# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- MR_MLE_C PF13378.6 ADV19300.1 - 2.7e-43 148.1 0.0 3.8e-43 147.6 0.0 1.1 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 ADV19300.1 - 2.8e-10 40.4 0.0 4.5e-10 39.8 0.0 1.3 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain Dynactin_p62 PF05502.13 ADV19301.1 - 0.25 10.1 0.0 0.28 9.9 0.0 1.1 1 0 0 1 1 1 0 Dynactin p62 family Fungal_trans PF04082.18 ADV19302.1 - 1.3e-19 70.3 0.3 2e-19 69.7 0.3 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ADV19302.1 - 1.1e-07 31.8 11.7 2e-07 31.0 11.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sugar_tr PF00083.24 ADV19303.1 - 1e-65 222.4 25.8 1.2e-65 222.2 25.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ADV19303.1 - 2.5e-18 66.1 46.7 2e-14 53.3 27.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1689 PF07954.11 ADV19303.1 - 0.057 13.8 0.3 1.7 9.1 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1689) Clat_adaptor_s PF01217.20 ADV19304.1 - 1.2e-11 44.8 0.0 2.7e-08 33.8 0.0 2.1 2 0 0 2 2 2 2 Clathrin adaptor complex small chain EMP24_GP25L PF01105.24 ADV19307.1 - 4.4 7.2 4.7 7.4 6.5 4.7 1.4 1 1 0 1 1 1 0 emp24/gp25L/p24 family/GOLD SHNi-TPR PF10516.9 ADV19308.1 - 1.1e-14 53.6 0.0 2e-14 52.7 0.0 1.5 1 0 0 1 1 1 1 SHNi-TPR TPR_12 PF13424.6 ADV19308.1 - 9.3e-05 22.6 0.5 0.42 10.9 0.0 2.8 2 1 0 2 2 2 2 Tetratricopeptide repeat Uso1_p115_C PF04871.13 ADV19308.1 - 0.011 16.1 1.2 0.011 16.1 1.2 2.8 3 0 0 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region TPR_2 PF07719.17 ADV19308.1 - 0.051 13.7 0.1 0.74 10.1 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat UPF0242 PF06785.11 ADV19308.1 - 0.057 13.5 0.2 0.091 12.9 0.2 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Allexi_40kDa PF05549.11 ADV19308.1 - 0.16 11.5 0.3 0.26 10.7 0.3 1.3 1 0 0 1 1 1 0 Allexivirus 40kDa protein TPR_19 PF14559.6 ADV19308.1 - 0.19 12.3 2.6 19 5.8 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat Mpp10 PF04006.12 ADV19309.1 - 8.9e-111 371.3 59.0 3.7e-104 349.4 49.5 2.1 1 1 1 2 2 2 2 Mpp10 protein TFIIA PF03153.13 ADV19309.1 - 0.00062 19.9 22.3 0.00062 19.9 22.3 3.2 2 1 0 3 3 3 1 Transcription factor IIA, alpha/beta subunit PepSY_2 PF13670.6 ADV19309.1 - 0.066 13.2 1.2 2.6 8.1 0.0 3.4 2 1 1 3 3 3 0 Peptidase propeptide and YPEB domain CCDC71L PF15374.6 ADV19309.1 - 0.32 10.2 9.6 0.019 14.3 3.9 1.7 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 71L Coatomer_WDAD PF04053.14 ADV19310.1 - 1.5e-153 512.0 0.0 2.7e-153 511.2 0.0 1.4 2 0 0 2 2 2 1 Coatomer WD associated region WD40 PF00400.32 ADV19310.1 - 4.3e-36 122.3 16.5 8.5e-06 26.4 0.2 9.9 10 0 0 10 10 10 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV19310.1 - 1e-09 38.6 0.2 0.077 13.3 0.0 7.0 3 2 7 10 10 10 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 ADV19310.1 - 6.8e-05 22.6 1.3 0.045 13.3 0.4 2.9 3 0 0 3 3 3 2 PQQ-like domain PQQ PF01011.21 ADV19310.1 - 0.00028 20.7 0.3 1.4 9.0 0.0 3.7 3 0 0 3 3 3 2 PQQ enzyme repeat Nup160 PF11715.8 ADV19310.1 - 0.0015 17.3 2.1 3.2 6.3 0.0 4.0 3 2 1 4 4 4 3 Nucleoporin Nup120/160 UPF0113_N PF17833.1 ADV19311.1 - 3.8e-29 101.1 0.0 6.1e-29 100.4 0.0 1.3 1 0 0 1 1 1 1 UPF0113 Pre-PUA domain UPF0113 PF03657.13 ADV19311.1 - 1e-24 86.6 0.0 1.6e-24 85.9 0.0 1.3 1 0 0 1 1 1 1 UPF0113 PUA domain RNA12 PF10443.9 ADV19312.1 - 7e-161 535.9 0.4 1.1e-160 535.2 0.4 1.3 1 1 0 1 1 1 1 RNA12 protein RRM_1 PF00076.22 ADV19312.1 - 2e-05 24.3 0.0 6e-05 22.8 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ATPase_2 PF01637.18 ADV19312.1 - 3.7e-05 23.8 0.0 0.00015 21.8 0.0 2.0 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea AAA_22 PF13401.6 ADV19312.1 - 0.00046 20.5 0.0 0.00098 19.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain cobW PF02492.19 ADV19312.1 - 0.00073 19.2 0.0 0.0013 18.3 0.0 1.4 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_16 PF13191.6 ADV19312.1 - 0.00084 19.8 0.0 0.0019 18.6 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_24 PF13479.6 ADV19312.1 - 0.0064 16.2 0.0 0.012 15.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 ADV19312.1 - 0.0086 16.5 0.0 0.019 15.4 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 ADV19312.1 - 0.0095 16.1 0.0 0.022 14.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain NTPase_1 PF03266.15 ADV19312.1 - 0.02 14.8 0.2 0.098 12.6 0.0 2.2 3 0 0 3 3 3 0 NTPase DUF3987 PF13148.6 ADV19312.1 - 0.033 13.2 0.0 0.077 12.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) RsgA_GTPase PF03193.16 ADV19312.1 - 0.05 13.5 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_35 PF14516.6 ADV19312.1 - 0.06 12.2 0.0 0.11 11.3 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain NB-ARC PF00931.22 ADV19312.1 - 0.069 12.3 0.0 0.15 11.2 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain AAA_18 PF13238.6 ADV19312.1 - 0.1 13.2 0.0 0.33 11.5 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 ADV19312.1 - 0.11 12.2 0.0 0.31 10.8 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 ADV19312.1 - 0.14 12.7 0.0 0.45 11.0 0.0 1.9 1 0 0 1 1 1 0 ABC transporter Viral_helicase1 PF01443.18 ADV19312.1 - 0.2 11.4 0.0 0.42 10.3 0.0 1.5 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Ribosomal_L28e PF01778.17 ADV19313.1 - 5.3e-25 88.4 0.1 7.3e-25 88.0 0.1 1.2 1 0 0 1 1 1 1 Ribosomal L28e protein family Ribonuc_L-PSP PF01042.21 ADV19314.1 - 2.7e-41 140.4 0.0 3.2e-41 140.1 0.0 1.1 1 0 0 1 1 1 1 Endoribonuclease L-PSP DUF2076 PF09849.9 ADV19315.1 - 1.2e-06 28.8 11.1 1.4e-06 28.5 11.1 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) CHCH PF06747.13 ADV19315.1 - 2.1e-05 24.5 2.7 3e-05 24.0 2.7 1.2 1 0 0 1 1 1 1 CHCH domain MTCP1 PF08991.10 ADV19315.1 - 0.034 14.4 1.7 0.058 13.6 1.7 1.3 1 0 0 1 1 1 0 Mature-T-Cell Proliferation I type CX9C PF16860.5 ADV19315.1 - 0.058 13.4 1.4 0.086 12.9 1.4 1.3 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Rick_17kDa_Anti PF05433.15 ADV19315.1 - 0.17 11.8 4.6 0.3 11.0 4.6 1.4 1 0 0 1 1 1 0 Glycine zipper 2TM domain Rdx PF10262.9 ADV19316.1 - 3.7e-26 91.1 0.0 6.5e-26 90.3 0.0 1.4 1 0 0 1 1 1 1 Rdx family Glutaredoxin PF00462.24 ADV19318.1 - 4.5e-10 39.6 0.0 1.1e-09 38.3 0.0 1.7 1 0 0 1 1 1 1 Glutaredoxin Rad1 PF02144.16 ADV19319.1 - 2.6e-84 282.5 0.0 3e-84 282.3 0.0 1.0 1 0 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 rRNA_processing PF08524.11 ADV19320.1 - 2.7e-09 37.2 14.2 0.00029 20.9 8.1 2.7 2 1 0 2 2 2 2 rRNA processing MCM PF00493.23 ADV19321.1 - 3.4e-104 346.8 0.0 4.8e-104 346.3 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 ADV19321.1 - 8.1e-35 119.4 0.0 1.6e-34 118.4 0.0 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 ADV19321.1 - 6e-28 97.1 0.2 1.6e-27 95.8 0.2 1.8 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 ADV19321.1 - 1.5e-17 64.1 0.1 3.7e-17 62.8 0.1 1.7 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 ADV19321.1 - 3.4e-06 26.6 0.0 0.00067 19.1 0.0 2.4 1 1 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 ADV19321.1 - 3.6e-05 23.8 0.0 0.0001 22.3 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 ADV19321.1 - 0.002 18.0 0.1 0.0097 15.8 0.0 2.2 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 ADV19321.1 - 0.05 13.3 0.0 1.5 8.5 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA PF00004.29 ADV19321.1 - 0.083 13.3 0.0 0.55 10.7 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Mg_chelatase_C PF13335.6 ADV19321.1 - 0.41 11.3 3.0 0.51 11.0 0.1 2.7 4 0 0 4 4 4 0 Magnesium chelatase, subunit ChlI C-terminal LSM PF01423.22 ADV19322.1 - 3.8e-16 58.5 0.3 4.8e-16 58.2 0.3 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 ADV19322.1 - 0.038 14.1 0.0 0.06 13.5 0.0 1.3 1 0 0 1 1 1 0 Ataxin 2 SM domain Actin PF00022.19 ADV19323.1 - 7.5e-141 469.4 0.0 8.7e-141 469.2 0.0 1.0 1 0 0 1 1 1 1 Actin TMEM208_SND2 PF05620.11 ADV19324.1 - 7.9e-47 159.2 0.1 9.4e-47 158.9 0.1 1.1 1 0 0 1 1 1 1 SRP-independent targeting protein 2/TMEM208 DUF4010 PF13194.6 ADV19324.1 - 0.02 14.6 0.2 0.029 14.0 0.2 1.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4010) U3_assoc_6 PF08640.11 ADV19325.1 - 2.7e-30 104.2 3.5 4.9e-28 97.0 2.2 3.4 4 0 0 4 4 4 1 U3 small nucleolar RNA-associated protein 6 TPR_14 PF13428.6 ADV19325.1 - 0.016 16.0 0.0 27 5.9 0.0 3.7 2 1 1 3 3 3 0 Tetratricopeptide repeat NRDE-2 PF08424.10 ADV19325.1 - 0.08 12.1 0.0 0.27 10.3 0.0 1.7 2 0 0 2 2 2 0 NRDE-2, necessary for RNA interference AdoMet_Synthase PF01941.19 ADV19325.1 - 0.1 11.4 0.0 0.13 11.0 0.0 1.1 1 0 0 1 1 1 0 S-adenosylmethionine synthetase (AdoMet synthetase) Fungal_trans PF04082.18 ADV19326.1 - 1.5e-09 37.3 0.0 3.5e-09 36.1 0.0 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ADV19326.1 - 0.00051 20.1 10.9 0.00087 19.4 10.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Nitrate_red_del PF02613.15 ADV19326.1 - 0.067 13.2 0.0 0.27 11.2 0.0 2.0 2 0 0 2 2 2 0 Nitrate reductase delta subunit Macoilin PF09726.9 ADV19326.1 - 0.39 9.2 4.7 0.61 8.6 4.7 1.2 1 0 0 1 1 1 0 Macoilin family TetR_N PF00440.23 ADV19326.1 - 1.7 8.5 4.2 20 5.1 0.1 3.2 4 0 0 4 4 4 0 Bacterial regulatory proteins, tetR family Sugar_tr PF00083.24 ADV19327.1 - 6.9e-103 344.9 20.2 8.2e-103 344.7 20.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ADV19327.1 - 6.4e-20 71.4 26.1 6.4e-20 71.4 26.1 2.3 1 1 1 2 2 2 1 Major Facilitator Superfamily DUF2423 PF10338.9 ADV19328.1 - 1.9e-13 50.4 10.8 1.9e-13 50.4 10.8 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2423) Peptidase_M41 PF01434.18 ADV19329.1 - 8e-63 211.7 0.0 1.2e-62 211.1 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 ADV19329.1 - 3.5e-43 147.2 0.4 1.2e-42 145.5 0.0 2.1 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ADV19329.1 - 7.4e-15 54.5 0.2 2.3e-14 52.9 0.2 1.8 1 0 0 1 1 1 1 AAA+ lid domain FtsH_ext PF06480.15 ADV19329.1 - 1.7e-07 31.6 0.0 3.4e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 FtsH Extracellular TIP49 PF06068.13 ADV19329.1 - 0.0024 17.1 0.0 0.0038 16.5 0.0 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_16 PF13191.6 ADV19329.1 - 0.008 16.6 0.2 0.15 12.4 0.2 2.5 1 1 0 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 ADV19329.1 - 0.011 15.5 0.0 0.021 14.6 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 ADV19329.1 - 0.027 14.8 0.0 0.72 10.1 0.1 2.6 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 ADV19329.1 - 0.031 14.3 0.0 0.1 12.6 0.0 2.0 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_17 PF13207.6 ADV19329.1 - 0.053 14.0 0.5 0.14 12.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_2 PF07724.14 ADV19329.1 - 0.1 12.7 0.3 0.49 10.5 0.0 2.2 2 1 0 2 2 2 0 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.17 ADV19329.1 - 0.15 11.8 0.0 0.28 10.9 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein Mg_chelatase PF01078.21 ADV19329.1 - 0.22 10.9 0.7 0.57 9.5 0.3 1.8 1 1 1 2 2 2 0 Magnesium chelatase, subunit ChlI p450 PF00067.22 ADV19330.1 - 2.4e-42 145.2 0.0 4.3e-42 144.4 0.0 1.4 1 1 0 1 1 1 1 Cytochrome P450 Cue1_U7BR PF18499.1 ADV19330.1 - 0.052 13.6 1.2 0.11 12.6 1.2 1.5 1 0 0 1 1 1 0 Ubc7p-binding region of Cue1 DUF4808 PF16066.5 ADV19331.1 - 0.94 10.0 2.4 2.5 8.6 2.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4808) Helicase_C_2 PF13307.6 ADV19332.1 - 1.9e-50 171.4 0.0 7e-50 169.5 0.0 2.0 2 0 0 2 2 2 1 Helicase C-terminal domain DEAD_2 PF06733.15 ADV19332.1 - 4.6e-44 150.1 0.2 8.5e-44 149.3 0.2 1.5 1 0 0 1 1 1 1 DEAD_2 AAA_22 PF13401.6 ADV19332.1 - 0.00049 20.4 0.0 0.8 10.0 0.0 3.4 3 0 0 3 3 3 2 AAA domain DEAD PF00270.29 ADV19332.1 - 0.0045 16.8 1.4 0.12 12.2 1.4 2.4 1 1 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 ADV19332.1 - 0.0099 15.9 0.0 2.4 8.1 0.0 2.5 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit SpecificRecomb PF10136.9 ADV19332.1 - 0.067 11.5 0.3 0.11 10.8 0.3 1.2 1 0 0 1 1 1 0 Site-specific recombinase PhoH PF02562.16 ADV19332.1 - 0.1 12.0 0.1 5.9 6.3 0.0 2.4 2 0 0 2 2 2 0 PhoH-like protein Sugar_tr PF00083.24 ADV19333.1 - 5.5e-94 315.6 29.3 6.8e-94 315.3 29.3 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ADV19333.1 - 4.3e-17 62.1 43.8 1.8e-11 43.6 17.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3021 PF11457.8 ADV19333.1 - 1 9.7 17.5 0.039 14.3 3.7 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3021) Zn_clus PF00172.18 ADV19334.1 - 2.6e-08 33.8 10.2 4e-08 33.2 10.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ribosomal_L26 PF16906.5 ADV19336.1 - 4.9e-35 119.9 3.7 6.1e-35 119.6 3.7 1.1 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal KOW PF00467.29 ADV19336.1 - 7.5e-10 38.4 3.7 1.5e-09 37.4 3.7 1.6 1 0 0 1 1 1 1 KOW motif DEAD PF00270.29 ADV19337.1 - 4.7e-12 46.0 0.0 1.5e-11 44.4 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ADV19337.1 - 7.6e-07 29.5 0.0 8.3e-06 26.1 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HalX PF08663.10 ADV19337.1 - 0.11 12.8 0.2 0.23 11.8 0.2 1.4 1 0 0 1 1 1 0 HalX domain Anti-adapt_IraP PF10796.9 ADV19337.1 - 0.48 11.0 3.9 1.2 9.8 0.2 2.4 2 0 0 2 2 2 0 Sigma-S stabilisation anti-adaptor protein LPP PF04728.13 ADV19337.1 - 1.8 9.0 3.5 24 5.4 0.0 2.7 2 0 0 2 2 2 0 Lipoprotein leucine-zipper Siah-Interact_N PF09032.11 ADV19337.1 - 2.4 8.5 4.4 6.7 7.1 4.4 1.8 1 1 0 1 1 1 0 Siah interacting protein, N terminal TFIIA PF03153.13 ADV19337.1 - 8.4 6.3 13.3 0.59 10.1 8.3 1.5 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit TAL_FSA PF00923.19 ADV19338.1 - 1.9e-33 116.1 0.0 2.3e-33 115.8 0.0 1.2 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase RRM_1 PF00076.22 ADV19339.1 - 2.9e-21 75.0 0.8 1.3e-09 37.7 0.1 2.9 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_Rrp7 PF17799.1 ADV19339.1 - 0.022 14.5 0.0 0.046 13.5 0.0 1.5 1 0 0 1 1 1 0 Rrp7 RRM-like N-terminal domain SLC12 PF03522.15 ADV19339.1 - 0.47 9.4 4.6 0.71 8.8 4.6 1.2 1 0 0 1 1 1 0 Solute carrier family 12 SRP-alpha_N PF04086.13 ADV19339.1 - 0.61 10.0 20.1 1.2 9.0 20.1 1.5 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Nop14 PF04147.12 ADV19339.1 - 0.87 7.7 20.6 1.3 7.1 20.6 1.2 1 0 0 1 1 1 0 Nop14-like family Borrelia_P83 PF05262.11 ADV19339.1 - 4.9 5.5 20.6 5.7 5.3 20.6 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein FtsJ PF01728.19 ADV19340.1 - 2.1e-46 158.2 0.0 2.5e-46 158.0 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase Glyco_hydro_31 PF01055.26 ADV19341.1 - 3e-135 451.8 2.3 4e-135 451.4 2.3 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 ADV19341.1 - 6.2e-18 64.9 0.1 2.2e-17 63.1 0.1 2.1 1 0 0 1 1 1 1 Galactose mutarotase-like DUF5110 PF17137.4 ADV19341.1 - 4.7e-05 23.6 0.0 0.00014 22.1 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) RrnaAD PF00398.20 ADV19342.1 - 2.3e-15 56.4 0.0 1.5e-06 27.5 0.0 3.1 3 0 0 3 3 3 3 Ribosomal RNA adenine dimethylase HSF_DNA-bind PF00447.17 ADV19343.1 - 1.3e-19 70.6 0.0 2.2e-19 69.9 0.0 1.4 1 0 0 1 1 1 1 HSF-type DNA-binding NifU_N PF01592.16 ADV19345.1 - 2e-51 173.4 1.7 4.8e-51 172.2 0.1 1.9 2 0 0 2 2 2 1 NifU-like N terminal domain Pkinase PF00069.25 ADV19346.1 - 3.6e-71 239.6 0.0 4.9e-71 239.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV19346.1 - 1.1e-28 100.3 0.1 8.3e-21 74.4 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 ADV19346.1 - 2.3e-08 33.7 0.3 0.16 11.3 0.0 3.1 3 0 0 3 3 3 3 Kinase-like Pkinase_fungal PF17667.1 ADV19346.1 - 0.0017 17.2 1.4 0.0052 15.6 0.0 2.2 2 1 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 ADV19346.1 - 0.065 12.6 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family GFA PF04828.14 ADV19348.1 - 3.1e-18 65.9 0.3 4.1e-18 65.5 0.3 1.2 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme DNA_pol_A_exo1 PF01612.20 ADV19350.1 - 4.2e-12 46.1 0.0 1.3e-11 44.5 0.0 1.8 2 0 0 2 2 2 1 3'-5' exonuclease HTH_40 PF14493.6 ADV19350.1 - 0.012 16.1 0.5 0.026 15.0 0.5 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain TPR_1 PF00515.28 ADV19351.1 - 1.1e-08 34.5 1.7 0.0074 16.1 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 ADV19351.1 - 7.2e-08 32.0 2.5 0.0056 16.7 0.3 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 ADV19351.1 - 4e-05 23.2 0.7 0.00071 19.2 0.1 2.7 2 1 1 3 3 3 1 TPR repeat TPR_17 PF13431.6 ADV19351.1 - 0.00013 22.1 1.6 0.29 11.6 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ADV19351.1 - 0.00015 21.8 0.8 0.0019 18.3 0.1 2.4 1 1 1 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat TPR_9 PF13371.6 ADV19351.1 - 0.00019 21.5 0.1 0.0024 18.0 0.1 2.3 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 ADV19351.1 - 0.0059 16.7 1.4 5.1 7.6 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 ADV19351.1 - 0.0081 16.9 0.1 5.5 8.1 0.1 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 ADV19351.1 - 0.013 16.0 0.5 1.2 9.7 0.2 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 ADV19351.1 - 0.014 15.7 1.6 3 8.2 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 ADV19351.1 - 0.11 13.2 0.1 16 6.2 0.0 2.7 1 1 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 ADV19351.1 - 0.46 10.4 2.3 31 4.6 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_20 PF14561.6 ADV19351.1 - 1.7 9.0 3.7 0.47 10.8 0.2 1.8 2 0 0 2 2 1 0 Tetratricopeptide repeat HA2 PF04408.23 ADV19352.1 - 2.8e-18 66.2 0.0 2.8e-18 66.2 0.0 3.2 3 0 0 3 3 3 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 ADV19352.1 - 9.1e-15 54.8 0.0 2e-14 53.7 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 ADV19352.1 - 3.2e-12 46.8 0.0 8.6e-12 45.4 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 ADV19352.1 - 9.9e-08 31.9 0.0 2e-07 31.0 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase RWD PF05773.22 ADV19352.1 - 0.00082 19.6 0.0 0.002 18.4 0.0 1.6 1 0 0 1 1 1 1 RWD domain ABC_tran PF00005.27 ADV19352.1 - 0.00086 19.8 0.0 0.019 15.5 0.0 2.6 2 0 0 2 2 2 1 ABC transporter AAA_22 PF13401.6 ADV19352.1 - 0.003 17.8 0.0 0.01 16.1 0.0 1.9 1 1 0 1 1 1 1 AAA domain dsrm PF00035.26 ADV19352.1 - 0.053 14.2 0.0 0.14 12.9 0.0 1.8 1 0 0 1 1 1 0 Double-stranded RNA binding motif DND1_DSRM PF14709.7 ADV19352.1 - 0.12 12.6 0.2 0.49 10.7 0.2 2.1 1 1 0 1 1 1 0 double strand RNA binding domain from DEAD END PROTEIN 1 RsgA_GTPase PF03193.16 ADV19352.1 - 0.16 11.8 0.0 0.35 10.8 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase NINJA_B PF16136.5 ADV19352.1 - 1.2 9.5 12.7 0.38 11.1 5.0 2.9 2 0 0 2 2 2 0 Putative nuclear localisation signal SUI1 PF01253.22 ADV19354.1 - 2.5e-24 85.6 0.2 4.5e-24 84.8 0.2 1.4 1 0 0 1 1 1 1 Translation initiation factor SUI1 Rhomboid PF01694.22 ADV19355.1 - 8.1e-20 71.4 14.4 8.1e-20 71.4 14.4 1.5 2 0 0 2 2 2 1 Rhomboid family zf-C2H2_6 PF13912.6 ADV19355.1 - 0.22 11.5 0.4 0.49 10.4 0.4 1.5 1 0 0 1 1 1 0 C2H2-type zinc finger NUC153 PF08159.12 ADV19356.1 - 1.3e-11 44.0 0.1 2.6e-11 43.1 0.1 1.5 1 0 0 1 1 1 1 NUC153 domain Nop14 PF04147.12 ADV19356.1 - 0.61 8.2 21.5 0.97 7.6 21.5 1.2 1 0 0 1 1 1 0 Nop14-like family Glyco_tran_28_C PF04101.16 ADV19357.1 - 2.6e-15 56.8 0.0 2.5e-14 53.6 0.0 1.9 1 1 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain HAD_2 PF13419.6 ADV19358.1 - 4.9e-17 62.6 0.0 5e-16 59.3 0.0 2.1 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ADV19358.1 - 8.8e-11 42.5 0.0 4.2e-09 37.0 0.0 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Glutaredoxin PF00462.24 ADV19358.1 - 0.024 14.9 0.0 0.079 13.2 0.0 1.8 2 0 0 2 2 2 0 Glutaredoxin Hydrolase_6 PF13344.6 ADV19358.1 - 0.032 14.3 0.0 1.1 9.4 0.0 2.3 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ADV19358.1 - 0.088 12.9 0.0 0.2 11.8 0.0 1.7 1 0 0 1 1 1 0 HAD-hyrolase-like Nop PF01798.18 ADV19359.1 - 3.8e-68 229.4 0.0 5.8e-68 228.8 0.0 1.3 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin Prp31_C PF09785.9 ADV19359.1 - 1.3e-40 139.1 3.4 3.7e-40 137.6 3.4 1.8 1 0 0 1 1 1 1 Prp31 C terminal domain Alveol-reg_P311 PF11092.8 ADV19359.1 - 0.18 12.0 0.3 0.43 10.7 0.3 1.6 1 0 0 1 1 1 0 Neuronal protein 3.1 (p311) PPR_2 PF13041.6 ADV19360.1 - 2e-28 98.3 1.8 5e-08 33.0 0.0 7.9 7 1 1 8 8 8 4 PPR repeat family PPR PF01535.20 ADV19360.1 - 2e-23 80.9 4.4 0.0042 17.2 0.0 12.3 13 0 0 13 13 13 5 PPR repeat PPR_3 PF13812.6 ADV19360.1 - 2.5e-19 69.1 0.9 2.7e-05 24.1 0.0 6.3 5 1 1 6 6 6 3 Pentatricopeptide repeat domain PPR_1 PF12854.7 ADV19360.1 - 9.8e-12 44.4 0.2 0.039 13.6 0.0 6.6 7 0 0 7 7 7 4 PPR repeat PPR_long PF17177.4 ADV19360.1 - 2.8e-07 30.1 0.0 0.035 13.4 0.0 2.9 2 1 0 2 2 2 2 Pentacotripeptide-repeat region of PRORP DDE_Tnp_1 PF01609.21 ADV19360.1 - 0.027 14.1 0.1 0.058 13.0 0.1 1.5 1 0 0 1 1 1 0 Transposase DDE domain AEP1 PF17049.5 ADV19360.1 - 0.084 11.9 0.0 0.41 9.7 0.0 2.1 2 0 0 2 2 2 0 ATPase expression protein 1 MAF_flag10 PF01973.18 ADV19360.1 - 0.19 11.4 0.0 6.9 6.3 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function DUF115 TPR_14 PF13428.6 ADV19360.1 - 0.23 12.4 15.0 15 6.7 0.0 8.2 9 2 1 10 10 10 0 Tetratricopeptide repeat Proteasome PF00227.26 ADV19361.1 - 1.3e-49 168.3 0.1 1.6e-49 168.0 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 ADV19361.1 - 6.7e-13 48.1 1.8 7.4e-13 47.9 0.1 1.9 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature OST3_OST6 PF04756.13 ADV19365.1 - 2e-94 316.2 0.0 2.3e-94 316.1 0.0 1.0 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin PF00085.20 ADV19365.1 - 0.21 11.6 0.0 0.37 10.8 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin DUF3382 PF11862.8 ADV19365.1 - 1.2 9.5 6.4 0.86 9.9 2.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3382) 3-HAO PF06052.12 ADV19366.1 - 1.7e-56 190.0 0.0 2.1e-56 189.7 0.0 1.1 1 0 0 1 1 1 1 3-hydroxyanthranilic acid dioxygenase Cupin_2 PF07883.11 ADV19366.1 - 2.3e-08 33.6 0.0 4.7e-08 32.6 0.0 1.5 1 1 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 ADV19366.1 - 0.00046 19.8 0.0 0.00063 19.4 0.0 1.2 1 0 0 1 1 1 1 Cupin AraC_binding PF02311.19 ADV19366.1 - 0.0014 18.5 0.0 0.002 18.1 0.0 1.2 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_4 PF08007.12 ADV19366.1 - 0.0087 15.6 0.0 0.0096 15.4 0.0 1.2 1 0 0 1 1 1 1 Cupin superfamily protein ProRS-C_1 PF09180.11 ADV19367.1 - 5e-27 93.9 1.8 1.1e-26 92.9 1.8 1.6 1 0 0 1 1 1 1 Prolyl-tRNA synthetase, C-terminal tRNA-synt_2b PF00587.25 ADV19367.1 - 5.9e-19 68.7 0.0 9.4e-19 68.1 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 ADV19367.1 - 2.5e-14 53.2 0.0 5.3e-14 52.1 0.0 1.6 1 0 0 1 1 1 1 Anticodon binding domain tRNA_edit PF04073.15 ADV19367.1 - 1.9e-08 34.4 0.4 4.4e-08 33.2 0.4 1.6 1 0 0 1 1 1 1 Aminoacyl-tRNA editing domain DUF3760 PF12586.8 ADV19368.1 - 2.1e-09 37.4 0.1 4.1e-09 36.5 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3760) Velvet PF11754.8 ADV19369.1 - 6.7e-20 72.1 0.0 9.3e-12 45.4 0.0 2.5 2 1 1 3 3 3 2 Velvet factor Tctex-1 PF03645.13 ADV19370.1 - 1.2e-06 28.7 0.1 3.1e-06 27.4 0.0 1.6 2 0 0 2 2 2 1 Tctex-1 family Aft1_HRA PF11786.8 ADV19371.1 - 9.7e-28 96.3 10.2 9.7e-28 96.3 10.2 3.3 3 0 0 3 3 3 1 Aft1 HRA domain bZIP_1 PF00170.21 ADV19371.1 - 4.2e-11 42.8 9.1 7.7e-11 41.9 9.1 1.4 1 0 0 1 1 1 1 bZIP transcription factor Aft1_OSA PF11785.8 ADV19371.1 - 1.7e-08 34.8 2.5 3.6e-07 30.5 2.5 3.2 1 1 0 1 1 1 1 Aft1 osmotic stress response (OSM) domain bZIP_2 PF07716.15 ADV19371.1 - 5.5e-07 29.6 10.5 1.2e-06 28.5 10.5 1.6 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 ADV19371.1 - 0.0016 18.9 7.2 0.0045 17.5 7.2 1.8 1 0 0 1 1 1 1 bZIP Maf transcription factor MCC-bdg_PDZ PF10506.9 ADV19371.1 - 0.043 13.8 1.0 0.091 12.8 1.0 1.6 1 0 0 1 1 1 0 PDZ domain of MCC-2 bdg protein for Usher syndrome HALZ PF02183.18 ADV19371.1 - 0.074 13.3 0.2 0.14 12.4 0.2 1.4 1 0 0 1 1 1 0 Homeobox associated leucine zipper COG5 PF10392.9 ADV19371.1 - 0.083 13.1 0.4 0.2 11.8 0.4 1.5 1 0 0 1 1 1 0 Golgi transport complex subunit 5 Phlebovirus_NSM PF07246.11 ADV19371.1 - 0.39 10.0 5.4 0.61 9.4 5.4 1.2 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M FlaC_arch PF05377.11 ADV19371.1 - 0.4 11.1 1.5 0.61 10.5 0.4 1.8 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Jnk-SapK_ap_N PF09744.9 ADV19371.1 - 0.93 9.7 10.1 2.6 8.2 10.1 1.7 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 DivIC PF04977.15 ADV19371.1 - 2.9 7.7 5.2 1.9 8.3 1.9 2.4 3 0 0 3 3 3 0 Septum formation initiator Bac_rhamnosid6H PF17389.2 ADV19373.1 - 5e-18 65.5 0.2 1.1e-17 64.4 0.2 1.4 1 1 0 1 1 1 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Bac_rhamnosid_N PF08531.10 ADV19373.1 - 4.9e-06 26.5 0.0 9.1e-06 25.6 0.0 1.5 1 0 0 1 1 1 1 Alpha-L-rhamnosidase N-terminal domain Glyco_hydro_36 PF17167.4 ADV19373.1 - 0.0011 17.7 0.0 0.0017 17.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase 36 superfamily, catalytic domain Glyco_hydro_2_N PF02837.18 ADV19373.1 - 0.019 14.9 0.0 0.05 13.5 0.0 1.7 1 0 0 1 1 1 0 Glycosyl hydrolases family 2, sugar binding domain adh_short_C2 PF13561.6 ADV19374.1 - 1.1e-59 201.8 0.1 1.4e-59 201.5 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ADV19374.1 - 5.9e-48 162.9 1.2 6.9e-48 162.7 1.2 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ADV19374.1 - 5.6e-13 49.2 1.3 7.7e-13 48.7 1.3 1.1 1 0 0 1 1 1 1 KR domain ABC2_membrane PF01061.24 ADV19375.1 - 9.3e-90 299.6 51.5 3.8e-47 160.4 25.6 2.6 2 0 0 2 2 2 2 ABC-2 type transporter PDR_CDR PF06422.12 ADV19375.1 - 9.2e-41 137.7 4.6 8.5e-34 115.3 0.0 3.7 3 0 0 3 3 3 2 CDR ABC transporter ABC_tran PF00005.27 ADV19375.1 - 1e-37 129.7 0.0 3.2e-17 63.3 0.0 3.6 4 0 0 4 4 3 2 ABC transporter ABC_trans_N PF14510.6 ADV19375.1 - 9.4e-16 58.2 0.1 4.7e-15 56.0 0.1 2.2 2 0 0 2 2 2 1 ABC-transporter N-terminal AAA_25 PF13481.6 ADV19375.1 - 2.4e-07 30.6 0.0 3.1e-05 23.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 ADV19375.1 - 5.6e-06 26.8 0.3 0.0031 17.9 0.1 2.5 2 0 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 ADV19375.1 - 1.2e-05 25.3 0.3 0.00098 19.1 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_30 PF13604.6 ADV19375.1 - 0.00043 20.1 0.8 0.17 11.6 0.1 2.5 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 ADV19375.1 - 0.0011 19.6 0.1 0.18 12.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_21 PF13304.6 ADV19375.1 - 0.0012 18.7 0.2 1.8 8.3 0.0 2.8 2 1 1 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_33 PF13671.6 ADV19375.1 - 0.0025 18.0 0.1 0.31 11.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 ADV19375.1 - 0.0034 17.1 2.1 0.029 14.1 0.3 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA PF00004.29 ADV19375.1 - 0.004 17.6 0.2 0.73 10.3 0.0 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) SMC_N PF02463.19 ADV19375.1 - 0.005 16.3 0.0 0.48 9.8 0.0 3.1 3 1 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 ADV19375.1 - 0.0059 16.9 0.3 2.3 8.5 0.1 2.8 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 ADV19375.1 - 0.0068 16.3 0.5 1.4 8.9 0.1 2.7 2 0 0 2 2 2 1 NACHT domain AAA_17 PF13207.6 ADV19375.1 - 0.0092 16.4 0.2 5.6 7.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.12 ADV19375.1 - 0.026 14.3 0.1 1.3 8.7 0.0 2.3 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain T2SSE PF00437.20 ADV19375.1 - 0.033 13.2 0.2 2 7.4 0.0 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein cobW PF02492.19 ADV19375.1 - 0.037 13.6 1.8 3.4 7.2 0.2 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_28 PF13521.6 ADV19375.1 - 0.043 14.1 0.6 2.9 8.1 0.1 2.8 3 0 0 3 3 3 0 AAA domain Rad17 PF03215.15 ADV19375.1 - 0.061 13.2 0.0 2.1 8.2 0.0 2.3 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_19 PF13245.6 ADV19375.1 - 0.2 12.0 0.5 4 7.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 ADV19375.1 - 0.36 10.5 2.0 21 4.7 0.2 2.8 3 0 0 3 3 3 0 AAA domain ABC2_membrane_3 PF12698.7 ADV19375.1 - 0.44 9.6 56.4 0.6 9.2 23.9 3.6 2 2 0 2 2 2 0 ABC-2 family transporter protein Zn_clus PF00172.18 ADV19376.1 - 6.2e-06 26.2 10.4 6.2e-06 26.2 10.4 2.0 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 ADV19376.1 - 0.084 11.9 0.0 0.32 10.0 0.0 2.1 1 1 0 1 1 1 0 Fungal specific transcription factor domain GTP_cyclohydroI PF01227.22 ADV19377.1 - 3.1e-73 245.0 0.2 4.2e-73 244.6 0.2 1.2 1 0 0 1 1 1 1 GTP cyclohydrolase I QueF PF14489.6 ADV19377.1 - 0.011 15.9 0.0 0.044 13.9 0.0 1.9 2 0 0 2 2 2 0 QueF-like protein HATPase_c_2 PF13581.6 ADV19377.1 - 0.034 14.1 0.1 0.068 13.1 0.1 1.5 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain ERAP1_C PF11838.8 ADV19378.1 - 3.9e-76 256.6 0.0 5.5e-76 256.1 0.0 1.2 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_M1 PF01433.20 ADV19378.1 - 1.7e-73 246.8 0.0 2.5e-73 246.3 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 ADV19378.1 - 2.1e-36 125.8 0.4 1.3e-31 110.2 0.0 2.5 2 0 0 2 2 2 2 Peptidase M1 N-terminal domain Proteasome PF00227.26 ADV19380.1 - 6.7e-51 172.5 0.0 8.5e-51 172.1 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 ADV19380.1 - 1.8e-14 53.1 0.3 1.8e-14 53.1 0.3 1.8 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature CtaG_Cox11 PF04442.14 ADV19381.1 - 1.4e-56 190.8 0.0 2.1e-56 190.1 0.0 1.3 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein CtaG/Cox11 CRF PF00473.17 ADV19381.1 - 0.39 10.8 3.9 0.75 9.9 3.9 1.5 1 0 0 1 1 1 0 Corticotropin-releasing factor family LysM PF01476.20 ADV19382.1 - 0.048 13.7 0.0 0.088 12.9 0.0 1.4 1 0 0 1 1 1 0 LysM domain SRF-TF PF00319.18 ADV19383.1 - 4.3e-21 74.1 0.0 8.1e-21 73.2 0.0 1.5 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) BLOC1S3 PF15753.5 ADV19383.1 - 0.017 15.2 4.9 1.5 8.9 0.2 2.3 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex 1 subunit 3 SEEEED PF14797.6 ADV19383.1 - 4.6 7.4 17.5 0.31 11.2 11.4 2.1 2 0 0 2 2 2 0 Serine-rich region of AP3B1, clathrin-adaptor complex TFIIE-A_C PF11521.8 ADV19383.1 - 5.8 7.3 8.2 8.6 6.7 1.0 2.8 3 0 0 3 3 3 0 C-terminal general transcription factor TFIIE alpha GDA1_CD39 PF01150.17 ADV19384.1 - 2.3e-83 280.2 0.0 8.5e-83 278.4 0.0 1.7 1 1 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family LCM PF04072.14 ADV19385.1 - 8.2e-28 97.6 0.0 1.2e-27 97.1 0.0 1.3 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase DUF2838 PF10998.8 ADV19386.1 - 5.3e-43 145.8 10.2 5.3e-43 145.8 10.2 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF2838) DUF5315 PF17242.2 ADV19386.1 - 0.086 12.7 0.0 0.28 11.0 0.0 1.8 2 0 0 2 2 2 0 Disordered region of unknown function (DUF5315) Aa_trans PF01490.18 ADV19387.1 - 2.1e-72 244.1 31.4 2.6e-72 243.8 31.4 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 ADV19387.1 - 1.4e-05 24.3 17.3 1.4e-05 24.3 17.3 1.6 2 0 0 2 2 2 1 Tryptophan/tyrosine permease family Trp_oprn_chp PF09534.10 ADV19387.1 - 0.86 9.4 3.8 1.9 8.3 2.1 2.3 2 0 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) GTP_EFTU PF00009.27 ADV19388.1 - 7.7e-42 143.0 0.0 1.9e-41 141.7 0.0 1.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 ADV19388.1 - 4.4e-14 52.7 0.2 2.5e-13 50.3 0.0 2.3 3 0 0 3 3 3 1 Elongation factor Tu C-terminal domain HBS1_N PF08938.10 ADV19388.1 - 3.7e-11 43.1 0.0 9.7e-11 41.8 0.0 1.7 1 0 0 1 1 1 1 HBS1 N-terminus MMR_HSR1 PF01926.23 ADV19388.1 - 3.2e-05 24.0 0.0 0.00098 19.2 0.0 2.6 2 1 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 ADV19388.1 - 0.00021 21.6 0.1 0.00056 20.2 0.1 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.6 ADV19388.1 - 0.019 14.9 0.7 0.05 13.5 0.1 2.0 2 0 0 2 2 2 0 Elongation factor Tu domain 4 PDZ PF00595.24 ADV19388.1 - 0.09 13.1 0.0 12 6.3 0.0 2.6 2 0 0 2 2 2 0 PDZ domain S4 PF01479.25 ADV19389.1 - 1.3e-11 44.1 0.0 2.2e-11 43.3 0.0 1.4 1 0 0 1 1 1 1 S4 domain S4_2 PF13275.6 ADV19389.1 - 0.13 12.1 0.0 0.24 11.3 0.0 1.3 1 0 0 1 1 1 0 S4 domain Rhodanese PF00581.20 ADV19390.1 - 1.1e-05 25.9 0.0 1.4e-05 25.6 0.0 1.2 1 0 0 1 1 1 1 Rhodanese-like domain Aldo_ket_red PF00248.21 ADV19391.1 - 5e-44 150.7 0.0 9.5e-43 146.5 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family PEP-CTERM PF07589.11 ADV19392.1 - 5.1 7.3 7.8 11 6.3 1.2 3.1 2 0 0 2 2 2 0 PEP-CTERM motif DHHC PF01529.20 ADV19393.1 - 8.4e-26 90.7 9.3 1.8e-25 89.6 9.3 1.6 1 0 0 1 1 1 1 DHHC palmitoyltransferase PIG-P PF08510.12 ADV19393.1 - 0.26 11.2 1.7 0.59 10.1 1.7 1.5 1 0 0 1 1 1 0 PIG-P ADIP PF11559.8 ADV19395.1 - 1.4e-33 116.1 5.3 1.4e-33 116.1 5.3 3.2 2 1 1 3 3 3 1 Afadin- and alpha -actinin-Binding DivIC PF04977.15 ADV19395.1 - 0.012 15.3 0.0 0.012 15.3 0.0 4.0 4 0 0 4 4 4 0 Septum formation initiator DUF3584 PF12128.8 ADV19395.1 - 0.055 11.0 28.5 0.0085 13.7 1.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) DUF3287 PF11690.8 ADV19395.1 - 0.33 10.7 0.0 0.33 10.7 0.0 3.0 2 1 0 3 3 3 0 Protein of unknown function (DUF3287) CENP-F_leu_zip PF10473.9 ADV19395.1 - 0.52 10.3 34.3 1.2 9.2 5.0 2.7 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Fez1 PF06818.15 ADV19395.1 - 0.66 10.4 27.0 1.4 9.3 1.8 2.4 2 0 0 2 2 2 0 Fez1 AdoMetDC_leader PF08132.11 ADV19395.1 - 3.2 7.8 5.0 0.73 9.8 0.5 2.2 2 0 0 2 2 2 0 S-adenosyl-l-methionine decarboxylase leader peptide BOP1NT PF08145.12 ADV19396.1 - 1.4e-106 356.2 9.4 2.2e-106 355.5 9.4 1.3 1 0 0 1 1 1 1 BOP1NT (NUC169) domain WD40 PF00400.32 ADV19396.1 - 1.2e-26 92.4 7.7 2.9e-08 34.3 0.3 6.0 5 1 1 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV19396.1 - 1.1e-07 32.0 0.0 0.0033 17.7 0.0 4.3 2 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain DUF1682 PF07946.14 ADV19397.1 - 9.8e-65 218.9 0.0 1.1e-64 218.7 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) RRM_1 PF00076.22 ADV19398.1 - 8.3e-16 57.6 0.0 1.3e-15 57.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) F-actin_cap_A PF01267.17 ADV19399.1 - 7e-96 320.7 0.0 8.4e-96 320.5 0.0 1.1 1 0 0 1 1 1 1 F-actin capping protein alpha subunit HSP70 PF00012.20 ADV19399.1 - 0.074 11.2 5.9 0.098 10.8 5.9 1.1 1 0 0 1 1 1 0 Hsp70 protein Phlebovirus_NSM PF07246.11 ADV19400.1 - 8.9 5.6 13.3 0.11 11.9 4.8 2.0 2 0 0 2 2 2 0 Phlebovirus nonstructural protein NS-M zf-CCHC PF00098.23 ADV19401.1 - 1.5e-11 43.8 22.8 0.0085 16.1 0.5 4.3 4 0 0 4 4 4 4 Zinc knuckle zf-CCHC_3 PF13917.6 ADV19401.1 - 0.0032 17.4 13.4 0.69 9.9 0.6 4.3 2 1 2 4 4 4 3 Zinc knuckle zf-CCHC_4 PF14392.6 ADV19401.1 - 0.11 12.2 20.7 0.96 9.2 0.7 4.4 4 0 0 4 4 4 0 Zinc knuckle zf-CCHC_6 PF15288.6 ADV19401.1 - 0.34 10.8 0.1 0.34 10.8 0.1 4.0 5 0 0 5 5 5 0 Zinc knuckle zf-CCHC_2 PF13696.6 ADV19401.1 - 4.2 7.3 18.7 1.3 8.9 0.1 4.2 4 0 0 4 4 4 0 Zinc knuckle PHD_4 PF16866.5 ADV19401.1 - 7.2 6.8 10.4 3.9 7.6 0.9 3.2 2 1 1 3 3 3 0 PHD-finger MCM PF00493.23 ADV19402.1 - 7.4e-103 342.5 0.4 1.1e-102 341.8 0.4 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 ADV19402.1 - 9.7e-41 138.6 0.5 1.9e-40 137.6 0.5 1.5 1 0 0 1 1 1 1 MCM OB domain MCM6_C PF18263.1 ADV19402.1 - 5.1e-31 107.1 1.0 1.1e-30 106.1 1.0 1.6 1 0 0 1 1 1 1 MCM6 C-terminal winged-helix domain MCM_lid PF17855.1 ADV19402.1 - 5.1e-25 87.7 1.5 7.1e-25 87.2 0.4 1.9 2 0 0 2 2 1 1 MCM AAA-lid domain MCM_N PF14551.6 ADV19402.1 - 2.2e-20 73.2 0.1 8e-20 71.4 0.1 2.1 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 ADV19402.1 - 1.3e-07 31.2 0.0 1.6e-06 27.6 0.0 2.3 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 ADV19402.1 - 0.0016 18.3 0.0 0.0037 17.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 ADV19402.1 - 0.0035 17.1 0.0 0.0084 15.8 0.0 1.6 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_5 PF07728.14 ADV19402.1 - 0.012 15.6 0.0 0.028 14.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Tir_receptor_M PF03549.14 ADV19402.1 - 0.075 13.4 0.0 0.075 13.4 0.0 1.8 2 0 0 2 2 1 0 Translocated intimin receptor (Tir) intimin-binding domain ANAPC_CDC26 PF10471.9 ADV19402.1 - 0.15 12.9 4.4 0.42 11.5 4.4 1.8 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit CDC26 Peptidase_M20 PF01546.28 ADV19403.1 - 2.5e-31 109.0 0.0 3.4e-31 108.6 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 ADV19403.1 - 4.3e-14 52.4 0.0 8.4e-14 51.4 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 ADV19403.1 - 0.072 12.8 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M28 SH3BGR PF04908.15 ADV19404.1 - 6.7e-07 29.4 0.1 5.6e-06 26.4 0.0 2.2 2 0 0 2 2 2 1 SH3-binding, glutamic acid-rich protein Hydrolase_6 PF13344.6 ADV19405.1 - 5.4e-29 100.3 0.0 1.3e-28 99.1 0.0 1.7 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ADV19405.1 - 2.1e-18 66.2 0.0 3.6e-18 65.4 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 ADV19405.1 - 1.7e-11 44.9 0.0 3.4e-11 43.8 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 ADV19405.1 - 6.8e-08 32.8 0.1 0.00054 20.1 0.0 2.2 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Ribosomal_L7Ae PF01248.26 ADV19405.1 - 0.0099 15.6 0.0 0.027 14.2 0.0 1.7 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Phi29_Phage_SSB PF17427.2 ADV19405.1 - 0.014 15.6 0.0 0.025 14.7 0.0 1.4 1 0 0 1 1 1 0 Phage Single-stranded DNA-binding protein AA_permease_2 PF13520.6 ADV19406.1 - 2.9e-61 207.6 40.4 3.7e-61 207.2 40.4 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 ADV19406.1 - 2.5e-23 82.4 38.1 4.9e-23 81.5 38.1 1.3 1 1 0 1 1 1 1 Amino acid permease COPI_assoc PF08507.10 ADV19407.1 - 2e-30 105.5 6.2 2.5e-30 105.2 6.2 1.0 1 0 0 1 1 1 1 COPI associated protein Cg6151-P PF10233.9 ADV19407.1 - 1.3e-05 25.5 5.9 2.1e-05 24.8 5.9 1.3 1 1 0 1 1 1 1 Uncharacterized conserved protein CG6151-P SfLAP PF11139.8 ADV19407.1 - 0.0082 15.6 2.5 0.72 9.2 1.1 2.2 1 1 1 2 2 2 2 Sap, sulfolipid-1-addressing protein Popeye PF04831.13 ADV19407.1 - 0.14 12.3 0.1 0.25 11.5 0.1 1.4 1 0 0 1 1 1 0 Popeye protein conserved region DUF1206 PF06724.11 ADV19407.1 - 0.28 11.3 10.2 0.34 11.0 0.6 2.8 3 0 0 3 3 3 0 Domain of Unknown Function (DUF1206) DUF2065 PF09838.9 ADV19407.1 - 0.41 10.7 0.1 0.41 10.7 0.1 3.3 3 1 1 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2065) zf-met2 PF12907.7 ADV19408.1 - 2e-10 40.6 3.3 3.7e-10 39.8 3.3 1.5 1 0 0 1 1 1 1 Zinc-binding 4F5 PF04419.14 ADV19408.1 - 2.4e-06 28.3 11.7 2.4e-06 28.3 11.7 1.9 2 0 0 2 2 2 1 4F5 protein family c-SKI_SMAD_bind PF08782.10 ADV19408.1 - 0.064 13.5 0.1 0.072 13.3 0.1 1.2 1 0 0 1 1 1 0 c-SKI Smad4 binding domain zf-C2H2_12 PF18658.1 ADV19408.1 - 0.069 12.7 0.2 0.091 12.4 0.2 1.2 1 0 0 1 1 1 0 Zinc-finger C2H2-type Hydrolase_6 PF13344.6 ADV19409.1 - 6.3e-28 96.8 0.0 1e-27 96.2 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ADV19409.1 - 4.2e-18 65.2 0.0 7.5e-18 64.4 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 ADV19409.1 - 9.6e-10 39.1 0.0 3.6e-09 37.2 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 ADV19409.1 - 6e-07 29.7 1.3 1.6e-05 25.1 0.0 2.4 2 1 1 3 3 3 1 Haloacid dehalogenase-like hydrolase Nuc_sug_transp PF04142.15 ADV19409.1 - 0.19 10.9 0.0 0.26 10.4 0.0 1.1 1 0 0 1 1 1 0 Nucleotide-sugar transporter GalKase_gal_bdg PF10509.9 ADV19410.1 - 1.1e-20 73.0 0.1 1.8e-20 72.2 0.1 1.4 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_N PF00288.26 ADV19410.1 - 4.3e-13 49.3 1.0 9.1e-13 48.2 1.0 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 ADV19410.1 - 1.7e-10 41.1 0.1 1.9e-09 37.7 0.0 2.7 3 0 0 3 3 3 1 GHMP kinases C terminal WCOR413 PF05562.11 ADV19410.1 - 0.055 13.4 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 Cold acclimation protein WCOR413 DnaJ_C PF01556.18 ADV19411.1 - 1.4e-39 135.5 0.3 1.9e-39 135.1 0.3 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 ADV19411.1 - 3.1e-21 75.2 1.4 6.2e-21 74.3 1.4 1.5 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 ADV19411.1 - 1.6e-15 57.2 20.8 2.6e-15 56.5 20.8 1.3 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 ADV19411.1 - 0.05 13.6 11.0 0.1 12.6 1.8 2.5 2 0 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 ADV19411.1 - 5.6 7.0 12.8 12 6.0 4.0 2.4 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Aminotran_1_2 PF00155.21 ADV19412.1 - 5.3e-78 262.7 0.0 7.5e-78 262.2 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 ADV19412.1 - 4.5e-05 22.2 0.0 8.8e-05 21.2 0.0 1.4 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 ADV19412.1 - 9.9e-05 21.8 0.3 0.0002 20.8 0.3 1.4 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 ADV19412.1 - 0.00057 18.9 0.0 0.0013 17.7 0.0 1.6 1 1 0 1 1 1 1 Aminotransferase class-V Pertussis_S1 PF02917.14 ADV19412.1 - 0.023 14.5 0.0 0.068 12.9 0.0 1.7 1 0 0 1 1 1 0 Pertussis toxin, subunit 1 Preseq_ALAS PF09029.10 ADV19412.1 - 0.041 14.3 3.5 0.1 13.1 3.5 1.6 1 0 0 1 1 1 0 5-aminolevulinate synthase presequence DGF-1_C PF11040.8 ADV19412.1 - 0.083 12.9 0.2 0.3 11.1 0.2 1.9 1 0 0 1 1 1 0 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus STE3 PF02076.15 ADV19413.1 - 2.7e-52 177.8 17.6 3.2e-52 177.5 17.6 1.1 1 0 0 1 1 1 1 Pheromone A receptor FMN_red PF03358.15 ADV19415.1 - 3.6e-07 30.0 0.1 5.1e-07 29.5 0.1 1.4 1 1 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 ADV19415.1 - 0.00068 19.4 0.0 0.00084 19.1 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_5 PF12724.7 ADV19415.1 - 0.0013 19.0 0.0 0.018 15.3 0.0 2.0 1 1 0 2 2 2 1 Flavodoxin domain Flavodoxin_1 PF00258.25 ADV19415.1 - 0.084 13.1 0.1 2.3 8.4 0.1 2.2 1 1 0 1 1 1 0 Flavodoxin Peptidase_M13_N PF05649.13 ADV19416.1 - 1.3e-92 311.4 0.0 2.2e-92 310.7 0.0 1.4 1 1 0 1 1 1 1 Peptidase family M13 Peptidase_M13 PF01431.21 ADV19416.1 - 7.1e-60 202.1 0.0 1.9e-59 200.7 0.0 1.7 2 0 0 2 2 2 1 Peptidase family M13 IF4E PF01652.18 ADV19417.1 - 3.7e-24 85.3 0.0 6.9e-24 84.4 0.0 1.4 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E SR-25 PF10500.9 ADV19417.1 - 0.67 9.5 16.4 0.18 11.4 10.0 2.7 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Rad17 PF03215.15 ADV19418.1 - 1.3e-17 64.4 0.0 8.3e-17 61.7 0.0 2.0 1 1 0 1 1 1 1 Rad17 P-loop domain AAA PF00004.29 ADV19418.1 - 0.0031 17.9 0.0 0.0067 16.9 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ADV19418.1 - 0.006 16.9 0.0 0.014 15.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_assoc_2 PF16193.5 ADV19418.1 - 0.0063 16.8 0.0 0.02 15.2 0.0 1.8 1 0 0 1 1 1 1 AAA C-terminal domain AAA_30 PF13604.6 ADV19418.1 - 0.032 14.0 0.1 0.071 12.8 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 ADV19418.1 - 0.038 14.2 0.7 0.074 13.3 0.2 1.7 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 ADV19418.1 - 0.039 14.4 0.1 0.22 11.9 0.0 2.3 3 0 0 3 3 3 0 AAA ATPase domain TsaE PF02367.17 ADV19418.1 - 0.054 13.5 0.0 0.15 12.0 0.0 1.8 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_6 PF12774.7 ADV19418.1 - 0.096 11.6 0.0 0.16 10.9 0.0 1.2 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region AAA_18 PF13238.6 ADV19418.1 - 0.096 13.2 0.1 0.24 11.9 0.1 1.6 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 ADV19418.1 - 0.16 11.7 3.8 2.6 7.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain RuvB_N PF05496.12 ADV19418.1 - 0.18 11.6 0.0 0.35 10.6 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain BolA PF01722.18 ADV19420.1 - 2.4e-12 47.0 0.0 4.7e-12 46.0 0.0 1.5 1 1 0 1 1 1 1 BolA-like protein Adaptin_N PF01602.20 ADV19421.1 - 8.5e-125 417.3 0.3 1.1e-124 416.9 0.3 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 ADV19421.1 - 2.7e-59 199.9 0.6 1.4e-57 194.2 0.0 2.4 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 ADV19421.1 - 9e-15 54.8 7.2 6.6e-07 29.6 0.6 5.1 3 1 3 6 6 6 4 HEAT repeats HEAT PF02985.22 ADV19421.1 - 1e-07 31.6 5.4 0.0052 16.9 0.0 5.3 5 0 0 5 5 5 2 HEAT repeat Arm PF00514.23 ADV19421.1 - 1.4e-05 25.0 2.4 0.47 10.6 0.0 4.4 4 0 0 4 4 4 2 Armadillo/beta-catenin-like repeat RTP1_C1 PF10363.9 ADV19421.1 - 0.00011 22.4 1.7 0.022 14.9 0.0 3.6 4 0 0 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 Cnd3 PF12719.7 ADV19421.1 - 0.013 14.7 0.0 0.26 10.4 0.0 2.1 2 0 0 2 2 2 0 Nuclear condensing complex subunits, C-term domain RIX1 PF08167.12 ADV19421.1 - 0.042 13.6 0.0 10 5.8 0.0 2.9 3 0 0 3 3 3 0 rRNA processing/ribosome biogenesis CLASP_N PF12348.8 ADV19421.1 - 0.11 12.0 0.0 2.9 7.4 0.0 2.4 2 0 0 2 2 2 0 CLASP N terminal HEAT_EZ PF13513.6 ADV19421.1 - 1.3 9.7 8.3 0.79 10.3 0.1 4.6 5 1 1 6 6 6 0 HEAT-like repeat TPT PF03151.16 ADV19422.1 - 6.7e-18 65.0 18.7 8.2e-18 64.8 18.7 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 ADV19422.1 - 5.3e-05 23.4 35.7 0.007 16.5 9.8 2.3 2 0 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 ADV19422.1 - 0.00019 20.8 16.0 0.00043 19.6 16.0 1.7 1 1 0 1 1 1 1 UAA transporter family Porin_3 PF01459.22 ADV19423.1 - 4.6e-91 305.0 0.1 5.3e-91 304.8 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic porin WD40 PF00400.32 ADV19424.1 - 9.2e-28 95.9 30.8 0.00052 20.8 0.0 11.2 11 0 0 11 11 11 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV19424.1 - 1e-08 35.4 3.4 8.3 6.8 0.0 6.9 5 1 3 8 8 8 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ADV19424.1 - 0.0015 17.6 0.5 3 6.7 0.0 3.9 4 1 0 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Proteasome PF00227.26 ADV19425.1 - 3.2e-58 196.4 0.0 5.1e-58 195.7 0.0 1.3 2 0 0 2 2 2 1 Proteasome subunit Proteasome_A_N PF10584.9 ADV19425.1 - 4.3e-09 35.9 0.0 7.5e-09 35.1 0.0 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature THOC2_N PF16134.5 ADV19426.1 - 6.4e-141 471.1 0.0 1.4e-140 469.9 0.0 1.5 1 0 0 1 1 1 1 THO complex subunit 2 N-terminus Tho2 PF11262.8 ADV19426.1 - 7.6e-78 261.7 0.0 7.6e-78 261.7 0.0 2.3 2 0 0 2 2 2 1 Transcription factor/nuclear export subunit protein 2 Thoc2 PF11732.8 ADV19426.1 - 6.6e-21 74.2 0.0 1.8e-20 72.8 0.0 1.8 1 0 0 1 1 1 1 Transcription- and export-related complex subunit Ytp1 PF10355.9 ADV19427.1 - 4.4e-58 196.7 25.7 1.6e-56 191.6 18.3 3.1 2 1 0 2 2 2 2 Protein of unknown function (Ytp1) DUF2427 PF10348.9 ADV19427.1 - 7e-28 96.5 5.0 7e-28 96.5 5.0 2.7 2 0 0 2 2 2 1 Domain of unknown function (DUF2427) Cytochrom_B561 PF03188.16 ADV19427.1 - 1.4e-05 25.2 5.8 1.4e-05 25.2 5.8 3.6 3 2 0 3 3 3 1 Eukaryotic cytochrome b561 PPP4R2 PF09184.11 ADV19428.1 - 5e-12 46.0 0.0 6e-11 42.5 0.0 2.3 3 0 0 3 3 3 1 PPP4R2 SH2_2 PF14633.6 ADV19430.1 - 2.9e-66 223.0 0.0 2.9e-66 223.0 0.0 2.4 2 0 0 2 2 2 1 SH2 domain YqgF PF14639.6 ADV19430.1 - 1.1e-24 86.9 0.1 1.8e-11 44.0 0.0 2.6 1 1 1 2 2 2 2 Holliday-junction resolvase-like of SPT6 HHH_7 PF14635.6 ADV19430.1 - 2.9e-20 72.6 0.0 6.1e-20 71.5 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif HTH_44 PF14641.6 ADV19430.1 - 6.5e-17 62.0 0.1 2e-16 60.4 0.1 1.8 1 0 0 1 1 1 1 Helix-turn-helix DNA-binding domain of SPT6 SPT6_acidic PF14632.6 ADV19430.1 - 8.2e-15 55.2 31.5 8.2e-15 55.2 31.5 4.4 4 0 0 4 4 4 1 Acidic N-terminal SPT6 HHH_9 PF17674.1 ADV19430.1 - 5.6e-08 33.6 0.0 2.9e-07 31.3 0.0 2.4 1 0 0 1 1 1 1 HHH domain CTD PF12815.7 ADV19430.1 - 1.1e-06 29.1 4.3 3.9e-06 27.3 4.2 2.0 1 1 1 2 2 2 2 Spt5 C-terminal nonapeptide repeat binding Spt4 SH2 PF00017.24 ADV19430.1 - 3.5e-05 23.8 0.0 8.5e-05 22.6 0.0 1.7 1 0 0 1 1 1 1 SH2 domain HHH_3 PF12836.7 ADV19430.1 - 9.6e-05 22.6 0.0 0.0008 19.6 0.0 2.3 2 0 0 2 2 2 1 Helix-hairpin-helix motif Tex_YqgF PF16921.5 ADV19430.1 - 0.0022 18.4 0.0 0.0091 16.4 0.0 2.0 2 0 0 2 2 2 1 Tex protein YqgF-like domain Sua5_yciO_yrdC PF01300.18 ADV19431.1 - 6.8e-42 143.0 0.0 9.9e-42 142.5 0.0 1.3 1 0 0 1 1 1 1 Telomere recombination SUA5 PF03481.13 ADV19431.1 - 2.7e-22 79.8 0.0 4.1e-22 79.2 0.0 1.3 1 0 0 1 1 1 1 Putative GTP-binding controlling metal-binding Nop25 PF09805.9 ADV19432.1 - 8.2e-23 81.4 20.1 8.2e-23 81.4 20.1 2.1 2 0 0 2 2 2 1 Nucleolar protein 12 (25kDa) DUF572 PF04502.13 ADV19432.1 - 0.57 9.7 29.1 0.84 9.2 29.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) DNA_pol3_delta2 PF13177.6 ADV19433.1 - 3.2e-12 46.5 0.3 1.3e-11 44.5 0.3 2.0 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.29 ADV19433.1 - 3.7e-06 27.4 0.3 1.1e-05 25.8 0.3 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 ADV19433.1 - 2.5e-05 24.3 0.0 0.00029 20.8 0.0 2.2 2 0 0 2 2 2 1 Rad17 P-loop domain Rep_fac_C PF08542.11 ADV19433.1 - 0.0018 18.7 0.8 0.0062 16.9 0.0 2.2 2 0 0 2 2 2 1 Replication factor C C-terminal domain AAA_22 PF13401.6 ADV19433.1 - 0.0053 17.0 0.5 0.11 12.8 0.2 2.6 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 ADV19433.1 - 0.0071 16.7 0.0 0.028 14.8 0.0 1.9 2 1 0 2 2 2 1 AAA ATPase domain DNA_pol3_delta PF06144.13 ADV19433.1 - 0.019 14.7 0.5 0.033 14.0 0.5 1.3 1 0 0 1 1 1 0 DNA polymerase III, delta subunit DUF3802 PF12290.8 ADV19433.1 - 0.073 13.6 0.3 0.19 12.3 0.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3802) AAA_assoc_2 PF16193.5 ADV19433.1 - 0.1 13.0 0.0 0.27 11.6 0.0 1.8 1 0 0 1 1 1 0 AAA C-terminal domain AAA_33 PF13671.6 ADV19433.1 - 0.13 12.4 0.1 0.35 11.0 0.0 1.8 2 0 0 2 2 2 0 AAA domain Ribosomal_L10 PF00466.20 ADV19435.1 - 3.5e-05 23.9 0.0 0.011 15.9 0.0 2.3 2 0 0 2 2 2 2 Ribosomal protein L10 HDV_ag PF01517.18 ADV19435.1 - 0.037 13.8 0.4 0.07 12.9 0.4 1.4 1 0 0 1 1 1 0 Hepatitis delta virus delta antigen Y_phosphatase2 PF03162.13 ADV19437.1 - 1.3e-43 148.4 0.0 1.4e-43 148.3 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 ADV19437.1 - 0.013 15.5 0.0 0.027 14.4 0.0 1.6 2 0 0 2 2 2 0 Tyrosine phosphatase family RRF PF01765.19 ADV19438.1 - 1.7e-27 96.4 0.3 1.4e-26 93.4 0.0 2.1 2 0 0 2 2 2 1 Ribosome recycling factor Mt_ATP-synt_D PF05873.12 ADV19439.1 - 1.9e-15 57.0 0.3 2.4e-15 56.7 0.3 1.1 1 0 0 1 1 1 1 ATP synthase D chain, mitochondrial (ATP5H) DUF5627 PF18620.1 ADV19439.1 - 0.059 13.2 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5627) Spc7 PF08317.11 ADV19439.1 - 0.11 11.4 0.5 0.18 10.6 0.1 1.5 2 0 0 2 2 2 0 Spc7 kinetochore protein NmrA PF05368.13 ADV19440.1 - 4.7e-42 144.1 0.0 6.1e-42 143.8 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 ADV19440.1 - 6.7e-09 35.9 0.0 1e-08 35.3 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 ADV19440.1 - 0.00091 18.7 0.0 0.0012 18.3 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family IlvN PF07991.12 ADV19440.1 - 0.001 18.7 0.4 0.0028 17.2 0.1 1.8 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain TrkA_N PF02254.18 ADV19440.1 - 0.001 19.3 0.0 0.0019 18.4 0.0 1.4 1 0 0 1 1 1 1 TrkA-N domain PK_C PF02887.16 ADV19440.1 - 0.0042 17.3 0.1 0.029 14.6 0.1 2.1 1 1 1 2 2 2 1 Pyruvate kinase, alpha/beta domain UPF0180 PF03698.13 ADV19440.1 - 0.0081 16.3 0.1 2.7 8.2 0.0 2.8 2 1 1 3 3 3 2 Uncharacterised protein family (UPF0180) F420_oxidored PF03807.17 ADV19440.1 - 0.02 15.5 0.0 0.048 14.3 0.0 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent LytR_C PF13399.6 ADV19440.1 - 0.19 12.7 1.5 31 5.6 0.2 2.7 2 1 1 3 3 3 0 LytR cell envelope-related transcriptional attenuator bZIP_2 PF07716.15 ADV19441.1 - 6.6e-06 26.1 11.8 6.6e-06 26.1 11.8 2.7 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_1 PF00170.21 ADV19441.1 - 2.7e-05 24.2 9.6 2.7e-05 24.2 9.6 2.2 2 0 0 2 2 2 1 bZIP transcription factor bZIP_Maf PF03131.17 ADV19441.1 - 0.0068 16.9 6.1 0.0068 16.9 6.1 2.7 2 0 0 2 2 2 1 bZIP Maf transcription factor AAR2 PF05282.11 ADV19441.1 - 0.0078 15.7 1.9 0.018 14.5 1.9 1.5 1 0 0 1 1 1 1 AAR2 protein MCM_bind PF09739.9 ADV19441.1 - 0.055 11.9 4.2 0.1 11.0 4.2 1.4 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Gti1_Pac2 PF09729.9 ADV19441.1 - 0.77 9.8 4.5 0.43 10.6 0.9 2.0 2 0 0 2 2 2 0 Gti1/Pac2 family NPR3 PF03666.13 ADV19441.1 - 3.6 6.3 8.1 7 5.3 8.1 1.4 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 RNA_polI_A34 PF08208.11 ADV19441.1 - 4.5 7.3 18.4 0.72 9.9 11.7 2.3 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 CDC27 PF09507.10 ADV19441.1 - 4.7 6.5 31.4 0.1 11.9 23.7 1.8 1 1 0 1 1 1 0 DNA polymerase subunit Cdc27 Rad60-SLD_2 PF13881.6 ADV19442.1 - 0.0026 17.8 0.0 0.0054 16.8 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ATP_bind_1 PF03029.17 ADV19443.1 - 1.1e-82 277.5 0.0 1.2e-82 277.3 0.0 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.27 ADV19443.1 - 2.2e-05 24.1 0.1 0.00074 19.1 0.1 2.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain CLP1_P PF16575.5 ADV19443.1 - 5.9e-05 22.9 0.0 0.0014 18.4 0.0 2.3 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop Gtr1_RagA PF04670.12 ADV19443.1 - 0.00031 20.2 0.0 0.0032 16.9 0.0 2.2 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region AAA_24 PF13479.6 ADV19443.1 - 0.0012 18.6 0.0 0.0018 18.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain CbiA PF01656.23 ADV19443.1 - 0.0017 18.4 0.0 0.0041 17.2 0.0 1.8 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MeaB PF03308.16 ADV19443.1 - 0.0021 17.1 0.0 0.0035 16.4 0.0 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_30 PF13604.6 ADV19443.1 - 0.0038 17.0 0.0 0.0068 16.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ADV19443.1 - 0.0093 16.5 0.0 0.02 15.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 ADV19443.1 - 0.0094 16.2 0.0 0.025 14.9 0.0 1.8 2 0 0 2 2 1 1 AAA domain RsgA_GTPase PF03193.16 ADV19443.1 - 0.0096 15.8 0.2 1.5 8.7 0.0 2.9 3 1 0 3 3 3 1 RsgA GTPase SRP54 PF00448.22 ADV19443.1 - 0.013 15.2 0.0 0.025 14.2 0.0 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain T2SSE PF00437.20 ADV19443.1 - 0.013 14.6 0.0 0.022 13.8 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein ArsA_ATPase PF02374.15 ADV19443.1 - 0.014 14.6 0.0 0.025 13.8 0.0 1.5 1 0 0 1 1 1 0 Anion-transporting ATPase cobW PF02492.19 ADV19443.1 - 0.015 14.9 0.1 0.14 11.8 0.1 2.3 1 1 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_14 PF13173.6 ADV19443.1 - 0.016 15.2 0.0 0.035 14.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 ADV19443.1 - 0.018 15.1 0.0 0.063 13.4 0.0 2.2 1 1 0 1 1 1 0 50S ribosome-binding GTPase ATPase PF06745.13 ADV19443.1 - 0.018 14.4 0.0 0.03 13.7 0.0 1.4 1 0 0 1 1 1 0 KaiC AAA_16 PF13191.6 ADV19443.1 - 0.021 15.2 0.0 0.041 14.3 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_31 PF13614.6 ADV19443.1 - 0.023 14.6 0.3 3.8 7.4 0.2 2.4 1 1 1 2 2 2 0 AAA domain AAA_29 PF13555.6 ADV19443.1 - 0.031 14.0 0.0 0.057 13.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain RNA_helicase PF00910.22 ADV19443.1 - 0.034 14.5 0.0 0.1 13.0 0.0 1.8 2 0 0 2 2 1 0 RNA helicase NTPase_1 PF03266.15 ADV19443.1 - 0.035 14.0 0.3 0.085 12.8 0.1 1.8 2 0 0 2 2 2 0 NTPase ABC_tran PF00005.27 ADV19443.1 - 0.036 14.6 0.0 0.086 13.4 0.0 1.6 1 0 0 1 1 1 0 ABC transporter AAA_33 PF13671.6 ADV19443.1 - 0.038 14.1 0.0 0.069 13.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain DUF463 PF04317.12 ADV19443.1 - 0.073 12.0 0.0 0.13 11.1 0.0 1.3 1 0 0 1 1 1 0 YcjX-like family, DUF463 NACHT PF05729.12 ADV19443.1 - 0.074 13.0 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 NACHT domain IstB_IS21 PF01695.17 ADV19443.1 - 0.11 12.2 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA PF00004.29 ADV19443.1 - 0.12 12.8 0.0 0.32 11.4 0.0 1.7 2 0 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) MipZ PF09140.11 ADV19443.1 - 0.13 11.5 0.1 0.97 8.7 0.1 2.2 1 1 0 1 1 1 0 ATPase MipZ AAA_25 PF13481.6 ADV19443.1 - 0.14 11.7 0.1 0.46 10.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain KAP_NTPase PF07693.14 ADV19443.1 - 0.15 11.3 0.0 0.48 9.6 0.0 1.7 2 0 0 2 2 2 0 KAP family P-loop domain Glutaredoxin PF00462.24 ADV19444.1 - 5.7e-17 61.7 0.1 8.7e-17 61.1 0.1 1.3 1 0 0 1 1 1 1 Glutaredoxin SPA PF08616.10 ADV19445.1 - 5.6e-35 119.7 0.0 1.1e-34 118.8 0.0 1.5 1 0 0 1 1 1 1 Stabilization of polarity axis Afi1 PF07792.12 ADV19445.1 - 2.5e-21 76.6 0.0 1.1e-20 74.5 0.0 2.0 1 1 0 1 1 1 1 Docking domain of Afi1 for Arf3 in vesicle trafficking Avl9 PF09794.9 ADV19445.1 - 7.2e-07 28.2 0.0 0.043 12.5 0.0 3.4 2 1 1 3 3 3 2 Transport protein Avl9 Big_1 PF02369.16 ADV19445.1 - 0.16 12.0 0.9 0.45 10.6 0.9 1.7 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 1) GTP_EFTU PF00009.27 ADV19447.1 - 1.2e-17 64.1 0.0 3.2e-17 62.7 0.0 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 ADV19447.1 - 1.4e-08 35.0 2.4 2.6e-08 34.1 0.4 2.6 3 0 0 3 3 3 1 Elongation factor Tu domain 2 GTP_EFTU_D3 PF03143.17 ADV19447.1 - 4e-05 23.9 0.7 0.00012 22.3 0.1 2.1 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain MMR_HSR1 PF01926.23 ADV19447.1 - 0.1 12.7 0.1 0.3 11.2 0.1 1.9 1 1 0 1 1 1 0 50S ribosome-binding GTPase EB1 PF03271.17 ADV19448.1 - 4.3e-14 52.5 0.5 8.2e-14 51.6 0.5 1.5 1 0 0 1 1 1 1 EB1-like C-terminal motif CH PF00307.31 ADV19448.1 - 1.1e-06 28.8 0.1 9.6e-06 25.7 0.0 2.1 2 0 0 2 2 2 1 Calponin homology (CH) domain FUN14 PF04930.15 ADV19449.1 - 4.6e-12 46.2 0.3 8e-12 45.4 0.3 1.4 1 0 0 1 1 1 1 FUN14 family Rab5ip PF07019.12 ADV19449.1 - 0.14 12.8 1.3 0.57 10.8 0.7 2.1 2 0 0 2 2 2 0 Rab5-interacting protein (Rab5ip) BAR PF03114.18 ADV19451.1 - 1.4e-41 142.8 0.2 1.7e-41 142.5 0.2 1.1 1 0 0 1 1 1 1 BAR domain Arfaptin PF06456.13 ADV19451.1 - 0.019 14.5 1.8 0.16 11.5 1.8 2.1 1 1 0 1 1 1 0 Arfaptin-like domain Sec34 PF04136.15 ADV19451.1 - 0.092 12.6 0.2 0.28 11.0 0.1 1.8 2 0 0 2 2 2 0 Sec34-like family PUF PF00806.19 ADV19452.1 - 9.7e-52 169.9 0.6 4.4e-08 32.4 0.0 7.6 7 0 0 7 7 7 7 Pumilio-family RNA binding repeat TBPIP PF07106.13 ADV19452.1 - 0.033 14.1 0.0 2.3 8.2 0.0 3.0 2 0 0 2 2 2 0 TBPIP/Hop2 winged helix domain Ribosomal_S3Ae PF01015.18 ADV19453.1 - 1.9e-92 308.4 2.4 2.3e-92 308.1 2.4 1.0 1 0 0 1 1 1 1 Ribosomal S3Ae family Abhydro_lipase PF04083.16 ADV19453.1 - 0.0098 15.4 0.0 0.019 14.5 0.0 1.5 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Wtap PF17098.5 ADV19453.1 - 0.073 13.0 1.0 0.17 11.8 0.1 1.9 2 0 0 2 2 2 0 WTAP/Mum2p family RRM_1 PF00076.22 ADV19454.1 - 4e-31 106.7 0.8 2.9e-11 43.0 0.0 4.4 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ADV19454.1 - 4.7e-06 26.2 0.0 0.65 9.6 0.0 3.5 2 1 1 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ADV19454.1 - 5e-05 23.1 0.0 13 5.7 0.0 4.3 4 0 0 4 4 4 1 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 ADV19454.1 - 0.00015 21.7 0.0 0.089 12.8 0.0 3.6 4 0 0 4 4 4 1 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 ADV19454.1 - 0.00097 19.1 0.0 0.43 10.6 0.0 2.5 2 0 0 2 2 2 2 RNA binding motif DUF4523 PF15023.6 ADV19454.1 - 0.001 19.0 0.0 3.3 7.5 0.0 3.2 2 1 1 3 3 3 1 Protein of unknown function (DUF4523) RL PF17797.1 ADV19454.1 - 0.0055 16.6 0.0 0.8 9.7 0.0 2.5 2 0 0 2 2 2 1 RL domain DUF1866 PF08952.11 ADV19454.1 - 0.0081 16.0 0.0 12 5.7 0.0 3.8 3 1 1 4 4 4 1 Domain of unknown function (DUF1866) RRM_7 PF16367.5 ADV19454.1 - 0.052 13.7 0.0 6.5 6.9 0.0 3.6 4 1 1 5 5 5 0 RNA recognition motif DM PF00751.18 ADV19455.1 - 0.3 11.0 3.3 0.75 9.8 0.6 2.5 2 0 0 2 2 2 0 DM DNA binding domain Ribosomal_L37ae PF01780.19 ADV19456.1 - 1.6e-39 133.9 8.6 1.8e-39 133.7 8.6 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family Zn_Tnp_IS1595 PF12760.7 ADV19456.1 - 0.001 19.0 1.6 0.0014 18.5 1.6 1.3 1 0 0 1 1 1 1 Transposase zinc-ribbon domain Rep_fac-A_C PF08646.10 ADV19456.1 - 0.0023 17.7 0.9 0.0032 17.2 0.9 1.2 1 0 0 1 1 1 1 Replication factor-A C terminal domain A2L_zn_ribbon PF08792.10 ADV19456.1 - 0.0092 15.7 1.6 0.37 10.6 0.0 2.1 2 0 0 2 2 2 1 A2L zinc ribbon domain zf-C2H2 PF00096.26 ADV19456.1 - 0.018 15.5 1.5 3.6 8.2 0.1 2.5 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ADV19456.1 - 0.032 14.7 2.4 1.5 9.4 0.3 2.4 1 1 1 2 2 2 0 Zinc-finger double domain ADK_lid PF05191.14 ADV19456.1 - 0.063 13.3 2.8 6.5 6.8 0.3 2.2 2 0 0 2 2 2 0 Adenylate kinase, active site lid Zn-ribbon_8 PF09723.10 ADV19456.1 - 0.067 13.3 1.1 0.25 11.5 0.1 2.0 2 0 0 2 2 2 0 Zinc ribbon domain Elf1 PF05129.13 ADV19456.1 - 0.08 13.0 1.3 0.12 12.4 1.3 1.5 1 1 0 1 1 1 0 Transcription elongation factor Elf1 like zf-HIT PF04438.16 ADV19456.1 - 0.084 12.8 2.8 0.23 11.4 0.4 2.2 2 0 0 2 2 2 0 HIT zinc finger OrfB_Zn_ribbon PF07282.11 ADV19456.1 - 0.086 12.8 2.1 0.13 12.2 2.0 1.4 1 1 0 1 1 1 0 Putative transposase DNA-binding domain zf_Rg PF17915.1 ADV19456.1 - 0.11 11.9 0.6 0.16 11.4 0.6 1.2 1 0 0 1 1 1 0 Reverse gyrase zinc finger zf-IS66 PF13005.7 ADV19456.1 - 0.32 11.4 3.7 8.9 6.8 0.8 2.5 1 1 1 2 2 2 0 zinc-finger binding domain of transposase IS66 Zn_ribbon_SprT PF17283.2 ADV19456.1 - 4.9 7.1 8.6 1 9.3 3.9 2.2 2 1 0 2 2 2 0 SprT-like zinc ribbon domain Complex1_LYR_2 PF13233.6 ADV19457.1 - 2.1e-16 60.5 0.0 2.7e-16 60.1 0.0 1.3 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.15 ADV19457.1 - 2.3e-07 30.7 0.0 5e-07 29.7 0.0 1.6 2 0 0 2 2 2 1 Complex 1 protein (LYR family) SOG2 PF10428.9 ADV19458.1 - 6.9e-114 381.8 3.7 6.9e-114 381.8 3.7 4.1 4 0 0 4 4 4 1 RAM signalling pathway protein LRR_8 PF13855.6 ADV19458.1 - 2.8e-10 39.8 2.6 1.1e-06 28.2 0.3 2.7 1 1 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 ADV19458.1 - 1.2e-08 35.1 2.4 1.4e-05 25.3 0.8 2.6 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 ADV19458.1 - 0.00089 18.8 0.2 0.0021 17.6 0.2 1.6 1 1 0 1 1 1 1 Leucine-rich repeat LRR_1 PF00560.33 ADV19458.1 - 0.0083 16.5 0.5 19 6.3 0.0 4.4 4 0 0 4 4 4 1 Leucine Rich Repeat LRR_6 PF13516.6 ADV19458.1 - 0.056 13.5 1.2 25 5.3 0.1 3.4 3 0 0 3 3 3 0 Leucine Rich repeat PGI PF00342.19 ADV19459.1 - 3.4e-234 777.9 0.8 4.2e-234 777.6 0.8 1.1 1 0 0 1 1 1 1 Phosphoglucose isomerase Zn_clus PF00172.18 ADV19460.1 - 5.7e-06 26.4 6.3 9.4e-06 25.7 6.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-AN1 PF01428.16 ADV19461.1 - 1e-17 64.0 32.2 6.2e-10 39.1 10.2 2.8 3 0 0 3 3 3 2 AN1-like Zinc finger SHOCT PF09851.9 ADV19461.1 - 0.082 12.7 2.7 0.23 11.2 0.1 2.3 2 0 0 2 2 2 0 Short C-terminal domain Sugar_tr PF00083.24 ADV19462.1 - 3.6e-93 312.9 21.7 4.4e-93 312.6 21.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ADV19462.1 - 1.2e-19 70.5 56.2 1.7e-17 63.4 29.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily WD40 PF00400.32 ADV19463.1 - 1.3e-33 114.5 24.9 3.5e-08 34.0 2.2 7.7 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV19463.1 - 5.3e-10 39.5 0.5 0.17 12.2 0.0 5.2 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ADV19463.1 - 5.1e-06 25.4 0.1 0.0044 15.7 0.0 2.6 2 1 1 3 3 3 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ADV19463.1 - 0.0067 15.4 0.0 0.54 9.2 0.0 2.8 2 1 1 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein VID27 PF08553.10 ADV19463.1 - 0.064 12.3 0.1 0.13 11.2 0.0 1.5 2 0 0 2 2 2 0 VID27 C-terminal WD40-like domain WD40_like PF17005.5 ADV19463.1 - 0.13 11.5 1.3 2.8 7.2 0.0 3.0 3 1 0 3 3 3 0 WD40-like domain LIM PF00412.22 ADV19464.1 - 5.5e-15 55.3 21.2 1.4e-10 41.3 3.8 4.4 4 1 0 4 4 4 3 LIM domain TFIIA PF03153.13 ADV19464.1 - 6 6.8 9.9 9.7 6.1 9.9 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit BRCT_2 PF16589.5 ADV19465.1 - 1.6e-13 50.9 0.0 3.4e-13 49.8 0.0 1.6 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 ADV19465.1 - 1.8e-09 37.8 0.1 5.3e-09 36.3 0.1 1.8 1 1 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 ADV19465.1 - 5.2e-05 23.5 0.0 0.00011 22.4 0.0 1.5 1 0 0 1 1 1 1 DNA ligase 3 BRCT domain PTCB-BRCT PF12738.7 ADV19465.1 - 0.00024 21.0 1.3 0.0016 18.4 1.3 2.3 1 1 0 1 1 1 1 twin BRCT domain NAD_Gly3P_dh_C PF07479.14 ADV19465.1 - 0.15 12.4 0.1 0.2 11.9 0.1 1.3 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus AAA PF00004.29 ADV19466.1 - 1.7e-45 154.7 0.0 3.9e-45 153.5 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 ADV19466.1 - 4.2e-12 45.8 0.3 2.4e-11 43.4 0.1 2.3 2 0 0 2 2 2 1 Proteasomal ATPase OB C-terminal domain AAA_5 PF07728.14 ADV19466.1 - 9.9e-09 35.3 0.1 4.1e-08 33.3 0.1 2.0 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ADV19466.1 - 2.3e-08 34.6 0.4 1.8e-05 25.2 0.0 3.2 1 1 1 3 3 3 1 AAA ATPase domain AAA_2 PF07724.14 ADV19466.1 - 2.2e-07 31.2 0.0 4.1e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 ADV19466.1 - 3.2e-07 29.8 0.0 6.1e-07 28.9 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_22 PF13401.6 ADV19466.1 - 5.1e-05 23.6 3.5 0.0093 16.2 0.0 3.6 2 1 2 4 4 4 1 AAA domain AAA_lid_3 PF17862.1 ADV19466.1 - 0.00017 21.4 0.0 0.00037 20.2 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain NTPase_1 PF03266.15 ADV19466.1 - 0.00021 21.2 0.2 0.0013 18.7 0.0 2.2 3 0 0 3 3 3 1 NTPase AAA_30 PF13604.6 ADV19466.1 - 0.00025 20.8 0.0 0.00049 19.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 ADV19466.1 - 0.00045 19.8 0.1 0.0041 16.6 0.1 2.1 1 1 0 1 1 1 1 P-loop containing dynein motor region RuvB_N PF05496.12 ADV19466.1 - 0.00046 20.0 0.0 0.0015 18.3 0.0 1.8 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 ADV19466.1 - 0.00048 20.4 0.5 0.0021 18.3 0.0 2.2 3 0 0 3 3 2 1 AAA domain AAA_18 PF13238.6 ADV19466.1 - 0.00055 20.5 0.0 0.0081 16.7 0.0 2.6 3 0 0 3 3 3 1 AAA domain TIP49 PF06068.13 ADV19466.1 - 0.00058 19.2 0.0 0.001 18.4 0.0 1.5 1 1 0 1 1 1 1 TIP49 P-loop domain TsaE PF02367.17 ADV19466.1 - 0.0017 18.3 0.0 0.003 17.6 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 ADV19466.1 - 0.0033 17.6 0.2 0.016 15.4 0.0 2.2 2 1 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 ADV19466.1 - 0.0045 17.4 0.0 0.0099 16.3 0.0 1.6 1 0 0 1 1 1 1 RNA helicase Mg_chelatase PF01078.21 ADV19466.1 - 0.0061 16.0 0.2 0.018 14.5 0.1 1.8 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 ADV19466.1 - 0.009 15.9 0.0 0.02 14.7 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 ADV19466.1 - 0.0098 15.8 0.1 0.22 11.4 0.0 2.5 1 1 0 2 2 2 1 ATPase domain predominantly from Archaea AAA_24 PF13479.6 ADV19466.1 - 0.013 15.2 0.1 0.024 14.4 0.1 1.5 1 1 0 1 1 1 0 AAA domain TniB PF05621.11 ADV19466.1 - 0.014 14.8 0.0 0.32 10.4 0.0 2.3 2 0 0 2 2 2 0 Bacterial TniB protein NACHT PF05729.12 ADV19466.1 - 0.014 15.3 0.1 0.054 13.4 0.0 2.0 2 0 0 2 2 2 0 NACHT domain AAA_14 PF13173.6 ADV19466.1 - 0.018 15.1 0.0 0.063 13.3 0.0 1.9 3 0 0 3 3 1 0 AAA domain AAA_11 PF13086.6 ADV19466.1 - 0.019 14.8 0.0 0.059 13.2 0.0 1.8 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 ADV19466.1 - 0.021 14.6 0.0 0.051 13.3 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein Sigma54_activat PF00158.26 ADV19466.1 - 0.023 14.4 0.2 1.2 8.8 0.0 3.0 3 1 1 4 4 3 0 Sigma-54 interaction domain AFG1_ATPase PF03969.16 ADV19466.1 - 0.03 13.2 0.0 0.053 12.4 0.0 1.5 1 0 0 1 1 1 0 AFG1-like ATPase cobW PF02492.19 ADV19466.1 - 0.052 13.1 0.0 0.092 12.3 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Parvo_NS1 PF01057.17 ADV19466.1 - 0.075 12.1 0.0 0.13 11.3 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 ABC_tran PF00005.27 ADV19466.1 - 0.091 13.3 0.0 0.37 11.3 0.0 2.1 1 1 0 1 1 1 0 ABC transporter AAA_19 PF13245.6 ADV19466.1 - 0.091 13.1 0.1 0.31 11.4 0.1 1.8 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 ADV19466.1 - 0.11 12.1 0.4 0.44 10.1 0.1 2.0 1 1 0 2 2 2 0 AAA domain Bac_DnaA PF00308.18 ADV19466.1 - 0.12 12.2 0.0 0.25 11.1 0.0 1.6 1 1 0 1 1 1 0 Bacterial dnaA protein RCC1 PF00415.18 ADV19467.1 - 3.3e-17 62.8 1.0 0.0084 16.7 0.0 5.7 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.31 ADV19467.1 - 2.9e-14 53.2 0.0 6.4e-08 32.8 0.0 3.2 2 1 0 2 2 2 2 BTB/POZ domain Ank_2 PF12796.7 ADV19467.1 - 2.8e-07 31.0 0.0 8e-07 29.6 0.0 1.8 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) RCC1_2 PF13540.6 ADV19467.1 - 8.5e-07 28.6 0.2 8.5e-07 28.6 0.2 5.0 5 0 0 5 5 5 1 Regulator of chromosome condensation (RCC1) repeat Ank_4 PF13637.6 ADV19467.1 - 1.3e-05 25.6 0.5 0.022 15.4 0.0 3.1 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 ADV19467.1 - 9.8e-05 22.6 0.1 0.068 13.5 0.1 2.7 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 ADV19467.1 - 0.0034 17.8 0.2 1.3 9.6 0.0 2.9 2 0 0 2 2 2 1 Ankyrin repeat Ank_3 PF13606.6 ADV19467.1 - 0.0038 17.6 0.1 4.3 8.2 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat PAS PF00989.25 ADV19468.1 - 0.0032 17.5 3.4 0.011 15.8 0.0 3.0 3 0 0 3 3 3 1 PAS fold Zn_clus PF00172.18 ADV19468.1 - 0.0038 17.3 11.3 0.0071 16.4 11.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SUIM_assoc PF16619.5 ADV19468.1 - 0.32 11.1 20.1 0.29 11.2 7.5 2.9 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 DUF4407 PF14362.6 ADV19468.1 - 4.2 6.6 5.3 6.9 5.9 5.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Presenilin PF01080.17 ADV19468.1 - 4.4 6.0 9.6 7.1 5.3 9.6 1.3 1 0 0 1 1 1 0 Presenilin F_actin_cap_B PF01115.17 ADV19469.1 - 7.3e-98 326.9 0.0 8.4e-98 326.7 0.0 1.0 1 0 0 1 1 1 1 F-actin capping protein, beta subunit PAPS_reduct PF01507.19 ADV19470.1 - 5.6e-41 140.5 0.0 7.6e-41 140.0 0.0 1.2 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family Cpn60_TCP1 PF00118.24 ADV19472.1 - 3.7e-86 289.7 9.7 6.8e-86 288.8 9.7 1.4 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family FIST PF08495.10 ADV19472.1 - 0.17 11.9 1.3 5.7 6.9 0.2 3.0 2 2 1 3 3 3 0 FIST N domain SET PF00856.28 ADV19473.1 - 6.5e-09 36.4 0.0 1.2e-08 35.5 0.0 1.5 1 1 0 1 1 1 1 SET domain zf-MYND PF01753.18 ADV19473.1 - 1.4 9.1 9.4 0.045 13.8 3.2 1.7 2 0 0 2 2 2 0 MYND finger NFACT-R_1 PF05670.13 ADV19474.1 - 7.3e-39 132.8 0.0 1.2e-38 132.1 0.0 1.3 1 0 0 1 1 1 1 NFACT protein RNA binding domain RsgI_N PF12791.7 ADV19474.1 - 0.045 13.7 0.1 0.12 12.3 0.1 1.8 1 0 0 1 1 1 0 Anti-sigma factor N-terminus Selenoprotein_S PF06936.11 ADV19474.1 - 3.4 7.4 11.0 4.9 6.9 11.0 1.2 1 0 0 1 1 1 0 Selenoprotein S (SelS) Lactonase PF10282.9 ADV19475.1 - 1.3e-47 162.8 0.0 1.4e-47 162.6 0.0 1.1 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller DUF2415 PF10313.9 ADV19476.1 - 9.2e-16 57.5 0.0 2.3e-15 56.3 0.0 1.7 1 0 0 1 1 1 1 Uncharacterised protein domain (DUF2415) WD40 PF00400.32 ADV19476.1 - 3.4e-05 24.5 1.8 0.78 10.7 0.1 4.2 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV19476.1 - 0.0033 17.7 0.0 0.22 11.8 0.0 3.1 4 0 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ADV19476.1 - 0.067 12.2 0.0 6.7 5.6 0.0 2.3 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 ADV19476.1 - 0.14 10.6 0.5 0.91 8.0 0.3 2.2 2 1 0 2 2 2 0 Cytochrome D1 heme domain RCC1_2 PF13540.6 ADV19477.1 - 7.3e-21 73.4 17.4 1.9e-08 33.9 0.1 6.0 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 ADV19477.1 - 3.9e-17 62.6 8.2 1.7e-07 31.7 0.5 7.2 7 1 0 7 7 7 3 Regulator of chromosome condensation (RCC1) repeat F-box PF00646.33 ADV19477.1 - 3.7e-05 23.5 0.1 6.5e-05 22.7 0.1 1.4 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 ADV19477.1 - 9.9e-05 22.2 0.3 0.00024 20.9 0.3 1.7 1 0 0 1 1 1 1 F-box-like Adap_comp_sub PF00928.21 ADV19478.1 - 2e-52 178.2 0.0 2.4e-52 177.9 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 ADV19478.1 - 6.8e-07 29.3 0.1 1.4e-06 28.3 0.1 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Ras PF00071.22 ADV19479.1 - 7.4e-44 149.2 0.0 8.5e-44 149.0 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ADV19479.1 - 6.9e-12 45.6 0.0 9.5e-12 45.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ADV19479.1 - 1.2e-06 28.1 0.0 1.4e-06 27.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ADV19479.1 - 1.5e-05 25.1 0.0 2.6e-05 24.3 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ADV19479.1 - 0.00022 21.2 0.2 0.31 10.9 0.0 2.2 1 1 1 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 ADV19479.1 - 0.0019 17.8 0.2 0.16 11.5 0.0 2.2 1 1 0 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 ADV19479.1 - 0.0072 15.9 0.0 0.11 12.0 0.0 2.0 2 0 0 2 2 2 1 Ferrous iron transport protein B PduV-EutP PF10662.9 ADV19479.1 - 0.027 14.2 0.0 0.057 13.2 0.0 1.6 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_28 PF13521.6 ADV19479.1 - 0.034 14.4 0.0 0.066 13.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain SRPRB PF09439.10 ADV19479.1 - 0.062 12.7 0.0 0.09 12.2 0.0 1.3 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit GalP_UDP_transf PF01087.22 ADV19480.1 - 3.8e-62 210.0 0.0 5.1e-62 209.6 0.0 1.2 1 0 0 1 1 1 1 Galactose-1-phosphate uridyl transferase, N-terminal domain GalP_UDP_tr_C PF02744.17 ADV19480.1 - 5e-53 179.2 0.0 8.6e-53 178.5 0.0 1.3 1 0 0 1 1 1 1 Galactose-1-phosphate uridyl transferase, C-terminal domain DUF4921 PF16268.5 ADV19480.1 - 0.0028 16.5 0.0 0.39 9.5 0.1 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF4921) RPEL PF02755.15 ADV19481.1 - 8.8e-10 38.0 1.7 3.9e-07 29.6 0.2 2.4 2 0 0 2 2 2 2 RPEL repeat UCH PF00443.29 ADV19482.1 - 4e-35 121.5 0.0 1e-34 120.2 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ADV19482.1 - 1.2e-07 31.7 0.9 0.00015 21.4 0.0 3.2 3 0 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase GEN1_C PF18380.1 ADV19482.1 - 0.086 13.7 3.9 5.6 7.9 0.2 2.9 2 0 0 2 2 2 0 Holliday junction resolvase Gen1 C-terminal domain BUD22 PF09073.10 ADV19482.1 - 0.15 11.4 7.2 0.22 10.8 4.5 2.2 2 0 0 2 2 2 0 BUD22 DUF4834 PF16118.5 ADV19482.1 - 0.19 12.7 1.2 0.88 10.6 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) UPF0029 PF01205.19 ADV19483.1 - 8.9e-16 58.1 0.0 1.6e-15 57.3 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 Hep_59 PF07052.11 ADV19484.1 - 4.8e-30 104.4 4.4 4.8e-30 104.4 4.4 3.5 3 1 0 3 3 3 1 Hepatocellular carcinoma-associated antigen 59 Aa_trans PF01490.18 ADV19485.1 - 1.5e-50 172.1 12.0 1.8e-50 171.9 12.0 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 ADV19485.1 - 9.3e-05 21.6 7.4 9.3e-05 21.6 7.4 1.7 2 0 0 2 2 2 1 Tryptophan/tyrosine permease family LAMTOR PF15454.6 ADV19485.1 - 0.19 12.4 0.3 0.55 10.9 0.1 1.8 2 0 0 2 2 2 0 Late endosomal/lysosomal adaptor and MAPK and MTOR activator Arv1 PF04161.13 ADV19485.1 - 0.9 9.7 4.9 0.8 9.8 0.1 2.5 2 1 0 2 2 2 0 Arv1-like family Cofilin_ADF PF00241.20 ADV19486.1 - 8.9e-26 90.1 0.0 3e-10 39.9 0.0 3.1 3 0 0 3 3 3 3 Cofilin/tropomyosin-type actin-binding protein SPDY PF03771.16 ADV19486.1 - 0.6 10.1 3.7 0.88 9.6 0.3 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF317) Methyltransf_25 PF13649.6 ADV19487.1 - 8.7e-11 42.4 0.1 3.7e-10 40.4 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.13 ADV19487.1 - 1.2e-09 38.0 0.0 1.7e-09 37.5 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_11 PF08241.12 ADV19487.1 - 1.6e-08 35.1 0.0 6.2e-08 33.2 0.0 2.0 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 ADV19487.1 - 1.8e-08 34.3 0.1 5.2e-08 32.8 0.1 1.7 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 ADV19487.1 - 4.6e-07 29.8 0.0 1.3e-06 28.3 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 ADV19487.1 - 8.4e-07 28.2 0.0 1.2e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_12 PF08242.12 ADV19487.1 - 5.6e-06 27.0 0.0 1.2e-05 26.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ADV19487.1 - 0.00034 20.2 0.1 0.0006 19.4 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_18 PF12847.7 ADV19487.1 - 0.00055 19.9 0.0 0.0009 19.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 ADV19487.1 - 0.00066 19.1 0.0 0.00087 18.7 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase PCMT PF01135.19 ADV19487.1 - 0.002 17.9 0.0 0.0035 17.1 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) FtsJ PF01728.19 ADV19487.1 - 0.012 15.7 0.0 0.019 15.1 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase Ubie_methyltran PF01209.18 ADV19487.1 - 0.013 14.9 0.0 0.018 14.4 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_16 PF10294.9 ADV19487.1 - 0.055 13.2 0.1 0.084 12.6 0.1 1.2 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_32 PF13679.6 ADV19487.1 - 0.075 13.0 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain TehB PF03848.14 ADV19487.1 - 0.11 11.9 1.0 0.52 9.7 0.3 2.4 2 1 0 2 2 2 0 Tellurite resistance protein TehB Methyltransf_4 PF02390.17 ADV19487.1 - 0.16 11.4 0.1 0.28 10.7 0.1 1.3 1 0 0 1 1 1 0 Putative methyltransferase COX5A PF02284.16 ADV19488.1 - 2.5e-42 143.0 0.1 3.2e-42 142.7 0.1 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Va Pilin_GH PF16734.5 ADV19488.1 - 0.0064 16.8 0.4 0.041 14.2 0.4 1.9 1 1 1 2 2 2 1 Type IV pilin-like G and H, putative BP28CT PF08146.12 ADV19488.1 - 0.095 12.5 0.0 0.13 12.1 0.0 1.3 1 1 0 1 1 1 0 BP28CT (NUC211) domain Hid1 PF12722.7 ADV19491.1 - 7.8 4.5 6.2 8.9 4.3 6.2 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Mannosyl_trans PF05007.13 ADV19492.1 - 1.6e-59 201.9 13.4 3.9e-59 200.6 13.4 1.6 1 1 0 1 1 1 1 Mannosyltransferase (PIG-M) Arf PF00025.21 ADV19493.1 - 3.9e-66 221.8 0.0 4.4e-66 221.6 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 ADV19493.1 - 3.4e-10 39.6 0.0 7e-07 28.7 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 ADV19493.1 - 5.1e-10 39.1 0.0 6.5e-10 38.7 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 ADV19493.1 - 2.1e-07 31.0 0.0 2.8e-07 30.6 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 ADV19493.1 - 8.6e-07 29.2 0.0 2e-06 28.0 0.0 1.6 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 ADV19493.1 - 3.7e-06 26.6 0.0 4.7e-06 26.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 ADV19493.1 - 0.0001 21.8 0.0 0.00011 21.6 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region cobW PF02492.19 ADV19493.1 - 0.12 12.0 0.0 4.7 6.8 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain PduV-EutP PF10662.9 ADV19493.1 - 0.19 11.5 0.0 0.44 10.3 0.0 1.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Bromodomain PF00439.25 ADV19494.1 - 6.5e-25 87.0 0.3 1.1e-24 86.3 0.3 1.4 1 0 0 1 1 1 1 Bromodomain Bromo_TP PF07524.13 ADV19494.1 - 0.00014 21.8 0.1 0.00099 19.1 0.0 2.2 2 0 0 2 2 2 1 Bromodomain associated Fungal_trans PF04082.18 ADV19496.1 - 3.8e-18 65.5 0.0 2.2e-17 63.0 0.0 2.2 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ADV19496.1 - 2.4e-08 34.0 6.9 4.6e-08 33.0 6.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Tau95 PF09734.9 ADV19497.1 - 3.8e-24 86.1 0.4 1.1e-23 84.7 0.2 1.9 2 1 0 2 2 2 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain Tau95_N PF17682.1 ADV19497.1 - 8.2e-13 48.7 0.0 1.8e-12 47.6 0.0 1.6 1 0 0 1 1 1 1 Tau95 Triple barrel domain Lysine_decarbox PF03641.14 ADV19499.1 - 1e-29 103.3 0.0 1.8e-29 102.5 0.0 1.4 1 0 0 1 1 1 1 Possible lysine decarboxylase Aminotran_4 PF01063.19 ADV19499.1 - 2.9e-15 56.7 0.0 4e-15 56.3 0.0 1.2 1 0 0 1 1 1 1 Amino-transferase class IV LDcluster4 PF18306.1 ADV19499.1 - 1.3e-07 31.3 0.1 7.7e-07 28.8 0.1 2.1 1 1 0 1 1 1 1 SLOG cluster4 family Glyco_hydro_cc PF11790.8 ADV19500.1 - 5.9e-70 235.6 8.7 7.2e-70 235.3 8.7 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core Ion_trans_N PF08412.10 ADV19502.1 - 0.0018 17.8 0.0 0.0025 17.4 0.0 1.3 1 0 0 1 1 1 1 Ion transport protein N-terminal BAG PF02179.16 ADV19504.1 - 8e-16 58.2 0.0 1.2e-15 57.7 0.0 1.3 1 0 0 1 1 1 1 BAG domain ubiquitin PF00240.23 ADV19504.1 - 2.8e-09 36.6 0.0 4.7e-09 35.9 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family TUG-UBL1 PF11470.8 ADV19504.1 - 0.085 13.1 0.0 0.14 12.4 0.0 1.4 1 0 0 1 1 1 0 TUG ubiquitin-like domain Blt1 PF12754.7 ADV19504.1 - 0.14 12.4 0.1 0.38 11.1 0.0 1.7 2 0 0 2 2 2 0 Blt1 N-terminal domain zf_C2H2_6 PF18450.1 ADV19504.1 - 5.4 6.8 5.3 2.5 7.9 1.4 2.2 2 0 0 2 2 2 0 Zinc Finger domain DAO PF01266.24 ADV19505.1 - 3.9e-53 181.3 0.3 4.6e-53 181.0 0.3 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.22 ADV19505.1 - 3.7e-06 26.3 0.2 0.0046 16.1 0.0 2.2 2 0 0 2 2 2 2 Glucose inhibited division protein A Pyr_redox_2 PF07992.14 ADV19505.1 - 4.6e-06 26.1 0.4 2.6e-05 23.6 0.4 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ADV19505.1 - 0.0011 19.1 0.1 0.0031 17.7 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 ADV19505.1 - 0.0022 17.1 2.0 0.026 13.6 2.0 2.0 1 1 0 1 1 1 1 FAD binding domain NAD_binding_9 PF13454.6 ADV19505.1 - 0.0023 17.9 0.1 0.068 13.2 0.1 2.2 2 0 0 2 2 2 1 FAD-NAD(P)-binding Trp_halogenase PF04820.14 ADV19505.1 - 0.0045 15.9 0.7 0.0079 15.1 0.4 1.5 2 0 0 2 2 2 1 Tryptophan halogenase Thi4 PF01946.17 ADV19505.1 - 0.0054 16.0 1.0 0.084 12.1 0.1 2.2 2 0 0 2 2 2 1 Thi4 family MCRA PF06100.11 ADV19505.1 - 0.1 11.3 0.1 0.16 10.7 0.1 1.3 1 0 0 1 1 1 0 MCRA family FAD_binding_3 PF01494.19 ADV19505.1 - 0.17 11.1 0.5 2.2 7.4 0.0 2.1 2 0 0 2 2 2 0 FAD binding domain Lycopene_cycl PF05834.12 ADV19505.1 - 0.25 10.3 0.5 5.3 6.0 0.1 2.7 3 0 0 3 3 3 0 Lycopene cyclase protein MCPVI PF02993.14 ADV19506.1 - 0.42 10.4 5.1 0.27 11.0 3.5 1.4 1 1 1 2 2 2 0 Minor capsid protein VI FA_desaturase PF00487.24 ADV19507.1 - 2.3e-27 96.4 22.5 3.9e-27 95.7 22.5 1.4 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 ADV19507.1 - 2.6e-10 40.3 0.0 5.7e-10 39.2 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain LMWPc PF01451.21 ADV19508.1 - 1.1e-26 94.0 0.0 1.3e-26 93.7 0.0 1.1 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase TSNR_N PF04705.12 ADV19508.1 - 0.0081 16.2 0.0 0.012 15.7 0.0 1.2 1 0 0 1 1 1 1 Thiostrepton-resistance methylase, N terminus Pyr_redox_2 PF07992.14 ADV19509.1 - 2.6e-30 105.7 0.0 6e-27 94.6 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ADV19509.1 - 1e-13 51.7 0.0 3.5e-12 46.7 0.0 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ADV19509.1 - 0.0052 16.4 0.0 0.29 10.7 0.0 2.4 2 1 1 3 3 3 1 FAD dependent oxidoreductase K_oxygenase PF13434.6 ADV19509.1 - 0.024 13.8 0.0 0.052 12.7 0.0 1.5 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Trp_halogenase PF04820.14 ADV19509.1 - 0.029 13.2 0.0 1.6 7.5 0.0 2.2 2 0 0 2 2 2 0 Tryptophan halogenase Pyr_redox_3 PF13738.6 ADV19509.1 - 0.062 12.6 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 ADV19509.1 - 0.23 10.6 0.4 2.1 7.5 0.0 2.5 2 1 0 3 3 3 0 FAD binding domain PQQ PF01011.21 ADV19511.1 - 0.12 12.4 0.0 0.42 10.6 0.0 1.9 1 0 0 1 1 1 0 PQQ enzyme repeat DNA_pol_B PF00136.21 ADV19512.1 - 4.4e-99 332.3 0.0 6e-99 331.8 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 ADV19512.1 - 1.2e-12 47.7 0.0 6.4e-07 28.8 0.0 2.4 2 0 0 2 2 2 2 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 ADV19512.1 - 6.9e-12 45.7 3.5 2.1e-11 44.1 3.5 1.9 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta DNA_pol_B_2 PF03175.13 ADV19512.1 - 0.0083 15.0 0.1 0.014 14.3 0.1 1.2 1 0 0 1 1 1 1 DNA polymerase type B, organellar and viral ELYS PF13934.6 ADV19514.1 - 1.1e-53 182.4 0.0 1.7e-53 181.9 0.0 1.2 1 0 0 1 1 1 1 Nuclear pore complex assembly RRM_1 PF00076.22 ADV19515.1 - 2.7e-40 136.0 0.0 2.2e-14 53.0 0.0 4.6 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ADV19515.1 - 8e-10 38.4 0.0 0.056 13.3 0.0 4.7 4 0 0 4 4 4 3 Occluded RNA-recognition motif PHM7_cyt PF14703.6 ADV19515.1 - 0.00013 22.3 0.5 3.2 7.9 0.0 4.8 4 0 0 4 4 4 1 Cytosolic domain of 10TM putative phosphate transporter RRM_7 PF16367.5 ADV19515.1 - 0.0076 16.4 0.0 9.3 6.5 0.0 3.1 3 0 0 3 3 3 2 RNA recognition motif Nup35_RRM_2 PF14605.6 ADV19515.1 - 0.018 15.0 0.0 1.4 9.0 0.0 3.2 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif Tti2 PF10521.9 ADV19515.1 - 0.025 14.2 0.0 0.063 12.8 0.0 1.7 1 0 0 1 1 1 0 Tti2 family EcsC PF12787.7 ADV19515.1 - 0.034 13.8 0.4 0.18 11.5 0.1 2.3 2 0 0 2 2 2 0 EcsC protein family DbpA PF03880.15 ADV19515.1 - 0.08 12.9 0.0 0.29 11.1 0.0 2.0 1 0 0 1 1 1 0 DbpA RNA binding domain TPR_14 PF13428.6 ADV19515.1 - 0.35 11.8 3.6 2.4 9.2 0.1 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat DSPc PF00782.20 ADV19517.1 - 3e-26 91.8 0.0 4.5e-26 91.2 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Rhodanese PF00581.20 ADV19517.1 - 0.0013 19.2 0.0 0.0093 16.5 0.0 2.4 2 1 0 2 2 2 1 Rhodanese-like domain Y_phosphatase PF00102.27 ADV19517.1 - 0.051 13.1 0.0 0.082 12.5 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Zn_clus PF00172.18 ADV19518.1 - 3.1e-08 33.6 12.3 5.9e-08 32.7 12.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain BCIP PF13862.6 ADV19519.1 - 2.2e-42 145.2 0.0 2.9e-42 144.8 0.0 1.1 1 0 0 1 1 1 1 p21-C-terminal region-binding protein HSP70 PF00012.20 ADV19520.1 - 7.3e-60 202.8 0.8 4.3e-58 196.9 0.8 2.5 1 1 0 1 1 1 1 Hsp70 protein DUF3549 PF12069.8 ADV19521.1 - 0.071 12.1 3.5 0.11 11.5 3.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3549) CorA PF01544.18 ADV19521.1 - 0.23 10.7 9.4 0.93 8.8 9.4 2.0 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein dCache_1 PF02743.18 ADV19521.1 - 7 6.4 5.7 4.6 6.9 0.9 2.1 1 1 1 2 2 2 0 Cache domain Elf1 PF05129.13 ADV19522.1 - 1.6e-27 95.4 3.9 1.6e-27 95.4 3.9 1.7 2 0 0 2 2 2 1 Transcription elongation factor Elf1 like Cript PF10235.9 ADV19522.1 - 0.12 13.0 1.8 0.24 12.0 1.8 1.5 1 0 0 1 1 1 0 Microtubule-associated protein CRIPT CDC45 PF02724.14 ADV19522.1 - 6.3 5.0 7.3 6.6 4.9 7.3 1.1 1 0 0 1 1 1 0 CDC45-like protein MFS_1 PF07690.16 ADV19523.1 - 2e-30 105.9 46.4 8.7e-22 77.5 9.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily UCR_UQCRX_QCR9 PF05365.12 ADV19523.1 - 0.0012 18.8 0.8 0.014 15.3 0.0 3.0 3 0 0 3 3 3 1 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like DUF4220 PF13968.6 ADV19523.1 - 0.039 13.4 2.4 0.069 12.5 2.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4220) MFS_1 PF07690.16 ADV19524.1 - 5.1e-25 88.1 54.4 3.6e-21 75.5 33.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2456 PF10445.9 ADV19525.1 - 9e-18 64.1 3.9 1.7e-17 63.3 3.9 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2456) Nucleopor_Nup85 PF07575.13 ADV19526.1 - 1.8e-62 211.7 0.0 3.5e-35 121.6 0.0 2.2 2 0 0 2 2 2 2 Nup85 Nucleoporin DUF4479 PF14794.6 ADV19526.1 - 0.072 12.9 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4479) Mistic PF11458.8 ADV19526.1 - 0.26 11.3 0.7 0.7 9.9 0.1 2.0 2 0 0 2 2 2 0 Membrane-integrating protein Mistic Iso_dh PF00180.20 ADV19527.1 - 1e-74 251.8 0.0 1.3e-74 251.5 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase LprI PF07007.12 ADV19528.1 - 0.12 13.0 0.1 0.34 11.6 0.1 1.7 1 0 0 1 1 1 0 Lysozyme inhibitor LprI NmrA PF05368.13 ADV19529.1 - 6.7e-10 38.9 0.0 8.1e-10 38.6 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 ADV19529.1 - 0.00022 21.2 0.0 0.00049 20.0 0.0 1.6 2 0 0 2 2 2 1 NAD(P)H-binding Semialdhyde_dh PF01118.24 ADV19529.1 - 0.12 12.8 0.1 0.51 10.8 0.0 2.0 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain Pkinase PF00069.25 ADV19530.1 - 5.6e-31 107.9 0.0 9.2e-31 107.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV19530.1 - 9.3e-20 71.0 0.0 1.5e-19 70.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase GRP PF07172.11 ADV19530.1 - 5 7.9 7.0 4.2 8.1 5.1 1.9 1 1 0 1 1 1 0 Glycine rich protein family zf-RING_4 PF14570.6 ADV19531.1 - 4.3e-17 61.6 10.7 7.3e-17 60.9 10.7 1.4 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-C3HC4_3 PF13920.6 ADV19531.1 - 2.8e-05 23.9 5.4 4.5e-05 23.2 5.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ADV19531.1 - 0.096 13.0 8.3 0.17 12.2 8.3 1.4 1 0 0 1 1 1 0 Ring finger domain FYVE PF01363.21 ADV19531.1 - 0.14 12.3 2.4 0.29 11.3 2.4 1.5 1 0 0 1 1 1 0 FYVE zinc finger Baculo_IE-1 PF05290.11 ADV19531.1 - 0.69 9.9 2.9 1.2 9.0 2.9 1.3 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) zf-RING_5 PF14634.6 ADV19531.1 - 1.5 8.8 7.4 2.7 8.0 7.4 1.4 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_2 PF13923.6 ADV19531.1 - 1.8 8.5 9.8 3.4 7.6 9.8 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) PCMT PF01135.19 ADV19532.1 - 4.6e-60 203.0 0.0 6e-60 202.6 0.0 1.0 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_32 PF13679.6 ADV19532.1 - 7.7e-06 26.0 0.0 1.2e-05 25.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ADV19532.1 - 1.7e-05 24.7 0.0 2.9e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ADV19532.1 - 0.0023 17.5 0.0 0.0034 16.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 ADV19532.1 - 0.0025 18.5 0.0 0.0054 17.4 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ADV19532.1 - 0.0038 17.1 0.0 0.0052 16.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 ADV19532.1 - 0.025 14.0 0.0 0.04 13.3 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_4 PF02390.17 ADV19532.1 - 0.13 11.7 0.0 0.22 11.0 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase FA_hydroxylase PF04116.13 ADV19533.1 - 9.2e-23 81.1 14.3 9.2e-23 81.1 14.3 2.3 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily PDR_assoc PF08370.11 ADV19533.1 - 0.0051 16.5 1.9 0.018 14.8 0.2 2.4 2 0 0 2 2 2 1 Plant PDR ABC transporter associated SNARE_assoc PF09335.11 ADV19533.1 - 0.018 15.5 2.2 4.4 7.8 0.1 2.9 3 1 0 3 3 3 0 SNARE associated Golgi protein DUF373 PF04123.13 ADV19533.1 - 0.071 12.6 0.1 0.11 11.9 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF373) PEP-CTERM PF07589.11 ADV19534.1 - 0.084 13.0 0.4 0.27 11.4 0.4 1.9 1 0 0 1 1 1 0 PEP-CTERM motif Glyco_transf_15 PF01793.16 ADV19535.1 - 2.4e-120 401.7 8.1 3e-120 401.4 8.1 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase MOZ_SAS PF01853.18 ADV19536.1 - 1.4e-81 272.5 0.6 1.9e-81 272.0 0.6 1.2 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 ADV19536.1 - 2.1e-23 81.7 2.2 4.2e-23 80.7 2.2 1.6 1 0 0 1 1 1 1 MYST family zinc finger domain Tudor-knot PF11717.8 ADV19536.1 - 1.6e-21 75.9 0.0 3.6e-21 74.8 0.0 1.6 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain HTH_Mga PF08280.11 ADV19536.1 - 0.00016 21.6 0.6 0.00034 20.6 0.6 1.5 1 0 0 1 1 1 1 M protein trans-acting positive regulator (MGA) HTH domain Acetyltransf_7 PF13508.7 ADV19536.1 - 0.00052 20.4 0.0 0.0011 19.4 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ADV19536.1 - 0.0071 16.6 0.0 0.017 15.3 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family HTH_11 PF08279.12 ADV19536.1 - 0.017 15.1 0.1 0.037 14.0 0.1 1.5 1 0 0 1 1 1 0 HTH domain SUR7 PF06687.12 ADV19537.1 - 0.00037 20.2 22.9 0.011 15.4 22.9 2.0 1 1 0 1 1 1 1 SUR7/PalI family zf-LITAF-like PF10601.9 ADV19537.1 - 0.0069 16.6 4.1 2.6 8.4 0.0 3.4 3 0 0 3 3 3 1 LITAF-like zinc ribbon domain DUF3671 PF12420.8 ADV19537.1 - 0.046 13.8 0.5 0.48 10.5 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function Claudin_3 PF06653.11 ADV19537.1 - 1.4 8.9 14.1 3 7.8 14.1 1.5 1 1 0 1 1 1 0 Tight junction protein, Claudin-like Mito_carr PF00153.27 ADV19538.1 - 4.2e-41 138.8 6.2 2e-15 56.5 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein zf-rbx1 PF12678.7 ADV19539.1 - 5.5e-20 71.4 10.5 8.2e-20 70.8 10.5 1.2 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 ADV19539.1 - 9e-16 57.7 7.2 1.3e-15 57.2 7.2 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 ADV19539.1 - 0.0016 18.8 12.1 0.026 14.9 12.1 2.2 1 1 0 1 1 1 1 Ring finger domain zf-HC5HC2H_2 PF13832.6 ADV19539.1 - 0.0073 16.4 2.8 0.012 15.7 2.8 1.5 1 0 0 1 1 1 1 PHD-zinc-finger like domain zf-C3HC4 PF00097.25 ADV19539.1 - 0.021 14.7 9.3 0.15 12.0 9.3 2.2 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.8 ADV19539.1 - 0.052 13.7 7.7 0.25 11.6 7.8 1.9 1 1 1 2 2 2 0 FANCL C-terminal domain zf-RING_UBOX PF13445.6 ADV19539.1 - 0.27 11.3 5.5 1.4 9.1 5.5 2.2 1 1 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_2 PF13923.6 ADV19539.1 - 0.43 10.5 13.6 0.37 10.7 7.7 2.4 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 ADV19539.1 - 2.3 7.9 13.1 0.41 10.3 3.5 2.2 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type zf-RING_11 PF17123.5 ADV19539.1 - 7.9 6.3 18.9 1.4e+02 2.3 17.0 2.7 2 1 0 2 2 2 0 RING-like zinc finger Nop14 PF04147.12 ADV19540.1 - 3.3e-285 948.7 14.3 4e-285 948.5 14.3 1.1 1 0 0 1 1 1 1 Nop14-like family TetR_C_6 PF13977.6 ADV19540.1 - 0.031 14.5 0.1 0.13 12.5 0.1 2.1 2 0 0 2 2 2 0 BetI-type transcriptional repressor, C-terminal Response_reg PF00072.24 ADV19541.1 - 1.2e-21 77.0 0.0 1.7e-15 57.2 0.0 2.7 2 0 0 2 2 2 2 Response regulator receiver domain Oxidored_nitro PF00148.19 ADV19541.1 - 0.12 11.1 0.0 0.18 10.5 0.0 1.2 1 0 0 1 1 1 0 Nitrogenase component 1 type Oxidoreductase LSM PF01423.22 ADV19543.1 - 3e-18 65.3 0.1 4.1e-18 64.8 0.1 1.2 1 0 0 1 1 1 1 LSM domain Curto_V2 PF07325.11 ADV19543.1 - 0.037 13.9 0.1 0.043 13.7 0.1 1.3 1 0 0 1 1 1 0 Curtovirus V2 protein Hfq PF17209.3 ADV19543.1 - 0.062 13.0 0.1 0.099 12.3 0.1 1.3 1 0 0 1 1 1 0 Hfq protein Aminotran_1_2 PF00155.21 ADV19544.1 - 3.3e-60 204.2 0.0 3.9e-60 204.0 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 ADV19544.1 - 0.01 14.8 0.0 0.019 13.9 0.0 1.4 1 0 0 1 1 1 0 Aminotransferase class-V Pkinase PF00069.25 ADV19545.1 - 1.1e-65 221.6 0.0 1.6e-65 221.