 1 1 0 1 1 1 1 3'-5' exonuclease FixP_N PF14715.1 EWC45355.1 - 0.56 9.6 3.0 14 5.1 0.6 2.6 2 0 0 2 2 2 0 N-terminal domain of cytochrome oxidase-cbb3, FixP MOR2-PAG1_N PF14222.1 EWC45356.1 - 5.6e-181 602.9 0.0 9e-181 602.2 0.0 1.3 1 0 0 1 1 1 1 Cell morphogenesis N-terminal MOR2-PAG1_C PF14225.1 EWC45356.1 - 1.4e-87 293.7 0.1 1.4e-87 293.7 0.0 2.3 3 0 0 3 3 3 1 Cell morphogenesis C-terminal MOR2-PAG1_mid PF14228.1 EWC45356.1 - 2.5e-45 154.5 1.7 2.1e-20 72.0 0.0 4.1 3 1 0 3 3 3 3 Cell morphogenesis central region HEAT PF02985.17 EWC45356.1 - 0.00067 19.5 0.8 13 6.1 0.0 6.2 7 0 0 7 7 7 1 HEAT repeat SRP72 PF08492.7 EWC45356.1 - 0.062 13.6 0.1 0.19 12.1 0.1 1.8 1 0 0 1 1 1 0 SRP72 RNA-binding domain FAD_binding_1 PF00667.15 EWC45357.1 - 3e-59 200.1 0.0 4.5e-59 199.5 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.20 EWC45357.1 - 6.6e-33 113.7 1.3 1.2e-32 112.8 0.9 1.5 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.16 EWC45357.1 - 1.3e-22 80.4 0.0 4.8e-22 78.5 0.0 2.0 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain RRM_1 PF00076.17 EWC45358.1 - 2.6e-24 84.6 0.0 2.4e-11 43.0 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EWC45358.1 - 1.4e-18 66.6 0.0 5.8e-09 35.7 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EWC45358.1 - 9.5e-06 25.3 0.0 0.00053 19.7 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RIO1 PF01163.17 EWC45359.1 - 2.4e-47 160.7 0.1 3.3e-47 160.2 0.0 1.2 1 0 0 1 1 1 1 RIO1 family Rio2_N PF09202.6 EWC45359.1 - 3.8e-33 113.3 0.0 8.8e-33 112.2 0.0 1.6 1 0 0 1 1 1 1 Rio2, N-terminal APH PF01636.18 EWC45359.1 - 1.6e-10 41.1 1.2 0.00013 21.7 0.4 2.7 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.9 EWC45359.1 - 1.1e-07 31.1 0.0 0.013 14.5 0.0 2.2 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family HTH_27 PF13463.1 EWC45359.1 - 0.12 12.7 0.0 0.23 11.8 0.0 1.5 1 0 0 1 1 1 0 Winged helix DNA-binding domain NUDIX PF00293.23 EWC45360.1 - 6.6e-29 100.2 0.0 9.9e-29 99.6 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain Acetyltransf_1 PF00583.19 EWC45361.1 - 4.3e-07 29.8 0.0 7.5e-07 29.0 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 EWC45361.1 - 8.1e-06 25.9 0.0 1.2e-05 25.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 EWC45361.1 - 2.3e-05 24.4 0.0 3.6e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 EWC45361.1 - 0.019 14.8 0.0 0.19 11.5 0.0 2.1 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 EWC45361.1 - 0.031 14.1 0.1 0.052 13.4 0.0 1.4 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain FR47 PF08445.5 EWC45361.1 - 0.16 11.7 0.0 0.48 10.2 0.0 1.7 2 0 0 2 2 2 0 FR47-like protein Syja_N PF02383.13 EWC45362.1 - 6.8e-86 287.9 0.0 1.7e-85 286.5 0.0 1.6 2 0 0 2 2 2 1 SacI homology domain DNA_mis_repair PF01119.14 EWC45363.1 - 1.8e-34 117.7 0.2 3e-34 117.0 0.2 1.4 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.1 EWC45363.1 - 8.8e-13 48.0 0.0 1.7e-12 47.1 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 EWC45363.1 - 1.2e-10 41.1 0.0 2.8e-10 39.9 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase TFIIS_C PF01096.13 EWC45364.1 - 9.8e-16 57.1 1.3 1.3e-15 56.7 0.9 1.2 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Terminase_GpA PF05876.7 EWC45364.1 - 0.00056 18.3 0.1 0.00056 18.3 0.1 1.0 1 0 0 1 1 1 1 Phage terminase large subunit (GpA) UPF0547 PF10571.4 EWC45364.1 - 0.0012 18.5 0.0 0.0024 17.5 0.0 1.5 1 1 0 1 1 1 1 Uncharacterised protein family UPF0547 Baculo_LEF5_C PF11792.3 EWC45364.1 - 0.0017 17.6 0.1 0.0027 17.0 0.1 1.3 1 0 0 1 1 1 1 Baculoviridae late expression factor 5 C-terminal domain DUF3716 PF12511.3 EWC45364.1 - 0.0025 17.3 0.2 0.0033 16.9 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3716) zf-H2C2_2 PF13465.1 EWC45364.1 - 0.0029 17.8 3.2 0.053 13.8 0.4 2.4 2 1 0 2 2 2 1 Zinc-finger double domain Lar_restr_allev PF14354.1 EWC45364.1 - 0.0054 16.9 0.7 0.007 16.6 0.5 1.2 1 0 0 1 1 1 1 Restriction alleviation protein Lar DZR PF12773.2 EWC45364.1 - 0.024 14.4 2.3 0.16 11.8 1.5 2.0 1 1 0 1 1 1 0 Double zinc ribbon zf-RING_3 PF14369.1 EWC45364.1 - 0.028 14.4 1.2 2.7 8.0 0.0 2.2 2 0 0 2 2 2 0 zinc-finger zf-DNA_Pol PF08996.5 EWC45364.1 - 0.028 13.7 0.2 0.034 13.5 0.1 1.1 1 0 0 1 1 1 0 DNA Polymerase alpha zinc finger zf-ribbon_3 PF13248.1 EWC45364.1 - 0.035 13.3 3.6 0.56 9.4 0.3 2.2 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_2 PF13240.1 EWC45364.1 - 0.054 12.9 1.8 3.9 7.0 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain Ogr_Delta PF04606.7 EWC45364.1 - 0.11 12.2 2.0 0.2 11.3 1.4 1.5 1 1 0 1 1 1 0 Ogr/Delta-like zinc finger zinc_ribbon_4 PF13717.1 EWC45364.1 - 0.12 12.0 3.7 0.75 9.5 0.7 2.3 2 0 0 2 2 2 0 zinc-ribbon domain CpXC PF14353.1 EWC45364.1 - 0.14 12.1 1.2 11 5.9 0.0 2.1 1 1 1 2 2 2 0 CpXC protein zinc_ribbon_5 PF13719.1 EWC45364.1 - 0.15 11.6 4.0 0.89 9.1 0.6 2.2 2 0 0 2 2 2 0 zinc-ribbon domain zf-C2H2 PF00096.21 EWC45364.1 - 0.19 12.1 4.3 0.85 10.0 0.8 2.4 2 0 0 2 2 2 0 Zinc finger, C2H2 type DUF329 PF03884.9 EWC45364.1 - 0.22 11.1 1.2 4.6 6.8 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF329) zf-C4_Topoisom PF01396.14 EWC45364.1 - 0.27 10.7 3.4 3.3 7.2 2.7 2.3 2 1 0 2 2 1 0 Topoisomerase DNA binding C4 zinc finger zinc-ribbons_6 PF07191.7 EWC45364.1 - 0.42 10.4 2.0 1 9.1 1.3 1.7 1 1 0 1 1 1 0 zinc-ribbons Sgf11 PF08209.6 EWC45364.1 - 0.46 9.8 3.4 1.9 7.8 0.6 2.2 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) TF_Zn_Ribbon PF08271.7 EWC45364.1 - 0.51 9.7 2.8 3.7 6.9 0.3 2.2 2 0 0 2 2 2 0 TFIIB zinc-binding DUF1610 PF07754.6 EWC45364.1 - 0.75 9.9 0.2 0.75 9.9 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1610) zf-Mss51 PF13824.1 EWC45364.1 - 1 9.2 3.4 4.6 7.1 2.3 1.9 1 1 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 zf-C2H2_4 PF13894.1 EWC45364.1 - 1.4 9.4 6.8 19 5.8 0.1 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger zf-HIT PF04438.11 EWC45364.1 - 2.5 7.8 10.2 0.44 10.2 2.5 2.1 2 0 0 2 2 2 0 HIT zinc finger Rubredoxin PF00301.15 EWC45364.1 - 3.3 7.6 5.5 5.2 7.0 0.4 2.2 2 0 0 2 2 2 0 Rubredoxin DNA_ligase_ZBD PF03119.11 EWC45364.1 - 5.7 6.7 6.7 4.6 7.0 0.1 2.3 2 0 0 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain C1_3 PF07649.7 EWC45364.1 - 6.9 6.7 6.5 3.8 7.6 0.2 2.1 2 0 0 2 2 2 0 C1-like domain Zn-ribbon_8 PF09723.5 EWC45364.1 - 9 6.3 7.1 18 5.3 0.7 2.3 1 1 1 2 2 2 0 Zinc ribbon domain HEAT_2 PF13646.1 EWC45365.1 - 6.2e-35 119.3 3.9 7.9e-14 51.7 0.0 4.1 2 2 2 4 4 4 4 HEAT repeats HEAT_PBS PF03130.11 EWC45365.1 - 3.4e-20 70.4 0.5 0.0091 16.3 0.1 6.9 8 0 0 8 8 8 4 PBS lyase HEAT-like repeat HEAT_EZ PF13513.1 EWC45365.1 - 1.1e-09 38.4 7.6 0.07 13.6 0.2 5.6 5 2 1 6 6 6 4 HEAT-like repeat HEAT PF02985.17 EWC45365.1 - 1e-08 34.5 8.8 0.038 14.0 0.0 7.1 8 1 0 8 8 8 2 HEAT repeat Arm PF00514.18 EWC45365.1 - 0.085 12.7 0.0 17 5.4 0.0 2.8 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat Hamartin PF04388.7 EWC45366.1 - 7.8e-52 176.8 4.5 7.8e-52 176.8 3.1 2.2 2 0 0 2 2 2 1 Hamartin protein Sec20 PF03908.8 EWC45366.1 - 2.5 7.8 10.2 2.1 8.1 0.8 2.9 3 0 0 3 3 3 0 Sec20 PAPS_reduct PF01507.14 EWC45367.1 - 2.5e-25 89.3 0.0 2.1e-18 66.7 0.0 3.5 2 1 0 2 2 2 2 Phosphoadenosine phosphosulfate reductase family Helicase_C PF00271.26 EWC45367.1 - 8.4e-09 35.1 0.0 3.7e-08 33.1 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SUV3_C PF12513.3 EWC45367.1 - 1e-05 24.8 0.1 2.2e-05 23.8 0.1 1.6 1 0 0 1 1 1 1 Mitochondrial degradasome RNA helicase subunit C terminal Sec1 PF00995.18 EWC45368.1 - 7.9e-108 361.5 0.0 9.3e-108 361.2 0.0 1.0 1 0 0 1 1 1 1 Sec1 family BTB PF00651.26 EWC45369.1 - 5.2e-07 29.6 0.1 1.6e-06 28.0 0.0 1.7 1 1 0 1 1 1 1 BTB/POZ domain DIM1 PF02966.11 EWC45370.1 - 2.2e-69 231.0 0.5 2.5e-69 230.9 0.4 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin PF00085.15 EWC45370.1 - 0.12 12.0 0.1 0.16 11.6 0.0 1.1 1 0 0 1 1 1 0 Thioredoxin RNase_H2_suC PF08615.6 EWC45371.1 - 2.7e-26 92.0 0.0 3.1e-26 91.8 0.0 1.0 1 0 0 1 1 1 1 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) Ank_4 PF13637.1 EWC45372.1 - 2.3e-06 27.9 0.1 0.063 13.8 0.0 3.1 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 EWC45372.1 - 0.0052 17.0 1.8 0.12 12.6 0.0 3.5 3 1 0 3 3 3 1 Ankyrin repeats (many copies) Ank_2 PF12796.2 EWC45372.1 - 0.0053 17.0 0.0 0.067 13.5 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.25 EWC45372.1 - 0.0059 16.3 0.1 0.072 12.9 0.0 2.9 4 0 0 4 4 4 1 Ankyrin repeat DUF1092 PF06485.6 EWC45373.1 - 0.0024 16.8 0.0 0.0042 16.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1092) Ank_4 PF13637.1 EWC45373.1 - 0.01 16.3 0.0 1.6 9.3 0.0 3.1 2 1 1 3 3 3 0 Ankyrin repeats (many copies) Ank_2 PF12796.2 EWC45373.1 - 0.01 16.1 0.0 0.029 14.7 0.0 1.7 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) Ank PF00023.25 EWC45373.1 - 0.012 15.3 0.2 0.12 12.2 0.0 2.7 3 0 0 3 3 3 0 Ankyrin repeat Laminin_II PF06009.7 EWC45373.1 - 0.038 13.7 5.2 0.58 9.9 0.3 3.4 2 1 1 3 3 3 0 Laminin Domain II NPV_P10 PF05531.7 EWC45373.1 - 0.11 12.7 1.8 22 5.3 0.0 3.9 4 0 0 4 4 4 0 Nucleopolyhedrovirus P10 protein Ank_3 PF13606.1 EWC45373.1 - 0.14 12.5 0.0 1.5 9.2 0.0 2.7 2 0 0 2 2 2 0 Ankyrin repeat MutS_III PF05192.13 EWC45373.1 - 0.18 11.5 3.6 1.1 9.0 2.4 2.4 1 1 0 1 1 1 0 MutS domain III DEAD PF00270.24 EWC45374.1 - 1.5e-43 148.1 0.1 2.2e-42 144.4 0.0 2.4 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EWC45374.1 - 1.3e-22 79.4 0.0 3e-22 78.2 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DBP10CT PF08147.7 EWC45374.1 - 2.2e-22 78.6 2.7 2.2e-22 78.6 1.9 2.1 2 0 0 2 2 2 1 DBP10CT (NUC160) domain RRM_1 PF00076.17 EWC45375.1 - 3.8e-26 90.4 0.1 1.9e-12 46.6 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EWC45375.1 - 6.7e-17 61.2 0.1 5.3e-07 29.5 0.0 2.7 3 0 0 3 3 3 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EWC45375.1 - 5.4e-16 58.1 0.0 5.9e-10 38.8 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Calcipressin PF04847.7 EWC45375.1 - 0.0021 17.6 0.0 0.0063 16.1 0.0 1.7 2 1 0 2 2 2 1 Calcipressin Limkain-b1 PF11608.3 EWC45375.1 - 0.028 14.1 0.1 0.073 12.8 0.0 1.8 2 0 0 2 2 2 0 Limkain b1 RPA_C PF08784.6 EWC45376.1 - 1.7e-14 54.0 0.2 1.7e-14 54.0 0.1 2.6 3 0 0 3 3 3 1 Replication protein A C terminal tRNA_anti-codon PF01336.20 EWC45376.1 - 0.00063 19.5 0.2 0.0018 18.1 0.0 1.9 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain Lum_binding PF00677.12 EWC45376.1 - 0.088 12.7 0.4 19 5.2 0.0 2.5 2 0 0 2 2 2 0 Lumazine binding domain HTH_6 PF01418.12 EWC45376.1 - 0.094 12.4 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain, rpiR family Ribosomal_L23 PF00276.15 EWC45377.1 - 1.4e-14 53.7 0.0 2.4e-14 53.0 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L23 PRE_C2HC PF07530.6 EWC45377.1 - 0.025 14.4 0.1 0.13 12.1 0.0 2.0 2 0 0 2 2 2 0 Associated with zinc fingers Thy1 PF02511.10 EWC45377.1 - 0.11 11.8 0.5 0.14 11.4 0.4 1.1 1 0 0 1 1 1 0 Thymidylate synthase complementing protein Glyco_transf_8 PF01501.15 EWC45378.1 - 3.9e-25 88.6 0.3 6.9e-25 87.8 0.2 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 8 Nucleotid_trans PF03407.11 EWC45378.1 - 0.0058 16.4 0.6 0.011 15.5 0.4 1.4 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Pyr_redox_2 PF07992.9 EWC45379.1 - 3.3e-18 66.3 0.0 6.7e-18 65.2 0.0 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 EWC45379.1 - 2.9e-12 46.8 0.0 6.1e-10 39.3 0.0 2.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase EF-hand_1 PF00036.27 EWC45379.1 - 3.3e-06 26.0 0.1 8e-06 24.8 0.0 1.7 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.1 EWC45379.1 - 4.8e-05 22.5 0.1 0.00012 21.2 0.1 1.6 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.1 EWC45379.1 - 0.00014 21.8 0.0 0.00043 20.3 0.0 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 EWC45379.1 - 0.00041 19.9 0.3 0.00041 19.9 0.2 2.1 2 0 0 2 2 2 1 EF-hand domain EF-hand_4 PF12763.2 EWC45379.1 - 0.092 12.4 0.1 0.3 10.8 0.0 1.8 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand G-patch PF01585.18 EWC45380.1 - 1.8e-10 40.4 1.9 3.4e-10 39.5 1.3 1.5 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.2 EWC45380.1 - 0.072 12.9 0.3 0.18 11.7 0.2 1.7 1 0 0 1 1 1 0 DExH-box splicing factor binding site zf-C2H2_2 PF12756.2 EWC45380.1 - 0.084 12.9 0.4 0.17 12.0 0.1 1.6 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) PNPOx_C PF10590.4 EWC45381.1 - 4e-19 67.8 2.1 9e-19 66.7 1.0 2.0 2 0 0 2 2 2 1 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region Pyridox_oxidase PF01243.15 EWC45381.1 - 8.6e-16 57.7 0.0 1.4e-15 57.0 0.0 1.3 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_oxase_2 PF12766.2 EWC45381.1 - 0.00099 19.3 0.1 0.0023 18.2 0.0 1.6 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase bZIP_2 PF07716.10 EWC45381.1 - 0.26 11.1 3.2 1.1 9.1 0.9 2.4 2 0 0 2 2 2 0 Basic region leucine zipper CDC27 PF09507.5 EWC45382.1 - 3.1e-74 250.7 28.0 3.8e-74 250.4 19.4 1.1 1 0 0 1 1 1 1 DNA polymerase subunit Cdc27 MOZ_SAS PF01853.13 EWC45383.1 - 3.9e-88 293.6 0.3 5.8e-88 293.0 0.2 1.3 1 0 0 1 1 1 1 MOZ/SAS family Tudor-knot PF11717.3 EWC45383.1 - 1.4e-21 75.9 0.1 3.1e-21 74.8 0.1 1.6 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain IF2_N PF04760.10 EWC45383.1 - 0.013 15.1 0.0 0.026 14.1 0.0 1.5 1 0 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region Patatin PF01734.17 EWC45384.1 - 2.6e-22 79.7 0.0 1.9e-21 76.9 0.0 2.4 1 1 0 1 1 1 1 Patatin-like phospholipase Ribonuc_L-PSP PF01042.16 EWC45386.1 - 1.2e-38 131.5 0.0 1.4e-38 131.3 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP DUF2529 PF10740.4 EWC45386.1 - 0.067 12.6 0.0 0.077 12.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2529) F_actin_cap_B PF01115.12 EWC45386.1 - 0.13 11.4 0.0 0.15 11.2 0.0 1.1 1 0 0 1 1 1 0 F-actin capping protein, beta subunit MFS_1 PF07690.11 EWC45388.1 - 1.6e-27 96.1 31.8 1.6e-27 96.1 22.1 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily DnaJ PF00226.26 EWC45389.1 - 2.4e-13 49.5 1.5 3.8e-13 48.9 0.3 1.9 2 0 0 2 2 2 1 DnaJ domain DEAD PF00270.24 EWC45390.1 - 5.2e-46 156.2 0.0 1.3e-45 154.9 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF4217 PF13959.1 EWC45390.1 - 2.8e-25 87.6 0.0 6.1e-25 86.5 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) Helicase_C PF00271.26 EWC45390.1 - 3.2e-21 74.9 0.0 8.2e-21 73.6 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Helicase_C_2 PF13307.1 EWC45390.1 - 0.003 17.5 0.0 0.0088 16.0 0.0 1.8 1 0 0 1 1 1 1 Helicase C-terminal domain AAA_19 PF13245.1 EWC45390.1 - 0.0055 16.4 0.0 0.2 11.4 0.0 2.6 2 0 0 2 2 2 1 Part of AAA domain DUF3337 PF11816.3 EWC45391.1 - 2.7e-67 227.5 0.0 9.7e-63 212.5 0.0 2.5 2 1 0 2 2 2 2 Domain of unknown function (DUF3337) WD40 PF00400.27 EWC45391.1 - 7.4e-30 101.7 18.2 3.3e-09 36.2 0.1 6.6 6 0 0 6 6 6 6 WD domain, G-beta repeat Nup160 PF11715.3 EWC45391.1 - 0.0037 15.4 0.1 0.0081 14.3 0.0 1.5 1 0 0 1 1 1 1 Nucleoporin Nup120/160 Anp1 PF03452.9 EWC45392.1 - 2e-118 394.4 0.0 4e-118 393.4 0.0 1.4 1 0 0 1 1 1 1 Anp1 Sec7 PF01369.15 EWC45393.1 - 5.6e-61 205.5 0.0 9.5e-61 204.7 0.0 1.4 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.2 EWC45393.1 - 1.8e-19 69.7 0.4 9.7e-12 44.6 0.1 3.1 3 0 0 3 3 3 2 Guanine nucleotide exchange factor in Golgi transport N-terminal DHC_N1 PF08385.7 EWC45394.1 - 2e-191 637.3 1.1 2e-191 637.3 0.8 5.0 5 1 2 7 7 7 1 Dynein heavy chain, N-terminal region 1 DHC_N2 PF08393.8 EWC45394.1 - 6.5e-128 426.7 7.1 6.5e-128 426.7 4.9 4.6 4 1 0 4 4 4 2 Dynein heavy chain, N-terminal region 2 Dynein_heavy PF03028.10 EWC45394.1 - 2.1e-105 353.3 0.0 6.1e-105 351.8 0.0 1.8 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor AAA_6 PF12774.2 EWC45394.1 - 2.5e-78 262.7 0.0 8.6e-78 261.0 0.0 2.0 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_9 PF12781.2 EWC45394.1 - 6.9e-43 146.1 0.1 2.2e-42 144.4 0.0 1.9 1 0 0 1 1 1 1 ATP-binding dynein motor region D5 AAA_8 PF12780.2 EWC45394.1 - 3.6e-40 137.6 0.2 7.5e-39 133.3 0.1 2.8 2 1 0 2 2 2 1 P-loop containing dynein motor region D4 MT PF12777.2 EWC45394.1 - 5.9e-38 130.4 4.8 2.9e-37 128.2 2.6 2.7 2 0 0 2 2 2 1 Microtubule-binding stalk of dynein motor AAA_5 PF07728.9 EWC45394.1 - 2.2e-31 108.4 0.2 3.4e-12 46.2 0.0 7.0 5 1 0 5 5 5 3 AAA domain (dynein-related subfamily) AAA_7 PF12775.2 EWC45394.1 - 2.8e-18 65.9 0.2 1.9e-17 63.2 0.0 2.4 3 0 0 3 3 2 1 P-loop containing dynein motor region D3 AAA_22 PF13401.1 EWC45394.1 - 1.3e-15 57.7 0.0 0.013 15.6 0.0 6.6 4 1 0 4 4 4 4 AAA domain AAA PF00004.24 EWC45394.1 - 1.7e-14 54.1 0.0 0.0013 18.9 0.0 5.3 5 0 0 5 5 4 3 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.1 EWC45394.1 - 1.5e-09 37.8 0.1 0.22 11.3 0.0 5.2 4 0 0 4 4 4 3 AAA domain AAA_18 PF13238.1 EWC45394.1 - 2e-09 37.8 1.3 0.056 13.7 0.0 6.8 7 0 0 7 7 6 2 AAA domain AAA_17 PF13207.1 EWC45394.1 - 2.1e-08 34.9 0.1 0.061 14.1 0.0 6.4 5 0 0 5 5 5 1 AAA domain AAA_16 PF13191.1 EWC45394.1 - 5.9e-08 32.9 6.7 0.17 11.8 0.0 7.4 6 1 1 7 7 7 2 AAA ATPase domain T2SE PF00437.15 EWC45394.1 - 1e-06 27.8 0.0 0.059 12.2 0.0 3.9 4 0 0 4 4 4 2 Type II/IV secretion system protein AAA_29 PF13555.1 EWC45394.1 - 4.5e-06 26.0 0.1 0.71 9.4 0.0 3.7 3 0 0 3 3 3 2 P-loop containing region of AAA domain ABC_tran PF00005.22 EWC45394.1 - 8.2e-06 26.1 0.0 0.41 10.9 0.0 4.7 3 0 0 3 3 3 1 ABC transporter Zeta_toxin PF06414.7 EWC45394.1 - 1.4e-05 24.2 0.0 0.61 9.1 0.0 4.3 4 0 0 4 4 4 2 Zeta toxin FtsK_SpoIIIE PF01580.13 EWC45394.1 - 2.8e-05 23.7 0.0 0.67 9.3 0.0 4.2 3 0 0 3 3 3 1 FtsK/SpoIIIE family AAA_19 PF13245.1 EWC45394.1 - 8.8e-05 22.1 0.0 0.89 9.3 0.0 4.1 4 0 0 4 4 4 1 Part of AAA domain Mg_chelatase PF01078.16 EWC45394.1 - 0.0002 20.6 0.9 0.5 9.4 0.0 3.9 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI DUF258 PF03193.11 EWC45394.1 - 0.0017 17.5 0.2 4.7 6.3 0.1 3.6 3 0 0 3 3 3 1 Protein of unknown function, DUF258 RNA_helicase PF00910.17 EWC45394.1 - 0.0023 18.0 0.2 14 5.9 0.0 5.3 6 0 0 6 6 5 0 RNA helicase MobB PF03205.9 EWC45394.1 - 0.011 15.4 0.2 7 6.3 0.0 4.1 4 0 0 4 4 4 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_25 PF13481.1 EWC45394.1 - 0.081 12.3 7.4 0.42 9.9 0.0 4.9 6 0 0 6 6 5 0 AAA domain tRNA_bind PF01588.15 EWC45395.1 - 7.3e-27 93.0 0.0 1.4e-26 92.1 0.0 1.5 1 0 0 1 1 1 1 Putative tRNA binding domain GST_C_3 PF14497.1 EWC45395.1 - 0.0011 19.3 0.0 0.0036 17.7 0.0 1.9 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 EWC45395.1 - 0.0012 18.6 0.0 0.0026 17.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 EWC45395.1 - 0.076 13.0 0.0 0.24 11.4 0.0 1.8 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain Acetyltransf_7 PF13508.1 EWC45396.1 - 0.00013 22.0 0.0 0.0003 20.8 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 EWC45396.1 - 0.00076 19.3 0.7 0.015 15.1 0.2 2.9 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 EWC45396.1 - 0.00079 19.4 0.2 0.057 13.4 0.1 2.7 2 1 0 2 2 2 1 Acetyltransferase (GNAT) family Nuf2 PF03800.9 EWC45397.1 - 2.7e-31 108.5 0.0 8.5e-31 106.9 0.0 1.8 1 0 0 1 1 1 1 Nuf2 family IncA PF04156.9 EWC45397.1 - 3.9e-06 26.6 10.8 3.9e-06 26.6 7.5 3.0 2 1 0 2 2 2 1 IncA protein DUF948 PF06103.6 EWC45397.1 - 0.43 10.4 5.6 23 4.9 0.0 4.1 3 2 3 6 6 6 0 Bacterial protein of unknown function (DUF948) Meth_synt_2 PF01717.13 EWC45398.1 - 8e-16 57.9 0.0 2.6e-12 46.3 0.0 2.1 2 0 0 2 2 2 2 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.7 EWC45398.1 - 0.00071 18.9 0.0 0.012 14.9 0.0 2.6 3 0 0 3 3 3 1 Cobalamin-independent synthase, N-terminal domain Nramp PF01566.13 EWC45399.1 - 1.2e-87 293.9 18.8 2.2e-87 293.1 13.0 1.4 1 0 0 1 1 1 1 Natural resistance-associated macrophage protein RNA_pol_N PF01194.12 EWC45401.1 - 0.044 13.8 0.0 0.092 12.7 0.0 1.5 1 0 0 1 1 1 0 RNA polymerases N / 8 kDa subunit APH PF01636.18 EWC45402.1 - 9.1e-11 41.9 0.3 1.3e-10 41.4 0.2 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family PDCD9 PF07147.7 EWC45402.1 - 0.2 10.3 0.2 4.8 5.8 0.0 2.0 2 0 0 2 2 2 0 Mitochondrial 28S ribosomal protein S30 (PDCD9) Mito_carr PF00153.22 EWC45403.1 - 6.8e-59 195.5 3.7 1e-21 76.4 0.1 4.2 4 0 0 4 4 4 4 Mitochondrial carrier protein Kelch_5 PF13854.1 EWC45404.1 - 0.00022 21.0 0.1 0.00022 21.0 0.1 3.6 4 0 0 4 4 4 1 Kelch motif Kelch_4 PF13418.1 EWC45404.1 - 0.0012 18.6 2.6 0.15 11.8 0.1 3.9 4 0 0 4 4 4 1 Galactose oxidase, central domain DUF4229 PF14012.1 EWC45404.1 - 0.096 12.5 0.5 0.17 11.8 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4229) Kelch_6 PF13964.1 EWC45404.1 - 0.31 11.2 9.4 3.8 7.8 0.0 4.9 6 0 0 6 6 6 0 Kelch motif Romo1 PF10247.4 EWC45404.1 - 0.51 10.5 2.8 1.5 9.0 0.0 2.7 3 0 0 3 3 3 0 Reactive mitochondrial oxygen species modulator 1 Pex14_N PF04695.8 EWC45406.1 - 0.27 11.3 2.6 0.4 10.7 1.8 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region NIR_SIR PF01077.17 EWC45407.1 - 6.2e-52 175.1 0.0 2.1e-44 150.6 0.0 2.4 2 0 0 2 2 2 2 Nitrite and sulphite reductase 4Fe-4S domain NIR_SIR_ferr PF03460.12 EWC45407.1 - 4e-32 109.6 0.0 3.9e-15 55.2 0.0 2.6 2 0 0 2 2 2 2 Nitrite/Sulfite reductase ferredoxin-like half domain Flavodoxin_1 PF00258.20 EWC45407.1 - 1.3e-29 103.0 0.0 2.4e-29 102.1 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin POR_N PF01855.14 EWC45407.1 - 1.7e-07 31.0 0.3 3.3e-07 30.0 0.0 1.6 2 0 0 2 2 2 1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg VSP PF03302.8 EWC45408.1 - 0.0014 17.3 1.0 0.0025 16.5 0.7 1.5 1 0 0 1 1 1 1 Giardia variant-specific surface protein Podoplanin PF05808.6 EWC45408.1 - 0.0059 16.1 0.5 0.012 15.2 0.3 1.4 1 0 0 1 1 1 1 Podoplanin DUF2029 PF09594.5 EWC45408.1 - 1.3 8.4 8.2 0.077 12.4 1.7 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF2029) Granulin PF00396.13 EWC45408.1 - 5.6 7.1 6.1 4 7.6 0.4 2.6 3 0 0 3 3 3 0 Granulin Svf1 PF08622.5 EWC45409.1 - 4e-113 377.6 0.0 4.5e-113 377.4 0.0 1.0 1 0 0 1 1 1 1 Svf1-like UMP1 PF05348.6 EWC45410.1 - 1.1e-12 48.0 0.0 1.2e-12 47.8 0.0 1.1 1 0 0 1 1 1 1 Proteasome maturation factor UMP1 Npa1 PF11707.3 EWC45411.1 - 5.3e-85 285.3 0.0 2.6e-84 283.0 0.0 2.1 3 0 0 3 3 3 1 Ribosome 60S biogenesis N-terminal BsuPI PF12690.2 EWC45413.1 - 0.11 12.2 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 Intracellular proteinase inhibitor Rad60-SLD_2 PF13881.1 EWC45415.1 - 2.5e-11 43.4 0.0 2.7e-11 43.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.18 EWC45415.1 - 8e-06 25.1 0.0 1.4e-05 24.3 0.0 1.4 2 0 0 2 2 2 1 Ubiquitin family DUF2407 PF10302.4 EWC45415.1 - 0.06 13.5 0.0 0.067 13.3 0.0 1.2 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain GATA PF00320.22 EWC45417.1 - 2.5e-30 103.5 18.0 3.6e-16 58.2 2.6 2.5 2 0 0 2 2 2 2 GATA zinc finger TF_Zn_Ribbon PF08271.7 EWC45417.1 - 7e-06 25.2 3.2 0.014 14.7 0.1 2.5 2 0 0 2 2 2 2 TFIIB zinc-binding RRN7 PF11781.3 EWC45417.1 - 0.0002 20.8 5.0 0.19 11.2 0.3 2.5 2 0 0 2 2 2 2 RNA polymerase I-specific transcription initiation factor Rrn7 ArfGap PF01412.13 EWC45417.1 - 0.00066 19.4 3.8 0.33 10.7 0.2 2.5 2 0 0 2 2 2 2 Putative GTPase activating protein for Arf Zn-ribbon_8 PF09723.5 EWC45417.1 - 0.0031 17.4 1.2 1.1 9.2 0.2 2.8 2 0 0 2 2 2 2 Zinc ribbon domain zf-Sec23_Sec24 PF04810.10 EWC45417.1 - 0.051 13.1 0.4 0.051 13.1 0.3 2.8 3 0 0 3 3 3 0 Sec23/Sec24 zinc finger Zn_Tnp_IS1595 PF12760.2 EWC45417.1 - 0.11 12.2 4.6 0.85 9.4 0.2 2.6 2 0 0 2 2 2 0 Transposase zinc-ribbon domain DZR PF12773.2 EWC45417.1 - 0.35 10.7 13.5 2.2 8.1 1.2 3.4 2 2 1 3 3 3 0 Double zinc ribbon zf-ribbon_3 PF13248.1 EWC45417.1 - 0.82 8.9 11.8 0.72 9.1 0.4 3.1 2 1 0 2 2 2 0 zinc-ribbon domain Auto_anti-p27 PF06677.7 EWC45417.1 - 0.9 9.3 3.6 20 5.0 0.2 2.6 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) zf-C2H2_3 PF13878.1 EWC45417.1 - 1.1 8.8 8.2 10 5.8 0.1 4.2 3 1 1 4 4 4 0 zinc-finger of acetyl-transferase ESCO eIF-5_eIF-2B PF01873.12 EWC45417.1 - 1.7 8.3 5.3 14 5.3 0.5 2.4 2 0 0 2 2 2 0 Domain found in IF2B/IF5 DUF2318 PF10080.4 EWC45417.1 - 4.3 7.1 5.8 1 9.1 0.0 2.6 2 1 0 2 2 2 0 Predicted membrane protein (DUF2318) Oligomerisation PF02410.10 EWC45418.1 - 2.1e-08 34.0 0.0 5.9e-08 32.6 0.0 1.8 1 0 0 1 1 1 1 Oligomerisation domain cwf21 PF08312.7 EWC45418.1 - 0.03 14.1 5.6 0.072 12.9 0.4 3.5 3 1 0 3 3 3 0 cwf21 domain DcpS_C PF11969.3 EWC45419.1 - 5e-30 104.1 1.9 6.9e-30 103.6 0.9 1.5 2 0 0 2 2 2 1 Scavenger mRNA decapping enzyme C-term binding DcpS PF05652.7 EWC45419.1 - 6.8e-30 103.7 0.0 1.1e-29 103.0 0.0 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme (DcpS) N-terminal DUF3252 PF11623.3 EWC45419.1 - 0.11 11.9 0.0 0.35 10.3 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3252) HIT PF01230.18 EWC45419.1 - 0.11 13.0 0.9 0.31 11.5 0.6 1.9 1 1 0 1 1 1 0 HIT domain Mito_carr PF00153.22 EWC45423.1 - 1.1e-44 150.0 14.2 9.2e-19 66.9 0.3 3.8 3 1 0 3 3 3 3 Mitochondrial carrier protein DUF2036 PF09724.4 EWC45424.1 - 6e-28 97.9 0.0 7.6e-28 97.5 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2036) RhoGEF PF00621.15 EWC45425.1 - 1.1e-21 77.4 0.0 4.5e-21 75.5 0.0 2.0 1 0 0 1 1 1 1 RhoGEF domain DUF3507 PF12015.3 EWC45425.1 - 0.0002 20.9 0.0 0.0004 19.9 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3507) RhoGAP PF00620.22 EWC45425.1 - 0.0024 17.4 0.0 0.0085 15.7 0.0 1.9 1 0 0 1 1 1 1 RhoGAP domain tRNA-synt_1 PF00133.17 EWC45426.1 - 7.2e-210 698.0 0.2 5.1e-209 695.2 0.1 2.1 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.6 EWC45426.1 - 1.7e-20 73.0 3.9 3.1e-11 42.5 0.0 5.0 4 2 0 4 4 4 2 tRNA synthetases class I (M) Anticodon_1 PF08264.8 EWC45426.1 - 2.2e-15 56.7 1.5 1.3e-14 54.2 0.5 2.6 1 1 1 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1_2 PF13603.1 EWC45426.1 - 2.7e-10 39.8 6.4 2.1e-08 33.6 0.0 3.0 2 1 1 3 3 3 2 Leucyl-tRNA synthetase, Domain 2 Git3 PF11710.3 EWC45428.1 - 4.5e-61 205.9 16.5 4.5e-61 205.9 11.4 1.5 2 0 0 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 Git3_C PF11970.3 EWC45428.1 - 2.3e-27 94.5 2.0 2.3e-27 94.5 1.4 2.1 2 0 0 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 C-term 7TM_GPCR_Srsx PF10320.4 EWC45428.1 - 0.0059 15.7 4.0 0.01 14.9 2.8 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx adh_short PF00106.20 EWC45429.1 - 3e-13 50.0 0.1 6.1e-11 42.5 0.0 2.3 2 0 0 2 2 2 2 short chain dehydrogenase KR PF08659.5 EWC45429.1 - 4.5e-08 32.9 0.0 8.7e-08 32.0 0.0 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 EWC45429.1 - 0.012 15.0 0.0 0.12 11.8 0.0 2.1 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 EWC45429.1 - 0.015 15.2 0.1 0.026 14.5 0.1 1.3 1 0 0 1 1 1 0 NADH(P)-binding HA2 PF04408.18 EWC45430.1 - 1.5e-29 101.9 0.0 6.9e-29 99.8 0.0 2.2 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.11 EWC45430.1 - 2.7e-26 91.6 0.1 6.7e-26 90.3 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.26 EWC45430.1 - 8.1e-13 48.0 0.0 2.6e-12 46.3 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain S1 PF00575.18 EWC45430.1 - 5e-12 45.7 0.9 1e-11 44.7 0.6 1.5 1 0 0 1 1 1 1 S1 RNA binding domain T2SE PF00437.15 EWC45430.1 - 5.6e-06 25.4 0.1 1.2e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein DEAD PF00270.24 EWC45430.1 - 1.5e-05 24.5 0.1 3.4e-05 23.3 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 EWC45430.1 - 2.5e-05 24.4 0.0 6.6e-05 23.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.1 EWC45430.1 - 0.0011 18.6 0.1 0.0085 15.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 EWC45430.1 - 0.019 14.7 0.2 0.062 13.0 0.1 1.9 1 0 0 1 1 1 0 Part of AAA domain ResIII PF04851.10 EWC45430.1 - 0.039 13.7 0.0 3.7 7.3 0.0 2.5 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_14 PF13173.1 EWC45430.1 - 0.082 12.8 0.2 0.72 9.7 0.1 2.4 2 1 0 2 2 2 0 AAA domain ABC_tran PF00005.22 EWC45430.1 - 0.36 11.1 3.5 1.2 9.3 0.0 3.1 2 1 1 3 3 3 0 ABC transporter Peptidase_C12 PF01088.16 EWC45431.1 - 3e-56 189.9 0.0 3.5e-56 189.7 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 Ribosomal_S7 PF00177.16 EWC45432.1 - 5.7e-24 84.3 0.0 8.5e-24 83.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e Nipped-B_C PF12830.2 EWC45433.1 - 1.3e-47 161.8 9.8 9.7e-46 155.7 0.1 4.9 5 1 1 6 6 6 2 Sister chromatid cohesion C-terminus Cohesin_HEAT PF12765.2 EWC45433.1 - 1.5e-08 34.3 3.2 4.1e-07 29.8 0.2 3.6 3 0 0 3 3 3 1 HEAT repeat associated with sister chromatid cohesion HEAT_2 PF13646.1 EWC45433.1 - 2e-07 31.2 3.6 0.00052 20.2 0.1 5.0 4 0 0 4 4 4 2 HEAT repeats HEAT PF02985.17 EWC45433.1 - 5.5e-07 29.1 4.6 0.013 15.5 0.0 4.9 5 0 0 5 5 5 3 HEAT repeat HEAT_EZ PF13513.1 EWC45433.1 - 0.52 10.8 4.5 45 4.7 0.1 5.0 5 0 0 5 5 5 0 HEAT-like repeat DUF1183 PF06682.7 EWC45434.1 - 1.9 8.0 7.3 2.2 7.7 5.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1183) Abhydrolase_4 PF08386.5 EWC45435.1 - 2.3e-18 65.9 0.0 4.9e-18 64.9 0.0 1.6 1 0 0 1 1 1 1 TAP-like protein Abhydrolase_1 PF00561.15 EWC45435.1 - 1.1e-12 48.0 0.0 2.4e-11 43.6 0.0 2.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 EWC45435.1 - 9e-09 35.5 0.0 5.4e-08 33.0 0.0 2.2 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EWC45435.1 - 0.02 14.6 0.1 3.3 7.4 0.0 2.5 2 1 0 2 2 2 0 Alpha/beta hydrolase family DUF1972 PF09314.6 EWC45435.1 - 0.1 12.0 0.0 0.2 11.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1972) UPF0086 PF01868.11 EWC45436.1 - 4.9e-27 93.3 0.0 8.3e-27 92.6 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function UPF0086 WD40 PF00400.27 EWC45438.1 - 7.9e-13 47.7 7.3 0.15 12.0 0.0 7.5 7 0 0 7 7 7 6 WD domain, G-beta repeat ATP_bind_3 PF01171.15 EWC45440.1 - 2.5e-47 160.7 0.2 5.1e-47 159.7 0.0 1.6 2 0 0 2 2 2 1 PP-loop family NAD_synthase PF02540.12 EWC45440.1 - 5.8e-05 22.0 0.0 0.00011 21.2 0.0 1.3 1 0 0 1 1 1 1 NAD synthase Asn_synthase PF00733.16 EWC45440.1 - 0.001 18.6 0.2 0.0024 17.4 0.1 1.6 1 1 0 1 1 1 1 Asparagine synthase Cullin_binding PF03556.10 EWC45441.1 - 1.4e-19 70.3 0.7 2.3e-19 69.6 0.5 1.4 1 0 0 1 1 1 1 Cullin binding DNA_pol_viral_N PF00242.12 EWC45441.1 - 0.95 8.4 5.3 1.3 8.0 3.7 1.1 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain Cpn10 PF00166.16 EWC45442.1 - 6.1e-25 86.9 0.0 6.8e-25 86.8 0.0 1.0 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit PolyA_pol_RNAbd PF12627.2 EWC45442.1 - 0.022 14.3 0.4 0.065 12.8 0.3 1.8 1 1 0 1 1 1 0 Probable RNA and SrmB- binding site of polymerase A Rhomboid PF01694.17 EWC45443.1 - 5.5e-14 52.4 14.3 1.3e-13 51.2 7.9 2.5 2 1 0 2 2 2 1 Rhomboid family Pam17 PF08566.5 EWC45443.1 - 0.064 12.9 0.0 0.1 12.3 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial import protein Pam17 Pkinase PF00069.20 EWC45444.1 - 5.4e-58 196.1 0.0 8.5e-58 195.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC45444.1 - 2.9e-20 72.4 0.0 5.4e-20 71.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 EWC45444.1 - 0.012 15.3 0.3 0.025 14.3 0.2 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.1 EWC45444.1 - 0.031 13.2 0.0 0.093 11.6 0.0 1.7 2 0 0 2 2 2 0 Kinase-like Kdo PF06293.9 EWC45444.1 - 0.059 12.4 0.1 0.11 11.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ribosomal_L11_N PF03946.9 EWC45445.1 - 1.8e-26 91.3 0.1 3.5e-26 90.4 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.14 EWC45445.1 - 2.2e-25 88.5 0.9 2.7e-25 88.3 0.1 1.5 2 0 0 2 2 2 1 Ribosomal protein L11, RNA binding domain Fip1 PF05182.8 EWC45447.1 - 2.6e-20 71.4 1.4 2.6e-20 71.4 1.0 1.8 2 0 0 2 2 2 1 Fip1 motif CENP-T PF15511.1 EWC45447.1 - 2.1 7.5 18.6 0.49 9.5 8.4 2.1 2 0 0 2 2 2 0 Centromere kinetochore component CENP-T Nucleoporin_FG PF13634.1 EWC45448.1 - 1e-22 80.4 103.8 1.7e-11 44.3 29.9 3.5 1 1 2 3 3 3 3 Nucleoporin FG repeat region T2SJ PF11612.3 EWC45448.1 - 0.081 12.6 0.0 11 5.6 0.0 2.3 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein J zf-RING_5 PF14634.1 EWC45449.1 - 6.3e-06 25.8 6.0 1.1e-05 24.9 4.2 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.1 EWC45449.1 - 8.6e-05 22.2 5.9 0.00015 21.5 4.1 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 EWC45449.1 - 0.0024 17.8 3.6 0.0046 16.9 2.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) DUF972 PF06156.8 EWC45449.1 - 0.0042 17.4 4.1 0.011 16.0 2.8 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF972) zf-C3HC4 PF00097.20 EWC45449.1 - 0.0067 16.0 6.8 0.013 15.1 4.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) DUF948 PF06103.6 EWC45449.1 - 0.073 12.9 2.7 0.14 12.0 1.8 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) IncA PF04156.9 EWC45449.1 - 0.1 12.2 3.3 0.16 11.5 2.3 1.3 1 0 0 1 1 1 0 IncA protein Spc7 PF08317.6 EWC45449.1 - 0.14 10.7 6.6 0.24 10.0 4.6 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein zf-C3HC4_4 PF15227.1 EWC45449.1 - 0.23 11.3 5.6 0.47 10.3 3.9 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING V_ATPase_I PF01496.14 EWC45449.1 - 0.24 9.2 1.4 0.31 8.8 1.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF724 PF05266.9 EWC45449.1 - 0.26 10.8 2.7 0.49 9.9 1.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) SlyX PF04102.7 EWC45449.1 - 0.37 11.1 3.5 3 8.2 2.3 2.5 1 1 1 2 2 2 0 SlyX DUF904 PF06005.7 EWC45449.1 - 0.46 10.8 9.9 1.4 9.2 6.9 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF904) DUF848 PF05852.6 EWC45449.1 - 0.69 9.7 6.3 0.28 11.0 2.1 1.9 2 0 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) zf-rbx1 PF12678.2 EWC45449.1 - 1 9.5 5.2 1.8 8.7 3.6 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger ADIP PF11559.3 EWC45449.1 - 1.1 9.1 13.1 0.15 11.9 6.0 1.7 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding CASP_C PF08172.7 EWC45449.1 - 2.4 7.0 8.6 1 8.3 3.6 2.1 2 1 0 2 2 2 0 CASP C terminal TMF_DNA_bd PF12329.3 EWC45449.1 - 4.4 7.1 11.2 36 4.2 7.9 2.2 1 1 0 1 1 1 0 TATA element modulatory factor 1 DNA binding DivIC PF04977.10 EWC45449.1 - 7.4 6.1 11.0 19 4.8 5.7 2.8 1 1 1 2 2 2 0 Septum formation initiator DUF4387 PF14330.1 EWC45450.1 - 9e-37 125.3 0.0 1.7e-36 124.5 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4387) DUF1446 PF07287.6 EWC45450.1 - 3.6e-18 65.1 0.0 3e-08 32.5 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1446) Aldolase_II PF00596.16 EWC45451.1 - 2.4e-45 154.3 0.2 3e-45 154.0 0.2 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain COesterase PF00135.23 EWC45452.1 - 3.9e-68 230.4 0.0 1e-67 229.0 0.0 1.5 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 EWC45452.1 - 7.1e-11 42.0 0.0 1.3e-10 41.2 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 EWC45452.1 - 0.0025 17.0 0.0 0.0047 16.1 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family DUF605 PF04652.11 EWC45454.1 - 5.3 6.3 49.1 7.2 5.8 34.1 1.1 1 0 0 1 1 1 0 Vta1 like NAGidase PF07555.8 EWC45455.1 - 0.046 12.6 1.5 0.062 12.1 1.0 1.2 1 0 0 1 1 1 0 beta-N-acetylglucosaminidase RPW8 PF05659.6 EWC45455.1 - 0.085 12.4 1.4 0.16 11.5 0.6 1.6 1 1 0 1 1 1 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 DnaB_bind PF10410.4 EWC45455.1 - 0.16 11.9 1.7 12 5.9 0.1 3.5 4 0 0 4 4 4 0 DnaB-helicase binding domain of primase GCIP PF13324.1 EWC45455.1 - 0.16 11.1 11.8 2.3 7.3 5.0 2.2 1 1 1 2 2 2 0 Grap2 and cyclin-D-interacting DUF2422 PF10337.4 EWC45455.1 - 0.31 9.7 1.4 0.4 9.4 1.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2422) Gly-zipper_OmpA PF13436.1 EWC45457.1 - 0.059 13.0 3.2 0.073 12.7 2.2 1.1 1 0 0 1 1 1 0 Glycine-zipper containing OmpA-like membrane domain VirionAssem_T7 PF11653.3 EWC45457.1 - 1.7 9.4 4.8 4.4 8.1 0.1 2.1 2 0 0 2 2 2 0 Bacteriophage T7 virion assembly protein WD40 PF00400.27 EWC45458.1 - 1e-06 28.3 7.4 2.8 7.9 0.1 5.7 5 1 0 5 5 5 5 WD domain, G-beta repeat F-box-like PF12937.2 EWC45459.1 - 1.1e-05 25.0 0.1 2.7e-05 23.7 0.0 1.7 1 0 0 1 1 1 1 F-box-like DUF1675 PF07897.6 EWC45459.1 - 0.15 11.9 1.4 0.34 10.7 1.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) MFS_1 PF07690.11 EWC45460.1 - 5.1e-22 78.0 47.3 3.8e-21 75.1 32.8 2.4 1 1 0 1 1 1 1 Major Facilitator Superfamily hEGF PF12661.2 EWC45461.1 - 0.061 13.4 1.6 0.18 11.9 1.1 1.9 1 0 0 1 1 1 0 Human growth factor-like EGF DUF3129 PF11327.3 EWC45462.1 - 4.3e-62 209.2 0.0 1.5e-61 207.4 0.0 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF3129) Pentapeptide_2 PF01469.13 EWC45462.1 - 0.0022 17.5 45.8 0.0022 17.5 31.7 4.0 2 1 1 3 3 3 1 Pentapeptide repeats (8 copies) An_peroxidase PF03098.10 EWC45463.1 - 6.6e-85 285.4 0.0 1.4e-82 277.8 0.0 2.2 1 1 0 1 1 1 1 Animal haem peroxidase p450 PF00067.17 EWC45463.1 - 2.5e-05 22.9 0.1 0.0002 20.0 0.0 2.0 2 0 0 2 2 2 1 Cytochrome P450 An_peroxidase PF03098.10 EWC45464.1 - 4.6e-77 259.6 0.0 4.2e-75 253.1 0.0 2.2 1 1 0 1 1 1 1 Animal haem peroxidase p450 PF00067.17 EWC45464.1 - 5.2e-09 35.1 0.0 4.2e-08 32.1 0.0 2.0 2 0 0 2 2 2 1 Cytochrome P450 DUF3485 PF11984.3 EWC45464.1 - 0.11 11.6 0.0 0.22 10.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3485) Peroxidase_2 PF01328.12 EWC45465.1 - 1.2e-21 76.7 0.1 2.2e-21 75.8 0.0 1.4 2 0 0 2 2 2 1 Peroxidase, family 2 DDHD PF02862.12 EWC45466.1 - 1.6e-38 132.7 0.1 2.1e-23 83.2 0.0 2.6 2 1 0 3 3 3 2 DDHD domain Abhydrolase_6 PF12697.2 EWC45466.1 - 0.0056 16.5 0.0 0.016 15.0 0.0 1.8 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EWC45466.1 - 0.013 15.2 0.0 0.028 14.1 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family OppC_N PF12911.2 EWC45468.1 - 0.021 14.1 2.0 0.13 11.7 0.0 2.9 3 0 0 3 3 3 0 N-terminal TM domain of oligopeptide transport permease C SLAC1 PF03595.12 EWC45468.1 - 0.024 13.2 8.1 0.34 9.5 5.5 2.0 1 1 0 1 1 1 0 Voltage-dependent anion channel DUF389 PF04087.9 EWC45468.1 - 0.031 14.2 0.4 0.35 10.7 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF389) PDR_CDR PF06422.7 EWC45468.1 - 0.054 13.1 1.0 0.11 12.2 0.1 1.8 2 0 0 2 2 2 0 CDR ABC transporter SET PF00856.23 EWC45469.1 - 6.8e-07 29.7 0.2 1.7e-05 25.1 0.0 2.7 2 1 0 2 2 2 1 SET domain TPR_11 PF13414.1 EWC45469.1 - 0.0002 20.9 0.2 0.0002 20.9 0.1 2.6 2 1 1 3 3 3 2 TPR repeat TPR_2 PF07719.12 EWC45469.1 - 0.0068 16.2 5.9 7.4 6.7 0.2 4.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.1 EWC45469.1 - 0.016 15.8 0.3 0.54 10.9 0.2 3.2 2 1 0 2 2 2 0 Tetratricopeptide repeat Apc3 PF12895.2 EWC45469.1 - 0.024 14.7 0.3 0.66 10.1 0.1 2.7 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.1 EWC45469.1 - 0.19 11.6 6.3 0.089 12.7 0.3 3.2 2 1 1 3 3 3 0 Tetratricopeptide repeat zf-C2H2_4 PF13894.1 EWC45470.1 - 0.019 15.2 8.1 1.3 9.5 0.0 3.1 3 0 0 3 3 3 0 C2H2-type zinc finger IBR PF01485.16 EWC45470.1 - 0.028 14.2 2.0 2 8.3 0.1 2.2 2 0 0 2 2 2 0 IBR domain zinc_ribbon_4 PF13717.1 EWC45470.1 - 0.086 12.5 0.1 0.18 11.4 0.1 1.5 1 0 0 1 1 1 0 zinc-ribbon domain zf-C2H2 PF00096.21 EWC45470.1 - 0.11 12.9 13.3 0.61 10.5 3.2 3.2 2 1 0 2 2 2 0 Zinc finger, C2H2 type PQ-loop PF04193.9 EWC45471.1 - 0.016 14.7 11.9 0.033 13.7 0.1 4.0 4 0 0 4 4 4 0 PQ loop repeat Polyketide_cyc2 PF10604.4 EWC45472.1 - 0.00017 21.7 0.4 0.00029 21.0 0.3 1.4 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport zf-C2H2_4 PF13894.1 EWC45474.1 - 4.8e-08 32.7 2.8 0.0027 17.9 0.4 3.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.21 EWC45474.1 - 0.00018 21.6 13.4 0.0045 17.2 2.3 3.7 3 1 0 3 3 3 2 Zinc finger, C2H2 type zf-met PF12874.2 EWC45474.1 - 0.012 15.8 1.8 0.043 14.0 1.3 2.0 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.1 EWC45474.1 - 0.019 15.2 10.3 1.4 9.3 0.2 3.7 3 0 0 3 3 3 0 Zinc-finger double domain zf-H2C2_5 PF13909.1 EWC45474.1 - 0.022 14.9 3.7 2.6 8.4 0.9 2.9 2 0 0 2 2 2 0 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.3 EWC45474.1 - 0.051 13.7 0.9 0.051 13.7 0.6 2.3 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.7 EWC45474.1 - 0.066 13.3 3.0 0.26 11.4 0.4 2.7 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-BED PF02892.10 EWC45474.1 - 0.29 10.9 7.1 1.4 8.7 0.4 3.1 3 0 0 3 3 3 0 BED zinc finger zf-C2H2_6 PF13912.1 EWC45474.1 - 0.55 10.2 6.3 0.2 11.6 1.1 2.7 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_2 PF12756.2 EWC45474.1 - 1.6 8.8 4.7 2.8 8.1 1.0 2.5 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) adh_short PF00106.20 EWC45475.1 - 3e-16 59.8 0.1 5.6e-16 58.9 0.0 1.5 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.5 EWC45475.1 - 2.2e-09 37.2 0.0 3.4e-09 36.6 0.0 1.2 1 0 0 1 1 1 1 KR domain Myelin-PO_C PF10570.4 EWC45475.1 - 0.14 12.2 0.1 0.31 11.1 0.1 1.5 1 0 0 1 1 1 0 Myelin-PO cytoplasmic C-term p65 binding region NAD_binding_10 PF13460.1 EWC45475.1 - 0.14 12.1 0.4 0.28 11.1 0.3 1.4 1 0 0 1 1 1 0 NADH(P)-binding Citrate_synt PF00285.16 EWC45476.1 - 1.3e-17 63.6 0.0 3.3e-15 55.6 0.0 2.8 1 1 1 2 2 2 2 Citrate synthase Ligase_CoA PF00549.14 EWC45476.1 - 1.5e-17 63.6 0.1 2.9e-17 62.6 0.0 1.5 1 0 0 1 1 1 1 CoA-ligase CoA_binding PF02629.14 EWC45476.1 - 4.3e-15 55.9 0.0 1.1e-14 54.6 0.0 1.8 1 0 0 1 1 1 1 CoA binding domain Succ_CoA_lig PF13607.1 EWC45476.1 - 1.4e-06 27.9 0.0 1.8e-05 24.3 0.0 2.3 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.1 EWC45476.1 - 0.075 13.1 0.0 0.16 12.1 0.0 1.5 1 0 0 1 1 1 0 CoA binding domain ATP-grasp_2 PF08442.5 EWC45477.1 - 1.1e-08 34.6 0.0 1.7e-08 34.1 0.0 1.2 1 0 0 1 1 1 1 ATP-grasp domain TPR_11 PF13414.1 EWC45478.1 - 2.1e-08 33.6 0.0 3.4e-07 29.8 0.0 2.3 2 0 0 2 2 2 1 TPR repeat TPR_2 PF07719.12 EWC45478.1 - 0.0019 17.9 0.1 1.8 8.6 0.1 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.23 EWC45478.1 - 0.0045 16.5 0.7 1.7 8.4 0.0 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 EWC45478.1 - 0.031 14.1 0.4 0.16 11.9 0.2 2.1 1 1 1 2 2 2 0 Tetratricopeptide repeat HAD_2 PF13419.1 EWC45479.1 - 1.4e-14 54.7 0.0 3.9e-13 49.9 0.0 2.1 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 EWC45479.1 - 5.7e-06 25.9 0.0 1.1e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.21 EWC45479.1 - 0.00047 20.6 0.0 0.0099 16.3 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Peptidase_C1_2 PF03051.10 EWC45480.1 - 4.2e-145 483.6 0.1 5.2e-145 483.3 0.1 1.0 1 0 0 1 1 1 1 Peptidase C1-like family Peptidase_C1 PF00112.18 EWC45480.1 - 0.0012 18.7 2.7 0.0031 17.4 1.9 1.7 1 1 0 1 1 1 1 Papain family cysteine protease zf-C2H2_4 PF13894.1 EWC45482.1 - 0.056 13.7 0.2 0.3 11.4 0.0 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger PQ-loop PF04193.9 EWC45483.1 - 9.5e-22 76.3 15.6 1.6e-12 46.7 0.9 2.9 3 0 0 3 3 3 2 PQ loop repeat DUF3796 PF12676.2 EWC45483.1 - 0.0014 18.8 0.2 0.0031 17.7 0.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3796) DUF4271 PF14093.1 EWC45483.1 - 0.026 14.1 8.2 2.6 7.6 0.0 3.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4271) Rib_5-P_isom_A PF06026.9 EWC45484.1 - 5.4e-44 149.5 0.0 7.2e-44 149.1 0.0 1.1 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) DeoRC PF00455.17 EWC45484.1 - 0.071 12.7 0.0 6.5 6.3 0.0 2.2 2 0 0 2 2 2 0 DeoR C terminal sensor domain ThiF PF00899.16 EWC45485.1 - 4.3e-08 33.0 0.0 9e-08 32.0 0.0 1.5 1 0 0 1 1 1 1 ThiF family XAP5 PF04921.9 EWC45487.1 - 1.6e-70 237.4 0.0 2.8e-70 236.6 0.0 1.4 2 0 0 2 2 2 1 XAP5, circadian clock regulator Radical_SAM PF04055.16 EWC45488.1 - 2.9e-25 89.3 0.0 1.1e-24 87.4 0.0 2.0 2 1 0 2 2 2 1 Radical SAM superfamily Wyosine_form PF08608.7 EWC45488.1 - 5.1e-24 84.1 0.0 1.4e-23 82.7 0.0 1.9 1 0 0 1 1 1 1 Wyosine base formation Flavodoxin_1 PF00258.20 EWC45488.1 - 4.2e-13 49.5 0.1 4.1e-08 33.3 0.0 3.0 3 0 0 3 3 3 2 Flavodoxin Flavodoxin_5 PF12724.2 EWC45488.1 - 0.03 14.3 0.0 0.081 12.9 0.0 1.7 1 0 0 1 1 1 0 Flavodoxin domain F-box-like PF12937.2 EWC45490.1 - 1.5e-07 31.0 0.0 3.1e-07 29.9 0.0 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EWC45490.1 - 2.5e-07 30.1 0.0 7.5e-07 28.6 0.0 1.8 1 0 0 1 1 1 1 F-box domain SNF2_N PF00176.18 EWC45491.1 - 4.4e-58 196.4 0.0 2.1e-57 194.2 0.0 2.0 1 1 0 1 1 1 1 SNF2 family N-terminal domain HDA2-3 PF11496.3 EWC45491.1 - 9.7e-12 44.3 0.4 1.1e-10 40.7 0.3 2.3 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 Helicase_C PF00271.26 EWC45491.1 - 2.7e-10 39.9 0.3 1e-09 38.0 0.0 2.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain PHD PF00628.24 EWC45491.1 - 0.1 12.2 28.7 0.053 13.2 13.5 3.0 2 1 1 3 3 3 0 PHD-finger adh_short PF00106.20 EWC45492.1 - 5.2e-14 52.4 0.0 9.9e-14 51.5 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EWC45492.1 - 0.00011 21.8 0.0 0.00018 21.2 0.0 1.3 1 0 0 1 1 1 1 KR domain UPF0261 PF06792.6 EWC45494.1 - 8.1e-128 426.3 0.0 9.7e-128 426.0 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0261) UDPGT PF00201.13 EWC45495.1 - 1.7e-13 49.9 0.0 2.3e-13 49.5 0.0 1.1 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.11 EWC45495.1 - 0.0002 21.0 0.0 0.00032 20.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_transf_28 PF03033.15 EWC45495.1 - 0.014 15.1 0.0 0.026 14.2 0.0 1.5 1 0 0 1 1 1 0 Glycosyltransferase family 28 N-terminal domain Glyco_trans_1_3 PF13528.1 EWC45495.1 - 0.056 12.6 0.0 0.088 11.9 0.0 1.2 1 0 0 1 1 1 0 Glycosyl transferase family 1 LamB PF02264.10 EWC45498.1 - 0.029 13.4 0.0 0.04 13.0 0.0 1.1 1 0 0 1 1 1 0 LamB porin Acyl_transf_3 PF01757.17 EWC45499.1 - 3.5e-28 98.4 26.7 5.3e-28 97.8 18.5 1.3 1 0 0 1 1 1 1 Acyltransferase family HNH PF01844.18 EWC45500.1 - 0.042 13.7 1.1 0.27 11.1 0.0 2.2 1 1 1 2 2 2 0 HNH endonuclease DUF1396 PF07161.8 EWC45500.1 - 0.069 12.8 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1396) AAA_16 PF13191.1 EWC45501.1 - 0.00048 20.1 0.0 0.0012 18.9 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain Abhydrolase_6 PF12697.2 EWC45501.1 - 0.001 19.0 0.1 0.029 14.2 0.0 2.6 2 0 0 2 2 2 1 Alpha/beta hydrolase family DUF676 PF05057.9 EWC45501.1 - 0.0015 17.8 0.0 0.0026 17.0 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) AAA_22 PF13401.1 EWC45501.1 - 0.0042 17.2 0.0 0.01 16.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain PGAP1 PF07819.8 EWC45501.1 - 0.012 15.1 0.0 0.025 14.1 0.0 1.4 1 0 0 1 1 1 0 PGAP1-like protein Arch_ATPase PF01637.13 EWC45501.1 - 0.12 12.0 0.0 0.23 11.1 0.0 1.3 1 0 0 1 1 1 0 Archaeal ATPase PGM_PMM_I PF02878.11 EWC45505.1 - 2.4e-33 114.5 0.1 4.2e-32 110.5 0.0 2.4 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.11 EWC45505.1 - 2.5e-22 79.1 0.1 6.2e-22 77.8 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.11 EWC45505.1 - 4.4e-12 46.0 0.4 1.2e-11 44.6 0.1 2.0 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.15 EWC45505.1 - 1.4e-09 37.8 0.0 5.9e-09 35.8 0.0 2.1 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain ECH PF00378.15 EWC45506.1 - 3.7e-52 176.8 0.1 4.5e-52 176.6 0.1 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family zf-C2H2_jaz PF12171.3 EWC45507.1 - 0.00094 19.2 8.3 0.36 11.0 0.1 4.1 3 1 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-met2 PF12907.2 EWC45507.1 - 0.014 15.3 0.0 0.014 15.3 0.0 3.4 4 0 0 4 4 4 0 Zinc-binding zf-Di19 PF05605.7 EWC45507.1 - 0.049 13.7 12.9 0.34 11.0 0.6 3.6 3 1 1 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding zf-met PF12874.2 EWC45507.1 - 0.069 13.3 0.1 0.069 13.3 0.1 5.2 6 0 0 6 6 6 0 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.1 EWC45507.1 - 0.094 12.6 0.3 0.094 12.6 0.2 4.9 5 0 0 5 5 5 0 C2H2-type zinc finger DUF1828 PF08861.5 EWC45507.1 - 0.13 11.9 0.0 0.77 9.4 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function DUF1828 zf-C2H2_4 PF13894.1 EWC45507.1 - 0.25 11.7 23.8 4.2 7.9 0.4 5.8 5 0 0 5 5 5 0 C2H2-type zinc finger zf-C2H2_2 PF12756.2 EWC45507.1 - 2.5 8.2 16.0 1.6 8.9 0.1 4.1 4 1 1 5 5 5 0 C2H2 type zinc-finger (2 copies) Glyco_transf_90 PF05686.7 EWC45508.1 - 2e-16 59.6 0.3 1.4e-13 50.2 0.1 2.2 2 0 0 2 2 2 2 Glycosyl transferase family 90 RrnaAD PF00398.15 EWC45509.1 - 4.5e-14 52.1 0.0 9.8e-14 51.0 0.0 1.5 1 1 0 1 1 1 1 Ribosomal RNA adenine dimethylase LCM PF04072.9 EWC45510.1 - 1.4e-31 109.5 0.0 2e-31 108.9 0.0 1.2 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase DUF2013 PF09431.5 EWC45511.1 - 1e-47 161.4 1.4 1e-47 161.4 1.0 2.5 2 1 0 2 2 2 1 Protein of unknown function (DUF2013) MutS_V PF00488.16 EWC45512.1 - 3.9e-95 317.7 0.1 7.5e-95 316.8 0.1 1.5 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.13 EWC45512.1 - 5.6e-36 124.2 0.7 1.1e-35 123.3 0.5 1.5 1 0 0 1 1 1 1 MutS domain III MutS_II PF05188.12 EWC45512.1 - 6.4e-22 78.0 0.1 6.4e-22 78.0 0.0 2.4 3 0 0 3 3 3 1 MutS domain II MutS_IV PF05190.13 EWC45512.1 - 4.8e-19 68.3 0.9 4.8e-19 68.3 0.6 2.2 2 0 0 2 2 2 1 MutS family domain IV MutS_I PF01624.15 EWC45512.1 - 1.4e-18 66.9 0.0 6.3e-18 64.8 0.0 2.1 2 0 0 2 2 2 1 MutS domain I eIF2A PF08662.6 EWC45513.1 - 3.2e-79 265.1 0.7 3.6e-77 258.4 0.0 2.9 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A WD40 PF00400.27 EWC45513.1 - 0.00051 19.8 1.2 0.97 9.4 0.1 4.7 5 0 0 5 5 5 1 WD domain, G-beta repeat PD40 PF07676.7 EWC45513.1 - 0.0022 17.6 1.9 0.79 9.4 0.0 3.5 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat CDV3 PF15359.1 EWC45513.1 - 0.027 14.5 0.4 0.027 14.5 0.3 3.4 4 0 0 4 4 4 0 Carnitine deficiency-associated protein 3 Proteasome_A_N PF10584.4 EWC45513.1 - 0.035 13.4 1.2 12 5.3 0.0 3.8 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature JAB PF01398.16 EWC45514.1 - 7.2e-17 61.1 0.0 1.9e-16 59.8 0.0 1.7 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease USP8_dimer PF08969.6 EWC45514.1 - 2.2e-10 40.5 0.2 4.4e-10 39.5 0.2 1.5 1 0 0 1 1 1 1 USP8 dimerisation domain Prok-JAB PF14464.1 EWC45514.1 - 1.4e-05 24.6 0.0 4.9e-05 22.8 0.0 2.0 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain Prenylcys_lyase PF07156.9 EWC45515.1 - 1.3e-38 132.8 0.0 2.2e-38 132.1 0.0 1.2 1 0 0 1 1 1 1 Prenylcysteine lyase NAD_binding_8 PF13450.1 EWC45515.1 - 7e-11 41.9 0.0 2e-10 40.5 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 EWC45515.1 - 3.5e-06 26.1 0.0 2.8e-05 23.2 0.0 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 EWC45515.1 - 1.2e-05 25.4 0.0 0.15 12.1 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 EWC45515.1 - 1.5e-05 24.8 0.0 0.0024 17.6 0.0 2.3 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.9 EWC45515.1 - 8.3e-05 22.5 0.1 0.16 11.8 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.19 EWC45515.1 - 0.00049 19.2 0.0 0.022 13.8 0.0 2.2 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase Thi4 PF01946.12 EWC45515.1 - 0.0015 17.6 0.4 0.3 10.1 0.0 2.2 2 0 0 2 2 2 2 Thi4 family Pyr_redox PF00070.22 EWC45515.1 - 0.051 13.9 0.4 0.3 11.4 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 EWC45515.1 - 0.11 11.4 0.0 12 4.6 0.0 2.1 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) RTC4 PF14474.1 EWC45516.1 - 9.2e-20 70.8 0.0 1.9e-19 69.8 0.0 1.5 1 0 0 1 1 1 1 RTC4-like domain Peroxin-13_N PF04088.8 EWC45517.1 - 1.2e-56 191.0 0.0 1.7e-56 190.5 0.0 1.2 1 0 0 1 1 1 1 Peroxin 13, N-terminal region SH3_1 PF00018.23 EWC45517.1 - 2.4e-08 33.2 0.0 4e-08 32.5 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 EWC45517.1 - 4.9e-07 29.2 0.1 7.8e-07 28.5 0.1 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 EWC45517.1 - 1.1e-06 28.0 0.0 2.4e-06 26.9 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Cmc1 PF08583.5 EWC45518.1 - 3.1e-13 49.2 2.9 3.7e-13 49.0 2.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like ATP-synt_B PF00430.13 EWC45518.1 - 0.055 13.2 1.2 0.062 13.0 0.8 1.1 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) Ribonuclease_P PF00825.13 EWC45518.1 - 0.058 13.2 0.2 0.067 13.1 0.1 1.1 1 0 0 1 1 1 0 Ribonuclease P Prefoldin_2 PF01920.15 EWC45519.1 - 9.4e-25 86.4 0.6 1.1e-24 86.2 0.4 1.1 1 0 0 1 1 1 1 Prefoldin subunit DUF2205 PF10224.4 EWC45519.1 - 0.0013 18.2 2.2 0.067 12.7 0.3 2.1 2 0 0 2 2 2 1 Predicted coiled-coil protein (DUF2205) MAGSP PF03082.9 EWC45519.1 - 0.0035 16.7 0.3 0.0046 16.3 0.2 1.2 1 0 0 1 1 1 1 Male accessory gland secretory protein IncA PF04156.9 EWC45519.1 - 0.0057 16.2 0.2 0.0069 16.0 0.1 1.2 1 0 0 1 1 1 1 IncA protein Filament PF00038.16 EWC45519.1 - 0.007 15.8 2.0 0.019 14.4 0.7 1.7 1 1 1 2 2 2 1 Intermediate filament protein Syntaxin-6_N PF09177.6 EWC45519.1 - 0.0098 16.2 1.0 0.069 13.5 0.5 1.9 1 1 0 2 2 2 1 Syntaxin 6, N-terminal ATG16 PF08614.6 EWC45519.1 - 0.018 14.8 1.9 2.5 7.9 0.7 2.1 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) TMF_DNA_bd PF12329.3 EWC45519.1 - 0.027 14.2 2.7 0.86 9.4 1.9 2.1 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding NAD_binding_4 PF07993.7 EWC45519.1 - 0.055 12.3 0.1 0.07 12.0 0.1 1.1 1 0 0 1 1 1 0 Male sterility protein Tropomyosin PF00261.15 EWC45519.1 - 0.067 12.2 1.9 3.8 6.5 0.5 2.1 2 0 0 2 2 2 0 Tropomyosin bZIP_Maf PF03131.12 EWC45519.1 - 0.11 12.7 3.1 11 6.3 1.7 2.1 2 0 0 2 2 2 0 bZIP Maf transcription factor Mnd1 PF03962.10 EWC45519.1 - 0.12 11.9 1.4 0.23 11.1 1.0 1.5 1 1 0 1 1 1 0 Mnd1 family Tho2 PF11262.3 EWC45519.1 - 0.12 11.3 0.2 5.7 5.9 0.8 1.9 1 1 1 2 2 2 0 Transcription factor/nuclear export subunit protein 2 OmpH PF03938.9 EWC45519.1 - 0.16 11.8 5.2 0.13 12.1 2.4 1.7 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Cytochrom_B562 PF07361.6 EWC45519.1 - 0.19 12.1 2.3 0.4 11.1 0.7 1.9 2 0 0 2 2 2 0 Cytochrome b562 Prefoldin PF02996.12 EWC45519.1 - 0.24 11.0 2.6 3.3 7.3 1.8 2.0 1 1 0 1 1 1 0 Prefoldin subunit Occludin_ELL PF07303.8 EWC45519.1 - 0.67 10.7 3.4 7.9 7.2 1.0 2.1 1 1 0 2 2 2 0 Occludin homology domain CBFD_NFYB_HMF PF00808.18 EWC45520.1 - 3.1e-30 104.0 0.9 4.2e-30 103.6 0.6 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 EWC45520.1 - 1.2e-07 31.7 0.0 1.8e-07 31.1 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID-18kDa PF02269.11 EWC45520.1 - 0.00026 20.7 0.0 0.00043 20.0 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit Bromo_TP PF07524.8 EWC45520.1 - 0.00049 19.7 0.1 0.00074 19.2 0.0 1.3 1 0 0 1 1 1 1 Bromodomain associated TFIID_20kDa PF03847.8 EWC45520.1 - 0.0084 16.3 0.1 0.032 14.5 0.0 1.8 2 0 0 2 2 2 1 Transcription initiation factor TFIID subunit A PAN_3 PF08277.7 EWC45520.1 - 0.086 12.4 0.1 0.13 11.9 0.1 1.3 1 0 0 1 1 1 0 PAN-like domain PAN_2 PF08276.6 EWC45520.1 - 0.13 12.0 0.5 0.25 11.2 0.0 1.7 2 0 0 2 2 2 0 PAN-like domain DUF3716 PF12511.3 EWC45521.1 - 0.049 13.2 2.7 0.11 12.0 1.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3716) Peptidase_C14 PF00656.17 EWC45522.1 - 3.7e-70 236.4 0.1 4.6e-70 236.1 0.0 1.1 1 0 0 1 1 1 1 Caspase domain SSURE PF11966.3 EWC45522.1 - 0.025 14.1 0.1 0.051 13.1 0.0 1.4 1 0 0 1 1 1 0 Fibronectin-binding repeat PAT1 PF09770.4 EWC45522.1 - 3.8 5.6 27.7 5.3 5.1 19.2 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 FA_desaturase PF00487.19 EWC45523.1 - 9.2e-36 123.5 18.9 1.3e-35 123.0 13.1 1.2 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.23 EWC45523.1 - 7.9e-13 48.0 0.0 1.5e-12 47.1 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain AtpR PF12966.2 EWC45523.1 - 0.038 14.1 0.1 0.092 12.8 0.1 1.6 1 0 0 1 1 1 0 N-ATPase, AtpR subunit Adeno_E3B PF03376.9 EWC45524.1 - 0.0095 15.8 1.3 0.047 13.6 0.9 2.2 1 0 0 1 1 1 1 Adenovirus E3B protein TPR_1 PF00515.23 EWC45525.1 - 1e-11 43.9 0.5 3.2e-07 29.6 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 EWC45525.1 - 1.1e-09 37.4 0.6 5.7e-05 22.7 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.1 EWC45525.1 - 3.6e-09 36.1 2.0 1.3e-08 34.3 0.1 2.6 3 0 0 3 3 3 1 TPR repeat TPR_12 PF13424.1 EWC45525.1 - 1.2e-05 25.1 0.4 0.00095 19.0 0.0 2.4 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.1 EWC45525.1 - 2e-05 24.0 0.1 9.9e-05 21.8 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.1 EWC45525.1 - 2.8e-05 23.5 0.1 0.00035 20.1 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.1 EWC45525.1 - 0.00015 21.6 0.1 1.2 9.4 0.0 2.9 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_6 PF13174.1 EWC45525.1 - 0.0029 17.9 0.0 1.4 9.5 0.0 3.3 4 0 0 4 4 3 1 Tetratricopeptide repeat PB1 PF00564.19 EWC45525.1 - 0.005 16.4 0.1 0.0091 15.6 0.0 1.5 1 0 0 1 1 1 1 PB1 domain TPR_14 PF13428.1 EWC45525.1 - 0.012 16.1 0.0 0.048 14.2 0.0 2.1 2 0 0 2 2 1 0 Tetratricopeptide repeat TPR_16 PF13432.1 EWC45525.1 - 0.014 16.0 0.4 0.4 11.4 0.0 2.0 1 1 1 2 2 2 0 Tetratricopeptide repeat DUF3808 PF10300.4 EWC45525.1 - 0.069 11.7 0.0 0.13 10.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3808) DUF1500 PF07389.7 EWC45525.1 - 0.098 12.6 1.2 0.21 11.6 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1500) RPN7 PF10602.4 EWC45525.1 - 0.14 11.4 0.2 16 4.8 0.0 2.3 2 0 0 2 2 2 0 26S proteasome subunit RPN7 Aconitase PF00330.15 EWC45527.1 - 1.1e-52 179.0 0.5 1.9e-47 161.8 0.0 2.2 1 1 1 2 2 2 2 Aconitase family (aconitate hydratase) Aconitase_C PF00694.14 EWC45527.1 - 3.1e-22 79.0 0.0 5.7e-22 78.2 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain Lipoxygenase PF00305.14 EWC45528.1 - 4.5e-35 120.7 0.0 6e-35 120.3 0.0 1.2 1 0 0 1 1 1 1 Lipoxygenase PDCD2_C PF04194.8 EWC45529.1 - 4e-41 140.3 0.0 6.4e-41 139.6 0.0 1.2 1 0 0 1 1 1 1 Programmed cell death protein 2, C-terminal putative domain Glyco_transf_22 PF03901.12 EWC45530.1 - 2.1e-36 125.8 9.4 2.7e-36 125.4 6.5 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family RseC_MucC PF04246.7 EWC45530.1 - 1.5 8.3 8.3 1.1 8.7 1.7 2.7 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC Yos1 PF08571.5 EWC45531.1 - 8e-08 32.2 0.0 9.2e-08 32.0 0.0 1.0 1 0 0 1 1 1 1 Yos1-like CBS PF00571.23 EWC45532.1 - 0.014 15.1 0.1 1.2 9.0 0.1 2.8 1 1 1 2 2 2 0 CBS domain Aminotran_1_2 PF00155.16 EWC45534.1 - 3.4e-15 55.8 0.0 4.6e-15 55.4 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Epimerase PF01370.16 EWC45536.1 - 7.7e-20 71.3 0.0 1.1e-19 70.8 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 EWC45536.1 - 1.6e-09 37.0 0.0 3e-09 36.1 0.0 1.3 1 1 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.14 EWC45536.1 - 1.8e-05 23.5 0.0 3.1e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short PF00106.20 EWC45536.1 - 0.0018 18.2 0.0 0.0069 16.3 0.0 1.9 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.5 EWC45536.1 - 0.11 12.1 0.0 0.5 10.0 0.0 1.9 2 0 0 2 2 2 0 KR domain Semialdhyde_dh PF01118.19 EWC45536.1 - 0.11 12.7 0.0 0.41 10.9 0.0 2.0 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain DUF3884 PF13024.1 EWC45537.1 - 0.059 12.7 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3884) DUF2417 PF10329.4 EWC45538.1 - 4.7e-70 235.6 0.7 5.9e-70 235.2 0.5 1.1 1 0 0 1 1 1 1 Region of unknown function (DUF2417) Abhydrolase_6 PF12697.2 EWC45538.1 - 1.9e-11 44.2 0.3 4e-11 43.2 0.2 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EWC45538.1 - 0.015 15.0 0.1 0.034 13.8 0.1 1.6 1 0 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EWC45538.1 - 0.072 12.6 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold E1-E2_ATPase PF00122.15 EWC45538.1 - 0.14 11.2 1.4 1.2 8.0 0.2 2.2 2 0 0 2 2 2 0 E1-E2 ATPase DUF2269 PF10027.4 EWC45538.1 - 0.41 10.4 14.1 0.026 14.3 1.2 2.6 1 1 1 2 2 2 0 Predicted integral membrane protein (DUF2269) DUF3357 PF11837.3 EWC45538.1 - 1.4 8.7 0.0 1.4 8.7 0.0 3.0 2 1 0 3 3 3 0 Domain of unknown function (DUF3357) Exo_endo_phos PF03372.18 EWC45539.1 - 5.2e-11 42.9 0.0 6.8e-11 42.5 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF3995 PF13160.1 EWC45539.1 - 0.058 13.4 0.1 0.19 11.8 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3995) UCH PF00443.24 EWC45540.1 - 6e-69 232.1 0.0 9.8e-69 231.4 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 EWC45540.1 - 2.7e-31 109.1 1.0 7.6e-23 81.3 0.0 2.4 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Sec20 PF03908.8 EWC45541.1 - 6.2e-15 54.6 0.0 1.6e-14 53.3 0.0 1.7 1 0 0 1 1 1 1 Sec20 Cep57_MT_bd PF06657.8 EWC45541.1 - 0.065 13.1 0.9 0.21 11.5 0.0 2.4 3 0 0 3 3 3 0 Centrosome microtubule-binding domain of Cep57 Pyrophosphatase PF00719.14 EWC45542.1 - 3.7e-51 172.6 0.1 4.7e-51 172.3 0.1 1.1 1 0 0 1 1 1 1 Inorganic pyrophosphatase ABC_tran PF00005.22 EWC45544.1 - 7.6e-34 116.9 0.0 2e-33 115.6 0.0 1.7 2 0 0 2 2 1 1 ABC transporter ABC_membrane PF00664.18 EWC45544.1 - 7.2e-33 114.1 13.7 1.1e-32 113.6 9.5 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region AAA_21 PF13304.1 EWC45544.1 - 1.7e-05 24.9 0.0 0.017 15.0 0.0 2.2 1 1 1 2 2 2 2 AAA domain SMC_N PF02463.14 EWC45544.1 - 2.3e-05 23.7 0.3 0.0013 18.0 0.0 2.2 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_17 PF13207.1 EWC45544.1 - 0.00016 22.4 0.0 0.00036 21.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA PF00004.24 EWC45544.1 - 0.00042 20.5 0.0 0.014 15.5 0.0 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 EWC45544.1 - 0.00089 19.2 0.0 0.0082 16.1 0.0 2.4 2 1 0 2 2 2 1 AAA ATPase domain DUF258 PF03193.11 EWC45544.1 - 0.0028 16.8 0.0 0.0058 15.8 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_22 PF13401.1 EWC45544.1 - 0.0031 17.6 0.1 0.043 13.9 0.0 2.5 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 EWC45544.1 - 0.0065 16.7 0.0 0.019 15.2 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.1 EWC45544.1 - 0.0077 15.6 0.0 0.027 13.8 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.1 EWC45544.1 - 0.0091 15.5 0.0 0.034 13.6 0.0 2.0 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_14 PF13173.1 EWC45544.1 - 0.013 15.3 0.0 0.093 12.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain SbcCD_C PF13558.1 EWC45544.1 - 0.045 13.6 0.8 0.55 10.1 0.5 2.5 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_28 PF13521.1 EWC45544.1 - 0.05 13.5 0.0 0.11 12.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.1 EWC45544.1 - 0.06 13.2 0.0 0.18 11.6 0.0 1.9 1 0 0 1 1 1 0 AAA domain ATP-synt_ab PF00006.20 EWC45544.1 - 0.068 12.6 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_23 PF13476.1 EWC45544.1 - 0.19 12.0 0.0 0.39 11.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain DIOX_N PF14226.1 EWC45545.1 - 1.8e-21 76.8 0.3 1.4e-20 73.9 0.2 2.1 1 1 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.15 EWC45545.1 - 1.5e-13 50.8 0.0 2.3e-13 50.2 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily NAD_binding_10 PF13460.1 EWC45546.1 - 4.7e-10 39.7 0.0 7.2e-10 39.1 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 EWC45546.1 - 6.8e-08 32.2 0.2 2.9e-07 30.1 0.1 2.2 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 EWC45546.1 - 3.3e-07 29.3 0.0 4.3e-06 25.6 0.0 2.1 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.12 EWC45546.1 - 1.2e-05 24.3 0.1 0.0001 21.3 0.0 2.1 1 1 0 1 1 1 1 RmlD substrate binding domain NmrA PF05368.8 EWC45546.1 - 0.00016 21.0 0.0 0.00027 20.2 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family NAD_binding_4 PF07993.7 EWC45546.1 - 0.012 14.4 0.1 0.074 11.9 0.0 1.8 1 1 1 2 2 2 0 Male sterility protein PCI PF01399.22 EWC45548.1 - 2.7e-09 37.2 0.0 6.3e-09 36.0 0.0 1.7 1 0 0 1 1 1 1 PCI domain DnaJ PF00226.26 EWC45549.1 - 1.6e-07 30.9 0.1 3e-07 30.0 0.1 1.5 1 0 0 1 1 1 1 DnaJ domain Avl9 PF09794.4 EWC45550.1 - 0.0011 17.5 0.1 0.0088 14.5 0.0 2.0 2 0 0 2 2 2 1 Transport protein Avl9 SPA PF08616.5 EWC45550.1 - 0.0012 18.5 0.1 0.0029 17.2 0.1 1.6 1 0 0 1 1 1 1 Stabilization of polarity axis Vac14_Fig4_bd PF11916.3 EWC45551.1 - 1.6e-78 262.0 5.2 3e-78 261.1 3.6 1.5 1 0 0 1 1 1 1 Vacuolar protein 14 C-terminal Fig4p binding Vac14_Fab1_bd PF12755.2 EWC45551.1 - 2.1e-45 153.0 0.2 1.2e-42 144.2 0.0 3.6 3 0 0 3 3 3 1 Vacuolar 14 Fab1-binding region HEAT PF02985.17 EWC45551.1 - 8.9e-09 34.7 1.7 0.00018 21.3 0.0 6.3 6 0 0 6 6 6 1 HEAT repeat HEAT_2 PF13646.1 EWC45551.1 - 1.8e-06 28.0 3.2 0.0061 16.8 0.0 4.2 4 1 0 4 4 4 2 HEAT repeats HEAT_EZ PF13513.1 EWC45551.1 - 9.8e-06 25.9 0.6 0.042 14.3 0.0 5.8 6 0 0 6 6 6 1 HEAT-like repeat Cnd1 PF12717.2 EWC45551.1 - 0.011 15.5 1.0 3.6 7.3 0.1 2.9 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 Arm PF00514.18 EWC45551.1 - 0.06 13.1 0.0 23 4.9 0.0 3.8 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat DUF367 PF04034.8 EWC45552.1 - 2e-51 172.8 0.1 6e-51 171.3 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF367) GTP_EFTU PF00009.22 EWC45552.1 - 3.3e-38 131.0 1.2 1.5e-37 128.8 0.8 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.3 EWC45552.1 - 2.9e-22 78.6 0.3 7.1e-22 77.3 0.2 1.6 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.20 EWC45552.1 - 2.2e-14 53.2 2.8 2.2e-08 34.0 0.1 2.7 2 0 0 2 2 2 2 Elongation factor Tu domain 2 RLI PF04068.10 EWC45552.1 - 2.8e-13 49.2 1.2 2.8e-13 49.2 0.8 2.1 3 0 0 3 3 3 1 Possible Fer4-like domain in RNase L inhibitor, RLI MMR_HSR1 PF01926.18 EWC45552.1 - 4.1e-07 29.9 0.1 1e-06 28.7 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 EWC45552.1 - 2.8e-06 27.8 0.1 1.4e-05 25.6 0.0 2.2 2 0 0 2 2 2 1 Miro-like protein Arf PF00025.16 EWC45552.1 - 0.0002 20.6 0.0 0.00039 19.7 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.17 EWC45552.1 - 0.00033 20.0 0.0 0.00062 19.1 0.0 1.4 1 0 0 1 1 1 1 Ras family SRPRB PF09439.5 EWC45552.1 - 0.00082 18.6 0.0 0.00082 18.6 0.0 2.0 2 1 0 2 2 2 1 Signal recognition particle receptor beta subunit IF2_N PF04760.10 EWC45552.1 - 0.0017 17.9 0.0 0.0044 16.6 0.0 1.8 1 0 0 1 1 1 1 Translation initiation factor IF-2, N-terminal region PduV-EutP PF10662.4 EWC45552.1 - 0.052 13.0 0.1 0.14 11.6 0.0 1.7 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Dynamin_N PF00350.18 EWC45552.1 - 0.076 12.8 1.9 1.6 8.4 0.1 3.4 2 1 1 3 3 3 0 Dynamin family ATP_bind_1 PF03029.12 EWC45552.1 - 0.15 11.5 0.0 0.32 10.4 0.0 1.5 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein S4_2 PF13275.1 EWC45552.1 - 0.55 9.8 3.6 0.44 10.1 0.4 2.3 2 0 0 2 2 2 0 S4 domain VHS PF00790.14 EWC45553.1 - 2.3e-44 150.4 0.0 1.2e-43 148.1 0.0 2.0 2 0 0 2 2 2 1 VHS domain GAT PF03127.9 EWC45553.1 - 1.5e-20 73.0 1.1 4.3e-20 71.5 0.8 1.8 1 0 0 1 1 1 1 GAT domain Alpha_adaptinC2 PF02883.15 EWC45553.1 - 5.5e-14 52.4 0.0 1.9e-13 50.7 0.0 2.0 1 0 0 1 1 1 1 Adaptin C-terminal domain TroA PF01297.12 EWC45553.1 - 0.044 13.0 1.3 0.085 12.0 0.9 1.4 1 0 0 1 1 1 0 Periplasmic solute binding protein family Na_H_Exchanger PF00999.16 EWC45554.1 - 1.1e-64 218.3 53.4 1.1e-64 218.3 37.0 1.5 2 0 0 2 2 2 1 Sodium/hydrogen exchanger family Glyco_hydro_18 PF00704.23 EWC45555.1 - 1.8e-86 290.7 0.8 2.1e-86 290.4 0.2 1.3 2 0 0 2 2 2 1 Glycosyl hydrolases family 18 AIM24 PF01987.12 EWC45556.1 - 4.7e-37 127.5 0.0 7.3e-37 126.9 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial biogenesis AIM24 UCH PF00443.24 EWC45557.1 - 1e-34 119.9 0.1 1.7e-34 119.1 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 EWC45557.1 - 1.1e-15 57.9 0.1 2.4e-15 56.7 0.0 1.5 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.14 EWC45557.1 - 1.3e-07 31.6 13.8 1.3e-07 31.6 9.5 3.4 4 0 0 4 4 4 1 Zn-finger in ubiquitin-hydrolases and other protein YvrJ PF12841.2 EWC45557.1 - 0.26 10.6 0.4 7.3 5.9 0.1 2.5 2 0 0 2 2 2 0 YvrJ protein family Paired_CXXCH_1 PF09699.5 EWC45557.1 - 0.88 9.1 12.8 2.3 7.8 0.0 3.1 2 0 0 2 2 2 0 Doubled CXXCH motif (Paired_CXXCH_1) Y_phosphatase PF00102.22 EWC45558.1 - 3.3e-52 177.1 0.0 4.7e-52 176.6 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.1 EWC45558.1 - 0.00065 19.7 0.0 0.0012 18.8 0.0 1.4 1 0 0 1 1 1 1 Inositol hexakisphosphate DSPc PF00782.15 EWC45558.1 - 0.0044 16.5 0.0 0.0098 15.4 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Dpy19 PF10034.4 EWC45558.1 - 0.029 12.5 0.0 0.038 12.1 0.0 1.1 1 0 0 1 1 1 0 Q-cell neuroblast polarisation Y_phosphatase3 PF13350.1 EWC45558.1 - 0.032 14.4 0.0 0.065 13.4 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family UNC-50 PF05216.8 EWC45559.1 - 3.7e-76 255.3 11.5 4.5e-76 255.0 8.0 1.0 1 0 0 1 1 1 1 UNC-50 family DUF2697 PF10906.3 EWC45560.1 - 3.8e-05 23.6 0.1 6e-05 22.9 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF2697) DUF624 PF04854.9 EWC45560.1 - 0.054 13.3 0.0 0.078 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF624 zf-RING_2 PF13639.1 EWC45561.1 - 7.8e-08 32.0 8.5 1.2e-07 31.4 5.9 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.1 EWC45561.1 - 1.1e-05 24.9 6.6 1.7e-05 24.3 4.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 EWC45561.1 - 0.00049 19.8 2.4 0.00093 18.9 1.7 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.2 EWC45561.1 - 0.0046 17.0 3.2 0.0092 16.0 2.2 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_5 PF14634.1 EWC45561.1 - 1 9.1 7.5 1.7 8.4 5.2 1.3 1 0 0 1 1 1 0 zinc-RING finger domain DUF2685 PF10886.3 EWC45561.1 - 4.2 7.4 6.2 3.2 7.8 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2685) SMC_N PF02463.14 EWC45562.1 - 3.9e-79 264.9 0.0 8.8e-79 263.7 0.0 1.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.8 EWC45562.1 - 4e-26 91.3 0.0 1.6e-25 89.4 0.0 2.1 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.1 EWC45562.1 - 8.6e-14 52.1 1.0 1.3e-05 25.3 0.0 2.8 3 0 0 3 3 3 2 AAA domain AAA_29 PF13555.1 EWC45562.1 - 6.2e-05 22.4 0.0 0.00012 21.4 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain DivIC PF04977.10 EWC45562.1 - 0.007 15.8 0.5 0.007 15.8 0.3 11.3 7 3 6 13 13 13 2 Septum formation initiator Reo_sigmaC PF04582.7 EWC45562.1 - 0.11 11.7 16.1 0.68 9.0 0.1 4.6 2 2 1 4 4 4 0 Reovirus sigma C capsid protein ABC_tran PF00005.22 EWC45562.1 - 1.1 9.5 0.0 1.1 9.5 0.0 6.0 3 2 1 4 4 4 0 ABC transporter N6-adenineMlase PF10237.4 EWC45563.1 - 8e-36 123.1 0.0 1.1e-35 122.7 0.0 1.2 1 0 0 1 1 1 1 Probable N6-adenine methyltransferase Ytp1 PF10355.4 EWC45564.1 - 8.5e-97 323.5 13.0 1.4e-96 322.8 9.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (Ytp1) DUF2427 PF10348.4 EWC45564.1 - 2e-26 91.5 5.9 2e-26 91.5 4.1 2.8 3 0 0 3 3 3 1 Domain of unknown function (DUF2427) Fungal_trans_2 PF11951.3 EWC45565.1 - 2.5e-17 62.5 0.0 1.8e-16 59.7 0.0 2.0 1 1 0 1 1 1 1 Fungal specific transcription factor domain BSP_II PF05432.6 EWC45565.1 - 0.008 15.4 5.7 0.017 14.3 3.9 1.5 1 0 0 1 1 1 1 Bone sialoprotein II (BSP-II) DUF2890 PF11081.3 EWC45565.1 - 8.1 6.4 10.6 1.4 8.9 4.7 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2890) OTU PF02338.14 EWC45567.1 - 8.7e-10 39.2 0.0 1.5e-09 38.4 0.0 1.4 1 0 0 1 1 1 1 OTU-like cysteine protease Glyco_hydro_85 PF03644.8 EWC45568.1 - 3.7e-85 285.7 0.0 5e-85 285.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 85 DASH_Dam1 PF08653.5 EWC45568.1 - 4.8e-23 80.6 1.4 9e-23 79.8 1.0 1.5 1 0 0 1 1 1 1 DASH complex subunit Dam1 FAD_binding_4 PF01565.18 EWC45569.1 - 8e-27 93.4 2.9 8e-27 93.4 2.0 1.7 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.7 EWC45569.1 - 0.0047 16.8 0.0 0.0095 15.8 0.0 1.4 1 0 0 1 1 1 1 Berberine and berberine like Sec7 PF01369.15 EWC45570.1 - 4.7e-36 124.2 0.0 1.1e-35 123.0 0.0 1.5 1 0 0 1 1 1 1 Sec7 domain PH_9 PF15410.1 EWC45570.1 - 7e-23 81.0 0.0 2e-22 79.5 0.0 1.9 2 0 0 2 2 2 1 Pleckstrin homology domain PH PF00169.24 EWC45570.1 - 0.0025 17.9 0.0 0.0057 16.8 0.0 1.6 1 0 0 1 1 1 1 PH domain DUF3767 PF12597.3 EWC45572.1 - 1.4e-28 98.9 1.0 1.4e-28 98.9 0.7 1.8 1 1 1 2 2 2 1 Protein of unknown function (DUF3767) DUF1744 PF08490.7 EWC45573.1 - 2.4e-147 490.6 0.3 3.3e-147 490.1 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1744) DNA_pol_B_exo1 PF03104.14 EWC45573.1 - 3.8e-67 226.4 0.6 2.9e-66 223.5 0.2 2.5 3 0 0 3 3 3 1 DNA polymerase family B, exonuclease domain DNA_pol_B PF00136.16 EWC45573.1 - 4.3e-22 78.5 0.0 1.9e-21 76.4 0.0 1.9 1 1 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo2 PF10108.4 EWC45573.1 - 8.1e-09 35.3 0.1 2.1e-08 33.9 0.0 1.6 1 0 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.1 EWC45573.1 - 3.7e-06 26.8 0.1 1.4e-05 24.9 0.0 2.1 2 0 0 2 2 2 1 RNase_H superfamily zf-DNA_Pol PF08996.5 EWC45573.1 - 0.13 11.5 5.2 0.61 9.4 3.7 1.9 1 1 1 2 2 2 0 DNA Polymerase alpha zinc finger Cpn60_TCP1 PF00118.19 EWC45574.1 - 5.7e-141 470.4 7.2 6.6e-141 470.2 5.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family GAD PF02938.9 EWC45574.1 - 0.017 15.2 0.1 0.074 13.2 0.0 2.1 1 0 0 1 1 1 0 GAD domain VanZ PF04892.7 EWC45575.1 - 2.2e-06 27.6 0.0 2.7e-06 27.3 0.0 1.1 1 0 0 1 1 1 1 VanZ like family DUF1180 PF06679.7 EWC45575.1 - 0.13 12.1 0.0 0.14 12.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) F-box PF00646.28 EWC45576.1 - 0.00015 21.3 0.0 0.00043 19.8 0.0 1.8 1 0 0 1 1 1 1 F-box domain CAP_N PF01213.14 EWC45576.1 - 0.032 13.5 3.8 0.052 12.8 2.6 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal F-box-like PF12937.2 EWC45576.1 - 0.097 12.4 0.6 0.55 10.0 0.0 2.4 2 0 0 2 2 2 0 F-box-like Nucleoplasmin PF03066.10 EWC45576.1 - 3 7.3 7.0 5.9 6.3 4.8 1.4 1 0 0 1 1 1 0 Nucleoplasmin Inp1 PF12634.2 EWC45577.1 - 6e-16 58.4 0.0 1.3e-15 57.3 0.0 1.6 1 0 0 1 1 1 1 Inheritance of peroxisomes protein 1 Voldacs PF03517.8 EWC45577.1 - 0.03 14.1 0.5 0.61 9.9 0.1 2.4 2 0 0 2 2 2 0 Regulator of volume decrease after cellular swelling Ribosomal_60s PF00428.14 EWC45577.1 - 0.36 11.2 18.0 0.13 12.6 3.2 2.7 2 0 0 2 2 2 0 60s Acidic ribosomal protein Daxx PF03344.10 EWC45577.1 - 1 7.7 5.9 0.14 10.6 0.1 2.0 2 0 0 2 2 2 0 Daxx Family Pyr_redox_dim PF02852.17 EWC45578.1 - 1.1e-38 131.6 0.2 3.1e-38 130.2 0.1 1.8 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox_2 PF07992.9 EWC45578.1 - 1.4e-36 126.3 19.3 8.4e-36 123.7 13.4 3.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 EWC45578.1 - 2e-20 72.9 14.5 4.8e-19 68.5 1.1 3.7 4 1 1 5 5 3 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 EWC45578.1 - 7.2e-12 44.8 3.6 7.2e-12 44.8 2.5 2.9 2 1 1 3 3 3 1 Glucose inhibited division protein A FAD_oxidored PF12831.2 EWC45578.1 - 9.7e-12 44.6 0.2 9.7e-12 44.6 0.1 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 EWC45578.1 - 3e-09 37.2 0.9 4.7e-06 26.8 0.2 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 EWC45578.1 - 1.2e-07 30.9 3.3 1.2e-07 30.9 2.3 2.8 3 1 0 3 3 3 1 FAD binding domain Thi4 PF01946.12 EWC45578.1 - 7e-06 25.3 2.3 7e-06 25.3 1.6 2.8 1 1 1 2 2 2 1 Thi4 family K_oxygenase PF13434.1 EWC45578.1 - 1.7e-05 23.9 1.9 0.063 12.1 0.0 3.0 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.19 EWC45578.1 - 3e-05 23.0 22.4 0.0066 15.3 1.6 4.2 2 2 1 4 4 4 4 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EWC45578.1 - 5.7e-05 23.0 4.2 0.00044 20.2 0.3 2.9 3 0 0 3 3 2 2 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.9 EWC45578.1 - 0.00013 20.6 18.9 0.00037 19.0 1.3 4.2 4 0 0 4 4 4 2 HI0933-like protein FAD_binding_3 PF01494.14 EWC45578.1 - 0.0004 19.5 14.0 0.026 13.5 0.7 3.2 2 1 1 3 3 3 3 FAD binding domain AlaDh_PNT_C PF01262.16 EWC45578.1 - 0.003 17.1 6.5 0.024 14.1 0.3 2.9 3 0 0 3 3 3 1 Alanine dehydrogenase/PNT, C-terminal domain Arch_flagellin PF01917.11 EWC45578.1 - 0.015 14.9 1.0 0.024 14.2 0.7 1.3 1 0 0 1 1 1 0 Archaebacterial flagellin Lycopene_cycl PF05834.7 EWC45578.1 - 0.033 13.1 2.0 0.063 12.1 0.0 2.3 3 0 0 3 3 3 0 Lycopene cyclase protein NAD_binding_7 PF13241.1 EWC45578.1 - 0.066 13.4 4.4 1.4 9.1 0.6 3.4 3 1 0 3 3 3 0 Putative NAD(P)-binding MIF4G PF02854.14 EWC45579.1 - 1.9e-23 83.0 0.4 1.4e-21 76.8 0.1 2.3 2 0 0 2 2 2 2 MIF4G domain MA3 PF02847.12 EWC45579.1 - 6.3e-20 70.9 0.0 2.5e-19 69.0 0.0 2.1 2 0 0 2 2 2 1 MA3 domain Bromodomain PF00439.20 EWC45580.1 - 8.8e-39 131.3 6.3 5.9e-21 74.1 0.1 3.0 3 0 0 3 3 3 2 Bromodomain BAH PF01426.13 EWC45580.1 - 9.8e-18 64.0 0.5 1.9e-17 63.1 0.4 1.5 1 0 0 1 1 1 1 BAH domain CDC45 PF02724.9 EWC45580.1 - 0.00038 18.6 14.8 0.00069 17.7 10.3 1.4 1 0 0 1 1 1 1 CDC45-like protein Nop14 PF04147.7 EWC45580.1 - 0.0025 15.8 31.9 0.0049 14.8 22.1 1.4 1 0 0 1 1 1 1 Nop14-like family Daxx PF03344.10 EWC45580.1 - 0.015 13.8 30.1 0.033 12.7 20.8 1.5 1 0 0 1 1 1 0 Daxx Family PCI_Csn8 PF10075.4 EWC45581.1 - 2.5e-39 134.3 0.0 3.5e-39 133.8 0.0 1.2 1 0 0 1 1 1 1 COP9 signalosome, subunit CSN8 SAC3_GANP PF03399.11 EWC45581.1 - 2.9e-23 82.4 0.1 3.9e-23 82.0 0.0 1.1 1 0 0 1 1 1 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family Sec34 PF04136.10 EWC45582.1 - 1.9e-30 105.6 0.4 8.1e-30 103.6 0.2 2.0 2 0 0 2 2 2 1 Sec34-like family IncA PF04156.9 EWC45582.1 - 0.19 11.2 4.2 0.45 10.0 2.9 1.6 1 0 0 1 1 1 0 IncA protein Baculo_PEP_C PF04513.7 EWC45582.1 - 9.4 6.0 7.7 2.8 7.7 0.2 3.6 5 0 0 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus RCC1 PF00415.13 EWC45583.1 - 2.7e-25 88.3 1.4 7.6e-06 26.0 0.0 7.2 7 0 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 EWC45583.1 - 4.6e-12 45.2 11.5 7e-08 31.8 0.0 5.1 6 0 0 6 6 6 2 Regulator of chromosome condensation (RCC1) repeat Suf PF05843.9 EWC45584.1 - 4.9e-78 262.6 0.0 4.9e-78 262.6 0.0 4.9 5 2 0 5 5 5 2 Suppressor of forked protein (Suf) TPR_16 PF13432.1 EWC45584.1 - 1.4e-07 31.9 2.7 0.00028 21.4 0.0 4.2 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.1 EWC45584.1 - 1.6e-06 28.3 0.5 0.3 11.4 0.0 4.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.1 EWC45584.1 - 2.9e-05 24.2 9.1 0.012 16.1 0.1 6.1 5 2 3 8 8 8 1 Tetratricopeptide repeat HAT PF02184.11 EWC45584.1 - 0.042 13.5 0.0 0.042 13.5 0.0 2.6 4 0 0 4 4 4 0 HAT (Half-A-TPR) repeat Piwi PF02171.12 EWC45585.1 - 1.1e-86 290.5 0.2 1.7e-86 289.9 0.2 1.2 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.17 EWC45585.1 - 7.2e-20 70.6 1.0 1.6e-19 69.5 0.7 1.6 1 0 0 1 1 1 1 PAZ domain DUF1785 PF08699.5 EWC45585.1 - 1.4e-17 62.8 0.0 2.7e-17 61.8 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1785) FAM177 PF14774.1 EWC45585.1 - 0.14 12.0 0.0 0.3 11.0 0.0 1.4 1 0 0 1 1 1 0 FAM177 family Ank_2 PF12796.2 EWC45586.1 - 3.2e-140 456.8 28.1 1.1e-20 73.7 1.0 11.7 4 2 6 12 12 12 12 Ankyrin repeats (3 copies) Ank PF00023.25 EWC45586.1 - 2.7e-100 323.5 44.7 5.6e-06 25.9 0.1 25.5 26 0 0 26 26 26 19 Ankyrin repeat Ank_3 PF13606.1 EWC45586.1 - 8.5e-84 267.0 25.8 0.00039 20.3 0.0 26.4 27 1 1 28 28 27 17 Ankyrin repeat Ank_4 PF13637.1 EWC45586.1 - 2.4e-82 270.0 27.5 2.5e-09 37.4 0.1 19.6 7 5 12 20 20 20 17 Ankyrin repeats (many copies) Ank_5 PF13857.1 EWC45586.1 - 1.7e-59 196.4 40.4 7.9e-05 22.7 0.0 21.7 9 6 15 24 24 24 17 Ankyrin repeats (many copies) NACHT PF05729.7 EWC45586.1 - 8.3e-06 25.5 0.0 2e-05 24.2 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.1 EWC45586.1 - 0.0079 16.3 0.0 0.026 14.6 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 EWC45586.1 - 0.019 14.9 0.0 0.077 12.9 0.0 2.1 1 0 0 1 1 1 0 AAA ATPase domain ArgK PF03308.11 EWC45586.1 - 0.03 13.1 0.2 1.2 7.8 0.3 2.5 2 0 0 2 2 2 0 ArgK protein UDPG_MGDP_dh_C PF03720.10 EWC45586.1 - 0.036 14.1 0.1 27 4.9 0.0 5.0 4 0 0 4 4 4 0 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain Glyco_hydro_56 PF01630.13 EWC45586.1 - 0.066 11.8 0.0 0.1 11.2 0.0 1.2 1 0 0 1 1 1 0 Hyaluronidase FLgD_tudor PF13861.1 EWC45586.1 - 0.085 12.8 0.0 0.44 10.5 0.0 2.2 2 1 0 2 2 2 0 FlgD Tudor-like domain Shigella_OspC PF06128.6 EWC45586.1 - 0.29 10.6 0.2 29 4.0 0.0 4.1 4 0 0 4 4 4 0 Shigella flexneri OspC protein DUF2207 PF09972.4 EWC45586.1 - 0.65 8.5 0.0 1 7.8 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) zf-H2C2 PF09337.5 EWC45587.1 - 4e-18 64.5 4.1 7.6e-18 63.6 2.9 1.5 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger Acetyltransf_1 PF00583.19 EWC45587.1 - 0.057 13.4 0.0 0.13 12.3 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Acetyltransf_3 PF13302.1 EWC45587.1 - 0.13 12.4 0.1 0.38 10.9 0.0 1.9 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain RAM PF15320.1 EWC45587.1 - 1.6 9.0 7.5 0.36 11.1 1.3 2.3 2 0 0 2 2 2 0 mRNA cap methylation, RNMT-activating mini protein Bac_rhodopsin PF01036.13 EWC45588.1 - 3.5e-41 140.9 21.2 4.3e-41 140.6 14.7 1.0 1 0 0 1 1 1 1 Bacteriorhodopsin-like protein ASF1_hist_chap PF04729.8 EWC45589.1 - 5.8e-66 220.8 0.0 7.9e-66 220.4 0.0 1.2 1 0 0 1 1 1 1 ASF1 like histone chaperone HAD_2 PF13419.1 EWC45590.1 - 4.9e-18 65.9 0.0 6.5e-18 65.5 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 EWC45590.1 - 0.00028 20.5 0.0 0.00054 19.6 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Nop PF01798.13 EWC45591.1 - 1.2e-60 203.2 0.0 3.3e-60 201.7 0.0 1.8 1 0 0 1 1 1 1 Putative snoRNA binding domain NOSIC PF08060.8 EWC45591.1 - 2e-25 88.3 0.4 4.3e-25 87.2 0.3 1.6 1 0 0 1 1 1 1 NOSIC (NUC001) domain NOP5NT PF08156.8 EWC45591.1 - 1.2e-21 76.6 0.0 1.2e-21 76.6 0.0 3.2 2 1 0 2 2 2 1 NOP5NT (NUC127) domain DUF4604 PF15377.1 EWC45591.1 - 0.14 12.3 54.4 0.23 11.6 37.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) Cpn60_TCP1 PF00118.19 EWC45592.1 - 1.6e-145 485.4 1.4 1.8e-145 485.2 1.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family FRQ PF09421.5 EWC45593.1 - 1.3e-64 218.5 19.4 4e-43 147.4 5.0 3.5 1 1 1 2 2 2 2 Frequency clock protein F-box PF00646.28 EWC45594.1 - 0.0093 15.5 0.1 0.027 14.1 0.1 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 EWC45594.1 - 0.013 15.2 0.1 0.028 14.1 0.1 1.5 1 0 0 1 1 1 0 F-box-like DER1 PF04511.10 EWC45595.1 - 5.7e-54 182.6 5.9 6.5e-54 182.4 4.1 1.0 1 0 0 1 1 1 1 Der1-like family FA_hydroxylase PF04116.8 EWC45596.1 - 4.1e-11 43.2 20.0 4.1e-11 43.2 13.8 2.4 2 1 1 3 3 3 1 Fatty acid hydroxylase superfamily DUF599 PF04654.7 EWC45596.1 - 0.06 12.4 1.8 0.2 10.8 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function, DUF599 DUF3816 PF12822.2 EWC45596.1 - 1.6 8.6 6.3 0.44 10.4 2.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3816) ABC_tran PF00005.22 EWC45597.1 - 5.8e-18 65.5 0.0 2e-17 63.7 0.0 1.8 1 1 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 EWC45597.1 - 1.2e-06 28.6 0.1 0.029 14.3 0.1 2.1 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.1 EWC45597.1 - 0.00014 21.2 0.1 0.00027 20.3 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_25 PF13481.1 EWC45597.1 - 0.00074 18.9 0.9 0.013 14.9 0.6 2.2 1 1 0 1 1 1 1 AAA domain SMC_N PF02463.14 EWC45597.1 - 0.0026 17.0 0.0 1.3 8.2 0.0 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_10 PF12846.2 EWC45597.1 - 0.0034 16.8 0.0 0.0043 16.5 0.0 1.2 1 0 0 1 1 1 1 AAA-like domain AAA_16 PF13191.1 EWC45597.1 - 0.019 14.9 0.5 0.029 14.3 0.4 1.5 1 1 0 1 1 1 0 AAA ATPase domain DUF258 PF03193.11 EWC45597.1 - 0.023 13.8 0.0 0.03 13.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF258 FtsK_SpoIIIE PF01580.13 EWC45597.1 - 0.027 13.9 0.1 0.07 12.5 0.0 1.6 2 0 0 2 2 2 0 FtsK/SpoIIIE family ArgK PF03308.11 EWC45597.1 - 0.056 12.2 0.1 0.075 11.7 0.1 1.1 1 0 0 1 1 1 0 ArgK protein AAA_15 PF13175.1 EWC45597.1 - 0.06 12.3 0.0 7.8 5.4 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain AAA_23 PF13476.1 EWC45597.1 - 0.067 13.5 0.0 0.099 12.9 0.0 1.2 1 0 0 1 1 1 0 AAA domain DUF3584 PF12128.3 EWC45597.1 - 0.11 9.7 0.1 0.16 9.3 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) 6PF2K PF01591.13 EWC45598.1 - 6.2e-64 215.1 0.0 8.6e-64 214.6 0.0 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase WD40 PF00400.27 EWC45598.1 - 3.3e-41 137.7 16.8 3.5e-07 29.8 0.0 11.2 11 0 0 11 11 11 8 WD domain, G-beta repeat His_Phos_1 PF00300.17 EWC45598.1 - 1.2e-21 77.4 0.5 2.1e-21 76.6 0.4 1.4 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.1 EWC45598.1 - 0.0049 16.7 0.0 0.019 14.8 0.0 2.0 1 0 0 1 1 1 1 AAA domain WD40 PF00400.27 EWC45599.1 - 1.7e-70 230.5 9.8 9.8e-13 47.4 0.0 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat Tup_N PF08581.5 EWC45599.1 - 3.5e-20 71.9 5.6 5.6e-20 71.3 3.9 1.3 1 0 0 1 1 1 1 Tup N-terminal eIF2A PF08662.6 EWC45599.1 - 4.4e-06 26.5 0.0 0.0078 15.9 0.0 3.1 2 1 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.11 EWC45599.1 - 0.001 17.4 0.2 0.0037 15.6 0.1 1.9 1 1 1 2 2 2 2 Cytochrome D1 heme domain Nup160 PF11715.3 EWC45599.1 - 0.001 17.2 0.1 2.1 6.3 0.0 3.8 2 1 3 5 5 5 2 Nucleoporin Nup120/160 PD40 PF07676.7 EWC45599.1 - 0.0086 15.7 0.3 44 3.8 0.0 4.8 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat Nucleoporin_N PF08801.6 EWC45599.1 - 0.023 13.4 0.2 0.79 8.4 0.1 2.9 2 1 0 2 2 2 0 Nup133 N terminal like Nbas_N PF15492.1 EWC45599.1 - 0.041 12.9 0.0 8.3 5.4 0.0 2.7 3 0 0 3 3 3 0 Neuroblastoma-amplified sequence, N terminal PAT1 PF09770.4 EWC45599.1 - 1.6 6.9 37.6 2.1 6.5 26.1 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 zf-C2H2 PF00096.21 EWC45600.1 - 1.5e-14 53.3 22.9 0.0006 20.0 0.3 5.0 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 EWC45600.1 - 1.4e-11 44.0 14.1 7.6e-08 32.2 1.3 5.6 6 0 0 6 6 6 3 Zinc-finger double domain zf-C2H2_4 PF13894.1 EWC45600.1 - 0.037 14.3 0.3 0.037 14.3 0.2 5.5 6 0 0 6 6 6 0 C2H2-type zinc finger GED PF02212.13 EWC45600.1 - 3.9 7.4 11.3 18 5.3 0.8 4.0 1 1 2 3 3 3 0 Dynamin GTPase effector domain zf-C2H2 PF00096.21 EWC45601.1 - 0.022 15.1 5.2 0.8 10.1 0.6 3.0 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EWC45601.1 - 1.1 9.7 16.4 1.4 9.3 1.1 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger Herpes_capsid PF06112.6 EWC45601.1 - 8.6 6.3 31.1 41 4.1 5.3 3.1 2 1 0 2 2 2 0 Gammaherpesvirus capsid protein Ribosomal_L2_C PF03947.13 EWC45602.1 - 9.6e-40 135.3 2.6 1.4e-39 134.8 1.8 1.2 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.18 EWC45602.1 - 2.5e-13 49.7 0.1 5.2e-13 48.7 0.1 1.6 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain SNF2_N PF00176.18 EWC45603.1 - 5.7e-81 271.5 0.1 5.7e-81 271.5 0.0 2.8 3 0 0 3 3 3 1 SNF2 family N-terminal domain Bromodomain PF00439.20 EWC45603.1 - 4.4e-20 71.3 0.3 1.3e-19 69.8 0.2 1.8 1 0 0 1 1 1 1 Bromodomain SnAC PF14619.1 EWC45603.1 - 7.1e-17 61.3 2.2 7.1e-17 61.3 1.5 5.5 6 2 1 7 7 7 1 Snf2-ATP coupling, chromatin remodelling complex Helicase_C PF00271.26 EWC45603.1 - 2.6e-16 59.2 0.0 2.6e-16 59.2 0.0 2.9 3 0 0 3 3 3 1 Helicase conserved C-terminal domain HSA PF07529.8 EWC45603.1 - 1.3e-11 44.0 9.2 1.3e-11 44.0 6.4 3.9 3 1 0 3 3 3 1 HSA Mem_trans PF03547.13 EWC45603.1 - 0.44 8.8 1.5 0.86 7.8 1.1 1.4 1 0 0 1 1 1 0 Membrane transport protein TGS PF02824.16 EWC45604.1 - 4.3e-21 74.5 0.0 9.3e-21 73.4 0.0 1.6 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.18 EWC45604.1 - 2.4e-20 72.6 0.3 1.7e-19 69.8 0.2 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 EWC45604.1 - 8.6e-14 51.0 0.0 1.4e-13 50.4 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.18 EWC45604.1 - 0.00022 21.0 0.3 0.025 14.4 0.0 2.3 1 1 1 2 2 2 1 Dynamin family Miro PF08477.8 EWC45604.1 - 0.017 15.5 0.0 0.035 14.6 0.0 1.5 1 0 0 1 1 1 0 Miro-like protein ArgK PF03308.11 EWC45604.1 - 0.048 12.4 0.1 0.15 10.7 0.0 1.8 2 0 0 2 2 2 0 ArgK protein GTP_EFTU PF00009.22 EWC45604.1 - 0.071 12.5 1.8 10 5.5 0.0 3.2 2 1 1 3 3 3 0 Elongation factor Tu GTP binding domain cobW PF02492.14 EWC45604.1 - 0.075 12.4 0.2 1.7 8.0 0.0 2.7 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain MCM PF00493.18 EWC45604.1 - 0.099 11.4 0.0 0.15 10.8 0.0 1.3 1 0 0 1 1 1 0 MCM2/3/5 family AIG1 PF04548.11 EWC45604.1 - 0.11 11.6 0.0 0.16 11.0 0.0 1.2 1 0 0 1 1 1 0 AIG1 family MMR_HSR1 PF01926.18 EWC45605.1 - 1.9e-07 31.0 0.1 4.1e-07 29.9 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.11 EWC45605.1 - 0.00037 19.6 0.4 0.00072 18.7 0.0 1.6 2 0 0 2 2 2 1 AIG1 family DUF258 PF03193.11 EWC45605.1 - 0.00054 19.1 0.0 0.0013 17.9 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function, DUF258 FeoB_N PF02421.13 EWC45605.1 - 0.00077 18.7 2.0 0.0014 17.9 0.1 2.2 2 1 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.18 EWC45605.1 - 0.0017 18.2 5.2 0.08 12.7 0.1 3.2 2 1 1 3 3 3 1 Dynamin family GrpE PF01025.14 EWC45605.1 - 0.002 17.7 1.5 0.0036 16.8 1.0 1.4 1 0 0 1 1 1 1 GrpE Septin PF00735.13 EWC45605.1 - 0.0029 16.6 1.9 0.017 14.1 1.1 2.3 1 1 0 1 1 1 1 Septin DLIC PF05783.6 EWC45605.1 - 0.0035 16.0 0.0 0.0079 14.9 0.0 1.6 1 0 0 1 1 1 1 Dynein light intermediate chain (DLIC) Miro PF08477.8 EWC45605.1 - 0.0044 17.5 0.5 0.012 16.1 0.0 2.0 2 0 0 2 2 2 1 Miro-like protein SAM_MT PF04445.8 EWC45605.1 - 0.015 14.4 0.5 0.06 12.4 0.0 2.0 2 0 0 2 2 2 0 Putative SAM-dependent methyltransferase NB-ARC PF00931.17 EWC45605.1 - 0.018 13.9 0.6 0.07 11.9 0.0 2.2 2 0 0 2 2 2 0 NB-ARC domain AAA_33 PF13671.1 EWC45605.1 - 0.025 14.4 0.2 0.77 9.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain SRPRB PF09439.5 EWC45605.1 - 0.031 13.4 0.1 0.067 12.4 0.1 1.6 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_17 PF13207.1 EWC45605.1 - 0.12 13.2 1.5 0.23 12.2 0.3 2.1 2 1 0 2 2 2 0 AAA domain COG2 PF06148.6 EWC45605.1 - 0.33 10.8 2.3 2.9 7.7 1.0 2.6 3 0 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 ATP_bind_1 PF03029.12 EWC45605.1 - 0.36 10.3 5.9 0.32 10.4 0.6 2.6 1 1 2 3 3 3 0 Conserved hypothetical ATP binding protein DUF1003 PF06210.6 EWC45605.1 - 0.51 10.2 5.0 1.2 9.0 3.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1003) ABC_tran PF00005.22 EWC45605.1 - 0.63 10.3 4.2 0.32 11.2 0.4 2.3 2 1 0 2 2 2 0 ABC transporter AAA_23 PF13476.1 EWC45605.1 - 4.9 7.4 7.9 2.3 8.4 0.1 2.4 2 1 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.18 EWC45606.1 - 5.8e-08 32.7 1.5 6.9e-08 32.4 0.2 1.7 2 1 0 2 2 2 1 50S ribosome-binding GTPase AIG1 PF04548.11 EWC45606.1 - 3.4e-05 23.0 0.1 3.4e-05 23.0 0.1 1.9 2 0 0 2 2 2 1 AIG1 family DUF258 PF03193.11 EWC45606.1 - 0.00028 20.0 0.1 0.00058 19.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Miro PF08477.8 EWC45606.1 - 0.00037 20.9 2.3 0.00043 20.7 0.1 2.1 2 0 0 2 2 2 1 Miro-like protein SAM_MT PF04445.8 EWC45606.1 - 0.0014 17.8 0.0 0.003 16.7 0.0 1.5 1 0 0 1 1 1 1 Putative SAM-dependent methyltransferase Arf PF00025.16 EWC45606.1 - 0.0099 15.1 1.0 0.19 10.9 0.1 2.7 2 1 1 3 3 3 1 ADP-ribosylation factor family NB-ARC PF00931.17 EWC45606.1 - 0.011 14.5 2.2 0.02 13.7 0.1 2.1 2 0 0 2 2 2 0 NB-ARC domain AAA_18 PF13238.1 EWC45606.1 - 0.047 14.0 3.3 1.8 8.8 0.1 2.4 2 1 0 2 2 2 0 AAA domain AAA_22 PF13401.1 EWC45606.1 - 0.049 13.7 0.1 0.16 12.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain IIGP PF05049.8 EWC45606.1 - 0.065 12.0 5.6 0.18 10.5 0.3 2.2 2 0 0 2 2 2 0 Interferon-inducible GTPase (IIGP) ABC_tran PF00005.22 EWC45606.1 - 0.072 13.3 0.9 0.22 11.8 0.0 2.1 2 0 0 2 2 2 0 ABC transporter FeoB_N PF02421.13 EWC45606.1 - 0.088 12.0 1.0 0.13 11.5 0.0 1.8 2 0 0 2 2 2 0 Ferrous iron transport protein B Dynamin_N PF00350.18 EWC45606.1 - 0.17 11.7 6.7 8.9 6.0 0.1 3.3 2 1 1 3 3 3 0 Dynamin family Nsp1_C PF05064.8 EWC45606.1 - 1 9.0 5.5 18 5.0 1.4 2.8 1 1 2 3 3 3 0 Nsp1-like C-terminal region NTPase_1 PF03266.10 EWC45606.1 - 1.4 8.6 6.0 5.3 6.7 0.3 2.3 2 0 0 2 2 2 0 NTPase ATP_bind_1 PF03029.12 EWC45606.1 - 8.4 5.8 7.0 2.6 7.5 1.4 2.1 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein ABC_tran PF00005.22 EWC45608.1 - 9.6e-55 184.6 0.0 4.9e-31 107.8 0.0 2.8 2 1 0 2 2 2 2 ABC transporter ABC_membrane PF00664.18 EWC45608.1 - 4.9e-54 183.5 9.2 2.7e-33 115.5 0.1 3.5 3 0 0 3 3 3 3 ABC transporter transmembrane region AAA_21 PF13304.1 EWC45608.1 - 6.1e-10 39.5 0.1 0.038 13.9 0.2 4.2 3 1 0 3 3 3 2 AAA domain AAA_23 PF13476.1 EWC45608.1 - 1.5e-07 31.9 4.8 3.5e-05 24.2 0.0 3.1 3 0 0 3 3 3 2 AAA domain AAA_25 PF13481.1 EWC45608.1 - 3e-07 30.0 0.0 0.0049 16.2 0.0 2.7 2 0 0 2 2 2 2 AAA domain SMC_N PF02463.14 EWC45608.1 - 3.1e-07 29.8 2.9 0.079 12.1 0.1 4.0 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain Zeta_toxin PF06414.7 EWC45608.1 - 3.1e-05 23.1 0.4 0.15 11.1 0.0 2.4 2 0 0 2 2 2 2 Zeta toxin MMR_HSR1 PF01926.18 EWC45608.1 - 0.0001 22.2 0.3 0.12 12.3 0.1 2.8 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_29 PF13555.1 EWC45608.1 - 0.00013 21.4 0.1 0.58 9.7 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.1 EWC45608.1 - 0.00015 21.8 2.0 0.076 12.9 0.1 3.0 2 0 0 2 2 2 1 AAA ATPase domain AAA_17 PF13207.1 EWC45608.1 - 0.00024 21.9 0.2 1.8 9.4 0.0 3.3 2 0 0 2 2 2 2 AAA domain AAA_10 PF12846.2 EWC45608.1 - 0.00025 20.5 1.6 0.072 12.5 0.0 2.7 2 1 0 3 3 3 1 AAA-like domain Miro PF08477.8 EWC45608.1 - 0.00032 21.1 0.2 0.73 10.3 0.0 2.8 2 0 0 2 2 2 2 Miro-like protein AAA_22 PF13401.1 EWC45608.1 - 0.00033 20.8 0.1 2.7 8.1 0.0 3.5 3 0 0 3 3 3 1 AAA domain DUF258 PF03193.11 EWC45608.1 - 0.00036 19.7 0.1 0.28 10.3 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 DUF87 PF01935.12 EWC45608.1 - 0.00047 20.0 1.0 0.078 12.7 0.0 3.1 3 0 0 3 3 2 1 Domain of unknown function DUF87 AAA_18 PF13238.1 EWC45608.1 - 0.00061 20.1 1.5 0.36 11.1 0.0 3.2 3 0 0 3 3 2 1 AAA domain T2SE PF00437.15 EWC45608.1 - 0.0011 17.9 0.0 0.033 13.0 0.0 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein IstB_IS21 PF01695.12 EWC45608.1 - 0.0012 18.2 0.0 1.2 8.4 0.0 2.4 2 0 0 2 2 2 2 IstB-like ATP binding protein MobB PF03205.9 EWC45608.1 - 0.0025 17.5 1.8 2 8.1 0.0 3.6 4 0 0 4 4 4 1 Molybdopterin guanine dinucleotide synthesis protein B FtsK_SpoIIIE PF01580.13 EWC45608.1 - 0.0027 17.2 0.1 1.4 8.3 0.0 2.4 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA PF00004.24 EWC45608.1 - 0.0048 17.0 0.1 4.7 7.4 0.0 3.4 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) TrwB_AAD_bind PF10412.4 EWC45608.1 - 0.0071 15.0 0.2 0.63 8.6 0.0 2.3 2 0 0 2 2 2 1 Type IV secretion-system coupling protein DNA-binding domain RNA_helicase PF00910.17 EWC45608.1 - 0.029 14.5 0.2 8.4 6.6 0.0 2.9 3 0 0 3 3 2 0 RNA helicase Arch_ATPase PF01637.13 EWC45608.1 - 0.036 13.7 2.5 0.055 13.1 0.0 2.5 3 0 0 3 3 2 0 Archaeal ATPase WBP-1 PF11669.3 EWC45608.1 - 0.04 13.9 1.0 0.14 12.2 0.7 1.9 1 0 0 1 1 1 0 WW domain-binding protein 1 AAA_33 PF13671.1 EWC45608.1 - 0.052 13.4 0.0 8.3 6.2 0.0 2.8 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.1 EWC45608.1 - 0.059 13.1 0.7 2.1 8.1 0.0 3.1 3 0 0 3 3 3 0 Part of AAA domain AAA_24 PF13479.1 EWC45608.1 - 0.07 12.6 1.8 12 5.4 0.0 3.2 3 0 0 3 3 3 0 AAA domain UPF0079 PF02367.12 EWC45608.1 - 0.089 12.4 0.2 3 7.5 0.0 2.5 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 Adeno_IVa2 PF02456.10 EWC45608.1 - 0.16 10.6 0.0 0.74 8.3 0.0 1.9 2 0 0 2 2 2 0 Adenovirus IVa2 protein NACHT PF05729.7 EWC45608.1 - 0.2 11.2 1.7 3.6 7.2 0.1 2.5 2 0 0 2 2 2 0 NACHT domain Dynamin_N PF00350.18 EWC45608.1 - 3.7 7.3 5.9 12 5.7 0.1 2.9 3 0 0 3 3 2 0 Dynamin family SPATA25 PF15218.1 EWC45609.1 - 0.043 13.2 1.0 0.051 12.9 0.7 1.1 1 0 0 1 1 1 0 Spermatogenesis-associated protein 25 Asp PF00026.18 EWC45610.1 - 1.9e-30 106.1 0.0 2.6e-30 105.7 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Syndecan PF01034.15 EWC45610.1 - 0.02 14.5 0.1 0.04 13.5 0.1 1.4 1 0 0 1 1 1 0 Syndecan domain ORC2 PF04084.9 EWC45611.1 - 2.2e-87 292.9 0.0 2.7e-87 292.6 0.0 1.1 1 0 0 1 1 1 1 Origin recognition complex subunit 2 ORC6 PF05460.8 EWC45611.1 - 4.6 6.2 10.1 8.1 5.4 5.5 2.0 1 1 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) ArgJ PF01960.13 EWC45612.1 - 1.3e-141 471.4 1.0 1.5e-141 471.3 0.7 1.0 1 0 0 1 1 1 1 ArgJ family ATP-grasp PF02222.17 EWC45612.1 - 0.035 13.4 0.0 0.059 12.7 0.0 1.3 1 0 0 1 1 1 0 ATP-grasp domain Pep3_Vps18 PF05131.9 EWC45613.1 - 1.8e-39 134.5 0.5 2.4e-38 130.8 0.0 2.6 3 0 0 3 3 3 1 Pep3/Vps18/deep orange family Clathrin PF00637.15 EWC45613.1 - 1.6e-08 34.2 12.9 1e-06 28.4 0.4 3.4 3 1 0 3 3 3 2 Region in Clathrin and VPS zf-RING_2 PF13639.1 EWC45613.1 - 3.6e-05 23.4 0.2 7.2e-05 22.5 0.1 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.1 EWC45613.1 - 0.0043 16.7 0.7 0.0086 15.7 0.5 1.5 1 0 0 1 1 1 1 zinc-RING finger domain Vps39_2 PF10367.4 EWC45613.1 - 0.021 14.9 0.5 0.054 13.6 0.0 2.0 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 2 zf-rbx1 PF12678.2 EWC45613.1 - 0.071 13.2 0.2 0.17 12.0 0.1 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 EWC45613.1 - 0.098 12.7 0.6 0.23 11.5 0.4 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EWC45613.1 - 0.1 12.2 0.1 0.1 12.2 0.1 1.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DUF1664 PF07889.7 EWC45613.1 - 0.12 12.1 1.5 0.89 9.3 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) PPR_3 PF13812.1 EWC45613.1 - 0.27 11.5 1.4 7 7.2 0.0 3.6 4 0 0 4 4 4 0 Pentatricopeptide repeat domain Pkinase PF00069.20 EWC45614.1 - 7.1e-68 228.5 0.0 1.2e-67 227.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC45614.1 - 1.1e-49 168.8 0.0 2.2e-49 167.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Ras_bdg_2 PF14847.1 EWC45614.1 - 3.8e-24 84.6 0.0 2.5e-23 81.9 0.0 2.2 2 0 0 2 2 2 1 Ras-binding domain of Byr2 SAM_2 PF07647.12 EWC45614.1 - 2.6e-17 62.4 0.0 5.9e-17 61.2 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.25 EWC45614.1 - 3e-16 59.3 0.0 6.5e-16 58.2 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Kinase-like PF14531.1 EWC45614.1 - 3e-07 29.7 0.0 2.3e-05 23.5 0.0 2.3 2 0 0 2 2 2 1 Kinase-like RA PF00788.18 EWC45614.1 - 3.5e-05 24.2 0.0 6.5e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain CDC45 PF02724.9 EWC45614.1 - 0.28 9.1 9.5 0.61 8.0 6.6 1.5 1 0 0 1 1 1 0 CDC45-like protein RRN3 PF05327.6 EWC45614.1 - 2.8 5.9 4.5 6.7 4.6 3.1 1.6 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Nop14 PF04147.7 EWC45614.1 - 5 4.9 28.0 0.013 13.4 12.4 1.7 2 0 0 2 2 2 0 Nop14-like family SAC3_GANP PF03399.11 EWC45615.1 - 1.4e-37 129.2 0.7 2e-37 128.7 0.5 1.2 1 0 0 1 1 1 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family CLTH PF10607.4 EWC45616.1 - 5.1e-32 110.5 0.2 1e-31 109.5 0.0 1.6 2 0 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.6 EWC45616.1 - 0.0014 18.3 0.0 0.0038 16.9 0.0 1.8 1 0 0 1 1 1 1 LisH GCOM2 PF15328.1 EWC45616.1 - 0.046 13.4 1.2 0.092 12.4 0.9 1.5 1 0 0 1 1 1 0 Putative GRINL1B complex locus protein 2 SecY PF00344.15 EWC45618.1 - 6.1e-97 324.6 10.8 7.7e-97 324.3 7.5 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.4 EWC45618.1 - 2.3e-18 65.4 0.3 7.8e-18 63.6 0.2 2.0 1 0 0 1 1 1 1 Plug domain of Sec61p Myb_DNA-binding PF00249.26 EWC45620.1 - 0.00013 21.9 0.0 0.00023 21.1 0.0 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain BRE1 PF08647.6 EWC45621.1 - 1.8e-09 37.4 13.7 1.8e-09 37.4 9.5 6.3 3 1 2 5 5 5 1 BRE1 E3 ubiquitin ligase zf-C3HC4_2 PF13923.1 EWC45621.1 - 2.8e-07 30.4 10.0 5.4e-07 29.5 6.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 EWC45621.1 - 5.7e-07 29.0 8.2 9.8e-07 28.3 5.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EWC45621.1 - 4.2e-06 26.3 9.0 7.9e-06 25.4 6.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EWC45621.1 - 2.5e-05 23.9 9.2 4.8e-05 22.9 6.4 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.1 EWC45621.1 - 2.9e-05 23.8 7.2 5.7e-05 22.8 5.0 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.1 EWC45621.1 - 7.1e-05 22.4 5.1 0.00028 20.5 3.6 2.1 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.1 EWC45621.1 - 0.00073 19.0 3.8 0.0017 17.8 2.6 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C2HC_2 PF13913.1 EWC45621.1 - 0.0028 17.2 0.1 0.0067 16.0 0.0 1.7 1 0 0 1 1 1 1 zinc-finger of a C2HC-type zf-rbx1 PF12678.2 EWC45621.1 - 0.0055 16.7 2.0 0.015 15.3 1.4 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger DapH_N PF08503.5 EWC45621.1 - 0.016 15.2 5.6 0.65 10.1 0.7 3.9 4 0 0 4 4 3 0 Tetrahydrodipicolinate succinyltransferase N-terminal zf-RING_6 PF14835.1 EWC45621.1 - 0.041 13.6 4.2 0.089 12.5 2.9 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_4 PF14570.1 EWC45621.1 - 0.21 11.2 7.2 0.44 10.1 5.0 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.1 EWC45621.1 - 0.62 9.9 7.1 1.5 8.8 4.9 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Cupin_5 PF06172.6 EWC45622.1 - 1.5e-21 76.7 0.0 2.2e-20 73.0 0.0 2.0 1 1 0 1 1 1 1 Cupin superfamily (DUF985) DUF2431 PF10354.4 EWC45623.1 - 7e-42 143.2 0.0 9e-42 142.8 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF2431) Methyltransf_26 PF13659.1 EWC45623.1 - 0.0019 18.2 0.1 0.0031 17.5 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain TALPID3 PF15324.1 EWC45623.1 - 0.26 8.5 6.3 0.34 8.1 4.4 1.0 1 0 0 1 1 1 0 Hedgehog signalling target ABC_membrane PF00664.18 EWC45624.1 - 2e-83 279.9 35.8 2.8e-42 145.0 9.5 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 EWC45624.1 - 7.6e-70 233.5 0.2 2.6e-34 118.4 0.0 2.8 3 0 0 3 3 2 2 ABC transporter SMC_N PF02463.14 EWC45624.1 - 2.4e-15 56.3 2.3 2.6e-05 23.5 0.0 4.2 3 1 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 EWC45624.1 - 5.5e-11 42.9 0.1 0.48 10.3 0.0 4.4 3 1 0 4 4 4 4 AAA domain AAA_29 PF13555.1 EWC45624.1 - 2.7e-08 33.1 1.8 0.0005 19.5 0.2 2.9 2 0 0 2 2 2 2 P-loop containing region of AAA domain ABC_ATPase PF09818.4 EWC45624.1 - 1e-07 30.9 1.4 0.0045 15.6 0.0 3.1 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA_16 PF13191.1 EWC45624.1 - 6.6e-07 29.4 6.1 0.0007 19.6 0.0 3.4 2 1 0 2 2 2 2 AAA ATPase domain AAA_17 PF13207.1 EWC45624.1 - 9.2e-07 29.7 0.1 0.091 13.5 0.0 3.2 3 0 0 3 3 2 2 AAA domain DUF258 PF03193.11 EWC45624.1 - 1.6e-06 27.3 0.1 0.078 12.1 0.0 3.1 3 0 0 3 3 3 2 Protein of unknown function, DUF258 AAA_25 PF13481.1 EWC45624.1 - 2.2e-05 23.9 1.3 0.23 10.8 0.0 3.8 4 0 0 4 4 4 2 AAA domain AAA PF00004.24 EWC45624.1 - 4.9e-05 23.5 2.6 0.063 13.4 0.0 4.3 2 2 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.7 EWC45624.1 - 0.0001 21.4 0.4 1.5 7.8 0.0 3.3 3 0 0 3 3 3 2 Zeta toxin SbcCD_C PF13558.1 EWC45624.1 - 0.00029 20.6 2.2 0.56 10.1 0.1 3.3 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_5 PF07728.9 EWC45624.1 - 0.00082 19.1 0.5 2.1 8.0 0.0 3.9 4 0 0 4 4 4 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.1 EWC45624.1 - 0.00084 19.2 0.1 0.88 9.4 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 EWC45624.1 - 0.0027 17.4 1.7 2.6 7.8 0.3 3.4 2 0 0 2 2 2 1 Part of AAA domain AAA_23 PF13476.1 EWC45624.1 - 0.0031 17.8 0.1 3.8 7.7 0.0 3.1 3 0 0 3 3 3 1 AAA domain AAA_18 PF13238.1 EWC45624.1 - 0.0032 17.7 0.0 4.5 7.5 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_10 PF12846.2 EWC45624.1 - 0.0032 16.9 3.0 6.1 6.1 0.0 4.0 4 0 0 4 4 4 0 AAA-like domain AAA_14 PF13173.1 EWC45624.1 - 0.004 17.0 0.0 2.8 7.8 0.0 4.0 4 0 0 4 4 4 1 AAA domain DUF87 PF01935.12 EWC45624.1 - 0.0048 16.7 1.6 0.41 10.4 0.0 3.0 3 0 0 3 3 3 1 Domain of unknown function DUF87 AAA_22 PF13401.1 EWC45624.1 - 0.0054 16.8 5.5 1.3 9.1 0.3 4.2 2 2 0 2 2 2 1 AAA domain AAA_30 PF13604.1 EWC45624.1 - 0.0061 16.1 7.5 1.6 8.3 0.0 4.3 5 0 0 5 5 4 2 AAA domain GARS_C PF02843.11 EWC45624.1 - 0.0081 16.3 0.2 0.14 12.3 0.2 2.7 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, C domain G-alpha PF00503.15 EWC45624.1 - 0.017 13.8 0.0 4.7 5.7 0.0 2.5 2 1 0 2 2 2 0 G-protein alpha subunit AAA_28 PF13521.1 EWC45624.1 - 0.028 14.3 0.4 5.9 6.8 0.1 2.9 2 0 0 2 2 2 0 AAA domain MobB PF03205.9 EWC45624.1 - 0.032 13.9 0.1 5.2 6.7 0.0 2.8 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Rad17 PF03215.10 EWC45624.1 - 0.048 12.3 0.0 0.099 11.3 0.0 1.4 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein RNA_helicase PF00910.17 EWC45624.1 - 0.1 12.7 0.3 5.7 7.1 0.0 3.0 2 0 0 2 2 2 0 RNA helicase MMR_HSR1 PF01926.18 EWC45624.1 - 0.1 12.5 0.0 14 5.6 0.0 3.0 2 0 0 2 2 2 0 50S ribosome-binding GTPase APS_kinase PF01583.15 EWC45624.1 - 0.14 11.7 2.2 1.5 8.4 0.0 3.0 3 0 0 3 3 3 0 Adenylylsulphate kinase NB-ARC PF00931.17 EWC45624.1 - 0.16 10.7 0.1 4.1 6.1 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain Ribosomal_L39 PF00832.15 EWC45625.1 - 2.5e-21 74.8 9.6 2.8e-21 74.6 6.7 1.1 1 0 0 1 1 1 1 Ribosomal L39 protein REV PF00424.13 EWC45625.1 - 0.75 9.7 4.2 0.75 9.7 2.9 1.1 1 0 0 1 1 1 0 REV protein (anti-repression trans-activator protein) Ytp1 PF10355.4 EWC45626.1 - 1.9e-75 253.6 20.7 1.9e-75 253.6 14.4 1.7 2 0 0 2 2 2 1 Protein of unknown function (Ytp1) DUF2427 PF10348.4 EWC45626.1 - 1.9e-27 94.9 0.8 1.9e-27 94.9 0.6 3.2 5 0 0 5 5 5 1 Domain of unknown function (DUF2427) Pept_tRNA_hydro PF01195.14 EWC45627.1 - 1.3e-31 109.5 0.0 1.9e-31 108.9 0.0 1.2 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase Mito_fiss_reg PF05308.6 EWC45627.1 - 0.037 13.4 5.2 0.067 12.5 3.6 1.4 1 0 0 1 1 1 0 Mitochondrial fission regulator Lamp PF01299.12 EWC45627.1 - 0.87 8.6 4.5 1.4 7.9 3.1 1.2 1 0 0 1 1 1 0 Lysosome-associated membrane glycoprotein (Lamp) Sec8_exocyst PF04048.9 EWC45630.1 - 1e-41 141.8 0.0 3.3e-41 140.2 0.0 1.9 1 0 0 1 1 1 1 Sec8 exocyst complex component specific domain DUF2450 PF10475.4 EWC45630.1 - 2.8e-07 29.7 0.2 6.2e-07 28.6 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function N-terminal domain (DUF2450) DUF2451 PF10474.4 EWC45630.1 - 0.0026 17.5 0.0 0.034 13.9 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function C-terminus (DUF2451) Peptidase_M24 PF00557.19 EWC45631.1 - 5.5e-43 146.9 0.0 8e-43 146.4 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N PF01321.13 EWC45631.1 - 4.2e-25 88.7 0.0 1.1e-22 80.9 0.0 2.7 2 1 0 2 2 2 2 Creatinase/Prolidase N-terminal domain Methyltransf_24 PF13578.1 EWC45632.1 - 2.3e-17 63.7 0.1 2.1e-15 57.4 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_3 PF01596.12 EWC45632.1 - 6.5e-07 28.6 0.0 1.4e-06 27.5 0.0 1.5 1 1 0 1 1 1 1 O-methyltransferase Methyltransf_18 PF12847.2 EWC45632.1 - 1.8e-05 25.2 0.1 0.00032 21.2 0.0 2.1 1 1 1 2 2 2 1 Methyltransferase domain GCD14 PF08704.5 EWC45632.1 - 0.014 14.8 0.0 0.019 14.4 0.0 1.2 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit CmcI PF04989.7 EWC45632.1 - 0.053 12.8 0.0 0.084 12.1 0.0 1.3 1 0 0 1 1 1 0 Cephalosporin hydroxylase Methyltransf_31 PF13847.1 EWC45632.1 - 0.053 13.1 0.0 0.073 12.6 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain DUF3606 PF12244.3 EWC45635.1 - 0.029 14.0 0.4 0.066 12.8 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3606) PolyA_pol_arg_C PF12626.2 EWC45637.1 - 0.0021 17.6 0.6 0.0034 17.0 0.4 1.3 1 0 0 1 1 1 1 Polymerase A arginine-rich C-terminus DUF2613 PF11021.3 EWC45637.1 - 0.029 14.0 0.2 0.055 13.1 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2613) F-box PF00646.28 EWC45638.1 - 1.2e-06 28.0 1.2 1.2e-06 28.0 0.8 1.7 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.2 EWC45638.1 - 7.2e-06 25.6 0.4 1.5e-05 24.6 0.3 1.5 1 0 0 1 1 1 1 F-box-like DUF106 PF01956.11 EWC45640.1 - 5.5 6.4 7.9 35 3.8 5.5 2.0 1 1 0 1 1 1 0 Integral membrane protein DUF106 YwiC PF14256.1 EWC45641.1 - 0.043 13.8 0.0 0.081 13.0 0.0 1.5 1 0 0 1 1 1 0 YwiC-like protein DUF3275 PF11679.3 EWC45642.1 - 1.2 8.7 5.0 0.46 10.0 1.2 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3275) Glu_syn_central PF04898.9 EWC45644.1 - 0.012 14.8 0.2 0.018 14.3 0.1 1.1 1 0 0 1 1 1 0 Glutamate synthase central domain STAT_alpha PF01017.15 EWC45644.1 - 0.029 14.0 1.0 0.046 13.4 0.7 1.2 1 0 0 1 1 1 0 STAT protein, all-alpha domain TauD PF02668.11 EWC45646.1 - 1.4e-43 149.4 0.0 1.6e-43 149.2 0.0 1.0 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Ax_dynein_light PF10211.4 EWC45646.1 - 0.076 12.8 0.0 0.13 12.1 0.0 1.2 1 0 0 1 1 1 0 Axonemal dynein light chain Plasmod_MYXSPDY PF07981.6 EWC45646.1 - 0.15 11.7 0.7 0.26 11.0 0.5 1.4 1 0 0 1 1 1 0 Plasmodium repeat_MYXSPDY Myb_DNA-bind_6 PF13921.1 EWC45647.1 - 1.7e-05 24.8 0.0 4.1e-05 23.5 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 EWC45647.1 - 3.6e-05 23.7 0.1 0.001 19.0 0.0 2.4 2 0 0 2 2 2 1 Myb-like DNA-binding domain Rap1_C PF11626.3 EWC45647.1 - 0.074 12.9 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain Myb_DNA-bind_2 PF08914.6 EWC45647.1 - 0.1 12.4 0.0 0.21 11.4 0.0 1.5 1 0 0 1 1 1 0 Rap1 Myb domain Glyco_transf_15 PF01793.11 EWC45647.1 - 0.19 10.6 0.7 0.24 10.2 0.5 1.1 1 0 0 1 1 1 0 Glycolipid 2-alpha-mannosyltransferase CAP PF00188.21 EWC45648.1 - 1.6e-17 64.1 2.9 1.6e-17 64.1 2.0 1.6 2 0 0 2 2 2 1 Cysteine-rich secretory protein family zf-C3HC4 PF00097.20 EWC45649.1 - 0.58 9.8 5.9 1.7 8.4 4.1 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EWC45649.1 - 1.7 8.4 8.7 3.8 7.3 6.0 1.6 1 0 0 1 1 1 0 zinc-RING finger domain IBR PF01485.16 EWC45650.1 - 1.9e-07 30.8 22.6 2.4e-05 24.1 6.7 3.5 3 1 0 3 3 3 2 IBR domain PRP21_like_P PF12230.3 EWC45650.1 - 6.8 6.1 9.3 0.79 9.1 0.8 2.7 3 0 0 3 3 3 0 Pre-mRNA splicing factor PRP21 like protein IBR PF01485.16 EWC45651.1 - 1.2e-07 31.4 36.6 1.1e-05 25.2 8.2 3.8 3 1 0 3 3 3 2 IBR domain zf-C3HC4 PF00097.20 EWC45651.1 - 0.0033 17.0 8.3 0.0033 17.0 5.7 3.9 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EWC45651.1 - 0.0044 16.8 8.9 0.0044 16.8 6.2 3.8 2 1 1 3 3 3 1 Ring finger domain Cript PF10235.4 EWC45651.1 - 0.0059 16.9 4.1 0.0059 16.9 2.9 4.7 4 2 1 5 5 5 1 Microtubule-associated protein CRIPT zf-RING_5 PF14634.1 EWC45651.1 - 0.016 14.9 8.5 0.016 14.9 5.9 3.7 3 1 0 3 3 3 0 zinc-RING finger domain zf-C3HC4_2 PF13923.1 EWC45651.1 - 0.019 15.0 8.8 0.019 15.0 6.1 4.1 3 2 1 4 4 4 0 Zinc finger, C3HC4 type (RING finger) Zn_Tnp_IS91 PF14319.1 EWC45651.1 - 5.2 6.6 24.3 0.24 10.9 1.2 3.7 3 0 0 3 3 3 0 Transposase zinc-binding domain MFS_1 PF07690.11 EWC45653.1 - 1.6e-23 82.9 20.5 1.6e-23 82.9 14.2 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily Nodulin-like PF06813.8 EWC45653.1 - 2.2e-11 43.5 4.4 2.2e-11 43.5 3.0 2.4 2 1 0 2 2 2 1 Nodulin-like Beta-TrCP_D PF12125.3 EWC45654.1 - 0.11 12.0 0.6 0.39 10.3 0.1 2.1 3 0 0 3 3 3 0 D domain of beta-TrCP CFEM PF05730.6 EWC45655.1 - 4.3e-10 39.2 8.7 6.6e-10 38.6 6.0 1.3 1 0 0 1 1 1 1 CFEM domain SKG6 PF08693.5 EWC45655.1 - 0.029 13.6 1.0 0.029 13.6 0.7 2.1 2 0 0 2 2 2 0 Transmembrane alpha-helix domain Sporozoite_P67 PF05642.6 EWC45655.1 - 0.07 10.9 6.6 0.077 10.8 4.6 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Rifin_STEVOR PF02009.11 EWC45655.1 - 0.085 12.4 0.0 0.14 11.7 0.0 1.4 1 1 0 1 1 1 0 Rifin/stevor family Syndecan PF01034.15 EWC45655.1 - 0.11 12.1 0.4 0.2 11.3 0.3 1.4 1 0 0 1 1 1 0 Syndecan domain DUF2273 PF10031.4 EWC45655.1 - 0.27 10.8 5.5 0.62 9.7 3.8 1.5 1 0 0 1 1 1 0 Small integral membrane protein (DUF2273) DUF1180 PF06679.7 EWC45655.1 - 0.33 10.8 1.9 0.51 10.2 1.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) ADH_N PF08240.7 EWC45656.1 - 3.1e-27 94.4 2.0 6.8e-27 93.3 1.4 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 EWC45656.1 - 6.9e-11 41.8 0.2 8.4e-08 31.8 0.0 3.0 3 0 0 3 3 3 2 Zinc-binding dehydrogenase ADH_N_assoc PF13823.1 EWC45656.1 - 0.00044 19.8 0.4 0.0009 18.8 0.2 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-associated 2-Hacid_dh_C PF02826.14 EWC45656.1 - 0.11 11.6 0.0 0.24 10.5 0.0 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain adh_short PF00106.20 EWC45657.1 - 7.7e-26 90.9 0.9 2.5e-25 89.3 0.1 2.1 2 1 0 2 2 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EWC45657.1 - 6.5e-20 71.9 0.6 1.1e-19 71.2 0.4 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EWC45657.1 - 7.2e-09 35.5 0.3 1.3e-07 31.4 0.2 2.1 1 1 0 1 1 1 1 KR domain Pyr_redox PF00070.22 EWC45657.1 - 9e-05 22.8 0.2 0.00022 21.5 0.2 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.13 EWC45657.1 - 0.00048 19.8 1.0 0.0012 18.5 0.7 1.7 1 1 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Epimerase PF01370.16 EWC45657.1 - 0.00087 18.7 0.2 0.0047 16.3 0.1 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.8 EWC45657.1 - 0.001 18.3 0.2 0.0017 17.6 0.1 1.3 1 0 0 1 1 1 1 NmrA-like family Polysacc_synt_2 PF02719.10 EWC45657.1 - 0.0012 17.8 0.1 0.0022 16.9 0.1 1.4 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Glyco_tran_WecB PF03808.8 EWC45657.1 - 0.0017 17.8 0.0 0.0029 17.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase WecB/TagA/CpsF family NAD_Gly3P_dh_N PF01210.18 EWC45657.1 - 0.0046 16.7 0.1 0.046 13.4 0.0 2.1 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus DUF1776 PF08643.5 EWC45657.1 - 0.011 14.9 0.0 0.018 14.1 0.0 1.3 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) NAD_binding_10 PF13460.1 EWC45657.1 - 0.016 15.2 0.0 0.029 14.3 0.0 1.4 1 0 0 1 1 1 0 NADH(P)-binding TrkA_N PF02254.13 EWC45657.1 - 0.027 14.4 0.2 0.045 13.7 0.1 1.3 1 0 0 1 1 1 0 TrkA-N domain Methyltransf_25 PF13649.1 EWC45657.1 - 0.039 14.3 0.0 0.063 13.6 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain YjeF_N PF03853.10 EWC45657.1 - 0.051 13.1 0.0 0.077 12.6 0.0 1.4 1 0 0 1 1 1 0 YjeF-related protein N-terminus Shikimate_DH PF01488.15 EWC45657.1 - 0.055 13.5 0.2 0.12 12.4 0.1 1.6 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase HI0933_like PF03486.9 EWC45657.1 - 0.12 10.8 1.5 0.33 9.3 0.7 1.8 2 0 0 2 2 2 0 HI0933-like protein AlaDh_PNT_C PF01262.16 EWC45657.1 - 0.13 11.8 0.7 0.28 10.7 0.1 1.7 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain ARL6IP6 PF15062.1 EWC45657.1 - 0.14 12.1 0.0 0.26 11.1 0.0 1.4 1 0 0 1 1 1 0 Haemopoietic lineage transmembrane helix DUF1628 PF07790.6 EWC45658.1 - 0.0015 19.2 0.7 0.0036 18.0 0.5 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1628) UvdE PF03851.9 EWC45659.1 - 8.9e-81 270.9 0.0 5.3e-58 196.2 0.0 2.2 1 1 1 2 2 2 2 UV-endonuclease UvdE Herpes_gE PF02480.11 EWC45660.1 - 0.0073 14.6 0.0 0.0098 14.2 0.0 1.1 1 0 0 1 1 1 1 Alphaherpesvirus glycoprotein E Peptidase_S8 PF00082.17 EWC45661.1 - 1.5e-33 116.2 3.1 2.3e-33 115.5 2.1 1.3 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.11 EWC45661.1 - 0.11 13.1 0.0 0.19 12.3 0.0 1.4 1 0 0 1 1 1 0 Peptidase inhibitor I9 Ank_2 PF12796.2 EWC45662.1 - 1.2e-26 92.8 0.0 4.2e-12 46.2 0.0 4.2 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.25 EWC45662.1 - 2.1e-25 87.1 5.6 0.0003 20.4 0.0 6.8 6 0 0 6 6 6 5 Ankyrin repeat Ank_3 PF13606.1 EWC45662.1 - 4.1e-19 66.7 0.1 0.0034 17.4 0.0 7.3 6 0 0 6 6 6 4 Ankyrin repeat Ank_4 PF13637.1 EWC45662.1 - 3.6e-18 65.5 1.2 0.0006 20.2 0.0 6.1 4 2 2 6 6 5 4 Ankyrin repeats (many copies) Ank_5 PF13857.1 EWC45662.1 - 4.5e-14 52.1 5.7 0.0074 16.5 0.1 6.5 5 1 0 5 5 5 4 Ankyrin repeats (many copies) PNP_UDP_1 PF01048.15 EWC45662.1 - 5.7e-08 32.0 0.1 3e-07 29.6 0.0 2.2 2 0 0 2 2 2 1 Phosphorylase superfamily NACHT PF05729.7 EWC45662.1 - 1.7e-07 31.0 0.0 3.3e-07 30.1 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.1 EWC45662.1 - 0.00025 21.0 0.1 0.0015 18.5 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 EWC45662.1 - 0.0037 17.4 0.0 0.0099 16.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 EWC45662.1 - 0.0078 15.9 0.0 0.11 12.3 0.0 2.7 2 0 0 2 2 2 1 Part of AAA domain RVP PF00077.15 EWC45662.1 - 0.015 15.2 0.0 8.2 6.4 0.0 3.7 3 0 0 3 3 3 0 Retroviral aspartyl protease AAA_30 PF13604.1 EWC45662.1 - 0.027 14.0 0.0 0.057 12.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_10 PF12846.2 EWC45662.1 - 0.039 13.4 0.0 0.25 10.7 0.0 2.3 2 1 1 3 3 3 0 AAA-like domain RNA_helicase PF00910.17 EWC45662.1 - 0.082 13.0 0.1 0.32 11.1 0.0 2.0 2 0 0 2 2 2 0 RNA helicase KAP_NTPase PF07693.9 EWC45662.1 - 0.11 11.4 2.2 0.9 8.4 0.3 2.2 1 1 1 2 2 2 0 KAP family P-loop domain NB-ARC PF00931.17 EWC45662.1 - 0.22 10.3 0.0 0.42 9.4 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain Arch_ATPase PF01637.13 EWC45662.1 - 0.22 11.1 0.0 0.41 10.3 0.0 1.3 1 0 0 1 1 1 0 Archaeal ATPase FIVAR PF07554.8 EWC45663.1 - 0.039 14.1 0.1 0.12 12.6 0.0 1.9 1 0 0 1 1 1 0 Uncharacterised Sugar-binding Domain Pirin PF02678.11 EWC45664.1 - 7.1e-29 99.8 0.1 1.2e-28 99.0 0.1 1.4 1 0 0 1 1 1 1 Pirin Pirin_C PF05726.8 EWC45664.1 - 1.9e-25 88.8 0.0 6.1e-25 87.3 0.0 1.8 2 0 0 2 2 2 1 Pirin C-terminal cupin domain Cupin_2 PF07883.6 EWC45664.1 - 0.015 14.7 0.7 0.15 11.6 0.3 2.3 2 0 0 2 2 2 0 Cupin domain IPK PF03770.11 EWC45665.1 - 1.4e-49 168.4 0.0 3.3e-49 167.2 0.0 1.7 1 0 0 1 1 1 1 Inositol polyphosphate kinase TFIID_30kDa PF03540.8 EWC45666.1 - 2.3e-27 94.5 0.3 3.5e-27 93.9 0.2 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit SNARE_assoc PF09335.6 EWC45668.1 - 0.046 13.9 0.7 0.11 12.6 0.5 1.6 1 0 0 1 1 1 0 SNARE associated Golgi protein Iron_permease PF04120.7 EWC45668.1 - 0.17 11.4 0.1 0.29 10.6 0.1 1.3 1 0 0 1 1 1 0 Low affinity iron permease MFS_1 PF07690.11 EWC45669.1 - 1.1e-20 73.7 52.6 2.9e-20 72.2 36.5 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.8 EWC45669.1 - 4.8e-10 38.2 14.1 4.8e-10 38.2 9.7 2.0 1 1 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) RRM_1 PF00076.17 EWC45670.1 - 1.3e-13 50.4 0.0 2.1e-13 49.6 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EWC45670.1 - 1e-07 31.8 0.0 1.8e-07 31.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.1 EWC45670.1 - 4.4e-06 27.0 3.4 4.4e-06 27.0 2.4 2.8 2 1 1 3 3 3 1 C-terminal duplication domain of Friend of PRMT1 RRM_5 PF13893.1 EWC45670.1 - 3.4e-05 23.6 0.1 5.6e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Gly-rich_Ago1 PF12764.2 EWC45670.1 - 0.0025 18.4 3.0 0.0025 18.4 2.1 1.8 2 0 0 2 2 2 1 Glycine-rich region of argonaut Ribosomal_60s PF00428.14 EWC45670.1 - 2 8.8 13.7 12 6.3 2.3 3.2 3 0 0 3 3 3 0 60s Acidic ribosomal protein MFS_1 PF07690.11 EWC45671.1 - 1.8e-45 155.2 30.5 2.2e-45 154.9 21.1 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EWC45671.1 - 4.5e-09 35.3 16.8 1.1e-08 34.1 11.3 1.9 1 1 0 1 1 1 1 Sugar (and other) transporter TRI12 PF06609.8 EWC45671.1 - 6.4e-09 34.5 3.3 9.6e-09 33.9 2.3 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF2178 PF09946.4 EWC45671.1 - 0.0013 18.4 0.5 0.0013 18.4 0.3 2.1 2 0 0 2 2 2 1 Predicted membrane protein (DUF2178) zf-CCCH PF00642.19 EWC45673.1 - 0.00018 21.1 0.7 0.00018 21.1 0.5 2.3 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF2826 PF11442.3 EWC45673.1 - 0.14 11.8 0.1 0.22 11.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2826) Smg4_UPF3 PF03467.10 EWC45674.1 - 9.6e-23 81.0 0.0 4.9e-22 78.7 0.0 2.1 1 1 0 1 1 1 1 Smg-4/UPF3 family Med19 PF10278.4 EWC45674.1 - 0.82 9.3 10.7 0.21 11.2 4.3 2.0 2 0 0 2 2 2 0 Mediator of RNA pol II transcription subunit 19 Pyridox_oxidase PF01243.15 EWC45675.1 - 0.013 15.4 0.0 0.023 14.6 0.0 1.5 1 0 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase Metallophos PF00149.23 EWC45676.1 - 5.8e-42 143.3 0.2 8e-42 142.9 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase FAM104 PF15434.1 EWC45676.1 - 0.79 9.9 4.6 2.2 8.5 3.2 1.6 1 0 0 1 1 1 0 Family 104 Zn_clus PF00172.13 EWC45677.1 - 0.00037 20.3 7.0 0.00059 19.7 4.8 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF1412 PF07203.6 EWC45677.1 - 0.081 12.8 0.0 0.25 11.2 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1412) Cript PF10235.4 EWC45677.1 - 6.7 7.1 8.9 0.68 10.3 2.5 2.0 2 0 0 2 2 2 0 Microtubule-associated protein CRIPT Snf7 PF03357.16 EWC45678.1 - 1.1e-20 73.6 2.2 1.8e-20 73.0 1.5 1.2 1 0 0 1 1 1 1 Snf7 MerR-DNA-bind PF09278.6 EWC45678.1 - 0.0018 18.6 4.7 0.76 10.2 0.3 3.8 4 0 0 4 4 4 2 MerR, DNA binding PBC PF03792.8 EWC45678.1 - 0.034 13.8 0.3 0.06 13.0 0.2 1.5 1 0 0 1 1 1 0 PBC domain CS PF04969.11 EWC45679.1 - 3.6e-07 30.6 0.0 7e-07 29.7 0.0 1.6 1 0 0 1 1 1 1 CS domain Pirin PF02678.11 EWC45680.1 - 6.8e-29 99.8 0.0 1.5e-28 98.7 0.0 1.6 1 0 0 1 1 1 1 Pirin Cupin_2 PF07883.6 EWC45680.1 - 2.5e-06 26.8 0.9 0.00041 19.7 0.1 2.3 2 0 0 2 2 2 2 Cupin domain adh_short PF00106.20 EWC45682.1 - 4.6e-11 42.9 0.0 2e-10 40.8 0.0 1.9 2 0 0 2 2 2 1 short chain dehydrogenase DUF1972 PF09314.6 EWC45682.1 - 0.0016 17.9 0.0 0.085 12.3 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF1972) Polysacc_synt_2 PF02719.10 EWC45682.1 - 0.012 14.4 0.0 0.067 12.0 0.0 1.9 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein WD40 PF00400.27 EWC45684.1 - 0.00025 20.8 1.5 0.02 14.7 0.2 2.9 2 0 0 2 2 2 2 WD domain, G-beta repeat PQQ_2 PF13360.1 EWC45684.1 - 0.04 13.3 2.1 0.12 11.8 0.0 2.5 3 0 0 3 3 3 0 PQQ-like domain Ferric_reduct PF01794.14 EWC45685.1 - 8.2e-19 67.9 15.5 8.2e-19 67.9 10.7 2.6 3 0 0 3 3 3 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.7 EWC45685.1 - 2.7e-07 30.4 0.0 0.00013 21.8 0.0 2.7 1 1 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.7 EWC45685.1 - 2.2e-06 27.6 0.1 0.03 14.2 0.0 2.5 1 1 1 2 2 2 2 Ferric reductase NAD binding domain NAD_binding_1 PF00175.16 EWC45685.1 - 0.00076 20.0 0.0 0.01 16.3 0.0 2.4 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain Imm28 PF15574.1 EWC45686.1 - 0.11 12.1 0.0 0.97 9.0 0.0 2.1 2 0 0 2 2 2 0 Immunity protein 28 PRMT5 PF05185.11 EWC45687.1 - 3.4e-157 523.9 0.0 4.2e-157 523.6 0.0 1.1 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase KOW PF00467.24 EWC45690.1 - 1.8e-08 33.7 1.1 1.8e-08 33.7 0.8 1.9 2 0 0 2 2 2 1 KOW motif Ribosomal_S19 PF00203.16 EWC45691.1 - 6.4e-23 80.1 0.0 9e-23 79.6 0.0 1.3 1 1 0 1 1 1 1 Ribosomal protein S19 Mre11_DNA_bind PF04152.9 EWC45692.1 - 1.4e-54 184.5 1.0 3.2e-54 183.4 0.7 1.6 1 0 0 1 1 1 1 Mre11 DNA-binding presumed domain Metallophos PF00149.23 EWC45692.1 - 6.8e-25 87.6 1.8 1e-24 87.0 1.3 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 EWC45692.1 - 1.2e-05 25.1 0.0 6.4e-05 22.8 0.0 2.3 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain PBP1_TM PF14812.1 EWC45692.1 - 2 8.8 19.2 1 9.6 3.5 3.2 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Peptidase_M43 PF05572.8 EWC45694.1 - 2.6e-15 56.3 0.4 4e-15 55.7 0.3 1.2 1 0 0 1 1 1 1 Pregnancy-associated plasma protein-A Reprolysin_2 PF13574.1 EWC45694.1 - 0.00012 22.2 0.0 0.00018 21.6 0.0 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M7 PF02031.11 EWC45694.1 - 0.0022 17.7 0.2 0.0051 16.5 0.1 1.7 2 0 0 2 2 2 1 Streptomyces extracellular neutral proteinase (M7) family Reprolysin_5 PF13688.1 EWC45694.1 - 0.0029 17.5 0.3 0.005 16.8 0.2 1.5 1 1 0 1 1 1 1 Metallo-peptidase family M12 Peptidase_M10 PF00413.19 EWC45694.1 - 0.0048 16.6 0.0 0.0083 15.8 0.0 1.4 1 0 0 1 1 1 1 Matrixin DUF4573 PF15140.1 EWC45694.1 - 0.0097 15.5 5.6 0.016 14.8 3.9 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4573) Reprolysin_3 PF13582.1 EWC45694.1 - 0.023 15.1 0.2 0.041 14.4 0.1 1.5 1 1 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.1 EWC45694.1 - 0.029 13.8 0.1 0.058 12.9 0.0 1.5 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like Glycos_transf_1 PF00534.15 EWC45695.1 - 1.1e-30 106.3 0.0 6.1e-29 100.6 0.0 2.2 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.1 EWC45695.1 - 2.7e-10 40.5 0.0 2.4e-08 34.1 0.0 3.0 2 1 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.1 EWC45695.1 - 1.8e-07 31.0 0.0 3.5e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_2 PF13524.1 EWC45695.1 - 6e-06 26.4 0.0 6.3e-05 23.1 0.0 2.4 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.1 EWC45695.1 - 3e-05 24.2 0.0 6.7e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Zn_clus PF00172.13 EWC45697.1 - 1.5e-05 24.8 26.9 0.01 15.7 8.2 2.3 2 0 0 2 2 2 2 Fungal Zn(2)-Cys(6) binuclear cluster domain Acyl_transf_3 PF01757.17 EWC45699.1 - 2.1e-34 118.8 24.8 2.5e-33 115.3 17.2 2.5 1 1 0 1 1 1 1 Acyltransferase family Cuticle_2 PF08184.6 EWC45699.1 - 0.0094 15.7 3.1 0.097 12.4 2.1 2.3 2 0 0 2 2 2 1 Cuticle protein 7 isoform family AA_permease_C PF13906.1 EWC45699.1 - 0.3 10.9 5.4 1.2 9.0 0.1 3.5 3 0 0 3 3 3 0 C-terminus of AA_permease ADH_zinc_N PF00107.21 EWC45700.1 - 2.5e-08 33.5 0.2 4.5e-08 32.6 0.2 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 EWC45700.1 - 2.9e-07 30.2 0.0 1.6e-06 27.8 0.0 2.1 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ELFV_dehydrog PF00208.16 EWC45700.1 - 0.038 13.5 0.1 0.058 12.9 0.1 1.3 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase AlaDh_PNT_C PF01262.16 EWC45700.1 - 0.069 12.7 0.2 0.16 11.5 0.0 1.7 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain TRF PF08558.5 EWC45701.1 - 9.8e-63 211.6 0.1 1.5e-62 211.1 0.0 1.2 1 0 0 1 1 1 1 Telomere repeat binding factor (TRF) Myb_DNA-binding PF00249.26 EWC45701.1 - 0.0023 17.9 0.0 0.0049 16.8 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Porin_3 PF01459.17 EWC45703.1 - 7.6e-54 182.8 4.2 8.9e-54 182.6 2.9 1.0 1 0 0 1 1 1 1 Eukaryotic porin KdpC PF02669.10 EWC45703.1 - 0.03 13.9 0.1 0.055 13.1 0.0 1.4 1 0 0 1 1 1 0 K+-transporting ATPase, c chain OMP_b-brl PF13505.1 EWC45703.1 - 0.17 11.7 7.2 0.67 9.8 5.0 2.0 1 1 0 1 1 1 0 Outer membrane protein beta-barrel domain Lyase_1 PF00206.15 EWC45705.1 - 1.4e-19 70.4 0.0 2.4e-19 69.6 0.0 1.3 1 0 0 1 1 1 1 Lyase ADSL_C PF10397.4 EWC45705.1 - 1e-13 51.0 0.0 3.2e-13 49.4 0.0 1.9 1 0 0 1 1 1 1 Adenylosuccinate lyase C-terminus TMEM247 PF15444.1 EWC45705.1 - 0.2 11.4 1.3 0.37 10.5 0.0 1.9 2 0 0 2 2 2 0 Transmembrane protein 247 Mpp10 PF04006.7 EWC45706.1 - 2e-70 237.8 0.6 2.4e-69 234.3 0.4 2.0 1 1 0 1 1 1 1 Mpp10 protein Ribosom_S12_S23 PF00164.20 EWC45707.1 - 7.4e-41 138.3 0.3 8.5e-41 138.2 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Pex19 PF04614.7 EWC45708.1 - 8.4e-67 225.3 9.3 8.4e-67 225.3 6.5 2.0 1 1 0 2 2 2 1 Pex19 protein family ATG_C PF09333.6 EWC45708.1 - 0.067 13.3 0.0 0.22 11.6 0.0 1.9 2 0 0 2 2 2 0 ATG C terminal domain RXT2_N PF08595.6 EWC45708.1 - 1.2 8.9 5.0 0.25 11.1 1.0 1.7 2 0 0 2 2 2 0 RXT2-like, N-terminal cwf18 PF08315.7 EWC45709.1 - 3.4e-30 105.1 3.9 3.4e-30 105.1 2.7 1.9 2 0 0 2 2 2 1 cwf18 pre-mRNA splicing factor ABC1 PF03109.11 EWC45710.1 - 1.7e-10 40.8 0.1 1.6e-05 24.8 0.0 2.5 1 1 1 2 2 2 2 ABC1 family RIO1 PF01163.17 EWC45710.1 - 0.042 13.2 0.0 0.13 11.6 0.0 1.7 2 0 0 2 2 2 0 RIO1 family APH PF01636.18 EWC45710.1 - 0.077 12.7 0.6 0.35 10.5 0.4 1.9 1 1 0 1 1 1 0 Phosphotransferase enzyme family Gasdermin PF04598.7 EWC45711.1 - 0.034 12.9 0.6 0.055 12.2 0.4 1.2 1 0 0 1 1 1 0 Gasdermin family PPI_Ypi1 PF07491.6 EWC45712.1 - 8.6e-12 44.5 0.1 1.4e-11 43.8 0.1 1.3 1 0 0 1 1 1 1 Protein phosphatase inhibitor MRP-S25 PF13741.1 EWC45713.1 - 3.1e-75 252.6 2.9 1.8e-74 250.0 2.0 1.8 1 1 0 1 1 1 1 Mitochondrial ribosomal protein S25 MRP-S23 PF10484.4 EWC45713.1 - 0.00057 19.7 0.7 0.024 14.5 0.5 2.6 1 1 0 1 1 1 1 Mitochondrial ribosomal protein S23 TFIID-18kDa PF02269.11 EWC45714.1 - 2.4e-31 107.3 0.2 2.8e-31 107.1 0.1 1.0 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit CENP-S PF15630.1 EWC45714.1 - 6.3e-06 26.2 0.0 1.1e-05 25.4 0.0 1.4 1 0 0 1 1 1 1 Kinetochore component CENP-S Bromo_TP PF07524.8 EWC45714.1 - 1.4e-05 24.6 0.0 2.2e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Bromodomain associated Histone PF00125.19 EWC45714.1 - 6e-05 23.0 0.0 0.0001 22.3 0.0 1.4 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TAF PF02969.12 EWC45714.1 - 0.00039 20.3 0.7 0.00065 19.6 0.1 1.5 2 0 0 2 2 2 1 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.18 EWC45714.1 - 0.00046 20.1 1.6 0.00058 19.8 0.4 1.7 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.10 EWC45714.1 - 0.13 12.0 0.1 0.17 11.6 0.1 1.3 1 1 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit DUF1253 PF06862.7 EWC45715.1 - 4.3e-145 483.4 0.0 5e-145 483.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1253) Ufd2P_core PF10408.4 EWC45716.1 - 1e-186 621.9 0.0 1.4e-186 621.5 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin elongating factor core U-box PF04564.10 EWC45716.1 - 1.1e-24 86.2 0.7 3e-24 84.7 0.5 1.9 1 0 0 1 1 1 1 U-box domain Sod_Fe_N PF00081.17 EWC45716.1 - 0.097 12.9 0.8 1.8 8.8 0.1 3.0 2 1 1 3 3 3 0 Iron/manganese superoxide dismutases, alpha-hairpin domain Syntaxin PF00804.20 EWC45716.1 - 0.97 9.6 7.8 19 5.4 0.2 3.9 4 0 0 4 4 4 0 Syntaxin Ras PF00071.17 EWC45717.1 - 3.3e-56 189.1 0.0 3.8e-56 188.9 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EWC45717.1 - 4.4e-16 59.4 0.0 7.6e-16 58.6 0.0 1.4 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EWC45717.1 - 7.7e-07 28.5 0.0 1.2e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.5 EWC45717.1 - 0.0018 17.5 0.0 0.0027 16.9 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.7 EWC45717.1 - 0.041 13.0 0.0 0.05 12.7 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region PduV-EutP PF10662.4 EWC45717.1 - 0.058 12.8 0.0 11 5.5 0.0 2.6 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Rtt106 PF08512.7 EWC45718.1 - 9.5e-26 89.6 0.0 1.6e-25 88.8 0.0 1.4 1 0 0 1 1 1 1 Histone chaperone Rttp106-like DUF2457 PF10446.4 EWC45718.1 - 0.25 10.0 14.7 0.36 9.5 10.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Asp PF00026.18 EWC45719.1 - 3.7e-64 216.9 0.3 4.5e-64 216.7 0.2 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 EWC45719.1 - 1.6e-10 41.2 0.3 1.5e-09 37.9 0.2 2.3 2 0 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.1 EWC45719.1 - 2.3e-08 34.4 0.2 0.00038 20.8 0.1 2.9 2 1 0 2 2 2 2 Aspartyl protease DUF1777 PF08648.7 EWC45721.1 - 0.00012 21.8 39.5 0.00016 21.4 27.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1777) MIP-T3 PF10243.4 EWC45721.1 - 0.012 14.1 8.4 0.013 14.0 5.8 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 DUF3827 PF12877.2 EWC45721.1 - 1.6 6.7 7.9 2.1 6.3 5.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) KH_1 PF00013.24 EWC45722.1 - 1.7e-08 33.9 0.0 3.4e-08 33.0 0.0 1.5 1 0 0 1 1 1 1 KH domain KH_3 PF13014.1 EWC45722.1 - 0.00012 21.5 0.1 0.00028 20.4 0.0 1.6 1 0 0 1 1 1 1 KH domain UPF0181 PF03701.9 EWC45722.1 - 0.038 13.2 0.1 0.12 11.6 0.1 1.8 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0181) DUF2277 PF10041.4 EWC45722.1 - 0.15 12.0 0.0 0.32 10.9 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2277) Totivirus_coat PF05518.6 EWC45722.1 - 6 4.5 11.2 9.2 3.9 7.8 1.3 1 0 0 1 1 1 0 Totivirus coat protein ALS_ss_C PF10369.4 EWC45723.1 - 4.2e-19 68.0 0.0 8.5e-18 63.8 0.0 2.2 2 0 0 2 2 2 1 Small subunit of acetolactate synthase ACT PF01842.20 EWC45723.1 - 1.5e-11 43.5 0.1 2.6e-11 42.7 0.1 1.4 1 0 0 1 1 1 1 ACT domain ACT_5 PF13710.1 EWC45723.1 - 1.2e-08 34.5 0.0 2.6e-08 33.5 0.0 1.6 1 0 0 1 1 1 1 ACT domain DUF1949 PF09186.6 EWC45723.1 - 0.0094 15.5 0.0 1.4 8.5 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF1949) ACT_6 PF13740.1 EWC45723.1 - 0.038 13.7 0.1 8 6.2 0.0 2.6 2 0 0 2 2 2 0 ACT domain DUF3712 PF12505.3 EWC45724.1 - 0.0049 16.9 0.2 0.014 15.4 0.1 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3712) OTCace_N PF02729.16 EWC45725.1 - 2.7e-43 147.0 0.1 3.9e-43 146.5 0.1 1.2 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain OTCace PF00185.19 EWC45725.1 - 1.1e-40 139.1 0.0 1.6e-40 138.5 0.0 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain Ribosomal_L17 PF01196.14 EWC45726.1 - 3.1e-31 107.8 0.0 4.8e-31 107.2 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L17 Ribosomal_L32p PF01783.18 EWC45727.1 - 6e-14 51.9 1.8 7.7e-14 51.6 1.2 1.2 1 0 0 1 1 1 1 Ribosomal L32p protein family zf-TFIIB PF13453.1 EWC45727.1 - 0.019 14.1 0.5 0.58 9.3 0.0 2.2 2 0 0 2 2 2 0 Transcription factor zinc-finger zf-FPG_IleRS PF06827.9 EWC45727.1 - 0.44 10.2 5.3 1.1 8.9 3.6 1.7 1 1 0 1 1 1 0 Zinc finger found in FPG and IleRS Septin PF00735.13 EWC45728.1 - 2e-112 374.8 0.3 2.3e-112 374.6 0.2 1.0 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.18 EWC45728.1 - 6.2e-07 29.3 0.0 1.3e-06 28.3 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.11 EWC45728.1 - 4.2e-06 26.0 0.0 7.1e-06 25.2 0.0 1.4 1 0 0 1 1 1 1 AIG1 family DUF258 PF03193.11 EWC45728.1 - 3.6e-05 23.0 0.0 6.5e-05 22.1 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Dynamin_N PF00350.18 EWC45728.1 - 0.00054 19.8 0.5 1.3 8.8 0.0 2.5 1 1 1 2 2 2 2 Dynamin family GTP_EFTU PF00009.22 EWC45728.1 - 0.0007 19.0 0.3 0.017 14.5 0.0 2.3 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_10 PF12846.2 EWC45728.1 - 0.0034 16.8 0.1 0.0034 16.8 0.1 1.3 1 1 0 1 1 1 1 AAA-like domain AAA_23 PF13476.1 EWC45728.1 - 0.011 16.0 0.0 0.023 15.0 0.0 1.4 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.1 EWC45728.1 - 0.011 15.8 0.0 0.029 14.4 0.0 1.7 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.22 EWC45728.1 - 0.012 15.8 0.2 0.021 15.1 0.1 1.6 1 1 0 1 1 1 0 ABC transporter AAA_16 PF13191.1 EWC45728.1 - 0.018 15.0 0.0 0.039 13.9 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain NB-ARC PF00931.17 EWC45728.1 - 0.024 13.5 0.0 0.042 12.6 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain T2SE PF00437.15 EWC45728.1 - 0.027 13.3 0.1 0.081 11.8 0.0 1.7 2 0 0 2 2 2 0 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.13 EWC45728.1 - 0.037 13.5 0.0 0.067 12.6 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family Gtr1_RagA PF04670.7 EWC45728.1 - 0.038 13.1 0.1 0.13 11.3 0.0 1.9 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region AAA_29 PF13555.1 EWC45728.1 - 0.13 11.7 0.0 0.32 10.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_17 PF13207.1 EWC45728.1 - 0.43 11.3 1.9 25 5.7 1.3 2.5 1 1 0 1 1 1 0 AAA domain Guanylate_kin PF00625.16 EWC45729.1 - 3.9e-58 195.9 0.0 4.7e-58 195.6 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase AAA_16 PF13191.1 EWC45729.1 - 1.2e-07 31.9 0.1 2.2e-07 31.0 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.1 EWC45729.1 - 5e-07 29.6 0.0 1.3e-06 28.3 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.1 EWC45729.1 - 3.9e-06 27.0 0.0 0.00012 22.2 0.0 2.2 2 0 0 2 2 2 1 AAA domain DUF258 PF03193.11 EWC45729.1 - 1.4e-05 24.3 0.0 4.5e-05 22.6 0.0 1.8 1 1 0 1 1 1 1 Protein of unknown function, DUF258 AAA_17 PF13207.1 EWC45729.1 - 5.7e-05 23.9 0.0 8e-05 23.4 0.0 1.6 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.22 EWC45729.1 - 0.00014 22.1 0.0 0.00017 21.9 0.0 1.5 1 1 0 1 1 1 1 ABC transporter AAA_18 PF13238.1 EWC45729.1 - 0.00026 21.2 0.0 0.0022 18.2 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.1 EWC45729.1 - 0.0014 18.1 0.2 0.0033 16.9 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_28 PF13521.1 EWC45729.1 - 0.0019 18.2 0.0 0.0033 17.3 0.0 1.5 2 0 0 2 2 1 1 AAA domain AAA_14 PF13173.1 EWC45729.1 - 0.0027 17.5 0.0 0.0052 16.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain CPT PF07931.7 EWC45729.1 - 0.0042 16.7 0.0 0.0088 15.6 0.0 1.5 1 1 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein cobW PF02492.14 EWC45729.1 - 0.0073 15.7 0.1 0.017 14.5 0.0 1.7 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_10 PF12846.2 EWC45729.1 - 0.0084 15.5 0.4 0.018 14.4 0.1 1.5 1 1 0 2 2 2 1 AAA-like domain AAA_19 PF13245.1 EWC45729.1 - 0.011 15.4 0.0 0.029 14.0 0.0 1.7 1 0 0 1 1 1 0 Part of AAA domain RNA_helicase PF00910.17 EWC45729.1 - 0.013 15.6 0.0 0.027 14.6 0.0 1.6 1 0 0 1 1 1 0 RNA helicase NACHT PF05729.7 EWC45729.1 - 0.017 14.7 0.0 0.055 13.1 0.0 1.8 2 0 0 2 2 2 0 NACHT domain AAA PF00004.24 EWC45729.1 - 0.018 15.2 0.1 0.48 10.6 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.1 EWC45729.1 - 0.019 15.2 0.5 0.022 15.0 0.3 1.5 1 1 0 1 1 1 0 AAA domain Rad17 PF03215.10 EWC45729.1 - 0.023 13.3 0.0 0.03 13.0 0.0 1.2 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein ArgK PF03308.11 EWC45729.1 - 0.025 13.3 0.0 0.04 12.6 0.0 1.3 1 1 0 1 1 1 0 ArgK protein MMR_HSR1 PF01926.18 EWC45729.1 - 0.026 14.4 0.0 0.034 14.0 0.0 1.6 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_30 PF13604.1 EWC45729.1 - 0.028 14.0 0.0 0.045 13.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain UPF0079 PF02367.12 EWC45729.1 - 0.035 13.7 0.0 0.072 12.7 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 Arch_ATPase PF01637.13 EWC45729.1 - 0.038 13.6 0.0 0.057 13.1 0.0 1.4 1 0 0 1 1 1 0 Archaeal ATPase Zeta_toxin PF06414.7 EWC45729.1 - 0.039 13.0 0.0 0.072 12.1 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin NB-ARC PF00931.17 EWC45729.1 - 0.041 12.7 0.0 0.064 12.1 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain Miro PF08477.8 EWC45729.1 - 0.059 13.8 0.0 0.12 12.8 0.0 1.8 1 1 0 1 1 1 0 Miro-like protein T2SE PF00437.15 EWC45729.1 - 0.06 12.2 0.0 0.1 11.4 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_5 PF07728.9 EWC45729.1 - 0.068 12.8 0.0 0.35 10.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Adeno_IVa2 PF02456.10 EWC45729.1 - 0.085 11.4 0.0 0.12 10.9 0.0 1.1 1 0 0 1 1 1 0 Adenovirus IVa2 protein AAA_25 PF13481.1 EWC45729.1 - 0.1 12.0 0.2 0.51 9.7 0.0 2.0 2 1 0 2 2 2 0 AAA domain NTPase_1 PF03266.10 EWC45729.1 - 0.13 11.9 0.0 0.23 11.1 0.0 1.5 1 0 0 1 1 1 0 NTPase AAA_24 PF13479.1 EWC45729.1 - 0.13 11.7 0.1 0.26 10.8 0.1 1.6 1 1 1 2 2 2 0 AAA domain Rad52_Rad22 PF04098.10 EWC45730.1 - 7.1e-47 158.9 0.0 2.3e-46 157.3 0.0 1.7 2 0 0 2 2 2 1 Rad52/22 family double-strand break repair protein rRNA_proc-arch PF13234.1 EWC45731.1 - 6.1e-103 343.6 0.1 1.2e-102 342.6 0.0 1.6 2 0 0 2 2 2 1 rRNA-processing arch domain DSHCT PF08148.7 EWC45731.1 - 7.8e-59 197.9 3.1 2.2e-58 196.4 2.2 1.8 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.24 EWC45731.1 - 8.7e-23 80.6 0.1 2.4e-22 79.1 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EWC45731.1 - 3.1e-07 30.1 0.0 7.7e-07 28.8 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain COX7C PF02935.11 EWC45732.1 - 2.2e-15 56.2 0.6 2.9e-15 55.8 0.4 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIIc IKI3 PF04762.7 EWC45733.1 - 2.3e-282 939.1 0.0 2.9e-282 938.7 0.0 1.1 1 0 0 1 1 1 1 IKI3 family WD40 PF00400.27 EWC45733.1 - 0.005 16.6 1.2 0.23 11.4 0.0 3.4 4 0 0 4 4 4 1 WD domain, G-beta repeat TctA PF01970.11 EWC45734.1 - 0.01 14.2 1.1 0.012 14.0 0.8 1.1 1 0 0 1 1 1 0 Tripartite tricarboxylate transporter TctA family GHMP_kinases_N PF00288.21 EWC45735.1 - 1.5e-09 37.8 0.5 1.5e-09 37.8 0.3 2.3 3 0 0 3 3 3 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.8 EWC45735.1 - 0.0027 17.8 0.0 0.0071 16.5 0.0 1.7 1 0 0 1 1 1 1 GHMP kinases C terminal Dicer_dimer PF03368.9 EWC45735.1 - 0.021 14.5 0.0 1.3 8.8 0.0 2.5 2 0 0 2 2 2 0 Dicer dimerisation domain Cyto_heme_lyase PF01265.12 EWC45736.1 - 1.3e-77 260.8 4.0 9.3e-74 248.2 0.3 2.0 1 1 1 2 2 2 2 Cytochrome c/c1 heme lyase Ndc1_Nup PF09531.5 EWC45737.1 - 1.1e-91 308.1 0.2 1.4e-91 307.8 0.2 1.1 1 0 0 1 1 1 1 Nucleoporin protein Ndc1-Nup MOZART1 PF12554.3 EWC45738.1 - 1.1e-26 91.9 1.2 1.3e-26 91.7 0.8 1.1 1 0 0 1 1 1 1 Mitotic-spindle organizing gamma-tubulin ring associated SRP54_N PF02881.14 EWC45738.1 - 0.0047 17.0 0.1 0.012 15.7 0.1 1.7 1 1 0 1 1 1 1 SRP54-type protein, helical bundle domain PNPase_C PF12111.3 EWC45738.1 - 0.27 10.4 2.1 0.4 9.9 1.5 1.2 1 0 0 1 1 1 0 Polyribonucleotide phosphorylase C terminal Rrn6 PF10214.4 EWC45739.1 - 2.1e-06 26.1 0.2 2.3e-06 26.0 0.1 1.0 1 0 0 1 1 1 1 RNA polymerase I-specific transcription-initiation factor CRM1_C PF08767.6 EWC45741.1 - 2.9e-130 433.8 0.2 2.9e-130 433.8 0.1 2.8 3 0 0 3 3 3 1 CRM1 C terminal Xpo1 PF08389.7 EWC45741.1 - 3.7e-40 137.2 9.7 1.4e-39 135.3 3.8 3.8 4 0 0 4 4 4 1 Exportin 1-like protein IBN_N PF03810.14 EWC45741.1 - 1.5e-10 40.8 0.7 7.1e-10 38.6 0.0 2.5 2 0 0 2 2 2 1 Importin-beta N-terminal domain DUF3385 PF11865.3 EWC45741.1 - 0.076 12.9 2.6 0.38 10.6 0.0 3.3 4 0 0 4 4 4 0 Domain of unknown function (DUF3385) Ank_2 PF12796.2 EWC45743.1 - 7.5e-33 112.7 6.7 6.6e-13 48.8 0.1 4.4 4 1 1 5 5 5 3 Ankyrin repeats (3 copies) SPX PF03105.14 EWC45743.1 - 1.5e-31 110.2 4.0 4e-17 62.8 0.2 2.4 1 1 1 2 2 2 2 SPX domain Ank_4 PF13637.1 EWC45743.1 - 1.6e-25 88.9 4.3 6.4e-12 45.6 0.0 4.3 4 0 0 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.25 EWC45743.1 - 1.4e-22 78.2 13.4 0.0013 18.3 0.2 7.2 7 0 0 7 7 7 5 Ankyrin repeat Ank_3 PF13606.1 EWC45743.1 - 2.7e-17 61.1 14.8 0.0049 16.9 0.0 7.8 9 0 0 9 9 8 5 Ankyrin repeat Ank_5 PF13857.1 EWC45743.1 - 3.1e-15 55.8 9.3 1.1e-05 25.4 0.1 6.6 1 1 6 7 7 7 5 Ankyrin repeats (many copies) GDPD PF03009.12 EWC45743.1 - 1.7e-07 31.0 0.0 3.6e-07 29.9 0.0 1.5 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family TMEM154 PF15102.1 EWC45743.1 - 0.00011 21.8 0.2 0.00029 20.5 0.2 1.6 1 0 0 1 1 1 1 TMEM154 protein family SKG6 PF08693.5 EWC45743.1 - 0.0022 17.2 0.7 0.0044 16.2 0.5 1.5 1 0 0 1 1 1 1 Transmembrane alpha-helix domain DUF4448 PF14610.1 EWC45743.1 - 0.0086 15.5 0.1 0.016 14.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) DUF3754 PF12576.3 EWC45743.1 - 0.058 13.0 0.0 3.8 7.1 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3754) Coa1 PF08695.5 EWC45744.1 - 4.9e-33 113.1 0.0 6.1e-33 112.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 zinc_ribbon_6 PF14599.1 EWC45745.1 - 1.2e-24 85.8 4.7 1.8e-24 85.2 3.3 1.3 1 0 0 1 1 1 1 Zinc-ribbon zf-CHY PF05495.7 EWC45746.1 - 2.2e-12 46.9 5.1 3.8e-12 46.1 3.5 1.3 1 0 0 1 1 1 1 CHY zinc finger Complex1_LYR PF05347.10 EWC45747.1 - 2.4e-05 24.0 1.3 5e-05 23.0 0.9 1.5 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 EWC45747.1 - 0.04 14.1 1.3 0.05 13.8 0.9 1.4 1 1 0 1 1 1 0 Complex1_LYR-like DPBB_1 PF03330.13 EWC45748.1 - 1.6e-08 34.4 0.0 3.3e-08 33.3 0.0 1.5 1 1 0 1 1 1 1 Rare lipoprotein A (RlpA)-like double-psi beta-barrel Barwin PF00967.12 EWC45748.1 - 0.0034 17.0 0.0 0.0046 16.6 0.0 1.2 1 0 0 1 1 1 1 Barwin family AAA PF00004.24 EWC45749.1 - 5.9e-94 311.2 0.0 9.3e-48 161.7 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 EWC45749.1 - 1.8e-14 53.3 0.0 1.7e-06 27.2 0.0 2.7 3 0 0 3 3 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_16 PF13191.1 EWC45749.1 - 2.5e-13 50.4 0.7 0.00036 20.5 0.0 4.6 2 2 1 3 3 3 2 AAA ATPase domain AAA_22 PF13401.1 EWC45749.1 - 5.5e-13 49.1 0.2 0.00033 20.8 0.0 4.4 2 2 0 2 2 2 2 AAA domain AAA_5 PF07728.9 EWC45749.1 - 7.1e-13 48.4 0.0 1.9e-05 24.3 0.0 3.3 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_17 PF13207.1 EWC45749.1 - 1.5e-12 48.4 0.0 1.8e-05 25.5 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_14 PF13173.1 EWC45749.1 - 3.3e-12 46.4 0.0 0.00011 22.0 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_2 PF07724.9 EWC45749.1 - 8.1e-12 45.3 0.0 0.00022 21.1 0.0 2.7 2 1 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_33 PF13671.1 EWC45749.1 - 2e-10 40.6 0.0 0.00023 21.0 0.0 2.6 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.17 EWC45749.1 - 6.4e-10 39.1 0.0 9.4e-05 22.5 0.0 2.7 2 1 0 2 2 2 2 RNA helicase AAA_28 PF13521.1 EWC45749.1 - 2.8e-09 37.1 0.0 0.00027 20.9 0.0 2.7 3 0 0 3 3 2 2 AAA domain AAA_19 PF13245.1 EWC45749.1 - 1.3e-08 34.4 0.9 0.0017 18.0 0.0 3.2 3 0 0 3 3 2 2 Part of AAA domain Zeta_toxin PF06414.7 EWC45749.1 - 2e-08 33.5 0.6 0.0017 17.4 0.0 2.8 3 0 0 3 3 3 2 Zeta toxin IstB_IS21 PF01695.12 EWC45749.1 - 4.9e-08 32.6 0.0 0.011 15.1 0.0 2.4 2 0 0 2 2 2 2 IstB-like ATP binding protein NACHT PF05729.7 EWC45749.1 - 5.3e-08 32.6 0.2 0.03 13.9 0.0 3.8 3 1 0 4 4 4 2 NACHT domain TIP49 PF06068.8 EWC45749.1 - 6.4e-08 31.7 0.1 0.0016 17.2 0.0 2.5 2 0 0 2 2 2 2 TIP49 C-terminus Mg_chelatase PF01078.16 EWC45749.1 - 1.4e-07 30.9 0.8 0.014 14.6 0.1 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_18 PF13238.1 EWC45749.1 - 2.7e-07 30.9 0.0 0.02 15.1 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_3 PF07726.6 EWC45749.1 - 4.5e-07 29.5 0.0 0.0023 17.5 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.1 EWC45749.1 - 4.6e-07 29.4 9.5 0.16 11.3 0.0 4.8 3 2 2 5 5 5 3 AAA domain Viral_helicase1 PF01443.13 EWC45749.1 - 6e-06 25.9 0.0 0.027 14.0 0.0 2.3 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase ATP-synt_ab PF00006.20 EWC45749.1 - 7.9e-06 25.5 0.0 0.028 13.9 0.0 2.3 2 0 0 2 2 2 2 ATP synthase alpha/beta family, nucleotide-binding domain Arch_ATPase PF01637.13 EWC45749.1 - 1.2e-05 25.1 0.0 0.13 11.9 0.0 3.9 2 2 2 4 4 4 1 Archaeal ATPase NB-ARC PF00931.17 EWC45749.1 - 2.2e-05 23.4 0.0 0.1 11.4 0.0 2.5 2 0 0 2 2 2 2 NB-ARC domain Sigma54_activat PF00158.21 EWC45749.1 - 3.3e-05 23.4 0.0 0.25 10.8 0.0 3.2 2 1 0 2 2 2 2 Sigma-54 interaction domain ABC_tran PF00005.22 EWC45749.1 - 3.5e-05 24.1 0.0 0.32 11.2 0.0 2.7 2 0 0 2 2 2 2 ABC transporter Sigma54_activ_2 PF14532.1 EWC45749.1 - 5.4e-05 23.2 0.0 0.48 10.4 0.0 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain KaiC PF06745.8 EWC45749.1 - 0.00013 21.1 0.5 0.47 9.5 0.0 3.1 2 1 0 3 3 3 2 KaiC Cytidylate_kin2 PF13189.1 EWC45749.1 - 0.00016 21.6 0.0 0.084 12.7 0.0 2.4 2 0 0 2 2 2 1 Cytidylate kinase-like family Parvo_NS1 PF01057.12 EWC45749.1 - 0.00045 19.1 0.1 0.6 8.9 0.0 2.2 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 PhoH PF02562.11 EWC45749.1 - 0.00048 19.4 0.8 1.3 8.1 0.0 3.1 4 0 0 4 4 3 2 PhoH-like protein SKI PF01202.17 EWC45749.1 - 0.00067 19.5 0.0 1.1 9.1 0.0 2.6 2 0 0 2 2 2 1 Shikimate kinase AAA_24 PF13479.1 EWC45749.1 - 0.00068 19.2 0.0 0.12 11.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain Rad17 PF03215.10 EWC45749.1 - 0.001 17.8 0.0 0.84 8.2 0.0 2.2 2 0 0 2 2 2 2 Rad17 cell cycle checkpoint protein UPF0079 PF02367.12 EWC45749.1 - 0.0026 17.4 0.0 1.8 8.1 0.0 2.4 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 AAA_10 PF12846.2 EWC45749.1 - 0.0036 16.7 2.1 4.2 6.7 0.0 4.3 6 0 0 6 6 4 0 AAA-like domain Bac_DnaA PF00308.13 EWC45749.1 - 0.0041 16.8 0.0 0.32 10.6 0.0 2.6 2 0 0 2 2 2 1 Bacterial dnaA protein CPT PF07931.7 EWC45749.1 - 0.0076 15.8 0.1 1.3 8.5 0.0 3.0 3 0 0 3 3 3 1 Chloramphenicol phosphotransferase-like protein DUF815 PF05673.8 EWC45749.1 - 0.0081 15.1 0.0 0.12 11.3 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF815) NTPase_1 PF03266.10 EWC45749.1 - 0.0091 15.7 0.2 2.5 7.7 0.0 3.4 4 0 0 4 4 3 1 NTPase KAP_NTPase PF07693.9 EWC45749.1 - 0.011 14.7 0.0 0.15 10.9 0.0 2.5 2 1 0 2 2 2 0 KAP family P-loop domain ResIII PF04851.10 EWC45749.1 - 0.013 15.3 0.0 4.6 7.0 0.0 2.4 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit T2SE PF00437.15 EWC45749.1 - 0.026 13.4 0.0 6.6 5.5 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein DUF2075 PF09848.4 EWC45749.1 - 0.027 13.4 0.0 6.5 5.6 0.0 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_23 PF13476.1 EWC45749.1 - 0.028 14.7 0.0 2.5 8.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_11 PF13086.1 EWC45749.1 - 0.034 13.7 0.2 4.8 6.6 0.0 2.6 3 0 0 3 3 2 0 AAA domain PduV-EutP PF10662.4 EWC45749.1 - 0.045 13.2 0.0 7.3 6.0 0.0 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation DAP3 PF10236.4 EWC45749.1 - 0.083 11.8 0.0 13 4.6 0.0 2.4 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 cobW PF02492.14 EWC45749.1 - 0.087 12.2 0.1 13 5.1 0.0 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain IPT PF01745.11 EWC45749.1 - 0.11 11.5 0.0 5.4 6.1 0.0 2.3 2 0 0 2 2 2 0 Isopentenyl transferase FeoB_N PF02421.13 EWC45749.1 - 0.2 10.9 0.4 9.4 5.5 0.0 2.6 3 0 0 3 3 2 0 Ferrous iron transport protein B Snf7 PF03357.16 EWC45750.1 - 6.1e-32 110.3 14.7 6.1e-32 110.3 10.2 1.3 2 0 0 2 2 2 1 Snf7 DUF2746 PF10874.3 EWC45750.1 - 0.036 14.2 0.5 0.13 12.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2746) Mito_carr PF00153.22 EWC45751.1 - 9.6e-32 108.5 1.1 5e-16 58.1 0.0 2.3 2 0 0 2 2 2 2 Mitochondrial carrier protein HECT PF00632.20 EWC45753.1 - 6.5e-93 311.3 0.0 9.3e-93 310.8 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.21 EWC45753.1 - 5.7e-34 115.5 20.6 1.5e-11 43.8 3.2 3.8 3 0 0 3 3 3 3 WW domain C2 PF00168.25 EWC45753.1 - 3.4e-16 58.8 0.3 8.9e-16 57.5 0.2 1.8 1 0 0 1 1 1 1 C2 domain RRM_1 PF00076.17 EWC45754.1 - 3e-06 26.7 0.0 5.2e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EWC45754.1 - 0.00012 22.0 0.0 0.00021 21.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) DUF972 PF06156.8 EWC45754.1 - 0.0031 17.8 0.7 0.0036 17.6 0.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF972) V_ATPase_I PF01496.14 EWC45754.1 - 0.0032 15.4 0.2 0.0033 15.3 0.1 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family IncA PF04156.9 EWC45754.1 - 0.012 15.1 0.7 0.014 15.0 0.5 1.1 1 0 0 1 1 1 0 IncA protein DUF4201 PF13870.1 EWC45754.1 - 0.018 14.4 1.6 0.023 14.1 1.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) APG6 PF04111.7 EWC45754.1 - 0.03 13.3 1.2 0.03 13.3 0.8 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF904 PF06005.7 EWC45754.1 - 0.032 14.5 5.4 0.053 13.8 3.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF904) CASP_C PF08172.7 EWC45754.1 - 0.034 13.1 0.1 0.043 12.8 0.1 1.1 1 0 0 1 1 1 0 CASP C terminal DivIC PF04977.10 EWC45754.1 - 0.052 13.0 5.5 0.073 12.5 3.8 1.2 1 0 0 1 1 1 0 Septum formation initiator Fmp27_WPPW PF10359.4 EWC45754.1 - 0.067 11.6 1.0 0.076 11.4 0.7 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Flagellin_C PF00700.16 EWC45754.1 - 0.075 13.1 0.2 0.11 12.7 0.2 1.2 1 0 0 1 1 1 0 Bacterial flagellin C-terminal helical region DUF2151 PF10221.4 EWC45754.1 - 0.14 10.2 2.5 0.15 10.1 1.7 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator PEARLI-4 PF05278.7 EWC45754.1 - 0.18 11.1 2.1 0.21 10.9 1.5 1.1 1 0 0 1 1 1 0 Arabidopsis phospholipase-like protein (PEARLI 4) DUF724 PF05266.9 EWC45754.1 - 0.2 11.2 4.5 0.26 10.8 3.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF724) MMPL PF03176.10 EWC45754.1 - 0.2 10.3 0.5 0.23 10.1 0.4 1.0 1 0 0 1 1 1 0 MMPL family FlaC_arch PF05377.6 EWC45754.1 - 0.25 11.2 2.1 0.45 10.4 1.5 1.4 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) DUF4337 PF14235.1 EWC45754.1 - 0.32 10.8 2.2 0.39 10.5 1.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) TMF_DNA_bd PF12329.3 EWC45754.1 - 0.43 10.4 7.4 0.53 10.1 5.2 1.1 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding Spc24 PF08286.6 EWC45754.1 - 0.74 9.5 4.6 1.1 9.0 3.2 1.2 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 DUF3782 PF12644.2 EWC45754.1 - 1.1 9.0 4.3 20 5.0 3.0 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF3782) Dynactin_p62 PF05502.8 EWC45755.1 - 0.5 9.0 12.8 3.6 6.2 0.1 2.3 2 0 0 2 2 2 0 Dynactin p62 family IncA PF04156.9 EWC45755.1 - 3.6 7.1 23.9 2.5 7.6 2.1 2.9 2 1 1 3 3 3 0 IncA protein NIF PF03031.13 EWC45756.1 - 6.2e-12 45.4 0.0 1.2e-11 44.5 0.0 1.4 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase AhpC-TSA PF00578.16 EWC45757.1 - 9e-26 89.9 0.0 1.4e-25 89.3 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 EWC45757.1 - 2.3e-17 62.8 0.0 4.3e-17 62.0 0.0 1.4 1 0 0 1 1 1 1 Redoxin CDC45 PF02724.9 EWC45757.1 - 6.4 4.6 5.7 11 3.9 3.9 1.3 1 0 0 1 1 1 0 CDC45-like protein PRELI PF04707.9 EWC45758.1 - 6.4e-46 155.7 0.0 7.3e-46 155.5 0.0 1.0 1 0 0 1 1 1 1 PRELI-like family Spindle_Spc25 PF08234.7 EWC45759.1 - 7.8e-19 67.4 0.9 2.1e-18 66.0 0.0 2.2 3 0 0 3 3 3 1 Chromosome segregation protein Spc25 ERM PF00769.14 EWC45759.1 - 0.00081 18.9 10.0 0.00096 18.7 6.9 1.3 1 0 0 1 1 1 1 Ezrin/radixin/moesin family DUF536 PF04394.9 EWC45759.1 - 0.00095 18.8 2.9 0.00095 18.8 2.0 2.5 2 1 0 2 2 2 1 Protein of unknown function, DUF536 THOC7 PF05615.8 EWC45759.1 - 0.0045 17.2 8.7 0.0091 16.2 6.0 1.6 1 0 0 1 1 1 1 Tho complex subunit 7 AAA_13 PF13166.1 EWC45759.1 - 0.0059 15.1 11.3 0.0078 14.7 7.8 1.1 1 0 0 1 1 1 1 AAA domain LMBR1 PF04791.11 EWC45759.1 - 0.0097 14.5 2.6 0.0098 14.5 1.8 1.1 1 0 0 1 1 1 1 LMBR1-like membrane protein APG6 PF04111.7 EWC45759.1 - 0.036 13.1 16.7 0.055 12.4 11.6 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 Cortex-I_coil PF09304.5 EWC45759.1 - 0.25 11.4 13.9 0.58 10.2 9.6 1.8 1 1 0 1 1 1 0 Cortexillin I, coiled coil V_ATPase_I PF01496.14 EWC45759.1 - 0.57 7.9 5.3 0.57 7.9 3.7 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Seryl_tRNA_N PF02403.17 EWC45759.1 - 3.8 7.5 20.1 0.92 9.5 1.9 2.7 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Atg14 PF10186.4 EWC45759.1 - 4.4 6.1 13.7 7 5.4 9.5 1.3 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Mgr1 PF08602.5 EWC45759.1 - 5 6.0 7.8 7.8 5.3 5.4 1.3 1 0 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit Ribosomal_L3 PF00297.17 EWC45760.1 - 6.3e-31 107.7 0.3 1.8e-30 106.2 0.2 1.6 1 1 0 1 1 1 1 Ribosomal protein L3 CUE PF02845.11 EWC45761.1 - 1.3e-11 43.7 0.0 2.1e-11 43.0 0.0 1.4 1 0 0 1 1 1 1 CUE domain Shugoshin_C PF07557.6 EWC45762.1 - 1.4e-06 27.6 1.5 1.4e-06 27.6 1.1 4.1 4 0 0 4 4 4 1 Shugoshin C terminus Shugoshin_N PF07558.6 EWC45762.1 - 0.00022 20.8 6.2 0.00067 19.3 4.3 1.9 1 0 0 1 1 1 1 Shugoshin N-terminal coiled-coil region DUF641 PF04859.7 EWC45762.1 - 0.061 13.0 5.2 0.21 11.3 2.1 2.6 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) Mod_r PF07200.8 EWC45762.1 - 0.33 10.8 8.5 0.35 10.7 4.3 2.1 2 1 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein DivIC PF04977.10 EWC45762.1 - 0.98 8.9 7.0 0.8 9.2 2.3 2.7 2 1 1 3 3 3 0 Septum formation initiator DASH_Dad2 PF08654.5 EWC45763.1 - 2.6e-23 81.9 3.7 7.9e-23 80.4 2.6 1.7 1 1 0 1 1 1 1 DASH complex subunit Dad2 YPEB PF14620.1 EWC45763.1 - 0.047 12.7 0.1 0.052 12.5 0.1 1.1 1 0 0 1 1 1 0 YpeB sporulation SM-ATX PF14438.1 EWC45764.1 - 4.5e-14 52.1 0.0 9.7e-14 51.0 0.0 1.6 1 0 0 1 1 1 1 Ataxin 2 SM domain LsmAD PF06741.8 EWC45764.1 - 5.7e-12 45.5 2.2 3.1e-05 23.9 0.1 2.7 1 1 1 2 2 2 2 LsmAD domain AIP3 PF03915.8 EWC45765.1 - 1.7e-133 445.6 4.4 2.3e-133 445.1 3.0 1.2 1 0 0 1 1 1 1 Actin interacting protein 3 Syntaxin_2 PF14523.1 EWC45765.1 - 0.0084 16.1 15.2 1.1 9.3 0.1 4.9 4 1 1 5 5 5 2 Syntaxin-like protein Uds1 PF15456.1 EWC45765.1 - 0.0093 15.9 2.7 0.021 14.7 0.2 2.8 2 1 0 2 2 2 1 Up-regulated During Septation Baculo_PEP_C PF04513.7 EWC45765.1 - 0.015 15.1 2.5 9.9 5.9 0.1 4.2 4 1 0 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus HALZ PF02183.13 EWC45765.1 - 0.072 12.8 7.2 0.5 10.1 0.3 3.6 3 0 0 3 3 3 0 Homeobox associated leucine zipper DUF948 PF06103.6 EWC45765.1 - 0.43 10.4 8.5 21 5.0 0.0 4.9 4 1 0 4 4 4 0 Bacterial protein of unknown function (DUF948) AAA_13 PF13166.1 EWC45765.1 - 0.43 8.9 7.2 1.5 7.1 0.4 2.7 1 1 2 3 3 3 0 AAA domain CorA PF01544.13 EWC45765.1 - 1.7 7.5 8.8 0.24 10.3 1.9 2.5 3 1 0 3 3 3 0 CorA-like Mg2+ transporter protein LPP PF04728.8 EWC45765.1 - 2 8.2 6.7 0.33 10.7 0.5 2.9 3 0 0 3 3 3 0 Lipoprotein leucine-zipper Transcrip_act PF04949.8 EWC45765.1 - 4.8 6.7 10.8 5.3 6.6 0.0 3.6 4 0 0 4 4 4 0 Transcriptional activator Pkinase PF00069.20 EWC45766.1 - 5.5e-12 45.3 0.0 8.2e-12 44.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain HEAT PF02985.17 EWC45766.1 - 2.8e-11 42.4 2.6 0.078 13.1 0.0 6.3 5 0 0 5 5 5 2 HEAT repeat Pkinase_Tyr PF07714.12 EWC45766.1 - 5.9e-07 28.8 0.0 1.1e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase HEAT_2 PF13646.1 EWC45766.1 - 1.2e-05 25.4 0.2 0.0055 16.9 0.1 3.3 3 0 0 3 3 3 1 HEAT repeats Kinase-like PF14531.1 EWC45766.1 - 0.012 14.5 0.0 0.019 13.9 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Adaptin_N PF01602.15 EWC45766.1 - 0.048 11.9 0.0 0.46 8.7 0.0 1.9 1 1 1 2 2 2 0 Adaptin N terminal region Cnd1 PF12717.2 EWC45766.1 - 0.062 13.1 0.0 0.24 11.2 0.0 1.9 1 1 1 2 2 2 0 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.1 EWC45766.1 - 5.5 7.6 5.6 30 5.2 0.1 3.5 3 1 0 3 3 3 0 HEAT-like repeat MoaE PF02391.12 EWC45767.1 - 2.6e-27 94.9 0.0 4e-27 94.3 0.0 1.3 1 0 0 1 1 1 1 MoaE protein BaxI_1 PF12811.2 EWC45767.1 - 0.16 11.1 0.0 0.21 10.7 0.0 1.1 1 0 0 1 1 1 0 Bax inhibitor 1 like DUF4646 PF15496.1 EWC45767.1 - 0.17 11.9 0.2 8.4 6.4 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4646) Pkinase PF00069.20 EWC45769.1 - 3.1e-36 124.8 0.0 4.3e-36 124.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC45769.1 - 2.4e-14 53.0 0.0 3.4e-14 52.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 EWC45769.1 - 0.014 15.1 0.0 0.55 9.9 0.0 2.4 1 1 1 2 2 2 0 Phosphotransferase enzyme family DUF605 PF04652.11 EWC45769.1 - 0.97 8.7 14.4 1.4 8.2 10.0 1.2 1 0 0 1 1 1 0 Vta1 like SARG PF15385.1 EWC45769.1 - 1.5 8.1 13.4 2.3 7.5 9.3 1.2 1 0 0 1 1 1 0 Specifically androgen-regulated gene protein Nucleoporin_C PF03177.9 EWC45770.1 - 3.2e-57 194.3 3.1 5.4e-57 193.6 2.2 1.2 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal Nucleoporin_N PF08801.6 EWC45770.1 - 1.8e-39 135.7 0.0 2.4e-39 135.3 0.0 1.2 1 0 0 1 1 1 1 Nup133 N terminal like CIAPIN1 PF05093.8 EWC45771.1 - 3.7e-36 123.2 3.7 6e-36 122.5 2.6 1.3 1 0 0 1 1 1 1 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis HABP4_PAI-RBP1 PF04774.10 EWC45772.1 - 5.6e-05 23.6 2.5 0.00013 22.4 1.7 1.8 1 1 0 1 1 1 1 Hyaluronan / mRNA binding family Arylesterase PF01731.15 EWC45773.1 - 4.9e-08 32.8 0.0 1.2e-07 31.6 0.0 1.6 1 0 0 1 1 1 1 Arylesterase Ribosomal_L7Ae PF01248.21 EWC45774.1 - 2.4e-23 81.4 4.6 1.3e-22 79.1 0.4 2.2 2 0 0 2 2 2 2 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family KAR PF15222.1 EWC45774.1 - 0.032 14.3 0.0 0.37 10.8 0.0 2.2 2 0 0 2 2 2 0 Kidney androgen-regulated Moulting_cycle PF04870.11 EWC45774.1 - 0.098 11.7 1.4 0.24 10.4 0.1 2.0 2 0 0 2 2 2 0 Moulting cycle FGGY_C PF02782.11 EWC45775.1 - 2.1e-73 246.1 0.4 4.1e-73 245.2 0.3 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.16 EWC45775.1 - 2.5e-58 197.2 0.0 3.5e-58 196.7 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain Peptidase_M41 PF01434.13 EWC45776.1 - 4.7e-73 245.1 1.7 4.7e-73 245.1 1.2 1.7 2 0 0 2 2 2 1 Peptidase family M41 AAA PF00004.24 EWC45776.1 - 1.3e-40 138.6 0.0 3.1e-40 137.4 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) TIP49 PF06068.8 EWC45776.1 - 1.3e-05 24.1 0.1 4e-05 22.5 0.0 1.9 2 0 0 2 2 2 1 TIP49 C-terminus AAA_16 PF13191.1 EWC45776.1 - 1.8e-05 24.7 3.8 0.00017 21.6 0.6 3.6 2 1 0 2 2 2 1 AAA ATPase domain AAA_17 PF13207.1 EWC45776.1 - 4.1e-05 24.3 0.0 0.00011 22.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.9 EWC45776.1 - 4.7e-05 23.1 0.0 0.00019 21.1 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.7 EWC45776.1 - 0.00027 20.0 0.0 0.00098 18.2 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_19 PF13245.1 EWC45776.1 - 0.0007 19.3 0.1 0.0022 17.6 0.1 1.9 1 0 0 1 1 1 1 Part of AAA domain AAA_25 PF13481.1 EWC45776.1 - 0.0009 18.6 2.0 0.059 12.7 0.3 2.7 1 1 1 2 2 2 1 AAA domain AAA_22 PF13401.1 EWC45776.1 - 0.0011 19.1 0.9 0.026 14.6 0.1 3.1 2 1 0 2 2 2 1 AAA domain IstB_IS21 PF01695.12 EWC45776.1 - 0.0014 18.0 0.0 0.0039 16.6 0.0 1.8 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_33 PF13671.1 EWC45776.1 - 0.0019 18.0 0.0 0.0049 16.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 EWC45776.1 - 0.0077 15.3 0.5 0.016 14.3 0.2 1.6 1 1 0 1 1 1 1 Zeta toxin Mg_chelatase PF01078.16 EWC45776.1 - 0.01 15.0 0.1 0.022 13.9 0.1 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_28 PF13521.1 EWC45776.1 - 0.016 15.1 0.0 0.054 13.4 0.0 2.0 1 0 0 1 1 1 0 AAA domain AAA_2 PF07724.9 EWC45776.1 - 0.019 14.9 0.0 0.07 13.0 0.0 2.0 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) Sigma54_activat PF00158.21 EWC45776.1 - 0.022 14.2 0.0 0.61 9.5 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain Sigma54_activ_2 PF14532.1 EWC45776.1 - 0.032 14.3 0.1 0.61 10.1 0.0 2.7 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_18 PF13238.1 EWC45776.1 - 0.037 14.3 0.0 0.15 12.