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV19545.1 - 4.5e-37 127.7 0.0 6.2e-37 127.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ADV19545.1 - 2.7e-08 33.5 0.0 4.5e-08 32.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 ADV19545.1 - 3.7e-05 23.2 0.5 0.00012 21.5 0.2 2.0 3 0 0 3 3 3 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 ADV19545.1 - 0.00053 18.9 0.5 0.0035 16.2 0.1 2.1 1 1 1 2 2 2 1 Fungal protein kinase APH PF01636.23 ADV19545.1 - 0.0014 18.6 0.3 0.0028 17.6 0.3 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ADV19545.1 - 0.058 12.3 0.2 0.081 11.8 0.2 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Aminotran_1_2 PF00155.21 ADV19547.1 - 7e-12 45.2 0.0 2.4e-11 43.4 0.0 1.9 3 0 0 3 3 3 1 Aminotransferase class I and II Glyco_hydro_56 PF01630.18 ADV19547.1 - 0.13 11.3 0.0 0.21 10.6 0.0 1.2 1 0 0 1 1 1 0 Hyaluronidase zf-C3HC4_3 PF13920.6 ADV19548.1 - 0.05 13.5 1.3 0.15 11.9 1.3 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Acyltransferase PF01553.21 ADV19549.1 - 5.9e-22 77.7 0.0 1.1e-21 76.9 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 ADV19549.1 - 4.1e-05 23.6 1.2 8.3e-05 22.6 1.2 1.4 1 0 0 1 1 1 1 Acyltransferase C-terminus Na_Ca_ex PF01699.24 ADV19550.1 - 1.7e-39 135.2 31.3 8.3e-21 74.5 12.3 2.8 3 0 0 3 3 3 2 Sodium/calcium exchanger protein PhoLip_ATPase_C PF16212.5 ADV19551.1 - 1.3e-78 264.3 24.6 2.7e-78 263.2 24.6 1.6 1 0 0 1 1 1 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 ADV19551.1 - 3.4e-22 77.9 1.5 4.5e-22 77.5 0.1 2.0 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 ADV19551.1 - 4.1e-12 46.0 0.0 1.6e-11 44.1 0.0 2.0 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 ADV19551.1 - 5.2e-12 46.5 1.7 1e-07 32.4 0.3 3.3 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 ADV19551.1 - 4.6e-10 39.3 0.0 1.1e-09 38.0 0.0 1.7 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.12 ADV19551.1 - 0.0017 18.1 0.1 0.019 14.7 0.0 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase TetR_C_33 PF13305.6 ADV19551.1 - 0.078 13.7 0.1 3.9 8.3 0.0 2.5 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Proteasome PF00227.26 ADV19552.1 - 8.3e-37 126.5 0.0 9.7e-37 126.3 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit Trans_coact PF16805.5 ADV19552.1 - 0.19 11.8 0.0 3.2 7.9 0.0 2.2 2 0 0 2 2 2 0 Phage late-transcription coactivator MIF4G PF02854.19 ADV19553.1 - 4.2e-47 160.5 0.3 6.8e-47 159.8 0.3 1.3 1 0 0 1 1 1 1 MIF4G domain eIF_4G1 PF12152.8 ADV19553.1 - 2.2e-19 69.4 0.0 2.2e-19 69.4 0.0 2.3 3 0 0 3 3 3 1 Eukaryotic translation initiation factor 4G1 SAPS PF04499.15 ADV19553.1 - 0.066 12.0 0.1 0.066 12.0 0.1 2.5 3 0 0 3 3 3 0 SIT4 phosphatase-associated protein Tim54 PF11711.8 ADV19553.1 - 0.11 11.3 6.6 0.85 8.3 4.0 2.5 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 ESM4 PF15952.5 ADV19553.1 - 0.16 12.4 1.1 0.49 10.8 1.1 1.8 1 0 0 1 1 1 0 Enhancer of split M4 family RabGAP-TBC PF00566.18 ADV19554.1 - 4e-14 52.8 0.0 1.7e-13 50.7 0.0 1.9 2 0 0 2 2 2 1 Rab-GTPase-TBC domain GCV_T PF01571.21 ADV19555.1 - 2e-06 27.4 0.0 2.9e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain Myotub-related PF06602.14 ADV19556.1 - 6.9e-146 485.7 0.3 9e-146 485.3 0.3 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Y_phosphatase3 PF13350.6 ADV19556.1 - 0.0023 18.0 0.1 0.0057 16.6 0.0 1.7 2 0 0 2 2 2 1 Tyrosine phosphatase family DSPc PF00782.20 ADV19556.1 - 0.0083 15.9 0.0 0.023 14.5 0.0 1.7 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ADV19556.1 - 0.088 12.4 0.0 0.18 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein-tyrosine phosphatase GRAM PF02893.20 ADV19556.1 - 0.11 12.4 0.0 0.29 11.0 0.0 1.7 1 0 0 1 1 1 0 GRAM domain Kelch_1 PF01344.25 ADV19557.1 - 5.3e-43 144.4 4.1 7.4e-09 35.1 0.0 6.2 6 0 0 6 6 6 6 Kelch motif Kelch_5 PF13854.6 ADV19557.1 - 2.4e-37 126.4 7.7 3.1e-08 33.4 0.1 6.3 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 ADV19557.1 - 5e-37 125.0 12.0 3.6e-07 30.2 0.2 6.3 3 2 3 6 6 6 6 Kelch motif Kelch_4 PF13418.6 ADV19557.1 - 5.9e-34 115.8 17.4 1.5e-06 28.1 0.1 6.3 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_2 PF07646.15 ADV19557.1 - 3.4e-33 112.4 5.1 6.1e-07 29.2 0.0 6.3 6 0 0 6 6 6 6 Kelch motif Kelch_3 PF13415.6 ADV19557.1 - 1.4e-29 101.7 12.4 3.9e-06 27.0 0.1 6.8 6 1 0 6 6 6 5 Galactose oxidase, central domain zf-CSL PF05207.13 ADV19558.1 - 4.3e-20 71.2 0.2 7.5e-20 70.4 0.2 1.4 1 0 0 1 1 1 1 CSL zinc finger Transket_pyr PF02779.24 ADV19559.1 - 4.9e-37 127.3 0.0 7.3e-37 126.8 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 ADV19559.1 - 1.2e-23 83.4 0.0 1.4e-22 79.9 0.0 2.2 1 1 0 1 1 1 1 Transketolase, C-terminal domain UPF0047 PF01894.17 ADV19560.1 - 5.9e-35 119.9 0.0 6.6e-35 119.7 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family UPF0047 TauD PF02668.16 ADV19561.1 - 1.6e-64 218.3 2.6 2.4e-64 217.8 2.0 1.6 1 1 1 2 2 2 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.12 ADV19561.1 - 0.041 14.5 0.2 0.14 12.9 0.2 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF971) CsiD PF08943.10 ADV19561.1 - 0.074 12.1 0.0 0.13 11.4 0.0 1.3 1 0 0 1 1 1 0 CsiD MIF4G PF02854.19 ADV19562.1 - 5.6e-46 156.8 0.1 9.3e-46 156.1 0.1 1.4 1 0 0 1 1 1 1 MIF4G domain eIF_4G1 PF12152.8 ADV19562.1 - 5.9e-22 77.6 0.0 1.5e-21 76.3 0.0 1.7 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 4G1 SAPS PF04499.15 ADV19562.1 - 4.2 6.0 17.6 1.1 7.9 0.0 2.4 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein PIG-U PF06728.13 ADV19563.1 - 8.5e-102 341.0 23.5 1.1e-101 340.7 23.5 1.1 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U 8TM_micro PF17028.5 ADV19563.1 - 0.012 15.3 4.6 0.023 14.4 4.6 1.4 1 0 0 1 1 1 0 8TM Microsporidial transmembrane domain RRM_1 PF00076.22 ADV19564.1 - 9.4e-18 63.8 0.0 1.3e-17 63.3 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ADV19564.1 - 0.00052 19.8 0.0 0.00097 18.9 0.0 1.4 1 1 0 1 1 1 1 Occluded RNA-recognition motif RRM_5 PF13893.6 ADV19564.1 - 0.0036 16.9 0.0 0.0055 16.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SH3_9 PF14604.6 ADV19565.1 - 2.6e-10 40.0 0.0 6.1e-10 38.8 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ADV19565.1 - 6.4e-10 38.5 0.0 1.1e-09 37.8 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 ADV19565.1 - 9.8e-05 22.0 0.0 0.00016 21.3 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain DUF2076 PF09849.9 ADV19565.1 - 1.6 8.7 12.4 0.13 12.3 6.4 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) Pkinase PF00069.25 ADV19566.1 - 9.3e-66 221.9 0.0 1.2e-65 221.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV19566.1 - 5.6e-33 114.3 0.0 7.9e-33 113.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ADV19566.1 - 0.039 13.3 0.0 0.064 12.6 0.0 1.5 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 ADV19566.1 - 0.15 11.9 3.3 0.84 9.5 3.3 2.0 1 1 0 1 1 1 0 Phosphotransferase enzyme family TFIIA PF03153.13 ADV19566.1 - 4.4 7.2 7.6 6.5 6.6 7.6 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit GIY-YIG PF01541.24 ADV19567.1 - 1.2e-13 51.1 0.0 3.5e-13 49.6 0.0 1.8 2 0 0 2 2 2 1 GIY-YIG catalytic domain Eapp_C PF10238.9 ADV19567.1 - 0.17 11.9 2.1 0.18 11.9 0.5 1.8 2 0 0 2 2 2 0 E2F-associated phosphoprotein DUF2039 PF10217.9 ADV19567.1 - 2.2 8.7 7.5 0.11 12.9 0.7 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2039) Alpha-amylase_C PF02806.18 ADV19568.1 - 8.6e-27 93.5 0.0 2.1e-26 92.2 0.0 1.7 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain CBM_48 PF02922.18 ADV19568.1 - 3.4e-18 65.8 0.0 9.9e-18 64.3 0.0 1.9 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Alpha-amylase PF00128.24 ADV19568.1 - 1.3e-16 61.1 0.2 2.6e-12 47.0 0.1 2.3 1 1 1 2 2 2 2 Alpha amylase, catalytic domain hDGE_amylase PF14701.6 ADV19568.1 - 0.094 11.8 0.1 0.18 10.9 0.1 1.4 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain DUF2724 PF10893.8 ADV19568.1 - 0.14 12.0 0.1 0.45 10.4 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2724) WD40 PF00400.32 ADV19570.1 - 1.6e-12 47.7 6.1 0.00042 21.1 0.1 5.2 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV19570.1 - 0.0023 18.2 0.0 1.1 9.6 0.0 3.1 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ADV19570.1 - 0.086 12.1 0.0 0.14 11.4 0.0 1.4 1 0 0 1 1 1 0 WD40-like domain PIP5K PF01504.18 ADV19571.1 - 6.3e-102 340.5 0.3 1e-101 339.7 0.3 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Rad51 PF08423.11 ADV19572.1 - 1.2e-12 47.6 0.0 1.8e-12 47.1 0.0 1.3 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.6 ADV19572.1 - 3.6e-10 39.7 0.0 5.9e-10 39.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 ADV19572.1 - 0.021 15.3 0.1 0.046 14.2 0.0 1.6 2 0 0 2 2 2 0 ABC transporter SAM_2 PF07647.17 ADV19572.1 - 0.031 14.4 0.1 0.2 11.8 0.0 2.5 2 1 1 3 3 3 0 SAM domain (Sterile alpha motif) IstB_IS21 PF01695.17 ADV19572.1 - 0.039 13.7 0.0 0.091 12.5 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA PF00004.29 ADV19572.1 - 0.052 14.0 0.3 0.38 11.2 0.1 2.0 1 1 1 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 ADV19572.1 - 0.067 12.9 0.0 0.15 11.8 0.0 1.6 1 1 0 1 1 1 0 AAA domain DegS PF05384.11 ADV19572.1 - 0.12 11.8 0.0 7.4 6.0 0.0 2.2 2 0 0 2 2 2 0 Sensor protein DegS AAA_18 PF13238.6 ADV19572.1 - 0.14 12.7 0.0 0.27 11.8 0.0 1.7 1 1 0 1 1 1 0 AAA domain Ribosomal_L13 PF00572.18 ADV19576.1 - 3.1e-50 169.6 0.0 3.9e-50 169.3 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L13 Rep_fac-A_3 PF08661.11 ADV19577.1 - 6.7e-27 93.9 0.0 7.9e-27 93.7 0.0 1.0 1 0 0 1 1 1 1 Replication factor A protein 3 Proteasome PF00227.26 ADV19578.1 - 2.3e-43 147.9 0.1 2.6e-43 147.7 0.1 1.0 1 0 0 1 1 1 1 Proteasome subunit zf-LYAR PF08790.11 ADV19579.1 - 3.7e-15 55.5 3.2 7.9e-15 54.5 3.2 1.6 1 0 0 1 1 1 1 LYAR-type C2HC zinc finger DUF4573 PF15140.6 ADV19579.1 - 0.0013 18.5 9.3 0.017 14.9 0.4 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4573) zf-C2H2 PF00096.26 ADV19579.1 - 0.0025 18.2 0.9 0.0025 18.2 0.9 1.8 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 ADV19579.1 - 0.0031 17.8 0.1 0.0031 17.8 0.1 2.0 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding GRP PF07172.11 ADV19579.1 - 0.012 16.3 2.5 0.012 16.3 2.5 2.6 2 0 0 2 2 2 0 Glycine rich protein family GEP5 PF17053.5 ADV19579.1 - 0.058 13.2 0.4 0.089 12.6 0.4 1.3 1 0 0 1 1 1 0 Genetic interactor of prohibitin 5 zf_UBZ PF18439.1 ADV19579.1 - 0.061 12.9 1.0 7.3 6.3 0.1 2.4 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-met PF12874.7 ADV19579.1 - 0.53 10.7 2.3 0.8 10.2 0.2 2.2 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 ADV19579.1 - 0.94 10.5 6.3 0.51 11.3 0.7 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ADV19579.1 - 3.6 8.2 6.7 11 6.6 1.5 2.5 2 0 0 2 2 2 0 Zinc-finger double domain Sterol_MT_C PF08498.10 ADV19580.1 - 2.1e-26 92.0 0.8 3.3e-26 91.4 0.8 1.3 1 0 0 1 1 1 1 Sterol methyltransferase C-terminal Methyltransf_31 PF13847.6 ADV19580.1 - 2.1e-18 66.6 0.0 3e-18 66.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ADV19580.1 - 6.3e-17 62.0 0.0 1.3e-16 61.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ADV19580.1 - 4.5e-15 56.1 0.0 8.8e-15 55.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ADV19580.1 - 2.1e-14 53.7 0.0 3e-14 53.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 ADV19580.1 - 3.6e-14 52.7 0.0 4.9e-14 52.3 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.12 ADV19580.1 - 5.1e-11 43.2 0.1 1.2e-10 42.0 0.0 1.7 2 0 0 2 2 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ADV19580.1 - 7.6e-08 32.0 0.0 1.2e-07 31.3 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PCMT PF01135.19 ADV19580.1 - 2.5e-06 27.4 0.0 3.6e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_3 PF01596.17 ADV19580.1 - 0.00049 19.3 0.0 0.00099 18.3 0.0 1.5 1 0 0 1 1 1 1 O-methyltransferase MTS PF05175.14 ADV19580.1 - 0.0018 17.8 0.0 0.0038 16.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_15 PF09445.10 ADV19580.1 - 0.0042 16.7 0.1 0.0066 16.0 0.1 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase UPF0020 PF01170.18 ADV19580.1 - 0.0094 15.6 0.0 0.015 15.0 0.0 1.3 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 MetW PF07021.12 ADV19580.1 - 0.014 15.0 0.0 0.021 14.4 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_2 PF00891.18 ADV19580.1 - 0.024 13.9 0.0 0.037 13.3 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase domain HRM PF02793.22 ADV19580.1 - 0.028 14.7 0.4 0.081 13.2 0.4 1.7 1 0 0 1 1 1 0 Hormone receptor domain Methyltransf_24 PF13578.6 ADV19580.1 - 0.038 15.0 0.0 0.2 12.7 0.0 2.3 2 0 0 2 2 1 0 Methyltransferase domain Methyltransf_5 PF01795.19 ADV19580.1 - 0.085 12.3 0.0 0.13 11.7 0.0 1.2 1 0 0 1 1 1 0 MraW methylase family PrmA PF06325.13 ADV19580.1 - 0.094 12.1 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) FtsJ PF01728.19 ADV19580.1 - 0.15 12.1 0.0 0.4 10.8 0.0 1.7 1 0 0 1 1 1 0 FtsJ-like methyltransferase PI3Ka PF00613.20 ADV19581.1 - 1.2e-49 168.2 0.0 2.4e-49 167.3 0.0 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 ADV19581.1 - 1.1e-47 163.0 0.0 8.6e-44 150.2 0.0 2.3 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3K_C2 PF00792.24 ADV19581.1 - 4.6e-35 120.6 0.0 8.1e-35 119.8 0.0 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 HIP1_clath_bdg PF16515.5 ADV19581.1 - 0.0094 16.5 0.0 0.03 14.9 0.0 1.8 1 0 0 1 1 1 1 Clathrin-binding domain of Huntingtin-interacting protein 1 CENP-H PF05837.12 ADV19581.1 - 0.26 11.7 5.5 0.089 13.2 0.6 2.3 2 0 0 2 2 2 0 Centromere protein H (CENP-H) Acyltransferase PF01553.21 ADV19582.1 - 3.6e-13 49.3 0.0 6.5e-13 48.5 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase Rgp1 PF08737.10 ADV19583.1 - 4.1e-55 187.6 0.0 1.2e-54 186.2 0.0 1.7 2 0 0 2 2 2 1 Rgp1 Arrestin_C PF02752.22 ADV19583.1 - 5.6e-05 23.6 0.0 0.087 13.3 0.0 2.9 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 ADV19583.1 - 0.0012 18.9 0.0 0.29 11.2 0.0 2.6 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain VirC2 PF07181.11 ADV19583.1 - 0.097 12.1 2.2 0.16 11.4 0.7 2.0 2 0 0 2 2 2 0 VirC2 protein CoA_transf_3 PF02515.17 ADV19584.1 - 5.8e-129 430.4 0.0 6.7e-129 430.2 0.0 1.0 1 0 0 1 1 1 1 CoA-transferase family III DASH_Dad3 PF08656.10 ADV19587.1 - 5.1e-18 64.9 1.0 6.9e-18 64.5 1.0 1.1 1 0 0 1 1 1 1 DASH complex subunit Dad3 Pal1 PF08316.11 ADV19588.1 - 8.2e-10 39.6 2.0 1.4e-09 38.9 0.1 2.4 3 0 0 3 3 3 1 Pal1 cell morphology protein MFS_1 PF07690.16 ADV19589.1 - 2.2e-12 46.6 31.5 2.2e-12 46.6 31.5 2.6 1 1 0 1 1 1 1 Major Facilitator Superfamily Bud13 PF09736.9 ADV19590.1 - 7e-44 149.7 17.3 7e-44 149.7 17.3 2.3 2 0 0 2 2 2 1 Pre-mRNA-splicing factor of RES complex DUF1752 PF08550.10 ADV19591.1 - 3.3e-09 36.4 0.1 1e-08 34.8 0.1 1.9 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) DUF692 PF05114.13 ADV19592.1 - 0.11 11.7 0.0 0.19 10.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF692) HD_3 PF13023.6 ADV19592.1 - 0.53 10.2 4.7 4.8 7.1 0.1 3.1 2 1 1 3 3 3 0 HD domain PKD_channel PF08016.12 ADV19593.1 - 9.9 4.7 18.8 1.6 7.4 9.8 2.4 1 1 2 3 3 3 0 Polycystin cation channel Methyltransf_11 PF08241.12 ADV19594.1 - 5.3e-05 23.8 0.0 0.00059 20.4 0.0 2.6 3 1 0 3 3 3 1 Methyltransferase domain Methyltransf_23 PF13489.6 ADV19594.1 - 0.0027 17.6 0.0 0.0047 16.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ADV19594.1 - 0.044 14.5 0.0 4.3 8.1 0.0 2.9 3 0 0 3 3 3 0 Methyltransferase domain Methyltransf_12 PF08242.12 ADV19594.1 - 0.073 13.8 0.0 0.25 12.1 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase domain RST PF12174.8 ADV19594.1 - 0.15 12.0 0.1 7.8 6.5 0.1 2.5 2 0 0 2 2 2 0 RCD1-SRO-TAF4 (RST) plant domain Nucleoporin_FG PF13634.6 ADV19595.1 - 7.1e-21 74.9 116.0 7.6e-13 49.1 35.2 4.3 1 1 2 3 3 3 3 Nucleoporin FG repeat region HBM PF16591.5 ADV19595.1 - 1.9e-05 24.3 4.3 0.038 13.4 0.2 2.3 2 0 0 2 2 2 2 Helical bimodular sensor domain AAA_13 PF13166.6 ADV19595.1 - 0.00053 18.8 5.3 0.00081 18.2 5.3 1.3 1 0 0 1 1 1 1 AAA domain SlyX PF04102.12 ADV19595.1 - 0.0012 19.4 10.2 0.3 11.7 0.0 4.5 3 1 1 4 4 4 1 SlyX FliJ PF02050.16 ADV19595.1 - 0.055 13.7 12.2 11 6.2 0.1 4.2 3 1 0 3 3 3 0 Flagellar FliJ protein Nup88 PF10168.9 ADV19595.1 - 0.056 11.2 5.4 0.29 8.9 0.6 2.0 2 0 0 2 2 2 0 Nuclear pore component CLZ PF16526.5 ADV19595.1 - 0.11 12.9 4.5 11 6.5 0.2 3.5 2 1 1 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF1664 PF07889.12 ADV19595.1 - 0.12 12.4 5.3 4.6 7.3 0.3 3.2 2 2 1 3 3 3 0 Protein of unknown function (DUF1664) AIP3 PF03915.13 ADV19595.1 - 0.12 11.4 6.4 0.18 10.9 6.4 1.2 1 0 0 1 1 1 0 Actin interacting protein 3 Fib_alpha PF08702.10 ADV19595.1 - 0.17 12.1 15.1 0.21 11.8 2.0 3.5 1 1 3 4 4 4 0 Fibrinogen alpha/beta chain family DUF1241 PF06840.11 ADV19595.1 - 0.2 11.3 1.4 0.31 10.7 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1241) CENP-F_leu_zip PF10473.9 ADV19595.1 - 0.28 11.2 3.8 6.7 6.7 0.6 2.3 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Allexi_40kDa PF05549.11 ADV19595.1 - 0.31 10.5 4.4 0.43 10.0 0.5 2.2 2 0 0 2 2 2 0 Allexivirus 40kDa protein LMBR1 PF04791.16 ADV19595.1 - 0.36 9.7 1.0 0.49 9.2 1.0 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein AATF-Che1 PF13339.6 ADV19595.1 - 0.39 11.4 8.7 1.6 9.4 6.2 2.7 1 1 1 2 2 2 0 Apoptosis antagonizing transcription factor FapA PF03961.13 ADV19595.1 - 0.48 9.0 6.4 3 6.4 0.7 2.1 1 1 1 2 2 2 0 Flagellar Assembly Protein A Prominin PF05478.11 ADV19595.1 - 0.65 7.9 6.7 2.6 5.9 6.7 1.7 1 1 0 1 1 1 0 Prominin LPP PF04728.13 ADV19595.1 - 0.69 10.3 7.4 15 6.0 0.2 3.6 2 2 0 3 3 3 0 Lipoprotein leucine-zipper EzrA PF06160.12 ADV19595.1 - 1.2 7.2 10.8 12 3.9 0.3 3.1 2 1 1 3 3 3 0 Septation ring formation regulator, EzrA BRE1 PF08647.11 ADV19595.1 - 1.4 9.0 7.5 4.8 7.3 0.8 3.1 3 0 0 3 3 3 0 BRE1 E3 ubiquitin ligase Baculo_PEP_C PF04513.12 ADV19595.1 - 1.5 8.9 9.1 0.96 9.5 1.6 2.5 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DNA_repr_REX1B PF14966.6 ADV19595.1 - 1.6 9.4 5.7 3.6 8.3 0.2 3.0 3 0 0 3 3 3 0 DNA repair REX1-B BLOC1_2 PF10046.9 ADV19595.1 - 1.8 8.9 9.7 4.3 7.7 0.2 3.6 3 1 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Apolipoprotein PF01442.18 ADV19595.1 - 3.4 7.5 7.9 2.6 7.9 1.5 2.5 1 1 1 2 2 2 0 Apolipoprotein A1/A4/E domain DivIC PF04977.15 ADV19595.1 - 3.6 7.4 8.0 19 5.1 0.3 3.6 2 1 1 3 3 3 0 Septum formation initiator Vps51 PF08700.11 ADV19595.1 - 4 7.6 8.9 3.3 7.8 0.5 3.0 3 0 0 3 3 3 0 Vps51/Vps67 DUF4407 PF14362.6 ADV19595.1 - 4.3 6.6 9.9 64 2.7 10.0 2.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) TACC_C PF05010.14 ADV19595.1 - 6.2 6.6 10.2 5.6 6.7 1.4 2.9 1 1 0 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Med9 PF07544.13 ADV19595.1 - 6.2 7.0 8.4 3.2 7.9 0.3 3.5 2 2 1 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 PfkB PF00294.24 ADV19596.1 - 3e-08 33.3 0.0 4.3e-08 32.8 0.0 1.2 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Pkinase PF00069.25 ADV19597.1 - 2.1e-64 217.4 0.0 2.6e-64 217.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV19597.1 - 1e-25 90.5 0.0 1.4e-25 90.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ADV19597.1 - 0.00011 21.7 0.0 0.0013 18.1 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 ADV19597.1 - 0.058 12.3 0.0 0.079 11.9 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 ADV19597.1 - 0.089 12.7 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family DPM3 PF08285.11 ADV19598.1 - 1.6e-29 101.9 0.0 1.8e-29 101.8 0.0 1.0 1 0 0 1 1 1 1 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) CTP_transf_like PF01467.26 ADV19600.1 - 1.3e-23 83.8 0.0 2.3e-23 83.0 0.0 1.4 1 0 0 1 1 1 1 Cytidylyltransferase-like SapA PF02199.15 ADV19600.1 - 0.035 14.4 2.8 0.076 13.3 0.8 2.2 2 0 0 2 2 2 0 Saposin A-type domain ICE2 PF08426.10 ADV19602.1 - 1.6e-40 139.5 12.3 1.4e-39 136.4 12.3 2.0 1 1 0 1 1 1 1 ICE2 MRP-L20 PF12824.7 ADV19603.1 - 5.8e-06 26.6 1.0 1.5e-05 25.3 1.0 1.7 1 1 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 Neugrin PF06413.11 ADV19603.1 - 3.3e-05 24.0 0.0 5.5e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Neugrin MarR_2 PF12802.7 ADV19603.1 - 0.083 12.8 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 MarR family BNIP3 PF06553.12 ADV19604.1 - 0.35 10.5 5.8 0.75 9.4 5.8 1.5 1 0 0 1 1 1 0 BNIP3 FAM176 PF14851.6 ADV19604.1 - 0.41 10.3 5.0 0.71 9.5 2.0 2.2 2 0 0 2 2 2 0 FAM176 family S-antigen PF05756.11 ADV19604.1 - 9.4 6.7 8.4 13 6.3 2.4 2.4 2 0 0 2 2 2 0 S-antigen protein Cut12 PF11500.8 ADV19604.1 - 9.8 6.1 11.6 0.037 14.0 2.0 1.9 3 0 0 3 3 3 0 Spindle pole body formation-associated protein Cyclin_N PF00134.23 ADV19606.1 - 8.5e-12 44.9 0.7 1.5e-11 44.2 0.7 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C_2 PF16899.5 ADV19606.1 - 0.0033 17.8 0.1 0.017 15.5 0.0 2.2 2 0 0 2 2 2 1 Cyclin C-terminal domain TFIIB PF00382.19 ADV19606.1 - 0.14 12.2 1.1 0.29 11.2 0.0 2.1 2 0 0 2 2 2 0 Transcription factor TFIIB repeat ORC_WH_C PF18137.1 ADV19606.1 - 0.64 10.1 3.9 1.2 9.2 0.0 2.5 3 0 0 3 3 3 0 Origin recognition complex winged helix C-terminal Cyclin_N PF00134.23 ADV19608.1 - 2.5e-10 40.2 0.1 4.5e-10 39.4 0.1 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 ADV19608.1 - 2.1e-07 31.5 0.1 4.3e-07 30.4 0.0 1.6 2 0 0 2 2 2 1 Cyclin HMG_box PF00505.19 ADV19610.1 - 8.3e-18 64.6 15.9 7.9e-12 45.4 2.3 3.9 2 1 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.10 ADV19610.1 - 1.5e-13 51.1 11.7 4e-08 33.7 2.4 2.9 2 0 0 2 2 2 2 HMG-box domain DRY_EERY PF09750.9 ADV19610.1 - 6.7 7.0 9.0 22 5.3 1.4 2.6 2 0 0 2 2 2 0 Alternative splicing regulator vATP-synt_AC39 PF01992.16 ADV19611.1 - 6.7e-116 387.5 0.2 7.5e-116 387.3 0.2 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit Iso_dh PF00180.20 ADV19612.1 - 1.5e-127 425.5 0.0 1.7e-127 425.3 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase tRNA-synt_2c PF01411.19 ADV19613.1 - 0.0016 17.1 0.0 0.0022 16.6 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (A) Acyl-CoA_dh_1 PF00441.24 ADV19614.1 - 1.5e-40 138.9 0.8 3e-40 137.9 0.8 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 ADV19614.1 - 7e-37 126.5 0.1 1.4e-36 125.6 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 ADV19614.1 - 4.2e-27 94.2 0.1 2.1e-26 91.9 0.0 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 ADV19614.1 - 7.9e-14 52.1 0.7 1.2e-13 51.5 0.1 1.6 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.8 ADV19614.1 - 0.075 12.7 0.0 0.32 10.6 0.0 2.0 1 1 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase N terminal HIG_1_N PF04588.13 ADV19615.1 - 3.1e-06 27.3 1.1 5.5e-06 26.5 1.1 1.4 1 0 0 1 1 1 1 Hypoxia induced protein conserved region DUF4097 PF13349.6 ADV19616.1 - 0.0034 16.8 1.8 0.0061 15.9 1.8 1.4 1 0 0 1 1 1 1 Putative adhesin Gln-synt_N PF03951.19 ADV19617.1 - 9.1e-15 54.2 0.0 1.7e-14 53.3 0.0 1.4 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain Gln-synt_C PF00120.24 ADV19617.1 - 2.2e-14 53.2 0.0 4e-10 39.2 0.0 2.1 2 0 0 2 2 2 2 Glutamine synthetase, catalytic domain AMIN PF11741.8 ADV19617.1 - 0.17 12.1 0.0 0.29 11.3 0.0 1.3 1 0 0 1 1 1 0 AMIN domain ETF_QO PF05187.13 ADV19619.1 - 2e-40 137.1 0.1 3.2e-40 136.5 0.1 1.3 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S DAO PF01266.24 ADV19619.1 - 2.1e-07 30.9 2.5 0.00016 21.4 2.3 2.2 1 1 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 ADV19619.1 - 9e-07 29.0 0.1 2.5e-06 27.6 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 ADV19619.1 - 2.5e-05 23.5 0.6 0.0017 17.5 1.9 2.1 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 ADV19619.1 - 4.4e-05 22.9 0.0 8.1e-05 22.0 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 ADV19619.1 - 0.00017 21.0 0.2 0.00041 19.7 0.2 1.7 1 1 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 ADV19619.1 - 0.00047 19.5 0.0 0.0039 16.5 0.2 2.0 2 0 0 2 2 2 1 Thi4 family HI0933_like PF03486.14 ADV19619.1 - 0.00067 18.5 0.6 0.00095 18.0 0.6 1.2 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_3 PF13738.6 ADV19619.1 - 0.00079 18.8 0.6 0.0012 18.1 0.6 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 ADV19619.1 - 0.004 17.1 0.3 0.0081 16.2 0.3 1.5 1 0 0 1 1 1 1 FAD-NAD(P)-binding FAD_oxidored PF12831.7 ADV19619.1 - 0.014 14.7 0.5 0.023 14.1 0.5 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 ADV19619.1 - 0.016 14.3 0.4 0.028 13.5 0.4 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein Fer4_7 PF12838.7 ADV19619.1 - 0.03 14.9 0.9 0.076 13.6 0.9 1.7 1 0 0 1 1 1 0 4Fe-4S dicluster domain Pyr_redox PF00070.27 ADV19619.1 - 0.036 14.6 0.2 9 6.9 0.4 2.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 ADV19619.1 - 0.14 11.2 0.0 0.22 10.5 0.0 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A Fer4_2 PF12797.7 ADV19619.1 - 0.38 10.9 3.4 0.14 12.3 0.4 1.8 2 0 0 2 2 1 0 4Fe-4S binding domain Trp_halogenase PF04820.14 ADV19619.1 - 0.89 8.3 2.6 0.38 9.6 0.2 1.6 2 0 0 2 2 2 0 Tryptophan halogenase Fer4_6 PF12837.7 ADV19619.1 - 1.7 8.8 4.7 0.69 10.1 0.9 2.1 2 0 0 2 2 2 0 4Fe-4S binding domain MMS1_N PF10433.9 ADV19621.1 - 3.9e-140 467.7 0.0 5.5e-140 467.2 0.0 1.2 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 ADV19621.1 - 3.7e-92 309.1 0.0 6.7e-92 308.2 0.0 1.4 1 0 0 1 1 1 1 CPSF A subunit region Coiled-coil_56 PF09813.9 ADV19622.1 - 0.00065 19.7 0.0 0.00096 19.2 0.0 1.3 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 56 Erv26 PF04148.13 ADV19623.1 - 4.4e-68 229.2 2.8 7.3e-68 228.4 2.8 1.3 1 0 0 1 1 1 1 Transmembrane adaptor Erv26 Cyt-b5 PF00173.28 ADV19624.1 - 4.7e-10 39.5 0.0 8.1e-10 38.7 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain EMC3_TMCO1 PF01956.16 ADV19624.1 - 0.0024 17.6 0.0 0.0032 17.2 0.0 1.2 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like UcrQ PF02939.16 ADV19624.1 - 0.15 12.0 0.0 0.3 11.0 0.0 1.5 1 0 0 1 1 1 0 UcrQ family DUF4148 PF13663.6 ADV19625.1 - 0.074 13.2 0.0 0.094 12.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4148) R3H-assoc PF13902.6 ADV19627.1 - 0.023 15.1 3.3 0.023 15.1 3.3 2.2 1 1 1 2 2 2 0 R3H-associated N-terminal domain DUF4061 PF13270.6 ADV19627.1 - 0.14 12.5 2.7 0.14 12.5 1.6 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4061) Metaviral_G PF09595.10 ADV19627.1 - 0.76 9.8 5.6 0.81 9.7 0.5 2.2 2 0 0 2 2 2 0 Metaviral_G glycoprotein DUF883 PF05957.13 ADV19627.1 - 8.2 7.1 12.0 1.9 9.2 6.4 2.5 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF883) Iso_dh PF00180.20 ADV19629.1 - 2.8e-100 335.9 0.0 3.3e-100 335.6 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Actin PF00022.19 ADV19631.1 - 3e-149 497.1 0.0 1.5e-148 494.7 0.0 1.8 1 1 0 1 1 1 1 Actin GerD PF17898.1 ADV19631.1 - 0.076 13.0 0.0 0.2 11.6 0.0 1.7 1 0 0 1 1 1 0 Spore germination GerD central core domain Sdh5 PF03937.16 ADV19632.1 - 1.4e-25 89.0 0.3 2.1e-25 88.5 0.3 1.2 1 0 0 1 1 1 1 Flavinator of succinate dehydrogenase Fe-S_biosyn PF01521.20 ADV19634.1 - 2e-08 34.4 0.0 2.7e-08 34.0 0.0 1.2 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis Thiolase_N PF00108.23 ADV19636.1 - 9.5e-84 280.8 4.9 1.8e-83 279.9 3.6 1.9 2 0 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 ADV19636.1 - 1.6e-43 147.2 0.4 3.3e-43 146.2 0.4 1.5 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 ADV19636.1 - 0.0034 17.0 4.7 0.0043 16.7 0.3 3.0 3 1 0 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain SelA PF03841.13 ADV19636.1 - 0.036 13.1 0.1 0.063 12.3 0.1 1.3 1 0 0 1 1 1 0 L-seryl-tRNA selenium transferase ACP_syn_III_C PF08541.10 ADV19636.1 - 0.045 13.9 0.0 0.26 11.5 0.0 2.4 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal Lipase_GDSL PF00657.22 ADV19637.1 - 5.4e-10 39.6 0.0 1e-09 38.7 0.0 1.5 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 ADV19637.1 - 5.5e-10 39.9 0.0 1.6e-07 31.9 0.0 2.2 2 0 0 2 2 2 2 GDSL-like Lipase/Acylhydrolase family 2-oxoacid_dh PF00198.23 ADV19639.1 - 5.3e-68 229.0 0.0 7.1e-68 228.5 0.0 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 ADV19639.1 - 1.1e-18 66.8 2.9 2e-18 66.0 0.5 2.3 2 0 0 2 2 2 1 Biotin-requiring enzyme E3_binding PF02817.17 ADV19639.1 - 2.3e-13 50.2 0.7 4.6e-13 49.3 0.7 1.5 1 0 0 1 1 1 1 e3 binding domain Biotin_lipoyl_2 PF13533.6 ADV19639.1 - 0.00082 19.2 0.3 0.098 12.5 0.1 2.6 1 1 1 2 2 2 1 Biotin-lipoyl like HlyD_D23 PF16576.5 ADV19639.1 - 0.059 12.6 0.0 0.12 11.5 0.0 1.5 1 0 0 1 1 1 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion VWA_2 PF13519.6 ADV19640.1 - 3e-21 76.1 0.1 1.1e-20 74.3 0.1 1.9 2 0 0 2 2 2 1 von Willebrand factor type A domain UIM PF02809.20 ADV19640.1 - 3.6e-13 48.4 13.9 0.00027 20.7 0.9 3.7 3 0 0 3 3 3 3 Ubiquitin interaction motif VWA PF00092.28 ADV19640.1 - 1.3e-07 32.0 0.0 2e-07 31.4 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain Ssl1 PF04056.14 ADV19640.1 - 5.7e-06 26.3 0.0 8.4e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 Ssl1-like RAP80_UIM PF18282.1 ADV19640.1 - 0.0074 16.0 12.4 1.3 8.9 0.0 3.5 2 1 1 3 3 3 2 RAP80 N-terminal ubiquitin interaction motif RRM_1 PF00076.22 ADV19642.1 - 6.8e-41 137.9 0.0 6.9e-21 73.8 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ADV19642.1 - 0.00026 20.8 0.0 0.054 13.4 0.0 2.3 2 0 0 2 2 2 2 Occluded RNA-recognition motif RRM_7 PF16367.5 ADV19642.1 - 0.00064 19.8 0.0 1.6 8.9 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif Limkain-b1 PF11608.8 ADV19642.1 - 0.031 14.3 0.3 0.11 12.6 0.0 2.0 2 0 0 2 2 2 0 Limkain b1 RRM_5 PF13893.6 ADV19642.1 - 0.15 11.6 0.0 0.33 10.6 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SEEEED PF14797.6 ADV19642.1 - 5 7.3 76.5 4.3 7.5 43.2 2.7 2 0 0 2 2 2 0 Serine-rich region of AP3B1, clathrin-adaptor complex Keratin_2_head PF16208.5 ADV19642.1 - 6.8 6.8 27.6 14 5.7 27.6 1.6 1 0 0 1 1 1 0 Keratin type II head TFIIF_alpha PF05793.12 ADV19642.1 - 6.9 5.1 55.8 12 4.3 55.8 1.4 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) 4HBT_2 PF13279.6 ADV19643.1 - 1.4e-13 51.4 0.0 2.3e-13 50.7 0.0 1.3 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl-ACP_TE PF01643.17 ADV19643.1 - 2.1e-06 27.2 0.6 0.00051 19.4 0.1 2.2 2 0 0 2 2 2 2 Acyl-ACP thioesterase 4HBT PF03061.22 ADV19643.1 - 3.1e-05 24.2 0.0 5.2e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Thioesterase superfamily DUF1996 PF09362.10 ADV19644.1 - 4.1e-78 262.6 3.8 7.3e-78 261.8 3.8 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) WSC PF01822.19 ADV19644.1 - 1.3e-53 179.2 54.8 1.3e-19 70.2 14.4 3.7 3 0 0 3 3 3 3 WSC domain DAD PF02109.16 ADV19645.1 - 1.9e-39 134.4 0.8 2.1e-39 134.2 0.8 1.0 1 0 0 1 1 1 1 DAD family DUF1681 PF07933.14 ADV19646.1 - 2e-54 183.3 0.0 2.3e-54 183.1 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1681) Snf7 PF03357.21 ADV19648.1 - 2e-12 47.1 11.4 2.6e-12 46.7 11.4 1.2 1 0 0 1 1 1 1 Snf7 Ist1 PF03398.14 ADV19648.1 - 0.00022 21.2 2.7 0.00034 20.6 2.7 1.2 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway DMSP_lyase PF16867.5 ADV19648.1 - 0.049 13.3 0.2 0.13 11.9 0.0 1.7 2 0 0 2 2 2 0 Dimethlysulfonioproprionate lyase PRKCSH-like PF12999.7 ADV19649.1 - 3.9e-48 163.6 4.1 1.3e-47 161.8 4.1 1.9 1 0 0 1 1 1 1 Glucosidase II beta subunit-like PRKCSH_1 PF13015.6 ADV19649.1 - 2.4e-32 111.7 0.2 7.3e-32 110.2 0.2 1.8 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein PRKCSH PF07915.13 ADV19649.1 - 5.7e-10 40.1 3.1 5.7e-10 40.1 3.1 2.6 3 1 0 3 3 3 1 Glucosidase II beta subunit-like protein Ldl_recept_a PF00057.18 ADV19649.1 - 1.4 9.2 16.9 0.13 12.5 2.4 2.9 1 1 1 2 2 2 0 Low-density lipoprotein receptor domain class A DUF1640 PF07798.11 ADV19649.1 - 8.2 6.4 11.7 26 4.8 7.6 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF1640) DUF4407 PF14362.6 ADV19649.1 - 9.9 5.4 17.4 49 3.1 0.0 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4407) HLH PF00010.26 ADV19650.1 - 1.3e-14 53.9 1.1 1.3e-14 53.9 1.1 2.0 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain PRCC PF10253.9 ADV19651.1 - 7e-20 72.7 0.3 7e-20 72.7 0.3 2.5 1 1 1 2 2 2 1 Mitotic checkpoint regulator, MAD2B-interacting UCH PF00443.29 ADV19652.1 - 3.9e-43 147.8 0.1 6.4e-43 147.1 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ADV19652.1 - 3.8e-23 82.6 0.3 3.6e-22 79.4 0.3 2.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase NOB1_Zn_bind PF08772.11 ADV19653.1 - 2e-31 107.9 2.0 4.1e-31 107.0 2.0 1.5 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like PIN_6 PF17146.4 ADV19653.1 - 1.4e-26 92.8 0.4 4.7e-26 91.1 0.0 2.1 3 0 0 3 3 3 1 PIN domain of ribonuclease DZR PF12773.7 ADV19653.1 - 0.068 13.2 2.4 0.086 12.9 1.0 1.8 2 0 0 2 2 2 0 Double zinc ribbon zf-NADH-PPase PF09297.11 ADV19653.1 - 0.19 11.5 3.4 0.63 9.8 0.4 2.8 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain Jak1_Phl PF17887.1 ADV19653.1 - 2.8 7.9 6.7 0.54 10.2 0.8 2.3 2 0 0 2 2 2 0 Jak1 pleckstrin homology-like domain CPSF100_C PF13299.6 ADV19653.1 - 8.1 6.6 9.8 9.8 6.3 0.4 2.4 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Cpn60_TCP1 PF00118.24 ADV19655.1 - 1.2e-142 476.0 14.0 1.3e-142 475.9 14.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family CRM1_repeat PF18777.1 ADV19655.1 - 0.12 11.9 0.0 0.26 10.8 0.0 1.5 1 0 0 1 1 1 0 Chromosome region maintenance or exportin repeat MFS_1 PF07690.16 ADV19656.1 - 2.1e-26 92.7 45.8 2.4e-25 89.2 19.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ADV19656.1 - 2.9e-10 39.6 8.3 2.9e-10 39.6 8.3 2.8 2 1 1 3 3 3 1 Sugar (and other) transporter Mg-por_mtran_C PF07109.11 ADV19656.1 - 0.014 15.7 0.1 0.037 14.4 0.0 1.7 2 0 0 2 2 2 0 Magnesium-protoporphyrin IX methyltransferase C-terminus IMPDH PF00478.25 ADV19657.1 - 2.2e-134 447.8 0.8 2.6e-134 447.6 0.8 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.28 ADV19657.1 - 1.2e-12 48.0 0.0 4.8e-06 26.9 0.0 2.5 2 0 0 2 2 2 2 CBS domain NMO PF03060.15 ADV19657.1 - 1.8e-08 34.2 8.5 0.0002 20.9 8.2 2.7 2 1 1 3 3 3 2 Nitronate monooxygenase FMN_dh PF01070.18 ADV19657.1 - 2.9e-08 33.1 0.5 4.8e-08 32.4 0.5 1.3 1 0 0 1 1 1 1 FMN-dependent dehydrogenase His_biosynth PF00977.21 ADV19657.1 - 7e-07 28.9 2.7 6.6e-06 25.7 2.7 2.3 2 1 0 2 2 2 1 Histidine biosynthesis protein ThiG PF05690.14 ADV19657.1 - 0.00024 20.5 0.8 0.00056 19.3 0.8 1.6 1 0 0 1 1 1 1 Thiazole biosynthesis protein ThiG TMP-TENI PF02581.17 ADV19657.1 - 0.14 11.5 2.6 2.9 7.2 0.1 2.5 2 0 0 2 2 2 0 Thiamine monophosphate synthase Formyl_trans_C PF02911.18 ADV19657.1 - 0.15 12.3 0.0 5.1 7.4 0.0 2.4 2 0 0 2 2 2 0 Formyl transferase, C-terminal domain G3P_antiterm PF04309.12 ADV19657.1 - 0.15 11.4 0.8 5.5 6.4 0.1 2.3 2 0 0 2 2 2 0 Glycerol-3-phosphate responsive antiterminator YpsA PF06908.11 ADV19657.1 - 0.17 11.8 0.0 0.31 11.0 0.0 1.3 1 0 0 1 1 1 0 YspA SLOG family PcrB PF01884.17 ADV19657.1 - 0.52 9.7 3.5 1.7 8.1 0.0 3.0 4 0 0 4 4 4 0 PcrB family Importin_rep_3 PF18806.1 ADV19658.1 - 3.4e-05 23.8 0.1 0.0005 20.1 0.0 3.1 3 0 0 3 3 3 1 Importin 13 repeat Xpo1 PF08389.12 ADV19658.1 - 0.0023 18.0 1.0 0.023 14.8 0.0 3.2 4 1 0 4 4 4 1 Exportin 1-like protein IBN_N PF03810.19 ADV19658.1 - 0.0048 16.8 0.0 0.012 15.5 0.0 1.7 1 0 0 1 1 1 1 Importin-beta N-terminal domain SEN1_N PF12726.7 ADV19658.1 - 0.18 10.0 0.0 0.31 9.2 0.0 1.3 1 0 0 1 1 1 0 SEN1 N terminal zf-ANAPC11 PF12861.7 ADV19659.1 - 9.2e-30 102.6 12.6 3.7e-17 62.2 2.8 2.2 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 ADV19659.1 - 7.9e-16 58.1 17.1 1.3e-13 51.0 17.1 2.3 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 ADV19659.1 - 6.8e-06 26.3 5.4 6.8e-06 26.3 5.4 2.5 2 1 0 2 2 2 1 Ring finger domain Zn_ribbon_17 PF17120.5 ADV19659.1 - 0.0034 17.0 8.9 0.0034 17.0 8.9 2.1 1 1 1 2 2 2 1 Zinc-ribbon, C4HC2 type Zf_RING PF16744.5 ADV19659.1 - 0.014 15.5 2.1 0.014 15.5 2.1 2.2 1 1 1 2 2 2 0 KIAA1045 RING finger zf-Nse PF11789.8 ADV19659.1 - 0.069 13.0 3.9 0.11 12.3 2.8 1.9 1 1 1 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.6 ADV19659.1 - 0.73 9.9 13.1 5.5 7.1 13.1 2.2 1 1 0 1 1 1 0 RING-type zinc-finger zf-C3HC4 PF00097.25 ADV19659.1 - 1 9.3 16.2 15 5.6 16.2 2.6 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-HIT PF04438.16 ADV19659.1 - 1.7 8.6 11.7 7.4 6.5 11.7 2.3 1 1 0 1 1 1 0 HIT zinc finger zf-C3HC4_2 PF13923.6 ADV19659.1 - 7.8 6.4 21.7 0.19 11.6 9.4 3.1 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DHHC PF01529.20 ADV19660.1 - 6.3e-31 107.3 6.3 6.3e-31 107.3 6.3 2.3 2 0 0 2 2 2 1 DHHC palmitoyltransferase Ank PF00023.30 ADV19660.1 - 5.3e-27 93.0 6.3 2.5e-06 27.7 0.1 5.0 4 0 0 4 4 4 4 Ankyrin repeat Ank_2 PF12796.7 ADV19660.1 - 2.9e-25 88.7 0.5 9.8e-12 45.3 0.0 3.2 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ADV19660.1 - 2.4e-20 72.3 2.4 3.6e-08 33.5 0.0 4.7 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 ADV19660.1 - 2.8e-20 72.4 3.2 4.4e-07 30.3 0.1 4.2 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 ADV19660.1 - 4e-19 66.7 1.9 0.0025 18.2 0.0 5.4 5 0 0 5 5 5 4 Ankyrin repeat MerC PF03203.14 ADV19660.1 - 9.8 6.7 11.1 0.24 11.9 0.6 2.6 2 1 0 2 2 2 0 MerC mercury resistance protein Ank_5 PF13857.6 ADV19661.1 - 1.5e-05 25.2 0.0 3e-05 24.2 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 ADV19661.1 - 0.00013 22.5 0.0 0.00068 20.2 0.0 2.0 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.30 ADV19661.1 - 0.00025 21.4 0.0 0.00056 20.2 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeat Ank_4 PF13637.6 ADV19661.1 - 0.00071 20.1 0.0 0.0026 18.3 0.0 1.9 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 ADV19661.1 - 0.02 15.4 0.0 0.086 13.4 0.0 2.2 1 0 0 1 1 1 0 Ankyrin repeat MFS_1 PF07690.16 ADV19662.1 - 1.2e-31 109.9 51.5 6.7e-23 81.2 22.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily ABC1 PF03109.16 ADV19663.1 - 1.4e-22 80.1 0.0 4.2e-22 78.6 0.0 1.9 1 1 0 1 1 1 1 ABC1 family DUF1992 PF09350.10 ADV19663.1 - 1.3e-15 57.3 0.1 4.7e-15 55.5 0.1 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1992) APH PF01636.23 ADV19663.1 - 0.059 13.3 0.0 0.14 12.0 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family Dus PF01207.17 ADV19664.1 - 2e-67 227.5 0.3 6.5e-65 219.2 0.0 2.5 2 1 0 2 2 2 2 Dihydrouridine synthase (Dus) NMO PF03060.15 ADV19664.1 - 0.00096 18.6 0.0 0.021 14.2 0.0 2.2 1 1 1 2 2 2 1 Nitronate monooxygenase ThiG PF05690.14 ADV19664.1 - 0.0045 16.3 0.0 0.0077 15.6 0.0 1.3 1 0 0 1 1 1 1 Thiazole biosynthesis protein ThiG PP2C PF00481.21 ADV19665.1 - 3.6e-30 105.5 0.0 4.1e-29 102.0 0.0 2.1 1 1 0 1 1 1 1 Protein phosphatase 2C TPR_1 PF00515.28 ADV19666.1 - 1.2e-05 24.9 0.0 0.0052 16.6 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 ADV19666.1 - 9.7e-05 22.2 0.0 0.019 15.1 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat UBA PF00627.31 ADV19666.1 - 0.00013 21.8 0.0 0.00036 20.4 0.0 1.8 1 0 0 1 1 1 1 UBA/TS-N domain DnaJ PF00226.31 ADV19666.1 - 0.00035 20.6 0.0 0.0012 19.0 0.0 1.8 1 0 0 1 1 1 1 DnaJ domain TPR_12 PF13424.6 ADV19666.1 - 0.11 12.7 2.2 0.65 10.3 0.1 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.6 ADV19666.1 - 0.12 13.0 0.0 0.12 13.0 0.0 5.1 6 0 0 6 6 6 0 Tetratricopeptide repeat Spc24 PF08286.11 ADV19667.1 - 4.1e-18 65.5 5.0 9.1e-18 64.4 1.2 2.2 2 0 0 2 2 2 1 Spc24 subunit of Ndc80 Prefoldin PF02996.17 ADV19667.1 - 0.053 13.4 2.6 0.34 10.8 0.4 2.3 2 0 0 2 2 2 0 Prefoldin subunit CEP209_CC5 PF16574.5 ADV19667.1 - 0.09 12.9 4.1 0.2 11.8 2.5 2.0 1 1 1 2 2 2 0 Coiled-coil region of centrosome protein CE290 End3 PF12761.7 ADV19667.1 - 0.11 12.6 3.9 0.17 12.1 3.9 1.3 1 0 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 Enkurin PF13864.6 ADV19667.1 - 0.13 12.7 3.2 0.08 13.4 1.3 1.7 1 1 0 1 1 1 0 Calmodulin-binding Spc7 PF08317.11 ADV19667.1 - 0.46 9.3 6.5 0.66 8.8 6.5 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Snf7 PF03357.21 ADV19668.1 - 4.5e-34 117.5 19.0 5.7e-34 117.2 19.0 1.1 1 0 0 1 1 1 1 Snf7 T3SS_needle_E PF08988.10 ADV19668.1 - 0.43 10.8 5.7 1.1 9.5 1.2 2.5 2 0 0 2 2 2 0 Type III secretion system, cytoplasmic E component of needle LUC7 PF03194.15 ADV19668.1 - 0.44 10.2 10.3 0.082 12.6 6.5 1.6 1 1 0 2 2 2 0 LUC7 N_terminus Exonuc_VII_L PF02601.15 ADV19668.1 - 0.78 9.2 7.7 1 8.9 7.7 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Atg14 PF10186.9 ADV19668.1 - 1.8 7.6 9.3 2.3 7.2 9.3 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 S-AdoMet_synt_C PF02773.16 ADV19669.1 - 1.5e-67 225.8 0.4 5.5e-67 224.0 0.0 1.9 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.16 ADV19669.1 - 1.8e-47 160.5 0.0 3.1e-47 159.7 0.0 1.4 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.20 ADV19669.1 - 2.2e-45 153.4 1.1 3.4e-45 152.8 0.2 1.8 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, N-terminal domain AdoMet_Synthase PF01941.19 ADV19669.1 - 0.03 13.1 0.1 0.15 10.8 0.0 2.0 2 0 0 2 2 2 0 S-adenosylmethionine synthetase (AdoMet synthetase) EF1G PF00647.19 ADV19670.1 - 1.2e-43 147.5 0.1 2.1e-43 146.7 0.1 1.4 1 0 0 1 1 1 1 Elongation factor 1 gamma, conserved domain GST_C PF00043.25 ADV19670.1 - 8.7e-11 41.9 0.0 8.7e-11 41.9 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 ADV19670.1 - 2.2e-09 37.5 0.0 6.6e-09 36.0 0.0 1.9 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 ADV19670.1 - 5.3e-09 36.2 0.0 1.6e-08 34.6 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 ADV19670.1 - 2e-08 34.4 0.0 4.8e-08 33.2 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 ADV19670.1 - 2.9e-06 27.6 0.0 5.6e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 ADV19670.1 - 0.00011 22.2 0.0 0.00031 20.7 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 ADV19670.1 - 0.00051 19.8 0.0 0.0022 17.8 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain Ribosomal_60s PF00428.19 ADV19670.1 - 0.078 13.6 6.5 0.25 11.9 6.5 1.9 1 0 0 1 1 1 0 60s Acidic ribosomal protein GST_N_4 PF17172.4 ADV19670.1 - 0.14 13.0 0.0 0.46 11.3 0.0 1.9 2 0 0 2 2 2 0 Glutathione S-transferase N-terminal domain WD40 PF00400.32 ADV19671.1 - 1.5e-13 50.9 19.7 0.033 15.1 0.1 8.3 7 2 0 7 7 7 5 WD domain, G-beta repeat F-box PF00646.33 ADV19671.1 - 8.2e-10 38.3 2.6 8.2e-10 38.3 2.6 1.8 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 ADV19671.1 - 1.2e-08 34.7 2.5 2.7e-08 33.6 2.5 1.7 1 0 0 1 1 1 1 F-box-like Nup160 PF11715.8 ADV19671.1 - 8.4e-05 21.4 0.0 0.0058 15.3 0.0 2.4 2 0 0 2 2 2 2 Nucleoporin Nup120/160 Ofd1_CTDD PF10637.9 ADV19672.1 - 2.2e-66 223.8 0.0 1.8e-62 211.0 0.0 2.1 2 0 0 2 2 2 2 Oxoglutarate and iron-dependent oxygenase degradation C-term 2OG-FeII_Oxy_4 PF13661.6 ADV19672.1 - 1.6e-20 73.5 0.0 4.4e-20 72.2 0.0 1.7 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.6 ADV19672.1 - 2.6e-09 37.9 0.2 7.9e-08 33.1 0.2 2.4 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF2433 PF10360.9 ADV19674.1 - 8.3e-28 97.0 0.5 3e-26 91.9 0.5 2.4 1 1 0 1 1 1 1 Protein of unknown function (DUF2433) RRM_1 PF00076.22 ADV19674.1 - 4.8e-10 39.1 0.1 2.3e-09 36.9 0.1 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Metallophos PF00149.28 ADV19674.1 - 0.016 15.7 0.0 0.027 15.0 0.0 1.5 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase Metallophos PF00149.28 ADV19675.1 - 1.5e-36 126.8 0.2 2e-36 126.4 0.2 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 ADV19675.1 - 0.045 14.2 0.2 0.097 13.1 0.2 1.6 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain Glyco_hydro_65N PF03636.15 ADV19675.1 - 0.064 12.9 0.0 0.095 12.3 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain Metallophos_2 PF12850.7 ADV19675.1 - 0.14 12.3 0.0 0.25 11.5 0.0 1.4 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain Glyoxal_oxid_N PF07250.11 ADV19676.1 - 1.1e-32 113.1 0.2 6.2e-27 94.3 0.0 3.4 3 1 0 3 3 3 2 Glyoxal oxidase N-terminus DUF1929 PF09118.11 ADV19676.1 - 2.9e-24 85.2 0.3 7e-24 83.9 0.3 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1929) Mss4 PF04421.13 ADV19677.1 - 4.5e-13 49.1 0.0 6.4e-13 48.6 0.0 1.2 1 0 0 1 1 1 1 Mss4 protein DUF5102 PF17104.5 ADV19678.1 - 1.3e-31 110.8 0.0 1.3e-31 110.8 0.0 2.6 2 1 1 3 3 3 1 Domain of unknown function (DUF5102) DSPn PF14671.6 ADV19679.1 - 7.8e-30 104.2 0.0 7.6e-28 97.7 0.0 2.3 2 0 0 2 2 2 1 Dual specificity protein phosphatase, N-terminal half DSPc PF00782.20 ADV19679.1 - 2.9e-15 56.2 0.0 6.5e-15 55.1 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ADV19679.1 - 6.8e-06 25.8 0.0 1.3e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 ADV19679.1 - 0.0055 16.8 0.0 0.012 15.7 0.0 1.5 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 ADV19679.1 - 0.053 13.5 0.0 0.092 12.7 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family Y_phosphatase2 PF03162.13 ADV19679.1 - 0.058 13.0 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family PP2C PF00481.21 ADV19680.1 - 7.5e-66 222.4 0.1 6e-53 180.1 0.1 2.1 2 0 0 2 2 2 2 Protein phosphatase 2C Gp49 PF05973.14 ADV19680.1 - 0.13 12.4 0.0 0.24 11.6 0.0 1.4 1 0 0 1 1 1 0 Phage derived protein Gp49-like (DUF891) Ribosomal_L35p PF01632.19 ADV19682.1 - 2e-14 53.8 1.7 2.9e-14 53.3 1.7 1.2 1 0 0 1 1 1 1 Ribosomal protein L35 Pro_isomerase PF00160.21 ADV19683.1 - 1.7e-39 135.7 0.0 2.6e-39 135.0 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_1 PF00076.22 ADV19683.1 - 1.3e-14 53.8 0.0 2.1e-14 53.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Zn_clus PF00172.18 ADV19684.1 - 4.4e-08 33.1 12.1 7.7e-08 32.3 12.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Rep_fac-A_C PF08646.10 ADV19684.1 - 0.092 12.5 2.4 0.16 11.7 2.4 1.3 1 0 0 1 1 1 0 Replication factor-A C terminal domain CENP-F_N PF10481.9 ADV19684.1 - 0.17 11.5 0.9 0.25 11.0 0.9 1.1 1 0 0 1 1 1 0 Cenp-F N-terminal domain RuBisCO_large PF00016.20 ADV19685.1 - 0.036 13.3 0.1 0.05 12.8 0.1 1.2 1 0 0 1 1 1 0 Ribulose bisphosphate carboxylase large chain, catalytic domain Prefoldin_2 PF01920.20 ADV19686.1 - 5.8e-21 74.4 0.1 6.7e-21 74.2 0.1 1.0 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin PF02996.17 ADV19686.1 - 0.0016 18.4 0.5 0.0071 16.3 0.0 1.9 1 1 1 2 2 2 1 Prefoldin subunit Taxilin PF09728.9 ADV19686.1 - 0.0091 15.2 0.6 1.8 7.7 0.1 2.0 2 0 0 2 2 2 2 Myosin-like coiled-coil protein Phage_Mu_Gam PF07352.12 ADV19686.1 - 0.034 14.1 0.1 0.045 13.7 0.1 1.3 1 0 0 1 1 1 0 Bacteriophage Mu Gam like protein APG6_N PF17675.1 ADV19686.1 - 0.034 14.7 0.2 0.049 14.2 0.2 1.2 1 0 0 1 1 1 0 Apg6 coiled-coil region OmpH PF03938.14 ADV19686.1 - 0.045 14.1 0.4 9.5 6.6 0.1 2.1 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) DUF148 PF02520.17 ADV19686.1 - 0.053 13.6 0.1 0.34 11.0 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function DUF148 TPR_MLP1_2 PF07926.12 ADV19686.1 - 0.07 13.2 1.8 1.2 9.2 0.2 2.0 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein FlaC_arch PF05377.11 ADV19686.1 - 0.15 12.5 0.6 1.9 8.9 0.0 2.4 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DLL_N PF12413.8 ADV19688.1 - 0.14 13.4 0.1 0.51 11.6 0.0 1.8 2 0 0 2 2 2 0 Homeobox protein distal-less-like N terminal Nop53 PF07767.11 ADV19689.1 - 5.3e-91 306.0 34.7 6.5e-91 305.7 34.7 1.1 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) Mt_ATP-synt_B PF05405.14 ADV19689.1 - 2.1 7.9 14.4 0.86 9.2 11.0 2.0 2 0 0 2 2 2 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) HD PF01966.22 ADV19689.1 - 3.2 8.0 5.6 2.1 8.6 0.0 2.7 2 1 0 2 2 2 0 HD domain MDM10 PF12519.8 ADV19689.1 - 3.9 6.2 9.4 7.2 5.4 9.4 1.5 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 WD40 PF00400.32 ADV19691.1 - 2.5e-13 50.3 15.5 0.00041 21.1 0.5 6.5 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV19691.1 - 2.6e-05 24.4 1.1 0.024 14.9 0.2 3.9 1 1 4 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ADV19691.1 - 0.0026 16.8 0.4 0.13 11.2 0.0 2.6 2 1 0 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein MccV PF17508.2 ADV19691.1 - 0.038 14.5 0.1 0.1 13.1 0.1 1.7 1 0 0 1 1 1 0 Microcin V bacteriocin DUF5419 PF17441.2 ADV19691.1 - 0.081 13.0 0.1 0.17 12.0 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5419) Pyr_redox_2 PF07992.14 ADV19692.1 - 0.00028 20.2 0.0 0.023 14.0 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FA_hydroxylase PF04116.13 ADV19693.1 - 8.9e-24 84.3 25.5 3.5e-23 82.4 21.7 2.3 2 1 0 2 2 2 2 Fatty acid hydroxylase superfamily zf-CCHC PF00098.23 ADV19694.1 - 2.2e-18 65.4 24.8 8.1e-07 28.8 1.5 3.3 3 0 0 3 3 3 3 Zinc knuckle zf-CCHC_2 PF13696.6 ADV19694.1 - 0.00096 18.9 21.5 0.079 12.8 0.6 3.4 3 0 0 3 3 3 3 Zinc knuckle zf-CCHC_3 PF13917.6 ADV19694.1 - 0.099 12.6 15.4 0.85 9.6 1.1 3.3 2 1 1 3 3 3 0 Zinc knuckle zf-CCHC_5 PF14787.6 ADV19694.1 - 0.25 11.1 17.3 0.91 9.3 0.9 3.6 3 0 0 3 3 3 0 GAG-polyprotein viral zinc-finger C2 PF00168.30 ADV19695.1 - 8.6e-23 80.6 0.0 2.9e-14 53.2 0.0 2.5 2 0 0 2 2 2 2 C2 domain Thiolase_N PF00108.23 ADV19696.1 - 6.2e-71 238.8 0.0 9.6e-71 238.2 0.0 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 ADV19696.1 - 4.2e-44 149.1 0.3 1.1e-43 147.8 0.3 1.7 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 ADV19696.1 - 3.2e-05 23.6 0.1 6.4e-05 22.7 0.1 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain DLIC PF05783.11 ADV19697.1 - 2.4e-39 135.5 0.0 1.1e-24 87.1 0.0 4.4 3 1 1 4 4 4 4 Dynein light intermediate chain (DLIC) WD40 PF00400.32 ADV19698.1 - 9.6e-14 51.6 9.2 0.0011 19.7 0.5 5.7 5 1 0 5 5 5 4 WD domain, G-beta repeat SLAC1 PF03595.17 ADV19699.1 - 7.9e-72 242.2 42.2 9e-72 242.1 42.2 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel PAP2_C PF14360.6 ADV19699.1 - 0.035 14.6 2.5 0.035 14.6 2.5 4.0 5 0 0 5 5 5 0 PAP2 superfamily C-terminal NIF PF03031.18 ADV19700.1 - 1.1e-37 129.2 0.0 2e-37 128.3 0.0 1.4 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase DUF2076 PF09849.9 ADV19700.1 - 0.01 15.9 0.5 0.01 15.9 0.5 2.3 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) UCR_Fe-S_N PF10399.9 ADV19700.1 - 0.1 12.0 0.2 0.21 11.0 0.2 1.5 1 0 0 1 1 1 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal Ribosomal_L16 PF00252.18 ADV19701.1 - 5.2e-41 139.7 0.1 6.6e-41 139.4 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e Carn_acyltransf PF00755.20 ADV19702.1 - 3.3e-180 600.6 0.0 3.8e-180 600.4 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase SP2 PF03014.14 ADV19702.1 - 0.23 9.8 0.6 0.33 9.3 0.6 1.1 1 0 0 1 1 1 0 Structural protein 2 TPMT PF05724.11 ADV19703.1 - 2.1e-39 135.4 0.0 2.5e-39 135.2 0.0 1.1 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_11 PF08241.12 ADV19703.1 - 1.9e-07 31.6 0.0 2.9e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ADV19703.1 - 2e-06 28.4 0.0 3.1e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ADV19703.1 - 2.9e-05 23.9 0.0 4.1e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ADV19703.1 - 0.0001 22.2 0.0 0.00019 21.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ADV19703.1 - 0.00023 21.9 0.0 0.00034 21.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain AdoMet_MTase PF07757.13 ADV19703.1 - 0.048 14.0 0.0 0.092 13.1 0.0 1.4 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase TehB PF03848.14 ADV19703.1 - 0.18 11.2 0.0 0.19 11.1 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TehB N2227 PF07942.12 ADV19703.1 - 0.23 10.6 0.0 0.43 9.7 0.0 1.4 1 0 0 1 1 1 0 N2227-like protein Chitin_synth_2 PF03142.15 ADV19704.1 - 8.8e-232 770.4 0.1 1.2e-231 770.0 0.1 1.1 1 0 0 1 1 1 1 Chitin synthase Cyt-b5 PF00173.28 ADV19704.1 - 4.8e-22 77.9 2.3 2e-14 53.5 0.1 3.3 2 1 0 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain Glyco_tranf_2_3 PF13641.6 ADV19704.1 - 1e-11 45.2 0.0 5.5e-11 42.8 0.0 2.0 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 ADV19704.1 - 9e-11 42.1 1.4 9e-11 42.1 1.4 2.3 2 1 0 2 2 2 1 Glycosyl transferase family group 2 DEK_C PF08766.11 ADV19704.1 - 3.8e-10 39.5 0.0 2e-09 37.2 0.0 2.1 2 0 0 2 2 2 1 DEK C terminal domain Glycos_transf_2 PF00535.26 ADV19704.1 - 7.1e-06 25.9 0.0 0.008 16.0 0.0 2.6 2 0 0 2 2 2 2 Glycosyl transferase family 2 Jiv90 PF14901.6 ADV19704.1 - 0.0079 16.3 2.1 0.15 12.2 0.1 2.6 2 0 0 2 2 2 1 Cleavage inducing molecular chaperone Glyco_transf_21 PF13506.6 ADV19704.1 - 0.018 14.5 0.0 0.14 11.7 0.0 2.1 2 0 0 2 2 2 0 Glycosyl transferase family 21 Abhydro_lipase PF04083.16 ADV19707.1 - 1.1e-16 60.1 0.0 2.3e-16 59.1 0.0 1.5 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.20 ADV19707.1 - 8.4e-07 28.9 0.1 1.4e-06 28.1 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ADV19707.1 - 0.00023 20.5 0.0 0.00089 18.6 0.0 1.8 2 0 0 2 2 2 1 Serine aminopeptidase, S33 DUF1749 PF08538.10 ADV19708.1 - 2e-103 345.6 0.0 2.3e-103 345.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1749) DUF900 PF05990.12 ADV19708.1 - 2.4e-05 24.0 0.0 3.1e-05 23.6 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) Hydrolase_4 PF12146.8 ADV19708.1 - 0.0013 18.0 0.0 0.0032 16.8 0.0 1.6 2 0 0 2 2 2 1 Serine aminopeptidase, S33 DUF915 PF06028.11 ADV19708.1 - 0.016 14.5 0.2 0.024 14.0 0.2 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) Peptidase_S9 PF00326.21 ADV19708.1 - 0.022 14.3 0.0 3.5 7.0 0.0 2.3 2 0 0 2 2 2 0 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 ADV19708.1 - 0.066 12.8 0.2 0.14 11.8 0.1 1.5 2 0 0 2 2 2 0 alpha/beta hydrolase fold DUF3530 PF12048.8 ADV19708.1 - 0.13 11.7 0.0 0.2 11.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) DUF1057 PF06342.12 ADV19708.1 - 0.13 11.2 0.0 0.18 10.8 0.0 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) DUF3089 PF11288.8 ADV19708.1 - 0.14 11.7 0.0 0.2 11.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) 5-FTHF_cyc-lig PF01812.20 ADV19709.1 - 3.6e-31 108.5 0.0 4.2e-31 108.2 0.0 1.1 1 0 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family Ricin_B_lectin PF00652.22 ADV19710.1 - 1.6e-18 67.1 6.0 1.8e-11 44.4 1.5 1.8 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain RicinB_lectin_2 PF14200.6 ADV19710.1 - 3.7e-05 24.4 8.5 0.018 15.8 0.9 2.3 1 1 0 2 2 2 2 Ricin-type beta-trefoil lectin domain-like DUF1505 PF07403.11 ADV19710.1 - 0.0055 16.9 0.1 0.11 12.7 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1505) Ricin_B_lectin PF00652.22 ADV19711.1 - 4.4e-11 43.1 1.5 7.9e-11 42.3 1.5 1.4 1 1 0 1 1 1 1 Ricin-type beta-trefoil lectin domain RicinB_lectin_2 PF14200.6 ADV19711.1 - 0.00015 22.4 1.8 0.00043 20.9 0.7 2.1 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain-like Nop25 PF09805.9 ADV19712.1 - 0.016 15.7 12.6 0.016 15.7 12.6 2.7 2 1 0 2 2 2 0 Nucleolar protein 12 (25kDa) zf-C2H2_jaz PF12171.8 ADV19712.1 - 0.032 14.5 0.1 0.054 13.8 0.1 1.3 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding DUF202 PF02656.15 ADV19715.1 - 1.7e-15 57.2 1.6 2.3e-15 56.8 1.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF202) Nipped-B_C PF12830.7 ADV19716.1 - 3e-39 134.9 0.8 9.2e-39 133.4 0.2 2.2 2 0 0 2 2 2 1 Sister chromatid cohesion C-terminus Cohesin_HEAT PF12765.7 ADV19716.1 - 5.6e-11 42.5 5.4 1.3e-10 41.4 0.3 3.2 3 0 0 3 3 3 1 HEAT repeat associated with sister chromatid cohesion Cnd1 PF12717.7 ADV19716.1 - 7e-06 26.2 0.3 0.00018 21.6 0.0 3.2 3 1 1 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 ADV19716.1 - 0.0065 16.6 0.0 2.8 8.4 0.0 3.6 3 0 0 3 3 3 1 HEAT repeat HEAT_EZ PF13513.6 ADV19716.1 - 0.09 13.3 0.2 4.1 8.0 0.1 3.1 2 0 0 2 2 2 0 HEAT-like repeat T2SSM PF04612.12 ADV19717.1 - 0.0068 16.5 0.0 0.0068 16.5 0.0 3.0 3 0 0 3 3 3 1 Type II secretion system (T2SS), protein M YabA PF06156.13 ADV19717.1 - 2 9.1 6.9 2.7 8.7 2.2 3.1 2 0 0 2 2 2 0 Initiation control protein YabA Profilin PF00235.19 ADV19720.1 - 5.1e-41 139.9 0.3 5.7e-41 139.8 0.3 1.0 1 0 0 1 1 1 1 Profilin Chorismate_bind PF00425.18 ADV19722.1 - 6.4e-91 304.5 0.0 1.3e-90 303.5 0.0 1.5 1 0 0 1 1 1 1 chorismate binding enzyme GATase PF00117.28 ADV19722.1 - 1.9e-29 102.8 0.0 2.8e-29 102.2 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 ADV19722.1 - 5.2e-07 29.6 0.0 9.9e-07 28.7 0.0 1.4 1 0 0 1 1 1 1 Peptidase C26 FAM176 PF14851.6 ADV19722.1 - 0.028 14.1 0.0 0.055 13.1 0.0 1.4 1 0 0 1 1 1 0 FAM176 family Anth_synt_I_N PF04715.13 ADV19722.1 - 0.056 13.7 0.0 1.4 9.1 0.0 2.3 2 0 0 2 2 2 0 Anthranilate synthase component I, N terminal region Chalcone_2 PF16035.5 ADV19723.1 - 3.6e-44 151.0 0.0 4.3e-44 150.7 0.0 1.1 1 0 0 1 1 1 1 Chalcone isomerase like Chalcone_3 PF16036.5 ADV19723.1 - 9.4e-09 35.6 0.0 0.0022 18.2 0.0 2.2 2 0 0 2 2 2 2 Chalcone isomerase-like Glyco_hydro_16 PF00722.21 ADV19726.1 - 5.4e-44 149.8 7.5 7.4e-44 149.3 7.5 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Chitin_bind_1 PF00187.19 ADV19726.1 - 0.0032 17.9 15.2 0.0069 16.8 15.2 1.5 1 0 0 1 1 1 1 Chitin recognition protein AA_permease PF00324.21 ADV19727.1 - 2.2e-114 382.7 38.6 2.4e-114 382.6 38.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 ADV19727.1 - 1.8e-31 109.5 40.3 2.2e-31 109.2 40.3 1.1 1 0 0 1 1 1 1 Amino acid permease DUF983 PF06170.12 ADV19727.1 - 0.41 11.1 5.3 2.1 8.8 1.2 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF983) PAP_central PF04928.17 ADV19728.1 - 9.7e-100 332.6 0.0 1.3e-99 332.2 0.0 1.2 1 0 0 1 1 1 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.15 ADV19728.1 - 8.2e-43 146.0 0.0 1.4e-42 145.2 0.0 1.4 1 0 0 1 1 1 1 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.23 ADV19728.1 - 9.1e-09 35.5 0.0 2.2e-08 34.2 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain zf-HIT PF04438.16 ADV19728.1 - 0.18 11.7 0.3 0.31 11.0 0.3 1.4 1 0 0 1 1 1 0 HIT zinc finger MutS_V PF00488.21 ADV19729.1 - 1.3e-44 152.5 0.1 2.2e-44 151.7 0.1 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 ADV19729.1 - 4.6e-26 92.2 0.1 3.3e-25 89.4 0.0 2.2 2 0 0 2 2 2 1 MutS domain III AAA_22 PF13401.6 ADV19729.1 - 0.012 15.9 0.0 0.043 14.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain RsbU_N PF08673.10 ADV19729.1 - 0.05 13.7 0.4 0.2 11.7 0.2 2.1 2 0 0 2 2 2 0 Phosphoserine phosphatase RsbU, N-terminal domain AAA_29 PF13555.6 ADV19729.1 - 0.12 12.1 0.3 0.38 10.5 0.3 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain RhoGEF PF00621.20 ADV19731.1 - 2.6e-10 40.8 0.0 6.4e-10 39.6 0.0 1.6 1 0 0 1 1 1 1 RhoGEF domain MFS_1 PF07690.16 ADV19734.1 - 2.6e-42 145.0 23.5 2.6e-42 145.0 23.5 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ADV19734.1 - 8e-13 48.0 4.2 8e-13 48.0 4.2 2.2 2 0 0 2 2 2 1 Sugar (and other) transporter OATP PF03137.20 ADV19734.1 - 0.0037 15.6 1.6 0.0066 14.8 1.6 1.4 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MWFE PF15879.5 ADV19735.1 - 5.5e-23 80.9 0.4 6.6e-23 80.6 0.4 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase MWFE subunit ATP19 PF11022.8 ADV19736.1 - 1.1e-21 76.9 0.3 1.3e-21 76.7 0.3 1.1 1 0 0 1 1 1 1 ATP synthase subunit K DUF2371 PF10177.9 ADV19736.1 - 0.093 12.9 0.0 0.1 12.8 0.0 1.0 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2371) DUF1275 PF06912.11 ADV19737.1 - 5.9e-26 91.6 13.7 6.9e-26 91.4 13.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1275) E1-E2_ATPase PF00122.20 ADV19738.1 - 1.7e-36 125.4 19.6 8.9e-36 123.1 12.4 3.6 3 1 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 ADV19738.1 - 3.4e-29 101.8 1.7 3.4e-29 101.8 1.7 2.4 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 ADV19738.1 - 6.9e-19 67.7 0.0 1.2e-18 67.0 0.0 1.4 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 ADV19738.1 - 2.2e-18 67.3 0.1 6.1e-17 62.6 0.1 2.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 ADV19738.1 - 1.9e-17 62.7 0.7 4.2e-17 61.6 0.0 2.0 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 ADV19738.1 - 0.00015 21.6 0.1 0.00023 21.0 0.1 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hexapep PF00132.24 ADV19739.1 - 6.9e-11 41.4 15.2 1.8e-06 27.5 3.1 3.8 2 2 2 4 4 4 4 Bacterial transferase hexapeptide (six repeats) W2 PF02020.18 ADV19739.1 - 1.6e-06 28.1 0.1 4.8e-06 26.6 0.1 1.8 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon Hexapep_2 PF14602.6 ADV19739.1 - 2.1e-05 24.1 15.9 0.0056 16.4 0.8 2.7 2 0 0 2 2 2 2 Hexapeptide repeat of succinyl-transferase Fucokinase PF07959.12 ADV19739.1 - 4.5e-05 22.6 0.1 0.0001 21.4 0.1 1.5 2 0 0 2 2 2 1 L-fucokinase NTP_transf_3 PF12804.7 ADV19739.1 - 0.00021 21.7 0.0 0.0005 20.5 0.0 1.6 2 0 0 2 2 2 1 MobA-like NTP transferase domain DUF4954 PF16314.5 ADV19739.1 - 0.018 13.2 0.3 0.027 12.6 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4954) CTP_transf_3 PF02348.19 ADV19739.1 - 0.2 11.5 0.0 0.42 10.5 0.0 1.4 1 0 0 1 1 1 0 Cytidylyltransferase MFS_1 PF07690.16 ADV19742.1 - 7.4e-07 28.4 42.9 2.7e-05 23.3 11.3 3.2 2 1 0 2 2 2 2 Major Facilitator Superfamily SHR3_chaperone PF08229.11 ADV19744.1 - 7.7e-37 126.1 0.0 9.6e-37 125.8 0.0 1.0 1 0 0 1 1 1 1 ER membrane protein SH3 Peptidase_M48_N PF16491.5 ADV19744.1 - 0.0044 16.9 1.8 0.0074 16.2 1.8 1.3 1 0 0 1 1 1 1 CAAX prenyl protease N-terminal, five membrane helices GATA PF00320.27 ADV19745.1 - 0.00097 18.7 5.4 0.0019 17.8 5.4 1.5 1 0 0 1 1 1 1 GATA zinc finger Nudix_N_2 PF14803.6 ADV19745.1 - 4.4 7.3 7.6 12 5.9 7.6 1.7 1 0 0 1 1 1 0 Nudix N-terminal DAP3 PF10236.9 ADV19746.1 - 1.8e-85 286.9 0.0 2.1e-85 286.6 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 AAA_16 PF13191.6 ADV19746.1 - 3.9e-05 24.1 0.1 6.9e-05 23.3 0.1 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ADV19746.1 - 0.0003 21.1 0.6 0.005 17.1 0.6 2.2 1 1 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 ADV19746.1 - 0.00098 19.1 0.1 0.0019 18.1 0.1 1.4 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea Helicase_RecD PF05127.14 ADV19746.1 - 0.018 14.9 0.0 0.036 13.9 0.0 1.6 1 1 0 1 1 1 0 Helicase AAA_29 PF13555.6 ADV19746.1 - 0.055 13.2 0.1 0.12 12.1 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_10 PF12846.7 ADV19746.1 - 0.19 10.6 2.1 0.98 8.3 2.1 1.8 1 1 0 1 1 1 0 AAA-like domain eIF3m_C_helix PF18005.1 ADV19747.1 - 2.8e-08 33.3 2.1 6.1e-08 32.2 2.1 1.6 1 0 0 1 1 1 1 eIF3 subunit M, C-terminal helix PCI PF01399.27 ADV19747.1 - 1.8e-06 28.4 0.1 7.8e-06 26.3 0.0 2.2 2 0 0 2 2 2 1 PCI domain Vps5 PF09325.10 ADV19748.1 - 8.3e-14 51.7 7.0 1.1e-13 51.3 7.0 1.1 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.24 ADV19748.1 - 9.3e-10 38.5 0.0 2.2e-09 37.3 0.0 1.6 1 0 0 1 1 1 1 PX domain DUF4834 PF16118.5 ADV19750.1 - 0.025 15.5 0.5 0.067 14.2 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) FAM176 PF14851.6 ADV19750.1 - 1 9.0 3.9 3.3 7.3 3.9 1.8 1 1 0 1 1 1 0 FAM176 family DDE_Tnp_4 PF13359.6 ADV19751.1 - 1.9e-27 95.8 0.1 4.4e-15 55.7 0.0 2.1 1 1 1 2 2 2 2 DDE superfamily endonuclease DDE_Tnp_1 PF01609.21 ADV19751.1 - 1.2e-05 25.1 0.6 7.1e-05 22.5 0.6 2.3 1 1 0 1 1 1 1 Transposase DDE domain Plant_tran PF04827.14 ADV19751.1 - 0.015 14.9 0.2 0.19 11.3 0.0 2.0 1 1 0 2 2 2 0 Plant transposon protein Mito_carr PF00153.27 ADV19753.1 - 3.4e-65 216.0 2.3 3e-21 75.2 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Anoctamin PF04547.12 ADV19754.1 - 2e-88 297.2 0.1 2.8e-88 296.8 0.1 1.0 1 0 0 1 1 1 1 Calcium-activated chloride channel WD40 PF00400.32 ADV19755.1 - 2.8e-06 28.0 4.7 0.0011 19.7 0.1 4.3 4 0 0 4 4 4 2 WD domain, G-beta repeat Mago-bind PF09282.10 ADV19756.1 - 1.2e-14 53.8 2.2 2.9e-14 52.6 2.2 1.7 1 0 0 1 1 1 1 Mago binding DUF4889 PF16230.5 ADV19756.1 - 0.16 12.2 0.5 14 6.0 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4889) Abhydrolase_1 PF00561.20 ADV19757.1 - 5.4e-22 78.7 0.4 4.4e-18 65.9 0.3 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ADV19757.1 - 1.2e-16 62.0 0.0 1.8e-16 61.4 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ADV19757.1 - 2.2e-11 43.5 0.0 4.4e-11 42.5 0.0 1.6 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 ADV19757.1 - 3.4e-07 30.6 0.0 4.9e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain PGAP1 PF07819.13 ADV19757.1 - 1.9e-05 24.5 1.1 0.012 15.4 0.4 3.0 2 1 0 2 2 2 1 PGAP1-like protein Palm_thioest PF02089.15 ADV19757.1 - 2.6e-05 24.2 0.0 3.5e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Chlorophyllase2 PF12740.7 ADV19757.1 - 0.011 14.7 0.1 0.031 13.2 0.0 1.7 1 1 1 2 2 2 0 Chlorophyllase enzyme DUF676 PF05057.14 ADV19757.1 - 0.032 13.7 0.0 0.057 12.9 0.0 1.3 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Chlorophyllase PF07224.11 ADV19757.1 - 0.032 13.2 0.0 0.058 12.4 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase AA_permease_2 PF13520.6 ADV19758.1 - 7.8e-36 123.8 43.3 1.1e-35 123.3 43.3 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 ADV19758.1 - 4.4e-22 78.3 35.5 5.9e-22 77.9 35.5 1.1 1 0 0 1 1 1 1 Amino acid permease DDE_1 PF03184.19 ADV19759.1 - 3.7e-19 69.1 0.0 6e-19 68.3 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 ADV19759.1 - 0.0067 16.2 0.0 0.041 13.6 0.0 2.1 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 ADV19759.1 - 0.028 14.4 0.0 0.11 12.5 0.0 2.1 1 0 0 1 1 1 0 Tc5 transposase DNA-binding domain Complex1_LYR_2 PF13233.6 ADV19760.1 - 0.00014 22.6 0.1 0.00018 22.2 0.1 1.3 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.15 ADV19760.1 - 0.0018 18.3 0.2 0.0042 17.1 0.2 1.7 1 1 0 1 1 1 1 Complex 1 protein (LYR family) DUF1823 PF08853.11 ADV19760.1 - 0.033 14.4 2.7 0.085 13.1 0.4 2.0 1 1 0 2 2 2 0 Domain of unknown function (DUF1823) cNMP_binding PF00027.29 ADV19761.1 - 1e-38 131.3 0.3 5.7e-19 68.0 0.1 2.7 2 1 0 2 2 2 2 Cyclic nucleotide-binding domain RIIa PF02197.17 ADV19761.1 - 7.6e-07 28.7 0.0 1.4e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit WD40 PF00400.32 ADV19763.1 - 0.00017 22.3 2.2 33 5.6 2.0 4.8 4 0 0 4 4 4 2 WD domain, G-beta repeat TFIIIC_delta PF12657.7 ADV19763.1 - 0.12 12.3 0.0 0.26 11.2 0.0 1.5 2 0 0 2 2 2 0 Transcription factor IIIC subunit delta N-term DUF760 PF05542.11 ADV19763.1 - 0.16 12.3 0.0 72 3.8 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF760) Dynamin_M PF01031.20 ADV19764.1 - 5.9e-104 347.3 0.0 1.2e-103 346.3 0.0 1.5 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.23 ADV19764.1 - 2.3e-55 187.2 0.0 3.7e-55 186.5 0.0 1.3 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 ADV19764.1 - 1e-28 99.3 0.6 2.6e-28 98.0 0.6 1.7 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 ADV19764.1 - 0.00038 20.5 0.3 0.0013 18.8 0.3 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_15 PF13175.6 ADV19764.1 - 0.07 12.8 0.8 2 8.0 0.4 2.4 2 0 0 2 2 2 0 AAA ATPase domain BTB PF00651.31 ADV19766.1 - 1.6e-06 28.3 0.0 3e-06 27.4 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain vATP-synt_E PF01991.18 ADV19767.1 - 1.1e-54 184.9 6.5 1.3e-54 184.7 6.5 1.0 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit Pkinase PF00069.25 ADV19768.1 - 4.8e-26 91.7 0.0 6.4e-26 91.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV19768.1 - 1.1e-12 47.8 0.0 1.5e-12 47.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase CK1gamma_C PF12605.8 ADV19768.1 - 3.2e-09 37.8 7.9 8.8e-09 36.5 7.9 1.7 1 0 0 1 1 1 1 Casein kinase 1 gamma C terminal Pkinase_fungal PF17667.1 ADV19768.1 - 4.4e-07 29.0 0.0 6.2e-07 28.5 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 ADV19768.1 - 0.032 14.2 0.0 8.1 6.3 0.0 2.4 2 0 0 2 2 2 0 Phosphotransferase enzyme family MBOAT_2 PF13813.6 ADV19769.1 - 2.4e-16 59.8 2.0 2.4e-16 59.8 2.0 4.3 4 2 1 5 5 5 1 Membrane bound O-acyl transferase family Exo_endo_phos PF03372.23 ADV19770.1 - 1.9e-21 76.6 0.0 3.4e-21 75.8 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family MFS_1 PF07690.16 ADV19771.1 - 2e-33 115.8 38.8 4.5e-33 114.6 36.5 1.9 2 0 0 2 2 2 1 Major Facilitator Superfamily MNSV_P7B PF06692.11 ADV19771.1 - 0.13 12.3 0.5 0.38 10.8 0.5 1.7 1 0 0 1 1 1 0 Melon necrotic spot virus P7B protein HCO3_cotransp PF00955.21 ADV19772.1 - 3.4e-77 260.4 4.9 2.7e-36 125.5 2.5 3.0 2 1 1 3 3 3 3 HCO3- transporter family Sulfate_transp PF00916.20 ADV19772.1 - 0.0091 14.8 7.0 0.0096 14.7 0.9 2.7 2 1 0 2 2 2 2 Sulfate permease family zf-RING_UBOX PF13445.6 ADV19773.1 - 2e-07 30.9 2.5 2e-07 30.9 2.5 2.0 2 0 0 2 2 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 ADV19773.1 - 2.2e-06 27.7 1.7 2.2e-06 27.7 1.7 3.4 3 1 1 4 4 3 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 ADV19773.1 - 2.4e-06 27.3 2.5 2.4e-06 27.3 2.5 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ADV19773.1 - 8.6e-06 25.5 2.5 8.6e-06 25.5 2.5 2.6 2 2 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ADV19773.1 - 1.6e-05 24.6 0.6 1.6e-05 24.6 0.6 3.1 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_10 PF16685.5 ADV19773.1 - 0.00059 19.9 1.7 0.0021 18.2 1.7 1.9 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-RING_6 PF14835.6 ADV19773.1 - 0.00087 19.1 0.5 0.00087 19.1 0.5 2.4 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-CpG_bind_C PF12269.8 ADV19773.1 - 0.00089 19.1 2.4 0.0025 17.6 2.4 1.7 1 0 0 1 1 1 1 CpG binding protein zinc finger C terminal domain Prok-RING_4 PF14447.6 ADV19773.1 - 0.0011 18.8 1.5 0.0011 18.8 1.5 2.3 2 0 0 2 2 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 ADV19773.1 - 0.002 18.0 9.8 0.002 18.0 9.8 2.9 2 1 0 2 2 1 1 zinc-RING finger domain ATG16 PF08614.11 ADV19773.1 - 0.014 15.6 5.6 0.014 15.6 5.6 2.2 2 1 0 2 2 1 0 Autophagy protein 16 (ATG16) DUF3450 PF11932.8 ADV19773.1 - 0.016 14.5 6.1 0.027 13.8 6.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Macoilin PF09726.9 ADV19773.1 - 0.041 12.5 9.8 0.057 12.0 9.8 1.1 1 0 0 1 1 1 0 Macoilin family Vps53_N PF04100.12 ADV19773.1 - 0.18 10.7 2.6 0.28 10.1 2.6 1.2 1 0 0 1 1 1 0 Vps53-like, N-terminal Lzipper-MIP1 PF14389.6 ADV19773.1 - 0.76 10.1 8.6 2.5 8.4 1.5 2.4 1 1 1 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 DivIC PF04977.15 ADV19773.1 - 1.7 8.5 7.0 0.73 9.6 3.3 2.1 1 1 1 2 2 2 0 Septum formation initiator FmiP_Thoc5 PF09766.9 ADV19773.1 - 6.1 6.0 12.9 0.3 10.3 4.3 2.1 2 0 0 2 2 2 0 Fms-interacting protein/Thoc5 Rabaptin PF03528.15 ADV19773.1 - 6.3 5.4 12.2 3.7 6.1 9.0 1.8 2 0 0 2 2 2 0 Rabaptin ADH_N_2 PF16884.5 ADV19774.1 - 3.7e-32 110.4 0.0 9.7e-32 109.1 0.0 1.7 2 0 0 2 2 2 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.26 ADV19774.1 - 1.1e-22 80.4 0.0 2.2e-22 79.4 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ADV19774.1 - 1.3e-08 36.0 0.0 2.2e-08 35.3 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Semialdhyde_dh PF01118.24 ADV19774.1 - 0.003 18.0 0.0 0.0057 17.1 0.0 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain TrkA_N PF02254.18 ADV19774.1 - 0.16 12.2 0.0 0.4 10.9 0.0 1.7 1 0 0 1 1 1 0 TrkA-N domain TAFII55_N PF04658.13 ADV19775.1 - 6.9e-48 162.4 0.0 1.2e-47 161.6 0.0 1.4 1 0 0 1 1 1 1 TAFII55 protein conserved region Ribosomal_L9_N PF01281.19 ADV19776.1 - 9.9e-09 34.6 0.1 2.1e-08 33.6 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein L9, N-terminal domain ERCC3_RAD25_C PF16203.5 ADV19777.1 - 2.6e-118 393.7 0.0 4.6e-118 392.9 0.0 1.4 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Helicase_C_3 PF13625.6 ADV19777.1 - 1.8e-33 115.3 0.0 4e-33 114.3 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 ADV19777.1 - 5.2e-18 65.6 0.0 8.9e-18 64.9 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 ADV19777.1 - 8.4e-12 45.4 0.0 2.3e-11 44.0 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 ADV19777.1 - 1.9e-06 26.8 0.0 2.9e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain 6PF2K PF01591.18 ADV19779.1 - 9.7e-57 191.8 0.0 1.4e-56 191.3 0.0 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 ADV19779.1 - 4.1e-26 91.9 0.0 6.7e-25 87.9 0.0 2.5 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) KTI12 PF08433.10 ADV19779.1 - 0.01 15.3 0.0 0.016 14.7 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_33 PF13671.6 ADV19779.1 - 0.013 15.7 0.0 0.027 14.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain Sin_N PF04801.13 ADV19780.1 - 3.7e-16 59.4 0.0 2.5e-15 56.7 0.0 1.9 1 1 0 1 1 1 1 Sin-like protein conserved region PAG PF15347.6 ADV19780.1 - 0.2 10.6 0.2 0.29 10.1 0.2 1.1 1 0 0 1 1 1 0 Phosphoprotein associated with glycosphingolipid-enriched Aminotran_3 PF00202.21 ADV19781.1 - 1.9e-97 326.5 0.0 2.4e-97 326.2 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Serine_rich PF08824.10 ADV19781.1 - 0.26 11.3 0.0 0.42 10.6 0.0 1.2 1 0 0 1 1 1 0 Serine rich protein interaction domain Hid1 PF12722.7 ADV19782.1 - 8 4.5 5.8 9.4 4.2 5.8 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein HMG_box PF00505.19 ADV19783.1 - 1.1e-11 45.0 1.4 2.1e-11 44.0 1.4 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ADV19783.1 - 0.00097 19.7 0.3 0.0025 18.4 0.3 1.7 1 0 0 1 1 1 1 HMG-box domain Use1 PF09753.9 ADV19783.1 - 1.7 8.3 7.5 0.2 11.3 3.3 1.5 2 0 0 2 2 2 0 Membrane fusion protein Use1 VPS9 PF02204.18 ADV19784.1 - 4.2e-19 68.7 0.0 4.4e-16 59.0 0.0 2.3 2 0 0 2 2 2 2 Vacuolar sorting protein 9 (VPS9) domain PrkA PF06798.12 ADV19784.1 - 0.01 15.5 0.5 0.023 14.4 0.2 1.7 2 0 0 2 2 2 0 PrkA serine protein kinase C-terminal domain DUF5614 PF18474.1 ADV19785.1 - 0.0011 18.3 0.0 0.0023 17.3 0.0 1.5 1 0 0 1 1 1 1 Family of unknown function (DUF5614) DUF1308 PF07000.11 ADV19785.1 - 0.0012 18.8 0.0 0.0026 17.7 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1308) DUF5641 PF18701.1 ADV19785.1 - 0.095 12.9 0.0 0.31 11.2 0.0 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5641) BppL_N PF18338.1 ADV19785.1 - 0.13 12.1 0.0 0.27 11.1 0.0 1.5 1 0 0 1 1 1 0 Lower baseplate protein N-terminal domain TMIE PF16038.5 ADV19785.1 - 0.14 12.0 0.0 0.37 10.6 0.0 1.7 1 0 0 1 1 1 0 TMIE protein FAT PF02259.23 ADV19786.1 - 1.8e-63 214.8 0.2 3.4e-63 213.9 0.2 1.5 1 0 0 1 1 1 1 FAT domain PI3_PI4_kinase PF00454.27 ADV19786.1 - 1.5e-22 80.6 0.1 4.5e-22 79.1 0.1 1.9 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 ADV19786.1 - 0.012 15.4 0.1 0.034 14.0 0.1 1.9 1 0 0 1 1 1 0 FATC domain DUF2275 PF10039.9 ADV19786.1 - 0.039 14.1 0.3 0.082 13.0 0.3 1.4 1 0 0 1 1 1 0 Predicted integral membrane protein (DUF2275) Urb2 PF10441.9 ADV19787.1 - 7.2e-21 75.1 0.0 2.3e-18 66.9 0.0 3.6 4 0 0 4 4 4 1 Urb2/Npa2 family DUF1719 PF08224.11 ADV19787.1 - 0.044 12.9 0.0 0.093 11.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1719) TSNAXIP1_N PF15739.5 ADV19787.1 - 0.083 13.3 0.1 0.24 11.8 0.1 1.7 1 0 0 1 1 1 0 Translin-associated factor X-interacting N-terminus PALP PF00291.25 ADV19788.1 - 7.7e-52 176.5 0.0 1.3e-51 175.8 0.0 1.4 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme OHCU_decarbox PF09349.10 ADV19789.1 - 6.7e-45 153.3 0.0 8.2e-45 153.1 0.0 1.1 1 0 0 1 1 1 1 OHCU decarboxylase Ribosomal_S4e PF00900.20 ADV19790.1 - 3.5e-36 122.9 0.1 7.3e-36 121.9 0.1 1.6 1 0 0 1 1 1 1 Ribosomal family S4e 40S_S4_C PF16121.5 ADV19790.1 - 1.6e-25 88.5 0.1 2.9e-25 87.7 0.1 1.5 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus RS4NT PF08071.12 ADV19790.1 - 3.7e-21 74.9 6.1 8.9e-21 73.7 6.1 1.7 1 0 0 1 1 1 1 RS4NT (NUC023) domain S4 PF01479.25 ADV19790.1 - 3.4e-08 33.1 0.0 7.7e-08 31.9 0.0 1.7 1 0 0 1 1 1 1 S4 domain KOW PF00467.29 ADV19790.1 - 1.4e-07 31.2 4.2 4.8e-07 29.5 4.2 2.0 1 0 0 1 1 1 1 KOW motif MMR_HSR1 PF01926.23 ADV19791.1 - 4.8e-15 55.6 0.0 1.8e-14 53.8 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ADV19791.1 - 5.3e-07 29.3 0.0 1.1e-06 28.3 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 ADV19791.1 - 1.1e-06 28.6 0.0 0.00024 21.0 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase AIG1 PF04548.16 ADV19791.1 - 0.00034 20.0 0.0 0.00083 18.7 0.0 1.6 2 0 0 2 2 2 1 AIG1 family Dynamin_N PF00350.23 ADV19791.1 - 0.0098 16.0 0.1 0.0098 16.0 0.1 2.9 3 1 1 4 4 4 1 Dynamin family Septin PF00735.18 ADV19791.1 - 0.031 13.6 0.0 3.3 6.9 0.0 2.2 2 0 0 2 2 2 0 Septin Roc PF08477.13 ADV19791.1 - 0.031 14.5 0.6 0.41 10.9 0.0 2.9 4 0 0 4 4 4 0 Ras of Complex, Roc, domain of DAPkinase Pkinase PF00069.25 ADV19792.1 - 5.4e-38 130.9 0.0 3.1e-23 82.5 0.0 3.2 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 ADV19792.1 - 1.1e-14 54.3 0.0 1.2e-10 41.1 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 ADV19792.1 - 0.00021 21.3 0.0 0.0032 17.4 0.0 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ADV19792.1 - 0.0043 15.9 0.0 0.0099 14.7 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase FTA2 PF13095.6 ADV19792.1 - 0.0044 16.7 0.0 0.0076 15.9 0.0 1.5 1 0 0 1 1 1 1 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 ADV19792.1 - 0.013 14.8 0.1 0.024 14.0 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ADV19792.1 - 0.042 13.2 0.0 7.8 5.7 0.0 2.4 2 0 0 2 2 2 0 Kinase-like KH_1 PF00013.29 ADV19793.1 - 4.1e-37 125.8 2.0 8.2e-09 35.2 0.0 8.6 9 0 0 9 9 9 6 KH domain DUF499 PF04465.12 ADV19793.1 - 0.08 10.7 0.3 0.13 10.0 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF499) FAM76 PF16046.5 ADV19794.1 - 6.9 5.9 8.5 13 5.0 8.5 1.3 1 0 0 1 1 1 0 FAM76 protein PRA1 PF03208.19 ADV19795.1 - 2.5e-32 111.5 0.0 3e-32 111.2 0.0 1.0 1 0 0 1 1 1 1 PRA1 family protein PSI_PsaJ PF01701.18 ADV19795.1 - 0.17 12.5 5.7 1.5 9.4 1.6 2.5 2 0 0 2 2 2 0 Photosystem I reaction centre subunit IX / PsaJ NEMP PF10225.9 ADV19795.1 - 0.35 10.5 2.8 0.21 11.2 0.8 1.6 2 0 0 2 2 2 0 NEMP family YrhK PF14145.6 ADV19795.1 - 0.46 10.4 7.2 21 5.1 7.2 2.3 1 1 0 1 1 1 0 YrhK-like protein YCII PF03795.14 ADV19796.1 - 5e-08 33.3 0.0 9.4e-08 32.4 0.0 1.4 1 1 0 1 1 1 1 YCII-related domain Sec7 PF01369.20 ADV19797.1 - 5.3e-31 107.7 0.2 8.7e-31 107.0 0.2 1.3 1 0 0 1 1 1 1 Sec7 domain PH PF00169.29 ADV19797.1 - 1.5e-12 48.0 0.3 3.4e-12 46.8 0.3 1.6 1 0 0 1 1 1 1 PH domain PH_9 PF15410.6 ADV19797.1 - 6.2e-09 36.2 0.3 1.5e-08 35.0 0.3 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain TPR_16 PF13432.6 ADV19798.1 - 1.9e-09 38.0 1.3 0.17 12.5 0.1 4.2 3 1 0 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.6 ADV19798.1 - 2.7e-07 30.8 1.8 4.2 8.4 0.0 4.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 ADV19798.1 - 7.9e-06 26.3 0.7 0.55 10.8 0.0 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 ADV19798.1 - 4.7e-05 23.2 8.4 0.034 14.2 0.2 4.5 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 ADV19798.1 - 0.00087 19.3 4.4 0.38 11.1 0.0 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 ADV19798.1 - 0.0011 19.2 2.6 0.14 12.5 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 ADV19798.1 - 0.01 15.8 5.9 5.9 7.2 0.2 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 ADV19798.1 - 0.053 13.4 5.4 0.12 12.2 0.2 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat Sel1 PF08238.12 ADV19798.1 - 0.11 13.2 0.0 0.42 11.4 0.0 2.0 1 0 0 1 1 1 0 Sel1 repeat TPR_6 PF13174.6 ADV19798.1 - 0.24 12.1 3.0 95 4.0 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat Glyco_hydro_5_C PF18564.1 ADV19799.1 - 1e-14 54.8 0.3 2.1e-14 53.8 0.3 1.6 1 0 0 1 1 1 1 Glycoside hydrolase family 5 C-terminal domain Cellulase PF00150.18 ADV19799.1 - 1.3e-10 41.2 0.0 9.9e-08 31.7 0.0 3.1 2 1 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) CPSase_L_D2 PF02786.17 ADV19800.1 - 1.6e-112 374.1 0.6 1.3e-81 273.1 0.1 2.4 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain GATase PF00117.28 ADV19800.1 - 9.5e-48 162.5 0.0 6.3e-47 159.8 0.0 2.3 2 0 0 2 2 2 1 Glutamine amidotransferase class-I OTCace_N PF02729.21 ADV19800.1 - 2.6e-45 154.1 0.0 7.4e-45 152.6 0.0 1.9 2 0 0 2 2 2 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain CPSase_sm_chain PF00988.22 ADV19800.1 - 1.1e-44 151.3 0.0 3e-44 150.0 0.0 1.8 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain CPSase_L_D3 PF02787.19 ADV19800.1 - 3.4e-39 133.9 0.1 8e-39 132.8 0.1 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain OTCace PF00185.24 ADV19800.1 - 4.5e-31 108.0 0.0 5.5e-30 104.5 0.0 2.3 2 0 0 2 2 2 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain MGS PF02142.22 ADV19800.1 - 8.8e-20 70.7 0.0 5.1e-19 68.3 0.0 2.5 1 0 0 1 1 1 1 MGS-like domain Dala_Dala_lig_C PF07478.13 ADV19800.1 - 6.8e-17 61.7 0.7 2.2e-08 33.9 0.1 2.5 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 ADV19800.1 - 1.2e-16 60.8 0.3 3.2e-08 33.3 0.0 2.5 2 0 0 2 2 2 2 ATP-grasp domain ATPgrasp_Ter PF15632.6 ADV19800.1 - 8.3e-09 35.3 0.1 0.00042 20.1 0.0 2.7 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon Peptidase_C26 PF07722.13 ADV19800.1 - 1.7e-06 27.9 0.0 0.0032 17.2 0.0 2.7 1 1 0 2 2 2 2 Peptidase C26 DJ-1_PfpI PF01965.24 ADV19800.1 - 2.3e-05 24.2 0.0 0.054 13.3 0.0 4.4 4 0 0 4 4 4 1 DJ-1/PfpI family ATP-grasp_3 PF02655.14 ADV19800.1 - 9.9e-05 22.4 0.3 0.25 11.4 0.0 2.8 2 0 0 2 2 2 2 ATP-grasp domain RimK PF08443.11 ADV19800.1 - 0.0018 17.9 0.1 0.32 10.6 0.1 2.6 2 0 0 2 2 2 1 RimK-like ATP-grasp domain TrkA_N PF02254.18 ADV19800.1 - 0.012 15.8 0.1 0.45 10.8 0.0 2.9 2 0 0 2 2 2 0 TrkA-N domain TBCC PF07986.12 ADV19801.1 - 3e-13 49.6 0.7 1.8e-07 30.9 0.0 2.4 2 0 0 2 2 2 2 Tubulin binding cofactor C TBCC_N PF16752.5 ADV19801.1 - 0.00019 21.8 0.2 0.00045 20.6 0.2 1.5 1 0 0 1 1 1 1 Tubulin-specific chaperone C N-terminal domain dCMP_cyt_deam_1 PF00383.23 ADV19803.1 - 1.3e-16 60.3 0.0 1.6e-16 60.0 0.0 1.1 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 ADV19803.1 - 6.2e-08 32.5 0.0 7.9e-08 32.1 0.0 1.1 1 0 0 1 1 1 1 MafB19-like deaminase SNAD4 PF18750.1 ADV19803.1 - 0.051 13.7 0.1 0.09 12.9 0.1 1.4 1 0 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 4 Sof1 PF04158.14 ADV19804.1 - 7.1e-22 77.5 14.8 1.3e-21 76.7 14.8 1.4 1 0 0 1 1 1 1 Sof1-like domain WD40 PF00400.32 ADV19804.1 - 1.7e-18 66.6 10.9 1.9e-07 31.6 0.1 7.2 7 0 0 7 7 7 3 WD domain, G-beta repeat Gly_transf_sug PF04488.15 ADV19804.1 - 2.8e-06 27.9 0.0 6.9e-06 26.6 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif ANAPC4_WD40 PF12894.7 ADV19804.1 - 3.8e-05 23.9 0.0 0.031 14.6 0.0 3.4 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain RBM39linker PF15519.6 ADV19804.1 - 0.088 13.9 0.0 0.25 12.5 0.0 1.8 1 0 0 1 1 1 0 linker between RRM2 and RRM3 domains in RBM39 protein bZIP_1 PF00170.21 ADV19805.1 - 1.1e-08 35.1 7.9 1.1e-08 35.1 7.9 1.8 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 ADV19805.1 - 0.0002 21.3 5.2 0.0002 21.3 5.2 2.0 1 1 1 2 2 2 1 Basic region leucine zipper bZIP_Maf PF03131.17 ADV19805.1 - 0.0042 17.6 6.1 0.0042 17.6 6.1 2.2 2 0 0 2 2 2 1 bZIP Maf transcription factor Cep57_CLD_2 PF14197.6 ADV19805.1 - 0.017 15.2 4.5 0.04 14.0 4.5 1.6 1 0 0 1 1 1 0 Centrosome localisation domain of PPC89 CENP-F_leu_zip PF10473.9 ADV19805.1 - 0.017 15.1 10.0 0.036 14.1 10.0 1.5 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF2599 PF10783.9 ADV19805.1 - 0.028 15.0 0.2 0.07 13.8 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2599) HALZ PF02183.18 ADV19805.1 - 0.12 12.6 0.4 0.26 11.5 0.4 1.6 1 0 0 1 1 1 0 Homeobox associated leucine zipper FlaC_arch PF05377.11 ADV19805.1 - 2 8.9 4.4 5.8 7.4 1.2 2.5 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) RasGAP_C PF03836.15 ADV19805.1 - 5.9 7.0 10.9 0.45 10.7 5.8 1.8 2 0 0 2 2 2 0 RasGAP C-terminus FUSC_2 PF13515.6 ADV19806.1 - 3.1e-17 62.9 7.0 3.1e-17 62.9 7.0 2.7 2 1 0 2 2 2 1 Fusaric acid resistance protein-like ALMT PF11744.8 ADV19806.1 - 4.4e-06 25.8 5.8 5.2e-05 22.3 5.8 2.2 1 1 0 1 1 1 1 Aluminium activated malate transporter FUSC PF04632.12 ADV19806.1 - 2.2e-05 23.2 11.4 2.2e-05 23.2 11.4 2.2 2 1 0 2 2 2 1 Fusaric acid resistance protein family ArAE_1 PF06081.11 ADV19806.1 - 2.1 8.5 8.3 0.18 12.0 2.9 2.0 2 0 0 2 2 2 0 Aromatic acid exporter family member 1 LRR_8 PF13855.6 ADV19807.1 - 1.2e-06 28.1 10.1 0.14 12.0 0.9 5.7 4 1 2 6 6 6 4 Leucine rich repeat LRR_4 PF12799.7 ADV19807.1 - 2.7e-05 24.4 20.0 0.094 13.2 0.0 6.5 4 2 2 6 6 6 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 ADV19807.1 - 0.0017 17.9 0.1 0.53 9.8 0.0 2.6 2 1 0 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.33 ADV19807.1 - 0.022 15.3 11.3 11 7.0 0.0 6.0 5 2 1 6 6 6 0 Leucine Rich Repeat KH_8 PF17903.1 ADV19808.1 - 0.0022 18.0 0.0 0.006 16.7 0.0 1.7 1 0 0 1 1 1 1 Krr1 KH1 domain KH_1 PF00013.29 ADV19808.1 - 0.013 15.3 0.9 0.036 13.9 0.9 1.7 1 0 0 1 1 1 0 KH domain WD40 PF00400.32 ADV19809.1 - 1.7e-22 79.3 0.1 3.8e-05 24.3 0.0 6.0 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV19809.1 - 4.5e-11 42.9 0.1 0.012 15.9 0.0 4.4 2 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ADV19809.1 - 5.1e-07 29.0 0.4 0.0028 16.7 0.0 3.2 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ADV19809.1 - 4.1e-06 26.8 0.1 0.00027 20.9 0.0 3.1 2 1 2 4 4 4 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ADV19809.1 - 3.3e-05 22.7 0.1 0.053 12.2 0.1 2.5 2 1 1 3 3 3 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ADV19809.1 - 0.0011 17.6 0.0 0.0019 16.8 0.0 1.4 1 0 0 1 1 1 1 Cytochrome D1 heme domain WD40_like PF17005.5 ADV19809.1 - 0.049 13.0 0.0 6.1 6.1 0.0 3.3 2 1 2 4 4 4 0 WD40-like domain Coatomer_WDAD PF04053.14 ADV19809.1 - 0.054 12.5 0.1 0.65 9.0 0.0 2.2 1 1 0 2 2 2 0 Coatomer WD associated region Str_synth PF03088.16 ADV19809.1 - 0.078 13.1 0.0 0.17 12.0 0.0 1.6 1 0 0 1 1 1 0 Strictosidine synthase Glyco_hydro_61 PF03443.14 ADV19810.1 - 1.4e-37 129.6 0.6 1.9e-37 129.2 0.0 1.5 2 0 0 2 2 2 1 Glycosyl hydrolase family 61 Sporozoite_P67 PF05642.11 ADV19810.1 - 0.14 10.2 6.2 0.17 10.0 6.2 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen FAM104 PF15434.6 ADV19810.1 - 0.64 10.6 8.2 1.2 9.7 8.2 1.5 1 0 0 1 1 1 0 Family 104 FAM199X PF15814.5 ADV19810.1 - 0.84 8.6 18.9 1.1 8.2 18.9 1.2 1 0 0 1 1 1 0 Protein family FAM199X CAP59_mtransfer PF11735.8 ADV19811.1 - 3.6e-37 128.3 0.0 5.9e-37 127.6 0.0 1.3 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 Trypan_PARP PF05887.11 ADV19811.1 - 0.0018 18.3 4.7 0.0018 18.3 4.7 2.0 2 0 0 2 2 2 1 Procyclic acidic repetitive protein (PARP) Ion_trans PF00520.31 ADV19812.1 - 2.5e-05 23.6 19.1 0.0007 18.9 18.2 2.4 2 1 0 2 2 2 1 Ion transport protein PKD_channel PF08016.12 ADV19812.1 - 3.5e-05 22.7 7.6 6.4e-05 21.8 6.6 2.0 1 1 0 1 1 1 1 Polycystin cation channel LSM PF01423.22 ADV19813.1 - 8.9e-18 63.7 0.1 1.1e-17 63.5 0.1 1.1 1 0 0 1 1 1 1 LSM domain DUF150_C PF17384.2 ADV19813.1 - 0.024 14.8 0.1 1.3 9.2 0.0 2.1 2 0 0 2 2 2 0 RimP C-terminal SH3 domain bZIP_2 PF07716.15 ADV19815.1 - 0.00027 20.9 13.6 0.00027 20.9 13.6 2.6 2 1 0 2 2 2 1 Basic region leucine zipper bZIP_1 PF00170.21 ADV19815.1 - 0.0005 20.1 13.1 0.0015 18.6 13.1 1.7 1 1 0 1 1 1 1 bZIP transcription factor bZIP_Maf PF03131.17 ADV19815.1 - 0.019 15.4 9.1 0.019 15.4 9.1 1.8 2 0 0 2 2 2 0 bZIP Maf transcription factor Cut12 PF11500.8 ADV19815.1 - 0.061 13.3 3.2 0.098 12.6 3.2 1.3 1 0 0 1 1 1 0 Spindle pole body formation-associated protein DivIC PF04977.15 ADV19815.1 - 0.19 11.5 2.2 0.36 10.6 2.2 1.4 1 0 0 1 1 1 0 Septum formation initiator DUF724 PF05266.14 ADV19815.1 - 0.36 10.6 3.3 0.59 9.9 3.