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain NACHT PF05729.7 EWC45776.1 - 0.61 9.7 2.2 0.88 9.2 0.1 2.2 3 0 0 3 3 3 0 NACHT domain RRM_1 PF00076.17 EWC45777.1 - 1.1e-79 261.9 4.4 5.8e-20 70.7 0.1 5.3 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EWC45777.1 - 1.3e-55 185.2 0.5 1.1e-15 57.3 0.0 5.2 5 0 0 5 5 5 5 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EWC45777.1 - 8.3e-41 137.6 0.5 1.6e-09 37.4 0.0 5.3 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.13 EWC45777.1 - 3e-29 100.4 0.2 1.7e-28 98.0 0.1 2.4 2 0 0 2 2 2 1 Poly-adenylate binding protein, unique domain CbiG_mid PF11761.3 EWC45777.1 - 7.1e-05 22.9 0.1 3.4 7.9 0.0 3.7 3 0 0 3 3 3 2 Cobalamin biosynthesis central region Nup35_RRM_2 PF14605.1 EWC45777.1 - 0.00016 21.3 0.0 17 5.2 0.0 4.2 4 0 0 4 4 4 1 Nup53/35/40-type RNA recognition motif Limkain-b1 PF11608.3 EWC45777.1 - 0.00033 20.3 2.4 2.5 7.9 0.0 3.6 3 0 0 3 3 3 2 Limkain b1 OB_RNB PF08206.6 EWC45777.1 - 0.11 11.9 2.8 8.8 5.9 0.0 3.4 3 0 0 3 3 3 0 Ribonuclease B OB domain HECT PF00632.20 EWC45778.1 - 4.8e-80 269.0 0.0 7.5e-80 268.4 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) IQ PF00612.22 EWC45778.1 - 0.00084 18.7 1.9 0.0038 16.7 1.3 2.2 1 0 0 1 1 1 1 IQ calmodulin-binding motif F-box-like PF12937.2 EWC45779.1 - 4.5e-06 26.2 1.0 8.6e-06 25.3 0.7 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EWC45779.1 - 5.1e-06 25.9 0.8 1.1e-05 24.8 0.5 1.6 1 0 0 1 1 1 1 F-box domain WSC PF01822.14 EWC45780.1 - 2.3e-18 65.9 9.0 3e-18 65.4 6.3 1.2 1 0 0 1 1 1 1 WSC domain GMC_oxred_C PF05199.8 EWC45782.1 - 5.9e-26 91.4 0.0 1.5e-25 90.1 0.0 1.8 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_N PF00732.14 EWC45782.1 - 1.1e-21 77.2 0.0 1.2e-20 73.8 0.0 2.6 1 1 0 1 1 1 1 GMC oxidoreductase CBM_1 PF00734.13 EWC45782.1 - 1.1e-09 37.7 9.6 2.9e-09 36.4 6.6 1.8 1 0 0 1 1 1 1 Fungal cellulose binding domain FAD_binding_2 PF00890.19 EWC45782.1 - 2.7e-09 36.3 0.1 1.2e-06 27.6 0.0 2.4 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.19 EWC45782.1 - 3.3e-08 32.8 0.1 0.0004 19.3 0.0 2.5 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EWC45782.1 - 5e-06 26.4 0.2 1.7e-05 24.7 0.1 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 EWC45782.1 - 0.00021 21.2 0.0 0.00054 19.9 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 EWC45782.1 - 0.00031 19.3 0.7 0.00047 18.7 0.0 1.6 2 0 0 2 2 2 1 HI0933-like protein FAD_oxidored PF12831.2 EWC45782.1 - 0.0025 16.9 0.0 0.081 11.9 0.0 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.14 EWC45782.1 - 0.0052 15.8 0.9 0.0071 15.4 0.1 1.6 2 0 0 2 2 2 1 FAD binding domain Thi4 PF01946.12 EWC45782.1 - 0.012 14.6 0.0 0.38 9.8 0.0 2.3 2 0 0 2 2 2 0 Thi4 family Mucin PF01456.12 EWC45782.1 - 0.084 12.6 45.0 0.35 10.6 9.3 2.6 2 0 0 2 2 2 0 Mucin-like glycoprotein LPP20 PF02169.11 EWC45782.1 - 0.15 12.1 7.2 0.52 10.4 0.0 2.6 2 0 0 2 2 2 0 LPP20 lipoprotein IDO PF01231.13 EWC45783.1 - 6.8e-47 159.8 0.0 9.3e-47 159.3 0.0 1.2 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase Nucleos_tra2_C PF07662.8 EWC45784.1 - 1.6e-70 236.8 0.4 1.6e-70 236.8 0.3 2.3 2 0 0 2 2 2 1 Na+ dependent nucleoside transporter C-terminus Nucleos_tra2_N PF01773.15 EWC45784.1 - 2.6e-23 82.1 2.1 2.6e-23 82.1 1.5 2.5 3 0 0 3 3 3 1 Na+ dependent nucleoside transporter N-terminus CN_hydrolase PF00795.17 EWC45785.1 - 3.3e-28 98.2 0.0 7.8e-28 97.0 0.0 1.7 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Nucleopor_Nup85 PF07575.8 EWC45785.1 - 1.5e-21 76.2 0.0 6e-13 47.8 0.0 2.7 2 1 0 2 2 2 2 Nup85 Nucleoporin ATG2_CAD PF13329.1 EWC45786.1 - 7.8e-33 113.2 0.3 2.4e-32 111.6 0.2 1.9 1 0 0 1 1 1 1 Autophagy-related protein 2 CAD motif ATG_C PF09333.6 EWC45786.1 - 1.8e-25 88.9 0.1 6.6e-25 87.1 0.1 2.1 1 0 0 1 1 1 1 ATG C terminal domain Med11 PF10280.4 EWC45787.1 - 0.12 12.3 0.0 0.23 11.5 0.0 1.4 1 0 0 1 1 1 0 Mediator complex protein SCP2 PF02036.12 EWC45788.1 - 2.3e-22 79.2 0.5 2.7e-22 78.9 0.3 1.1 1 0 0 1 1 1 1 SCP-2 sterol transfer family Alkyl_sulf_C PF14864.1 EWC45788.1 - 8.1e-05 22.6 0.1 0.00012 22.1 0.1 1.5 1 1 0 1 1 1 1 Alkyl sulfatase C-terminal Nucleoporin_FG PF13634.1 EWC45789.1 - 5.7e-18 65.2 193.5 0.00011 22.4 17.4 8.3 3 3 4 7 7 7 6 Nucleoporin FG repeat region NUP50 PF08911.6 EWC45789.1 - 2.8e-13 50.0 0.4 2.8e-13 50.0 0.3 4.9 4 0 0 4 4 4 1 NUP50 (Nucleoporin 50 kDa) Ran_BP1 PF00638.13 EWC45789.1 - 4.2e-09 36.5 0.2 6.6e-09 35.8 0.2 1.3 1 0 0 1 1 1 1 RanBP1 domain DUF1129 PF06570.6 EWC45789.1 - 0.49 9.6 0.6 4.4 6.5 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) DUF2457 PF10446.4 EWC45789.1 - 1 8.0 9.3 2 7.0 6.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) NOA36 PF06524.7 EWC45789.1 - 3.5 6.8 3.6 6 6.0 2.5 1.3 1 0 0 1 1 1 0 NOA36 protein Nop14 PF04147.7 EWC45789.1 - 3.6 5.3 5.1 6 4.6 3.5 1.2 1 0 0 1 1 1 0 Nop14-like family HATPase_c PF02518.21 EWC45791.1 - 5.2e-25 87.3 0.0 1.8e-24 85.6 0.0 1.9 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.19 EWC45791.1 - 4.9e-24 84.4 0.1 9.4e-24 83.5 0.1 1.5 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.20 EWC45791.1 - 7.7e-16 57.8 0.1 3.7e-15 55.6 0.0 2.3 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.20 EWC45791.1 - 0.00015 21.8 0.0 0.00052 20.1 0.0 2.0 1 0 0 1 1 1 1 HAMP domain DUF3683 PF12447.3 EWC45791.1 - 0.038 13.8 0.7 1.5 8.7 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3683) ADH_zinc_N PF00107.21 EWC45792.1 - 7.5e-32 109.6 1.3 8.5e-32 109.4 0.3 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 EWC45792.1 - 7.7e-13 49.4 0.0 2e-12 48.1 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.7 EWC45792.1 - 1.2e-06 28.2 0.0 3.4e-06 26.7 0.0 1.8 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain AlaDh_PNT_C PF01262.16 EWC45792.1 - 0.0014 18.2 0.4 0.0023 17.5 0.3 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain HupF_HypC PF01455.13 EWC45792.1 - 0.051 13.5 0.1 0.19 11.7 0.1 2.0 1 1 0 1 1 1 0 HupF/HypC family EMP70 PF02990.11 EWC45793.1 - 6.1e-181 602.4 1.2 7.6e-181 602.1 0.8 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 ADIP PF11559.3 EWC45796.1 - 4.3e-33 114.3 9.6 1e-32 113.1 5.4 2.3 2 0 0 2 2 2 1 Afadin- and alpha -actinin-Binding M16C_assoc PF08367.6 EWC45796.1 - 0.009 14.8 0.2 0.79 8.5 0.1 2.4 2 0 0 2 2 2 2 Peptidase M16C associated bZIP_1 PF00170.16 EWC45796.1 - 0.064 13.2 6.1 0.39 10.7 1.0 3.8 3 1 0 3 3 3 0 bZIP transcription factor IncA PF04156.9 EWC45796.1 - 0.064 12.8 9.5 2.1 7.9 4.6 2.5 2 0 0 2 2 2 0 IncA protein HAUS-augmin3 PF14932.1 EWC45796.1 - 0.96 8.5 11.5 4.1 6.5 3.8 2.7 2 1 0 2 2 2 0 HAUS augmin-like complex subunit 3 DUF3552 PF12072.3 EWC45796.1 - 7.5 5.7 22.5 3.3 6.8 2.3 4.6 2 2 1 5 5 5 0 Domain of unknown function (DUF3552) Arrestin_N PF00339.24 EWC45797.1 - 3.3e-13 49.6 0.0 3.2e-10 40.0 0.0 2.5 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain Pyr_redox_2 PF07992.9 EWC45798.1 - 9.2e-25 87.6 4.7 1.4e-14 54.4 0.1 4.2 2 1 1 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 EWC45798.1 - 2.6e-18 66.1 6.2 1.5e-14 54.1 0.2 3.2 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 EWC45798.1 - 2.5e-14 53.8 0.1 2e-07 31.2 0.0 3.2 1 1 2 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase Rieske PF00355.21 EWC45798.1 - 3.1e-14 52.2 0.0 8.1e-14 50.9 0.0 1.7 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain DAO PF01266.19 EWC45798.1 - 6.6e-11 41.7 2.4 0.0001 21.3 0.0 3.9 3 1 1 4 4 4 3 FAD dependent oxidoreductase K_oxygenase PF13434.1 EWC45798.1 - 1.7e-06 27.1 0.0 0.0093 14.9 0.0 2.7 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.1 EWC45798.1 - 2e-06 27.6 0.6 0.095 12.4 0.0 3.2 3 0 0 3 3 3 2 FAD-NAD(P)-binding NAD_binding_7 PF13241.1 EWC45798.1 - 0.00047 20.3 0.3 0.43 10.8 0.0 2.4 2 0 0 2 2 2 2 Putative NAD(P)-binding Reductase_C PF14759.1 EWC45798.1 - 0.00095 19.4 0.0 0.0029 17.8 0.0 1.8 1 0 0 1 1 1 1 Reductase C-terminal TrkA_N PF02254.13 EWC45798.1 - 0.0059 16.6 0.3 0.96 9.4 0.0 2.5 2 0 0 2 2 2 1 TrkA-N domain HI0933_like PF03486.9 EWC45798.1 - 0.0076 14.7 1.4 1.4 7.3 0.0 2.8 3 1 0 3 3 3 2 HI0933-like protein DUF1188 PF06690.6 EWC45798.1 - 0.0085 15.2 0.1 0.014 14.5 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1188) UDPG_MGDP_dh_N PF03721.9 EWC45798.1 - 0.015 14.7 0.1 0.023 14.0 0.0 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 3HCDH_N PF02737.13 EWC45798.1 - 0.016 14.8 0.4 0.016 14.8 0.2 1.6 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Amino_oxidase PF01593.19 EWC45798.1 - 0.019 14.0 0.1 0.64 9.0 0.0 2.2 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase CPSase_L_chain PF00289.17 EWC45798.1 - 0.069 13.2 0.1 1.7 8.7 0.0 2.7 2 1 0 2 2 2 0 Carbamoyl-phosphate synthase L chain, N-terminal domain NAD_binding_8 PF13450.1 EWC45798.1 - 0.12 12.3 0.3 20 5.2 0.1 2.7 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Shikimate_DH PF01488.15 EWC45798.1 - 0.53 10.3 2.0 2.8 8.0 0.1 2.3 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase RRP7 PF12923.2 EWC45800.1 - 2.5e-23 82.5 10.2 2.5e-23 82.5 7.1 1.7 2 0 0 2 2 2 1 Ribosomal RNA-processing protein 7 (RRP7) TIR PF01582.15 EWC45800.1 - 0.026 13.9 0.1 0.047 13.1 0.1 1.4 1 0 0 1 1 1 0 TIR domain FEZ PF07763.8 EWC45801.1 - 0.026 14.2 0.3 0.055 13.1 0.2 1.5 1 1 0 1 1 1 0 FEZ-like protein Pro_isomerase PF00160.16 EWC45802.1 - 2.3e-34 118.8 0.0 3.8e-34 118.1 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_1 PF00076.17 EWC45802.1 - 8.3e-15 54.1 0.1 1.5e-14 53.3 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EWC45802.1 - 6.6e-11 42.0 0.0 1.3e-10 41.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EWC45802.1 - 2.9e-08 33.4 0.0 5.7e-08 32.4 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MRP-L27 PF09809.4 EWC45804.1 - 2.4e-15 56.1 0.4 3e-15 55.7 0.3 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L27 LisH PF08513.6 EWC45805.1 - 0.068 12.9 0.2 0.11 12.2 0.1 1.4 1 0 0 1 1 1 0 LisH TRAPP PF04051.11 EWC45806.1 - 6.7e-40 136.0 0.0 8.4e-40 135.7 0.0 1.0 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component DUF4250 PF14056.1 EWC45806.1 - 0.06 13.0 0.1 0.13 11.9 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4250) WD40 PF00400.27 EWC45807.1 - 5.4e-50 165.5 7.8 2.3e-09 36.7 0.0 7.5 8 0 0 8 8 8 7 WD domain, G-beta repeat eIF2A PF08662.6 EWC45807.1 - 0.00016 21.4 0.0 1.9 8.1 0.0 3.2 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A X_fast-SP_rel PF06669.6 EWC45807.1 - 0.021 14.7 0.1 0.073 13.0 0.0 1.9 1 0 0 1 1 1 0 Xylella fastidiosa surface protein related Nucleoporin_N PF08801.6 EWC45807.1 - 0.49 9.0 1.8 23 3.5 0.1 3.0 1 1 2 3 3 3 0 Nup133 N terminal like DUF4131 PF13567.1 EWC45808.1 - 0.16 11.3 3.8 0.29 10.5 2.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) DUF2207 PF09972.4 EWC45808.1 - 0.91 8.0 2.1 1.2 7.5 1.4 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Ndc1_Nup PF09531.5 EWC45808.1 - 2.3 6.5 5.9 3.2 6.0 4.1 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PrgI PF12666.2 EWC45808.1 - 9.9 6.3 8.2 18 5.5 5.7 1.3 1 0 0 1 1 1 0 PrgI family protein DUF2205 PF10224.4 EWC45809.1 - 6.8e-29 99.2 1.6 8.5e-29 98.9 1.1 1.1 1 0 0 1 1 1 1 Predicted coiled-coil protein (DUF2205) HOOK PF05622.7 EWC45809.1 - 0.0041 14.9 0.6 0.0049 14.7 0.4 1.0 1 0 0 1 1 1 1 HOOK protein DUF972 PF06156.8 EWC45809.1 - 0.012 15.9 0.8 0.015 15.6 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF972) Pup PF05639.6 EWC45809.1 - 0.067 13.6 1.7 0.11 13.0 1.2 1.5 1 0 0 1 1 1 0 Pup-like protein CASP_C PF08172.7 EWC45809.1 - 0.07 12.1 0.5 0.086 11.8 0.3 1.2 1 0 0 1 1 1 0 CASP C terminal AAA_32 PF13654.1 EWC45809.1 - 0.14 10.8 2.1 0.17 10.5 1.5 1.0 1 0 0 1 1 1 0 AAA domain Membr_traf_MHD PF10540.4 EWC45810.1 - 3.7e-22 78.5 0.1 1.3e-21 76.8 0.0 2.0 2 0 0 2 2 2 1 Munc13 (mammalian uncoordinated) homology domain C2 PF00168.25 EWC45810.1 - 6.7e-16 57.9 0.0 1.5e-15 56.7 0.0 1.7 1 0 0 1 1 1 1 C2 domain DUF810 PF05664.6 EWC45810.1 - 8.1e-06 24.4 0.2 1.5e-05 23.4 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF810) SHS2_Rpb7-N PF03876.12 EWC45811.1 - 2.8e-08 33.7 0.0 1e-07 31.9 0.0 1.9 2 0 0 2 2 2 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 CDC45 PF02724.9 EWC45811.1 - 1.8 6.4 9.8 0.43 8.5 2.8 1.9 2 0 0 2 2 2 0 CDC45-like protein Adeno_VII PF03228.9 EWC45811.1 - 4.7 7.8 9.8 1.9 9.0 1.5 2.2 2 0 0 2 2 2 0 Adenoviral core protein VII UDPGP PF01704.13 EWC45812.1 - 3.7e-54 183.8 0.0 4.7e-54 183.5 0.0 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase NTP_transf_3 PF12804.2 EWC45812.1 - 0.051 13.6 0.0 0.15 12.0 0.0 1.8 2 0 0 2 2 2 0 MobA-like NTP transferase domain HAMP PF00672.20 EWC45813.1 - 9.4e-47 157.0 20.3 8.9e-09 35.4 0.3 7.6 6 2 0 6 6 6 6 HAMP domain HATPase_c PF02518.21 EWC45813.1 - 4.8e-31 106.7 0.1 1.7e-30 105.0 0.1 2.0 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.19 EWC45813.1 - 1.3e-26 92.8 1.1 3.6e-26 91.3 0.1 2.3 2 0 0 2 2 2 1 Response regulator receiver domain HisKA PF00512.20 EWC45813.1 - 1.2e-18 66.8 1.7 9.7e-18 63.9 0.4 3.2 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain DUF4279 PF14106.1 EWC45813.1 - 0.00011 22.0 0.6 8.1 6.3 0.0 5.3 5 0 0 5 5 5 1 Domain of unknown function (DUF4279) AAA_13 PF13166.1 EWC45813.1 - 0.00075 18.0 19.4 0.19 10.1 3.6 4.0 1 1 3 4 4 4 2 AAA domain IL32 PF15225.1 EWC45813.1 - 0.017 15.0 0.0 6.8 6.6 0.0 4.2 3 1 1 4 4 4 0 Interleukin 32 PspB PF06667.7 EWC45813.1 - 0.11 12.4 0.9 70 3.4 0.0 4.3 4 0 0 4 4 4 0 Phage shock protein B WXG100 PF06013.7 EWC45813.1 - 0.22 11.5 18.9 0.96 9.4 0.1 7.0 5 3 0 6 6 6 0 Proteins of 100 residues with WXG Herpes_TK_C PF08465.5 EWC45813.1 - 0.23 10.9 2.3 1.3 8.6 0.1 3.0 3 0 0 3 3 3 0 Thymidine kinase from Herpesvirus C-terminal DUF2365 PF10157.4 EWC45813.1 - 0.99 9.2 24.4 11 5.8 0.2 7.7 5 3 3 9 9 9 0 Uncharacterized conserved protein (DUF2365) FliJ PF02050.11 EWC45813.1 - 2.9 7.9 17.8 0.019 14.9 5.1 2.8 4 0 0 4 4 3 0 Flagellar FliJ protein SNF2_N PF00176.18 EWC45814.1 - 1.1e-75 254.1 0.1 1.7e-75 253.6 0.1 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 EWC45814.1 - 7.9e-14 51.2 0.0 2e-13 50.0 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EWC45814.1 - 2.4e-11 43.8 0.0 5.4e-11 42.6 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF1676 PF07898.8 EWC45814.1 - 1.3 9.3 7.4 19 5.6 2.3 4.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1676) NDUF_B8 PF05821.6 EWC45816.1 - 1.7e-07 31.0 0.0 2.3e-07 30.6 0.0 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) IATP PF04568.7 EWC45817.1 - 2.4e-21 75.6 0.0 2.7e-21 75.4 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial ATPase inhibitor, IATP IncA PF04156.9 EWC45817.1 - 0.0057 16.2 0.2 0.0067 16.0 0.1 1.1 1 0 0 1 1 1 1 IncA protein AAA_23 PF13476.1 EWC45817.1 - 0.009 16.3 0.5 0.01 16.1 0.3 1.1 1 0 0 1 1 1 1 AAA domain FbpA PF05833.6 EWC45817.1 - 0.0093 14.5 0.1 0.0093 14.5 0.1 1.0 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) DivIC PF04977.10 EWC45817.1 - 0.024 14.1 2.1 0.036 13.5 1.5 1.3 1 0 0 1 1 1 0 Septum formation initiator DASH_Dad2 PF08654.5 EWC45817.1 - 0.029 14.3 1.7 0.04 13.9 1.2 1.2 1 0 0 1 1 1 0 DASH complex subunit Dad2 Atg14 PF10186.4 EWC45817.1 - 0.032 13.1 0.1 0.033 13.1 0.0 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 BLOC1_2 PF10046.4 EWC45817.1 - 0.067 13.3 0.6 0.095 12.8 0.4 1.2 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 FlaC_arch PF05377.6 EWC45817.1 - 0.16 11.8 0.3 0.25 11.2 0.2 1.2 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) 14-3-3 PF00244.15 EWC45818.1 - 2.4e-117 390.1 8.4 2.7e-117 389.9 5.8 1.0 1 0 0 1 1 1 1 14-3-3 protein Peptidase_M17_N PF02789.12 EWC45818.1 - 0.016 14.9 0.5 0.22 11.2 0.0 2.4 2 1 0 2 2 2 0 Cytosol aminopeptidase family, N-terminal domain DUF342 PF03961.8 EWC45818.1 - 0.078 11.3 2.4 0.065 11.6 0.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF342) TPR_19 PF14559.1 EWC45818.1 - 0.29 11.4 2.0 2.5 8.5 0.1 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat zf-CCHC PF00098.18 EWC45819.1 - 1.3e-40 135.4 53.6 4.8e-09 35.7 1.5 6.6 7 0 0 7 7 7 6 Zinc knuckle zf-CCHC_4 PF14392.1 EWC45819.1 - 9.8e-10 37.9 36.0 0.016 14.8 0.7 6.1 6 0 0 6 6 6 6 Zinc knuckle zf-CCHC_3 PF13917.1 EWC45819.1 - 2.3e-06 27.2 36.2 0.026 14.2 0.0 6.1 4 2 2 6 6 6 5 Zinc knuckle zf-CCHC_2 PF13696.1 EWC45819.1 - 0.017 14.5 0.8 0.017 14.5 0.6 6.1 5 2 1 6 6 6 0 Zinc knuckle zf-CCHC_6 PF15288.1 EWC45819.1 - 0.053 13.2 37.7 0.19 11.3 1.0 6.0 6 0 0 6 6 6 0 Zinc knuckle Rad51 PF08423.6 EWC45820.1 - 9.6e-121 401.5 0.1 1.3e-120 401.1 0.1 1.1 1 0 0 1 1 1 1 Rad51 RecA PF00154.16 EWC45820.1 - 1.4e-12 47.3 0.1 1.8e-12 46.9 0.1 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein AAA_25 PF13481.1 EWC45820.1 - 3.5e-09 36.3 0.0 5.5e-09 35.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain KaiC PF06745.8 EWC45820.1 - 2e-08 33.6 0.0 4e-08 32.6 0.0 1.6 1 0 0 1 1 1 1 KaiC HHH_5 PF14520.1 EWC45820.1 - 5.1e-05 23.3 0.5 5.1e-05 23.3 0.3 2.4 3 0 0 3 3 3 1 Helix-hairpin-helix domain PAXNEB PF05625.6 EWC45820.1 - 0.033 13.0 0.1 0.051 12.3 0.0 1.2 1 0 0 1 1 1 0 PAXNEB protein DUF296 PF03479.10 EWC45820.1 - 0.08 12.5 0.1 0.26 10.8 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF296) dsrm PF00035.20 EWC45821.1 - 9.2e-08 32.5 0.0 0.028 14.9 0.0 2.9 2 0 0 2 2 2 2 Double-stranded RNA binding motif DND1_DSRM PF14709.1 EWC45821.1 - 4.4e-05 23.6 0.2 0.021 15.0 0.0 2.7 3 0 0 3 3 3 2 double strand RNA binding domain from DEAD END PROTEIN 1 MTBP_C PF14920.1 EWC45823.1 - 0.091 12.2 5.0 0.13 11.6 3.4 1.2 1 0 0 1 1 1 0 MDM2-binding RRM_1 PF00076.17 EWC45824.1 - 2.7e-45 151.8 0.0 9.6e-17 60.3 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EWC45824.1 - 2.8e-25 88.0 0.0 2.4e-09 37.0 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EWC45824.1 - 1.6e-21 75.9 0.0 3.1e-08 33.3 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 EWC45824.1 - 6.8e-07 29.0 0.0 0.00012 21.8 0.0 2.7 3 0 0 3 3 3 1 RNA binding motif Nup35_RRM_2 PF14605.1 EWC45824.1 - 0.0002 21.0 0.0 0.01 15.5 0.0 2.7 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif Tcp11 PF05794.8 EWC45825.1 - 3.5e-80 269.8 0.0 4.2e-80 269.6 0.0 1.0 1 0 0 1 1 1 1 T-complex protein 11 DENN PF02141.16 EWC45826.1 - 4.8e-43 147.0 1.2 7.9e-43 146.3 0.9 1.3 1 0 0 1 1 1 1 DENN (AEX-3) domain PP2C PF00481.16 EWC45827.1 - 2.9e-80 269.3 0.0 3.8e-80 268.9 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.1 EWC45827.1 - 0.018 14.4 0.0 0.051 12.9 0.0 1.7 1 1 0 1 1 1 0 Protein phosphatase 2C WD40 PF00400.27 EWC45829.1 - 1.7e-26 91.0 4.5 2e-06 27.4 0.1 6.0 6 0 0 6 6 6 4 WD domain, G-beta repeat Peptidase_S10 PF00450.17 EWC45830.1 - 1.1e-111 373.9 0.0 1.4e-111 373.5 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Med18 PF09637.5 EWC45831.1 - 3.7e-47 160.9 0.0 7.3e-47 160.0 0.0 1.4 1 1 0 1 1 1 1 Med18 protein Endosulfine PF04667.12 EWC45832.1 - 8.6e-24 83.3 0.4 1.5e-23 82.5 0.0 1.6 2 0 0 2 2 2 1 cAMP-regulated phosphoprotein/endosulfine conserved region G-patch PF01585.18 EWC45833.1 - 3.6e-10 39.4 2.3 7.3e-10 38.4 1.6 1.6 1 0 0 1 1 1 1 G-patch domain RRM_5 PF13893.1 EWC45833.1 - 4.4e-08 32.8 0.1 1.5e-07 31.1 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 EWC45833.1 - 1.6e-07 30.8 0.0 7.3e-07 28.7 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EWC45833.1 - 0.00013 21.8 0.0 0.00025 20.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) UCR_14kD PF02271.11 EWC45834.1 - 5e-42 141.9 0.3 5.8e-42 141.7 0.2 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex 14kD subunit She9_MDM33 PF05546.6 EWC45834.1 - 0.1 12.1 0.0 0.11 12.0 0.0 1.1 1 0 0 1 1 1 0 She9 / Mdm33 family Recep_L_domain PF01030.19 EWC45835.1 - 2.2e-09 37.2 0.0 0.0034 17.3 0.0 4.5 1 1 2 4 4 4 4 Receptor L domain Ecm33 PF12454.3 EWC45835.1 - 5.8e-06 26.0 0.8 5.8e-06 26.0 0.6 2.0 2 0 0 2 2 2 1 GPI-anchored cell wall organization protein LRR_5 PF13306.1 EWC45835.1 - 0.0042 16.7 0.1 0.57 9.8 0.0 2.4 2 0 0 2 2 2 2 Leucine rich repeats (6 copies) Ins_P5_2-kin PF06090.7 EWC45836.1 - 2.2e-44 151.7 0.0 2.7e-44 151.5 0.0 1.1 1 0 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase FAA_hydrolase PF01557.13 EWC45837.1 - 1e-48 165.7 0.0 1.2e-48 165.4 0.0 1.0 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Aconitase PF00330.15 EWC45838.1 - 4.8e-142 473.7 0.0 1e-128 429.7 0.0 2.8 1 1 1 2 2 2 2 Aconitase family (aconitate hydratase) Aconitase_C PF00694.14 EWC45838.1 - 2.1e-39 134.6 0.0 4e-38 130.4 0.0 2.4 2 0 0 2 2 2 1 Aconitase C-terminal domain bZIP_2 PF07716.10 EWC45839.1 - 7.2e-13 48.1 8.1 1.2e-12 47.3 5.6 1.3 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.16 EWC45839.1 - 1.5e-06 28.0 9.9 3.7e-06 26.7 6.8 1.7 1 1 0 1 1 1 1 bZIP transcription factor FlgN PF05130.7 EWC45839.1 - 0.0015 18.7 1.9 0.0021 18.3 1.3 1.2 1 0 0 1 1 1 1 FlgN protein XhlA PF10779.4 EWC45839.1 - 0.016 15.0 2.6 0.029 14.2 1.8 1.4 1 0 0 1 1 1 0 Haemolysin XhlA TFIIA PF03153.8 EWC45839.1 - 0.018 14.9 9.2 0.023 14.5 6.4 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit TSC22 PF01166.13 EWC45839.1 - 0.054 13.4 1.7 0.083 12.8 0.3 1.9 1 1 1 2 2 2 0 TSC-22/dip/bun family DUF496 PF04363.7 EWC45839.1 - 0.063 13.1 0.8 0.12 12.1 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF496) DUF2884 PF11101.3 EWC45839.1 - 0.068 12.5 0.9 0.086 12.2 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2884) IncA PF04156.9 EWC45839.1 - 0.094 12.3 3.8 0.11 12.0 2.6 1.4 1 1 0 1 1 1 0 IncA protein bZIP_Maf PF03131.12 EWC45839.1 - 0.14 12.4 7.0 0.22 11.8 4.6 1.5 1 1 0 1 1 1 0 bZIP Maf transcription factor DUF972 PF06156.8 EWC45839.1 - 0.86 9.9 3.9 1.1 9.6 0.9 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Ndc1_Nup PF09531.5 EWC45839.1 - 5.9 5.1 8.2 6.7 5.0 5.7 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup MHYT PF03707.11 EWC45841.1 - 6.5e-08 32.5 13.0 2.7e-05 24.1 1.2 4.5 5 0 0 5 5 5 2 Bacterial signalling protein N terminal repeat DUF2638 PF10937.3 EWC45842.1 - 1.6e-23 83.8 1.0 6.2e-23 81.9 0.7 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF2638) Annexin PF00191.15 EWC45843.1 - 2.8e-31 107.2 0.0 1.6e-06 27.8 0.0 4.2 4 0 0 4 4 4 4 Annexin Anp1 PF03452.9 EWC45844.1 - 1.2e-107 359.1 0.0 1.4e-107 358.8 0.0 1.1 1 0 0 1 1 1 1 Anp1 PP2C PF00481.16 EWC45845.1 - 5.7e-41 140.6 0.0 1.1e-40 139.7 0.0 1.4 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.1 EWC45845.1 - 0.00034 20.0 0.0 0.00072 19.0 0.0 1.5 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.7 EWC45845.1 - 0.03 14.0 0.0 5.6 6.6 0.0 2.6 3 0 0 3 3 3 0 Stage II sporulation protein E (SpoIIE) PNK3P PF08645.6 EWC45846.1 - 2.3e-56 189.6 0.0 3.3e-56 189.1 0.0 1.2 1 0 0 1 1 1 1 Polynucleotide kinase 3 phosphatase AAA_33 PF13671.1 EWC45846.1 - 9e-21 74.2 0.0 1.2e-19 70.6 0.0 2.5 2 1 0 2 2 2 1 AAA domain KTI12 PF08433.5 EWC45846.1 - 0.0025 17.0 0.2 0.41 9.7 0.0 2.3 1 1 1 2 2 2 2 Chromatin associated protein KTI12 AAA_22 PF13401.1 EWC45846.1 - 0.0087 16.2 0.0 0.017 15.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 EWC45846.1 - 0.0091 15.1 0.0 0.041 12.9 0.0 1.8 1 1 0 2 2 2 1 Zeta toxin AAA_17 PF13207.1 EWC45846.1 - 0.016 15.9 0.1 0.063 14.1 0.0 2.1 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.1 EWC45846.1 - 0.05 13.9 0.7 4.7 7.5 0.1 2.6 2 1 1 3 3 3 0 AAA domain Zot PF05707.7 EWC45846.1 - 0.067 12.6 0.0 1 8.7 0.0 2.2 2 0 0 2 2 2 0 Zonular occludens toxin (Zot) APS_kinase PF01583.15 EWC45846.1 - 0.1 12.2 0.0 16 5.0 0.0 2.4 1 1 1 2 2 2 0 Adenylylsulphate kinase RNR_inhib PF08591.5 EWC45846.1 - 0.13 13.1 0.0 0.45 11.4 0.0 1.9 2 0 0 2 2 1 0 Ribonucleotide reductase inhibitor AAA_29 PF13555.1 EWC45846.1 - 0.14 11.7 0.0 0.82 9.2 0.0 2.1 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_25 PF13481.1 EWC45846.1 - 0.15 11.4 0.0 0.42 9.9 0.0 1.7 2 0 0 2 2 2 0 AAA domain KaiC PF06745.8 EWC45846.1 - 0.16 11.0 0.1 0.29 10.2 0.0 1.5 1 1 0 1 1 1 0 KaiC Methyltransf_16 PF10294.4 EWC45848.1 - 1.8e-47 161.0 0.0 2.2e-47 160.7 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_18 PF12847.2 EWC45848.1 - 0.027 15.0 0.0 0.04 14.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.1 EWC45848.1 - 0.064 12.8 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain AAA_18 PF13238.1 EWC45850.1 - 2.1e-10 40.9 0.0 3.7e-10 40.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 EWC45850.1 - 6.1e-05 23.8 0.0 0.0001 23.1 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 EWC45850.1 - 0.001 19.0 0.1 0.0022 18.0 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.1 EWC45850.1 - 0.0018 18.1 0.0 0.003 17.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.16 EWC45850.1 - 0.028 13.5 0.0 0.049 12.7 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI APS_kinase PF01583.15 EWC45850.1 - 0.061 12.9 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase KTI12 PF08433.5 EWC45850.1 - 0.08 12.1 0.0 0.12 11.5 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 CPT PF07931.7 EWC45850.1 - 0.13 11.8 0.0 0.87 9.1 0.0 2.2 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein DUF3984 PF13136.1 EWC45850.1 - 6.9 5.7 7.3 2.5 7.2 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3984) Nnf1 PF03980.9 EWC45851.1 - 0.09 12.7 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 Nnf1 DnaJ PF00226.26 EWC45852.1 - 7.5e-25 86.4 0.5 1.3e-24 85.6 0.3 1.4 1 0 0 1 1 1 1 DnaJ domain DUF1977 PF09320.6 EWC45852.1 - 2.4e-19 69.5 0.2 4.1e-19 68.8 0.0 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF1977) Y_phosphatase2 PF03162.8 EWC45853.1 - 7.5e-57 191.2 0.0 1.1e-56 190.7 0.0 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.1 EWC45853.1 - 2.3e-07 31.1 0.0 6e-07 29.8 0.0 1.6 1 1 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.15 EWC45853.1 - 1.5e-05 24.6 0.0 2.2e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 EWC45853.1 - 0.0014 18.0 0.0 0.0019 17.6 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase HhH-GPD PF00730.20 EWC45855.1 - 3.2e-15 56.3 0.0 8.7e-15 54.9 0.0 1.7 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HMG14_17 PF01101.13 EWC45855.1 - 0.58 10.8 11.0 1.4 9.6 7.6 1.6 1 0 0 1 1 1 0 HMG14 and HMG17 Ima1_N PF09779.4 EWC45857.1 - 8e-21 74.9 3.8 8.9e-21 74.7 2.6 1.0 1 0 0 1 1 1 1 Ima1 N-terminal domain zf-CHY PF05495.7 EWC45857.1 - 0.034 14.3 2.7 0.71 10.0 0.3 2.2 2 0 0 2 2 2 0 CHY zinc finger zf-Sec23_Sec24 PF04810.10 EWC45857.1 - 0.037 13.5 0.2 0.037 13.5 0.1 3.1 3 0 0 3 3 3 0 Sec23/Sec24 zinc finger Elf1 PF05129.8 EWC45857.1 - 0.056 13.1 7.0 2.5 7.8 0.7 2.8 2 1 1 3 3 3 0 Transcription elongation factor Elf1 like HypA PF01155.14 EWC45857.1 - 0.15 11.7 4.0 4.8 6.9 0.5 2.2 2 0 0 2 2 2 0 Hydrogenase expression/synthesis hypA family zf-H2C2_2 PF13465.1 EWC45857.1 - 0.32 11.3 9.1 1.5 9.2 0.0 3.3 3 0 0 3 3 3 0 Zinc-finger double domain BIR PF00653.16 EWC45857.1 - 0.42 11.0 3.1 0.74 10.2 0.7 2.4 2 1 0 2 2 2 0 Inhibitor of Apoptosis domain GCC2_GCC3 PF07699.8 EWC45857.1 - 0.78 9.3 10.4 0.49 10.0 3.0 2.6 2 0 0 2 2 2 0 GCC2 and GCC3 Lar_restr_allev PF14354.1 EWC45857.1 - 1.1 9.6 5.5 0.35 11.1 0.9 2.1 1 1 1 2 2 2 0 Restriction alleviation protein Lar RNHCP PF12647.2 EWC45857.1 - 1.9 8.3 5.4 4 7.3 3.8 1.7 1 1 0 1 1 1 0 RNHCP domain ICE2 PF08426.5 EWC45858.1 - 2.5e-116 388.7 3.5 3e-116 388.4 2.4 1.0 1 0 0 1 1 1 1 ICE2 YCII PF03795.9 EWC45860.1 - 1.8e-07 31.2 0.0 2.3e-07 30.9 0.0 1.1 1 0 0 1 1 1 1 YCII-related domain Vfa1 PF08432.5 EWC45861.1 - 3.3e-44 151.0 12.7 4.2e-44 150.7 8.8 1.1 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 DUF2072 PF09845.4 EWC45861.1 - 0.071 13.0 6.3 0.14 12.0 4.4 1.5 1 0 0 1 1 1 0 Zn-ribbon containing protein (DUF2072) zf-C3HC4_3 PF13920.1 EWC45861.1 - 0.075 12.7 0.5 0.13 11.9 0.3 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) RR_TM4-6 PF06459.7 EWC45861.1 - 0.12 12.2 10.5 0.15 11.9 7.3 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 NPR3 PF03666.8 EWC45861.1 - 0.13 10.8 5.6 0.16 10.4 3.9 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Atg14 PF10186.4 EWC45861.1 - 0.17 10.7 3.7 0.19 10.6 2.5 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Herpes_UL25 PF01499.11 EWC45861.1 - 0.23 9.7 2.5 0.28 9.4 1.7 1.1 1 0 0 1 1 1 0 Herpesvirus UL25 family Neur_chan_memb PF02932.11 EWC45861.1 - 0.81 9.5 3.1 0.93 9.3 2.1 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Ycf1 PF05758.7 EWC45861.1 - 1.1 6.9 9.5 1.2 6.7 6.6 1.0 1 0 0 1 1 1 0 Ycf1 DUF2856 PF11043.3 EWC45861.1 - 1.5 8.9 5.3 2.7 8.1 3.7 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2856) DUF262 PF03235.9 EWC45861.1 - 1.7 8.5 5.3 2 8.3 3.7 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF262 U79_P34 PF03064.11 EWC45861.1 - 1.8 7.9 13.0 0.099 12.1 5.7 1.5 2 0 0 2 2 2 0 HSV U79 / HCMV P34 RAP1 PF07218.6 EWC45861.1 - 3.2 5.7 12.0 3.9 5.4 8.3 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Rtf2 PF04641.7 EWC45861.1 - 5.5 6.1 18.3 8.5 5.4 12.7 1.5 1 1 0 1 1 1 0 Rtf2 RING-finger APG6 PF04111.7 EWC45861.1 - 5.6 5.9 16.2 7.3 5.5 11.2 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 Sec62 PF03839.11 EWC45861.1 - 7.4 5.9 10.8 9.1 5.6 7.5 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 DUF4407 PF14362.1 EWC45861.1 - 9.5 5.0 9.4 12 4.7 6.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TatD_DNase PF01026.16 EWC45863.1 - 1.4e-49 168.6 0.0 1.7e-49 168.3 0.0 1.1 1 0 0 1 1 1 1 TatD related DNase Alg14 PF08660.6 EWC45864.1 - 5.2e-29 101.4 0.0 8.3e-29 100.7 0.0 1.3 1 0 0 1 1 1 1 Oligosaccharide biosynthesis protein Alg14 like Pex26 PF07163.7 EWC45864.1 - 0.12 11.2 0.0 0.15 10.8 0.0 1.2 1 0 0 1 1 1 0 Pex26 protein KOW PF00467.24 EWC45865.1 - 0.0063 16.1 3.9 0.016 14.8 2.7 1.7 1 0 0 1 1 1 1 KOW motif Lactamase_B PF00753.22 EWC45866.1 - 1.9e-25 89.6 0.3 2.9e-25 89.0 0.2 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 EWC45866.1 - 1.6e-06 27.8 0.1 2.1e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.1 EWC45866.1 - 0.023 14.4 0.1 0.038 13.7 0.0 1.4 1 0 0 1 1 1 0 Beta-lactamase superfamily domain CENP-N PF05238.8 EWC45867.1 - 4.2e-73 246.7 0.0 6.5e-73 246.0 0.0 1.3 1 1 0 1 1 1 1 Kinetochore protein CHL4 like zf-P11 PF03854.9 EWC45867.1 - 0.088 12.2 0.3 1.1 8.7 0.0 2.2 2 0 0 2 2 2 0 P-11 zinc finger AMP-binding PF00501.23 EWC45868.1 - 6.9e-90 301.4 0.0 8.5e-90 301.1 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 EWC45868.1 - 2.8e-15 57.0 0.2 7.2e-15 55.7 0.1 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain GH3 PF03321.8 EWC45868.1 - 0.00027 19.5 0.0 0.0069 14.9 0.0 2.2 2 0 0 2 2 2 1 GH3 auxin-responsive promoter PEPcase_2 PF14010.1 EWC45868.1 - 0.015 13.5 0.1 0.021 13.1 0.1 1.1 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxylase DUF647 PF04884.9 EWC45869.1 - 4.5e-96 320.8 2.6 5.9e-96 320.4 1.8 1.1 1 0 0 1 1 1 1 Vitamin B6 photo-protection and homoeostasis DUF2227 PF09988.4 EWC45869.1 - 0.014 15.0 0.2 1.5 8.4 0.0 2.3 1 1 1 2 2 2 0 Uncharacterized metal-binding protein (DUF2227) MobB PF03205.9 EWC45869.1 - 0.097 12.3 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Phage_tail_U PF06141.6 EWC45869.1 - 0.12 12.3 0.0 0.42 10.6 0.0 1.8 2 0 0 2 2 2 0 Phage minor tail protein U RGS PF00615.14 EWC45870.1 - 1.2e-11 44.7 0.0 1.9e-11 44.1 0.0 1.2 1 0 0 1 1 1 1 Regulator of G protein signaling domain BBS2_C PF14782.1 EWC45871.1 - 0.016 13.8 0.3 0.019 13.5 0.2 1.2 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, C-terminal Rifin_STEVOR PF02009.11 EWC45871.1 - 0.11 12.1 0.9 0.14 11.8 0.6 1.1 1 0 0 1 1 1 0 Rifin/stevor family IFRD_C PF04836.7 EWC45871.1 - 2.9 8.1 6.8 9.3 6.5 4.7 1.9 1 1 0 1 1 1 0 Interferon-related protein conserved region Viral_P18 PF04521.8 EWC45871.1 - 6.4 6.2 6.1 3.2 7.2 0.1 2.2 1 1 1 2 2 2 0 ssRNA positive strand viral 18kD cysteine rich protein Tcp11 PF05794.8 EWC45872.1 - 1.3e-64 218.6 4.8 2.7e-64 217.5 0.1 2.4 2 0 0 2 2 2 2 T-complex protein 11 DUF2216 PF10226.4 EWC45873.1 - 0.11 12.0 0.4 0.2 11.1 0.0 1.5 2 0 0 2 2 2 0 Uncharacterized conserved proteins (DUF2216) Aldo_ket_red PF00248.16 EWC45874.1 - 2.4e-42 144.7 0.0 2.9e-42 144.4 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family RhoGAP PF00620.22 EWC45875.1 - 5.2e-28 97.5 0.1 8.8e-28 96.8 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain CRAL_TRIO_2 PF13716.1 EWC45875.1 - 3.1e-14 53.1 0.0 5.5e-14 52.3 0.0 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.15 EWC45875.1 - 0.038 13.4 0.0 0.12 11.8 0.0 1.8 2 0 0 2 2 2 0 CRAL/TRIO domain ETS_PEA3_N PF04621.8 EWC45875.1 - 4.8 6.3 7.5 7.1 5.7 5.2 1.3 1 0 0 1 1 1 0 PEA3 subfamily ETS-domain transcription factor N terminal domain CRAL_TRIO_2 PF13716.1 EWC45876.1 - 0.0011 18.8 0.0 0.0014 18.4 0.0 1.1 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain HMA PF00403.21 EWC45877.1 - 1.5e-05 25.0 0.1 2.8e-05 24.1 0.1 1.5 1 1 0 1 1 1 1 Heavy-metal-associated domain Steroid_dh PF02544.11 EWC45879.1 - 2.5e-20 72.7 2.3 2.6e-15 56.4 0.0 2.5 3 0 0 3 3 3 2 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.7 EWC45879.1 - 0.00057 19.2 1.1 0.00057 19.2 0.8 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1295) DUF2637 PF10935.3 EWC45879.1 - 0.0054 16.6 0.2 0.01 15.8 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2637) zf-H2C2_2 PF13465.1 EWC45880.1 - 1.6e-13 50.1 8.7 4.7e-08 32.9 0.2 3.8 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2 PF00096.21 EWC45880.1 - 1.7e-11 43.7 12.4 7.2e-06 26.0 1.6 3.8 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EWC45880.1 - 8.4e-11 41.4 12.4 3.5e-05 23.8 1.8 3.8 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 EWC45880.1 - 2.8e-07 30.4 2.8 0.027 14.6 0.1 3.7 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 EWC45880.1 - 4.1e-05 23.6 1.9 0.012 15.7 0.2 3.1 3 0 0 3 3 3 1 Zinc-finger of C2H2 type Zn_ribbon_recom PF13408.1 EWC45880.1 - 0.011 16.0 0.5 0.023 14.9 0.3 1.5 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain zf-Di19 PF05605.7 EWC45880.1 - 0.07 13.2 1.7 0.19 11.9 1.2 1.7 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding LIM PF00412.17 EWC45880.1 - 0.87 9.7 2.7 6.9 6.8 1.9 2.2 1 1 1 2 2 2 0 LIM domain zf-C2H2_6 PF13912.1 EWC45880.1 - 0.99 9.3 8.1 9.8 6.2 0.4 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger Ribosomal_S10 PF00338.17 EWC45881.1 - 6.6e-09 35.5 0.1 7.7e-09 35.2 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e Senescence PF06911.7 EWC45882.1 - 0.0018 17.9 1.5 0.0019 17.9 1.1 1.1 1 0 0 1 1 1 1 Senescence-associated protein Kelch_3 PF13415.1 EWC45883.1 - 2.4e-08 33.8 6.6 0.13 12.4 0.1 5.7 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_4 PF13418.1 EWC45883.1 - 5.9e-07 29.1 6.8 0.028 14.1 0.1 5.0 4 1 0 4 4 4 3 Galactose oxidase, central domain Kelch_5 PF13854.1 EWC45883.1 - 1.7e-05 24.6 0.1 0.014 15.3 0.0 4.1 4 0 0 4 4 4 1 Kelch motif Kelch_6 PF13964.1 EWC45883.1 - 0.00091 19.3 3.0 21 5.5 0.0 4.8 5 0 0 5 5 5 0 Kelch motif DUF3357 PF11837.3 EWC45883.1 - 0.049 13.4 3.0 0.066 13.0 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3357) Adeno_E3_CR2 PF02439.10 EWC45883.1 - 0.14 11.7 1.2 0.26 10.8 0.9 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 EphA2_TM PF14575.1 EWC45883.1 - 0.49 10.8 5.2 0.66 10.4 0.0 2.6 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain BAF1_ABF1 PF04684.8 EWC45883.1 - 0.69 8.6 36.4 1.1 8.0 25.2 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor YajC PF02699.10 EWC45883.1 - 1.4 8.6 0.0 1.4 8.6 0.0 2.8 3 1 1 4 4 4 0 Preprotein translocase subunit Pkinase PF00069.20 EWC45884.1 - 4.8e-53 179.9 0.2 8.4e-37 126.7 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 EWC45884.1 - 1.2e-25 90.0 0.0 2.5e-24 85.7 0.0 2.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EWC45884.1 - 8.9e-07 28.1 0.0 1.8e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 EWC45884.1 - 0.025 14.2 1.1 0.1 12.3 0.8 2.0 1 1 0 1 1 1 0 Phosphotransferase enzyme family Reo_sigmaC PF04582.7 EWC45885.1 - 0.0031 16.7 1.1 0.0044 16.2 0.8 1.2 1 0 0 1 1 1 1 Reovirus sigma C capsid protein SlyX PF04102.7 EWC45885.1 - 0.027 14.8 1.9 0.027 14.8 1.3 2.7 2 0 0 2 2 2 0 SlyX DUF1839 PF08893.5 EWC45885.1 - 0.097 11.6 0.1 0.14 11.0 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1839) NPV_P10 PF05531.7 EWC45885.1 - 0.12 12.6 3.8 2.6 8.3 1.1 2.7 1 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Cluap1 PF10234.4 EWC45885.1 - 0.12 11.5 4.0 0.19 10.8 2.8 1.2 1 0 0 1 1 1 0 Clusterin-associated protein-1 IL6 PF00489.12 EWC45885.1 - 0.16 11.5 1.9 0.17 11.5 0.2 1.8 2 0 0 2 2 2 0 Interleukin-6/G-CSF/MGF family FlaC_arch PF05377.6 EWC45885.1 - 0.23 11.3 5.9 4.8 7.1 0.6 2.6 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Mnd1 PF03962.10 EWC45885.1 - 0.3 10.7 5.4 0.32 10.6 3.0 1.6 1 1 0 1 1 1 0 Mnd1 family Spc7 PF08317.6 EWC45885.1 - 0.4 9.2 9.6 0.62 8.6 6.7 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein UPF0242 PF06785.6 EWC45885.1 - 0.81 8.3 6.0 1.2 7.7 4.2 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) Snapin_Pallidin PF14712.1 EWC45885.1 - 0.99 9.7 8.1 3.5 7.9 0.8 2.3 2 0 0 2 2 2 0 Snapin/Pallidin DUF972 PF06156.8 EWC45885.1 - 1.4 9.2 8.4 1 9.7 1.9 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF972) TMF_DNA_bd PF12329.3 EWC45885.1 - 2.4 8.0 15.4 5.2 6.9 2.8 2.5 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF2570 PF10828.3 EWC45885.1 - 3 7.4 7.1 0.28 10.7 0.4 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2570) Chorismate_synt PF01264.16 EWC45886.1 - 1e-130 435.2 0.0 1.2e-130 435.0 0.0 1.0 1 0 0 1 1 1 1 Chorismate synthase BPL_LplA_LipB PF03099.14 EWC45887.1 - 1.6e-18 66.9 0.0 2.7e-18 66.1 0.0 1.3 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family tRNA-synt_1g PF09334.6 EWC45888.1 - 2.1e-144 480.9 0.0 2.8e-144 480.5 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.17 EWC45888.1 - 1.2e-08 33.4 1.3 0.002 16.1 0.0 3.8 2 2 1 3 3 3 3 tRNA synthetases class I (I, L, M and V) MetRS-N PF09635.5 EWC45888.1 - 0.0025 18.1 0.0 0.017 15.4 0.0 2.2 1 1 0 1 1 1 1 MetRS-N binding domain Yae1_N PF09811.4 EWC45889.1 - 1.6e-07 30.7 4.5 1.6e-07 30.7 3.1 1.9 2 0 0 2 2 2 1 Essential protein Yae1, N terminal BBIP10 PF14777.1 EWC45890.1 - 0.039 13.3 0.2 0.075 12.4 0.2 1.4 1 0 0 1 1 1 0 Cilia BBSome complex subunit 10 Meth_synt_2 PF01717.13 EWC45891.1 - 1.2e-144 481.2 0.0 7.2e-139 462.2 0.0 2.6 3 0 0 3 3 3 2 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.7 EWC45891.1 - 4e-127 423.7 0.0 8.8e-114 379.9 0.0 3.1 3 0 0 3 3 3 3 Cobalamin-independent synthase, N-terminal domain URO-D PF01208.12 EWC45891.1 - 0.041 12.7 0.0 6 5.6 0.0 2.8 2 0 0 2 2 2 0 Uroporphyrinogen decarboxylase (URO-D) RasGEF PF00617.14 EWC45892.1 - 5.3e-54 182.8 0.0 9.9e-54 181.9 0.0 1.4 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.15 EWC45892.1 - 2.1e-12 47.0 0.0 7e-12 45.3 0.0 1.9 2 0 0 2 2 2 1 RasGEF N-terminal motif SH3_1 PF00018.23 EWC45892.1 - 0.0002 20.6 0.0 0.00041 19.6 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 EWC45892.1 - 0.00036 20.0 0.0 0.00092 18.7 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain Propep_M14 PF02244.11 EWC45893.1 - 0.022 14.3 0.3 0.089 12.4 0.1 2.1 2 0 0 2 2 2 0 Carboxypeptidase activation peptide GAS PF13851.1 EWC45893.1 - 4.2 6.5 30.5 0.69 9.0 6.8 3.1 3 0 0 3 3 3 0 Growth-arrest specific micro-tubule binding 3HCDH_N PF02737.13 EWC45894.1 - 5.7e-39 133.6 1.9 7.5e-39 133.2 1.3 1.1 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.17 EWC45894.1 - 7.9e-35 119.1 0.0 1.4e-34 118.3 0.0 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain NAD_binding_2 PF03446.10 EWC45894.1 - 0.054 13.3 0.2 0.11 12.3 0.1 1.5 1 1 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Med5 PF08689.5 EWC45896.1 - 9.2e-109 364.6 0.0 1.1e-108 364.3 0.0 1.0 1 0 0 1 1 1 1 Mediator complex subunit Med5 ELFV_dehydrog PF00208.16 EWC45899.1 - 6.2e-79 265.0 1.5 7.6e-79 264.7 1.1 1.1 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.13 EWC45899.1 - 2e-49 166.5 0.0 3.5e-49 165.7 0.0 1.4 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain Thiolase_C PF02803.13 EWC45900.1 - 1.1e-09 37.8 1.4 8.4e-09 34.9 0.0 2.5 1 1 1 2 2 2 1 Thiolase, C-terminal domain ACP_syn_III PF08545.5 EWC45900.1 - 3.9e-06 26.4 0.0 0.0012 18.4 0.0 2.7 2 0 0 2 2 2 2 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Thiolase_N PF00108.18 EWC45900.1 - 0.00077 18.5 0.1 0.0052 15.7 0.0 2.1 2 0 0 2 2 2 1 Thiolase, N-terminal domain zf-CCHC_4 PF14392.1 EWC45901.1 - 0.08 12.6 0.8 0.16 11.6 0.5 1.5 1 0 0 1 1 1 0 Zinc knuckle DUF4404 PF14357.1 EWC45901.1 - 0.19 12.1 1.1 0.4 11.1 0.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4404) 60KD_IMP PF02096.15 EWC45902.1 - 1.5e-20 73.7 0.0 2.7e-20 72.8 0.0 1.4 1 1 0 1 1 1 1 60Kd inner membrane protein Glycos_transf_1 PF00534.15 EWC45903.1 - 2.1e-23 82.6 0.0 3.8e-23 81.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.1 EWC45903.1 - 4.6e-09 36.5 0.0 1.3e-08 35.0 0.0 1.8 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.1 EWC45903.1 - 0.00079 19.6 0.9 0.0019 18.3 0.6 1.7 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_transf_4 PF13439.1 EWC45903.1 - 0.011 15.4 0.2 0.057 13.1 0.0 2.2 3 0 0 3 3 3 0 Glycosyltransferase Family 4 Tcf25 PF04910.9 EWC45904.1 - 5.2e-68 229.6 0.0 7.9e-68 229.0 0.0 1.3 1 0 0 1 1 1 1 Transcriptional repressor TCF25 CAP_N PF01213.14 EWC45904.1 - 0.034 13.4 0.2 0.034 13.4 0.1 2.2 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal TPR_19 PF14559.1 EWC45904.1 - 0.035 14.4 1.6 0.36 11.1 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat SURF2 PF05477.6 EWC45904.1 - 0.036 13.1 12.7 0.057 12.5 8.8 1.2 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) Dicty_REP PF05086.7 EWC45904.1 - 2 6.1 6.0 2.7 5.6 4.2 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein HSP90 PF00183.13 EWC45904.1 - 8.8 4.5 9.0 17 3.6 6.3 1.4 1 0 0 1 1 1 0 Hsp90 protein S1-P1_nuclease PF02265.11 EWC45905.1 - 6.3e-70 235.6 0.0 1.2e-69 234.8 0.0 1.5 1 0 0 1 1 1 1 S1/P1 Nuclease Xpo1 PF08389.7 EWC45906.1 - 2e-08 34.2 0.3 1.3e-06 28.3 0.2 3.3 1 1 0 1 1 1 1 Exportin 1-like protein IBN_N PF03810.14 EWC45906.1 - 0.039 13.8 0.0 0.86 9.5 0.0 3.3 3 1 1 4 4 4 0 Importin-beta N-terminal domain HATPase_c PF02518.21 EWC45907.1 - 2e-26 91.9 0.0 5.8e-26 90.3 0.0 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.19 EWC45907.1 - 1.1e-23 83.4 0.0 2.2e-23 82.3 0.0 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.20 EWC45907.1 - 2.5e-19 69.0 0.4 6.9e-19 67.6 0.3 1.8 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_3 PF08447.6 EWC45907.1 - 1.9e-16 59.8 0.0 1.9e-15 56.6 0.0 2.5 2 0 0 2 2 2 1 PAS fold PAS_9 PF13426.1 EWC45907.1 - 1.9e-12 47.4 0.0 3.5e-05 24.1 0.0 3.5 3 1 0 3 3 3 2 PAS domain PAS_4 PF08448.5 EWC45907.1 - 3.6e-06 26.9 0.0 0.0017 18.3 0.0 4.2 3 1 0 3 3 3 1 PAS fold PAS PF00989.19 EWC45907.1 - 1.6e-05 24.6 0.0 0.0065 16.2 0.0 3.2 3 0 0 3 3 3 1 PAS fold HATPase_c_3 PF13589.1 EWC45907.1 - 0.08 12.5 0.0 0.2 11.3 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Mito_carr PF00153.22 EWC45908.1 - 2e-74 245.3 2.3 7.7e-26 89.6 0.2 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein Redoxin PF08534.5 EWC45909.1 - 8.6e-29 99.9 0.4 1e-28 99.7 0.3 1.1 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.16 EWC45909.1 - 2.7e-10 39.9 0.0 3.5e-10 39.6 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Ribonuc_red_lgC PF02867.10 EWC45910.1 - 1.1e-215 717.3 0.0 1.5e-215 716.8 0.0 1.2 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.16 EWC45910.1 - 1.1e-25 89.1 0.1 3.7e-25 87.5 0.0 1.9 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.11 EWC45910.1 - 1.5e-16 60.5 1.3 3.7e-16 59.3 0.1 2.3 2 0 0 2 2 2 1 ATP cone domain HEM4 PF02602.10 EWC45911.1 - 2.1e-31 108.9 0.0 2.6e-31 108.6 0.0 1.1 1 0 0 1 1 1 1 Uroporphyrinogen-III synthase HemD Myb_DNA-binding PF00249.26 EWC45912.1 - 5.1e-14 52.0 1.0 1e-10 41.4 0.1 3.8 3 1 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 EWC45912.1 - 2.1e-11 43.7 6.9 3.4e-11 43.0 0.3 3.3 4 0 0 4 4 4 1 Myb-like DNA-binding domain Raffinose_syn PF05691.7 EWC45913.1 - 2e-50 171.1 7.3 4.5e-41 140.2 5.9 4.0 2 1 0 2 2 2 2 Raffinose synthase or seed imbibition protein Sip1 Melibiase PF02065.13 EWC45913.1 - 3.1e-05 22.8 0.7 4.7e-05 22.2 0.5 1.3 1 0 0 1 1 1 1 Melibiase GDPD PF03009.12 EWC45914.1 - 6.3e-11 42.2 0.0 9.5e-11 41.6 0.0 1.3 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Glyco_transf_20 PF00982.16 EWC45915.1 - 4.3e-152 506.8 0.0 9.1e-152 505.8 0.0 1.4 2 0 0 2 2 2 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.11 EWC45915.1 - 4.5e-88 294.1 0.0 7e-88 293.5 0.0 1.3 1 0 0 1 1 1 1 Trehalose-phosphatase Hydrolase_3 PF08282.7 EWC45915.1 - 1.2e-08 34.9 0.0 0.00089 18.8 0.0 2.3 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.2 EWC45915.1 - 0.0033 17.6 0.1 0.072 13.2 0.0 3.0 3 1 0 3 3 3 1 haloacid dehalogenase-like hydrolase Glyco_trans_1_4 PF13692.1 EWC45915.1 - 0.0065 16.6 0.0 0.016 15.3 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 NAD_kinase PF01513.16 EWC45915.1 - 0.025 13.3 0.0 0.084 11.6 0.0 1.8 2 0 0 2 2 2 0 ATP-NAD kinase zf-C2H2 PF00096.21 EWC45916.1 - 2.9e-05 24.1 12.9 0.0056 16.9 1.3 3.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 EWC45916.1 - 5.2e-05 23.3 5.5 5.2e-05 23.3 3.8 2.5 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_4 PF13894.1 EWC45916.1 - 0.016 15.4 16.9 0.025 14.8 0.9 3.3 3 0 0 3 3 3 0 C2H2-type zinc finger DUF2231 PF09990.4 EWC45917.1 - 0.00014 22.1 0.9 0.00023 21.4 0.6 1.3 1 0 0 1 1 1 1 Predicted membrane protein (DUF2231) HEV_ORF1 PF02444.11 EWC45917.1 - 0.004 17.3 0.2 0.0064 16.6 0.1 1.4 1 0 0 1 1 1 1 Hepatitis E virus ORF-2 (Putative capsid protein) DUF962 PF06127.6 EWC45917.1 - 0.036 13.9 0.1 0.083 12.7 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF962) Ni_hydr_CYTB PF01292.15 EWC45917.1 - 0.87 8.9 5.1 0.44 9.9 2.1 1.6 1 1 0 1 1 1 0 Prokaryotic cytochrome b561 DUF2817 PF10994.3 EWC45918.1 - 0.005 15.9 0.1 0.0063 15.6 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2817) DUF2142 PF09913.4 EWC45918.1 - 0.02 13.6 1.8 0.026 13.2 1.3 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2142) DC_STAMP PF07782.8 EWC45918.1 - 0.031 13.9 0.1 0.038 13.5 0.0 1.3 1 0 0 1 1 1 0 DC-STAMP-like protein Brr6_like_C_C PF10104.4 EWC45918.1 - 0.042 13.3 0.1 0.062 12.8 0.1 1.2 1 0 0 1 1 1 0 Di-sulfide bridge nucleocytoplasmic transport domain DUF2077 PF09850.4 EWC45918.1 - 0.049 13.0 0.6 0.073 12.4 0.4 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2077) DUF1705 PF08019.7 EWC45918.1 - 0.053 13.0 1.7 0.073 12.5 1.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1705) Pkinase PF00069.20 EWC45919.1 - 2.5e-74 249.7 0.0 3.2e-74 249.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC45919.1 - 4.8e-32 111.0 0.0 5.9e-32 110.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EWC45919.1 - 0.00075 18.5 0.0 0.0016 17.4 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 EWC45919.1 - 0.0022 17.0 0.1 0.0037 16.3 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 EWC45919.1 - 0.014 15.1 0.0 0.023 14.4 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 EWC45919.1 - 0.061 12.1 0.1 0.09 11.5 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Gag_p6 PF08705.6 EWC45919.1 - 0.097 12.7 0.8 0.19 11.7 0.6 1.4 1 0 0 1 1 1 0 Gag protein p6 Sec23_trunk PF04811.10 EWC45920.1 - 1.6e-75 253.6 0.0 2.6e-75 252.9 0.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.7 EWC45920.1 - 2.4e-18 66.3 0.1 5.7e-18 65.2 0.1 1.7 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.10 EWC45920.1 - 2.5e-18 65.3 3.0 2.7e-18 65.3 0.2 2.4 3 0 0 3 3 3 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.10 EWC45920.1 - 1e-17 63.4 4.7 1.9e-17 62.4 3.3 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.17 EWC45920.1 - 3.6e-11 42.5 0.0 6.5e-11 41.7 0.0 1.4 1 0 0 1 1 1 1 Gelsolin repeat EMG1 PF03587.9 EWC45921.1 - 9.8e-75 250.2 0.0 1.1e-74 250.0 0.0 1.0 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase Caprin-1_C PF12287.3 EWC45922.1 - 0.004 16.5 0.6 0.0084 15.5 0.4 1.5 1 0 0 1 1 1 1 Cytoplasmic activation/proliferation-associated protein-1 C term Helicase_C_2 PF13307.1 EWC45923.1 - 3.6e-58 196.1 0.0 1e-57 194.7 0.0 1.8 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD_2 PF06733.10 EWC45923.1 - 6.2e-43 146.1 0.5 1.5e-42 144.9 0.4 1.7 1 1 0 1 1 1 1 DEAD_2 HAUS6_N PF14661.1 EWC45923.1 - 0.054 12.8 2.6 2.4 7.4 1.8 2.8 3 0 0 3 3 3 0 HAUS augmin-like complex subunit 6 N-terminus DUF1556 PF07590.6 EWC45924.1 - 0.03 14.5 3.8 0.064 13.4 2.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1556) COG5 PF10392.4 EWC45926.1 - 3.2e-36 124.1 1.6 3.2e-36 124.1 1.1 2.6 3 0 0 3 3 3 1 Golgi transport complex subunit 5 Vps5 PF09325.5 EWC45926.1 - 0.25 10.5 1.5 3.6 6.7 0.1 2.3 2 0 0 2 2 2 0 Vps5 C terminal like MFS_1 PF07690.11 EWC45927.1 - 1.6e-06 27.0 31.3 5.7e-06 25.2 21.9 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily GWT1 PF06423.7 EWC45927.1 - 0.17 12.0 2.2 0.42 10.7 0.3 2.6 2 1 0 2 2 2 0 GWT1 SnoaL_2 PF12680.2 EWC45928.1 - 0.026 14.9 0.0 0.056 13.8 0.0 1.6 1 0 0 1 1 1 0 SnoaL-like domain GAF PF01590.21 EWC45930.1 - 3.7e-07 30.3 0.0 8.5e-07 29.2 0.0 1.6 1 0 0 1 1 1 1 GAF domain GAF_3 PF13492.1 EWC45930.1 - 4.4e-05 23.5 0.0 0.00012 22.1 0.0 1.8 1 0 0 1 1 1 1 GAF domain GAF_2 PF13185.1 EWC45930.1 - 0.00019 21.9 0.0 0.00049 20.6 0.0 1.7 1 0 0 1 1 1 1 GAF domain DPPIV_N PF00930.16 EWC45931.1 - 6.7e-108 360.4 0.3 9.3e-108 359.9 0.2 1.2 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.16 EWC45931.1 - 7.4e-55 185.4 2.6 1.1e-54 184.8 1.3 1.8 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 EWC45931.1 - 1.9e-08 34.1 0.1 4.4e-08 33.0 0.0 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 EWC45931.1 - 1.2e-06 28.6 0.0 2.2e-05 24.4 0.0 2.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S15 PF02129.13 EWC45931.1 - 3e-05 23.6 0.6 0.0049 16.3 0.1 2.4 1 1 1 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) Esterase PF00756.15 EWC45931.1 - 0.0042 16.5 0.0 0.0092 15.4 0.0 1.5 1 0 0 1 1 1 1 Putative esterase DLH PF01738.13 EWC45931.1 - 0.0052 16.0 0.0 0.042 13.1 0.0 2.0 1 1 0 1 1 1 1 Dienelactone hydrolase family Cgr1 PF03879.9 EWC45932.1 - 6.1e-31 106.8 18.3 7.3e-31 106.5 12.7 1.0 1 0 0 1 1 1 1 Cgr1 family TATR PF03430.8 EWC45932.1 - 0.39 9.3 8.6 0.43 9.1 6.0 1.0 1 0 0 1 1 1 0 Trans-activating transcriptional regulator DOR PF14839.1 EWC45932.1 - 9.3 5.9 14.1 11 5.6 9.8 1.1 1 0 0 1 1 1 0 DOR family Mito_carr PF00153.22 EWC45933.1 - 7.5e-29 99.2 0.5 1.1e-19 69.9 0.1 2.2 2 0 0 2 2 2 2 Mitochondrial carrier protein Ecm33 PF12454.3 EWC45933.1 - 0.084 12.7 0.4 0.22 11.4 0.3 1.7 1 0 0 1 1 1 0 GPI-anchored cell wall organization protein zf-GRF PF06839.7 EWC45934.1 - 2.7e-06 27.2 1.5 7.5e-06 25.7 1.0 1.8 1 0 0 1 1 1 1 GRF zinc finger CCDC155 PF14662.1 EWC45934.1 - 0.0011 18.6 8.9 0.0011 18.6 6.1 2.2 1 1 1 2 2 2 1 Coiled-coil region of CCDC155 Myosin_tail_1 PF01576.14 EWC45934.1 - 0.0039 14.9 14.9 0.0053 14.5 10.4 1.1 1 0 0 1 1 1 1 Myosin tail DivIC PF04977.10 EWC45934.1 - 0.007 15.8 16.3 0.022 14.2 1.6 4.0 2 1 2 4 4 4 1 Septum formation initiator CENP-F_leu_zip PF10473.4 EWC45934.1 - 0.0098 15.7 17.1 0.018 14.8 11.9 1.4 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF972 PF06156.8 EWC45934.1 - 0.039 14.2 11.2 0.38 11.1 2.1 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF972) IncA PF04156.9 EWC45934.1 - 0.074 12.6 11.9 0.17 11.4 8.3 1.6 1 0 0 1 1 1 0 IncA protein APG6 PF04111.7 EWC45934.1 - 0.084 11.9 11.8 0.13 11.2 8.2 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 TMF_DNA_bd PF12329.3 EWC45934.1 - 0.11 12.2 18.9 0.46 10.3 3.5 2.4 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding ADIP PF11559.3 EWC45934.1 - 0.13 12.2 11.7 0.064 13.1 5.3 2.1 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding ATG16 PF08614.6 EWC45934.1 - 0.15 11.8 15.0 0.61 9.8 10.3 2.0 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) CENP-Q PF13094.1 EWC45934.1 - 0.22 11.5 10.2 0.75 9.8 7.1 1.9 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit bZIP_1 PF00170.16 EWC45934.1 - 0.55 10.2 12.2 0.55 10.2 0.8 3.1 1 1 2 3 3 3 0 bZIP transcription factor DUF904 PF06005.7 EWC45934.1 - 0.94 9.8 20.9 0.5 10.7 4.7 3.1 1 1 1 2 2 2 0 Protein of unknown function (DUF904) CCDC92 PF14916.1 EWC45934.1 - 4 7.1 11.1 0.45 10.1 1.0 3.1 3 1 1 4 4 4 0 Coiled-coil domain of unknown function Mto2_bdg PF12808.2 EWC45934.1 - 4.7 7.3 12.9 2.9 8.0 0.3 4.2 3 1 1 4 4 3 0 Micro-tubular organiser Mto1 C-term Mto2-binding region Microtub_assoc PF07989.6 EWC45934.1 - 6.8 6.6 13.7 3.1 7.6 0.8 4.2 2 1 3 5 5 5 0 Microtubule associated V_ATPase_I PF01496.14 EWC45934.1 - 8.1 4.1 7.0 12 3.6 4.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family dCMP_cyt_deam_1 PF00383.17 EWC45935.1 - 1.9e-11 43.5 0.0 2.3e-11 43.2 0.0 1.1 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region dCMP_cyt_deam_2 PF08211.6 EWC45935.1 - 1.4e-10 41.2 0.1 4.8e-09 36.2 0.0 2.0 2 0 0 2 2 2 1 Cytidine and deoxycytidylate deaminase zinc-binding region DUF962 PF06127.6 EWC45936.1 - 1.6e-24 85.5 2.5 2.5e-24 84.9 1.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF962) DUF3852 PF12963.2 EWC45936.1 - 0.21 11.6 1.7 0.52 10.3 0.7 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3852) SHS2_Rpb7-N PF03876.12 EWC45937.1 - 1e-13 51.1 0.0 1.9e-13 50.2 0.0 1.5 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.18 EWC45937.1 - 1.9e-09 37.4 0.1 2.7e-09 36.9 0.0 1.2 1 0 0 1 1 1 1 S1 RNA binding domain ATP-synt_ab PF00006.20 EWC45938.1 - 1.4e-69 233.8 0.0 2.1e-69 233.3 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 EWC45938.1 - 7.7e-28 97.2 0.0 2e-27 95.9 0.0 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.18 EWC45938.1 - 3.2e-16 59.3 2.1 7.5e-16 58.1 1.4 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain HAS-barrel PF09378.5 EWC45938.1 - 0.00071 19.4 1.0 0.0017 18.2 0.7 1.7 1 0 0 1 1 1 1 HAS barrel domain Carb_kinase PF01256.12 EWC45939.1 - 6.1e-48 163.2 1.1 1.5e-37 129.2 0.0 2.2 1 1 1 2 2 2 2 Carbohydrate kinase Cpn60_TCP1 PF00118.19 EWC45941.1 - 1.1e-91 307.9 5.9 1.4e-91 307.5 4.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Tubulin PF00091.20 EWC45942.1 - 2.8e-63 213.6 0.0 3.7e-63 213.2 0.0 1.1 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.12 EWC45942.1 - 1.2e-43 148.1 0.0 1.8e-43 147.5 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.1 EWC45942.1 - 0.0031 17.0 0.0 0.0057 16.1 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain Lipase_3 PF01764.20 EWC45942.1 - 0.1 12.1 0.0 0.2 11.2 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) SUI1 PF01253.17 EWC45943.1 - 1.7e-22 79.0 1.0 2.9e-22 78.2 0.7 1.4 1 0 0 1 1 1 1 Translation initiation factor SUI1 Cytidylate_kin2 PF13189.1 EWC45943.1 - 0.011 15.6 2.6 0.17 11.8 0.0 2.1 2 0 0 2 2 2 0 Cytidylate kinase-like family PqqD PF05402.7 EWC45943.1 - 0.039 13.9 1.3 0.068 13.1 0.2 1.9 2 0 0 2 2 2 0 Coenzyme PQQ synthesis protein D (PqqD) eIF-3c_N PF05470.7 EWC45943.1 - 0.05 11.7 0.4 0.059 11.4 0.3 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus FAD_binding_2 PF00890.19 EWC45945.1 - 3.8e-125 417.9 2.6 4.9e-125 417.6 1.8 1.1 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.15 EWC45945.1 - 7e-46 155.2 0.2 1e-45 154.7 0.1 1.3 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term DAO PF01266.19 EWC45945.1 - 3.6e-06 26.1 0.1 0.0036 16.2 0.0 2.4 2 0 0 2 2 2 2 FAD dependent oxidoreductase Thi4 PF01946.12 EWC45945.1 - 6.6e-06 25.3 0.1 0.0079 15.3 0.0 2.6 3 0 0 3 3 3 2 Thi4 family Pyr_redox_2 PF07992.9 EWC45945.1 - 8.2e-06 25.8 3.0 0.0025 17.7 0.1 3.0 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 EWC45945.1 - 9e-06 24.7 1.3 0.014 14.2 1.5 2.2 2 0 0 2 2 2 2 Glucose inhibited division protein A FAD_binding_3 PF01494.14 EWC45945.1 - 0.0036 16.4 0.5 0.0077 15.3 0.1 1.7 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.9 EWC45945.1 - 0.11 10.9 1.1 0.24 9.7 0.4 1.8 2 0 0 2 2 2 0 HI0933-like protein AAA PF00004.24 EWC45946.1 - 7e-41 139.5 0.0 1.2e-40 138.8 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 EWC45946.1 - 2.6e-06 27.5 0.0 0.00046 20.3 0.0 2.9 2 1 0 2 2 2 1 AAA domain AAA_5 PF07728.9 EWC45946.1 - 1.1e-05 25.1 0.0 5e-05 23.0 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 EWC45946.1 - 8.9e-05 22.5 0.0 0.0004 20.4 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_2 PF07724.9 EWC45946.1 - 0.00023 21.1 0.0 0.00052 19.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.8 EWC45946.1 - 0.00057 18.8 0.0 0.001 18.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_17 PF13207.1 EWC45946.1 - 0.0016 19.2 0.1 0.0047 17.7 0.0 1.9 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.7 EWC45946.1 - 0.0022 17.0 0.0 0.0038 16.3 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_19 PF13245.1 EWC45946.1 - 0.0036 17.0 0.1 0.0068 16.1 0.1 1.4 1 0 0 1 1 1 1 Part of AAA domain Sigma54_activ_2 PF14532.1 EWC45946.1 - 0.01 15.8 0.0 0.025 14.6 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain Zeta_toxin PF06414.7 EWC45946.1 - 0.011 14.9 0.0 0.019 14.0 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_28 PF13521.1 EWC45946.1 - 0.011 15.6 0.0 0.019 14.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.1 EWC45946.1 - 0.012 15.5 0.0 0.024 14.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.1 EWC45946.1 - 0.013 15.3 0.0 0.025 14.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_3 PF07726.6 EWC45946.1 - 0.028 14.0 0.0 0.049 13.2 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.12 EWC45946.1 - 0.031 13.6 0.0 0.052 12.9 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein RNA_helicase PF00910.17 EWC45946.1 - 0.032 14.4 0.0 0.067 13.3 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_18 PF13238.1 EWC45946.1 - 0.046 14.0 0.1 0.13 12.5 0.0 1.8 2 0 0 2 2 1 0 AAA domain TIP49 PF06068.8 EWC45946.1 - 0.047 12.3 0.0 0.081 11.6 0.0 1.3 1 0 0 1 1 1 0 TIP49 C-terminus AAA_24 PF13479.1 EWC45946.1 - 0.054 13.0 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.16 EWC45946.1 - 0.058 12.5 0.0 0.11 11.6 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Arch_ATPase PF01637.13 EWC45946.1 - 0.061 13.0 0.0 5.1 6.7 0.0 2.5 1 1 1 2 2 2 0 Archaeal ATPase Sigma54_activat PF00158.21 EWC45946.1 - 0.074 12.5 0.0 0.19 11.1 0.0 1.7 2 0 0 2 2 1 0 Sigma-54 interaction domain DUF4164 PF13747.1 EWC45946.1 - 0.076 13.1 0.0 0.18 11.9 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) AAA_25 PF13481.1 EWC45946.1 - 0.1 12.0 0.1 0.31 10.4 0.0 1.7 1 1 0 2 2 2 0 AAA domain AAA_30 PF13604.1 EWC45946.1 - 0.11 12.0 0.0 0.57 9.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain ELMO_CED12 PF04727.8 EWC45947.1 - 6.1e-44 149.5 1.2 1.5e-43 148.3 0.8 1.7 1 0 0 1 1 1 1 ELMO/CED-12 family DUF3361 PF11841.3 EWC45947.1 - 0.00079 19.1 0.6 0.42 10.3 0.0 3.5 3 1 0 3 3 3 2 Domain of unknown function (DUF3361) DUF1752 PF08550.5 EWC45948.1 - 6.6e-10 38.3 4.3 1.2e-09 37.5 3.0 1.5 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) CPSF100_C PF13299.1 EWC45948.1 - 1 9.5 4.3 0.63 10.2 0.3 2.2 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal YL1 PF05764.8 EWC45948.1 - 1.5 8.3 6.9 1.1 8.7 0.5 2.3 2 0 0 2 2 2 0 YL1 nuclear protein GPI-anchored PF10342.4 EWC45949.1 - 1.2e-22 80.1 4.4 1.2e-22 80.1 3.0 2.2 2 1 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Rifin_STEVOR PF02009.11 EWC45949.1 - 1.3 8.6 3.5 1.4 8.4 2.5 1.2 1 0 0 1 1 1 0 Rifin/stevor family DUF4634 PF15465.1 EWC45949.1 - 1.6 8.9 5.3 7.4 6.7 3.7 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4634) SPT2 PF08243.6 EWC45951.1 - 3.6e-05 24.0 14.1 3.6e-05 24.0 9.8 2.6 3 1 0 3 3 3 1 SPT2 chromatin protein Pro_Al_protease PF02983.9 EWC45951.1 - 6 6.8 7.6 1.2 9.1 0.1 3.1 3 0 0 3 3 3 0 Alpha-lytic protease prodomain GRAB PF10375.4 EWC45952.1 - 0.13 12.0 0.1 0.24 11.1 0.1 1.4 1 0 0 1 1 1 0 GRIP-related Arf-binding domain Cys_Met_Meta_PP PF01053.15 EWC45953.1 - 2.7e-136 453.9 0.1 3e-136 453.7 0.1 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.12 EWC45953.1 - 2.1e-06 27.0 0.6 4.7e-06 25.8 0.4 1.5 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.16 EWC45953.1 - 3.4e-06 26.2 0.0 5e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 EWC45953.1 - 2.1e-05 23.8 0.1 6.5e-05 22.2 0.0 1.9 1 1 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.14 EWC45953.1 - 3.5e-05 22.7 0.3 7.4e-05 21.6 0.0 1.7 2 0 0 2 2 2 1 Aminotransferase class-V Ribosomal_60s PF00428.14 EWC45954.1 - 1.8e-24 85.9 4.2 2e-24 85.7 2.9 1.0 1 0 0 1 1 1 1 60s Acidic ribosomal protein Ribosomal_S19 PF00203.16 EWC45955.1 - 2.4e-33 113.5 0.5 3.5e-33 113.0 0.4 1.2 1 0 0 1 1 1 1 Ribosomal protein S19 Sds3 PF08598.6 EWC45956.1 - 1.3e-21 77.1 1.2 1.3e-21 77.1 0.8 3.8 2 2 0 2 2 2 1 Sds3-like RRM_1 PF00076.17 EWC45957.1 - 1.7e-22 78.8 0.0 1.4e-15 56.6 0.0 3.6 2 1 1 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EWC45957.1 - 2.7e-15 56.0 0.1 1.2e-10 41.1 0.0 3.6 2 1 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EWC45957.1 - 1.2e-11 44.2 0.0 2.9e-06 27.0 0.0 2.7 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MIP-T3 PF10243.4 EWC45957.1 - 3e-05 22.7 20.2 0.0033 15.9 14.0 2.1 1 1 0 1 1 1 1 Microtubule-binding protein MIP-T3 Spo7_2_N PF15407.1 EWC45957.1 - 0.1 12.1 0.0 0.42 10.1 0.0 1.9 2 0 0 2 2 2 0 Sporulation protein family 7 dNK PF01712.14 EWC45957.1 - 0.15 11.9 0.3 0.39 10.6 0.2 1.6 1 0 0 1 1 1 0 Deoxynucleoside kinase MMS19_C PF12460.3 EWC45959.1 - 5.5e-106 354.7 1.1 3.3e-104 348.9 0.0 2.6 2 1 0 2 2 2 1 RNAPII transcription regulator C-terminal MMS19_N PF14500.1 EWC45959.1 - 5e-88 294.7 1.2 6.8e-85 284.4 0.0 3.5 3 0 0 3 3 3 2 Dos2-interacting transcription regulator of RNA-Pol-II HEAT_EZ PF13513.1 EWC45959.1 - 3.4e-05 24.2 13.1 0.0046 17.4 0.3 7.3 6 2 2 8 8 8 2 HEAT-like repeat HEAT_2 PF13646.1 EWC45959.1 - 0.00012 22.3 0.5 0.00012 22.3 0.3 5.3 4 2 2 6 6 6 2 HEAT repeats HEAT PF02985.17 EWC45959.1 - 0.0016 18.3 4.3 1.6 9.0 0.1 5.0 4 0 0 4 4 4 1 HEAT repeat UME PF08064.8 EWC45959.1 - 0.0025 17.7 1.9 1.2 9.1 0.1 3.8 2 1 1 3 3 3 1 UME (NUC010) domain Proteasom_PSMB PF10508.4 EWC45959.1 - 0.0078 14.5 0.9 0.064 11.5 0.2 2.4 2 0 0 2 2 2 1 Proteasome non-ATPase 26S subunit Adaptin_N PF01602.15 EWC45959.1 - 0.073 11.3 7.8 0.5 8.6 0.5 3.5 3 1 1 4 4 4 0 Adaptin N terminal region THF_DHG_CYH PF00763.18 EWC45960.1 - 8.5e-18 64.4 0.0 1.4e-17 63.8 0.0 1.4 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain THF_DHG_CYH_C PF02882.14 EWC45960.1 - 1.2e-14 53.7 0.1 2e-12 46.5 0.0 2.8 1 1 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Brix PF04427.13 EWC45961.1 - 4.9e-37 127.4 0.1 6.3e-37 127.0 0.1 1.1 1 0 0 1 1 1 1 Brix domain Tim17 PF02466.14 EWC45962.1 - 1.3e-25 89.9 0.4 1.7e-25 89.4 0.3 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family BPD_transp_2 PF02653.11 EWC45962.1 - 0.0011 17.9 0.1 0.0017 17.3 0.0 1.2 1 0 0 1 1 1 1 Branched-chain amino acid transport system / permease component TMV_coat PF00721.16 EWC45962.1 - 0.029 14.3 0.0 0.047 13.6 0.0 1.3 1 0 0 1 1 1 0 Virus coat protein (TMV like) Nt_Gln_amidase PF09764.4 EWC45963.1 - 1.6e-39 135.1 1.0 1.2e-21 76.7 0.0 2.4 2 1 0 2 2 2 2 N-terminal glutamine amidase FliP PF00813.15 EWC45964.1 - 0.11 12.1 0.0 0.14 11.8 0.0 1.1 1 0 0 1 1 1 0 FliP family SET PF00856.23 EWC45965.1 - 8.7e-11 42.3 0.0 3.2e-08 34.0 0.0 2.3 2 0 0 2 2 2 2 SET domain zf-MYND PF01753.13 EWC45965.1 - 4.2e-08 32.9 9.5 4.2e-08 32.9 6.6 3.1 2 1 1 3 3 3 1 MYND finger DZR PF12773.2 EWC45965.1 - 0.0055 16.4 8.7 0.0055 16.4 6.1 2.6 2 1 0 2 2 2 1 Double zinc ribbon UPF0547 PF10571.4 EWC45965.1 - 0.15 11.7 9.6 0.036 13.7 2.5 2.6 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 TPR_11 PF13414.1 EWC45965.1 - 0.16 11.6 0.0 0.36 10.5 0.0 1.5 1 0 0 1 1 1 0 TPR repeat CBF PF03914.12 EWC45966.1 - 7.4e-44 149.0 0.5 1.6e-43 147.9 0.1 1.8 2 0 0 2 2 2 1 CBF/Mak21 family Inhibitor_I9 PF05922.11 EWC45966.1 - 0.11 13.0 0.1 0.25 11.9 0.1 1.6 1 0 0 1 1 1 0 Peptidase inhibitor I9 Mt_ATP-synt_B PF05405.9 EWC45967.1 - 1.6e-45 154.4 8.7 2e-45 154.1 6.0 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) Rep_trans PF02486.14 EWC45967.1 - 0.026 13.9 1.5 0.043 13.2 0.9 1.4 1 1 0 1 1 1 0 Replication initiation factor DUF2204 PF09970.4 EWC45968.1 - 1.6e-05 24.5 0.0 3e-05 23.5 0.0 1.4 1 1 0 1 1 1 1 Nucleotidyl transferase of unknown function (DUF2204) DUF1814 PF08843.6 EWC45968.1 - 0.00071 19.4 0.0 0.00095 19.0 0.0 1.3 1 0 0 1 1 1 1 Nucleotidyl transferase of unknown function (DUF1814) DUF3453 PF11935.3 EWC45969.1 - 2.1e-66 223.7 3.5 3.7e-66 222.9 1.7 1.9 3 0 0 3 3 3 1 Domain of unknown function (DUF3453) PBP PF01161.15 EWC45971.1 - 7e-28 97.3 0.0 9.3e-28 96.9 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein NUFIP1 PF10453.4 EWC45972.1 - 1.5e-11 43.5 6.4 1.5e-11 43.5 4.4 4.8 6 1 1 7 7 7 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) zf-CCCH PF00642.19 EWC45972.1 - 4.5e-05 23.0 1.1 7.9e-05 22.2 0.8 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 EWC45972.1 - 0.039 13.9 2.0 0.083 12.9 1.4 1.6 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type RNA_pol_Rbc25 PF08292.7 EWC45974.1 - 8.3e-41 139.0 0.0 1.1e-40 138.6 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.12 EWC45974.1 - 7e-15 54.9 0.0 1.2e-14 54.1 0.0 1.4 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.18 EWC45974.1 - 0.0031 17.5 0.5 0.0076 16.3 0.3 1.7 1 1 0 1 1 1 1 S1 RNA binding domain BNR PF02012.15 EWC45975.1 - 4e-14 50.0 35.6 1.1 9.3 0.2 11.0 10 0 0 10 10 10 8 BNR/Asp-box repeat CHB_HEX_C_1 PF13290.1 EWC45975.1 - 0.0021 17.8 4.1 0.02 14.6 0.1 3.6 3 0 0 3 3 3 1 Chitobiase/beta-hexosaminidase C-terminal domain FtsX PF02687.16 EWC45975.1 - 0.1 12.3 0.3 0.18 11.5 0.2 1.3 1 0 0 1 1 1 0 FtsX-like permease family DctQ PF04290.7 EWC45975.1 - 0.12 12.1 0.3 0.22 11.2 0.2 1.4 1 0 0 1 1 1 0 Tripartite ATP-independent periplasmic transporters, DctQ component Mur_ligase_M PF08245.7 EWC45976.1 - 1.4e-09 38.3 0.0 3.2e-09 37.0 0.0 1.7 1 1 0 1 1 1 1 Mur ligase middle domain Mur_ligase_C PF02875.16 EWC45976.1 - 0.00012 22.0 0.0 0.00023 21.1 0.0 1.4 1 0 0 1 1 1 1 Mur ligase family, glutamate ligase domain HECT_2 PF09814.4 EWC45977.1 - 4.6e-57 193.3 0.0 5.4e-57 193.1 0.0 1.0 1 0 0 1 1 1 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding Rubredoxin PF00301.15 EWC45977.1 - 0.052 13.4 1.7 0.13 12.1 0.1 2.2 2 0 0 2 2 2 0 Rubredoxin DUF3665 PF12427.3 EWC45977.1 - 1 8.7 3.5 0.71 9.2 0.4 2.2 2 0 0 2 2 2 0 Branched-chain amino acid aminotransferase Zn-ribbon_8 PF09723.5 EWC45977.1 - 1.3 9.0 3.4 0.61 10.0 0.4 1.9 2 0 0 2 2 2 0 Zinc ribbon domain DUF4243 PF14027.1 EWC45978.1 - 1.7e-65 221.6 0.5 2.1e-65 221.3 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4243) DUF1877 PF08974.5 EWC45978.1 - 0.034 13.7 0.0 0.064 12.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1877) TauD PF02668.11 EWC45979.1 - 2.6e-48 164.9 0.1 3.4e-48 164.5 0.1 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Dynamin_M PF01031.15 EWC45980.1 - 3.9e-113 377.1 0.0 7e-113 376.2 0.0 1.4 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.18 EWC45980.1 - 2.1e-55 187.0 0.0 4e-55 186.1 0.0 1.5 1 0 0 1 1 1 1 Dynamin family GED PF02212.13 EWC45980.1 - 3e-31 107.1 3.2 9e-31 105.6 2.3 1.9 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.18 EWC45980.1 - 0.00026 20.9 0.2 0.0018 18.2 0.2 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 EWC45980.1 - 0.0067 16.9 0.0 0.023 15.1 0.0 2.0 2 0 0 2 2 2 1 Miro-like protein UAA PF08449.6 EWC45984.1 - 8.8e-84 280.9 14.1 1.1e-83 280.7 9.8 1.0 1 0 0 1 1 1 1 UAA transporter family TPT PF03151.11 EWC45984.1 - 0.00055 19.6 3.2 0.00055 19.6 2.2 2.4 2 1 0 2 2 2 1 Triose-phosphate Transporter family EmrE PF13536.1 EWC45984.1 - 0.011 15.8 4.8 0.011 15.8 3.3 3.0 3 1 1 4 4 4 0 Multidrug resistance efflux transporter Nuc_sug_transp PF04142.10 EWC45984.1 - 0.034 13.2 9.9 0.018 14.1 3.5 2.5 2 1 1 3 3 3 0 Nucleotide-sugar transporter EamA PF00892.15 EWC45984.1 - 3.8 7.5 30.4 0.38 10.8 4.6 3.2 2 2 1 3 3 3 0 EamA-like transporter family IBN_N PF03810.14 EWC45985.1 - 0.13 12.1 0.1 0.44 10.4 0.0 2.0 1 1 0 1 1 1 0 Importin-beta N-terminal domain SPC25 PF06703.6 EWC45986.1 - 2.5e-44 150.7 0.1 3.3e-44 150.3 0.0 1.1 1 0 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) DUF106 PF01956.11 EWC45987.1 - 2.1e-58 196.5 2.2 3.1e-58 196.0 1.5 1.2 1 0 0 1 1 1 1 Integral membrane protein DUF106 Cytochrom_B_N PF00033.14 EWC45987.1 - 0.07 12.4 2.7 0.6 9.4 0.0 2.3 2 1 1 3 3 3 0 Cytochrome b(N-terminal)/b6/petB Pkinase PF00069.20 EWC45988.1 - 8.4e-63 211.9 0.0 9.5e-39 133.0 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 EWC45988.1 - 4.7e-27 94.6 0.0 2.8e-19 69.1 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Response_reg PF00072.19 EWC45988.1 - 3.2e-13 49.6 0.1 6.5e-13 48.6 0.1 1.6 1 0 0 1 1 1 1 Response regulator receiver domain Kinase-like PF14531.1 EWC45988.1 - 8.2e-07 28.2 0.0 4.8e-06 25.7 0.0 2.1 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 EWC45988.1 - 3.6e-05 23.6 0.0 0.0049 16.6 0.2 2.4 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 EWC45988.1 - 0.022 13.8 0.0 0.038 13.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.6 EWC45988.1 - 0.15 10.8 0.1 0.25 10.1 0.1 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Pox_ser-thr_kin PF05445.6 EWC45988.1 - 2.3 6.9 0.1 14 4.3 0.1 1.9 2 0 0 2 2 2 0 Poxvirus serine/threonine protein kinase CBFB_NFYA PF02045.10 EWC45989.1 - 9.1e-31 106.1 3.5 2.2e-30 104.9 2.4 1.7 1 0 0 1 1 1 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B Hus1 PF04005.7 EWC45989.1 - 0.17 10.8 0.0 0.26 10.1 0.0 1.2 1 0 0 1 1 1 0 Hus1-like protein Nbl1_Borealin_N PF10444.4 EWC45990.1 - 1.8e-07 30.4 1.4 4e-07 29.3 1.0 1.6 1 0 0 1 1 1 1 Nbl1 / Borealin N terminal VWA_2 PF13519.1 EWC45991.1 - 2e-13 50.8 0.0 2.8e-13 50.3 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain Ssl1 PF04056.9 EWC45991.1 - 4.2e-08 33.0 0.0 5.9e-08 32.5 0.0 1.1 1 0 0 1 1 1 1 Ssl1-like UIM PF02809.15 EWC45991.1 - 0.0013 18.1 1.3 0.0046 16.4 0.9 2.0 1 0 0 1 1 1 1 Ubiquitin interaction motif Kinesin PF00225.18 EWC45992.1 - 9.8e-110 366.3 0.0 1.7e-109 365.5 0.0 1.4 1 0 0 1 1 1 1 Kinesin motor domain DUF3694 PF12473.3 EWC45992.1 - 1.7e-34 118.5 0.3 3.1e-34 117.6 0.2 1.5 1 0 0 1 1 1 1 Kinesin protein PH PF00169.24 EWC45992.1 - 2.7e-11 43.5 0.0 6.4e-11 42.3 0.0 1.6 1 0 0 1 1 1 1 PH domain KIF1B PF12423.3 EWC45992.1 - 2e-06 27.7 0.1 4.8e-06 26.5 0.0 1.7 1 0 0 1 1 1 1 Kinesin protein 1B PH_9 PF15410.1 EWC45992.1 - 0.052 13.7 0.8 0.21 11.7 0.0 2.4 2 1 0 2 2 2 0 Pleckstrin homology domain AAA_22 PF13401.1 EWC45992.1 - 0.065 13.3 0.0 0.29 11.2 0.0 2.1 1 0 0 1 1 1 0 AAA domain B_lectin PF01453.19 EWC45993.1 - 7.9e-15 54.7 0.1 8.4e-09 35.3 0.0 2.0 1 1 1 2 2 2 2 D-mannose binding lectin Mito_carr PF00153.22 EWC45994.1 - 8e-60 198.5 0.2 6e-21 73.9 0.0 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein LRR_6 PF13516.1 EWC45995.1 - 2e-14 51.9 8.5 0.044 13.8 0.0 8.4 9 0 0 9 9 9 4 Leucine Rich repeat LRR_4 PF12799.2 EWC45995.1 - 4e-10 39.0 11.5 0.0031 17.0 0.1 6.4 4 2 3 7 7 7 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 EWC45995.1 - 3.8e-07 29.2 0.3 38 4.8 0.0 6.9 8 0 0 8 8 8 0 Leucine Rich Repeat LRR_8 PF13855.1 EWC45995.1 - 0.0013 18.4 10.5 0.5 10.1 0.1 5.4 5 1 0 5 5 5 2 Leucine rich repeat VID27 PF08553.5 EWC45995.1 - 2.3 6.3 9.2 3.3 5.8 6.4 1.1 1 0 0 1 1 1 0 VID27 cytoplasmic protein COX17 PF05051.8 EWC45996.1 - 7e-19 67.5 6.0 8.2e-19 67.3 4.2 1.1 1 0 0 1 1 1 1 Cytochrome C oxidase copper chaperone (COX17) Cmc1 PF08583.5 EWC45996.1 - 0.0066 16.1 1.7 1.8 8.4 0.2 2.1 1 1 1 2 2 2 2 Cytochrome c oxidase biogenesis protein Cmc1 like TAFII55_N PF04658.8 EWC45997.1 - 4.7e-51 172.5 0.1 9.9e-51 171.4 0.1 1.6 1 0 0 1 1 1 1 TAFII55 protein conserved region Bromo_TP PF07524.8 EWC45998.1 - 5.2e-14 51.7 0.0 8.9e-14 50.9 0.0 1.3 1 0 0 1 1 1 1 Bromodomain associated TrmB PF01978.14 EWC45998.1 - 0.041 13.5 0.0 0.086 12.5 0.0 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB PAP1 PF08601.5 EWC45999.1 - 0.1 12.3 0.0 0.14 11.8 0.0 1.2 1 0 0 1 1 1 0 Transcription factor PAP1 Sel1 PF08238.7 EWC46000.1 - 6.4e-18 64.7 6.7 3.2e-06 27.5 0.0 3.8 4 0 0 4 4 4 3 Sel1 repeat Alg6_Alg8 PF03155.10 EWC46001.1 - 4.8e-139 464.2 8.7 6.3e-139 463.8 6.0 1.1 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family Pkinase PF00069.20 EWC46002.1 - 6.9e-48 163.0 0.0 1e-47 162.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC46002.1 - 7e-23 81.0 0.0 1.1e-22 80.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EWC46002.1 - 0.0007 18.6 0.0 0.0012 17.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 EWC46002.1 - 0.0063 16.2 0.1 0.037 13.7 0.1 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 EWC46002.1 - 0.019 14.0 0.1 0.04 12.9 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PsaA_PsaB PF00223.14 EWC46002.1 - 0.048 11.7 0.0 0.07 11.2 0.0 1.1 1 0 0 1 1 1 0 Photosystem I psaA/psaB protein RIO1 PF01163.17 EWC46002.1 - 0.055 12.8 0.1 0.055 12.8 0.1 1.6 2 0 0 2 2 2 0 RIO1 family Choline_kinase PF01633.15 EWC46002.1 - 0.27 10.7 0.6 0.5 9.9 0.0 1.6 2 0 0 2 2 2 0 Choline/ethanolamine kinase bZIP_Maf PF03131.12 EWC46003.1 - 1.9e-06 28.0 6.6 1.9e-06 28.0 4.6 3.1 3 1 0 3 3 3 1 bZIP Maf transcription factor bZIP_1 PF00170.16 EWC46003.1 - 3.1e-06 27.0 10.2 3.1e-06 27.0 7.1 2.6 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.10 EWC46003.1 - 4.3e-05 23.2 10.3 4.3e-05 23.2 7.2 2.6 2 0 0 2 2 2 1 Basic region leucine zipper zf-CCCH PF00642.19 EWC46004.1 - 0.0021 17.6 5.5 0.0068 16.0 0.8 2.3 1 1 1 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3H1 PF10650.4 EWC46004.1 - 0.027 13.9 1.2 0.027 13.9 0.8 1.8 2 0 0 2 2 2 0 Putative zinc-finger domain Myc_N PF01056.13 EWC46004.1 - 0.11 11.6 2.3 0.13 11.3 1.6 1.1 1 0 0 1 1 1 0 Myc amino-terminal region DUF2457 PF10446.4 EWC46004.1 - 0.17 10.5 9.7 0.21 10.2 6.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) F-box-like PF12937.2 EWC46005.1 - 0.0089 15.7 0.0 0.019 14.7 0.0 1.6 1 0 0 1 1 1 1 F-box-like TFIIF_beta PF02270.10 EWC46006.1 - 2.3e-72 244.1 1.1 6.1e-72 242.7 0.7 1.6 1 1 0 1 1 1 1 Transcription initiation factor IIF, beta subunit DDE_Tnp_IS66_C PF13817.1 EWC46006.1 - 0.13 12.2 0.1 1.1 9.3 0.0 2.2 2 0 0 2 2 2 0 IS66 C-terminal element CutA1 PF03091.10 EWC46007.1 - 0.16 11.6 0.0 0.27 10.9 0.0 1.3 1 0 0 1 1 1 0 CutA1 divalent ion tolerance protein Ribosomal_S8e PF01201.17 EWC46008.1 - 2.4e-37 128.0 0.2 1.7e-36 125.2 0.2 1.9 1 1 0 1 1 1 1 Ribosomal protein S8e UQ_con PF00179.21 EWC46009.1 - 1.6e-09 37.3 1.1 5.4e-09 35.6 0.0 2.3 3 0 0 3 3 3 1 Ubiquitin-conjugating enzyme APC8 PF04049.8 EWC46009.1 - 0.0029 17.3 0.1 0.034 13.8 0.0 2.1 2 0 0 2 2 2 1 Anaphase promoting complex subunit 8 / Cdc23 UQ_con PF00179.21 EWC46010.1 - 5.7e-06 25.8 0.0 6.6e-06 25.5 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RhoGAP PF00620.22 EWC46011.1 - 2.6e-36 124.5 0.0 6e-36 123.3 0.0 1.6 1 0 0 1 1 1 1 RhoGAP domain LIM PF00412.17 EWC46011.1 - 6.1e-30 103.0 42.7 2.2e-12 46.8 5.8 5.3 5 0 0 5 5 5 4 LIM domain DUF3620 PF12281.3 EWC46011.1 - 0.046 13.4 0.2 8.3 6.0 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3620) ORC3_N PF07034.6 EWC46013.1 - 6.2e-46 156.8 0.1 2.2e-45 155.0 0.1 1.9 1 1 0 1 1 1 1 Origin recognition complex (ORC) subunit 3 N-terminus Xpo1 PF08389.7 EWC46013.1 - 0.026 14.4 1.2 11 5.9 0.0 3.8 3 1 0 3 3 3 0 Exportin 1-like protein TBPIP PF07106.8 EWC46013.1 - 0.091 12.3 0.5 0.23 11.0 0.0 1.9 2 0 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Syntaxin_2 PF14523.1 EWC46013.1 - 1.3 9.1 7.7 1.1 9.3 0.1 3.1 3 0 0 3 3 3 0 Syntaxin-like protein Peptidase_M43 PF05572.8 EWC46014.1 - 8.2e-16 57.9 0.0 1.3e-15 57.2 0.0 1.3 1 0 0 1 1 1 1 Pregnancy-associated plasma protein-A Reprolysin_2 PF13574.1 EWC46014.1 - 5.3e-06 26.5 0.1 8.8e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.1 EWC46014.1 - 0.00019 21.4 0.9 0.00051 20.0 0.6 1.8 1 1 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.1 EWC46014.1 - 0.00077 19.9 0.0 0.0017 18.9 0.0 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.1 EWC46014.1 - 0.0024 17.4 0.1 0.0049 16.4 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.19 EWC46014.1 - 0.0035 17.0 0.0 0.0051 16.5 0.0 1.4 1 0 0 1 1 1 1 Matrixin Peptidase_M66 PF10462.4 EWC46014.1 - 0.028 13.2 0.3 0.046 12.5 0.2 1.2 1 0 0 1 1 1 0 Peptidase M66 NAAA-beta PF15508.1 EWC46016.1 - 1.8e-20 73.0 0.0 2.9e-20 72.4 0.0 1.3 1 0 0 1 1 1 1 beta subunit of N-acylethanolamine-hydrolyzing acid amidase NUDIX PF00293.23 EWC46017.1 - 6.5e-12 45.2 0.2 3.5e-10 39.6 0.1 2.7 1 1 0 1 1 1 1 NUDIX domain NfeD PF01957.13 EWC46018.1 - 0.054 13.6 0.3 0.081 13.0 0.2 1.2 1 0 0 1 1 1 0 NfeD-like C-terminal, partner-binding DUF4191 PF13829.1 EWC46018.1 - 0.11 11.6 0.3 0.2 10.7 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) Vma12 PF11712.3 EWC46018.1 - 6.2 6.5 5.3 18 5.0 3.7 2.0 1 1 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Myelin_MBP PF01669.12 EWC46019.1 - 0.055 13.7 0.2 0.064 13.5 0.1 1.2 1 0 0 1 1 1 0 Myelin basic protein MT0933_antitox PF14013.1 EWC46019.1 - 2.3 8.3 10.7 27 4.9 7.4 2.4 1 1 0 1 1 1 0 MT0933-like antitoxin protein PAN_1 PF00024.21 EWC46023.1 - 6.6e-05 22.5 2.6 0.19 11.4 0.2 2.4 2 0 0 2 2 2 2 PAN domain PAN_2 PF08276.6 EWC46023.1 - 0.2 11.5 0.2 0.2 11.5 0.2 2.6 2 1 0 2 2 2 0 PAN-like domain PAN_1 PF00024.21 EWC46024.1 - 1.6e-06 27.7 2.6 0.0082 15.8 0.1 2.2 2 0 0 2 2 2 2 PAN domain PAN_4 PF14295.1 EWC46024.1 - 0.0034 17.0 1.0 0.0034 17.0 0.7 2.5 2 1 0 2 2 2 1 PAN domain SE PF08491.5 EWC46027.1 - 1.6e-107 358.4 0.0 2e-107 358.1 0.0 1.1 1 0 0 1 1 1 1 Squalene epoxidase FAD_binding_3 PF01494.14 EWC46027.1 - 4.7e-13 48.9 0.0 7.3e-13 48.2 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.19 EWC46027.1 - 4e-10 39.1 0.2 3.2e-05 22.9 0.1 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 EWC46027.1 - 3.9e-05 22.6 1.9 0.14 10.9 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain Trp_halogenase PF04820.9 EWC46027.1 - 0.00059 18.5 0.0 0.33 9.5 0.0 2.1 2 0 0 2 2 2 2 Tryptophan halogenase NAD_Gly3P_dh_N PF01210.18 EWC46027.1 - 0.0027 17.4 0.0 0.0052 16.5 0.0 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_binding_8 PF13450.1 EWC46027.1 - 0.0036 17.3 0.4 0.0076 16.2 0.3 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain ApbA PF02558.11 EWC46027.1 - 0.0084 15.5 0.3 0.016 14.6 0.2 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA 3HCDH_N PF02737.13 EWC46027.1 - 0.013 15.2 0.1 0.026 14.1 0.1 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.9 EWC46027.1 - 0.014 15.2 0.0 0.024 14.5 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 EWC46027.1 - 0.026 13.6 0.0 0.41 9.7 0.0 2.1 2 0 0 2 2 2 0 Thi4 family GIDA PF01134.17 EWC46027.1 - 0.027 13.3 0.1 0.044 12.6 0.0 1.3 1 1 0 1 1 1 0 Glucose inhibited division protein A F420_oxidored PF03807.12 EWC46027.1 - 0.075 13.4 0.2 0.19 12.1 0.1 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent UDPG_MGDP_dh_N PF03721.9 EWC46027.1 - 0.085 12.2 0.0 0.15 11.4 0.0 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Pyr_redox PF00070.22 EWC46027.1 - 0.092 13.1 0.3 0.29 11.5 0.2 1.9 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.15 EWC46027.1 - 0.11 12.6 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase FAD_oxidored PF12831.2 EWC46027.1 - 0.15 11.1 1.1 0.22 10.5 0.7 1.3 1 1 0 1 1 1 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.7 EWC46027.1 - 0.17 10.7 0.3 0.43 9.4 0.3 1.6 2 0 0 2 2 2 0 Lycopene cyclase protein HI0933_like PF03486.9 EWC46027.1 - 0.17 10.2 0.1 0.25 9.7 0.1 1.2 1 0 0 1 1 1 0 HI0933-like protein NUDIX PF00293.23 EWC46031.1 - 1e-16 60.7 0.0 2.1e-16 59.7 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain p450 PF00067.17 EWC46032.1 - 1.9e-79 267.3 0.0 2.3e-79 267.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 FAD_binding_8 PF08022.7 EWC46036.1 - 1.7e-13 50.3 0.0 1.4e-12 47.4 0.0 2.2 1 1 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.14 EWC46036.1 - 1.5e-11 44.4 13.1 2.8e-11 43.5 8.0 2.3 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.7 EWC46036.1 - 7e-11 42.2 0.0 2.1e-10 40.6 0.0 1.8 1 1 0 1 1 1 1 Ferric reductase NAD binding domain Imm37 PF15598.1 EWC46037.1 - 0.074 12.9 0.0 0.19 11.6 0.0 1.6 1 1 0 1 1 1 0 Immunity protein 37 DUF374 PF04028.8 EWC46038.1 - 0.089 12.0 0.0 0.17 11.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF374) RNA_pol_Rpb5_C PF01191.14 EWC46042.1 - 4.2e-34 115.9 0.2 8.9e-34 114.9 0.2 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.9 EWC46042.1 - 1.1e-32 112.3 0.4 3.3e-32 110.7 0.1 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb5, N-terminal domain Mrr_cat PF04471.7 EWC46042.1 - 0.062 13.1 0.0 0.66 9.7 0.0 2.3 2 0 0 2 2 2 0 Restriction endonuclease AAA_3 PF07726.6 EWC46042.1 - 0.11 12.0 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF3584 PF12128.3 EWC46043.1 - 0.039 11.3 44.7 0.013 12.8 22.2 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF3584) DUF342 PF03961.8 EWC46043.1 - 0.32 9.3 33.8 0.096 11.0 4.8 3.6 2 1 2 4 4 4 0 Protein of unknown function (DUF342) DEAD PF00270.24 EWC46044.1 - 5.3e-41 139.9 0.0 7.8e-41 139.3 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EWC46044.1 - 1.6e-20 72.7 0.2 4.2e-20 71.3 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF1253 PF06862.7 EWC46044.1 - 0.00077 17.9 0.1 0.067 11.5 0.0 2.4 3 0 0 3 3 3 2 Protein of unknown function (DUF1253) ResIII PF04851.10 EWC46044.1 - 0.0024 17.7 0.0 0.0081 16.0 0.0 1.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit GTP1_OBG PF01018.17 EWC46045.1 - 3.5e-37 127.4 7.3 1e-29 103.1 2.6 2.6 2 0 0 2 2 2 2 GTP1/OBG MMR_HSR1 PF01926.18 EWC46045.1 - 3.1e-20 72.2 0.0 6.1e-20 71.3 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 EWC46045.1 - 3.1e-08 33.0 0.1 7.1e-08 31.8 0.1 1.6 1 1 0 1 1 1 1 Ferrous iron transport protein B 2OG-FeII_Oxy PF03171.15 EWC46047.1 - 0.00029 21.0 0.6 0.029 14.6 0.0 2.7 3 0 0 3 3 3 2 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_2 PF13532.1 EWC46048.1 - 3.5e-29 102.0 0.0 4.8e-29 101.5 0.0 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 EWC46048.1 - 0.00025 21.2 0.0 0.0038 17.5 0.0 2.2 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily zf-GRF PF06839.7 EWC46048.1 - 0.0013 18.5 3.0 0.007 16.2 2.1 2.1 1 1 0 1 1 1 1 GRF zinc finger CUE PF02845.11 EWC46048.1 - 0.013 14.9 0.1 0.029 13.8 0.1 1.5 1 0 0 1 1 1 0 CUE domain WD40 PF00400.27 EWC46049.1 - 1.5e-23 81.7 17.5 5.8e-08 32.3 0.0 6.6 7 0 0 7 7 7 6 WD domain, G-beta repeat Methyltransf_11 PF08241.7 EWC46050.1 - 1e-06 29.1 0.0 2.9e-06 27.6 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EWC46050.1 - 0.00039 20.1 0.0 0.00046 19.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EWC46050.1 - 0.022 15.2 0.0 0.061 13.7 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_18 PF12847.2 EWC46050.1 - 0.045 14.3 0.0 0.087 13.4 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_26 PF13659.1 EWC46050.1 - 0.053 13.5 0.0 0.17 11.9 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.1 EWC46050.1 - 0.053 13.8 0.0 0.11 12.8 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain MFS_1 PF07690.11 EWC46051.1 - 2.5e-31 108.7 20.4 2.5e-31 108.7 14.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EWC46051.1 - 1.4e-08 33.7 3.5 1.4e-08 33.7 2.4 2.1 2 0 0 2 2 2 1 Sugar (and other) transporter Auxin_repressed PF05564.7 EWC46051.1 - 3.9 8.1 8.2 5.7 7.5 2.5 2.3 1 1 1 2 2 2 0 Dormancy/auxin associated protein CDC45 PF02724.9 EWC46052.1 - 2.7e-167 557.5 29.3 8.1e-138 460.1 0.0 4.6 1 1 0 2 2 2 2 CDC45-like protein Nop14 PF04147.7 EWC46052.1 - 0.00059 17.9 32.2 0.00062 17.8 9.3 2.1 2 0 0 2 2 2 2 Nop14-like family SGT1 PF07093.6 EWC46052.1 - 0.0058 15.0 0.1 0.0058 15.0 0.1 2.1 2 0 0 2 2 2 1 SGT1 protein BSP_II PF05432.6 EWC46052.1 - 0.034 13.4 26.4 0.083 12.1 9.9 2.3 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) AAA_31 PF13614.1 EWC46052.1 - 0.13 12.2 0.0 0.26 11.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain FLO_LFY PF01698.11 EWC46052.1 - 0.38 9.5 17.9 0.01 14.7 3.2 2.2 2 0 0 2 2 2 0 Floricaula / Leafy protein BHD_2 PF10404.4 EWC46052.1 - 0.83 10.0 7.3 3.3 8.0 5.1 2.0 1 0 0 1 1 1 0 Rad4 beta-hairpin domain 2 Tim54 PF11711.3 EWC46052.1 - 2.4 6.6 11.2 0.15 10.5 1.4 2.1 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 RCC1_2 PF13540.1 EWC46052.1 - 3 7.5 6.4 0.39 10.4 0.9 2.1 2 0 0 2 2 2 0 Regulator of chromosome condensation (RCC1) repeat BUD22 PF09073.5 EWC46052.1 - 8.3 5.3 48.7 0.3 10.1 17.7 2.2 2 0 0 2 2 2 0 BUD22 FAM60A PF15396.1 EWC46052.1 - 9 5.9 13.0 0.66 9.6 2.5 2.3 2 0 0 2 2 2 0 Protein Family FAM60A DUF3129 PF11327.3 EWC46053.1 - 1.4e-55 187.9 16.2 1.4e-55 187.9 11.2 2.1 2 1 0 2 2 2 1 Protein of unknown function (DUF3129) Collagen PF01391.13 EWC46053.1 - 0.0011 18.4 35.5 0.0011 18.4 24.6 4.9 2 1 1 3 3 3 1 Collagen triple helix repeat (20 copies) Metal_resist PF13801.1 EWC46054.1 - 2.3 8.2 7.7 0.46 10.4 0.1 2.6 2 1 1 3 3 3 0 Heavy-metal resistance EBP PF05241.7 EWC46057.1 - 1e-05 24.6 2.2 1e-05 24.6 1.5 1.7 1 1 1 2 2 2 1 Emopamil binding protein DUF2781 PF10914.3 EWC46057.1 - 0.19 11.5 3.7 0.071 12.8 0.8 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2781) Pkinase PF00069.20 EWC46058.1 - 4.9e-35 120.9 0.0 1.7e-34 119.1 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Ank_2 PF12796.2 EWC46058.1 - 2.4e-28 98.2 0.0 1.3e-12 47.8 0.0 3.4 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.1 EWC46058.1 - 3.7e-22 77.8 0.1 3.3e-10 39.8 0.0 4.1 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.25 EWC46058.1 - 1.1e-21 75.5 0.1 1.3e-08 34.2 0.0 5.7 6 0 0 6 6 6 2 Ankyrin repeat Pkinase_Tyr PF07714.12 EWC46058.1 - 6.4e-21 74.5 0.0 1.9e-20 73.0 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Ank_4 PF13637.1 EWC46058.1 - 2.2e-20 72.6 0.2 2.8e-07 30.8 0.0 5.1 1 1 4 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 EWC46058.1 - 3.4e-16 57.7 0.1 0.00027 20.8 0.0 5.9 6 0 0 6 6 6 2 Ankyrin repeat Shigella_OspC PF06128.6 EWC46058.1 - 0.0013 18.2 0.0 0.095 12.1 0.0 2.8 3 0 0 3 3 3 1 Shigella flexneri OspC protein Kinase-like PF14531.1 EWC46058.1 - 0.055 12.4 0.0 2.1 7.2 0.0 2.2 2 0 0 2 2 2 0 Kinase-like Fungal_trans PF04082.13 EWC46060.1 - 5.9e-28 97.4 0.0 8.7e-28 96.9 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EWC46060.1 - 3.1e-10 39.7 10.3 5.1e-10 39.0 7.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RdRP PF05183.7 EWC46061.1 - 1.3e-152 509.4 0.0 1.8e-152 509.0 0.0 1.1 1 0 0 1 1 1 1 RNA dependent RNA polymerase Cation_efflux PF01545.16 EWC46061.1 - 7.1e-49 166.4 9.0 7.1e-49 166.4 6.3 2.7 3 0 0 3 3 3 1 Cation efflux family Zip PF02535.17 EWC46061.1 - 0.00095 18.2 12.9 0.00095 18.2 9.0 3.5 3 1 0 3 3 3 1 ZIP Zinc transporter BOF PF04076.8 EWC46061.1 - 0.1 12.4 0.0 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 Bacterial OB fold (BOF) protein Nop14 PF04147.7 EWC46061.1 - 3.8 5.3 5.3 6.2 4.6 3.7 1.2 1 0 0 1 1 1 0 Nop14-like family DUF1014 PF06244.7 EWC46062.1 - 6.5e-19 68.3 0.1 6.5e-19 68.3 0.1 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1014) FAD_binding_8 PF08022.7 EWC46063.1 - 1.2e-13 50.8 0.0 1.9e-13 50.1 0.0 1.3 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.14 EWC46063.1 - 5.9e-11 42.5 11.7 5.9e-11 42.5 8.1 1.9 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.7 EWC46063.1 - 5.6e-10 39.3 0.0 9.5e-06 25.5 0.0 2.4 2 0 0 2 2 2 2 Ferric reductase NAD binding domain His_Phos_1 PF00300.17 EWC46063.1 - 9.9e-05 22.4 0.0 0.00045 20.3 0.0 2.1 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) TIMELESS_C PF05029.8 EWC46063.1 - 0.37 9.6 1.1 0.56 9.0 0.8 1.1 1 0 0 1 1 1 0 Timeless protein C terminal region DUF2235 PF09994.4 EWC46064.1 - 1e-64 218.6 0.0 1.3e-62 211.7 0.0 2.1 2 0 0 2 2 2 2 Uncharacterized alpha/beta hydrolase domain (DUF2235) Zn_clus PF00172.13 EWC46065.1 - 1.8e-08 34.1 9.7 3.4e-08 33.2 6.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.3 EWC46065.1 - 0.0057 15.3 0.1 0.0084 14.7 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain LysM PF01476.15 EWC46069.1 - 1.2e-07 31.4 0.1 2.2e-07 30.6 0.0 1.4 1 0 0 1 1 1 1 LysM domain DUF4538 PF15061.1 EWC46070.1 - 2 7.7 6.1 7.1 6.0 0.1 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4538) Mito_carr PF00153.22 EWC46072.1 - 6e-62 205.3 7.1 9.6e-22 76.5 0.3 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Tox-WTIP PF15654.1 EWC46072.1 - 1 9.0 3.3 1.2 8.8 0.4 2.5 1 1 1 2 2 2 0 Toxin with a conserved tryptophan and TIP tripeptide motif Kinesin PF00225.18 EWC46073.1 - 3.8e-112 374.3 0.4 7.5e-112 373.3 0.2 1.5 1 0 0 1 1 1 1 Kinesin motor domain Nol1_Nop2_Fmu PF01189.12 EWC46074.1 - 2.1e-31 109.3 0.0 7e-21 74.8 0.0 3.8 2 1 1 3 3 3 3 NOL1/NOP2/sun family Methyltransf_26 PF13659.1 EWC46074.1 - 0.013 15.5 0.0 0.041 13.8 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain FtsJ PF01728.14 EWC46074.1 - 0.11 12.4 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 FtsJ-like methyltransferase GAS PF13851.1 EWC46075.1 - 0.00039 19.6 20.6 0.068 12.3 5.7 2.2 1 1 1 2 2 2 2 Growth-arrest specific micro-tubule binding Filament PF00038.16 EWC46075.1 - 0.0059 16.1 4.2 0.0059 16.1 2.9 2.3 1 1 1 2 2 2 1 Intermediate filament protein DUF972 PF06156.8 EWC46075.1 - 0.0067 16.7 16.0 0.1 12.9 2.6 2.5 1 1 1 2 2 2 2 Protein of unknown function (DUF972) WD40_alt PF14077.1 EWC46075.1 - 0.011 15.3 0.3 0.011 15.3 0.2 2.9 3 0 0 3 3 3 0 Alternative WD40 repeat motif HALZ PF02183.13 EWC46075.1 - 0.018 14.7 12.3 1.3 8.7 0.1 3.9 3 1 0 3 3 3 0 Homeobox associated leucine zipper DivIC PF04977.10 EWC46075.1 - 0.027 13.9 15.9 0.039 13.4 0.2 3.6 2 1 2 4 4 4 0 Septum formation initiator DUF743 PF05332.6 EWC46075.1 - 0.038 13.9 2.0 5.5 6.9 0.7 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF743) Herpes_BLRF2 PF05812.7 EWC46075.1 - 0.043 13.6 0.2 0.043 13.6 0.1 2.6 2 1 0 2 2 2 0 Herpesvirus BLRF2 protein Striatin PF08232.7 EWC46075.1 - 0.045 14.0 17.4 3.2 8.0 1.0 3.3 1 1 1 2 2 2 0 Striatin family AAA_13 PF13166.1 EWC46075.1 - 0.048 12.1 13.4 0.1 11.0 2.3 2.0 1 1 1 2 2 2 0 AAA domain IFP_35_N PF07334.8 EWC46075.1 - 0.077 12.9 0.6 0.077 12.9 0.4 3.3 2 1 1 3 3 3 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus DUF4618 PF15397.1 EWC46075.1 - 0.15 11.3 15.8 4.1 6.6 11.0 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4618) CENP-F_leu_zip PF10473.4 EWC46075.1 - 0.37 10.6 24.7 2.2 8.1 5.4 2.3 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 BLOC1_2 PF10046.4 EWC46075.1 - 0.4 10.8 9.8 0.12 12.4 0.7 3.1 1 1 2 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF349 PF03993.7 EWC46075.1 - 0.4 10.8 5.7 1.5 9.0 4.0 2.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF349) ADIP PF11559.3 EWC46075.1 - 0.41 10.5 21.1 0.81 9.5 0.2 3.1 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding bZIP_2 PF07716.10 EWC46075.1 - 0.53 10.1 15.9 1.1 9.1 0.0 4.2 2 1 2 4 4 4 0 Basic region leucine zipper bZIP_1 PF00170.16 EWC46075.1 - 0.55 10.2 21.0 0.52 10.3 0.1 4.0 1 1 2 3 3 2 0 bZIP transcription factor DUF724 PF05266.9 EWC46075.1 - 0.56 9.8 18.5 0.037 13.6 1.7 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF724) DUF3818 PF12825.2 EWC46075.1 - 0.56 8.8 6.1 0.98 8.0 4.1 1.5 1 1 0 1 1 1 0 Domain of unknown function in PX-proteins (DUF3818) Reo_sigmaC PF04582.7 EWC46075.1 - 0.77 8.8 4.1 0.92 8.6 0.3 1.9 1 1 1 2 2 2 0 Reovirus sigma C capsid protein SPX PF03105.14 EWC46075.1 - 0.83 9.3 11.4 1.2 8.7 7.9 1.2 1 0 0 1 1 1 0 SPX domain DUF904 PF06005.7 EWC46075.1 - 0.9 9.8 25.6 0.46 10.8 0.7 3.8 1 1 2 3 3 2 0 Protein of unknown function (DUF904) TMF_TATA_bd PF12325.3 EWC46075.1 - 1.1 9.0 20.3 0.27 10.9 3.8 2.4 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding Fib_alpha PF08702.5 EWC46075.1 - 1.6 8.8 9.4 2.7 8.1 0.0 2.5 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Prefoldin_2 PF01920.15 EWC46075.1 - 2.6 7.8 20.8 4.2 7.1 0.0 4.2 1 1 3 4 4 4 0 Prefoldin subunit PLRV_ORF5 PF01690.12 EWC46075.1 - 2.6 7.0 4.9 3.3 6.7 3.4 1.1 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein FlaC_arch PF05377.6 EWC46075.1 - 3 7.8 11.7 0.32 10.9 0.2 3.4 3 1 1 4 4 3 0 Flagella accessory protein C (FlaC) DUF4140 PF13600.1 EWC46075.1 - 3.8 8.0 14.7 4 7.9 0.1 3.5 2 1 1 3 3 3 0 N-terminal domain of unknown function (DUF4140) DUF2730 PF10805.3 EWC46075.1 - 4 7.2 9.7 0.77 9.5 0.2 3.0 1 1 1 3 3 3 0 Protein of unknown function (DUF2730) IncA PF04156.9 EWC46075.1 - 4.4 6.8 25.5 0.41 10.2 5.7 2.1 1 1 1 2 2 2 0 IncA protein APG6 PF04111.7 EWC46075.1 - 4.7 6.1 22.4 8.8 5.2 4.8 2.1 1 1 1 2 2 2 0 Autophagy protein Apg6 DUF4446 PF14584.1 EWC46075.1 - 4.7 7.0 11.8 3.5 7.4 1.2 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF4446) YlqD PF11068.3 EWC46075.1 - 5.5 7.0 13.3 2.4 8.1 1.4 2.5 1 1 1 2 2 2 0 YlqD protein Herpes_BLRF2 PF05812.7 EWC46076.1 - 0.0005 19.8 1.4 0.00094 18.9 1.0 1.4 1 0 0 1 1 1 1 Herpesvirus BLRF2 protein ERM PF00769.14 EWC46076.1 - 0.044 13.3 6.2 0.046 13.2 4.3 1.0 1 0 0 1 1 1 0 Ezrin/radixin/moesin family Mer2 PF09074.5 EWC46076.1 - 0.045 13.6 2.0 0.11 12.3 1.4 1.7 1 1 0 1 1 1 0 Mer2 ADIP PF11559.3 EWC46076.1 - 0.05 13.5 5.2 0.069 13.0 3.6 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding OmpH PF03938.9 EWC46076.1 - 0.054 13.4 2.4 0.069 13.0 1.7 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DivIC PF04977.10 EWC46076.1 - 0.06 12.8 6.0 0.16 11.4 4.0 1.7 1 1 1 2 2 2 0 Septum formation initiator bZIP_2 PF07716.10 EWC46076.1 - 0.12 12.2 5.9 0.41 10.5 4.1 2.1 1 1 0 1 1 1 0 Basic region leucine zipper ZapA PF05164.8 EWC46076.1 - 0.15 12.0 2.7 0.2 11.6 1.9 1.2 1 0 0 1 1 1 0 Cell division protein ZapA DUF148 PF02520.12 EWC46076.1 - 0.15 11.8 1.0 0.23 11.2 0.6 1.4 1 1 0 1 1 1 0 Domain of unknown function DUF148 DUF972 PF06156.8 EWC46076.1 - 0.18 12.1 1.8 0.26 11.6 1.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF972) DUF3552 PF12072.3 EWC46076.1 - 0.18 11.0 7.5 0.22 10.7 5.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) DUF3186 PF11382.3 EWC46076.1 - 0.18 10.8 1.8 0.24 10.4 1.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3186) Bacillus_HBL PF05791.6 EWC46076.1 - 0.19 11.0 2.7 0.24 10.7 1.9 1.1 1 0 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) UPF0184 PF03670.8 EWC46076.1 - 0.28 11.4 4.5 1.1 9.5 3.1 1.9 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0184) Phage_GP20 PF06810.6 EWC46076.1 - 0.6 9.5 5.0 0.76 9.2 3.5 1.2 1 0 0 1 1 1 0 Phage minor structural protein GP20 DUF724 PF05266.9 EWC46076.1 - 2.4 7.7 6.7 2.9 7.4 3.6 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF724) Cwf_Cwc_15 PF04889.7 EWC46076.1 - 2.5 7.7 8.0 3.7 7.1 5.6 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF812 PF05667.6 EWC46076.1 - 2.7 6.3 6.6 3.3 6.1 4.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) IncA PF04156.9 EWC46076.1 - 3 7.4 6.2 4.2 6.9 4.3 1.2 1 0 0 1 1 1 0 IncA protein HALZ PF02183.13 EWC46077.1 - 0.0013 18.4 33.3 0.18 11.5 0.3 8.6 7 1 2 9 9 9 3 Homeobox associated leucine zipper BLOC1_2 PF10046.4 EWC46077.1 - 0.075 13.1 9.8 0.19 11.8 0.7 3.6 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF743 PF05332.6 EWC46077.1 - 0.65 9.9 4.2 0.39 10.6 0.2 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF743) DUF2360 PF10152.4 EWC46077.1 - 0.96 9.7 5.7 3.2 8.0 3.9 2.1 1 1 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) Herpes_BLRF2 PF05812.7 EWC46077.1 - 1.1 9.0 21.8 1.4 8.7 0.1 5.4 4 2 2 6 6 6 0 Herpesvirus BLRF2 protein bZIP_1 PF00170.16 EWC46077.1 - 1.6 8.7 35.2 1.1 9.2 0.5 7.7 5 1 3 8 8 8 0 bZIP transcription factor Viral_P18 PF04521.8 EWC46077.1 - 1.7 8.1 11.8 4 6.8 0.1 3.4 3 0 0 3 3 3 0 ssRNA positive strand viral 18kD cysteine rich protein Laminin_II PF06009.7 EWC46077.1 - 1.7 8.3 8.9 1.2 8.9 1.3 2.8 2 1 0 2 2 2 0 Laminin Domain II Shugoshin_N PF07558.6 EWC46077.1 - 4 7.2 7.3 9.4 6.0 0.2 3.9 3 1 1 4 4 4 0 Shugoshin N-terminal coiled-coil region CytochromB561_N PF09786.4 EWC46078.1 - 0.12 10.7 0.1 0.15 10.5 0.1 1.1 1 0 0 1 1 1 0 Cytochrome B561, N terminal Mito_fiss_reg PF05308.6 EWC46078.1 - 0.31 10.3 5.3 0.47 9.7 3.7 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator CAP_N PF01213.14 EWC46078.1 - 0.46 9.7 4.3 0.71 9.1 3.0 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Abhydrolase_4 PF08386.5 EWC46079.1 - 2.5e-16 59.4 0.0 4.5e-16 58.6 0.0 1.4 1 0 0 1 1 1 1 TAP-like protein Abhydrolase_1 PF00561.15 EWC46079.1 - 3.3e-10 39.8 0.0 3e-08 33.4 0.0 2.9 2 1 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 EWC46079.1 - 8.3e-09 35.6 0.0 1.3e-06 28.4 0.0 2.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EWC46079.1 - 0.0013 18.5 0.0 0.012 15.3 0.0 2.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Amidohydro_1 PF01979.15 EWC46080.1 - 2.6e-25 89.8 0.8 1e-24 87.8 0.6 1.9 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_5 PF13594.1 EWC46080.1 - 3e-15 55.7 0.1 9.8e-15 54.1 0.1 2.0 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_3 PF07969.6 EWC46080.1 - 2.1e-08 33.8 3.4 1.3e-06 27.8 0.0 3.3 2 1 0 3 3 3 1 Amidohydrolase family Amidohydro_4 PF13147.1 EWC46080.1 - 3.4e-07 30.5 1.4 0.003 17.6 0.9 2.9 2 1 0 2 2 2 2 Amidohydrolase UPF0122 PF04297.9 EWC46082.1 - 0.12 12.3 0.0 0.31 11.0 0.0 1.6 1 0 0 1 1 1 0 Putative helix-turn-helix protein, YlxM / p13 like F-box-like PF12937.2 EWC46083.1 - 2.2e-05 24.0 0.3 5.7e-05 22.7 0.2 1.7 1 0 0 1 1 1 1 F-box-like PRANC PF09372.5 EWC46083.1 - 0.016 15.1 0.1 0.038 13.9 0.1 1.6 1 0 0 1 1 1 0 PRANC domain UQ_con PF00179.21 EWC46085.1 - 1.3e-31 108.8 0.1 1.8e-31 108.4 0.1 1.2 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme Sas10_Utp3 PF04000.10 EWC46086.1 - 3.4e-10 39.9 1.2 4.9e-10 39.4 0.1 1.8 2 0 0 2 2 2 1 Sas10/Utp3/C1D family Vfa1 PF08432.5 EWC46086.1 - 4.9 7.1 13.9 1 9.3 7.0 1.7 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 BUD22 PF09073.5 EWC46086.1 - 5.8 5.8 21.6 0.0089 15.1 6.4 2.0 2 0 0 2 2 2 0 BUD22 CobT PF06213.7 EWC46086.1 - 7.7 5.5 17.5 13 4.7 12.1 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT NOA36 PF06524.7 EWC46086.1 - 8 5.6 11.8 14 4.8 8.2 1.3 1 0 0 1 1 1 0 NOA36 protein Rhodanese PF00581.15 EWC46087.1 - 9.1e-11 42.1 0.2 1.5e-09 38.1 0.1 2.2 1 1 0 1 1 1 1 Rhodanese-like domain FUSC PF04632.7 EWC46088.1 - 1.7 6.9 26.5 1.1 7.5 8.6 2.1 1 1 1 2 2 2 0 Fusaric acid resistance protein family zf-Di19 PF05605.7 EWC46089.1 - 0.00028 20.9 0.5 0.00028 20.9 0.3 2.3 2 0 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.21 EWC46089.1 - 0.00052 20.1 4.8 0.00085 19.5 0.7 3.2 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-met2 PF12907.2 EWC46089.1 - 0.0054 16.6 1.8 0.83 9.6 0.4 2.7 2 0 0 2 2 2 1 Zinc-binding zf-met PF12874.2 EWC46089.1 - 0.011 15.9 0.2 0.03 14.5 0.2 1.8 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.1 EWC46089.1 - 0.017 15.4 6.7 0.14 12.5 0.4 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 EWC46089.1 - 0.024 14.7 0.0 0.074 13.2 0.0 1.9 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.1 EWC46089.1 - 0.074 13.3 0.4 0.074 13.3 0.3 3.2 3 0 0 3 3 3 0 C2H2-type zinc-finger domain GAGA PF09237.6 EWC46089.1 - 0.17 11.4 5.1 0.61 9.7 0.0 3.2 4 0 0 4 4 4 0 GAGA factor zf-BED PF02892.10 EWC46089.1 - 0.19 11.5 2.5 0.72 9.6 0.1 2.5 2 0 0 2 2 2 0 BED zinc finger Zn_clus PF00172.13 EWC46089.1 - 0.52 10.2 12.1 0.017 15.0 3.5 2.1 2 0 0 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Cupin_8 PF13621.1 EWC46090.1 - 1.7e-34 119.4 0.0 2.7e-34 118.7 0.0 1.3 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.7 EWC46090.1 - 2.1e-07 30.4 0.0 1.1e-05 24.9 0.0 2.4 2 0 0 2 2 2 1 Cupin superfamily protein JmjC PF02373.17 EWC46090.1 - 0.00074 19.7 0.0 0.0089 16.2 0.0 2.3 2 0 0 2 2 2 1 JmjC domain, hydroxylase Cupin_2 PF07883.6 EWC46090.1 - 0.01 15.3 0.0 0.035 13.6 0.0 1.9 1 0 0 1 1 1 0 Cupin domain PA28_beta PF02252.13 EWC46090.1 - 0.17 11.3 0.0 0.29 10.5 0.0 1.3 1 0 0 1 1 1 0 Proteasome activator pa28 beta subunit Thiolase_N PF00108.18 EWC46091.1 - 4.6e-92 307.7 0.7 7.1e-92 307.1 0.5 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.13 EWC46091.1 - 7e-39 132.0 1.7 1.1e-38 131.4 0.2 2.0 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.21 EWC46091.1 - 0.0018 17.7 1.7 0.052 13.0 0.5 2.6 1 1 1 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain DegS PF05384.6 EWC46091.1 - 0.074 12.2 0.0 0.13 11.4 0.0 1.3 1 0 0 1 1 1 0 Sensor protein DegS Glyco_hydro_16 PF00722.16 EWC46093.1 - 1.7e-11 43.7 0.1 2.6e-11 43.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 F-box-like PF12937.2 EWC46098.1 - 5.8e-05 22.7 0.0 0.00024 20.7 0.0 2.1 1 1 0 1 1 1 1 F-box-like nec1 PF10379.4 EWC46098.1 - 0.11 11.7 0.0 0.23 10.7 0.0 1.4 1 0 0 1 1 1 0 Virulence protein nec1 F-box PF00646.28 EWC46098.1 - 0.13 11.9 1.3 2.8 7.7 0.1 3.1 3 0 0 3 3 3 0 F-box domain UQ_con PF00179.21 EWC46099.1 - 1.2e-51 173.8 0.0 1.3e-51 173.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 EWC46099.1 - 3.3e-06 26.9 0.0 3.7e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 EWC46099.1 - 0.078 12.8 0.2 0.1 12.5 0.1 1.5 1 1 0 1 1 1 0 RWD domain NHL PF01436.16 EWC46100.1 - 0.088 12.8 0.5 3.8 7.6 0.0 3.6 4 0 0 4 4 4 0 NHL repeat AMP-binding PF00501.23 EWC46101.1 - 7.4e-77 258.4 0.0 9.1e-77 258.1 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 EWC46101.1 - 2.2e-15 57.3 0.3 1e-14 55.1 0.0 2.3 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain DUF2637 PF10935.3 EWC46102.1 - 0.058 13.3 0.7 0.098 12.5 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2637) TPR_2 PF07719.12 EWC46102.1 - 0.18 11.7 0.8 0.64 10.0 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF2408 PF10303.4 EWC46103.1 - 0.0051 16.9 0.5 6.5 6.8 0.0 3.3 4 0 0 4 4 4 2 Protein of unknown function (DUF2408) Ribosomal_60s PF00428.14 EWC46103.1 - 0.051 13.9 7.4 0.16 12.3 5.1 1.8 1 0 0 1 1 1 0 60s Acidic ribosomal protein TFIIA PF03153.8 EWC46103.1 - 0.27 11.0 7.0 0.46 10.3 4.8 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit HsdM_N PF12161.3 EWC46103.1 - 0.45 10.9 6.7 27 5.1 0.1 3.4 3 1 0 3 3 3 0 HsdM N-terminal domain Myc_N PF01056.13 EWC46103.1 - 2.2 7.3 9.1 4.7 6.2 6.3 1.5 1 0 0 1 1 1 0 Myc amino-terminal region Nucleoplasmin PF03066.10 EWC46103.1 - 3.5 7.1 15.8 3.2 7.2 7.1 2.4 2 0 0 2 2 2 0 Nucleoplasmin Ribonucleas_3_3 PF14622.1 EWC46105.1 - 0.00041 20.3 0.0 0.00062 19.7 0.0 1.2 1 0 0 1 1 1 1 Ribonuclease-III-like EMP70 PF02990.11 EWC46106.1 - 3.4e-201 669.2 6.7 4.5e-201 668.8 4.7 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 DUF4229 PF14012.1 EWC46106.1 - 0.041 13.7 0.1 0.041 13.7 0.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF4229) CHAT PF12770.2 EWC46107.1 - 2.7e-35 121.9 0.4 4.6e-35 121.1 0.2 1.4 1 0 0 1 1 1 1 CHAT domain TPR_11 PF13414.1 EWC46107.1 - 2.1e-09 36.8 16.7 0.053 13.1 0.7 7.4 4 3 3 7 7 7 5 TPR repeat TPR_12 PF13424.1 EWC46107.1 - 1.9e-05 24.5 13.5 0.35 10.8 0.9 6.5 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.1 EWC46107.1 - 0.00049 20.4 3.5 0.7 10.6 0.0 5.8 5 0 0 5 5 5 1 Tetratricopeptide repeat FtsA PF14450.1 EWC46107.1 - 0.027 14.3 0.0 1.2 9.0 0.0 3.0 2 1 0 3 3 3 0 Cell division protein FtsA Arrestin_N PF00339.24 EWC46108.1 - 4.3e-08 33.1 0.0 6.5e-07 29.2 0.0 2.6 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain zf-TFIIIC PF12660.2 EWC46109.1 - 1.9e-20 72.5 0.1 6.7e-20 70.8 0.0 1.9 2 0 0 2 2 2 1 Putative zinc-finger of transcription factor IIIC complex TFIIIC_delta PF12657.2 EWC46109.1 - 8.6e-07 28.8 0.0 1.4e-05 24.8 0.0 2.4 1 1 0 1 1 1 1 Transcription factor IIIC subunit delta N-term MPLKIP PF15502.1 EWC46110.1 - 0.096 13.3 26.3 0.22 12.1 18.2 1.7 1 1 0 1 1 1 0 M-phase-specific PLK1-interacting protein KxDL PF10241.4 EWC46111.1 - 3.8e-27 94.0 0.6 5.1e-27 93.5 0.4 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein RNA_capsid PF03035.9 EWC46111.1 - 0.23 11.2 5.0 0.056 13.2 1.3 1.5 2 0 0 2 2 2 0 Calicivirus putative RNA polymerase/capsid protein Mito_carr PF00153.22 EWC46112.1 - 0.003 17.2 0.3 0.043 13.5 0.1 2.4 2 0 0 2 2 2 1 Mitochondrial carrier protein Allantoicase PF03561.10 EWC46113.1 - 8.4e-98 324.0 0.0 1.7e-52 176.8 0.0 3.0 2 1 1 3 3 3 3 Allantoicase repeat F5_F8_type_C PF00754.20 EWC46113.1 - 0.001 18.9 0.1 0.015 15.1 0.0 2.4 2 0 0 2 2 2 1 F5/8 type C domain EF-hand_1 PF00036.27 EWC46115.1 - 1.6e-24 83.2 7.4 2.4e-07 29.5 0.1 4.8 5 0 0 5 5 5 4 EF hand EF-hand_6 PF13405.1 EWC46115.1 - 4.4e-23 79.0 2.6 3.2e-06 26.5 0.1 5.1 4 1 1 5 5 5 4 EF-hand domain EF-hand_7 PF13499.1 EWC46115.1 - 1.1e-21 76.6 2.8 3.3e-13 49.5 0.1 3.1 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 EWC46115.1 - 5.8e-16 57.0 8.1 6e-05 22.1 0.3 4.8 5 0 0 5 5 5 4 EF hand EF-hand_8 PF13833.1 EWC46115.1 - 3.6e-12 45.7 8.7 1.6e-05 24.3 0.4 4.1 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_4 PF12763.2 EWC46115.1 - 1.8e-06 27.5 5.2 0.039 13.6 0.1 3.8 1 1 2 4 4 4 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.1 EWC46115.1 - 0.0015 18.4 0.3 0.05 13.5 0.0 2.9 2 1 1 3 3 3 1 EF-hand domain SPARC_Ca_bdg PF10591.4 EWC46115.1 - 0.0025 17.8 1.9 0.85 9.6 0.1 3.1 2 2 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region DUF1679 PF07914.6 EWC46115.1 - 0.021 13.4 0.5 3.1 6.3 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1679) EF-hand_10 PF14788.1 EWC46115.1 - 0.048 13.3 2.9 8 6.2 0.0 4.0 3 1 0 3 3 3 0 EF hand EF-hand_2 PF09068.6 EWC46115.1 - 0.08 13.0 0.0 3.7 7.6 0.0 2.6 2 1 0 2 2 2 0 EF hand HATPase_c PF02518.21 EWC46116.1 - 1.6e-24 85.7 0.0 3.1e-24 84.8 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_9 PF13426.1 EWC46116.1 - 7.9e-23 80.8 0.0 4.7e-10 39.7 0.0 2.9 2 0 0 2 2 2 2 PAS domain PAS_3 PF08447.6 EWC46116.1 - 3e-22 78.5 0.7 1.4e-11 44.3 0.1 3.6 3 0 0 3 3 3 3 PAS fold Response_reg PF00072.19 EWC46116.1 - 6.7e-20 71.1 0.0 2.3e-18 66.2 0.0 2.5 2 0 0 2 2 2 1 Response regulator receiver domain PAS PF00989.19 EWC46116.1 - 8.2e-17 61.0 0.0 4.4e-09 36.1 0.0 3.6 2 1 0 2 2 2 2 PAS fold HisKA PF00512.20 EWC46116.1 - 9e-17 60.8 0.0 2.6e-16 59.3 0.0 1.9 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_4 PF08448.5 EWC46116.1 - 3.6e-10 39.8 0.4 6e-07 29.4 0.1 4.0 3 0 0 3 3 3 1 PAS fold Mo25 PF08569.6 EWC46117.1 - 3.6e-114 381.2 1.2 3.3e-113 378.1 0.8 1.9 1 1 0 1 1 1 1 Mo25-like HEAT_2 PF13646.1 EWC46117.1 - 0.0011 19.2 0.1 0.0055 16.9 0.0 2.1 2 0 0 2 2 2 1 HEAT repeats RepA_N PF06970.6 EWC46117.1 - 0.061 13.1 0.2 0.14 12.0 0.2 1.6 1 0 0 1 1 1 0 Replication initiator protein A (RepA) N-terminus AAA PF00004.24 EWC46118.1 - 2.1e-52 176.7 0.0 8.9e-40 135.9 0.0 2.3 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 EWC46118.1 - 8.9e-09 35.5 0.3 0.00045 20.3 0.1 3.8 2 2 0 2 2 2 2 AAA domain CDC48_N PF02359.13 EWC46118.1 - 9.6e-09 35.0 0.1 3.6e-08 33.2 0.0 2.1 2 0 0 2 2 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_2 PF07724.9 EWC46118.1 - 4e-08 33.3 0.0 4.7e-06 26.6 0.0 3.2 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) CDC48_2 PF02933.12 EWC46118.1 - 4.1e-08 32.7 0.3 4.6e-06 26.1 0.1 2.6 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), domain 2 AAA_14 PF13173.1 EWC46118.1 - 5.2e-08 32.8 0.0 0.0074 16.1 0.0 2.8 3 0 0 3 3 3 2 AAA domain AAA_19 PF13245.1 EWC46118.1 - 7.2e-08 32.0 0.4 0.019 14.6 0.0 3.9 3 0 0 3 3 3 2 Part of AAA domain TIP49 PF06068.8 EWC46118.1 - 7.7e-08 31.4 0.0 0.0044 15.8 0.0 2.2 2 0 0 2 2 2 2 TIP49 C-terminus AAA_17 PF13207.1 EWC46118.1 - 1.7e-07 32.1 0.1 0.002 18.9 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.1 EWC46118.1 - 2.9e-07 30.6 0.0 0.0047 16.9 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain RuvB_N PF05496.7 EWC46118.1 - 5.9e-07 28.7 0.0 0.025 13.6 0.0 2.8 2 0 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_33 PF13671.1 EWC46118.1 - 1.8e-06 27.8 0.0 0.076 12.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.1 EWC46118.1 - 4.1e-06 27.1 0.3 0.0032 17.7 0.0 3.0 3 0 0 3 3 2 1 AAA domain AAA_5 PF07728.9 EWC46118.1 - 4.6e-06 26.4 0.0 0.0012 18.6 0.0 3.0 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.16 EWC46118.1 - 1e-05 24.8 0.3 0.005 16.0 0.0 2.3 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_28 PF13521.1 EWC46118.1 - 1.6e-05 24.9 0.0 0.25 11.2 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.1 EWC46118.1 - 4.6e-05 22.8 2.7 0.76 9.1 0.0 4.1 3 2 2 5 5 4 2 AAA domain RNA_helicase PF00910.17 EWC46118.1 - 5.1e-05 23.3 0.0 0.045 13.9 0.0 2.6 2 0 0 2 2 2 1 RNA helicase Zeta_toxin PF06414.7 EWC46118.1 - 0.00014 21.0 0.0 0.43 9.6 0.0 2.4 2 0 0 2 2 2 2 Zeta toxin IstB_IS21 PF01695.12 EWC46118.1 - 0.00022 20.7 0.7 0.04 13.3 0.0 2.8 3 0 0 3 3 3 1 IstB-like ATP binding protein Arch_ATPase PF01637.13 EWC46118.1 - 0.00023 20.9 1.7 5.5 6.6 0.1 4.0 2 2 2 4 4 4 0 Archaeal ATPase KaiC PF06745.8 EWC46118.1 - 0.00077 18.6 0.2 0.021 13.9 0.1 2.4 2 0 0 2 2 2 1 KaiC KTI12 PF08433.5 EWC46118.1 - 0.00097 18.4 0.2 0.53 9.4 0.0 2.6 2 0 0 2 2 2 1 Chromatin associated protein KTI12 NACHT PF05729.7 EWC46118.1 - 0.0012 18.5 0.3 5.1 6.7 0.0 3.6 3 1 1 4 4 4 0 NACHT domain Parvo_NS1 PF01057.12 EWC46118.1 - 0.0021 17.0 0.0 0.4 9.5 0.0 2.2 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 Sigma54_activat PF00158.21 EWC46118.1 - 0.0056 16.1 0.0 0.53 9.7 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_24 PF13479.1 EWC46118.1 - 0.0058 16.2 0.3 0.12 11.9 0.1 2.4 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.22 EWC46118.1 - 0.011 16.0 0.3 0.046 14.0 0.1 2.1 2 0 0 2 2 2 0 ABC transporter PhoH PF02562.11 EWC46118.1 - 0.011 14.9 0.0 1.6 7.9 0.0 2.4 2 0 0 2 2 2 0 PhoH-like protein UPF0079 PF02367.12 EWC46118.1 - 0.015 14.9 0.1 0.72 9.4 0.0 2.3 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 NB-ARC PF00931.17 EWC46118.1 - 0.017 14.0 0.1 1.3 7.8 0.1 2.6 2 0 0 2 2 2 0 NB-ARC domain AAA_11 PF13086.1 EWC46118.1 - 0.021 14.4 0.0 1.4 8.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.4 EWC46118.1 - 0.024 13.6 0.1 0.14 11.0 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_3 PF07726.6 EWC46118.1 - 0.037 13.6 0.0 0.32 10.6 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) CPT PF07931.7 EWC46118.1 - 0.06 12.9 0.1 1 8.9 0.0 2.3 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein IPT PF01745.11 EWC46118.1 - 0.13 11.3 0.1 1.6 7.8 0.0 2.3 2 0 0 2 2 2 0 Isopentenyl transferase RasGEF PF00617.14 EWC46119.1 - 7e-42 143.2 0.0 1.2e-41 142.5 0.0 1.3 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.15 EWC46119.1 - 8.9e-14 51.4 0.0 1.8e-13 50.5 0.0 1.4 1 0 0 1 1 1 1 RasGEF N-terminal motif DUF2457 PF10446.4 EWC46119.1 - 0.0024 16.6 18.3 0.0024 16.6 12.7 2.5 3 0 0 3 3 1 1 Protein of unknown function (DUF2457) Nop14 PF04147.7 EWC46119.1 - 0.0053 14.7 12.5 0.0081 14.1 8.7 1.2 1 0 0 1 1 1 1 Nop14-like family CDC45 PF02724.9 EWC46119.1 - 0.023 12.7 9.0 0.036 12.1 6.3 1.2 1 0 0 1 1 1 0 CDC45-like protein BUD22 PF09073.5 EWC46119.1 - 0.15 11.1 15.7 0.26 10.2 10.9 1.3 1 0 0 1 1 1 0 BUD22 Daxx PF03344.10 EWC46119.1 - 0.51 8.7 17.1 1.2 7.4 11.9 1.5 1 0 0 1 1 1 0 Daxx Family SDA1 PF05285.7 EWC46119.1 - 0.55 9.4 13.6 0.97 8.6 9.4 1.3 1 0 0 1 1 1 0 SDA1 Sigma70_ner PF04546.8 EWC46119.1 - 0.61 9.6 13.0 1.2 8.6 9.0 1.4 1 0 0 1 1 1 0 Sigma-70, non-essential region PPP4R2 PF09184.6 EWC46119.1 - 2.1 7.8 13.5 5.1 6.5 9.4 1.6 1 0 0 1 1 1 0 PPP4R2 Herpes_LMP1 PF05297.6 EWC46119.1 - 3.4 6.5 10.3 8.9 5.1 7.1 1.7 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) 5_nucleotid_C PF02872.13 EWC46120.1 - 2.6e-33 115.2 0.0 4e-33 114.5 0.0 1.3 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.23 EWC46120.1 - 3.8e-07 29.7 0.0 6e-07 29.0 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase CAF-1_p150 PF11600.3 EWC46120.1 - 0.84 8.9 3.7 1.3 8.3 2.6 1.2 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Methyltransf_31 PF13847.1 EWC46121.1 - 1.5e-12 47.3 0.0 3.3e-12 46.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 EWC46121.1 - 1.6e-12 47.1 0.0 2.8e-12 46.3 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.2 EWC46121.1 - 1.1e-10 42.0 0.0 3.6e-10 40.4 0.0 1.8 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EWC46121.1 - 2.7e-10 40.6 0.0 1e-09 38.7 0.0 2.0 2 0 0 2 2 1 1 Methyltransferase domain MTS PF05175.9 EWC46121.1 - 5.3e-08 32.4 0.2 1.2e-07 31.3 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_26 PF13659.1 EWC46121.1 - 6.8e-08 32.5 0.0 1.4e-07 31.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EWC46121.1 - 5e-06 26.3 0.0 9.1e-06 25.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EWC46121.1 - 1e-05 25.8 0.1 3.1e-05 24.2 0.0 1.9 2 0 0 2 2 1 1 Methyltransferase domain Met_10 PF02475.11 EWC46121.1 - 4.8e-05 23.0 0.1 4.8e-05 23.0 0.1 1.8 3 0 0 3 3 2 1 Met-10+ like-protein Methyltransf_12 PF08242.7 EWC46121.1 - 5.2e-05 23.6 0.0 0.00022 21.6 0.0 2.1 2 0 0 2 2 1 1 Methyltransferase domain CMAS PF02353.15 EWC46121.1 - 6.1e-05 22.2 0.0 9.6e-05 21.5 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_16 PF10294.4 EWC46121.1 - 0.00012 21.5 0.1 0.00024 20.6 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase PRMT5 PF05185.11 EWC46121.1 - 0.00019 20.5 0.1 0.00032 19.7 0.1 1.3 1 1 0 1 1 1 1 PRMT5 arginine-N-methyltransferase FtsJ PF01728.14 EWC46121.1 - 0.00053 20.0 0.1 0.0017 18.3 0.0 1.8 2 0 0 2 2 2 1 FtsJ-like methyltransferase Ubie_methyltran PF01209.13 EWC46121.1 - 0.001 18.2 0.1 0.0019 17.3 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_9 PF08003.6 EWC46121.1 - 0.0011 17.7 0.0 0.0021 16.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) PCMT PF01135.14 EWC46121.1 - 0.0018 17.8 0.0 0.0032 17.0 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TehB PF03848.9 EWC46121.1 - 0.0036 16.5 0.1 0.0056 15.8 0.1 1.3 1 0 0 1 1 1 1 Tellurite resistance protein TehB Cons_hypoth95 PF03602.10 EWC46121.1 - 0.0066 15.8 0.3 0.047 13.0 0.0 2.2 2 0 0 2 2 2 1 Conserved hypothetical protein 95 Surfac_D-trimer PF09006.6 EWC46121.1 - 0.0092 15.6 0.1 0.024 14.3 0.0 1.7 1 0 0 1 1 1 1 Lung surfactant protein D coiled-coil trimerisation UPF0020 PF01170.13 EWC46121.1 - 0.032 13.8 0.1 0.066 12.7 0.1 1.4 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 tRNA_U5-meth_tr PF05958.6 EWC46121.1 - 0.055 12.1 0.0 0.095 11.3 0.0 1.3 1 0 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase Methyltransf_24 PF13578.1 EWC46121.1 - 0.092 13.5 0.0 0.26 12.1 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_32 PF13679.1 EWC46121.1 - 0.11 12.1 0.0 0.22 11.2 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Peptidase_C13 PF01650.13 EWC46122.1 - 1.3e-43 149.1 0.1 1.5e-43 148.9 0.1 1.1 1 0 0 1 1 1 1 Peptidase C13 family Nif11 PF07862.6 EWC46122.1 - 0.0081 16.0 0.0 0.024 14.5 0.0 1.8 1 0 0 1 1 1 1 Nitrogen fixation protein of unknown function tRNA-synt_1 PF00133.17 EWC46123.1 - 1.6e-223 743.0 0.0 2.9e-223 742.2 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.8 EWC46123.1 - 3.3e-25 88.6 0.0 8.9e-25 87.2 0.0 1.7 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.6 EWC46123.1 - 1.2e-15 57.1 0.7 4.3e-06 25.6 0.1 4.1 3 1 0 3 3 3 3 tRNA synthetases class I (M) Memo PF01875.12 EWC46123.1 - 0.031 13.1 0.0 0.062 12.1 0.0 1.4 1 0 0 1 1 1 0 Memo-like protein tRNA-synt_1e PF01406.14 EWC46123.1 - 0.057 12.5 0.0 0.33 10.0 0.0 2.3 3 0 0 3 3 3 0 tRNA synthetases class I (C) catalytic domain SH3_9 PF14604.1 EWC46124.1 - 3.1e-10 39.4 0.0 4.9e-10 38.8 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 EWC46124.1 - 4.9e-07 29.0 0.0 8.5e-07 28.2 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.12 EWC46124.1 - 0.00016 21.0 0.0 0.00029 20.2 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain EphA2_TM PF14575.1 EWC46124.1 - 0.013 15.8 0.0 0.024 15.0 0.0 1.3 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DAP10 PF07213.6 EWC46124.1 - 0.018 14.7 0.0 0.038 13.7 0.0 1.5 1 0 0 1 1 1 0 DAP10 membrane protein Herpes_gE PF02480.11 EWC46124.1 - 0.038 12.2 0.0 0.066 11.4 0.0 1.3 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E muHD PF10291.4 EWC46125.1 - 6.9e-62 208.9 0.0 9.7e-62 208.4 0.0 1.2 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain FCH PF00611.18 EWC46125.1 - 2.9e-12 46.5 0.0 7.1e-12 45.3 0.0 1.7 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain BAR PF03114.13 EWC46125.1 - 0.0043 16.6 1.0 0.0066 15.9 0.7 1.2 1 0 0 1 1 1 1 BAR domain DUF1227 PF06777.6 EWC46126.1 - 1.6e-61 206.2 0.4 3.3e-61 205.2 0.3 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1227) DEAD_2 PF06733.10 EWC46126.1 - 1.3e-51 174.5 0.4 2.1e-51 173.7 0.2 1.4 1 0 0 1 1 1 1 DEAD_2 Helicase_C_2 PF13307.1 EWC46126.1 - 1.1e-43 149.1 0.0 2.2e-43 148.0 0.0 1.6 1 0 0 1 1 1 1 Helicase C-terminal domain SNF2_N PF00176.18 EWC46126.1 - 0.0026 16.6 0.0 0.012 14.4 0.0 2.0 1 1 0 1 1 1 1 SNF2 family N-terminal domain DEAD PF00270.24 EWC46126.1 - 0.0086 15.5 0.0 1.2 8.6 0.0 2.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.10 EWC46126.1 - 0.071 12.9 0.1 0.57 9.9 0.1 2.1 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit YtxC PF08812.6 EWC46126.1 - 0.11 11.9 0.7 0.31 10.4 0.0 2.1 2 0 0 2 2 2 0 YtxC-like family Remorin_C PF03763.8 EWC46126.1 - 0.52 9.8 4.3 2 7.9 0.3 2.3 2 0 0 2 2 2 0 Remorin, C-terminal region zf-RING_2 PF13639.1 EWC46127.1 - 3.6e-07 29.9 6.8 6.9e-07 29.0 4.2 1.9 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.2 EWC46127.1 - 7.7e-07 29.1 1.3 1.9e-06 27.9 0.9 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger zf-Apc11 PF12861.2 EWC46127.1 - 1.2e-05 25.0 1.4 2.8e-05 23.8 0.9 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger FANCL_C PF11793.3 EWC46127.1 - 5.8e-05 22.9 3.5 0.00019 21.3 2.4 1.9 1 0 0 1 1 1 1 FANCL C-terminal domain RINGv PF12906.2 EWC46127.1 - 0.0045 17.0 6.4 0.0086 16.0 4.4 1.5 1 0 0 1 1 1 1 RING-variant domain zf-C3HC4 PF00097.20 EWC46127.1 - 0.0085 15.7 5.9 0.016 14.8 4.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) HEAT_EZ PF13513.1 EWC46127.1 - 0.019 15.4 0.2 5.1 7.7 0.0 4.5 3 0 0 3 3 2 0 HEAT-like repeat zf-RING-like PF08746.6 EWC46127.1 - 0.053 13.5 4.4 0.13 12.3 3.1 1.7 1 0 0 1 1 1 0 RING-like domain zf-C3HC4_2 PF13923.1 EWC46127.1 - 0.17 11.9 7.3 0.33 11.0 5.1 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) C1_1 PF00130.17 EWC46127.1 - 0.9 9.3 6.1 0.21 11.3 1.3 2.2 2 1 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING_4 PF14570.1 EWC46127.1 - 1.1 8.9 5.0 30 4.2 2.2 3.0 2 1 0 2 2 2 0 RING/Ubox like zinc-binding domain PHD PF00628.24 EWC46127.1 - 1.1 8.9 4.7 2.6 7.8 3.3 1.7 1 0 0 1 1 1 0 PHD-finger zf-C3HC4_3 PF13920.1 EWC46127.1 - 1.9 8.2 5.0 4.1 7.1 3.5 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Clat_adaptor_s PF01217.15 EWC46128.1 - 1.2e-56 190.3 1.8 1.4e-56 190.1 1.2 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain DUF2422 PF10337.4 EWC46129.1 - 1.1e-29 103.5 17.2 1e-20 74.0 0.0 4.4 3 1 1 4 4 4 3 Protein of unknown function (DUF2422) FUSC_2 PF13515.1 EWC46129.1 - 1.6e-13 50.6 14.5 1.6e-13 50.6 10.0 2.7 2 0 0 2 2 2 1 Fusaric acid resistance protein-like ALMT PF11744.3 EWC46129.1 - 1.1e-05 24.3 19.0 0.0012 17.6 8.6 2.8 3 1 0 3 3 3 2 Aluminium activated malate transporter DUF2421 PF10334.4 EWC46129.1 - 0.0065 16.1 0.4 0.013 15.1 0.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2421) DUF939 PF06081.6 EWC46129.1 - 0.052 13.4 17.5 0.014 15.2 4.5 3.0 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF939) CCDC32 PF14989.1 EWC46129.1 - 0.1 12.4 5.0 0.16 11.7 0.0 3.0 3 0 0 3 3 3 0 Coiled-coil domain containing 32 Ist1 PF03398.9 EWC46130.1 - 5.9e-61 204.6 6.2 7.4e-61 204.3 4.3 1.1 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway Mmp37 PF09139.6 EWC46131.1 - 3.1e-112 374.8 0.0 4.2e-112 374.4 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial matrix Mmp37 SUN PF03856.8 EWC46132.1 - 1.5e-74 250.4 7.5 1.5e-74 250.4 5.2 1.7 2 0 0 2 2 2 1 Beta-glucosidase (SUN family) AvrE PF11725.3 EWC46132.1 - 0.55 7.1 6.5 0.7 6.8 4.5 1.0 1 0 0 1 1 1 0 Pathogenicity factor OPT PF03169.10 EWC46133.1 - 9.9e-144 480.1 17.0 1.1e-143 479.9 11.8 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein RasGAP PF00616.14 EWC46134.1 - 2.6e-45 154.5 0.2 2.6e-45 154.5 0.2 2.6 3 0 0 3 3 3 1 GTPase-activator protein for Ras-like GTPase CRAL_TRIO_2 PF13716.1 EWC46134.1 - 2.4e-07 30.7 0.1 1.4e-06 28.2 0.0 2.4 2 0 0 2 2 2 1 Divergent CRAL/TRIO domain Iron_permease PF04120.7 EWC46135.1 - 0.13 11.8 0.1 0.13 11.8 0.1 2.4 1 1 2 3 3 3 0 Low affinity iron permease XRN_N PF03159.13 EWC46136.1 - 3e-109 363.9 0.0 6.3e-109 362.9 0.0 1.5 2 0 0 2 2 2 1 XRN 5'-3' exonuclease N-terminus zf-CCHC PF00098.18 EWC46136.1 - 0.0099 15.7 2.0 0.017 15.0 1.4 1.4 1 0 0 1 1 1 1 Zinc knuckle Uso1_p115_head PF04869.9 EWC46137.1 - 2.6e-95 318.7 0.1 9.8e-95 316.8 0.0 2.1 1 0 0 1 1 1 1 Uso1 / p115 like vesicle tethering protein, head region Uso1_p115_C PF04871.8 EWC46137.1 - 0.0061 16.4 33.7 0.0061 16.4 23.3 3.6 1 1 1 3 3 3 2 Uso1 / p115 like vesicle tethering protein, C terminal region Arm PF00514.18 EWC46137.1 - 0.012 15.4 0.3 2 8.3 0.0 4.2 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat DHQ_synthase PF01761.15 EWC46138.1 - 3.9e-65 219.3 0.0 4.9e-65 219.0 0.0 1.1 1 0 0 1 1 1 1 3-dehydroquinate synthase Fe-ADH_2 PF13685.1 EWC46138.1 - 1.3e-08 34.4 0.0 1.8e-08 34.0 0.0 1.2 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase EPSP_synthase PF00275.15 EWC46139.1 - 6.7e-130 433.2 0.0 9.4e-130 432.7 0.0 1.1 1 0 0 1 1 1 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) DHquinase_I PF01487.10 EWC46139.1 - 5.5e-60 202.8 0.0 1e-59 201.9 0.0 1.4 1 0 0 1 1 1 1 Type I 3-dehydroquinase SKI PF01202.17 EWC46139.1 - 1.3e-34 119.3 0.0 2.2e-34 118.6 0.0 1.4 1 0 0 1 1 1 1 Shikimate kinase Shikimate_dh_N PF08501.6 EWC46139.1 - 1.8e-24 85.6 0.0 4.9e-24 84.1 0.0 1.8 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain Shikimate_DH PF01488.15 EWC46139.1 - 1.9e-11 44.2 0.1 5.3e-11 42.7 0.0 1.7 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase DHQ_synthase PF01761.15 EWC46139.1 - 4.3e-05 22.5 0.0 0.00022 20.2 0.0 2.1 2 0 0 2 2 2 1 3-dehydroquinate synthase AAA_17 PF13207.1 EWC46139.1 - 0.0011 19.7 0.0 0.0034 18.1 0.0 1.9 1 0 0 1 1 1 1 AAA domain zf-C2H2 PF00096.21 EWC46140.1 - 7e-12 44.9 11.0 0.0025 18.0 0.3 3.9 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EWC46140.1 - 1.1e-05 25.4 13.2 0.26 11.7 1.1 4.0 3 0 0 3 3 3 3 C2H2-type zinc finger zf-Di19 PF05605.7 EWC46140.1 - 0.013 15.6 2.8 1.5 8.9 0.3 2.6 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_5 PF13909.1 EWC46140.1 - 0.12 12.6 5.5 5.5 7.4 0.9 3.7 3 0 0 3 3 3 0 C2H2-type zinc-finger domain RNA_pol_Rpb1_5 PF04998.12 EWC46141.1 - 2.3e-89 299.3 0.0 4e-89 298.5 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.15 EWC46141.1 - 2.9e-63 212.7 0.4 5.6e-63 211.8 0.3 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.13 EWC46141.1 - 4.6e-34 117.4 0.0 1.2e-33 116.0 0.0 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_1 PF04997.7 EWC46141.1 - 4.5e-29 101.7 0.4 1.6e-23 83.5 0.0 2.7 2 1 0 2 2 2 2 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_4 PF05000.12 EWC46141.1 - 1.5e-19 69.6 0.1 8.6e-19 67.2 0.0 2.4 3 0 0 3 3 3 1 RNA polymerase Rpb1, domain 4 BUD22 PF09073.5 EWC46141.1 - 1.4 7.9 20.2 2.6 7.0 14.0 1.4 1 0 0 1 1 1 0 BUD22 PPP4R2 PF09184.6 EWC46141.1 - 2.5 7.5 17.1 4.6 6.6 11.9 1.4 1 0 0 1 1 1 0 PPP4R2 PRP3 PF08572.5 EWC46142.1 - 5.1e-66 222.2 2.5 5.1e-66 222.2 1.7 1.6 2 0 0 2 2 2 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.7 EWC46142.1 - 9.5e-40 135.2 0.7 9.5e-40 135.2 0.5 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1115) Glyco_transf_22 PF03901.12 EWC46143.1 - 3.6e-55 187.6 15.2 4.6e-55 187.3 10.5 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family YbjM PF11045.3 EWC46143.1 - 0.077 12.7 8.5 0.24 11.1 5.6 2.1 1 1 1 2 2 2 0 Putative inner membrane protein of Enterobacteriaceae DUF1049 PF06305.6 EWC46143.1 - 8.7 5.9 12.5 9.5 5.7 1.0 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1049) Gar1 PF04410.9 EWC46144.1 - 5.4e-43 146.1 0.1 2.1e-42 144.2 0.1 2.1 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region TMA7 PF09072.5 EWC46144.1 - 6.5 7.2 7.9 0.18 12.2 0.7 1.9 2 0 0 2 2 2 0 Translation machinery associated TMA7 Histone PF00125.19 EWC46145.1 - 3.1e-31 107.3 0.4 4.9e-31 106.6 0.3 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.1 EWC46145.1 - 2.4e-06 27.6 0.0 3.7e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 Kinetochore component CENP-S CBFD_NFYB_HMF PF00808.18 EWC46145.1 - 0.005 16.8 0.4 0.0082 16.1 0.0 1.5 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.8 EWC46145.1 - 0.051 13.3 0.1 0.086 12.5 0.0 1.4 1 0 0 1 1 1 0 Bromodomain associated Histone PF00125.19 EWC46146.1 - 1.6e-15 56.9 0.1 1.9e-15 56.6 0.1 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TAF PF02969.12 EWC46146.1 - 0.0001 22.1 0.1 0.00015 21.6 0.1 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-S PF15630.1 EWC46146.1 - 0.00012 22.1 0.1 0.00018 21.6 0.1 1.4 1 1 0 1 1 1 1 Kinetochore component CENP-S CBFD_NFYB_HMF PF00808.18 EWC46146.1 - 0.00017 21.5 0.1 0.0003 20.7 0.0 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.8 EWC46146.1 - 0.018 14.7 0.0 0.021 14.5 0.0 1.2 1 0 0 1 1 1 0 Bromodomain associated CENP-T PF15511.1 EWC46146.1 - 0.022 14.0 0.0 0.022 13.9 0.0 1.0 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T Thioredoxin_7 PF13899.1 EWC46147.1 - 1.8e-13 50.2 0.0 4e-13 49.1 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like UBA_4 PF14555.1 EWC46147.1 - 5.9e-12 44.9 0.0 1.2e-11 43.9 0.0 1.6 1 0 0 1 1 1 1 UBA-like domain UBX PF00789.15 EWC46147.1 - 2.3e-10 40.4 0.0 4.5e-10 39.4 0.0 1.5 1 0 0 1 1 1 1 UBX domain UIM PF02809.15 EWC46147.1 - 0.061 12.9 0.2 0.061 12.9 0.1 3.4 3 0 0 3 3 3 0 Ubiquitin interaction motif Zip PF02535.17 EWC46148.1 - 8e-50 169.6 2.8 9.3e-50 169.4 2.0 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter HAD_2 PF13419.1 EWC46149.1 - 6.3e-15 55.8 0.0 1.1e-14 55.0 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Methyltransf_31 PF13847.1 EWC46149.1 - 1.4e-11 44.1 0.0 2.5e-11 43.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 EWC46149.1 - 7e-11 41.7 0.0 1.1e-10 41.1 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Hydrolase PF00702.21 EWC46149.1 - 2.2e-10 41.3 0.1 6.3e-09 36.5 0.1 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 EWC46149.1 - 4.8e-09 35.8 0.0 1e-08 34.7 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Methyltransf_18 PF12847.2 EWC46149.1 - 5.5e-08 33.3 0.0 1.3e-07 32.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EWC46149.1 - 6.1e-08 33.0 0.0 1.6e-07 31.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EWC46149.1 - 1.3e-06 28.3 0.0 6.1e-06 26.2 0.0 2.1 1 1 1 2 2 2 1 Methyltransferase domain PRMT5 PF05185.11 EWC46149.1 - 1.4e-06 27.5 0.0 2.6e-06 26.6 0.0 1.4 1 1 0 1 1 1 1 PRMT5 arginine-N-methyltransferase HAD PF12710.2 EWC46149.1 - 1.8e-05 25.0 0.0 3.7e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Methyltransf_23 PF13489.1 EWC46149.1 - 0.00018 21.3 0.0 0.002 17.8 0.0 2.5 3 0 0 3 3 3 1 Methyltransferase domain MTS PF05175.9 EWC46149.1 - 0.00039 19.8 0.1 0.00072 18.9 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.1 EWC46149.1 - 0.00046 20.5 0.0 0.0012 19.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.6 EWC46149.1 - 0.0015 17.2 0.0 0.0025 16.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_12 PF08242.7 EWC46149.1 - 0.0017 18.7 0.0 0.0041 17.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 EWC46149.1 - 0.022 13.8 0.0 0.036 13.1 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_24 PF13578.1 EWC46149.1 - 0.033 14.9 0.0 0.077 13.8 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain PGP_phosphatase PF09419.5 EWC46149.1 - 0.049 12.9 0.0 0.8 9.0 0.0 2.4 2 0 0 2 2 2 0 Mitochondrial PGP phosphatase Methyltransf_32 PF13679.1 EWC46149.1 - 0.099 12.3 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain CDC73 PF05179.9 EWC46150.1 - 1e-37 130.0 1.1 1.1e-37 129.9 0.8 1.0 1 0 0 1 1 1 1 RNA pol II accessory factor, Cdc73 family Sld5 PF05916.6 EWC46152.1 - 1.2e-19 70.5 0.1 1.8e-19 69.9 0.1 1.3 1 0 0 1 1 1 1 GINS complex protein HCNGP PF07818.8 EWC46153.1 - 6.2e-17 61.4 0.0 1.2e-16 60.5 0.0 1.4 1 0 0 1 1 1 1 HCNGP-like protein MIP-T3 PF10243.4 EWC46153.1 - 0.043 12.2 9.4 0.09 11.2 6.5 1.4 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 DUF1777 PF08648.7 EWC46153.1 - 0.12 12.1 44.2 0.25 11.0 30.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1777) Proteasome PF00227.21 EWC46154.1 - 9.8e-33 113.0 0.3 1.9e-32 112.1 0.2 1.5 1 1 0 1 1 1 1 Proteasome subunit zf-RING_2 PF13639.1 EWC46155.1 - 1.4e-10 40.8 8.8 1.4e-10 40.8 6.1 2.3 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.1 EWC46155.1 - 2.1e-10 40.4 8.2 2.1e-10 40.4 5.7 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EWC46155.1 - 1.1e-07 31.4 6.0 1.1e-07 31.4 4.1 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 EWC46155.1 - 5.2e-07 29.2 9.1 5.2e-07 29.2 6.3 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 EWC46155.1 - 6.9e-07 29.0 8.9 6.9e-07 29.0 6.2 2.1 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 EWC46155.1 - 1.4e-05 24.7 2.5 3.2e-05 23.5 1.7 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_6 PF14835.1 EWC46155.1 - 2.2e-05 24.1 4.6 2.2e-05 24.1 3.2 1.6 2 0 0 2 2 1 1 zf-RING of BARD1-type protein zf-RING_5 PF14634.1 EWC46155.1 - 3.9e-05 23.2 9.4 3.9e-05 23.2 6.5 2.4 2 2 1 3 3 3 1 zinc-RING finger domain zf-rbx1 PF12678.2 EWC46155.1 - 0.00064 19.7 11.1 0.0011 19.0 4.4 2.4 2 0 0 2 2 2 1 RING-H2 zinc finger zinc_ribbon_2 PF13240.1 EWC46155.1 - 0.096 12.2 2.8 0.33 10.4 0.3 2.6 2 0 0 2 2 2 0 zinc-ribbon domain DZR PF12773.2 EWC46155.1 - 0.72 9.7 15.7 0.58 10.0 0.5 2.8 2 1 1 3 3 2 0 Double zinc ribbon IBR PF01485.16 EWC46155.1 - 1.8 8.4 17.2 32 4.5 6.8 2.7 1 1 1 2 2 2 0 IBR domain DUF3537 PF12056.3 EWC46155.1 - 4.5 5.8 5.3 0.42 9.2 0.3 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3537) zf-ribbon_3 PF13248.1 EWC46155.1 - 4.8 6.5 11.3 0.28 10.4 0.5 2.8 3 0 0 3 3 3 0 zinc-ribbon domain Adaptin_N PF01602.15 EWC46156.1 - 2.1e-99 333.2 0.0 1.4e-98 330.5 0.0 2.0 1 1 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.2 EWC46156.1 - 1.5e-08 34.7 0.9 1.2e-06 28.5 0.1 2.5 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.1 EWC46156.1 - 2e-07 31.1 0.6 0.001 19.3 0.0 4.2 3 1 0 3 3 3 2 HEAT repeats HEAT PF02985.17 EWC46156.1 - 0.00022 21.0 1.1 4.8 7.5 0.0 4.8 5 0 0 5 5 5 1 HEAT repeat HEAT_EZ PF13513.1 EWC46156.1 - 0.12 12.9 3.4 47 4.6 0.0 5.7 8 0 0 8 8 8 0 HEAT-like repeat BLVR PF06375.6 EWC46156.1 - 0.51 10.1 10.3 0.53 10.1 0.0 3.1 2 1 1 3 3 3 0 Bovine leukaemia virus receptor (BLVR) Proteasome PF00227.21 EWC46157.1 - 3.1e-26 91.8 0.0 3.8e-26 91.5 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Rad33 PF08730.5 EWC46157.1 - 0.14 11.6 0.0 0.23 10.9 0.0 1.3 1 0 0 1 1 1 0 Rad33 TPR_11 PF13414.1 EWC46158.1 - 3.8e-11 42.4 9.6 4.4e-07 29.4 0.7 3.9 2 1 2 4 4 4 3 TPR repeat TPR_2 PF07719.12 EWC46158.1 - 2.3e-10 39.5 3.2 0.0019 17.9 0.4 5.0 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_1 PF00515.23 EWC46158.1 - 6.1e-08 31.9 7.1 0.00045 19.7 0.5 4.9 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.1 EWC46158.1 - 2.5e-07 30.9 5.4 9e-06 25.9 0.5 3.6 2 1 1 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.1 EWC46158.1 - 4.8e-06 26.3 5.2 0.00058 19.8 0.3 4.4 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.1 EWC46158.1 - 4.1e-05 23.8 7.1 0.0063 17.0 0.0 5.3 3 1 3 6 6 5 2 Tetratricopeptide repeat TPR_6 PF13174.1 EWC46158.1 - 8.3e-05 22.7 4.9 7 7.3 0.0 4.8 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_16 PF13432.1 EWC46158.1 - 0.00092 19.8 7.2 0.51 11.0 0.0 4.7 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.1 EWC46158.1 - 0.002 17.7 5.3 0.27 11.1 0.8 4.4 5 0 0 5 5 5 1 Tetratricopeptide repeat Apc3 PF12895.2 EWC46158.1 - 0.0032 17.5 1.1 0.013 15.6 0.2 2.4 3 0 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.1 EWC46158.1 - 0.0038 17.1 5.8 0.086 12.7 0.5 3.9 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_9 PF13371.1 EWC46158.1 - 0.0052 16.6 0.1 0.017 14.9 0.1 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat BTAD PF03704.12 EWC46158.1 - 0.073 13.3 0.0 1.8 8.8 0.0 2.4 2 0 0 2 2 2 0 Bacterial transcriptional activator domain ChAPs PF09295.5 EWC46158.1 - 0.075 11.7 0.2 0.099 11.3 0.1 1.1 1 0 0 1 1 1 0 ChAPs (Chs5p-Arf1p-binding proteins) Hormone_3 PF00159.13 EWC46158.1 - 0.41 10.6 1.8 0.67 10.0 0.1 2.2 3 0 0 3 3 3 0 Pancreatic hormone peptide Syja_N PF02383.13 EWC46159.1 - 1.4e-83 280.3 0.0 1.9e-83 279.8 0.0 1.1 1 0 0 1 1 1 1 SacI homology domain Exo_endo_phos PF03372.18 EWC46159.1 - 1.7e-26 93.7 0.1 3e-26 92.8 0.1 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Pkinase PF00069.20 EWC46163.1 - 1.6e-69 233.9 0.1 6.3e-69 231.9 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC46163.1 - 9.6e-51 172.3 0.0 3.3e-50 170.5 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Ilm1 PF10311.4 EWC46164.1 - 1.6e-31 109.0 0.6 1.8e-31 108.8 0.4 1.0 1 0 0 1 1 1 1 Increased loss of mitochondrial DNA protein 1 Pkinase PF00069.20 EWC46165.1 - 3.2e-51 174.0 0.0 4.8e-51 173.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC46165.1 - 4.8e-28 97.9 0.0 7.1e-28 97.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EWC46165.1 - 4.6e-10 38.9 0.0 7.2e-10 38.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 EWC46165.1 - 0.018 14.1 0.0 0.041 12.9 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.6 EWC46165.1 - 0.076 11.8 0.0 0.12 11.1 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 DUF1903 PF08991.5 EWC46166.1 - 0.0012 18.9 1.4 0.0022 18.0 0.9 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1903) COX6B PF02297.12 EWC46166.1 - 0.003 17.5 3.0 0.0051 16.8 2.1 1.5 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb CHCH PF06747.8 EWC46166.1 - 0.0049 16.7 4.3 0.014 15.2 2.8 1.9 1 1 1 2 2 2 1 CHCH domain Cmc1 PF08583.5 EWC46166.1 - 0.05 13.3 3.0 1.5 8.6 0.3 2.5 1 1 1 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like NatB_MDM20 PF09797.4 EWC46167.1 - 5.4e-60 203.0 0.1 8.8e-60 202.3 0.0 1.3 1 0 0 1 1 1 1 N-acetyltransferase B complex (NatB) non catalytic subunit Fungal_trans_2 PF11951.3 EWC46168.1 - 3e-22 78.7 1.1 7.4e-21 74.1 0.8 2.1 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EWC46168.1 - 0.014 15.2 1.4 0.027 14.3 1.0 1.4 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Ecm29 PF13001.2 EWC46169.1 - 2.8e-80 270.2 0.0 5.8e-80 269.1 0.0 1.6 1 0 0 1 1 1 1 Proteasome stabiliser Vac14_Fab1_bd PF12755.2 EWC46169.1 - 1.6e-06 28.3 0.2 0.00033 20.9 0.0 4.3 3 2 0 3 3 3 1 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.1 EWC46169.1 - 4.3e-06 27.0 7.3 8.4 7.0 0.0 8.7 7 3 3 10 10 10 3 HEAT-like repeat CLASP_N PF12348.3 EWC46169.1 - 0.00017 21.0 0.6 0.42 9.9 0.0 4.8 4 1 0 5 5 5 1 CLASP N terminal HEAT PF02985.17 EWC46169.1 - 0.0002 21.1 12.7 0.77 10.0 0.0 9.5 12 0 0 12 12 12 2 HEAT repeat VHS PF00790.14 EWC46169.1 - 0.059 12.9 0.0 0.33 10.5 0.0 2.4 1 0 0 1 1 1 0 VHS domain ADH_N PF08240.7 EWC46170.1 - 5e-30 103.4 2.1 8.2e-30 102.7 1.5 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 EWC46170.1 - 1.5e-17 63.3 0.0 2.3e-17 62.7 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_assoc PF13823.1 EWC46170.1 - 2.9e-05 23.6 0.2 9.4e-05 21.9 0.1 2.0 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-associated NADH_4Fe-4S PF10589.4 EWC46170.1 - 4.7 6.4 6.4 11 5.2 4.4 1.6 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region zf-H2C2_2 PF13465.1 EWC46171.1 - 6.2e-14 51.5 15.8 9.2e-08 32.0 1.0 3.5 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2 PF00096.21 EWC46171.1 - 3.9e-09 36.3 26.6 0.0059 16.8 0.0 3.5 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EWC46171.1 - 6.9e-06 26.0 26.2 0.1 13.0 0.1 3.5 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2HC_2 PF13913.1 EWC46171.1 - 0.0058 16.2 6.0 0.0067 16.0 0.4 2.4 2 0 0 2 2 2 1 zinc-finger of a C2HC-type bZIP_1 PF00170.16 EWC46171.1 - 0.059 13.3 0.5 0.14 12.1 0.3 1.5 1 0 0 1 1 1 0 bZIP transcription factor zf-C2H2_jaz PF12171.3 EWC46171.1 - 0.075 13.2 16.6 6.6 7.0 0.0 3.3 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.5 EWC46171.1 - 0.23 11.4 9.1 11 6.0 0.2 3.2 1 1 2 3 3 3 0 Zinc ribbon domain zf-C2H2_6 PF13912.1 EWC46171.1 - 0.59 10.1 16.1 2.2 8.3 2.3 3.3 3 0 0 3 3 3 0 C2H2-type zinc finger zf-CHY PF05495.7 EWC46171.1 - 0.82 9.8 8.2 1.9 8.7 5.7 1.6 1 0 0 1 1 1 0 CHY zinc finger zinc_ribbon_5 PF13719.1 EWC46171.1 - 1.4 8.5 5.9 10 5.8 0.2 3.1 3 0 0 3 3 3 0 zinc-ribbon domain DUF1908 PF08926.6 EWC46171.1 - 1.6 7.3 7.1 0.055 12.2 0.7 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1908) zinc_ribbon_4 PF13717.1 EWC46171.1 - 1.8 8.3 6.1 11 5.7 0.2 3.1 3 0 0 3 3 3 0 zinc-ribbon domain DZR PF12773.2 EWC46171.1 - 2.1 8.2 6.9 16 5.3 4.8 2.1 1 1 1 2 2 2 0 Double zinc ribbon LIM PF00412.17 EWC46171.1 - 2.1 8.4 7.2 14 5.8 5.4 1.9 1 1 1 2 2 2 0 LIM domain zinc-ribbons_6 PF07191.7 EWC46171.1 - 3.9 7.3 6.3 3 7.7 1.9 2.1 2 0 0 2 2 2 0 zinc-ribbons zf-LYAR PF08790.6 EWC46171.1 - 7.7 6.3 7.0 5.5 6.7 0.3 2.5 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger zf-C2H2_2 PF12756.2 EWC46171.1 - 9 6.4 17.9 8.3 6.5 4.4 3.1 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) YTH PF04146.10 EWC46173.1 - 3.6e-54 182.1 0.0 5.4e-54 181.5 0.0 1.3 1 0 0 1 1 1 1 YT521-B-like domain RRM_1 PF00076.17 EWC46173.1 - 7.2e-07 28.7 0.0 1.5e-06 27.7 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EWC46173.1 - 2.7e-05 24.0 0.0 5.5e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EWC46173.1 - 0.003 17.3 0.1 0.0066 16.2 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) IGR PF09597.5 EWC46174.1 - 3.2e-18 65.3 0.0 4.7e-18 64.8 0.0 1.3 1 0 0 1 1 1 1 IGR protein motif Pkinase PF00069.20 EWC46175.1 - 3.5e-60 203.3 0.0 4.4e-60 203.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC46175.1 - 4.1e-31 107.9 0.0 5.4e-31 107.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Seadorna_VP7 PF07387.6 EWC46175.1 - 0.05 12.4 0.0 0.079 11.7 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Kinase-like PF14531.1 EWC46175.1 - 0.06 12.2 0.0 0.11 11.4 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Kinesin PF00225.18 EWC46176.1 - 9.7e-97 323.6 0.0 2.2e-96 322.4 0.0 1.5 2 0 0 2 2 2 1 Kinesin motor domain DAGAT PF03982.8 EWC46177.1 - 6.5e-86 287.6 0.0 1.1e-51 175.3 0.0 2.1 2 0 0 2 2 2 2 Diacylglycerol acyltransferase Stk19 PF10494.4 EWC46178.1 - 2.6e-32 112.1 0.0 3.3e-32 111.8 0.0 1.1 1 0 0 1 1 1 1 Serine-threonine protein kinase 19 Ribonuc_L-PSP PF01042.16 EWC46178.1 - 0.0072 16.0 0.0 0.013 15.2 0.0 1.3 1 0 0 1 1 1 1 Endoribonuclease L-PSP Pox_E2-like PF04497.7 EWC46178.1 - 0.11 10.4 0.0 4.4 5.1 0.0 2.0 2 0 0 2 2 2 0 Poxviridae protein MARVEL PF01284.18 EWC46179.1 - 1.9e-06 27.7 24.5 1.4e-05 24.9 16.8 2.0 1 1 0 1 1 1 1 Membrane-associating domain FA_desaturase PF00487.19 EWC46179.1 - 0.3 10.4 6.6 0.13 11.6 1.9 1.9 2 0 0 2 2 2 0 Fatty acid desaturase MHYT PF03707.11 EWC46179.1 - 7 6.8 10.1 0.62 10.2 1.8 2.8 2 1 1 3 3 3 0 Bacterial signalling protein N terminal repeat SWIM PF04434.12 EWC46181.1 - 0.088 12.3 0.3 0.17 11.3 0.2 1.5 1 0 0 1 1 1 0 SWIM zinc finger ADH_zinc_N PF00107.21 EWC46183.1 - 9.3e-24 83.4 0.0 1.6e-23 82.6 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 EWC46183.1 - 4.7e-09 37.2 0.1 1.9e-08 35.2 0.0 2.0 2 0 0 2 2 2 1 Zinc-binding dehydrogenase NUDIX PF00293.23 EWC46185.1 - 7.8e-15 54.7 0.1 1.2e-14 54.0 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain Kelch_5 PF13854.1 EWC46187.1 - 3.9e-15 55.4 1.5 9.7e-09 35.0 0.8 5.1 5 0 0 5 5 5 1 Kelch motif Kelch_6 PF13964.1 EWC46187.1 - 4.7e-06 26.5 2.8 2.5 8.3 0.1 5.9 5 1 0 5 5 5 1 Kelch motif Kelch_2 PF07646.10 EWC46187.1 - 5e-06 26.0 0.0 4.7 7.1 0.0 4.7 4 0 0 4 4 4 2 Kelch motif Herpes_gE PF02480.11 EWC46187.1 - 0.0011 17.3 0.1 0.0018 16.6 0.1 1.2 1 0 0 1 1 1 1 Alphaherpesvirus glycoprotein E Kelch_1 PF01344.20 EWC46187.1 - 0.0014 18.1 5.0 7.9 6.1 0.1 5.1 5 1 0 5 5 5 1 Kelch motif TMEM154 PF15102.1 EWC46187.1 - 0.0066 16.1 0.2 0.016 14.8 0.0 1.7 2 0 0 2 2 2 1 TMEM154 protein family Shisa PF13908.1 EWC46187.1 - 0.012 15.7 0.3 0.031 14.4 0.2 1.6 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF4448 PF14610.1 EWC46187.1 - 0.016 14.7 0.1 0.032 13.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) EphA2_TM PF14575.1 EWC46187.1 - 0.018 15.4 0.0 0.037 14.4 0.0 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF4381 PF14316.1 EWC46187.1 - 0.13 12.3 0.0 0.44 10.6 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) DUF912 PF06024.7 EWC46187.1 - 0.14 12.2 0.0 0.25 11.3 0.0 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Rifin_STEVOR PF02009.11 EWC46187.1 - 0.22 11.1 0.0 0.33 10.5 0.0 1.2 1 0 0 1 1 1 0 Rifin/stevor family DUF4366 PF14283.1 EWC46187.1 - 0.24 10.7 0.0 0.4 10.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) CFEM PF05730.6 EWC46188.1 - 2.6e-08 33.5 6.2 5.4e-08 32.5 4.3 1.6 1 1 0 1 1 1 1 CFEM domain Fungal_trans_2 PF11951.3 EWC46189.1 - 2.2e-17 62.7 0.1 3.3e-17 62.1 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Glyco_hydro_3 PF00933.16 EWC46190.1 - 2e-53 181.3 0.0 2.9e-53 180.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Acetyltransf_1 PF00583.19 EWC46190.1 - 3.9e-06 26.8 0.0 1.4e-05 25.0 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Glyco_hydro_3_C PF01915.17 EWC46190.1 - 1.8e-05 24.3 0.0 3.2e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Acetyltransf_10 PF13673.1 EWC46190.1 - 0.026 14.6 0.0 0.059 13.4 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Xan_ur_permease PF00860.15 EWC46191.1 - 1.8e-25 89.2 34.6 1.2e-24 86.6 23.2 2.2 2 1 0 2 2 2 1 Permease family Methyltransf_11 PF08241.7 EWC46192.1 - 4.4e-07 30.3 0.0 8.3e-07 29.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EWC46192.1 - 6.4e-05 22.7 0.0 0.00011 21.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EWC46192.1 - 0.0085 15.2 0.0 0.015 14.4 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family VirB8 PF04335.8 EWC46193.1 - 0.16 11.4 0.2 0.39 10.2 0.2 1.6 1 0 0 1 1 1 0 VirB8 protein DUF2304 PF10066.4 EWC46193.1 - 4.1 7.2 9.5 0.51 10.2 1.9 2.7 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2304) DUF3621 PF12285.3 EWC46194.1 - 0.0036 17.4 0.3 0.013 15.6 0.2 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF3621) Glu_synthase PF01645.12 EWC46194.1 - 0.12 11.2 0.0 0.18 10.7 0.0 1.1 1 0 0 1 1 1 0 Conserved region in glutamate synthase Pyr_redox_3 PF13738.1 EWC46195.1 - 1.1e-21 77.7 0.0 3.4e-21 76.2 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 EWC46195.1 - 2.7e-12 46.2 0.0 1.5e-10 40.5 0.0 2.8 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) FMO-like PF00743.14 EWC46195.1 - 1.6e-06 26.6 0.0 2.7e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.9 EWC46195.1 - 9.5e-06 25.6 0.0 2.4e-05 24.3 0.0 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 EWC46195.1 - 0.002 17.2 0.2 0.013 14.6 0.1 2.0 2 0 0 2 2 2 1 Thi4 family NAD_binding_9 PF13454.1 EWC46195.1 - 0.0023 17.7 0.0 0.016 14.9 0.0 2.3 2 1 0 2 2 2 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.1 EWC46195.1 - 0.0025 17.7 0.0 0.0073 16.3 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 EWC46195.1 - 0.046 12.6 0.0 1.4 7.7 0.0 2.9 3 0 0 3 3 3 0 FAD dependent oxidoreductase Hexokinase_1 PF00349.16 EWC46196.1 - 2e-30 105.7 0.0 3.8e-30 104.7 0.0 1.4 2 0 0 2 2 2 1 Hexokinase Hexokinase_2 PF03727.11 EWC46196.1 - 2.8e-16 59.4 0.0 3.9e-16 59.0 0.0 1.2 1 0 0 1 1 1 1 Hexokinase NDT80_PhoG PF05224.7 EWC46197.1 - 1.3e-30 106.8 0.0 3.5e-30 105.3 0.0 1.8 2 0 0 2 2 2 1 NDT80 / PhoG like DNA-binding family MFS_1 PF07690.11 EWC46198.1 - 1.2e-13 50.5 28.9 1.2e-13 50.5 20.0 1.7 2 1 0 2 2 2 1 Major Facilitator Superfamily UNC-93 PF05978.11 EWC46198.1 - 1.8e-13 50.3 4.5 1.8e-13 50.3 3.1 2.6 2 1 0 2 2 2 1 Ion channel regulatory protein UNC-93 Glucosamine_iso PF01182.15 EWC46199.1 - 1.5e-16 60.6 0.0 2.2e-16 60.1 0.0 1.3 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Sugar-bind PF04198.8 EWC46199.1 - 0.0031 16.4 0.1 0.004 16.0 0.0 1.1 1 0 0 1 1 1 1 Putative sugar-binding domain DUF4449 PF14613.1 EWC46200.1 - 1.1e-05 25.3 0.9 0.0001 22.3 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF4449) Pex19 PF04614.7 EWC46200.1 - 0.042 13.4 6.1 0.38 10.3 0.2 2.2 1 1 0 2 2 2 0 Pex19 protein family Phage_HK97_TLTM PF06120.6 EWC46200.1 - 0.16 11.2 3.5 0.74 9.1 1.1 2.2 2 0 0 2 2 2 0 Tail length tape measure protein DUF4360 PF14273.1 EWC46201.1 - 8.3e-58 195.0 2.4 9.7e-58 194.8 1.6 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4360) DUF237 PF03072.9 EWC46201.1 - 0.058 13.2 0.0 0.091 12.6 0.0 1.3 1 0 0 1 1 1 0 MG032/MG096/MG288 family 1 Fungal_trans PF04082.13 EWC46203.1 - 8.6e-57 191.9 0.1 1.5e-56 191.1 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.21 EWC46203.1 - 0.00094 19.3 3.3 0.00094 19.3 2.3 3.3 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EWC46203.1 - 0.0049 17.1 1.9 0.0049 17.1 1.3 4.2 4 0 0 4 4 4 2 C2H2-type zinc finger AMP-binding PF00501.23 EWC46204.1 - 6.5e-171 568.3 0.0 2.4e-87 293.0 0.0 2.3 2 0 0 2 2 2 2 AMP-binding enzyme Condensation PF00668.15 EWC46204.1 - 3.8e-131 436.4 0.0 4.7e-38 130.7 0.0 5.7 5 1 0 5 5 5 5 Condensation domain PP-binding PF00550.20 EWC46204.1 - 3.9e-37 126.3 12.7 2e-09 37.5 0.1 5.7 6 0 0 6 6 6 4 Phosphopantetheine attachment site DUF229 PF02995.12 EWC46204.1 - 0.34 9.2 1.5 1.4 7.2 0.1 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF229) K_oxygenase PF13434.1 EWC46205.1 - 2e-111 372.2 0.0 2.3e-111 371.9 0.0 1.0 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.1 EWC46205.1 - 8.1e-10 38.6 0.8 1.5e-07 31.3 0.0 2.9 2 1 0 2 2 2 2 FAD-NAD(P)-binding Pyr_redox_3 PF13738.1 EWC46205.1 - 9.6e-09 35.5 0.0 2e-07 31.2 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Asp_protease PF09668.5 EWC46206.1 - 3.3e-60 201.1 0.0 4.8e-60 200.5 0.0 1.2 1 0 0 1 1 1 1 Aspartyl protease Asp_protease_2 PF13650.1 EWC46206.1 - 3.4e-12 46.7 0.0 9.3e-12 45.2 0.0 1.8 1 0 0 1 1 1 1 Aspartyl protease ubiquitin PF00240.18 EWC46206.1 - 1.1e-09 37.5 0.0 2.1e-09 36.6 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family gag-asp_proteas PF13975.1 EWC46206.1 - 8.8e-08 31.8 0.1 3.6e-07 29.9 0.0 2.0 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease UBA PF00627.26 EWC46206.1 - 2.1e-07 30.5 0.0 5.1e-07 29.3 0.0 1.7 1 0 0 1 1 1 1 UBA/TS-N domain RVP_2 PF08284.6 EWC46206.1 - 6e-07 29.4 0.0 1.2e-06 28.4 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease RVP PF00077.15 EWC46206.1 - 0.00035 20.4 0.0 0.001 18.9 0.0 1.8 1 1 0 1 1 1 1 Retroviral aspartyl protease RuvA_C PF07499.8 EWC46206.1 - 0.0088 16.1 0.9 0.02 15.0 0.1 2.0 2 0 0 2 2 2 1 RuvA, C-terminal domain UBA_4 PF14555.1 EWC46206.1 - 0.072 12.6 0.1 0.15 11.5 0.0 1.6 1 0 0 1 1 1 0 UBA-like domain RNA_pol_I_TF PF04090.7 EWC46207.1 - 7.6e-14 51.4 0.1 4.9e-13 48.8 0.1 2.1 2 1 0 2 2 2 1 RNA polymerase I specific initiation factor TAF1_subA PF14929.1 EWC46207.1 - 0.0029 16.1 0.0 0.0036 15.8 0.0 1.1 1 0 0 1 1 1 1 TAF RNA Polymerase I subunit A BRO1 PF03097.13 EWC46208.1 - 1.2e-127 425.7 1.9 1.2e-127 425.7 1.3 2.5 3 0 0 3 3 3 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.1 EWC46208.1 - 4.2e-76 255.7 20.4 7.8e-76 254.8 14.2 1.5 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV PAT1 PF09770.4 EWC46208.1 - 0.27 9.4 49.0 0.44 8.7 34.0 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF605 PF04652.11 EWC46208.1 - 1.2 8.4 32.7 3.3 7.0 22.6 1.7 1 0 0 1 1 1 0 Vta1 like Entericidin PF08085.6 EWC46208.1 - 4.7 7.1 5.6 25 4.8 0.3 3.6 4 0 0 4 4 4 0 Entericidin EcnA/B family CN_hydrolase PF00795.17 EWC46209.1 - 3.3e-25 88.5 0.0 6.7e-24 84.2 0.0 2.0 2 0 0 2 2 2 2 Carbon-nitrogen hydrolase Podoplanin PF05808.6 EWC46210.1 - 0.048 13.2 0.3 0.1 12.1 0.2 1.5 1 0 0 1 1 1 0 Podoplanin DUF2407_C PF13373.1 EWC46210.1 - 0.056 13.3 0.1 0.13 12.1 0.1 1.5 1 1 0 1 1 1 0 DUF2407 C-terminal domain NUDIX_4 PF14815.1 EWC46210.1 - 0.11 11.9 1.2 0.19 11.1 0.9 1.3 1 0 0 1 1 1 0 NUDIX domain Yip1 PF04893.12 EWC46211.1 - 2e-11 43.6 14.1 2.6e-11 43.3 9.8 1.1 1 0 0 1 1 1 1 Yip1 domain DUF4199 PF13858.1 EWC46211.1 - 0.4 10.5 7.1 0.58 10.0 4.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) Erg28 PF03694.8 EWC46212.1 - 6.3e-43 145.2 0.1 7.9e-43 144.9 0.1 1.1 1 0 0 1 1 1 1 Erg28 like protein TPR_19 PF14559.1 EWC46213.1 - 0.0036 17.6 0.8 0.021 15.1 0.1 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.1 EWC46213.1 - 0.084 13.5 1.1 14 6.6 0.3 3.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.1 EWC46213.1 - 0.24 11.3 4.7 0.23 11.4 0.8 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF1777 PF08648.7 EWC46214.1 - 0.0036 17.0 33.1 0.0036 17.0 23.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF1777) Zip PF02535.17 EWC46214.1 - 4.3 6.2 4.0 8.2 5.3 2.8 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter Tic20 PF09685.5 EWC46215.1 - 1.7e-05 24.7 1.0 2.4e-05 24.2 0.7 1.2 1 0 0 1 1 1 1 Tic20-like protein ATG27 PF09451.5 EWC46215.1 - 0.096 11.8 0.2 0.13 11.4 0.1 1.1 1 0 0 1 1 1 0 Autophagy-related protein 27 DUF3042 PF11240.3 EWC46216.1 - 0.073 12.8 1.1 0.19 11.5 0.8 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3042) Syndecan PF01034.15 EWC46216.1 - 0.078 12.6 0.1 0.18 11.5 0.1 1.5 1 0 0 1 1 1 0 Syndecan domain PAP1 PF08601.5 EWC46216.1 - 0.99 9.0 15.4 1.4 8.5 10.7 1.2 1 0 0 1 1 1 0 Transcription factor PAP1 Dicty_REP PF05086.7 EWC46216.1 - 1.9 6.1 3.3 2.4 5.8 2.3 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein SH3_1 PF00018.23 EWC46217.1 - 3.2e-07 29.6 0.0 7.4e-07 28.4 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.12 EWC46217.1 - 0.00022 20.6 0.0 0.001 18.4 0.0 2.1 2 0 0 2 2 2 1 Variant SH3 domain SH3_9 PF14604.1 EWC46217.1 - 0.00087 18.8 0.0 0.0025 17.3 0.0 1.8 1 1 0 1 1 1 1 Variant SH3 domain Not1 PF04054.10 EWC46218.1 - 6.2e-123 410.4 0.1 1.2e-122 409.4 0.1 1.5 1 0 0 1 1 1 1 CCR4-Not complex component, Not1 DUF3819 PF12842.2 EWC46218.1 - 3.4e-52 176.0 2.1 1.5e-51 173.9 1.5 2.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3819) ETF_QO PF05187.8 EWC46220.1 - 9.5e-45 151.1 0.0 1.5e-44 150.4 0.0 1.3 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase DAO PF01266.19 EWC46220.1 - 2.9e-09 36.2 0.2 0.00034 19.6 0.0 3.1 3 0 0 3 3 3 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EWC46220.1 - 1.8e-08 34.2 0.0 4.4e-08 33.0 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 EWC46220.1 - 8.2e-08 31.5 0.9 0.00033 19.6 0.7 2.4 2 0 0 2 2 2 2 FAD binding domain FAD_oxidored PF12831.2 EWC46220.1 - 1.2e-06 27.8 0.0 2.1e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.12 EWC46220.1 - 1.8e-05 23.9 0.0 0.00095 18.3 0.0 2.1 2 0 0 2 2 2 1 Thi4 family Pyr_redox_2 PF07992.9 EWC46220.1 - 0.00043 20.2 0.0 0.0007 19.5 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 EWC46220.1 - 0.001 18.1 0.3 0.0023 17.0 0.2 1.6 1 1 0 1 1 1 1 FAD binding domain NAD_binding_9 PF13454.1 EWC46220.1 - 0.0014 18.3 0.1 0.0046 16.7 0.1 1.8 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox_3 PF13738.1 EWC46220.1 - 0.0015 18.6 0.0 0.0041 17.2 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 EWC46220.1 - 0.0015 17.0 0.5 0.0025 16.3 0.3 1.3 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox PF00070.22 EWC46220.1 - 0.0093 16.3 0.0 11 6.4 0.1 3.3 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 EWC46220.1 - 0.0094 14.9 0.2 0.027 13.3 0.2 1.7 2 0 0 2 2 2 1 Lycopene cyclase protein Fer4_7 PF12838.2 EWC46220.1 - 0.026 14.9 0.6 0.068 13.5 0.4 1.7 1 0 0 1 1 1 0 4Fe-4S dicluster domain Trp_halogenase PF04820.9 EWC46220.1 - 0.028 13.0 0.1 0.077 11.6 0.1 1.6 2 0 0 2 2 2 0 Tryptophan halogenase GIDA PF01134.17 EWC46220.1 - 0.12 11.1 0.3 0.17 10.6 0.2 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A TBP PF00352.16 EWC46221.1 - 3.6e-70 231.3 0.1 4.1e-35 119.0 0.0 2.2 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.3 EWC46221.1 - 7.7e-05 22.6 0.0 0.27 11.2 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) DAO PF01266.19 EWC46222.1 - 2.3e-45 155.0 6.3 3.6e-45 154.4 4.4 1.3 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EWC46222.1 - 4.6e-05 23.3 0.0 0.00011 22.1 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.17 EWC46222.1 - 0.00011 21.2 0.0 0.00052 19.0 0.0 1.9 2 0 0 2 2 2 1 Glucose inhibited division protein A Pyr_redox_2 PF07992.9 EWC46222.1 - 0.00019 21.3 0.0 0.026 14.4 0.0 3.0 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 EWC46222.1 - 0.0018 18.0 0.0 0.057 13.1 0.0 2.3 2 0 0 2 2 2 1 FAD-NAD(P)-binding Trp_halogenase PF04820.9 EWC46222.1 - 0.076 11.6 0.0 0.65 8.5 0.0 2.0 2 0 0 2 2 2 0 Tryptophan halogenase Methyltransf_23 PF13489.1 EWC46223.1 - 2.1e-15 56.7 0.0 3.3e-15 56.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EWC46223.1 - 1.8e-07 30.8 0.0 2.9e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EWC46223.1 - 2.1e-07 31.3 0.0 4e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EWC46223.1 - 4.7e-06 25.8 0.0 7.4e-06 25.2 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_18 PF12847.2 EWC46223.1 - 1.8e-05 25.2 0.0 3.4e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EWC46223.1 - 0.00089 19.6 0.0 0.0025 18.2 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 EWC46223.1 - 0.0023 18.2 0.0 0.0053 17.0 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain NST1 PF13945.1 EWC46225.1 - 3.1e-52 177.4 21.0 3.1e-52 177.4 14.6 5.9 4 2 1 5 5 5 2 Salt tolerance down-regulator Ras PF00071.17 EWC46226.1 - 7.3e-51 171.7 0.0 8.8e-51 171.5 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EWC46226.1 - 6.6e-17 62.1 0.0 9.7e-17 61.5 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EWC46226.1 - 1.1e-08 34.4 0.0 1.7e-08 33.9 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 EWC46226.1 - 0.00018 21.0 0.0 0.0018 17.7 0.0 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 EWC46226.1 - 0.0065 15.6 0.0 0.009 15.1 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region PduV-EutP PF10662.4 EWC46226.1 - 0.008 15.6 0.0 1.7 8.1 0.0 2.4 2 0 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation DUF1611 PF07755.6 EWC46226.1 - 0.023 13.3 0.0 0.03 12.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1611) SRPRB PF09439.5 EWC46226.1 - 0.039 13.1 0.0 0.049 12.8 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.18 EWC46226.1 - 0.099 12.6 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_21 PF13304.1 EWC46226.1 - 0.15 12.0 0.0 0.22 11.4 0.0 1.2 1 0 0 1 1 1 0 AAA domain DUF1749 PF08538.5 EWC46227.1 - 2.4e-63 213.8 0.0 5.1e-63 212.7 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1749) Ndc80_HEC PF03801.8 EWC46227.1 - 3e-46 156.7 0.0 7.1e-46 155.5 0.0 1.6 1 0 0 1 1 1 1 HEC/Ndc80p family Abhydrolase_6 PF12697.2 EWC46227.1 - 2.7e-06 27.4 0.0 6e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EWC46227.1 - 0.00012 21.8 0.0 0.00027 20.6 0.0 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF900 PF05990.7 EWC46227.1 - 0.0012 18.1 0.0 0.004 16.5 0.0 1.7 2 0 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF900) Ser_hydrolase PF06821.8 EWC46227.1 - 0.015 14.8 0.0 0.06 12.9 0.0 2.0 2 0 0 2 2 2 0 Serine hydrolase DUF4250 PF14056.1 EWC46227.1 - 0.082 12.6 4.9 20 4.9 0.0 4.3 4 0 0 4 4 4 0 Domain of unknown function (DUF4250) DUF745 PF05335.8 EWC46227.1 - 0.09 12.2 12.9 0.012 15.0 2.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF745) Spc7 PF08317.6 EWC46227.1 - 1.9 7.0 27.4 1.2 7.7 6.7 2.6 2 1 0 2 2 2 0 Spc7 kinetochore protein NPV_P10 PF05531.7 EWC46227.1 - 3.8 7.8 11.9 4.9 7.4 0.3 3.4 3 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein FliD_N PF02465.13 EWC46227.1 - 4.5 7.7 13.5 1.4 9.3 1.5 3.7 2 1 1 3 3 3 0 Flagellar hook-associated protein 2 N-terminus DUF3584 PF12128.3 EWC46227.1 - 5.6 4.1 29.9 1.6 5.9 8.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) TauD PF02668.11 EWC46228.1 - 9.1e-47 159.8 0.3 1.5e-46 159.1 0.2 1.3 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.7 EWC46228.1 - 3e-09 37.1 0.1 1e-08 35.4 0.0 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF971) CsiD PF08943.5 EWC46228.1 - 0.002 17.0 0.1 0.048 12.5 0.0 2.1 2 0 0 2 2 2 1 CsiD SusD-like_3 PF14322.1 EWC46228.1 - 0.13 12.2 0.0 0.26 11.2 0.0 1.4 1 0 0 1 1 1 0 Starch-binding associating with outer membrane TFR_dimer PF04253.10 EWC46229.1 - 2.4e-21 75.5 0.3 4.1e-21 74.8 0.2 1.4 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain PA PF02225.17 EWC46229.1 - 2.8e-09 36.5 0.3 7.2e-09 35.2 0.2 1.7 1 0 0 1 1 1 1 PA domain Peptidase_M28 PF04389.12 EWC46229.1 - 5.4e-05 22.9 0.1 0.00024 20.8 0.0 2.0 2 0 0 2 2 2 1 Peptidase family M28 Chordopox_A13L PF05961.6 EWC46229.1 - 0.00049 19.9 0.1 0.0013 18.6 0.1 1.7 1 0 0 1 1 1 1 Chordopoxvirus A13L protein FAD_binding_3 PF01494.14 EWC46231.1 - 4.6e-19 68.6 0.0 3.9e-18 65.6 0.0 2.1 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.19 EWC46231.1 - 2e-05 23.6 0.1 6.2e-05 22.0 0.3 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox PF00070.22 EWC46231.1 - 3.1e-05 24.2 0.2 0.00033 20.9 0.0 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase SE PF08491.5 EWC46231.1 - 8.6e-05 21.4 0.0 0.0012 17.7 0.0 2.0 2 0 0 2 2 2 1 Squalene epoxidase Pyr_redox_2 PF07992.9 EWC46231.1 - 0.0015 18.4 0.2 0.0024 17.7 0.1 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 EWC46231.1 - 0.0073 16.3 0.8 0.016 15.2 0.1 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain 3HCDH_N PF02737.13 EWC46231.1 - 0.0078 15.8 0.0 0.02 14.5 0.0 1.6 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain HI0933_like PF03486.9 EWC46231.1 - 0.0081 14.6 0.1 0.016 13.7 0.1 1.4 1 0 0 1 1 1 1 HI0933-like protein Trp_halogenase PF04820.9 EWC46231.1 - 0.0089 14.7 0.5 4.1 5.9 0.3 2.9 3 0 0 3 3 3 1 Tryptophan halogenase FAD_binding_2 PF00890.19 EWC46231.1 - 0.012 14.5 0.4 0.29 9.9 0.1 2.2 2 0 0 2 2 2 0 FAD binding domain GIDA PF01134.17 EWC46231.1 - 0.019 13.8 0.2 0.033 13.0 0.1 1.5 1 1 0 1 1 1 0 Glucose inhibited division protein A AlaDh_PNT_C PF01262.16 EWC46231.1 - 0.025 14.1 0.0 0.047 13.2 0.0 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.12 EWC46231.1 - 0.031 13.3 0.1 0.054 12.5 0.0 1.3 1 0 0 1 1 1 0 Thi4 family Mqo PF06039.10 EWC46231.1 - 0.055 11.6 0.0 0.097 10.8 0.0 1.3 1 0 0 1 1 1 0 Malate:quinone oxidoreductase (Mqo) ApbA PF02558.11 EWC46231.1 - 0.058 12.8 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA FAD_oxidored PF12831.2 EWC46231.1 - 0.078 12.0 1.6 0.57 9.2 1.1 2.1 1 1 0 1 1 1 0 FAD dependent oxidoreductase UDPG_MGDP_dh_N PF03721.9 EWC46231.1 - 0.086 12.2 0.2 0.15 11.4 0.2 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_7 PF13241.1 EWC46231.1 - 0.18 12.0 0.0 0.38 11.0 0.0 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding TLD PF07534.11 EWC46232.1 - 7e-28 97.3 0.0 2.3e-27 95.6 0.0 1.8 1 1 0 1 1 1 1 TLD MUG2_C PF08593.5 EWC46232.1 - 0.00013 22.1 0.1 0.00027 21.0 0.1 1.6 1 0 0 1 1 1 1 Meiotically up-regulated glycoproteins C-terminal DUF4473 PF14747.1 EWC46233.1 - 0.013 15.6 2.7 0.021 15.0 1.0 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4473) Cytochrom_C_2 PF01322.15 EWC46233.1 - 0.052 14.0 0.5 0.074 13.5 0.3 1.2 1 0 0 1 1 1 0 Cytochrome C' Phage_DsbA PF11126.3 EWC46233.1 - 0.13 12.3 0.6 0.2 11.7 0.4 1.3 1 0 0 1 1 1 0 Transcriptional regulator DsbA HATPase_c_2 PF13581.1 EWC46233.1 - 0.15 11.8 0.9 3.8 7.3 0.1 2.2 1 1 1 2 2 2 0 Histidine kinase-like ATPase domain PALP PF00291.20 EWC46235.1 - 7e-65 219.2 0.0 8.5e-65 218.9 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme SIS PF01380.17 EWC46236.1 - 1.1e-55 186.8 0.0 2.2e-31 108.1 0.0 2.2 2 0 0 2 2 2 2 SIS domain GATase_2 PF00310.16 EWC46236.1 - 6.1e-27 94.2 0.1 2.5e-19 69.2 0.0 2.4 2 0 0 2 2 2 2 Glutamine amidotransferases class-II GATase_6 PF13522.1 EWC46236.1 - 9.1e-19 67.7 0.0 2e-18 66.6 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.1 EWC46236.1 - 3.4e-12 46.2 0.0 8.3e-12 44.9 0.0 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.1 EWC46236.1 - 4e-07 28.9 0.1 1.2e-06 27.4 0.1 1.7 2 0 0 2 2 2 1 Glutamine amidotransferases class-II Peptidase_M19 PF01244.16 EWC46237.1 - 2e-106 355.5 0.0 2.4e-106 355.3 0.0 1.1 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) IF-2B PF01008.12 EWC46238.1 - 3.2e-59 200.2 1.5 3.5e-59 200.0 1.0 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family DMRL_synthase PF00885.14 EWC46239.1 - 1.3e-43 148.1 0.3 3.1e-26 91.7 0.0 2.1 2 0 0 2 2 2 2 6,7-dimethyl-8-ribityllumazine synthase DUF1841 PF08897.6 EWC46240.1 - 0.11 12.3 0.0 0.22 11.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1841) priB_priC PF07445.7 EWC46241.1 - 0.043 13.2 0.4 0.054 12.9 0.3 1.1 1 0 0 1 1 1 0 Primosomal replication protein priB and priC Acyl_transf_3 PF01757.17 EWC46243.1 - 5.5e-29 101.0 34.2 9e-29 100.3 23.7 1.3 1 1 0 1 1 1 1 Acyltransferase family DUF418 PF04235.7 EWC46243.1 - 0.0061 16.2 8.1 0.0061 16.2 5.6 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF418) HSP70 PF00012.15 EWC46244.1 - 7.9e-09 33.9 0.0 1.3e-08 33.2 0.0 1.3 1 0 0 1 1 1 1 Hsp70 protein UQ_con PF00179.21 EWC46245.1 - 4.7e-29 100.6 0.0 8.7e-29 99.7 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme VWA_2 PF13519.1 EWC46245.1 - 4e-13 49.8 0.0 7.7e-13 48.8 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.23 EWC46245.1 - 0.019 14.6 0.0 0.048 13.3 0.0 1.7 1 1 0 1 1 1 0 von Willebrand factor type A domain Redoxin PF08534.5 EWC46246.1 - 0.46 10.0 2.0 1.4 8.4 1.2 1.7 1 1 1 2 2 2 0 Redoxin AA_permease PF00324.16 EWC46247.1 - 1.3e-61 208.4 34.1 1.6e-61 208.0 23.6 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EWC46247.1 - 2.6e-17 62.4 40.5 4.1e-17 61.8 28.1 1.2 1 0 0 1 1 1 1 Amino acid permease CDC45 PF02724.9 EWC46247.1 - 0.53 8.2 2.7 0.83 7.6 1.9 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF4229 PF14012.1 EWC46247.1 - 2.9 7.8 12.8 0.14 12.1 2.6 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4229) EpsG PF14897.1 EWC46249.1 - 0.0044 15.9 0.8 0.0086 15.0 0.6 1.4 1 1 0 1 1 1 1 EpsG family Claudin_2 PF13903.1 EWC46249.1 - 0.78 9.4 7.6 0.25 10.9 2.1 2.0 2 0 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction Herpes_capsid PF06112.6 EWC46250.1 - 8.7 6.3 9.1 18 5.3 6.3 1.7 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein Condensation PF00668.15 EWC46251.1 - 0.00033 19.6 0.0 0.0015 17.4 0.0 2.0 1 1 0 1 1 1 1 Condensation domain adh_short PF00106.20 EWC46252.1 - 2.8e-29 102.1 0.0 5.1e-29 101.3 0.0 1.4 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.5 EWC46252.1 - 1.4e-12 47.6 0.0 3.3e-12 46.4 0.0 1.5 1 1 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 EWC46252.1 - 1.1e-11 45.0 0.0 2.8e-11 43.6 0.0 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.1 EWC46252.1 - 1.6e-06 28.2 0.0 7e-06 26.1 0.0 1.9 1 1 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 EWC46252.1 - 0.0019 17.6 0.0 0.0027 17.1 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Eno-Rase_NADH_b PF12242.3 EWC46252.1 - 0.022 14.5 0.0 0.048 13.4 0.0 1.6 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase RmlD_sub_bind PF04321.12 EWC46252.1 - 0.068 12.0 0.0 0.11 11.3 0.0 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain CMD PF02627.15 EWC46253.1 - 4.2e-05 23.2 0.0 9.4e-05 22.1 0.0 1.7 1 0 0 1 1 1 1 Carboxymuconolactone decarboxylase family adh_short_C2 PF13561.1 EWC46254.1 - 3.2e-21 76.1 0.1 3.7e-21 75.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 EWC46254.1 - 6.3e-12 45.7 0.2 1.3e-11 44.6 0.1 1.6 2 1 0 2 2 2 1 short chain dehydrogenase KAR9 PF08580.5 EWC46254.1 - 0.2 9.9 0.0 0.27 9.4 0.0 1.1 1 0 0 1 1 1 0 Yeast cortical protein KAR9 Glyco_transf_22 PF03901.12 EWC46256.1 - 5e-77 259.6 15.1 6.2e-77 259.3 10.5 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family Aminotran_5 PF00266.14 EWC46256.1 - 4.4e-46 157.2 0.0 7.3e-46 156.5 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.16 EWC46256.1 - 1.9e-09 36.9 0.0 3.1e-09 36.2 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.15 EWC46256.1 - 0.00011 20.6 0.0 0.00018 19.9 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme B12-binding PF02310.14 EWC46256.1 - 0.021 14.7 0.0 0.086 12.7 0.0 1.9 2 0 0 2 2 2 0 B12 binding domain Glyco_transf_20 PF00982.16 EWC46257.1 - 6.1e-161 536.0 0.0 1e-160 535.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.11 EWC46257.1 - 2.7e-42 144.2 0.1 4.1e-42 143.6 0.0 1.3 1 0 0 1 1 1 1 Trehalose-phosphatase DUF4250 PF14056.1 EWC46257.1 - 0.043 13.5 0.1 0.088 12.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4250) DUF3812 PF12757.2 EWC46258.1 - 4.1e-28 97.8 13.5 4.1e-28 97.8 9.4 4.2 5 0 0 5 5 5 1 Protein of unknown function (DUF3812) zf-C3HC4 PF00097.20 EWC46259.1 - 3.6e-09 36.1 11.2 3.6e-09 36.1 7.8 3.9 4 1 1 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EWC46259.1 - 2.1e-08 33.8 12.3 2.1e-08 33.8 8.5 4.1 4 1 1 5 5 5 1 Ring finger domain zf-C3HC4_2 PF13923.1 EWC46259.1 - 5.7e-08 32.6 12.7 5.7e-08 32.6 8.8 4.2 5 0 0 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EWC46259.1 - 1.5e-06 27.8 10.9 1.5e-06 27.8 7.6 3.5 4 1 0 4 4 4 1 zinc-RING finger domain zf-RING_6 PF14835.1 EWC46259.1 - 1.9e-05 24.3 8.2 1.9e-05 24.3 5.7 2.0 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-C3HC4_3 PF13920.1 EWC46259.1 - 2.7e-05 23.7 11.8 2.7e-05 23.7 8.2 4.1 5 0 0 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 EWC46259.1 - 5e-05 23.0 22.3 8.5e-05 22.3 8.9 3.7 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.2 EWC46259.1 - 0.0022 18.0 4.2 0.0022 18.0 2.9 3.1 2 1 0 2 2 2 1 RING-H2 zinc finger zf-Nse PF11789.3 EWC46259.1 - 0.04 13.4 4.9 0.14 11.7 3.4 1.9 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.1 EWC46259.1 - 0.13 12.0 9.5 0.35 10.6 6.2 2.1 2 0 0 2 2 2 0 RING-type zinc-finger SPOR PF05036.8 EWC46260.1 - 0.08 13.1 0.2 3 8.0 0.0 2.4 2 1 0 2 2 2 0 Sporulation related domain E1-E2_ATPase PF00122.15 EWC46262.1 - 4.2e-47 160.1 1.9 7.6e-47 159.2 1.3 1.4 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 EWC46262.1 - 1.5e-36 125.6 1.0 1.5e-36 125.6 0.7 2.9 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 EWC46262.1 - 3.9e-31 109.1 0.0 2e-30 106.7 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 EWC46262.1 - 4.8e-18 66.0 0.0 9.7e-18 65.0 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 EWC46262.1 - 2.5e-17 62.6 0.0 5.3e-17 61.5 0.0 1.6 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Cation_ATPase_N PF00690.21 EWC46262.1 - 2.7e-14 52.3 0.0 5.5e-14 51.3 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.7 EWC46262.1 - 8.1e-06 25.5 1.1 1.7e-05 24.5 0.7 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF2207 PF09972.4 EWC46262.1 - 0.0023 16.5 0.1 0.0051 15.4 0.0 1.5 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) CcmH PF03918.9 EWC46262.1 - 0.054 12.4 0.2 11 5.0 0.0 2.6 2 0 0 2 2 2 0 Cytochrome C biogenesis protein NfeD PF01957.13 EWC46262.1 - 0.68 10.0 6.6 0.18 11.9 0.9 2.5 2 0 0 2 2 2 0 NfeD-like C-terminal, partner-binding DUF4149 PF13664.1 EWC46262.1 - 0.7 9.9 9.2 1.2 9.1 0.2 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4149) DUF2231 PF09990.4 EWC46262.1 - 1.6 9.1 7.9 0.17 12.2 1.5 2.4 3 0 0 3 3 2 0 Predicted membrane protein (DUF2231) DUF1469 PF07332.6 EWC46262.1 - 3.1 7.5 12.8 0.27 10.9 1.9 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1469) Autophagy_act_C PF03987.10 EWC46264.1 - 7.8e-08 32.3 1.1 2.1e-07 31.0 0.7 1.8 1 1 0 1 1 1 1 Autophagocytosis associated protein, active-site domain LRR_8 PF13855.1 EWC46265.1 - 0.0025 17.5 7.9 0.077 12.7 0.0 4.8 4 1 1 5 5 5 1 Leucine rich repeat GATA PF00320.22 EWC46265.1 - 0.013 14.7 4.4 0.034 13.5 3.0 1.7 1 0 0 1 1 1 0 GATA zinc finger Pex14_N PF04695.8 EWC46265.1 - 0.034 14.1 0.3 0.069 13.1 0.2 1.5 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region TFIIF_alpha PF05793.7 EWC46265.1 - 0.034 12.5 20.5 0.05 11.9 14.2 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Ste50p-SAM PF09235.5 EWC46265.1 - 0.041 13.8 5.8 4.8 7.2 0.6 3.4 3 0 0 3 3 3 0 Ste50p, sterile alpha motif LRR_6 PF13516.1 EWC46265.1 - 0.057 13.5 12.4 61 4.1 0.1 7.4 8 0 0 8 8 8 0 Leucine Rich repeat LRR_1 PF00560.28 EWC46265.1 - 0.065 13.3 13.8 8 6.9 0.1 6.5 7 1 0 7 7 7 0 Leucine Rich Repeat LRR_7 PF13504.1 EWC46265.1 - 3.4 8.2 14.5 57 4.5 0.1 6.8 7 0 0 7 7 7 0 Leucine rich repeat PBP1_TM PF14812.1 EWC46266.1 - 0.051 13.8 0.3 0.051 13.8 0.2 3.6 3 1 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal SNF2_N PF00176.18 EWC46267.1 - 2.2e-72 243.3 0.0 2.9e-72 242.9 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain DEAD PF00270.24 EWC46267.1 - 1.1e-09 38.0 0.0 2.2e-09 37.0 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EWC46267.1 - 2.7e-09 36.7 0.0 5.8e-09 35.6 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-C3HC4 PF00097.20 EWC46267.1 - 4.9e-06 26.0 8.1 4.9e-06 26.0 5.6 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 EWC46267.1 - 0.00015 21.6 9.0 0.00015 21.6 6.2 2.6 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 EWC46267.1 - 0.00029 20.4 7.9 0.00029 20.4 5.5 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EWC46267.1 - 0.00042 20.0 8.7 0.00042 20.0 6.0 2.4 2 0 0 2 2 2 1 Ring finger domain zf-RING_UBOX PF13445.1 EWC46267.1 - 0.0079 15.8 2.8 0.022 14.4 2.0 1.8 1 0 0 1 1 1 1 RING-type zinc-finger Zn_Tnp_IS91 PF14319.1 EWC46267.1 - 0.24 10.9 15.2 0.81 9.2 1.5 2.8 2 0 0 2 2 2 0 Transposase zinc-binding domain WW PF00397.21 EWC46268.1 - 4.7e-08 32.7 0.2 4.7e-08 32.7 0.2 2.3 2 0 0 2 2 2 1 WW domain WD40 PF00400.27 EWC46269.1 - 4.4e-18 64.4 9.8 5.1e-07 29.3 0.0 6.4 6 0 0 6 6 6 4 WD domain, G-beta repeat Rax2 PF12768.2 EWC46269.1 - 0.017 14.3 0.0 0.049 12.8 0.0 1.7 2 0 0 2 2 2 0 Cortical protein marker for cell polarity UCH PF00443.24 EWC46270.1 - 5.1e-29 101.2 0.0 8.2e-29 100.5 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.14 EWC46270.1 - 3.9e-13 49.3 0.4 8.9e-13 48.1 0.3 1.6 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein AAA PF00004.24 EWC46272.1 - 2.6e-12 47.0 0.1 1.1e-11 44.9 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 EWC46272.1 - 1.3e-11 44.7 0.1 3.6e-10 40.1 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 EWC46272.1 - 1.3e-10 41.5 0.0 3.1e-10 40.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.1 EWC46272.1 - 0.00018 20.9 2.2 0.049 13.0 0.0 3.2 4 0 0 4 4 4 2 AAA domain Arch_ATPase PF01637.13 EWC46272.1 - 0.00032 20.4 0.0 0.0021 17.8 0.0 2.1 1 1 0 1 1 1 1 Archaeal ATPase AAA_19 PF13245.1 EWC46272.1 - 0.00048 19.8 0.1 0.0021 17.7 0.1 2.2 1 0 0 1 1 1 1 Part of AAA domain Cdc6_C PF09079.6 EWC46272.1 - 0.0011 18.7 0.0 0.0034 17.0 0.0 2.0 1 1 0 1 1 1 1 CDC6, C terminal AAA_30 PF13604.1 EWC46272.1 - 0.0028 17.2 0.1 0.009 15.6 0.1 1.8 1 1 0 1 1 1 1 AAA domain DUF2075 PF09848.4 EWC46272.1 - 0.0083 15.1 0.0 0.013 14.4 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) DAP3 PF10236.4 EWC46272.1 - 0.012 14.5 0.0 0.026 13.4 0.0 1.5 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 MMR_HSR1 PF01926.18 EWC46272.1 - 0.027 14.4 0.1 0.091 12.7 0.0 1.9 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_11 PF13086.1 EWC46272.1 - 0.045 13.3 0.0 0.074 12.6 0.0 1.5 1 1 0 1 1 1 0 AAA domain NACHT PF05729.7 EWC46272.1 - 0.053 13.1 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 NACHT domain PIF1 PF05970.9 EWC46272.1 - 0.074 11.9 0.0 0.12 11.2 0.0 1.2 1 0 0 1 1 1 0 PIF1-like helicase AAA_14 PF13173.1 EWC46272.1 - 0.091 12.6 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.12 EWC46272.1 - 0.1 12.0 0.2 0.52 9.7 0.0 2.0 2 0 0 2 2 2 0 IstB-like ATP binding protein RNA_helicase PF00910.17 EWC46272.1 - 0.12 12.5 0.0 0.26 11.4 0.0 1.5 1 0 0 1 1 1 0 RNA helicase RNA12 PF10443.4 EWC46272.1 - 0.14 10.6 0.0 0.5 8.7 0.0 1.9 2 0 0 2 2 2 0 RNA12 protein TIP49 PF06068.8 EWC46272.1 - 0.14 10.8 0.1 0.23 10.1 0.0 1.3 1 0 0 1 1 1 0 TIP49 C-terminus AMP-binding PF00501.23 EWC46274.1 - 6.6e-70 235.6 0.0 8.3e-70 235.2 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 EWC46274.1 - 2e-13 51.0 0.2 7.8e-13 49.1 0.3 1.9 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Proteasome PF00227.21 EWC46275.1 - 1.4e-38 132.0 0.0 1.7e-38 131.8 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit WD40 PF00400.27 EWC46276.1 - 3.4e-72 235.9 19.5 2.9e-08 33.2 0.1 12.2 12 0 0 12 12 12 11 WD domain, G-beta repeat Utp13 PF08625.6 EWC46276.1 - 3.3e-38 130.5 0.0 5.2e-38 129.8 0.0 1.3 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain Nup160 PF11715.3 EWC46276.1 - 6.8e-06 24.4 0.6 0.27 9.3 0.0 3.9 4 1 0 4 4 4 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 EWC46276.1 - 2.2e-05 23.3 0.1 0.57 8.8 0.0 4.7 4 1 0 4 4 4 2 Nup133 N terminal like CobT PF06213.7 EWC46276.1 - 6 5.9 12.7 10 5.1 0.1 2.2 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT DUF1688 PF07958.6 EWC46277.1 - 2.7e-160 533.4 0.0 3.1e-160 533.3 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1688) TUG-UBL1 PF11470.3 EWC46278.1 - 1e-20 73.3 0.1 2.7e-20 72.0 0.1 1.7 1 0 0 1 1 1 1 GLUT4 regulating protein TUG UBX PF00789.15 EWC46278.1 - 3.5e-08 33.3 0.0 5e-07 29.6 0.0 2.7 2 1 0 2 2 2 1 UBX domain RBD PF02196.10 EWC46278.1 - 0.00037 20.1 0.0 0.00073 19.2 0.0 1.4 1 0 0 1 1 1 1 Raf-like Ras-binding domain Rad60-SLD PF11976.3 EWC46278.1 - 0.086 12.5 0.0 0.27 10.9 0.0 1.8 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like HlyIII PF03006.15 EWC46279.1 - 9.1e-56 188.7 19.1 1.1e-55 188.4 13.3 1.1 1 0 0 1 1 1 1 Haemolysin-III related DUF3493 PF11998.3 EWC46279.1 - 0.016 15.0 0.4 0.059 13.2 0.3 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3493) DivIVA PF05103.8 EWC46279.1 - 0.96 9.4 4.7 3.4 7.7 0.1 2.2 1 1 1 2 2 2 0 DivIVA protein FCH PF00611.18 EWC46280.1 - 7.9e-14 51.6 0.2 9.7e-13 48.1 0.0 2.4 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain RhoGAP PF00620.22 EWC46280.1 - 1.6e-13 50.5 0.0 4.2e-13 49.1 0.0 1.7 1 0 0 1 1 1 1 RhoGAP domain DEP PF00610.16 EWC46280.1 - 2.7e-10 39.8 0.0 7.1e-10 38.4 0.0 1.8 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) DUF869 PF05911.6 EWC46280.1 - 0.064 11.4 2.0 0.11 10.7 1.4 1.2 1 0 0 1 1 1 0 Plant protein of unknown function (DUF869) SMAP PF15477.1 EWC46281.1 - 3e-12 46.6 4.8 3e-12 46.6 3.3 6.0 5 3 0 5 5 5 1 Small acidic protein family Peptidase_M16_C PF05193.16 EWC46282.1 - 4.1e-19 68.9 0.0 1.7e-12 47.4 0.0 3.2 2 1 0 2 2 2 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.15 EWC46282.1 - 0.0001 22.0 0.1 0.0014 18.4 0.0 2.6 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) DNA_pol_E_B PF04042.11 EWC46283.1 - 6.2e-47 159.5 0.0 1e-46 158.8 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Zw10 PF06248.8 EWC46283.1 - 2.7e-20 72.1 0.0 1.1e-16 60.1 0.0 2.1 2 0 0 2 2 2 2 Centromere/kinetochore Zw10 Dsl1_C PF11989.3 EWC46283.1 - 0.026 13.7 3.1 0.055 12.6 0.0 2.5 3 0 0 3 3 3 0 Retrograde transport protein Dsl1 C terminal SNF2_N PF00176.18 EWC46284.1 - 7.1e-55 185.9 0.0 1.2e-54 185.1 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain zf-RING_2 PF13639.1 EWC46284.1 - 1.2e-07 31.4 10.3 3e-07 30.1 7.1 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 EWC46284.1 - 7.3e-07 28.7 9.2 1.5e-06 27.7 6.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 EWC46284.1 - 7.9e-07 28.6 8.5 1.6e-06 27.6 5.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 EWC46284.1 - 2.5e-06 27.4 11.0 5.6e-06 26.2 7.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 EWC46284.1 - 3.6e-06 26.9 4.2 1.2e-05 25.3 2.9 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_5 PF14634.1 EWC46284.1 - 1.5e-05 24.6 8.0 2.8e-05 23.7 5.6 1.5 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.1 EWC46284.1 - 0.00024 20.5 3.7 0.00053 19.4 2.5 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 Cript PF10235.4 EWC46284.1 - 0.0055 17.0 0.8 0.012 15.9 0.5 1.5 1 0 0 1 1 1 1 Microtubule-associated protein CRIPT Helicase_C PF00271.26 EWC46284.1 - 0.012 15.4 0.0 0.032 14.1 0.0 1.7 1 0 0 1 1 1 0 Helicase conserved C-terminal domain DZR PF12773.2 EWC46284.1 - 0.63 9.8 4.2 1.6 8.6 2.9 1.6 1 0 0 1 1 1 0 Double zinc ribbon zf-RING_UBOX PF13445.1 EWC46284.1 - 1.2 8.9 7.4 2.9 7.6 5.1 1.6 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_4 PF15227.1 EWC46284.1 - 5 7.0 9.5 10 6.0 6.6 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING RAMP4 PF06624.7 EWC46285.1 - 8.9e-06 25.1 0.0 9.5e-06 25.0 0.0 1.1 1 0 0 1 1 1 1 Ribosome associated membrane protein RAMP4 Polyketide_cyc PF03364.15 EWC46286.1 - 3.1e-21 75.7 0.0 4e-21 75.3 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc2 PF10604.4 EWC46286.1 - 5e-07 29.9 1.2 3.4e-06 27.2 0.8 2.0 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport BatA PF07584.6 EWC46287.1 - 0.0045 17.1 0.5 0.072 13.2 0.0 2.2 2 0 0 2 2 2 1 Aerotolerance regulator N-terminal SKG6 PF08693.5 EWC46287.1 - 0.022 14.0 0.1 0.047 13.0 0.1 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Mid2 PF04478.7 EWC46287.1 - 0.024 14.0 0.3 0.024 14.0 0.2 1.6 1 1 1 2 2 2 0 Mid2 like cell wall stress sensor Lamp PF01299.12 EWC46287.1 - 1.2 8.2 6.7 4.6 6.2 0.0 2.4 2 0 0 2 2 2 0 Lysosome-associated membrane glycoprotein (Lamp) Taxilin PF09728.4 EWC46288.1 - 6.5e-92 307.9 63.5 8.6e-92 307.5 44.0 1.2 1 0 0 1 1 1 1 Myosin-like coiled-coil protein MSP PF01716.13 EWC46288.1 - 0.54 9.2 5.6 0.76 8.7 1.1 2.4 2 0 0 2 2 2 0 Manganese-stabilising protein / photosystem II polypeptide Na_H_Exchanger PF00999.16 EWC46290.1 - 8.2e-39 133.1 26.1 2.2e-34 118.6 15.9 2.0 2 0 0 2 2 2 2 Sodium/hydrogen exchanger family M16C_assoc PF08367.6 EWC46291.1 - 3.2e-65 219.4 0.0 5.3e-65 218.7 0.0 1.4 1 0 0 1 1 1 1 Peptidase M16C associated Peptidase_M16_C PF05193.16 EWC46291.1 - 1.2e-35 122.9 0.4 8.1e-22 77.7 0.0 3.2 5 0 0 5 5 5 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.15 EWC46291.1 - 8.6e-13 48.2 0.0 3.1e-11 43.2 0.0 2.8 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) F-box-like PF12937.2 EWC46292.1 - 0.0016 18.1 0.0 0.0035 17.0 0.0 1.7 1 0 0 1 1 1 1 F-box-like Formyl_trans_N PF00551.14 EWC46293.1 - 2.3e-42 144.5 0.0 3e-42 144.2 0.0 1.1 1 0 0 1 1 1 1 Formyl transferase Ribosomal_L36e PF01158.13 EWC46294.1 - 2.2e-39 133.3 7.3 2.5e-39 133.2 5.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L36e LemA PF04011.7 EWC46294.1 - 0.059 12.4 0.2 0.062 12.4 0.1 1.1 1 0 0 1 1 1 0 LemA family 4HB_MCP_1 PF12729.2 EWC46294.1 - 0.11 11.8 0.0 0.12 11.6 0.0 1.1 1 0 0 1 1 1 0 Four helix bundle sensory module for signal transduction Ribosomal_L38e PF01781.13 EWC46295.1 - 5.5e-32 109.3 0.8 6.2e-32 109.1 0.6 1.0 1 0 0 1 1 1 1 Ribosomal L38e protein family Acetyltransf_3 PF13302.1 EWC46296.1 - 8.4e-17 61.6 0.0 1.2e-16 61.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 EWC46296.1 - 0.0021 18.0 0.1 0.02 14.8 0.1 2.1 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.5 EWC46296.1 - 0.046 13.4 0.1 1.1 9.0 0.0 2.2 1 1 1 2 2 2 0 FR47-like protein Ipi1_N PF12333.3 EWC46298.1 - 1.2e-24 86.2 0.0 5.5e-24 84.0 0.0 2.1 2 1 0 2 2 2 1 Rix1 complex component involved in 60S ribosome maturation NACHT PF05729.7 EWC46299.1 - 4.8e-09 36.1 0.3 1.5e-08 34.4 0.0 2.0 2 0 0 2 2 2 1 NACHT domain AAA_22 PF13401.1 EWC46299.1 - 0.0027 17.8 0.0 0.043 13.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain Ank_2 PF12796.2 EWC46299.1 - 0.0034 17.6 0.0 0.015 15.5 0.0 2.1 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.1 EWC46299.1 - 0.2 11.9 1.1 8.1 7.0 0.0 3.9 4 0 0 4 4 4 0 Ankyrin repeat BAR_2 PF10455.4 EWC46300.1 - 4.8e-51 173.3 0.0 1e-50 172.3 0.0 1.5 1 1 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR PF03114.13 EWC46300.1 - 1.5e-11 44.2 0.1 1.8e-10 40.7 0.0 2.5 2 1 0 2 2 2 1 BAR domain AMP-binding PF00501.23 EWC46301.1 - 5.9e-15 54.5 0.1 5.4e-07 28.3 0.0 2.3 2 0 0 2 2 2 2 AMP-binding enzyme Dopey_N PF04118.9 EWC46302.1 - 0.038 12.7 0.4 0.12 11.0 0.1 1.8 2 0 0 2 2 2 0 Dopey, N-terminal PLAC8 PF04749.12 EWC46302.1 - 0.23 12.0 2.1 0.82 10.2 0.0 2.7 2 1 0 2 2 2 0 PLAC8 family Cadherin_C PF01049.12 EWC46303.1 - 0.72 9.8 6.0 0.33 10.9 2.0 2.0 2 0 0 2 2 2 0 Cadherin cytoplasmic region p450 PF00067.17 EWC46304.1 - 7.1e-51 173.1 0.0 1.3e-50 172.3 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 WD40 PF00400.27 EWC46305.1 - 2.2e-06 27.3 4.9 0.01 15.7 0.0 5.5 6 0 0 6 6 6 1 WD domain, G-beta repeat CDC45 PF02724.9 EWC46305.1 - 0.0011 17.0 8.8 0.0015 16.6 6.1 1.1 1 0 0 1 1 1 1 CDC45-like protein SGT1 PF07093.6 EWC46305.1 - 0.0024 16.3 1.1 0.0027 16.1 0.7 1.1 1 0 0 1 1 1 1 SGT1 protein TLP-20 PF06088.6 EWC46305.1 - 0.019 14.6 1.9 0.033 13.8 1.3 1.4 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) BUD22 PF09073.5 EWC46305.1 - 0.02 13.9 16.8 0.029 13.4 11.7 1.1 1 0 0 1 1 1 0 BUD22 PQQ_2 PF13360.1 EWC46305.1 - 0.029 13.8 0.6 0.42 10.0 0.4 2.3 1 1 0 1 1 1 0 PQQ-like domain PQQ_3 PF13570.1 EWC46305.1 - 0.087 13.1 5.1 17 5.8 0.1 5.0 4 1 0 4 4 4 0 PQQ-like domain SDA1 PF05285.7 EWC46305.1 - 0.11 11.7 15.9 0.15 11.2 11.0 1.1 1 0 0 1 1 1 0 SDA1 DUF2457 PF10446.4 EWC46305.1 - 0.11 11.2 18.9 0.2 10.3 13.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Nop14 PF04147.7 EWC46305.1 - 0.25 9.1 15.2 0.34 8.7 10.6 1.1 1 0 0 1 1 1 0 Nop14-like family TFIIF_alpha PF05793.7 EWC46305.1 - 0.42 8.9 15.3 0.62 8.3 10.6 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Sigma70_ner PF04546.8 EWC46305.1 - 0.51 9.9 9.8 0.75 9.3 6.8 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region Nucleoplasmin PF03066.10 EWC46305.1 - 1.1 8.7 13.5 2.3 7.7 9.3 1.4 1 0 0 1 1 1 0 Nucleoplasmin DUF2890 PF11081.3 EWC46305.1 - 1.3 8.9 11.7 2.3 8.2 8.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) Herpes_DNAp_acc PF04929.7 EWC46305.1 - 1.4 7.7 7.6 2.1 7.2 5.3 1.1 1 0 0 1 1 1 0 Herpes DNA replication accessory factor NOA36 PF06524.7 EWC46305.1 - 1.8 7.7 11.5 3 7.0 8.0 1.3 1 0 0 1 1 1 0 NOA36 protein CENP-B_dimeris PF09026.5 EWC46305.1 - 7.7 6.8 16.3 20 5.4 11.3 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Diphthamide_syn PF01866.12 EWC46306.1 - 3.7e-47 161.0 0.0 6.7e-47 160.2 0.0 1.3 1 0 0 1 1 1 1 Putative diphthamide synthesis protein Es2 PF09751.4 EWC46307.1 - 2.2e-94 317.2 1.4 2.6e-94 316.9 1.0 1.0 1 0 0 1 1 1 1 Nuclear protein Es2 AMP-binding PF00501.23 EWC46308.1 - 6e-64 215.9 0.1 9.3e-64 215.3 0.1 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 EWC46308.1 - 9.2e-07 29.7 0.4 2.6e-06 28.2 0.2 2.0 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain DIE2_ALG10 PF04922.7 EWC46309.1 - 3.1e-76 256.8 26.9 1e-55 189.3 14.7 2.6 2 2 0 2 2 2 2 DIE2/ALG10 family DDE_Tnp_1_assoc PF13808.1 EWC46310.1 - 0.16 11.6 0.0 0.27 10.9 0.0 1.3 1 0 0 1 1 1 0 DDE_Tnp_1-associated CcoS PF03597.10 EWC46310.1 - 1.2 8.7 5.5 1.9 8.0 3.8 1.3 1 0 0 1 1 1 0 Cytochrome oxidase maturation protein cbb3-type Bromo_TP PF07524.8 EWC46311.1 - 1.7e-09 37.2 0.0 3e-09 36.4 0.0 1.4 1 0 0 1 1 1 1 Bromodomain associated TAF8_C PF10406.4 EWC46311.1 - 3.7e-09 36.4 0.6 3.7e-09 36.4 0.4 2.2 2 0 0 2 2 2 1 Transcription factor TFIID complex subunit 8 C-term TAF PF02969.12 EWC46311.1 - 0.00083 19.2 0.0 0.0028 17.5 0.0 1.9 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) Sld5 PF05916.6 EWC46312.1 - 8.7e-07 29.2 0.1 1.6e-06 28.3 0.0 1.4 1 0 0 1 1 1 1 GINS complex protein Pyridoxal_deC PF00282.14 EWC46313.1 - 2.9e-112 374.8 0.0 3.8e-112 374.4 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain cwf21 PF08312.7 EWC46313.1 - 0.15 11.8 0.2 0.57 10.0 0.0 1.9 2 0 0 2 2 2 0 cwf21 domain CENP-L PF13092.1 EWC46313.1 - 0.18 11.5 0.0 0.32 10.7 0.0 1.3 1 0 0 1 1 1 0 Kinetochore complex Sim4 subunit Fta1 Rad51 PF08423.6 EWC46315.1 - 0.00036 19.5 0.0 0.013 14.3 0.0 2.2 2 0 0 2 2 2 2 Rad51 AAA_25 PF13481.1 EWC46315.1 - 0.00093 18.6 0.0 0.0028 17.1 0.0 1.9 2 0 0 2 2 2 1 AAA domain DUF3287 PF11690.3 EWC46316.1 - 0.14 12.2 1.6 0.17 11.9 1.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3287) Ank_2 PF12796.2 EWC46317.1 - 4.3e-20 71.8 0.8 3.2e-10 40.2 0.2 3.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 EWC46317.1 - 3.5e-19 67.5 3.5 2e-05 24.1 0.0 5.5 5 0 0 5 5 5 5 Ankyrin repeat Ank_3 PF13606.1 EWC46317.1 - 3.3e-14 51.5 1.6 0.0023 18.0 0.0 5.9 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.1 EWC46317.1 - 2e-11 43.7 0.8 0.0004 20.5 0.0 4.5 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.1 EWC46317.1 - 5e-11 42.8 3.1 3.2e-05 24.3 0.0 4.8 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Apc3 PF12895.2 EWC46317.1 - 0.017 15.2 1.6 0.032 14.3 0.3 2.0 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.12 EWC46317.1 - 0.017 14.9 2.4 0.17 11.8 0.4 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.23 EWC46317.1 - 0.021 14.3 0.3 0.068 12.8 0.2 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_11 PF13414.1 EWC46317.1 - 0.085 12.5 1.2 0.23 11.1 0.3 2.0 2 0 0 2 2 2 0 TPR repeat Fis1_TPR_C PF14853.1 EWC46317.1 - 0.44 10.4 4.5 0.34 10.8 0.9 2.2 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat AJAP1_PANP_C PF15298.1 EWC46318.1 - 0.0026 17.6 13.0 0.0026 17.6 9.0 1.4 1 1 0 1 1 1 1 AJAP1/PANP C-terminus Herpes_BLLF1 PF05109.8 EWC46318.1 - 0.16 9.8 25.0 0.21 9.5 17.3 1.1 1 0 0 1 1 1 0 Herpes virus major outer envelope glycoprotein (BLLF1) Macoilin PF09726.4 EWC46318.1 - 0.45 8.7 3.8 0.47 8.6 2.6 1.1 1 0 0 1 1 1 0 Transmembrane protein eRF1_1 PF03463.10 EWC46320.1 - 2.2e-48 163.1 0.3 5e-48 162.0 0.0 1.7 2 0 0 2 2 2 1 eRF1 domain 1 eRF1_2 PF03464.10 EWC46320.1 - 3.7e-28 98.4 0.0 5.9e-28 97.8 0.0 1.3 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.10 EWC46320.1 - 4.1e-21 75.3 0.1 1e-20 74.0 0.0 1.7 2 0 0 2 2 2 1 eRF1 domain 3 ATP_bind_4 PF01902.12 EWC46321.1 - 2.8e-30 105.3 0.1 2.4e-28 98.9 0.1 2.3 1 1 0 1 1 1 1 ATP-binding region Ribonuc_L-PSP PF01042.16 EWC46321.1 - 4.5e-18 65.1 0.0 7.2e-08 32.2 0.0 3.4 3 0 0 3 3 3 3 Endoribonuclease L-PSP Asp PF00026.18 EWC46322.1 - 1.2e-13 51.0 0.0 2.9e-13 49.7 0.0 1.6 1 1 0 1 1 1 1 Eukaryotic aspartyl protease Glyco_hydro_45 PF02015.11 EWC46324.1 - 1.6e-55 188.3 7.3 1.9e-55 188.0 5.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 45 Thioredoxin PF00085.15 EWC46325.1 - 6.4e-34 115.7 0.0 8.9e-28 96.0 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_2 PF13098.1 EWC46325.1 - 2.6e-07 30.8 2.9 0.0015 18.6 0.1 3.1 3 1 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_8 PF13905.1 EWC46325.1 - 0.00021 21.3 0.0 0.058 13.5 0.0 3.4 2 2 1 3 3 3 1 Thioredoxin-like AhpC-TSA PF00578.16 EWC46325.1 - 0.022 14.4 0.0 0.23 11.1 0.0 2.4 2 0 0 2 2 2 0 AhpC/TSA family HyaE PF07449.6 EWC46325.1 - 0.036 13.9 0.0 0.22 11.4 0.0 2.3 2 1 0 2 2 2 0 Hydrogenase-1 expression protein HyaE Thioredoxin_7 PF13899.1 EWC46325.1 - 0.062 13.3 0.0 0.19 11.7 0.0 1.8 2 0 0 2 2 2 0 Thioredoxin-like Thioredoxin_3 PF13192.1 EWC46325.1 - 0.089 12.6 0.0 0.26 11.1 0.0 1.8 2 0 0 2 2 2 0 Thioredoxin domain RR_TM4-6 PF06459.7 EWC46325.1 - 1.2 9.0 8.4 2.2 8.1 5.8 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF846 PF05832.7 EWC46326.1 - 7.5e-49 165.0 6.2 8.9e-49 164.8 4.3 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) DUF3704 PF12488.3 EWC46326.1 - 0.044 13.3 0.3 11 5.7 0.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3704) eIF-3_zeta PF05091.7 EWC46327.1 - 9.3e-187 621.7 0.0 1.1e-186 621.4 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) ChaC PF04752.7 EWC46328.1 - 7.3e-34 117.2 0.2 3.6e-33 115.0 0.1 1.7 1 1 0 1 1 1 1 ChaC-like protein AIG2 PF06094.7 EWC46328.1 - 0.015 15.7 0.0 0.024 15.1 0.0 1.3 1 0 0 1 1 1 0 AIG2-like family RRM_1 PF00076.17 EWC46329.1 - 2e-23 81.8 0.1 2.5e-23 81.4 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EWC46329.1 - 2.8e-17 62.4 0.1 3.5e-17 62.1 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EWC46329.1 - 1.1e-09 37.9 0.0 1.4e-09 37.6 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) EF-hand_1 PF00036.27 EWC46330.1 - 2.7e-30 101.3 1.9 3e-07 29.2 0.1 5.2 5 0 0 5 5 5 4 EF hand EF-hand_7 PF13499.1 EWC46330.1 - 1.2e-25 89.4 0.4 1.5e-10 41.0 0.0 3.3 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.1 EWC46330.1 - 3.1e-25 87.5 4.5 3.3e-09 36.2 0.2 5.1 2 2 3 5 5 5 5 EF-hand domain pair EF-hand_6 PF13405.1 EWC46330.1 - 5.2e-24 81.9 3.4 8.4e-05 22.1 0.0 5.2 5 0 0 5 5 5 4 EF-hand domain EF-hand_5 PF13202.1 EWC46330.1 - 8.4e-22 75.4 0.7 5.5e-05 22.3 0.0 4.4 4 0 0 4 4 4 4 EF hand SPARC_Ca_bdg PF10591.4 EWC46330.1 - 0.079 12.9 0.0 6.2 6.8 0.0 3.1 2 1 1 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 EWC46330.1 - 0.1 12.3 0.3 1.4 8.7 0.0 2.5 2 1 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand Pkinase PF00069.20 EWC46332.1 - 4.1e-65 219.5 0.0 5.8e-65 219.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC46332.1 - 7.1e-29 100.6 0.0 1.1e-28 100.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.21 EWC46332.1 - 6.9e-15 54.9 0.1 1.9e-08 34.2 0.0 2.7 2 0 0 2 2 2 2 FHA domain Kinase-like PF14531.1 EWC46332.1 - 1.8e-05 23.8 0.0 4.4e-05 22.5 0.0 1.6 2 0 0 2 2 2 1 Kinase-like OspD PF03207.8 EWC46332.1 - 0.00046 19.4 0.2 0.00079 18.6 0.1 1.3 1 0 0 1 1 1 1 Borrelia outer surface protein D (OspD) Kdo PF06293.9 EWC46332.1 - 0.0021 17.1 0.0 0.0041 16.2 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.6 EWC46332.1 - 0.13 11.0 0.1 0.2 10.4 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Ribul_P_3_epim PF00834.14 EWC46333.1 - 1.4e-67 226.6 0.0 1.7e-67 226.4 0.0 1.0 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family ThiG PF05690.9 EWC46333.1 - 0.00029 19.9 0.2 0.00039 19.5 0.1 1.1 1 0 0 1 1 1 1 Thiazole biosynthesis protein ThiG OMPdecase PF00215.19 EWC46333.1 - 0.049 13.0 0.1 0.078 12.3 0.1 1.3 1 0 0 1 1 1 0 Orotidine 5'-phosphate decarboxylase / HUMPS family QRPTase_C PF01729.14 EWC46333.1 - 0.092 12.2 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 Quinolinate phosphoribosyl transferase, C-terminal domain PG_binding_3 PF09374.5 EWC46333.1 - 0.11 12.5 0.1 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 Predicted Peptidoglycan domain Methyltransf_11 PF08241.7 EWC46335.1 - 7.3e-06 26.3 0.0 0.11 13.0 0.0 2.7 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_23 PF13489.1 EWC46335.1 - 0.02 14.6 0.0 0.048 13.3 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain TPR_11 PF13414.1 EWC46336.1 - 1.4e-26 91.9 8.1 6e-12 45.0 0.5 4.4 2 2 2 4 4 4 4 TPR repeat TPR_1 PF00515.23 EWC46336.1 - 3.8e-25 86.4 6.7 2.3e-09 36.4 0.0 5.6 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.12 EWC46336.1 - 5.9e-24 82.0 5.8 1.2e-07 31.0 0.0 5.9 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_16 PF13432.1 EWC46336.1 - 1.2e-17 64.0 9.1 1.3e-06 28.8 0.1 4.9 3 2 2 5 5 4 4 Tetratricopeptide repeat TPR_17 PF13431.1 EWC46336.1 - 1e-16 59.6 4.2 9.3e-05 22.3 0.1 5.4 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.1 EWC46336.1 - 4.1e-16 58.0 5.9 3.2e-05 24.1 0.0 5.8 2 2 3 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.1 EWC46336.1 - 6.6e-14 52.0 5.7 3.6e-05 24.0 0.1 4.4 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.1 EWC46336.1 - 6.6e-13 48.3 6.9 1e-07 31.7 0.1 4.1 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.1 EWC46336.1 - 9.1e-13 46.9 0.3 3.1e-05 23.4 0.0 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_9 PF13371.1 EWC46336.1 - 1.9e-10 40.4 2.3 0.00026 20.8 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_20 PF14561.1 EWC46336.1 - 2.4e-10 40.3 0.4 0.0053 16.8 0.0 4.3 2 2 1 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.1 EWC46336.1 - 3.6e-09 35.7 5.5 0.00057 19.4 0.0 5.5 5 1 1 6 6 6 1 Tetratricopeptide repeat Apc3 PF12895.2 EWC46336.1 - 7.7e-08 32.3 0.9 2.5e-05 24.3 0.1 2.6 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.1 EWC46336.1 - 4.8e-05 23.5 2.0 1.7 9.2 0.0 5.3 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_15 PF13429.1 EWC46336.1 - 4.8e-05 22.5 0.7 0.14 11.2 0.0 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_3 PF07720.7 EWC46336.1 - 0.002 17.8 0.0 2.8 7.8 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.1 EWC46336.1 - 0.0037 17.1 0.9 0.42 10.6 0.1 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat MIT PF04212.13 EWC46336.1 - 0.0076 16.1 2.5 1.4 8.8 0.1 4.2 3 1 0 3 3 3 1 MIT (microtubule interacting and transport) domain TOM20_plant PF06552.7 EWC46336.1 - 0.041 13.4 0.2 8.1 5.9 0.0 3.2 4 0 0 4 4 3 0 Plant specific mitochondrial import receptor subunit TOM20 TPR_5 PF12688.2 EWC46336.1 - 0.066 13.2 0.5 0.62 10.1 0.0 2.6 2 0 0 2 2 2 0 Tetratrico peptide repeat BTAD PF03704.12 EWC46336.1 - 0.07 13.4 2.1 10 6.3 0.0 3.3 3 0 0 3 3 3 0 Bacterial transcriptional activator domain Fis1_TPR_C PF14853.1 EWC46336.1 - 0.21 11.5 2.3 9.8 6.1 0.1 3.5 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat PDGF_N PF04692.8 EWC46337.1 - 1.4 9.4 7.6 0.88 10.1 0.2 2.5 2 0 0 2 2 2 0 Platelet-derived growth factor, N terminal region PAT1 PF09770.4 EWC46337.1 - 2.2 6.4 10.3 3.5 5.7 7.2 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Bestrophin PF01062.16 EWC46338.1 - 1.4e-29 103.0 0.1 7.4e-16 57.9 0.0 2.1 2 0 0 2 2 2 2 Bestrophin, RFP-TM, chloride channel PgaD PF13994.1 EWC46338.1 - 4.8 6.6 7.2 0.81 9.1 0.2 2.2 2 0 0 2 2 2 0 PgaD-like protein GalP_UDP_transf PF01087.17 EWC46339.1 - 3.9e-68 229.1 0.0 6.7e-68 228.3 0.0 1.3 1 0 0 1 1 1 1 Galactose-1-phosphate uridyl transferase, N-terminal domain GalP_UDP_tr_C PF02744.12 EWC46339.1 - 9e-53 178.2 0.0 1.5e-52 177.5 0.0 1.3 1 0 0 1 1 1 1 Galactose-1-phosphate uridyl transferase, C-terminal domain HIT PF01230.18 EWC46339.1 - 6e-06 26.7 0.0 0.018 15.5 0.0 2.4 2 0 0 2 2 2 2 HIT domain HLH PF00010.21 EWC46340.1 - 1.5e-13 50.1 1.7 2e-13 49.8 0.1 2.1 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain Phage_GPO PF05929.6 EWC46340.1 - 0.0018 17.5 0.2 0.0028 16.9 0.2 1.2 1 0 0 1 1 1 1 Phage capsid scaffolding protein (GPO) serine peptidase SLX9 PF15341.1 EWC46340.1 - 0.0055 17.1 1.0 0.014 15.8 0.7 1.6 1 0 0 1 1 1 1 Ribosome biogenesis protein SLX9 DUF972 PF06156.8 EWC46340.1 - 0.011 16.1 1.4 0.029 14.7 0.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF972) OmpH PF03938.9 EWC46340.1 - 0.017 15.0 0.5 0.038 13.9 0.2 1.6 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Tup_N PF08581.5 EWC46340.1 - 0.2 11.8 2.6 0.35 11.0 1.8 1.4 1 0 0 1 1 1 0 Tup N-terminal DUF904 PF06005.7 EWC46340.1 - 0.2 11.9 4.8 0.44 10.8 3.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF904) Rootletin PF15035.1 EWC46340.1 - 0.22 11.4 14.9 1.2 9.1 10.3 1.9 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion DUF724 PF05266.9 EWC46340.1 - 0.26 10.9 4.1 0.43 10.1 2.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) HALZ PF02183.13 EWC46340.1 - 0.41 10.3 3.3 0.64 9.7 1.3 1.9 1 1 1 2 2 2 0 Homeobox associated leucine zipper Fez1 PF06818.10 EWC46340.1 - 0.73 9.8 8.9 1.6 8.7 6.1 1.5 1 1 0 1 1 1 0 Fez1 IncA PF04156.9 EWC46340.1 - 4 6.9 6.3 9.2 5.8 4.4 1.5 1 1 0 1 1 1 0 IncA protein His_Phos_2 PF00328.17 EWC46342.1 - 5e-15 55.6 0.1 9.8e-14 51.4 0.1 2.0 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) P22_AR_C PF10548.4 EWC46342.1 - 0.024 14.4 0.0 0.049 13.5 0.0 1.4 1 0 0 1 1 1 0 P22AR C-terminal domain NDUFB10 PF10249.4 EWC46343.1 - 0.0072 16.4 0.0 0.0074 16.4 0.0 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit 10 HWE_HK PF07536.9 EWC46343.1 - 0.021 15.2 0.0 0.033 14.6 0.0 1.2 1 0 0 1 1 1 0 HWE histidine kinase Beta_elim_lyase PF01212.16 EWC46344.1 - 1.2e-68 231.3 0.0 1.5e-68 231.0 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.16 EWC46344.1 - 0.00014 20.9 0.0 0.00024 20.1 0.0 1.4 1 1 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.15 EWC46344.1 - 0.0037 15.6 0.0 0.0054 15.0 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DUF1456 PF07308.8 EWC46344.1 - 0.086 12.8 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1456) Ofd1_CTDD PF10637.4 EWC46345.1 - 8.4e-71 238.2 0.0 3.8e-64 216.3 0.1 3.0 2 1 0 2 2 2 2 Oxoglutarate and iron-dependent oxygenase degradation C-term 2OG-FeII_Oxy_3 PF13640.1 EWC46345.1 - 4.3e-16 59.2 0.0 8.8e-16 58.2 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.1 EWC46345.1 - 0.0089 15.6 0.0 0.02 14.5 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Daxx PF03344.10 EWC46345.1 - 4 5.8 15.2 7 5.0 10.5 1.3 1 0 0 1 1 1 0 Daxx Family DPPIV_N PF00930.16 EWC46347.1 - 2.2e-109 365.2 0.5 3.1e-109 364.7 0.3 1.2 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.16 EWC46347.1 - 9.5e-39 132.8 0.6 1.6e-38 132.0 0.4 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 EWC46347.1 - 8.3e-07 28.8 0.0 1.7e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S15 PF02129.13 EWC46347.1 - 0.00011 21.6 0.6 0.00076 18.9 0.1 2.3 1 1 1 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_6 PF12697.2 EWC46347.1 - 0.00011 22.1 0.0 0.00022 21.1 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.15 EWC46347.1 - 0.017 14.5 0.3 0.057 12.8 0.2 1.9 1 1 0 1 1 1 0 Putative esterase BAAT_C PF08840.6 EWC46347.1 - 0.11 12.2 0.0 4.6 6.8 0.0 2.3 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal PD40 PF07676.7 EWC46347.1 - 0.21 11.2 3.7 0.48 10.1 0.0 3.4 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat BRO1 PF03097.13 EWC46348.1 - 2.1e-09 36.6 0.1 3.7e-09 35.8 0.0 1.3 1 0 0 1 1 1 1 BRO1-like domain DD_K PF12121.3 EWC46348.1 - 3 7.8 6.2 17 5.4 0.1 2.7 2 0 0 2 2 2 0 Dermaseptin SNO PF01174.14 EWC46349.1 - 2.8e-53 180.3 0.0 4.9e-43 146.9 0.0 2.0 1 1 1 2 2 2 2 SNO glutamine amidotransferase family GATase_3 PF07685.9 EWC46349.1 - 2.2e-10 40.3 0.0 7.2e-09 35.4 0.0 2.1 2 0 0 2 2 2 1 CobB/CobQ-like glutamine amidotransferase domain DJ-1_PfpI PF01965.19 EWC46349.1 - 0.00011 21.6 0.0 0.00022 20.6 0.0 1.4 1 0 0 1 1 1 1 DJ-1/PfpI family GATase PF00117.23 EWC46349.1 - 0.00016 21.2 0.0 0.002 17.6 0.0 2.0 1 1 0 1 1 1 1 Glutamine amidotransferase class-I DUF4066 PF13278.1 EWC46349.1 - 0.00064 19.0 0.0 0.0012 18.1 0.0 1.4 1 0 0 1 1 1 1 Putative amidotransferase Peptidase_S51 PF03575.12 EWC46349.1 - 0.017 14.8 0.0 0.099 12.3 0.0 1.9 2 0 0 2 2 2 0 Peptidase family S51 Trypan_PARP PF05887.6 EWC46350.1 - 0.006 16.3 33.4 0.006 16.3 23.1 6.3 2 1 4 6 6 6 1 Procyclic acidic repetitive protein (PARP) Pex14_N PF04695.8 EWC46350.1 - 0.15 12.0 0.1 0.15 12.0 0.0 5.9 3 1 1 4 4 4 0 Peroxisomal membrane anchor protein (Pex14p) conserved region RINGv PF12906.2 EWC46351.1 - 3.5e-16 58.9 12.6 5.7e-16 58.2 8.8 1.3 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.1 EWC46351.1 - 0.015 15.1 10.6 0.026 14.3 7.4 1.4 1 0 0 1 1 1 0 Ring finger domain zf-Apc11 PF12861.2 EWC46351.1 - 0.22 11.3 4.9 0.44 10.4 3.4 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger FANCL_C PF11793.3 EWC46351.1 - 1.6 8.7 6.9 3.1 7.8 4.8 1.5 1 0 0 1 1 1 0 FANCL C-terminal domain Baculo_IE-1 PF05290.6 EWC46351.1 - 2.4 7.8 5.8 4.7 6.9 4.0 1.4 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) Velvet PF11754.3 EWC46352.1 - 0.0026 17.3 1.9 0.009 15.6 0.0 2.6 2 1 0 2 2 2 1 Velvet factor DUF2404 PF10296.4 EWC46353.1 - 3.5e-05 23.8 0.0 0.00056 19.9 0.0 2.2 2 0 0 2 2 2 1 Putative integral membrane protein conserved region (DUF2404) SGL PF08450.7 EWC46354.1 - 2.5e-26 92.5 0.1 8.6e-25 87.5 0.0 2.1 1 1 0 1 1 1 1 SMP-30/Gluconolaconase/LRE-like region Arylesterase PF01731.15 EWC46354.1 - 0.0058 16.5 0.1 0.021 14.8 0.0 2.0 1 1 1 2 2 2 1 Arylesterase NHL PF01436.16 EWC46354.1 - 0.1 12.6 0.0 33 4.6 0.0 3.0 2 0 0 2 2 2 0 NHL repeat Str_synth PF03088.11 EWC46354.1 - 0.16 12.0 0.0 0.61 10.1 0.0 2.0 2 0 0 2 2 2 0 Strictosidine synthase DUF4221 PF13970.1 EWC46354.1 - 0.16 11.2 0.0 0.29 10.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4221) p450 PF00067.17 EWC46355.1 - 6.1e-48 163.4 0.0 8.8e-48 162.9 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 An_peroxidase PF03098.10 EWC46356.1 - 1.5e-119 399.8 0.0 1.7e-119 399.6 0.0 1.0 1 0 0 1 1 1 1 Animal haem peroxidase AMP-binding PF00501.23 EWC46357.1 - 2.8e-150 500.3 0.0 4.4e-75 252.6 0.0 2.2 2 0 0 2 2 2 2 AMP-binding enzyme Condensation PF00668.15 EWC46357.1 - 1.4e-86 290.0 0.0 1.5e-38 132.3 0.0 4.3 3 1 1 4 4 4 4 Condensation domain PP-binding PF00550.20 EWC46357.1 - 2.6e-21 75.6 0.0 6.5e-12 45.5 0.0 2.6 2 0 0 2 2 2 2 Phosphopantetheine attachment site AMP-binding_C PF13193.1 EWC46357.1 - 1.9e-12 47.9 0.0 6.9e-05 23.7 0.0 3.1 3 0 0 3 3 3 2 AMP-binding enzyme C-terminal domain AMP-binding PF00501.23 EWC46359.1 - 4.4e-75 252.6 0.0 5.9e-75 252.2 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.20 EWC46359.1 - 5e-11 42.7 0.1 1.2e-10 41.5 0.1 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site Condensation PF00668.15 EWC46359.1 - 6.2e-06 25.2 0.0 0.00012 21.0 0.0 2.2 2 0 0 2 2 2 1 Condensation domain DIOX_N PF14226.1 EWC46360.1 - 2.4e-24 86.1 0.0 4.4e-24 85.2 0.0 1.5 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.15 EWC46360.1 - 2.1e-11 43.9 0.0 3.5e-11 43.2 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily GMC_oxred_N PF00732.14 EWC46362.1 - 3.9e-57 193.6 0.0 6.3e-57 192.9 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.8 EWC46362.1 - 3.3e-28 98.8 0.0 3.3e-28 98.8 0.0 1.7 2 0 0 2 2 2 1 GMC oxidoreductase CBM_1 PF00734.13 EWC46362.1 - 3.9e-13 48.8 9.1 8.8e-13 47.6 6.3 1.7 1 0 0 1 1 1 1 Fungal cellulose binding domain DAO PF01266.19 EWC46362.1 - 0.00023 20.2 0.0 0.08 11.8 0.0 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 EWC46362.1 - 0.00084 19.4 0.0 0.26 11.3 0.0 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 EWC46362.1 - 0.0019 18.2 0.2 0.012 15.6 0.1 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Mucin PF01456.12 EWC46362.1 - 0.0045 16.7 41.5 0.0045 16.7 28.7 2.1 2 0 0 2 2 2 1 Mucin-like glycoprotein NAD_binding_9 PF13454.1 EWC46362.1 - 0.026 14.3 0.2 0.21 11.3 0.0 2.4 2 0 0 2 2 2 0 FAD-NAD(P)-binding TrkA_N PF02254.13 EWC46362.1 - 0.087 12.8 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain Thi4 PF01946.12 EWC46362.1 - 0.18 10.8 1.3 0.33 10.0 0.0 1.9 2 0 0 2 2 2 0 Thi4 family OST3_OST6 PF04756.8 EWC46363.1 - 0.037 13.6 0.0 0.049 13.1 0.0 1.2 1 0 0 1 1 1 0 OST3 / OST6 family Abhydrolase_3 PF07859.8 EWC46364.1 - 3.5e-39 134.5 0.0 5.4e-39 133.9 0.0 1.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.23 EWC46364.1 - 1e-09 37.7 0.1 1.8e-09 36.8 0.1 1.3 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_5 PF12695.2 EWC46364.1 - 0.0011 18.7 0.0 0.0014 18.4 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.11 EWC46364.1 - 0.0046 16.4 0.0 0.014 14.8 0.0 1.7 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.16 EWC46364.1 - 0.028 13.6 0.0 1.6 7.9 0.0 2.3 2 0 0 2 2 2 0 Prolyl oligopeptidase family CFEM PF05730.6 EWC46365.1 - 7.8e-13 48.0 12.5 1.3e-12 47.3 8.6 1.3 1 0 0 1 1 1 1 CFEM domain Gamma-thionin PF00304.15 EWC46365.1 - 0.019 14.9 2.3 0.037 14.0 1.6 1.5 1 0 0 1 1 1 0 Gamma-thionin family PSII PF00421.14 EWC46367.1 - 0.16 10.4 1.7 0.21 10.1 1.1 1.1 1 0 0 1 1 1 0 Photosystem II protein Glyco_hydro_45 PF02015.11 EWC46368.1 - 1.3e-78 263.6 16.8 1.3e-78 263.6 11.7 1.7 2 0 0 2 2 2 1 Glycosyl hydrolase family 45 CBM_1 PF00734.13 EWC46368.1 - 7e-14 51.1 10.1 7e-14 51.1 7.0 3.0 2 0 0 2 2 2 1 Fungal cellulose binding domain Mucin PF01456.12 EWC46368.1 - 0.00011 21.9 45.4 0.00029 20.6 31.5 1.7 1 0 0 1 1 1 1 Mucin-like glycoprotein Ctf8 PF09696.5 EWC46369.1 - 0.024 14.4 0.0 0.034 13.9 0.0 1.2 1 0 0 1 1 1 0 Ctf8 Pyrid_oxidase_2 PF13883.1 EWC46370.1 - 7.2e-45 152.8 0.0 8.4e-45 152.5 0.0 1.0 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase SH3_2 PF07653.12 EWC46372.1 - 0.00085 18.7 0.1 0.0019 17.6 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.1 EWC46372.1 - 0.0048 16.4 0.3 0.01 15.4 0.2 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 EWC46372.1 - 0.036 13.4 0.6 0.09 12.1 0.4 1.8 1 0 0 1 1 1 0 SH3 domain HisKA PF00512.20 EWC46372.1 - 0.08 12.9 0.0 0.34 10.9 0.0 2.0 2 0 0 2 2 2 0 His Kinase A (phospho-acceptor) domain UvrD-helicase PF00580.16 EWC46373.1 - 3.7e-14 52.7 0.0 3.8e-11 42.8 0.0 2.3 2 0 0 2 2 2 2 UvrD/REP helicase N-terminal domain Viral_helicase1 PF01443.13 EWC46373.1 - 1.5e-11 44.2 0.0 0.0014 18.2 0.0 4.1 4 0 0 4 4 4 2 Viral (Superfamily 1) RNA helicase UvrD_C PF13361.1 EWC46373.1 - 1.8e-09 37.5 0.0 5.1e-09 36.0 0.0 1.5 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain UvrD_C_2 PF13538.1 EWC46373.1 - 9e-09 35.4 0.0 2.1e-08 34.2 0.0 1.7 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_19 PF13245.1 EWC46373.1 - 6.3e-05 22.6 0.0 0.002 17.8 0.0 2.8 3 0 0 3 3 3 1 Part of AAA domain AAA_30 PF13604.1 EWC46373.1 - 0.0043 16.6 0.0 0.17 11.4 0.0 2.3 2 0 0 2 2 2 1 AAA domain PhoH PF02562.11 EWC46373.1 - 0.0086 15.3 0.0 0.78 8.9 0.0 2.2 2 0 0 2 2 2 1 PhoH-like protein AAA_11 PF13086.1 EWC46373.1 - 0.07 12.6 0.0 0.55 9.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain Tyrosinase PF00264.15 EWC46374.1 - 1.3e-43 149.6 2.4 3.1e-43 148.4 1.7 1.7 1 0 0 1 1 1 1 Common central domain of tyrosinase Abhydrolase_3 PF07859.8 EWC46376.1 - 1.1e-12 47.9 0.1 7.2e-09 35.5 0.0 3.2 2 1 1 3 3 3 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 EWC46376.1 - 0.044 13.6 9.0 0.014 15.2 2.9 2.3 2 1 0 2 2 2 0 Alpha/beta hydrolase family DUF3592 PF12158.3 EWC46376.1 - 0.11 12.3 0.0 0.18 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3592) MFS_1 PF07690.11 EWC46378.1 - 2.2e-39 135.1 31.1 2.3e-39 135.1 19.5 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.8 EWC46378.1 - 3.3e-11 42.1 1.9 6.4e-11 41.1 1.3 1.4 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.19 EWC46378.1 - 2.6e-10 39.4 24.6 9.4e-10 37.6 17.0 1.7 1 1 0 1 1 1 1 Sugar (and other) transporter Flavokinase PF01687.12 EWC46379.1 - 5.8e-39 132.8 0.0 6.7e-39 132.6 0.0 1.0 1 0 0 1 1 1 1 Riboflavin kinase DUF1365 PF07103.6 EWC46380.1 - 3.2e-28 98.4 0.1 5.5e-28 97.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1365) Dus PF01207.12 EWC46380.1 - 0.016 14.0 0.0 1.1 8.0 0.0 2.1 2 0 0 2 2 2 0 Dihydrouridine synthase (Dus) p450 PF00067.17 EWC46381.1 - 9.1e-27 93.6 0.0 2e-25 89.2 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 CorA PF01544.13 EWC46382.1 - 1.3e-14 53.9 2.4 1.3e-13 50.7 0.1 2.1 2 0 0 2 2 2 2 CorA-like Mg2+ transporter protein HECT PF00632.20 EWC46383.1 - 8.8e-73 245.2 0.0 4.6e-72 242.8 0.0 2.0 1 1 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Pkinase PF00069.20 EWC46384.1 - 2.4e-69 233.4 0.0 3.2e-69 232.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC46384.1 - 9e-31 106.8 0.0 1.3e-30 106.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 EWC46384.1 - 0.027 14.2 0.1 0.069 12.8 0.0 1.6 1 1 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.1 EWC46384.1 - 0.077 11.9 0.0 0.17 10.7 0.0 1.5 1 1 0 1 1 1 0 Kinase-like 2OG-FeII_Oxy_2 PF13532.1 EWC46385.1 - 1.4e-27 96.7 0.0 2.4e-27 96.0 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily His_Phos_1 PF00300.17 EWC46386.1 - 6.5e-15 55.5 0.0 1.5e-14 54.3 0.0 1.6 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Transket_pyr PF02779.19 EWC46389.1 - 1.6e-40 138.4 0.0 3.3e-40 137.4 0.0 1.5 2 0 0 2 2 2 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.15 EWC46389.1 - 6.8e-32 110.0 0.1 1.6e-31 108.8 0.0 1.6 1 0 0 1 1 1 1 Transketolase, C-terminal domain Dak2 PF02734.12 EWC46390.1 - 0.013 15.1 3.5 0.013 15.1 2.4 2.0 2 0 0 2 2 2 0 DAK2 domain TraQ PF09679.5 EWC46390.1 - 0.33 10.8 0.1 0.33 10.8 0.0 2.6 2 0 0 2 2 2 0 Type-F conjugative transfer system pilin chaperone (TraQ) Big_5 PF13205.1 EWC46392.1 - 0.0022 18.5 0.1 0.0068 16.9 0.0 1.8 2 0 0 2 2 2 1 Bacterial Ig-like domain SKG6 PF08693.5 EWC46393.1 - 0.0016 17.7 0.1 0.0016 17.7 0.1 2.5 3 0 0 3 3 3 1 Transmembrane alpha-helix domain Corona_NS4 PF03905.8 EWC46393.1 - 0.0077 16.0 0.0 0.0077 16.0 0.0 3.4 2 1 1 3 3 3 1 Coronavirus non-structural protein NS4 CAF-1_p150 PF11600.3 EWC46394.1 - 0.00021 20.7 11.5 0.00021 20.7 8.0 1.5 2 0 0 2 2 2 1 Chromatin assembly factor 1 complex p150 subunit, N-terminal LUC7 PF03194.10 EWC46395.1 - 3.3e-73 246.3 0.3 4.2e-73 246.0 0.2 1.0 1 0 0 1 1 1 1 LUC7 N_terminus Sec66 PF09802.4 EWC46395.1 - 0.021 14.2 0.4 0.031 13.6 0.3 1.2 1 0 0 1 1 1 0 Preprotein translocase subunit Sec66 DUF2225 PF09986.4 EWC46395.1 - 0.092 12.1 0.3 0.61 9.5 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) Dynamin_M PF01031.15 EWC46396.1 - 1.1e-26 93.3 0.1 1.1e-16 60.4 0.0 2.2 2 0 0 2 2 2 2 Dynamin central region Dynamin_N PF00350.18 EWC46396.1 - 6.6e-25 87.8 0.0 2.4e-24 86.0 0.0 2.0 1 1 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.18 EWC46396.1 - 5.7e-07 29.5 0.1 1.1e-05 25.3 0.1 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase GED PF02212.13 EWC46396.1 - 0.00068 19.4 3.3 0.0011 18.8 0.1 3.0 3 0 0 3 3 3 1 Dynamin GTPase effector domain FeoB_N PF02421.13 EWC46396.1 - 0.0049 16.1 0.0 0.3 10.3 0.0 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B Miro PF08477.8 EWC46396.1 - 0.0052 17.2 0.0 0.015 15.8 0.0 1.8 1 0 0 1 1 1 1 Miro-like protein DUF726 PF05277.7 EWC46396.1 - 0.022 13.6 1.0 0.037 12.9 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF726) AAA_29 PF13555.1 EWC46396.1 - 0.039 13.4 0.0 0.19 11.3 0.0 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain ABC_tran PF00005.22 EWC46396.1 - 0.058 13.6 0.0 0.22 11.8 0.0 2.0 2 0 0 2 2 2 0 ABC transporter AAA_21 PF13304.1 EWC46396.1 - 0.2 11.5 0.0 0.42 10.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain Fe-ADH PF00465.14 EWC46397.1 - 2.5e-101 338.9 0.0 3.1e-101 338.6 0.0 1.1 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.1 EWC46397.1 - 7.7e-15 54.8 0.0 3.6e-11 42.8 0.0 2.2 2 0 0 2 2 2 2 Iron-containing alcohol dehydrogenase VHS PF00790.14 EWC46398.1 - 5.4e-22 77.9 0.0 1.4e-21 76.6 0.0 1.6 2 0 0 2 2 2 1 VHS domain GAT PF03127.9 EWC46398.1 - 6e-07 29.3 0.1 1.2e-06 28.4 0.0 1.4 1 0 0 1 1 1 1 GAT domain Fes1 PF08609.5 EWC46398.1 - 0.11 13.0 0.3 0.27 11.7 0.2 1.6 1 0 0 1 1 1 0 Nucleotide exchange factor Fes1 HSP70 PF00012.15 EWC46399.1 - 4.5e-263 873.6 13.2 5.2e-263 873.4 9.2 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 EWC46399.1 - 2.9e-18 65.5 1.5 7.4e-17 60.9 0.3 2.1 2 0 0 2 2 2 2 MreB/Mbl protein Hydantoinase_A PF01968.13 EWC46399.1 - 0.0032 16.6 6.0 0.035 13.1 0.2 3.4 3 0 0 3 3 3 1 Hydantoinase/oxoprolinase FtsA PF14450.1 EWC46399.1 - 0.86 9.4 6.5 3.4 7.5 0.4 3.3 1 1 1 2 2 2 0 Cell division protein FtsA Pantoate_ligase PF02569.10 EWC46400.1 - 3.4e-86 288.4 0.0 4.3e-86 288.1 0.0 1.1 1 0 0 1 1 1 1 Pantoate-beta-alanine ligase Glyco_hydro_100 PF12899.2 EWC46400.1 - 0.13 10.5 0.0 0.18 10.1 0.0 1.1 1 0 0 1 1 1 0 Alkaline and neutral invertase Rtf2 PF04641.7 EWC46401.1 - 2.3e-59 200.7 1.5 3.1e-59 200.3 1.1 1.2 1 0 0 1 1 1 1 Rtf2 RING-finger zf-Nse PF11789.3 EWC46401.1 - 3.5e-05 23.2 0.0 0.02 14.3 0.0 2.4 2 0 0 2 2 2 2 Zinc-finger of the MIZ type in Nse subunit zf-RING_2 PF13639.1 EWC46401.1 - 0.0012 18.6 0.1 0.14 11.9 0.0 2.4 2 0 0 2 2 2 1 Ring finger domain zf-RING_UBOX PF13445.1 EWC46401.1 - 0.007 16.0 2.9 0.015 15.0 0.1 2.9 3 0 0 3 3 3 1 RING-type zinc-finger zf-RING_5 PF14634.1 EWC46401.1 - 0.028 14.1 0.1 0.052 13.2 0.1 1.5 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_3 PF13920.1 EWC46401.1 - 0.059 13.0 0.1 0.12 12.1 0.1 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Baculo_RING PF05883.6 EWC46401.1 - 0.084 12.7 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 Baculovirus U-box/Ring-like domain Tmemb_cc2 PF10267.4 EWC46401.1 - 0.69 8.4 6.6 1.1 7.7 4.6 1.2 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein POX PF07526.6 EWC46401.1 - 2.3 8.4 7.0 5.3 7.2 4.8 1.7 1 0 0 1 1 1 0 Associated with HOX Tim17 PF02466.14 EWC46402.1 - 2.8e-32 111.4 6.5 3.5e-32 111.1 4.5 1.0 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family tRNA-synt_2 PF00152.15 EWC46403.1 - 2.4e-89 299.4 1.8 3.5e-89 298.8 1.3 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 EWC46403.1 - 2.3e-09 36.9 0.0 5.6e-09 35.7 0.0 1.7 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.15 EWC46403.1 - 1.6e-06 27.5 0.1 0.0024 17.1 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) tRNA-synt_2b PF00587.20 EWC46403.1 - 0.02 14.4 0.1 0.89 9.1 0.0 2.4 2 0 0 2 2 2 0 tRNA synthetase class II core domain (G, H, P, S and T) UCH PF00443.24 EWC46404.1 - 4.6e-66 222.6 0.0 8.2e-66 221.8 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 EWC46404.1 - 1.6e-26 93.4 0.0 3.9e-26 92.1 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Rhodanese PF00581.15 EWC46404.1 - 0.00098 19.4 0.0 0.0026 18.1 0.0 1.7 1 0 0 1 1 1 1 Rhodanese-like domain zf-MIZ PF02891.15 EWC46404.1 - 0.047 13.2 0.2 0.098 12.1 0.1 1.5 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger VHS PF00790.14 EWC46405.1 - 6.3e-41 139.3 0.1 6.3e-41 139.3 0.0 2.0 2 0 0 2 2 2 1 VHS domain FYVE PF01363.16 EWC46405.1 - 4.6e-18 64.8 6.1 9.7e-18 63.8 4.2 1.5 1 0 0 1 1 1 1 FYVE zinc finger FYVE_2 PF02318.11 EWC46405.1 - 0.009 15.9 5.0 0.02 14.8 3.5 1.5 1 0 0 1 1 1 1 FYVE-type zinc finger IBR PF01485.16 EWC46405.1 - 0.032 14.1 2.3 0.079 12.8 1.6 1.6 1 0 0 1 1 1 0 IBR domain UIM PF02809.15 EWC46405.1 - 0.16 11.6 12.4 0.53 10.0 2.4 2.7 2 0 0 2 2 2 0 Ubiquitin interaction motif C1_4 PF07975.7 EWC46405.1 - 6.1 6.9 8.8 8.5 6.4 4.3 2.3 2 0 0 2 2 2 0 TFIIH C1-like domain APG12 PF04110.8 EWC46406.1 - 3.3e-25 88.0 0.3 1.2e-15 57.4 0.0 2.2 2 0 0 2 2 2 2 Ubiquitin-like autophagy protein Apg12 Asparaginase_2 PF01112.13 EWC46407.1 - 1.6e-56 191.3 0.1 4.4e-47 160.3 0.0 2.1 2 0 0 2 2 2 2 Asparaginase UAA PF08449.6 EWC46408.1 - 0.00095 18.1 3.6 0.00095 18.1 2.5 2.5 3 0 0 3 3 3 2 UAA transporter family CYTH PF01928.16 EWC46409.1 - 8.5e-15 54.8 0.0 1.3e-14 54.3 0.0 1.2 1 0 0 1 1 1 1 CYTH domain DUF4285 PF14113.1 EWC46409.1 - 0.092 12.7 0.4 0.61 10.0 0.3 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4285) Radical_SAM PF04055.16 EWC46410.1 - 2e-14 54.1 0.1 4.7e-14 52.8 0.0 1.6 2 0 0 2 2 2 1 Radical SAM superfamily Fer4_14 PF13394.1 EWC46410.1 - 7.5e-09 35.6 0.1 2.2e-08 34.1 0.0 1.7 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_12 PF13353.1 EWC46410.1 - 4e-08 33.4 0.1 9.8e-08 32.2 0.1 1.6 1 0 0 1 1 1 1 4Fe-4S single cluster domain zf-C2H2_7 PF15269.1 EWC46410.1 - 0.098 12.5 3.1 0.5 10.2 0.2 2.6 2 0 0 2 2 2 0 Zinc-finger CHD5 PF04420.9 EWC46411.1 - 0.0033 17.0 0.4 0.0068 16.0 0.3 1.5 1 0 0 1 1 1 1 CHD5-like protein COX15-CtaA PF02628.10 EWC46412.1 - 4.3e-89 298.3 1.4 5.6e-89 297.9 1.0 1.1 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein p450 PF00067.17 EWC46413.1 - 1.5e-77 261.0 0.0 1.9e-77 260.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 HypD PF01924.11 EWC46413.1 - 0.025 13.3 0.0 0.039 12.7 0.0 1.2 1 0 0 1 1 1 0 Hydrogenase formation hypA family DUF1196 PF06709.6 EWC46413.1 - 0.1 12.5 0.2 0.27 11.2 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1196) NA37 PF04245.8 EWC46413.1 - 0.12 11.6 0.0 0.21 10.8 0.0 1.3 1 0 0 1 1 1 0 37-kD nucleoid-associated bacterial protein DUF2828 PF11443.3 EWC46414.1 - 1.1e-141 472.7 0.0 1.3e-141 472.4 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF2828) Asp PF00026.18 EWC46415.1 - 3.2e-18 66.0 0.0 5.4e-18 65.2 0.0 1.3 1 1 0 1 1 1 1 Eukaryotic aspartyl protease DUF4366 PF14283.1 EWC46415.1 - 0.014 14.8 0.0 0.022 14.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) SKG6 PF08693.5 EWC46415.1 - 0.028 13.7 0.1 0.066 12.5 0.1 1.7 1 0 0 1 1 1 0 Transmembrane alpha-helix domain CD99L2 PF12301.3 EWC46415.1 - 0.053 13.2 0.1 0.099 12.3 0.1 1.4 1 0 0 1 1 1 0 CD99 antigen like protein 2 MARVEL PF01284.18 EWC46416.1 - 0.0015 18.3 17.1 0.0025 17.6 11.8 1.3 1 0 0 1 1 1 1 Membrane-associating domain zf-C2H2_2 PF12756.2 EWC46417.1 - 3.3e-33 113.8 16.4 1.6e-30 105.1 0.0 3.6 4 0 0 4 4 4 3 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.3 EWC46417.1 - 2.2e-07 30.7 14.3 0.00041 20.3 0.4 3.9 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 EWC46417.1 - 0.0022 18.1 0.8 0.0022 18.1 0.6 3.5 4 0 0 4 4 4 2 Zinc-finger of C2H2 type zf-C2H2 PF00096.21 EWC46417.1 - 2.9 8.4 17.4 0.73 10.3 0.8 4.3 4 0 0 4 4 4 0 Zinc finger, C2H2 type GCC2_GCC3 PF07699.8 EWC46417.1 - 7.2 6.2 8.5 2 8.0 0.2 3.4 4 0 0 4 4 4 0 GCC2 and GCC3 Peptidase_M20 PF01546.23 EWC46418.1 - 3.8e-24 85.2 0.0 7.6e-24 84.2 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 WD40 PF00400.27 EWC46418.1 - 3e-12 45.8 13.4 0.00081 19.1 0.0 5.9 5 0 0 5 5 5 4 WD domain, G-beta repeat M20_dimer PF07687.9 EWC46418.1 - 1.2e-08 34.7 0.0 2.6e-08 33.5 0.0 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain PQQ_3 PF13570.1 EWC46418.1 - 0.019 15.2 0.1 1.1 9.5 0.0 3.7 3 1 0 3 3 3 0 PQQ-like domain Na_Ca_ex PF01699.19 EWC46419.1 - 5e-39 133.0 34.8 3.5e-23 81.7 10.3 2.4 2 0 0 2 2 2 2 Sodium/calcium exchanger protein F-box-like PF12937.2 EWC46421.1 - 0.14 11.8 0.1 0.14 11.8 0.0 2.0 2 0 0 2 2 2 0 F-box-like Cu_bind_like PF02298.12 EWC46422.1 - 0.002 17.8 0.2 0.0055 16.4 0.2 1.7 1 1 0 1 1 1 1 Plastocyanin-like domain SbmA_BacA PF05992.7 EWC46423.1 - 0.041 13.0 1.0 0.06 12.5 0.7 1.2 1 0 0 1 1 1 0 SbmA/BacA-like family Atx10homo_assoc PF09759.4 EWC46424.1 - 1.5e-30 104.9 0.2 2.8e-30 104.0 0.1 1.5 1 0 0 1 1 1 1 Spinocerebellar ataxia type 10 protein domain DUF4290 PF14123.1 EWC46424.1 - 0.015 14.4 0.0 1.1 8.4 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4290) DUF21 PF01595.15 EWC46425.1 - 6.6e-35 120.0 0.1 1.1e-34 119.3 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function DUF21 CBS PF00571.23 EWC46425.1 - 8.2e-07 28.7 0.1 0.063 13.0 0.0 2.8 1 1 1 2 2 2 2 CBS domain Transp_cyt_pur PF02133.10 EWC46426.1 - 9.4e-84 281.4 28.9 1.2e-83 281.1 20.0 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin CVNH PF08881.5 EWC46428.1 - 3.8e-12 46.3 0.0 1.8e-08 34.5 0.0 2.4 1 1 1 2 2 2 2 CVNH domain DUF4630 PF15443.1 EWC46428.1 - 0.57 9.9 4.9 0.12 12.2 0.8 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4630) F-box PF00646.28 EWC46430.1 - 0.021 14.4 0.4 0.12 12.0 0.0 2.5 2 0 0 2 2 2 0 F-box domain zf-RING_2 PF13639.1 EWC46431.1 - 1.4e-08 34.4 3.3 2.2e-08 33.7 2.3 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 EWC46431.1 - 1.2e-07 31.6 1.7 2.8e-07 30.5 1.1 1.6 1 1 0 1 1 1 1 RING-H2 zinc finger zf-Apc11 PF12861.2 EWC46431.1 - 0.00089 19.0 0.7 0.0014 18.4 0.5 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.1 EWC46431.1 - 0.072 13.1 3.0 0.14 12.1 2.1 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EWC46431.1 - 0.14 11.8 1.1 0.33 10.6 0.8 1.6 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF747 PF05346.6 EWC46432.1 - 9.6e-126 419.3 0.2 1.2e-125 418.9 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic membrane protein family Pyridox_oxidase PF01243.15 EWC46433.1 - 6.6e-08 32.4 0.0 0.0011 18.9 0.0 2.5 2 0 0 2 2 2 2 Pyridoxamine 5'-phosphate oxidase FAD_binding_6 PF00970.19 EWC46433.1 - 4e-07 30.0 0.0 0.014 15.4 0.0 2.4 1 1 1 2 2 2 2 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.16 EWC46433.1 - 0.00073 20.0 0.1 0.0022 18.5 0.0 1.8 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.7 EWC46433.1 - 0.077 12.9 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 Ferric reductase NAD binding domain Rap1_C PF11626.3 EWC46434.1 - 1.7e-10 40.6 0.1 4.1e-10 39.4 0.1 1.7 1 0 0 1 1 1 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain Myb_DNA-bind_2 PF08914.6 EWC46434.1 - 3.7e-08 33.0 1.9 3.7e-08 33.0 1.3 2.2 2 0 0 2 2 2 1 Rap1 Myb domain PBP1_TM PF14812.1 EWC46434.1 - 0.54 10.6 4.7 17 5.7 0.4 2.9 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal zf-DHHC PF01529.15 EWC46435.1 - 4.1e-34 117.4 13.9 7.6e-34 116.6 9.6 1.5 1 0 0 1 1 1 1 DHHC palmitoyltransferase PSI PF01437.20 EWC46435.1 - 0.022 14.8 3.5 0.048 13.8 2.4 1.5 1 0 0 1 1 1 0 Plexin repeat RolB_RolC PF02027.12 EWC46435.1 - 0.081 12.0 0.1 0.13 11.4 0.0 1.2 1 0 0 1 1 1 0 RolB/RolC glucosidase family F-box-like PF12937.2 EWC46436.1 - 0.021 14.5 0.1 0.046 13.4 0.1 1.6 1 0 0 1 1 1 0 F-box-like F-box PF00646.28 EWC46436.1 - 0.046 13.3 0.0 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 F-box domain BTK PF00779.14 EWC46436.1 - 0.14 11.7 1.2 0.27 10.8 0.9 1.4 1 0 0 1 1 1 0 BTK motif SelR PF01641.13 EWC46437.1 - 1.9e-52 176.1 0.1 2.2e-52 175.9 0.1 1.0 1 0 0 1 1 1 1 SelR domain DUF2296 PF10058.4 EWC46437.1 - 0.019 14.7 0.5 2.5 7.9 0.0 2.3 2 0 0 2 2 2 0 Predicted integral membrane metal-binding protein (DUF2296) TF_Zn_Ribbon PF08271.7 EWC46437.1 - 0.14 11.4 0.2 0.14 11.4 0.2 2.6 3 0 0 3 3 3 0 TFIIB zinc-binding DZR PF12773.2 EWC46437.1 - 0.58 10.0 3.4 18 5.2 0.3 2.4 1 1 1 2 2 2 0 Double zinc ribbon Carb_anhydrase PF00194.16 EWC46438.1 - 1.7e-18 66.5 0.1 4.9e-18 65.0 0.0 1.6 1 1 0 1 1 1 1 Eukaryotic-type carbonic anhydrase MFS_1 PF07690.11 EWC46439.1 - 1.8e-40 138.7 48.8 1.8e-40 138.7 33.8 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EWC46439.1 - 5.2e-13 48.3 13.4 5.2e-13 48.3 9.3 3.1 3 0 0 3 3 3 1 Sugar (and other) transporter NTP_transferase PF00483.18 EWC46440.1 - 2e-30 105.9 0.0 3.6e-30 105.0 0.0 1.4 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.19 EWC46440.1 - 1.8e-08 33.5 4.5 1.1e-05 24.7 0.0 3.8 2 1 1 3 3 3 2 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.2 EWC46440.1 - 1.4e-06 28.5 0.0 2.6e-06 27.5 0.0 1.5 1 0 0 1 1 1 1 MobA-like NTP transferase domain Peptidase_S28 PF05577.7 EWC46442.1 - 4.5e-50 170.5 0.4 8.1e-50 169.6 0.3 1.3 1 1 0 1 1 1 1 Serine carboxypeptidase S28 APH PF01636.18 EWC46443.1 - 8.7e-08 32.1 0.0 1.7e-07 31.2 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Ran-binding PF05508.6 EWC46444.1 - 6.9e-99 330.5 0.0 9.4e-99 330.1 0.0 1.2 1 0 0 1 1 1 1 RanGTP-binding protein SDA1 PF05285.7 EWC46444.1 - 0.0089 15.3 1.9 0.0089 15.3 1.3 2.1 3 0 0 3 3 3 1 SDA1 Nucleoplasmin PF03066.10 EWC46444.1 - 3.3 7.2 16.0 12 5.3 9.8 2.4 2 0 0 2 2 2 0 Nucleoplasmin Copper-fist PF00649.13 EWC46445.1 - 6.5e-20 70.0 1.2 6.5e-20 70.0 0.8 3.4 2 1 1 3 3 3 1 Copper fist DNA binding domain Metallothio_Pro PF02069.11 EWC46445.1 - 1.2 8.9 15.1 0.085 12.6 0.6 3.4 3 0 0 3 3 3 0 Prokaryotic metallothionein Fungal_trans PF04082.13 EWC46446.1 - 6.8e-08 31.6 0.0 1.3e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zds_C PF08632.5 EWC46447.1 - 1.9e-28 97.5 1.2 3.3e-28 96.8 0.8 1.4 1 0 0 1 1 1 1 Activator of mitotic machinery Cdc14 phosphatase activation C-term Kei1 PF08552.6 EWC46447.1 - 4.7 6.8 5.8 12 5.4 4.0 1.6 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 KH_1 PF00013.24 EWC46448.1 - 4.5e-113 368.9 43.3 2e-14 52.9 0.2 14.4 13 1 0 13 13 13 13 KH domain KH_3 PF13014.1 EWC46448.1 - 4.1e-75 246.4 32.9 1.1e-09 37.7 0.3 14.7 13 1 1 14 14 14 13 KH domain KH_2 PF07650.12 EWC46448.1 - 7.4e-09 35.0 33.6 0.017 14.6 1.0 9.5 7 2 1 9 9 9 4 KH domain SLS PF14611.1 EWC46448.1 - 7e-05 22.3 18.0 8.4 5.7 0.0 8.3 6 3 3 9 9 9 5 Mitochondrial inner-membrane-bound regulator KH_4 PF13083.1 EWC46448.1 - 1.5 8.5 21.2 0.19 11.3 0.5 6.6 8 0 0 8 8 8 0 KH domain GTP_EFTU PF00009.22 EWC46449.1 - 4.8e-44 150.0 0.0 8.2e-44 149.2 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 EWC46449.1 - 2.9e-20 72.2 0.0 7.2e-20 71.0 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 EWC46449.1 - 3.1e-07 30.4 0.1 8.3e-07 29.0 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 EWC46449.1 - 9.9e-05 22.2 0.0 0.00023 21.0 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase GRP PF07172.6 EWC46449.1 - 0.41 11.1 23.2 1.6 9.2 16.1 2.1 1 0 0 1 1 1 0 Glycine rich protein family G-alpha PF00503.15 EWC46449.1 - 6.9 5.2 6.7 85 1.6 4.7 2.2 1 1 0 1 1 1 0 G-protein alpha subunit EF_assoc_2 PF08356.7 EWC46450.1 - 5.8e-35 118.9 0.0 1.2e-34 117.9 0.0 1.5 1 0 0 1 1 1 1 EF hand associated EF_assoc_1 PF08355.7 EWC46450.1 - 5.3e-28 96.1 0.3 9.1e-28 95.3 0.2 1.4 1 0 0 1 1 1 1 EF hand associated Miro PF08477.8 EWC46450.1 - 1.9e-25 89.6 0.0 6e-12 46.1 0.0 2.4 2 0 0 2 2 2 2 Miro-like protein Ras PF00071.17 EWC46450.1 - 3e-16 59.2 0.0 8.1e-09 35.0 0.0 2.2 2 0 0 2 2 2 2 Ras family MMR_HSR1 PF01926.18 EWC46450.1 - 1.4e-07 31.4 0.0 0.0079 16.1 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase EF-hand_1 PF00036.27 EWC46450.1 - 2.1e-07 29.7 1.2 0.0077 15.4 0.0 2.7 2 0 0 2 2 2 2 EF hand Dynamin_N PF00350.18 EWC46450.1 - 2.6e-07 30.6 0.0 0.003 17.3 0.0 2.6 2 1 0 2 2 2 2 Dynamin family EF-hand_7 PF13499.1 EWC46450.1 - 2.9e-07 30.5 0.1 0.025 14.7 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 EWC46450.1 - 1.2e-06 27.9 1.5 0.0081 15.9 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain AAA_16 PF13191.1 EWC46450.1 - 0.00035 20.6 0.0 0.11 12.5 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain EF-hand_5 PF13202.1 EWC46450.1 - 0.00043 19.4 4.0 0.018 14.3 0.2 2.7 2 0 0 2 2 2 1 EF hand GTP_EFTU PF00009.22 EWC46450.1 - 0.00079 18.8 0.0 0.89 8.9 0.0 3.1 3 0 0 3 3 3 1 Elongation factor Tu GTP binding domain AAA_29 PF13555.1 EWC46450.1 - 0.00098 18.6 0.0 0.033 13.7 0.0 2.3 2 0 0 2 2 2 1 P-loop containing region of AAA domain EF-hand_8 PF13833.1 EWC46450.1 - 0.0023 17.5 0.7 0.49 10.0 0.0 2.6 2 0 0 2 2 2 1 EF-hand domain pair AAA_28 PF13521.1 EWC46450.1 - 0.0023 17.9 0.0 0.15 12.0 0.0 2.8 3 0 0 3 3 2 1 AAA domain EF-hand_10 PF14788.1 EWC46450.1 - 0.013 15.0 1.6 0.02 14.5 0.2 2.0 2 0 0 2 2 2 0 EF hand MobB PF03205.9 EWC46450.1 - 0.03 14.0 0.0 9.1 5.9 0.0 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_33 PF13671.1 EWC46450.1 - 0.047 13.5 0.0 2.8 7.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_21 PF13304.1 EWC46450.1 - 0.085 12.7 0.0 0.68 9.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain SRPRB PF09439.5 EWC46450.1 - 0.088 12.0 0.0 7 5.8 0.0 2.6 2 1 0 2 2 2 0 Signal recognition particle receptor beta subunit AAA_22 PF13401.1 EWC46450.1 - 0.096 12.8 0.0 5.5 7.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.1 EWC46450.1 - 0.19 12.0 0.0 52 4.1 0.0 3.1 3 1 0 3 3 2 0 AAA domain GST_N_2 PF13409.1 EWC46451.1 - 4.7e-22 77.7 0.0 9.3e-22 76.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 EWC46451.1 - 6.7e-15 54.7 0.0 1.4e-14 53.6 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 EWC46451.1 - 4.4e-06 27.0 0.0 9e-06 26.0 0.0 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 EWC46451.1 - 7.7e-06 25.8 0.1 1.8e-05 24.6 0.1 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.1 EWC46451.1 - 0.00014 22.0 0.0 0.0016 18.6 0.0 2.2 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain RLI PF04068.10 EWC46451.1 - 0.16 11.5 0.0 0.3 10.6 0.0 1.3 1 0 0 1 1 1 0 Possible Fer4-like domain in RNase L inhibitor, RLI GTP_EFTU PF00009.22 EWC46452.1 - 4.2e-50 169.7 0.0 6.8e-50 169.1 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain HBS1_N PF08938.5 EWC46452.1 - 3.2e-18 65.6 0.2 6.2e-18 64.7 0.1 1.4 1 0 0 1 1 1 1 HBS1 N-terminus GTP_EFTU_D2 PF03144.20 EWC46452.1 - 5.5e-08 32.8 1.2 1.6e-07 31.3 0.8 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 EWC46452.1 - 1.5e-07 31.3 0.0 2.4e-06 27.4 0.0 2.7 2 1 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU_D3 PF03143.12 EWC46452.1 - 0.00011 22.2 0.0 0.00039 20.5 0.0 2.1 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain Miro PF08477.8 EWC46452.1 - 0.00021 21.7 0.0 0.0079 16.6 0.0 2.5 1 1 0 1 1 1 1 Miro-like protein Ras PF00071.17 EWC46452.1 - 0.00097 18.5 0.0 0.029 13.7 0.0 2.3 1 1 1 2 2 2 1 Ras family GTP_EFTU_D4 PF14578.1 EWC46452.1 - 0.0025 17.3 1.1 0.007 15.9 0.8 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 4 G-alpha PF00503.15 EWC46452.1 - 0.0044 15.7 1.1 0.0069 15.1 0.8 1.3 1 0 0 1 1 1 1 G-protein alpha subunit SRPRB PF09439.5 EWC46452.1 - 0.0068 15.6 0.0 0.76 8.9 0.0 2.6 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Septin PF00735.13 EWC46452.1 - 0.043 12.8 0.0 0.13 11.2 0.0 1.8 2 1 0 2 2 2 0 Septin Peptidase_M14 PF00246.19 EWC46453.1 - 5.8e-68 229.5 0.0 7.1e-68 229.2 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase Aft1_HRA PF11786.3 EWC46453.1 - 0.014 15.6 0.2 0.057 13.6 0.0 2.3 3 0 0 3 3 3 0 Aft1 HRA domain ANP PF00212.13 EWC46453.1 - 0.15 12.1 0.5 0.29 11.2 0.3 1.5 1 0 0 1 1 1 0 Atrial natriuretic peptide Podoplanin PF05808.6 EWC46454.1 - 0.014 14.9 1.0 0.019 14.4 0.7 1.1 1 0 0 1 1 1 0 Podoplanin CFEM PF05730.6 EWC46454.1 - 0.018 14.8 0.7 0.018 14.8 0.5 1.7 2 0 0 2 2 2 0 CFEM domain SKG6 PF08693.5 EWC46454.1 - 0.057 12.7 2.1 0.15 11.4 1.4 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Rax2 PF12768.2 EWC46454.1 - 0.16 11.1 0.0 0.25 10.5 0.0 1.3 1 0 0 1 1 1 0 Cortical protein marker for cell polarity Tannase PF07519.6 EWC46455.1 - 2.5e-93 313.3 0.0 8.4e-93 311.6 0.0 1.7 1 1 0 1 1 1 1 Tannase and feruloyl esterase Abhydrolase_6 PF12697.2 EWC46455.1 - 0.00048 20.0 0.0 0.00079 19.3 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EWC46455.1 - 0.0033 17.0 0.0 0.0045 16.5 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EWC46455.1 - 0.0096 15.6 0.0 0.084 12.6 0.0 2.1 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 EWC46457.1 - 2.2e-20 73.5 1.2 3.6e-20 72.8 0.8 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EWC46457.1 - 7.9e-09 35.4 0.0 1.2e-08 34.8 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EWC46457.1 - 3.3e-06 26.8 0.0 4.1e-05 23.2 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Glyco_hydro_62 PF03664.8 EWC46459.1 - 5.3e-140 465.1 12.4 6.6e-140 464.8 8.6 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 62 CBM_1 PF00734.13 EWC46459.1 - 6.8e-10 38.4 11.3 1.8e-09 37.0 7.9 1.8 1 0 0 1 1 1 1 Fungal cellulose binding domain TauD PF02668.11 EWC46460.1 - 4.6e-17 62.5 0.1 8.9e-17 61.6 0.1 1.4 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family CP_ATPgrasp_2 PF14403.1 EWC46460.1 - 0.0015 17.2 0.0 0.2 10.2 0.0 2.1 2 0 0 2 2 2 2 Circularly permuted ATP-grasp type 2 CsiD PF08943.5 EWC46460.1 - 0.0062 15.4 0.0 0.0093 14.8 0.0 1.2 1 0 0 1 1 1 1 CsiD ABC_tran PF00005.22 EWC46461.1 - 6.8e-49 165.6 0.0 3.9e-25 88.7 0.0 2.4 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.18 EWC46461.1 - 1.5e-29 103.3 15.0 1.5e-29 103.3 10.4 1.8 2 0 0 2 2 2 1 ABC transporter transmembrane region AAA_21 PF13304.1 EWC46461.1 - 1.3e-11 45.0 0.3 0.12 12.3 0.4 4.3 3 1 0 3 3 3 3 AAA domain SMC_N PF02463.14 EWC46461.1 - 1.8e-11 43.7 0.7 0.013 14.7 0.6 4.2 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_25 PF13481.1 EWC46461.1 - 4.6e-07 29.4 0.2 0.00088 18.7 0.0 2.9 3 0 0 3 3 3 2 AAA domain AAA_29 PF13555.1 EWC46461.1 - 5.3e-07 29.0 1.2 0.014 14.8 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.1 EWC46461.1 - 2.3e-06 27.7 0.1 0.079 12.9 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.1 EWC46461.1 - 3.2e-06 27.3 0.2 0.035 14.2 0.1 3.0 2 1 0 2 2 2 2 AAA domain Miro PF08477.8 EWC46461.1 - 1e-05 26.0 0.4 0.46 10.9 0.1 3.2 3 0 0 3 3 3 2 Miro-like protein DUF258 PF03193.11 EWC46461.1 - 3.5e-05 23.0 0.8 0.009 15.2 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA PF00004.24 EWC46461.1 - 5.7e-05 23.3 0.1 0.074 13.2 0.0 3.4 2 2 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.1 EWC46461.1 - 9.8e-05 22.2 0.0 0.037 13.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain PduV-EutP PF10662.4 EWC46461.1 - 0.00082 18.8 1.4 0.00095 18.6 0.1 1.7 2 0 0 2 2 1 1 Ethanolamine utilisation - propanediol utilisation AAA_17 PF13207.1 EWC46461.1 - 0.0017 19.1 0.1 2.8 8.7 0.0 2.9 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.18 EWC46461.1 - 0.0021 18.0 0.2 0.9 9.5 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase FtsK_SpoIIIE PF01580.13 EWC46461.1 - 0.0053 16.2 0.1 1.8 8.0 0.0 2.4 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_10 PF12846.2 EWC46461.1 - 0.0059 16.0 1.8 0.3 10.4 0.0 2.4 2 0 0 2 2 2 1 AAA-like domain AAA_5 PF07728.9 EWC46461.1 - 0.0081 15.8 0.7 0.61 9.8 0.0 3.4 3 1 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.1 EWC46461.1 - 0.0088 15.9 0.1 0.064 13.1 0.0 2.4 3 0 0 3 3 2 1 AAA domain ATP-synt_ab PF00006.20 EWC46461.1 - 0.011 15.2 0.1 0.047 13.1 0.0 2.0 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_23 PF13476.1 EWC46461.1 - 0.012 16.0 0.2 0.63 10.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.8 EWC46461.1 - 0.012 14.5 0.0 4.8 6.0 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF815) RNA_helicase PF00910.17 EWC46461.1 - 0.022 14.8 2.4 2.3 8.4 0.0 3.3 3 0 0 3 3 2 0 RNA helicase MobB PF03205.9 EWC46461.1 - 0.03 14.0 1.5 4.1 7.1 0.1 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B DUF3290 PF11694.3 EWC46461.1 - 0.045 13.4 4.6 0.071 12.8 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3290) NACHT PF05729.7 EWC46461.1 - 0.048 13.3 2.2 0.39 10.3 0.2 2.5 2 0 0 2 2 2 0 NACHT domain Arch_ATPase PF01637.13 EWC46461.1 - 0.084 12.5 0.1 0.32 10.6 0.0 2.0 2 0 0 2 2 1 0 Archaeal ATPase ArgK PF03308.11 EWC46461.1 - 0.13 11.0 0.3 4.7 5.9 0.0 2.2 2 0 0 2 2 2 0 ArgK protein DUF87 PF01935.12 EWC46461.1 - 0.22 11.2 1.6 0.34 10.6 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function DUF87 AAA_PrkA PF08298.6 EWC46461.1 - 0.27 9.8 0.1 1.3 7.5 0.0 2.0 2 0 0 2 2 2 0 PrkA AAA domain Rad17 PF03215.10 EWC46461.1 - 0.28 9.8 1.8 0.54 8.8 0.0 2.3 3 0 0 3 3 3 0 Rad17 cell cycle checkpoint protein Septin PF00735.13 EWC46461.1 - 0.42 9.5 0.8 2.8 6.8 0.1 2.1 2 0 0 2 2 2 0 Septin cobW PF02492.14 EWC46461.1 - 0.42 10.0 3.8 0.14 11.6 0.3 1.9 2 0 0 2 2 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.1 EWC46461.1 - 0.58 10.4 2.5 22 5.3 0.1 2.6 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.10 EWC46461.1 - 0.73 9.5 2.2 31 4.2 0.0 2.7 3 0 0 3 3 3 0 NTPase AAA_24 PF13479.1 EWC46461.1 - 5.1 6.6 5.4 22 4.5 0.4 2.8 2 1 1 3 3 3 0 AAA domain AMP-binding PF00501.23 EWC46462.1 - 0.029 12.7 0.0 0.078 11.3 0.0 1.6 1 1 0 1 1 1 0 AMP-binding enzyme PAS_9 PF13426.1 EWC46465.1 - 7.2e-19 68.0 0.0 2.4e-16 59.9 0.0 2.6 2 0 0 2 2 2 2 PAS domain PAS PF00989.19 EWC46465.1 - 9e-05 22.2 0.0 0.00025 20.8 0.0 1.8 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.5 EWC46465.1 - 0.00026 20.9 0.0 0.2 11.6 0.0 2.7 2 0 0 2 2 2 2 PAS fold DEAD PF00270.24 EWC46466.1 - 2.1e-44 151.0 0.0 6.9e-44 149.3 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EWC46466.1 - 1.8e-27 94.9 0.0 6.6e-27 93.1 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_19 PF13245.1 EWC46466.1 - 0.0067 16.1 0.4 0.034 13.8 0.1 2.3 2 0 0 2 2 2 1 Part of AAA domain AAA_22 PF13401.1 EWC46466.1 - 0.054 13.6 0.1 0.26 11.4 0.0 2.1 2 1 0 2 2 2 0 AAA domain CMS1 PF14617.1 EWC46466.1 - 1.2 8.1 0.0 1.2 8.1 0.0 4.7 4 1 1 5 5 5 0 U3-containing 90S pre-ribosomal complex subunit CSTF2_hinge PF14327.1 EWC46467.1 - 6.5e-29 99.8 2.7 6.5e-29 99.8 1.9 2.4 2 0 0 2 2 2 1 Hinge domain of cleavage stimulation factor subunit 2 RRM_1 PF00076.17 EWC46467.1 - 1.3e-20 72.7 0.0 2e-20 72.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EWC46467.1 - 3.2e-15 55.8 0.0 5.9e-15 54.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) CSTF_C PF14304.1 EWC46467.1 - 2.8e-11 42.5 7.7 8.3e-11 40.9 5.3 1.9 1 0 0 1 1 1 1 Transcription termination and cleavage factor C-terminal RRM_5 PF13893.1 EWC46467.1 - 1.1e-08 34.7 0.0 1.6e-08 34.2 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PPP1R35_C PF15503.1 EWC46467.1 - 0.13 11.7 1.8 0.21 11.1 1.2 1.2 1 0 0 1 1 1 0 Protein phosphatase 1 regulatory subunit 35 C-terminus ThiF PF00899.16 EWC46468.1 - 6.2e-27 94.0 0.0 1e-26 93.3 0.0 1.4 1 0 0 1 1 1 1 ThiF family 2-Hacid_dh_C PF02826.14 EWC46468.1 - 0.026 13.7 0.0 0.72 8.9 0.0 2.2 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.15 EWC46468.1 - 0.049 13.7 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NACHT PF05729.7 EWC46469.1 - 2e-06 27.5 0.0 5.7e-06 26.0 0.0 1.8 1 1 0 1 1 1 1 NACHT domain AAA_16 PF13191.1 EWC46469.1 - 1.1e-05 25.4 0.0 3.8e-05 23.7 0.0 1.9 1 0 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.17 EWC46469.1 - 4.2e-05 22.5 0.0 8e-05 21.6 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain AAA_17 PF13207.1 EWC46469.1 - 0.0085 16.9 0.1 0.1 13.4 0.0 2.8 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.1 EWC46469.1 - 0.013 15.6 0.0 0.043 13.9 0.0 2.0 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.1 EWC46469.1 - 0.021 14.6 0.2 0.066 13.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain APS_kinase PF01583.15 EWC46469.1 - 0.03 13.9 0.0 0.063 12.9 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_18 PF13238.1 EWC46469.1 - 0.042 14.1 0.0 0.14 12.4 0.0 2.0 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 EWC46469.1 - 0.081 13.1 0.0 0.18 11.9 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_30 PF13604.1 EWC46469.1 - 0.12 11.8 0.0 0.26 10.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain Ribosomal_L18e PF00828.14 EWC46470.1 - 1.7e-25 89.8 0.0 1.7e-25 89.8 0.0 1.7 2 0 0 2 2 2 1 Ribosomal protein L18e/L15 ADC PF06314.6 EWC46471.1 - 0.00034 20.0 0.0 0.00057 19.3 0.0 1.3 1 0 0 1 1 1 1 Acetoacetate decarboxylase (ADC) TBCA PF02970.11 EWC46472.1 - 3.7e-25 87.8 10.5 4.7e-25 87.4 7.3 1.2 1 0 0 1 1 1 1 Tubulin binding cofactor A Spc7 PF08317.6 EWC46472.1 - 0.017 13.8 5.3 0.019 13.6 3.7 1.0 1 0 0 1 1 1 0 Spc7 kinetochore protein FIVAR PF07554.8 EWC46472.1 - 0.068 13.4 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised Sugar-binding Domain DUF342 PF03961.8 EWC46472.1 - 0.18 10.2 2.1 0.21 9.9 1.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DUF2361 PF10153.4 EWC46472.1 - 0.36 11.0 5.6 0.43 10.7 3.8 1.1 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2361) FliJ PF02050.11 EWC46472.1 - 0.37 10.8 7.7 0.48 10.4 5.3 1.1 1 0 0 1 1 1 0 Flagellar FliJ protein Spectrin PF00435.16 EWC46472.1 - 3.2 8.0 8.2 0.76 10.1 1.1 2.0 1 1 1 2 2 2 0 Spectrin repeat Lge1 PF11488.3 EWC46472.1 - 5.8 7.1 7.7 34 4.7 5.3 1.9 1 1 0 1 1 1 0 Transcriptional regulatory protein LGE1 NifU_N PF01592.11 EWC46473.1 - 1.1e-43 148.2 0.2 1.2e-43 148.0 0.1 1.0 1 0 0 1 1 1 1 NifU-like N terminal domain Mito_carr PF00153.22 EWC46474.1 - 6.2e-75 247.0 1.7 7.4e-25 86.4 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Ppx-GppA PF02541.11 EWC46475.1 - 1.9e-43 148.7 0.0 3e-43 148.0 0.0 1.2 1 0 0 1 1 1 1 Ppx/GppA phosphatase family GDA1_CD39 PF01150.12 EWC46475.1 - 0.28 9.6 0.1 0.46 8.9 0.1 1.3 1 0 0 1 1 1 0 GDA1/CD39 (nucleoside phosphatase) family UCH PF00443.24 EWC46476.1 - 1.7e-39 135.5 0.0 2.6e-39 134.9 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.14 EWC46476.1 - 2.5e-22 78.7 6.2 7.4e-18 64.4 1.8 2.9 2 0 0 2 2 2 2 Zn-finger in ubiquitin-hydrolases and other protein UBA PF00627.26 EWC46476.1 - 5.2e-20 70.6 3.0 1e-11 44.3 0.0 3.0 3 0 0 3 3 3 2 UBA/TS-N domain UCH_1 PF13423.1 EWC46476.1 - 4.6e-15 55.8 0.0 5.2e-13 49.1 0.0 3.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UBA_4 PF14555.1 EWC46476.1 - 0.0036 16.8 0.0 0.0067 15.9 0.0 1.4 1 0 0 1 1 1 1 UBA-like domain zf-UBR PF02207.15 EWC46476.1 - 7.4 6.3 18.6 0.27 10.9 0.3 4.7 5 0 0 5 5 5 0 Putative zinc finger in N-recognin (UBR box) DLH PF01738.13 EWC46477.1 - 9.7e-14 51.1 0.0 4.8e-11 42.3 0.0 2.1 2 0 0 2 2 2 2 Dienelactone hydrolase family Hexokinase_2 PF03727.11 EWC46478.1 - 1e-89 299.9 0.0 1.4e-89 299.5 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.16 EWC46478.1 - 5.4e-75 251.2 0.1 8.8e-75 250.5 0.1 1.3 1 0 0 1 1 1 1 Hexokinase RRM_1 PF00076.17 EWC46479.1 - 3.5e-17 61.8 1.1 4.8e-17 61.3 0.3 1.6 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EWC46479.1 - 3.7e-12 46.0 0.0 6.1e-12 45.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EWC46479.1 - 8.2e-10 38.3 0.2 1.5e-09 37.5 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DPCD PF14913.1 EWC46479.1 - 0.054 12.6 0.1 0.08 12.0 0.0 1.2 1 0 0 1 1 1 0 DPCD protein family Ribophorin_I PF04597.9 EWC46480.1 - 7.1e-143 476.2 0.0 8e-143 476.0 0.0 1.0 1 0 0 1 1 1 1 Ribophorin I Indigoidine_A PF04227.7 EWC46481.1 - 1.6e-100 336.1 0.3 2.5e-100 335.5 0.2 1.3 1 0 0 1 1 1 1 Indigoidine synthase A like protein PfkB PF00294.19 EWC46481.1 - 3.4e-19 69.1 1.3 1.6e-11 43.9 0.0 3.3 3 0 0 3 3 3 2 pfkB family carbohydrate kinase MSC PF09402.5 EWC46482.1 - 1.3e-82 277.1 0.4 1.9e-82 276.6 0.2 1.2 1 0 0 1 1 1 1 Man1-Src1p-C-terminal domain HeH PF12949.2 EWC46482.1 - 9.4e-12 44.2 0.1 1.9e-11 43.3 0.1 1.5 1 0 0 1 1 1 1 HeH/LEM domain Endonuc-dimeris PF09124.5 EWC46482.1 - 0.059 13.0 0.1 0.37 10.4 0.0 2.2 2 0 0 2 2 2 0 T4 recombination endonuclease VII, dimerisation Glyco_hydro_18 PF00704.23 EWC46483.1 - 2.6e-79 267.1 1.9 3.6e-79 266.7 1.3 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 DNase_NucA_NucB PF14040.1 EWC46483.1 - 0.0004 20.5 0.1 0.011 15.8 0.0 2.8 2 1 0 2 2 2 1 Deoxyribonuclease NucA/NucB LysM PF01476.15 EWC46484.1 - 0.0065 16.3 0.6 0.069 13.0 0.0 2.6 2 0 0 2 2 2 1 LysM domain LysM PF01476.15 EWC46485.1 - 5.2e-25 87.0 0.2 0.01 15.7 0.0 6.3 6 0 0 6 6 6 6 LysM domain VBS PF08913.5 EWC46485.1 - 0.079 13.2 0.0 79 3.5 0.0 3.3 3 0 0 3 3 3 0 Vinculin Binding Site HSP20 PF00011.16 EWC46487.1 - 1.4e-17 63.4 0.4 3.6e-13 49.2 0.0 2.1 2 0 0 2 2 2 2 Hsp20/alpha crystallin family Rft-1 PF04506.8 EWC46488.1 - 4.4e-92 309.2 0.0 1.9e-54 184.9 0.0 2.1 2 0 0 2 2 2 2 Rft protein Polysacc_synt PF01943.12 EWC46488.1 - 0.0031 16.8 2.8 0.042 13.1 0.2 3.7 5 0 0 5 5 5 2 Polysaccharide biosynthesis protein RseC_MucC PF04246.7 EWC46488.1 - 2 7.9 7.1 0.27 10.7 0.2 3.0 3 0 0 3 3 3 0 Positive regulator of sigma(E), RseC/MucC HAD_2 PF13419.1 EWC46489.1 - 2.1e-11 44.3 0.0 6.2e-11 42.8 0.0 1.7 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 EWC46489.1 - 3e-09 36.4 0.2 5.6e-09 35.5 0.1 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.21 EWC46489.1 - 1.5e-07 32.0 0.0 2.1e-07 31.6 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase DBD_Tnp_Hermes PF10683.4 EWC46489.1 - 0.049 13.1 0.4 0.09 12.2 0.3 1.4 1 0 0 1 1 1 0 Hermes transposase DNA-binding domain Glyco_trans_1_4 PF13692.1 EWC46490.1 - 0.0021 18.1 0.0 0.0053 16.9 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 DUF3470 PF11953.3 EWC46490.1 - 0.033 13.7 0.2 0.12 11.9 0.1 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3470) Herpes_UL14 PF03580.9 EWC46491.1 - 0.069 12.9 1.7 0.08 12.7 0.2 1.8 2 0 0 2 2 2 0 Herpesvirus UL14-like protein dsDNA_bind PF01984.15 EWC46493.1 - 0.17 11.9 15.9 0.55 10.2 11.0 1.9 1 0 0 1 1 1 0 Double-stranded DNA-binding domain DUF1515 PF07439.6 EWC46493.1 - 1.8 8.3 5.3 0.96 9.2 1.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1515) IncA PF04156.9 EWC46493.1 - 4.5 6.8 32.3 1.2 8.7 10.1 2.9 3 0 0 3 3 3 0 IncA protein Tweety PF04906.8 EWC46493.1 - 10 4.4 7.2 16 3.7 0.1 2.1 2 0 0 2 2 2 0 Tweety CHAT PF12770.2 EWC46494.1 - 5.5e-32 111.0 0.0 9e-32 110.3 0.0 1.4 1 0 0 1 1 1 1 CHAT domain TPR_12 PF13424.1 EWC46494.1 - 1.5e-10 40.8 0.8 0.0096 15.8 0.1 6.3 2 2 3 6 6 6 2 Tetratricopeptide repeat TPR_11 PF13414.1 EWC46494.1 - 8.6e-06 25.3 1.4 0.023 14.3 0.0 4.9 5 0 0 5 5 5 1 TPR repeat TPR_2 PF07719.12 EWC46494.1 - 0.025 14.4 1.4 24 5.1 0.0 5.3 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_17 PF13431.1 EWC46494.1 - 0.11 12.7 0.2 1.8 8.9 0.1 3.1 2 1 1 3 3 3 0 Tetratricopeptide repeat zf-C4H2 PF10146.4 EWC46494.1 - 0.14 12.1 0.2 0.88 9.5 0.2 2.2 2 1 0 2 2 2 0 Zinc finger-containing protein TPR_1 PF00515.23 EWC46494.1 - 0.29 10.8 4.0 4.2 7.1 0.0 4.3 6 0 0 6 6 6 0 Tetratricopeptide repeat Peptidase_C14 PF00656.17 EWC46495.1 - 5.3e-17 62.3 0.0 9.3e-17 61.5 0.0 1.4 1 0 0 1 1 1 1 Caspase domain PNP_UDP_1 PF01048.15 EWC46496.1 - 3.3e-11 42.6 0.2 1.4e-10 40.6 0.1 1.9 1 1 0 1 1 1 1 Phosphorylase superfamily RrnaAD PF00398.15 EWC46497.1 - 1.3e-58 198.1 0.0 1.7e-58 197.6 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_26 PF13659.1 EWC46497.1 - 1.7e-08 34.5 0.0 3.8e-08 33.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EWC46497.1 - 1.3e-06 28.9 0.0 3.3e-06 27.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EWC46497.1 - 9.2e-05 22.0 0.0 0.00015 21.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EWC46497.1 - 0.00024 20.5 0.0 0.00039 19.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_23 PF13489.1 EWC46497.1 - 0.00026 20.7 0.0 0.00053 19.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 EWC46497.1 - 0.00029 20.4 0.0 0.00053 19.5 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.15 EWC46497.1 - 0.0011 18.1 0.0 0.0018 17.4 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.7 EWC46497.1 - 0.0017 18.8 0.0 0.0037 17.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EWC46497.1 - 0.0067 15.5 0.0 0.011 14.9 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Met_10 PF02475.11 EWC46497.1 - 0.011 15.3 0.0 0.017 14.7 0.0 1.3 1 0 0 1 1 1 0 Met-10+ like-protein Methyltransf_25 PF13649.1 EWC46497.1 - 0.048 14.0 0.0 0.11 12.8 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain DREV PF05219.7 EWC46497.1 - 0.1 11.4 0.0 0.21 10.4 0.0 1.4 1 0 0 1 1 1 0 DREV methyltransferase PRP1_N PF06424.7 EWC46498.1 - 1.9e-51 173.8 6.0 4.8e-51 172.5 4.2 1.7 1 0 0 1 1 1 1 PRP1 splicing factor, N-terminal TPR_14 PF13428.1 EWC46498.1 - 3.5e-24 83.0 39.9 0.012 16.2 0.1 14.2 5 3 9 14 14 14 9 Tetratricopeptide repeat TPR_19 PF14559.1 EWC46498.1 - 6.6e-21 74.4 24.1 4e-05 23.8 0.3 10.0 7 3 3 10 10 10 6 Tetratricopeptide repeat TPR_16 PF13432.1 EWC46498.1 - 5.2e-16 58.8 33.3 0.0014 19.2 0.5 8.5 7 1 0 8 8 8 6 Tetratricopeptide repeat TPR_2 PF07719.12 EWC46498.1 - 5.5e-08 32.1 15.1 0.7 9.9 0.0 9.0 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_11 PF13414.1 EWC46498.1 - 1.6e-06 27.6 26.1 0.08 12.5 0.0 8.2 5 3 4 9 9 9 4 TPR repeat Suf PF05843.9 EWC46498.1 - 0.00058 19.6 0.7 2.3 7.8 0.0 4.2 5 1 1 6 6 6 2 Suppressor of forked protein (Suf) TPR_12 PF13424.1 EWC46498.1 - 0.0011 18.8 8.9 2.8 7.9 0.0 6.1 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_1 PF00515.23 EWC46498.1 - 0.0038 16.7 1.3 0.63 9.7 0.0 3.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.1 EWC46498.1 - 0.0092 15.7 1.8 21 5.1 0.0 5.3 6 0 0 6 6 6 0 Tetratricopeptide repeat NARP1 PF12569.3 EWC46498.1 - 0.017 13.8 9.2 0.083 11.6 0.0 4.1 3 1 1 4 4 4 0 NMDA receptor-regulated protein 1 TPR_9 PF13371.1 EWC46498.1 - 1.1 9.1 10.2 4.9 7.0 0.1 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat Galactosyl_T PF01762.16 EWC46499.1 - 0.042 13.4 0.0 0.094 12.3 0.0 1.5 1 0 0 1 1 1 0 Galactosyltransferase dCMP_cyt_deam_1 PF00383.17 EWC46500.1 - 7.7e-18 64.0 0.0 1.1e-17 63.5 0.0 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region AAA_17 PF13207.1 EWC46500.1 - 0.00012 22.8 0.0 0.00031 21.5 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 EWC46500.1 - 0.038 14.2 0.1 0.19 12.0 0.1 2.0 1 1 0 1 1 1 0 AAA domain CoaE PF01121.15 EWC46500.1 - 0.11 11.8 0.1 0.19 11.0 0.0 1.3 1 0 0 1 1 1 0 Dephospho-CoA kinase Ribosomal_S4 PF00163.14 EWC46501.1 - 2.1e-15 56.8 0.7 4.6e-15 55.7 0.6 1.5 2 0 0 2 2 2 1 Ribosomal protein S4/S9 N-terminal domain S4 PF01479.20 EWC46501.1 - 3.3e-12 45.6 0.0 6e-12 44.7 0.0 1.4 1 0 0 1 1 1 1 S4 domain ADP_ribosyl_GH PF03747.9 EWC46502.1 - 1.5e-56 192.2 0.3 1.9e-56 191.9 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase Gly-zipper_Omp PF13488.1 EWC46502.1 - 0.034 13.7 3.2 0.49 10.0 2.0 2.3 2 0 0 2 2 2 0 Glycine zipper Gly-zipper_YMGG PF13441.1 EWC46502.1 - 0.26 10.8 5.1 0.88 9.1 1.7 2.4 2 0 0 2 2 2 0 YMGG-like Gly-zipper Rick_17kDa_Anti PF05433.10 EWC46502.1 - 1.6 8.4 8.6 0.096 12.3 1.5 2.1 2 0 0 2 2 2 0 Glycine zipper 2TM domain Gly-zipper_OmpA PF13436.1 EWC46502.1 - 2.3 7.9 4.9 4.2 7.0 1.3 2.7 2 1 0 2 2 2 0 Glycine-zipper containing OmpA-like membrane domain TRP PF06011.7 EWC46503.1 - 3.1e-125 418.2 14.8 3.9e-125 417.8 10.3 1.0 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.1 EWC46503.1 - 3.1e-34 118.0 0.0 4.9e-34 117.3 0.0 1.3 1 0 0 1 1 1 1 ML-like domain gpUL132 PF11359.3 EWC46503.1 - 0.1 11.9 1.0 1 8.6 0.0 2.7 3 0 0 3 3 3 0 Glycoprotein UL132 FAM176 PF14851.1 EWC46503.1 - 0.21 11.2 0.0 0.5 10.0 0.0 1.5 1 0 0 1 1 1 0 FAM176 family DWNN PF08783.6 EWC46504.1 - 1e-25 89.4 0.0 2.1e-25 88.4 0.0 1.5 1 0 0 1 1 1 1 DWNN domain zf-CCHC PF00098.18 EWC46504.1 - 8.4e-05 22.3 2.1 0.00019 21.1 1.4 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.1 EWC46504.1 - 0.00019 20.8 5.2 0.00055 19.3 3.6 1.8 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_3 PF13917.1 EWC46504.1 - 0.0012 18.4 0.3 0.0032 17.1 0.2 1.6 1 0 0 1 1 1 1 Zinc knuckle U-box PF04564.10 EWC46504.1 - 0.014 15.3 0.0 0.034 14.0 0.0 1.7 1 0 0 1 1 1 0 U-box domain zf-CCHC_5 PF14787.1 EWC46504.1 - 0.12 11.8 2.0 0.41 10.1 0.2 2.3 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger zf-C3HC4_2 PF13923.1 EWC46504.1 - 0.36 10.9 13.8 0.053 13.5 5.3 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EWC46504.1 - 1.1 9.1 12.3 0.019 14.7 3.6 1.8 2 0 0 2 2 2 0 Ring finger domain zf-C3HC4_3 PF13920.1 EWC46504.1 - 1.4 8.6 10.4 0.24 11.1 3.5 2.0 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EWC46504.1 - 1.5 8.5 7.9 3.2 7.5 5.5 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EWC46504.1 - 2.3 8.0 12.4 0.15 11.8 4.4 2.0 2 0 0 2 2 2 0 zinc-RING finger domain BMF PF15185.1 EWC46505.1 - 0.0043 16.3 1.3 0.0088 15.3 0.9 1.5 1 0 0 1 1 1 1 Bcl-2-modifying factor, apoptosis DUF3682 PF12446.3 EWC46505.1 - 0.028 14.7 5.0 0.055 13.7 3.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) Vac7 PF12751.2 EWC46506.1 - 5.6e-68 229.5 9.5 5.6e-68 229.5 6.6 2.4 1 1 1 2 2 2 1 Vacuolar segregation subunit 7 Protoglobin PF11563.3 EWC46507.1 - 2.1e-48 163.9 0.0 2.5e-48 163.6 0.0 1.1 1 0 0 1 1 1 1 Protoglobin Pkinase PF00069.20 EWC46508.1 - 1.9e-47 161.6 0.0 8.1e-47 159.5 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC46508.1 - 6.2e-29 100.8 0.0 1.3e-28 99.7 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.6 EWC46508.1 - 0.12 11.1 0.1 0.19 10.4 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase WD40 PF00400.27 EWC46509.1 - 1.4e-59 196.0 16.5 4.2e-10 39.1 0.1 11.4 12 0 0 12 12 12 10 WD domain, G-beta repeat Coatomer_WDAD PF04053.9 EWC46509.1 - 8.5e-06 24.8 0.1 0.0056 15.5 0.0 2.5 2 1 0 2 2 2 2 Coatomer WD associated region Apc4_WD40 PF12894.2 EWC46509.1 - 0.00013 21.3 0.0 0.48 9.9 0.0 3.4 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Ricin_B_lectin PF00652.17 EWC46509.1 - 0.0054 16.7 0.4 0.13 12.2 0.1 3.0 4 0 0 4 4 4 1 Ricin-type beta-trefoil lectin domain PD40 PF07676.7 EWC46509.1 - 0.011 15.3 0.7 8.7 6.1 0.0 4.2 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat DUF3312 PF11768.3 EWC46509.1 - 0.016 13.4 0.0 3.4 5.7 0.0 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF3312) RAB3GAP2_N PF14655.1 EWC46509.1 - 0.031 13.2 0.0 0.078 11.9 0.0 1.7 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus FtsJ PF01728.14 EWC46511.1 - 2.3e-54 184.1 0.0 3.1e-54 183.6 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_23 PF13489.1 EWC46511.1 - 0.047 13.4 0.0 0.078 12.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Filament PF00038.16 EWC46512.1 - 8.2e-06 25.4 75.3 0.00021 20.8 31.4 3.3 1 1 2 3 3 3 3 Intermediate filament protein AAA_13 PF13166.1 EWC46512.1 - 0.00044 18.8 32.5 0.00044 18.8 22.5 3.3 1 1 2 3 3 3 3 AAA domain WEMBL PF05701.6 EWC46512.1 - 0.00055 18.5 30.6 0.00055 18.5 21.2 3.6 1 1 2 3 3 3 2 Weak chloroplast movement under blue light Spc7 PF08317.6 EWC46512.1 - 0.00081 18.1 25.0 0.00081 18.1 17.3 3.7 1 1 3 4 4 3 1 Spc7 kinetochore protein CENP-F_leu_zip PF10473.4 EWC46512.1 - 0.001 18.9 27.2 0.001 18.9 18.9 5.7 1 1 4 5 5 5 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GAS PF13851.1 EWC46512.1 - 0.0029 16.8 12.5 0.0029 16.8 8.7 5.8 1 1 5 6 6 6 3 Growth-arrest specific micro-tubule binding Reo_sigmaC PF04582.7 EWC46512.1 - 0.0068 15.6 6.8 0.0068 15.6 4.7 3.8 1 1 3 4 4 4 1 Reovirus sigma C capsid protein FliJ PF02050.11 EWC46512.1 - 0.014 15.4 63.9 0.026 14.5 5.8 4.8 2 1 2 4 4 4 0 Flagellar FliJ protein TPR_MLP1_2 PF07926.7 EWC46512.1 - 0.33 10.7 92.8 0.2 11.4 6.5 5.7 1 1 4 5 5 5 0 TPR/MLP1/MLP2-like protein TBPIP PF07106.8 EWC46512.1 - 0.35 10.3 65.9 0.06 12.9 7.7 5.2 1 1 4 5 5 5 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) IncA PF04156.9 EWC46512.1 - 0.36 10.4 83.7 0.21 11.1 15.0 4.5 1 1 3 4 4 4 0 IncA protein DUF869 PF05911.6 EWC46512.1 - 0.45 8.6 72.9 0.069 11.3 10.6 3.9 1 1 3 4 4 4 0 Plant protein of unknown function (DUF869) Myosin_tail_1 PF01576.14 EWC46512.1 - 0.85 7.2 90.6 0.011 13.4 34.4 2.3 1 1 1 2 2 2 0 Myosin tail Matrilin_ccoil PF10393.4 EWC46512.1 - 2.9 7.3 12.3 1.7 8.0 1.2 4.1 3 1 1 4 4 4 0 Trimeric coiled-coil oligomerisation domain of matrilin Laminin_II PF06009.7 EWC46512.1 - 3.9 7.2 52.6 0.48 10.1 9.2 5.0 1 1 5 6 6 6 0 Laminin Domain II MAD PF05557.8 EWC46512.1 - 7 4.6 81.7 0.026 12.6 27.0 2.9 1 1 2 3 3 3 0 Mitotic checkpoint protein OST3_OST6 PF04756.8 EWC46513.1 - 1.3e-22 80.0 3.2 1.9e-22 79.5 2.2 1.3 1 0 0 1 1 1 1 OST3 / OST6 family Use1 PF09753.4 EWC46513.1 - 0.44 9.9 2.9 0.65 9.3 2.0 1.2 1 0 0 1 1 1 0 Membrane fusion protein Use1 SAGA-Tad1 PF12767.2 EWC46514.1 - 8e-37 127.2 0.0 1.2e-36 126.6 0.0 1.2 1 0 0 1 1 1 1 Transcriptional regulator of RNA polII, SAGA, subunit DUF3677 PF12432.3 EWC46514.1 - 0.057 13.8 0.0 0.14 12.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3677) SNF2_N PF00176.18 EWC46515.1 - 3.7e-68 229.5 0.0 6.3e-68 228.7 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 EWC46515.1 - 4.3e-14 52.1 0.0 1.1e-13 50.8 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EWC46515.1 - 2.8e-11 43.5 0.3 1.2e-10 41.4 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.3 EWC46515.1 - 9.5e-05 21.3 0.0 0.00039 19.3 0.0 1.9 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 FCD PF07729.7 EWC46515.1 - 0.055 13.8 0.1 0.055 13.8 0.0 2.9 4 0 0 4 4 4 0 FCD domain AAA_11 PF13086.1 EWC46515.1 - 0.12 11.8 4.7 0.25 10.8 0.1 3.1 2 1 0 2 2 2 0 AAA domain FUSC_2 PF13515.1 EWC46516.1 - 3.8e-26 91.5 4.1 3.8e-26 91.5 2.8 2.4 2 0 0 2 2 2 1 Fusaric acid resistance protein-like FUSC PF04632.7 EWC46516.1 - 5.9e-14 51.4 3.0 3.3e-13 48.9 0.1 2.5 2 0 0 2 2 2 1 Fusaric acid resistance protein family DUF2421 PF10334.4 EWC46516.1 - 1.4e-11 44.4 0.2 4.1e-10 39.6 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF2421) ALMT PF11744.3 EWC46516.1 - 1.1e-09 37.5 12.6 9.3e-06 24.5 4.9 3.7 4 1 0 4 4 4 2 Aluminium activated malate transporter FUSC-like PF12805.2 EWC46516.1 - 3.5 6.4 7.1 3.7 6.3 0.6 2.9 2 0 0 2 2 2 0 FUSC-like inner membrane protein yccS Aminotran_1_2 PF00155.16 EWC46517.1 - 7.6e-36 123.8 0.0 9.6e-36 123.4 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Sua5_yciO_yrdC PF01300.13 EWC46517.1 - 0.1 11.8 0.0 0.2 10.8 0.0 1.5 1 0 0 1 1 1 0 Telomere recombination DUF727 PF05303.7 EWC46518.1 - 5.1e-08 32.6 0.0 6.1e-08 32.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF727) MVP_shoulder PF11978.3 EWC46518.1 - 0.064 13.1 0.0 0.092 12.6 0.0 1.3 1 0 0 1 1 1 0 Shoulder domain His_biosynth PF00977.16 EWC46520.1 - 2.3e-48 164.4 0.2 1.6e-47 161.7 0.1 2.3 1 1 0 1 1 1 1 Histidine biosynthesis protein GATase PF00117.23 EWC46520.1 - 1.5e-26 93.0 0.0 2.5e-26 92.2 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I SNO PF01174.14 EWC46520.1 - 3.4e-09 36.6 0.0 5.9e-06 26.0 0.0 2.3 2 0 0 2 2 2 2 SNO glutamine amidotransferase family GATase_3 PF07685.9 EWC46520.1 - 7.1e-07 28.9 0.2 3.1e-06 26.8 0.1 2.0 1 1 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain Peptidase_C26 PF07722.8 EWC46520.1 - 0.0094 15.4 0.0 0.017 14.5 0.0 1.4 1 0 0 1 1 1 1 Peptidase C26 Peptidase_S8 PF00082.17 EWC46521.1 - 5e-40 137.4 0.6 7.1e-40 136.9 0.4 1.2 1 0 0 1 1 1 1 Subtilase family ODC_AZ PF02100.12 EWC46522.1 - 9.3e-23 79.8 0.0 3e-22 78.1 0.0 1.8 2 1 0 2 2 2 1 Ornithine decarboxylase antizyme Ribosomal_L7Ae PF01248.21 EWC46523.1 - 1.6e-25 88.4 0.0 1.8e-25 88.2 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Ribosomal_L16 PF00252.13 EWC46524.1 - 2.6e-31 108.1 0.1 3.3e-31 107.7 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e DUF2196 PF09962.4 EWC46525.1 - 3.4e-20 71.5 2.6 5.8e-20 70.8 1.8 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2196) zf-H2C2_5 PF13909.1 EWC46525.1 - 0.0026 17.8 0.1 0.0045 17.1 0.1 1.4 1 0 0 1 1 1 1 C2H2-type zinc-finger domain OB_NTP_bind PF07717.11 EWC46526.1 - 4.2e-30 103.8 0.0 1.8e-29 101.9 0.0 2.1 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.18 EWC46526.1 - 2.8e-25 88.2 0.1 2.8e-25 88.2 0.0 3.5 4 0 0 4 4 4 1 Helicase associated domain (HA2) Helicase_C PF00271.26 EWC46526.1 - 5.9e-13 48.4 0.6 3.3e-12 46.1 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_22 PF13401.1 EWC46526.1 - 8.4e-06 25.9 2.8 0.00018 21.6 0.0 3.3 3 0 0 3 3 3 1 AAA domain DEAD PF00270.24 EWC46526.1 - 2.4e-05 23.8 0.0 8e-05 22.1 0.0 1.9 1 0 0 1 1 1 1 DEAD/DEAH box helicase T2SE PF00437.15 EWC46526.1 - 0.00089 18.2 0.1 0.0026 16.7 0.0 1.7 2 0 0 2 2 2 1 Type II/IV secretion system protein PWI PF01480.12 EWC46526.1 - 0.014 15.5 0.0 0.036 14.1 0.0 1.7 1 0 0 1 1 1 0 PWI domain AAA_19 PF13245.1 EWC46526.1 - 0.021 14.5 0.3 0.28 10.9 0.1 2.7 3 0 0 3 3 3 0 Part of AAA domain Sigma54_activ_2 PF14532.1 EWC46526.1 - 0.037 14.0 0.1 0.14 12.1 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_11 PF13086.1 EWC46526.1 - 0.52 9.8 0.0 0.52 9.8 0.0 3.6 4 1 0 4 4 4 0 AAA domain SIS PF01380.17 EWC46527.1 - 2.4e-11 43.3 0.4 9.4e-11 41.4 0.3 2.0 1 1 0 1 1 1 1 SIS domain SIS_2 PF13580.1 EWC46527.1 - 4.6e-07 29.6 0.9 3.5e-05 23.5 0.1 2.3 1 1 1 2 2 2 2 SIS domain HTH_psq PF05225.11 EWC46527.1 - 0.54 9.8 3.5 0.76 9.3 0.0 2.7 2 1 1 3 3 3 0 helix-turn-helix, Psq domain Nop14 PF04147.7 EWC46528.1 - 0.0069 14.3 7.7 0.0097 13.8 5.4 1.2 1 0 0 1 1 1 1 Nop14-like family SDA1 PF05285.7 EWC46528.1 - 0.019 14.2 8.4 0.032 13.5 5.8 1.4 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.9 EWC46528.1 - 0.14 10.2 3.6 0.21 9.5 2.5 1.4 1 0 0 1 1 1 0 CDC45-like protein IFT57 PF10498.4 EWC46528.1 - 0.18 10.4 3.6 0.27 9.9 2.5 1.2 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 DNA_pol_viral_N PF00242.12 EWC46528.1 - 0.38 9.7 3.4 0.94 8.4 2.3 1.7 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain Med3 PF11593.3 EWC46528.1 - 9.3 5.3 17.8 15 4.7 0.4 2.4 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal Yippee-Mis18 PF03226.9 EWC46529.1 - 9.8e-21 73.6 0.1 1.8e-20 72.7 0.1 1.4 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Nop14 PF04147.7 EWC46529.1 - 0.051 11.4 2.6 0.088 10.7 1.8 1.3 1 0 0 1 1 1 0 Nop14-like family GFA PF04828.9 EWC46529.1 - 0.21 11.5 2.6 2.8 7.9 1.5 2.3 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme TMEM171 PF15471.1 EWC46529.1 - 3.5 6.3 5.7 5.5 5.6 4.0 1.2 1 0 0 1 1 1 0 Transmembrane protein family 171 DUF605 PF04652.11 EWC46529.1 - 5.2 6.3 13.0 7.1 5.9 9.0 1.1 1 0 0 1 1 1 0 Vta1 like SHNi-TPR PF10516.4 EWC46530.1 - 1.2e-14 53.2 0.3 3.5e-14 51.7 0.2 1.9 1 0 0 1 1 1 1 SHNi-TPR TPR_11 PF13414.1 EWC46530.1 - 0.002 17.7 7.2 0.13 11.9 0.1 3.3 2 1 0 2 2 2 2 TPR repeat V-SNARE PF05008.10 EWC46530.1 - 0.05 13.7 4.5 0.77 9.9 0.1 3.4 2 1 0 3 3 3 0 Vesicle transport v-SNARE protein N-terminus GAS PF13851.1 EWC46530.1 - 0.38 9.9 4.1 1.4 8.0 0.1 2.5 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding TPR_16 PF13432.1 EWC46530.1 - 1.3 9.7 12.0 0.75 10.5 4.7 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat RRM_1 PF00076.17 EWC46531.1 - 9.2e-37 124.5 0.1 2.3e-17 62.3 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EWC46531.1 - 6.1e-29 99.8 0.0 6.9e-14 51.5 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EWC46531.1 - 9e-15 54.2 0.0 1.4e-06 28.0 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 EWC46531.1 - 0.027 14.2 0.0 2.3 8.0 0.0 2.3 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.6 EWC46531.1 - 0.17 11.7 0.0 18 5.2 0.0 2.4 2 0 0 2 2 2 0 RNA binding motif MCRS_N PF13325.1 EWC46531.1 - 0.18 11.3 0.5 0.33 10.4 0.4 1.4 1 0 0 1 1 1 0 N-terminal region of micro-spherule protein RabGAP-TBC PF00566.13 EWC46532.1 - 2e-53 181.0 0.1 2.7e-53 180.5 0.0 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF1771 PF08590.5 EWC46532.1 - 0.034 14.1 0.2 0.061 13.3 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1771) Ribosomal_S18 PF01084.15 EWC46533.1 - 4.6e-16 58.4 0.2 1.3e-15 56.9 0.1 1.8 2 0 0 2 2 2 1 Ribosomal protein S18 PPR_2 PF13041.1 EWC46534.1 - 2.8e-10 39.9 8.0 0.018 14.9 0.1 5.8 6 0 0 6 6 6 3 PPR repeat family PPR_3 PF13812.1 EWC46534.1 - 2.5e-05 24.1 4.4 9.9 6.7 0.0 6.7 8 0 0 8 8 8 2 Pentatricopeptide repeat domain PPR PF01535.15 EWC46534.1 - 4.5e-05 23.1 4.4 0.12 12.4 0.2 4.3 5 0 0 5 5 5 2 PPR repeat PPR_1 PF12854.2 EWC46534.1 - 2.7 7.5 4.5 2.8 7.4 0.1 2.9 4 0 0 4 4 4 0 PPR repeat Cyt-b5 PF00173.23 EWC46535.1 - 4.5e-19 68.0 0.1 5e-19 67.8 0.1 1.0 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain V-ATPase_H_C PF11698.3 EWC46535.1 - 0.011 15.6 0.0 0.013 15.3 0.0 1.3 1 0 0 1 1 1 0 V-ATPase subunit H EFP_N PF08207.7 EWC46535.1 - 0.12 12.2 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 Elongation factor P (EF-P) KOW-like domain SWIM PF04434.12 EWC46536.1 - 0.054 12.9 0.7 3.7 7.1 0.2 2.4 2 0 0 2 2 2 0 SWIM zinc finger CorA PF01544.13 EWC46539.1 - 0.0073 15.3 3.6 0.023 13.7 2.2 2.1 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein DUF3980 PF13140.1 EWC46539.1 - 0.14 12.4 0.3 0.72 10.1 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3980) Pkinase PF00069.20 EWC46540.1 - 7.7e-37 126.8 0.1 8.4e-35 120.1 0.0 2.6 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 EWC46540.1 - 1.8e-24 86.2 0.0 2.2e-22 79.3 0.0 2.9 2 2 0 2 2 2 2 Protein tyrosine kinase Choline_kinase PF01633.15 EWC46540.1 - 0.02 14.5 0.0 0.056 13.0 0.0 1.7 1 0 0 1 1 1 0 Choline/ethanolamine kinase APH PF01636.18 EWC46540.1 - 0.077 12.7 0.0 0.23 11.1 0.0 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family DNA_pol_B PF00136.16 EWC46541.1 - 3e-146 487.9 2.4 4.2e-146 487.3 1.7 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.14 EWC46541.1 - 9.9e-81 271.1 0.1 2.3e-80 269.9 0.1 1.7 2 0 0 2 2 2 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.1 EWC46541.1 - 3.4e-24 84.6 7.8 3.4e-24 84.6 5.4 1.9 2 0 0 2 2 2 1 C4-type zinc-finger of DNA polymerase delta DNA_pol_B_exo2 PF10108.4 EWC46541.1 - 8e-05 22.2 0.0 0.00018 21.0 0.0 1.5 1 0 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.1 EWC46541.1 - 0.0051 16.6 1.2 0.016 15.0 0.2 2.5 2 1 0 2 2 2 1 RNase_H superfamily DUF2614 PF11023.3 EWC46541.1 - 0.042 13.6 0.3 0.088 12.5 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2614) DNA_pol_B_2 PF03175.8 EWC46541.1 - 0.13 10.9 6.0 0.54 8.8 0.1 3.5 4 0 0 4 4 4 0 DNA polymerase type B, organellar and viral F-box PF00646.28 EWC46542.1 - 8.4e-08 31.6 0.3 1.7e-07 30.7 0.2 1.4 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 EWC46542.1 - 0.00081 19.0 0.2 0.002 17.7 0.2 1.7 1 0 0 1 1 1 1 F-box-like Sigma70_ner PF04546.8 EWC46542.1 - 0.22 11.0 2.2 0.42 10.2 1.5 1.4 1 0 0 1 1 1 0 Sigma-70, non-essential region Nucleoplasmin PF03066.10 EWC46542.1 - 7.7 6.0 6.9 15 5.1 4.8 1.4 1 0 0 1 1 1 0 Nucleoplasmin Zip PF02535.17 EWC46543.1 - 3.3e-57 193.8 12.0 4.6e-57 193.4 8.3 1.2 1 0 0 1 1 1 1 ZIP Zinc transporter GFO_IDH_MocA PF01408.17 EWC46544.1 - 5e-11 43.1 0.3 2.7e-10 40.8 0.2 2.1 1 1 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold AMP-binding PF00501.23 EWC46544.1 - 0.0017 16.7 0.0 0.0027 16.1 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme DHDPS PF00701.17 EWC46545.1 - 2e-37 128.3 0.0 2.4e-37 128.1 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family EKR PF10371.4 EWC46546.1 - 0.11 12.0 0.0 0.16 11.5 0.0 1.4 2 0 0 2 2 2 0 Domain of unknown function Clr5 PF14420.1 EWC46547.1 - 2.8e-18 65.5 1.2 5.3e-18 64.6 0.8 1.5 1 0 0 1 1 1 1 Clr5 domain Ank_2 PF12796.2 EWC46547.1 - 1.7e-06 28.2 0.0 0.0034 17.6 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 EWC46547.1 - 6.4e-06 26.5 0.0 0.0073 16.7 0.0 2.4 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 EWC46547.1 - 4.5e-05 23.5 0.0 0.00088 19.4 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.25 EWC46547.1 - 0.036 13.8 0.6 1.7 8.6 0.0 2.9 3 0 0 3 3 3 0 Ankyrin repeat Ank_3 PF13606.1 EWC46547.1 - 0.048 13.9 0.2 22 5.6 0.0 3.3 4 0 0 4 4 4 0 Ankyrin repeat Glyco_hydro_3 PF00933.16 EWC46548.1 - 2e-83 279.8 0.0 2.9e-83 279.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.17 EWC46548.1 - 1.9e-55 187.8 0.0 6.3e-55 186.1 0.0 1.8 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.1 EWC46548.1 - 1e-16 60.6 0.5 2.2e-16 59.5 0.3 1.6 1 0 0 1 1 1 1 Fibronectin type III-like domain Fungal_trans PF04082.13 EWC46549.1 - 6.4e-40 136.6 0.0 1.1e-39 135.8 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EWC46549.1 - 7e-10 38.6 8.0 1.5e-09 37.5 5.5 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Cyanate_lyase PF02560.9 EWC46554.1 - 1.8e-31 107.4 0.1 2.5e-31 107.0 0.0 1.2 1 0 0 1 1 1 1 Cyanate lyase C-terminal domain HTH_31 PF13560.1 EWC46554.1 - 0.0052 16.9 0.0 0.0076 16.4 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_3 PF01381.17 EWC46554.1 - 0.12 12.1 0.0 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix 2OG-FeII_Oxy PF03171.15 EWC46555.1 - 4.1e-15 55.8 0.0 7.1e-15 55.1 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.1 EWC46555.1 - 2.9e-14 53.5 0.9 4.4e-14 53.0 0.1 1.6 2 0 0 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal PLDc_2 PF13091.1 EWC46556.1 - 2.4e-14 53.1 0.0 5.1e-05 23.0 0.0 3.5 3 0 0 3 3 3 3 PLD-like domain PLDc PF00614.17 EWC46556.1 - 2e-09 36.9 2.6 0.00033 20.3 0.2 2.9 3 0 0 3 3 3 2 Phospholipase D Active site motif DUF2927 PF11150.3 EWC46557.1 - 0.21 11.2 0.0 1.3 8.6 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2927) Zn_clus PF00172.13 EWC46558.1 - 1.1e-08 34.8 9.4 1.8e-08 34.1 6.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 EWC46558.1 - 1.6e-05 23.9 2.7 3.7e-05 22.7 1.9 1.7 1 0 0 1 1 1 1 Fungal specific transcription factor domain Glyco_hydro_3 PF00933.16 EWC46559.1 - 1e-78 264.3 0.0 1.8e-78 263.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.17 EWC46559.1 - 1e-66 224.7 0.0 3.3e-66 223.0 0.0 1.8 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.1 EWC46559.1 - 2.8e-27 94.4 1.9 7.3e-27 93.1 1.3 1.8 1 0 0 1 1 1 1 Fibronectin type III-like domain PA14 PF07691.7 EWC46559.1 - 1.8e-10 40.6 0.0 3.6e-10 39.6 0.0 1.5 1 0 0 1 1 1 1 PA14 domain CARDB PF07705.6 EWC46559.1 - 0.00051 20.0 0.5 0.0017 18.3 0.3 1.9 1 0 0 1 1 1 1 CARDB VWD PF00094.20 EWC46559.1 - 0.18 11.9 0.3 0.65 10.1 0.1 1.9 2 0 0 2 2 2 0 von Willebrand factor type D domain DUF11 PF01345.13 EWC46559.1 - 10 6.2 9.8 5.3 7.1 0.5 3.0 3 0 0 3 3 3 0 Domain of unknown function DUF11 Band_7 PF01145.20 EWC46561.1 - 3e-16 59.8 0.2 3e-16 59.8 0.1 3.0 2 1 1 3 3 3 1 SPFH domain / Band 7 family Glyco_hydro_3 PF00933.16 EWC46562.1 - 3.1e-80 269.3 0.0 4.5e-80 268.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.17 EWC46562.1 - 6.1e-61 205.8 0.0 1.5e-60 204.5 0.0 1.8 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.1 EWC46562.1 - 2.4e-18 65.8 0.2 6.3e-18 64.4 0.1 1.8 1 0 0 1 1 1 1 Fibronectin type III-like domain PA14 PF07691.7 EWC46562.1 - 7.1e-12 45.1 0.0 1.3e-11 44.3 0.0 1.4 1 0 0 1 1 1 1 PA14 domain CARDB PF07705.6 EWC46562.1 - 0.1 12.6 0.0 0.25 11.3 0.0 1.6 1 0 0 1 1 1 0 CARDB Zn_clus PF00172.13 EWC46563.1 - 4.6e-10 39.2 10.5 1.1e-09 38.0 7.3 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 EWC46563.1 - 0.004 16.0 0.5 0.021 13.7 0.4 2.0 1 1 0 1 1 1 1 Fungal specific transcription factor domain SLD3 PF08639.5 EWC46564.1 - 0.098 11.2 2.5 0.15 10.6 1.7 1.2 1 0 0 1 1 1 0 DNA replication regulator SLD3 Methyltransf_23 PF13489.1 EWC46565.1 - 0.00039 20.1 0.0 0.00065 19.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EWC46565.1 - 0.02 15.2 0.0 0.054 13.8 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.1 EWC46565.1 - 0.11 12.1 0.0 0.32 10.5 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain SNF2_N PF00176.18 EWC46566.1 - 3.3e-16 58.9 0.0 8.3e-13 47.7 0.0 2.5 2 0 0 2 2 2 2 SNF2 family N-terminal domain DNA_methylase PF00145.12 EWC46566.1 - 4.5e-15 55.6 0.0 9.6e-15 54.5 0.0 1.5 1 0 0 1 1 1 1 C-5 cytosine-specific DNA methylase ResIII PF04851.10 EWC46566.1 - 0.13 12.0 0.1 0.59 9.9 0.0 2.1 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit zf-C3HC4_2 PF13923.1 EWC46566.1 - 2.8 8.0 16.6 0.25 11.4 2.4 2.7 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) AAA_19 PF13245.1 EWC46567.1 - 0.28 10.9 1.3 1.5 8.6 0.3 2.4 2 0 0 2 2 2 0 Part of AAA domain Phage_holin_3 PF05106.7 EWC46567.1 - 1 9.3 8.1 0.26 11.2 0.4 2.4 2 0 0 2 2 2 0 Phage holin family (Lysis protein S) DUF946 PF06101.6 EWC46568.1 - 6.3e-12 44.2 2.6 7e-12 44.1 0.4 1.9 2 0 0 2 2 2 1 Plant protein of unknown function (DUF946) 2Fe-2S_thioredx PF01257.14 EWC46569.1 - 3.5e-59 198.5 0.0 4.3e-59 198.2 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin POM121 PF15229.1 EWC46569.1 - 0.12 11.7 3.1 4.1 6.7 0.1 2.1 2 0 0 2 2 2 0 POM121 family TFIIIC_sub6 PF10419.4 EWC46570.1 - 1.4e-12 46.8 0.1 2.2e-12 46.1 0.1 1.3 1 0 0 1 1 1 1 TFIIIC subunit CBM_5_12 PF02839.9 EWC46570.1 - 0.04 13.5 0.0 0.11 12.0 0.0 1.7 1 0 0 1 1 1 0 Carbohydrate binding domain DnaJ PF00226.26 EWC46571.1 - 2.3e-25 88.0 4.8 3.9e-25 87.3 3.3 1.4 1 0 0 1 1 1 1 DnaJ domain CTDII PF01556.13 EWC46571.1 - 5.6e-16 58.2 0.1 4.2e-15 55.4 0.0 2.4 2 1 0 2 2 2 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.14 EWC46571.1 - 7.7e-15 54.6 15.6 1.6e-14 53.6 10.8 1.6 1 0 0 1 1 1 1 DnaJ central domain HypA PF01155.14 EWC46571.1 - 0.034 13.8 0.5 0.034 13.8 0.3 2.3 2 0 0 2 2 2 0 Hydrogenase expression/synthesis hypA family PARP PF00644.15 EWC46572.1 - 4.8e-60 202.5 6.0 1.7e-59 200.7 0.0 3.2 3 1 1 4 4 4 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.9 EWC46572.1 - 1.5e-37 128.2 0.7 2.4e-37 127.5 0.5 1.4 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain WGR PF05406.10 EWC46572.1 - 3e-23 81.5 0.8 1.2e-22 79.6 0.6 2.1 1 0 0 1 1 1 1 WGR domain BRCT PF00533.21 EWC46572.1 - 7.8e-15 54.7 0.0 1.6e-14 53.7 0.0 1.6 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.2 EWC46572.1 - 4e-07 29.7 0.0 8.9e-07 28.6 0.0 1.7 1 0 0 1 1 1 1 twin BRCT domain CENP-N PF05238.8 EWC46572.1 - 0.075 12.0 8.2 0.13 11.2 5.7 1.4 1 0 0 1 1 1 0 Kinetochore protein CHL4 like Lactonase PF10282.4 EWC46573.1 - 4.9e-71 239.5 0.0 5.5e-71 239.4 0.0 1.0 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller Arylesterase PF01731.15 EWC46573.1 - 0.00033 20.5 0.1 0.24 11.4 0.0 3.1 3 0 0 3 3 3 2 Arylesterase DUF1223 PF06764.6 EWC46574.1 - 2.9e-50 170.9 0.0 3.8e-50 170.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1223) IlvC PF01450.14 EWC46575.1 - 1.8e-44 151.2 0.0 2.8e-44 150.5 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain IlvN PF07991.7 EWC46575.1 - 2.9e-27 95.0 0.0 5e-27 94.2 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain UQ_con PF00179.21 EWC46576.1 - 1.7e-38 131.2 0.0 2.1e-38 130.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 EWC46576.1 - 0.0024 17.6 0.0 0.0032 17.2 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.8 EWC46576.1 - 0.064 12.9 0.0 0.093 12.4 0.0 1.3 1 0 0 1 1 1 0 UEV domain ZZ PF00569.12 EWC46577.1 - 5.3e-17 61.0 58.9 1e-07 31.3 3.6 4.4 4 0 0 4 4 4 4 Zinc finger, ZZ type WH2 PF02205.15 EWC46577.1 - 0.012 15.2 0.0 0.027 14.0 0.0 1.6 1 0 0 1 1 1 0 WH2 motif DEAD PF00270.24 EWC46579.1 - 1.5e-31 109.2 0.0 2.4e-31 108.4 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EWC46579.1 - 6.8e-21 73.9 0.1 1.6e-20 72.7 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_19 PF13245.1 EWC46579.1 - 0.0011 18.6 0.6 0.38 10.5 0.1 2.8 2 1 0 2 2 2 2 Part of AAA domain FCH PF00611.18 EWC46580.1 - 5e-22 77.9 0.1 3e-21 75.3 0.0 2.5 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_1 PF00018.23 EWC46580.1 - 6.1e-18 63.9 0.6 2.5e-08 33.1 0.2 2.5 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.1 EWC46580.1 - 6.8e-18 63.9 0.5 6.4e-10 38.4 0.0 2.7 2 0 0 2 2 2 2 Variant SH3 domain C1_1 PF00130.17 EWC46580.1 - 3.9e-14 52.1 6.3 6.8e-14 51.3 4.4 1.4 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) SH3_2 PF07653.12 EWC46580.1 - 2.9e-05 23.4 0.1 0.18 11.3 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_3 PF08239.6 EWC46580.1 - 0.12 12.6 1.3 4.1 7.6 0.2 2.4 2 0 0 2 2 2 0 Bacterial SH3 domain DUF1154 PF06631.6 EWC46580.1 - 0.5 10.0 5.7 0.12 12.0 0.9 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1154) DUF641 PF04859.7 EWC46580.1 - 0.89 9.3 7.5 1.4 8.6 0.2 2.9 2 1 1 3 3 3 0 Plant protein of unknown function (DUF641) DUF342 PF03961.8 EWC46580.1 - 1.1 7.6 7.1 0.87 7.9 0.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF342) STAT_alpha PF01017.15 EWC46580.1 - 5.2 6.7 9.9 0.13 11.9 0.6 2.7 3 1 0 3 3 3 0 STAT protein, all-alpha domain IFRD PF05004.8 EWC46581.1 - 3.3e-36 124.9 0.0 4.2e-36 124.6 0.0 1.2 1 0 0 1 1 1 1 Interferon-related developmental regulator (IFRD) RAP1 PF07218.6 EWC46581.1 - 8.2 4.3 5.5 13 3.7 3.8 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DEAD PF00270.24 EWC46582.1 - 3.9e-45 153.3 0.0 7.7e-45 152.4 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF4217 PF13959.1 EWC46582.1 - 8e-22 76.5 0.1 1.8e-21 75.4 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) Helicase_C PF00271.26 EWC46582.1 - 2.4e-20 72.1 0.0 4.9e-20 71.1 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EWC46582.1 - 0.0058 16.4 0.4 0.023 14.5 0.0 2.2 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit Daxx PF03344.10 EWC46582.1 - 1.4 7.3 15.8 2 6.8 10.9 1.1 1 0 0 1 1 1 0 Daxx Family Med19 PF10278.4 EWC46582.1 - 1.9 8.1 9.4 3.6 7.2 6.5 1.4 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 TRP PF06011.7 EWC46583.1 - 2.4e-146 487.7 32.5 3.1e-146 487.3 22.5 1.1 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.1 EWC46583.1 - 4.2e-35 120.8 0.0 6.6e-35 120.2 0.0 1.3 1 0 0 1 1 1 1 ML-like domain DUF4389 PF14333.1 EWC46583.1 - 0.0017 18.0 0.1 0.0017 18.0 0.1 3.3 3 0 0 3 3 3 1 Domain of unknown function (DUF4389) gpUL132 PF11359.3 EWC46583.1 - 0.006 15.9 0.0 0.017 14.4 0.0 1.8 1 0 0 1 1 1 1 Glycoprotein UL132 FAD_binding_4 PF01565.18 EWC46584.1 - 1.5e-14 53.6 0.1 2.6e-14 52.8 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain RRM_6 PF14259.1 EWC46585.1 - 7.4e-10 38.6 0.0 2.7e-09 36.8 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 EWC46585.1 - 1.5e-09 37.2 0.1 3.1e-09 36.3 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EWC46585.1 - 8.8e-05 22.2 0.0 0.00022 21.0 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pro_isomerase PF00160.16 EWC46586.1 - 2.1e-43 148.2 0.2 3.4e-43 147.5 0.1 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Tbf5 PF06331.7 EWC46586.1 - 6.2e-13 48.3 1.7 1.4e-12 47.2 1.2 1.5 1 0 0 1 1 1 1 Transcription factor TFIIH complex subunit Tfb5 TPR_11 PF13414.1 EWC46586.1 - 4.1e-07 29.5 1.3 0.00034 20.1 0.3 2.3 1 1 1 2 2 2 2 TPR repeat TPR_1 PF00515.23 EWC46586.1 - 2.7e-05 23.5 1.9 3.2 7.5 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.12 EWC46586.1 - 0.00012 21.7 1.1 0.32 11.0 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat Tyr_Deacylase PF02580.11 EWC46587.1 - 2.2e-29 102.2 0.0 2.7e-29 102.0 0.0 1.1 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase Not3 PF04065.10 EWC46588.1 - 2.2e-100 334.7 24.8 3.3e-100 334.1 17.2 1.2 1 0 0 1 1 1 1 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.13 EWC46588.1 - 1.5e-43 147.9 10.2 1.5e-43 147.9 7.1 2.2 2 1 0 2 2 2 1 NOT2 / NOT3 / NOT5 family SNARE PF05739.14 EWC46588.1 - 0.0058 16.2 0.1 0.015 14.9 0.0 1.7 1 0 0 1 1 1 1 SNARE domain DUF2373 PF10180.4 EWC46588.1 - 0.0085 15.6 3.8 0.018 14.5 2.6 1.5 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2373) Cep57_MT_bd PF06657.8 EWC46588.1 - 0.0088 15.9 3.5 0.064 13.2 0.2 2.9 2 0 0 2 2 2 1 Centrosome microtubule-binding domain of Cep57 Transposase_22 PF02994.9 EWC46588.1 - 0.42 9.0 14.6 0.77 8.1 10.1 1.4 1 0 0 1 1 1 0 L1 transposable element Cob_adeno_trans PF01923.13 EWC46588.1 - 0.64 9.7 8.2 0.25 11.1 0.8 2.4 1 1 1 2 2 2 0 Cobalamin adenosyltransferase DUF1192 PF06698.6 EWC46588.1 - 0.73 9.6 7.4 0.67 9.8 0.6 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) Tubulin PF00091.20 EWC46590.1 - 3.8e-61 206.6 0.0 5.8e-61 206.0 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.12 EWC46590.1 - 3.7e-45 153.0 0.2 3.7e-45 153.0 0.1 1.7 2 0 0 2 2 2 1 Tubulin C-terminal domain HhH-GPD PF00730.20 EWC46591.1 - 2.1e-16 60.1 0.0 3.5e-16 59.4 0.0 1.4 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.18 EWC46591.1 - 0.00024 20.6 0.0 0.00067 19.2 0.0 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix motif Use1 PF09753.4 EWC46592.1 - 1.3e-05 24.7 2.4 2e-05 24.1 1.6 1.4 1 1 0 1 1 1 1 Membrane fusion protein Use1 YliH PF10799.3 EWC46592.1 - 0.014 15.0 0.4 0.036 13.7 0.2 1.6 1 0 0 1 1 1 0 Biofilm formation protein (YliH/bssR) DUF2360 PF10152.4 EWC46592.1 - 0.78 10.0 5.9 1.5 9.1 4.1 1.5 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) Synaptobrevin PF00957.16 EWC46592.1 - 1.3 8.6 7.6 2.1 8.0 0.4 3.0 3 1 0 3 3 3 0 Synaptobrevin Piwi PF02171.12 EWC46593.1 - 7.9e-72 241.7 0.0 3e-71 239.8 0.0 1.9 2 0 0 2 2 2 1 Piwi domain PAZ PF02170.17 EWC46593.1 - 4.7e-14 51.8 0.0 9.2e-14 50.9 0.0 1.5 1 0 0 1 1 1 1 PAZ domain DUF1785 PF08699.5 EWC46593.1 - 6.2e-10 38.2 0.1 1.7e-09 36.8 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1785) G-alpha PF00503.15 EWC46595.1 - 8.6e-131 436.2 4.9 1e-130 435.9 3.4 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.16 EWC46595.1 - 4.3e-15 55.3 2.5 1.8e-10 40.3 0.1 2.7 2 0 0 2 2 2 2 ADP-ribosylation factor family zf-CHC2 PF01807.15 EWC46595.1 - 2.9e-05 23.5 0.0 0.00013 21.4 0.0 1.9 2 0 0 2 2 2 1 CHC2 zinc finger Miro PF08477.8 EWC46595.1 - 0.0013 19.2 0.2 2 8.9 0.0 2.9 2 1 0 2 2 2 2 Miro-like protein Gtr1_RagA PF04670.7 EWC46595.1 - 0.0095 15.0 4.4 0.52 9.3 0.0 3.0 2 1 1 3 3 3 2 Gtr1/RagA G protein conserved region AAA_29 PF13555.1 EWC46595.1 - 0.016 14.7 0.0 0.036 13.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain GTP_EFTU PF00009.22 EWC46595.1 - 0.029 13.8 0.0 1.9 7.8 0.0 2.4 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain FtsK_SpoIIIE PF01580.13 EWC46595.1 - 0.063 12.7 0.0 0.15 11.5 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family MMR_HSR1 PF01926.18 EWC46595.1 - 0.11 12.5 0.0 13 5.7 0.0 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase Zip PF02535.17 EWC46596.1 - 7.1e-56 189.5 11.7 2.2e-55 187.8 8.1 1.7 1 1 0 1 1 1 1 ZIP Zinc transporter FixQ PF05545.6 EWC46596.1 - 0.64 9.7 5.9 2.7 7.6 0.1 3.3 3 0 0 3 3 3 0 Cbb3-type cytochrome oxidase component FixQ DLH PF01738.13 EWC46597.1 - 8.9e-26 90.5 0.0 1.2e-25 90.1 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_5 PF12695.2 EWC46597.1 - 2.4e-10 40.3 0.0 3.9e-10 39.6 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 EWC46597.1 - 0.00044 20.2 1.0 0.014 15.2 0.0 2.1 1 1 1 2 2 2 2 Alpha/beta hydrolase family BAAT_C PF08840.6 EWC46597.1 - 0.073 12.7 0.0 3 7.4 0.0 2.2 1 1 1 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal RasGEF PF00617.14 EWC46598.1 - 3.7e-21 75.6 0.7 3.7e-21 75.6 0.5 1.7 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.15 EWC46598.1 - 6.7e-07 29.3 0.1 1.8e-06 28.0 0.1 1.7 1 0 0 1 1 1 1 RasGEF N-terminal motif Rabaptin PF03528.10 EWC46598.1 - 0.092 12.6 1.5 0.42 10.5 1.0 2.1 1 0 0 1 1 1 0 Rabaptin DUF202 PF02656.10 EWC46600.1 - 3e-24 85.0 0.9 3e-24 85.0 0.6 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF202) DUF1771 PF08590.5 EWC46601.1 - 1.7e-19 69.5 11.0 3.5e-19 68.5 7.6 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1771) Smr PF01713.16 EWC46601.1 - 3.2e-15 56.0 0.1 3.2e-15 56.0 0.1 2.2 2 0 0 2 2 2 1 Smr domain V_ATPase_I PF01496.14 EWC46601.1 - 0.056 11.3 0.5 0.075 10.8 0.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ProQ PF04352.8 EWC46601.1 - 0.15 11.7 8.7 5 6.7 0.0 2.8 2 1 1 3 3 3 0 ProQ/FINO family KTI12 PF08433.5 EWC46602.1 - 5.3e-92 307.8 0.0 5.9e-92 307.6 0.0 1.0 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_33 PF13671.1 EWC46602.1 - 4.3e-06 26.6 0.0 1.1e-05 25.3 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 EWC46602.1 - 0.015 16.1 0.0 0.028 15.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain CPT PF07931.7 EWC46602.1 - 0.017 14.7 0.0 0.029 14.0 0.0 1.3 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein Glyco_hydro_18 PF00704.23 EWC46603.1 - 1e-19 71.2 0.0 2.7e-19 69.8 0.0 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 RhoGAP PF00620.22 EWC46605.1 - 8.4e-32 109.8 0.0 1.9e-31 108.7 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain zf-Tim10_DDP PF02953.10 EWC46606.1 - 4.6e-20 70.6 3.3 5.4e-20 70.4 2.3 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger DUF842 PF05811.8 EWC46606.1 - 0.0013 18.1 2.4 0.0016 17.9 1.6 1.2 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF842) DUF2521 PF10730.4 EWC46606.1 - 0.018 14.8 0.2 0.021 14.6 0.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2521) Ku_PK_bind PF08785.6 EWC46606.1 - 0.065 13.1 0.2 0.081 12.8 0.1 1.2 1 0 0 1 1 1 0 Ku C terminal domain like Aminotran_5 PF00266.14 EWC46607.1 - 1.2e-98 330.2 0.0 1.5e-98 329.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.16 EWC46607.1 - 5.1e-09 35.6 0.0 7.6e-09 35.1 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.12 EWC46607.1 - 6.3e-05 22.1 0.1 0.00037 19.6 0.0 2.2 3 0 0 3 3 3 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.15 EWC46607.1 - 0.0093 14.2 0.0 0.014 13.7 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Pyridoxal_deC PF00282.14 EWC46607.1 - 0.012 14.0 0.0 0.017 13.5 0.0 1.2 1 0 0 1 1 1 0 Pyridoxal-dependent decarboxylase conserved domain BAR PF03114.13 EWC46608.1 - 4.6e-63 212.8 7.6 7.5e-63 212.1 5.3 1.3 1 0 0 1 1 1 1 BAR domain SH3_9 PF14604.1 EWC46608.1 - 4.7e-14 51.6 0.0 7.7e-14 51.0 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 EWC46608.1 - 1.1e-13 50.2 0.0 2e-13 49.4 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.12 EWC46608.1 - 2e-08 33.6 0.0 5.3e-08 32.2 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain Vps5 PF09325.5 EWC46608.1 - 0.00012 21.4 8.6 0.025 13.8 3.5 2.4 2 0 0 2 2 2 2 Vps5 C terminal like DUF1007 PF06226.8 EWC46608.1 - 0.054 13.2 0.8 0.12 12.1 0.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1007) BRE1 PF08647.6 EWC46608.1 - 0.11 12.5 0.1 0.11 12.5 0.1 3.3 3 1 0 3 3 3 0 BRE1 E3 ubiquitin ligase Laminin_II PF06009.7 EWC46608.1 - 0.14 11.9 4.3 0.93 9.2 1.7 2.4 2 0 0 2 2 2 0 Laminin Domain II APG6 PF04111.7 EWC46608.1 - 0.36 9.8 10.5 3.7 6.5 4.1 2.4 2 0 0 2 2 2 0 Autophagy protein Apg6 DUF3391 PF11871.3 EWC46608.1 - 2.5 8.3 6.5 2.7 8.2 1.5 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF3391) CorA PF01544.13 EWC46608.1 - 4 6.3 12.3 5.8 5.8 0.0 2.7 3 0 0 3 3 3 0 CorA-like Mg2+ transporter protein UEV PF05743.8 EWC46609.1 - 1e-37 128.5 0.0 1.8e-37 127.7 0.0 1.4 1 0 0 1 1 1 1 UEV domain Vps23_core PF09454.5 EWC46609.1 - 3.1e-27 93.9 0.4 6.5e-27 92.9 0.3 1.6 1 0 0 1 1 1 1 Vps23 core domain DUF1661 PF07877.6 EWC46609.1 - 0.013 15.0 0.2 0.027 13.9 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1661) GSHPx PF00255.14 EWC46610.1 - 4.6e-41 138.5 0.0 5.7e-41 138.2 0.0 1.1 1 0 0 1 1 1 1 Glutathione peroxidase Redoxin PF08534.5 EWC46610.1 - 6.9e-05 22.4 0.0 0.00012 21.6 0.0 1.4 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.16 EWC46610.1 - 0.00045 19.9 0.0 0.0007 19.2 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family DUF4174 PF13778.1 EWC46610.1 - 0.025 14.6 0.0 0.049 13.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4174) DUF3905 PF13045.1 EWC46610.1 - 0.028 14.1 0.0 0.089 12.5 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3905) Tom37_C PF11801.3 EWC46612.1 - 0.0017 18.2 0.0 0.012 15.4 0.0 1.9 1 1 1 2 2 2 1 Tom37 C-terminal domain Methyltransf_18 PF12847.2 EWC46613.1 - 4.1e-12 46.6 0.0 5.9e-12 46.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EWC46613.1 - 7.6e-11 41.8 0.0 1e-10 41.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EWC46613.1 - 1.1e-08 35.4 0.1 2.7e-08 34.1 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EWC46613.1 - 2.6e-08 34.1 0.0 4e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EWC46613.1 - 1.1e-07 31.3 0.0 1.9e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_23 PF13489.1 EWC46613.1 - 2.3e-06 27.4 0.0 3.8e-06 26.6 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 EWC46613.1 - 3.3e-06 26.3 0.0 4.4e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_12 PF08242.7 EWC46613.1 - 4e-06 27.2 0.1 1.1e-05 25.8 0.1 1.8 1 1 0 1 1 1 1 Methyltransferase domain TehB PF03848.9 EWC46613.1 - 4.6e-06 25.9 0.0 7.9e-06 25.1 0.0 1.3 1 0 0 1 1 1 1 Tellurite resistance protein TehB RrnaAD PF00398.15 EWC46613.1 - 4.5e-05 22.6 0.0 5.6e-05 22.3 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Ubie_methyltran PF01209.13 EWC46613.1 - 6.9e-05 22.0 0.0 0.00012 21.3 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family FmrO PF07091.6 EWC46613.1 - 0.0029 16.6 0.0 0.0039 16.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA methyltransferase (FmrO) Methyltransf_26 PF13659.1 EWC46613.1 - 0.0067 16.4 0.1 0.011 15.7 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 EWC46613.1 - 0.0095 15.4 0.0 0.014 14.9 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_32 PF13679.1 EWC46613.1 - 0.029 14.0 0.0 0.044 13.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_15 PF09445.5 EWC46613.1 - 0.058 12.9 0.0 0.077 12.5 0.0 1.2 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase GidB PF02527.10 EWC46613.1 - 0.069 12.2 0.0 0.089 11.9 0.0 1.1 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G Methyltransf_7 PF03492.10 EWC46613.1 - 0.09 11.5 0.0 0.13 10.9 0.0 1.3 1 0 0 1 1 1 0 SAM dependent carboxyl methyltransferase CDC14 PF08045.6 EWC46614.1 - 1.2e-52 178.6 0.0 1.4e-52 178.3 0.0 1.0 1 0 0 1 1 1 1 Cell division control protein 14, SIN component polyprenyl_synt PF00348.12 EWC46615.1 - 4.5e-55 186.3 0.0 6e-55 185.8 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase Terpene_synth_C PF03936.11 EWC46615.1 - 0.016 14.4 0.0 0.028 13.6 0.0 1.3 1 0 0 1 1 1 0 Terpene synthase family, metal binding domain HAD PF12710.2 EWC46616.1 - 2.7e-10 40.7 0.0 4.5e-10 40.0 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.7 EWC46616.1 - 0.0018 17.5 0.0 0.0083 15.3 0.0 1.9 1 1 0 1 1 1 1 Putative Phosphatase Hydrolase PF00702.21 EWC46616.1 - 0.0044 17.4 0.2 0.071 13.5 0.1 2.3 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase UMPH-1 PF05822.7 EWC46616.1 - 0.067 12.5 0.1 0.12 11.6 0.1 1.5 1 1 0 1 1 1 0 Pyrimidine 5'-nucleotidase (UMPH-1) PS_Dcarbxylase PF02666.10 EWC46617.1 - 4.8e-52 176.2 0.0 7e-52 175.6 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase C2 PF00168.25 EWC46617.1 - 1.8e-38 130.2 1.0 2.8e-19 68.7 0.0 2.5 2 0 0 2 2 2 2 C2 domain CEP76-C2 PF15627.1 EWC46617.1 - 0.0013 18.2 0.0 0.02 14.4 0.0 2.3 2 0 0 2 2 2 1 CEP76 C2 domain EF-hand_1 PF00036.27 EWC46617.1 - 0.021 14.0 0.4 0.056 12.7 0.0 2.0 2 0 0 2 2 2 0 EF hand EF-hand_7 PF13499.1 EWC46617.1 - 0.051 13.7 0.0 0.15 12.2 0.0 1.8 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.1 EWC46617.1 - 0.078 12.8 0.0 0.28 11.1 0.0 2.0 1 0 0 1 1 1 0 EF-hand domain MIS13 PF08202.6 EWC46618.1 - 7.2e-43 146.7 5.3 7.2e-43 146.7 3.7 2.1 3 0 0 3 3 3 1 Mis12-Mtw1 protein family CAP_N PF01213.14 EWC46618.1 - 0.052 12.8 3.5 0.11 11.7 2.4 1.5 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg PF05308.6 EWC46618.1 - 0.054 12.8 13.9 0.042 13.2 2.4 3.0 3 0 0 3 3 3 0 Mitochondrial fission regulator GATA PF00320.22 EWC46619.1 - 1e-14 53.5 5.2 2e-14 52.6 3.6 1.5 1 0 0 1 1 1 1 GATA zinc finger zf-RING_3 PF14369.1 EWC46619.1 - 0.28 11.2 1.9 0.61 10.1 1.3 1.5 1 0 0 1 1 1 0 zinc-finger GCS PF03074.11 EWC46620.1 - 1.6e-158 527.6 0.0 2.1e-158 527.2 0.0 1.2 1 0 0 1 1 1 1 Glutamate-cysteine ligase GCS2 PF04107.8 EWC46620.1 - 0.00082 18.5 0.0 0.0063 15.6 0.0 2.0 2 0 0 2 2 2 1 Glutamate-cysteine ligase family 2(GCS2) Ank_2 PF12796.2 EWC46621.1 - 2.2e-16 59.9 1.0 6.9e-10 39.1 0.0 3.6 3 1 0 4 4 4 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 EWC46621.1 - 7.4e-15 54.6 0.1 1.2e-08 34.9 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.25 EWC46621.1 - 9.1e-15 53.6 0.4 1.6e-07 30.7 0.0 3.8 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.1 EWC46621.1 - 2.1e-14 53.5 0.1 9.4e-11 41.9 0.0 3.3 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 EWC46621.1 - 2.2e-10 39.7 2.8 4.9e-05 23.1 0.0 5.2 6 0 0 6 6 6 2 Ankyrin repeat KilA-N PF04383.8 EWC46621.1 - 3.4e-05 23.4 0.0 0.00018 21.1 0.0 2.1 1 1 0 1 1 1 1 KilA-N domain GDPD PF03009.12 EWC46622.1 - 3.3e-30 105.4 0.0 4.5e-30 105.0 0.0 1.2 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family GDPD_2 PF13653.1 EWC46622.1 - 3.3e-06 27.1 0.2 6.5e-06 26.1 0.1 1.5 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family DUF3302 PF11742.3 EWC46622.1 - 0.02 14.7 0.9 0.04 13.7 0.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3302) Colicin_V PF02674.11 EWC46622.1 - 0.094 12.5 0.1 0.16 11.8 0.1 1.3 1 0 0 1 1 1 0 Colicin V production protein Translin PF01997.11 EWC46623.1 - 3.1e-47 160.7 0.0 3.6e-47 160.5 0.0 1.0 1 0 0 1 1 1 1 Translin family GMP_synt_C PF00958.17 EWC46623.1 - 0.13 11.9 0.0 0.38 10.5 0.0 1.7 1 0 0 1 1 1 0 GMP synthase C terminal domain UvsW PF11637.3 EWC46623.1 - 0.15 11.7 1.1 0.34 10.6 0.8 1.5 1 0 0 1 1 1 0 ATP-dependant DNA helicase UvsW Seryl_tRNA_N PF02403.17 EWC46623.1 - 0.33 10.9 1.7 0.48 10.4 0.4 1.8 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain PIG-F PF06699.6 EWC46624.1 - 3.5e-52 177.1 2.0 4.2e-52 176.8 1.4 1.0 1 0 0 1 1 1 1 GPI biosynthesis protein family Pig-F PRA1 PF03208.14 EWC46624.1 - 0.26 10.5 1.8 0.41 9.9 1.2 1.4 1 1 0 1 1 1 0 PRA1 family protein Bacteriocin_IIc PF10439.4 EWC46624.1 - 1.9 8.6 8.9 1.4 9.1 0.1 3.2 3 0 0 3 3 3 0 Bacteriocin class II with double-glycine leader peptide COPIIcoated_ERV PF07970.7 EWC46625.1 - 1.4e-38 132.7 0.0 2e-38 132.2 0.0 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.1 EWC46625.1 - 4.9e-24 84.1 0.0 8.1e-24 83.4 0.0 1.3 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) FlgD_ig PF13860.1 EWC46625.1 - 0.093 12.4 0.0 0.19 11.4 0.0 1.5 1 0 0 1 1 1 0 FlgD Ig-like domain ubiquitin PF00240.18 EWC46626.1 - 6.8e-35 118.2 0.7 1.2e-34 117.5 0.5 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 EWC46626.1 - 9.3e-20 70.0 0.7 1.3e-19 69.6 0.5 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like zf-AN1 PF01428.11 EWC46626.1 - 9.2e-10 38.2 12.0 1.4e-09 37.7 8.3 1.2 1 0 0 1 1 1 1 AN1-like Zinc finger Ubiquitin_2 PF14560.1 EWC46626.1 - 1.2e-05 25.4 0.1 4.2e-05 23.7 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain Telomere_Sde2 PF13019.1 EWC46626.1 - 0.00017 21.3 0.0 0.00027 20.6 0.0 1.3 1 0 0 1 1 1 1 Telomere stability and silencing Rad60-SLD_2 PF13881.1 EWC46626.1 - 0.01 15.7 0.0 0.03 14.1 0.0 1.8 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.4 EWC46626.1 - 0.016 15.3 0.0 0.018 15.2 0.0 1.3 1 1 0 1 1 1 0 DUF2407 ubiquitin-like domain DUF2870 PF11069.3 EWC46626.1 - 0.031 14.3 0.1 0.14 12.2 0.0 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF2870) CsbD PF05532.7 EWC46627.1 - 8.3e-10 38.1 13.4 2e-08 33.7 1.2 3.2 3 0 0 3 3 3 2 CsbD-like STE2 PF02116.10 EWC46628.1 - 3.3e-51 174.0 10.2 4e-51 173.7 7.0 1.1 1 0 0 1 1 1 1 Fungal pheromone mating factor STE2 GPCR DUF1325 PF07039.6 EWC46629.1 - 9.6e-27 93.1 0.0 6.1e-26 90.5 0.0 2.1 1 1 0 1 1 1 1 SGF29 tudor-like domain Myb_DNA-bind_4 PF13837.1 EWC46629.1 - 0.053 13.6 0.3 0.11 12.6 0.2 1.6 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain DUF603 PF04645.7 EWC46629.1 - 0.074 12.9 0.1 0.11 12.3 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF603 FlgN PF05130.7 EWC46629.1 - 0.64 10.2 5.5 3.8 7.7 3.8 2.0 1 1 0 1 1 1 0 FlgN protein Actin PF00022.14 EWC46630.1 - 1.1e-113 379.6 0.0 1.3e-113 379.4 0.0 1.0 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.8 EWC46630.1 - 0.033 12.7 0.0 0.24 9.9 0.0 2.2 1 1 0 1 1 1 0 MreB/Mbl protein GTP_cyclohydro2 PF00925.15 EWC46631.1 - 7.9e-61 204.1 0.0 2.1e-55 186.5 0.0 2.1 2 0 0 2 2 2 2 GTP cyclohydrolase II Clathrin PF00637.15 EWC46632.1 - 1.5e-16 60.3 3.5 1.7e-15 56.9 0.3 2.9 3 0 0 3 3 3 1 Region in Clathrin and VPS VPS11_C PF12451.3 EWC46632.1 - 6.3e-09 35.5 0.3 1.7e-08 34.1 0.2 1.8 1 0 0 1 1 1 1 Vacuolar protein sorting protein 11 C terminal zf-RING_2 PF13639.1 EWC46632.1 - 0.00025 20.8 8.0 0.00046 19.9 5.6 1.5 1 0 0 1 1 1 1 Ring finger domain Vps8 PF12816.2 EWC46632.1 - 0.00088 18.5 0.3 0.0022 17.3 0.2 1.6 1 0 0 1 1 1 1 Golgi CORVET complex core vacuolar protein 8 zf-RING_5 PF14634.1 EWC46632.1 - 0.003 17.2 6.3 0.0053 16.4 4.4 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 EWC46632.1 - 0.006 16.5 7.5 0.011 15.7 5.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 EWC46632.1 - 0.023 14.7 2.8 0.047 13.8 2.0 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger zf-C3HC4 PF00097.20 EWC46632.1 - 0.043 13.4 7.8 0.078 12.6 5.4 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) TPR_12 PF13424.1 EWC46632.1 - 0.048 13.5 0.2 0.29 11.1 0.0 2.4 2 0 0 2 2 1 0 Tetratricopeptide repeat TPR_11 PF13414.1 EWC46632.1 - 0.057 13.0 0.0 0.19 11.3 0.0 1.8 1 0 0 1 1 1 0 TPR repeat TPR_8 PF13181.1 EWC46632.1 - 0.061 13.1 0.2 0.38 10.6 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat RPN7 PF10602.4 EWC46632.1 - 0.076 12.3 0.1 0.23 10.8 0.1 1.7 1 0 0 1 1 1 0 26S proteasome subunit RPN7 zf-RING_6 PF14835.1 EWC46632.1 - 0.18 11.6 1.0 0.38 10.5 0.7 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-Nse PF11789.3 EWC46632.1 - 1.7 8.1 5.4 4.1 7.0 3.7 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit PHD PF00628.24 EWC46632.1 - 2.4 7.9 5.0 4.7 6.9 3.5 1.5 1 0 0 1 1 1 0 PHD-finger Pkinase PF00069.20 EWC46633.1 - 6.1e-63 212.3 0.0 1.4e-62 211.1 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC46633.1 - 3.9e-36 124.4 0.0 6.5e-36 123.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase HR1 PF02185.11 EWC46633.1 - 6.7e-29 99.4 19.0 1.2e-17 63.4 4.4 2.4 2 0 0 2 2 2 2 Hr1 repeat C1_1 PF00130.17 EWC46633.1 - 1.1e-21 76.3 29.5 4.4e-12 45.5 7.0 2.4 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_C PF00433.19 EWC46633.1 - 1.7e-14 54.0 3.1 1.7e-14 54.0 2.2 2.4 2 0 0 2 2 2 1 Protein kinase C terminal domain Kinase-like PF14531.1 EWC46633.1 - 0.0046 15.9 0.0 0.0084 15.0 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Uds1 PF15456.1 EWC46633.1 - 0.19 11.6 7.8 0.11 12.4 0.4 2.4 2 0 0 2 2 2 0 Up-regulated During Septation DUF892 PF05974.7 EWC46633.1 - 2 8.2 5.8 0.18 11.6 0.5 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF892) FYVE_2 PF02318.11 EWC46633.1 - 5.5 6.9 19.8 6.9 6.5 4.2 2.7 1 1 1 2 2 2 0 FYVE-type zinc finger IDO PF01231.13 EWC46634.1 - 2.4e-160 533.6 0.0 2.9e-160 533.3 0.0 1.0 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase DUF1864 PF08933.6 EWC46634.1 - 0.16 10.4 0.0 1.3 7.4 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1864) Pkinase PF00069.20 EWC46635.1 - 7.7e-57 192.3 0.0 1.5e-56 191.4 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC46635.1 - 1.1e-19 70.5 0.0 3.2e-19 69.0 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.18 EWC46635.1 - 0.00057 19.6 0.0 0.0031 17.2 0.0 1.9 1 1 0 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 EWC46635.1 - 0.11 11.9 0.1 0.23 10.9 0.0 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase FTA4 PF13093.1 EWC46636.1 - 1.8e-40 138.6 0.0 2.1e-40 138.4 0.0 1.1 1 0 0 1 1 1 1 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 MCM PF00493.18 EWC46637.1 - 9.4e-139 461.8 0.0 1.6e-138 461.0 0.0 1.4 1 0 0 1 1 1 1 MCM2/3/5 family MCM2_N PF12619.3 EWC46637.1 - 2.5e-23 82.8 33.0 2.5e-23 82.8 22.9 1.8 2 0 0 2 2 2 1 Mini-chromosome maintenance protein 2 MCM_N PF14551.1 EWC46637.1 - 9.5e-19 68.0 0.1 2e-18 67.0 0.0 1.6 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.16 EWC46637.1 - 1.5e-08 34.0 0.0 1.4e-06 27.6 0.0 2.4 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 EWC46637.1 - 1.1e-06 28.4 0.0 2.4e-06 27.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.6 EWC46637.1 - 0.00026 20.6 0.0 0.002 17.7 0.0 2.3 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 EWC46637.1 - 0.0021 17.5 0.0 0.011 15.2 0.0 1.9 1 1 0 1 1 1 1 Sigma-54 interaction domain DUF3626 PF12294.3 EWC46637.1 - 0.14 11.1 0.1 0.5 9.3 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3626) DUF869 PF05911.6 EWC46638.1 - 0.00041 18.7 25.6 0.0054 15.0 17.7 2.8 1 1 0 1 1 1 1 Plant protein of unknown function (DUF869) DUF4201 PF13870.1 EWC46638.1 - 0.002 17.5 10.2 0.002 17.5 7.1 4.0 3 1 1 4 4 4 1 Domain of unknown function (DUF4201) GAS PF13851.1 EWC46638.1 - 0.0036 16.5 29.1 0.0074 15.4 4.2 4.6 2 1 1 3 3 3 2 Growth-arrest specific micro-tubule binding IncA PF04156.9 EWC46638.1 - 0.017 14.7 38.0 0.046 13.3 3.9 3.3 1 1 1 2 2 2 0 IncA protein DUF2400 PF09674.5 EWC46638.1 - 0.061 13.0 0.8 0.16 11.6 0.1 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF2400) Reo_sigmaC PF04582.7 EWC46638.1 - 0.11 11.5 16.5 0.065 12.3 4.2 2.9 1 1 2 3 3 3 0 Reovirus sigma C capsid protein Filament PF00038.16 EWC46638.1 - 0.4 10.1 29.9 0.096 12.1 5.0 3.5 1 1 1 2 2 2 0 Intermediate filament protein Myosin_tail_1 PF01576.14 EWC46638.1 - 0.92 7.1 41.9 0.1 10.2 7.4 2.7 2 1 1 3 3 3 0 Myosin tail MAD PF05557.8 EWC46638.1 - 1.3 7.0 30.8 0.24 9.4 2.9 3.6 1 1 2 3 3 3 0 Mitotic checkpoint protein Syntaxin PF00804.20 EWC46638.1 - 1.4 9.0 14.3 3.5 7.8 1.4 2.8 2 1 0 2 2 2 0 Syntaxin ADIP PF11559.3 EWC46638.1 - 2.5 8.0 29.8 0.038 13.8 2.7 3.9 1 1 4 5 5 5 0 Afadin- and alpha -actinin-Binding Spc7 PF08317.6 EWC46638.1 - 2.9 6.4 25.1 0.33 9.5 7.2 2.9 1 1 2 3 3 3 0 Spc7 kinetochore protein Syntaxin-6_N PF09177.6 EWC46638.1 - 3.5 8.1 18.9 0.49 10.8 0.5 4.2 2 1 3 5 5 5 0 Syntaxin 6, N-terminal AAA_13 PF13166.1 EWC46638.1 - 3.7 5.9 25.5 0.012 14.1 10.3 2.1 2 1 1 3 3 3 0 AAA domain CENP-F_leu_zip PF10473.4 EWC46638.1 - 6.1 6.7 39.3 0.12 12.2 7.3 3.8 2 1 2 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Microtub_assoc PF07989.6 EWC46638.1 - 7.1 6.5 13.5 2.7 7.9 0.1 4.6 2 1 2 5 5 5 0 Microtubule associated ATG16 PF08614.6 EWC46638.1 - 8.8 6.1 38.5 2.8 7.7 7.2 4.4 2 1 3 5 5 5 0 Autophagy protein 16 (ATG16) Kinesin PF00225.18 EWC46639.1 - 3.8e-89 298.6 0.2 1.5e-88 296.7 0.0 2.2 2 0 0 2 2 2 1 Kinesin motor domain Filament PF00038.16 EWC46639.1 - 5.9e-05 22.6 23.1 0.00041 19.9 4.5 8.1 5 3 1 7 7 7 4 Intermediate filament protein IncA PF04156.9 EWC46639.1 - 0.00088 18.9 8.7 0.00088 18.9 6.0 9.5 7 2 2 10 10 10 5 IncA protein CENP-F_leu_zip PF10473.4 EWC46639.1 - 2.2 8.1 103.7 0.02 14.7 11.5 7.7 4 2 3 7 7 7 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Linker_histone PF00538.14 EWC46640.1 - 5.2e-27 93.7 0.1 9.7e-27 92.8 0.1 1.5 1 0 0 1 1 1 1 linker histone H1 and H5 family DUF3123 PF11321.3 EWC46640.1 - 0.097 12.9 4.4 0.15 12.3 3.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3123) DUF1212 PF06738.7 EWC46641.1 - 2.2e-49 167.5 11.6 4.7e-47 159.9 0.2 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF1212) DUF3815 PF12821.2 EWC46641.1 - 1.5e-26 92.8 9.6 1.5e-26 92.8 6.7 2.9 3 0 0 3 3 3 1 Protein of unknown function (DUF3815) DUF837 PF05769.6 EWC46643.1 - 5.8e-05 22.7 7.6 8.7e-05 22.1 5.2 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF837) DUF3972 PF13118.1 EWC46643.1 - 0.07 13.2 1.9 6.9 6.7 0.1 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF3972) Cob_adeno_trans PF01923.13 EWC46643.1 - 0.21 11.3 4.4 0.2 11.4 0.5 2.2 1 1 1 2 2 2 0 Cobalamin adenosyltransferase HALZ PF02183.13 EWC46643.1 - 1.4 8.7 9.9 0.5 10.1 0.3 3.6 4 0 0 4 4 4 0 Homeobox associated leucine zipper DUF904 PF06005.7 EWC46643.1 - 2.3 8.5 11.0 2.7 8.3 0.9 3.7 3 1 1 4 4 4 0 Protein of unknown function (DUF904) DUF4407 PF14362.1 EWC46643.1 - 6.6 5.6 8.9 2.1 7.1 0.9 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) bZIP_2 PF07716.10 EWC46643.1 - 9.8 6.0 11.3 2.3 8.1 0.2 3.3 4 0 0 4 4 4 0 Basic region leucine zipper AT_hook PF02178.14 EWC46644.1 - 0.00026 20.3 24.5 0.27 11.0 3.4 4.9 3 0 0 3 3 3 3 AT hook motif SAC3_GANP PF03399.11 EWC46645.1 - 2.6e-27 95.7 0.0 3.7e-27 95.2 0.0 1.1 1 0 0 1 1 1 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family PCI_Csn8 PF10075.4 EWC46645.1 - 2.8e-21 75.7 0.0 4.4e-21 75.1 0.0 1.3 1 0 0 1 1 1 1 COP9 signalosome, subunit CSN8 Kelch_6 PF13964.1 EWC46646.1 - 0.00088 19.3 0.0 0.18 12.0 0.0 3.4 3 0 0 3 3 3 1 Kelch motif WD40 PF00400.27 EWC46646.1 - 0.011 15.6 8.9 0.9 9.5 0.0 4.6 5 0 0 5 5 5 0 WD domain, G-beta repeat Fungal_trans_2 PF11951.3 EWC46647.1 - 2.6e-57 194.1 0.0 3.4e-57 193.7 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EWC46647.1 - 2.1e-09 37.1 9.7 3.4e-09 36.4 6.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Cu_amine_oxid PF01179.15 EWC46648.1 - 3.1e-157 523.5 0.0 3.8e-157 523.2 0.0 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN2 PF02727.11 EWC46648.1 - 1.6e-12 47.2 0.2 3.4e-12 46.2 0.1 1.6 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain Cu_amine_oxidN3 PF02728.11 EWC46648.1 - 1.6e-06 28.1 0.0 4.1e-06 26.7 0.0 1.6 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain ABC_tran PF00005.22 EWC46649.1 - 1.2e-48 164.8 0.9 8e-26 90.9 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC2_membrane PF01061.19 EWC46649.1 - 4.1e-42 143.7 34.3 5e-24 84.6 10.9 2.3 2 0 0 2 2 2 2 ABC-2 type transporter AAA_21 PF13304.1 EWC46649.1 - 5e-18 66.0 3.4 0.00032 20.7 0.0 4.4 3 1 0 4 4 4 4 AAA domain SMC_N PF02463.14 EWC46649.1 - 2.2e-12 46.7 0.5 7.6e-05 22.0 0.0 3.9 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 EWC46649.1 - 1.2e-09 37.4 3.7 0.00039 19.8 0.7 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_15 PF13175.1 EWC46649.1 - 5.4e-09 35.6 0.0 0.043 12.8 0.0 4.1 4 0 0 4 4 4 2 AAA ATPase domain DUF258 PF03193.11 EWC46649.1 - 1.2e-08 34.3 2.7 0.00036 19.7 0.1 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_23 PF13476.1 EWC46649.1 - 1.9e-08 34.9 0.3 0.0029 17.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.1 EWC46649.1 - 4.2e-08 33.4 4.1 0.0041 17.1 0.0 3.4 2 1 1 3 3 3 2 AAA ATPase domain AAA_25 PF13481.1 EWC46649.1 - 1.2e-06 28.0 0.3 0.053 12.9 0.1 3.3 3 0 0 3 3 3 2 AAA domain AAA_22 PF13401.1 EWC46649.1 - 8.8e-06 25.8 0.6 0.046 13.8 0.0 3.1 3 0 0 3 3 2 2 AAA domain AAA_17 PF13207.1 EWC46649.1 - 1e-05 26.3 0.0 0.22 12.3 0.0 2.7 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.17 EWC46649.1 - 3.2e-05 24.0 0.2 0.11 12.7 0.0 2.6 2 0 0 2 2 2 2 RNA helicase Arch_ATPase PF01637.13 EWC46649.1 - 4e-05 23.4 0.0 0.032 13.9 0.0 2.5 2 0 0 2 2 2 1 Archaeal ATPase AAA_33 PF13671.1 EWC46649.1 - 6.4e-05 22.8 0.1 0.032 14.1 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.9 EWC46649.1 - 6.8e-05 22.6 0.6 0.67 9.6 0.1 3.2 3 0 0 3 3 3 2 AAA domain (dynein-related subfamily) SbcCD_C PF13558.1 EWC46649.1 - 7.3e-05 22.6 0.5 0.45 10.4 0.0 3.6 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_18 PF13238.1 EWC46649.1 - 9.8e-05 22.6 0.1 0.2 11.9 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.1 EWC46649.1 - 0.00011 21.8 0.1 0.18 11.3 0.1 2.5 2 0 0 2 2 2 2 AAA domain NACHT PF05729.7 EWC46649.1 - 0.00012 21.7 0.2 0.18 11.4 0.0 2.6 2 0 0 2 2 2 2 NACHT domain ATP_bind_1 PF03029.12 EWC46649.1 - 0.00017 21.2 0.5 2 7.9 0.0 3.4 3 0 0 3 3 3 1 Conserved hypothetical ATP binding protein MMR_HSR1 PF01926.18 EWC46649.1 - 0.00026 20.9 2.1 0.63 10.0 0.1 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_28 PF13521.1 EWC46649.1 - 0.00027 20.9 0.6 1.1 9.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA PF00004.24 EWC46649.1 - 0.00072 19.7 0.1 1.9 8.6 0.1 3.3 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) KAP_NTPase PF07693.9 EWC46649.1 - 0.00082 18.4 0.0 0.89 8.4 0.0 2.3 2 0 0 2 2 2 2 KAP family P-loop domain Miro PF08477.8 EWC46649.1 - 0.0013 19.1 0.2 1.1 9.8 0.0 2.7 2 0 0 2 2 2 1 Miro-like protein Zeta_toxin PF06414.7 EWC46649.1 - 0.0024 16.9 1.5 0.92 8.5 0.2 2.3 2 0 0 2 2 2 2 Zeta toxin AAA_10 PF12846.2 EWC46649.1 - 0.003 17.0 5.7 0.088 12.2 0.1 2.5 2 0 0 2 2 2 1 AAA-like domain FtsK_SpoIIIE PF01580.13 EWC46649.1 - 0.0046 16.4 1.4 1.7 8.0 0.1 2.4 2 0 0 2 2 2 1 FtsK/SpoIIIE family MobB PF03205.9 EWC46649.1 - 0.0061 16.2 0.2 1.2 8.8 0.0 2.5 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B cobW PF02492.14 EWC46649.1 - 0.007 15.8 3.2 1.1 8.6 0.1 2.3 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain T2SE PF00437.15 EWC46649.1 - 0.0091 14.9 2.0 1.2 8.0 0.0 2.7 3 0 0 3 3 3 1 Type II/IV secretion system protein UPF0079 PF02367.12 EWC46649.1 - 0.01 15.4 0.7 3.1 7.4 0.1 2.5 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 ATP-synt_ab PF00006.20 EWC46649.1 - 0.014 14.9 0.1 0.51 9.7 0.0 2.2 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain DUF815 PF05673.8 EWC46649.1 - 0.015 14.2 0.5 1.3 7.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) IstB_IS21 PF01695.12 EWC46649.1 - 0.024 14.0 0.5 4.5 6.6 0.0 3.5 4 0 0 4 4 3 0 IstB-like ATP binding protein AAA_14 PF13173.1 EWC46649.1 - 0.026 14.4 0.1 2.7 7.9 0.0 2.9 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.1 EWC46649.1 - 0.031 13.8 0.2 2.3 7.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.4 EWC46649.1 - 0.032 13.7 0.2 3.7 7.0 0.1 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation PRK PF00485.13 EWC46649.1 - 0.042 13.3 1.2 7.2 6.1 0.3 2.3 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family Dynamin_N PF00350.18 EWC46649.1 - 0.045 13.5 3.3 5.4 6.7 0.5 2.5 2 0 0 2 2 2 0 Dynamin family NTPase_1 PF03266.10 EWC46649.1 - 0.11 12.2 0.8 21 4.7 0.2 3.3 4 0 0 4 4 3 0 NTPase Gtr1_RagA PF04670.7 EWC46649.1 - 0.16 11.0 2.2 2.7 7.0 0.3 2.2 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region Sec23_trunk PF04811.10 EWC46650.1 - 1.1e-49 169.0 0.0 6.3e-49 166.5 0.0 2.0 1 1 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.10 EWC46650.1 - 7.9e-28 95.9 0.1 1.4e-27 95.1 0.1 1.4 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.7 EWC46650.1 - 2.4e-19 69.6 0.1 3.9e-19 68.9 0.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.10 EWC46650.1 - 2.6e-15 55.6 4.9 5.1e-15 54.7 3.4 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.17 EWC46650.1 - 1.1e-07 31.3 0.0 3.6e-07 29.7 0.0 1.8 1 0 0 1 1 1 1 Gelsolin repeat SLS PF14611.1 EWC46650.1 - 0.063 12.6 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial inner-membrane-bound regulator F-box-like PF12937.2 EWC46651.1 - 5.8e-10 38.7 2.1 8.4e-10 38.2 0.8 1.8 2 0 0 2 2 2 1 F-box-like F-box PF00646.28 EWC46651.1 - 0.0067 16.0 0.2 0.036 13.7 0.1 2.3 2 0 0 2 2 2 1 F-box domain F-box PF00646.28 EWC46652.1 - 0.0003 20.3 1.0 0.00074 19.1 0.4 2.0 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.2 EWC46652.1 - 0.0011 18.6 1.0 0.0031 17.2 0.7 1.8 1 0 0 1 1 1 1 F-box-like CedA PF10729.4 EWC46653.1 - 0.06 12.9 0.1 0.2 11.2 0.0 1.9 2 0 0 2 2 2 0 Cell division activator CedA LELP1 PF15042.1 EWC46654.1 - 0.056 13.6 0.4 0.091 12.9 0.3 1.3 1 0 0 1 1 1 0 Late cornified envelope-like proline-rich protein 1 BTB PF00651.26 EWC46655.1 - 1.4e-11 44.3 0.0 2.8e-11 43.4 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain DZR PF12773.2 EWC46655.1 - 0.17 11.6 0.8 0.31 10.8 0.5 1.4 1 0 0 1 1 1 0 Double zinc ribbon BTB PF00651.26 EWC46656.1 - 1.1e-12 47.9 0.0 1.7e-12 47.3 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain DUF3342 PF11822.3 EWC46656.1 - 0.057 12.5 0.0 0.057 12.5 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3342) DUF4470 PF14737.1 EWC46657.1 - 1.3e-20 73.0 0.0 2.6e-20 71.9 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4470) zf-MYND PF01753.13 EWC46657.1 - 1e-09 38.0 14.1 2.3e-09 36.9 9.8 1.6 1 0 0 1 1 1 1 MYND finger BTB PF00651.26 EWC46658.1 - 8.9e-16 57.8 0.0 1.5e-15 57.1 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain LRR_8 PF13855.1 EWC46659.1 - 0.00012 21.7 0.7 0.62 9.8 0.2 3.8 3 0 0 3 3 3 2 Leucine rich repeat NinB PF05772.7 EWC46659.1 - 0.036 13.6 0.1 0.43 10.2 0.0 2.3 2 0 0 2 2 2 0 NinB protein PRANC PF09372.5 EWC46659.1 - 0.11 12.4 0.0 0.27 11.2 0.0 1.6 1 0 0 1 1 1 0 PRANC domain F-box-like PF12937.2 EWC46659.1 - 0.17 11.6 2.6 0.38 10.5 0.0 2.9 3 0 0 3 3 3 0 F-box-like GFA PF04828.9 EWC46660.1 - 1.3e-16 60.2 0.7 7.8e-07 28.9 0.0 3.5 2 1 0 2 2 2 2 Glutathione-dependent formaldehyde-activating enzyme GST_C_3 PF14497.1 EWC46662.1 - 0.00034 21.0 0.0 0.00059 20.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 EWC46662.1 - 0.0024 17.7 0.0 0.006 16.4 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.1 EWC46662.1 - 0.0053 16.9 0.0 0.024 14.8 0.0 2.0 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Dicty_REP PF05086.7 EWC46664.1 - 4.5 4.8 24.7 6.4 4.3 17.1 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF3367 PF11847.3 EWC46664.1 - 5.7 4.7 15.2 9.3 4.0 10.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3367) Treslin_N PF15292.1 EWC46668.1 - 0.002 16.1 0.4 0.0027 15.6 0.3 1.1 1 0 0 1 1 1 1 Treslin N-terminus BTB PF00651.26 EWC46671.1 - 1.1e-08 35.0 0.0 2e-08 34.2 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain p450 PF00067.17 EWC46673.1 - 1.6e-57 195.0 0.0 2.1e-57 194.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Aldedh PF00171.17 EWC46678.1 - 2.9e-140 467.6 0.0 3.5e-140 467.4 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.9 EWC46678.1 - 0.0012 17.7 0.0 0.0061 15.3 0.0 1.8 1 1 0 1 1 1 1 Acyl-CoA reductase (LuxC) CBM_1 PF00734.13 EWC46681.1 - 4.9e-12 45.2 13.8 4.9e-12 45.2 9.6 2.5 2 0 0 2 2 2 1 Fungal cellulose binding domain Esterase PF00756.15 EWC46681.1 - 7e-07 28.9 0.4 3.5e-06 26.6 0.3 1.9 1 1 0 1 1 1 1 Putative esterase Abhydrolase_2 PF02230.11 EWC46681.1 - 0.00018 21.0 0.0 0.00031 20.2 0.0 1.3 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_5 PF12695.2 EWC46681.1 - 0.00029 20.5 0.0 0.00051 19.8 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF3439 PF11921.3 EWC46681.1 - 0.015 15.0 16.6 0.034 13.8 11.5 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Abhydrolase_6 PF12697.2 EWC46681.1 - 0.035 13.9 0.0 0.059 13.2 0.0 1.4 1 1 0 1 1 1 0 Alpha/beta hydrolase family Esterase_phd PF10503.4 EWC46681.1 - 0.035 13.3 0.1 0.16 11.2 0.0 2.0 2 0 0 2 2 2 0 Esterase PHB depolymerase Abhydrolase_1 PF00561.15 EWC46681.1 - 0.042 13.4 0.0 0.061 12.8 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold SSP160 PF06933.6 EWC46681.1 - 0.24 9.3 22.3 0.34 8.8 15.4 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Dicty_REP PF05086.7 EWC46681.1 - 0.54 7.9 6.9 0.68 7.6 4.8 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein MSP1_C PF07462.6 EWC46681.1 - 3.9 5.7 3.9 5.3 5.3 2.7 1.1 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus Zn_clus PF00172.13 EWC46682.1 - 0.21 11.5 12.5 0.17 11.8 7.5 1.8 2 1 0 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_hydro_7 PF00840.15 EWC46684.1 - 6.2e-144 479.5 4.8 7.8e-144 479.2 3.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 7 CPSF100_C PF13299.1 EWC46685.1 - 9.9e-29 100.5 0.2 2.8e-27 95.8 0.0 2.6 2 0 0 2 2 2 1 Cleavage and polyadenylation factor 2 C-terminal Beta-Casp PF10996.3 EWC46685.1 - 2.4e-23 82.4 0.0 6.5e-23 81.0 0.0 1.7 1 0 0 1 1 1 1 Beta-Casp domain Lactamase_B PF00753.22 EWC46685.1 - 0.00024 20.8 1.2 0.00045 19.9 0.1 2.0 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily RMMBL PF07521.7 EWC46685.1 - 0.00053 19.7 0.0 0.001 18.8 0.0 1.4 1 0 0 1 1 1 1 RNA-metabolising metallo-beta-lactamase TRAP_alpha PF03896.11 EWC46685.1 - 0.099 11.6 0.1 0.16 10.9 0.1 1.4 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit PBP PF01161.15 EWC46687.1 - 6.7e-20 71.4 0.0 1.2e-19 70.6 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein YhhN PF07947.9 EWC46688.1 - 7.8e-30 103.6 7.6 1.3e-28 99.6 5.3 2.2 1 1 0 1 1 1 1 YhhN-like protein DUF1002 PF06207.6 EWC46696.1 - 5.4 6.2 9.4 9.2 5.5 6.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1002) ACT_5 PF13710.1 EWC46698.1 - 0.022 14.5 0.0 6.3 6.6 0.0 2.2 2 0 0 2 2 2 0 ACT domain GP41 PF00517.12 EWC46699.1 - 0.018 14.5 0.1 0.028 14.0 0.1 1.2 1 0 0 1 1 1 0 Retroviral envelope protein Orthoreo_P10 PF07204.6 EWC46699.1 - 0.02 14.6 0.2 0.036 13.7 0.2 1.4 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 Herpes_gE PF02480.11 EWC46699.1 - 0.033 12.4 0.2 0.066 11.4 0.2 1.4 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E TMEM52 PF14979.1 EWC46699.1 - 0.16 11.8 3.9 0.31 10.9 2.7 1.4 1 0 0 1 1 1 0 Transmembrane 52 Adeno_E3_CR2 PF02439.10 EWC46699.1 - 1.5 8.4 8.7 2.4 7.7 6.0 1.2 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Corona_nucleoca PF00937.13 EWC46700.1 - 0.11 11.4 1.5 0.099 11.5 1.0 1.0 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein MBD PF01429.14 EWC46700.1 - 0.11 12.0 0.1 0.15 11.6 0.1 1.2 1 0 0 1 1 1 0 Methyl-CpG binding domain ApoO PF09769.4 EWC46701.1 - 1.5e-37 128.7 0.4 3.3e-37 127.6 0.0 1.6 2 0 0 2 2 2 1 Apolipoprotein O RNA_pol_Rpb2_6 PF00562.23 EWC46702.1 - 1e-108 363.5 0.3 1.7e-108 362.8 0.2 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.10 EWC46702.1 - 4.7e-34 117.1 0.0 6.8e-34 116.5 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpa2_4 PF06883.7 EWC46702.1 - 1.2e-25 89.1 0.0 2.7e-25 88.0 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_3 PF04565.11 EWC46702.1 - 1.9e-24 85.2 0.0 4.5e-24 83.9 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_2 PF04561.9 EWC46702.1 - 1.7e-21 76.5 0.1 3.3e-21 75.5 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.15 EWC46702.1 - 2.6e-13 50.0 0.0 8.6e-13 48.3 0.0 1.9 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_5 PF04567.12 EWC46702.1 - 0.066 13.1 0.4 0.2 11.6 0.0 2.1 2 0 0 2 2 2 0 RNA polymerase Rpb2, domain 5 zf-MYND PF01753.13 EWC46704.1 - 7.4e-08 32.1 10.8 1.2e-07 31.4 7.5 1.3 1 0 0 1 1 1 1 MYND finger hSac2 PF12456.3 EWC46704.1 - 0.074 12.4 0.0 2.8 7.3 0.0 2.5 2 0 0 2 2 2 0 Inositol phosphatase PolC_DP2 PF03833.8 EWC46704.1 - 0.2 9.2 0.4 0.27 8.8 0.3 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 Pil1 PF13805.1 EWC46705.1 - 3e-98 328.2 2.5 4.3e-98 327.7 1.7 1.1 1 0 0 1 1 1 1 Eisosome component PIL1 FAM92 PF06730.6 EWC46705.1 - 0.0074 15.6 2.0 0.012 15.0 1.4 1.3 1 0 0 1 1 1 1 FAM92 protein SWI-SNF_Ssr4 PF08549.5 EWC46706.1 - 6.8e-27 94.0 7.9 6.8e-27 94.0 5.5 2.7 2 1 1 3 3 3 1 Fungal domain of unknown function (DUF1750) TFIIA PF03153.8 EWC46706.1 - 5.9 6.6 7.9 11 5.8 1.9 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit KAR9 PF08580.5 EWC46707.1 - 7e-89 298.9 18.9 1.5e-87 294.5 13.0 2.0 1 1 0 1 1 1 1 Yeast cortical protein KAR9 Spectrin PF00435.16 EWC46707.1 - 5.4e-06 26.6 5.2 0.012 15.8 0.0 3.4 3 0 0 3 3 3 2 Spectrin repeat Enkurin PF13864.1 EWC46707.1 - 0.11 12.7 0.8 8.8 6.6 0.0 3.4 3 0 0 3 3 3 0 Calmodulin-binding DUF964 PF06133.6 EWC46707.1 - 0.18 11.8 3.1 0.62 10.1 0.1 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF964) Prefoldin_2 PF01920.15 EWC46707.1 - 0.43 10.3 4.0 4.4 7.1 0.4 3.2 4 0 0 4 4 4 0 Prefoldin subunit AAA_13 PF13166.1 EWC46707.1 - 1.4 7.2 4.8 1.1 7.6 1.1 2.0 2 0 0 2 2 2 0 AAA domain DUF1212 PF06738.7 EWC46708.1 - 7.3e-38 129.9 8.9 6.4e-36 123.6 0.4 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF1212) DUF3815 PF12821.2 EWC46708.1 - 2.4e-16 59.8 12.6 2.4e-16 59.8 8.7 2.7 3 0 0 3 3 3 2 Protein of unknown function (DUF3815) Neurensin PF14927.1 EWC46708.1 - 0.014 14.7 0.9 0.053 12.8 0.6 2.0 1 0 0 1 1 1 0 Neurensin UDG PF03167.14 EWC46709.1 - 1.2e-21 76.7 0.1 2.2e-21 75.9 0.1 1.4 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily Thioredoxin PF00085.15 EWC46710.1 - 1.6e-61 204.4 5.3 2.7e-31 107.3 0.2 4.1 4 0 0 4 4 4 2 Thioredoxin Thioredoxin_6 PF13848.1 EWC46710.1 - 1.9e-51 174.4 0.1 1.1e-37 129.6 0.0 3.3 2 1 1 3 3 3 3 Thioredoxin-like domain Calsequestrin PF01216.12 EWC46710.1 - 4.9e-13 48.6 0.1 1.6e-12 46.8 0.0 1.8 2 0 0 2 2 2 1 Calsequestrin Thioredoxin_7 PF13899.1 EWC46710.1 - 6.1e-13 48.5 0.5 1.1e-05 25.3 0.0 3.1 2 1 0 2 2 2 2 Thioredoxin-like Thioredoxin_8 PF13905.1 EWC46710.1 - 1.6e-12 47.3 0.4 0.00018 21.5 0.0 4.2 4 1 0 4 4 4 2 Thioredoxin-like Thioredoxin_2 PF13098.1 EWC46710.1 - 4.7e-10 39.6 5.4 6.7e-05 23.0 0.3 4.7 2 2 0 2 2 2 2 Thioredoxin-like domain AhpC-TSA PF00578.16 EWC46710.1 - 2.8e-07 30.2 1.3 0.0016 18.0 0.1 3.0 2 1 0 2 2 2 2 AhpC/TSA family ERp29_N PF07912.8 EWC46710.1 - 9.1e-07 28.8 0.3 0.0071 16.2 0.0 3.5 4 1 0 4 4 4 2 ERp29, N-terminal domain Redoxin PF08534.5 EWC46710.1 - 0.00026 20.5 8.1 0.092 12.2 0.1 3.5 3 1 0 4 4 4 2 Redoxin Thioredoxin_4 PF13462.1 EWC46710.1 - 0.004 17.1 2.6 6.2 6.8 0.1 4.2 3 2 1 4 4 4 1 Thioredoxin DUF4259 PF14078.1 EWC46710.1 - 1.2 9.6 5.3 1.4 9.4 0.0 3.0 4 1 0 4 4 3 0 Domain of unknown function (DUF4259) Hydantoinase_B PF02538.9 EWC46711.1 - 7.2e-205 681.1 0.0 1e-204 680.7 0.0 1.1 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.13 EWC46711.1 - 3.8e-94 315.0 0.3 7.8e-94 314.0 0.2 1.6 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.8 EWC46711.1 - 2.8e-59 199.5 1.9 7.4e-58 194.9 0.0 2.8 3 0 0 3 3 3 1 Hydantoinase/oxoprolinase N-terminal region GRASP55_65 PF04495.9 EWC46712.1 - 2.3e-46 157.1 0.0 1.1e-44 151.7 0.0 2.1 1 1 1 2 2 2 2 GRASP55/65 PDZ-like domain PCI PF01399.22 EWC46713.1 - 4.2e-08 33.4 0.0 9.9e-08 32.2 0.0 1.6 1 0 0 1 1 1 1 PCI domain DUF3554 PF12074.3 EWC46714.1 - 2.7e-56 191.4 0.0 4.5e-55 187.4 0.0 3.0 2 0 0 2 2 2 1 Domain of unknown function (DUF3554) HEAT PF02985.17 EWC46714.1 - 1e-36 121.6 29.4 0.093 12.8 0.0 22.6 25 0 0 25 25 25 8 HEAT repeat HEAT_2 PF13646.1 EWC46714.1 - 3.6e-35 120.1 47.2 1.8e-08 34.5 0.0 17.8 13 4 6 19 19 19 9 HEAT repeats HEAT_EZ PF13513.1 EWC46714.1 - 5.5e-31 106.2 37.7 0.00053 20.3 0.0 21.9 20 5 5 25 25 24 6 HEAT-like repeat Vac14_Fab1_bd PF12755.2 EWC46714.1 - 1.1e-13 51.3 0.0 1.7 9.0 0.0 9.2 9 2 1 10 10 8 3 Vacuolar 14 Fab1-binding region CLASP_N PF12348.3 EWC46714.1 - 5.9e-10 38.8 0.0 0.12 11.6 0.0 6.6 5 1 1 7 7 7 3 CLASP N terminal Cnd1 PF12717.2 EWC46714.1 - 2.5e-09 37.2 0.0 7.9 6.2 0.0 8.4 7 2 1 8 8 7 2 non-SMC mitotic condensation complex subunit 1 ParcG PF10274.4 EWC46714.1 - 3.9e-07 30.1 0.9 0.089 12.6 0.0 5.8 6 0 0 6 6 6 2 Parkin co-regulated protein Adaptin_N PF01602.15 EWC46714.1 - 4.9e-06 25.1 15.3 0.68 8.1 0.0 9.2 8 3 1 10 10 10 3 Adaptin N terminal region UME PF08064.8 EWC46714.1 - 9.3e-05 22.3 0.6 6 6.8 0.0 6.4 5 2 2 7 7 7 1 UME (NUC010) domain Ecm29 PF13001.2 EWC46714.1 - 0.00099 17.7 1.6 0.019 13.4 0.0 4.0 5 0 0 5 5 5 1 Proteasome stabiliser RasGEF_N_2 PF14663.1 EWC46714.1 - 0.0073 16.2 0.0 0.093 12.6 0.0 3.0 3 0 0 3 3 2 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain MMS19_N PF14500.1 EWC46714.1 - 0.011 14.9 7.7 4.7 6.4 0.0 6.7 10 0 0 10 10 10 0 Dos2-interacting transcription regulator of RNA-Pol-II DUF2435 PF10363.4 EWC46714.1 - 0.71 9.8 11.0 25 4.8 0.1 7.1 6 2 2 8 8 8 0 Protein of unknown function (DUF2435) MMS19_C PF12460.3 EWC46714.1 - 5.2 5.6 16.5 21 3.6 0.0 7.1 8 0 0 8 8 8 0 RNAPII transcription regulator C-terminal BRCT PF00533.21 EWC46715.1 - 1.2e-05 25.3 0.0 4.8e-05 23.4 0.0 2.0 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.2 EWC46715.1 - 0.00017 21.3 1.2 0.00067 19.4 0.1 2.4 3 0 0 3 3 3 1 twin BRCT domain KilA-N PF04383.8 EWC46716.1 - 0.00073 19.1 0.0 0.0074 15.8 0.0 2.2 1 1 0 1 1 1 1 KilA-N domain PC4 PF02229.11 EWC46717.1 - 3.3e-21 74.2 0.1 3.3e-21 74.2 0.0 2.4 2 0 0 2 2 2 1 Transcriptional Coactivator p15 (PC4) FLO_LFY PF01698.11 EWC46717.1 - 3.4 6.4 13.6 5.9 5.6 9.5 1.5 1 0 0 1 1 1 0 Floricaula / Leafy protein PBP_sp32 PF07222.7 EWC46717.1 - 9.5 5.3 14.7 14 4.7 10.2 1.2 1 0 0 1 1 1 0 Proacrosin binding protein sp32 MIT PF04212.13 EWC46718.1 - 4.7e-07 29.5 0.2 1.1e-06 28.4 0.1 1.7 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain DDHD PF02862.12 EWC46719.1 - 1.4e-63 214.7 0.0 2.5e-63 213.9 0.0 1.4 1 0 0 1 1 1 1 DDHD domain Hamartin PF04388.7 EWC46720.1 - 4.6 5.7 13.1 5.6 5.5 9.1 1.1 1 0 0 1 1 1 0 Hamartin protein DUF605 PF04652.11 EWC46721.1 - 1.5 8.1 8.0 1.7 7.9 5.5 1.1 1 0 0 1 1 1 0 Vta1 like Mito_carr PF00153.22 EWC46723.1 - 8.6e-66 217.7 2.7 1.4e-21 75.9 0.1 4.1 4 0 0 4 4 4 4 Mitochondrial carrier protein YtxH PF12732.2 EWC46723.1 - 0.017 15.4 0.1 0.032 14.5 0.1 1.4 1 0 0 1 1 1 0 YtxH-like protein GST_N_3 PF13417.1 EWC46724.1 - 1.5e-10 41.1 0.0 3.5e-10 39.9 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 EWC46724.1 - 4.5e-05 23.3 0.0 9.3e-05 22.