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) XhlA PF10779.9 ADV19815.1 - 2.6 8.3 4.4 5 7.4 4.4 1.3 1 0 0 1 1 1 0 Haemolysin XhlA Hat1_N PF10394.9 ADV19816.1 - 9.4e-54 182.0 0.0 1.4e-53 181.4 0.0 1.3 1 0 0 1 1 1 1 Histone acetyl transferase HAT1 N-terminus Acetyltransf_1 PF00583.25 ADV19816.1 - 2.9e-08 34.0 0.0 1.1e-07 32.0 0.0 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family MOZ_SAS PF01853.18 ADV19816.1 - 0.0012 18.5 0.0 0.0019 17.9 0.0 1.2 1 0 0 1 1 1 1 MOZ/SAS family Acetyltransf_7 PF13508.7 ADV19816.1 - 0.0068 16.8 0.0 0.02 15.3 0.0 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ADV19816.1 - 0.012 15.5 0.0 0.031 14.2 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Velvet PF11754.8 ADV19817.1 - 5.2e-64 216.6 0.1 1.1e-62 212.2 0.1 2.2 1 1 0 1 1 1 1 Velvet factor DNA_ligase_A_N PF04675.14 ADV19818.1 - 1.9e-33 116.3 0.0 3.3e-33 115.5 0.0 1.4 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_M PF01068.21 ADV19818.1 - 2e-33 115.8 0.9 2.3e-25 89.5 0.1 5.1 3 1 0 3 3 3 3 ATP dependent DNA ligase domain DNA_ligase_A_C PF04679.15 ADV19818.1 - 1e-19 70.9 0.0 2.7e-19 69.6 0.0 1.8 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region GTP_cyclohydro2 PF00925.20 ADV19819.1 - 9e-62 207.5 0.0 1.7e-61 206.6 0.0 1.4 1 1 0 1 1 1 1 GTP cyclohydrolase II HAUS2 PF15003.6 ADV19820.1 - 0.0081 15.9 0.4 0.028 14.2 0.1 2.0 2 0 0 2 2 2 1 HAUS augmin-like complex subunit 2 KAR9 PF08580.10 ADV19820.1 - 0.012 14.2 42.6 0.13 10.8 39.9 2.8 1 1 1 2 2 2 0 Yeast cortical protein KAR9 DUF2203 PF09969.9 ADV19820.1 - 0.069 13.9 0.8 0.24 12.1 0.2 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) Mod_r PF07200.13 ADV19820.1 - 0.082 13.0 8.0 0.35 10.9 4.9 2.4 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein FUSC PF04632.12 ADV19820.1 - 0.16 10.5 1.8 0.24 9.9 1.8 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family Com_YlbF PF06133.11 ADV19820.1 - 1 10.0 5.0 0.26 11.9 0.5 2.3 3 0 0 3 3 3 0 Control of competence regulator ComK, YlbF/YmcA BRE1 PF08647.11 ADV19820.1 - 1.7 8.8 7.4 6.6 6.9 0.1 3.0 2 1 0 2 2 2 0 BRE1 E3 ubiquitin ligase Seryl_tRNA_N PF02403.22 ADV19820.1 - 6.9 6.9 7.2 3.5 7.9 0.2 3.1 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain DEAD_2 PF06733.15 ADV19821.1 - 1.7e-53 180.9 0.0 3e-53 180.1 0.0 1.4 1 0 0 1 1 1 1 DEAD_2 Helicase_C_2 PF13307.6 ADV19821.1 - 2.7e-44 151.4 0.0 5.8e-44 150.3 0.0 1.6 1 0 0 1 1 1 1 Helicase C-terminal domain HBB PF06777.11 ADV19821.1 - 5.7e-42 143.6 3.6 2.2e-37 128.6 1.2 2.6 2 0 0 2 2 2 2 Helical and beta-bridge domain ResIII PF04851.15 ADV19821.1 - 6.1e-05 23.1 0.1 0.0093 16.0 0.0 2.8 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit DEAD PF00270.29 ADV19821.1 - 0.0012 18.6 0.0 0.61 9.8 0.0 2.6 2 0 0 2 2 2 2 DEAD/DEAH box helicase YtxC PF08812.11 ADV19821.1 - 0.024 14.2 1.2 0.15 11.7 0.1 2.5 1 1 1 2 2 2 0 YtxC-like family SNF2_N PF00176.23 ADV19821.1 - 0.062 12.0 0.0 2.3 6.8 0.0 2.2 2 0 0 2 2 2 0 SNF2 family N-terminal domain Exog_C PF18026.1 ADV19821.1 - 0.064 13.3 1.1 4.4 7.4 0.0 2.8 2 0 0 2 2 2 0 Endo/exonuclease (EXOG) C-terminal domain DUF2075 PF09848.9 ADV19821.1 - 0.08 12.2 0.0 13 4.9 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) PPR_2 PF13041.6 ADV19822.1 - 1.5e-10 41.1 0.0 0.00065 19.8 0.0 6.1 6 2 2 8 8 8 3 PPR repeat family PPR PF01535.20 ADV19822.1 - 2.3e-10 40.0 0.4 3.6 8.1 0.0 7.6 7 2 0 7 7 7 2 PPR repeat PPR_long PF17177.4 ADV19822.1 - 2e-06 27.3 0.0 0.068 12.5 0.0 4.1 3 1 1 4 4 4 3 Pentacotripeptide-repeat region of PRORP PPR_3 PF13812.6 ADV19822.1 - 2.3e-05 24.4 0.0 0.63 10.2 0.0 4.6 4 1 1 5 5 5 2 Pentatricopeptide repeat domain PPR_1 PF12854.7 ADV19822.1 - 0.00019 21.1 0.1 24 4.7 0.0 6.0 6 1 0 6 6 6 1 PPR repeat ATP13 PF12921.7 ADV19822.1 - 0.044 13.6 0.0 10 6.0 0.0 3.3 2 1 1 3 3 3 0 Mitochondrial ATPase expression RibD_C PF01872.17 ADV19823.1 - 1.5e-18 67.4 0.0 2.1e-18 66.9 0.0 1.2 1 0 0 1 1 1 1 RibD C-terminal domain SPT_ssu-like PF11779.8 ADV19824.1 - 1.8e-13 49.9 5.9 2.5e-13 49.4 5.9 1.3 1 0 0 1 1 1 1 Small subunit of serine palmitoyltransferase-like VASt PF16016.5 ADV19825.1 - 7.2e-43 146.6 0.1 1.2e-42 146.0 0.1 1.4 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain GRAM PF02893.20 ADV19825.1 - 4.1e-24 84.7 0.0 8.6e-24 83.6 0.0 1.6 1 0 0 1 1 1 1 GRAM domain NOA36 PF06524.12 ADV19825.1 - 0.4 9.9 5.3 0.62 9.3 5.3 1.2 1 0 0 1 1 1 0 NOA36 protein Cwf_Cwc_15 PF04889.12 ADV19825.1 - 0.45 10.2 6.4 0.091 12.5 2.3 1.9 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein CENP-B_dimeris PF09026.10 ADV19825.1 - 3.2 8.2 11.0 6.7 7.2 11.0 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF4834 PF16118.5 ADV19825.1 - 5 8.2 4.6 1.4 9.9 0.0 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) RNA_pol_3_Rpc31 PF11705.8 ADV19825.1 - 5.8 7.1 11.1 0.17 12.1 3.6 2.2 3 0 0 3 3 3 0 DNA-directed RNA polymerase III subunit Rpc31 Ribosomal_L30_N PF08079.12 ADV19828.1 - 2.5e-28 98.1 15.3 4.2e-28 97.4 15.3 1.4 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Ribosomal_L30 PF00327.20 ADV19828.1 - 8.6e-16 57.6 2.0 1.6e-15 56.7 2.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Bromodomain PF00439.25 ADV19829.1 - 3.4e-42 142.4 4.0 1.7e-21 76.1 0.2 2.4 2 0 0 2 2 2 2 Bromodomain DUF3421 PF11901.8 ADV19830.1 - 1.7e-34 118.2 5.6 1.8e-25 89.1 1.5 1.8 1 1 1 2 2 2 2 Protein of unknown function (DUF3421) DUF5305 PF17231.2 ADV19831.1 - 0.012 15.0 0.0 0.056 12.9 0.0 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5305) EphA2_TM PF14575.6 ADV19831.1 - 0.029 15.2 0.1 0.15 12.9 0.0 2.3 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain DUF2207 PF09972.9 ADV19831.1 - 0.12 11.2 0.0 0.18 10.6 0.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Syndecan PF01034.20 ADV19831.1 - 0.22 11.4 0.0 0.45 10.5 0.0 1.5 1 0 0 1 1 1 0 Syndecan domain TMEM154 PF15102.6 ADV19831.1 - 6.8 6.6 10.9 3 7.7 6.6 2.9 2 1 0 2 2 2 0 TMEM154 protein family PAT1 PF09770.9 ADV19832.1 - 7.5e-78 262.7 12.6 2.4e-71 241.2 0.2 2.9 1 1 1 2 2 2 2 Topoisomerase II-associated protein PAT1 Zn_clus PF00172.18 ADV19833.1 - 6.8e-09 35.7 8.9 1.1e-08 35.0 8.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ribosomal_S17_N PF16205.5 ADV19834.1 - 5.4e-32 110.0 1.4 1e-31 109.1 1.4 1.5 1 0 0 1 1 1 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.20 ADV19834.1 - 6.2e-26 90.3 0.2 6.2e-26 90.3 0.2 1.7 2 0 0 2 2 2 1 Ribosomal protein S17 DUF410 PF04190.13 ADV19835.1 - 1.1e-50 172.8 0.0 1.4e-50 172.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF410) VPS28 PF03997.12 ADV19836.1 - 7.1e-49 166.0 0.0 5.1e-47 160.0 0.0 2.0 1 1 0 1 1 1 1 VPS28 protein SAD_SRA PF02182.17 ADV19837.1 - 3.8e-42 143.6 0.0 4.4e-42 143.4 0.0 1.1 1 0 0 1 1 1 1 SAD/SRA domain cobW PF02492.19 ADV19838.1 - 4.3e-33 114.4 0.0 5.7e-33 114.0 0.0 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 ADV19838.1 - 0.00045 19.3 1.0 0.0062 15.6 1.0 2.0 1 1 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB MMR_HSR1 PF01926.23 ADV19838.1 - 0.0023 18.0 0.0 0.0045 17.1 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase Pox_A32 PF04665.12 ADV19838.1 - 0.031 13.8 0.0 0.043 13.3 0.0 1.2 1 0 0 1 1 1 0 Poxvirus A32 protein AAA_16 PF13191.6 ADV19838.1 - 0.11 12.9 0.0 0.2 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain DUF2156 PF09924.9 ADV19838.1 - 0.12 11.4 0.0 0.22 10.5 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2156) ABC_tran PF00005.27 ADV19838.1 - 0.15 12.6 0.0 0.3 11.6 0.0 1.5 2 0 0 2 2 2 0 ABC transporter DUF4559 PF15112.6 ADV19839.1 - 0.049 13.3 0.8 0.08 12.6 0.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4559) Cnd3 PF12719.7 ADV19840.1 - 2.8e-82 276.2 3.4 2.8e-82 276.2 3.4 2.5 2 1 1 3 3 3 1 Nuclear condensing complex subunits, C-term domain HEAT PF02985.22 ADV19840.1 - 1e-07 31.6 4.5 0.43 11.0 0.1 6.1 7 0 0 7 7 7 3 HEAT repeat Cnd1 PF12717.7 ADV19840.1 - 1.5e-07 31.6 1.3 0.073 13.1 0.0 5.2 4 1 2 6 6 6 3 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 ADV19840.1 - 1.8e-05 25.1 2.4 0.023 15.2 0.5 3.9 3 1 0 3 3 3 2 HEAT-like repeat HEAT_2 PF13646.6 ADV19840.1 - 4.7e-05 23.7 10.7 0.0033 17.8 1.0 4.8 4 1 0 5 5 5 1 HEAT repeats FANCF PF11107.8 ADV19840.1 - 0.041 13.1 0.4 0.31 10.2 0.1 2.2 2 0 0 2 2 2 0 Fanconi anemia group F protein (FANCF) RLL PF10036.9 ADV19840.1 - 0.13 12.1 0.6 14 5.4 0.0 2.9 3 0 0 3 3 3 0 RNA transcription, translation and transport factor protein TPR_5 PF12688.7 ADV19840.1 - 0.17 12.1 2.8 0.27 11.5 0.2 2.5 3 0 0 3 3 3 0 Tetratrico peptide repeat DUF563 PF04577.14 ADV19841.1 - 1.7e-19 70.8 0.0 3.8e-19 69.7 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF563) Kinesin PF00225.23 ADV19842.1 - 2.2e-101 339.1 0.1 4e-101 338.3 0.1 1.4 1 0 0 1 1 1 1 Kinesin motor domain Kinesin_assoc PF16183.5 ADV19842.1 - 1.1e-36 126.6 12.8 1.3e-30 106.8 0.5 3.6 3 1 1 4 4 4 2 Kinesin-associated DUF3694 PF12473.8 ADV19842.1 - 6.6e-31 108.0 0.0 2.1e-30 106.4 0.0 1.9 1 0 0 1 1 1 1 Kinesin protein Microtub_bd PF16796.5 ADV19842.1 - 1.5e-22 80.2 0.0 5.2e-22 78.4 0.0 2.0 2 0 0 2 2 2 1 Microtubule binding PH PF00169.29 ADV19842.1 - 1.3e-09 38.5 0.0 3.8e-09 37.0 0.0 1.8 1 0 0 1 1 1 1 PH domain FHA PF00498.26 ADV19842.1 - 1.7e-05 25.1 0.0 8.2e-05 22.9 0.0 2.2 2 0 0 2 2 2 1 FHA domain KIF1B PF12423.8 ADV19842.1 - 0.0031 17.9 0.1 0.0082 16.6 0.1 1.8 1 0 0 1 1 1 1 Kinesin protein 1B PH_9 PF15410.6 ADV19842.1 - 0.068 13.5 0.0 0.23 11.9 0.0 1.9 1 0 0 1 1 1 0 Pleckstrin homology domain DUF3574 PF12098.8 ADV19842.1 - 0.17 11.7 0.0 0.43 10.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3574) Pkinase PF00069.25 ADV19843.1 - 3.9e-49 167.4 0.1 5.6e-49 166.9 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV19843.1 - 4.6e-18 65.5 0.0 7e-18 64.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase YiiD_C PF09500.10 ADV19843.1 - 0.064 13.1 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 Putative thioesterase (yiiD_Cterm) DEAD PF00270.29 ADV19844.1 - 4.5e-45 153.6 0.0 1.6e-44 151.8 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ADV19844.1 - 4.8e-27 94.5 0.0 4e-26 91.5 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ADV19844.1 - 0.0013 18.8 0.0 0.0039 17.2 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF2986 PF11661.8 ADV19844.1 - 0.0072 16.8 4.6 0.021 15.3 4.6 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF2986) MAP7 PF05672.11 ADV19845.1 - 0.55 9.9 43.1 0.14 11.9 36.4 2.4 2 0 0 2 2 2 0 MAP7 (E-MAP-115) family Spem1 PF15670.5 ADV19845.1 - 7.8 6.0 10.9 0.72 9.4 4.3 2.5 2 0 0 2 2 2 0 Spermatid maturation protein 1 Glycos_transf_1 PF00534.20 ADV19846.1 - 4.3e-05 23.1 0.0 9.5e-05 22.0 0.0 1.5 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ADV19846.1 - 0.00026 21.4 0.0 0.00066 20.1 0.0 1.6 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 ADV19846.1 - 0.0058 17.0 0.0 0.013 15.9 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 ADV19846.1 - 0.03 14.3 0.3 0.056 13.5 0.3 1.4 1 0 0 1 1 1 0 Glycosyltransferase Family 4 Methyltransf_16 PF10294.9 ADV19847.1 - 0.00073 19.3 0.0 0.036 13.8 0.0 2.3 2 0 0 2 2 2 1 Lysine methyltransferase DUF4479 PF14794.6 ADV19847.1 - 0.043 13.7 0.0 0.083 12.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4479) Methyltransf_25 PF13649.6 ADV19847.1 - 0.13 12.9 0.0 24 5.7 0.0 2.8 2 0 0 2 2 2 0 Methyltransferase domain A_thal_3526 PF09713.10 ADV19847.1 - 0.22 11.8 0.1 0.81 10.0 0.1 1.8 2 0 0 2 2 2 0 Plant protein 1589 of unknown function (A_thal_3526) DAO PF01266.24 ADV19848.1 - 5.3e-58 197.3 0.1 6.3e-58 197.0 0.1 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ADV19848.1 - 2.8e-05 23.5 0.3 0.0004 19.7 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ADV19848.1 - 0.00034 21.1 0.7 0.0011 19.4 0.2 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase G-patch PF01585.23 ADV19848.1 - 0.004 17.0 0.6 0.0099 15.7 0.6 1.7 1 0 0 1 1 1 1 G-patch domain NAD_binding_8 PF13450.6 ADV19848.1 - 0.014 15.6 0.3 0.027 14.7 0.3 1.5 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 ADV19848.1 - 0.084 12.9 0.6 0.21 11.6 0.1 1.8 2 0 0 2 2 2 0 FAD-NAD(P)-binding FAD_oxidored PF12831.7 ADV19848.1 - 0.15 11.4 0.5 0.72 9.1 0.2 1.9 2 0 0 2 2 2 0 FAD dependent oxidoreductase WD40 PF00400.32 ADV19849.1 - 7.7e-41 137.3 22.3 1.4e-05 25.7 0.1 8.1 8 0 0 8 8 8 7 WD domain, G-beta repeat F-box-like PF12937.7 ADV19849.1 - 9.3e-11 41.5 0.0 2e-10 40.4 0.0 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ADV19849.1 - 9.9e-09 34.9 1.0 2.1e-08 33.8 0.1 2.1 2 0 0 2 2 2 1 F-box domain ANAPC4_WD40 PF12894.7 ADV19849.1 - 6.6e-08 32.7 2.2 0.45 10.9 0.1 5.8 2 2 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain F-box_4 PF15966.5 ADV19849.1 - 0.11 12.4 0.0 0.27 11.1 0.0 1.6 1 0 0 1 1 1 0 F-box Nup160 PF11715.8 ADV19849.1 - 0.12 11.0 7.5 5.2 5.6 0.1 4.2 2 2 2 5 5 5 0 Nucleoporin Nup120/160 HAT PF02184.16 ADV19850.1 - 4e-23 81.0 46.7 8.8e-08 32.0 0.3 13.3 14 1 0 14 14 14 5 HAT (Half-A-TPR) repeat TPR_14 PF13428.6 ADV19850.1 - 4.7e-20 70.6 39.5 0.0058 17.4 0.0 13.2 6 3 8 14 14 14 6 Tetratricopeptide repeat Suf PF05843.14 ADV19850.1 - 1.4e-13 51.5 15.4 0.00016 21.8 0.6 6.5 4 2 1 5 5 5 3 Suppressor of forked protein (Suf) TPR_19 PF14559.6 ADV19850.1 - 2.5e-10 40.7 8.2 0.029 14.9 0.0 7.4 6 2 0 7 7 6 1 Tetratricopeptide repeat TPR_2 PF07719.17 ADV19850.1 - 1.4e-09 37.3 17.2 0.13 12.5 0.0 9.3 12 0 0 12 12 10 2 Tetratricopeptide repeat TPR_17 PF13431.6 ADV19850.1 - 8.4e-08 32.1 6.8 0.0088 16.4 0.2 6.9 6 2 1 7 7 5 1 Tetratricopeptide repeat TPR_12 PF13424.6 ADV19850.1 - 5.4e-06 26.6 3.2 0.05 13.9 0.0 5.5 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_1 PF00515.28 ADV19850.1 - 5e-05 22.9 0.1 12 5.9 0.0 6.1 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_11 PF13414.6 ADV19850.1 - 6.1e-05 22.6 0.0 1.1 9.0 0.0 4.9 4 0 0 4 4 4 1 TPR repeat TPR_8 PF13181.6 ADV19850.1 - 8.1e-05 22.5 0.2 5 7.6 0.0 6.8 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_15 PF13429.6 ADV19850.1 - 0.00013 21.2 25.1 0.05 12.8 0.1 5.3 2 2 2 5 5 5 3 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 ADV19850.1 - 0.00017 21.5 21.0 0.095 12.7 1.4 6.7 5 3 1 6 6 6 2 Mad3/BUB1 homology region 1 TPR_7 PF13176.6 ADV19850.1 - 0.00027 20.7 9.1 2.4 8.4 0.1 6.5 7 0 0 7 7 5 1 Tetratricopeptide repeat SNAP PF14938.6 ADV19850.1 - 0.00055 19.4 3.4 0.0041 16.6 0.3 3.2 3 0 0 3 3 3 1 Soluble NSF attachment protein, SNAP TPR_16 PF13432.6 ADV19850.1 - 0.0016 19.0 25.5 0.17 12.5 0.0 8.7 8 3 1 9 9 8 1 Tetratricopeptide repeat FAT PF02259.23 ADV19850.1 - 0.021 14.1 7.5 0.34 10.1 0.6 4.1 3 1 1 4 4 4 0 FAT domain QIL1 PF15884.5 ADV19850.1 - 0.17 12.5 1.4 1 10.0 0.1 2.7 2 0 0 2 2 2 0 MICOS complex subunit MIC13, QIL1 U3_assoc_6 PF08640.11 ADV19850.1 - 0.6 10.2 12.5 0.18 11.9 0.5 5.0 4 3 2 6 6 5 0 U3 small nucleolar RNA-associated protein 6 c-SKI_SMAD_bind PF08782.10 ADV19850.1 - 2.4 8.4 3.9 5.5 7.3 0.5 3.1 3 0 0 3 3 3 0 c-SKI Smad4 binding domain DUF3836 PF12930.7 ADV19850.1 - 2.4 7.9 8.9 3.7 7.3 0.4 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF3836) TPR_6 PF13174.6 ADV19850.1 - 5.7 7.8 25.6 30 5.5 0.0 9.0 10 1 0 10 10 9 0 Tetratricopeptide repeat Glyco_hydro_38N PF01074.22 ADV19851.1 - 5.8e-76 255.6 0.1 1e-75 254.8 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 ADV19851.1 - 2e-44 152.2 0.0 3.6e-44 151.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 ADV19851.1 - 5.7e-25 87.3 0.0 1.5e-24 86.0 0.0 1.8 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro38C2 PF17677.1 ADV19851.1 - 2.3e-08 34.0 0.1 6.8e-08 32.5 0.1 1.9 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain Adeno_E3_CR2 PF02439.15 ADV19852.1 - 0.2 11.5 0.3 0.35 10.7 0.3 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 AICARFT_IMPCHas PF01808.18 ADV19853.1 - 1.5e-89 300.4 0.0 1.8e-89 300.1 0.0 1.1 1 0 0 1 1 1 1 AICARFT/IMPCHase bienzyme MGS PF02142.22 ADV19853.1 - 2.1e-24 85.5 0.0 4.4e-24 84.5 0.0 1.6 1 0 0 1 1 1 1 MGS-like domain DUF563 PF04577.14 ADV19854.1 - 6.4e-21 75.5 0.0 9.2e-21 74.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF563) RRM_1 PF00076.22 ADV19855.1 - 5.4e-16 58.2 2.7 0.00019 21.2 0.1 4.5 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) UDG PF03167.19 ADV19856.1 - 4.2e-21 75.5 0.0 1.7e-20 73.6 0.0 1.8 1 1 0 1 1 1 1 Uracil DNA glycosylase superfamily Gln-synt_C PF00120.24 ADV19857.1 - 9.7e-76 255.0 0.0 3.7e-75 253.1 0.0 1.8 1 1 0 1 1 1 1 Glutamine synthetase, catalytic domain Mpv17_PMP22 PF04117.12 ADV19858.1 - 4.7e-16 58.8 1.4 1e-15 57.7 1.4 1.6 1 0 0 1 1 1 1 Mpv17 / PMP22 family TIP49 PF06068.13 ADV19859.1 - 3.5e-156 519.8 0.9 4.3e-156 519.5 0.9 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 ADV19859.1 - 4.9e-22 77.8 0.0 1.4e-21 76.4 0.0 1.8 1 0 0 1 1 1 1 TIP49 AAA-lid domain AAA PF00004.29 ADV19859.1 - 1.3e-08 35.3 0.2 2.4e-05 24.8 0.1 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 ADV19859.1 - 1.2e-07 31.6 0.4 0.0006 19.6 0.0 2.4 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain DnaB_C PF03796.15 ADV19859.1 - 0.00015 21.2 0.5 0.00028 20.3 0.5 1.4 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_22 PF13401.6 ADV19859.1 - 0.00019 21.7 0.1 0.59 10.4 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 ADV19859.1 - 0.00025 21.5 0.2 0.00094 19.6 0.2 1.9 1 1 0 1 1 1 1 AAA ATPase domain Mg_chelatase PF01078.21 ADV19859.1 - 0.00032 20.1 1.6 0.0062 16.0 0.3 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 ADV19859.1 - 0.00074 19.5 0.4 0.32 11.0 0.0 2.9 2 2 0 2 2 2 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 ADV19859.1 - 0.0098 15.6 0.1 5.9 6.6 0.1 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain Parvo_NS1 PF01057.17 ADV19859.1 - 0.013 14.6 0.0 0.031 13.4 0.0 1.6 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 AAA_28 PF13521.6 ADV19859.1 - 0.013 15.7 0.1 0.034 14.4 0.1 1.7 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 ADV19859.1 - 0.017 15.5 2.0 0.45 10.8 2.0 2.5 1 1 0 1 1 1 0 AAA domain PIF1 PF05970.14 ADV19859.1 - 0.024 13.8 0.2 0.93 8.6 0.1 2.2 2 0 0 2 2 2 0 PIF1-like helicase AAA_25 PF13481.6 ADV19859.1 - 0.033 13.8 0.1 0.091 12.3 0.1 1.7 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 ADV19859.1 - 0.043 13.9 0.0 5.2 7.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 ADV19859.1 - 0.049 13.8 0.0 0.12 12.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 ADV19859.1 - 0.069 12.4 0.1 0.39 10.0 0.1 2.0 2 0 0 2 2 2 0 Zeta toxin IstB_IS21 PF01695.17 ADV19859.1 - 0.11 12.2 0.0 0.22 11.2 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein Pox_A_type_inc PF04508.12 ADV19860.1 - 0.009 15.8 0.5 0.13 12.2 0.1 3.0 2 0 0 2 2 2 1 Viral A-type inclusion protein repeat Baculo_PEP_C PF04513.12 ADV19860.1 - 0.019 15.0 0.8 0.019 15.0 0.8 4.5 7 0 0 7 7 7 0 Baculovirus polyhedron envelope protein, PEP, C terminus PRESAN PF09687.10 ADV19860.1 - 0.17 12.4 2.1 1.4 9.5 1.0 2.7 2 0 0 2 2 2 0 Plasmodium RESA N-terminal TSC22 PF01166.18 ADV19860.1 - 0.47 10.8 5.9 12 6.3 0.1 4.0 3 0 0 3 3 3 0 TSC-22/dip/bun family NPV_P10 PF05531.12 ADV19860.1 - 1.4 9.4 23.7 0.19 12.2 0.6 6.6 7 1 0 7 7 7 0 Nucleopolyhedrovirus P10 protein Ribosomal_L31e PF01198.19 ADV19861.1 - 7.9e-40 135.0 0.6 1.1e-39 134.5 0.6 1.2 1 0 0 1 1 1 1 Ribosomal protein L31e QSregVF PF13652.6 ADV19861.1 - 0.079 13.0 0.0 0.18 11.9 0.0 1.6 1 1 1 2 2 2 0 Putative quorum-sensing-regulated virulence factor IF2_N PF04760.15 ADV19861.1 - 0.12 12.2 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region WSC PF01822.19 ADV19864.1 - 3.8e-129 421.2 191.5 3e-18 65.8 15.7 9.9 10 0 0 10 10 10 9 WSC domain DUF1996 PF09362.10 ADV19864.1 - 4.7e-63 213.3 1.4 1.4e-62 211.8 1.4 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) SOG2 PF10428.9 ADV19864.1 - 2 7.5 27.5 3.9 6.6 27.5 1.4 1 0 0 1 1 1 0 RAM signalling pathway protein DAP_epimerase PF01678.19 ADV19864.1 - 8.5 6.6 7.8 25 5.1 0.4 2.6 2 0 0 2 2 2 0 Diaminopimelate epimerase GDP_Man_Dehyd PF16363.5 ADV19865.1 - 6.6e-47 160.5 0.0 1.1e-46 159.8 0.0 1.4 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 ADV19865.1 - 3.9e-43 147.6 0.0 5.6e-43 147.1 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ADV19865.1 - 4.9e-15 55.3 0.0 1.3e-13 50.6 0.0 2.0 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 ADV19865.1 - 4.2e-12 45.8 0.0 6.8e-11 41.8 0.0 2.5 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 ADV19865.1 - 2.2e-11 43.4 0.0 4.1e-11 42.5 0.0 1.4 1 1 0 1 1 1 1 RmlD substrate binding domain KR PF08659.10 ADV19865.1 - 1.6e-06 28.2 0.0 2.8e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_4 PF07993.12 ADV19865.1 - 0.00024 20.4 0.0 0.00088 18.5 0.0 1.9 1 1 0 1 1 1 1 Male sterility protein adh_short PF00106.25 ADV19865.1 - 0.0026 17.3 0.0 0.0052 16.3 0.0 1.6 1 1 0 1 1 1 1 short chain dehydrogenase F-box-like PF12937.7 ADV19866.1 - 0.0016 18.3 0.3 0.0075 16.1 0.3 2.2 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.7 ADV19866.1 - 0.78 10.2 11.0 0.71 10.4 0.6 4.8 3 3 1 4 4 4 0 Leucine Rich repeats (2 copies) SARAF PF06682.12 ADV19867.1 - 0.14 11.8 4.6 0.043 13.5 1.3 1.8 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis PHO4 PF01384.20 ADV19867.1 - 0.21 10.6 6.2 1.3 8.0 7.4 1.4 1 1 0 1 1 1 0 Phosphate transporter family LRR19-TM PF15176.6 ADV19867.1 - 0.24 11.4 0.6 0.91 9.6 0.0 2.2 2 0 0 2 2 2 0 Leucine-rich repeat family 19 TM domain FA_desaturase PF00487.24 ADV19867.1 - 6.5 6.5 6.9 5.4 6.8 0.4 2.2 1 1 1 2 2 2 0 Fatty acid desaturase 4HBT PF03061.22 ADV19868.1 - 3.3e-13 49.8 0.1 5.3e-13 49.1 0.1 1.3 1 0 0 1 1 1 1 Thioesterase superfamily DUF4442 PF14539.6 ADV19868.1 - 0.022 14.9 0.0 0.034 14.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4442) Borrelia_P83 PF05262.11 ADV19869.1 - 0.036 12.6 0.1 0.042 12.3 0.1 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein Tim17 PF02466.19 ADV19869.1 - 0.069 13.5 0.9 0.48 10.8 0.0 2.3 2 1 0 2 2 2 0 Tim17/Tim22/Tim23/Pmp24 family DUF4366 PF14283.6 ADV19869.1 - 0.1 12.6 0.3 0.44 10.6 0.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) DUF5353 PF17304.2 ADV19869.1 - 0.16 11.7 10.1 0.24 11.2 0.6 2.6 2 1 0 2 2 2 0 Family of unknown function (DUF5353) NCE101 PF11654.8 ADV19869.1 - 0.21 11.3 1.6 5.1 6.9 0.0 3.0 2 1 1 3 3 3 0 Non-classical export protein 1 Ribul_P_3_epim PF00834.19 ADV19870.1 - 9.1e-63 211.2 0.0 1.1e-62 211.0 0.0 1.1 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family ThiG PF05690.14 ADV19870.1 - 0.0077 15.6 0.0 0.012 14.9 0.0 1.3 1 0 0 1 1 1 1 Thiazole biosynthesis protein ThiG PcrB PF01884.17 ADV19870.1 - 0.024 14.1 0.1 0.34 10.3 0.0 2.0 2 0 0 2 2 2 0 PcrB family HSP70 PF00012.20 ADV19870.1 - 0.04 12.1 0.1 0.055 11.7 0.1 1.2 1 0 0 1 1 1 0 Hsp70 protein DHR10 PF18595.1 ADV19871.1 - 1.4e-20 73.4 20.7 1.4e-20 73.4 20.7 3.9 2 1 2 4 4 4 2 Designed helical repeat protein 10 domain Nuf2 PF03800.14 ADV19871.1 - 1.4e-19 70.6 0.4 1.4e-19 70.6 0.4 2.3 2 1 1 3 3 3 1 Nuf2 family SHE3 PF17078.5 ADV19871.1 - 0.99 9.1 35.5 0.015 15.0 14.0 2.9 1 1 1 2 2 2 0 SWI5-dependent HO expression protein 3 GAS PF13851.6 ADV19871.1 - 4.2 6.7 51.6 0.84 8.9 17.9 3.4 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding Mito_carr PF00153.27 ADV19872.1 - 9.4e-57 188.9 3.4 3.8e-20 71.6 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 ADV19872.1 - 0.25 10.4 0.9 17 4.4 0.0 3.0 4 0 0 4 4 4 0 Gammaproteobacterial serine protease GCV_T_C PF08669.11 ADV19873.1 - 0.15 12.0 0.0 0.35 10.8 0.0 1.5 1 0 0 1 1 1 0 Glycine cleavage T-protein C-terminal barrel domain Tcf25 PF04910.14 ADV19874.1 - 2.9e-104 348.9 0.0 3.8e-104 348.5 0.0 1.1 1 0 0 1 1 1 1 Transcriptional repressor TCF25 TPR_12 PF13424.6 ADV19874.1 - 0.1 12.9 0.5 2 8.8 0.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat RNA_polI_A34 PF08208.11 ADV19874.1 - 0.17 12.0 10.1 0.35 10.9 10.1 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Rsa3 PF14615.6 ADV19875.1 - 0.025 14.1 0.0 0.039 13.5 0.0 1.2 1 0 0 1 1 1 0 Ribosome-assembly protein 3 AF-4 PF05110.13 ADV19875.1 - 0.067 11.3 33.5 0.074 11.1 33.5 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein SDA1 PF05285.12 ADV19875.1 - 0.14 11.6 9.8 0.15 11.4 9.8 1.1 1 0 0 1 1 1 0 SDA1 Cwf_Cwc_15 PF04889.12 ADV19875.1 - 0.36 10.5 15.1 0.61 9.8 15.1 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Nop14 PF04147.12 ADV19875.1 - 0.41 8.8 8.7 0.45 8.7 8.7 1.0 1 0 0 1 1 1 0 Nop14-like family DUF4050 PF13259.6 ADV19875.1 - 0.8 10.0 9.8 1.2 9.5 9.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) PNISR PF15996.5 ADV19875.1 - 1.3 9.3 9.1 1.6 9.0 9.1 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR NST1 PF13945.6 ADV19875.1 - 2.1 8.4 10.1 1.6 8.8 3.5 2.0 1 1 1 2 2 2 0 Salt tolerance down-regulator Apt1 PF10351.9 ADV19875.1 - 2.6 6.8 15.5 3.1 6.5 15.5 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Macoilin PF09726.9 ADV19875.1 - 3.2 6.2 12.2 3.3 6.1 12.2 1.1 1 0 0 1 1 1 0 Macoilin family Lin-8 PF03353.15 ADV19875.1 - 3.7 7.0 6.1 4.6 6.7 6.1 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist SPX PF03105.19 ADV19875.1 - 4.3 7.2 21.8 5.1 6.9 21.8 1.0 1 0 0 1 1 1 0 SPX domain BUD22 PF09073.10 ADV19875.1 - 4.3 6.6 23.3 5.5 6.2 23.3 1.1 1 0 0 1 1 1 0 BUD22 Presenilin PF01080.17 ADV19875.1 - 7.3 5.2 9.5 7.7 5.2 9.5 1.1 1 0 0 1 1 1 0 Presenilin Plasmodium_Vir PF05795.11 ADV19875.1 - 7.4 5.9 8.3 9.5 5.5 8.3 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Mid2 PF04478.12 ADV19876.1 - 0.0049 16.7 0.1 0.011 15.6 0.1 1.5 1 0 0 1 1 1 1 Mid2 like cell wall stress sensor Adeno_E3_CR2 PF02439.15 ADV19876.1 - 0.0072 16.1 0.0 0.016 14.9 0.0 1.5 1 0 0 1 1 1 1 Adenovirus E3 region protein CR2 Yip1 PF04893.17 ADV19876.1 - 0.0096 15.7 0.3 0.016 14.9 0.3 1.4 1 0 0 1 1 1 1 Yip1 domain DUF1206 PF06724.11 ADV19876.1 - 0.01 15.9 1.1 0.01 15.9 1.1 3.1 3 0 0 3 3 3 0 Domain of Unknown Function (DUF1206) SKG6 PF08693.10 ADV19876.1 - 0.02 14.3 1.0 0.02 14.3 1.0 1.8 2 0 0 2 2 2 0 Transmembrane alpha-helix domain Apt1 PF10351.9 ADV19876.1 - 1 8.2 5.3 1.3 7.8 5.3 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain DLH PF01738.18 ADV19879.1 - 3.6e-20 72.5 0.0 4.3e-20 72.2 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Hist_deacetyl PF00850.19 ADV19880.1 - 3.8e-42 144.8 0.0 7.2e-42 143.9 0.0 1.4 1 0 0 1 1 1 1 Histone deacetylase domain TSP_NTD PF17804.1 ADV19880.1 - 0.19 12.0 0.0 0.4 10.9 0.0 1.4 1 0 0 1 1 1 0 Tail specific protease N-terminal domain Ima1_N PF09779.9 ADV19881.1 - 4.8e-28 98.7 2.0 1.6e-27 97.0 0.5 2.1 2 0 0 2 2 2 1 Ima1 N-terminal domain MtN3_slv PF03083.16 ADV19881.1 - 0.0048 16.9 0.2 0.017 15.1 0.2 2.0 1 1 0 1 1 1 1 Sugar efflux transporter for intercellular exchange DUF1244 PF06844.11 ADV19881.1 - 0.13 12.4 0.8 3.3 8.0 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1244) zf-NPL4 PF05020.15 ADV19882.1 - 0.082 13.0 0.2 0.18 11.9 0.2 1.5 1 0 0 1 1 1 0 NPL4 family, putative zinc binding region Ribosomal_60s PF00428.19 ADV19883.1 - 1.7e-27 95.8 9.4 2.5e-27 95.3 9.4 1.2 1 0 0 1 1 1 1 60s Acidic ribosomal protein DUF5572 PF17733.1 ADV19884.1 - 1.6e-09 37.4 0.1 3.8e-09 36.2 0.1 1.7 1 0 0 1 1 1 1 Family of unknown function (DUF5572) MatP_C PF17414.2 ADV19884.1 - 0.17 12.1 0.0 0.29 11.3 0.0 1.4 1 0 0 1 1 1 0 MatP C-terminal ribbon-helix-helix domain ABC_membrane_2 PF06472.15 ADV19885.1 - 1.3e-72 244.5 2.6 5.4e-46 157.2 0.0 3.1 2 1 0 2 2 2 2 ABC transporter transmembrane region 2 ABC_tran PF00005.27 ADV19885.1 - 2.1e-14 54.2 0.0 7.2e-14 52.5 0.0 2.0 2 0 0 2 2 2 1 ABC transporter AAA_23 PF13476.6 ADV19885.1 - 0.00017 22.1 1.4 0.027 15.0 0.0 2.3 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.12 ADV19885.1 - 0.0002 21.1 0.0 0.00047 19.9 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_21 PF13304.6 ADV19885.1 - 0.0043 16.9 0.0 0.0098 15.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 ADV19885.1 - 0.015 15.7 0.0 0.045 14.1 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain AAA PF00004.29 ADV19885.1 - 0.016 15.7 0.0 0.037 14.5 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 ADV19885.1 - 0.036 13.8 0.0 0.078 12.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.6 ADV19885.1 - 0.042 14.1 0.0 0.12 12.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 ADV19885.1 - 0.042 13.8 0.0 0.09 12.7 0.0 1.6 1 0 0 1 1 1 0 NACHT domain SMC_N PF02463.19 ADV19885.1 - 0.043 13.2 0.0 1.4 8.3 0.0 2.2 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain Sigma54_activat PF00158.26 ADV19885.1 - 0.081 12.6 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_18 PF13238.6 ADV19885.1 - 0.15 12.6 0.0 0.39 11.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 ADV19885.1 - 0.19 11.5 0.1 12 5.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain DUF3584 PF12128.8 ADV19885.1 - 0.35 8.3 4.1 0.28 8.7 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) Trp_syntA PF00290.20 ADV19886.1 - 5.4e-85 284.4 0.5 5.4e-85 284.4 0.5 2.0 2 0 0 2 2 2 1 Tryptophan synthase alpha chain PALP PF00291.25 ADV19886.1 - 1e-46 159.7 0.3 2.1e-46 158.7 0.0 1.5 2 0 0 2 2 2 1 Pyridoxal-phosphate dependent enzyme His_biosynth PF00977.21 ADV19886.1 - 0.00061 19.3 0.0 0.0014 18.2 0.0 1.5 1 0 0 1 1 1 1 Histidine biosynthesis protein Hydrolase_4 PF12146.8 ADV19887.1 - 1.3e-13 50.8 0.0 1.6e-13 50.5 0.0 1.0 1 0 0 1 1 1 1 Serine aminopeptidase, S33 RhoGAP PF00620.27 ADV19888.1 - 7.6e-25 87.5 0.0 1.8e-24 86.3 0.0 1.7 1 0 0 1 1 1 1 RhoGAP domain MyTH4 PF00784.17 ADV19888.1 - 4.7e-21 75.3 0.0 9.6e-21 74.3 0.0 1.5 1 0 0 1 1 1 1 MyTH4 domain FA_desaturase PF00487.24 ADV19889.1 - 4.6e-25 88.9 20.1 4.8e-25 88.8 19.1 1.5 1 1 1 2 2 2 1 Fatty acid desaturase Lipid_DES PF08557.10 ADV19889.1 - 8.5e-18 63.6 1.1 1.4e-17 62.9 0.3 1.8 2 0 0 2 2 2 1 Sphingolipid Delta4-desaturase (DES) DUF3168 PF11367.8 ADV19889.1 - 0.044 14.0 0.0 0.67 10.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3168) PUNUT PF16913.5 ADV19889.1 - 0.2 10.8 1.8 0.24 10.6 0.1 1.8 2 0 0 2 2 2 0 Purine nucleobase transmembrane transport Phosducin PF02114.16 ADV19890.1 - 3e-13 49.4 0.2 9.9e-09 34.5 0.4 2.1 1 1 1 2 2 2 2 Phosducin Cytochrom_C PF00034.21 ADV19891.1 - 1.5e-09 38.9 0.1 1.7e-09 38.7 0.1 1.1 1 0 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 ADV19891.1 - 4.7e-06 26.8 1.4 7e-06 26.3 1.4 1.3 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.6 ADV19891.1 - 0.0017 18.0 0.2 0.0035 17.0 0.2 1.7 1 1 0 1 1 1 1 Cytochrome c-550 domain CUE PF02845.16 ADV19892.1 - 8.8e-08 31.7 0.0 1.7e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 CUE domain DMA PF03474.14 ADV19892.1 - 9e-06 25.2 0.0 1.6e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 DMRTA motif Rad51 PF08423.11 ADV19893.1 - 6.9e-124 412.2 0.0 8.3e-124 411.9 0.0 1.1 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.6 ADV19893.1 - 4.7e-08 32.8 0.0 7.2e-08 32.2 0.0 1.2 1 0 0 1 1 1 1 AAA domain HHH_5 PF14520.6 ADV19893.1 - 5.1e-08 33.4 0.1 1.5e-07 31.9 0.1 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix domain ATPase PF06745.13 ADV19893.1 - 0.0013 18.1 0.1 0.0027 17.1 0.1 1.6 1 1 0 1 1 1 1 KaiC HHH PF00633.23 ADV19893.1 - 0.1 12.5 0.0 0.27 11.2 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix motif DnaB_C PF03796.15 ADV19893.1 - 0.11 11.9 0.0 0.23 10.8 0.0 1.5 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain ssDNA_TraI_N PF18272.1 ADV19893.1 - 0.13 12.3 0.2 0.32 11.0 0.2 1.6 1 0 0 1 1 1 0 single-stranded DNA binding TraI N-terminal subdomain PAXNEB PF05625.11 ADV19893.1 - 2.4 7.2 3.9 5.6 6.0 2.1 2.0 1 1 1 2 2 2 0 PAXNEB protein CAP59_mtransfer PF11735.8 ADV19894.1 - 1.1e-68 231.5 0.0 1.5e-68 231.1 0.0 1.2 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 ABC2_membrane PF01061.24 ADV19896.1 - 7.5e-73 244.4 59.3 8.3e-43 146.3 27.1 3.6 4 0 0 4 4 4 2 ABC-2 type transporter ABC_tran PF00005.27 ADV19896.1 - 3.8e-35 121.4 0.0 2.6e-18 66.8 0.0 2.7 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 ADV19896.1 - 5.6e-28 96.7 3.4 8.5e-26 89.7 0.1 4.2 4 0 0 4 4 3 2 CDR ABC transporter ABC_trans_N PF14510.6 ADV19896.1 - 2.2e-07 31.4 0.6 7.5e-07 29.7 0.6 2.0 1 0 0 1 1 1 1 ABC-transporter N-terminal AAA_18 PF13238.6 ADV19896.1 - 5.6e-05 23.7 0.0 0.00015 22.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain ABC2_membrane_3 PF12698.7 ADV19896.1 - 0.0001 21.5 20.6 0.0001 21.5 20.6 3.0 3 0 0 3 3 3 2 ABC-2 family transporter protein AAA_21 PF13304.6 ADV19896.1 - 0.00011 22.2 0.0 0.31 10.8 0.1 2.5 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_25 PF13481.6 ADV19896.1 - 0.0012 18.4 0.1 0.018 14.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 ADV19896.1 - 0.0013 18.7 0.0 0.0026 17.7 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_33 PF13671.6 ADV19896.1 - 0.0033 17.6 0.0 0.011 15.9 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 ADV19896.1 - 0.0034 17.1 0.4 0.017 14.8 0.4 2.1 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_16 PF13191.6 ADV19896.1 - 0.0056 17.1 0.0 0.023 15.1 0.0 2.1 1 0 0 1 1 1 1 AAA ATPase domain SMC_N PF02463.19 ADV19896.1 - 0.039 13.4 0.4 11 5.4 0.0 3.4 4 0 0 4 4 4 0 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 ADV19896.1 - 0.044 13.9 0.1 16 5.6 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase cobW PF02492.19 ADV19896.1 - 0.049 13.2 0.4 0.14 11.8 0.1 1.8 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_28 PF13521.6 ADV19896.1 - 0.059 13.6 0.0 0.15 12.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 ADV19896.1 - 0.08 13.2 0.6 0.69 10.2 0.0 2.7 3 0 0 3 3 2 0 AAA domain PDR_assoc PF08370.11 ADV19896.1 - 7.5 6.4 9.5 0.45 10.3 2.0 2.9 2 0 0 2 2 2 0 Plant PDR ABC transporter associated NAD_binding_8 PF13450.6 ADV19898.1 - 4e-14 52.6 0.0 9e-14 51.5 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 ADV19898.1 - 4e-09 36.5 0.3 2.5e-06 27.3 0.0 2.5 2 1 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 ADV19898.1 - 1.7e-06 27.5 0.0 2.7e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Amino_oxidase PF01593.24 ADV19898.1 - 1.7e-05 24.3 0.0 0.012 15.0 0.0 2.7 3 0 0 3 3 3 2 Flavin containing amine oxidoreductase Pyr_redox_2 PF07992.14 ADV19898.1 - 3.5e-05 23.2 0.0 0.00033 20.0 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 ADV19898.1 - 9.3e-05 21.7 0.0 0.00015 21.0 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 ADV19898.1 - 0.00027 21.5 0.0 0.001 19.5 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 ADV19898.1 - 0.00039 19.7 0.0 0.00063 19.1 0.0 1.3 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.14 ADV19898.1 - 0.0015 17.3 0.0 0.0079 14.9 0.0 1.9 2 0 0 2 2 2 1 HI0933-like protein GIDA PF01134.22 ADV19898.1 - 0.0019 17.3 0.0 0.0066 15.6 0.0 1.8 2 0 0 2 2 2 1 Glucose inhibited division protein A 3HCDH_N PF02737.18 ADV19898.1 - 0.0023 17.8 0.0 0.0038 17.1 0.0 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 ADV19898.1 - 0.0035 16.9 0.0 0.013 15.1 0.0 1.9 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain FAD_oxidored PF12831.7 ADV19898.1 - 0.017 14.5 0.0 0.025 13.9 0.0 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 ADV19898.1 - 0.036 13.1 0.0 0.06 12.4 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein ApbA PF02558.16 ADV19898.1 - 0.081 12.6 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Amidohydro_2 PF04909.14 ADV19899.1 - 2.5e-08 34.0 0.0 3.8e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 Amidohydrolase N2227 PF07942.12 ADV19900.1 - 1.2e-83 280.4 0.0 4e-72 242.7 0.0 2.1 1 1 1 2 2 2 2 N2227-like protein Methyltransf_23 PF13489.6 ADV19900.1 - 0.0095 15.8 0.0 0.04 13.7 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain TPMT PF05724.11 ADV19900.1 - 0.013 15.1 0.0 0.025 14.2 0.0 1.4 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) Methyltransf_12 PF08242.12 ADV19900.1 - 0.068 13.9 0.0 10 6.9 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase domain DEAD PF00270.29 ADV19901.1 - 1.1e-39 136.0 0.2 2.2e-39 135.0 0.2 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ADV19901.1 - 2.8e-29 101.7 0.4 8e-27 93.8 0.1 2.6 3 0 0 3 3 3 2 Helicase conserved C-terminal domain ResIII PF04851.15 ADV19901.1 - 3.7e-09 36.8 0.0 7.5e-09 35.8 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit UvrD-helicase PF00580.21 ADV19901.1 - 0.0006 19.4 0.1 0.00088 18.9 0.1 1.3 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain CMS1 PF14617.6 ADV19901.1 - 0.044 13.1 0.0 0.11 11.8 0.0 1.6 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit DNA_ligase_A_N PF04675.14 ADV19901.1 - 0.15 12.4 1.0 0.92 9.8 0.3 2.1 1 1 1 2 2 2 0 DNA ligase N terminus Aminotran_1_2 PF00155.21 ADV19902.1 - 1.8e-34 119.5 0.0 2.3e-34 119.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 ADV19902.1 - 0.018 13.6 0.0 0.029 12.9 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Pkinase PF00069.25 ADV19903.1 - 1.8e-43 148.8 0.0 5.8e-43 147.1 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV19903.1 - 1.6e-22 80.0 0.0 2.5e-22 79.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ADV19903.1 - 0.014 15.3 0.0 0.043 13.7 0.0 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family DUF2685 PF10886.8 ADV19903.1 - 0.079 13.2 0.1 0.16 12.1 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2685) FTA2 PF13095.6 ADV19903.1 - 0.16 11.6 0.0 12 5.5 0.0 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 ADV19903.1 - 0.24 10.3 0.1 0.39 9.6 0.1 1.2 1 0 0 1 1 1 0 Haspin like kinase domain DUF2633 PF11119.8 ADV19904.1 - 0.19 11.7 0.3 0.37 10.7 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2633) ATP-grasp_2 PF08442.10 ADV19905.1 - 4.6e-72 241.8 0.1 8.8e-72 240.9 0.1 1.5 1 0 0 1 1 1 1 ATP-grasp domain Ligase_CoA PF00549.19 ADV19905.1 - 6.8e-25 87.7 0.3 1.4e-24 86.7 0.3 1.5 1 0 0 1 1 1 1 CoA-ligase ATP-grasp_5 PF13549.6 ADV19905.1 - 2.6e-09 36.9 0.2 9.9e-09 35.0 0.0 1.9 2 0 0 2 2 2 1 ATP-grasp domain GARS_A PF01071.19 ADV19905.1 - 0.00085 19.1 0.0 0.012 15.4 0.1 2.3 1 1 1 2 2 2 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain MFS_1 PF07690.16 ADV19906.1 - 1.1e-33 116.7 20.1 1.8e-33 115.9 20.1 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF4131 PF13567.6 ADV19906.1 - 0.17 11.5 0.1 0.17 11.5 0.1 4.2 3 3 1 4 4 4 0 Domain of unknown function (DUF4131) DUF2834 PF11196.8 ADV19906.1 - 0.25 11.7 3.3 19 5.7 0.8 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF2834) Methyltransf_16 PF10294.9 ADV19907.1 - 1e-43 149.1 0.0 1.3e-43 148.7 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase PrmA PF06325.13 ADV19907.1 - 0.00055 19.4 0.0 0.00085 18.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 ADV19907.1 - 0.0033 17.0 0.0 0.0048 16.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain DivIC PF04977.15 ADV19908.1 - 0.0027 17.5 3.1 0.0044 16.7 3.1 1.3 1 0 0 1 1 1 1 Septum formation initiator Herpes_UL6 PF01763.16 ADV19908.1 - 0.027 13.0 0.2 0.032 12.8 0.2 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like SlyX PF04102.12 ADV19908.1 - 0.058 14.0 4.3 0.39 11.4 3.4 2.2 1 1 1 2 2 2 0 SlyX Fib_alpha PF08702.10 ADV19908.1 - 0.071 13.3 0.9 0.094 12.9 0.9 1.3 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family APG6_N PF17675.1 ADV19908.1 - 0.077 13.5 1.2 0.1 13.1 1.2 1.2 1 0 0 1 1 1 0 Apg6 coiled-coil region CREPT PF16566.5 ADV19908.1 - 0.13 12.4 1.4 0.19 11.9 1.4 1.2 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour ADIP PF11559.8 ADV19908.1 - 0.23 11.6 4.6 0.43 10.6 4.6 1.6 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding ADH_zinc_N PF00107.26 ADV19909.1 - 4.5e-13 49.3 0.0 8.1e-13 48.5 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ADV19909.1 - 4.4e-06 27.8 0.0 7.2e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ADV19909.1 - 0.001 18.9 0.0 0.009 15.9 0.0 2.1 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain WD40 PF00400.32 ADV19910.1 - 1e-17 64.2 19.3 2e-05 25.2 0.0 8.2 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV19910.1 - 1.8e-13 50.6 0.1 0.00035 20.8 0.0 4.3 4 0 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 ADV19910.1 - 1.6e-05 24.6 1.7 7.6e-05 22.4 1.7 2.2 1 1 0 1 1 1 1 PQQ-like domain Nup160 PF11715.8 ADV19910.1 - 0.12 11.0 0.1 0.21 10.2 0.1 1.3 1 0 0 1 1 1 0 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ADV19910.1 - 0.22 10.4 0.0 0.78 8.6 0.0 1.9 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein SLD3 PF08639.10 ADV19911.1 - 3.4e-14 52.5 3.6 3.4e-14 52.5 3.6 4.1 2 2 1 3 3 3 2 DNA replication regulator SLD3 UCH PF00443.29 ADV19912.1 - 8.7e-66 222.0 0.0 1.3e-65 221.5 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ADV19912.1 - 5.9e-22 78.7 0.0 1.2e-19 71.1 0.0 2.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase USP8_dimer PF08969.11 ADV19912.1 - 0.002 18.3 0.1 0.0038 17.4 0.1 1.3 1 0 0 1 1 1 1 USP8 dimerisation domain Kelch_6 PF13964.6 ADV19913.1 - 4.2e-15 55.4 1.7 3.5e-07 30.3 0.1 4.7 4 0 0 4 4 4 3 Kelch motif Kelch_2 PF07646.15 ADV19913.1 - 1.5e-14 53.3 3.9 8.6e-05 22.4 0.5 5.1 5 0 0 5 5 5 2 Kelch motif Kelch_4 PF13418.6 ADV19913.1 - 1.4e-11 44.2 0.9 0.0011 19.0 0.0 4.8 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_5 PF13854.6 ADV19913.1 - 2e-10 40.4 0.1 8.9e-05 22.4 0.1 3.8 3 0 0 3 3 3 2 Kelch motif Kelch_1 PF01344.25 ADV19913.1 - 2.7e-10 39.6 1.0 0.00013 21.4 0.1 4.0 4 0 0 4 4 4 3 Kelch motif Kelch_3 PF13415.6 ADV19913.1 - 3.4e-09 36.8 5.4 5e-07 29.9 0.0 4.5 5 0 0 5 5 5 1 Galactose oxidase, central domain DUF1682 PF07946.14 ADV19913.1 - 0.0025 17.1 1.6 0.0039 16.5 1.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) BTB PF00651.31 ADV19913.1 - 0.11 12.7 0.0 1 9.6 0.0 2.1 1 1 0 1 1 1 0 BTB/POZ domain MTHFR PF02219.17 ADV19914.1 - 3.9e-104 348.0 0.0 5.3e-104 347.6 0.0 1.1 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase Elf1 PF05129.13 ADV19914.1 - 0.13 12.3 0.2 0.27 11.3 0.2 1.5 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like Diphthamide_syn PF01866.17 ADV19915.1 - 3.8e-91 305.7 0.0 2.5e-57 194.6 0.0 2.3 2 1 0 2 2 2 2 Putative diphthamide synthesis protein DEAD PF00270.29 ADV19916.1 - 1.6e-43 148.5 0.0 3e-43 147.6 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ADV19916.1 - 3.6e-24 85.3 0.0 8.9e-24 84.0 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 ADV19916.1 - 3.3e-18 65.6 0.1 7.9e-18 64.4 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 ADV19916.1 - 3.6e-06 27.1 0.1 0.00029 20.9 0.0 2.6 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Pkinase PF00069.25 ADV19917.1 - 4.6e-57 193.4 0.0 5.8e-57 193.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV19917.1 - 5.4e-37 127.5 0.0 7.5e-37 127.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ADV19917.1 - 1.5e-06 27.7 0.0 2.2e-06 27.2 0.0 1.1 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 ADV19917.1 - 0.00087 19.3 0.0 0.0086 16.0 0.0 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ADV19917.1 - 0.017 13.9 0.0 0.029 13.2 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Haspin_kinase PF12330.8 ADV19917.1 - 0.041 12.8 0.0 0.067 12.1 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain UBA PF00627.31 ADV19918.1 - 2.5e-26 91.1 6.4 7.9e-14 51.2 0.2 2.6 2 0 0 2 2 2 2 UBA/TS-N domain XPC-binding PF09280.11 ADV19918.1 - 9.7e-20 70.1 2.3 1.7e-19 69.3 2.3 1.4 1 0 0 1 1 1 1 XPC-binding domain ubiquitin PF00240.23 ADV19918.1 - 3.7e-15 55.4 0.2 6e-15 54.8 0.2 1.3 1 0 0 1 1 1 1 Ubiquitin family UBA_3 PF09288.10 ADV19918.1 - 2.1e-06 27.5 0.0 0.0024 17.6 0.0 2.4 2 0 0 2 2 2 2 Fungal ubiquitin-associated domain Rad60-SLD PF11976.8 ADV19918.1 - 1e-05 25.2 0.5 1.7e-05 24.5 0.5 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like WIYLD PF10440.9 ADV19918.1 - 0.0062 16.3 0.1 1 9.2 0.0 2.4 2 0 0 2 2 2 1 Ubiquitin-binding WIYLD domain DUF2407 PF10302.9 ADV19918.1 - 0.0089 16.6 0.0 0.016 15.8 0.0 1.3 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.6 ADV19918.1 - 0.052 13.7 0.0 0.097 12.8 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Herpes_U47 PF05467.11 ADV19918.1 - 0.15 10.2 4.4 0.22 9.6 4.4 1.3 1 0 0 1 1 1 0 Herpesvirus glycoprotein U47 FAP PF07174.11 ADV19918.1 - 0.96 8.8 57.2 1.2 8.5 21.7 2.2 2 0 0 2 2 2 0 Fibronectin-attachment protein (FAP) UTP15_C PF09384.10 ADV19920.1 - 2e-46 157.3 0.0 3.2e-46 156.7 0.0 1.3 1 0 0 1 1 1 1 UTP15 C terminal WD40 PF00400.32 ADV19920.1 - 8.6e-24 83.4 9.8 0.00038 21.2 0.0 7.1 6 1 1 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV19920.1 - 4.3e-10 39.7 0.0 0.0088 16.3 0.0 4.5 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 ADV19920.1 - 0.025 13.1 0.1 14 4.1 0.0 3.0 3 0 0 3 3 3 0 Cytochrome D1 heme domain Nup160 PF11715.8 ADV19920.1 - 0.037 12.7 0.0 0.17 10.5 0.0 2.1 2 0 0 2 2 2 0 Nucleoporin Nup120/160 Coatomer_WDAD PF04053.14 ADV19920.1 - 0.13 11.3 0.0 2.3 7.1 0.0 2.0 2 0 0 2 2 2 0 Coatomer WD associated region Ge1_WD40 PF16529.5 ADV19920.1 - 0.14 11.1 1.1 34 3.2 0.1 3.5 2 2 2 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PALB2_WD40 PF16756.5 ADV19920.1 - 0.19 10.6 0.4 12 4.7 0.0 2.5 3 0 0 3 3 3 0 Partner and localizer of BRCA2 WD40 domain PQQ_3 PF13570.6 ADV19920.1 - 2.4 8.8 4.3 13 6.4 0.2 3.2 3 0 0 3 3 3 0 PQQ-like domain PH PF00169.29 ADV19922.1 - 7.9e-07 29.5 0.0 3.5e-05 24.3 0.0 2.5 2 0 0 2 2 2 1 PH domain ATG13 PF10033.9 ADV19923.1 - 1.9e-43 148.9 0.0 2.7e-43 148.4 0.0 1.2 1 0 0 1 1 1 1 Autophagy-related protein 13 2-Hacid_dh_C PF02826.19 ADV19925.1 - 2e-52 177.1 0.0 3e-52 176.5 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 ADV19925.1 - 2e-35 121.4 0.0 9e-35 119.3 0.0 1.9 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain AdoHcyase_NAD PF00670.21 ADV19925.1 - 0.0032 17.6 0.0 0.0062 16.6 0.0 1.4 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain ACT PF01842.25 ADV19925.1 - 0.0035 17.1 0.0 0.009 15.8 0.0 1.7 1 0 0 1 1 1 1 ACT domain Phage_TAC_7 PF10109.9 ADV19925.1 - 0.0041 17.2 0.0 0.017 15.2 0.0 1.9 2 0 0 2 2 2 1 Phage tail assembly chaperone proteins, E, or 41 or 14 NAD_binding_2 PF03446.15 ADV19925.1 - 0.0089 16.2 0.2 0.024 14.8 0.0 1.8 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase Ribosomal_L29 PF00831.23 ADV19926.1 - 4e-19 68.3 3.1 4e-19 68.3 3.1 1.9 2 1 0 2 2 2 1 Ribosomal L29 protein Annexin PF00191.20 ADV19926.1 - 0.051 13.7 1.1 0.084 12.9 0.1 1.8 2 0 0 2 2 2 0 Annexin NTF2 PF02136.20 ADV19926.1 - 0.18 12.4 0.6 3.2 8.4 0.1 2.0 1 1 1 2 2 2 0 Nuclear transport factor 2 (NTF2) domain MutS_V PF00488.21 ADV19927.1 - 2e-84 282.3 0.0 4.2e-84 281.3 0.0 1.6 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 ADV19927.1 - 4.9e-32 111.7 3.7 5.6e-32 111.5 0.8 2.3 2 0 0 2 2 2 1 MutS domain III MutS_II PF05188.17 ADV19927.1 - 3.3e-17 63.1 1.5 6.7e-17 62.0 0.1 2.2 2 0 0 2 2 2 1 MutS domain II MutS_IV PF05190.18 ADV19927.1 - 2.9e-16 59.6 2.7 8.5e-16 58.1 2.7 1.9 1 0 0 1 1 1 1 MutS family domain IV MutS_I PF01624.20 ADV19927.1 - 1.4e-12 47.9 0.0 3.1e-12 46.7 0.0 1.6 1 0 0 1 1 1 1 MutS domain I CIA30 PF08547.12 ADV19928.1 - 2.1e-13 50.6 0.0 3.9e-13 49.7 0.0 1.4 1 0 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) DUF726 PF05277.12 ADV19929.1 - 1.3e-61 208.5 1.4 3.2e-48 164.4 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF726) Abhydrolase_6 PF12697.7 ADV19929.1 - 0.61 10.6 14.4 0.15 12.6 0.2 2.6 2 1 0 2 2 2 0 Alpha/beta hydrolase family DUF2076 PF09849.9 ADV19929.1 - 1.9 8.5 6.6 0.41 10.6 1.8 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) Plasmodium_Vir PF05795.11 ADV19929.1 - 2.2 7.6 3.6 3.5 6.9 3.6 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein DUF2461 PF09365.10 ADV19931.1 - 4e-63 213.1 0.1 5.3e-63 212.7 0.1 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein (DUF2461) cwf18 PF08315.12 ADV19932.1 - 6.4e-33 114.3 7.9 1.1e-32 113.5 7.9 1.4 1 0 0 1 1 1 1 cwf18 pre-mRNA splicing factor AF-4 PF05110.13 ADV19933.1 - 5.4 5.0 12.4 6.9 4.6 12.4 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DUF1420 PF07220.11 ADV19934.1 - 0.088 11.4 0.7 0.11 11.0 0.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1420) ABC_tran PF00005.27 ADV19935.1 - 1.7e-34 119.2 0.2 6.5e-17 62.3 0.0 3.1 2 1 0 2 2 2 2 ABC transporter RLI PF04068.15 ADV19935.1 - 3.1e-13 49.3 6.1 6.9e-13 48.2 6.1 1.6 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI SMC_N PF02463.19 ADV19935.1 - 4.2e-09 36.2 0.9 0.012 15.1 0.0 3.7 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain Fer4 PF00037.27 ADV19935.1 - 1.5e-08 34.1 3.0 1.5e-08 34.1 3.0 2.3 2 0 0 2 2 2 1 4Fe-4S binding domain AAA_21 PF13304.6 ADV19935.1 - 4.7e-08 33.2 4.2 0.28 11.0 1.5 4.3 3 1 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system Fer4_6 PF12837.7 ADV19935.1 - 9.7e-06 25.4 2.1 9.7e-06 25.4 2.1 2.4 2 0 0 2 2 2 1 4Fe-4S binding domain AAA_15 PF13175.6 ADV19935.1 - 1.2e-05 25.2 0.0 0.11 12.1 0.0 3.0 4 0 0 4 4 3 2 AAA ATPase domain RsgA_GTPase PF03193.16 ADV19935.1 - 1.4e-05 25.1 0.0 0.086 12.7 0.0 2.7 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 ADV19935.1 - 2.5e-05 24.7 0.1 0.28 11.5 0.0 2.6 2 1 0 2 2 2 2 AAA ATPase domain NB-ARC PF00931.22 ADV19935.1 - 0.00011 21.6 0.0 0.11 11.6 0.0 2.2 2 0 0 2 2 2 2 NB-ARC domain Rad17 PF03215.15 ADV19935.1 - 0.00027 20.9 0.0 0.06 13.3 0.0 2.6 3 0 0 3 3 2 1 Rad17 P-loop domain Fer4_2 PF12797.7 ADV19935.1 - 0.00028 20.8 0.7 0.00028 20.8 0.7 2.4 2 0 0 2 2 2 1 4Fe-4S binding domain AAA_22 PF13401.6 ADV19935.1 - 0.00041 20.6 0.0 0.1 12.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 ADV19935.1 - 0.00094 18.9 0.2 1.6 8.5 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain NACHT PF05729.12 ADV19935.1 - 0.00099 19.1 1.4 0.082 12.8 0.0 2.5 2 0 0 2 2 2 1 NACHT domain Fer4_21 PF14697.6 ADV19935.1 - 0.0011 19.0 11.9 0.002 18.2 11.9 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain AAA PF00004.29 ADV19935.1 - 0.0015 19.0 0.1 2.3 8.6 0.0 2.9 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) Fer4_10 PF13237.6 ADV19935.1 - 0.0017 18.4 15.2 0.0021 18.2 1.5 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_7 PF12838.7 ADV19935.1 - 0.0031 18.1 1.5 0.0031 18.1 1.5 2.1 1 1 2 3 3 3 2 4Fe-4S dicluster domain RNA_helicase PF00910.22 ADV19935.1 - 0.0085 16.5 0.1 5.2 7.5 0.0 2.8 2 0 0 2 2 2 0 RNA helicase Fer4_9 PF13187.6 ADV19935.1 - 0.0094 16.1 12.3 0.018 15.2 12.3 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain TniB PF05621.11 ADV19935.1 - 0.016 14.6 0.2 0.64 9.4 0.0 3.1 4 0 0 4 4 4 0 Bacterial TniB protein AAA_7 PF12775.7 ADV19935.1 - 0.021 14.3 1.3 0.21 11.1 0.0 2.5 3 0 0 3 3 2 0 P-loop containing dynein motor region VirE PF05272.11 ADV19935.1 - 0.027 14.2 0.0 2.7 7.7 0.0 2.4 2 0 0 2 2 2 0 Virulence-associated protein E SbcCD_C PF13558.6 ADV19935.1 - 0.038 14.2 0.0 9.2 6.6 0.0 2.9 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit Fer4_17 PF13534.6 ADV19935.1 - 0.049 14.2 1.0 0.049 14.2 1.0 2.4 1 1 1 2 2 2 0 4Fe-4S dicluster domain TsaE PF02367.17 ADV19935.1 - 0.052 13.5 0.1 1.5 8.9 0.0 2.7 3 0 0 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Fer4_16 PF13484.6 ADV19935.1 - 0.053 14.5 1.7 0.053 14.5 1.7 2.5 1 1 1 2 2 2 0 4Fe-4S double cluster binding domain AAA_24 PF13479.6 ADV19935.1 - 0.056 13.2 0.8 8.2 6.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain SRP54 PF00448.22 ADV19935.1 - 0.066 12.8 2.8 1.7 8.2 0.1 2.3 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_33 PF13671.6 ADV19935.1 - 0.099 12.8 0.6 13 5.9 0.0 2.5 2 1 0 2 2 2 0 AAA domain Fer4_4 PF12800.7 ADV19935.1 - 0.17 12.4 14.8 0.14 12.7 3.0 2.4 2 0 0 2 2 2 0 4Fe-4S binding domain MeaB PF03308.16 ADV19935.1 - 0.18 10.8 0.1 1.4 7.9 0.0 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Roc PF08477.13 ADV19935.1 - 0.19 12.0 1.1 0.77 10.0 0.0 2.2 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_5 PF07728.14 ADV19935.1 - 0.32 11.0 2.2 3.3 7.7 0.1 2.6 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_23 PF13476.6 ADV19935.1 - 0.42 11.1 6.1 1.5 9.3 0.1 2.7 2 1 0 2 2 2 0 AAA domain Fer4_8 PF13183.6 ADV19935.1 - 4 8.0 10.9 0.25 11.8 1.5 2.3 1 1 1 2 2 2 0 4Fe-4S dicluster domain ZYG-11_interact PF05884.12 ADV19936.1 - 0.58 9.5 1.2 8 5.8 0.3 2.3 2 0 0 2 2 2 0 Interactor of ZYG-11 Arylsulfotran_2 PF14269.6 ADV19937.1 - 5.1e-51 173.8 2.0 3.3e-49 167.9 2.0 2.3 1 1 0 1 1 1 1 Arylsulfotransferase (ASST) Arylsulfotrans PF05935.11 ADV19937.1 - 5.8e-17 61.7 0.3 2.1e-16 59.8 0.3 1.8 1 1 0 1 1 1 1 Arylsulfotransferase (ASST) Gly_transf_sug PF04488.15 ADV19938.1 - 7.1e-10 39.4 0.1 1.6e-09 38.3 0.1 1.6 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif His_biosynth PF00977.21 ADV19939.1 - 1.5e-43 148.9 0.4 8.2e-42 143.2 0.4 3.1 1 1 0 1 1 1 1 Histidine biosynthesis protein GATase PF00117.28 ADV19939.1 - 1.3e-17 64.1 0.0 2e-17 63.6 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I GATase_3 PF07685.14 ADV19939.1 - 9.4e-08 31.9 0.0 1.6e-07 31.2 0.0 1.3 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain SNO PF01174.19 ADV19939.1 - 3.5e-06 27.0 0.0 2.7e-05 24.1 0.0 2.1 2 0 0 2 2 2 1 SNO glutamine amidotransferase family Peptidase_C26 PF07722.13 ADV19939.1 - 0.005 16.6 0.0 0.67 9.7 0.0 2.6 3 0 0 3 3 3 2 Peptidase C26 SNF5 PF04855.12 ADV19940.1 - 5.4e-57 193.3 0.2 5.4e-57 193.3 0.2 3.0 2 0 0 2 2 2 1 SNF5 / SMARCB1 / INI1 NT-C2 PF10358.9 ADV19941.1 - 1.4e-10 41.0 0.0 6.4e-05 22.7 0.0 3.2 3 0 0 3 3 3 3 N-terminal C2 in EEIG1 and EHBP1 proteins Sec5 PF15469.6 ADV19942.1 - 1.8e-49 168.2 0.0 3.9e-49 167.1 0.0 1.6 1 0 0 1 1 1 1 Exocyst complex component Sec5 Vps51 PF08700.11 ADV19942.1 - 0.052 13.6 0.6 0.3 11.2 0.0 2.6 3 0 0 3 3 3 0 Vps51/Vps67 KorB PF08535.10 ADV19942.1 - 0.071 13.2 0.2 23 5.1 0.0 2.9 2 0 0 2 2 2 0 KorB domain Bac_luciferase PF00296.20 ADV19942.1 - 0.079 12.4 0.1 0.14 11.6 0.1 1.3 1 0 0 1 1 1 0 Luciferase-like monooxygenase Rota_NS6 PF04866.12 ADV19942.1 - 0.097 12.9 0.0 0.36 11.1 0.0 2.0 1 0 0 1 1 1 0 Rotavirus non-structural protein 6 LXG PF04740.12 ADV19942.1 - 0.78 9.4 3.3 12 5.6 0.4 2.8 3 0 0 3 3 3 0 LXG domain of WXG superfamily Aldedh PF00171.22 ADV19943.1 - 8.8e-120 400.3 0.0 1.1e-119 400.0 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family bZIP_1 PF00170.21 ADV19945.1 - 0.0014 18.7 10.0 0.0061 16.6 5.8 2.2 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 ADV19945.1 - 0.0019 18.2 4.5 0.0019 18.2 4.5 2.2 2 0 0 2 2 2 1 Basic region leucine zipper UPF0242 PF06785.11 ADV19945.1 - 0.19 11.8 2.2 0.27 11.3 2.2 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DivIC PF04977.15 ADV19945.1 - 0.43 10.4 7.9 3.3 7.5 0.1 2.2 2 0 0 2 2 2 0 Septum formation initiator Atg14 PF10186.9 ADV19945.1 - 2.1 7.4 7.6 2.5 7.1 6.3 1.6 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF5320 PF17253.2 ADV19945.1 - 6.3 7.9 5.3 2.3 9.3 1.0 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5320) MFS_1 PF07690.16 ADV19946.1 - 7.3e-43 146.8 21.2 7.3e-43 146.8 21.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 ADV19946.1 - 0.00023 20.6 2.4 0.00056 19.3 2.4 1.6 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB Sugar_tr PF00083.24 ADV19946.1 - 0.00077 18.4 29.0 0.014 14.3 28.8 2.4 1 1 0 1 1 1 1 Sugar (and other) transporter Cation_efflux PF01545.21 ADV19947.1 - 3.5e-45 154.2 3.1 9.8e-45 152.7 3.1 1.7 1 1 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 ADV19947.1 - 8.7e-10 38.6 1.1 1.5e-09 37.8 1.1 1.4 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter MFS_1 PF07690.16 ADV19948.1 - 2.2e-25 89.4 35.6 2.2e-25 89.4 35.6 1.5 1 1 1 2 2 2 2 Major Facilitator Superfamily YrhC PF14143.6 ADV19948.1 - 0.17 12.0 5.8 5.4 7.2 0.1 3.4 3 0 0 3 3 3 0 YrhC-like protein Mit_ribos_Mrp51 PF11709.8 ADV19949.1 - 2.3e-05 24.1 2.8 5.9e-05 22.8 2.8 1.6 1 1 0 1 1 1 1 Mitochondrial ribosomal protein subunit Peptidase_M3_N PF08439.10 ADV19949.1 - 0.16 12.3 0.3 0.44 10.8 0.3 1.8 1 0 0 1 1 1 0 Oligopeptidase F HA2 PF04408.23 ADV19950.1 - 1.9e-17 63.5 0.2 8.2e-17 61.5 0.0 2.2 2 0 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.31 ADV19950.1 - 7.6e-13 48.8 0.0 2.1e-12 47.4 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 ADV19950.1 - 2.3e-09 37.5 0.0 4.8e-09 36.5 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 ADV19950.1 - 0.0033 17.2 0.0 0.017 14.9 0.0 2.2 1 1 0 1 1 1 1 DEAD/DEAH box helicase RNA_pol_Rpb5_N PF03871.14 ADV19950.1 - 0.029 14.9 0.0 3.6 8.2 0.0 2.5 2 0 0 2 2 2 0 RNA polymerase Rpb5, N-terminal domain AAA_22 PF13401.6 ADV19950.1 - 0.033 14.5 0.0 0.39 11.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 ADV19950.1 - 0.036 14.6 0.0 0.12 12.9 0.0 1.9 1 0 0 1 1 1 0 ABC transporter RsgA_GTPase PF03193.16 ADV19950.1 - 0.039 13.9 0.0 0.082 12.8 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase Viral_helicase1 PF01443.18 ADV19950.1 - 0.1 12.3 0.0 0.23 11.2 0.0 1.6 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase TP_methylase PF00590.20 ADV19950.1 - 0.14 12.1 0.0 0.33 10.8 0.0 1.8 1 1 0 1 1 1 0 Tetrapyrrole (Corrin/Porphyrin) Methylases NAM-associated PF14303.6 ADV19950.1 - 0.14 12.9 4.5 0.42 11.3 4.5 1.7 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain Ribosomal_L27 PF01016.19 ADV19951.1 - 5.7e-32 109.6 0.1 8.7e-32 109.0 0.1 1.2 1 0 0 1 1 1 1 Ribosomal L27 protein AAA PF00004.29 ADV19952.1 - 2.2e-92 306.4 0.0 1.4e-47 161.4 0.0 2.3 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ADV19952.1 - 6.3e-22 77.1 2.3 5.4e-10 38.9 1.6 2.8 2 1 0 2 2 2 2 AAA+ lid domain RuvB_N PF05496.12 ADV19952.1 - 1.8e-11 44.0 0.0 0.0002 21.1 0.0 2.6 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 ADV19952.1 - 1.9e-11 44.6 4.8 0.00094 19.6 0.0 4.7 3 2 0 4 4 3 2 AAA ATPase domain AAA_33 PF13671.6 ADV19952.1 - 2.2e-09 37.6 0.0 0.00081 19.6 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 ADV19952.1 - 7e-09 35.8 1.6 0.0042 17.1 0.0 3.9 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 ADV19952.1 - 1.7e-08 34.8 0.0 0.00045 20.4 0.0 2.5 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 ADV19952.1 - 3.6e-07 30.5 2.4 0.0064 16.8 0.0 4.5 3 2 1 4 4 3 1 AAA domain Viral_helicase1 PF01443.18 ADV19952.1 - 7.1e-06 25.9 0.0 0.021 14.6 0.0 2.2 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase AAA_3 PF07726.11 ADV19952.1 - 8.7e-06 25.6 0.0 0.016 15.1 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 ADV19952.1 - 1.1e-05 24.9 0.1 0.1 11.9 0.0 2.4 2 0 0 2 2 2 2 Zeta toxin AAA_14 PF13173.6 ADV19952.1 - 2.6e-05 24.2 0.0 0.025 14.6 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_28 PF13521.6 ADV19952.1 - 3.5e-05 24.1 0.0 0.21 11.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 ADV19952.1 - 3.5e-05 24.3 0.0 0.31 11.6 0.0 2.4 2 0 0 2 2 2 2 AAA domain TIP49 PF06068.13 ADV19952.1 - 8.8e-05 21.9 0.1 0.18 11.0 0.0 2.4 2 1 0 2 2 2 2 TIP49 P-loop domain IstB_IS21 PF01695.17 ADV19952.1 - 0.0001 22.1 0.3 0.018 14.8 0.0 2.9 2 1 1 3 3 3 1 IstB-like ATP binding protein TsaE PF02367.17 ADV19952.1 - 0.00012 22.1 0.0 0.49 10.4 0.0 2.3 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase PF06745.13 ADV19952.1 - 0.00012 21.5 0.1 1.5 8.1 0.0 3.2 3 0 0 3 3 3 2 KaiC RNA_helicase PF00910.22 ADV19952.1 - 0.00013 22.3 0.0 0.051 14.0 0.0 2.8 2 1 0 2 2 2 1 RNA helicase Cytidylate_kin2 PF13189.6 ADV19952.1 - 0.00023 21.3 0.0 0.13 12.4 0.0 2.3 2 0 0 2 2 2 1 Cytidylate kinase-like family ABC_tran PF00005.27 ADV19952.1 - 0.00034 21.1 0.0 0.45 11.0 0.0 2.7 2 0 0 2 2 2 1 ABC transporter Mg_chelatase PF01078.21 ADV19952.1 - 0.0004 19.8 1.7 0.062 12.7 0.0 2.9 2 1 1 3 3 3 1 Magnesium chelatase, subunit ChlI DUF815 PF05673.13 ADV19952.1 - 0.00046 19.4 0.0 0.067 12.3 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF815) NACHT PF05729.12 ADV19952.1 - 0.00081 19.3 1.8 1 9.3 0.0 3.5 2 1 1 3 3 3 1 NACHT domain Sigma54_activat PF00158.26 ADV19952.1 - 0.0015 18.3 0.1 0.35 10.6 0.0 3.1 2 1 0 2 2 2 1 Sigma-54 interaction domain Vps4_C PF09336.10 ADV19952.1 - 0.0026 17.7 0.1 2.2 8.3 0.0 2.7 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA_17 PF13207.6 ADV19952.1 - 0.003 18.0 0.3 5.2 7.5 0.0 3.1 2 1 0 2 2 2 0 AAA domain AAA_7 PF12775.7 ADV19952.1 - 0.004 16.7 0.1 1.5 8.3 0.0 2.9 3 1 0 3 3 2 1 P-loop containing dynein motor region ATPase_2 PF01637.18 ADV19952.1 - 0.0041 17.1 0.0 1.8 8.4 0.0 2.9 2 2 1 4 4 3 1 ATPase domain predominantly from Archaea AAA_25 PF13481.6 ADV19952.1 - 0.0069 16.0 3.6 2.6 7.6 0.1 4.1 3 1 0 4 4 4 1 AAA domain AAA_11 PF13086.6 ADV19952.1 - 0.013 15.3 0.5 1.6 8.5 0.0 2.5 3 0 0 3 3 2 0 AAA domain Rad17 PF03215.15 ADV19952.1 - 0.014 15.3 0.0 1.1 9.1 0.0 2.3 2 0 0 2 2 2 0 Rad17 P-loop domain CPT PF07931.12 ADV19952.1 - 0.014 15.2 0.0 0.3 10.9 0.0 2.3 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein AAA_24 PF13479.6 ADV19952.1 - 0.017 14.9 0.0 1.1 9.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain TniB PF05621.11 ADV19952.1 - 0.023 14.1 0.0 14 5.0 0.0 3.3 3 0 0 3 3 3 0 Bacterial TniB protein AAA_19 PF13245.6 ADV19952.1 - 0.058 13.7 0.8 15 5.9 0.2 2.7 2 1 0 2 2 2 0 AAA domain NB-ARC PF00931.22 ADV19952.1 - 0.07 12.3 0.1 0.98 8.5 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain SRPRB PF09439.10 ADV19952.1 - 0.18 11.2 0.0 23 4.4 0.0 2.3 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit WD40 PF00400.32 ADV19953.1 - 6.3e-23 80.6 10.5 1.7e-05 25.5 0.2 8.0 8 0 0 8 8 8 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV19953.1 - 7.3e-13 48.6 0.0 0.00012 22.3 0.1 4.4 4 1 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ADV19953.1 - 0.00037 20.4 0.0 0.081 12.8 0.1 3.1 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ADV19953.1 - 0.0021 17.9 5.7 6.5 6.8 0.0 5.1 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 ADV19953.1 - 0.22 10.4 0.0 18 4.1 0.0 3.0 4 0 0 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Proteasome_A_N PF10584.9 ADV19953.1 - 0.29 10.9 3.0 11 5.8 0.1 4.0 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature DEAD PF00270.29 ADV19955.1 - 1.6e-43 148.5 0.3 1.6e-43 148.5 0.3 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ADV19955.1 - 3.7e-32 111.0 0.3 3.9e-31 107.7 0.1 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain AAA_19 PF13245.6 ADV19955.1 - 0.00014 22.3 1.1 0.00089 19.6 0.8 2.3 2 1 0 2 2 2 1 AAA domain ResIII PF04851.15 ADV19955.1 - 0.00022 21.3 0.0 0.0004 20.4 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 ADV19955.1 - 0.00047 19.9 0.1 0.00072 19.3 0.1 1.4 1 0 0 1 1 1 1 AAA domain Flavi_DEAD PF07652.14 ADV19955.1 - 0.028 14.4 0.0 0.096 12.7 0.0 1.9 1 0 0 1 1 1 0 Flavivirus DEAD domain tRNA-synt_1b PF00579.25 ADV19955.1 - 0.029 13.7 0.1 0.11 11.7 0.0 1.9 2 0 0 2 2 2 0 tRNA synthetases class I (W and Y) UvrD-helicase PF00580.21 ADV19955.1 - 0.029 13.9 0.1 0.053 13.0 0.1 1.4 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain fragilysinNterm PF16376.5 ADV19955.1 - 0.083 12.6 0.4 0.27 11.0 0.0 2.0 3 0 0 3 3 3 0 N-terminal domain of fragilysin Phage_integrase PF00589.22 ADV19955.1 - 0.083 12.7 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Phage integrase family Helicase_RecD PF05127.14 ADV19955.1 - 0.1 12.4 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 Helicase Sec7_N PF12783.7 ADV19956.1 - 6.3e-44 149.7 0.7 1.3e-42 145.4 0.0 3.5 4 1 0 4 4 4 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DCB PF16213.5 ADV19956.1 - 5.6e-24 84.8 3.1 1.7e-23 83.2 3.1 1.9 1 0 0 1 1 1 1 Dimerisation and cyclophilin-binding domain of Mon2 Mon2_C PF16206.5 ADV19956.1 - 1.3e-23 83.1 0.9 3.3e-09 35.5 0.1 4.1 2 2 2 4 4 4 3 C-terminal region of Mon2 protein DUF1981 PF09324.10 ADV19956.1 - 2.4e-05 24.1 0.1 0.03 14.2 0.0 3.8 4 0 0 4 4 4 2 Domain of unknown function (DUF1981) DUF3775 PF12616.8 ADV19956.1 - 0.018 15.1 0.0 0.055 13.5 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3775) OST-HTH PF12872.7 ADV19956.1 - 0.13 12.1 0.0 0.41 10.5 0.0 1.8 1 0 0 1 1 1 0 OST-HTH/LOTUS domain PAP2 PF01569.21 ADV19957.1 - 2.9e-31 108.0 2.5 3.3e-31 107.9 1.4 1.6 2 0 0 2 2 2 1 PAP2 superfamily Cellulase PF00150.18 ADV19959.1 - 9.7e-29 100.7 6.0 3.4e-28 98.9 6.0 1.9 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Ricin_B_lectin PF00652.22 ADV19959.1 - 1.7e-11 44.4 7.6 1.7e-11 44.4 7.6 2.4 2 0 0 2 2 2 1 Ricin-type beta-trefoil lectin domain Calcipressin PF04847.12 ADV19960.1 - 8.4e-59 198.4 0.0 1e-58 198.2 0.0 1.1 1 0 0 1 1 1 1 Calcipressin RRM_1 PF00076.22 ADV19960.1 - 0.11 12.4 0.0 0.24 11.2 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Gtr1_RagA PF04670.12 ADV19961.1 - 1.4e-87 292.9 0.0 1.7e-87 292.6 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Roc PF08477.13 ADV19961.1 - 1.5e-08 34.9 0.0 3.3e-08 33.8 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ADV19961.1 - 2.5e-06 27.1 0.0 3.6e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ADV19961.1 - 5.4e-06 26.5 0.0 1e-05 25.6 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Ras PF00071.22 ADV19961.1 - 3e-05 23.7 0.1 0.00011 21.8 0.0 1.8 2 0 0 2 2 2 1 Ras family GTP_EFTU PF00009.27 ADV19961.1 - 0.0001 21.9 0.0 0.00018 21.1 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ADV19961.1 - 0.0037 17.2 0.3 1.9 8.4 0.1 2.4 2 0 0 2 2 2 2 RsgA GTPase ATP_bind_1 PF03029.17 ADV19961.1 - 0.0094 15.8 1.6 0.25 11.1 0.0 2.9 1 1 1 3 3 3 1 Conserved hypothetical ATP binding protein SRPRB PF09439.10 ADV19961.1 - 0.011 15.1 0.0 0.016 14.6 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit ABC_tran PF00005.27 ADV19961.1 - 0.065 13.7 0.1 0.11 12.9 0.1 1.6 1 1 0 1 1 1 0 ABC transporter AAA_7 PF12775.7 ADV19961.1 - 0.071 12.6 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region PduV-EutP PF10662.9 ADV19961.1 - 0.075 12.8 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Helicase_Sgs1 PF11408.8 ADV19961.1 - 0.097 12.7 1.3 10 6.2 0.3 2.5 2 0 0 2 2 2 0 Sgs1 RecQ helicase AAA_24 PF13479.6 ADV19961.1 - 0.14 11.9 0.1 2.1 8.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 ADV19961.1 - 0.17 11.7 0.1 0.63 9.8 0.1 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain G-alpha PF00503.20 ADV19961.1 - 0.46 9.6 2.2 4.3 6.4 0.2 2.7 1 1 1 3 3 3 0 G-protein alpha subunit IATP PF04568.12 ADV19962.1 - 8.4e-08 32.6 5.8 1.1e-07 32.2 5.8 1.3 1 1 0 1 1 1 1 Mitochondrial ATPase inhibitor, IATP Hjc PF01870.18 ADV19962.1 - 0.045 13.7 0.4 0.061 13.3 0.4 1.3 1 0 0 1 1 1 0 Archaeal holliday junction resolvase (hjc) zf-RING_2 PF13639.6 ADV19963.1 - 3.9e-09 36.7 4.9 6e-09 36.1 4.9 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 ADV19963.1 - 0.00013 21.7 3.6 0.00022 21.0 3.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ADV19963.1 - 0.00058 19.8 3.8 0.00092 19.1 3.8 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 ADV19963.1 - 0.00085 19.1 3.2 0.0013 18.5 3.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 ADV19963.1 - 0.002 17.7 3.3 0.0034 17.0 3.3 1.3 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-RING_11 PF17123.5 ADV19963.1 - 0.0031 17.2 0.9 0.007 16.1 0.9 1.6 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_UBOX PF13445.6 ADV19963.1 - 0.0067 16.4 3.9 0.014 15.4 3.9 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 ADV19963.1 - 0.015 15.2 2.3 0.026 14.4 2.3 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 ADV19963.1 - 0.072 13.2 1.1 0.12 12.4 1.1 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_1 PF14446.6 ADV19963.1 - 0.11 12.4 4.3 0.098 12.6 0.8 2.1 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 zf-rbx1 PF12678.7 ADV19963.1 - 0.27 11.5 6.1 0.66 10.3 6.1 1.7 1 1 0 1 1 1 0 RING-H2 zinc finger domain FANCL_C PF11793.8 ADV19963.1 - 0.32 11.2 2.0 0.59 10.4 2.0 1.4 1 0 0 1 1 1 0 FANCL C-terminal domain RINGv PF12906.7 ADV19963.1 - 0.94 9.7 3.5 1.8 8.7 3.5 1.5 1 0 0 1 1 1 0 RING-variant domain EssA PF10661.9 ADV19963.1 - 1.2 9.0 7.4 3.4 7.5 7.4 1.7 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein EssA DEAD PF00270.29 ADV19964.1 - 6.5e-47 159.5 0.0 1.1e-46 158.8 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ADV19964.1 - 2e-30 105.4 0.0 3.6e-30 104.6 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 ADV19964.1 - 0.12 12.4 0.0 0.5 10.3 0.0 2.0 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit CMS1 PF14617.6 ADV19964.1 - 0.13 11.6 0.0 0.22 10.8 0.0 1.3 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit MFS_1 PF07690.16 ADV19965.1 - 5.3e-13 48.6 53.2 3.2e-12 46.1 51.2 2.8 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 ADV19965.1 - 7.5e-08 31.3 21.7 1.2e-07 30.6 21.7 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 ADV19965.1 - 7.7e-05 21.7 13.1 7.7e-05 21.7 13.1 2.5 2 1 0 2 2 2 1 Sugar (and other) transporter FUN14 PF04930.15 ADV19965.1 - 1.6 9.2 9.0 0.21 12.0 3.0 2.4 2 0 0 2 2 2 0 FUN14 family PDT PF00800.18 ADV19967.1 - 5.5e-49 166.5 0.0 8.2e-49 165.9 0.0 1.2 1 0 0 1 1 1 1 Prephenate dehydratase WD40 PF00400.32 ADV19968.1 - 2.8e-25 88.1 9.5 0.00027 21.7 0.1 7.9 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV19968.1 - 2e-16 60.1 0.3 4.8e-06 26.8 0.2 4.8 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 ADV19968.1 - 2e-06 27.6 3.4 1.3e-05 25.0 0.1 2.5 1 1 2 3 3 3 2 PQQ-like domain Ge1_WD40 PF16529.5 ADV19968.1 - 0.00035 19.6 0.0 0.11 11.4 0.0 3.6 3 1 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ PF01011.21 ADV19968.1 - 0.29 11.2 1.3 13 5.9 0.0 3.8 4 0 0 4 4 4 0 PQQ enzyme repeat UQ_con PF00179.26 ADV19969.1 - 4e-48 162.6 0.0 4.6e-48 162.4 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 ADV19969.1 - 2.6e-05 23.9 0.0 3.3e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 ADV19969.1 - 0.1 12.9 0.0 0.13 12.6 0.0 1.3 1 0 0 1 1 1 0 RWD domain Mito_carr PF00153.27 ADV19970.1 - 4.4e-73 241.3 0.3 3.7e-26 90.9 0.0 4.0 4 0 0 4 4 4 4 Mitochondrial carrier protein Fungal_trans PF04082.18 ADV19971.1 - 3.3e-20 72.2 0.0 6.1e-20 71.4 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ADV19971.1 - 4.4e-08 33.1 4.2 8e-08 32.3 4.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CCDC106 PF15794.5 ADV19971.1 - 1.6 8.4 5.0 53 3.4 5.6 2.1 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 Epimerase PF01370.21 ADV19972.1 - 6.3e-13 48.8 0.0 8.1e-13 48.4 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ADV19972.1 - 2.2e-10 40.5 0.0 3.2e-10 39.9 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 ADV19972.1 - 4.7e-06 26.0 0.0 0.018 14.3 0.0 2.6 2 1 0 2 2 2 2 Male sterility protein 3Beta_HSD PF01073.19 ADV19972.1 - 1.4e-05 24.3 0.0 1.8e-05 23.9 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 ADV19972.1 - 0.013 14.6 0.0 0.02 14.0 0.0 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain PSDC PF12588.8 ADV19973.1 - 1.8e-51 173.8 0.0 2.7e-51 173.3 0.0 1.3 1 0 0 1 1 1 1 Phophatidylserine decarboxylase PS_Dcarbxylase PF02666.15 ADV19973.1 - 8.3e-41 139.7 0.0 1.4e-40 139.0 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase Biotin_lipoyl_2 PF13533.6 ADV19973.1 - 8.6e-05 22.3 0.5 0.014 15.2 0.2 2.4 2 0 0 2 2 2 2 Biotin-lipoyl like Peptidase_M23 PF01551.22 ADV19973.1 - 0.016 15.4 0.1 0.041 14.1 0.1 1.7 1 0 0 1 1 1 0 Peptidase family M23 RnfC_N PF13375.6 ADV19973.1 - 0.047 13.6 0.1 2.2 8.3 0.1 2.4 2 0 0 2 2 2 0 RnfC Barrel sandwich hybrid domain Cation_efflux PF01545.21 ADV19974.1 - 1.1e-05 25.2 5.9 1.9e-05 24.5 5.9 1.3 1 0 0 1 1 1 1 Cation efflux family DUF3500 PF12006.8 ADV19976.1 - 1.6e-91 306.9 0.0 1.8e-91 306.7 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3500) FAD_binding_3 PF01494.19 ADV19977.1 - 3.1e-15 56.3 0.2 1e-14 54.6 0.2 1.7 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 ADV19977.1 - 3.7e-05 23.9 0.3 9e-05 22.6 0.3 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 ADV19977.1 - 0.0015 18.1 2.2 0.0096 15.5 1.3 2.1 1 1 1 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ADV19977.1 - 0.01 15.1 0.1 0.022 14.0 0.1 1.5 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 ADV19977.1 - 0.021 13.9 0.5 0.057 12.5 0.5 1.7 1 0 0 1 1 1 0 FAD binding domain Trp_halogenase PF04820.14 ADV19977.1 - 0.049 12.5 0.7 0.081 11.8 0.7 1.3 1 0 0 1 1 1 0 Tryptophan halogenase GIDA PF01134.22 ADV19977.1 - 0.095 11.8 1.3 0.11 11.6 0.5 1.5 2 0 0 2 2 2 0 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 ADV19977.1 - 0.17 11.1 1.4 0.67 9.2 1.1 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase MFS_1 PF07690.16 ADV19978.1 - 1.1e-35 123.2 24.4 1.1e-35 123.2 24.4 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ADV19978.1 - 5.5e-14 51.9 9.0 5.5e-14 51.9 9.0 2.6 2 1 0 2 2 2 1 Sugar (and other) transporter BT1 PF03092.16 ADV19978.1 - 0.45 8.7 7.4 2.4 6.3 0.3 2.2 2 0 0 2 2 2 0 BT1 family SURF6 PF04935.12 ADV19979.1 - 7.4e-41 140.1 56.6 3.7e-40 137.9 50.7 2.2 2 0 0 2 2 2 2 Surfeit locus protein 6 RRP14 PF15459.6 ADV19979.1 - 2.2e-18 66.6 1.6 2.2e-18 66.6 1.6 4.7 3 1 0 3 3 3 1 60S ribosome biogenesis protein Rrp14 DUF2868 PF11067.8 ADV19979.1 - 1.5 8.3 5.1 2.6 7.5 5.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2868) RNase_PH PF01138.21 ADV19981.1 - 1.3e-27 96.9 0.0 2.1e-27 96.2 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 zf-RING_2 PF13639.6 ADV19982.1 - 3.3e-09 36.9 3.6 3.5e-08 33.7 1.1 2.4 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.7 ADV19982.1 - 1.9e-08 34.4 1.6 2.4e-08 34.1 0.1 1.9 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 ADV19982.1 - 2.9e-07 30.2 1.7 2.9e-07 30.2 1.7 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ADV19982.1 - 8.3e-06 25.7 0.7 4.5e-05 23.3 0.2 2.1 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 ADV19982.1 - 1.5e-05 24.7 1.8 2.3e-05 24.2 0.5 1.9 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 ADV19982.1 - 5.3e-05 23.0 2.0 6.3e-05 22.8 0.1 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ADV19982.1 - 0.00012 21.7 1.7 0.0035 17.0 0.2 2.5 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_3 PF13920.6 ADV19982.1 - 0.00021 21.1 1.9 0.0012 18.6 0.8 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 ADV19982.1 - 0.00061 19.4 0.8 0.0014 18.2 0.8 1.5 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-ANAPC11 PF12861.7 ADV19982.1 - 0.0031 17.5 0.5 0.0072 16.3 0.5 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 ADV19982.1 - 0.0074 16.3 7.1 0.016 15.2 1.9 2.8 2 1 1 3 3 3 1 RING-type zinc-finger zf-C3H2C3 PF17122.5 ADV19982.1 - 0.03 14.4 2.2 0.067 13.2 2.2 1.6 1 0 0 1 1 1 0 Zinc-finger zinc_ribbon_16 PF17034.5 ADV19982.1 - 0.12 12.5 0.5 0.26 11.5 0.5 1.4 1 0 0 1 1 1 0 Zinc-ribbon like family FANCL_C PF11793.8 ADV19982.1 - 0.38 11.0 2.1 1.9 8.7 0.7 2.4 2 0 0 2 2 2 0 FANCL C-terminal domain RINGv PF12906.7 ADV19982.1 - 2.3 8.4 6.3 0.34 11.1 2.0 1.8 2 0 0 2 2 2 0 RING-variant domain RTA1 PF04479.13 ADV19984.1 - 6.8e-05 22.6 0.2 6.8e-05 22.6 0.2 1.1 1 0 0 1 1 1 1 RTA1 like protein MFS_1 PF07690.16 ADV19985.1 - 1.7e-15 56.8 54.5 1.4e-11 44.0 29.9 3.1 2 1 1 3 3 3 3 Major Facilitator Superfamily ERG2_Sigma1R PF04622.12 ADV19986.1 - 2.6e-87 291.6 0.1 3.3e-87 291.2 0.1 1.1 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein Glyco_hydro_88 PF07470.13 ADV19987.1 - 3.3e-67 227.0 0.0 4.4e-67 226.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 DUF3659 PF12396.8 ADV19988.1 - 7.7e-108 352.4 67.5 8.9e-23 80.0 0.8 7.7 8 0 0 8 8 8 7 Protein of unknown function (DUF3659) HC2 PF07382.11 ADV19988.1 - 0.53 10.3 39.9 0.17 12.0 24.7 2.6 2 0 0 2 2 2 0 Histone H1-like nucleoprotein HC2 DUF3698 PF12479.8 ADV19989.1 - 0.21 12.1 0.1 0.44 11.1 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3698) DUF5321 PF17254.2 ADV19989.1 - 0.27 10.7 5.2 0.51 9.8 1.4 2.5 1 1 0 2 2 2 0 Family of unknown function (DUF5321) Nop14 PF04147.12 ADV19989.1 - 2.4 6.3 16.6 3.5 5.7 16.6 1.2 1 0 0 1 1 1 0 Nop14-like family NOA36 PF06524.12 ADV19989.1 - 5.3 6.3 7.0 9.4 5.4 7.0 1.4 1 0 0 1 1 1 0 NOA36 protein Zn_clus PF00172.18 ADV19990.1 - 3.3e-05 23.9 12.0 6.2e-05 23.0 12.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Anti-TRAP PF15777.5 ADV19990.1 - 1.6 8.7 5.5 29 4.7 5.5 2.5 2 0 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein FAA_hydrolase PF01557.18 ADV19991.1 - 1.1e-57 195.2 0.0 1.4e-57 194.9 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family YCII PF03795.14 ADV19992.1 - 7.2e-10 39.1 0.0 1.1e-09 38.5 0.0 1.3 1 0 0 1 1 1 1 YCII-related domain 2-Hacid_dh_C PF02826.19 ADV19993.1 - 1e-57 194.4 0.0 1.4e-57 193.9 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 ADV19993.1 - 7.6e-18 64.5 0.0 8.5e-18 64.3 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 ADV19993.1 - 3.8e-09 36.9 0.0 6.9e-09 36.1 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.12 ADV19993.1 - 0.016 14.8 0.0 0.025 14.1 0.0 1.3 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain F420_oxidored PF03807.17 ADV19993.1 - 0.053 14.1 0.0 0.11 13.1 0.0 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent AlaDh_PNT_C PF01262.21 ADV19993.1 - 0.055 12.8 0.0 0.15 11.4 0.0 1.5 1 1 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 ADV19994.1 - 4.7e-53 179.2 0.0 6.3e-53 178.8 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 ADV19994.1 - 2.8e-27 95.0 0.0 3.4e-27 94.7 0.0 1.0 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain AdoHcyase_NAD PF00670.21 ADV19994.1 - 0.025 14.7 0.0 0.058 13.5 0.0 1.6 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain NAD_binding_2 PF03446.15 ADV19994.1 - 0.039 14.1 0.0 0.075 13.2 0.0 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase UvrD_C_2 PF13538.6 ADV19994.1 - 0.045 13.6 0.0 0.086 12.7 0.0 1.4 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain DUF374 PF04028.13 ADV19994.1 - 0.11 12.0 1.0 0.22 11.1 0.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF374) Skp1 PF01466.19 ADV19995.1 - 8.3e-30 102.7 0.6 1.5e-29 101.9 0.6 1.4 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 ADV19995.1 - 2.8e-24 85.0 0.5 6.2e-24 83.9 0.1 1.7 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain BTB PF00651.31 ADV19995.1 - 0.00012 22.3 0.0 0.0034 17.6 0.0 2.1 2 0 0 2 2 2 1 BTB/POZ domain Myb_DNA-binding PF00249.31 ADV19995.1 - 0.093 12.9 0.5 23 5.3 0.3 2.7 2 0 0 2 2 2 0 Myb-like DNA-binding domain Fungal_trans PF04082.18 ADV19996.1 - 6.3e-20 71.3 0.0 1.4e-19 70.1 0.0 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ADV19996.1 - 3.8e-06 26.9 8.9 7.2e-06 26.0 8.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Dak1 PF02733.17 ADV19997.1 - 7.7e-101 337.1 0.0 1e-100 336.6 0.0 1.1 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.17 ADV19997.1 - 2.8e-42 144.6 1.8 4.9e-42 143.8 1.8 1.4 1 0 0 1 1 1 1 DAK2 domain Ribosomal_L34e PF01199.18 ADV19999.1 - 2.3e-43 146.4 2.7 2.8e-43 146.1 2.7 1.1 1 0 0 1 1 1 1 Ribosomal protein L34e ArfGap PF01412.18 ADV20000.1 - 5.1e-38 129.7 0.0 8.3e-38 129.1 0.0 1.3 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Atg8 PF02991.16 ADV20001.1 - 1.7e-50 169.5 0.2 2.1e-50 169.2 0.2 1.1 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 ADV20001.1 - 1.5e-06 28.5 0.0 1.9e-06 28.2 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 STAG PF08514.11 ADV20002.1 - 4.1e-33 113.7 0.3 4.1e-33 113.7 0.3 2.1 2 0 0 2 2 2 1 STAG domain HEAT_2 PF13646.6 ADV20002.1 - 1.8e-05 25.1 0.1 0.066 13.6 0.0 3.6 2 1 1 3 3 3 2 HEAT repeats HEAT PF02985.22 ADV20002.1 - 0.00038 20.5 1.0 22 5.7 0.0 5.9 6 0 0 6 6 6 2 HEAT repeat adh_short PF00106.25 ADV20003.1 - 1.9e-37 128.6 0.0 2.5e-37 128.2 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ADV20003.1 - 9.4e-29 100.6 0.0 1.2e-28 100.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.6 ADV20003.1 - 2.6e-05 24.2 0.0 3.9e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding ADH_zinc_N PF00107.26 ADV20003.1 - 0.04 13.9 0.2 0.086 12.8 0.2 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase KR PF08659.10 ADV20003.1 - 0.086 12.7 0.0 0.11 12.5 0.0 1.2 1 0 0 1 1 1 0 KR domain Glycos_transf_3 PF00591.21 ADV20004.1 - 2.9e-79 266.2 0.0 4.3e-79 265.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family, a/b domain Glycos_trans_3N PF02885.17 ADV20004.1 - 1.8e-10 40.5 0.0 4.1e-10 39.4 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferase family, helical bundle domain QueH PF02677.14 ADV20004.1 - 0.17 12.0 0.0 0.26 11.4 0.0 1.2 1 0 0 1 1 1 0 Epoxyqueuosine reductase QueH PNK3P PF08645.11 ADV20005.1 - 7.7e-52 175.2 0.0 9.6e-52 174.9 0.0 1.1 1 0 0 1 1 1 1 Polynucleotide kinase 3 phosphatase HAD PF12710.7 ADV20005.1 - 0.0069 16.8 0.1 0.41 11.0 0.1 2.5 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase EF-hand_6 PF13405.6 ADV20006.1 - 2.3e-11 42.7 0.2 0.00068 19.4 0.0 3.4 4 0 0 4 4 4 2 EF-hand domain EF-hand_1 PF00036.32 ADV20006.1 - 3e-10 38.9 0.0 0.0085 15.6 0.0 4.3 4 0 0 4 4 4 2 EF hand EF-hand_7 PF13499.6 ADV20006.1 - 3.1e-10 40.4 0.0 0.00011 22.6 0.0 2.5 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.6 ADV20006.1 - 9e-06 25.9 0.0 0.0042 17.4 0.0 2.4 2 1 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 ADV20006.1 - 7.8e-05 22.4 0.0 0.0043 16.9 0.0 3.1 3 1 1 4 4 4 1 EF-hand domain pair Big_3_2 PF12245.8 ADV20006.1 - 0.009 16.3 0.1 0.15 12.3 0.0 2.1 2 0 0 2 2 2 1 Bacterial Ig-like domain EF-hand_11 PF08976.11 ADV20006.1 - 0.061 14.2 0.0 0.14 13.1 0.0 1.6 2 0 0 2 2 2 0 EF-hand domain DDE_Tnp_IS66_C PF13817.6 ADV20006.1 - 0.19 12.0 0.2 0.51 10.6 0.1 1.7 2 0 0 2 2 2 0 IS66 C-terminal element DDHD PF02862.17 ADV20007.1 - 0.072 13.2 6.9 0.15 12.2 2.5 2.2 2 0 0 2 2 2 0 DDHD domain TFIIA PF03153.13 ADV20007.1 - 0.88 9.5 36.1 0.99 9.3 6.7 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit PP_M1 PF03012.14 ADV20007.1 - 8 5.9 10.7 16 4.9 10.7 1.4 1 0 0 1 1 1 0 Phosphoprotein Macoilin PF09726.9 ADV20007.1 - 8.1 4.9 8.6 14 4.0 8.6 1.3 1 0 0 1 1 1 0 Macoilin family V_ATPase_I PF01496.19 ADV20007.1 - 8.4 4.2 6.3 14 3.4 6.3 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Na_Ca_ex PF01699.24 ADV20008.1 - 1.1e-44 152.0 46.1 1.1e-27 96.8 17.9 2.6 3 0 0 3 3 3 2 Sodium/calcium exchanger protein MerT PF02411.15 ADV20008.1 - 2.6 8.1 12.1 2.4 8.2 0.9 3.6 3 0 0 3 3 3 0 MerT mercuric transport protein Isochorismatase PF00857.20 ADV20010.1 - 1.7e-23 83.7 0.0 2.3e-23 83.3 0.0 1.1 1 0 0 1 1 1 1 Isochorismatase family AMP-binding PF00501.28 ADV20011.1 - 2.7e-89 299.7 0.0 3.4e-89 299.4 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ADV20011.1 - 2e-23 83.2 1.3 6.4e-23 81.5 0.2 2.5 3 0 0 3 3 3 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 ADV20011.1 - 5.2e-12 45.5 3.9 1.5e-11 44.0 3.9 1.9 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus ABC_membrane PF00664.23 ADV20012.1 - 2e-110 368.8 20.1 8.4e-63 212.6 9.9 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 ADV20012.1 - 7.6e-67 224.0 0.0 1.6e-32 112.9 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 ADV20012.1 - 2.7e-13 49.9 2.4 0.00021 20.8 0.0 4.1 2 2 1 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 ADV20012.1 - 7.2e-07 29.5 0.4 0.014 15.6 0.1 3.7 3 1 0 3 3 3 2 AAA domain ABC_ATPase PF09818.9 ADV20012.1 - 8.9e-07 28.0 1.3 0.012 14.4 0.1 2.8 3 0 0 3 3 3 2 Predicted ATPase of the ABC class Zeta_toxin PF06414.12 ADV20012.1 - 1.2e-06 28.0 0.0 0.011 15.0 0.0 2.5 2 0 0 2 2 2 2 Zeta toxin AAA_29 PF13555.6 ADV20012.1 - 5.7e-06 26.0 1.3 0.035 13.9 0.5 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA PF00004.29 ADV20012.1 - 1.7e-05 25.2 0.8 0.13 12.6 0.2 4.1 2 2 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ADV20012.1 - 1.8e-05 25.2 6.0 0.016 15.6 0.1 3.6 2 2 0 2 2 2 2 AAA ATPase domain AAA_15 PF13175.6 ADV20012.1 - 5.4e-05 23.1 2.9 0.07 12.8 0.0 3.0 3 0 0 3 3 3 2 AAA ATPase domain RsgA_GTPase PF03193.16 ADV20012.1 - 5.7e-05 23.1 0.0 0.45 10.4 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_21 PF13304.6 ADV20012.1 - 5.7e-05 23.1 0.1 0.74 9.6 0.0 3.6 4 0 0 4 4 3 2 AAA domain, putative AbiEii toxin, Type IV TA system G-alpha PF00503.20 ADV20012.1 - 7e-05 22.1 0.0 0.17 11.0 0.0 2.3 2 0 0 2 2 2 2 G-protein alpha subunit AAA_5 PF07728.14 ADV20012.1 - 0.00019 21.4 0.2 1.5 8.8 0.0 4.0 5 0 0 5 5 3 2 AAA domain (dynein-related subfamily) AAA_23 PF13476.6 ADV20012.1 - 0.00023 21.8 0.0 1.7 9.1 0.0 3.1 3 0 0 3 3 3 2 AAA domain APS_kinase PF01583.20 ADV20012.1 - 0.0011 18.9 0.1 0.38 10.6 0.0 3.1 3 0 0 3 3 3 1 Adenylylsulphate kinase AAA_25 PF13481.6 ADV20012.1 - 0.0012 18.5 0.4 1.2 8.7 0.0 2.8 2 0 0 2 2 2 2 AAA domain SbcCD_C PF13558.6 ADV20012.1 - 0.0012 19.1 2.8 2 8.7 0.3 3.8 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_7 PF12775.7 ADV20012.1 - 0.0012 18.4 0.0 0.9 9.0 0.0 2.7 2 0 0 2 2 2 1 P-loop containing dynein motor region Rad17 PF03215.15 ADV20012.1 - 0.0015 18.5 0.0 0.019 14.9 0.0 2.3 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_30 PF13604.6 ADV20012.1 - 0.0015 18.3 4.1 0.74 9.5 0.1 4.0 3 1 0 3 3 2 1 AAA domain AAA_28 PF13521.6 ADV20012.1 - 0.0025 18.1 0.0 1.4 9.2 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 ADV20012.1 - 0.0031 18.1 0.0 3.8 8.1 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 ADV20012.1 - 0.0033 17.6 0.0 3.7 7.7 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 ADV20012.1 - 0.01 15.6 0.1 3.5 7.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.17 ADV20012.1 - 0.011 15.9 0.4 0.58 10.2 0.2 2.7 2 0 0 2 2 2 0 Helicase HerA, central domain RNA_helicase PF00910.22 ADV20012.1 - 0.016 15.6 0.0 3.3 8.1 0.0 3.2 3 0 0 3 3 3 0 RNA helicase PRK PF00485.18 ADV20012.1 - 0.016 14.9 0.0 6.3 6.5 0.0 2.7 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family Mg_chelatase PF01078.21 ADV20012.1 - 0.033 13.6 0.0 6.4 6.1 0.0 2.4 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI MMR_HSR1 PF01926.23 ADV20012.1 - 0.095 12.8 0.0 16 5.6 0.0 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase NB-ARC PF00931.22 ADV20012.1 - 0.13 11.4 0.1 7.8 5.6 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain ATP_bind_1 PF03029.17 ADV20012.1 - 0.14 11.9 0.1 14 5.4 0.0 3.1 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein AAA_17 PF13207.6 ADV20012.1 - 0.36 11.2 2.7 32 4.9 0.0 3.5 4 0 0 4 4 2 0 AAA domain Claudin_2 PF13903.6 ADV20012.1 - 1.2 8.8 0.0 1.2 8.8 0.0 3.6 4 0 0 4 4 4 0 PMP-22/EMP/MP20/Claudin tight junction cEGF PF12662.7 ADV20013.1 - 2 8.4 17.3 0.39 10.7 0.4 3.9 4 0 0 4 4 4 0 Complement Clr-like EGF-like ABC_membrane PF00664.23 ADV20015.1 - 2e-51 175.3 39.7 5.7e-30 104.9 10.6 4.0 4 1 0 4 4 4 3 ABC transporter transmembrane region ABC_tran PF00005.27 ADV20015.1 - 3e-47 160.6 0.0 4.6e-27 95.2 0.0 2.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 ADV20015.1 - 1.4e-08 34.5 1.5 0.00065 19.2 0.1 4.0 3 1 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 ADV20015.1 - 5.5e-05 23.6 0.2 0.61 10.5 0.0 2.8 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 ADV20015.1 - 0.00031 20.4 4.6 0.29 10.9 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 ADV20015.1 - 0.00092 19.5 1.0 1.4 9.2 0.1 3.5 3 0 0 3 3 3 1 AAA domain T2SSE PF00437.20 ADV20015.1 - 0.0031 16.6 2.5 0.038 13.1 0.2 2.4 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_23 PF13476.6 ADV20015.1 - 0.0033 18.0 0.2 0.0033 18.0 0.2 3.6 4 0 0 4 4 3 1 AAA domain AAA_25 PF13481.6 ADV20015.1 - 0.0086 15.7 0.3 5.5 6.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 ADV20015.1 - 0.023 14.7 0.7 6.9 6.7 0.0 3.4 4 0 0 4 4 4 0 AAA domain (dynein-related subfamily) AAA_21 PF13304.6 ADV20015.1 - 0.027 14.3 4.9 3.7 7.3 0.8 3.4 3 0 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system IstB_IS21 PF01695.17 ADV20015.1 - 0.11 12.2 0.5 25 4.5 0.0 3.1 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_33 PF13671.6 ADV20015.1 - 0.14 12.3 0.0 16 5.6 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 ADV20015.1 - 0.16 11.5 0.2 19 4.7 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region cobW PF02492.19 ADV20015.1 - 0.19 11.3 3.6 0.34 10.5 0.3 2.5 2 1 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain RsgA_GTPase PF03193.16 ADV20015.1 - 0.2 11.5 1.0 9.3 6.1 0.0 2.7 2 0 0 2 2 2 0 RsgA GTPase MMR_HSR1 PF01926.23 ADV20015.1 - 0.31 11.1 1.4 2.5 8.2 0.1 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase NACHT PF05729.12 ADV20015.1 - 0.6 10.0 3.2 2.8 7.8 0.1 2.6 2 0 0 2 2 2 0 NACHT domain AAA_30 PF13604.6 ADV20015.1 - 0.83 9.3 7.3 2.8 7.6 0.1 3.0 3 0 0 3 3 3 0 AAA domain HLH PF00010.26 ADV20017.1 - 1.8e-12 47.0 0.3 3.4e-12 46.1 0.3 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Pyr_redox_2 PF07992.14 ADV20019.1 - 4.8e-52 177.0 0.0 6.5e-52 176.6 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ADV20019.1 - 2.4e-11 44.0 0.3 7.5e-10 39.2 0.0 3.4 4 1 0 4 4 4 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ADV20019.1 - 0.0039 16.5 0.1 1.4 8.1 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase RNA_pol_I_TF PF04090.12 ADV20020.1 - 5.8e-11 42.2 0.0 8.7e-11 41.7 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase I specific initiation factor TPR_8 PF13181.6 ADV20020.1 - 0.76 10.1 2.9 16 6.0 0.1 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF2841 PF11001.8 ADV20021.1 - 6.7e-37 126.3 0.2 1.4e-36 125.2 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2841) Spt5_N PF11942.8 ADV20021.1 - 0.01 16.8 0.3 0.024 15.6 0.3 1.5 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal EIN3 PF04873.13 ADV20021.1 - 0.063 12.6 0.1 0.12 11.7 0.1 1.4 1 0 0 1 1 1 0 Ethylene insensitive 3 SelR PF01641.18 ADV20022.1 - 1.5e-51 173.6 0.1 1.7e-51 173.4 0.1 1.0 1 0 0 1 1 1 1 SelR domain Yippee-Mis18 PF03226.14 ADV20022.1 - 0.009 16.2 0.4 0.031 14.5 0.4 1.7 1 1 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DZR PF12773.7 ADV20022.1 - 0.068 13.2 1.6 5.5 7.1 0.0 2.3 2 1 1 3 3 3 0 Double zinc ribbon RIG-I_C-RD PF11648.8 ADV20022.1 - 0.14 12.4 0.0 0.87 9.8 0.0 1.9 2 0 0 2 2 2 0 C-terminal domain of RIG-I PCI PF01399.27 ADV20023.1 - 2.1e-09 37.8 0.0 9.4e-09 35.7 0.0 2.1 3 0 0 3 3 3 1 PCI domain Retrotran_gag_2 PF14223.6 ADV20023.1 - 0.061 13.0 0.0 0.2 11.3 0.0 1.8 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type Ion_trans_2 PF07885.16 ADV20024.1 - 1.6e-24 85.7 28.3 3.8e-14 52.4 8.4 3.2 3 0 0 3 3 3 2 Ion channel Bunya_NS-S_2 PF03231.13 ADV20024.1 - 0.0023 16.8 0.0 0.0047 15.8 0.0 1.4 1 0 0 1 1 1 1 Bunyavirus non-structural protein NS-S Sterol-sensing PF12349.8 ADV20024.1 - 0.84 9.5 4.5 24 4.8 0.3 3.7 3 0 0 3 3 3 0 Sterol-sensing domain of SREBP cleavage-activation Peptidase_M24 PF00557.24 ADV20025.1 - 1.2e-51 175.4 0.0 1.5e-51 175.1 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 zf-C6H2 PF15801.5 ADV20025.1 - 3.4e-19 68.9 9.2 1e-18 67.4 8.4 2.0 2 0 0 2 2 2 1 zf-MYND-like zinc finger, mRNA-binding zf-MYND PF01753.18 ADV20025.1 - 3.6e-05 23.8 5.5 7.5e-05 22.7 5.5 1.6 1 0 0 1 1 1 1 MYND finger Peptidase_S24 PF00717.23 ADV20026.1 - 6.8e-06 26.0 0.0 4.5e-05 23.3 0.0 2.2 2 1 0 2 2 2 1 Peptidase S24-like CN_hydrolase PF00795.22 ADV20027.1 - 2.5e-42 145.0 0.0 3.2e-42 144.7 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase ERCC4 PF02732.15 ADV20028.1 - 4e-25 88.8 0.2 6.6e-25 88.1 0.2 1.4 1 0 0 1 1 1 1 ERCC4 domain SKG6 PF08693.10 ADV20029.1 - 0.084 12.3 0.1 0.19 11.2 0.1 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain PQ-loop PF04193.14 ADV20030.1 - 1e-37 127.7 11.8 3.6e-19 68.3 1.8 2.5 2 0 0 2 2 2 2 PQ loop repeat MFS_1 PF07690.16 ADV20031.1 - 1.8e-49 168.6 35.0 7.2e-49 166.6 33.9 2.2 2 1 0 2 2 2 1 Major Facilitator Superfamily zf-RING_2 PF13639.6 ADV20032.1 - 9.4e-09 35.5 11.3 1.5e-08 34.8 11.3 1.4 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 ADV20032.1 - 1.4e-07 31.7 8.1 2.7e-07 30.8 8.1 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 ADV20032.1 - 3.7e-07 29.8 3.7 6.8e-07 28.9 3.7 1.4 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 ADV20032.1 - 6.8e-07 29.0 11.6 1.1e-06 28.3 11.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 ADV20032.1 - 7.6e-07 29.1 2.0 1.7e-06 27.9 2.0 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.6 ADV20032.1 - 6.4e-06 26.0 9.4 1e-05 25.4 9.4 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 ADV20032.1 - 2.2e-05 24.2 12.4 3.4e-05 23.6 12.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ADV20032.1 - 3e-05 23.8 7.3 4.8e-05 23.1 7.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ADV20032.1 - 5.2e-05 23.0 7.5 0.0001 22.1 7.5 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 ADV20032.1 - 0.0045 17.0 10.2 0.0095 15.9 10.2 1.6 1 0 0 1 1 1 1 RING-type zinc-finger Zn_ribbon_17 PF17120.5 ADV20032.1 - 0.041 13.5 8.6 0.069 12.8 8.6 1.3 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type Cwf_Cwc_15 PF04889.12 ADV20032.1 - 0.1 12.3 2.8 0.22 11.2 2.8 1.5 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein zf-Nse PF11789.8 ADV20032.1 - 0.41 10.5 2.6 0.92 9.4 2.6 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit PHD PF00628.29 ADV20032.1 - 0.46 10.4 9.9 0.76 9.7 9.9 1.4 1 0 0 1 1 1 0 PHD-finger RINGv PF12906.7 ADV20032.1 - 0.7 10.1 10.1 1.2 9.3 10.1 1.4 1 0 0 1 1 1 0 RING-variant domain Zf_RING PF16744.5 ADV20032.1 - 0.83 9.8 6.2 1.6 8.9 6.2 1.5 1 0 0 1 1 1 0 KIAA1045 RING finger zf-RING_9 PF13901.6 ADV20032.1 - 2.7 7.9 7.1 7.1 6.6 7.1 1.6 1 1 0 1 1 1 0 Putative zinc-RING and/or ribbon zf-RING_4 PF14570.6 ADV20032.1 - 6 6.8 8.6 11 5.9 8.6 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain FANCL_C PF11793.8 ADV20032.1 - 6 7.1 7.4 17 5.7 7.4 1.7 1 1 0 1 1 1 0 FANCL C-terminal domain Pkinase PF00069.25 ADV20033.1 - 3.1e-64 216.9 0.0 4.3e-64 216.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV20033.1 - 2e-42 145.3 0.0 3.2e-42 144.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ADV20033.1 - 1.7e-07 30.4 0.0 1.7e-07 30.4 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 ADV20033.1 - 1e-06 28.9 1.7 0.0074 16.2 0.0 3.3 2 1 1 3 3 3 2 Phosphotransferase enzyme family Kdo PF06293.14 ADV20033.1 - 0.0015 17.9 1.7 0.0069 15.8 0.0 2.2 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ADV20033.1 - 0.017 14.5 0.0 0.017 14.5 0.0 1.7 2 0 0 2 2 2 0 Kinase-like RIO1 PF01163.22 ADV20033.1 - 0.05 13.2 0.0 0.094 12.3 0.0 1.3 1 0 0 1 1 1 0 RIO1 family Asp PF00026.23 ADV20036.1 - 6.8e-114 380.5 0.1 8.1e-114 380.3 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 ADV20036.1 - 5.3e-15 56.1 0.6 3.7e-13 50.1 0.6 2.5 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal TAXi_C PF14541.6 ADV20036.1 - 2.6e-06 27.3 0.0 7.7e-05 22.5 0.0 2.3 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.6 ADV20036.1 - 0.00031 21.3 0.1 2 9.1 0.0 3.0 2 1 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.6 ADV20036.1 - 0.0019 18.8 0.0 3.2 8.4 0.0 2.6 2 0 0 2 2 2 2 gag-polyprotein putative aspartyl protease GTP_EFTU PF00009.27 ADV20037.1 - 3.5e-33 114.8 5.2 1e-32 113.3 1.2 2.6 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 ADV20037.1 - 1.8e-31 108.4 0.9 5.8e-31 106.7 0.9 1.9 1 0 0 1 1 1 1 Translation-initiation factor 2 MMR_HSR1 PF01926.23 ADV20037.1 - 2e-07 31.1 0.0 4.3e-07 30.0 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.6 ADV20037.1 - 0.0002 21.2 8.4 0.006 16.5 0.5 3.8 4 0 0 4 4 4 1 Elongation factor Tu domain 4 PduV-EutP PF10662.9 ADV20037.1 - 0.0008 19.2 0.2 0.33 10.7 0.1 2.3 2 0 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation Cwf_Cwc_15 PF04889.12 ADV20037.1 - 0.0065 16.2 3.8 0.018 14.8 3.8 1.7 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein MeaB PF03308.16 ADV20037.1 - 0.0086 15.1 0.4 0.03 13.3 0.2 2.0 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Arf PF00025.21 ADV20037.1 - 0.011 15.2 0.0 0.035 13.6 0.0 1.8 1 1 0 1 1 1 0 ADP-ribosylation factor family Roc PF08477.13 ADV20037.1 - 0.022 15.0 0.0 0.04 14.1 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.23 ADV20037.1 - 0.031 14.3 0.8 3.1 7.8 0.0 3.1 3 0 0 3 3 3 0 Dynamin family AAA_26 PF13500.6 ADV20037.1 - 0.041 13.7 0.5 0.1 12.4 0.1 1.8 2 0 0 2 2 2 0 AAA domain SRPRB PF09439.10 ADV20037.1 - 0.19 11.2 1.3 0.24 10.8 0.0 1.8 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit GTP_EFTU_D2 PF03144.25 ADV20037.1 - 0.35 11.3 8.4 0.38 11.2 0.7 3.5 4 0 0 4 4 4 0 Elongation factor Tu domain 2 Spt5-NGN PF03439.13 ADV20039.1 - 8.3e-19 67.3 0.0 1.6e-18 66.3 0.0 1.5 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section Spt5_N PF11942.8 ADV20039.1 - 3.7e-14 53.5 10.6 3.7e-14 53.5 10.6 3.4 2 1 0 2 2 2 1 Spt5 transcription elongation factor, acidic N-terminal CTD PF12815.7 ADV20039.1 - 1.1e-11 45.1 21.9 1.1e-11 45.1 21.9 3.9 3 1 1 4 4 4 2 Spt5 C-terminal nonapeptide repeat binding Spt4 KOW PF00467.29 ADV20039.1 - 2e-11 43.4 23.7 5.6e-05 22.9 3.1 4.9 4 0 0 4 4 4 3 KOW motif MreC PF04085.14 ADV20039.1 - 0.043 13.7 0.0 0.11 12.3 0.0 1.7 1 0 0 1 1 1 0 rod shape-determining protein MreC DGCR6 PF07324.11 ADV20040.1 - 9.1 5.9 9.2 19 4.8 9.2 1.4 1 0 0 1 1 1 0 DiGeorge syndrome critical region 6 (DGCR6) protein Torus PF16131.5 ADV20041.1 - 1.9e-07 31.7 0.1 1.9e-07 31.7 0.1 1.7 2 0 0 2 2 2 1 Torus domain zf_CCCH_4 PF18345.1 ADV20041.1 - 6.5e-06 26.0 4.3 7e-06 25.9 2.3 2.2 2 0 0 2 2 2 1 Zinc finger domain zf-CCCH PF00642.24 ADV20041.1 - 0.00046 20.0 2.4 0.00046 20.0 2.4 2.5 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.5 ADV20041.1 - 0.0037 17.4 0.4 0.012 15.8 0.1 2.0 2 0 0 2 2 2 1 Zinc-finger containing family RRM_1 PF00076.22 ADV20041.1 - 0.0056 16.5 0.1 0.012 15.4 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH_2 PF14608.6 ADV20041.1 - 0.0058 17.1 1.9 0.0058 17.1 1.9 2.2 2 0 0 2 2 2 1 RNA-binding, Nab2-type zinc finger zf-CCCH_4 PF18044.1 ADV20041.1 - 0.016 15.0 4.5 0.018 14.9 2.7 2.1 2 0 0 2 2 2 0 CCCH-type zinc finger FYVE PF01363.21 ADV20041.1 - 4.9 7.4 8.4 0.44 10.7 3.9 1.9 2 1 0 2 2 2 0 FYVE zinc finger NTP_transf_9 PF04248.12 ADV20042.1 - 1e-24 86.2 0.4 1.2e-24 86.0 0.4 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF427) G-patch_2 PF12656.7 ADV20043.1 - 1.8e-16 59.9 0.1 5.8e-16 58.3 0.1 2.0 1 0 0 1 1 1 1 G-patch domain CENP-B_dimeris PF09026.10 ADV20043.1 - 0.22 11.9 3.7 3.2 8.2 0.0 2.3 2 0 0 2 2 2 0 Centromere protein B dimerisation domain V-ATPase_H_N PF03224.14 ADV20044.1 - 2e-72 244.2 1.1 1.7e-71 241.1 0.3 2.4 2 1 0 2 2 2 1 V-ATPase subunit H V-ATPase_H_C PF11698.8 ADV20044.1 - 8e-42 142.0 0.0 2e-39 134.3 0.0 2.5 2 1 0 2 2 2 1 V-ATPase subunit H Adaptin_N PF01602.20 ADV20044.1 - 4.6e-05 22.2 0.2 0.091 11.3 0.0 2.3 2 0 0 2 2 2 2 Adaptin N terminal region HEAT_2 PF13646.6 ADV20044.1 - 0.00012 22.4 0.0 0.17 12.3 0.0 3.3 2 2 0 2 2 2 1 HEAT repeats KH_5 PF13184.6 ADV20044.1 - 0.00079 19.5 0.8 0.0022 18.0 0.0 2.1 2 0 0 2 2 2 1 NusA-like KH domain Arm PF00514.23 ADV20044.1 - 0.0014 18.6 0.6 8.6 6.6 0.1 4.4 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat HEAT PF02985.22 ADV20044.1 - 0.0015 18.6 3.2 0.099 12.9 0.0 4.6 5 1 0 5 5 5 1 HEAT repeat Arm_2 PF04826.13 ADV20044.1 - 0.0017 17.8 0.0 0.0039 16.7 0.0 1.5 1 0 0 1 1 1 1 Armadillo-like DUF4042 PF13251.6 ADV20044.1 - 0.016 14.9 0.1 0.4 10.4 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4042) Ribosomal_L27e PF01777.18 ADV20045.1 - 5.1e-36 122.9 5.5 7e-36 122.5 5.5 1.2 1 0 0 1 1 1 1 Ribosomal L27e protein family KOW PF00467.29 ADV20045.1 - 0.002 18.0 1.5 0.0046 16.9 1.5 1.7 1 0 0 1 1 1 1 KOW motif LSM PF01423.22 ADV20047.1 - 4.7e-16 58.2 0.0 5.7e-16 58.0 0.0 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 ADV20047.1 - 0.001 19.1 0.0 0.0013 18.8 0.0 1.1 1 0 0 1 1 1 1 Ataxin 2 SM domain Pkinase PF00069.25 ADV20048.1 - 1.5e-43 149.1 0.0 6.4e-42 143.7 0.0 3.3 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV20048.1 - 3.9e-34 118.1 0.0 6.1e-19 68.3 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 ADV20048.1 - 0.0043 17.0 0.0 0.0083 16.1 0.0 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ADV20048.1 - 0.0057 15.5 0.0 0.012 14.4 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase RIO1 PF01163.22 ADV20048.1 - 0.045 13.3 0.0 0.087 12.4 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Kinase-like PF14531.6 ADV20048.1 - 0.059 12.7 0.0 5.8 6.1 0.0 2.2 2 0 0 2 2 2 0 Kinase-like Kdo PF06293.14 ADV20048.1 - 0.095 12.0 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family HNH_2 PF13391.6 ADV20049.1 - 1.8e-06 27.9 0.0 3.6e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 HNH endonuclease CorA PF01544.18 ADV20050.1 - 1.4e-27 96.7 0.0 1.1e-12 47.8 0.0 3.2 3 0 0 3 3 3 3 CorA-like Mg2+ transporter protein DUF3402 PF11882.8 ADV20051.1 - 1.6e-136 456.1 0.0 3.9e-69 234.0 0.2 2.1 1 1 1 2 2 2 2 Domain of unknown function (DUF3402) N1221 PF07923.13 ADV20051.1 - 7.5e-52 176.3 0.0 1.2e-51 175.6 0.0 1.2 1 0 0 1 1 1 1 N1221-like protein Band_7 PF01145.25 ADV20052.1 - 1.1e-22 80.9 1.5 1.7e-22 80.3 1.5 1.3 1 0 0 1 1 1 1 SPFH domain / Band 7 family COMPASS-Shg1 PF05205.12 ADV20052.1 - 0.8 10.4 4.1 2.8 8.7 0.9 2.4 1 1 1 2 2 2 0 COMPASS (Complex proteins associated with Set1p) component shg1 LSM PF01423.22 ADV20054.1 - 2.3e-19 68.9 0.1 2.8e-19 68.6 0.1 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 ADV20054.1 - 0.014 15.5 0.0 0.019 15.1 0.0 1.2 1 0 0 1 1 1 0 Ataxin 2 SM domain Zn_clus PF00172.18 ADV20055.1 - 3.3e-11 43.1 11.1 5.1e-11 42.5 11.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PSI_integrin PF17205.3 ADV20055.1 - 0.015 15.0 0.5 0.036 13.8 0.5 1.6 1 0 0 1 1 1 0 Integrin plexin domain Gly_kinase PF02595.15 ADV20055.1 - 0.025 13.6 0.9 0.049 12.6 0.9 1.4 1 0 0 1 1 1 0 Glycerate kinase family Fungal_trans PF04082.18 ADV20055.1 - 0.034 13.2 0.0 0.058 12.4 0.0 1.4 1 0 0 1 1 1 0 Fungal specific transcription factor domain Ribosomal_S13_N PF08069.12 ADV20055.1 - 0.12 12.4 0.0 0.29 11.2 0.0 1.6 1 0 0 1 1 1 0 Ribosomal S13/S15 N-terminal domain Hid1 PF12722.7 ADV20056.1 - 2.7e-126 422.8 0.0 3.4e-97 326.5 0.0 2.7 1 1 1 2 2 2 2 High-temperature-induced dauer-formation protein Dymeclin PF09742.9 ADV20056.1 - 5.3e-71 239.9 0.0 6.6e-71 239.6 0.0 1.0 1 0 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein Stm1_N PF09598.10 ADV20056.1 - 3.5 8.6 7.3 0.36 11.7 1.5 2.5 2 0 0 2 2 2 0 Stm1 Cyclin_N PF00134.23 ADV20057.1 - 0.059 13.1 0.0 0.13 12.0 0.0 1.6 1 0 0 1 1 1 0 Cyclin, N-terminal domain Fungal_trans_2 PF11951.8 ADV20058.1 - 7.6e-58 196.2 3.0 7.6e-58 196.2 3.0 1.4 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ADV20058.1 - 1.5e-05 25.0 8.4 2.7e-05 24.2 8.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain 2-Hacid_dh_C PF02826.19 ADV20059.1 - 1.6e-45 154.6 0.0 2.5e-45 154.0 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 ADV20059.1 - 3.2e-16 59.2 0.0 3.3e-16 59.1 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain SGL PF08450.12 ADV20059.1 - 7.9e-08 32.2 0.0 1.8e-07 31.0 0.0 1.6 2 0 0 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region NHL PF01436.21 ADV20059.1 - 0.0069 16.4 0.0 0.27 11.3 0.0 2.8 2 0 0 2 2 2 1 NHL repeat PQQ_2 PF13360.6 ADV20059.1 - 0.0084 15.7 0.0 0.02 14.4 0.0 1.6 1 0 0 1 1 1 1 PQQ-like domain HpcH_HpaI PF03328.14 ADV20060.1 - 7.9e-35 120.0 0.0 9.3e-35 119.8 0.0 1.1 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family PEP-utilizers_C PF02896.18 ADV20060.1 - 0.0012 18.0 0.0 0.19 10.8 0.0 2.3 2 0 0 2 2 2 2 PEP-utilising enzyme, TIM barrel domain Ribosomal_L6 PF00347.23 ADV20061.1 - 4.7e-24 84.9 4.0 7.3e-13 49.0 2.9 2.2 2 0 0 2 2 2 2 Ribosomal protein L6 tRNA_int_end_N2 PF12928.7 ADV20061.1 - 0.25 11.6 0.9 1.1 9.5 0.1 2.2 2 1 1 3 3 3 0 tRNA-splicing endonuclease subunit sen54 N-term GATA PF00320.27 ADV20063.1 - 0.014 14.9 0.1 0.029 14.0 0.1 1.5 1 0 0 1 1 1 0 GATA zinc finger zf-C2H2 PF00096.26 ADV20066.1 - 4.6e-11 42.5 7.2 7.5e-05 23.0 0.2 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ADV20066.1 - 3.9e-06 27.0 8.4 0.0086 16.5 0.2 3.9 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 ADV20066.1 - 0.021 15.6 6.4 0.043 14.7 1.5 3.8 4 0 0 4 4 4 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 ADV20066.1 - 0.027 14.7 1.1 0.027 14.7 1.1 1.7 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2HC_2 PF13913.6 ADV20066.1 - 0.038 13.9 2.1 2.8 7.9 0.0 2.8 3 0 0 3 3 3 0 zinc-finger of a C2HC-type Zn_ribbon_SprT PF17283.2 ADV20066.1 - 0.56 10.2 6.0 1.7 8.6 2.2 2.5 2 0 0 2 2 2 0 SprT-like zinc ribbon domain zf-C2H2_6 PF13912.6 ADV20066.1 - 2.6 8.2 6.6 0.55 10.3 1.4 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_11 PF16622.5 ADV20066.1 - 3.6 7.4 6.8 0.6 9.9 0.3 2.7 3 0 0 3 3 3 0 zinc-finger C2H2-type p450 PF00067.22 ADV20067.1 - 1.9e-72 244.5 0.0 2.3e-72 244.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 GTP_EFTU PF00009.27 ADV20068.1 - 3.2e-52 176.9 0.0 5.3e-52 176.2 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 ADV20068.1 - 2.6e-16 59.4 0.2 8.6e-16 57.7 0.0 1.9 2 0 0 2 2 2 1 Elongation factor G C-terminus EFG_II PF14492.6 ADV20068.1 - 9.9e-07 28.8 0.0 2.2e-06 27.7 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_IV PF03764.18 ADV20068.1 - 0.0012 18.6 0.0 0.0056 16.4 0.0 2.1 2 0 0 2 2 2 1 Elongation factor G, domain IV GTP_EFTU_D2 PF03144.25 ADV20068.1 - 0.011 16.1 0.0 0.03 14.7 0.0 1.8 1 0 0 1 1 1 0 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 ADV20068.1 - 0.02 15.0 0.0 0.046 13.8 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase MitMem_reg PF13012.6 ADV20069.1 - 1.8e-30 105.6 0.1 2.9e-30 105.0 0.1 1.3 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.21 ADV20069.1 - 1e-24 86.8 0.0 3e-24 85.3 0.0 1.9 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Baculo_PEP_C PF04513.12 ADV20069.1 - 0.046 13.8 0.0 0.12 12.4 0.0 1.7 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus tRNA_bind_2 PF13725.6 ADV20069.1 - 0.21 11.3 5.6 0.33 10.6 5.6 1.3 1 0 0 1 1 1 0 Possible tRNA binding domain PhyH PF05721.13 ADV20070.1 - 1e-08 35.7 0.0 2.3e-08 34.5 0.0 1.6 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DUF1479 PF07350.12 ADV20070.1 - 0.00058 18.7 0.0 0.31 9.7 0.0 2.7 3 0 0 3 3 3 2 Protein of unknown function (DUF1479) DUF2304 PF10066.9 ADV20071.1 - 0.0032 17.7 1.8 0.0037 17.5 1.8 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2304) DUF5405 PF17399.2 ADV20071.1 - 0.096 13.0 0.3 0.14 12.4 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5405) Fusion_F0 PF13044.6 ADV20071.1 - 0.13 10.8 1.8 0.13 10.9 1.8 1.1 1 0 0 1 1 1 0 Fusion glycoprotein F0, Isavirus DUF4199 PF13858.6 ADV20072.1 - 0.033 14.6 0.0 0.047 14.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) bZIP_1 PF00170.21 ADV20073.1 - 0.00094 19.2 8.8 0.00094 19.2 8.8 1.9 2 0 0 2 2 2 1 bZIP transcription factor DUF4551 PF15087.6 ADV20073.1 - 5.8 5.6 7.1 7.9 5.2 7.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) DUF974 PF06159.13 ADV20074.1 - 6e-34 117.9 0.0 8.3e-34 117.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF974) Citrate_synt PF00285.21 ADV20076.1 - 1.1e-99 333.9 0.0 1.4e-99 333.6 0.0 1.1 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain PTP_tm PF18861.1 ADV20078.1 - 0.09 12.8 0.3 0.14 12.1 0.3 1.3 1 0 0 1 1 1 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J Histone PF00125.24 ADV20079.1 - 3.2e-46 157.0 0.0 4e-46 156.6 0.0 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 ADV20079.1 - 3.2e-05 24.0 0.0 4.5e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 ADV20079.1 - 0.0014 18.9 0.1 0.0021 18.4 0.1 1.3 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 ADV20079.1 - 0.009 16.3 0.8 0.019 15.2 0.8 1.6 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 ADV20079.1 - 0.053 13.6 0.0 0.068 13.2 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Ran_BP1 PF00638.18 ADV20080.1 - 1.9e-51 173.5 0.1 3.1e-51 172.7 0.1 1.3 1 0 0 1 1 1 1 RanBP1 domain WH1 PF00568.23 ADV20080.1 - 0.0012 18.8 0.0 0.0049 16.8 0.0 1.8 1 1 0 1 1 1 1 WH1 domain SecE PF00584.20 ADV20081.1 - 6.2e-11 42.1 0.0 8.2e-11 41.7 0.0 1.2 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex zf-C2H2 PF00096.26 ADV20082.1 - 3.7e-10 39.7 8.5 0.00029 21.1 0.2 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ADV20082.1 - 1.7e-08 34.6 7.2 0.00052 20.6 0.2 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ADV20082.1 - 2.7e-07 30.7 8.9 2.6e-05 24.4 1.1 3.1 3 0 0 3 3 2 2 Zinc-finger double domain zf-C2H2_6 PF13912.6 ADV20082.1 - 2.6e-05 24.1 5.5 0.061 13.3 0.9 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_11 PF16622.5 ADV20082.1 - 0.021 14.6 2.2 0.61 9.9 0.1 2.7 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-CHY PF05495.12 ADV20082.1 - 0.18 12.3 1.0 0.33 11.5 1.0 1.4 1 0 0 1 1 1 0 CHY zinc finger zf-met PF12874.7 ADV20082.1 - 0.26 11.8 2.2 28 5.3 0.0 2.5 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf_UBZ PF18439.1 ADV20082.1 - 0.46 10.1 2.0 5.8 6.6 0.1 2.3 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-AN1 PF01428.16 ADV20082.1 - 2.3 8.5 7.5 14 5.9 1.5 2.3 1 1 1 2 2 2 0 AN1-like Zinc finger zf-C2HE PF16278.5 ADV20082.1 - 2.7 8.5 6.7 6.7 7.2 1.2 2.3 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-MYST PF17772.1 ADV20082.1 - 3.1 7.5 6.1 2.8 7.6 0.1 3.4 3 0 0 3 3 3 0 MYST family zinc finger domain zf-C2HC_2 PF13913.6 ADV20082.1 - 5.3 7.1 8.5 0.17 11.8 1.9 2.0 2 0 0 2 2 2 0 zinc-finger of a C2HC-type Thioredoxin PF00085.20 ADV20085.1 - 2.2e-48 162.5 0.0 1.9e-26 92.1 0.1 2.3 2 0 0 2 2 2 2 Thioredoxin ERp29 PF07749.12 ADV20085.1 - 1.1e-28 100.0 0.6 2.9e-28 98.6 0.6 1.8 1 0 0 1 1 1 1 Endoplasmic reticulum protein ERp29, C-terminal domain OST3_OST6 PF04756.13 ADV20085.1 - 9.5e-18 64.6 0.0 7.4e-10 38.7 0.0 2.7 1 1 1 2 2 2 2 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 ADV20085.1 - 1.3e-11 44.9 0.6 4.6e-08 33.5 0.0 2.8 3 1 0 3 3 2 2 Thioredoxin-like domain ERp29_N PF07912.13 ADV20085.1 - 1.8e-06 28.1 0.0 0.022 14.9 0.0 2.9 2 1 0 2 2 2 2 ERp29, N-terminal domain Thioredoxin_6 PF13848.6 ADV20085.1 - 2e-06 27.8 0.0 0.00041 20.3 0.0 2.8 1 1 2 3 3 3 2 Thioredoxin-like domain AhpC-TSA PF00578.21 ADV20085.1 - 5.2e-06 26.4 0.0 0.00089 19.2 0.0 2.4 2 0 0 2 2 2 1 AhpC/TSA family Thioredoxin_7 PF13899.6 ADV20085.1 - 2.8e-05 24.2 0.0 0.0003 20.9 0.0 2.3 2 0 0 2 2 2 1 Thioredoxin-like Thioredoxin_9 PF14595.6 ADV20085.1 - 4.9e-05 23.1 0.0 0.032 14.0 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin Redoxin PF08534.10 ADV20085.1 - 0.00087 19.0 0.1 0.0033 17.1 0.0 1.9 2 0 0 2 2 2 1 Redoxin Thioredoxin_8 PF13905.6 ADV20085.1 - 0.0015 18.8 0.0 0.23 11.8 0.0 3.3 2 2 2 4 4 4 1 Thioredoxin-like HyaE PF07449.11 ADV20085.1 - 0.0045 16.9 0.0 0.95 9.5 0.0 2.6 2 0 0 2 2 2 1 Hydrogenase-1 expression protein HyaE TraF PF13728.6 ADV20085.1 - 0.0055 16.6 0.1 0.14 11.9 0.0 2.5 3 0 0 3 3 3 1 F plasmid transfer operon protein Glutaredoxin PF00462.24 ADV20085.1 - 0.0063 16.7 0.4 0.07 13.4 0.0 2.7 2 1 0 2 2 2 1 Glutaredoxin YscO PF07321.12 ADV20085.1 - 0.36 10.8 3.5 0.63 10.0 3.5 1.4 1 0 0 1 1 1 0 Type III secretion protein YscO YtxH PF12732.7 ADV20085.1 - 2.5 8.7 5.9 0.71 10.4 0.7 2.4 1 1 1 2 2 2 0 YtxH-like protein Choline_transpo PF04515.12 ADV20086.1 - 2.4e-68 230.7 16.1 2.4e-68 230.7 16.1 2.2 2 0 0 2 2 2 2 Plasma-membrane choline transporter Arch_flagellin PF01917.16 ADV20086.1 - 6.1 7.0 6.2 2.9 8.1 3.2 1.9 2 0 0 2 2 2 0 Archaebacterial flagellin NUDIX_4 PF14815.6 ADV20087.1 - 6.6e-14 51.8 0.0 1.3e-13 50.9 0.0 1.5 1 0 0 1 1 1 1 NUDIX domain HhH-GPD PF00730.25 ADV20087.1 - 3.1e-06 27.6 0.0 6.1e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 ADV20087.1 - 0.093 12.6 0.0 0.23 11.4 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix motif EndIII_4Fe-2S PF10576.9 ADV20087.1 - 0.12 12.8 6.3 0.23 11.9 6.3 1.5 1 0 0 1 1 1 0 Iron-sulfur binding domain of endonuclease III Sulfate_transp PF00916.20 ADV20088.1 - 1.1e-108 363.4 13.2 1.4e-108 363.1 13.2 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 ADV20088.1 - 5.9e-10 38.8 0.0 1.2e-09 37.8 0.0 1.4 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 ADV20088.1 - 0.01 16.2 12.3 0.091 13.2 2.7 2.7 2 1 0 2 2 2 0 Molybdate transporter of MFS superfamily Sulfate_transp PF00916.20 ADV20089.1 - 6.7e-63 212.7 21.8 6.7e-63 212.7 21.8 1.4 2 0 0 2 2 2 1 Sulfate permease family cNMP_binding PF00027.29 ADV20089.1 - 4.9e-15 55.4 0.0 8.7e-15 54.6 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain STAS PF01740.21 ADV20089.1 - 7.3e-09 35.3 0.0 2.4e-08 33.6 0.0 1.9 1 0 0 1 1 1 1 STAS domain DUF5389 PF17364.2 ADV20089.1 - 0.058 13.4 0.6 0.22 11.6 0.3 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5389) HPHLAWLY PF14925.6 ADV20089.1 - 0.071 11.8 0.4 0.11 11.2 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function PRCC PF10253.9 ADV20090.1 - 0.00093 20.0 4.1 0.0013 19.6 4.1 1.1 1 0 0 1 1 1 1 Mitotic checkpoint regulator, MAD2B-interacting ParA PF10609.9 ADV20091.1 - 7.2e-80 268.0 0.1 8.9e-80 267.7 0.1 1.1 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 ADV20091.1 - 1.8e-07 31.3 0.0 2.9e-07 30.6 0.0 1.5 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 ADV20091.1 - 1.6e-06 28.2 0.1 0.0002 21.3 0.0 2.2 2 0 0 2 2 2 1 AAA domain MipZ PF09140.11 ADV20091.1 - 6.6e-05 22.3 0.0 0.00058 19.2 0.0 2.0 2 0 0 2 2 2 1 ATPase MipZ ArsA_ATPase PF02374.15 ADV20091.1 - 9.2e-05 21.8 0.2 0.0018 17.5 0.1 2.4 2 1 0 2 2 2 1 Anion-transporting ATPase FtsK_SpoIIIE PF01580.18 ADV20091.1 - 0.024 14.0 0.1 0.036 13.4 0.1 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_25 PF13481.6 ADV20091.1 - 0.031 13.8 0.0 0.047 13.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain tRNA-synt_1c PF00749.21 ADV20092.1 - 7.8e-109 363.4 0.0 1.2e-108 362.7 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 ADV20092.1 - 1.7e-37 129.0 0.0 8.2e-37 126.7 0.0 2.2 3 0 0 3 3 3 1 tRNA synthetases class I (E and Q), anti-codon binding domain tRNA_synt_1c_R1 PF04558.15 ADV20092.1 - 4.6e-33 114.5 0.0 7.5e-33 113.8 0.0 1.3 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 tRNA_synt_1c_R2 PF04557.15 ADV20092.1 - 3.1e-06 28.0 0.2 3.1e-06 28.0 0.2 2.5 2 0 0 2 2 2 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 TRM PF02005.16 ADV20093.1 - 4.9e-119 397.9 1.2 7.7e-90 301.8 0.0 2.0 1 1 0 2 2 2 2 N2,N2-dimethylguanosine tRNA methyltransferase CpXC PF14353.6 ADV20093.1 - 0.045 13.8 0.0 0.82 9.7 0.0 2.5 2 0 0 2 2 2 0 CpXC protein Met_10 PF02475.16 ADV20093.1 - 0.055 13.2 0.0 0.14 11.9 0.0 1.7 1 0 0 1 1 1 0 Met-10+ like-protein LsmAD PF06741.13 ADV20093.1 - 5.3 7.7 8.5 6.1 7.5 3.5 3.2 3 0 0 3 3 3 0 LsmAD domain ASF1_hist_chap PF04729.13 ADV20094.1 - 6.3e-62 208.1 0.1 7.9e-62 207.8 0.1 1.1 1 0 0 1 1 1 1 ASF1 like histone chaperone DUF4201 PF13870.6 ADV20095.1 - 0.005 16.6 7.9 0.005 16.6 7.9 6.1 2 1 3 5 5 5 2 Domain of unknown function (DUF4201) GAS PF13851.6 ADV20095.1 - 0.013 14.8 73.2 0.22 10.9 9.5 5.6 1 1 3 5 5 5 0 Growth-arrest specific micro-tubule binding Med9 PF07544.13 ADV20095.1 - 0.024 14.7 1.2 0.024 14.7 1.2 5.2 4 3 2 6 6 6 0 RNA polymerase II transcription mediator complex subunit 9 HrpB7 PF09486.10 ADV20095.1 - 0.024 15.0 1.1 0.024 15.0 1.1 5.6 2 2 1 4 4 4 0 Bacterial type III secretion protein (HrpB7) Chromo PF00385.24 ADV20095.1 - 0.83 9.6 5.9 0.23 11.4 0.7 2.8 3 0 0 3 3 3 0 Chromo (CHRromatin Organisation MOdifier) domain Spc7 PF08317.11 ADV20095.1 - 1.5 7.6 64.6 0.72 8.7 11.9 4.6 1 1 3 4 4 4 0 Spc7 kinetochore protein DASH_Dam1 PF08653.10 ADV20095.1 - 5.6 6.8 6.5 48 3.9 0.3 4.3 3 1 1 4 4 4 0 DASH complex subunit Dam1 PRP1_N PF06424.12 ADV20096.1 - 2.6e-44 151.2 3.3 2.6e-44 151.2 3.3 2.3 2 0 0 2 2 2 1 PRP1 splicing factor, N-terminal TPR_14 PF13428.6 ADV20096.1 - 1.7e-24 84.4 29.6 0.03 15.1 0.1 14.5 6 3 9 15 15 15 10 Tetratricopeptide repeat TPR_19 PF14559.6 ADV20096.1 - 4.2e-19 68.8 23.4 8.6e-05 23.0 3.4 8.4 7 2 1 8 8 8 5 Tetratricopeptide repeat TPR_16 PF13432.6 ADV20096.1 - 2.9e-09 37.4 17.2 0.0036 17.9 0.0 6.5 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_2 PF07719.17 ADV20096.1 - 5.2e-07 29.3 6.9 2.5 8.4 0.0 8.1 9 0 0 9 9 8 2 Tetratricopeptide repeat TPR_21 PF09976.9 ADV20096.1 - 9.5e-07 28.7 17.0 3.3e-06 27.0 3.0 4.1 3 1 1 4 4 4 2 Tetratricopeptide repeat-like domain TPR_8 PF13181.6 ADV20096.1 - 1.7e-06 27.8 6.9 1.6 9.2 0.0 7.4 9 0 0 9 9 7 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ADV20096.1 - 6.9e-06 26.2 0.7 0.00021 21.5 0.2 3.1 3 0 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 ADV20096.1 - 2.7e-05 24.2 0.2 15 6.3 0.0 8.1 10 0 0 10 10 8 0 Tetratricopeptide repeat Suf PF05843.14 ADV20096.1 - 0.00048 20.2 0.1 5.6 6.9 0.0 5.2 4 1 0 5 5 5 1 Suppressor of forked protein (Suf) TPR_6 PF13174.6 ADV20096.1 - 0.001 19.6 20.4 0.86 10.4 0.0 8.1 10 0 0 10 10 8 2 Tetratricopeptide repeat FAT PF02259.23 ADV20096.1 - 0.0021 17.4 16.9 0.023 13.9 3.8 3.8 2 2 1 3 3 3 2 FAT domain TPR_11 PF13414.6 ADV20096.1 - 0.021 14.5 2.6 3.2 7.5 0.0 5.2 5 1 1 6 6 6 0 TPR repeat TPR_12 PF13424.6 ADV20096.1 - 0.09 13.1 5.2 1.9 8.8 1.3 4.6 4 1 1 5 5 5 0 Tetratricopeptide repeat Wzy_C_2 PF11846.8 ADV20096.1 - 0.33 10.8 2.3 2.7 7.9 0.1 3.3 4 1 1 5 5 5 0 Virulence factor membrane-bound polymerase, C-terminal TPR_7 PF13176.6 ADV20096.1 - 0.42 10.8 2.5 33 4.8 0.1 3.4 3 0 0 3 3 2 0 Tetratricopeptide repeat HOASN PF14515.6 ADV20096.1 - 6 7.3 9.5 26 5.3 0.7 4.1 4 0 0 4 4 3 0 Haem-oxygenase-associated N-terminal helices CsbD PF05532.12 ADV20098.1 - 1.1e-08 34.9 20.8 7.9e-05 22.5 1.6 4.2 3 1 1 4 4 4 3 CsbD-like DUF937 PF06078.11 ADV20098.1 - 0.02 15.5 5.5 0.023 15.3 5.5 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF937) Striatin PF08232.12 ADV20099.1 - 1.2e-47 162.4 0.2 1.2e-47 162.4 0.2 3.4 3 0 0 3 3 3 1 Striatin family WD40 PF00400.32 ADV20099.1 - 2.6e-32 110.3 7.6 1.6e-05 25.5 0.1 7.7 7 0 0 7 7 7 6 WD domain, G-beta repeat Ge1_WD40 PF16529.5 ADV20099.1 - 0.0013 17.8 0.0 0.16 10.9 0.0 3.0 2 2 0 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 ADV20099.1 - 0.0037 17.5 0.0 10 6.5 0.0 3.7 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ADV20099.1 - 0.007 15.1 0.5 0.47 9.0 0.3 3.1 2 1 0 2 2 2 1 Nucleoporin Nup120/160 HemY_N PF07219.13 ADV20099.1 - 0.56 10.4 2.0 1.6 9.0 2.0 1.7 1 0 0 1 1 1 0 HemY protein N-terminus TRP PF06011.12 ADV20101.1 - 1.5e-27 96.4 23.3 1.7e-26 93.0 23.3 2.1 1 1 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 ADV20101.1 - 8.1e-07 29.5 0.1 1.4e-06 28.7 0.1 1.4 1 0 0 1 1 1 1 ML-like domain EMP24_GP25L PF01105.24 ADV20102.1 - 3.9e-50 170.3 0.0 4.4e-50 170.1 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF5643 PF18705.1 ADV20102.1 - 0.083 12.9 0.1 0.11 12.4 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5643) Rpn3_C PF08375.11 ADV20103.1 - 1.2e-23 83.3 3.8 1.2e-23 83.3 3.8 2.2 2 0 0 2 2 2 1 Proteasome regulatory subunit C-terminal PCI PF01399.27 ADV20103.1 - 6.9e-20 71.5 0.0 1.9e-18 66.9 0.0 2.6 2 0 0 2 2 2 1 PCI domain TPR_2 PF07719.17 ADV20103.1 - 6.2e-05 22.8 4.4 0.0039 17.2 0.2 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 ADV20103.1 - 0.0083 16.8 2.3 0.0083 16.8 2.3 3.5 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 ADV20103.1 - 0.042 14.7 2.2 1.2 10.1 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 ADV20103.1 - 0.13 12.6 12.4 0.8 10.0 1.7 3.1 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 ADV20103.1 - 0.26 11.2 2.1 5.9 6.9 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 ADV20103.1 - 0.39 11.5 4.5 0.59 10.9 0.4 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 ADV20103.1 - 2.2 8.8 5.7 14 6.3 0.2 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat DnaJ_C PF01556.18 ADV20104.1 - 4.3e-32 111.2 0.1 6.2e-32 110.7 0.1 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 ADV20104.1 - 1.2e-19 70.2 1.3 1.7e-19 69.7 1.3 1.3 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 ADV20104.1 - 3.4e-13 49.8 15.9 6.1e-13 48.9 15.9 1.4 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 ADV20104.1 - 0.00046 20.1 17.4 0.0068 16.4 3.9 3.0 1 1 1 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein A2L_zn_ribbon PF08792.10 ADV20104.1 - 0.09 12.5 14.8 0.32 10.8 0.5 4.0 4 0 0 4 4 4 0 A2L zinc ribbon domain HypA PF01155.19 ADV20104.1 - 0.27 11.3 5.3 2.4 8.2 1.6 2.3 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Cpn60_TCP1 PF00118.24 ADV20105.1 - 9.2e-158 525.9 2.1 1e-157 525.7 2.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family FBPase PF00316.20 ADV20106.1 - 5.1e-75 251.1 1.5 6.5e-75 250.8 1.5 1.1 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain Inositol_P PF00459.25 ADV20106.1 - 0.0093 15.5 0.0 0.014 14.9 0.0 1.3 1 0 0 1 1 1 1 Inositol monophosphatase family DUF1264 PF06884.11 ADV20107.1 - 3.2e-72 241.7 0.2 4.5e-72 241.2 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1264) Myb_DNA-binding PF00249.31 ADV20108.1 - 2e-07 31.1 0.0 0.0055 16.9 0.0 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ADV20108.1 - 0.001 19.3 0.0 0.87 9.9 0.0 2.8 2 0 0 2 2 2 2 Myb-like DNA-binding domain NT5C PF06941.12 ADV20109.1 - 8.2e-10 38.8 0.0 3e-09 37.0 0.0 1.9 1 1 0 2 2 2 1 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) HAD_2 PF13419.6 ADV20109.1 - 4.7e-06 26.8 0.1 5.9e-05 23.2 0.0 2.3 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 ADV20109.1 - 0.0027 17.8 0.0 0.011 15.8 0.0 2.0 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Acid_phosphat_B PF03767.14 ADV20109.1 - 0.0032 17.1 0.0 0.005 16.5 0.0 1.4 1 0 0 1 1 1 1 HAD superfamily, subfamily IIIB (Acid phosphatase) Hydrolase PF00702.26 ADV20109.1 - 0.01 16.1 0.0 0.11 12.8 0.0 2.3 2 1 0 2 2 2 0 haloacid dehalogenase-like hydrolase Sugar_tr PF00083.24 ADV20110.1 - 7.1e-84 282.2 20.4 8.2e-84 282.1 20.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ADV20110.1 - 4.1e-31 108.2 31.0 4.4e-22 78.5 13.5 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily BCDHK_Adom3 PF10436.9 ADV20111.1 - 3.1e-65 219.0 0.0 3.9e-65 218.6 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 ADV20111.1 - 2.6e-08 34.4 0.0 5e-08 33.4 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 ADV20111.1 - 0.0072 16.2 0.0 0.013 15.4 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PI31_Prot_N PF11566.8 ADV20112.1 - 8.4e-43 146.0 0.0 1e-42 145.7 0.0 1.1 1 0 0 1 1 1 1 PI31 proteasome regulator N-terminal PI31_Prot_C PF08577.11 ADV20112.1 - 4.2e-09 37.5 11.7 4.2e-09 37.5 11.7 3.7 3 2 2 5 5 5 1 PI31 proteasome regulator AT_hook PF02178.19 ADV20113.1 - 0.99 9.5 19.7 0.63 10.1 7.2 3.5 2 0 0 2 2 2 0 AT hook motif Questin_oxidase PF14027.6 ADV20114.1 - 2e-72 244.6 0.0 2.4e-72 244.3 0.0 1.1 1 0 0 1 1 1 1 Questin oxidase-like B_lectin PF01453.24 ADV20115.1 - 0.15 12.6 0.0 0.25 11.9 0.0 1.3 1 0 0 1 1 1 0 D-mannose binding lectin ADH_zinc_N PF00107.26 ADV20116.1 - 7.8e-17 61.5 0.0 1.6e-16 60.5 0.0 1.5 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ADV20116.1 - 1e-12 49.2 0.0 2.2e-12 48.2 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ADV20116.1 - 2.9e-10 40.0 0.0 7.4e-10 38.7 0.0 1.7 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Peripla_BP_4 PF13407.6 ADV20116.1 - 0.036 13.7 0.0 0.064 12.8 0.0 1.3 1 0 0 1 1 1 0 Periplasmic binding protein domain 2-Hacid_dh_C PF02826.19 ADV20116.1 - 0.082 12.3 0.3 0.81 9.0 0.0 2.4 2 1 1 3 3 3 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain CRAL_TRIO_N PF03765.15 ADV20117.1 - 7.3e-09 35.7 1.4 1.7e-08 34.5 0.7 1.9 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain CRAL_TRIO PF00650.20 ADV20117.1 - 5.4e-06 26.2 0.0 7.8e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain ICL PF00463.21 ADV20117.1 - 0.0016 17.1 0.1 0.0019 16.7 0.1 1.1 1 0 0 1 1 1 1 Isocitrate lyase family Fungal_trans PF04082.18 ADV20118.1 - 4.4e-16 58.7 0.0 1.3e-15 57.2 0.0 1.9 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ADV20118.1 - 1.4e-11 44.3 11.3 2.5e-11 43.5 11.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 ADV20119.1 - 2.8e-30 105.4 21.2 2.8e-30 105.4 21.2 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily OATP PF03137.20 ADV20119.1 - 0.048 12.0 12.1 0.58 8.4 0.5 2.4 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Aminotran_1_2 PF00155.21 ADV20120.1 - 1.3e-55 189.0 0.0 1.6e-55 188.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 ADV20120.1 - 2.2e-05 24.0 0.0 3.8e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 ADV20120.1 - 0.00014 20.5 0.0 0.00024 19.7 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 ADV20120.1 - 0.0004 19.4 0.0 0.0012 17.8 0.0 1.7 1 1 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 ADV20120.1 - 0.00069 19.0 0.0 0.0012 18.1 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase YopE_N PF09020.10 ADV20120.1 - 0.076 13.3 0.0 0.14 12.4 0.0 1.3 1 0 0 1 1 1 0 YopE, N terminal Na_Ca_ex PF01699.24 ADV20121.1 - 5.3e-34 117.3 38.3 6.3e-17 61.9 13.9 2.3 2 0 0 2 2 2 2 Sodium/calcium exchanger protein TMEM108 PF15759.5 ADV20122.1 - 0.52 9.3 6.0 0.8 8.6 6.0 1.2 1 0 0 1 1 1 0 TMEM108 family Cyto_heme_lyase PF01265.17 ADV20123.1 - 3.2e-47 161.5 18.1 1.1e-44 153.3 8.3 3.0 2 1 0 2 2 2 2 Cytochrome c/c1 heme lyase SAM_decarbox PF01536.16 ADV20124.1 - 3e-118 394.9 0.0 3.8e-118 394.5 0.0 1.0 1 0 0 1 1 1 1 Adenosylmethionine decarboxylase zf-Tim10_DDP PF02953.15 ADV20125.1 - 6.7e-19 67.3 3.4 8.6e-19 67.0 3.4 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Phasin_2 PF09361.10 ADV20125.1 - 0.019 15.2 0.0 0.082 13.2 0.1 1.8 1 1 1 2 2 2 0 Phasin protein Tam41_Mmp37 PF09139.11 ADV20125.1 - 0.054 12.9 0.1 0.056 12.9 0.1 1.0 1 0 0 1 1 1 0 Phosphatidate cytidylyltransferase, mitochondrial KxDL PF10241.9 ADV20125.1 - 0.22 11.8 1.3 3.9 7.8 0.6 2.1 1 1 1 2 2 2 0 Uncharacterized conserved protein Forkhead PF00250.18 ADV20126.1 - 2.5e-25 88.5 0.0 5.4e-25 87.5 0.0 1.6 1 0 0 1 1 1 1 Forkhead domain SARAF PF06682.12 ADV20126.1 - 0.44 10.1 7.1 1.1 8.9 7.1 1.7 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis tRNA-synt_1g PF09334.11 ADV20128.1 - 5.7e-87 292.0 0.1 2.7e-46 158.1 0.0 2.1 1 1 1 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 ADV20128.1 - 2.5e-18 65.7 0.8 3.5e-08 32.2 0.1 2.9 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 ADV20128.1 - 2.8e-08 33.5 0.0 0.00024 20.6 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain Anticodon_1 PF08264.13 ADV20128.1 - 0.00089 19.2 0.0 0.0018 18.2 0.0 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA EF-hand_7 PF13499.6 ADV20129.1 - 2.2e-19 69.7 1.5 3.4e-09 37.0 1.0 3.2 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 ADV20129.1 - 3.7e-19 66.8 0.7 4e-05 22.9 0.2 4.2 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 ADV20129.1 - 3.5e-18 63.9 3.4 3e-05 23.6 0.3 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 ADV20129.1 - 1.8e-10 40.5 0.9 0.0025 17.6 0.2 3.8 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 ADV20129.1 - 7e-09 34.8 3.2 0.0014 18.0 0.2 3.1 3 0 0 3 3 3 2 EF hand K_channel_TID PF07941.11 ADV20129.1 - 0.64 10.5 6.8 1.8 9.1 6.8 1.7 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain Cyclase PF04199.13 ADV20130.1 - 6.1e-15 55.7 0.0 7.9e-15 55.3 0.0 1.2 1 0 0 1 1 1 1 Putative cyclase Fungal_trans PF04082.18 ADV20131.1 - 3.7e-09 36.0 0.0 5.2e-08 32.2 0.0 2.5 2 1 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ADV20131.1 - 1.6e-08 34.5 7.5 2.7e-08 33.8 7.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain 2H-phosphodiest PF08975.10 ADV20131.1 - 0.13 12.2 0.1 0.59 10.1 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1868) DUF676 PF05057.14 ADV20132.1 - 1.5e-06 27.9 0.0 3.5e-06 26.7 0.0 1.6 2 0 0 2 2 2 1 Putative serine esterase (DUF676) Abhydrolase_6 PF12697.7 ADV20132.1 - 0.0028 18.3 4.3 0.0057 17.3 4.3 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF900 PF05990.12 ADV20132.1 - 0.0064 16.0 0.0 0.021 14.3 0.0 1.7 2 0 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF900) PGAP1 PF07819.13 ADV20132.1 - 0.016 15.0 0.0 0.024 14.4 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Hydrolase_4 PF12146.8 ADV20132.1 - 0.028 13.7 0.0 0.054 12.8 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 LCAT PF02450.15 ADV20132.1 - 0.032 13.4 0.0 0.046 12.9 0.0 1.2 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase HELP PF03451.14 ADV20132.1 - 0.071 13.0 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 HELP motif DUF1749 PF08538.10 ADV20132.1 - 0.12 11.4 0.0 0.21 10.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) Dehydrin PF00257.19 ADV20133.1 - 0.0022 18.6 7.1 0.0022 18.6 7.1 5.8 2 2 2 4 4 4 1 Dehydrin MPC PF03650.13 ADV20134.1 - 2.6e-42 143.4 0.4 2.9e-42 143.3 0.4 1.0 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers Suv3_C_1 PF18147.1 ADV20134.1 - 0.1 12.5 0.0 0.23 11.4 0.0 1.6 1 0 0 1 1 1 0 Suv3 C-terminal domain 1 Epimerase PF01370.21 ADV20135.1 - 2.8e-18 66.3 0.0 3.7e-18 65.9 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ADV20135.1 - 5e-10 39.3 0.0 7e-10 38.8 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 ADV20135.1 - 1.2e-08 34.3 0.0 1.8e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 ADV20135.1 - 0.00063 19.0 0.2 0.024 13.8 0.4 2.2 1 1 1 2 2 2 1 Male sterility protein NAD_binding_10 PF13460.6 ADV20135.1 - 0.0013 18.7 0.0 0.0019 18.1 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Semialdhyde_dh PF01118.24 ADV20135.1 - 0.012 16.0 0.0 0.02 15.4 0.0 1.3 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain RmlD_sub_bind PF04321.17 ADV20135.1 - 0.12 11.5 0.0 0.22 10.6 0.0 1.5 1 1 0 1 1 1 0 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 ADV20135.1 - 0.15 11.2 0.0 0.34 10.0 0.0 1.6 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein DUF4171 PF13775.6 ADV20136.1 - 2.3 8.6 25.7 0.069 13.6 6.3 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4171) DUF668 PF05003.12 ADV20137.1 - 0.067 13.7 0.0 0.45 11.0 0.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF668) Palm_thioest PF02089.15 ADV20138.1 - 5.2e-67 226.2 0.0 6e-67 226.0 0.0 1.0 1 0 0 1 1 1 1 Palmitoyl protein thioesterase FSH1 PF03959.13 ADV20138.1 - 0.039 13.6 0.0 0.058 13.1 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase (FSH1) TPR_1 PF00515.28 ADV20139.1 - 6.7e-45 149.1 25.7 1.8e-06 27.5 0.0 9.4 9 0 0 9 9 9 9 Tetratricopeptide repeat TPR_2 PF07719.17 ADV20139.1 - 1.1e-35 118.9 25.3 0.00064 19.6 0.0 9.5 9 0 0 9 9 9 8 Tetratricopeptide repeat STI1 PF17830.1 ADV20139.1 - 2e-31 107.7 16.9 1.3e-16 60.2 5.6 3.8 3 0 0 3 3 3 2 STI1 domain TPR_16 PF13432.6 ADV20139.1 - 4.2e-24 84.9 10.2 1.7e-06 28.6 0.1 6.5 4 2 2 6 6 6 5 Tetratricopeptide repeat TPR_8 PF13181.6 ADV20139.1 - 5.7e-21 72.9 27.7 2.2e-05 24.3 0.1 10.0 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_11 PF13414.6 ADV20139.1 - 1.1e-20 73.0 22.8 7.6e-06 25.5 0.2 8.8 7 2 2 9 9 9 6 TPR repeat TPR_19 PF14559.6 ADV20139.1 - 9e-19 67.8 16.2 9.2e-07 29.3 0.0 7.5 5 3 3 8 8 8 3 Tetratricopeptide repeat TPR_14 PF13428.6 ADV20139.1 - 1.2e-17 63.1 8.8 0.15 12.9 0.0 8.7 4 3 5 9 9 9 5 Tetratricopeptide repeat TPR_12 PF13424.6 ADV20139.1 - 5.3e-17 61.9 20.4 1.3e-09 38.2 0.0 7.2 5 2 2 7 7 7 4 Tetratricopeptide repeat TPR_17 PF13431.6 ADV20139.1 - 2.2e-13 49.6 6.9 0.13 12.7 0.3 7.5 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_7 PF13176.6 ADV20139.1 - 1.3e-11 43.7 10.5 0.0004 20.2 0.0 7.2 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_9 PF13371.6 ADV20139.1 - 5.3e-11 42.5 0.7 0.47 10.6 0.0 5.5 3 2 3 6 6 6 4 Tetratricopeptide repeat TPR_10 PF13374.6 ADV20139.1 - 4.7e-10 39.0 7.9 0.036 13.9 0.0 6.9 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_6 PF13174.6 ADV20139.1 - 1.3e-06 28.7 19.3 0.73 10.6 0.0 7.9 8 0 0 8 8 7 2 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 ADV20139.1 - 0.00012 22.5 12.5 0.23 11.9 0.2 4.4 4 0 0 4 4 4 2 Alkyl sulfatase dimerisation DUF4440 PF14534.6 ADV20139.1 - 0.066 13.6 0.3 0.89 10.0 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4440) ANAPC3 PF12895.7 ADV20139.1 - 0.067 13.4 13.0 0.16 12.2 0.1 5.0 3 2 2 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 PPR PF01535.20 ADV20139.1 - 0.098 13.0 0.3 23 5.5 0.0 3.9 4 0 0 4 4 3 0 PPR repeat TPR_3 PF07720.12 ADV20139.1 - 0.17 11.9 10.4 24 5.0 0.1 5.7 5 0 0 5 5 5 0 Tetratricopeptide repeat SMBP PF16785.5 ADV20139.1 - 9.7 6.5 14.4 2 8.7 1.7 4.2 4 0 0 4 4 4 0 Small metal-binding protein FTCD_C PF04961.12 ADV20140.1 - 1.1 9.0 3.3 11 5.7 3.3 2.1 1 1 0 1 1 1 0 Formiminotransferase-cyclodeaminase ABC_tran PF00005.27 ADV20141.1 - 4.5e-45 153.5 0.3 1.1e-26 94.0 0.0 3.4 2 1 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 ADV20141.1 - 9.9e-16 58.4 0.2 0.0024 17.7 0.0 4.2 3 1 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ADV20141.1 - 3.6e-12 46.2 0.0 6.8e-07 28.9 0.0 3.4 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 ADV20141.1 - 6.5e-09 36.6 3.0 0.025 15.1 2.6 3.5 3 1 0 3 3 3 2 AAA domain Chromo PF00385.24 ADV20141.1 - 1.1e-08 34.9 0.3 2.3e-08 33.8 0.3 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain AAA_29 PF13555.6 ADV20141.1 - 7.1e-06 25.7 1.1 0.026 14.3 0.3 3.2 4 0 0 4 4 4 2 P-loop containing region of AAA domain AAA_28 PF13521.6 ADV20141.1 - 7.9e-05 23.0 0.0 0.26 11.5 0.0 2.7 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 ADV20141.1 - 0.0001 22.3 0.0 0.012 15.7 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_22 PF13401.6 ADV20141.1 - 0.00012 22.3 0.0 0.91 9.8 0.0 2.9 2 0 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 ADV20141.1 - 0.00062 19.7 0.1 0.076 12.9 0.1 2.4 2 0 0 2 2 2 1 RsgA GTPase DUF87 PF01935.17 ADV20141.1 - 0.0016 18.6 1.9 1.3 9.1 0.2 3.3 3 0 0 3 3 3 1 Helicase HerA, central domain AAA_18 PF13238.6 ADV20141.1 - 0.004 17.7 0.0 0.57 10.7 0.0 2.6 2 0 0 2 2 2 1 AAA domain 4HB PF17947.1 ADV20141.1 - 0.0082 16.2 0.8 0.023 14.7 0.0 2.1 2 0 0 2 2 1 1 Four helical bundle domain AAA_30 PF13604.6 ADV20141.1 - 0.0086 15.8 0.1 2.6 7.7 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_27 PF13514.6 ADV20141.1 - 0.012 15.2 1.1 3.4 7.2 0.0 2.8 3 0 0 3 3 3 0 AAA domain AAA_24 PF13479.6 ADV20141.1 - 0.042 13.6 0.3 1.3 8.7 0.1 2.4 2 0 0 2 2 2 0 AAA domain HEAT_EZ PF13513.6 ADV20141.1 - 0.053 14.0 0.6 15 6.2 0.0 3.3 3 0 0 3 3 2 0 HEAT-like repeat AAA_13 PF13166.6 ADV20141.1 - 0.12 11.0 0.0 8.4 4.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 ADV20141.1 - 0.14 12.5 0.0 1.8 8.9 0.0 2.5 2 0 0 2 2 2 0 AAA ATPase domain Zeta_toxin PF06414.12 ADV20141.1 - 0.14 11.4 0.6 4.5 6.5 0.0 2.9 3 0 0 3 3 3 0 Zeta toxin RNA_helicase PF00910.22 ADV20141.1 - 0.2 12.1 0.0 7.8 6.9 0.0 2.6 2 0 0 2 2 2 0 RNA helicase MeaB PF03308.16 ADV20141.1 - 0.22 10.4 6.1 0.66 8.9 0.1 3.0 4 0 0 4 4 4 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_15 PF13175.6 ADV20141.1 - 3.6 7.2 7.9 0.74 9.5 0.5 2.6 3 0 0 3 3 3 0 AAA ATPase domain MCU PF04678.13 ADV20142.1 - 7.5e-22 78.3 3.7 7.9e-22 78.2 0.0 2.1 2 0 0 2 2 2 1 Mitochondrial calcium uniporter Hid1 PF12722.7 ADV20142.1 - 9.8 4.2 5.9 16 3.4 5.9 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Ribosomal_L34 PF00468.17 ADV20143.1 - 1.6e-15 56.8 7.1 2.4e-15 56.2 7.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L34 PRP21_like_P PF12230.8 ADV20144.1 - 2.8e-67 226.8 17.2 2.8e-67 226.8 17.2 2.8 3 0 0 3 3 3 1 Pre-mRNA splicing factor PRP21 like protein Surp PF01805.20 ADV20144.1 - 2.7e-26 91.3 7.6 1.5e-13 50.5 0.1 2.8 3 0 0 3 3 3 2 Surp module ubiquitin PF00240.23 ADV20144.1 - 7.9e-07 28.7 0.0 2.7e-05 23.8 0.0 2.6 2 0 0 2 2 2 1 Ubiquitin family zf_UBZ PF18439.1 ADV20144.1 - 0.00041 19.9 0.1 0.00086 18.8 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin-Binding Zinc Finger GPW_gp25 PF04965.14 ADV20144.1 - 0.026 14.3 0.0 0.058 13.2 0.0 1.6 1 0 0 1 1 1 0 Gene 25-like lysozyme DZR PF12773.7 ADV20145.1 - 0.054 13.5 1.3 0.057 13.5 0.2 1.5 2 0 0 2 2 2 0 Double zinc ribbon Ribosomal_S3_C PF00189.20 ADV20146.1 - 2e-25 89.1 0.1 8.7e-25 87.1 0.2 1.9 2 0 0 2 2 2 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.17 ADV20146.1 - 6e-11 42.0 0.1 1.2e-10 41.0 0.1 1.5 1 0 0 1 1 1 1 KH domain UN_NPL4 PF11543.8 ADV20146.1 - 0.044 14.3 0.0 0.089 13.3 0.0 1.5 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 Coilin_N PF15862.5 ADV20146.1 - 0.16 11.8 0.0 0.23 11.3 0.0 1.2 1 0 0 1 1 1 0 Coilin N-terminus SDA1 PF05285.12 ADV20147.1 - 0.22 10.9 9.0 0.26 10.7 9.0 1.1 1 0 0 1 1 1 0 SDA1 Plasmodium_Vir PF05795.11 ADV20147.1 - 0.64 9.4 1.3 0.69 9.3 1.3 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Nucleo_P87 PF07267.11 ADV20147.1 - 1.1 8.1 3.0 1.4 7.7 3.0 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 CDC45 PF02724.14 ADV20147.1 - 1.2 7.3 5.0 1.3 7.2 5.0 1.0 1 0 0 1 1 1 0 CDC45-like protein Lipase_GDSL_2 PF13472.6 ADV20148.1 - 0.015 15.7 0.0 0.029 14.8 0.0 1.6 1 1 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family RGS PF00615.19 ADV20149.1 - 2.2e-43 147.3 0.1 5.4e-43 146.0 0.1 1.7 1 0 0 1 1 1 1 Regulator of G protein signaling domain DEP PF00610.21 ADV20149.1 - 2.6e-12 46.6 0.1 3.4e-05 23.8 0.0 3.4 3 0 0 3 3 3 3 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Gly_transf_sug PF04488.15 ADV20150.1 - 1.9e-10 41.3 0.1 3.5e-10 40.4 0.1 1.4 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Caps_synth PF05704.12 ADV20150.1 - 7e-05 22.3 0.0 0.0001 21.8 0.0 1.1 1 0 0 1 1 1 1 Capsular polysaccharide synthesis protein TcdA_TcdB PF12919.7 ADV20150.1 - 0.002 17.5 0.1 0.0042 16.4 0.0 1.5 2 0 0 2 2 2 1 TcdA/TcdB catalytic glycosyltransferase domain Pkinase PF00069.25 ADV20151.1 - 1.9e-71 240.5 0.0 4.6e-71 239.3 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV20151.1 - 2.5e-32 112.2 0.0 1.5e-30 106.3 0.0 2.3 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ADV20151.1 - 0.0012 18.2 1.6 1.6 8.0 0.7 3.0 2 1 0 2 2 2 2 Kinase-like RIO1 PF01163.22 ADV20151.1 - 0.0017 18.0 0.6 0.0029 17.2 0.6 1.4 1 0 0 1 1 1 1 RIO1 family Pkinase_fungal PF17667.1 ADV20151.1 - 0.038 12.8 3.4 0.15 10.8 3.4 1.9 1 1 0 1 1 1 0 Fungal protein kinase ABC1 PF03109.16 ADV20151.1 - 0.041 14.0 2.2 0.17 12.1 0.1 2.3 2 0 0 2 2 2 0 ABC1 family Ndc1_Nup PF09531.10 ADV20151.1 - 0.11 11.2 3.5 0.16 10.6 3.5 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup EFTUD2 PF16004.5 ADV20151.1 - 3.7 8.2 10.8 1.7 9.2 5.8 2.3 2 0 0 2 2 2 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus ADH_zinc_N PF00107.26 ADV20152.1 - 3.4e-29 101.5 0.6 5.9e-29 100.7 0.6 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ADV20152.1 - 1.8e-10 42.0 0.0 3.2e-10 41.2 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase adh_short PF00106.25 ADV20152.1 - 0.039 13.4 0.6 0.075 12.5 0.2 1.7 2 0 0 2 2 2 0 short chain dehydrogenase PC4 PF02229.16 ADV20153.1 - 8e-19 67.0 0.0 1.4e-18 66.3 0.0 1.3 1 0 0 1 1 1 1 Transcriptional Coactivator p15 (PC4) Ubie_methyltran PF01209.18 ADV20154.1 - 6.1e-75 251.5 0.0 8.3e-75 251.1 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 ADV20154.1 - 7.2e-16 58.7 0.0 1.4e-15 57.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ADV20154.1 - 6.3e-13 49.2 0.0 1.4e-12 48.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ADV20154.1 - 1.4e-10 41.8 0.0 2.4e-10 41.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ADV20154.1 - 5.6e-10 39.2 0.0 7.8e-10 38.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ADV20154.1 - 1.1e-05 25.4 0.0 1.9e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 ADV20154.1 - 0.01 15.7 0.0 0.073 12.9 0.0 2.0 2 0 0 2 2 2 0 Hypothetical methyltransferase Methyltransf_5 PF01795.19 ADV20154.1 - 0.02 14.4 0.0 0.073 12.6 0.0 1.7 1 1 1 2 2 2 0 MraW methylase family FAD_binding_3 PF01494.19 ADV20155.1 - 5.1e-09 35.8 0.0 5.1e-09 35.8 0.0 1.0 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 ADV20155.1 - 0.0001 22.5 0.0 0.00012 22.3 0.0 1.3 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 ADV20155.1 - 0.00051 19.7 0.0 0.00051 19.7 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 ADV20155.1 - 0.0075 15.5 0.0 0.0075 15.5 0.0 1.1 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.14 ADV20155.1 - 0.016 13.9 0.0 0.02 13.6 0.0 1.1 1 0 0 1 1 1 0 HI0933-like protein Pyr_redox_2 PF07992.14 ADV20155.1 - 0.017 14.3 0.0 0.018 14.3 0.0 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ADV20155.1 - 0.018 14.3 0.0 0.022 14.0 0.0 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 ADV20155.1 - 0.078 12.0 0.0 0.087 11.9 0.0 1.1 1 0 0 1 1 1 0 Lycopene cyclase protein FAD_binding_2 PF00890.24 ADV20155.1 - 0.15 11.1 0.0 0.15 11.1 0.0 1.0 1 0 0 1 1 1 0 FAD binding domain DUF2306 PF10067.9 ADV20156.1 - 0.13 12.5 2.5 0.15 12.3 1.4 1.5 1 1 1 2 2 2 0 Predicted membrane protein (DUF2306) NUC153 PF08159.12 ADV20158.1 - 1.9e-13 49.9 12.7 5.3e-13 48.5 1.2 3.7 3 0 0 3 3 3 2 NUC153 domain SAICAR_synt PF01259.18 ADV20159.1 - 1.9e-97 325.8 0.0 2.8e-97 325.3 0.0 1.3 1 0 0 1 1 1 1 SAICAR synthetase tRNA-synt_1b PF00579.25 ADV20159.1 - 2.6e-58 197.7 0.0 8.3e-58 196.0 0.0 1.8 1 1 0 1 1 1 1 tRNA synthetases class I (W and Y) Actin PF00022.19 ADV20160.1 - 1.3e-126 422.5 0.0 6.6e-126 420.2 0.0 1.8 1 1 0 1 1 1 1 Actin PROCN PF08083.11 ADV20161.1 - 3.1e-233 773.8 7.4 4.6e-233 773.2 7.4 1.3 1 0 0 1 1 1 1 PROCN (NUC071) domain PRP8_domainIV PF12134.8 ADV20161.1 - 2.2e-127 423.4 0.9 3.9e-127 422.6 0.9 1.4 1 0 0 1 1 1 1 PRP8 domain IV core PRO8NT PF08082.11 ADV20161.1 - 7.7e-85 282.4 3.0 7.7e-85 282.4 3.0 2.0 2 0 0 2 2 2 1 PRO8NT (NUC069), PrP8 N-terminal domain U6-snRNA_bdg PF10596.9 ADV20161.1 - 8e-83 276.1 0.6 4.8e-60 202.1 0.3 2.8 2 0 0 2 2 2 2 U6-snRNA interacting domain of PrP8 U5_2-snRNA_bdg PF10597.9 ADV20161.1 - 1.6e-70 235.4 0.0 3.3e-70 234.4 0.0 1.5 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 RRM_4 PF10598.9 ADV20161.1 - 2.4e-45 152.8 0.2 6e-45 151.5 0.2 1.7 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 PROCT PF08084.11 ADV20161.1 - 1.8e-42 144.2 0.1 5.7e-42 142.5 0.0 2.0 2 0 0 2 2 2 1 PROCT (NUC072) domain Hom_end_hint PF05203.16 ADV20161.1 - 8.3e-11 42.3 0.2 2.5e-10 40.7 0.0 1.8 2 0 0 2 2 2 1 Hom_end-associated Hint JAB PF01398.21 ADV20161.1 - 0.00012 22.1 0.0 0.00026 20.9 0.0 1.6 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease GIIM PF08388.11 ADV20161.1 - 0.24 11.5 0.0 0.24 11.5 0.0 2.3 2 0 0 2 2 2 0 Group II intron, maturase-specific domain Sec16_C PF12931.7 ADV20162.1 - 3.3e-70 237.1 0.0 4.7e-70 236.6 0.0 1.2 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 Sec16 PF12932.7 ADV20162.1 - 3.2e-22 79.3 0.0 1.5e-21 77.2 0.0 2.3 1 0 0 1 1 1 1 Vesicle coat trafficking protein Sec16 mid-region B12D PF06522.11 ADV20163.1 - 1.1e-19 69.9 0.1 1.5e-19 69.6 0.1 1.1 1 0 0 1 1 1 1 NADH-ubiquinone reductase complex 1 MLRQ subunit Peptidase_S8 PF00082.22 ADV20164.1 - 6e-43 147.2 1.2 9.7e-43 146.5 1.2 1.3 1 0 0 1 1 1 1 Subtilase family fn3_5 PF06280.12 ADV20164.1 - 4.2e-18 66.1 0.0 9.8e-18 64.9 0.0 1.7 1 0 0 1 1 1 1 Fn3-like domain PA PF02225.22 ADV20164.1 - 0.00056 19.9 0.0 0.0062 16.5 0.0 2.5 2 0 0 2 2 2 1 PA domain FF PF01846.19 ADV20165.1 - 2e-33 114.3 22.0 2.5e-14 53.2 0.1 4.3 4 0 0 4 4 4 3 FF domain WW PF00397.26 ADV20165.1 - 4e-10 39.6 8.1 6.3e-08 32.6 1.2 3.0 2 0 0 2 2 2 2 WW domain RhoGAP-FF1 PF16512.5 ADV20165.1 - 0.0002 22.0 6.6 0.027 15.1 3.4 3.6 1 1 2 3 3 3 2 p190-A and -B Rho GAPs FF domain APOC4 PF15119.6 ADV20165.1 - 3.9 7.8 7.7 1.6 9.0 1.9 3.0 2 1 0 2 2 2 0 Apolipoprotein C4 NT5C PF06941.12 ADV20167.1 - 0.006 16.5 0.1 0.13 12.1 0.1 2.3 1 1 0 1 1 1 1 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) Hydrolase_6 PF13344.6 ADV20167.1 - 0.013 15.6 0.0 0.022 14.8 0.0 1.3 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase 5-nucleotidase PF06189.12 ADV20167.1 - 0.23 10.4 0.0 0.44 9.4 0.0 1.4 1 0 0 1 1 1 0 5'-nucleotidase Pex24p PF06398.11 ADV20168.1 - 7e-24 84.5 5.5 4.2e-16 58.9 1.1 2.2 2 0 0 2 2 2 2 Integral peroxisomal membrane peroxin Pex2_Pex12 PF04757.14 ADV20169.1 - 3.1e-30 105.5 0.4 3.1e-30 105.5 0.4 1.4 2 0 0 2 2 2 1 Pex2 / Pex12 amino terminal region VCBS PF13517.6 ADV20170.1 - 3e-24 85.4 11.7 1e-09 38.8 0.1 5.6 4 2 1 5 5 5 4 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 ADV20170.1 - 9.1e-06 25.7 16.8 0.12 12.5 0.2 5.8 6 0 0 6 6 6 3 FG-GAP repeat Gram_pos_anchor PF00746.21 ADV20170.1 - 0.076 13.0 0.5 7.2 6.7 0.0 2.4 2 0 0 2 2 2 0 LPXTG cell wall anchor motif DEAD PF00270.29 ADV20172.1 - 1e-41 142.6 0.0 1.8e-41 141.8 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ADV20172.1 - 4.1e-25 88.3 0.0 9.2e-25 87.2 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain RasGAP PF00616.19 ADV20172.1 - 0.02 14.6 1.9 0.061 13.0 0.0 2.1 2 0 0 2 2 2 0 GTPase-activator protein for Ras-like GTPase ResIII PF04851.15 ADV20172.1 - 0.021 14.8 0.0 0.04 13.9 0.0 1.5 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit CDC45 PF02724.14 ADV20172.1 - 2.6 6.2 8.3 3.8 5.7 8.3 1.1 1 0 0 1 1 1 0 CDC45-like protein PNP_UDP_1 PF01048.20 ADV20173.1 - 1.2e-33 116.4 0.0 1.5e-33 116.0 0.0 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily Alginate_lyase PF05426.12 ADV20174.1 - 1.4e-68 231.4 7.3 2.1e-68 230.8 7.3 1.2 1 0 0 1 1 1 1 Alginate lyase TFIIIC_delta PF12657.7 ADV20175.1 - 2.4e-39 135.2 0.9 2.4e-39 135.2 0.9 2.0 2 0 0 2 2 2 1 Transcription factor IIIC subunit delta N-term AOX PF01786.17 ADV20176.1 - 2.5e-94 314.9 0.0 3.1e-94 314.6 0.0 1.1 1 0 0 1 1 1 1 Alternative oxidase COQ7 PF03232.13 ADV20176.1 - 0.011 15.5 0.0 0.021 14.6 0.0 1.4 1 0 0 1 1 1 0 Ubiquinone biosynthesis protein COQ7 Aldo_ket_red PF00248.21 ADV20177.1 - 3e-59 200.6 0.0 3.5e-59 200.4 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Frankia_peptide PF14407.6 ADV20177.1 - 0.16 12.0 0.1 1.9 8.5 0.0 2.3 2 0 0 2 2 2 0 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. Gly_transf_sug PF04488.15 ADV20178.1 - 8.5e-07 29.5 0.0 1.9e-06 28.4 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Mitofilin PF09731.9 ADV20178.1 - 1.5e-05 24.0 10.0 1.9e-05 23.7 10.0 1.1 1 0 0 1 1 1 1 Mitochondrial inner membrane protein GARP PF16731.5 ADV20178.1 - 0.01 15.5 26.8 0.018 14.8 26.8 1.3 1 0 0 1 1 1 0 Glutamic acid/alanine-rich protein of Trypanosoma GlgX_C PF18390.1 ADV20178.1 - 0.011 15.5 0.0 0.028 14.2 0.0 1.6 1 0 0 1 1 1 0 Glycogen debranching enzyme C-terminal domain RAB3GAP2_C PF14656.6 ADV20178.1 - 0.027 12.7 0.7 0.045 12.0 0.7 1.4 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit C-terminus Neur_chan_memb PF02932.16 ADV20178.1 - 0.034 14.2 0.6 0.052 13.6 0.6 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region AAA_11 PF13086.6 ADV20178.1 - 0.15 11.8 4.1 0.24 11.2 4.1 1.3 1 0 0 1 1 1 0 AAA domain SAPS PF04499.15 ADV20178.1 - 0.24 10.1 3.6 0.3 9.8 3.6 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF2514 PF10721.9 ADV20178.1 - 0.38 10.8 18.6 0.11 12.5 15.7 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2514) FAM60A PF15396.6 ADV20178.1 - 0.66 9.9 7.1 1.3 9.0 7.1 1.4 1 0 0 1 1 1 0 Protein Family FAM60A Alanine_zipper PF11839.8 ADV20178.1 - 2.2 8.7 41.4 1.9e+03 -0.7 41.4 2.4 1 1 0 1 1 1 0 Alanine-zipper, major outer membrane lipoprotein TMPIT PF07851.13 ADV20178.1 - 2.4 7.3 12.3 4.1 6.6 12.3 1.3 1 0 0 1 1 1 0 TMPIT-like protein T3SSipB PF16535.5 ADV20178.1 - 4.4 7.8 20.7 10 6.6 20.7 1.5 1 0 0 1 1 1 0 Type III cell invasion protein SipB DUF948 PF06103.11 ADV20178.1 - 8.3 6.8 5.1 35 4.7 5.1 2.0 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) zf-C2H2 PF00096.26 ADV20179.1 - 1.5e-07 31.5 15.4 0.0012 19.1 0.3 3.9 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ADV20179.1 - 8e-07 29.2 9.1 0.0029 18.0 0.7 3.7 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 ADV20179.1 - 0.0023 18.6 15.3 0.091 13.7 0.3 3.9 4 0 0 4 4 4 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 ADV20179.1 - 0.0039 17.2 4.6 0.12 12.4 0.6 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2HC_2 PF13913.6 ADV20179.1 - 0.11 12.4 0.3 0.26 11.2 0.3 1.6 1 0 0 1 1 1 0 zinc-finger of a C2HC-type zf-C2H2_aberr PF17017.5 ADV20179.1 - 0.13 12.4 4.3 2.8 8.1 0.1 2.9 1 1 2 3 3 3 0 Aberrant zinc-finger zf-C2H2_3rep PF18868.1 ADV20179.1 - 0.26 11.9 2.2 0.73 10.5 2.2 1.7 1 1 0 1 1 1 0 Zinc finger C2H2-type, 3 repeats Oxidored_FMN PF00724.20 ADV20181.1 - 4.1e-61 207.1 0.0 6.3e-61 206.5 0.0 1.2 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Rad60-SLD PF11976.8 ADV20182.1 - 3.3e-24 84.5 0.1 4.7e-21 74.4 0.1 2.4 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 ADV20182.1 - 2e-05 24.2 0.0 0.093 12.5 0.0 2.4 2 0 0 2 2 2 2 Ubiquitin family TUG-UBL1 PF11470.8 ADV20182.1 - 0.012 15.8 0.0 0.4 11.0 0.0 2.3 2 0 0 2 2 2 0 TUG ubiquitin-like domain TmoB PF06234.12 ADV20182.1 - 0.057 13.5 1.3 1.3 9.2 0.2 2.7 2 1 0 2 2 2 0 Toluene-4-monooxygenase system protein B (TmoB) SurE PF01975.17 ADV20183.1 - 8.1e-45 153.0 0.0 1e-44 152.6 0.0 1.1 1 0 0 1 1 1 1 Survival protein SurE KH_6 PF15985.5 ADV20184.1 - 0.074 13.4 0.1 0.19 12.1 0.1 1.7 1 0 0 1 1 1 0 KH domain PrmC_N PF17827.1 ADV20184.1 - 0.086 13.4 0.0 0.17 12.5 0.0 1.4 1 0 0 1 1 1 0 PrmC N-terminal domain Mito_fiss_reg PF05308.11 ADV20184.1 - 0.4 10.7 0.8 0.57 10.2 0.8 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator RRM_1 PF00076.22 ADV20185.1 - 3.5e-16 58.8 0.0 6.2e-16 58.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) U1snRNP70_N PF12220.8 ADV20185.1 - 1.7e-14 54.2 1.4 1.7e-14 54.2 1.4 2.8 2 1 1 3 3 3 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RRM_5 PF13893.6 ADV20185.1 - 0.22 11.1 0.0 0.34 10.5 0.0 1.2 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF3435 PF11917.8 ADV20185.1 - 6.2 5.6 7.4 8.6 5.2 7.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3435) GST_N_3 PF13417.6 ADV20186.1 - 2.3e-11 43.9 0.0 4.1e-11 43.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 ADV20186.1 - 7e-06 26.3 0.0 1.6e-05 25.1 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 ADV20186.1 - 8.9e-06 25.9 0.0 1.9e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 ADV20186.1 - 3.1e-05 23.9 0.0 5.1e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain ThiF PF00899.21 ADV20188.1 - 7e-112 372.7 0.0 7.7e-70 235.0 0.0 2.1 2 0 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.9 ADV20188.1 - 4.6e-88 295.4 0.2 7.8e-88 294.6 0.2 1.4 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site E1_UFD PF09358.10 ADV20188.1 - 7.7e-35 119.5 0.4 1.6e-34 118.4 0.4 1.6 1 0 0 1 1 1 1 Ubiquitin fold domain E1_FCCH PF16190.5 ADV20188.1 - 4.2e-34 116.6 0.1 9.9e-34 115.4 0.1 1.7 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain E1_4HB PF16191.5 ADV20188.1 - 5.2e-25 87.4 0.3 1.6e-24 85.9 0.3 1.9 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 four-helix bundle F-box-like PF12937.7 ADV20189.1 - 0.00035 20.4 0.1 0.00083 19.2 0.1 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ADV20189.1 - 0.041 13.8 0.1 0.26 11.2 0.1 2.3 2 0 0 2 2 2 0 F-box domain F-box_4 PF15966.5 ADV20189.1 - 0.055 13.3 0.0 0.14 12.0 0.0 1.7 1 0 0 1 1 1 0 F-box TMF_DNA_bd PF12329.8 ADV20190.1 - 0.0093 16.0 0.1 0.021 14.8 0.1 1.5 1 0 0 1 1 1 1 TATA element modulatory factor 1 DNA binding adh_short_C2 PF13561.6 ADV20191.1 - 4.6e-55 186.7 1.1 3.3e-31 108.7 0.1 2.0 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ADV20191.1 - 1e-47 162.2 2.5 1.6e-28 99.5 0.2 2.2 2 0 0 2 2 2 2 short chain dehydrogenase KR PF08659.10 ADV20191.1 - 2.2e-12 47.2 1.8 8.8e-12 45.3 0.2 2.1 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 ADV20191.1 - 8.9e-06 25.3 0.5 2.5e-05 23.9 0.1 1.8 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ADV20191.1 - 0.001 18.6 0.3 0.0018 17.8 0.0 1.5 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase THF_DHG_CYH_C PF02882.19 ADV20191.1 - 0.0019 17.5 0.1 0.0032 16.8 0.1 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 2-Hacid_dh_C PF02826.19 ADV20191.1 - 0.066 12.6 0.1 0.11 11.8 0.1 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FtsJ PF01728.19 ADV20191.1 - 0.067 13.3 0.0 0.15 12.2 0.0 1.6 2 0 0 2 2 2 0 FtsJ-like methyltransferase RmlD_sub_bind PF04321.17 ADV20191.1 - 0.12 11.5 0.1 0.2 10.7 0.1 1.4 1 0 0 1 1 1 0 RmlD substrate binding domain Alpha-amylase PF00128.24 ADV20192.1 - 4.8e-51 174.3 0.0 6.4e-51 173.9 0.0 1.1 1 0 0 1 1 1 1 Alpha amylase, catalytic domain DUF1966 PF09260.11 ADV20192.1 - 2e-21 76.0 0.1 5.2e-21 74.7 0.0 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF1966) NAD_Gly3P_dh_N PF01210.23 ADV20193.1 - 8.8e-46 155.7 0.0 2.8e-45 154.1 0.0 1.7 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.14 ADV20193.1 - 2.2e-43 147.9 0.1 3.8e-43 147.2 0.1 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus F420_oxidored PF03807.17 ADV20193.1 - 0.047 14.3 0.1 4.1 8.1 0.0 2.5 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent UDPG_MGDP_dh_C PF03720.15 ADV20193.1 - 0.074 13.5 0.0 0.14 12.6 0.0 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain PAC4 PF16093.5 ADV20194.1 - 3.8e-20 71.9 0.1 6.2e-20 71.2 0.1 1.4 1 0 0 1 1 1 1 Proteasome assembly chaperone 4 ERG4_ERG24 PF01222.17 ADV20195.1 - 2.5e-136 454.9 6.2 2.8e-136 454.7 6.2 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 ADV20195.1 - 1e-05 25.2 0.2 1e-05 25.2 0.2 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1295) PEMT PF04191.13 ADV20195.1 - 0.00029 21.2 0.7 0.001 19.4 0.0 2.4 2 0 0 2 2 2 1 Phospholipid methyltransferase ICMT PF04140.14 ADV20195.1 - 0.0044 17.4 0.0 0.012 16.0 0.0 1.8 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family DUF1304 PF06993.12 ADV20195.1 - 0.16 12.0 1.6 0.27 11.2 0.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1304) ADH_N PF08240.12 ADV20196.1 - 2.1e-27 95.2 1.0 4.8e-27 94.0 1.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ADV20196.1 - 1.2e-23 83.5 0.0 1.8e-23 82.9 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 ADV20196.1 - 1.7e-09 37.5 0.0 5.6e-05 22.7 0.0 2.2 2 0 0 2 2 2 2 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 ADV20196.1 - 3.1e-06 28.3 0.0 6.6e-06 27.2 0.0 1.6 1 1 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 ADV20196.1 - 3e-05 23.4 0.2 5.3e-05 22.6 0.2 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain UDPG_MGDP_dh_N PF03721.14 ADV20196.1 - 0.00053 19.6 0.1 0.0012 18.4 0.1 1.6 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Methyltransf_25 PF13649.6 ADV20196.1 - 0.032 14.9 0.0 0.062 14.0 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain PrmA PF06325.13 ADV20196.1 - 0.13 11.6 0.1 0.19 11.1 0.1 1.1 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) 2-Hacid_dh_C PF02826.19 ADV20196.1 - 0.17 11.2 0.0 0.31 10.4 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain SPRY PF00622.28 ADV20197.1 - 8.5e-10 38.8 0.1 1.5e-06 28.3 0.0 2.7 2 0 0 2 2 2 2 SPRY domain Drf_GBD PF06371.13 ADV20198.1 - 0.0016 18.1 0.0 0.085 12.4 0.0 2.2 2 0 0 2 2 2 2 Diaphanous GTPase-binding Domain gpW PF02831.15 ADV20198.1 - 0.13 12.1 0.0 0.32 10.9 0.0 1.6 1 0 0 1 1 1 0 gpW TIP49 PF06068.13 ADV20199.1 - 5e-155 516.0 0.0 7.2e-155 515.5 0.0 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 ADV20199.1 - 3.5e-24 84.7 0.0 6.8e-24 83.8 0.0 1.5 1 0 0 1 1 1 1 TIP49 AAA-lid domain AAA PF00004.29 ADV20199.1 - 1.9e-10 41.2 0.1 3.5e-07 30.7 0.1 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 ADV20199.1 - 2.4e-08 33.9 0.1 3.1e-05 23.8 0.0 2.6 3 0 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 ADV20199.1 - 7.4e-07 29.5 0.2 0.048 13.9 0.0 2.6 1 1 0 2 2 2 2 AAA domain AAA_5 PF07728.14 ADV20199.1 - 3.2e-06 27.2 0.1 0.0011 19.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ADV20199.1 - 4.9e-06 27.0 0.0 0.00019 21.9 0.1 2.8 2 1 0 2 2 2 1 AAA ATPase domain Mg_chelatase PF01078.21 ADV20199.1 - 0.00088 18.7 0.4 0.028 13.8 0.1 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_19 PF13245.6 ADV20199.1 - 0.0018 18.6 0.9 0.73 10.2 0.1 2.5 2 1 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 ADV20199.1 - 0.0026 17.5 0.1 0.0066 16.2 0.1 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein Sigma54_activat PF00158.26 ADV20199.1 - 0.0029 17.4 0.1 3.6 7.3 0.0 2.6 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_28 PF13521.6 ADV20199.1 - 0.0036 17.6 0.1 0.014 15.6 0.1 1.9 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 ADV20199.1 - 0.0046 17.1 0.0 0.011 15.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 ADV20199.1 - 0.0047 16.5 0.1 0.014 15.0 0.1 1.8 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 ADV20199.1 - 0.006 16.1 0.5 0.025 14.1 0.0 2.1 3 0 0 3 3 3 1 P-loop containing dynein motor region AAA_18 PF13238.6 ADV20199.1 - 0.0062 17.1 0.1 0.018 15.6 0.1 1.8 2 0 0 2 2 1 1 AAA domain AAA_14 PF13173.6 ADV20199.1 - 0.008 16.2 0.0 1.6 8.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain Sigma54_activ_2 PF14532.6 ADV20199.1 - 0.0096 16.0 0.1 0.34 11.0 0.0 2.6 3 0 0 3 3 2 1 Sigma-54 interaction domain ATPase PF06745.13 ADV20199.1 - 0.017 14.5 0.2 0.045 13.1 0.1 1.7 2 0 0 2 2 2 0 KaiC NACHT PF05729.12 ADV20199.1 - 0.051 13.5 0.0 0.093 12.6 0.0 1.4 1 0 0 1 1 1 0 NACHT domain Rad17 PF03215.15 ADV20199.1 - 0.054 13.4 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_30 PF13604.6 ADV20199.1 - 0.056 13.2 0.2 1.9 8.2 0.0 2.8 3 0 0 3 3 3 0 AAA domain RNA_helicase PF00910.22 ADV20199.1 - 0.067 13.6 0.0 0.17 12.2 0.0 1.7 1 0 0 1 1 1 0 RNA helicase PhoH PF02562.16 ADV20199.1 - 0.16 11.4 0.8 0.53 9.7 0.0 2.2 3 0 0 3 3 2 0 PhoH-like protein ResIII PF04851.15 ADV20199.1 - 0.19 11.8 0.0 2.4 8.1 0.0 2.2 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_11 PF13086.6 ADV20199.1 - 0.19 11.5 0.1 0.41 10.4 0.0 1.5 2 0 0 2 2 1 0 AAA domain Response_reg PF00072.24 ADV20200.1 - 2.1e-20 72.9 0.7 5.1e-20 71.7 0.7 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HATPase_c PF02518.26 ADV20200.1 - 4.6e-20 72.2 0.0 3.2e-19 69.5 0.0 2.3 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ADV20200.1 - 5.3e-10 39.2 0.0 4.5e-09 36.2 0.0 2.3 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain DUF979 PF06166.12 ADV20200.1 - 0.13 11.4 0.2 12 5.0 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF979) ATP-synt_C PF00137.21 ADV20200.1 - 0.13 12.6 0.7 25 5.3 0.0 2.6 2 0 0 2 2 2 0 ATP synthase subunit C Glyco_hydro_79C PF16862.5 ADV20201.1 - 7.3e-18 65.4 0.5 7.3e-18 65.4 0.5 2.6 3 0 0 3 3 3 1 Glycosyl hydrolase family 79 C-terminal beta domain Aldo_ket_red PF00248.21 ADV20202.1 - 2.7e-31 108.9 0.0 1.4e-15 57.3 0.0 2.0 1 1 1 2 2 2 2 Aldo/keto reductase family RHH_1 PF01402.21 ADV20202.1 - 0.0015 18.4 2.0 0.55 10.3 0.1 3.5 3 0 0 3 3 3 2 Ribbon-helix-helix protein, copG family eRF1_1 PF03463.15 ADV20203.1 - 5.1e-51 172.0 0.2 9.6e-51 171.1 0.2 1.5 1 0 0 1 1 1 1 eRF1 domain 1 eRF1_2 PF03464.15 ADV20203.1 - 3.1e-26 92.2 0.0 4.9e-26 91.6 0.0 1.3 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 ADV20203.1 - 3e-22 79.2 0.0 6.7e-22 78.1 0.0 1.6 1 0 0 1 1 1 1 eRF1 domain 3 Kei1 PF08552.11 ADV20204.1 - 8.2e-48 162.8 2.7 1e-47 162.5 2.7 1.1 1 0 0 1 1 1 1 Inositolphosphorylceramide synthase subunit Kei1 RDD PF06271.12 ADV20204.1 - 2 8.6 9.8 0.82 9.9 5.0 2.2 2 1 0 2 2 2 0 RDD family MCM PF00493.23 ADV20205.1 - 5.7e-95 316.7 0.1 9.2e-95 316.0 0.1 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 ADV20205.1 - 1e-31 109.4 0.0 1.8e-31 108.6 0.0 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 ADV20205.1 - 2.9e-23 82.1 1.1 5.8e-23 81.1 1.1 1.5 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 ADV20205.1 - 3.7e-16 59.6 0.7 1.5e-15 57.6 0.5 2.1 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.21 ADV20205.1 - 8.7e-08 31.8 0.0 1.3e-06 28.0 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 ADV20205.1 - 0.0033 17.3 0.0 0.0079 16.1 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 ADV20205.1 - 0.012 15.3 0.0 0.034 13.9 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain Sugar_tr PF00083.24 ADV20206.1 - 2.2e-103 346.6 30.2 2.6e-103 346.3 30.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ADV20206.1 - 1.2e-23 83.6 30.2 1.2e-23 83.6 30.2 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily RTP1_C1 PF10363.9 ADV20207.1 - 3.4e-27 94.8 0.0 1.5e-26 92.8 0.0 2.2 1 0 0 1 1 1 1 Required for nuclear transport of RNA pol II C-terminus 1 RTP1_C2 PF10304.9 ADV20207.1 - 1.3e-05 24.8 0.1 4.6e-05 23.0 0.1 2.1 1 0 0 1 1 1 1 Required for nuclear transport of RNA pol II C-terminus 2 YebG PF07130.12 ADV20207.1 - 4.6 7.2 7.8 0.35 10.8 0.2 3.0 4 0 0 4 4 4 0 YebG protein DUF3292 PF11696.8 ADV20208.1 - 3.1e-74 250.6 4.8 1.5e-73 248.3 0.3 3.1 1 1 1 2 2 2 1 Protein of unknown function (DUF3292) YlmH_RBD PF17774.1 ADV20208.1 - 0.17 12.2 0.0 0.38 11.1 0.0 1.5 1 0 0 1 1 1 0 Putative RNA-binding domain in YlmH Late_protein_L2 PF00513.18 ADV20208.1 - 3.9 6.4 9.2 0.55 9.2 4.9 1.7 2 0 0 2 2 2 0 Late Protein L2 Y_phosphatase2 PF03162.13 ADV20209.1 - 2.7e-13 49.8 0.0 5.4e-13 48.9 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family Ndc1_Nup PF09531.10 ADV20209.1 - 2.8 6.5 8.4 4.1 6.0 8.4 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup zf-RING_5 PF14634.6 ADV20210.1 - 0.014 15.3 7.7 0.049 13.6 7.7 2.0 1 1 0 1 1 1 0 zinc-RING finger domain Prok-RING_4 PF14447.6 ADV20210.1 - 0.019 14.8 7.2 0.062 13.2 7.2 1.9 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Orbi_VP5 PF00901.17 ADV20210.1 - 0.067 11.6 0.0 0.088 11.2 0.0 1.1 1 0 0 1 1 1 0 Orbivirus outer capsid protein VP5 zf-C3HC4_2 PF13923.6 ADV20210.1 - 0.18 11.7 5.3 0.81 9.6 5.2 2.3 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ADV20210.1 - 0.68 9.8 8.2 2.1 8.3 8.2 1.9 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Metallothio_Pro PF02069.16 ADV20210.1 - 8.6 6.7 10.4 0.26 11.5 1.1 2.5 2 0 0 2 2 2 0 Prokaryotic metallothionein HSP9_HSP12 PF04119.12 ADV20211.1 - 0.07 13.5 0.2 0.15 12.5 0.2 1.5 1 0 0 1 1 1 0 Heat shock protein 9/12 G-alpha PF00503.20 ADV20212.1 - 6.7e-114 380.7 0.0 7.7e-114 380.5 0.0 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ADV20212.1 - 7.9e-15 54.7 0.4 1.6e-10 40.7 0.1 2.4 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ADV20212.1 - 3.7e-06 26.5 0.1 0.00052 19.5 0.0 2.3 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 ADV20212.1 - 0.005 17.0 0.1 4.1 7.6 0.1 2.4 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 ADV20212.1 - 0.018 15.1 0.0 0.93 9.6 0.0 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_29 PF13555.6 ADV20212.1 - 0.089 12.6 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.18 ADV20212.1 - 0.096 12.0 0.0 0.18 11.1 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family Peptidase_C12 PF01088.21 ADV20213.1 - 4.3e-44 150.8 0.0 5.4e-44 150.5 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 Metallophos_2 PF12850.7 ADV20214.1 - 9.9e-16 58.4 0.0 1.3e-15 57.9 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 ADV20214.1 - 0.042 14.4 0.3 1.2 9.6 0.2 2.3 2 1 1 3 3 3 0 Calcineurin-like phosphoesterase CTD_bind PF04818.13 ADV20215.1 - 1.2e-05 26.1 0.0 3.9e-05 24.4 0.0 2.0 1 0 0 1 1 1 1 RNA polymerase II-binding domain. zf_UBZ PF18439.1 ADV20215.1 - 0.00033 20.2 1.0 0.00033 20.2 1.0 1.9 2 0 0 2 2 2 1 Ubiquitin-Binding Zinc Finger Zn-C2H2_12 PF18112.1 ADV20215.1 - 0.0015 19.0 2.8 0.14 12.6 0.1 2.4 2 0 0 2 2 2 2 Autophagy receptor zinc finger-C2H2 domain zf-C2H2_4 PF13894.6 ADV20215.1 - 0.053 14.4 3.7 0.23 12.4 0.6 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_6 PF13912.6 ADV20215.1 - 0.17 11.9 3.3 0.99 9.5 0.1 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger DUF908 PF06012.12 ADV20215.1 - 0.21 11.0 2.2 0.46 9.9 2.2 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) zf-C2H2 PF00096.26 ADV20215.1 - 0.21 12.1 1.1 11 6.7 0.1 2.6 2 0 0 2 2 2 0 Zinc finger, C2H2 type DUF3844 PF12955.7 ADV20216.1 - 2.5e-19 69.3 5.4 5.2e-19 68.3 5.4 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF3844) EGF PF00008.27 ADV20216.1 - 0.051 13.9 7.2 0.097 13.0 7.2 1.5 1 0 0 1 1 1 0 EGF-like domain EGF_2 PF07974.13 ADV20216.1 - 0.15 12.4 12.7 0.27 11.7 12.7 1.4 1 0 0 1 1 1 0 EGF-like domain UCH PF00443.29 ADV20217.1 - 8.4e-25 87.7 0.0 1.9e-24 86.5 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ADV20217.1 - 0.043 13.4 0.0 2.9 7.4 0.0 2.5 2 1 0 2 2 2 0 Ubiquitin carboxyl-terminal hydrolase Herpes_UL56 PF04534.12 ADV20217.1 - 7.6 6.0 7.3 12 5.3 0.2 3.2 3 0 0 3 3 3 0 Herpesvirus UL56 protein Ribonuclease_T2 PF00445.18 ADV20218.1 - 0.00036 20.8 0.0 0.11 12.7 0.0 2.1 1 1 0 1 1 1 1 Ribonuclease T2 family DUF1776 PF08643.10 ADV20219.1 - 0.031 13.6 0.0 0.059 12.7 0.0 1.4 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) EI24 PF07264.11 ADV20220.1 - 1.2e-24 87.5 11.0 1.7e-24 87.0 11.0 1.2 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) DUF4271 PF14093.6 ADV20220.1 - 0.03 14.2 15.7 0.039 13.9 10.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4271) DUF389 PF04087.14 ADV20220.1 - 0.18 11.9 2.3 6.4 6.8 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF389) Zn_clus PF00172.18 ADV20221.1 - 0.0011 19.0 9.4 0.0035 17.4 9.4 1.8 1 1 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Lar_restr_allev PF14354.6 ADV20222.1 - 0.031 14.6 0.5 0.058 13.8 0.5 1.4 1 0 0 1 1 1 0 Restriction alleviation protein Lar Adaptin_N PF01602.20 ADV20223.1 - 1.3e-142 476.0 8.9 1.6e-142 475.8 8.9 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.20 ADV20223.1 - 3.8e-23 81.9 1.2 8e-23 80.9 1.2 1.6 1 0 0 1 1 1 1 Adaptin C-terminal domain Cnd1 PF12717.7 ADV20223.1 - 5.2e-07 29.9 7.0 0.00021 21.4 0.2 3.5 4 0 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 ADV20223.1 - 0.0012 19.2 2.8 2.1 8.8 0.0 4.2 4 0 0 4 4 4 1 HEAT repeats HEAT PF02985.22 ADV20223.1 - 0.012 15.8 0.3 40 4.8 0.0 4.5 4 0 0 4 4 4 0 HEAT repeat Peptidase_M73 PF12389.8 ADV20223.1 - 0.046 13.6 0.1 0.12 12.2 0.1 1.6 1 0 0 1 1 1 0 Camelysin metallo-endopeptidase RICTOR_M PF14666.6 ADV20223.1 - 0.077 12.8 0.8 0.35 10.7 0.1 2.5 2 1 1 3 3 3 0 Rapamycin-insensitive companion of mTOR, middle domain RIX1 PF08167.12 ADV20223.1 - 0.11 12.2 2.8 0.54 10.0 0.1 3.2 3 1 0 3 3 3 0 rRNA processing/ribosome biogenesis LAG1-DNAbind PF09271.11 ADV20224.1 - 4.4e-24 85.8 0.0 3.5e-14 53.7 0.0 4.7 3 2 0 3 3 3 2 LAG1, DNA binding BTD PF09270.10 ADV20224.1 - 2.3e-06 27.9 0.0 4.6e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 Beta-trefoil DNA-binding domain Herpes_LMP1 PF05297.11 ADV20224.1 - 0.3 10.2 3.9 0.52 9.5 3.9 1.3 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) CactinC_cactus PF09732.9 ADV20225.1 - 3.2e-57 191.9 7.0 5.8e-57 191.0 7.0 1.5 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein Cactin_mid PF10312.9 ADV20225.1 - 3.8e-56 190.0 0.8 1.7e-55 187.9 0.8 2.2 1 0 0 1 1 1 1 Conserved mid region of cactin LDB19 PF13002.7 ADV20226.1 - 0.015 15.0 0.1 0.041 13.6 0.0 1.7 2 0 0 2 2 2 0 Arrestin_N terminal like Arrestin_N PF00339.29 ADV20226.1 - 0.087 12.9 0.0 0.21 11.6 0.0 1.7 1 1 0 1 1 1 0 Arrestin (or S-antigen), N-terminal domain ESSS PF10183.9 ADV20227.1 - 2.4e-13 50.2 0.0 2.9e-13 49.9 0.0 1.1 1 0 0 1 1 1 1 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) FAD_binding_6 PF00970.24 ADV20228.1 - 1.3e-07 31.9 0.1 3.9e-07 30.3 0.0 1.8 2 0 0 2 2 2 1 Oxidoreductase FAD-binding domain zf-C2H2_aberr PF17017.5 ADV20229.1 - 3.2e-05 24.2 1.7 0.24 11.5 0.0 2.2 2 0 0 2 2 2 2 Aberrant zinc-finger zf-C2H2 PF00096.26 ADV20229.1 - 0.00053 20.3 1.4 0.18 12.3 0.1 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type UCH PF00443.29 ADV20231.1 - 5.2e-27 95.0 0.2 1.9e-26 93.1 0.1 1.9 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase RPT PF13446.6 ADV20231.1 - 2.6e-23 81.7 0.0 1.5e-12 47.2 0.0 3.8 3 1 0 3 3 3 2 A repeated domain in UCH-protein UCH_1 PF13423.6 ADV20231.1 - 0.0064 16.1 0.0 0.014 15.0 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase APG6_N PF17675.1 ADV20231.1 - 0.011 16.2 1.4 0.042 14.4 1.4 2.0 1 0 0 1 1 1 0 Apg6 coiled-coil region DUF4606 PF15379.6 ADV20231.1 - 0.042 14.1 0.3 0.19 12.0 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4606) Uds1 PF15456.6 ADV20231.1 - 0.11 12.7 0.2 0.3 11.2 0.2 1.7 1 0 0 1 1 1 0 Up-regulated During Septation PQ-loop PF04193.14 ADV20232.1 - 2.9e-28 97.4 10.7 9.1e-14 51.0 2.0 2.9 2 0 0 2 2 2 2 PQ loop repeat DUF4199 PF13858.6 ADV20232.1 - 3.9 7.9 15.0 14 6.0 0.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4199) Peptidase_S9 PF00326.21 ADV20234.1 - 5.1e-05 22.9 0.0 7.6e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_2 PF02230.16 ADV20234.1 - 0.0078 16.0 0.0 0.023 14.5 0.0 1.8 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase Synaptobrevin PF00957.21 ADV20235.1 - 4.4e-30 103.3 0.0 6.2e-30 102.8 0.0 1.2 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 ADV20235.1 - 6.1e-22 77.5 0.0 1.6e-21 76.1 0.0 1.6 2 0 0 2 2 2 1 Regulated-SNARE-like domain tRNA-synt_1g PF09334.11 ADV20235.1 - 0.099 11.4 0.0 0.16 10.7 0.0 1.2 1 0 0 1 1 1 0 tRNA synthetases class I (M) SPT2 PF08243.11 ADV20236.1 - 3.5e-16 59.7 11.2 3.5e-16 59.7 11.2 2.8 2 0 0 2 2 2 1 SPT2 chromatin protein Seipin PF06775.14 ADV20237.1 - 1.1e-06 28.9 0.0 2.3e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 Putative adipose-regulatory protein (Seipin) DUF155 PF02582.14 ADV20238.1 - 3.2e-43 147.9 0.0 4.7e-43 147.3 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 Methyltransf_16 PF10294.9 ADV20239.1 - 1.9e-10 40.7 0.5 3.8e-05 23.5 0.0 2.5 2 1 0 2 2 2 2 Lysine methyltransferase Methyltransf_25 PF13649.6 ADV20239.1 - 0.15 12.7 0.0 0.32 11.7 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain DnaJ PF00226.31 ADV20240.1 - 7.8e-05 22.7 0.0 0.00011 22.3 0.0 1.2 1 0 0 1 1 1 1 DnaJ domain Pam16 PF03656.13 ADV20240.1 - 0.00017 21.6 0.0 0.00018 21.5 0.0 1.1 1 0 0 1 1 1 1 Pam16 Dus PF01207.17 ADV20241.1 - 7.4e-54 182.9 0.0 2.7e-48 164.7 0.0 2.0 2 0 0 2 2 2 2 Dihydrouridine synthase (Dus) AflR PF08493.10 ADV20241.1 - 0.17 11.4 0.2 0.28 10.6 0.2 1.3 1 0 0 1 1 1 0 Aflatoxin regulatory protein Aminotran_1_2 PF00155.21 ADV20242.1 - 3.7e-34 118.5 0.0 4.2e-34 118.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DUF829 PF05705.14 ADV20242.1 - 0.12 12.3 0.0 12 5.7 0.0 2.2 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF829) Aconitase PF00330.20 ADV20243.1 - 5e-159 530.2 0.0 6e-159 529.9 0.0 1.0 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 ADV20243.1 - 6.1e-39 133.3 0.0 1.1e-38 132.5 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain tRNA-synt_1 PF00133.22 ADV20244.1 - 7.1e-219 728.0 0.0 1e-218 727.5 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 ADV20244.1 - 1.1e-23 83.8 0.0 2e-22 79.8 0.0 2.2 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 ADV20244.1 - 1.2e-14 53.9 1.0 6.3e-05 21.9 0.1 3.8 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 ADV20244.1 - 0.019 14.3 0.0 0.036 13.4 0.0 1.4 1 0 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain ARID PF01388.21 ADV20245.1 - 0.017 15.8 0.0 0.046 14.4 0.0 1.8 1 0 0 1 1 1 0 ARID/BRIGHT DNA binding domain zf-CCHC PF00098.23 ADV20246.1 - 9.4e-10 38.1 50.5 0.00031 20.7 3.8 5.6 5 1 0 5 5 5 4 Zinc knuckle zf-CCHC_4 PF14392.6 ADV20246.1 - 1.7e-05 24.4 27.4 0.026 14.3 1.6 5.2 3 1 2 5 5 5 4 Zinc knuckle RasGEF PF00617.19 ADV20247.1 - 2.1e-30 106.2 0.0 5.4e-30 104.9 0.0 1.7 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ADV20247.1 - 2.2e-09 37.5 0.3 4.8e-09 36.4 0.3 1.6 1 0 0 1 1 1 1 RasGEF N-terminal motif Ras PF00071.22 ADV20247.1 - 0.0002 21.0 0.0 0.0087 15.7 0.0 2.3 2 0 0 2 2 2 1 Ras family AAA_16 PF13191.6 ADV20247.1 - 0.01 16.2 0.1 0.099 13.0 0.0 2.5 2 0 0 2 2 2 0 AAA ATPase domain Peptidase_M24 PF00557.24 ADV20248.1 - 4.7e-46 157.1 0.0 5.4e-46 156.9 0.0 1.0 1 0 0 1 1 1 1 Metallopeptidase family M24 DUF1840 PF08895.11 ADV20248.1 - 0.058 13.7 0.1 0.092 13.1 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1840) NAD_binding_2 PF03446.15 ADV20249.1 - 8.1e-15 55.3 0.0 1.3e-14 54.7 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 ADV20249.1 - 9.5e-07 29.1 0.0 2.7e-06 27.6 0.0 1.8 1 1 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Shikimate_DH PF01488.20 ADV20249.1 - 0.00047 20.2 0.0 0.0034 17.4 0.0 2.1 1 1 1 2 2 2 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 ADV20249.1 - 0.0081 16.7 0.0 0.016 15.7 0.0 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.19 ADV20249.1 - 0.031 13.6 0.0 0.044 13.1 0.0 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain CAP_N PF01213.19 ADV20250.1 - 0.03 13.8 0.4 0.042 13.3 0.4 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal DUF4050 PF13259.6 ADV20250.1 - 0.091 13.1 0.8 0.15 12.4 0.0 1.8 3 0 0 3 3 3 0 Protein of unknown function (DUF4050) VlpA_repeat PF04649.12 ADV20250.1 - 0.13 12.5 1.3 0.29 11.4 1.3 1.6 1 0 0 1 1 1 0 Mycoplasma hyorhinis VlpA repeat YL1_C PF08265.11 ADV20251.1 - 1.7e-12 46.9 0.0 3.4e-12 45.9 0.0 1.5 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain CDC27 PF09507.10 ADV20251.1 - 0.84 9.0 9.5 0.52 9.6 7.6 1.3 1 1 0 1 1 1 0 DNA polymerase subunit Cdc27 TPP_enzyme_N PF02776.18 ADV20252.1 - 1.5e-53 180.9 0.0 2.8e-53 180.1 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 ADV20252.1 - 5.9e-47 159.3 0.0 1.4e-45 154.8 0.0 2.5 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 ADV20252.1 - 4.3e-41 139.9 0.1 1e-40 138.7 0.1 1.7 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain CO_dh PF02552.16 ADV20252.1 - 0.0074 16.1 0.0 0.013 15.2 0.0 1.3 1 0 0 1 1 1 1 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit PRK PF00485.18 ADV20253.1 - 3e-06 27.1 0.0 8.8e-06 25.6 0.0 1.8 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.6 ADV20253.1 - 0.00028 21.5 0.0 0.0044 17.6 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 ADV20253.1 - 0.0056 16.8 0.0 2.1 8.5 0.0 2.3 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 ADV20253.1 - 0.13 12.7 0.0 0.25 11.7 0.0 1.5 1 0 0 1 1 1 0 RNA helicase S1-P1_nuclease PF02265.16 ADV20254.1 - 5.2e-57 193.5 0.0 2.2e-50 171.9 0.0 2.1 1 1 1 2 2 2 2 S1/P1 Nuclease DSPc PF00782.20 ADV20255.1 - 1.4e-18 67.0 0.0 2.1e-18 66.4 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Init_tRNA_PT PF04179.12 ADV20255.1 - 0.00013 22.2 0.0 0.00016 21.9 0.0 1.3 1 0 0 1 1 1 1 Rit1 DUSP-like domain CCDC158 PF15921.5 ADV20257.1 - 2.7 5.7 15.9 3.3 5.4 15.9 1.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 158 Tmemb_cc2 PF10267.9 ADV20257.1 - 8.5 5.4 8.8 11 5.1 8.8 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein NUDIX PF00293.28 ADV20258.1 - 2e-26 92.6 0.0 2.8e-26 92.1 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain PIN_4 PF13638.6 ADV20259.1 - 9.7e-24 84.1 0.0 1.9e-23 83.2 0.0 1.5 1 0 0 1 1 1 1 PIN domain PIN_9 PF18477.1 ADV20259.1 - 0.12 12.7 0.1 6.8 7.0 0.0 2.4 2 0 0 2 2 2 0 PIN like domain ADH_zinc_N PF00107.26 ADV20261.1 - 2.6e-22 79.2 0.0 4e-22 78.6 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ADV20261.1 - 3.1e-22 78.5 1.3 4.6e-21 74.7 1.3 2.2 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Glu_dehyd_C PF16912.5 ADV20261.1 - 4.7e-09 36.0 0.1 0.0012 18.3 0.1 2.4 2 0 0 2 2 2 2 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 ADV20261.1 - 1.6e-05 26.0 0.0 0.00015 22.8 0.0 2.4 2 1 0 2 2 2 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 ADV20261.1 - 2.5e-05 23.7 0.2 4e-05 23.0 0.2 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Methyltransf_25 PF13649.6 ADV20261.1 - 0.012 16.4 0.0 0.029 15.1 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain UDPG_MGDP_dh_N PF03721.14 ADV20261.1 - 0.031 13.8 0.1 0.052 13.1 0.1 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain PrmA PF06325.13 ADV20261.1 - 0.04 13.3 0.2 0.066 12.6 0.2 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) 2-Hacid_dh_C PF02826.19 ADV20261.1 - 0.096 12.0 0.1 0.16 11.3 0.1 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain MPC PF03650.13 ADV20262.1 - 1.8e-32 111.7 0.3 2e-32 111.6 0.3 1.1 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers DUF3684 PF12449.8 ADV20263.1 - 0 1098.2 0.0 0 1097.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3684) HATPase_c_3 PF13589.6 ADV20263.1 - 0.065 13.1 0.0 0.2 11.5 0.0 1.9 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DHHC PF01529.20 ADV20264.1 - 3.2e-29 101.7 8.2 3.2e-29 101.7 8.2 1.8 2 0 0 2 2 2 1 DHHC palmitoyltransferase DUF35_N PF12172.8 ADV20264.1 - 0.31 11.0 6.1 0.68 9.9 6.1 1.5 1 0 0 1 1 1 0 Rubredoxin-like zinc ribbon domain (DUF35_N) UQ_con PF00179.26 ADV20265.1 - 9.7e-14 51.2 0.0 1.5e-13 50.6 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme BRE PF06113.12 ADV20265.1 - 0.04 12.8 0.1 0.052 12.4 0.1 1.1 1 0 0 1 1 1 0 Brain and reproductive organ-expressed protein (BRE) TRAP_alpha PF03896.16 ADV20267.1 - 1.7e-10 40.6 0.0 2.1e-10 40.3 0.0 1.1 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit PgaD PF13994.6 ADV20267.1 - 0.0077 16.3 0.0 0.012 15.6 0.0 1.2 1 0 0 1 1 1 1 PgaD-like protein MAM33 PF02330.16 ADV20268.1 - 1.2e-55 188.7 0.0 1.4e-55 188.5 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial glycoprotein DUF3391 PF11871.8 ADV20269.1 - 2.6 8.6 6.0 15 6.1 1.7 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3391) DUF5321 PF17254.2 ADV20271.1 - 1.7e-09 37.3 0.5 4e-09 36.1 0.0 1.7 2 0 0 2 2 2 1 Family of unknown function (DUF5321) DUF2087 PF09860.9 ADV20271.1 - 0.087 13.0 0.1 0.21 11.8 0.1 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2087) bZIP_1 PF00170.21 ADV20272.1 - 4.9e-09 36.2 12.4 1.1e-08 35.1 12.4 1.5 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 ADV20272.1 - 0.018 15.1 12.3 0.018 15.1 12.3 2.3 2 0 0 2 2 2 0 Basic region leucine zipper Dynactin_p22 PF07426.11 ADV20272.1 - 0.059 13.2 0.2 0.097 12.5 0.2 1.3 1 0 0 1 1 1 0 Dynactin subunit p22 bZIP_Maf PF03131.17 ADV20272.1 - 0.1 13.1 7.9 0.23 12.0 7.9 1.5 1 0 0 1 1 1 0 bZIP Maf transcription factor SHE3 PF17078.5 ADV20272.1 - 0.22 11.2 4.7 0.42 10.3 4.7 1.3 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 Spt5_N PF11942.8 ADV20272.1 - 1.3 10.1 7.2 3.9 8.5 7.2 1.8 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal Ammonium_transp PF00909.21 ADV20273.1 - 4.9e-112 374.5 25.3 5.8e-112 374.3 25.3 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family RTX PF02382.15 ADV20273.1 - 1.2 8.8 5.3 2 8.0 5.3 1.2 1 0 0 1 1 1 0 N-terminal domain in RTX protein Ribosomal_L7Ae PF01248.26 ADV20274.1 - 1.2e-22 79.4 0.0 1.4e-22 79.2 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PEX11 PF05648.14 ADV20275.1 - 4.1e-41 140.9 0.2 4.8e-41 140.7 0.2 1.1 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) DUF4282 PF14110.6 ADV20275.1 - 0.079 13.7 0.1 0.14 12.9 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4282) DUF1748 PF08520.10 ADV20276.1 - 1.9e-21 75.7 0.3 2.2e-21 75.5 0.3 1.0 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1748) Lactamase_B_2 PF12706.7 ADV20277.1 - 2e-14 53.6 0.0 3.3e-13 49.6 0.0 2.7 1 1 1 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 ADV20277.1 - 0.041 13.8 0.0 0.18 11.7 0.0 2.0 1 1 0 1 1 1 0 Beta-lactamase superfamily domain JAB PF01398.21 ADV20278.1 - 2.1e-33 114.8 0.1 4.2e-33 113.8 0.1 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 ADV20278.1 - 7.9e-15 55.3 1.0 1.3e-14 54.6 1.0 1.4 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function Prok-JAB PF14464.6 ADV20278.1 - 8.7e-06 25.5 0.0 1.6e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain DUF5624 PF18538.1 ADV20278.1 - 0.045 13.8 0.1 0.094 12.8 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5624) G6PD_bact PF10786.9 ADV20278.1 - 0.14 11.7 0.2 0.21 11.1 0.2 1.2 1 0 0 1 1 1 0 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) Ferric_reduct PF01794.19 ADV20281.1 - 1.3e-20 73.8 7.0 1.3e-20 73.8 7.0 2.5 2 1 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 ADV20281.1 - 5.6e-10 39.3 0.0 1.1e-09 38.4 0.0 1.4 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 ADV20281.1 - 2.3e-08 34.3 0.0 2.8e-06 27.5 0.0 2.3 2 0 0 2 2 2 2 Ferric reductase NAD binding domain CNH PF00780.22 ADV20282.1 - 6.4e-06 26.0 0.0 1.4e-05 24.9 0.0 1.4 1 1 0 1 1 1 1 CNH domain Vps39_2 PF10367.9 ADV20282.1 - 1.3e-05 25.6 0.0 0.00028 21.3 0.0 2.7 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 2 ANAPC3 PF12895.7 ADV20282.1 - 0.077 13.2 0.0 1.1 9.5 0.0 2.3 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TetR_C_24 PF17932.1 ADV20282.1 - 0.12 12.7 0.1 0.45 10.8 0.0 2.0 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain DUF4148 PF13663.6 ADV20283.1 - 0.012 15.8 2.5 0.05 13.8 2.5 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4148) SMP_2 PF10144.9 ADV20283.1 - 0.049 13.3 0.3 0.064 12.9 0.3 1.2 1 0 0 1 1 1 0 Bacterial virulence factor haemolysin CBP_BcsG PF11658.8 ADV20283.1 - 0.075 11.4 0.0 0.087 11.2 0.0 1.0 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG Amnionless PF14828.6 ADV20283.1 - 0.16 10.8 0.0 0.17 10.7 0.0 1.1 1 0 0 1 1 1 0 Amnionless DUF1180 PF06679.12 ADV20283.1 - 1.3 9.5 4.7 0.34 11.3 1.0 1.8 1 1 0 2 2 2 0 Protein of unknown function (DUF1180) Ran_BP1 PF00638.18 ADV20284.1 - 2.4e-12 47.2 0.2 5.4e-12 46.0 0.2 1.6 1 0 0 1 1 1 1 RanBP1 domain NUP50 PF08911.11 ADV20284.1 - 2.4e-09 37.7 1.3 2.4e-09 37.7 1.3 7.0 4 4 1 5 5 5 1 NUP50 (Nucleoporin 50 kDa) AAA PF00004.29 ADV20285.1 - 2.5e-05 24.7 0.3 0.00099 19.5 0.1 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.20 ADV20285.1 - 0.0004 19.6 0.0 0.00067 18.8 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_16 PF13191.6 ADV20285.1 - 0.003 17.9 0.4 0.052 13.9 0.4 2.5 1 1 0 1 1 1 1 AAA ATPase domain Rad17 PF03215.15 ADV20285.1 - 0.0053 16.7 0.0 0.053 13.5 0.0 2.4 3 0 0 3 3 3 1 Rad17 P-loop domain AAA_18 PF13238.6 ADV20285.1 - 0.024 15.2 0.0 0.1 13.2 0.0 2.0 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 ADV20285.1 - 0.029 14.7 0.1 0.52 10.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 ADV20285.1 - 0.032 14.2 0.0 0.082 12.9 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE TIP49 PF06068.13 ADV20285.1 - 0.051 12.8 0.0 0.14 11.4 0.0 1.6 2 0 0 2 2 2 0 TIP49 P-loop domain AAA_5 PF07728.14 ADV20285.1 - 0.063 13.3 0.1 0.12 12.3 0.1 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_29 PF13555.6 ADV20285.1 - 0.1 12.4 0.1 0.26 11.0 0.0 1.7 2 0 0 2 2 2 0 P-loop containing region of AAA domain DUF2075 PF09848.9 ADV20285.1 - 0.11 11.7 0.1 0.18 11.0 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_7 PF12775.7 ADV20285.1 - 0.16 11.5 0.0 0.33 10.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF815 PF05673.13 ADV20285.1 - 0.19 10.9 0.0 0.41 9.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) DEAD PF00270.29 ADV20285.1 - 0.19 11.5 0.1 1.1 9.0 0.1 2.0 2 0 0 2 2 2 0 DEAD/DEAH box helicase Exo_endo_phos PF03372.23 ADV20287.1 - 8.3e-11 41.8 0.0 1.5e-10 41.0 0.0 1.4 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Fe-ADH PF00465.19 ADV20288.1 - 5.5e-87 291.9 0.0 7.1e-87 291.6 0.0 1.1 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 ADV20288.1 - 9e-11 41.9 0.0 5.9e-06 26.2 0.0 2.2 2 0 0 2 2 2 2 Iron-containing alcohol dehydrogenase Sas10_Utp3 PF04000.15 ADV20289.1 - 2.3e-16 60.2 0.1 4.1e-16 59.4 0.1 1.4 1 0 0 1 1 1 1 Sas10/Utp3/C1D family GATA PF00320.27 ADV20290.1 - 1.6e-18 66.0 2.3 3.4e-18 64.9 2.3 1.6 1 0 0 1 1 1 1 GATA zinc finger DUF1752 PF08550.10 ADV20290.1 - 8.6e-12 44.7 0.6 2.1e-11 43.4 0.6 1.7 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) DUF1077 PF06417.12 ADV20291.1 - 4.1e-43 146.1 0.0 5.4e-43 145.