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Fe-S_assembly PF04384.8 EWC46724.1 - 0.28 11.5 1.4 11 6.4 0.1 2.4 1 1 1 2 2 2 0 Iron-sulphur cluster assembly Tyrosinase PF00264.15 EWC46726.1 - 5e-37 128.2 0.8 7.9e-37 127.5 0.5 1.4 1 0 0 1 1 1 1 Common central domain of tyrosinase Sugar_tr PF00083.19 EWC46727.1 - 1.7e-50 171.9 18.0 2.2e-48 164.9 12.5 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter NfeD PF01957.13 EWC46727.1 - 4.1 7.5 10.3 5.8 7.0 0.0 3.3 3 0 0 3 3 3 0 NfeD-like C-terminal, partner-binding DUF1479 PF07350.7 EWC46728.1 - 2e-114 382.3 0.0 2.4e-114 382.0 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1479) PhyH PF05721.8 EWC46728.1 - 0.008 16.2 0.1 0.18 11.8 0.1 2.7 2 1 0 2 2 2 1 Phytanoyl-CoA dioxygenase (PhyH) DUF1370 PF07114.6 EWC46730.1 - 0.14 11.3 0.0 0.17 11.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1370) Actin PF00022.14 EWC46731.1 - 6e-127 423.3 0.0 6.8e-127 423.1 0.0 1.0 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.8 EWC46731.1 - 0.0036 15.9 0.0 1.4 7.3 0.0 2.3 2 0 0 2 2 2 2 MreB/Mbl protein MBOAT PF03062.14 EWC46732.1 - 1.6e-40 139.1 16.3 1.6e-40 139.1 11.3 1.8 2 1 0 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.1 EWC46732.1 - 0.037 14.1 2.0 0.12 12.4 1.4 1.9 1 0 0 1 1 1 0 Membrane bound O-acyl transferase family Helicase_C PF00271.26 EWC46733.1 - 3.3e-21 74.9 0.1 5.6e-18 64.5 0.0 2.7 2 0 0 2 2 2 2 Helicase conserved C-terminal domain DEAD PF00270.24 EWC46733.1 - 2.1e-20 72.9 0.5 5.1e-20 71.6 0.1 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase RQC PF09382.5 EWC46733.1 - 3.4e-18 65.2 0.0 3.1e-17 62.2 0.0 2.3 2 0 0 2 2 2 1 RQC domain SNF2_N PF00176.18 EWC46733.1 - 0.00047 19.0 0.0 0.00074 18.3 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain NOD PF06816.8 EWC46733.1 - 0.037 13.1 0.0 0.083 11.9 0.0 1.5 1 0 0 1 1 1 0 NOTCH protein F-box-like PF12937.2 EWC46734.1 - 5.1e-06 26.0 0.0 9.5e-06 25.2 0.0 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EWC46734.1 - 0.012 15.2 0.0 0.027 14.1 0.0 1.6 1 0 0 1 1 1 0 F-box domain Kinesin PF00225.18 EWC46735.1 - 4.7e-54 183.3 0.0 1e-29 103.2 0.0 2.1 2 0 0 2 2 2 2 Kinesin motor domain Kelch_4 PF13418.1 EWC46736.1 - 2.9e-08 33.3 19.2 0.0029 17.3 0.4 5.6 4 2 1 5 5 5 4 Galactose oxidase, central domain Kelch_5 PF13854.1 EWC46736.1 - 2.6e-07 30.4 2.2 8.9e-05 22.3 0.1 3.5 3 0 0 3 3 3 2 Kelch motif Kelch_3 PF13415.1 EWC46736.1 - 0.019 15.1 9.6 3.2 8.0 0.1 4.9 4 0 0 4 4 4 0 Galactose oxidase, central domain Sensor PF13796.1 EWC46736.1 - 0.064 12.8 0.3 0.11 12.0 0.2 1.3 1 0 0 1 1 1 0 Putative sensor Phage_HK97_TLTM PF06120.6 EWC46736.1 - 0.22 10.7 0.1 0.34 10.1 0.1 1.2 1 0 0 1 1 1 0 Tail length tape measure protein Herpes_gE PF02480.11 EWC46736.1 - 0.27 9.4 0.0 0.39 8.9 0.0 1.1 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E Kelch_1 PF01344.20 EWC46736.1 - 0.62 9.6 7.6 3.8 7.1 0.1 4.1 5 0 0 5 5 5 0 Kelch motif CVNH PF08881.5 EWC46737.1 - 1.5e-11 44.4 0.0 2.7e-11 43.6 0.0 1.3 1 0 0 1 1 1 1 CVNH domain Gly_transf_sug PF04488.10 EWC46738.1 - 1e-07 32.2 0.0 2.2e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif TcdA_TcdB PF12919.2 EWC46738.1 - 0.042 12.3 0.0 0.066 11.6 0.0 1.2 1 0 0 1 1 1 0 TcdA/TcdB catalytic glycosyltransferase domain Herpes_capsid PF06112.6 EWC46738.1 - 3.4 7.6 5.9 6.2 6.8 4.1 1.3 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein PLRV_ORF5 PF01690.12 EWC46739.1 - 5.7 5.9 18.1 6.9 5.6 12.6 1.1 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein Proteasome PF00227.21 EWC46740.1 - 1.7e-48 164.4 0.1 2.1e-48 164.1 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Mon1 PF03164.9 EWC46742.1 - 8.5e-130 433.0 0.0 1e-129 432.7 0.0 1.0 1 0 0 1 1 1 1 Trafficking protein Mon1 Dopey_N PF04118.9 EWC46743.1 - 3.7e-115 383.9 0.1 4.2e-114 380.4 0.0 2.5 2 1 1 3 3 3 1 Dopey, N-terminal CENP-K PF11802.3 EWC46744.1 - 8.6e-08 31.7 0.0 0.002 17.4 0.0 2.3 2 0 0 2 2 2 2 Centromere-associated protein K Spc7 PF08317.6 EWC46744.1 - 0.014 14.0 6.5 0.028 13.0 4.2 1.7 1 1 1 2 2 2 0 Spc7 kinetochore protein Rep_fac-A_C PF08646.5 EWC46744.1 - 0.1 12.3 0.4 0.28 10.8 0.0 1.9 2 0 0 2 2 2 0 Replication factor-A C terminal domain DUF745 PF05335.8 EWC46744.1 - 2.3 7.6 10.8 3.2 7.2 3.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF745) GAS PF13851.1 EWC46744.1 - 3.4 6.8 12.5 0.55 9.4 5.1 2.0 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding DUF904 PF06005.7 EWC46744.1 - 4.4 7.6 9.7 3.9 7.8 4.9 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF904) DivIVA PF05103.8 EWC46744.1 - 7.6 6.5 13.8 38 4.3 0.1 2.4 2 0 0 2 2 2 0 DivIVA protein Pyridoxal_deC PF00282.14 EWC46745.1 - 4.2e-31 107.7 0.0 8.9e-31 106.6 0.0 1.5 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.16 EWC46745.1 - 0.00046 19.4 0.0 0.00061 19.0 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase CholecysA-Rec_N PF09193.5 EWC46745.1 - 0.051 13.4 0.0 0.14 12.0 0.0 1.7 1 0 0 1 1 1 0 Cholecystokinin A receptor, N-terminal NPP1 PF05630.6 EWC46747.1 - 0.00013 21.7 1.5 0.00031 20.5 1.0 1.5 1 1 0 1 1 1 1 Necrosis inducing protein (NPP1) HA2 PF04408.18 EWC46748.1 - 1.4e-15 57.1 2.9 5.1e-15 55.3 0.0 2.9 3 0 0 3 3 3 1 Helicase associated domain (HA2) Helicase_C PF00271.26 EWC46748.1 - 2.2e-13 49.8 0.2 7.2e-13 48.2 0.1 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.11 EWC46748.1 - 1.8e-09 37.4 0.0 5.2e-09 35.9 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.24 EWC46748.1 - 3.4e-08 33.1 0.0 1.3e-07 31.2 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.1 EWC46748.1 - 2.3e-05 24.5 0.0 7e-05 22.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.1 EWC46748.1 - 0.0044 16.5 0.0 0.0098 15.3 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_30 PF13604.1 EWC46748.1 - 0.012 15.2 0.0 0.024 14.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.22 EWC46748.1 - 0.035 14.4 0.1 0.17 12.1 0.1 2.2 1 0 0 1 1 1 0 ABC transporter DUF258 PF03193.11 EWC46748.1 - 0.097 11.8 0.0 0.18 10.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 Lipase_GDSL_2 PF13472.1 EWC46749.1 - 0.0055 16.8 0.0 0.01 15.9 0.0 1.5 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family GTP_EFTU PF00009.22 EWC46751.1 - 8.5e-08 31.8 0.0 1.6e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 EWC46751.1 - 0.0022 17.9 0.0 0.0049 16.8 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.11 EWC46751.1 - 0.16 11.1 0.1 0.34 10.0 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 DUF3567 PF12091.3 EWC46752.1 - 0.12 12.3 0.0 0.21 11.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3567) KH_1 PF00013.24 EWC46754.1 - 1.5e-28 98.2 8.9 4.5e-17 61.4 0.2 3.3 3 0 0 3 3 3 3 KH domain KH_3 PF13014.1 EWC46754.1 - 9.6e-18 63.4 13.3 3.4e-12 45.7 1.4 3.5 3 0 0 3 3 3 2 KH domain KH_2 PF07650.12 EWC46754.1 - 3e-09 36.2 1.4 0.0014 18.1 0.0 2.4 2 0 0 2 2 2 2 KH domain KH_4 PF13083.1 EWC46754.1 - 4.3e-05 23.0 0.2 0.063 12.9 0.0 2.5 2 0 0 2 2 2 2 KH domain KH_5 PF13184.1 EWC46754.1 - 0.052 13.3 1.2 0.72 9.6 0.1 2.5 2 0 0 2 2 2 0 NusA-like KH domain MR_MLE_N PF02746.11 EWC46754.1 - 0.093 12.7 0.1 7.3 6.6 0.0 2.4 2 0 0 2 2 2 0 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain DUF605 PF04652.11 EWC46755.1 - 0.039 13.3 4.1 0.052 12.9 2.8 1.1 1 0 0 1 1 1 0 Vta1 like DUF2749 PF10907.3 EWC46755.1 - 6 6.8 6.5 3 7.7 0.2 3.0 4 0 0 4 4 4 0 Protein of unknown function (DUF2749) LRR_4 PF12799.2 EWC46756.1 - 0.23 11.0 6.0 2.1 8.0 0.3 4.5 5 1 0 5 5 5 0 Leucine Rich repeats (2 copies) Ank_2 PF12796.2 EWC46757.1 - 1.4e-76 252.9 24.0 1.1e-12 48.1 0.0 14.9 5 3 8 13 13 13 13 Ankyrin repeats (3 copies) Ank PF00023.25 EWC46757.1 - 4.4e-36 120.8 41.5 0.018 14.7 0.0 24.0 31 1 0 31 31 31 10 Ankyrin repeat Ank_4 PF13637.1 EWC46757.1 - 2.4e-23 82.0 23.2 0.12 12.8 0.1 14.2 13 3 4 17 17 17 8 Ankyrin repeats (many copies) Ank_3 PF13606.1 EWC46757.1 - 4.2e-23 79.1 18.7 0.41 11.0 0.1 20.4 26 1 1 27 27 27 5 Ankyrin repeat Ank_5 PF13857.1 EWC46757.1 - 1e-18 66.9 26.8 0.0019 18.3 0.0 15.6 12 2 4 16 16 16 6 Ankyrin repeats (many copies) Shigella_OspC PF06128.6 EWC46757.1 - 0.017 14.6 0.1 18 4.6 0.0 3.4 3 0 0 3 3 3 0 Shigella flexneri OspC protein Fungal_trans PF04082.13 EWC46760.1 - 6.1e-12 44.9 0.1 1.2e-11 43.9 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EWC46760.1 - 7e-08 32.2 9.1 1.2e-07 31.4 6.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Proteasome PF00227.21 EWC46761.1 - 3.9e-45 153.4 0.1 5e-45 153.1 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.3 EWC46761.1 - 7.4e-10 37.9 0.3 1.9e-09 36.6 0.2 1.7 1 0 0 1 1 1 1 Proteasome beta subunits C terminal Cullin PF00888.17 EWC46763.1 - 2.5e-32 112.1 0.0 5.4e-32 111.0 0.0 1.4 2 0 0 2 2 2 1 Cullin family APC2 PF08672.6 EWC46763.1 - 2.7e-07 30.7 0.0 7.7e-07 29.2 0.0 1.8 1 0 0 1 1 1 1 Anaphase promoting complex (APC) subunit 2 Cse1 PF08506.5 EWC46763.1 - 0.059 11.9 0.1 1.4 7.3 0.0 2.2 2 0 0 2 2 2 0 Cse1 GMC_oxred_N PF00732.14 EWC46764.1 - 1.1e-62 211.9 0.0 1.5e-62 211.4 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.8 EWC46764.1 - 2.6e-30 105.6 0.0 5.6e-30 104.5 0.0 1.6 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.19 EWC46764.1 - 3.2e-05 22.9 1.6 0.0052 15.6 0.4 2.3 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.19 EWC46764.1 - 0.00018 20.5 0.2 0.051 12.4 0.0 2.4 2 0 0 2 2 2 2 FAD dependent oxidoreductase Lycopene_cycl PF05834.7 EWC46764.1 - 0.0022 16.9 0.3 0.0035 16.3 0.2 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.1 EWC46764.1 - 0.012 15.6 0.2 0.029 14.4 0.2 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain TrkA_N PF02254.13 EWC46764.1 - 0.13 12.2 0.0 0.26 11.2 0.0 1.4 1 0 0 1 1 1 0 TrkA-N domain Pyr_redox_2 PF07992.9 EWC46764.1 - 0.14 12.0 0.0 1.1 9.1 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 EWC46764.1 - 0.14 12.1 0.3 9.9 6.1 0.2 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FMN_dh PF01070.13 EWC46765.1 - 2.8e-116 388.2 0.0 3.4e-116 387.9 0.0 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Glu_synthase PF01645.12 EWC46765.1 - 6.2e-05 22.0 0.2 8.7e-05 21.5 0.1 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.20 EWC46765.1 - 0.00037 19.5 0.2 0.0032 16.4 0.2 2.2 2 1 1 3 3 3 1 IMP dehydrogenase / GMP reductase domain ThiG PF05690.9 EWC46765.1 - 0.0018 17.3 0.1 0.0047 16.0 0.1 1.6 2 0 0 2 2 2 1 Thiazole biosynthesis protein ThiG IGPS PF00218.16 EWC46765.1 - 0.015 14.4 0.0 0.027 13.5 0.0 1.3 1 0 0 1 1 1 0 Indole-3-glycerol phosphate synthase NMO PF03060.10 EWC46765.1 - 0.16 11.0 1.3 0.25 10.4 0.9 1.2 1 0 0 1 1 1 0 Nitronate monooxygenase PMI_typeI PF01238.16 EWC46766.1 - 5.4e-63 213.2 0.0 6.4e-63 212.9 0.0 1.0 1 0 0 1 1 1 1 Phosphomannose isomerase type I Herpes_UL87 PF03043.9 EWC46766.1 - 0.00033 19.1 0.5 0.00049 18.6 0.3 1.1 1 0 0 1 1 1 1 Herpesvirus UL87 family Cupin_2 PF07883.6 EWC46766.1 - 0.0015 17.9 0.2 1.5 8.3 0.0 2.8 3 0 0 3 3 3 2 Cupin domain Tmemb_cc2 PF10267.4 EWC46766.1 - 0.063 11.8 0.6 0.09 11.3 0.4 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein Syntaxin PF00804.20 EWC46766.1 - 0.1 12.7 1.2 0.15 12.2 0.3 1.6 2 0 0 2 2 2 0 Syntaxin GlutR_dimer PF00745.15 EWC46766.1 - 0.14 12.1 0.4 0.33 10.9 0.3 1.6 1 0 0 1 1 1 0 Glutamyl-tRNAGlu reductase, dimerisation domain DUF2317 PF10079.4 EWC46766.1 - 0.15 10.6 0.7 0.22 10.1 0.5 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2317) Melibiase PF02065.13 EWC46767.1 - 1.1e-45 156.0 0.1 7.1e-23 80.9 0.0 2.5 1 1 2 3 3 3 2 Melibiase ADIP PF11559.3 EWC46768.1 - 0.0052 16.7 31.3 0.038 13.8 4.9 3.5 3 1 1 4 4 4 4 Afadin- and alpha -actinin-Binding DUF2681 PF10883.3 EWC46768.1 - 0.011 15.9 3.1 0.011 15.9 2.1 3.8 3 2 1 4 4 4 0 Protein of unknown function (DUF2681) Phage_GP20 PF06810.6 EWC46768.1 - 0.036 13.4 0.3 0.036 13.4 0.2 3.5 1 1 2 3 3 3 0 Phage minor structural protein GP20 Vac_Fusion PF02346.11 EWC46768.1 - 0.24 10.8 13.1 0.33 10.4 0.1 4.9 3 2 1 5 5 5 0 Chordopoxvirus fusion protein Flu_NS2 PF00601.14 EWC46768.1 - 0.51 10.5 0.1 0.51 10.5 0.0 3.1 2 1 0 3 3 3 0 Influenza non-structural protein (NS2) GIDA_assoc_3 PF13932.1 EWC46768.1 - 0.66 10.0 3.8 0.54 10.3 0.3 2.6 2 0 0 2 2 2 0 GidA associated domain 3 IncA PF04156.9 EWC46768.1 - 0.67 9.5 29.0 0.29 10.7 4.5 3.1 2 1 1 3 3 3 0 IncA protein V_ATPase_I PF01496.14 EWC46768.1 - 1.3 6.7 14.6 1.4 6.6 6.9 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family SlyX PF04102.7 EWC46768.1 - 1.7 9.0 20.5 1.1 9.6 0.1 5.0 5 1 1 6 6 5 0 SlyX G-gamma PF00631.17 EWC46768.1 - 1.8 8.3 6.5 21 4.9 0.0 3.3 3 0 0 3 3 3 0 GGL domain DUF3391 PF11871.3 EWC46768.1 - 3.2 7.9 11.0 0.16 12.2 1.9 2.8 1 1 2 3 3 3 0 Domain of unknown function (DUF3391) zf-BED PF02892.10 EWC46769.1 - 0.21 11.3 12.4 5.1 6.9 0.3 3.7 2 1 2 4 4 4 0 BED zinc finger zf-Mss51 PF13824.1 EWC46769.1 - 0.21 11.4 13.2 5.4 6.9 6.1 3.5 2 1 0 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 Kazal_1 PF00050.16 EWC46769.1 - 0.24 11.4 4.7 1.6 8.8 0.1 2.9 2 1 0 2 2 2 0 Kazal-type serine protease inhibitor domain DNA_RNApol_7kD PF03604.8 EWC46769.1 - 0.4 10.1 3.7 1.3 8.5 0.1 2.8 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit ATP-synt_E PF05680.7 EWC46769.1 - 8.7 6.3 8.4 2.1 8.3 2.0 2.3 2 0 0 2 2 2 0 ATP synthase E chain AAA PF00004.24 EWC46772.1 - 8e-16 58.4 0.0 1.8e-15 57.3 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 EWC46772.1 - 0.003 17.6 1.8 0.03 14.4 0.1 2.5 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.9 EWC46772.1 - 0.0072 16.0 0.0 0.017 14.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 EWC46772.1 - 0.013 15.5 2.1 0.028 14.3 0.1 2.3 2 1 1 3 3 3 0 AAA ATPase domain AAA_17 PF13207.1 EWC46772.1 - 0.035 14.9 0.0 0.21 12.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain NACHT PF05729.7 EWC46772.1 - 0.089 12.4 0.1 0.48 10.0 0.0 2.2 3 0 0 3 3 3 0 NACHT domain APG17 PF04108.7 EWC46775.1 - 0.022 13.5 0.0 0.036 12.8 0.0 1.3 1 0 0 1 1 1 0 Autophagy protein Apg17 Fib_alpha PF08702.5 EWC46775.1 - 0.054 13.6 0.5 5.6 7.0 0.0 2.2 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Baculo_PEP_C PF04513.7 EWC46775.1 - 0.15 11.8 1.7 1.1 9.0 1.4 2.0 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Myosin_tail_1 PF01576.14 EWC46775.1 - 0.24 9.1 2.9 0.36 8.4 2.0 1.1 1 0 0 1 1 1 0 Myosin tail Reo_sigmaC PF04582.7 EWC46777.1 - 1.6e-10 40.7 75.0 0.0046 16.1 10.7 7.3 1 1 6 7 7 7 7 Reovirus sigma C capsid protein AAA_13 PF13166.1 EWC46777.1 - 2.5e-05 22.9 20.4 2.5e-05 22.9 14.1 7.9 4 1 3 8 8 8 3 AAA domain APG6 PF04111.7 EWC46777.1 - 0.00016 20.8 10.2 0.00016 20.8 7.1 11.0 5 1 6 11 11 11 2 Autophagy protein Apg6 IncA PF04156.9 EWC46777.1 - 0.00066 19.3 15.2 0.00066 19.3 10.5 11.3 4 2 6 10 10 10 5 IncA protein Spc7 PF08317.6 EWC46777.1 - 0.00069 18.3 4.2 0.00069 18.3 2.9 9.9 3 1 7 10 10 10 4 Spc7 kinetochore protein DUF4201 PF13870.1 EWC46777.1 - 0.0013 18.1 9.0 0.0013 18.1 6.2 10.8 5 2 3 10 10 10 4 Domain of unknown function (DUF4201) CENP-F_leu_zip PF10473.4 EWC46777.1 - 0.0017 18.1 13.8 0.0017 18.1 9.5 12.2 5 1 7 12 12 12 4 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Tropomyosin_1 PF12718.2 EWC46777.1 - 0.0039 17.0 13.7 0.0039 17.0 9.5 13.1 7 1 6 14 14 14 4 Tropomyosin like ATG16 PF08614.6 EWC46777.1 - 0.0059 16.4 9.6 0.0059 16.4 6.7 11.3 4 1 5 10 10 10 3 Autophagy protein 16 (ATG16) DUF427 PF04248.7 EWC46778.1 - 3.1e-19 68.4 0.0 1.6e-14 53.2 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF427) PM0188 PF11477.3 EWC46778.1 - 0.14 10.9 0.1 0.22 10.3 0.1 1.2 1 0 0 1 1 1 0 Sialyltransferase PMO188 DUF2235 PF09994.4 EWC46779.1 - 1.3e-90 303.5 0.0 1.8e-90 303.1 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) Abhydrolase_5 PF12695.2 EWC46779.1 - 0.019 14.7 0.0 0.027 14.2 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Lipase_GDSL_2 PF13472.1 EWC46780.1 - 1.7e-13 51.0 0.1 2.8e-13 50.3 0.0 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.17 EWC46780.1 - 2e-09 37.6 2.2 1e-08 35.2 1.5 2.0 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_3 PF14606.1 EWC46780.1 - 2.4e-06 27.4 0.0 3.5e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Pkr1 PF08636.5 EWC46782.1 - 6e-26 90.3 1.6 8.8e-26 89.7 1.1 1.2 1 0 0 1 1 1 1 ER protein Pkr1 DUF3959 PF13105.1 EWC46782.1 - 0.17 11.2 0.1 0.17 11.2 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3959) FAM176 PF14851.1 EWC46782.1 - 0.59 9.8 11.4 0.91 9.1 0.0 2.3 1 1 1 2 2 2 0 FAM176 family Nucleo_P87 PF07267.6 EWC46782.1 - 2.6 6.6 7.4 3.2 6.3 5.1 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Complex1_LYR PF05347.10 EWC46783.1 - 1.5e-08 34.3 0.0 3.8e-08 32.9 0.0 1.7 2 0 0 2 2 2 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 EWC46783.1 - 1.8e-06 28.0 0.0 3.2e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR_2 PF13233.1 EWC46783.1 - 3.8e-06 27.3 0.1 5e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 Complex1_LYR-like LSM PF01423.17 EWC46784.1 - 4.8e-14 51.6 0.3 6.6e-14 51.2 0.2 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.1 EWC46784.1 - 0.0038 17.1 0.1 0.0054 16.6 0.0 1.3 1 0 0 1 1 1 1 Ataxin 2 SM domain DUF3247 PF11607.3 EWC46784.1 - 0.14 12.3 0.0 0.2 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3247) PA14_2 PF10528.4 EWC46787.1 - 3.7e-24 84.8 0.1 8.8e-24 83.6 0.0 1.7 2 0 0 2 2 2 1 GLEYA domain PAN_1 PF00024.21 EWC46787.1 - 2e-14 53.0 7.6 3.5e-07 29.8 0.4 2.5 2 0 0 2 2 2 2 PAN domain PAN_4 PF14295.1 EWC46787.1 - 5.2e-07 29.2 8.7 0.0006 19.4 0.8 2.8 2 0 0 2 2 2 2 PAN domain PA14 PF07691.7 EWC46787.1 - 2.2e-06 27.3 0.1 5.9e-06 25.9 0.0 1.8 1 0 0 1 1 1 1 PA14 domain PAN_3 PF08277.7 EWC46787.1 - 0.00021 20.8 4.6 0.03 13.9 0.2 2.5 2 0 0 2 2 2 2 PAN-like domain MANEC PF07502.9 EWC46787.1 - 1.1 9.3 7.0 0.84 9.6 0.3 2.8 2 0 0 2 2 2 0 MANEC domain NmrA PF05368.8 EWC46788.1 - 6e-22 78.0 0.0 9.6e-22 77.3 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 EWC46788.1 - 3.8e-16 59.6 0.0 5.7e-16 59.0 0.0 1.3 1 0 0 1 1 1 1 NADH(P)-binding Saccharop_dh PF03435.13 EWC46788.1 - 2.4e-07 30.0 0.0 3.1e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase DapB_N PF01113.15 EWC46788.1 - 4.4e-06 26.6 0.1 8.7e-06 25.6 0.0 1.5 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Epimerase PF01370.16 EWC46788.1 - 0.00011 21.7 0.1 0.00017 21.1 0.1 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 EWC46788.1 - 0.00028 19.7 0.1 0.001 17.8 0.1 1.8 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Semialdhyde_dh PF01118.19 EWC46788.1 - 0.00058 20.1 0.1 0.00097 19.4 0.1 1.3 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain F420_oxidored PF03807.12 EWC46788.1 - 0.0011 19.3 0.2 0.002 18.5 0.2 1.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent GFO_IDH_MocA PF01408.17 EWC46788.1 - 0.0013 19.1 0.2 0.0024 18.3 0.1 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold CoA_binding PF02629.14 EWC46788.1 - 0.0032 17.9 1.6 0.0074 16.7 1.1 1.6 1 1 0 1 1 1 1 CoA binding domain TrkA_N PF02254.13 EWC46788.1 - 0.017 15.1 0.1 0.029 14.3 0.1 1.4 1 0 0 1 1 1 0 TrkA-N domain NAD_binding_4 PF07993.7 EWC46788.1 - 0.017 14.0 0.0 0.028 13.3 0.0 1.3 1 0 0 1 1 1 0 Male sterility protein CoA_binding_2 PF13380.1 EWC46788.1 - 0.021 15.0 0.1 0.036 14.2 0.1 1.4 1 0 0 1 1 1 0 CoA binding domain adh_short PF00106.20 EWC46788.1 - 0.039 13.8 1.1 0.076 12.9 0.8 1.5 1 1 0 1 1 1 0 short chain dehydrogenase Zn_clus PF00172.13 EWC46789.1 - 3.6e-07 29.9 25.0 4.1e-06 26.5 4.3 2.2 2 0 0 2 2 2 2 Fungal Zn(2)-Cys(6) binuclear cluster domain AAA_13 PF13166.1 EWC46790.1 - 5.8 5.2 16.1 0.12 10.7 6.0 1.7 2 0 0 2 2 2 0 AAA domain DUF4066 PF13278.1 EWC46791.1 - 8.1e-23 80.5 0.0 4.4e-19 68.3 0.0 2.3 2 0 0 2 2 2 2 Putative amidotransferase DJ-1_PfpI PF01965.19 EWC46791.1 - 7.1e-06 25.5 0.0 3.4e-05 23.3 0.0 2.0 1 1 0 1 1 1 1 DJ-1/PfpI family Glyco_hydro_31 PF01055.21 EWC46792.1 - 2.3e-159 530.9 4.8 2.9e-159 530.6 3.3 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.1 EWC46792.1 - 0.00029 20.6 0.7 0.00029 20.6 0.5 2.9 4 0 0 4 4 4 1 Galactose mutarotase-like zf-C2HC_2 PF13913.1 EWC46794.1 - 0.0012 18.3 0.3 0.0025 17.4 0.2 1.5 1 0 0 1 1 1 1 zinc-finger of a C2HC-type zf-C2H2 PF00096.21 EWC46794.1 - 0.01 16.1 4.6 0.025 14.9 0.4 2.5 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EWC46794.1 - 0.092 13.1 7.6 0.12 12.7 0.1 3.3 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_6 PF13912.1 EWC46794.1 - 1 9.3 7.5 0.13 12.2 0.5 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger zf-H2C2_2 PF13465.1 EWC46794.1 - 3.2 8.1 8.3 0.12 12.7 1.0 2.1 2 0 0 2 2 2 0 Zinc-finger double domain NMO PF03060.10 EWC46796.1 - 1.5e-59 201.8 2.9 8.5e-56 189.4 1.2 2.0 1 1 0 2 2 2 2 Nitronate monooxygenase IMPDH PF00478.20 EWC46796.1 - 4.9e-08 32.2 0.1 2.5e-07 29.9 0.1 1.9 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.13 EWC46796.1 - 0.0014 17.5 2.1 0.0027 16.6 1.4 1.4 1 0 0 1 1 1 1 FMN-dependent dehydrogenase PEP-utilizers PF00391.18 EWC46796.1 - 0.0083 15.6 2.5 0.0093 15.5 0.2 2.2 3 0 0 3 3 3 1 PEP-utilising enzyme, mobile domain FAD_binding_3 PF01494.14 EWC46797.1 - 4.4e-44 150.9 0.0 5.7e-44 150.6 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.19 EWC46797.1 - 2e-06 26.9 0.1 1.8e-05 23.8 0.0 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EWC46797.1 - 4.1e-06 26.7 0.0 1.3e-05 25.1 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.9 EWC46797.1 - 7.8e-06 24.6 0.0 1.1e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_2 PF07992.9 EWC46797.1 - 9.8e-06 25.5 0.1 1.5e-05 24.9 0.1 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 EWC46797.1 - 4e-05 22.6 0.2 6.4e-05 21.9 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.12 EWC46797.1 - 0.00094 18.3 0.1 0.0019 17.3 0.1 1.4 1 0 0 1 1 1 1 Thi4 family Lycopene_cycl PF05834.7 EWC46797.1 - 0.0035 16.3 0.0 0.0062 15.4 0.0 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein GIDA PF01134.17 EWC46797.1 - 0.0038 16.1 0.1 0.0074 15.1 0.1 1.5 1 0 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox_3 PF13738.1 EWC46797.1 - 0.016 15.2 0.0 0.039 14.0 0.0 1.8 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 EWC46797.1 - 0.022 14.5 0.0 0.048 13.4 0.0 1.6 1 0 0 1 1 1 0 FAD-NAD(P)-binding 3HCDH_N PF02737.13 EWC46797.1 - 0.11 12.2 0.0 0.22 11.1 0.0 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Asp PF00026.18 EWC46798.1 - 5.9e-30 104.5 0.0 9.6e-29 100.6 0.0 2.1 1 1 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.1 EWC46798.1 - 0.00011 22.6 0.1 0.024 15.1 0.0 2.8 3 0 0 3 3 3 1 Aspartyl protease gag-asp_proteas PF13975.1 EWC46798.1 - 0.0076 16.0 0.0 0.034 13.9 0.0 2.1 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease RVP PF00077.15 EWC46798.1 - 0.055 13.3 0.1 0.2 11.5 0.0 1.9 2 0 0 2 2 2 0 Retroviral aspartyl protease TAXi_N PF14543.1 EWC46798.1 - 0.11 12.4 0.0 0.47 10.3 0.0 2.0 2 1 0 2 2 2 0 Xylanase inhibitor N-terminal Chromate_transp PF02417.10 EWC46799.1 - 6.1e-52 175.6 38.3 1.2e-27 96.5 9.6 2.3 3 0 0 3 3 3 2 Chromate transporter TPR_11 PF13414.1 EWC46801.1 - 1.8e-22 78.7 4.3 0.0008 19.0 0.2 7.8 6 1 1 7 7 7 5 TPR repeat TPR_1 PF00515.23 EWC46801.1 - 8.7e-13 47.2 12.8 0.042 13.4 0.0 9.8 11 0 0 11 11 11 4 Tetratricopeptide repeat TPR_16 PF13432.1 EWC46801.1 - 2.6e-12 47.0 14.4 0.11 13.2 0.0 7.4 7 1 1 8 8 7 5 Tetratricopeptide repeat TPR_14 PF13428.1 EWC46801.1 - 4.6e-12 45.4 3.4 0.49 11.1 0.0 9.1 7 3 4 11 11 11 2 Tetratricopeptide repeat TPR_2 PF07719.12 EWC46801.1 - 2.8e-11 42.4 14.1 1.6 8.8 0.0 10.6 11 0 0 11 11 11 2 Tetratricopeptide repeat TPR_19 PF14559.1 EWC46801.1 - 4.5e-10 39.7 1.2 0.047 14.0 0.0 8.0 7 2 2 9 9 9 1 Tetratricopeptide repeat Apc3 PF12895.2 EWC46801.1 - 5.7e-09 35.9 7.4 0.0007 19.6 0.0 6.2 6 1 0 6 6 6 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.1 EWC46801.1 - 9.3e-08 31.6 0.3 0.049 13.8 0.0 6.6 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_9 PF13371.1 EWC46801.1 - 1.4e-06 28.0 0.1 0.43 10.4 0.0 5.0 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.1 EWC46801.1 - 2.1e-06 27.0 0.8 0.14 12.0 0.0 7.0 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_12 PF13424.1 EWC46801.1 - 9.1e-05 22.3 18.3 1.4 8.8 0.0 8.3 8 1 1 9 9 8 1 Tetratricopeptide repeat TPR_6 PF13174.1 EWC46801.1 - 0.00096 19.4 14.9 6.3 7.4 0.0 8.6 10 0 0 10 10 9 1 Tetratricopeptide repeat TPR_7 PF13176.1 EWC46801.1 - 0.0012 18.4 3.8 14 5.7 0.0 6.6 6 0 0 6 6 6 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 EWC46801.1 - 0.005 16.6 1.6 18 5.2 0.1 4.0 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat SDA1 PF05285.7 EWC46801.1 - 0.064 12.5 7.7 0.15 11.3 5.4 1.5 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.7 EWC46801.1 - 0.56 8.0 11.4 0.022 12.7 4.0 1.4 2 0 0 2 2 2 0 Nop14-like family Ribosomal_L29e PF01779.12 EWC46802.1 - 6.7e-23 80.2 8.2 9.9e-23 79.7 5.7 1.3 1 0 0 1 1 1 1 Ribosomal L29e protein family Ribosomal_L11_N PF03946.9 EWC46803.1 - 1.4e-17 62.8 0.1 2e-17 62.3 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.14 EWC46803.1 - 3.5e-10 39.8 0.4 6.2e-10 39.0 0.3 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain IF2_N PF04760.10 EWC46803.1 - 0.033 13.8 0.4 0.18 11.4 0.0 2.3 1 1 1 2 2 2 0 Translation initiation factor IF-2, N-terminal region WD40 PF00400.27 EWC46804.1 - 1.3e-10 40.7 1.8 0.066 13.1 0.3 5.7 5 1 0 5 5 5 3 WD domain, G-beta repeat LisH PF08513.6 EWC46804.1 - 6.6e-05 22.5 0.1 0.00012 21.6 0.1 1.5 1 0 0 1 1 1 1 LisH Acetyltransf_1 PF00583.19 EWC46806.1 - 7.7e-13 48.2 0.1 1.2e-12 47.6 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.5 EWC46806.1 - 3.2e-06 26.8 0.1 5.4e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.1 EWC46806.1 - 3.9e-05 23.7 0.2 7.7e-05 22.7 0.0 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 EWC46806.1 - 9.6e-05 22.4 0.0 0.00013 22.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 EWC46806.1 - 0.062 13.1 0.2 0.11 12.4 0.1 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 EWC46806.1 - 0.12 12.2 0.0 0.18 11.6 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain SAM_2 PF07647.12 EWC46807.1 - 9.7e-10 38.1 0.1 1.7e-09 37.4 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.25 EWC46807.1 - 4.4e-07 29.9 0.1 9.5e-07 28.9 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) IGR PF09597.5 EWC46807.1 - 0.038 13.8 0.1 0.097 12.5 0.1 1.7 1 0 0 1 1 1 0 IGR protein motif HET PF06985.6 EWC46808.1 - 9.3e-10 38.8 0.8 4.1e-07 30.2 0.0 2.4 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) Arf PF00025.16 EWC46809.1 - 1.1e-42 145.2 0.0 1.3e-42 145.0 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.17 EWC46809.1 - 3e-19 69.0 0.0 3.5e-19 68.7 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EWC46809.1 - 3.6e-10 40.3 0.0 1.4e-09 38.5 0.0 1.8 2 0 0 2 2 2 1 Miro-like protein SRPRB PF09439.5 EWC46809.1 - 3.9e-08 32.7 0.0 4.3e-08 32.5 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.18 EWC46809.1 - 3.8e-06 26.8 0.0 8.3e-06 25.7 0.0 1.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 EWC46809.1 - 2.2e-05 23.9 0.0 0.00049 19.5 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 EWC46809.1 - 2.4e-05 23.6 0.0 2.8e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.15 EWC46809.1 - 6.5e-05 21.7 0.0 0.00014 20.6 0.0 1.6 1 1 1 2 2 2 1 G-protein alpha subunit Dynamin_N PF00350.18 EWC46809.1 - 0.0082 15.9 0.0 0.1 12.4 0.1 2.1 1 1 1 2 2 2 1 Dynamin family FeoB_N PF02421.13 EWC46809.1 - 0.027 13.7 0.6 0.11 11.7 0.4 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B PduV-EutP PF10662.4 EWC46809.1 - 0.062 12.7 0.2 0.22 10.9 0.0 1.9 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ATP_bind_1 PF03029.12 EWC46809.1 - 0.099 12.1 0.0 0.22 11.0 0.0 1.5 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein Med14 PF08638.6 EWC46810.1 - 8.9e-56 188.2 0.0 2.6e-55 186.6 0.0 1.8 2 0 0 2 2 2 1 Mediator complex subunit MED14 Glyco_hydro_61 PF03443.9 EWC46811.1 - 7.7e-59 199.1 0.0 1.6e-58 198.0 0.0 1.5 2 0 0 2 2 2 1 Glycosyl hydrolase family 61 CBM_1 PF00734.13 EWC46811.1 - 0.00015 21.3 5.1 0.00015 21.3 3.5 2.2 2 0 0 2 2 2 1 Fungal cellulose binding domain ATG22 PF11700.3 EWC46812.1 - 3.9e-180 599.3 12.1 4.5e-180 599.2 8.4 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like MFS_2 PF13347.1 EWC46812.1 - 0.0015 16.9 22.4 0.0027 16.1 4.4 2.6 2 1 0 2 2 2 2 MFS/sugar transport protein DUF2254 PF10011.4 EWC46812.1 - 0.031 12.7 1.8 0.064 11.7 1.3 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2254) Hum_adeno_E3A PF05393.6 EWC46812.1 - 0.23 11.1 2.4 7.2 6.3 0.0 3.2 3 0 0 3 3 3 0 Human adenovirus early E3A glycoprotein F-box-like PF12937.2 EWC46813.1 - 1.8e-08 33.9 1.3 3.8e-08 32.9 0.9 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EWC46813.1 - 0.00019 20.9 0.7 0.00039 19.9 0.5 1.5 1 0 0 1 1 1 1 F-box domain MIT PF04212.13 EWC46813.1 - 0.14 12.0 0.1 0.29 11.0 0.1 1.5 1 0 0 1 1 1 0 MIT (microtubule interacting and transport) domain PXA PF02194.10 EWC46814.1 - 7.8e-26 90.7 3.2 1.1e-25 90.2 0.5 2.1 2 0 0 2 2 2 1 PXA domain Nexin_C PF08628.7 EWC46814.1 - 2.2e-16 59.9 2.2 3.1e-16 59.4 0.3 2.2 2 0 0 2 2 2 1 Sorting nexin C terminal PX PF00787.19 EWC46814.1 - 0.0096 15.7 0.0 0.024 14.4 0.0 1.7 1 0 0 1 1 1 1 PX domain eIF-3c_N PF05470.7 EWC46815.1 - 0.038 12.0 0.0 0.042 11.9 0.0 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Tetraspannin PF00335.15 EWC46816.1 - 2.5e-05 23.6 10.7 3.6e-05 23.1 7.4 1.2 1 0 0 1 1 1 1 Tetraspanin family SPC25 PF06703.6 EWC46816.1 - 0.0012 18.4 0.7 0.0042 16.6 0.1 2.0 1 1 1 2 2 2 1 Microsomal signal peptidase 25 kDa subunit (SPC25) DUF4191 PF13829.1 EWC46816.1 - 1.5 7.9 8.1 2.7 7.0 0.9 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4191) TPP_enzyme_N PF02776.13 EWC46817.1 - 6.4e-32 110.4 0.0 9.5e-32 109.8 0.0 1.3 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.17 EWC46817.1 - 1.2e-28 99.6 0.0 2.5e-28 98.5 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.16 EWC46817.1 - 2.5e-19 69.3 0.0 5.8e-19 68.1 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DXP_synthase_N PF13292.1 EWC46817.1 - 0.0024 16.8 0.0 0.004 16.1 0.0 1.3 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase ATP12 PF07542.6 EWC46818.1 - 0.0071 16.2 0.0 0.01 15.7 0.0 1.3 1 0 0 1 1 1 1 ATP12 chaperone protein ATP12 PF07542.6 EWC46819.1 - 2.2e-21 76.0 0.0 3e-21 75.6 0.0 1.1 1 0 0 1 1 1 1 ATP12 chaperone protein zf-C3HC PF07967.8 EWC46820.1 - 3.5e-39 133.6 0.3 1.3e-30 105.8 0.0 2.2 2 0 0 2 2 2 2 C3HC zinc finger-like Rsm1 PF08600.5 EWC46820.1 - 4e-22 77.8 0.1 4e-22 77.8 0.1 2.6 3 0 0 3 3 3 1 Rsm1-like BIR PF00653.16 EWC46820.1 - 0.014 15.7 0.8 0.62 10.5 0.1 2.8 2 1 0 2 2 2 0 Inhibitor of Apoptosis domain DMPK_coil PF08826.5 EWC46820.1 - 0.086 12.7 0.1 0.16 11.8 0.1 1.4 1 0 0 1 1 1 0 DMPK coiled coil domain like E1_dh PF00676.15 EWC46821.1 - 3.2e-93 311.7 0.1 4.4e-93 311.2 0.1 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.1 EWC46821.1 - 0.044 12.6 0.0 0.22 10.4 0.0 1.9 1 1 0 2 2 2 0 1-deoxy-D-xylulose-5-phosphate synthase PAT1 PF09770.4 EWC46822.1 - 0.44 8.7 9.3 0.56 8.3 6.5 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 KH_1 PF00013.24 EWC46823.1 - 0.0026 17.3 0.0 0.0079 15.8 0.0 1.8 1 0 0 1 1 1 1 KH domain KH_3 PF13014.1 EWC46823.1 - 0.0038 16.8 0.0 0.01 15.4 0.0 1.7 1 0 0 1 1 1 1 KH domain CT47 PF15623.1 EWC46823.1 - 0.32 10.6 15.1 0.42 10.2 10.5 1.1 1 0 0 1 1 1 0 Cancer/testis gene family 47 Proteasome PF00227.21 EWC46824.1 - 3.5e-58 196.0 0.2 4.1e-58 195.7 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 EWC46824.1 - 2.1e-14 52.4 0.1 6.9e-14 50.8 0.1 1.9 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature Nitrate_red_gam PF02665.9 EWC46824.1 - 0.057 12.7 0.0 0.083 12.2 0.0 1.2 1 0 0 1 1 1 0 Nitrate reductase gamma subunit ODV-E18 PF10717.4 EWC46825.1 - 0.032 13.6 2.9 0.046 13.1 2.0 1.4 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 ATP-synt_8 PF00895.15 EWC46825.1 - 0.045 13.9 3.5 0.045 13.9 2.4 1.8 2 0 0 2 2 2 0 ATP synthase protein 8 Tic20 PF09685.5 EWC46825.1 - 2.8 7.9 9.0 3.8 7.5 6.2 1.2 1 0 0 1 1 1 0 Tic20-like protein Ubie_methyltran PF01209.13 EWC46827.1 - 7e-85 283.8 0.1 9e-85 283.4 0.1 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.1 EWC46827.1 - 5.3e-14 52.0 0.0 1.2e-13 50.9 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 EWC46827.1 - 7.3e-12 45.6 0.0 1.2e-11 44.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EWC46827.1 - 2.7e-09 36.9 0.0 4.1e-09 36.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EWC46827.1 - 4e-08 33.5 0.0 2.4e-07 31.0 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 EWC46827.1 - 5.4e-07 30.0 0.0 1.5e-06 28.6 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 EWC46827.1 - 1.6e-06 28.6 0.0 3.4e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EWC46827.1 - 0.00047 20.1 0.0 0.001 19.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain DREV PF05219.7 EWC46827.1 - 0.014 14.2 0.0 0.022 13.6 0.0 1.3 1 0 0 1 1 1 0 DREV methyltransferase Methyltransf_32 PF13679.1 EWC46827.1 - 0.017 14.8 0.0 0.029 14.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain WW PF00397.21 EWC46828.1 - 1.3e-11 44.1 6.2 1.5e-07 31.1 1.2 3.2 2 0 0 2 2 2 2 WW domain FF PF01846.14 EWC46828.1 - 3.9e-11 42.7 5.4 1.1e-09 38.0 0.0 3.6 3 0 0 3 3 3 2 FF domain DUF2462 PF09495.5 EWC46829.1 - 3.3e-18 66.2 8.4 3.3e-18 66.2 5.8 1.8 1 1 1 2 2 2 1 Protein of unknown function (DUF2462) Aminotran_1_2 PF00155.16 EWC46830.1 - 2.1e-11 43.3 0.0 2.7e-11 43.0 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.2 EWC46830.1 - 0.0011 17.6 0.0 0.0047 15.5 0.0 1.9 2 0 0 2 2 2 1 Alanine-glyoxylate amino-transferase HhH-GPD PF00730.20 EWC46831.1 - 1.7e-07 31.5 0.0 2.9e-07 30.7 0.0 1.3 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein Peptidase_M3 PF01432.15 EWC46832.1 - 2.1e-92 310.5 0.0 2.5e-92 310.3 0.0 1.0 1 0 0 1 1 1 1 Peptidase family M3 Peptidase_M50B PF13398.1 EWC46832.1 - 0.036 13.4 1.5 0.07 12.4 1.0 1.4 1 0 0 1 1 1 0 Peptidase M50B-like AA_kinase PF00696.23 EWC46833.1 - 6e-42 143.8 0.0 1e-41 143.1 0.0 1.4 1 0 0 1 1 1 1 Amino acid kinase family ACT PF01842.20 EWC46833.1 - 1.9e-12 46.4 0.3 2.2e-08 33.4 0.1 2.6 2 0 0 2 2 2 2 ACT domain ACT_7 PF13840.1 EWC46833.1 - 7.5e-09 34.9 4.5 2.8e-08 33.1 0.2 3.1 3 0 0 3 3 3 1 ACT domain DUF1604 PF07713.8 EWC46834.1 - 7.4e-37 125.0 0.6 7.4e-37 125.0 0.4 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1604) G-patch PF01585.18 EWC46834.1 - 1.4e-06 27.9 1.7 1.4e-06 27.9 1.2 2.1 2 0 0 2 2 2 1 G-patch domain G-patch_2 PF12656.2 EWC46834.1 - 4.9e-05 23.0 2.2 0.007 16.1 0.4 3.2 1 1 1 2 2 2 2 DExH-box splicing factor binding site Ku PF02735.11 EWC46835.1 - 1.9e-39 135.1 0.0 2.9e-39 134.5 0.0 1.2 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.10 EWC46835.1 - 1.5e-26 93.2 0.0 2.3e-26 92.6 0.0 1.3 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain Ku_C PF03730.9 EWC46835.1 - 8.2e-13 48.7 1.4 1.8e-11 44.4 0.0 2.9 3 0 0 3 3 3 1 Ku70/Ku80 C-terminal arm SAP PF02037.22 EWC46835.1 - 1e-10 40.8 0.0 1.9e-10 40.0 0.0 1.5 1 0 0 1 1 1 1 SAP domain VWA_2 PF13519.1 EWC46835.1 - 0.036 14.1 0.3 0.35 10.9 0.0 2.4 1 1 1 2 2 2 0 von Willebrand factor type A domain HeH PF12949.2 EWC46835.1 - 0.041 13.4 0.0 0.09 12.3 0.0 1.6 1 0 0 1 1 1 0 HeH/LEM domain VWA PF00092.23 EWC46835.1 - 0.12 12.1 0.0 0.63 9.7 0.0 2.1 1 1 0 1 1 1 0 von Willebrand factor type A domain PX PF00787.19 EWC46836.1 - 1e-18 67.1 0.3 3.4e-18 65.4 0.2 1.9 1 0 0 1 1 1 1 PX domain Vps5 PF09325.5 EWC46836.1 - 1.2e-07 31.2 8.7 0.00083 18.6 2.4 2.1 2 0 0 2 2 2 2 Vps5 C terminal like BAR PF03114.13 EWC46836.1 - 5.1e-05 22.8 5.3 0.0037 16.8 3.9 2.9 2 1 0 2 2 2 1 BAR domain Actin PF00022.14 EWC46837.1 - 1.1e-35 122.8 0.0 5.1e-34 117.3 0.0 2.5 2 1 0 2 2 2 2 Actin NTR2 PF15458.1 EWC46837.1 - 0.7 9.0 6.2 0.056 12.6 0.4 1.8 2 0 0 2 2 2 0 Nineteen complex-related protein 2 Lyase_1 PF00206.15 EWC46838.1 - 6.9e-97 324.3 0.0 2.8e-96 322.4 0.0 1.7 2 0 0 2 2 2 1 Lyase ASL_C2 PF14698.1 EWC46838.1 - 4.7e-25 87.4 0.0 1e-24 86.3 0.0 1.6 1 0 0 1 1 1 1 Argininosuccinate lyase C-terminal FKBP_C PF00254.23 EWC46839.1 - 4.6e-29 100.2 0.0 5.4e-29 100.0 0.0 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Arf PF00025.16 EWC46840.1 - 4.5e-42 143.2 0.0 5.9e-42 142.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.17 EWC46840.1 - 1.5e-14 53.6 0.0 2.3e-14 53.0 0.0 1.3 1 0 0 1 1 1 1 Ras family SRPRB PF09439.5 EWC46840.1 - 6.5e-11 41.7 0.0 1.8e-10 40.3 0.0 1.6 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.15 EWC46840.1 - 1e-10 40.9 0.1 0.0001 21.1 0.0 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Miro PF08477.8 EWC46840.1 - 4.8e-10 39.9 0.0 6.9e-10 39.4 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Gtr1_RagA PF04670.7 EWC46840.1 - 6.7e-09 35.2 0.0 9.6e-09 34.7 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 EWC46840.1 - 6.8e-07 28.8 0.0 6e-05 22.5 0.0 2.1 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 EWC46840.1 - 2e-05 24.5 0.0 4.1e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.1 EWC46840.1 - 0.00092 19.3 0.0 0.0066 16.5 0.0 2.2 1 1 1 2 2 2 1 AAA domain PduV-EutP PF10662.4 EWC46840.1 - 0.11 11.9 0.0 1.1 8.6 0.0 2.4 2 1 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.1 EWC46840.1 - 0.13 12.1 0.0 0.36 10.7 0.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain Pneumo_phosprot PF02478.11 EWC46841.1 - 0.14 11.7 3.7 0.25 10.8 2.6 1.3 1 0 0 1 1 1 0 Pneumovirus phosphoprotein MIP-T3 PF10243.4 EWC46843.1 - 4.8 5.5 38.8 8.4 4.7 26.9 1.4 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 ApbA_C PF08546.6 EWC46844.1 - 5.2e-33 113.6 0.2 8.9e-33 112.9 0.1 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.11 EWC46844.1 - 2.5e-28 98.4 0.0 3.4e-28 97.9 0.0 1.2 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA TrkA_N PF02254.13 EWC46844.1 - 0.12 12.3 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain Sas10_Utp3 PF04000.10 EWC46845.1 - 3.9e-18 65.4 1.5 8.4e-18 64.3 1.0 1.6 1 0 0 1 1 1 1 Sas10/Utp3/C1D family Aminotran_1_2 PF00155.16 EWC46846.1 - 5.2e-81 272.4 0.0 5.8e-81 272.2 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II FAM176 PF14851.1 EWC46847.1 - 2.9 7.5 5.2 21 4.7 3.6 2.4 1 1 0 1 1 1 0 FAM176 family LtrA PF06772.6 EWC46848.1 - 5.5e-22 78.1 15.4 5.5e-22 78.1 10.7 1.5 2 0 0 2 2 2 1 Bacterial low temperature requirement A protein (LtrA) T_cell_tran_alt PF15128.1 EWC46848.1 - 0.24 10.8 1.7 12 5.4 0.2 2.9 2 1 0 2 2 2 0 T-cell leukemia translocation-altered Vma12 PF11712.3 EWC46848.1 - 5 6.8 6.1 3.5 7.3 1.6 2.4 2 0 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase TP6A_N PF04406.9 EWC46850.1 - 2.2e-09 36.8 0.0 4.4e-09 35.8 0.0 1.5 1 0 0 1 1 1 1 Type IIB DNA topoisomerase Hirudin PF00713.12 EWC46850.1 - 0.022 14.8 0.4 0.064 13.3 0.3 1.7 1 0 0 1 1 1 0 Hirudin Exo5 PF09810.4 EWC46851.1 - 8.7e-83 278.1 0.1 3.9e-82 276.0 0.0 1.9 2 0 0 2 2 2 1 Exonuclease V - a 5' deoxyribonuclease PDDEXK_1 PF12705.2 EWC46851.1 - 0.00038 19.9 5.5 0.57 9.5 0.1 3.8 3 1 0 3 3 3 2 PD-(D/E)XK nuclease superfamily Glyco_transf_21 PF13506.1 EWC46852.1 - 8e-18 64.3 0.0 1.3e-09 37.5 0.0 3.2 3 0 0 3 3 3 2 Glycosyl transferase family 21 Glyco_tranf_2_3 PF13641.1 EWC46852.1 - 1.3e-13 51.2 0.0 3.2e-13 50.0 0.0 1.6 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.21 EWC46852.1 - 1.5e-05 24.7 0.0 2.6e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_trans_2_3 PF13632.1 EWC46852.1 - 0.0014 18.3 0.2 0.0032 17.1 0.2 1.6 1 0 0 1 1 1 1 Glycosyl transferase family group 2 His_Phos_1 PF00300.17 EWC46853.1 - 2.2e-29 102.5 0.5 5.4e-29 101.3 0.0 1.8 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) DUF1153 PF06627.6 EWC46853.1 - 0.0022 17.7 0.0 0.0051 16.6 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1153) His_Phos_2 PF00328.17 EWC46853.1 - 0.023 14.0 0.0 0.023 14.0 0.0 2.0 2 1 0 2 2 2 0 Histidine phosphatase superfamily (branch 2) UPF0547 PF10571.4 EWC46853.1 - 0.075 12.7 0.1 0.25 11.0 0.1 1.8 1 0 0 1 1 1 0 Uncharacterised protein family UPF0547 Glyco_transf_90 PF05686.7 EWC46854.1 - 2e-12 46.5 7.4 5.3e-10 38.5 2.5 3.1 2 2 0 2 2 2 2 Glycosyl transferase family 90 LRR_6 PF13516.1 EWC46855.1 - 5e-08 32.2 2.3 0.23 11.6 0.0 5.9 7 0 0 7 7 7 3 Leucine Rich repeat LRR_4 PF12799.2 EWC46855.1 - 7.7e-08 31.7 0.1 0.0016 17.9 0.0 3.0 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 EWC46855.1 - 1.3e-05 24.6 1.3 1.8 8.9 0.0 5.1 5 0 0 5 5 5 2 Leucine Rich Repeat LRR_8 PF13855.1 EWC46855.1 - 2.8e-05 23.7 0.3 0.00026 20.6 0.1 2.6 1 1 0 1 1 1 1 Leucine rich repeat LRR_7 PF13504.1 EWC46855.1 - 0.0002 21.0 0.8 3 8.4 0.0 4.3 3 0 0 3 3 3 2 Leucine rich repeat Methyltransf_28 PF02636.12 EWC46856.1 - 2.5e-73 246.5 0.0 3.1e-73 246.2 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase ACBP PF00887.14 EWC46857.1 - 5.5e-29 99.6 0.0 9.2e-29 98.9 0.0 1.4 1 0 0 1 1 1 1 Acyl CoA binding protein Paf1 PF03985.8 EWC46858.1 - 3.4e-46 157.8 0.0 4.1e-46 157.6 0.0 1.0 1 0 0 1 1 1 1 Paf1 Bet_v_1 PF00407.14 EWC46858.1 - 0.14 11.7 0.0 0.24 11.0 0.0 1.3 1 0 0 1 1 1 0 Pathogenesis-related protein Bet v I family Coatomer_E PF04733.9 EWC46859.1 - 7.4e-63 212.4 5.1 8.5e-63 212.2 3.5 1.0 1 0 0 1 1 1 1 Coatomer epsilon subunit TPR_16 PF13432.1 EWC46859.1 - 2.1e-07 31.4 3.3 0.0072 16.9 0.0 4.2 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.1 EWC46859.1 - 9.5e-06 25.1 0.0 0.33 10.6 0.0 3.5 3 1 0 3 3 3 2 TPR repeat TPR_2 PF07719.12 EWC46859.1 - 1.7e-05 24.3 2.3 0.11 12.4 0.0 4.5 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_14 PF13428.1 EWC46859.1 - 1.9e-05 24.8 10.6 0.036 14.6 0.1 5.3 3 1 3 6 6 5 2 Tetratricopeptide repeat TPR_1 PF00515.23 EWC46859.1 - 2e-05 23.9 0.1 0.32 10.6 0.0 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.1 EWC46859.1 - 3e-05 24.2 9.6 0.11 12.8 0.3 4.1 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.1 EWC46859.1 - 0.0017 18.1 1.3 2.6 7.9 0.0 3.4 2 1 1 3 3 3 2 Tetratricopeptide repeat Apc3 PF12895.2 EWC46859.1 - 0.0033 17.5 0.0 1.3 9.1 0.0 3.2 2 1 1 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.1 EWC46859.1 - 0.0039 16.8 0.1 3.5 7.6 0.0 3.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.1 EWC46859.1 - 0.0043 16.9 2.0 3.7 7.5 0.1 3.8 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_4 PF07721.9 EWC46859.1 - 0.0071 16.6 4.6 4.1 8.1 0.0 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.1 EWC46859.1 - 0.013 15.3 0.2 9.1 6.3 0.0 3.5 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_17 PF13431.1 EWC46859.1 - 0.027 14.6 0.0 27 5.2 0.0 3.5 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_6 PF13174.1 EWC46859.1 - 0.034 14.5 0.2 1.2e+02 3.4 0.0 4.6 4 1 0 4 4 4 0 Tetratricopeptide repeat MYCBPAP PF14646.1 EWC46859.1 - 0.078 11.6 0.3 0.15 10.7 0.1 1.5 2 0 0 2 2 2 0 MYCBP-associated protein family TPR_20 PF14561.1 EWC46859.1 - 1.3 9.1 5.9 1.3 9.1 0.0 3.1 3 2 0 3 3 3 0 Tetratricopeptide repeat Spc97_Spc98 PF04130.8 EWC46860.1 - 3.4e-71 240.2 0.0 5.6e-71 239.4 0.0 1.4 1 1 0 1 1 1 1 Spc97 / Spc98 family TRAP_alpha PF03896.11 EWC46860.1 - 0.036 13.0 8.3 0.061 12.3 5.7 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Daxx PF03344.10 EWC46860.1 - 0.041 12.3 18.0 0.073 11.5 12.5 1.3 1 0 0 1 1 1 0 Daxx Family CENP-B_dimeris PF09026.5 EWC46860.1 - 0.12 12.6 24.1 0.48 10.6 15.7 2.6 2 0 0 2 2 2 0 Centromere protein B dimerisation domain RXT2_N PF08595.6 EWC46860.1 - 0.28 10.9 10.2 1.1 9.0 6.4 2.4 2 0 0 2 2 2 0 RXT2-like, N-terminal Sigma70_ner PF04546.8 EWC46860.1 - 0.41 10.2 14.4 0.48 10.0 8.2 2.4 2 0 0 2 2 2 0 Sigma-70, non-essential region CDC45 PF02724.9 EWC46860.1 - 0.72 7.8 17.1 0.14 10.1 9.1 1.7 2 0 0 2 2 2 0 CDC45-like protein Nop14 PF04147.7 EWC46860.1 - 3.5 5.4 25.3 7.8 4.2 17.5 1.5 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.7 EWC46860.1 - 4.1 6.6 22.5 0.73 9.0 12.1 2.0 2 0 0 2 2 2 0 SDA1 Paf1 PF03985.8 EWC46860.1 - 4.6 5.8 15.6 8.6 4.9 10.8 1.4 1 0 0 1 1 1 0 Paf1 BUD22 PF09073.5 EWC46860.1 - 6.2 5.7 19.1 0.016 14.3 6.4 1.7 2 0 0 2 2 1 0 BUD22 TCO89 PF10452.4 EWC46861.1 - 3.1e-07 29.6 10.2 3.2e-06 26.3 0.0 3.2 3 0 0 3 3 3 2 TORC1 subunit TCO89 CarboxypepD_reg PF13620.1 EWC46862.1 - 0.011 15.8 0.0 0.038 14.0 0.0 2.0 1 0 0 1 1 1 0 Carboxypeptidase regulatory-like domain DSHCT PF08148.7 EWC46862.1 - 0.065 12.4 0.2 0.27 10.4 0.0 2.1 2 0 0 2 2 2 0 DSHCT (NUC185) domain UCH_1 PF13423.1 EWC46864.1 - 1.4e-57 195.3 0.4 2.6e-57 194.5 0.3 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RNase_T PF00929.19 EWC46864.1 - 4.2e-28 98.6 0.0 7.5e-28 97.8 0.0 1.4 1 0 0 1 1 1 1 Exonuclease Rad4 PF03835.10 EWC46866.1 - 1.2e-28 99.3 0.1 3.9e-28 97.6 0.1 1.9 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain BHD_3 PF10405.4 EWC46866.1 - 1.2e-20 73.0 0.0 2.1e-20 72.1 0.0 1.5 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BHD_1 PF10403.4 EWC46866.1 - 4e-18 64.6 0.0 7.3e-18 63.8 0.0 1.5 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 BHD_2 PF10404.4 EWC46866.1 - 7.6e-13 48.5 0.5 7.6e-13 48.5 0.3 2.6 2 0 0 2 2 2 1 Rad4 beta-hairpin domain 2 Transglut_core PF01841.14 EWC46866.1 - 0.087 13.0 0.1 0.5 10.6 0.0 2.4 1 1 0 1 1 1 0 Transglutaminase-like superfamily Tht1 PF04163.7 EWC46867.1 - 3.6e-16 58.6 2.6 4.9e-16 58.2 1.8 1.2 1 0 0 1 1 1 1 Tht1-like nuclear fusion protein DUF1529 PF07485.6 EWC46867.1 - 0.083 12.6 0.0 0.23 11.1 0.0 1.8 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1259) Band_7 PF01145.20 EWC46868.1 - 2.7e-24 86.0 1.6 4.2e-24 85.4 1.1 1.3 1 0 0 1 1 1 1 SPFH domain / Band 7 family E_Pc_C PF06752.7 EWC46868.1 - 0.026 14.0 0.1 0.035 13.6 0.0 1.2 1 0 0 1 1 1 0 Enhancer of Polycomb C-terminus IBR PF01485.16 EWC46869.1 - 5.2e-18 64.6 31.4 4.9e-11 42.3 2.7 3.6 3 0 0 3 3 3 2 IBR domain RWD PF05773.17 EWC46869.1 - 7.6e-13 48.3 0.0 3.4e-12 46.2 0.0 1.9 2 0 0 2 2 2 1 RWD domain zf-C3HC4_2 PF13923.1 EWC46869.1 - 5.6e-06 26.2 5.7 5.6e-06 26.2 3.9 3.9 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EWC46869.1 - 8.5e-05 22.1 4.5 8.5e-05 22.1 3.1 3.9 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EWC46869.1 - 0.00014 21.6 6.9 0.00014 21.6 4.8 3.7 2 1 1 3 3 3 1 Ring finger domain zf-RING_5 PF14634.1 EWC46869.1 - 0.0055 16.4 7.3 0.0055 16.4 5.1 3.8 2 1 1 3 3 3 1 zinc-RING finger domain Gly_transf_sug PF04488.10 EWC46870.1 - 9.2e-08 32.4 0.2 2.5e-07 31.0 0.1 1.8 1 1 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif TcdA_TcdB PF12919.2 EWC46870.1 - 0.01 14.3 1.5 1.3 7.4 0.0 2.7 3 0 0 3 3 3 0 TcdA/TcdB catalytic glycosyltransferase domain Complex1_30kDa PF00329.14 EWC46871.1 - 9.6e-36 122.1 0.1 1.5e-35 121.5 0.0 1.3 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit zf-RING_4 PF14570.1 EWC46872.1 - 6.3e-19 67.3 13.0 1.1e-18 66.4 9.0 1.4 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain RRM_1 PF00076.17 EWC46872.1 - 8.4e-09 34.9 0.0 6e-08 32.2 0.0 2.5 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EWC46872.1 - 1.1e-05 25.1 0.3 3.3e-05 23.6 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C3HC4_3 PF13920.1 EWC46872.1 - 4.2e-05 23.1 7.2 7.9e-05 22.2 5.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Baculo_IE-1 PF05290.6 EWC46872.1 - 0.00022 20.9 5.0 0.0004 20.1 3.5 1.4 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) RRM_6 PF14259.1 EWC46872.1 - 0.0033 17.3 0.0 0.01 15.7 0.0 2.0 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) zf-UDP PF14569.1 EWC46872.1 - 0.0035 17.0 4.6 0.011 15.5 3.2 1.8 1 0 0 1 1 1 1 Zinc-binding RING-finger zf-C3HC4 PF00097.20 EWC46872.1 - 0.015 14.9 11.3 0.032 13.8 7.8 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) SET_assoc PF11767.3 EWC46872.1 - 0.043 13.1 0.0 0.095 12.0 0.0 1.5 1 0 0 1 1 1 0 Histone lysine methyltransferase SET associated zf-C3HC4_2 PF13923.1 EWC46872.1 - 0.41 10.7 11.6 0.77 9.8 8.0 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF3129 PF11327.3 EWC46874.1 - 3.4e-21 75.8 0.0 7.4e-20 71.5 0.0 2.6 1 1 0 1 1 1 1 Protein of unknown function (DUF3129) Cwf_Cwc_15 PF04889.7 EWC46874.1 - 0.29 10.7 23.2 0.51 10.0 16.1 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF2076 PF09849.4 EWC46874.1 - 0.3 11.1 14.1 0.54 10.2 9.7 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) RNA_pol_3_Rpc31 PF11705.3 EWC46874.1 - 0.46 10.3 22.8 0.78 9.6 15.8 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 DUF1754 PF08555.5 EWC46874.1 - 0.49 11.0 16.6 1.1 9.9 11.5 1.6 1 0 0 1 1 1 0 Eukaryotic family of unknown function (DUF1754) CDC45 PF02724.9 EWC46874.1 - 0.69 7.8 13.1 0.85 7.5 9.1 1.1 1 0 0 1 1 1 0 CDC45-like protein FLO_LFY PF01698.11 EWC46874.1 - 2.1 7.0 10.1 3.2 6.4 7.0 1.2 1 0 0 1 1 1 0 Floricaula / Leafy protein TFIIF_alpha PF05793.7 EWC46874.1 - 7.3 4.8 29.4 11 4.2 20.4 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) COesterase PF00135.23 EWC46875.1 - 9.8e-80 268.7 0.0 1.2e-79 268.4 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 EWC46875.1 - 8e-05 22.3 0.2 0.00025 20.6 0.1 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold DUF2424 PF10340.4 EWC46875.1 - 0.23 10.0 0.2 0.61 8.6 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2424) Nup160 PF11715.3 EWC46876.1 - 6.8e-05 21.2 0.1 0.00022 19.5 0.0 1.8 2 0 0 2 2 2 1 Nucleoporin Nup120/160 Gly_rich_SFCGS PF14272.1 EWC46876.1 - 0.034 14.0 0.2 0.096 12.5 0.1 1.7 1 0 0 1 1 1 0 Glycine-rich SFCGS FtsJ PF01728.14 EWC46877.1 - 8.4e-67 224.6 0.0 1e-66 224.3 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase ATG13 PF10033.4 EWC46878.1 - 3.5e-64 216.4 0.0 4.9e-64 215.9 0.0 1.2 1 0 0 1 1 1 1 Autophagy-related protein 13 Beta-lactamase PF00144.19 EWC46879.1 - 0.1 11.6 0.2 0.14 11.1 0.1 1.2 1 0 0 1 1 1 0 Beta-lactamase Filament PF00038.16 EWC46880.1 - 3.8e-10 39.7 123.6 0.00053 19.5 22.8 5.2 1 1 2 4 4 4 4 Intermediate filament protein TMF_TATA_bd PF12325.3 EWC46880.1 - 0.0012 18.6 6.8 0.0012 18.6 4.7 9.7 4 2 6 10 10 10 2 TATA element modulatory factor 1 TATA binding CENP-F_leu_zip PF10473.4 EWC46880.1 - 0.0027 17.5 19.4 0.0027 17.5 13.4 9.1 1 1 6 9 9 9 6 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Reo_sigmaC PF04582.7 EWC46880.1 - 0.029 13.5 66.0 0.3 10.2 4.3 7.1 1 1 6 8 8 8 0 Reovirus sigma C capsid protein Myosin_tail_1 PF01576.14 EWC46880.1 - 0.035 11.8 148.8 0.013 13.2 18.4 4.1 1 1 2 3 3 3 0 Myosin tail AAA_13 PF13166.1 EWC46880.1 - 2.8 6.2 117.1 0.27 9.6 16.6 4.7 1 1 4 5 5 5 0 AAA domain BUD22 PF09073.5 EWC46881.1 - 6.3e-63 213.3 8.0 6.3e-63 213.3 5.6 2.4 2 1 1 3 3 3 2 BUD22 SIR2 PF02146.12 EWC46882.1 - 3.1e-39 134.5 0.0 4.9e-39 133.8 0.0 1.3 1 1 0 1 1 1 1 Sir2 family Pyridox_ox_2 PF12900.2 EWC46883.1 - 2.8e-35 121.2 0.0 3.7e-35 120.8 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase ABC2_membrane PF01061.19 EWC46884.1 - 2.1e-90 301.5 56.5 4e-47 160.1 9.8 2.7 3 0 0 3 3 2 2 ABC-2 type transporter ABC_tran PF00005.22 EWC46884.1 - 5.5e-33 114.1 0.0 1.1e-16 61.3 0.0 2.4 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.7 EWC46884.1 - 1.4e-29 101.7 0.0 4.7e-26 90.4 0.0 2.9 2 0 0 2 2 2 2 CDR ABC transporter AAA_25 PF13481.1 EWC46884.1 - 2.3e-07 30.4 0.2 0.00049 19.5 0.1 2.6 3 0 0 3 3 2 2 AAA domain DUF258 PF03193.11 EWC46884.1 - 2.4e-06 26.8 0.0 6.8e-05 22.1 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function, DUF258 ABC_trans_N PF14510.1 EWC46884.1 - 3e-06 27.2 0.0 9.6e-06 25.6 0.0 1.9 1 0 0 1 1 1 1 ABC-transporter extracellular N-terminal AAA_22 PF13401.1 EWC46884.1 - 3e-06 27.3 0.2 0.065 13.3 0.1 3.8 3 1 0 3 3 3 2 AAA domain ABC2_membrane_3 PF12698.2 EWC46884.1 - 5.2e-06 25.7 35.6 0.0003 19.9 10.1 2.4 2 0 0 2 2 2 2 ABC-2 family transporter protein AAA_29 PF13555.1 EWC46884.1 - 8.5e-06 25.2 0.7 0.0016 17.9 0.2 2.7 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_16 PF13191.1 EWC46884.1 - 1.2e-05 25.3 0.2 0.00065 19.7 0.0 2.8 3 0 0 3 3 2 1 AAA ATPase domain AAA_17 PF13207.1 EWC46884.1 - 1.3e-05 25.9 0.0 0.0068 17.2 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.1 EWC46884.1 - 1.8e-05 24.6 0.0 0.038 13.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_21 PF13304.1 EWC46884.1 - 3.4e-05 23.9 0.0 0.091 12.7 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.1 EWC46884.1 - 8e-05 22.9 0.0 0.041 14.1 0.0 2.7 2 0 0 2 2 2 1 AAA domain FtsK_SpoIIIE PF01580.13 EWC46884.1 - 0.00023 20.7 0.0 0.58 9.5 0.0 2.4 2 0 0 2 2 2 2 FtsK/SpoIIIE family Arch_ATPase PF01637.13 EWC46884.1 - 0.00027 20.7 0.0 1.3 8.7 0.0 3.2 3 0 0 3 3 3 2 Archaeal ATPase RNA_helicase PF00910.17 EWC46884.1 - 0.00045 20.3 0.0 2.3 8.4 0.0 3.1 3 0 0 3 3 3 2 RNA helicase MMR_HSR1 PF01926.18 EWC46884.1 - 0.0014 18.5 0.1 0.43 10.5 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_10 PF12846.2 EWC46884.1 - 0.0023 17.4 0.4 2.2 7.6 0.1 2.5 2 0 0 2 2 2 2 AAA-like domain NACHT PF05729.7 EWC46884.1 - 0.0025 17.4 0.3 0.15 11.7 0.1 2.4 2 0 0 2 2 2 1 NACHT domain UPF0079 PF02367.12 EWC46884.1 - 0.0046 16.5 0.8 0.024 14.2 0.3 2.1 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 AAA_19 PF13245.1 EWC46884.1 - 0.0046 16.6 0.6 0.3 10.8 0.1 2.6 2 0 0 2 2 2 1 Part of AAA domain AAA_30 PF13604.1 EWC46884.1 - 0.0053 16.3 0.2 0.73 9.3 0.2 2.3 2 0 0 2 2 2 1 AAA domain AAA PF00004.24 EWC46884.1 - 0.0067 16.6 0.1 1.3 9.2 0.0 3.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.1 EWC46884.1 - 0.0069 16.3 0.3 0.0069 16.3 0.2 2.6 3 0 0 3 3 2 1 AAA domain AAA_23 PF13476.1 EWC46884.1 - 0.0076 16.5 0.0 0.021 15.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain APS_kinase PF01583.15 EWC46884.1 - 0.014 15.0 0.0 0.045 13.4 0.0 1.8 1 0 0 1 1 1 0 Adenylylsulphate kinase cobW PF02492.14 EWC46884.1 - 0.017 14.5 1.7 0.16 11.3 0.4 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ResIII PF04851.10 EWC46884.1 - 0.049 13.4 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit T2SE PF00437.15 EWC46884.1 - 0.054 12.3 0.3 4.8 5.9 0.1 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein Miro PF08477.8 EWC46884.1 - 0.076 13.5 0.0 5.4 7.5 0.0 2.7 2 0 0 2 2 2 0 Miro-like protein ABC_ATPase PF09818.4 EWC46884.1 - 0.18 10.3 0.3 0.4 9.2 0.2 1.5 1 0 0 1 1 1 0 Predicted ATPase of the ABC class PduV-EutP PF10662.4 EWC46884.1 - 0.22 10.9 0.6 0.82 9.1 0.2 2.0 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation CAP_N PF01213.14 EWC46884.1 - 0.48 9.6 5.9 1.1 8.5 4.1 1.5 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal AAA_15 PF13175.1 EWC46884.1 - 0.75 8.7 0.0 1.7 7.5 0.0 1.5 2 0 0 2 2 1 0 AAA ATPase domain Mito_fiss_reg PF05308.6 EWC46884.1 - 1 8.6 6.3 2 7.7 4.4 1.4 1 0 0 1 1 1 0 Mitochondrial fission regulator PTPA PF03095.10 EWC46885.1 - 6.3e-92 307.9 0.0 1.7e-89 299.9 0.0 2.0 1 1 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein RE_Eco29kI PF09517.5 EWC46886.1 - 0.023 14.0 0.8 0.051 12.8 0.0 1.9 2 0 0 2 2 2 0 Eco29kI restriction endonuclease PNP_UDP_1 PF01048.15 EWC46887.1 - 3.1e-37 127.7 0.1 3.9e-37 127.4 0.1 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily PAP1 PF08601.5 EWC46888.1 - 2e-41 142.8 23.6 2e-41 142.8 16.4 3.0 1 1 2 3 3 2 1 Transcription factor PAP1 bZIP_1 PF00170.16 EWC46888.1 - 6.5e-10 38.8 12.7 1.2e-09 37.9 8.8 1.4 1 0 0 1 1 1 1 bZIP transcription factor GAS PF13851.1 EWC46888.1 - 0.0016 17.6 9.6 0.0025 17.0 6.7 1.2 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding IncA PF04156.9 EWC46888.1 - 0.0045 16.6 5.1 0.0077 15.8 3.5 1.3 1 0 0 1 1 1 1 IncA protein DUF972 PF06156.8 EWC46888.1 - 0.0089 16.3 1.4 0.021 15.1 0.9 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF972) bZIP_2 PF07716.10 EWC46888.1 - 0.011 15.4 17.4 0.024 14.4 11.0 2.1 1 1 1 2 2 2 0 Basic region leucine zipper DUF4635 PF15466.1 EWC46888.1 - 0.019 14.2 0.4 0.034 13.4 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4635) Herpes_UL6 PF01763.11 EWC46888.1 - 0.044 11.9 3.2 0.066 11.3 2.2 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like bZIP_Maf PF03131.12 EWC46888.1 - 0.065 13.5 12.5 0.12 12.6 8.7 1.4 1 0 0 1 1 1 0 bZIP Maf transcription factor DivIC PF04977.10 EWC46888.1 - 0.075 12.5 8.2 0.14 11.6 5.7 1.4 1 0 0 1 1 1 0 Septum formation initiator Adeno_PIX PF03955.9 EWC46888.1 - 0.087 13.3 1.5 0.3 11.6 1.0 1.9 1 0 0 1 1 1 0 Adenovirus hexon-associated protein (IX) dsrm PF00035.20 EWC46888.1 - 0.11 13.0 0.1 0.27 11.8 0.1 1.6 1 0 0 1 1 1 0 Double-stranded RNA binding motif DUF812 PF05667.6 EWC46888.1 - 0.12 10.8 6.4 0.21 10.0 4.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF812) ALMT PF11744.3 EWC46888.1 - 0.2 10.3 0.1 1.6 7.3 0.0 1.9 2 0 0 2 2 2 0 Aluminium activated malate transporter Prominin PF05478.6 EWC46888.1 - 0.2 9.1 1.7 0.3 8.5 1.2 1.1 1 0 0 1 1 1 0 Prominin PSI_PsaF PF02507.10 EWC46888.1 - 0.25 10.8 0.7 0.46 10.0 0.5 1.3 1 0 0 1 1 1 0 Photosystem I reaction centre subunit III Fzo_mitofusin PF04799.8 EWC46888.1 - 0.26 10.6 4.4 0.43 9.9 3.0 1.2 1 0 0 1 1 1 0 fzo-like conserved region FlaC_arch PF05377.6 EWC46888.1 - 0.29 11.0 4.0 0.6 10.0 2.7 1.5 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) ACCA PF03255.9 EWC46888.1 - 0.36 10.3 4.4 0.59 9.6 3.0 1.3 1 0 0 1 1 1 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Glutaredoxin2_C PF04399.8 EWC46888.1 - 0.42 10.2 2.3 0.82 9.2 1.6 1.4 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain APG6 PF04111.7 EWC46888.1 - 1.1 8.1 6.1 1.9 7.4 4.2 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 V_ATPase_I PF01496.14 EWC46888.1 - 1.5 6.5 2.4 2.3 5.9 1.6 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SPT16 PF08644.6 EWC46888.1 - 1.7 8.4 5.3 3.1 7.6 3.7 1.3 1 0 0 1 1 1 0 FACT complex subunit (SPT16/CDC68) Phlebovirus_NSM PF07246.6 EWC46888.1 - 2.4 7.2 6.3 3.6 6.6 4.4 1.2 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M Bap31 PF05529.7 EWC46888.1 - 7.6 5.9 9.5 14 5.0 6.6 1.3 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like SMN PF06003.7 EWC46889.1 - 2.2e-07 30.2 0.1 2.2e-07 30.2 0.1 1.8 1 1 0 2 2 2 1 Survival motor neuron protein (SMN) Fis1_TPR_C PF14853.1 EWC46889.1 - 0.041 13.7 0.4 0.073 12.9 0.3 1.3 1 0 0 1 1 1 0 Fis1 C-terminal tetratricopeptide repeat DUF4537 PF15057.1 EWC46889.1 - 0.12 12.1 0.1 0.21 11.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4537) WHEP-TRS PF00458.15 EWC46889.1 - 1.2 8.8 6.0 4.1 7.1 0.1 2.9 2 1 0 2 2 2 0 WHEP-TRS domain DEAD PF00270.24 EWC46890.1 - 1.8e-40 138.2 0.1 3.6e-40 137.2 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EWC46890.1 - 1.3e-18 66.6 0.1 5e-18 64.7 0.1 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF1253 PF06862.7 EWC46890.1 - 0.027 12.8 0.0 2.5 6.4 0.0 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1253) ResIII PF04851.10 EWC46890.1 - 0.034 13.9 0.0 0.034 13.9 0.0 2.5 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit RCC1 PF00415.13 EWC46891.1 - 8.3e-28 96.3 0.5 3.5e-10 39.9 0.1 5.4 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.26 EWC46891.1 - 1.1e-11 44.6 0.0 2.6e-09 37.0 0.0 2.7 2 0 0 2 2 2 1 BTB/POZ domain Ank_4 PF13637.1 EWC46891.1 - 1.4e-09 38.2 0.1 3.4e-09 36.9 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 EWC46891.1 - 9.5e-08 31.5 0.1 0.0042 17.1 0.1 3.0 2 0 0 2 2 2 2 Ankyrin repeat RCC1_2 PF13540.1 EWC46891.1 - 1.4e-07 30.8 0.5 1.4e-07 30.8 0.3 3.9 4 0 0 4 4 4 1 Regulator of chromosome condensation (RCC1) repeat Ank_2 PF12796.2 EWC46891.1 - 8e-07 29.3 0.0 2.4e-06 27.7 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.1 EWC46891.1 - 2.7e-05 24.2 0.0 0.0011 19.1 0.1 2.6 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.25 EWC46891.1 - 0.00016 21.3 0.1 0.15 11.8 0.1 2.7 2 0 0 2 2 2 2 Ankyrin repeat Epimerase PF01370.16 EWC46892.1 - 9.5e-07 28.4 0.0 3.2e-05 23.4 0.0 2.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 EWC46892.1 - 1e-06 28.9 0.3 1.3e-05 25.2 0.2 2.3 1 1 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 EWC46892.1 - 5.3e-05 22.5 0.2 0.04 13.1 0.1 2.4 2 1 1 3 3 3 2 NmrA-like family Semialdhyde_dh PF01118.19 EWC46892.1 - 0.0036 17.5 0.0 0.019 15.2 0.0 2.1 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain Polysacc_synt_2 PF02719.10 EWC46892.1 - 0.0049 15.8 0.0 0.16 10.8 0.0 2.1 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein DUF1471 PF07338.8 EWC46892.1 - 0.024 14.2 0.2 0.064 12.9 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1471) NAD_binding_4 PF07993.7 EWC46892.1 - 0.098 11.5 0.0 0.6 8.9 0.0 2.1 2 1 1 3 3 3 0 Male sterility protein DUF2433 PF10360.4 EWC46893.1 - 6e-49 165.7 0.0 1e-48 164.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2433) Metallophos_2 PF12850.2 EWC46893.1 - 0.015 15.1 0.0 0.046 13.5 0.0 1.8 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain Patched PF02460.13 EWC46894.1 - 1.4e-81 274.6 9.2 7.8e-52 176.2 0.0 2.1 2 0 0 2 2 2 2 Patched family Sterol-sensing PF12349.3 EWC46894.1 - 3.1e-53 179.3 4.4 3.1e-53 179.3 3.0 3.0 2 1 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.10 EWC46894.1 - 0.00015 20.6 25.9 0.00027 19.7 5.4 2.4 2 0 0 2 2 2 2 MMPL family ACR_tran PF00873.14 EWC46894.1 - 0.26 8.6 11.1 0.5 7.7 7.7 1.4 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family Solute_trans_a PF03619.11 EWC46895.1 - 3.3e-77 259.4 18.9 4e-77 259.2 13.1 1.0 1 0 0 1 1 1 1 Organic solute transporter Ostalpha NapE PF06796.6 EWC46895.1 - 0.12 11.7 2.0 0.27 10.5 0.0 2.6 2 0 0 2 2 2 0 Periplasmic nitrate reductase protein NapE zf-DHHC PF01529.15 EWC46895.1 - 4.4 6.6 9.9 2.3 7.5 0.0 2.7 1 1 0 2 2 2 0 DHHC palmitoyltransferase ECH PF00378.15 EWC46896.1 - 1.2e-39 135.8 0.3 1.8e-39 135.3 0.2 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family ECH_C PF13766.1 EWC46896.1 - 0.059 13.5 0.0 0.1 12.7 0.0 1.3 1 0 0 1 1 1 0 2-enoyl-CoA Hydratase C-terminal region Kelch_3 PF13415.1 EWC46897.1 - 5.3e-06 26.4 0.7 2.4 8.4 0.0 4.1 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_4 PF13418.1 EWC46897.1 - 3.6e-05 23.4 0.8 1.6 8.5 0.1 4.2 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_1 PF01344.20 EWC46897.1 - 0.0016 17.9 0.1 5 6.7 0.0 3.6 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.1 EWC46897.1 - 0.0028 17.7 5.4 3.5 7.9 0.0 4.2 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.1 EWC46897.1 - 0.019 14.9 6.1 2.5 8.1 0.1 4.4 4 0 0 4 4 4 0 Kelch motif DUF3328 PF11807.3 EWC46898.1 - 3.1e-47 161.0 0.1 4.3e-47 160.5 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) HEAT_EZ PF13513.1 EWC46899.1 - 3.9e-23 81.2 5.5 4.1e-08 33.4 1.4 9.5 8 2 2 10 10 8 4 HEAT-like repeat HEAT_2 PF13646.1 EWC46899.1 - 4.6e-23 81.3 10.1 8.5e-08 32.3 0.2 8.1 6 2 1 8 8 8 4 HEAT repeats HEAT PF02985.17 EWC46899.1 - 2.1e-16 58.4 10.8 0.00075 19.3 0.1 10.8 13 0 0 13 13 11 3 HEAT repeat UME PF08064.8 EWC46899.1 - 5.4e-11 42.3 0.1 0.014 15.3 0.0 5.7 6 0 0 6 6 6 2 UME (NUC010) domain Arm PF00514.18 EWC46899.1 - 3.8e-10 39.2 10.0 0.32 10.8 0.1 7.5 8 0 0 8 8 6 2 Armadillo/beta-catenin-like repeat Adaptin_N PF01602.15 EWC46899.1 - 7.3e-10 37.7 0.2 2.9e-07 29.2 0.0 3.9 3 1 1 5 5 5 1 Adaptin N terminal region IBN_N PF03810.14 EWC46899.1 - 5.3e-09 35.8 2.5 8.7e-07 28.7 0.3 3.5 2 1 1 3 3 3 1 Importin-beta N-terminal domain Vac14_Fab1_bd PF12755.2 EWC46899.1 - 1.1e-07 32.0 0.0 0.0064 16.8 0.0 5.7 4 1 2 6 6 6 1 Vacuolar 14 Fab1-binding region CLASP_N PF12348.3 EWC46899.1 - 3.9e-07 29.6 0.0 1.2 8.4 0.0 6.0 3 2 2 6 6 6 3 CLASP N terminal Cnd1 PF12717.2 EWC46899.1 - 9.9e-07 28.7 5.0 0.25 11.1 0.0 5.3 5 1 0 5 5 5 2 non-SMC mitotic condensation complex subunit 1 MMS19_C PF12460.3 EWC46899.1 - 1e-06 27.7 1.1 0.11 11.2 0.0 5.6 5 1 1 6 6 6 1 RNAPII transcription regulator C-terminal ParcG PF10274.4 EWC46899.1 - 4.7e-06 26.6 0.0 0.0081 16.0 0.0 3.0 3 0 0 3 3 3 2 Parkin co-regulated protein Ipi1_N PF12333.3 EWC46899.1 - 0.0001 22.2 0.1 0.047 13.6 0.0 4.5 3 1 1 4 4 4 1 Rix1 complex component involved in 60S ribosome maturation Cohesin_HEAT PF12765.2 EWC46899.1 - 0.00054 19.8 0.8 0.029 14.3 0.1 3.5 3 0 0 3 3 3 1 HEAT repeat associated with sister chromatid cohesion HEAT_PBS PF03130.11 EWC46899.1 - 0.0024 18.1 8.4 0.3 11.6 0.1 6.5 8 0 0 8 8 6 1 PBS lyase HEAT-like repeat IFRD PF05004.8 EWC46899.1 - 0.004 16.2 0.4 1.8 7.5 0.0 3.3 2 1 0 3 3 3 1 Interferon-related developmental regulator (IFRD) DUF4042 PF13251.1 EWC46899.1 - 0.0061 16.0 0.1 0.31 10.4 0.0 3.8 3 0 0 3 3 3 1 Domain of unknown function (DUF4042) V-ATPase_H_C PF11698.3 EWC46899.1 - 0.29 11.0 1.6 51 3.8 0.0 4.3 3 1 1 4 4 4 0 V-ATPase subunit H SNF2_N PF00176.18 EWC46900.1 - 2.9e-71 239.7 0.3 2.6e-70 236.5 0.2 2.1 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 EWC46900.1 - 6.4e-12 45.1 0.0 1.4e-11 44.0 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain COG4 PF08318.7 EWC46900.1 - 0.085 11.6 0.1 0.31 9.7 0.0 2.0 2 0 0 2 2 2 0 COG4 transport protein Nop14 PF04147.7 EWC46900.1 - 0.77 7.6 36.4 1.9 6.2 25.2 1.6 1 0 0 1 1 1 0 Nop14-like family Daxx PF03344.10 EWC46900.1 - 3.7 5.9 39.0 0.024 13.1 21.0 1.7 2 0 0 2 2 2 0 Daxx Family PHY PF00360.15 EWC46901.1 - 4e-28 97.7 0.0 8.2e-28 96.7 0.0 1.4 1 0 0 1 1 1 1 Phytochrome region HATPase_c PF02518.21 EWC46901.1 - 2.5e-17 62.6 0.3 7.2e-17 61.1 0.0 1.9 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.19 EWC46901.1 - 5.3e-15 55.3 0.0 1.7e-14 53.7 0.0 1.9 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.20 EWC46901.1 - 8.7e-15 54.4 0.7 2.2e-14 53.2 0.5 1.7 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain GAF PF01590.21 EWC46901.1 - 2.4e-13 50.4 0.0 9.1e-13 48.6 0.0 2.0 2 0 0 2 2 2 1 GAF domain PAS_2 PF08446.6 EWC46901.1 - 5.5e-06 26.7 0.0 1.5e-05 25.3 0.0 1.8 1 0 0 1 1 1 1 PAS fold LAMTOR PF15454.1 EWC46902.1 - 8.5e-14 51.5 0.2 1.3e-13 51.0 0.1 1.3 1 0 0 1 1 1 1 Late endosomal/lysosomal adaptor and MAPK and MTOR activator Spc7 PF08317.6 EWC46904.1 - 0.00082 18.1 12.9 0.00082 18.1 8.9 4.9 2 1 3 5 5 5 2 Spc7 kinetochore protein Ribosomal_L33 PF00471.15 EWC46905.1 - 0.1 12.8 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L33 DUF2178 PF09946.4 EWC46905.1 - 0.1 12.3 0.0 0.1 12.3 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2178) HPP PF04982.8 EWC46907.1 - 3.6e-38 130.0 2.6 6.3e-38 129.3 1.8 1.4 1 0 0 1 1 1 1 HPP family Med13_C PF06333.7 EWC46908.1 - 1.8e-80 270.5 0.0 3e-80 269.8 0.0 1.4 1 0 0 1 1 1 1 Mediator complex subunit 13 C-terminal Med13_N PF11597.3 EWC46908.1 - 2e-06 26.7 0.2 0.057 12.0 0.0 2.6 2 0 0 2 2 2 2 Mediator complex subunit 13 N-terminal Tyrosinase PF00264.15 EWC46909.1 - 5e-46 157.6 1.5 5e-46 157.6 1.1 1.9 2 0 0 2 2 2 1 Common central domain of tyrosinase zf-Nse PF11789.3 EWC46910.1 - 2.4e-16 58.9 0.5 4.3e-16 58.1 0.4 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.1 EWC46910.1 - 4.6e-05 23.0 0.1 0.00011 21.8 0.1 1.7 1 0 0 1 1 1 1 RING-type zinc-finger Rtf2 PF04641.7 EWC46910.1 - 8.3e-05 21.9 9.6 0.00029 20.1 6.7 1.8 1 1 0 1 1 1 1 Rtf2 RING-finger zf-MIZ PF02891.15 EWC46910.1 - 0.004 16.6 0.2 0.0067 15.9 0.2 1.4 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger UBN_AB PF14075.1 EWC46910.1 - 0.012 15.3 3.0 0.89 9.1 0.0 2.5 2 0 0 2 2 2 0 Ubinuclein conserved middle domain Nha1_C PF08619.5 EWC46910.1 - 0.041 13.1 26.7 0.015 14.5 16.9 1.6 1 1 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus DUF1908 PF08926.6 EWC46910.1 - 0.051 12.3 0.2 0.17 10.6 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1908) zf-RING_2 PF13639.1 EWC46910.1 - 0.11 12.3 0.3 0.18 11.6 0.2 1.4 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4_2 PF13923.1 EWC46910.1 - 0.22 11.6 0.6 0.36 10.8 0.4 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Daxx PF03344.10 EWC46910.1 - 8.9 4.6 21.0 17 3.7 14.6 1.5 1 0 0 1 1 1 0 Daxx Family PEX11 PF05648.9 EWC46911.1 - 8.9e-68 227.8 0.6 1e-67 227.7 0.4 1.0 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) Ank_2 PF12796.2 EWC46912.1 - 1e-17 64.2 0.0 9.2e-08 32.3 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 EWC46912.1 - 1.4e-17 62.5 1.0 4.8e-06 26.1 0.0 4.1 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.1 EWC46912.1 - 4.8e-13 47.9 0.0 0.037 14.2 0.0 4.7 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.1 EWC46912.1 - 1.6e-12 47.2 0.4 0.00049 20.2 0.0 3.9 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.1 EWC46912.1 - 6.5e-12 45.6 0.1 1.1e-05 25.7 0.0 3.5 3 1 0 3 3 3 2 Ankyrin repeats (many copies) DUF3937 PF13073.1 EWC46912.1 - 0.46 10.3 8.9 0.099 12.5 0.7 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3937) Aminotran_1_2 PF00155.16 EWC46913.1 - 4.3e-38 131.2 0.0 1.6e-37 129.3 0.0 1.7 2 0 0 2 2 2 1 Aminotransferase class I and II SieB PF14163.1 EWC46914.1 - 0.049 13.2 0.1 0.075 12.6 0.0 1.3 1 0 0 1 1 1 0 Superinfection exclusion protein B Herpes_gE PF02480.11 EWC46914.1 - 0.068 11.4 0.2 0.087 11.0 0.1 1.1 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E PetG PF02529.10 EWC46914.1 - 0.075 12.5 0.0 0.16 11.4 0.0 1.5 1 0 0 1 1 1 0 Cytochrome B6-F complex subunit 5 NfeD PF01957.13 EWC46914.1 - 0.092 12.8 0.2 0.12 12.5 0.2 1.4 1 1 0 1 1 1 0 NfeD-like C-terminal, partner-binding DUF2648 PF10855.3 EWC46914.1 - 0.12 11.8 0.9 0.22 10.9 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2648) DUF202 PF02656.10 EWC46914.1 - 0.13 12.4 2.2 0.3 11.3 1.5 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF202) DUF4293 PF14126.1 EWC46914.1 - 0.14 12.0 0.3 0.21 11.5 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4293) NUC153 PF08159.7 EWC46915.1 - 5.2e-11 41.9 0.1 9.5e-11 41.0 0.1 1.4 1 0 0 1 1 1 1 NUC153 domain WD40 PF00400.27 EWC46915.1 - 0.00034 20.3 0.0 0.0042 16.9 0.0 2.5 2 0 0 2 2 2 1 WD domain, G-beta repeat Pox_MCEL PF03291.11 EWC46916.1 - 2.1e-64 217.5 0.0 5.3e-64 216.1 0.0 1.6 1 1 0 1 1 1 1 mRNA capping enzyme Methyltransf_12 PF08242.7 EWC46916.1 - 1.7e-08 34.8 0.0 4.9e-08 33.3 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EWC46916.1 - 6.5e-07 29.9 0.0 1.1e-06 29.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EWC46916.1 - 2e-05 24.1 0.0 8.6e-05 22.1 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 EWC46916.1 - 8.7e-05 22.2 0.0 0.00017 21.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EWC46916.1 - 0.0012 19.2 0.0 0.046 14.1 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EWC46916.1 - 0.0059 16.9 0.0 0.013 15.8 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.12 EWC46916.1 - 0.0098 14.8 0.0 0.021 13.8 0.0 1.4 1 0 0 1 1 1 1 NNMT/PNMT/TEMT family Cep57_CLD_2 PF14197.1 EWC46916.1 - 3.7 7.5 7.9 29 4.7 2.4 2.5 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 RPN7 PF10602.4 EWC46917.1 - 1.1e-55 187.8 2.5 1.7e-55 187.1 1.7 1.3 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.22 EWC46917.1 - 3e-13 50.0 0.0 3.2e-12 46.6 0.0 2.3 2 0 0 2 2 2 1 PCI domain An_peroxidase PF03098.10 EWC46918.1 - 6.7e-95 318.4 0.0 9e-93 311.4 0.0 2.1 1 1 0 1 1 1 1 Animal haem peroxidase PLDc PF00614.17 EWC46919.1 - 3.7e-16 58.3 2.0 1.2e-07 31.3 0.1 2.9 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_2 PF13091.1 EWC46919.1 - 6.2e-16 58.2 0.9 2e-07 30.7 0.1 3.6 3 0 0 3 3 3 3 PLD-like domain Mito_carr PF00153.22 EWC46920.1 - 2.9e-52 174.3 3.0 1e-18 66.8 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Peptidase_C15 PF01470.12 EWC46921.1 - 0.00017 21.4 0.1 0.28 10.9 0.0 3.3 3 1 0 3 3 3 2 Pyroglutamyl peptidase DUF1075 PF06388.6 EWC46921.1 - 0.24 11.0 1.1 8.6 5.9 0.1 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1075) MOSC_N PF03476.11 EWC46922.1 - 2.7e-12 46.4 0.0 9.5e-10 38.2 0.0 2.5 2 0 0 2 2 2 2 MOSC N-terminal beta barrel domain MOSC PF03473.12 EWC46922.1 - 1.9e-11 43.5 0.0 3.4e-11 42.7 0.0 1.3 1 0 0 1 1 1 1 MOSC domain Peptidase_C14 PF00656.17 EWC46923.1 - 1e-68 231.7 0.0 1.3e-68 231.4 0.0 1.1 1 0 0 1 1 1 1 Caspase domain Zn_clus PF00172.13 EWC46925.1 - 3.6e-09 36.3 8.0 3.6e-09 36.3 5.6 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 EWC46925.1 - 7.5e-08 31.5 0.2 1.2e-07 30.9 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain SET PF00856.23 EWC46925.1 - 0.0054 17.0 0.0 0.56 10.4 0.0 2.8 2 1 0 2 2 2 1 SET domain DUF1983 PF09327.6 EWC46926.1 - 0.11 12.5 0.1 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1983) SHMT PF00464.14 EWC46927.1 - 7.1e-197 653.5 0.0 8.4e-197 653.3 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Beta_elim_lyase PF01212.16 EWC46927.1 - 0.026 13.6 0.0 0.052 12.6 0.0 1.4 1 1 0 1 1 1 0 Beta-eliminating lyase Mg_trans_NIPA PF05653.9 EWC46928.1 - 3.3e-91 305.3 20.6 4.5e-91 304.9 14.3 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA EmrE PF13536.1 EWC46928.1 - 4.5e-07 30.0 4.3 4.5e-07 30.0 3.0 3.1 2 1 1 3 3 3 1 Multidrug resistance efflux transporter EamA PF00892.15 EWC46928.1 - 1e-06 28.8 4.7 1e-06 28.8 3.2 3.6 3 1 0 3 3 3 1 EamA-like transporter family DUF843 PF05814.6 EWC46928.1 - 0.4 10.5 2.3 0.53 10.1 0.2 2.2 2 0 0 2 2 2 0 Baculovirus protein of unknown function (DUF843) DUF1129 PF06570.6 EWC46928.1 - 2.1 7.6 12.8 1.3 8.3 4.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) Mcp5_PH PF12814.2 EWC46929.1 - 7.3e-43 145.3 0.0 1.5e-42 144.4 0.0 1.5 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology Lactococcin_972 PF09683.5 EWC46929.1 - 0.0057 16.9 0.6 0.02 15.2 0.4 1.9 1 0 0 1 1 1 1 Bacteriocin (Lactococcin_972) YebO PF13974.1 EWC46929.1 - 0.38 10.5 1.5 0.74 9.6 0.1 2.3 2 0 0 2 2 2 0 YebO-like protein Tweety PF04906.8 EWC46929.1 - 0.8 8.0 1.1 1.4 7.2 0.8 1.3 1 0 0 1 1 1 0 Tweety Ras PF00071.17 EWC46930.1 - 2.6e-51 173.1 0.3 2.1e-50 170.2 0.2 1.9 1 1 0 1 1 1 1 Ras family Miro PF08477.8 EWC46930.1 - 2.7e-18 66.5 0.0 2.6e-15 56.9 0.0 2.3 2 0 0 2 2 2 2 Miro-like protein Arf PF00025.16 EWC46930.1 - 0.00026 20.2 0.1 0.0023 17.1 0.0 1.9 2 0 0 2 2 2 1 ADP-ribosylation factor family SRPRB PF09439.5 EWC46930.1 - 0.003 16.7 0.0 0.82 8.8 0.0 2.1 2 0 0 2 2 2 2 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.18 EWC46930.1 - 0.0058 16.5 0.0 0.0083 16.0 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_25 PF13481.1 EWC46930.1 - 0.051 12.9 0.0 0.083 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain Septin PF00735.13 EWC46930.1 - 0.075 12.0 0.6 0.19 10.7 0.0 1.8 3 0 0 3 3 3 0 Septin FeoB_N PF02421.13 EWC46930.1 - 0.12 11.6 0.5 1.3 8.3 0.0 2.3 2 1 1 3 3 3 0 Ferrous iron transport protein B CH PF00307.26 EWC46931.1 - 5.5e-58 193.6 0.0 4e-17 62.2 0.1 4.1 4 0 0 4 4 4 4 Calponin homology (CH) domain EF-hand_7 PF13499.1 EWC46931.1 - 0.00087 19.3 0.8 0.0025 17.8 0.5 1.8 1 0 0 1 1 1 1 EF-hand domain pair CAMSAP_CH PF11971.3 EWC46931.1 - 0.018 14.6 0.0 5.4 6.7 0.0 3.1 3 0 0 3 3 3 0 CAMSAP CH domain SAICAR_synt PF01259.13 EWC46934.1 - 2.5e-93 311.7 0.0 2.9e-93 311.5 0.0 1.0 1 0 0 1 1 1 1 SAICAR synthetase ABC_tran PF00005.22 EWC46935.1 - 7.7e-35 120.1 0.0 1.4e-34 119.3 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.18 EWC46935.1 - 5.7e-16 58.7 12.9 5.7e-16 58.7 9.0 1.8 2 0 0 2 2 2 1 ABC transporter transmembrane region SMC_N PF02463.14 EWC46935.1 - 0.00029 20.1 0.1 0.012 14.8 0.0 2.5 2 1 1 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.1 EWC46935.1 - 0.00037 20.5 0.0 0.00099 19.1 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 EWC46935.1 - 0.0011 19.1 0.0 0.0039 17.3 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_21 PF13304.1 EWC46935.1 - 0.0012 18.8 0.1 0.16 11.9 0.1 2.7 1 1 0 1 1 1 1 AAA domain DUF258 PF03193.11 EWC46935.1 - 0.0035 16.5 0.0 0.021 14.0 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_29 PF13555.1 EWC46935.1 - 0.011 15.2 0.0 0.032 13.7 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain Zeta_toxin PF06414.7 EWC46935.1 - 0.012 14.6 0.0 0.023 13.7 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin MMR_HSR1 PF01926.18 EWC46935.1 - 0.04 13.8 0.0 0.19 11.6 0.0 2.1 2 0 0 2 2 2 0 50S ribosome-binding GTPase DUF87 PF01935.12 EWC46935.1 - 0.042 13.6 0.1 0.081 12.7 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function DUF87 AAA_23 PF13476.1 EWC46935.1 - 0.056 13.7 0.0 0.14 12.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.1 EWC46935.1 - 0.11 13.3 0.0 0.32 11.8 0.0 1.9 1 0 0 1 1 1 0 AAA domain Glyco_transf_34 PF05637.7 EWC46936.1 - 5.1e-31 108.0 0.0 6.9e-31 107.5 0.0 1.2 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family Endonuc-FokI_C PF09254.6 EWC46936.1 - 0.092 11.8 0.2 0.15 11.1 0.1 1.2 1 0 0 1 1 1 0 Restriction endonuclease FokI, C terminal DRMBL PF07522.9 EWC46937.1 - 9.1e-34 115.8 0.0 1.7e-33 114.9 0.0 1.5 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.2 EWC46937.1 - 3.4e-11 43.0 0.0 7.1e-11 42.0 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain LSM PF01423.17 EWC46938.1 - 7.2e-16 57.4 0.6 1e-15 57.0 0.4 1.2 1 0 0 1 1 1 1 LSM domain Gemin7 PF11095.3 EWC46938.1 - 0.013 15.2 0.0 0.027 14.2 0.0 1.5 1 0 0 1 1 1 0 Gem-associated protein 7 (Gemin7) SM-ATX PF14438.1 EWC46938.1 - 0.019 14.8 0.1 0.024 14.5 0.0 1.2 1 0 0 1 1 1 0 Ataxin 2 SM domain Ribosomal_L37 PF08561.5 EWC46939.1 - 1.3e-22 79.1 1.7 6.8e-22 76.8 1.2 2.0 1 1 0 1 1 1 1 Mitochondrial ribosomal protein L37 RRM_1 PF00076.17 EWC46940.1 - 3.9e-42 141.7 0.0 5.3e-20 70.8 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EWC46940.1 - 6.1e-34 115.8 0.0 1.9e-17 63.0 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EWC46940.1 - 7.3e-19 67.3 0.0 9.9e-11 41.3 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 EWC46940.1 - 0.019 14.7 0.0 3 7.6 0.0 2.3 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif Surp PF01805.15 EWC46942.1 - 2e-17 62.5 0.0 4.2e-17 61.5 0.0 1.6 1 0 0 1 1 1 1 Surp module DUF202 PF02656.10 EWC46943.1 - 0.1 12.7 0.0 2.1 8.6 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF202) Glyco_hyd_65N_2 PF14498.1 EWC46944.1 - 8.9e-61 205.5 0.0 1.2e-60 205.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain Ku_C PF03730.9 EWC46944.1 - 0.2 12.1 0.0 0.42 11.1 0.0 1.5 1 0 0 1 1 1 0 Ku70/Ku80 C-terminal arm Phage_GPD PF05954.6 EWC46945.1 - 0.27 10.3 2.2 0.33 10.1 1.5 1.1 1 0 0 1 1 1 0 Phage late control gene D protein (GPD) DUF4078 PF13300.1 EWC46946.1 - 2.1e-20 72.5 21.4 2.1e-20 72.5 14.8 3.8 3 1 1 4 4 4 1 Domain of unknown function (DUF4078) CENP-H PF05837.7 EWC46947.1 - 2e-14 53.6 0.5 2e-14 53.6 0.3 1.9 2 1 1 3 3 3 1 Centromere protein H (CENP-H) ATG16 PF08614.6 EWC46947.1 - 3.6 7.3 9.6 19 4.9 5.5 2.3 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) Ish1 PF10281.4 EWC46949.1 - 4.9e-83 272.7 31.0 3.8e-13 49.2 0.4 8.3 8 0 0 8 8 8 8 Putative stress-responsive nuclear envelope protein HeH PF12949.2 EWC46949.1 - 5.8e-16 57.7 0.0 0.00011 21.6 0.0 7.2 8 0 0 8 8 8 5 HeH/LEM domain SAP PF02037.22 EWC46949.1 - 3.6e-10 39.0 0.0 0.69 9.4 0.0 7.3 6 2 0 6 6 6 2 SAP domain Slx4 PF09494.5 EWC46949.1 - 5.6e-09 35.6 2.9 0.046 13.4 0.0 6.2 7 0 0 7 7 7 3 Slx4 endonuclease APC2 PF08672.6 EWC46949.1 - 1.2e-05 25.4 1.4 8 6.7 0.0 6.3 7 0 0 7 7 7 1 Anaphase promoting complex (APC) subunit 2 Alpha_kinase PF02816.13 EWC46949.1 - 0.059 13.0 0.0 0.31 10.6 0.0 2.1 2 0 0 2 2 2 0 Alpha-kinase family DUF883 PF05957.8 EWC46949.1 - 0.12 12.8 13.5 0.77 10.1 0.7 3.6 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF883) SAM_2 PF07647.12 EWC46949.1 - 1.4 8.8 11.8 1.1 9.2 0.1 5.0 6 0 0 6 6 6 0 SAM domain (Sterile alpha motif) HMG_CoA_synt_C PF08540.5 EWC46950.1 - 6.4e-102 340.8 0.4 8.7e-102 340.3 0.3 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.12 EWC46950.1 - 1.9e-95 317.3 0.2 2.8e-95 316.7 0.2 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal ACP_syn_III PF08545.5 EWC46950.1 - 0.057 13.0 0.1 0.11 12.1 0.1 1.4 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III O-antigen_lig PF13425.1 EWC46951.1 - 0.049 13.6 2.7 0.054 13.4 1.9 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DXP_synthase_N PF13292.1 EWC46952.1 - 0.047 12.6 2.0 0.35 9.7 0.2 2.2 2 0 0 2 2 2 0 1-deoxy-D-xylulose-5-phosphate synthase HR1 PF02185.11 EWC46952.1 - 0.076 12.7 14.5 0.37 10.5 0.0 3.2 3 0 0 3 3 3 0 Hr1 repeat RRM_1 PF00076.17 EWC46953.1 - 4.1e-16 58.3 0.0 5.7e-16 57.8 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EWC46953.1 - 1.2e-12 47.5 0.0 1.8e-12 47.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EWC46953.1 - 9.3e-09 35.0 0.0 1.5e-08 34.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Homeobox_KN PF05920.6 EWC46954.1 - 1.9e-20 72.2 2.5 5.1e-20 70.8 0.3 2.5 2 0 0 2 2 2 1 Homeobox KN domain Homeobox PF00046.24 EWC46954.1 - 9.5e-07 28.3 2.1 2e-06 27.3 0.2 2.4 2 0 0 2 2 2 1 Homeobox domain NUDE_C PF04880.8 EWC46955.1 - 5.7e-09 36.5 22.5 5.7e-09 36.5 15.6 3.7 2 1 1 3 3 3 1 NUDE protein, C-terminal conserved region DUF904 PF06005.7 EWC46955.1 - 0.0099 16.1 8.2 0.0099 16.1 5.7 3.8 3 1 1 4 4 4 2 Protein of unknown function (DUF904) CENP-F_leu_zip PF10473.4 EWC46955.1 - 0.64 9.8 33.9 0.063 13.1 13.0 2.8 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 IncA PF04156.9 EWC46955.1 - 0.69 9.4 38.8 0.3 10.6 8.0 2.5 2 1 1 3 3 3 0 IncA protein WEMBL PF05701.6 EWC46955.1 - 0.79 8.1 32.7 1.2 7.5 22.7 1.1 1 0 0 1 1 1 0 Weak chloroplast movement under blue light DUF1515 PF07439.6 EWC46955.1 - 1.6 8.5 5.9 2.1 8.2 1.2 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1515) TMPIT PF07851.8 EWC46955.1 - 4.9 6.1 11.4 7.2 5.5 7.9 1.3 1 0 0 1 1 1 0 TMPIT-like protein Glyco_tran_WecB PF03808.8 EWC46956.1 - 0.0033 16.8 1.9 0.0038 16.6 0.2 2.0 2 0 0 2 2 2 1 Glycosyl transferase WecB/TagA/CpsF family DUF3405 PF11885.3 EWC46957.1 - 3.9e-06 25.3 0.0 4.8e-06 25.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3405) DUF3405 PF11885.3 EWC46958.1 - 1.4e-11 43.3 0.1 2.4e-06 26.0 0.1 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF3405) Acyltransferase PF01553.16 EWC46959.1 - 2.8e-32 110.9 0.0 4.2e-32 110.3 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase CoA_binding_3 PF13727.1 EWC46959.1 - 0.095 12.5 4.2 0.046 13.5 1.2 1.6 2 0 0 2 2 2 0 CoA-binding domain ACPS PF01648.15 EWC46960.1 - 1.2e-05 25.1 0.0 2.2e-05 24.2 0.0 1.6 1 1 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily FAD_binding_6 PF00970.19 EWC46961.1 - 6.5e-31 106.3 0.0 9.5e-31 105.8 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.16 EWC46961.1 - 6.6e-27 94.2 0.0 1e-26 93.6 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.7 EWC46961.1 - 1.4e-06 28.3 0.0 0.00011 22.1 0.0 2.2 2 0 0 2 2 2 2 Ferric reductase NAD binding domain DUF3605 PF12239.3 EWC46962.1 - 4.5e-56 189.0 0.2 5.6e-56 188.7 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3605) Histone PF00125.19 EWC46963.1 - 1.6e-15 56.9 0.1 1.9e-15 56.6 0.1 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TAF PF02969.12 EWC46963.1 - 0.0001 22.1 0.1 0.00015 21.6 0.1 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-S PF15630.1 EWC46963.1 - 0.00012 22.1 0.1 0.00018 21.6 0.1 1.4 1 1 0 1 1 1 1 Kinetochore component CENP-S CBFD_NFYB_HMF PF00808.18 EWC46963.1 - 0.00017 21.5 0.1 0.0003 20.7 0.0 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.8 EWC46963.1 - 0.018 14.7 0.0 0.021 14.5 0.0 1.2 1 0 0 1 1 1 0 Bromodomain associated CENP-T PF15511.1 EWC46963.1 - 0.022 14.0 0.0 0.022 13.9 0.0 1.0 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T DUF788 PF05620.6 EWC46964.1 - 1.2e-41 142.4 0.0 1.4e-41 142.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF788) ACC_central PF08326.7 EWC46965.1 - 1.9e-248 826.2 0.0 2.3e-248 825.9 0.0 1.1 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region Carboxyl_trans PF01039.17 EWC46965.1 - 4.8e-180 599.1 0.0 6.3e-180 598.7 0.0 1.2 1 0 0 1 1 1 1 Carboxyl transferase domain CPSase_L_D2 PF02786.12 EWC46965.1 - 9.6e-52 175.3 0.0 1.7e-51 174.5 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_chain PF00289.17 EWC46965.1 - 1e-24 86.7 0.1 2e-24 85.8 0.1 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, N-terminal domain Biotin_carb_C PF02785.14 EWC46965.1 - 1.2e-19 70.2 0.0 9.7e-19 67.3 0.0 2.5 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.17 EWC46965.1 - 3.9e-16 58.4 0.5 1.1e-15 57.0 0.3 1.8 1 0 0 1 1 1 1 Biotin-requiring enzyme ATP-grasp_4 PF13535.1 EWC46965.1 - 1.5e-11 44.4 0.0 3.2e-11 43.2 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_Ter PF15632.1 EWC46965.1 - 2.2e-10 39.7 0.0 1.1e-07 30.9 0.0 3.1 1 1 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon Biotin_lipoyl_2 PF13533.1 EWC46965.1 - 0.00071 19.1 0.0 0.0021 17.6 0.0 1.8 1 0 0 1 1 1 1 Biotin-lipoyl like ATP-grasp_3 PF02655.9 EWC46965.1 - 0.00083 19.2 0.0 0.0031 17.4 0.0 2.0 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.8 EWC46965.1 - 0.00089 18.6 0.3 0.0048 16.2 0.0 2.4 3 0 0 3 3 3 1 D-ala D-ala ligase C-terminus RnfC_N PF13375.1 EWC46965.1 - 0.017 14.8 0.0 0.054 13.2 0.0 1.8 1 0 0 1 1 1 0 RnfC Barrel sandwich hybrid domain ATP-grasp PF02222.17 EWC46965.1 - 0.073 12.4 0.0 0.17 11.1 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp domain SRA1 PF07304.6 EWC46965.1 - 0.083 12.6 0.3 0.35 10.5 0.0 2.0 2 0 0 2 2 2 0 Steroid receptor RNA activator (SRA1) HlyD_2 PF12700.2 EWC46965.1 - 0.38 9.8 0.0 0.71 8.9 0.0 1.3 1 0 0 1 1 1 0 HlyD family secretion protein CITED PF04487.7 EWC46965.1 - 0.42 10.7 0.0 3.7 7.7 0.0 2.2 2 0 0 2 2 2 0 CITED RIO1 PF01163.17 EWC46966.1 - 9.7e-66 220.7 0.0 9.7e-66 220.7 0.0 1.6 2 0 0 2 2 2 1 RIO1 family APH PF01636.18 EWC46966.1 - 0.00098 18.9 0.8 1.5 8.4 0.0 3.0 3 0 0 3 3 3 2 Phosphotransferase enzyme family Kdo PF06293.9 EWC46966.1 - 0.0044 16.1 0.3 2.1 7.3 0.0 2.3 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family DUF3464 PF11947.3 EWC46966.1 - 0.068 12.6 6.6 0.018 14.5 1.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3464) SMC_N PF02463.14 EWC46967.1 - 1.2e-61 207.7 37.6 4e-61 206.0 26.1 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.8 EWC46967.1 - 1.1e-31 109.3 0.0 1.2e-30 105.9 0.0 2.9 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.1 EWC46967.1 - 4.2e-15 56.4 15.8 3e-10 40.5 0.2 3.9 3 1 0 3 3 3 2 AAA domain AAA_23 PF13476.1 EWC46967.1 - 1.3e-08 35.4 120.1 3.3e-06 27.5 36.7 6.7 3 2 0 3 3 2 1 AAA domain Reo_sigmaC PF04582.7 EWC46967.1 - 1.9e-06 27.3 34.1 0.00092 18.4 1.1 4.9 2 2 1 5 5 5 3 Reovirus sigma C capsid protein CENP-Q PF13094.1 EWC46967.1 - 8.8e-05 22.5 6.6 8.8e-05 22.5 4.6 7.5 2 2 4 6 6 4 1 CENP-Q, a CENPA-CAD centromere complex subunit AAA_29 PF13555.1 EWC46967.1 - 0.0003 20.2 0.0 0.00075 18.9 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain Filament PF00038.16 EWC46967.1 - 0.0022 17.4 35.8 0.0022 17.4 24.8 4.8 2 2 1 4 4 3 2 Intermediate filament protein HD_3 PF13023.1 EWC46967.1 - 0.0032 17.2 3.9 0.0032 17.2 2.7 5.3 2 2 4 6 6 6 1 HD domain AAA_13 PF13166.1 EWC46967.1 - 0.26 9.7 0.0 0.26 9.7 0.0 6.3 3 2 3 6 6 6 0 AAA domain FtsK_SpoIIIE PF01580.13 EWC46967.1 - 0.32 10.4 0.0 0.32 10.4 0.0 4.5 5 3 0 5 5 5 0 FtsK/SpoIIIE family DUF869 PF05911.6 EWC46967.1 - 4.4 5.4 90.4 0.3 9.2 26.1 3.2 2 1 1 3 3 3 0 Plant protein of unknown function (DUF869) TPR_1 PF00515.23 EWC46968.1 - 1.1e-40 135.6 22.3 4.4e-08 32.3 0.0 9.3 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_11 PF13414.1 EWC46968.1 - 2.1e-40 136.1 24.6 1.3e-11 43.9 0.6 7.5 5 3 2 7 7 7 6 TPR repeat TPR_2 PF07719.12 EWC46968.1 - 9.3e-36 118.8 26.9 4.5e-06 26.1 0.0 10.3 11 0 0 11 11 11 7 Tetratricopeptide repeat TPR_8 PF13181.1 EWC46968.1 - 1.5e-28 96.3 2.4 0.00023 20.7 0.1 8.8 9 0 0 9 9 9 6 Tetratricopeptide repeat Apc3 PF12895.2 EWC46968.1 - 1.6e-26 92.2 22.0 2.1e-17 63.0 0.5 5.2 4 1 1 5 5 5 5 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.1 EWC46968.1 - 3.3e-19 68.6 21.9 2e-05 24.4 0.6 7.3 4 3 3 7 7 7 5 Tetratricopeptide repeat TPR_16 PF13432.1 EWC46968.1 - 1.9e-18 66.6 13.1 0.0002 21.9 0.0 8.1 7 1 1 8 8 8 3 Tetratricopeptide repeat TPR_19 PF14559.1 EWC46968.1 - 3.4e-18 65.7 9.2 1.7e-05 25.0 0.0 7.5 6 2 1 7 7 7 3 Tetratricopeptide repeat TPR_14 PF13428.1 EWC46968.1 - 9.3e-18 63.1 5.1 0.42 11.3 0.0 9.2 5 1 3 9 9 9 5 Tetratricopeptide repeat TPR_17 PF13431.1 EWC46968.1 - 4.6e-16 57.5 7.6 0.42 10.9 0.0 8.8 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_7 PF13176.1 EWC46968.1 - 2.1e-12 45.8 8.3 0.00096 18.7 0.1 7.7 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_6 PF13174.1 EWC46968.1 - 2.8e-08 33.6 9.7 1.3 9.6 0.1 8.0 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_9 PF13371.1 EWC46968.1 - 0.00077 19.2 4.0 13 5.7 0.0 5.6 3 1 3 7 7 7 0 Tetratricopeptide repeat TPR_15 PF13429.1 EWC46968.1 - 0.0013 17.8 6.3 0.23 10.4 0.3 4.3 3 1 1 4 4 4 2 Tetratricopeptide repeat MIT PF04212.13 EWC46968.1 - 0.0043 16.8 6.2 0.7 9.8 0.2 4.8 4 1 1 5 5 5 1 MIT (microtubule interacting and transport) domain Sel1 PF08238.7 EWC46968.1 - 0.0063 17.1 5.2 1.9 9.2 0.0 4.8 4 0 0 4 4 4 1 Sel1 repeat TPR_10 PF13374.1 EWC46968.1 - 0.066 13.1 1.5 4.6 7.3 0.0 4.4 5 0 0 5 5 4 0 Tetratricopeptide repeat BTAD PF03704.12 EWC46968.1 - 0.67 10.2 8.6 0.12 12.6 0.5 3.4 3 2 1 4 4 3 0 Bacterial transcriptional activator domain Peptidase_M48 PF01435.13 EWC46969.1 - 7.9e-38 130.2 0.0 1.4e-37 129.4 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M48 Mito_carr PF00153.22 EWC46970.1 - 8.4e-45 150.4 2.4 1.8e-15 56.4 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Kinesin PF00225.18 EWC46971.1 - 3.3e-102 341.6 0.2 6.1e-102 340.7 0.1 1.5 1 0 0 1 1 1 1 Kinesin motor domain Filament PF00038.16 EWC46971.1 - 0.00022 20.7 9.3 0.00022 20.7 6.5 3.0 1 1 2 3 3 3 2 Intermediate filament protein Ribosomal_60s PF00428.14 EWC46971.1 - 0.13 12.6 13.1 0.047 14.0 5.9 2.8 2 0 0 2 2 2 0 60s Acidic ribosomal protein Apolipoprotein PF01442.13 EWC46971.1 - 2.3 7.6 38.3 0.7 9.3 14.1 2.4 1 1 1 2 2 2 0 Apolipoprotein A1/A4/E domain zf-C3HC4_2 PF13923.1 EWC46972.1 - 5.1e-10 39.2 14.8 1.1e-05 25.3 2.7 3.0 2 1 1 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EWC46972.1 - 6.5e-06 25.7 5.0 6.5e-06 25.7 3.5 2.5 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.1 EWC46972.1 - 1.7e-05 24.5 15.8 0.007 16.1 3.6 2.9 2 1 1 3 3 3 2 Ring finger domain zf-C3HC4_3 PF13920.1 EWC46972.1 - 3e-05 23.6 15.9 0.00022 20.8 3.1 2.6 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) Rtf2 PF04641.7 EWC46972.1 - 4.6e-05 22.7 2.3 4.6e-05 22.7 1.6 3.4 2 2 1 3 3 3 2 Rtf2 RING-finger zf-RING_UBOX PF13445.1 EWC46972.1 - 0.00016 21.3 6.1 0.00028 20.5 2.8 2.5 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.20 EWC46972.1 - 0.00061 19.3 2.6 0.00061 19.3 1.8 3.0 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) DUF572 PF04502.8 EWC46972.1 - 0.0025 17.1 5.4 0.0044 16.2 3.7 1.4 1 0 0 1 1 1 1 Family of unknown function (DUF572) OmpH PF03938.9 EWC46972.1 - 0.0028 17.6 4.9 0.0039 17.1 3.4 1.2 1 0 0 1 1 1 1 Outer membrane protein (OmpH-like) FYVE PF01363.16 EWC46972.1 - 0.019 14.8 3.1 0.019 14.8 2.1 2.8 2 2 0 2 2 2 0 FYVE zinc finger OEP PF02321.13 EWC46972.1 - 0.066 12.7 3.5 5.4 6.5 0.0 2.4 3 0 0 3 3 3 0 Outer membrane efflux protein zf-RING_6 PF14835.1 EWC46972.1 - 1.4 8.7 12.8 0.92 9.3 1.6 2.7 3 0 0 3 3 2 0 zf-RING of BARD1-type protein Vps39_2 PF10367.4 EWC46972.1 - 2.4 8.3 8.6 0.98 9.6 1.7 2.8 3 0 0 3 3 2 0 Vacuolar sorting protein 39 domain 2 TBCA PF02970.11 EWC46972.1 - 3.4 7.8 9.5 0.62 10.1 1.0 2.6 1 1 1 2 2 2 0 Tubulin binding cofactor A CBFD_NFYB_HMF PF00808.18 EWC46973.1 - 1.7e-16 60.0 0.7 3.8e-16 58.9 0.5 1.6 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 EWC46973.1 - 6.2e-08 32.6 0.3 1.3e-07 31.6 0.2 1.4 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Tox-MPTase2 PF15638.1 EWC46973.1 - 0.15 11.5 1.2 0.25 10.8 0.8 1.2 1 0 0 1 1 1 0 Metallopeptidase toxin 2 Glyco_transf_34 PF05637.7 EWC46974.1 - 1.1e-66 224.7 0.0 1.6e-66 224.2 0.0 1.2 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family Mito_fiss_reg PF05308.6 EWC46974.1 - 0.029 13.7 14.5 0.048 13.0 10.1 1.4 1 0 0 1 1 1 0 Mitochondrial fission regulator Ycf1 PF05758.7 EWC46974.1 - 0.035 11.8 0.1 0.037 11.7 0.0 1.0 1 0 0 1 1 1 0 Ycf1 PAT1 PF09770.4 EWC46974.1 - 0.47 8.6 32.5 0.59 8.3 22.5 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CAP_N PF01213.14 EWC46974.1 - 1.2 8.3 14.1 1.8 7.7 9.7 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Hid1 PF12722.2 EWC46974.1 - 2 5.9 4.7 2.5 5.6 3.3 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RR_TM4-6 PF06459.7 EWC46974.1 - 3 7.6 9.9 4.3 7.1 6.9 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Suf PF05843.9 EWC46974.1 - 8.4 6.0 11.5 12 5.5 7.9 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Pkinase PF00069.20 EWC46975.1 - 7.5e-49 166.2 0.0 1e-48 165.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC46975.1 - 1.9e-25 89.4 0.0 2.8e-25 88.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EWC46975.1 - 0.0013 17.7 0.1 0.0076 15.2 0.0 2.0 1 1 0 1 1 1 1 Kinase-like CTD_bind PF04818.8 EWC46976.1 - 1.7e-20 73.0 0.1 4e-20 71.8 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase II-binding domain. DUF3508 PF12018.3 EWC46976.1 - 0.016 14.1 0.2 0.028 13.4 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3508) Clathrin_lg_ch PF01086.12 EWC46977.1 - 2.4e-66 223.9 0.4 2.6e-66 223.7 0.3 1.0 1 0 0 1 1 1 1 Clathrin light chain rve_3 PF13683.1 EWC46977.1 - 0.091 12.2 0.2 0.23 10.9 0.1 1.7 1 1 0 1 1 1 0 Integrase core domain EF-hand_8 PF13833.1 EWC46978.1 - 9.6e-36 121.1 4.3 8.6e-16 57.3 0.2 3.1 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.27 EWC46978.1 - 2.6e-33 110.7 7.2 1.1e-09 36.8 0.6 4.1 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.1 EWC46978.1 - 1.3e-30 105.2 1.7 4.2e-20 71.6 0.6 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 EWC46978.1 - 9.4e-23 78.0 4.0 5.4e-09 35.1 0.0 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.1 EWC46978.1 - 2.6e-19 67.6 2.9 1.4e-05 24.1 0.0 4.1 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.1 EWC46978.1 - 4.8e-13 48.8 0.2 1.7e-05 24.6 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain UPF0154 PF03672.8 EWC46978.1 - 3.1e-08 33.1 0.3 0.025 14.1 0.0 3.2 2 1 1 3 3 3 2 Uncharacterised protein family (UPF0154) EF-hand_4 PF12763.2 EWC46978.1 - 9.3e-08 31.7 0.8 0.0012 18.5 0.1 2.1 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand EFhand_Ca_insen PF08726.5 EWC46978.1 - 3.3e-07 30.1 0.5 1.1e-06 28.5 0.2 1.9 2 0 0 2 2 2 1 Ca2+ insensitive EF hand SPARC_Ca_bdg PF10591.4 EWC46978.1 - 3.5e-06 27.0 0.0 0.0011 18.9 0.0 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region TerB PF05099.8 EWC46978.1 - 0.0018 18.0 0.2 1.6 8.4 0.0 2.1 1 1 1 2 2 2 2 Tellurite resistance protein TerB Tenui_NCP PF04876.7 EWC46978.1 - 0.0026 17.3 0.1 0.17 11.4 0.0 2.2 1 1 1 2 2 2 1 Tenuivirus major non-capsid protein RNA_pol_Rpb4 PF03874.11 EWC46978.1 - 0.019 14.9 1.3 5.8 6.9 0.1 2.5 3 0 0 3 3 3 0 RNA polymerase Rpb4 DUF1103 PF06513.6 EWC46978.1 - 0.041 13.2 0.6 0.054 12.8 0.4 1.1 1 0 0 1 1 1 0 Repeat of unknown function (DUF1103) Peptidase_M24 PF00557.19 EWC46978.1 - 0.12 11.8 0.0 7.2 6.1 0.0 2.3 1 1 2 3 3 3 0 Metallopeptidase family M24 EF-hand_10 PF14788.1 EWC46978.1 - 0.14 11.7 0.8 1.1 8.9 0.0 2.6 1 1 2 3 3 3 0 EF hand ABC_membrane PF00664.18 EWC46979.1 - 1.1e-53 182.4 8.5 1.4e-53 182.0 5.9 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.22 EWC46979.1 - 6.8e-26 91.2 0.0 2.2e-25 89.5 0.0 2.0 2 0 0 2 2 2 1 ABC transporter AAA_25 PF13481.1 EWC46979.1 - 0.0086 15.4 0.3 0.038 13.3 0.2 2.0 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.1 EWC46979.1 - 0.01 15.9 0.0 0.047 13.8 0.0 2.1 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.1 EWC46979.1 - 0.012 15.0 0.1 0.032 13.7 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.1 EWC46979.1 - 0.03 14.2 1.2 0.18 11.7 0.8 2.2 1 1 0 1 1 1 0 AAA ATPase domain AAA_17 PF13207.1 EWC46979.1 - 0.038 14.8 0.0 0.087 13.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_21 PF13304.1 EWC46979.1 - 0.046 13.6 0.8 6 6.7 0.2 2.5 2 1 0 3 3 3 0 AAA domain SMC_N PF02463.14 EWC46979.1 - 0.079 12.1 1.4 1.4 8.1 0.0 2.3 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain CDC37_N PF03234.9 EWC46980.1 - 1.3e-46 159.1 6.8 1.3e-46 159.1 4.7 2.5 2 1 0 2 2 2 1 Cdc37 N terminal kinase binding CDC37_M PF08565.6 EWC46980.1 - 1.3e-37 128.9 0.0 1.3e-37 128.9 0.0 1.8 2 0 0 2 2 2 1 Cdc37 Hsp90 binding domain CDC37_C PF08564.5 EWC46980.1 - 6.1e-26 90.1 2.8 6.1e-26 90.1 1.9 3.2 3 0 0 3 3 3 1 Cdc37 C terminal domain TAF1D PF15333.1 EWC46980.1 - 0.0056 16.4 0.2 0.022 14.5 0.2 2.0 1 0 0 1 1 1 1 TATA box-binding protein-associated factor 1D Nucleoside_tran PF01733.13 EWC46981.1 - 4.2e-45 154.2 6.3 4.2e-45 154.2 4.4 2.1 1 1 0 2 2 2 1 Nucleoside transporter PI3_PI4_kinase PF00454.22 EWC46982.1 - 5.2e-31 107.9 0.0 9.4e-31 107.0 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase Pik1 PF11522.3 EWC46982.1 - 2.3e-14 52.8 0.0 5.9e-14 51.5 0.0 1.8 1 0 0 1 1 1 1 Yeast phosphatidylinositol-4-OH kinase Pik1 PI3Ka PF00613.15 EWC46982.1 - 0.0022 17.2 0.4 0.0043 16.2 0.3 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF4135 PF13575.1 EWC46982.1 - 0.026 13.5 0.0 0.046 12.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) DUF2424 PF10340.4 EWC46983.1 - 1.2e-26 93.2 0.0 1.4e-26 93.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2424) Abhydrolase_3 PF07859.8 EWC46983.1 - 8.9e-24 84.2 0.0 1.1e-23 83.8 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF1375 PF07119.7 EWC46983.1 - 0.017 14.9 0.1 0.035 13.9 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1375) zf-RING_6 PF14835.1 EWC46984.1 - 0.0021 17.7 7.1 0.0032 17.1 4.9 1.3 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-C3HC4_3 PF13920.1 EWC46984.1 - 0.4 10.3 11.3 0.66 9.6 7.8 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Velvet PF11754.3 EWC46985.1 - 4.1e-58 196.3 0.0 6.8e-58 195.6 0.0 1.3 1 0 0 1 1 1 1 Velvet factor SnAC PF14619.1 EWC46985.1 - 0.88 9.7 7.1 0.67 10.1 2.7 2.4 2 0 0 2 2 2 0 Snf2-ATP coupling, chromatin remodelling complex ILVD_EDD PF00920.16 EWC46986.1 - 1.3e-195 650.7 0.4 1.5e-195 650.5 0.3 1.0 1 0 0 1 1 1 1 Dehydratase family 5_nucleotid_C PF02872.13 EWC46986.1 - 0.011 15.7 0.0 0.14 12.1 0.0 2.5 3 0 0 3 3 3 0 5'-nucleotidase, C-terminal domain FrhB_FdhB_N PF04422.8 EWC46986.1 - 0.081 12.7 1.7 0.22 11.4 0.0 2.6 3 1 0 3 3 3 0 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term RAI16-like PF10257.4 EWC46987.1 - 2.9e-75 253.4 0.3 4.8e-75 252.7 0.2 1.3 1 0 0 1 1 1 1 Retinoic acid induced 16-like protein Med20 PF08612.6 EWC46988.1 - 1.1e-32 112.9 0.0 2.9e-24 85.4 0.0 2.1 1 1 1 2 2 2 2 TATA-binding related factor (TRF) of subunit 20 of Mediator complex FAP PF07174.6 EWC46988.1 - 0.17 11.1 8.1 0.22 10.7 5.6 1.1 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) MBD_C PF14048.1 EWC46988.1 - 0.23 12.0 0.7 0.53 10.9 0.5 1.6 1 0 0 1 1 1 0 C-terminal domain of methyl-CpG binding protein 2 and 3 FAD_binding_1 PF00667.15 EWC46989.1 - 9.9e-50 169.0 0.0 3.4e-49 167.2 0.0 1.7 2 0 0 2 2 2 1 FAD binding domain NAD_binding_1 PF00175.16 EWC46989.1 - 4e-10 40.2 0.0 2.4e-09 37.7 0.0 2.3 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain PAP_PilO PF06864.7 EWC46990.1 - 0.008 14.5 0.1 0.012 14.0 0.1 1.2 1 0 0 1 1 1 1 Pilin accessory protein (PilO) Acyltransferase PF01553.16 EWC46991.1 - 0.0028 17.0 0.0 0.0069 15.8 0.0 1.6 1 1 0 1 1 1 1 Acyltransferase CBM_21 PF03370.8 EWC46992.1 - 7.7e-35 119.2 2.3 1.6e-34 118.2 1.6 1.5 1 0 0 1 1 1 1 Putative phosphatase regulatory subunit BolA PF01722.13 EWC46993.1 - 8.4e-13 48.0 0.0 1.3e-12 47.4 0.0 1.2 1 0 0 1 1 1 1 BolA-like protein DUF3438 PF11920.3 EWC46993.1 - 0.097 11.5 0.0 0.11 11.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3438) DEAD PF00270.24 EWC46994.1 - 5.5e-40 136.6 0.1 1e-39 135.7 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EWC46994.1 - 6.7e-23 80.3 0.0 2e-11 43.5 0.0 2.6 2 0 0 2 2 2 2 Helicase conserved C-terminal domain ResIII PF04851.10 EWC46994.1 - 0.00028 20.7 0.2 0.0028 17.5 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit CDC45 PF02724.9 EWC46994.1 - 0.0057 14.7 0.1 0.0077 14.3 0.1 1.2 1 0 0 1 1 1 1 CDC45-like protein TLP-20 PF06088.6 EWC46994.1 - 0.033 13.8 0.4 0.066 12.8 0.3 1.5 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) TSGP1 PF07771.6 EWC46994.1 - 2.1 8.2 8.4 3.9 7.3 5.9 1.4 1 0 0 1 1 1 0 Tick salivary peptide group 1 YEATS PF03366.11 EWC46995.1 - 1.2e-33 114.6 0.5 2.1e-33 113.8 0.3 1.4 1 0 0 1 1 1 1 YEATS family WD40 PF00400.27 EWC46996.1 - 2.5e-57 188.8 14.1 1.4e-10 40.6 0.4 8.5 8 0 0 8 8 8 7 WD domain, G-beta repeat F-box-like PF12937.2 EWC46996.1 - 1.6e-14 53.3 1.8 3.3e-14 52.3 0.4 2.3 2 0 0 2 2 2 1 F-box-like F-box PF00646.28 EWC46996.1 - 2e-11 43.2 0.3 6.7e-11 41.5 0.2 2.0 1 0 0 1 1 1 1 F-box domain Nup160 PF11715.3 EWC46996.1 - 5.9e-11 41.1 17.1 0.00049 18.3 0.2 5.7 2 2 4 6 6 6 5 Nucleoporin Nup120/160 Pyr_redox_2 PF07992.9 EWC46996.1 - 0.009 15.9 0.0 0.011 15.5 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Herpes_Helicase PF02689.9 EWC46996.1 - 0.051 11.3 0.0 0.069 10.8 0.0 1.1 1 0 0 1 1 1 0 Helicase Nucleoporin_N PF08801.6 EWC46996.1 - 0.24 10.0 1.3 11 4.6 0.0 2.7 2 1 0 2 2 2 0 Nup133 N terminal like APG17 PF04108.7 EWC46997.1 - 3.5e-84 282.9 4.7 6e-84 282.2 3.3 1.4 1 0 0 1 1 1 1 Autophagy protein Apg17 Fib_alpha PF08702.5 EWC46997.1 - 0.056 13.5 5.7 1.9 8.6 0.6 2.6 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family GLE1 PF07817.8 EWC46997.1 - 0.075 11.9 0.2 0.46 9.3 0.1 2.3 3 0 0 3 3 3 0 GLE1-like protein ING PF12998.2 EWC46997.1 - 0.078 13.2 3.0 1.5 9.1 0.0 3.3 2 1 1 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding PXA PF02194.10 EWC46997.1 - 0.14 11.6 5.4 0.29 10.6 0.1 3.5 3 1 1 4 4 4 0 PXA domain Prominin PF05478.6 EWC46997.1 - 0.17 9.3 1.4 0.29 8.6 1.0 1.3 1 0 0 1 1 1 0 Prominin IFT20 PF14931.1 EWC46997.1 - 0.24 11.3 5.1 14 5.6 0.0 3.7 3 0 0 3 3 3 0 Intraflagellar transport complex B, subunit 20 DUF4559 PF15112.1 EWC46997.1 - 0.83 8.7 7.7 0.58 9.2 1.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4559) NAD_binding_10 PF13460.1 EWC46998.1 - 6.6e-10 39.2 0.0 1e-09 38.6 0.0 1.4 1 1 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 EWC46998.1 - 8.3e-05 22.1 0.0 0.0001 21.7 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 EWC46998.1 - 0.0034 16.1 0.0 0.0043 15.7 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NmrA PF05368.8 EWC46998.1 - 0.049 12.8 0.0 0.063 12.5 0.0 1.2 1 0 0 1 1 1 0 NmrA-like family SYF2 PF08231.7 EWC46999.1 - 1.6e-45 154.9 15.6 1.6e-45 154.9 10.8 1.9 2 0 0 2 2 2 1 SYF2 splicing factor DUF1900 PF08954.6 EWC47000.1 - 1.2e-51 173.7 0.0 2e-50 169.8 0.0 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF1900) DUF1899 PF08953.6 EWC47000.1 - 2.5e-35 119.9 0.1 4.2e-35 119.1 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40 PF00400.27 EWC47000.1 - 1.7e-22 78.3 4.7 2.8e-07 30.1 0.0 4.3 4 0 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.3 EWC47000.1 - 0.0033 15.6 0.4 0.72 7.9 0.0 2.2 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Hat1_N PF10394.4 EWC47001.1 - 6e-23 81.6 0.0 1.2e-22 80.6 0.0 1.5 1 0 0 1 1 1 1 Histone acetyl transferase HAT1 N-terminus Acetyltransf_1 PF00583.19 EWC47001.1 - 0.00021 21.2 0.0 0.00047 20.1 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 EWC47001.1 - 0.0011 19.0 0.0 0.0061 16.6 0.0 2.2 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 EWC47001.1 - 0.0017 18.4 0.0 0.004 17.2 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain CTP_synth_N PF06418.9 EWC47002.1 - 3.2e-82 275.7 0.0 4.4e-82 275.2 0.0 1.1 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.23 EWC47002.1 - 2.8e-56 190.0 0.0 4.6e-56 189.3 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 EWC47002.1 - 2e-07 30.7 0.0 4.4e-07 29.5 0.0 1.6 1 0 0 1 1 1 1 Peptidase C26 TPR_2 PF07719.12 EWC47003.1 - 0.00029 20.5 1.5 0.4 10.7 0.1 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.23 EWC47003.1 - 0.0017 17.8 0.3 2.4 7.8 0.0 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.1 EWC47003.1 - 0.0084 15.8 0.1 5.9 6.9 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.1 EWC47003.1 - 0.021 14.4 5.6 1.3 8.6 0.7 2.7 2 0 0 2 2 2 0 TPR repeat TPR_16 PF13432.1 EWC47003.1 - 0.026 15.2 11.4 0.05 14.2 0.8 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat Sel1 PF08238.7 EWC47003.1 - 0.075 13.6 4.8 1.1 10.0 0.0 3.7 3 1 0 3 3 3 0 Sel1 repeat TPR_12 PF13424.1 EWC47003.1 - 0.13 12.2 2.5 3.7 7.5 0.2 2.9 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.1 EWC47003.1 - 1.3 9.9 4.8 44 5.0 0.1 3.9 2 1 1 3 3 3 0 Tetratricopeptide repeat HMG_box PF00505.14 EWC47004.1 - 3.3e-12 46.5 0.3 7e-12 45.4 0.2 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 EWC47004.1 - 2.3e-07 31.0 1.1 4.3e-07 30.2 0.8 1.4 1 0 0 1 1 1 1 HMG-box domain Zip PF02535.17 EWC47005.1 - 1.8e-34 119.1 15.3 1.8e-24 86.3 6.5 2.3 1 1 1 2 2 2 2 ZIP Zinc transporter DUF2231 PF09990.4 EWC47005.1 - 6 7.2 12.2 0.45 10.8 0.5 3.1 3 0 0 3 3 3 0 Predicted membrane protein (DUF2231) Cpn60_TCP1 PF00118.19 EWC47006.1 - 1.7e-135 452.3 4.6 1.9e-135 452.2 3.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Alg6_Alg8 PF03155.10 EWC47007.1 - 4.9e-143 477.3 26.4 6e-143 477.0 18.3 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family PH_10 PF15411.1 EWC47008.1 - 2.5e-27 95.3 0.0 4.7e-27 94.4 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain zf-RING_2 PF13639.1 EWC47008.1 - 3.3e-07 30.0 6.3 6.6e-07 29.0 4.3 1.5 1 0 0 1 1 1 1 Ring finger domain VWA_3 PF13768.1 EWC47008.1 - 4.3e-07 29.7 0.1 2.9e-06 27.0 0.0 2.3 2 1 0 2 2 2 1 von Willebrand factor type A domain VWA PF00092.23 EWC47008.1 - 1.8e-05 24.5 0.0 3.3e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain PH PF00169.24 EWC47008.1 - 0.00059 20.0 0.1 0.0019 18.3 0.1 1.8 1 0 0 1 1 1 1 PH domain zf-C3HC4_3 PF13920.1 EWC47008.1 - 0.0011 18.5 2.2 0.002 17.7 1.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EWC47008.1 - 0.0014 18.2 5.1 0.0025 17.4 3.5 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 EWC47008.1 - 0.0089 16.0 4.7 0.017 15.1 3.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 EWC47008.1 - 0.022 14.8 2.2 0.05 13.7 1.6 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger zf-RING-like PF08746.6 EWC47008.1 - 0.039 13.9 6.0 0.074 13.0 4.1 1.5 1 0 0 1 1 1 0 RING-like domain zf-C3HC4 PF00097.20 EWC47008.1 - 0.054 13.1 5.1 0.1 12.2 3.6 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 EWC47008.1 - 0.11 12.3 0.2 0.24 11.2 0.2 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger WAC_Acf1_DNA_bd PF10537.4 EWC47009.1 - 1.8e-36 124.3 0.0 4.5e-36 123.0 0.0 1.7 1 0 0 1 1 1 1 ATP-utilising chromatin assembly and remodelling N-terminal DDT PF02791.12 EWC47009.1 - 1.4e-15 56.8 1.9 2.4e-15 56.0 1.3 1.4 1 0 0 1 1 1 1 DDT domain WHIM2 PF15613.1 EWC47009.1 - 8.5e-09 34.9 2.4 1.1e-08 34.6 0.6 2.0 2 0 0 2 2 2 1 WSTF, HB1, Itc1p, MBD9 motif 2 WHIM3 PF15614.1 EWC47009.1 - 0.0017 18.0 3.6 0.0039 16.9 0.7 2.4 2 0 0 2 2 2 1 WSTF, HB1, Itc1p, MBD9 motif 3 WHIM1 PF15612.1 EWC47009.1 - 0.033 14.1 0.2 0.24 11.4 0.0 2.4 2 0 0 2 2 2 0 WSTF, HB1, Itc1p, MBD9 motif 1 OSTbeta PF15048.1 EWC47009.1 - 3 7.9 8.2 1 9.4 2.3 2.3 2 0 0 2 2 2 0 Organic solute transporter subunit beta protein RhoGAP PF00620.22 EWC47010.1 - 1.1e-32 112.7 0.0 2.2e-32 111.7 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain RasGEF PF00617.14 EWC47010.1 - 1.4e-17 64.0 0.0 4.1e-17 62.5 0.0 1.8 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.15 EWC47010.1 - 1.4e-12 47.5 0.0 7.9e-12 45.2 0.0 2.3 2 1 0 2 2 2 1 RasGEF N-terminal motif PH_9 PF15410.1 EWC47010.1 - 1.7e-06 28.2 0.0 0.00043 20.4 0.0 2.6 2 0 0 2 2 2 2 Pleckstrin homology domain PH PF00169.24 EWC47010.1 - 0.00047 20.3 0.0 1.3 9.2 0.0 2.7 2 0 0 2 2 2 2 PH domain WD40 PF00400.27 EWC47011.1 - 3.1e-55 182.1 22.8 1.5e-10 40.5 0.2 7.4 7 0 0 7 7 7 6 WD domain, G-beta repeat F-box-like PF12937.2 EWC47011.1 - 1.5e-12 47.0 0.3 3.1e-12 46.0 0.2 1.6 1 0 0 1 1 1 1 F-box-like Nup160 PF11715.3 EWC47011.1 - 6.8e-09 34.4 12.1 0.25 9.4 0.1 6.1 1 1 4 5 5 5 5 Nucleoporin Nup120/160 F-box PF00646.28 EWC47011.1 - 0.00026 20.5 0.2 0.00062 19.3 0.2 1.7 1 0 0 1 1 1 1 F-box domain Nucleoporin_N PF08801.6 EWC47011.1 - 0.0013 17.5 0.5 0.03 13.0 0.0 2.3 1 1 1 2 2 2 1 Nup133 N terminal like DUF155 PF02582.9 EWC47012.1 - 7.6e-57 192.0 1.1 7.6e-57 192.0 0.8 1.6 2 0 0 2 2 2 1 Uncharacterised ACR, YagE family COG1723 UPF0449 PF15136.1 EWC47012.1 - 0.053 13.7 0.0 0.14 12.3 0.0 1.7 1 0 0 1 1 1 0 Uncharacterised protein family UPF0449 E1_dh PF00676.15 EWC47013.1 - 2.3e-114 381.1 0.2 2.7e-114 380.9 0.1 1.0 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.1 EWC47013.1 - 0.0011 18.0 0.0 0.0017 17.3 0.0 1.3 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase TPP_enzyme_C PF02775.16 EWC47013.1 - 0.015 14.8 1.5 0.03 13.8 1.0 1.5 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain WD40 PF00400.27 EWC47014.1 - 1.3e-59 196.0 10.1 1.9e-10 40.1 0.0 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat eIF2A PF08662.6 EWC47014.1 - 1.1e-05 25.2 0.0 0.048 13.3 0.0 2.5 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Epimerase PF01370.16 EWC47015.1 - 3.3e-41 141.2 0.0 4.8e-41 140.7 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 EWC47015.1 - 2.6e-11 42.9 0.0 3.7e-11 42.4 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.14 EWC47015.1 - 1.5e-10 40.2 0.0 2.2e-10 39.7 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.7 EWC47015.1 - 9.4e-09 34.5 0.0 5.1e-06 25.6 0.0 2.3 2 0 0 2 2 2 2 Male sterility protein Polysacc_synt_2 PF02719.10 EWC47015.1 - 1.6e-06 27.2 0.0 0.015 14.1 0.0 2.7 2 1 0 2 2 2 2 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.1 EWC47015.1 - 0.0041 17.1 0.0 0.0069 16.4 0.0 1.5 1 0 0 1 1 1 1 NADH(P)-binding Motile_Sperm PF00635.21 EWC47016.1 - 1e-23 83.0 0.0 2.2e-23 81.9 0.0 1.6 1 0 0 1 1 1 1 MSP (Major sperm protein) domain ATG_C PF09333.6 EWC47016.1 - 0.018 15.2 0.3 0.04 14.0 0.2 1.6 1 0 0 1 1 1 0 ATG C terminal domain DUF3984 PF13136.1 EWC47017.1 - 4.1e-40 137.9 39.6 1.4e-33 116.4 16.5 2.4 2 1 1 3 3 3 2 Protein of unknown function (DUF3984) Cut8_C PF08559.5 EWC47018.1 - 7.5e-48 161.9 0.0 1.1e-47 161.4 0.0 1.3 1 0 0 1 1 1 1 Cut8 six-helix bundle Cut8_M PF14483.1 EWC47018.1 - 0.0001 22.0 0.3 0.00025 20.7 0.2 1.7 1 0 0 1 1 1 1 Cut8 dimerisation domain Cut8_N PF14482.1 EWC47018.1 - 0.00075 19.4 6.1 0.0015 18.4 4.2 1.6 1 0 0 1 1 1 1 Cut8 proteasome-binding domain Stig1 PF04885.8 EWC47019.1 - 1.3e-06 28.6 21.3 1.3e-06 28.6 14.8 4.0 2 1 2 4 4 4 1 Stigma-specific protein, Stig1 PNTB PF02233.11 EWC47020.1 - 2.3e-168 560.7 24.7 3.9e-168 560.0 17.1 1.4 1 0 0 1 1 1 1 NAD(P) transhydrogenase beta subunit AlaDh_PNT_C PF01262.16 EWC47020.1 - 1.3e-54 184.2 0.5 2.5e-54 183.3 0.3 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain AlaDh_PNT_N PF05222.10 EWC47020.1 - 6.6e-45 152.4 0.0 1.6e-44 151.2 0.0 1.7 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain DUF3814 PF12769.2 EWC47020.1 - 2.8e-30 104.3 2.4 2.8e-30 104.3 1.7 4.4 2 1 1 4 4 4 1 Domain of unknown function (DUF3814) Methyltransf_18 PF12847.2 EWC47020.1 - 0.00081 19.9 0.0 0.0028 18.2 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain CP_ATPgrasp_1 PF04174.8 EWC47020.1 - 0.0016 17.1 0.0 0.0031 16.1 0.0 1.4 1 0 0 1 1 1 1 A circularly permuted ATPgrasp 2-Hacid_dh_C PF02826.14 EWC47020.1 - 0.0017 17.5 0.1 0.92 8.6 0.0 2.8 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TPP_enzyme_M PF00205.17 EWC47020.1 - 0.013 15.2 0.7 0.064 13.0 0.1 2.5 2 1 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain Pyr_redox_2 PF07992.9 EWC47020.1 - 0.046 13.5 1.2 0.11 12.3 0.3 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 EWC47020.1 - 0.048 12.5 0.5 0.082 11.7 0.4 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A Methyltransf_31 PF13847.1 EWC47020.1 - 0.19 11.3 0.0 0.44 10.1 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Voltage_CLC PF00654.15 EWC47021.1 - 4.4e-90 302.2 26.5 4.4e-90 302.2 18.4 1.9 2 0 0 2 2 2 1 Voltage gated chloride channel eIF-5_eIF-2B PF01873.12 EWC47022.1 - 1.7e-38 131.0 0.0 2.7e-38 130.4 0.0 1.3 1 0 0 1 1 1 1 Domain found in IF2B/IF5 W2 PF02020.13 EWC47022.1 - 2.1e-26 91.6 0.1 2.1e-26 91.6 0.0 3.4 4 0 0 4 4 4 1 eIF4-gamma/eIF5/eIF2-epsilon AAA_5 PF07728.9 EWC47023.1 - 2.5e-130 429.0 0.0 3e-20 72.3 0.0 9.7 9 0 0 9 9 9 9 AAA domain (dynein-related subfamily) AAA_3 PF07726.6 EWC47023.1 - 2e-34 118.0 0.0 1.6e-10 40.6 0.0 8.3 8 0 0 8 8 8 4 ATPase family associated with various cellular activities (AAA) AAA PF00004.24 EWC47023.1 - 3.9e-28 98.2 0.2 7.3e-05 22.9 0.0 6.9 6 0 0 6 6 6 5 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 EWC47023.1 - 1.6e-22 80.3 10.6 0.0006 19.8 0.1 8.0 7 1 0 7 7 6 5 AAA ATPase domain AAA_33 PF13671.1 EWC47023.1 - 3.1e-22 79.0 1.5 0.00056 19.8 0.0 8.0 6 2 0 6 6 6 5 AAA domain AAA_22 PF13401.1 EWC47023.1 - 1.2e-21 77.1 1.2 0.007 16.5 0.0 8.3 7 1 0 7 7 7 4 AAA domain AAA_17 PF13207.1 EWC47023.1 - 1.3e-21 77.6 2.8 0.066 14.0 0.0 8.1 7 0 0 7 7 6 5 AAA domain Sigma54_activat PF00158.21 EWC47023.1 - 2.6e-19 69.3 0.0 0.0058 16.1 0.0 6.1 6 0 0 6 6 6 5 Sigma-54 interaction domain Sigma54_activ_2 PF14532.1 EWC47023.1 - 3.2e-19 69.3 0.4 9.9e-06 25.6 0.0 6.7 7 0 0 7 7 6 3 Sigma-54 interaction domain ABC_tran PF00005.22 EWC47023.1 - 1.2e-17 64.4 0.7 0.0055 17.0 0.0 7.4 7 1 0 7 7 6 2 ABC transporter T2SE PF00437.15 EWC47023.1 - 2.2e-16 59.6 0.1 0.0055 15.6 0.0 6.4 6 0 0 6 6 6 3 Type II/IV secretion system protein AAA_14 PF13173.1 EWC47023.1 - 2.5e-15 56.4 0.0 0.00042 20.2 0.0 7.7 7 0 0 7 7 7 1 AAA domain AAA_18 PF13238.1 EWC47023.1 - 3.1e-15 56.6 16.9 0.021 15.1 0.0 8.3 8 0 0 8 8 7 4 AAA domain Zeta_toxin PF06414.7 EWC47023.1 - 1.2e-14 53.8 0.3 0.028 13.5 0.0 7.1 7 0 0 7 7 6 3 Zeta toxin AAA_19 PF13245.1 EWC47023.1 - 2e-14 53.0 7.4 0.084 12.6 0.0 6.7 6 0 0 6 6 6 4 Part of AAA domain RNA_helicase PF00910.17 EWC47023.1 - 2.4e-14 53.3 1.5 0.034 14.3 0.0 7.3 7 0 0 7 7 7 2 RNA helicase NACHT PF05729.7 EWC47023.1 - 1.2e-12 47.8 4.5 0.017 14.7 0.0 6.7 6 0 0 6 6 6 3 NACHT domain UPF0079 PF02367.12 EWC47023.1 - 8.1e-12 44.8 1.5 0.039 13.5 0.0 6.0 5 0 0 5 5 5 2 Uncharacterised P-loop hydrolase UPF0079 Mg_chelatase PF01078.16 EWC47023.1 - 1.5e-11 43.8 2.9 7.2 5.7 0.0 9.1 10 0 0 10 10 9 0 Magnesium chelatase, subunit ChlI AAA_29 PF13555.1 EWC47023.1 - 2.2e-11 43.1 0.3 0.55 9.7 0.0 6.5 6 0 0 6 6 6 1 P-loop containing region of AAA domain AAA_25 PF13481.1 EWC47023.1 - 5.5e-10 38.9 0.3 1.6 8.0 0.0 5.9 5 0 0 5 5 5 1 AAA domain Miro PF08477.8 EWC47023.1 - 9.5e-10 39.0 0.8 2 8.9 0.0 6.7 6 0 0 6 6 6 1 Miro-like protein DUF815 PF05673.8 EWC47023.1 - 4.9e-09 35.4 0.8 3.3 6.5 0.0 6.2 6 0 0 6 6 6 0 Protein of unknown function (DUF815) MobB PF03205.9 EWC47023.1 - 1.2e-08 34.7 4.5 0.58 9.8 0.0 6.2 6 0 0 6 6 6 2 Molybdopterin guanine dinucleotide synthesis protein B DUF258 PF03193.11 EWC47023.1 - 2.3e-08 33.3 2.5 1.3 8.1 0.0 5.9 6 0 0 6 6 6 1 Protein of unknown function, DUF258 IstB_IS21 PF01695.12 EWC47023.1 - 4.9e-08 32.6 0.5 1.1 8.6 0.0 6.3 6 0 0 6 6 6 1 IstB-like ATP binding protein MMR_HSR1 PF01926.18 EWC47023.1 - 5.5e-08 32.7 0.0 1.4 8.8 0.0 5.8 5 0 0 5 5 5 1 50S ribosome-binding GTPase RuvB_N PF05496.7 EWC47023.1 - 5.7e-08 32.0 4.0 0.49 9.4 0.0 6.5 7 0 0 7 7 6 2 Holliday junction DNA helicase ruvB N-terminus PduV-EutP PF10662.4 EWC47023.1 - 1.7e-06 27.5 0.3 0.11 11.9 0.0 4.8 5 0 0 5 5 4 2 Ethanolamine utilisation - propanediol utilisation SRP54 PF00448.17 EWC47023.1 - 2e-06 27.3 3.5 0.25 10.7 0.1 5.2 5 0 0 5 5 5 2 SRP54-type protein, GTPase domain DEAD PF00270.24 EWC47023.1 - 6.9e-06 25.6 0.0 4.4 6.7 0.0 5.1 5 0 0 5 5 4 0 DEAD/DEAH box helicase FtsK_SpoIIIE PF01580.13 EWC47023.1 - 2.2e-05 24.0 0.7 2.2 7.7 0.0 5.1 5 0 0 5 5 5 1 FtsK/SpoIIIE family Bac_DnaA PF00308.13 EWC47023.1 - 6.7e-05 22.6 0.8 3.9 7.0 0.0 4.8 5 0 0 5 5 4 0 Bacterial dnaA protein TIP49 PF06068.8 EWC47023.1 - 0.00011 21.0 1.6 0.34 9.5 0.1 4.4 5 0 0 5 5 5 1 TIP49 C-terminus AAA_28 PF13521.1 EWC47023.1 - 0.00011 22.1 12.0 7.8 6.4 0.0 6.5 7 0 0 7 7 5 0 AAA domain KaiC PF06745.8 EWC47023.1 - 0.00013 21.1 0.5 6.8 5.7 0.0 5.5 7 0 0 7 7 6 0 KaiC NTPase_1 PF03266.10 EWC47023.1 - 0.00021 21.0 5.4 2.2 7.9 0.0 5.2 6 0 0 6 6 4 1 NTPase cobW PF02492.14 EWC47023.1 - 0.00027 20.4 5.2 2.6 7.4 0.0 6.1 6 0 0 6 6 6 1 CobW/HypB/UreG, nucleotide-binding domain ArgK PF03308.11 EWC47023.1 - 0.00044 19.1 0.2 0.7 8.6 0.0 3.5 4 0 0 4 4 3 1 ArgK protein AAA_24 PF13479.1 EWC47023.1 - 0.00058 19.5 0.6 31 4.0 0.0 6.0 6 0 0 6 6 6 0 AAA domain PhoH PF02562.11 EWC47023.1 - 0.0022 17.2 0.7 8.7 5.5 0.0 4.4 4 0 0 4 4 4 0 PhoH-like protein AAA_6 PF12774.2 EWC47023.1 - 0.0031 17.0 0.0 2.9 7.3 0.0 4.9 6 0 0 6 6 5 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_7 PF12775.2 EWC47023.1 - 0.0037 16.3 0.6 1.3 8.0 0.0 3.6 4 0 0 4 4 4 1 P-loop containing dynein motor region D3 RPW8 PF05659.6 EWC47023.1 - 0.035 13.6 1.6 0.13 11.8 0.0 2.5 2 0 0 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 CPT PF07931.7 EWC47023.1 - 0.059 12.9 1.5 25 4.4 0.0 4.5 4 1 0 4 4 3 0 Chloramphenicol phosphotransferase-like protein ATP_bind_1 PF03029.12 EWC47023.1 - 0.22 11.0 7.7 27 4.2 0.0 5.4 6 0 0 6 6 6 0 Conserved hypothetical ATP binding protein Y_phosphatase PF00102.22 EWC47023.1 - 1.5 8.1 1.4 7.1 5.8 0.0 2.8 4 0 0 4 4 3 0 Protein-tyrosine phosphatase SIN1 PF05422.7 EWC47024.1 - 5.2e-48 163.8 0.0 1.2e-46 159.3 0.0 2.8 2 1 0 2 2 2 1 Stress-activated map kinase interacting protein 1 (SIN1) PHD PF00628.24 EWC47025.1 - 1.9e-11 43.4 10.0 2.6e-10 39.8 2.7 2.6 2 0 0 2 2 2 2 PHD-finger zf-RING_2 PF13639.1 EWC47025.1 - 1.1e-09 37.8 1.4 1.1e-09 37.8 1.0 3.5 4 0 0 4 4 4 1 Ring finger domain zf-rbx1 PF12678.2 EWC47025.1 - 2.4e-08 33.9 0.5 2.4e-08 33.9 0.4 2.3 2 0 0 2 2 2 1 RING-H2 zinc finger zf-C3HC4 PF00097.20 EWC47025.1 - 1.5e-05 24.5 1.2 1.5e-05 24.5 0.8 2.8 3 1 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EWC47025.1 - 8.7e-05 22.1 2.6 8.7e-05 22.1 1.8 2.9 2 1 0 2 2 2 1 zinc-RING finger domain PHD_2 PF13831.1 EWC47025.1 - 9.2e-05 21.6 1.5 9.2e-05 21.6 1.0 1.9 2 0 0 2 2 2 1 PHD-finger zf-C3HC4_3 PF13920.1 EWC47025.1 - 0.00016 21.3 4.9 0.00016 21.3 3.4 3.2 2 2 1 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 EWC47025.1 - 0.00031 20.7 3.4 0.00031 20.7 2.4 3.5 3 2 1 4 4 4 2 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 EWC47025.1 - 0.00033 20.4 5.1 0.0033 17.2 0.1 2.4 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_1 PF14446.1 EWC47025.1 - 0.015 15.0 0.9 0.015 15.0 0.6 2.6 2 1 0 2 2 2 0 Prokaryotic RING finger family 1 zf-PHD-like PF15446.1 EWC47025.1 - 0.018 14.3 0.9 0.065 12.5 0.1 2.0 2 0 0 2 2 2 0 PHD/FYVE-zinc-finger like domain Prok-RING_4 PF14447.1 EWC47025.1 - 0.043 13.3 0.5 0.043 13.3 0.4 1.8 2 0 0 2 2 1 0 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.1 EWC47025.1 - 0.047 13.4 1.2 3.9 7.2 0.1 2.7 2 0 0 2 2 2 0 RING-type zinc-finger UPF0164 PF03687.8 EWC47025.1 - 0.29 9.6 0.0 0.43 9.0 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0164) Dynactin_p62 PF05502.8 EWC47025.1 - 0.55 8.9 4.0 0.12 11.1 0.5 1.4 2 0 0 2 2 2 0 Dynactin p62 family Ribosomal_L37ae PF01780.14 EWC47026.1 - 1e-39 134.2 7.9 1.2e-39 134.1 5.5 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family A2L_zn_ribbon PF08792.5 EWC47026.1 - 0.011 15.2 4.3 0.022 14.2 0.1 2.1 2 0 0 2 2 2 0 A2L zinc ribbon domain Zn_Tnp_IS1595 PF12760.2 EWC47026.1 - 0.015 15.1 2.4 0.022 14.5 1.6 1.3 1 0 0 1 1 1 0 Transposase zinc-ribbon domain OrfB_Zn_ribbon PF07282.6 EWC47026.1 - 0.016 14.8 1.2 0.021 14.4 0.8 1.2 1 0 0 1 1 1 0 Putative transposase DNA-binding domain Zn-ribbon_8 PF09723.5 EWC47026.1 - 0.043 13.7 1.5 0.58 10.1 0.1 2.2 2 0 0 2 2 2 0 Zinc ribbon domain Elf1 PF05129.8 EWC47026.1 - 0.047 13.3 1.6 0.082 12.6 1.1 1.4 1 1 0 1 1 1 0 Transcription elongation factor Elf1 like zf-H2C2_2 PF13465.1 EWC47026.1 - 0.073 13.3 1.6 0.24 11.7 0.2 2.1 2 0 0 2 2 2 0 Zinc-finger double domain Sgf11 PF08209.6 EWC47026.1 - 0.094 12.0 0.3 1.3 8.3 0.0 2.2 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) zf-BED PF02892.10 EWC47026.1 - 0.1 12.3 4.1 2.1 8.1 0.1 2.3 1 1 1 2 2 2 0 BED zinc finger DNA_RNApol_7kD PF03604.8 EWC47026.1 - 0.19 11.2 1.5 9.2 5.8 0.0 2.3 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit zf-Sec23_Sec24 PF04810.10 EWC47026.1 - 0.2 11.2 0.9 0.74 9.4 0.0 2.0 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger zf-ribbon_3 PF13248.1 EWC47026.1 - 0.32 10.2 2.3 5.1 6.4 0.1 2.2 2 0 0 2 2 2 0 zinc-ribbon domain zf-C2H2 PF00096.21 EWC47026.1 - 0.36 11.2 2.4 5.3 7.5 0.2 2.3 2 0 0 2 2 2 0 Zinc finger, C2H2 type DUF972 PF06156.8 EWC47027.1 - 3.9 7.8 7.5 2.6 8.4 2.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF972) SRPRB PF09439.5 EWC47028.1 - 3.9e-28 97.9 0.1 2.5e-27 95.2 0.0 2.1 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.7 EWC47028.1 - 0.00036 19.7 0.0 0.00048 19.3 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 EWC47028.1 - 0.0051 16.2 0.0 0.018 14.4 0.0 1.7 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Arf PF00025.16 EWC47028.1 - 0.0054 15.9 0.0 0.025 13.8 0.0 2.1 1 1 0 1 1 1 1 ADP-ribosylation factor family PduV-EutP PF10662.4 EWC47028.1 - 0.04 13.3 0.0 0.28 10.6 0.0 2.0 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Miro PF08477.8 EWC47028.1 - 0.05 14.0 0.0 0.087 13.3 0.0 1.4 1 0 0 1 1 1 0 Miro-like protein AAA_16 PF13191.1 EWC47028.1 - 0.08 12.9 0.1 0.14 12.1 0.1 1.4 1 0 0 1 1 1 0 AAA ATPase domain DUF3517 PF12030.3 EWC47029.1 - 1.3e-46 158.6 0.1 1.1e-45 155.6 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF3517) UCH PF00443.24 EWC47029.1 - 1.1e-44 152.6 0.0 2e-44 151.7 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 EWC47029.1 - 2.4e-18 66.5 0.0 4.3e-18 65.7 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase PseudoU_synth_1 PF01416.15 EWC47030.1 - 5.6e-23 81.3 0.0 2.5e-10 40.7 0.0 2.5 2 0 0 2 2 2 2 tRNA pseudouridine synthase UPF0113 PF03657.8 EWC47031.1 - 4.3e-08 32.9 0.0 5.3e-08 32.6 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0113) SRP72 PF08492.7 EWC47032.1 - 2.6e-15 56.5 6.8 2.6e-15 56.5 4.7 2.3 2 0 0 2 2 2 1 SRP72 RNA-binding domain TPR_19 PF14559.1 EWC47032.1 - 3.9e-06 27.0 24.3 0.33 11.3 0.0 7.6 6 1 2 8 8 8 3 Tetratricopeptide repeat TPR_16 PF13432.1 EWC47032.1 - 1.1e-05 25.9 16.7 0.54 11.0 0.0 6.8 6 1 0 6 6 6 2 Tetratricopeptide repeat Apc3 PF12895.2 EWC47032.1 - 0.00088 19.3 17.1 0.67 10.1 0.9 5.4 6 1 1 7 7 7 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.12 EWC47032.1 - 0.001 18.8 9.9 3.1 7.9 0.0 5.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.1 EWC47032.1 - 0.0016 18.7 10.4 50 4.6 0.1 7.8 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_7 PF13176.1 EWC47032.1 - 0.0026 17.4 2.2 31 4.6 0.0 5.7 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.23 EWC47032.1 - 0.0027 17.2 6.9 3.1 7.5 0.0 4.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.1 EWC47032.1 - 3 8.7 19.7 22 6.0 0.0 7.5 6 1 3 9 9 9 0 Tetratricopeptide repeat Lectin_leg-like PF03388.8 EWC47033.1 - 1.7e-30 105.8 0.0 2.5e-30 105.3 0.0 1.2 1 0 0 1 1 1 1 Legume-like lectin family Apc15p PF05841.6 EWC47033.1 - 0.023 15.4 4.6 0.056 14.1 3.2 1.6 1 0 0 1 1 1 0 Apc15p protein DUF1664 PF07889.7 EWC47033.1 - 0.042 13.6 0.4 0.1 12.4 0.1 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) V_ATPase_I PF01496.14 EWC47033.1 - 1.7 6.4 3.6 1.4 6.6 1.6 1.3 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family TFIIE_alpha PF02002.12 EWC47034.1 - 1.2e-17 63.2 0.7 2.4e-17 62.3 0.5 1.5 1 0 0 1 1 1 1 TFIIE alpha subunit TF_Zn_Ribbon PF08271.7 EWC47034.1 - 0.013 14.7 0.4 0.028 13.7 0.3 1.5 1 0 0 1 1 1 0 TFIIB zinc-binding DiS_P_DiS PF06750.8 EWC47034.1 - 0.076 12.8 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Bacterial Peptidase A24 N-terminal domain DZR PF12773.2 EWC47034.1 - 0.11 12.2 0.3 0.32 10.8 0.2 1.7 1 1 0 1 1 1 0 Double zinc ribbon zf-TFIIB PF13453.1 EWC47034.1 - 0.15 11.2 0.4 0.29 10.3 0.3 1.5 1 0 0 1 1 1 0 Transcription factor zinc-finger RRN7 PF11781.3 EWC47034.1 - 0.42 10.1 2.5 1.8 8.0 0.2 2.4 2 0 0 2 2 2 0 RNA polymerase I-specific transcription initiation factor Rrn7 NOC3p PF07540.6 EWC47035.1 - 2.3e-31 107.9 0.5 2.3e-31 107.9 0.3 2.6 3 0 0 3 3 3 1 Nucleolar complex-associated protein CBF PF03914.12 EWC47035.1 - 5.2e-24 84.5 0.2 3.7e-23 81.7 0.0 2.2 2 0 0 2 2 2 1 CBF/Mak21 family RepA1_leader PF08048.7 EWC47035.1 - 0.16 12.0 2.2 4.1 7.5 0.4 2.6 2 0 0 2 2 2 0 Tap RepA1 leader peptide Ubiq_cyt_C_chap PF03981.7 EWC47036.1 - 2e-27 95.7 1.7 3.9e-27 94.8 1.2 1.4 1 0 0 1 1 1 1 Ubiquinol-cytochrome C chaperone TIP41 PF04176.8 EWC47037.1 - 3e-74 248.2 0.1 3.7e-74 247.9 0.1 1.1 1 0 0 1 1 1 1 TIP41-like family DUF4279 PF14106.1 EWC47037.1 - 0.089 12.6 0.0 5.8 6.8 0.0 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4279) Methyltransf_27 PF13708.1 EWC47037.1 - 0.1 12.1 0.0 0.32 10.5 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain HAD PF12710.2 EWC47038.1 - 1.2e-18 67.9 0.1 5e-18 65.9 0.1 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.15 EWC47038.1 - 9.5e-18 64.0 0.2 1.6e-17 63.3 0.1 1.3 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.21 EWC47038.1 - 4.6e-14 53.3 0.2 4.4e-13 50.1 0.1 2.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 EWC47038.1 - 6.1e-12 45.3 0.0 1.5e-11 44.0 0.0 1.7 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 EWC47038.1 - 0.0011 18.6 0.4 0.0048 16.5 0.3 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 EWC47038.1 - 0.076 13.2 0.0 0.18 12.0 0.0 1.6 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase MRP-L46 PF11788.3 EWC47039.1 - 3.3e-23 82.4 1.3 6.2e-23 81.5 0.3 1.8 2 0 0 2 2 2 1 39S mitochondrial ribosomal protein L46 NUDIX PF00293.23 EWC47039.1 - 0.037 13.6 0.0 0.097 12.3 0.0 1.7 1 1 0 1 1 1 0 NUDIX domain Cofilin_ADF PF00241.15 EWC47040.1 - 1.1e-18 67.3 0.0 4.4e-08 33.0 0.0 2.2 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein Mito_carr PF00153.22 EWC47041.1 - 1.8e-68 226.3 1.8 2.4e-22 78.4 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein SCA7 PF08313.7 EWC47042.1 - 2.2e-33 113.6 0.4 2.2e-33 113.6 0.3 2.0 2 0 0 2 2 2 1 SCA7, zinc-binding domain DUF4554 PF15091.1 EWC47042.1 - 1.3 7.7 7.3 2.1 7.0 5.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4554) zf-TRAF PF02176.13 EWC47042.1 - 1.3 9.4 5.5 0.76 10.2 1.5 2.1 2 0 0 2 2 2 0 TRAF-type zinc finger MMR_HSR1 PF01926.18 EWC47043.1 - 2.1e-09 37.3 0.1 6.9e-09 35.6 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.11 EWC47043.1 - 1.8e-05 23.9 0.0 4.6e-05 22.6 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function, DUF258 ABC_tran PF00005.22 EWC47043.1 - 0.00076 19.7 0.2 0.00076 19.7 0.1 2.7 2 0 0 2 2 2 1 ABC transporter AAA_23 PF13476.1 EWC47043.1 - 0.002 18.5 15.9 0.0054 17.0 0.1 2.7 3 0 0 3 3 2 1 AAA domain AAA_21 PF13304.1 EWC47043.1 - 0.0026 17.7 0.1 0.004 17.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain IIGP PF05049.8 EWC47043.1 - 0.0029 16.4 0.1 0.0029 16.4 0.1 2.1 3 0 0 3 3 3 1 Interferon-inducible GTPase (IIGP) Miro PF08477.8 EWC47043.1 - 0.0031 18.0 1.0 0.015 15.7 0.0 2.5 2 0 0 2 2 2 1 Miro-like protein Apolipoprotein PF01442.13 EWC47043.1 - 0.0075 15.7 14.7 0.012 15.1 10.2 1.2 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain Dynamin_N PF00350.18 EWC47043.1 - 0.014 15.2 10.9 0.28 10.9 0.1 3.5 2 2 1 3 3 2 0 Dynamin family AAA_29 PF13555.1 EWC47043.1 - 0.044 13.3 0.8 0.11 12.0 0.4 1.8 2 0 0 2 2 1 0 P-loop containing region of AAA domain Atg14 PF10186.4 EWC47043.1 - 0.049 12.5 15.8 0.081 11.8 11.0 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 AAA_10 PF12846.2 EWC47043.1 - 0.1 12.0 1.4 3.2 7.1 0.1 2.1 2 0 0 2 2 2 0 AAA-like domain DASH_Spc19 PF08287.6 EWC47043.1 - 0.14 11.7 11.5 0.24 10.9 8.0 1.3 1 0 0 1 1 1 0 Spc19 AAA_22 PF13401.1 EWC47043.1 - 0.16 12.1 2.0 0.3 11.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain CorA PF01544.13 EWC47043.1 - 0.5 9.3 4.8 1 8.3 3.3 1.4 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein DUF3584 PF12128.3 EWC47043.1 - 0.63 7.2 21.7 0.88 6.8 15.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF87 PF01935.12 EWC47043.1 - 0.81 9.4 8.3 0.79 9.5 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function DUF87 AAA_13 PF13166.1 EWC47043.1 - 0.83 8.0 13.3 1.3 7.3 9.2 1.2 1 0 0 1 1 1 0 AAA domain Hom_end_hint PF05203.11 EWC47043.1 - 1.6 8.4 7.1 35 4.0 0.0 2.3 2 0 0 2 2 2 0 Hom_end-associated Hint DUF2935 PF11155.3 EWC47043.1 - 4.3 7.4 9.9 13 5.8 0.4 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF2935) YlqD PF11068.3 EWC47043.1 - 6.7 6.7 24.5 16 5.5 9.7 2.3 1 1 1 2 2 2 0 YlqD protein DUF972 PF06156.8 EWC47043.1 - 6.8 7.0 18.6 2.4 8.5 3.3 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF972) V_ATPase_I PF01496.14 EWC47043.1 - 7.8 4.2 9.3 15 3.2 6.4 1.4 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF342 PF03961.8 EWC47043.1 - 8.2 4.7 16.8 25 3.1 11.7 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF342) TPR_MLP1_2 PF07926.7 EWC47043.1 - 8.8 6.0 24.2 2.3e+02 1.4 16.3 2.2 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein OmpH PF03938.9 EWC47043.1 - 9.4 6.1 20.9 18 5.2 14.5 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) ketoacyl-synt PF00109.21 EWC47045.1 - 1.6e-55 188.3 1.2 1.6e-55 188.3 0.8 2.0 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.17 EWC47045.1 - 1.3e-26 92.7 0.6 3.8e-26 91.2 0.3 1.8 1 1 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.18 EWC47045.1 - 7.1e-05 21.9 0.0 0.00012 21.1 0.0 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain ACP_syn_III PF08545.5 EWC47045.1 - 0.11 12.1 1.7 8.4 6.1 0.1 2.9 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III CAF1 PF04857.15 EWC47046.1 - 8.4e-48 162.9 0.0 1e-47 162.7 0.0 1.1 1 0 0 1 1 1 1 CAF1 family ribonuclease R3H PF01424.17 EWC47046.1 - 0.033 13.8 0.0 0.074 12.7 0.0 1.6 1 0 0 1 1 1 0 R3H domain ABC_trans_N PF14510.1 EWC47047.1 - 0.11 12.5 0.0 0.22 11.6 0.0 1.4 1 0 0 1 1 1 0 ABC-transporter extracellular N-terminal Pkinase PF00069.20 EWC47048.1 - 6.9e-70 235.1 0.0 9.7e-70 234.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC47048.1 - 5.6e-43 146.8 0.0 7.5e-43 146.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EWC47048.1 - 4.8e-08 32.3 0.0 3.4e-07 29.5 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.9 EWC47048.1 - 0.00017 20.6 0.0 0.00026 20.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 EWC47048.1 - 0.039 13.2 0.0 0.26 10.6 0.0 2.0 1 1 1 2 2 2 0 RIO1 family YrbL-PhoP_reg PF10707.4 EWC47048.1 - 0.042 13.1 0.0 0.098 11.9 0.0 1.7 1 1 0 1 1 1 0 PhoP regulatory network protein YrbL APH PF01636.18 EWC47048.1 - 0.1 12.3 0.5 0.3 10.7 0.0 2.0 2 1 1 3 3 3 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 EWC47048.1 - 0.1 11.4 0.0 0.24 10.2 0.0 1.5 2 0 0 2 2 2 0 Seadornavirus VP7 Peptidase_M76 PF09768.4 EWC47049.1 - 4.7e-64 215.0 0.8 2.8e-63 212.4 0.5 1.8 1 1 0 1 1 1 1 Peptidase M76 family DUF2039 PF10217.4 EWC47049.1 - 0.06 13.3 2.7 0.81 9.7 0.0 2.6 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2039) SprT-like PF10263.4 EWC47049.1 - 0.17 11.5 5.7 0.053 13.1 1.5 2.1 1 1 1 2 2 2 0 SprT-like family AA_kinase PF00696.23 EWC47050.1 - 7.7e-38 130.3 0.7 1.1e-37 129.8 0.5 1.2 1 0 0 1 1 1 1 Amino acid kinase family PUA PF01472.15 EWC47050.1 - 4.9e-15 55.0 0.7 1.4e-14 53.5 0.5 1.8 1 0 0 1 1 1 1 PUA domain DEAD PF00270.24 EWC47051.1 - 4.5e-27 94.5 0.0 7.3e-27 93.9 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EWC47051.1 - 3.8e-13 49.1 0.1 8.3e-13 48.0 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Anillin PF08174.6 EWC47052.1 - 9.9e-24 83.9 1.6 1.8e-23 83.1 0.1 2.3 2 0 0 2 2 2 1 Cell division protein anillin PH PF00169.24 EWC47052.1 - 8e-09 35.6 0.0 2.4e-08 34.0 0.0 1.8 1 0 0 1 1 1 1 PH domain PH_11 PF15413.1 EWC47052.1 - 0.025 14.8 0.1 0.063 13.5 0.0 1.7 1 0 0 1 1 1 0 Pleckstrin homology domain RNase_P_pop3 PF08228.6 EWC47053.1 - 0.054 13.3 0.1 0.19 11.5 0.0 1.8 1 1 0 1 1 1 0 RNase P subunit Pop3 Hydrophobin PF01185.13 EWC47054.1 - 0.00089 19.6 14.8 0.0027 18.1 9.7 2.0 1 1 0 1 1 1 1 Fungal hydrophobin PALP PF00291.20 EWC47055.1 - 9.6e-61 205.6 0.2 1.2e-60 205.2 0.1 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CBS PF00571.23 EWC47055.1 - 2.1e-12 46.5 0.7 2.5e-09 36.7 0.0 2.8 3 0 0 3 3 3 2 CBS domain Ank PF00023.25 EWC47056.1 - 9.5e-40 132.4 0.9 3e-11 42.5 0.1 6.7 7 0 0 7 7 7 5 Ankyrin repeat Ank_2 PF12796.2 EWC47056.1 - 2.8e-38 130.1 0.0 7.3e-15 55.0 0.0 3.4 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) zf-DHHC PF01529.15 EWC47056.1 - 3.5e-34 117.6 4.3 3.5e-34 117.6 3.0 2.1 1 1 1 2 2 2 1 DHHC palmitoyltransferase Ank_5 PF13857.1 EWC47056.1 - 6.6e-28 96.0 10.9 2e-07 31.0 0.1 5.3 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.1 EWC47056.1 - 3.8e-25 85.4 3.3 7.7e-08 31.8 0.1 6.1 6 0 0 6 6 6 5 Ankyrin repeat Ank_4 PF13637.1 EWC47056.1 - 1.5e-22 79.5 1.0 1.3e-07 31.9 0.0 4.2 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Voltage_CLC PF00654.15 EWC47058.1 - 6.9e-94 314.7 15.3 6.9e-94 314.7 10.6 1.7 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.23 EWC47058.1 - 0.0017 18.0 0.1 0.03 14.1 0.0 2.4 2 0 0 2 2 2 1 CBS domain TAT_signal PF10518.4 EWC47058.1 - 0.0067 16.3 2.4 0.0067 16.3 1.7 3.7 4 0 0 4 4 4 1 TAT (twin-arginine translocation) pathway signal sequence Pecanex_C PF05041.10 EWC47059.1 - 0.035 13.1 0.1 0.036 13.0 0.0 1.1 1 0 0 1 1 1 0 Pecanex protein (C-terminus) Lipase_GDSL_2 PF13472.1 EWC47060.1 - 1.4e-21 77.4 0.1 1.8e-21 77.1 0.1 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.17 EWC47060.1 - 8.4e-12 45.4 0.0 9.6e-12 45.2 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Gemini_C4 PF01492.12 EWC47061.1 - 0.022 14.5 0.9 0.022 14.5 0.6 2.4 2 0 0 2 2 2 0 Geminivirus C4 protein Isochorismatase PF00857.15 EWC47062.1 - 1.8e-28 99.6 0.1 4e-28 98.5 0.1 1.5 1 1 0 1 1 1 1 Isochorismatase family DsrH PF04077.7 EWC47062.1 - 0.13 11.9 0.0 0.3 10.7 0.0 1.7 1 0 0 1 1 1 0 DsrH like protein Lectin_leg-like PF03388.8 EWC47063.1 - 2.3e-68 229.7 0.0 2.8e-68 229.4 0.0 1.1 1 0 0 1 1 1 1 Legume-like lectin family Lectin_legB PF00139.14 EWC47063.1 - 0.00026 20.4 0.0 0.00082 18.8 0.0 1.7 1 1 0 1 1 1 1 Legume lectin domain ATG27 PF09451.5 EWC47063.1 - 0.049 12.8 0.0 0.06 12.5 0.0 1.2 1 0 0 1 1 1 0 Autophagy-related protein 27 Zip PF02535.17 EWC47064.1 - 5.6e-25 88.0 13.4 7.2e-24 84.3 9.3 2.1 1 1 0 1 1 1 1 ZIP Zinc transporter GWT1 PF06423.7 EWC47064.1 - 0.0058 16.7 0.1 0.012 15.6 0.1 1.5 1 0 0 1 1 1 1 GWT1 ICMT PF04140.9 EWC47065.1 - 8.9e-28 96.3 0.9 1.9e-27 95.2 0.6 1.6 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.8 EWC47065.1 - 3.4e-13 49.6 1.3 3.4e-13 49.6 0.9 2.1 2 0 0 2 2 2 1 Phospholipid methyltransferase DUF1295 PF06966.7 EWC47065.1 - 0.0043 16.3 0.6 0.0047 16.2 0.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) Pkinase PF00069.20 EWC47067.1 - 1.1e-56 191.8 0.5 3e-56 190.4 0.4 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC47067.1 - 1.3e-17 63.7 0.1 1e-16 60.7 0.0 2.3 2 1 0 2 2 2 1 Protein tyrosine kinase DUF2458 PF10454.4 EWC47068.1 - 3.5e-29 101.6 2.8 7.2e-17 61.6 0.5 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF2458) BSP_II PF05432.6 EWC47069.1 - 0.16 11.2 2.2 0.21 10.8 0.8 1.6 1 1 1 2 2 2 0 Bone sialoprotein II (BSP-II) ERG2_Sigma1R PF04622.7 EWC47070.1 - 3.1e-67 225.9 0.2 3.8e-67 225.7 0.1 1.0 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein zf-AN1 PF01428.11 EWC47072.1 - 0.14 12.0 18.0 1.3 8.9 8.8 3.2 2 1 1 3 3 3 0 AN1-like Zinc finger zf-C2HC5 PF06221.8 EWC47072.1 - 2.8 7.7 12.2 0.28 10.9 5.3 1.8 1 1 0 1 1 1 0 Putative zinc finger motif, C2HC5-type ATP-grasp_5 PF13549.1 EWC47073.1 - 0.13 11.4 0.0 0.15 11.2 0.0 1.0 1 0 0 1 1 1 0 ATP-grasp domain Acetyltransf_1 PF00583.19 EWC47076.1 - 2.1e-09 37.2 0.8 1.2e-08 34.8 0.6 2.1 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 EWC47076.1 - 5.7e-06 26.4 0.0 0.00015 21.8 0.0 2.2 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 EWC47076.1 - 3.3e-05 23.9 0.0 0.0051 16.9 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 EWC47076.1 - 0.0023 17.7 0.0 0.053 13.3 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.1 EWC47076.1 - 0.012 15.4 0.0 0.039 13.8 0.0 1.8 2 0 0 2 2 2 0 GCN5-related N-acetyl-transferase DUF3749 PF12568.3 EWC47076.1 - 0.024 14.2 0.3 0.055 13.0 0.2 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 EWC47076.1 - 0.052 13.4 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain FR47 PF08445.5 EWC47076.1 - 0.091 12.5 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 FR47-like protein VWA PF00092.23 EWC47077.1 - 3.4e-10 39.9 0.0 7.8e-10 38.7 0.0 1.5 1 1 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.1 EWC47077.1 - 4.3e-09 36.7 0.0 1.3e-08 35.0 0.0 1.7 1 1 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.1 EWC47077.1 - 5.7e-06 26.0 0.0 8.9e-06 25.4 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain vWA-TerF-like PF10138.4 EWC47077.1 - 0.0007 19.4 0.0 0.001 18.9 0.0 1.2 1 0 0 1 1 1 1 vWA found in TerF C terminus RRM_1 PF00076.17 EWC47078.1 - 6e-09 35.4 0.0 1e-08 34.6 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EWC47078.1 - 4.5e-07 29.7 0.0 8.7e-07 28.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 EWC47078.1 - 9.2e-05 22.1 0.0 0.00017 21.2 0.0 1.5 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Pex24p PF06398.6 EWC47079.1 - 1.4e-82 277.4 2.2 1.8e-82 277.0 1.5 1.0 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin Yip1 PF04893.12 EWC47080.1 - 5.8e-09 35.6 13.4 5.8e-09 35.6 9.3 1.6 1 1 0 1 1 1 1 Yip1 domain Elongin_A PF06881.6 EWC47081.1 - 0.069 13.5 0.9 0.15 12.4 0.6 1.5 1 0 0 1 1 1 0 RNA polymerase II transcription factor SIII (Elongin) subunit A Spt20 PF12090.3 EWC47083.1 - 7e-40 136.3 0.0 7e-40 136.3 0.0 4.0 4 1 0 4 4 4 2 Spt20 family NTP_transferase PF00483.18 EWC47084.1 - 1.2e-10 41.1 0.0 1.9e-10 40.4 0.0 1.3 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.19 EWC47084.1 - 1.3e-08 33.9 9.3 0.00045 19.5 0.5 2.8 1 1 1 2 2 2 2 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.2 EWC47084.1 - 2.6e-05 24.3 0.0 5e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 MobA-like NTP transferase domain CTP_transf_3 PF02348.14 EWC47084.1 - 0.075 12.6 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 Cytidylyltransferase CDP-OH_P_transf PF01066.16 EWC47085.1 - 5.4e-21 74.8 1.2 5.4e-21 74.8 0.8 1.5 2 0 0 2 2 2 1 CDP-alcohol phosphatidyltransferase DUF4140 PF13600.1 EWC47086.1 - 0.019 15.4 2.0 6.3 7.3 0.0 3.3 3 0 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) DivIC PF04977.10 EWC47086.1 - 0.08 12.4 0.2 0.08 12.4 0.1 1.7 2 0 0 2 2 2 0 Septum formation initiator Nnf1 PF03980.9 EWC47086.1 - 0.084 12.8 1.1 1.4 8.9 0.7 2.2 2 0 0 2 2 2 0 Nnf1 DUF3972 PF13118.1 EWC47086.1 - 0.17 11.9 2.8 0.11 12.5 0.6 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3972) FlaC_arch PF05377.6 EWC47086.1 - 0.97 9.3 4.8 0.23 11.3 0.6 2.0 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) DivIVA PF05103.8 EWC47086.1 - 1.2 9.1 4.9 0.5 10.4 0.6 2.0 2 0 0 2 2 2 0 DivIVA protein Tmemb_cc2 PF10267.4 EWC47086.1 - 3.6 6.0 9.5 16 3.9 6.6 2.0 1 1 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein DNA_ligase_OB_2 PF14743.1 EWC47087.1 - 1.8e-27 94.7 0.8 3.9e-27 93.7 0.5 1.6 1 0 0 1 1 1 1 DNA ligase OB-like domain DNA_ligase_A_M PF01068.16 EWC47087.1 - 1.5e-17 63.6 0.0 3.2e-17 62.5 0.0 1.5 1 0 0 1 1 1 1 ATP dependent DNA ligase domain Cwf_Cwc_15 PF04889.7 EWC47087.1 - 0.008 15.9 23.1 0.2 11.3 5.4 2.3 2 0 0 2 2 2 2 Cwf15/Cwc15 cell cycle control protein FYDLN_acid PF09538.5 EWC47087.1 - 0.74 10.4 29.2 3.1 8.4 8.3 2.6 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) TLP-20 PF06088.6 EWC47087.1 - 0.85 9.2 11.5 0.56 9.8 1.2 2.3 2 0 0 2 2 2 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) RNase_H2-Ydr279 PF09468.5 EWC47087.1 - 2.2 7.3 6.2 3.9 6.5 4.3 1.4 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) Pox_Ag35 PF03286.9 EWC47087.1 - 3.4 7.1 27.1 0.074 12.5 8.6 2.3 1 1 1 2 2 2 0 Pox virus Ag35 surface protein Prothymosin PF03247.9 EWC47087.1 - 5.8 7.1 39.7 7.8 6.7 9.8 2.6 2 0 0 2 2 2 0 Prothymosin/parathymosin family RXT2_N PF08595.6 EWC47087.1 - 6.3 6.5 18.6 8.6 6.1 4.1 2.7 2 0 0 2 2 2 0 RXT2-like, N-terminal DUF2457 PF10446.4 EWC47087.1 - 7.6 5.1 35.2 0.064 11.9 9.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) Calc_CGRP_IAPP PF00214.14 EWC47088.1 - 1.7 8.6 6.2 0.32 11.0 0.4 2.2 1 1 1 2 2 2 0 Calcitonin / CGRP / IAPP family DUF936 PF06075.7 EWC47088.1 - 9.3 5.0 21.7 13 4.5 15.0 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) GMC_oxred_N PF00732.14 EWC47090.1 - 1.7e-38 132.4 1.1 9.1e-38 130.0 0.1 2.1 2 0 0 2 2 2 1 GMC oxidoreductase GMC_oxred_C PF05199.8 EWC47090.1 - 4.8e-23 82.0 0.0 2.4e-22 79.7 0.0 2.1 2 0 0 2 2 2 1 GMC oxidoreductase NAD_binding_8 PF13450.1 EWC47090.1 - 0.033 14.2 0.1 0.093 12.7 0.0 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain CPSF73-100_C PF11718.3 EWC47091.1 - 3e-61 206.5 0.0 4.2e-61 206.0 0.0 1.2 1 0 0 1 1 1 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Beta-Casp PF10996.3 EWC47091.1 - 4.8e-32 110.5 0.0 1.8e-31 108.7 0.0 1.9 2 0 0 2 2 2 1 Beta-Casp domain Lactamase_B PF00753.22 EWC47091.1 - 3.2e-15 56.2 1.1 1.1e-14 54.5 0.7 1.9 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 EWC47091.1 - 4.8e-10 39.2 1.1 1.1e-09 38.1 0.7 1.6 1 0 0 1 1 1 1 Beta-lactamase superfamily domain RMMBL PF07521.7 EWC47091.1 - 4.7e-07 29.5 0.0 9.7e-07 28.5 0.0 1.6 1 0 0 1 1 1 1 RNA-metabolising metallo-beta-lactamase Lactamase_B_3 PF13483.1 EWC47091.1 - 5.1e-05 23.0 0.3 0.00027 20.6 0.2 2.2 2 0 0 2 2 2 1 Beta-lactamase superfamily domain zf-C2H2 PF00096.21 EWC47092.1 - 2.6e-09 36.8 13.1 0.00012 22.2 1.0 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 EWC47092.1 - 1.8e-07 31.0 13.9 2.3e-06 27.5 1.6 3.4 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.1 EWC47092.1 - 4e-06 26.7 10.7 0.0045 17.2 2.8 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 EWC47092.1 - 0.1 12.7 5.1 4.6 7.5 1.1 2.7 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 EWC47092.1 - 0.55 10.5 3.2 0.78 10.0 0.2 2.6 2 0 0 2 2 2 0 Zinc-finger of C2H2 type Fungal_trans PF04082.13 EWC47093.1 - 6.1e-27 94.1 0.0 1.1e-26 93.2 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Pex14_N PF04695.8 EWC47093.1 - 4.2 7.4 7.4 0.49 10.4 0.0 3.1 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Mtc PF03820.12 EWC47094.1 - 1.2e-99 332.8 0.0 1.4e-99 332.6 0.0 1.0 1 0 0 1 1 1 1 Tricarboxylate carrier TauD PF02668.11 EWC47095.1 - 4.2e-48 164.2 0.1 5.2e-48 163.9 0.1 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Glyco_hydro_15 PF00723.16 EWC47096.1 - 1.3e-56 192.1 0.0 1.1e-54 185.7 0.0 2.1 1 1 0 1 1 1 1 Glycosyl hydrolases family 15 NmrA PF05368.8 EWC47097.1 - 0.0075 15.5 0.0 0.011 14.9 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family Saccharop_dh PF03435.13 EWC47097.1 - 0.097 11.6 0.0 0.13 11.2 0.0 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase APC10 PF03256.11 EWC47098.1 - 3.6e-52 176.7 0.0 4.8e-52 176.3 0.0 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) SAPS PF04499.10 EWC47098.1 - 0.38 9.3 5.2 0.43 9.1 3.6 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF4045 PF13254.1 EWC47098.1 - 0.63 9.2 4.5 0.82 8.8 3.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Ycf1 PF05758.7 EWC47098.1 - 4.1 4.9 6.6 5.1 4.6 4.5 1.1 1 0 0 1 1 1 0 Ycf1 CENP-T PF15511.1 EWC47098.1 - 5.7 6.0 25.8 7.8 5.6 17.9 1.1 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T Utp14 PF04615.8 EWC47098.1 - 8.1 4.4 25.3 11 4.0 17.5 1.0 1 0 0 1 1 1 0 Utp14 protein Pilt PF15453.1 EWC47098.1 - 9.3 5.8 9.8 12 5.4 6.8 1.2 1 0 0 1 1 1 0 Protein incorporated later into Tight Junctions Iso_dh PF00180.15 EWC47099.1 - 5.5e-129 430.0 0.0 6.8e-129 429.7 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase MFS_1 PF07690.11 EWC47100.1 - 7e-30 103.9 40.6 1.6e-29 102.7 28.2 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily NfeD PF01957.13 EWC47100.1 - 0.013 15.6 0.0 0.013 15.6 0.0 3.4 3 1 2 5 5 5 0 NfeD-like C-terminal, partner-binding Fungal_trans PF04082.13 EWC47102.1 - 3.5e-26 91.6 0.0 7e-26 90.6 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EWC47102.1 - 2e-07 30.8 13.5 4.7e-07 29.5 9.3 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Mto2_bdg PF12808.2 EWC47102.1 - 0.55 10.3 4.1 0.29 11.2 0.8 2.0 2 0 0 2 2 2 0 Micro-tubular organiser Mto1 C-term Mto2-binding region T4SS PF07996.6 EWC47102.1 - 1.2 8.9 8.7 6.3 6.5 2.3 2.2 2 0 0 2 2 2 0 Type IV secretion system proteins Med6 PF04934.9 EWC47103.1 - 1.4e-42 144.5 0.2 2.7e-42 143.6 0.2 1.4 1 0 0 1 1 1 1 MED6 mediator sub complex component Tom5 PF10642.4 EWC47103.1 - 0.46 10.1 2.7 2.2 8.0 1.4 2.5 2 0 0 2 2 2 0 Mitochondrial import receptor subunit or translocase HSP20 PF00011.16 EWC47104.1 - 3.8e-12 45.9 0.1 6.3e-12 45.2 0.0 1.4 1 0 0 1 1 1 1 Hsp20/alpha crystallin family Kinetocho_Slk19 PF12709.2 EWC47105.1 - 5.5e-18 64.8 7.8 5.5e-18 64.8 5.4 4.9 4 1 1 5 5 5 2 Central kinetochore-associated IncA PF04156.9 EWC47105.1 - 0.00018 21.1 35.5 0.00035 20.2 7.1 3.4 2 1 0 2 2 2 1 IncA protein ORF6C PF10552.4 EWC47105.1 - 0.0011 18.6 5.8 0.0052 16.5 0.7 3.0 2 0 0 2 2 2 1 ORF6C domain bZIP_1 PF00170.16 EWC47105.1 - 0.0074 16.2 3.4 0.0074 16.2 2.4 4.8 4 0 0 4 4 4 2 bZIP transcription factor TMF_DNA_bd PF12329.3 EWC47105.1 - 0.01 15.6 45.0 0.017 14.8 0.9 5.3 3 2 2 5 5 5 0 TATA element modulatory factor 1 DNA binding DUF4201 PF13870.1 EWC47105.1 - 0.044 13.2 28.9 1.5 8.2 7.6 3.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4201) Filament PF00038.16 EWC47105.1 - 0.18 11.2 37.7 1.8 7.9 3.3 2.6 1 1 1 2 2 2 0 Intermediate filament protein DUF1192 PF06698.6 EWC47105.1 - 0.49 10.2 11.4 0.44 10.4 2.2 3.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) MscS_porin PF12795.2 EWC47105.1 - 0.53 9.5 32.2 0.13 11.5 8.3 3.7 3 1 0 3 3 3 0 Mechanosensitive ion channel porin domain Reo_sigmaC PF04582.7 EWC47105.1 - 0.88 8.6 12.6 7.3 5.6 0.6 3.6 1 1 2 4 4 4 0 Reovirus sigma C capsid protein WXG100 PF06013.7 EWC47105.1 - 1.1 9.2 21.5 0.44 10.5 0.6 4.4 3 2 1 4 4 4 0 Proteins of 100 residues with WXG DivIC PF04977.10 EWC47105.1 - 1.5 8.3 33.6 1.1 8.7 3.0 5.5 4 2 0 4 4 4 0 Septum formation initiator Myosin_tail_1 PF01576.14 EWC47105.1 - 1.5 6.4 48.9 0.12 10.0 13.0 3.1 1 1 0 2 2 2 0 Myosin tail GAS PF13851.1 EWC47105.1 - 1.7 7.8 37.7 0.16 11.1 1.6 4.0 3 1 0 3 3 3 0 Growth-arrest specific micro-tubule binding Baculo_PEP_C PF04513.7 EWC47105.1 - 1.9 8.3 10.4 5.7 6.7 0.6 3.6 3 1 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1664 PF07889.7 EWC47105.1 - 4 7.2 20.9 1.4 8.6 1.5 4.4 2 2 1 4 4 4 0 Protein of unknown function (DUF1664) DUF2746 PF10874.3 EWC47105.1 - 5.1 7.3 16.0 4.3 7.6 0.4 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2746) Atg14 PF10186.4 EWC47105.1 - 5.3 5.9 34.5 0.06 12.2 2.9 4.0 1 1 1 2 2 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF4391 PF14335.1 EWC47105.1 - 6 6.1 18.5 0.063 12.6 4.1 3.1 4 0 0 4 4 4 0 Domain of unknown function (DUF4391) AAA_13 PF13166.1 EWC47105.1 - 6.7 5.0 36.1 0.89 7.9 12.3 3.0 1 1 2 3 3 3 0 AAA domain DUF972 PF06156.8 EWC47105.1 - 9.5 6.6 29.9 1.7 9.0 0.2 5.0 2 1 2 4 4 4 0 Protein of unknown function (DUF972) Glyoxalase_3 PF13468.1 EWC47106.1 - 6.2e-25 88.1 0.0 1.2e-24 87.1 0.0 1.4 2 0 0 2 2 2 1 Glyoxalase-like domain DUF2910 PF11139.3 EWC47107.1 - 5 6.1 7.7 83 2.2 5.3 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF2910) AA_permease PF00324.16 EWC47109.1 - 2e-87 293.5 33.2 8.1e-87 291.5 23.0 1.7 1 1 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EWC47109.1 - 5.4e-23 81.2 24.0 8.6e-23 80.5 16.6 1.3 1 0 0 1 1 1 1 Amino acid permease DUF2420 PF10336.4 EWC47111.1 - 1.6e-11 43.7 0.0 2.8e-11 43.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2420) Adap_comp_sub PF00928.16 EWC47112.1 - 2e-15 56.6 0.0 3e-15 56.0 0.0 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.15 EWC47112.1 - 1.1e-06 28.4 0.0 1.6e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Mg_trans_NIPA PF05653.9 EWC47113.1 - 3.5e-106 354.5 21.3 4.3e-106 354.2 14.8 1.0 1 0 0 1 1 1 1 Magnesium transporter NIPA EmrE PF13536.1 EWC47113.1 - 6.3e-08 32.8 4.3 6.3e-08 32.8 3.0 3.3 2 1 1 3 3 3 1 Multidrug resistance efflux transporter EamA PF00892.15 EWC47113.1 - 0.00028 20.9 6.7 0.00028 20.9 4.6 3.4 2 2 1 3 3 3 2 EamA-like transporter family GAT PF03127.9 EWC47114.1 - 1.7e-12 47.1 0.1 5.4e-12 45.5 0.0 1.8 2 0 0 2 2 2 1 GAT domain VHS PF00790.14 EWC47114.1 - 0.00021 20.9 0.0 0.00042 19.9 0.0 1.5 1 0 0 1 1 1 1 VHS domain DMAP_binding PF06464.6 EWC47115.1 - 3.1e-12 47.0 0.9 6.5e-12 46.0 0.0 1.9 2 0 0 2 2 2 1 DMAP1-binding Domain GvpG PF05120.7 EWC47115.1 - 6.6e-06 25.8 0.0 4.1e-05 23.2 0.0 2.0 2 0 0 2 2 2 1 Gas vesicle protein G SHOCT PF09851.4 EWC47115.1 - 0.31 10.5 2.7 0.43 10.1 1.9 1.2 1 0 0 1 1 1 0 Short C-terminal domain AMP-binding PF00501.23 EWC47116.1 - 3.1e-57 193.8 2.0 7.9e-25 87.0 0.3 4.5 3 1 0 3 3 3 3 AMP-binding enzyme NRDE-2 PF08424.5 EWC47117.1 - 4.7e-77 259.0 0.0 3e-71 239.9 0.0 3.3 3 0 0 3 3 3 3 NRDE-2, necessary for RNA interference TPR_14 PF13428.1 EWC47117.1 - 0.0002 21.7 2.3 22 6.0 0.0 6.6 6 0 0 6 6 6 1 Tetratricopeptide repeat DUF605 PF04652.11 EWC47118.1 - 8.4 5.6 43.6 1.5 8.1 7.7 2.1 2 0 0 2 2 2 0 Vta1 like DUF4045 PF13254.1 EWC47120.1 - 8.3e-31 107.6 38.5 3.7e-30 105.5 23.0 6.2 3 3 1 5 5 5 2 Domain of unknown function (DUF4045) Gelsolin PF00626.17 EWC47120.1 - 1.1e-10 40.9 0.0 0.024 14.3 0.0 3.8 3 0 0 3 3 3 3 Gelsolin repeat Arf PF00025.16 EWC47121.1 - 2.1e-67 225.7 1.8 2.3e-67 225.5 1.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.15 EWC47121.1 - 4.1e-13 48.7 0.9 5.6e-07 28.5 0.1 2.1 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.17 EWC47121.1 - 6.8e-13 48.3 0.0 7.9e-13 48.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.7 EWC47121.1 - 4e-10 39.2 0.0 4.9e-10 38.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Miro PF08477.8 EWC47121.1 - 1.4e-09 38.4 0.0 2e-09 37.9 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein SRPRB PF09439.5 EWC47121.1 - 6.6e-09 35.2 0.0 7.8e-09 35.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.18 EWC47121.1 - 6.8e-09 35.6 0.0 8.7e-09 35.3 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 EWC47121.1 - 6.4e-07 28.9 0.0 6.9e-05 22.3 0.0 2.0 1 1 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_17 PF13207.1 EWC47121.1 - 0.018 15.8 0.1 0.031 15.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain FeoB_N PF02421.13 EWC47121.1 - 0.033 13.4 0.3 0.085 12.1 0.2 1.8 1 1 0 1 1 1 0 Ferrous iron transport protein B PduV-EutP PF10662.4 EWC47121.1 - 0.09 12.2 0.1 0.31 10.5 0.1 1.9 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_14 PF13173.1 EWC47121.1 - 0.12 12.2 0.0 0.16 11.9 0.0 1.6 1 1 0 1 1 1 0 AAA domain Peptidase_S8 PF00082.17 EWC47122.1 - 7e-27 94.2 0.0 1.5e-26 93.2 0.0 1.5 1 0 0 1 1 1 1 Subtilase family DEAD PF00270.24 EWC47123.1 - 5e-42 143.2 0.1 1.3e-41 141.9 0.1 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EWC47123.1 - 2.6e-25 88.0 0.0 7e-25 86.7 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF1253 PF06862.7 EWC47123.1 - 2e-05 23.1 1.7 0.00025 19.6 0.0 2.8 2 1 1 3 3 3 1 Protein of unknown function (DUF1253) ResIII PF04851.10 EWC47123.1 - 0.084 12.7 0.0 0.084 12.7 0.0 2.8 3 1 0 3 3 3 0 Type III restriction enzyme, res subunit DUF650 PF04894.7 EWC47124.1 - 0.1 12.0 0.0 0.16 11.4 0.0 1.2 1 0 0 1 1 1 0 Archaeal protein of unknown function (DUF650) UBA_4 PF14555.1 EWC47125.1 - 5.7e-11 41.7 0.0 1.1e-10 40.9 0.0 1.5 1 0 0 1 1 1 1 UBA-like domain UBX PF00789.15 EWC47125.1 - 3.4e-08 33.4 0.0 7.1e-08 32.4 0.0 1.5 1 0 0 1 1 1 1 UBX domain ubiquitin PF00240.18 EWC47126.1 - 1.1e-09 37.4 0.0 1.8e-09 36.8 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 EWC47126.1 - 0.039 13.6 0.0 0.073 12.7 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.1 EWC47126.1 - 0.13 12.1 0.0 0.25 11.2 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like zf-Mss51 PF13824.1 EWC47127.1 - 9.9e-22 76.5 8.4 9.9e-22 76.5 5.8 2.2 3 0 0 3 3 3 1 Zinc-finger of mitochondrial splicing suppressor 51 zf-MYND PF01753.13 EWC47127.1 - 0.27 11.1 3.6 0.43 10.4 2.5 1.3 1 0 0 1 1 1 0 MYND finger HSP70 PF00012.15 EWC47128.1 - 9e-57 192.3 0.2 9e-57 192.3 0.1 3.6 3 1 0 3 3 3 2 Hsp70 protein MreB_Mbl PF06723.8 EWC47128.1 - 2.1e-05 23.2 0.2 0.00056 18.6 0.5 2.7 3 0 0 3 3 3 1 MreB/Mbl protein Spc7 PF08317.6 EWC47128.1 - 0.52 8.9 10.3 0.039 12.6 3.1 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein DUF2347 PF09804.4 EWC47129.1 - 3.7e-67 226.5 0.0 7.2e-66 222.3 0.0 2.1 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2347) DUF4484 PF14831.1 EWC47129.1 - 4.2e-32 111.6 0.0 7e-32 110.9 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4484) Macoilin PF09726.4 EWC47131.1 - 0.15 10.3 11.9 0.2 9.9 8.3 1.2 1 0 0 1 1 1 0 Transmembrane protein Rab5-bind PF09311.6 EWC47131.1 - 0.36 10.7 4.5 2.8 7.7 0.2 2.2 2 0 0 2 2 2 0 Rabaptin-like protein DUF572 PF04502.8 EWC47131.1 - 0.52 9.4 11.5 2.5 7.2 5.6 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF572) Peptidase_S64 PF08192.6 EWC47131.1 - 2.9 6.1 10.2 3.6 5.7 7.1 1.1 1 0 0 1 1 1 0 Peptidase family S64 DNA_pol_viral_N PF00242.12 EWC47131.1 - 9.8 5.0 16.1 18 4.2 11.2 1.4 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain Peptidase_M24 PF00557.19 EWC47132.1 - 5.3e-58 196.0 0.1 8.3e-58 195.3 0.1 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.11 EWC47132.1 - 3.6e-21 74.9 0.0 1.4e-20 73.0 0.0 1.9 2 0 0 2 2 2 1 Aminopeptidase P, N-terminal domain LSM PF01423.17 EWC47133.1 - 2.9e-15 55.5 0.1 3.6e-15 55.2 0.1 1.1 1 0 0 1 1 1 1 LSM domain Pkinase PF00069.20 EWC47134.1 - 6.8e-06 25.4 0.0 1.3e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain DnaJ PF00226.26 EWC47135.1 - 1.1e-21 76.3 0.0 1.8e-21 75.6 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain DUF605 PF04652.11 EWC47135.1 - 0.13 11.6 14.5 0.17 11.2 10.1 1.1 1 0 0 1 1 1 0 Vta1 like Apc4 PF12896.2 EWC47136.1 - 8.9e-48 162.3 0.1 1.5e-47 161.5 0.0 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 4 Apc4_WD40 PF12894.2 EWC47136.1 - 1.3e-14 53.4 0.2 1.3e-13 50.1 0.0 2.7 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.27 EWC47136.1 - 0.064 13.1 0.0 0.59 10.1 0.0 2.6 3 0 0 3 3 3 0 WD domain, G-beta repeat HEAT_EZ PF13513.1 EWC47137.1 - 6e-18 64.7 11.6 1.6e-07 31.6 0.0 8.9 9 2 1 10 10 8 4 HEAT-like repeat HEAT PF02985.17 EWC47137.1 - 1.3e-16 59.1 16.7 4.2e-05 23.2 0.1 11.2 12 1 0 12 12 12 3 HEAT repeat HEAT_2 PF13646.1 EWC47137.1 - 1.7e-14 53.8 16.0 2.3e-06 27.7 0.0 7.4 3 2 4 7 7 7 6 HEAT repeats IBN_N PF03810.14 EWC47137.1 - 2e-08 34.0 4.4 2.7e-07 30.4 0.5 3.6 4 0 0 4 4 4 1 Importin-beta N-terminal domain CLASP_N PF12348.3 EWC47137.1 - 3.1e-06 26.7 0.1 0.0012 18.2 0.0 3.9 3 2 1 4 4 4 1 CLASP N terminal Adaptin_N PF01602.15 EWC47137.1 - 0.00023 19.6 1.6 6.3 4.9 0.0 4.5 2 1 1 4 4 4 2 Adaptin N terminal region Arm PF00514.18 EWC47137.1 - 0.00038 20.1 8.3 1.2 9.1 0.0 6.0 6 0 0 6 6 6 1 Armadillo/beta-catenin-like repeat Imm27 PF15573.1 EWC47137.1 - 0.034 13.3 0.1 0.069 12.3 0.1 1.5 1 0 0 1 1 1 0 Immunity protein 27 DUF1981 PF09324.5 EWC47137.1 - 0.035 13.6 0.1 2.8 7.5 0.0 3.