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) MOZART1 PF12554.8 ADV20292.1 - 4e-22 77.7 0.1 5e-22 77.4 0.1 1.1 1 0 0 1 1 1 1 Mitotic-spindle organizing gamma-tubulin ring associated Med10 PF09748.9 ADV20292.1 - 0.097 12.6 0.0 0.11 12.4 0.0 1.1 1 0 0 1 1 1 0 Transcription factor subunit Med10 of Mediator complex Herpes_UL49_5 PF05702.11 ADV20293.1 - 0.042 13.9 0.0 0.042 13.9 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus UL49.5 envelope/tegument protein Cyclin_N PF00134.23 ADV20294.1 - 5e-10 39.2 0.0 1e-09 38.2 0.0 1.5 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin PF08613.11 ADV20294.1 - 4.1e-06 27.3 0.1 1.1e-05 25.9 0.1 1.8 1 1 0 1 1 1 1 Cyclin CLTH PF10607.9 ADV20295.1 - 3.2e-36 124.5 0.0 5.5e-36 123.7 0.0 1.3 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain IMS PF00817.20 ADV20296.1 - 6.1e-29 100.9 0.0 1.4e-28 99.7 0.0 1.7 1 0 0 1 1 1 1 impB/mucB/samB family REV1_C PF16727.5 ADV20296.1 - 3.5e-16 59.4 2.7 8.3e-16 58.2 2.7 1.7 1 0 0 1 1 1 1 DNA repair protein REV1 C-terminal domain IMS_C PF11799.8 ADV20296.1 - 7.1e-14 52.5 0.0 2.6e-13 50.7 0.0 1.9 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain BRCT_2 PF16589.5 ADV20296.1 - 4.2e-11 43.1 0.0 8.9e-11 42.1 0.0 1.6 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain UBM PF14377.6 ADV20296.1 - 1.3e-08 34.0 0.0 0.0044 16.4 0.0 3.0 2 0 0 2 2 2 2 Ubiquitin binding region DUF1805 PF08827.11 ADV20296.1 - 0.044 14.1 0.2 1 9.7 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1805) IMS_HHH PF11798.8 ADV20296.1 - 0.13 12.7 0.0 0.37 11.2 0.0 1.8 1 0 0 1 1 1 0 IMS family HHH motif Peptidase_M20 PF01546.28 ADV20297.1 - 8.4e-36 123.6 0.0 1.1e-35 123.3 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 ADV20297.1 - 4.3e-10 39.5 0.0 7.7e-10 38.7 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 ADV20297.1 - 0.065 12.9 0.0 0.15 11.7 0.0 1.6 1 0 0 1 1 1 0 Peptidase family M28 GCP_C_terminal PF04130.13 ADV20298.1 - 4.6e-39 134.7 0.0 8.7e-39 133.8 0.0 1.4 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 ADV20298.1 - 9.2e-09 35.3 0.0 2.5e-08 33.9 0.0 1.7 1 1 0 1 1 1 1 Gamma tubulin complex component N-terminal Kinesin PF00225.23 ADV20299.1 - 1.7e-92 309.9 0.1 2.2e-48 164.9 0.0 2.7 2 0 0 2 2 2 2 Kinesin motor domain Microtub_bd PF16796.5 ADV20299.1 - 1.6e-15 57.4 0.0 6.3e-15 55.4 0.0 2.1 1 0 0 1 1 1 1 Microtubule binding TolA_bind_tri PF16331.5 ADV20299.1 - 0.00061 19.8 2.5 0.00061 19.8 2.5 5.8 5 0 0 5 5 5 1 TolA binding protein trimerisation PTR PF12789.7 ADV20299.1 - 3.3 7.8 5.4 1.8 8.7 0.1 3.4 4 0 0 4 4 4 0 Phage tail repeat like Nup54_57_C PF18570.1 ADV20299.1 - 8.5 6.1 8.2 1.3 8.7 0.8 3.4 3 0 0 3 3 3 0 NUP57/Nup54 C-terminal domain UPF0139 PF03669.13 ADV20300.1 - 0.00053 19.8 0.0 0.00063 19.6 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0139) Skp1_POZ PF03931.15 ADV20301.1 - 3.6e-09 36.7 0.0 6.9e-09 35.8 0.0 1.5 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain DUF496 PF04363.12 ADV20301.1 - 0.046 13.7 0.0 0.065 13.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF496) EAP30 PF04157.16 ADV20302.1 - 3.4e-27 95.3 0.0 4.2e-27 95.0 0.0 1.1 1 0 0 1 1 1 1 EAP30/Vps36 family zf-RanBP PF00641.18 ADV20302.1 - 2.1e-05 23.8 8.2 0.021 14.1 2.5 2.4 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others Vps36-NZF-N PF16988.5 ADV20302.1 - 0.017 14.5 0.2 0.017 14.5 0.2 2.7 2 1 0 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain zf-Sec23_Sec24 PF04810.15 ADV20302.1 - 0.029 14.4 2.9 4.2 7.5 0.1 2.5 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger OrfB_Zn_ribbon PF07282.11 ADV20302.1 - 0.33 10.9 2.0 0.79 9.7 0.5 2.3 2 0 0 2 2 2 0 Putative transposase DNA-binding domain RNA_POL_M_15KD PF02150.16 ADV20302.1 - 0.38 10.7 1.4 1.5 8.7 0.1 2.3 2 0 0 2 2 2 0 RNA polymerases M/15 Kd subunit DZR PF12773.7 ADV20302.1 - 2.7 8.1 6.4 1.4 9.0 0.5 2.2 1 1 2 3 3 3 0 Double zinc ribbon TMEM239 PF15841.5 ADV20303.1 - 1.4 8.8 6.4 1.5 8.7 4.5 1.8 2 0 0 2 2 2 0 Transmembrane protein 239 family Cpn60_TCP1 PF00118.24 ADV20304.1 - 3.6e-156 520.6 2.7 4.1e-156 520.4 2.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family PNTB_4TM PF12769.7 ADV20304.1 - 0.035 14.6 0.0 1.4 9.4 0.1 2.6 2 0 0 2 2 2 0 4TM region of pyridine nucleotide transhydrogenase, mitoch MFS_1 PF07690.16 ADV20305.1 - 1.4e-17 63.7 51.0 4.8e-17 61.9 51.0 1.9 1 1 0 1 1 1 1 Major Facilitator Superfamily TPR_1 PF00515.28 ADV20306.1 - 2.2e-28 96.8 0.6 3.5e-10 39.3 0.0 3.4 2 1 1 3 3 3 3 Tetratricopeptide repeat SGTA_dimer PF16546.5 ADV20306.1 - 7.8e-26 89.7 0.8 7.8e-26 89.7 0.8 2.3 3 0 0 3 3 2 1 Homodimerisation domain of SGTA TPR_2 PF07719.17 ADV20306.1 - 1.9e-23 80.6 1.3 7.8e-08 31.9 0.0 3.5 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 ADV20306.1 - 9.5e-19 66.8 3.7 7.7e-07 28.7 0.1 3.6 2 1 1 3 3 3 3 TPR repeat TPR_8 PF13181.6 ADV20306.1 - 2.1e-18 64.9 1.7 4.3e-06 26.5 0.0 4.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 ADV20306.1 - 2.6e-11 42.7 0.2 6.3e-06 25.9 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 ADV20306.1 - 5.8e-11 42.3 0.9 0.00011 22.7 0.0 4.2 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 ADV20306.1 - 1.6e-09 38.3 7.7 0.00047 20.7 1.5 2.9 2 1 2 4 4 3 3 Tetratricopeptide repeat TPR_19 PF14559.6 ADV20306.1 - 6.8e-09 36.1 1.2 7.1e-07 29.7 0.1 3.0 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 ADV20306.1 - 2.3e-08 33.9 1.0 0.0063 16.8 0.0 4.3 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 ADV20306.1 - 4.1e-07 30.2 1.9 0.026 14.8 0.6 3.1 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 ADV20306.1 - 1.3e-05 24.9 3.9 0.17 11.8 0.1 3.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_15 PF13429.6 ADV20306.1 - 2.3e-05 23.8 0.2 4.8e-05 22.7 0.2 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ADV20306.1 - 0.0004 20.4 0.1 0.014 15.5 0.0 2.6 2 0 0 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat TPR_9 PF13371.6 ADV20306.1 - 0.00043 20.4 0.0 0.0025 17.9 0.0 2.2 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 ADV20306.1 - 0.0014 19.1 2.7 1 10.1 0.0 3.9 4 0 0 4 4 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ADV20306.1 - 0.0018 18.4 0.7 0.048 13.9 0.1 2.3 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 BTAD PF03704.17 ADV20306.1 - 0.012 16.0 0.1 0.041 14.3 0.1 1.8 1 1 0 1 1 1 0 Bacterial transcriptional activator domain MIT PF04212.18 ADV20306.1 - 0.018 15.1 4.4 3.5 7.8 0.0 3.6 3 1 0 3 3 3 0 MIT (microtubule interacting and transport) domain STI1 PF17830.1 ADV20306.1 - 0.04 13.8 11.3 0.44 10.5 6.6 3.4 2 1 0 3 3 2 0 STI1 domain NARP1 PF12569.8 ADV20306.1 - 0.084 11.8 0.2 0.37 9.6 0.1 1.8 1 1 2 3 3 3 0 NMDA receptor-regulated protein 1 RNase_T PF00929.24 ADV20307.1 - 8.5e-28 98.0 0.0 1e-27 97.7 0.0 1.0 1 0 0 1 1 1 1 Exonuclease F-box_5 PF18511.1 ADV20307.1 - 0.0035 16.9 0.1 2.8 7.6 0.0 2.4 2 0 0 2 2 2 2 F-box Peptidase_M28 PF04389.17 ADV20308.1 - 2.9e-25 89.1 0.0 4.7e-25 88.4 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 ADV20308.1 - 0.00021 21.0 0.0 0.00084 19.1 0.0 1.9 1 1 1 2 2 2 1 Peptidase family M20/M25/M40 RabGAP-TBC PF00566.18 ADV20309.1 - 2.8e-13 50.0 0.5 4.4e-12 46.1 0.4 2.2 2 0 0 2 2 2 1 Rab-GTPase-TBC domain MNE1 PF13762.6 ADV20309.1 - 0.02 14.9 0.2 0.034 14.1 0.2 1.3 1 0 0 1 1 1 0 Mitochondrial splicing apparatus component zf-ZPR1 PF03367.13 ADV20310.1 - 8.6e-106 350.7 0.0 7.8e-54 181.8 0.0 2.5 2 1 0 2 2 2 2 ZPR1 zinc-finger domain HypA PF01155.19 ADV20310.1 - 3.4e-05 23.8 0.9 0.12 12.4 0.1 2.3 2 0 0 2 2 2 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Zn-ribbon_8 PF09723.10 ADV20310.1 - 0.0083 16.2 5.8 1.9 8.7 0.1 3.4 3 1 0 3 3 3 2 Zinc ribbon domain DiS_P_DiS PF06750.13 ADV20310.1 - 0.091 12.9 3.4 2.8 8.1 0.1 2.8 2 1 0 2 2 2 0 Bacterial Peptidase A24 N-terminal domain Cytochrome_C7 PF14522.6 ADV20310.1 - 0.11 12.6 1.7 1.1 9.3 0.5 2.5 2 1 0 2 2 2 0 Cytochrome c7 and related cytochrome c zf-ribbon_3 PF13248.6 ADV20310.1 - 0.14 11.6 4.9 11 5.5 0.0 3.4 3 0 0 3 3 3 0 zinc-ribbon domain OrfB_Zn_ribbon PF07282.11 ADV20310.1 - 0.22 11.5 5.9 16 5.5 0.0 3.5 2 1 1 3 3 3 0 Putative transposase DNA-binding domain DZR PF12773.7 ADV20310.1 - 0.26 11.3 6.6 0.43 10.6 0.2 2.9 2 1 0 2 2 2 0 Double zinc ribbon zinc-ribbons_6 PF07191.12 ADV20310.1 - 0.43 10.6 2.6 4.8 7.2 0.1 2.5 2 1 0 2 2 2 0 zinc-ribbons UPF0547 PF10571.9 ADV20310.1 - 1.1 9.4 5.6 8.7 6.5 0.1 3.2 3 0 0 3 3 3 0 Uncharacterised protein family UPF0547 G-patch PF01585.23 ADV20311.1 - 4.5e-05 23.3 0.3 0.0001 22.1 0.3 1.6 1 0 0 1 1 1 1 G-patch domain NINJA_B PF16136.5 ADV20311.1 - 0.0029 18.0 0.5 0.0029 18.0 0.5 2.6 3 0 0 3 3 3 1 Putative nuclear localisation signal RRM_1 PF00076.22 ADV20311.1 - 0.16 11.8 0.0 0.38 10.6 0.0 1.7 1 1 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Flavoprotein PF02441.19 ADV20312.1 - 1.2e-24 86.9 0.0 6.7e-24 84.4 0.0 1.9 1 1 0 1 1 1 1 Flavoprotein SNF2_N PF00176.23 ADV20313.1 - 1.7e-69 234.2 0.0 2.5e-69 233.7 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain HIRAN PF08797.11 ADV20313.1 - 7.2e-28 96.4 0.0 2e-27 94.9 0.0 1.8 1 1 0 1 1 1 1 HIRAN domain Helicase_C PF00271.31 ADV20313.1 - 1.6e-16 60.6 0.1 9.6e-16 58.1 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ADV20313.1 - 1.3e-08 35.0 0.0 3.7e-07 30.3 0.0 2.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit zf-C3HC4 PF00097.25 ADV20313.1 - 2e-05 24.4 11.3 3.7e-05 23.5 11.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ADV20313.1 - 0.008 16.5 10.8 0.017 15.4 10.8 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 ADV20313.1 - 0.0087 15.9 7.5 0.016 15.1 7.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ADV20313.1 - 0.053 13.4 10.4 0.11 12.3 10.4 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ADV20313.1 - 0.15 12.2 7.1 0.35 11.0 7.1 1.6 1 0 0 1 1 1 0 RING-type zinc-finger Prok-RING_4 PF14447.6 ADV20313.1 - 0.15 11.9 9.5 0.38 10.7 9.5 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 ADV20313.1 - 1.6 8.7 9.0 3.3 7.8 9.0 1.5 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_4 PF15227.6 ADV20313.1 - 3 8.1 12.0 6.3 7.0 12.0 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING DUF3246 PF11596.8 ADV20313.1 - 3.3 7.1 5.8 8.6 5.7 5.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) RPA_interact_C PF14768.6 ADV20314.1 - 0.046 14.3 0.8 0.086 13.4 0.1 1.8 2 0 0 2 2 2 0 Replication protein A interacting C-terminal SIT PF15330.6 ADV20315.1 - 0.17 12.4 0.1 0.28 11.6 0.1 1.4 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT EphA2_TM PF14575.6 ADV20315.1 - 0.22 12.4 0.8 0.38 11.7 0.7 1.7 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Aha1_N PF09229.11 ADV20316.1 - 1.5e-32 112.7 0.0 3.3e-32 111.6 0.0 1.6 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.11 ADV20316.1 - 3.1e-16 59.7 0.0 5.7e-16 58.9 0.0 1.4 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Polyketide_cyc2 PF10604.9 ADV20316.1 - 4e-06 27.2 0.1 1.4e-05 25.4 0.0 1.8 2 0 0 2 2 2 1 Polyketide cyclase / dehydrase and lipid transport Ribosomal_60s PF00428.19 ADV20316.1 - 0.4 11.3 6.4 1 10.0 6.4 1.7 1 0 0 1 1 1 0 60s Acidic ribosomal protein TFR_dimer PF04253.15 ADV20318.1 - 6e-23 81.2 0.0 1.2e-20 73.8 0.0 2.4 2 0 0 2 2 2 2 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 ADV20318.1 - 1.7e-15 57.3 0.0 7.2e-15 55.2 0.0 1.9 1 1 0 1 1 1 1 Peptidase family M28 PA PF02225.22 ADV20318.1 - 2.9e-12 46.4 0.2 7.8e-12 45.1 0.2 1.6 1 0 0 1 1 1 1 PA domain ORC5_C PF14630.6 ADV20319.1 - 1.1e-47 162.9 0.0 1.6e-47 162.4 0.0 1.2 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus V-SNARE_C PF12352.8 ADV20320.1 - 2.7e-16 59.6 0.1 5.6e-16 58.6 0.1 1.6 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 ADV20320.1 - 0.0045 16.9 0.1 0.025 14.5 0.0 1.9 2 0 0 2 2 2 1 Sec20 Spermine_synth PF01564.17 ADV20321.1 - 0.0056 16.1 0.0 0.019 14.4 0.0 1.8 1 1 0 1 1 1 1 Spermine/spermidine synthase domain Hemerythrin PF01814.23 ADV20322.1 - 1e-13 52.0 2.7 1.4e-13 51.6 2.7 1.2 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain TCTP PF00838.17 ADV20322.1 - 0.0037 17.6 0.2 0.0077 16.6 0.1 1.3 1 1 0 1 1 1 1 Translationally controlled tumour protein Cnl2_NKP2 PF09447.10 ADV20322.1 - 0.044 13.9 0.1 0.12 12.5 0.1 1.8 1 0 0 1 1 1 0 Cnl2/NKP2 family protein Pex24p PF06398.11 ADV20323.1 - 0.2 10.6 12.3 0.38 9.7 12.3 1.5 1 1 0 1 1 1 0 Integral peroxisomal membrane peroxin P16-Arc PF04699.14 ADV20324.1 - 5.3e-48 163.3 0.0 5.9e-48 163.1 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) Utp12 PF04003.12 ADV20324.1 - 0.099 13.0 0.0 0.14 12.5 0.0 1.2 1 0 0 1 1 1 0 Dip2/Utp12 Family TPR_1 PF00515.28 ADV20325.1 - 2.9e-33 112.3 6.0 4.6e-07 29.4 0.0 7.9 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_2 PF07719.17 ADV20325.1 - 1.5e-30 102.8 10.9 1.1e-05 25.1 0.0 8.6 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_8 PF13181.6 ADV20325.1 - 2.6e-22 77.1 0.2 0.0078 16.4 0.0 7.9 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_19 PF14559.6 ADV20325.1 - 1.2e-20 73.7 0.0 2.5e-07 31.1 0.1 6.2 5 1 1 6 6 5 4 Tetratricopeptide repeat TPR_11 PF13414.6 ADV20325.1 - 1.8e-17 62.8 0.1 0.00034 20.2 0.1 6.8 5 2 1 6 6 6 5 TPR repeat TPR_16 PF13432.6 ADV20325.1 - 7.1e-16 58.6 11.8 2.4e-05 24.9 0.1 6.4 6 1 1 7 7 7 3 Tetratricopeptide repeat TPR_14 PF13428.6 ADV20325.1 - 2.4e-14 52.8 12.7 0.028 15.2 0.0 7.8 4 1 4 8 8 7 4 Tetratricopeptide repeat ANAPC3 PF12895.7 ADV20325.1 - 2.2e-13 50.2 19.4 0.00047 20.3 1.4 6.8 3 2 5 8 8 8 5 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 ADV20325.1 - 1.5e-12 47.0 0.5 0.11 13.0 0.0 8.5 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_12 PF13424.6 ADV20325.1 - 6.6e-11 42.3 8.1 0.026 14.8 0.4 6.7 6 1 1 7 7 6 3 Tetratricopeptide repeat TPR_15 PF13429.6 ADV20325.1 - 1.7e-08 34.1 0.9 0.0008 18.7 0.1 3.8 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 ADV20325.1 - 1e-07 32.1 15.5 17 6.3 0.0 9.2 10 0 0 10 10 9 0 Tetratricopeptide repeat Sel1 PF08238.12 ADV20325.1 - 0.00012 22.6 0.2 24 5.8 0.0 4.6 4 0 0 4 4 4 0 Sel1 repeat TPR_9 PF13371.6 ADV20325.1 - 0.00049 20.2 7.8 0.064 13.4 0.1 3.9 3 1 1 4 4 4 2 Tetratricopeptide repeat BTAD PF03704.17 ADV20325.1 - 0.0064 16.9 3.9 0.13 12.7 0.1 3.4 2 1 1 3 3 2 1 Bacterial transcriptional activator domain TPR_7 PF13176.6 ADV20325.1 - 0.015 15.3 16.0 4.6 7.5 0.0 6.6 8 0 0 8 8 5 0 Tetratricopeptide repeat FAT PF02259.23 ADV20325.1 - 0.041 13.1 1.2 2 7.6 0.8 3.1 2 1 1 3 3 3 0 FAT domain PknG_TPR PF16918.5 ADV20325.1 - 0.065 11.9 0.4 0.91 8.2 0.0 2.2 2 0 0 2 2 2 0 Protein kinase G tetratricopeptide repeat Sec16_C PF12931.7 ADV20325.1 - 0.099 12.3 0.0 1.2 8.7 0.0 2.2 2 0 0 2 2 2 0 Sec23-binding domain of Sec16 DUF3519 PF12033.8 ADV20325.1 - 0.2 12.0 0.8 0.45 10.9 0.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3519) TPR_21 PF09976.9 ADV20325.1 - 0.52 10.0 2.4 0.76 9.5 0.2 2.4 3 0 0 3 3 3 0 Tetratricopeptide repeat-like domain Raptor_N PF14538.6 ADV20326.1 - 1.5e-12 47.7 0.0 6.9e-12 45.5 0.0 2.1 1 1 0 1 1 1 1 Raptor N-terminal CASPase like domain BNR_2 PF13088.6 ADV20326.1 - 0.059 12.7 1.1 0.1 11.9 1.1 1.3 1 0 0 1 1 1 0 BNR repeat-like domain DnaJ-X PF14308.6 ADV20327.1 - 2.6e-58 197.0 0.8 2.6e-58 197.0 0.8 2.2 2 1 0 2 2 2 1 X-domain of DnaJ-containing DnaJ PF00226.31 ADV20327.1 - 1.2e-24 86.2 2.0 3.5e-24 84.7 2.0 1.9 1 0 0 1 1 1 1 DnaJ domain DUF1737 PF08410.10 ADV20327.1 - 0.086 12.7 0.1 5.5 6.9 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1737) Vma12 PF11712.8 ADV20327.1 - 2.8 8.0 8.8 2.2 8.4 4.8 2.8 2 1 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase SRP-alpha_N PF04086.13 ADV20327.1 - 4.3 7.2 14.2 0.25 11.3 6.7 2.0 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal LTXXQ PF07813.12 ADV20327.1 - 6 7.6 15.0 0.22 12.3 0.5 3.6 3 0 0 3 3 3 0 LTXXQ motif family protein DUF2680 PF10925.8 ADV20327.1 - 9.1 6.4 9.9 1.6 8.8 5.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2680) XPG_N PF00752.17 ADV20328.1 - 3e-30 104.7 0.0 6.6e-30 103.6 0.0 1.6 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 ADV20328.1 - 1.4e-24 86.2 0.0 3.6e-24 84.9 0.0 1.8 1 0 0 1 1 1 1 XPG I-region XPG_I_2 PF12813.7 ADV20328.1 - 0.0011 18.5 0.1 0.0011 18.5 0.1 1.8 2 0 0 2 2 2 1 XPG domain containing Beta-lactamase PF00144.24 ADV20328.1 - 0.031 13.5 0.4 0.078 12.2 0.0 1.7 2 0 0 2 2 2 0 Beta-lactamase UIM PF02809.20 ADV20328.1 - 1.9 8.6 5.9 1.8 8.7 0.3 3.5 2 0 0 2 2 2 0 Ubiquitin interaction motif API5 PF05918.11 ADV20328.1 - 6.4 5.5 9.2 11 4.6 9.2 1.3 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) Myb_DNA-bind_7 PF15963.5 ADV20329.1 - 2.1e-17 62.8 0.1 2.1e-17 62.8 0.1 2.3 2 0 0 2 2 2 1 Myb DNA-binding like Myb_DNA-binding PF00249.31 ADV20329.1 - 0.012 15.8 0.1 0.035 14.3 0.0 1.8 2 0 0 2 2 2 0 Myb-like DNA-binding domain rRNA_processing PF08524.11 ADV20329.1 - 0.016 15.3 4.0 0.016 15.3 4.0 3.0 3 0 0 3 3 3 0 rRNA processing Chromo PF00385.24 ADV20330.1 - 2.2e-10 40.2 0.9 2.2e-10 40.2 0.9 4.1 3 2 1 4 4 4 1 Chromo (CHRromatin Organisation MOdifier) domain DUF3316 PF11777.8 ADV20330.1 - 0.075 13.1 0.0 0.16 12.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3316) HSP70 PF00012.20 ADV20331.1 - 8.4e-232 770.6 7.2 9.4e-232 770.5 7.2 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 ADV20331.1 - 3.5e-18 65.5 0.9 4.7e-17 61.8 0.4 2.2 2 0 0 2 2 2 1 MreB/Mbl protein StbA PF06406.11 ADV20331.1 - 0.003 16.8 0.0 0.0057 15.9 0.0 1.4 1 0 0 1 1 1 1 StbA protein DDR PF08841.10 ADV20331.1 - 0.0081 15.2 0.1 0.079 11.9 0.1 2.3 2 0 0 2 2 2 1 Diol dehydratase reactivase ATPase-like domain BcrAD_BadFG PF01869.20 ADV20331.1 - 0.012 15.1 0.1 4.5 6.7 0.0 2.9 2 1 1 3 3 3 0 BadF/BadG/BcrA/BcrD ATPase family Hydantoinase_A PF01968.18 ADV20331.1 - 0.019 14.2 0.2 0.019 14.2 0.2 1.7 2 0 0 2 2 2 0 Hydantoinase/oxoprolinase FGGY_C PF02782.16 ADV20331.1 - 0.021 14.6 0.0 0.054 13.2 0.0 1.8 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain ARID PF01388.21 ADV20332.1 - 0.019 15.6 0.0 0.046 14.4 0.0 1.7 1 0 0 1 1 1 0 ARID/BRIGHT DNA binding domain ApoO PF09769.9 ADV20333.1 - 9.5e-27 93.5 0.1 3.1e-26 91.9 0.0 1.8 2 0 0 2 2 2 1 Apolipoprotein O ATP-synt_B PF00430.18 ADV20333.1 - 0.55 10.3 2.7 0.9 9.6 2.7 1.2 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) Inositol_P PF00459.25 ADV20334.1 - 1.8e-44 152.3 0.1 1.7e-43 149.1 0.1 1.9 1 1 0 1 1 1 1 Inositol monophosphatase family Bromodomain PF00439.25 ADV20335.1 - 3.6e-26 91.0 0.2 7.4e-26 90.0 0.2 1.5 1 0 0 1 1 1 1 Bromodomain Acetyltransf_1 PF00583.25 ADV20335.1 - 1.8e-08 34.6 0.4 5.1e-08 33.2 0.1 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ADV20335.1 - 2.9e-08 33.7 0.0 6.4e-08 32.6 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ADV20335.1 - 3.8e-05 24.0 0.1 7.6e-05 23.1 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ADV20335.1 - 0.0011 18.9 0.0 0.0023 17.9 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein Ldt_C PF17969.1 ADV20335.1 - 0.032 15.0 0.2 1.9 9.3 0.1 2.8 2 0 0 2 2 2 0 L,D-transpeptidase C-terminal domain CRC_subunit PF08624.10 ADV20336.1 - 3.3e-41 140.9 0.0 5.5e-41 140.2 0.0 1.3 1 0 0 1 1 1 1 Chromatin remodelling complex Rsc7/Swp82 subunit Shugoshin_C PF07557.11 ADV20336.1 - 0.012 15.4 0.4 0.012 15.4 0.4 2.7 2 0 0 2 2 2 0 Shugoshin C terminus ubiquitin PF00240.23 ADV20337.1 - 3.6e-34 116.4 0.6 5e-34 115.9 0.6 1.2 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_L40e PF01020.17 ADV20337.1 - 5.6e-30 103.0 9.3 8.7e-30 102.4 9.3 1.3 1 0 0 1 1 1 1 Ribosomal L40e family Rad60-SLD PF11976.8 ADV20337.1 - 3.1e-16 59.0 0.7 3.1e-16 59.0 0.7 1.6 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 ADV20337.1 - 2e-05 24.9 0.1 7.5e-05 23.1 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain Ubiquitin_5 PF18037.1 ADV20337.1 - 0.0036 17.6 0.0 0.0056 17.0 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 ADV20337.1 - 0.0039 17.1 0.0 0.0052 16.7 0.0 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 ADV20337.1 - 0.0069 16.5 0.0 0.014 15.5 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 ADV20337.1 - 0.014 15.4 1.0 4.3 7.5 0.2 2.2 2 0 0 2 2 2 0 Ubiquitin-like domain DUF2407 PF10302.9 ADV20337.1 - 0.026 15.1 0.1 0.035 14.7 0.1 1.3 1 1 0 1 1 1 0 DUF2407 ubiquitin-like domain Sde2_N_Ubi PF13019.6 ADV20337.1 - 0.079 12.8 0.0 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 Silencing defective 2 N-terminal ubiquitin domain Med6 PF04934.14 ADV20338.1 - 3.6e-29 101.2 0.0 5e-29 100.8 0.0 1.2 1 0 0 1 1 1 1 MED6 mediator sub complex component Hexapep PF00132.24 ADV20339.1 - 9.7e-08 31.5 14.2 7.3e-05 22.3 2.6 4.7 3 1 2 5 5 5 4 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 ADV20339.1 - 0.01 15.6 10.4 0.34 10.7 0.8 3.7 4 0 0 4 4 4 0 Hexapeptide repeat of succinyl-transferase Fucokinase PF07959.12 ADV20339.1 - 0.043 12.7 0.0 0.075 12.0 0.0 1.3 1 0 0 1 1 1 0 L-fucokinase Peptidase_M22 PF00814.25 ADV20340.1 - 4.9e-86 288.8 0.0 6e-86 288.5 0.0 1.0 1 0 0 1 1 1 1 Glycoprotease family Carbam_trans_N PF02543.15 ADV20340.1 - 0.013 15.2 0.0 0.33 10.6 0.0 2.1 2 0 0 2 2 2 0 Carbamoyltransferase N-terminus MBOAT PF03062.19 ADV20341.1 - 6.5e-46 157.3 1.0 1.1e-45 156.5 1.0 1.3 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family WCOR413 PF05562.11 ADV20341.1 - 0.5 10.3 4.9 0.28 11.1 0.6 2.3 2 0 0 2 2 2 0 Cold acclimation protein WCOR413 ZapB PF06005.12 ADV20342.1 - 0.0016 18.8 0.9 0.0016 18.8 0.9 3.5 2 1 0 2 2 1 1 Cell division protein ZapB Filament PF00038.21 ADV20342.1 - 0.0084 15.7 12.8 0.0084 15.7 12.8 2.1 1 1 1 2 2 2 1 Intermediate filament protein TPR_MLP1_2 PF07926.12 ADV20342.1 - 0.015 15.4 18.8 0.085 12.9 11.2 2.6 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein APG6_N PF17675.1 ADV20342.1 - 0.091 13.3 16.8 0.24 11.9 5.4 2.8 2 0 0 2 2 2 0 Apg6 coiled-coil region TMF_DNA_bd PF12329.8 ADV20342.1 - 0.22 11.6 14.3 4 7.5 0.5 3.7 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding CdvA PF18822.1 ADV20342.1 - 0.34 10.7 13.1 0.059 13.2 2.4 2.9 2 1 1 3 3 3 0 CdvA-like coiled-coil domain SYCE1 PF15233.6 ADV20342.1 - 0.56 10.3 15.4 0.42 10.7 12.7 2.1 1 1 0 1 1 1 0 Synaptonemal complex central element protein 1 DUF5082 PF16888.5 ADV20342.1 - 0.81 10.0 12.1 3.4 8.0 0.2 2.8 1 1 1 3 3 3 0 Domain of unknown function (DUF5082) Fez1 PF06818.15 ADV20342.1 - 1.3 9.5 17.7 3.4 8.1 10.3 2.4 1 1 1 2 2 2 0 Fez1 DivIC PF04977.15 ADV20342.1 - 1.5 8.6 17.0 0.33 10.7 0.7 3.7 2 1 0 3 3 3 0 Septum formation initiator KASH_CCD PF14662.6 ADV20342.1 - 1.9 8.3 17.9 2.6 7.8 5.7 2.7 1 1 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH ERM PF00769.19 ADV20342.1 - 2.4 7.9 19.4 0.42 10.4 15.3 1.8 2 0 0 2 2 1 0 Ezrin/radixin/moesin family Snapin_Pallidin PF14712.6 ADV20342.1 - 3.3 8.2 11.5 5.4 7.5 5.9 3.0 2 1 0 2 2 2 0 Snapin/Pallidin Ax_dynein_light PF10211.9 ADV20342.1 - 3.4 7.6 17.9 0.5 10.3 1.9 3.2 1 1 2 3 3 3 0 Axonemal dynein light chain DUF745 PF05335.13 ADV20342.1 - 6.4 6.5 11.3 1.6 8.4 4.5 2.5 1 1 0 2 2 2 0 Protein of unknown function (DUF745) YabA PF06156.13 ADV20342.1 - 6.8 7.4 15.5 17 6.1 4.7 3.4 1 1 1 3 3 3 0 Initiation control protein YabA Prefoldin_2 PF01920.20 ADV20342.1 - 7.9 6.5 13.3 1.1 9.2 0.2 3.5 2 1 0 2 2 2 0 Prefoldin subunit DUF2570 PF10828.8 ADV20342.1 - 9.5 6.1 9.3 16 5.4 0.4 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF2570) Vps53_N PF04100.12 ADV20343.1 - 6.1e-74 249.3 0.1 1.3e-73 248.2 0.1 1.5 1 0 0 1 1 1 1 Vps53-like, N-terminal Sec6 PF06046.13 ADV20343.1 - 1.8e-08 33.3 0.0 3e-08 32.5 0.0 1.3 1 0 0 1 1 1 1 Exocyst complex component Sec6 VPS53_C PF16854.5 ADV20343.1 - 5.3e-07 29.7 0.0 1.9e-05 24.6 0.0 2.5 1 1 1 2 2 2 1 Vacuolar protein sorting-associated protein 53 C-terminus RINT1_TIP1 PF04437.13 ADV20343.1 - 0.00015 20.8 0.5 0.00039 19.4 0.0 1.8 2 1 0 2 2 2 1 RINT-1 / TIP-1 family Spc7 PF08317.11 ADV20343.1 - 0.01 14.7 5.0 0.02 13.8 5.0 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF2451 PF10474.9 ADV20343.1 - 0.038 13.8 1.0 0.053 13.3 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function C-terminus (DUF2451) GAS PF13851.6 ADV20343.1 - 0.056 12.8 4.7 0.11 11.8 4.7 1.5 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Mer2 PF09074.10 ADV20343.1 - 0.094 12.5 3.2 0.2 11.4 1.4 2.4 2 0 0 2 2 2 0 Mer2 ECH_1 PF00378.20 ADV20344.1 - 2e-55 187.8 0.0 2.4e-55 187.6 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ADV20344.1 - 6e-35 121.3 0.0 2.8e-31 109.3 0.0 2.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase Cellulase PF00150.18 ADV20345.1 - 1.7e-09 37.5 4.5 2.7e-09 36.9 4.5 1.3 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Senescence PF06911.12 ADV20346.1 - 5.9e-30 104.9 9.7 1.3e-28 100.5 9.7 2.3 1 1 0 1 1 1 1 Senescence-associated protein SIR2 PF02146.17 ADV20347.1 - 2.4e-34 118.8 0.0 4.4e-34 117.9 0.0 1.4 1 1 0 1 1 1 1 Sir2 family Zn-ribbon_8 PF09723.10 ADV20347.1 - 0.1 12.7 2.4 0.19 11.9 2.4 1.5 1 0 0 1 1 1 0 Zinc ribbon domain SUZ PF12752.7 ADV20348.1 - 1.6e-11 44.8 1.7 1.6e-11 44.8 1.7 4.5 4 1 0 4 4 4 1 SUZ domain R3H PF01424.22 ADV20348.1 - 0.061 13.3 0.0 0.17 11.9 0.0 1.8 1 0 0 1 1 1 0 R3H domain ABC_tran PF00005.27 ADV20349.1 - 0.00028 21.4 0.1 0.00065 20.2 0.1 1.5 1 0 0 1 1 1 1 ABC transporter MobB PF03205.14 ADV20349.1 - 0.0028 17.5 0.8 0.13 12.1 0.6 2.4 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_33 PF13671.6 ADV20349.1 - 0.018 15.2 0.0 0.052 13.7 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 ADV20349.1 - 0.022 14.5 0.7 0.12 12.1 0.3 2.1 2 0 0 2 2 2 0 P-loop containing region of AAA domain ATPase PF06745.13 ADV20349.1 - 0.026 13.9 0.0 0.085 12.2 0.0 1.9 2 0 0 2 2 2 0 KaiC AAA_25 PF13481.6 ADV20349.1 - 0.028 14.0 0.2 0.46 10.0 0.0 2.4 2 1 0 2 2 2 0 AAA domain AAA_16 PF13191.6 ADV20349.1 - 0.1 12.9 0.0 0.18 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain RecA PF00154.21 ADV20349.1 - 0.12 11.8 0.1 6.4 6.2 0.0 2.3 2 1 0 2 2 2 0 recA bacterial DNA recombination protein AAA_22 PF13401.6 ADV20349.1 - 0.13 12.5 0.0 0.27 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 ADV20349.1 - 0.16 11.9 0.6 0.48 10.3 0.1 2.0 2 0 0 2 2 2 0 NACHT domain cobW PF02492.19 ADV20349.1 - 0.38 10.3 1.3 0.54 9.8 0.6 1.6 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Nas2_N PF18265.1 ADV20350.1 - 9.4e-16 57.5 0.0 1.3e-15 57.0 0.0 1.2 1 0 0 1 1 1 1 Nas2 N_terminal domain GRASP55_65 PF04495.14 ADV20350.1 - 9.2e-08 32.5 0.0 1.1e-07 32.3 0.0 1.2 1 0 0 1 1 1 1 GRASP55/65 PDZ-like domain PDZ_6 PF17820.1 ADV20350.1 - 1.1e-05 25.1 0.0 1.8e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 ADV20350.1 - 3.9e-05 23.9 0.0 6.2e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 PDZ domain TAP42 PF04177.12 ADV20351.1 - 3.5e-73 246.5 0.1 3.8e-73 246.4 0.1 1.0 1 0 0 1 1 1 1 TAP42-like family Fungal_trans PF04082.18 ADV20352.1 - 0.056 12.5 1.4 0.12 11.4 1.4 1.6 1 1 0 1 1 1 0 Fungal specific transcription factor domain Abhydrolase_1 PF00561.20 ADV20353.1 - 6.8e-06 25.9 0.0 0.00052 19.7 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ADV20353.1 - 0.00041 21.0 1.7 0.00069 20.3 1.6 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ADV20353.1 - 0.0011 18.3 0.0 0.0022 17.3 0.0 1.4 1 1 0 1 1 1 1 Serine aminopeptidase, S33 NDUF_B8 PF05821.11 ADV20354.1 - 7.2e-08 32.5 0.0 1.1e-07 31.9 0.0 1.3 1 1 0 1 1 1 1 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) DASH_Dad2 PF08654.10 ADV20355.1 - 2.6e-14 53.4 0.0 3.8e-14 52.9 0.0 1.1 1 0 0 1 1 1 1 DASH complex subunit Dad2 Turandot PF07240.11 ADV20355.1 - 0.067 13.2 0.0 0.091 12.7 0.0 1.2 1 0 0 1 1 1 0 Stress-inducible humoral factor Turandot DUF4381 PF14316.6 ADV20356.1 - 0.019 15.2 1.3 0.02 15.1 0.3 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) Codanin-1_C PF15296.6 ADV20356.1 - 0.02 15.0 2.8 0.037 14.1 2.1 1.7 2 0 0 2 2 2 0 Codanin-1 C-terminus BatD PF13584.6 ADV20356.1 - 0.045 12.6 0.0 0.048 12.5 0.0 1.1 1 0 0 1 1 1 0 Oxygen tolerance BT1 PF03092.16 ADV20356.1 - 0.18 10.0 0.0 0.17 10.0 0.0 1.1 1 0 0 1 1 1 0 BT1 family Gram_pos_anchor PF00746.21 ADV20356.1 - 0.19 11.7 0.3 0.45 10.5 0.3 1.6 1 0 0 1 1 1 0 LPXTG cell wall anchor motif PIN_4 PF13638.6 ADV20358.1 - 6.6e-24 84.7 0.1 6.6e-24 84.7 0.1 1.9 2 0 0 2 2 2 1 PIN domain EST1_DNA_bind PF10373.9 ADV20358.1 - 2.8e-09 36.9 0.0 6.2e-09 35.7 0.0 1.7 1 1 0 1 1 1 1 Est1 DNA/RNA binding domain PIN_9 PF18477.1 ADV20358.1 - 0.0049 17.2 0.6 0.14 12.5 0.1 2.7 1 1 1 2 2 2 1 PIN like domain Troponin PF00992.20 ADV20358.1 - 1.3 9.4 15.5 0.065 13.5 8.6 2.3 3 0 0 3 3 3 0 Troponin APG6_N PF17675.1 ADV20358.1 - 7.1 7.2 13.8 22 5.5 13.8 1.8 1 0 0 1 1 1 0 Apg6 coiled-coil region CLTH PF10607.9 ADV20359.1 - 2.3e-11 43.8 0.0 4.6e-11 42.8 0.0 1.5 1 1 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain Rer1 PF03248.13 ADV20360.1 - 2.7e-74 248.5 0.0 3.3e-74 248.3 0.0 1.0 1 0 0 1 1 1 1 Rer1 family Wbp11 PF09429.10 ADV20361.1 - 3.8e-17 62.4 18.5 7.3e-17 61.5 18.5 1.5 1 0 0 1 1 1 1 WW domain binding protein 11 NpwBP PF12622.7 ADV20361.1 - 7e-13 49.1 19.7 7e-13 49.1 19.7 4.5 3 1 0 3 3 3 1 mRNA biogenesis factor TRIQK PF15168.6 ADV20361.1 - 4.8 7.1 5.1 10 6.1 5.1 1.6 1 1 0 1 1 1 0 Triple QxxK/R motif-containing protein family APG6_N PF17675.1 ADV20361.1 - 5.3 7.6 15.8 12 6.4 15.8 1.6 1 0 0 1 1 1 0 Apg6 coiled-coil region TMPIT PF07851.13 ADV20361.1 - 6.4 5.9 9.1 9 5.4 9.1 1.1 1 0 0 1 1 1 0 TMPIT-like protein AAA_13 PF13166.6 ADV20361.1 - 7.3 5.1 12.3 9.5 4.7 12.3 1.1 1 0 0 1 1 1 0 AAA domain Ham1p_like PF01725.16 ADV20362.1 - 2.5e-57 193.8 0.0 2.8e-57 193.7 0.0 1.0 1 0 0 1 1 1 1 Ham1 family UPF0183 PF03676.14 ADV20363.1 - 2.3e-30 106.2 0.0 5.5e-18 65.4 0.0 2.1 2 0 0 2 2 2 2 Uncharacterised protein family (UPF0183) DUF3108 PF11306.8 ADV20363.1 - 0.053 13.5 0.2 0.082 12.9 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3108) ECH_2 PF16113.5 ADV20364.1 - 2.9e-90 303.2 0.0 3.7e-90 302.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 ADV20364.1 - 3.1e-23 82.4 0.0 3.5e-22 78.9 0.0 2.4 2 1 0 2 2 2 1 Enoyl-CoA hydratase/isomerase Disulph_isomer PF06491.11 ADV20364.1 - 0.082 13.0 0.0 0.16 12.1 0.0 1.5 1 0 0 1 1 1 0 Disulphide isomerase Peptidase_M20 PF01546.28 ADV20365.1 - 1e-33 116.8 0.0 1.3e-33 116.5 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 ADV20365.1 - 1e-10 41.5 0.0 1.9e-10 40.6 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain MFS_1 PF07690.16 ADV20366.1 - 7.2e-31 107.4 26.2 7.2e-31 107.4 26.2 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily CytochromB561_N PF09786.9 ADV20366.1 - 0.36 9.8 0.3 0.64 8.9 0.3 1.4 1 1 0 1 1 1 0 Cytochrome B561, N terminal GCP_N_terminal PF17681.1 ADV20367.1 - 1.7e-64 218.4 0.0 5.1e-64 216.8 0.0 1.8 2 1 0 2 2 2 1 Gamma tubulin complex component N-terminal LIDHydrolase PF10230.9 ADV20368.1 - 2.7e-35 122.2 0.0 4.3e-34 118.3 0.0 2.0 1 1 0 1 1 1 1 Lipid-droplet associated hydrolase Abhydrolase_6 PF12697.7 ADV20368.1 - 0.0014 19.3 0.8 0.0017 19.0 0.8 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ADV20368.1 - 0.0079 15.5 0.0 0.0097 15.2 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF900 PF05990.12 ADV20368.1 - 0.035 13.6 0.0 0.055 13.0 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Abhydrolase_3 PF07859.13 ADV20368.1 - 0.16 11.8 0.0 0.29 10.9 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold AAA_2 PF07724.14 ADV20369.1 - 4.2e-50 170.2 0.0 2.2e-44 151.6 0.0 2.8 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 ADV20369.1 - 6.1e-31 106.4 2.2 6.1e-31 106.4 2.2 2.7 1 1 1 2 2 2 1 AAA lid domain AAA PF00004.29 ADV20369.1 - 1.4e-25 90.2 0.1 9.9e-14 51.9 0.0 2.8 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 ADV20369.1 - 2.4e-24 85.2 0.1 9.7e-24 83.2 0.1 2.2 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.14 ADV20369.1 - 1.4e-15 57.5 0.0 2.5e-09 37.2 0.0 2.8 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 ADV20369.1 - 1e-10 41.6 0.1 1.8e-07 31.0 0.0 2.7 2 1 0 2 2 2 2 Sigma-54 interaction domain AAA_22 PF13401.6 ADV20369.1 - 1.2e-10 41.8 2.2 0.00067 19.9 0.0 4.6 2 2 1 3 3 3 2 AAA domain Clp_N PF02861.20 ADV20369.1 - 4.7e-10 39.4 2.8 3.2e-08 33.6 1.2 3.1 2 0 0 2 2 2 1 Clp amino terminal domain, pathogenicity island component AAA_16 PF13191.6 ADV20369.1 - 1.3e-09 38.7 14.5 2.1e-06 28.2 0.1 5.3 4 3 0 5 5 3 2 AAA ATPase domain IstB_IS21 PF01695.17 ADV20369.1 - 2.7e-07 30.5 0.0 0.0065 16.2 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein TniB PF05621.11 ADV20369.1 - 9.5e-07 28.4 0.1 0.0063 15.9 0.0 3.6 2 1 0 2 2 2 1 Bacterial TniB protein AAA_24 PF13479.6 ADV20369.1 - 2.7e-06 27.3 0.0 0.0016 18.2 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 ADV20369.1 - 6.7e-06 25.7 0.0 0.057 12.9 0.0 2.9 2 1 0 2 2 2 2 P-loop containing dynein motor region Mg_chelatase PF01078.21 ADV20369.1 - 1.2e-05 24.9 0.0 0.0079 15.6 0.0 2.6 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 ADV20369.1 - 7.3e-05 22.8 0.0 0.22 11.6 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.6 ADV20369.1 - 8.6e-05 22.3 0.1 0.04 13.6 0.0 3.2 3 0 0 3 3 3 1 AAA domain AAA_33 PF13671.6 ADV20369.1 - 8.9e-05 22.7 0.0 0.092 12.9 0.0 2.8 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 ADV20369.1 - 9.8e-05 21.7 0.0 0.02 14.2 0.0 2.9 2 0 0 2 2 2 1 Zeta toxin NACHT PF05729.12 ADV20369.1 - 0.00014 21.8 0.3 0.25 11.3 0.0 2.9 2 1 0 2 2 2 1 NACHT domain RNA_helicase PF00910.22 ADV20369.1 - 0.00027 21.3 0.0 1.3 9.4 0.0 2.8 3 0 0 3 3 2 2 RNA helicase RuvB_N PF05496.12 ADV20369.1 - 0.00046 20.0 5.6 1.1 9.0 0.0 4.8 4 1 0 4 4 4 1 Holliday junction DNA helicase RuvB P-loop domain ATPase_2 PF01637.18 ADV20369.1 - 0.00049 20.1 0.4 3.2 7.6 0.1 4.0 2 1 0 3 3 3 1 ATPase domain predominantly from Archaea ABC_tran PF00005.27 ADV20369.1 - 0.00058 20.4 0.5 0.043 14.3 0.0 3.1 3 0 0 3 3 2 1 ABC transporter TIP49 PF06068.13 ADV20369.1 - 0.00063 19.1 4.0 0.38 9.9 0.0 3.6 4 1 1 5 5 4 2 TIP49 P-loop domain Roc PF08477.13 ADV20369.1 - 0.00096 19.4 0.0 2.4 8.4 0.0 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase PhoH PF02562.16 ADV20369.1 - 0.002 17.6 0.0 0.26 10.7 0.0 2.5 2 0 0 2 2 2 1 PhoH-like protein AAA_19 PF13245.6 ADV20369.1 - 0.0025 18.2 1.8 0.92 9.8 0.0 3.7 2 2 0 2 2 2 1 AAA domain AAA_28 PF13521.6 ADV20369.1 - 0.0047 17.2 2.2 3.9 7.7 0.0 3.7 4 0 0 4 4 2 0 AAA domain TsaE PF02367.17 ADV20369.1 - 0.006 16.6 0.0 5 7.2 0.0 2.6 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_25 PF13481.6 ADV20369.1 - 0.01 15.4 4.9 1.9 8.0 0.0 3.6 3 0 0 3 3 3 0 AAA domain Torsin PF06309.11 ADV20369.1 - 0.012 15.7 0.0 0.16 12.0 0.0 2.4 2 0 0 2 2 2 0 Torsin ResIII PF04851.15 ADV20369.1 - 0.013 15.6 0.0 2 8.4 0.0 3.2 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit BLOC1_2 PF10046.9 ADV20369.1 - 0.02 15.2 0.7 0.068 13.5 0.7 2.0 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 AAA_3 PF07726.11 ADV20369.1 - 0.021 14.7 0.1 20 5.1 0.1 3.3 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.15 ADV20369.1 - 0.022 14.7 0.3 6.3 6.7 0.0 3.7 4 0 0 4 4 3 0 NTPase DUF2075 PF09848.9 ADV20369.1 - 0.032 13.5 0.0 4.4 6.5 0.0 2.5 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) RsgA_GTPase PF03193.16 ADV20369.1 - 0.038 13.9 0.0 11 5.9 0.0 2.5 2 0 0 2 2 2 0 RsgA GTPase AAA_29 PF13555.6 ADV20369.1 - 0.041 13.6 0.1 4.6 7.1 0.1 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_8 PF12780.7 ADV20369.1 - 0.046 13.0 0.1 2.7 7.2 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region D4 AAA_18 PF13238.6 ADV20369.1 - 0.11 13.0 8.8 0.85 10.2 0.0 3.4 4 0 0 4 4 2 0 AAA domain AAA_21 PF13304.6 ADV20369.1 - 0.12 12.1 0.1 4.7 6.9 0.0 3.1 3 0 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system Sigma54_activ_2 PF14532.6 ADV20369.1 - 0.14 12.2 0.0 15 5.7 0.0 2.9 2 0 0 2 2 2 0 Sigma-54 interaction domain SRP54 PF00448.22 ADV20369.1 - 0.15 11.7 0.2 8.4 6.0 0.0 2.8 3 0 0 3 3 2 0 SRP54-type protein, GTPase domain ATPase PF06745.13 ADV20369.1 - 0.17 11.2 3.6 6.1 6.1 0.3 4.0 3 1 1 4 4 4 0 KaiC Fmp27_WPPW PF10359.9 ADV20369.1 - 0.35 9.7 4.6 0.69 8.7 4.6 1.4 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Cob_adeno_trans PF01923.18 ADV20369.1 - 0.46 10.6 4.3 0.29 11.2 0.9 2.4 3 0 0 3 3 1 0 Cobalamin adenosyltransferase DUF4407 PF14362.6 ADV20369.1 - 0.5 9.7 6.2 1.1 8.6 6.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DASH_Spc19 PF08287.11 ADV20369.1 - 1.2 9.0 10.1 0.22 11.4 4.6 2.3 1 1 1 2 2 2 0 Spc19 Laminin_II PF06009.12 ADV20369.1 - 1.9 8.5 7.5 0.15 12.1 0.5 2.5 2 1 1 3 3 2 0 Laminin Domain II AAA_23 PF13476.6 ADV20369.1 - 2.4 8.6 22.8 9.5 6.7 0.0 4.8 5 1 0 5 5 4 0 AAA domain Atg14 PF10186.9 ADV20369.1 - 2.5 7.1 6.2 4.9 6.1 6.2 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Spc7 PF08317.11 ADV20369.1 - 3.7 6.3 15.0 1.6 7.6 10.9 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein TSC22 PF01166.18 ADV20369.1 - 5.2 7.5 6.9 3.7 7.9 0.1 3.2 2 1 1 3 3 2 0 TSC-22/dip/bun family Ras PF00071.22 ADV20370.1 - 2.7e-56 189.7 0.1 3.1e-56 189.4 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ADV20370.1 - 2.9e-20 72.7 0.0 4.5e-20 72.1 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ADV20370.1 - 1.9e-08 33.9 0.0 2.2e-08 33.7 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ADV20370.1 - 2.3e-05 24.0 0.1 4.6e-05 23.0 0.1 1.5 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ADV20370.1 - 0.00086 19.2 0.8 0.85 9.5 0.0 2.3 1 1 1 2 2 2 2 RsgA GTPase MMR_HSR1_Xtn PF16897.5 ADV20370.1 - 0.0028 17.7 0.0 0.0049 16.9 0.0 1.4 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain MMR_HSR1 PF01926.23 ADV20370.1 - 0.0054 16.8 0.0 0.0094 16.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ADV20370.1 - 0.046 13.2 0.1 0.12 11.9 0.1 1.9 1 1 0 1 1 1 0 Ferrous iron transport protein B ATP_bind_1 PF03029.17 ADV20370.1 - 0.3 10.8 2.0 2.3 8.0 0.0 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein Acetyltransf_1 PF00583.25 ADV20371.1 - 0.00043 20.5 0.0 0.00064 19.9 0.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.7 ADV20371.1 - 0.032 14.4 0.0 0.049 13.8 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain zf-CCCH_2 PF14608.6 ADV20372.1 - 1e-11 44.9 32.5 3.9e-05 24.0 1.9 4.4 4 0 0 4 4 4 4 RNA-binding, Nab2-type zinc finger PAM2 PF07145.15 ADV20372.1 - 0.013 15.2 0.0 0.038 13.7 0.0 1.8 1 0 0 1 1 1 0 Ataxin-2 C-terminal region Nab2 PF11517.8 ADV20372.1 - 0.021 15.1 0.0 0.037 14.3 0.0 1.3 1 0 0 1 1 1 0 Nuclear abundant poly(A) RNA-bind protein 2 (Nab2) Fungal_trans PF04082.18 ADV20373.1 - 1.2e-10 40.9 0.7 2.1e-10 40.1 0.1 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ADV20373.1 - 9.5e-08 32.0 8.5 1.6e-07 31.4 8.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ATP-synt_C PF00137.21 ADV20375.1 - 2.2e-31 108.0 31.8 1.7e-18 66.7 14.4 2.2 2 0 0 2 2 2 2 ATP synthase subunit C Sacchrp_dh_C PF16653.5 ADV20376.1 - 4.9e-69 233.4 0.0 7.7e-69 232.7 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase C-terminal domain Sacchrp_dh_NADP PF03435.18 ADV20376.1 - 5.7e-16 59.0 0.7 9e-16 58.3 0.0 1.7 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain AlaDh_PNT_N PF05222.15 ADV20376.1 - 5.1e-13 49.5 0.0 1.5e-12 48.0 0.0 1.8 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain AlaDh_PNT_C PF01262.21 ADV20376.1 - 2.1e-06 27.2 0.1 0.00063 19.1 0.0 2.8 3 0 0 3 3 3 2 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_10 PF13460.6 ADV20376.1 - 0.00064 19.7 0.3 0.0015 18.5 0.1 1.7 2 0 0 2 2 2 1 NAD(P)H-binding DcpS_C PF11969.8 ADV20377.1 - 6.6e-06 26.6 0.0 1.5e-05 25.4 0.0 1.6 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding Pex14_N PF04695.13 ADV20377.1 - 3 8.5 11.2 3.1 8.4 8.7 2.1 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Glyco_hydro_cc PF11790.8 ADV20378.1 - 5.5e-44 150.5 0.6 1.7e-43 148.9 0.0 1.8 2 0 0 2 2 2 1 Glycosyl hydrolase catalytic core RraA-like PF03737.15 ADV20379.1 - 4.2e-29 101.6 0.0 5.7e-29 101.2 0.0 1.2 1 0 0 1 1 1 1 Aldolase/RraA Sec15 PF04091.12 ADV20380.1 - 9.5e-94 314.3 0.6 1.7e-93 313.5 0.6 1.4 1 0 0 1 1 1 1 Exocyst complex subunit Sec15-like Sec8_exocyst PF04048.14 ADV20380.1 - 7.2e-05 22.7 2.6 7.9e-05 22.6 0.3 2.3 3 0 0 3 3 3 1 Sec8 exocyst complex component specific domain COG2 PF06148.11 ADV20380.1 - 0.0042 17.2 1.2 0.0042 17.2 1.2 2.3 3 0 0 3 3 3 1 COG (conserved oligomeric Golgi) complex component, COG2 Vps51 PF08700.11 ADV20380.1 - 0.013 15.6 0.6 0.055 13.5 0.0 2.5 2 0 0 2 2 2 0 Vps51/Vps67 COG5 PF10392.9 ADV20380.1 - 0.31 11.2 6.7 0.036 14.3 1.1 2.5 3 0 0 3 3 3 0 Golgi transport complex subunit 5 NAD_binding_10 PF13460.6 ADV20381.1 - 2.3e-12 47.2 0.0 3.5e-12 46.6 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 ADV20381.1 - 2.7e-09 36.4 0.0 0.00071 18.7 0.0 2.1 1 1 1 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 ADV20381.1 - 2.9e-07 30.2 0.0 2.3e-06 27.2 0.0 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 ADV20381.1 - 8.3e-06 25.1 0.0 1.8e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 RmlD substrate binding domain Sacchrp_dh_NADP PF03435.18 ADV20381.1 - 0.0014 18.9 0.0 0.002 18.4 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 ADV20381.1 - 0.01 15.9 0.0 0.018 15.1 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase KR PF08659.10 ADV20381.1 - 0.037 13.9 0.0 0.058 13.3 0.0 1.2 1 0 0 1 1 1 0 KR domain Pyr_redox PF00070.27 ADV20381.1 - 0.041 14.4 0.0 0.17 12.5 0.0 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_4 PF07993.12 ADV20381.1 - 0.054 12.7 0.0 0.67 9.1 0.0 2.1 2 0 0 2 2 2 0 Male sterility protein K_oxygenase PF13434.6 ADV20381.1 - 0.085 12.0 0.0 0.12 11.5 0.0 1.1 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Semialdhyde_dhC PF02774.18 ADV20382.1 - 9.8e-41 139.8 0.0 1.3e-40 139.4 0.0 1.2 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain Semialdhyde_dh PF01118.24 ADV20382.1 - 2.5e-26 92.5 0.0 4e-26 91.8 0.0 1.3 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain DXP_reductoisom PF02670.16 ADV20382.1 - 0.013 16.2 0.2 0.044 14.5 0.0 1.9 2 0 0 2 2 2 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase DapB_N PF01113.20 ADV20382.1 - 0.019 15.1 0.0 0.047 13.8 0.0 1.7 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus Gp_dh_C PF02800.20 ADV20382.1 - 0.046 13.3 0.0 0.12 12.0 0.0 1.6 1 0 0 1 1 1 0 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Sacchrp_dh_NADP PF03435.18 ADV20382.1 - 0.1 12.9 0.0 0.19 12.0 0.0 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain ORC_WH_C PF18137.1 ADV20383.1 - 2.1e-16 60.3 2.3 2.1e-16 60.3 2.3 2.0 2 1 0 2 2 2 1 Origin recognition complex winged helix C-terminal InvH PF04741.12 ADV20383.1 - 0.067 13.1 0.1 0.13 12.2 0.1 1.4 1 0 0 1 1 1 0 InvH outer membrane lipoprotein BAR PF03114.18 ADV20384.1 - 1.6e-41 142.5 1.1 2.4e-41 142.0 1.1 1.2 1 0 0 1 1 1 1 BAR domain SH3_1 PF00018.28 ADV20384.1 - 3.2e-14 52.3 0.1 5.2e-14 51.6 0.1 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ADV20384.1 - 1.4e-13 50.4 0.1 2.3e-13 49.7 0.1 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 ADV20384.1 - 4.4e-10 39.1 0.0 7.2e-10 38.4 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain CBS PF00571.28 ADV20385.1 - 1.6e-22 79.7 2.8 1.6e-09 38.0 0.1 4.6 4 1 0 4 4 4 4 CBS domain MRP-S28 PF10213.9 ADV20386.1 - 0.091 13.2 0.0 0.16 12.4 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal subunit protein IPPT PF01715.17 ADV20387.1 - 4.9e-43 147.6 0.0 1.6e-25 90.3 0.0 2.3 2 0 0 2 2 2 2 IPP transferase DUF87 PF01935.17 ADV20387.1 - 0.0057 16.8 0.3 0.044 13.9 0.0 2.5 4 0 0 4 4 4 1 Helicase HerA, central domain IstB_IS21 PF01695.17 ADV20387.1 - 0.011 15.5 0.0 0.025 14.3 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_16 PF13191.6 ADV20387.1 - 0.011 16.1 0.0 0.037 14.4 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 ADV20387.1 - 0.012 15.8 0.0 0.054 13.8 0.0 2.1 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 ADV20387.1 - 0.028 15.0 0.1 0.16 12.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain PhoH PF02562.16 ADV20387.1 - 0.099 12.1 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein CbiA PF01656.23 ADV20387.1 - 0.12 12.4 0.9 0.17 12.0 0.9 1.8 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Arm PF00514.23 ADV20388.1 - 2.1e-76 249.9 30.2 2.4e-12 46.4 0.1 11.3 11 0 0 11 11 11 10 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 ADV20388.1 - 2.1e-20 72.9 10.7 0.00068 20.0 0.4 6.9 3 3 1 6 6 6 5 HEAT repeats HEAT_EZ PF13513.6 ADV20388.1 - 5.6e-19 68.2 17.5 0.00014 22.2 0.4 7.9 6 2 2 8 8 8 5 HEAT-like repeat HEAT PF02985.22 ADV20388.1 - 2.5e-18 64.6 15.7 0.091 13.1 0.0 9.6 9 0 0 9 9 9 6 HEAT repeat Arm_2 PF04826.13 ADV20388.1 - 3.8e-13 49.5 6.1 8.5e-10 38.5 1.7 2.5 1 1 1 2 2 2 2 Armadillo-like Adaptin_N PF01602.20 ADV20388.1 - 1.7e-12 46.7 9.6 6.7e-09 34.8 0.3 3.0 2 1 1 3 3 3 2 Adaptin N terminal region KAP PF05804.12 ADV20388.1 - 7.6e-09 34.3 0.4 1e-08 33.9 0.4 1.3 1 0 0 1 1 1 1 Kinesin-associated protein (KAP) Cnd1 PF12717.7 ADV20388.1 - 9.1e-09 35.6 5.1 0.02 15.0 0.1 4.7 2 2 2 5 5 5 4 non-SMC mitotic condensation complex subunit 1 V-ATPase_H_N PF03224.14 ADV20388.1 - 2.4e-08 33.6 5.1 0.0047 16.3 2.9 4.1 1 1 2 3 3 3 2 V-ATPase subunit H DUF3361 PF11841.8 ADV20388.1 - 0.00047 20.1 8.8 0.29 11.1 0.0 4.1 3 2 2 5 5 5 2 Domain of unknown function (DUF3361) Vac14_Fab1_bd PF12755.7 ADV20388.1 - 0.00071 20.1 0.0 1.4 9.6 0.0 3.5 3 1 0 3 3 3 1 Vacuolar 14 Fab1-binding region DUF5578 PF17741.1 ADV20388.1 - 0.0024 17.4 10.0 6.6 6.1 0.0 4.5 1 1 2 4 4 4 2 Family of unknown function (DUF5578) Atx10homo_assoc PF09759.9 ADV20388.1 - 0.075 13.1 4.8 0.4 10.7 0.0 3.8 3 1 2 5 5 4 0 Spinocerebellar ataxia type 10 protein domain HEAT_PBS PF03130.16 ADV20388.1 - 0.12 13.1 12.7 1.7e+02 3.3 0.0 7.6 8 0 0 8 8 7 0 PBS lyase HEAT-like repeat WAPL PF07814.13 ADV20388.1 - 0.13 11.1 5.3 0.26 10.0 1.9 2.4 1 1 1 2 2 2 0 Wings apart-like protein regulation of heterochromatin NopRA1 PF16201.5 ADV20388.1 - 0.16 11.5 1.5 8 6.0 0.0 3.9 4 2 1 6 6 6 0 Nucleolar pre-ribosomal-associated protein 1 Proteasom_PSMB PF10508.9 ADV20388.1 - 0.33 9.4 3.8 4.6 5.6 1.1 2.6 1 1 1 2 2 2 0 Proteasome non-ATPase 26S subunit RasGEF_N_2 PF14663.6 ADV20388.1 - 8.9 6.8 8.4 18 5.8 0.4 3.9 3 1 0 4 4 4 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain Steroid_dh PF02544.16 ADV20389.1 - 3.2e-14 53.2 0.1 9.9e-13 48.3 0.1 2.2 1 1 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.12 ADV20389.1 - 0.11 12.0 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1295) Cupin_8 PF13621.6 ADV20390.1 - 4e-26 92.3 0.0 4.7e-26 92.0 0.0 1.0 1 0 0 1 1 1 1 Cupin-like domain Cupin_2 PF07883.11 ADV20390.1 - 0.053 13.3 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 Cupin domain JmjC PF02373.22 ADV20390.1 - 0.094 13.1 0.0 1.6 9.2 0.0 2.1 2 0 0 2 2 2 0 JmjC domain, hydroxylase HA2 PF04408.23 ADV20391.1 - 5.7e-17 62.0 0.2 2.7e-16 59.8 0.0 2.3 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 ADV20391.1 - 2.7e-13 50.1 0.0 1.2e-12 48.0 0.0 2.1 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 ADV20391.1 - 2.6e-10 40.6 0.1 1.8e-09 38.0 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 ADV20391.1 - 4.8e-08 33.0 0.1 9.4e-08 32.0 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 ADV20391.1 - 4.1e-05 23.9 0.0 0.00014 22.1 0.0 1.9 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 ADV20391.1 - 0.027 15.0 0.0 0.11 13.0 0.0 2.1 1 0 0 1 1 1 0 ABC transporter PhoH PF02562.16 ADV20391.1 - 0.034 13.6 0.0 0.077 12.4 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein T2SSE PF00437.20 ADV20391.1 - 0.046 12.8 0.0 0.11 11.5 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein ALAD PF00490.21 ADV20392.1 - 2.1e-118 395.1 0.0 2.5e-118 394.9 0.0 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase OGG_N PF07934.12 ADV20394.1 - 5e-23 81.5 0.0 9.4e-23 80.6 0.0 1.5 1 0 0 1 1 1 1 8-oxoguanine DNA glycosylase, N-terminal domain HhH-GPD PF00730.25 ADV20394.1 - 5.6e-05 23.5 0.0 0.00011 22.6 0.0 1.5 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 ADV20394.1 - 0.0017 18.1 0.0 0.0035 17.1 0.0 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix motif Mem_trans PF03547.18 ADV20395.1 - 1.4e-19 69.7 6.8 3.1e-17 62.1 5.8 2.4 1 1 0 1 1 1 1 Membrane transport protein Peptidase_S9 PF00326.21 ADV20395.1 - 0.011 15.2 0.0 0.016 14.7 0.0 1.2 1 0 0 1 1 1 0 Prolyl oligopeptidase family Pkinase PF00069.25 ADV20396.1 - 9.1e-44 149.8 0.0 2.8e-29 102.3 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ADV20396.1 - 1.4e-20 73.7 0.0 1.9e-17 63.4 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 ADV20396.1 - 0.00031 20.1 0.0 0.089 12.1 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 ADV20396.1 - 0.031 13.1 0.0 0.071 11.9 0.0 1.5 2 0 0 2 2 2 0 Fungal protein kinase APH PF01636.23 ADV20396.1 - 0.058 13.3 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Ribosomal_L10 PF00466.20 ADV20397.1 - 1.5e-21 76.4 0.0 2.1e-21 75.9 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L10 RL10P_insert PF17777.1 ADV20397.1 - 3.5e-21 75.0 0.0 5.4e-21 74.4 0.0 1.3 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Trehalase PF01204.18 ADV20398.1 - 3.5e-166 554.0 0.0 4.2e-166 553.7 0.0 1.1 1 0 0 1 1 1 1 Trehalase Trehalase_Ca-bi PF07492.11 ADV20398.1 - 2e-15 56.2 0.0 3.4e-15 55.5 0.0 1.4 1 0 0 1 1 1 1 Neutral trehalase Ca2+ binding domain SPC12 PF06645.13 ADV20398.1 - 0.2 11.8 0.1 0.38 10.9 0.1 1.4 1 0 0 1 1 1 0 Microsomal signal peptidase 12 kDa subunit (SPC12) DUF5003 PF16394.5 ADV20400.1 - 0.53 9.4 3.6 0.71 9.0 3.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5003) Macoilin PF09726.9 ADV20400.1 - 3.2 6.2 5.2 3.1 6.2 5.2 1.0 1 0 0 1 1 1 0 Macoilin family Ribosomal_L4 PF00573.22 ADV20401.1 - 2.5e-65 219.7 0.0 3.5e-65 219.3 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family PYC_OADA PF02436.18 ADV20401.1 - 0.12 12.1 0.1 0.2 11.4 0.1 1.3 1 0 0 1 1 1 0 Conserved carboxylase domain Toxin_33 PF08121.11 ADV20401.1 - 2.3 8.1 6.1 4.9 7.0 6.1 1.6 1 0 0 1 1 1 0 Waglerin family SWIM PF04434.17 ADV20402.1 - 4.1e-07 29.5 0.5 7.9e-07 28.6 0.5 1.5 1 0 0 1 1 1 1 SWIM zinc finger zf-RING_2 PF13639.6 ADV20402.1 - 0.00012 22.4 2.6 0.00012 22.4 2.6 2.4 2 1 0 2 2 2 1 Ring finger domain FANCL_C PF11793.8 ADV20402.1 - 0.004 17.3 6.5 0.0054 16.9 2.7 2.4 2 0 0 2 2 2 1 FANCL C-terminal domain PHD PF00628.29 ADV20402.1 - 0.27 11.1 4.9 0.67 9.9 4.9 1.7 1 0 0 1 1 1 0 PHD-finger Prok-RING_1 PF14446.6 ADV20402.1 - 0.61 10.1 8.2 0.74 9.8 4.5 3.0 2 1 0 2 2 2 0 Prokaryotic RING finger family 1 DUF2420 PF10336.9 ADV20403.1 - 3.6e-05 23.7 0.0 0.00011 22.2 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2420) ox_reductase_C PF08635.10 ADV20405.1 - 5.3e-79 262.8 0.1 7.6e-79 262.3 0.1 1.2 1 0 0 1 1 1 1 Putative oxidoreductase C terminal domain GFO_IDH_MocA PF01408.22 ADV20405.1 - 6.2e-28 98.0 0.0 9.4e-28 97.5 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Sugar_tr PF00083.24 ADV20406.1 - 3.7e-113 378.8 21.7 4.4e-113 378.5 21.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ADV20406.1 - 7.2e-21 74.5 38.6 4.4e-17 62.0 9.5 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily MFS_5 PF05631.14 ADV20406.1 - 0.00057 18.9 0.4 0.0011 17.9 0.4 1.5 1 0 0 1 1 1 1 Sugar-tranasporters, 12 TM MFS_1_like PF12832.7 ADV20406.1 - 0.00076 18.4 4.8 0.027 13.3 4.8 3.1 1 1 0 1 1 1 1 MFS_1 like family MFS_3 PF05977.13 ADV20406.1 - 0.03 12.7 1.7 0.21 10.0 0.3 2.0 1 1 0 1 1 1 0 Transmembrane secretion effector TRI12 PF06609.13 ADV20406.1 - 0.14 10.5 7.2 0.57 8.5 1.9 2.1 2 0 0 2 2 2 0 Fungal trichothecene efflux pump (TRI12) SMC_N PF02463.19 ADV20407.1 - 1.7e-56 191.2 20.6 7.4e-56 189.0 20.6 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 ADV20407.1 - 3.5e-29 101.5 0.0 1.1e-28 99.9 0.0 2.0 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 ADV20407.1 - 1.4e-13 51.4 7.8 1.1e-06 28.7 0.0 3.3 3 2 1 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ADV20407.1 - 3.2e-08 33.2 0.3 2.4e-07 30.4 0.0 2.3 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_15 PF13175.6 ADV20407.1 - 1.5e-07 31.5 2.4 1.5e-07 31.5 2.4 3.4 2 1 0 3 3 3 1 AAA ATPase domain IFT57 PF10498.9 ADV20407.1 - 0.002 17.2 7.5 0.002 17.2 7.5 5.6 4 1 1 6 6 6 2 Intra-flagellar transport protein 57 SbcCD_C PF13558.6 ADV20407.1 - 0.0038 17.4 0.0 0.025 14.8 0.0 2.5 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit ABC_tran PF00005.27 ADV20407.1 - 0.019 15.5 0.0 0.019 15.5 0.0 5.4 4 2 0 4 4 4 0 ABC transporter DUF2939 PF11159.8 ADV20407.1 - 0.071 13.5 0.4 2.1 8.8 0.0 3.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2939) Ank_5 PF13857.6 ADV20408.1 - 2e-14 53.5 0.1 1.7e-09 37.8 0.1 2.9 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 ADV20408.1 - 3.3e-14 53.0 0.6 2.4e-06 28.0 0.1 3.3 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 ADV20408.1 - 4.4e-14 52.8 0.0 1.4e-13 51.2 0.0 1.8 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ADV20408.1 - 1e-11 43.9 0.1 0.0002 21.5 0.1 3.9 3 1 0 3 3 3 3 Ankyrin repeat Ank PF00023.30 ADV20408.1 - 6.4e-11 42.2 0.0 6.1e-05 23.3 0.3 3.5 3 0 0 3 3 3 2 Ankyrin repeat DUF4404 PF14357.6 ADV20408.1 - 0.023 15.3 0.7 1.9 9.2 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) DUF1843 PF08898.10 ADV20408.1 - 0.06 13.9 0.5 4.7 7.8 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF1843) Spb1_C PF07780.12 ADV20409.1 - 1.1e-70 237.6 30.0 1.1e-70 237.6 30.0 3.9 3 2 0 4 4 4 1 Spb1 C-terminal domain FtsJ PF01728.19 ADV20409.1 - 2.5e-55 187.3 0.0 4.9e-55 186.4 0.0 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase DUF3381 PF11861.8 ADV20409.1 - 3.8e-46 156.9 9.8 3.8e-46 156.9 9.8 5.5 3 1 1 4 4 4 1 Domain of unknown function (DUF3381) D5_N PF08706.11 ADV20409.1 - 9.4 6.5 11.0 0.74 10.1 2.8 2.8 2 0 0 2 2 2 0 D5 N terminal like Suf PF05843.14 ADV20410.1 - 2.9e-97 326.2 2.8 5.6e-93 312.2 0.0 3.6 3 0 0 3 3 3 1 Suppressor of forked protein (Suf) PT PF04886.12 ADV20410.1 - 2e-13 49.6 71.7 1.7e-08 33.8 31.5 3.3 1 1 1 2 2 2 2 PT repeat TPR_14 PF13428.6 ADV20410.1 - 0.0037 18.0 0.1 0.0037 18.0 0.1 5.7 5 1 2 7 7 7 1 Tetratricopeptide repeat TPR_19 PF14559.6 ADV20410.1 - 0.071 13.6 2.1 33 5.1 0.1 4.2 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 ADV20410.1 - 0.094 12.9 0.2 0.41 10.9 0.2 2.2 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_15 PF13429.6 ADV20410.1 - 0.15 11.3 4.5 0.32 10.2 0.1 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 ADV20410.1 - 0.19 12.0 1.9 0.39 11.0 0.2 2.5 3 0 0 3 3 3 0 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 ADV20410.1 - 2.2 8.2 4.7 28 4.7 0.1 3.5 3 1 0 3 3 3 0 Mad3/BUB1 homology region 1 adh_short_C2 PF13561.6 ADV20412.1 - 2e-33 115.9 0.0 1.1e-25 90.6 0.0 2.0 1 1 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ADV20412.1 - 3.7e-25 88.5 0.4 4.4e-23 81.8 0.4 2.3 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ADV20412.1 - 1.7e-07 31.3 0.2 2.9e-07 30.6 0.2 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ADV20412.1 - 0.017 14.6 0.2 0.03 13.8 0.1 1.4 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family KdpD PF02702.17 ADV20412.1 - 0.11 12.0 0.1 0.16 11.4 0.1 1.1 1 0 0 1 1 1 0 Osmosensitive K+ channel His kinase sensor domain Glycos_transf_2 PF00535.26 ADV20413.1 - 2.7e-31 108.6 0.0 3.4e-31 108.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 ADV20413.1 - 3e-13 50.2 0.0 4.3e-13 49.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 ADV20413.1 - 0.00016 21.2 0.0 0.00021 20.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 ADV20413.1 - 0.2 12.2 0.0 0.38 11.3 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase family 2 Mid1 PF12929.7 ADV20414.1 - 1.2e-37 130.2 0.8 2e-37 129.4 0.8 1.3 1 0 0 1 1 1 1 Stretch-activated Ca2+-permeable channel component Fz PF01392.22 ADV20414.1 - 0.032 14.9 5.4 0.66 10.6 0.5 2.8 2 1 0 2 2 2 0 Fz domain Foie-gras_1 PF11817.8 ADV20416.1 - 4.5e-37 128.1 1.9 2.1e-35 122.6 0.1 2.4 2 0 0 2 2 2 2 Foie gras liver health family 1 DUF908 PF06012.12 ADV20417.1 - 0.76 9.1 5.2 2.5 7.4 5.2 1.8 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) ERM PF00769.19 ADV20417.1 - 4.4 7.0 21.8 15 5.3 20.1 2.3 2 0 0 2 2 2 0 Ezrin/radixin/moesin family RINT1_TIP1 PF04437.13 ADV20418.1 - 2.2e-87 294.0 0.0 3.5e-87 293.4 0.0 1.3 1 0 0 1 1 1 1 RINT-1 / TIP-1 family Sec6 PF06046.13 ADV20418.1 - 0.034 12.5 0.0 0.07 11.5 0.0 1.4 1 0 0 1 1 1 0 Exocyst complex component Sec6 Sec15 PF04091.12 ADV20418.1 - 0.045 13.1 0.0 0.087 12.2 0.0 1.4 1 0 0 1 1 1 0 Exocyst complex subunit Sec15-like RasGAP PF00616.19 ADV20419.1 - 4.5e-37 127.8 0.0 1e-36 126.6 0.0 1.6 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.15 ADV20419.1 - 1.5e-34 119.0 4.1 1.5e-34 119.0 4.1 2.4 2 0 0 2 2 2 1 RasGAP C-terminus IQ PF00612.27 ADV20419.1 - 6e-19 66.0 40.1 0.028 14.2 0.2 13.4 13 0 0 13 13 13 6 IQ calmodulin-binding motif CH PF00307.31 ADV20419.1 - 4.2e-14 52.7 0.0 1e-13 51.4 0.0 1.6 1 0 0 1 1 1 1 Calponin homology (CH) domain YabA PF06156.13 ADV20419.1 - 0.89 10.2 3.2 2.5 8.8 0.2 3.0 2 0 0 2 2 2 0 Initiation control protein YabA DivIC PF04977.15 ADV20419.1 - 2.9 7.7 5.1 2.5 7.9 2.2 2.6 2 0 0 2 2 2 0 Septum formation initiator PQ-loop PF04193.14 ADV20420.1 - 1.1e-28 98.8 12.9 1.3e-17 63.2 0.3 2.8 3 0 0 3 3 3 2 PQ loop repeat YfhO PF09586.10 ADV20420.1 - 0.69 8.1 5.9 0.89 7.7 5.9 1.1 1 0 0 1 1 1 0 Bacterial membrane protein YfhO TMEM40 PF15817.5 ADV20420.1 - 0.94 9.2 6.2 0.16 11.7 0.6 2.2 2 0 0 2 2 2 0 Transmembrane protein 40 family Glyco_transf_20 PF00982.21 ADV20421.1 - 4.9e-141 470.6 0.0 7.7e-109 364.5 0.0 2.7 3 0 0 3 3 3 2 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 ADV20421.1 - 1.1e-69 234.2 0.0 6e-69 231.7 0.0 2.1 2 0 0 2 2 2 1 Trehalose-phosphatase Zn_clus PF00172.18 ADV20422.1 - 5.7e-06 26.4 10.1 1e-05 25.6 10.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 ADV20422.1 - 4.5e-05 22.6 0.0 8.8e-05 21.7 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Hexokinase_1 PF00349.21 ADV20423.1 - 2.2e-74 249.7 0.0 3.4e-74 249.1 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_2 PF03727.16 ADV20423.1 - 2.3e-73 246.6 0.0 3.2e-73 246.1 0.0 1.2 1 0 0 1 1 1 1 Hexokinase UPF0270 PF06794.12 ADV20423.1 - 0.044 13.9 0.0 0.13 12.3 0.0 1.8 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0270) HRDC PF00570.23 ADV20423.1 - 0.11 12.5 0.0 0.27 11.2 0.0 1.6 1 0 0 1 1 1 0 HRDC domain DUF3037 PF11236.8 ADV20424.1 - 3.2 8.2 6.3 2.7 8.4 4.1 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3037) SET PF00856.28 ADV20426.1 - 6.4e-19 69.0 0.0 1.3e-18 68.0 0.0 1.5 1 1 0 1 1 1 1 SET domain Mg_trans_NIPA PF05653.14 ADV20427.1 - 1.4e-12 47.4 18.6 6e-07 28.9 3.1 2.1 2 0 0 2 2 2 2 Magnesium transporter NIPA EamA PF00892.20 ADV20427.1 - 0.00033 20.8 2.6 0.00033 20.8 2.6 3.7 3 1 0 3 3 3 2 EamA-like transporter family PAGK PF15284.6 ADV20427.1 - 0.037 14.0 0.0 0.11 12.4 0.0 1.8 1 0 0 1 1 1 0 Phage-encoded virulence factor DUF2973 PF11189.8 ADV20427.1 - 0.53 10.4 2.6 10 6.3 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2973) Ribosomal_S9 PF00380.19 ADV20428.1 - 8.9e-29 100.5 0.2 1e-28 100.3 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Sad1_UNC PF07738.13 ADV20429.1 - 8e-24 84.1 0.0 1.3e-21 76.9 0.0 2.4 1 1 0 1 1 1 1 Sad1 / UNC-like C-terminal Phage_GP20 PF06810.11 ADV20429.1 - 0.0023 17.8 0.6 0.0071 16.2 0.3 2.0 1 1 0 1 1 1 1 Phage minor structural protein GP20 Filament PF00038.21 ADV20429.1 - 0.0062 16.2 5.3 0.012 15.2 5.3 1.4 1 0 0 1 1 1 1 Intermediate filament protein Mu-like_Pro PF10123.9 ADV20429.1 - 0.0088 15.6 1.1 0.016 14.8 1.1 1.4 1 0 0 1 1 1 1 Mu-like prophage I protein DUF3584 PF12128.8 ADV20429.1 - 0.016 12.7 3.7 0.026 12.1 3.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) MscS_porin PF12795.7 ADV20429.1 - 0.02 14.5 0.6 0.02 14.5 0.6 2.0 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain CCDC-167 PF15188.6 ADV20429.1 - 0.023 15.0 7.5 0.051 13.9 2.0 2.7 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 HMMR_N PF15905.5 ADV20429.1 - 0.059 12.8 6.9 0.14 11.6 6.9 1.5 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Spc7 PF08317.11 ADV20429.1 - 0.07 12.0 5.9 0.18 10.7 5.9 1.6 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF724 PF05266.14 ADV20429.1 - 0.084 12.7 2.3 0.25 11.2 2.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF724) PilJ PF13675.6 ADV20429.1 - 0.085 12.9 1.6 11 6.1 0.3 2.8 1 1 1 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term DUF4407 PF14362.6 ADV20429.1 - 0.13 11.6 6.5 0.038 13.3 0.7 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4407) Fez1 PF06818.15 ADV20429.1 - 0.14 12.6 3.4 0.37 11.2 3.4 1.6 1 0 0 1 1 1 0 Fez1 DUF4763 PF15960.5 ADV20429.1 - 0.16 11.2 2.8 0.45 9.8 2.2 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4763) GvpL_GvpF PF06386.11 ADV20429.1 - 0.19 11.7 3.0 0.43 10.5 0.0 2.4 2 0 0 2 2 2 0 Gas vesicle synthesis protein GvpL/GvpF Atg14 PF10186.9 ADV20429.1 - 0.25 10.4 1.4 0.54 9.3 1.4 1.5 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 TolA_bind_tri PF16331.5 ADV20429.1 - 0.34 11.0 8.1 0.17 12.0 0.2 3.2 3 1 1 4 4 3 0 TolA binding protein trimerisation DUF5082 PF16888.5 ADV20429.1 - 0.41 10.9 6.7 0.82 10.0 2.4 3.1 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) Fib_alpha PF08702.10 ADV20429.1 - 0.64 10.2 4.2 5 7.3 4.2 2.3 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family APG6_N PF17675.1 ADV20429.1 - 1.4 9.4 5.2 7 7.2 5.0 2.3 1 1 0 1 1 1 0 Apg6 coiled-coil region Seryl_tRNA_N PF02403.22 ADV20429.1 - 1.4 9.2 8.1 1.1 9.5 5.0 2.4 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Allexi_40kDa PF05549.11 ADV20429.1 - 1.6 8.2 4.2 5.1 6.5 2.5 2.5 2 2 0 2 2 2 0 Allexivirus 40kDa protein TPR_MLP1_2 PF07926.12 ADV20429.1 - 1.7 8.8 12.2 0.16 12.0 0.4 3.2 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein Prefoldin_2 PF01920.20 ADV20429.1 - 2.1 8.3 6.7 4.1 7.4 0.7 2.8 1 1 0 2 2 2 0 Prefoldin subunit DUF1664 PF07889.12 ADV20429.1 - 2.4 8.2 6.9 3.5 7.7 4.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) HSBP1 PF06825.12 ADV20429.1 - 2.8 7.9 4.2 27 4.7 0.0 3.6 4 0 0 4 4 4 0 Heat shock factor binding protein 1 DUF4140 PF13600.6 ADV20429.1 - 4.2 7.9 10.8 3.7e+02 1.6 7.6 4.1 3 1 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) SWIRM-assoc_1 PF16495.5 ADV20429.1 - 4.8 7.2 6.0 0.67 9.9 0.3 2.4 3 0 0 3 3 2 0 SWIRM-associated region 1 Hydrolase_4 PF12146.8 ADV20430.1 - 2.1e-36 125.4 0.0 2e-21 76.4 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ADV20430.1 - 5.4e-11 42.6 0.0 1.7e-08 34.4 0.0 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ADV20430.1 - 4e-09 37.4 0.1 6.4e-09 36.7 0.1 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 ADV20430.1 - 0.0084 15.6 0.0 1.6 8.2 0.0 2.5 3 0 0 3 3 3 2 Prolyl oligopeptidase family Abhydrolase_2 PF02230.16 ADV20430.1 - 0.018 14.8 0.0 0.13 12.0 0.0 2.2 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase DLH PF01738.18 ADV20430.1 - 0.02 14.5 0.0 0.63 9.5 0.0 2.2 2 1 0 2 2 2 0 Dienelactone hydrolase family Peptidase_S15 PF02129.18 ADV20430.1 - 0.032 13.8 0.0 1.2 8.7 0.0 2.3 2 1 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) Esterase PF00756.20 ADV20430.1 - 0.05 13.3 0.0 0.08 12.6 0.0 1.3 1 0 0 1 1 1 0 Putative esterase Tubulin PF00091.25 ADV20431.1 - 7.1e-66 222.2 0.0 1e-65 221.7 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ADV20431.1 - 5.8e-51 171.9 0.0 9e-51 171.3 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 ADV20431.1 - 0.003 17.3 0.0 0.0055 16.4 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain zf-C2H2_aberr PF17017.5 ADV20432.1 - 0.0034 17.5 0.2 0.0092 16.1 0.0 1.6 2 0 0 2 2 2 1 Aberrant zinc-finger zf-C2H2 PF00096.26 ADV20432.1 - 0.0049 17.3 0.4 0.045 14.2 0.0 2.3 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ADV20432.1 - 0.028 15.3 2.3 0.34 11.9 0.0 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger zf-RRN7 PF11781.8 ADV20432.1 - 0.12 12.1 0.2 0.19 11.4 0.2 1.3 1 0 0 1 1 1 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 KilA-N PF04383.13 ADV20433.1 - 0.0089 15.9 0.1 0.81 9.6 0.1 2.5 1 1 0 1 1 1 1 KilA-N domain PolyA_pol PF01743.20 ADV20434.1 - 1.1e-23 84.0 0.0 2.1e-23 83.1 0.0 1.5 1 0 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 ADV20434.1 - 6.1e-05 22.7 0.0 0.00014 21.6 0.0 1.6 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A Ribosomal_S14 PF00253.21 ADV20435.1 - 1.3e-20 72.9 0.9 2.1e-20 72.2 0.9 1.3 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e Pkinase PF00069.25 ADV20436.1 - 5.1e-38 130.9 0.0 4.9e-23 81.8 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ADV20436.1 - 1e-17 64.3 0.0 2.1e-16 60.0 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ADV20436.1 - 0.0012 18.3 0.0 0.023 14.0 0.0 2.1 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 ADV20436.1 - 0.0043 17.0 0.1 0.019 14.9 0.1 1.9 1 1 0 1 1 1 1 Phosphotransferase enzyme family DNA_topoisoIV PF00521.20 ADV20438.1 - 1.2e-132 442.9 0.0 1.2e-132 442.9 0.0 2.1 3 0 0 3 3 3 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 ADV20438.1 - 7.7e-55 184.6 1.7 2.9e-54 182.7 1.7 2.1 1 0 0 1 1 1 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.25 ADV20438.1 - 3.7e-28 98.2 1.6 9.7e-28 96.8 1.6 1.7 1 0 0 1 1 1 1 DNA gyrase B HATPase_c PF02518.26 ADV20438.1 - 8.2e-12 45.6 0.1 2.4e-11 44.1 0.1 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 ADV20438.1 - 2e-07 31.2 0.0 6.7e-07 29.5 0.0 1.9 1 0 0 1 1 1 1 Toprim domain WAPL PF07814.13 ADV20439.1 - 4.8e-13 48.6 3.9 5.6e-13 48.4 1.1 2.2 2 1 0 2 2 2 1 Wings apart-like protein regulation of heterochromatin PPI_Ypi1 PF07491.11 ADV20440.1 - 4.8e-25 87.2 2.0 4.8e-25 87.2 2.0 2.2 2 1 0 2 2 2 1 Protein phosphatase inhibitor CDC45 PF02724.14 ADV20440.1 - 0.035 12.4 1.0 0.037 12.3 1.0 1.0 1 0 0 1 1 1 0 CDC45-like protein RRP7 PF12923.7 ADV20441.1 - 0.025 14.7 0.2 0.059 13.5 0.2 1.6 1 0 0 1 1 1 0 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain F-box-like PF12937.7 ADV20442.1 - 0.0015 18.4 0.7 0.0034 17.2 0.7 1.7 1 0 0 1 1 1 1 F-box-like Sdh_cyt PF01127.22 ADV20443.1 - 2.4e-24 85.7 2.8 2.8e-24 85.5 2.8 1.1 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit DUF4598 PF15370.6 ADV20444.1 - 4.7e-13 49.6 1.8 4.7e-13 49.6 1.8 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4598) DNA_pol_phi PF04931.13 ADV20444.1 - 1.2 7.1 10.6 1.8 6.6 10.6 1.3 1 0 0 1 1 1 0 DNA polymerase phi AAR2 PF05282.11 ADV20445.1 - 2.5e-72 244.2 0.0 3.4e-72 243.8 0.0 1.2 1 0 0 1 1 1 1 AAR2 protein MMtag PF10159.9 ADV20446.1 - 1.6e-24 85.9 4.6 1.6e-24 85.9 4.6 4.7 2 2 0 3 3 3 1 Multiple myeloma tumor-associated GBS_Bsp-like PF08481.10 ADV20446.1 - 0.04 14.0 1.3 3 8.0 0.6 2.4 1 1 1 2 2 2 0 GBS Bsp-like repeat MCPVI PF02993.14 ADV20446.1 - 0.062 13.1 0.2 0.11 12.3 0.2 1.5 1 0 0 1 1 1 0 Minor capsid protein VI Svf1_C PF17187.4 ADV20447.1 - 6.8e-43 146.3 0.0 1.7e-42 145.0 0.0 1.6 2 0 0 2 2 2 1 Svf1-like C-terminal lipocalin-like domain Svf1 PF08622.10 ADV20447.1 - 1.1e-36 126.4 0.1 1.7e-36 125.7 0.1 1.3 1 0 0 1 1 1 1 Svf1-like N-terminal lipocalin domain RNase_H PF00075.24 ADV20448.1 - 2.2e-32 112.2 0.0 3.3e-32 111.6 0.0 1.2 1 0 0 1 1 1 1 RNase H Cauli_VI PF01693.16 ADV20448.1 - 9e-16 57.9 6.0 1.6e-15 57.1 6.0 1.5 1 0 0 1 1 1 1 Caulimovirus viroplasmin DUF3342 PF11822.8 ADV20448.1 - 0.087 13.0 0.0 0.15 12.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) Ribosomal_L27A PF00828.19 ADV20449.1 - 5.9e-21 75.5 0.1 7.8e-21 75.1 0.1 1.2 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A SNase PF00565.17 ADV20451.1 - 4.1e-49 165.6 0.0 1.2e-17 64.3 0.0 6.9 6 1 0 6 6 6 6 Staphylococcal nuclease homologue TUDOR PF00567.24 ADV20451.1 - 4.5e-24 84.8 0.0 1.1e-23 83.6 0.0 1.5 1 0 0 1 1 1 1 Tudor domain Agenet PF05641.12 ADV20451.1 - 0.0021 18.5 0.2 0.016 15.6 0.1 2.6 2 0 0 2 2 2 1 Agenet domain OB_RNB PF08206.11 ADV20451.1 - 0.014 15.1 0.0 0.04 13.6 0.0 1.9 1 0 0 1 1 1 0 Ribonuclease B OB domain CTP_transf_like PF01467.26 ADV20453.1 - 5.6e-06 26.6 0.0 8.3e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 Cytidylyltransferase-like Chromo PF00385.24 ADV20455.1 - 3.7e-12 46.0 0.1 1.2e-11 44.3 0.1 1.9 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain Mtf2_C PF14061.6 ADV20455.1 - 0.069 13.3 0.2 0.13 12.5 0.2 1.4 1 0 0 1 1 1 0 Polycomb-like MTF2 factor 2 PQ-loop PF04193.14 ADV20456.1 - 2e-30 104.3 12.9 5.7e-16 58.0 0.5 3.0 3 0 0 3 3 3 2 PQ loop repeat ER_lumen_recept PF00810.18 ADV20456.1 - 0.00056 20.8 9.6 0.049 14.5 2.5 3.3 2 1 1 3 3 3 3 ER lumen protein retaining receptor LAB_N PF07578.11 ADV20456.1 - 9.5 6.4 10.4 4.6 7.4 0.7 2.5 2 0 0 2 2 2 0 Lipid A Biosynthesis N-terminal domain RNA_pol_L_2 PF13656.6 ADV20457.1 - 1.2e-27 95.5 0.1 1.6e-27 95.1 0.1 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 ADV20457.1 - 6.1e-09 35.2 0.0 9e-09 34.7 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Optomotor-blind PF11078.8 ADV20458.1 - 0.078 13.6 0.2 0.078 13.6 0.2 1.9 2 0 0 2 2 2 0 Optomotor-blind protein N-terminal region zf-C2H2_10 PF16588.5 ADV20459.1 - 0.11 12.2 0.6 0.19 11.5 0.6 1.4 1 0 0 1 1 1 0 C2H2 zinc-finger DSPn PF14671.6 ADV20459.1 - 0.15 12.5 0.0 0.28 11.6 0.0 1.4 1 0 0 1 1 1 0 Dual specificity protein phosphatase, N-terminal half RmlD_sub_bind PF04321.17 ADV20460.1 - 4e-57 193.5 0.1 4.7e-57 193.3 0.1 1.0 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.21 ADV20460.1 - 1.4e-28 100.0 0.1 1.8e-28 99.7 0.1 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ADV20460.1 - 5.6e-11 42.4 0.1 1.4e-10 41.1 0.1 1.6 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 ADV20460.1 - 3.2e-08 33.1 0.0 2.7e-06 26.7 0.0 2.6 1 1 1 2 2 2 1 Male sterility protein Polysacc_synt_2 PF02719.15 ADV20460.1 - 1.2e-07 31.1 1.0 3.9e-06 26.2 1.0 2.5 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 ADV20460.1 - 0.00026 21.0 0.1 0.00038 20.4 0.1 1.3 1 0 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 ADV20460.1 - 0.00044 19.4 0.0 0.00088 18.4 0.0 1.5 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short PF00106.25 ADV20460.1 - 0.00075 19.0 0.2 0.0025 17.3 0.2 1.9 1 1 0 1 1 1 1 short chain dehydrogenase NmrA PF05368.13 ADV20460.1 - 0.0052 16.4 0.4 1.1 8.8 0.2 2.4 2 1 0 2 2 2 2 NmrA-like family Nif11 PF07862.11 ADV20460.1 - 0.0098 16.2 0.4 0.037 14.3 0.4 2.0 1 1 0 1 1 1 1 Nif11 domain KR PF08659.10 ADV20460.1 - 0.012 15.6 0.2 0.059 13.3 0.1 2.2 2 1 0 2 2 2 0 KR domain DFP PF04127.15 ADV20460.1 - 0.14 12.0 0.2 0.35 10.7 0.1 1.7 2 1 0 2 2 2 0 DNA / pantothenate metabolism flavoprotein Actin PF00022.19 ADV20461.1 - 6.3e-29 100.8 0.0 6.8e-16 57.9 0.0 3.0 2 1 0 2 2 2 2 Actin Actin_micro PF17003.5 ADV20461.1 - 2.2e-07 30.4 0.0 0.0028 16.9 0.0 2.2 2 0 0 2 2 2 2 Putative actin-like family MreB_Mbl PF06723.13 ADV20461.1 - 0.0033 16.3 0.0 0.27 10.0 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein CSN8_PSD8_EIF3K PF10075.9 ADV20462.1 - 6.1e-19 68.4 0.0 1.2e-18 67.5 0.0 1.5 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family Tyr_Deacylase PF02580.16 ADV20463.1 - 9.1e-49 165.7 0.0 1.3e-48 165.2 0.0 1.2 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase WSC PF01822.19 ADV20464.1 - 0.0013 18.8 7.0 0.076 13.2 1.0 2.4 2 0 0 2 2 2 2 WSC domain Kinesin PF00225.23 ADV20465.1 - 5.3e-83 278.7 0.1 8.1e-83 278.1 0.1 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ADV20465.1 - 1.8e-25 89.6 0.0 3.3e-25 88.8 0.0 1.4 1 0 0 1 1 1 1 Microtubule binding TPR_19 PF14559.6 ADV20465.1 - 0.0071 16.8 0.5 0.017 15.6 0.5 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat MFS_1 PF07690.16 ADV20466.1 - 5.1e-22 78.3 53.0 1.9e-20 73.1 53.2 2.8 2 1 0 2 2 2 1 Major Facilitator Superfamily Chloroa_b-bind PF00504.21 ADV20466.1 - 0.18 12.4 0.6 0.77 10.3 0.1 2.2 2 0 0 2 2 2 0 Chlorophyll A-B binding protein Rft-1 PF04506.13 ADV20467.1 - 3.9e-92 309.6 4.3 1.6e-91 307.6 4.3 1.7 1 1 0 1 1 1 1 Rft protein HIG_1_N PF04588.13 ADV20467.1 - 1.3 9.3 5.5 22 5.4 0.0 3.8 4 0 0 4 4 4 0 Hypoxia induced protein conserved region Fungal_trans_2 PF11951.8 ADV20468.1 - 6.1e-43 147.1 0.3 8.7e-43 146.6 0.3 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ADV20468.1 - 2.9e-05 24.1 11.8 5e-05 23.3 11.8 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SUIM_assoc PF16619.5 ADV20468.1 - 0.011 15.7 0.1 0.011 15.7 0.1 2.2 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 TFIIA PF03153.13 ADV20468.1 - 1.9 8.4 14.3 4.9 7.0 1.8 2.3 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Med3 PF11593.8 ADV20468.1 - 2.1 7.5 14.6 0.81 8.8 3.1 2.4 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal DAZAP2 PF11029.8 ADV20468.1 - 4.9 8.1 17.1 0.91 10.5 11.7 2.4 2 0 0 2 2 2 0 DAZ associated protein 2 (DAZAP2) MFS_1 PF07690.16 ADV20469.1 - 1.7e-45 155.5 52.8 4.4e-41 141.0 52.5 3.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 ADV20469.1 - 2e-11 43.0 10.8 2e-11 43.0 10.8 1.5 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Ceramidase PF05875.12 ADV20469.1 - 0.026 14.0 11.7 0.0098 15.4 7.7 2.0 1 1 1 2 2 2 0 Ceramidase Flavi_NS4A PF01350.17 ADV20469.1 - 7.4 6.5 7.3 0.88 9.5 1.0 2.6 3 0 0 3 3 3 0 Flavivirus non-structural protein NS4A EPSP_synthase PF00275.20 ADV20470.1 - 1.8e-123 412.3 0.0 3.5e-123 411.4 0.0 1.4 1 0 0 1 1 1 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) DHQ_synthase PF01761.20 ADV20470.1 - 1.2e-98 329.5 0.1 4.7e-97 324.2 0.0 2.3 2 0 0 2 2 2 1 3-dehydroquinate synthase DHquinase_I PF01487.15 ADV20470.1 - 2.8e-46 158.6 0.0 6.2e-46 157.5 0.0 1.6 1 0 0 1 1 1 1 Type I 3-dehydroquinase SKI PF01202.22 ADV20470.1 - 2.7e-27 95.8 0.1 1.3e-26 93.6 0.1 2.1 2 0 0 2 2 2 1 Shikimate kinase Shikimate_dh_N PF08501.11 ADV20470.1 - 1.9e-23 82.5 0.0 7.1e-23 80.7 0.0 2.1 2 0 0 2 2 2 1 Shikimate dehydrogenase substrate binding domain Fe-ADH_2 PF13685.6 ADV20470.1 - 1.2e-08 35.0 0.4 5.6e-08 32.8 0.0 2.2 2 0 0 2 2 2 1 Iron-containing alcohol dehydrogenase SDH_C PF18317.1 ADV20470.1 - 1.5e-08 34.3 2.3 1.9e-08 33.9 0.1 2.4 2 0 0 2 2 2 1 Shikimate 5'-dehydrogenase C-terminal domain Shikimate_DH PF01488.20 ADV20470.1 - 7.9e-06 26.0 0.0 2.2e-05 24.5 0.0 1.7 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Fe-ADH PF00465.19 ADV20470.1 - 0.008 15.0 3.8 0.027 13.3 0.6 2.8 3 0 0 3 3 3 1 Iron-containing alcohol dehydrogenase zf-C2HC5 PF06221.13 ADV20471.1 - 1.3e-16 60.3 8.2 1.9e-16 59.8 8.2 1.3 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type PWI PF01480.17 ADV20471.1 - 0.00016 21.9 0.0 0.00039 20.7 0.0 1.5 1 0 0 1 1 1 1 PWI domain Spectrin_like PF18373.1 ADV20471.1 - 0.00093 19.2 0.0 0.0017 18.4 0.0 1.4 1 0 0 1 1 1 1 Spectrin like domain PHD PF00628.29 ADV20472.1 - 3.6e-06 26.7 3.5 3.6e-06 26.7 3.5 3.2 3 1 1 4 4 4 1 PHD-finger GAT PF03127.14 ADV20472.1 - 0.21 11.9 3.2 0.97 9.8 0.4 2.7 3 0 0 3 3 3 0 GAT domain NDC10_II PF16787.5 ADV20473.1 - 7.1e-37 127.1 0.0 1.7e-24 86.5 0.0 2.2 1 1 1 2 2 2 2 Centromere DNA-binding protein complex CBF3 subunit, domain 2 Abhydrolase_3 PF07859.13 ADV20474.1 - 1.4e-30 106.8 0.0 1e-22 81.0 0.0 2.5 2 0 0 2 2 2 2 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 ADV20474.1 - 0.035 13.0 0.0 0.058 12.3 0.0 1.2 1 0 0 1 1 1 0 Steryl acetyl hydrolase FTR1 PF03239.14 ADV20475.1 - 2.1e-46 158.5 1.6 1.9e-23 83.1 2.6 2.0 2 0 0 2 2 2 2 Iron permease FTR1 family Hum_adeno_E3A PF05393.11 ADV20475.1 - 0.042 13.8 0.2 0.085 12.8 0.2 1.5 1 0 0 1 1 1 0 Human adenovirus early E3A glycoprotein Pox_A14 PF05767.12 ADV20475.1 - 0.96 9.6 2.7 2.5 8.3 0.2 2.6 2 0 0 2 2 2 0 Poxvirus virion envelope protein A14 DUF1295 PF06966.12 ADV20476.1 - 1.1e-30 106.9 0.7 4.5e-14 52.5 0.0 2.5 1 1 1 2 2 2 2 Protein of unknown function (DUF1295) tRNA-synt_1 PF00133.22 ADV20477.1 - 3.3e-214 712.6 0.3 3.8e-213 709.1 0.3 2.1 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 ADV20477.1 - 8.1e-36 123.3 0.0 2.2e-35 121.9 0.0 1.7 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 ADV20477.1 - 2.3e-13 49.7 0.4 2e-07 30.1 0.1 4.4 4 1 0 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 ADV20477.1 - 6e-08 32.4 0.0 3.3e-07 30.0 0.0 3.1 3 1 1 4 4 4 2 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.19 ADV20477.1 - 0.14 11.5 1.1 2.3 7.5 0.0 2.8 3 0 0 3 3 3 0 tRNA synthetases class I (C) catalytic domain zf-C3HC4_3 PF13920.6 ADV20478.1 - 0.41 10.5 12.2 0.73 9.7 12.2 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) CCD48 PF15799.5 ADV20479.1 - 0.11 10.8 1.2 0.14 10.4 1.2 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 48 LRR_6 PF13516.6 ADV20481.1 - 2.8e-08 33.1 2.3 0.81 9.9 0.0 4.7 5 0 0 5 5 5 3 Leucine Rich repeat LRR_4 PF12799.7 ADV20481.1 - 1.4 9.4 10.6 17 6.0 0.8 4.7 4 1 1 5 5 5 0 Leucine Rich repeats (2 copies) ABC_membrane PF00664.23 ADV20482.1 - 2e-53 181.8 5.4 2.7e-53 181.4 5.4 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 ADV20482.1 - 2.3e-34 118.9 0.0 1.3e-33 116.5 0.0 2.2 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.19 ADV20482.1 - 0.00018 21.0 0.4 0.041 13.3 0.0 2.3 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain Zeta_toxin PF06414.12 ADV20482.1 - 0.00022 20.6 0.0 0.00057 19.2 0.0 1.7 2 0 0 2 2 2 1 Zeta toxin AAA PF00004.29 ADV20482.1 - 0.026 15.0 0.5 0.35 11.3 0.1 2.7 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 ADV20482.1 - 0.048 13.4 0.3 0.13 12.0 0.3 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_ATPase PF09818.9 ADV20482.1 - 0.11 11.2 1.3 0.19 10.5 0.2 1.9 2 0 0 2 2 2 0 Predicted ATPase of the ABC class AAA_22 PF13401.6 ADV20482.1 - 0.16 12.3 1.7 3.1 8.1 0.3 2.9 2 1 0 2 2 2 0 AAA domain AAA_16 PF13191.6 ADV20482.1 - 0.56 10.6 3.1 1.3 9.4 0.4 2.6 2 1 0 2 2 2 0 AAA ATPase domain adh_short PF00106.25 ADV20483.1 - 7.4e-39 133.2 0.0 1.1e-38 132.6 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ADV20483.1 - 1.6e-33 116.3 0.0 2e-33 115.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ADV20483.1 - 5e-08 33.1 0.0 1.4e-07 31.6 0.0 1.7 1 1 1 2 2 2 1 KR domain Epimerase PF01370.21 ADV20483.1 - 0.0019 17.7 0.1 0.0085 15.6 0.1 2.0 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family FKBP_C PF00254.28 ADV20484.1 - 6.5e-32 109.7 0.0 8.2e-32 109.4 0.0 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Acyl_transf_1 PF00698.21 ADV20485.1 - 0.053 13.0 0.2 0.27 10.7 0.0 1.9 2 0 0 2 2 2 0 Acyl transferase domain FAD-oxidase_C PF02913.19 ADV20486.1 - 2.5e-56 191.1 0.0 3.5e-56 190.6 0.0 1.1 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 ADV20486.1 - 5.5e-36 123.4 0.2 9.3e-36 122.6 0.2 1.4 1 0 0 1 1 1 1 FAD binding domain Transket_pyr PF02779.24 ADV20487.1 - 6.2e-64 214.9 0.0 9.4e-64 214.4 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.20 ADV20487.1 - 2.1e-63 214.1 0.0 2.9e-63 213.6 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component OxoGdeHyase_C PF16870.5 ADV20487.1 - 4.8e-52 175.7 0.0 7.6e-52 175.1 0.0 1.3 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal 2-oxogl_dehyd_N PF16078.5 ADV20487.1 - 4e-10 39.1 1.3 7.2e-10 38.3 0.1 2.1 2 0 0 2 2 2 1 2-oxoglutarate dehydrogenase N-terminus TRAPP PF04051.16 ADV20488.1 - 2.4e-42 144.1 0.0 2.9e-42 143.9 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Lactamase_B_4 PF13691.6 ADV20488.1 - 0.11 12.1 0.0 0.24 11.1 0.0 1.5 1 0 0 1 1 1 0 tRNase Z endonuclease RNase_H2_suC PF08615.11 ADV20489.1 - 2.9e-38 131.2 0.0 5.6e-37 127.1 0.0 2.1 1 1 0 1 1 1 1 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) Mem_trans PF03547.18 ADV20489.1 - 0.13 10.7 0.2 0.19 10.1 0.2 1.1 1 0 0 1 1 1 0 Membrane transport protein Presenilin PF01080.17 ADV20489.1 - 0.21 10.3 0.5 0.23 10.2 0.5 1.1 1 0 0 1 1 1 0 Presenilin Metallophos PF00149.28 ADV20490.1 - 9.1e-35 121.0 0.0 1.3e-34 120.5 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 ADV20490.1 - 7.1e-16 58.4 0.0 2.1e-15 56.9 0.0 1.8 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain CPL PF08144.11 ADV20491.1 - 2.8e-28 99.1 0.0 1e-25 90.8 0.0 2.9 2 0 0 2 2 2 2 CPL (NUC119) domain JHD PF17811.1 ADV20492.1 - 0.1 13.1 0.1 0.38 11.3 0.1 1.9 1 1 0 1 1 1 0 Jumonji helical domain Y_phosphatase PF00102.27 ADV20493.1 - 0.083 12.4 0.0 0.087 12.4 0.0 1.0 1 0 0 1 1 1 0 Protein-tyrosine phosphatase RhoGEF PF00621.20 ADV20494.1 - 6.2e-30 104.8 0.5 8.9e-30 104.3 0.5 1.2 1 0 0 1 1 1 1 RhoGEF domain CNH PF00780.22 ADV20494.1 - 4e-16 59.5 0.0 7.4e-16 58.6 0.0 1.4 1 0 0 1 1 1 1 CNH domain Pro_isomerase PF00160.21 ADV20495.1 - 3.6e-42 144.3 0.0 7.2e-42 143.3 0.0 1.5 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD WD40 PF00400.32 ADV20495.1 - 0.0002 22.1 0.1 21 6.2 0.0 4.9 5 0 0 5 5 5 2 WD domain, G-beta repeat Alg14 PF08660.11 ADV20496.1 - 4.3e-55 186.3 0.0 5.9e-55 185.9 0.0 1.2 1 0 0 1 1 1 1 Oligosaccharide biosynthesis protein Alg14 like Adap_comp_sub PF00928.21 ADV20497.1 - 5.8e-85 284.9 0.0 7.7e-85 284.4 0.0 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 ADV20497.1 - 2.1e-07 31.0 1.7 3.7e-07 30.2 1.7 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain muHD PF10291.9 ADV20497.1 - 0.083 12.3 0.1 0.16 11.4 0.1 1.4 1 0 0 1 1 1 0 Muniscin C-terminal mu homology domain DUF11 PF01345.18 ADV20497.1 - 0.099 13.0 0.1 0.21 11.9 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function DUF11 Ribosomal_L11_N PF03946.14 ADV20498.1 - 3.3e-27 94.1 1.0 6.1e-27 93.3 1.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 ADV20498.1 - 6.6e-24 84.2 0.3 1.1e-23 83.5 0.3 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain TPT PF03151.16 ADV20499.1 - 2.3e-05 23.9 0.6 3.1e-05 23.5 0.6 1.4 1 0 0 1 1 1 1 Triose-phosphate Transporter family LapA_dom PF06305.11 ADV20500.1 - 0.0018 18.0 0.6 0.0036 17.1 0.6 1.4 1 0 0 1 1 1 1 Lipopolysaccharide assembly protein A domain PepSY_TM PF03929.16 ADV20500.1 - 0.011 15.5 0.2 0.024 14.3 0.2 1.6 1 0 0 1 1 1 0 PepSY-associated TM region DUF2407_C PF13373.6 ADV20500.1 - 0.084 13.1 0.0 0.23 11.6 0.0 1.8 2 0 0 2 2 2 0 DUF2407 C-terminal domain DEAD PF00270.29 ADV20501.1 - 2.3e-49 167.6 0.0 4e-47 160.2 0.0 2.3 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.31 ADV20501.1 - 1.8e-27 95.9 0.0 3.9e-27 94.8 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 ADV20501.1 - 3.7e-05 23.8 0.0 0.00013 22.1 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit CAP_GLY PF01302.25 ADV20502.1 - 2e-21 75.8 0.5 3e-21 75.2 0.5 1.3 1 0 0 1 1 1 1 CAP-Gly domain Ubiquitin_2 PF14560.6 ADV20502.1 - 2.5e-20 72.7 0.0 3.6e-20 72.2 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-like domain ubiquitin PF00240.23 ADV20502.1 - 0.0025 17.5 0.2 0.15 11.9 0.1 2.3 2 0 0 2 2 2 1 Ubiquitin family Apolipoprotein PF01442.18 ADV20504.1 - 0.0033 17.3 0.3 0.0066 16.3 0.3 1.5 1 1 0 1 1 1 1 Apolipoprotein A1/A4/E domain ApoLp-III PF07464.11 ADV20504.1 - 0.0082 16.2 2.1 0.015 15.4 1.6 1.7 1 1 0 1 1 1 1 Apolipophorin-III precursor (apoLp-III) DUF883 PF05957.13 ADV20504.1 - 0.02 15.5 0.3 5.6 7.6 0.0 2.5 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF883) Phasin_2 PF09361.10 ADV20504.1 - 0.021 15.1 0.5 2.2 8.6 0.0 2.4 2 1 0 2 2 2 0 Phasin protein FIVAR PF07554.13 ADV20504.1 - 0.028 15.2 4.5 0.78 10.5 0.0 3.5 2 1 1 3 3 3 0 FIVAR domain YtxH PF12732.7 ADV20504.1 - 0.34 11.5 4.7 12 6.5 0.2 2.8 2 1 0 2 2 2 0 YtxH-like protein Metallophos PF00149.28 ADV20505.1 - 3.2e-40 138.8 0.1 4.2e-40 138.4 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 ADV20505.1 - 8.1e-22 77.4 0.3 1.8e-21 76.3 0.1 1.7 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain SRP_TPR_like PF17004.5 ADV20506.1 - 1.4e-17 63.8 0.2 1.9e-17 63.3 0.2 1.2 1 0 0 1 1 1 1 Putative TPR-like repeat ANAPC3 PF12895.7 ADV20506.1 - 2.1e-07 31.1 11.6 0.00034 20.8 0.5 2.4 1 1 2 3 3 3 3 Anaphase-promoting complex, cyclosome, subunit 3 SRP72 PF08492.12 ADV20506.1 - 3.3e-07 30.6 0.3 3.3e-07 30.6 0.3 2.2 2 0 0 2 2 2 1 SRP72 RNA-binding domain TPR_19 PF14559.6 ADV20506.1 - 3.7e-07 30.5 1.9 0.085 13.4 0.0 3.3 1 1 1 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.6 ADV20506.1 - 7e-05 22.6 1.3 0.14 12.3 0.1 3.1 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ADV20506.1 - 0.0014 18.6 6.4 0.36 11.1 0.5 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat DUF5588 PF17826.1 ADV20506.1 - 0.004 16.1 0.0 0.0057 15.6 0.0 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5588) TPR_14 PF13428.6 ADV20506.1 - 0.0055 17.4 0.3 1.9 9.5 0.0 3.3 2 2 1 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 ADV20506.1 - 0.021 15.5 0.5 1 10.0 0.0 2.7 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_15 PF13429.6 ADV20506.1 - 0.025 13.8 0.3 0.42 9.8 0.0 2.0 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 ADV20506.1 - 0.039 14.2 4.5 0.32 11.3 0.2 3.2 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 ADV20506.1 - 0.11 12.8 3.7 8.5 6.9 0.3 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 ADV20506.1 - 0.16 11.8 5.2 7.1 6.6 0.5 3.5 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 ADV20506.1 - 0.19 12.4 1.4 4.6 8.1 0.2 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat RRM_2 PF04059.12 ADV20507.1 - 3.1e-34 117.1 0.1 5.6e-34 116.2 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif 2 RRM_1 PF00076.22 ADV20507.1 - 9.9e-09 34.9 0.1 0.024 14.5 0.0 3.5 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Bestrophin PF01062.21 ADV20508.1 - 1.4e-08 34.5 0.0 0.00026 20.5 0.0 2.1 2 0 0 2 2 2 2 Bestrophin, RFP-TM, chloride channel Synapsin_N PF10581.9 ADV20508.1 - 0.049 13.6 0.9 1 9.3 0.0 3.2 3 0 0 3 3 3 0 Synapsin N-terminal Kelch_2 PF07646.15 ADV20508.1 - 0.15 12.1 0.3 1.4 9.0 0.1 2.3 2 0 0 2 2 2 0 Kelch motif DivIC PF04977.15 ADV20510.1 - 0.0075 16.0 8.2 0.0075 16.0 8.2 3.4 2 1 1 3 3 3 1 Septum formation initiator TMPIT PF07851.13 ADV20510.1 - 0.036 13.3 0.3 0.036 13.3 0.3 2.3 1 1 1 2 2 2 0 TMPIT-like protein FapA PF03961.13 ADV20510.1 - 0.045 12.4 8.2 0.064 11.9 8.2 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A Spc24 PF08286.11 ADV20510.1 - 0.079 13.2 0.4 0.079 13.2 0.4 3.0 2 1 1 3 3 3 0 Spc24 subunit of Ndc80 FAM76 PF16046.5 ADV20510.1 - 0.53 9.6 11.0 0.92 8.8 11.0 1.3 1 0 0 1 1 1 0 FAM76 protein DUF724 PF05266.14 ADV20510.1 - 3.3 7.5 14.9 1.7 8.4 5.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF724) LMBR1 PF04791.16 ADV20510.1 - 7 5.4 5.6 8.6 5.1 5.6 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DPBB_1 PF03330.18 ADV20511.1 - 0.00024 21.3 0.0 0.00074 19.7 0.0 2.0 1 1 0 1 1 1 1 Lytic transglycolase Abhydrolase_6 PF12697.7 ADV20512.1 - 0.001 19.7 0.1 0.0021 18.7 0.2 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 ADV20512.1 - 0.0014 18.3 0.0 0.006 16.3 0.0 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_M3 PF01432.20 ADV20513.1 - 2.2e-121 406.3 0.0 3.2e-121 405.8 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M3 Peptidase_M91 PF14891.6 ADV20513.1 - 0.06 13.7 0.0 0.11 12.8 0.0 1.3 1 0 0 1 1 1 0 Effector protein NmrA PF05368.13 ADV20514.1 - 0.00047 19.8 0.1 0.00065 19.3 0.1 1.2 1 0 0 1 1 1 1 NmrA-like family MFS_1 PF07690.16 ADV20515.1 - 4.8e-30 104.7 45.3 3.9e-29 101.7 43.5 2.4 2 1 0 2 2 2 2 Major Facilitator Superfamily NTF2 PF02136.20 ADV20516.1 - 7.6e-27 94.3 0.1 1.2e-26 93.7 0.1 1.3 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain RRM_1 PF00076.22 ADV20516.1 - 4e-08 33.0 0.3 7.8e-08 32.0 0.3 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Methyltr_RsmB-F PF01189.17 ADV20517.1 - 4.3e-76 255.0 0.0 7e-76 254.3 0.0 1.3 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltr_RsmF_N PF17125.5 ADV20517.1 - 2.9e-09 37.3 0.0 1e-08 35.5 0.0 2.0 2 0 0 2 2 2 1 N-terminal domain of 16S rRNA methyltransferase RsmF FtsJ PF01728.19 ADV20517.1 - 0.015 15.4 0.0 0.023 14.8 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase PCMT PF01135.19 ADV20517.1 - 0.093 12.5 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DUF3808 PF10300.9 ADV20518.1 - 5.7e-81 272.7 0.0 9.4e-81 271.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) TPR_2 PF07719.17 ADV20518.1 - 9.4e-07 28.5 6.1 0.21 11.8 0.2 4.9 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.6 ADV20518.1 - 0.0057 16.9 0.6 4.8 7.5 0.0 3.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 ADV20518.1 - 0.064 13.9 0.3 2.1 9.1 0.0 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 ADV20518.1 - 0.071 13.2 0.9 1.2 9.3 0.0 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 ADV20518.1 - 0.64 10.4 3.2 0.69 10.3 0.1 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 ADV20518.1 - 3.1 7.8 7.2 11 6.0 0.6 4.3 6 0 0 6 6 6 0 Tetratricopeptide repeat PH PF00169.29 ADV20520.1 - 1.1e-10 41.9 0.0 0.0002 21.8 0.0 2.6 2 0 0 2 2 2 2 PH domain PH_9 PF15410.6 ADV20520.1 - 6.3e-08 33.0 0.0 5e-05 23.7 0.1 2.4 2 0 0 2 2 2 2 Pleckstrin homology domain PH_11 PF15413.6 ADV20520.1 - 0.039 14.4 0.0 17 5.9 0.0 2.6 2 0 0 2 2 2 0 Pleckstrin homology domain BSP_II PF05432.11 ADV20520.1 - 0.84 9.3 16.1 1.5 8.5 5.9 2.6 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) TPR_1 PF00515.28 ADV20521.1 - 6.7e-21 73.2 12.0 3.4e-06 26.7 0.0 5.4 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.17 ADV20521.1 - 1e-17 62.8 12.8 9e-05 22.3 0.3 5.4 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 ADV20521.1 - 5.3e-15 54.3 7.8 0.00083 19.4 0.2 5.5 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_11 PF13414.6 ADV20521.1 - 1.5e-14 53.4 6.3 2.4e-06 27.1 0.0 4.8 2 2 2 4 4 4 3 TPR repeat TPR_17 PF13431.6 ADV20521.1 - 1.6e-14 53.1 5.8 0.00067 19.9 0.2 5.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 ADV20521.1 - 4.2e-12 45.2 7.3 0.0052 16.7 0.0 5.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 ADV20521.1 - 7e-12 45.1 10.5 0.00059 20.4 0.0 5.9 2 2 4 6 6 6 5 Tetratricopeptide repeat TPR_16 PF13432.6 ADV20521.1 - 2.4e-11 44.1 11.3 1.3e-07 32.1 1.3 4.0 2 2 1 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.6 ADV20521.1 - 2.4e-09 37.6 7.9 7.1e-06 26.4 0.7 3.4 2 2 2 4 4 4 3 Tetratricopeptide repeat TPR_20 PF14561.6 ADV20521.1 - 6e-08 32.9 5.0 0.013 15.8 0.4 4.2 2 2 1 3 3 3 3 Tetratricopeptide repeat TPR_9 PF13371.6 ADV20521.1 - 7e-07 29.3 7.3 5e-05 23.4 0.2 3.7 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 ADV20521.1 - 5.2e-06 26.7 11.9 0.0034 17.6 3.9 5.2 4 2 1 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 ADV20521.1 - 5.6e-06 26.7 7.4 0.55 11.0 0.4 5.2 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_3 PF07720.12 ADV20521.1 - 0.00086 19.3 5.7 0.066 13.2 0.0 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_4 PF07721.14 ADV20521.1 - 0.0081 16.7 0.1 9.2 7.2 0.0 3.4 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 ADV20521.1 - 0.012 15.4 18.8 0.032 14.1 0.5 4.3 5 0 0 5 5 4 0 Tetratricopeptide repeat Cas_APE2256 PF09651.10 ADV20521.1 - 0.027 14.3 0.0 0.051 13.5 0.0 1.4 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_APE2256) ANAPC5 PF12862.7 ADV20521.1 - 0.053 13.6 0.5 7.4 6.7 0.1 2.7 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 5 Wzy_C_2 PF11846.8 ADV20521.1 - 0.093 12.6 1.8 11 5.9 0.0 2.9 2 1 1 3 3 3 0 Virulence factor membrane-bound polymerase, C-terminal ANAPC3 PF12895.7 ADV20521.1 - 0.6 10.4 5.9 11 6.3 0.1 2.8 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 Chromo PF00385.24 ADV20522.1 - 1.8e-09 37.4 0.2 5.8e-09 35.7 0.2 1.8 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain PHD PF00628.29 ADV20522.1 - 0.00013 21.7 3.1 0.00032 20.5 3.1 1.5 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 ADV20522.1 - 0.0049 16.4 3.3 0.01 15.4 3.3 1.5 1 0 0 1 1 1 1 PHD-finger PHD_4 PF16866.5 ADV20522.1 - 0.02 15.0 1.9 0.02 15.0 1.9 2.2 2 0 0 2 2 2 0 PHD-finger SURF2 PF05477.11 ADV20522.1 - 1 9.0 4.3 2.3 7.8 4.3 1.5 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) RRM_1 PF00076.22 ADV20523.1 - 5.2e-21 74.2 0.0 4.7e-19 68.0 0.0 3.0 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Glyco_transf_90 PF05686.12 ADV20524.1 - 3e-10 39.6 0.1 1.7e-09 37.1 0.1 2.0 1 1 0 1 1 1 1 Glycosyl transferase family 90 Ribosomal_L16 PF00252.18 ADV20525.1 - 1.5e-45 154.5 0.1 1.9e-45 154.1 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e Zn_clus PF00172.18 ADV20526.1 - 3.7e-05 23.7 7.2 5.7e-05 23.2 7.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AT_hook PF02178.19 ADV20526.1 - 0.0032 17.2 3.6 0.013 15.3 3.6 2.2 1 0 0 1 1 1 1 AT hook motif PIN_4 PF13638.6 ADV20526.1 - 0.061 13.6 0.3 0.089 13.1 0.3 1.2 1 0 0 1 1 1 0 PIN domain GATase_4 PF13230.6 ADV20527.1 - 3.4e-15 55.7 0.0 4.1e-13 48.8 0.0 2.8 2 1 0 2 2 2 2 Glutamine amidotransferases class-II GATase_6 PF13522.6 ADV20527.1 - 2.3e-07 31.1 0.0 5e-07 30.0 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain Helicase_RecD PF05127.14 ADV20527.1 - 0.03 14.2 0.0 0.073 12.9 0.0 1.6 1 1 1 2 2 2 0 Helicase Fungal_trans PF04082.18 ADV20528.1 - 5.4e-13 48.6 0.5 8.9e-13 47.9 0.5 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Gcn1_N PF12074.8 ADV20530.1 - 3.7e-93 312.7 2.3 6.9e-91 305.2 0.4 3.9 4 0 0 4 4 4 1 Generalcontrol nonderepressible 1 (Gcn1) N-terminal HEAT PF02985.22 ADV20530.1 - 4.2e-37 123.0 14.2 0.23 11.8 0.0 20.3 20 0 0 20 20 19 10 HEAT repeat HEAT_EZ PF13513.6 ADV20530.1 - 7.9e-35 118.9 22.6 1.5e-05 25.4 0.0 16.5 16 1 1 17 17 15 8 HEAT-like repeat HEAT_2 PF13646.6 ADV20530.1 - 1.3e-24 86.3 40.3 0.00042 20.6 0.1 15.6 11 2 6 17 17 17 7 HEAT repeats Cnd1 PF12717.7 ADV20530.1 - 2.7e-16 60.0 0.0 0.013 15.6 0.0 8.0 4 1 3 8 8 8 3 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 ADV20530.1 - 1e-11 44.8 0.0 0.012 15.2 0.1 6.3 4 1 3 7 7 7 2 CLASP N terminal Adaptin_N PF01602.20 ADV20530.1 - 1.3e-11 43.8 1.9 0.006 15.2 0.0 8.0 7 1 0 7 7 7 3 Adaptin N terminal region Vac14_Fab1_bd PF12755.7 ADV20530.1 - 8.5e-10 39.1 0.0 1.8 9.2 0.0 7.8 7 1 1 8 8 7 2 Vacuolar 14 Fab1-binding region MMS19_C PF12460.8 ADV20530.1 - 8.5e-08 31.7 10.6 0.063 12.4 0.0 7.6 6 2 0 7 7 7 2 RNAPII transcription regulator C-terminal Arm PF00514.23 ADV20530.1 - 8.8e-06 25.6 0.6 0.73 10.0 0.0 6.4 5 0 0 5 5 5 1 Armadillo/beta-catenin-like repeat Ecm29 PF13001.7 ADV20530.1 - 0.00041 19.2 10.4 0.35 9.5 0.0 6.3 7 2 1 8 8 8 2 Proteasome stabiliser DUF3535 PF12054.8 ADV20530.1 - 0.002 17.4 5.7 0.017 14.4 0.1 4.5 4 1 1 5 5 5 1 Domain of unknown function (DUF3535) Cohesin_HEAT PF12765.7 ADV20530.1 - 0.016 15.5 6.3 0.12 12.7 0.7 5.0 5 0 0 5 5 5 0 HEAT repeat associated with sister chromatid cohesion Spidroin_N PF16763.5 ADV20530.1 - 0.51 10.4 3.2 7.7 6.6 0.1 3.5 3 0 0 3 3 2 0 Major ampullate spidroin 1, spider silk protein 1, N-term Acyl-CoA_dh_1 PF00441.24 ADV20532.1 - 1.9e-32 112.5 2.1 2.9e-32 112.0 2.1 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 ADV20532.1 - 3.3e-15 56.0 0.3 1.3e-14 54.1 0.3 1.9 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Cyt-b5 PF00173.28 ADV20532.1 - 3.9e-15 55.8 0.0 1.1e-14 54.3 0.0 1.9 1 1 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Acyl-CoA_dh_N PF02771.16 ADV20532.1 - 3.6e-11 43.7 0.1 1.2e-10 42.0 0.0 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 ADV20532.1 - 2.8e-06 27.7 0.2 5.9e-06 26.6 0.2 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain NicO PF03824.16 ADV20533.1 - 4.1e-51 174.0 7.0 6.8e-50 170.0 0.3 2.5 2 1 0 2 2 2 2 High-affinity nickel-transport protein Sedlin_N PF04628.13 ADV20534.1 - 6.2e-13 49.0 0.0 8e-13 48.7 0.0 1.2 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region PTCB-BRCT PF12738.7 ADV20535.1 - 7.9e-33 112.2 0.0 1.6e-11 44.0 0.0 3.5 3 0 0 3 3 3 3 twin BRCT domain BRCT PF00533.26 ADV20535.1 - 2.4e-27 95.1 0.1 1.8e-11 44.3 0.0 4.2 4 0 0 4 4 4 3 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 ADV20535.1 - 2.6e-15 56.6 0.0 4.1e-05 23.9 0.0 4.8 4 0 0 4 4 4 4 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 ADV20535.1 - 4.9e-06 26.7 3.4 0.038 14.3 0.2 4.7 4 1 0 4 4 4 2 DNA ligase 3 BRCT domain BRCT_3 PF18428.1 ADV20535.1 - 0.0072 16.4 0.0 0.74 9.9 0.0 3.5 4 0 0 4 4 4 1 BRCA1 C Terminus (BRCT) domain RTT107_BRCT_5 PF16770.5 ADV20535.1 - 0.057 13.3 0.0 17 5.4 0.0 3.5 3 0 0 3 3 3 0 Regulator of Ty1 transposition protein 107 BRCT domain PIG-Y PF15159.6 ADV20537.1 - 1.3e-15 58.1 5.4 1.4e-15 57.9 5.4 1.1 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y DEAD PF00270.29 ADV20538.1 - 2.2e-19 69.9 0.0 4.3e-19 68.9 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ADV20538.1 - 4.3e-11 43.1 0.2 4.3e-10 39.9 0.0 2.7 3 0 0 3 3 3 1 Helicase conserved C-terminal domain RecQ_Zn_bind PF16124.5 ADV20538.1 - 1.7e-09 38.3 4.6 6.1e-09 36.5 2.5 2.8 2 0 0 2 2 2 1 RecQ zinc-binding Bac_luciferase PF00296.20 ADV20538.1 - 5.3e-05 22.8 0.0 0.00013 21.6 0.0 1.6 1 0 0 1 1 1 1 Luciferase-like monooxygenase ResIII PF04851.15 ADV20538.1 - 0.00042 20.4 0.0 0.00095 19.2 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Syntaxin_2 PF14523.6 ADV20540.1 - 3.5e-25 88.3 4.3 3.6e-24 85.1 0.3 2.7 2 1 0 3 3 3 1 Syntaxin-like protein SNARE PF05739.19 ADV20540.1 - 2.1e-10 40.5 0.7 2.1e-10 40.5 0.7 2.2 3 0 0 3 3 3 1 SNARE domain Syntaxin PF00804.25 ADV20540.1 - 2.8e-05 23.9 14.2 0.00011 22.0 11.1 2.2 1 1 1 2 2 2 1 Syntaxin DUF3924 PF13062.6 ADV20540.1 - 0.05 13.6 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3924) DUF1391 PF07151.12 ADV20540.1 - 0.07 13.0 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1391) PRKG1_interact PF15898.5 ADV20540.1 - 0.38 11.7 7.7 4.1 8.4 2.0 2.5 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain DUF1664 PF07889.12 ADV20540.1 - 1.2 9.2 8.4 0.72 9.9 2.4 3.0 2 2 1 3 3 3 0 Protein of unknown function (DUF1664) UCMA PF17085.5 ADV20540.1 - 1.5 8.9 7.6 0.11 12.5 1.9 2.0 2 0 0 2 2 2 0 Unique cartilage matrix associated protein UPF0242 PF06785.11 ADV20540.1 - 4.1 7.5 13.1 0.094 12.8 6.7 1.6 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus His_biosynth PF00977.21 ADV20541.1 - 3.1e-35 121.7 0.0 4e-35 121.3 0.0 1.1 1 0 0 1 1 1 1 Histidine biosynthesis protein eIF-3_zeta PF05091.12 ADV20542.1 - 8.5e-197 655.2 0.0 9.7e-197 655.1 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF3760 PF12586.8 ADV20544.1 - 2.9e-19 69.0 6.2 1.1e-18 67.1 6.3 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF3760) Vac_Fusion PF02346.16 ADV20544.1 - 0.089 12.4 0.1 0.25 11.0 0.1 1.8 1 0 0 1 1 1 0 Chordopoxvirus multifunctional envelope protein A27 Ku PF02735.16 ADV20545.1 - 1.6e-24 86.8 0.0 3.9e-24 85.5 0.0 1.6 1 1 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_PK_bind PF08785.11 ADV20545.1 - 9.1e-20 71.0 0.2 3e-19 69.3 0.2 1.9 1 0 0 1 1 1 1 Ku C terminal domain like Ku_N PF03731.15 ADV20545.1 - 9.6e-05 22.2 0.0 0.00028 20.7 0.0 1.7 1 1 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain Ku_C PF03730.14 ADV20545.1 - 0.044 14.5 0.3 0.044 14.5 0.3 3.7 5 0 0 5 5 5 0 Ku70/Ku80 C-terminal arm Erf4 PF10256.9 ADV20545.1 - 0.17 12.0 0.0 1.4 9.1 0.0 2.5 3 0 0 3 3 3 0 Golgin subfamily A member 7/ERF4 family CENP-B_dimeris PF09026.10 ADV20545.1 - 2 8.9 9.6 3.9 7.9 0.1 2.6 2 0 0 2 2 2 0 Centromere protein B dimerisation domain GEN1_C PF18380.1 ADV20547.1 - 4.1e-14 53.3 0.3 4.1e-14 53.3 0.3 2.7 3 0 0 3 3 3 1 Holliday junction resolvase Gen1 C-terminal domain XPG_N PF00752.17 ADV20547.1 - 7.1e-07 29.6 0.0 1.6e-06 28.5 0.0 1.6 1 0 0 1 1 1 1 XPG N-terminal domain Far-17a_AIG1 PF04750.14 ADV20548.1 - 1.8e-57 193.9 1.9 2.1e-57 193.7 1.9 1.0 1 0 0 1 1 1 1 FAR-17a/AIG1-like protein DUF1563 PF07599.11 ADV20548.1 - 0.054 13.6 0.1 0.12 12.4 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1563) DUF3464 PF11947.8 ADV20548.1 - 0.14 11.9 0.6 5.8 6.6 0.1 2.2 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 Maff2 PF12750.7 ADV20548.1 - 2.9 7.8 5.7 1.8 8.5 0.1 2.6 3 0 0 3 3 3 0 Maff2 family Topoisom_I_N PF02919.15 ADV20549.1 - 0.01 15.3 0.1 0.014 14.9 0.1 1.3 1 0 0 1 1 1 0 Eukaryotic DNA topoisomerase I, DNA binding fragment Molybdopterin PF00384.22 ADV20550.1 - 9.3e-66 222.5 0.0 8.8e-35 120.5 0.0 2.1 1 1 1 2 2 2 2 Molybdopterin oxidoreductase Fer2_4 PF13510.6 ADV20550.1 - 1.9e-19 69.5 0.4 4e-19 68.4 0.4 1.6 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain NADH-G_4Fe-4S_3 PF10588.9 ADV20550.1 - 4.5e-17 61.3 0.2 4.5e-17 61.3 0.2 2.1 2 0 0 2 2 2 1 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region NADH_dhqG_C PF09326.11 ADV20550.1 - 5.4e-15 55.8 0.0 1.2e-14 54.7 0.0 1.6 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit G, C-terminal Fer2 PF00111.27 ADV20550.1 - 6.1e-09 35.7 0.7 6.1e-09 35.7 0.7 2.0 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain TPP_enzyme_M PF00205.22 ADV20550.1 - 0.092 12.5 0.1 5 6.9 0.0 2.4 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain Fer4 PF00037.27 ADV20550.1 - 0.19 11.6 1.1 5.1 7.1 0.3 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain Pescadillo_N PF06732.11 ADV20551.1 - 7.7e-104 347.1 0.5 1.7e-103 345.9 0.0 1.7 2 0 0 2 2 2 1 Pescadillo N-terminus BRCT_2 PF16589.5 ADV20551.1 - 1e-08 35.5 0.0 2.3e-08 34.4 0.0 1.6 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 ADV20551.1 - 0.076 13.3 1.0 0.16 12.3 0.1 2.0 2 0 0 2 2 2 0 DNA ligase 3 BRCT domain Pro_isomerase PF00160.21 ADV20552.1 - 8e-47 159.4 0.2 9.1e-47 159.3 0.2 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Nucleoside_tran PF01733.18 ADV20553.1 - 9.6e-36 123.7 11.9 6.2e-32 111.2 1.9 2.2 1 1 0 2 2 2 2 Nucleoside transporter Peptidase_M50B PF13398.6 ADV20553.1 - 0.34 10.5 11.2 0.096 12.3 7.0 2.2 2 0 0 2 2 2 0 Peptidase M50B-like PDEase_I PF00233.19 ADV20554.1 - 5.2e-63 212.9 0.0 5.1e-62 209.7 0.0 2.0 1 1 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase zf-C3HC4_3 PF13920.6 ADV20556.1 - 7e-12 45.0 10.4 7e-12 45.0 10.4 2.7 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) FYVE PF01363.21 ADV20556.1 - 9.6e-08 32.1 0.2 9.6e-08 32.1 0.2 2.7 2 1 0 2 2 1 1 FYVE zinc finger Prok-RING_4 PF14447.6 ADV20556.1 - 9.8e-07 28.5 10.6 9.8e-07 28.5 10.6 2.7 3 0 0 3 3 3 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 ADV20556.1 - 4.9e-05 23.6 10.5 4.9e-05 23.6 10.5 2.6 2 0 0 2 2 2 1 Ring finger domain OrfB_Zn_ribbon PF07282.11 ADV20556.1 - 0.0074 16.2 6.0 0.55 10.2 1.9 3.1 3 0 0 3 3 3 2 Putative transposase DNA-binding domain zf-P11 PF03854.14 ADV20556.1 - 0.0078 15.9 6.3 0.0078 15.9 6.3 2.8 3 0 0 3 3 3 1 P-11 zinc finger C1_2 PF03107.16 ADV20556.1 - 0.026 14.9 3.3 0.026 14.9 3.3 2.5 2 1 1 3 3 2 0 C1 domain SAP PF02037.27 ADV20556.1 - 0.074 12.8 0.6 3.5 7.5 0.0 2.8 3 0 0 3 3 3 0 SAP domain FYVE_2 PF02318.16 ADV20556.1 - 0.11 12.7 0.4 0.11 12.7 0.4 3.2 3 0 0 3 3 3 0 FYVE-type zinc finger Ish1 PF10281.9 ADV20556.1 - 0.21 11.9 0.1 6.6 7.1 0.0 2.3 2 0 0 2 2 2 0 Putative stress-responsive nuclear envelope protein zf-RING_5 PF14634.6 ADV20556.1 - 0.3 11.1 22.0 0.16 11.9 1.5 2.7 3 0 0 3 3 3 0 zinc-RING finger domain DZR PF12773.7 ADV20556.1 - 0.78 9.8 17.9 0.3 11.1 0.8 3.7 3 1 1 4 4 4 0 Double zinc ribbon Ion_trans PF00520.31 ADV20557.1 - 6.7e-21 74.6 16.8 9.7e-21 74.1 16.8 1.1 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 ADV20557.1 - 1.3e-11 44.3 2.5 1.3e-11 44.3 2.5 2.9 3 1 0 3 3 3 1 Ion channel Torus PF16131.5 ADV20558.1 - 7.8e-09 36.2 21.6 0.007 17.1 0.6 5.1 2 1 3 5 5 5 4 Torus domain zf-CCCH PF00642.24 ADV20558.1 - 8e-09 35.2 25.7 0.0025 17.7 0.9 4.9 4 1 1 5 5 5 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 ADV20558.1 - 1.8e-07 30.8 1.5 1.8e-07 30.8 1.5 4.8 5 0 0 5 5 5 1 CCCH-type zinc finger zf-CCHC PF00098.23 ADV20558.1 - 5.8e-06 26.1 1.4 5.8e-06 26.1 1.4 2.4 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_2 PF13696.6 ADV20558.1 - 0.00066 19.4 1.4 0.0034 17.2 1.4 2.3 1 0 0 1 1 1 1 Zinc knuckle zf_CCCH_4 PF18345.1 ADV20558.1 - 0.0026 17.8 33.8 0.027 14.6 2.7 5.7 6 0 0 6 6 6 4 Zinc finger domain Utp12 PF04003.12 ADV20559.1 - 4.4e-20 72.0 0.0 7.8e-20 71.2 0.0 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family DUF5349 PF17298.2 ADV20559.1 - 0.073 12.8 5.0 0.36 10.5 0.0 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5349) SNF2_N PF00176.23 ADV20561.1 - 1.8e-56 191.4 0.9 2.7e-56 190.8 0.9 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ADV20561.1 - 1.6e-17 63.8 0.0 3.7e-17 62.6 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-RING_2 PF13639.6 ADV20561.1 - 4.2e-08 33.4 7.5 1.4e-07 31.7 7.5 2.0 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 ADV20561.1 - 5.4e-08 32.7 5.2 1.6e-07 31.2 4.7 2.2 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 ADV20561.1 - 1.2e-07 31.5 8.3 3.2e-07 30.1 8.3 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ADV20561.1 - 2.3e-07 30.6 8.2 5.8e-07 29.3 8.2 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) ResIII PF04851.15 ADV20561.1 - 4.5e-07 30.0 0.0 1.2e-06 28.7 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit zf-RING_5 PF14634.6 ADV20561.1 - 1.3e-06 28.2 8.1 3e-06 27.1 8.1 1.7 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 ADV20561.1 - 1.2e-05 25.0 7.2 6.4e-05 22.7 7.2 2.2 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 ADV20561.1 - 2.2e-05 24.2 5.7 2.2e-05 24.2 5.7 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) DEAD PF00270.29 ADV20561.1 - 0.00093 19.0 0.0 0.0026 17.5 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase HDA2-3 PF11496.8 ADV20561.1 - 0.016 14.4 1.4 0.036 13.2 0.3 2.1 2 1 0 2 2 2 0 Class II histone deacetylase complex subunits 2 and 3 WBS_methylT PF12589.8 ADV20561.1 - 0.19 12.5 2.1 0.67 10.8 2.1 2.0 1 0 0 1 1 1 0 Methyltransferase involved in Williams-Beuren syndrome zf-RING_4 PF14570.6 ADV20561.1 - 1.3 8.9 7.8 5.9 6.8 7.8 2.3 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_11 PF17123.5 ADV20561.1 - 3.5 7.4 9.7 9.7 6.0 9.7 1.8 1 0 0 1 1 1 0 RING-like zinc finger MR_MLE_C PF13378.6 ADV20562.1 - 5.2e-48 163.5 0.0 9.3e-47 159.4 0.0 2.3 1 1 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 ADV20562.1 - 2.1e-07 31.2 0.0 4.5e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain MAAL_C PF07476.11 ADV20562.1 - 0.07 12.3 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 Methylaspartate ammonia-lyase C-terminus RSN1_7TM PF02714.15 ADV20563.1 - 5.2e-65 219.5 16.1 5.2e-65 219.5 16.1 2.0 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate Anoctamin PF04547.12 ADV20563.1 - 0.00052 19.0 1.5 0.00052 19.0 1.5 2.6 2 1 1 3 3 3 1 Calcium-activated chloride channel DUF1129 PF06570.11 ADV20563.1 - 0.005 16.3 1.4 0.005 16.3 1.4 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1129) DUF2207 PF09972.9 ADV20563.1 - 0.049 12.4 3.0 0.55 8.9 0.0 2.6 2 1 0 2 2 2 0 Predicted membrane protein (DUF2207) Sensor PF13796.6 ADV20563.1 - 0.17 12.0 0.1 0.17 12.0 0.1 2.8 3 1 0 3 3 3 0 Putative sensor 2-oxoacid_dh PF00198.23 ADV20564.1 - 1.2e-81 273.6 0.2 1.6e-81 273.2 0.2 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 ADV20564.1 - 2.2e-19 69.1 2.0 4.5e-19 68.1 2.0 1.6 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 ADV20564.1 - 4.4e-08 32.8 0.2 0.00018 21.3 0.1 2.5 1 1 1 2 2 2 2 Biotin-lipoyl like HlyD_3 PF13437.6 ADV20564.1 - 3.8e-06 27.5 0.3 0.0064 17.2 0.0 2.6 1 1 1 2 2 2 2 HlyD family secretion protein GCV_H PF01597.19 ADV20564.1 - 0.00054 19.9 1.1 0.0012 18.7 0.3 2.0 2 0 0 2 2 2 1 Glycine cleavage H-protein RnfC_N PF13375.6 ADV20564.1 - 0.009 15.9 0.8 0.02 14.8 0.1 2.0 2 0 0 2 2 2 1 RnfC Barrel sandwich hybrid domain HlyD_D23 PF16576.5 ADV20564.1 - 0.082 12.1 0.1 0.082 12.1 0.1 2.2 2 1 0 2 2 2 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion Presenilin PF01080.17 ADV20564.1 - 0.7 8.6 8.2 1.3 7.7 8.2 1.4 1 0 0 1 1 1 0 Presenilin ECM1 PF05782.11 ADV20564.1 - 1.1 8.1 6.2 1.4 7.7 6.2 1.1 1 0 0 1 1 1 0 Extracellular matrix protein 1 (ECM1) SLC12 PF03522.15 ADV20564.1 - 8.4 5.3 7.3 1.6 7.7 3.9 1.4 2 0 0 2 2 2 0 Solute carrier family 12 RSN1_7TM PF02714.15 ADV20565.1 - 5.3e-79 265.4 23.5 1.5e-78 263.9 23.5 1.8 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 ADV20565.1 - 1.3e-36 125.7 1.3 6.4e-36 123.5 1.3 2.3 1 0 0 1 1 1 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 ADV20565.1 - 2.2e-28 99.7 0.0 5.6e-28 98.4 0.0 1.7 1 1 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter PHM7_ext PF12621.8 ADV20565.1 - 1.5e-12 47.5 0.0 3.1e-12 46.5 0.0 1.5 1 0 0 1 1 1 1 Extracellular tail, of 10TM putative phosphate transporter ubiquitin PF00240.23 ADV20568.1 - 3.5e-21 74.7 0.7 6e-21 74.0 0.5 1.5 2 0 0 2 2 2 1 Ubiquitin family Rad60-SLD PF11976.8 ADV20568.1 - 1.6e-11 43.8 0.3 6.3e-11 42.0 0.3 1.8 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like UBA PF00627.31 ADV20568.1 - 2.2e-08 33.9 0.1 2.2e-08 33.9 0.1 2.0 2 0 0 2 2 2 1 UBA/TS-N domain DUF2407 PF10302.9 ADV20568.1 - 2.8e-06 27.8 0.0 5e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain TBK1_ULD PF18396.1 ADV20568.1 - 0.00097 19.0 0.0 0.0017 18.3 0.0 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain STI1 PF17830.1 ADV20568.1 - 0.006 16.5 14.3 0.25 11.3 4.0 2.9 2 1 1 3 3 3 2 STI1 domain Ubiquitin_4 PF18036.1 ADV20568.1 - 0.0081 16.2 0.3 1.5 9.0 0.3 2.2 1 1 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 ADV20568.1 - 0.009 16.1 0.0 0.018 15.2 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 ADV20568.1 - 0.028 14.8 0.1 0.05 14.0 0.1 1.3 1 0 0 1 1 1 0 Ubiquitin-like domain GerD PF17898.1 ADV20568.1 - 0.031 14.2 5.1 0.054 13.4 5.1 1.3 1 0 0 1 1 1 0 Spore germination GerD central core domain Ubiquitin_2 PF14560.6 ADV20568.1 - 0.046 14.2 0.2 0.1 13.0 0.2 1.5 1 1 0 1 1 1 0 Ubiquitin-like domain Phage_tail_X PF05489.12 ADV20568.1 - 0.06 13.0 0.0 0.15 11.8 0.0 1.7 1 0 0 1 1 1 0 Phage Tail Protein X CUE PF02845.16 ADV20568.1 - 0.061 13.1 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 CUE domain RPN13_C PF16550.5 ADV20568.1 - 0.072 13.3 0.7 0.35 11.1 0.6 2.0 1 1 0 1 1 1 0 UCH-binding domain UN_NPL4 PF11543.8 ADV20568.1 - 0.082 13.4 0.1 0.14 12.7 0.1 1.3 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 ABC_membrane PF00664.23 ADV20569.1 - 4.5e-77 259.4 18.1 3.9e-44 151.4 3.1 3.1 3 0 0 3 3 3 3 ABC transporter transmembrane region ABC_tran PF00005.27 ADV20569.1 - 1.1e-63 213.8 0.0 5.9e-32 111.0 0.0 2.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 ADV20569.1 - 4.1e-15 55.8 1.7 8.1e-06 25.4 0.4 4.0 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 ADV20569.1 - 5.8e-09 36.6 0.4 0.0029 18.0 0.0 3.5 2 1 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 ADV20569.1 - 1.4e-08 34.3 0.2 0.0054 16.4 0.0 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain ABC_ATPase PF09818.9 ADV20569.1 - 1.9e-08 33.6 0.3 0.00025 20.0 0.0 3.3 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA_21 PF13304.6 ADV20569.1 - 2.5e-08 34.1 0.4 0.14 12.0 0.0 4.2 4 0 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 ADV20569.1 - 3.8e-08 33.7 1.1 0.03 14.6 0.1 4.0 2 2 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 ADV20569.1 - 8.7e-08 32.1 0.3 0.23 11.2 0.0 4.4 4 0 0 4 4 4 2 IstB-like ATP binding protein AAA_5 PF07728.14 ADV20569.1 - 6.1e-07 29.5 0.0 0.036 14.1 0.0 3.7 3 1 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 ADV20569.1 - 1e-06 28.6 0.6 0.011 15.4 0.0 3.6 2 1 0 2 2 2 2 AAA domain AAA_18 PF13238.6 ADV20569.1 - 1.6e-05 25.4 0.0 0.083 13.4 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_23 PF13476.6 ADV20569.1 - 8.1e-05 23.2 0.0 0.6 10.6 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.6 ADV20569.1 - 0.00024 21.3 0.0 0.58 10.3 0.0 3.0 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 ADV20569.1 - 0.00025 21.0 0.0 0.63 9.9 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_25 PF13481.6 ADV20569.1 - 0.00027 20.6 0.0 1.3 8.5 0.0 3.1 3 1 0 3 3 3 2 AAA domain DUF87 PF01935.17 ADV20569.1 - 0.00068 19.8 0.0 1 9.4 0.0 2.7 2 0 0 2 2 2 1 Helicase HerA, central domain AAA_15 PF13175.6 ADV20569.1 - 0.0013 18.5 0.0 0.28 10.9 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain APS_kinase PF01583.20 ADV20569.1 - 0.0018 18.2 0.0 1.7 8.5 0.0 2.6 2 0 0 2 2 2 1 Adenylylsulphate kinase Zeta_toxin PF06414.12 ADV20569.1 - 0.0018 17.6 0.0 2.1 7.5 0.0 2.6 2 0 0 2 2 2 2 Zeta toxin SbcCD_C PF13558.6 ADV20569.1 - 0.0024 18.0 3.6 1.7 8.9 0.1 4.2 3 2 0 3 3 3 1 Putative exonuclease SbcCD, C subunit G-alpha PF00503.20 ADV20569.1 - 0.0029 16.8 0.0 1 8.5 0.0 2.3 2 0 0 2 2 2 1 G-protein alpha subunit AAA_24 PF13479.6 ADV20569.1 - 0.0067 16.2 0.0 1.6 8.4 0.0 2.4 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 ADV20569.1 - 0.007 16.3 0.0 2.7 7.9 0.0 2.7 2 0 0 2 2 2 1 NACHT domain AAA_28 PF13521.6 ADV20569.1 - 0.008 16.4 1.8 6.2 7.0 0.0 3.7 3 1 0 4 4 3 0 AAA domain RNA_helicase PF00910.22 ADV20569.1 - 0.0089 16.4 0.0 8.9 6.8 0.0 3.0 3 0 0 3 3 2 0 RNA helicase CPT PF07931.12 ADV20569.1 - 0.013 15.4 0.1 1.4 8.7 0.0 2.9 3 0 0 3 3 3 0 Chloramphenicol phosphotransferase-like protein NB-ARC PF00931.22 ADV20569.1 - 0.022 14.0 0.0 6.3 5.9 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain AAA_17 PF13207.6 ADV20569.1 - 0.024 15.1 0.3 12 6.3 0.1 2.9 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 ADV20569.1 - 0.025 14.1 0.0 6.2 6.3 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region DUF3987 PF13148.6 ADV20569.1 - 0.026 13.6 2.6 1.4 7.8 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3987) Sigma54_activat PF00158.26 ADV20569.1 - 0.032 14.0 0.0 3.1 7.5 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain Cytidylate_kin PF02224.18 ADV20569.1 - 0.033 13.9 0.1 1 9.0 0.0 2.4 2 0 0 2 2 2 0 Cytidylate kinase Sigma54_activ_2 PF14532.6 ADV20569.1 - 0.045 13.9 0.0 9.7 6.3 0.0 2.8 2 0 0 2 2 2 0 Sigma-54 interaction domain Mg_chelatase PF01078.21 ADV20569.1 - 0.057 12.8 0.1 12 5.2 0.0 2.5 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA PF00004.29 ADV20569.1 - 0.062 13.7 0.4 36 4.8 0.0 3.8 2 2 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) PRK PF00485.18 ADV20569.1 - 0.063 13.0 0.0 9.1 6.0 0.0 2.4 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family FtsK_SpoIIIE PF01580.18 ADV20569.1 - 0.11 11.9 0.0 6.8 6.0 0.0 2.7 2 0 0 2 2 2 0 FtsK/SpoIIIE family ATP-synt_ab PF00006.25 ADV20569.1 - 0.14 11.8 0.0 4.1 7.0 0.0 2.4 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain DUF2075 PF09848.9 ADV20569.1 - 0.19 10.9 0.5 18 4.4 0.6 2.9 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) CbiA PF01656.23 ADV20569.1 - 0.19 11.8 0.1 23 5.0 0.0 2.5 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain ATPase PF06745.13 ADV20569.1 - 1.1 8.5 3.4 6.7 6.0 0.1 2.7 3 0 0 3 3 3 0 KaiC DEAD PF00270.29 ADV20570.1 - 1.6e-43 148.5 0.6 2.5e-43 147.9 0.1 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ADV20570.1 - 8e-24 84.1 0.0 3.2e-23 82.2 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 ADV20570.1 - 2e-18 66.4 0.2 3.4e-18 65.6 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 ADV20570.1 - 0.00087 19.3 0.0 0.0019 18.2 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit GTP_EFTU PF00009.27 ADV20571.1 - 1.1e-33 116.5 0.0 5e-33 114.3 0.0 2.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 ADV20571.1 - 6.7e-18 64.7 0.0 1.7e-17 63.4 0.0 1.7 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.25 ADV20571.1 - 2.7e-10 40.5 0.2 2.7e-10 40.5 0.2 4.0 4 0 0 4 4 4 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 ADV20571.1 - 3.8e-06 27.0 0.3 2.8e-05 24.2 0.0 2.7 3 0 0 3 3 3 1 50S ribosome-binding GTPase Roc PF08477.13 ADV20571.1 - 8.9e-05 22.7 0.0 0.00023 21.4 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU_D4 PF14578.6 ADV20571.1 - 0.0054 16.6 0.3 0.018 14.9 0.3 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 4 Ras PF00071.22 ADV20571.1 - 0.018 14.6 0.3 0.12 12.0 0.0 2.6 2 1 0 2 2 2 0 Ras family ATP_bind_1 PF03029.17 ADV20571.1 - 0.082 12.7 0.0 0.21 11.3 0.0 1.8 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein Atg14 PF10186.9 ADV20572.1 - 2.3e-08 33.5 0.5 7e-08 31.9 0.4 1.7 1 1 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 ATG16 PF08614.11 ADV20572.1 - 0.022 15.0 3.1 0.058 13.6 3.1 1.7 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) IFT57 PF10498.9 ADV20572.1 - 0.067 12.1 3.6 0.1 11.5 3.6 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 MscS_porin PF12795.7 ADV20572.1 - 0.077 12.5 4.9 0.13 11.8 4.9 1.3 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain mRNA_cap_enzyme PF01331.19 ADV20573.1 - 5.2e-48 163.5 0.0 8.1e-48 162.8 0.0 1.3 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.15 ADV20573.1 - 1e-30 106.5 0.1 1.8e-30 105.8 0.1 1.4 1 0 0 1 1 1 1 mRNA capping enzyme, C-terminal domain DNA_ligase_A_M PF01068.21 ADV20573.1 - 3.7e-08 33.3 0.0 0.00039 20.1 0.0 2.6 1 1 1 2 2 2 2 ATP dependent DNA ligase domain RNA_ligase PF09414.10 ADV20573.1 - 0.00026 21.3 0.2 0.0007 19.9 0.1 1.7 2 0 0 2 2 2 1 RNA ligase Nup96 PF12110.8 ADV20574.1 - 5e-92 308.1 0.0 6.7e-92 307.7 0.0 1.2 1 0 0 1 1 1 1 Nuclear protein 96 Nucleoporin2 PF04096.14 ADV20574.1 - 3.1e-48 163.7 0.0 5.4e-48 162.9 0.0 1.4 1 0 0 1 1 1 1 Nucleoporin autopeptidase Nucleoporin_FG PF13634.6 ADV20574.1 - 2.2e-30 105.3 347.0 8e-08 33.0 35.3 11.2 3 2 9 12 12 12 10 Nucleoporin FG repeat region Thr_synth_N PF14821.6 ADV20575.1 - 2e-27 95.2 0.0 4.6e-27 94.1 0.0 1.6 1 0 0 1 1 1 1 Threonine synthase N terminus PALP PF00291.25 ADV20575.1 - 2.8e-15 56.5 0.0 9.2e-14 51.5 0.0 2.2 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme KA1 PF02149.19 ADV20575.1 - 0.072 12.9 0.0 0.22 11.4 0.0 1.8 1 0 0 1 1 1 0 Kinase associated domain 1 ADH_zinc_N PF00107.26 ADV20578.1 - 6.6e-20 71.4 0.1 1.6e-19 70.2 0.0 1.7 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ADV20578.1 - 9.8e-11 42.8 0.1 1.8e-10 42.0 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ADV20578.1 - 8.9e-05 22.3 0.0 0.00029 20.7 0.0 1.9 2 1 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_N_2 PF16884.5 ADV20578.1 - 0.022 14.7 0.0 0.062 13.2 0.0 1.9 1 0 0 1 1 1 0 N-terminal domain of oxidoreductase OrfB_Zn_ribbon PF07282.11 ADV20579.1 - 0.59 10.1 3.9 1.2 9.1 0.4 2.5 2 0 0 2 2 2 0 Putative transposase DNA-binding domain adh_short PF00106.25 ADV20580.1 - 3.4e-46 157.2 1.0 4.9e-46 156.7 1.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ADV20580.1 - 6.5e-26 91.3 1.2 8.7e-26 90.9 1.2 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ADV20580.1 - 1.5e-09 38.0 0.6 2.3e-09 37.4 0.6 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_4 PF07993.12 ADV20580.1 - 0.0027 16.9 0.3 0.004 16.4 0.3 1.3 1 0 0 1 1 1 1 Male sterility protein 2-Hacid_dh_C PF02826.19 ADV20580.1 - 0.011 15.1 0.1 0.016 14.6 0.1 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 ADV20580.1 - 0.016 15.1 0.3 0.029 14.3 0.3 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.14 ADV20580.1 - 0.018 14.3 1.2 0.027 13.7 1.2 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Epimerase PF01370.21 ADV20580.1 - 0.033 13.6 0.2 0.048 13.1 0.2 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family THF_DHG_CYH_C PF02882.19 ADV20580.1 - 0.044 13.1 0.1 0.083 12.2 0.1 1.5 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain NAD_binding_7 PF13241.6 ADV20580.1 - 0.069 13.6 1.0 0.17 12.3 1.0 2.0 1 1 0 1 1 1 0 Putative NAD(P)-binding Polysacc_synt_2 PF02719.15 ADV20580.1 - 0.085 12.0 0.5 0.1 11.7 0.5 1.3 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 ADV20580.1 - 0.096 12.1 0.1 0.13 11.6 0.1 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase TF_Zn_Ribbon PF08271.12 ADV20581.1 - 0.0065 16.0 0.0 0.014 14.9 0.0 1.5 1 0 0 1 1 1 1 TFIIB zinc-binding WD40_4 PF16300.5 ADV20582.1 - 7.1e-31 105.8 0.4 4.2e-14 52.2 0.2 2.9 2 0 0 2 2 2 2 Type of WD40 repeat WD40 PF00400.32 ADV20582.1 - 7.8e-06 26.5 1.7 1.4 9.9 0.0 5.6 5 0 0 5 5 4 1 WD domain, G-beta repeat DUF1899 PF08953.11 ADV20582.1 - 4.7e-05 23.2 0.0 0.23 11.4 0.0 2.6 2 0 0 2 2 2 2 Domain of unknown function (DUF1899) Zeta_toxin PF06414.12 ADV20582.1 - 0.0001 21.6 0.0 0.00019 20.8 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin PQQ_3 PF13570.6 ADV20582.1 - 0.0016 18.9 6.2 0.074 13.6 0.1 4.4 4 0 0 4 4 4 1 PQQ-like domain ANAPC4_WD40 PF12894.7 ADV20582.1 - 0.0022 18.2 0.0 0.58 10.5 0.0 3.5 2 1 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain KAP_NTPase PF07693.14 ADV20582.1 - 0.0082 15.4 0.0 0.016 14.5 0.0 1.3 1 0 0 1 1 1 1 KAP family P-loop domain cobW PF02492.19 ADV20582.1 - 0.014 15.0 0.0 0.028 14.0 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 ADV20582.1 - 0.016 15.1 0.3 0.041 13.8 0.3 1.7 1 0 0 1 1 1 0 NACHT domain Frtz PF11768.8 ADV20582.1 - 0.022 13.1 0.0 0.037 12.3 0.0 1.2 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz NB-ARC PF00931.22 ADV20582.1 - 0.023 13.9 0.0 0.038 13.2 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain PQQ_2 PF13360.6 ADV20582.1 - 0.024 14.2 0.1 0.055 13.0 0.1 1.5 1 0 0 1 1 1 0 PQQ-like domain AAA PF00004.29 ADV20582.1 - 0.026 15.0 0.0 0.059 13.8 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) SRP54 PF00448.22 ADV20582.1 - 0.028 14.1 0.0 0.065 12.9 0.0 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain ABC_tran PF00005.27 ADV20582.1 - 0.034 14.7 0.0 0.16 12.5 0.0 2.1 2 0 0 2 2 2 0 ABC transporter AAA_16 PF13191.6 ADV20582.1 - 0.046 14.1 0.0 0.11 12.9 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain AAA_18 PF13238.6 ADV20582.1 - 0.075 13.6 0.0 0.15 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain ResIII PF04851.15 ADV20582.1 - 0.1 12.6 0.0 0.19 11.7 0.0 1.4 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_14 PF13173.6 ADV20582.1 - 0.13 12.3 0.0 0.3 11.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain WDCP PF15390.6 ADV20582.1 - 0.19 10.1 0.3 0.5 8.7 0.0 1.8 2 0 0 2 2 2 0 WD repeat and coiled-coil-containing protein family MeaB PF03308.16 ADV20582.1 - 0.2 10.6 0.0 0.33 9.9 0.0 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB TsaE PF02367.17 ADV20582.1 - 0.2 11.7 0.0 0.39 10.7 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Pro_isomerase PF00160.21 ADV20583.1 - 3e-45 154.3 0.1 3.5e-45 154.1 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Sec1 PF00995.23 ADV20584.1 - 4.6e-116 389.4 0.0 5.8e-116 389.0 0.0 1.0 1 0 0 1 1 1 1 Sec1 family MAPEG PF01124.18 ADV20585.1 - 6.8e-17 61.6 0.1 8.1e-17 61.3 0.1 1.0 1 0 0 1 1 1 1 MAPEG family RNA_pol_I_A49 PF06870.12 ADV20586.1 - 1e-90 304.4 0.4 1.2e-90 304.2 0.4 1.0 1 0 0 1 1 1 1 A49-like RNA polymerase I associated factor RNA_pol_L_2 PF13656.6 ADV20587.1 - 6.5e-29 99.5 0.0 9.2e-29 99.0 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 ADV20587.1 - 8.3e-10 38.0 0.0 1.3e-09 37.4 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Imm5 PF14423.6 ADV20587.1 - 0.11 12.7 0.3 0.19 11.9 0.3 1.3 1 0 0 1 1 1 0 Immunity protein Imm5 Het-C PF07217.11 ADV20588.1 - 4.4e-225 748.5 0.0 5.6e-225 748.1 0.0 1.1 1 0 0 1 1 1 1 Heterokaryon incompatibility protein Het-C CBFD_NFYB_HMF PF00808.23 ADV20588.1 - 0.19 12.1 0.0 0.93 9.8 0.0 2.0 2 0 0 2 2 2 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CUE PF02845.16 ADV20589.1 - 2.2e-11 43.2 0.1 3.5e-11 42.6 0.1 1.3 1 0 0 1 1 1 1 CUE domain Rhomboid PF01694.22 ADV20589.1 - 1.7e-07 31.3 7.1 1.7e-07 31.3 7.1 1.8 2 0 0 2 2 2 1 Rhomboid family DUF1751 PF08551.10 ADV20589.1 - 1.2e-05 25.8 0.1 2.6e-05 24.7 0.1 1.5 1 0 0 1 1 1 1 Eukaryotic integral membrane protein (DUF1751) DER1 PF04511.15 ADV20589.1 - 5.6e-05 23.2 7.4 0.00025 21.1 7.4 1.8 1 1 0 1 1 1 1 Der1-like family E3_UbLigase_EDD PF11547.8 ADV20589.1 - 0.034 13.9 0.1 0.056 13.2 0.1 1.3 1 0 0 1 1 1 0 E3 ubiquitin ligase EDD CE2_N PF17996.1 ADV20590.1 - 0.012 15.6 0.0 0.024 14.6 0.0 1.4 1 0 0 1 1 1 0 Carbohydrate esterase 2 N-terminal WD40 PF00400.32 ADV20591.1 - 1.6e-10 41.4 14.4 1.2e-05 26.0 0.4 6.8 5 1 0 5 5 5 4 WD domain, G-beta repeat Glyco_transf_24 PF18404.1 ADV20593.1 - 2.6e-142 473.0 3.8 5.1e-142 472.0 3.8 1.5 1 0 0 1 1 1 1 Glucosyltransferase 24 Thioredoxin_14 PF18402.1 ADV20593.1 - 8.8e-59 199.5 0.0 4.1e-58 197.3 0.0 2.1 2 0 0 2 2 2 1 Thioredoxin-like domain UDP-g_GGTase PF06427.11 ADV20593.1 - 3.6e-36 123.6 0.0 6.8e-36 122.7 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose:Glycoprotein Glucosyltransferase Thioredoxin_13 PF18401.1 ADV20593.1 - 1.1e-29 103.0 0.0 2.8e-29 101.8 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_15 PF18403.1 ADV20593.1 - 8.5e-28 97.7 0.0 4.9e-25 88.7 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_12 PF18400.1 ADV20593.1 - 9.3e-19 68.0 8.5 1.2e-13 51.3 1.4 2.5 1 1 1 2 2 2 2 Thioredoxin-like domain Glyco_transf_8 PF01501.20 ADV20593.1 - 2.2e-07 30.7 0.0 4e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 8 Hexapep_2 PF14602.6 ADV20596.1 - 7.1e-12 44.9 6.8 4.5e-06 26.3 2.2 2.5 2 0 0 2 2 2 2 Hexapeptide repeat of succinyl-transferase Hexapep PF00132.24 ADV20596.1 - 7.3e-11 41.4 8.1 0.0015 18.2 0.0 3.9 4 0 0 4 4 4 3 Bacterial transferase hexapeptide (six repeats) Mcp5_PH PF12814.7 ADV20597.1 - 4.9e-47 159.0 0.4 1.3e-46 157.7 0.4 1.8 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology PH PF00169.29 ADV20597.1 - 1.6e-06 28.6 0.0 3e-06 27.7 0.0 1.5 1 0 0 1 1 1 1 PH domain DivIVA PF05103.13 ADV20597.1 - 0.53 10.4 33.0 0.018 15.1 12.1 5.3 2 1 2 4 4 4 0 DivIVA protein MCC-bdg_PDZ PF10506.9 ADV20597.1 - 0.95 9.5 9.8 0.45 10.6 3.5 3.0 2 1 1 3 3 3 0 PDZ domain of MCC-2 bdg protein for Usher syndrome IMCp PF12314.8 ADV20597.1 - 8.4 6.8 517.0 0.25 11.7 52.5 14.9 1 1 15 16 16 16 0 Inner membrane complex protein Lip_prot_lig_C PF10437.9 ADV20599.1 - 0.12 12.4 0.0 0.43 10.6 0.0 1.9 2 0 0 2 2 2 0 Bacterial lipoate protein ligase C-terminus YL1_C PF08265.11 ADV20599.1 - 0.23 11.3 0.7 27 4.6 0.0 3.2 4 0 0 4 4 4 0 YL1 nuclear protein C-terminal domain DUF1770 PF08589.10 ADV20600.1 - 0.054 14.5 1.1 0.054 14.5 1.1 1.9 2 0 0 2 2 2 0 Fungal protein of unknown function (DUF1770) FMN_dh PF01070.18 ADV20601.1 - 1.3e-130 435.5 0.0 1.8e-130 435.0 0.0 1.2 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 ADV20601.1 - 1.1e-14 54.4 0.0 2.3e-14 53.3 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain ThiG PF05690.14 ADV20601.1 - 0.0098 15.2 0.0 2.2 7.5 0.0 2.4 2 0 0 2 2 2 2 Thiazole biosynthesis protein ThiG Glu_synthase PF01645.17 ADV20601.1 - 0.011 14.9 0.1 0.053 12.7 0.0 1.9 2 0 0 2 2 2 0 Conserved region in glutamate synthase IMPDH PF00478.25 ADV20601.1 - 0.012 14.7 0.2 0.061 12.3 0.2 2.1 2 1 0 2 2 2 0 IMP dehydrogenase / GMP reductase domain NMO PF03060.15 ADV20601.1 - 0.053 12.9 1.0 0.27 10.6 0.5 2.2 2 0 0 2 2 2 0 Nitronate monooxygenase OB_NTP_bind PF07717.16 ADV20602.1 - 5.2e-20 71.6 0.0 2.1e-19 69.7 0.0 2.1 2 0 0 2 2 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 ADV20602.1 - 1.8e-19 70.0 0.1 3.6e-19 69.0 0.1 1.5 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 ADV20602.1 - 1.5e-12 47.8 0.0 6e-12 45.9 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 ADV20602.1 - 2.5e-06 27.8 0.0 5.6e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain DEAD PF00270.29 ADV20602.1 - 3.2e-05 23.8 0.0 7.6e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_19 PF13245.6 ADV20602.1 - 0.0005 20.4 0.0 0.0012 19.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 ADV20602.1 - 0.012 15.4 0.0 0.022 14.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 ADV20602.1 - 0.014 14.5 0.1 0.045 12.8 0.0 1.8 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_14 PF13173.6 ADV20602.1 - 0.069 13.2 0.0 2.9 7.9 0.0 2.4 1 1 0 1 1 1 0 AAA domain SRP54 PF00448.22 ADV20602.1 - 0.091 12.4 0.0 0.26 10.9 0.0 1.9 2 1 0 2 2 2 0 SRP54-type protein, GTPase domain Zeta_toxin PF06414.12 ADV20602.1 - 0.1 11.9 0.5 0.59 9.4 0.1 2.2 1 1 1 2 2 2 0 Zeta toxin DUF2075 PF09848.9 ADV20602.1 - 0.12 11.6 0.0 0.2 10.8 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Helicase_RecD PF05127.14 ADV20602.1 - 0.12 12.2 0.1 0.39 10.6 0.0 1.9 2 0 0 2 2 2 0 Helicase AAA_29 PF13555.6 ADV20602.1 - 0.16 11.7 0.0 0.38 10.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain MOR2-PAG1_N PF14222.6 ADV20604.1 - 2.4e-119 399.8 0.0 9e-119 397.9 0.0 1.9 2 0 0 2 2 2 1 Cell morphogenesis N-terminal MOR2-PAG1_C PF14225.6 ADV20604.1 - 3.7e-77 259.6 0.2 3.7e-77 259.6 0.2 2.9 4 0 0 4 4 4 1 Cell morphogenesis C-terminal MOR2-PAG1_mid PF14228.6 ADV20604.1 - 4.5e-22 77.6 0.0 4.5e-14 51.1 0.0 4.2 4 1 0 4 4 4 3 Cell morphogenesis central region HEAT_2 PF13646.6 ADV20604.1 - 0.14 12.6 2.2 0.69 10.3 0.0 3.4 4 0 0 4 4 4 0 HEAT repeats dCMP_cyt_deam_1 PF00383.23 ADV20605.1 - 7.6e-25 86.7 0.7 1.1e-24 86.2 0.7 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 ADV20605.1 - 5.5e-11 42.4 0.1 8.6e-11 41.7 0.1 1.2 1 0 0 1 1 1 1 MafB19-like deaminase AAA_18 PF13238.6 ADV20605.1 - 0.00063 20.3 0.2 0.0096 16.5 0.0 2.5 1 1 1 2 2 2 1 AAA domain AAA_17 PF13207.6 ADV20605.1 - 0.0027 18.1 0.1 0.0068 16.8 0.1 1.6 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 ADV20605.1 - 0.025 14.8 0.1 0.14 12.4 0.0 2.2 3 0 0 3 3 3 0 AAA domain ADK PF00406.22 ADV20605.1 - 0.14 12.2 0.0 0.25 11.4 0.0 1.3 1 0 0 1 1 1 0 Adenylate kinase SRPRB PF09439.10 ADV20606.1 - 1.3e-18 67.0 0.0 2.4e-18 66.2 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 ADV20606.1 - 4.8e-07 29.9 0.0 7.6e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ADV20606.1 - 5.9e-07 29.1 0.0 7.9e-07 28.7 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Roc PF08477.13 ADV20606.1 - 1e-06 28.9 0.0 1.6e-06 28.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ADV20606.1 - 2.7e-06 27.0 0.0 4.1e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ADV20606.1 - 1.8e-05 24.4 0.3 0.0014 18.2 0.1 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Ras PF00071.22 ADV20606.1 - 0.00014 21.5 0.0 0.00019 21.1 0.0 1.2 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 ADV20606.1 - 0.00039 19.7 0.0 0.45 9.6 0.0 2.1 1 1 1 2 2 2 2 G-protein alpha subunit FeoB_N PF02421.18 ADV20606.1 - 0.073 12.6 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 Ferrous iron transport protein B Atrophin-1 PF03154.15 ADV20606.1 - 3.4 5.8 6.4 4.6 5.4 6.4 1.1 1 0 0 1 1 1 0 Atrophin-1 family Pmp3 PF01679.17 ADV20607.1 - 7.3e-24 83.7 11.8 8.9e-24 83.4 11.8 1.1 1 0 0 1 1 1 1 Proteolipid membrane potential modulator DUF4730 PF15873.5 ADV20607.1 - 0.17 12.1 2.5 0.24 11.7 2.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4730) EMP24_GP25L PF01105.24 ADV20608.1 - 1.3e-40 139.3 0.0 1.5e-40 139.1 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Trimer_CC PF08954.11 ADV20608.1 - 0.064 12.8 0.3 0.11 12.0 0.3 1.4 1 0 0 1 1 1 0 Trimerisation motif Ion_trans_N PF08412.10 ADV20609.1 - 1.6 8.4 4.0 12 5.5 0.5 2.4 2 0 0 2 2 2 0 Ion transport protein N-terminal TRAM_LAG1_CLN8 PF03798.16 ADV20610.1 - 8.2e-43 146.5 18.9 8.2e-43 146.5 18.9 1.7 2 0 0 2 2 2 1 TLC domain TRAM1 PF08390.11 ADV20610.1 - 9e-17 60.5 0.2 9e-17 60.5 0.2 3.1 3 0 0 3 3 3 1 TRAM1-like protein DUF765 PF05570.11 ADV20610.1 - 0.04 14.1 0.1 0.086 13.0 0.1 1.6 1 0 0 1 1 1 0 Circovirus protein of unknown function (DUF765) DDE_1 PF03184.19 ADV20611.1 - 1.5e-20 73.6 0.0 2.2e-20 73.0 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_psq PF05225.16 ADV20611.1 - 0.0001 22.0 0.0 0.00038 20.1 0.0 2.0 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.16 ADV20611.1 - 0.0048 16.9 0.0 0.016 15.2 0.0 2.0 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DDE_3 PF13358.6 ADV20611.1 - 0.013 15.2 0.0 0.051 13.3 0.0 1.9 2 0 0 2 2 2 0 DDE superfamily endonuclease HTH_23 PF13384.6 ADV20611.1 - 0.036 13.9 0.0 0.17 11.7 0.0 2.2 1 0 0 1 1 1 0 Homeodomain-like domain HTH_7 PF02796.15 ADV20611.1 - 0.052 13.6 0.0 0.59 10.2 0.0 2.7 3 0 0 3 3 3 0 Helix-turn-helix domain of resolvase Ank_2 PF12796.7 ADV20612.1 - 1.3e-16 61.0 0.4 1.1e-07 32.3 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ADV20612.1 - 2.7e-15 56.5 0.8 1.1e-06 29.0 0.0 3.9 2 2 2 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 ADV20612.1 - 8.8e-14 51.2 0.1 2.3e-06 27.8 0.1 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 ADV20612.1 - 2.2e-12 46.9 0.2 0.00012 22.3 0.1 2.6 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ADV20612.1 - 8.6e-11 41.1 0.5 0.0013 19.1 0.0 3.7 4 0 0 4 4 4 2 Ankyrin repeat KilA-N PF04383.13 ADV20612.1 - 0.00025 20.9 0.1 0.0026 17.6 0.1 2.3 1 1 0 1 1 1 1 KilA-N domain DUF3122 PF11320.8 ADV20612.1 - 0.13 12.4 0.0 0.26 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3122) Fez1 PF06818.15 ADV20612.1 - 2.7 8.4 12.3 0.6 10.5 8.5 1.8 2 0 0 2 2 2 0 Fez1 CybS PF05328.12 ADV20613.1 - 2.2e-46 156.9 0.0 2.5e-46 156.6 0.0 1.1 1 0 0 1 1 1 1 CybS, succinate dehydrogenase cytochrome B small subunit DNA_pol_D_N PF18018.1 ADV20614.1 - 1.1e-39 135.5 0.0 1.6e-39 134.9 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase delta subunit OB-fold domain DNA_pol_E_B PF04042.16 ADV20614.1 - 2.1e-33 115.4 0.0 2.9e-33 115.0 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Rad52_Rad22 PF04098.15 ADV20615.1 - 2.8e-54 183.2 0.0 5.2e-54 182.3 0.0 1.5 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein RNA_pol_Rpb4 PF03874.16 ADV20617.1 - 4.2e-12 46.5 0.1 6.8e-12 45.8 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb4 Fungal_trans PF04082.18 ADV20618.1 - 3.5e-10 39.3 0.1 6.4e-10 38.5 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ADV20618.1 - 7.5e-09 35.6 9.2 1.4e-08 34.7 9.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PSI_integrin PF17205.3 ADV20618.1 - 0.0049 16.6 2.1 0.015 15.1 2.1 1.8 1 0 0 1 1 1 1 Integrin plexin domain RRM_1 PF00076.22 ADV20620.1 - 4.8e-13 48.7 0.1 1.4e-12 47.2 0.1 1.7 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ADV20620.1 - 0.062 12.9 0.0 0.096 12.3 0.0 1.2 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) tRNA-synt_1e PF01406.19 ADV20621.1 - 2.5e-122 408.0 0.0 4.1e-122 407.3 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 ADV20621.1 - 2.5e-08 33.1 0.2 0.00011 21.1 0.1 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (M) DALR_2 PF09190.11 ADV20621.1 - 3.4e-05 24.2 0.9 0.00011 22.7 0.0 2.3 3 0 0 3 3 3 1 DALR domain tRNA-synt_1f PF01921.18 ADV20621.1 - 0.0002 20.4 0.9 0.62 8.9 0.0 3.0 2 1 0 2 2 2 2 tRNA synthetases class I (K) tRNA-synt_1 PF00133.22 ADV20621.1 - 0.00065 18.1 0.4 0.0069 14.7 0.0 2.3 3 0 0 3 3 3 1 tRNA synthetases class I (I, L, M and V) Cofilin_ADF PF00241.20 ADV20622.1 - 4.4e-22 78.1 0.1 5e-22 78.0 0.1 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein HEAT PF02985.22 ADV20623.1 - 0.0046 17.1 5.0 0.85 10.0 0.0 5.2 5 0 0 5 5 5 1 HEAT repeat RTP1_C1 PF10363.9 ADV20623.1 - 0.11 12.6 8.1 0.35 11.1 0.0 4.9 6 2 0 6 6 6 0 Required for nuclear transport of RNA pol II C-terminus 1 PET117 PF15786.5 ADV20624.1 - 9e-27 93.2 0.0 1.8e-26 92.2 0.0 1.5 1 1 0 1 1 1 1 PET assembly of cytochrome c oxidase, mitochondrial WD40 PF00400.32 ADV20625.1 - 8.3e-14 51.8 0.2 1.7e-05 25.5 0.0 4.4 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV20625.1 - 4.7e-08 33.2 0.1 0.0021 18.3 0.0 3.4 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain RPN7 PF10602.9 ADV20626.1 - 0.0041 16.8 0.0 0.36 10.5 0.0 3.3 3 0 0 3 3 3 1 26S proteasome subunit RPN7 TPR_2 PF07719.17 ADV20626.1 - 0.024 14.7 4.3 14 6.1 0.0 5.4 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_8 PF13181.6 ADV20626.1 - 0.42 10.9 3.3 66 4.1 0.0 5.2 6 0 0 6 6 6 0 Tetratricopeptide repeat Peptidase_C50 PF03568.17 ADV20627.1 - 4.8e-140 467.2 0.0 6.7e-140 466.7 0.0 1.2 1 0 0 1 1 1 1 Peptidase family C50 CHAT PF12770.7 ADV20627.1 - 1.5e-05 24.6 0.2 0.0013 18.3 0.0 2.6 2 1 0 2 2 2 1 CHAT domain Exo70 PF03081.15 ADV20628.1 - 4.6e-43 147.7 0.0 8e-43 146.9 0.0 1.3 1 0 0 1 1 1 1 Exo70 exocyst complex subunit COG6 PF06419.11 ADV20628.1 - 0.01 14.1 0.0 0.019 13.2 0.0 1.5 1 0 0 1 1 1 0 Conserved oligomeric complex COG6 Aminotran_3 PF00202.21 ADV20629.1 - 6.5e-36 123.9 0.0 4.3e-17 61.9 0.0 3.3 3 0 0 3 3 3 3 Aminotransferase class-III AAA_26 PF13500.6 ADV20629.1 - 1.1e-13 51.4 0.0 3.2e-13 50.0 0.0 1.7 2 0 0 2 2 2 1 AAA domain FCH PF00611.23 ADV20630.1 - 4e-15 55.8 2.0 5.3e-15 55.5 0.2 2.2 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_1 PF00018.28 ADV20630.1 - 6.3e-10 38.5 0.1 1.3e-09 37.5 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ADV20630.1 - 3e-08 33.4 0.0 5.6e-08 32.5 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 ADV20630.1 - 6e-05 22.6 0.0 0.00014 21.5 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain DHC_N1 PF08385.12 ADV20630.1 - 0.0059 15.3 0.7 0.0097 14.6 0.7 1.3 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 1 CEP209_CC5 PF16574.5 ADV20630.1 - 2.4 8.4 6.9 5.9 7.1 6.9 1.6 1 0 0 1 1 1 0 Coiled-coil region of centrosome protein CE290 zf-C2H2_2 PF12756.7 ADV20631.1 - 1.4e-37 128.1 3.0 1.4e-28 99.2 0.0 3.2 2 1 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 ADV20631.1 - 8.4e-13 48.2 7.2 3e-09 36.9 1.8 3.5 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 ADV20631.1 - 1.6e-08 34.7 1.9 1.6e-08 34.7 1.9 2.2 3 0 0 3 3 2 1 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 ADV20631.1 - 4.2e-06 27.1 7.3 0.1 13.5 0.2 4.5 4 0 0 4 4 4 1 C2H2-type zinc finger zf-LYAR PF08790.11 ADV20631.1 - 0.0044 16.9 2.1 1.1 9.3 0.2 2.8 2 0 0 2 2 2 2 LYAR-type C2HC zinc finger zf-C2H2_3rep PF18868.1 ADV20631.1 - 0.0067 17.1 2.5 1 10.1 0.2 3.4 3 1 1 4 4 4 1 Zinc finger C2H2-type, 3 repeats ARS2 PF04959.13 ADV20631.1 - 0.011 16.1 0.0 0.19 12.1 0.0 2.4 2 0 0 2 2 2 0 Arsenite-resistance protein 2 FYDLN_acid PF09538.10 ADV20631.1 - 0.015 16.0 18.0 0.19 12.4 10.9 2.8 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) Vps39_2 PF10367.9 ADV20631.1 - 0.046 14.2 0.1 0.11 13.0 0.1 1.6 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 DUF629 PF04780.12 ADV20631.1 - 0.11 11.0 3.1 1.2 7.6 0.6 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF629) zf-C2H2_6 PF13912.6 ADV20631.1 - 0.32 11.0 11.0 0.16 12.0 0.7 3.6 4 0 0 4 4 4 0 C2H2-type zinc finger Ribosomal_60s PF00428.19 ADV20631.1 - 0.43 11.2 6.8 1.4 9.6 6.8 1.8 1 0 0 1 1 1 0 60s Acidic ribosomal protein RNA_pol_3_Rpc31 PF11705.8 ADV20631.1 - 5 7.3 19.1 0.033 14.4 5.8 2.3 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 FAM176 PF14851.6 ADV20631.1 - 5 6.8 10.4 8.5 6.0 3.7 2.7 2 0 0 2 2 2 0 FAM176 family Ribonuc_L-PSP PF01042.21 ADV20632.1 - 9.1e-32 109.6 0.0 1.1e-31 109.4 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP Histone PF00125.24 ADV20633.1 - 2e-17 63.8 0.0 2.6e-17 63.4 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 ADV20633.1 - 3.5e-17 61.8 1.8 7.5e-17 60.8 1.8 1.6 1 0 0 1 1 1 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.23 ADV20633.1 - 8e-07 29.3 0.0 1.4e-06 28.5 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone zinc_ribbon_10 PF10058.9 ADV20635.1 - 2.7e-14 52.6 0.2 4.4e-14 51.9 0.2 1.4 1 0 0 1 1 1 1 Predicted integral membrane zinc-ribbon metal-binding protein SPX PF03105.19 ADV20635.1 - 0.062 13.2 4.0 0.076 12.9 4.0 1.1 1 0 0 1 1 1 0 SPX domain ArsB PF02040.15 ADV20636.1 - 1.9e-12 47.3 16.6 1e-06 28.4 4.3 2.1 2 0 0 2 2 2 2 Arsenical pump membrane protein CitMHS PF03600.16 ADV20636.1 - 0.042 13.0 24.5 0.011 15.0 20.7 1.9 1 1 0 1 1 1 0 Citrate transporter tRNA-synt_2b PF00587.25 ADV20637.1 - 7.6e-38 130.3 0.0 1.8e-37 129.1 0.0 1.6 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 ADV20637.1 - 3.4e-20 72.0 1.2 6.1e-20 71.2 1.2 1.4 1 0 0 1 1 1 1 Anticodon binding domain TGS PF02824.21 ADV20637.1 - 6.6e-14 51.7 0.0 3.4e-13 49.4 0.0 2.1 2 0 0 2 2 2 1 TGS domain tRNA_SAD PF07973.14 ADV20637.1 - 4e-10 39.6 0.0 7.2e-10 38.8 0.0 1.4 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain RRM_1 PF00076.22 ADV20638.1 - 0.00051 19.8 0.0 0.13 12.1 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) LCD1 PF09798.9 ADV20638.1 - 4.9 5.6 9.4 1 7.8 4.7 1.8 2 0 0 2 2 2 0 DNA damage checkpoint protein MFS_1 PF07690.16 ADV20639.1 - 2.4e-12 46.5 51.8 1.6e-08 33.9 34.4 2.6 1 1 2 3 3 3 3 Major Facilitator Superfamily tRNA-synt_2b PF00587.25 ADV20640.1 - 1.3e-24 87.1 0.0 2.2e-24 86.4 0.0 1.4 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 ADV20640.1 - 7.8e-12 45.4 0.6 7.8e-12 45.4 0.6 1.8 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain tRNA-synt_2d PF01409.20 ADV20640.1 - 0.036 13.5 0.0 0.053 13.0 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class II core domain (F) ATP-synt_DE_N PF02823.16 ADV20641.1 - 1.8e-08 34.2 0.1 2.4e-08 33.8 0.1 1.2 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain RL11D PF11088.8 ADV20641.1 - 0.052 13.9 0.0 0.059 13.7 0.0 1.1 1 0 0 1 1 1 0 Glycoprotein encoding membrane proteins RL5A and RL6 Sec23_trunk PF04811.15 ADV20642.1 - 1.8e-70 237.3 0.0 3.1e-70 236.5 0.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 ADV20642.1 - 5.6e-23 80.7 0.2 2.8e-22 78.5 0.0 2.2 2 0 0 2 2 2 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 ADV20642.1 - 3.4e-17 63.0 0.0 1e-16 61.4 0.0 1.9 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 ADV20642.1 - 4.1e-16 58.8 4.6 7.8e-16 57.8 4.6 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger WW PF00397.26 ADV20642.1 - 5.9e-10 39.1 0.9 1.1e-09 38.2 0.9 1.5 1 0 0 1 1 1 1 WW domain Gelsolin PF00626.22 ADV20642.1 - 1.8e-09 37.4 0.0 3.6e-09 36.4 0.0 1.5 1 0 0 1 1 1 1 Gelsolin repeat Vps36-NZF-N PF16988.5 ADV20642.1 - 0.0091 15.4 0.1 0.019 14.3 0.1 1.4 1 0 0 1 1 1 1 Vacuolar protein sorting 36 NZF-N zinc-finger domain DUF1713 PF08213.11 ADV20643.1 - 1.6e-12 47.1 23.3 2.6e-12 46.4 23.3 1.4 1 0 0 1 1 1 1 Mitochondrial domain of unknown function (DUF1713) Med3 PF11593.8 ADV20643.1 - 6.7 5.8 19.7 23 4.0 19.7 2.0 1 1 0 1 1 1 0 Mediator complex subunit 3 fungal LSM PF01423.22 ADV20644.1 - 5.9e-18 64.3 0.0 7.6e-18 64.0 0.0 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 ADV20644.1 - 0.0041 17.2 0.0 0.0062 16.7 0.0 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain Hfq PF17209.3 ADV20644.1 - 0.15 11.8 0.0 0.2 11.3 0.0 1.2 1 0 0 1 1 1 0 Hfq protein FAD_binding_3 PF01494.19 ADV20646.1 - 4.5e-24 85.4 0.0 1.4e-23 83.7 0.0 1.7 1 1 0 1 1 1 1 FAD binding domain SE PF08491.10 ADV20646.1 - 5.9e-05 22.3 0.0 0.00016 20.8 0.0 1.6 1 1 0 1 1 1 1 Squalene epoxidase NAD_binding_8 PF13450.6 ADV20646.1 - 0.0001 22.4 0.2 0.00026 21.2 0.2 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 ADV20646.1 - 0.00036 19.7 0.1 0.016 14.3 0.1 2.5 2 1 0 2 2 2 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 ADV20646.1 - 0.0013 18.0 0.4 0.0053 16.0 0.1 1.8 1 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ADV20646.1 - 0.0071 16.0 0.5 0.035 13.7 0.7 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 ADV20646.1 - 0.023 13.8 0.1 0.031 13.4 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain Trp_halogenase PF04820.14 ADV20646.1 - 0.21 10.4 0.3 11 4.7 0.2 2.7 3 0 0 3 3 3 0 Tryptophan halogenase Peptidase_C14 PF00656.22 ADV20647.1 - 5.4e-33 115.0 0.2 7.1e-33 114.6 0.2 1.1 1 0 0 1 1 1 1 Caspase domain Raptor_N PF14538.6 ADV20647.1 - 0.069 13.1 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 Raptor N-terminal CASPase like domain LRR_6 PF13516.6 ADV20648.1 - 5.5e-11 41.6 16.8 0.14 12.3 0.0 8.5 9 0 0 9 9 9 5 Leucine Rich repeat LRR_4 PF12799.7 ADV20648.1 - 0.022 15.2 10.6 6.8 7.3 2.9 5.8 5 1 1 6 6 6 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ADV20648.1 - 0.14 12.8 7.4 71 4.6 0.0 6.4 7 0 0 7 7 7 0 Leucine Rich Repeat LRR_8 PF13855.6 ADV20648.1 - 3.7 7.4 13.7 28 4.6 2.6 5.2 5 1 2 7 7 7 0 Leucine rich repeat Phage_Gp23 PF10669.9 ADV20649.1 - 0.12 12.7 0.1 0.28 11.5 0.1 1.6 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) DUF2755 PF10954.8 ADV20649.1 - 6.7 6.7 8.4 5.5 7.0 1.0 3.1 2 2 0 2 2 2 0 Protein of unknown function (DUF2755) XPG_I PF00867.18 ADV20650.1 - 4e-22 78.4 0.0 1e-21 77.1 0.0 1.8 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 ADV20650.1 - 2.3e-16 60.1 0.0 4.7e-16 59.1 0.0 1.5 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I_2 PF12813.7 ADV20650.1 - 0.0002 21.0 0.0 0.00036 20.1 0.0 1.3 1 0 0 1 1 1 1 XPG domain containing 5_3_exonuc PF01367.20 ADV20650.1 - 0.00043 20.8 0.0 0.0011 19.5 0.0 1.6 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold HHH_5 PF14520.6 ADV20650.1 - 0.0058 17.2 0.0 0.022 15.4 0.0 1.9 1 0 0 1 1 1 1 Helix-hairpin-helix domain HHH_2 PF12826.7 ADV20650.1 - 0.013 15.6 0.0 0.034 14.2 0.0 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix motif TPR_8 PF13181.6 ADV20650.1 - 0.046 13.9 0.0 0.1 12.9 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_2 PF07719.17 ADV20650.1 - 0.048 13.8 0.0 0.13 12.5 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat S36_mt PF10937.8 ADV20651.1 - 1.3e-17 65.5 0.3 1.5e-17 65.2 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein S36, mitochondrial DUF3446 PF11928.8 ADV20651.1 - 0.0078 16.5 8.5 0.011 16.1 8.5 1.2 1 0 0 1 1 1 1 Early growth response N-terminal domain ORC6 PF05460.13 ADV20651.1 - 0.012 14.9 0.7 0.012 14.9 0.7 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) SR-25 PF10500.9 ADV20651.1 - 0.097 12.3 10.5 0.12 12.0 10.5 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein AF-4 PF05110.13 ADV20651.1 - 0.6 8.1 8.8 0.63 8.1 8.8 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein URO-D PF01208.17 ADV20654.1 - 1.3e-127 425.7 0.0 1.5e-127 425.5 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) DUF1542 PF07564.11 ADV20657.1 - 0.057 13.5 0.0 0.099 12.8 0.0 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1542) Fungal_trans PF04082.18 ADV20658.1 - 3.7e-09 36.0 0.0 5.2e-08 32.2 0.0 2.5 2 1 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ADV20658.1 - 1.6e-08 34.5 7.5 2.7e-08 33.8 7.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain 2H-phosphodiest PF08975.10 ADV20658.1 - 0.13 12.2 0.1 0.59 10.1 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1868) HNH_2 PF13391.6 ADV20659.1 - 1.9e-07 31.1 0.0 3.8e-07 30.1 0.0 1.6 1 0 0 1 1 1 1 HNH endonuclease HNH_2 PF13391.6 ADV20660.1 - 0.0071 16.5 0.0 0.013 15.7 0.0 1.5 1 0 0 1 1 1 1 HNH endonuclease Transketolase_N PF00456.21 ADV20663.1 - 1.1e-18 67.3 0.4 1.2e-17 63.9 0.4 2.0 1 1 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transketolase_C PF02780.20 ADV20663.1 - 1.2e-11 44.5 0.0 8.4e-11 41.8 0.0 2.3 2 0 0 2 2 2 1 Transketolase, C-terminal domain Transket_pyr PF02779.24 ADV20663.1 - 4e-05 23.4 1.2 0.00012 21.8 0.2 2.1 3 0 0 3 3 3 1 Transketolase, pyrimidine binding domain E1_dh PF00676.20 ADV20663.1 - 0.00012 21.2 0.0 0.00019 20.5 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.21 ADV20663.1 - 0.00042 20.1 0.2 0.0018 18.1 0.2 1.9 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain PFOR_II PF17147.4 ADV20663.1 - 0.0036 17.6 0.0 0.014 15.6 0.0 2.0 2 0 0 2 2 2 1 Pyruvate:ferredoxin oxidoreductase core domain II ANAPC4_WD40 PF12894.7 ADV20665.1 - 4e-08 33.4 0.0 1.9 8.8 0.0 5.1 2 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ADV20665.1 - 1.1e-06 29.2 10.1 1.4 9.9 0.1 6.9 6 1 1 7 7 7 2 WD domain, G-beta repeat PD40 PF07676.12 ADV20665.1 - 0.058 13.3 3.1 1.6 8.8 0.0 3.9 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat CD99L2 PF12301.8 ADV20665.1 - 0.083 13.2 5.2 0.18 12.1 5.2 1.6 1 0 0 1 1 1 0 CD99 antigen like protein 2 eIF2A PF08662.11 ADV20665.1 - 0.12 12.2 0.0 3.9 7.3 0.0 2.4 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 ADV20665.1 - 0.21 10.0 0.9 0.76 8.2 0.6 1.8 1 1 1 2 2 2 0 Cytochrome D1 heme domain PWI PF01480.17 ADV20666.1 - 8.7e-26 90.0 0.0 1.3e-25 89.4 0.0 1.2 1 0 0 1 1 1 1 PWI domain GPI-anchored PF10342.9 ADV20667.1 - 1.5e-11 44.9 1.1 1.5e-11 44.9 1.1 2.8 2 1 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family SAPS PF04499.15 ADV20667.1 - 0.14 10.9 0.7 0.15 10.9 0.7 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Presenilin PF01080.17 ADV20667.1 - 0.58 8.9 6.8 0.75 8.5 6.8 1.1 1 0 0 1 1 1 0 Presenilin Macoilin PF09726.9 ADV20667.1 - 7.3 5.0 22.4 11 4.4 22.4 1.2 1 0 0 1 1 1 0 Macoilin family UPF0220 PF05255.11 ADV20668.1 - 4.9e-48 162.8 0.0 5.7e-48 162.6 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) PASTA PF03793.19 ADV20668.1 - 0.1 12.5 0.0 0.15 12.0 0.0 1.2 1 0 0 1 1 1 0 PASTA domain Phage_T7_Capsid PF05396.11 ADV20669.1 - 0.0047 17.3 0.0 0.0094 16.3 0.0 1.4 1 1 0 1 1 1 1 Phage T7 capsid assembly protein GRIN_C PF15235.6 ADV20669.1 - 0.028 14.6 1.0 0.037 14.3 1.0 1.2 1 0 0 1 1 1 0 G protein-regulated inducer of neurite outgrowth C-terminus HSF_DNA-bind PF00447.17 ADV20670.1 - 2.3e-31 108.3 0.2 3.7e-31 107.6 0.2 1.3 1 0 0 1 1 1 1 HSF-type DNA-binding Mannosyl_trans3 PF11051.8 ADV20672.1 - 1.4e-29 103.3 0.0 1.1e-23 84.0 0.0 2.2 2 0 0 2 2 2 2 Mannosyltransferase putative WD40 PF00400.32 ADV20673.1 - 1.5e-20 73.1 10.7 1.7e-07 31.8 0.0 6.4 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV20673.1 - 1.5e-06 28.4 0.0 0.091 13.1 0.0 4.3 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ADV20673.1 - 0.00063 18.8 0.0 0.0046 16.0 0.0 2.2 3 0 0 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ADV20673.1 - 0.023 13.4 0.0 0.39 9.3 0.0 2.4 3 0 0 3 3 3 0 Nucleoporin Nup120/160 PQQ PF01011.21 ADV20673.1 - 0.047 13.6 0.8 8.6 6.5 0.0 3.5 3 0 0 3 3 3 0 PQQ enzyme repeat Methyltransf_4 PF02390.17 ADV20674.1 - 3.4e-55 186.1 0.0 4.2e-55 185.9 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_25 PF13649.6 ADV20674.1 - 0.0004 21.0 0.0 0.0036 18.0 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ADV20674.1 - 0.0012 18.4 0.0 0.98 8.9 0.0 2.3 1 1 1 2 2 2 2 Methyltransferase small domain Methyltransf_12 PF08242.12 ADV20674.1 - 0.0055 17.4 0.0 0.027 15.2 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 ADV20674.1 - 0.014 16.0 0.0 0.25 12.0 0.0 2.3 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 ADV20674.1 - 0.19 11.5 0.0 0.79 9.5 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase domain Vault PF01505.18 ADV20674.1 - 0.33 11.2 1.2 0.51 10.5 0.2 1.8 2 0 0 2 2 2 0 Major Vault Protein repeat domain WD40 PF00400.32 ADV20676.1 - 1.2e-15 57.6 10.7 0.0013 19.5 0.2 6.2 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV20676.1 - 7e-07 29.5 0.0 0.58 10.5 0.0 3.5 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain F-box-like PF12937.7 ADV20677.1 - 0.00018 21.4 0.3 0.00018 21.4 0.3 2.7 4 0 0 4 4 4 1 F-box-like F-box PF00646.33 ADV20677.1 - 0.082 12.8 0.3 0.68 9.9 0.0 2.3 2 0 0 2 2 2 0 F-box domain F_bP_aldolase PF01116.20 ADV20678.1 - 1.4e-93 313.4 0.0 1.6e-93 313.2 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II Torsin PF06309.11 ADV20678.1 - 0.028 14.5 0.0 0.056 13.5 0.0 1.4 1 0 0 1 1 1 0 Torsin DNApol_Exo PF18136.1 ADV20679.1 - 2.4e-101 338.6 0.0 4.2e-101 337.8 0.0 1.4 1 0 0 1 1 1 1 DNA mitochondrial polymerase exonuclease domain DNA_pol_A PF00476.20 ADV20679.1 - 8.1e-50 169.9 0.0 1.4e-49 169.2 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family A Phage_ASH PF10554.9 ADV20679.1 - 0.028 14.8 0.3 0.067 13.5 0.3 1.6 1 0 0 1 1 1 0 Ash protein family Utp14 PF04615.13 ADV20680.1 - 2e-161 539.3 74.6 2e-161 539.3 74.6 2.6 1 1 1 2 2 2 1 Utp14 protein MPP6 PF10175.9 ADV20680.1 - 0.0071 16.8 5.9 0.0071 16.8 5.9 8.1 4 4 2 6 6 6 1 M-phase phosphoprotein 6 LisH PF08513.11 ADV20681.1 - 3.7e-05 23.5 0.0 6.6e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 LisH MCU PF04678.13 ADV20682.1 - 0.25 11.4 8.5 0.71 9.9 8.5 1.8 1 0 0 1 1 1 0 Mitochondrial calcium uniporter adh_short_C2 PF13561.6 ADV20683.1 - 1.1e-66 224.8 0.1 1.3e-66 224.6 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ADV20683.1 - 3.9e-47 160.3 0.2 4.8e-47 159.9 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ADV20683.1 - 1.2e-07 31.8 1.0 1.5e-07 31.5 0.1 1.5 2 0 0 2 2 2 1 KR domain GATA PF00320.27 ADV20684.1 - 1.1e-08 34.5 0.9 2.2e-08 33.5 0.9 1.5 1 0 0 1 1 1 1 GATA zinc finger Zn-ribbon_8 PF09723.10 ADV20684.1 - 0.2 11.8 0.1 0.41 10.8 0.1 1.5 1 0 0 1 1 1 0 Zinc ribbon domain ADH_zinc_N PF00107.26 ADV20686.1 - 6.8e-14 52.0 0.0 2.1e-13 50.4 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ADV20686.1 - 1.7e-05 24.6 0.2 5e-05 23.1 0.2 1.8 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 ADV20686.1 - 0.0009 20.3 0.0 0.0018 19.3 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase MFS_1 PF07690.16 ADV20687.1 - 9e-33 113.6 46.1 1.2e-32 113.2 42.8 2.5 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 ADV20687.1 - 2.1e-08 33.1 8.4 2.1e-08 33.1 8.4 2.0 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 ADV20687.1 - 4.4e-06 25.8 8.3 4.4e-06 25.8 8.3 3.4 1 1 2 3 3 3 1 Sugar (and other) transporter Phage_holin_7_1 PF16081.5 ADV20687.1 - 1.4 9.0 5.9 0.37 11.0 0.9 2.6 3 0 0 3 3 3 0 Mycobacterial 2 TMS Phage Holin (M2 Hol) Family TPR_2 PF07719.17 ADV20688.1 - 1.7e-22 77.6 30.4 0.0022 18.0 0.3 14.6 16 1 0 16 16 15 5 Tetratricopeptide repeat TPR_1 PF00515.28 ADV20688.1 - 1.1e-18 66.2 25.8 0.016 15.0 0.0 11.3 12 1 0 12 12 12 5 Tetratricopeptide repeat TPR_6 PF13174.6 ADV20688.1 - 1.3e-14 53.8 19.1 0.0042 17.6 0.0 10.6 10 0 0 10 10 10 3 Tetratricopeptide repeat TPR_12 PF13424.6 ADV20688.1 - 2.2e-12 47.1 49.4 2.3e-07 31.0 4.9 12.1 7 4 7 15 15 15 4 Tetratricopeptide repeat TPR_19 PF14559.6 ADV20688.1 - 5.5e-12 46.0 35.8 0.0045 17.5 0.0 11.3 8 4 6 14 14 14 4 Tetratricopeptide repeat TPR_8 PF13181.6 ADV20688.1 - 8e-12 44.4 13.8 0.094 13.0 0.0 10.7 11 0 0 11 11 11 3 Tetratricopeptide repeat TPR_14 PF13428.6 ADV20688.1 - 1e-09 38.4 63.1 0.00016 22.2 0.6 14.2 12 3 4 16 16 12 4 Tetratricopeptide repeat TPR_16 PF13432.6 ADV20688.1 - 3.6e-08 33.9 62.1 0.00058 20.5 1.0 11.3 11 2 1 12 12 11 4 Tetratricopeptide repeat TPR_7 PF13176.6 ADV20688.1 - 5.5e-08 32.3 22.0 0.01 15.8 0.1 9.9 10 1 0 10 10 10 2 Tetratricopeptide repeat TPR_11 PF13414.6 ADV20688.1 - 7.7e-08 31.9 10.3 5.8 6.7 0.0 8.5 8 1 1 9 9 9 1 TPR repeat TPR_17 PF13431.6 ADV20688.1 - 5.4e-05 23.3 13.3 72 4.1 0.0 10.7 13 0 0 13 13 11 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ADV20688.1 - 0.00023 21.3 7.6 0.28 11.4 0.5 6.2 5 2 1 6 6 6 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 ADV20688.1 - 0.0027 17.5 37.6 0.3 11.0 0.5 10.1 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_9 PF13371.6 ADV20688.1 - 0.0093 16.1 14.6 0.029 14.5 0.6 5.8 5 1 0 5 5 5 1 Tetratricopeptide repeat MIF4G_like PF09088.11 ADV20689.1 - 6.6e-83 277.2 0.2 1.8e-82 275.8 0.0 1.8 2 0 0 2 2 2 1 MIF4G like MIF4G_like_2 PF09090.11 ADV20689.1 - 6.7e-61 206.1 0.0 9.5e-61 205.6 0.0 1.2 1 0 0 1 1 1 1 MIF4G like HLH PF00010.26 ADV20690.1 - 1.1e-09 38.1 0.4 4.1e-09 36.2 0.0 2.2 2 1 0 2 2 2 1 Helix-loop-helix DNA-binding domain ADIP PF11559.8 ADV20690.1 - 0.55 10.3 4.1 0.61 10.2 1.4 2.1 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding ZapB PF06005.12 ADV20690.1 - 7 7.2 8.7 5.5 7.5 0.5 2.5 2 0 0 2 2 2 0 Cell division protein ZapB BING4CT PF08149.11 ADV20692.1 - 1.4e-33 114.6 0.0 1.7e-31 107.9 0.0 3.1 3 0 0 3 3 3 1 BING4CT (NUC141) domain WD40 PF00400.32 ADV20692.1 - 2e-06 28.4 0.3 0.00035 21.3 0.0 4.3 6 0 0 6 6 6 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV20692.1 - 0.0019 18.5 0.1 0.36 11.1 0.0 3.7 4 1 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 ADV20692.1 - 0.0044 16.6 0.0 0.0098 15.5 0.0 1.6 1 0 0 1 1 1 1 PQQ-like domain Coatomer_WDAD PF04053.14 ADV20692.1 - 0.031 13.3 0.1 0.048 12.7 0.1 1.2 1 0 0 1 1 1 0 Coatomer WD associated region Histone PF00125.24 ADV20693.1 - 7.2e-21 74.9 2.2 8.5e-21 74.7 2.2 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 ADV20693.1 - 1e-05 25.7 0.0 2.7e-05 24.3 0.0 1.7 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 ADV20693.1 - 0.0031 18.0 0.0 0.0053 17.2 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A Bt_P21 PF05560.11 ADV20693.1 - 0.075 12.6 0.1 0.096 12.3 0.1 1.2 1 0 0 1 1 1 0 Bacillus thuringiensis P21 molecular chaperone protein Histone PF00125.24 ADV20694.1 - 1.2e-50 171.3 4.7 1.3e-50 171.1 4.7 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 ADV20694.1 - 4.5e-05 23.5 1.1 4.8e-05 23.4 0.1 1.6 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 ADV20694.1 - 5.7e-05 23.4 0.0 9.3e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 CENP-S protein PAF PF15715.5 ADV20694.1 - 0.00024 21.7 1.4 0.0003 21.4 1.4 1.2 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CBFD_NFYB_HMF PF00808.23 ADV20694.1 - 0.0022 18.3 0.1 0.0044 17.3 0.1 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 ADV20694.1 - 0.084 13.0 0.3 0.14 12.3 0.1 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit DEAD PF00270.29 ADV20696.1 - 4.1e-42 143.9 0.0 6.5e-40 136.7 0.0 2.6 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ADV20696.1 - 5.5e-25 87.9 0.0 2.1e-24 86.0 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DBP10CT PF08147.12 ADV20696.1 - 4.2e-18 65.4 2.2 4.2e-18 65.4 2.2 2.6 2 0 0 2 2 2 1 DBP10CT (NUC160) domain ResIII PF04851.15 ADV20696.1 - 1.6e-05 24.9 0.0 3.4e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 ADV20696.1 - 0.011 14.9 0.0 0.02 14.1 0.0 1.3 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase Ndc1_Nup PF09531.10 ADV20696.1 - 1.2 7.7 3.4 2.2 6.9 3.4 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Vps16_C PF04840.12 ADV20697.1 - 3.4e-87 292.5 0.0 4.8e-87 292.0 0.0 1.1 1 0 0 1 1 1 1 Vps16, C-terminal region Vps16_N PF04841.13 ADV20697.1 - 2.2e-78 263.8 0.0 2.9e-78 263.5 0.0 1.1 1 0 0 1 1 1 1 Vps16, N-terminal region ATG_C PF09333.11 ADV20698.1 - 2.8e-38 130.2 0.2 1.3e-37 128.1 0.1 2.2 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain Chorein_N PF12624.7 ADV20698.1 - 6.1e-12 45.7 0.0 1.4e-11 44.5 0.0 1.6 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 ATG2_CAD PF13329.6 ADV20698.1 - 2.1e-06 27.5 0.0 8e-06 25.6 0.0 2.0 1 1 0 1 1 1 1 Autophagy-related protein 2 CAD motif VPS13_C PF16909.5 ADV20698.1 - 4.4e-06 26.6 0.2 4.4e-05 23.3 0.1 2.6 2 1 0 2 2 2 1 Vacuolar-sorting-associated 13 protein C-terminal SR-25 PF10500.9 ADV20699.1 - 0.017 14.7 16.1 0.032 13.9 16.1 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Pkinase PF00069.25 ADV20700.1 - 1.6e-60 204.7 0.0 2e-60 204.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV20700.1 - 4.7e-24 85.1 0.0 6.8e-24 84.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ADV20700.1 - 0.00023 20.6 0.0 0.00044 19.7 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 ADV20700.1 - 0.015 15.3 0.0 0.031 14.2 0.0 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family Choline_kinase PF01633.20 ADV20700.1 - 0.018 14.6 0.0 0.026 14.1 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kdo PF06293.14 ADV20700.1 - 0.1 11.9 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family MUG113 PF13455.6 ADV20700.1 - 0.16 12.7 0.1 0.55 11.0 0.0 2.0 2 0 0 2 2 2 0 Meiotically up-regulated gene 113 CS PF04969.16 ADV20701.1 - 4.3e-08 34.1 0.2 1.2e-07 32.6 0.2 1.8 1 0 0 1 1 1 1 CS domain Band_7 PF01145.25 ADV20702.1 - 2.4e-25 89.6 0.4 1.6e-24 86.9 0.6 1.9 1 1 1 2 2 2 1 SPFH domain / Band 7 family YdfA_immunity PF12127.8 ADV20702.1 - 0.00027 20.1 1.6 0.00036 19.7 1.6 1.1 1 0 0 1 1 1 1 SigmaW regulon antibacterial ODAM PF15424.6 ADV20702.1 - 0.1 12.1 0.0 0.2 11.2 0.0 1.4 1 0 0 1 1 1 0 Odontogenic ameloblast-associated family ECR1_N PF14382.6 ADV20703.1 - 2.1e-17 62.6 0.4 4e-17 61.7 0.4 1.5 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region KH_6 PF15985.5 ADV20703.1 - 1.6e-13 50.8 0.0 3e-13 49.9 0.0 1.5 1 0 0 1 1 1 1 KH domain Kinesin PF00225.23 ADV20704.1 - 4.6e-98 328.2 0.0 8.3e-98 327.4 0.0 1.4 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ADV20704.1 - 3e-25 88.9 0.0 6.4e-25 87.8 0.0 1.5 1 0 0 1 1 1 1 Microtubule binding DUF4694 PF15765.5 ADV20704.1 - 0.14 12.2 9.3 0.81 9.7 1.1 4.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4694) Noelin-1 PF12308.8 ADV20704.1 - 0.19 11.8 3.0 0.13 12.2 0.4 2.1 2 0 0 2 2 2 0 Neurogenesis glycoprotein ADH_zinc_N PF00107.26 ADV20706.1 - 0.00015 21.8 0.1 0.00025 21.0 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ADV20706.1 - 0.0035 18.4 0.0 0.0068 17.4 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase EAV_GP5 PF15981.5 ADV20707.1 - 0.073 13.5 0.0 0.11 12.9 0.0 1.2 1 0 0 1 1 1 0 Envelope glycoprotein GP 5 of equine arteritis virus RRM_1 PF00076.22 ADV20708.1 - 1.4e-16 60.1 0.0 2e-16 59.6 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ADV20708.1 - 1.7e-05 24.4 0.0 2.7e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ADV20708.1 - 0.015 15.1 0.0 0.028 14.3 0.0 1.4 1 1 0 1 1 1 0 Occluded RNA-recognition motif WBS_methylT PF12589.8 ADV20709.1 - 3.3e-21 75.8 13.7 5.7e-21 75.1 13.7 1.4 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_25 PF13649.6 ADV20709.1 - 2.8e-09 37.5 0.0 7.2e-09 36.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ADV20709.1 - 3e-09 37.4 0.0 7.2e-09 36.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ADV20709.1 - 3.2e-06 27.1 0.0 5.7e-06 26.3 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ADV20709.1 - 4.5e-05 24.1 0.6 0.00017 22.3 0.0 2.3 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 ADV20709.1 - 0.0001 22.1 0.0 0.00016 21.5 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 ADV20709.1 - 0.00063 19.8 0.0 0.0033 17.4 0.0 2.1 2 1 0 2 2 2 1 Methyltransferase domain AdoMet_MTase PF07757.13 ADV20709.1 - 0.014 15.7 0.0 0.032 14.6 0.0 1.6 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase PCMT PF01135.19 ADV20709.1 - 0.016 15.0 0.0 0.027 14.2 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) N6_N4_Mtase PF01555.18 ADV20709.1 - 0.025 14.3 0.2 0.78 9.4 0.0 2.1 2 0 0 2 2 2 0 DNA methylase DUF3578 PF12102.8 ADV20709.1 - 0.079 12.5 0.1 0.14 11.8 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3578) MTS PF05175.14 ADV20709.1 - 0.12 11.9 0.1 0.31 10.6 0.1 1.7 1 1 1 2 2 2 0 Methyltransferase small domain PrmA PF06325.13 ADV20709.1 - 0.19 11.1 0.3 0.39 10.1 0.0 1.6 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) HATPase_c PF02518.26 ADV20710.1 - 5.5e-18 65.5 1.0 1.2e-17 64.4 0.1 2.1 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ADV20710.1 - 1.1e-17 64.3 0.0 2.9e-12 46.7 0.0 3.3 3 0 0 3 3 3 2 Response regulator receiver domain HisKA PF00512.25 ADV20710.1 - 7.2e-13 48.4 0.1 1.6e-12 47.3 0.1 1.6 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain GAF PF01590.26 ADV20710.1 - 1.3e-06 29.1 0.0 0.03 14.9 0.0 2.7 2 0 0 2 2 2 2 GAF domain GAF_3 PF13492.6 ADV20710.1 - 0.11 12.9 0.2 1.6 9.1 0.0 3.0 4 0 0 4 4 4 0 GAF domain XRN1_DBM PF18245.1 ADV20711.1 - 6.4 6.9 14.8 0.11 12.5 5.6 3.0 3 0 0 3 3 3 0 5-3 exonuclease XRN1 DCP1-binding motif Ribonuc_2-5A PF06479.12 ADV20713.1 - 1.2e-44 151.5 0.0 1.9e-44 150.9 0.0 1.3 1 0 0 1 1 1 1 Ribonuclease 2-5A Pkinase PF00069.25 ADV20713.1 - 3e-39 135.0 0.0 1.1e-37 129.8 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV20713.1 - 2.3e-22 79.5 0.0 2.8e-21 76.0 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ADV20713.1 - 0.00026 19.9 0.0 0.00083 18.2 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase PQQ PF01011.21 ADV20713.1 - 0.00075 19.3 0.0 0.028 14.3 0.0 2.8 2 0 0 2 2 2 1 PQQ enzyme repeat Kdo PF06293.14 ADV20713.1 - 0.0026 17.2 0.1 0.0045 16.4 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ADV20713.1 - 0.027 14.4 0.0 0.056 13.4 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family VirB8 PF04335.13 ADV20713.1 - 0.14 12.0 0.0 0.22 11.3 0.0 1.2 1 0 0 1 1 1 0 VirB8 protein DUF3185 PF11381.8 ADV20713.1 - 0.18 11.8 0.3 0.59 10.2 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3185) Pox_Ag35 PF03286.14 ADV20713.1 - 2.4 7.9 6.8 3.9 7.2 6.8 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein SWIRM-assoc_2 PF16496.5 ADV20713.1 - 2.5 6.9 10.3 3.7 6.3 10.3 1.2 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal PBP1_TM PF14812.6 ADV20713.1 - 5.7 7.4 6.2 24 5.4 3.5 2.5 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Fungal_trans PF04082.18 ADV20714.1 - 2.6e-10 39.8 0.0 4.6e-10 39.0 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Sel1 PF08238.12 ADV20715.1 - 2.9e-11 43.7 16.5 6.3e-07 29.9 0.4 5.9 6 0 0 6 6 6 3 Sel1 repeat TPR_2 PF07719.17 ADV20715.1 - 0.12 12.5 5.7 2.3 8.5 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Kinesin PF00225.23 ADV20716.1 - 1e-114 383.0 0.4 1e-114 383.0 0.4 2.1 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 ADV20716.1 - 3e-26 92.1 1.8 6.4e-26 91.1 0.1 2.5 2 0 0 2 2 2 1 Microtubule binding Sec2p PF06428.11 ADV20716.1 - 0.014 15.4 2.4 0.014 15.4 2.4 7.6 3 2 1 6 6 6 0 GDP/GTP exchange factor Sec2p Cnn_1N PF07989.11 ADV20716.1 - 0.017 15.3 5.6 0.017 15.3 5.6 7.3 5 2 1 6 6 6 0 Centrosomin N-terminal motif 1 PKcGMP_CC PF16808.5 ADV20716.1 - 0.32 10.9 23.7 0.034 14.0 1.5 6.1 5 0 0 5 5 5 0 Coiled-coil N-terminus of cGMP-dependent protein kinase AAA_22 PF13401.6 ADV20716.1 - 4.2 7.6 6.1 4 7.7 0.3 3.2 2 1 0 2 2 2 0 AAA domain Bacillus_HBL PF05791.11 ADV20716.1 - 4.7 7.0 27.6 1.7 8.4 4.5 4.9 2 2 3 5 5 5 0 Bacillus haemolytic enterotoxin (HBL) EamA PF00892.20 ADV20717.1 - 4.2e-07 30.2 31.5 1.7e-05 25.0 5.3 3.7 3 1 0 3 3 3 2 EamA-like transporter family SLC35F PF06027.12 ADV20717.1 - 1.3e-05 24.8 8.1 1.3e-05 24.8 8.1 1.6 2 0 0 2 2 2 1 Solute carrier family 35 DUF1011 PF06237.12 ADV20717.1 - 2.9 8.3 10.7 1.8 8.9 0.7 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1011) CDP-OH_P_transf PF01066.21 ADV20718.1 - 2.2e-10 41.2 0.7 2.2e-10 41.2 0.7 1.8 2 0 0 2 2 2 1 CDP-alcohol phosphatidyltransferase HA PF03457.14 ADV20718.1 - 0.17 12.3 0.1 0.37 11.2 0.1 1.5 1 0 0 1 1 1 0 Helicase associated domain RCC1 PF00415.18 ADV20720.1 - 4.8e-15 55.9 11.7 0.00011 22.8 0.0 6.7 6 1 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ADV20720.1 - 3.6e-07 29.8 16.5 0.011 15.5 0.0 6.3 7 0 0 7 7 7 3 Regulator of chromosome condensation (RCC1) repeat FMO-like PF00743.19 ADV20722.1 - 4.3e-36 124.4 0.1 3.2e-24 85.2 0.0 3.1 3 0 0 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 ADV20722.1 - 1.7e-08 34.1 0.0 6.6e-05 22.3 0.0 3.0 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 ADV20722.1 - 9.9e-05 21.6 0.1 0.053 12.6 0.0 3.0 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 ADV20722.1 - 0.00013 22.1 0.0 0.00033 20.8 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 ADV20722.1 - 0.0002 21.4 0.0 0.00091 19.2 0.0 2.1 2 0 0 2 2 2 1 FAD-NAD(P)-binding DAO PF01266.24 ADV20722.1 - 0.014 15.0 0.0 0.73 9.3 0.1 2.3 2 0 0 2 2 2 0 FAD dependent oxidoreductase DUF3760 PF12586.8 ADV20723.1 - 1e-14 54.4 1.3 1.7e-14 53.7 1.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3760) Mito_carr PF00153.27 ADV20724.1 - 6.5e-62 205.5 0.4 9.8e-22 76.7 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_6 PF13405.6 ADV20724.1 - 5.8e-06 25.8 0.1 8.2e-05 22.2 0.0 2.5 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 ADV20724.1 - 6.6e-05 22.2 0.2 0.00054 19.3 0.0 2.5 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.6 ADV20724.1 - 0.00084 18.7 0.1 0.002 17.6 0.1 1.6 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 ADV20724.1 - 0.005 17.3 0.1 0.016 15.7 0.1 1.8 1 1 0 1 1 1 1 EF-hand domain pair Ribosomal_L15e PF00827.17 ADV20725.1 - 7.1e-88 293.3 10.9 8.1e-88 293.1 10.9 1.0 1 0 0 1 1 1 1 Ribosomal L15 NAD_binding_2 PF03446.15 ADV20727.1 - 1.8e-19 70.4 0.0 2.7e-19 69.9 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 ADV20727.1 - 4.3e-10 39.9 0.0 9.4e-10 38.8 0.0 1.5 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Shikimate_DH PF01488.20 ADV20727.1 - 3.8e-05 23.8 0.0 7.4e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 ADV20727.1 - 0.0044 17.6 0.0 0.0088 16.6 0.0 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent DAGK_cat PF00781.24 ADV20727.1 - 0.081 12.6 0.0 0.34 10.5 0.0 2.1 2 0 0 2 2 2 0 Diacylglycerol kinase catalytic domain Archease PF01951.16 ADV20727.1 - 0.094 13.0 0.1 0.27 11.5 0.0 1.7 2 0 0 2 2 2 0 Archease protein family (MTH1598/TM1083) UDPG_MGDP_dh PF00984.19 ADV20727.1 - 0.14 12.4 0.0 0.36 11.1 0.0 1.7 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, central domain GFO_IDH_MocA PF01408.22 ADV20731.1 - 2.7e-20 73.4 0.0 1.1e-19 71.4 0.0 1.9 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ADV20731.1 - 3.6e-08 33.4 0.0 9.1e-08 32.1 0.0 1.7 1 1 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain Metallophos PF00149.28 ADV20732.1 - 1.3e-26 94.3 0.0 2.4e-26 93.5 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PPP5 PF08321.12 ADV20732.1 - 3.3e-23 81.8 0.0 7.4e-23 80.7 0.0 1.6 1 0 0 1 1 1 1 PPP5 TPR repeat region TPR_1 PF00515.28 ADV20732.1 - 4e-17 61.2 0.0 0.00032 20.4 0.0 3.8 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 ADV20732.1 - 1e-13 50.2 0.1 0.003 17.5 0.1 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 ADV20732.1 - 3.2e-08 33.1 0.7 0.053 13.2 0.0 4.0 4 0 0 4 4 4 2 TPR repeat TPR_17 PF13431.6 ADV20732.1 - 6.2e-06 26.2 0.0 0.099 13.1 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ADV20732.1 - 6.5e-06 26.0 0.2 0.61 10.4 0.0 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 ADV20732.1 - 0.0015 19.2 0.0 0.34 11.6 0.0 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 ADV20732.1 - 0.011 16.5 0.0 2.2 9.3 0.0 3.0 1 1 2 3 3 3 0 Tetratricopeptide repeat TPR_15 PF13429.6 ADV20732.1 - 0.017 14.4 0.0 2.1 7.5 0.0 2.1 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 ADV20732.1 - 0.043 14.1 0.0 0.96 9.8 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_9 PF13371.6 ADV20732.1 - 0.053 13.7 0.0 1.1 9.4 0.0 2.2 1 1 1 2 2 2 0 Tetratricopeptide repeat Sulfatase PF00884.23 ADV20733.1 - 3.8e-55 187.5 0.1 4.9e-55 187.1 0.1 1.1 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 ADV20733.1 - 0.044 13.4 0.0 0.63 9.6 0.0 2.2 2 1 0 2 2 2 0 Type I phosphodiesterase / nucleotide pyrophosphatase DUF4976 PF16347.5 ADV20733.1 - 0.077 13.3 0.0 0.17 12.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4976) CxC1 PF18802.1 ADV20734.1 - 7.1e-18 64.7 0.1 1.8e-17 63.4 0.1 1.6 1 0 0 1 1 1 1 CxC1 like cysteine cluster associated with KDZ transposases CxC2 PF18803.1 ADV20734.1 - 4.4e-07 30.0 0.0 9.1e-07 29.0 0.0 1.5 1 0 0 1 1 1 1 CxC2 like cysteine cluster associated with KDZ transposases TauD PF02668.16 ADV20735.1 - 3.3e-51 174.7 0.1 4.3e-51 174.3 0.1 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Lung_7-TM_R PF06814.13 ADV20736.1 - 3.2e-61 207.2 15.2 3.9e-61 206.9 15.2 1.1 1 0 0 1 1 1 1 Lung seven transmembrane receptor MARVEL PF01284.23 ADV20736.1 - 0.39 10.7 16.0 4.4 7.3 10.6 3.0 1 1 1 2 2 2 0 Membrane-associating domain Vps51 PF08700.11 ADV20738.1 - 2.4e-14 53.2 0.3 6.8e-14 51.7 0.3 1.8 1 0 0 1 1 1 1 Vps51/Vps67 Dor1 PF04124.12 ADV20738.1 - 0.02 13.6 1.6 0.029 13.1 0.9 1.6 2 0 0 2 2 2 0 Dor1-like family Fes1 PF08609.10 ADV20738.1 - 0.1 13.5 0.1 0.1 13.5 0.1 3.7 4 0 0 4 4 4 0 Nucleotide exchange factor Fes1 DUF913 PF06025.12 ADV20738.1 - 0.92 8.4 7.2 0.1 11.5 2.2 2.0 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) DUF4246 PF14033.6 ADV20738.1 - 3.1 6.8 8.1 0.55 9.3 3.9 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4246) AnfO_nitrog PF09582.10 ADV20738.1 - 4.8 6.5 8.7 2.7 7.3 5.1 2.4 2 0 0 2 2 2 0 Iron only nitrogenase protein AnfO (AnfO_nitrog) FlgM PF04316.13 ADV20739.1 - 0.032 14.6 0.1 0.032 14.6 0.1 2.1 2 0 0 2 2 2 0 Anti-sigma-28 factor, FlgM DUF2828 PF11443.8 ADV20739.1 - 1.2 7.1 9.1 1.4 6.9 9.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) RR_TM4-6 PF06459.12 ADV20739.1 - 2.5 7.9 9.2 2.6 7.8 9.2 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SYS1 PF09801.9 ADV20740.1 - 6.3e-20 71.8 1.7 8.4e-20 71.4 1.7 1.1 1 0 0 1 1 1 1 Integral membrane protein S linking to the trans Golgi network COesterase PF00135.28 ADV20742.1 - 1.2e-61 209.2 0.0 1.6e-61 208.7 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 ADV20742.1 - 0.00011 22.1 0.5 0.00076 19.4 0.5 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold DUF563 PF04577.14 ADV20743.1 - 2e-19 70.6 0.0 1.1e-18 68.1 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF563) Peptidase_M48 PF01435.18 ADV20744.1 - 3.4e-33 115.1 0.0 1.1e-32 113.4 0.0 1.7 1 1 0 1 1 1 1 Peptidase family M48 His_Phos_1 PF00300.22 ADV20745.1 - 1.2e-13 51.2 0.1 1.7e-13 50.7 0.1 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) PrmA PF06325.13 ADV20746.1 - 6e-07 29.2 0.2 9.1e-07 28.5 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 ADV20746.1 - 1.7e-05 25.4 0.1 0.00026 21.7 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 ADV20746.1 - 8.6e-05 22.4 0.0 0.00015 21.7 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ADV20746.1 - 0.00042 19.9 0.1 0.00087 18.9 0.1 1.5 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_11 PF08241.12 ADV20746.1 - 0.023 15.3 0.1 0.14 12.8 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain Cons_hypoth95 PF03602.15 ADV20746.1 - 0.066 12.8 0.1 0.11 12.2 0.1 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 tRNA-synt_2d PF01409.20 ADV20747.1 - 2.7e-45 154.8 0.0 4.1e-26 91.9 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) FDX-ACB PF03147.14 ADV20747.1 - 2.2e-21 76.1 0.0 4.9e-21 75.0 0.0 1.6 1 0 0 1 1 1 1 Ferredoxin-fold anticodon binding domain DUF1180 PF06679.12 ADV20748.1 - 0.01 16.3 0.6 0.1 13.0 0.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) Tad PF13400.6 ADV20748.1 - 0.018 15.3 0.8 0.039 14.3 0.8 1.5 1 0 0 1 1 1 0 Putative Flp pilus-assembly TadE/G-like SelK_SelG PF10961.8 ADV20748.1 - 0.91 10.2 0.1 0.91 10.2 0.1 2.6 3 0 0 3 3 3 0 Selenoprotein SelK_SelG SR-25 PF10500.9 ADV20748.1 - 2.8 7.5 8.3 4.7 6.7 8.3 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Ank_5 PF13857.6 ADV20749.1 - 5.6e-09 36.1 0.7 1.3e-06 28.6 0.2 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) TIG PF01833.24 ADV20749.1 - 2.1e-07 30.9 0.6 9.5e-07 28.8 0.1 2.4 2 0 0 2 2 2 1 IPT/TIG domain Ank_2 PF12796.7 ADV20749.1 - 3e-07 30.9 0.0 7.1e-07 29.7 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ADV20749.1 - 1.7e-06 28.5 0.3 0.025 15.2 0.0 2.9 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ADV20749.1 - 5e-05 23.4 0.0 0.16 12.6 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank PF00023.30 ADV20749.1 - 0.009 16.4 0.0 10 6.8 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat UvrD-helicase PF00580.21 ADV20750.1 - 1e-67 228.9 0.8 3.2e-67 227.3 0.1 2.1 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain UvrD_C PF13361.6 ADV20750.1 - 2.6e-55 188.2 0.0 1.3e-54 185.9 0.0 2.1 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 ADV20750.1 - 1.1e-33 116.6 0.0 2.6e-33 115.4 0.0 1.7 1 1 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 ADV20750.1 - 1.6e-12 47.1 0.1 4e-12 45.8 0.1 1.7 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_30 PF13604.6 ADV20750.1 - 2.3e-07 30.7 0.0 0.01 15.5 0.0 2.4 1 1 0 2 2 2 2 AAA domain AAA_12 PF13087.6 ADV20750.1 - 2.4e-05 24.0 0.0 0.00013 21.6 0.0 2.2 2 0 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.18 ADV20750.1 - 9.6e-05 22.2 0.1 0.066 12.9 0.0 3.3 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.6 ADV20750.1 - 0.00017 21.9 0.4 0.26 11.6 0.1 2.8 2 1 0 3 3 3 2 AAA domain AAA_11 PF13086.6 ADV20750.1 - 0.0083 15.9 2.4 0.012 15.4 0.1 2.3 2 0 0 2 2 2 1 AAA domain Mito_carr PF00153.27 ADV20751.1 - 1.1e-67 224.0 2.6 2.4e-21 75.4 0.2 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 ADV20751.1 - 0.026 13.7 5.3 3.3 6.8 0.0 3.8 3 2 2 5 5 5 0 Gammaproteobacterial serine protease FSH1 PF03959.13 ADV20752.1 - 1.9e-58 197.6 0.0 2.3e-58 197.4 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_1 PF00561.20 ADV20752.1 - 0.11 12.1 0.0 8.9 5.9 0.0 2.2 2 0 0 2 2 2 0 alpha/beta hydrolase fold zf-CCCH_4 PF18044.1 ADV20753.1 - 1.1e-09 37.9 6.6 8.3e-05 22.3 0.6 2.3 2 0 0 2 2 2 2 CCCH-type zinc finger Torus PF16131.5 ADV20753.1 - 1.9e-08 35.0 5.9 5.9e-05 23.7 0.5 2.4 1 1 1 2 2 2 2 Torus domain zf-CCCH PF00642.24 ADV20753.1 - 1.9e-07 30.8 10.1 0.00011 22.0 1.9 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 ADV20753.1 - 1.1e-06 28.4 14.2 9.2e-06 25.5 2.0 2.4 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH_3 PF15663.5 ADV20753.1 - 4.3e-05 23.7 0.9 7.8e-05 22.9 0.9 1.3 1 0 0 1 1 1 1 Zinc-finger containing family zf-CCCH_2 PF14608.6 ADV20753.1 - 0.0016 18.9 2.0 0.0016 18.9 2.0 2.4 2 0 0 2 2 2 1 RNA-binding, Nab2-type zinc finger OPA3 PF07047.12 ADV20754.1 - 2.7e-43 146.7 0.4 3.8e-43 146.2 0.4 1.2 1 0 0 1 1 1 1 Optic atrophy 3 protein (OPA3) ABC_tran_CTD PF16326.5 ADV20754.1 - 0.00061 20.0 1.6 0.0012 19.1 1.6 1.4 1 0 0 1 1 1 1 ABC transporter C-terminal domain DUF3037 PF11236.8 ADV20754.1 - 0.005 17.3 0.6 0.044 14.2 0.1 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF3037) BLOC1_2 PF10046.9 ADV20754.1 - 0.071 13.4 1.2 0.16 12.3 1.2 1.5 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Noelin-1 PF12308.8 ADV20754.1 - 0.087 12.8 0.8 0.18 11.8 0.8 1.5 1 0 0 1 1 1 0 Neurogenesis glycoprotein Prefoldin_2 PF01920.20 ADV20754.1 - 0.1 12.5 4.3 0.17 11.9 3.9 1.6 1 1 0 1 1 1 0 Prefoldin subunit Cauli_AT PF03233.13 ADV20754.1 - 0.12 12.3 1.4 0.2 11.5 1.4 1.3 1 0 0 1 1 1 0 Aphid transmission protein TraF_2 PF13729.6 ADV20754.1 - 0.15 11.5 0.1 0.22 10.9 0.1 1.2 1 0 0 1 1 1 0 F plasmid transfer operon, TraF, protein RBD-FIP PF09457.10 ADV20754.1 - 0.54 10.2 2.9 0.91 9.5 2.9 1.4 1 0 0 1 1 1 0 FIP domain DUF4391 PF14335.6 ADV20754.1 - 3.1 7.5 5.4 23 4.6 5.4 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4391) Pkinase PF00069.25 ADV20755.1 - 1.9e-65 220.9 0.0 2.3e-65 220.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV20755.1 - 1.2e-31 110.0 0.0 1.5e-31 109.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 ADV20755.1 - 1.3e-05 24.4 0.0 1.8e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 ADV20755.1 - 9.6e-05 21.8 0.1 0.00031 20.1 0.1 1.7 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ADV20755.1 - 0.0006 19.8 0.0 0.0013 18.7 0.0 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 ADV20755.1 - 0.012 14.9 0.0 0.052 12.9 0.0 1.8 1 1 1 2 2 2 0 Kinase-like FTA2 PF13095.6 ADV20755.1 - 0.014 15.0 0.0 0.023 14.3 0.0 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 ADV20755.1 - 0.032 13.8 0.0 0.048 13.2 0.0 1.3 1 0 0 1 1 1 0 RIO1 family Exo_endo_phos PF03372.23 ADV20756.1 - 1.7e-10 40.8 0.1 3.7e-10 39.7 0.1 1.4 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family V-ATPase_C PF03223.15 ADV20757.1 - 3.5e-116 388.7 0.0 3.9e-116 388.5 0.0 1.0 1 0 0 1 1 1 1 V-ATPase subunit C HTH_37 PF13744.6 ADV20757.1 - 0.11 12.5 2.5 0.11 12.4 0.3 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain ADH_N PF08240.12 ADV20758.1 - 1.4e-23 82.9 0.7 3e-23 81.8 0.7 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ADV20758.1 - 7e-13 48.7 0.0 8.8e-08 32.2 0.0 2.3 2 0 0 2 2 2 2 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 ADV20758.1 - 3e-06 26.9 0.2 0.003 17.1 0.2 2.4 2 0 0 2 2 2 2 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 ADV20758.1 - 0.00032 21.7 0.0 0.00072 20.6 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase UDPG_MGDP_dh_N PF03721.14 ADV20758.1 - 0.013 15.1 0.0 0.022 14.3 0.0 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 2-Hacid_dh_C PF02826.19 ADV20758.1 - 0.031 13.6 0.0 0.068 12.5 0.0 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain MTS PF05175.14 ADV20758.1 - 0.048 13.2 0.0 0.089 12.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain CGI-121 PF08617.10 ADV20759.1 - 1.8e-47 161.5 0.0 2.3e-47 161.2 0.0 1.1 1 0 0 1 1 1 1 Kinase binding protein CGI-121 Tti2 PF10521.9 ADV20760.1 - 4.1e-32 111.8 0.0 1.2e-31 110.3 0.0 1.7 2 0 0 2 2 2 1 Tti2 family ChaC PF04752.12 ADV20761.1 - 3e-42 144.7 0.0 3.7e-42 144.4 0.0 1.1 1 0 0 1 1 1 1 ChaC-like protein MFS_1 PF07690.16 ADV20762.1 - 2.2e-13 49.8 25.4 2.2e-12 46.6 14.9 2.3 2 0 0 2 2 2 2 Major Facilitator Superfamily DUF4131 PF13567.6 ADV20762.1 - 0.006 16.3 3.2 0.028 14.1 0.3 2.9 3 0 0 3 3 3 1 Domain of unknown function (DUF4131) DUF1127 PF06568.11 ADV20762.1 - 0.052 13.3 0.1 0.11 12.2 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1127) MFS_1 PF07690.16 ADV20763.1 - 6.1e-44 150.4 39.3 6.1e-44 150.4 39.3 1.9 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ADV20763.1 - 1.1e-08 34.4 5.6 1.1e-08 34.4 5.6 3.4 3 1 1 4 4 4 2 Sugar (and other) transporter TRI12 PF06609.13 ADV20763.1 - 8.4e-06 24.5 12.7 8.4e-06 24.5 12.7 1.3 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_1_like PF12832.7 ADV20763.1 - 7.8e-05 21.7 12.4 0.0078 15.1 8.4 2.7 2 1 0 2 2 2 2 MFS_1 like family Ank_4 PF13637.6 ADV20765.1 - 0.0023 18.5 0.4 0.14 12.8 0.1 2.9 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 ADV20765.1 - 0.0026 18.1 0.2 0.025 15.0 0.0 2.7 3 2 0 3 3 3 1 Ankyrin repeat Ank_2 PF12796.7 ADV20765.1 - 0.0029 18.1 0.0 0.0063 17.1 0.0 1.6 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ADV20765.1 - 0.0084 16.4 0.1 7.2 7.1 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ADV20765.1 - 0.034 14.7 0.0 0.14 12.8 0.0 2.1 1 1 0 1 1 1 0 Ankyrin repeat FAD-oxidase_C PF02913.19 ADV20766.1 - 5.3e-57 193.3 0.0 8e-57 192.7 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 ADV20766.1 - 2.5e-34 118.0 0.0 4.6e-34 117.1 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain zf-C3HC4_2 PF13923.6 ADV20767.1 - 0.015 15.1 1.0 0.025 14.4 1.0 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ADV20767.1 - 0.093 12.6 0.5 0.16 11.9 0.5 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ADV20767.1 - 0.14 12.6 1.7 0.24 11.8 1.7 1.4 1 0 0 1 1 1 0 Ring finger domain Ribosomal_L11_N PF03946.14 ADV20768.1 - 1.3e-24 85.8 0.1 1.9e-24 85.3 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 ADV20768.1 - 1.1e-17 64.3 0.1 1.9e-17 63.5 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain DUF775 PF05603.12 ADV20770.1 - 1.1e-52 178.5 0.0 1.2e-52 178.