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1981) TIP120 PF08623.5 EWC47137.1 - 0.051 13.1 0.0 6.5 6.3 0.0 4.0 4 1 1 5 5 5 0 TATA-binding protein interacting (TIP20) ADSL_C PF10397.4 EWC47137.1 - 0.06 13.3 0.1 0.41 10.7 0.1 2.4 2 0 0 2 2 2 0 Adenylosuccinate lyase C-terminus Xpo1 PF08389.7 EWC47137.1 - 0.2 11.5 11.3 4.9 7.0 0.1 6.0 5 2 2 7 7 7 0 Exportin 1-like protein HEAT_PBS PF03130.11 EWC47137.1 - 1.2 9.8 11.2 37 5.1 0.0 6.9 8 0 0 8 8 7 0 PBS lyase HEAT-like repeat CPSF_A PF03178.10 EWC47138.1 - 1.9e-99 332.8 0.0 1.1e-96 323.7 0.0 3.2 3 0 0 3 3 3 1 CPSF A subunit region MMS1_N PF10433.4 EWC47138.1 - 7.4e-68 228.9 0.0 1.4e-67 228.0 0.0 1.4 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term BBS2_Mid PF14783.1 EWC47138.1 - 0.028 14.1 0.0 13 5.6 0.0 4.4 4 0 0 4 4 4 0 Ciliary BBSome complex subunit 2, middle region WD40 PF00400.27 EWC47138.1 - 0.47 10.4 4.7 0.4 10.6 0.1 3.4 4 0 0 4 4 4 0 WD domain, G-beta repeat PS_Dcarbxylase PF02666.10 EWC47139.1 - 1.2e-70 236.9 0.0 3.7e-70 235.3 0.0 1.8 2 1 0 2 2 2 1 Phosphatidylserine decarboxylase F-box-like PF12937.2 EWC47140.1 - 0.00074 19.1 1.1 0.00074 19.1 0.8 2.7 3 0 0 3 3 3 1 F-box-like F-box PF00646.28 EWC47140.1 - 0.45 10.2 5.0 0.12 12.0 0.8 2.0 2 1 0 2 2 2 0 F-box domain LysM PF01476.15 EWC47141.1 - 0.071 13.0 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 LysM domain UBA_4 PF14555.1 EWC47141.1 - 0.16 11.5 0.8 0.3 10.6 0.6 1.4 1 0 0 1 1 1 0 UBA-like domain BP28CT PF08146.7 EWC47142.1 - 1.5e-29 102.7 0.1 3.3e-29 101.5 0.1 1.7 1 0 0 1 1 1 1 BP28CT (NUC211) domain U3snoRNP10 PF12397.3 EWC47142.1 - 2.3e-18 66.2 2.1 2.3e-18 66.2 1.4 4.6 5 0 0 5 5 5 1 U3 small nucleolar RNA-associated protein 10 HEAT PF02985.17 EWC47142.1 - 1.1e-06 28.1 9.0 0.016 15.2 0.0 6.7 6 0 0 6 6 6 2 HEAT repeat Adaptin_N PF01602.15 EWC47142.1 - 3.4e-06 25.6 1.5 0.78 7.9 0.0 4.2 5 0 0 5 5 5 3 Adaptin N terminal region Vac14_Fab1_bd PF12755.2 EWC47142.1 - 0.0045 17.3 0.0 0.48 10.8 0.0 3.2 2 1 1 3 3 3 1 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.1 EWC47142.1 - 0.01 16.3 30.5 0.16 12.4 0.0 8.3 9 0 0 9 9 9 0 HEAT-like repeat HEAT_EZ PF13513.1 EWC47143.1 - 7.5e-26 89.9 12.0 5.2e-12 45.8 0.0 11.4 9 3 6 15 15 15 3 HEAT-like repeat HEAT PF02985.17 EWC47143.1 - 9.6e-24 81.3 13.9 0.00016 21.4 0.0 10.9 12 0 0 12 12 12 3 HEAT repeat HEAT_2 PF13646.1 EWC47143.1 - 1.3e-22 79.8 1.0 5.2e-06 26.6 0.0 8.4 3 3 5 9 9 9 6 HEAT repeats Vac14_Fab1_bd PF12755.2 EWC47143.1 - 1.3e-10 41.5 0.0 0.0018 18.6 0.0 5.6 3 2 1 6 6 6 2 Vacuolar 14 Fab1-binding region IBN_N PF03810.14 EWC47143.1 - 1.5e-07 31.2 0.2 1.6e-05 24.7 0.0 4.3 4 0 0 4 4 4 1 Importin-beta N-terminal domain RIX1 PF08167.7 EWC47143.1 - 2.7e-07 30.3 0.7 0.38 10.4 0.0 5.7 4 3 1 5 5 5 2 rRNA processing/ribosome biogenesis Adaptin_N PF01602.15 EWC47143.1 - 3e-07 29.1 0.1 0.0014 17.0 0.0 3.9 3 2 1 4 4 4 2 Adaptin N terminal region CLASP_N PF12348.3 EWC47143.1 - 1.5e-06 27.7 0.5 3.1 7.1 0.0 6.7 5 2 0 6 6 6 1 CLASP N terminal Cnd1 PF12717.2 EWC47143.1 - 3.8e-05 23.6 1.1 3 7.6 0.0 5.1 5 1 0 5 5 5 1 non-SMC mitotic condensation complex subunit 1 Arm PF00514.18 EWC47143.1 - 0.00014 21.5 2.5 0.61 9.9 0.0 5.3 6 0 0 6 6 5 1 Armadillo/beta-catenin-like repeat MMS19_C PF12460.3 EWC47143.1 - 0.0013 17.5 0.0 1.4 7.6 0.1 4.4 5 1 0 5 5 5 1 RNAPII transcription regulator C-terminal DUF1981 PF09324.5 EWC47143.1 - 0.0054 16.2 0.2 1 8.9 0.0 4.0 4 0 0 4 4 4 1 Domain of unknown function (DUF1981) DUF3437 PF11919.3 EWC47143.1 - 0.013 15.1 0.2 4.5 7.0 0.0 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF3437) HEAT_PBS PF03130.11 EWC47143.1 - 0.093 13.2 5.3 32 5.3 0.0 6.4 6 1 0 6 6 5 0 PBS lyase HEAT-like repeat Ribosomal_S8 PF00410.14 EWC47144.1 - 1.3e-24 86.4 0.0 1.7e-24 86.0 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S8 SNF2_N PF00176.18 EWC47145.1 - 4.4e-63 212.8 0.0 6.3e-63 212.3 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 EWC47145.1 - 3.8e-13 49.1 0.0 7.7e-13 48.1 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HDA2-3 PF11496.3 EWC47145.1 - 4e-07 29.1 0.6 2.5e-06 26.5 0.4 2.0 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 DEAD PF00270.24 EWC47145.1 - 3.1e-06 26.7 0.0 5.7e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 EWC47145.1 - 1.6e-05 24.8 0.0 8e-05 22.5 0.0 2.2 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.1 EWC47145.1 - 0.0035 17.4 0.2 0.015 15.4 0.0 2.2 2 1 0 2 2 2 1 AAA domain DUF2075 PF09848.4 EWC47145.1 - 0.093 11.6 0.0 0.28 10.0 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) UvrD-helicase PF00580.16 EWC47146.1 - 3.8e-13 49.4 0.4 5.2e-07 29.2 0.0 2.7 2 0 0 2 2 2 2 UvrD/REP helicase N-terminal domain UvrD_C_2 PF13538.1 EWC47146.1 - 1.3e-06 28.4 0.0 3.3e-06 27.1 0.0 1.7 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain UvrD_C PF13361.1 EWC47146.1 - 2.4e-05 23.9 0.2 6.3e-05 22.5 0.0 1.7 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain AAA_19 PF13245.1 EWC47146.1 - 4.1e-05 23.2 0.0 0.0015 18.1 0.0 2.6 2 0 0 2 2 2 1 Part of AAA domain Viral_helicase1 PF01443.13 EWC47146.1 - 0.00011 21.8 0.6 0.69 9.3 0.1 3.3 2 1 0 2 2 2 2 Viral (Superfamily 1) RNA helicase ResIII PF04851.10 EWC47146.1 - 0.00023 21.0 0.0 0.00068 19.5 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.1 EWC47146.1 - 0.00078 19.0 0.0 0.0024 17.4 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.1 EWC47146.1 - 0.002 18.2 0.1 0.015 15.3 0.1 2.4 1 1 0 1 1 1 1 AAA domain PhoH PF02562.11 EWC47146.1 - 0.013 14.7 0.1 0.065 12.4 0.0 2.0 2 0 0 2 2 2 0 PhoH-like protein DEAD PF00270.24 EWC47146.1 - 0.02 14.3 0.2 0.073 12.5 0.1 2.1 1 1 0 1 1 1 0 DEAD/DEAH box helicase AAA_25 PF13481.1 EWC47146.1 - 0.028 13.8 0.0 0.093 12.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain T2SE PF00437.15 EWC47146.1 - 0.037 12.9 0.0 0.065 12.1 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein Syja_N PF02383.13 EWC47147.1 - 6.2e-93 311.0 0.0 1e-92 310.3 0.0 1.4 1 0 0 1 1 1 1 SacI homology domain hSac2 PF12456.3 EWC47147.1 - 1.5e-34 117.8 0.0 3.3e-34 116.7 0.0 1.6 1 0 0 1 1 1 1 Inositol phosphatase AAA_2 PF07724.9 EWC47149.1 - 3.8e-52 176.6 1.0 1.2e-49 168.4 0.0 3.7 4 0 0 4 4 3 1 AAA domain (Cdc48 subfamily) AAA PF00004.24 EWC47149.1 - 3.5e-29 101.6 0.0 3.3e-16 59.6 0.0 2.8 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.4 EWC47149.1 - 2.8e-21 75.1 0.3 2.8e-21 75.1 0.2 2.8 3 0 0 3 3 2 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.9 EWC47149.1 - 1.6e-17 63.5 0.1 2.4e-11 43.5 0.0 3.2 3 0 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 EWC47149.1 - 2.6e-14 53.4 0.7 2e-05 24.7 0.0 3.9 2 2 2 4 4 4 2 AAA domain AAA_16 PF13191.1 EWC47149.1 - 2.5e-13 50.4 8.2 3.4e-05 23.9 0.0 5.6 3 3 1 4 4 3 2 AAA ATPase domain Sigma54_activat PF00158.21 EWC47149.1 - 4.7e-11 42.4 0.0 8.3e-07 28.6 0.0 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain IstB_IS21 PF01695.12 EWC47149.1 - 5.1e-09 35.7 0.0 0.0011 18.4 0.0 2.6 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_17 PF13207.1 EWC47149.1 - 8e-08 33.1 8.5 0.0035 18.1 0.0 3.9 2 2 0 2 2 2 2 AAA domain AAA_14 PF13173.1 EWC47149.1 - 1.4e-07 31.4 0.0 0.017 14.9 0.0 3.2 3 0 0 3 3 2 2 AAA domain Mg_chelatase PF01078.16 EWC47149.1 - 5.7e-07 28.9 0.3 0.014 14.5 0.1 3.5 2 1 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_19 PF13245.1 EWC47149.1 - 4.8e-06 26.2 0.0 0.21 11.3 0.0 3.1 2 0 0 2 2 2 2 Part of AAA domain AAA_24 PF13479.1 EWC47149.1 - 2.4e-05 24.0 0.0 0.13 11.7 0.0 2.5 2 0 0 2 2 2 2 AAA domain RuvB_N PF05496.7 EWC47149.1 - 2.8e-05 23.2 1.0 0.27 10.2 0.6 3.5 2 1 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_33 PF13671.1 EWC47149.1 - 3.8e-05 23.5 0.0 0.053 13.3 0.0 2.9 2 0 0 2 2 2 1 AAA domain Sigma54_activ_2 PF14532.1 EWC47149.1 - 4.8e-05 23.4 0.0 0.38 10.7 0.0 3.3 2 1 0 2 2 2 2 Sigma-54 interaction domain RNA_helicase PF00910.17 EWC47149.1 - 7e-05 22.9 0.0 0.25 11.5 0.0 2.6 2 0 0 2 2 2 2 RNA helicase AAA_18 PF13238.1 EWC47149.1 - 8.8e-05 22.8 13.2 0.0045 17.3 0.0 4.3 3 3 1 4 4 2 2 AAA domain Arch_ATPase PF01637.13 EWC47149.1 - 8.9e-05 22.2 8.9 0.2 11.3 0.0 5.0 4 1 0 4 4 4 2 Archaeal ATPase Zeta_toxin PF06414.7 EWC47149.1 - 0.00013 21.1 0.0 0.082 12.0 0.0 3.0 2 0 0 2 2 2 1 Zeta toxin AAA_25 PF13481.1 EWC47149.1 - 0.00033 20.1 0.5 2.4 7.5 0.0 4.1 3 1 1 4 4 4 1 AAA domain AAA_28 PF13521.1 EWC47149.1 - 0.00048 20.1 0.5 2.4 8.0 0.0 3.6 3 1 1 4 4 4 2 AAA domain NACHT PF05729.7 EWC47149.1 - 0.00063 19.4 0.0 1.2 8.7 0.0 3.3 3 0 0 3 3 3 1 NACHT domain Torsin PF06309.6 EWC47149.1 - 0.0007 19.4 0.0 0.026 14.3 0.0 2.5 2 0 0 2 2 2 1 Torsin MobB PF03205.9 EWC47149.1 - 0.00094 18.9 0.0 0.56 9.9 0.0 2.8 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_3 PF07726.6 EWC47149.1 - 0.0011 18.5 0.0 4.1 7.0 0.0 3.5 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) Clp_N PF02861.15 EWC47149.1 - 0.005 16.7 2.7 0.034 14.0 0.1 3.3 3 0 0 3 3 2 1 Clp amino terminal domain Peptidase_M16 PF00675.15 EWC47149.1 - 0.0073 16.0 1.0 0.19 11.5 0.5 2.7 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) DUF258 PF03193.11 EWC47149.1 - 0.0076 15.4 0.0 1.8 7.7 0.0 2.6 2 0 0 2 2 2 1 Protein of unknown function, DUF258 ResIII PF04851.10 EWC47149.1 - 0.008 16.0 0.0 6.7 6.5 0.0 3.6 2 1 1 3 3 3 0 Type III restriction enzyme, res subunit AAA_10 PF12846.2 EWC47149.1 - 0.0098 15.3 6.9 2 7.7 0.0 5.1 5 1 0 5 5 5 1 AAA-like domain ABC_tran PF00005.22 EWC47149.1 - 0.014 15.6 1.7 2.6 8.3 0.0 3.6 3 0 0 3 3 3 0 ABC transporter PhoH PF02562.11 EWC47149.1 - 0.02 14.1 0.0 0.81 8.8 0.0 2.6 2 0 0 2 2 2 0 PhoH-like protein V_ATPase_I PF01496.14 EWC47149.1 - 0.27 9.0 5.9 0.48 8.2 4.1 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family AAA_23 PF13476.1 EWC47149.1 - 0.56 10.5 0.0 0.56 10.5 0.0 4.4 3 1 0 3 3 2 0 AAA domain Pro_CA PF00484.14 EWC47149.1 - 2.8 7.9 5.9 2.8 7.9 1.8 2.6 2 1 1 3 3 3 0 Carbonic anhydrase APG6 PF04111.7 EWC47149.1 - 2.9 6.8 9.8 6 5.8 6.8 1.6 1 0 0 1 1 1 0 Autophagy protein Apg6 DnaJ PF00226.26 EWC47150.1 - 1.5e-18 66.2 0.0 2.9e-18 65.3 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain DUF1777 PF08648.7 EWC47150.1 - 0.15 11.7 27.7 0.23 11.2 19.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1777) DUF605 PF04652.11 EWC47150.1 - 0.42 9.9 14.4 0.5 9.7 10.0 1.1 1 0 0 1 1 1 0 Vta1 like MIP-T3 PF10243.4 EWC47150.1 - 0.51 8.7 27.5 0.63 8.4 19.1 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Hid1 PF12722.2 EWC47150.1 - 0.75 7.3 10.7 0.9 7.1 7.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Gar1 PF04410.9 EWC47150.1 - 1.1 8.6 5.4 0.23 10.9 1.2 1.7 1 1 1 2 2 2 0 Gar1/Naf1 RNA binding region AAA_11 PF13086.1 EWC47150.1 - 1.6 8.2 6.1 2.3 7.7 4.2 1.2 1 0 0 1 1 1 0 AAA domain DUF1510 PF07423.6 EWC47150.1 - 2.2 7.6 14.9 3.1 7.1 10.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Ycf1 PF05758.7 EWC47150.1 - 3.2 5.3 9.3 3.6 5.1 6.5 1.1 1 0 0 1 1 1 0 Ycf1 DDRGK PF09756.4 EWC47150.1 - 3.6 6.9 27.3 5.7 6.3 19.0 1.2 1 0 0 1 1 1 0 DDRGK domain SAPS PF04499.10 EWC47150.1 - 4 5.9 8.4 4.5 5.7 5.8 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Neur_chan_memb PF02932.11 EWC47150.1 - 4.6 7.0 6.3 6.3 6.5 4.3 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region NARP1 PF12569.3 EWC47150.1 - 5.4 5.6 12.4 7.5 5.1 8.6 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF4629 PF15442.1 EWC47150.1 - 5.8 7.0 16.2 2 8.5 9.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4629) IBR PF01485.16 EWC47152.1 - 1.6e-06 27.8 8.3 1.6e-06 27.8 5.7 4.8 4 1 0 4 4 4 3 IBR domain PTR2 PF00854.16 EWC47154.1 - 8e-45 153.2 15.1 2.2e-44 151.7 10.5 1.7 1 1 0 1 1 1 1 POT family DUF3040 PF11239.3 EWC47154.1 - 5.4 7.1 7.2 1.9 8.5 1.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3040) Glyco_hydro_16 PF00722.16 EWC47155.1 - 2.9e-11 42.9 0.0 4.9e-11 42.2 0.0 1.3 1 1 0 1 1 1 1 Glycosyl hydrolases family 16 DUF2235 PF09994.4 EWC47156.1 - 1.7e-65 221.1 0.0 2.5e-65 220.5 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) Zn_clus PF00172.13 EWC47158.1 - 0.069 13.0 10.1 0.14 12.0 7.0 1.5 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-C5HC2 PF02928.11 EWC47158.1 - 0.63 10.1 5.5 7.9 6.6 2.4 2.4 2 0 0 2 2 2 0 C5HC2 zinc finger Citrate_synt PF00285.16 EWC47159.1 - 0.047 12.4 0.0 0.052 12.2 0.0 1.1 1 0 0 1 1 1 0 Citrate synthase Mito_carr PF00153.22 EWC47160.1 - 1.5e-42 143.1 10.9 1.4e-18 66.3 0.4 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein HTH_IclR PF09339.5 EWC47160.1 - 0.054 13.1 0.0 0.15 11.6 0.0 1.7 2 0 0 2 2 2 0 IclR helix-turn-helix domain 4HBT_3 PF13622.1 EWC47162.1 - 2.9e-48 164.8 0.6 2.9e-48 164.8 0.4 1.5 2 0 0 2 2 2 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.10 EWC47162.1 - 6.8e-27 93.6 0.0 7.5e-23 80.6 0.0 2.4 2 1 0 2 2 2 2 Acyl-CoA thioesterase 4HBT PF03061.17 EWC47162.1 - 0.0037 17.3 0.1 0.26 11.4 0.0 2.3 2 0 0 2 2 2 1 Thioesterase superfamily HK PF02110.10 EWC47164.1 - 9.6e-75 250.9 2.4 1.3e-74 250.4 1.7 1.2 1 0 0 1 1 1 1 Hydroxyethylthiazole kinase family TMP-TENI PF02581.12 EWC47164.1 - 1.2e-59 200.4 0.0 1.9e-59 199.8 0.0 1.3 1 0 0 1 1 1 1 Thiamine monophosphate synthase/TENI Phos_pyr_kin PF08543.7 EWC47164.1 - 0.001 18.3 0.3 0.0078 15.4 0.0 2.1 1 1 1 2 2 2 1 Phosphomethylpyrimidine kinase PfkB PF00294.19 EWC47164.1 - 0.0057 15.8 0.0 0.018 14.1 0.0 1.8 3 0 0 3 3 3 1 pfkB family carbohydrate kinase Asp PF00026.18 EWC47165.1 - 1.6e-14 53.8 0.0 4.6e-14 52.3 0.0 1.8 1 1 0 1 1 1 1 Eukaryotic aspartyl protease Herpes_gE PF02480.11 EWC47165.1 - 0.0068 14.7 0.1 0.02 13.1 0.1 1.7 2 0 0 2 2 2 1 Alphaherpesvirus glycoprotein E Mid2 PF04478.7 EWC47165.1 - 0.0097 15.3 3.9 0.017 14.5 0.3 2.4 2 0 0 2 2 2 1 Mid2 like cell wall stress sensor Nop25 PF09805.4 EWC47165.1 - 0.0097 15.9 1.2 0.017 15.1 0.8 1.3 1 0 0 1 1 1 1 Nucleolar protein 12 (25kDa) TMEM154 PF15102.1 EWC47165.1 - 0.011 15.4 0.1 0.024 14.3 0.0 1.5 1 0 0 1 1 1 0 TMEM154 protein family Podoplanin PF05808.6 EWC47165.1 - 0.046 13.2 4.8 0.13 11.8 3.3 1.7 1 0 0 1 1 1 0 Podoplanin Anp1 PF03452.9 EWC47166.1 - 1.5e-18 66.9 0.0 3.1e-11 42.9 0.0 2.3 2 0 0 2 2 2 2 Anp1 Amidohydro_2 PF04909.9 EWC47167.1 - 1.6e-18 67.2 2.7 2.9e-18 66.4 1.9 1.4 1 1 0 1 1 1 1 Amidohydrolase JHBP PF06585.6 EWC47167.1 - 0.21 10.3 0.0 0.33 9.7 0.0 1.2 1 0 0 1 1 1 0 Haemolymph juvenile hormone binding protein (JHBP) Phos_pyr_kin PF08543.7 EWC47168.1 - 1.4e-83 279.8 5.2 1.9e-83 279.4 3.6 1.2 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase TENA_THI-4 PF03070.11 EWC47168.1 - 7.9e-40 136.8 0.1 1.1e-39 136.4 0.1 1.2 1 0 0 1 1 1 1 TENA/THI-4/PQQC family PfkB PF00294.19 EWC47168.1 - 0.00068 18.8 1.7 0.0012 18.0 1.1 1.4 1 0 0 1 1 1 1 pfkB family carbohydrate kinase GYD PF08734.6 EWC47168.1 - 0.29 10.9 2.0 0.52 10.0 0.1 2.3 2 0 0 2 2 2 0 GYD domain Fungal_trans PF04082.13 EWC47169.1 - 6.8e-22 77.5 0.4 1.4e-21 76.5 0.3 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EWC47169.1 - 6.5e-07 29.1 8.5 6.5e-07 29.1 5.9 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DYW_deaminase PF14432.1 EWC47170.1 - 1e-05 25.5 0.1 2.1e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 DYW family of nucleic acid deaminases GFO_IDH_MocA PF01408.17 EWC47171.1 - 2e-21 76.7 0.0 3.4e-21 75.9 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.12 EWC47171.1 - 7.2e-07 29.0 0.0 1.6e-06 27.8 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain NAD_binding_3 PF03447.11 EWC47171.1 - 0.014 15.7 0.0 0.03 14.7 0.0 1.5 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain Semialdhyde_dh PF01118.19 EWC47171.1 - 0.043 14.1 0.0 0.083 13.1 0.0 1.5 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain EBP PF05241.7 EWC47172.1 - 1.1e-66 223.6 10.4 1.3e-66 223.3 7.2 1.0 1 0 0 1 1 1 1 Emopamil binding protein ESSS PF10183.4 EWC47172.1 - 2.3 8.6 4.9 0.48 10.8 0.3 2.1 2 2 0 2 2 2 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) N2227 PF07942.7 EWC47173.1 - 1.4e-88 296.4 0.0 4e-88 294.9 0.0 1.7 1 1 0 1 1 1 1 N2227-like protein Methyltransf_23 PF13489.1 EWC47173.1 - 0.0037 16.9 0.0 0.021 14.5 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EWC47173.1 - 0.037 14.4 0.0 0.29 11.6 0.0 2.5 2 0 0 2 2 2 0 Methyltransferase domain DUF1108 PF06531.6 EWC47173.1 - 0.066 13.3 0.2 0.35 11.0 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1108) PAP_central PF04928.12 EWC47174.1 - 1.1e-104 348.7 0.0 1.6e-104 348.2 0.0 1.3 1 0 0 1 1 1 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.10 EWC47174.1 - 2.4e-36 124.6 0.0 4.1e-36 123.8 0.0 1.4 1 0 0 1 1 1 1 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.18 EWC47174.1 - 7.6e-08 32.5 0.0 2.2e-07 31.1 0.0 1.8 1 0 0 1 1 1 1 Nucleotidyltransferase domain FTR1 PF03239.9 EWC47178.1 - 1.9e-82 276.6 8.8 2.3e-82 276.4 6.1 1.0 1 0 0 1 1 1 1 Iron permease FTR1 family DUF4231 PF14015.1 EWC47178.1 - 0.072 13.0 0.4 0.23 11.4 0.3 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF4231) DUF373 PF04123.8 EWC47178.1 - 8.2 5.3 7.4 0.79 8.6 1.6 1.8 2 1 0 2 2 2 0 Domain of unknown function (DUF373) DUF3169 PF11368.3 EWC47178.1 - 9.1 5.3 10.5 1.1 8.3 0.4 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF3169) Cu-oxidase_3 PF07732.10 EWC47179.1 - 1.9e-45 153.3 1.2 1.3e-40 137.7 0.1 3.2 3 0 0 3 3 3 2 Multicopper oxidase Cu-oxidase_2 PF07731.9 EWC47179.1 - 2.7e-42 143.5 3.4 2.1e-37 127.7 0.2 3.4 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.17 EWC47179.1 - 3.1e-38 131.1 0.5 1.9e-31 109.0 0.0 3.2 3 1 0 3 3 3 2 Multicopper oxidase Cupredoxin_1 PF13473.1 EWC47179.1 - 0.00027 20.7 0.0 0.48 10.3 0.0 3.4 3 0 0 3 3 3 2 Cupredoxin-like domain PPC PF04151.10 EWC47179.1 - 0.021 15.8 0.0 0.43 11.5 0.0 2.8 2 0 0 2 2 2 0 Bacterial pre-peptidase C-terminal domain DEAD PF00270.24 EWC47180.1 - 2.7e-34 118.0 0.0 5.3e-34 117.1 0.0 1.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EWC47180.1 - 7.1e-19 67.4 0.3 1.6e-18 66.3 0.1 1.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 EWC47180.1 - 5.1e-07 29.6 0.0 1.2e-06 28.5 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SNF2_N PF00176.18 EWC47180.1 - 0.00067 18.5 0.0 0.0011 17.8 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain UvrD-helicase PF00580.16 EWC47180.1 - 0.054 12.7 0.2 0.089 12.0 0.1 1.3 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain PIGA PF08288.7 EWC47181.1 - 1.3e-46 156.9 0.8 3.8e-45 152.1 0.1 2.3 2 0 0 2 2 2 1 PIGA (GPI anchor biosynthesis) Glycos_transf_1 PF00534.15 EWC47181.1 - 9.6e-29 99.9 0.0 1.3e-28 99.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.1 EWC47181.1 - 7.6e-16 58.6 0.0 1.3e-15 57.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_transf_4 PF13439.1 EWC47181.1 - 3.5e-15 56.1 0.1 6.1e-15 55.3 0.1 1.4 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.1 EWC47181.1 - 3.4e-12 46.6 0.0 7.6e-12 45.5 0.0 1.5 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_4_2 PF13477.1 EWC47181.1 - 9.3e-08 31.9 0.1 1.7e-07 31.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase 4-like Glyco_trans_1_2 PF13524.1 EWC47181.1 - 0.0075 16.5 0.0 0.018 15.2 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferases group 1 AT_hook PF02178.14 EWC47182.1 - 0.68 9.7 6.4 1.6 8.6 3.5 2.3 2 0 0 2 2 2 0 AT hook motif HMGL-like PF00682.14 EWC47185.1 - 2.9e-66 223.5 0.0 5.7e-66 222.5 0.0 1.5 1 0 0 1 1 1 1 HMGL-like LeuA_dimer PF08502.5 EWC47185.1 - 6.1e-21 74.5 0.7 2.5e-20 72.6 0.5 1.9 1 1 0 1 1 1 1 LeuA allosteric (dimerisation) domain DUF2408 PF10303.4 EWC47187.1 - 7.7e-30 103.7 1.0 2.1e-24 86.1 0.0 3.0 2 1 1 3 3 3 3 Protein of unknown function (DUF2408) DUF972 PF06156.8 EWC47187.1 - 0.043 14.1 0.1 3.9 7.8 0.0 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF972) DUF948 PF06103.6 EWC47187.1 - 0.083 12.7 0.1 15 5.5 0.0 2.9 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF4130 PF13566.1 EWC47187.1 - 0.12 11.9 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4130 DASH_Dad3 PF08656.5 EWC47187.1 - 0.49 10.1 5.4 8.2 6.2 0.1 3.5 3 1 1 4 4 4 0 DASH complex subunit Dad3 Ribosomal_60s PF00428.14 EWC47188.1 - 1e-15 57.8 15.9 2.7e-09 37.2 0.2 2.1 1 1 1 2 2 2 2 60s Acidic ribosomal protein Vert_HS_TF PF06546.6 EWC47188.1 - 0.024 14.0 0.1 0.03 13.7 0.0 1.0 1 0 0 1 1 1 0 Vertebrate heat shock transcription factor PKI PF02827.11 EWC47188.1 - 0.64 10.1 3.0 5.3 7.2 0.8 2.2 2 0 0 2 2 2 0 cAMP-dependent protein kinase inhibitor Pyr_redox_2 PF07992.9 EWC47189.1 - 1.2e-39 136.2 0.9 1.8e-39 135.7 0.3 1.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.17 EWC47189.1 - 9.8e-34 115.6 0.2 1.9e-33 114.8 0.1 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.22 EWC47189.1 - 4.7e-17 62.1 10.5 3.2e-15 56.2 0.1 2.9 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 EWC47189.1 - 3.7e-10 40.2 0.1 1.2e-09 38.5 0.0 1.8 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 EWC47189.1 - 1.5e-08 34.1 0.1 1.9e-08 33.8 0.1 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 EWC47189.1 - 2.5e-05 23.3 7.5 0.0011 17.9 2.1 3.1 3 0 0 3 3 3 1 FAD binding domain Thi4 PF01946.12 EWC47189.1 - 6.2e-05 22.1 0.3 0.00012 21.2 0.2 1.5 1 0 0 1 1 1 1 Thi4 family NAD_binding_8 PF13450.1 EWC47189.1 - 7.8e-05 22.6 3.1 0.00021 21.2 2.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.1 EWC47189.1 - 0.00063 18.7 0.0 0.0021 17.0 0.0 1.7 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.9 EWC47189.1 - 0.00086 17.8 1.2 0.016 13.7 0.3 2.5 3 0 0 3 3 3 1 HI0933-like protein DAO PF01266.19 EWC47189.1 - 0.0011 17.9 3.6 0.0016 17.3 2.0 1.7 1 1 1 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.17 EWC47189.1 - 0.012 14.5 3.8 0.049 12.4 2.5 2.0 1 1 0 1 1 1 0 Glucose inhibited division protein A AlaDh_PNT_C PF01262.16 EWC47189.1 - 0.034 13.7 0.1 4.3 6.8 0.0 2.5 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain 3HCDH_N PF02737.13 EWC47189.1 - 3.3 7.3 7.5 1.5 8.4 0.0 2.8 3 0 0 3 3 3 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF3040 PF11239.3 EWC47190.1 - 0.024 14.6 0.0 0.05 13.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) Mid2 PF04478.7 EWC47190.1 - 0.062 12.7 0.4 0.12 11.8 0.3 1.6 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor Asn_synthase PF00733.16 EWC47191.1 - 3.3e-69 233.2 0.0 4.5e-69 232.7 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.1 EWC47191.1 - 3.1e-36 123.8 0.0 4.9e-36 123.2 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.1 EWC47191.1 - 1.4e-29 102.7 0.0 2.5e-29 101.9 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.3 EWC47191.1 - 3.2e-08 33.0 0.0 5.6e-08 32.2 0.0 1.3 1 0 0 1 1 1 1 Aluminium induced protein GATase_2 PF00310.16 EWC47191.1 - 0.0002 20.1 0.0 0.092 11.4 0.0 2.9 1 1 2 3 3 3 2 Glutamine amidotransferases class-II NAD_synthase PF02540.12 EWC47191.1 - 0.096 11.5 0.0 0.16 10.8 0.0 1.3 1 0 0 1 1 1 0 NAD synthase Peptidase_M24 PF00557.19 EWC47192.1 - 5.3e-45 153.5 0.0 7e-45 153.1 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Casc1 PF12366.3 EWC47192.1 - 0.073 12.5 0.4 0.12 11.8 0.3 1.2 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 NST1 PF13945.1 EWC47192.1 - 0.081 12.9 0.3 0.13 12.3 0.2 1.3 1 0 0 1 1 1 0 Salt tolerance down-regulator PigN PF04987.9 EWC47193.1 - 1.5e-145 485.2 36.6 2.1e-145 484.7 25.3 1.2 1 0 0 1 1 1 1 Phosphatidylinositolglycan class N (PIG-N) Phosphodiest PF01663.17 EWC47193.1 - 6.9e-10 38.7 0.3 7.9e-09 35.2 0.2 2.1 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.18 EWC47193.1 - 1e-06 28.2 0.1 1.6e-06 27.5 0.1 1.3 1 0 0 1 1 1 1 Sulfatase Metalloenzyme PF01676.13 EWC47193.1 - 0.00053 19.4 0.1 0.00094 18.6 0.0 1.3 1 0 0 1 1 1 1 Metalloenzyme superfamily SWIRM PF04433.12 EWC47195.1 - 2.5e-15 56.3 0.0 8e-15 54.7 0.0 1.9 2 0 0 2 2 2 1 SWIRM domain Myb_DNA-binding PF00249.26 EWC47195.1 - 0.0012 18.7 0.0 0.0049 16.8 0.0 2.1 2 0 0 2 2 2 1 Myb-like DNA-binding domain zf-RING_2 PF13639.1 EWC47196.1 - 1.5e-07 31.1 4.0 2.4e-07 30.4 2.8 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.1 EWC47196.1 - 0.00022 20.8 1.1 0.00035 20.2 0.7 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.2 EWC47196.1 - 0.00068 19.7 0.5 0.0012 18.9 0.3 1.3 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 EWC47196.1 - 0.012 15.5 3.3 0.02 14.8 2.3 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EWC47196.1 - 0.042 13.5 3.2 0.067 12.8 2.2 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Fungal_trans_2 PF11951.3 EWC47197.1 - 4.6e-12 45.2 3.3 7.1e-12 44.6 2.3 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EWC47197.1 - 7e-08 32.2 7.6 1.4e-07 31.2 5.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2418 PF10332.4 EWC47197.1 - 0.65 10.3 4.3 0.75 10.1 0.1 3.0 4 0 0 4 4 4 0 Protein of unknown function (DUF2418) adh_short PF00106.20 EWC47198.1 - 2.1e-62 209.9 7.2 3.3e-31 108.4 0.7 2.3 2 0 0 2 2 2 2 short chain dehydrogenase KR PF08659.5 EWC47198.1 - 1.4e-30 106.3 1.7 2.6e-14 53.3 0.0 2.4 2 0 0 2 2 2 2 KR domain MaoC_dehydratas PF01575.14 EWC47198.1 - 1.2e-29 102.1 0.0 2.4e-29 101.1 0.0 1.5 1 0 0 1 1 1 1 MaoC like domain THF_DHG_CYH_C PF02882.14 EWC47198.1 - 0.0012 17.9 2.4 0.0026 16.8 0.4 2.2 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Epimerase PF01370.16 EWC47198.1 - 0.0019 17.6 4.3 0.023 14.1 0.1 2.8 3 1 0 3 3 3 1 NAD dependent epimerase/dehydratase family DUF4161 PF13722.1 EWC47198.1 - 0.037 14.3 0.4 1.5 9.1 0.1 2.3 2 0 0 2 2 2 0 C-terminal domain on CstA (DUF4161) ELFV_dehydrog PF00208.16 EWC47198.1 - 0.2 11.2 3.9 2.8 7.4 0.2 2.5 2 0 0 2 2 2 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 3Beta_HSD PF01073.14 EWC47198.1 - 0.25 9.9 5.5 0.021 13.5 0.3 1.8 2 1 0 2 2 2 0 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.1 EWC47198.1 - 8.8 6.2 8.1 25 4.8 0.1 3.1 2 1 0 2 2 2 0 NADH(P)-binding PAS_3 PF08447.6 EWC47199.1 - 8.3e-17 61.0 0.0 1.8e-09 37.5 0.0 2.3 2 0 0 2 2 2 2 PAS fold PAS PF00989.19 EWC47199.1 - 6.1e-12 45.3 0.0 0.00013 21.7 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.1 EWC47199.1 - 1.8e-11 44.3 0.0 1.8e-05 25.0 0.0 2.5 2 0 0 2 2 2 2 PAS domain PAS_11 PF14598.1 EWC47199.1 - 3.2e-10 39.9 0.0 2.7e-06 27.2 0.0 2.5 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.5 EWC47199.1 - 3.4e-09 36.7 0.0 0.00079 19.4 0.0 2.5 2 0 0 2 2 2 2 PAS fold Mit_ribos_Mrp51 PF11709.3 EWC47201.1 - 2e-45 155.3 0.6 6.2e-45 153.7 0.4 1.7 1 1 0 1 1 1 1 Mitochondrial ribosomal protein subunit Pkinase PF00069.20 EWC47202.1 - 6.9e-71 238.4 0.0 8.6e-71 238.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC47202.1 - 2.6e-33 115.1 0.0 3.6e-33 114.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.19 EWC47202.1 - 0.00063 20.2 0.0 0.0027 18.1 0.0 2.2 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.1 EWC47202.1 - 0.00075 18.5 0.0 0.0012 17.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like CUE PF02845.11 EWC47203.1 - 0.0046 16.4 0.0 0.051 13.0 0.0 2.7 3 0 0 3 3 3 1 CUE domain MannoseP_isomer PF01050.13 EWC47203.1 - 0.13 11.8 0.1 0.77 9.3 0.0 2.2 2 0 0 2 2 2 0 Mannose-6-phosphate isomerase Csm1 PF12539.3 EWC47204.1 - 1.8e-14 53.9 0.0 3.1e-14 53.2 0.0 1.4 1 0 0 1 1 1 1 Chromosome segregation protein Csm1/Pcs1 GAS PF13851.1 EWC47204.1 - 0.0099 15.0 8.7 0.017 14.3 6.1 1.3 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding CENP-F_leu_zip PF10473.4 EWC47204.1 - 0.037 13.8 9.6 0.07 12.9 0.9 2.2 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 APG6 PF04111.7 EWC47204.1 - 0.13 11.2 6.7 0.21 10.6 4.7 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 Spc7 PF08317.6 EWC47204.1 - 0.19 10.3 10.0 0.28 9.8 6.9 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Fib_alpha PF08702.5 EWC47204.1 - 0.44 10.6 6.0 0.76 9.8 4.2 1.3 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family HAUS6_N PF14661.1 EWC47204.1 - 0.84 8.9 9.0 1.4 8.2 6.2 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus Viral_P18 PF04521.8 EWC47204.1 - 1.8 8.0 7.8 3 7.3 2.0 2.3 2 0 0 2 2 2 0 ssRNA positive strand viral 18kD cysteine rich protein Mnd1 PF03962.10 EWC47204.1 - 1.9 8.0 12.4 17 4.9 8.6 2.1 1 1 0 1 1 1 0 Mnd1 family GrpE PF01025.14 EWC47204.1 - 2.1 7.8 11.5 30 4.0 8.0 2.2 1 1 0 1 1 1 0 GrpE TMF_DNA_bd PF12329.3 EWC47204.1 - 2.4 8.0 13.0 13 5.7 7.5 2.6 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding YlqD PF11068.3 EWC47204.1 - 3.1 7.8 9.4 3.6 7.6 5.6 1.7 1 1 0 1 1 1 0 YlqD protein DivIC PF04977.10 EWC47204.1 - 8.3 5.9 15.4 3 7.3 3.3 3.2 1 1 2 3 3 3 0 Septum formation initiator zf-H2C2_2 PF13465.1 EWC47205.1 - 2.4e-08 33.8 16.7 1.2e-05 25.3 1.9 3.5 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2 PF00096.21 EWC47205.1 - 2.1e-07 30.8 16.6 0.0014 18.8 0.9 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EWC47205.1 - 0.00068 19.7 15.8 0.059 13.7 0.8 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger DUF4551 PF15087.1 EWC47205.1 - 1.1 7.5 6.7 1.5 7.1 4.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) RecA PF00154.16 EWC47206.1 - 1.1e-10 41.1 0.1 2.7e-10 39.8 0.1 1.6 1 0 0 1 1 1 1 recA bacterial DNA recombination protein Rad51 PF08423.6 EWC47206.1 - 1.1e-05 24.4 0.1 0.00037 19.4 0.1 2.2 1 1 0 1 1 1 1 Rad51 KaiC PF06745.8 EWC47206.1 - 1.3e-05 24.4 0.1 2.4e-05 23.5 0.1 1.6 1 1 0 1 1 1 1 KaiC IstB_IS21 PF01695.12 EWC47206.1 - 3e-05 23.5 0.1 5.1e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein DnaB_C PF03796.10 EWC47206.1 - 0.00018 20.5 0.4 0.0017 17.3 0.0 2.0 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain AAA_25 PF13481.1 EWC47206.1 - 0.00042 19.7 0.7 0.001 18.5 0.1 1.9 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 EWC47206.1 - 0.00053 19.6 1.1 0.0016 18.1 0.0 2.4 3 0 0 3 3 3 1 Part of AAA domain AAA_22 PF13401.1 EWC47206.1 - 0.00053 20.1 0.0 0.0011 19.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.5 EWC47206.1 - 0.0019 17.4 0.0 0.0031 16.7 0.0 1.3 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_10 PF12846.2 EWC47206.1 - 0.0031 17.0 0.0 0.0054 16.2 0.0 1.4 1 0 0 1 1 1 1 AAA-like domain AAA PF00004.24 EWC47206.1 - 0.004 17.3 0.0 0.0091 16.2 0.0 1.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Arch_ATPase PF01637.13 EWC47206.1 - 0.0083 15.8 0.0 0.016 14.9 0.0 1.4 1 0 0 1 1 1 1 Archaeal ATPase ABC_tran PF00005.22 EWC47206.1 - 0.014 15.7 0.0 0.045 14.0 0.0 1.9 2 1 0 2 2 1 0 ABC transporter AAA_16 PF13191.1 EWC47206.1 - 0.016 15.1 0.4 0.046 13.7 0.3 1.8 1 1 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.1 EWC47206.1 - 0.024 14.4 0.0 0.058 13.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain Zot PF05707.7 EWC47206.1 - 0.039 13.4 0.0 0.073 12.5 0.0 1.4 1 0 0 1 1 1 0 Zonular occludens toxin (Zot) AAA_17 PF13207.1 EWC47206.1 - 0.049 14.4 0.0 0.096 13.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.4 EWC47206.1 - 0.051 12.5 0.0 0.066 12.1 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) TIP49 PF06068.8 EWC47206.1 - 0.098 11.3 0.1 0.17 10.5 0.0 1.3 1 0 0 1 1 1 0 TIP49 C-terminus Rad17 PF03215.10 EWC47206.1 - 0.12 11.0 0.0 0.18 10.4 0.0 1.2 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein DEAD PF00270.24 EWC47206.1 - 0.14 11.6 0.0 0.34 10.3 0.0 1.7 1 1 0 1 1 1 0 DEAD/DEAH box helicase Zeta_toxin PF06414.7 EWC47206.1 - 0.15 11.1 0.1 0.32 10.0 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin Xpo1 PF08389.7 EWC47207.1 - 1.2e-19 70.7 4.1 3.7e-19 69.0 0.4 3.3 3 0 0 3 3 3 1 Exportin 1-like protein IBN_N PF03810.14 EWC47207.1 - 2e-06 27.5 0.1 6.7e-05 22.7 0.0 2.8 2 1 0 2 2 2 1 Importin-beta N-terminal domain HEAT_2 PF13646.1 EWC47207.1 - 0.0015 18.7 0.1 0.021 15.1 0.0 2.9 2 0 0 2 2 2 1 HEAT repeats HEAT PF02985.17 EWC47207.1 - 0.0085 16.0 0.4 14 6.0 0.0 4.1 3 0 0 3 3 3 2 HEAT repeat HEAT_EZ PF13513.1 EWC47207.1 - 0.024 15.1 2.1 1.6 9.3 0.0 4.8 7 0 0 7 7 7 0 HEAT-like repeat 5-FTHF_cyc-lig PF01812.15 EWC47208.1 - 1.8e-41 141.9 0.0 2.1e-41 141.7 0.0 1.0 1 0 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family HAUS6_N PF14661.1 EWC47209.1 - 1.1e-37 129.7 2.4 1.7e-37 129.1 1.7 1.4 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 6 N-terminus HD_3 PF13023.1 EWC47210.1 - 1.1e-29 103.3 0.1 1.2e-29 103.1 0.1 1.0 1 0 0 1 1 1 1 HD domain HD PF01966.17 EWC47210.1 - 0.0001 22.2 0.0 0.00028 20.8 0.0 1.7 1 1 0 1 1 1 1 HD domain MFS_1 PF07690.11 EWC47211.1 - 4.7e-20 71.6 7.7 4.7e-20 71.6 5.3 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily E1_DerP2_DerF2 PF02221.10 EWC47212.1 - 5.8e-18 65.4 0.1 8.7e-18 64.8 0.0 1.3 1 1 0 1 1 1 1 ML domain TRP_N PF14558.1 EWC47212.1 - 0.0069 16.4 0.1 0.04 13.9 0.0 2.1 1 1 1 2 2 2 1 ML-like domain PHD PF00628.24 EWC47213.1 - 6.2e-09 35.4 8.8 1.2e-08 34.5 6.1 1.5 1 0 0 1 1 1 1 PHD-finger SET PF00856.23 EWC47213.1 - 5.7e-07 29.9 5.6 2.4e-06 27.9 0.0 3.8 3 2 1 4 4 4 1 SET domain PHD_2 PF13831.1 EWC47213.1 - 0.39 10.0 4.1 0.75 9.1 2.9 1.4 1 0 0 1 1 1 0 PHD-finger AUX_IAA PF02309.11 EWC47213.1 - 1.8 8.2 11.4 0.69 9.6 0.4 2.6 2 0 0 2 2 2 0 AUX/IAA family zf-CW PF07496.10 EWC47213.1 - 2.9 7.6 8.3 0.073 12.7 1.0 1.9 2 0 0 2 2 2 0 CW-type Zinc Finger AMP-binding PF00501.23 EWC47214.1 - 4.3e-88 295.4 0.1 6.7e-88 294.8 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 EWC47214.1 - 0.024 15.5 0.0 0.062 14.2 0.0 1.7 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain Methyltransf_16 PF10294.4 EWC47215.1 - 3.9e-17 62.2 0.0 1.2e-08 34.6 0.0 2.1 2 0 0 2 2 2 2 Putative methyltransferase CoA_transf_3 PF02515.12 EWC47216.1 - 7.4e-60 201.4 0.3 1.1e-59 200.9 0.2 1.2 1 0 0 1 1 1 1 CoA-transferase family III zf-AN1 PF01428.11 EWC47219.1 - 1.2e-23 82.6 16.2 2.8e-12 46.3 3.8 2.2 2 0 0 2 2 2 2 AN1-like Zinc finger IBR PF01485.16 EWC47219.1 - 0.00014 21.6 10.2 0.0005 19.8 0.8 2.4 2 0 0 2 2 2 2 IBR domain Transp_Tc5_C PF04236.10 EWC47219.1 - 0.034 14.3 10.9 0.13 12.5 2.5 2.4 2 0 0 2 2 2 0 Tc5 transposase C-terminal domain C1_4 PF07975.7 EWC47219.1 - 7.2 6.7 13.6 12 5.9 1.0 2.6 2 0 0 2 2 2 0 TFIIH C1-like domain Cys_Met_Meta_PP PF01053.15 EWC47220.1 - 3.7e-137 456.7 0.0 4.4e-137 456.4 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.12 EWC47220.1 - 3.2e-05 23.1 0.0 5.3e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.14 EWC47220.1 - 0.00012 20.9 0.0 0.00021 20.1 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.16 EWC47220.1 - 0.00019 20.5 0.0 0.0003 19.8 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II FAM101 PF15068.1 EWC47220.1 - 0.096 12.1 0.3 0.2 11.0 0.2 1.5 1 0 0 1 1 1 0 FAM101 family Beta_elim_lyase PF01212.16 EWC47220.1 - 0.11 11.6 0.0 0.21 10.7 0.0 1.4 1 0 0 1 1 1 0 Beta-eliminating lyase Kinesin PF00225.18 EWC47222.1 - 8.9e-64 215.3 0.0 1.4e-63 214.6 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain UL97 PF06734.7 EWC47222.1 - 0.11 11.8 0.0 0.54 9.5 0.0 2.0 2 0 0 2 2 2 0 UL97 DivIC PF04977.10 EWC47222.1 - 0.49 9.9 4.9 10 5.7 0.1 2.6 2 0 0 2 2 2 0 Septum formation initiator AAA_13 PF13166.1 EWC47222.1 - 2.5 6.4 9.7 3.5 5.9 6.7 1.1 1 0 0 1 1 1 0 AAA domain WD40 PF00400.27 EWC47223.1 - 1.9e-26 90.8 3.6 1.4e-07 31.1 0.0 5.9 5 1 0 5 5 5 4 WD domain, G-beta repeat Aconitase PF00330.15 EWC47225.1 - 3.1e-170 566.6 0.0 4.2e-170 566.2 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.14 EWC47225.1 - 9.6e-46 155.1 0.0 2.8e-45 153.6 0.0 1.9 2 0 0 2 2 2 1 Aconitase C-terminal domain Zip PF02535.17 EWC47225.1 - 0.22 10.4 8.5 0.34 9.8 5.9 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter NDT80_PhoG PF05224.7 EWC47226.1 - 8.8e-39 133.4 0.0 1.4e-38 132.7 0.0 1.3 1 0 0 1 1 1 1 NDT80 / PhoG like DNA-binding family Pterin_bind PF00809.17 EWC47229.1 - 1.4e-65 220.6 0.0 2.6e-65 219.7 0.0 1.5 1 0 0 1 1 1 1 Pterin binding enzyme HPPK PF01288.15 EWC47229.1 - 4.3e-40 136.3 0.0 1.3e-39 134.8 0.0 1.9 1 0 0 1 1 1 1 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) FolB PF02152.13 EWC47229.1 - 1.1e-31 109.3 0.3 1.6e-20 73.3 0.0 3.7 2 1 1 3 3 3 3 Dihydroneopterin aldolase eIF3g PF12353.3 EWC47230.1 - 4.1e-45 152.8 0.9 6.1e-45 152.2 0.6 1.3 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G RRM_1 PF00076.17 EWC47230.1 - 1e-17 63.4 0.0 1.7e-17 62.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EWC47230.1 - 5.8e-14 51.8 0.1 1.1e-13 50.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EWC47230.1 - 7.8e-06 25.6 0.3 2e-05 24.3 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 EWC47230.1 - 0.12 12.1 0.0 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif NMO PF03060.10 EWC47231.1 - 5.4e-71 239.4 0.8 6.5e-71 239.1 0.5 1.1 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.20 EWC47231.1 - 3.5e-08 32.7 1.1 1e-07 31.2 0.3 2.0 2 1 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.13 EWC47231.1 - 4e-05 22.6 2.3 6.6e-05 21.9 1.6 1.3 1 0 0 1 1 1 1 FMN-dependent dehydrogenase DHO_dh PF01180.16 EWC47231.1 - 0.022 13.7 0.4 0.036 13.0 0.3 1.3 1 0 0 1 1 1 0 Dihydroorotate dehydrogenase Glu_synthase PF01645.12 EWC47231.1 - 0.028 13.3 2.0 0.063 12.1 1.4 1.6 1 0 0 1 1 1 0 Conserved region in glutamate synthase ArfGap PF01412.13 EWC47232.1 - 2e-35 121.0 0.0 4.5e-35 119.9 0.0 1.5 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf UPF0128 PF03673.8 EWC47232.1 - 0.12 11.6 0.1 0.25 10.5 0.1 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0128) Syntaxin-18_N PF10496.4 EWC47233.1 - 7.3e-13 48.1 2.0 1.7e-12 47.0 0.1 2.6 2 1 1 3 3 3 1 SNARE-complex protein Syntaxin-18 N-terminus SUKH-4 PF14435.1 EWC47233.1 - 0.062 13.0 1.0 0.43 10.2 0.0 2.5 2 1 0 2 2 2 0 SUKH-4 immunity protein PsbW PF07123.7 EWC47233.1 - 0.84 9.6 5.1 0.38 10.8 1.4 1.9 2 0 0 2 2 2 0 Photosystem II reaction centre W protein (PsbW) Casc1 PF12366.3 EWC47233.1 - 7.8 5.9 8.6 0.87 9.0 1.9 2.0 2 0 0 2 2 2 0 Cancer susceptibility candidate 1 Glyco_hydro_47 PF01532.15 EWC47234.1 - 1.6e-124 415.9 0.1 1.9e-124 415.7 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 SH3_1 PF00018.23 EWC47235.1 - 2.6e-20 71.5 0.0 8e-11 41.1 0.0 2.5 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.1 EWC47235.1 - 4.1e-13 48.6 0.0 7.7e-06 25.3 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain PX PF00787.19 EWC47235.1 - 5.7e-13 48.6 0.0 1.8e-12 47.0 0.0 1.8 2 0 0 2 2 2 1 PX domain SH3_2 PF07653.12 EWC47235.1 - 4.9e-11 41.9 0.0 8.3e-08 31.6 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain PB1 PF00564.19 EWC47235.1 - 3.8e-06 26.4 0.3 7.9e-06 25.4 0.2 1.6 1 0 0 1 1 1 1 PB1 domain TPR_11 PF13414.1 EWC47236.1 - 0.0012 18.4 3.3 7.1 6.3 0.0 4.2 4 0 0 4 4 4 3 TPR repeat ChAPs PF09295.5 EWC47237.1 - 5e-156 519.4 0.0 7.7e-156 518.8 0.0 1.3 1 0 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_11 PF13414.1 EWC47237.1 - 8.7e-05 22.1 5.5 0.0087 15.6 0.2 3.3 3 1 1 4 4 4 2 TPR repeat TPR_19 PF14559.1 EWC47237.1 - 0.00026 21.2 0.2 2.1 8.7 0.0 3.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.1 EWC47237.1 - 0.00055 19.5 1.0 2.8 7.9 0.2 3.8 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 EWC47237.1 - 0.0027 17.6 2.7 0.062 13.2 0.2 3.1 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.23 EWC47237.1 - 0.0036 16.8 1.2 4.1 7.1 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.12 EWC47237.1 - 0.0052 16.6 2.1 8.8 6.5 0.0 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.1 EWC47237.1 - 0.0071 16.8 4.9 11 6.9 0.0 5.3 4 1 3 7 7 6 1 Tetratricopeptide repeat TPR_16 PF13432.1 EWC47237.1 - 0.021 15.5 0.4 12 6.6 0.0 3.4 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_15 PF13429.1 EWC47237.1 - 0.052 12.5 1.3 1.2 8.1 0.0 2.9 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.1 EWC47237.1 - 0.11 12.7 0.1 0.53 10.6 0.0 2.3 1 0 0 1 1 1 0 Tetratricopeptide repeat HSP70 PF00012.15 EWC47238.1 - 2.8e-262 871.0 12.2 3.3e-262 870.8 8.5 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 EWC47238.1 - 5.8e-12 44.8 2.2 1.2e-10 40.4 0.6 2.6 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.11 EWC47238.1 - 0.014 15.0 0.5 0.033 13.7 0.1 1.8 2 0 0 2 2 2 0 FGGY family of carbohydrate kinases, C-terminal domain Vps52 PF04129.7 EWC47238.1 - 0.12 10.8 0.3 0.19 10.2 0.2 1.2 1 0 0 1 1 1 0 Vps52 / Sac2 family TSC22 PF01166.13 EWC47238.1 - 0.15 12.0 1.1 0.55 10.2 0.8 1.9 1 1 0 1 1 1 0 TSC-22/dip/bun family FtsA PF14450.1 EWC47238.1 - 1.1 9.0 14.1 8.5 6.2 0.2 5.2 3 3 0 3 3 3 0 Cell division protein FtsA Hydantoinase_A PF01968.13 EWC47238.1 - 1.2 8.2 6.7 2 7.4 0.1 3.5 3 1 1 4 4 4 0 Hydantoinase/oxoprolinase DUF2415 PF10313.4 EWC47239.1 - 1.7e-13 49.9 0.1 1.4e-12 47.0 0.0 2.2 2 0 0 2 2 2 1 Uncharacterised protein domain (DUF2415) WD40 PF00400.27 EWC47239.1 - 1.9e-05 24.3 5.1 0.07 13.0 0.2 5.4 5 0 0 5 5 5 2 WD domain, G-beta repeat DUF566 PF04484.7 EWC47239.1 - 2.1 7.8 11.4 2.5 7.5 7.0 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF566) SAC3_GANP PF03399.11 EWC47240.1 - 4.3e-67 225.6 0.0 6.5e-67 225.0 0.0 1.3 1 0 0 1 1 1 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family Pkinase PF00069.20 EWC47241.1 - 1.8e-69 233.7 0.0 2.4e-69 233.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC47241.1 - 7.9e-30 103.7 0.0 1.1e-29 103.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.19 EWC47241.1 - 3.1e-12 46.8 1.0 3.1e-12 46.8 0.7 3.5 4 1 0 4 4 4 1 Protein kinase C terminal domain Kinase-like PF14531.1 EWC47241.1 - 1.4e-08 34.1 0.0 3.1e-08 32.9 0.0 1.6 2 0 0 2 2 2 1 Kinase-like C2 PF00168.25 EWC47241.1 - 0.00039 20.2 0.0 0.0012 18.6 0.0 1.9 1 1 0 1 1 1 1 C2 domain Kdo PF06293.9 EWC47241.1 - 0.025 13.6 0.0 0.04 12.9 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 EWC47241.1 - 0.045 13.4 0.0 0.083 12.6 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Glyco_transf_8 PF01501.15 EWC47245.1 - 4.6e-09 35.9 0.0 1e-08 34.8 0.0 1.5 1 1 0 1 1 1 1 Glycosyl transferase family 8 Mannosyl_trans3 PF11051.3 EWC47245.1 - 0.04 13.2 0.0 0.085 12.1 0.0 1.5 1 0 0 1 1 1 0 Mannosyltransferase putative Per1 PF04080.8 EWC47246.1 - 4.1e-82 275.6 11.8 5.6e-42 144.0 0.0 2.0 1 1 1 2 2 2 2 Per1-like CitMHS PF03600.11 EWC47246.1 - 0.0035 15.9 1.2 0.0063 15.1 0.9 1.3 1 0 0 1 1 1 1 Citrate transporter PGM_PMM_I PF02878.11 EWC47247.1 - 7.6e-17 61.0 0.0 1e-06 28.3 0.0 3.3 3 0 0 3 3 3 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.11 EWC47247.1 - 3.4e-13 49.8 0.1 2.7e-12 46.9 0.0 2.5 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.11 EWC47247.1 - 5.7e-06 26.3 0.0 1.1e-05 25.3 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III ApbA PF02558.11 EWC47248.1 - 2.7e-32 111.2 0.0 4.2e-32 110.6 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ApbA_C PF08546.6 EWC47248.1 - 2.1e-27 95.6 0.1 1.1e-25 89.9 0.0 2.2 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA C terminal DAO PF01266.19 EWC47248.1 - 0.0044 15.9 1.0 0.13 11.1 0.0 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_7 PF13241.1 EWC47248.1 - 0.017 15.3 0.0 0.034 14.3 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding FAD_binding_3 PF01494.14 EWC47248.1 - 0.02 13.9 0.0 0.033 13.2 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain NAD_binding_10 PF13460.1 EWC47248.1 - 0.063 13.2 0.0 0.13 12.2 0.0 1.6 1 1 0 1 1 1 0 NADH(P)-binding THDPS_N PF14790.1 EWC47248.1 - 0.11 12.1 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 Tetrahydrodipicolinate N-succinyltransferase N-terminal Pyr_redox PF00070.22 EWC47248.1 - 0.14 12.6 0.3 0.34 11.3 0.2 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DEAD PF00270.24 EWC47251.1 - 6.2e-18 64.8 0.0 1.3e-17 63.7 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EWC47251.1 - 2.5e-07 30.4 0.1 7.2e-07 28.9 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EWC47251.1 - 3.3e-07 30.3 0.2 1.9e-06 27.8 0.0 2.4 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit PhoH PF02562.11 EWC47251.1 - 0.026 13.7 0.0 0.051 12.7 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein Cyclin PF08613.6 EWC47252.1 - 3.8e-13 50.1 0.0 5.2e-13 49.6 0.0 1.3 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.18 EWC47252.1 - 9.9e-05 21.9 0.0 0.00028 20.4 0.0 1.7 2 0 0 2 2 2 1 Cyclin, N-terminal domain GMC_oxred_N PF00732.14 EWC47253.1 - 1.1e-53 182.3 0.0 1.4e-53 182.0 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.8 EWC47253.1 - 4.9e-39 133.9 0.1 7.5e-39 133.2 0.1 1.3 1 0 0 1 1 1 1 GMC oxidoreductase DAO PF01266.19 EWC47253.1 - 7.1e-06 25.1 0.0 0.056 12.3 0.0 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase Lycopene_cycl PF05834.7 EWC47253.1 - 0.00013 21.0 0.0 0.00021 20.3 0.0 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.1 EWC47253.1 - 0.00043 20.2 0.0 0.001 19.0 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 EWC47253.1 - 0.00097 19.2 0.1 0.063 13.3 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 EWC47253.1 - 0.0053 16.6 0.0 0.013 15.3 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 EWC47253.1 - 0.0092 14.8 1.6 0.37 9.5 0.1 2.4 2 0 0 2 2 2 1 Glucose inhibited division protein A FAD_binding_2 PF00890.19 EWC47253.1 - 0.014 14.2 0.2 0.092 11.5 0.0 2.0 2 0 0 2 2 2 0 FAD binding domain Thi4 PF01946.12 EWC47253.1 - 0.044 12.8 0.0 0.17 10.9 0.0 1.8 2 0 0 2 2 2 0 Thi4 family NAD_binding_9 PF13454.1 EWC47253.1 - 0.13 11.9 0.5 4.6 6.9 0.0 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding CRC_subunit PF08624.5 EWC47254.1 - 1.1e-56 190.6 0.1 1.8e-56 189.9 0.1 1.4 1 0 0 1 1 1 1 Chromatin remodelling complex Rsc7/Swp82 subunit TFIIB PF00382.14 EWC47255.1 - 1.6e-35 120.7 1.0 1.4e-18 66.4 0.1 2.5 2 0 0 2 2 2 2 Transcription factor TFIIB repeat BRF1 PF07741.8 EWC47255.1 - 5.6e-27 93.8 2.2 5.6e-27 93.8 1.5 2.4 2 0 0 2 2 2 1 Brf1-like TBP-binding domain Cyclin_N PF00134.18 EWC47255.1 - 7.9e-07 28.6 0.6 0.002 17.7 0.1 2.3 2 0 0 2 2 2 2 Cyclin, N-terminal domain TF_Zn_Ribbon PF08271.7 EWC47255.1 - 0.0026 17.0 4.1 0.0066 15.7 2.9 1.7 1 0 0 1 1 1 1 TFIIB zinc-binding Peptidase_M90 PF06167.7 EWC47256.1 - 0.028 13.8 0.5 0.25 10.7 0.0 2.1 1 1 1 2 2 2 0 Glucose-regulated metallo-peptidase M90 F-box-like PF12937.2 EWC47257.1 - 1.8e-05 24.3 7.4 0.0034 17.0 0.3 2.8 3 0 0 3 3 3 2 F-box-like F-box PF00646.28 EWC47257.1 - 0.00014 21.4 0.5 0.086 12.5 0.0 2.5 2 0 0 2 2 2 2 F-box domain DUF3294 PF07957.6 EWC47259.1 - 1.4e-05 24.7 0.1 3.5e-05 23.4 0.0 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF3294) Fez1 PF06818.10 EWC47259.1 - 3.1e-05 24.0 0.3 3.8e-05 23.8 0.2 1.2 1 0 0 1 1 1 1 Fez1 Lzipper-MIP1 PF14389.1 EWC47259.1 - 0.013 15.5 0.2 0.024 14.7 0.2 1.4 1 0 0 1 1 1 0 Leucine-zipper of ternary complex factor MIP1 CENP-Q PF13094.1 EWC47259.1 - 0.053 13.5 3.1 0.085 12.8 0.5 2.0 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Cast PF10174.4 EWC47259.1 - 0.057 11.4 0.5 0.076 11.0 0.3 1.1 1 0 0 1 1 1 0 RIM-binding protein of the cytomatrix active zone Glyco_hydro_7 PF00840.15 EWC47260.1 - 5.1e-212 703.9 19.4 6e-212 703.6 13.5 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 7 AAA PF00004.24 EWC47261.1 - 2.8e-40 137.5 0.0 5.7e-40 136.5 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 EWC47261.1 - 6.5e-05 22.6 0.1 0.00034 20.3 0.0 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 EWC47261.1 - 0.00018 21.5 0.2 0.018 15.0 0.0 2.6 1 1 1 2 2 2 1 AAA ATPase domain AAA_2 PF07724.9 EWC47261.1 - 0.00036 20.4 0.3 0.0022 17.9 0.0 2.4 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.7 EWC47261.1 - 0.00039 19.5 0.0 0.0008 18.5 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus PhoH PF02562.11 EWC47261.1 - 0.0024 17.1 0.1 0.029 13.5 0.1 2.2 2 0 0 2 2 2 1 PhoH-like protein AAA_22 PF13401.1 EWC47261.1 - 0.0036 17.4 2.9 0.023 14.8 0.0 2.6 2 1 1 3 3 2 1 AAA domain Mg_chelatase PF01078.16 EWC47261.1 - 0.0045 16.1 0.1 0.014 14.6 0.1 1.8 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI DUF815 PF05673.8 EWC47261.1 - 0.01 14.7 0.0 0.031 13.2 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_33 PF13671.1 EWC47261.1 - 0.012 15.5 0.0 0.028 14.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.1 EWC47261.1 - 0.015 15.0 0.3 0.043 13.5 0.2 1.8 1 0 0 1 1 1 0 Part of AAA domain IstB_IS21 PF01695.12 EWC47261.1 - 0.018 14.4 0.1 0.039 13.3 0.1 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_25 PF13481.1 EWC47261.1 - 0.033 13.6 1.6 0.5 9.7 0.1 2.4 1 1 1 2 2 2 0 AAA domain AAA_24 PF13479.1 EWC47261.1 - 0.059 12.9 0.1 0.14 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.1 EWC47261.1 - 0.063 13.1 0.0 0.19 11.6 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.1 EWC47261.1 - 0.066 14.0 0.1 0.24 12.2 0.1 2.0 1 1 0 1 1 1 0 AAA domain Sigma54_activat PF00158.21 EWC47261.1 - 0.097 12.1 0.0 0.32 10.4 0.0 1.9 2 0 0 2 2 2 0 Sigma-54 interaction domain RNA_helicase PF00910.17 EWC47261.1 - 0.16 12.1 0.0 0.85 9.8 0.0 2.2 2 0 0 2 2 2 0 RNA helicase ERCC4 PF02732.10 EWC47262.1 - 8.2e-23 80.7 0.0 1.4e-22 79.9 0.0 1.4 1 0 0 1 1 1 1 ERCC4 domain HHH_8 PF14716.1 EWC47262.1 - 6.6e-06 26.2 0.0 1.7e-05 24.8 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix domain Brix PF04427.13 EWC47263.1 - 1e-49 168.7 0.0 1.3e-49 168.4 0.0 1.1 1 0 0 1 1 1 1 Brix domain Nop25 PF09805.4 EWC47263.1 - 2.2 8.3 20.9 4.2 7.4 14.5 1.5 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) zf-C2H2_4 PF13894.1 EWC47264.1 - 0.35 11.2 16.3 2 8.9 0.3 5.2 5 0 0 5 5 5 0 C2H2-type zinc finger zf-C2H2 PF00096.21 EWC47264.1 - 2.4 8.7 19.7 1.6 9.2 0.2 4.8 4 1 0 4 4 4 0 Zinc finger, C2H2 type DEAD PF00270.24 EWC47265.1 - 2.8e-45 153.8 0.0 6.7e-45 152.6 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EWC47265.1 - 2.4e-25 88.2 0.0 5.8e-25 86.9 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EWC47265.1 - 0.046 13.5 0.1 1.9 8.3 0.0 3.1 3 1 0 3 3 3 0 Type III restriction enzyme, res subunit DUF305 PF03713.8 EWC47265.1 - 0.14 11.9 1.5 0.23 11.2 0.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF305) Peptidase_S24 PF00717.18 EWC47266.1 - 4.5e-10 39.0 0.0 2.4e-09 36.6 0.0 2.0 1 1 1 2 2 2 1 Peptidase S24-like RdRP_4 PF02123.11 EWC47267.1 - 0.22 10.2 3.1 0.32 9.6 2.2 1.1 1 0 0 1 1 1 0 Viral RNA-directed RNA-polymerase ARGLU PF15346.1 EWC47267.1 - 0.38 10.5 15.8 0.037 13.7 7.2 2.1 2 0 0 2 2 2 0 Arginine and glutamate-rich 1 Lum_binding PF00677.12 EWC47269.1 - 2.5e-36 123.4 2.5 2.8e-18 65.5 0.0 2.3 2 0 0 2 2 2 2 Lumazine binding domain BTB PF00651.26 EWC47270.1 - 6.2e-05 22.9 0.0 0.00045 20.1 0.0 2.1 2 0 0 2 2 2 1 BTB/POZ domain Aldo_ket_red PF00248.16 EWC47273.1 - 6.8e-44 149.7 0.0 7.8e-44 149.5 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Herpes_Helicase PF02689.9 EWC47273.1 - 0.12 10.0 0.0 0.14 9.8 0.0 1.1 1 0 0 1 1 1 0 Helicase Transthyretin PF00576.16 EWC47274.1 - 5.9e-30 103.4 0.0 7.3e-30 103.1 0.0 1.1 1 0 0 1 1 1 1 HIUase/Transthyretin family CarboxypepD_reg PF13620.1 EWC47274.1 - 0.14 12.2 0.3 0.32 11.0 0.2 1.7 1 1 0 1 1 1 0 Carboxypeptidase regulatory-like domain Zn_clus PF00172.13 EWC47275.1 - 8.6e-09 35.1 9.3 1.7e-08 34.2 6.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.3 EWC47275.1 - 0.00012 20.8 0.2 0.00026 19.7 0.1 1.4 1 1 0 1 1 1 1 Fungal specific transcription factor domain RabGAP-TBC PF00566.13 EWC47277.1 - 1.6e-34 119.2 0.1 8.8e-34 116.8 0.1 2.0 1 1 0 1 1 1 1 Rab-GTPase-TBC domain Pkinase PF00069.20 EWC47279.1 - 1.9e-67 227.1 0.0 2.5e-67 226.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC47279.1 - 3e-34 118.2 0.0 4.1e-34 117.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EWC47279.1 - 2.5e-05 23.3 0.0 6.9e-05 21.9 0.0 1.7 2 0 0 2 2 2 1 Kinase-like BCS1_N PF08740.6 EWC47281.1 - 4.9e-46 156.7 0.4 6.6e-46 156.2 0.3 1.2 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.24 EWC47281.1 - 3.7e-18 65.9 0.0 8.7e-18 64.7 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 EWC47281.1 - 3.6e-06 27.7 0.0 6.6e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 EWC47281.1 - 5e-05 23.1 0.0 0.00021 21.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 EWC47281.1 - 8.4e-05 22.6 0.0 0.00029 20.8 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain AAA_18 PF13238.1 EWC47281.1 - 0.00035 20.8 0.0 0.0015 18.8 0.0 2.0 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.8 EWC47281.1 - 0.0012 17.8 0.0 0.0019 17.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_22 PF13401.1 EWC47281.1 - 0.0014 18.7 0.0 0.0036 17.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.22 EWC47281.1 - 0.0041 17.4 0.0 0.0076 16.5 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_19 PF13245.1 EWC47281.1 - 0.0044 16.7 0.0 0.023 14.4 0.0 2.3 2 1 0 2 2 2 1 Part of AAA domain AAA_29 PF13555.1 EWC47281.1 - 0.0045 16.4 0.0 0.0094 15.4 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_5 PF07728.9 EWC47281.1 - 0.016 14.9 0.0 0.045 13.4 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_25 PF13481.1 EWC47281.1 - 0.019 14.3 0.0 0.061 12.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.7 EWC47281.1 - 0.024 13.7 0.0 0.047 12.7 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin RNA_helicase PF00910.17 EWC47281.1 - 0.033 14.3 0.0 0.07 13.3 0.0 1.6 1 0 0 1 1 1 0 RNA helicase Viral_helicase1 PF01443.13 EWC47281.1 - 0.044 13.2 0.1 0.23 10.9 0.0 2.1 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase KAP_NTPase PF07693.9 EWC47281.1 - 0.1 11.5 0.0 0.17 10.8 0.0 1.2 1 0 0 1 1 1 0 KAP family P-loop domain AAA_21 PF13304.1 EWC47281.1 - 0.13 12.1 0.1 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.1 EWC47281.1 - 0.15 11.6 0.1 4.7 6.7 0.0 2.4 3 0 0 3 3 3 0 AAA domain UQ_con PF00179.21 EWC47282.1 - 2.1e-42 143.8 0.0 2.3e-42 143.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 EWC47282.1 - 1.2e-05 25.0 0.0 1.5e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 EWC47282.1 - 0.061 13.2 0.0 0.069 13.0 0.0 1.3 1 0 0 1 1 1 0 RWD domain LRR_6 PF13516.1 EWC47283.1 - 2.3e-08 33.2 7.0 0.07 13.2 0.2 6.2 7 0 0 7 7 7 4 Leucine Rich repeat LRR_4 PF12799.2 EWC47283.1 - 8.8e-07 28.4 5.7 0.023 14.3 0.3 3.8 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 EWC47283.1 - 0.13 12.0 6.1 9.9 6.0 0.2 3.8 3 1 1 4 4 3 0 Leucine rich repeat LRR_7 PF13504.1 EWC47283.1 - 1.9 9.0 6.5 1.6e+02 3.2 0.0 4.8 5 0 0 5 5 5 0 Leucine rich repeat SUR7 PF06687.7 EWC47284.1 - 0.032 13.8 0.0 0.032 13.8 0.0 2.5 3 0 0 3 3 3 0 SUR7/PalI family Acyl_transf_3 PF01757.17 EWC47284.1 - 0.088 11.6 2.9 3.8 6.2 0.0 2.2 2 0 0 2 2 2 0 Acyltransferase family CD20 PF04103.10 EWC47284.1 - 0.27 11.1 6.3 1.1 9.2 0.7 3.0 3 1 0 3 3 3 0 CD20-like family Mucin PF01456.12 EWC47284.1 - 7.2 6.3 12.6 0.28 10.9 4.6 1.7 2 0 0 2 2 2 0 Mucin-like glycoprotein PPR_3 PF13812.1 EWC47285.1 - 0.0024 18.0 4.3 0.11 12.8 0.0 4.2 4 0 0 4 4 4 1 Pentatricopeptide repeat domain PPR_2 PF13041.1 EWC47285.1 - 0.041 13.8 0.0 0.63 10.0 0.0 3.0 4 0 0 4 4 4 0 PPR repeat family SKG6 PF08693.5 EWC47286.1 - 0.0011 18.1 1.0 0.002 17.4 0.7 1.4 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Herpes_gE PF02480.11 EWC47286.1 - 0.013 13.8 0.3 0.024 12.9 0.0 1.5 1 1 1 2 2 2 0 Alphaherpesvirus glycoprotein E EphA2_TM PF14575.1 EWC47286.1 - 0.093 13.1 0.0 0.17 12.2 0.0 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Syndecan PF01034.15 EWC47286.1 - 0.24 11.0 1.0 0.47 10.1 0.3 1.7 2 0 0 2 2 2 0 Syndecan domain TALPID3 PF15324.1 EWC47286.1 - 0.26 8.5 9.2 0.34 8.2 6.4 1.1 1 0 0 1 1 1 0 Hedgehog signalling target DUF3433 PF11915.3 EWC47287.1 - 4.9e-45 151.6 2.2 2.1e-25 88.6 0.2 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF3433) zf-PARP PF00645.13 EWC47288.1 - 1.9e-18 66.4 0.0 4.2e-18 65.3 0.0 1.6 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region GPI-anchored PF10342.4 EWC47289.1 - 1.7e-17 63.6 9.0 5.2e-17 62.1 0.0 2.5 2 1 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family ATS PF15445.1 EWC47289.1 - 1 8.3 3.4 2 7.4 2.4 1.4 1 1 0 1 1 1 0 acidic terminal segments, variant surface antigen of PfEMP1 Aldo_ket_red PF00248.16 EWC47290.1 - 1.9e-35 122.0 0.0 2.5e-34 118.3 0.0 2.1 1 1 0 1 1 1 1 Aldo/keto reductase family Pkinase PF00069.20 EWC47291.1 - 2.4e-23 82.6 0.0 4.1e-23 81.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC47291.1 - 1.2e-22 80.2 0.0 2.1e-22 79.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase TPR_12 PF13424.1 EWC47291.1 - 6.7e-13 48.3 15.1 2.1e-05 24.3 0.0 8.5 5 2 6 11 11 11 5 Tetratricopeptide repeat TPR_10 PF13374.1 EWC47291.1 - 1.7e-08 34.1 1.3 0.21 11.5 0.1 4.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.12 EWC47291.1 - 0.057 13.3 0.9 14 5.8 0.0 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat Pox_ser-thr_kin PF05445.6 EWC47291.1 - 0.12 11.1 0.0 0.2 10.4 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Rho_Binding PF08912.6 EWC47291.1 - 0.67 10.2 6.2 2.5 8.4 0.7 3.6 3 0 0 3 3 3 0 Rho Binding Pkinase PF00069.20 EWC47292.1 - 6.7e-35 120.4 0.0 5.4e-32 110.9 0.0 2.5 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 EWC47292.1 - 5e-23 81.4 0.0 2.2e-21 76.1 0.0 3.2 2 2 0 2 2 2 1 Protein tyrosine kinase oligo_HPY PF08352.7 EWC47293.1 - 0.046 14.0 0.7 0.19 12.1 0.1 2.2 2 0 0 2 2 2 0 Oligopeptide/dipeptide transporter, C-terminal region Shadoo PF14999.1 EWC47293.1 - 0.16 11.8 6.9 0.33 10.8 4.8 1.5 1 0 0 1 1 1 0 Shadow of prion protein, neuroprotective DUF2570 PF10828.3 EWC47293.1 - 3.4 7.3 6.6 0.18 11.4 0.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2570) DSPc PF00782.15 EWC47295.1 - 0.00032 20.2 0.0 0.00083 18.9 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Rhodanese PF00581.15 EWC47295.1 - 0.026 14.8 0.0 0.089 13.1 0.0 1.9 1 1 0 1 1 1 0 Rhodanese-like domain Y_phosphatase3 PF13350.1 EWC47295.1 - 0.099 12.8 1.4 0.13 12.5 0.0 1.9 2 1 0 2 2 2 0 Tyrosine phosphatase family Fungal_trans PF04082.13 EWC47298.1 - 1.1e-24 86.7 1.9 1.7e-24 86.1 1.4 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EWC47298.1 - 6.6e-08 32.3 6.8 1.3e-07 31.4 4.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FAD_binding_4 PF01565.18 EWC47300.1 - 1.4e-21 76.3 2.1 2.8e-21 75.4 1.5 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.7 EWC47300.1 - 0.061 13.2 0.1 1.1 9.2 0.0 2.5 2 0 0 2 2 2 0 Berberine and berberine like Sorting_nexin PF03700.8 EWC47300.1 - 0.25 11.4 0.0 0.43 10.6 0.0 1.3 1 0 0 1 1 1 0 Sorting nexin, N-terminal domain APH PF01636.18 EWC47301.1 - 5.9e-12 45.8 0.1 8.4e-12 45.3 0.1 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.15 EWC47301.1 - 4.5e-05 22.7 0.0 9.2e-05 21.7 0.0 1.5 1 0 0 1 1 1 1 Ecdysteroid kinase DUF1679 PF07914.6 EWC47301.1 - 0.001 17.7 0.0 0.0015 17.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) AA_permease_2 PF13520.1 EWC47303.1 - 2e-59 201.2 52.3 2.7e-59 200.8 36.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EWC47303.1 - 2.1e-24 85.7 46.3 2.8e-24 85.3 32.1 1.1 1 0 0 1 1 1 1 Amino acid permease Methyltransf_23 PF13489.1 EWC47305.1 - 1e-19 70.8 0.0 1.8e-19 70.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EWC47305.1 - 6.8e-09 36.0 0.0 2.8e-08 34.1 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 EWC47305.1 - 1.3e-08 34.5 0.0 9.9e-07 28.4 0.0 2.9 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 EWC47305.1 - 2.5e-08 34.2 0.0 1.6e-06 28.5 0.0 3.0 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 EWC47305.1 - 3.9e-06 27.4 0.0 7e-05 23.3 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EWC47305.1 - 0.00062 19.1 0.0 0.014 14.8 0.0 2.6 3 0 0 3 3 3 1 Methyltransferase small domain CMAS PF02353.15 EWC47305.1 - 0.0034 16.4 0.0 0.043 12.8 0.0 2.3 2 1 0 2 2 2 1 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.13 EWC47305.1 - 0.012 14.7 0.0 0.89 8.6 0.0 2.7 3 0 0 3 3 3 0 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.12 EWC47305.1 - 0.013 14.5 0.0 0.033 13.2 0.0 1.7 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_26 PF13659.1 EWC47305.1 - 0.014 15.3 0.0 0.11 12.5 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.1 EWC47305.1 - 0.015 15.6 0.0 0.047 14.0 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase domain PrmA PF06325.8 EWC47305.1 - 0.02 13.9 0.0 0.045 12.8 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) FtsJ PF01728.14 EWC47305.1 - 0.056 13.4 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 FtsJ-like methyltransferase Ribosomal_TL5_C PF14693.1 EWC47305.1 - 0.094 12.9 0.0 0.18 12.0 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein TL5, C-terminal domain Methyltransf_16 PF10294.4 EWC47305.1 - 0.11 11.9 0.0 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase PCMT PF01135.14 EWC47305.1 - 0.13 11.8 0.0 0.27 10.7 0.0 1.5 2 0 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Zn_clus PF00172.13 EWC47306.1 - 3e-07 30.2 8.8 5.5e-07 29.3 6.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 EWC47306.1 - 7.1e-05 21.8 0.7 0.00017 20.5 0.5 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain TPR_12 PF13424.1 EWC47306.1 - 0.04 13.8 0.0 0.073 13.0 0.0 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat Sugar_tr PF00083.19 EWC47307.1 - 5.5e-89 298.8 17.6 6.2e-89 298.6 12.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EWC47307.1 - 5e-40 137.3 41.3 6.9e-32 110.5 18.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 EWC47307.1 - 6.4e-10 37.9 19.3 1.4e-05 23.7 2.3 3.2 2 1 1 3 3 3 3 MFS/sugar transport protein MFS_1_like PF12832.2 EWC47307.1 - 3.1e-05 23.6 0.2 0.23 11.2 0.1 2.7 2 0 0 2 2 2 2 MFS_1 like family MFS_3 PF05977.8 EWC47307.1 - 0.0016 16.6 2.2 0.099 10.7 0.1 2.3 2 0 0 2 2 2 2 Transmembrane secretion effector TRI12 PF06609.8 EWC47307.1 - 0.026 12.7 12.0 0.29 9.2 2.4 2.3 1 1 1 2 2 2 0 Fungal trichothecene efflux pump (TRI12) AA_permease PF00324.16 EWC47308.1 - 2.5e-117 392.1 37.6 3e-117 391.9 26.1 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EWC47308.1 - 7.6e-33 113.6 40.3 1.1e-32 113.1 28.0 1.2 1 0 0 1 1 1 1 Amino acid permease MFS_1 PF07690.11 EWC47309.1 - 4.7e-39 134.0 43.4 4.6e-37 127.5 30.1 2.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EWC47309.1 - 6.8e-09 34.7 23.8 6e-08 31.7 7.0 2.5 2 1 0 2 2 2 2 Sugar (and other) transporter Sulfatase PF00884.18 EWC47310.1 - 5.7e-45 153.8 0.3 5.8e-44 150.5 0.0 2.1 1 1 1 2 2 2 1 Sulfatase Phosphodiest PF01663.17 EWC47310.1 - 0.032 13.5 0.0 0.055 12.7 0.0 1.3 1 0 0 1 1 1 0 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.12 EWC47310.1 - 0.11 10.8 0.0 0.18 10.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF229) DUF1501 PF07394.7 EWC47310.1 - 0.19 10.5 0.1 0.4 9.4 0.0 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1501) MFS_1 PF07690.11 EWC47312.1 - 3e-37 128.1 41.0 1.1e-36 126.3 27.7 2.2 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EWC47312.1 - 2.5e-13 49.4 24.8 3.7e-13 48.8 7.0 2.5 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_3 PF05977.8 EWC47312.1 - 2.6e-05 22.5 2.9 2.6e-05 22.5 2.0 2.4 1 1 0 2 2 2 1 Transmembrane secretion effector ACP_syn_III_C PF08541.5 EWC47312.1 - 0.83 9.7 3.9 0.75 9.8 0.1 2.6 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal Peptidase_M14 PF00246.19 EWC47313.1 - 6.9e-72 242.3 0.1 8.5e-72 242.0 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.11 EWC47313.1 - 4.5e-12 45.4 0.1 1.1e-11 44.1 0.1 1.7 1 0 0 1 1 1 1 Carboxypeptidase activation peptide p450 PF00067.17 EWC47314.1 - 1.5e-81 274.3 0.0 2.5e-81 273.5 0.0 1.3 1 0 0 1 1 1 1 Cytochrome P450 FAD_binding_1 PF00667.15 EWC47314.1 - 6.3e-30 104.2 0.0 2.3e-29 102.4 0.0 1.8 2 0 0 2 2 2 1 FAD binding domain Flavodoxin_1 PF00258.20 EWC47314.1 - 2.1e-23 82.8 0.0 3.9e-23 82.0 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.16 EWC47314.1 - 1.4e-13 51.3 0.0 9.6e-13 48.6 0.0 2.3 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Flavodoxin_5 PF12724.2 EWC47314.1 - 0.12 12.3 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 Flavodoxin domain FAD_binding_6 PF00970.19 EWC47314.1 - 0.14 12.2 0.0 0.78 9.9 0.0 2.1 2 0 0 2 2 2 0 Oxidoreductase FAD-binding domain Glyoxalase PF00903.20 EWC47316.1 - 1.7e-30 105.6 0.1 7e-17 61.5 0.0 2.2 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.2 EWC47316.1 - 1.2e-26 93.4 0.1 6.1e-15 55.7 0.0 2.3 2 0 0 2 2 2 2 Glyoxalase-like domain Glyoxalase_4 PF13669.1 EWC47316.1 - 4.2e-14 52.4 0.0 1.5e-08 34.6 0.0 3.2 2 2 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.1 EWC47316.1 - 0.0014 18.5 0.0 0.032 14.1 0.0 2.7 2 2 0 2 2 2 1 Glyoxalase-like domain Annexin PF00191.15 EWC47317.1 - 3.2e-49 164.6 2.0 7.3e-13 48.2 0.0 4.4 4 1 0 4 4 4 4 Annexin PAT1 PF09770.4 EWC47319.1 - 3.1 5.9 12.5 4.4 5.4 8.7 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Tim17 PF02466.14 EWC47320.1 - 1.8e-27 95.9 3.3 2.3e-27 95.5 2.3 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family DUF2428 PF10350.4 EWC47321.1 - 2.7e-55 187.1 0.0 6.4e-55 185.9 0.0 1.6 2 0 0 2 2 2 1 Putative death-receptor fusion protein (DUF2428) HEAT PF02985.17 EWC47321.1 - 0.083 13.0 0.1 63 4.0 0.0 4.3 4 0 0 4 4 4 0 HEAT repeat HEAT_EZ PF13513.1 EWC47322.1 - 0.0029 18.0 0.5 0.011 16.1 0.1 2.2 2 0 0 2 2 2 1 HEAT-like repeat HEAT PF02985.17 EWC47322.1 - 0.075 13.1 0.1 0.28 11.3 0.0 2.0 2 0 0 2 2 2 0 HEAT repeat Sedlin_N PF04628.8 EWC47324.1 - 2.3e-42 143.9 0.0 2.6e-42 143.8 0.0 1.0 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.7 EWC47324.1 - 7e-10 38.7 0.1 1e-09 38.2 0.1 1.3 1 1 0 1 1 1 1 Sybindin-like family COX7a PF02238.10 EWC47325.1 - 0.00037 20.1 0.0 0.00044 19.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIIa B12D PF06522.6 EWC47325.1 - 0.00051 19.6 0.7 0.056 13.1 0.0 2.1 2 0 0 2 2 2 2 NADH-ubiquinone reductase complex 1 MLRQ subunit DUF1682 PF07946.9 EWC47326.1 - 1.5e-85 286.8 0.6 1.8e-85 286.6 0.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) tRNA-synt_1d PF00750.14 EWC47327.1 - 2.6e-89 299.4 2.4 3.3e-89 299.1 1.7 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.10 EWC47327.1 - 1.1e-29 102.8 0.2 2.4e-29 101.6 0.1 1.7 1 0 0 1 1 1 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.11 EWC47327.1 - 0.00017 22.0 0.1 0.00067 20.1 0.0 2.1 2 0 0 2 2 2 1 Arginyl tRNA synthetase N terminal domain DUF77 PF01910.12 EWC47328.1 - 4.3e-15 55.1 0.0 5.6e-15 54.7 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function DUF77 CBM_1 PF00734.13 EWC47329.1 - 6.6e-14 51.2 7.5 1e-13 50.6 5.2 1.3 1 0 0 1 1 1 1 Fungal cellulose binding domain YARHG PF13308.1 EWC47330.1 - 0.022 14.2 0.0 0.057 12.9 0.0 1.7 1 0 0 1 1 1 0 YARHG domain EI24 PF07264.6 EWC47332.1 - 0.002 17.5 14.8 0.0051 16.2 10.2 1.7 1 1 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) Ion_trans_2 PF07885.11 EWC47333.1 - 1e-25 89.2 26.1 6.9e-15 54.5 3.6 3.0 3 0 0 3 3 3 2 Ion channel zf-primase PF09329.6 EWC47334.1 - 1.8e-18 65.8 1.2 3e-18 65.1 0.8 1.4 1 0 0 1 1 1 1 Primase zinc finger tRNA_anti-codon PF01336.20 EWC47334.1 - 0.0012 18.6 0.0 0.0026 17.5 0.0 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain RNase_T PF00929.19 EWC47335.1 - 3.3e-25 89.2 0.0 4.3e-25 88.8 0.0 1.2 1 0 0 1 1 1 1 Exonuclease Ribosomal_L9_N PF01281.14 EWC47336.1 - 4.9e-05 22.4 0.0 0.0001 21.4 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L9, N-terminal domain Ribosomal_L9_C PF03948.9 EWC47336.1 - 0.0012 18.8 3.4 0.004 17.2 0.5 2.7 2 1 0 2 2 2 1 Ribosomal protein L9, C-terminal domain F_bP_aldolase PF01116.15 EWC47337.1 - 3.3e-99 331.6 0.0 3.7e-99 331.4 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II Peptidase_C26 PF07722.8 EWC47337.1 - 0.078 12.4 0.0 2.4 7.5 0.0 2.2 2 0 0 2 2 2 0 Peptidase C26 DUF221 PF02714.10 EWC47338.1 - 4.4e-84 282.1 21.4 4.4e-84 282.1 14.8 2.1 2 0 0 2 2 2 1 Domain of unknown function DUF221 RSN1_TM PF13967.1 EWC47338.1 - 6.7e-34 116.7 1.4 6.7e-34 116.7 1.0 2.8 2 0 0 2 2 2 1 Late exocytosis, associated with Golgi transport DUF4463 PF14703.1 EWC47338.1 - 1e-14 54.7 0.2 2.8e-14 53.3 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4463) PGM_PMM_I PF02878.11 EWC47339.1 - 3.1e-30 104.4 0.0 4.8e-30 103.8 0.0 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.11 EWC47339.1 - 2.3e-23 82.3 0.0 3.9e-23 81.6 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.11 EWC47339.1 - 1.7e-12 47.6 0.0 3.5e-12 46.5 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.15 EWC47339.1 - 1.5e-07 31.2 0.0 3.5e-07 30.1 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Oxysterol_BP PF01237.13 EWC47340.1 - 1.3e-88 296.9 0.0 1.7e-88 296.4 0.0 1.1 1 0 0 1 1 1 1 Oxysterol-binding protein UCH PF00443.24 EWC47341.1 - 5.6e-37 127.3 0.1 2.1e-31 109.0 0.0 2.6 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 EWC47341.1 - 5.1e-12 45.8 0.0 8.5e-12 45.1 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Calici_coat PF00915.15 EWC47342.1 - 0.4 9.5 5.4 0.78 8.5 3.7 1.4 1 0 0 1 1 1 0 Calicivirus coat protein TTL PF03133.10 EWC47343.1 - 2.7e-48 164.4 0.0 3.9e-48 163.8 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family SurE PF01975.12 EWC47343.1 - 2.3e-42 144.5 0.0 3.5e-42 143.9 0.0 1.2 1 0 0 1 1 1 1 Survival protein SurE ATP-grasp_4 PF13535.1 EWC47343.1 - 0.00028 20.6 0.1 0.0037 17.0 0.0 2.4 2 0 0 2 2 2 1 ATP-grasp domain Glyco_transf_28 PF03033.15 EWC47343.1 - 0.011 15.4 0.0 3.8 7.2 0.0 2.8 3 0 0 3 3 3 0 Glycosyltransferase family 28 N-terminal domain PAP1 PF08601.5 EWC47344.1 - 0.41 10.2 4.5 0.51 9.9 3.1 1.0 1 0 0 1 1 1 0 Transcription factor PAP1 Cyt-b5 PF00173.23 EWC47345.1 - 1e-12 47.6 0.0 1.2e-12 47.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Seipin PF06775.9 EWC47347.1 - 4.8e-50 169.8 0.2 6.2e-50 169.4 0.2 1.1 1 0 0 1 1 1 1 Putative adipose-regulatory protein (Seipin) Peptidase_M50 PF02163.17 EWC47347.1 - 0.11 11.4 0.0 0.13 11.1 0.0 1.2 1 0 0 1 1 1 0 Peptidase family M50 Pex14_N PF04695.8 EWC47348.1 - 1.6e-30 105.9 0.1 1.6e-30 105.9 0.0 3.4 2 2 0 2 2 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region zf-C4H2 PF10146.4 EWC47348.1 - 4.9e-05 23.4 0.7 0.00015 21.8 0.3 1.9 2 0 0 2 2 2 1 Zinc finger-containing protein ERM PF00769.14 EWC47348.1 - 9.9e-05 21.9 1.9 0.00016 21.3 1.3 1.3 1 0 0 1 1 1 1 Ezrin/radixin/moesin family DUF3584 PF12128.3 EWC47348.1 - 0.0008 16.8 9.5 0.001 16.5 6.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) AAA_13 PF13166.1 EWC47348.1 - 0.033 12.6 4.6 0.044 12.2 3.2 1.0 1 0 0 1 1 1 0 AAA domain Spc7 PF08317.6 EWC47348.1 - 0.044 12.4 5.0 0.061 11.9 3.5 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein HAUS-augmin3 PF14932.1 EWC47348.1 - 0.099 11.8 2.9 0.14 11.2 2.0 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 tRNA-synt_His PF13393.1 EWC47348.1 - 0.1 11.6 3.7 0.065 12.2 1.3 1.5 1 1 1 2 2 2 0 Histidyl-tRNA synthetase Herpes_UL25 PF01499.11 EWC47348.1 - 0.13 10.5 7.8 3.1 6.0 5.4 2.1 1 1 0 1 1 1 0 Herpesvirus UL25 family GAS PF13851.1 EWC47348.1 - 0.31 10.2 7.5 0.49 9.5 5.2 1.3 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding IncA PF04156.9 EWC47348.1 - 0.36 10.3 7.6 0.6 9.6 5.3 1.3 1 0 0 1 1 1 0 IncA protein TMPIT PF07851.8 EWC47348.1 - 0.39 9.7 2.4 0.54 9.2 1.7 1.1 1 0 0 1 1 1 0 TMPIT-like protein DUF848 PF05852.6 EWC47348.1 - 0.63 9.8 6.1 0.98 9.2 4.2 1.3 1 0 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) Baculo_PEP_C PF04513.7 EWC47348.1 - 0.7 9.7 4.5 2.6 7.8 0.4 2.0 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Bacillus_HBL PF05791.6 EWC47348.1 - 1.3 8.4 3.9 2 7.7 2.7 1.3 1 0 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) Atg14 PF10186.4 EWC47348.1 - 6.2 5.6 6.3 9.9 5.0 4.4 1.3 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DivIC PF04977.10 EWC47348.1 - 7.6 6.0 9.3 4.4 6.8 1.2 2.9 1 1 1 2 2 2 0 Septum formation initiator Cyclin_N PF00134.18 EWC47349.1 - 6.4e-18 64.5 1.1 2.6e-17 62.5 0.3 2.1 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.14 EWC47349.1 - 1e-06 28.6 0.1 0.00013 21.8 0.0 2.5 2 1 0 2 2 2 1 Cyclin, C-terminal domain BsuPI PF12690.2 EWC47349.1 - 0.015 14.9 0.1 0.037 13.7 0.0 1.6 1 0 0 1 1 1 0 Intracellular proteinase inhibitor TFIIB PF00382.14 EWC47349.1 - 0.024 14.4 0.7 0.66 9.8 0.0 2.4 2 0 0 2 2 2 0 Transcription factor TFIIB repeat adh_short PF00106.20 EWC47351.1 - 5.1e-31 107.8 1.4 6.6e-31 107.4 1.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EWC47351.1 - 1.3e-25 90.5 0.7 1.7e-25 90.1 0.5 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EWC47351.1 - 3.3e-17 62.7 0.4 4.3e-17 62.3 0.3 1.1 1 0 0 1 1 1 1 KR domain 3HCDH_N PF02737.13 EWC47351.1 - 0.00036 20.2 0.7 0.00052 19.7 0.5 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AdoHcyase_NAD PF00670.16 EWC47351.1 - 0.002 18.0 0.7 0.0043 16.9 0.5 1.5 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain UDPG_MGDP_dh_N PF03721.9 EWC47351.1 - 0.11 11.8 0.1 0.18 11.1 0.1 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain MRP-L28 PF09812.4 EWC47352.1 - 2.6e-18 66.3 1.8 3.8e-18 65.7 1.2 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L28 Vps35 PF03635.12 EWC47353.1 - 1.5e-298 992.2 16.6 9.8e-298 989.5 11.5 1.8 1 1 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 AA_permease_2 PF13520.1 EWC47354.1 - 3.7e-54 183.8 57.9 4.8e-54 183.5 40.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EWC47354.1 - 7e-17 60.9 49.6 1.3e-16 60.0 34.4 1.4 1 1 0 1 1 1 1 Amino acid permease DUF3040 PF11239.3 EWC47354.1 - 3.1 7.9 6.8 3.1 7.9 0.3 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3040) TPR_12 PF13424.1 EWC47356.1 - 0.0008 19.2 0.1 0.23 11.4 0.0 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat DUF3907 PF13047.1 EWC47356.1 - 0.041 13.5 0.2 0.11 12.1 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3907) TPR_7 PF13176.1 EWC47356.1 - 0.096 12.5 2.8 3.5 7.6 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.12 EWC47356.1 - 2.6 8.1 5.0 53 4.0 0.0 4.3 5 0 0 5 5 5 0 Tetratricopeptide repeat Methyltransf_3 PF01596.12 EWC47357.1 - 2.9e-52 176.7 0.1 3.3e-52 176.5 0.0 1.0 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.1 EWC47357.1 - 9.6e-16 58.5 0.0 2e-15 57.5 0.0 1.5 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EWC47357.1 - 1.7e-11 44.6 0.4 4e-11 43.4 0.1 1.7 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EWC47357.1 - 1.3e-10 41.0 0.2 3.2e-10 39.7 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_26 PF13659.1 EWC47357.1 - 2.5e-07 30.7 0.0 4.3e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EWC47357.1 - 0.00012 22.4 0.0 0.00042 20.6 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain CmcI PF04989.7 EWC47357.1 - 0.00034 19.9 0.0 0.00051 19.4 0.0 1.2 1 0 0 1 1 1 1 Cephalosporin hydroxylase Methyltransf_11 PF08241.7 EWC47357.1 - 0.00086 19.7 0.9 0.0044 17.4 0.0 2.3 3 0 0 3 3 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 EWC47357.1 - 0.0017 18.7 0.1 0.0044 17.4 0.0 1.7 2 0 0 2 2 1 1 Methyltransferase domain PCMT PF01135.14 EWC47357.1 - 0.0024 17.4 0.0 0.0031 17.0 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_15 PF09445.5 EWC47357.1 - 0.0033 17.0 0.0 0.0045 16.5 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase MTS PF05175.9 EWC47357.1 - 0.004 16.5 0.0 0.006 15.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_16 PF10294.4 EWC47357.1 - 0.01 15.3 0.0 0.015 14.8 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase CheR PF01739.13 EWC47357.1 - 0.057 12.6 0.0 0.097 11.9 0.0 1.3 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain FmrO PF07091.6 EWC47357.1 - 0.077 11.9 0.0 0.096 11.6 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA methyltransferase (FmrO) Spermine_synth PF01564.12 EWC47357.1 - 0.12 11.2 0.0 0.17 10.8 0.0 1.3 1 0 0 1 1 1 0 Spermine/spermidine synthase PRT_C PF08372.5 EWC47358.1 - 0.0017 17.8 1.7 0.0067 15.9 0.0 2.1 2 0 0 2 2 2 1 Plant phosphoribosyltransferase C-terminal GRAM PF02893.15 EWC47358.1 - 0.087 12.3 0.0 0.23 11.0 0.0 1.7 1 0 0 1 1 1 0 GRAM domain GWT1 PF06423.7 EWC47358.1 - 0.1 12.7 0.1 0.31 11.1 0.1 1.7 1 0 0 1 1 1 0 GWT1 DUF3292 PF11696.3 EWC47358.1 - 0.19 9.5 6.3 0.81 7.4 1.8 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3292) DUF3449 PF11931.3 EWC47359.1 - 4.4e-72 241.7 1.9 8.1e-72 240.8 0.2 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF3449) SF3a60_bindingd PF12108.3 EWC47359.1 - 1.1e-12 47.2 0.6 1.1e-12 47.2 0.4 2.1 2 0 0 2 2 2 1 Splicing factor SF3a60 binding domain zf-met PF12874.2 EWC47359.1 - 1.7e-10 40.7 4.9 7.6e-09 35.4 0.6 2.5 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 EWC47359.1 - 1.4e-07 31.3 0.5 1.4e-07 31.3 0.3 2.4 2 1 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.2 EWC47359.1 - 0.00038 20.5 0.7 0.033 14.3 0.0 2.6 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) DUF951 PF06107.6 EWC47359.1 - 0.12 11.8 0.0 0.27 10.7 0.0 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF951) Use1 PF09753.4 EWC47359.1 - 0.15 11.4 3.7 0.31 10.4 2.6 1.5 1 0 0 1 1 1 0 Membrane fusion protein Use1 Myb_CC_LHEQLE PF14379.1 EWC47359.1 - 0.38 10.3 3.2 3 7.4 2.2 2.4 1 1 0 1 1 1 0 MYB-CC type transfactor, LHEQLE motif zf-C2H2_4 PF13894.1 EWC47359.1 - 0.39 11.1 4.6 1.7 9.1 0.3 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger C1_2 PF03107.11 EWC47359.1 - 1.9 8.6 6.0 4.9 7.3 0.3 2.4 2 0 0 2 2 2 0 C1 domain zf-C2H2 PF00096.21 EWC47359.1 - 3.2 8.2 5.2 4.2 7.9 0.4 2.6 2 0 0 2 2 2 0 Zinc finger, C2H2 type DEAD PF00270.24 EWC47360.1 - 2.8e-41 140.8 0.4 6.3e-41 139.6 0.2 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EWC47360.1 - 2.6e-28 97.6 0.2 5.4e-28 96.6 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_19 PF13245.1 EWC47360.1 - 0.0015 18.2 0.1 0.0035 17.0 0.1 1.7 1 0 0 1 1 1 1 Part of AAA domain ResIII PF04851.10 EWC47360.1 - 0.0021 17.8 0.1 0.0057 16.5 0.0 1.8 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.1 EWC47360.1 - 0.0049 16.4 0.2 0.012 15.2 0.1 1.5 1 1 0 1 1 1 1 AAA domain Flavi_DEAD PF07652.9 EWC47360.1 - 0.022 14.4 0.9 0.064 13.0 0.1 2.2 2 2 0 2 2 2 0 Flavivirus DEAD domain Helicase_RecD PF05127.9 EWC47360.1 - 0.03 13.9 0.0 0.054 13.1 0.0 1.5 1 0 0 1 1 1 0 Helicase DUF1253 PF06862.7 EWC47360.1 - 0.037 12.4 0.0 0.6 8.4 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1253) SNF2_N PF00176.18 EWC47360.1 - 0.044 12.5 0.0 0.068 11.9 0.0 1.2 1 0 0 1 1 1 0 SNF2 family N-terminal domain AAA_11 PF13086.1 EWC47360.1 - 0.061 12.8 0.4 0.089 12.3 0.3 1.6 1 1 0 1 1 1 0 AAA domain tRNA-synt_1b PF00579.20 EWC47360.1 - 0.078 12.0 0.0 0.18 10.9 0.0 1.6 2 0 0 2 2 2 0 tRNA synthetases class I (W and Y) AAA_22 PF13401.1 EWC47360.1 - 0.11 12.5 0.7 0.51 10.4 0.5 2.0 1 1 0 1 1 1 0 AAA domain RmlD_sub_bind PF04321.12 EWC47361.1 - 1.1e-54 185.2 0.0 1.4e-54 184.9 0.0 1.0 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.16 EWC47361.1 - 1.3e-22 80.3 0.0 1.6e-22 80.1 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 EWC47361.1 - 3.8e-09 36.8 0.0 5.1e-09 36.3 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding NAD_binding_4 PF07993.7 EWC47361.1 - 1.5e-08 33.8 0.0 9e-06 24.7 0.0 2.2 2 0 0 2 2 2 2 Male sterility protein 3Beta_HSD PF01073.14 EWC47361.1 - 6.7e-07 28.2 0.0 2.9e-06 26.2 0.0 1.8 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.10 EWC47361.1 - 5.7e-06 25.4 0.0 0.005 15.7 0.0 3.0 2 1 0 2 2 2 2 Polysaccharide biosynthesis protein adh_short PF00106.20 EWC47361.1 - 6.5e-05 22.9 0.5 0.0021 18.0 0.3 2.3 1 1 0 1 1 1 1 short chain dehydrogenase NmrA PF05368.8 EWC47361.1 - 0.011 14.9 1.2 0.021 14.0 0.2 1.7 2 0 0 2 2 2 0 NmrA-like family DapB_N PF01113.15 EWC47361.1 - 0.031 14.2 0.0 0.055 13.3 0.0 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Tau95 PF09734.4 EWC47362.1 - 4.3e-58 197.0 0.0 5.4e-58 196.7 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase III transcription factor (TF)IIIC subunit GFO_IDH_MocA PF01408.17 EWC47363.1 - 1.3e-19 70.9 0.1 1.8e-19 70.3 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Syntaxin-6_N PF09177.6 EWC47364.1 - 2.3e-21 76.0 0.9 1.9e-20 73.0 0.0 2.2 2 0 0 2 2 2 1 Syntaxin 6, N-terminal SNARE PF05739.14 EWC47364.1 - 8.6e-12 44.5 4.5 1.1e-11 44.2 1.7 2.1 2 0 0 2 2 2 1 SNARE domain TBCA PF02970.11 EWC47364.1 - 0.003 17.6 4.3 0.058 13.4 0.9 2.5 2 1 0 2 2 2 2 Tubulin binding cofactor A TPR_11 PF13414.1 EWC47365.1 - 7.5e-28 95.9 11.8 2.7e-10 39.7 0.0 7.9 7 2 1 8 8 8 5 TPR repeat TPR_1 PF00515.23 EWC47365.1 - 6.1e-26 88.9 2.9 4e-06 26.1 0.6 9.2 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_2 PF07719.12 EWC47365.1 - 7e-26 88.0 9.7 6.6e-05 22.5 0.2 11.2 11 1 1 12 12 12 4 Tetratricopeptide repeat Apc3 PF12895.2 EWC47365.1 - 2.8e-25 88.2 13.5 1e-19 70.4 0.2 5.6 4 2 2 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.1 EWC47365.1 - 9.7e-19 67.1 10.0 2.8e-06 27.1 0.0 8.0 5 4 2 7 7 7 4 Tetratricopeptide repeat TPR_16 PF13432.1 EWC47365.1 - 2.1e-17 63.2 0.3 0.0019 18.7 0.0 6.7 7 1 1 8 8 6 3 Tetratricopeptide repeat TPR_19 PF14559.1 EWC47365.1 - 2e-16 60.0 5.6 0.042 14.1 0.0 7.1 5 2 2 7 7 7 5 Tetratricopeptide repeat TPR_8 PF13181.1 EWC47365.1 - 3.6e-15 54.5 5.2 3.4e-05 23.3 0.7 6.5 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_7 PF13176.1 EWC47365.1 - 8.1e-13 47.1 8.8 0.012 15.3 0.0 8.0 7 2 1 8 8 7 2 Tetratricopeptide repeat TPR_14 PF13428.1 EWC47365.1 - 5.6e-12 45.1 5.3 0.26 12.0 0.0 9.0 7 2 4 11 11 11 2 Tetratricopeptide repeat TPR_17 PF13431.1 EWC47365.1 - 6.3e-09 35.3 0.1 2.5 8.5 0.0 7.5 7 1 0 7 7 7 1 Tetratricopeptide repeat TPR_6 PF13174.1 EWC47365.1 - 8.9e-07 28.9 10.4 0.1 13.1 0.4 6.6 7 0 0 7 7 5 1 Tetratricopeptide repeat TPR_10 PF13374.1 EWC47365.1 - 2.3e-05 24.1 11.2 0.026 14.4 0.1 6.3 8 0 0 8 8 5 1 Tetratricopeptide repeat TPR_15 PF13429.1 EWC47365.1 - 4.5e-05 22.6 1.7 0.12 11.3 0.2 4.3 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_21 PF09976.4 EWC47365.1 - 7.2e-05 22.7 9.5 0.0005 20.0 0.9 4.3 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_4 PF07721.9 EWC47365.1 - 0.0008 19.6 0.0 0.88 10.1 0.0 4.7 4 0 0 4 4 4 1 Tetratricopeptide repeat RPN7 PF10602.4 EWC47365.1 - 0.0028 17.0 0.9 6.3 6.1 0.0 3.8 3 1 0 3 3 3 1 26S proteasome subunit RPN7 TPR_9 PF13371.1 EWC47365.1 - 0.007 16.1 1.2 26 4.7 0.0 5.0 4 3 1 5 5 5 0 Tetratricopeptide repeat TPR_20 PF14561.1 EWC47365.1 - 0.083 13.0 1.1 76 3.5 0.0 4.6 5 1 1 6 6 5 0 Tetratricopeptide repeat Rubis-subs-bind PF09273.6 EWC47365.1 - 0.1 12.4 0.0 0.32 10.9 0.0 1.8 1 0 0 1 1 1 0 Rubisco LSMT substrate-binding F_bP_aldolase PF01116.15 EWC47365.1 - 0.11 11.6 0.0 0.2 10.7 0.0 1.4 1 0 0 1 1 1 0 Fructose-bisphosphate aldolase class-II Fis1_TPR_C PF14853.1 EWC47365.1 - 3.1 7.7 11.2 19 5.2 0.1 5.1 6 0 0 6 6 6 0 Fis1 C-terminal tetratricopeptide repeat MIT PF04212.13 EWC47365.1 - 3.5 7.5 6.0 19 5.2 0.7 3.7 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain CoaE PF01121.15 EWC47366.1 - 1.3e-43 148.5 0.0 2.3e-43 147.6 0.0 1.4 1 1 0 1 1 1 1 Dephospho-CoA kinase AAA_17 PF13207.1 EWC47366.1 - 0.004 17.9 0.1 0.015 16.0 0.1 2.2 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 EWC47366.1 - 0.025 14.9 0.6 0.14 12.4 0.4 2.2 1 1 0 1 1 1 0 AAA domain SKI PF01202.17 EWC47366.1 - 0.061 13.1 0.0 6.5 6.6 0.0 2.5 3 0 0 3 3 3 0 Shikimate kinase DUF2621 PF11084.3 EWC47366.1 - 0.12 12.0 0.7 5.8 6.5 0.0 3.0 4 0 0 4 4 4 0 Protein of unknown function (DUF2621) B56 PF01603.15 EWC47367.1 - 5.7e-172 571.9 2.1 7.3e-172 571.5 1.5 1.1 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) ATP-synt_ab PF00006.20 EWC47368.1 - 1.2e-112 374.6 0.0 1.7e-112 374.1 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 EWC47368.1 - 8.8e-17 61.6 0.1 1.5e-16 60.8 0.1 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.18 EWC47368.1 - 8.7e-08 32.2 1.2 3.6e-07 30.2 0.5 2.3 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain Biotin_lipoyl PF00364.17 EWC47368.1 - 0.055 13.1 0.0 2.9 7.5 0.0 2.6 2 0 0 2 2 2 0 Biotin-requiring enzyme AAA_14 PF13173.1 EWC47368.1 - 0.092 12.6 0.0 0.26 11.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.22 EWC47368.1 - 0.16 12.2 0.0 0.44 10.8 0.0 1.7 2 0 0 2 2 2 0 ABC transporter WD40 PF00400.27 EWC47369.1 - 1.6e-48 160.9 16.9 2.6e-12 46.1 0.7 6.5 6 0 0 6 6 6 5 WD domain, G-beta repeat eIF2A PF08662.6 EWC47369.1 - 7e-08 32.3 0.9 5.8e-06 26.1 0.1 3.0 1 1 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A CLTH PF10607.4 EWC47369.1 - 2.1e-06 27.4 0.8 3.8e-06 26.6 0.5 1.4 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain PD40 PF07676.7 EWC47369.1 - 0.00053 19.5 0.1 6.5 6.5 0.0 4.2 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat DUF3312 PF11768.3 EWC47369.1 - 0.0013 17.0 0.0 1.1 7.3 0.0 2.3 1 1 1 2 2 2 2 Protein of unknown function (DUF3312) Coatomer_WDAD PF04053.9 EWC47369.1 - 0.048 12.4 0.4 0.36 9.5 0.0 2.3 1 1 1 2 2 2 0 Coatomer WD associated region Pectate_lyase_3 PF12708.2 EWC47372.1 - 4.1e-76 256.0 16.1 5e-63 213.2 7.0 4.4 4 1 0 5 5 5 2 Pectate lyase superfamily protein End_N_terminal PF12218.3 EWC47372.1 - 1.8e-05 24.1 2.7 0.036 13.5 0.0 2.6 2 0 0 2 2 2 2 N terminal extension of bacteriophage endosialidase DUF1489 PF07370.6 EWC47372.1 - 0.034 13.6 0.3 73 2.8 0.0 4.4 5 0 0 5 5 5 0 Protein of unknown function (DUF1489) A_amylase_inhib PF01356.14 EWC47372.1 - 0.5 10.1 19.7 1.4 8.7 0.3 5.1 5 0 0 5 5 5 0 Alpha amylase inhibitor Yippee-Mis18 PF03226.9 EWC47372.1 - 8.8 6.4 15.0 1.4 8.9 0.2 4.5 4 0 0 4 4 4 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Dynamin_M PF01031.15 EWC47374.1 - 3.6e-105 350.9 3.9 2.1e-104 348.4 0.0 2.4 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.18 EWC47374.1 - 9.7e-55 184.9 0.1 2.2e-54 183.7 0.1 1.6 1 0 0 1 1 1 1 Dynamin family GED PF02212.13 EWC47374.1 - 3.2e-29 100.6 5.1 3.2e-29 100.6 3.5 2.0 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.18 EWC47374.1 - 0.00065 19.6 3.4 0.0017 18.2 0.6 2.7 2 1 0 2 2 2 1 50S ribosome-binding GTPase Miro PF08477.8 EWC47374.1 - 0.01 16.3 0.0 0.031 14.7 0.0 1.9 2 0 0 2 2 2 0 Miro-like protein AIG1 PF04548.11 EWC47374.1 - 0.038 13.0 0.3 3.9 6.5 0.0 2.6 2 0 0 2 2 2 0 AIG1 family MCM PF00493.18 EWC47375.1 - 1.5e-142 474.2 0.4 1.9e-142 473.9 0.3 1.1 1 0 0 1 1 1 1 MCM2/3/5 family MCM_N PF14551.1 EWC47375.1 - 2e-22 79.9 0.0 5.4e-22 78.5 0.0 1.8 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.16 EWC47375.1 - 8.1e-06 25.1 0.0 0.0018 17.4 0.0 2.5 1 1 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 EWC47375.1 - 2e-05 24.3 0.0 4.8e-05 23.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.6 EWC47375.1 - 0.00095 18.7 0.0 0.0048 16.5 0.0 2.2 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA PF00004.24 EWC47375.1 - 0.036 14.2 0.4 1.7 8.8 0.0 2.7 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Mg_chelatase_2 PF13335.1 EWC47375.1 - 0.29 11.5 4.3 0.22 11.9 0.6 2.5 2 1 0 2 2 2 0 Magnesium chelatase, subunit ChlI Vps54 PF07928.7 EWC47376.1 - 3.9e-48 163.0 0.0 1.1e-47 161.5 0.0 1.9 1 0 0 1 1 1 1 Vps54-like protein DUF2450 PF10475.4 EWC47376.1 - 1e-05 24.5 0.9 3.8e-05 22.7 0.3 2.2 3 0 0 3 3 3 1 Protein of unknown function N-terminal domain (DUF2450) DUF2451 PF10474.4 EWC47376.1 - 0.0038 17.0 0.0 0.009 15.7 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function C-terminus (DUF2451) CENP-F_leu_zip PF10473.4 EWC47376.1 - 0.097 12.5 1.4 0.23 11.3 1.0 1.5 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TPR_14 PF13428.1 EWC47376.1 - 1.4 9.7 5.2 36 5.3 0.1 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat NUDIX_2 PF13869.1 EWC47377.1 - 1.4e-80 269.0 0.0 1.7e-80 268.7 0.0 1.1 1 0 0 1 1 1 1 Nucleotide hydrolase Methyltransf_32 PF13679.1 EWC47378.1 - 6.7e-24 84.1 0.0 1.6e-23 82.9 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Glyco_transf_90 PF05686.7 EWC47379.1 - 5.2e-17 61.6 0.0 3.1e-15 55.7 0.0 2.4 2 0 0 2 2 2 2 Glycosyl transferase family 90 CN_hydrolase PF00795.17 EWC47380.1 - 5.9e-28 97.4 0.0 8.9e-28 96.8 0.0 1.3 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase NAD_synthase PF02540.12 EWC47380.1 - 9.5e-25 86.8 0.0 2.6e-24 85.4 0.0 1.6 1 1 0 1 1 1 1 NAD synthase Asn_synthase PF00733.16 EWC47380.1 - 0.00034 20.1 0.0 0.00057 19.4 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase TrkH PF02386.11 EWC47381.1 - 2.7e-119 397.8 17.1 2.9e-116 387.9 6.3 2.1 2 0 0 2 2 2 2 Cation transport protein HBS1_N PF08938.5 EWC47382.1 - 1.5 8.9 5.2 1.1 9.4 0.1 2.7 2 1 0 2 2 2 0 HBS1 N-terminus SRR1 PF07985.7 EWC47383.1 - 4e-06 26.6 0.0 7.4e-06 25.7 0.0 1.5 1 1 0 1 1 1 1 SRR1 DNA_ligase_A_M PF01068.16 EWC47384.1 - 1.8e-16 60.1 0.0 2.9e-16 59.4 0.0 1.3 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.9 EWC47384.1 - 2e-10 40.7 0.0 1.9e-09 37.6 0.0 2.5 2 1 0 2 2 2 1 DNA ligase N terminus COX5A PF02284.11 EWC47385.1 - 1.4e-41 140.8 0.2 1.7e-41 140.5 0.2 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Va ELO PF01151.13 EWC47386.1 - 1.6e-60 204.5 24.4 2e-60 204.1 16.9 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family Glyco_transf_4 PF13439.1 EWC47386.1 - 0.017 14.8 0.4 2.5 7.8 0.0 2.3 2 0 0 2 2 2 0 Glycosyltransferase Family 4 GST_N_3 PF13417.1 EWC47387.1 - 5.1e-14 52.2 0.0 8.7e-14 51.5 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 EWC47387.1 - 5.3e-11 42.3 0.0 8.5e-11 41.6 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.15 EWC47387.1 - 5.3e-06 26.5 0.0 1.5e-05 25.0 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Glutaredoxin PF00462.19 EWC47387.1 - 0.0039 17.1 0.0 0.0078 16.1 0.0 1.5 1 0 0 1 1 1 1 Glutaredoxin F-box-like PF12937.2 EWC47388.1 - 2.8e-09 36.5 1.3 2.2e-08 33.6 0.0 2.7 2 1 0 2 2 2 1 F-box-like F-box PF00646.28 EWC47388.1 - 0.34 10.6 5.4 35 4.2 0.2 3.5 3 0 0 3 3 3 0 F-box domain zf-RanBP PF00641.13 EWC47389.1 - 5e-18 63.8 11.0 5.5e-10 38.1 1.1 2.3 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others RRM_1 PF00076.17 EWC47389.1 - 2.5e-08 33.4 0.0 5.2e-08 32.4 0.0 1.6 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNase_T PF00929.19 EWC47389.1 - 9.6e-08 32.4 0.0 1.5e-07 31.8 0.0 1.3 1 0 0 1 1 1 1 Exonuclease RRM_6 PF14259.1 EWC47389.1 - 2.7e-06 27.2 0.0 5.2e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) DZR PF12773.2 EWC47389.1 - 0.37 10.6 8.3 0.67 9.8 0.8 2.4 2 0 0 2 2 2 0 Double zinc ribbon DUF572 PF04502.8 EWC47390.1 - 1.6e-78 264.1 10.4 1.9e-78 263.9 7.2 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) DNA_RNApol_7kD PF03604.8 EWC47390.1 - 0.013 14.9 2.0 1.5 8.3 0.4 2.5 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit Joubert PF15392.1 EWC47390.1 - 0.014 14.6 0.1 0.022 14.0 0.1 1.2 1 0 0 1 1 1 0 Joubert syndrome-associated Benyvirus_14KDa PF07255.6 EWC47390.1 - 0.02 14.7 0.9 0.078 12.8 0.6 1.8 1 1 0 1 1 1 0 Benyvirus 14KDa protein DUF866 PF05907.8 EWC47390.1 - 0.053 13.0 0.4 0.053 13.0 0.3 1.9 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF866) zf-FCS PF06467.9 EWC47390.1 - 0.34 10.5 2.3 1.1 8.8 0.1 2.2 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif NAD_binding_10 PF13460.1 EWC47392.1 - 2.8e-18 66.5 0.0 4.6e-18 65.8 0.0 1.3 1 0 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 EWC47392.1 - 6e-07 28.9 0.0 8.3e-05 21.9 0.0 2.2 2 0 0 2 2 2 2 NmrA-like family Epimerase PF01370.16 EWC47392.1 - 1.4e-05 24.6 0.0 0.017 14.5 0.0 2.2 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family Saccharop_dh PF03435.13 EWC47392.1 - 1.5e-05 24.1 0.0 2.3e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase TrkA_N PF02254.13 EWC47392.1 - 0.00093 19.1 0.0 0.0017 18.3 0.0 1.5 1 0 0 1 1 1 1 TrkA-N domain Fibrillarin PF01269.12 EWC47392.1 - 0.0013 17.7 0.0 0.002 17.0 0.0 1.2 1 0 0 1 1 1 1 Fibrillarin RmlD_sub_bind PF04321.12 EWC47392.1 - 0.0035 16.2 0.0 0.28 10.0 0.0 2.1 2 0 0 2 2 2 1 RmlD substrate binding domain DapB_N PF01113.15 EWC47392.1 - 0.0058 16.5 0.0 0.013 15.3 0.0 1.6 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus 3Beta_HSD PF01073.14 EWC47392.1 - 0.048 12.3 0.0 0.081 11.6 0.0 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.7 EWC47392.1 - 0.085 11.7 0.0 0.73 8.7 0.0 2.2 2 1 0 2 2 2 0 Male sterility protein UDPG_MGDP_dh_N PF03721.9 EWC47392.1 - 0.11 11.8 0.0 0.19 11.0 0.0 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Abhydrolase_5 PF12695.2 EWC47393.1 - 2.8e-10 40.1 0.0 4.1e-10 39.5 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 EWC47393.1 - 9.1e-09 35.5 0.0 1.1e-08 35.1 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family PhoPQ_related PF10142.4 EWC47393.1 - 0.007 14.8 0.0 0.011 14.2 0.0 1.2 1 0 0 1 1 1 1 PhoPQ-activated pathogenicity-related protein Peptidase_S9 PF00326.16 EWC47393.1 - 0.0075 15.5 0.0 0.19 10.9 0.0 2.2 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_4 PF08386.5 EWC47393.1 - 0.026 14.4 0.0 0.045 13.6 0.0 1.4 1 0 0 1 1 1 0 TAP-like protein VEFS-Box PF09733.4 EWC47396.1 - 2.4 7.8 4.7 0.9 9.1 0.2 2.0 2 0 0 2 2 2 0 VEFS-Box of polycomb protein adh_short PF00106.20 EWC47397.1 - 1.8e-07 31.2 0.0 2.7e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EWC47397.1 - 0.001 18.7 0.0 0.0017 18.0 0.0 1.3 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 EWC47397.1 - 0.1 12.3 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase MAPEG PF01124.13 EWC47398.1 - 6.7e-22 77.4 0.1 8.4e-22 77.1 0.1 1.1 1 0 0 1 1 1 1 MAPEG family Uds1 PF15456.1 EWC47399.1 - 0.81 9.6 5.7 0.13 12.2 0.7 2.0 2 0 0 2 2 2 0 Up-regulated During Septation UPF0047 PF01894.12 EWC47400.1 - 1.9e-38 130.9 0.0 3.2e-38 130.1 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised protein family UPF0047 Ribosomal_S21 PF01165.15 EWC47400.1 - 0.16 11.4 1.9 0.21 11.0 0.2 2.0 2 0 0 2 2 2 0 Ribosomal protein S21 UPF0029 PF01205.14 EWC47402.1 - 1.9e-18 66.1 0.0 2.9e-18 65.5 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 Chitin_bind_3 PF03067.10 EWC47403.1 - 0.033 14.4 0.0 0.063 13.5 0.0 1.5 1 0 0 1 1 1 0 Chitin binding domain DUF605 PF04652.11 EWC47403.1 - 1 8.6 5.0 1.5 8.1 3.4 1.1 1 0 0 1 1 1 0 Vta1 like DUF3433 PF11915.3 EWC47404.1 - 8.9e-36 121.9 11.1 9.2e-21 73.8 0.7 2.9 2 0 0 2 2 2 2 Protein of unknown function (DUF3433) Fungal_trans PF04082.13 EWC47405.1 - 5.5e-22 77.8 0.1 9e-22 77.1 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EWC47405.1 - 0.0046 16.8 9.5 0.0094 15.8 6.6 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FA_hydroxylase PF04116.8 EWC47406.1 - 8.6e-17 61.5 12.8 8.6e-17 61.5 8.9 1.9 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily Ribosomal_L4 PF00573.17 EWC47407.1 - 2.7e-40 137.7 0.3 2.7e-40 137.7 0.2 1.6 2 0 0 2 2 2 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.1 EWC47407.1 - 1.4e-26 92.1 0.8 3.4e-26 90.9 0.1 2.0 2 0 0 2 2 2 1 60S ribosomal protein L4 C-terminal domain SR-25 PF10500.4 EWC47408.1 - 0.00028 20.4 10.9 0.00028 20.4 7.6 3.6 3 1 0 4 4 4 1 Nuclear RNA-splicing-associated protein F-box-like PF12937.2 EWC47409.1 - 6e-08 32.2 0.0 6e-08 32.2 0.0 2.2 3 0 0 3 3 3 1 F-box-like F-box PF00646.28 EWC47409.1 - 0.008 15.8 0.0 0.008 15.8 0.0 2.3 3 0 0 3 3 3 1 F-box domain zf-CHCC PF10276.4 EWC47410.1 - 1.8e-16 59.6 1.5 2.6e-16 59.1 1.0 1.2 1 0 0 1 1 1 1 Zinc-finger domain Hydantoinase_A PF01968.13 EWC47410.1 - 0.073 12.1 0.0 0.09 11.8 0.0 1.1 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase NAP PF00956.13 EWC47411.1 - 4.2e-35 121.0 0.0 4.2e-35 121.0 0.0 1.6 2 1 0 2 2 2 1 Nucleosome assembly protein (NAP) Peptidase_M16 PF00675.15 EWC47413.1 - 1.7e-37 128.4 1.8 1.2e-36 125.7 0.1 2.5 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.16 EWC47413.1 - 8.6e-21 74.4 0.0 1.8e-16 60.3 0.0 3.5 4 0 0 4 4 4 2 Peptidase M16 inactive domain Pectate_lyase_3 PF12708.2 EWC47414.1 - 2.4e-75 253.4 23.2 2.8e-63 214.0 6.6 3.1 4 0 0 4 4 4 2 Pectate lyase superfamily protein End_N_terminal PF12218.3 EWC47414.1 - 2e-06 27.1 1.3 0.0061 16.0 0.3 2.7 2 0 0 2 2 2 2 N terminal extension of bacteriophage endosialidase zf-C2H2 PF00096.21 EWC47415.1 - 1.5e-07 31.3 36.7 0.0043 17.3 1.1 6.3 6 0 0 6 6 6 4 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.3 EWC47415.1 - 0.0049 16.9 0.9 0.031 14.4 0.7 2.5 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.1 EWC47415.1 - 0.018 15.3 1.1 0.018 15.3 0.8 6.8 6 1 1 7 7 7 0 C2H2-type zinc finger zf-C2H2_2 PF12756.2 EWC47415.1 - 0.027 14.5 3.6 5.5 7.1 0.0 3.5 2 2 1 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-FCS PF06467.9 EWC47415.1 - 0.15 11.7 10.4 1.2 8.7 0.3 4.0 4 0 0 4 4 4 0 MYM-type Zinc finger with FCS sequence motif Elf1 PF05129.8 EWC47415.1 - 0.16 11.6 4.2 0.37 10.5 0.6 2.9 3 0 0 3 3 3 0 Transcription elongation factor Elf1 like zf-met PF12874.2 EWC47415.1 - 1.2 9.4 8.0 0.19 12.0 0.6 3.2 3 0 0 3 3 3 0 Zinc-finger of C2H2 type Nucleotid_trans PF03407.11 EWC47416.1 - 0.00084 19.1 0.1 0.002 17.9 0.0 1.6 2 0 0 2 2 2 1 Nucleotide-diphospho-sugar transferase Gemini_AL1_M PF08283.6 EWC47417.1 - 0.13 12.0 0.0 0.26 11.1 0.0 1.4 1 0 0 1 1 1 0 Geminivirus rep protein central domain IPP-2 PF04979.9 EWC47419.1 - 1.3e-08 35.1 13.0 2.7e-06 27.6 0.2 2.7 3 0 0 3 3 3 2 Protein phosphatase inhibitor 2 (IPP-2) F-box-like PF12937.2 EWC47420.1 - 0.023 14.4 0.2 0.068 12.9 0.1 1.8 2 0 0 2 2 2 0 F-box-like EHN PF06441.7 EWC47421.1 - 5.6e-36 122.8 0.4 1.3e-34 118.4 0.0 2.2 2 0 0 2 2 2 1 Epoxide hydrolase N terminus Abhydrolase_6 PF12697.2 EWC47421.1 - 6.1e-08 32.8 1.4 1.4e-07 31.6 1.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EWC47421.1 - 0.0016 18.0 0.1 0.0041 16.7 0.1 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Malic_M PF03949.10 EWC47422.1 - 8.2e-83 277.8 0.0 1.3e-82 277.2 0.0 1.3 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.14 EWC47422.1 - 1.4e-67 226.8 0.0 2.2e-67 226.1 0.0 1.3 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain HD PF01966.17 EWC47424.1 - 1.5e-05 24.9 0.1 4.2e-05 23.5 0.1 1.8 1 1 0 1 1 1 1 HD domain DUF1534 PF07551.6 EWC47424.1 - 0.07 12.6 0.0 0.34 10.4 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1534) MFS_1 PF07690.11 EWC47425.1 - 6.2e-32 110.6 29.1 9.1e-32 110.1 20.2 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily CoA_transf_3 PF02515.12 EWC47425.1 - 0.094 11.9 0.2 0.24 10.6 0.1 1.6 1 0 0 1 1 1 0 CoA-transferase family III BRCT PF00533.21 EWC47426.1 - 9.1e-09 35.3 0.0 4.2e-08 33.2 0.0 2.2 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain Rad9_Rad53_bind PF08605.5 EWC47426.1 - 8e-07 28.9 0.0 1.4e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 Fungal Rad9-like Rad53-binding F-box-like PF12937.2 EWC47429.1 - 0.02 14.6 0.0 0.065 12.9 0.0 1.9 2 0 0 2 2 2 0 F-box-like Gtr1_RagA PF04670.7 EWC47430.1 - 1.6e-94 315.3 0.0 2.1e-94 315.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Sdh_cyt PF01127.17 EWC47430.1 - 2.1e-22 79.1 2.8 3.1e-22 78.6 1.2 1.8 2 0 0 2 2 2 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Miro PF08477.8 EWC47430.1 - 4.1e-06 27.2 0.0 9.6e-06 26.0 0.0 1.6 1 0 0 1 1 1 1 Miro-like protein Ras PF00071.17 EWC47430.1 - 6.6e-06 25.6 0.0 1.8e-05 24.1 0.0 1.7 2 0 0 2 2 2 1 Ras family MMR_HSR1 PF01926.18 EWC47430.1 - 7.2e-06 25.9 0.0 1.4e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.16 EWC47430.1 - 1.4e-05 24.3 0.0 2.2e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family AAA_29 PF13555.1 EWC47430.1 - 0.004 16.6 0.2 0.01 15.3 0.2 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF815 PF05673.8 EWC47430.1 - 0.02 13.7 0.0 0.033 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) ABC_tran PF00005.22 EWC47430.1 - 0.061 13.6 0.0 0.11 12.7 0.0 1.4 1 0 0 1 1 1 0 ABC transporter GTP_EFTU PF00009.22 EWC47430.1 - 0.091 12.1 0.0 0.24 10.7 0.0 1.6 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain DUF258 PF03193.11 EWC47430.1 - 0.16 11.1 0.0 0.29 10.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 Amidohydro_3 PF07969.6 EWC47431.1 - 6.1e-49 167.3 0.3 2.3e-48 165.4 0.2 1.8 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_4 PF13147.1 EWC47431.1 - 3.2e-11 43.7 0.9 3.2e-08 33.9 0.2 2.5 2 0 0 2 2 2 2 Amidohydrolase Amidohydro_1 PF01979.15 EWC47431.1 - 3.5e-09 36.7 0.2 2.7e-05 23.9 0.0 2.8 2 1 0 2 2 2 2 Amidohydrolase family Amidohydro_5 PF13594.1 EWC47431.1 - 0.0024 17.6 0.0 0.12 12.2 0.0 2.9 2 0 0 2 2 2 1 Amidohydrolase TonB_dep_Rec PF00593.19 EWC47431.1 - 0.0039 17.1 0.1 0.5 10.2 0.0 2.2 2 0 0 2 2 2 2 TonB dependent receptor Kelch_5 PF13854.1 EWC47432.1 - 2.7e-15 55.9 10.8 8.6e-05 22.4 0.2 6.4 6 0 0 6 6 6 3 Kelch motif Kelch_4 PF13418.1 EWC47432.1 - 1.8e-13 50.0 20.3 0.00011 21.8 0.1 7.1 6 1 0 6 6 6 3 Galactose oxidase, central domain Kelch_3 PF13415.1 EWC47432.1 - 1.5e-12 47.2 14.5 2.6e-05 24.2 0.3 5.3 5 0 0 5 5 5 4 Galactose oxidase, central domain SKG6 PF08693.5 EWC47432.1 - 1.6e-08 33.7 0.5 3e-08 32.8 0.4 1.4 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Kelch_1 PF01344.20 EWC47432.1 - 1.9e-07 30.4 13.6 0.00012 21.4 0.1 4.9 6 0 0 6 6 6 2 Kelch motif Kelch_6 PF13964.1 EWC47432.1 - 1.9e-06 27.7 16.3 0.08 13.1 0.1 5.9 5 1 0 5 5 5 3 Kelch motif Kelch_2 PF07646.10 EWC47432.1 - 0.00034 20.2 6.5 1.1 9.1 0.0 5.7 6 1 0 6 6 6 1 Kelch motif DUF4448 PF14610.1 EWC47432.1 - 0.013 15.0 0.0 0.023 14.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) DUF1546 PF07571.8 EWC47433.1 - 7.5e-27 93.2 0.0 6.5e-26 90.2 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF1546) TAF PF02969.12 EWC47433.1 - 5.2e-13 48.7 0.3 1.1e-12 47.6 0.2 1.6 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) Histone PF00125.19 EWC47433.1 - 0.005 16.9 0.1 0.012 15.6 0.1 1.7 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Dioxygenase_C PF00775.16 EWC47434.1 - 1.3e-46 158.1 0.0 1.8e-46 157.6 0.0 1.2 1 0 0 1 1 1 1 Dioxygenase Dioxygenase_N PF04444.9 EWC47434.1 - 1.8e-17 63.0 0.0 2.8e-17 62.4 0.0 1.3 1 0 0 1 1 1 1 Catechol dioxygenase N terminus Thiolase_N PF00108.18 EWC47435.1 - 3.3e-68 229.5 1.0 5e-66 222.3 0.2 2.6 2 1 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.13 EWC47435.1 - 7.5e-40 135.1 0.4 1.8e-39 133.9 0.3 1.6 1 0 0 1 1 1 1 Thiolase, C-terminal domain AAA PF00004.24 EWC47437.1 - 8.1e-19 68.1 0.0 2.2e-18 66.7 0.0 1.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 EWC47437.1 - 0.0012 19.0 0.1 0.022 14.8 0.0 3.0 3 1 0 3 3 3 1 AAA domain AAA_23 PF13476.1 EWC47437.1 - 0.0042 17.4 0.0 0.0086 16.4 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 EWC47437.1 - 0.021 14.5 0.0 0.072 12.8 0.0 1.9 1 0 0 1 1 1 0 Part of AAA domain AAA_16 PF13191.1 EWC47437.1 - 0.033 14.1 0.0 0.092 12.7 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain AAA_17 PF13207.1 EWC47437.1 - 0.046 14.5 0.0 0.2 12.4 0.0 2.1 2 1 0 2 2 2 0 AAA domain RNA_helicase PF00910.17 EWC47437.1 - 0.051 13.7 0.0 0.17 12.0 0.0 1.9 1 1 0 1 1 1 0 RNA helicase AAA_25 PF13481.1 EWC47437.1 - 0.11 11.9 0.0 0.99 8.7 0.0 2.2 1 1 1 2 2 2 0 AAA domain NACHT PF05729.7 EWC47437.1 - 0.13 11.8 0.0 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 NACHT domain RgpF PF05045.7 EWC47438.1 - 0.00061 18.4 0.1 0.0048 15.4 0.0 2.0 1 1 0 1 1 1 1 Rhamnan synthesis protein F Adap_comp_sub PF00928.16 EWC47439.1 - 3.1e-88 295.2 0.0 4.2e-88 294.8 0.0 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.15 EWC47439.1 - 2.2e-08 33.9 0.3 4e-08 33.0 0.2 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Glyco_trans_1_4 PF13692.1 EWC47442.1 - 4.8e-20 72.0 0.0 5.3e-19 68.7 0.0 2.4 3 0 0 3 3 3 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.1 EWC47442.1 - 1.1e-06 28.8 0.0 1.9e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glycos_transf_1 PF00534.15 EWC47442.1 - 0.00016 21.1 0.0 0.00028 20.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.1 EWC47442.1 - 0.053 13.7 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferases group 1 Helicase_C_3 PF13625.1 EWC47443.1 - 5.7e-26 90.7 0.0 2.3e-25 88.8 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 EWC47443.1 - 7.3e-14 52.0 0.0 1.6e-13 50.9 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.26 EWC47443.1 - 1.5e-11 43.9 0.0 3.9e-11 42.6 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.18 EWC47443.1 - 8.5e-10 37.9 0.1 1.4e-09 37.1 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Gluconate_2-dh3 PF13618.1 EWC47443.1 - 0.11 12.6 2.0 0.19 11.8 0.0 2.4 3 0 0 3 3 3 0 Gluconate 2-dehydrogenase subunit 3 DUF3246 PF11596.3 EWC47443.1 - 1.2 8.3 5.3 6.5 5.9 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3246) zf-C3HC4_2 PF13923.1 EWC47444.1 - 3.4 7.7 15.5 2 8.5 1.2 3.5 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Methyltransf_25 PF13649.1 EWC47446.1 - 2.1e-06 28.0 0.0 5.4e-06 26.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EWC47446.1 - 0.0047 16.6 0.0 0.008 15.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EWC47446.1 - 0.0058 17.0 0.0 0.012 16.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EWC47446.1 - 0.019 14.5 0.0 0.035 13.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.7 EWC47446.1 - 0.041 14.3 0.1 0.15 12.5 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase domain NIF3 PF01784.13 EWC47448.1 - 1.3e-60 204.9 0.0 1.7e-60 204.6 0.0 1.0 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) EppA_BapA PF07268.6 EWC47449.1 - 0.06 13.0 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 Exported protein precursor (EppA/BapA) RhgB_N PF09284.5 EWC47450.1 - 8.9e-96 320.0 3.8 1.5e-95 319.2 2.6 1.4 1 0 0 1 1 1 1 Rhamnogalacturonase B, N-terminal CBM-like PF14683.1 EWC47450.1 - 5.3e-52 175.8 0.0 5.3e-52 175.8 0.0 2.0 2 0 0 2 2 2 1 Polysaccharide lyase family 4, domain III fn3_3 PF14686.1 EWC47450.1 - 1.2e-14 54.2 2.0 1.8e-14 53.6 0.5 2.0 2 0 0 2 2 2 1 Polysaccharide lyase family 4, domain II CBM_1 PF00734.13 EWC47450.1 - 4.6e-13 48.5 16.1 1.3e-12 47.1 11.1 1.8 1 0 0 1 1 1 1 Fungal cellulose binding domain Ubie_methyltran PF01209.13 EWC47452.1 - 5.1e-13 48.6 0.0 4.1e-12 45.7 0.0 2.0 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.1 EWC47452.1 - 3.6e-11 43.3 0.1 5.8e-11 42.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EWC47452.1 - 1.3e-09 38.3 0.0 2e-09 37.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EWC47452.1 - 1e-06 28.4 0.0 1.3e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EWC47452.1 - 3.4e-05 23.6 0.0 5.6e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EWC47452.1 - 0.00014 22.4 0.0 0.00025 21.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EWC47452.1 - 0.00044 20.2 0.0 0.001 19.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EWC47452.1 - 0.017 15.6 0.0 0.025 15.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Phospholip_A2_3 PF09056.6 EWC47453.1 - 9.2e-27 93.4 0.1 1.3e-26 92.9 0.1 1.2 1 0 0 1 1 1 1 Prokaryotic phospholipase A2 DUF3430 PF11912.3 EWC47453.1 - 0.062 13.1 0.5 0.083 12.7 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3430) DUF4243 PF14027.1 EWC47454.1 - 5e-89 299.0 3.2 6.1e-89 298.7 2.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4243) KAT11 PF08214.6 EWC47456.1 - 5.3e-77 259.2 0.0 6.9e-77 258.8 0.0 1.1 1 0 0 1 1 1 1 Histone acetylation protein Ribonucleas_3_3 PF14622.1 EWC47457.1 - 3.9e-20 72.0 0.0 5.9e-19 68.2 0.0 2.0 1 1 0 1 1 1 1 Ribonuclease-III-like LDB19 PF13002.2 EWC47459.1 - 3.1e-11 43.1 0.1 5.7e-11 42.2 0.1 1.4 1 0 0 1 1 1 1 Arrestin_N terminal like Arrestin_N PF00339.24 EWC47459.1 - 1e-05 25.4 0.1 4.6e-05 23.2 0.0 1.9 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.17 EWC47459.1 - 0.12 12.4 0.2 0.9 9.6 0.0 2.1 2 0 0 2 2 2 0 Arrestin (or S-antigen), C-terminal domain HET PF06985.6 EWC47461.1 - 7.1e-32 110.4 0.7 1.5e-31 109.4 0.5 1.6 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) HATPase_c PF02518.21 EWC47461.1 - 0.14 11.8 0.0 0.29 10.8 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Prenyltrans_2 PF13249.1 EWC47462.1 - 1.4e-34 118.8 0.8 1.9e-10 41.1 0.0 5.5 2 2 4 6 6 6 6 Prenyltransferase-like Prenyltrans_1 PF13243.1 EWC47462.1 - 1.1e-30 105.8 0.7 2.1e-10 40.5 0.1 5.2 3 1 2 5 5 5 4 Prenyltransferase-like Prenyltrans PF00432.16 EWC47462.1 - 3.6e-27 93.5 13.4 2.5e-09 36.5 0.2 5.6 7 0 0 7 7 7 4 Prenyltransferase and squalene oxidase repeat Pec_lyase PF09492.5 EWC47462.1 - 5.1e-06 25.8 0.2 1.2 8.2 0.0 5.0 3 2 2 6 6 6 3 Pectic acid lyase A2M_comp PF07678.9 EWC47462.1 - 0.00095 18.4 0.1 0.32 10.2 0.0 3.5 2 2 2 4 4 4 1 A-macroglobulin complement component CBM_1 PF00734.13 EWC47464.1 - 6.8e-05 22.4 66.4 0.003 17.1 7.3 7.8 6 2 0 6 6 6 3 Fungal cellulose binding domain CAF1A PF12253.3 EWC47466.1 - 5.5e-20 71.2 2.0 5.5e-20 71.2 1.4 3.4 2 1 0 2 2 2 1 Chromatin assembly factor 1 subunit A CAF-1_p150 PF11600.3 EWC47466.1 - 4.1e-08 32.8 50.0 4.1e-08 32.8 34.6 2.9 3 0 0 3 3 3 1 Chromatin assembly factor 1 complex p150 subunit, N-terminal Hom_end_hint PF05203.11 EWC47466.1 - 0.0056 16.4 0.1 0.0056 16.4 0.1 1.2 1 0 0 1 1 1 1 Hom_end-associated Hint SAPS PF04499.10 EWC47466.1 - 0.1 11.2 7.3 0.16 10.5 5.1 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein EXS PF03124.9 EWC47467.1 - 3e-89 299.4 36.2 3.7e-89 299.1 25.1 1.1 1 0 0 1 1 1 1 EXS family SPX PF03105.14 EWC47467.1 - 2.4e-53 181.6 0.0 4.2e-53 180.9 0.0 1.4 1 1 0 1 1 1 1 SPX domain Borealin PF10512.4 EWC47467.1 - 1 9.2 4.1 3.1 7.7 1.5 2.4 1 1 1 2 2 2 0 Cell division cycle-associated protein 8 Ank PF00023.25 EWC47468.1 - 4.1e-18 64.1 2.0 2e-10 39.9 0.2 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.1 EWC47468.1 - 5.7e-16 57.0 0.2 8.4e-08 31.7 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.1 EWC47468.1 - 7.7e-16 57.7 3.0 8.1e-09 35.4 0.4 2.6 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.2 EWC47468.1 - 1e-15 57.8 0.5 1.1e-08 35.3 0.1 2.3 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 EWC47468.1 - 4.1e-14 52.6 0.7 1.1e-06 28.9 0.0 2.8 3 0 0 3 3 3 2 Ankyrin repeats (many copies) DUF3759 PF12585.3 EWC47469.1 - 4.8e-28 96.9 15.1 4.8e-28 96.9 10.4 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF3759) DUF3759 PF12585.3 EWC47470.1 - 8.4e-24 83.3 3.2 8.4e-24 83.3 2.2 1.6 1 1 1 2 2 2 1 Protein of unknown function (DUF3759) HABP4_PAI-RBP1 PF04774.10 EWC47470.1 - 0.02 15.3 0.4 0.041 14.3 0.3 1.5 1 0 0 1 1 1 0 Hyaluronan / mRNA binding family DUF3759 PF12585.3 EWC47471.1 - 2.8e-31 107.2 8.6 2.8e-31 107.2 5.9 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF3759) SR-25 PF10500.4 EWC47472.1 - 0.12 11.7 12.9 0.038 13.4 6.6 1.7 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein IncA PF04156.9 EWC47472.1 - 0.18 11.4 0.0 0.3 10.6 0.0 1.3 1 0 0 1 1 1 0 IncA protein DUF1688 PF07958.6 EWC47473.1 - 5.4e-168 558.8 0.0 6.2e-168 558.6 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1688) PQ-loop PF04193.9 EWC47474.1 - 3.6e-41 138.5 11.9 1.1e-20 72.9 1.6 2.7 2 0 0 2 2 2 2 PQ loop repeat D-aminoacyl_C PF07908.7 EWC47475.1 - 0.077 12.3 0.0 0.18 11.1 0.0 1.6 1 0 0 1 1 1 0 D-aminoacylase, C-terminal region SGS PF05002.10 EWC47477.1 - 8.5e-29 99.1 3.7 8.5e-29 99.1 2.6 2.0 2 1 0 2 2 2 1 SGS domain CS PF04969.11 EWC47477.1 - 3.8e-17 62.5 0.0 7.5e-17 61.6 0.0 1.5 1 0 0 1 1 1 1 CS domain TPR_11 PF13414.1 EWC47477.1 - 1.9e-09 37.0 1.1 1.9e-09 37.0 0.8 1.9 2 0 0 2 2 2 1 TPR repeat TPR_2 PF07719.12 EWC47477.1 - 0.001 18.8 3.8 0.12 12.3 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.23 EWC47477.1 - 0.0022 17.4 0.5 0.12 12.0 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.1 EWC47477.1 - 0.079 13.6 4.3 0.088 13.5 1.1 2.3 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.1 EWC47477.1 - 0.3 11.0 5.5 2.6 8.0 1.3 2.3 1 1 1 2 2 2 0 Tetratricopeptide repeat Fumarate_red_C PF02300.12 EWC47479.1 - 0.062 13.1 1.0 0.062 13.1 0.7 1.1 1 0 0 1 1 1 0 Fumarate reductase subunit C DUF939 PF06081.6 EWC47479.1 - 0.19 11.5 6.5 0.22 11.3 4.5 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF939) TrbC PF04956.8 EWC47479.1 - 0.42 10.6 6.4 0.55 10.2 4.4 1.2 1 0 0 1 1 1 0 TrbC/VIRB2 family SUR7 PF06687.7 EWC47479.1 - 2.5 7.6 6.5 2.5 7.6 4.5 1.0 1 0 0 1 1 1 0 SUR7/PalI family Apq12 PF12716.2 EWC47479.1 - 3.9 7.2 8.3 5.4 6.7 5.8 1.3 1 0 0 1 1 1 0 Nuclear pore assembly and biogenesis CENP-B_dimeris PF09026.5 EWC47480.1 - 0.006 16.8 1.0 0.017 15.3 0.7 1.7 1 0 0 1 1 1 1 Centromere protein B dimerisation domain PAN_4 PF14295.1 EWC47481.1 - 0.028 14.1 2.2 0.54 10.0 0.2 2.5 2 0 0 2 2 2 0 PAN domain Peptidase_S28 PF05577.7 EWC47482.1 - 7e-43 146.7 0.5 1e-41 142.9 0.3 2.0 1 1 0 1 1 1 1 Serine carboxypeptidase S28 NAD_binding_6 PF08030.7 EWC47483.1 - 1.8e-17 63.6 0.0 2.6e-17 63.1 0.0 1.2 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.14 EWC47483.1 - 4.6e-17 62.2 5.4 7.5e-17 61.5 3.8 1.3 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.7 EWC47483.1 - 3.8e-16 58.8 0.0 9.6e-16 57.5 0.0 1.7 1 0 0 1 1 1 1 FAD-binding domain Citrate_synt PF00285.16 EWC47484.1 - 0.051 12.3 1.1 0.091 11.4 0.8 1.3 1 0 0 1 1 1 0 Citrate synthase Borrelia_P83 PF05262.6 EWC47484.1 - 1.5 7.0 5.4 2.1 6.4 3.7 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein Metallophos PF00149.23 EWC47486.1 - 4.8e-43 146.8 0.7 7.4e-43 146.2 0.5 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Glyco_hydro_72 PF03198.9 EWC47488.1 - 2.7e-98 328.8 0.1 3.5e-98 328.4 0.1 1.1 1 0 0 1 1 1 1 Glucanosyltransferase lci PF12197.3 EWC47488.1 - 0.022 14.3 0.1 5.7 6.6 0.1 2.6 2 0 0 2 2 2 0 Bacillus cereus group antimicrobial protein Bax1-I PF01027.15 EWC47489.1 - 4.4e-30 104.8 14.7 1.9e-29 102.7 7.6 2.1 2 0 0 2 2 2 2 Inhibitor of apoptosis-promoting Bax1 WXG100 PF06013.7 EWC47490.1 - 0.061 13.3 0.3 0.21 11.6 0.0 2.1 2 1 0 2 2 2 0 Proteins of 100 residues with WXG Laminin_II PF06009.7 EWC47490.1 - 0.1 12.3 5.2 4.2 7.1 1.0 2.6 1 1 0 2 2 2 0 Laminin Domain II DUF948 PF06103.6 EWC47490.1 - 0.48 10.3 2.6 0.64 9.9 0.3 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Rho_Binding PF08912.6 EWC47490.1 - 2.5 8.4 5.9 3.3 8.0 0.7 2.6 2 0 0 2 2 2 0 Rho Binding APG6 PF04111.7 EWC47490.1 - 3.3 6.6 9.4 0.33 9.9 2.8 1.8 1 1 0 1 1 1 0 Autophagy protein Apg6 BLOC1_2 PF10046.4 EWC47490.1 - 5.6 7.1 8.0 2.4 8.3 2.6 2.5 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DivIVA PF05103.8 EWC47490.1 - 6.5 6.8 8.9 0.38 10.8 1.1 2.5 2 1 1 3 3 3 0 DivIVA protein Spectrin PF00435.16 EWC47490.1 - 6.6 7.0 12.6 6.3 7.1 1.3 3.3 1 1 1 3 3 3 0 Spectrin repeat DUF964 PF06133.6 EWC47490.1 - 9.5 6.2 10.3 15 5.6 0.3 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF964) DUF972 PF06156.8 EWC47490.1 - 9.6 6.6 8.7 6.4 7.1 0.4 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF972) Glyco_hydro_28 PF00295.12 EWC47492.1 - 1e-46 159.4 1.4 1.4e-46 159.0 1.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 BNR PF02012.15 EWC47493.1 - 5.9e-12 43.5 33.3 0.16 11.9 0.7 9.7 8 0 0 8 8 8 7 BNR/Asp-box repeat CBM_1 PF00734.13 EWC47493.1 - 5.3e-11 41.9 10.1 1.8e-10 40.3 7.0 2.0 1 0 0 1 1 1 1 Fungal cellulose binding domain Abhydrolase_2 PF02230.11 EWC47494.1 - 6.5e-15 55.1 0.0 8.6e-15 54.7 0.0 1.2 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_5 PF12695.2 EWC47494.1 - 0.0028 17.4 0.0 0.0037 17.0 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 EWC47494.1 - 0.055 13.3 0.0 0.29 10.9 0.0 1.8 1 1 0 1 1 1 0 Alpha/beta hydrolase family UQ_con PF00179.21 EWC47495.1 - 1.3e-46 157.5 0.0 1.4e-46 157.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 EWC47495.1 - 0.1 12.3 0.0 0.46 10.2 0.0 1.9 1 1 0 1 1 1 0 Prokaryotic E2 family B Colipase-like PF15083.1 EWC47496.1 - 0.041 13.7 0.6 0.081 12.8 0.4 1.4 1 0 0 1 1 1 0 Colipase-like KxDL PF10241.4 EWC47496.1 - 0.23 11.3 4.2 0.16 11.9 0.5 2.6 2 0 0 2 2 2 0 Uncharacterized conserved protein Peptidase_M18 PF02127.10 EWC47497.1 - 6.9e-128 426.8 0.0 8.8e-128 426.4 0.0 1.1 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) adh_short PF00106.20 EWC47498.1 - 5.1e-21 75.3 1.5 7.3e-21 74.7 1.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EWC47498.1 - 5.7e-21 75.3 1.2 3.5e-20 72.8 0.8 1.8 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EWC47498.1 - 3.1e-05 23.7 1.2 4.9e-05 23.0 0.5 1.6 1 1 0 1 1 1 1 KR domain 3HCDH_N PF02737.13 EWC47498.1 - 0.0065 16.1 0.8 0.011 15.4 0.6 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain RdRP PF05183.7 EWC47499.1 - 1.1e-101 341.3 0.0 1.8e-101 340.6 0.0 1.3 1 0 0 1 1 1 1 RNA dependent RNA polymerase DUF4064 PF13273.1 EWC47500.1 - 0.95 9.5 6.6 1.9 8.6 1.2 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) Yip1 PF04893.12 EWC47500.1 - 1.8 8.0 20.1 1.1 8.6 0.6 3.5 1 1 0 2 2 2 0 Yip1 domain Trypan_PARP PF05887.6 EWC47501.1 - 6.5 6.5 14.0 11 5.8 9.7 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Pectinesterase PF01095.14 EWC47502.1 - 2.6e-50 170.6 6.5 2.6e-50 170.6 4.5 1.7 2 0 0 2 2 2 1 Pectinesterase CBM_1 PF00734.13 EWC47502.1 - 6e-09 35.4 15.5 6e-09 35.4 10.7 2.2 2 0 0 2 2 2 1 Fungal cellulose binding domain Voldacs PF03517.8 EWC47503.1 - 1.4e-23 83.2 0.0 1.4e-23 83.2 0.0 2.5 3 0 0 3 3 3 1 Regulator of volume decrease after cellular swelling tRNA-synt_1e PF01406.14 EWC47504.1 - 3.8e-107 357.8 0.0 1.4e-106 356.0 0.0 1.9 2 1 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.6 EWC47504.1 - 5.6e-05 21.9 0.1 0.11 11.1 0.0 2.5 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1c PF00749.16 EWC47504.1 - 0.06 11.9 1.6 10 4.6 0.0 2.2 2 0 0 2 2 2 0 tRNA synthetases class I (E and Q), catalytic domain DUF1682 PF07946.9 EWC47504.1 - 0.38 9.5 6.0 0.65 8.7 4.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) GCD14 PF08704.5 EWC47505.1 - 3.4e-66 223.2 1.0 2.7e-33 115.5 0.0 3.2 2 1 1 3 3 3 3 tRNA methyltransferase complex GCD14 subunit Methyltransf_26 PF13659.1 EWC47505.1 - 7.2e-05 22.8 0.2 0.00021 21.3 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain TFIIF_alpha PF05793.7 EWC47505.1 - 0.0046 15.3 9.1 0.0065 14.8 6.3 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Methyltransf_18 PF12847.2 EWC47505.1 - 0.0096 16.4 0.0 6.3 7.4 0.0 2.8 2 0 0 2 2 2 2 Methyltransferase domain FancD2 PF14631.1 EWC47505.1 - 1.4 5.9 2.5 1.9 5.4 1.7 1.1 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease PBP1_TM PF14812.1 EWC47505.1 - 2.2 8.6 8.3 6.5 7.1 5.7 1.8 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Pro-kuma_activ PF09286.6 EWC47506.1 - 3.3e-20 72.5 0.0 7.4e-20 71.4 0.0 1.6 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.17 EWC47506.1 - 1.6e-05 24.2 0.1 2.6e-05 23.5 0.1 1.3 1 0 0 1 1 1 1 Subtilase family tRNA_int_endo PF01974.12 EWC47507.1 - 1.3e-20 72.9 0.3 2.5e-20 72.0 0.2 1.4 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain tRNA_int_endo_N PF02778.9 EWC47507.1 - 2e-05 24.0 0.0 0.00026 20.4 0.0 2.3 2 0 0 2 2 2 1 tRNA intron endonuclease, N-terminal domain FRQ PF09421.5 EWC47507.1 - 0.027 12.2 0.2 0.034 11.9 0.1 1.1 1 0 0 1 1 1 0 Frequency clock protein Ribosomal_L27 PF01016.14 EWC47509.1 - 4.6e-27 93.6 0.0 8.7e-27 92.7 0.0 1.5 1 0 0 1 1 1 1 Ribosomal L27 protein NOB1_Zn_bind PF08772.6 EWC47511.1 - 8.5e-28 96.0 2.8 1.4e-27 95.2 2.0 1.4 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like Rpr2 PF04032.11 EWC47511.1 - 0.025 14.4 0.3 0.058 13.2 0.2 1.6 1 0 0 1 1 1 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain PGBA_N PF15436.1 EWC47511.1 - 0.057 12.6 0.1 0.093 11.9 0.0 1.3 1 0 0 1 1 1 0 Plasminogen-binding protein pgbA N-terminal Nop10p PF04135.7 EWC47512.1 - 1.3e-19 69.6 0.1 1.6e-19 69.3 0.1 1.1 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family WW PF00397.21 EWC47513.1 - 9.4e-11 41.3 4.3 1.8e-10 40.4 3.0 1.5 1 0 0 1 1 1 1 WW domain DUF605 PF04652.11 EWC47513.1 - 7.8 5.7 17.9 3.3 6.9 10.9 1.5 1 1 0 1 1 1 0 Vta1 like TPR_11 PF13414.1 EWC47514.1 - 1.2e-09 37.6 0.0 2e-08 33.7 0.0 2.4 2 0 0 2 2 2 1 TPR repeat UBA PF00627.26 EWC47514.1 - 8.1e-06 25.5 0.0 2.9e-05 23.7 0.0 2.0 1 0 0 1 1 1 1 UBA/TS-N domain TPR_1 PF00515.23 EWC47514.1 - 0.00057 19.3 0.0 0.13 11.9 0.0 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.12 EWC47514.1 - 0.0016 18.2 0.2 32 4.7 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.1 EWC47514.1 - 0.0027 17.6 0.1 0.018 14.9 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat DnaJ PF00226.26 EWC47514.1 - 0.0092 15.6 0.0 0.028 14.1 0.0 1.8 1 0 0 1 1 1 1 DnaJ domain PHO4 PF01384.15 EWC47517.1 - 2.8e-100 335.1 16.6 3.3e-100 334.9 11.5 1.0 1 0 0 1 1 1 1 Phosphate transporter family Mito_carr PF00153.22 EWC47518.1 - 2.5e-45 152.0 7.9 9.6e-17 60.4 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF2048 PF09752.4 EWC47518.1 - 0.08 11.8 0.0 0.12 11.2 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2048) Glyco_hydro_61 PF03443.9 EWC47519.1 - 3.4e-60 203.5 0.8 4.3e-60 203.2 0.0 1.5 2 0 0 2 2 2 1 Glycosyl hydrolase family 61 CBM_1 PF00734.13 EWC47519.1 - 3.8e-10 39.2 10.3 1.6e-09 37.2 7.1 2.2 1 0 0 1 1 1 1 Fungal cellulose binding domain Bac_export_3 PF01313.14 EWC47521.1 - 0.019 14.6 0.1 0.027 14.1 0.1 1.1 1 0 0 1 1 1 0 Bacterial export proteins, family 3 DUF3357 PF11837.3 EWC47521.1 - 0.076 12.8 0.2 0.13 12.1 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3357) Dicty_REP PF05086.7 EWC47522.1 - 1.7 6.2 4.2 2.2 5.9 2.9 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein AT_hook PF02178.14 EWC47522.1 - 6.2 6.8 32.0 0.11 12.2 3.3 4.1 3 0 0 3 3 3 0 AT hook motif SH3_1 PF00018.23 EWC47524.1 - 1.6e-10 40.2 0.1 2.8e-10 39.3 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 EWC47524.1 - 8.4e-07 28.4 0.1 1.8e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 EWC47524.1 - 1.1e-05 24.8 0.1 2e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain DUF605 PF04652.11 EWC47525.1 - 9.3 5.5 16.3 12 5.1 11.3 1.2 1 0 0 1 1 1 0 Vta1 like Sugar_tr PF00083.19 EWC47526.1 - 2.8e-85 286.6 22.0 3.2e-85 286.4 15.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EWC47526.1 - 7.7e-40 136.6 43.1 2.4e-31 108.7 19.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.8 EWC47526.1 - 3.2e-05 22.3 5.2 0.01 14.0 0.1 2.1 2 0 0 2 2 2 2 Fungal trichothecene efflux pump (TRI12) Aldo_ket_red PF00248.16 EWC47528.1 - 3.3e-65 219.7 0.0 3.8e-65 219.5 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Claudin_3 PF06653.6 EWC47528.1 - 0.058 13.1 0.0 0.1 12.3 0.0 1.3 1 0 0 1 1 1 0 Tight junction protein, Claudin-like IF-2B PF01008.12 EWC47529.1 - 4.1e-12 45.6 0.0 1.2e-11 44.1 0.0 1.8 1 1 0 1 1 1 1 Initiation factor 2 subunit family DEAD PF00270.24 EWC47530.1 - 1.6e-21 76.5 0.0 2.7e-21 75.8 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF1998 PF09369.5 EWC47530.1 - 5.2e-14 52.5 0.0 1.5e-13 51.1 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1998) Helicase_C PF00271.26 EWC47530.1 - 1.1e-11 44.4 0.1 2.5e-11 43.2 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Terminase_GpA PF05876.7 EWC47530.1 - 0.11 10.7 0.0 0.18 10.1 0.0 1.2 1 0 0 1 1 1 0 Phage terminase large subunit (GpA) Wbp11 PF09429.5 EWC47532.1 - 3.2e-16 59.0 13.4 3.2e-16 59.0 9.3 1.8 2 0 0 2 2 2 1 WW domain binding protein 11 OmpH PF03938.9 EWC47532.1 - 4e-05 23.5 1.8 0.00017 21.5 0.3 1.9 2 0 0 2 2 2 1 Outer membrane protein (OmpH-like) DUF3040 PF11239.3 EWC47532.1 - 0.17 11.9 0.2 0.17 11.9 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) DUF2946 PF11162.3 EWC47532.1 - 0.61 10.2 6.5 9.1 6.5 0.4 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2946) DUF3450 PF11932.3 EWC47532.1 - 1 8.5 10.4 0.45 9.7 4.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Atg14 PF10186.4 EWC47532.1 - 1.3 7.9 9.0 2.3 7.0 6.2 1.3 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DnaG_DnaB_bind PF08278.6 EWC47532.1 - 2.3 8.4 8.4 36 4.5 5.8 2.2 1 1 0 1 1 1 0 DNA primase DnaG DnaB-binding Macoilin PF09726.4 EWC47532.1 - 2.6 6.1 11.3 0.32 9.2 5.0 1.4 2 0 0 2 2 2 0 Transmembrane protein Tyrosinase PF00264.15 EWC47533.1 - 2.1e-52 178.5 0.3 3.3e-52 177.8 0.2 1.3 1 0 0 1 1 1 1 Common central domain of tyrosinase AA_permease_2 PF13520.1 EWC47535.1 - 2.2e-43 148.4 21.2 2.6e-43 148.1 14.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EWC47535.1 - 3.8e-18 65.0 24.3 4.6e-18 64.8 16.8 1.0 1 0 0 1 1 1 1 Amino acid permease tRNA-synt_1b PF00579.20 EWC47536.1 - 4.2e-42 144.2 0.0 8.9e-42 143.1 0.0 1.5 1 1 0 1 1 1 1 tRNA synthetases class I (W and Y) Acetyltransf_1 PF00583.19 EWC47536.1 - 1.2e-05 25.2 0.0 3.8e-05 23.6 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_3 PF13302.1 EWC47536.1 - 4.5e-05 23.6 0.0 8.1e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 EWC47536.1 - 0.12 12.2 0.0 0.25 11.2 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain 2OG-FeII_Oxy PF03171.15 EWC47537.1 - 1.3e-10 41.3 0.0 2.6e-10 40.4 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.1 EWC47537.1 - 3.8e-07 30.6 0.0 6e-07 30.0 0.0 1.5 1 1 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal Haem_oxygenas_2 PF14518.1 EWC47538.1 - 2.3e-13 50.2 0.1 7.9e-13 48.4 0.0 2.0 2 0 0 2 2 2 1 Iron-containing redox enzyme HMGL-like PF00682.14 EWC47539.1 - 2.7e-42 145.0 0.0 3.4e-42 144.7 0.0 1.1 1 0 0 1 1 1 1 HMGL-like Diphthamide_syn PF01866.12 EWC47540.1 - 7.8e-112 373.4 0.0 9.9e-112 373.1 0.0 1.1 1 0 0 1 1 1 1 Putative diphthamide synthesis protein TerD PF02342.13 EWC47541.1 - 4.3e-13 48.9 0.1 6.9e-13 48.3 0.0 1.3 1 0 0 1 1 1 1 TerD domain UQ_con PF00179.21 EWC47541.1 - 2.7e-11 43.0 0.0 4.8e-11 42.2 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme F-box-like PF12937.2 EWC47541.1 - 9e-06 25.3 0.0 2.3e-05 24.0 0.0 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EWC47541.1 - 0.001 18.6 0.1 0.0052 16.4 0.0 2.3 2 0 0 2 2 2 1 F-box domain MFS_1 PF07690.11 EWC47542.1 - 2.8e-37 128.2 60.6 2.8e-37 128.2 42.0 3.2 2 1 0 2 2 2 1 Major Facilitator Superfamily TPR_12 PF13424.1 EWC47543.1 - 2.8e-23 81.6 13.1 4.6e-09 36.0 0.1 5.5 2 1 3 6 6 6 5 Tetratricopeptide repeat NB-ARC PF00931.17 EWC47543.1 - 8.3e-20 70.7 0.0 1.4e-19 70.0 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain TPR_10 PF13374.1 EWC47543.1 - 6.8e-14 51.2 12.5 0.0038 17.1 0.3 5.8 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_11 PF13414.1 EWC47543.1 - 3.4e-08 33.0 8.9 0.022 14.4 0.0 5.4 3 2 1 4 4 4 3 TPR repeat TPR_2 PF07719.12 EWC47543.1 - 6e-07 28.9 13.4 0.031 14.1 0.6 6.7 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_1 PF00515.23 EWC47543.1 - 2.2e-06 27.0 4.1 5.6 6.7 0.2 6.6 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_14 PF13428.1 EWC47543.1 - 5.8e-06 26.4 13.2 0.26 12.0 0.1 6.4 6 0 0 6 6 5 2 Tetratricopeptide repeat Arch_ATPase PF01637.13 EWC47543.1 - 1.2e-05 25.1 0.0 0.00013 21.7 0.0 2.3 2 0 0 2 2 2 1 Archaeal ATPase Apc3 PF12895.2 EWC47543.1 - 1.4e-05 25.1 1.8 0.17 12.0 0.0 3.9 3 1 1 4 4 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.1 EWC47543.1 - 1.7e-05 24.2 12.3 0.46 10.3 0.1 5.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.1 EWC47543.1 - 2.1e-05 23.9 8.5 2.8 7.9 0.0 5.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.1 EWC47543.1 - 7.6e-05 22.9 9.0 0.094 13.0 0.0 5.9 6 1 1 7 7 5 1 Tetratricopeptide repeat TPR_17 PF13431.1 EWC47543.1 - 0.0001 22.2 3.4 11 6.5 0.0 6.0 6 0 0 6 6 5 0 Tetratricopeptide repeat AAA_16 PF13191.1 EWC47543.1 - 0.00075 19.5 0.0 0.0079 16.2 0.0 2.8 3 1 1 4 4 4 1 AAA ATPase domain Cas_Cas02710 PF09670.5 EWC47543.1 - 0.0013 17.4 1.7 0.13 10.8 1.2 2.4 1 1 0 1 1 1 1 CRISPR-associated protein (Cas_Cas02710) PPR PF01535.15 EWC47543.1 - 0.0032 17.3 2.9 3.3 7.8 0.0 4.7 5 0 0 5 5 4 1 PPR repeat AAA_22 PF13401.1 EWC47543.1 - 0.0054 16.8 0.0 0.044 13.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain TPR_4 PF07721.9 EWC47543.1 - 0.01 16.1 8.4 1.4 9.5 0.3 4.9 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_16 PF13432.1 EWC47543.1 - 0.012 16.3 4.2 4.5 8.0 0.1 4.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_3 PF07720.7 EWC47543.1 - 0.091 12.5 0.1 5.5 6.9 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat Ribosomal_L28 PF00830.14 EWC47544.1 - 3.9e-17 61.8 0.3 7.2e-17 60.9 0.2 1.4 1 0 0 1 1 1 1 Ribosomal L28 family TMEM247 PF15444.1 EWC47544.1 - 3.4 7.4 5.6 5.7 6.6 3.9 1.3 1 0 0 1 1 1 0 Transmembrane protein 247 DUF2116 PF09889.4 EWC47545.1 - 0.088 12.6 0.7 0.36 10.6 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) Baculo_PEP_C PF04513.7 EWC47545.1 - 2.5 7.9 7.5 13 5.6 0.1 3.5 3 1 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus PAPA-1 PF04795.7 EWC47547.1 - 2.7e-26 92.0 4.1 2.7e-26 92.0 2.8 3.4 3 1 0 3 3 3 1 PAPA-1-like conserved region Rgp1 PF08737.5 EWC47548.1 - 2.7e-104 349.5 0.0 4.9e-104 348.6 0.0 1.4 1 0 0 1 1 1 1 Rgp1 Arrestin_C PF02752.17 EWC47548.1 - 0.0011 19.0 0.0 0.49 10.4 0.0 3.2 3 0 0 3 3 3 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.24 EWC47548.1 - 0.032 14.0 0.1 0.073 12.8 0.1 1.6 1 0 0 1 1 1 0 Arrestin (or S-antigen), N-terminal domain TPPII_N PF12583.3 EWC47548.1 - 0.76 9.9 4.0 1.9 8.6 2.8 1.6 1 0 0 1 1 1 0 Tripeptidyl peptidase II N terminal RFC1 PF08519.7 EWC47549.1 - 5.1e-52 175.7 0.0 2.3e-51 173.6 0.0 2.0 2 0 0 2 2 2 1 Replication factor RFC1 C terminal domain BRCT PF00533.21 EWC47549.1 - 8.7e-13 48.2 0.0 2.5e-12 46.7 0.0 1.8 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain AAA PF00004.24 EWC47549.1 - 9.9e-11 41.9 0.0 5.2e-10 39.6 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.10 EWC47549.1 - 5.3e-07 28.6 0.3 1.3e-06 27.3 0.0 1.7 2 0 0 2 2 2 1 Rad17 cell cycle checkpoint protein AAA_17 PF13207.1 EWC47549.1 - 7.9e-07 29.9 1.7 7.3e-06 26.8 0.0 3.2 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 EWC47549.1 - 1e-05 25.6 0.0 2.5e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 EWC47549.1 - 0.00065 19.5 0.0 0.0015 18.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 EWC47549.1 - 0.00072 19.8 0.0 0.00072 19.8 0.0 2.8 3 0 0 3 3 1 1 AAA domain AAA_14 PF13173.1 EWC47549.1 - 0.0011 18.8 0.0 0.0054 16.6 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 EWC47549.1 - 0.0012 18.5 0.0 0.0028 17.3 0.0 1.6 1 0 0 1 1 1 1 Part of AAA domain AAA_16 PF13191.1 EWC47549.1 - 0.0024 17.8 0.0 0.014 15.4 0.0 2.2 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.7 EWC47549.1 - 0.011 14.8 0.0 0.02 13.9 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus PTCB-BRCT PF12738.2 EWC47549.1 - 0.013 15.3 0.0 0.032 14.0 0.0 1.7 1 0 0 1 1 1 0 twin BRCT domain AAA_28 PF13521.1 EWC47549.1 - 0.017 15.0 0.0 0.049 13.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.22 EWC47549.1 - 0.03 14.6 0.2 6.1 7.1 0.0 2.9 2 0 0 2 2 2 0 ABC transporter DNA_pol3_delta PF06144.8 EWC47549.1 - 0.045 13.2 0.0 0.27 10.7 0.0 2.2 2 0 0 2 2 2 0 DNA polymerase III, delta subunit NACHT PF05729.7 EWC47549.1 - 0.051 13.2 0.0 1.1 8.9 0.0 2.4 2 0 0 2 2 2 0 NACHT domain RNA_helicase PF00910.17 EWC47549.1 - 0.08 13.1 0.0 0.08 13.1 0.0 2.3 2 1 0 2 2 1 0 RNA helicase Sigma54_activat PF00158.21 EWC47549.1 - 0.088 12.2 0.0 0.19 11.1 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_5 PF07728.9 EWC47549.1 - 0.1 12.3 0.0 0.36 10.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) NTPase_1 PF03266.10 EWC47549.1 - 0.16 11.6 0.3 0.41 10.3 0.0 1.8 2 0 0 2 2 2 0 NTPase BLOC1_2 PF10046.4 EWC47550.1 - 2.2e-07 30.9 0.0 2.8e-07 30.5 0.0 1.1 1 0 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 GrpE PF01025.14 EWC47551.1 - 5.2e-48 162.7 1.3 6.7e-48 162.3 0.9 1.1 1 0 0 1 1 1 1 GrpE ATG16 PF08614.6 EWC47551.1 - 0.0061 16.4 0.3 0.0076 16.0 0.2 1.1 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) DUF3597 PF12200.3 EWC47551.1 - 0.052 13.9 5.2 0.11 12.9 2.5 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3597) TALPID3 PF15324.1 EWC47551.1 - 0.099 9.9 4.4 0.11 9.7 3.1 1.1 1 0 0 1 1 1 0 Hedgehog signalling target tRNA-synt_2d PF01409.15 EWC47552.1 - 6.4e-51 172.9 0.1 4.1e-26 91.6 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) FDX-ACB PF03147.9 EWC47552.1 - 1.1e-24 86.4 0.0 2.3e-24 85.3 0.0 1.6 1 0 0 1 1 1 1 Ferredoxin-fold anticodon binding domain DUF2563 PF10817.3 EWC47552.1 - 0.091 13.2 0.2 0.27 11.6 0.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2563) KH_1 PF00013.24 EWC47553.1 - 4.8e-44 147.8 13.2 2.9e-16 58.8 1.4 3.3 3 0 0 3 3 3 3 KH domain KH_3 PF13014.1 EWC47553.1 - 4.1e-29 99.7 14.3 7.6e-10 38.2 1.2 3.7 3 0 0 3 3 3 3 KH domain KH_2 PF07650.12 EWC47553.1 - 1.1e-11 44.0 7.6 0.0037 16.7 0.5 3.4 3 0 0 3 3 3 3 KH domain KH_4 PF13083.1 EWC47553.1 - 2e-09 36.9 11.8 0.0023 17.5 0.0 3.9 4 0 0 4 4 4 3 KH domain KH_5 PF13184.1 EWC47553.1 - 1.2e-05 25.0 4.4 0.06 13.1 0.1 3.4 3 0 0 3 3 3 2 NusA-like KH domain GRP PF07172.6 EWC47553.1 - 0.005 17.2 53.8 0.35 11.3 5.5 2.9 2 0 0 2 2 2 2 Glycine rich protein family zf-MYND PF01753.13 EWC47555.1 - 0.18 11.7 11.0 0.33 10.8 7.6 1.4 1 0 0 1 1 1 0 MYND finger Unstab_antitox PF09720.5 EWC47556.1 - 0.021 14.4 0.1 0.038 13.6 0.0 1.4 1 0 0 1 1 1 0 Putative addiction module component WD40 PF00400.27 EWC47557.1 - 3.9e-28 96.2 16.4 3.3e-06 26.7 0.0 9.7 10 0 0 10 10 10 7 WD domain, G-beta repeat NUC173 PF08161.7 EWC47558.1 - 8e-72 240.7 0.1 1.2e-66 223.8 0.0 3.4 3 0 0 3 3 3 2 NUC173 domain HEAT PF02985.17 EWC47558.1 - 0.0027 17.6 1.9 6.5 7.1 0.0 4.8 5 0 0 5 5 5 2 HEAT repeat HEAT_2 PF13646.1 EWC47558.1 - 0.031 14.5 1.8 17 5.7 0.0 5.2 5 1 1 6 6 6 0 HEAT repeats HEAT_EZ PF13513.1 EWC47558.1 - 0.26 11.8 3.1 1.1e+02 3.4 0.0 4.8 5 0 0 5 5 5 0 HEAT-like repeat PGA2 PF07543.7 EWC47558.1 - 8.6 6.1 13.9 0.99 9.1 5.5 2.3 2 0 0 2 2 2 0 Protein trafficking PGA2 Peptidase_S8 PF00082.17 EWC47559.1 - 0.011 14.8 0.1 0.022 13.8 0.0 1.5 2 0 0 2 2 2 0 Subtilase family Mito_carr PF00153.22 EWC47560.1 - 2.5e-62 206.6 0.1 1.5e-23 82.2 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Aldo_ket_red PF00248.16 EWC47561.1 - 3.7e-24 85.0 0.0 5e-24 84.5 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family MFS_1 PF07690.11 EWC47562.1 - 4.5e-18 65.0 38.8 9.7e-12 44.2 16.4 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EWC47562.1 - 1.2e-15 57.0 19.7 2.6e-13 49.3 13.6 2.9 1 1 0 1 1 1 1 Sugar (and other) transporter PAP2 PF01569.16 EWC47563.1 - 2e-18 66.3 1.9 5.1e-18 64.9 1.3 1.7 1 0 0 1 1 1 1 PAP2 superfamily Calcipressin PF04847.7 EWC47564.1 - 1.7e-43 148.3 0.2 2.6e-43 147.7 0.1 1.2 1 0 0 1 1 1 1 Calcipressin AAA PF00004.24 EWC47565.1 - 5.3e-39 133.4 0.0 1.2e-38 132.3 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 EWC47565.1 - 3.6e-05 23.8 0.2 0.0035 17.3 0.0 3.0 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.7 EWC47565.1 - 5.3e-05 22.3 0.0 0.00014 21.0 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus TIP49 PF06068.8 EWC47565.1 - 0.00011 21.0 0.6 0.00029 19.7 0.0 1.8 2 0 0 2 2 2 1 TIP49 C-terminus AAA_17 PF13207.1 EWC47565.1 - 0.00026 21.8 0.1 0.0012 19.6 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.1 EWC47565.1 - 0.00029 20.9 0.1 0.0048 17.0 0.1 2.5 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.1 EWC47565.1 - 0.00075 19.3 0.0 0.0022 17.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.9 EWC47565.1 - 0.0013 18.4 0.0 0.0032 17.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_28 PF13521.1 EWC47565.1 - 0.0018 18.2 0.0 0.0086 16.0 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 EWC47565.1 - 0.0023 17.6 0.5 0.0081 15.8 0.3 2.0 1 0 0 1 1 1 1 Part of AAA domain AAA_14 PF13173.1 EWC47565.1 - 0.0062 16.4 0.0 0.016 15.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.12 EWC47565.1 - 0.0073 15.7 0.0 0.014 14.7 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_18 PF13238.1 EWC47565.1 - 0.0098 16.2 0.5 0.038 14.3 0.0 2.3 3 0 0 3 3 2 1 AAA domain AAA_10 PF12846.2 EWC47565.1 - 0.0098 15.3 0.4 0.46 9.8 0.0 2.5 2 0 0 2 2 2 1 AAA-like domain Mg_chelatase PF01078.16 EWC47565.1 - 0.023 13.8 0.1 0.059 12.5 0.0 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.17 EWC47565.1 - 0.03 14.5 0.0 0.063 13.4 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_24 PF13479.1 EWC47565.1 - 0.04 13.5 0.4 0.087 12.3 0.3 1.5 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.1 EWC47565.1 - 0.056 12.8 0.4 0.8 9.0 0.2 2.4 1 1 1 2 2 2 0 AAA domain Sigma54_activ_2 PF14532.1 EWC47565.1 - 0.06 13.3 0.0 0.14 12.2 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain SHQ1 PF04925.10 EWC47565.1 - 0.13 11.6 0.0 0.23 10.8 0.0 1.3 1 0 0 1 1 1 0 SHQ1 protein IPT PF01745.11 EWC47565.1 - 0.16 11.0 0.0 0.3 10.2 0.0 1.3 1 0 0 1 1 1 0 Isopentenyl transferase Parvo_NS1 PF01057.12 EWC47565.1 - 0.18 10.6 0.0 0.39 9.5 0.0 1.5 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Arch_ATPase PF01637.13 EWC47565.1 - 0.2 11.3 0.1 1.9 8.1 0.0 2.4 1 1 0 1 1 1 0 Archaeal ATPase PhoH PF02562.11 EWC47565.1 - 0.21 10.7 0.3 0.54 9.4 0.2 1.6 1 0 0 1 1 1 0 PhoH-like protein PP_M1 PF03012.9 EWC47565.1 - 0.28 10.4 0.7 18 4.5 0.0 2.7 3 0 0 3 3 3 0 Phosphoprotein Glyco_transf_34 PF05637.7 EWC47566.1 - 1.3e-46 159.0 0.0 5e-46 157.1 0.0 1.9 1 1 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family HMGL-like PF00682.14 EWC47567.1 - 2.9e-71 239.9 0.4 4.2e-71 239.3 0.3 1.2 1 0 0 1 1 1 1 HMGL-like WD40 PF00400.27 EWC47568.1 - 5.5e-30 102.1 7.7 2.3e-07 30.4 0.0 7.0 7 0 0 7 7 7 5 WD domain, G-beta repeat LisH PF08513.6 EWC47568.1 - 8.6e-08 31.6 0.0 2.6e-07 30.1 0.0 1.9 1 0 0 1 1 1 1 LisH eIF2A PF08662.6 EWC47568.1 - 0.019 14.7 0.1 0.97 9.1 0.0 3.2 2 2 1 3 3 3 0 Eukaryotic translation initiation factor eIF2A Vps16_N PF04841.8 EWC47568.1 - 0.038 12.5 0.0 0.17 10.3 0.0 1.8 1 1 1 2 2 2 0 Vps16, N-terminal region IKI3 PF04762.7 EWC47568.1 - 0.078 10.7 1.2 0.41 8.3 0.2 2.1 2 0 0 2 2 2 0 IKI3 family Nup160 PF11715.3 EWC47568.1 - 0.084 10.9 1.9 1.3 7.1 0.0 2.8 2 1 1 3 3 3 0 Nucleoporin Nup120/160 CtaG_Cox11 PF04442.9 EWC47569.1 - 3.2e-57 192.6 0.1 4e-57 192.2 0.1 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein CtaG/Cox11 zf-HIT PF04438.11 EWC47570.1 - 2.9e-09 36.3 12.2 5.6e-09 35.4 8.5 1.4 1 0 0 1 1 1 1 HIT zinc finger zf-B_box PF00643.19 EWC47570.1 - 0.015 15.1 7.3 0.025 14.4 5.1 1.3 1 0 0 1 1 1 0 B-box zinc finger zf-MYND PF01753.13 EWC47570.1 - 0.024 14.4 12.1 0.039 13.8 8.4 1.3 1 0 0 1 1 1 0 MYND finger COX6B PF02297.12 EWC47572.1 - 5.5e-19 67.9 5.5 6.4e-19 67.7 3.8 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb APOBEC_C PF05240.9 EWC47572.1 - 0.00054 19.3 1.2 0.00088 18.6 0.9 1.4 1 0 0 1 1 1 1 APOBEC-like C-terminal domain CHCH PF06747.8 EWC47572.1 - 0.031 14.1 1.2 0.079 12.9 0.8 1.7 1 1 0 1 1 1 0 CHCH domain UCR_hinge PF02320.11 EWC47572.1 - 0.044 13.7 0.5 0.066 13.1 0.0 1.7 2 0 0 2 2 2 0 Ubiquinol-cytochrome C reductase hinge protein UPF0203 PF05254.7 EWC47572.1 - 0.17 11.7 6.4 0.94 9.3 1.3 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0203) DUF1741 PF08427.5 EWC47573.1 - 4.6e-68 229.2 0.0 5.3e-68 229.0 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1741) Rep_fac_C PF08542.6 EWC47575.1 - 1.1e-23 82.9 0.0 3.1e-23 81.5 0.0 1.8 1 0 0 1 1 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.1 EWC47575.1 - 1.3e-10 41.2 0.1 2.3e-10 40.3 0.1 1.5 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA_22 PF13401.1 EWC47575.1 - 8.8e-06 25.8 0.6 0.00012 22.2 0.3 2.4 1 1 1 2 2 2 1 AAA domain AAA PF00004.24 EWC47575.1 - 1e-05 25.7 0.2 2.2e-05 24.6 0.1 1.5 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 EWC47575.1 - 4e-05 23.6 2.8 0.037 14.0 0.0 3.1 2 1 0 3 3 3 1 AAA ATPase domain Sigma54_activ_2 PF14532.1 EWC47575.1 - 0.00023 21.2 0.2 0.021 14.8 0.2 2.4 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_33 PF13671.1 EWC47575.1 - 0.012 15.5 0.1 0.02 14.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain Resolvase PF00239.16 EWC47575.1 - 0.022 14.6 0.1 2.9 7.7 0.1 2.3 2 0 0 2 2 2 0 Resolvase, N terminal domain T4SS-DNA_transf PF02534.9 EWC47575.1 - 0.024 13.2 0.0 0.043 12.3 0.0 1.3 1 0 0 1 1 1 0 Type IV secretory system Conjugative DNA transfer Rad17 PF03215.10 EWC47575.1 - 0.025 13.2 0.0 0.03 13.0 0.0 1.1 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein SNF2_N PF00176.18 EWC47575.1 - 0.054 12.2 0.0 0.061 12.1 0.0 1.2 1 0 0 1 1 1 0 SNF2 family N-terminal domain ABC_tran PF00005.22 EWC47575.1 - 0.084 13.1 0.1 0.19 12.0 0.1 1.5 1 1 0 1 1 1 0 ABC transporter AAA_10 PF12846.2 EWC47575.1 - 0.09 12.1 0.1 1.3 8.4 0.0 2.2 1 1 0 2 2 2 0 AAA-like domain AAA_5 PF07728.9 EWC47575.1 - 0.11 12.2 0.5 0.36 10.5 0.3 1.9 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) LIM_bind PF01803.11 EWC47576.1 - 3.5e-65 219.4 0.1 3.5e-65 219.4 0.1 5.1 3 1 1 4 4 4 1 LIM-domain binding protein Peptidase_S46 PF10459.4 EWC47576.1 - 0.21 9.9 40.2 0.0057 15.1 21.9 2.0 2 0 0 2 2 2 0 Peptidase S46 cobW PF02492.14 EWC47577.1 - 1.6e-34 118.8 0.0 1.9e-34 118.6 0.0 1.1 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain ArgK PF03308.11 EWC47577.1 - 0.00084 18.2 0.1 0.12 11.1 0.0 2.2 2 0 0 2 2 2 2 ArgK protein MMR_HSR1 PF01926.18 EWC47577.1 - 0.0055 16.6 0.0 0.015 15.2 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_17 PF13207.1 EWC47577.1 - 0.044 14.6 0.1 0.077 13.8 0.1 1.4 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.1 EWC47577.1 - 0.06 13.6 0.0 0.11 12.8 0.0 1.5 1 1 0 1 1 1 0 AAA domain TMEM51 PF15345.1 EWC47577.1 - 0.11 12.1 0.0 0.16 11.6 0.0 1.2 1 0 0 1 1 1 0 Transmembrane protein 51 Pox_A32 PF04665.7 EWC47577.1 - 0.12 11.6 0.0 0.17 11.1 0.0 1.2 1 0 0 1 1 1 0 Poxvirus A32 protein AAA_22 PF13401.1 EWC47577.1 - 0.12 12.5 0.0 0.39 10.8 0.0 1.9 2 1 0 2 2 2 0 AAA domain TIP49 PF06068.8 EWC47577.1 - 0.13 10.9 0.0 0.19 10.3 0.0 1.1 1 0 0 1 1 1 0 TIP49 C-terminus ResIII PF04851.10 EWC47577.1 - 0.14 11.9 0.0 0.17 11.6 0.0 1.2 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit NUDIX PF00293.23 EWC47578.1 - 1.3e-16 60.4 0.1 1.6e-16 60.1 0.1 1.1 1 0 0 1 1 1 1 NUDIX domain AMP-binding PF00501.23 EWC47579.1 - 4.3e-72 242.8 0.0 7e-72 242.1 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.7 EWC47579.1 - 1.5e-71 240.2 0.0 2.3e-71 239.6 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein PP-binding PF00550.20 EWC47579.1 - 5.2e-13 49.0 0.0 1.1e-12 47.9 0.0 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site Epimerase PF01370.16 EWC47579.1 - 9.5e-12 44.8 0.0 5.4e-11 42.3 0.0 2.1 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family AMP-binding_C PF13193.1 EWC47579.1 - 1.7e-09 38.4 0.0 6.1e-09 36.7 0.0 2.1 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain 3Beta_HSD PF01073.14 EWC47579.1 - 0.0027 16.4 0.0 0.0092 14.7 0.0 1.8 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.1 EWC47579.1 - 0.0071 16.3 0.0 0.21 11.5 0.0 2.5 1 1 0 1 1 1 1 NADH(P)-binding Chorismate_bind PF00425.13 EWC47580.1 - 1.5e-92 309.5 0.0 2.3e-92 308.9 0.0 1.3 1 0 0 1 1 1 1 chorismate binding enzyme Anth_synt_I_N PF04715.8 EWC47580.1 - 1.9e-33 115.3 0.7 3e-28 98.5 0.0 3.3 2 1 0 2 2 2 2 Anthranilate synthase component I, N terminal region Ribosomal_L16 PF00252.13 EWC47581.1 - 4.4e-31 107.3 0.4 4.4e-31 107.3 0.3 1.4 2 0 0 2 2 2 1 Ribosomal protein L16p/L10e ATE_C PF04377.10 EWC47582.1 - 4.5e-42 143.1 2.0 7.6e-42 142.4 1.4 1.4 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, C terminus ATE_N PF04376.8 EWC47582.1 - 7.1e-20 70.6 1.3 2.2e-19 69.0 0.3 2.3 2 0 0 2 2 2 1 Arginine-tRNA-protein transferase, N terminus Fer2 PF00111.22 EWC47582.1 - 0.022 14.5 0.0 0.047 13.4 0.0 1.5 1 0 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain Acetyltransf_6 PF13480.1 EWC47582.1 - 0.27 11.2 1.5 0.58 10.1 1.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain WD40 PF00400.27 EWC47585.1 - 4.8e-17 61.1 0.6 0.0029 17.4 0.1 5.8 4 1 1 5 5 5 4 WD domain, G-beta repeat Sec16_C PF12931.2 EWC47585.1 - 0.00017 21.4 0.4 0.00041 20.1 0.3 1.6 1 1 0 1 1 1 1 Sec23-binding domain of Sec16 TPR_19 PF14559.1 EWC47585.1 - 0.059 13.7 0.5 0.24 11.7 0.4 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat SOG2 PF10428.4 EWC47585.1 - 5.5 5.5 6.9 8.4 4.9 4.8 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein HLH PF00010.21 EWC47587.1 - 7.6e-08 31.9 0.0 1.5e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF4551 PF15087.1 EWC47587.1 - 2.8 6.1 4.8 3.8 5.7 3.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) GET2 PF08690.5 EWC47588.1 - 0.00061 19.1 5.7 0.00061 19.1 4.0 2.5 2 1 0 2 2 2 1 GET complex subunit GET2 CCDC84 PF14968.1 EWC47588.1 - 0.041 13.3 0.3 0.056 12.9 0.2 1.2 1 0 0 1 1 1 0 Coiled coil protein 84 L51_S25_CI-B8 PF05047.11 EWC47589.1 - 3.9e-11 42.5 0.0 8.1e-11 41.4 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain CENP-Q PF13094.1 EWC47590.1 - 3.6e-19 69.3 7.4 7.1e-19 68.3 5.2 1.5 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit Peptidase_S49 PF01343.13 EWC47590.1 - 0.024 14.4 0.4 0.064 13.0 0.1 1.9 1 1 1 2 2 2 0 Peptidase family S49 Menin PF05053.8 EWC47591.1 - 1 7.4 10.1 1.2 7.2 7.0 1.1 1 0 0 1 1 1 0 Menin DUF605 PF04652.11 EWC47591.1 - 2 7.7 10.9 2.2 7.5 7.6 1.0 1 0 0 1 1 1 0 Vta1 like PAS PF00989.19 EWC47592.1 - 0.095 12.4 0.0 0.21 11.3 0.0 1.6 1 0 0 1 1 1 0 PAS fold YvrJ PF12841.2 EWC47593.1 - 0.018 14.2 0.4 2.4 7.5 0.2 2.2 2 0 0 2 2 2 0 YvrJ protein family Sec6 PF06046.8 EWC47594.1 - 8e-129 430.2 0.5 1.2e-128 429.7 0.4 1.2 1 0 0 1 1 1 1 Exocyst complex component Sec6 Vps53_N PF04100.7 EWC47594.1 - 0.0094 14.7 0.9 0.0094 14.7 0.6 1.6 2 0 0 2 2 2 1 Vps53-like, N-terminal DASH_Spc34 PF08657.5 EWC47594.1 - 0.06 13.0 0.6 0.14 11.7 0.1 1.8 2 0 0 2 2 2 0 DASH complex subunit Spc34 DUF2450 PF10475.4 EWC47594.1 - 0.074 11.9 1.7 0.17 10.7 1.2 1.5 1 0 0 1 1 1 0 Protein of unknown function N-terminal domain (DUF2450) DUF3829 PF12889.2 EWC47594.1 - 1.7 7.7 5.5 0.83 8.7 1.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3829) NPV_P10 PF05531.7 EWC47594.1 - 2.1 8.6 10.1 15 5.9 4.5 3.3 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Ribosomal_L30 PF00327.15 EWC47595.1 - 8e-17 60.5 0.3 1.1e-16 60.1 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e DUF969 PF06149.7 EWC47595.1 - 0.043 13.0 0.1 0.047 12.9 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF969) Pyridoxal_deC PF00282.14 EWC47596.1 - 6.3e-23 80.8 0.0 9.1e-23 80.2 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.14 EWC47596.1 - 5.3e-10 38.5 0.0 9.4e-10 37.7 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.12 EWC47596.1 - 6.9e-05 22.0 0.0 0.00011 21.4 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Asp PF00026.18 EWC47597.1 - 7.9e-09 35.1 2.1 6.1e-06 25.6 1.4 2.3 1 1 0 1 1 1 1 Eukaryotic aspartyl protease RVP PF00077.15 EWC47597.1 - 0.051 13.4 0.7 0.23 11.4 0.0 2.2 1 1 1 2 2 2 0 Retroviral aspartyl protease DUF4050 PF13259.1 EWC47598.1 - 1.4e-28 99.2 0.1 1.4e-28 99.2 0.1 2.2 2 1 0 2 2 2 1 Protein of unknown function (DUF4050) Nucleo_P87 PF07267.6 EWC47598.1 - 0.52 8.9 7.2 0.81 8.3 5.0 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 CDC45 PF02724.9 EWC47598.1 - 8.2 4.3 12.9 11 3.8 9.0 1.1 1 0 0 1 1 1 0 CDC45-like protein FAM176 PF14851.1 EWC47598.1 - 9.9 5.8 6.7 24 4.5 4.6 1.6 1 0 0 1 1 1 0 FAM176 family SNAP PF14938.1 EWC47599.1 - 3.2e-86 288.9 15.9 3.6e-86 288.8 11.0 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_6 PF13174.1 EWC47599.1 - 0.00041 20.6 7.0 51 4.6 0.1 5.8 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_12 PF13424.1 EWC47599.1 - 0.0036 17.1 10.0 0.051 13.5 0.4 3.3 1 1 2 3 3 3 2 Tetratricopeptide repeat MIT PF04212.13 EWC47599.1 - 0.03 14.1 9.8 1.5 8.7 0.3 3.7 2 1 1 3 3 3 0 MIT (microtubule interacting and transport) domain TPR_14 PF13428.1 EWC47599.1 - 0.069 13.8 11.2 17 6.4 0.0 5.2 3 2 2 5 5 5 0 Tetratricopeptide repeat Spatacsin_C PF14649.1 EWC47599.1 - 0.7 8.7 5.1 4.7 5.9 1.2 2.4 1 1 1 2 2 2 0 Spatacsin C-terminus TPR_8 PF13181.1 EWC47599.1 - 1.1 9.2 11.5 2.4 8.1 0.0 5.4 4 2 1 6 6 6 0 Tetratricopeptide repeat TPR_16 PF13432.1 EWC47599.1 - 1.4 9.6 15.9 0.12 13.0 1.5 3.9 3 2 1 4 4 4 0 Tetratricopeptide repeat Glu-tRNAGln PF02686.10 EWC47600.1 - 0.003 17.3 0.1 0.0072 16.1 0.1 1.8 1 1 0 1 1 1 1 Glu-tRNAGln amidotransferase C subunit Tetraspannin PF00335.15 EWC47601.1 - 0.026 13.7 0.0 0.039 13.2 0.0 1.4 1 1 0 1 1 1 0 Tetraspanin family Cytochrom_C PF00034.16 EWC47602.1 - 1.8e-10 41.4 0.2 4e-10 40.3 0.1 1.5 1 1 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.1 EWC47602.1 - 1.6e-09 37.7 0.8 3.1e-08 33.6 0.5 2.0 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.1 EWC47602.1 - 0.0026 17.2 0.7 0.024 14.1 0.1 2.2 2 1 0 2 2 2 1 Cytochrome c-550 domain UPF0128 PF03673.8 EWC47602.1 - 0.043 13.0 0.0 0.049 12.9 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0128) Docking PF08990.6 EWC47602.1 - 0.22 10.7 2.6 2.5 7.4 0.5 2.2 2 0 0 2 2 2 0 Erythronolide synthase docking PAT1 PF09770.4 EWC47603.1 - 5.4 5.1 10.1 5.7 5.0 7.0 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 zf-Tim10_DDP PF02953.10 EWC47604.1 - 4.9e-23 80.1 0.6 5.8e-23 79.9 0.4 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger DUF3398 PF11878.3 EWC47604.1 - 0.015 15.1 0.0 0.02 14.7 0.0 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF3398) Cyclin_N PF00134.18 EWC47605.1 - 9.2e-06 25.2 0.1 3.8e-05 23.2 0.1 2.0 1 1 0 1 1 1 1 Cyclin, N-terminal domain VQ PF05678.9 EWC47605.1 - 0.015 14.3 1.1 0.64 9.1 0.0 2.6 2 0 0 2 2 2 0 VQ motif ADH_N PF08240.7 EWC47606.1 - 2.8e-34 117.1 1.6 1.3e-33 115.0 1.5 1.8 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 EWC47606.1 - 1.2e-15 57.2 0.0 1.9e-15 56.5 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 EWC47606.1 - 0.0031 18.4 0.0 0.0061 17.4 0.0 1.5 1 1 0 1 1 1 1 Zinc-binding dehydrogenase FAD_binding_3 PF01494.14 EWC47606.1 - 0.0077 15.3 0.4 0.013 14.5 0.3 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_7 PF13241.1 EWC47606.1 - 0.013 15.7 0.0 0.029 14.6 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding DUF2318 PF10080.4 EWC47606.1 - 0.045 13.5 0.9 14 5.5 0.5 3.0 3 0 0 3 3 3 0 Predicted membrane protein (DUF2318) RCC1 PF00415.13 EWC47607.1 - 4.9e-05 23.4 11.7 0.014 15.5 0.1 5.0 5 1 0 5 5 5 2 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 EWC47607.1 - 0.044 13.4 14.2 0.096 12.3 0.1 5.0 5 0 0 5 5 5 0 Regulator of chromosome condensation (RCC1) repeat RasGEF PF00617.14 EWC47609.1 - 5.5e-44 150.1 0.1 2.3e-43 148.1 0.1 1.9 2 0 0 2 2 2 1 RasGEF domain Miro PF08477.8 EWC47609.1 - 1.5e-10 41.5 0.0 4e-10 40.2 0.0 1.7 1 0 0 1 1 1 1 Miro-like protein Ras PF00071.17 EWC47609.1 - 1.4e-07 31.0 0.1 1.2e-06 27.9 0.1 2.2 1 1 0 1 1 1 1 Ras family RasGEF_N PF00618.15 EWC47609.1 - 1.8e-05 24.7 0.0 6.4e-05 23.0 0.0 1.9 2 0 0 2 2 2 1 RasGEF N-terminal motif Arf PF00025.16 EWC47609.1 - 0.0025 17.1 0.0 0.0059 15.8 0.0 1.5 1 1 0 1 1 1 1 ADP-ribosylation factor family FeoB_N PF02421.13 EWC47609.1 - 0.076 12.2 0.0 1.3 8.2 0.0 2.2 2 0 0 2 2 2 0 Ferrous iron transport protein B MMR_HSR1 PF01926.18 EWC47609.1 - 0.082 12.8 0.1 0.33 10.9 0.1 2.0 1 1 0 1 1 1 0 50S ribosome-binding GTPase PSP1 PF04468.7 EWC47610.1 - 3.5e-30 103.8 1.9 6.1e-30 103.0 1.3 1.4 1 0 0 1 1 1 1 PSP1 C-terminal conserved region Ribosomal_L15e PF00827.12 EWC47612.1 - 6.2e-89 296.6 12.7 9.9e-89 295.9 8.8 1.3 1 0 0 1 1 1 1 Ribosomal L15 HECT PF00632.20 EWC47614.1 - 3.4e-74 249.8 0.0 5.4e-74 249.1 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Nfu_N PF08712.6 EWC47615.1 - 5.1e-31 106.1 0.0 1.7e-30 104.4 0.0 1.8 2 0 0 2 2 2 1 Scaffold protein Nfu/NifU N terminal NifU PF01106.12 EWC47615.1 - 5e-21 74.2 0.1 7.6e-21 73.6 0.0 1.3 1 0 0 1 1 1 1 NifU-like domain DUF2407_C PF13373.1 EWC47616.1 - 4.7e-27 94.6 0.1 7e-27 94.0 0.1 1.3 1 0 0 1 1 1 1 DUF2407 C-terminal domain DUF2407 PF10302.4 EWC47616.1 - 5.7e-16 58.4 0.0 1e-15 57.6 0.0 1.4 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain ubiquitin PF00240.18 EWC47616.1 - 0.00029 20.1 0.0 0.00054 19.2 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family Fe-S_biosyn PF01521.15 EWC47617.1 - 2.1e-20 72.7 0.0 2.6e-20 72.4 0.0 1.1 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis Acetyltransf_9 PF13527.1 EWC47618.1 - 2.5e-06 27.3 0.0 3.2e-06 27.0 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 EWC47618.1 - 4.2e-06 26.8 0.0 5.1e-06 26.5 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 EWC47618.1 - 9.6e-06 25.5 0.0 1.3e-05 25.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_8 PF13523.1 EWC47618.1 - 0.0054 16.6 0.0 0.0068 16.2 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 EWC47618.1 - 0.0055 16.8 0.0 0.0069 16.5 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.1 EWC47618.1 - 0.0092 15.8 0.0 0.013 15.3 0.0 1.2 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Pyridoxal_deC PF00282.14 EWC47619.1 - 3.4e-08 32.3 0.0 7.6e-05 21.3 0.0 2.4 3 0 0 3 3 3 2 Pyridoxal-dependent decarboxylase conserved domain Dynactin PF12455.3 EWC47620.1 - 3.8e-72 242.4 11.2 3.8e-72 242.4 7.7 3.5 4 0 0 4 4 4 1 Dynein associated protein CAP_GLY PF01302.20 EWC47620.1 - 1.1e-19 69.9 1.4 1.8e-19 69.1 1.0 1.4 1 0 0 1 1 1 1 CAP-Gly domain F_actin_bind PF08919.5 EWC47620.1 - 0.062 13.0 15.0 0.031 13.9 0.5 4.0 4 0 0 4 4 4 0 F-actin binding IncA PF04156.9 EWC47620.1 - 0.33 10.5 92.5 0.061 12.9 7.1 5.4 2 1 3 5 5 5 0 IncA protein Reo_sigmaC PF04582.7 EWC47620.1 - 0.44 9.6 22.6 0.15 11.2 0.5 4.6 2 1 3 5 5 5 0 Reovirus sigma C capsid protein ZZ PF00569.12 EWC47622.1 - 7.1e-06 25.4 6.0 1.8e-05 24.1 4.1 1.6 1 0 0 1 1 1 1 Zinc finger, ZZ type PGAP1 PF07819.8 EWC47622.1 - 5.3e-05 22.9 0.0 8.8e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_6 PF12697.2 EWC47622.1 - 0.0036 17.2 0.1 0.011 15.6 0.0 1.9 1 0 0 1 1 1 1 Alpha/beta hydrolase family Cutinase PF01083.17 EWC47622.1 - 0.022 14.5 0.0 0.05 13.3 0.0 1.5 1 0 0 1 1 1 0 Cutinase DUF676 PF05057.9 EWC47622.1 - 0.083 12.1 0.0 0.17 11.1 0.0 1.4 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Dabb PF07876.7 EWC47623.1 - 1.3e-20 73.5 0.0 1.6e-20 73.3 0.0 1.0 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain RNA_pol_A_bac PF01000.21 EWC47624.1 - 4.3e-32 110.5 0.0 6.4e-32 110.0 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.19 EWC47624.1 - 1.7e-16 59.0 0.0 2.2e-16 58.7 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Asp PF00026.18 EWC47625.1 - 3.3e-07 29.8 0.1 2.2e-06 27.1 0.0 2.0 1 1 0 1 1 1 1 Eukaryotic aspartyl protease Methyltransf_23 PF13489.1 EWC47626.1 - 3.3e-19 69.1 0.0 6.8e-19 68.1 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EWC47626.1 - 2e-10 41.0 0.0 4.3e-10 39.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EWC47626.1 - 3.3e-09 36.4 0.0 1.4e-07 31.2 0.0 2.7 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 EWC47626.1 - 3.4e-07 30.6 0.0 6.3e-06 26.5 0.0 2.9 3 1 0 3 3 3 1 Methyltransferase domain Methyltransf_18 PF12847.2 EWC47626.1 - 6.7e-07 29.8 0.0 9.1e-06 26.2 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EWC47626.1 - 0.00023 21.4 0.0 0.0011 19.2 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.13 EWC47626.1 - 0.003 16.7 0.0 0.065 12.3 0.0 2.2 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_26 PF13659.1 EWC47626.1 - 0.0048 16.9 0.0 0.032 14.2 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.14 EWC47626.1 - 0.02 14.9 0.1 0.14 12.0 0.0 2.0 1 1 1 2 2 2 0 FtsJ-like methyltransferase Methyltransf_8 PF05148.10 EWC47626.1 - 0.031 13.8 0.0 0.32 10.5 0.0 2.1 2 0 0 2 2 2 0 Hypothetical methyltransferase MTS PF05175.9 EWC47626.1 - 0.091 12.1 0.0 0.52 9.6 0.0 2.1 3 0 0 3 3 3 0 Methyltransferase small domain Halo_GVPC PF05465.8 EWC47626.1 - 4.4 7.3 5.5 0.35 10.8 0.2 2.0 2 0 0 2 2 2 0 Halobacterial gas vesicle protein C (GVPC) repeat Rxt3 PF08642.5 EWC47627.1 - 8.6e-19 67.8 0.0 2.5e-18 66.4 0.0 1.9 1 0 0 1 1 1 1 Histone deacetylation protein Rxt3 LCCL PF03815.14 EWC47627.1 - 0.19 11.7 0.0 4 7.4 0.0 2.4 2 0 0 2 2 2 0 LCCL domain NAD_binding_10 PF13460.1 EWC47628.1 - 8.9e-17 61.6 0.8 1.3e-16 61.1 0.5 1.3 1 0 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 EWC47628.1 - 9.7e-05 21.9 0.0 0.00014 21.3 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family adh_short PF00106.20 EWC47628.1 - 0.00052 19.9 0.1 0.0011 18.9 0.1 1.6 1 1 0 1 1 1 1 short chain dehydrogenase DUF726 PF05277.7 EWC47629.1 - 2.2e-97 326.0 13.0 5e-85 285.4 0.1 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF726) Abhydrolase_6 PF12697.2 EWC47629.1 - 0.0047 16.8 0.6 0.014 15.2 0.1 2.0 2 0 0 2 2 2 1 Alpha/beta hydrolase family Pro-NT_NN PF07421.6 EWC47629.1 - 0.058 12.8 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 Neurotensin/neuromedin N precursor Glyco_transf_15 PF01793.11 EWC47630.1 - 4e-138 459.8 0.2 4.9e-138 459.6 0.1 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase GCN5L1 PF06320.8 EWC47631.1 - 8.3e-17 61.1 3.9 9.9e-17 60.8 2.7 1.0 1 0 0 1 1 1 1 GCN5-like protein 1 (GCN5L1) EzrA PF06160.7 EWC47631.1 - 0.0017 16.6 0.2 0.0018 16.5 0.2 1.0 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA Syntaxin-6_N PF09177.6 EWC47631.1 - 0.0082 16.5 3.3 0.13 12.6 0.2 2.0 1 1 1 2 2 2 2 Syntaxin 6, N-terminal DUF2205 PF10224.4 EWC47631.1 - 0.013 15.0 0.4 0.021 14.4 0.3 1.4 1 0 0 1 1 1 0 Predicted coiled-coil protein (DUF2205) DUF1664 PF07889.7 EWC47631.1 - 0.029 14.1 0.9 0.28 11.0 0.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Atg14 PF10186.4 EWC47631.1 - 0.16 10.9 5.3 0.19 10.6 3.7 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF869 PF05911.6 EWC47631.1 - 0.16 10.1 4.0 0.19 9.9 2.8 1.0 1 0 0 1 1 1 0 Plant protein of unknown function (DUF869) Nup54 PF13874.1 EWC47631.1 - 0.34 10.5 3.0 0.51 10.0 2.1 1.2 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 XhlA PF10779.4 EWC47631.1 - 0.65 9.9 4.7 3.5 7.5 0.5 2.3 2 0 0 2 2 2 0 Haemolysin XhlA Gon7 PF08738.5 EWC47632.1 - 6.4e-13 48.5 0.5 6.4e-13 48.5 0.4 2.1 1 1 1 2 2 2 1 Gon7 family Cwf_Cwc_15 PF04889.7 EWC47632.1 - 0.0038 16.9 6.5 0.0043 16.8 4.5 1.1 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein HAUS6_N PF14661.1 EWC47632.1 - 0.56 9.5 5.5 0.7 9.2 3.8 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus CLN3 PF02487.12 EWC47633.1 - 5e-95 318.6 13.1 4.1e-94 315.6 9.1 2.2 1 1 0 1 1 1 1 CLN3 protein DUF3638 PF12340.3 EWC47633.1 - 4.1e-82 274.5 0.1 8.4e-82 273.5 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3638) DUF3645 PF12359.3 EWC47633.1 - 1.1e-12 46.8 0.2 4.5e-12 44.8 0.1 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF3645) PrgI PF12666.2 EWC47633.1 - 0.53 10.4 2.1 1.9 8.6 1.5 2.0 1 0 0 1 1 1 0 PrgI family protein MFS_1 PF07690.11 EWC47633.1 - 1.5 7.4 28.4 1.2 7.7 18.2 1.8 1 1 0 1 1 1 0 Major Facilitator Superfamily Vps39_2 PF10367.4 EWC47634.1 - 3.6e-33 114.0 0.0 7.3e-33 113.0 0.0 1.6 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 CNH PF00780.17 EWC47634.1 - 6.3e-32 111.0 0.0 9.5e-32 110.5 0.0 1.2 1 0 0 1 1 1 1 CNH domain Vps39_1 PF10366.4 EWC47634.1 - 2.4e-30 104.7 0.5 1.9e-29 101.8 0.0 2.7 3 0 0 3 3 3 1 Vacuolar sorting protein 39 domain 1 Clathrin PF00637.15 EWC47634.1 - 6.8e-06 25.7 1.7 0.019 14.5 0.0 3.0 3 0 0 3 3 3 2 Region in Clathrin and VPS TPR_16 PF13432.1 EWC47634.1 - 0.00058 20.4 2.0 3.5 8.4 0.6 3.6 2 2 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.1 EWC47634.1 - 0.00068 19.2 0.6 9.5 6.2 0.1 5.1 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.1 EWC47634.1 - 0.001 19.5 3.4 11 6.9 0.1 4.9 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.12 EWC47634.1 - 0.0013 18.5 0.3 29 4.9 0.0 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat Apc3 PF12895.2 EWC47634.1 - 0.0014 18.7 0.1 0.19 11.9 0.1 3.2 3 0 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.1 EWC47634.1 - 0.0033 17.0 1.0 2.6 7.7 0.0 4.3 4 1 0 4 4 4 1 TPR repeat TPR_1 PF00515.23 EWC47634.1 - 0.0043 16.6 0.1 2.4 7.8 0.0 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat Rad50_zn_hook PF04423.9 EWC47634.1 - 0.014 14.8 0.1 0.037 13.5 0.1 1.7 1 0 0 1 1 1 0 Rad50 zinc hook motif TPR_12 PF13424.1 EWC47634.1 - 0.032 14.1 5.6 4.4 7.3 0.5 3.9 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.1 EWC47634.1 - 0.047 14.0 4.4 0.85 10.0 0.6 3.2 4 0 0 4 4 2 0 Tetratricopeptide repeat TPR_10 PF13374.1 EWC47634.1 - 0.4 10.6 4.4 11 6.0 0.1 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat Na_Ca_ex PF01699.19 EWC47635.1 - 3.4e-23 81.7 15.6 4.8e-16 58.6 3.6 2.6 2 1 0 2 2 2 2 Sodium/calcium exchanger protein DUF4131 PF13567.1 EWC47635.1 - 0.73 9.2 6.4 0.62 9.4 0.1 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4131) ABC_membrane_2 PF06472.10 EWC47636.1 - 5.6e-106 353.7 1.3 8e-106 353.2 0.9 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.22 EWC47636.1 - 7e-19 68.4 0.0 1.5e-18 67.4 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 EWC47636.1 - 0.0003 20.8 0.0 0.0009 19.2 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_23 PF13476.1 EWC47636.1 - 0.004 17.4 0.6 0.019 15.3 0.4 2.1 1 1 0 1 1 1 1 AAA domain SMC_N PF02463.14 EWC47636.1 - 0.0076 15.5 0.2 0.11 11.7 0.0 2.3 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 EWC47636.1 - 0.018 14.5 0.0 0.04 13.