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF775) Aminotran_1_2 PF00155.21 ADV20771.1 - 9.1e-53 179.7 0.0 9.2e-43 146.8 0.0 2.2 2 0 0 2 2 2 2 Aminotransferase class I and II OKR_DC_1 PF01276.20 ADV20771.1 - 0.00043 19.1 0.0 0.0014 17.4 0.0 1.7 2 0 0 2 2 2 1 Orn/Lys/Arg decarboxylase, major domain Aminotran_5 PF00266.19 ADV20771.1 - 0.0049 15.9 0.0 0.0081 15.1 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 ADV20771.1 - 0.016 14.5 0.0 0.17 11.2 0.0 2.1 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 ADV20771.1 - 0.11 11.0 0.0 0.22 10.0 0.0 1.4 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme CMAS PF02353.20 ADV20772.1 - 4.3e-68 229.6 0.3 5.5e-68 229.2 0.3 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_25 PF13649.6 ADV20772.1 - 1.6e-11 44.7 0.0 7.3e-11 42.6 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 ADV20772.1 - 6.1e-11 42.8 0.0 7.6e-10 39.3 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 ADV20772.1 - 2.7e-09 37.1 0.0 4.9e-09 36.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ADV20772.1 - 3e-05 24.7 0.0 7.2e-05 23.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ADV20772.1 - 0.00069 19.2 0.0 0.0012 18.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain DOT1 PF08123.13 ADV20772.1 - 0.0062 16.1 0.0 0.013 15.1 0.0 1.4 1 0 0 1 1 1 1 Histone methylation protein DOT1 PCMT PF01135.19 ADV20772.1 - 0.013 15.2 0.0 0.022 14.5 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 ADV20772.1 - 0.024 14.4 0.1 0.079 12.7 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain DUF2315 PF10231.9 ADV20772.1 - 0.2 11.7 1.5 1.3 9.1 0.5 2.3 2 0 0 2 2 2 0 Apoptogenic protein 1 Sulfate_transp PF00916.20 ADV20775.1 - 3.5e-84 282.7 17.3 3.5e-84 282.7 17.3 1.4 2 0 0 2 2 2 1 Sulfate permease family STAS PF01740.21 ADV20775.1 - 3.2e-16 59.0 0.0 6.5e-16 58.0 0.0 1.5 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.6 ADV20775.1 - 0.0094 16.3 0.0 0.026 14.9 0.0 1.8 1 0 0 1 1 1 1 STAS domain 2Fe-2S_thioredx PF01257.19 ADV20776.1 - 2.5e-56 189.5 0.0 3.1e-56 189.3 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin MAP65_ASE1 PF03999.12 ADV20777.1 - 1.6e-61 208.8 13.8 2.1e-60 205.1 13.8 2.4 1 1 0 1 1 1 1 Microtubule associated protein (MAP65/ASE1 family) DUF3818 PF12825.7 ADV20777.1 - 0.025 13.6 0.1 2.1 7.3 0.1 2.5 2 1 0 2 2 2 0 Domain of unknown function in PX-proteins (DUF3818) Exonuc_VII_L PF02601.15 ADV20777.1 - 3 7.3 10.7 0.67 9.5 3.1 2.3 2 0 0 2 2 2 0 Exonuclease VII, large subunit DUF1664 PF07889.12 ADV20777.1 - 3.1 7.9 6.7 0.37 10.8 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) DUF4407 PF14362.6 ADV20777.1 - 7.2 5.9 12.8 30 3.9 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4407) DUF5082 PF16888.5 ADV20777.1 - 8.5 6.7 8.7 29 5.0 0.2 3.5 2 1 1 3 3 3 0 Domain of unknown function (DUF5082) Fib_alpha PF08702.10 ADV20777.1 - 8.5 6.6 10.9 11 6.2 2.9 3.4 2 1 2 4 4 4 0 Fibrinogen alpha/beta chain family MIF4G_like_2 PF09090.11 ADV20777.1 - 8.7 5.7 7.7 2.8 7.3 3.2 2.4 2 0 0 2 2 2 0 MIF4G like DUF563 PF04577.14 ADV20778.1 - 6.2e-09 36.3 0.0 1.3e-08 35.2 0.0 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF563) XPG_I PF00867.18 ADV20780.1 - 7.6e-12 45.4 0.0 1.7e-11 44.3 0.0 1.6 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 ADV20780.1 - 3.9e-07 30.5 0.0 8.3e-07 29.4 0.0 1.6 1 0 0 1 1 1 1 XPG N-terminal domain 5_3_exonuc PF01367.20 ADV20780.1 - 0.028 15.0 0.1 0.096 13.3 0.0 2.0 2 0 0 2 2 2 0 5'-3' exonuclease, C-terminal SAM fold PdxA PF04166.12 ADV20781.1 - 0.098 12.0 0.1 0.13 11.7 0.1 1.1 1 0 0 1 1 1 0 Pyridoxal phosphate biosynthetic protein PdxA NAD_binding_1 PF00175.21 ADV20782.1 - 3.6e-09 37.2 0.0 8.7e-09 36.0 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Globin PF00042.22 ADV20782.1 - 1.4e-07 32.0 0.5 1.7e-06 28.5 0.2 2.2 2 0 0 2 2 2 1 Globin FAD_binding_6 PF00970.24 ADV20782.1 - 3.6e-06 27.2 0.0 7.4e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 ADV20782.1 - 0.00014 22.0 0.0 0.035 14.2 0.0 2.9 2 1 1 3 3 3 1 Ferric reductase NAD binding domain Protoglobin PF11563.8 ADV20782.1 - 0.0018 18.2 0.4 0.0038 17.1 0.4 1.5 1 1 0 1 1 1 1 Protoglobin OmpH PF03938.14 ADV20783.1 - 0.083 13.2 8.0 0.16 12.3 5.1 2.1 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) FAM76 PF16046.5 ADV20783.1 - 0.1 11.9 4.7 0.12 11.7 4.7 1.0 1 0 0 1 1 1 0 FAM76 protein DUF3287 PF11690.8 ADV20783.1 - 0.11 12.2 4.5 0.17 11.6 4.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3287) CALM_bind PF16025.5 ADV20783.1 - 2.7 8.5 9.4 0.47 11.0 0.5 2.5 1 1 1 2 2 2 0 Calcium-dependent calmodulin binding Vps54 PF07928.12 ADV20784.1 - 2.3e-43 147.9 0.4 1e-42 145.7 0.0 2.4 2 0 0 2 2 2 1 Vps54-like protein DUF2451 PF10474.9 ADV20784.1 - 0.026 14.3 0.1 0.065 13.0 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function C-terminus (DUF2451) SBF_like PF13593.6 ADV20785.1 - 2.9e-90 302.8 11.4 3.5e-90 302.5 11.4 1.1 1 0 0 1 1 1 1 SBF-like CPA transporter family (DUF4137) ETRAMP PF09716.10 ADV20785.1 - 0.063 13.3 0.0 0.85 9.7 0.0 2.6 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Cadherin_C_2 PF16492.5 ADV20785.1 - 0.4 11.4 1.8 3.5 8.4 0.1 2.7 2 0 0 2 2 2 0 Cadherin cytoplasmic C-terminal FAA_hydrolase PF01557.18 ADV20786.1 - 1.7e-39 135.8 0.1 6.1e-21 75.1 0.0 2.1 1 1 1 2 2 2 2 Fumarylacetoacetate (FAA) hydrolase family KH_2 PF07650.17 ADV20786.1 - 0.17 11.7 0.3 0.28 11.0 0.3 1.3 1 0 0 1 1 1 0 KH domain RhoGAP PF00620.27 ADV20787.1 - 8.9e-31 106.8 0.0 1.4e-30 106.1 0.0 1.2 1 0 0 1 1 1 1 RhoGAP domain Gram_pos_anchor PF00746.21 ADV20788.1 - 0.041 13.8 0.2 0.089 12.7 0.2 1.6 1 0 0 1 1 1 0 LPXTG cell wall anchor motif DUF2105 PF09878.9 ADV20788.1 - 0.09 12.5 0.0 0.097 12.4 0.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2105) DEAD PF00270.29 ADV20789.1 - 5.6e-42 143.5 0.1 8.7e-42 142.9 0.1 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ADV20789.1 - 7.7e-27 93.8 0.9 1.6e-26 92.8 0.4 1.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Lactonase PF10282.9 ADV20790.1 - 2e-53 181.9 0.0 2.5e-53 181.5 0.0 1.0 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller Adaptin_N PF01602.20 ADV20791.1 - 1.4e-89 301.0 0.0 4.8e-88 296.0 0.0 2.0 1 1 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 ADV20791.1 - 1.1e-12 48.3 0.0 3.2e-11 43.5 0.0 2.5 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 ADV20791.1 - 2.5e-08 34.2 2.1 0.0013 19.1 0.0 3.9 3 2 0 3 3 3 2 HEAT repeats HEAT PF02985.22 ADV20791.1 - 4.7e-06 26.4 4.7 2 8.9 0.0 5.9 7 0 0 7 7 7 2 HEAT repeat HEAT_EZ PF13513.6 ADV20791.1 - 0.0025 18.3 1.2 5.8 7.5 0.1 4.8 4 1 1 5 5 5 1 HEAT-like repeat Arm PF00514.23 ADV20791.1 - 1.6 8.9 6.4 2.8 8.1 0.2 3.9 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat MFS_1 PF07690.16 ADV20792.1 - 1.3e-26 93.4 19.4 6.7e-23 81.2 13.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ADV20792.1 - 1.1e-07 31.1 5.3 6.3e-07 28.6 5.3 2.1 1 1 0 1 1 1 1 Sugar (and other) transporter TRI12 PF06609.13 ADV20792.1 - 9.1e-05 21.1 0.8 0.00016 20.3 0.8 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) WD40 PF00400.32 ADV20793.1 - 6.7e-24 83.7 28.1 0.018 15.9 0.0 10.8 12 0 0 12 12 12 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV20793.1 - 3e-20 72.3 0.3 4e-07 30.2 0.0 6.7 4 3 3 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain RAB3GAP2_N PF14655.6 ADV20793.1 - 4.6e-06 26.2 0.0 0.00029 20.2 0.0 2.5 3 0 0 3 3 3 1 Rab3 GTPase-activating protein regulatory subunit N-terminus Ge1_WD40 PF16529.5 ADV20793.1 - 0.0052 15.8 6.6 7.6 5.4 0.0 5.1 6 1 1 7 7 7 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ADV20793.1 - 0.16 11.9 1.8 1.2e+02 2.8 0.0 4.9 4 1 0 4 4 4 0 WD40-like Beta Propeller Repeat DUF3449 PF11931.8 ADV20794.1 - 2.4e-68 229.6 0.4 8.1e-68 227.8 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3449) SF3A3 PF16837.5 ADV20794.1 - 1.6e-22 79.8 3.7 5.2e-20 71.7 3.2 2.6 2 0 0 2 2 2 1 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 zf-C2H2_jaz PF12171.8 ADV20794.1 - 4.2e-10 39.6 9.2 1.8e-07 31.3 1.6 3.4 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding SF3a60_bindingd PF12108.8 ADV20794.1 - 3e-08 33.4 0.1 6.5e-08 32.3 0.1 1.5 1 0 0 1 1 1 1 Splicing factor SF3a60 binding domain zf-met PF12874.7 ADV20794.1 - 7.4e-08 32.5 6.6 0.0021 18.4 1.7 2.9 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 ADV20794.1 - 2.1e-05 24.8 0.4 0.0076 16.6 0.1 2.7 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 ADV20794.1 - 0.0023 18.6 2.7 2.2 9.3 0.2 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger DUF1178 PF06676.11 ADV20794.1 - 0.047 14.1 1.5 0.069 13.5 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1178) zf-DBF PF07535.12 ADV20794.1 - 0.83 9.8 5.5 3 8.0 0.3 2.6 2 0 0 2 2 2 0 DBF zinc finger zf-C2H2 PF00096.26 ADV20794.1 - 6 7.5 6.5 15 6.3 0.7 2.5 2 0 0 2 2 2 0 Zinc finger, C2H2 type Ribo_biogen_C PF04034.13 ADV20795.1 - 1.1e-55 186.7 0.0 1.8e-55 186.0 0.0 1.3 1 0 0 1 1 1 1 Ribosome biogenesis protein, C-terminal RLI PF04068.15 ADV20795.1 - 4.7e-15 55.1 0.1 8.2e-15 54.3 0.1 1.4 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI Serglycin PF04360.12 ADV20795.1 - 0.0087 16.0 0.9 0.015 15.2 0.9 1.4 1 0 0 1 1 1 1 Serglycin Cwf_Cwc_15 PF04889.12 ADV20795.1 - 3.7 7.2 29.9 0.26 11.0 10.7 2.1 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Use1 PF09753.9 ADV20796.1 - 0.0012 18.7 0.1 0.0014 18.5 0.1 1.0 1 0 0 1 1 1 1 Membrane fusion protein Use1 SNARE PF05739.19 ADV20796.1 - 0.0012 18.7 0.0 0.0017 18.3 0.0 1.2 1 0 0 1 1 1 1 SNARE domain Sec20 PF03908.13 ADV20796.1 - 0.027 14.4 0.0 0.034 14.0 0.0 1.3 1 0 0 1 1 1 0 Sec20 BatD PF13584.6 ADV20796.1 - 0.2 10.4 0.2 0.2 10.4 0.2 1.1 1 0 0 1 1 1 0 Oxygen tolerance CHORD PF04968.12 ADV20797.1 - 5.9e-49 164.6 16.4 2.2e-25 89.1 4.7 2.2 2 0 0 2 2 2 2 CHORD CS PF04969.16 ADV20797.1 - 3.7e-15 56.7 0.0 7e-15 55.8 0.0 1.5 1 0 0 1 1 1 1 CS domain MSP1a PF11670.8 ADV20797.1 - 0.08 12.2 4.4 0.13 11.5 4.4 1.2 1 0 0 1 1 1 0 Major surface protein 1a (MSP1a) BTK PF00779.19 ADV20797.1 - 0.52 10.2 15.9 0.33 10.8 4.1 3.3 2 2 0 2 2 2 0 BTK motif DUF3682 PF12446.8 ADV20797.1 - 4.2 7.8 9.5 9.1 6.8 9.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) DDE_Tnp_4 PF13359.6 ADV20798.1 - 8.8e-10 38.5 0.0 1.3e-09 37.9 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease EF-hand_1 PF00036.32 ADV20799.1 - 1.7e-39 130.4 14.3 1.2e-09 37.1 0.1 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 ADV20799.1 - 3.5e-33 113.9 3.1 3.2e-17 62.7 0.5 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ADV20799.1 - 5e-30 100.9 8.4 1.3e-09 37.2 0.1 4.6 4 1 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 ADV20799.1 - 9.9e-30 102.2 12.7 2.3e-13 49.8 0.5 4.0 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 ADV20799.1 - 5.5e-27 92.0 10.1 1.6e-07 30.5 0.0 4.2 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 ADV20799.1 - 1.2e-14 54.3 0.2 4.4e-08 33.3 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.9 ADV20799.1 - 1.2e-09 38.5 0.7 8.2e-05 22.9 0.1 2.1 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 ADV20799.1 - 1.8e-09 37.5 1.8 6.9e-05 22.7 0.2 2.2 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand UPF0154 PF03672.13 ADV20799.1 - 4.5e-05 23.4 0.0 0.11 12.6 0.0 2.8 2 1 1 3 3 3 2 Uncharacterised protein family (UPF0154) TerB PF05099.13 ADV20799.1 - 6.6e-05 22.9 0.4 0.14 12.1 0.1 2.3 2 1 0 2 2 2 2 Tellurite resistance protein TerB Caleosin PF05042.13 ADV20799.1 - 0.0001 22.3 3.0 0.78 9.6 0.0 3.6 1 1 3 4 4 4 2 Caleosin related protein DUF3349 PF11829.8 ADV20799.1 - 0.00015 22.5 0.5 3 8.7 0.0 3.0 1 1 2 3 3 3 1 Protein of unknown function (DUF3349) EFhand_Ca_insen PF08726.10 ADV20799.1 - 0.00047 20.2 1.5 0.0023 18.0 0.1 2.4 2 1 0 2 2 2 1 Ca2+ insensitive EF hand EF-hand_14 PF17959.1 ADV20799.1 - 0.00052 20.3 0.2 0.35 11.2 0.0 2.3 1 1 1 2 2 2 2 EF-hand domain DUF4497 PF14924.6 ADV20799.1 - 0.00075 19.9 0.0 0.51 10.8 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF4497) Dockerin_1 PF00404.18 ADV20799.1 - 0.0037 17.4 6.0 0.25 11.6 0.7 3.1 1 1 3 4 4 4 2 Dockerin type I domain DUF2267 PF10025.9 ADV20799.1 - 0.0055 17.0 0.0 0.014 15.7 0.0 1.6 1 1 1 2 2 2 1 Uncharacterized conserved protein (DUF2267) MotA_activ PF09114.10 ADV20799.1 - 0.0062 16.6 0.5 0.096 12.8 0.1 2.3 1 1 0 2 2 2 1 Transcription factor MotA, activation domain RNA_pol_Rpb4 PF03874.16 ADV20799.1 - 0.011 16.0 1.0 3.1 8.1 0.6 2.8 1 1 0 2 2 2 0 RNA polymerase Rpb4 DUF1811 PF08838.10 ADV20799.1 - 0.031 14.5 0.4 11 6.4 0.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1811) MecA_N PF05223.11 ADV20799.1 - 0.033 14.5 0.6 0.15 12.3 0.1 1.9 1 1 1 2 2 2 0 NTF2-like N-terminal transpeptidase domain FGAR-AT_linker PF18072.1 ADV20799.1 - 0.039 14.5 0.2 8 7.1 0.0 2.6 2 1 0 2 2 2 0 Formylglycinamide ribonucleotide amidotransferase linker domain SurA_N_2 PF13623.6 ADV20799.1 - 0.041 13.7 0.6 0.78 9.6 0.1 2.3 1 1 1 2 2 2 0 SurA N-terminal domain T3SS_HrpK1 PF16937.5 ADV20799.1 - 0.044 13.4 0.4 0.94 9.1 0.0 2.0 1 1 0 2 2 2 0 Type III secretion system translocator protein, HrpF EF-hand_11 PF08976.11 ADV20799.1 - 0.067 14.1 0.1 0.75 10.7 0.0 2.0 1 1 1 2 2 2 0 EF-hand domain DUF1103 PF06513.11 ADV20799.1 - 0.073 12.7 3.2 0.093 12.3 3.2 1.3 1 0 0 1 1 1 0 Repeat of unknown function (DUF1103) SapB_1 PF05184.15 ADV20799.1 - 0.086 12.9 2.8 2.7 8.1 0.0 3.5 4 0 0 4 4 4 0 Saposin-like type B, region 1 DUF5580 PF17743.1 ADV20799.1 - 0.087 11.4 0.0 0.34 9.4 0.0 1.6 1 1 1 2 2 2 0 Family of unknown function (DUF5580) Amdo_NSP PF12475.8 ADV20799.1 - 0.11 12.6 0.0 1.5 9.0 0.0 2.3 2 0 0 2 2 2 0 Amdovirus non-structural protein Fe_hyd_lg_C PF02906.14 ADV20799.1 - 0.15 11.7 1.7 1 8.9 1.7 2.1 1 1 0 1 1 1 0 Iron only hydrogenase large subunit, C-terminal domain ADH_N PF08240.12 ADV20800.1 - 4e-29 100.7 1.1 6.9e-29 99.9 1.1 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ADV20800.1 - 9.7e-16 57.9 0.0 1.5e-15 57.3 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 ADV20800.1 - 4.7e-12 45.9 0.0 6.7e-12 45.3 0.0 1.2 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 ADV20800.1 - 5.5e-06 27.5 0.0 1e-05 26.6 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase FAD_binding_3 PF01494.19 ADV20800.1 - 0.0039 16.5 1.9 0.0057 16.0 1.9 1.2 1 0 0 1 1 1 1 FAD binding domain Shikimate_DH PF01488.20 ADV20800.1 - 0.038 14.1 0.0 0.066 13.3 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase ThiF PF00899.21 ADV20800.1 - 0.067 12.5 0.4 0.14 11.5 0.4 1.5 2 0 0 2 2 2 0 ThiF family NADH_4Fe-4S PF10589.9 ADV20800.1 - 0.12 12.5 0.4 0.21 11.6 0.4 1.5 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region Staph_opine_DH PF10100.9 ADV20800.1 - 0.2 10.3 0.0 0.3 9.7 0.0 1.3 1 0 0 1 1 1 0 Staphylopine dehydrogenase WD40 PF00400.32 ADV20801.1 - 2.2e-28 97.9 23.6 7.7e-08 32.9 1.3 6.3 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV20801.1 - 4.9e-13 49.2 0.6 0.00048 20.4 0.1 5.2 3 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain LisH_TPL PF17814.1 ADV20801.1 - 0.00053 19.6 0.0 0.001 18.7 0.0 1.4 1 0 0 1 1 1 1 LisH-like dimerisation domain eIF2A PF08662.11 ADV20801.1 - 0.00061 19.7 0.0 1.7 8.5 0.0 3.1 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ADV20801.1 - 0.0017 18.2 1.4 4.5 7.3 0.1 3.8 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat Gmad1 PF10647.9 ADV20801.1 - 0.0038 17.0 0.5 0.027 14.2 0.0 2.4 3 0 0 3 3 3 1 Lipoprotein LpqB beta-propeller domain Ge1_WD40 PF16529.5 ADV20801.1 - 0.04 12.9 0.1 0.26 10.2 0.1 2.3 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein DPPIV_N PF00930.21 ADV20801.1 - 0.12 11.1 0.2 2.2 7.0 0.0 2.8 2 1 1 3 3 3 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region DUF4888 PF16229.5 ADV20801.1 - 0.31 11.0 1.2 1.2 9.1 0.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4888) DPBB_1 PF03330.18 ADV20802.1 - 6.3e-09 36.0 0.4 3.6e-08 33.6 0.4 2.4 1 1 0 1 1 1 1 Lytic transglycolase Barwin PF00967.17 ADV20802.1 - 7.7e-05 22.5 0.8 7.7e-05 22.5 0.8 1.9 2 0 0 2 2 2 1 Barwin family Rrn6 PF10214.9 ADV20802.1 - 0.027 13.0 9.8 0.028 12.9 9.8 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Apt1 PF10351.9 ADV20802.1 - 0.24 10.2 13.1 0.27 10.0 13.1 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Macoilin PF09726.9 ADV20802.1 - 0.35 9.4 16.4 0.4 9.2 16.4 1.1 1 0 0 1 1 1 0 Macoilin family SAPS PF04499.15 ADV20802.1 - 0.46 9.2 5.3 0.59 8.9 5.3 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Ins_beta PF03488.14 ADV20802.1 - 0.55 10.3 3.0 8.4 6.5 0.1 3.4 3 1 0 3 3 3 0 Nematode insulin-related peptide beta type SPX PF03105.19 ADV20802.1 - 0.56 10.1 13.2 0.65 9.9 13.2 1.1 1 0 0 1 1 1 0 SPX domain SOBP PF15279.6 ADV20802.1 - 0.81 10.2 5.3 1.1 9.8 5.3 1.4 1 0 0 1 1 1 0 Sine oculis-binding protein Presenilin PF01080.17 ADV20802.1 - 1.1 7.9 9.9 1.3 7.7 9.9 1.2 1 0 0 1 1 1 0 Presenilin Utp14 PF04615.13 ADV20802.1 - 1.4 7.4 11.6 1.7 7.1 11.6 1.0 1 0 0 1 1 1 0 Utp14 protein SWI-SNF_Ssr4 PF08549.10 ADV20802.1 - 2.3 6.8 11.4 2.7 6.5 11.4 1.2 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) DUF572 PF04502.13 ADV20802.1 - 2.4 7.7 9.7 3.3 7.3 9.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) PAP1 PF08601.10 ADV20802.1 - 2.9 7.5 26.5 4.5 6.9 26.5 1.4 1 0 0 1 1 1 0 Transcription factor PAP1 GREB1 PF15782.5 ADV20802.1 - 3.9 4.5 19.0 4.7 4.2 19.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Plasmodium_Vir PF05795.11 ADV20802.1 - 4.9 6.5 10.1 7.7 5.8 10.1 1.3 1 0 0 1 1 1 0 Plasmodium vivax Vir protein BUD22 PF09073.10 ADV20802.1 - 5.5 6.2 17.8 7.3 5.8 17.8 1.1 1 0 0 1 1 1 0 BUD22 RRM_1 PF00076.22 ADV20803.1 - 4.8e-10 39.1 0.0 6.6e-05 22.7 0.0 4.7 4 0 0 4 4 4 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_Rrp7 PF17799.1 ADV20803.1 - 0.00056 19.7 0.0 0.025 14.4 0.0 2.8 2 1 0 2 2 2 1 Rrp7 RRM-like N-terminal domain BPL_N PF09825.9 ADV20804.1 - 1.1e-99 334.1 0.0 1.3e-99 333.8 0.0 1.1 1 0 0 1 1 1 1 Biotin-protein ligase, N terminal BPL_LplA_LipB PF03099.19 ADV20804.1 - 8.1e-20 71.1 0.0 1.3e-19 70.4 0.0 1.3 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family GATase_3 PF07685.14 ADV20804.1 - 1.9e-05 24.4 0.0 3.3e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain DJ-1_PfpI PF01965.24 ADV20804.1 - 0.019 14.7 0.0 0.035 13.9 0.0 1.4 1 0 0 1 1 1 0 DJ-1/PfpI family DUF1688 PF07958.11 ADV20805.1 - 4.1e-149 496.9 0.0 4.6e-149 496.7 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1688) TIM21 PF08294.11 ADV20806.1 - 1.3e-11 44.6 0.0 4e-11 43.0 0.0 1.8 2 0 0 2 2 2 1 TIM21 7TM-7TMR_HD PF07698.11 ADV20807.1 - 0.13 12.0 0.0 0.17 11.6 0.0 1.1 1 0 0 1 1 1 0 7TM receptor with intracellular HD hydrolase DUF485 PF04341.12 ADV20807.1 - 0.17 11.9 0.4 0.29 11.1 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF485 Rhodanese PF00581.20 ADV20808.1 - 4.1e-12 46.6 0.0 7.4e-12 45.7 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain ABC_membrane PF00664.23 ADV20810.1 - 2e-51 175.2 29.8 9.1e-27 94.4 7.1 3.3 3 0 0 3 3 3 3 ABC transporter transmembrane region ABC_tran PF00005.27 ADV20810.1 - 5.2e-48 163.0 0.1 6e-30 104.6 0.1 2.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 ADV20810.1 - 2.5e-12 46.7 0.2 0.046 13.2 0.0 4.3 3 1 1 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ADV20810.1 - 3.6e-08 33.0 2.0 0.00095 18.9 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.6 ADV20810.1 - 4.8e-08 33.2 7.5 0.0039 17.0 0.2 4.3 2 2 1 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 ADV20810.1 - 1.1e-07 32.3 0.3 0.013 15.7 0.0 3.1 2 1 0 2 2 2 2 AAA domain T2SSE PF00437.20 ADV20810.1 - 3e-07 29.8 0.2 0.0093 15.1 0.0 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein MMR_HSR1 PF01926.23 ADV20810.1 - 9.7e-06 25.7 0.3 0.11 12.6 0.2 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_18 PF13238.6 ADV20810.1 - 1.2e-05 25.9 0.0 0.14 12.7 0.0 3.5 3 0 0 3 3 2 2 AAA domain AAA_16 PF13191.6 ADV20810.1 - 1.3e-05 25.7 0.4 0.2 12.0 0.0 3.0 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 ADV20810.1 - 1.3e-05 25.2 0.1 0.016 15.1 0.0 2.6 2 0 0 2 2 2 1 RsgA GTPase ATPase_2 PF01637.18 ADV20810.1 - 3.6e-05 23.8 0.0 0.00057 19.9 0.0 2.6 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea AAA_7 PF12775.7 ADV20810.1 - 6.4e-05 22.5 0.4 0.45 10.0 0.1 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region DUF87 PF01935.17 ADV20810.1 - 8.3e-05 22.8 2.8 0.044 13.9 0.4 2.5 2 0 0 2 2 2 2 Helicase HerA, central domain AAA_23 PF13476.6 ADV20810.1 - 0.00012 22.7 16.1 0.16 12.4 11.7 3.3 2 1 0 2 2 2 2 AAA domain FtsK_SpoIIIE PF01580.18 ADV20810.1 - 0.00079 18.9 0.1 0.54 9.6 0.0 2.4 2 0 0 2 2 2 1 FtsK/SpoIIIE family RNA_helicase PF00910.22 ADV20810.1 - 0.0008 19.8 0.0 0.28 11.6 0.0 2.7 2 0 0 2 2 2 1 RNA helicase AAA PF00004.29 ADV20810.1 - 0.0018 18.7 0.0 1.1 9.6 0.0 3.0 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 ADV20810.1 - 0.0019 17.9 0.7 0.4 10.4 0.0 2.9 3 0 0 3 3 3 1 AAA domain AAA_33 PF13671.6 ADV20810.1 - 0.003 17.7 0.5 2.5 8.3 0.0 3.1 3 0 0 3 3 2 1 AAA domain NTPase_1 PF03266.15 ADV20810.1 - 0.0036 17.2 0.3 2 8.3 0.2 2.5 2 0 0 2 2 2 1 NTPase Adeno_IVa2 PF02456.15 ADV20810.1 - 0.004 16.0 0.1 0.02 13.7 0.0 2.0 2 0 0 2 2 2 1 Adenovirus IVa2 protein Zeta_toxin PF06414.12 ADV20810.1 - 0.005 16.1 0.5 1.6 7.9 0.0 2.3 2 0 0 2 2 2 1 Zeta toxin ResIII PF04851.15 ADV20810.1 - 0.0083 16.1 0.1 3 7.8 0.0 3.2 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit DUF815 PF05673.13 ADV20810.1 - 0.0095 15.1 0.1 1.1 8.3 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_28 PF13521.6 ADV20810.1 - 0.0098 16.1 0.2 0.28 11.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 ADV20810.1 - 0.01 15.8 0.2 0.3 11.1 0.0 2.9 3 0 0 3 3 3 0 AAA domain AAA_25 PF13481.6 ADV20810.1 - 0.011 15.3 0.9 2.4 7.7 0.1 2.6 2 0 0 2 2 2 0 AAA domain AAA_15 PF13175.6 ADV20810.1 - 0.012 15.4 0.1 4.6 6.8 0.0 2.5 2 0 0 2 2 2 0 AAA ATPase domain NACHT PF05729.12 ADV20810.1 - 0.012 15.5 7.0 0.95 9.4 0.0 4.2 4 0 0 4 4 4 0 NACHT domain IstB_IS21 PF01695.17 ADV20810.1 - 0.017 14.8 0.7 3.7 7.2 0.0 2.8 3 0 0 3 3 3 0 IstB-like ATP binding protein Sigma54_activat PF00158.26 ADV20810.1 - 0.018 14.7 0.1 3 7.5 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_5 PF07728.14 ADV20810.1 - 0.03 14.3 2.1 4.8 7.2 0.2 3.7 4 0 0 4 4 3 0 AAA domain (dynein-related subfamily) APS_kinase PF01583.20 ADV20810.1 - 0.036 14.0 0.2 3.8 7.4 0.1 2.4 2 0 0 2 2 2 0 Adenylylsulphate kinase DEAD PF00270.29 ADV20810.1 - 0.042 13.6 0.3 15 5.3 0.1 3.3 3 0 0 3 3 3 0 DEAD/DEAH box helicase Mg_chelatase PF01078.21 ADV20810.1 - 0.044 13.2 0.4 2.6 7.4 0.1 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI cobW PF02492.19 ADV20810.1 - 0.055 13.1 2.4 0.66 9.5 0.1 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NB-ARC PF00931.22 ADV20810.1 - 0.065 12.4 1.5 2 7.6 0.1 3.0 3 0 0 3 3 3 0 NB-ARC domain MeaB PF03308.16 ADV20810.1 - 0.07 12.1 0.9 1.6 7.6 0.2 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB TrwB_AAD_bind PF10412.9 ADV20810.1 - 0.086 11.7 0.9 7.2 5.4 0.1 2.4 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain Cytidylate_kin PF02224.18 ADV20810.1 - 0.09 12.5 0.2 3 7.5 0.0 3.1 3 1 1 4 4 4 0 Cytidylate kinase Dynamin_N PF00350.23 ADV20810.1 - 0.1 12.7 6.4 1.1 9.3 0.1 3.3 3 0 0 3 3 3 0 Dynamin family Viral_helicase1 PF01443.18 ADV20810.1 - 0.11 12.2 0.0 16 5.2 0.0 3.1 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase ATP_bind_1 PF03029.17 ADV20810.1 - 0.14 11.9 0.4 13 5.4 0.1 2.6 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_24 PF13479.6 ADV20810.1 - 0.19 11.4 3.1 5.9 6.6 0.1 2.8 3 0 0 3 3 2 0 AAA domain MobB PF03205.14 ADV20810.1 - 0.26 11.2 1.1 18 5.2 0.3 2.6 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_11 PF13086.6 ADV20810.1 - 0.64 9.7 4.5 1.5 8.5 0.0 3.4 4 0 0 4 4 4 0 AAA domain ABC_ATPase PF09818.9 ADV20810.1 - 1.7 7.4 6.2 0.81 8.4 0.1 2.8 3 0 0 3 3 3 0 Predicted ATPase of the ABC class NPCC PF08058.11 ADV20810.1 - 3.1 7.9 5.1 30 4.7 0.2 3.5 3 0 0 3 3 3 0 Nuclear pore complex component Endosulfine PF04667.17 ADV20811.1 - 4.5e-20 71.6 0.2 8.5e-20 70.7 0.2 1.4 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region zf-CCHC_3 PF13917.6 ADV20812.1 - 1.6e-17 63.1 2.1 3.4e-17 62.1 2.1 1.6 1 0 0 1 1 1 1 Zinc knuckle LAP1C PF05609.12 ADV20812.1 - 0.51 9.4 12.9 0.56 9.2 12.9 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) LRIF1 PF15741.5 ADV20812.1 - 0.6 8.6 15.7 0.71 8.3 15.7 1.1 1 0 0 1 1 1 0 Ligand-dependent nuclear receptor-interacting factor 1 TFIIF_alpha PF05793.12 ADV20812.1 - 2.4 6.6 25.1 2.9 6.4 25.1 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Macoilin PF09726.9 ADV20812.1 - 2.8 6.4 13.0 3 6.3 13.0 1.1 1 0 0 1 1 1 0 Macoilin family Sterol-sensing PF12349.8 ADV20813.1 - 3.6e-33 114.6 3.5 6.5e-33 113.7 3.5 1.4 1 0 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.18 ADV20813.1 - 1.6e-12 46.4 4.1 2.3e-12 45.9 4.1 1.1 1 0 0 1 1 1 1 Patched family Leo1 PF04004.13 ADV20815.1 - 6.9e-38 130.1 1.2 1.8e-37 128.7 0.0 2.1 2 0 0 2 2 2 1 Leo1-like protein Pmp3 PF01679.17 ADV20816.1 - 3.5e-25 87.9 8.4 4e-25 87.8 8.4 1.1 1 0 0 1 1 1 1 Proteolipid membrane potential modulator Phage_holin_Dp1 PF16938.5 ADV20816.1 - 0.21 11.8 2.4 1 9.6 0.2 2.0 1 1 0 2 2 2 0 Putative phage holin Dp-1 TM_helix PF05552.12 ADV20816.1 - 4.8 7.2 10.0 0.88 9.6 2.7 2.1 2 0 0 2 2 2 0 Conserved TM helix Ribosomal_L32p PF01783.23 ADV20817.1 - 7.1e-16 58.2 5.7 1e-15 57.7 5.7 1.2 1 0 0 1 1 1 1 Ribosomal L32p protein family DZR PF12773.7 ADV20817.1 - 0.033 14.2 0.6 0.061 13.4 0.6 1.4 1 0 0 1 1 1 0 Double zinc ribbon zinc-ribbons_6 PF07191.12 ADV20817.1 - 0.044 13.8 0.3 0.072 13.1 0.3 1.3 1 0 0 1 1 1 0 zinc-ribbons GFA PF04828.14 ADV20817.1 - 0.077 13.3 1.5 5.4 7.4 0.1 2.3 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme Zn-ribbon_8 PF09723.10 ADV20817.1 - 0.092 12.9 2.0 2.7 8.2 0.1 2.3 1 1 1 2 2 2 0 Zinc ribbon domain RecR PF02132.15 ADV20817.1 - 0.21 11.2 1.1 0.4 10.3 1.1 1.4 1 0 0 1 1 1 0 RecR protein PhnA_Zn_Ribbon PF08274.12 ADV20817.1 - 0.67 9.9 8.7 0.85 9.6 0.3 2.8 3 0 0 3 3 3 0 PhnA Zinc-Ribbon ICMT PF04140.14 ADV20818.1 - 3.7e-24 85.0 1.2 5.1e-24 84.5 0.3 1.7 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 ADV20818.1 - 7.3e-10 39.2 0.3 7.3e-10 39.2 0.3 2.2 2 1 0 2 2 2 1 Phospholipid methyltransferase DUF1295 PF06966.12 ADV20818.1 - 0.00017 21.2 0.3 0.00034 20.2 0.1 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1295) NnrU PF07298.11 ADV20818.1 - 0.003 17.1 0.4 0.003 17.1 0.4 1.9 2 0 0 2 2 2 1 NnrU protein DUF5353 PF17304.2 ADV20818.1 - 0.36 10.6 3.8 0.69 9.7 0.1 2.9 2 1 0 2 2 2 0 Family of unknown function (DUF5353) GDC-P PF02347.16 ADV20819.1 - 3.2e-173 576.5 0.1 2.8e-165 550.3 0.0 3.1 3 0 0 3 3 3 2 Glycine cleavage system P-protein Aminotran_5 PF00266.19 ADV20819.1 - 8.6e-07 28.2 0.0 0.0011 18.0 0.0 2.4 2 0 0 2 2 2 2 Aminotransferase class-V Beta_elim_lyase PF01212.21 ADV20819.1 - 0.085 12.1 0.0 0.17 11.1 0.0 1.4 1 0 0 1 1 1 0 Beta-eliminating lyase Ubiq_cyt_C_chap PF03981.12 ADV20820.1 - 5.9e-10 39.4 0.0 2e-09 37.6 0.0 1.9 1 1 0 1 1 1 1 Ubiquinol-cytochrome C chaperone NAP PF00956.18 ADV20821.1 - 2.3e-29 102.4 4.0 2.3e-29 102.4 4.0 2.4 2 1 0 2 2 2 1 Nucleosome assembly protein (NAP) Cwf_Cwc_15 PF04889.12 ADV20821.1 - 0.031 14.0 5.3 0.039 13.7 5.3 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CDC45 PF02724.14 ADV20821.1 - 0.51 8.6 4.8 0.64 8.3 4.8 1.2 1 0 0 1 1 1 0 CDC45-like protein YL1 PF05764.13 ADV20821.1 - 1.2 9.2 13.5 1.9 8.6 13.5 1.3 1 0 0 1 1 1 0 YL1 nuclear protein NOA36 PF06524.12 ADV20821.1 - 2.4 7.4 13.2 3.5 6.9 13.2 1.3 1 0 0 1 1 1 0 NOA36 protein CAF1C_H4-bd PF12265.8 ADV20822.1 - 1.4e-13 50.8 0.3 2.3e-12 47.0 0.0 2.4 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 ADV20822.1 - 3.2e-13 49.9 11.5 2.6e-05 24.9 0.0 5.3 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV20822.1 - 2.3e-05 24.6 0.1 0.031 14.6 0.0 3.4 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain PBP1_TM PF14812.6 ADV20822.1 - 0.95 9.9 11.7 1.9 8.9 5.3 2.3 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal MMR_HSR1 PF01926.23 ADV20824.1 - 4.6e-18 65.3 0.8 3.3e-15 56.1 0.0 2.8 3 0 0 3 3 3 2 50S ribosome-binding GTPase FeoB_N PF02421.18 ADV20824.1 - 3.6e-08 33.1 0.1 4.4e-06 26.3 0.0 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 ADV20824.1 - 2.9e-05 24.1 0.0 0.017 15.0 0.0 2.5 1 1 0 2 2 2 2 RsgA GTPase DUF1863 PF08937.11 ADV20824.1 - 0.001 19.4 0.0 0.0025 18.1 0.0 1.6 1 0 0 1 1 1 1 MTH538 TIR-like domain (DUF1863) Dynamin_N PF00350.23 ADV20824.1 - 0.0013 18.8 5.6 0.064 13.3 0.1 3.2 3 1 0 3 3 3 2 Dynamin family GTP_EFTU PF00009.27 ADV20824.1 - 0.0024 17.4 1.1 0.057 13.0 0.0 3.0 3 1 1 4 4 4 1 Elongation factor Tu GTP binding domain Roc PF08477.13 ADV20824.1 - 0.017 15.3 0.0 7.7 6.8 0.0 3.4 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.6 ADV20824.1 - 0.032 14.6 0.0 0.12 12.8 0.0 2.0 1 0 0 1 1 1 0 AAA ATPase domain RPN2_C PF18004.1 ADV20824.1 - 9 6.2 16.9 11 6.0 11.9 2.9 3 0 0 3 3 3 0 26S proteasome regulatory subunit RPN2 C-terminal domain Thioredoxin PF00085.20 ADV20825.1 - 2.5e-20 72.4 0.0 3e-20 72.1 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 ADV20825.1 - 6.4e-06 26.4 0.1 0.00079 19.7 0.0 2.2 1 1 1 2 2 2 1 Thioredoxin-like Thioredoxin_2 PF13098.6 ADV20825.1 - 7.7e-06 26.3 0.1 0.0001 22.7 0.1 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_3 PF13192.6 ADV20825.1 - 0.0011 19.0 0.0 0.0014 18.6 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin domain Thioredoxin_7 PF13899.6 ADV20825.1 - 0.002 18.3 0.2 0.0033 17.6 0.2 1.6 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_9 PF14595.6 ADV20825.1 - 0.013 15.2 0.0 0.017 14.9 0.0 1.1 1 0 0 1 1 1 0 Thioredoxin KaiB PF07689.12 ADV20825.1 - 0.014 15.1 0.0 0.02 14.6 0.0 1.3 1 0 0 1 1 1 0 KaiB domain TraF PF13728.6 ADV20825.1 - 0.081 12.7 0.0 0.1 12.4 0.0 1.1 1 0 0 1 1 1 0 F plasmid transfer operon protein Hydrolase_6 PF13344.6 ADV20826.1 - 1e-15 57.6 0.0 1.8e-15 56.9 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ADV20826.1 - 4.5e-15 55.5 0.0 7.6e-15 54.7 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 ADV20826.1 - 6.6e-05 23.3 0.0 0.028 14.7 0.1 2.7 2 2 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 ADV20826.1 - 0.052 13.6 0.0 0.12 12.4 0.0 1.6 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase IQ PF00612.27 ADV20828.1 - 9.3e-07 28.1 0.3 4.6e-06 25.9 0.3 2.3 1 0 0 1 1 1 1 IQ calmodulin-binding motif PBP_sp32 PF07222.12 ADV20828.1 - 0.084 12.3 4.7 0.17 11.3 4.7 1.6 1 0 0 1 1 1 0 Proacrosin binding protein sp32 ArAE_2_N PF10337.9 ADV20828.1 - 1.5 7.8 2.7 2.3 7.2 2.7 1.2 1 0 0 1 1 1 0 Putative ER transporter, 6TM, N-terminal Lipase_3 PF01764.25 ADV20829.1 - 1.1e-07 31.8 0.0 2.8e-07 30.5 0.0 1.7 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.7 ADV20829.1 - 5.5 7.5 8.6 0.59 10.7 1.0 2.8 2 2 0 2 2 2 0 Alpha/beta hydrolase family Coa1 PF08695.10 ADV20830.1 - 3.5e-33 113.8 0.0 4.7e-33 113.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 DUF4525 PF15027.6 ADV20830.1 - 0.044 13.5 0.1 0.073 12.8 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4525) Drc1-Sld2 PF11719.8 ADV20831.1 - 4e-13 49.7 8.3 4e-13 49.7 8.3 4.3 2 2 1 3 3 3 1 DNA replication and checkpoint protein Brix PF04427.18 ADV20832.1 - 2e-40 139.0 0.0 2.6e-40 138.6 0.0 1.1 1 0 0 1 1 1 1 Brix domain DUF4521 PF15021.6 ADV20832.1 - 0.0098 15.8 2.5 0.022 14.7 2.5 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF4521) HSA PF07529.13 ADV20833.1 - 4.2e-10 39.8 0.0 4.2e-10 39.8 0.0 3.2 4 0 0 4 4 4 1 HSA Myb_DNA-bind_6 PF13921.6 ADV20833.1 - 3e-07 30.6 0.2 6.7e-07 29.5 0.2 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 ADV20833.1 - 3.1e-07 30.5 0.0 7.7e-07 29.2 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain SANT_DAMP1_like PF16282.5 ADV20833.1 - 0.027 14.7 0.0 0.07 13.3 0.0 1.6 1 0 0 1 1 1 0 SANT/Myb-like domain of DAMP1 Mt_ATP-synt_B PF05405.14 ADV20834.1 - 1.3e-46 158.2 8.7 1.6e-46 157.9 8.7 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) SNAD3 PF18749.1 ADV20834.1 - 0.049 12.8 1.1 0.06 12.5 1.1 1.1 1 0 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 3 Yuri_gagarin PF15934.5 ADV20834.1 - 0.078 12.8 4.1 0.11 12.4 4.1 1.1 1 0 0 1 1 1 0 Yuri gagarin YtzH PF14165.6 ADV20834.1 - 0.11 12.9 1.5 0.28 11.6 0.9 1.9 1 1 1 2 2 2 0 YtzH-like protein RecR PF02132.15 ADV20835.1 - 0.0082 15.7 1.3 0.017 14.7 1.3 1.5 1 0 0 1 1 1 1 RecR protein zf-C3HC4_3 PF13920.6 ADV20835.1 - 0.025 14.4 1.0 0.049 13.5 1.0 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ADV20835.1 - 0.55 10.6 2.9 6.4 7.2 1.8 2.3 2 0 0 2 2 2 0 Ring finger domain zf-RING_5 PF14634.6 ADV20835.1 - 2 8.5 4.9 0.68 9.9 2.4 1.6 2 0 0 2 2 2 0 zinc-RING finger domain Snf7 PF03357.21 ADV20836.1 - 2.8e-39 134.5 14.7 2.8e-39 134.5 14.7 2.0 1 1 1 2 2 2 1 Snf7 Ribosomal_60s PF00428.19 ADV20836.1 - 0.083 13.5 3.8 0.54 10.9 0.1 2.7 2 1 1 3 3 3 0 60s Acidic ribosomal protein Atg14 PF10186.9 ADV20836.1 - 5.3 6.0 8.3 8.1 5.4 8.1 1.4 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 IML1 PF12257.8 ADV20837.1 - 6.4e-104 347.1 0.2 1.6e-103 345.8 0.0 1.7 2 0 0 2 2 2 1 Vacuolar membrane-associated protein Iml1 DEP PF00610.21 ADV20837.1 - 1.9e-15 56.7 0.2 3.7e-15 55.7 0.2 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) ELFV_dehydrog PF00208.21 ADV20838.1 - 7.9e-81 271.3 2.5 9.7e-81 271.1 2.5 1.1 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.18 ADV20838.1 - 3e-50 169.4 0.0 5.5e-50 168.6 0.0 1.4 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain NAD_binding_7 PF13241.6 ADV20838.1 - 0.0096 16.3 0.0 0.024 15.1 0.0 1.7 1 0 0 1 1 1 1 Putative NAD(P)-binding 2-Hacid_dh_C PF02826.19 ADV20838.1 - 0.14 11.5 0.0 0.26 10.6 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain CAF1A PF12253.8 ADV20839.1 - 1.7e-20 72.9 9.5 4.9e-20 71.5 9.5 1.9 1 0 0 1 1 1 1 Chromatin assembly factor 1 subunit A Cpn60_TCP1 PF00118.24 ADV20840.1 - 3.6e-149 497.6 12.5 4e-149 497.4 12.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Sua5_yciO_yrdC PF01300.18 ADV20840.1 - 0.00098 18.7 0.1 0.0059 16.1 0.0 2.2 2 0 0 2 2 2 1 Telomere recombination GCP_N_terminal PF17681.1 ADV20841.1 - 1.2e-97 327.2 0.0 3.7e-97 325.6 0.0 1.8 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 ADV20841.1 - 1.1e-84 284.6 2.4 2e-84 283.7 2.4 1.5 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal Hist_deacetyl PF00850.19 ADV20842.1 - 3.8e-87 292.6 0.0 5.2e-87 292.2 0.0 1.2 1 0 0 1 1 1 1 Histone deacetylase domain Arb2 PF09757.9 ADV20842.1 - 3.1e-41 141.2 0.1 4.3e-41 140.8 0.1 1.2 1 0 0 1 1 1 1 Arb2 domain DUF1749 PF08538.10 ADV20842.1 - 0.0021 17.2 0.0 0.0033 16.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1749) Chlorophyllase2 PF12740.7 ADV20842.1 - 0.091 11.7 0.0 0.2 10.6 0.0 1.5 1 0 0 1 1 1 0 Chlorophyllase enzyme Uds1 PF15456.6 ADV20844.1 - 1.7e-25 89.7 5.4 1.7e-25 89.7 5.4 7.0 4 2 0 4 4 4 1 Up-regulated During Septation MtrB PF05440.12 ADV20844.1 - 0.22 12.0 0.8 6.1 7.3 0.0 3.6 2 1 1 3 3 3 0 Tetrahydromethanopterin S-methyltransferase subunit B bVLRF1 PF18826.1 ADV20845.1 - 3.6e-61 205.4 0.1 1.1e-60 203.9 0.0 1.8 2 0 0 2 2 2 1 bacteroidetes VLRF1 release factor zf-C2H2_jaz PF12171.8 ADV20845.1 - 0.18 12.1 0.1 0.37 11.1 0.1 1.6 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding AAA_23 PF13476.6 ADV20845.1 - 0.41 11.1 7.9 0.29 11.6 4.0 2.3 2 0 0 2 2 2 0 AAA domain PX PF00787.24 ADV20846.1 - 1.5e-21 76.5 1.9 2.2e-21 75.9 0.5 2.0 2 0 0 2 2 2 1 PX domain Vps5 PF09325.10 ADV20846.1 - 1.3e-10 41.3 0.5 2e-06 27.5 0.9 2.3 2 1 0 2 2 2 2 Vps5 C terminal like Glycos_trans_3N PF02885.17 ADV20846.1 - 0.12 12.2 0.2 9.7 6.1 0.0 2.5 2 0 0 2 2 2 0 Glycosyl transferase family, helical bundle domain FAA_hydro_N_2 PF18288.1 ADV20846.1 - 0.16 12.5 0.1 0.44 11.0 0.1 1.8 1 0 0 1 1 1 0 Fumarylacetoacetase N-terminal domain 2 Surfac_D-trimer PF09006.11 ADV20846.1 - 0.17 11.8 0.3 1.5 8.8 0.0 2.7 4 0 0 4 4 4 0 Lung surfactant protein D coiled-coil trimerisation ING PF12998.7 ADV20846.1 - 0.27 11.9 3.3 19 5.9 1.8 2.6 2 0 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding GATA PF00320.27 ADV20847.1 - 1.1e-12 47.3 3.8 1.9e-12 46.5 3.8 1.4 1 0 0 1 1 1 1 GATA zinc finger FAM76 PF16046.5 ADV20847.1 - 0.049 13.0 0.5 0.095 12.0 0.5 1.4 1 0 0 1 1 1 0 FAM76 protein ArfGap PF01412.18 ADV20847.1 - 0.11 12.6 0.0 0.21 11.7 0.0 1.4 1 0 0 1 1 1 0 Putative GTPase activating protein for Arf Nudix_N_2 PF14803.6 ADV20847.1 - 0.15 12.0 1.6 0.31 11.0 1.6 1.5 1 0 0 1 1 1 0 Nudix N-terminal DEAD PF00270.29 ADV20848.1 - 1.3e-42 145.5 0.2 2.2e-42 144.8 0.2 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ADV20848.1 - 9e-31 106.5 0.0 3.8e-30 104.5 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_19 PF13245.6 ADV20848.1 - 0.00046 20.5 0.1 0.019 15.3 0.0 2.3 2 0 0 2 2 2 1 AAA domain ResIII PF04851.15 ADV20848.1 - 0.0014 18.7 0.0 0.0028 17.7 0.0 1.5 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 ADV20848.1 - 0.017 14.8 0.0 0.029 14.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain PrmC_N PF17827.1 ADV20849.1 - 7.9e-08 32.8 0.1 1.8e-07 31.7 0.1 1.6 1 0 0 1 1 1 1 PrmC N-terminal domain MTS PF05175.14 ADV20849.1 - 1.9e-07 30.8 0.0 3.1e-07 30.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.6 ADV20849.1 - 3.9e-07 30.0 0.0 5.5e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ADV20849.1 - 5.7e-05 23.7 0.0 0.0001 22.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 ADV20849.1 - 0.0024 17.3 0.0 0.0035 16.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) UPF0020 PF01170.18 ADV20849.1 - 0.0029 17.3 0.0 0.0051 16.5 0.0 1.3 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 N6_Mtase PF02384.16 ADV20849.1 - 0.013 14.8 0.0 0.018 14.3 0.0 1.2 1 0 0 1 1 1 0 N-6 DNA Methylase Methyltransf_18 PF12847.7 ADV20849.1 - 0.015 15.3 0.0 0.026 14.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain AviRa PF11599.8 ADV20849.1 - 0.062 12.7 0.0 0.15 11.5 0.0 1.5 1 1 1 2 2 2 0 RRNA methyltransferase AviRa Cons_hypoth95 PF03602.15 ADV20849.1 - 0.07 12.8 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 tRNA-synt_His PF13393.6 ADV20850.1 - 5.3e-35 121.2 0.0 4e-30 105.2 0.0 2.3 2 0 0 2 2 2 2 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 ADV20850.1 - 8e-08 32.3 0.1 2.7e-07 30.6 0.0 2.0 2 0 0 2 2 2 1 Anticodon binding domain Seryl_tRNA_N PF02403.22 ADV20850.1 - 0.0023 18.1 1.6 0.0052 17.0 1.6 1.5 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain ZapB PF06005.12 ADV20850.1 - 0.024 15.1 1.6 0.034 14.6 0.6 1.7 2 0 0 2 2 2 0 Cell division protein ZapB WHEP-TRS PF00458.20 ADV20850.1 - 0.038 14.2 3.3 0.13 12.4 3.3 2.1 1 0 0 1 1 1 0 WHEP-TRS domain CC2-LZ PF16516.5 ADV20850.1 - 0.079 13.3 1.9 0.19 12.1 1.9 1.6 1 0 0 1 1 1 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator DivIC PF04977.15 ADV20850.1 - 0.19 11.5 1.4 0.38 10.6 1.4 1.5 1 0 0 1 1 1 0 Septum formation initiator FlxA PF14282.6 ADV20850.1 - 0.46 10.5 5.5 0.97 9.5 5.5 1.5 1 0 0 1 1 1 0 FlxA-like protein TauD PF02668.16 ADV20851.1 - 4.8e-57 193.8 0.0 6.1e-57 193.5 0.0 1.0 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Sigma70_r1_1 PF03979.14 ADV20851.1 - 0.053 13.6 0.1 0.097 12.7 0.1 1.4 1 0 0 1 1 1 0 Sigma-70 factor, region 1.1 GFO_IDH_MocA PF01408.22 ADV20852.1 - 2.5e-12 47.7 0.0 5.6e-12 46.5 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_5 PF07994.12 ADV20853.1 - 1.3e-144 481.5 0.0 2.6e-144 480.6 0.0 1.4 2 0 0 2 2 2 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.17 ADV20853.1 - 2.5e-43 146.8 0.2 2.5e-43 146.8 0.2 1.8 2 0 0 2 2 2 1 Myo-inositol-1-phosphate synthase DASH_Hsk3 PF08227.11 ADV20854.1 - 0.34 11.3 2.9 9.5 6.7 1.5 3.7 2 0 0 2 2 2 0 DASH complex subunit Hsk3 like ApoO PF09769.9 ADV20854.1 - 2.4 8.1 4.9 10 6.1 0.4 3.2 2 0 0 2 2 2 0 Apolipoprotein O GAS PF13851.6 ADV20854.1 - 8.9 5.6 105.8 0.036 13.4 17.0 5.4 2 2 2 5 5 5 0 Growth-arrest specific micro-tubule binding Myosin_head PF00063.21 ADV20855.1 - 2.3e-255 849.1 0.0 7.2e-255 847.4 0.0 1.9 2 0 0 2 2 2 1 Myosin head (motor domain) Myosin_N PF02736.19 ADV20855.1 - 5.6e-06 26.1 0.0 1.2e-05 25.0 0.0 1.6 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain Myosin_tail_1 PF01576.19 ADV20855.1 - 0.0053 14.6 129.4 0.0078 14.1 129.4 1.2 1 0 0 1 1 1 1 Myosin tail IQ PF00612.27 ADV20855.1 - 0.021 14.6 4.3 0.77 9.7 1.4 2.8 2 0 0 2 2 2 0 IQ calmodulin-binding motif AAA_22 PF13401.6 ADV20855.1 - 0.038 14.3 0.0 0.038 14.3 0.0 4.7 4 1 0 4 4 4 0 AAA domain TsaE PF02367.17 ADV20855.1 - 0.084 12.9 0.0 0.26 11.3 0.0 1.8 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Baculo_PEP_C PF04513.12 ADV20855.1 - 0.66 10.0 21.5 0.28 11.2 0.7 4.6 3 2 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus AA_permease_2 PF13520.6 ADV20856.1 - 7.7e-57 193.0 46.5 9.5e-57 192.7 46.5 1.0 1 0 0 1 1 1 1 Amino acid permease RGS PF00615.19 ADV20857.1 - 1.7e-05 25.0 0.0 0.00023 21.4 0.0 2.2 2 0 0 2 2 2 1 Regulator of G protein signaling domain Pkinase PF00069.25 ADV20858.1 - 1.9e-38 132.4 0.0 3.1e-38 131.6 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV20858.1 - 1.3e-13 50.9 0.1 3.7e-13 49.4 0.0 1.8 2 1 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 ADV20858.1 - 8.9e-06 25.2 0.0 1.5e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 ADV20858.1 - 0.047 13.0 0.1 0.09 12.1 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ADV20858.1 - 0.074 13.0 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family UCH PF00443.29 ADV20859.1 - 3.7e-29 102.0 0.0 2.6e-28 99.2 0.0 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 ADV20859.1 - 3.1e-10 40.2 0.0 5.9e-10 39.3 0.0 1.4 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.6 ADV20859.1 - 0.0024 17.5 0.2 0.028 14.0 0.2 2.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase VIR_N PF15912.5 ADV20859.1 - 0.18 11.4 3.5 0.29 10.7 3.5 1.3 1 0 0 1 1 1 0 Virilizer, N-terminal Aldo_ket_red PF00248.21 ADV20860.1 - 1.2e-42 146.2 0.0 3.7e-41 141.2 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family MFS_1 PF07690.16 ADV20861.1 - 5.1e-33 114.5 40.1 5.1e-33 114.5 40.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Peptidase_A25 PF03418.14 ADV20861.1 - 0.14 11.1 0.0 0.21 10.5 0.0 1.1 1 0 0 1 1 1 0 Germination protease COX4_pro PF03626.14 ADV20863.1 - 2.6 8.5 10.1 0.27 11.7 4.7 2.2 2 1 0 2 2 2 0 Prokaryotic Cytochrome C oxidase subunit IV DUF2070 PF09843.9 ADV20863.1 - 7.1 4.8 8.8 8.1 4.6 8.8 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) TruB_N PF01509.18 ADV20864.1 - 3.1e-38 131.5 0.0 5e-37 127.5 0.0 2.2 2 0 0 2 2 2 1 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 ADV20864.1 - 7.2e-10 38.9 0.0 1.7e-09 37.7 0.0 1.6 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain Methyltransf_16 PF10294.9 ADV20865.1 - 4.1e-30 104.8 0.0 1.4e-28 99.8 0.0 2.1 1 1 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 ADV20865.1 - 1.6e-05 24.8 0.0 2.4e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 ADV20865.1 - 0.0012 18.4 0.1 0.0018 17.8 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) RrnaAD PF00398.20 ADV20865.1 - 0.0028 16.7 0.4 0.0091 15.1 0.4 1.7 1 1 0 1 1 1 1 Ribosomal RNA adenine dimethylase MTS PF05175.14 ADV20865.1 - 0.081 12.5 0.0 0.18 11.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain Met_10 PF02475.16 ADV20865.1 - 0.084 12.6 0.0 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 Met-10+ like-protein Amino_oxidase PF01593.24 ADV20866.1 - 7.9e-62 210.0 0.4 2.3e-61 208.5 0.4 1.6 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 ADV20866.1 - 3.6e-15 55.9 0.6 7.9e-15 54.8 0.6 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 ADV20866.1 - 4.5e-05 22.7 1.6 6.9e-05 22.1 1.6 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 ADV20866.1 - 7.4e-05 23.2 0.3 0.024 15.2 0.1 2.8 3 0 0 3 3 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 ADV20866.1 - 0.00012 21.4 0.3 0.0011 18.2 0.4 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 ADV20866.1 - 0.00027 19.8 1.1 0.001 17.9 0.3 2.0 2 0 0 2 2 2 1 HI0933-like protein DAO PF01266.24 ADV20866.1 - 0.00099 18.8 3.5 0.0048 16.5 3.5 1.8 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 ADV20866.1 - 0.003 16.9 1.3 0.81 8.9 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 ADV20866.1 - 0.0032 16.7 0.5 0.0051 16.1 0.5 1.2 1 0 0 1 1 1 1 Thi4 family FAD_oxidored PF12831.7 ADV20866.1 - 0.0058 16.0 0.6 0.0083 15.5 0.6 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 ADV20866.1 - 0.0087 15.3 0.0 0.013 14.8 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain GIDA PF01134.22 ADV20866.1 - 0.043 12.9 0.8 0.07 12.2 0.8 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A Lycopene_cycl PF05834.12 ADV20866.1 - 0.098 11.7 1.0 0.3 10.1 0.8 1.8 2 0 0 2 2 2 0 Lycopene cyclase protein GLF PF03275.13 ADV20866.1 - 0.1 12.3 0.0 0.16 11.7 0.0 1.2 1 0 0 1 1 1 0 UDP-galactopyranose mutase GDI PF00996.18 ADV20866.1 - 0.21 10.1 0.0 0.33 9.4 0.0 1.2 1 0 0 1 1 1 0 GDP dissociation inhibitor Trm112p PF03966.16 ADV20867.1 - 7.4e-21 74.5 0.0 1e-20 74.1 0.0 1.2 1 0 0 1 1 1 1 Trm112p-like protein Pox_MCEL PF03291.16 ADV20868.1 - 2.3e-81 273.5 0.0 3.3e-81 273.0 0.0 1.2 1 0 0 1 1 1 1 mRNA capping enzyme Methyltransf_25 PF13649.6 ADV20868.1 - 1.5e-09 38.4 0.0 3.2e-09 37.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ADV20868.1 - 2.2e-07 30.8 0.0 3.5e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ADV20868.1 - 4e-07 30.7 0.0 7.3e-07 29.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ADV20868.1 - 1.1e-05 26.0 0.0 2.3e-05 24.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ADV20868.1 - 0.0023 17.8 0.0 0.004 17.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 ADV20868.1 - 0.025 13.8 0.0 0.042 13.0 0.0 1.2 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family MetW PF07021.12 ADV20868.1 - 0.04 13.5 0.0 0.15 11.7 0.0 1.8 2 0 0 2 2 2 0 Methionine biosynthesis protein MetW MGTL PF17059.5 ADV20868.1 - 0.56 10.1 6.5 0.43 10.4 1.9 2.9 2 0 0 2 2 2 0 MgtA leader peptide ANAPC5 PF12862.7 ADV20869.1 - 1.4e-14 53.9 0.6 2.8e-14 53.0 0.6 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 5 Synuclein PF01387.17 ADV20870.1 - 0.035 14.3 0.4 0.065 13.5 0.4 1.4 1 0 0 1 1 1 0 Synuclein MMR_HSR1 PF01926.23 ADV20871.1 - 2.1e-15 56.8 0.0 3.3e-14 53.0 0.0 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ADV20871.1 - 9.1e-06 25.3 0.0 4.1e-05 23.2 0.1 2.0 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 ADV20871.1 - 3.1e-05 23.9 0.0 0.028 14.3 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AIG1 PF04548.16 ADV20871.1 - 0.00088 18.7 0.1 0.0023 17.3 0.1 1.7 1 0 0 1 1 1 1 AIG1 family cobW PF02492.19 ADV20871.1 - 0.13 11.9 0.1 0.76 9.3 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain DUF1479 PF07350.12 ADV20872.1 - 5.5e-160 532.7 0.0 6.4e-160 532.5 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1479) COPIIcoated_ERV PF07970.12 ADV20873.1 - 1.8e-83 279.7 0.1 2.6e-83 279.3 0.1 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 ADV20873.1 - 2e-25 89.0 0.7 4.3e-25 87.9 0.1 1.8 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) DUF1433 PF07252.11 ADV20873.1 - 0.14 12.4 0.3 0.62 10.3 0.0 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1433) GTP_EFTU PF00009.27 ADV20874.1 - 3.2e-58 196.5 0.0 6.7e-58 195.4 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 ADV20874.1 - 3.2e-40 136.7 0.3 1.3e-39 134.7 0.0 2.2 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_II PF14492.6 ADV20874.1 - 6.3e-30 103.1 0.0 1.7e-29 101.7 0.0 1.8 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 ADV20874.1 - 2.4e-24 85.2 0.3 6.8e-24 83.7 0.1 1.9 2 0 0 2 2 2 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 ADV20874.1 - 5.5e-15 55.5 0.3 1.6e-14 54.0 0.1 2.0 2 0 0 2 2 2 1 Elongation factor Tu domain 2 RF3_C PF16658.5 ADV20874.1 - 4.6e-06 26.5 0.0 9.8e-06 25.4 0.0 1.6 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain BAT PF15915.5 ADV20874.1 - 0.54 10.1 3.1 20 5.0 0.1 2.8 3 0 0 3 3 3 0 GAF and HTH_10 associated domain DNA_pol_phi PF04931.13 ADV20875.1 - 5.4e-224 745.7 13.2 5.4e-224 745.7 13.2 2.3 2 0 0 2 2 2 1 DNA polymerase phi DUF937 PF06078.11 ADV20875.1 - 0.0091 16.6 4.5 0.033 14.8 2.7 2.9 3 0 0 3 3 3 1 Bacterial protein of unknown function (DUF937) SDA1 PF05285.12 ADV20875.1 - 4 6.8 41.7 0.43 10.0 22.1 2.3 2 0 0 2 2 2 0 SDA1 Myc_N PF01056.18 ADV20875.1 - 8.2 6.2 17.6 2.1 8.2 6.0 2.7 2 0 0 2 2 2 0 Myc amino-terminal region Sec66 PF09802.9 ADV20876.1 - 2e-54 183.9 0.2 2.3e-54 183.7 0.2 1.0 1 0 0 1 1 1 1 Preprotein translocase subunit Sec66 Ribosomal_L5_C PF00673.21 ADV20877.1 - 8.7e-24 83.5 0.0 1.4e-23 82.9 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 ADV20877.1 - 1.5e-08 34.9 1.7 8.7e-07 29.2 1.7 2.6 1 1 0 1 1 1 1 Ribosomal protein L5 Lyase_1 PF00206.20 ADV20878.1 - 8.5e-119 396.6 0.1 1.2e-118 396.0 0.1 1.2 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.9 ADV20878.1 - 3.4e-18 65.8 0.1 9e-18 64.4 0.1 1.8 1 0 0 1 1 1 1 Fumarase C C-terminus HECT_2 PF09814.9 ADV20879.1 - 5.8e-41 140.6 0.0 9.9e-41 139.8 0.0 1.3 1 0 0 1 1 1 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding Takusan PF04822.13 ADV20879.1 - 0.062 13.2 6.7 0.062 13.2 3.1 2.6 2 0 0 2 2 2 0 Takusan IF-2B PF01008.17 ADV20880.1 - 7.6e-56 189.4 0.0 2.3e-55 187.8 0.0 1.6 1 1 0 1 1 1 1 Initiation factor 2 subunit family Pkinase PF00069.25 ADV20882.1 - 4.1e-73 246.0 0.0 4.7e-73 245.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV20882.1 - 9.6e-31 107.0 0.0 1.3e-30 106.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ADV20882.1 - 0.00034 20.0 0.1 0.05 12.9 0.0 2.3 1 1 0 2 2 2 2 Kinase-like Haspin_kinase PF12330.8 ADV20882.1 - 0.0015 17.5 0.0 0.0029 16.6 0.0 1.4 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 ADV20882.1 - 0.025 14.5 0.0 0.083 12.8 0.0 1.7 2 0 0 2 2 2 0 Phosphotransferase enzyme family LSM PF01423.22 ADV20883.1 - 1.9e-13 49.9 0.2 2.8e-13 49.3 0.2 1.2 1 0 0 1 1 1 1 LSM domain UbiA PF01040.18 ADV20884.1 - 2.5e-51 174.4 18.9 3.1e-51 174.1 18.9 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family Ras PF00071.22 ADV20886.1 - 5.3e-49 165.9 0.1 6.5e-49 165.6 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ADV20886.1 - 7.1e-19 68.2 0.0 1.1e-18 67.6 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ADV20886.1 - 1.1e-09 38.0 0.0 1.7e-09 37.4 0.0 1.3 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ADV20886.1 - 0.0002 21.0 0.0 0.00041 20.0 0.0 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1_Xtn PF16897.5 ADV20886.1 - 0.00078 19.4 0.0 0.0016 18.4 0.0 1.6 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain MMR_HSR1 PF01926.23 ADV20886.1 - 0.01 15.9 0.0 0.026 14.6 0.0 1.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase Septin PF00735.18 ADV20886.1 - 0.098 11.9 0.0 0.16 11.2 0.0 1.4 1 0 0 1 1 1 0 Septin F_bP_aldolase PF01116.20 ADV20887.1 - 4e-72 243.0 0.0 4.6e-72 242.8 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II YIF1 PF03878.15 ADV20888.1 - 1.7e-91 306.0 0.3 2.1e-91 305.7 0.3 1.1 1 0 0 1 1 1 1 YIF1 Yip1 PF04893.17 ADV20888.1 - 0.071 12.8 10.7 0.18 11.5 10.7 1.7 1 1 0 1 1 1 0 Yip1 domain Ribosomal_S15 PF00312.22 ADV20889.1 - 8e-22 77.3 1.4 2.3e-21 75.8 0.1 2.0 2 0 0 2 2 2 1 Ribosomal protein S15 Transp_cyt_pur PF02133.15 ADV20890.1 - 1.1e-35 123.2 37.1 1.5e-35 122.8 37.1 1.1 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin TM_helix PF05552.12 ADV20890.1 - 0.43 10.6 3.2 9 6.4 0.3 3.4 2 0 0 2 2 2 0 Conserved TM helix TPR_1 PF00515.28 ADV20892.1 - 3.9e-43 143.6 6.1 7.7e-07 28.7 0.0 11.3 11 0 0 11 11 11 8 Tetratricopeptide repeat TPR_2 PF07719.17 ADV20892.1 - 4.5e-41 135.7 2.0 7.9e-05 22.5 0.0 11.0 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_8 PF13181.6 ADV20892.1 - 3e-26 89.4 9.3 0.0028 17.7 0.0 10.5 11 0 0 11 11 10 6 Tetratricopeptide repeat TPR_11 PF13414.6 ADV20892.1 - 1.2e-24 85.7 3.5 0.00026 20.6 0.1 9.2 8 1 1 9 9 9 6 TPR repeat TPR_12 PF13424.6 ADV20892.1 - 5.5e-21 74.6 7.7 0.0031 17.8 0.0 8.1 5 4 4 9 9 9 7 Tetratricopeptide repeat TPR_17 PF13431.6 ADV20892.1 - 1.6e-20 72.0 0.4 0.025 14.9 0.0 9.7 10 0 0 10 10 10 3 Tetratricopeptide repeat TPR_16 PF13432.6 ADV20892.1 - 4.4e-18 65.6 2.1 2.2e-05 25.0 0.0 6.4 5 3 2 7 7 7 4 Tetratricopeptide repeat TPR_14 PF13428.6 ADV20892.1 - 6.6e-18 63.9 6.2 0.0007 20.2 0.0 9.7 5 4 5 10 10 10 3 Tetratricopeptide repeat TPR_19 PF14559.6 ADV20892.1 - 2.1e-16 60.2 7.2 1.7e-05 25.2 0.6 6.0 5 1 1 6 6 6 4 Tetratricopeptide repeat TPR_9 PF13371.6 ADV20892.1 - 1.9e-13 50.3 0.1 0.003 17.7 0.0 6.1 4 2 3 7 7 7 3 Tetratricopeptide repeat TPR_7 PF13176.6 ADV20892.1 - 7.9e-12 44.3 3.9 0.23 11.6 0.1 7.5 6 1 1 7 7 7 2 Tetratricopeptide repeat TPR_10 PF13374.6 ADV20892.1 - 7.8e-08 32.0 10.2 0.44 10.5 0.0 8.2 8 1 1 9 9 8 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ADV20892.1 - 1.1e-06 28.8 5.9 0.054 13.7 0.0 4.8 3 2 3 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 ADV20892.1 - 2.5e-06 27.7 3.4 0.3 11.8 0.0 7.6 8 1 0 8 8 7 1 Tetratricopeptide repeat TPR_MalT PF17874.1 ADV20892.1 - 0.00018 21.0 0.4 0.0016 17.9 0.3 2.6 3 1 1 4 4 4 1 MalT-like TPR region TPR_21 PF09976.9 ADV20892.1 - 0.00027 20.7 4.0 1.7 8.3 0.2 5.4 5 2 0 5 5 5 1 Tetratricopeptide repeat-like domain Sel1 PF08238.12 ADV20892.1 - 0.0026 18.4 2.6 2.9 8.7 0.1 4.2 4 0 0 4 4 3 1 Sel1 repeat DUF3856 PF12968.7 ADV20892.1 - 0.0035 17.4 1.6 12 5.9 0.0 4.9 3 2 0 5 5 5 0 Domain of Unknown Function (DUF3856) ANAPC5 PF12862.7 ADV20892.1 - 0.045 13.8 5.4 7.2 6.7 0.2 4.6 4 1 0 4 4 4 0 Anaphase-promoting complex subunit 5 SHNi-TPR PF10516.9 ADV20892.1 - 0.6 9.6 5.9 8 6.0 0.1 4.5 4 0 0 4 4 4 0 SHNi-TPR TPR_20 PF14561.6 ADV20892.1 - 1.7 9.0 6.1 17 5.8 0.0 3.8 4 1 0 4 4 4 0 Tetratricopeptide repeat MIT PF04212.18 ADV20892.1 - 1.7 8.7 9.5 3.9 7.6 0.1 4.3 5 0 0 5 5 4 0 MIT (microtubule interacting and transport) domain CPSase_L_D2 PF02786.17 ADV20893.1 - 1.4e-72 243.6 0.0 2.4e-72 242.9 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 ADV20893.1 - 3.6e-44 149.8 0.2 1e-43 148.3 0.0 1.9 2 0 0 2 2 2 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 ADV20893.1 - 4.2e-35 120.1 0.0 8.8e-35 119.1 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 ADV20893.1 - 2.2e-18 65.8 2.6 4.7e-18 64.8 2.6 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 ADV20893.1 - 4.6e-08 32.8 0.0 1.2e-07 31.5 0.0 1.5 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 ADV20893.1 - 1.6e-07 31.1 0.0 5.5e-07 29.3 0.0 1.8 2 0 0 2 2 2 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.6 ADV20893.1 - 1.9e-05 24.4 0.2 0.0064 16.3 0.0 2.5 1 1 1 2 2 2 2 Biotin-lipoyl like ATP-grasp_3 PF02655.14 ADV20893.1 - 0.0006 19.9 0.0 0.0017 18.5 0.0 1.8 1 1 0 1 1 1 1 ATP-grasp domain Ntox43 PF15537.6 ADV20893.1 - 0.024 14.7 0.0 0.055 13.5 0.0 1.5 1 0 0 1 1 1 0 Bacterial toxin 43 HlyD_D23 PF16576.5 ADV20893.1 - 0.079 12.2 0.3 6.7 5.9 0.0 2.3 1 1 1 2 2 2 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion Na_H_Exchanger PF00999.21 ADV20894.1 - 3.3e-61 207.2 23.8 3.9e-61 206.9 23.8 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family YrhC PF14143.6 ADV20894.1 - 0.29 11.2 1.1 1.1 9.5 0.2 2.4 2 0 0 2 2 2 0 YrhC-like protein Gcd10p PF04189.13 ADV20895.1 - 1.7e-77 260.5 0.0 3.6e-77 259.4 0.0 1.5 2 0 0 2 2 2 1 Gcd10p family MFS_1 PF07690.16 ADV20896.1 - 4.8e-31 108.0 40.1 4.8e-31 108.0 40.1 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF2970 PF11174.8 ADV20896.1 - 0.35 10.8 3.2 1 9.2 0.5 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2970) Fungal_trans PF04082.18 ADV20897.1 - 7.5e-05 21.9 0.0 0.00013 21.1 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Carboxyl_trans PF01039.22 ADV20898.1 - 5.6e-140 467.2 0.2 6.9e-140 466.9 0.2 1.0 1 0 0 1 1 1 1 Carboxyl transferase domain MdcE PF06833.11 ADV20898.1 - 0.0066 16.0 0.4 0.76 9.2 0.1 2.3 2 0 0 2 2 2 2 Malonate decarboxylase gamma subunit (MdcE) ECH_1 PF00378.20 ADV20898.1 - 0.083 12.2 0.1 0.15 11.4 0.1 1.3 1 0 0 1 1 1 0 Enoyl-CoA hydratase/isomerase Lactamase_B_2 PF12706.7 ADV20899.1 - 4.6e-22 78.5 0.1 6.4e-19 68.3 0.0 2.2 2 0 0 2 2 2 2 Beta-lactamase superfamily domain Lactamase_B PF00753.27 ADV20899.1 - 1.7e-07 31.5 1.8 2.3e-07 31.0 0.1 2.0 2 1 0 2 2 2 1 Metallo-beta-lactamase superfamily Lactamase_B_3 PF13483.6 ADV20899.1 - 0.016 15.1 0.0 0.038 13.9 0.0 1.6 2 0 0 2 2 2 0 Beta-lactamase superfamily domain Lactamase_B_6 PF16661.5 ADV20899.1 - 0.12 11.8 0.0 0.22 11.0 0.0 1.3 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily domain Peptidase_M50B PF13398.6 ADV20900.1 - 4.8e-41 140.6 16.4 5.9e-41 140.3 16.4 1.1 1 0 0 1 1 1 1 Peptidase M50B-like Neurensin PF14927.6 ADV20900.1 - 3 7.6 5.5 4.7 6.9 3.8 2.1 1 1 0 1 1 1 0 Neurensin CDP-OH_P_transf PF01066.21 ADV20900.1 - 8.7 7.2 10.9 2.7 8.8 6.6 2.4 1 1 1 2 2 2 0 CDP-alcohol phosphatidyltransferase tRNA_int_endo PF01974.17 ADV20901.1 - 4.1e-08 33.2 0.0 7.3e-08 32.4 0.0 1.3 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain DUF5546 PF17700.1 ADV20901.1 - 1.5 9.2 5.5 0.61 10.4 1.2 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5546) Dynactin_p62 PF05502.13 ADV20902.1 - 3.9e-64 217.2 2.3 6.3e-43 147.3 2.6 2.2 2 0 0 2 2 2 2 Dynactin p62 family IHABP4_N PF16174.5 ADV20902.1 - 0.62 10.6 8.0 0.65 10.6 6.7 1.7 2 0 0 2 2 2 0 Intracellular hyaluronan-binding protein 4 N-terminal TPR_12 PF13424.6 ADV20903.1 - 1.3e-09 38.2 8.6 0.0087 16.3 0.2 5.2 5 1 0 5 5 5 3 Tetratricopeptide repeat TPR_10 PF13374.6 ADV20903.1 - 1.6e-07 31.0 6.3 0.35 10.8 0.1 5.4 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 ADV20903.1 - 6e-07 29.1 11.0 0.048 13.8 0.2 5.3 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_8 PF13181.6 ADV20903.1 - 7.9e-07 28.8 5.0 1.3 9.4 0.1 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 ADV20903.1 - 2.5e-06 27.1 1.4 3.6 7.8 0.1 5.4 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 ADV20903.1 - 0.0019 18.0 12.2 0.54 10.2 0.2 4.4 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 ADV20903.1 - 0.31 12.0 10.1 52 5.0 0.2 5.8 5 1 2 7 7 7 0 Tetratricopeptide repeat TPR_19 PF14559.6 ADV20903.1 - 0.35 11.4 4.6 7.9 7.1 0.1 4.4 4 1 1 5 5 5 0 Tetratricopeptide repeat Acetyltransf_13 PF13880.6 ADV20904.1 - 7.3e-17 61.1 0.0 1.2e-16 60.5 0.0 1.3 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase zf-C2H2_3 PF13878.6 ADV20904.1 - 0.00032 20.4 0.7 0.0006 19.6 0.7 1.5 1 0 0 1 1 1 1 zinc-finger of acetyl-transferase ESCO Acetyltransf_7 PF13508.7 ADV20904.1 - 0.057 13.8 0.0 0.12 12.8 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Dynamin_M PF01031.20 ADV20905.1 - 2.6e-109 364.9 0.0 4.9e-109 364.0 0.0 1.5 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.23 ADV20905.1 - 1.2e-53 181.6 0.0 2.4e-53 180.6 0.0 1.5 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 ADV20905.1 - 5.6e-29 100.1 0.9 5.4e-28 97.0 0.4 2.3 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 ADV20905.1 - 0.00055 20.0 0.1 0.0076 16.3 0.1 2.7 2 1 0 2 2 2 1 50S ribosome-binding GTPase AIG1 PF04548.16 ADV20905.1 - 0.1 11.9 0.1 3.6 6.9 0.1 2.3 2 0 0 2 2 2 0 AIG1 family Lipase_GDSL_2 PF13472.6 ADV20906.1 - 0.093 13.1 0.0 0.23 11.8 0.0 1.7 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family Bact_lectin PF18483.1 ADV20908.1 - 1.7e-15 57.6 0.0 2.3e-15 57.1 0.0 1.2 1 0 0 1 1 1 1 Bacterial lectin Transglut_core PF01841.19 ADV20908.1 - 1.3e-12 48.2 1.4 2.7e-12 47.1 1.4 1.5 1 0 0 1 1 1 1 Transglutaminase-like superfamily Lectin_legB PF00139.19 ADV20908.1 - 1.3e-09 38.0 0.0 2.1e-09 37.3 0.0 1.2 1 0 0 1 1 1 1 Legume lectin domain Rad4 PF03835.15 ADV20908.1 - 3.1e-06 26.9 0.0 6.7e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain Lectin_leg-like PF03388.13 ADV20908.1 - 0.0036 16.7 0.0 0.0086 15.4 0.0 1.5 2 0 0 2 2 2 1 Legume-like lectin family CHASE3 PF05227.13 ADV20908.1 - 0.098 12.6 1.6 2 8.3 0.1 2.3 2 0 0 2 2 2 0 CHASE3 domain Glyco_hydro_31 PF01055.26 ADV20909.1 - 2.7e-73 247.7 0.0 3.6e-73 247.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 ADV20909.1 - 2.4e-08 34.2 0.2 1.5e-07 31.7 0.1 2.4 2 0 0 2 2 2 1 Galactose mutarotase-like TRAPPC-Trs85 PF12739.7 ADV20910.1 - 7.3e-102 341.4 0.0 9.3e-102 341.0 0.0 1.1 1 0 0 1 1 1 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit TRAPPC9-Trs120 PF08626.11 ADV20910.1 - 0.012 13.0 0.0 0.018 12.4 0.0 1.1 1 0 0 1 1 1 0 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit CENP-T_C PF15511.6 ADV20911.1 - 4.7e-08 33.1 0.0 5.8e-08 32.8 0.0 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAF PF02969.17 ADV20911.1 - 8.4e-05 22.7 0.1 0.00012 22.2 0.1 1.3 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-S PF15630.6 ADV20911.1 - 0.00017 21.9 0.0 0.00022 21.5 0.0 1.3 1 1 0 1 1 1 1 CENP-S protein Histone PF00125.24 ADV20911.1 - 0.0011 19.4 0.1 0.0012 19.2 0.1 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 ADV20911.1 - 0.0018 18.5 0.0 0.0029 17.9 0.0 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 ADV20911.1 - 0.071 13.2 0.0 0.08 13.0 0.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit GDI PF00996.18 ADV20912.1 - 3.7e-39 134.5 0.0 9.9e-39 133.1 0.0 1.5 1 1 0 1 1 1 1 GDP dissociation inhibitor NAD_binding_8 PF13450.6 ADV20912.1 - 0.00033 20.8 0.1 0.00073 19.7 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 ADV20912.1 - 0.00036 20.0 0.0 0.00045 19.7 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 ADV20912.1 - 0.0064 15.6 0.4 0.0092 15.1 0.4 1.2 1 0 0 1 1 1 1 FAD binding domain GIDA PF01134.22 ADV20912.1 - 0.061 12.4 0.1 0.087 11.9 0.1 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A Trp_halogenase PF04820.14 ADV20912.1 - 1.2 7.9 2.3 1.6 7.4 1.8 1.4 1 1 0 1 1 1 0 Tryptophan halogenase MutS_V PF00488.21 ADV20914.1 - 1.3e-63 214.5 0.0 2.7e-63 213.4 0.0 1.6 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 ADV20914.1 - 7.9e-35 120.8 0.2 2.2e-34 119.3 0.2 1.8 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.20 ADV20914.1 - 4.3e-27 94.6 0.2 1.5e-26 92.9 0.0 2.0 2 0 0 2 2 2 1 MutS domain I MutS_II PF05188.17 ADV20914.1 - 1e-09 38.8 0.0 3.3e-09 37.1 0.0 1.9 2 0 0 2 2 2 1 MutS domain II MutS_IV PF05190.18 ADV20914.1 - 0.00054 20.3 0.1 0.0015 18.8 0.1 1.8 1 0 0 1 1 1 1 MutS family domain IV AAA_27 PF13514.6 ADV20914.1 - 0.0035 16.9 0.0 0.0071 16.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 ADV20914.1 - 0.022 14.5 0.1 0.17 11.7 0.0 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_23 PF13476.6 ADV20914.1 - 0.052 14.0 0.3 0.28 11.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain LNP1 PF15419.6 ADV20915.1 - 0.15 12.3 5.9 0.17 12.1 0.2 3.1 3 0 0 3 3 3 0 Leukemia NUP98 fusion partner 1 HORMA PF02301.18 ADV20916.1 - 6.8e-25 87.9 0.0 8.6e-25 87.6 0.0 1.1 1 0 0 1 1 1 1 HORMA domain bacHORMA_2 PF18173.1 ADV20916.1 - 0.027 14.3 0.2 0.056 13.3 0.2 1.5 1 1 0 1 1 1 0 Bacterial HORMA domain 2 Pro_isomerase PF00160.21 ADV20917.1 - 6.3e-54 182.5 0.0 7.2e-54 182.3 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DUF676 PF05057.14 ADV20918.1 - 5e-06 26.2 0.0 2.2e-05 24.0 0.0 2.0 1 1 0 1 1 1 1 Putative serine esterase (DUF676) Palm_thioest PF02089.15 ADV20918.1 - 0.00018 21.4 0.0 0.00025 21.0 0.0 1.2 1 0 0 1 1 1 1 Palmitoyl protein thioesterase PGAP1 PF07819.13 ADV20918.1 - 0.00019 21.3 0.0 0.00037 20.3 0.0 1.4 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_1 PF00561.20 ADV20918.1 - 0.00033 20.4 0.1 0.0029 17.3 0.1 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold DUF915 PF06028.11 ADV20918.1 - 0.0015 17.9 0.0 0.0033 16.8 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) Abhydrolase_6 PF12697.7 ADV20918.1 - 0.0036 17.9 0.1 0.0036 17.9 0.1 1.9 2 1 0 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ADV20918.1 - 0.0045 16.3 0.3 0.015 14.6 0.0 1.9 3 0 0 3 3 3 1 Serine aminopeptidase, S33 LCAT PF02450.15 ADV20918.1 - 0.017 14.3 0.0 0.026 13.7 0.0 1.2 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase DUF900 PF05990.12 ADV20918.1 - 0.16 11.4 0.0 0.35 10.4 0.0 1.5 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF900) WD40 PF00400.32 ADV20919.1 - 1.4e-29 101.6 27.7 6.9e-07 29.9 0.6 7.4 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV20919.1 - 4.6e-16 58.9 0.1 1.2e-05 25.5 0.0 5.8 2 1 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ADV20919.1 - 1.3e-11 44.7 0.0 6.1e-06 26.2 0.0 3.2 1 1 2 4 4 4 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ADV20919.1 - 0.0005 19.1 0.2 0.032 13.2 0.0 2.4 2 0 0 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Coatomer_WDAD PF04053.14 ADV20919.1 - 0.012 14.7 0.0 0.016 14.3 0.0 1.1 1 0 0 1 1 1 0 Coatomer WD associated region Ribosomal_S10 PF00338.22 ADV20920.1 - 3.2e-28 97.8 0.1 3.8e-28 97.6 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e Myb_DNA-binding PF00249.31 ADV20921.1 - 7.2e-11 42.1 0.0 1.7e-10 40.9 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain SWIRM PF04433.17 ADV20921.1 - 2.1e-06 28.0 0.0 8.1e-06 26.1 0.0 2.0 1 0 0 1 1 1 1 SWIRM domain ZZ PF00569.17 ADV20921.1 - 2.5e-05 24.0 7.5 4.6e-05 23.1 7.5 1.4 1 0 0 1 1 1 1 Zinc finger, ZZ type Myb_DNA-bind_6 PF13921.6 ADV20921.1 - 0.0038 17.5 0.0 0.012 15.9 0.0 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain HVSL PF09749.9 ADV20922.1 - 4.7e-22 78.6 0.0 6e-22 78.3 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised conserved protein Cyclin_N PF00134.23 ADV20923.1 - 7.6e-05 22.5 0.0 0.00013 21.7 0.0 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain FlaC_arch PF05377.11 ADV20924.1 - 0.048 14.1 0.3 0.048 14.1 0.3 6.6 6 1 1 7 7 7 0 Flagella accessory protein C (FlaC) bZIP_2 PF07716.15 ADV20924.1 - 0.049 13.7 1.1 0.049 13.7 1.1 7.2 5 1 1 6 6 6 0 Basic region leucine zipper NPV_P10 PF05531.12 ADV20924.1 - 0.3 11.6 10.7 2.1 8.9 0.0 4.3 4 1 0 4 4 4 0 Nucleopolyhedrovirus P10 protein T3SS_needle_E PF08988.10 ADV20924.1 - 0.49 10.6 11.4 0.12 12.5 0.7 4.4 2 1 2 4 4 4 0 Type III secretion system, cytoplasmic E component of needle LPP PF04728.13 ADV20924.1 - 1.6 9.2 13.3 5.5 7.5 0.1 4.7 3 2 1 4 4 4 0 Lipoprotein leucine-zipper Bacillus_HBL PF05791.11 ADV20924.1 - 5.1 6.9 13.9 16 5.3 0.2 3.6 3 1 0 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) Spc7 PF08317.11 ADV20924.1 - 6 5.7 73.3 0.038 12.9 16.9 4.0 1 1 2 4 4 4 0 Spc7 kinetochore protein BRI3BP PF14965.6 ADV20924.1 - 6.2 6.3 7.0 0.87 9.1 0.2 2.7 3 0 0 3 3 3 0 Negative regulator of p53/TP53 DUF3425 PF11905.8 ADV20926.1 - 8.2e-15 54.9 0.0 3.3e-14 52.9 0.0 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF3425) bZIP_1 PF00170.21 ADV20926.1 - 1.2e-08 34.9 9.6 1.8e-07 31.2 9.3 2.2 1 1 1 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 ADV20926.1 - 0.015 15.4 3.3 0.015 15.4 3.3 2.2 1 1 1 2 2 2 0 Basic region leucine zipper DUF726 PF05277.12 ADV20927.1 - 2.9e-122 407.9 3.4 3.9e-122 407.5 3.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF726) TetR_C_24 PF17932.1 ADV20928.1 - 0.13 12.5 0.3 0.28 11.5 0.3 1.4 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain RIO1 PF01163.22 ADV20931.1 - 5.8e-49 166.2 0.1 1.2e-48 165.2 0.1 1.5 1 0 0 1 1 1 1 RIO1 family Rio2_N PF09202.11 ADV20931.1 - 1.6e-32 111.5 0.0 4.8e-32 110.0 0.0 1.8 1 0 0 1 1 1 1 Rio2, N-terminal APH PF01636.23 ADV20931.1 - 5.9e-10 39.5 0.2 0.00036 20.6 0.0 2.8 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 ADV20931.1 - 1.1e-05 24.9 1.1 0.044 13.1 0.0 2.6 3 0 0 3 3 3 2 Lipopolysaccharide kinase (Kdo/WaaP) family SMC_ScpB PF04079.16 ADV20931.1 - 0.13 11.9 0.0 0.24 11.0 0.0 1.3 1 0 0 1 1 1 0 Segregation and condensation complex subunit ScpB Peptidase_M41 PF01434.18 ADV20932.1 - 1.5e-61 207.6 0.4 2.6e-61 206.8 0.4 1.4 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 ADV20932.1 - 9.7e-42 142.5 0.0 2.3e-41 141.3 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ADV20932.1 - 1.5e-10 40.7 0.0 3.4e-10 39.6 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 ADV20932.1 - 6.3e-06 26.7 0.6 0.00028 21.3 0.4 3.0 2 1 0 2 2 1 1 AAA ATPase domain RuvB_N PF05496.12 ADV20932.1 - 0.0001 22.1 0.1 0.0005 19.8 0.0 2.2 3 0 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 ADV20932.1 - 0.00014 21.9 0.1 0.00082 19.4 0.1 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ADV20932.1 - 0.00017 21.9 1.5 0.0018 18.5 0.1 2.9 2 1 0 2 2 2 1 AAA domain TIP49 PF06068.13 ADV20932.1 - 0.00093 18.5 0.2 0.0019 17.5 0.0 1.5 2 0 0 2 2 2 1 TIP49 P-loop domain Mg_chelatase PF01078.21 ADV20932.1 - 0.0039 16.6 1.1 0.01 15.2 0.2 2.0 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 ADV20932.1 - 0.01 15.6 0.1 0.022 14.5 0.0 1.7 2 0 0 2 2 1 0 IstB-like ATP binding protein NACHT PF05729.12 ADV20932.1 - 0.012 15.5 0.1 0.07 13.0 0.1 2.2 1 1 0 1 1 1 0 NACHT domain AAA_33 PF13671.6 ADV20932.1 - 0.014 15.6 0.0 0.045 13.9 0.0 1.9 2 0 0 2 2 1 0 AAA domain AAA_2 PF07724.14 ADV20932.1 - 0.015 15.4 0.0 0.047 13.8 0.0 1.8 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_18 PF13238.6 ADV20932.1 - 0.016 15.8 0.0 0.036 14.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 ADV20932.1 - 0.02 14.6 0.0 0.32 10.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 ADV20932.1 - 0.032 14.5 0.2 0.1 12.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.13 ADV20932.1 - 0.04 13.1 0.0 0.077 12.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_7 PF12775.7 ADV20932.1 - 0.054 13.0 0.1 0.21 11.1 0.1 1.9 1 1 0 1 1 1 0 P-loop containing dynein motor region TsaE PF02367.17 ADV20932.1 - 0.056 13.4 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_25 PF13481.6 ADV20932.1 - 0.076 12.6 2.5 0.36 10.4 0.3 2.6 2 1 1 3 3 3 0 AAA domain Beta_protein PF14350.6 ADV20932.1 - 0.14 11.5 0.0 0.24 10.8 0.0 1.3 1 0 0 1 1 1 0 Beta protein AAA_30 PF13604.6 ADV20932.1 - 0.15 11.8 0.1 0.36 10.5 0.1 1.6 1 0 0 1 1 1 0 AAA domain BAG PF02179.16 ADV20932.1 - 0.15 12.5 2.6 17 5.9 0.0 2.4 2 0 0 2 2 2 0 BAG domain Sigma54_activat PF00158.26 ADV20932.1 - 0.16 11.7 0.0 0.4 10.4 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain MFS_1 PF07690.16 ADV20933.1 - 9e-36 123.5 16.8 9e-36 123.5 16.8 1.6 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ADV20933.1 - 4.8e-09 35.6 11.7 6.5e-09 35.2 11.7 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter RNase_PH PF01138.21 ADV20934.1 - 7.1e-18 65.4 0.0 1.1e-17 64.8 0.0 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 ADV20934.1 - 3.8e-09 36.5 0.0 6.9e-09 35.6 0.0 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 DnaJ_C PF01556.18 ADV20936.1 - 8.7e-35 120.0 0.0 1.2e-34 119.6 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 ADV20936.1 - 5.1e-25 87.4 3.6 8.1e-25 86.7 3.6 1.3 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 ADV20936.1 - 7.9e-11 42.2 19.5 1.4e-10 41.3 19.5 1.4 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 ADV20936.1 - 0.00088 19.2 14.4 0.061 13.3 2.8 2.5 2 0 0 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 ADV20936.1 - 0.76 9.8 10.0 1.1 9.3 1.7 2.3 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA TackOD1 PF18551.1 ADV20936.1 - 1.4 8.5 5.2 9.8 5.8 0.7 1.9 1 1 1 2 2 2 0 Thaumarchaeal output domain 1 RTA1 PF04479.13 ADV20937.1 - 4.2e-52 176.8 9.8 4.2e-52 176.8 9.8 1.5 2 0 0 2 2 2 1 RTA1 like protein DUF5353 PF17304.2 ADV20937.1 - 0.12 12.1 1.3 0.83 9.4 0.8 2.5 3 0 0 3 3 3 0 Family of unknown function (DUF5353) RTA1 PF04479.13 ADV20938.1 - 1e-55 188.6 9.5 1.8e-55 187.8 9.5 1.4 1 0 0 1 1 1 1 RTA1 like protein Cadherin_C_2 PF16492.5 ADV20938.1 - 0.078 13.7 0.1 0.21 12.3 0.1 1.8 1 0 0 1 1 1 0 Cadherin cytoplasmic C-terminal Pro_isomerase PF00160.21 ADV20938.1 - 0.18 12.1 0.0 0.29 11.4 0.0 1.3 1 0 0 1 1 1 0 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GATA PF00320.27 ADV20939.1 - 6.3e-05 22.5 2.6 0.00014 21.4 2.6 1.5 1 0 0 1 1 1 1 GATA zinc finger ADD_DNMT3 PF17980.1 ADV20939.1 - 0.083 12.9 0.1 0.14 12.1 0.1 1.3 1 0 0 1 1 1 0 Cysteine rich ADD domain in DNMT3 NMD3 PF04981.13 ADV20939.1 - 0.17 11.3 0.0 0.28 10.6 0.0 1.3 1 0 0 1 1 1 0 NMD3 family PPR_2 PF13041.6 ADV20941.1 - 6.4e-15 55.1 0.1 1.1e-11 44.7 0.1 2.8 2 0 0 2 2 2 2 PPR repeat family PPR_3 PF13812.6 ADV20941.1 - 0.00023 21.2 0.0 0.0043 17.1 0.0 2.6 2 0 0 2 2 2 1 Pentatricopeptide repeat domain PPR PF01535.20 ADV20941.1 - 0.0005 20.1 4.8 0.0029 17.7 0.1 3.9 4 0 0 4 4 4 1 PPR repeat PPR_1 PF12854.7 ADV20941.1 - 0.0041 16.8 0.2 4.1 7.2 0.0 3.4 3 0 0 3 3 3 1 PPR repeat PPR_long PF17177.4 ADV20941.1 - 0.093 12.1 0.0 0.73 9.1 0.0 2.5 4 0 0 4 4 4 0 Pentacotripeptide-repeat region of PRORP Bromodomain PF00439.25 ADV20942.1 - 7.8e-17 61.1 0.0 1.6e-16 60.2 0.0 1.5 1 0 0 1 1 1 1 Bromodomain CAF-1_p150 PF11600.8 ADV20942.1 - 1.1 8.9 7.2 0.32 10.7 3.0 2.2 2 0 0 2 2 2 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal WLM PF08325.10 ADV20943.1 - 4.7e-29 101.8 1.2 1.3e-28 100.4 1.2 1.9 1 1 0 1 1 1 1 WLM domain DUF45 PF01863.17 ADV20943.1 - 1.7e-06 28.2 2.2 2.8e-06 27.5 0.1 2.3 2 1 1 3 3 3 1 Protein of unknown function DUF45 SprT-like PF10263.9 ADV20943.1 - 0.001 18.9 0.0 0.0026 17.6 0.0 1.6 1 0 0 1 1 1 1 SprT-like family Porphobil_deam PF01379.20 ADV20945.1 - 1.3e-70 237.0 0.0 2e-70 236.4 0.0 1.3 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.15 ADV20945.1 - 2.8e-10 40.4 0.0 2.9e-07 30.8 0.3 2.6 2 0 0 2 2 2 2 Porphobilinogen deaminase, C-terminal domain VPS13_mid_rpt PF16910.5 ADV20946.1 - 1.7e-93 312.4 2.0 3.3e-90 301.6 0.0 4.6 3 1 0 4 4 4 1 Repeating coiled region of VPS13 VPS13 PF16908.5 ADV20946.1 - 3.3e-73 246.4 1.3 7.5e-70 235.4 0.1 3.6 3 0 0 3 3 3 1 Vacuolar sorting-associated protein 13, N-terminal SHR-BD PF06650.12 ADV20946.1 - 2.9e-72 243.3 0.0 1.3e-69 234.7 0.0 3.9 4 0 0 4 4 4 1 SHR-binding domain of vacuolar-sorting associated protein 13 VPS13_C PF16909.5 ADV20946.1 - 8.9e-68 227.6 5.6 9.2e-65 217.7 0.2 3.0 2 0 0 2 2 2 2 Vacuolar-sorting-associated 13 protein C-terminal Chorein_N PF12624.7 ADV20946.1 - 1.5e-28 99.2 0.0 6.4e-28 97.2 0.0 2.2 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 ATG_C PF09333.11 ADV20946.1 - 5.9e-10 39.4 0.0 1.1e-07 32.0 0.0 3.3 3 0 0 3 3 3 1 Autophagy-related protein C terminal domain SPT16 PF08644.11 ADV20947.1 - 5.9e-54 182.4 1.0 5.9e-54 182.4 1.0 2.0 2 0 0 2 2 2 1 FACT complex subunit (SPT16/CDC68) FACT-Spt16_Nlob PF14826.6 ADV20947.1 - 2.2e-41 141.3 0.0 5.6e-41 140.0 0.0 1.8 1 0 0 1 1 1 1 FACT complex subunit SPT16 N-terminal lobe domain Peptidase_M24 PF00557.24 ADV20947.1 - 5.1e-26 91.7 0.0 4e-25 88.7 0.0 2.2 2 0 0 2 2 2 1 Metallopeptidase family M24 Rtt106 PF08512.12 ADV20947.1 - 1.3e-16 60.8 0.0 4.6e-16 59.0 0.0 2.1 1 0 0 1 1 1 1 Histone chaperone Rttp106-like PH_TFIIH PF08567.11 ADV20947.1 - 0.0037 17.6 0.0 0.038 14.3 0.0 2.5 2 0 0 2 2 2 1 TFIIH p62 subunit, N-terminal domain HSP70 PF00012.20 ADV20948.1 - 3.1e-259 861.2 5.8 3.6e-259 861.0 5.8 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 ADV20948.1 - 8.7e-17 60.9 0.1 2.7e-15 56.0 0.0 2.2 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 ADV20948.1 - 0.0022 17.7 0.0 0.0051 16.6 0.0 1.6 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.6 ADV20948.1 - 0.0031 17.9 1.7 2.8 8.4 0.0 3.5 3 1 0 3 3 3 1 Cell division protein FtsA BcrAD_BadFG PF01869.20 ADV20948.1 - 0.0033 17.0 0.0 1.4 8.3 0.0 2.6 2 0 0 2 2 2 2 BadF/BadG/BcrA/BcrD ATPase family Hydantoinase_A PF01968.18 ADV20948.1 - 0.011 15.0 0.2 0.027 13.8 0.2 1.6 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase eIF3_subunit PF08597.10 ADV20948.1 - 0.49 10.3 9.7 0.15 11.9 6.6 1.6 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit Ubiq_cyt_C_chap PF03981.12 ADV20948.1 - 0.64 10.1 2.2 4.6 7.3 0.4 2.5 3 0 0 3 3 3 0 Ubiquinol-cytochrome C chaperone PIN_8 PF18476.1 ADV20948.1 - 2.8 7.7 6.4 6.9 6.5 0.1 2.3 2 0 0 2 2 2 0 PIN like domain DUF5082 PF16888.5 ADV20948.1 - 3.5 7.9 9.0 0.47 10.7 3.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) Stathmin PF00836.19 ADV20948.1 - 5 7.1 10.6 0.26 11.3 5.0 1.6 2 0 0 2 2 2 0 Stathmin family SH3_1 PF00018.28 ADV20949.1 - 2.5e-05 23.8 0.0 4.7e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ADV20949.1 - 0.0041 17.0 0.0 0.0069 16.2 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain HA2 PF04408.23 ADV20950.1 - 5.9e-27 94.1 0.1 5.9e-27 94.1 0.1 3.4 4 0 0 4 4 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 ADV20950.1 - 1.5e-20 73.3 0.0 4.4e-20 71.8 0.0 1.9 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 ADV20950.1 - 1.5e-10 41.4 0.0 4.2e-09 36.7 0.0 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 ADV20950.1 - 9.2e-10 38.6 0.0 1.9e-09 37.6 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 ADV20950.1 - 8.1e-06 26.2 0.0 6.3e-05 23.3 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 ADV20950.1 - 0.0012 19.2 0.0 0.0029 18.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain CDC45 PF02724.14 ADV20950.1 - 0.0022 16.4 14.5 0.0022 16.4 14.5 4.0 4 1 1 5 5 3 1 CDC45-like protein YL1 PF05764.13 ADV20950.1 - 0.0026 17.9 22.3 0.0026 17.9 22.3 5.0 4 1 1 5 5 3 1 YL1 nuclear protein AAA_30 PF13604.6 ADV20950.1 - 0.0051 16.5 0.0 0.012 15.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 ADV20950.1 - 0.01 15.1 0.0 0.025 13.8 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) ResIII PF04851.15 ADV20950.1 - 0.015 15.3 0.0 0.35 10.8 0.0 3.0 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit T2SSE PF00437.20 ADV20950.1 - 0.061 12.4 0.0 0.13 11.2 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.18 ADV20950.1 - 0.08 12.3 0.0 0.2 11.0 0.0 1.6 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_33 PF13671.6 ADV20950.1 - 0.12 12.5 0.0 0.35 11.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 ADV20950.1 - 0.13 12.8 0.0 0.13 12.8 0.0 4.6 4 1 0 5 5 3 0 AAA domain NPL4 PF05021.15 ADV20951.1 - 4.4e-115 384.3 0.0 5.3e-115 384.0 0.0 1.1 1 0 0 1 1 1 1 NPL4 family zf-NPL4 PF05020.15 ADV20951.1 - 3e-63 212.3 0.0 4.8e-63 211.6 0.0 1.3 1 0 0 1 1 1 1 NPL4 family, putative zinc binding region UN_NPL4 PF11543.8 ADV20951.1 - 0.00036 21.0 0.0 0.095 13.2 0.0 2.6 3 0 0 3 3 3 2 Nuclear pore localisation protein NPL4 HA2 PF04408.23 ADV20952.1 - 5.2e-19 68.5 0.0 5.2e-19 68.5 0.0 3.6 3 1 0 3 3 3 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 ADV20952.1 - 3.1e-18 65.9 0.0 7.3e-18 64.7 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 ADV20952.1 - 2.2e-15 57.0 0.1 7.3e-15 55.3 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 ADV20952.1 - 3.8e-08 33.3 0.0 1.6e-07 31.3 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.6 ADV20952.1 - 8.7e-05 22.8 0.1 0.00049 20.4 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 ADV20952.1 - 0.0006 20.2 0.6 0.0015 18.9 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 ADV20952.1 - 0.0027 17.4 0.0 0.0057 16.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain PWI PF01480.17 ADV20952.1 - 0.034 14.5 0.0 0.096 13.0 0.0 1.8 1 0 0 1 1 1 0 PWI domain T2SSE PF00437.20 ADV20952.1 - 0.035 13.1 0.0 0.075 12.1 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein FA_hydroxylase PF04116.13 ADV20953.1 - 3.6e-23 82.4 20.7 3.6e-23 82.4 20.7 1.8 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily zf-C3HC4_3 PF13920.6 ADV20954.1 - 1.3e-09 37.8 13.8 2e-09 37.1 13.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ADV20954.1 - 0.002 18.0 11.3 0.0037 17.1 11.3 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 SDA1 PF05285.12 ADV20954.1 - 0.21 11.0 6.2 0.31 10.4 6.2 1.2 1 0 0 1 1 1 0 SDA1 zf-RING_4 PF14570.6 ADV20954.1 - 1.9 8.4 12.4 3.7 7.4 12.4 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Cir_N PF10197.9 ADV20955.1 - 9.3e-05 22.5 2.1 9.3e-05 22.5 2.1 4.2 4 0 0 4 4 4 1 N-terminal domain of CBF1 interacting co-repressor CIR Baculo_F PF12259.8 ADV20955.1 - 0.47 8.9 2.6 0.69 8.4 2.6 1.2 1 0 0 1 1 1 0 Baculovirus F protein DUF3509 PF12021.8 ADV20956.1 - 0.05 13.4 0.0 0.06 13.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3509) NAD_Gly3P_dh_C PF07479.14 ADV20957.1 - 7.1e-45 152.8 0.1 1.1e-44 152.2 0.1 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus NAD_Gly3P_dh_N PF01210.23 ADV20957.1 - 3.3e-44 150.6 0.2 8.5e-44 149.3 0.1 1.6 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Rossmann-like PF10727.9 ADV20957.1 - 0.0018 18.2 0.2 0.07 13.0 0.1 2.4 2 0 0 2 2 2 1 Rossmann-like domain F420_oxidored PF03807.17 ADV20957.1 - 0.0033 18.0 2.7 0.075 13.6 1.5 2.7 2 1 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent DUF4354 PF14263.6 ADV20957.1 - 0.078 12.8 0.1 0.17 11.7 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4354) IlvN PF07991.12 ADV20957.1 - 0.084 12.4 0.2 13 5.4 0.1 2.4 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain MutL_C PF08676.11 ADV20958.1 - 6.5e-23 81.1 0.0 1.5e-22 80.0 0.0 1.5 1 0 0 1 1 1 1 MutL C terminal dimerisation domain DNA_mis_repair PF01119.19 ADV20958.1 - 2.9e-21 75.3 0.0 5.7e-21 74.4 0.0 1.5 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 ADV20958.1 - 7.6e-12 45.2 0.1 1.8e-11 44.0 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 ADV20958.1 - 1.5e-06 28.6 0.0 4.2e-06 27.2 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Glyco_hydro_3_C PF01915.22 ADV20959.1 - 3.5e-50 170.8 0.0 6.6e-50 169.9 0.0 1.5 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 ADV20959.1 - 3.5e-43 148.2 0.0 5.4e-43 147.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 ADV20959.1 - 1.4e-22 79.6 0.0 3.4e-22 78.3 0.0 1.7 1 0 0 1 1 1 1 Fibronectin type III-like domain B12D PF06522.11 ADV20960.1 - 0.021 14.6 0.2 0.031 14.1 0.2 1.2 1 0 0 1 1 1 0 NADH-ubiquinone reductase complex 1 MLRQ subunit Macoilin PF09726.9 ADV20961.1 - 1.9 6.9 20.9 2.3 6.7 20.9 1.0 1 0 0 1 1 1 0 Macoilin family PAT1 PF09770.9 ADV20961.1 - 2.5 6.3 15.8 2.9 6.0 15.8 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SOBP PF15279.6 ADV20961.1 - 5.2 7.6 11.1 6.7 7.2 11.1 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein Mito_carr PF00153.27 ADV20962.1 - 5.2e-57 189.8 1.1 6.3e-21 74.1 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Tim17 PF02466.19 ADV20962.1 - 0.0048 17.3 2.1 0.013 15.8 0.9 2.3 2 1 1 3 3 3 1 Tim17/Tim22/Tim23/Pmp24 family HSP70 PF00012.20 ADV20963.1 - 1.4e-259 862.4 5.2 1.6e-259 862.2 5.2 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 ADV20963.1 - 9.5e-17 60.8 0.2 5.8e-15 54.9 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.16 ADV20963.1 - 0.002 17.9 0.0 0.0049 16.6 0.0 1.7 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.6 ADV20963.1 - 0.01 16.2 3.0 3 8.3 0.0 3.5 3 2 0 3 3 3 0 Cell division protein FtsA DDR PF08841.10 ADV20963.1 - 0.012 14.6 0.4 0.17 10.8 0.2 2.1 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain Hydantoinase_A PF01968.18 ADV20963.1 - 0.023 14.0 0.2 0.055 12.7 0.2 1.7 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase Peptidase_M3_N PF08439.10 ADV20963.1 - 1.4 9.3 5.9 5.2 7.4 3.2 3.2 2 1 0 2 2 2 0 Oligopeptidase F Stathmin PF00836.19 ADV20963.1 - 3 7.8 9.3 0.19 11.7 3.9 1.7 2 0 0 2 2 2 0 Stathmin family eIF-1a PF01176.19 ADV20964.1 - 0.00021 21.0 0.0 0.00029 20.6 0.0 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 IBR PF01485.21 ADV20965.1 - 2.3e-14 53.4 16.2 2.5e-10 40.4 0.5 4.1 3 2 1 4 4 4 2 IBR domain, a half RING-finger domain RWD PF05773.22 ADV20965.1 - 3.1e-14 53.3 0.0 6.5e-14 52.2 0.0 1.5 1 0 0 1 1 1 1 RWD domain HAD_2 PF13419.6 ADV20966.1 - 1.5e-15 57.7 0.0 2.2e-15 57.2 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ADV20966.1 - 4e-08 33.8 0.0 2.4e-07 31.2 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ADV20966.1 - 0.0062 16.6 0.0 0.013 15.5 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 ADV20966.1 - 0.14 12.6 0.0 0.22 11.9 0.0 1.4 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase DUF2508 PF10704.9 ADV20966.1 - 0.21 11.8 0.0 0.38 10.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2508) MIP PF00230.20 ADV20968.1 - 2.1e-47 161.7 15.3 2.9e-47 161.3 15.3 1.1 1 0 0 1 1 1 1 Major intrinsic protein baeRF_family2 PF18844.1 ADV20968.1 - 0.019 15.0 0.1 0.029 14.4 0.1 1.2 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 2 Septin PF00735.18 ADV20969.1 - 4.7e-109 364.0 0.1 6.3e-109 363.6 0.1 1.1 1 0 0 1 1 1 1 Septin RsgA_GTPase PF03193.16 ADV20969.1 - 1.3e-08 35.0 0.1 2.5e-07 30.8 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 ADV20969.1 - 1.4e-08 34.8 0.0 3e-08 33.8 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ADV20969.1 - 5.2e-06 26.1 0.6 0.0014 18.2 0.0 2.8 2 2 0 2 2 2 1 Elongation factor Tu GTP binding domain Ras PF00071.22 ADV20969.1 - 0.00017 21.2 0.1 0.00056 19.6 0.1 1.9 1 1 0 1 1 1 1 Ras family AIG1 PF04548.16 ADV20969.1 - 0.00056 19.3 0.0 0.0015 17.9 0.0 1.7 2 0 0 2 2 2 1 AIG1 family AAA_16 PF13191.6 ADV20969.1 - 0.00073 20.0 0.1 0.0029 18.0 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain Roc PF08477.13 ADV20969.1 - 0.003 17.7 0.0 0.0068 16.6 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.6 ADV20969.1 - 0.0059 16.9 1.4 0.043 14.1 0.1 2.8 2 1 0 2 2 2 1 AAA domain ABC_tran PF00005.27 ADV20969.1 - 0.01 16.4 0.1 0.036 14.6 0.0 2.0 2 0 0 2 2 2 1 ABC transporter AAA_24 PF13479.6 ADV20969.1 - 0.017 14.9 1.9 0.055 13.2 0.2 2.4 2 1 0 2 2 2 0 AAA domain Gtr1_RagA PF04670.12 ADV20969.1 - 0.021 14.2 0.2 0.095 12.0 0.0 2.1 3 0 0 3 3 3 0 Gtr1/RagA G protein conserved region AAA_7 PF12775.7 ADV20969.1 - 0.021 14.3 0.0 0.043 13.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region PduV-EutP PF10662.9 ADV20969.1 - 0.022 14.5 2.3 0.35 10.6 0.5 2.7 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation NB-ARC PF00931.22 ADV20969.1 - 0.053 12.7 0.0 0.082 12.1 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain AAA_29 PF13555.6 ADV20969.1 - 0.068 12.9 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_25 PF13481.6 ADV20969.1 - 0.085 12.4 0.5 0.34 10.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 ADV20969.1 - 0.095 12.6 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 NACHT domain Casc1_N PF15927.5 ADV20969.1 - 0.11 12.1 9.4 0.27 10.9 9.4 1.6 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 N-terminus Pox_A32 PF04665.12 ADV20969.1 - 0.13 11.7 0.0 0.21 11.0 0.0 1.3 1 0 0 1 1 1 0 Poxvirus A32 protein FOXP-CC PF16159.5 ADV20969.1 - 0.13 12.9 0.8 0.43 11.2 0.8 1.9 1 0 0 1 1 1 0 FOXP coiled-coil domain MobB PF03205.14 ADV20969.1 - 0.14 12.0 0.2 0.52 10.2 0.2 2.0 1 1 1 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B FtsK_SpoIIIE PF01580.18 ADV20969.1 - 0.17 11.2 0.8 0.65 9.3 0.1 2.1 2 0 0 2 2 2 0 FtsK/SpoIIIE family Dynamin_N PF00350.23 ADV20969.1 - 0.19 11.8 3.8 2.6 8.1 0.1 3.0 2 1 1 3 3 3 0 Dynamin family FUSC PF04632.12 ADV20969.1 - 0.29 9.6 1.2 0.36 9.3 1.2 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family APG6_N PF17675.1 ADV20969.1 - 0.62 10.6 8.9 1.8 9.1 8.9 1.8 1 0 0 1 1 1 0 Apg6 coiled-coil region DegS PF05384.11 ADV20969.1 - 0.74 9.3 7.7 0.94 8.9 6.1 2.0 1 1 1 2 2 2 0 Sensor protein DegS Cep57_CLD_2 PF14197.6 ADV20969.1 - 4.2 7.5 8.0 0.53 10.4 3.4 1.9 2 0 0 2 2 1 0 Centrosome localisation domain of PPC89 LRR_4 PF12799.7 ADV20970.1 - 0.1 13.1 2.1 1.2 9.7 0.1 3.3 3 1 1 4 4 4 0 Leucine Rich repeats (2 copies) Prp19 PF08606.11 ADV20972.1 - 2.4e-28 97.9 2.9 4.6e-28 97.0 2.9 1.5 1 0 0 1 1 1 1 Prp19/Pso4-like WD40 PF00400.32 ADV20972.1 - 9.9e-26 89.5 6.6 2.7e-05 24.9 0.1 7.1 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV20972.1 - 1.4e-10 41.3 0.1 0.081 13.2 0.0 4.9 3 1 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain U-box PF04564.15 ADV20972.1 - 0.00056 20.0 0.0 0.001 19.2 0.0 1.4 1 0 0 1 1 1 1 U-box domain WD40_like PF17005.5 ADV20972.1 - 0.0064 15.9 0.0 0.47 9.7 0.0 2.2 2 0 0 2 2 2 1 WD40-like domain zf-Nse PF11789.8 ADV20972.1 - 0.047 13.5 0.0 0.091 12.6 0.0 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit eIF2A PF08662.11 ADV20972.1 - 0.059 13.2 0.0 1.4 8.7 0.0 2.7 2 1 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A DUF1631 PF07793.11 ADV20972.1 - 0.072 11.5 3.5 0.1 11.0 3.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1631) F-box-like PF12937.7 ADV20973.1 - 0.00066 19.5 0.0 0.0014 18.5 0.0 1.6 1 0 0 1 1 1 1 F-box-like LRR_8 PF13855.6 ADV20973.1 - 0.0075 16.0 2.8 1.3 8.8 0.0 3.9 4 0 0 4 4 4 1 Leucine rich repeat LRR_1 PF00560.33 ADV20973.1 - 0.013 15.9 2.2 1.3e+02 3.8 0.1 4.9 4 0 0 4 4 4 0 Leucine Rich Repeat TPR_1 PF00515.28 ADV20973.1 - 0.044 13.6 2.5 0.09 12.6 0.2 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 ADV20973.1 - 0.047 13.8 1.9 0.27 11.5 0.