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Pex26 PF07163.7 EWC47636.1 - 0.096 11.5 0.2 0.17 10.7 0.1 1.3 1 0 0 1 1 1 0 Pex26 protein RNA_helicase PF00910.17 EWC47636.1 - 0.12 12.5 0.0 0.32 11.2 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_16 PF13191.1 EWC47636.1 - 0.16 11.9 1.3 0.44 10.5 0.0 2.3 3 0 0 3 3 3 0 AAA ATPase domain 6PF2K PF01591.13 EWC47637.1 - 3.8e-80 268.1 0.2 5.7e-80 267.5 0.1 1.3 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.17 EWC47637.1 - 3.3e-31 108.4 0.0 6.9e-31 107.4 0.0 1.5 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.1 EWC47637.1 - 1.6e-08 34.5 0.1 2.9e-08 33.7 0.1 1.4 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.5 EWC47637.1 - 9.3e-07 28.3 0.1 1.5e-06 27.6 0.1 1.3 1 0 0 1 1 1 1 Chromatin associated protein KTI12 DUF4248 PF14053.1 EWC47637.1 - 0.048 13.2 0.0 1.7 8.2 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4248) AAA_17 PF13207.1 EWC47637.1 - 0.089 13.6 0.2 0.53 11.1 0.0 2.3 2 1 0 2 2 2 0 AAA domain DUF913 PF06025.7 EWC47638.1 - 1.4e-101 340.0 0.0 1.4e-101 340.0 0.0 4.5 5 1 0 5 5 5 1 Domain of Unknown Function (DUF913) HECT PF00632.20 EWC47638.1 - 1.8e-95 319.7 0.2 3.1e-95 318.9 0.1 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) DUF908 PF06012.7 EWC47638.1 - 5e-70 236.4 0.0 5e-70 236.4 0.0 2.7 3 0 0 3 3 3 1 Domain of Unknown Function (DUF908) DUF4414 PF14377.1 EWC47638.1 - 8.8e-32 109.2 8.6 8.8e-32 109.2 6.0 5.4 4 1 1 5 5 5 1 Domain of unknown function (DUF4414) UBA PF00627.26 EWC47638.1 - 1.3e-08 34.4 0.0 3.9e-08 32.8 0.0 1.9 1 0 0 1 1 1 1 UBA/TS-N domain NARP1 PF12569.3 EWC47638.1 - 9.1 4.8 29.8 1.1 7.9 4.6 3.0 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 RabGAP-TBC PF00566.13 EWC47639.1 - 6.5e-44 149.9 0.0 2e-43 148.3 0.0 1.8 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Ribosomal_S13 PF00416.17 EWC47639.1 - 1.4 9.4 4.6 52 4.3 0.0 3.1 2 1 0 2 2 2 0 Ribosomal protein S13/S18 APG6 PF04111.7 EWC47639.1 - 1.7 7.5 22.5 0.76 8.7 3.5 2.3 1 1 1 2 2 2 0 Autophagy protein Apg6 Atg14 PF10186.4 EWC47639.1 - 2.4 7.0 13.1 5 5.9 9.1 1.5 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF972 PF06156.8 EWC47639.1 - 3.9 7.8 23.3 7.4 6.9 4.1 3.7 1 1 2 3 3 3 0 Protein of unknown function (DUF972) PNP_UDP_1 PF01048.15 EWC47641.1 - 8.4e-09 34.7 0.2 2.1e-08 33.4 0.2 1.6 1 1 0 1 1 1 1 Phosphorylase superfamily Glyco_hydro_71 PF03659.9 EWC47642.1 - 3.7e-122 407.5 3.0 4.4e-122 407.2 2.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 71 DUF4434 PF14488.1 EWC47642.1 - 0.023 14.4 0.0 0.043 13.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4434) Mus7 PF09462.5 EWC47643.1 - 1.1e-98 331.6 9.4 1.5e-98 331.2 6.5 1.1 1 0 0 1 1 1 1 Mus7/MMS22 family Fra10Ac1 PF09725.4 EWC47643.1 - 3.9e-38 130.1 0.1 7.9e-38 129.1 0.1 1.5 1 0 0 1 1 1 1 Folate-sensitive fragile site protein Fra10Ac1 NADase_NGA PF07461.6 EWC47643.1 - 0.076 11.6 0.0 0.14 10.8 0.0 1.3 1 0 0 1 1 1 0 Nicotine adenine dinucleotide glycohydrolase (NADase) DUF1033 PF06279.6 EWC47643.1 - 0.7 9.7 2.7 0.41 10.4 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1033) Abhydrolase_3 PF07859.8 EWC47644.1 - 7.9e-38 130.1 0.0 5.2e-27 94.7 0.0 2.5 2 0 0 2 2 2 2 alpha/beta hydrolase fold DUF2424 PF10340.4 EWC47644.1 - 0.074 11.6 0.0 0.11 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2424) zf-CSL PF05207.8 EWC47646.1 - 8.2e-24 82.8 0.3 1e-23 82.5 0.2 1.1 1 0 0 1 1 1 1 CSL zinc finger PPTA PF01239.17 EWC47648.1 - 9e-34 113.4 5.9 7.8e-07 28.1 0.6 6.0 6 0 0 6 6 6 5 Protein prenyltransferase alpha subunit repeat GLTP PF08718.6 EWC47648.1 - 0.074 13.0 0.1 1.2 9.1 0.0 2.5 2 0 0 2 2 2 0 Glycolipid transfer protein (GLTP) YopR_core PF09025.5 EWC47648.1 - 0.082 12.9 0.4 7 6.6 0.0 2.3 2 0 0 2 2 2 0 YopR Core DUF3950 PF13132.1 EWC47648.1 - 0.12 11.9 0.1 0.24 10.9 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3950) Ribosomal_S6e PF01092.14 EWC47649.1 - 1.1e-62 209.3 0.4 1.9e-62 208.5 0.3 1.4 1 0 0 1 1 1 1 Ribosomal protein S6e Cupin_8 PF13621.1 EWC47650.1 - 5.3e-60 203.0 0.0 6.9e-60 202.6 0.0 1.1 1 0 0 1 1 1 1 Cupin-like domain JmjC PF02373.17 EWC47650.1 - 0.021 15.0 0.0 0.063 13.5 0.0 1.8 1 0 0 1 1 1 0 JmjC domain, hydroxylase Pribosyltran_N PF13793.1 EWC47652.1 - 1.1e-45 154.0 0.4 2e-44 150.0 0.1 2.2 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.1 EWC47652.1 - 1.6e-39 135.5 2.1 5.6e-32 110.9 0.6 2.6 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.22 EWC47652.1 - 3.3e-13 49.4 4.0 7.5e-13 48.3 0.3 2.8 3 0 0 3 3 3 1 Phosphoribosyl transferase domain UPRTase PF14681.1 EWC47652.1 - 0.00014 21.1 0.2 0.00027 20.1 0.2 1.5 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase IF-2B PF01008.12 EWC47652.1 - 0.0046 15.9 0.4 0.0078 15.2 0.2 1.3 1 0 0 1 1 1 1 Initiation factor 2 subunit family DUF4525 PF15027.1 EWC47652.1 - 0.14 11.6 0.3 0.37 10.3 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4525) DoxX_2 PF13564.1 EWC47653.1 - 0.13 12.2 0.0 0.19 11.7 0.0 1.3 1 0 0 1 1 1 0 DoxX-like family Methyltransf_23 PF13489.1 EWC47655.1 - 1.1e-18 67.4 0.0 1.8e-18 66.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EWC47655.1 - 1.5e-08 34.9 0.0 4.4e-08 33.4 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 EWC47655.1 - 9.4e-08 31.7 0.0 9.4e-07 28.5 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EWC47655.1 - 9.7e-08 32.4 0.0 2.9e-07 30.8 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EWC47655.1 - 1.6e-07 31.8 0.0 2.1e-06 28.2 0.0 2.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EWC47655.1 - 0.00019 21.7 0.0 0.00049 20.4 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 EWC47655.1 - 0.0032 16.5 0.1 0.015 14.3 0.0 2.0 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_26 PF13659.1 EWC47655.1 - 0.0051 16.8 0.0 0.013 15.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Inhibitor_I53 PF11714.3 EWC47655.1 - 0.27 11.2 1.0 0.62 10.0 0.7 1.5 1 0 0 1 1 1 0 Thrombin inhibitor Madanin CRAL_TRIO PF00650.15 EWC47656.1 - 8.2e-12 44.8 0.0 1.2e-11 44.4 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.10 EWC47656.1 - 0.0044 17.1 0.0 0.0082 16.2 0.0 1.4 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain DUF4573 PF15140.1 EWC47656.1 - 0.0067 16.0 14.8 0.02 14.4 7.3 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4573) UBA PF00627.26 EWC47656.1 - 0.15 11.9 0.1 0.28 11.0 0.0 1.5 1 0 0 1 1 1 0 UBA/TS-N domain Ribosomal_S8e PF01201.17 EWC47657.1 - 2e-47 160.6 3.4 2.3e-47 160.4 2.3 1.1 1 0 0 1 1 1 1 Ribosomal protein S8e SMAP PF15477.1 EWC47657.1 - 1.4 9.2 4.1 0.81 10.0 0.8 2.3 2 1 0 2 2 2 0 Small acidic protein family Glyco_hydro_63 PF03200.11 EWC47659.1 - 6.5e-09 34.2 1.9 4.3e-07 28.1 1.3 3.1 1 1 0 1 1 1 1 Mannosyl oligosaccharide glucosidase OSCP PF00213.13 EWC47660.1 - 1.1e-42 145.8 1.0 1.3e-42 145.5 0.7 1.1 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit vATP-synt_E PF01991.13 EWC47660.1 - 0.063 12.5 0.1 0.12 11.6 0.0 1.4 1 0 0 1 1 1 0 ATP synthase (E/31 kDa) subunit MMR_HSR1 PF01926.18 EWC47661.1 - 1e-05 25.4 0.0 2.8e-05 24.0 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.11 EWC47661.1 - 0.1 11.7 0.0 1.2 8.2 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function, DUF258 Utp12 PF04003.7 EWC47662.1 - 6.7e-20 71.0 0.3 1.2e-19 70.2 0.2 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family Bromodomain PF00439.20 EWC47663.1 - 3.8e-46 154.9 2.7 3e-26 91.1 0.6 2.7 2 0 0 2 2 2 2 Bromodomain Bap31 PF05529.7 EWC47663.1 - 1.3 8.4 2.6 1.2 8.5 0.3 2.0 2 0 0 2 2 2 0 B-cell receptor-associated protein 31-like RMF PF04957.7 EWC47664.1 - 0.034 13.8 0.1 0.074 12.7 0.0 1.6 1 0 0 1 1 1 0 Ribosome modulation factor DHHW PF14286.1 EWC47664.1 - 0.12 11.7 0.6 0.12 11.6 0.4 1.1 1 0 0 1 1 1 0 DHHW protein DUF663 PF04950.7 EWC47665.1 - 1.5e-92 309.7 0.0 2e-92 309.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF663) AARP2CN PF08142.7 EWC47665.1 - 3.3e-16 58.5 0.0 9e-16 57.1 0.0 1.8 1 0 0 1 1 1 1 AARP2CN (NUC121) domain K167R PF08065.7 EWC47665.1 - 6.2 6.9 11.0 13 5.9 0.4 2.5 2 0 0 2 2 2 0 K167R (NUC007) repeat BING4CT PF08149.6 EWC47666.1 - 4.4e-37 125.4 0.0 2e-36 123.3 0.0 2.2 2 0 0 2 2 2 1 BING4CT (NUC141) domain WD40 PF00400.27 EWC47666.1 - 7e-07 28.9 0.0 0.0025 17.6 0.0 3.7 4 0 0 4 4 4 2 WD domain, G-beta repeat Coatomer_WDAD PF04053.9 EWC47666.1 - 0.002 17.0 0.0 0.004 16.0 0.0 1.4 1 0 0 1 1 1 1 Coatomer WD associated region eIF2A PF08662.6 EWC47666.1 - 0.035 13.8 0.1 0.3 10.7 0.1 2.1 1 1 1 2 2 2 0 Eukaryotic translation initiation factor eIF2A SPO11_like PF03533.9 EWC47667.1 - 0.018 14.9 1.0 1.2 9.1 0.0 2.8 2 0 0 2 2 2 0 SPO11 homologue RNase_PH PF01138.16 EWC47668.1 - 8.7e-07 29.3 1.2 3e-06 27.5 0.0 2.2 3 0 0 3 3 3 1 3' exoribonuclease family, domain 1 RINGv PF12906.2 EWC47670.1 - 7.9e-12 45.0 4.6 1.2e-11 44.4 3.2 1.3 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.1 EWC47670.1 - 0.00027 20.6 6.3 0.0004 20.1 4.4 1.3 1 0 0 1 1 1 1 Ring finger domain Phi_1 PF04674.7 EWC47670.1 - 0.13 11.3 0.0 0.2 10.8 0.0 1.2 1 0 0 1 1 1 0 Phosphate-induced protein 1 conserved region Proteasome PF00227.21 EWC47671.1 - 3.2e-61 205.9 0.0 4.6e-61 205.4 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 EWC47671.1 - 1.4e-11 43.4 0.3 3.6e-11 42.1 0.0 1.8 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature V-SNARE PF05008.10 EWC47674.1 - 1.2e-22 79.8 2.2 1.2e-22 79.8 1.5 1.8 2 0 0 2 2 2 1 Vesicle transport v-SNARE protein N-terminus V-SNARE_C PF12352.3 EWC47674.1 - 4.3e-20 71.5 2.7 4.3e-20 71.5 1.8 2.7 4 0 0 4 4 4 1 Snare region anchored in the vesicle membrane C-terminus Fusion_gly PF00523.13 EWC47674.1 - 0.0041 15.2 3.5 0.068 11.2 0.3 2.3 2 0 0 2 2 2 2 Fusion glycoprotein F0 Sec20 PF03908.8 EWC47674.1 - 0.016 14.8 1.0 0.054 13.1 0.2 2.2 2 1 0 2 2 2 0 Sec20 Cytochrom_B562 PF07361.6 EWC47674.1 - 0.039 14.3 1.4 0.32 11.4 0.6 2.3 1 1 1 2 2 2 0 Cytochrome b562 DUF4407 PF14362.1 EWC47674.1 - 0.043 12.7 5.1 0.082 11.8 3.5 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Dodecin PF07311.7 EWC47674.1 - 0.21 11.6 1.3 0.22 11.6 0.0 1.6 2 0 0 2 2 2 0 Dodecin DUF3359 PF11839.3 EWC47674.1 - 1.9 8.9 5.8 27 5.1 0.0 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF3359) Laminin_I PF06008.9 EWC47674.1 - 3.7 6.7 11.4 78 2.4 8.1 2.5 1 1 0 1 1 1 0 Laminin Domain I V_ATPase_I PF01496.14 EWC47674.1 - 4.6 4.9 5.8 0.24 9.2 0.6 1.3 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Mob1_phocein PF03637.12 EWC47675.1 - 6.6e-66 221.2 0.0 8e-66 221.0 0.0 1.0 1 0 0 1 1 1 1 Mob1/phocein family Exo70 PF03081.10 EWC47675.1 - 0.099 11.4 0.0 0.13 10.9 0.0 1.1 1 0 0 1 1 1 0 Exo70 exocyst complex subunit DUF2011 PF09428.5 EWC47676.1 - 5.1e-20 71.6 15.0 3.4e-18 65.7 10.4 2.1 1 1 0 1 1 1 1 Fungal protein of unknown function (DUF2011) PGC7_Stella PF15549.1 EWC47676.1 - 3.2 7.7 9.7 5 7.0 6.7 1.2 1 0 0 1 1 1 0 PGC7/Stella/Dppa3 domain SPX PF03105.14 EWC47677.1 - 1.8e-46 159.1 1.9 2.4e-46 158.7 1.3 1.1 1 0 0 1 1 1 1 SPX domain Na_sulph_symp PF00939.14 EWC47677.1 - 1.1e-23 83.8 44.3 1.8e-23 83.2 30.7 1.2 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.11 EWC47677.1 - 2.3e-14 52.7 49.4 1.6e-13 50.0 18.3 2.3 1 1 1 2 2 2 2 Citrate transporter SNF2_N PF00176.18 EWC47678.1 - 2.4e-28 98.8 0.0 1.2e-26 93.1 0.0 2.3 2 0 0 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.26 EWC47678.1 - 0.13 12.1 0.0 0.28 11.0 0.0 1.5 1 0 0 1 1 1 0 Helicase conserved C-terminal domain MFS_1 PF07690.11 EWC47680.1 - 4.5e-10 38.7 34.7 3.6e-09 35.7 23.3 2.5 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EWC47680.1 - 0.0024 16.5 12.6 0.0024 16.5 8.7 2.8 2 2 1 3 3 3 1 Sugar (and other) transporter Phage_Coat_Gp8 PF05371.7 EWC47680.1 - 0.029 13.9 1.2 0.062 12.8 0.8 1.5 1 0 0 1 1 1 0 Phage major coat protein, Gp8 Pkinase PF00069.20 EWC47681.1 - 2.2e-60 204.0 0.0 3.1e-60 203.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC47681.1 - 5.9e-32 110.7 0.0 8.5e-31 106.9 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.6 EWC47681.1 - 0.12 11.0 0.0 0.18 10.5 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Kdo PF06293.9 EWC47681.1 - 0.22 10.5 0.0 0.38 9.7 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Stc1 PF12898.2 EWC47682.1 - 3.3e-17 62.2 6.0 9.6e-17 60.8 4.2 1.8 1 0 0 1 1 1 1 Stc1 domain UPRTase PF14681.1 EWC47687.1 - 5.1e-39 133.6 0.1 9.8e-39 132.6 0.1 1.5 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase HAD PF12710.2 EWC47687.1 - 1.6e-07 31.6 0.0 3e-07 30.8 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase AAA_17 PF13207.1 EWC47687.1 - 1.4e-05 25.9 0.0 3.8e-05 24.4 0.0 1.8 1 1 0 1 1 1 1 AAA domain Hydrolase PF00702.21 EWC47687.1 - 8e-05 23.1 0.0 0.00013 22.4 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase AAA_18 PF13238.1 EWC47687.1 - 0.00015 22.0 0.0 0.00048 20.4 0.0 1.9 1 0 0 1 1 1 1 AAA domain Pribosyltran PF00156.22 EWC47687.1 - 0.0017 18.0 0.4 0.066 12.9 0.3 2.9 1 1 0 1 1 1 1 Phosphoribosyl transferase domain AAA_33 PF13671.1 EWC47687.1 - 0.0018 18.1 0.0 0.032 14.0 0.0 2.7 2 0 0 2 2 2 1 AAA domain ArgK PF03308.11 EWC47687.1 - 0.0045 15.8 0.0 0.0086 14.8 0.0 1.4 1 0 0 1 1 1 1 ArgK protein KAP_NTPase PF07693.9 EWC47687.1 - 0.0046 16.0 0.0 0.0076 15.2 0.0 1.5 1 0 0 1 1 1 1 KAP family P-loop domain AAA_30 PF13604.1 EWC47687.1 - 0.0069 15.9 0.0 3.8 7.0 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.1 EWC47687.1 - 0.01 15.8 0.1 0.058 13.3 0.1 2.2 1 1 0 1 1 1 0 AAA ATPase domain SKI PF01202.17 EWC47687.1 - 0.012 15.4 0.4 0.055 13.3 0.0 2.3 2 0 0 2 2 1 0 Shikimate kinase Viral_helicase1 PF01443.13 EWC47687.1 - 0.015 14.8 0.0 0.03 13.8 0.0 1.5 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.1 EWC47687.1 - 0.019 15.1 0.2 0.33 11.0 0.0 2.7 2 0 0 2 2 2 0 AAA domain PRTase_2 PF15609.1 EWC47687.1 - 0.019 14.2 0.2 0.036 13.3 0.1 1.5 1 0 0 1 1 1 0 Phosphoribosyl transferase Peptidase_U4 PF03419.8 EWC47687.1 - 0.17 10.8 0.2 0.26 10.2 0.1 1.2 1 0 0 1 1 1 0 Sporulation factor SpoIIGA Ank_2 PF12796.2 EWC47688.1 - 0.00034 20.8 0.1 0.02 15.1 0.1 3.0 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Pkinase_Tyr PF07714.12 EWC47689.1 - 0.00097 18.2 0.0 0.0025 16.9 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase HeLo PF14479.1 EWC47689.1 - 0.002 17.9 1.7 0.005 16.6 1.2 1.6 1 0 0 1 1 1 1 Prion-inhibition and propagation Pkinase PF00069.20 EWC47689.1 - 0.043 12.9 0.0 0.082 12.0 0.0 1.4 1 0 0 1 1 1 0 Protein kinase domain Glyco_hydro_61 PF03443.9 EWC47691.1 - 7.8e-65 218.7 0.0 1e-64 218.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 Dppa2_A PF14049.1 EWC47691.1 - 0.1 12.4 2.6 0.24 11.2 1.8 1.6 1 0 0 1 1 1 0 Dppa2/4 conserved region in higher vertebrates CAP59_mtransfer PF11735.3 EWC47692.1 - 3.6e-51 173.7 0.0 4.7e-51 173.3 0.0 1.1 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 LEP503 PF15221.1 EWC47692.1 - 0.013 15.2 0.1 0.039 13.6 0.0 1.8 1 0 0 1 1 1 0 Lens epithelial cell protein LEP503 Ank_2 PF12796.2 EWC47693.1 - 2.6e-67 223.1 12.3 6.7e-19 68.0 0.1 6.8 2 2 3 6 6 6 6 Ankyrin repeats (3 copies) Ank PF00023.25 EWC47693.1 - 2.4e-47 156.4 35.3 5.9e-07 28.9 0.1 14.7 15 0 0 15 15 15 10 Ankyrin repeat Ank_3 PF13606.1 EWC47693.1 - 7.8e-41 134.0 17.9 0.00034 20.5 0.0 14.3 15 0 0 15 15 15 8 Ankyrin repeat Ank_4 PF13637.1 EWC47693.1 - 2.6e-32 110.5 6.5 1.3e-06 28.7 0.0 10.7 4 3 7 11 11 11 9 Ankyrin repeats (many copies) Ank_5 PF13857.1 EWC47693.1 - 5.3e-30 102.7 22.0 8.7e-07 28.9 0.2 10.9 4 3 7 11 11 11 8 Ankyrin repeats (many copies) DUF676 PF05057.9 EWC47693.1 - 6.6e-05 22.2 0.0 0.00012 21.4 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.8 EWC47693.1 - 0.00011 21.8 0.0 0.00024 20.7 0.0 1.5 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_6 PF12697.2 EWC47693.1 - 0.0012 18.7 0.4 0.0061 16.4 0.0 2.5 3 0 0 3 3 3 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EWC47693.1 - 0.0093 15.7 0.0 0.028 14.1 0.0 1.8 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF829 PF05705.9 EWC47693.1 - 0.046 13.4 0.0 0.09 12.4 0.0 1.4 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF829) Lipase_3 PF01764.20 EWC47693.1 - 0.072 12.7 0.0 0.22 11.1 0.0 1.8 1 0 0 1 1 1 0 Lipase (class 3) LCAT PF02450.10 EWC47693.1 - 0.1 11.5 0.0 0.26 10.1 0.0 1.6 2 0 0 2 2 2 0 Lecithin:cholesterol acyltransferase DUF946 PF06101.6 EWC47694.1 - 6.4e-13 47.5 2.3 1.9e-12 45.9 1.6 1.7 1 1 0 1 1 1 1 Plant protein of unknown function (DUF946) NPP1 PF05630.6 EWC47694.1 - 0.037 13.7 0.2 0.054 13.2 0.1 1.2 1 0 0 1 1 1 0 Necrosis inducing protein (NPP1) Spherulin4 PF12138.3 EWC47695.1 - 3.5e-33 115.0 0.6 4.6e-33 114.7 0.4 1.1 1 0 0 1 1 1 1 Spherulation-specific family 4 GST_C PF00043.20 EWC47696.1 - 4.1e-08 33.1 0.1 6.2e-08 32.5 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 EWC47696.1 - 9.2e-05 22.2 0.1 0.00015 21.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 EWC47696.1 - 0.0008 19.8 0.0 0.0017 18.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain PBD PF00786.23 EWC47697.1 - 0.001 19.4 0.2 0.0048 17.2 0.0 2.3 2 0 0 2 2 2 1 P21-Rho-binding domain DUF89 PF01937.14 EWC47698.1 - 2e-114 382.0 0.0 2.4e-114 381.8 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF89 Acyltransferase PF01553.16 EWC47699.1 - 3.2e-24 84.8 0.0 4.9e-24 84.2 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase RVT_1 PF00078.22 EWC47701.1 - 0.098 11.9 0.0 0.25 10.6 0.0 1.6 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) tRNA-synt_2b PF00587.20 EWC47702.1 - 4.5e-69 231.4 0.1 6.9e-69 230.8 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 EWC47702.1 - 2e-20 72.5 0.0 5.9e-20 71.0 0.0 1.9 1 0 0 1 1 1 1 Anticodon binding domain ETRAMP PF09716.5 EWC47703.1 - 0.18 11.7 0.1 0.31 11.0 0.1 1.4 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Epimerase PF01370.16 EWC47704.1 - 3.2e-18 66.0 0.0 6.2e-18 65.1 0.0 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 EWC47704.1 - 5.7e-11 41.6 0.0 9.1e-11 40.9 0.0 1.4 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.1 EWC47704.1 - 7.2e-10 39.1 0.0 3.9e-09 36.7 0.0 1.9 2 0 0 2 2 2 1 NADH(P)-binding Polysacc_synt_2 PF02719.10 EWC47704.1 - 4.6e-09 35.5 0.0 7.3e-09 34.9 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NmrA PF05368.8 EWC47704.1 - 1.1e-07 31.3 0.1 5.1e-07 29.1 0.0 1.9 2 0 0 2 2 2 1 NmrA-like family NAD_binding_4 PF07993.7 EWC47704.1 - 1.2e-06 27.7 0.0 2.3e-05 23.4 0.0 2.1 1 1 0 1 1 1 1 Male sterility protein adh_short PF00106.20 EWC47704.1 - 5.2e-06 26.4 0.0 1.1e-05 25.4 0.0 1.5 2 0 0 2 2 2 1 short chain dehydrogenase RmlD_sub_bind PF04321.12 EWC47704.1 - 0.078 11.8 0.0 0.3 9.9 0.0 1.8 2 0 0 2 2 2 0 RmlD substrate binding domain Saccharop_dh PF03435.13 EWC47704.1 - 0.085 11.8 0.0 0.15 11.0 0.0 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase MBOAT_2 PF13813.1 EWC47705.1 - 6.5e-09 35.7 6.6 6.5e-09 35.7 4.6 2.1 2 1 0 2 2 2 1 Membrane bound O-acyl transferase family MARVEL PF01284.18 EWC47706.1 - 9.7e-05 22.2 9.2 0.00015 21.6 6.4 1.2 1 0 0 1 1 1 1 Membrane-associating domain NdhL PF10716.4 EWC47706.1 - 0.022 14.5 1.1 0.045 13.5 0.8 1.5 1 0 0 1 1 1 0 NADH dehydrogenase transmembrane subunit DUF1634 PF07843.6 EWC47706.1 - 0.39 10.3 0.1 0.39 10.3 0.0 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1634) ABC2_membrane_5 PF13346.1 EWC47706.1 - 1.9 7.7 6.8 3.7 6.7 4.7 1.4 1 1 0 1 1 1 0 ABC-2 family transporter protein Glyco_hydro_6 PF01341.12 EWC47707.1 - 2.9e-101 338.8 0.5 4.2e-101 338.3 0.4 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 6 CBM_1 PF00734.13 EWC47707.1 - 1.4e-12 47.0 6.9 3.3e-12 45.8 4.8 1.7 1 0 0 1 1 1 1 Fungal cellulose binding domain SOG2 PF10428.4 EWC47707.1 - 1.4 7.4 16.2 1.9 7.0 11.2 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Plasmodium_Vir PF05795.6 EWC47707.1 - 1.5 7.9 4.2 2.2 7.3 2.9 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein DUF566 PF04484.7 EWC47707.1 - 4.2 6.7 8.5 6.1 6.2 5.9 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF566) CheW PF01584.14 EWC47709.1 - 0.029 13.8 0.9 0.77 9.2 0.1 2.5 2 0 0 2 2 2 0 CheW-like domain TPR_11 PF13414.1 EWC47710.1 - 1.5e-34 117.4 22.7 8.3e-09 34.9 0.0 9.8 8 2 2 10 10 10 6 TPR repeat TPR_1 PF00515.23 EWC47710.1 - 1.5e-27 94.0 27.9 0.002 17.6 0.0 10.8 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_2 PF07719.12 EWC47710.1 - 1.8e-27 92.9 34.0 0.0015 18.2 0.0 12.3 11 0 0 11 11 11 8 Tetratricopeptide repeat TPR_16 PF13432.1 EWC47710.1 - 4.8e-25 87.6 28.1 0.00048 20.7 0.6 10.5 8 2 3 11 11 11 7 Tetratricopeptide repeat TPR_12 PF13424.1 EWC47710.1 - 1.2e-21 76.4 34.1 3.9e-07 29.9 1.2 9.8 7 3 3 10 10 10 7 Tetratricopeptide repeat TPR_14 PF13428.1 EWC47710.1 - 6.1e-18 63.6 15.3 0.0007 20.0 0.1 12.1 9 3 4 13 13 13 3 Tetratricopeptide repeat TPR_19 PF14559.1 EWC47710.1 - 6.6e-18 64.8 22.1 1.1e-05 25.6 0.0 10.3 10 2 2 12 12 11 5 Tetratricopeptide repeat TPR_8 PF13181.1 EWC47710.1 - 3.9e-17 60.6 34.5 0.0081 15.8 0.0 11.6 13 0 0 13 13 11 7 Tetratricopeptide repeat TPR_6 PF13174.1 EWC47710.1 - 7.7e-16 57.3 20.3 0.032 14.6 0.0 13.2 15 0 0 15 15 12 2 Tetratricopeptide repeat TPR_17 PF13431.1 EWC47710.1 - 2.1e-11 43.0 13.9 0.46 10.8 0.0 10.9 11 0 0 11 11 10 1 Tetratricopeptide repeat TPR_7 PF13176.1 EWC47710.1 - 7.1e-09 34.8 23.7 0.0013 18.3 0.2 9.8 11 0 0 11 11 10 2 Tetratricopeptide repeat Apc3 PF12895.2 EWC47710.1 - 1.1e-06 28.6 22.9 0.094 12.8 0.0 7.8 5 2 2 8 8 8 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.1 EWC47710.1 - 2.4e-05 24.1 1.0 3.1 7.7 0.0 5.2 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_3 PF07720.7 EWC47710.1 - 0.0015 18.2 6.6 4 7.3 0.0 5.3 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_10 PF13374.1 EWC47710.1 - 0.0097 15.8 19.4 3.1 7.8 0.1 7.5 7 0 0 7 7 7 1 Tetratricopeptide repeat SBP56 PF05694.6 EWC47711.1 - 0.00029 19.4 0.0 0.041 12.3 0.0 2.6 2 1 0 2 2 2 2 56kDa selenium binding protein (SBP56) Lactonase PF10282.4 EWC47711.1 - 0.0069 15.5 0.0 1.4 7.8 0.0 2.6 2 1 0 2 2 2 2 Lactonase, 7-bladed beta-propeller Cupin_1 PF00190.17 EWC47712.1 - 3.3e-24 84.9 0.2 7.3e-14 51.4 0.0 2.2 2 0 0 2 2 2 2 Cupin Cupin_2 PF07883.6 EWC47712.1 - 3.8e-20 71.1 2.2 1.4e-12 46.8 0.1 2.3 2 0 0 2 2 2 2 Cupin domain Cupin_3 PF05899.7 EWC47712.1 - 7.8e-06 25.1 0.0 0.00043 19.6 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF861) Cupin_6 PF12852.2 EWC47712.1 - 0.00035 20.2 0.1 0.58 9.7 0.0 2.3 2 0 0 2 2 2 2 Cupin AraC_binding PF02311.14 EWC47712.1 - 0.066 12.9 0.1 0.42 10.2 0.0 2.2 2 0 0 2 2 2 0 AraC-like ligand binding domain Glyco_hydro_61 PF03443.9 EWC47713.1 - 1.9e-34 119.3 0.0 4.2e-34 118.2 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 CBM_1 PF00734.13 EWC47713.1 - 8.5e-15 54.1 21.1 8.9e-08 31.6 9.5 2.7 2 0 0 2 2 2 2 Fungal cellulose binding domain Toxin_7 PF05980.7 EWC47713.1 - 0.72 9.9 2.5 1.5 8.9 1.8 1.5 1 0 0 1 1 1 0 Toxin 7 CBM_1 PF00734.13 EWC47714.1 - 8.4e-24 82.9 39.3 3.1e-11 42.7 4.3 3.9 4 0 0 4 4 4 3 Fungal cellulose binding domain EGF_MSP1_1 PF12946.2 EWC47714.1 - 0.00094 18.9 1.4 1.2 8.9 0.1 2.6 2 0 0 2 2 2 2 MSP1 EGF domain 1 Lustrin_cystein PF14625.1 EWC47714.1 - 0.0025 17.8 8.3 0.45 10.6 0.8 2.8 2 0 0 2 2 2 2 Lustrin, cysteine-rich repeated domain FYRN PF05964.9 EWC47714.1 - 0.12 11.8 5.0 2.2 7.7 0.3 2.4 2 0 0 2 2 2 0 F/Y-rich N-terminus CC PF04942.9 EWC47714.1 - 3.4 7.6 15.0 1.1 9.2 0.6 3.0 3 0 0 3 3 3 0 CC domain Granulin PF00396.13 EWC47714.1 - 5.1 7.2 7.3 22 5.2 0.7 2.8 2 0 0 2 2 2 0 Granulin SurE PF01975.12 EWC47716.1 - 3.5e-39 134.1 0.0 6.2e-39 133.3 0.0 1.3 1 0 0 1 1 1 1 Survival protein SurE Brix PF04427.13 EWC47717.1 - 8.7e-37 126.6 0.0 2.2e-36 125.3 0.0 1.6 2 0 0 2 2 2 1 Brix domain Daxx PF03344.10 EWC47717.1 - 0.041 12.3 11.5 0.051 12.0 8.0 1.2 1 0 0 1 1 1 0 Daxx Family Nop14 PF04147.7 EWC47717.1 - 0.043 11.7 13.7 0.056 11.3 9.5 1.2 1 0 0 1 1 1 0 Nop14-like family BUD22 PF09073.5 EWC47717.1 - 0.26 10.2 19.0 0.39 9.7 13.2 1.2 1 0 0 1 1 1 0 BUD22 RRN3 PF05327.6 EWC47717.1 - 1.4 6.9 2.8 2.9 5.9 2.0 1.5 1 1 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 CDC45 PF02724.9 EWC47717.1 - 3.3 5.6 6.1 5.7 4.8 4.2 1.4 1 0 0 1 1 1 0 CDC45-like protein RIX1 PF08167.7 EWC47718.1 - 2.8e-30 105.1 3.1 2.8e-30 105.1 2.2 2.4 2 0 0 2 2 2 1 rRNA processing/ribosome biogenesis TPR_11 PF13414.1 EWC47719.1 - 0.00024 20.6 0.2 0.15 11.6 0.1 4.1 3 1 1 4 4 4 1 TPR repeat TPR_17 PF13431.1 EWC47719.1 - 0.00032 20.6 0.0 12 6.4 0.0 5.7 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_8 PF13181.1 EWC47719.1 - 0.00068 19.2 0.0 0.048 13.4 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.12 EWC47719.1 - 0.00091 18.9 3.9 1.5 8.8 0.0 5.2 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_19 PF14559.1 EWC47719.1 - 0.0015 18.8 1.0 1.9 8.8 0.1 4.3 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.23 EWC47719.1 - 0.12 12.0 0.1 11 5.8 0.0 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.1 EWC47719.1 - 0.32 11.7 12.2 0.69 10.6 0.0 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat ABC_tran PF00005.22 EWC47721.1 - 1.6e-47 161.2 0.1 3e-23 82.6 0.0 2.9 3 0 0 3 3 2 2 ABC transporter ABC_tran_2 PF12848.2 EWC47721.1 - 1.4e-21 76.0 4.1 1.4e-21 76.0 2.8 3.0 4 0 0 4 4 2 1 ABC transporter AAA_21 PF13304.1 EWC47721.1 - 5.1e-18 66.0 1.0 0.0043 17.0 0.0 4.3 2 2 1 4 4 4 4 AAA domain SMC_N PF02463.14 EWC47721.1 - 1.4e-09 37.4 1.3 0.26 10.5 0.0 4.4 3 1 1 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 EWC47721.1 - 6e-08 32.1 0.2 0.0031 17.0 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_17 PF13207.1 EWC47721.1 - 1.1e-07 32.6 0.0 0.0089 16.8 0.0 3.1 3 0 0 3 3 2 2 AAA domain AAA_18 PF13238.1 EWC47721.1 - 1.2e-07 32.1 0.2 0.014 15.7 0.0 3.1 3 0 0 3 3 3 2 AAA domain AAA_23 PF13476.1 EWC47721.1 - 1.3e-07 32.1 3.5 0.063 13.6 0.0 3.4 3 0 0 3 3 3 2 AAA domain DUF258 PF03193.11 EWC47721.1 - 3.4e-07 29.5 0.0 0.00046 19.4 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 Miro PF08477.8 EWC47721.1 - 7.2e-07 29.7 0.0 0.013 15.9 0.0 2.7 2 0 0 2 2 2 2 Miro-like protein AAA_22 PF13401.1 EWC47721.1 - 8.6e-07 29.1 0.0 0.023 14.8 0.0 2.8 2 0 0 2 2 2 2 AAA domain NACHT PF05729.7 EWC47721.1 - 4.9e-06 26.3 0.1 0.066 12.8 0.0 2.6 2 0 0 2 2 2 2 NACHT domain MobB PF03205.9 EWC47721.1 - 5.2e-06 26.2 0.1 0.0012 18.5 0.0 2.8 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B MMR_HSR1 PF01926.18 EWC47721.1 - 1.3e-05 25.1 0.0 0.054 13.4 0.0 3.1 3 0 0 3 3 2 2 50S ribosome-binding GTPase AAA PF00004.24 EWC47721.1 - 1.6e-05 25.1 0.4 0.39 10.9 0.0 3.4 3 2 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 EWC47721.1 - 1.9e-05 24.7 0.0 0.18 11.7 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain Arch_ATPase PF01637.13 EWC47721.1 - 2.4e-05 24.1 0.5 0.096 12.3 0.0 3.3 3 0 0 3 3 3 1 Archaeal ATPase AAA_14 PF13173.1 EWC47721.1 - 5e-05 23.1 0.0 0.21 11.4 0.0 3.0 2 1 0 2 2 2 2 AAA domain AAA_33 PF13671.1 EWC47721.1 - 8e-05 22.5 0.2 0.056 13.3 0.0 2.8 3 0 0 3 3 2 1 AAA domain AAA_28 PF13521.1 EWC47721.1 - 9e-05 22.4 0.0 0.3 11.0 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_15 PF13175.1 EWC47721.1 - 0.00011 21.4 0.0 0.24 10.3 0.0 3.1 3 1 0 4 4 3 2 AAA ATPase domain RNA_helicase PF00910.17 EWC47721.1 - 0.00012 22.2 0.6 0.8 9.9 0.0 3.2 3 0 0 3 3 3 2 RNA helicase NB-ARC PF00931.17 EWC47721.1 - 0.00012 21.0 0.1 0.25 10.1 0.0 2.8 2 1 0 2 2 2 2 NB-ARC domain AAA_5 PF07728.9 EWC47721.1 - 0.00028 20.6 0.1 0.65 9.7 0.1 2.5 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_10 PF12846.2 EWC47721.1 - 0.00073 19.0 0.4 1.4 8.2 0.0 2.7 2 0 0 2 2 2 2 AAA-like domain AAA_25 PF13481.1 EWC47721.1 - 0.00076 18.9 0.0 2.6 7.4 0.0 3.2 3 0 0 3 3 3 1 AAA domain Dynamin_N PF00350.18 EWC47721.1 - 0.002 17.9 0.3 3.7 7.3 0.0 3.7 2 1 1 3 3 3 0 Dynamin family ArgK PF03308.11 EWC47721.1 - 0.003 16.3 0.5 0.41 9.3 0.0 2.8 3 0 0 3 3 3 1 ArgK protein DUF815 PF05673.8 EWC47721.1 - 0.0046 15.9 0.0 1.8 7.4 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF815) ATP-synt_ab PF00006.20 EWC47721.1 - 0.0075 15.7 0.0 0.049 13.1 0.0 2.2 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain AAA_30 PF13604.1 EWC47721.1 - 0.0089 15.6 0.2 2.3 7.7 0.0 3.6 4 0 0 4 4 3 1 AAA domain NTPase_1 PF03266.10 EWC47721.1 - 0.0093 15.6 0.1 1.4 8.5 0.0 2.6 2 0 0 2 2 2 1 NTPase DUF87 PF01935.12 EWC47721.1 - 0.011 15.5 1.1 6.1 6.5 0.0 3.4 3 1 1 4 4 4 0 Domain of unknown function DUF87 DAP3 PF10236.4 EWC47721.1 - 0.012 14.5 1.4 4.3 6.1 0.0 2.8 3 0 0 3 3 3 0 Mitochondrial ribosomal death-associated protein 3 MarR_2 PF12802.2 EWC47721.1 - 0.013 15.1 0.0 0.49 10.0 0.0 2.7 2 0 0 2 2 2 0 MarR family SbcCD_C PF13558.1 EWC47721.1 - 0.018 14.9 2.4 0.51 10.2 0.0 3.4 3 1 0 3 3 2 0 Putative exonuclease SbcCD, C subunit PduV-EutP PF10662.4 EWC47721.1 - 0.02 14.3 0.2 7.9 5.9 0.0 3.0 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation VirE PF05272.6 EWC47721.1 - 0.024 14.1 0.1 1.6 8.1 0.0 2.8 3 0 0 3 3 3 0 Virulence-associated protein E Rad17 PF03215.10 EWC47721.1 - 0.047 12.3 0.4 6.9 5.2 0.0 2.8 3 0 0 3 3 3 0 Rad17 cell cycle checkpoint protein Ras PF00071.17 EWC47721.1 - 0.049 13.0 0.1 10 5.4 0.0 2.7 3 0 0 3 3 2 0 Ras family FeoB_N PF02421.13 EWC47721.1 - 0.052 12.8 0.0 3.9 6.7 0.0 2.4 2 0 0 2 2 2 0 Ferrous iron transport protein B DUF2813 PF11398.3 EWC47721.1 - 0.055 12.5 0.8 8.4 5.3 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2813) AAA_24 PF13479.1 EWC47721.1 - 0.28 10.7 3.6 7 6.1 0.0 3.2 4 0 0 4 4 3 0 AAA domain Git3 PF11710.3 EWC47722.1 - 2e-18 66.7 6.7 3.4e-18 65.9 4.7 1.4 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 7tm_1 PF00001.16 EWC47722.1 - 6.5e-11 41.8 0.0 9.6e-11 41.3 0.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Dicty_CAR PF05462.6 EWC47722.1 - 8.7e-06 24.8 7.2 0.00067 18.6 5.1 2.1 2 0 0 2 2 2 2 Slime mold cyclic AMP receptor Git3_C PF11970.3 EWC47722.1 - 0.0011 18.6 0.0 0.0032 17.1 0.0 1.7 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 C-term DUF92 PF01940.11 EWC47722.1 - 0.27 10.3 5.9 1.9 7.5 0.1 2.8 2 1 0 3 3 3 0 Integral membrane protein DUF92 Fungal_trans PF04082.13 EWC47723.1 - 2.2e-16 59.5 0.0 3.5e-16 58.8 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EWC47723.1 - 4.7e-09 35.9 11.9 8e-09 35.2 8.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Stn1 PF10451.4 EWC47724.1 - 2.1e-10 39.9 0.0 2.5e-10 39.6 0.0 1.0 1 0 0 1 1 1 1 Telomere regulation protein Stn1 tRNA_anti-codon PF01336.20 EWC47724.1 - 0.00039 20.2 0.1 0.013 15.3 0.0 2.1 1 1 1 2 2 2 1 OB-fold nucleic acid binding domain DUF461 PF04314.8 EWC47724.1 - 0.022 14.3 0.1 0.03 13.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF461) Fungal_trans PF04082.13 EWC47725.1 - 6.7e-16 57.9 0.0 1.2e-15 57.0 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EWC47725.1 - 1.8e-08 34.1 14.6 2.7e-08 33.5 10.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Zn_clus PF00172.13 EWC47726.1 - 0.018 14.9 10.0 0.042 13.7 6.9 1.7 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain 4F5 PF04419.9 EWC47726.1 - 4.2 8.1 8.2 22 5.8 0.8 2.6 2 0 0 2 2 2 0 4F5 protein family DUF1777 PF08648.7 EWC47726.1 - 4.9 6.8 15.8 48 3.6 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1777) DUF399 PF04187.8 EWC47727.1 - 0.02 14.4 0.4 0.026 14.0 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF399 Peptidase_S8 PF00082.17 EWC47730.1 - 5e-40 137.4 10.2 7.6e-40 136.8 7.1 1.2 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.11 EWC47730.1 - 3.6e-12 46.6 1.3 8.3e-12 45.5 0.9 1.7 1 0 0 1 1 1 1 Peptidase inhibitor I9 CBM_1 PF00734.13 EWC47731.1 - 6.8e-13 48.0 12.0 1.7e-12 46.7 8.3 1.8 1 0 0 1 1 1 1 Fungal cellulose binding domain MIP-T3 PF10243.4 EWC47732.1 - 0.92 7.9 9.0 1.1 7.6 6.2 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Erp_C PF06780.6 EWC47733.1 - 7.4 6.4 12.7 0.32 10.8 1.6 3.0 3 0 0 3 3 3 0 Erp protein C-terminus HALZ PF02183.13 EWC47734.1 - 0.17 11.6 11.4 0.23 11.2 0.8 3.7 2 1 1 3 3 3 0 Homeobox associated leucine zipper Shugoshin_N PF07558.6 EWC47734.1 - 3.6 7.3 12.9 0.74 9.5 0.2 3.5 3 0 0 3 3 3 0 Shugoshin N-terminal coiled-coil region bZIP_1 PF00170.16 EWC47734.1 - 5.5 7.0 24.4 0.62 10.0 0.9 5.1 3 2 2 5 5 5 0 bZIP transcription factor DUF1664 PF07889.7 EWC47734.1 - 8.2 6.2 8.5 11 5.8 2.5 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) NACHT PF05729.7 EWC47735.1 - 0.042 13.5 0.0 0.064 12.9 0.0 1.2 1 0 0 1 1 1 0 NACHT domain DUF1090 PF06476.7 EWC47739.1 - 0.15 11.7 0.1 0.65 9.6 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1090) Drc1-Sld2 PF11719.3 EWC47743.1 - 0.13 11.2 1.8 0.16 11.0 1.2 1.1 1 0 0 1 1 1 0 DNA replication and checkpoint protein MRFAP1 PF15155.1 EWC47744.1 - 0.025 14.9 0.2 0.1 12.9 0.1 1.8 2 0 0 2 2 2 0 MORF4 family-associated protein1 CRISPR_Cas2 PF09827.4 EWC47744.1 - 0.087 12.9 0.1 1 9.5 0.0 2.2 1 1 1 2 2 2 0 CRISPR associated protein Cas2 DCP1 PF06058.8 EWC47745.1 - 1.2e-08 35.0 0.0 1e-06 28.7 0.0 2.2 2 0 0 2 2 2 2 Dcp1-like decapping family PRANC PF09372.5 EWC47747.1 - 0.0042 17.0 0.0 0.013 15.4 0.0 1.8 1 0 0 1 1 1 1 PRANC domain F-box PF00646.28 EWC47747.1 - 0.0044 16.6 0.1 0.011 15.3 0.0 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 EWC47747.1 - 0.014 15.0 0.2 0.035 13.8 0.2 1.7 1 0 0 1 1 1 0 F-box-like NAD_kinase PF01513.16 EWC47748.1 - 1e-45 155.7 0.0 1.9e-45 154.8 0.0 1.3 1 0 0 1 1 1 1 ATP-NAD kinase Exo_endo_phos PF03372.18 EWC47748.1 - 1.1e-15 58.2 0.0 2.4e-15 57.1 0.0 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RhoGAP PF00620.22 EWC47748.1 - 0.018 14.6 0.0 0.041 13.4 0.0 1.6 1 0 0 1 1 1 0 RhoGAP domain NAD_binding_10 PF13460.1 EWC47749.1 - 0.00019 21.4 0.0 0.00026 21.0 0.0 1.3 1 0 0 1 1 1 1 NADH(P)-binding NAD_binding_4 PF07993.7 EWC47749.1 - 0.0037 16.2 0.0 0.05 12.5 0.0 2.0 1 1 0 2 2 2 1 Male sterility protein Polysacc_synt_2 PF02719.10 EWC47749.1 - 0.12 11.3 0.0 0.27 10.1 0.0 1.6 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein Cyclin_N PF00134.18 EWC47750.1 - 2.6e-07 30.2 0.0 3.5e-06 26.5 0.0 2.1 2 0 0 2 2 2 1 Cyclin, N-terminal domain AflR PF08493.5 EWC47750.1 - 0.13 11.2 2.9 0.19 10.7 2.0 1.2 1 0 0 1 1 1 0 Aflatoxin regulatory protein WD40 PF00400.27 EWC47751.1 - 1.2e-25 88.4 16.6 2.6e-06 27.0 0.0 6.2 6 0 0 6 6 6 5 WD domain, G-beta repeat B_lectin PF01453.19 EWC47751.1 - 0.0059 16.4 0.9 0.61 9.9 0.0 2.9 2 1 1 3 3 3 1 D-mannose binding lectin F-box PF00646.28 EWC47752.1 - 0.0001 21.8 0.2 0.0058 16.2 0.1 3.2 3 0 0 3 3 3 1 F-box domain F-box-like PF12937.2 EWC47752.1 - 0.00033 20.3 0.0 0.00089 18.9 0.0 1.8 1 1 0 1 1 1 1 F-box-like LRR_4 PF12799.2 EWC47752.1 - 0.033 13.8 0.5 6.8 6.4 0.2 4.0 4 0 0 4 4 4 0 Leucine Rich repeats (2 copies) PQ-loop PF04193.9 EWC47753.1 - 1.7e-15 56.2 10.7 1.5e-07 30.8 1.3 2.9 2 0 0 2 2 2 2 PQ loop repeat DUF1469 PF07332.6 EWC47753.1 - 0.016 14.8 4.2 0.016 14.8 2.9 2.8 4 0 0 4 4 4 0 Protein of unknown function (DUF1469) Pkinase PF00069.20 EWC47756.1 - 2.9e-16 59.4 0.0 4e-10 39.2 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 EWC47756.1 - 5.9e-11 41.9 0.0 3.2e-08 32.9 0.0 2.3 2 1 0 2 2 2 2 Protein tyrosine kinase Zip PF02535.17 EWC47756.1 - 1 8.2 6.3 1.8 7.5 4.4 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Abhydrolase_3 PF07859.8 EWC47758.1 - 6.6e-36 123.8 0.0 1.2e-35 123.0 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold DNA_methylase PF00145.12 EWC47759.1 - 1.1e-35 123.3 0.0 6.1e-23 81.4 0.0 2.3 1 1 1 2 2 2 2 C-5 cytosine-specific DNA methylase Methyltransf_15 PF09445.5 EWC47759.1 - 0.00064 19.3 0.2 0.0012 18.4 0.1 1.4 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_26 PF13659.1 EWC47759.1 - 0.011 15.7 0.0 0.027 14.5 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain SNF2_N PF00176.18 EWC47760.1 - 4.9e-41 140.4 0.0 7.3e-41 139.8 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 EWC47760.1 - 4.4e-10 39.2 0.0 1.1e-09 38.0 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EWC47760.1 - 1.8e-06 27.9 0.0 4.7e-06 26.5 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SAM_2 PF07647.12 EWC47760.1 - 0.00034 20.4 0.0 0.0021 17.8 0.0 2.2 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) DUF1707 PF08044.6 EWC47760.1 - 5.6 6.7 9.7 0.47 10.2 0.2 3.5 4 0 0 4 4 4 0 Domain of unknown function (DUF1707) UQ_con PF00179.21 EWC47763.1 - 4.2e-44 149.3 0.0 5.6e-44 148.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 EWC47763.1 - 8.3e-05 22.3 0.0 0.00015 21.5 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic E2 family B UBA_3 PF09288.5 EWC47763.1 - 0.001 18.5 0.0 0.002 17.6 0.0 1.5 1 0 0 1 1 1 1 Fungal ubiquitin-associated domain RWD PF05773.17 EWC47763.1 - 0.049 13.5 0.0 0.078 12.8 0.0 1.5 1 0 0 1 1 1 0 RWD domain ABC1 PF03109.11 EWC47764.1 - 1.8e-32 111.8 0.0 2.9e-32 111.1 0.0 1.4 1 0 0 1 1 1 1 ABC1 family Pkinase_Tyr PF07714.12 EWC47765.1 - 6e-09 35.3 0.0 1.9e-08 33.6 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 EWC47765.1 - 3.5e-06 26.3 0.0 5.8e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain AAA PF00004.24 EWC47766.1 - 4.1e-41 140.2 0.0 7.4e-41 139.4 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 EWC47766.1 - 1.7e-07 31.4 0.1 6.1e-05 23.1 0.1 2.4 1 1 0 1 1 1 1 AAA domain AAA_2 PF07724.9 EWC47766.1 - 3.4e-06 27.0 0.0 9.8e-06 25.5 0.0 1.7 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.8 EWC47766.1 - 1.3e-05 24.2 0.0 2.2e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_5 PF07728.9 EWC47766.1 - 2.8e-05 23.8 0.0 7.3e-05 22.5 0.0 1.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 EWC47766.1 - 0.0005 20.1 0.1 0.0021 18.0 0.1 2.0 1 1 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.7 EWC47766.1 - 0.00055 19.0 0.0 0.00098 18.2 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus Zeta_toxin PF06414.7 EWC47766.1 - 0.0038 16.3 0.0 0.0066 15.5 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_28 PF13521.1 EWC47766.1 - 0.0044 17.0 0.2 0.013 15.4 0.0 2.0 2 0 0 2 2 1 1 AAA domain IstB_IS21 PF01695.12 EWC47766.1 - 0.0063 15.9 0.0 0.013 14.9 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein KaiC PF06745.8 EWC47766.1 - 0.0068 15.5 0.2 0.28 10.2 0.1 2.7 2 1 1 3 3 3 1 KaiC AAA_19 PF13245.1 EWC47766.1 - 0.0084 15.8 0.2 0.02 14.6 0.2 1.6 1 0 0 1 1 1 1 Part of AAA domain NACHT PF05729.7 EWC47766.1 - 0.0094 15.6 0.2 0.42 10.2 0.0 2.6 2 1 1 3 3 3 1 NACHT domain TIP49 PF06068.8 EWC47766.1 - 0.01 14.5 0.4 0.02 13.5 0.0 1.7 2 1 0 2 2 2 0 TIP49 C-terminus AAA_17 PF13207.1 EWC47766.1 - 0.011 16.5 0.2 0.031 15.1 0.1 1.9 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.1 EWC47766.1 - 0.012 15.4 0.0 0.025 14.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.1 EWC47766.1 - 0.013 15.3 0.0 0.025 14.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_3 PF07726.6 EWC47766.1 - 0.017 14.7 0.0 0.034 13.7 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PhoH PF02562.11 EWC47766.1 - 0.024 13.8 0.8 0.14 11.3 0.1 2.1 2 0 0 2 2 2 0 PhoH-like protein NB-ARC PF00931.17 EWC47766.1 - 0.029 13.2 0.0 0.044 12.6 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_25 PF13481.1 EWC47766.1 - 0.033 13.5 1.3 0.41 10.0 0.2 2.3 1 1 0 2 2 2 0 AAA domain RNA_helicase PF00910.17 EWC47766.1 - 0.036 14.2 0.0 0.078 13.1 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_18 PF13238.1 EWC47766.1 - 0.038 14.2 0.0 0.067 13.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.16 EWC47766.1 - 0.042 13.0 0.1 0.082 12.0 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_24 PF13479.1 EWC47766.1 - 0.047 13.2 0.1 0.14 11.7 0.1 1.7 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.10 EWC47766.1 - 0.14 11.8 0.3 0.94 9.1 0.1 2.5 2 1 0 2 2 2 0 NTPase DUF2075 PF09848.4 EWC47766.1 - 0.15 11.0 0.0 0.2 10.5 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) LRR_8 PF13855.1 EWC47768.1 - 0.072 12.8 1.2 6.3 6.6 0.0 3.4 4 0 0 4 4 4 0 Leucine rich repeat LRR_4 PF12799.2 EWC47768.1 - 8.9 6.0 7.2 13 5.5 0.1 3.5 4 1 0 4 4 4 0 Leucine Rich repeats (2 copies) Metallophos PF00149.23 EWC47769.1 - 1.1e-09 38.0 1.1 1.8e-09 37.2 0.8 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF3638 PF12340.3 EWC47772.1 - 8.8e-85 283.3 2.2 1.5e-84 282.5 1.5 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3638) DUF3645 PF12359.3 EWC47772.1 - 1e-13 50.1 0.1 2.4e-13 48.9 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3645) zf-DHHC PF01529.15 EWC47773.1 - 0.0038 16.6 0.2 0.0065 15.8 0.1 1.5 1 0 0 1 1 1 1 DHHC palmitoyltransferase Aldo_ket_red PF00248.16 EWC47774.1 - 9.5e-54 182.1 0.0 1.1e-53 181.9 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Frankia_peptide PF14407.1 EWC47774.1 - 0.061 13.0 0.2 0.29 10.8 0.0 2.0 2 0 0 2 2 2 0 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. Aminotran_1_2 PF00155.16 EWC47775.1 - 1.4e-80 270.9 0.0 2e-80 270.4 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.14 EWC47775.1 - 6.1e-06 25.2 0.6 2.9e-05 22.9 0.0 2.2 2 0 0 2 2 2 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.15 EWC47775.1 - 0.00036 18.9 0.0 0.00059 18.2 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.12 EWC47775.1 - 0.003 16.6 0.1 0.0057 15.7 0.0 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family ECH PF00378.15 EWC47776.1 - 9.7e-37 126.3 0.1 2.5e-36 125.0 0.1 1.6 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family Peptidase_S49 PF01343.13 EWC47776.1 - 0.069 12.9 0.1 13 5.5 0.0 2.4 2 0 0 2 2 2 0 Peptidase family S49 DUF1729 PF08354.5 EWC47776.1 - 0.1 12.4 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1729) Citrate_synt PF00285.16 EWC47777.1 - 4.9e-117 390.6 0.0 6.2e-117 390.2 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase Mid1 PF12929.2 EWC47778.1 - 6.5e-104 348.0 4.6 6e-79 265.7 1.0 2.2 1 1 1 2 2 2 2 Stretch-activated Ca2+-permeable channel component Fz PF01392.17 EWC47778.1 - 0.12 12.6 2.4 0.67 10.3 0.3 2.4 2 0 0 2 2 2 0 Fz domain CFEM PF05730.6 EWC47779.1 - 1.8e-13 50.0 13.5 2.2e-10 40.2 2.3 2.3 2 0 0 2 2 2 2 CFEM domain Gamma-thionin PF00304.15 EWC47779.1 - 5.5 7.0 13.2 3 7.9 0.7 2.6 2 1 0 2 2 2 0 Gamma-thionin family adh_short PF00106.20 EWC47781.1 - 5e-15 55.8 1.4 7.5e-15 55.2 0.1 1.8 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.5 EWC47781.1 - 0.014 15.1 0.0 0.022 14.4 0.0 1.3 1 0 0 1 1 1 0 KR domain Pkinase PF00069.20 EWC47782.1 - 1.8e-70 237.0 0.1 1.8e-70 237.0 0.1 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC47782.1 - 1.6e-51 174.8 0.1 3.5e-51 173.7 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.23 EWC47782.1 - 7.9e-22 77.4 0.5 2.4e-21 75.8 0.0 2.2 2 0 0 2 2 2 1 P21-Rho-binding domain Kinase-like PF14531.1 EWC47782.1 - 2.9e-07 29.7 0.0 7.2e-07 28.4 0.0 1.6 1 0 0 1 1 1 1 Kinase-like PH_11 PF15413.1 EWC47782.1 - 3e-06 27.4 0.0 8.7e-06 25.9 0.0 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.24 EWC47782.1 - 0.00023 21.3 0.0 0.00056 20.0 0.0 1.7 1 0 0 1 1 1 1 PH domain APH PF01636.18 EWC47782.1 - 0.013 15.2 0.1 0.013 15.2 0.0 3.4 2 2 1 3 3 3 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 EWC47782.1 - 0.047 12.5 0.1 0.084 11.6 0.1 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Topoisom_I_N PF02919.10 EWC47782.1 - 0.71 9.1 9.3 1.5 8.0 6.4 1.5 1 0 0 1 1 1 0 Eukaryotic DNA topoisomerase I, DNA binding fragment CH PF00307.26 EWC47783.1 - 1.6e-34 118.1 0.2 4.3e-18 65.3 0.0 2.8 2 0 0 2 2 2 2 Calponin homology (CH) domain EFhand_Ca_insen PF08726.5 EWC47783.1 - 5.1e-26 90.4 0.2 4e-25 87.5 0.3 2.4 2 0 0 2 2 2 1 Ca2+ insensitive EF hand CAMSAP_CH PF11971.3 EWC47783.1 - 4.1e-10 39.1 0.0 1e-06 28.2 0.0 2.8 2 0 0 2 2 2 2 CAMSAP CH domain EF-hand_8 PF13833.1 EWC47783.1 - 0.00081 18.9 0.2 0.0038 16.8 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.1 EWC47783.1 - 0.002 17.8 1.5 0.012 15.4 0.1 3.1 4 0 0 4 4 4 1 EF-hand domain EF-hand_1 PF00036.27 EWC47783.1 - 0.0048 16.1 0.1 0.34 10.3 0.0 3.0 2 0 0 2 2 2 1 EF hand Spectrin PF00435.16 EWC47783.1 - 0.007 16.6 5.6 0.093 13.0 0.1 2.6 2 0 0 2 2 2 1 Spectrin repeat MM_CoA_mutase PF01642.17 EWC47783.1 - 0.13 10.3 1.5 0.22 9.6 1.0 1.2 1 0 0 1 1 1 0 Methylmalonyl-CoA mutase Sp38 PF07354.7 EWC47783.1 - 0.15 10.6 0.5 0.26 9.8 0.0 1.5 2 0 0 2 2 2 0 Zona-pellucida-binding protein (Sp38) Cu_amine_oxid PF01179.15 EWC47784.1 - 3e-169 563.1 0.0 3.6e-169 562.8 0.0 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN3 PF02728.11 EWC47784.1 - 5.6e-18 64.8 0.1 2.5e-17 62.7 0.0 2.1 2 0 0 2 2 2 1 Copper amine oxidase, N3 domain Cu_amine_oxidN2 PF02727.11 EWC47784.1 - 1.1e-12 47.8 0.0 1.9e-12 47.0 0.0 1.4 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain FAM194 PF14977.1 EWC47787.1 - 0.013 14.4 0.2 0.022 13.7 0.1 1.3 1 0 0 1 1 1 0 FAM194 protein TIR-like PF10137.4 EWC47787.1 - 0.095 12.3 0.5 0.16 11.5 0.4 1.5 1 0 0 1 1 1 0 Predicted nucleotide-binding protein containing TIR-like domain GAGA_bind PF06217.7 EWC47787.1 - 0.37 10.7 6.7 0.48 10.3 4.6 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family Paramyxo_ncap PF00973.14 EWC47787.1 - 0.54 8.8 7.8 0.77 8.3 5.4 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein RR_TM4-6 PF06459.7 EWC47787.1 - 0.7 9.7 11.3 0.83 9.4 7.8 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 bZIP_1 PF00170.16 EWC47788.1 - 2.3e-08 33.8 17.9 3.9e-08 33.1 12.4 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 EWC47788.1 - 1.8e-05 24.4 24.9 3.2e-05 23.6 14.6 2.4 1 1 1 2 2 2 2 Basic region leucine zipper bZIP_Maf PF03131.12 EWC47788.1 - 0.02 15.2 13.4 0.034 14.4 9.3 1.4 1 0 0 1 1 1 0 bZIP Maf transcription factor GAS PF13851.1 EWC47788.1 - 0.15 11.1 11.6 0.17 11.0 7.5 1.5 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding APG6 PF04111.7 EWC47788.1 - 0.26 10.3 9.1 0.36 9.8 6.3 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 Bap31 PF05529.7 EWC47788.1 - 3.4 7.0 9.7 6.6 6.1 6.7 1.6 1 1 0 1 1 1 0 B-cell receptor-associated protein 31-like V_ATPase_I PF01496.14 EWC47788.1 - 5.9 4.6 5.9 8 4.1 4.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TEX13 PF15186.1 EWC47788.1 - 6.3 6.3 10.1 9.8 5.7 7.0 1.2 1 0 0 1 1 1 0 Testis-expressed sequence 13 protein family Erf4 PF10256.4 EWC47790.1 - 5.5e-30 103.6 0.1 4.8e-29 100.6 0.1 2.1 2 0 0 2 2 2 1 Golgin subfamily A member 7/ERF4 family TPR_11 PF13414.1 EWC47791.1 - 2.7e-12 46.1 2.3 1.9e-06 27.4 0.5 3.1 2 1 1 3 3 3 2 TPR repeat TPR_2 PF07719.12 EWC47791.1 - 3.3e-06 26.5 4.1 0.0044 16.8 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.23 EWC47791.1 - 1.5e-05 24.3 1.2 0.0005 19.5 0.0 3.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.1 EWC47791.1 - 0.00013 22.2 0.9 0.0037 17.5 0.0 3.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_9 PF13371.1 EWC47791.1 - 0.00039 20.2 1.5 0.015 15.1 0.1 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.1 EWC47791.1 - 0.00087 19.3 0.0 0.0057 16.7 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.1 EWC47791.1 - 0.0043 16.9 1.8 0.35 10.8 0.0 3.4 3 1 0 3 3 3 1 Tetratricopeptide repeat DUF3856 PF12968.2 EWC47791.1 - 0.014 15.2 5.4 0.028 14.2 2.0 2.4 2 1 0 2 2 2 0 Domain of Unknown Function (DUF3856) TPR_6 PF13174.1 EWC47791.1 - 0.02 15.3 0.4 0.11 12.9 0.0 2.5 2 0 0 2 2 1 0 Tetratricopeptide repeat Virulence_fact PF13769.1 EWC47791.1 - 0.048 13.5 0.2 2.2 8.2 0.0 2.2 1 1 1 2 2 2 0 Virulence factor TPR_16 PF13432.1 EWC47791.1 - 0.1 13.3 0.1 0.1 13.3 0.0 3.2 3 1 1 4 4 3 0 Tetratricopeptide repeat TPR_14 PF13428.1 EWC47791.1 - 0.21 12.3 4.3 0.86 10.4 0.0 3.8 4 1 1 5 5 5 0 Tetratricopeptide repeat RNA_pol_I_A49 PF06870.7 EWC47792.1 - 1.9e-47 161.7 0.1 2.1e-47 161.5 0.0 1.0 1 0 0 1 1 1 1 A49-like RNA polymerase I associated factor DUF2042 PF09743.4 EWC47792.1 - 0.057 12.7 0.0 8.8 5.5 0.0 2.8 2 1 0 3 3 3 0 Uncharacterized conserved protein (DUF2042) CAF1 PF04857.15 EWC47793.1 - 3.3e-67 226.5 0.0 3.3e-67 226.5 0.0 1.7 2 0 0 2 2 2 1 CAF1 family ribonuclease AIP3 PF03915.8 EWC47793.1 - 1.3 7.8 9.7 2 7.2 6.7 1.1 1 0 0 1 1 1 0 Actin interacting protein 3 Ilar_coat PF01787.11 EWC47793.1 - 3.5 7.1 10.0 0.06 12.9 2.1 1.5 2 0 0 2 2 2 0 Ilarvirus coat protein DUF4203 PF13886.1 EWC47794.1 - 6.3e-32 110.7 24.4 8.6e-32 110.3 16.9 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4203) SAPS PF04499.10 EWC47794.1 - 0.029 13.0 3.2 0.14 10.7 0.0 2.1 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein Plasmodium_Vir PF05795.6 EWC47794.1 - 3.7 6.6 3.9 11 5.0 2.7 1.7 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Glyco_transf_22 PF03901.12 EWC47795.1 - 1.2e-62 212.2 21.9 1.5e-62 212.0 15.2 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family CYSTM PF12734.2 EWC47797.1 - 0.007 16.4 35.6 0.007 16.4 24.7 4.6 3 2 0 3 3 3 1 Cysteine-rich TM module stress tolerance WWbp PF10349.4 EWC47797.1 - 5.4 7.9 17.7 7.9 7.3 12.2 1.3 1 0 0 1 1 1 0 WW-domain ligand protein ARS2 PF04959.8 EWC47797.1 - 5.9 7.0 6.3 7.1 6.7 4.4 1.0 1 0 0 1 1 1 0 Arsenite-resistance protein 2 MUG113 PF13455.1 EWC47798.1 - 1.1e-26 93.1 2.8 2.1e-26 92.1 0.8 2.3 2 0 0 2 2 2 1 Meiotically up-regulated gene 113 T5orf172 PF10544.4 EWC47798.1 - 4.5e-18 65.4 2.6 2.2e-17 63.2 1.8 2.2 1 1 0 1 1 1 1 T5orf172 domain Skp1 PF01466.14 EWC47799.1 - 6.8e-40 134.9 1.3 1.2e-39 134.1 0.9 1.4 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.10 EWC47799.1 - 4.1e-23 81.2 0.0 9.9e-23 80.0 0.0 1.6 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain DUF4375 PF14300.1 EWC47799.1 - 0.097 12.6 0.8 0.13 12.2 0.1 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4375) eIF-6 PF01912.13 EWC47801.1 - 2.2e-82 274.9 0.9 2.9e-82 274.6 0.6 1.1 1 0 0 1 1 1 1 eIF-6 family HAD_2 PF13419.1 EWC47803.1 - 4.9e-16 59.4 0.0 5.7e-16 59.2 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 EWC47803.1 - 0.00018 21.9 0.0 0.0002 21.8 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 EWC47803.1 - 0.0036 17.4 0.0 0.0067 16.6 0.0 1.4 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.1 EWC47803.1 - 0.032 14.1 0.0 0.06 13.2 0.0 1.5 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Pkinase PF00069.20 EWC47804.1 - 2e-58 197.6 0.0 3.6e-58 196.7 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC47804.1 - 1.5e-30 106.1 0.0 2.3e-30 105.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EWC47804.1 - 1.1e-12 47.5 0.0 5.6e-11 41.9 0.0 2.7 1 1 2 3 3 3 1 Kinase-like Kdo PF06293.9 EWC47804.1 - 0.00085 18.4 0.0 0.0013 17.8 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Cucumo_coat PF00760.13 EWC47805.1 - 0.055 12.4 0.2 0.093 11.6 0.1 1.3 1 0 0 1 1 1 0 Cucumovirus coat protein AT_hook PF02178.14 EWC47805.1 - 0.3 10.8 15.6 2.2 8.2 3.1 2.9 2 0 0 2 2 2 0 AT hook motif TFIIA PF03153.8 EWC47805.1 - 0.51 10.1 20.8 1 9.1 14.4 1.5 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FAM60A PF15396.1 EWC47805.1 - 6.8 6.3 7.2 17 5.0 5.0 1.6 1 0 0 1 1 1 0 Protein Family FAM60A Vpu PF00558.14 EWC47806.1 - 0.079 12.5 0.0 0.19 11.3 0.0 1.6 1 0 0 1 1 1 0 Vpu protein Phostensin_N PF13916.1 EWC47806.1 - 0.3 11.1 5.1 0.79 9.7 3.6 1.7 1 0 0 1 1 1 0 PP1-regulatory protein, Phostensin N-terminal XPC-binding PF09280.6 EWC47807.1 - 1.7e-24 85.0 7.8 3.3e-24 84.1 5.4 1.5 1 0 0 1 1 1 1 XPC-binding domain UBA PF00627.26 EWC47807.1 - 4.6e-22 77.2 2.5 4.7e-11 42.1 0.0 2.9 3 0 0 3 3 3 2 UBA/TS-N domain ubiquitin PF00240.18 EWC47807.1 - 4.9e-17 61.0 0.0 8e-17 60.4 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 EWC47807.1 - 5.1e-07 29.2 0.0 1.1e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.1 EWC47807.1 - 0.001 18.9 0.1 0.0026 17.6 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBA_3 PF09288.5 EWC47807.1 - 0.0045 16.5 0.0 0.22 11.1 0.0 2.3 2 0 0 2 2 2 1 Fungal ubiquitin-associated domain DUF2407 PF10302.4 EWC47807.1 - 0.012 15.8 0.0 0.024 14.8 0.0 1.5 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Ubiquitin_2 PF14560.1 EWC47807.1 - 0.021 15.0 0.0 0.045 13.9 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-like domain WIYLD PF10440.4 EWC47807.1 - 0.099 12.5 0.0 9.1 6.2 0.0 2.3 2 0 0 2 2 2 0 Ubiquitin-binding WIYLD domain MCM_N PF14551.1 EWC47807.1 - 0.12 12.9 0.0 0.25 11.8 0.0 1.5 1 0 0 1 1 1 0 MCM N-terminal domain Myb_DNA-bind_6 PF13921.1 EWC47808.1 - 2.4e-05 24.3 0.1 5.4e-05 23.2 0.1 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 EWC47808.1 - 0.018 15.0 0.2 0.043 13.8 0.2 1.7 1 1 0 1 1 1 0 Myb-like DNA-binding domain Mg_trans_NIPA PF05653.9 EWC47809.1 - 1.3e-56 191.8 6.8 5.5e-52 176.5 1.9 2.1 2 0 0 2 2 2 2 Magnesium transporter NIPA EmrE PF13536.1 EWC47809.1 - 2.9e-06 27.4 0.4 2.9e-06 27.4 0.3 3.0 3 1 0 3 3 3 1 Multidrug resistance efflux transporter EamA PF00892.15 EWC47809.1 - 0.002 18.1 0.9 0.002 18.1 0.6 4.1 3 1 0 4 4 4 1 EamA-like transporter family SSB PF00436.20 EWC47810.1 - 6.1e-20 71.0 0.2 7.8e-20 70.6 0.2 1.1 1 0 0 1 1 1 1 Single-strand binding protein family Adeno_E3_14_5 PF04834.7 EWC47812.1 - 0.013 15.9 0.0 0.013 15.9 0.0 1.4 2 0 0 2 2 2 0 Early E3 14.5 kDa protein PepSY_TM_2 PF13703.1 EWC47812.1 - 0.03 14.4 0.3 0.049 13.8 0.2 1.2 1 0 0 1 1 1 0 PepSY-associated TM helix HemY_N PF07219.8 EWC47812.1 - 0.037 13.5 0.0 0.057 12.9 0.0 1.2 1 0 0 1 1 1 0 HemY protein N-terminus DUF3366 PF11846.3 EWC47812.1 - 0.053 13.4 0.1 0.065 13.1 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3366) Herpes_glycop PF01528.11 EWC47812.1 - 0.1 11.3 0.1 0.11 11.1 0.1 1.1 1 0 0 1 1 1 0 Herpesvirus glycoprotein M PLDc_N PF13396.1 EWC47812.1 - 0.13 11.9 3.1 0.4 10.3 2.2 1.8 1 1 0 1 1 1 0 Phospholipase_D-nuclease N-terminal Sporozoite_P67 PF05642.6 EWC47812.1 - 9.9 3.8 8.2 12 3.6 5.7 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen GPI-anchored PF10342.4 EWC47813.1 - 1.9e-20 73.1 2.3 1.9e-20 73.1 1.6 2.4 2 1 1 3 3 3 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family KAR9 PF08580.5 EWC47813.1 - 4.1 5.5 8.3 4.6 5.3 5.7 1.0 1 0 0 1 1 1 0 Yeast cortical protein KAR9 STE3 PF02076.10 EWC47814.1 - 8.7e-49 166.1 18.9 1.2e-48 165.6 13.1 1.1 1 0 0 1 1 1 1 Pheromone A receptor HTH_31 PF13560.1 EWC47814.1 - 0.0032 17.6 0.9 4.5 7.5 0.1 3.1 2 0 0 2 2 2 2 Helix-turn-helix domain DUF2051 PF09738.4 EWC47814.1 - 1.3 8.2 7.5 2 7.6 5.2 1.2 1 0 0 1 1 1 0 Double stranded RNA binding protein (DUF2051) Spt4 PF06093.8 EWC47815.1 - 1e-27 95.8 0.2 1.3e-27 95.4 0.1 1.2 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger FYVE_2 PF02318.11 EWC47815.1 - 0.1 12.5 0.1 0.18 11.7 0.1 1.4 1 0 0 1 1 1 0 FYVE-type zinc finger ABC_membrane PF00664.18 EWC47816.1 - 6.8e-83 278.2 32.1 2.6e-42 145.1 5.2 2.5 3 0 0 3 3 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 EWC47816.1 - 2.1e-50 170.5 1.0 5e-29 101.3 0.0 3.2 3 0 0 3 3 3 2 ABC transporter SMC_N PF02463.14 EWC47816.1 - 2.5e-09 36.6 5.6 0.00043 19.5 0.1 4.2 2 2 1 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.1 EWC47816.1 - 4.7e-06 26.7 0.3 0.047 13.6 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain MMR_HSR1 PF01926.18 EWC47816.1 - 1.1e-05 25.3 0.0 0.15 12.0 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase DUF258 PF03193.11 EWC47816.1 - 3.1e-05 23.2 0.1 0.022 13.9 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_29 PF13555.1 EWC47816.1 - 8.9e-05 21.9 0.2 0.66 9.5 0.0 3.0 3 0 0 3 3 3 2 P-loop containing region of AAA domain AAA_23 PF13476.1 EWC47816.1 - 0.00022 21.6 1.5 0.0081 16.5 0.3 2.7 2 1 0 2 2 2 1 AAA domain AAA_25 PF13481.1 EWC47816.1 - 0.0004 19.8 0.2 0.26 10.6 0.1 2.5 2 0 0 2 2 2 2 AAA domain AAA_21 PF13304.1 EWC47816.1 - 0.0024 17.8 2.6 5.2 6.9 0.1 4.2 4 0 0 4 4 4 1 AAA domain AAA_10 PF12846.2 EWC47816.1 - 0.0024 17.3 0.4 0.89 8.9 0.0 2.4 2 0 0 2 2 2 2 AAA-like domain Miro PF08477.8 EWC47816.1 - 0.0046 17.4 1.0 2.9 8.4 0.0 2.7 2 0 0 2 2 2 2 Miro-like protein Dynamin_N PF00350.18 EWC47816.1 - 0.011 15.6 1.4 0.61 9.8 0.0 2.7 2 0 0 2 2 2 0 Dynamin family AAA_30 PF13604.1 EWC47816.1 - 0.022 14.3 2.3 3.2 7.2 0.0 3.6 4 0 0 4 4 4 0 AAA domain DUF87 PF01935.12 EWC47816.1 - 0.027 14.2 2.6 1 9.1 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function DUF87 NACHT PF05729.7 EWC47816.1 - 0.038 13.6 2.0 0.1 12.2 0.1 2.5 2 0 0 2 2 2 0 NACHT domain RNA_helicase PF00910.17 EWC47816.1 - 0.11 12.6 0.0 12 6.1 0.0 2.6 2 0 0 2 2 2 0 RNA helicase DUF2841 PF11001.3 EWC47817.1 - 2.8e-36 124.1 0.2 5e-36 123.3 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2841) Cob_adeno_trans PF01923.13 EWC47818.1 - 0.032 14.0 0.3 0.037 13.8 0.2 1.1 1 0 0 1 1 1 0 Cobalamin adenosyltransferase DUF1515 PF07439.6 EWC47818.1 - 3.2 7.6 5.5 6.4 6.6 0.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1515) CN_hydrolase PF00795.17 EWC47819.1 - 2.9e-08 33.2 0.0 3.8e-07 29.6 0.0 2.2 1 1 0 1 1 1 1 Carbon-nitrogen hydrolase SDA1 PF05285.7 EWC47819.1 - 0.046 13.0 22.2 0.084 12.1 15.4 1.4 1 0 0 1 1 1 0 SDA1 Daxx PF03344.10 EWC47819.1 - 0.19 10.1 26.3 0.36 9.2 18.2 1.4 1 0 0 1 1 1 0 Daxx Family Paf1 PF03985.8 EWC47819.1 - 2.8 6.5 16.1 4.6 5.8 11.2 1.4 1 0 0 1 1 1 0 Paf1 UBA PF00627.26 EWC47820.1 - 2.4e-06 27.1 0.1 5.6e-06 26.0 0.1 1.7 1 0 0 1 1 1 1 UBA/TS-N domain UBA_4 PF14555.1 EWC47820.1 - 0.0002 20.8 0.0 0.00044 19.7 0.0 1.6 1 0 0 1 1 1 1 UBA-like domain CUE PF02845.11 EWC47820.1 - 0.036 13.5 0.0 0.077 12.5 0.0 1.6 1 0 0 1 1 1 0 CUE domain HLH PF00010.21 EWC47821.1 - 7.6e-13 47.9 0.6 1.5e-12 46.9 0.4 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF1759 PF03564.10 EWC47821.1 - 0.071 12.9 0.3 0.11 12.2 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1759) DUF904 PF06005.7 EWC47821.1 - 0.075 13.3 1.8 0.2 11.9 1.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF904) F-box-like PF12937.2 EWC47822.1 - 5.4e-05 22.8 0.0 0.00013 21.6 0.0 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EWC47822.1 - 8.7e-05 22.0 0.0 0.00018 21.0 0.0 1.5 1 0 0 1 1 1 1 F-box domain DUF1770 PF08589.5 EWC47823.1 - 1.9e-16 60.4 0.6 2.2e-16 60.2 0.4 1.0 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1770) His_biosynth PF00977.16 EWC47824.1 - 1.3e-31 109.6 0.0 1.6e-31 109.3 0.0 1.1 1 0 0 1 1 1 1 Histidine biosynthesis protein TPIP1 PF15338.1 EWC47824.1 - 0.022 14.6 0.0 0.055 13.3 0.0 1.7 1 0 0 1 1 1 0 p53-regulated apoptosis-inducing protein 1 End_beta_propel PF12217.3 EWC47824.1 - 0.058 12.0 0.0 0.083 11.5 0.0 1.2 1 0 0 1 1 1 0 Catalytic beta propeller domain of bacteriophage endosialidase Aminotran_3 PF00202.16 EWC47825.1 - 1.4e-93 313.4 0.0 1.7e-93 313.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Init_tRNA_PT PF04179.7 EWC47826.1 - 2.4e-123 412.3 0.0 2.9e-83 280.2 0.0 2.0 1 1 1 2 2 2 2 Initiator tRNA phosphoribosyl transferase STE PF02200.11 EWC47827.1 - 3.3e-61 204.2 0.2 7e-61 203.2 0.1 1.5 1 0 0 1 1 1 1 STE like transcription factor zf-C2H2 PF00096.21 EWC47827.1 - 5e-09 35.9 26.2 5.4e-06 26.4 2.5 3.5 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 EWC47827.1 - 7.8e-09 35.3 15.0 6e-08 32.6 3.3 3.5 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.1 EWC47827.1 - 5.7e-06 26.3 13.0 0.00023 21.2 1.8 3.1 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_6 PF13912.1 EWC47827.1 - 1.2e-05 25.0 2.3 3.1e-05 23.6 0.6 2.3 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 EWC47827.1 - 0.00012 22.0 3.6 0.0057 16.7 0.6 2.6 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 EWC47827.1 - 2.4 8.4 5.1 13 6.1 1.3 2.6 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-BED PF02892.10 EWC47827.1 - 4.6 7.0 7.2 5.6 6.7 3.0 2.2 1 1 1 2 2 2 0 BED zinc finger SOR_SNZ PF01680.12 EWC47828.1 - 3.4e-108 360.0 4.1 3.8e-108 359.8 2.4 1.4 2 0 0 2 2 2 1 SOR/SNZ family ThiG PF05690.9 EWC47828.1 - 9.6e-09 34.6 5.5 3.4e-07 29.6 0.1 2.5 2 1 0 2 2 2 2 Thiazole biosynthesis protein ThiG NanE PF04131.9 EWC47828.1 - 9.8e-05 21.3 0.6 0.032 13.1 0.0 3.2 3 0 0 3 3 3 1 Putative N-acetylmannosamine-6-phosphate epimerase IGPS PF00218.16 EWC47828.1 - 0.0025 16.9 0.0 0.062 12.3 0.0 2.4 2 0 0 2 2 2 1 Indole-3-glycerol phosphate synthase Dus PF01207.12 EWC47828.1 - 0.0069 15.2 1.1 0.62 8.8 0.0 2.4 2 1 0 2 2 2 1 Dihydrouridine synthase (Dus) FMN_dh PF01070.13 EWC47828.1 - 0.0097 14.7 0.0 0.23 10.2 0.0 2.2 2 0 0 2 2 2 1 FMN-dependent dehydrogenase NMO PF03060.10 EWC47828.1 - 0.01 14.9 5.6 0.033 13.3 0.2 2.4 2 1 0 2 2 2 0 Nitronate monooxygenase His_biosynth PF00977.16 EWC47828.1 - 0.012 14.8 0.4 0.13 11.5 0.0 2.6 3 0 0 3 3 3 0 Histidine biosynthesis protein OMPdecase PF00215.19 EWC47828.1 - 0.071 12.5 0.1 0.38 10.1 0.1 2.1 1 1 0 1 1 1 0 Orotidine 5'-phosphate decarboxylase / HUMPS family PPDK_N PF01326.14 EWC47828.1 - 0.12 11.3 0.4 0.22 10.5 0.3 1.3 1 0 0 1 1 1 0 Pyruvate phosphate dikinase, PEP/pyruvate binding domain Spo12 PF05032.7 EWC47829.1 - 6.3e-13 48.0 5.5 6.3e-13 48.0 3.8 1.7 2 0 0 2 2 2 1 Spo12 family DUF3729 PF12526.3 EWC47829.1 - 0.99 10.7 6.1 0.84 11.0 0.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3729) SET PF00856.23 EWC47830.1 - 8.4e-19 68.4 0.1 8.4e-19 68.4 0.1 3.3 3 3 0 3 3 3 1 SET domain WW PF00397.21 EWC47830.1 - 1.7e-11 43.7 3.9 3.9e-11 42.5 2.7 1.6 1 0 0 1 1 1 1 WW domain SRI PF08236.6 EWC47830.1 - 9.5e-06 25.4 5.0 9.5e-06 25.4 3.4 2.9 4 0 0 4 4 4 1 SRI (Set2 Rpb1 interacting) domain Med26 PF08711.6 EWC47830.1 - 0.0034 16.8 0.3 0.014 14.9 0.2 2.1 1 0 0 1 1 1 1 TFIIS helical bundle-like domain MFS_2 PF13347.1 EWC47832.1 - 5.3e-08 31.6 11.6 1.9e-07 29.8 5.3 2.9 2 1 0 2 2 2 1 MFS/sugar transport protein Na_H_Exchanger PF00999.16 EWC47833.1 - 6.7e-65 219.0 39.0 8.7e-65 218.6 27.1 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Atrophin-1 PF03154.10 EWC47833.1 - 0.86 7.6 3.4 1.4 6.9 2.3 1.2 1 0 0 1 1 1 0 Atrophin-1 family DUF4602 PF15375.1 EWC47834.1 - 8.3e-13 48.5 0.4 8.3e-13 48.5 0.3 2.5 2 1 0 2 2 2 1 Domain of unknown function (DUF4602) DUF605 PF04652.11 EWC47834.1 - 0.00067 19.1 19.3 0.00076 18.9 13.3 1.1 1 0 0 1 1 1 1 Vta1 like Nop14 PF04147.7 EWC47834.1 - 0.0067 14.4 14.0 0.0087 14.0 9.7 1.3 1 0 0 1 1 1 1 Nop14-like family CobT PF06213.7 EWC47834.1 - 0.11 11.5 15.6 0.22 10.5 10.8 1.5 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT eIF-3c_N PF05470.7 EWC47834.1 - 0.12 10.4 4.2 0.13 10.3 2.9 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Paf1 PF03985.8 EWC47834.1 - 1.6 7.4 12.2 2.9 6.5 8.5 1.3 1 0 0 1 1 1 0 Paf1 RRN3 PF05327.6 EWC47834.1 - 3.1 5.8 6.7 3.8 5.5 4.6 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Acyl-CoA_dh_1 PF00441.19 EWC47835.1 - 4.8e-33 114.3 0.2 8.7e-33 113.5 0.1 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.11 EWC47835.1 - 2e-13 50.8 0.0 3.9e-13 49.9 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.6 EWC47835.1 - 2.9e-13 50.2 0.1 5.3e-13 49.3 0.1 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.14 EWC47835.1 - 4.9e-12 45.1 0.0 1.1e-11 44.0 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain IF2_N PF04760.10 EWC47836.1 - 0.11 12.1 0.0 0.25 11.0 0.0 1.5 1 0 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region LTV PF04180.9 EWC47837.1 - 1.2e-69 235.8 23.5 1.9e-58 198.9 12.2 2.3 1 1 1 2 2 2 2 Low temperature viability protein Peptidase_C14 PF00656.17 EWC47838.1 - 4e-21 75.8 0.0 7.2e-21 74.9 0.0 1.4 1 0 0 1 1 1 1 Caspase domain Peptidase_C13 PF01650.13 EWC47838.1 - 0.11 11.7 0.5 2.1 7.5 0.1 2.5 2 1 0 2 2 2 0 Peptidase C13 family DUF4360 PF14273.1 EWC47839.1 - 6.9e-38 130.1 0.1 7.9e-38 129.9 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4360) DUF3419 PF11899.3 EWC47840.1 - 5.4e-134 446.6 0.1 7e-134 446.3 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3419) Methyltransf_23 PF13489.1 EWC47840.1 - 6.4e-12 45.4 0.0 5.7e-10 39.1 0.0 3.0 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_31 PF13847.1 EWC47840.1 - 1.4e-10 40.9 0.0 1.6e-05 24.5 0.0 3.2 3 0 0 3 3 3 3 Methyltransferase domain Methyltransf_12 PF08242.7 EWC47840.1 - 1.4e-09 38.2 0.0 1.5e-07 31.7 0.0 3.2 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_11 PF08241.7 EWC47840.1 - 2.8e-08 34.1 0.0 0.046 14.2 0.0 4.3 3 1 0 3 3 3 2 Methyltransferase domain Ubie_methyltran PF01209.13 EWC47840.1 - 8.2e-06 25.0 0.0 0.076 12.1 0.0 3.2 3 0 0 3 3 3 2 ubiE/COQ5 methyltransferase family Methyltransf_18 PF12847.2 EWC47840.1 - 1.5e-05 25.5 0.0 5.9e-05 23.6 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_26 PF13659.1 EWC47840.1 - 0.00032 20.7 0.1 0.015 15.2 0.0 2.9 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_8 PF05148.10 EWC47840.1 - 0.02 14.5 0.0 0.35 10.4 0.0 2.6 3 0 0 3 3 3 0 Hypothetical methyltransferase PCMT PF01135.14 EWC47840.1 - 0.029 13.8 0.0 0.055 13.0 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_32 PF13679.1 EWC47840.1 - 0.24 11.1 0.0 0.48 10.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain NmrA PF05368.8 EWC47841.1 - 3.1e-26 92.0 0.1 4e-26 91.7 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 EWC47841.1 - 5.5e-11 42.8 1.2 3.6e-10 40.1 0.2 2.0 1 1 1 2 2 2 1 NADH(P)-binding Semialdhyde_dh PF01118.19 EWC47841.1 - 0.00034 20.9 0.2 0.00079 19.7 0.1 1.6 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Epimerase PF01370.16 EWC47841.1 - 0.0022 17.4 0.0 0.0039 16.6 0.0 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DapB_N PF01113.15 EWC47841.1 - 0.0033 17.3 0.1 0.018 14.9 0.0 2.3 2 1 1 3 3 3 1 Dihydrodipicolinate reductase, N-terminus 3Beta_HSD PF01073.14 EWC47841.1 - 0.028 13.1 0.0 0.17 10.5 0.0 2.2 2 1 0 2 2 2 0 3-beta hydroxysteroid dehydrogenase/isomerase family DUF3646 PF12362.3 EWC47841.1 - 0.1 12.5 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 DNA polymerase III gamma and tau subunits C terminal MFS_1 PF07690.11 EWC47842.1 - 6e-24 84.4 37.6 2.5e-18 65.9 7.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EWC47842.1 - 1.8e-07 30.0 0.9 1.8e-07 30.0 0.6 2.2 2 0 0 2 2 2 1 Sugar (and other) transporter DUF2463 PF09591.5 EWC47842.1 - 0.00091 18.8 2.3 0.03 13.9 0.6 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF2463) MFS_3 PF05977.8 EWC47842.1 - 0.25 9.4 0.0 0.25 9.4 0.0 3.0 3 0 0 3 3 3 0 Transmembrane secretion effector CD47 PF04549.9 EWC47842.1 - 0.6 10.0 6.0 0.21 11.5 0.9 2.2 1 1 1 2 2 2 0 CD47 transmembrane region Adeno_E3_CR2 PF02439.10 EWC47843.1 - 0.089 12.3 0.7 0.15 11.6 0.5 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 DUF3431 PF11913.3 EWC47844.1 - 6.4e-10 38.8 0.0 7.9e-10 38.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3431) DUF2236 PF09995.4 EWC47845.1 - 1.8e-10 40.5 0.0 3.1e-10 39.7 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2236) DAO PF01266.19 EWC47846.1 - 4.5e-46 157.3 1.3 8.1e-46 156.5 0.9 1.4 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 EWC47846.1 - 2.4e-05 24.2 1.5 0.39 10.5 0.0 3.0 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 EWC47846.1 - 4.9e-05 23.2 0.3 9.6e-05 22.3 0.2 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.22 EWC47846.1 - 0.00049 20.4 0.2 0.0017 18.7 0.1 1.9 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 EWC47846.1 - 0.00057 18.8 2.5 0.0067 15.3 0.1 2.2 2 0 0 2 2 2 1 Glucose inhibited division protein A Lycopene_cycl PF05834.7 EWC47846.1 - 0.0008 18.4 0.8 0.63 8.8 0.1 2.1 2 0 0 2 2 2 2 Lycopene cyclase protein Thi4 PF01946.12 EWC47846.1 - 0.0011 18.1 1.6 0.013 14.6 0.2 2.3 2 0 0 2 2 2 1 Thi4 family FAD_binding_2 PF00890.19 EWC47846.1 - 0.0048 15.7 2.2 0.017 13.9 0.4 2.0 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_3 PF13738.1 EWC47846.1 - 0.0066 16.5 0.2 0.5 10.4 0.0 2.3 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 EWC47846.1 - 0.0079 15.9 0.1 1 9.0 0.0 2.4 2 0 0 2 2 2 1 FAD-NAD(P)-binding GMC_oxred_N PF00732.14 EWC47846.1 - 0.014 14.5 0.6 1.3 8.0 0.0 2.2 2 0 0 2 2 2 0 GMC oxidoreductase FAD_binding_3 PF01494.14 EWC47846.1 - 0.028 13.4 0.8 0.064 12.2 0.5 1.5 1 0 0 1 1 1 0 FAD binding domain Trp_halogenase PF04820.9 EWC47846.1 - 0.087 11.4 1.2 0.14 10.8 0.8 1.2 1 0 0 1 1 1 0 Tryptophan halogenase DUF2181 PF10223.4 EWC47846.1 - 0.12 11.6 0.0 4.6 6.5 0.0 2.1 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2181) MFS_1 PF07690.11 EWC47848.1 - 1.3e-07 30.7 19.3 1.5e-06 27.1 11.2 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 EWC47848.1 - 0.038 12.3 14.8 0.074 11.4 6.2 2.0 2 0 0 2 2 2 0 MFS/sugar transport protein ORC6 PF05460.8 EWC47848.1 - 8 5.4 13.0 0.82 8.7 5.2 1.8 2 0 0 2 2 2 0 Origin recognition complex subunit 6 (ORC6) zf-C2H2_4 PF13894.1 EWC47850.1 - 7.7e-05 22.7 16.0 0.066 13.5 0.0 4.6 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_6 PF13912.1 EWC47850.1 - 0.0048 16.7 4.3 1.2 9.1 0.5 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.21 EWC47850.1 - 0.014 15.7 16.9 0.57 10.6 0.1 4.8 4 0 0 4 4 4 0 Zinc finger, C2H2 type zf-met PF12874.2 EWC47850.1 - 0.18 12.0 4.6 4.9 7.4 0.5 3.7 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 EWC47850.1 - 0.82 9.8 7.6 18 5.6 0.5 3.5 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding Striatin PF08232.7 EWC47851.1 - 2.4 8.4 8.9 0.39 11.0 3.2 1.8 2 0 0 2 2 2 0 Striatin family EPL1 PF10513.4 EWC47852.1 - 7.7e-17 61.9 3.6 2.3e-16 60.4 2.5 1.9 1 1 0 1 1 1 1 Enhancer of polycomb-like PHD PF00628.24 EWC47852.1 - 0.0019 17.8 3.6 0.0034 17.0 2.5 1.4 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.1 EWC47852.1 - 0.0022 17.2 0.2 0.0022 17.2 0.1 1.7 2 0 0 2 2 2 1 PHD-finger zf-CpG_bind_C PF12269.3 EWC47852.1 - 0.055 12.9 0.5 0.083 12.3 0.3 1.2 1 0 0 1 1 1 0 CpG binding protein zinc finger C terminal domain zf-HC5HC2H PF13771.1 EWC47853.1 - 4.7e-28 97.1 1.8 9.4e-28 96.2 1.3 1.5 1 0 0 1 1 1 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.1 EWC47853.1 - 5.4e-27 93.9 1.6 1.1e-26 93.0 1.1 1.5 1 0 0 1 1 1 1 PHD-zinc-finger like domain zf-RING-like PF08746.6 EWC47853.1 - 0.009 15.9 5.5 0.016 15.1 3.8 1.4 1 0 0 1 1 1 1 RING-like domain zf-C2H2_4 PF13894.1 EWC47854.1 - 2.5e-07 30.5 11.7 0.00082 19.5 1.5 4.0 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2 PF00096.21 EWC47854.1 - 3.5e-06 27.0 10.9 0.11 12.8 1.0 4.0 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 EWC47854.1 - 0.002 18.3 11.8 0.18 12.1 0.3 4.7 4 0 0 4 4 4 3 Zinc-finger double domain zf-Di19 PF05605.7 EWC47854.1 - 0.74 9.9 10.8 0.36 10.9 0.6 3.6 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding CMD PF02627.15 EWC47857.1 - 0.069 12.9 0.6 0.26 11.1 0.0 2.3 2 0 0 2 2 2 0 Carboxymuconolactone decarboxylase family F_actin_bind PF08919.5 EWC47857.1 - 0.28 10.8 4.6 0.47 10.1 0.9 2.9 3 1 1 4 4 4 0 F-actin binding Wx5_PLAF3D7 PF09688.5 EWC47857.1 - 0.85 9.5 5.6 1.5 8.7 0.9 2.9 3 0 0 3 3 3 0 Protein of unknown function (Wx5_PLAF3D7) Cob_adeno_trans PF01923.13 EWC47857.1 - 1.9 8.2 6.2 3.3 7.4 0.2 2.7 3 0 0 3 3 3 0 Cobalamin adenosyltransferase zf-rbx1 PF12678.2 EWC47858.1 - 4.2e-10 39.6 1.4 1.2e-09 38.1 1.0 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_2 PF13639.1 EWC47858.1 - 4.6e-10 39.1 4.3 8.6e-10 38.2 1.1 2.4 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.1 EWC47858.1 - 7.9e-07 28.6 5.9 5e-06 26.0 2.1 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EWC47858.1 - 2.4e-06 27.0 0.6 6.2e-06 25.7 0.4 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 EWC47858.1 - 3.8e-05 23.6 2.2 3.8e-05 23.6 1.5 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EWC47858.1 - 8e-05 22.2 4.0 0.00062 19.4 3.1 2.2 1 1 1 2 2 2 1 zinc-RING finger domain zf-RING_4 PF14570.1 EWC47858.1 - 0.0023 17.4 0.5 0.0023 17.4 0.3 1.7 2 0 0 2 2 2 1 RING/Ubox like zinc-binding domain zf-RING_UBOX PF13445.1 EWC47858.1 - 0.0065 16.1 2.7 0.024 14.3 1.9 2.0 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.1 EWC47858.1 - 0.031 14.1 1.3 0.066 13.0 0.9 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING SHOCT PF09851.4 EWC47858.1 - 0.092 12.2 0.9 0.17 11.3 0.3 1.7 2 0 0 2 2 2 0 Short C-terminal domain zf-Apc11 PF12861.2 EWC47858.1 - 0.3 10.9 5.8 2.9 7.8 4.0 2.4 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger RRM_1 PF00076.17 EWC47859.1 - 1.8e-20 72.3 0.0 2.7e-20 71.7 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EWC47859.1 - 1.2e-13 50.8 0.0 1.7e-13 50.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EWC47859.1 - 3e-08 33.3 0.0 4.2e-08 32.9 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-LITAF-like PF10601.4 EWC47860.1 - 0.39 10.6 0.0 0.39 10.6 0.0 2.9 4 0 0 4 4 4 0 LITAF-like zinc ribbon domain Sporozoite_P67 PF05642.6 EWC47860.1 - 4.8 4.9 7.9 6.7 4.4 5.5 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Peptidase_S8 PF00082.17 EWC47862.1 - 6.5e-42 143.6 3.9 1e-41 142.9 2.7 1.2 1 0 0 1 1 1 1 Subtilase family Peptidase_M22 PF00814.20 EWC47863.1 - 1.6e-10 40.9 0.0 1.9e-10 40.6 0.0 1.1 1 0 0 1 1 1 1 Glycoprotease family FGGY_C PF02782.11 EWC47863.1 - 0.03 13.9 0.0 0.05 13.2 0.0 1.3 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain Myb_DNA-binding PF00249.26 EWC47864.1 - 9.2e-23 80.0 0.8 1.3e-10 41.0 0.0 2.8 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 EWC47864.1 - 6.9e-16 58.0 0.1 4.7e-11 42.6 0.0 2.6 1 1 1 2 2 2 2 Myb-like DNA-binding domain Glyco_transf_41 PF13844.1 EWC47865.1 - 2.1e-92 309.5 0.0 2.2e-45 154.5 0.0 3.4 3 1 0 4 4 4 2 Glycosyl transferase family 41 TPR_11 PF13414.1 EWC47865.1 - 3e-23 81.2 3.7 1.3e-07 31.1 0.0 4.4 4 0 0 4 4 4 3 TPR repeat TPR_1 PF00515.23 EWC47865.1 - 3.8e-20 70.5 1.7 0.00016 21.1 0.0 5.6 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.12 EWC47865.1 - 2.8e-19 67.4 0.9 0.00064 19.4 0.0 5.7 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_12 PF13424.1 EWC47865.1 - 7.3e-14 51.4 2.6 2e-07 30.8 0.1 4.5 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.1 EWC47865.1 - 1.6e-13 50.9 6.1 5.4e-06 26.9 0.0 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.1 EWC47865.1 - 3.2e-13 48.7 2.2 0.018 15.1 0.0 5.2 5 0 0 5 5 4 4 Tetratricopeptide repeat TPR_8 PF13181.1 EWC47865.1 - 9.4e-13 46.9 0.1 0.00087 18.9 0.0 4.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.1 EWC47865.1 - 9.5e-13 47.5 1.6 0.001 19.5 0.1 5.3 3 2 2 5 5 4 3 Tetratricopeptide repeat TPR_7 PF13176.1 EWC47865.1 - 1.3e-08 34.0 2.3 0.11 12.3 0.0 4.6 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.1 EWC47865.1 - 3.2e-08 33.8 1.1 0.0061 16.8 0.0 3.5 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.1 EWC47865.1 - 9e-07 28.6 8.0 0.056 13.3 0.0 5.3 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_6 PF13174.1 EWC47865.1 - 8.5e-06 25.9 0.4 4.8 7.8 0.0 5.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_9 PF13371.1 EWC47865.1 - 0.011 15.5 0.2 0.1 12.4 0.1 2.7 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_15 PF13429.1 EWC47865.1 - 0.037 13.0 0.0 0.11 11.5 0.0 1.7 2 0 0 2 2 2 0 Tetratricopeptide repeat Mito_carr PF00153.22 EWC47866.1 - 9.2e-72 236.8 2.0 4.2e-25 87.2 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_1 PF00036.27 EWC47866.1 - 3.4e-11 41.6 0.2 0.002 17.2 0.0 5.5 5 0 0 5 5 5 2 EF hand EF-hand_7 PF13499.1 EWC47866.1 - 1.1e-10 41.5 2.0 0.00028 20.9 0.1 4.0 2 2 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.1 EWC47866.1 - 1.5e-10 40.0 0.3 0.00077 19.1 0.0 5.8 7 0 0 7 7 7 2 EF-hand domain EF-hand_8 PF13833.1 EWC47866.1 - 4.2e-09 35.8 0.1 0.02 14.4 0.0 4.4 4 0 0 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.1 EWC47866.1 - 0.011 15.0 0.4 35 3.9 0.0 4.6 5 0 0 5 5 5 0 EF hand EF-hand_9 PF14658.1 EWC47866.1 - 0.021 14.7 0.0 8.7 6.3 0.0 3.8 4 0 0 4 4 4 0 EF-hand domain RPN7 PF10602.4 EWC47867.1 - 2.1e-48 164.0 0.6 3.7e-48 163.2 0.4 1.4 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.22 EWC47867.1 - 5e-20 71.7 0.2 4e-19 68.8 0.0 2.4 3 0 0 3 3 3 1 PCI domain Foie-gras_1 PF11817.3 EWC47867.1 - 0.097 12.1 0.3 0.2 11.1 0.0 1.6 2 0 0 2 2 2 0 Foie gras liver health family 1 TPR_2 PF07719.12 EWC47867.1 - 2.8 8.0 7.5 20 5.3 0.0 4.1 5 0 0 5 5 5 0 Tetratricopeptide repeat Glucodextran_B PF09136.5 EWC47868.1 - 0.097 12.8 4.7 0.78 9.9 0.0 3.1 3 0 0 3 3 3 0 Glucodextranase, domain B PQ-loop PF04193.9 EWC47869.1 - 1.4e-23 82.1 22.2 2.5e-13 49.3 0.8 2.7 3 0 0 3 3 3 2 PQ loop repeat DUF3040 PF11239.3 EWC47869.1 - 1.7 8.7 4.0 43 4.2 0.0 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF3040) SET PF00856.23 EWC47870.1 - 3e-15 56.9 0.0 7.3e-15 55.6 0.0 1.7 1 0 0 1 1 1 1 SET domain HTH_32 PF13565.1 EWC47871.1 - 0.039 14.7 0.6 0.24 12.1 0.3 2.5 2 1 0 2 2 2 0 Homeodomain-like domain Myb_DNA-bind_3 PF12776.2 EWC47872.1 - 0.12 12.9 1.8 4 8.1 0.1 2.5 1 1 1 2 2 2 0 Myb/SANT-like DNA-binding domain IQ PF00612.22 EWC47873.1 - 1.5e-05 24.2 11.8 0.0024 17.3 0.3 3.8 3 0 0 3 3 3 3 IQ calmodulin-binding motif CH PF00307.26 EWC47873.1 - 2.6e-05 24.2 0.0 0.00012 22.0 0.0 2.1 2 0 0 2 2 2 1 Calponin homology (CH) domain AAA PF00004.24 EWC47874.1 - 3.5e-52 176.1 0.0 1.5e-43 148.1 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 EWC47874.1 - 8e-07 29.2 0.0 3.8e-05 23.7 0.0 2.9 2 0 0 2 2 2 1 AAA ATPase domain AAA_2 PF07724.9 EWC47874.1 - 2.3e-06 27.6 0.0 6.1e-06 26.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.12 EWC47874.1 - 2e-05 24.1 0.0 0.00018 21.0 0.0 2.2 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_22 PF13401.1 EWC47874.1 - 3.7e-05 23.8 0.0 0.00076 19.6 0.0 3.0 2 1 0 2 2 2 1 AAA domain Sigma54_activ_2 PF14532.1 EWC47874.1 - 6.2e-05 23.0 0.0 0.082 12.9 0.0 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_5 PF07728.9 EWC47874.1 - 0.00023 20.8 0.0 0.00085 19.0 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.1 EWC47874.1 - 0.0012 19.1 0.1 0.014 15.7 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 EWC47874.1 - 0.0018 19.0 0.0 0.013 16.3 0.0 2.6 2 0 0 2 2 1 1 AAA domain AAA_33 PF13671.1 EWC47874.1 - 0.0027 17.5 0.0 0.011 15.6 0.0 2.1 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.17 EWC47874.1 - 0.0031 17.6 0.0 0.012 15.7 0.0 2.1 1 0 0 1 1 1 1 RNA helicase AAA_19 PF13245.1 EWC47874.1 - 0.0034 17.0 0.1 0.016 14.9 0.1 2.1 2 0 0 2 2 2 1 Part of AAA domain TIP49 PF06068.8 EWC47874.1 - 0.0062 15.3 0.0 0.012 14.3 0.0 1.4 1 0 0 1 1 1 1 TIP49 C-terminus ABC_tran PF00005.22 EWC47874.1 - 0.0067 16.7 0.5 0.062 13.5 0.0 2.9 3 0 0 3 3 3 1 ABC transporter AAA_14 PF13173.1 EWC47874.1 - 0.014 15.2 0.0 0.036 13.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.21 EWC47874.1 - 0.023 14.1 0.0 1.2 8.5 0.0 2.6 3 0 0 3 3 3 0 Sigma-54 interaction domain RuvB_N PF05496.7 EWC47874.1 - 0.028 13.4 0.0 0.074 12.0 0.0 1.7 2 0 0 2 2 2 0 Holliday junction DNA helicase ruvB N-terminus Mg_chelatase PF01078.16 EWC47874.1 - 0.045 12.9 0.0 0.12 11.5 0.0 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_25 PF13481.1 EWC47874.1 - 0.062 12.6 1.5 0.15 11.4 0.1 2.4 2 1 0 2 2 2 0 AAA domain Torsin PF06309.6 EWC47874.1 - 0.15 11.9 0.0 1.4 8.8 0.0 2.1 2 0 0 2 2 2 0 Torsin NACHT PF05729.7 EWC47874.1 - 0.19 11.3 0.5 0.58 9.7 0.0 2.1 2 1 0 2 2 2 0 NACHT domain Stm1_N PF09598.5 EWC47875.1 - 0.023 15.3 0.4 0.043 14.5 0.3 1.5 1 0 0 1 1 1 0 Stm1 Glyco_hydro_45 PF02015.11 EWC47877.1 - 4.6e-48 163.9 8.5 5.7e-48 163.6 5.9 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 45 Metallophos PF00149.23 EWC47879.1 - 0.00012 21.5 2.0 0.00058 19.3 1.4 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Glyco_hydro_76 PF03663.9 EWC47880.1 - 6e-19 68.6 0.6 4.2e-13 49.4 0.0 2.1 2 0 0 2 2 2 2 Glycosyl hydrolase family 76 zf-PHD-like PF15446.1 EWC47882.1 - 0.036 13.3 0.2 0.069 12.4 0.0 1.5 2 0 0 2 2 2 0 PHD/FYVE-zinc-finger like domain Tfb4 PF03850.9 EWC47883.1 - 5.3e-94 314.5 0.0 6.2e-94 314.3 0.0 1.0 1 0 0 1 1 1 1 Transcription factor Tfb4 VWA_2 PF13519.1 EWC47883.1 - 0.026 14.6 0.1 0.044 13.8 0.0 1.5 1 1 0 1 1 1 0 von Willebrand factor type A domain Asparaginase_2 PF01112.13 EWC47884.1 - 9.2e-42 142.8 0.2 3e-41 141.1 0.1 1.7 1 1 0 1 1 1 1 Asparaginase Actin PF00022.14 EWC47885.1 - 3.3e-90 302.3 0.0 7.6e-90 301.1 0.0 1.5 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.8 EWC47885.1 - 0.012 14.2 0.0 0.56 8.7 0.0 2.2 2 0 0 2 2 2 0 MreB/Mbl protein CM_2 PF01817.16 EWC47887.1 - 3.6e-09 36.5 0.0 1e-05 25.5 0.0 3.2 2 1 0 2 2 2 2 Chorismate mutase type II zf-ZPR1 PF03367.8 EWC47888.1 - 7.4e-112 369.8 0.1 4.2e-57 191.8 0.0 2.1 2 0 0 2 2 2 2 ZPR1 zinc-finger domain Cytochrome_C554 PF13435.1 EWC47888.1 - 0.071 13.1 2.4 0.2 11.6 0.3 2.4 2 1 0 2 2 2 0 Cytochrome c554 and c-prime Haem_bd PF14376.1 EWC47888.1 - 0.072 12.7 0.7 1.9 8.1 0.0 2.5 1 1 1 2 2 2 0 Haem-binding domain HypA PF01155.14 EWC47888.1 - 0.11 12.2 2.2 6.7 6.4 0.1 2.7 2 1 0 2 2 2 0 Hydrogenase expression/synthesis hypA family zinc-ribbons_6 PF07191.7 EWC47888.1 - 0.12 12.1 1.7 1.1 9.0 0.0 2.8 3 0 0 3 3 3 0 zinc-ribbons Lar_restr_allev PF14354.1 EWC47888.1 - 0.27 11.5 5.0 1.5 9.2 0.2 3.2 3 0 0 3 3 3 0 Restriction alleviation protein Lar UPF0547 PF10571.4 EWC47888.1 - 2.4 7.9 8.7 0.67 9.7 0.1 2.8 3 0 0 3 3 3 0 Uncharacterised protein family UPF0547 Ribosomal_L32p PF01783.18 EWC47888.1 - 2.5 8.3 5.8 0.95 9.6 0.2 3.0 4 0 0 4 4 4 0 Ribosomal L32p protein family Elf1 PF05129.8 EWC47888.1 - 3.8 7.2 7.4 9.4 6.0 0.4 2.7 3 0 0 3 3 3 0 Transcription elongation factor Elf1 like Auto_anti-p27 PF06677.7 EWC47888.1 - 5.4 6.8 0.0 5.4 6.8 0.0 3.8 5 0 0 5 5 5 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) F-box PF00646.28 EWC47889.1 - 0.016 14.8 0.5 0.051 13.2 0.0 2.1 2 0 0 2 2 2 0 F-box domain Peptidase_S32 PF05579.8 EWC47890.1 - 0.016 14.1 0.0 2.3 7.1 0.0 2.2 2 0 0 2 2 2 0 Equine arteritis virus serine endopeptidase S32 Peptidase_S64 PF08192.6 EWC47890.1 - 0.13 10.5 0.4 1.6 7.0 0.0 2.3 3 0 0 3 3 3 0 Peptidase family S64 zf-RING_2 PF13639.1 EWC47891.1 - 0.00016 21.3 7.9 0.00016 21.3 5.5 3.3 2 1 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.1 EWC47891.1 - 0.0022 17.9 7.3 0.0022 17.9 5.0 4.0 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) IBR PF01485.16 EWC47891.1 - 0.01 15.7 29.4 0.011 15.5 3.7 3.6 2 2 0 3 3 3 2 IBR domain zf-RING_UBOX PF13445.1 EWC47891.1 - 0.017 14.8 1.7 0.056 13.1 1.2 1.9 1 0 0 1 1 1 0 RING-type zinc-finger FYVE PF01363.16 EWC47891.1 - 0.017 14.9 3.5 0.017 14.9 2.4 3.5 2 1 1 3 3 3 0 FYVE zinc finger Zn_Tnp_IS91 PF14319.1 EWC47891.1 - 9.4 5.7 22.0 0.93 9.0 1.2 3.6 3 0 0 3 3 3 0 Transposase zinc-binding domain HET PF06985.6 EWC47892.1 - 6.3e-14 52.3 1.9 1.1e-12 48.3 0.0 2.4 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) FbpA PF05833.6 EWC47893.1 - 0.11 10.9 1.0 0.24 9.9 0.7 1.6 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) Glypican PF01153.14 EWC47893.1 - 0.35 9.4 2.7 0.51 8.8 1.9 1.1 1 0 0 1 1 1 0 Glypican zf-C3HC4_2 PF13923.1 EWC47894.1 - 0.0006 19.7 7.8 0.00096 19.1 5.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EWC47894.1 - 0.0086 15.7 7.8 0.016 14.8 5.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 EWC47894.1 - 0.011 15.3 6.3 0.017 14.7 4.4 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EWC47894.1 - 0.025 14.3 8.3 0.042 13.6 5.8 1.5 1 1 0 1 1 1 0 Ring finger domain zf-RING_5 PF14634.1 EWC47894.1 - 0.039 13.6 8.0 0.12 12.1 5.7 1.7 1 1 0 1 1 1 0 zinc-RING finger domain YdjO PF14169.1 EWC47894.1 - 0.19 11.2 3.8 0.61 9.5 0.1 2.4 1 1 1 2 2 2 0 Cold-inducible protein YdjO zf-C3HC4_4 PF15227.1 EWC47894.1 - 2.6 7.9 8.2 0.72 9.7 2.8 2.1 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING GFA PF04828.9 EWC47895.1 - 6.6e-18 64.4 5.9 7.6e-10 38.6 0.4 3.1 4 0 0 4 4 4 2 Glutathione-dependent formaldehyde-activating enzyme Pkr1 PF08636.5 EWC47896.1 - 0.0087 16.0 1.4 0.0087 16.0 1.0 2.9 3 0 0 3 3 3 1 ER protein Pkr1 PalH PF08733.5 EWC47896.1 - 0.086 11.6 8.1 0.12 11.2 5.6 1.1 1 0 0 1 1 1 0 PalH/RIM21 FtsX PF02687.16 EWC47896.1 - 0.37 10.5 14.6 1.1 8.9 2.1 2.4 2 0 0 2 2 2 0 FtsX-like permease family TrbC PF04956.8 EWC47896.1 - 1.3 9.1 11.5 4.6 7.3 2.7 2.5 1 1 1 2 2 2 0 TrbC/VIRB2 family Peptidase_U4 PF03419.8 EWC47896.1 - 3 6.8 8.6 1.1 8.2 4.0 1.6 1 1 0 1 1 1 0 Sporulation factor SpoIIGA E1-E2_ATPase PF00122.15 EWC47896.1 - 7.5 5.5 6.2 4.3 6.2 2.7 1.8 2 0 0 2 2 2 0 E1-E2 ATPase Herpes_env PF01673.13 EWC47897.1 - 7.1 5.0 8.2 11 4.4 5.7 1.2 1 0 0 1 1 1 0 Herpesvirus putative major envelope glycoprotein DUF1399 PF07173.7 EWC47897.1 - 7.2 6.9 10.6 4.7 7.5 0.0 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF1399) IL13 PF03487.8 EWC47898.1 - 0.028 14.1 0.1 1.2 8.8 0.0 2.4 2 0 0 2 2 2 0 Interleukin-13 Met_10 PF02475.11 EWC47899.1 - 0.00021 20.9 0.0 0.00034 20.2 0.0 1.4 1 0 0 1 1 1 1 Met-10+ like-protein EF-hand_6 PF13405.1 EWC47900.1 - 1.1e-06 28.0 2.5 0.00088 18.9 0.0 3.0 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.1 EWC47900.1 - 2.5e-05 23.4 0.0 5.8e-05 22.2 0.0 1.6 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.27 EWC47900.1 - 3.5e-05 22.7 0.1 8.7e-05 21.5 0.0 1.7 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.1 EWC47900.1 - 0.0002 20.8 0.0 0.00042 19.8 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_7 PF13499.1 EWC47900.1 - 0.00037 20.5 1.2 0.0017 18.4 0.8 2.2 1 1 0 1 1 1 1 EF-hand domain pair ubiquitin PF00240.18 EWC47901.1 - 4.4e-07 29.1 0.1 5.4e-07 28.9 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.1 EWC47901.1 - 0.0055 16.9 0.0 0.031 14.5 0.0 1.9 1 1 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD PF11976.3 EWC47901.1 - 0.0095 15.6 0.1 0.015 14.9 0.1 1.4 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Clp1 PF06807.9 EWC47902.1 - 8.7e-20 71.3 0.0 1.9e-19 70.1 0.0 1.5 1 1 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 MobB PF03205.9 EWC47902.1 - 1.8e-10 40.6 0.0 3.1e-10 39.8 0.0 1.4 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B ATP_bind_1 PF03029.12 EWC47902.1 - 0.0036 16.8 0.0 0.0062 16.1 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein PduV-EutP PF10662.4 EWC47902.1 - 0.0092 15.4 0.0 0.016 14.7 0.0 1.3 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation AAA_10 PF12846.2 EWC47902.1 - 0.018 14.4 0.1 0.031 13.7 0.1 1.4 1 0 0 1 1 1 0 AAA-like domain AAA PF00004.24 EWC47902.1 - 0.022 14.9 0.1 0.042 14.0 0.1 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.1 EWC47902.1 - 0.026 14.2 0.4 0.068 12.9 0.3 1.7 1 0 0 1 1 1 0 Part of AAA domain SRP54 PF00448.17 EWC47902.1 - 0.033 13.6 0.0 0.056 12.8 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain ABC_tran PF00005.22 EWC47902.1 - 0.043 14.1 0.0 0.08 13.2 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_24 PF13479.1 EWC47902.1 - 0.1 12.1 0.0 0.17 11.4 0.0 1.2 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.18 EWC47902.1 - 0.12 12.3 0.0 0.32 10.9 0.0 1.9 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_17 PF13207.1 EWC47902.1 - 0.13 13.0 0.1 0.33 11.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain DBR1 PF05011.8 EWC47903.1 - 4e-30 104.6 0.0 6.5e-30 103.9 0.0 1.3 1 0 0 1 1 1 1 Lariat debranching enzyme, C-terminal domain Metallophos PF00149.23 EWC47903.1 - 1.6e-09 37.4 0.0 2.4e-09 36.8 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 EWC47903.1 - 0.0011 18.7 0.0 0.002 18.0 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain IL11 PF07400.6 EWC47903.1 - 0.038 13.5 0.0 0.1 12.1 0.0 1.6 1 0 0 1 1 1 0 Interleukin 11 UNC45-central PF11701.3 EWC47904.1 - 3.8e-21 75.3 0.3 7.1e-20 71.2 0.0 3.3 3 1 0 3 3 3 1 Myosin-binding striated muscle assembly central Arm PF00514.18 EWC47904.1 - 3e-07 30.0 15.3 0.0065 16.2 0.0 7.3 9 0 0 9 9 9 2 Armadillo/beta-catenin-like repeat TPR_11 PF13414.1 EWC47904.1 - 0.00024 20.6 0.1 0.00098 18.7 0.1 2.1 1 0 0 1 1 1 1 TPR repeat TPR_2 PF07719.12 EWC47904.1 - 0.0044 16.8 0.3 0.0044 16.8 0.2 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.1 EWC47904.1 - 0.0055 17.2 2.1 0.0055 17.2 1.4 4.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.1 EWC47904.1 - 0.02 15.5 0.5 0.02 15.5 0.3 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.1 EWC47904.1 - 0.18 12.1 0.2 0.18 12.1 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat RNA_pol_Rpb8 PF03870.10 EWC47905.1 - 2.5e-32 111.9 0.1 2.9e-32 111.7 0.1 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 NUDIX PF00293.23 EWC47906.1 - 0.0036 16.9 0.0 0.0087 15.6 0.0 1.7 1 1 0 1 1 1 1 NUDIX domain MoCF_biosynth PF00994.19 EWC47907.1 - 2.1e-60 202.2 1.1 1.3e-31 108.9 0.1 2.5 2 0 0 2 2 2 2 Probable molybdopterin binding domain MoeA_N PF03453.12 EWC47907.1 - 3.5e-35 120.7 4.5 5.6e-35 120.0 3.2 1.3 1 0 0 1 1 1 1 MoeA N-terminal region (domain I and II) MoeA_C PF03454.10 EWC47907.1 - 5.1e-11 42.3 0.2 1.6e-10 40.7 0.0 1.9 2 0 0 2 2 2 1 MoeA C-terminal region (domain IV) MAS20 PF02064.10 EWC47908.1 - 3.8e-23 81.6 1.2 9.6e-23 80.3 0.8 1.6 1 1 0 1 1 1 1 MAS20 protein import receptor HlyD PF00529.15 EWC47908.1 - 0.33 10.2 4.9 0.48 9.6 3.4 1.1 1 0 0 1 1 1 0 HlyD family secretion protein WD40 PF00400.27 EWC47909.1 - 1.2e-17 63.0 10.3 1.8e-05 24.4 0.0 6.0 6 0 0 6 6 6 5 WD domain, G-beta repeat HYLS1_C PF15311.1 EWC47910.1 - 0.08 13.1 0.1 0.22 11.7 0.1 1.7 1 0 0 1 1 1 0 Hydrolethalus syndrome protein 1 C-terminus Trypsin_2 PF13365.1 EWC47911.1 - 1.9e-15 56.8 0.0 3.3e-15 56.1 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain Peptidase_S46 PF10459.4 EWC47911.1 - 0.00054 18.5 0.0 0.00095 17.7 0.0 1.4 1 0 0 1 1 1 1 Peptidase S46 OTU PF02338.14 EWC47912.1 - 1e-15 58.3 0.8 1.8e-15 57.5 0.0 1.8 2 1 0 2 2 2 1 OTU-like cysteine protease MIP-T3 PF10243.4 EWC47912.1 - 0.0014 17.2 21.4 0.002 16.6 14.8 1.2 1 0 0 1 1 1 1 Microtubule-binding protein MIP-T3 DUF572 PF04502.8 EWC47912.1 - 0.036 13.2 13.4 0.056 12.6 9.3 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) UBA_4 PF14555.1 EWC47912.1 - 0.042 13.4 0.0 0.079 12.5 0.0 1.4 1 0 0 1 1 1 0 UBA-like domain Peptidase_C65 PF10275.4 EWC47912.1 - 0.046 13.0 0.7 7.2 5.8 0.0 2.6 1 1 1 2 2 2 0 Peptidase C65 Otubain PIH1 PF08190.7 EWC47912.1 - 0.077 12.4 6.9 0.1 12.0 3.9 1.9 2 0 0 2 2 2 0 pre-RNA processing PIH1/Nop17 CotE PF10628.4 EWC47912.1 - 0.18 11.1 2.7 0.32 10.3 1.9 1.3 1 0 0 1 1 1 0 Outer spore coat protein E (CotE) TATR PF03430.8 EWC47912.1 - 3.1 6.3 7.6 4.4 5.8 5.3 1.1 1 0 0 1 1 1 0 Trans-activating transcriptional regulator Thioredoxin PF00085.15 EWC47913.1 - 1.8e-26 91.8 0.2 2.4e-26 91.4 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.1 EWC47913.1 - 6.2e-06 26.3 0.2 7.1e-05 22.9 0.1 2.1 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_9 PF14595.1 EWC47913.1 - 2.7e-05 23.7 0.0 3.6e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.1 EWC47913.1 - 5.2e-05 23.2 0.0 0.00014 21.9 0.0 1.7 1 1 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.16 EWC47913.1 - 0.0043 16.7 0.0 0.0063 16.1 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 EWC47913.1 - 0.013 15.0 0.1 0.17 11.4 0.1 2.0 1 1 1 2 2 2 0 Redoxin Glutaredoxin PF00462.19 EWC47913.1 - 0.016 15.2 0.2 0.025 14.5 0.1 1.4 1 0 0 1 1 1 0 Glutaredoxin Phosducin PF02114.11 EWC47913.1 - 0.1 11.2 0.0 0.11 11.1 0.0 1.1 1 0 0 1 1 1 0 Phosducin Thioredoxin_7 PF13899.1 EWC47913.1 - 0.16 11.9 0.2 0.29 11.1 0.1 1.5 1 1 0 1 1 1 0 Thioredoxin-like DAO PF01266.19 EWC47916.1 - 8.9e-30 103.7 0.4 1e-29 103.6 0.3 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EWC47916.1 - 6.4e-06 26.0 0.7 3.1e-05 23.8 0.1 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 EWC47916.1 - 3.8e-05 22.7 0.0 5e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.9 EWC47916.1 - 0.00012 21.9 0.0 0.0002 21.3 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 EWC47916.1 - 0.00047 20.5 0.6 0.0012 19.1 0.4 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 EWC47916.1 - 0.00077 18.6 0.6 0.0039 16.3 0.0 2.3 2 1 1 3 3 3 1 Thi4 family NAD_binding_7 PF13241.1 EWC47916.1 - 0.0012 19.0 0.0 0.0021 18.2 0.0 1.5 1 0 0 1 1 1 1 Putative NAD(P)-binding Trp_halogenase PF04820.9 EWC47916.1 - 0.0013 17.4 0.4 0.039 12.5 0.1 2.1 2 0 0 2 2 2 1 Tryptophan halogenase UDPG_MGDP_dh_N PF03721.9 EWC47916.1 - 0.0014 18.0 0.5 0.0025 17.2 0.3 1.4 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain GIDA PF01134.17 EWC47916.1 - 0.0058 15.5 0.3 0.0097 14.8 0.2 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A FAD_binding_3 PF01494.14 EWC47916.1 - 0.0058 15.7 0.2 0.0096 15.0 0.2 1.3 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.9 EWC47916.1 - 0.006 15.0 0.5 0.0097 14.4 0.3 1.3 1 0 0 1 1 1 1 HI0933-like protein ApbA PF02558.11 EWC47916.1 - 0.025 14.0 0.2 0.054 12.9 0.1 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA NAD_Gly3P_dh_N PF01210.18 EWC47916.1 - 0.033 13.9 0.0 0.06 13.0 0.0 1.4 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus AlaDh_PNT_C PF01262.16 EWC47916.1 - 0.041 13.4 0.3 0.065 12.7 0.2 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain 3HCDH_N PF02737.13 EWC47916.1 - 0.044 13.4 0.6 0.08 12.5 0.4 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Lycopene_cycl PF05834.7 EWC47916.1 - 0.077 11.9 0.1 0.29 10.0 0.0 1.8 2 0 0 2 2 2 0 Lycopene cyclase protein NAD_binding_10 PF13460.1 EWC47916.1 - 0.11 12.5 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 NADH(P)-binding TPR_11 PF13414.1 EWC47917.1 - 4.8e-07 29.3 0.5 0.00019 20.9 0.1 3.0 2 0 0 2 2 2 1 TPR repeat TPR_12 PF13424.1 EWC47917.1 - 6.3e-05 22.8 2.3 9.8e-05 22.2 0.2 2.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.12 EWC47917.1 - 0.00011 21.7 7.1 0.059 13.3 0.2 4.6 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 EWC47917.1 - 0.00013 22.5 0.1 0.005 17.4 0.1 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat AAA_22 PF13401.1 EWC47917.1 - 0.00094 19.3 0.4 0.69 10.0 0.0 3.6 2 0 0 2 2 2 1 AAA domain TPR_1 PF00515.23 EWC47917.1 - 0.0024 17.3 1.7 0.86 9.3 0.1 3.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.1 EWC47917.1 - 0.0049 17.3 0.3 1.8 9.4 0.1 4.3 3 1 1 4 4 4 1 Tetratricopeptide repeat Apc3 PF12895.2 EWC47917.1 - 0.0063 16.6 0.1 0.018 15.1 0.0 1.8 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 Rep_2 PF01719.12 EWC47917.1 - 0.016 14.7 1.0 0.12 11.9 0.2 2.6 2 0 0 2 2 2 0 Plasmid replication protein TPR_17 PF13431.1 EWC47917.1 - 0.035 14.3 0.0 0.16 12.2 0.0 2.3 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_7 PF13176.1 EWC47917.1 - 0.036 13.8 6.5 3.9 7.5 0.1 4.4 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_8 PF13181.1 EWC47917.1 - 0.12 12.2 3.7 5.3 7.0 0.3 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Adaptin_N PF01602.15 EWC47918.1 - 4.7e-121 404.6 0.0 5.5e-121 404.4 0.0 1.0 1 0 0 1 1 1 1 Adaptin N terminal region HEAT_2 PF13646.1 EWC47918.1 - 1.7e-12 47.4 2.0 4.8e-05 23.5 0.0 4.8 2 1 2 4 4 4 2 HEAT repeats HEAT_EZ PF13513.1 EWC47918.1 - 5.3e-06 26.7 2.8 9.3 6.8 0.0 5.4 4 1 1 5 5 5 2 HEAT-like repeat HEAT PF02985.17 EWC47918.1 - 2.4e-05 24.0 0.9 1 9.6 0.0 5.2 6 0 0 6 6 6 2 HEAT repeat Cnd1 PF12717.2 EWC47918.1 - 0.042 13.7 2.3 0.53 10.1 0.1 3.3 3 1 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 MOR2-PAG1_N PF14222.1 EWC47918.1 - 0.061 11.9 0.1 0.11 11.1 0.0 1.3 1 0 0 1 1 1 0 Cell morphogenesis N-terminal Daxx PF03344.10 EWC47918.1 - 4.4 5.6 34.9 6.8 5.0 24.2 1.2 1 0 0 1 1 1 0 Daxx Family Nop14 PF04147.7 EWC47918.1 - 5 4.9 38.4 0.56 8.0 23.6 1.6 2 0 0 2 2 2 0 Nop14-like family TPR_12 PF13424.1 EWC47919.1 - 2.6e-08 33.7 6.8 3.1e-05 23.8 0.9 3.4 2 1 1 3 3 3 2 Tetratricopeptide repeat Clr5 PF14420.1 EWC47919.1 - 1.7e-06 27.8 0.1 3.8e-06 26.6 0.1 1.6 1 0 0 1 1 1 1 Clr5 domain TPR_19 PF14559.1 EWC47919.1 - 3.1e-05 24.2 3.7 0.0088 16.3 0.4 3.5 2 2 1 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.1 EWC47919.1 - 0.00032 20.5 10.5 0.049 13.5 0.2 4.5 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.1 EWC47919.1 - 0.0044 17.6 9.7 0.053 14.2 2.5 3.9 1 1 3 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.1 EWC47919.1 - 0.092 13.4 7.4 3.6 8.4 0.1 4.1 2 2 1 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.1 EWC47919.1 - 0.12 12.0 6.9 0.091 12.4 1.5 3.0 2 1 1 3 3 3 0 TPR repeat TPR_2 PF07719.12 EWC47919.1 - 1.8 8.6 7.9 2.3 8.3 1.1 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat Metallophos PF00149.23 EWC47921.1 - 2.2e-41 141.4 1.5 2.8e-41 141.1 1.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Nuc_recep-AF1 PF11825.3 EWC47922.1 - 1.4 8.8 6.9 0.49 10.3 0.1 2.3 2 0 0 2 2 2 0 Nuclear/hormone receptor activator site AF-1 HlyIII PF03006.15 EWC47923.1 - 9.7e-42 142.8 13.5 1.2e-41 142.5 9.4 1.0 1 0 0 1 1 1 1 Haemolysin-III related DUF962 PF06127.6 EWC47923.1 - 0.0072 16.2 1.7 0.21 11.4 1.2 2.5 2 1 0 2 2 2 1 Protein of unknown function (DUF962) DUF4231 PF14015.1 EWC47923.1 - 0.091 12.7 1.8 0.31 11.0 0.1 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF4231) DUF4149 PF13664.1 EWC47923.1 - 9.4 6.3 7.8 35 4.5 0.0 3.4 2 2 0 3 3 3 0 Domain of unknown function (DUF4149) Vps51 PF08700.6 EWC47924.1 - 7e-16 57.8 3.1 2.1e-15 56.3 2.1 1.9 1 0 0 1 1 1 1 Vps51/Vps67 COG2 PF06148.6 EWC47924.1 - 0.01 15.7 0.4 0.01 15.7 0.3 2.3 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF3619 PF12279.3 EWC47925.1 - 0.065 13.3 0.1 0.13 12.3 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3619) PAXNEB PF05625.6 EWC47927.1 - 6.2e-94 314.8 0.0 8.8e-94 314.3 0.0 1.2 1 1 0 1 1 1 1 PAXNEB protein Metallophos PF00149.23 EWC47930.1 - 4.4e-43 147.0 0.6 5.7e-43 146.6 0.4 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase ATP_bind_1 PF03029.12 EWC47931.1 - 1.5e-77 260.3 0.0 1.8e-77 260.0 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein CbiA PF01656.18 EWC47931.1 - 0.00019 20.9 0.0 0.00038 19.9 0.0 1.5 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_17 PF13207.1 EWC47931.1 - 0.00046 21.0 2.6 0.0042 17.9 0.1 2.7 2 1 0 2 2 2 1 AAA domain AAA_10 PF12846.2 EWC47931.1 - 0.0013 18.2 0.0 0.0022 17.5 0.0 1.5 1 1 0 1 1 1 1 AAA-like domain ArgK PF03308.11 EWC47931.1 - 0.0037 16.0 0.0 0.0085 14.8 0.0 1.5 1 0 0 1 1 1 1 ArgK protein MMR_HSR1 PF01926.18 EWC47931.1 - 0.0069 16.3 0.0 0.057 13.3 0.0 2.3 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_33 PF13671.1 EWC47931.1 - 0.011 15.5 0.0 0.032 14.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 EWC47931.1 - 0.022 14.7 0.1 0.11 12.4 0.1 2.2 1 1 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.1 EWC47931.1 - 0.036 13.6 0.0 0.078 12.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Zeta_toxin PF06414.7 EWC47931.1 - 0.048 12.7 0.0 0.39 9.7 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin AAA_19 PF13245.1 EWC47931.1 - 0.087 12.5 0.0 0.2 11.4 0.0 1.6 1 0 0 1 1 1 0 Part of AAA domain KTI12 PF08433.5 EWC47931.1 - 0.089 11.9 0.0 0.14 11.3 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 Fer4_NifH PF00142.13 EWC47931.1 - 0.1 11.7 0.1 0.4 9.8 0.0 1.9 1 1 1 2 2 2 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family MobB PF03205.9 EWC47931.1 - 0.14 11.8 0.0 0.49 10.0 0.0 1.9 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B SRP54 PF00448.17 EWC47931.1 - 0.15 11.5 0.0 0.35 10.2 0.0 1.6 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_18 PF13238.1 EWC47931.1 - 1.6 9.0 0.0 1.6 9.0 0.0 2.8 3 0 0 3 3 2 0 AAA domain NDUF_B4 PF07225.7 EWC47932.1 - 0.11 12.2 0.0 0.22 11.3 0.0 1.5 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4) RNase_P_Rpp14 PF01900.14 EWC47933.1 - 1.4e-33 115.0 0.0 1.9e-33 114.5 0.0 1.2 1 0 0 1 1 1 1 Rpp14/Pop5 family Vint PF14623.1 EWC47936.1 - 2e-41 141.1 0.0 3e-41 140.6 0.0 1.2 1 0 0 1 1 1 1 Hint-domain Vwaint PF14624.1 EWC47936.1 - 3.5e-26 91.1 0.0 6.9e-26 90.1 0.0 1.5 1 0 0 1 1 1 1 VWA / Hh protein intein-like VWA_2 PF13519.1 EWC47936.1 - 2e-21 76.8 0.1 8.7e-21 74.7 0.0 1.9 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_3 PF13768.1 EWC47936.1 - 2.8e-14 53.0 0.0 2.2e-13 50.1 0.0 2.2 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA PF00092.23 EWC47936.1 - 5.9e-13 48.9 0.0 1e-12 48.1 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain Hint PF01079.15 EWC47936.1 - 0.001 18.3 0.1 0.0016 17.7 0.0 1.2 1 0 0 1 1 1 1 Hint module adh_short PF00106.20 EWC47939.1 - 4.3e-14 52.7 0.1 7.7e-14 51.9 0.1 1.4 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EWC47939.1 - 3.6e-06 26.7 0.1 5.2e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 EWC47939.1 - 0.00024 20.9 0.0 0.00037 20.3 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.16 EWC47939.1 - 0.00044 19.7 0.1 0.00077 18.9 0.1 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 EWC47939.1 - 0.023 14.6 0.1 0.044 13.8 0.1 1.4 1 0 0 1 1 1 0 NADH(P)-binding DSPc PF00782.15 EWC47940.1 - 3e-32 110.9 0.0 1.4e-22 79.7 0.0 2.3 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 EWC47940.1 - 6e-06 25.7 0.0 0.00073 18.9 0.0 2.3 2 0 0 2 2 2 2 Protein-tyrosine phosphatase DUF3112 PF11309.3 EWC47941.1 - 4.4e-30 104.6 15.2 9.7e-29 100.2 4.9 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF3112) GDPD PF03009.12 EWC47942.1 - 1.8e-73 247.2 0.0 3.2e-73 246.3 0.0 1.5 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Ank_2 PF12796.2 EWC47942.1 - 1.9e-30 105.0 0.1 4.8e-19 68.4 0.1 3.7 3 0 0 3 3 3 2 Ankyrin repeats (3 copies) Ank PF00023.25 EWC47942.1 - 8.8e-25 85.2 8.1 5.3e-06 25.9 0.0 6.1 7 0 0 7 7 7 5 Ankyrin repeat Ank_4 PF13637.1 EWC47942.1 - 9.9e-25 86.4 2.6 6.7e-07 29.6 0.1 5.4 5 0 0 5 5 5 4 Ankyrin repeats (many copies) SPX PF03105.14 EWC47942.1 - 2.1e-23 83.4 10.6 1.3e-13 51.3 2.9 3.4 1 1 1 2 2 2 2 SPX domain Ank_5 PF13857.1 EWC47942.1 - 1.4e-19 69.6 2.0 2.5e-05 24.3 0.0 5.8 5 1 1 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.1 EWC47942.1 - 4.7e-19 66.5 1.0 0.00014 21.7 0.0 5.9 5 0 0 5 5 5 4 Ankyrin repeat OB_NTP_bind PF07717.11 EWC47943.1 - 7.8e-28 96.5 0.0 5.3e-26 90.6 0.0 2.9 3 0 0 3 3 3 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.18 EWC47943.1 - 4.4e-24 84.4 0.0 1e-23 83.2 0.0 1.7 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.26 EWC47943.1 - 4.2e-11 42.5 0.0 9.3e-11 41.4 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 EWC47943.1 - 8.1e-08 31.9 0.3 1.9e-07 30.7 0.2 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 EWC47943.1 - 7.2e-06 26.1 0.4 2.4e-05 24.4 0.1 2.0 2 0 0 2 2 2 1 AAA domain Flavi_DEAD PF07652.9 EWC47943.1 - 0.00027 20.6 0.1 0.00062 19.5 0.1 1.6 1 0 0 1 1 1 1 Flavivirus DEAD domain T2SE PF00437.15 EWC47943.1 - 0.0023 16.9 0.1 0.011 14.5 0.0 2.0 2 0 0 2 2 2 1 Type II/IV secretion system protein ResIII PF04851.10 EWC47943.1 - 0.0029 17.4 0.0 2.7 7.7 0.0 2.5 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit SRP54 PF00448.17 EWC47943.1 - 0.0092 15.4 0.2 0.044 13.2 0.2 2.1 2 1 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_30 PF13604.1 EWC47943.1 - 0.0098 15.4 0.0 0.021 14.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain PhoH PF02562.11 EWC47943.1 - 0.07 12.3 0.1 0.2 10.8 0.0 1.8 2 0 0 2 2 2 0 PhoH-like protein Peptidase_M20 PF01546.23 EWC47943.1 - 0.073 12.5 0.0 0.76 9.2 0.0 2.1 2 1 0 2 2 2 0 Peptidase family M20/M25/M40 DUF2435 PF10363.4 EWC47944.1 - 1e-23 83.0 1.7 2.5e-23 81.7 0.1 2.7 3 0 0 3 3 3 1 Protein of unknown function (DUF2435) DUF2411 PF10304.4 EWC47944.1 - 7.9e-05 22.0 1.8 0.00012 21.4 0.4 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF2411) HEAT_EZ PF13513.1 EWC47944.1 - 0.67 10.5 14.1 6.1 7.4 0.1 5.8 6 0 0 6 6 6 0 HEAT-like repeat Rieske PF00355.21 EWC47945.1 - 3.1e-18 65.1 0.0 5.1e-18 64.4 0.0 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain UCR_TM PF02921.9 EWC47945.1 - 2.3e-17 62.9 0.6 4.5e-17 62.0 0.4 1.4 1 0 0 1 1 1 1 Ubiquinol cytochrome reductase transmembrane region LSM PF01423.17 EWC47946.1 - 1.7e-19 69.0 0.2 2e-19 68.9 0.1 1.1 1 0 0 1 1 1 1 LSM domain IBR PF01485.16 EWC47947.1 - 7.8e-07 28.8 25.0 0.00064 19.5 4.1 3.5 3 0 0 3 3 3 3 IBR domain PI31_Prot_N PF11566.3 EWC47949.1 - 8.1e-29 100.2 0.0 1e-28 99.8 0.0 1.1 1 0 0 1 1 1 1 PI31 proteasome regulator N-terminal PI31_Prot_C PF08577.6 EWC47949.1 - 1.9e-12 47.6 17.7 1.9e-12 47.6 12.2 3.2 3 1 0 3 3 3 1 PI31 proteasome regulator Cobalamin_bind PF01122.14 EWC47949.1 - 0.049 12.2 0.0 0.069 11.7 0.0 1.1 1 0 0 1 1 1 0 Eukaryotic cobalamin-binding protein zf-C2H2 PF00096.21 EWC47950.1 - 1.4e-08 34.5 16.0 0.004 17.3 0.4 3.8 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EWC47950.1 - 2e-05 24.5 23.3 0.0015 18.7 0.4 4.1 4 0 0 4 4 4 3 C2H2-type zinc finger zf-met PF12874.2 EWC47950.1 - 0.012 15.8 2.3 0.3 11.3 0.1 2.7 2 0 0 2 2 2 0 Zinc-finger of C2H2 type Creatininase PF02633.9 EWC47950.1 - 0.052 12.6 0.0 0.088 11.8 0.0 1.3 1 0 0 1 1 1 0 Creatinine amidohydrolase zf-H2C2_2 PF13465.1 EWC47950.1 - 0.61 10.4 24.2 0.11 12.8 1.3 3.7 4 0 0 4 4 4 0 Zinc-finger double domain zf-C2H2_jaz PF12171.3 EWC47950.1 - 0.67 10.1 6.9 2.4 8.4 0.3 3.5 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding PAT1 PF09770.4 EWC47951.1 - 1.1e-216 721.8 22.2 1.3e-216 721.6 15.4 1.0 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 Glyco_transf_15 PF01793.11 EWC47952.1 - 1.6e-142 474.3 4.9 1.9e-142 474.1 3.4 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase EGF_3 PF12947.2 EWC47952.1 - 0.024 14.6 1.7 0.044 13.7 1.2 1.5 1 0 0 1 1 1 0 EGF domain Ribosom_S12_S23 PF00164.20 EWC47953.1 - 6e-41 138.7 0.9 7.5e-41 138.3 0.6 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 She9_MDM33 PF05546.6 EWC47954.1 - 1.6e-73 246.6 8.4 2.5e-73 246.0 5.8 1.2 1 0 0 1 1 1 1 She9 / Mdm33 family Herpes_UL92 PF03048.9 EWC47954.1 - 0.022 14.3 0.0 0.046 13.2 0.0 1.4 1 0 0 1 1 1 0 UL92 family PsbH PF00737.15 EWC47954.1 - 0.037 13.6 0.2 0.074 12.6 0.2 1.5 1 0 0 1 1 1 0 Photosystem II 10 kDa phosphoprotein FANCI_HD2 PF14680.1 EWC47954.1 - 0.052 12.6 0.0 0.12 11.4 0.0 1.5 1 0 0 1 1 1 0 FANCI helical domain 2 WHEP-TRS PF00458.15 EWC47954.1 - 0.062 12.9 0.3 0.2 11.3 0.2 1.9 1 0 0 1 1 1 0 WHEP-TRS domain Arrestin_C PF02752.17 EWC47955.1 - 3e-15 56.5 0.4 1.1e-14 54.7 0.0 2.0 2 1 1 3 3 3 1 Arrestin (or S-antigen), C-terminal domain Peptidase_C48 PF02902.14 EWC47956.1 - 5.7e-27 94.7 0.0 9.3e-27 94.0 0.0 1.3 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Skp1_POZ PF03931.10 EWC47957.1 - 4.6e-10 39.4 0.0 6.2e-09 35.8 0.0 2.1 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain tRNA_int_end_N2 PF12928.2 EWC47958.1 - 5.2e-25 86.7 0.0 8.5e-25 86.0 0.0 1.4 1 0 0 1 1 1 1 tRNA-splicing endonuclease subunit sen54 N-term HAD PF12710.2 EWC47959.1 - 1.3e-15 58.0 0.0 1.8e-15 57.5 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.7 EWC47959.1 - 5.3e-05 22.5 0.0 0.00017 20.8 0.0 1.7 1 1 0 1 1 1 1 Putative Phosphatase HAD_2 PF13419.1 EWC47959.1 - 0.0028 17.8 0.0 0.013 15.7 0.0 2.0 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase UMPH-1 PF05822.7 EWC47959.1 - 0.0049 16.2 0.0 0.0086 15.4 0.0 1.5 1 0 0 1 1 1 1 Pyrimidine 5'-nucleotidase (UMPH-1) Hydrolase PF00702.21 EWC47959.1 - 0.033 14.6 0.0 1.8 8.9 0.0 2.6 2 1 1 3 3 3 0 haloacid dehalogenase-like hydrolase Voltage_CLC PF00654.15 EWC47960.1 - 3.9e-89 299.1 25.2 3.9e-89 299.1 17.5 1.5 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.23 EWC47960.1 - 2.7e-13 49.4 0.1 5.2e-06 26.1 0.0 2.5 2 0 0 2 2 2 2 CBS domain CBFD_NFYB_HMF PF00808.18 EWC47961.1 - 7e-11 42.0 1.0 8.1e-11 41.8 0.1 1.6 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone PPR_2 PF13041.1 EWC47962.1 - 6.2e-05 22.8 0.7 0.0001 22.1 0.0 1.7 2 0 0 2 2 2 1 PPR repeat family SNARE PF05739.14 EWC47963.1 - 9.1e-17 60.5 1.9 2.9e-16 58.8 1.3 1.9 1 0 0 1 1 1 1 SNARE domain SlyX PF04102.7 EWC47963.1 - 0.011 16.1 7.4 8.8 6.7 0.0 3.7 2 1 1 3 3 3 0 SlyX IncA PF04156.9 EWC47963.1 - 0.018 14.6 1.4 0.018 14.6 1.0 3.1 3 0 0 3 3 3 0 IncA protein ATG16 PF08614.6 EWC47964.1 - 0.0083 15.9 2.0 0.01 15.7 1.4 1.0 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) PBP_sp32 PF07222.7 EWC47964.1 - 0.097 11.8 1.1 0.11 11.6 0.7 1.0 1 0 0 1 1 1 0 Proacrosin binding protein sp32 DUF4452 PF14618.1 EWC47965.1 - 4.8e-41 140.3 6.7 5.7e-41 140.0 4.6 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4452) Cyclin_N PF00134.18 EWC47966.1 - 6e-14 51.7 2.7 1.2e-12 47.4 0.4 2.3 2 0 0 2 2 2 2 Cyclin, N-terminal domain TFIIB PF00382.14 EWC47966.1 - 0.024 14.4 0.1 0.057 13.2 0.0 1.7 1 0 0 1 1 1 0 Transcription factor TFIIB repeat Mito_carr PF00153.22 EWC47967.1 - 6.5e-61 202.0 2.8 3e-23 81.3 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.1 EWC47967.1 - 5.9e-25 87.1 4.9 9.5e-12 44.8 0.2 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 EWC47967.1 - 6.6e-23 78.2 6.0 3.2e-06 26.0 0.5 4.4 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 EWC47967.1 - 1.5e-20 71.1 9.0 4.5e-05 22.9 0.7 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.1 EWC47967.1 - 5.6e-17 60.2 9.7 1.9e-06 26.9 0.6 4.4 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.1 EWC47967.1 - 1.6e-15 56.4 3.6 4.8e-07 29.2 0.0 3.5 2 2 2 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.4 EWC47967.1 - 9.8e-11 41.6 0.1 0.00034 20.6 0.0 2.3 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.1 EWC47967.1 - 4.7e-05 22.9 1.0 0.1 12.2 0.1 3.7 2 1 2 4 4 4 2 EF hand EF-hand_9 PF14658.1 EWC47967.1 - 0.00014 21.7 0.0 0.16 11.8 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.2 EWC47967.1 - 0.003 17.2 2.0 0.38 10.5 0.2 2.9 1 1 2 3 3 3 1 Cytoskeletal-regulatory complex EF hand HORMA PF02301.13 EWC47968.1 - 5.2e-22 78.3 0.0 6.7e-22 77.9 0.0 1.1 1 0 0 1 1 1 1 HORMA domain IBN_N PF03810.14 EWC47969.1 - 4.2e-13 49.0 0.0 3.2e-11 42.9 0.0 3.5 3 0 0 3 3 3 1 Importin-beta N-terminal domain HEAT PF02985.17 EWC47969.1 - 1.1e-06 28.1 0.1 0.0079 16.1 0.0 4.4 2 0 0 2 2 2 2 HEAT repeat HEAT_2 PF13646.1 EWC47969.1 - 1.4e-05 25.2 4.6 0.029 14.6 0.1 5.0 3 2 0 3 3 3 2 HEAT repeats Xpo1 PF08389.7 EWC47969.1 - 3.8e-05 23.6 0.1 0.00035 20.5 0.0 2.9 2 1 0 2 2 2 1 Exportin 1-like protein Cnd1 PF12717.2 EWC47969.1 - 0.002 17.9 0.1 0.15 11.9 0.0 2.9 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 Cse1 PF08506.5 EWC47969.1 - 0.052 12.1 0.2 6.1 5.2 0.0 2.5 1 1 1 2 2 2 0 Cse1 HEAT_EZ PF13513.1 EWC47969.1 - 0.11 13.0 7.1 33 5.1 0.0 5.9 5 0 0 5 5 5 0 HEAT-like repeat Pkinase PF00069.20 EWC47970.1 - 5.2e-22 78.2 0.0 1.1e-21 77.1 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain HEAT PF02985.17 EWC47970.1 - 5.2e-13 47.8 3.2 0.0022 17.9 0.0 6.0 5 0 0 5 5 5 4 HEAT repeat WD40 PF00400.27 EWC47970.1 - 5.7e-12 45.0 1.0 2.5e-08 33.4 0.0 4.5 5 0 0 5 5 5 1 WD domain, G-beta repeat HEAT_2 PF13646.1 EWC47970.1 - 4.1e-09 36.6 0.2 0.025 14.8 0.3 3.5 2 1 2 4 4 4 4 HEAT repeats Pkinase_Tyr PF07714.12 EWC47970.1 - 2.9e-06 26.5 0.0 4.5e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Adaptin_N PF01602.15 EWC47970.1 - 0.00053 18.4 1.5 0.12 10.6 0.0 2.5 3 0 0 3 3 3 2 Adaptin N terminal region HEAT_EZ PF13513.1 EWC47970.1 - 0.0052 17.2 5.1 0.024 15.1 0.7 3.5 4 0 0 4 4 4 1 HEAT-like repeat DUF2435 PF10363.4 EWC47970.1 - 0.008 16.0 0.0 1.5 8.7 0.0 2.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2435) Cnd1 PF12717.2 EWC47970.1 - 0.0092 15.8 0.5 4.9 6.9 0.0 2.9 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 LRR_9 PF14580.1 EWC47971.1 - 6.2e-34 117.0 0.2 9.9e-34 116.4 0.1 1.3 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.2 EWC47971.1 - 2.9e-07 29.9 5.3 0.00077 19.0 0.2 2.7 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 EWC47971.1 - 9.3e-06 25.3 2.2 0.00016 21.3 0.6 2.3 1 1 1 2 2 2 2 Leucine rich repeat LRR_1 PF00560.28 EWC47971.1 - 1.1 9.5 3.3 32 5.0 0.0 3.6 3 1 1 4 4 4 0 Leucine Rich Repeat GMP_synt_C PF00958.17 EWC47972.1 - 6.5e-39 131.5 0.2 2.5e-38 129.6 0.0 2.1 2 1 0 2 2 2 1 GMP synthase C terminal domain GATase PF00117.23 EWC47972.1 - 1.4e-29 102.9 0.0 3.7e-29 101.5 0.0 1.7 2 0 0 2 2 2 1 Glutamine amidotransferase class-I NAD_synthase PF02540.12 EWC47972.1 - 8.8e-11 41.1 0.1 1.3e-06 27.4 0.0 2.1 2 0 0 2 2 2 2 NAD synthase Peptidase_C26 PF07722.8 EWC47972.1 - 4.1e-05 23.1 0.0 9.9e-05 21.8 0.0 1.6 1 0 0 1 1 1 1 Peptidase C26 tRNA_Me_trans PF03054.11 EWC47972.1 - 0.00032 19.3 0.2 0.00067 18.3 0.1 1.5 2 0 0 2 2 2 1 tRNA methyl transferase QueC PF06508.8 EWC47972.1 - 0.0018 17.5 0.0 0.029 13.6 0.0 2.1 1 1 0 1 1 1 1 Queuosine biosynthesis protein QueC Asn_synthase PF00733.16 EWC47972.1 - 0.0019 17.7 0.1 0.0033 16.9 0.0 1.3 1 0 0 1 1 1 1 Asparagine synthase PAPS_reduct PF01507.14 EWC47972.1 - 0.0041 16.9 0.0 0.0063 16.3 0.0 1.3 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family Arginosuc_synth PF00764.14 EWC47972.1 - 0.01 14.9 0.1 0.017 14.1 0.0 1.3 1 0 0 1 1 1 0 Arginosuccinate synthase ThiI PF02568.9 EWC47972.1 - 0.031 13.7 0.0 0.062 12.7 0.0 1.5 2 0 0 2 2 2 0 Thiamine biosynthesis protein (ThiI) ATP_bind_3 PF01171.15 EWC47972.1 - 0.054 12.9 0.0 0.1 12.1 0.0 1.4 1 0 0 1 1 1 0 PP-loop family PAP2 PF01569.16 EWC47973.1 - 1.3e-18 66.9 3.6 3.3e-18 65.5 2.5 1.7 1 0 0 1 1 1 1 PAP2 superfamily Thr_synth_N PF14821.1 EWC47974.1 - 1.2e-28 98.9 0.0 1.8e-26 91.9 0.0 2.5 2 0 0 2 2 2 2 Threonine synthase N terminus PALP PF00291.20 EWC47974.1 - 5.5e-19 68.5 0.0 1e-17 64.3 0.0 2.1 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme SH3_9 PF14604.1 EWC47975.1 - 6e-08 32.1 0.1 1.3e-07 31.0 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 EWC47975.1 - 0.00044 19.5 0.1 0.00091 18.5 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SKG6 PF08693.5 EWC47975.1 - 0.22 10.8 0.5 0.44 9.8 0.3 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain DUF2204 PF09970.4 EWC47976.1 - 0.0012 18.4 0.0 0.0013 18.2 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase of unknown function (DUF2204) DUF1814 PF08843.6 EWC47976.1 - 0.0086 15.8 0.0 0.0097 15.7 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase of unknown function (DUF1814) BCIP PF13862.1 EWC47978.1 - 8.6e-59 198.3 0.0 1.1e-58 197.9 0.0 1.1 1 0 0 1 1 1 1 p21-C-terminal region-binding protein polyprenyl_synt PF00348.12 EWC47979.1 - 2.2e-50 170.9 0.0 1.4e-47 161.7 0.0 2.1 2 0 0 2 2 2 2 Polyprenyl synthetase HEPPP_synt_1 PF07307.6 EWC47979.1 - 0.022 14.2 0.0 0.036 13.5 0.0 1.2 1 0 0 1 1 1 0 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1 EI24 PF07264.6 EWC47980.1 - 4.4e-05 23.0 4.1 4.4e-05 23.0 2.8 2.5 2 2 0 2 2 2 1 Etoposide-induced protein 2.4 (EI24) SYS1 PF09801.4 EWC47981.1 - 1.7e-48 164.2 13.0 2e-48 164.0 9.0 1.0 1 0 0 1 1 1 1 Integral membrane protein S linking to the trans Golgi network Gly-zipper_OmpA PF13436.1 EWC47981.1 - 6.3 6.4 7.8 11 5.7 5.4 1.3 1 0 0 1 1 1 0 Glycine-zipper containing OmpA-like membrane domain Gti1_Pac2 PF09729.4 EWC47982.1 - 1.3e-51 174.8 0.7 9.6e-51 171.9 0.5 1.9 1 1 0 1 1 1 1 Gti1/Pac2 family tRNA_anti-codon PF01336.20 EWC47983.1 - 2.2e-08 33.7 0.0 2.9e-08 33.4 0.0 1.2 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain DUF2263 PF10021.4 EWC47984.1 - 4.1e-15 56.0 0.0 6.1e-15 55.4 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2263) PIP5K PF01504.13 EWC47985.1 - 3.7e-81 271.9 0.0 5.2e-81 271.4 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase WD40 PF00400.27 EWC47986.1 - 1.6e-36 122.8 8.8 5.1e-10 38.8 0.1 6.7 7 0 0 7 7 7 6 WD domain, G-beta repeat Nup160 PF11715.3 EWC47986.1 - 2.9e-08 32.3 17.0 0.001 17.2 0.6 4.8 3 2 1 4 4 4 3 Nucleoporin Nup120/160 PQQ_2 PF13360.1 EWC47986.1 - 0.0059 16.1 2.6 0.28 10.5 0.1 3.1 3 0 0 3 3 3 1 PQQ-like domain APG6 PF04111.7 EWC47986.1 - 0.0062 15.6 0.4 0.0092 15.0 0.3 1.1 1 0 0 1 1 1 1 Autophagy protein Apg6 Nup54 PF13874.1 EWC47986.1 - 0.089 12.4 0.0 0.2 11.2 0.0 1.5 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 HSF_DNA-bind PF00447.12 EWC47988.1 - 3.7e-37 126.6 1.0 6.2e-37 125.9 0.7 1.3 1 0 0 1 1 1 1 HSF-type DNA-binding Response_reg PF00072.19 EWC47988.1 - 1.8e-18 66.5 0.0 3.5e-18 65.6 0.0 1.5 1 0 0 1 1 1 1 Response regulator receiver domain Tektin PF03148.9 EWC47988.1 - 0.025 13.1 0.3 0.034 12.6 0.2 1.1 1 0 0 1 1 1 0 Tektin family Adaptin_N PF01602.15 EWC47989.1 - 3.2e-143 477.8 10.4 3.7e-143 477.6 7.2 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.2 EWC47989.1 - 2.9e-26 92.4 3.4 2.4e-25 89.3 0.1 2.8 3 1 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.1 EWC47989.1 - 3e-17 62.6 6.9 1.3e-06 28.5 0.0 5.8 2 1 5 7 7 7 5 HEAT repeats HEAT PF02985.17 EWC47989.1 - 9.7e-12 43.9 2.9 0.0094 15.9 0.0 6.3 7 0 0 7 7 7 3 HEAT repeat HEAT_EZ PF13513.1 EWC47989.1 - 1.8e-07 31.4 0.0 0.65 10.5 0.0 6.4 5 1 1 6 6 6 1 HEAT-like repeat Arm PF00514.18 EWC47989.1 - 0.00074 19.2 1.0 18 5.3 0.0 5.3 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat CLASP_N PF12348.3 EWC47989.1 - 0.0013 18.1 1.9 0.65 9.3 0.0 3.8 3 2 2 5 5 5 2 CLASP N terminal Cnd3 PF12719.2 EWC47989.1 - 0.0057 15.6 0.8 0.034 13.1 0.1 2.4 3 0 0 3 3 3 1 Nuclear condensing complex subunits, C-term domain Cohesin_HEAT PF12765.2 EWC47989.1 - 0.023 14.6 0.2 31 4.6 0.0 4.4 4 0 0 4 4 4 0 HEAT repeat associated with sister chromatid cohesion AF0941-like PF14591.1 EWC47989.1 - 0.25 11.4 5.5 0.14 12.2 0.9 2.7 4 0 0 4 4 4 0 AF0941-like BCS1_N PF08740.6 EWC47990.1 - 2.8e-28 98.8 0.1 2.8e-28 98.8 0.1 1.9 2 0 0 2 2 2 1 BCS1 N terminal AAA PF00004.24 EWC47990.1 - 9.2e-16 58.2 0.0 4.5e-14 52.7 0.0 2.5 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.1 EWC47990.1 - 0.0037 16.6 0.0 0.008 15.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_21 PF13304.1 EWC47990.1 - 0.0063 16.5 0.1 0.0063 16.5 0.0 2.6 2 1 1 3 3 3 1 AAA domain AAA_17 PF13207.1 EWC47990.1 - 0.022 15.5 4.5 0.2 12.4 3.1 2.7 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.9 EWC47990.1 - 0.023 14.4 0.0 0.14 11.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 EWC47990.1 - 0.066 13.1 0.1 0.27 11.2 0.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain DUF1675 PF07897.6 EWC47990.1 - 2.2 8.0 10.8 4.2 7.1 7.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) SNF2_N PF00176.18 EWC47991.1 - 6.6e-66 222.1 0.0 2.9e-65 220.0 0.0 1.8 2 0 0 2 2 2 1 SNF2 family N-terminal domain Rad54_N PF08658.5 EWC47991.1 - 8.7e-46 156.1 3.6 8.8e-46 156.1 1.5 1.6 2 0 0 2 2 2 1 Rad54 N terminal Helicase_C PF00271.26 EWC47991.1 - 1.3e-12 47.3 0.0 3.7e-12 45.9 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HDA2-3 PF11496.3 EWC47991.1 - 1.3e-05 24.2 0.0 4.5e-05 22.3 0.0 1.9 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 DEAD PF00270.24 EWC47991.1 - 2.6e-05 23.8 0.0 0.0013 18.2 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase WD40 PF00400.27 EWC47994.1 - 4.1e-13 48.6 5.6 0.0006 19.6 0.0 5.1 5 0 0 5 5 5 3 WD domain, G-beta repeat SURF6 PF04935.7 EWC47995.1 - 1.6e-45 155.0 41.1 1.6e-45 155.0 28.5 4.7 2 1 1 4 4 4 1 Surfeit locus protein 6 RRP14 PF15459.1 EWC47995.1 - 5e-20 71.3 3.5 5e-20 71.3 2.4 7.3 5 2 0 5 5 5 1 60S ribosome biogenesis protein Rrp14 COQ9 PF08511.6 EWC47996.1 - 2.1e-21 75.1 0.2 2.5e-21 74.9 0.1 1.1 1 0 0 1 1 1 1 COQ9 RRM_1 PF00076.17 EWC47997.1 - 1.3e-52 175.2 0.0 4e-18 64.8 0.0 3.9 3 1 1 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EWC47997.1 - 2.2e-41 139.6 0.0 1.4e-14 53.8 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EWC47997.1 - 8.3e-24 83.2 0.0 9.3e-07 28.6 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 EWC47997.1 - 1.2e-07 31.4 0.0 0.14 12.0 0.0 3.6 3 1 1 4 4 4 3 RNA binding motif DUF1777 PF08648.7 EWC47997.1 - 1.1e-05 25.2 16.7 1.6e-05 24.7 11.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1777) Limkain-b1 PF11608.3 EWC47997.1 - 0.00037 20.2 0.0 0.57 9.9 0.0 3.4 3 1 0 3 3 3 1 Limkain b1 ATP-grasp_2 PF08442.5 EWC47997.1 - 0.0017 17.8 0.0 0.048 13.0 0.0 2.7 3 0 0 3 3 3 1 ATP-grasp domain GRP PF07172.6 EWC47997.1 - 5.7 7.4 47.7 12 6.5 0.3 3.6 3 0 0 3 3 3 0 Glycine rich protein family BolA PF01722.13 EWC47998.1 - 2e-20 72.5 0.0 2.3e-20 72.3 0.0 1.1 1 0 0 1 1 1 1 BolA-like protein PP-binding PF00550.20 EWC47999.1 - 1e-10 41.7 0.2 1.5e-10 41.1 0.1 1.3 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.1 EWC47999.1 - 9.5e-06 25.5 0.1 1.3e-05 25.1 0.1 1.1 1 0 0 1 1 1 1 Acyl-carrier DUF1493 PF07377.7 EWC47999.1 - 0.017 15.2 0.1 0.024 14.7 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1493) GPP34 PF05719.6 EWC48000.1 - 4e-42 144.6 0.3 5e-42 144.3 0.2 1.1 1 0 0 1 1 1 1 Golgi phosphoprotein 3 (GPP34) Ank_2 PF12796.2 EWC48001.1 - 4.6e-37 126.2 2.3 1.5e-14 54.0 0.1 2.7 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 EWC48001.1 - 5.3e-26 89.0 3.0 3.6e-09 35.9 0.0 5.1 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.1 EWC48001.1 - 1.7e-24 85.2 0.2 9.1e-10 38.4 0.0 3.5 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 EWC48001.1 - 3.9e-20 69.9 1.6 6.2e-05 22.8 0.0 4.6 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.1 EWC48001.1 - 4.7e-20 71.5 0.8 5.6e-10 39.4 0.1 4.3 3 1 1 4 4 4 3 Ankyrin repeats (many copies) PEGA PF08308.6 EWC48001.1 - 0.094 12.5 0.0 2.4 8.0 0.0 3.0 4 0 0 4 4 4 0 PEGA domain UCH PF00443.24 EWC48002.1 - 8.6e-46 156.2 0.0 3.8e-45 154.0 0.0 1.9 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RPT PF13446.1 EWC48002.1 - 1.3e-32 110.9 0.0 6.1e-16 57.5 0.0 4.3 4 0 0 4 4 4 3 A repeated domain in UCH-protein UCH_1 PF13423.1 EWC48002.1 - 1.9e-10 40.6 2.0 2.8e-06 26.9 0.2 2.8 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase IBB PF01749.15 EWC48002.1 - 0.97 9.6 5.1 0.21 11.7 0.9 1.9 2 0 0 2 2 2 0 Importin beta binding domain Tim17 PF02466.14 EWC48003.1 - 1.5e-10 41.2 3.8 2.2e-10 40.6 2.6 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family NACHT PF05729.7 EWC48004.1 - 8.4e-05 22.2 0.2 0.0017 18.0 0.0 2.9 2 1 0 2 2 2 1 NACHT domain AAA_16 PF13191.1 EWC48004.1 - 0.0069 16.3 0.3 0.091 12.7 0.0 2.8 3 0 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.1 EWC48004.1 - 0.0078 16.3 0.0 0.026 14.6 0.0 2.0 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.22 EWC48004.1 - 0.0081 16.4 0.1 0.025 14.8 0.0 1.8 1 0 0 1 1 1 1 ABC transporter DUF258 PF03193.11 EWC48004.1 - 0.011 14.9 0.0 0.025 13.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 MMR_HSR1 PF01926.18 EWC48004.1 - 0.016 15.1 0.0 0.11 12.4 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_29 PF13555.1 EWC48004.1 - 0.02 14.4 0.0 0.046 13.2 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.1 EWC48004.1 - 0.036 14.3 0.4 0.036 14.3 0.3 2.5 1 1 1 2 2 2 0 AAA domain AAA_18 PF13238.1 EWC48004.1 - 0.038 14.2 0.4 0.42 10.9 0.1 2.7 2 0 0 2 2 2 0 AAA domain AAA_10 PF12846.2 EWC48004.1 - 0.058 12.8 0.5 0.35 10.2 0.0 2.4 3 0 0 3 3 3 0 AAA-like domain AAA_30 PF13604.1 EWC48004.1 - 0.06 12.9 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.1 EWC48004.1 - 0.27 12.0 2.9 0.37 11.6 0.1 2.7 3 0 0 3 3 2 0 AAA domain Glyco_hydro_17 PF00332.13 EWC48005.1 - 0.0015 17.6 0.4 0.0032 16.5 0.3 1.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 17 Glyco_hydro_53 PF07745.8 EWC48005.1 - 0.0059 15.4 0.2 0.0089 14.8 0.2 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 53 MSA-2c PF12238.3 EWC48005.1 - 0.08 12.6 1.9 0.19 11.3 1.4 1.6 1 0 0 1 1 1 0 Merozoite surface antigen 2c DUF914 PF06027.7 EWC48006.1 - 1e-107 359.8 20.7 1.3e-107 359.5 14.3 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF914) EamA PF00892.15 EWC48006.1 - 0.00024 21.1 7.5 0.00024 21.1 5.2 2.6 2 1 0 2 2 2 1 EamA-like transporter family Ninjurin PF04923.7 EWC48006.1 - 0.17 11.6 1.5 0.18 11.5 0.1 1.7 2 0 0 2 2 2 0 Ninjurin OPT PF03169.10 EWC48007.1 - 3.6e-186 620.2 56.1 4.1e-186 620.1 38.9 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein EIAV_GP90 PF00971.13 EWC48007.1 - 0.0071 14.8 0.4 0.013 13.9 0.3 1.3 1 0 0 1 1 1 1 EIAV coat protein, gp90 CcmD PF04995.9 EWC48007.1 - 0.02 14.6 1.0 0.088 12.5 0.7 2.1 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) DUF4191 PF13829.1 EWC48007.1 - 0.034 13.2 1.1 0.11 11.5 0.7 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) BofA PF07441.6 EWC48007.1 - 2.5 8.1 17.1 0.024 14.6 4.3 3.3 3 0 0 3 3 3 0 SigmaK-factor processing regulatory protein BofA DUF3972 PF13118.1 EWC48008.1 - 0.3 11.1 13.4 0.48 10.5 5.7 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3972) AD PF09793.4 EWC48008.1 - 0.64 9.9 3.0 7.1 6.5 0.1 2.9 2 0 0 2 2 2 0 Anticodon-binding domain V_ATPase_I PF01496.14 EWC48008.1 - 0.97 7.2 29.3 0.32 8.7 3.6 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family GAGA_bind PF06217.7 EWC48008.1 - 8 6.3 18.3 4.6 7.1 0.2 2.2 2 0 0 2 2 2 0 GAGA binding protein-like family Sugar_tr PF00083.19 EWC48009.1 - 1.7e-13 50.0 9.3 1.8e-13 49.8 6.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter DUF606 PF04657.8 EWC48009.1 - 0.33 11.0 3.3 0.44 10.6 2.3 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF606 MFS_1 PF07690.11 EWC48009.1 - 4.6 5.8 11.5 0.099 11.3 3.7 1.3 2 0 0 2 2 2 0 Major Facilitator Superfamily Peptidase_M10 PF00413.19 EWC48010.1 - 5.7e-18 65.1 0.0 6.7e-18 64.8 0.0 1.1 1 0 0 1 1 1 1 Matrixin Metallopep PF12044.3 EWC48010.1 - 0.017 13.5 0.0 0.023 13.1 0.0 1.2 1 0 0 1 1 1 0 Putative peptidase family Peptidase_M54 PF07998.6 EWC48010.1 - 0.023 14.4 0.0 0.034 13.8 0.0 1.2 1 0 0 1 1 1 0 Peptidase family M54 Peptidase_M66 PF10462.4 EWC48010.1 - 0.028 13.3 0.4 0.041 12.7 0.3 1.2 1 0 0 1 1 1 0 Peptidase M66 Reprolysin_4 PF13583.1 EWC48010.1 - 0.036 13.6 0.1 0.047 13.2 0.1 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like DUF885 PF05960.6 EWC48010.1 - 0.051 12.7 0.0 0.055 12.6 0.0 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF885) Astacin PF01400.19 EWC48010.1 - 0.052 12.9 0.1 4.4 6.6 0.0 2.3 2 0 0 2 2 2 0 Astacin (Peptidase family M12A) DUF3152 PF11350.3 EWC48010.1 - 0.085 12.3 0.3 0.29 10.6 0.2 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3152) Reprolysin_3 PF13582.1 EWC48010.1 - 0.15 12.5 0.1 0.23 11.9 0.1 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Sugar_tr PF00083.19 EWC48011.1 - 1.5e-16 60.0 32.5 1.7e-16 59.9 18.0 2.4 2 1 0 2 2 2 1 Sugar (and other) transporter DUF1996 PF09362.5 EWC48013.1 - 2.4e-69 233.5 0.9 3.3e-69 233.1 0.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) Carb_anhydrase PF00194.16 EWC48014.1 - 6e-27 94.2 0.0 9e-27 93.6 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase ADH_N PF08240.7 EWC48016.1 - 3.3e-27 94.4 2.8 5.6e-27 93.6 2.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 EWC48016.1 - 1.4e-17 63.4 1.1 3.8e-17 62.0 0.0 2.0 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 EWC48016.1 - 8.1e-05 23.5 0.0 0.00015 22.6 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.14 EWC48016.1 - 0.00018 20.6 0.2 0.0003 20.0 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.13 EWC48016.1 - 0.0015 18.1 0.3 0.1 12.2 0.3 2.2 1 1 1 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain TrkA_N PF02254.13 EWC48016.1 - 0.0024 17.8 0.2 0.0041 17.1 0.1 1.4 1 0 0 1 1 1 1 TrkA-N domain NAD_binding_10 PF13460.1 EWC48016.1 - 0.0061 16.5 0.2 0.01 15.8 0.1 1.3 1 0 0 1 1 1 1 NADH(P)-binding NAD_binding_2 PF03446.10 EWC48016.1 - 0.008 16.0 0.2 0.016 15.0 0.1 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase ApbA PF02558.11 EWC48016.1 - 0.02 14.3 0.3 0.037 13.4 0.2 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA ThiF PF00899.16 EWC48016.1 - 0.046 13.5 2.1 0.11 12.2 1.4 1.7 1 0 0 1 1 1 0 ThiF family Shikimate_DH PF01488.15 EWC48016.1 - 0.1 12.6 0.2 0.24 11.5 0.1 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase GFA PF04828.9 EWC48017.1 - 1.9e-21 75.7 1.8 1.9e-21 75.7 1.3 1.5 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme UK PF02512.9 EWC48017.1 - 0.14 12.6 0.2 0.18 12.2 0.1 1.3 1 0 0 1 1 1 0 Virulence determinant RTC PF01137.16 EWC48019.1 - 3.6e-34 117.5 0.0 5.2e-34 117.0 0.0 1.1 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.8 EWC48019.1 - 1.1e-24 86.3 0.0 2.1e-24 85.5 0.0 1.5 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain VSP PF03302.8 EWC48020.1 - 0.00057 18.6 0.1 0.00089 17.9 0.1 1.3 1 0 0 1 1 1 1 Giardia variant-specific surface protein SKG6 PF08693.5 EWC48020.1 - 0.0014 17.8 3.3 0.0039 16.4 2.3 1.7 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Mid2 PF04478.7 EWC48020.1 - 0.045 13.1 0.0 0.1 12.0 0.0 1.6 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor Syndecan PF01034.15 EWC48020.1 - 0.22 11.1 0.4 0.4 10.3 0.3 1.3 1 0 0 1 1 1 0 Syndecan domain MtrF PF09472.5 EWC48020.1 - 0.85 8.9 3.6 1.4 8.2 2.5 1.3 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) Rubella_E2 PF05749.6 EWC48021.1 - 0.18 11.0 1.2 0.24 10.6 0.8 1.1 1 0 0 1 1 1 0 Rubella membrane glycoprotein E2 zf-C2HC5 PF06221.8 EWC48022.1 - 1.6e-19 69.4 5.9 2.7e-19 68.6 4.1 1.4 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type CsoSCA PF08936.5 EWC48022.1 - 0.19 10.0 0.0 0.28 9.4 0.0 1.1 1 0 0 1 1 1 0 Carboxysome Shell Carbonic Anhydrase F-box PF00646.28 EWC48023.1 - 0.00036 20.1 0.0 0.00078 19.0 0.0 1.5 1 0 0 1 1 1 1 F-box domain Gly_acyl_tr_N PF06021.6 EWC48023.1 - 0.069 12.5 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 Aralkyl acyl-CoA:amino acid N-acyltransferase F-box-like PF12937.2 EWC48023.1 - 0.11 12.2 0.2 0.23 11.2 0.1 1.5 1 0 0 1 1 1 0 F-box-like DUF3455 PF11937.3 EWC48024.1 - 4.1e-33 114.8 0.5 5e-33 114.5 0.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3455) Dsh_C PF12316.3 EWC48026.1 - 0.17 11.9 2.1 0.25 11.4 1.5 1.1 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal Sulfate_transp PF00916.15 EWC48027.1 - 1.2e-78 263.9 10.2 1.2e-78 263.9 7.1 1.7 2 0 0 2 2 2 1 Sulfate transporter family Sulfate_tra_GLY PF13792.1 EWC48027.1 - 1.1e-31 108.2 3.7 1.1e-31 108.2 2.5 4.0 5 0 0 5 5 5 1 Sulfate transporter N-terminal domain with GLY motif STAS PF01740.16 EWC48027.1 - 1e-06 28.1 0.0 2e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 STAS domain Ribonucleas_3_3 PF14622.1 EWC48028.1 - 1.3e-06 28.3 0.0 2.2e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 Ribonuclease-III-like dsrm PF00035.20 EWC48028.1 - 1.9e-06 28.3 0.0 3.2e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 Double-stranded RNA binding motif Ribonuclease_3 PF00636.21 EWC48028.1 - 2.1e-05 24.9 0.0 5.5e-05 23.5 0.0 1.7 1 1 0 1 1 1 1 Ribonuclease III domain DND1_DSRM PF14709.1 EWC48028.1 - 8.3e-05 22.8 0.0 0.00021 21.4 0.0 1.7 1 1 0 1 1 1 1 double strand RNA binding domain from DEAD END PROTEIN 1 Pentapeptide_2 PF01469.13 EWC48029.1 - 0.0024 17.4 43.5 0.024 14.2 30.1 2.3 1 1 0 1 1 1 1 Pentapeptide repeats (8 copies) APH PF01636.18 EWC48030.1 - 1.8e-43 149.0 0.0 2.6e-43 148.4 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 EWC48030.1 - 3e-08 33.4 0.0 5.1e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase EcKinase PF02958.15 EWC48030.1 - 7.2e-07 28.6 0.0 1.3e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 Ecdysteroid kinase RIO1 PF01163.17 EWC48030.1 - 0.00014 21.2 0.0 0.033 13.5 0.0 2.2 2 0 0 2 2 2 2 RIO1 family DUF1679 PF07914.6 EWC48030.1 - 0.11 11.1 0.0 0.21 10.1 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1679) Ank_2 PF12796.2 EWC48031.1 - 7.7e-16 58.2 0.0 2e-07 31.2 0.0 3.3 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.25 EWC48031.1 - 8.4e-09 34.8 0.3 0.54 10.1 0.0 5.2 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.1 EWC48031.1 - 3.5e-06 27.3 0.0 0.6 10.7 0.0 4.4 2 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 EWC48031.1 - 0.00013 21.8 0.0 4.3 7.8 0.0 4.7 5 0 0 5 5 5 2 Ankyrin repeat FYVE_2 PF02318.11 EWC48032.1 - 0.9 9.4 3.4 1.5 8.7 2.4 1.2 1 0 0 1 1 1 0 FYVE-type zinc finger Sec63 PF02889.11 EWC48033.1 - 5.1e-181 600.8 0.0 4.5e-105 351.3 0.0 2.3 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.24 EWC48033.1 - 7.1e-56 188.3 0.2 4.6e-31 107.5 0.1 3.4 3 0 0 3 3 3 2 DEAD/DEAH box helicase ResIII PF04851.10 EWC48033.1 - 3.4e-18 66.1 0.1 2.7e-09 37.1 0.0 2.5 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.26 EWC48033.1 - 1.7e-10 40.5 0.0 1.5e-09 37.6 0.0 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain AAA_22 PF13401.1 EWC48033.1 - 5e-07 29.9 0.4 0.0045 17.1 0.1 3.3 2 1 0 2 2 2 2 AAA domain PhoH PF02562.11 EWC48033.1 - 7.5e-05 22.0 0.0 0.13 11.5 0.0 3.4 3 0 0 3 3 3 2 PhoH-like protein T2SE PF00437.15 EWC48033.1 - 0.0002 20.3 0.0 0.27 10.0 0.0 2.4 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_10 PF12846.2 EWC48033.1 - 0.00046 19.7 0.0 3.6 6.9 0.0 4.1 4 0 0 4 4 4 2 AAA-like domain FtsK_SpoIIIE PF01580.13 EWC48033.1 - 0.0053 16.2 0.0 0.039 13.4 0.0 2.3 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_19 PF13245.1 EWC48033.1 - 0.0063 16.2 0.0 0.37 10.5 0.0 2.7 2 0 0 2 2 2 1 Part of AAA domain UvrD-helicase PF00580.16 EWC48033.1 - 0.027 13.7 0.0 0.64 9.2 0.0 2.6 3 0 0 3 3 3 0 UvrD/REP helicase N-terminal domain Methyltransf_13 PF08421.6 EWC48035.1 - 0.11 12.0 0.1 1.3 8.5 0.0 2.2 2 0 0 2 2 2 0 Putative zinc binding domain Peptidase_S8 PF00082.17 EWC48036.1 - 1e-31 110.1 1.8 1.5e-31 109.6 1.3 1.3 1 0 0 1 1 1 1 Subtilase family PWWP PF00855.12 EWC48037.1 - 7.5e-09 35.6 0.0 7.5e-09 35.6 0.0 3.3 3 1 0 3 3 3 1 PWWP domain CPSase_L_D2 PF02786.12 EWC48038.1 - 8.4e-111 368.2 0.1 1.7e-84 282.3 0.0 2.4 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_D3 PF02787.14 EWC48038.1 - 4.2e-41 139.5 0.0 1.1e-40 138.2 0.0 1.8 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain ATP-grasp_4 PF13535.1 EWC48038.1 - 1.2e-35 122.9 0.1 6.3e-19 68.4 0.0 2.5 2 0 0 2 2 2 2 ATP-grasp domain CPSase_L_chain PF00289.17 EWC48038.1 - 5.7e-34 116.5 0.0 1.4e-16 60.5 0.0 2.7 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, N-terminal domain ATPgrasp_Ter PF15632.1 EWC48038.1 - 7.5e-25 87.3 0.0 2.7e-08 32.9 0.0 3.8 3 1 0 3 3 3 3 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp PF02222.17 EWC48038.1 - 1.3e-18 66.9 0.0 1.3e-08 34.4 0.0 2.3 2 0 0 2 2 2 2 ATP-grasp domain Dala_Dala_lig_C PF07478.8 EWC48038.1 - 2.1e-14 53.4 0.2 3.9e-06 26.3 0.0 2.5 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus RimK PF08443.6 EWC48038.1 - 3.5e-09 36.4 0.2 0.00015 21.3 0.0 3.0 3 0 0 3 3 3 2 RimK-like ATP-grasp domain GARS_A PF01071.14 EWC48038.1 - 9.7e-05 22.0 0.1 0.5 9.9 0.0 2.5 2 0 0 2 2 2 2 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATP-grasp_5 PF13549.1 EWC48038.1 - 0.00055 19.2 0.1 0.029 13.5 0.0 2.4 2 0 0 2 2 2 1 ATP-grasp domain MGS PF02142.17 EWC48038.1 - 0.014 15.3 0.0 0.045 13.6 0.0 1.9 1 0 0 1 1 1 0 MGS-like domain Epimerase PF01370.16 EWC48038.1 - 0.023 14.1 0.0 0.22 10.9 0.0 2.2 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family CAP_GLY PF01302.20 EWC48040.1 - 2.7e-18 65.4 1.4 5.3e-18 64.4 1.0 1.5 1 0 0 1 1 1 1 CAP-Gly domain CENP-F_leu_zip PF10473.4 EWC48040.1 - 0.0037 17.1 8.2 0.0037 17.1 5.7 4.2 4 0 0 4 4 4 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AAA_13 PF13166.1 EWC48040.1 - 5 5.4 31.6 0.17 10.3 9.4 2.6 1 1 1 2 2 2 0 AAA domain Reo_sigmaC PF04582.7 EWC48040.1 - 9.7 5.2 7.6 7.2 5.6 0.0 2.7 2 2 0 2 2 2 0 Reovirus sigma C capsid protein Sel1 PF08238.7 EWC48041.1 - 3e-17 62.6 11.2 7.8e-06 26.3 0.2 4.3 4 0 0 4 4 4 3 Sel1 repeat Gal-bind_lectin PF00337.17 EWC48042.1 - 3.5e-05 23.1 0.0 5.1e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Galactoside-binding lectin ADH_N PF08240.7 EWC48043.1 - 5e-06 26.2 1.0 9.4e-06 25.3 0.1 1.9 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 EWC48043.1 - 0.005 16.3 0.1 0.0097 15.4 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase SF3b1 PF08920.5 EWC48044.1 - 1.9e-38 131.7 0.3 1.9e-38 131.7 0.2 2.1 1 1 1 2 2 2 2 Splicing factor 3B subunit 1 HEAT_2 PF13646.1 EWC48044.1 - 1.6e-14 53.8 4.4 0.012 15.8 0.0 7.5 6 2 0 7 7 7 4 HEAT repeats HEAT_EZ PF13513.1 EWC48044.1 - 1.4e-09 38.1 5.9 0.29 11.6 0.0 7.9 6 2 2 8 8 8 2 HEAT-like repeat HEAT PF02985.17 EWC48044.1 - 1.7e-09 36.9 6.4 1.9 8.7 0.1 9.1 9 0 0 9 9 9 2 HEAT repeat Vac14_Fab1_bd PF12755.2 EWC48044.1 - 0.00014 22.1 0.6 2.2 8.7 0.0 5.4 6 0 0 6 6 6 1 Vacuolar 14 Fab1-binding region Dopey_N PF04118.9 EWC48044.1 - 0.0077 15.0 0.1 2.4 6.8 0.0 4.0 3 1 2 5 5 5 1 Dopey, N-terminal CLASP_N PF12348.3 EWC48044.1 - 0.038 13.3 0.1 2.2 7.6 0.0 3.2 3 0 0 3 3 3 0 CLASP N terminal DNA_pol_A_exo1 PF01612.15 EWC48045.1 - 5.4e-13 48.8 0.0 1.1e-12 47.8 0.0 1.5 1 1 0 1 1 1 1 3'-5' exonuclease WLM PF08325.5 EWC48046.1 - 1.2e-34 119.8 0.0 2.8e-34 118.6 0.0 1.7 1 1 0 1 1 1 1 WLM domain DUF45 PF01863.12 EWC48046.1 - 0.01 15.6 1.4 0.019 14.7 0.9 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF45 DZR PF12773.2 EWC48046.1 - 0.017 14.9 5.2 0.29 10.9 0.2 2.3 2 0 0 2 2 2 0 Double zinc ribbon GCC2_GCC3 PF07699.8 EWC48046.1 - 0.64 9.6 3.5 0.45 10.1 0.4 2.2 2 0 0 2 2 2 0 GCC2 and GCC3 WD40 PF00400.27 EWC48047.1 - 0.0034 17.2 2.4 0.4 10.6 0.2 3.5 4 0 0 4 4 4 2 WD domain, G-beta repeat Sec66 PF09802.4 EWC48048.1 - 1.2e-56 191.1 0.1 1.4e-56 190.9 0.0 1.1 1 0 0 1 1 1 1 Preprotein translocase subunit Sec66 PEP-utilisers_N PF05524.8 EWC48048.1 - 0.00061 19.5 1.6 0.0011 18.8 1.1 1.4 1 0 0 1 1 1 1 PEP-utilising enzyme, N-terminal PP2C_2 PF13672.1 EWC48049.1 - 4.1e-10 39.4 0.0 6.7e-10 38.7 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C PF00481.16 EWC48049.1 - 1.9e-06 27.4 0.4 0.026 13.9 0.0 2.2 2 0 0 2 2 2 2 Protein phosphatase 2C SpoIIE PF07228.7 EWC48049.1 - 6e-06 26.0 0.3 3.1e-05 23.7 0.1 2.3 3 1 0 3 3 3 1 Stage II sporulation protein E (SpoIIE) DUF3112 PF11309.3 EWC48050.1 - 0.0059 16.4 0.4 0.0077 16.0 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3112) DUF4187 PF13821.1 EWC48051.1 - 2.2e-19 68.7 3.9 4.6e-19 67.7 2.7 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4187) G-patch PF01585.18 EWC48051.1 - 6.1e-07 29.1 0.0 1.4e-06 28.0 0.0 1.6 1 0 0 1 1 1 1 G-patch domain Ribosomal_L10 PF00466.15 EWC48052.1 - 8.5e-23 80.1 0.5 2e-22 78.9 0.2 1.7 2 0 0 2 2 2 1 Ribosomal protein L10 Ribosomal_60s PF00428.14 EWC48052.1 - 8.6e-18 64.5 4.2 8.6e-18 64.5 2.9 2.1 2 0 0 2 2 2 1 60s Acidic ribosomal protein DUF1021 PF06257.6 EWC48052.1 - 0.051 13.2 0.1 0.12 12.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1021) FMN_red PF03358.10 EWC48053.1 - 6e-10 38.8 0.0 8.4e-10 38.3 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.12 EWC48053.1 - 1.5e-09 37.6 0.0 1.8e-09 37.3 0.0 1.1 1 0 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_1 PF00258.20 EWC48053.1 - 7.8e-07 29.1 0.0 1.2e-06 28.5 0.0 1.4 1 0 0 1 1 1 1 Flavodoxin Flavodoxin_5 PF12724.2 EWC48053.1 - 0.021 14.8 0.0 0.063 13.2 0.0 1.8 1 1 1 2 2 2 0 Flavodoxin domain ComC PF03047.9 EWC48053.1 - 0.39 10.1 2.5 16 5.0 0.0 2.8 3 0 0 3 3 3 0 COMC family adh_short PF00106.20 EWC48055.1 - 3.8e-11 43.1 0.4 7.6e-11 42.2 0.1 1.6 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.5 EWC48055.1 - 0.0003 20.4 0.0 0.0005 19.7 0.0 1.3 1 0 0 1 1 1 1 KR domain Shikimate_DH PF01488.15 EWC48055.1 - 0.017 15.2 0.1 0.03 14.4 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NPL4 PF05021.10 EWC48056.1 - 4.6e-120 400.3 0.0 5.8e-120 400.0 0.0 1.1 1 0 0 1 1 1 1 NPL4 family zf-NPL4 PF05020.10 EWC48056.1 - 2e-71 238.3 0.3 2.9e-71 237.8 0.2 1.2 1 0 0 1 1 1 1 NPL4 family, putative zinc binding region UN_NPL4 PF11543.3 EWC48056.1 - 9e-06 25.8 0.0 2.6e-05 24.3 0.0 1.8 1 1 0 1 1 1 1 Nuclear pore localisation protein NPL4 dCMP_cyt_deam_1 PF00383.17 EWC48057.1 - 1.1e-25 89.1 0.0 1.5e-25 88.8 0.0 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region Bd3614-deam PF14439.1 EWC48057.1 - 6.4e-05 22.8 0.4 0.059 13.2 0.1 2.7 1 1 2 3 3 3 2 Bd3614-like deaminase XOO_2897-deam PF14440.1 EWC48057.1 - 0.0011 18.6 0.0 0.0022 17.7 0.0 1.4 1 0 0 1 1 1 1 Xanthomonas XOO_2897-like deaminase MafB19-deam PF14437.1 EWC48057.1 - 0.0087 15.7 0.0 0.014 15.0 0.0 1.3 1 0 0 1 1 1 1 MafB19-like deaminase APOBEC_N PF08210.6 EWC48057.1 - 0.03 13.9 0.0 0.036 13.7 0.0 1.3 1 0 0 1 1 1 0 APOBEC-like N-terminal domain BAH PF01426.13 EWC48058.1 - 1.9e-21 76.0 0.0 4.8e-21 74.7 0.0 1.7 1 0 0 1 1 1 1 BAH domain zf-HC5HC2H_2 PF13832.1 EWC48058.1 - 8.4e-19 67.5 3.8 8.4e-19 67.5 2.7 3.7 4 0 0 4 4 4 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.1 EWC48058.1 - 4.5e-15 55.5 6.3 4.5e-15 55.5 4.4 4.0 4 0 0 4 4 4 1 PHD-like zinc-binding domain PHD PF00628.24 EWC48058.1 - 5.2e-11 42.0 54.9 6e-07 29.0 6.4 6.4 6 1 1 7 7 7 3 PHD-finger PHD_2 PF13831.1 EWC48058.1 - 3e-08 32.8 5.7 3e-08 32.8 4.0 5.6 8 0 0 8 8 8 2 PHD-finger GATA PF00320.22 EWC48058.1 - 0.00082 18.6 10.7 0.036 13.4 0.2 4.3 4 0 0 4 4 4 2 GATA zinc finger Myb_DNA-binding PF00249.26 EWC48058.1 - 0.0034 17.3 0.1 0.0092 16.0 0.1 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Prok-RING_1 PF14446.1 EWC48058.1 - 0.041 13.6 42.6 0.052 13.2 3.9 4.5 4 0 0 4 4 4 0 Prokaryotic RING finger family 1 DUF3584 PF12128.3 EWC48058.1 - 0.06 10.6 5.5 0.11 9.7 3.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) C1_1 PF00130.17 EWC48058.1 - 6.4 6.5 48.3 0.047 13.4 3.8 4.9 6 0 0 6 6 6 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase PF00069.20 EWC48059.1 - 2.4e-33 115.3 0.0 1.8e-32 112.5 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC48059.1 - 2.3e-12 46.5 0.0 4.3e-11 42.3 0.0 2.3 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 EWC48059.1 - 0.0011 18.7 0.0 0.0024 17.6 0.0 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family Methyltransf_11 PF08241.7 EWC48060.1 - 2.5e-09 37.5 0.0 3.9e-09 36.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EWC48060.1 - 4.6e-09 36.1 0.0 8.7e-09 35.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EWC48060.1 - 9.5e-07 29.2 0.0 1.4e-06 28.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EWC48060.1 - 9.8e-07 29.3 0.1 1.5e-06 28.7 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EWC48060.1 - 2.3e-05 23.9 0.0 3.1e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.15 EWC48060.1 - 2.4e-05 23.4 0.0 3.2e-05 23.0 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase MTS PF05175.9 EWC48060.1 - 0.00042 19.7 0.0 0.00065 19.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.14 EWC48060.1 - 0.0027 17.2 0.0 0.0045 16.5 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_32 PF13679.1 EWC48060.1 - 0.019 14.6 0.0 0.03 14.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain DREV PF05219.7 EWC48060.1 - 0.047 12.5 0.0 0.09 11.6 0.0 1.4 2 0 0 2 2 2 0 DREV methyltransferase DnaJ PF00226.26 EWC48061.1 - 2.2e-23 81.7 2.2 3.8e-23 80.9 1.5 1.4 1 0 0 1 1 1 1 DnaJ domain CTDII PF01556.13 EWC48061.1 - 5.7e-20 70.9 0.0 2.2e-17 62.7 0.0 2.6 2 0 0 2 2 2 2 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.14 EWC48061.1 - 2.2e-12 46.8 20.4 4.1e-12 45.9 14.2 1.5 1 0 0 1 1 1 1 DnaJ central domain HypA PF01155.14 EWC48061.1 - 2.5 7.8 10.8 1.1 8.9 1.9 2.3 1 1 1 2 2 2 0 Hydrogenase expression/synthesis hypA family TAP_C PF03943.8 EWC48062.1 - 4.5e-12 45.1 0.1 9.4e-12 44.1 0.0 1.6 1 0 0 1 1 1 1 TAP C-terminal domain LRR_4 PF12799.2 EWC48062.1 - 4.6e-09 35.7 8.8 9.3e-07 28.3 1.2 2.7 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 EWC48062.1 - 0.00048 19.7 0.3 6.2 7.2 0.0 4.0 3 0 0 3 3 3 2 Leucine Rich Repeat UBA_4 PF14555.1 EWC48062.1 - 0.0049 16.3 0.1 0.011 15.2 0.1 1.6 1 0 0 1 1 1 1 UBA-like domain LRR_7 PF13504.1 EWC48062.1 - 0.0075 16.2 0.5 10 6.8 0.1 3.0 2 0 0 2 2 2 2 Leucine rich repeat LRR_8 PF13855.1 EWC48062.1 - 0.012 15.3 0.3 0.028 14.1 0.2 1.7 1 0 0 1 1 1 0 Leucine rich repeat MutS_V PF00488.16 EWC48063.1 - 2.1e-79 266.2 0.0 9e-79 264.1 0.0 2.0 2 0 0 2 2 2 1 MutS domain V MutS_III PF05192.13 EWC48063.1 - 1.5e-34 119.5 0.0 7.8e-34 117.2 0.0 1.9 1 1 0 1 1 1 1 MutS domain III MutS_I PF01624.15 EWC48063.1 - 1.6e-17 63.5 0.0 4.5e-17 62.0 0.0 1.8 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.12 EWC48063.1 - 3.8e-09 36.7 0.0 1.6e-08 34.6 0.0 2.0 1 1 0 1 1 1 1 MutS domain II AAA_23 PF13476.1 EWC48063.1 - 0.018 15.3 1.6 1.1 9.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.1 EWC48063.1 - 0.023 14.6 0.1 0.16 11.9 0.0 2.4 3 0 0 3 3 3 0 AAA domain ABC_tran PF00005.22 EWC48063.1 - 0.024 14.9 0.0 5 7.4 0.0 2.7 2 0 0 2 2 2 0 ABC transporter DUF2828 PF11443.3 EWC48063.1 - 0.031 12.5 0.4 0.043 12.0 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) MutS_IV PF05190.13 EWC48063.1 - 0.038 14.1 0.0 0.089 12.9 0.0 1.5 1 0 0 1 1 1 0 MutS family domain IV Mito_fiss_reg PF05308.6 EWC48064.1 - 0.94 8.7 23.7 0.12 11.7 3.4 3.0 2 1 1 3 3 3 0 Mitochondrial fission regulator Dicty_REP PF05086.7 EWC48064.1 - 1.7 6.2 7.0 2.3 5.8 4.9 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein EB PF01683.13 EWC48065.1 - 0.032 14.2 59.1 0.2 11.7 1.9 6.2 2 2 3 6 6 6 0 EB module zf-CCHH PF10283.4 EWC48065.1 - 1.1 9.1 6.1 52 3.7 0.1 3.4 3 0 0 3 3 3 0 Zinc-finger (CX5CX6HX5H) motif Stig1 PF04885.8 EWC48065.1 - 5.8 7.1 42.4 4.6 7.4 5.7 3.2 3 0 0 3 3 3 0 Stigma-specific protein, Stig1 DUF1403 PF07183.6 EWC48066.1 - 0.048 13.0 0.1 0.064 12.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1403) URO-D PF01208.12 EWC48067.1 - 8e-128 426.1 0.0 9e-128 425.9 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) Peptidase_S9 PF00326.16 EWC48068.1 - 1.3e-54 184.6 0.1 2.3e-54 183.8 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 EWC48068.1 - 1.4e-14 54.1 0.0 2.9e-14 53.0 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 EWC48068.1 - 4.3e-06 26.7 0.0 3.6e-05 23.7 0.0 2.4 2 1 0 2 2 2 1 Alpha/beta hydrolase family PD40 PF07676.7 EWC48068.1 - 0.014 15.0 1.5 1.2 8.8 0.1 3.0 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat AXE1 PF05448.7 EWC48068.1 - 0.026 13.0 0.3 0.12 10.8 0.1 1.8 1 1 1 2 2 2 0 Acetyl xylan esterase (AXE1) Peptidase_S9_N PF02897.10 EWC48068.1 - 0.043 12.3 0.1 0.069 11.7 0.1 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase, N-terminal beta-propeller domain DUF2920 PF11144.3 EWC48068.1 - 0.056 12.4 0.0 1.4 7.8 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2920) Epimerase PF01370.16 EWC48070.1 - 1e-55 188.7 0.0 1.3e-55 188.4 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.10 EWC48070.1 - 3.4e-23 81.9 0.0 5.5e-22 78.0 0.0 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.7 EWC48070.1 - 3.5e-21 75.2 0.1 3.1e-20 72.1 0.1 2.1 1 1 0 1 1 1 1 Male sterility protein 3Beta_HSD PF01073.14 EWC48070.1 - 2.1e-19 69.3 0.0 2.5e-19 69.0 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.12 EWC48070.1 - 6.7e-19 67.8 0.0 9.4e-19 67.3 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.1 EWC48070.1 - 2.5e-06 27.6 0.0 4.9e-06 26.6 0.0 1.5 1 1 0 1 1 1 1 NADH(P)-binding adh_short PF00106.20 EWC48070.1 - 0.0049 16.8 0.0 0.059 13.2 0.0 2.1 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.5 EWC48070.1 - 0.071 12.7 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 KR domain WD40 PF00400.27 EWC48071.1 - 1.5e-32 110.2 30.7 5.9e-13 48.1 0.3 7.9 9 0 0 9 9 9 4 WD domain, G-beta repeat NACHT PF05729.7 EWC48071.1 - 4e-23 81.8 0.0 7.8e-23 80.9 0.0 1.5 1 0 0 1 1 1 1 NACHT domain Nbas_N PF15492.1 EWC48071.1 - 0.0075 15.4 3.8 15 4.5 0.0 5.0 3 1 2 5 5 5 1 Neuroblastoma-amplified sequence, N terminal CDtoxinA PF03498.9 EWC48071.1 - 0.016 14.5 0.8 2.6 7.4 0.0 3.2 1 1 2 3 3 3 0 Cytolethal distending toxin A/C family Nucleoporin_N PF08801.6 EWC48071.1 - 0.087 11.5 11.6 0.15 10.7 2.3 3.4 2 1 1 3 3 3 0 Nup133 N terminal like AAA_19 PF13245.1 EWC48071.1 - 0.093 12.4 0.0 0.41 10.4 0.0 2.1 1 0 0 1 1 1 0 Part of AAA domain Sec5 PF15469.1 EWC48071.1 - 0.25 11.0 1.8 7.6 6.2 0.3 2.6 2 1 1 3 3 3 0 Exocyst complex component Sec5 zf-CCCH PF00642.19 EWC48072.1 - 4.6e-17 61.2 37.9 4.1e-05 23.1 0.3 5.6 5 1 1 6 6 6 5 Zinc finger C-x8-C-x5-C-x3-H type (and similar) LUC7 PF03194.10 EWC48072.1 - 0.1 12.1 2.9 7.2 6.0 0.3 2.5 2 0 0 2 2 2 0 LUC7 N_terminus zf-CCCH_2 PF14608.1 EWC48072.1 - 0.28 11.2 45.4 0.33 11.0 0.7 5.8 6 1 0 6 6 6 0 Zinc finger C-x8-C-x5-C-x3-H type LRV_FeS PF05484.6 EWC48072.1 - 0.28 10.7 17.9 1.4 8.5 0.1 4.5 3 2 2 5 5 5 0 LRV protein FeS4 cluster Lustrin_cystein PF14625.1 EWC48072.1 - 7.8 6.6 17.4 46 4.1 0.1 3.8 3 1 0 3 3 3 0 Lustrin, cysteine-rich repeated domain Vps53_N PF04100.7 EWC48073.1 - 1.7e-103 346.3 0.9 3e-103 345.5 0.1 1.7 2 0 0 2 2 2 1 Vps53-like, N-terminal DUF2450 PF10475.4 EWC48073.1 - 7.4e-05 21.7 2.7 7.4e-05 21.7 1.9 1.6 2 0 0 2 2 2 1 Protein of unknown function N-terminal domain (DUF2450) DUF2451 PF10474.4 EWC48073.1 - 0.00062 19.5 0.3 0.0066 16.2 0.1 2.2 2 0 0 2 2 2 1 Protein of unknown function C-terminus (DUF2451) DUF1024 PF06260.7 EWC48073.1 - 0.049 13.7 0.0 0.23 11.6 0.0 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1024) Vac_Fusion PF02346.11 EWC48075.1 - 0.0063 15.9 1.3 0.026 13.9 0.0 2.4 2 0 0 2 2 2 1 Chordopoxvirus fusion protein DUF632 PF04782.7 EWC48075.1 - 0.039 13.0 1.8 0.083 11.9 0.4 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF632) COG5 PF10392.4 EWC48075.1 - 0.087 12.7 5.0 0.92 9.4 0.4 2.5 1 1 1 2 2 2 0 Golgi transport complex subunit 5 MitMem_reg PF13012.1 EWC48075.1 - 0.12 12.4 1.9 0.76 9.8 0.2 2.4 1 1 1 2 2 2 0 Maintenance of mitochondrial structure and function Reo_sigmaC PF04582.7 EWC48075.1 - 0.2 10.8 5.5 0.5 9.4 3.5 1.6 1 1 0 1 1 1 0 Reovirus sigma C capsid protein FlaC_arch PF05377.6 EWC48075.1 - 0.26 11.2 4.3 1.5 8.8 0.3 3.1 1 1 2 3 3 3 0 Flagella accessory protein C (FlaC) CENP-F_leu_zip PF10473.4 EWC48075.1 - 0.33 10.8 0.0 0.33 10.8 0.0 2.8 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF3359 PF11839.3 EWC48075.1 - 0.55 10.6 3.6 0.78 10.1 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3359) DUF1664 PF07889.7 EWC48075.1 - 0.7 9.6 3.5 2.4 7.9 2.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF948 PF06103.6 EWC48075.1 - 0.75 9.6 4.2 1.4 8.8 1.1 2.3 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) MCPsignal PF00015.16 EWC48075.1 - 1.5 8.2 7.8 0.21 11.0 2.4 1.7 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Fib_alpha PF08702.5 EWC48075.1 - 2.3 8.3 6.6 0.91 9.6 2.2 2.0 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DEAD PF00270.24 EWC48077.1 - 7.9e-43 145.8 4.0 8.4e-43 145.7 1.4 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EWC48077.1 - 9.2e-28 95.9 0.1 6.6e-27 93.1 0.2 2.3 2 1 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 EWC48077.1 - 0.00061 19.6 0.3 0.0017 18.1 0.2 1.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.1 EWC48077.1 - 0.0016 18.0 0.4 0.0042 16.6 0.3 1.7 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.1 EWC48077.1 - 0.0051 16.9 0.3 0.019 15.1 0.2 2.0 1 1 0 1 1 1 1 AAA domain Flavi_DEAD PF07652.9 EWC48077.1 - 0.006 16.3 0.3 0.028 14.1 0.2 2.0 1 1 0 1 1 1 1 Flavivirus DEAD domain AAA_19 PF13245.1 EWC48077.1 - 0.0084 15.8 0.1 0.021 14.5 0.1 1.6 1 0 0 1 1 1 1 Part of AAA domain Helicase_RecD PF05127.9 EWC48077.1 - 0.023 14.3 0.1 0.046 13.3 0.0 1.6 2 0 0 2 2 2 0 Helicase CMS1 PF14617.1 EWC48077.1 - 0.05 12.6 0.1 0.19 10.7 0.0 1.9 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit Fanconi_A PF03511.9 EWC48077.1 - 0.05 13.3 0.1 0.1 12.3 0.1 1.5 1 0 0 1 1 1 0 Fanconi anaemia group A protein PhoH PF02562.11 EWC48077.1 - 0.067 12.4 1.9 0.1 11.8 0.2 2.0 2 0 0 2 2 2 0 PhoH-like protein MatE PF01554.13 EWC48078.1 - 8.6e-06 25.4 26.6 0.0002 21.0 6.2 3.4 3 0 0 3 3 3 3 MatE Polysacc_synt_C PF14667.1 EWC48078.1 - 0.0003 20.6 4.0 0.0003 20.6 2.8 3.1 3 2 0 3 3 3 1 Polysaccharide biosynthesis C-terminal domain RTX PF02382.10 EWC48078.1 - 0.45 8.7 3.3 0.65 8.1 2.3 1.1 1 0 0 1 1 1 0 RTX N-terminal domain WD40 PF00400.27 EWC48079.1 - 2.4e-27 93.7 18.0 2e-06 27.4 0.2 6.1 6 0 0 6 6 6 4 WD domain, G-beta repeat NST1 PF13945.1 EWC48079.1 - 0.023 14.7 7.0 0.19 11.7 0.7 2.2 2 0 0 2 2 2 0 Salt tolerance down-regulator SRP72 PF08492.7 EWC48079.1 - 0.027 14.8 6.6 0.47 10.8 1.4 2.4 2 0 0 2 2 2 0 SRP72 RNA-binding domain Protocadherin PF08374.6 EWC48079.1 - 0.48 10.0 5.7 4.8 6.7 1.2 2.3 2 0 0 2 2 2 0 Protocadherin DUF1754 PF08555.5 EWC48079.1 - 3.9 8.1 22.6 0.46 11.1 5.9 2.9 3 0 0 3 3 3 0 Eukaryotic family of unknown function (DUF1754) FLO_LFY PF01698.11 EWC48079.1 - 6.7 5.4 7.3 1.7 7.4 2.6 1.7 2 0 0 2 2 2 0 Floricaula / Leafy protein DUF1776 PF08643.5 EWC48080.1 - 1.7e-79 267.1 0.0 2e-79 266.8 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) DUF2706 PF10913.3 EWC48080.1 - 0.033 13.7 0.0 0.064 12.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2706) Herpes_gE PF02480.11 EWC48080.1 - 0.16 10.2 0.0 0.23 9.6 0.0 1.1 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E CHAT PF12770.2 EWC48082.1 - 4.5e-32 111.3 0.1 9.1e-32 110.3 0.1 1.5 1 0 0 1 1 1 1 CHAT domain wnt PF00110.14 EWC48082.1 - 0.17 11.0 0.1 6.8 5.7 0.0 3.0 3 1 0 4 4 4 0 wnt family PCI PF01399.22 EWC48083.1 - 2.5e-15 56.6 0.8 6.1e-15 55.4 0.0 2.0 2 1 0 2 2 2 1 PCI domain CPSase_L_D2 PF02786.12 EWC48084.1 - 3.2e-71 238.9 0.0 6e-71 238.0 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_chain PF00289.17 EWC48084.1 - 5.9e-36 122.9 0.0 1.4e-35 121.7 0.0 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, N-terminal domain Biotin_carb_C PF02785.14 EWC48084.1 - 5.9e-36 122.7 0.0 1.5e-35 121.4 0.0 1.7 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain ATP-grasp_4 PF13535.1 EWC48084.1 - 1.2e-16 60.9 0.0 2.4e-16 60.0 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl PF00364.17 EWC48084.1 - 3.7e-15 55.3 0.1 8.9e-15 54.0 0.1 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme ATPgrasp_Ter PF15632.1 EWC48084.1 - 2.4e-10 39.7 0.0 6.6e-10 38.2 0.0 1.6 1 1 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon Dala_Dala_lig_C PF07478.8 EWC48084.1 - 5.9e-09 35.6 0.0 1.6e-08 34.2 0.0 1.6 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus Biotin_lipoyl_2 PF13533.1 EWC48084.1 - 6.5e-06 25.7 0.0 5e-05 22.8 0.0 2.2 1 1 1 2 2 2 1 Biotin-lipoyl like RimK PF08443.6 EWC48084.1 - 0.0035 16.8 0.0 0.014 14.9 0.0 1.8 2 0 0 2 2 2 1 RimK-like ATP-grasp domain GARS_A PF01071.14 EWC48084.1 - 0.0038 16.8 0.0 0.0063 16.1 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATP-grasp_3 PF02655.9 EWC48084.1 - 0.0091 15.8 0.0 0.022 14.6 0.0 1.7 1 0 0 1 1 1 1 ATP-grasp domain GCV_H PF01597.14 EWC48084.1 - 0.062 12.9 0.0 0.16 11.6 0.0 1.6 1 0 0 1 1 1 0 Glycine cleavage H-protein HlyD_2 PF12700.2 EWC48084.1 - 0.19 10.8 0.0 0.63 9.1 0.0 1.7 1 1 1 2 2 2 0 HlyD family secretion protein MARVEL PF01284.18 EWC48086.1 - 1.5e-08 34.5 11.0 1.5e-07 31.3 7.1 2.1 1 1 1 2 2 2 2 Membrane-associating domain DUF2189 PF09955.4 EWC48086.1 - 0.00072 19.4 3.7 0.0011 18.8 2.6 1.3 1 1 0 1 1 1 1 Predicted integral membrane protein (DUF2189) MARVEL PF01284.18 EWC48087.1 - 2.5e-13 50.0 11.6 3.5e-13 49.5 8.1 1.1 1 0 0 1 1 1 1 Membrane-associating domain Permease PF02405.11 EWC48087.1 - 2 7.8 7.9 0.4 10.1 2.7 1.9 2 1 0 2 2 2 0 Permease Bax1-I PF01027.15 EWC48088.1 - 1e-55 188.5 27.5 1.2e-55 188.3 19.1 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 Imm28 PF15574.1 EWC48088.1 - 0.12 11.9 0.1 0.2 11.1 0.0 1.4 1 0 0 1 1 1 0 Immunity protein 28 COesterase PF00135.23 EWC48090.1 - 7.1e-101 338.5 0.0 9.2e-101 338.1 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 EWC48090.1 - 2.8e-10 40.1 0.0 1.8e-09 37.5 0.0 2.2 2 1 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EWC48090.1 - 0.012 15.3 0.5 1.1 8.9 0.1 2.4 2 0 0 2 2 2 0 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 EWC48090.1 - 0.017 14.3 0.1 0.031 13.5 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family SH3_9 PF14604.1 EWC48091.1 - 2.3e-13 49.4 0.1 4e-13 48.7 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 EWC48091.1 - 1.8e-12 46.4 0.0 3.5e-12 45.4 0.0 1.5 1 0 0 1 1 1 1 SH3 domain BAR PF03114.13 EWC48091.1 - 2.9e-08 33.4 0.4 4.6e-08 32.8 0.3 1.3 1 0 0 1 1 1 1 BAR domain SH3_2 PF07653.12 EWC48091.1 - 1.2e-07 31.1 0.0 2e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain PspA_IM30 PF04012.7 EWC48091.1 - 0.0013 18.1 0.0 0.0052 16.1 0.0 1.9 1 1 0 1 1 1 1 PspA/IM30 family THOC7 PF05615.8 EWC48091.1 - 0.037 14.3 0.2 0.73 10.1 0.1 2.5 2 1 0 2 2 2 0 Tho complex subunit 7 Seryl_tRNA_N PF02403.17 EWC48091.1 - 0.13 12.3 2.2 1.8 8.5 0.0 2.8 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DDHD PF02862.12 EWC48091.1 - 0.44 10.3 5.2 0.44 10.3 0.0 2.1 2 0 0 2 2 2 0 DDHD domain PUL PF08324.6 EWC48092.1 - 5.1e-37 127.1 0.0 6.7e-37 126.7 0.0 1.2 1 0 0 1 1 1 1 PUL domain PFU PF09070.6 EWC48092.1 - 1.8e-36 124.6 0.1 3.4e-36 123.7 0.1 1.5 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) WD40 PF00400.27 EWC48092.1 - 1.3e-34 116.8 21.6 6.2e-06 25.8 0.1 7.4 7 0 0 7 7 7 6 WD domain, G-beta repeat BBS2_Mid PF14783.1 EWC48092.1 - 0.00045 19.9 0.0 0.024 14.4 0.0 3.1 3 0 0 3 3 3 1 Ciliary BBSome complex subunit 2, middle region Septin PF00735.13 EWC48093.1 - 1.9e-108 361.7 0.0 3.8e-108 360.8 0.0 1.4 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.18 EWC48093.1 - 0.00022 21.1 0.0 0.00042 20.2 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 EWC48093.1 - 0.00061 19.2 0.0 0.013 14.9 0.0 2.2 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain DUF258 PF03193.11 EWC48093.1 - 0.00062 18.9 0.1 0.0014 17.8 0.1 1.6 1 1 0 1 1 1 1 Protein of unknown function, DUF258 Dynamin_N PF00350.18 EWC48093.1 - 0.00076 19.3 4.7 0.42 10.4 0.0 3.0 2 1 1 3 3 3 2 Dynamin family AIG1 PF04548.11 EWC48093.1 - 0.0025 16.9 0.0 0.0049 16.0 0.0 1.5 1 0 0 1 1 1 1 AIG1 family Miro PF08477.8 EWC48093.1 - 0.011 16.2 0.0 0.035 14.6 0.0 1.8 1 0 0 1 1 1 0 Miro-like protein AAA_22 PF13401.1 EWC48093.1 - 0.039 14.0 0.0 0.15 12.1 0.0 2.0 1 1 0 1 1 1 0 AAA domain DUF3653 PF12375.3 EWC48093.1 - 0.29 11.3 1.8 5.5 7.2 0.6 2.5 2 0 0 2 2 2 0 Phage protein AAA_17 PF13207.1 EWC48093.1 - 2.3 9.0 6.9 0.8 10.5 0.1 2.9 2 2 0 2 2 2 0 AAA domain AAA_23 PF13476.1 EWC48093.1 - 3.2 8.0 8.0 12 6.1 5.0 2.1 2 0 0 2 2 2 0 AAA domain TPD52 PF04201.10 EWC48093.1 - 8.1 6.1 8.7 15 5.2 6.1 1.4 1 0 0 1 1 1 0 Tumour protein D52 family WD40 PF00400.27 EWC48094.1 - 2e-39 132.0 18.8 1.8e-10 40.2 0.0 6.5 7 0 0 7 7 7 5 WD domain, G-beta repeat Proteasome_A_N PF10584.4 EWC48094.1 - 0.0054 16.0 0.2 2.1 7.7 0.0 3.4 3 0 0 3 3 3 1 Proteasome subunit A N-terminal signature Cytochrom_D1 PF02239.11 EWC48094.1 - 0.092 11.0 0.1 1.6 6.9 0.0 2.2 2 0 0 2 2 2 0 Cytochrome D1 heme domain Nucleoporin_N PF08801.6 EWC48094.1 - 0.11 11.2 0.1 10 4.7 0.0 2.4 1 1 0 2 2 2 0 Nup133 N terminal like Ank_5 PF13857.1 EWC48095.1 - 0.001 19.2 0.1 0.0022 18.1 0.1 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 EWC48095.1 - 0.14 12.4 0.1 0.41 11.0 0.0 1.8 1 0 0 1 1 1 0 Ankyrin repeat RRM_1 PF00076.17 EWC48096.1 - 1.8e-16 59.5 0.0 4.5e-16 58.2 0.0 1.7 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EWC48096.1 - 9.4e-12 44.7 0.0 1.7e-11 43.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EWC48096.1 - 9.6e-06 25.3 0.0 2e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 EWC48097.1 - 7.2e-18 63.9 0.0 2e-11 43.3 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EWC48097.1 - 1e-10 41.4 0.0 1.8e-05 24.6 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Response_reg PF00072.19 EWC48098.1 - 1.4e-18 66.9 0.1 5.6e-12 45.6 0.0 2.4 2 0 0 2 2 2 2 Response regulator receiver domain DUF3439 PF11921.3 EWC48098.1 - 0.00084 19.0 3.6 0.00084 19.0 2.5 2.2 3 0 0 3 3 3 1 Domain of unknown function (DUF3439) Hid1 PF12722.2 EWC48098.1 - 0.22 9.1 4.2 0.32 8.6 2.9 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein BAF1_ABF1 PF04684.8 EWC48098.1 - 0.29 9.9 16.0 0.43 9.3 11.1 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF3987 PF13148.1 EWC48098.1 - 2.7 6.4 8.3 1.6 7.1 4.5 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) Zip PF02535.17 EWC48098.1 - 4.8 6.0 3.7 7.8 5.4 2.5 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Plasmodium_Vir PF05795.6 EWC48098.1 - 5.3 6.1 4.1 9.6 5.2 2.8 1.3 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Ribosomal_S16 PF00886.14 EWC48100.1 - 3.6e-25 87.4 0.1 6.3e-25 86.6 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S16 PRP38 PF03371.10 EWC48101.1 - 1.1e-63 213.9 0.2 1.2e-63 213.8 0.2 1.0 1 0 0 1 1 1 1 PRP38 family Isy1 PF06246.7 EWC48102.1 - 1.3e-84 283.5 6.5 6.3e-84 281.3 4.5 1.8 1 1 0 1 1 1 1 Isy1-like splicing family CCDC-167 PF15188.1 EWC48102.1 - 0.0061 16.4 0.0 0.015 15.1 0.0 1.6 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 167 YolD PF08863.5 EWC48102.1 - 0.017 14.9 0.1 0.03 14.1 0.0 1.4 1 0 0 1 1 1 0 YolD-like protein MMR_HSR1 PF01926.18 EWC48103.1 - 2.3e-13 50.1 0.0 4.4e-13 49.1 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase IIGP PF05049.8 EWC48103.1 - 1.1e-05 24.4 0.0 1.6e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) FeoB_N PF02421.13 EWC48103.1 - 4.3e-05 22.8 0.1 7.4e-05 22.0 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B DUF258 PF03193.11 EWC48103.1 - 0.00044 19.4 0.0 0.00074 18.7 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 ArgK PF03308.11 EWC48103.1 - 0.0062 15.3 0.1 0.0093 14.7 0.1 1.3 1 0 0 1 1 1 1 ArgK protein AAA_29 PF13555.1 EWC48103.1 - 0.034 13.6 0.1 0.072 12.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AIG1 PF04548.11 EWC48103.1 - 0.046 12.8 0.0 0.078 12.0 0.0 1.4 1 0 0 1 1 1 0 AIG1 family AAA_18 PF13238.1 EWC48103.1 - 0.083 13.2 0.5 0.22 11.8 0.1 1.9 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.18 EWC48103.1 - 0.085 12.6 0.3 2.2 8.0 0.0 2.5 1 1 1 2 2 2 0 Dynamin family AAA_16 PF13191.1 EWC48103.1 - 0.11 12.5 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain DAP3 PF10236.4 EWC48103.1 - 0.12 11.2 0.0 0.18 10.7 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 HCO3_cotransp PF00955.16 EWC48104.1 - 2.2e-61 208.0 11.8 9.2e-34 116.9 0.2 2.0 1 1 1 2 2 2 2 HCO3- transporter family DUF1212 PF06738.7 EWC48104.1 - 9.6 5.6 13.7 0.32 10.4 1.6 3.2 4 0 0 4 4 4 0 Protein of unknown function (DUF1212) Metallophos PF00149.23 EWC48105.1 - 8.7e-08 31.7 0.4 2.3e-07 30.4 0.3 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 EWC48105.1 - 0.00024 20.9 2.2 0.00032 20.5 1.5 1.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain DUF4337 PF14235.1 EWC48105.1 - 0.05 13.4 2.2 0.19 11.5 0.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) CDC45 PF02724.9 EWC48105.1 - 0.63 8.0 7.1 0.9 7.4 4.9 1.1 1 0 0 1 1 1 0 CDC45-like protein YqfQ PF14181.1 EWC48105.1 - 2.7 8.0 8.1 4.9 7.1 5.6 1.4 1 0 0 1 1 1 0 YqfQ-like protein Pkinase PF00069.20 EWC48106.1 - 1.8e-59 200.9 0.0 2.6e-59 200.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC48106.1 - 9.5e-27 93.6 0.0 2.1e-26 92.5 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EWC48106.1 - 0.00017 20.6 0.0 0.00095 18.2 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Nop53 PF07767.6 EWC48106.1 - 0.028 13.4 0.2 0.056 12.4 0.1 1.4 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Preseq_ALAS PF09029.5 EWC48106.1 - 0.077 13.0 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 5-aminolevulinate synthase presequence DUF2052 PF09747.4 EWC48107.1 - 1e-22 80.9 12.3 1.2e-22 80.6 8.5 1.1 1 0 0 1 1 1 1 Coiled-coil domain containing protein (DUF2052) WD40 PF00400.27 EWC48108.1 - 4.5e-12 45.3 1.0 1.9e-05 24.3 0.0 3.9 4 0 0 4 4 4 2 WD domain, G-beta repeat Apc4_WD40 PF12894.2 EWC48108.1 - 0.067 12.7 0.0 1.2 8.6 0.0 2.9 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain IKI3 PF04762.7 EWC48108.1 - 0.14 9.9 0.0 2.9 5.5 0.0 2.1 1 1 1 2 2 2 0 IKI3 family Nbas_N PF15492.1 EWC48108.1 - 0.15 11.1 0.0 1.9 7.5 0.0 2.3 1 1 2 3 3 3 0 Neuroblastoma-amplified sequence, N terminal DLIC PF05783.6 EWC48109.1 - 4.2e-44 151.0 0.0 1.1e-37 129.8 0.0 2.9 3 0 0 3 3 3 2 Dynein light intermediate chain (DLIC) RabGAP-TBC PF00566.13 EWC48110.1 - 8.7e-49 165.8 0.0 1.6e-48 165.0 0.0 1.5 1 0 0 1 1 1 1 Rab-GTPase-TBC domain GRAM PF02893.15 EWC48110.1 - 3.2e-10 39.3 0.0 8.2e-10 38.0 0.0 1.7 1 0 0 1 1 1 1 GRAM domain EF-hand_7 PF13499.1 EWC48110.1 - 0.002 18.2 0.5 0.002 18.2 0.3 2.6 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.1 EWC48110.1 - 0.0021 17.7 3.7 0.013 15.3 0.1 3.7 5 0 0 5 5 5 1 EF-hand domain EF-hand_5 PF13202.1 EWC48110.1 - 0.0085 15.3 0.4 0.03 13.6 0.2 2.0 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.27 EWC48110.1 - 0.022 14.0 1.6 0.089 12.1 0.3 2.7 2 0 0 2 2 2 0 EF hand DUF3958 PF13125.1 EWC48110.1 - 0.18 11.7 2.0 0.24 11.3 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3958) Filament PF00038.16 EWC48111.1 - 1.1e-06 28.3 20.5 2.2e-06 27.4 14.2 1.4 1 0 0 1 1 1 1 Intermediate filament protein EF-hand_7 PF13499.1 EWC48111.1 - 0.00092 19.3 1.4 0.0047 17.0 0.0 2.5 2 0 0 2 2 2 1 EF-hand domain pair GAS PF13851.1 EWC48111.1 - 0.0033 16.6 10.4 0.0033 16.6 7.2 2.7 1 1 1 2 2 2 1 Growth-arrest specific micro-tubule binding TIP120 PF08623.5 EWC48111.1 - 0.021 14.3 1.1 0.043 13.4 0.8 1.4 1 0 0 1 1 1 0 TATA-binding protein interacting (TIP20) IncA PF04156.9 EWC48111.1 - 0.084 12.4 37.7 0.012 15.2 9.7 4.0 3 1 1 4 4 4 0 IncA protein AAA_13 PF13166.1 EWC48111.1 - 0.091 11.2 20.4 0.45 8.9 14.3 1.8 1 1 0 1 1 1 0 AAA domain EF-hand_6 PF13405.1 EWC48111.1 - 0.18 11.7 1.6 0.57 10.2 0.6 2.3 2 0 0 2 2 2 0 EF-hand domain DivIC PF04977.10 EWC48111.1 - 0.23 10.9 24.4 0.39 10.2 0.6 4.9 1 1 1 4 4 4 0 Septum formation initiator DUF4200 PF13863.1 EWC48111.1 - 0.57 10.1 33.5 0.28 11.1 13.3 2.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) TPR_MLP1_2 PF07926.7 EWC48111.1 - 0.67 9.6 27.3 0.046 13.4 7.3 3.3 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein NPV_P10 PF05531.7 EWC48111.1 - 0.77 10.0 4.7 0.96 9.7 0.6 2.8 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Atg14 PF10186.4 EWC48111.1 - 2 7.2 26.7 0.21 10.5 3.7 2.4 1 1 1 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 CCDC155 PF14662.1 EWC48111.1 - 2 7.9 32.2 1.1 8.8 10.3 3.0 2 1 1 3 3 3 0 Coiled-coil region of CCDC155 Spc7 PF08317.6 EWC48111.1 - 3.9 6.0 25.5 2.6 6.6 9.7 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein Exo_endo_phos PF03372.18 EWC48112.1 - 7.3e-13 49.0 4.2 1.3e-12 48.1 2.9 1.5 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family ATG27 PF09451.5 EWC48113.1 - 0.007 15.6 0.0 0.01 15.0 0.0 1.3 1 0 0 1 1 1 1 Autophagy-related protein 27 K_trans PF02705.11 EWC48113.1 - 0.045 12.1 0.1 0.06 11.7 0.1 1.1 1 0 0 1 1 1 0 K+ potassium transporter Corona_S2 PF01601.11 EWC48113.1 - 0.49 8.4 3.6 0.74 7.8 2.5 1.2 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein LCAT PF02450.10 EWC48115.1 - 2.3e-97 326.4 0.1 3.3e-97 325.9 0.1 1.2 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase DUF2407_C PF13373.1 EWC48115.1 - 0.084 12.7 0.1 0.22 11.4 0.0 1.7 2 0 0 2 2 2 0 DUF2407 C-terminal domain zf-C3H1 PF10650.4 EWC48116.1 - 2.9e-09 36.2 2.1 4.5e-09 35.6 1.4 1.3 1 0 0 1 1 1 1 Putative zinc-finger domain Med8 PF10232.4 EWC48117.1 - 7.6e-32 110.6 0.7 7.6e-32 110.6 0.5 1.8 2 0 0 2 2 2 1 Mediator of RNA polymerase II transcription complex subunit 8 Nop14 PF04147.7 EWC48117.1 - 0.015 13.2 3.3 0.016 13.1 2.3 1.2 1 0 0 1 1 1 0 Nop14-like family Drc1-Sld2 PF11719.3 EWC48117.1 - 0.045 12.8 0.6 0.051 12.6 0.4 1.1 1 0 0 1 1 1 0 DNA replication and checkpoint protein NOA36 PF06524.7 EWC48117.1 - 0.97 8.6 8.5 1.3 8.1 5.9 1.1 1 0 0 1 1 1 0 NOA36 protein PBP1_TM PF14812.1 EWC48117.1 - 3.5 7.9 11.4 4 7.8 7.3 1.5 1 1 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Nucleoplasmin PF03066.10 EWC48117.1 - 4 6.9 7.9 6.1 6.3 5.5 1.2 1 0 0 1 1 1 0 Nucleoplasmin CDC45 PF02724.9 EWC48117.1 - 6.7 4.6 9.1 8.5 4.2 6.3 1.1 1 0 0 1 1 1 0 CDC45-like protein Myosin_head PF00063.16 EWC48118.1 - 6.6e-249 827.5 1.6 6.6e-249 827.5 1.1 3.4 4 0 0 4 4 4 1 Myosin head (motor domain) Myosin_tail_1 PF01576.14 EWC48118.1 - 1.5e-28 99.0 292.0 6.7e-21 73.7 84.9 6.6 2 2 2 4 4 4 4 Myosin tail Myosin_N PF02736.14 EWC48118.1 - 1e-06 28.2 2.1 2.2e-06 27.2 1.5 1.6 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain AAA_19 PF13245.1 EWC48118.1 - 0.05 13.3 0.0 0.25 11.0 0.0 2.3 1 0 0 1 1 1 0 Part of AAA domain Ferrochelatase PF00762.14 EWC48119.1 - 7.8e-98 327.3 0.0 9.1e-98 327.1 0.0 1.0 1 0 0 1 1 1 1 Ferrochelatase Acyl-CoA_dh_1 PF00441.19 EWC48120.1 - 6.1e-41 140.0 1.7 6.1e-41 140.0 1.2 2.2 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.11 EWC48120.1 - 7.3e-32 110.2 0.1 2e-31 108.9 0.1 1.8 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.14 EWC48120.1 - 4.2e-20 71.0 0.5 1e-19 69.7 0.4 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.6 EWC48120.1 - 4.6e-15 56.0 1.1 4.6e-15 56.0 0.8 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain DUF3988 PF13149.1 EWC48120.1 - 0.034 13.6 0.0 0.051 13.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3988) HpaB_N PF11794.3 EWC48120.1 - 0.13 11.6 0.3 0.79 9.0 0.2 2.1 1 1 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase N terminal Carboxyl_trans PF01039.17 EWC48121.1 - 1.8e-147 491.6 2.3 2.2e-147 491.3 1.6 1.1 1 0 0 1 1 1 1 Carboxyl transferase domain MdcE PF06833.6 EWC48121.1 - 4.9e-05 22.6 0.3 0.22 10.6 0.0 2.3 2 0 0 2 2 2 2 Malonate decarboxylase gamma subunit (MdcE) Peptidase_S8 PF00082.17 EWC48122.1 - 4.3e-55 186.8 8.8 5.8e-55 186.4 6.1 1.1 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.11 EWC48122.1 - 4.1e-15 56.0 0.0 1e-14 54.8 0.0 1.7 1 1 0 1 1 1 1 Peptidase inhibitor I9 Abhydrolase_1 PF00561.15 EWC48123.1 - 2.1e-19 70.0 0.0 5.3e-19 68.6 0.0 1.7 1 1 1 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 EWC48123.1 - 8.9e-11 42.0 2.8 6e-10 39.3 1.8 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.15 EWC48123.1 - 1.7e-05 24.3 0.0 3.1e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Putative esterase Gly_transf_sug PF04488.10 EWC48124.1 - 1.6e-13 50.9 0.0 3.3e-13 49.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Beach PF02138.13 EWC48126.1 - 1.6e-110 368.7 0.0 2.9e-110 367.9 0.0 1.4 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.1 EWC48126.1 - 4.5e-11 42.5 0.0 1.1e-10 41.2 0.0 1.7 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH Laminin_G_3 PF13385.1 EWC48126.1 - 1.7e-09 38.1 0.0 3.4e-09 37.1 0.0 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily WD40 PF00400.27 EWC48126.1 - 7.4e-08 31.9 7.7 0.0023 17.7 0.2 3.7 4 0 0 4 4 4 2 WD domain, G-beta repeat HET PF06985.6 EWC48128.1 - 1.4e-08 34.9 0.5 7.2e-05 22.9 0.0 2.8 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) Herpes_VP19C PF03327.9 EWC48128.1 - 0.06 12.2 0.0 0.12 11.2 0.0 1.5 1 0 0 1 1 1 0 Herpesvirus capsid shell protein VP19C DUF4341 PF14241.1 EWC48129.1 - 0.2 11.3 1.3 0.55 9.9 0.0 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4341) Sod_Cu PF00080.15 EWC48130.1 - 1.6e-43 148.2 3.5 1.9e-43 148.0 2.4 1.0 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) CNH PF00780.17 EWC48131.1 - 1.9e-72 243.9 0.0 3e-72 243.3 0.0 1.3 1 0 0 1 1 1 1 CNH domain RhoGEF PF00621.15 EWC48131.1 - 5.7e-30 104.5 0.2 8.7e-30 103.9 0.1 1.3 1 0 0 1 1 1 1 RhoGEF domain PH_5 PF15405.1 EWC48131.1 - 1.7e-12 47.4 0.0 6.5e-12 45.5 0.0 2.1 1 1 0 1 1 1 1 Pleckstrin homology domain PH PF00169.24 EWC48131.1 - 1.9e-05 24.8 0.0 5.1e-05 23.4 0.0 1.8 1 0 0 1 1 1 1 PH domain DUF1492 PF07374.6 EWC48131.1 - 4 7.5 5.9 1.8 8.7 1.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1492) YjeF_N PF03853.10 EWC48132.1 - 4.2e-35 120.8 0.0 4.9e-35 120.6 0.0 1.0 1 0 0 1 1 1 1 YjeF-related protein N-terminus DUF429 PF04250.8 EWC48132.1 - 0.075 12.2 0.0 8.8 5.5 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF429) His_Phos_1 PF00300.17 EWC48133.1 - 2.2e-09 37.5 0.0 3.4e-09 36.9 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Inhibitor_I36 PF03995.8 EWC48133.1 - 0.03 14.6 0.0 0.064 13.6 0.0 1.4 1 0 0 1 1 1 0 Peptidase inhibitor family I36 RTC PF01137.16 EWC48134.1 - 7.5e-36 123.0 0.0 1e-35 122.5 0.0 1.2 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase DS PF01916.12 EWC48135.1 - 3.4e-145 482.7 0.0 3.9e-145 482.5 0.0 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase ERCC4 PF02732.10 EWC48136.1 - 2.1e-19 69.6 0.1 2.1e-18 66.4 0.0 2.2 2 0 0 2 2 2 1 ERCC4 domain NARP1 PF12569.3 EWC48136.1 - 9.6 4.8 13.4 10 4.7 6.2 2.2 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 DUF2110 PF09883.4 EWC48137.1 - 0.13 11.8 0.0 0.23 11.0 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2110) Glyco_hydro_17 PF00332.13 EWC48138.1 - 8.8e-08 31.5 1.4 4.3e-07 29.2 0.3 2.0 2 0 0 2 2 2 1 Glycosyl hydrolases family 17 PAT1 PF09770.4 EWC48138.1 - 3.1 5.9 22.8 4.3 5.4 15.8 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 F-box-like PF12937.2 EWC48140.1 - 0.0079 15.9 0.1 0.02 14.6 0.0 1.8 1 0 0 1 1 1 1 F-box-like RNA_pol_Rpb6 PF01192.17 EWC48141.1 - 6.7e-21 73.7 0.1 7.7e-21 73.6 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb6 DUF1932 PF09130.6 EWC48142.1 - 1.5e-17 63.0 0.0 3.4e-17 61.9 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1932) NAD_binding_2 PF03446.10 EWC48142.1 - 0.049 13.4 0.0 0.12 12.2 0.0 1.8 1 1 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Glyco_transf_15 PF01793.11 EWC48144.1 - 3.4e-133 443.6 6.6 4.5e-133 443.2 4.6 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase UDPGP PF01704.13 EWC48144.1 - 0.015 13.7 0.0 0.022 13.2 0.0 1.1 1 0 0 1 1 1 0 UTP--glucose-1-phosphate uridylyltransferase DUF1634 PF07843.6 EWC48144.1 - 0.026 14.1 0.9 0.048 13.3 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1634) Cytochrome-c551 PF10643.4 EWC48144.1 - 0.26 10.5 0.5 0.46 9.7 0.4 1.3 1 0 0 1 1 1 0 Photosystem P840 reaction-centre cytochrome c-551 DUF4604 PF15377.1 EWC48145.1 - 5.1e-23 82.0 18.5 5.8e-23 81.8 12.8 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) Prp19 PF08606.6 EWC48146.1 - 4.6e-34 115.9 0.6 8e-34 115.2 0.4 1.4 1 0 0 1 1 1 1 Prp19/Pso4-like WD40 PF00400.27 EWC48146.1 - 1e-16 60.0 7.2 0.0046 16.7 0.0 6.6 6 0 0 6 6 6 4 WD domain, G-beta repeat Coatomer_WDAD PF04053.9 EWC48146.1 - 0.00012 21.0 0.0 0.019 13.7 0.0 2.1 1 1 1 2 2 2 2 Coatomer WD associated region Gmad1 PF10647.4 EWC48146.1 - 0.00072 19.0 5.4 0.0044 16.4 3.7 2.1 1 1 0 1 1 1 1 Lipoprotein LpqB beta-propeller domain zf-Nse PF11789.3 EWC48146.1 - 0.00089 18.7 0.0 0.0016 17.8 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit eIF2A PF08662.6 EWC48146.1 - 0.0009 19.0 0.0 0.04 13.6 0.0 2.2 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.11 EWC48146.1 - 0.0027 16.0 0.0 0.0053 15.0 0.0 1.4 1 1 0 1 1 1 1 Cytochrome D1 heme domain zf-RING_5 PF14634.1 EWC48147.1 - 0.00024 20.7 6.6 0.00041 20.0 4.6 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 EWC48147.1 - 0.0019 18.1 5.7 0.0037 17.2 4.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EWC48147.1 - 0.0036 17.0 4.9 0.0073 16.1 3.4 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.1 EWC48147.1 - 0.005 16.4 5.5 0.0099 15.5 3.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EWC48147.1 - 0.2 11.3 4.5 0.4 10.3 3.1 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) PTPLA PF04387.9 EWC48148.1 - 7.5e-51 171.8 3.2 1.4e-50 170.8 2.2 1.5 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA Adaptin_binding PF10199.4 EWC48149.1 - 5.1e-18 65.6 8.6 5.9e-18 65.4 4.8 1.9 2 0 0 2 2 2 1 Alpha and gamma adaptin binding protein p34 Tom22 PF04281.8 EWC48149.1 - 0.022 14.2 1.2 0.048 13.2 0.8 1.5 1 0 0 1 1 1 0 Mitochondrial import receptor subunit Tom22 LSM PF01423.17 EWC48150.1 - 5.5e-14 51.4 0.3 7.5e-14 51.0 0.2 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.1 EWC48150.1 - 0.025 14.5 0.1 0.047 13.6 0.1 1.5 1 1 0 1 1 1 0 Ataxin 2 SM domain DUF2392 PF10288.4 EWC48151.1 - 4e-16 59.2 0.0 6.5e-16 58.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2392) ATP_bind_3 PF01171.15 EWC48151.1 - 5.7e-05 22.6 0.1 0.048 13.1 0.0 2.5 2 1 1 3 3 3 2 PP-loop family DZR PF12773.2 EWC48151.1 - 0.73 9.6 9.0 0.73 9.7 0.7 3.0 2 1 0 2 2 2 0 Double zinc ribbon CorA PF01544.13 EWC48152.1 - 2.7e-32 111.9 6.4 2.6e-29 102.1 2.4 2.7 1 1 1 2 2 2 2 CorA-like Mg2+ transporter protein Cation_efflux PF01545.16 EWC48155.1 - 5.1e-31 107.8 8.8 6.5e-31 107.4 6.1 1.1 1 0 0 1 1 1 1 Cation efflux family EF-hand_7 PF13499.1 EWC48156.1 - 0.0012 18.9 0.8 0.99 9.5 0.0 2.6 2 1 0 2 2 2 2 EF-hand domain pair DUF3414 PF11894.3 EWC48157.1 - 0 1139.5 12.9 0 1139.3 9.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3414) PI3_PI4_kinase PF00454.22 EWC48158.1 - 4.5e-44 150.6 0.0 1.8e-43 148.7 0.0 2.1 2 0 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase TAN PF11640.3 EWC48158.1 - 4.2e-31 107.7 2.2 2.4e-30 105.3 1.5 2.5 1 0 0 1 1 1 1 Telomere-length maintenance and DNA damage repair FATC PF02260.15 EWC48158.1 - 1.8e-10 40.0 0.0 6e-10 38.3 0.0 2.0 1 0 0 1 1 1 1 FATC domain HEAT PF02985.17 EWC48158.1 - 0.027 14.5 1.1 9.5 6.6 0.0 4.5 3 0 0 3 3 3 0 HEAT repeat DNA_pol_A PF00476.15 EWC48159.1 - 2.7e-100 335.7 0.1 2.7e-100 335.7 0.1 2.2 2 0 0 2 2 2 1 DNA polymerase family A DNA_pol_A_exo1 PF01612.15 EWC48159.1 - 0.0022 17.5 2.4 0.0022 17.5 1.7 2.8 2 1 0 2 2 2 1 3'-5' exonuclease DNA_pol_B_2 PF03175.8 EWC48159.1 - 0.59 8.7 4.4 0.065 11.8 0.1 1.5 2 0 0 2 2 2 0 DNA polymerase type B, organellar and viral zf-C3HC4_3 PF13920.1 EWC48160.1 - 8.7e-12 44.5 4.9 1.3e-11 43.9 3.4 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 EWC48160.1 - 1.7e-10 40.7 8.5 2.6e-10 40.1 5.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EWC48160.1 - 2.3e-10 40.1 7.2 3.5e-10 39.5 5.0 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 EWC48160.1 - 5.2e-09 35.6 7.9 8e-09 35.0 5.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EWC48160.1 - 1.1e-07 31.4 7.5 1.8e-07 30.7 5.2 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.1 EWC48160.1 - 0.0042 16.7 6.0 0.0044 16.6 3.2 1.9 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.1 EWC48160.1 - 0.0084 15.9 7.6 0.017 15.0 5.2 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.1 EWC48160.1 - 0.02 14.4 5.6 0.051 13.1 3.9 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-Apc11 PF12861.2 EWC48160.1 - 0.029 14.2 0.9 0.048 13.4 0.6 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger MtrA PF04208.9 EWC48160.1 - 0.041 13.3 0.1 0.061 12.7 0.1 1.2 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit A Daxx PF03344.10 EWC48160.1 - 0.045 12.2 9.2 0.053 12.0 6.4 1.1 1 0 0 1 1 1 0 Daxx Family zf-RING_6 PF14835.1 EWC48160.1 - 0.082 12.7 3.7 0.22 11.3 2.6 1.6 1 1 0 1 1 1 0 zf-RING of BARD1-type protein TFIIF_alpha PF05793.7 EWC48160.1 - 0.21 9.8 8.9 0.29 9.4 6.2 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Nop14 PF04147.7 EWC48160.1 - 0.28 9.0 12.5 0.32 8.8 8.7 1.1 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.7 EWC48160.1 - 0.31 10.2 14.6 0.43 9.8 10.1 1.1 1 0 0 1 1 1 0 SDA1 Prok-RING_4 PF14447.1 EWC48160.1 - 0.32 10.5 6.6 2.2 7.8 4.6 2.1 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 zf-rbx1 PF12678.2 EWC48160.1 - 0.55 10.3 5.2 1.2 9.2 3.6 1.6 1 1 0 1 1 1 0 RING-H2 zinc finger Rtf2 PF04641.7 EWC48160.1 - 1.1 8.3 6.1 0.13 11.4 0.4 1.9 1 1 0 2 2 2 0 Rtf2 RING-finger Prim_Zn_Ribbon PF08273.7 EWC48160.1 - 2 8.5 5.9 16 5.7 0.9 2.4 2 0 0 2 2 2 0 Zinc-binding domain of primase-helicase Nucleoplasmin PF03066.10 EWC48160.1 - 3.1 7.3 12.5 0.21 11.1 5.0 1.7 2 0 0 2 2 2 0 Nucleoplasmin DUF1644 PF07800.7 EWC48160.1 - 6.7 6.5 6.8 2.9 7.7 0.3 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1644) LDB19 PF13002.2 EWC48161.1 - 8e-49 165.7 0.1 2e-48 164.4 0.0 1.6 2 0 0 2 2 2 1 Arrestin_N terminal like Arrestin_N PF00339.24 EWC48161.1 - 8.4e-07 28.9 0.1 6.4e-06 26.0 0.0 2.4 3 0 0 3 3 3 1 Arrestin (or S-antigen), N-terminal domain Amidohydro_2 PF04909.9 EWC48162.1 - 7.6e-22 78.1 0.9 1.4e-21 77.2 0.7 1.4 1 1 0 1 1 1 1 Amidohydrolase DIOX_N PF14226.1 EWC48163.1 - 1.9e-20 73.5 0.0 3.3e-20 72.7 0.0 1.4 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.15 EWC48163.1 - 2.2e-13 50.3 0.0 3.4e-13 49.7 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily EXOSC1 PF10447.4 EWC48167.1 - 7.4e-26 89.9 3.2 1.2e-25 89.2 2.2 1.4 1 0 0 1 1 1 1 Exosome component EXOSC1/CSL4 ECR1_N PF14382.1 EWC48167.1 - 9.9e-11 40.7 1.9 1.4e-10 40.2 0.5 2.0 2 0 0 2 2 2 1 Exosome complex exonuclease RRP4 N-terminal region CRAL_TRIO PF00650.15 EWC48168.1 - 3.9e-35 120.6 0.0 5.4e-35 120.2 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.10 EWC48168.1 - 3.9e-11 42.9 0.2 8.3e-11 41.8 0.1 1.6 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.1 EWC48168.1 - 7.3e-06 25.9 0.0 1.2e-05 25.2 0.0 1.2 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Pol_alpha_B_N PF08418.5 EWC48169.1 - 2e-48 165.1 0.1 3.1e-48 164.5 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase alpha subunit B N-terminal DNA_pol_E_B PF04042.11 EWC48169.1 - 2.5e-27 95.4 0.3 4e-27 94.8 0.2 1.3 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B UreD PF01774.12 EWC48170.1 - 7.5e-45 152.9 0.7 3e-44 151.0 0.5 1.8 1 1 0 1 1 1 1 UreD urease accessory protein GATase_4 PF13230.1 EWC48171.1 - 3.3e-17 62.0 0.0 6.3e-16 57.8 0.0 2.0 2 0 0 2 2 2 1 Glutamine amidotransferases class-II GATase_6 PF13522.1 EWC48171.1 - 1.2e-09 38.2 0.0 2e-09 37.5 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_2 PF00310.16 EWC48171.1 - 6.5e-09 34.9 0.0 6.7e-07 28.3 0.0 2.2 2 0 0 2 2 2 2 Glutamine amidotransferases class-II Dynamin_N PF00350.18 EWC48172.1 - 5.5e-43 146.6 0.0 1.2e-42 145.5 0.0 1.6 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.15 EWC48172.1 - 8.3e-13 47.7 0.6 1.1e-10 40.8 0.0 2.3 2 0 0 2 2 2 2 Dynamin central region MMR_HSR1 PF01926.18 EWC48172.1 - 0.0012 18.7 0.0 0.0032 17.4 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 EWC48172.1 - 0.0037 17.7 0.0 0.0093 16.4 0.0 1.7 1 0 0 1 1 1 1 Miro-like protein AAA_21 PF13304.1 EWC48172.1 - 0.07 13.0 0.4 0.17 11.7 0.0 1.8 2 0 0 2 2 2 0 AAA domain DUF2939 PF11159.3 EWC48172.1 - 0.1 12.7 0.6 0.39 10.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2939) DXP_redisom_C PF08436.7 EWC48172.1 - 0.16 11.8 0.0 0.57 10.1 0.0 1.9 1 0 0 1 1 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal FAD_binding_7 PF03441.9 EWC48173.1 - 1.3e-94 316.4 0.1 1.9e-94 315.9 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.13 EWC48173.1 - 2.1e-42 144.6 0.0 3.5e-42 143.9 0.0 1.3 1 0 0 1 1 1 1 DNA photolyase PH PF00169.24 EWC48174.1 - 1.8e-30 105.2 3.9 2.1e-16 59.9 0.1 2.1 2 0 0 2 2 2 2 PH domain PH_11 PF15413.1 EWC48174.1 - 1.1e-11 44.9 6.4 1.8e-05 24.9 0.3 3.4 2 2 0 2 2 2 2 Pleckstrin homology domain PH_9 PF15410.1 EWC48174.1 - 6.1e-09 36.0 3.1 0.00055 20.0 0.1 3.9 2 2 0 2 2 2 2 Pleckstrin homology domain PH_8 PF15409.1 EWC48174.1 - 1.5e-06 28.2 1.6 1.7e-05 24.7 0.1 2.4 2 0 0 2 2 2 1 Pleckstrin homology domain BCL_N PF04714.8 EWC48174.1 - 1.8 8.1 8.2 0.99 9.0 0.7 2.4 2 0 0 2 2 2 0 BCL7, N-terminal conserver region CENP-B_dimeris PF09026.5 EWC48176.1 - 0.0018 18.4 4.1 0.066 13.4 2.3 2.2 2 0 0 2 2 2 1 Centromere protein B dimerisation domain Bd3614_N PF14442.1 EWC48176.1 - 0.068 13.1 0.4 0.12 12.4 0.3 1.5 1 0 0 1 1 1 0 Bd3614-like deaminase N-terminal Nucleoplasmin PF03066.10 EWC48176.1 - 0.087 12.3 2.2 0.15 11.5 1.5 1.3 1 0 0 1 1 1 0 Nucleoplasmin PIG-Y PF15159.1 EWC48176.1 - 0.15 12.2 7.7 0.26 11.5 2.1 2.2 2 0 0 2 2 2 0 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y DUF1218 PF06749.7 EWC48176.1 - 1.2 9.6 6.7 0.63 10.5 0.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1218) Cullin_binding PF03556.10 EWC48177.1 - 6e-34 116.6 2.2 7.7e-34 116.3 1.5 1.1 1 0 0 1 1 1 1 Cullin binding SH3_1 PF00018.23 EWC48178.1 - 1.2e-05 24.5 0.0 2.6e-05 23.5 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 EWC48178.1 - 0.0054 16.2 0.0 0.011 15.3 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain PY_rept_46 PF09689.5 EWC48178.1 - 0.024 14.9 7.4 0.099 12.9 5.1 2.2 1 0 0 1 1 1 0 Plasmodium yoelii repeat (PY_rept_46) Pkinase PF00069.20 EWC48179.1 - 6.3e-48 163.1 0.0 1.4e-47 162.0 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC48179.1 - 5.2e-28 97.8 0.0 4.2e-21 75.2 0.0 2.4 3 0 0 3 3 3 2 Protein tyrosine kinase Kinase-like PF14531.1 EWC48179.1 - 0.012 14.5 0.0 0.021 13.7 0.0 1.4 1 0 0 1 1 1 0 Kinase-like APH PF01636.18 EWC48179.1 - 0.069 12.8 0.0 0.15 11.7 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Mpv17_PMP22 PF04117.7 EWC48180.1 - 2.9e-12 46.0 2.1 1.6e-11 43.6 0.4 2.2 1 1 0 2 2 2 1 Mpv17 / PMP22 family QueT PF06177.6 EWC48180.1 - 0.093 12.7 3.5 0.14 12.1 0.9 2.0 1 1 0 2 2 2 0 QueT transporter GTP_EFTU PF00009.22 EWC48181.1 - 2.6e-51 173.7 0.0 6.5e-51 172.4 0.0 1.7 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain EFG_C PF00679.19 EWC48181.1 - 3.6e-16 58.8 0.1 2.8e-15 55.9 0.0 2.3 2 0 0 2 2 2 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.20 EWC48181.1 - 1.8e-09 37.5 0.0 5.2e-09 36.1 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.1 EWC48181.1 - 1.2e-06 28.3 0.0 3.4e-06 26.7 0.0 1.9 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_IV PF03764.13 EWC48181.1 - 6.7e-06 25.6 0.1 8e-05 22.1 0.0 2.8 1 1 2 3 3 3 1 Elongation factor G, domain IV Mhr1 PF12829.2 EWC48182.1 - 4e-26 90.6 0.1 7.8e-26 89.7 0.0 1.4 1 0 0 1 1 1 1 Transcriptional regulation of mitochondrial recombination PEX11 PF05648.9 EWC48183.1 - 9.5e-11 41.3 3.7 2.3e-06 27.0 3.9 2.7 2 1 0 2 2 2 2 Peroxisomal biogenesis factor 11 (PEX11) Snf7 PF03357.16 EWC48184.1 - 1e-30 106.3 22.9 1e-30 106.3 15.9 2.9 2 1 1 3 3 3 2 Snf7 Atg14 PF10186.4 EWC48184.1 - 3.7e-16 58.9 0.1 3.7e-16 58.9 0.1 2.7 2 1 0 2 2 2 1 UV radiation resistance protein and autophagy-related subunit 14 YlqD PF11068.3 EWC48184.1 - 1.5 8.8 25.2 13 5.8 4.0 3.3 2 1 1 3 3 3 0 YlqD protein Dynamin_N PF00350.18 EWC48185.1 - 1.4e-17 64.0 0.0 2.8e-17 63.0 0.0 1.5 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.18 EWC48185.1 - 2.2e-09 37.2 0.0 8.9e-09 35.3 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 EWC48185.1 - 1.4e-06 27.9 0.3 2.8e-05 23.6 0.2 2.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_17 PF13207.1 EWC48185.1 - 0.0097 16.7 0.1 0.21 12.4 0.0 3.1 2 1 1 3 3 3 1 AAA domain DUF2205 PF10224.4 EWC48185.1 - 0.018 14.6 2.3 0.018 14.6 0.1 2.1 2 0 0 2 2 2 0 Predicted coiled-coil protein (DUF2205) Miro PF08477.8 EWC48185.1 - 0.024 15.1 0.1 0.54 10.7 0.0 2.9 1 1 0 1 1 1 0 Miro-like protein DUF445 PF04286.7 EWC48185.1 - 0.041 13.4 2.0 2.4 7.5 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF445) HDOD PF08668.7 EWC48185.1 - 0.058 12.6 0.3 0.14 11.3 0.2 1.6 1 0 0 1 1 1 0 HDOD domain AAA_29 PF13555.1 EWC48185.1 - 0.077 12.5 0.0 0.18 11.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain PduV-EutP PF10662.4 EWC48185.1 - 0.14 11.6 0.0 18 4.7 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation IF3_C PF00707.17 EWC48186.1 - 4.1e-13 48.8 0.1 6.4e-13 48.2 0.0 1.3 1 0 0 1 1 1 1 Translation initiation factor IF-3, C-terminal domain mIF3 PF14877.1 EWC48186.1 - 8.1e-05 22.0 0.8 0.00012 21.4 0.5 1.2 1 0 0 1 1 1 1 Mitochondrial translation initiation factor Calc_CGRP_IAPP PF00214.14 EWC48186.1 - 0.12 12.4 0.1 0.26 11.3 0.1 1.6 1 1 0 1 1 1 0 Calcitonin / CGRP / IAPP family LSM PF01423.17 EWC48187.1 - 5.2e-18 64.3 0.1 7.1e-18 63.9 0.1 1.2 1 0 0 1 1 1 1 LSM domain GATA PF00320.22 EWC48188.1 - 1.5e-06 27.4 2.2 6.5e-06 25.3 1.5 2.0 1 1 0 1 1 1 1 GATA zinc finger AT_hook PF02178.14 EWC48188.1 - 0.28 10.9 13.8 1.9 8.4 2.8 3.1 2 0 0 2 2 2 0 AT hook motif Rep_fac-A_3 PF08661.6 EWC48189.1 - 1.8e-23 82.4 0.7 2.1e-23 82.2 0.5 1.0 1 0 0 1 1 1 1 Replication factor A protein 3 Ribosomal_L35Ae PF01247.13 EWC48189.1 - 0.14 11.9 0.2 4.8 7.0 0.1 2.1 1 1 1 2 2 2 0 Ribosomal protein L35Ae Peptidase_S24 PF00717.18 EWC48190.1 - 6.3e-08 32.1 0.5 1.2e-07 31.2 0.3 1.4 1 0 0 1 1 1 1 Peptidase S24-like Peptidase_S26 PF10502.4 EWC48190.1 - 3.5e-07 29.8 0.0 0.00039 19.9 0.0 2.4 1 1 1 2 2 2 2 Signal peptidase, peptidase S26 PBP PF01161.15 EWC48191.1 - 1.7e-12 47.4 0.1 2.9e-12 46.6 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein Ribosomal_L4 PF00573.17 EWC48192.1 - 8.5e-50 168.8 0.0 1.4e-49 168.1 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family ECH_C PF13766.1 EWC48193.1 - 8e-29 100.1 0.0 2.8e-28 98.4 0.0 1.9 2 0 0 2 2 2 1 2-enoyl-CoA Hydratase C-terminal region ECH PF00378.15 EWC48193.1 - 1.8e-26 92.7 0.0 2.9e-26 92.0 0.0 1.4 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family bZIP_1 PF00170.16 EWC48194.1 - 3.2e-08 33.4 11.3 3.2e-08 33.4 7.8 2.3 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.10 EWC48194.1 - 2.3e-05 24.1 12.7 2.3e-05 24.0 6.6 2.4 2 0 0 2 2 2 1 Basic region leucine zipper PE_PPE_C PF12484.3 EWC48194.1 - 0.43 11.5 5.7 0.13 13.2 1.1 2.4 2 0 0 2 2 2 0 Polymorphic PE/PPE proteins C terminal bZIP_Maf PF03131.12 EWC48194.1 - 7.4 6.9 14.0 0.32 11.3 4.4 2.6 2 1 1 3 3 3 0 bZIP Maf transcription factor GTP_EFTU PF00009.22 EWC48195.1 - 7.3e-60 201.6 0.1 9.9e-60 201.1 0.1 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 EWC48195.1 - 3.6e-26 91.2 0.0 1.8e-25 89.0 0.0 2.1 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 EWC48195.1 - 6.7e-18 64.5 2.8 1.7e-17 63.2 1.9 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 EWC48195.1 - 3.2e-05 23.8 0.0 5.9e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 EWC48195.1 - 0.00077 19.9 0.0 0.0013 19.2 0.0 1.4 1 0 0 1 1 1 1 Miro-like protein GTP_EFTU_D4 PF14578.1 EWC48195.1 - 0.0026 17.3 0.4 0.0088 15.6 0.3 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 4 PduV-EutP PF10662.4 EWC48195.1 - 0.026 14.0 0.2 6.1 6.3 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation GTP_EFTU PF00009.22 EWC48196.1 - 3.4e-23 82.0 0.1 5.7e-23 81.3 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 EWC48196.1 - 1.2e-15 57.4 0.0 3.7e-15 55.8 0.0 1.9 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 EWC48196.1 - 5e-09 36.1 1.4 5e-08 32.9 1.1 2.5 2 0 0 2 2 2 1 Elongation factor Tu domain 2 PduV-EutP PF10662.4 EWC48196.1 - 0.0012 18.2 1.2 0.4 10.1 0.2 3.3 2 1 1 3 3 3 1 Ethanolamine utilisation - propanediol utilisation Miro PF08477.8 EWC48196.1 - 0.0018 18.7 0.0 0.0065 16.9 0.0 2.0 1 1 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 EWC48196.1 - 0.0097 15.8 0.1 0.029 14.3 0.1 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.1 EWC48196.1 - 0.047 13.3 0.2 0.23 11.1 0.1 2.2 1 0 0 1 1 1 0 Elongation factor Tu domain 4 Ribonuc_red_sm PF00268.16 EWC48197.1 - 3.2e-118 393.8 1.5 3.9e-118 393.5 1.1 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain DUF1308 PF07000.6 EWC48198.1 - 7.1e-56 189.3 0.0 9.3e-56 189.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1308) Lung_7-TM_R PF06814.8 EWC48199.1 - 5.7e-71 238.8 17.4 7e-71 238.5 12.0 1.1 1 0 0 1 1 1 1 Lung seven transmembrane receptor PGP_phosphatase PF09419.5 EWC48200.1 - 2.5e-64 215.6 0.0 2.9e-64 215.4 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial PGP phosphatase Hydrolase_like PF13242.1 EWC48200.1 - 8.8e-05 22.1 0.0 0.00015 21.3 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like HAD_2 PF13419.1 EWC48200.1 - 0.052 13.7 0.1 0.19 11.9 0.1 1.8 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Homeobox PF00046.24 EWC48201.1 - 5.1e-19 67.6 3.7 1.3e-18 66.3 2.6 1.8 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.6 EWC48201.1 - 0.00084 18.9 0.3 0.0022 17.6 0.2 1.7 1 0 0 1 1 1 1 Homeobox KN domain Flu_B_NS1 PF02942.9 EWC48201.1 - 0.072 11.9 0.0 0.14 11.0 0.0 1.4 1 0 0 1 1 1 0 Influenza B non-structural protein (NS1) E1-E2_ATPase PF00122.15 EWC48202.1 - 3.3e-16 59.0 1.3 5.5e-16 58.2 0.0 1.9 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.21 EWC48202.1 - 3e-15 57.2 0.7 1.8e-11 44.8 0.2 2.8 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.2 EWC48202.1 - 9.3e-13 48.7 0.3 7.1e-12 45.8 0.2 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 EWC48202.1 - 3e-09 36.6 0.0 8.7e-09 35.2 0.0 1.8 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 EWC48202.1 - 0.00036 20.2 0.0 0.0013 18.3 0.0 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 EWC48202.1 - 0.03 14.5 0.1 0.091 12.9 0.0 1.8 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Sec62 PF03839.11 EWC48202.1 - 0.72 9.2 7.3 0.095 12.1 1.8 1.9 2 0 0 2 2 2 0 Translocation protein Sec62 zf-MYND PF01753.13 EWC48203.1 - 1.7e-07 31.0 19.8 2.8e-07 30.2 13.7 1.4 1 0 0 1 1 1 1 MYND finger WD40 PF00400.27 EWC48204.1 - 2.4e-17 62.0 0.3 1.3e-08 34.3 0.0 5.0 5 0 0 5 5 5 4 WD domain, G-beta repeat Mito_carr PF00153.22 EWC48205.1 - 1.9e-56 187.7 5.6 4.8e-19 67.8 0.2 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Tim17 PF02466.14 EWC48205.1 - 0.59 10.1 5.4 4.2 7.4 1.9 3.0 2 1 0 2 2 2 0 Tim17/Tim22/Tim23/Pmp24 family DIOX_N PF14226.1 EWC48206.1 - 7.3e-19 68.4 0.1 1.1e-18 67.8 0.0 1.2 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.15 EWC48206.1 - 2.7e-16 59.6 0.0 4.7e-16 58.8 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily MKT1_C PF12246.3 EWC48207.1 - 5.4e-60 202.4 0.0 1.3e-59 201.1 0.0 1.6 2 0 0 2 2 2 1 Temperature dependent protein affecting M2 dsRNA replication MKT1_N PF12247.3 EWC48207.1 - 1e-27 96.2 0.1 4.9e-27 94.0 0.0 2.3 2 0 0 2 2 2 1 Temperature dependent protein affecting M2 dsRNA replication XPG_I PF00867.13 EWC48207.1 - 6.5e-10 38.9 0.0 1.4e-09 37.8 0.0 1.6 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.12 EWC48207.1 - 0.015 15.5 0.0 0.044 14.0 0.0 1.7 1 0 0 1 1 1 0 XPG N-terminal domain WD40 PF00400.27 EWC48208.1 - 3.9e-35 118.4 8.5 6.8e-09 35.2 0.0 8.8 8 1 0 8 8 8 6 WD domain, G-beta repeat BBS2_Mid PF14783.1 EWC48208.1 - 0.07 12.9 0.1 9.5 6.0 0.0 3.8 3 2 1 4 4 4 0 Ciliary BBSome complex subunit 2, middle region Cytochrom_D1 PF02239.11 EWC48208.1 - 0.088 11.0 0.0 0.31 9.2 0.0 1.9 2 0 0 2 2 2 0 Cytochrome D1 heme domain Mating_C PF12737.2 EWC48209.1 - 0.0097 14.8 2.9 0.014 14.2 2.0 1.4 1 0 0 1 1 1 1 C-terminal domain of homeodomain 1 OHCU_decarbox PF09349.5 EWC48210.1 - 6.5e-23 81.7 0.1 7.4e-23 81.5 0.1 1.0 1 0 0 1 1 1 1 OHCU decarboxylase VEK-30 PF12107.3 EWC48210.1 - 0.29 10.8 4.4 0.67 9.7 3.0 1.6 1 0 0 1 1 1 0 Plasminogen (Pg) ligand in fibrinolytic pathway S1 PF00575.18 EWC48211.1 - 8.3e-87 285.3 37.5 1.8e-14 53.6 0.0 12.5 12 0 0 12 12 12 12 S1 RNA binding domain TPR_19 PF14559.1 EWC48211.1 - 4e-06 27.0 5.9 0.00023 21.4 0.2 3.4 2 1 0 3 3 3 1 Tetratricopeptide repeat Suf PF05843.9 EWC48211.1 - 4e-06 26.7 8.0 9.5e-05 22.2 0.2 2.9 2 1 1 3 3 3 2 Suppressor of forked protein (Suf) TPR_14 PF13428.1 EWC48211.1 - 2.2e-05 24.6 10.4 0.021 15.4 0.3 5.0 2 2 3 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.1 EWC48211.1 - 2.4e-05 24.8 13.5 0.0061 17.2 4.1 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat S1_2 PF13509.1 EWC48211.1 - 0.037 13.9 0.2 7 6.6 0.0 4.3 6 0 0 6 6 6 0 S1 domain TPR_12 PF13424.1 EWC48211.1 - 0.048 13.5 2.6 0.23 11.3 0.8 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat NRDE-2 PF08424.5 EWC48211.1 - 0.056 12.3 0.5 0.39 9.5 0.2 2.4 2 1 1 3 3 3 0 NRDE-2, necessary for RNA interference TPR_6 PF13174.1 EWC48211.1 - 1 9.9 6.9 0.49 10.9 0.3 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Ras PF00071.17 EWC48212.1 - 6.9e-57 191.3 0.1 8.5e-57 191.0 0.1 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EWC48212.1 - 5.3e-20 72.1 0.0 7.6e-20 71.5 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EWC48212.1 - 5e-14 51.9 0.0 6.2e-14 51.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 EWC48212.1 - 2.3e-07 30.7 0.0 3.5e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 EWC48212.1 - 6.4e-07 28.9 0.0 1.9e-05 24.2 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 EWC48212.1 - 1.7e-06 27.3 0.0 2e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_22 PF13401.1 EWC48212.1 - 0.0004 20.5 0.0 0.0008 19.5 0.0 1.7 1 1 0 1 1 1 1 AAA domain DUF258 PF03193.11 EWC48212.1 - 0.00063 18.9 0.2 0.0013 17.8 0.1 1.6 1 1 0 1 1 1 1 Protein of unknown function, DUF258 AAA_24 PF13479.1 EWC48212.1 - 0.0019 17.7 0.1 0.0033 17.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain PduV-EutP PF10662.4 EWC48212.1 - 0.003 17.0 0.0 0.099 12.1 0.0 2.2 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation ATP_bind_1 PF03029.12 EWC48212.1 - 0.003 17.1 0.4 0.092 12.2 0.0 2.1 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein Septin PF00735.13 EWC48212.1 - 0.0034 16.4 0.0 0.023 13.7 0.0 2.1 2 0 0 2 2 2 1 Septin Arch_ATPase PF01637.13 EWC48212.1 - 0.0043 16.7 0.0 0.0077 15.9 0.0 1.3 1 0 0 1 1 1 1 Archaeal ATPase AAA_16 PF13191.1 EWC48212.1 - 0.0086 16.0 0.1 0.025 14.5 0.0 1.9 2 1 0 2 2 2 1 AAA ATPase domain SRPRB PF09439.5 EWC48212.1 - 0.0089 15.2 0.0 0.011 14.9 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_10 PF12846.2 EWC48212.1 - 0.0091 15.4 0.2 0.019 14.3 0.1 1.4 1 1 0 1 1 1 1 AAA-like domain AAA_5 PF07728.9 EWC48212.1 - 0.0094 15.6 0.0 0.016 14.9 0.0 1.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) NTPase_1 PF03266.10 EWC48212.1 - 0.0097 15.6 0.0 0.016 14.9 0.0 1.4 1 0 0 1 1 1 1 NTPase cobW PF02492.14 EWC48212.1 - 0.012 15.1 0.0 0.034 13.5 0.0 1.7 1 1 1 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain MobB PF03205.9 EWC48212.1 - 0.029 14.0 0.1 0.058 13.0 0.1 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Sigma54_activat PF00158.21 EWC48212.1 - 0.031 13.7 0.0 0.043 13.2 0.0 1.2 1 0 0 1 1 1 0 Sigma-54 interaction domain DAP3 PF10236.4 EWC48212.1 - 0.059 12.2 0.6 0.098 11.5 0.2 1.4 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 NACHT PF05729.7 EWC48212.1 - 0.09 12.4 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 NACHT domain ATG16 PF08614.6 EWC48213.1 - 6.1e-37 127.3 12.6 8.2e-37 126.9 8.7 1.2 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Dynamitin PF04912.9 EWC48213.1 - 0.0003 19.7 2.1 0.0003 19.7 1.5 1.5 2 0 0 2 2 2 1 Dynamitin MTBP_C PF14920.1 EWC48213.1 - 0.016 14.7 3.3 0.019 14.4 2.3 1.1 1 0 0 1 1 1 0 MDM2-binding DUF4201 PF13870.1 EWC48213.1 - 0.019 14.4 12.8 0.032 13.6 8.6 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4201) zf-C4H2 PF10146.4 EWC48213.1 - 0.067 13.2 14.1 0.15 12.0 4.1 2.1 1 1 1 2 2 2 0 Zinc finger-containing protein ADIP PF11559.3 EWC48213.1 - 0.068 13.0 17.6 0.22 11.3 8.8 2.2 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding GvpG PF05120.7 EWC48213.1 - 0.088 12.6 8.6 0.034 13.9 1.9 2.7 2 1 0 2 2 2 0 Gas vesicle protein G IncA PF04156.9 EWC48213.1 - 0.094 12.2 12.1 0.24 10.9 8.2 1.8 1 1 1 2 2 2 0 IncA protein DUF1180 PF06679.7 EWC48213.1 - 0.78 9.6 6.4 1.2 9.0 4.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) APG6 PF04111.7 EWC48213.1 - 1.6 7.7 13.3 0.36 9.8 5.3 1.9 1 1 1 2 2 2 0 Autophagy protein Apg6 CDC37_N PF03234.9 EWC48213.1 - 2.8 8.2 10.2 3.9 7.7 7.1 1.2 1 0 0 1 1 1 0 Cdc37 N terminal kinase binding DOT1 PF08123.8 EWC48214.1 - 5.4e-63 212.0 0.0 7.5e-63 211.5 0.0 1.2 1 0 0 1 1 1 1 Histone methylation protein DOT1 CMAS PF02353.15 EWC48214.1 - 0.0017 17.5 0.0 0.0031 16.6 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_26 PF13659.1 EWC48214.1 - 0.0019 18.2 0.0 0.0041 17.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EWC48214.1 - 0.015 15.8 0.0 0.034 14.7 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.1 EWC48214.1 - 0.1 12.2 0.0 0.29 10.6 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain DUF4591 PF15261.1 EWC48214.1 - 7.3 6.8 8.9 3.9 7.7 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4591) Cwf_Cwc_15 PF04889.7 EWC48215.1 - 0.00012 21.8 21.5 0.034 13.8 0.8 2.6 2 0 0 2 2 2 2 Cwf15/Cwc15 cell cycle control protein CTDII PF01556.13 EWC48216.1 - 4.1e-19 68.2 0.1 6.8e-16 57.9 0.0 3.2 3 0 0 3 3 3 2 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.14 EWC48216.1 - 9.5e-12 44.8 19.1 9.5e-12 44.8 13.2 1.7 2 0 0 2 2 2 1 DnaJ central domain DnaJ PF00226.26 EWC48216.1 - 4.4e-10 39.1 1.7 7.9e-10 38.3 1.2 1.4 1 0 0 1 1 1 1 DnaJ domain DUF1356 PF07092.7 EWC48216.1 - 0.34 10.0 4.8 2.8 7.0 0.1 2.4 1 1 2 3 3 3 0 Protein of unknown function (DUF1356) HypA PF01155.14 EWC48216.1 - 0.76 9.4 8.2 3.5 7.3 1.7 2.6 2 0 0 2 2 2 0 Hydrogenase expression/synthesis hypA family tRNA-synt_1c PF00749.16 EWC48217.1 - 1e-76 257.6 0.0 5.8e-71 238.7 0.0 2.1 2 0 0 2 2 2 2 tRNA synthetases class I (E and Q), catalytic domain WD40 PF00400.27 EWC48218.1 - 2.6e-24 84.1 16.3 2e-07 30.6 0.0 6.8 7 0 0 7 7 7 6 WD domain, G-beta repeat Nup160 PF11715.3 EWC48218.1 - 0.00026 19.2 0.0 0.00056 18.1 0.0 1.5 2 0 0 2 2 2 1 Nucleoporin Nup120/160 DUF2415 PF10313.4 EWC48218.1 - 0.0092 15.6 0.0 0.017 14.7 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised protein domain (DUF2415) PQQ_3 PF13570.1 EWC48218.1 - 0.021 15.0 1.5 2.9 8.2 0.0 4.1 4 0 0 4 4 4 0 PQQ-like domain Spb1_C PF07780.7 EWC48219.1 - 1.1e-67 227.6 35.9 1.1e-67 227.6 24.9 5.1 3 2 0 4 4 4 1 Spb1 C-terminal domain FtsJ PF01728.14 EWC48219.1 - 5.8e-54 182.8 0.1 1.7e-53 181.2 0.0 1.9 2 0 0 2 2 2 1 FtsJ-like methyltransferase DUF3381 PF11861.3 EWC48219.1 - 3.7e-50 169.5 17.8 3.7e-50 169.5 12.4 4.7 3 1 2 5 5 5 1 Domain of unknown function (DUF3381) JAB PF01398.16 EWC48220.1 - 3.5e-30 104.0 0.0 1.2e-29 102.3 0.0 1.8 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.1 EWC48220.1 - 1e-07 31.4 0.0 9.4e-07 28.3 0.0 2.2 2 0 0 2 2 2 1 Prokaryotic homologs of the JAB domain UPF0172 PF03665.8 EWC48220.1 - 0.001 18.6 0.0 0.0025 17.3 0.0 1.7 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0172) MAP65_ASE1 PF03999.7 EWC48221.1 - 1e-69 235.8 17.2 1.7e-69 235.0 11.9 1.4 1 0 0 1 1 1 1 Microtubule associated protein (MAP65/ASE1 family) Ded_cyto PF06920.8 EWC48221.1 - 0.0097 15.2 4.0 0.025 13.8 0.1 2.6 3 0 0 3 3 3 1 Dedicator of cytokinesis Baculo_p24 PF05073.7 EWC48221.1 - 0.011 15.3 8.5 0.23 11.0 0.2 3.4 3 0 0 3 3 3 0 Baculovirus P24 capsid protein DUF2489 PF10675.4 EWC48221.1 - 0.14 11.8 0.1 0.14 11.8 0.0 3.4 4 0 0 4 4 4 0 Protein of unknown function (DUF2489) Baculo_PEP_C PF04513.7 EWC48221.1 - 1.2 8.9 4.0 5.6 6.7 0.2 3.3 2 1 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DNA_ligase_A_M PF01068.16 EWC48222.1 - 4e-50 169.9 0.0 1e-49 168.6 0.0 1.8 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.9 EWC48222.1 - 3.3e-35 121.4 0.0 6.9e-35 120.4 0.0 1.5 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.10 EWC48222.1 - 1.4e-16 60.7 0.0 4.9e-16 58.9 0.0 2.0 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region BRCT PF00533.21 EWC48222.1 - 2.4e-06 27.6 0.1 1.3e-05 25.2 0.1 2.4 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain Clathrin PF00637.15 EWC48223.1 - 1.4e-21 76.5 0.7 9.4e-20 70.6 0.0 2.6 2 1 0 2 2 2 1 Region in Clathrin and VPS WD40 PF00400.27 EWC48223.1 - 2.5e-06 27.1 5.7 0.0011 18.7 0.2 4.2 4 0 0 4 4 4 1 WD domain, G-beta repeat zf-RING_2 PF13639.1 EWC48223.1 - 7.8e-05 22.4 0.4 0.00017 21.3 0.3 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 EWC48223.1 - 0.0023 17.9 0.7 0.005 16.8 0.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 EWC48223.1 - 0.0024 17.9 0.0 0.0053 16.8 0.0 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_5 PF14634.1 EWC48223.1 - 0.004 16.8 0.7 0.0078 15.9 0.5 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.20 EWC48223.1 - 0.0058 16.2 0.3 0.013 15.1 0.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Vps39_1 PF10366.4 EWC48223.1 - 0.12 12.3 0.2 1 9.4 0.0 2.3 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 1 BSP_II PF05432.6 EWC48223.1 - 0.21 10.8 9.6 0.25 10.5 2.8 2.4 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) zf-RING_UBOX PF13445.1 EWC48223.1 - 0.25 11.0 0.5 0.59 9.9 0.3 1.6 1 0 0 1 1 1 0 RING-type zinc-finger PHD PF00628.24 EWC48223.1 - 0.27 10.9 0.2 0.55 9.9 0.1 1.5 1 0 0 1 1 1 0 PHD-finger zf-C3HC4_4 PF15227.1 EWC48223.1 - 0.41 10.5 0.2 1 9.2 0.1 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING FAM176 PF14851.1 EWC48223.1 - 5.1 6.7 8.5 1.1 8.9 0.0 2.8 3 0 0 3 3 3 0 FAM176 family Apc1 PF12859.2 EWC48224.1 - 2.2e-12 47.1 1.3 3.7e-10 39.9 0.3 2.8 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 1 PC_rep PF01851.17 EWC48224.1 - 3.2e-05 23.9 1.3 0.095 12.9 0.0 3.7 3 0 0 3 3 3 2 Proteasome/cyclosome repeat Ribosomal_S26e PF01283.14 EWC48225.1 - 1.5e-45 154.0 9.1 1.6e-44 150.8 6.3 1.9 1 1 0 1 1 1 1 Ribosomal protein S26e DUF1918 PF08940.6 EWC48225.1 - 0.028 13.7 0.0 0.049 12.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1918) Fer4_7 PF12838.2 EWC48225.1 - 0.037 14.3 0.5 1.8 9.0 0.3 2.3 2 0 0 2 2 2 0 4Fe-4S dicluster domain Zn_ribbon_2 PF12674.2 EWC48225.1 - 0.086 13.1 0.1 16 5.9 0.0 2.3 2 0 0 2 2 2 0 Putative zinc ribbon domain CBS PF00571.23 EWC48226.1 - 1.9e-37 126.8 13.4 1.4e-09 37.5 0.0 5.4 6 0 0 6 6 6 4 CBS domain PB1 PF00564.19 EWC48226.1 - 6.6e-10 38.5 0.0 2.5e-09 36.6 0.0 2.1 2 0 0 2 2 2 1 PB1 domain Mito_fiss_reg PF05308.6 EWC48226.1 - 0.0098 15.2 1.7 0.021 14.2 1.1 1.5 1 0 0 1 1 1 1 Mitochondrial fission regulator HEAT PF02985.17 EWC48227.1 - 9.5e-26 87.5 7.0 0.044 13.8 0.0 12.1 11 0 0 11 11 11 6 HEAT repeat HEAT_2 PF13646.1 EWC48227.1 - 9.5e-24 83.5 8.6 2.7e-05 24.3 0.1 8.6 4 3 5 10 10 9 8 HEAT repeats HEAT_EZ PF13513.1 EWC48227.1 - 2.1e-16 59.8 20.4 1.2e-05 25.5 0.0 9.0 8 2 2 10 10 9 5 HEAT-like repeat Vac14_Fab1_bd PF12755.2 EWC48227.1 - 3.4e-09 36.9 0.8 0.41 11.0 0.0 7.0 3 3 5 8 8 8 2 Vacuolar 14 Fab1-binding region MMS19_C PF12460.3 EWC48227.1 - 2.7e-08 32.9 0.0 0.00015 20.6 0.0 4.4 3 2 2 5 5 5 1 RNAPII transcription regulator C-terminal RIX1 PF08167.7 EWC48227.1 - 2e-06 27.5 0.0 0.066 12.8 0.0 3.9 2 1 1 3 3 3 2 rRNA processing/ribosome biogenesis Xpo1 PF08389.7 EWC48227.1 - 6e-06 26.2 0.0 0.006 16.5 0.0 4.1 3 0 0 3 3 3 1 Exportin 1-like protein Adaptin_N PF01602.15 EWC48227.1 - 1.9e-05 23.2 0.1 0.028 12.7 0.0 4.0 3 1 0 4 4 4 1 Adaptin N terminal region TFCD_C PF12612.3 EWC48227.1 - 7.5e-05 22.2 0.2 0.34 10.3 0.0 5.0 5 2 1 6 6 6 1 Tubulin folding cofactor D C terminal CLASP_N PF12348.3 EWC48227.1 - 9.9e-05 21.7 0.7 0.008 15.5 0.0 4.3 4 2 1 5 5 5 1 CLASP N terminal Arm PF00514.18 EWC48227.1 - 0.00015 21.4 5.4 0.44 10.4 0.1 5.1 6 0 0 6 6 6 2 Armadillo/beta-catenin-like repeat Proteasom_PSMB PF10508.4 EWC48227.1 - 0.0023 16.2 0.4 0.024 12.9 0.1 2.7 2 1 1 3 3 3 1 Proteasome non-ATPase 26S subunit DUF3385 PF11865.3 EWC48227.1 - 0.0026 17.7 0.0 1.3 8.9 0.0 4.5 2 1 1 4 4 4 1 Domain of unknown function (DUF3385) DUF4598 PF15370.1 EWC48228.1 - 5.1e-09 36.4 10.6 5e-05 23.5 0.3 3.0 1 1 2 3 3 3 2 Domain of unknown function (DUF4598) Rhomboid PF01694.17 EWC48228.1 - 1.1e-08 35.2 10.6 2.2e-08 34.2 7.4 1.4 1 0 0 1 1 1 1 Rhomboid family NIF PF03031.13 EWC48229.1 - 4.1e-23 81.7 0.0 8.3e-23 80.7 0.0 1.5 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase PTCB-BRCT PF12738.2 EWC48229.1 - 2.7e-09 36.7 0.1 5.4e-09 35.7 0.1 1.6 1 0 0 1 1 1 1 twin BRCT domain BRCT PF00533.21 EWC48229.1 - 9.7e-09 35.2 0.0 4.8e-08 33.0 0.0 2.3 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain Folliculin PF11704.3 EWC48230.1 - 2.2e-36 124.9 0.1 1.2e-35 122.5 0.0 2.0 2 0 0 2 2 2 1 Vesicle coat protein involved in Golgi to plasma membrane transport Clp1 PF06807.9 EWC48231.1 - 8.8e-05 22.3 0.0 0.003 17.3 0.0 2.5 1 1 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 MobB PF03205.9 EWC48231.1 - 0.014 15.0 0.0 0.025 14.2 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Zeta_toxin PF06414.7 EWC48231.1 - 0.019 14.0 0.3 0.039 13.0 0.0 1.6 2 0 0 2 2 2 0 Zeta toxin AAA_16 PF13191.1 EWC48231.1 - 0.032 14.2 0.0 0.15 12.0 0.0 2.1 1 1 0 1 1 1 0 AAA ATPase domain RNA_polI_A34 PF08208.6 EWC48232.1 - 1.9e-20 73.3 35.4 1.9e-20 73.3 24.6 4.0 2 2 0 2 2 2 1 DNA-directed RNA polymerase I subunit RPA34.5 Prefoldin_2 PF01920.15 EWC48233.1 - 7.1e-20 70.7 22.0 2.7e-19 68.8 15.3 1.7 1 1 0 1 1 1 1 Prefoldin subunit Prefoldin_3 PF13758.1 EWC48233.1 - 0.0015 18.2 4.3 0.0015 18.2 3.0 1.8 1 1 0 1 1 1 1 Prefoldin subunit DUF972 PF06156.8 EWC48233.1 - 0.0068 16.7 8.3 1 9.7 3.6 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF972) Cob_adeno_trans PF01923.13 EWC48233.1 - 0.24 11.1 3.9 0.29 10.9 2.7 1.2 1 0 0 1 1 1 0 Cobalamin adenosyltransferase Atg14 PF10186.4 EWC48233.1 - 0.26 10.1 12.1 0.32 9.9 8.4 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 IncA PF04156.9 EWC48233.1 - 0.28 10.7 19.7 0.68 9.5 13.6 1.5 1 1 0 1 1 1 0 IncA protein TcdA_TcdB PF12919.2 EWC48233.1 - 0.32 9.4 7.5 0.41 9.0 5.2 1.2 1 0 0 1 1 1 0 TcdA/TcdB catalytic glycosyltransferase domain Prefoldin PF02996.12 EWC48233.1 - 0.4 10.3 13.9 0.13 11.8 5.7 2.3 2 0 0 2 2 2 0 Prefoldin subunit DUF4164 PF13747.1 EWC48233.1 - 0.4 10.8 10.7 0.18 11.9 0.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) FCP1_C PF09309.5 EWC48233.1 - 0.42 9.8 6.0 0.26 10.5 3.2 1.3 1 1 0 1 1 1 0 FCP1, C-terminal NPV_P10 PF05531.7 EWC48233.1 - 0.45 10.8 9.1 3.5 7.9 0.6 2.3 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein ERp29 PF07749.7 EWC48233.1 - 0.67 10.6 4.8 0.61 10.7 2.2 1.9 1 1 0 1 1 1 0 Endoplasmic reticulum protein ERp29, C-terminal domain DUF1040 PF06288.8 EWC48233.1 - 0.77 10.0 4.8 0.3 11.3 0.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1040) APG6 PF04111.7 EWC48233.1 - 0.84 8.6 16.5 0.99 8.3 10.4 1.6 1 1 1 2 2 2 0 Autophagy protein Apg6 Macoilin PF09726.4 EWC48233.1 - 0.89 7.7 11.6 0.97 7.6 8.1 1.0 1 0 0 1 1 1 0 Transmembrane protein Spc7 PF08317.6 EWC48233.1 - 0.97 8.0 15.0 1.2 7.6 10.4 1.0 1 0 0 1 1 1 0 Spc7 kinetochore protein CENP-H PF05837.7 EWC48233.1 - 2.1 8.5 12.1 1.1 9.4 4.3 2.1 2 0 0 2 2 2 0 Centromere protein H (CENP-H) Occludin_ELL PF07303.8 EWC48233.1 - 4.5 8.0 13.3 3.6 8.3 0.6 2.1 1 1 1 2 2 2 0 Occludin homology domain DUF1192 PF06698.6 EWC48233.1 - 5.2 6.9 8.9 2.4 8.0 0.3 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1192) Snf7 PF03357.16 EWC48233.1 - 5.8 6.2 19.7 0.23 10.8 8.0 2.0 1 1 1 2 2 2 0 Snf7 Allexi_40kDa PF05549.6 EWC48233.1 - 6.2 6.0 6.2 14 4.8 3.9 1.7 1 1 1 2 2 2 0 Allexivirus 40kDa protein Spc24 PF08286.6 EWC48233.1 - 9.5 5.9 17.0 3.8 7.2 1.6 2.2 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 AAA PF00004.24 EWC48234.1 - 6.9e-43 146.0 0.0 1.2e-42 145.2 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) MIT PF04212.13 EWC48234.1 - 1.1e-22 79.6 4.0 3.8e-22 77.9 2.4 2.2 2 0 0 2 2 2 1 MIT (microtubule interacting and transport) domain AAA_17 PF13207.1 EWC48234.1 - 1.4e-06 29.0 0.1 9e-06 26.5 0.0 2.2 2 1 0 2 2 2 1 AAA domain Vps4_C PF09336.5 EWC48234.1 - 2e-06 27.5 0.1 8.1e-06 25.6 0.0 2.1 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain AAA_22 PF13401.1 EWC48234.1 - 2.5e-05 24.4 0.1 0.0015 18.6 0.1 2.6 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.12 EWC48234.1 - 2.8e-05 23.6 0.0 5.1e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein RuvB_N PF05496.7 EWC48234.1 - 4.2e-05 22.7 0.0 6.2e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus RNA_helicase PF00910.17 EWC48234.1 - 5e-05 23.4 0.1 0.0077 16.3 0.0 3.1 3 0 0 3 3 3 1 RNA helicase AAA_16 PF13191.1 EWC48234.1 - 6e-05 23.1 0.1 0.0032 17.4 0.0 2.7 2 1 1 3 3 3 1 AAA ATPase domain AAA_5 PF07728.9 EWC48234.1 - 7.9e-05 22.4 0.0 0.00025 20.7 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.8 EWC48234.1 - 0.0001 21.1 0.0 0.00017 20.4 0.0 1.3 1 0 0 1 1 1 1 TIP49 C-terminus AAA_2 PF07724.9 EWC48234.1 - 0.00012 22.0 0.0 0.014 15.2 0.0 2.3 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_33 PF13671.1 EWC48234.1 - 0.00012 21.9 0.0 0.0011 18.8 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.1 EWC48234.1 - 0.00013 21.8 0.0 0.00031 20.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.1 EWC48234.1 - 0.00017 21.0 0.1 0.21 10.9 0.1 2.5 1 1 1 2 2 2 2 AAA domain DUF815 PF05673.8 EWC48234.1 - 0.0002 20.3 0.0 0.00071 18.5 0.0 1.9 1 1 1 2 2 2 1 Protein of unknown function (DUF815) AAA_24 PF13479.1 EWC48234.1 - 0.0038 16.8 0.1 0.024 14.2 0.0 2.2 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.7 EWC48234.1 - 0.0043 16.1 0.1 0.15 11.1 0.0 2.6 1 1 1 2 2 2 1 Zeta toxin Torsin PF06309.6 EWC48234.1 - 0.0056 16.5 0.0 0.057 13.2 0.0 2.1 2 0 0 2 2 2 1 Torsin AAA_18 PF13238.1 EWC48234.1 - 0.0065 16.7 0.3 0.02 15.1 0.0 1.9 2 0 0 2 2 2 1 AAA domain PhoH PF02562.11 EWC48234.1 - 0.014 14.6 0.1 0.06 12.5 0.0 2.0 2 0 0 2 2 2 0 PhoH-like protein Mg_chelatase PF01078.16 EWC48234.1 - 0.02 14.0 0.0 0.056 12.5 0.0 1.7 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI ResIII PF04851.10 EWC48234.1 - 0.022 14.6 0.1 0.069 12.9 0.0 1.8 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_19 PF13245.1 EWC48234.1 - 0.022 14.4 0.0 0.06 13.0 0.0 1.7 1 0 0 1 1 1 0 Part of AAA domain NACHT PF05729.7 EWC48234.1 - 0.024 14.3 0.0 0.57 9.8 0.0 2.2 1 1 1 2 2 2 0 NACHT domain Arch_ATPase PF01637.13 EWC48234.1 - 0.046 13.4 1.5 0.43 10.2 0.0 2.6 2 1 1 3 3 3 0 Archaeal ATPase Parvo_NS1 PF01057.12 EWC48234.1 - 0.061 12.1 0.0 0.11 11.2 0.0 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_28 PF13521.1 EWC48234.1 - 0.097 12.6 0.0 0.23 11.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain KaiC PF06745.8 EWC48234.1 - 0.11 11.6 0.0 6.7 5.7 0.0 2.3 1 1 1 2 2 2 0 KaiC AAA_21 PF13304.1 EWC48234.1 - 0.15 11.9 2.3 2.5 7.9 0.0 2.7 2 1 1 3 3 3 0 AAA domain CoA_trans PF01144.18 EWC48235.1 - 6.6e-101 335.9 3.2 1.6e-65 220.3 0.2 2.1 2 0 0 2 2 2 2 Coenzyme A transferase Glyoxalase_2 PF12681.2 EWC48236.1 - 4.5e-08 33.6 0.0 5.4e-08 33.4 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain Gaa1 PF04114.9 EWC48237.1 - 1e-97 327.9 20.2 1.5e-96 324.1 14.0 2.4 1 1 0 1 1 1 1 Gaa1-like, GPI transamidase component zf-C2H2_jaz PF12171.3 EWC48238.1 - 3.4e-05 23.8 3.4 8.7e-05 22.5 1.1 2.1 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.2 EWC48238.1 - 0.0076 16.3 0.2 0.011 15.8 0.1 1.2 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-met PF12874.2 EWC48238.1 - 0.3 11.3 3.7 0.19 11.9 0.8 1.9 2 0 0 2 2 2 0 Zinc-finger of C2H2 type Aconitase PF00330.15 EWC48239.1 - 3.3e-177 589.6 0.0 6.5e-177 588.6 0.0 1.4 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.14 EWC48239.1 - 5.1e-47 159.2 0.0 9.6e-47 158.3 0.0 1.5 1 0 0 1 1 1 1 Aconitase C-terminal domain CRAL_TRIO PF00650.15 EWC48240.1 - 1.4e-34 118.9 0.1 3.5e-26 91.6 0.0 2.4 1 1 1 2 2 2 2 CRAL/TRIO domain CRAL_TRIO_N PF03765.10 EWC48240.1 - 6.6e-15 54.9 0.1 6.6e-15 54.9 0.1 2.3 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.1 EWC48240.1 - 2.5e-07 30.7 0.0 6.2e-06 26.1 0.0 2.4 2 1 0 2 2 2 1 Divergent CRAL/TRIO domain DUF1394 PF07159.7 EWC48241.1 - 0.0015 17.7 0.1 0.0019 17.3 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1394) Apolipoprotein PF01442.13 EWC48241.1 - 0.0091 15.5 3.1 0.012 15.1 2.2 1.2 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain FH2 PF02181.18 EWC48241.1 - 0.062 12.1 0.2 0.08 11.8 0.1 1.1 1 0 0 1 1 1 0 Formin Homology 2 Domain SOG2 PF10428.4 EWC48241.1 - 0.069 11.8 1.1 0.082 11.5 0.8 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein DASH_Spc19 PF08287.6 EWC48241.1 - 0.086 12.4 3.4 0.45 10.1 0.4 2.1 1 1 1 2 2 2 0 Spc19 GTPase_Cys_C PF12631.2 EWC48241.1 - 0.14 12.5 1.4 1.9 8.9 0.4 2.2 2 0 0 2 2 2 0 Catalytic cysteine-containing C-terminus of GTPase, MnmE NPV_P10 PF05531.7 EWC48241.1 - 0.33 11.2 2.5 0.43 10.8 0.6 2.0 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF3763 PF12592.3 EWC48241.1 - 3.7 7.2 5.7 7.5 6.2 0.3 3.2 4 0 0 4 4 4 0 Protein of unknown function (DUF3763) Rsa3 PF14615.1 EWC48242.1 - 4.4e-17 61.0 0.0 6.7e-17 60.5 0.0 1.3 1 0 0 1 1 1 1 Ribosome-assembly protein 3 Nop14 PF04147.7 EWC48242.1 - 0.012 13.5 29.6 0.016 13.1 20.5 1.1 1 0 0 1 1 1 0 Nop14-like family Myc_N PF01056.13 EWC48242.1 - 3.2 6.8 35.8 0.25 10.4 8.9 2.2 1 1 1 2 2 2 0 Myc amino-terminal region Utp14 PF04615.8 EWC48242.1 - 3.9 5.5 27.8 5 5.1 19.2 1.2 1 0 0 1 1 1 0 Utp14 protein BUD22 PF09073.5 EWC48242.1 - 3.9 6.4 37.4 6.1 5.7 25.9 1.3 1 0 0 1 1 1 0 BUD22 Mitofilin PF09731.4 EWC48242.1 - 5.7 5.4 22.2 7.1 5.1 15.4 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein KIAA1328 PF15369.1 EWC48242.1 - 8.9 6.0 21.4 11 5.6 14.8 1.1 1 0 0 1 1 1 0 Uncharacterised protein KIAA1328 AvrE PF11725.3 EWC48242.1 - 9.6 3.0 26.1 11 2.8 18.1 1.0 1 0 0 1 1 1 0 Pathogenicity factor Glyco_hydro_72 PF03198.9 EWC48243.1 - 1e-130 435.3 0.6 1.3e-130 434.9 0.4 1.1 1 0 0 1 1 1 1 Glucanosyltransferase X8 PF07983.8 EWC48243.1 - 7.2e-21 74.4 5.1 1.8e-20 73.1 2.9 2.2 2 0 0 2 2 2 1 X8 domain Cellulase PF00150.13 EWC48243.1 - 0.00041 19.6 0.4 0.011 14.9 0.3 2.3 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glucan_synthase PF02364.10 EWC48244.1 - 0 1463.5 0.0 0 1463.1 0.0 1.2 1 0 0 1 1 1 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.1 EWC48244.1 - 2e-40 137.3 0.7 5.1e-40 136.0 0.5 1.7 1 0 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 Wbp11 PF09429.5 EWC48244.1 - 0.58 10.1 7.2 0.69 9.9 2.3 2.2 2 0 0 2 2 2 0 WW domain binding protein 11 SGT1 PF07093.6 EWC48246.1 - 1.9e-129 432.7 21.0 1.1e-112 377.3 0.0 2.1 1 1 0 2 2 2 2 SGT1 protein MFS_1 PF07690.11 EWC48247.1 - 2.1e-22 79.3 37.3 1.3e-11 43.7 13.0 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily ATG22 PF11700.3 EWC48247.1 - 4.4e-07 28.7 21.3 0.0013 17.2 0.1 3.3 2 1 1 3 3 3 3 Vacuole effluxer Atg22 like Sugar_tr PF00083.19 EWC48247.1 - 0.0009 17.9 7.6 0.0009 17.9 5.3 2.6 2 1 1 3 3 3 2 Sugar (and other) transporter OATP PF03137.15 EWC48247.1 - 0.02 12.9 5.7 0.067 11.2 0.5 2.7 3 1 0 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family UNC-93 PF05978.11 EWC48247.1 - 0.1 12.0 4.0 0.13 11.7 1.0 2.3 2 0 0 2 2 2 0 Ion channel regulatory protein UNC-93 MFS_1_like PF12832.2 EWC48247.1 - 0.45 10.3 8.2 0.58 9.9 0.2 3.4 4 0 0 4 4 4 0 MFS_1 like family Bromodomain PF00439.20 EWC48248.1 - 6.4e-19 67.6 0.3 1.6e-18 66.4 0.2 1.6 1 0 0 1 1 1 1 Bromodomain Bromo_TP PF07524.8 EWC48248.1 - 7.5e-08 32.0 0.0 1.7e-07 30.8 0.0 1.6 1 0 0 1 1 1 1 Bromodomain associated GRAM PF02893.15 EWC48249.1 - 1.4e-26 91.7 0.5 2.8e-14 52.3 0.0 3.4 3 0 0 3 3 3 3 GRAM domain Glyco_transf_28 PF03033.15 EWC48249.1 - 1.5e-25 89.5 0.0 3.7e-25 88.3 0.0 1.7 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain PH PF00169.24 EWC48249.1 - 1.4e-14 54.1 0.1 2.2e-13 50.2 0.0 2.9 3 0 0 3 3 3 1 PH domain UDPGT PF00201.13 EWC48249.1 - 3.1e-05 22.7 0.0 6.7e-05 21.6 0.0 1.5 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase PH_8 PF15409.1 EWC48249.1 - 0.0016 18.4 0.1 0.0043 17.0 0.1 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain PH_6 PF15406.1 EWC48249.1 - 0.0021 18.0 0.0 0.017 15.1 0.0 2.5 2 0 0 2 2 2 1 Pleckstrin homology domain Mog1 PF04603.7 EWC48250.1 - 3.9e-20 72.2 0.0 5.3e-20 71.7 0.0 1.2 1 0 0 1 1 1 1 Ran-interacting Mog1 protein SnoaL PF07366.7 EWC48251.1 - 3.1e-20 72.0 0.0 3.6e-20 71.8 0.0 1.0 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase SnoaL_2 PF12680.2 EWC48251.1 - 1.9e-11 44.2 0.0 2.4e-11 43.9 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain SprT-like PF10263.4 EWC48252.1 - 2.8e-22 79.0 1.4 5.1e-22 78.2 1.0 1.4 1 0 0 1 1 1 1 SprT-like family Zn-ribbon_8 PF09723.5 EWC48252.1 - 0.053 13.4 1.9 0.15 12.0 1.3 1.8 1 0 0 1 1 1 0 Zinc ribbon domain HMG_box PF00505.14 EWC48252.1 - 0.054 13.7 0.0 0.19 12.0 0.0 1.9 2 0 0 2 2 2 0 HMG (high mobility group) box TPR_11 PF13414.1 EWC48253.1 - 1.2e-53 178.5 21.6 1.5e-07 30.9 0.0 11.7 10 1 1 11 11 11 10 TPR repeat TPR_16 PF13432.1 EWC48253.1 - 2.9e-34 116.9 38.2 2.6e-05 24.7 0.0 12.9 10 4 2 13 13 13 8 Tetratricopeptide repeat TPR_2 PF07719.12 EWC48253.1 - 1.4e-30 102.7 33.4 0.00043 19.9 0.0 17.4 19 0 0 19 19 17 7 Tetratricopeptide repeat TPR_14 PF13428.1 EWC48253.1 - 1.9e-30 102.5 35.5 0.035 14.7 0.0 18.3 13 7 8 21 21 18 9 Tetratricopeptide repeat TPR_1 PF00515.23 EWC48253.1 - 2.1e-30 103.0 11.4 5.6e-05 22.5 0.0 13.9 14 0 0 14 14 14 5 Tetratricopeptide repeat TPR_19 PF14559.1 EWC48253.1 - 6.3e-28 96.9 32.5 2.2e-05 24.6 0.0 12.8 12 2 2 14 14 14 7 Tetratricopeptide repeat TPR_17 PF13431.1 EWC48253.1 - 3.6e-26 89.1 14.0 0.006 16.6 0.0 12.8 15 0 0 15 15 14 6 Tetratricopeptide repeat TPR_8 PF13181.1 EWC48253.1 - 3.3e-21 73.4 11.6 0.0029 17.2 0.0 13.7 15 1 1 16 16 15 5 Tetratricopeptide repeat TPR_6 PF13174.1 EWC48253.1 - 4.8e-14 51.7 18.2 11 6.6 0.0 15.2 18 1 0 18 18 16 0 Tetratricopeptide repeat TPR_12 PF13424.1 EWC48253.1 - 1.5e-13 50.4 37.6 0.022 14.7 0.1 11.3 7 6 4 12 12 12 7 Tetratricopeptide repeat TPR_7 PF13176.1 EWC48253.1 - 2.4e-10 39.4 11.5 0.16 11.8 0.0 11.5 12 1 1 13 13 13 1 Tetratricopeptide repeat TPR_9 PF13371.1 EWC48253.1 - 4e-10 39.3 3.7 0.047 13.5 0.0 7.9 4 3 3 8 8 8 1 Tetratricopeptide repeat ChAPs PF09295.5 EWC48253.1 - 2.8e-05 23.0 3.2 0.92 8.1 0.0 5.1 5 1 0 5 5 5 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_20 PF14561.1 EWC48253.1 - 0.0017 18.4 14.1 0.69 10.0 0.0 7.8 6 3 1 8 8 8 1 Tetratricopeptide repeat TPR_10 PF13374.1 EWC48253.1 - 0.0055 16.6 13.5 8.5 6.4 0.0 8.3 7 1 1 8 8 8 1 Tetratricopeptide repeat MRFAP1 PF15155.1 EWC48253.1 - 0.67 10.2 3.9 1.7 9.0 0.1 3.3 3 0 0 3 3 3 0 MORF4 family-associated protein1 2-Hacid_dh_C PF02826.14 EWC48254.1 - 2.6e-49 166.7 0.0 4e-49 166.1 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 EWC48254.1 - 9.2e-16 57.5 0.0 1.6e-15 56.7 0.0 1.3 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.10 EWC48254.1 - 0.00093 19.0 0.0 0.002 17.9 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase adh_short PF00106.20 EWC48255.1 - 1.5e-10 41.2 0.0 1.5e-08 34.7 0.0 2.3 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EWC48255.1 - 1.3e-07 31.6 0.0 2.3e-07 30.8 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Elong_Iki1 PF10483.4 EWC48256.1 - 1.4e-67 228.0 0.0 1.8e-67 227.6 0.0 1.1 1 0 0 1 1 1 1 Elongator subunit Iki1 CLPTM1 PF05602.7 EWC48257.1 - 2e-137 458.5 3.2 2.6e-137 458.1 2.2 1.1 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) DUF1462 PF07315.6 EWC48257.1 - 0.074 13.0 0.1 6.7 6.7 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1462) 2TM PF13239.1 EWC48257.1 - 0.19 11.8 3.3 0.4 10.7 0.4 2.7 2 0 0 2 2 2 0 2TM domain DUF1240 PF06836.7 EWC48257.1 - 0.19 11.9 3.7 0.7 10.1 2.6 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1240) Ras PF00071.17 EWC48258.1 - 1.2e-48 164.5 0.4 1.3e-48 164.4 0.3 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EWC48258.1 - 1.3e-15 57.8 0.3 1.8e-15 57.4 0.2 1.2 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 EWC48258.1 - 7.9e-06 25.8 0.0 1.3e-05 25.1 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.16 EWC48258.1 - 0.00021 20.5 0.1 0.00025 20.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.5 EWC48258.1 - 0.00024 20.3 0.1 0.00031 20.0 0.1 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.22 EWC48258.1 - 0.00028 20.3 0.1 0.0076 15.6 0.1 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.13 EWC48258.1 - 0.0024 17.1 0.0 0.038 13.2 0.0 2.1 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_14 PF13173.1 EWC48258.1 - 0.0069 16.2 0.0 0.01 15.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain Arch_ATPase PF01637.13 EWC48258.1 - 0.018 14.7 0.2 0.031 13.9 0.1 1.6 1 1 0 1 1 1 0 Archaeal ATPase G10 PF01125.12 EWC48259.1 - 1e-62 209.9 3.0 1.1e-62 209.8 2.1 1.0 1 0 0 1 1 1 1 G10 protein Fes1 PF08609.5 EWC48260.1 - 2.3e-26 92.0 2.0 7e-26 90.5 0.5 2.1 2 0 0 2 2 2 1 Nucleotide exchange factor Fes1 HEAT_2 PF13646.1 EWC48260.1 - 2.1e-06 27.8 0.1 8e-06 26.0 0.1 1.9 1 1 0 1 1 1 1 HEAT repeats HEAT_EZ PF13513.1 EWC48260.1 - 5.5e-06 26.7 0.2 8.4e-05 22.9 0.0 2.8 3 1 1 4 4 4 1 HEAT-like repeat HEAT PF02985.17 EWC48260.1 - 0.00015 21.5 0.1 0.46 10.6 0.0 3.2 3 0 0 3 3 3 2 HEAT repeat Arm PF00514.18 EWC48260.1 - 0.00019 21.1 0.1 0.0035 17.1 0.0 2.8 3 0 0 3 3 3 1 Armadillo/beta-catenin-like repeat V-ATPase_H_C PF11698.3 EWC48260.1 - 0.055 13.3 0.6 0.12 12.3 0.1 1.7 2 0 0 2 2 2 0 V-ATPase subunit H Methyltrans_Mon PF14314.1 EWC48260.1 - 0.082 10.7 0.1 0.1 10.4 0.1 1.0 1 0 0 1 1 1 0 Virus-capping methyltransferase DUF3321 PF11968.3 EWC48261.1 - 1.6e-65 220.8 0.0 1.1e-40 139.5 0.0 2.2 2 0 0 2 2 2 2 Putative methyltransferase (DUF3321) Methyltransf_23 PF13489.1 EWC48261.1 - 7.5e-05 22.5 0.0 0.00013 21.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain K-cyclin_vir_C PF09080.5 EWC48261.1 - 0.1 12.8 0.1 0.25 11.5 0.0 1.6 2 0 0 2 2 2 0 K cyclin, C terminal Methyltransf_12 PF08242.7 EWC48261.1 - 0.13 12.7 0.0 0.29 11.6 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain PBD PF00786.23 EWC48262.1 - 7.1e-13 48.7 0.6 1.6e-12 47.6 0.0 1.8 2 1 0 2 2 2 1 P21-Rho-binding domain Pheromone PF08015.6 EWC48262.1 - 0.035 14.9 2.8 0.035 14.9 2.0 1.8 2 1 0 2 2 2 0 Fungal mating-type pheromone Fork_head PF00250.13 EWC48263.1 - 3.6e-33 113.4 0.4 7.7e-33 112.4 0.3 1.5 1 0 0 1 1 1 1 Fork head domain SPC12 PF06645.8 EWC48264.1 - 9.3e-24 83.0 0.0 1.2e-23 82.6 0.0 1.1 1 0 0 1 1 1 1 Microsomal signal peptidase 12 kDa subunit (SPC12) PhoH PF02562.11 EWC48264.1 - 0.13 11.4 0.0 0.14 11.3 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein DUF348 PF03990.9 EWC48264.1 - 0.25 10.9 1.7 0.44 10.1 1.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF348) Pkinase PF00069.20 EWC48265.1 - 1.9e-67 227.1 0.0 2.2e-67 226.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC48265.1 - 1.2e-31 109.7 0.0 1.6e-31 109.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EWC48265.1 - 4.4e-06 25.8 0.0 0.0045 15.9 0.0 2.3 2 1 0 2 2 2 2 Kinase-like Kdo PF06293.9 EWC48265.1 - 0.0027 16.8 0.0 0.0043 16.1 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Elf1 PF05129.8 EWC48267.1 - 0.0092 15.6 0.1 0.014 15.0 0.0 1.3 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like UPRTase PF14681.1 EWC48268.1 - 1.8e-82 275.5 0.0 2.1e-82 275.3 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.22 EWC48268.1 - 0.00037 20.1 0.0 0.0006 19.5 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain CoA_binding_2 PF13380.1 EWC48268.1 - 0.033 14.3 0.0 0.18 11.9 0.0 1.9 1 1 1 2 2 2 0 CoA binding domain Flu_C_NS1 PF03506.8 EWC48268.1 - 0.064 12.9 0.1 0.098 12.3 0.1 1.2 1 0 0 1 1 1 0 Influenza C non-structural protein (NS1) GTP_CH_N PF12471.3 EWC48269.1 - 6.3e-89 296.7 0.0 9.6e-89 296.1 0.0 1.3 1 0 0 1 1 1 1 GTP cyclohydrolase N terminal GTP_cyclohydro2 PF00925.15 EWC48269.1 - 2e-17 62.9 0.0 3.2e-17 62.2 0.0 1.3 1 0 0 1 1 1 1 GTP cyclohydrolase II Herpes_BLRF2 PF05812.7 EWC48271.1 - 0.058 13.2 7.0 1.2 8.9 0.6 2.7 1 1 1 2 2 2 0 Herpesvirus BLRF2 protein DUF904 PF06005.7 EWC48271.1 - 0.31 11.3 8.1 4.5 7.6 5.6 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF904) DUF605 PF04652.11 EWC48271.1 - 0.7 9.2 19.0 1.1 8.5 13.2 1.4 1 0 0 1 1 1 0 Vta1 like DivIC PF04977.10 EWC48271.1 - 3.1 7.3 5.3 3.8 7.0 1.1 2.7 1 1 1 2 2 2 0 Septum formation initiator Phage_lysis PF03245.8 EWC48271.1 - 4 7.4 9.4 1.2 9.1 1.5 2.6 2 0 0 2 2 2 0 Bacteriophage Rz lysis protein HALZ PF02183.13 EWC48271.1 - 7.3 6.3 7.5 14 5.5 0.5 2.4 2 0 0 2 2 2 0 Homeobox associated leucine zipper Ribosomal_S3Ae PF01015.13 EWC48272.1 - 5.4e-81 270.5 5.8 6.5e-81 270.3 4.0 1.1 1 0 0 1 1 1 1 Ribosomal S3Ae family DUF1092 PF06485.6 EWC48272.1 - 0.11 11.4 0.5 0.18 10.6 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1092) zf-rbx1 PF12678.2 EWC48273.1 - 2.4e-35 120.4 13.4 2.9e-35 120.1 9.3 1.1 1 0 0 1 1 1 1 RING-H2 zinc finger zf-Apc11 PF12861.2 EWC48273.1 - 7.8e-17 60.9 9.9 1e-16 60.5 6.9 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.1 EWC48273.1 - 1.9e-07 30.8 12.2 1.2e-06 28.1 8.5 2.0 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 EWC48273.1 - 0.0012 18.4 11.8 0.021 14.4 8.2 2.4 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 EWC48273.1 - 0.0026 17.3 9.9 0.29 10.8 7.0 2.3 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 EWC48273.1 - 0.042 13.8 13.1 0.042 13.8 5.7 2.3 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.3 EWC48273.1 - 0.46 10.4 9.4 2.4 8.2 6.6 1.9 1 1 1 2 2 2 0 FANCL C-terminal domain zf-RING_5 PF14634.1 EWC48273.1 - 0.72 9.6 11.9 6.9 6.4 8.3 2.4 1 1 1 2 2 2 0 zinc-RING finger domain zf-RING_UBOX PF13445.1 EWC48273.1 - 0.73 9.6 7.0 0.92 9.2 1.6 2.3 1 1 1 2 2 2 0 RING-type zinc-finger zf-HC5HC2H PF13771.1 EWC48273.1 - 2.2 8.4 10.8 1.7e+02 2.4 7.6 2.2 1 1 0 1 1 1 0 PHD-like zinc-binding domain PNRC PF15365.1 EWC48274.1 - 2.7e-06 27.2 2.9 2.7e-06 27.2 2.0 3.3 3 0 0 3 3 3 1 Proline-rich nuclear receptor coactivator MaoC_dehydratas PF01575.14 EWC48275.1 - 0.021 14.2 0.0 0.041 13.2 0.0 1.4 1 0 0 1 1 1 0 MaoC like domain TFIIA PF03153.8 EWC48275.1 - 0.1 12.5 16.6 0.16 11.7 11.5 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Phosphodiest PF01663.17 EWC48276.1 - 8.9e-17 61.4 1.9 1.7e-15 57.2 1.3 2.1 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.18 EWC48276.1 - 4.8e-06 25.9 0.0 9.7e-06 24.9 0.0 1.5 1 0 0 1 1 1 1 Sulfatase Metalloenzyme PF01676.13 EWC48276.1 - 0.004 16.5 0.1 0.0094 15.3 0.0 1.6 1 1 0 1 1 1 1 Metalloenzyme superfamily DUF3481 PF11980.3 EWC48276.1 - 0.092 12.5 0.3 0.35 10.7 0.2 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3481) DUF229 PF02995.12 EWC48276.1 - 0.29 9.4 0.0 0.45 8.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF229) DUF3384 PF11864.3 EWC48277.1 - 8.2e-101 337.7 2.3 1.9e-100 336.5 1.5 1.7 1 1 1 2 2 2 1 Domain of unknown function (DUF3384) Rap_GAP PF02145.10 EWC48277.1 - 2.1e-59 200.1 0.0 3.7e-59 199.2 0.0 1.4 1 0 0 1 1 1 1 Rap/ran-GAP Tuberin PF03542.11 EWC48277.1 - 8.1e-32 110.6 1.3 3.3e-28 98.7 0.6 2.7 2 0 0 2 2 2 2 Tuberin Thoc2 PF11732.3 EWC48277.1 - 0.11 12.3 1.0 0.27 11.0 0.0 2.1 2 0 0 2 2 2 0 Transcription- and export-related complex subunit Aa_trans PF01490.13 EWC48278.1 - 8.3e-60 202.3 31.1 9.6e-60 202.1 21.6 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Thymidylat_synt PF00303.14 EWC48279.1 - 8.2e-114 379.1 0.0 9.2e-114 378.9 0.0 1.0 1 0 0 1 1 1 1 Thymidylate synthase TrmE_N PF10396.4 EWC48280.1 - 3.3e-20 72.1 0.0 9.8e-20 70.6 0.0 1.8 1 0 0 1 1 1 1 GTP-binding protein TrmE N-terminus MMR_HSR1 PF01926.18 EWC48280.1 - 1.4e-17 63.6 0.0 2.4e-17 62.9 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTPase_Cys_C PF12631.2 EWC48280.1 - 3.5e-14 52.9 1.8 2.4e-13 50.2 0.0 3.1 3 0 0 3 3 3 1 Catalytic cysteine-containing C-terminus of GTPase, MnmE FeoB_N PF02421.13 EWC48280.1 - 2.1e-05 23.8 0.3 0.0004 19.7 0.0 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.18 EWC48280.1 - 9.8e-05 22.2 0.0 0.00018 21.3 0.0 1.5 1 0 0 1 1 1 1 Dynamin family Miro PF08477.8 EWC48280.1 - 0.00039 20.8 0.0 0.0015 19.0 0.0 2.1 1 1 0 1 1 1 1 Miro-like protein MCM PF00493.18 EWC48280.1 - 0.0033 16.2 0.0 0.0057 15.5 0.0 1.3 1 0 0 1 1 1 1 MCM2/3/5 family GTP_EFTU PF00009.22 EWC48280.1 - 0.0041 16.5 0.3 0.26 10.7 0.1 2.2 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_28 PF13521.1 EWC48280.1 - 0.006 16.5 0.1 1.2 9.0 0.0 2.5 1 1 1 2 2 2 1 AAA domain DUF258 PF03193.11 EWC48280.1 - 0.0079 15.3 0.0 0.014 14.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Glyco_hydro_3_C PF01915.17 EWC48280.1 - 0.0099 15.4 0.8 0.012 15.0 0.5 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain DUF1995 PF09353.5 EWC48280.1 - 0.12 12.0 0.0 0.94 9.0 0.0 2.1 1 1 2 3 3 3 0 Domain of unknown function (DUF1995) AIG1 PF04548.11 EWC48280.1 - 0.12 11.4 0.1 0.22 10.5 0.1 1.4 1 0 0 1 1 1 0 AIG1 family AAA_16 PF13191.1 EWC48280.1 - 1.4 8.8 7.6 0.99 9.3 0.3 3.5 1 1 1 3 3 3 0 AAA ATPase domain RRM_1 PF00076.17 EWC48281.1 - 5.3e-32 109.2 0.0 2.6e-15 55.7 0.0 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EWC48281.1 - 8.2e-19 67.3 0.0 5e-10 39.2 0.0 2.1 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EWC48281.1 - 1.1e-13 50.7 0.0 7.3e-08 32.1 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) OB_RNB PF08206.6 EWC48281.1 - 0.0009 18.6 0.8 0.26 10.8 0.1 2.4 2 0 0 2 2 2 2 Ribonuclease B OB domain Limkain-b1 PF11608.3 EWC48281.1 - 0.0094 15.6 0.0 0.15 11.8 0.0 2.1 2 0 0 2 2 2 1 Limkain b1 Cas_Cas2CT1978 PF09707.5 EWC48281.1 - 0.02 14.8 0.0 1.8 8.5 0.0 2.3 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Cas2CT1978) Nup35_RRM_2 PF14605.1 EWC48281.1 - 0.031 14.0 0.0 0.31 10.8 0.0 2.2 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif BAF1_ABF1 PF04684.8 EWC48282.1 - 0.018 13.9 12.7 0.025 13.4 8.8 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor PBP_sp32 PF07222.7 EWC48282.1 - 0.69 9.0 13.5 1.1 8.4 9.3 1.3 1 0 0 1 1 1 0 Proacrosin binding protein sp32 Cse1 PF08506.5 EWC48283.1 - 6.3e-159 528.4 4.6 9.5e-159 527.8 3.2 1.3 1 0 0 1 1 1 1 Cse1 CAS_CSE1 PF03378.10 EWC48283.1 - 4.4e-137 456.9 0.0 3.5e-136 453.9 0.0 2.2 2 0 0 2 2 2 1 CAS/CSE protein, C-terminus IBN_N PF03810.14 EWC48283.1 - 2.1e-11 43.5 0.0 1.1e-10 41.3 0.0 2.4 1 0 0 1 1 1 1 Importin-beta N-terminal domain Xpo1 PF08389.7 EWC48283.1 - 0.039 13.8 3.7 7.4 6.4 0.0 4.2 5 0 0 5 5 5 0 Exportin 1-like protein V-ATPase_H_N PF03224.9 EWC48283.1 - 0.078 12.0 2.0 4.2 6.4 0.1 2.8 1 1 1 2 2 2 0 V-ATPase subunit H HEAT_2 PF13646.1 EWC48283.1 - 0.091 13.0 0.0 2.3 8.5 0.0 3.2 3 0 0 3 3 3 0 HEAT repeats RIX1 PF08167.7 EWC48283.1 - 0.1 12.2 0.6 2.3 7.8 0.1 3.0 2 0 0 2 2 2 0 rRNA processing/ribosome biogenesis Arm PF00514.18 EWC48283.1 - 0.12 12.2 0.0 9.8 6.1 0.0 3.1 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat PUF PF00806.14 EWC48284.1 - 2.5e-63 206.1 19.0 4.6e-09 35.2 0.0 8.6 9 0 0 9 9 9 8 Pumilio-family RNA binding repeat Tenui_NCP PF04876.7 EWC48284.1 - 0.0013 18.3 3.0 0.24 10.9 0.4 2.3 2 0 0 2 2 2 2 Tenuivirus major non-capsid protein Phosphodiest PF01663.17 EWC48286.1 - 4e-13 49.4 0.0 6.1e-13 48.8 0.0 1.2 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.13 EWC48286.1 - 0.0011 18.4 0.8 0.0017 17.7 0.6 1.2 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.18 EWC48286.1 - 0.0012 18.1 0.0 0.0019 17.4 0.0 1.3 1 0 0 1 1 1 1 Sulfatase Form-deh_trans PF09163.6 EWC48286.1 - 2.9 7.4 6.9 3.7 7.1 0.1 3.6 3 0 0 3 3 3 0 Formate dehydrogenase N, transmembrane CorA PF01544.13 EWC48287.1 - 7.3e-43 146.6 0.0 1.1e-42 146.1 0.0 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein Transcrip_reg PF01709.15 EWC48288.1 - 2.8e-30 105.1 0.0 3.4e-30 104.8 0.0 1.1 1 0 0 1 1 1 1 Transcriptional regulator HEAT PF02985.17 EWC48289.1 - 7.6e-12 44.2 16.1 0.03 14.3 0.0 10.8 11 0 0 11 11 11 4 HEAT repeat HEAT_2 PF13646.1 EWC48289.1 - 2.3e-10 40.6 7.9 1.1 9.5 0.0 7.7 5 2 2 7 7 7 5 HEAT repeats HEAT_EZ PF13513.1 EWC48289.1 - 2.9 8.5 16.0 51 4.5 0.0 8.2 9 1 0 9 9 9 0 HEAT-like repeat FH2 PF02181.18 EWC48290.1 - 3.5e-60 203.8 1.1 3.5e-60 203.8 0.8 1.7 2 0 0 2 2 2 1 Formin Homology 2 Domain Drf_GBD PF06371.8 EWC48290.1 - 6.1e-55 185.5 0.6 3.7e-54 182.9 0.0 2.7 3 0 0 3 3 3 1 Diaphanous GTPase-binding Domain Drf_FH3 PF06367.11 EWC48290.1 - 4.3e-45 153.5 2.9 1.4e-44 151.8 0.0 3.2 3 1 1 4 4 4 1 Diaphanous FH3 Domain YfaZ PF07437.6 EWC48290.1 - 0.12 11.8 0.0 0.2 11.0 0.0 1.3 1 0 0 1 1 1 0 YfaZ precursor Hus1 PF04005.7 EWC48292.1 - 5.5e-71 238.8 0.0 6.2e-71 238.7 0.0 1.0 1 0 0 1 1 1 1 Hus1-like protein PCNA_N PF00705.13 EWC48292.1 - 0.076 12.5 0.0 13 5.3 0.0 2.5 3 0 0 3 3 3 0 Proliferating cell nuclear antigen, N-terminal domain DUF2404 PF10296.4 EWC48293.1 - 2.1e-07 30.9 0.0 3.9e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 Putative integral membrane protein conserved region (DUF2404) APS_kinase PF01583.15 EWC48294.1 - 4.6e-67 224.5 0.0 6.3e-67 224.1 0.0 1.2 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_33 PF13671.1 EWC48294.1 - 9.8e-09 35.2 0.0 1.4e-08 34.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 EWC48294.1 - 1.2e-06 29.3 0.0 3.5e-06 27.8 0.0 1.7 1 1 1 2 2 2 1 AAA domain AAA_18 PF13238.1 EWC48294.1 - 6.3e-05 23.2 0.0 0.00016 21.9 0.0 1.7 2 0 0 2 2 2 1 AAA domain KTI12 PF08433.5 EWC48294.1 - 0.00074 18.8 0.0 0.00075 18.7 0.0 1.3 1 1 0 1 1 1 1 Chromatin associated protein KTI12 CPT PF07931.7 EWC48294.1 - 0.00093 18.8 0.2 0.011 15.4 0.1 2.3 1 1 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein AAA_29 PF13555.1 EWC48294.1 - 0.003 17.0 0.0 0.005 16.3 0.0 1.3 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.1 EWC48294.1 - 0.013 15.4 0.1 0.03 14.3 0.1 1.7 1 1 0 1 1 1 0 AAA ATPase domain Zeta_toxin PF06414.7 EWC48294.1 - 0.045 12.8 0.0 0.066 12.2 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_14 PF13173.1 EWC48294.1 - 0.12 12.3 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain 6PF2K PF01591.13 EWC48294.1 - 0.13 11.3 0.0 0.21 10.6 0.0 1.4 2 0 0 2 2 2 0 6-phosphofructo-2-kinase UPF0220 PF05255.6 EWC48295.1 - 3.5e-65 218.2 2.3 3.9e-65 218.1 1.6 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) DUF1777 PF08648.7 EWC48296.1 - 5.1e-22 78.4 49.1 5.1e-22 78.4 34.0 2.7 1 1 1 2 2 2 1 Protein of unknown function (DUF1777) Glyco_hydro_63 PF03200.11 EWC48297.1 - 1.2e-233 777.4 0.0 1.2e-232 774.1 0.0 1.9 1 1 0 1 1 1 1 Mannosyl oligosaccharide glucosidase Trehalase PF01204.13 EWC48297.1 - 6.7e-07 28.3 0.0 1.1e-06 27.6 0.0 1.2 1 0 0 1 1 1 1 Trehalase GDE_C PF06202.9 EWC48297.1 - 0.0039 15.9 0.0 0.0063 15.2 0.0 1.2 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase MMtag PF10159.4 EWC48298.1 - 3.6e-29 100.6 4.4 3.6e-29 100.6 3.0 2.6 2 1 1 3 3 3 1 Kinase phosphorylation protein Histone PF00125.19 EWC48299.1 - 1.1e-28 99.1 0.5 2.7e-28 97.8 0.4 1.6 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 EWC48299.1 - 0.00038 20.4 0.6 0.00073 19.5 0.4 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-S PF15630.1 EWC48299.1 - 0.00058 20.0 0.2 0.00096 19.2 0.1 1.4 1 0 0 1 1 1 1 Kinetochore component CENP-S CENP-T PF15511.1 EWC48299.1 - 0.0066 15.7 0.5 0.012 14.8 0.0 1.6 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T L71 PF02448.10 EWC48299.1 - 0.089 12.6 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 L71 family Bromo_TP PF07524.8 EWC48299.1 - 0.14 11.8 0.1 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 Bromodomain associated MIF4G_like PF09088.6 EWC48300.1 - 2.9e-79 264.9 0.0 4.3e-79 264.4 0.0 1.3 1 0 0 1 1 1 1 MIF4G like MIF4G_like_2 PF09090.6 EWC48300.1 - 1.7e-50 171.5 0.0 2.5e-50 171.1 0.0 1.2 1 0 0 1 1 1 1 MIF4G like MIF4G PF02854.14 EWC48300.1 - 1.2e-05 24.8 0.0 3.4e-05 23.3 0.0 1.7 1 0 0 1 1 1 1 MIF4G domain adh_short PF00106.20 EWC48301.1 - 4.7e-23 81.9 0.0 7.8e-23 81.2 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EWC48301.1 - 3e-09 36.7 0.0 1.2e-08 34.8 0.0 1.8 1 1 0 1 1 1 1 KR domain Epimerase PF01370.16 EWC48301.1 - 1e-05 25.0 0.0 1.6e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 EWC48301.1 - 7.7e-05 21.7 0.0 0.00012 21.0 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.1 EWC48301.1 - 0.057 13.4 0.0 0.09 12.7 0.0 1.3 1 0 0 1 1 1 0 NADH(P)-binding Porin_3 PF01459.17 EWC48302.1 - 3.7e-71 239.6 0.5 4.3e-71 239.4 0.3 1.0 1 0 0 1 1 1 1 Eukaryotic porin Bac_surface_Ag PF01103.18 EWC48302.1 - 0.018 14.5 0.0 0.039 13.4 0.0 1.5 1 1 0 1 1 1 0 Surface antigen Pkinase PF00069.20 EWC48303.1 - 5.7e-63 212.4 0.0 7e-63 212.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC48303.1 - 1.6e-24 86.3 0.0 2e-24 86.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EWC48303.1 - 1.3e-06 27.6 0.0 3.1e-06 26.3 0.0 1.5 1 1 0 2 2 2 1 Kinase-like APH PF01636.18 EWC48303.1 - 0.00042 20.1 0.2 0.011 15.5 0.0 2.5 2 1 1 3 3 3 1 Phosphotransferase enzyme family F-box-like PF12937.2 EWC48304.1 - 7.2e-09 35.2 0.9 1.8e-08 33.9 0.6 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EWC48304.1 - 3.5e-08 32.8 0.7 8.3e-08 31.6 0.5 1.7 1 0 0 1 1 1 1 F-box domain F-box-like_2 PF13013.1 EWC48304.1 - 0.028 14.1 1.2 0.068 12.9 0.8 1.6 1 1 0 1 1 1 0 F-box-like domain Cohesin_load PF10345.4 EWC48305.1 - 3.8e-90 302.8 0.0 4.5e-90 302.6 0.0 1.0 1 0 0 1 1 1 1 Cohesin loading factor TPR_12 PF13424.1 EWC48305.1 - 0.39 10.6 11.7 0.81 9.6 0.0 5.3 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_6 PF13174.1 EWC48305.1 - 5.3 7.7 7.2 61 4.4 0.0 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat SOBP PF15279.1 EWC48306.1 - 0.0087 16.4 17.6 0.012 15.9 5.8 2.6 2 0 0 2 2 2 1 Sine oculis-binding protein Cep57_CLD_2 PF14197.1 EWC48306.1 - 0.016 15.1 1.2 0.016 15.1 0.9 2.4 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 5_nucleotid PF05761.9 EWC48306.1 - 0.1 11.0 0.3 0.18 10.2 0.2 1.3 1 0 0 1 1 1 0 5' nucleotidase family Filament PF00038.16 EWC48306.1 - 0.42 10.0 12.9 0.0098 15.3 3.3 2.2 2 1 0 2 2 2 0 Intermediate filament protein V_ATPase_I PF01496.14 EWC48306.1 - 0.43 8.3 1.5 0.78 7.5 1.1 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Mnd1 PF03962.10 EWC48306.1 - 2.2 7.8 9.6 0.23 11.1 1.7 2.5 2 0 0 2 2 2 0 Mnd1 family TPR_MLP1_2 PF07926.7 EWC48306.1 - 2.9 7.6 12.4 16 5.2 0.2 3.5 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein GTP_EFTU PF00009.22 EWC48307.1 - 1.6e-57 193.9 0.1 2.7e-57 193.2 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 EWC48307.1 - 1.1e-36 124.9 0.0 2.7e-36 123.6 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 EWC48307.1 - 9.9e-16 57.6 3.6 9.9e-16 57.6 2.5 2.1 3 0 0 3 3 3 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 EWC48307.1 - 0.00029 20.7 0.4 0.00099 19.0 0.3 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.1 EWC48307.1 - 0.0028 17.2 1.7 0.0028 17.2 1.2 2.1 2 0 0 2 2 2 1 Elongation factor Tu domain 4 DHBP_synthase PF00926.14 EWC48308.1 - 2.1e-81 271.7 0.2 2.4e-81 271.6 0.1 1.0 1 0 0 1 1 1 1 3,4-dihydroxy-2-butanone 4-phosphate synthase Drf_GBD PF06371.8 EWC48309.1 - 2.3e-05 23.8 0.0 0.00022 20.6 0.0 2.1 2 0 0 2 2 2 1 Diaphanous GTPase-binding Domain TFIIA PF03153.8 EWC48310.1 - 0.037 13.9 2.9 0.046 13.6 2.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Prothymosin PF03247.9 EWC48310.1 - 0.27 11.3 20.4 0.27 11.3 7.5 2.3 2 0 0 2 2 2 0 Prothymosin/parathymosin family DUF2457 PF10446.4 EWC48310.1 - 0.28 9.8 8.2 0.44 9.2 5.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) SDA1 PF05285.7 EWC48310.1 - 3.6 6.7 9.2 5.5 6.1 6.3 1.2 1 0 0 1 1 1 0 SDA1 HSP70 PF00012.15 EWC48311.1 - 6.8e-14 50.6 0.0 3.4e-12 45.0 0.0 2.0 2 0 0 2 2 2 2 Hsp70 protein Fungal_trans PF04082.13 EWC48312.1 - 8.8e-17 60.8 0.0 1.5e-16 60.0 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EWC48312.1 - 7e-07 29.0 11.0 1.4e-06 28.0 7.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain HTH_3 PF01381.17 EWC48312.1 - 0.13 12.1 0.0 0.26 11.1 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix SKG6 PF08693.5 EWC48313.1 - 0.019 14.2 0.0 0.038 13.3 0.0 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain CD99L2 PF12301.3 EWC48313.1 - 0.051 13.2 0.1 0.076 12.6 0.1 1.3 1 0 0 1 1 1 0 CD99 antigen like protein 2 HUN PF08729.5 EWC48314.1 - 4e-07 29.7 0.2 7.9e-07 28.8 0.1 1.4 1 0 0 1 1 1 1 HPC2 and ubinuclein domain MDM31_MDM32 PF08118.6 EWC48316.1 - 3.4e-176 586.6 0.0 8e-175 582.0 0.0 2.1 1 1 0 1 1 1 1 Yeast mitochondrial distribution and morphology (MDM) proteins Trypan_PARP PF05887.6 EWC48316.1 - 0.025 14.4 9.6 0.058 13.2 6.7 1.6 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) PLRV_ORF5 PF01690.12 EWC48316.1 - 1.9 7.5 9.9 3.2 6.7 6.9 1.3 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein ATP_synt_H PF05493.8 EWC48317.1 - 0.12 12.4 0.1 0.18 11.8 0.1 1.3 1 0 0 1 1 1 0 ATP synthase subunit H 4HBT PF03061.17 EWC48318.1 - 4.2e-12 46.0 0.2 5.6e-12 45.6 0.1 1.2 1 0 0 1 1 1 1 Thioesterase superfamily DUF4442 PF14539.1 EWC48318.1 - 0.017 15.0 0.0 0.023 14.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4442) 4HBT_3 PF13622.1 EWC48318.1 - 0.042 13.5 0.0 0.056 13.1 0.0 1.3 1 0 0 1 1 1 0 Thioesterase-like superfamily 4HBT_2 PF13279.1 EWC48318.1 - 0.1 13.0 0.0 0.14 12.6 0.0 1.3 1 0 0 1 1 1 0 Thioesterase-like superfamily Pkinase PF00069.20 EWC48319.1 - 1.2e-62 211.4 0.0 1.8e-62 210.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC48319.1 - 4.8e-26 91.3 0.0 6.9e-26 90.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EWC48319.1 - 0.0099 14.8 0.0 0.017 14.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 EWC48319.1 - 0.031 13.3 0.0 0.059 12.4 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 EWC48319.1 - 0.049 13.3 0.0 2.5 7.7 0.0 2.6 2 1 1 3 3 3 0 Phosphotransferase enzyme family QH-AmDH_gamma PF08992.6 EWC48320.1 - 0.12 12.1 0.3 0.44 10.3 0.0 2.0 2 0 0 2 2 2 0 Quinohemoprotein amine dehydrogenase, gamma subunit Ank_2 PF12796.2 EWC48321.1 - 5e-27 94.0 0.0 2.3e-05 24.6 0.0 6.7 3 1 0 6 6 6 6 Ankyrin repeats (3 copies) Ank_5 PF13857.1 EWC48321.1 - 7.2e-18 64.2 0.0 0.002 18.3 0.0 7.0 7 0 0 7 7 7 4 Ankyrin repeats (many copies) Ank_4 PF13637.1 EWC48321.1 - 3.8e-12 46.3 0.6 0.32 11.5 0.0 7.1 6 1 1 7 7 7 4 Ankyrin repeats (many copies) Ank PF00023.25 EWC48321.1 - 2.5e-10 39.6 1.0 0.95 9.4 0.0 6.6 8 0 0 8 8 8 4 Ankyrin repeat Ank_3 PF13606.1 EWC48321.1 - 3.5e-09 36.0 0.0 0.86 10.0 0.0 6.9 7 0 0 7 7 7 2 Ankyrin repeat WSC PF01822.14 EWC48322.1 - 4e-11 42.6 13.9 1.4e-07 31.3 4.2 2.7 2 0 0 2 2 2 2 WSC domain Mito_carr PF00153.22 EWC48323.1 - 7.8e-68 224.2 5.5 8.9e-24 83.0 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein P16-Arc PF04699.9 EWC48324.1 - 8.5e-51 171.9 0.0 9.6e-51 171.7 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) Acetyltransf_4 PF13420.1 EWC48324.1 - 0.091 12.6 0.0 0.14 12.1 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Ras PF00071.17 EWC48325.1 - 3.3e-56 189.1 0.0 4e-56 188.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EWC48325.1 - 5.7e-20 71.9 0.0 1.2e-19 70.9 0.0 1.5 2 0 0 2 2 2 1 Miro-like protein Arf PF00025.16 EWC48325.1 - 1.1e-13 50.7 0.0 2.8e-13 49.4 0.0 1.5 2 0 0 2 2 2 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 EWC48325.1 - 1.4e-05 24.6 0.0 3e-05 23.5 0.0 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 EWC48325.1 - 1.4e-05 24.3 0.0 2.2e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 EWC48325.1 - 0.00097 19.0 0.0 0.0021 18.0 0.0 1.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_16 PF13191.1 EWC48325.1 - 0.0057 16.6 0.0 0.007 16.3 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 EWC48325.1 - 0.13 12.4 0.0 0.34 11.0 0.0 1.7 2 1 0 2 2 2 0 AAA domain Fungal_trans PF04082.13 EWC48327.1 - 5.3e-25 87.7 0.0 9.9e-25 86.8 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EWC48327.1 - 4.1e-09 36.1 12.8 7.4e-09 35.3 8.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Hamartin PF04388.7 EWC48329.1 - 0.18 10.4 5.8 0.23 10.0 4.0 1.1 1 0 0 1 1 1 0 Hamartin protein HpaP PF09483.5 EWC48329.1 - 1.2 9.0 9.0 0.63 9.9 4.8 1.5 1 1 1 2 2 2 0 Type III secretion protein (HpaP) zf-BED PF02892.10 EWC48330.1 - 0.0035 17.0 2.0 0.0063 16.2 1.4 1.4 1 0 0 1 1 1 1 BED zinc finger zf-H2C2_2 PF13465.1 EWC48330.1 - 0.046 14.0 2.4 3.6 8.0 0.3 2.4 2 0 0 2 2 2 0 Zinc-finger double domain zf-C2H2 PF00096.21 EWC48330.1 - 0.051 13.9 4.9 0.11 12.8 3.4 1.6 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EWC48330.1 - 0.062 13.6 3.6 0.12 12.7 2.5 1.5 1 0 0 1 1 1 0 C2H2-type zinc finger Lactonase PF10282.4 EWC48331.1 - 0.023 13.8 0.0 0.47 9.4 0.0 2.6 2 1 0 3 3 3 0 Lactonase, 7-bladed beta-propeller DUF3602 PF12223.3 EWC48332.1 - 2.3e-10 40.6 8.7 0.00062 20.0 0.7 3.3 1 1 2 3 3 3 3 Protein of unknown function (DUF3602) Chalcone PF02431.10 EWC48334.1 - 8e-45 152.6 0.0 3.1e-44 150.7 0.0 1.8 1 1 0 1 1 1 1 Chalcone-flavanone isomerase LANC_like PF05147.8 EWC48335.1 - 1.7e-25 89.3 0.0 2.2e-25 88.9 0.0 1.3 1 1 0 1 1 1 1 Lanthionine synthetase C-like protein WD40 PF00400.27 EWC48336.1 - 3.1e-13 49.0 8.4 0.18 11.7 0.0 8.7 9 0 0 9 9 8 4 WD domain, G-beta repeat AAA_16 PF13191.1 EWC48336.1 - 3.2e-07 30.5 0.1 1.4e-06 28.4 0.1 2.1 1 1 0 1 1 1 1 AAA ATPase domain NACHT PF05729.7 EWC48336.1 - 4.4e-07 29.6 0.0 9.8e-07 28.5 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.1 EWC48336.1 - 0.00035 20.7 0.0 0.00095 19.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA PF00004.24 EWC48336.1 - 0.0022 18.2 0.0 0.072 13.3 0.0 2.7 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) PQQ_2 PF13360.1 EWC48336.1 - 0.0044 16.5 0.0 0.045 13.1 0.0 2.3 1 1 0 2 2 2 1 PQQ-like domain RNA_helicase PF00910.17 EWC48336.1 - 0.018 15.2 0.0 0.16 12.1 0.0 2.7 2 0 0 2 2 2 0 RNA helicase APS_kinase PF01583.15 EWC48336.1 - 0.029 14.0 0.0 0.054 13.1 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase TrwB_AAD_bind PF10412.4 EWC48336.1 - 0.032 12.8 0.3 0.2 10.2 0.0 2.0 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain MobB PF03205.9 EWC48336.1 - 0.1 12.2 0.6 0.34 10.6 0.0 2.1 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_30 PF13604.1 EWC48336.1 - 0.13 11.7 0.1 0.27 10.7 0.1 1.4 1 0 0 1 1 1 0 AAA domain PD40 PF07676.7 EWC48336.1 - 0.18 11.5 2.8 42 3.9 0.0 5.0 7 0 0 7 7 7 0 WD40-like Beta Propeller Repeat DUF1513 PF07433.6 EWC48336.1 - 0.24 10.2 0.1 14 4.4 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1513) Glutaredoxin PF00462.19 EWC48337.1 - 2.2e-18 66.0 0.1 3.1e-18 65.5 0.1 1.2 1 0 0 1 1 1 1 Glutaredoxin GST_N_3 PF13417.1 EWC48337.1 - 4.2e-06 26.8 0.0 5.9e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain DUF836 PF05768.9 EWC48337.1 - 0.0017 18.5 0.1 0.0022 18.1 0.0 1.4 1 1 0 1 1 1 1 Glutaredoxin-like domain (DUF836) GST_N_2 PF13409.1 EWC48337.1 - 0.0023 17.9 0.0 0.003 17.5 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain DSBA PF01323.15 EWC48337.1 - 0.0066 16.0 0.0 0.32 10.5 0.0 2.1 1 1 1 2 2 2 1 DSBA-like thioredoxin domain AhpC-TSA PF00578.16 EWC48337.1 - 0.037 13.7 0.0 0.048 13.3 0.0 1.2 1 0 0 1 1 1 0 AhpC/TSA family Thioredoxin_2 PF13098.1 EWC48337.1 - 0.045 13.9 0.1 0.058 13.5 0.1 1.3 1 1 0 1 1 1 0 Thioredoxin-like domain DUF953 PF06110.6 EWC48337.1 - 0.11 11.9 0.1 1.1 8.6 0.0 2.0 1 1 1 2 2 2 0 Eukaryotic protein of unknown function (DUF953) Ctr PF04145.10 EWC48340.1 - 1.3e-37 128.9 0.4 1.9e-37 128.5 0.3 1.2 1 0 0 1 1 1 1 Ctr copper transporter family Dynactin_p62 PF05502.8 EWC48341.1 - 1.3e-103 347.3 17.1 3.2e-51 174.6 10.2 2.1 1 1 1 2 2 2 2 Dynactin p62 family Glyco_transf_22 PF03901.12 EWC48341.1 - 0.39 9.6 1.7 2.8 6.8 0.1 2.1 1 1 1 2 2 2 0 Alg9-like mannosyltransferase family BAG PF02179.11 EWC48343.1 - 3.5e-14 52.6 0.2 5.7e-14 51.9 0.1 1.3 1 0 0 1 1 1 1 BAG domain ubiquitin PF00240.18 EWC48343.1 - 9.7e-06 24.8 0.0 2.7e-05 23.4 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 EWC48343.1 - 0.021 14.5 0.0 0.06 13.0 0.0 1.7 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Rossmann-like PF10727.4 EWC48344.1 - 0.049 13.3 1.4 8.3 6.1 0.2 2.5 2 0 0 2 2 2 0 Rossmann-like domain SKG6 PF08693.5 EWC48344.1 - 5.1 6.4 5.0 4.3 6.7 1.6 2.2 2 0 0 2 2 2 0 Transmembrane alpha-helix domain HMG_box PF00505.14 EWC48345.1 - 1.2e-17 63.9 4.3 3.7e-09 36.7 0.1 3.2 3 0 0 3 3 3 2 HMG (high mobility group) box HMG_box_2 PF09011.5 EWC48345.1 - 2.1e-15 56.8 7.2 3.4e-08 33.7 0.7 3.1 2 1 0 2 2 2 2 HMG-box domain HC2 PF07382.6 EWC48345.1 - 1.8e-08 34.4 55.8 1.8e-08 34.4 38.7 1.9 2 0 0 2 2 2 1 Histone H1-like nucleoprotein HC2 ASFV_J13L PF05568.6 EWC48345.1 - 9.2 5.7 14.6 17 4.8 9.7 1.7 1 1 1 2 2 2 0 African swine fever virus J13L protein Med16 PF11635.3 EWC48346.1 - 2.7e-117 392.7 0.3 3.1e-117 392.4 0.2 1.0 1 0 0 1 1 1 1 Mediator complex subunit 16 ESCRT-II PF05871.7 EWC48347.1 - 4.9e-48 162.5 0.1 6e-48 162.2 0.0 1.1 1 0 0 1 1 1 1 ESCRT-II complex subunit DUF927 PF06048.6 EWC48347.1 - 0.093 11.9 0.1 0.3 10.3 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF927) PTCB-BRCT PF12738.2 EWC48348.1 - 3.9e-26 90.6 0.0 8.1e-17 60.8 0.0 5.2 5 0 0 5 5 5 4 twin BRCT domain BRCT PF00533.21 EWC48348.1 - 4.5e-25 87.5 0.0 2e-05 24.6 0.0 6.5 6 1 0 6 6 6 5 BRCA1 C Terminus (BRCT) domain ATP-synt_10 PF05176.9 EWC48349.1 - 1.1e-71 241.0 0.0 2.4e-71 239.9 0.0 1.5 1 1 0 1 1 1 1 ATP10 protein RRM_1 PF00076.17 EWC48350.1 - 9.5e-19 66.8 0.0 4.4e-09 35.8 0.0 3.1 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EWC48350.1 - 5.3e-15 55.1 0.1 3.1e-08 33.4 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EWC48350.1 - 1.9e-08 34.0 0.0 4.1e-05 23.3 0.0 2.6 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Peptidase_S49_N PF08496.5 EWC48350.1 - 0.12 12.2 5.7 0.41 10.4 0.2 2.6 3 0 0 3 3 3 0 Peptidase family S49 N-terminal Ammonium_transp PF00909.16 EWC48351.1 - 3.7e-116 387.8 21.6 4.2e-116 387.7 15.0 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family Surf_Ag_VNR PF07244.10 EWC48352.1 - 0.16 12.3 0.0 0.31 11.4 0.0 1.4 1 0 0 1 1 1 0 Surface antigen variable number repeat Pkinase PF00069.20 EWC48353.1 - 4.2e-70 235.8 0.0 9.5e-70 234.7 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC48353.1 - 6.2e-41 140.1 0.0 1.1e-40 139.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EWC48353.1 - 9.6e-09 34.5 0.0 1.9e-08 33.6 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 EWC48353.1 - 0.00035 20.3 0.0 0.00097 18.9 0.0 1.7 1 0 0 1 1 1 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 EWC48353.1 - 0.002 16.9 0.0 0.0037 16.1 0.0 1.3 1 0 0 1 1 1 1 Seadornavirus VP7 CBFD_NFYB_HMF PF00808.18 EWC48354.1 - 2.2e-12 46.8 0.0 5.8e-12 45.4 0.0 1.8 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 EWC48354.1 - 1.4e-05 25.1 0.0 7.2e-05 22.8 0.0 2.0 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 FLO_LFY PF01698.11 EWC48354.1 - 4.9 5.8 6.6 6.3 5.5 4.6 1.3 1 0 0 1 1 1 0 Floricaula / Leafy protein Ribosomal_L29 PF00831.18 EWC48355.1 - 7.7e-19 67.1 0.8 7.7e-19 67.1 0.5 2.2 2 1 1 3 3 3 1 Ribosomal L29 protein Snapin_Pallidin PF14712.1 EWC48355.1 - 0.0092 16.2 1.3 0.0092 16.2 0.9 1.8 1 1 1 2 2 2 1 Snapin/Pallidin LktC PF06261.6 EWC48355.1 - 0.074 12.7 0.1 0.085 12.5 0.1 1.3 1 0 0 1 1 1 0 Actinobacillus actinomycetemcomitans leukotoxin activator LktC DUF3886 PF13025.1 EWC48355.1 - 0.19 11.7 7.2 0.99 9.4 1.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3886) HALZ PF02183.13 EWC48355.1 - 0.54 10.0 5.6 4.5 7.0 0.3 2.3 2 0 0 2 2 2 0 Homeobox associated leucine zipper Cortex-I_coil PF09304.5 EWC48355.1 - 2.2 8.3 7.3 0.49 10.4 0.9 2.2 1 1 0 2 2 2 0 Cortexillin I, coiled coil V-SNARE_C PF12352.3 EWC48356.1 - 8.3e-12 44.9 0.2 8.3e-12 44.9 0.1 2.5 3 0 0 3 3 3 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.8 EWC48356.1 - 0.039 13.6 3.9 2.4 7.9 0.0 3.2 3 1 0 3 3 3 0 Sec20 Uds1 PF15456.1 EWC48356.1 - 0.22 11.4 9.5 0.062 13.2 2.8 2.4 1 1 0 2 2 2 0 Up-regulated During Septation Allexi_40kDa PF05549.6 EWC48356.1 - 0.84 8.8 6.6 0.44 9.7 1.5 2.0 1 1 1 2 2 2 0 Allexivirus 40kDa protein FliT PF05400.8 EWC48356.1 - 6 7.3 8.5 3.5 8.1 2.6 2.5 2 1 1 3 3 3 0 Flagellar protein FliT SLD3 PF08639.5 EWC48357.1 - 1.1e-68 232.1 12.4 1.1e-68 232.1 8.6 2.1 2 0 0 2 2 2 1 DNA replication regulator SLD3 Period_C PF12114.3 EWC48358.1 - 3.6 7.1 9.9 4.2 6.9 6.9 1.2 1 0 0 1 1 1 0 Period protein 2/3C-terminal region Abhydrolase_6 PF12697.2 EWC48360.1 - 1e-30 107.3 0.5 1.3e-30 106.9 0.3 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EWC48360.1 - 1.1e-05 25.2 0.0 5.3e-05 22.9 0.0 2.2 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EWC48360.1 - 0.00053 19.6 0.0 0.0015 18.1 0.0 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Chlorophyllase PF07224.6 EWC48360.1 - 0.035 12.9 0.0 0.053 12.2 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase Chlorophyllase2 PF12740.2 EWC48360.1 - 0.15 10.8 0.0 0.26 10.1 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase enzyme DUF3808 PF10300.4 EWC48361.1 - 7.9e-126 420.3 2.2 9.5e-126 420.0 1.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) TPR_16 PF13432.1 EWC48361.1 - 7.4e-05 23.3 3.1 1.2 9.8 0.5 4.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.1 EWC48361.1 - 0.002 17.7 3.3 0.1 12.2 0.4 3.2 3 0 0 3 3 3 2 TPR repeat DSS1_SEM1 PF05160.8 EWC48362.1 - 8.8e-23 79.8 15.8 1.2e-22 79.4 11.0 1.2 1 0 0 1 1 1 1 DSS1/SEM1 family Cwf_Cwc_15 PF04889.7 EWC48362.1 - 0.4 10.3 8.8 0.43 10.2 6.1 1.0 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CDC27 PF09507.5 EWC48362.1 - 4.5 6.3 10.7 4.9 6.2 7.4 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 PGK PF00162.14 EWC48363.1 - 1.3e-148 494.7 0.2 1.4e-148 494.5 0.2 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase AhpC-TSA_2 PF13911.1 EWC48364.1 - 1.4e-11 44.3 0.0 2e-11 43.8 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme AhpC-TSA PF00578.16 EWC48364.1 - 5.8e-05 22.7 0.0 8.9e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 EWC48364.1 - 0.001 18.6 0.0 0.12 11.9 0.0 2.1 1 1 1 2 2 2 2 Redoxin DNA_pol_B_palm PF14792.1 EWC48365.1 - 1.4e-28 99.1 0.0 2.8e-28 98.2 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase beta palm DNA_pol_B_thumb PF14791.1 EWC48365.1 - 5.5e-22 77.2 0.2 1.8e-21 75.5 0.0 2.0 2 0 0 2 2 2 1 DNA polymerase beta thumb HHH_8 PF14716.1 EWC48365.1 - 3.7e-12 46.2 0.0 7.6e-12 45.2 0.0 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix domain DNA_pol_lambd_f PF10391.4 EWC48365.1 - 3.7e-11 42.4 0.0 9.4e-11 41.0 0.0 1.7 1 0 0 1 1 1 1 Fingers domain of DNA polymerase lambda BRCT PF00533.21 EWC48365.1 - 4.4e-06 26.7 0.0 1.1e-05 25.4 0.0 1.6 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain HHH PF00633.18 EWC48365.1 - 0.0046 16.5 0.0 0.012 15.2 0.0 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix motif NTP_transf_2 PF01909.18 EWC48365.1 - 0.016 15.4 0.0 0.032 14.5 0.0 1.4 1 0 0 1 1 1 0 Nucleotidyltransferase domain HHH_5 PF14520.1 EWC48365.1 - 0.021 14.9 0.3 0.62 10.2 0.2 2.6 1 1 0 1 1 1 0 Helix-hairpin-helix domain PTCB-BRCT PF12738.2 EWC48365.1 - 0.092 12.6 0.0 0.25 11.2 0.0 1.7 1 0 0 1 1 1 0 twin BRCT domain Dicty_REP PF05086.7 EWC48365.1 - 0.28 8.8 1.1 0.39 8.4 0.8 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF4349 PF14257.1 EWC48366.1 - 0.004 16.4 1.7 0.0042 16.3 1.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4349) SNF2_N PF00176.18 EWC48367.1 - 8.6e-70 234.8 2.8 1.4e-69 234.1 1.9 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Chromo PF00385.19 EWC48367.1 - 9e-22 76.5 0.4 3.9e-12 45.6 0.0 3.0 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Helicase_C PF00271.26 EWC48367.1 - 1.5e-15 56.7 0.0 3.8e-15 55.5 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4208 PF13907.1 EWC48367.1 - 1e-08 35.3 0.6 1e-08 35.3 0.4 2.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4208) AAA_22 PF13401.1 EWC48367.1 - 0.037 14.1 0.0 0.11 12.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain SOBP PF15279.1 EWC48367.1 - 5.3 7.3 19.6 0.042 14.2 1.2 3.2 3 0 0 3 3 3 0 Sine oculis-binding protein Glyco_hydro_61 PF03443.9 EWC48368.1 - 1.1e-42 146.3 2.5 1.9e-42 145.5 0.0 2.1 2 0 0 2 2 2 1 Glycosyl hydrolase family 61 CBM_1 PF00734.13 EWC48368.1 - 1.6e-12 46.8 11.4 4.2e-12 45.5 7.9 1.8 1 0 0 1 1 1 1 Fungal cellulose binding domain Med3 PF11593.3 EWC48368.1 - 3.5 6.7 27.4 4.5 6.4 19.0 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal MAP65_ASE1 PF03999.7 EWC48368.1 - 8.9 4.7 11.8 12 4.3 8.2 1.0 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) ATP_bind_1 PF03029.12 EWC48369.1 - 1.7e-80 270.0 0.0 1.9e-80 269.8 0.0 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_17 PF13207.1 EWC48369.1 - 1.4e-05 25.8 2.1 0.0002 22.1 1.5 2.5 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 EWC48369.1 - 9.2e-05 22.5 0.6 0.0053 16.7 0.0 2.4 1 1 0 2 2 2 1 AAA ATPase domain AAA_14 PF13173.1 EWC48369.1 - 0.00083 19.2 0.0 0.0018 18.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA PF00004.24 EWC48369.1 - 0.0027 17.9 0.0 0.0051 17.0 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) NACHT PF05729.7 EWC48369.1 - 0.0034 17.0 0.1 0.0098 15.5 0.1 1.9 1 1 0 1 1 1 1 NACHT domain MobB PF03205.9 EWC48369.1 - 0.0036 17.0 0.0 0.0074 16.0 0.0 1.5 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_18 PF13238.1 EWC48369.1 - 0.0055 17.0 0.4 0.068 13.4 0.0 2.3 2 1 0 2 2 2 1 AAA domain RNA_helicase PF00910.17 EWC48369.1 - 0.0058 16.7 0.0 0.017 15.2 0.0 1.8 2 0 0 2 2 2 1 RNA helicase AAA_31 PF13614.1 EWC48369.1 - 0.0069 16.3 0.0 0.015 15.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain T2SE PF00437.15 EWC48369.1 - 0.012 14.5 0.0 0.018 13.9 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_22 PF13401.1 EWC48369.1 - 0.014 15.5 0.0 0.031 14.3 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.1 EWC48369.1 - 0.016 14.9 0.0 0.029 14.1 0.0 1.3 1 0 0 1 1 1 0 Part of AAA domain AAA_24 PF13479.1 EWC48369.1 - 0.024 14.2 0.0 0.044 13.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain Arch_ATPase PF01637.13 EWC48369.1 - 0.027 14.1 0.0 0.062 12.9 0.0 1.6 2 0 0 2 2 2 0 Archaeal ATPase Miro PF08477.8 EWC48369.1 - 0.032 14.7 0.0 2.3 8.7 0.0 2.5 2 0 0 2 2 2 0 Miro-like protein SRP54 PF00448.17 EWC48369.1 - 0.035 13.5 0.0 0.059 12.7 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain G-alpha PF00503.15 EWC48369.1 - 0.038 12.6 0.2 1.1 7.8 0.0 2.1 2 0 0 2 2 2 0 G-protein alpha subunit cobW PF02492.14 EWC48369.1 - 0.053 12.9 0.1 9.6 5.6 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain CbiA PF01656.18 EWC48369.1 - 0.063 12.6 0.0 0.11 11.9 0.0 1.5 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain PduV-EutP PF10662.4 EWC48369.1 - 0.07 12.6 0.0 0.7 9.3 0.0 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_29 PF13555.1 EWC48369.1 - 0.071 12.6 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_33 PF13671.1 EWC48369.1 - 0.075 12.9 0.0 0.2 11.5 0.0 1.7 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.22 EWC48369.1 - 0.095 12.9 0.0 0.23 11.7 0.0 1.6 1 0 0 1 1 1 0 ABC transporter Viral_helicase1 PF01443.13 EWC48369.1 - 0.12 11.9 0.0 0.22 10.9 0.0 1.5 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_5 PF07728.9 EWC48369.1 - 0.15 11.7 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) KaiC PF06745.8 EWC48369.1 - 0.16 11.0 0.0 0.28 10.2 0.0 1.3 1 0 0 1 1 1 0 KaiC Mg_chelatase PF01078.16 EWC48369.1 - 0.16 11.0 0.0 0.52 9.4 0.0 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI SIR2 PF02146.12 EWC48370.1 - 5e-26 91.5 0.0 1.5e-25 89.9 0.0 1.8 1 1 0 1 1 1 1 Sir2 family Totivirus_coat PF05518.6 EWC48370.1 - 1.4 6.6 7.0 11 3.6 3.3 2.1 2 0 0 2 2 2 0 Totivirus coat protein NMO PF03060.10 EWC48371.1 - 3.2e-62 210.6 0.2 4e-62 210.2 0.2 1.1 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.20 EWC48371.1 - 1.1e-10 40.9 0.0 0.0001 21.3 0.0 2.1 1 1 1 2 2 2 2 IMP dehydrogenase / GMP reductase domain DUF1902 PF08972.6 EWC48371.1 - 0.001 18.5 0.1 0.0034 16.9 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF1902) TMP-TENI PF02581.12 EWC48371.1 - 0.0035 16.4 0.1 0.066 12.3 0.0 2.3 2 0 0 2 2 2 1 Thiamine monophosphate synthase/TENI FMN_dh PF01070.13 EWC48371.1 - 0.005 15.7 0.1 0.011 14.5 0.1 1.6 1 0 0 1 1 1 1 FMN-dependent dehydrogenase NanE PF04131.9 EWC48371.1 - 0.0063 15.4 0.1 0.01 14.8 0.0 1.3 1 0 0 1 1 1 1 Putative N-acetylmannosamine-6-phosphate epimerase His_biosynth PF00977.16 EWC48371.1 - 0.018 14.2 0.1 0.045 13.0 0.1 1.7 2 0 0 2 2 2 0 Histidine biosynthesis protein Ank PF00023.25 EWC48372.1 - 5.7e-12 44.8 1.6 2.7e-05 23.7 0.1 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.1 EWC48372.1 - 2.6e-11 43.6 0.3 5.9e-06 26.6 0.1 2.1 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.2 EWC48372.1 - 3.4e-10 40.1 0.3 6.2e-10 39.2 0.2 1.4 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.1 EWC48372.1 - 6.1e-08 32.1 0.3 0.086 13.1 0.0 3.1 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.1 EWC48372.1 - 4.4e-07 29.9 6.8 0.00092 19.3 0.3 2.8 1 1 2 3 3 3 3 Ankyrin repeats (many copies) zf-RING_2 PF13639.1 EWC48372.1 - 0.071 12.9 0.1 0.1 12.4 0.1 1.3 1 0 0 1 1 1 0 Ring finger domain ABC_tran PF00005.22 EWC48374.1 - 9.8e-36 123.0 0.0 2.3e-17 63.6 0.0 2.5 2 0 0 2 2 2 2 ABC transporter RLI PF04068.10 EWC48374.1 - 1.5e-13 50.0 4.6 1.5e-13 50.0 3.2 2.0 2 0 0 2 2 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI AAA_21 PF13304.1 EWC48374.1 - 4.5e-13 49.8 8.0 0.0097 15.8 0.0 4.4 2 2 2 4 4 4 4 AAA domain SMC_N PF02463.14 EWC48374.1 - 1.1e-11 44.3 2.2 0.00025 20.3 0.0 3.8 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_15 PF13175.1 EWC48374.1 - 7.9e-08 31.7 0.1 1.4 7.8 0.0 4.2 4 0 0 4 4 4 2 AAA ATPase domain AAA_22 PF13401.1 EWC48374.1 - 3.7e-07 30.3 0.1 0.008 16.3 0.0 3.3 2 1 0 2 2 2 2 AAA domain AAA_17 PF13207.1 EWC48374.1 - 4.7e-07 30.6 1.1 0.043 14.6 0.2 3.4 2 2 0 2 2 2 2 AAA domain AAA PF00004.24 EWC48374.1 - 3.1e-06 27.4 0.1 0.049 13.8 0.0 3.0 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.1 EWC48374.1 - 5e-06 26.8 2.2 0.059 13.6 0.5 3.3 2 2 0 2 2 2 2 AAA domain Fer4 PF00037.22 EWC48374.1 - 7.5e-05 22.1 2.5 7.5e-05 22.1 1.8 2.4 2 0 0 2 2 2 1 4Fe-4S binding domain DUF258 PF03193.11 EWC48374.1 - 9.1e-05 21.7 1.1 0.26 10.4 0.0 3.1 3 0 0 3 3 3 2 Protein of unknown function, DUF258 AAA_29 PF13555.1 EWC48374.1 - 0.00015 21.2 0.2 0.14 11.7 0.0 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain Miro PF08477.8 EWC48374.1 - 0.00066 20.1 0.1 1.1 9.7 0.0 3.5 3 0 0 3 3 3 1 Miro-like protein UPF0079 PF02367.12 EWC48374.1 - 0.00086 18.9 0.0 0.082 12.5 0.0 2.6 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 Fer4_21 PF14697.1 EWC48374.1 - 0.0011 18.7 11.3 0.0021 17.8 7.8 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain RNA_helicase PF00910.17 EWC48374.1 - 0.0014 18.8 0.1 1.4 9.1 0.0 2.9 2 0 0 2 2 2 1 RNA helicase AAA_33 PF13671.1 EWC48374.1 - 0.0014 18.5 0.0 0.67 9.8 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 EWC48374.1 - 0.0018 18.3 0.1 1.4 8.8 0.0 2.6 2 1 0 2 2 2 1 AAA ATPase domain VirE PF05272.6 EWC48374.1 - 0.0019 17.6 0.1 1.4 8.3 0.0 2.6 2 0 0 2 2 2 1 Virulence-associated protein E SRP54 PF00448.17 EWC48374.1 - 0.0021 17.5 1.8 0.21 11.0 0.0 2.3 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_25 PF13481.1 EWC48374.1 - 0.0028 17.0 0.0 1.5 8.1 0.0 2.7 2 0 0 2 2 2 1 AAA domain NACHT PF05729.7 EWC48374.1 - 0.0053 16.4 2.1 0.84 9.2 0.0 2.8 3 0 0 3 3 3 1 NACHT domain MobB PF03205.9 EWC48374.1 - 0.0063 16.2 1.5 1.6 8.4 0.1 2.8 3 0 0 3 3 2 1 Molybdopterin guanine dinucleotide synthesis protein B Rad17 PF03215.10 EWC48374.1 - 0.014 14.1 0.0 0.072 11.7 0.0 1.9 2 0 0 2 2 2 0 Rad17 cell cycle checkpoint protein AAA_28 PF13521.1 EWC48374.1 - 0.015 15.2 0.0 5.4 6.9 0.0 2.7 3 0 0 3 3 2 0 AAA domain Fer4_10 PF13237.1 EWC48374.1 - 0.016 14.9 1.8 0.016 14.9 1.2 2.2 1 1 1 2 2 2 0 4Fe-4S dicluster domain AAA_13 PF13166.1 EWC48374.1 - 0.024 13.1 0.0 0.024 13.1 0.0 3.2 4 1 1 5 5 4 0 AAA domain NB-ARC PF00931.17 EWC48374.1 - 0.027 13.3 0.0 1.3 7.8 0.0 2.2 2 0 0 2 2 2 0 NB-ARC domain Thymidylate_kin PF02223.12 EWC48374.1 - 0.057 12.7 1.3 6.4 6.1 0.0 3.0 4 0 0 4 4 2 0 Thymidylate kinase Fer4_16 PF13484.1 EWC48374.1 - 0.058 14.1 0.1 0.058 14.1 0.1 2.6 2 0 0 2 2 2 0 4Fe-4S double cluster binding domain AAA_5 PF07728.9 EWC48374.1 - 0.087 12.5 0.2 6.4 6.4 0.0 2.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_24 PF13479.1 EWC48374.1 - 0.089 12.3 0.5 1.6 8.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.4 EWC48374.1 - 0.091 12.2 1.5 0.18 11.2 0.0 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_30 PF13604.1 EWC48374.1 - 0.099 12.2 0.2 11 5.4 0.0 3.0 3 0 0 3 3 3 0 AAA domain DUF359 PF04019.7 EWC48374.1 - 0.1 11.9 0.2 0.25 10.7 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF359) Fer4_6 PF12837.2 EWC48374.1 - 0.13 12.1 11.5 0.031 14.1 2.0 2.4 2 0 0 2 2 2 0 4Fe-4S binding domain AAA_14 PF13173.1 EWC48374.1 - 0.18 11.7 3.0 28 4.6 0.1 3.7 2 2 1 3 3 3 0 AAA domain Fer4_8 PF13183.1 EWC48374.1 - 0.29 11.1 9.4 0.59 10.2 1.4 1.8 1 1 1 2 2 2 0 4Fe-4S dicluster domain AAA_23 PF13476.1 EWC48374.1 - 0.32 11.2 0.1 0.32 11.2 0.1 2.9 2 1 0 2 2 2 0 AAA domain Fer4_2 PF12797.2 EWC48374.1 - 0.47 10.4 12.6 0.48 10.4 1.9 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_9 PF13187.1 EWC48374.1 - 0.73 10.1 12.9 0.087 13.1 1.5 2.0 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_7 PF12838.2 EWC48374.1 - 0.84 10.0 13.1 0.047 14.0 1.3 2.2 1 1 2 3 3 3 0 4Fe-4S dicluster domain FF PF01846.14 EWC48375.1 - 8.6e-51 169.6 19.2 4.8e-13 48.8 0.2 6.8 6 0 0 6 6 6 6 FF domain WW PF00397.21 EWC48375.1 - 5.6e-14 51.6 9.3 8.6e-08 31.9 0.2 2.8 2 0 0 2 2 2 2 WW domain PRP38_assoc PF12871.2 EWC48375.1 - 0.019 15.4 39.9 0.019 15.4 27.6 7.8 4 2 3 7 7 7 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Trs65 PF12735.2 EWC48376.1 - 8.6e-58 196.0 0.5 1.4e-57 195.3 0.1 1.5 2 0 0 2 2 2 1 TRAPP trafficking subunit Trs65 Mpv17_PMP22 PF04117.7 EWC48376.1 - 1.6e-22 78.9 0.4 3.5e-22 77.7 0.3 1.6 1 0 0 1 1 1 1 Mpv17 / PMP22 family S-AdoMet_synt_C PF02773.11 EWC48377.1 - 7.5e-75 249.2 0.2 1.3e-74 248.4 0.1 1.4 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.11 EWC48377.1 - 2.3e-46 156.6 0.0 4.2e-46 155.7 0.0 1.4 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.15 EWC48377.1 - 2.4e-44 149.6 0.2 5.5e-44 148.4 0.1 1.6 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, N-terminal domain AdoMet_Synthase PF01941.14 EWC48377.1 - 0.076 11.5 0.2 0.35 9.3 0.1 1.9 1 1 0 2 2 2 0 S-adenosylmethionine synthetase (AdoMet synthetase) DUF2312 PF10073.4 EWC48377.1 - 0.1 11.9 0.1 0.24 10.8 0.1 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2312) Nup160 PF11715.3 EWC48379.1 - 4.4e-72 242.9 0.7 5.7e-72 242.5 0.5 1.1 1 0 0 1 1 1 1 Nucleoporin Nup120/160 ATP_transf PF09830.4 EWC48380.1 - 1.7e-15 56.5 0.0 2.5e-15 56.0 0.0 1.3 1 0 0 1 1 1 1 ATP adenylyltransferase CorA PF01544.13 EWC48381.1 - 2.3e-06 26.8 7.5 7.1e-06 25.2 5.2 1.8 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein CPL PF08144.6 EWC48382.1 - 2.9e-22 79.1 1.4 4.5e-21 75.2 0.1 3.1 2 1 1 3 3 3 1 CPL (NUC119) domain DUF2890 PF11081.3 EWC48382.1 - 0.95 9.4 11.0 2 8.4 7.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) TFIIF_alpha PF05793.7 EWC48382.1 - 2.7 6.2 23.4 4.4 5.5 16.2 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Rad51 PF08423.6 EWC48383.1 - 5.2e-138 458.1 0.0 7.2e-138 457.6 0.0 1.2 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.1 EWC48383.1 - 1.4e-14 53.9 0.0 2e-14 53.4 0.0 1.2 1 0 0 1 1 1 1 AAA domain HHH_5 PF14520.1 EWC48383.1 - 6.4e-11 42.2 0.8 1.9e-10 40.7 0.5 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix domain RecA PF00154.16 EWC48383.1 - 1.7e-10 40.4 0.0 2.4e-10 39.9 0.0 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein KaiC PF06745.8 EWC48383.1 - 3.9e-06 26.1 0.0 5.9e-06 25.5 0.0 1.3 1 0 0 1 1 1 1 KaiC HHH PF00633.18 EWC48383.1 - 0.0086 15.7 0.1 0.019 14.6 0.1 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif AAA_22 PF13401.1 EWC48383.1 - 0.012 15.7 0.0 0.031 14.4 0.0 1.7 1 1 0 1 1 1 0 AAA domain PAXNEB PF05625.6 EWC48383.1 - 0.1 11.4 0.2 0.21 10.3 0.1 1.5 2 0 0 2 2 2 0 PAXNEB protein Dna2 PF08696.6 EWC48384.1 - 2e-63 213.5 0.0 3.6e-63 212.6 0.0 1.4 1 0 0 1 1 1 1 DNA replication factor Dna2 AAA_12 PF13087.1 EWC48384.1 - 3.8e-52 176.5 0.0 6.4e-52 175.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 EWC48384.1 - 2.5e-39 135.2 3.3 1.4e-19 70.5 0.1 2.8 2 1 1 3 3 3 2 AAA domain AAA_30 PF13604.1 EWC48384.1 - 1e-11 44.7 0.0 4e-11 42.8 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 EWC48384.1 - 2.5e-11 43.1 0.1 7.7e-11 41.6 0.1 1.8 1 0 0 1 1 1 1 Part of AAA domain Viral_helicase1 PF01443.13 EWC48384.1 - 3.2e-06 26.8 1.1 0.4 10.1 0.0 3.9 4 0 0 4 4 3 2 Viral (Superfamily 1) RNA helicase Cas_Cas4 PF01930.12 EWC48384.1 - 5.7e-06 26.3 0.0 2.3e-05 24.4 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function DUF83 Helicase_RecD PF05127.9 EWC48384.1 - 1.7e-05 24.5 0.0 3.9e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 Helicase UvrD-helicase PF00580.16 EWC48384.1 - 0.00014 21.2 0.0 0.00032 20.0 0.0 1.6 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain MobB PF03205.9 EWC48384.1 - 0.00092 18.9 0.1 0.0031 17.2 0.1 1.9 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B SRP54 PF00448.17 EWC48384.1 - 0.00098 18.6 0.1 0.0019 17.7 0.1 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_16 PF13191.1 EWC48384.1 - 0.0017 18.3 0.0 0.0065 16.4 0.0 2.1 1 0 0 1 1 1 1 AAA ATPase domain CbiA PF01656.18 EWC48384.1 - 0.0042 16.5 0.0 0.01 15.2 0.0 1.6 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain PIF1 PF05970.9 EWC48384.1 - 0.0055 15.7 0.1 0.089 11.7 0.1 2.2 2 0 0 2 2 2 1 PIF1-like helicase AAA_22 PF13401.1 EWC48384.1 - 0.0087 16.1 0.0 0.033 14.3 0.0 2.0 1 0 0 1 1 1 1 AAA domain ResIII PF04851.10 EWC48384.1 - 0.013 15.3 0.1 0.033 14.0 0.1 1.7 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit T2SE PF00437.15 EWC48384.1 - 0.023 13.6 0.0 0.046 12.6 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_25 PF13481.1 EWC48384.1 - 0.025 13.9 0.0 0.082 12.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain DUF87 PF01935.12 EWC48384.1 - 0.054 13.3 0.1 0.17 11.6 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function DUF87 FtsK_SpoIIIE PF01580.13 EWC48384.1 - 0.068 12.6 0.1 0.17 11.2 0.1 1.6 1 0 0 1 1 1 0 FtsK/SpoIIIE family ArgK PF03308.11 EWC48384.1 - 0.072 11.8 0.5 0.16 10.6 0.0 1.7 2 0 0 2 2 2 0 ArgK protein DUF2075 PF09848.4 EWC48384.1 - 0.097 11.6 0.0 0.17 10.8 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) cobW PF02492.14 EWC48384.1 - 0.11 11.9 0.0 0.21 11.0 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Mito_carr PF00153.22 EWC48385.1 - 8.2e-69 227.3 2.4 1.1e-24 85.9 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Tim17 PF02466.14 EWC48385.1 - 0.0079 16.2 2.1 0.057 13.4 0.0 2.9 3 0 0 3 3 3 1 Tim17/Tim22/Tim23/Pmp24 family Ank_5 PF13857.1 EWC48386.1 - 1.8e-14 53.4 0.3 1.2e-13 50.7 0.1 2.2 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.25 EWC48386.1 - 5.5e-13 48.0 2.5 3.9e-09 35.8 0.2 4.1 4 1 0 4 4 4 2 Ankyrin repeat Ank_2 PF12796.2 EWC48386.1 - 7.6e-12 45.4 0.1 2.4e-09 37.3 0.1 2.4 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 EWC48386.1 - 2.6e-10 40.5 1.4 1.3e-06 28.7 0.1 3.2 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 EWC48386.1 - 2.8e-08 33.2 0.6 1.4e-05 24.8 0.1 3.5 3 1 0 3 3 3 1 Ankyrin repeat Myb_DNA-binding PF00249.26 EWC48386.1 - 0.37 10.8 2.3 36 4.5 0.1 3.1 2 1 0 2 2 2 0 Myb-like DNA-binding domain Abhydrolase_2 PF02230.11 EWC48387.1 - 3.8e-26 91.8 0.0 5.3e-20 71.7 0.0 2.2 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Abhydrolase_5 PF12695.2 EWC48387.1 - 9.1e-05 22.2 0.0 0.00014 21.6 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 EWC48387.1 - 0.046 12.9 0.0 0.12 11.5 0.0 1.7 2 0 0 2 2 2 0 Prolyl oligopeptidase family UQ_con PF00179.21 EWC48389.1 - 4.4e-10 39.1 0.0 2.7e-08 33.3 0.0 2.0 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 EWC48389.1 - 0.072 12.9 0.0 0.072 12.9 0.0 1.2 1 0 0 1 1 1 0 RWD domain Sec7_N PF12783.2 EWC48390.1 - 7e-39 132.9 0.3 1.4e-37 128.6 0.0 3.2 3 0 0 3 3 3 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.5 EWC48390.1 - 2.2e-05 23.8 0.1 0.0014 18.0 0.0 3.2 2 0 0 2 2 2 1 Domain of unknown function (DUF1981) USP7_ICP0_bdg PF12436.3 EWC48390.1 - 0.2 10.8 0.0 0.37 9.9 0.0 1.3 1 0 0 1 1 1 0 ICP0-binding domain of Ubiquitin-specific protease 7 UPF0020 PF01170.13 EWC48391.1 - 2.9e-09 36.7 0.1 1.3e-08 34.6 0.0 1.9 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_26 PF13659.1 EWC48391.1 - 2.6e-07 30.6 0.0 7.4e-07 29.2 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain N6_N4_Mtase PF01555.13 EWC48391.1 - 0.14 11.5 0.0 0.65 9.4 0.0 2.0 2 0 0 2 2 2 0 DNA methylase Ribosomal_L2_C PF03947.13 EWC48392.1 - 2.1e-48 163.4 0.4 4.4e-48 162.3 0.3 1.6 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.18 EWC48392.1 - 5.1e-27 93.6 0.4 1.1e-26 92.5 0.3 1.6 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain Fungal_trans PF04082.13 EWC48393.1 - 1.6e-16 59.9 0.0 3.6e-16 58.8 0.0 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EWC48393.1 - 1.3e-09 37.7 9.0 2.5e-09 36.8 6.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RNA_polI_A34 PF08208.6 EWC48393.1 - 0.072 12.7 0.3 0.16 11.5 0.2 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 HIT PF01230.18 EWC48394.1 - 1.8e-14 54.0 0.0 1.6e-07 31.7 0.0 2.3 2 0 0 2 2 2 2 HIT domain DcpS_C PF11969.3 EWC48394.1 - 0.00035 20.7 0.0 0.039 14.1 0.0 2.4 2 0 0 2 2 2 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.10 EWC48394.1 - 0.0066 16.0 1.3 0.3 10.7 0.2 2.9 2 1 0 2 2 2 1 Protein similar to CwfJ C-terminus 1 DUF2946 PF11162.3 EWC48394.1 - 0.045 13.9 1.9 0.076 13.2 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2946) Cyclin_N PF00134.18 EWC48395.1 - 3.7e-47 159.0 0.0 1.5e-43 147.4 0.0 2.4 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.14 EWC48395.1 - 2.2e-34 117.9 0.1 4.9e-34 116.7 0.1 1.6 1 0 0 1 1 1 1 Cyclin, C-terminal domain FUSC_2 PF13515.1 EWC48396.1 - 2.8e-14 53.1 21.7 5.5e-13 48.9 4.0 2.5 2 0 0 2 2 2 2 Fusaric acid resistance protein-like DUF2422 PF10337.4 EWC48396.1 - 2.4e-12 46.4 12.6 2e-07 30.2 2.2 3.2 1 1 1 2 2 2 2 Protein of unknown function (DUF2422) ALMT PF11744.3 EWC48396.1 - 8.7e-08 31.2 2.3 9.5e-08 31.1 0.4 1.8 2 0 0 2 2 2 1 Aluminium activated malate transporter DUF2421 PF10334.4 EWC48396.1 - 3.5e-05 23.5 0.0 9e-05 22.1 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF2421) FUSC PF04632.7 EWC48396.1 - 8.6e-05 21.1 1.5 8.6e-05 21.1 1.0 2.7 2 1 1 3 3 3 1 Fusaric acid resistance protein family Bac_export_1 PF01311.15 EWC48396.1 - 0.0034 16.6 0.5 0.0034 16.6 0.4 1.8 2 0 0 2 2 2 1 Bacterial export proteins, family 1 DUF939 PF06081.6 EWC48396.1 - 0.0056 16.5 1.2 0.0056 16.5 0.8 2.3 2 0 0 2 2 2 1 Bacterial protein of unknown function (DUF939) WD40 PF00400.27 EWC48397.1 - 1.6e-24 84.8 6.2 4.6e-10 38.9 0.0 6.8 7 0 0 7 7 7 3 WD domain, G-beta repeat Nbas_N PF15492.1 EWC48397.1 - 0.00015 21.0 0.0 0.00088 18.4 0.0 2.1 1 1 1 2 2 2 1 Neuroblastoma-amplified sequence, N terminal Cytochrom_D1 PF02239.11 EWC48397.1 - 0.0013 17.1 0.1 0.49 8.6 0.0 2.1 1 1 1 2 2 2 2 Cytochrome D1 heme domain Ribonuc_P_40 PF08584.6 EWC48398.1 - 5.4e-65 219.2 0.0 8.9e-65 218.4 0.0 1.3 1 1 0 1 1 1 1 Ribonuclease P 40kDa (Rpp40) subunit La PF05383.12 EWC48399.1 - 5.5e-15 54.9 0.1 1.2e-14 53.8 0.1 1.5 1 0 0 1 1 1 1 La domain Got1 PF04178.7 EWC48400.1 - 3.1e-32 111.1 14.2 4.2e-32 110.7 9.8 1.2 1 0 0 1 1 1 1 Got1/Sft2-like family HLH PF00010.21 EWC48401.1 - 4.1e-12 45.6 0.0 1.1e-11 44.2 0.0 1.7 1 1 0 1 1 1 1 Helix-loop-helix DNA-binding domain RNA_lig_T4_1 PF09511.5 EWC48402.1 - 1.6e-78 263.2 0.0 2.3e-78 262.6 0.0 1.3 1 0 0 1 1 1 1 RNA ligase tRNA_lig_CPD PF08302.6 EWC48402.1 - 3.3e-36 124.8 0.0 5.5e-36 124.0 0.0 1.4 1 0 0 1 1 1 1 Fungal tRNA ligase phosphodiesterase domain tRNA_lig_kinase PF08303.6 EWC48402.1 - 4.2e-26 91.7 0.1 2e-24 86.3 0.0 2.4 1 1 1 2 2 2 1 tRNA ligase kinase domain CHCH PF06747.8 EWC48403.1 - 1.9e-05 24.4 0.3 2.9e-05 23.8 0.2 1.3 1 0 0 1 1 1 1 CHCH domain Pet191_N PF10203.4 EWC48403.1 - 0.0029 17.5 1.8 0.013 15.4 1.4 1.7 1 1 1 2 2 2 2 Cytochrome c oxidase assembly protein PET191 Cmc1 PF08583.5 EWC48403.1 - 0.018 14.8 1.0 0.027 14.2 0.7 1.3 1 0 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like COX17 PF05051.8 EWC48403.1 - 0.1 12.6 1.4 3.7 7.6 0.1 2.3 1 1 1 2 2 2 0 Cytochrome C oxidase copper chaperone (COX17) UPF0203 PF05254.7 EWC48403.1 - 0.15 11.9 1.2 9.9 6.1 0.1 2.0 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0203) SIR2 PF02146.12 EWC48404.1 - 6.5e-61 205.1 0.0 1.1e-60 204.3 0.0 1.4 1 0 0 1 1 1 1 Sir2 family DUF592 PF04574.8 EWC48404.1 - 0.00038 20.0 0.0 0.00081 18.9 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF592) TPP_enzyme_M PF00205.17 EWC48404.1 - 0.056 13.1 0.1 7.9 6.2 0.0 2.3 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain ATG16 PF08614.6 EWC48405.1 - 0.086 12.6 7.8 0.16 11.7 5.4 1.4 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) FliT PF05400.8 EWC48405.1 - 0.16 12.3 8.2 0.1 13.0 3.7 2.0 2 0 0 2 2 2 0 Flagellar protein FliT FlxA PF14282.1 EWC48406.1 - 0.0069 16.3 1.1 0.023 14.6 0.8 1.9 1 0 0 1 1 1 1 FlxA-like protein DUF3813 PF12758.2 EWC48406.1 - 0.078 13.1 2.7 0.12 12.5 0.5 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3813) Cofilin_ADF PF00241.15 EWC48407.1 - 4.7e-17 62.0 0.0 5.3e-17 61.8 0.0 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein NPR3 PF03666.8 EWC48408.1 - 8.1e-122 407.0 0.0 8.1e-122 407.0 0.0 1.7 2 0 0 2 2 2 1 Nitrogen Permease regulator of amino acid transport activity 3 zf-met PF12874.2 EWC48409.1 - 9e-06 25.7 1.2 1.7e-05 24.8 0.8 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type CactinC_cactus PF09732.4 EWC48409.1 - 6.5e-05 22.5 0.4 0.0001 21.8 0.3 1.3 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein PRP4 PF08799.6 EWC48409.1 - 0.18 11.1 2.1 0.33 10.2 1.5 1.5 1 0 0 1 1 1 0 pre-mRNA processing factor 4 (PRP4) like Abhydrolase_6 PF12697.2 EWC48410.1 - 4.6e-07 29.9 1.9 9.3e-07 28.9 1.3 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.8 EWC48410.1 - 3e-06 26.9 0.5 8.5e-06 25.4 0.3 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EWC48410.1 - 3.9e-05 23.4 0.0 5.9e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF3089 PF11288.3 EWC48410.1 - 0.0042 16.2 0.0 0.0063 15.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3089) DUF915 PF06028.6 EWC48410.1 - 0.024 13.7 0.0 0.038 13.0 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) DUF2263 PF10021.4 EWC48411.1 - 2.8e-19 69.5 0.0 1.9e-18 66.8 0.0 2.1 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2263) Mod_r PF07200.8 EWC48412.1 - 7.7e-09 35.6 0.3 0.00031 20.6 0.0 2.1 2 0 0 2 2 2 2 Modifier of rudimentary (Mod(r)) protein NARP1 PF12569.3 EWC48415.1 - 2.1e-177 590.9 16.8 4.5e-177 589.9 9.2 2.1 2 0 0 2 2 2 1 NMDA receptor-regulated protein 1 TPR_11 PF13414.1 EWC48415.1 - 2.6e-22 78.2 13.6 1.4e-06 27.8 0.0 6.9 7 0 0 7 7 7 4 TPR repeat TPR_19 PF14559.1 EWC48415.1 - 5.6e-18 65.0 18.5 4.3e-07 30.1 0.5 8.2 7 1 1 8 8 8 3 Tetratricopeptide repeat TPR_12 PF13424.1 EWC48415.1 - 7.4e-15 54.6 25.0 0.00056 19.7 1.0 8.0 7 1 1 8 8 8 4 Tetratricopeptide repeat TPR_2 PF07719.12 EWC48415.1 - 9.7e-15 53.2 27.1 8.2e-05 22.2 0.0 10.1 10 0 0 10 10 10 3 Tetratricopeptide repeat TPR_14 PF13428.1 EWC48415.1 - 1.1e-14 53.6 20.0 0.0018 18.7 0.0 10.4 10 1 2 12 12 9 3 Tetratricopeptide repeat TPR_1 PF00515.23 EWC48415.1 - 2.1e-14 52.4 15.7 6e-06 25.6 0.1 7.9 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_8 PF13181.1 EWC48415.1 - 7.6e-11 40.9 11.3 0.0049 16.5 0.0 7.6 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_16 PF13432.1 EWC48415.1 - 1.2e-10 41.7 19.2 0.012 16.2 0.3 7.4 6 1 3 9 9 8 4 Tetratricopeptide repeat TPR_9 PF13371.1 EWC48415.1 - 1.1e-09 38.0 9.9 0.00013 21.7 0.1 5.0 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.1 EWC48415.1 - 4.2e-09 35.9 3.8 0.17 12.1 0.0 6.6 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_7 PF13176.1 EWC48415.1 - 6.6e-05 22.4 10.6 0.052 13.3 0.1 6.3 6 0 0 6 6 6 2 Tetratricopeptide repeat Apc3 PF12895.2 EWC48415.1 - 0.00011 22.3 16.8 0.11 12.5 0.4 6.6 6 2 2 8 8 8 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_4 PF07721.9 EWC48415.1 - 0.00068 19.8 0.0 6.2 7.5 0.0 4.5 3 0 0 3 3 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 EWC48415.1 - 0.008 16.0 8.0 0.45 10.4 0.1 4.1 5 0 0 5 5 4 2 Fis1 C-terminal tetratricopeptide repeat Rapsyn_N PF10579.4 EWC48415.1 - 0.027 14.2 0.8 0.63 9.8 0.1 3.5 4 0 0 4 4 3 0 Rapsyn N-terminal myristoylation and linker region TPR_6 PF13174.1 EWC48415.1 - 0.11 13.0 24.9 0.84 10.2 0.1 8.4 9 0 0 9 9 7 0 Tetratricopeptide repeat Fapy_DNA_glyco PF01149.19 EWC48416.1 - 6.1e-24 84.6 0.0 1.4e-23 83.4 0.0 1.7 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase N-terminal domain H2TH PF06831.9 EWC48416.1 - 6.1e-16 57.9 0.0 1.1e-15 57.1 0.0 1.4 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase H2TH domain Nucleoplasmin PF03066.10 EWC48416.1 - 0.41 10.1 15.2 0.71 9.3 3.5 2.3 2 0 0 2 2 2 0 Nucleoplasmin ORC6 PF05460.8 EWC48416.1 - 0.53 9.3 11.0 0.53 9.3 6.8 1.6 2 0 0 2 2 2 0 Origin recognition complex subunit 6 (ORC6) TFIIF_alpha PF05793.7 EWC48416.1 - 1.6 7.0 26.1 2.4 6.4 18.1 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) BSP_II PF05432.6 EWC48416.1 - 3 7.0 28.1 20 4.3 19.4 1.9 1 1 0 1 1 1 0 Bone sialoprotein II (BSP-II) PPP4R2 PF09184.6 EWC48416.1 - 3 7.2 15.6 5.2 6.5 10.8 1.3 1 0 0 1 1 1 0 PPP4R2 Nop14 PF04147.7 EWC48416.1 - 5.7 4.7 17.3 7.9 4.2 12.0 1.1 1 0 0 1 1 1 0 Nop14-like family CDC27 PF09507.5 EWC48416.1 - 9.4 5.3 25.8 12 5.0 17.9 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 AdoHcyase PF05221.12 EWC48417.1 - 7.3e-136 451.3 0.1 8.6e-136 451.1 0.1 1.0 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.16 EWC48417.1 - 1.2e-84 282.0 4.5 2.2e-84 281.2 3.1 1.5 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.14 EWC48417.1 - 4.5e-09 35.7 0.2 9.3e-09 34.6 0.2 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.7 EWC48417.1 - 0.00045 19.6 0.6 0.00078 18.8 0.4 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain ELFV_dehydrog PF00208.16 EWC48417.1 - 0.0083 15.7 0.2 0.014 14.9 0.1 1.5 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase DUF4448 PF14610.1 EWC48417.1 - 0.059 12.8 0.0 0.095 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) TrkA_N PF02254.13 EWC48417.1 - 0.064 13.2 0.2 0.14 12.1 0.1 1.7 1 1 0 1 1 1 0 TrkA-N domain DASH_Dad1 PF08649.5 EWC48418.1 - 7e-23 80.0 0.3 8e-23 79.8 0.2 1.0 1 0 0 1 1 1 1 DASH complex subunit Dad1 DnaG_DnaB_bind PF08278.6 EWC48419.1 - 0.08 13.1 0.0 0.18 12.0 0.0 1.6 1 0 0 1 1 1 0 DNA primase DnaG DnaB-binding Cid2 PF09774.4 EWC48420.1 - 1.2e-36 126.0 0.0 1.7e-36 125.5 0.0 1.2 1 0 0 1 1 1 1 Caffeine-induced death protein 2 DUF761 PF05553.6 EWC48420.1 - 0.24 10.8 1.0 0.54 9.6 0.7 1.5 1 0 0 1 1 1 0 Cotton fibre expressed protein TPR_11 PF13414.1 EWC48421.1 - 4.7e-09 35.7 2.1 0.05 13.2 0.1 4.2 2 1 0 3 3 3 3 TPR repeat TPR_16 PF13432.1 EWC48421.1 - 1.3e-07 32.0 3.2 0.047 14.3 0.0 4.8 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.1 EWC48421.1 - 9.7e-07 28.8 7.6 1.1 10.1 0.3 6.0 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_2 PF07719.12 EWC48421.1 - 7.4e-06 25.4 0.1 0.2 11.6 0.0 5.1 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_9 PF13371.1 EWC48421.1 - 8.1e-05 22.3 7.8 0.0016 18.2 0.0 4.2 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_19 PF14559.1 EWC48421.1 - 0.00031 21.0 4.8 7.7 6.9 0.0 5.0 4 1 2 6 6 6 1 Tetratricopeptide repeat TPR_1 PF00515.23 EWC48421.1 - 0.0012 18.3 0.0 1.5 8.5 0.0 4.4 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_12 PF13424.1 EWC48421.1 - 0.0018 18.1 0.4 9.3 6.2 0.0 4.4 3 2 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.1 EWC48421.1 - 0.0019 17.8 3.5 1.6 8.6 0.0 4.8 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_17 PF13431.1 EWC48421.1 - 0.0046 17.0 0.2 14 6.1 0.0 4.9 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_6 PF13174.1 EWC48421.1 - 0.0095 16.3 0.9 1e+02 3.6 0.0 5.2 5 1 1 6 6 5 0 Tetratricopeptide repeat MIT PF04212.13 EWC48421.1 - 0.083 12.7 0.2 0.52 10.2 0.1 2.3 1 1 0 1 1 1 0 MIT (microtubule interacting and transport) domain RWD PF05773.17 EWC48422.1 - 1.8e-22 79.3 0.3 2.8e-22 78.7 0.2 1.3 1 0 0 1 1 1 1 RWD domain DUF501 PF04417.7 EWC48422.1 - 0.85 9.4 6.2 1.1 9.1 3.7 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF501) Aminotran_3 PF00202.16 EWC48423.1 - 6e-87 291.6 0.0 7.2e-87 291.3 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Fungal_trans PF04082.13 EWC48424.1 - 1.1e-18 67.0 0.0 2.3e-17 62.7 0.0 2.2 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EWC48424.1 - 4.1e-06 26.5 5.7 6.9e-06 25.8 4.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Synaptobrevin PF00957.16 EWC48426.1 - 1.3e-14 53.5 0.6 2e-14 52.9 0.4 1.3 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.1 EWC48426.1 - 4.6e-12 45.3 0.0 9.6e-12 44.3 0.0 1.6 1 1 0 1 1 1 1 Regulated-SNARE-like domain 2-Hacid_dh_C PF02826.14 EWC48427.1 - 3.3e-54 182.7 0.0 4.7e-54 182.2 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 EWC48427.1 - 4.5e-15 55.2 0.0 6.1e-15 54.8 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.10 EWC48427.1 - 0.014 15.1 0.1 0.028 14.2 0.1 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase NB-ARC PF00931.17 EWC48427.1 - 0.09 11.6 0.2 0.15 10.9 0.1 1.2 1 0 0 1 1 1 0 NB-ARC domain GATase_2 PF00310.16 EWC48428.1 - 1.6e-21 76.4 0.1 3.7e-17 62.0 0.0 2.6 2 1 1 3 3 3 2 Glutamine amidotransferases class-II GATase_6 PF13522.1 EWC48428.1 - 3e-17 62.8 0.0 7e-17 61.6 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.1 EWC48428.1 - 6.8e-15 54.9 0.0 1.5e-14 53.8 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain Pribosyltran PF00156.22 EWC48428.1 - 1.1e-10 41.2 0.1 2.3e-10 40.2 0.1 1.5 1 0 0 1 1 1 1 Phosphoribosyl transferase domain GATase_4 PF13230.1 EWC48428.1 - 0.00049 18.8 0.0 0.0008 18.1 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferases class-II ADH_zinc_N PF00107.21 EWC48428.1 - 0.0042 16.6 0.5 1.6 8.3 0.0 3.3 3 1 1 4 4 4 2 Zinc-binding dehydrogenase YchF-GTPase_C PF06071.8 EWC48429.1 - 1.6e-35 120.7 1.8 2.5e-35 120.1 0.3 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.18 EWC48429.1 - 4.8e-12 45.8 0.0 3.3e-11 43.1 0.0 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase TGS PF02824.16 EWC48429.1 - 0.0013 18.5 0.1 0.0029 17.4 0.1 1.6 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.13 EWC48429.1 - 0.0031 16.8 0.0 0.0062 15.8 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B MobB PF03205.9 EWC48429.1 - 0.0041 16.8 0.2 4.2 7.0 0.0 2.7 2 0 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B RPAP1_N PF08621.5 EWC48429.1 - 0.69 9.5 2.8 1.3 8.7 2.0 1.4 1 0 0 1 1 1 0 RPAP1-like, N-terminal Peptidase_C97 PF05903.9 EWC48430.1 - 1.2e-33 116.0 0.0 1.5e-33 115.7 0.0 1.1 1 0 0 1 1 1 1 PPPDE putative peptidase domain LRAT PF04970.8 EWC48430.1 - 0.051 13.5 0.1 0.082 12.8 0.0 1.2 1 0 0 1 1 1 0 Lecithin retinol acyltransferase Inhibitor_I78 PF11720.3 EWC48431.1 - 3.2e-11 42.7 0.0 4.4e-11 42.3 0.0 1.2 1 0 0 1 1 1 1 Peptidase inhibitor I78 family potato_inhibit PF00280.13 EWC48431.1 - 0.0051 16.9 0.2 0.0094 16.0 0.2 1.6 1 1 0 1 1 1 1 Potato inhibitor I family Ank_5 PF13857.1 EWC48432.1 - 3.2e-18 65.3 2.4 3.3e-11 43.0 0.0 6.4 6 1 1 7 7 7 2 Ankyrin repeats (many copies) Ank_4 PF13637.1 EWC48432.1 - 1.2e-13 51.1 1.7 0.00041 20.7 0.0 6.1 5 1 1 6 6 6 4 Ankyrin repeats (many copies) VPS9 PF02204.13 EWC48432.1 - 2.7e-13 49.8 0.0 6.7e-13 48.5 0.0 1.7 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain Ank_2 PF12796.2 EWC48432.1 - 3.4e-13 49.7 0.1 2.3e-06 27.8 0.0 4.1 3 1 1 4 4 4 2 Ankyrin repeats (3 copies) Ank PF00023.25 EWC48432.1 - 1.6e-09 37.0 0.0 0.63 9.9 0.0 6.1 5 1 0 5 5 5 2 Ankyrin repeat Ank_3 PF13606.1 EWC48432.1 - 3.5e-06 26.7 0.1 4.7 7.7 0.0 6.2 6 1 0 6 6 6 1 Ankyrin repeat PX PF00787.19 EWC48432.1 - 0.00028 20.6 0.1 0.0011 18.7 0.1 2.1 1 0 0 1 1 1 1 PX domain Zn_clus PF00172.13 EWC48433.1 - 6.7e-08 32.3 10.2 1.1e-07 31.6 7.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CwfJ_C_1 PF04677.10 EWC48434.1 - 9.1e-31 106.0 0.0 1.5e-30 105.3 0.0 1.4 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.9 EWC48434.1 - 4e-26 91.3 0.1 1.2e-25 89.7 0.1 1.9 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 ATP_bind_1 PF03029.12 EWC48435.1 - 2.6e-81 272.6 0.2 4e-81 272.0 0.2 1.3 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.22 EWC48435.1 - 7.6e-06 25.4 0.3 0.00018 20.9 0.2 2.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_17 PF13207.1 EWC48435.1 - 7.5e-05 23.5 0.1 0.0012 19.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain ArgK PF03308.11 EWC48435.1 - 0.0001 21.1 0.2 0.11 11.2 0.1 2.3 2 0 0 2 2 2 2 ArgK protein AAA_10 PF12846.2 EWC48435.1 - 0.00033 20.2 0.1 0.00062 19.3 0.1 1.7 1 1 0 1 1 1 1 AAA-like domain cobW PF02492.14 EWC48435.1 - 0.00063 19.2 0.0 0.0025 17.3 0.0 2.0 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain SRP54 PF00448.17 EWC48435.1 - 0.001 18.5 0.0 0.0027 17.1 0.0 1.7 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain MMR_HSR1 PF01926.18 EWC48435.1 - 0.001 19.0 0.0 0.0027 17.6 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.1 EWC48435.1 - 0.0011 19.1 0.0 0.0033 17.5 0.0 1.9 2 0 0 2 2 1 1 AAA domain AAA_33 PF13671.1 EWC48435.1 - 0.0012 18.7 0.4 0.0021 17.9 0.0 1.8 2 1 0 2 2 1 1 AAA domain Arf PF00025.16 EWC48435.1 - 0.0016 17.7 0.0 1.3 8.2 0.0 2.7 2 1 0 2 2 2 2 ADP-ribosylation factor family NACHT PF05729.7 EWC48435.1 - 0.0035 17.0 0.0 0.0061 16.2 0.0 1.3 1 0 0 1 1 1 1 NACHT domain PRK PF00485.13 EWC48435.1 - 0.0043 16.6 0.0 0.097 12.2 0.0 2.3 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family DUF87 PF01935.12 EWC48435.1 - 0.0095 15.7 0.3 0.25 11.1 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function DUF87 MobB PF03205.9 EWC48435.1 - 0.0096 15.6 0.0 0.024 14.3 0.0 1.6 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_18 PF13238.1 EWC48435.1 - 0.0098 16.2 1.1 0.06 13.6 0.0 2.6 3 0 0 3 3 2 1 AAA domain FeoB_N PF02421.13 EWC48435.1 - 0.01 15.0 0.0 0.1 11.8 0.0 2.4 3 0 0 3 3 3 0 Ferrous iron transport protein B KAP_NTPase PF07693.9 EWC48435.1 - 0.016 14.1 0.5 0.16 10.9 0.3 2.1 1 1 0 1 1 1 0 KAP family P-loop domain Miro PF08477.8 EWC48435.1 - 0.027 14.9 0.0 0.75 10.2 0.0 2.5 2 0 0 2 2 2 0 Miro-like protein CbiA PF01656.18 EWC48435.1 - 0.029 13.7 0.1 0.094 12.1 0.0 1.9 2 1 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain PduV-EutP PF10662.4 EWC48435.1 - 0.03 13.7 0.1 0.25 10.8 0.0 2.4 3 1 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation Thymidylate_kin PF02223.12 EWC48435.1 - 0.031 13.6 0.5 0.21 10.9 0.0 2.1 2 0 0 2 2 2 0 Thymidylate kinase AAA_30 PF13604.1 EWC48435.1 - 0.046 13.3 0.0 0.082 12.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.17 EWC48435.1 - 0.06 12.1 0.9 0.12 11.2 0.0 1.9 2 1 0 2 2 2 0 NB-ARC domain FtsK_SpoIIIE PF01580.13 EWC48435.1 - 0.068 12.6 0.6 0.73 9.2 0.0 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family Asp_Glu_race PF01177.17 EWC48435.1 - 0.069 13.0 0.0 0.45 10.4 0.0 2.1 2 0 0 2 2 2 0 Asp/Glu/Hydantoin racemase AAA_14 PF13173.1 EWC48435.1 - 0.079 12.8 0.0 0.59 10.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.1 EWC48435.1 - 0.081 12.9 0.0 0.19 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain SPX PF03105.14 EWC48435.1 - 0.099 12.4 6.2 0.17 11.6 4.3 1.3 1 0 0 1 1 1 0 SPX domain Phage_Gp23 PF10669.4 EWC48435.1 - 0.7 10.0 5.4 1.8 8.6 3.7 1.7 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) AAA_23 PF13476.1 EWC48435.1 - 1.7 8.9 5.1 13 5.9 3.1 2.2 1 1 0 1 1 1 0 AAA domain Dynamin_N PF00350.18 EWC48435.1 - 2.4 7.9 5.8 35 4.1 0.0 3.7 2 1 1 4 4 4 0 Dynamin family APP_E2 PF12925.2 EWC48435.1 - 2.6 7.5 7.8 0.29 10.7 1.5 2.3 3 0 0 3 3 2 0 E2 domain of amyloid precursor protein TPR_14 PF13428.1 EWC48436.1 - 2.6e-26 89.7 12.4 0.0036 17.8 0.3 11.9 5 3 8 13 13 13 6 Tetratricopeptide repeat TPR_16 PF13432.1 EWC48436.1 - 1.8e-23 82.6 2.0 0.00028 21.4 0.0 7.0 6 1 2 8 8 8 7 Tetratricopeptide repeat HAT PF02184.11 EWC48436.1 - 1.1e-22 79.4 65.0 1.2e-13 50.4 1.4 13.6 14 0 0 14 14 14 5 HAT (Half-A-TPR) repeat TPR_19 PF14559.1 EWC48436.1 - 1.4e-21 76.6 0.0 6.6e-06 26.3 0.0 6.6 5 1 2 7 7 7 4 Tetratricopeptide repeat Suf PF05843.9 EWC48436.1 - 2.8e-13 50.2 25.4 0.0023 17.7 0.7 7.0 4 2 4 8 8 8 5 Suppressor of forked protein (Suf) TPR_11 PF13414.1 EWC48436.1 - 7.4e-13 47.9 0.6 0.23 11.1 0.1 5.7 5 0 0 5 5 5 4 TPR repeat TPR_17 PF13431.1 EWC48436.1 - 2.4e-11 42.8 0.2 0.0036 17.3 0.0 4.9 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 EWC48436.1 - 5.3e-10 38.4 6.6 0.071 13.0 0.0 8.1 10 0 0 10 10 9 3 Tetratricopeptide repeat TPR_15 PF13429.1 EWC48436.1 - 1.9e-08 33.7 15.2 0.011 14.8 0.1 4.9 4 2 1 5 5 5 4 Tetratricopeptide repeat TPR_12 PF13424.1 EWC48436.1 - 7.6e-07 28.9 13.4 1.6 8.7 0.2 6.9 7 2 1 8 8 7 4 Tetratricopeptide repeat TPR_1 PF00515.23 EWC48436.1 - 2.1e-05 23.8 2.3 4.8 6.9 0.0 6.0 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_7 PF13176.1 EWC48436.1 - 2.3e-05 23.8 8.8 2.4 8.1 0.0 5.8 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.1 EWC48436.1 - 0.0003 20.3 0.1 5.3 7.0 0.1 5.3 5 0 0 5 5 5 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 EWC48436.1 - 0.00057 19.7 1.5 9.9 6.1 0.0 5.1 5 0 0 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.1 EWC48436.1 - 0.0034 17.7 15.4 19 5.9 0.0 7.8 8 1 1 9 9 8 0 Tetratricopeptide repeat U3_assoc_6 PF08640.6 EWC48436.1 - 0.0036 17.0 21.2 0.31 10.8 0.7 7.3 4 3 2 7 7 7 2 U3 small nucleolar RNA-associated protein 6 PPTA PF01239.17 EWC48436.1 - 0.01 15.1 1.0 0.86 9.0 0.1 2.6 2 0 0 2 2 2 0 Protein prenyltransferase alpha subunit repeat MRI PF15325.1 EWC48437.1 - 0.47 11.4 3.0 0.65 10.9 2.1 1.3 1 0 0 1 1 1 0 Modulator of retrovirus infection Rtf2 PF04641.7 EWC48437.1 - 2 7.5 5.6 2.6 7.1 3.9 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger BTV_NS2 PF04514.7 EWC48437.1 - 4.1 6.1 7.3 7.5 5.3 5.1 1.4 1 1 0 1 1 1 0 Bluetongue virus non-structural protein NS2 CFEM PF05730.6 EWC48438.1 - 0.045 13.5 11.6 0.083 12.7 8.0 1.4 1 0 0 1 1 1 0 CFEM domain TMEM154 PF15102.1 EWC48438.1 - 0.045 13.4 5.8 0.073 12.7 3.2 2.0 1 1 0 1 1 1 0 TMEM154 protein family EphA2_TM PF14575.1 EWC48438.1 - 0.08 13.3 0.0 0.49 10.8 0.0 2.3 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Orthoreo_P10 PF07204.6 EWC48438.1 - 0.096 12.4 0.0 0.23 11.2 0.0 1.6 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 DUF1517 PF07466.6 EWC48438.1 - 0.15 11.0 0.0 0.15 11.0 0.0 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF1517) NACHT PF05729.7 EWC48439.1 - 0.00011 21.8 0.1 0.0011 18.6 0.0 2.5 2 1 0 2 2 2 1 NACHT domain AAA_22 PF13401.1 EWC48439.1 - 0.012 15.7 0.0 0.12 12.5 0.0 2.6 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 EWC48439.1 - 0.089 12.9 0.0 0.22 11.7 0.0 1.7 1 0 0 1 1 1 0 RNA helicase Tim54 PF11711.3 EWC48440.1 - 7.5e-112 373.6 0.8 8.6e-112 373.4 0.6 1.0 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 JAB PF01398.16 EWC48441.1 - 1.7e-11 43.8 0.0 4.9e-11 42.3 0.0 1.8 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Pox_L5 PF04872.8 EWC48441.1 - 0.036 13.7 0.1 0.087 12.4 0.0 1.6 1 0 0 1 1 1 0 Poxvirus L5 protein family AA_permease_2 PF13520.1 EWC48442.1 - 3.3e-44 151.1 42.6 4.3e-44 150.7 29.5 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EWC48442.1 - 1.6e-22 79.5 35.7 2.1e-22 79.1 24.8 1.2 1 0 0 1 1 1 1 Amino acid permease zf-H2C2_2 PF13465.1 EWC48443.1 - 5.9e-08 32.6 8.2 1.2e-06 28.4 0.7 3.4 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2 PF00096.21 EWC48443.1 - 2e-05 24.6 0.4 2e-05 24.6 0.3 4.1 4 1 0 4 4 4 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EWC48443.1 - 9.4e-05 22.4 0.3 9.4e-05 22.4 0.2 3.6 4 0 0 4 4 4 1 C2H2-type zinc finger DUF349 PF03993.7 EWC48443.1 - 0.0098 16.0 0.5 0.082 13.0 1.1 1.8 2 0 0 2 2 2 1 Domain of Unknown Function (DUF349) zf-C2H2_jaz PF12171.3 EWC48443.1 - 0.012 15.6 5.9 0.65 10.2 0.1 3.6 3 1 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 EWC48443.1 - 0.47 10.7 2.4 7.2 6.9 0.0 2.7 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-Di19 PF05605.7 EWC48443.1 - 3.1 8.0 8.1 3.9 7.6 0.4 2.5 1 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding adh_short PF00106.20 EWC48445.1 - 4e-36 124.4 3.0 6.1e-36 123.8 2.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EWC48445.1 - 1.3e-16 60.8 0.8 1.7e-16 60.3 0.5 1.2 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 EWC48445.1 - 8.8e-16 58.4 0.2 1.2e-15 58.0 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Eno-Rase_NADH_b PF12242.3 EWC48445.1 - 6e-05 22.7 0.9 0.00012 21.7 0.4 1.7 1 1 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Epimerase PF01370.16 EWC48445.1 - 0.0008 18.9 0.2 0.0013 18.2 0.1 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 EWC48445.1 - 0.021 14.8 4.7 0.059 13.3 3.2 1.9 1 1 0 1 1 1 0 NADH(P)-binding NAD_binding_4 PF07993.7 EWC48445.1 - 0.029 13.2 1.0 0.047 12.6 0.7 1.5 1 1 0 1 1 1 0 Male sterility protein ApbA PF02558.11 EWC48445.1 - 0.084 12.3 0.1 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA THF_DHG_CYH_C PF02882.14 EWC48445.1 - 0.088 11.8 1.9 0.49 9.4 1.3 2.2 1 1 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Pkinase PF00069.20 EWC48446.1 - 3.1e-59 200.2 0.4 4.5e-40 137.4 0.1 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 EWC48446.1 - 4.9e-27 94.6 0.5 1e-20 73.9 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_C PF00433.19 EWC48446.1 - 0.00035 21.0 0.0 0.00075 19.9 0.0 1.6 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.1 EWC48446.1 - 0.0013 17.8 0.0 0.0021 17.0 0.0 1.5 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 EWC48446.1 - 0.0042 16.8 0.1 0.16 11.6 0.1 2.5 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 EWC48446.1 - 0.0059 15.6 0.0 0.012 14.6 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.6 EWC48446.1 - 0.045 12.5 0.1 0.074 11.8 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Seadorna_VP7 PF07387.6 EWC48446.1 - 0.11 11.3 0.0 0.17 10.6 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Ribosomal_S11 PF00411.14 EWC48447.1 - 1.9e-13 50.5 0.2 3.3e-13 49.7 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein S11 TAP_C PF03943.8 EWC48447.1 - 0.14 11.5 0.0 0.28 10.6 0.0 1.4 1 0 0 1 1 1 0 TAP C-terminal domain Kelch_6 PF13964.1 EWC48448.1 - 5.1e-07 29.5 5.2 0.067 13.4 0.0 4.6 3 1 1 4 4 4 2 Kelch motif TMEM154 PF15102.1 EWC48448.1 - 4.4e-05 23.2 0.1 8.1e-05 22.3 0.1 1.4 1 0 0 1 1 1 1 TMEM154 protein family Kelch_1 PF01344.20 EWC48448.1 - 0.00011 21.6 1.5 1.4 8.5 0.0 3.6 3 0 0 3 3 3 3 Kelch motif Rifin_STEVOR PF02009.11 EWC48448.1 - 0.00028 20.6 0.0 0.00047 19.9 0.0 1.2 1 0 0 1 1 1 1 Rifin/stevor family Kelch_5 PF13854.1 EWC48448.1 - 0.00069 19.5 1.0 2.1 8.4 0.0 4.7 4 0 0 4 4 4 1 Kelch motif BatD PF13584.1 EWC48448.1 - 0.01 14.5 0.0 0.016 13.7 0.0 1.2 1 0 0 1 1 1 1 Oxygen tolerance DUF4366 PF14283.1 EWC48448.1 - 0.012 15.0 0.0 0.021 14.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) Herpes_gE PF02480.11 EWC48448.1 - 0.037 12.2 0.1 0.058 11.6 0.0 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E zf-U1 PF06220.7 EWC48449.1 - 1.5e-07 30.8 0.4 3.2e-07 29.7 0.3 1.6 1 0 0 1 1 1 1 U1 zinc finger DUF2848 PF11010.3 EWC48449.1 - 0.11 11.9 0.0 0.29 10.5 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2848) DUF3806 PF12713.2 EWC48449.1 - 0.12 11.8 0.0 0.24 10.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3806) PUA PF01472.15 EWC48450.1 - 6.8e-16 57.7 0.0 2.7e-15 55.8 0.0 2.1 2 0 0 2 2 2 1 PUA domain CAP_GLY PF01302.20 EWC48451.1 - 3.6e-19 68.2 0.2 5.5e-19 67.6 0.1 1.3 1 0 0 1 1 1 1 CAP-Gly domain LRR_4 PF12799.2 EWC48451.1 - 2.4e-14 52.5 1.2 3.3e-05 23.3 0.3 4.6 5 1 0 5 5 5 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 EWC48451.1 - 2.5e-08 33.5 1.9 0.016 14.9 0.2 3.8 3 1 0 3 3 3 2 Leucine rich repeat LRR_6 PF13516.1 EWC48451.1 - 3.2e-07 29.7 1.3 3.2 8.1 0.0 6.2 6 0 0 6 6 6 1 Leucine Rich repeat LRR_1 PF00560.28 EWC48451.1 - 0.00017 21.1 4.3 32 5.1 0.0 6.6 6 0 0 6 6 6 0 Leucine Rich Repeat LRR_7 PF13504.1 EWC48451.1 - 0.00046 19.9 0.7 99 3.8 0.0 6.3 6 0 0 6 6 6 0 Leucine rich repeat Ubiquitin_2 PF14560.1 EWC48451.1 - 0.014 15.6 0.0 0.087 13.0 0.0 2.1 2 0 0 2 2 2 0 Ubiquitin-like domain Dor1 PF04124.7 EWC48451.1 - 0.021 13.2 0.1 0.036 12.5 0.1 1.3 1 0 0 1 1 1 0 Dor1-like family LRR_9 PF14580.1 EWC48451.1 - 0.12 11.8 1.5 0.88 9.0 0.1 2.7 2 1 1 3 3 3 0 Leucine-rich repeat zf-H2C2_2 PF13465.1 EWC48452.1 - 5e-08 32.8 13.2 2.5e-07 30.6 0.3 4.0 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2 PF00096.21 EWC48452.1 - 1.7e-06 27.9 13.5 0.0013 18.9 1.3 3.2 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EWC48452.1 - 5.1e-06 26.4 12.3 0.0014 18.8 1.1 3.1 3 0 0 3 3 3 2 C2H2-type zinc finger IBR PF01485.16 EWC48452.1 - 3.7 7.4 8.6 0.82 9.5 0.5 2.5 1 1 1 2 2 2 0 IBR domain Glycos_transf_3 PF00591.16 EWC48454.1 - 4.7e-64 216.2 0.0 6e-64 215.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family, a/b domain Glycos_trans_3N PF02885.12 EWC48454.1 - 0.0056 16.2 0.0 0.031 13.8 0.0 2.1 2 0 0 2 2 2 1 Glycosyl transferase family, helical bundle domain Tim44 PF04280.10 EWC48455.1 - 6e-32 110.6 0.5 1.3e-31 109.5 0.0 1.8 2 0 0 2 2 2 1 Tim44-like domain TPR_11 PF13414.1 EWC48456.1 - 6.4e-20 70.5 5.6 2.3e-16 59.1 0.6 2.6 1 1 1 2 2 2 2 TPR repeat TPR_1 PF00515.23 EWC48456.1 - 6e-17 60.4 1.7 1.5e-07 30.7 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.12 EWC48456.1 - 5.5e-15 54.0 2.3 1.6e-06 27.5 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.1 EWC48456.1 - 1.4e-09 38.3 13.7 1.5e-08 35.1 1.0 2.7 2 1 1 3 3 2 2 Tetratricopeptide repeat TPR_14 PF13428.1 EWC48456.1 - 6.5e-07 29.4 2.3 0.12 13.0 0.9 3.6 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.1 EWC48456.1 - 2.3e-05 24.6 2.9 0.00043 20.5 0.1 2.9 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.1 EWC48456.1 - 2.7e-05 24.0 2.7 0.019 15.1 0.1 3.0 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_12 PF13424.1 EWC48456.1 - 2.7e-05 24.0 5.0 0.013 15.4 0.1 2.6 1 1 1 2 2 2 2 Tetratricopeptide repeat XPC-binding PF09280.6 EWC48456.1 - 0.00025 20.4 0.8 0.00061 19.2 0.6 1.7 1 0 0 1 1 1 1 XPC-binding domain TPR_7 PF13176.1 EWC48456.1 - 0.00027 20.5 0.2 0.12 12.1 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat BTAD PF03704.12 EWC48456.1 - 0.0013 19.0 0.2 0.35 11.1 0.1 2.3 1 1 1 2 2 2 1 Bacterial transcriptional activator domain TPR_8 PF13181.1 EWC48456.1 - 0.0016 18.1 3.3 1.3 8.9 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_3 PF07720.7 EWC48456.1 - 0.043 13.6 0.0 0.13 12.0 0.0 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_6 PF13174.1 EWC48456.1 - 0.052 14.0 6.1 9.6 6.9 0.0 4.1 4 0 0 4 4 3 0 Tetratricopeptide repeat MIT PF04212.13 EWC48456.1 - 0.08 12.8 2.9 0.5 10.2 0.0 2.6 2 1 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_10 PF13374.1 EWC48456.1 - 0.13 12.1 0.7 17 5.5 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat Aldo_ket_red PF00248.16 EWC48457.1 - 1.6e-65 220.7 0.0 1.8e-65 220.5 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family HTH_Tnp_1 PF01527.15 EWC48457.1 - 0.013 15.4 0.0 3.1 7.8 0.0 2.6 1 1 1 2 2 2 0 Transposase DUF1002 PF06207.6 EWC48457.1 - 0.021 14.1 0.0 3.1 7.0 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1002) Kri1 PF05178.7 EWC48458.1 - 0.0021 18.3 4.3 0.0021 18.3 3.0 1.8 2 0 0 2 2 2 1 KRI1-like family GILT PF03227.11 EWC48459.1 - 1.2e-12 47.6 0.0 2.4e-12 46.6 0.0 1.5 1 0 0 1 1 1 1 Gamma interferon inducible lysosomal thiol reductase (GILT) Corona_nucleoca PF00937.13 EWC48460.1 - 0.13 11.1 3.5 0.18 10.7 2.5 1.1 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein Aldedh PF00171.17 EWC48461.1 - 9.7e-126 419.7 0.0 1.1e-125 419.6 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.9 EWC48461.1 - 1.3e-05 24.0 0.0 4.4e-05 22.3 0.0 1.7 1 1 0 1 1 1 1 Acyl-CoA reductase (LuxC) SIMPL PF04402.9 EWC48461.1 - 0.011 15.5 0.2 0.02 14.7 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF541) Clr2 PF10383.4 EWC48462.1 - 1.1e-06 28.6 0.0 1.1e-05 25.4 0.0 2.4 1 1 0 1 1 1 1 Transcription-silencing protein Clr2 Fungal_trans PF04082.13 EWC48463.1 - 6.7e-23 80.8 0.1 3.3e-19 68.7 0.0 2.5 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.13 EWC48463.1 - 6e-07 29.2 13.1 9.9e-07 28.5 9.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAT1 PF09770.4 EWC48463.1 - 8.8 4.4 18.4 13 3.8 12.7 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Pkinase PF00069.20 EWC48464.1 - 3e-31 108.5 0.0 8.3e-18 64.4 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 EWC48464.1 - 1.3e-14 53.9 0.0 2.9e-07 29.8 0.0 3.3 2 1 0 2 2 2 2 Protein tyrosine kinase Kdo PF06293.9 EWC48464.1 - 0.012 14.6 0.1 0.029 13.4 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Daxx PF03344.10 EWC48464.1 - 8.7 4.6 26.4 0.023 13.2 10.1 2.0 2 0 0 2 2 2 0 Daxx Family Methyltransf_23 PF13489.1 EWC48465.1 - 3.5e-23 82.1 0.0 7e-23 81.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EWC48465.1 - 4.1e-09 36.2 0.0 1.7e-08 34.2 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EWC48465.1 - 1.4e-08 35.2 0.0 3.5e-08 34.0 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EWC48465.1 - 6e-08 33.0 0.0 2.8e-07 30.9 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EWC48465.1 - 1.1e-06 29.0 0.0 2.2e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EWC48465.1 - 0.002 17.4 0.0 0.0043 16.4 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase small domain CMAS PF02353.15 EWC48465.1 - 0.0081 15.2 0.0 0.013 14.5 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_25 PF13649.1 EWC48465.1 - 0.01 16.1 0.0 0.022 15.1 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_26 PF13659.1 EWC48465.1 - 0.019 15.0 0.0 0.04 13.9 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain PrmA PF06325.8 EWC48465.1 - 0.019 14.1 0.0 0.025 13.6 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_16 PF10294.4 EWC48465.1 - 0.019 14.4 0.0 0.029 13.8 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_4 PF02390.12 EWC48465.1 - 0.038 13.0 0.0 0.062 12.3 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase Ubie_methyltran PF01209.13 EWC48465.1 - 0.042 12.9 0.0 0.096 11.7 0.0 1.7 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family Fungal_trans PF04082.13 EWC48466.1 - 8.9e-27 93.5 0.0 1.8e-26 92.5 0.0 1.5 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EWC48466.1 - 7.7e-05 22.5 7.7 0.00013 21.7 5.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain E1-E2_ATPase PF00122.15 EWC48467.1 - 1e-46 158.8 0.6 1e-46 158.8 0.4 1.6 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.21 EWC48467.1 - 1.5e-30 107.2 0.1 2.8e-30 106.3 0.1 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 EWC48467.1 - 1.4e-12 48.2 0.0 2.7e-12 47.2 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 EWC48467.1 - 1.4e-05 24.8 0.0 0.004 16.7 0.0 2.6 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HMG_box PF00505.14 EWC48468.1 - 5.4e-13 48.9 0.1 8.1e-13 48.4 0.1 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 EWC48468.1 - 3.6e-10 40.0 0.1 5.5e-10 39.4 0.1 1.3 1 0 0 1 1 1 1 HMG-box domain HMG_box_5 PF14887.1 EWC48468.1 - 0.019 14.7 0.1 0.037 13.8 0.0 1.4 1 0 0 1 1 1 0 HMG (high mobility group) box 5 Hemerythrin PF01814.18 EWC48470.1 - 1.5e-12 47.8 0.9 2.7e-12 46.9 0.6 1.4 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain DUF1445 PF07286.7 EWC48472.1 - 9.8e-39 132.2 0.0 1.5e-38 131.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1445) Peptidase_S8 PF00082.17 EWC48474.1 - 1.8e-20 73.2 0.8 4.1e-20 72.0 0.6 1.6 1 1 0 1 1 1 1 Subtilase family Chromo PF00385.19 EWC48476.1 - 0.00065 19.3 6.0 0.0055 16.3 0.1 2.9 3 0 0 3 3 3 2 Chromo (CHRromatin Organisation MOdifier) domain Nefa_Nip30_N PF10187.4 EWC48477.1 - 1.2e-24 86.4 5.6 1.2e-24 86.4 3.9 2.0 2 1 0 2 2 2 1 N-terminal domain of NEFA-interacting nuclear protein NIP30 DUF572 PF04502.8 EWC48477.1 - 0.038 13.2 11.0 0.059 12.5 7.6 1.3 1 1 0 1 1 1 0 Family of unknown function (DUF572) SPX PF03105.14 EWC48477.1 - 0.064 13.0 6.5 0.073 12.8 4.5 1.2 1 0 0 1 1 1 0 SPX domain RTA1 PF04479.8 EWC48478.1 - 1.7e-45 155.2 2.5 1.7e-45 155.2 1.8 1.4 2 0 0 2 2 2 1 RTA1 like protein PKD_channel PF08016.7 EWC48478.1 - 0.032 12.6 0.2 0.032 12.6 0.2 1.6 2 0 0 2 2 2 0 Polycystin cation channel DUF4131 PF13567.1 EWC48478.1 - 0.033 13.6 11.5 0.2 11.0 0.0 2.6 1 1 0 2 2 2 0 Domain of unknown function (DUF4131) HSP70 PF00012.15 EWC48479.1 - 1.1e-12 46.7 0.1 2.5e-12 45.5 0.1 1.5 1 1 0 1 1 1 1 Hsp70 protein zf-SAP30 PF13866.1 EWC48479.1 - 0.0045 16.6 0.1 0.0097 15.5 0.1 1.5 1 0 0 1 1 1 1 SAP30 zinc-finger MreB_Mbl PF06723.8 EWC48479.1 - 0.04 12.5 0.2 0.13 10.8 0.0 1.7 2 0 0 2 2 2 0 MreB/Mbl protein Pcc1 PF09341.5 EWC48480.1 - 4.6e-23 81.0 0.3 5.3e-23 80.8 0.2 1.1 1 0 0 1 1 1 1 Transcription factor Pcc1 Abhydrolase_6 PF12697.2 EWC48481.1 - 2.8e-15 56.8 8.7 4.5e-15 56.1 6.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EWC48481.1 - 0.0015 18.0 1.5 0.0062 16.1 0.7 2.2 1 1 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EWC48481.1 - 0.0031 17.2 0.2 0.0061 16.3 0.1 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Phosphoesterase PF04185.9 EWC48482.1 - 5.1e-35 121.3 1.8 8.8e-35 120.5 1.2 1.4 1 1 0 1 1 1 1 Phosphoesterase family Cu-oxidase_3 PF07732.10 EWC48483.1 - 2.5e-41 140.1 0.3 2.5e-41 140.1 0.2 2.7 2 1 0 2 2 2 1 Multicopper oxidase Cu-oxidase_2 PF07731.9 EWC48483.1 - 2e-37 127.7 3.9 7.2e-31 106.5 0.4 3.7 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.17 EWC48483.1 - 5.4e-29 101.1 0.0 4.6e-28 98.1 0.0 2.4 3 0 0 3 3 3 1 Multicopper oxidase UQ_con PF00179.21 EWC48484.1 - 3.9e-42 143.0 0.0 4.4e-42 142.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 EWC48484.1 - 0.012 15.3 0.0 0.022 14.5 0.0 1.4 1 1 0 1 1 1 0 Prokaryotic E2 family B UEV PF05743.8 EWC48484.1 - 0.013 15.1 0.1 0.025 14.2 0.0 1.5 2 0 0 2 2 2 0 UEV domain RWD PF05773.17 EWC48484.1 - 0.034 14.0 0.0 0.043 13.7 0.0 1.3 1 0 0 1 1 1 0 RWD domain DUF1713 PF08213.6 EWC48485.1 - 1.6e-14 53.1 21.6 3e-14 52.3 15.0 1.5 1 0 0 1 1 1 1 Mitochondrial domain of unknown function (DUF1713) EF_assoc_1 PF08355.7 EWC48485.1 - 0.13 11.5 0.8 0.42 9.9 0.6 2.0 1 1 0 1 1 1 0 EF hand associated DUF3117 PF11314.3 EWC48485.1 - 0.15 11.6 0.3 0.57 9.7 0.2 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3117) Mito_fiss_reg PF05308.6 EWC48485.1 - 1.3 8.3 5.7 0.26 10.6 0.4 1.8 2 0 0 2 2 2 0 Mitochondrial fission regulator Rrp15p PF07890.7 EWC48486.1 - 1.2e-19 70.5 1.7 1.5e-19 70.3 1.2 1.1 1 0 0 1 1 1 1 Rrp15p Fer2 PF00111.22 EWC48487.1 - 1.8e-12 46.8 1.1 2.3e-12 46.4 0.7 1.1 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain IF4E PF01652.13 EWC48488.1 - 1.3e-47 161.3 0.1 1.9e-47 160.8 0.1 1.2 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E MTHFR PF02219.12 EWC48489.1 - 9.5e-94 313.6 0.0 1.5e-93 312.9 0.0 1.3 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase Ribosomal_L22 PF00237.14 EWC48490.1 - 1.7e-19 69.6 0.1 3.4e-19 68.7 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e LMWPc PF01451.16 EWC48491.1 - 7.3e-25 87.8 0.0 8.5e-25 87.6 0.0 1.1 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase Chitin_synth_1 PF01644.12 EWC48492.1 - 7.9e-80 266.3 0.0 1.2e-79 265.7 0.0 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.6 EWC48492.1 - 4.4e-34 116.0 0.1 1.1e-33 114.7 0.1 1.7 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.10 EWC48492.1 - 4.5e-22 78.1 1.9 1.8e-16 59.6 0.0 2.2 2 0 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.1 EWC48492.1 - 2.1e-12 47.1 2.0 8.6e-12 45.1 1.3 2.1 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.1 EWC48492.1 - 5e-07 29.7 0.0 2.7e-06 27.3 0.0 2.0 2 0 0 2 2 2 1 Glycosyltransferase like family 2 IBR PF01485.16 EWC48493.1 - 1.8e-13 50.1 16.3 7e-10 38.6 4.4 6.2 4 1 0 4 4 4 3 IBR domain Nop10p PF04135.7 EWC48493.1 - 0.019 14.7 0.0 2 8.2 0.0 2.9 2 0 0 2 2 2 0 Nucleolar RNA-binding protein, Nop10p family zf-RING_2 PF13639.1 EWC48494.1 - 3.5e-11 42.7 6.2 6.2e-10 38.7 1.2 2.3 2 0 0 2 2 2 2 Ring finger domain zf-RING_5 PF14634.1 EWC48494.1 - 9.1e-08 31.7 1.5 3.5e-07 29.8 0.2 2.2 2 0 0 2 2 2 1 zinc-RING finger domain zf-rbx1 PF12678.2 EWC48494.1 - 4.1e-07 30.0 4.5 2.1e-06 27.7 3.1 2.0 1 1 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4 PF00097.20 EWC48494.1 - 5.2e-07 29.2 0.0 1.3e-06 27.9 0.0 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 EWC48494.1 - 7.1e-07 28.7 4.7 1.7e-06 27.6 0.8 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 EWC48494.1 - 2.6e-06 27.3 1.8 2.6e-06 27.3 1.2 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 EWC48494.1 - 0.00076 19.2 0.4 0.0018 18.0 0.3 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger PQ-loop PF04193.9 EWC48494.1 - 0.0062 16.0 0.4 0.011 15.2 0.3 1.4 1 0 0 1 1 1 1 PQ loop repeat zf-RING_UBOX PF13445.1 EWC48494.1 - 0.018 14.7 0.7 0.018 14.7 0.5 2.2 2 1 0 2 2 2 0 RING-type zinc-finger ThiG PF05690.9 EWC48494.1 - 0.063 12.3 0.8 0.092 11.8 0.6 1.2 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG FANCL_C PF11793.3 EWC48494.1 - 0.19 11.7 5.4 1.4 8.9 2.2 2.7 2 1 0 2 2 2 0 FANCL C-terminal domain RINGv PF12906.2 EWC48494.1 - 0.68 10.0 4.9 0.49 10.4 1.1 2.2 2 0 0 2 2 2 0 RING-variant domain CAP_C PF08603.6 EWC48495.1 - 1.4e-61 206.4 2.2 1.8e-61 206.1 1.5 1.1 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal CAP_N PF01213.14 EWC48495.1 - 2.1e-15 56.8 0.1 3.3e-15 56.1 0.1 1.3 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal TBCC PF07986.7 EWC48495.1 - 0.0062 15.9 0.3 0.081 12.3 0.3 2.1 1 1 1 2 2 2 1 Tubulin binding cofactor C Imm-NTF2-2 PF15631.1 EWC48495.1 - 0.021 14.8 0.3 2.5 8.1 0.0 2.4 2 1 0 2 2 2 0 NTF2 fold immunity protein DUF2360 PF10152.4 EWC48495.1 - 0.27 11.5 2.0 7.9 6.7 1.9 2.1 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein (DUF2360) BSP PF04450.7 EWC48498.1 - 5.8e-59 198.9 0.0 7.9e-59 198.5 0.0 1.2 1 0 0 1 1 1 1 Peptidase of plants and bacteria Peptidase_MA_2 PF13485.1 EWC48498.1 - 1.1e-06 28.6 0.5 3.1e-06 27.2 0.3 1.7 1 1 0 1 1 1 1 Peptidase MA superfamily SprT-like PF10263.4 EWC48498.1 - 0.06 13.0 0.1 0.097 12.3 0.0 1.3 1 0 0 1 1 1 0 SprT-like family MFS_1 PF07690.11 EWC48499.1 - 8.4e-26 90.5 18.4 4.6e-25 88.0 12.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Glyco_hydro_16 PF00722.16 EWC48500.1 - 6e-10 38.6 0.0 1.6e-09 37.3 0.0 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 16 LysM PF01476.15 EWC48500.1 - 5.2e-08 32.6 0.7 0.011 15.5 0.0 3.8 3 1 0 3 3 3 3 LysM domain SKN1 PF03935.10 EWC48500.1 - 0.00042 18.5 0.2 0.048 11.8 0.1 2.2 1 1 1 2 2 2 2 Beta-glucan synthesis-associated protein (SKN1) Ribosomal_L5_C PF00673.16 EWC48502.1 - 4e-21 74.5 0.0 5.6e-21 74.0 0.0 1.2 1 0 0 1 1 1 1 ribosomal L5P family C-terminus PLDc_2 PF13091.1 EWC48503.1 - 4.8e-15 55.4 0.0 5.3e-07 29.4 0.0 2.3 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.17 EWC48503.1 - 3.6e-07 29.7 4.0 0.044 13.6 0.0 3.2 2 1 0 2 2 2 2 Phospholipase D Active site motif PIP5K PF01504.13 EWC48504.1 - 1.1e-30 106.6 0.0 1.4e-30 106.2 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase PRK PF00485.13 EWC48505.1 - 1.6e-24 86.5 0.0 2e-24 86.2 0.0 1.1 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_17 PF13207.1 EWC48505.1 - 0.00017 22.3 1.0 0.00053 20.7 0.6 1.9 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 EWC48505.1 - 0.0011 19.2 0.1 0.0024 18.1 0.1 1.6 1 1 0 1 1 1 1 AAA domain CoaE PF01121.15 EWC48505.1 - 0.035 13.4 0.5 5 6.4 0.0 2.2 2 0 0 2 2 2 0 Dephospho-CoA kinase DGC PF08859.6 EWC48505.1 - 0.058 13.2 0.3 0.22 11.3 0.0 1.9 2 0 0 2 2 2 0 DGC domain Myotub-related PF06602.9 EWC48507.1 - 9.6e-130 432.4 0.0 1.2e-129 432.1 0.0 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Y_phosphatase3 PF13350.1 EWC48507.1 - 0.0055 16.9 0.0 0.012 15.8 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family DUF3156 PF11354.3 EWC48507.1 - 0.0089 15.4 0.0 0.016 14.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3156) DSPc PF00782.15 EWC48507.1 - 0.029 13.9 0.0 0.061 12.9 0.0 1.5 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 EWC48507.1 - 0.072 12.4 0.0 0.13 11.5 0.0 1.4 1 0 0 1 1 1 0 Protein-tyrosine phosphatase DUF3074 PF11274.3 EWC48508.1 - 2e-50 171.0 0.6 1.1e-49 168.5 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF3074) CAF-1_p150 PF11600.3 EWC48508.1 - 5.7e-05 22.6 34.4 5.7e-05 22.6 23.9 2.0 2 0 0 2 2 2 1 Chromatin assembly factor 1 complex p150 subunit, N-terminal START PF01852.14 EWC48508.1 - 0.03 13.6 0.0 0.31 10.3 0.0 2.2 2 0 0 2 2 2 0 START domain NACHT PF05729.7 EWC48509.1 - 3.4e-21 75.6 0.0 4.9e-21 75.0 0.0 1.2 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.1 EWC48509.1 - 0.0061 16.5 0.0 0.016 15.2 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_19 PF13245.1 EWC48509.1 - 0.017 14.8 0.0 0.038 13.7 0.0 1.6 1 0 0 1 1 1 0 Part of AAA domain AAA_22 PF13401.1 EWC48509.1 - 0.019 15.0 0.0 0.054 13.6 0.0 1.8 1 1 0 1 1 1 0 AAA domain UPF0079 PF02367.12 EWC48509.1 - 0.072 12.7 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 RNA_helicase PF00910.17 EWC48509.1 - 0.08 13.1 0.0 0.19 11.8 0.0 1.7 1 0 0 1 1 1 0 RNA helicase Nab2 PF11517.3 EWC48510.1 - 0.064 13.3 0.0 0.17 11.9 0.0 1.8 1 1 0 1 1 1 0 Nuclear abundant poly(A) RNA-bind protein 2 (Nab2) tRNA-synt_His PF13393.1 EWC48510.1 - 0.086 11.8 0.1 0.13 11.2 0.1 1.4 1 1 0 1 1 1 0 Histidyl-tRNA synthetase Pox_F11 PF04943.7 EWC48510.1 - 0.089 11.6 0.0 0.12 11.2 0.0 1.2 1 0 0 1 1 1 0 Poxvirus F11 protein Syntaxin_2 PF14523.1 EWC48510.1 - 0.13 12.2 0.5 3.3 7.7 0.4 2.2 1 1 0 1 1 1 0 Syntaxin-like protein SQS_PSY PF00494.14 EWC48511.1 - 0.0064 15.8 0.5 0.0064 15.8 0.4 2.2 2 0 0 2 2 2 1 Squalene/phytoene synthase Mcp5_PH PF12814.2 EWC48512.1 - 2.8e-39 133.8 0.1 8.1e-39 132.3 0.0 1.9 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology IMCp PF12314.3 EWC48512.1 - 0.00085 19.4 227.3 0.023 14.8 12.1 8.4 1 1 7 8 8 8 5 Inner membrane complex protein WD40 PF00400.27 EWC48513.1 - 1.3e-09 37.5 12.4 0.15 12.0 0.1 6.9 7 0 0 7 7 7 4 WD domain, G-beta repeat PQQ_3 PF13570.1 EWC48513.1 - 0.16 12.3 4.6 4.8 7.5 0.0 4.1 4 0 0 4 4 4 0 PQQ-like domain SRF-TF PF00319.13 EWC48514.1 - 1.5e-23 81.7 0.2 2.1e-23 81.3 0.2 1.2 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) PAT1 PF09770.4 EWC48514.1 - 0.16 10.1 6.9 0.14 10.3 4.8 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DEAD PF00270.24 EWC48515.1 - 9.1e-37 126.1 0.1 1.5e-36 125.4 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EWC48515.1 - 4.9e-24 83.9 0.0 4.9e-22 77.5 0.0 2.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 EWC48515.1 - 6.9e-07 29.2 0.2 1.6e-06 28.0 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit YihI PF04220.7 EWC48515.1 - 0.062 12.6 0.5 0.21 10.9 0.2 1.9 2 0 0 2 2 2 0 Der GTPase activator (YihI) eIF-1a PF01176.14 EWC48516.1 - 5.2e-29 99.4 0.1 7.5e-29 98.9 0.1 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 Ank_2 PF12796.2 EWC48518.1 - 3.7e-24 84.8 0.2 1.2e-13 51.2 0.8 2.8 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 EWC48518.1 - 3.7e-17 61.9 1.8 6.5e-06 26.2 0.2 4.8 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.25 EWC48518.1 - 4e-15 54.7 5.0 0.00039 20.0 0.1 5.1 4 0 0 4 4 4 4 Ankyrin repeat Ank_4 PF13637.1 EWC48518.1 - 8e-12 45.3 1.6 0.0055 17.1 0.1 5.0 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 EWC48518.1 - 4.2e-10 38.8 0.5 0.34 11.2 0.0 6.1 6 0 0 6 6 6 2 Ankyrin repeat Ferric_reduct PF01794.14 EWC48519.1 - 2.6e-12 46.8 13.9 2.6e-12 46.8 9.6 1.9 2 0 0 2 2 2 1 Ferric reductase like transmembrane component Ribosomal_L7Ae PF01248.21 EWC48521.1 - 1.8e-27 94.6 0.8 2.7e-27 94.0 0.6 1.3 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Steroid_dh PF02544.11 EWC48521.1 - 1.1e-09 38.2 0.2 1.6e-09 37.7 0.2 1.3 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase IU_nuc_hydro PF01156.14 EWC48522.1 - 4.2e-43 147.7 0.0 5.2e-43 147.4 0.0 1.1 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase CENP-B_dimeris PF09026.5 EWC48524.1 - 0.24 11.6 15.6 1.4 9.2 9.1 3.0 3 0 0 3 3 3 0 Centromere protein B dimerisation domain DUF883 PF05957.8 EWC48524.1 - 1.6 9.1 8.9 0.92 9.9 1.8 2.6 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) DUF3810 PF12725.2 EWC48524.1 - 3.2 6.5 6.4 21 3.8 0.0 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3810) Ran_BP1 PF00638.13 EWC48525.1 - 3.2e-50 169.2 4.1 4.6e-50 168.7 2.8 1.2 1 0 0 1 1 1 1 RanBP1 domain WH1 PF00568.18 EWC48525.1 - 2.1e-05 24.1 1.0 9.7e-05 22.0 0.7 1.9 1 1 0 1 1 1 1 WH1 domain VID27 PF08553.5 EWC48525.1 - 6.2e-05 21.4 6.3 0.0001 20.7 4.4 1.3 1 1 0 1 1 1 1 VID27 cytoplasmic protein DUF1681 PF07933.9 EWC48525.1 - 0.003 17.1 0.2 0.0076 15.8 0.2 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1681) YEATS PF03366.11 EWC48526.1 - 3.9e-26 90.5 0.3 6.6e-26 89.8 0.2 1.4 1 0 0 1 1 1 1 YEATS family Aminotran_1_2 PF00155.16 EWC48527.1 - 4.6e-61 206.7 0.0 6e-61 206.3 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 EWC48527.1 - 0.00024 20.3 0.0 0.00036 19.7 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.14 EWC48527.1 - 0.018 13.7 0.0 0.029 13.1 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.12 EWC48527.1 - 0.16 11.0 0.0 0.24 10.3 0.0 1.2 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family OKR_DC_1 PF01276.15 EWC48527.1 - 0.16 10.4 0.0 0.4 9.1 0.0 1.6 1 1 0 1 1 1 0 Orn/Lys/Arg decarboxylase, major domain Peptidase_M16_C PF05193.16 EWC48528.1 - 4.3e-43 147.1 0.0 1.5e-42 145.3 0.0 1.9 1 1 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.15 EWC48528.1 - 2.9e-41 140.6 0.0 9.6e-41 139.0 0.0 1.8 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) SNF2_N PF00176.18 EWC48529.1 - 5.9e-70 235.4 0.0 8.5e-70 234.9 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain HIRAN PF08797.6 EWC48529.1 - 1.5e-21 76.2 0.0 3.4e-21 75.1 0.0 1.6 1 0 0 1 1 1 1 HIRAN domain Helicase_C PF00271.26 EWC48529.1 - 3.4e-13 49.2 0.0 8.3e-13 48.0 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-C3HC4_2 PF13923.1 EWC48529.1 - 4.9e-07 29.6 8.5 8.9e-07 28.8 5.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 EWC48529.1 - 6.4e-07 28.9 7.8 1.1e-06 28.2 5.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EWC48529.1 - 1.2e-05 25.0 7.6 2.2e-05 24.1 5.3 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 EWC48529.1 - 7.1e-05 22.3 9.7 0.00013 21.5 6.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EWC48529.1 - 0.0001 21.9 8.5 0.0002 20.9 5.9 1.6 1 0 0 1 1 1 1 zinc-RING finger domain ResIII PF04851.10 EWC48529.1 - 0.00012 22.0 0.0 0.00037 20.3 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit UBA_4 PF14555.1 EWC48529.1 - 0.011 15.2 0.3 0.042 13.3 0.0 2.2 2 0 0 2 2 2 0 UBA-like domain AAA_22 PF13401.1 EWC48529.1 - 0.035 14.2 0.0 0.85 9.7 0.0 3.1 2 1 0 2 2 2 0 AAA domain zf-RING_4 PF14570.1 EWC48529.1 - 0.28 10.8 10.3 8.1 6.1 6.9 2.4 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.1 EWC48529.1 - 0.34 10.8 7.2 0.67 9.8 5.0 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 EWC48529.1 - 0.65 9.7 7.3 1.8 8.3 5.1 1.8 1 0 0 1 1 1 0 RING-type zinc-finger DUF4112 PF13430.1 EWC48530.1 - 1.3e-34 118.2 0.4 1.7e-34 117.9 0.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4112) DCP2 PF05026.8 EWC48531.1 - 2.6e-28 97.7 0.1 4.3e-28 97.0 0.1 1.4 1 0 0 1 1 1 1 Dcp2, box A domain NUDIX PF00293.23 EWC48531.1 - 2.5e-16 59.5 0.1 4.9e-16 58.5 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain L51_S25_CI-B8 PF05047.11 EWC48532.1 - 1.2e-14 53.7 0.1 1.9e-14 53.0 0.1 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain Phosducin PF02114.11 EWC48533.1 - 2.8e-18 65.6 0.2 1.3e-15 56.8 0.0 2.4 3 0 0 3 3 3 2 Phosducin Na_Ca_ex PF01699.19 EWC48534.1 - 1.6e-27 95.8 23.2 1.1e-19 70.4 5.6 2.6 2 1 1 3 3 3 3 Sodium/calcium exchanger protein MtrG PF04210.8 EWC48534.1 - 0.21 11.2 0.8 0.85 9.3 0.0 2.3 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, subunit G DUF165 PF02592.10 EWC48534.1 - 6.3 6.9 14.2 0.051 13.7 0.8 3.2 3 2 1 4 4 4 0 Uncharacterized ACR, YhhQ family COG1738 WD40 PF00400.27 EWC48535.1 - 3.3e-52 172.6 19.8 7.5e-09 35.1 0.0 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat eIF2A PF08662.6 EWC48535.1 - 0.00029 20.6 0.0 0.28 10.8 0.0 2.8 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.11 EWC48535.1 - 0.047 11.9 0.0 0.28 9.4 0.0 1.9 2 0 0 2 2 2 0 Cytochrome D1 heme domain Nup160 PF11715.3 EWC48535.1 - 0.077 11.1 0.1 2.5 6.1 0.1 2.3 1 1 0 2 2 2 0 Nucleoporin Nup120/160 A_deaminase PF00962.17 EWC48536.1 - 2e-23 82.8 0.0 2.6e-23 82.4 0.0 1.1 1 0 0 1 1 1 1 Adenosine/AMP deaminase DUF3722 PF12519.3 EWC48537.1 - 4.4e-89 298.1 0.3 5.5e-89 297.8 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3722) Porin_3 PF01459.17 EWC48537.1 - 0.00053 19.3 0.0 0.013 14.8 0.0 2.7 2 1 0 2 2 2 1 Eukaryotic porin Ribosomal_L10 PF00466.15 EWC48538.1 - 3.9e-16 58.8 0.0 5.3e-16 58.3 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L10 DUF1500 PF07389.7 EWC48538.1 - 0.062 13.3 0.1 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1500) Terminase_1 PF03354.10 EWC48538.1 - 0.12 10.7 0.0 0.17 10.2 0.0 1.2 1 0 0 1 1 1 0 Phage Terminase TIM PF00121.13 EWC48539.1 - 1.9e-83 279.2 0.0 2.1e-83 279.1 0.0 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase Bestrophin PF01062.16 EWC48540.1 - 1.1e-49 168.9 0.0 1.7e-49 168.3 0.0 1.2 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel Aminotran_4 PF01063.14 EWC48541.1 - 1.2e-23 83.7 0.0 1.6e-23 83.3 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class IV Mito_fiss_reg PF05308.6 EWC48541.1 - 0.02 14.2 1.9 0.028 13.7 1.4 1.1 1 0 0 1 1 1 0 Mitochondrial fission regulator TMEM171 PF15471.1 EWC48541.1 - 0.68 8.6 5.4 1.1 7.9 3.7 1.3 1 0 0 1 1 1 0 Transmembrane protein family 171 AMP-binding PF00501.23 EWC48542.1 - 1.7e-43 148.5 0.0 2.2e-43 148.1 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 EWC48542.1 - 0.0035 18.2 0.0 0.013 16.4 0.0 2.0 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain FHA PF00498.21 EWC48543.1 - 1.1e-16 60.6 0.1 1.7e-16 60.0 0.0 1.3 1 0 0 1 1 1 1 FHA domain zf-RING_2 PF13639.1 EWC48543.1 - 9e-08 31.8 8.3 1.4e-07 31.2 5.7 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 EWC48543.1 - 0.00074 19.5 3.0 0.0014 18.7 2.1 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger zf-Apc11 PF12861.2 EWC48543.1 - 0.0019 17.9 1.5 0.0047 16.7 1.0 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4 PF00097.20 EWC48543.1 - 0.0021 17.6 9.7 0.0034 17.0 6.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EWC48543.1 - 0.063 13.0 6.3 0.11 12.2 4.4 1.4 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_2 PF13923.1 EWC48543.1 - 0.083 12.9 11.3 0.14 12.2 7.9 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING-like PF08746.6 EWC48543.1 - 1.9 8.5 5.6 3.2 7.8 3.9 1.4 1 0 0 1 1 1 0 RING-like domain COMPASS-Shg1 PF05205.7 EWC48544.1 - 4.5e-11 42.9 0.1 1.3e-10 41.5 0.1 1.7 1 1 0 1 1 1 1 COMPASS (Complex proteins associated with Set1p) component shg1 ATP13 PF12921.2 EWC48545.1 - 1.4e-16 60.0 0.0 2.8e-16 59.0 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial ATPase expression PPR_2 PF13041.1 EWC48545.1 - 2.3e-08 33.8 1.1 0.16 11.9 0.0 4.3 4 0 0 4 4 4 3 PPR repeat family PPR_3 PF13812.1 EWC48545.1 - 0.00011 22.2 3.2 56 4.3 0.1 6.5 6 1 1 7 7 7 0 Pentatricopeptide repeat domain PPR_1 PF12854.2 EWC48545.1 - 0.16 11.5 0.3 5.3 6.6 0.1 2.8 2 0 0 2 2 2 0 PPR repeat PIG-L PF02585.12 EWC48546.1 - 9e-15 55.3 0.0 1.3e-14 54.8 0.0 1.2 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase DUF3671 PF12420.3 EWC48547.1 - 0.1 12.6 0.3 0.31 11.0 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function DUF2919 PF11143.3 EWC48547.1 - 0.11 12.3 2.9 0.27 11.0 0.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2919) DUF4131 PF13567.1 EWC48547.1 - 0.74 9.1 3.8 7.8 5.8 2.3 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4131) DUF4501 PF14946.1 EWC48548.1 - 0.064 12.7 0.0 0.29 10.5 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4501) DUF3188 PF11384.3 EWC48548.1 - 0.32 10.5 1.2 0.58 9.7 0.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3188) Arrestin_C PF02752.17 EWC48549.1 - 7.7e-26 90.8 0.0 8.4e-24 84.2 0.0 2.4 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.24 EWC48549.1 - 4.5e-10 39.5 0.0 0.00013 21.8 0.0 2.5 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain PTCB-BRCT PF12738.2 EWC48550.1 - 7.4e-41 137.8 0.4 1.9e-20 72.4 0.0 4.4 4 0 0 4 4 4 4 twin BRCT domain BRCT PF00533.21 EWC48550.1 - 5.4e-38 129.0 0.4 1.7e-14 53.6 0.0 5.4 5 0 0 5 5 5 5 BRCA1 C Terminus (BRCT) domain Pro-MCH PF05824.7 EWC48550.1 - 0.061 12.8 0.0 0.17 11.3 0.0 1.7 1 0 0 1 1 1 0 Pro-melanin-concentrating hormone (Pro-MCH) DUF3785 PF12653.2 EWC48550.1 - 0.27 11.0 0.0 0.54 10.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3785) Cullin PF00888.17 EWC48551.1 - 2.6e-126 422.5 0.1 3.2e-126 422.2 0.1 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.4 EWC48551.1 - 1.8e-25 88.5 1.9 4.9e-25 87.1 1.3 1.8 1 0 0 1 1 1 1 Cullin protein neddylation domain NAD_kinase PF01513.16 EWC48552.1 - 2.4e-69 233.2 0.0 3.6e-69 232.7 0.0 1.2 1 0 0 1 1 1 1 ATP-NAD kinase Lactamase_B PF00753.22 EWC48552.1 - 4.3e-28 98.3 2.5 7.4e-28 97.5 1.7 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 EWC48552.1 - 7e-06 25.7 0.2 1.3e-05 24.7 0.1 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain BcrAD_BadFG PF01869.15 EWC48552.1 - 0.0077 15.5 0.0 0.044 13.0 0.0 2.2 3 0 0 3 3 3 1 BadF/BadG/BcrA/BcrD ATPase family Erp_C PF06780.6 EWC48552.1 - 0.02 14.7 0.5 0.25 11.2 0.3 2.3 2 0 0 2 2 2 0 Erp protein C-terminus Ead_Ea22 PF13935.1 EWC48552.1 - 0.039 14.2 0.5 0.16 12.2 0.0 2.2 3 0 0 3 3 3 0 Ead/Ea22-like protein Las1 PF04031.8 EWC48553.1 - 9.1e-49 165.0 0.2 4.6e-48 162.7 0.0 2.0 2 0 0 2 2 2 1 Las1-like MIS13 PF08202.6 EWC48553.1 - 0.047 12.7 0.1 0.081 11.9 0.1 1.4 1 0 0 1 1 1 0 Mis12-Mtw1 protein family IF4E PF01652.13 EWC48554.1 - 1.4e-39 135.2 0.5 2.2e-39 134.6 0.3 1.3 1 1 0 1 1 1 1 Eukaryotic initiation factor 4E GDA1_CD39 PF01150.12 EWC48555.1 - 1.2e-99 333.7 0.0 1.4e-99 333.5 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Peptidase_C97 PF05903.9 EWC48556.1 - 2.2e-33 115.1 0.0 3.5e-33 114.5 0.0 1.3 1 0 0 1 1 1 1 PPPDE putative peptidase domain PUL PF08324.6 EWC48556.1 - 3.8e-28 98.0 0.0 4.8e-28 97.6 0.0 1.1 1 0 0 1 1 1 1 PUL domain Thioredoxin PF00085.15 EWC48556.1 - 5.5e-17 61.3 0.0 1e-16 60.5 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.1 EWC48556.1 - 8.5e-05 22.7 0.0 0.00032 20.8 0.0 1.9 1 1 0 1 1 1 1 Thioredoxin-like domain DUF2847 PF11009.3 EWC48556.1 - 0.00045 19.7 0.0 0.00099 18.6 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2847) Thioredoxin_3 PF13192.1 EWC48556.1 - 0.00068 19.3 0.0 0.0021 17.8 0.0 1.8 1 0 0 1 1 1 1 Thioredoxin domain Thioredoxin_4 PF13462.1 EWC48556.1 - 0.0061 16.5 0.1 0.036 14.0 0.0 2.0 1 1 1 2 2 2 1 Thioredoxin Redoxin PF08534.5 EWC48556.1 - 0.011 15.2 0.0 0.022 14.3 0.0 1.4 1 0 0 1 1 1 0 Redoxin AhpC-TSA PF00578.16 EWC48556.1 - 0.011 15.3 0.0 0.022 14.4 0.0 1.4 1 0 0 1 1 1 0 AhpC/TSA family Thioredoxin_8 PF13905.1 EWC48556.1 - 0.035 14.2 0.0 0.08 13.0 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin-like TraF PF13728.1 EWC48556.1 - 0.04 13.4 0.0 0.063 12.7 0.0 1.2 1 0 0 1 1 1 0 F plasmid transfer operon protein Thioredoxin_7 PF13899.1 EWC48556.1 - 0.061 13.3 0.0 0.15 12.1 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin-like T4_deiodinase PF00837.12 EWC48556.1 - 0.083 11.8 0.0 0.14 11.1 0.0 1.3 1 0 0 1 1 1 0 Iodothyronine deiodinase SpoU_methylase PF00588.14 EWC48557.1 - 8.5e-27 93.7 0.0 1.5e-26 92.9 0.0 1.4 1 0 0 1 1 1 1 SpoU rRNA Methylase family UDG PF03167.14 EWC48559.1 - 4e-17 62.0 0.0 5.8e-17 61.5 0.0 1.2 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily Kinesin PF00225.18 EWC48560.1 - 5.8e-112 373.6 0.1 5.8e-112 373.6 0.1 1.6 2 0 0 2 2 2 1 Kinesin motor domain TPR_MLP1_2 PF07926.7 EWC48560.1 - 0.00027 20.7 13.7 0.00063 19.4 9.5 1.6 1 0 0 1 1 1 1 TPR/MLP1/MLP2-like protein V_ATPase_I PF01496.14 EWC48560.1 - 0.0019 16.1 5.3 0.003 15.5 3.2 1.5 2 0 0 2 2 2 1 V-type ATPase 116kDa subunit family DUF3450 PF11932.3 EWC48560.1 - 0.15 11.2 11.9 0.35 10.0 8.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) PilJ PF13675.1 EWC48560.1 - 0.17 12.1 9.6 3.3 8.0 4.3 3.1 3 1 0 3 3 3 0 Type IV pili methyl-accepting chemotaxis transducer N-term ERM PF00769.14 EWC48560.1 - 0.2 11.1 16.0 0.41 10.1 11.1 1.4 1 0 0 1 1 1 0 Ezrin/radixin/moesin family Mnd1 PF03962.10 EWC48560.1 - 0.21 11.2 12.1 0.46 10.1 8.4 1.5 1 0 0 1 1 1 0 Mnd1 family Atg14 PF10186.4 EWC48560.1 - 9.5 5.0 15.7 4.1 6.2 9.3 1.6 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 IncA PF04156.9 EWC48560.1 - 9.8 5.7 13.6 20 4.7 9.4 1.5 1 0 0 1 1 1 0 IncA protein Vps16_N PF04841.8 EWC48561.1 - 4.5e-93 311.9 0.0 6.6e-93 311.4 0.0 1.2 1 0 0 1 1 1 1 Vps16, N-terminal region Vps16_C PF04840.7 EWC48561.1 - 1.7e-86 290.0 0.0 2.5e-86 289.5 0.0 1.2 1 0 0 1 1 1 1 Vps16, C-terminal region Fungal_trans PF04082.13 EWC48562.1 - 8.4e-21 73.9 3.0 1.4e-20 73.2 2.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF3486 PF11985.3 EWC48562.1 - 0.089 12.8 1.3 3.6 7.6 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3486) RasGEF PF00617.14 EWC48563.1 - 8.2e-63 211.5 0.0 1.4e-62 210.8 0.0 1.3 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.15 EWC48563.1 - 3.7e-25 88.0 0.3 7.1e-25 87.1 0.2 1.5 1 0 0 1 1 1 1 RasGEF N-terminal motif SH3_1 PF00018.23 EWC48563.1 - 4.7e-16 57.9 0.1 8.9e-16 57.0 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 EWC48563.1 - 8.2e-15 54.1 0.1 1.8e-14 53.0 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 EWC48563.1 - 3e-13 49.0 0.0 5.9e-13 48.0 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain WW PF00397.21 EWC48563.1 - 0.0014 18.4 0.0 0.0032 17.2 0.0 1.6 1 0 0 1 1 1 1 WW domain Amidohydro_1 PF01979.15 EWC48564.1 - 1.5e-31 110.3 0.1 1.8e-31 110.0 0.1 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_5 PF13594.1 EWC48564.1 - 2.9e-05 23.8 0.1 8.7e-05 22.2 0.0 1.9 2 0 0 2 2 2 1 Amidohydrolase Amidohydro_4 PF13147.1 EWC48564.1 - 0.0024 17.9 8.8 0.14 12.2 6.1 3.7 1 1 0 1 1 1 1 Amidohydrolase Amidohydro_3 PF07969.6 EWC48564.1 - 0.0068 15.6 1.0 1.6 7.8 0.1 2.6 3 0 0 3 3 3 2 Amidohydrolase family DUF1907 PF08925.6 EWC48564.1 - 0.11 11.6 0.0 0.16 11.0 0.0 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1907) GFO_IDH_MocA PF01408.17 EWC48565.1 - 3.4e-15 56.6 0.0 6.1e-15 55.8 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.12 EWC48565.1 - 0.011 15.5 0.0 0.072 12.8 0.0 2.1 1 1 1 2 2 2 0 Oxidoreductase family, C-terminal alpha/beta domain DNMT1-RFD PF12047.3 EWC48567.1 - 2.7e-06 27.1 0.0 5.4e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 Cytosine specific DNA methyltransferase replication foci domain RBFA PF02033.13 EWC48567.1 - 0.12 12.4 0.0 0.54 10.3 0.0 2.1 2 0 0 2 2 2 0 Ribosome-binding factor A Ebp2 PF05890.7 EWC48568.1 - 4.4e-83 278.7 9.5 4.4e-83 278.7 6.6 2.4 2 1 0 2 2 2 1 Eukaryotic rRNA processing protein EBP2 BUD22 PF09073.5 EWC48568.1 - 0.0032 16.5 30.5 0.0032 16.5 21.1 2.4 2 1 0 2 2 2 1 BUD22 Tom22 PF04281.8 EWC48571.1 - 2.4e-43 146.9 1.3 8.7e-43 145.1 0.9 1.7 1 1 0 1 1 1 1 Mitochondrial import receptor subunit Tom22 DAO PF01266.19 EWC48571.1 - 0.054 12.3 0.0 0.071 11.9 0.0 1.1 1 0 0 1 1 1 0 FAD dependent oxidoreductase Thioredoxin PF00085.15 EWC48572.1 - 2.7e-57 190.8 0.4 7.4e-29 99.5 0.0 2.3 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_2 PF13098.1 EWC48572.1 - 4.7e-16 58.9 0.2 1.8e-06 28.0 0.0 3.0 2 1 0 2 2 2 2 Thioredoxin-like domain ERp29 PF07749.7 EWC48572.1 - 2e-14 53.9 1.4 3e-14 53.4 0.4 1.7 2 0 0 2 2 1 1 Endoplasmic reticulum protein ERp29, C-terminal domain Thioredoxin_7 PF13899.1 EWC48572.1 - 1.1e-12 47.7 0.0 5.5e-06 26.3 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin-like Thioredoxin_8 PF13905.1 EWC48572.1 - 3.9e-12 46.1 0.7 0.00028 20.9 0.0 4.0 4 2 1 5 5 3 2 Thioredoxin-like AhpC-TSA PF00578.16 EWC48572.1 - 1.2e-10 41.1 0.2 0.00019 21.0 0.0 2.3 2 0 0 2 2 2 2 AhpC/TSA family Redoxin PF08534.5 EWC48572.1 - 4.9e-09 35.8 1.4 0.0018 17.8 0.2 2.3 2 0 0 2 2 2 2 Redoxin ERp29_N PF07912.8 EWC48572.1 - 2e-06 27.7 0.2 0.0013 18.6 0.0 2.4 2 0 0 2 2 2 2 ERp29, N-terminal domain Thioredoxin_6 PF13848.1 EWC48572.1 - 3.9e-05 23.5 0.1 0.34 10.6 0.0 3.4 2 2 1 3 3 3 2 Thioredoxin-like domain Thioredoxin_9 PF14595.1 EWC48572.1 - 0.00043 19.8 0.0 0.18 11.3 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin Glutaredoxin PF00462.19 EWC48572.1 - 0.055 13.4 0.3 16 5.5 0.0 2.9 2 0 0 2 2 2 0 Glutaredoxin Mt_ATP-synt_D PF05873.7 EWC48572.1 - 0.061 12.9 0.0 0.13 11.8 0.0 1.5 1 0 0 1 1 1 0 ATP synthase D chain, mitochondrial (ATP5H) TraF PF13728.1 EWC48572.1 - 0.098 12.1 0.0 1.5 8.2 0.0 2.2 2 0 0 2 2 2 0 F plasmid transfer operon protein Thioredoxin_4 PF13462.1 EWC48572.1 - 0.15 12.0 2.4 13 5.7 0.0 3.0 3 1 0 3 3 3 0 Thioredoxin HSBP1 PF06825.7 EWC48573.1 - 4.4e-08 32.5 0.1 6.2e-08 32.0 0.0 1.3 1 0 0 1 1 1 1 Heat shock factor binding protein 1 BLOC1_2 PF10046.4 EWC48573.1 - 0.00031 20.8 0.1 0.00044 20.3 0.0 1.3 1 1 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 CCD PF07860.6 EWC48573.1 - 0.0048 16.3 0.1 0.007 15.8 0.1 1.3 1 0 0 1 1 1 1 WisP family C-Terminal Region HsbA PF12296.3 EWC48573.1 - 0.014 15.2 1.0 0.017 14.9 0.7 1.2 1 0 0 1 1 1 0 Hydrophobic surface binding protein A Baculo_PEP_C PF04513.7 EWC48573.1 - 0.02 14.7 0.1 0.025 14.4 0.1 1.1 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus SPX PF03105.14 EWC48573.1 - 0.024 14.4 0.4 0.027 14.2 0.3 1.0 1 0 0 1 1 1 0 SPX domain FUSC-like PF12805.2 EWC48573.1 - 0.025 13.5 0.0 0.031 13.1 0.0 1.1 1 0 0 1 1 1 0 FUSC-like inner membrane protein yccS UPF0184 PF03670.8 EWC48573.1 - 0.037 14.1 0.9 3.3 7.9 0.0 2.4 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0184) Med11 PF10280.4 EWC48573.1 - 0.044 13.8 0.6 0.054 13.5 0.4 1.4 1 1 0 1 1 1 0 Mediator complex protein Hemagglutinin PF00509.13 EWC48573.1 - 0.071 11.2 0.0 0.079 11.0 0.0 1.1 1 0 0 1 1 1 0 Haemagglutinin DivIVA PF05103.8 EWC48573.1 - 0.086 12.8 0.1 0.12 12.4 0.1 1.2 1 0 0 1 1 1 0 DivIVA protein FlxA PF14282.1 EWC48573.1 - 0.089 12.7 2.4 0.18 11.7 1.6 1.7 1 1 0 1 1 1 0 FlxA-like protein CAP_N PF01213.14 EWC48573.1 - 0.11 11.6 1.4 0.79 8.9 0.1 1.9 1 1 1 2 2 2 0 Adenylate cyclase associated (CAP) N terminal Syntaxin PF00804.20 EWC48573.1 - 0.17 12.0 1.0 0.59 10.3 0.7 1.8 1 1 0 1 1 1 0 Syntaxin Erythro-docking PF09277.6 EWC48573.1 - 0.22 11.2 1.1 0.33 10.6 0.1 1.7 2 1 1 3 3 2 0 Erythronolide synthase, docking DUF4449 PF14613.1 EWC48575.1 - 7e-57 191.9 6.4 7e-57 191.9 4.4 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF4449) GCV_T PF01571.16 EWC48576.1 - 2.2e-06 27.2 0.0 9.2e-06 25.1 0.0 2.0 1 1 0 1 1 1 1 Aminomethyltransferase folate-binding domain DnaJ PF00226.26 EWC48577.1 - 9.9e-21 73.2 0.3 2.6e-20 71.9 0.2 1.8 1 0 0 1 1 1 1 DnaJ domain RRM_1 PF00076.17 EWC48577.1 - 0.049 13.2 0.0 0.1 12.2 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Selenoprotein_S PF06936.6 EWC48577.1 - 2.3 7.6 13.1 0.25 10.8 3.4 2.3 2 0 0 2 2 2 0 Selenoprotein S (SelS) Ribosomal_L18e PF00828.14 EWC48578.1 - 1.6e-15 57.6 0.2 2.9e-15 56.7 0.2 1.4 1 0 0 1 1 1 1 Ribosomal protein L18e/L15 UPF0542 PF15086.1 EWC48578.1 - 0.069 12.8 1.1 0.13 11.9 0.8 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0542 LSM PF01423.17 EWC48579.1 - 2.2e-15 55.9 0.6 3.3e-15 55.3 0.4 1.3 1 1 0 1 1 1 1 LSM domain DUF2272 PF10030.4 EWC48579.1 - 0.11 11.9 0.0 0.11 11.9 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2272) Porphobil_deam PF01379.15 EWC48581.1 - 9e-81 269.8 0.0 1.1e-80 269.5 0.0 1.1 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.10 EWC48581.1 - 1e-15 57.5 0.4 2.4e-15 56.3 0.3 1.7 1 0 0 1 1 1 1 Porphobilinogen deaminase, C-terminal domain CBS PF00571.23 EWC48582.1 - 1e-25 89.1 7.3 2e-13 49.8 0.3 4.3 4 0 0 4 4 4 4 CBS domain IL32 PF15225.1 EWC48582.1 - 0.06 13.3 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 Interleukin 32 vWA-TerF-like PF10138.4 EWC48583.1 - 7.1e-07 29.2 0.1 1.1e-06 28.6 0.0 1.2 1 0 0 1 1 1 1 vWA found in TerF C terminus VWA_2 PF13519.1 EWC48583.1 - 0.03 14.4 0.3 0.074 13.1 0.2 1.6 1 1 0 1 1 1 0 von Willebrand factor type A domain Arm PF00514.18 EWC48585.1 - 4.8e-70 229.2 34.2 1.7e-12 46.6 0.0 11.4 11 1 1 12 12 12 9 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 EWC48585.1 - 4.1e-24 84.6 12.8 3.1e-07 30.5 0.1 7.4 3 2 3 6 6 6 5 HEAT repeats HEAT PF02985.17 EWC48585.1 - 4.5e-18 63.6 16.1 0.017 15.1 0.0 9.2 10 0 0 10 10 10 5 HEAT repeat HEAT_EZ PF13513.1 EWC48585.1 - 5.7e-16 58.4 16.7 0.00011 22.5 0.0 8.4 6 3 3 9 9 9 5 HEAT-like repeat Arm_2 PF04826.8 EWC48585.1 - 2.9e-12 46.2 5.7 0.00033 19.8 0.1 3.3 2 1 1 3 3 3 3 Armadillo-like Adaptin_N PF01602.15 EWC48585.1 - 4e-12 45.2 8.5 3.5e-08 32.2 0.1 3.3 1 1 1 2 2 2 2 Adaptin N terminal region KAP PF05804.7 EWC48585.1 - 1.4e-09 36.4 0.2 2.4e-09 35.7 0.1 1.3 1 0 0 1 1 1 1 Kinesin-associated protein (KAP) V-ATPase_H_N PF03224.9 EWC48585.1 - 5.1e-09 35.6 2.0 0.0079 15.3 0.3 3.9 2 1 1 3 3 3 2 V-ATPase subunit H HEAT_PBS PF03130.11 EWC48585.1 - 0.0014 18.9 5.1 6.1 7.6 0.2 6.6 6 0 0 6 6 6 1 PBS lyase HEAT-like repeat PUL PF08324.6 EWC48585.1 - 0.0063 15.3 0.5 0.029 13.1 0.2 2.2 2 0 0 2 2 2 1 PUL domain DUF2454 PF10521.4 EWC48585.1 - 0.011 14.7 0.7 0.054 12.4 0.1 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2454) Vac14_Fab1_bd PF12755.2 EWC48585.1 - 0.023 15.0 0.1 0.99 9.8 0.0 3.2 1 1 2 3 3 3 0 Vacuolar 14 Fab1-binding region Vpu PF00558.14 EWC48585.1 - 0.071 12.6 0.3 0.071 12.6 0.2 2.0 2 0 0 2 2 2 0 Vpu protein DUF1981 PF09324.5 EWC48585.1 - 0.11 12.0 0.1 15 5.2 0.0 3.6 4 0 0 4 4 4 0 Domain of unknown function (DUF1981) UPF0052 PF01933.13 EWC48586.1 - 4.1e-51 174.1 0.0 6e-51 173.5 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family UPF0052 DUF1501 PF07394.7 EWC48586.1 - 0.15 10.9 0.0 0.22 10.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) Apc13p PF05839.6 EWC48587.1 - 3.9e-28 97.2 0.4 4.9e-28 96.9 0.3 1.0 1 0 0 1 1 1 1 Apc13p protein Ribosomal_S14 PF00253.16 EWC48588.1 - 1.2e-17 62.9 4.6 1.3e-17 62.8 3.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e DUF1451 PF07295.6 EWC48588.1 - 0.13 12.0 0.2 0.13 11.9 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1451) Prim_Zn_Ribbon PF08273.7 EWC48588.1 - 0.71 10.0 4.3 4.8 7.3 0.2 2.1 1 1 1 2 2 2 0 Zinc-binding domain of primase-helicase Pro_isomerase PF00160.16 EWC48589.1 - 6.5e-48 162.8 0.1 1.3e-47 161.9 0.0 1.5 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Rtf2 PF04641.7 EWC48589.1 - 3.1e-05 23.3 0.0 0.00073 18.8 0.0 2.3 2 0 0 2 2 2 1 Rtf2 RING-finger Chs3p PF12271.3 EWC48590.1 - 4.8e-135 449.1 18.8 6e-135 448.9 13.0 1.0 1 0 0 1 1 1 1 Chitin synthase III catalytic subunit Prp19_bind PF06991.6 EWC48591.1 - 2e-29 102.7 2.6 5.5e-26 91.4 0.1 3.9 1 1 2 4 4 4 2 Splicing factor, Prp19-binding domain DUF605 PF04652.11 EWC48591.1 - 0.14 11.5 18.8 0.2 11.0 13.0 1.1 1 0 0 1 1 1 0 Vta1 like Ndc1_Nup PF09531.5 EWC48591.1 - 2.1 6.6 4.0 2.7 6.2 2.8 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup TRAPP PF04051.11 EWC48592.1 - 5.1e-40 136.4 0.0 6.2e-40 136.1 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component NDUF_C2 PF06374.6 EWC48593.1 - 0.014 15.4 0.0 0.02 14.9 0.0 1.2 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2) Vert_HS_TF PF06546.6 EWC48593.1 - 0.086 12.2 0.1 0.11 11.8 0.1 1.1 1 0 0 1 1 1 0 Vertebrate heat shock transcription factor Glyco_transf_90 PF05686.7 EWC48594.1 - 5.2e-14 51.7 6.2 2e-12 46.5 1.4 3.8 2 1 0 2 2 2 2 Glycosyl transferase family 90 Alb1 PF09135.6 EWC48595.1 - 3.7e-09 37.1 8.8 7.9e-09 36.1 6.1 1.5 1 1 0 1 1 1 1 Alb1 UCH PF00443.24 EWC48596.1 - 2.1e-09 36.8 0.0 3.1e-08 33.0 0.0 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH PF00443.24 EWC48597.1 - 2e-11 43.5 0.0 3.1e-10 39.6 0.0 2.0 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 EWC48597.1 - 0.012 15.1 0.0 0.03 13.7 0.0 1.9 1 1 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase PP2C PF00481.16 EWC48598.1 - 6.8e-65 218.9 0.1 6.1e-51 173.2 0.0 3.1 3 0 0 3 3 3 3 Protein phosphatase 2C 4HBT_3 PF13622.1 EWC48599.1 - 1.1e-13 51.4 0.8 4.8e-13 49.4 0.2 1.8 1 1 1 2 2 2 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.10 EWC48599.1 - 3.6e-07 29.8 0.0 1.3e-05 24.8 0.0 2.7 2 1 0 2 2 2 1 Acyl-CoA thioesterase Nup160 PF11715.3 EWC48599.1 - 0.069 11.2 0.0 0.081 11.0 0.0 1.1 1 0 0 1 1 1 0 Nucleoporin Nup120/160 Cyclin PF08613.6 EWC48600.1 - 3.5e-17 63.2 0.0 6.2e-17 62.3 0.0 1.5 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.18 EWC48600.1 - 0.0041 16.6 0.2 0.0072 15.8 0.1 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain PGAP1 PF07819.8 EWC48601.1 - 0.0021 17.6 0.0 0.0035 16.9 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_6 PF12697.2 EWC48601.1 - 1.9 8.2 7.3 0.54 10.0 0.3 2.3 1 1 0 2 2 2 0 Alpha/beta hydrolase family GCV_H PF01597.14 EWC48602.1 - 1.7e-39 134.2 0.4 2.1e-39 133.9 0.3 1.1 1 0 0 1 1 1 1 Glycine cleavage H-protein Biotin_lipoyl PF00364.17 EWC48602.1 - 0.0008 18.9 0.4 0.0015 18.1 0.2 1.3 1 0 0 1 1 1 1 Biotin-requiring enzyme RnfC_N PF13375.1 EWC48602.1 - 0.033 13.8 0.1 0.06 13.0 0.1 1.3 1 0 0 1 1 1 0 RnfC Barrel sandwich hybrid domain Ribosomal_S6 PF01250.12 EWC48603.1 - 1.3e-07 31.3 0.0 1.6e-07 31.1 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S6 RRM_1 PF00076.17 EWC48604.1 - 6.9e-59 195.3 0.0 2.8e-21 74.8 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EWC48604.1 - 3.7e-38 129.3 0.0 1.7e-13 50.3 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EWC48604.1 - 9.5e-30 102.2 0.0 4.5e-10 39.2 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 EWC48604.1 - 2.5e-07 30.3 0.1 0.25 11.1 0.0 3.6 3 1 0 3 3 3 3 Nup53/35/40-type RNA recognition motif Cas_Cas2CT1978 PF09707.5 EWC48604.1 - 0.0012 18.7 0.0 1.7 8.6 0.0 2.7 3 0 0 3 3 3 2 CRISPR-associated protein (Cas_Cas2CT1978) Pyr_redox_2 PF07992.9 EWC48605.1 - 9e-28 97.5 0.0 1.1e-17 64.5 0.0 3.2 2 1 1 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 EWC48605.1 - 1.3e-12 47.8 0.1 4e-11 43.1 0.1 2.8 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 EWC48605.1 - 1.5e-05 25.2 0.1 0.0029 17.7 0.0 2.9 2 1 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase PIF1 PF05970.9 EWC48606.1 - 8.3e-63 212.5 0.3 1.5e-46 159.0 0.0 2.2 1 1 0 2 2 2 2 PIF1-like helicase AAA_30 PF13604.1 EWC48606.1 - 1.7e-15 57.1 0.0 3.5e-15 56.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 EWC48606.1 - 2.5e-06 27.6 0.0 6.2e-06 26.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain Herpes_Helicase PF02689.9 EWC48606.1 - 7.1e-06 24.0 0.6 0.00073 17.4 0.0 2.2 2 0 0 2 2 2 2 Helicase UvrD_C_2 PF13538.1 EWC48606.1 - 2.2e-05 24.5 0.1 0.00013 22.0 0.0 2.4 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA PF00004.24 EWC48606.1 - 0.0002 21.5 0.0 0.00047 20.3 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Viral_helicase1 PF01443.13 EWC48606.1 - 0.00034 20.2 0.2 1 8.8 0.1 2.7 2 1 0 2 2 2 2 Viral (Superfamily 1) RNA helicase AAA_19 PF13245.1 EWC48606.1 - 0.00075 19.2 0.1 0.0024 17.6 0.0 1.9 1 0 0 1 1 1 1 Part of AAA domain T2SE PF00437.15 EWC48606.1 - 0.0011 17.9 0.1 0.0018 17.2 0.1 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_16 PF13191.1 EWC48606.1 - 0.0016 18.4 0.0 0.0016 18.4 0.0 2.9 3 2 0 3 3 3 1 AAA ATPase domain NB-ARC PF00931.17 EWC48606.1 - 0.0024 16.7 0.1 0.0039 16.1 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain PhoH PF02562.11 EWC48606.1 - 0.0036 16.5 0.3 0.036 13.2 0.0 2.5 3 0 0 3 3 3 1 PhoH-like protein DUF2075 PF09848.4 EWC48606.1 - 0.006 15.6 0.0 0.014 14.4 0.0 1.6 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_5 PF07728.9 EWC48606.1 - 0.01 15.5 0.1 0.047 13.4 0.1 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_29 PF13555.1 EWC48606.1 - 0.012 15.1 0.0 0.033 13.7 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain TrwB_AAD_bind PF10412.4 EWC48606.1 - 0.018 13.7 0.1 0.036 12.6 0.1 1.5 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain NACHT PF05729.7 EWC48606.1 - 0.02 14.5 0.0 0.046 13.3 0.0 1.6 1 0 0 1 1 1 0 NACHT domain ABC_tran PF00005.22 EWC48606.1 - 0.024 14.9 0.0 0.088 13.1 0.0 2.0 1 0 0 1 1 1 0 ABC transporter AAA_14 PF13173.1 EWC48606.1 - 0.036 13.9 0.0 0.12 12.2 0.0 1.9 1 1 0 1 1 1 0 AAA domain Sigma54_activat PF00158.21 EWC48606.1 - 0.042 13.3 0.1 0.096 12.1 0.1 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain DUF258 PF03193.11 EWC48606.1 - 0.096 11.8 0.2 0.18 11.0 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 YjeF_N PF03853.10 EWC48607.1 - 2.5e-37 128.0 0.0 4.1e-37 127.3 0.0 1.3 1 0 0 1 1 1 1 YjeF-related protein N-terminus FDF PF09532.5 EWC48607.1 - 5.9e-05 23.5 5.6 5.9e-05 23.5 3.9 2.3 2 2 0 2 2 2 1 FDF domain SM-ATX PF14438.1 EWC48607.1 - 0.0096 15.8 0.3 0.019 14.8 0.2 1.5 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM PF01423.17 EWC48607.1 - 0.025 14.1 0.0 0.31 10.6 0.0 2.3 2 0 0 2 2 2 0 LSM domain Tmemb_cc2 PF10267.4 EWC48608.1 - 0.0041 15.7 0.4 0.0056 15.3 0.3 1.3 1 0 0 1 1 1 1 Predicted transmembrane and coiled-coil 2 protein NBP1 PF08537.5 EWC48608.1 - 0.067 12.3 0.1 0.099 11.8 0.1 1.2 1 0 0 1 1 1 0 Fungal Nap binding protein NBP1 Prefoldin_3 PF13758.1 EWC48608.1 - 0.44 10.3 2.5 0.33 10.7 0.3 2.0 2 1 0 2 2 2 0 Prefoldin subunit IF-2B PF01008.12 EWC48609.1 - 3.2e-77 259.3 1.8 3.6e-77 259.1 1.3 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family Med2 PF11214.3 EWC48610.1 - 0.0015 18.5 0.1 0.0027 17.6 0.0 1.4 1 0 0 1 1 1 1 Mediator complex subunit 2 DUF3439 PF11921.3 EWC48611.1 - 0.79 9.4 4.6 5.5 6.7 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF3439) Sporozoite_P67 PF05642.6 EWC48611.1 - 1.3 6.8 11.8 1.9 6.2 8.1 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen AAA PF00004.24 EWC48612.1 - 1.7e-95 316.2 0.0 1.5e-47 161.1 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) CDC48_N PF02359.13 EWC48612.1 - 7e-20 70.7 1.3 1.8e-19 69.4 0.5 2.0 2 0 0 2 2 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_2 PF07724.9 EWC48612.1 - 5.1e-15 55.7 0.1 1.8e-07 31.2 0.0 3.5 3 1 0 3 3 3 2 AAA domain (Cdc48 subfamily) RuvB_N PF05496.7 EWC48612.1 - 1.6e-13 50.2 0.0 9.3e-06 24.8 0.0 2.8 2 0 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_33 PF13671.1 EWC48612.1 - 1e-12 48.0 0.0 1.1e-05 25.3 0.0 2.9 3 0 0 3 3 2 2 AAA domain AAA_22 PF13401.1 EWC48612.1 - 1.3e-11 44.7 0.3 0.0017 18.5 0.0 4.1 2 2 0 2 2 2 2 AAA domain AAA_5 PF07728.9 EWC48612.1 - 1.5e-11 44.2 0.5 7.7e-06 25.6 0.0 3.9 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_17 PF13207.1 EWC48612.1 - 7.5e-11 42.9 0.0 0.00048 20.9 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.1 EWC48612.1 - 1.4e-10 41.4 0.0 0.0028 17.6 0.0 3.6 2 2 1 3 3 3 2 AAA ATPase domain TIP49 PF06068.8 EWC48612.1 - 2.5e-09 36.3 0.1 0.00092 18.0 0.0 2.6 2 0 0 2 2 2 2 TIP49 C-terminus CDC48_2 PF02933.12 EWC48612.1 - 3.7e-09 36.0 0.3 1.1e-08 34.6 0.0 1.9 2 0 0 2 2 1 1 Cell division protein 48 (CDC48), domain 2 AAA_25 PF13481.1 EWC48612.1 - 1.4e-08 34.4 3.3 0.013 14.9 0.0 4.4 2 2 2 4 4 4 2 AAA domain Mg_chelatase PF01078.16 EWC48612.1 - 5.5e-08 32.2 0.4 0.0046 16.1 0.0 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.12 EWC48612.1 - 6.8e-08 32.1 0.0 0.005 16.2 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_14 PF13173.1 EWC48612.1 - 8.1e-08 32.2 0.0 0.0034 17.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.1 EWC48612.1 - 1.3e-07 31.2 1.1 0.0087 15.7 0.0 3.0 2 0 0 2 2 2 2 Part of AAA domain Zeta_toxin PF06414.7 EWC48612.1 - 1.6e-07 30.6 0.0 0.0089 15.1 0.0 2.6 2 0 0 2 2 2 2 Zeta toxin RNA_helicase PF00910.17 EWC48612.1 - 5.8e-07 29.6 0.0 0.024 14.7 0.0 2.8 2 0 0 2 2 2 2 RNA helicase KaiC PF06745.8 EWC48612.1 - 1.5e-06 27.4 0.7 0.45 9.6 0.0 3.4 2 1 1 3 3 3 2 KaiC ResIII PF04851.10 EWC48612.1 - 3e-06 27.1 0.0 0.0031 17.3 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_24 PF13479.1 EWC48612.1 - 5e-06 26.2 0.2 0.095 12.2 0.0 3.0 3 0 0 3 3 2 2 AAA domain AAA_18 PF13238.1 EWC48612.1 - 6.1e-06 26.5 0.0 0.087 13.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_28 PF13521.1 EWC48612.1 - 6.7e-06 26.1 0.0 0.09 12.7 0.0 2.6 2 0 0 2 2 2 2 AAA domain DUF815 PF05673.8 EWC48612.1 - 9.1e-06 24.7 0.0 0.0098 14.8 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF815) Parvo_NS1 PF01057.12 EWC48612.1 - 1.2e-05 24.2 0.1 0.042 12.7 0.0 2.2 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 Sigma54_activat PF00158.21 EWC48612.1 - 2.4e-05 23.8 0.1 0.29 10.5 0.0 3.3 2 2 0 2 2 2 2 Sigma-54 interaction domain NACHT PF05729.7 EWC48612.1 - 3.3e-05 23.6 0.1 0.085 12.5 0.0 3.3 3 0 0 3 3 3 1 NACHT domain Arch_ATPase PF01637.13 EWC48612.1 - 4.1e-05 23.3 0.1 4.9 6.7 0.0 3.6 2 2 1 3 3 3 0 Archaeal ATPase Sigma54_activ_2 PF14532.1 EWC48612.1 - 5.1e-05 23.3 0.0 0.33 11.0 0.0 2.6 2 0 0 2 2 2 2 Sigma-54 interaction domain Bac_DnaA PF00308.13 EWC48612.1 - 7e-05 22.5 0.0 0.28 10.8 0.0 2.8 3 0 0 3 3 2 2 Bacterial dnaA protein Vps4_C PF09336.5 EWC48612.1 - 9.9e-05 22.1 0.1 0.00048 19.9 0.0 2.2 2 0 0 2 2 1 1 Vps4 C terminal oligomerisation domain PhoH PF02562.11 EWC48612.1 - 0.00016 21.0 0.4 0.47 9.6 0.0 2.5 2 0 0 2 2 2 2 PhoH-like protein ABC_tran PF00005.22 EWC48612.1 - 0.00018 21.8 0.0 0.38 11.0 0.0 3.5 2 1 0 2 2 2 1 ABC transporter AAA_30 PF13604.1 EWC48612.1 - 0.00026 20.6 0.0 0.31 10.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_3 PF07726.6 EWC48612.1 - 0.0003 20.3 0.0 0.96 9.0 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.17 EWC48612.1 - 0.00054 18.8 0.1 0.43 9.3 0.0 3.0 3 0 0 3 3 3 1 NB-ARC domain NTPase_1 PF03266.10 EWC48612.1 - 0.0012 18.5 0.4 0.64 9.7 0.0 3.9 4 0 0 4 4 3 1 NTPase DUF2075 PF09848.4 EWC48612.1 - 0.0013 17.8 0.0 1.2 8.0 0.0 2.3 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) AAA_11 PF13086.1 EWC48612.1 - 0.0014 18.2 0.0 1.4 8.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.13 EWC48612.1 - 0.0035 16.9 0.0 0.29 10.6 0.0 2.5 3 0 0 3 3 2 1 Viral (Superfamily 1) RNA helicase KAP_NTPase PF07693.9 EWC48612.1 - 0.0083 15.1 0.2 1 8.3 0.0 3.1 2 2 1 4 4 4 1 KAP family P-loop domain IPT PF01745.11 EWC48612.1 - 0.014 14.5 0.0 2 7.5 0.0 2.3 2 0 0 2 2 2 0 Isopentenyl transferase AAA_10 PF12846.2 EWC48612.1 - 0.014 14.8 0.5 1.6 8.0 0.0 3.5 3 1 1 4 4 4 0 AAA-like domain T2SE PF00437.15 EWC48612.1 - 0.02 13.8 0.0 1.9 7.2 0.0 2.6 2 0 0 2 2 2 0 Type II/IV secretion system protein AFG1_ATPase PF03969.11 EWC48612.1 - 0.06 12.1 0.0 9 4.9 0.0 2.5 2 0 0 2 2 2 0 AFG1-like ATPase UFD1 PF03152.9 EWC48612.1 - 0.06 12.4 0.0 3.8 6.6 0.0 2.3 1 1 1 2 2 2 0 Ubiquitin fusion degradation protein UFD1 Zot PF05707.7 EWC48612.1 - 0.068 12.6 0.3 11 5.3 0.1 3.5 3 1 0 3 3 2 0 Zonular occludens toxin (Zot) MobB PF03205.9 EWC48612.1 - 0.081 12.6 0.3 3.4 7.3 0.0 3.2 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B SKI PF01202.17 EWC48612.1 - 0.086 12.7 0.1 8.3 6.2 0.0 2.7 2 0 0 2 2 2 0 Shikimate kinase KTI12 PF08433.5 EWC48612.1 - 0.12 11.5 1.2 11 5.1 0.0 3.1 3 1 0 3 3 3 0 Chromatin associated protein KTI12 UPF0079 PF02367.12 EWC48612.1 - 0.12 11.9 0.1 12 5.5 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 PPV_E1_C PF00519.12 EWC48612.1 - 0.34 9.4 0.0 5.8 5.4 0.0 2.1 2 0 0 2 2 2 0 Papillomavirus helicase TIP120 PF08623.5 EWC48613.1 - 2.1e-60 203.1 7.1 8e-60 201.2 0.2 3.9 4 0 0 4 4 4 1 TATA-binding protein interacting (TIP20) HEAT_2 PF13646.1 EWC48613.1 - 1.5e-16 60.4 36.9 0.0019 18.4 0.1 10.7 8 3 4 12 12 12 9 HEAT repeats HEAT PF02985.17 EWC48613.1 - 2.2e-09 36.5 20.8 2.1 8.6 0.0 10.2 13 0 0 13 13 13 5 HEAT repeat Cnd3 PF12719.2 EWC48613.1 - 3.1e-07 29.6 3.6 0.5 9.2 0.0 4.8 4 0 0 4 4 4 4 Nuclear condensing complex subunits, C-term domain Vac14_Fab1_bd PF12755.2 EWC48613.1 - 1.7e-05 25.0 0.4 0.74 10.2 0.0 4.4 4 1 0 4 4 4 2 Vacuolar 14 Fab1-binding region DUF2435 PF10363.4 EWC48613.1 - 0.00016 21.5 8.6 0.24 11.2 0.1 5.3 4 0 0 4 4 4 2 Protein of unknown function (DUF2435) HEAT_EZ PF13513.1 EWC48613.1 - 0.00021 21.6 36.8 14 6.3 0.0 13.2 13 2 1 15 15 15 2 HEAT-like repeat Cnd1 PF12717.2 EWC48613.1 - 0.00033 20.5 5.5 0.2 11.4 0.0 5.8 5 3 0 5 5 5 1 non-SMC mitotic condensation complex subunit 1 DUF1546 PF07571.8 EWC48613.1 - 0.027 14.5 0.7 0.76 9.9 0.0 3.8 7 0 0 7 7 7 0 Protein of unknown function (DUF1546) CDC27 PF09507.5 EWC48614.1 - 0.3 10.2 79.5 0.39 9.9 55.1 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Borrelia_P83 PF05262.6 EWC48614.1 - 5.5 5.1 47.9 7.7 4.6 33.2 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein SAM_2 PF07647.12 EWC48615.1 - 1.8e-15 56.5 0.0 3e-15 55.7 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RA PF00788.18 EWC48615.1 - 3.1e-15 56.4 0.0 7.2e-15 55.2 0.0 1.5 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain SAM_1 PF00536.25 EWC48615.1 - 4.8e-15 55.4 0.1 8.2e-15 54.7 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) AAA PF00004.24 EWC48616.1 - 1.4e-06 28.5 1.0 8e-06 26.0 0.7 2.2 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 EWC48616.1 - 0.00012 22.8 0.0 0.00049 20.9 0.0 2.1 2 0 0 2 2 1 1 AAA domain AAA_16 PF13191.1 EWC48616.1 - 0.0022 17.9 0.0 0.023 14.6 0.0 2.5 2 1 0 2 2 2 1 AAA ATPase domain Rad17 PF03215.10 EWC48616.1 - 0.012 14.3 0.0 0.026 13.2 0.0 1.6 1 1 0 1 1 1 0 Rad17 cell cycle checkpoint protein AAA_18 PF13238.1 EWC48616.1 - 0.012 15.9 0.0 0.037 14.3 0.0 2.0 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.1 EWC48616.1 - 0.015 15.4 0.1 0.062 13.4 0.0 2.1 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.1 EWC48616.1 - 0.026 14.2 0.0 0.079 12.7 0.0 1.8 1 0 0 1 1 1 0 Part of AAA domain DUF2075 PF09848.4 EWC48616.1 - 0.032 13.2 0.0 0.061 12.2 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Zeta_toxin PF06414.7 EWC48616.1 - 0.033 13.2 0.1 0.063 12.3 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin DUF3605 PF12239.3 EWC48616.1 - 0.084 12.7 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3605) T2SE PF00437.15 EWC48616.1 - 0.11 11.4 0.0 0.2 10.5 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein HxlR PF01638.12 EWC48616.1 - 0.11 12.1 0.0 0.26 10.9 0.0 1.6 1 0 0 1 1 1 0 HxlR-like helix-turn-helix NTPase_1 PF03266.10 EWC48616.1 - 0.13 11.9 0.0 0.44 10.2 0.0 1.9 2 0 0 2 2 2 0 NTPase FNIP_N PF14636.1 EWC48618.1 - 1.7e-16 60.8 1.1 3.7e-15 56.5 0.0 3.5 2 1 0 2 2 2 1 Folliculin-interacting protein N-terminus FNIP_M PF14637.1 EWC48618.1 - 0.03 13.9 0.0 0.35 10.4 0.0 2.3 1 1 1 2 2 2 0 Folliculin-interacting protein middle domain DUF3608 PF12257.3 EWC48619.1 - 4e-80 268.7 0.2 8.6e-78 261.0 0.2 2.4 1 1 0 1 1 1 1 Protein of unknown function (DUF3608) DEP PF00610.16 EWC48619.1 - 5.7e-25 86.8 0.8 1.2e-24 85.8 0.5 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) RNA_pol PF00940.14 EWC48620.1 - 2.8e-163 543.1 0.0 4.3e-163 542.5 0.0 1.3 1 0 0 1 1 1 1 DNA-dependent RNA polymerase RPOL_N PF14700.1 EWC48620.1 - 7.7e-79 265.2 0.8 7.7e-79 265.2 0.5 1.9 2 0 0 2 2 2 1 DNA-directed RNA polymerase N-terminal NUC153 PF08159.7 EWC48621.1 - 1.8e-16 59.4 5.6 1.5e-10 40.4 0.1 3.8 3 0 0 3 3 3 3 NUC153 domain Nop53 PF07767.6 EWC48622.1 - 9.9e-93 311.1 21.8 1.3e-92 310.7 15.1 1.2 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) CorA PF01544.13 EWC48622.1 - 0.21 10.5 3.3 0.42 9.5 2.3 1.4 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Ycf1 PF05758.7 EWC48622.1 - 3.2 5.3 11.1 4.5 4.8 7.7 1.2 1 0 0 1 1 1 0 Ycf1 ScpA_ScpB PF02616.9 EWC48622.1 - 8.2 5.9 17.3 17 4.8 12.0 1.7 1 0 0 1 1 1 0 ScpA/B protein NMD3 PF04981.8 EWC48623.1 - 2.5e-72 242.8 4.9 3.9e-72 242.1 3.4 1.3 1 0 0 1 1 1 1 NMD3 family Rad4 PF03835.10 EWC48623.1 - 0.0063 15.9 1.0 0.0063 15.9 0.7 1.7 2 0 0 2 2 2 1 Rad4 transglutaminase-like domain RRM_1 PF00076.17 EWC48624.1 - 5.2e-08 32.4 0.1 6.8e-06 25.6 0.0 2.7 2 1 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EWC48624.1 - 5.5e-08 32.6 0.0 2.8e-07 30.4 0.0 2.2 1 1 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EWC48624.1 - 0.00016 21.4 0.0 0.0016 18.2 0.0 2.3 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) BBS2_C PF14782.1 EWC48624.1 - 0.068 11.7 0.9 0.096 11.2 0.6 1.1 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, C-terminal Nop14 PF04147.7 EWC48624.1 - 0.38 8.6 24.4 0.71 7.7 16.9 1.4 1 0 0 1 1 1 0 Nop14-like family CLTH PF10607.4 EWC48625.1 - 1.8e-33 115.3 0.0 3.2e-33 114.4 0.0 1.4 2 0 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.6 EWC48625.1 - 1.1e-06 28.1 0.0 2.4e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 LisH PfkB PF00294.19 EWC48626.1 - 5.7e-14 51.9 0.0 8.7e-14 51.3 0.0 1.1 1 0 0 1 1 1 1 pfkB family carbohydrate kinase PRK PF00485.13 EWC48627.1 - 9.3e-61 204.7 0.0 1.6e-60 203.9 0.0 1.4 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family UPRTase PF14681.1 EWC48627.1 - 1.8e-45 154.7 0.0 3e-45 153.9 0.0 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase AAA_17 PF13207.1 EWC48627.1 - 4.7e-12 46.7 0.0 9.6e-12 45.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 EWC48627.1 - 5.1e-08 33.2 0.0 1.2e-07 32.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 EWC48627.1 - 3.5e-05 23.7 0.0 0.00017 21.4 0.0 2.1 2 0 0 2 2 2 1 AAA domain CPT PF07931.7 EWC48627.1 - 4.4e-05 23.1 0.0 0.00012 21.7 0.0 1.8 2 0 0 2 2 2 1 Chloramphenicol phosphotransferase-like protein Pribosyltran PF00156.22 EWC48627.1 - 0.00065 19.4 0.0 0.0071 16.0 0.0 2.3 2 0 0 2 2 2 1 Phosphoribosyl transferase domain Zeta_toxin PF06414.7 EWC48627.1 - 0.0049 15.9 0.0 0.012 14.6 0.0 1.7 1 0 0 1 1 1 1 Zeta toxin AAA_16 PF13191.1 EWC48627.1 - 0.015 15.2 0.0 0.059 13.3 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain MobB PF03205.9 EWC48627.1 - 0.023 14.3 0.0 0.061 13.0 0.0 1.7 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_22 PF13401.1 EWC48627.1 - 0.037 14.1 0.0 0.11 12.6 0.0 1.7 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.12 EWC48627.1 - 0.092 12.5 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function DUF87 APS_kinase PF01583.15 EWC48627.1 - 0.099 12.3 0.0 0.36 10.4 0.0 1.9 2 0 0 2 2 2 0 Adenylylsulphate kinase ABC_tran PF00005.22 EWC48627.1 - 0.12 12.6 0.2 0.59 10.4 0.0 2.0 2 0 0 2 2 2 0 ABC transporter Thymidylate_kin PF02223.12 EWC48627.1 - 0.12 11.6 0.0 9.4 5.5 0.0 3.3 4 0 0 4 4 4 0 Thymidylate kinase ETC_C1_NDUFA4 PF04800.7 EWC48628.1 - 1.2e-39 134.2 1.7 1.7e-39 133.7 1.2 1.2 1 0 0 1 1 1 1 ETC complex I subunit conserved region F1F0-ATPsyn_F PF10791.4 EWC48629.1 - 7.7e-40 135.0 0.1 8.7e-40 134.8 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial F1-F0 ATP synthase subunit F of fungi WRW PF10206.4 EWC48629.1 - 8.1e-05 22.6 0.0 9.3e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial F1F0-ATP synthase, subunit f Nop25 PF09805.4 EWC48630.1 - 4.6 7.3 18.0 0.16 12.0 7.0 2.5 2 0 0 2 2 2 0 Nucleolar protein 12 (25kDa) CPSase_L_D2 PF02786.12 EWC48631.1 - 2e-114 380.1 0.8 9e-84 279.9 0.0 2.3 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_sm_chain PF00988.17 EWC48631.1 - 2.6e-45 153.1 0.0 5.9e-45 151.9 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.23 EWC48631.1 - 1.2e-44 152.1 0.0 3.1e-43 147.4 0.0 3.0 3 0 0 3 3 3 1 Glutamine amidotransferase class-I OTCace_N PF02729.16 EWC48631.1 - 5.3e-43 146.0 0.0 1.2e-42 144.8 0.0 1.7 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain CPSase_L_chain PF00289.17 EWC48631.1 - 1.7e-41 140.7 0.0 6.3e-21 74.5 0.0 2.9 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, N-terminal domain CPSase_L_D3 PF02787.14 EWC48631.1 - 2.6e-39 133.7 0.0 7.3e-39 132.3 0.0 1.8 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain ATP-grasp_4 PF13535.1 EWC48631.1 - 2.1e-37 128.6 0.2 4.3e-22 78.7 0.0 2.8 3 0 0 3 3 2 2 ATP-grasp domain OTCace PF00185.19 EWC48631.1 - 2.5e-34 118.4 0.0 7.8e-34 116.8 0.0 2.0 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain ATPgrasp_Ter PF15632.1 EWC48631.1 - 1.9e-23 82.7 0.1 7.4e-12 44.6 0.1 4.1 4 1 0 4 4 4 3 ATP-grasp in the biosynthetic pathway with Ter operon MGS PF02142.17 EWC48631.1 - 1.5e-17 63.3 0.0 5.9e-17 61.3 0.0 2.2 1 0 0 1 1 1 1 MGS-like domain Dala_Dala_lig_C PF07478.8 EWC48631.1 - 8.2e-17 61.2 1.0 5.2e-09 35.7 0.1 2.7 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATP-grasp PF02222.17 EWC48631.1 - 1.5e-15 56.9 0.2 1.4e-07 30.9 0.0 2.5 2 0 0 2 2 2 2 ATP-grasp domain RimK PF08443.6 EWC48631.1 - 7.1e-07 28.8 0.1 8.7e-06 25.3 0.1 2.3 2 0 0 2 2 2 1 RimK-like ATP-grasp domain Peptidase_C26 PF07722.8 EWC48631.1 - 1.8e-06 27.5 0.5 8.7e-05 22.0 0.0 3.1 3 1 0 3 3 3 1 Peptidase C26 ATP-grasp_3 PF02655.9 EWC48631.1 - 1.1e-05 25.2 0.8 0.042 13.7 0.1 2.7 2 0 0 2 2 2 2 ATP-grasp domain GARS_A PF01071.14 EWC48631.1 - 0.00066 19.2 0.4 0.34 10.4 0.1 3.0 2 1 0 2 2 2 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain DJ-1_PfpI PF01965.19 EWC48631.1 - 0.094 12.1 0.0 0.24 10.8 0.0 1.6 1 0 0 1 1 1 0 DJ-1/PfpI family Pex2_Pex12 PF04757.9 EWC48632.1 - 3.5e-56 190.1 7.0 4.3e-56 189.8 4.8 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_2 PF13923.1 EWC48632.1 - 2.4e-07 30.6 1.5 3.7e-07 30.0 1.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EWC48632.1 - 3.5e-05 23.3 0.7 5.5e-05 22.7 0.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 EWC48632.1 - 5e-05 23.0 2.3 8.4e-05 22.3 1.6 1.3 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.1 EWC48632.1 - 0.00043 19.8 0.2 0.00063 19.3 0.2 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EWC48632.1 - 0.0011 18.7 1.2 0.0017 18.1 0.8 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 EWC48632.1 - 0.014 15.4 2.0 0.056 13.5 1.4 1.9 1 1 0 1 1 1 0 RING-H2 zinc finger MT-A70 PF05063.9 EWC48633.1 - 5.8e-18 65.0 0.0 1e-17 64.2 0.0 1.4 1 0 0 1 1 1 1 MT-A70 DUF202 PF02656.10 EWC48634.1 - 2.2e-19 69.4 0.7 2.2e-19 69.4 0.5 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF202) Tic20 PF09685.5 EWC48634.1 - 0.018 14.9 0.2 0.033 14.1 0.1 1.6 1 1 0 1 1 1 0 Tic20-like protein Sulfate_transp PF00916.15 EWC48634.1 - 0.24 10.3 2.8 0.44 9.5 1.0 1.8 1 1 1 2 2 2 0 Sulfate transporter family zf-LITAF-like PF10601.4 EWC48634.1 - 1.3 8.8 5.8 3.2 7.6 1.1 2.5 3 0 0 3 3 3 0 LITAF-like zinc ribbon domain MatE PF01554.13 EWC48635.1 - 3.8e-62 208.6 24.2 6.1e-33 113.7 5.5 2.4 2 0 0 2 2 2 2 MatE PC_rep PF01851.17 EWC48636.1 - 4.8e-20 70.5 18.6 5.2e-05 23.2 0.1 8.6 9 0 0 9 9 9 5 Proteasome/cyclosome repeat HEAT_2 PF13646.1 EWC48636.1 - 4.9e-08 33.1 0.6 0.0014 18.8 0.0 4.4 4 1 0 4 4 4 2 HEAT repeats HEAT_EZ PF13513.1 EWC48636.1 - 0.0031 17.9 0.1 0.026 15.0 0.0 2.8 3 0 0 3 3 3 1 HEAT-like repeat HEAT PF02985.17 EWC48636.1 - 0.0064 16.4 0.0 22 5.4 0.1 4.0 3 0 0 3 3 3 2 HEAT repeat Daxx PF03344.10 EWC48637.1 - 0.014 13.8 10.6 0.022 13.3 7.3 1.2 1 0 0 1 1 1 0 Daxx Family Nop14 PF04147.7 EWC48637.1 - 0.016 13.1 18.5 0.025 12.5 12.8 1.2 1 0 0 1 1 1 0 Nop14-like family RRN3 PF05327.6 EWC48637.1 - 0.91 7.5 5.9 1.7 6.6 4.1 1.5 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 TFIIA PF03153.8 EWC48637.1 - 1.1 9.0 22.5 2.3 8.0 15.6 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CobT PF06213.7 EWC48637.1 - 5.7 5.9 21.6 9.8 5.2 15.0 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Kei1 PF08552.6 EWC48639.1 - 1.9e-49 167.8 0.0 2.8e-49 167.3 0.0 1.2 1 0 0 1 1 1 1 Inositolphosphorylceramide synthase subunit Kei1 Peptidase_M56 PF05569.6 EWC48639.1 - 0.034 13.1 0.6 0.13 11.2 0.4 1.7 1 1 0 1 1 1 0 BlaR1 peptidase M56 Methyltransf_31 PF13847.1 EWC48640.1 - 1.5e-19 70.0 0.0 2.2e-19 69.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EWC48640.1 - 1.6e-19 70.1 0.0 3.1e-19 69.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EWC48640.1 - 1.9e-13 50.4 0.0 3.2e-13 49.7 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EWC48640.1 - 9.3e-12 45.5 0.0 1.7e-11 44.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EWC48640.1 - 2e-10 41.0 0.0 3.7e-10 40.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EWC48640.1 - 2.3e-10 40.7 0.0 5e-10 39.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EWC48640.1 - 5.7e-08 32.1 0.0 9e-08 31.5 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MetW PF07021.7 EWC48640.1 - 5.1e-07 29.2 0.0 7.5e-07 28.7 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_26 PF13659.1 EWC48640.1 - 1e-06 28.7 1.1 3.2e-06 27.1 0.2 2.2 2 1 0 2 2 2 1 Methyltransferase domain MTS PF05175.9 EWC48640.1 - 0.00095 18.5 0.0 0.0015 17.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain FmrO PF07091.6 EWC48640.1 - 0.074 12.0 0.0 0.09 11.7 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA methyltransferase (FmrO) CheR PF01739.13 EWC48640.1 - 0.12 11.6 0.0 7.6 5.7 0.0 2.2 2 0 0 2 2 2 0 CheR methyltransferase, SAM binding domain Ribonuclease_3 PF00636.21 EWC48641.1 - 1e-39 135.5 0.0 8.3e-20 71.3 0.0 2.9 2 0 0 2 2 2 2 Ribonuclease III domain Ribonucleas_3_3 PF14622.1 EWC48641.1 - 7.9e-26 90.5 0.0 3.6e-12 46.3 0.0 3.3 2 1 0 2 2 2 2 Ribonuclease-III-like Dicer_dimer PF03368.9 EWC48641.1 - 5.5e-19 67.7 0.0 1.1e-17 63.5 0.0 2.7 2 0 0 2 2 2 1 Dicer dimerisation domain Helicase_C PF00271.26 EWC48641.1 - 4.1e-17 61.8 0.1 1.5e-16 60.0 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EWC48641.1 - 7.1e-12 45.5 0.4 4.6e-11 42.8 0.0 2.6 2 1 1 3 3 3 1 Type III restriction enzyme, res subunit DEAD PF00270.24 EWC48641.1 - 1.4e-10 40.9 0.0 3.2e-10 39.7 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase dsrm PF00035.20 EWC48641.1 - 1.5e-07 31.9 0.1 0.0042 17.6 0.0 2.8 2 0 0 2 2 2 2 Double-stranded RNA binding motif DUF1067 PF06362.6 EWC48641.1 - 0.099 13.2 0.0 0.3 11.6 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1067) Myb_Cef PF11831.3 EWC48642.1 - 1.6e-58 197.6 0.6 1.6e-58 197.6 0.4 2.9 3 0 0 3 3 3 1 pre-mRNA splicing factor component Myb_DNA-binding PF00249.26 EWC48642.1 - 4.9e-21 74.5 4.8 1.2e-09 38.0 0.2 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 EWC48642.1 - 1.3e-20 73.2 5.6 1.9e-14 53.4 1.1 3.0 1 1 1 2 2 2 2 Myb-like DNA-binding domain ParA PF10609.4 EWC48643.1 - 1.8e-34 117.4 0.0 3e-34 116.7 0.0 1.3 1 0 0 1 1 1 1 ParA/MinD ATPase like CbiA PF01656.18 EWC48643.1 - 1.4e-13 50.7 0.0 2.1e-13 50.1 0.0 1.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.1 EWC48643.1 - 9.3e-06 25.6 0.0 2e-05 24.5 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_26 PF13500.1 EWC48643.1 - 0.00016 21.3 0.1 0.012 15.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain ArsA_ATPase PF02374.10 EWC48643.1 - 0.00028 20.0 1.0 0.0056 15.7 0.2 2.5 2 1 1 3 3 3 1 Anion-transporting ATPase MipZ PF09140.6 EWC48643.1 - 0.0019 17.3 0.0 0.0033 16.5 0.0 1.4 1 1 0 1 1 1 1 ATPase MipZ DUF258 PF03193.11 EWC48643.1 - 0.022 13.9 0.1 0.038 13.1 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_25 PF13481.1 EWC48643.1 - 0.029 13.7 0.1 0.058 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain Fer4_NifH PF00142.13 EWC48643.1 - 0.071 12.2 0.1 0.57 9.3 0.1 2.3 2 2 1 3 3 3 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family Zn_Tnp_IS1595 PF12760.2 EWC48643.1 - 0.083 12.7 0.0 0.31 10.8 0.0 1.9 1 0 0 1 1 1 0 Transposase zinc-ribbon domain TF_Zn_Ribbon PF08271.7 EWC48643.1 - 0.087 12.1 0.1 0.2 11.0 0.1 1.6 1 0 0 1 1 1 0 TFIIB zinc-binding RNA_helicase PF00910.17 EWC48643.1 - 0.15 12.2 0.0 0.32 11.2 0.0 1.6 1 0 0 1 1 1 0 RNA helicase RNase_PH PF01138.16 EWC48644.1 - 9.4e-26 90.6 0.1 1.7e-25 89.8 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 Suf PF05843.9 EWC48651.1 - 1.3e-10 41.4 13.7 0.023 14.4 0.0 6.1 4 1 1 6 6 6 4 Suppressor of forked protein (Suf) TPR_14 PF13428.1 EWC48651.1 - 1.4e-10 40.7 3.7 9.1 7.2 0.0 10.0 9 1 2 11 11 10 1 Tetratricopeptide repeat TPR_12 PF13424.1 EWC48651.1 - 1.3e-07 31.4 3.5 12 5.8 0.0 7.6 7 1 0 7 7 7 0 Tetratricopeptide repeat Mad3_BUB1_I PF08311.7 EWC48651.1 - 0.00011 22.0 16.1 1.1 9.0 0.1 7.4 6 1 1 8 8 8 2 Mad3/BUB1 homology region 1 TPR_16 PF13432.1 EWC48651.1 - 0.00023 21.7 2.5 0.29 11.8 0.0 5.6 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_19 PF14559.1 EWC48651.1 - 0.00042 20.6 0.2 1.6 9.1 0.0 5.3 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_2 PF07719.12 EWC48651.1 - 0.00074 19.2 14.9 2 8.5 0.0 8.1 11 0 0 11 11 9 1 Tetratricopeptide repeat RPN7 PF10602.4 EWC48651.1 - 0.001 18.5 0.4 0.023 14.0 0.1 3.0 3 1 0 3 3 3 1 26S proteasome subunit RPN7 TPR_7 PF13176.1 EWC48651.1 - 0.001 18.6 8.7 6.2 6.8 0.0 7.1 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_11 PF13414.1 EWC48651.1 - 0.0024 17.4 8.8 6.1 6.5 0.0 7.0 8 1 1 9 9 9 1 TPR repeat NRDE-2 PF08424.5 EWC48651.1 - 0.0028 16.6 12.4 0.054 12.3 0.1 4.5 2 2 1 3 3 3 2 NRDE-2, necessary for RNA interference TPR_8 PF13181.1 EWC48651.1 - 0.037 13.8 3.4 38 4.3 0.0 5.6 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_17 PF13431.1 EWC48651.1 - 0.24 11.6 3.9 59 4.2 0.0 5.2 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_10 PF13374.1 EWC48651.1 - 4.4 7.3 10.5 11 6.1 0.0 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat ATP-synt_D PF01813.12 EWC48652.1 - 6.4e-66 221.6 1.8 9.6e-66 221.0 1.2 1.2 1 0 0 1 1 1 1 ATP synthase subunit D GAS PF13851.1 EWC48652.1 - 0.12 11.5 7.7 0.53 9.4 0.0 2.2 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding Ax_dynein_light PF10211.4 EWC48652.1 - 3.2 7.5 9.6 16 5.2 4.1 2.1 2 0 0 2 2 2 0 Axonemal dynein light chain Viral_P18 PF04521.8 EWC48652.1 - 4.2 6.8 7.2 9.9 5.6 0.1 2.3 2 0 0 2 2 2 0 ssRNA positive strand viral 18kD cysteine rich protein cIII PF08134.6 EWC48653.1 - 0.051 13.1 0.0 0.12 12.0 0.0 1.6 1 0 0 1 1 1 0 cIII protein family Pkinase PF00069.20 EWC48654.1 - 9e-63 211.8 0.0 1.4e-62 211.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC48654.1 - 1.4e-34 119.3 0.0 1.4e-29 103.0 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 EWC48654.1 - 0.00033 19.7 0.0 0.23 10.3 0.0 2.2 2 0 0 2 2 2 2 Kinase-like APH PF01636.18 EWC48654.1 - 0.0013 18.4 0.1 0.0025 17.5 0.1 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.17 EWC48654.1 - 0.26 10.5 0.0 0.55 9.5 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Dus PF01207.12 EWC48655.1 - 4.9e-48 163.5 0.0 4e-37 127.7 0.0 2.3 2 0 0 2 2 2 2 Dihydrouridine synthase (Dus) zf-CCCH PF00642.19 EWC48655.1 - 0.0038 16.8 2.2 0.39 10.4 0.1 3.0 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF2795 PF11387.3 EWC48657.1 - 2.1e-06 27.4 0.0 0.016 15.0 0.0 3.1 3 0 0 3 3 3 2 Protein of unknown function (DUF2795) DUF3682 PF12446.3 EWC48657.1 - 0.00077 19.7 2.3 0.00077 19.7 1.6 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF3682) DUF3812 PF12757.2 EWC48657.1 - 0.0079 16.1 0.2 0.016 15.1 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3812) Glyco_transf_28 PF03033.15 EWC48658.1 - 5.5e-18 65.0 0.0 1.3e-17 63.8 0.0 1.7 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain UDPGT PF00201.13 EWC48658.1 - 0.001 17.7 0.1 0.0016 17.0 0.1 1.2 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.11 EWC48658.1 - 0.063 12.9 6.3 0.1 12.2 0.0 2.9 2 1 0 2 2 2 0 Glycosyltransferase family 28 C-terminal domain Cnd3 PF12719.2 EWC48658.1 - 0.11 11.5 4.2 0.18 10.7 2.9 1.3 1 0 0 1 1 1 0 Nuclear condensing complex subunits, C-term domain DUF445 PF04286.7 EWC48658.1 - 0.31 10.5 8.1 0.5 9.8 5.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF445) TMEM154 PF15102.1 EWC48659.1 - 2.3e-05 24.1 0.1 5.1e-05 23.0 0.1 1.6 1 0 0 1 1 1 1 TMEM154 protein family Alpha_GJ PF03229.8 EWC48659.1 - 0.00018 21.8 2.3 0.00076 19.8 1.6 2.0 1 0 0 1 1 1 1 Alphavirus glycoprotein J Lamp PF01299.12 EWC48659.1 - 0.00031 20.0 0.9 0.00031 20.0 0.6 2.7 2 1 1 3 3 3 1 Lysosome-associated membrane glycoprotein (Lamp) Glycophorin_A PF01102.13 EWC48659.1 - 0.00054 19.7 0.2 0.00054 19.7 0.1 2.3 2 0 0 2 2 2 1 Glycophorin A Herpes_gE PF02480.11 EWC48659.1 - 0.0022 16.3 0.0 0.0039 15.5 0.0 1.3 1 0 0 1 1 1 1 Alphaherpesvirus glycoprotein E Mid2 PF04478.7 EWC48659.1 - 0.0071 15.7 0.1 0.016 14.5 0.0 1.6 1 0 0 1 1 1 1 Mid2 like cell wall stress sensor EphA2_TM PF14575.1 EWC48659.1 - 0.027 14.8 0.0 0.069 13.5 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain CD34_antigen PF06365.7 EWC48659.1 - 0.083 12.5 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 CD34/Podocalyxin family PEMT PF04191.8 EWC48660.1 - 4.2e-55 184.3 14.0 1.1e-33 115.4 0.4 2.8 3 0 0 3 3 3 2 Phospholipid methyltransferase Fig1 PF12351.3 EWC48661.1 - 2.8e-19 69.7 7.1 2.8e-19 69.7 4.9 1.4 2 0 0 2 2 2 1 Ca2+ regulator and membrane fusion protein Fig1 SUR7 PF06687.7 EWC48661.1 - 1.2 8.6 12.9 13 5.2 9.0 2.0 1 1 0 1 1 1 0 SUR7/PalI family MS_channel PF00924.13 EWC48661.1 - 5.1 6.3 6.6 0.39 10.0 0.7 2.0 2 0 0 2 2 2 0 Mechanosensitive ion channel p450 PF00067.17 EWC48662.1 - 6.6e-36 123.8 0.1 8.4e-36 123.4 0.1 1.1 1 0 0 1 1 1 1 Cytochrome P450 ADH_N PF08240.7 EWC48663.1 - 5.3e-29 100.1 0.3 1.1e-28 99.2 0.2 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 EWC48663.1 - 5.2e-14 51.9 0.0 9.4e-14 51.0 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Pyr_redox_3 PF13738.1 EWC48663.1 - 0.12 12.4 0.1 0.26 11.3 0.0 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DUF221 PF02714.10 EWC48664.1 - 2.7e-114 381.4 20.8 2.7e-114 381.4 14.4 2.5 3 0 0 3 3 3 1 Domain of unknown function DUF221 RSN1_TM PF13967.1 EWC48664.1 - 1.1e-45 155.0 2.6 1.1e-45 155.0 1.8 3.0 4 1 0 4 4 4 1 Late exocytosis, associated with Golgi transport DUF3779 PF12621.3 EWC48664.1 - 1.3e-22 79.5 0.3 2.9e-22 78.3 0.2 1.6 1 0 0 1 1 1 1 Phosphate metabolism protein DUF4463 PF14703.1 EWC48664.1 - 2.2e-19 69.7 1.5 3.7e-19 69.0 1.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4463) RRM_6 PF14259.1 EWC48664.1 - 0.043 13.7 0.0 0.1 12.5 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) DUF912 PF06024.7 EWC48664.1 - 1.5 8.8 0.0 1.5 8.8 0.0 3.2 4 0 0 4 4 4 0 Nucleopolyhedrovirus protein of unknown function (DUF912) zf-C2H2_4 PF13894.1 EWC48665.1 - 9.1e-07 28.7 11.4 0.034 14.4 1.3 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger zf-H2C2_2 PF13465.1 EWC48665.1 - 0.0019 18.4 15.4 0.0022 18.2 0.9 3.1 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_jaz PF12171.3 EWC48665.1 - 0.079 13.1 7.9 0.36 11.0 1.2 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.21 EWC48665.1 - 0.36 11.2 26.3 0.11 12.8 0.5 3.8 4 0 0 4 4 4 0 Zinc finger, C2H2 type Amidase PF01425.16 EWC48666.1 - 5.6e-74 249.5 0.2 8e-74 249.0 0.1 1.2 1 0 0 1 1 1 1 Amidase Intg_mem_TP0381 PF09529.5 EWC48668.1 - 0.042 13.0 8.2 0.54 9.4 0.0 3.3 3 1 1 4 4 4 0 Integral membrane protein (intg_mem_TP0381) Pkinase PF00069.20 EWC48669.1 - 1.8e-07 30.5 0.0 3e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 EWC48669.1 - 0.042 12.9 0.0 0.075 12.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 EWC48669.1 - 0.099 12.3 0.1 0.3 10.7 0.0 1.9 2 0 0 2 2 2 0 Phosphotransferase enzyme family F-box-like PF12937.2 EWC48671.1 - 4.2e-08 32.8 0.0 1.6e-07 30.9 0.0 2.0 2 0 0 2 2 2 1 F-box-like F-box-like_2 PF13013.1 EWC48671.1 - 0.11 12.2 0.1 0.33 10.7 0.0 1.8 2 0 0 2 2 2 0 F-box-like domain AAA_17 PF13207.1 EWC48672.1 - 1.3e-08 35.6 0.0 3.5e-08 34.3 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.1 EWC48672.1 - 2.2e-08 34.1 0.0 0.00092 19.1 0.0 2.2 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.1 EWC48672.1 - 2.2e-07 31.2 0.1 1.4e-06 28.6 0.0 2.1 1 1 0 1 1 1 1 AAA domain SKI PF01202.17 EWC48672.1 - 5.2e-07 29.6 0.0 0.0024 17.7 0.0 2.2 2 0 0 2 2 2 2 Shikimate kinase AAA_19 PF13245.1 EWC48672.1 - 0.00037 20.1 0.0 0.0008 19.1 0.0 1.5 1 0 0 1 1 1 1 Part of AAA domain IPT PF01745.11 EWC48672.1 - 0.043 12.9 0.0 0.081 12.0 0.0 1.4 1 0 0 1 1 1 0 Isopentenyl transferase AAA PF00004.24 EWC48672.1 - 0.048 13.8 0.0 0.1 12.7 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 EWC48672.1 - 0.066 13.1 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain Zeta_toxin PF06414.7 EWC48672.1 - 0.077 12.0 0.0 0.13 11.3 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin ADK PF00406.17 EWC48672.1 - 0.13 12.1 1.0 2.5 7.9 0.0 2.3 2 1 0 2 2 2 0 Adenylate kinase AAA_22 PF13401.1 EWC48672.1 - 0.16 12.1 0.1 0.54 10.4 0.1 1.9 1 1 0 1 1 1 0 AAA domain CoaE PF01121.15 EWC48672.1 - 0.16 11.3 0.9 0.4 10.0 0.0 2.0 3 0 0 3 3 3 0 Dephospho-CoA kinase Ank_2 PF12796.2 EWC48673.1 - 7.1e-91 298.6 23.2 4.3e-14 52.6 0.4 11.9 3 3 11 14 14 14 14 Ankyrin repeats (3 copies) Ank_4 PF13637.1 EWC48673.1 - 1.7e-55 184.4 14.6 1.7e-06 28.3 0.0 16.0 8 5 10 18 18 18 16 Ankyrin repeats (many copies) Ank PF00023.25 EWC48673.1 - 2.2e-55 181.8 22.5 1.6e-05 24.4 0.0 17.2 16 1 0 16 16 16 13 Ankyrin repeat Ank_3 PF13606.1 EWC48673.1 - 7.3e-51 165.0 16.6 0.00025 20.9 0.0 18.4 18 0 0 18 18 18 12 Ankyrin repeat Ank_5 PF13857.1 EWC48673.1 - 2.6e-41 138.7 22.9 3.4e-05 23.9 0.1 15.1 9 6 5 14 14 14 12 Ankyrin repeats (many copies) Pyridox_oxase_2 PF12766.2 EWC48674.1 - 8.1e-22 77.4 0.0 1.3e-21 76.7 0.0 1.4 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Jacalin PF01419.12 EWC48676.1 - 6.5e-07 29.2 0.9 0.0025 17.7 0.0 3.4 4 0 0 4 4 4 2 Jacalin-like lectin domain F-box PF00646.28 EWC48676.1 - 0.017 14.7 0.4 0.051 13.2 0.3 1.8 1 0 0 1 1 1 0 F-box domain adh_short PF00106.20 EWC48677.1 - 6.4e-22 78.2 3.3 8.9e-22 77.7 2.3 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EWC48677.1 - 1.9e-09 37.4 2.7 6.6e-09 35.6 2.0 1.8 1 1 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 EWC48677.1 - 1.4e-06 28.2 0.1 1.8e-06 27.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase PDZ_1 PF12812.2 EWC48678.1 - 1.3e-28 98.6 0.0 1.3e-21 76.2 0.0 2.8 2 0 0 2 2 2 2 PDZ-like domain Trypsin_2 PF13365.1 EWC48678.1 - 6.3e-10 39.0 0.0 1.6e-09 37.7 0.0 1.8 1 0 0 1 1 1 1 Trypsin-like peptidase domain PDZ_2 PF13180.1 EWC48678.1 - 1.3e-09 37.7 0.1 0.024 14.5 0.0 4.6 4 0 0 4 4 4 3 PDZ domain PDZ PF00595.19 EWC48678.1 - 0.00082 19.5 0.0 3.4 7.9 0.0 4.2 4 1 1 5 5 5 1 PDZ domain (Also known as DHR or GLGF) Peptidase_S46 PF10459.4 EWC48678.1 - 0.0096 14.3 0.1 0.016 13.6 0.1 1.2 1 0 0 1 1 1 1 Peptidase S46 Peptidase_S7 PF00949.16 EWC48678.1 - 0.047 13.0 1.7 0.1 12.0 1.2 1.5 1 0 0 1 1 1 0 Peptidase S7, Flavivirus NS3 serine protease DUF3431 PF11913.3 EWC48679.1 - 6.1e-67 225.3 0.0 8.4e-67 224.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3431) Response_reg PF00072.19 EWC48680.1 - 7e-21 74.3 0.1 1.4e-20 73.3 0.1 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HATPase_c PF02518.21 EWC48680.1 - 9e-20 70.4 0.0 1.7e-19 69.5 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.20 EWC48680.1 - 1.7e-07 31.1 0.1 5.3e-07 29.5 0.1 1.9 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_9 PF13426.1 EWC48680.1 - 3.1e-07 30.7 0.0 7e-06 26.3 0.0 2.9 3 0 0 3 3 3 1 PAS domain PAS_4 PF08448.5 EWC48680.1 - 2.2e-05 24.4 0.0 0.0016 18.4 0.0 3.6 4 0 0 4 4 4 1 PAS fold PAS PF00989.19 EWC48680.1 - 0.00027 20.7 0.0 0.0012 18.6 0.0 2.2 2 0 0 2 2 2 1 PAS fold PAS_3 PF08447.6 EWC48680.1 - 0.00087 19.3 0.1 0.0041 17.1 0.0 2.1 2 0 0 2 2 2 1 PAS fold Senescence PF06911.7 EWC48681.1 - 4.2e-32 111.2 12.7 8e-20 71.2 1.9 2.5 1 1 1 2 2 2 2 Senescence-associated protein Acyl-CoA_dh_1 PF00441.19 EWC48682.1 - 5.3e-41 140.1 6.2 8e-41 139.6 4.3 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.14 EWC48682.1 - 4.5e-20 70.8 0.0 8.3e-20 70.0 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.11 EWC48682.1 - 1.7e-18 67.2 0.1 4.6e-18 65.8 0.1 1.8 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.6 EWC48682.1 - 1.8e-15 57.3 2.4 1.8e-15 57.3 1.7 1.7 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.3 EWC48682.1 - 0.0086 15.4 0.0 0.033 13.5 0.0 1.9 1 1 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase N terminal DUF4448 PF14610.1 EWC48683.1 - 2.5e-30 105.3 0.0 4.6e-30 104.5 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) SKG6 PF08693.5 EWC48683.1 - 0.034 13.4 0.4 0.097 12.0 0.3 1.7 1 0 0 1 1 1 0 Transmembrane alpha-helix domain MtrF PF09472.5 EWC48683.1 - 2.4 7.4 4.3 4.7 6.5 3.0 1.4 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) ABC_membrane_2 PF06472.10 EWC48684.1 - 3.1e-92 308.6 0.1 5.2e-92 307.9 0.1 1.4 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.22 EWC48684.1 - 1e-17 64.7 0.0 2.3e-17 63.5 0.0 1.6 2 0 0 2 2 1 1 ABC transporter AAA_21 PF13304.1 EWC48684.1 - 0.00047 20.2 0.0 0.001 19.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.1 EWC48684.1 - 0.002 17.6 0.0 0.023 14.2 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_17 PF13207.1 EWC48684.1 - 0.0073 17.1 0.0 0.051 14.4 0.0 2.3 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.16 EWC48684.1 - 0.011 14.9 0.0 0.021 14.0 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_16 PF13191.1 EWC48684.1 - 0.011 15.7 0.1 0.032 14.2 0.1 1.7 1 0 0 1 1 1 0 AAA ATPase domain ALIX_LYPXL_bnd PF13949.1 EWC48684.1 - 0.012 14.6 0.3 0.019 13.9 0.2 1.2 1 0 0 1 1 1 0 ALIX V-shaped domain binding to HIV FtsK_SpoIIIE PF01580.13 EWC48684.1 - 0.015 14.8 0.0 0.03 13.8 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family DUF4391 PF14335.1 EWC48684.1 - 0.016 14.6 0.7 0.024 14.0 0.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4391) AAA_23 PF13476.1 EWC48684.1 - 0.022 15.1 0.5 1.8 8.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain Sigma54_activ_2 PF14532.1 EWC48684.1 - 0.024 14.6 0.0 0.067 13.2 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain End3 PF12761.2 EWC48684.1 - 0.03 13.9 0.2 0.058 13.0 0.1 1.4 1 0 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 SMC_N PF02463.14 EWC48684.1 - 0.039 13.1 0.8 0.1 11.7 0.0 2.0 3 0 0 3 3 3 0 RecF/RecN/SMC N terminal domain AAA_22 PF13401.1 EWC48684.1 - 0.058 13.5 0.0 0.14 12.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.1 EWC48684.1 - 0.12 12.1 0.3 0.81 9.4 0.0 2.5 2 0 0 2 2 2 0 Part of AAA domain ATP-synt_G PF04718.10 EWC48685.1 - 3.9e-21 75.6 0.2 6.4e-20 71.7 0.0 2.2 2 0 0 2 2 2 1 Mitochondrial ATP synthase g subunit Helicase_C PF00271.26 EWC48686.1 - 4.7e-25 87.2 0.1 1.1e-24 86.1 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 EWC48686.1 - 7.7e-25 87.3 0.1 7.1e-16 58.1 0.0 2.4 2 0 0 2 2 2 2 DEAD/DEAH box helicase ResIII PF04851.10 EWC48686.1 - 2.6e-06 27.3 0.0 7.8e-06 25.8 0.0 1.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Glyco_trans_1_4 PF13692.1 EWC48686.1 - 0.031 14.4 0.0 0.066 13.3 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferases group 1 DUF1253 PF06862.7 EWC48686.1 - 0.19 10.1 2.6 0.77 8.0 0.0 2.7 4 0 0 4 4 4 0 Protein of unknown function (DUF1253) eIF-3c_N PF05470.7 EWC48686.1 - 1.3 6.9 5.2 0.71 7.8 0.0 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Fungal_trans PF04082.13 EWC48687.1 - 3.1e-39 134.4 0.0 5e-39 133.7 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EWC48687.1 - 5.1e-09 35.8 8.0 9.4e-09 35.0 5.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.11 EWC48688.1 - 6.7e-29 100.6 23.3 6.7e-29 100.6 16.1 2.1 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_1_like PF12832.2 EWC48688.1 - 1.2 9.0 6.3 0.12 12.1 0.4 2.5 3 0 0 3 3 3 0 MFS_1 like family TFCD_C PF12612.3 EWC48689.1 - 5.3e-29 101.0 0.0 1.6e-27 96.1 0.0 2.7 2 0 0 2 2 2 1 Tubulin folding cofactor D C terminal HEAT_2 PF13646.1 EWC48689.1 - 8.9e-06 25.8 2.1 0.0078 16.4 0.2 5.1 6 0 0 6 6 6 1 HEAT repeats Vac14_Fab1_bd PF12755.2 EWC48689.1 - 1.5e-05 25.2 0.0 0.094 13.1 0.0 4.2 3 0 0 3 3 3 2 Vacuolar 14 Fab1-binding region HEAT PF02985.17 EWC48689.1 - 0.00075 19.3 11.7 0.042 13.9 0.2 7.0 7 0 0 7 7 7 1 HEAT repeat HEAT_EZ PF13513.1 EWC48689.1 - 0.032 14.7 0.1 0.032 14.7 0.0 5.7 7 1 1 8 8 8 0 HEAT-like repeat Cnd1 PF12717.2 EWC48689.1 - 0.13 12.0 0.1 8.1 6.2 0.0 3.6 4 0 0 4 4 4 0 non-SMC mitotic condensation complex subunit 1 Metallophos PF00149.23 EWC48690.1 - 1.8e-33 115.6 0.2 8.5e-30 103.6 0.1 2.1 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase Hemerythrin PF01814.18 EWC48692.1 - 1.2e-10 41.6 6.0 2.1e-10 40.8 4.2 1.3 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain ThiF PF00899.16 EWC48694.1 - 6.4e-53 178.2 0.0 1.7e-30 105.6 0.0 2.3 2 0 0 2 2 2 2 ThiF family UBA_e1_C PF09358.5 EWC48694.1 - 1.3e-38 131.9 0.0 4e-38 130.4 0.0 1.8 2 0 0 2 2 2 1 Ubiquitin-activating enzyme e1 C-terminal domain UBACT PF02134.16 EWC48694.1 - 4.2e-37 125.5 0.1 8.9e-26 89.2 0.1 2.6 2 0 0 2 2 2 2 Repeat in ubiquitin-activating (UBA) protein UBA_e1_thiolCys PF10585.4 EWC48694.1 - 4.5e-22 77.1 0.5 5.3e-18 64.1 0.1 2.4 2 0 0 2 2 2 2 Ubiquitin-activating enzyme active site GST_N_2 PF13409.1 EWC48695.1 - 8e-22 77.0 0.0 1.5e-21 76.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 EWC48695.1 - 5.3e-14 51.8 0.0 1e-13 50.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 EWC48695.1 - 7.8e-09 35.4 0.0 1.6e-08 34.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 EWC48695.1 - 1.5e-05 25.3 0.0 3.1e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.1 EWC48695.1 - 0.00053 20.1 0.0 0.013 15.6 0.0 2.3 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Neugrin PF06413.6 EWC48696.1 - 0.011 15.6 2.3 0.017 14.9 0.0 2.2 2 1 0 2 2 2 0 Neugrin MRG PF05712.8 EWC48697.1 - 9.8e-50 168.1 1.4 1.4e-49 167.6 1.0 1.3 1 1 0 1 1 1 1 MRG Tudor-knot PF11717.3 EWC48697.1 - 2.5e-10 39.9 0.2 4.8e-10 38.9 0.1 1.5 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain AMP-binding PF00501.23 EWC48698.1 - 6.5e-86 288.3 0.0 7.9e-86 288.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 EWC48698.1 - 1.2e-22 80.5 0.3 1.8e-20 73.6 0.2 2.6 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Reprolysin_5 PF13688.1 EWC48699.1 - 8.1e-53 179.2 2.5 8.1e-53 179.2 1.7 2.3 2 1 0 2 2 2 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.1 EWC48699.1 - 7.5e-47 159.5 0.1 1.3e-46 158.7 0.1 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.1 EWC48699.1 - 3.8e-43 147.5 0.5 7.2e-43 146.6 0.3 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.1 EWC48699.1 - 5.2e-17 62.5 0.0 2.2e-16 60.4 0.0 2.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Disintegrin PF00200.18 EWC48699.1 - 1.8e-15 56.8 24.9 1.8e-15 56.8 17.3 4.3 2 1 2 4 4 4 1 Disintegrin Reprolysin PF01421.14 EWC48699.1 - 1.3e-05 24.9 6.3 0.00051 19.6 4.4 2.8 1 1 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Aminotran_1_2 PF00155.16 EWC48700.1 - 1e-68 231.9 0.0 1.2e-68 231.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.12 EWC48700.1 - 0.0027 16.8 0.0 0.0053 15.8 0.0 1.4 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.16 EWC48700.1 - 0.014 14.5 0.0 0.021 13.9 0.0 1.2 1 0 0 1 1 1 0 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.15 EWC48700.1 - 0.016 13.4 0.0 0.027 12.7 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.14 EWC48700.1 - 0.08 11.6 0.0 0.14 10.8 0.0 1.4 1 0 0 1 1 1 0 Aminotransferase class-V TMEM171 PF15471.1 EWC48700.1 - 0.2 10.4 1.1 0.29 9.8 0.3 1.5 2 0 0 2 2 2 0 Transmembrane protein family 171 Uds1 PF15456.1 EWC48701.1 - 4e-24 84.9 4.0 4e-24 84.9 2.8 2.1 2 0 0 2 2 2 1 Up-regulated During Septation DUF1768 PF08719.6 EWC48702.1 - 1.6e-51 174.1 0.0 1.8e-51 173.9 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) DUF1919 PF08942.5 EWC48702.1 - 0.051 12.9 0.1 0.071 12.4 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1919) HbrB PF08539.6 EWC48703.1 - 2.7e-45 154.0 0.0 4.3e-45 153.3 0.0 1.2 1 0 0 1 1 1 1 HbrB-like AAA_17 PF13207.1 EWC48703.1 - 5.2e-05 24.0 0.0 0.00014 22.6 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.1 EWC48703.1 - 0.00029 20.9 0.0 0.5 10.5 0.0 2.7 3 0 0 3 3 3 2 AAA domain AAA_16 PF13191.1 EWC48703.1 - 0.001 19.1 0.4 0.03 14.3 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain AAA_18 PF13238.1 EWC48703.1 - 0.0022 18.2 0.0 0.16 12.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain PRK PF00485.13 EWC48703.1 - 0.015 14.8 0.0 0.039 13.4 0.0 1.7 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family AAA_28 PF13521.1 EWC48703.1 - 0.031 14.2 0.1 0.096 12.6 0.1 1.8 2 0 0 2 2 2 0 AAA domain Arch_ATPase PF01637.13 EWC48703.1 - 0.044 13.4 0.0 9.3 5.8 0.0 2.7 3 0 0 3 3 3 0 Archaeal ATPase LSM PF01423.17 EWC48704.1 - 0.0025 17.3 0.0 0.0042 16.6 0.0 1.4 1 0 0 1 1 1 1 LSM domain Elongin_A PF06881.6 EWC48704.1 - 0.022 15.1 0.0 0.027 14.8 0.0 1.1 1 0 0 1 1 1 0 RNA polymerase II transcription factor SIII (Elongin) subunit A Ribosomal_L3 PF00297.17 EWC48705.1 - 8.4e-118 392.4 5.0 1e-117 392.2 3.5 1.1 1 0 0 1 1 1 1 Ribosomal protein L3 TPR_1 PF00515.23 EWC48706.1 - 4.4e-50 165.3 31.1 3.9e-08 32.5 0.0 10.5 11 1 0 11 11 11 8 Tetratricopeptide repeat TPR_11 PF13414.1 EWC48706.1 - 4.2e-48 160.8 31.2 1.2e-13 50.4 1.2 6.6 2 2 5 8 8 8 8 TPR repeat TPR_2 PF07719.12 EWC48706.1 - 8.2e-43 140.9 24.0 1.4e-05 24.6 0.0 10.4 11 0 0 11 11 11 8 Tetratricopeptide repeat TPR_8 PF13181.1 EWC48706.1 - 4.3e-38 126.2 21.4 7.1e-06 25.4 0.6 10.3 8 1 2 10 10 10 8 Tetratricopeptide repeat TPR_16 PF13432.1 EWC48706.1 - 1.1e-27 96.0 11.0 2.1e-07 31.4 0.3 6.6 4 2 1 6 6 6 5 Tetratricopeptide repeat TPR_12 PF13424.1 EWC48706.1 - 2e-27 94.9 19.0 2.4e-06 27.3 1.4 7.1 1 1 8 9 9 9 9 Tetratricopeptide repeat TPR_17 PF13431.1 EWC48706.1 - 3.6e-26 89.1 17.0 0.0011 18.9 0.1 9.7 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_14 PF13428.1 EWC48706.1 - 2.1e-25 86.8 8.8 0.0013 19.1 0.0 9.7 2 2 8 10 10 10 8 Tetratricopeptide repeat TPR_19 PF14559.1 EWC48706.1 - 1.7e-20 73.0 13.5 3.5e-05 24.0 0.1 6.4 4 3 3 7 7 7 5 Tetratricopeptide repeat TPR_6 PF13174.1 EWC48706.1 - 4.5e-20 70.6 19.0 0.0082 16.5 0.0 9.3 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_7 PF13176.1 EWC48706.1 - 1.6e-18 64.9 16.2 0.0014 18.2 0.0 9.1 8 2 1 9 9 9 3 Tetratricopeptide repeat TPR_9 PF13371.1 EWC48706.1 - 8.9e-13 47.8 8.8 0.00074 19.3 0.1 6.6 4 2 3 7 7 7 3 Tetratricopeptide repeat Apc3 PF12895.2 EWC48706.1 - 6.3e-11 42.2 10.1 6.6e-08 32.5 1.0 4.2 3 2 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.1 EWC48706.1 - 9.7e-11 41.2 8.1 7.3e-06 25.2 1.4 4.3 1 1 3 4 4 4 3 Tetratricopeptide repeat TPR_21 PF09976.4 EWC48706.1 - 8.6e-05 22.5 11.8 0.24 11.3 0.9 5.0 5 1 1 6 6 6 3 Tetratricopeptide repeat DUF2225 PF09986.4 EWC48706.1 - 0.0043 16.5 5.0 0.48 9.8 0.1 3.0 2 1 2 4 4 4 2 Uncharacterized protein conserved in bacteria (DUF2225) TPR_20 PF14561.1 EWC48706.1 - 0.0055 16.7 5.6 0.26 11.4 0.0 4.3 4 2 1 5 5 4 1 Tetratricopeptide repeat TPR_10 PF13374.1 EWC48706.1 - 0.027 14.3 13.6 6.1 6.9 0.0 6.3 8 0 0 8 8 7 0 Tetratricopeptide repeat SNAP PF14938.1 EWC48706.1 - 0.17 11.0 15.4 9.1 5.3 0.3 4.9 1 1 3 4 4 4 0 Soluble NSF attachment protein, SNAP MIT PF04212.13 EWC48706.1 - 5.2 7.0 16.5 5.1 7.0 0.0 5.1 6 0 0 6 6 5 0 MIT (microtubule interacting and transport) domain Esterase_phd PF10503.4 EWC48707.1 - 5e-22 78.2 0.3 8.8e-22 77.4 0.2 1.4 1 0 0 1 1 1 1 Esterase PHB depolymerase CBM_1 PF00734.13 EWC48707.1 - 3.1e-10 39.5 8.9 3.1e-10 39.5 6.2 3.2 3 0 0 3 3 3 1 Fungal cellulose binding domain Abhydrolase_5 PF12695.2 EWC48707.1 - 1.1e-09 38.2 0.2 1.8e-09 37.4 0.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 EWC48707.1 - 3e-07 29.8 1.8 3e-07 29.8 1.3 1.6 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.2 EWC48707.1 - 4.3e-07 30.0 0.1 2e-06 27.8 0.1 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.15 EWC48707.1 - 5.8e-05 22.6 0.6 0.00012 21.6 0.4 1.5 1 0 0 1 1 1 1 Putative esterase Abhydrolase_1 PF00561.15 EWC48707.1 - 8.1e-05 22.2 0.0 0.0001 21.9 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.23 EWC48707.1 - 0.00011 21.1 0.3 0.00063 18.5 0.1 2.1 2 0 0 2 2 2 1 Carboxylesterase family Abhydrolase_2 PF02230.11 EWC48707.1 - 0.00075 19.0 0.1 0.005 16.3 0.1 2.1 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase FSH1 PF03959.8 EWC48707.1 - 0.0061 16.0 0.0 0.0099 15.3 0.0 1.4 1 0 0 1 1 1 1 Serine hydrolase (FSH1) DLH PF01738.13 EWC48707.1 - 0.041 13.1 0.0 0.072 12.3 0.0 1.4 1 0 0 1 1 1 0 Dienelactone hydrolase family Abhydrolase_3 PF07859.8 EWC48707.1 - 0.057 12.9 0.1 0.11 12.0 0.1 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold Pox_A32 PF04665.7 EWC48707.1 - 0.22 10.7 0.0 0.32 10.2 0.0 1.1 1 0 0 1 1 1 0 Poxvirus A32 protein Sporozoite_P67 PF05642.6 EWC48707.1 - 0.31 8.8 6.6 0.37 8.6 4.6 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen TraG-D_C PF12696.2 EWC48707.1 - 1.7 8.5 7.5 4 7.3 0.0 2.4 2 0 0 2 2 2 0 TraM recognition site of TraD and TraG Pex14_N PF04695.8 EWC48707.1 - 8.8 6.3 10.5 0.41 10.6 2.6 2.2 2 1 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region SKN1 PF03935.10 EWC48708.1 - 1.7e-216 719.2 0.0 2e-216 719.0 0.0 1.0 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) Nif11 PF07862.6 EWC48709.1 - 0.1 12.5 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 Nitrogen fixation protein of unknown function IMS PF00817.15 EWC48711.1 - 6.4e-24 84.4 0.0 1.2e-23 83.5 0.0 1.4 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.3 EWC48711.1 - 4.1e-07 29.9 0.1 8.3e-07 28.9 0.1 1.5 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.3 EWC48711.1 - 0.0046 16.9 0.1 0.012 15.6 0.1 1.7 1 0 0 1 1 1 1 IMS family HHH motif HAUS4 PF14735.1 EWC48712.1 - 8e-15 54.7 0.4 1.4e-14 54.0 0.3 1.3 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 4 Rep_fac_C PF08542.6 EWC48712.1 - 0.022 14.7 0.1 0.11 12.4 0.0 2.2 3 0 0 3 3 3 0 Replication factor C C-terminal domain DUF241 PF03087.9 EWC48712.1 - 0.056 12.9 3.6 0.045 13.2 0.9 2.0 1 1 1 2 2 2 0 Arabidopsis protein of unknown function Cortex-I_coil PF09304.5 EWC48712.1 - 3.6 7.6 9.5 1.3 9.1 0.2 3.0 2 1 0 3 3 3 0 Cortexillin I, coiled coil DUF4404 PF14357.1 EWC48712.1 - 3.7 8.0 12.6 2.4 8.6 0.5 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4404) SART-1 PF03343.8 EWC48713.1 - 9.5e-158 526.2 54.6 6.3e-149 497.1 35.8 2.0 2 0 0 2 2 2 2 SART-1 family PTH2 PF01981.11 EWC48714.1 - 5e-47 158.3 0.3 6.2e-47 158.0 0.2 1.1 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 Aminotran_1_2 PF00155.16 EWC48715.1 - 3.1e-85 286.2 0.0 3.5e-85 286.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Hpt PF01627.18 EWC48716.1 - 7.2e-13 48.3 0.5 1e-12 47.9 0.1 1.4 2 0 0 2 2 2 1 Hpt domain ADP_ribosyl_GH PF03747.9 EWC48717.1 - 5.5e-63 213.4 0.2 7.9e-63 212.9 0.2 1.2 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase Ald_Xan_dh_C2 PF02738.13 EWC48718.1 - 1.4e-196 654.0 1.2 1.9e-196 653.6 0.9 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.16 EWC48718.1 - 2.7e-45 153.8 0.0 5e-45 152.9 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase CO_deh_flav_C PF03450.12 EWC48718.1 - 6.9e-32 109.4 0.1 3.2e-31 107.3 0.0 2.3 2 0 0 2 2 2 1 CO dehydrogenase flavoprotein C-terminal domain Ald_Xan_dh_C PF01315.17 EWC48718.1 - 1e-31 109.2 0.0 2.3e-31 108.1 0.0 1.6 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain Fer2_2 PF01799.15 EWC48718.1 - 1.2e-29 101.9 0.0 2.6e-29 100.9 0.0 1.6 1 0 0 1 1 1 1 [2Fe-2S] binding domain Fer2 PF00111.22 EWC48718.1 - 5.6e-09 35.6 0.7 1.4e-08 34.3 0.1 2.1 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain CAP PF00188.21 EWC48719.1 - 6.6e-18 65.3 1.4 8.7e-18 64.9 1.0 1.2 1 0 0 1 1 1 1 Cysteine-rich secretory protein family ATP-synt_ab PF00006.20 EWC48720.1 - 3.5e-61 206.4 0.0 4.6e-61 206.0 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 EWC48720.1 - 5.6e-17 62.2 0.1 1e-16 61.3 0.0 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.18 EWC48720.1 - 5.4e-13 48.9 1.9 6.3e-13 48.7 0.5 1.8 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain HAS-barrel PF09378.5 EWC48720.1 - 0.00038 20.2 0.3 0.0009 19.0 0.2 1.6 1 0 0 1 1 1 1 HAS barrel domain Trp_syntA PF00290.15 EWC48721.1 - 1.2e-89 299.2 1.1 1.7e-89 298.7 0.1 1.6 2 0 0 2 2 2 1 Tryptophan synthase alpha chain PALP PF00291.20 EWC48721.1 - 3.7e-43 147.9 0.4 6.5e-43 147.0 0.3 1.4 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DUF2191 PF09957.4 EWC48721.1 - 0.0069 16.1 0.0 4 7.3 0.0 2.6 2 0 0 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2191) DFP PF04127.10 EWC48721.1 - 0.057 13.0 0.2 0.62 9.6 0.1 2.3 2 0 0 2 2 2 0 DNA / pantothenate metabolism flavoprotein Aminotran_3 PF00202.16 EWC48722.1 - 9.8e-89 297.5 0.0 1.4e-88 296.9 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-III TIP49 PF06068.8 EWC48723.1 - 3.9e-186 618.5 0.5 4.7e-186 618.2 0.3 1.1 1 0 0 1 1 1 1 TIP49 C-terminus RuvB_N PF05496.7 EWC48723.1 - 2.7e-14 52.7 1.8 1e-08 34.5 0.0 2.9 2 1 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus AAA PF00004.24 EWC48723.1 - 1.9e-11 44.2 0.3 5.8e-07 29.7 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 EWC48723.1 - 2.4e-07 30.9 0.0 5e-05 23.3 0.0 2.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 EWC48723.1 - 7.8e-05 22.8 0.1 0.26 11.4 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.1 EWC48723.1 - 0.0001 21.9 1.0 0.00026 20.7 0.1 2.1 2 0 0 2 2 2 1 Part of AAA domain AAA_28 PF13521.1 EWC48723.1 - 0.00049 20.0 0.4 0.0017 18.3 0.1 2.0 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.9 EWC48723.1 - 0.00071 19.3 0.2 0.15 11.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.21 EWC48723.1 - 0.0012 18.3 0.1 0.88 9.0 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_25 PF13481.1 EWC48723.1 - 0.0013 18.1 0.0 0.0024 17.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.16 EWC48723.1 - 0.0021 17.2 0.2 0.1 11.7 0.1 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.7 EWC48723.1 - 0.0022 17.0 0.4 0.0059 15.7 0.3 1.6 1 0 0 1 1 1 1 Zeta toxin DnaB_C PF03796.10 EWC48723.1 - 0.0079 15.0 0.0 0.015 14.1 0.0 1.4 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_14 PF13173.1 EWC48723.1 - 0.0091 15.9 0.0 0.39 10.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.12 EWC48723.1 - 0.017 14.5 0.2 0.039 13.3 0.1 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein Bac_DnaA PF00308.13 EWC48723.1 - 0.019 14.5 0.1 6.5 6.3 0.0 2.3 2 0 0 2 2 2 0 Bacterial dnaA protein AAA_18 PF13238.1 EWC48723.1 - 0.022 15.0 0.2 0.14 12.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain KaiC PF06745.8 EWC48723.1 - 0.031 13.4 0.4 0.15 11.1 0.0 2.0 2 0 0 2 2 2 0 KaiC DUF2075 PF09848.4 EWC48723.1 - 0.043 12.8 0.1 0.076 11.9 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) MinE PF03776.9 EWC48723.1 - 0.098 12.1 0.1 0.28 10.7 0.1 1.7 1 0 0 1 1 1 0 Septum formation topological specificity factor MinE PhoH PF02562.11 EWC48723.1 - 0.24 10.6 0.1 0.24 10.6 0.1 2.0 3 0 0 3 3 3 0 PhoH-like protein HMG_box PF00505.14 EWC48724.1 - 2.1e-13 50.3 2.5 4.1e-13 49.3 1.7 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 EWC48724.1 - 0.045 14.1 0.8 0.082 13.2 0.6 1.4 1 0 0 1 1 1 0 HMG-box domain Zip PF02535.17 EWC48724.1 - 0.77 8.7 5.8 1.2 8.1 4.0 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter SelP_N PF04592.9 EWC48724.1 - 6.9 5.9 14.4 1 8.6 6.4 2.0 2 0 0 2 2 2 0 Selenoprotein P, N terminal region MgsA_C PF12002.3 EWC48725.1 - 1e-53 181.4 0.1 4.1e-53 179.5 0.0 2.0 2 0 0 2 2 2 1 MgsA AAA+ ATPase C terminal AAA PF00004.24 EWC48725.1 - 2e-07 31.2 0.0 3.5e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.1 EWC48725.1 - 0.00022 20.9 0.3 0.0012 18.5 0.0 2.3 2 0 0 2 2 2 1 Part of AAA domain RuvB_N PF05496.7 EWC48725.1 - 0.00023 20.3 0.0 0.00035 19.6 0.0 1.2 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus Rad17 PF03215.10 EWC48725.1 - 0.00075 18.2 0.0 0.14 10.7 0.0 2.1 2 0 0 2 2 2 2 Rad17 cell cycle checkpoint protein AAA_5 PF07728.9 EWC48725.1 - 0.00094 18.9 0.0 0.0022 17.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 EWC48725.1 - 0.0015 18.5 0.2 0.027 14.4 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain zf-C2HC_2 PF13913.1 EWC48725.1 - 0.0058 16.2 0.7 0.051 13.2 0.1 2.5 2 0 0 2 2 2 1 zinc-finger of a C2HC-type AAA_28 PF13521.1 EWC48725.1 - 0.011 15.6 0.2 0.023 14.6 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.1 EWC48725.1 - 0.013 15.6 0.0 0.035 14.2 0.0 1.7 1 1 0 1 1 1 0 AAA domain Sgf11 PF08209.6 EWC48725.1 - 0.02 14.2 0.1 0.042 13.1 0.1 1.5 1 0 0 1 1 1 0 Sgf11 (transcriptional regulation protein) Zeta_toxin PF06414.7 EWC48725.1 - 0.026 13.6 0.0 0.054 12.5 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin SKI PF01202.17 EWC48725.1 - 0.051 13.4 0.0 0.1 12.4 0.0 1.5 1 0 0 1 1 1 0 Shikimate kinase AAA_17 PF13207.1 EWC48725.1 - 0.065 14.0 0.0 0.32 11.8 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.1 EWC48725.1 - 0.067 13.4 0.0 0.13 12.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.16 EWC48725.1 - 0.069 12.3 0.0 0.12 11.5 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI NB-ARC PF00931.17 EWC48725.1 - 0.078 11.8 0.0 0.12 11.1 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain AAA_3 PF07726.6 EWC48725.1 - 0.1 12.2 0.0 1.3 8.5 0.0 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.22 EWC48725.1 - 0.11 12.7 0.0 0.22 11.8 0.0 1.5 1 0 0 1 1 1 0 ABC transporter Viral_helicase1 PF01443.13 EWC48725.1 - 0.17 11.3 0.0 0.29 10.5 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase NTPase_1 PF03266.10 EWC48725.1 - 0.19 11.4 0.1 0.3 10.7 0.1 1.3 1 0 0 1 1 1 0 NTPase RNA_helicase PF00910.17 EWC48725.1 - 0.19 11.8 0.0 0.37 10.9 0.0 1.4 1 0 0 1 1 1 0 RNA helicase TIP49 PF06068.8 EWC48725.1 - 0.25 10.0 0.0 0.4 9.3 0.0 1.2 1 0 0 1 1 1 0 TIP49 C-terminus S10_plectin PF03501.10 EWC48726.1 - 4.6e-41 138.5 0.4 5.5e-41 138.3 0.3 1.1 1 0 0 1 1 1 1 Plectin/S10 domain Telomere_Sde2 PF13019.1 EWC48727.1 - 1.6e-58 196.9 0.2 2.2e-58 196.5 0.2 1.1 1 0 0 1 1 1 1 Telomere stability and silencing AMP-binding PF00501.23 EWC48728.1 - 1.5e-72 244.3 0.1 1.9e-72 243.9 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 EWC48728.1 - 2.9e-17 63.3 0.0 6.8e-17 62.1 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Ribosomal_L1 PF00687.16 EWC48729.1 - 5.4e-51 173.0 1.5 6.2e-51 172.8 1.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Aldo_ket_red PF00248.16 EWC48730.1 - 1.4e-43 148.7 0.0 1.6e-43 148.5 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family DUF3343 PF11823.3 EWC48730.1 - 0.064 12.5 0.0 0.19 10.9 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3343) CK_II_beta PF01214.13 EWC48731.1 - 2.4e-72 242.3 0.0 4e-72 241.6 0.0 1.4 1 0 0 1 1 1 1 Casein kinase II regulatory subunit Daxx PF03344.10 EWC48731.1 - 5.8 5.2 11.2 7.8 4.8 7.7 1.2 1 0 0 1 1 1 0 Daxx Family SLAC1 PF03595.12 EWC48732.1 - 1.7e-92 309.6 56.1 1.9e-92 309.4 38.9 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel bZIP_1 PF00170.16 EWC48733.1 - 6e-05 22.9 6.1 0.00013 21.8 4.2 1.5 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 EWC48733.1 - 0.0015 18.3 4.8 0.0015 18.3 3.3 1.9 2 0 0 2 2 2 1 Basic region leucine zipper PAT1 PF09770.4 EWC48733.1 - 7.2 4.7 26.0 0.55 8.4 14.4 1.6 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Mucin PF01456.12 EWC48734.1 - 0.0076 16.0 0.2 0.0076 16.0 0.1 3.8 3 0 0 3 3 3 2 Mucin-like glycoprotein Potex_coat PF06184.6 EWC48734.1 - 0.0081 15.5 0.1 0.017 14.4 0.1 1.5 1 0 0 1 1 1 1 Potexvirus coat protein DUF719 PF05334.8 EWC48734.1 - 0.92 9.5 4.5 4.1 7.4 1.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF719) CIA30 PF08547.7 EWC48735.1 - 1.3e-28 99.8 0.0 2.2e-28 99.1 0.0 1.3 1 0 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) TENA_THI-4 PF03070.11 EWC48736.1 - 0.051 13.3 0.0 0.15 11.7 0.0 1.8 2 0 0 2 2 2 0 TENA/THI-4/PQQC family Zip PF02535.17 EWC48737.1 - 1.2e-25 90.1 54.4 1.7e-12 46.9 4.3 4.8 2 1 3 5 5 5 4 ZIP Zinc transporter DUF2457 PF10446.4 EWC48737.1 - 0.93 8.1 10.7 1.8 7.1 7.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Reo_sigmaC PF04582.7 EWC48739.1 - 0.00013 21.3 3.0 0.00013 21.3 2.1 2.3 3 0 0 3 3 3 1 Reovirus sigma C capsid protein PAM2 PF07145.10 EWC48739.1 - 0.0055 16.1 0.1 0.0055 16.1 0.1 3.4 3 0 0 3 3 3 1 Ataxin-2 C-terminal region Pkinase PF00069.20 EWC48740.1 - 4.3e-21 75.2 0.0 2.7e-20 72.6 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC48740.1 - 3.3e-15 55.8 0.0 3.6e-14 52.4 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.9 EWC48740.1 - 0.032 13.2 0.0 5.5 5.9 0.0 2.3 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family START PF01852.14 EWC48741.1 - 8.9e-06 25.1 0.0 1.3e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 START domain DUF4198 PF10670.4 EWC48741.1 - 0.08 12.9 1.1 0.15 12.0 0.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4198) PipA PF07108.6 EWC48741.1 - 0.1 11.9 0.0 0.15 11.4 0.0 1.2 1 0 0 1 1 1 0 PipA protein Zn_clus PF00172.13 EWC48742.1 - 8e-11 41.6 15.1 1.3e-10 41.0 10.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 EWC48742.1 - 4.1e-05 22.6 0.1 7.3e-05 21.7 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain CMD PF02627.15 EWC48743.1 - 0.013 15.3 0.0 0.031 14.1 0.0 1.6 1 0 0 1 1 1 0 Carboxymuconolactone decarboxylase family Pyr_redox_3 PF13738.1 EWC48744.1 - 7.4e-24 84.9 0.0 3e-23 82.9 0.0 2.0 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.14 EWC48744.1 - 1.2e-16 60.0 0.0 4.3e-13 48.3 0.0 2.2 2 0 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.9 EWC48744.1 - 2.9e-10 40.3 0.0 8.2e-05 22.5 0.0 2.8 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 EWC48744.1 - 5.3e-08 32.1 0.0 1.1e-05 24.5 0.0 3.0 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Shikimate_DH PF01488.15 EWC48744.1 - 7.3e-06 26.1 0.0 0.0016 18.5 0.0 2.3 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.14 EWC48744.1 - 4.3e-05 22.7 0.0 0.17 11.0 0.0 2.3 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TrkA_N PF02254.13 EWC48744.1 - 0.00018 21.4 0.0 0.92 9.5 0.0 2.5 2 0 0 2 2 2 2 TrkA-N domain Pyr_redox PF00070.22 EWC48744.1 - 0.0005 20.4 0.0 0.097 13.0 0.0 3.0 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 EWC48744.1 - 0.00054 19.9 0.0 0.0039 17.1 0.0 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.14 EWC48744.1 - 0.00066 18.8 0.0 1.5 7.7 0.0 2.9 3 0 0 3 3 3 2 FAD binding domain Lycopene_cycl PF05834.7 EWC48744.1 - 0.00076 18.4 0.2 0.052 12.4 0.0 2.7 3 0 0 3 3 3 1 Lycopene cyclase protein GIDA PF01134.17 EWC48744.1 - 0.0017 17.2 0.1 0.43 9.3 0.2 2.5 2 1 0 2 2 2 1 Glucose inhibited division protein A 3HCDH_N PF02737.13 EWC48744.1 - 0.0019 17.8 0.0 0.062 12.9 0.0 2.4 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DAO PF01266.19 EWC48744.1 - 0.0061 15.5 0.1 3.6 6.4 0.0 3.2 4 0 0 4 4 4 1 FAD dependent oxidoreductase HI0933_like PF03486.9 EWC48744.1 - 0.0069 14.9 0.1 0.27 9.6 0.0 2.8 3 0 0 3 3 3 1 HI0933-like protein NAD_binding_7 PF13241.1 EWC48744.1 - 0.011 15.9 0.0 0.17 12.1 0.0 2.3 2 0 0 2 2 2 0 Putative NAD(P)-binding AlaDh_PNT_C PF01262.16 EWC48744.1 - 0.02 14.4 0.0 3 7.3 0.0 2.2 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_2 PF00890.19 EWC48744.1 - 0.023 13.5 0.1 0.27 10.0 0.0 2.3 2 1 0 2 2 2 0 FAD binding domain IlvN PF07991.7 EWC48744.1 - 0.043 13.1 0.0 0.078 12.3 0.0 1.4 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, catalytic domain ApbA PF02558.11 EWC48744.1 - 0.1 12.0 0.0 1.6 8.1 0.0 2.4 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA ThiF PF00899.16 EWC48744.1 - 0.16 11.7 0.1 0.67 9.7 0.0 1.9 2 0 0 2 2 2 0 ThiF family RTA1 PF04479.8 EWC48745.1 - 5.8e-47 160.0 9.5 8e-47 159.6 6.6 1.1 1 0 0 1 1 1 1 RTA1 like protein DUF3309 PF11752.3 EWC48745.1 - 0.017 14.9 0.9 0.041 13.6 0.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3309) PalH PF08733.5 EWC48745.1 - 0.06 12.1 5.3 0.049 12.4 3.0 1.4 1 1 0 1 1 1 0 PalH/RIM21 DUF3425 PF11905.3 EWC48746.1 - 1.9e-27 95.8 0.9 3.6e-27 94.9 0.3 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3425) bZIP_1 PF00170.16 EWC48746.1 - 0.088 12.7 3.0 0.15 12.0 2.1 1.3 1 0 0 1 1 1 0 bZIP transcription factor Rhomboid PF01694.17 EWC48747.1 - 1.7e-21 76.7 17.9 1.7e-21 76.7 12.4 2.1 2 0 0 2 2 2 1 Rhomboid family Hpre_diP_synt_I PF07456.6 EWC48747.1 - 0.043 13.6 5.3 0.076 12.8 3.7 1.3 1 0 0 1 1 1 0 Heptaprenyl diphosphate synthase component I Apt1 PF10351.4 EWC48748.1 - 0.038 12.8 12.8 0.67 8.7 10.0 1.8 2 0 0 2 2 2 0 Golgi-body localisation protein domain Trypsin_2 PF13365.1 EWC48748.1 - 0.048 13.6 2.6 0.98 9.4 1.0 2.3 2 0 0 2 2 2 0 Trypsin-like peptidase domain Menin PF05053.8 EWC48748.1 - 0.74 7.9 8.0 1.2 7.2 5.5 1.2 1 0 0 1 1 1 0 Menin Macoilin PF09726.4 EWC48748.1 - 1 7.5 16.2 1.3 7.2 11.2 1.1 1 0 0 1 1 1 0 Transmembrane protein DUF2217 PF10265.4 EWC48748.1 - 2.4 6.8 12.0 3.4 6.3 8.3 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) DUF572 PF04502.8 EWC48748.1 - 3.7 6.6 6.1 5.1 6.2 4.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) RAP1 PF07218.6 EWC48748.1 - 4.8 5.1 26.1 6.4 4.7 18.1 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF566 PF04484.7 EWC48748.1 - 5.2 6.4 18.3 7.9 5.8 12.7 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF566) DUF4614 PF15391.1 EWC48748.1 - 5.5 6.7 19.1 12 5.6 13.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) Sec3_C PF09763.4 EWC48748.1 - 7.9 4.4 8.2 10 4.0 5.7 1.1 1 0 0 1 1 1 0 Exocyst complex component Sec3 TrbC PF04956.8 EWC48751.1 - 0.024 14.6 0.3 0.024 14.6 0.2 1.9 2 0 0 2 2 2 0 TrbC/VIRB2 family DUF4229 PF14012.1 EWC48751.1 - 0.08 12.8 0.1 0.3 10.9 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4229) Rifin_STEVOR PF02009.11 EWC48751.1 - 0.14 11.7 0.3 0.2 11.2 0.2 1.2 1 0 0 1 1 1 0 Rifin/stevor family DUF4233 PF14017.1 EWC48752.1 - 0.0026 17.6 0.7 0.0042 17.0 0.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4233) adh_short PF00106.20 EWC48753.1 - 5e-11 42.7 0.0 1.7e-10 41.0 0.0 1.7 1 1 0 2 2 2 1 short chain dehydrogenase KR PF08659.5 EWC48753.1 - 1.3e-05 24.9 0.0 2.3e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 KR domain Eno-Rase_NADH_b PF12242.3 EWC48753.1 - 0.0037 17.0 0.1 0.011 15.4 0.1 1.8 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase 3Beta_HSD PF01073.14 EWC48753.1 - 0.075 11.7 0.0 0.11 11.1 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family SpecificRecomb PF10136.4 EWC48754.1 - 0.11 10.5 0.4 0.14 10.1 0.3 1.1 1 0 0 1 1 1 0 Site-specific recombinase DUF3336 PF11815.3 EWC48755.1 - 6.8e-38 129.4 0.0 1.5e-37 128.3 0.0 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF3336) Patatin PF01734.17 EWC48755.1 - 1e-14 55.0 0.3 2.1e-14 53.9 0.1 1.7 1 1 0 1 1 1 1 Patatin-like phospholipase SURF4 PF02077.10 EWC48756.1 - 6.5e-100 333.9 6.7 7.3e-100 333.7 4.7 1.0 1 0 0 1 1 1 1 SURF4 family NMN_transporter PF04973.7 EWC48756.1 - 0.22 10.9 8.9 0.4 10.1 6.1 1.4 1 0 0 1 1 1 0 Nicotinamide mononucleotide transporter PepSY_TM_2 PF13703.1 EWC48756.1 - 1.9 8.7 15.7 0.16 12.1 2.5 3.6 1 1 1 2 2 2 0 PepSY-associated TM helix FA_desaturase PF00487.19 EWC48756.1 - 4.8 6.5 8.3 3.8 6.8 4.2 1.9 1 1 1 2 2 2 0 Fatty acid desaturase Tho2 PF11262.3 EWC48757.1 - 1.7 7.6 5.1 2.7 6.9 3.6 1.2 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 CHORD PF04968.7 EWC48758.1 - 2.3e-51 171.9 18.4 9.1e-26 89.9 4.4 2.3 2 0 0 2 2 2 2 CHORD CS PF04969.11 EWC48758.1 - 1e-12 48.4 0.0 1.5e-12 47.9 0.0 1.3 1 0 0 1 1 1 1 CS domain BTK PF00779.14 EWC48758.1 - 0.17 11.5 5.3 3.7 7.2 0.1 3.1 2 0 0 2 2 2 0 BTK motif DUF3712 PF12505.3 EWC48759.1 - 8.1e-22 77.5 0.4 8.1e-22 77.5 0.3 2.0 3 0 0 3 3 3 1 Protein of unknown function (DUF3712) Pyr_redox_3 PF13738.1 EWC48760.1 - 1.1e-26 94.2 0.0 2.7e-24 86.3 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 EWC48760.1 - 5.6e-10 39.1 0.0 1.2e-09 38.0 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 EWC48760.1 - 1.1e-07 31.1 0.0 0.00073 18.5 0.0 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_9 PF13454.1 EWC48760.1 - 1.3e-07 31.4 1.0 0.011 15.4 0.0 3.3 3 0 0 3 3 3 2 FAD-NAD(P)-binding FMO-like PF00743.14 EWC48760.1 - 3.3e-06 25.5 0.1 0.00013 20.3 0.0 2.8 2 1 0 2 2 2 1 Flavin-binding monooxygenase-like Shikimate_DH PF01488.15 EWC48760.1 - 0.00023 21.2 0.0 0.22 11.6 0.0 2.7 3 0 0 3 3 3 2 Shikimate / quinate 5-dehydrogenase K_oxygenase PF13434.1 EWC48760.1 - 0.00044 19.2 0.1 2.6 6.8 0.0 3.9 3 1 1 4 4 4 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.9 EWC48760.1 - 0.0025 17.7 0.0 0.18 11.6 0.0 2.5 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 EWC48760.1 - 0.0033 16.5 0.2 0.01 14.9 0.0 1.8 2 0 0 2 2 2 1 Thi4 family GIDA PF01134.17 EWC48760.1 - 0.0049 15.7 0.3 0.35 9.6 0.0 2.3 2 0 0 2 2 2 1 Glucose inhibited division protein A FAD_binding_2 PF00890.19 EWC48760.1 - 0.013 14.3 0.1 0.034 13.0 0.0 1.7 2 0 0 2 2 2 0 FAD binding domain FAD_binding_3 PF01494.14 EWC48760.1 - 0.024 13.7 0.1 0.047 12.7 0.1 1.5 1 0 0 1 1 1 0 FAD binding domain HI0933_like PF03486.9 EWC48760.1 - 0.079 11.4 0.8 1.9 6.8 0.2 2.4 2 0 0 2 2 2 0 HI0933-like protein Amino_oxidase PF01593.19 EWC48760.1 - 0.089 11.8 0.0 0.93 8.4 0.0 2.2 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase Zn_clus PF00172.13 EWC48761.1 - 1e-09 38.1 6.2 2.7e-09 36.7 4.3 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Mito_fiss_reg PF05308.6 EWC48761.1 - 8.5 5.6 8.9 13 5.0 3.8 2.1 2 0 0 2 2 2 0 Mitochondrial fission regulator AA_permease PF00324.16 EWC48762.1 - 5.1e-106 354.8 41.4 6.3e-106 354.5 28.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EWC48762.1 - 5.3e-23 81.2 43.1 6.6e-23 80.9 29.9 1.0 1 0 0 1 1 1 1 Amino acid permease UPF0261 PF06792.6 EWC48762.1 - 0.062 11.7 0.1 0.093 11.1 0.1 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0261) MtrG PF04210.8 EWC48762.1 - 0.72 9.5 2.5 4.8 6.9 0.0 2.9 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, subunit G Catalase PF00199.14 EWC48763.1 - 6.8e-157 522.0 0.2 2.8e-156 520.0 0.1 1.8 1 1 0 1 1 1 1 Catalase Catalase-rel PF06628.7 EWC48763.1 - 1.6e-16 59.8 0.1 6.8e-16 57.8 0.0 2.1 3 0 0 3 3 3 1 Catalase-related immune-responsive PUL PF08324.6 EWC48763.1 - 0.29 9.8 0.0 0.46 9.2 0.0 1.2 1 0 0 1 1 1 0 PUL domain Fungal_trans PF04082.13 EWC48764.1 - 8.5e-15 54.3 0.1 1.5e-14 53.5 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EWC48764.1 - 1.2e-06 28.3 11.0 2.3e-06 27.4 7.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Rapamycin_bind PF08771.6 EWC48764.1 - 0.48 10.5 2.6 21 5.2 0.0 2.7 2 1 0 2 2 2 0 Rapamycin binding domain Exo_endo_phos PF03372.18 EWC48765.1 - 5e-17 62.6 1.3 7.2e-17 62.1 0.9 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.1 EWC48765.1 - 0.0059 16.2 1.4 0.052 13.1 0.1 2.8 2 1 0 2 2 2 1 Endonuclease-reverse transcriptase GSH_synth_ATP PF03917.12 EWC48766.1 - 0.088 11.3 0.0 0.11 11.0 0.0 1.0 1 0 0 1 1 1 0 Eukaryotic glutathione synthase, ATP binding domain CRAL_TRIO PF00650.15 EWC48767.1 - 1.6e-24 86.2 0.0 2.3e-24 85.6 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.10 EWC48767.1 - 0.002 18.2 0.0 0.0089 16.1 0.0 2.2 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain Peptidase_M22 PF00814.20 EWC48768.1 - 0.02 14.4 0.0 0.02 14.3 0.0 1.1 1 0 0 1 1 1 0 Glycoprotease family IncA PF04156.9 EWC48768.1 - 0.047 13.2 0.3 0.051 13.1 0.2 1.1 1 0 0 1 1 1 0 IncA protein Pro-kuma_activ PF09286.6 EWC48769.1 - 2.5e-47 160.5 0.1 4.4e-45 153.2 0.0 2.4 2 0 0 2 2 2 2 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.17 EWC48769.1 - 1.8e-06 27.3 1.1 3.1e-06 26.5 0.7 1.4 1 0 0 1 1 1 1 Subtilase family DUF904 PF06005.7 EWC48770.1 - 0.023 14.9 1.6 0.79 10.0 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF904) TFIIF_alpha PF05793.7 EWC48770.1 - 0.16 10.3 17.4 0.24 9.7 12.1 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Pyr_redox_3 PF13738.1 EWC48772.1 - 6.6e-24 85.1 0.0 1.1e-23 84.3 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.14 EWC48772.1 - 3.7e-16 58.4 1.0 8.4e-14 50.6 0.1 2.5 2 1 0 2 2 2 2 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.1 EWC48772.1 - 5.8e-11 42.2 0.0 1.2e-10 41.2 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 EWC48772.1 - 4.1e-07 29.8 0.6 1.7e-05 24.6 0.0 3.2 4 0 0 4 4 4 1 FAD-NAD(P)-binding K_oxygenase PF13434.1 EWC48772.1 - 4.5e-07 29.1 0.0 8.4e-05 21.6 0.0 3.0 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.9 EWC48772.1 - 2.6e-05 24.2 0.0 6.1e-05 22.9 0.0 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 EWC48772.1 - 0.00037 19.5 0.0 0.19 10.5 0.0 2.4 2 0 0 2 2 2 2 FAD dependent oxidoreductase Thi4 PF01946.12 EWC48772.1 - 0.014 14.4 0.1 0.19 10.7 0.0 2.2 2 0 0 2 2 2 0 Thi4 family FAD_binding_2 PF00890.19 EWC48772.1 - 0.042 12.6 0.0 0.08 11.7 0.0 1.5 1 0 0 1 1 1 0 FAD binding domain CoA_binding PF02629.14 EWC48772.1 - 0.071 13.6 0.1 7.9 7.0 0.0 2.4 2 0 0 2 2 2 0 CoA binding domain HI0933_like PF03486.9 EWC48772.1 - 0.16 10.3 0.0 0.25 9.7 0.0 1.3 1 0 0 1 1 1 0 HI0933-like protein Atrophin-1 PF03154.10 EWC48773.1 - 0.44 8.6 19.1 0.52 8.3 13.2 1.2 1 0 0 1 1 1 0 Atrophin-1 family DUF2146 PF10220.4 EWC48773.1 - 0.78 7.6 6.4 0.96 7.3 4.4 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2146) FLO_LFY PF01698.11 EWC48773.1 - 0.79 8.5 6.1 1 8.1 4.2 1.2 1 0 0 1 1 1 0 Floricaula / Leafy protein DDHD PF02862.12 EWC48773.1 - 1.5 8.5 8.0 2.3 7.9 5.6 1.3 1 0 0 1 1 1 0 DDHD domain DUF3827 PF12877.2 EWC48773.1 - 1.8 6.5 9.1 1.9 6.4 6.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) SR-25 PF10500.4 EWC48773.1 - 5.4 6.4 34.0 11 5.4 23.4 1.5 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein LCD1 PF09798.4 EWC48773.1 - 5.7 4.8 5.9 7.9 4.3 4.1 1.2 1 0 0 1 1 1 0 DNA damage checkpoint protein Apt1 PF10351.4 EWC48773.1 - 7.2 5.3 10.6 10 4.8 7.4 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Sugar_tr PF00083.19 EWC48774.1 - 5.4e-88 295.5 23.5 6.1e-88 295.3 16.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EWC48774.1 - 3.4e-29 101.6 23.2 3.6e-29 101.6 11.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 EWC48774.1 - 5e-06 25.1 4.9 5e-06 25.1 3.4 3.3 2 2 2 4 4 4 3 MFS/sugar transport protein APOC4 PF15119.1 EWC48775.1 - 0.033 14.1 0.1 0.093 12.7 0.1 1.7 2 0 0 2 2 2 0 Apolipoprotein C4 PRELI PF04707.9 EWC48776.1 - 1.3e-31 109.3 0.3 2.2e-30 105.3 0.2 2.0 2 0 0 2 2 2 1 PRELI-like family DUF77 PF01910.12 EWC48776.1 - 0.016 14.8 0.1 0.032 13.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function DUF77 EMP24_GP25L PF01105.19 EWC48777.1 - 1.5e-43 148.6 0.0 2e-43 148.2 0.0 1.2 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD TFIIF_alpha PF05793.7 EWC48777.1 - 0.064 11.6 0.4 0.085 11.2 0.3 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF4611 PF15387.1 EWC48777.1 - 0.19 11.8 7.3 0.3 11.2 2.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) Nucleoplasmin PF03066.10 EWC48777.1 - 0.3 10.6 2.1 0.59 9.6 1.5 1.4 1 0 0 1 1 1 0 Nucleoplasmin Sigma70_ner PF04546.8 EWC48777.1 - 0.64 9.5 5.8 1.8 8.1 1.4 2.1 2 0 0 2 2 2 0 Sigma-70, non-essential region tRNA-synt_1b PF00579.20 EWC48778.1 - 8.5e-21 74.3 0.0 1.6e-20 73.4 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) CBM_1 PF00734.13 EWC48779.1 - 2.5e-15 55.8 10.4 6.3e-15 54.5 7.2 1.8 1 0 0 1 1 1 1 Fungal cellulose binding domain Glyco_hydro_16 PF00722.16 EWC48779.1 - 7.6e-12 44.8 7.1 7.6e-12 44.8 5.0 1.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 16 SH3_1 PF00018.23 EWC48780.1 - 1e-14 53.6 0.0 1.7e-14 52.9 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 EWC48780.1 - 8.4e-12 44.4 0.0 1.4e-11 43.7 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 EWC48780.1 - 5.3e-07 29.0 0.0 7.9e-07 28.4 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain GFA PF04828.9 EWC48781.1 - 3.6e-07 30.0 0.2 0.041 13.8 0.2 2.4 2 0 0 2 2 2 2 Glutathione-dependent formaldehyde-activating enzyme Cwf_Cwc_15 PF04889.7 EWC48781.1 - 0.096 12.3 1.6 0.2 11.3 1.1 1.5 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CH PF00307.26 EWC48782.1 - 2.6e-12 46.7 0.0 4.6e-12 45.9 0.0 1.4 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.3 EWC48782.1 - 0.03 13.9 0.1 0.062 12.9 0.1 1.4 1 0 0 1 1 1 0 CAMSAP CH domain CDC24 PF06395.6 EWC48782.1 - 0.038 14.0 0.0 0.075 13.0 0.0 1.4 1 0 0 1 1 1 0 CDC24 Calponin 2OG-FeII_Oxy_3 PF13640.1 EWC48786.1 - 2.3e-09 37.6 0.0 4.6e-09 36.7 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Activator_LAG-3 PF11498.3 EWC48787.1 - 0.045 12.4 17.1 0.075 11.7 11.9 1.4 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Trypan_PARP PF05887.6 EWC48787.1 - 6 6.6 13.7 28 4.5 9.5 2.1 1 1 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) WH2 PF02205.15 EWC48788.1 - 7.7e-11 41.2 0.9 7.7e-11 41.2 0.6 2.1 2 0 0 2 2 2 1 WH2 motif CAP59_mtransfer PF11735.3 EWC48789.1 - 2.1e-83 279.2 0.0 2.6e-83 278.9 0.0 1.1 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 Mito_fiss_reg PF05308.6 EWC48791.1 - 0.049 13.0 1.3 0.059 12.7 0.9 1.1 1 0 0 1 1 1 0 Mitochondrial fission regulator SSP160 PF06933.6 EWC48791.1 - 0.072 11.0 10.5 0.077 10.9 7.3 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 CAP_N PF01213.14 EWC48791.1 - 1.6 7.9 4.2 2 7.6 2.9 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal MSP1_C PF07462.6 EWC48791.1 - 7 4.9 8.7 8.1 4.6 6.0 1.0 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus DUF3237 PF11578.3 EWC48792.1 - 1.4e-31 108.7 0.0 1.6e-31 108.6 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3237) F-box-like PF12937.2 EWC48793.1 - 0.006 16.2 0.1 0.006 16.2 0.1 2.2 3 0 0 3 3 3 1 F-box-like F-box PF00646.28 EWC48793.1 - 0.012 15.2 0.0 0.032 13.8 0.0 1.7 1 0 0 1 1 1 0 F-box domain LSM PF01423.17 EWC48794.1 - 9e-16 57.1 0.0 1.1e-15 56.8 0.0 1.1 1 0 0 1 1 1 1 LSM domain EMP24_GP25L PF01105.19 EWC48795.1 - 1.8e-49 167.9 0.2 2.1e-49 167.7 0.1 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD FAD_binding_1 PF00667.15 EWC48795.1 - 0.1 12.0 0.1 0.26 10.6 0.0 1.6 2 0 0 2 2 2 0 FAD binding domain Mob1_phocein PF03637.12 EWC48796.1 - 2.8e-56 189.9 2.8 1.3e-31 109.6 0.0 2.1 2 0 0 2 2 2 2 Mob1/phocein family Leo1 PF04004.8 EWC48797.1 - 4.2e-24 85.1 0.0 4.2e-24 85.1 0.0 2.9 2 1 1 3 3 3 1 Leo1-like protein SET PF00856.23 EWC48799.1 - 3.2e-06 27.5 0.1 7.9e-06 26.2 0.0 1.6 2 0 0 2 2 2 1 SET domain SAF PF08666.7 EWC48799.1 - 0.13 12.6 0.0 4 7.9 0.0 2.3 2 0 0 2 2 2 0 SAF domain DOCK-C2 PF14429.1 EWC48801.1 - 3.3e-21 75.7 0.0 6.5e-21 74.8 0.0 1.5 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins Ded_cyto PF06920.8 EWC48801.1 - 9.9e-07 28.2 0.0 2.5e-06 26.8 0.0 1.6 1 0 0 1 1 1 1 Dedicator of cytokinesis SH3_9 PF14604.1 EWC48801.1 - 0.13 11.8 0.2 1 9.0 0.0 2.4 2 0 0 2 2 2 0 Variant SH3 domain KfrA_N PF11740.3 EWC48805.1 - 0.0033 17.8 0.3 0.0069 16.8 0.2 1.5 1 0 0 1 1 1 1 Plasmid replication region DNA-binding N-term DUF2280 PF10045.4 EWC48805.1 - 0.051 13.5 0.0 0.93 9.4 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2280) Unstab_antitox PF09720.5 EWC48805.1 - 0.22 11.2 3.8 0.32 10.7 1.9 1.8 1 1 1 2 2 2 0 Putative addiction module component Frataxin_Cyay PF01491.11 EWC48806.1 - 1e-31 108.9 0.0 1.2e-31 108.6 0.0 1.1 1 0 0 1 1 1 1 Frataxin-like domain WD40 PF00400.27 EWC48807.1 - 4.5e-08 32.6 4.2 0.00027 20.7 0.0 3.7 4 1 0 4 4 4 2 WD domain, G-beta repeat Ctf8 PF09696.5 EWC48809.1 - 5.7e-32 110.0 0.0 6.9e-32 109.7 0.0 1.1 1 0 0 1 1 1 1 Ctf8 DUF4200 PF13863.1 EWC48810.1 - 3.3 7.6 9.7 0.63 10.0 4.2 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) PHP PF02811.14 EWC48811.1 - 2.5e-13 50.1 0.0 8.8e-13 48.4 0.0 1.9 1 1 0 1 1 1 1 PHP domain tRNA-synt_1 PF00133.17 EWC48812.1 - 8.1e-36 123.2 0.0 8.3e-27 93.4 0.0 3.5 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.6 EWC48812.1 - 1.4e-16 60.2 0.2 5.4e-10 38.4 0.0 2.9 4 0 0 4 4 4 2 tRNA synthetases class I (M) Anticodon_1 PF08264.8 EWC48812.1 - 2.8e-11 43.4 0.0 1e-10 41.5 0.0 2.0 1 1 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.14 EWC48812.1 - 2.1e-06 27.0 0.0 3.7e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain Methyltransf_23 PF13489.1 EWC48813.1 - 2.7e-23 82.4 0.0 4.3e-23 81.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EWC48813.1 - 2.8e-10 40.5 0.0 5.3e-10 39.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EWC48813.1 - 1e-09 38.1 0.0 9.3e-09 35.0 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EWC48813.1 - 6.2e-08 33.2 0.0 3e-07 31.0 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EWC48813.1 - 1.7e-06 28.3 0.0 4.5e-06 26.9 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EWC48813.1 - 1.2e-05 25.6 0.0 7.2e-05 23.2 0.0 2.3 2 1 0 2 2 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EWC48813.1 - 0.00054 19.1 0.0 0.0027 16.8 0.0 2.1 1 1 1 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_26 PF13659.1 EWC48813.1 - 0.0014 18.6 0.0 0.0036 17.3 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 EWC48813.1 - 0.0021 17.1 0.4 0.0072 15.3 0.0 1.9 2 0 0 2 2 2 1 Putative methyltransferase MTS PF05175.9 EWC48813.1 - 0.011 15.1 0.0 0.018 14.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain CMAS PF02353.15 EWC48813.1 - 0.019 14.0 0.0 0.03 13.4 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_2 PF00891.13 EWC48813.1 - 0.045 12.9 0.0 0.069 12.3 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase Methyltransf_16 PF10294.4 EWC48813.1 - 0.05 13.0 0.0 0.083 12.3 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase PrmA PF06325.8 EWC48813.1 - 0.1 11.6 0.0 0.14 11.2 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Lsm_C PF14894.1 EWC48813.1 - 0.11 12.0 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 Lsm C-terminal DUF2470 PF10615.4 EWC48814.1 - 2.9e-14 53.0 0.1 4.2e-14 52.5 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2470) F-box-like PF12937.2 EWC48815.1 - 3.3e-05 23.5 2.3 3.8e-05 23.3 0.6 1.9 2 0 0 2 2 2 1 F-box-like F-box PF00646.28 EWC48815.1 - 0.0041 16.7 0.1 0.013 15.1 0.1 1.9 1 0 0 1 1 1 1 F-box domain Melibiase PF02065.13 EWC48816.1 - 1.5e-28 99.5 0.1 1.4e-27 96.4 0.1 2.0 1 1 0 1 1 1 1 Melibiase CBM_1 PF00734.13 EWC48816.1 - 9.9e-09 34.7 9.9 9.9e-09 34.7 6.9 2.6 2 0 0 2 2 2 1 Fungal cellulose binding domain Glyco_hydro_10 PF00331.15 EWC48817.1 - 5e-101 337.9 0.1 5.8e-101 337.7 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 CBM_1 PF00734.13 EWC48817.1 - 9.5e-13 47.5 10.1 9.5e-13 47.5 7.0 2.3 2 0 0 2 2 2 1 Fungal cellulose binding domain Glyco_hydro_42 PF02449.10 EWC48817.1 - 0.023 13.7 0.1 0.59 9.1 0.1 2.1 1 1 1 2 2 2 0 Beta-galactosidase F-box-like PF12937.2 EWC48818.1 - 9.2e-08 31.7 2.4 0.00054 19.6 0.1 2.4 2 0 0 2 2 2 2 F-box-like F-box PF00646.28 EWC48818.1 - 3e-05 23.5 1.1 0.058 13.0 0.0 2.7 2 0 0 2 2 2 2 F-box domain F-box-like PF12937.2 EWC48819.1 - 2.4e-08 33.5 0.2 5.4e-08 32.4 0.2 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EWC48819.1 - 3.4e-05 23.3 0.0 6.8e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 F-box domain NYN PF01936.13 EWC48820.1 - 6.3e-06 26.5 0.0 3.5e-05 24.1 0.0 1.8 1 1 1 2 2 2 1 NYN domain DnaJ PF00226.26 EWC48821.1 - 4.3e-27 93.6 0.4 1.4e-26 91.9 0.3 2.0 1 0 0 1 1 1 1 DnaJ domain zf-C2H2_jaz PF12171.3 EWC48821.1 - 1.2e-10 41.2 2.6 1.2e-10 41.2 1.8 2.4 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 EWC48821.1 - 1.2e-08 34.8 2.6 1.2e-08 34.8 1.8 2.0 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.2 EWC48821.1 - 2.4e-08 33.9 10.2 0.00045 20.2 0.4 2.7 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.1 EWC48821.1 - 2e-05 24.5 3.4 0.06 13.7 0.2 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.21 EWC48821.1 - 6.3e-05 23.0 6.7 0.088 13.1 0.3 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_6 PF13912.1 EWC48821.1 - 0.028 14.3 5.1 1.6 8.7 0.5 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger Pox_A28 PF04584.9 EWC48821.1 - 0.079 12.8 1.2 0.19 11.5 0.3 2.0 2 0 0 2 2 2 0 Poxvirus A28 family Churchill PF06573.6 EWC48821.1 - 0.13 12.2 1.7 1.5 8.8 0.4 2.4 2 0 0 2 2 2 0 Churchill protein zf-H2C2_2 PF13465.1 EWC48821.1 - 1.7 9.0 4.8 0.57 10.5 0.1 2.5 3 0 0 3 3 3 0 Zinc-finger double domain F-box-like PF12937.2 EWC48822.1 - 0.001 18.7 1.2 0.0017 18.0 0.8 1.3 1 0 0 1 1 1 1 F-box-like Fasciclin PF02469.17 EWC48823.1 - 8.2e-44 148.6 0.0 3.2e-23 82.1 0.0 2.1 2 0 0 2 2 2 2 Fasciclin domain Sugar_tr PF00083.19 EWC48824.1 - 2e-108 362.9 18.8 2.3e-108 362.7 13.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EWC48824.1 - 1.4e-21 76.6 25.4 2.4e-21 75.8 17.6 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Fungal_trans PF04082.13 EWC48825.1 - 4.1e-11 42.2 0.7 4e-10 39.0 0.5 2.2 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EWC48825.1 - 4.5e-09 36.0 9.3 8.9e-09 35.1 6.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.11 EWC48826.1 - 4.2e-38 130.9 53.7 2.8e-37 128.2 37.6 2.1 2 1 0 2 2 2 1 Major Facilitator Superfamily TPIP1 PF15338.1 EWC48826.1 - 0.03 14.1 0.3 0.076 12.8 0.2 1.7 1 0 0 1 1 1 0 p53-regulated apoptosis-inducing protein 1 DUF4407 PF14362.1 EWC48826.1 - 0.94 8.3 8.6 6.2 5.6 0.1 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4407) Dioxygenase_C PF00775.16 EWC48827.1 - 4.1e-11 42.4 0.3 8.7e-11 41.4 0.2 1.6 1 0 0 1 1 1 1 Dioxygenase PA14_2 PF10528.4 EWC48828.1 - 3.5e-17 62.3 0.3 6.7e-17 61.4 0.2 1.4 1 0 0 1 1 1 1 GLEYA domain PA14 PF07691.7 EWC48828.1 - 0.00019 21.0 0.1 0.00027 20.6 0.0 1.4 1 0 0 1 1 1 1 PA14 domain Ank_2 PF12796.2 EWC48830.1 - 9.5e-42 141.2 0.3 7.2e-12 45.4 0.1 6.5 4 1 2 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.1 EWC48830.1 - 6.6e-31 106.1 1.7 3.7e-05 24.0 0.0 8.5 5 3 4 9 9 9 5 Ankyrin repeats (many copies) Ank PF00023.25 EWC48830.1 - 7.4e-29 98.1 3.9 4.4e-05 23.0 0.0 9.9 10 1 0 10 10 10 6 Ankyrin repeat Ank_3 PF13606.1 EWC48830.1 - 1.1e-24 83.9 1.0 0.0048 17.0 0.0 10.0 11 0 0 11 11 11 5 Ankyrin repeat Ank_5 PF13857.1 EWC48830.1 - 9.9e-24 82.8 4.4 8.6e-07 29.0 0.6 5.9 6 0 0 6 6 6 4 Ankyrin repeats (many copies) SPRY PF00622.23 EWC48830.1 - 2.2e-12 47.1 0.1 4.8e-12 46.0 0.1 1.6 1 0 0 1 1 1 1 SPRY domain NACHT PF05729.7 EWC48830.1 - 2e-07 30.8 0.1 1.8e-06 27.7 0.0 2.4 2 0 0 2 2 2 1 NACHT domain AAA_16 PF13191.1 EWC48830.1 - 9.6e-07 28.9 0.1 5.8e-06 26.4 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain Apolipoprotein PF01442.13 EWC48830.1 - 0.068 12.6 5.3 0.065 12.7 0.2 2.8 2 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain AAA_19 PF13245.1 EWC48830.1 - 0.2 11.4 0.0 1.3 8.7 0.0 2.3 2 0 0 2 2 2 0 Part of AAA domain F-box-like PF12937.2 EWC48832.1 - 0.13 12.0 0.0 0.19 11.4 0.0 1.4 1 1 0 1 1 1 0 F-box-like Sugar_tr PF00083.19 EWC48834.1 - 3.1e-124 415.0 25.2 3.5e-124 414.8 17.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EWC48834.1 - 1.1e-26 93.4 32.2 5.2e-16 58.3 10.4 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2422 PF10337.4 EWC48838.1 - 5.1e-81 272.7 6.3 1.3e-79 268.1 0.1 3.1 3 0 0 3 3 3 2 Protein of unknown function (DUF2422) DUF2421 PF10334.4 EWC48838.1 - 1.4e-38 132.7 0.0 2.1e-35 122.4 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF2421) FUSC_2 PF13515.1 EWC48838.1 - 1.7e-08 34.4 16.1 1.7e-08 34.4 11.1 3.5 2 2 0 2 2 2 1 Fusaric acid resistance protein-like ALMT PF11744.3 EWC48838.1 - 0.0028 16.3 9.6 0.015 14.0 6.3 2.3 2 1 0 2 2 2 1 Aluminium activated malate transporter MARVEL PF01284.18 EWC48841.1 - 1.4e-24 86.5 14.0 1.8e-24 86.2 9.7 1.0 1 0 0 1 1 1 1 Membrane-associating domain NDUFA12 PF05071.11 EWC48842.1 - 3.4e-08 33.8 0.1 6.3e-08 33.0 0.1 1.4 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 Mto2_bdg PF12808.2 EWC48842.1 - 0.082 13.0 5.0 0.087 12.9 1.8 2.3 2 0 0 2 2 2 0 Micro-tubular organiser Mto1 C-term Mto2-binding region Pkinase PF00069.20 EWC48843.1 - 4.7e-75 252.1 0.0 6.7e-75 251.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC48843.1 - 3.8e-38 131.0 0.0 5.7e-38 130.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EWC48843.1 - 7.6e-09 34.9 0.0 1e-07 31.2 0.0 2.0 2 0 0 2 2 2 1 Kinase-like UBA_2 PF08587.6 EWC48843.1 - 3.3e-06 27.1 0.0 7.4e-06 26.0 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin associated domain (UBA) YukC PF10140.4 EWC48843.1 - 0.0064 15.0 0.0 0.01 14.4 0.0 1.2 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukC RIO1 PF01163.17 EWC48843.1 - 0.0083 15.4 0.4 0.023 14.0 0.0 1.8 2 0 0 2 2 2 1 RIO1 family APH PF01636.18 EWC48843.1 - 0.89 9.2 5.2 0.59 9.8 0.1 2.8 3 0 0 3 3 3 0 Phosphotransferase enzyme family zf-CCHC PF00098.18 EWC48845.1 - 1.6e-28 97.1 70.3 9.1e-07 28.5 1.1 9.3 9 0 0 9 9 9 7 Zinc knuckle zf-CCHC_3 PF13917.1 EWC48845.1 - 5.8e-07 29.1 46.9 0.047 13.4 0.1 7.3 2 2 4 6 6 6 5 Zinc knuckle zf-CCHC_6 PF15288.1 EWC48845.1 - 1.2e-05 24.9 57.2 0.00011 21.7 0.1 7.8 8 0 0 8 8 8 6 Zinc knuckle zf-CCHC_4 PF14392.1 EWC48845.1 - 5.4e-05 22.7 47.5 0.23 11.1 0.7 7.8 8 0 0 8 8 8 7 Zinc knuckle zf-CCHC_2 PF13696.1 EWC48845.1 - 0.00012 21.5 33.3 0.003 16.9 0.3 6.8 3 2 4 7 7 7 3 Zinc knuckle DUF2294 PF10057.4 EWC48845.1 - 0.17 11.5 0.0 0.26 10.9 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2294) Drf_FH1 PF06346.7 EWC48846.1 - 0.78 9.2 8.5 0.68 9.4 4.6 1.7 2 0 0 2 2 2 0 Formin Homology Region 1 PLDc PF00614.17 EWC48847.1 - 1.3e-17 63.0 0.9 5.7e-09 35.4 0.2 2.6 2 0 0 2 2 2 2 Phospholipase D Active site motif PX PF00787.19 EWC48847.1 - 1.8e-11 43.8 0.0 5.3e-10 39.0 0.0 2.8 1 1 0 1 1 1 1 PX domain PLDc_2 PF13091.1 EWC48847.1 - 1.6e-10 40.8 0.0 6.2e-07 29.2 0.0 2.6 2 0 0 2 2 2 2 PLD-like domain PH PF00169.24 EWC48847.1 - 0.001 19.2 0.0 0.0024 18.0 0.0 1.6 1 0 0 1 1 1 1 PH domain Oxysterol_BP PF01237.13 EWC48848.1 - 6.2e-113 376.8 0.1 1.1e-112 376.1 0.1 1.4 1 0 0 1 1 1 1 Oxysterol-binding protein PH_8 PF15409.1 EWC48848.1 - 4e-32 110.1 0.0 8.2e-32 109.1 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain Alpha_GJ PF03229.8 EWC48849.1 - 0.011 16.0 1.5 0.029 14.6 0.0 2.3 2 0 0 2 2 2 0 Alphavirus glycoprotein J Podoplanin PF05808.6 EWC48849.1 - 0.02 14.4 0.0 0.038 13.5 0.0 1.4 1 0 0 1 1 1 0 Podoplanin IncA PF04156.9 EWC48849.1 - 0.095 12.2 0.0 0.15 11.6 0.0 1.2 1 0 0 1 1 1 0 IncA protein DUF1191 PF06697.7 EWC48849.1 - 0.1 11.4 0.0 0.15 10.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1191) Herpes_gE PF02480.11 EWC48849.1 - 0.14 10.4 0.0 0.22 9.7 0.0 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E Actin PF00022.14 EWC48850.1 - 1.3e-129 432.0 0.0 1.5e-129 431.8 0.0 1.0 1 0 0 1 1 1 1 Actin eIF3g PF12353.3 EWC48851.1 - 0.0021 17.9 9.8 0.067 13.1 2.2 3.0 2 1 1 3 3 3 2 Eukaryotic translation initiation factor 3 subunit G zf-CCHC PF00098.18 EWC48851.1 - 0.0068 16.2 2.7 0.024 14.5 0.5 2.4 2 0 0 2 2 2 1 Zinc knuckle DUF3602 PF12223.3 EWC48852.1 - 2.6e-15 56.5 5.6 1.8e-11 44.2 1.0 3.1 1 1 2 3 3 3 3 Protein of unknown function (DUF3602) Peptidase_S28 PF05577.7 EWC48853.1 - 2.1e-50 171.5 0.0 1.4e-49 168.8 0.0 2.1 1 1 0 1 1 1 1 Serine carboxypeptidase S28 Abhydrolase_6 PF12697.2 EWC48853.1 - 4.1e-05 23.5 1.6 0.00054 19.9 1.1 2.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Aldedh PF00171.17 EWC48854.1 - 7.3e-80 268.5 0.0 9e-80 268.2 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family ECR1_N PF14382.1 EWC48856.1 - 1.1e-11 43.8 0.0 2e-11 42.9 0.0 1.5 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region EXOSC1 PF10447.4 EWC48856.1 - 0.0011 18.9 0.0 0.011 15.6 0.0 2.5 2 1 0 2 2 2 1 Exosome component EXOSC1/CSL4 S1 PF00575.18 EWC48856.1 - 0.11 12.6 0.0 1.5 8.9 0.0 2.8 2 0 0 2 2 2 0 S1 RNA binding domain Amidohydro_4 PF13147.1 EWC48857.1 - 1.2e-10 41.9 3.2 1.9e-10 41.2 2.0 1.4 1 1 0 1 1 1 1 Amidohydrolase Amidohydro_2 PF04909.9 EWC48857.1 - 4.1e-07 29.8 0.6 2e-06 27.6 0.3 2.1 1 1 0 1 1 1 1 Amidohydrolase Amidohydro_1 PF01979.15 EWC48857.1 - 0.0003 20.5 0.0 0.00061 19.5 0.0 1.5 1 1 0 1 1 1 1 Amidohydrolase family CheY-binding PF09078.6 EWC48857.1 - 0.17 11.9 0.1 0.31 11.0 0.0 1.4 1 0 0 1 1 1 0 CheY binding eIF-5_eIF-2B PF01873.12 EWC48858.1 - 1.1e-41 141.4 0.0 2.1e-41 140.4 0.0 1.4 1 0 0 1 1 1 1 Domain found in IF2B/IF5 TF_Zn_Ribbon PF08271.7 EWC48858.1 - 0.28 10.5 1.9 0.59 9.4 1.3 1.5 1 0 0 1 1 1 0 TFIIB zinc-binding Elf1 PF05129.8 EWC48858.1 - 7.1 6.3 8.0 0.19 11.4 0.3 2.3 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like YycC PF14174.1 EWC48860.1 - 0.12 12.0 0.4 0.27 10.9 0.3 1.5 1 0 0 1 1 1 0 YycC-like protein Sec1 PF00995.18 EWC48861.1 - 1.5e-157 525.6 0.0 1.9e-157 525.3 0.0 1.0 1 0 0 1 1 1 1 Sec1 family adh_short PF00106.20 EWC48862.1 - 4.9e-26 91.6 0.1 7.1e-26 91.1 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EWC48862.1 - 5.4e-13 49.2 0.2 5.4e-13 49.2 0.1 1.5 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EWC48862.1 - 4.5e-08 32.9 0.4 1.2e-07 31.6 0.2 1.6 1 1 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 EWC48862.1 - 2.4e-05 24.3 0.1 0.00024 21.1 0.0 2.2 1 1 0 1 1 1 1 NADH(P)-binding Cyclase PF04199.8 EWC48862.1 - 0.034 13.8 0.0 0.052 13.2 0.0 1.2 1 0 0 1 1 1 0 Putative cyclase Epimerase PF01370.16 EWC48862.1 - 0.038 13.4 0.1 0.058 12.8 0.0 1.4 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family UPF0146 PF03686.8 EWC48862.1 - 0.074 12.8 0.0 1.4 8.7 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0146) RmlD_sub_bind PF04321.12 EWC48862.1 - 0.082 11.7 0.0 0.13 11.1 0.0 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain WD40 PF00400.27 EWC48866.1 - 2.3e-61 201.6 27.0 7e-12 44.7 0.4 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.3 EWC48866.1 - 0.0007 17.8 8.5 0.63 8.1 0.1 4.2 1 1 3 4 4 4 3 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.11 EWC48866.1 - 0.044 12.0 0.1 5.6 5.1 0.0 2.3 2 1 0 2 2 2 0 Cytochrome D1 heme domain FHA PF00498.21 EWC48867.1 - 6.4e-13 48.6 0.0 1.3e-12 47.6 0.0 1.6 1 0 0 1 1 1 1 FHA domain Plus-3 PF03126.13 EWC48868.1 - 3.4e-20 72.0 0.0 1e-19 70.5 0.0 1.9 1 0 0 1 1 1 1 Plus-3 domain DUF501 PF04417.7 EWC48868.1 - 1.1 9.0 7.8 0.92 9.3 1.5 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF501) Pkinase PF00069.20 EWC48869.1 - 3.1e-70 236.2 0.0 3.9e-70 235.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EWC48869.1 - 5.9e-31 107.4 0.0 1e-30 106.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 EWC48869.1 - 0.016 14.9 0.5 0.065 12.9 0.1 2.1 2 1 0 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.9 EWC48869.1 - 0.076 12.0 0.0 0.21 10.6 0.0 1.7 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PLDc_2 PF13091.1 EWC48870.1 - 1.7e-17 63.3 0.0 1e-10 41.4 0.0 2.6 2 1 0 2 2 2 2 PLD-like domain Regulator_TrmB PF11495.3 EWC48870.1 - 0.023 13.7 0.0 0.051 12.5 0.0 1.5 1 0 0 1 1 1 0 Archaeal transcriptional regulator TrmB PXA PF02194.10 EWC48870.1 - 0.21 11.1 0.0 0.41 10.1 0.0 1.4 1 0 0 1 1 1 0 PXA domain PLDc PF00614.17 EWC48870.1 - 0.21 11.4 3.2 3.8 7.4 0.0 3.2 4 0 0 4 4 4 0 Phospholipase D Active site motif Sas10 PF09368.5 EWC48871.1 - 3.4e-29 100.8 4.1 3.4e-29 100.8 2.8 2.4 3 0 0 3 3 3 1 Sas10 C-terminal domain Sas10_Utp3 PF04000.10 EWC48871.1 - 4.5e-06 26.7 0.1 5.5e-05 23.2 0.0 2.8 4 0 0 4 4 4 1 Sas10/Utp3/C1D family DUF3661 PF12400.3 EWC48872.1 - 0.1 12.6 0.0 0.14 12.2 0.0 1.3 1 0 0 1 1 1 0 Vaculolar membrane protein MFS_1 PF07690.11 EWC48873.1 - 7.9e-34 116.9 24.6 7.9e-34 116.9 17.1 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.11 EWC48873.1 - 0.0013 18.2 4.4 0.0034 16.8 3.0 1.7 1 0 0 1 1 1 1 Ion channel regulatory protein UNC-93 F-box-like PF12937.2 EWC48876.1 - 0.0086 15.7 0.3 0.02 14.6 0.2 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EWC48876.1 - 0.034 13.8 0.1 0.058 13.0 0.1 1.4 1 0 0 1 1 1 0 F-box domain RasGAP PF00616.14 EWC48877.1 - 6.2e-41 140.2 0.0 1e-40 139.4 0.0 1.3 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase Lactamase_B_2 PF12706.2 EWC48878.1 - 0.00024 20.6 0.0 0.00043 19.8 0.0 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.22 EWC48878.1 - 0.0038 16.9 0.0 0.0076 15.9 0.0 1.6 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily TPR_11 PF13414.1 EWC48880.1 - 1.7e-51 171.7 20.5 1.4e-13 50.2 0.8 6.6 4 2 1 6 6 6 6 TPR repeat TPR_1 PF00515.23 EWC48880.1 - 3.4e-41 137.1 17.6 0.00034 20.0 0.0 11.5 10 1 1 11 11 11 10 Tetratricopeptide repeat TPR_2 PF07719.12 EWC48880.1 - 4.4e-41 135.5 15.7 0.00059 19.5 0.0 11.7 10 1 1 11 11 11 10 Tetratricopeptide repeat TPR_16 PF13432.1 EWC48880.1 - 3.1e-24 85.0 6.5 1.8e-06 28.4 0.1 6.7 5 2 1 7 7 6 4 Tetratricopeptide repeat TPR_17 PF13431.1 EWC48880.1 - 1.2e-23 81.2 4.0 0.02 15.0 0.0 9.3 9 0 0 9 9 8 7 Tetratricopeptide repeat TPR_12 PF13424.1 EWC48880.1 - 9.8e-19 67.0 24.5 2.4e-07 30.5 0.8 7.7 3 3 5 8 8 8 5 Tetratricopeptide repeat TPR_14 PF13428.1 EWC48880.1 - 1.2e-14 53.4 9.3 0.022 15.3 0.1 8.9 4 3 6 10 10 10 3 Tetratricopeptide repeat TPR_8 PF13181.1 EWC48880.1 - 2.6e-14 51.8 22.0 0.025 14.3 0.0 9.7 9 1 1 10 10 9 4 Tetratricopeptide repeat TPR_9 PF13371.1 EWC48880.1 - 9.1e-14 51.0 5.6 0.0029 17.4 0.0 6.0 4 2 3 7 7 7 4 Tetratricopeptide repeat TPR_7 PF13176.1 EWC48880.1 - 1.5e-12 46.3 19.7 0.016 14.9 0.1 9.3 8 1 1 9 9 9 3 Tetratricopeptide repeat TPR_19 PF14559.1 EWC48880.1 - 2.5e-12 46.9 18.0 8.2e-06 26.0 0.7 7.2 4 2 5 9 9 9 3 Tetratricopeptide repeat TPR_15 PF13429.1 EWC48880.1 - 6.7e-11 41.7 1.3 0.0018 17.3 0.2 4.6 2 2 2 4 4 4 3 Tetratricopeptide repeat Apc3 PF12895.2 EWC48880.1 - 3.4e-09 36.7 16.5 0.0007 19.6 0.4 5.5 3 1 3 6 6 6 5 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.1 EWC48880.1 - 0.00038 20.7 20.8 2.7 8.6 0.0 8.5 10 0 0 10 10 9 2 Tetratricopeptide repeat NTP_transferase PF00483.18 EWC48880.1 - 0.0059 15.9 0.1 0.015 14.6 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyl transferase TPR_3 PF07720.7 EWC48880.1 - 0.052 13.3 9.0 10 6.0 0.0 5.2 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_10 PF13374.1 EWC48880.1 - 0.13 12.2 0.2 0.13 12.2 0.2 4.7 5 0 0 5 5 4 0 Tetratricopeptide repeat DUF3366 PF11846.3 EWC48880.1 - 0.2 11.5 3.4 0.54 10.0 0.2 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF3366) TPR_4 PF07721.9 EWC48880.1 - 1.3 9.6 4.6 24 5.7 0.0 5.1 7 0 0 7 7 5 0 Tetratricopeptide repeat SHNi-TPR PF10516.4 EWC48880.1 - 5.6 6.2 18.5 6.8 6.0 0.1 6.0 7 0 0 7 7 7 0 SHNi-TPR RF-1 PF00472.15 EWC48881.1 - 1.3e-34 118.3 2.4 1.3e-34 118.3 1.6 1.7 2 0 0 2 2 2 1 RF-1 domain PCRF PF03462.13 EWC48881.1 - 1.9e-23 82.3 0.0 7.7e-23 80.4 0.0 2.1 2 0 0 2 2 2 1 PCRF domain CorA PF01544.13 EWC48881.1 - 0.19 10.7 0.3 0.32 9.9 0.2 1.3 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein adh_short PF00106.20 EWC48882.1 - 1.5e-20 73.8 0.0 2.5e-20 73.0 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EWC48882.1 - 1.8e-08 34.4 0.0 3.2e-08 33.6 0.0 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EWC48882.1 - 6.1e-08 32.5 0.0 1.5e-07 31.2 0.0 1.6 1 1 0 1 1 1 1 KR domain THF_DHG_CYH_C PF02882.14 EWC48882.1 - 6e-07 28.6 0.4 1.2e-06 27.7 0.2 1.4 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain NAD_binding_10 PF13460.1 EWC48882.1 - 0.0006 19.8 1.3 0.0052 16.8 0.8 2.4 2 1 0 2 2 2 1 NADH(P)-binding Eno-Rase_NADH_b PF12242.3 EWC48882.1 - 0.00067 19.3 1.9 0.0019 17.9 0.7 2.2 2 1 1 3 3 3 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase 3HCDH_N PF02737.13 EWC48882.1 - 0.0025 17.4 0.3 0.0044 16.6 0.2 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Meleagrin PF08189.6 EWC48882.1 - 0.015 14.7 1.2 0.19 11.2 0.8 2.3 1 1 0 1 1 1 0 Meleagrin/Cygnin family Shikimate_DH PF01488.15 EWC48882.1 - 0.062 13.4 0.3 0.16 12.0 0.1 1.8 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase APH PF01636.18 EWC48883.1 - 3.7e-13 49.7 0.1 7.4e-13 48.7 0.1 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 EWC48883.1 - 0.00067 19.2 0.0 0.00093 18.8 0.0 1.1 1 0 0 1 1 1 1 Choline/ethanolamine kinase L1R_F9L PF02442.12 EWC48886.1 - 0.0034 16.9 1.1 0.0051 16.3 0.8 1.3 1 0 0 1 1 1 1 Lipid membrane protein of large eukaryotic DNA viruses TrbL PF04610.9 EWC48886.1 - 0.063 12.9 1.9 0.097 12.3 1.3 1.3 1 0 0 1 1 1 0 TrbL/VirB6 plasmid conjugal transfer protein DUF605 PF04652.11 EWC48886.1 - 0.14 11.4 18.9 0.2 11.0 13.1 1.2 1 0 0 1 1 1 0 Vta1 like TFIIA PF03153.8 EWC48886.1 - 0.23 11.3 8.7 0.26 11.1 6.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Macoilin PF09726.4 EWC48886.1 - 1.6 6.9 11.8 2.1 6.5 8.2 1.1 1 0 0 1 1 1 0 Transmembrane protein RAP1 PF07218.6 EWC48886.1 - 3.3 5.6 14.8 4.5 5.2 10.3 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Ndc1_Nup PF09531.5 EWC48886.1 - 5.1 5.4 7.1 5.4 5.3 4.3 1.5 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup Dynamin_N PF00350.18 EWC48887.1 - 4.3e-27 94.9 0.3 1.2e-26 93.5 0.1 1.9 2 0 0 2 2 2 1 Dynamin family Dynamin_M PF01031.15 EWC48887.1 - 2.2e-14 52.9 0.1 3e-12 45.9 0.0 2.6 2 1 1 3 3 3 2 Dynamin central region MMR_HSR1 PF01926.18 EWC48887.1 - 9.9e-05 22.2 0.1 0.0031 17.4 0.0 3.2 3 1 0 3 3 3 1 50S ribosome-binding GTPase Miro PF08477.8 EWC48887.1 - 0.015 15.8 0.1 0.065 13.7 0.0 2.1 2 0 0 2 2 2 0 Miro-like protein VASP_tetra PF08776.6 EWC48887.1 - 0.048 12.9 0.2 0.13 11.5 0.1 1.7 1 0 0 1 1 1 0 VASP tetramerisation domain Gln-synt_C PF00120.19 EWC48888.1 - 6.4e-62 209.0 0.0 7.9e-62 208.7 0.0 1.1 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.14 EWC48888.1 - 3.1e-19 68.3 0.0 6.3e-19 67.3 0.0 1.5 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain SLS PF14611.1 EWC48888.1 - 0.063 12.7 0.1 0.13 11.6 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial inner-membrane-bound regulator G_glu_transpept PF01019.16 EWC48889.1 - 2.1e-144 481.8 0.1 2.4e-144 481.6 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase DUF159 PF02586.9 EWC48890.1 - 6.1e-52 176.1 0.0 9.6e-52 175.5 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, COG2135 TPR_12 PF13424.1 EWC48891.1 - 1.1e-12 47.6 3.1 0.0051 16.7 0.0 4.7 3 2 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.1 EWC48891.1 - 1.7e-09 37.1 8.1 0.0081 15.7 0.1 3.9 4 0 0 4 4 4 3 TPR repeat TPR_2 PF07719.12 EWC48891.1 - 1.5e-08 33.8 12.0 0.033 14.1 0.0 5.7 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.1 EWC48891.1 - 3.1e-07 29.6 7.7 0.045 13.5 0.0 5.4 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.23 EWC48891.1 - 4.1e-05 22.9 10.9 0.65 9.6 0.0 5.0 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.1 EWC48891.1 - 5.5e-05 22.6 3.0 2.4 8.1 0.0 5.0 4 0 0 4 4 4 2 Tetratricopeptide repeat HHH_8 PF14716.1 EWC48891.1 - 0.00012 22.2 1.5 0.95 9.6 0.1 3.4 3 0 0 3 3 3 2 Helix-hairpin-helix domain TPR_16 PF13432.1 EWC48891.1 - 0.00013 22.5 1.2 3.1 8.5 0.1 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat SNAP PF14938.1 EWC48891.1 - 0.0012 18.1 3.5 0.68 9.0 0.1 2.8 3 0 0 3 3 3 2 Soluble NSF attachment protein, SNAP TPR_6 PF13174.1 EWC48891.1 - 0.0021 18.4 9.5 1.2 9.7 0.1 4.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_10 PF13374.1 EWC48891.1 - 0.2 11.6 2.6 21 5.2 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF1896 PF08989.5 EWC48892.1 - 0.062 13.1 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1896) Laminin_I PF06008.9 EWC48892.1 - 0.21 10.8 4.7 1.3 8.3 0.0 2.2 2 0 0 2 2 2 0 Laminin Domain I zf-U1 PF06220.7 EWC48893.1 - 3.8e-06 26.3 0.3 5.6e-06 25.8 0.2 1.2 1 0 0 1 1 1 1 U1 zinc finger PALP PF00291.20 EWC48894.1 - 1.3e-41 142.7 0.3 1.4e-34 119.7 0.1 2.2 2 0 0 2 2 2 2 Pyridoxal-phosphate dependent enzyme 2OG-FeII_Oxy_2 PF13532.1 EWC48895.1 - 2e-21 76.7 0.0 7.1e-13 48.8 0.0 2.4 2 0 0 2 2 2 2 2OG-Fe(II) oxygenase superfamily Isochorismatase PF00857.15 EWC48895.1 - 3.5e-18 66.1 0.1 5.7e-13 49.1 0.0 3.0 3 0 0 3 3 3 2 Isochorismatase family GST_C_3 PF14497.1 EWC48895.1 - 0.015 15.7 0.0 0.1 13.1 0.0 2.3 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain ZF-HD_dimer PF04770.7 EWC48896.1 - 0.0022 17.9 3.7 0.0063 16.5 2.6 1.7 1 0 0 1 1 1 1 ZF-HD protein dimerisation region DUF2752 PF10825.3 EWC48896.1 - 0.066 13.2 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2752) DUF3431 PF11913.3 EWC48898.1 - 4.7e-69 232.2 0.0 5.4e-69 232.0 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3431) Asp PF00026.18 EWC48899.1 - 2.8e-06 26.8 0.0 4.6e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic aspartyl protease CAMSAP_CH PF11971.3 EWC48900.1 - 0.013 15.1 0.1 0.027 14.1 0.1 1.5 1 0 0 1 1 1 0 CAMSAP CH domain LRR_4 PF12799.2 EWC48900.1 - 0.018 14.6 2.2 0.86 9.3 0.0 3.3 2 1 0 2 2 2 0 Leucine Rich repeats (2 copies) DUF2427 PF10348.4 EWC48905.1 - 4.5e-05 22.9 5.3 0.00021 20.8 2.8 2.2 1 1 1 2 2 2 2 Domain of unknown function (DUF2427) Cytochrom_B561 PF03188.11 EWC48905.1 - 0.00068 19.4 10.6 0.00068 19.4 7.4 2.1 2 1 1 3 3 3 1 Eukaryotic cytochrome b561 SdpI PF13630.1 EWC48905.1 - 0.0017 17.9 9.9 0.017 14.7 3.1 3.1 2 1 1 3 3 3 1 SdpI/YhfL protein family DUF2306 PF10067.4 EWC48905.1 - 0.011 15.8 2.5 0.011 15.8 1.8 3.1 1 1 1 3 3 3 0 Predicted membrane protein (DUF2306) TMEM125 PF15109.1 EWC48905.1 - 0.022 14.8 1.2 0.42 10.7 0.6 2.3 2 0 0 2 2 2 0 TMEM125 protein family Protocadherin PF08374.6 EWC48905.1 - 0.036 13.6 0.1 0.055 13.1 0.1 1.3 1 0 0 1 1 1 0 Protocadherin 5_nucleotid PF05761.9 EWC48906.1 - 0.011 14.2 0.0 0.015 13.8 0.0 1.1 1 0 0 1 1 1 0 5' nucleotidase family SNF2_N PF00176.18 EWC48907.1 - 4.1e-80 268.7 0.3 7.3e-80 267.9 0.2 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.5 EWC48907.1 - 1.8e-41 140.6 2.1 6.1e-41 138.8 1.5 2.0 1 0 0 1 1 1 1 SLIDE HAND PF09110.6 EWC48907.1 - 2.6e-31 108.3 3.6 2.6e-31 108.3 2.5 3.5 4 0 0 4 4 4 1 HAND Helicase_C PF00271.26 EWC48907.1 - 3.2e-14 52.5 0.0 7.6e-14 51.3 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HDA2-3 PF11496.3 EWC48907.1 - 3.9e-08 32.4 0.0 1.3e-07 30.7 0.0 1.9 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.10 EWC48907.1 - 1.1e-07 31.8 2.8 2.4e-07 30.7 0.0 3.1 3 1 0 3 3 3 1 Type III restriction enzyme, res subunit DEAD PF00270.24 EWC48907.1 - 0.0011 18.4 0.0 0.0043 16.5 0.0 2.0 1 0 0 1 1 1 1 DEAD/DEAH box helicase DEAD_2 PF06733.10 EWC48907.1 - 0.012 15.0 0.0 0.036 13.4 0.0 1.8 1 0 0 1 1 1 0 DEAD_2 AAA_14 PF13173.1 EWC48907.1 - 0.017 15.0 0.1 0.12 12.2 0.0 2.6 2 0 0 2 2 2 0 AAA domain DUF4588 PF15251.1 EWC48908.1 - 0.065 13.1 14.6 0.033 14.1 6.8 2.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4588) DUF3712 PF12505.3 EWC48910.1 - 3.3e-23 82.0 2.7 3.3e-23 82.0 1.9 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF3712) DUF1565 PF07602.6 EWC48910.1 - 0.0059 15.7 2.4 0.033 13.3 0.1 2.2 1 1 1 2 2 2 1 Protein of unknown function (DUF1565) WBP-1 PF11669.3 EWC48910.1 - 0.18 11.8 0.2 0.3 11.1 0.2 1.4 1 0 0 1 1 1 0 WW domain-binding protein 1 zf-C2H2 PF00096.21 EWC48911.1 - 8.8e-05 22.6 12.2 0.0028 17.8 1.3 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type HALZ PF02183.13 EWC48911.1 - 0.0017 17.9 1.1 0.0034 17.0 0.8 1.4 1 0 0 1 1 1 1 Homeobox associated leucine zipper zf-C2H2_4 PF13894.1 EWC48911.1 - 0.0045 17.2 10.3 0.082 13.2 0.3 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger TLE_N PF03920.10 EWC48911.1 - 0.0048 16.7 0.0 0.011 15.5 0.0 1.5 1 0 0 1 1 1 1 Groucho/TLE N-terminal Q-rich domain zf-C2H2_6 PF13912.1 EWC48911.1 - 0.96 9.4 5.4 4.8 7.2 0.6 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger RNB PF00773.14 EWC48912.1 - 4.8e-82 275.8 0.1 1.1e-81 274.6 0.0 1.6 1 0 0 1 1 1 1 RNB domain Ferritin_2 PF13668.1 EWC48913.1 - 1.7e-39 134.9 0.5 2.3e-39 134.4 0.3 1.2 1 0 0 1 1 1 1 Ferritin-like domain IU_nuc_hydro PF01156.14 EWC48914.1 - 8.8e-55 186.1 0.0 5.9e-46 157.1 0.0 2.0 2 0 0 2 2 2 2 Inosine-uridine preferring nucleoside hydrolase Pyocin_S PF06958.7 EWC48915.1 - 0.00016 22.0 3.1 0.00028 21.2 2.1 1.5 1 0 0 1 1 1 1 S-type Pyocin zf-C2H2 PF00096.21 EWC48915.1 - 0.25 11.7 4.7 0.57 10.6 0.4 3.0 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EWC48915.1 - 0.26 11.6 3.5 0.92 9.9 0.4 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger Evr1_Alr PF04777.8 EWC48916.1 - 0.15 11.9 0.0 0.32 10.9 0.0 1.5 1 0 0 1 1 1 0 Erv1 / Alr family AAA_12 PF13087.1 EWC48917.1 - 2.1e-37 128.4 0.0 4.6e-37 127.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 EWC48917.1 - 9.4e-25 87.5 0.0 1.8e-24 86.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 EWC48917.1 - 8.7e-07 28.6 0.0 2.4e-06 27.1 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain DUF2075 PF09848.4 EWC48917.1 - 2.7e-06 26.5 0.0 0.00053 19.0 0.0 2.5 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.1 EWC48917.1 - 4e-05 23.2 0.0 0.004 16.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 EWC48917.1 - 0.0009 19.2 2.3 0.0028 17.6 0.0 2.9 2 1 0 2 2 2 1 AAA ATPase domain AAA_17 PF13207.1 EWC48917.1 - 0.029 15.1 0.0 0.11 13.3 0.0 2.1 1 0 0 1 1 1 0 AAA domain UvrD_C_2 PF13538.1 EWC48917.1 - 0.058 13.5 0.0 0.17 12.0 0.0 1.9 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain zf-C2H2_4 PF13894.1 EWC48918.1 - 7e-05 22.8 6.6 0.027 14.8 0.7 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.21 EWC48918.1 - 7.8e-05 22.7 12.3 0.05 13.9 1.1 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.3 EWC48918.1 - 0.00013 22.0 5.5 0.00034 20.6 3.8 1.8 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 EWC48918.1 - 0.00015 21.8 7.3 0.00043 20.3 3.2 2.5 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-U1 PF06220.7 EWC48918.1 - 0.2 11.2 3.4 0.22 11.0 1.3 1.9 2 0 0 2 2 2 0 U1 zinc finger zf-C2H2_2 PF12756.2 EWC48918.1 - 1.1 9.4 9.5 0.51 10.4 3.0 2.2 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-H2C2_2 PF13465.1 EWC48918.1 - 7.4 7.0 12.5 0.46 10.8 0.9 3.0 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2H2 PF00096.21 EWC48919.1 - 3.5e-05 23.8 6.8 0.014 15.7 0.5 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EWC48919.1 - 3.5e-05 23.8 5.0 0.13 12.6 0.2 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.2 EWC48919.1 - 4.8e-05 23.4 1.3 0.01 15.9 0.2 2.6 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 EWC48919.1 - 0.00022 21.2 5.7 0.11 12.6 0.3 2.4 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding Yippee-Mis18 PF03226.9 EWC48919.1 - 0.026 14.5 0.1 0.038 14.0 0.1 1.2 1 0 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly HNH PF01844.18 EWC48919.1 - 0.032 14.1 0.1 0.032 14.1 0.1 2.6 3 0 0 3 3 3 0 HNH endonuclease zf-C2H2_2 PF12756.2 EWC48919.1 - 0.071 13.2 3.5 0.24 11.5 0.4 2.1 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) MutS_V PF00488.16 EWC48920.1 - 2.3e-52 177.7 0.1 6.2e-52 176.3 0.0 1.8 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.13 EWC48920.1 - 3.1e-29 102.2 0.0 6.4e-29 101.1 0.0 1.5 1 0 0 1 1 1 1 MutS domain III AAA_22 PF13401.1 EWC48920.1 - 0.0074 16.4 0.1 0.032 14.3 0.0 2.0 2 0 0 2 2 2 1 AAA domain Ino80_Iec3 PF14612.1 EWC48921.1 - 2.9e-36 125.6 2.9 2.8e-25 89.7 0.6 2.2 2 0 0 2 2 2 2 IEC3 subunit of the Ino80 complex, chromatin re-modelling SUV3_C PF12513.3 EWC48921.1 - 0.039 13.3 0.5 11 5.5 0.2 2.5 2 0 0 2 2 2 0 Mitochondrial degradasome RNA helicase subunit C terminal RRM_6 PF14259.1 EWC48922.1 - 1.1e-22 79.8 0.1 1.6e-11 44.0 0.0 2.9 2 1 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 EWC48922.1 - 2.1e-19 68.8 2.8 3.2e-11 42.6 0.1 3.7 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EWC48922.1 - 1.6e-08 34.2 0.7 0.0011 18.8 0.0 3.0 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CDC45 PF02724.9 EWC48922.1 - 0.33 8.9 6.0 0.49 8.3 4.1 1.2 1 0 0 1 1 1 0 CDC45-like protein DNA_pol_phi PF04931.8 EWC48922.1 - 0.5 8.0 10.5 0.75 7.4 7.3 1.1 1 0 0 1 1 1 0 DNA polymerase phi RR_TM4-6 PF06459.7 EWC48922.1 - 0.57 10.0 5.5 0.85 9.4 1.8 2.2 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 CENP-B_dimeris PF09026.5 EWC48922.1 - 4 7.7 10.1 8.6 6.6 7.0 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain PA14_2 PF10528.4 EWC48926.1 - 4.2e-14 52.4 0.2 5.9e-14 51.9 0.2 1.2 1 0 0 1 1 1 1 GLEYA domain LRR_6 PF13516.1 EWC48927.1 - 0.08 13.0 0.0 19 5.6 0.0 3.2 2 0 0 2 2 2 0 Leucine Rich repeat Ribosomal_L5 PF00281.14 EWC48927.1 - 0.18 11.6 0.0 0.39 10.5 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein L5 MSP1_C PF07462.6 EWC48927.1 - 4.2 5.6 4.1 5.8 5.1 2.9 1.1 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus Methyltransf_18 PF12847.2 EWC48928.1 - 5.9e-07 30.0 0.0 9.6e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EWC48928.1 - 7.1e-05 23.2 0.0 0.00012 22.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EWC48928.1 - 7.3e-05 22.3 0.0 0.00011 21.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EWC48928.1 - 0.00034 19.7 0.0 0.00063 18.9 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_32 PF13679.1 EWC48928.1 - 0.0052 16.4 0.0 0.0077 15.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EWC48928.1 - 0.0062 17.0 0.0 0.011 16.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EWC48928.1 - 0.049 14.0 0.0 0.077 13.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain LCM PF04072.9 EWC48928.1 - 0.083 12.4 0.0 0.13 11.8 0.0 1.2 1 0 0 1 1 1 0 Leucine carboxyl methyltransferase DUF3433 PF11915.3 EWC48929.1 - 1e-40 137.7 13.0 7.2e-23 80.5 1.6 2.9 2 0 0 2 2 2 2 Protein of unknown function (DUF3433) DUF4381 PF14316.1 EWC48929.1 - 4.1 7.4 8.3 35 4.4 3.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) MMgT PF10270.4 EWC48930.1 - 2.9e-22 79.1 0.0 3.9e-22 78.6 0.0 1.2 1 0 0 1 1 1 1 Membrane magnesium transporter EF1_GNE PF00736.14 EWC48931.1 - 7.2e-32 108.9 1.5 1.2e-31 108.1 1.0 1.4 1 0 0 1 1 1 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.4 EWC48931.1 - 3e-14 52.8 8.4 3e-14 52.8 5.8 2.4 2 0 0 2 2 2 1 Eukaryotic elongation factor 1 beta central acidic region GST_C_3 PF14497.1 EWC48931.1 - 0.042 14.3 0.0 0.13 12.7 0.0 1.8 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain eIF3_subunit PF08597.5 EWC48931.1 - 0.043 13.3 7.1 0.073 12.6 4.9 1.3 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit CPDase PF07823.6 EWC48932.1 - 1.5e-20 73.5 0.0 1.9e-20 73.1 0.0 1.2 1 0 0 1 1 1 1 Cyclic phosphodiesterase-like protein 2_5_RNA_ligase2 PF13563.1 EWC48932.1 - 1.3e-06 28.2 0.0 2.3e-06 27.3 0.0 1.4 1 1 0 1 1 1 1 2'-5' RNA ligase superfamily F-box-like PF12937.2 EWC48935.1 - 0.006 16.2 0.2 0.023 14.3 0.1 2.0 1 1 0 1 1 1 1 F-box-like F-box PF00646.28 EWC48937.1 - 1.5e-08 34.0 1.1 3.1e-08 33.0 0.8 1.5 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 EWC48937.1 - 1.3e-06 28.0 1.4 3.4e-06 26.6 1.0 1.7 1 0 0 1 1 1 1 F-box-like F-box-like PF12937.2 EWC48938.1 - 1.8e-05 24.3 0.3 3.2e-05 23.5 0.2 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EWC48938.1 - 0.0067 16.0 0.1 0.015 14.9 0.0 1.5 1 0 0 1 1 1 1 F-box domain F-box PF00646.28 EWC48940.1 - 0.00021 20.8 0.1 0.00043 19.8 0.0 1.5 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 EWC48940.1 - 0.0038 16.9 0.9 0.0066 16.1 0.6 1.3 1 0 0 1 1 1 1 F-box-like CFEM PF05730.6 EWC48941.1 - 2.1e-10 40.2 5.6 3.5e-10 39.5 3.9 1.4 1 0 0 1 1 1 1 CFEM domain TPR_11 PF13414.1 EWC48944.1 - 8.3e-21 73.4 0.4 5.6e-17 61.1 0.3 4.2 4 0 0 4 4 4 2 TPR repeat TPR_1 PF00515.23 EWC48944.1 - 1.3e-15 56.1 1.6 0.00033 20.1 0.0 5.5 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.12 EWC48944.1 - 2.9e-13 48.6 5.3 0.0025 17.5 0.2 5.9 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.1 EWC48944.1 - 9.4e-08 31.3 1.7 0.088 12.6 0.1 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.1 EWC48944.1 - 4.6e-07 29.5 0.2 0.0022 18.0 0.2 3.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.1 EWC48944.1 - 5.3e-06 26.9 10.9 0.00019 22.0 1.6 4.5 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.1 EWC48944.1 - 1.9e-05 24.5 3.0 0.00051 19.9 1.0 3.2 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.1 EWC48944.1 - 8.1e-05 22.4 6.7 0.00036 20.3 0.7 3.2 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.1 EWC48944.1 - 0.00034 20.8 1.0 0.00034 20.8 0.7 2.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.1 EWC48944.1 - 0.18 12.5 10.5 5.9 7.8 0.1 4.8 3 1 2 5 5 5 0 Tetratricopeptide repeat ADH_N PF08240.7 EWC48945.1 - 1.8e-07 30.8 0.2 1.8e-06 27.6 0.1 2.1 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 EWC48945.1 - 3.4e-05 23.4 0.0 5.5e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Aldo_ket_red PF00248.16 EWC48946.1 - 1.9e-52 177.8 0.0 2.3e-52 177.6 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Cellulase PF00150.13 EWC48947.1 - 8.8e-17 61.2 0.1 8e-13 48.2 0.0 2.7 2 1 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_35 PF01301.14 EWC48947.1 - 0.091 12.0 0.1 0.15 11.3 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolases family 35 DUF1115 PF06544.7 EWC48948.1 - 5.3e-17 61.6 0.0 6.4e-17 61.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1115) Acylphosphatase PF00708.13 EWC48948.1 - 0.00099 19.1 0.0 0.0019 18.2 0.0 1.4 1 0 0 1 1 1 1 Acylphosphatase Lactamase_B_3 PF13483.1 EWC48949.1 - 0.00045 19.9 0.0 0.00084 19.0 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Ribosomal_L6e PF01159.14 EWC48953.1 - 1.9e-35 121.3 0.0 2.7e-35 120.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L6e Baculo_E56 PF04639.7 EWC48953.1 - 0.079 11.6 0.0 0.11 11.1 0.0 1.2 1 0 0 1 1 1 0 Baculoviral E56 protein, specific to ODV envelope Med25 PF11232.3 EWC48953.1 - 0.082 12.5 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 Mediator complex subunit 25 PTOV activation and synapsin 2 Rad10 PF03834.9 EWC48954.1 - 1.2e-29 101.7 0.0 2.8e-29 100.5 0.0 1.6 2 0 0 2 2 2 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) HHH_5 PF14520.1 EWC48954.1 - 8.4e-08 32.2 0.0 1.9e-07 31.1 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix domain HHH PF00633.18 EWC48954.1 - 5.4e-05 22.6 0.0 0.00012 21.5 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_2 PF12826.2 EWC48954.1 - 0.083 12.7 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 Helix-hairpin-helix motif Asp PF00026.18 EWC48955.1 - 5.7e-68 229.5 0.5 7.8e-68 229.0 0.3 1.2 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 EWC48955.1 - 2.2e-12 47.2 0.1 4.3e-11 43.0 0.0 2.7 3 0 0 3 3 3 1 Xylanase inhibitor N-terminal TAXi_C PF14541.1 EWC48955.1 - 8.6e-05 22.1 0.0 0.00017 21.1 0.0 1.5 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.1 EWC48955.1 - 0.00024 21.5 0.9 0.24 11.9 0.3 3.2 2 1 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.1 EWC48955.1 - 0.064 13.0 0.0 5.1 7.0 0.0 2.5 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease Abhydrolase_6 PF12697.2 EWC48956.1 - 6.3e-22 78.5 0.8 5.2e-21 75.5 0.5 2.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EWC48956.1 - 1.1e-10 41.4 0.0 0.00023 20.9 0.0 2.6 2 0 0 2 2 2 2 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EWC48956.1 - 4.3e-10 39.5 0.0 3.5e-09 36.5 0.0 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold DLH PF01738.13 EWC48956.1 - 0.0022 17.3 0.0 0.0048 16.1 0.0 1.5 1 0 0 1 1 1 1 Dienelactone hydrolase family Peptidase_S9 PF00326.16 EWC48956.1 - 0.0059 15.8 0.0 0.055 12.6 0.0 2.1 2 0 0 2 2 2 1 Prolyl oligopeptidase family Fungal_trans PF04082.13 EWC48957.1 - 5.1e-25 87.8 0.1 3.8e-22 78.4 0.0 2.3 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.13 EWC48957.1 - 9.9e-07 28.5 7.5 1.8e-06 27.7 5.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Tropomyosin PF00261.15 EWC48957.1 - 0.27 10.2 1.6 0.46 9.5 0.3 1.7 2 0 0 2 2 2 0 Tropomyosin DUF2360 PF10152.4 EWC48957.1 - 0.37 11.0 2.2 0.33 11.2 0.2 1.9 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein (DUF2360) Ribosomal_S30 PF04758.9 EWC48958.1 - 5.6e-30 102.8 6.8 6.6e-30 102.6 4.7 1.0 1 0 0 1 1 1 1 Ribosomal protein S30 Cyt-b5 PF00173.23 EWC48959.1 - 2.9e-07 30.1 0.1 3.8e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain HLH PF00010.21 EWC48960.1 - 3.1e-16 58.8 1.3 3.1e-16 58.8 0.9 1.6 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain DUF4200 PF13863.1 EWC48960.1 - 0.011 15.6 2.2 0.02 14.8 1.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) BOP1NT PF08145.7 EWC48961.1 - 5.6e-106 354.0 4.3 7.5e-106 353.6 3.0 1.2 1 0 0 1 1 1 1 BOP1NT (NUC169) domain WD40 PF00400.27 EWC48961.1 - 3.7e-34 115.3 4.9 1.8e-10 40.2 0.1 7.4 7 0 0 7 7 7 5 WD domain, G-beta repeat Daxx PF03344.10 EWC48961.1 - 0.6 8.5 11.5 0.86 8.0 8.0 1.1 1 0 0 1 1 1 0 Daxx Family Fungal_trans PF04082.13 EWC48962.1 - 6.9e-22 77.5 1.3 1e-21 76.9 0.9 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EWC48962.1 - 5.6e-09 35.7 10.6 9e-09 35.1 7.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 EWC48963.1 - 2.8e-26 91.9 0.1 4.6e-26 91.2 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EWC48963.1 - 1e-08 34.9 11.9 2e-08 34.0 8.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PhoD PF09423.5 EWC48965.1 - 8.6e-136 453.0 5.7 9.9e-136 452.8 3.9 1.0 1 0 0 1 1 1 1 PhoD-like phosphatase zf-CCCH PF00642.19 EWC48966.1 - 1.6e-05 24.4 10.2 0.014 15.0 2.8 2.5 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Acyl-CoA_dh_1 PF00441.19 EWC48967.1 - 6.3e-31 107.5 0.2 9e-31 107.0 0.2 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.14 EWC48967.1 - 6.2e-19 67.2 1.3 1.3e-18 66.2 0.9 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.11 EWC48967.1 - 1.3e-08 35.3 0.5 6.4e-08 33.1 0.0 2.4 2 1 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.6 EWC48967.1 - 1.5e-06 28.5 0.2 2.4e-06 27.8 0.1 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain SNF5 PF04855.7 EWC48968.1 - 2e-43 148.6 0.0 9.7e-43 146.3 0.0 1.9 1 1 0 1 1 1 1 SNF5 / SMARCB1 / INI1 GATA PF00320.22 EWC48968.1 - 9.5e-05 21.6 0.5 0.00025 20.3 0.1 2.0 1 1 0 1 1 1 1 GATA zinc finger RRM_1 PF00076.17 EWC48969.1 - 4.4e-62 205.6 0.0 6.8e-19 67.2 0.0 5.3 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EWC48969.1 - 1.3e-46 156.4 0.0 4.4e-15 55.4 0.0 5.3 5 0 0 5 5 5 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EWC48969.1 - 3.1e-24 84.5 0.0 4.3e-13 48.8 0.0 3.6 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM PF05172.8 EWC48969.1 - 0.064 13.0 0.0 1.1 9.0 0.0 2.3 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif VPS9 PF02204.13 EWC48970.1 - 8.7e-29 99.6 0.0 1.4e-28 98.9 0.0 1.4 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain CUE PF02845.11 EWC48970.1 - 8.2e-08 31.5 0.0 1.9e-07 30.4 0.0 1.7 1 0 0 1 1 1 1 CUE domain MARVEL PF01284.18 EWC48971.1 - 1.3e-05 25.0 26.4 1.7e-05 24.6 18.3 1.1 1 0 0 1 1 1 1 Membrane-associating domain AAA PF00004.24 EWC48972.1 - 1.5e-15 57.5 0.0 4.8e-15 55.9 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 EWC48972.1 - 0.003 17.6 0.3 0.32 11.1 0.1 2.8 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.1 EWC48972.1 - 0.0085 16.0 1.4 0.029 14.3 0.0 2.3 1 1 0 2 2 2 1 AAA ATPase domain Zot PF05707.7 EWC48972.1 - 0.016 14.6 0.1 0.63 9.4 0.0 2.5 1 1 1 2 2 2 0 Zonular occludens toxin (Zot) AAA_5 PF07728.9 EWC48972.1 - 0.041 13.5 0.0 0.12 12.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) KaiC PF06745.8 EWC48972.1 - 0.1 11.7 1.4 0.24 10.5 0.1 2.2 3 0 0 3 3 3 0 KaiC CFEM PF05730.6 EWC48973.1 - 1.4e-06 28.0 4.5 2.4e-06 27.2 3.1 1.3 1 0 0 1 1 1 1 CFEM domain AAA_2 PF07724.9 EWC48974.1 - 9.1e-49 165.6 0.0 2.2e-47 161.1 0.0 2.6 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) ClpB_D2-small PF10431.4 EWC48974.1 - 6.4e-23 80.4 0.5 2e-22 78.8 0.3 1.9 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.24 EWC48974.1 - 2.4e-22 79.5 0.0 3.3e-12 46.7 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 EWC48974.1 - 4.3e-15 55.6 0.0 5.7e-10 39.0 0.0 3.2 3 0 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 EWC48974.1 - 2.6e-14 53.6 3.3 1.5e-05 25.0 0.0 4.4 3 2 2 5 5 5 2 AAA ATPase domain AAA_22 PF13401.1 EWC48974.1 - 2.4e-11 43.9 0.0 0.00015 21.8 0.0 3.2 2 1 0 2 2 2 2 AAA domain Arch_ATPase PF01637.13 EWC48974.1 - 8.9e-10 38.6 3.0 0.0024 17.6 0.0 4.5 3 3 1 4 4 4 3 Archaeal ATPase AAA_14 PF13173.1 EWC48974.1 - 4.8e-08 32.9 0.0 0.01 15.7 0.0 3.0 3 0 0 3 3 3 2 AAA domain AAA_17 PF13207.1 EWC48974.1 - 8.5e-08 33.0 0.1 0.0096 16.7 0.0 3.3 3 0 0 3 3 2 2 AAA domain Sigma54_activat PF00158.21 EWC48974.1 - 5.6e-07 29.1 0.3 0.00051 19.5 0.0 3.1 3 0 0 3 3 3 1 Sigma-54 interaction domain NACHT PF05729.7 EWC48974.1 - 4.1e-06 26.5 0.0 0.032 13.8 0.0 2.8 2 1 0 2 2 2 2 NACHT domain AAA_18 PF13238.1 EWC48974.1 - 5.9e-06 26.6 0.3 0.0065 16.7 0.0 3.0 3 0 0 3 3 2 1 AAA domain IstB_IS21 PF01695.12 EWC48974.1 - 8.3e-06 25.3 0.0 0.03 13.7 0.0 2.6 2 0 0 2 2 2 2 IstB-like ATP binding protein MobB PF03205.9 EWC48974.1 - 1.3e-05 24.8 0.0 0.15 11.7 0.0 2.6 2 0 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B AAA_28 PF13521.1 EWC48974.1 - 0.00013 21.9 0.1 1.4 8.8 0.0 3.7 4 1 0 4 4 3 2 AAA domain DUF258 PF03193.11 EWC48974.1 - 0.00018 20.7 0.0 0.21 10.7 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 T2SE PF00437.15 EWC48974.1 - 0.00031 19.7 0.2 0.01 14.7 0.1 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_25 PF13481.1 EWC48974.1 - 0.00036 19.9 0.0 1.4 8.3 0.0 2.7 2 1 0 2 2 2 2 AAA domain TrwB_AAD_bind PF10412.4 EWC48974.1 - 0.00038 19.1 0.0 0.34 9.4 0.0 2.9 3 0 0 3 3 3 1 Type IV secretion-system coupling protein DNA-binding domain RNA_helicase PF00910.17 EWC48974.1 - 0.00045 20.3 0.0 1.4 9.1 0.0 2.8 2 0 0 2 2 2 2 RNA helicase AAA_19 PF13245.1 EWC48974.1 - 0.00075 19.2 0.2 0.27 11.0 0.0 3.3 3 0 0 3 3 3 1 Part of AAA domain ResIII PF04851.10 EWC48974.1 - 0.00076 19.3 0.2 5.4 6.7 0.0 3.8 4 0 0 4 4 4 0 Type III restriction enzyme, res subunit SRP54 PF00448.17 EWC48974.1 - 0.00079 18.9 0.0 1.3 8.4 0.0 3.2 3 0 0 3 3 3 1 SRP54-type protein, GTPase domain ABC_tran PF00005.22 EWC48974.1 - 0.0011 19.2 0.2 1.7 8.9 0.0 3.1 3 0 0 3 3 3 1 ABC transporter AAA_33 PF13671.1 EWC48974.1 - 0.0012 18.6 0.0 0.94 9.3 0.0 3.0 3 0 0 3 3 2 1 AAA domain NB-ARC PF00931.17 EWC48974.1 - 0.0016 17.3 0.1 0.77 8.5 0.0 3.2 2 1 1 3 3 3 1 NB-ARC domain Mg_chelatase PF01078.16 EWC48974.1 - 0.0025 17.0 0.0 0.62 9.1 0.0 2.6 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Miro PF08477.8 EWC48974.1 - 0.0042 17.5 0.2 1.2 9.6 0.0 2.8 3 0 0 3 3 2 1 Miro-like protein AAA_30 PF13604.1 EWC48974.1 - 0.0043 16.6 0.5 1.7 8.2 0.0 3.9 3 1 1 4 4 4 1 AAA domain ATP_bind_1 PF03029.12 EWC48974.1 - 0.0062 16.0 0.0 3.1 7.2 0.0 2.5 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein AAA_24 PF13479.1 EWC48974.1 - 0.0076 15.8 0.0 3.6 7.1 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_10 PF12846.2 EWC48974.1 - 0.012 15.0 2.8 0.25 10.7 0.0 3.4 3 1 1 4 4 3 0 AAA-like domain Zeta_toxin PF06414.7 EWC48974.1 - 0.014 14.4 0.0 2 7.4 0.0 2.7 2 0 0 2 2 2 0 Zeta toxin AAA_29 PF13555.1 EWC48974.1 - 0.017 14.6 0.0 3.4 7.2 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain NTPase_1 PF03266.10 EWC48974.1 - 0.042 13.5 0.2 8 6.1 0.0 3.0 3 0 0 3 3 2 0 NTPase cobW PF02492.14 EWC48974.1 - 0.052 12.9 0.0 6 6.2 0.0 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain MMR_HSR1 PF01926.18 EWC48974.1 - 0.072 13.0 0.0 17 5.3 0.0 2.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase UPF0079 PF02367.12 EWC48974.1 - 0.083 12.5 0.0 11 5.6 0.0 2.6 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 AAA_23 PF13476.1 EWC48974.1 - 0.61 10.3 16.9 16 5.7 0.0 3.5 2 2 0 2 2 2 0 AAA domain Glutaredoxin PF00462.19 EWC48975.1 - 5.3e-14 51.9 0.0 1.6e-13 50.4 0.0 1.8 2 0 0 2 2 2 1 Glutaredoxin GST_N_3 PF13417.1 EWC48975.1 - 0.006 16.7 0.0 0.012 15.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Peptidase_S49_N PF08496.5 EWC48975.1 - 0.0079 16.0 0.5 0.016 15.0 0.3 1.4 1 0 0 1 1 1 1 Peptidase family S49 N-terminal Thioredoxin_7 PF13899.1 EWC48975.1 - 0.028 14.4 0.0 0.091 12.7 0.0 1.9 1 1 0 1 1 1 0 Thioredoxin-like Histone_HNS PF00816.16 EWC48975.1 - 0.066 13.7 1.8 0.12 12.8 1.2 1.4 1 0 0 1 1 1 0 H-NS histone family Iron_permease PF04120.7 EWC48975.1 - 0.086 12.4 0.1 0.13 11.8 0.1 1.2 1 0 0 1 1 1 0 Low affinity iron permease DSBA PF01323.15 EWC48975.1 - 0.61 9.6 5.7 6.3 6.2 0.0 2.9 2 1 1 3 3 3 0 DSBA-like thioredoxin domain DUF3987 PF13148.1 EWC48975.1 - 4.6 5.7 6.4 6.2 5.2 4.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) ORMDL PF04061.9 EWC48976.1 - 2.3e-56 189.1 4.1 2.7e-56 188.8 2.8 1.1 1 0 0 1 1 1 1 ORMDL family Med1 PF10744.4 EWC48977.1 - 7.1e-26 90.8 0.0 6.6e-25 87.7 0.0 2.1 1 1 0 1 1 1 1 Mediator of RNA polymerase II transcription subunit 1 Vezatin PF12632.2 EWC48977.1 - 0.16 11.0 0.0 0.29 10.1 0.0 1.3 1 0 0 1 1 1 0 Mysoin-binding motif of peroxisomes Sod_Cu PF00080.15 EWC48978.1 - 6.9e-14 52.1 0.1 9.8e-14 51.7 0.0 1.3 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) DUF3108 PF11306.3 EWC48978.1 - 0.11 12.1 0.4 0.17 11.4 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3108)