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat LRR_4 PF12799.7 ADV20973.1 - 0.15 12.5 10.1 0.22 12.0 0.1 4.6 6 0 0 6 6 6 0 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 ADV20973.1 - 1.3 9.2 7.3 5.3 7.4 0.2 4.1 5 0 0 5 5 5 0 Leucine Rich repeat DivIC PF04977.15 ADV20973.1 - 2.9 7.7 5.4 6.2 6.7 5.4 1.5 1 0 0 1 1 1 0 Septum formation initiator Pkinase PF00069.25 ADV20974.1 - 3.2e-63 213.6 0.0 6.3e-63 212.6 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV20974.1 - 4.5e-33 114.6 0.0 1.1e-32 113.4 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ADV20974.1 - 0.0045 15.8 0.3 0.0089 14.8 0.3 1.6 1 1 0 1 1 1 1 Fungal protein kinase RIO1 PF01163.22 ADV20974.1 - 0.013 15.1 0.1 0.026 14.1 0.1 1.4 1 0 0 1 1 1 0 RIO1 family Kinase-like PF14531.6 ADV20974.1 - 0.064 12.6 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Kinase-like DUF563 PF04577.14 ADV20975.1 - 1e-19 71.5 0.0 5.6e-19 69.1 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF563) TPM_phosphatase PF04536.14 ADV20975.1 - 0.055 13.6 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 TPM domain UEV PF05743.13 ADV20976.1 - 4.9e-36 123.2 0.0 8.2e-36 122.5 0.0 1.4 1 0 0 1 1 1 1 UEV domain Vps23_core PF09454.10 ADV20976.1 - 8.6e-27 92.9 0.4 1.5e-26 92.1 0.4 1.4 1 0 0 1 1 1 1 Vps23 core domain UQ_con PF00179.26 ADV20976.1 - 0.012 15.2 0.0 0.024 14.3 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-conjugating enzyme MbeD_MobD PF04899.12 ADV20976.1 - 0.041 14.0 0.2 0.11 12.7 0.2 1.7 1 0 0 1 1 1 0 MbeD/MobD like Dynamin_M PF01031.20 ADV20976.1 - 0.1 11.8 0.0 0.14 11.3 0.0 1.1 1 0 0 1 1 1 0 Dynamin central region TFIIA PF03153.13 ADV20976.1 - 2.9 7.8 7.9 3.6 7.5 7.9 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Rcd1 PF04078.13 ADV20977.1 - 4.6e-121 403.0 1.4 5.5e-121 402.8 1.4 1.1 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like Pigment_DH PF06324.11 ADV20977.1 - 0.16 12.1 0.8 0.6 10.3 0.3 2.3 2 0 0 2 2 2 0 Pigment-dispersing hormone (PDH) RIBIOP_C PF04950.12 ADV20978.1 - 5.3e-93 311.6 0.0 5.3e-93 311.6 0.0 2.0 2 0 0 2 2 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 ADV20978.1 - 1.4e-29 102.0 0.0 6.9e-29 99.8 0.0 2.3 2 0 0 2 2 2 1 AARP2CN (NUC121) domain MMR_HSR1 PF01926.23 ADV20978.1 - 0.00013 22.0 0.1 0.0003 20.8 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase RNA_helicase PF00910.22 ADV20978.1 - 0.00026 21.3 0.0 0.00067 20.0 0.0 1.7 1 0 0 1 1 1 1 RNA helicase AAA_16 PF13191.6 ADV20978.1 - 0.00027 21.3 0.0 0.001 19.5 0.0 1.9 2 0 0 2 2 1 1 AAA ATPase domain AAA_22 PF13401.6 ADV20978.1 - 0.00052 20.3 0.0 0.0015 18.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 ADV20978.1 - 0.00091 19.7 2.3 0.016 15.7 0.0 2.6 2 0 0 2 2 2 1 ABC transporter AAA_33 PF13671.6 ADV20978.1 - 0.0013 18.9 0.0 0.0053 16.9 0.0 2.1 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 ADV20978.1 - 0.0075 16.2 0.0 0.014 15.3 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA_18 PF13238.6 ADV20978.1 - 0.0076 16.8 0.1 0.0076 16.8 0.1 3.5 4 0 0 4 4 3 1 AAA domain AAA PF00004.29 ADV20978.1 - 0.0085 16.5 0.0 0.02 15.3 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.22 ADV20978.1 - 0.011 14.9 0.0 0.021 14.0 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain cobW PF02492.19 ADV20978.1 - 0.016 14.8 0.0 0.035 13.7 0.0 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain MobB PF03205.14 ADV20978.1 - 0.03 14.2 0.0 0.083 12.8 0.0 1.7 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B NTPase_1 PF03266.15 ADV20978.1 - 0.031 14.2 0.3 0.074 13.0 0.3 1.7 1 0 0 1 1 1 0 NTPase AAA_30 PF13604.6 ADV20978.1 - 0.039 13.7 0.0 0.084 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 ADV20978.1 - 0.061 13.6 0.0 0.25 11.6 0.0 2.1 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 ADV20978.1 - 0.066 13.2 0.1 0.2 11.7 0.1 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Roc PF08477.13 ADV20978.1 - 0.087 13.0 0.0 0.21 11.8 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_25 PF13481.6 ADV20978.1 - 0.11 12.1 0.0 0.3 10.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 ADV20978.1 - 0.18 12.2 1.8 0.2 12.0 0.1 1.9 2 0 0 2 2 1 0 AAA domain AAA_14 PF13173.6 ADV20978.1 - 0.41 10.7 1.9 1.1 9.3 0.0 2.5 2 0 0 2 2 2 0 AAA domain Acyltransferase PF01553.21 ADV20979.1 - 3.4e-08 33.2 0.0 7.1e-07 28.9 0.0 2.3 1 1 0 1 1 1 1 Acyltransferase DUF4603 PF15376.6 ADV20979.1 - 0.004 14.6 0.4 0.0057 14.1 0.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4603) eIF-5_eIF-2B PF01873.17 ADV20980.1 - 7.5e-39 132.2 0.0 1.3e-38 131.5 0.0 1.4 1 0 0 1 1 1 1 Domain found in IF2B/IF5 W2 PF02020.18 ADV20980.1 - 2.1e-22 79.1 0.6 2.1e-22 79.1 0.6 2.6 3 0 0 3 3 3 1 eIF4-gamma/eIF5/eIF2-epsilon Cys_rich_CPXG PF14255.6 ADV20980.1 - 0.023 14.6 0.2 0.044 13.7 0.2 1.5 1 0 0 1 1 1 0 Cysteine-rich CPXCG Zn_Tnp_IS1595 PF12760.7 ADV20980.1 - 0.2 11.7 0.3 0.39 10.7 0.3 1.5 1 0 0 1 1 1 0 Transposase zinc-ribbon domain PXA PF02194.15 ADV20981.1 - 5.4e-33 114.5 0.3 1.5e-32 113.1 0.3 1.7 1 0 0 1 1 1 1 PXA domain Nexin_C PF08628.12 ADV20981.1 - 4.3e-26 91.7 0.4 1.7e-25 89.8 0.0 2.4 2 0 0 2 2 2 1 Sorting nexin C terminal PX PF00787.24 ADV20981.1 - 5.6e-15 55.3 0.0 2.5e-14 53.2 0.0 2.2 2 0 0 2 2 2 1 PX domain RGS PF00615.19 ADV20981.1 - 3.2e-12 46.8 1.0 7.6e-11 42.3 0.0 3.2 3 0 0 3 3 3 1 Regulator of G protein signaling domain DUF4131 PF13567.6 ADV20981.1 - 5.3 6.7 6.5 12 5.5 6.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) Peptidase_M50B PF13398.6 ADV20982.1 - 2.2e-06 27.5 0.4 3.1e-06 27.0 0.4 1.2 1 0 0 1 1 1 1 Peptidase M50B-like DUF2157 PF09925.9 ADV20982.1 - 0.0011 18.8 0.1 0.0016 18.3 0.1 1.3 1 0 0 1 1 1 1 Predicted membrane protein (DUF2157) MS_channel PF00924.18 ADV20983.1 - 3.7e-25 88.7 1.6 6.1e-25 88.0 1.6 1.3 1 0 0 1 1 1 1 Mechanosensitive ion channel EF-hand_6 PF13405.6 ADV20983.1 - 0.019 14.9 0.0 0.045 13.7 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain EF-hand_1 PF00036.32 ADV20983.1 - 0.027 14.0 0.0 0.059 12.9 0.0 1.6 1 0 0 1 1 1 0 EF hand DUF1908 PF08926.11 ADV20984.1 - 1.3 8.1 4.8 2.8 7.0 4.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1908) Cse1 PF08506.10 ADV20986.1 - 6e-138 459.7 0.0 8.1e-138 459.3 0.0 1.2 1 0 0 1 1 1 1 Cse1 CAS_CSE1 PF03378.15 ADV20986.1 - 2.4e-128 428.4 0.0 5e-128 427.4 0.0 1.5 1 0 0 1 1 1 1 CAS/CSE protein, C-terminus IBN_N PF03810.19 ADV20986.1 - 5.2e-15 55.1 0.0 3.5e-14 52.5 0.0 2.6 1 0 0 1 1 1 1 Importin-beta N-terminal domain Hist_deacetyl PF00850.19 ADV20987.1 - 4.3e-82 276.0 0.0 6.6e-82 275.4 0.0 1.3 1 0 0 1 1 1 1 Histone deacetylase domain SNARE_assoc PF09335.11 ADV20988.1 - 2.4e-16 60.3 12.4 4.6e-14 52.9 6.4 3.5 4 0 0 4 4 4 2 SNARE associated Golgi protein PCI PF01399.27 ADV20989.1 - 0.00063 20.2 0.4 0.0032 18.0 0.1 2.3 3 0 0 3 3 3 1 PCI domain ThiF PF00899.21 ADV20992.1 - 3.7e-67 226.2 0.0 5.1e-67 225.8 0.0 1.1 1 0 0 1 1 1 1 ThiF family E2_bind PF08825.10 ADV20992.1 - 1.1e-22 79.9 0.0 1.8e-22 79.3 0.0 1.3 1 0 0 1 1 1 1 E2 binding domain Shikimate_DH PF01488.20 ADV20992.1 - 0.0069 16.5 0.5 0.016 15.3 0.0 1.8 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase UAE_UbL PF14732.6 ADV20992.1 - 0.015 15.9 0.0 0.031 14.9 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain PglD_N PF17836.1 ADV20992.1 - 0.048 14.3 0.1 0.11 13.2 0.1 1.6 1 0 0 1 1 1 0 PglD N-terminal domain Sacchrp_dh_NADP PF03435.18 ADV20992.1 - 0.059 13.6 0.7 0.61 10.4 0.0 2.6 3 0 0 3 3 3 0 Saccharopine dehydrogenase NADP binding domain UDPG_MGDP_dh_N PF03721.14 ADV20992.1 - 0.081 12.5 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Ecm33 PF12454.8 ADV20992.1 - 0.14 12.3 2.5 0.29 11.3 2.5 1.5 1 0 0 1 1 1 0 GPI-anchored cell wall organization protein ApbA PF02558.16 ADV20992.1 - 0.14 11.8 0.0 0.26 10.9 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Pyr_redox PF00070.27 ADV20992.1 - 0.17 12.5 0.0 0.32 11.6 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase UBA_e1_thiolCys PF10585.9 ADV20992.1 - 0.2 11.6 0.2 17 5.2 0.0 2.2 1 1 1 2 2 2 0 Ubiquitin-activating enzyme active site TMEM51 PF15345.6 ADV20993.1 - 0.0017 18.2 0.0 0.0033 17.3 0.0 1.4 1 0 0 1 1 1 1 Transmembrane protein 51 TMEM154 PF15102.6 ADV20993.1 - 0.0045 16.9 0.0 0.0081 16.1 0.0 1.4 1 0 0 1 1 1 1 TMEM154 protein family WBP-1 PF11669.8 ADV20993.1 - 0.076 13.6 0.0 0.13 12.9 0.0 1.3 1 0 0 1 1 1 0 WW domain-binding protein 1 DUF1180 PF06679.12 ADV20993.1 - 3.1 8.2 5.8 7.7 6.9 5.8 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1180) Oxidored_q3 PF00499.20 ADV20994.1 - 0.016 15.0 0.0 0.02 14.6 0.0 1.1 1 0 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 PEN-2 PF10251.9 ADV20994.1 - 0.36 11.3 3.2 1.6 9.2 3.2 1.9 1 1 0 1 1 1 0 Presenilin enhancer-2 subunit of gamma secretase DJ-1_PfpI PF01965.24 ADV20995.1 - 3.2e-13 49.8 0.0 1.6e-11 44.3 0.0 2.1 2 0 0 2 2 2 2 DJ-1/PfpI family ThiJ_like PF17124.5 ADV20995.1 - 2.5e-05 24.1 0.0 7.7e-05 22.5 0.0 1.8 1 1 0 1 1 1 1 ThiJ/PfpI family-like Sugar_tr PF00083.24 ADV20996.1 - 6.1e-53 180.3 29.8 3.4e-51 174.5 29.7 2.3 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ADV20996.1 - 8.1e-19 67.7 32.6 8.1e-19 67.7 32.6 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily Mito_carr PF00153.27 ADV20997.1 - 3e-67 222.6 1.3 4.7e-23 80.9 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_1 PF00036.32 ADV20997.1 - 7.9e-18 62.6 6.4 4.8e-07 28.9 0.0 5.5 6 0 0 6 6 6 3 EF hand EF-hand_6 PF13405.6 ADV20997.1 - 2.6e-16 58.1 5.7 2.1e-06 27.2 0.0 5.6 5 0 0 5 5 5 2 EF-hand domain EF-hand_7 PF13499.6 ADV20997.1 - 3.2e-14 53.1 7.1 1.1e-06 29.0 0.1 4.4 3 2 1 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 ADV20997.1 - 1.8e-11 43.0 6.4 2.9e-06 26.5 0.0 4.0 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 ADV20997.1 - 3.2e-06 26.9 6.1 0.13 12.2 0.0 4.4 5 0 0 5 5 5 3 EF-hand domain pair EF-hand_9 PF14658.6 ADV20997.1 - 0.051 13.9 0.1 10 6.5 0.0 3.6 4 0 0 4 4 4 0 EF-hand domain EF-hand_4 PF12763.7 ADV20997.1 - 0.12 12.3 0.2 1.2e+02 2.7 0.0 3.3 2 2 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand Dynactin PF12455.8 ADV20997.1 - 0.23 10.6 0.0 0.38 10.0 0.0 1.2 1 0 0 1 1 1 0 Dynein associated protein OTU PF02338.19 ADV20998.1 - 5e-15 56.1 0.0 9.4e-15 55.2 0.0 1.4 1 0 0 1 1 1 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 ADV20998.1 - 0.00018 21.1 0.0 0.1 12.1 0.0 2.3 2 0 0 2 2 2 2 Peptidase C65 Otubain Hydantoinase_B PF02538.14 ADV20999.1 - 3.8e-204 678.9 0.0 4.4e-204 678.7 0.0 1.0 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase DUF4227 PF14004.6 ADV21000.1 - 0.2 11.6 0.2 0.2 11.6 0.2 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF4227) CrgA PF06781.12 ADV21000.1 - 0.89 9.7 0.1 0.89 9.7 0.1 2.3 2 1 1 3 3 3 0 Cell division protein CrgA DUF2427 PF10348.9 ADV21000.1 - 1.1 9.1 4.2 0.22 11.3 0.6 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF2427) FA_desaturase PF00487.24 ADV21000.1 - 2 8.2 12.8 0.11 12.3 6.5 1.7 1 1 1 2 2 2 0 Fatty acid desaturase TPR_2 PF07719.17 ADV21001.1 - 0.00035 20.5 10.0 17 5.9 0.0 6.3 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_19 PF14559.6 ADV21001.1 - 0.0022 18.5 2.0 0.29 11.7 0.1 3.8 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 ADV21001.1 - 0.021 15.6 4.3 44 5.3 0.0 5.9 7 1 0 7 7 7 0 Tetratricopeptide repeat TPR_16 PF13432.6 ADV21001.1 - 0.083 13.5 5.7 50 4.7 0.0 4.8 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_11 PF13414.6 ADV21001.1 - 2.4 7.9 4.4 33 4.3 0.1 3.8 4 0 0 4 4 4 0 TPR repeat TPR_1 PF00515.28 ADV21001.1 - 6.3 6.8 7.1 24 4.9 0.3 4.7 6 0 0 6 6 6 0 Tetratricopeptide repeat DUF2264 PF10022.9 ADV21002.1 - 2.5e-130 434.7 0.0 3.1e-130 434.4 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2264) Cyt-b5 PF00173.28 ADV21003.1 - 7.3e-09 35.7 0.0 4.4e-08 33.1 0.0 1.9 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain APG6 PF04111.12 ADV21004.1 - 1.3e-42 145.8 0.0 1.3e-39 136.0 0.0 2.3 2 0 0 2 2 2 2 Apg6 BARA domain APG6_N PF17675.1 ADV21004.1 - 2.5e-14 54.0 14.3 3.9e-14 53.3 14.3 1.3 1 0 0 1 1 1 1 Apg6 coiled-coil region CHAD PF05235.14 ADV21004.1 - 0.14 12.1 3.9 0.27 11.2 3.9 1.4 1 0 0 1 1 1 0 CHAD domain HpcH_HpaI PF03328.14 ADV21005.1 - 4.9e-35 120.7 0.0 6.6e-35 120.2 0.0 1.1 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family Mito_carr PF00153.27 ADV21006.1 - 4.8e-17 61.7 0.0 3.2e-10 39.8 0.0 2.6 2 0 0 2 2 2 2 Mitochondrial carrier protein MMR_HSR1_Xtn PF16897.5 ADV21007.1 - 7.5e-39 132.0 0.2 1.4e-37 127.9 0.2 2.2 2 0 0 2 2 2 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 ADV21007.1 - 2.2e-24 85.3 0.1 4e-24 84.4 0.1 1.5 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.23 ADV21007.1 - 1.2e-19 70.4 0.2 2.7e-19 69.3 0.1 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ADV21007.1 - 2.5e-10 40.1 0.2 7.8e-10 38.5 0.0 1.9 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 ADV21007.1 - 0.0042 17.2 0.3 2.3 8.2 0.2 2.7 1 1 1 2 2 2 2 Dynamin family AAA_22 PF13401.6 ADV21007.1 - 0.027 14.7 0.1 0.19 12.0 0.0 2.2 1 1 0 2 2 2 0 AAA domain MeaB PF03308.16 ADV21007.1 - 0.057 12.4 0.1 0.12 11.3 0.1 1.5 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ATP_bind_1 PF03029.17 ADV21007.1 - 0.12 12.1 0.6 2.5 7.8 0.1 2.8 2 1 1 3 3 3 0 Conserved hypothetical ATP binding protein RsgA_GTPase PF03193.16 ADV21007.1 - 0.17 11.7 0.4 11 5.9 0.0 2.8 2 1 1 3 3 3 0 RsgA GTPase Ribosomal_L31 PF01197.18 ADV21008.1 - 0.014 15.6 0.0 0.026 14.7 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L31 PIF1 PF05970.14 ADV21009.1 - 7e-54 183.4 1.3 1.1e-42 146.5 0.2 2.2 1 1 0 2 2 2 2 PIF1-like helicase AAA_30 PF13604.6 ADV21009.1 - 8.1e-24 84.4 0.0 1.4e-23 83.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 ADV21009.1 - 2.1e-11 44.3 0.0 4.2e-11 43.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain Herpes_Helicase PF02689.14 ADV21009.1 - 3.2e-06 25.4 0.4 7.6e-05 20.8 0.0 2.3 2 0 0 2 2 2 1 Helicase AAA_7 PF12775.7 ADV21009.1 - 1.8e-05 24.3 0.0 4.5e-05 23.1 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_22 PF13401.6 ADV21009.1 - 3.4e-05 24.1 0.0 0.00015 22.0 0.0 2.1 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 ADV21009.1 - 5.5e-05 22.4 0.1 0.00018 20.7 0.1 1.7 2 0 0 2 2 2 1 Type II/IV secretion system protein Viral_helicase1 PF01443.18 ADV21009.1 - 0.00014 21.7 0.0 0.19 11.4 0.0 3.1 2 1 0 2 2 2 1 Viral (Superfamily 1) RNA helicase UvrD_C_2 PF13538.6 ADV21009.1 - 0.00016 21.4 0.0 0.00044 20.0 0.0 1.8 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_16 PF13191.6 ADV21009.1 - 0.00037 20.9 0.3 0.00094 19.6 0.0 1.8 2 0 0 2 2 1 1 AAA ATPase domain AAA_11 PF13086.6 ADV21009.1 - 0.0016 18.3 0.6 0.022 14.5 0.0 2.7 4 0 0 4 4 3 1 AAA domain DUF2075 PF09848.9 ADV21009.1 - 0.0036 16.6 0.1 0.016 14.5 0.0 2.2 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) PhoH PF02562.16 ADV21009.1 - 0.0056 16.2 0.1 0.028 13.9 0.0 2.1 2 0 0 2 2 2 1 PhoH-like protein AAA_5 PF07728.14 ADV21009.1 - 0.0066 16.5 0.0 0.029 14.4 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) NACHT PF05729.12 ADV21009.1 - 0.011 15.7 0.0 0.035 14.0 0.0 1.9 2 0 0 2 2 1 0 NACHT domain Mg_chelatase PF01078.21 ADV21009.1 - 0.023 14.1 0.0 0.044 13.2 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 ADV21009.1 - 0.03 14.7 0.0 0.2 12.1 0.0 2.4 2 1 0 2 2 2 0 RNA helicase Sigma54_activat PF00158.26 ADV21009.1 - 0.034 13.9 0.3 0.068 12.9 0.1 1.6 2 0 0 2 2 1 0 Sigma-54 interaction domain ATPase_2 PF01637.18 ADV21009.1 - 0.036 14.0 0.0 0.31 10.9 0.0 2.2 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea NB-ARC PF00931.22 ADV21009.1 - 0.037 13.2 0.0 0.066 12.4 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain TrwB_AAD_bind PF10412.9 ADV21009.1 - 0.038 12.9 0.0 0.062 12.2 0.0 1.3 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain AAA PF00004.29 ADV21009.1 - 0.04 14.3 0.0 0.1 13.0 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 ADV21009.1 - 0.04 14.4 0.0 0.22 12.1 0.0 2.2 2 0 0 2 2 2 0 ABC transporter RsgA_GTPase PF03193.16 ADV21009.1 - 0.047 13.6 0.1 0.1 12.5 0.1 1.5 1 0 0 1 1 1 0 RsgA GTPase DUF815 PF05673.13 ADV21009.1 - 0.053 12.7 0.1 0.11 11.6 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_14 PF13173.6 ADV21009.1 - 0.054 13.5 0.0 0.24 11.4 0.0 2.0 1 1 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 ADV21009.1 - 0.075 12.9 0.0 0.79 9.6 0.0 2.6 3 0 0 3 3 3 0 NTPase ResIII PF04851.15 ADV21009.1 - 0.093 12.7 0.1 0.22 11.5 0.1 1.6 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_29 PF13555.6 ADV21009.1 - 0.12 12.1 0.0 0.33 10.7 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain SH3_13 PF18335.1 ADV21009.1 - 0.15 11.9 0.2 2 8.3 0.1 2.4 2 0 0 2 2 2 0 ATP-dependent RecD-like DNA helicase SH3 domain TsaE PF02367.17 ADV21009.1 - 0.17 11.9 0.0 0.36 10.8 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE 2-Hacid_dh_C PF02826.19 ADV21011.1 - 6.6e-55 185.2 0.0 9.2e-55 184.7 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 ADV21011.1 - 2.4e-17 62.9 0.0 3.4e-17 62.4 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 ADV21011.1 - 3e-06 27.5 0.0 5e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 ADV21011.1 - 0.0038 17.8 0.0 0.011 16.3 0.0 1.9 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent IlvN PF07991.12 ADV21011.1 - 0.075 12.6 0.0 0.16 11.6 0.0 1.5 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain ApbA PF02558.16 ADV21011.1 - 0.12 12.0 0.0 0.21 11.2 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA DUF2076 PF09849.9 ADV21012.1 - 0.018 15.1 2.5 0.018 15.1 2.5 2.3 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2076) NDUF_C2 PF06374.11 ADV21014.1 - 3.8e-06 27.0 0.0 4.8e-06 26.7 0.0 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2) TraQ PF09679.10 ADV21014.1 - 0.058 13.3 0.0 0.074 13.0 0.0 1.2 1 0 0 1 1 1 0 Type-F conjugative transfer system pilin chaperone (TraQ) UPF1_Zn_bind PF09416.10 ADV21017.1 - 2.8e-72 241.7 7.7 2.8e-72 241.7 7.7 1.9 2 0 0 2 2 2 1 RNA helicase (UPF2 interacting domain) AAA_12 PF13087.6 ADV21017.1 - 7.6e-58 195.4 0.0 1.2e-57 194.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 ADV21017.1 - 9.3e-52 176.4 2.9 2.7e-29 102.8 0.3 2.3 1 1 1 2 2 2 2 AAA domain DUF5599 PF18141.1 ADV21017.1 - 3.8e-30 104.0 0.0 9e-30 102.8 0.0 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF5599) AAA_30 PF13604.6 ADV21017.1 - 5.6e-13 49.0 0.1 2.6e-12 46.9 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 ADV21017.1 - 1.7e-11 44.7 0.1 4.1e-11 43.4 0.1 1.6 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 ADV21017.1 - 6.6e-05 22.8 0.2 0.54 10.0 0.0 2.7 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase DUF2075 PF09848.9 ADV21017.1 - 0.00012 21.4 0.0 0.003 16.8 0.0 2.9 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) ResIII PF04851.15 ADV21017.1 - 0.00016 21.7 0.0 0.00029 20.9 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit UvrD-helicase PF00580.21 ADV21017.1 - 0.00046 19.8 0.0 0.026 14.1 0.0 2.7 2 1 0 3 3 3 1 UvrD/REP helicase N-terminal domain Helicase_RecD PF05127.14 ADV21017.1 - 0.00094 19.1 0.0 0.002 18.0 0.0 1.6 1 0 0 1 1 1 1 Helicase AAA_22 PF13401.6 ADV21017.1 - 0.007 16.6 0.0 0.019 15.2 0.0 1.8 1 0 0 1 1 1 1 AAA domain PhoH PF02562.16 ADV21017.1 - 0.019 14.4 0.0 0.082 12.3 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein DEAD PF00270.29 ADV21017.1 - 0.059 13.1 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 DEAD/DEAH box helicase ATPase PF06745.13 ADV21017.1 - 0.062 12.6 0.0 0.26 10.6 0.0 1.9 2 0 0 2 2 2 0 KaiC T2SSE PF00437.20 ADV21017.1 - 0.091 11.8 0.0 0.16 11.0 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_10 PF12846.7 ADV21017.1 - 0.1 11.5 0.0 0.16 10.9 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain PIF1 PF05970.14 ADV21017.1 - 0.11 11.6 0.0 8.6 5.4 0.0 2.3 2 1 0 2 2 2 0 PIF1-like helicase AAA_16 PF13191.6 ADV21017.1 - 0.12 12.8 0.9 0.6 10.5 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain AAA PF00004.29 ADV21017.1 - 0.19 12.2 0.0 0.42 11.0 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PRP3 PF08572.10 ADV21018.1 - 1.6e-67 227.5 9.1 1.6e-67 227.5 9.1 1.8 2 0 0 2 2 2 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.12 ADV21018.1 - 4e-42 143.8 0.1 4e-42 143.8 0.1 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1115) CDC37_N PF03234.14 ADV21018.1 - 6 7.8 9.2 4.4 8.2 6.2 2.3 2 0 0 2 2 2 0 Cdc37 N terminal kinase binding Ccdc124 PF06244.12 ADV21019.1 - 4.1e-24 85.6 18.8 4.1e-24 85.6 18.8 2.4 2 1 0 2 2 2 1 Coiled-coil domain-containing protein 124 /Oxs1 Trp_oprn_chp PF09534.10 ADV21020.1 - 0.047 13.5 0.4 0.047 13.5 0.4 1.8 2 0 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF2681 PF10883.8 ADV21020.1 - 0.09 13.2 1.0 0.18 12.2 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) Alpha_GJ PF03229.13 ADV21020.1 - 0.22 12.1 0.0 0.22 12.1 0.0 3.4 3 1 0 3 3 3 0 Alphavirus glycoprotein J LapA_dom PF06305.11 ADV21020.1 - 0.24 11.2 0.9 0.57 10.0 0.9 1.6 1 1 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Macoilin PF09726.9 ADV21020.1 - 3.2 6.2 9.6 5.5 5.4 9.6 1.4 1 0 0 1 1 1 0 Macoilin family Lin-8 PF03353.15 ADV21020.1 - 8.3 5.9 11.1 18 4.8 11.1 1.7 1 1 0 1 1 1 0 Ras-mediated vulval-induction antagonist ATP12 PF07542.11 ADV21021.1 - 1.8e-38 131.5 0.0 2.7e-38 131.0 0.0 1.3 1 0 0 1 1 1 1 ATP12 chaperone protein PK PF00224.21 ADV21022.1 - 2.1e-166 553.0 1.6 2.6e-166 552.7 1.6 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 ADV21022.1 - 2e-35 121.6 0.0 4.7e-35 120.3 0.0 1.7 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 ADV21022.1 - 2.9e-05 23.3 0.6 9.6e-05 21.6 0.7 1.8 1 1 1 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family IMPDH PF00478.25 ADV21022.1 - 0.036 13.0 0.1 0.35 9.8 0.0 2.1 2 0 0 2 2 2 0 IMP dehydrogenase / GMP reductase domain DUF3479 PF11965.8 ADV21022.1 - 0.15 12.1 0.0 0.38 10.9 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3479) DUF4112 PF13430.6 ADV21023.1 - 4.6e-33 113.6 0.1 8.3e-33 112.8 0.1 1.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4112) AbiEi_4 PF13338.6 ADV21023.1 - 0.1 12.8 0.0 0.24 11.6 0.0 1.6 1 0 0 1 1 1 0 Transcriptional regulator, AbiEi antitoxin Dabb PF07876.12 ADV21024.1 - 2e-15 57.2 0.0 2.3e-15 57.0 0.0 1.1 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain C2 PF00168.30 ADV21025.1 - 2.9e-93 307.0 0.1 1.2e-19 70.5 0.0 6.2 6 0 0 6 6 6 5 C2 domain PH_TFIIH PF08567.11 ADV21026.1 - 1.3e-12 47.9 0.0 2.2e-12 47.1 0.0 1.4 1 0 0 1 1 1 1 TFIIH p62 subunit, N-terminal domain BSD PF03909.17 ADV21026.1 - 2.6e-10 40.1 2.2 2.7e-07 30.5 0.3 2.9 3 0 0 3 3 3 2 BSD domain DUF1586 PF07625.11 ADV21026.1 - 0.27 11.3 2.5 0.41 10.8 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1586) Inositol_P PF00459.25 ADV21027.1 - 3.2e-54 184.3 0.0 3.8e-54 184.0 0.0 1.1 1 0 0 1 1 1 1 Inositol monophosphatase family Ribosomal_L1 PF00687.21 ADV21028.1 - 1.6e-20 73.7 0.0 2.2e-20 73.3 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family SRP54 PF00448.22 ADV21029.1 - 1.6e-47 161.7 0.8 4.7e-46 156.9 0.8 2.6 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain SRP-alpha_N PF04086.13 ADV21029.1 - 2e-34 119.8 0.0 7.6e-32 111.4 0.0 2.2 1 1 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal SRP54_N PF02881.19 ADV21029.1 - 1.5e-08 34.7 0.7 1.3e-07 31.7 0.0 2.7 3 0 0 3 3 3 1 SRP54-type protein, helical bundle domain MeaB PF03308.16 ADV21029.1 - 5.1e-05 22.4 0.1 0.00018 20.6 0.1 1.9 1 1 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_30 PF13604.6 ADV21029.1 - 0.0097 15.6 0.4 0.022 14.5 0.1 1.7 2 0 0 2 2 2 1 AAA domain CbiA PF01656.23 ADV21029.1 - 0.024 14.7 0.0 0.067 13.3 0.0 1.8 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Fer4_NifH PF00142.18 ADV21029.1 - 0.055 12.9 0.0 0.14 11.6 0.0 1.6 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family NTPase_1 PF03266.15 ADV21029.1 - 0.066 13.1 0.1 0.21 11.5 0.1 1.9 1 1 0 1 1 1 0 NTPase ArsA_ATPase PF02374.15 ADV21029.1 - 0.1 11.8 0.1 2.4 7.2 0.1 2.3 2 0 0 2 2 2 0 Anion-transporting ATPase AAA_31 PF13614.6 ADV21029.1 - 0.12 12.3 0.0 0.88 9.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain Ribosomal_L24e PF01246.20 ADV21031.1 - 5.7e-34 116.2 7.0 1.5e-33 114.8 7.0 1.7 1 0 0 1 1 1 1 Ribosomal protein L24e zf-FCS PF06467.14 ADV21031.1 - 0.38 10.7 6.7 0.67 9.9 6.7 1.4 1 0 0 1 1 1 0 MYM-type Zinc finger with FCS sequence motif TFIIS_C PF01096.18 ADV21032.1 - 1.2e-14 53.9 0.6 1.2e-14 53.9 0.6 2.8 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 ADV21032.1 - 5.8e-07 29.3 9.2 8.6e-07 28.7 0.5 3.0 2 1 1 3 3 3 1 RNA polymerases M/15 Kd subunit DZR PF12773.7 ADV21032.1 - 3.6e-06 26.9 6.3 0.0014 18.6 0.2 2.5 2 1 0 2 2 2 2 Double zinc ribbon HypA PF01155.19 ADV21032.1 - 0.0013 18.7 2.4 0.84 9.7 0.1 2.2 2 0 0 2 2 2 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_2 PF13240.6 ADV21032.1 - 0.0031 17.2 13.1 0.87 9.4 0.1 4.2 4 0 0 4 4 4 1 zinc-ribbon domain TF_Zn_Ribbon PF08271.12 ADV21032.1 - 0.0033 16.9 9.4 0.0045 16.5 0.4 3.3 3 1 0 3 3 3 1 TFIIB zinc-binding Zn-ribbon_8 PF09723.10 ADV21032.1 - 0.0051 16.9 11.2 2.9 8.1 2.6 3.9 3 1 1 4 4 4 1 Zinc ribbon domain TackOD1 PF18551.1 ADV21032.1 - 0.0099 15.6 3.8 1.5 8.4 0.7 2.2 1 1 1 2 2 2 2 Thaumarchaeal output domain 1 zf-ribbon_3 PF13248.6 ADV21032.1 - 0.011 15.1 14.4 0.19 11.2 0.2 4.1 3 1 1 4 4 4 0 zinc-ribbon domain zf-RING_7 PF02591.15 ADV21032.1 - 0.019 15.1 4.1 7.8 6.8 0.0 3.8 4 0 0 4 4 4 0 C4-type zinc ribbon domain Baculo_LEF5_C PF11792.8 ADV21032.1 - 0.023 14.4 0.6 0.023 14.4 0.6 2.8 2 1 1 3 3 3 0 Baculoviridae late expression factor 5 C-terminal domain Nudix_N_2 PF14803.6 ADV21032.1 - 0.037 13.9 11.8 0.38 10.7 3.7 3.8 3 1 0 3 3 3 0 Nudix N-terminal HscB_4_cys PF18256.1 ADV21032.1 - 0.11 12.4 8.3 2 8.3 0.1 4.1 4 0 0 4 4 4 0 Co-chaperone HscB tetracysteine metal binding motif IBR PF01485.21 ADV21032.1 - 0.16 12.2 6.7 0.24 11.6 0.1 2.7 2 1 0 2 2 2 0 IBR domain, a half RING-finger domain OrfB_Zn_ribbon PF07282.11 ADV21032.1 - 0.53 10.2 6.8 1.5 8.8 0.1 2.8 2 1 0 2 2 2 0 Putative transposase DNA-binding domain DNA_RNApol_7kD PF03604.13 ADV21032.1 - 0.61 9.8 10.9 10 5.9 0.2 3.5 3 1 0 3 3 3 0 DNA directed RNA polymerase, 7 kDa subunit A2L_zn_ribbon PF08792.10 ADV21032.1 - 0.71 9.7 9.8 15 5.5 0.1 4.0 4 0 0 4 4 4 0 A2L zinc ribbon domain Rubredoxin_2 PF18073.1 ADV21032.1 - 1 9.1 15.0 14 5.5 0.3 4.1 4 0 0 4 4 4 0 Rubredoxin metal binding domain Rpr2 PF04032.16 ADV21032.1 - 1.1 9.6 7.2 38 4.7 7.2 2.8 1 1 0 1 1 1 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain zf-C2H2_3 PF13878.6 ADV21032.1 - 1.2 9.0 9.8 2 8.3 0.2 3.6 3 1 1 4 4 4 0 zinc-finger of acetyl-transferase ESCO zinc_ribbon_4 PF13717.6 ADV21032.1 - 1.9 8.5 11.0 12 5.9 1.7 3.8 3 1 0 3 3 3 0 zinc-ribbon domain Auto_anti-p27 PF06677.12 ADV21032.1 - 2.2 8.5 8.7 0.41 10.8 0.7 2.7 2 1 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) DUF35_N PF12172.8 ADV21032.1 - 2.6 8.0 7.9 39 4.2 0.1 4.0 4 0 0 4 4 4 0 Rubredoxin-like zinc ribbon domain (DUF35_N) zinc_ribbon_5 PF13719.6 ADV21032.1 - 3.5 7.5 10.4 1 9.2 0.5 2.9 3 1 0 3 3 3 0 zinc-ribbon domain zf-HIT PF04438.16 ADV21032.1 - 4.7 7.2 9.8 11 6.0 0.2 3.9 4 0 0 4 4 4 0 HIT zinc finger Ribosomal_S27e PF01667.17 ADV21032.1 - 5.1 6.9 8.9 53 3.6 0.1 3.6 3 1 1 4 4 4 0 Ribosomal protein S27 XAF1_C PF18608.1 ADV21032.1 - 5.3 6.7 10.3 0.91 9.1 2.8 3.0 3 1 1 4 4 3 0 XIAP-associated factor 1 C-terminal domain GFA PF04828.14 ADV21032.1 - 5.8 7.3 7.4 9.4 6.7 0.5 3.2 1 1 2 3 3 3 0 Glutathione-dependent formaldehyde-activating enzyme zinc_ribbon_15 PF17032.5 ADV21032.1 - 6 7.7 11.0 60 4.5 5.5 3.2 1 1 0 2 2 2 0 zinc-ribbon family Mito_carr PF00153.27 ADV21033.1 - 9.6e-50 166.5 0.3 1e-17 63.8 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein CIAPIN1 PF05093.13 ADV21034.1 - 5.6e-34 116.6 3.6 8.7e-34 116.0 3.6 1.2 1 0 0 1 1 1 1 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis MRP-S28 PF10213.9 ADV21036.1 - 3.3e-36 124.5 0.0 4.5e-36 124.1 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit protein PheRS_DBD3 PF18553.1 ADV21036.1 - 0.17 12.2 0.0 7.3 7.0 0.0 2.3 2 0 0 2 2 2 0 PheRS DNA binding domain 3 Brix PF04427.18 ADV21038.1 - 4.1e-20 72.7 0.0 6.6e-20 72.0 0.0 1.3 1 0 0 1 1 1 1 Brix domain DUF1604 PF07713.13 ADV21038.1 - 0.85 9.5 3.5 3.4 7.6 3.5 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1604) SWIB PF02201.18 ADV21039.1 - 4.1e-29 100.3 1.1 6.6e-29 99.6 0.2 1.8 2 0 0 2 2 2 1 SWIB/MDM2 domain DEK_C PF08766.11 ADV21039.1 - 4e-06 26.6 0.2 1.9e-05 24.5 0.2 2.2 1 0 0 1 1 1 1 DEK C terminal domain NuDC PF16273.5 ADV21039.1 - 0.02 15.4 7.6 0.02 15.4 7.6 1.7 2 0 0 2 2 2 0 Nuclear distribution C domain Presenilin PF01080.17 ADV21039.1 - 4.3 6.0 5.4 5 5.8 5.4 1.1 1 0 0 1 1 1 0 Presenilin Thg1 PF04446.12 ADV21040.1 - 3e-50 169.5 0.1 4.5e-50 168.9 0.1 1.3 1 0 0 1 1 1 1 tRNAHis guanylyltransferase Thg1C PF14413.6 ADV21040.1 - 1.2e-43 148.1 0.0 1.8e-43 147.6 0.0 1.3 1 0 0 1 1 1 1 Thg1 C terminal domain SHE3 PF17078.5 ADV21041.1 - 0.068 12.9 0.8 0.11 12.2 0.8 1.4 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 RT_RNaseH_2 PF17919.1 ADV21042.1 - 3.3e-11 43.1 0.0 6.6e-11 42.1 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 ADV21042.1 - 1.1e-10 41.7 0.0 2.8e-10 40.4 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 ADV21042.1 - 4.9e-09 36.4 0.0 8.8e-09 35.6 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Cut8 PF08559.10 ADV21044.1 - 1.7e-05 24.6 0.2 3.6e-05 23.5 0.1 1.7 2 0 0 2 2 2 1 Cut8, nuclear proteasome tether protein 2-Hacid_dh_C PF02826.19 ADV21045.1 - 4.5e-40 136.9 0.0 6.7e-40 136.3 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 ADV21045.1 - 3e-25 88.4 0.0 3.6e-25 88.2 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain F420_oxidored PF03807.17 ADV21045.1 - 0.00097 19.7 0.0 0.0025 18.4 0.0 1.8 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent HTH_16 PF12645.7 ADV21046.1 - 0.077 13.1 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain PIG-X PF08320.12 ADV21047.1 - 0.077 12.9 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 PIG-X / PBN1 DIOX_N PF14226.6 ADV21048.1 - 4.6e-32 111.3 0.0 7.2e-32 110.6 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 ADV21048.1 - 4.1e-19 68.9 0.0 9.2e-19 67.8 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily PyrBI_leader PF08052.11 ADV21048.1 - 0.059 13.3 0.5 0.15 12.0 0.5 1.7 1 0 0 1 1 1 0 PyrBI operon leader peptide LETM1 PF07766.13 ADV21049.1 - 2.3e-101 338.6 1.0 2.3e-101 338.6 1.0 2.4 2 1 0 2 2 2 1 LETM1-like protein DUF1682 PF07946.14 ADV21049.1 - 0.041 13.1 9.3 0.13 11.4 9.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) EF-hand_7 PF13499.6 ADV21049.1 - 0.046 14.2 1.6 13 6.3 0.0 4.2 4 0 0 4 4 4 0 EF-hand domain pair ALMT PF11744.8 ADV21049.1 - 0.06 12.2 9.5 0.11 11.3 9.5 1.4 1 0 0 1 1 1 0 Aluminium activated malate transporter SAP PF02037.27 ADV21049.1 - 0.13 12.1 0.0 0.13 12.1 0.0 3.5 5 0 0 5 5 5 0 SAP domain Draxin PF15550.6 ADV21049.1 - 2.4 7.9 8.1 4.9 6.9 8.1 1.4 1 0 0 1 1 1 0 Draxin DUF4362 PF14275.6 ADV21049.1 - 3.1 8.2 5.9 13 6.1 0.0 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4362) Zn_clus PF00172.18 ADV21050.1 - 0.00027 21.0 12.9 0.00056 20.0 12.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 ADV21050.1 - 0.00063 18.8 0.1 0.0037 16.4 0.1 2.1 1 1 1 2 2 2 1 Fungal specific transcription factor domain Hydantoinase_A PF01968.18 ADV21051.1 - 5.3e-93 311.5 0.0 2.6e-92 309.2 0.0 1.9 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 ADV21051.1 - 2.6e-58 196.6 0.2 1e-55 188.2 0.0 2.3 2 0 0 2 2 2 2 Hydantoinase/oxoprolinase N-terminal region DUF4116 PF13475.6 ADV21051.1 - 0.11 12.3 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4116) NAD_binding_6 PF08030.12 ADV21052.1 - 6.1e-13 49.2 0.0 1.2e-11 45.0 0.0 2.1 1 1 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 ADV21052.1 - 0.014 15.5 0.0 0.027 14.5 0.0 1.5 1 0 0 1 1 1 0 FAD-binding domain NAD_binding_1 PF00175.21 ADV21052.1 - 0.026 15.2 0.0 3.6 8.3 0.0 2.4 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain MFS_1 PF07690.16 ADV21053.1 - 1.1e-14 54.2 37.3 1.1e-14 54.2 37.3 1.6 1 1 1 2 2 2 1 Major Facilitator Superfamily UNC-93 PF05978.16 ADV21053.1 - 5.5e-06 26.2 5.9 5.5e-06 26.2 5.9 3.1 3 2 0 3 3 3 1 Ion channel regulatory protein UNC-93 Glyco_hydro_28 PF00295.17 ADV21054.1 - 3.5e-35 121.6 0.3 5.9e-35 120.9 0.3 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Glyco_hydro_49 PF03718.13 ADV21054.1 - 0.016 15.2 3.0 0.34 10.9 0.9 3.2 2 1 1 3 3 3 0 Glycosyl hydrolase family 49 Tim17 PF02466.19 ADV21055.1 - 2.1e-32 111.8 8.1 2.5e-32 111.5 8.1 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family DEAD PF00270.29 ADV21056.1 - 2.1e-38 131.8 0.0 3.6e-38 131.1 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ADV21056.1 - 1.4e-22 80.1 0.0 7.5e-21 74.6 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ADV21056.1 - 1e-07 32.1 0.1 3.7e-07 30.3 0.0 1.9 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 ADV21056.1 - 0.036 14.3 0.7 0.59 10.4 0.7 2.3 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.6 ADV21056.1 - 0.045 14.1 0.0 0.09 13.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain CMS1 PF14617.6 ADV21056.1 - 4.7 6.5 19.1 15 4.8 0.0 3.3 3 0 0 3 3 3 0 U3-containing 90S pre-ribosomal complex subunit CDC27 PF09507.10 ADV21056.1 - 7.9 5.8 26.3 12 5.2 26.3 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 IF4E PF01652.18 ADV21057.1 - 5e-49 166.1 0.0 6.6e-49 165.7 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Tubulin PF00091.25 ADV21058.1 - 7.7e-70 235.1 0.0 9.4e-69 231.6 0.0 2.0 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ADV21058.1 - 2.9e-40 137.3 0.0 5.1e-40 136.5 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 ADV21058.1 - 4.9e-06 26.8 0.0 9.4e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 ADV21058.1 - 0.004 16.9 0.0 0.0075 16.0 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.6 ADV21058.1 - 0.041 13.1 0.0 0.068 12.3 0.0 1.3 1 0 0 1 1 1 0 Tubulin like GATA PF00320.27 ADV21059.1 - 3.5e-06 26.5 6.6 1.1e-05 24.9 6.6 1.9 1 1 0 1 1 1 1 GATA zinc finger EF_TS PF00889.19 ADV21060.1 - 2.1e-14 53.7 0.0 7.9e-10 38.7 0.0 2.6 1 1 1 2 2 2 2 Elongation factor TS Pyr_redox_2 PF07992.14 ADV21061.1 - 1.7e-46 158.8 0.0 2.4e-46 158.3 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Rieske PF00355.26 ADV21061.1 - 5.5e-17 61.5 0.0 1.4e-16 60.2 0.0 1.7 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Pyr_redox PF00070.27 ADV21061.1 - 7.4e-13 48.9 1.4 6.9e-10 39.4 0.1 3.3 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ADV21061.1 - 1.7e-09 37.4 0.4 2.1e-08 33.8 0.0 2.1 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 ADV21061.1 - 0.0017 17.6 0.2 0.28 10.3 0.0 2.4 2 1 1 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Reductase_C PF14759.6 ADV21061.1 - 0.018 15.6 0.0 0.041 14.4 0.0 1.6 1 0 0 1 1 1 0 Reductase C-terminal SF3b10 PF07189.11 ADV21063.1 - 5.2e-36 122.6 0.0 6.3e-36 122.3 0.0 1.0 1 0 0 1 1 1 1 Splicing factor 3B subunit 10 (SF3b10) PQ-loop PF04193.14 ADV21064.1 - 4.2e-36 122.5 7.7 6.8e-18 64.2 1.9 2.6 2 0 0 2 2 2 2 PQ loop repeat DARPP-32 PF05395.12 ADV21065.1 - 0.04 14.1 0.5 0.096 12.9 0.5 1.7 1 0 0 1 1 1 0 Protein phosphatase inhibitor 1/DARPP-32 EF1_GNE PF00736.19 ADV21066.1 - 9e-32 109.1 1.1 2.5e-31 107.7 1.1 1.8 1 0 0 1 1 1 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.9 ADV21066.1 - 4.6e-11 43.0 3.4 4.6e-11 43.0 3.4 3.1 2 1 1 3 3 3 1 Eukaryotic elongation factor 1 beta central acidic region Cwf_Cwc_15 PF04889.12 ADV21066.1 - 0.012 15.4 1.7 0.017 14.9 1.7 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein LRR_8 PF13855.6 ADV21067.1 - 2.3e-19 68.9 35.1 1.4e-05 24.7 1.7 7.3 6 1 2 8 8 8 5 Leucine rich repeat LRR_4 PF12799.7 ADV21067.1 - 4.4e-17 61.9 37.1 0.00015 22.1 0.6 9.5 5 1 6 11 11 11 8 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 ADV21067.1 - 3.5e-06 26.6 14.1 0.0035 16.9 0.5 4.5 4 1 1 5 5 5 3 Leucine-rich repeat LRR_6 PF13516.6 ADV21067.1 - 0.0037 17.2 19.2 6.5 7.1 0.2 8.6 9 0 0 9 9 9 1 Leucine Rich repeat DUF4054 PF13262.6 ADV21067.1 - 0.099 12.7 1.7 3 7.9 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4054) Fungal_trans PF04082.18 ADV21068.1 - 1.3e-12 47.4 0.0 2.7e-12 46.3 0.0 1.5 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ADV21068.1 - 2.3e-06 27.6 5.7 4.6e-06 26.7 5.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sortilin_C PF15901.5 ADV21068.1 - 0.044 14.1 0.3 0.073 13.4 0.3 1.3 1 0 0 1 1 1 0 Sortilin, neurotensin receptor 3, C-terminal Cep57_MT_bd PF06657.13 ADV21069.1 - 1.1e-22 80.2 0.6 1.1e-22 80.2 0.6 4.4 3 1 1 4 4 4 1 Centrosome microtubule-binding domain of Cep57 ADIP PF11559.8 ADV21069.1 - 0.015 15.4 13.3 0.048 13.8 1.0 2.7 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding DUF1192 PF06698.11 ADV21069.1 - 0.11 12.6 0.2 0.11 12.6 0.2 4.4 4 0 0 4 4 3 0 Protein of unknown function (DUF1192) DUF4407 PF14362.6 ADV21069.1 - 0.16 11.3 5.3 0.39 10.0 5.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF2203 PF09969.9 ADV21069.1 - 0.25 12.1 0.1 0.25 12.1 0.1 4.2 3 1 1 4 4 4 0 Uncharacterized conserved protein (DUF2203) FlxA PF14282.6 ADV21069.1 - 0.47 10.5 3.8 5.8 7.0 0.0 3.6 3 1 1 4 4 4 0 FlxA-like protein DivIC PF04977.15 ADV21069.1 - 0.52 10.1 10.2 0.73 9.7 0.0 3.8 5 0 0 5 5 5 0 Septum formation initiator SlyX PF04102.12 ADV21069.1 - 0.54 10.9 14.1 4.4 8.0 0.3 4.8 4 2 1 5 5 5 0 SlyX Mod_r PF07200.13 ADV21069.1 - 0.56 10.3 12.7 4.8 7.3 0.1 3.1 2 1 1 3 3 3 0 Modifier of rudimentary (Mod(r)) protein DUF5082 PF16888.5 ADV21069.1 - 0.78 10.0 3.5 4.3 7.6 0.5 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF5082) Syntaxin_2 PF14523.6 ADV21069.1 - 1.1 9.7 4.1 0.64 10.4 0.6 2.5 2 1 0 2 2 2 0 Syntaxin-like protein Atg14 PF10186.9 ADV21069.1 - 1.3 8.1 9.3 52 2.8 9.3 2.5 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 GrpE PF01025.19 ADV21069.1 - 1.4 8.6 18.2 1 9.0 1.9 2.8 2 1 1 3 3 3 0 GrpE Golgin_A5 PF09787.9 ADV21069.1 - 1.5 8.2 16.2 1.4 8.3 4.6 2.4 1 1 0 2 2 2 0 Golgin subfamily A member 5 Lzipper-MIP1 PF14389.6 ADV21069.1 - 4.6 7.6 8.9 0.17 12.2 0.6 2.9 4 0 0 4 4 2 0 Leucine-zipper of ternary complex factor MIP1 DUF16 PF01519.16 ADV21069.1 - 5.2 7.6 6.5 24 5.5 0.2 3.4 2 1 0 2 2 2 0 Protein of unknown function DUF16 Cep57_CLD PF14073.6 ADV21069.1 - 7 6.6 15.6 1 9.3 8.7 2.5 1 1 0 2 2 2 0 Centrosome localisation domain of Cep57 BST2 PF16716.5 ADV21069.1 - 7.2 7.3 11.1 0.16 12.5 0.4 3.4 2 1 0 3 3 3 0 Bone marrow stromal antigen 2 FapA PF03961.13 ADV21069.1 - 9.4 4.7 10.0 1.6 7.2 1.1 2.2 1 1 1 2 2 2 0 Flagellar Assembly Protein A BAR_2 PF10455.9 ADV21070.1 - 8.6e-49 166.2 0.0 2.7e-48 164.6 0.0 1.6 1 1 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR PF03114.18 ADV21070.1 - 1.3e-17 64.2 0.0 2.5e-14 53.5 0.0 2.0 2 0 0 2 2 2 2 BAR domain Peroxin-13_N PF04088.13 ADV21071.1 - 3.1e-39 134.5 0.0 4.2e-39 134.1 0.0 1.2 1 0 0 1 1 1 1 Peroxin 13, N-terminal region SH3_9 PF14604.6 ADV21071.1 - 6.4e-11 41.9 0.2 6.4e-11 41.9 0.2 1.9 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 ADV21071.1 - 5e-10 38.9 1.6 5.3e-10 38.8 0.2 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 ADV21071.1 - 9.2e-09 34.8 0.6 9.2e-09 34.8 0.6 1.6 2 0 0 2 2 2 1 SH3 domain Keratin_2_head PF16208.5 ADV21071.1 - 0.16 12.1 20.4 0.34 11.0 20.4 1.6 1 0 0 1 1 1 0 Keratin type II head MUG113 PF13455.6 ADV21072.1 - 5e-12 46.3 0.1 1.4e-11 44.9 0.1 1.9 1 1 0 1 1 1 1 Meiotically up-regulated gene 113 T5orf172 PF10544.9 ADV21072.1 - 4.8e-09 36.7 0.7 9.6e-08 32.5 0.7 2.8 1 1 0 1 1 1 1 T5orf172 domain A_deaminase PF00962.22 ADV21073.1 - 1.8e-125 418.7 0.5 2.8e-125 418.0 0.5 1.3 1 0 0 1 1 1 1 Adenosine/AMP deaminase Pyr_redox_3 PF13738.6 ADV21074.1 - 3.1e-19 69.4 0.0 2e-16 60.2 0.0 2.4 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 ADV21074.1 - 4.4e-15 55.1 0.0 5.3e-11 41.6 0.0 2.2 2 0 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 ADV21074.1 - 2.1e-12 46.9 0.0 1.2e-08 34.5 0.0 3.0 2 1 1 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 ADV21074.1 - 3.5e-08 33.1 0.0 2.2e-05 23.9 0.1 2.3 2 0 0 2 2 2 2 FAD binding domain Pyr_redox PF00070.27 ADV21074.1 - 2.3e-07 31.2 0.1 0.01 16.3 0.2 3.4 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 ADV21074.1 - 3e-07 29.9 0.0 4e-05 22.9 0.0 2.9 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 ADV21074.1 - 9.7e-05 22.5 0.0 0.014 15.6 0.0 2.6 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 ADV21074.1 - 0.0024 16.6 0.0 0.037 12.7 0.1 2.5 3 0 0 3 3 3 1 HI0933-like protein Thi4 PF01946.17 ADV21074.1 - 0.0035 16.6 0.0 2.2 7.5 0.0 2.4 2 0 0 2 2 2 2 Thi4 family FAD_oxidored PF12831.7 ADV21074.1 - 0.042 13.2 0.0 3.8 6.7 0.1 2.3 2 0 0 2 2 2 0 FAD dependent oxidoreductase 2-Hacid_dh_C PF02826.19 ADV21074.1 - 0.07 12.5 0.0 2.9 7.2 0.0 2.3 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DAO PF01266.24 ADV21074.1 - 0.12 11.9 1.9 2.2 7.8 0.2 3.3 2 2 0 4 4 4 0 FAD dependent oxidoreductase GIDA PF01134.22 ADV21074.1 - 0.22 10.6 0.0 1.6 7.8 0.0 2.3 2 1 0 2 2 2 0 Glucose inhibited division protein A NAD_binding_9 PF13454.6 ADV21074.1 - 0.26 11.3 2.1 16 5.4 0.6 3.2 3 1 0 3 3 3 0 FAD-NAD(P)-binding DDE_Tnp_4 PF13359.6 ADV21075.1 - 2.9e-09 36.8 0.0 6.1e-09 35.7 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_1 PF01609.21 ADV21075.1 - 8.2e-05 22.3 0.0 0.00013 21.7 0.0 1.3 1 0 0 1 1 1 1 Transposase DDE domain adh_short_C2 PF13561.6 ADV21076.1 - 2.4e-30 105.8 0.0 7.4e-30 104.2 0.0 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ADV21076.1 - 1.3e-27 96.6 0.0 1.9e-27 96.0 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ADV21076.1 - 1.9e-10 40.9 0.0 3.1e-10 40.3 0.0 1.3 1 0 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 ADV21076.1 - 0.005 16.3 0.0 0.0073 15.7 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Lon_C PF05362.13 ADV21076.1 - 0.04 13.5 0.0 0.063 12.8 0.0 1.3 1 0 0 1 1 1 0 Lon protease (S16) C-terminal proteolytic domain 3Beta_HSD PF01073.19 ADV21076.1 - 0.05 12.6 0.0 0.16 10.9 0.0 1.8 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 ADV21076.1 - 0.1 12.0 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 ADV21076.1 - 0.13 12.5 0.0 0.24 11.6 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Urocanase PF01175.18 ADV21076.1 - 0.14 11.8 0.0 0.23 11.1 0.0 1.3 1 0 0 1 1 1 0 Urocanase Rossmann-like domain Cpn60_TCP1 PF00118.24 ADV21078.1 - 8.3e-149 496.3 0.7 9.4e-149 496.2 0.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family EAL PF00563.20 ADV21078.1 - 0.037 13.6 0.0 0.072 12.6 0.0 1.4 1 0 0 1 1 1 0 EAL domain Zn_clus PF00172.18 ADV21079.1 - 1.3e-07 31.6 9.1 2.1e-07 31.0 9.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ribonuclease_3 PF00636.26 ADV21080.1 - 4e-28 98.1 0.0 5.7e-17 62.3 0.0 2.6 2 0 0 2 2 2 2 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 ADV21080.1 - 1.7e-13 50.9 0.1 2.4e-06 27.7 0.0 4.1 4 0 0 4 4 4 3 Ribonuclease-III-like Dicer_dimer PF03368.14 ADV21080.1 - 1.8e-07 31.2 0.1 1e-06 28.8 0.0 2.2 2 0 0 2 2 2 1 Dicer dimerisation domain Ribonuclease_3 PF00636.26 ADV21081.1 - 7e-27 94.1 0.0 3.9e-17 62.8 0.0 2.5 2 0 0 2 2 2 2 Ribonuclease III domain Dicer_dimer PF03368.14 ADV21081.1 - 4.3e-12 46.0 0.1 8.3e-11 41.9 0.0 2.7 2 0 0 2 2 2 1 Dicer dimerisation domain Ribonucleas_3_3 PF14622.6 ADV21081.1 - 5.6e-09 36.2 0.0 0.0043 17.2 0.0 4.0 4 0 0 4 4 4 3 Ribonuclease-III-like DUF3981 PF13139.6 ADV21082.1 - 0.13 12.6 0.0 0.14 12.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3981) adh_short_C2 PF13561.6 ADV21083.1 - 3.6e-36 124.9 0.0 1.1e-35 123.3 0.0 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ADV21083.1 - 9.4e-35 119.8 0.0 1.5e-34 119.2 0.0 1.3 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ADV21083.1 - 9.7e-08 32.1 0.1 2e-07 31.1 0.1 1.4 1 0 0 1 1 1 1 KR domain WG_beta_rep PF14903.6 ADV21083.1 - 0.0056 16.9 0.0 0.014 15.6 0.0 1.7 1 0 0 1 1 1 1 WG containing repeat adh_short PF00106.25 ADV21084.1 - 9.4e-33 113.3 0.0 1.3e-32 112.8 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ADV21084.1 - 4e-29 101.8 0.0 1.1e-28 100.4 0.0 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ADV21084.1 - 6.7e-06 26.1 0.4 7e-05 22.8 0.0 2.1 2 0 0 2 2 2 1 KR domain Ribosomal_L7Ae PF01248.26 ADV21085.1 - 1.9e-25 88.4 2.3 2.5e-25 88.0 2.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Med8 PF10232.9 ADV21085.1 - 0.08 12.5 0.1 0.094 12.3 0.1 1.1 1 0 0 1 1 1 0 Mediator of RNA polymerase II transcription complex subunit 8 SpoU_sub_bind PF08032.12 ADV21085.1 - 0.11 12.8 0.3 0.71 10.2 0.1 2.0 1 1 1 2 2 2 0 RNA 2'-O ribose methyltransferase substrate binding Prenyltrans PF00432.21 ADV21086.1 - 8.8e-26 89.4 3.4 1.9e-07 30.7 0.0 3.4 3 0 0 3 3 3 3 Prenyltransferase and squalene oxidase repeat Mucin PF01456.17 ADV21087.1 - 1.2 9.1 19.9 2.9 7.9 19.9 1.6 1 1 0 1 1 1 0 Mucin-like glycoprotein CEL_III_C PF18054.1 ADV21087.1 - 2.7 8.1 6.2 3.9 7.5 6.2 1.2 1 0 0 1 1 1 0 CEL-III C-terminal GRAB PF10375.9 ADV21088.1 - 3.1e-07 30.0 2.5 3.1e-07 30.0 2.5 2.4 2 0 0 2 2 2 1 GRIP-related Arf-binding domain ZapB PF06005.12 ADV21088.1 - 0.0052 17.2 5.4 0.0052 17.2 5.4 6.0 3 1 2 5 5 3 2 Cell division protein ZapB GRIP PF01465.20 ADV21088.1 - 0.028 14.3 0.0 0.071 13.0 0.0 1.7 1 0 0 1 1 1 0 GRIP domain Cep57_MT_bd PF06657.13 ADV21088.1 - 0.032 14.7 2.6 0.032 14.7 2.6 4.6 1 1 4 5 5 5 0 Centrosome microtubule-binding domain of Cep57 Spc7 PF08317.11 ADV21088.1 - 0.055 12.3 43.4 0.0098 14.8 13.9 2.7 1 1 2 3 3 3 0 Spc7 kinetochore protein FPP PF05911.11 ADV21088.1 - 0.56 8.3 47.4 0.43 8.7 21.9 2.2 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil HOOK PF05622.12 ADV21088.1 - 0.87 7.7 48.5 1.8 6.6 7.3 3.1 1 1 2 3 3 3 0 HOOK protein PI_PP_I PF18363.1 ADV21088.1 - 1.3 9.2 3.1 3.5 7.9 0.2 2.8 2 2 1 3 3 3 0 Phosphoinositide phosphatase insertion domain Zw10 PF06248.13 ADV21088.1 - 2.2 6.8 15.7 0.87 8.1 12.8 1.4 1 1 0 1 1 1 0 Centromere/kinetochore Zw10 DUF1664 PF07889.12 ADV21088.1 - 4.8 7.2 15.4 0.58 10.2 1.7 3.3 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) Filament PF00038.21 ADV21088.1 - 5.1 6.6 46.9 1.9 8.0 35.4 3.0 1 1 1 2 2 2 0 Intermediate filament protein Laminin_II PF06009.12 ADV21088.1 - 5.8 6.9 21.2 0.91 9.5 3.8 2.5 2 0 0 2 2 2 0 Laminin Domain II Syntaxin-6_N PF09177.11 ADV21088.1 - 6.9 7.3 26.4 4.7 7.8 11.3 3.8 1 1 1 3 3 3 0 Syntaxin 6, N-terminal Macoilin PF09726.9 ADV21088.1 - 8.7 4.8 45.8 0.015 13.9 23.1 2.3 1 1 1 2 2 1 0 Macoilin family DUF4201 PF13870.6 ADV21088.1 - 8.8 6.0 36.9 5 6.8 5.1 3.7 1 1 2 3 3 3 0 Domain of unknown function (DUF4201) ATP-synt_G PF04718.15 ADV21089.1 - 1.6e-12 48.1 1.9 4.2e-12 46.8 0.1 2.1 1 1 1 2 2 2 1 Mitochondrial ATP synthase g subunit HBM PF16591.5 ADV21089.1 - 0.099 12.1 0.0 0.13 11.7 0.0 1.1 1 0 0 1 1 1 0 Helical bimodular sensor domain tRNA_synthFbeta PF17759.1 ADV21090.1 - 4.6e-43 147.2 0.0 6.4e-43 146.7 0.0 1.2 1 0 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain PhetRS_B1 PF18262.1 ADV21090.1 - 8.6e-30 102.8 0.1 4e-29 100.7 0.1 2.1 2 0 0 2 2 2 1 Phe-tRNA synthetase beta subunit B1 domain B3_4 PF03483.17 ADV21090.1 - 1.1e-21 77.2 0.0 2.3e-21 76.3 0.0 1.5 1 0 0 1 1 1 1 B3/4 domain B5 PF03484.15 ADV21090.1 - 6.8e-17 61.5 0.0 5.6e-15 55.4 0.0 2.8 2 0 0 2 2 2 1 tRNA synthetase B5 domain DUF469 PF04320.14 ADV21090.1 - 0.19 12.6 0.5 0.39 11.6 0.5 1.5 1 0 0 1 1 1 0 Protein with unknown function (DUF469) MipZ PF09140.11 ADV21090.1 - 0.24 10.7 0.0 0.48 9.7 0.0 1.4 1 0 0 1 1 1 0 ATPase MipZ NAD_binding_11 PF14833.6 ADV21091.1 - 5.9e-27 94.3 0.0 1.3e-26 93.3 0.0 1.5 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase NAD_binding_2 PF03446.15 ADV21091.1 - 3.6e-20 72.7 1.4 8.2e-18 65.1 1.4 2.8 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase ABC_membrane_2 PF06472.15 ADV21092.1 - 3.8e-84 282.3 0.1 6.2e-84 281.6 0.1 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 ADV21092.1 - 9.2e-20 71.6 0.0 2.1e-19 70.4 0.0 1.7 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ADV21092.1 - 0.00011 22.2 0.0 0.00032 20.6 0.0 1.8 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ADV21092.1 - 0.029 13.8 0.0 0.25 10.7 0.0 2.1 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain Rad17 PF03215.15 ADV21092.1 - 0.039 13.9 0.0 0.087 12.7 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_29 PF13555.6 ADV21092.1 - 0.054 13.2 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 ADV21092.1 - 0.23 11.8 1.1 0.83 10.0 0.2 2.2 2 0 0 2 2 2 0 AAA ATPase domain AAA_23 PF13476.6 ADV21092.1 - 0.24 11.9 0.0 0.24 11.9 0.0 2.8 4 0 0 4 4 4 0 AAA domain AAA_15 PF13175.6 ADV21092.1 - 1.2 8.7 5.8 0.65 9.6 0.1 2.8 4 0 0 4 4 4 0 AAA ATPase domain Pho88 PF10032.9 ADV21093.1 - 9.7e-75 249.8 0.1 1.1e-74 249.7 0.1 1.0 1 0 0 1 1 1 1 Phosphate transport (Pho88) Oxidored_FMN PF00724.20 ADV21094.1 - 1.2e-16 60.9 0.0 2.7e-16 59.8 0.0 1.5 1 1 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Aa_trans PF01490.18 ADV21096.1 - 5.7e-05 22.0 13.1 0.012 14.3 9.0 2.7 2 1 0 2 2 2 2 Transmembrane amino acid transporter protein UPF0121 PF03661.13 ADV21097.1 - 2e-39 135.5 2.9 2.7e-39 135.0 2.9 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0121) SET PF00856.28 ADV21098.1 - 5.3e-05 23.7 0.0 5.3e-05 23.7 0.0 3.1 2 1 0 2 2 2 1 SET domain CENP-B_dimeris PF09026.10 ADV21098.1 - 9.1 6.7 10.3 16 6.0 0.3 2.8 2 0 0 2 2 2 0 Centromere protein B dimerisation domain UDPGP PF01704.18 ADV21099.1 - 1.6e-198 659.4 0.1 1.9e-198 659.2 0.1 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase DnaJ PF00226.31 ADV21100.1 - 9.3e-17 60.9 0.3 1.5e-16 60.2 0.3 1.3 1 0 0 1 1 1 1 DnaJ domain Peptidase_M3 PF01432.20 ADV21102.1 - 6.2e-118 395.0 0.0 2e-117 393.3 0.0 1.6 1 1 0 1 1 1 1 Peptidase family M3 Peptidase_M91 PF14891.6 ADV21102.1 - 0.22 11.8 0.0 0.39 11.0 0.0 1.3 1 0 0 1 1 1 0 Effector protein Sugar_tr PF00083.24 ADV21104.1 - 2e-106 356.6 18.5 2.8e-106 356.1 18.5 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ADV21104.1 - 4.4e-33 114.7 42.0 3.8e-29 101.7 24.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 ADV21104.1 - 0.0056 15.6 11.4 0.28 10.0 3.1 3.3 2 2 1 3 3 3 2 MFS_1 like family DUF21 PF01595.20 ADV21104.1 - 7.1 6.3 8.0 0.24 11.1 0.3 2.4 3 0 0 3 3 3 0 Cyclin M transmembrane N-terminal domain PX PF00787.24 ADV21105.1 - 5.3e-21 74.7 0.0 1.3e-20 73.5 0.0 1.6 1 0 0 1 1 1 1 PX domain Vps5 PF09325.10 ADV21105.1 - 0.081 12.5 3.5 0.057 13.0 0.4 2.1 2 0 0 2 2 2 0 Vps5 C terminal like FAM92 PF06730.11 ADV21105.1 - 0.14 11.5 1.9 0.21 11.0 0.4 1.9 2 0 0 2 2 2 0 FAM92 protein STAT_alpha PF01017.20 ADV21105.1 - 0.75 9.7 6.1 0.11 12.4 1.4 2.0 2 0 0 2 2 2 0 STAT protein, all-alpha domain Ank_2 PF12796.7 ADV21106.1 - 4.1e-21 75.4 0.1 1.7e-13 51.0 0.0 2.4 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ADV21106.1 - 6.6e-20 70.9 2.7 2.6e-10 40.3 0.1 4.2 3 2 1 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 ADV21106.1 - 4.9e-15 55.7 1.8 3.3e-09 37.1 0.1 3.4 2 2 3 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 ADV21106.1 - 7.4e-15 53.6 0.6 0.0012 19.2 0.0 4.8 5 0 0 5 5 5 3 Ankyrin repeat Ank PF00023.30 ADV21106.1 - 1e-13 51.0 1.1 0.00029 21.1 0.0 4.4 4 0 0 4 4 4 2 Ankyrin repeat Proteasome PF00227.26 ADV21107.1 - 4.4e-43 147.0 0.2 6.5e-43 146.4 0.2 1.3 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.8 ADV21107.1 - 3.4e-14 51.9 0.5 3.4e-14 51.9 0.5 1.6 2 0 0 2 2 2 1 Proteasome beta subunits C terminal Aldo_ket_red PF00248.21 ADV21108.1 - 4.6e-30 104.8 0.0 1.4e-29 103.2 0.0 1.6 1 1 0 1 1 1 1 Aldo/keto reductase family DUF1195 PF06708.11 ADV21108.1 - 0.082 12.7 0.1 0.75 9.6 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1195) GN3L_Grn1 PF08701.11 ADV21109.1 - 3.9e-23 81.3 17.5 3.9e-23 81.3 17.5 3.4 4 0 0 4 4 4 1 GNL3L/Grn1 putative GTPase MMR_HSR1 PF01926.23 ADV21109.1 - 1.9e-10 40.8 0.0 8.1e-08 32.3 0.0 2.7 2 1 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ADV21109.1 - 0.00026 20.9 0.0 0.048 13.6 0.0 2.9 3 0 0 3 3 3 1 RsgA GTPase GTP_EFTU PF00009.27 ADV21109.1 - 0.00033 20.3 0.0 0.12 11.9 0.0 2.7 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain AIG1 PF04548.16 ADV21109.1 - 0.00048 19.5 0.0 0.0016 17.8 0.0 1.9 2 0 0 2 2 2 1 AIG1 family FeoB_N PF02421.18 ADV21109.1 - 0.0013 18.3 1.2 1.3 8.5 0.0 3.2 3 0 0 3 3 3 2 Ferrous iron transport protein B Septin PF00735.18 ADV21109.1 - 0.0031 16.8 0.0 0.0072 15.6 0.0 1.6 1 0 0 1 1 1 1 Septin Dynamin_N PF00350.23 ADV21109.1 - 0.025 14.6 3.7 13 5.8 0.6 3.7 2 2 0 2 2 2 0 Dynamin family AAA_16 PF13191.6 ADV21109.1 - 0.028 14.8 0.0 0.094 13.1 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain cobW PF02492.19 ADV21109.1 - 0.031 13.9 0.2 4.1 6.9 0.0 2.5 2 1 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ox_reductase_C PF08635.10 ADV21110.1 - 1.7e-73 244.9 0.1 2.7e-73 244.3 0.1 1.3 1 0 0 1 1 1 1 Putative oxidoreductase C terminal domain GFO_IDH_MocA PF01408.22 ADV21110.1 - 3.5e-22 79.5 0.0 5.7e-22 78.8 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold BTB PF00651.31 ADV21111.1 - 0.00084 19.5 0.0 0.0014 18.8 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Glyco_transf_22 PF03901.17 ADV21113.1 - 1.2e-36 126.9 12.7 1.4e-36 126.6 12.7 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family Hepar_II_III PF07940.13 ADV21115.1 - 3.1e-11 43.4 1.6 6e-11 42.4 1.6 1.4 1 0 0 1 1 1 1 Heparinase II/III-like protein NOT2_3_5 PF04153.18 ADV21116.1 - 1.2e-21 77.2 0.1 1.2e-21 77.2 0.1 1.8 2 0 0 2 2 2 1 NOT2 / NOT3 / NOT5 family HAMP PF00672.25 ADV21117.1 - 1.9e-42 143.4 15.8 7.2e-08 32.7 0.1 8.2 7 0 0 7 7 7 7 HAMP domain HATPase_c PF02518.26 ADV21117.1 - 3.1e-30 105.0 0.1 1.1e-29 103.2 0.0 2.0 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ADV21117.1 - 6.5e-23 81.0 0.1 3.6e-22 78.7 0.1 2.4 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 ADV21117.1 - 3.9e-16 58.8 0.3 3e-15 56.0 0.3 2.7 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain DUF1843 PF08898.10 ADV21117.1 - 0.0012 19.3 4.0 0.94 10.0 0.0 6.2 7 1 1 8 8 8 1 Domain of unknown function (DUF1843) WXG100 PF06013.12 ADV21117.1 - 0.01 16.0 9.9 17 5.7 0.0 6.7 7 0 0 7 7 7 0 Proteins of 100 residues with WXG HATPase_c_3 PF13589.6 ADV21117.1 - 0.017 14.9 0.0 0.042 13.7 0.0 1.7 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF4795 PF16043.5 ADV21117.1 - 0.39 10.3 4.2 3.6 7.2 0.2 3.3 3 1 0 3 3 3 0 Domain of unknown function (DUF4795) CENP-F_leu_zip PF10473.9 ADV21117.1 - 3.4 7.7 16.7 2.4 8.2 2.2 5.6 6 0 0 6 6 6 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 LPP PF04728.13 ADV21117.1 - 6.6 7.2 5.8 8 6.9 0.8 3.9 3 0 0 3 3 3 0 Lipoprotein leucine-zipper R3H PF01424.22 ADV21118.1 - 1.3e-11 44.3 0.0 4e-11 42.7 0.0 2.0 1 0 0 1 1 1 1 R3H domain G-patch PF01585.23 ADV21118.1 - 3.5e-08 33.2 0.6 1e-07 31.7 0.6 1.9 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 ADV21118.1 - 0.0023 18.0 0.6 0.0023 18.0 0.6 2.7 2 0 0 2 2 2 1 G-patch domain Zn_clus PF00172.18 ADV21119.1 - 1.2e-06 28.6 9.9 1.9e-06 27.9 9.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pkinase PF00069.25 ADV21120.1 - 2.9e-61 207.1 0.0 5.5e-61 206.2 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV21120.1 - 1.7e-35 122.6 0.0 3e-35 121.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.22 ADV21120.1 - 8.4e-22 76.8 28.7 1.1e-12 47.6 8.8 2.5 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) HR1 PF02185.16 ADV21120.1 - 5.5e-17 61.6 14.8 8.9e-09 35.3 6.4 2.7 2 0 0 2 2 2 2 Hr1 repeat Pkinase_C PF00433.24 ADV21120.1 - 4.6e-11 43.2 0.6 1.3e-10 41.7 0.6 1.9 1 0 0 1 1 1 1 Protein kinase C terminal domain C2 PF00168.30 ADV21120.1 - 5e-06 26.8 0.0 9.1e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 C2 domain FTA2 PF13095.6 ADV21120.1 - 0.015 15.0 0.2 0.44 10.1 0.0 2.5 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 ADV21120.1 - 0.03 13.3 0.1 0.054 12.4 0.1 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Kinase-like PF14531.6 ADV21120.1 - 0.088 12.1 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Kinase-like DUF4407 PF14362.6 ADV21120.1 - 0.31 10.4 3.8 1 8.7 1.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) HBM PF16591.5 ADV21120.1 - 1 8.7 5.7 3.8 6.9 0.2 2.2 2 0 0 2 2 2 0 Helical bimodular sensor domain C1_2 PF03107.16 ADV21120.1 - 2.9 8.3 23.6 0.68 10.3 7.3 2.5 2 0 0 2 2 2 0 C1 domain MFS_1 PF07690.16 ADV21121.1 - 6.7e-50 170.0 43.0 3.5e-49 167.6 42.3 2.0 2 0 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 ADV21121.1 - 1.9e-18 66.3 22.4 2.7e-18 65.7 22.4 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 ADV21121.1 - 9.9e-10 37.8 13.8 9.9e-10 37.8 13.8 3.0 2 2 0 3 3 3 2 Sugar (and other) transporter Rotamase_3 PF13616.6 ADV21123.1 - 1.6e-19 70.6 0.0 5e-19 69.0 0.0 1.7 1 1 0 1 1 1 1 PPIC-type PPIASE domain Rotamase PF00639.21 ADV21123.1 - 1.3e-18 67.7 0.0 2.1e-18 67.1 0.0 1.4 1 0 0 1 1 1 1 PPIC-type PPIASE domain WW PF00397.26 ADV21123.1 - 1.4e-05 25.0 0.7 2.7e-05 24.2 0.7 1.4 1 0 0 1 1 1 1 WW domain Rotamase_2 PF13145.6 ADV21123.1 - 0.00068 20.5 0.0 0.0017 19.2 0.0 1.7 1 1 0 1 1 1 1 PPIC-type PPIASE domain WW_1 PF18507.1 ADV21123.1 - 0.0073 16.0 0.1 0.015 15.0 0.1 1.5 1 0 0 1 1 1 1 WW domain DUF1993 PF09351.10 ADV21123.1 - 0.15 12.2 0.0 0.22 11.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1993) Vps35 PF03635.17 ADV21124.1 - 0 1034.2 0.0 0 1034.0 0.0 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 Sugar_tr PF00083.24 ADV21125.1 - 5.4e-100 335.4 15.4 6.3e-100 335.2 15.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ADV21125.1 - 2.3e-27 95.9 48.9 8.6e-24 84.1 23.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2737 PF10930.8 ADV21125.1 - 0.22 11.1 0.1 0.41 10.3 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2737) Relaxase PF03432.14 ADV21126.1 - 0.00023 20.9 2.3 0.00023 20.9 2.3 1.5 2 0 0 2 2 2 1 Relaxase/Mobilisation nuclease domain TUDOR PF00567.24 ADV21126.1 - 0.012 15.7 0.0 0.023 14.7 0.0 1.5 1 0 0 1 1 1 0 Tudor domain Tudor_3 PF18115.1 ADV21126.1 - 0.046 13.6 0.0 0.078 12.8 0.0 1.3 1 0 0 1 1 1 0 DNA repair protein Crb2 Tudor domain Lsr2 PF11774.8 ADV21126.1 - 0.24 11.6 0.0 0.24 11.6 0.0 2.1 2 0 0 2 2 2 0 Lsr2 Cnd1_N PF12922.7 ADV21126.1 - 4.1 7.2 6.8 3.9 7.3 0.1 2.1 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1, N-term Mitoc_mL59 PF18126.1 ADV21126.1 - 5.7 7.3 14.0 3.3 8.0 9.0 2.3 2 0 0 2 2 2 0 Mitochondrial ribosomal protein mL59 Vps51 PF08700.11 ADV21127.1 - 7.1e-18 64.5 0.0 1.6e-17 63.4 0.0 1.5 1 0 0 1 1 1 1 Vps51/Vps67 COG5 PF10392.9 ADV21127.1 - 0.013 15.6 3.1 0.026 14.7 0.3 2.2 1 1 1 2 2 2 0 Golgi transport complex subunit 5 Laminin_II PF06009.12 ADV21127.1 - 0.019 15.0 0.1 0.045 13.8 0.1 1.7 1 1 0 1 1 1 0 Laminin Domain II EVE PF01878.18 ADV21128.1 - 4.4e-36 124.1 0.0 7.8e-36 123.2 0.0 1.4 1 0 0 1 1 1 1 EVE domain TAFII28 PF04719.14 ADV21129.1 - 5.8e-21 74.4 0.0 8.7e-21 73.8 0.0 1.2 1 0 0 1 1 1 1 hTAFII28-like protein conserved region DNA_pol_phi PF04931.13 ADV21129.1 - 8.5 4.3 8.4 11 3.9 8.4 1.1 1 0 0 1 1 1 0 DNA polymerase phi SNF2_N PF00176.23 ADV21130.1 - 2.9e-34 118.4 0.0 2.5e-17 62.7 0.1 2.6 1 1 1 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.31 ADV21130.1 - 7.2e-15 55.3 0.0 1.5e-14 54.3 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 ADV21130.1 - 4.9e-08 32.5 0.0 1.4e-07 31.0 0.0 1.7 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 DUF2439 PF10382.9 ADV21130.1 - 0.0011 19.2 0.1 0.0031 17.8 0.1 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF2439) ResIII PF04851.15 ADV21130.1 - 0.061 13.3 0.0 0.18 11.8 0.0 1.8 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit MatB PF16449.5 ADV21131.1 - 0.023 14.5 3.8 1.6 8.5 0.0 2.4 1 1 1 2 2 2 0 Fimbrillin MatB SR-25 PF10500.9 ADV21131.1 - 2.6 7.6 12.0 3.7 7.1 12.0 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Sugar_tr PF00083.24 ADV21132.1 - 1.9e-51 175.3 17.6 2.5e-51 174.9 17.6 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ADV21132.1 - 3.4e-26 92.0 33.7 4e-24 85.2 20.5 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily Aminotran_5 PF00266.19 ADV21133.1 - 1.1e-13 51.0 0.0 4.5e-13 48.9 0.0 2.0 1 1 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 ADV21133.1 - 0.066 11.7 0.0 0.11 11.0 0.0 1.3 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme DUF4722 PF15849.5 ADV21133.1 - 0.072 12.8 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4722) DHDPS PF00701.22 ADV21134.1 - 8.8e-38 129.7 0.0 1.1e-37 129.4 0.0 1.1 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family HIG_1_N PF04588.13 ADV21135.1 - 5.7e-17 61.7 0.6 8e-17 61.2 0.6 1.2 1 0 0 1 1 1 1 Hypoxia induced protein conserved region SelP_N PF04592.14 ADV21135.1 - 0.00061 19.3 0.0 0.00089 18.7 0.0 1.2 1 0 0 1 1 1 1 Selenoprotein P, N terminal region Methyltransf_10 PF05971.12 ADV21136.1 - 2.1e-63 214.4 0.0 2.7e-63 214.1 0.0 1.1 1 0 0 1 1 1 1 RNA methyltransferase MTS PF05175.14 ADV21136.1 - 5.5e-06 26.0 0.0 1.5e-05 24.6 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.6 ADV21136.1 - 0.013 15.3 0.0 0.022 14.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_18 PF12847.7 ADV21136.1 - 0.025 14.5 0.0 0.043 13.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain PrmA PF06325.13 ADV21136.1 - 0.038 13.4 0.0 0.055 12.9 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 ADV21136.1 - 0.06 14.1 0.0 0.17 12.6 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 ADV21136.1 - 0.24 11.1 0.0 0.52 10.0 0.0 1.5 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CoaE PF01121.20 ADV21137.1 - 3.2e-54 183.3 0.0 4.4e-54 182.9 0.0 1.2 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_18 PF13238.6 ADV21137.1 - 5.3e-06 27.0 0.0 5.3e-06 27.0 0.0 2.1 2 1 0 2 2 2 1 AAA domain SKI PF01202.22 ADV21137.1 - 0.002 18.3 0.0 0.017 15.2 0.0 2.1 2 0 0 2 2 2 1 Shikimate kinase Cytidylate_kin2 PF13189.6 ADV21137.1 - 0.028 14.6 0.5 0.043 14.0 0.0 1.7 2 1 0 2 2 2 0 Cytidylate kinase-like family AAA_17 PF13207.6 ADV21137.1 - 0.081 13.3 0.0 0.19 12.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 ADV21137.1 - 0.11 12.7 0.0 0.31 11.2 0.0 2.0 1 1 0 1 1 1 0 AAA domain Cytidylate_kin PF02224.18 ADV21137.1 - 0.17 11.6 0.0 0.31 10.7 0.0 1.4 1 0 0 1 1 1 0 Cytidylate kinase NPR2 PF06218.11 ADV21138.1 - 4.8e-84 282.7 0.5 5.1e-68 229.8 0.3 3.2 1 1 1 2 2 2 2 Nitrogen permease regulator 2 BCS1_N PF08740.11 ADV21139.1 - 3.9e-51 173.7 0.2 5.3e-51 173.3 0.2 1.2 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 ADV21139.1 - 1.3e-19 70.9 0.0 2.3e-19 70.1 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ADV21139.1 - 0.0007 19.6 0.1 0.0035 17.4 0.0 2.1 2 1 1 3 3 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ADV21139.1 - 0.0007 20.0 0.1 0.0027 18.1 0.0 2.1 2 1 0 2 2 2 1 AAA ATPase domain AAA_21 PF13304.6 ADV21139.1 - 0.0069 16.2 0.1 0.015 15.2 0.1 1.7 1 1 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_18 PF13238.6 ADV21139.1 - 0.01 16.3 0.0 0.026 15.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 ADV21139.1 - 0.019 14.5 0.0 0.032 13.8 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_25 PF13481.6 ADV21139.1 - 0.021 14.4 0.3 0.16 11.6 0.0 2.6 3 1 0 3 3 3 0 AAA domain AAA_24 PF13479.6 ADV21139.1 - 0.036 13.8 0.0 0.073 12.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 ADV21139.1 - 0.036 14.3 0.0 0.16 12.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 ADV21139.1 - 0.047 13.4 0.0 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain RNA_helicase PF00910.22 ADV21139.1 - 0.05 14.0 0.0 0.13 12.6 0.0 1.7 1 0 0 1 1 1 0 RNA helicase KAP_NTPase PF07693.14 ADV21139.1 - 0.066 12.4 0.0 0.098 11.9 0.0 1.2 1 0 0 1 1 1 0 KAP family P-loop domain ATPase PF06745.13 ADV21139.1 - 0.082 12.2 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 KaiC AAA_33 PF13671.6 ADV21139.1 - 0.094 12.9 0.0 0.17 12.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 ADV21139.1 - 0.1 11.7 0.0 0.17 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_11 PF13086.6 ADV21139.1 - 0.11 12.3 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 ADV21139.1 - 0.12 12.9 0.0 0.31 11.6 0.0 1.7 2 0 0 2 2 1 0 ABC transporter AAA_23 PF13476.6 ADV21139.1 - 0.13 12.7 0.0 0.24 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 ADV21139.1 - 0.16 12.0 0.0 0.37 10.8 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RuvB_N PF05496.12 ADV21139.1 - 0.16 11.7 0.0 0.3 10.8 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Rad17 PF03215.15 ADV21139.1 - 0.17 11.8 0.0 2.7 7.9 0.0 2.2 1 1 1 2 2 2 0 Rad17 P-loop domain FAD_binding_3 PF01494.19 ADV21140.1 - 1.1e-15 57.8 0.0 3.8e-15 56.0 0.0 1.8 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 ADV21140.1 - 6.5e-06 26.0 0.0 0.00081 19.1 0.0 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Trp_halogenase PF04820.14 ADV21140.1 - 1.9e-05 23.7 0.0 0.012 14.5 0.0 2.9 2 1 0 2 2 2 2 Tryptophan halogenase NAD_binding_8 PF13450.6 ADV21140.1 - 3.7e-05 23.9 0.0 9.5e-05 22.6 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain SE PF08491.10 ADV21140.1 - 0.0025 16.9 0.0 0.56 9.2 0.0 2.4 2 0 0 2 2 2 2 Squalene epoxidase Pyr_redox_2 PF07992.14 ADV21140.1 - 0.012 14.9 0.0 0.23 10.6 0.0 2.2 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ADV21140.1 - 0.013 16.0 0.1 0.16 12.5 0.0 2.8 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Glu_dehyd_C PF16912.5 ADV21140.1 - 0.019 14.4 0.0 0.057 12.9 0.0 1.7 2 0 0 2 2 2 0 Glucose dehydrogenase C-terminus ApbA PF02558.16 ADV21140.1 - 0.047 13.3 0.0 0.15 11.7 0.0 1.8 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA HI0933_like PF03486.14 ADV21140.1 - 0.062 12.0 0.0 0.22 10.2 0.0 1.8 2 0 0 2 2 2 0 HI0933-like protein NAD_binding_7 PF13241.6 ADV21140.1 - 0.12 12.8 0.0 0.25 11.8 0.0 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding Pyr_redox_3 PF13738.6 ADV21140.1 - 0.2 10.9 0.0 7.3 5.7 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Formyl_trans_N PF00551.19 ADV21141.1 - 1.9e-41 141.8 0.0 5.3e-22 78.4 0.1 2.1 2 0 0 2 2 2 2 Formyl transferase Spike_torovirin PF17072.5 ADV21142.1 - 0.065 10.4 0.1 0.077 10.1 0.1 1.0 1 0 0 1 1 1 0 Torovirinae spike glycoprotein HAD_2 PF13419.6 ADV21143.1 - 4.9e-10 39.8 0.0 1.3e-09 38.3 0.0 1.7 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ADV21143.1 - 8.5e-07 29.5 0.0 1e-06 29.2 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ADV21143.1 - 0.00013 22.0 0.0 0.0031 17.5 0.0 2.6 2 1 0 2 2 2 1 HAD-hyrolase-like HAD PF12710.7 ADV21143.1 - 0.14 12.5 0.0 0.26 11.7 0.0 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Thioredoxin PF00085.20 ADV21144.1 - 7.4e-28 96.6 0.3 8.6e-28 96.4 0.3 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 ADV21144.1 - 1e-07 32.3 0.6 1.4e-06 28.7 0.6 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 ADV21144.1 - 7.4e-07 29.4 0.0 9.7e-07 29.0 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_9 PF14595.6 ADV21144.1 - 1.5e-05 24.7 0.1 1.6e-05 24.7 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin AhpC-TSA PF00578.21 ADV21144.1 - 2.6e-05 24.1 0.1 2.9e-05 24.0 0.1 1.1 1 0 0 1 1 1 1 AhpC/TSA family Glutaredoxin PF00462.24 ADV21144.1 - 0.014 15.6 0.1 0.023 14.9 0.1 1.4 1 0 0 1 1 1 0 Glutaredoxin Redoxin PF08534.10 ADV21144.1 - 0.024 14.4 0.8 0.077 12.7 0.4 1.8 1 1 1 2 2 2 0 Redoxin OST3_OST6 PF04756.13 ADV21144.1 - 0.064 12.6 0.0 0.08 12.3 0.0 1.1 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family Phosducin PF02114.16 ADV21144.1 - 0.11 11.5 0.0 0.11 11.4 0.0 1.1 1 0 0 1 1 1 0 Phosducin Complex1_LYR PF05347.15 ADV21145.1 - 5.4e-06 26.4 0.8 7.3e-06 25.9 0.1 1.6 2 0 0 2 2 2 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 ADV21145.1 - 0.00012 22.8 0.7 0.0005 20.8 0.7 2.1 1 1 0 1 1 1 1 Complex1_LYR-like Pro_CA PF00484.19 ADV21146.1 - 1.2e-34 119.9 0.0 1.5e-34 119.6 0.0 1.1 1 0 0 1 1 1 1 Carbonic anhydrase NOA36 PF06524.12 ADV21147.1 - 0.1 11.9 3.7 0.15 11.4 3.7 1.2 1 0 0 1 1 1 0 NOA36 protein FYDLN_acid PF09538.10 ADV21147.1 - 0.61 10.8 6.6 1.7 9.4 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) Sec2p PF06428.11 ADV21148.1 - 6.2e-10 38.9 9.9 1.4e-09 37.8 9.9 1.6 1 1 0 1 1 1 1 GDP/GTP exchange factor Sec2p FAM76 PF16046.5 ADV21148.1 - 0.0004 19.8 0.4 0.00052 19.5 0.4 1.1 1 0 0 1 1 1 1 FAM76 protein ATG16 PF08614.11 ADV21148.1 - 0.0013 19.0 6.5 0.0024 18.1 6.5 1.4 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Uso1_p115_C PF04871.13 ADV21148.1 - 0.0018 18.6 7.0 0.0033 17.8 7.0 1.5 1 0 0 1 1 1 1 Uso1 / p115 like vesicle tethering protein, C terminal region DUF1640 PF07798.11 ADV21148.1 - 0.0023 18.0 1.4 0.0032 17.5 1.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) Rab5-bind PF09311.11 ADV21148.1 - 0.0027 17.2 2.9 0.0038 16.7 2.9 1.1 1 0 0 1 1 1 1 Rabaptin-like protein DUF4349 PF14257.6 ADV21148.1 - 0.0033 16.9 3.0 0.0047 16.4 3.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4349) Tmemb_cc2 PF10267.9 ADV21148.1 - 0.0045 16.2 0.3 0.0061 15.8 0.3 1.1 1 0 0 1 1 1 1 Predicted transmembrane and coiled-coil 2 protein Phage_GPO PF05929.11 ADV21148.1 - 0.0091 15.7 2.7 0.013 15.2 2.7 1.1 1 0 0 1 1 1 1 Phage capsid scaffolding protein (GPO) serine peptidase Golgin_A5 PF09787.9 ADV21148.1 - 0.0094 15.5 1.4 0.013 15.0 1.4 1.1 1 0 0 1 1 1 1 Golgin subfamily A member 5 ZapB PF06005.12 ADV21148.1 - 0.018 15.5 11.6 0.091 13.2 11.6 1.9 1 1 0 1 1 1 0 Cell division protein ZapB CENP-H PF05837.12 ADV21148.1 - 0.019 15.4 5.8 0.031 14.7 5.8 1.3 1 0 0 1 1 1 0 Centromere protein H (CENP-H) IFT57 PF10498.9 ADV21148.1 - 0.024 13.6 1.1 0.037 13.0 1.1 1.2 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 DUF1664 PF07889.12 ADV21148.1 - 0.026 14.6 1.1 0.044 13.8 1.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) FapA PF03961.13 ADV21148.1 - 0.038 12.6 0.6 0.049 12.2 0.6 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A SKA2 PF16740.5 ADV21148.1 - 0.038 13.8 1.5 0.075 12.8 1.5 1.5 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 2 DivIC PF04977.15 ADV21148.1 - 0.039 13.7 6.2 0.44 10.3 0.2 2.4 1 1 1 2 2 2 0 Septum formation initiator FUSC PF04632.12 ADV21148.1 - 0.055 12.0 1.6 0.068 11.7 1.6 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Spc7 PF08317.11 ADV21148.1 - 0.065 12.1 6.2 0.086 11.7 6.2 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein FlaC_arch PF05377.11 ADV21148.1 - 0.075 13.4 5.1 0.75 10.2 0.3 2.4 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Spectrin PF00435.21 ADV21148.1 - 0.1 13.1 3.4 0.16 12.5 3.0 1.5 2 0 0 2 2 1 0 Spectrin repeat YabA PF06156.13 ADV21148.1 - 0.11 13.1 4.5 0.31 11.7 4.4 1.7 1 1 1 2 2 2 0 Initiation control protein YabA Snapin_Pallidin PF14712.6 ADV21148.1 - 0.14 12.6 2.2 15 6.1 0.6 2.3 1 1 1 2 2 2 0 Snapin/Pallidin Macoilin PF09726.9 ADV21148.1 - 0.16 10.5 3.5 0.21 10.1 3.5 1.1 1 0 0 1 1 1 0 Macoilin family DUF745 PF05335.13 ADV21148.1 - 0.33 10.7 6.9 0.46 10.2 6.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF745) PEHE PF15275.6 ADV21148.1 - 0.56 10.8 4.9 1.1 9.8 4.9 1.6 1 1 0 1 1 1 0 PEHE domain APG6_N PF17675.1 ADV21148.1 - 2.1 8.9 12.3 27 5.3 12.3 2.1 1 1 0 1 1 1 0 Apg6 coiled-coil region Cep57_CLD_2 PF14197.6 ADV21148.1 - 3.6 7.7 12.4 0.077 13.1 1.6 2.5 1 1 1 2 2 2 0 Centrosome localisation domain of PPC89 SET PF00856.28 ADV21149.1 - 9.2e-11 42.4 0.0 2.3e-09 37.9 0.0 2.4 1 1 0 1 1 1 1 SET domain dCMP_cyt_deam_1 PF00383.23 ADV21149.1 - 9.8e-05 22.2 0.2 0.00021 21.1 0.2 1.6 1 1 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 ADV21149.1 - 0.00073 19.3 0.0 0.0033 17.2 0.0 1.9 2 0 0 2 2 2 1 MafB19-like deaminase DAO PF01266.24 ADV21150.1 - 6e-52 177.4 0.0 7.8e-52 177.0 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO_C PF16901.5 ADV21150.1 - 5.2e-42 142.7 0.1 1e-41 141.7 0.1 1.5 1 0 0 1 1 1 1 C-terminal domain of alpha-glycerophosphate oxidase FAD_binding_2 PF00890.24 ADV21150.1 - 7.6e-06 25.3 0.6 0.00071 18.8 0.1 2.2 2 0 0 2 2 2 2 FAD binding domain FAD_oxidored PF12831.7 ADV21150.1 - 0.00036 20.0 0.5 0.0022 17.4 0.1 2.3 3 0 0 3 3 3 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ADV21150.1 - 0.0028 16.9 0.0 0.0056 16.0 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 ADV21150.1 - 0.0053 16.1 0.0 0.48 9.6 0.0 2.4 2 0 0 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.6 ADV21150.1 - 0.0076 16.5 0.1 0.029 14.6 0.2 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DUF1932 PF09130.11 ADV21150.1 - 0.099 12.6 0.1 13 5.8 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1932) Pyr_redox_3 PF13738.6 ADV21150.1 - 0.1 11.8 0.0 0.29 10.4 0.0 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 ADV21150.1 - 0.16 11.0 0.1 4.1 6.4 0.0 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A Ras PF00071.22 ADV21151.1 - 1.1e-64 216.9 0.0 1.3e-64 216.7 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ADV21151.1 - 2.6e-34 118.0 0.0 3.7e-34 117.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ADV21151.1 - 4.5e-14 52.3 0.0 6e-14 51.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ADV21151.1 - 4.1e-05 23.6 0.0 0.00013 22.0 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ADV21151.1 - 7.9e-05 22.1 0.0 9.5e-05 21.8 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 ADV21151.1 - 0.0001 21.9 0.0 0.00034 20.2 0.0 1.8 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ADV21151.1 - 0.00013 22.0 0.0 0.29 11.0 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 ADV21151.1 - 0.0024 17.4 0.0 0.019 14.5 0.0 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B SRPRB PF09439.10 ADV21151.1 - 0.014 14.8 0.0 0.017 14.6 0.0 1.1 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_16 PF13191.6 ADV21151.1 - 0.031 14.6 0.0 0.049 14.0 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain MCM PF00493.23 ADV21151.1 - 0.038 13.1 0.0 0.23 10.5 0.0 1.9 2 0 0 2 2 2 0 MCM P-loop domain Septin PF00735.18 ADV21151.1 - 0.044 13.1 0.0 0.072 12.4 0.0 1.3 1 0 0 1 1 1 0 Septin AAA_29 PF13555.6 ADV21151.1 - 0.048 13.4 0.0 0.12 12.1 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 ADV21151.1 - 0.12 12.9 0.0 0.22 12.0 0.0 1.4 1 1 0 1 1 1 0 ABC transporter NACHT PF05729.12 ADV21151.1 - 0.16 11.9 0.1 0.44 10.4 0.0 1.7 2 1 0 2 2 2 0 NACHT domain STIMATE PF12400.8 ADV21152.1 - 4.6e-32 111.2 8.7 7.2e-32 110.6 8.7 1.3 1 0 0 1 1 1 1 STIMATE family Pkinase PF00069.25 ADV21153.1 - 6.2e-27 94.6 0.0 6.6e-25 88.0 0.0 2.9 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV21153.1 - 1.8e-15 56.9 0.0 2.9e-14 53.0 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 ADV21153.1 - 0.043 13.1 0.0 0.12 11.6 0.0 1.6 2 0 0 2 2 2 0 Kinase-like Methyltransf_28 PF02636.17 ADV21154.1 - 1.3e-33 116.8 0.0 1.9e-33 116.2 0.0 1.2 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase RrnaAD PF00398.20 ADV21154.1 - 0.045 12.8 0.0 0.089 11.8 0.0 1.4 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Lyase_1 PF00206.20 ADV21155.1 - 3.6e-99 332.1 0.0 5.4e-99 331.5 0.0 1.3 1 0 0 1 1 1 1 Lyase ASL_C2 PF14698.6 ADV21155.1 - 5e-24 84.8 0.0 1.1e-23 83.7 0.0 1.6 1 0 0 1 1 1 1 Argininosuccinate lyase C-terminal NDUF_B7 PF05676.13 ADV21157.1 - 1.1e-32 111.5 3.1 1.4e-32 111.2 3.1 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Cmc1 PF08583.10 ADV21157.1 - 0.035 14.1 2.8 0.055 13.5 2.8 1.2 1 0 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like RNase_P_Rpp14 PF01900.19 ADV21158.1 - 2.2e-27 95.3 0.0 3e-27 94.9 0.0 1.2 1 0 0 1 1 1 1 Rpp14/Pop5 family Dak1 PF02733.17 ADV21158.1 - 0.03 13.2 0.0 0.04 12.8 0.0 1.2 1 0 0 1 1 1 0 Dak1 domain Ribosomal_S17 PF00366.20 ADV21159.1 - 5.8e-20 71.2 0.8 8.4e-20 70.7 0.8 1.3 1 0 0 1 1 1 1 Ribosomal protein S17 BPS PF08947.10 ADV21159.1 - 0.04 13.7 0.0 0.076 12.9 0.0 1.4 1 0 0 1 1 1 0 BPS (Between PH and SH2) Psb28 PF03912.14 ADV21159.1 - 0.097 13.0 0.0 0.17 12.2 0.0 1.3 1 0 0 1 1 1 0 Psb28 protein p450 PF00067.22 ADV21160.1 - 2.1e-50 171.8 0.0 3.1e-50 171.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Lactamase_B_2 PF12706.7 ADV21161.1 - 6.3e-33 114.0 2.0 8.8e-33 113.5 2.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 ADV21161.1 - 2.1e-13 50.5 0.1 3.2e-13 49.9 0.1 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 ADV21161.1 - 0.041 13.9 0.2 0.13 12.2 0.1 2.0 2 0 0 2 2 2 0 Metallo-beta-lactamase superfamily Thymidylate_kin PF02223.17 ADV21164.1 - 2.9e-45 154.2 0.0 3.3e-45 154.0 0.0 1.0 1 0 0 1 1 1 1 Thymidylate kinase SF-assemblin PF06705.11 ADV21164.1 - 0.0016 17.8 0.1 0.0032 16.9 0.0 1.4 2 0 0 2 2 2 1 SF-assemblin/beta giardin Transglycosylas PF06737.14 ADV21164.1 - 0.037 14.7 0.1 0.08 13.6 0.1 1.6 1 0 0 1 1 1 0 Transglycosylase-like domain AAA_33 PF13671.6 ADV21164.1 - 0.066 13.4 0.0 0.33 11.1 0.0 2.1 1 1 0 1 1 1 0 AAA domain KTI12 PF08433.10 ADV21164.1 - 0.092 12.2 0.0 0.19 11.2 0.0 1.5 1 0 0 1 1 1 0 Chromatin associated protein KTI12 DUF962 PF06127.11 ADV21165.1 - 7e-25 86.9 0.0 1.2e-24 86.2 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF962) PLDc_2 PF13091.6 ADV21166.1 - 5.3e-13 49.0 0.0 2.1e-05 24.4 0.0 2.4 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 ADV21166.1 - 1.5e-07 31.3 0.1 0.00088 19.4 0.0 2.6 2 0 0 2 2 2 2 Phospholipase D Active site motif UL42 PF17638.2 ADV21166.1 - 1.6 8.8 7.7 0.11 12.5 1.0 2.4 3 0 0 3 3 3 0 HCMV UL42 RRM_1 PF00076.22 ADV21167.1 - 8.5e-05 22.3 0.0 0.00022 21.0 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MRP-L46 PF11788.8 ADV21168.1 - 8.8e-12 45.8 0.1 1.6e-11 45.0 0.1 1.6 1 1 0 1 1 1 1 39S mitochondrial ribosomal protein L46 Pyr_redox_2 PF07992.14 ADV21169.1 - 4.6e-24 85.2 0.0 1e-22 80.8 0.0 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ADV21169.1 - 3.2e-08 34.0 0.1 8.1e-06 26.3 0.0 3.2 2 1 1 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 ADV21169.1 - 0.0042 16.0 0.1 0.78 8.5 0.0 2.5 3 0 0 3 3 3 2 Tryptophan halogenase Lycopene_cycl PF05834.12 ADV21169.1 - 0.0055 15.8 0.0 0.13 11.3 0.0 2.2 2 0 0 2 2 2 1 Lycopene cyclase protein AlaDh_PNT_C PF01262.21 ADV21169.1 - 0.0098 15.2 0.0 0.6 9.4 0.0 2.4 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_3 PF13738.6 ADV21169.1 - 0.084 12.1 0.0 0.15 11.3 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 ADV21169.1 - 0.13 12.6 0.0 3.6 7.9 0.0 2.4 2 0 0 2 2 2 0 TrkA-N domain K_oxygenase PF13434.6 ADV21169.1 - 0.28 10.3 0.0 0.47 9.5 0.0 1.3 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) MFS_1 PF07690.16 ADV21171.1 - 1.1e-16 60.7 54.5 8.5e-09 34.8 38.1 3.3 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 ADV21171.1 - 4.9e-10 38.5 23.9 7e-10 38.0 23.9 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 ADV21171.1 - 3.1e-07 29.6 12.0 3.1e-07 29.6 12.0 2.6 3 0 0 3 3 3 2 Sugar (and other) transporter Glyco_transf_28 PF03033.20 ADV21172.1 - 5e-29 101.1 0.0 9.6e-29 100.2 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain GRAM PF02893.20 ADV21172.1 - 1.6e-26 92.4 4.4 7.7e-13 48.3 0.2 3.3 3 0 0 3 3 3 3 GRAM domain PH PF00169.29 ADV21172.1 - 2.5e-12 47.2 3.0 3.9e-11 43.4 0.4 2.9 3 0 0 3 3 3 1 PH domain UDPGT PF00201.18 ADV21172.1 - 1.6e-07 30.5 0.0 3.1e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase PH_6 PF15406.6 ADV21172.1 - 1.1e-05 25.7 0.2 9.7e-05 22.6 0.0 2.5 2 0 0 2 2 2 1 Pleckstrin homology domain PH_3 PF14593.6 ADV21172.1 - 9.3e-05 22.5 0.0 0.00018 21.5 0.0 1.5 1 0 0 1 1 1 1 PH domain PH_13 PF16652.5 ADV21172.1 - 0.076 12.8 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain PH_11 PF15413.6 ADV21172.1 - 0.26 11.7 2.4 8.6 6.8 2.4 2.6 1 1 0 1 1 1 0 Pleckstrin homology domain Asp PF00026.23 ADV21173.1 - 3.6e-60 204.0 2.3 3.6e-60 204.0 2.3 2.5 2 1 0 2 2 2 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 ADV21173.1 - 1e-12 48.7 0.3 1.8e-10 41.4 0.3 2.5 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal ERG4_ERG24 PF01222.17 ADV21174.1 - 1.5e-128 429.2 21.2 1.7e-128 429.0 21.2 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 ADV21174.1 - 0.00012 21.6 1.6 0.0003 20.4 1.6 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) PEMT PF04191.13 ADV21174.1 - 0.0066 16.8 0.9 0.065 13.6 0.0 3.1 3 0 0 3 3 3 1 Phospholipid methyltransferase ICMT PF04140.14 ADV21174.1 - 0.011 16.2 0.3 0.064 13.7 0.0 2.3 2 0 0 2 2 2 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PRMT5_TIM PF17285.2 ADV21175.1 - 3e-99 331.4 0.0 4e-99 331.0 0.0 1.2 1 0 0 1 1 1 1 PRMT5 TIM barrel domain PRMT5 PF05185.16 ADV21175.1 - 3.7e-64 215.7 0.0 6.2e-64 215.0 0.0 1.4 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase PRMT5_C PF17286.2 ADV21175.1 - 6e-61 205.4 0.0 9.1e-61 204.8 0.0 1.3 1 0 0 1 1 1 1 PRMT5 oligomerisation domain ubiquitin PF00240.23 ADV21176.1 - 4.7e-19 67.9 0.0 5.3e-19 67.7 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ADV21176.1 - 4.8e-10 39.1 0.0 5.1e-10 39.1 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 ADV21176.1 - 0.00019 21.8 0.0 0.00094 19.6 0.0 1.9 1 1 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 ADV21176.1 - 0.044 13.7 0.0 0.054 13.4 0.0 1.1 1 0 0 1 1 1 0 TANK binding kinase 1 ubiquitin-like domain NAT PF04768.13 ADV21177.1 - 5.2e-33 114.1 0.2 1.1e-19 70.7 0.0 2.2 2 0 0 2 2 2 2 NAT, N-acetyltransferase, of N-acetylglutamate synthase DEAD PF00270.29 ADV21179.1 - 2.4e-22 79.6 0.0 9.6e-22 77.6 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase RQC PF09382.10 ADV21179.1 - 4.3e-20 71.6 0.0 8.1e-19 67.5 0.0 2.7 2 0 0 2 2 2 1 RQC domain HRDC PF00570.23 ADV21179.1 - 3.5e-11 42.9 0.1 8.8e-11 41.6 0.1 1.8 1 0 0 1 1 1 1 HRDC domain RecQ_Zn_bind PF16124.5 ADV21179.1 - 5.8e-11 43.0 4.5 5.8e-11 43.0 4.5 2.3 2 0 0 2 2 2 1 RecQ zinc-binding Helicase_C PF00271.31 ADV21179.1 - 2.3e-09 37.6 0.1 2.8e-07 30.8 0.1 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ADV21179.1 - 0.00042 20.4 0.0 0.0012 18.9 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Pex19 PF04614.12 ADV21179.1 - 7.1 6.3 8.7 0.52 10.0 2.7 1.9 1 1 1 2 2 2 0 Pex19 protein family Atg14 PF10186.9 ADV21180.1 - 2.4 7.2 7.7 3.5 6.6 7.7 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 GCV_T PF01571.21 ADV21181.1 - 3.1e-83 279.1 0.0 3.9e-83 278.7 0.0 1.1 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.11 ADV21181.1 - 5.3e-20 71.1 0.1 1.5e-19 69.7 0.1 1.7 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain SoxG PF04268.12 ADV21181.1 - 0.01 16.0 0.1 0.099 12.8 0.0 2.5 3 0 0 3 3 3 0 Sarcosine oxidase, gamma subunit family Nic96 PF04097.14 ADV21182.1 - 5.1e-180 600.0 0.1 7.6e-180 599.4 0.1 1.2 1 0 0 1 1 1 1 Nup93/Nic96 DAO PF01266.24 ADV21183.1 - 4.9e-54 184.2 0.0 9e-54 183.4 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO_C PF16901.5 ADV21183.1 - 1.1e-43 148.1 0.1 2.8e-43 146.8 0.0 1.8 2 0 0 2 2 2 1 C-terminal domain of alpha-glycerophosphate oxidase FAD_binding_2 PF00890.24 ADV21183.1 - 1.8e-08 33.9 0.3 2.3e-05 23.7 0.1 2.7 3 0 0 3 3 3 2 FAD binding domain EF-hand_7 PF13499.6 ADV21183.1 - 4.7e-08 33.4 0.9 1.4e-07 31.9 0.9 1.9 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 ADV21183.1 - 1.9e-05 23.9 1.0 0.014 14.9 0.1 2.7 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 ADV21183.1 - 5.8e-05 22.9 0.3 0.00048 19.9 0.2 2.6 2 1 1 3 3 3 1 EF-hand domain pair FAD_oxidored PF12831.7 ADV21183.1 - 0.00014 21.4 0.2 0.00042 19.8 0.1 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase EF-hand_6 PF13405.6 ADV21183.1 - 0.00022 20.9 1.9 0.0029 17.4 0.2 2.7 2 0 0 2 2 2 1 EF-hand domain Pyr_redox_2 PF07992.14 ADV21183.1 - 0.0005 19.4 0.0 0.0014 18.0 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ADV21183.1 - 0.0029 17.8 0.2 0.0099 16.1 0.2 1.9 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 ADV21183.1 - 0.018 14.3 0.0 0.19 11.0 0.0 2.3 3 0 0 3 3 3 0 FAD binding domain HI0933_like PF03486.14 ADV21183.1 - 0.11 11.2 0.1 0.21 10.2 0.1 1.4 1 0 0 1 1 1 0 HI0933-like protein Pyr_redox PF00070.27 ADV21183.1 - 0.11 13.1 0.0 0.43 11.2 0.1 2.0 2 0 0 2 2 1 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 ADV21183.1 - 0.19 10.8 0.1 0.67 9.0 0.0 1.8 2 0 0 2 2 2 0 Glucose inhibited division protein A OTCace PF00185.24 ADV21184.1 - 2.5e-49 167.4 0.0 3.6e-49 166.8 0.0 1.2 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain OTCace_N PF02729.21 ADV21184.1 - 9.5e-47 158.7 0.0 1.5e-46 158.0 0.0 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain Ribosomal_S14 PF00253.21 ADV21185.1 - 8.6e-14 51.0 1.9 9.5e-14 50.9 1.9 1.1 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e PUF PF00806.19 ADV21186.1 - 8.5e-63 204.7 4.7 1.3e-09 37.2 0.0 8.3 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat Cation_efflux PF01545.21 ADV21187.1 - 4.7e-47 160.3 11.7 4.1e-46 157.2 11.7 2.0 1 1 0 1 1 1 1 Cation efflux family zf-HIT PF04438.16 ADV21188.1 - 4.2e-10 39.3 12.2 7.6e-10 38.5 12.2 1.4 1 0 0 1 1 1 1 HIT zinc finger Arrestin_C PF02752.22 ADV21189.1 - 0.00018 22.0 0.3 0.0014 19.1 0.2 2.5 2 1 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Dak1 PF02733.17 ADV21190.1 - 5.2e-109 363.9 1.0 6.9e-109 363.5 1.0 1.2 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.17 ADV21190.1 - 8.6e-41 139.7 1.3 1.5e-40 139.0 1.3 1.4 1 0 0 1 1 1 1 DAK2 domain Synuclein PF01387.17 ADV21190.1 - 0.26 11.5 2.5 0.26 11.5 0.6 1.9 2 0 0 2 2 2 0 Synuclein DAHP_synth_2 PF01474.16 ADV21191.1 - 4.5e-196 651.6 0.0 5.2e-196 651.4 0.0 1.0 1 0 0 1 1 1 1 Class-II DAHP synthetase family DHO_dh PF01180.21 ADV21192.1 - 2.3e-90 302.8 0.0 2.9e-90 302.5 0.0 1.1 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase FMN_dh PF01070.18 ADV21192.1 - 0.01 14.9 1.3 0.072 12.1 0.4 2.6 3 1 0 3 3 3 0 FMN-dependent dehydrogenase NMO PF03060.15 ADV21192.1 - 0.017 14.5 0.1 0.034 13.5 0.1 1.4 1 0 0 1 1 1 0 Nitronate monooxygenase DUF1179 PF06678.11 ADV21192.1 - 0.32 11.0 1.2 12 5.9 0.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1179) DUF3767 PF12597.8 ADV21193.1 - 5.4e-07 29.4 0.0 7e-06 25.8 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF3767) Glyco_transf_8 PF01501.20 ADV21194.1 - 1.3e-11 44.6 0.0 2.1e-11 43.9 0.0 1.4 1 1 0 1 1 1 1 Glycosyl transferase family 8 Glyco_transf_24 PF18404.1 ADV21194.1 - 0.061 12.7 0.0 0.094 12.1 0.0 1.2 1 0 0 1 1 1 0 Glucosyltransferase 24 Mannosyl_trans3 PF11051.8 ADV21194.1 - 0.096 12.0 0.7 0.15 11.4 0.7 1.2 1 0 0 1 1 1 0 Mannosyltransferase putative bZIP_1 PF00170.21 ADV21195.1 - 0.00033 20.7 2.6 0.00033 20.7 2.6 1.8 2 0 0 2 2 2 1 bZIP transcription factor TSC22 PF01166.18 ADV21195.1 - 0.036 14.4 0.3 0.083 13.2 0.3 1.6 1 0 0 1 1 1 0 TSC-22/dip/bun family ABC_tran_CTD PF16326.5 ADV21195.1 - 0.055 13.7 0.3 0.12 12.6 0.3 1.5 1 0 0 1 1 1 0 ABC transporter C-terminal domain SIKE PF05769.11 ADV21195.1 - 0.14 12.1 0.6 0.21 11.5 0.6 1.2 1 0 0 1 1 1 0 SIKE family Metal_resist PF13801.6 ADV21195.1 - 2.5 8.3 10.5 3.3 7.9 3.7 2.6 3 0 0 3 3 3 0 Heavy-metal resistance Pterin_bind PF00809.22 ADV21196.1 - 2.9e-64 217.1 0.0 4.1e-64 216.6 0.0 1.2 1 0 0 1 1 1 1 Pterin binding enzyme HPPK PF01288.20 ADV21196.1 - 5.9e-33 113.7 0.0 1.1e-32 112.8 0.0 1.5 1 0 0 1 1 1 1 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) FolB PF02152.18 ADV21196.1 - 1.1e-18 67.8 0.0 2.9e-16 60.0 0.0 2.9 3 0 0 3 3 3 2 Dihydroneopterin aldolase LRR_8 PF13855.6 ADV21197.1 - 2.7e-14 52.7 21.9 7.4e-08 32.0 3.3 4.9 2 2 2 4 4 4 3 Leucine rich repeat Abhydrolase_3 PF07859.13 ADV21197.1 - 4.9e-13 49.4 0.0 6.2e-12 45.8 0.0 2.3 2 0 0 2 2 2 1 alpha/beta hydrolase fold LRR_4 PF12799.7 ADV21197.1 - 9.6e-13 48.1 24.9 4.8e-06 26.8 5.6 4.5 2 2 2 4 4 4 3 Leucine Rich repeats (2 copies) Peptidase_S9 PF00326.21 ADV21197.1 - 5.8e-05 22.7 0.1 0.026 14.0 0.1 2.3 2 0 0 2 2 2 2 Prolyl oligopeptidase family LRR_1 PF00560.33 ADV21197.1 - 0.0011 19.2 17.7 2 9.3 0.1 6.4 6 0 0 6 6 6 2 Leucine Rich Repeat DLH PF01738.18 ADV21197.1 - 0.0011 18.6 0.0 0.0024 17.5 0.0 1.4 1 0 0 1 1 1 1 Dienelactone hydrolase family LRR_6 PF13516.6 ADV21197.1 - 0.0015 18.4 21.3 0.36 11.0 0.0 6.1 6 0 0 6 6 6 2 Leucine Rich repeat COesterase PF00135.28 ADV21197.1 - 0.0069 15.3 0.0 0.013 14.4 0.0 1.3 1 0 0 1 1 1 1 Carboxylesterase family Esterase_phd PF10503.9 ADV21197.1 - 0.019 14.4 0.0 0.04 13.4 0.0 1.5 1 0 0 1 1 1 0 Esterase PHB depolymerase Esterase PF00756.20 ADV21197.1 - 0.032 13.9 0.4 0.44 10.1 0.1 2.7 3 1 0 3 3 3 0 Putative esterase Abhydrolase_2 PF02230.16 ADV21197.1 - 0.091 12.6 0.0 0.72 9.6 0.0 2.0 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase SET PF00856.28 ADV21198.1 - 0.0002 21.8 0.0 0.00037 20.9 0.0 1.5 1 0 0 1 1 1 1 SET domain Rubis-subs-bind PF09273.11 ADV21198.1 - 0.045 14.4 0.3 0.088 13.5 0.3 1.5 1 0 0 1 1 1 0 Rubisco LSMT substrate-binding QRPTase_C PF01729.19 ADV21199.1 - 1e-48 165.3 0.0 1.2e-48 165.0 0.0 1.1 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain QRPTase_N PF02749.16 ADV21199.1 - 8.2e-19 67.5 0.1 3.9e-18 65.3 0.0 2.1 3 0 0 3 3 3 1 Quinolinate phosphoribosyl transferase, N-terminal domain SBD_N PF07005.11 ADV21199.1 - 0.12 12.1 0.1 0.3 10.8 0.1 1.7 1 0 0 1 1 1 0 Sugar-binding N-terminal domain Fungal_trans PF04082.18 ADV21200.1 - 1.7e-11 43.7 0.1 1.2e-10 40.9 0.0 2.1 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ADV21200.1 - 1.1e-08 35.1 7.5 1.8e-08 34.4 7.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain His_Phos_1 PF00300.22 ADV21201.1 - 4.6e-13 49.3 0.2 3.4e-11 43.2 0.1 2.8 2 1 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) DNA_pol_A_exo1 PF01612.20 ADV21202.1 - 7.5e-44 149.5 0.0 1.3e-43 148.7 0.0 1.4 1 0 0 1 1 1 1 3'-5' exonuclease HRDC PF00570.23 ADV21202.1 - 5.7e-11 42.2 0.0 1.2e-10 41.2 0.0 1.6 1 0 0 1 1 1 1 HRDC domain AhpC-TSA PF00578.21 ADV21203.1 - 3.9e-30 104.3 0.0 4.8e-30 104.0 0.0 1.0 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 ADV21203.1 - 3.9e-18 65.6 0.0 4.3e-18 65.4 0.0 1.0 1 0 0 1 1 1 1 Redoxin Ribophorin_II PF05817.14 ADV21204.1 - 1.4e-12 47.0 0.0 1.8e-12 46.7 0.0 1.1 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit Ribophorin II DUF1435 PF07256.12 ADV21204.1 - 0.0033 17.5 4.2 0.0068 16.5 4.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1435) PIG-Y PF15159.6 ADV21204.1 - 0.62 11.0 3.0 0.86 10.6 2.0 1.8 1 1 1 2 2 2 0 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y TrkH PF02386.16 ADV21205.1 - 1.1e-120 403.5 18.3 2.6e-113 379.1 6.9 2.1 2 0 0 2 2 2 2 Cation transport protein NAD_kinase PF01513.21 ADV21206.1 - 1.1e-49 169.2 0.0 1.5e-49 168.7 0.0 1.1 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 ADV21206.1 - 0.093 12.3 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain Glyco_hydro_16 PF00722.21 ADV21207.1 - 0.0002 20.9 0.0 0.00048 19.7 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 PHP PF02811.19 ADV21208.1 - 1.2e-06 28.9 0.0 2.4e-06 28.0 0.0 1.5 1 1 0 1 1 1 1 PHP domain PI-PLC-X PF00388.19 ADV21210.1 - 3.6e-58 195.3 0.0 1.3e-57 193.4 0.0 2.0 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 ADV21210.1 - 3.6e-40 136.9 0.0 8.1e-40 135.8 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.30 ADV21210.1 - 6.1e-07 29.7 0.0 1.3e-06 28.6 0.0 1.5 1 0 0 1 1 1 1 C2 domain GDPD PF03009.17 ADV21210.1 - 0.00036 20.3 0.0 0.00058 19.7 0.0 1.3 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family DUF2591 PF10765.9 ADV21210.1 - 0.14 12.5 0.0 0.37 11.1 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2591) Mur_ligase_M PF08245.12 ADV21211.1 - 1.5e-06 28.4 0.0 1.6e-05 25.0 0.0 2.4 1 1 1 2 2 2 1 Mur ligase middle domain Mur_ligase_C PF02875.21 ADV21211.1 - 0.0055 16.9 0.0 0.046 14.0 0.0 2.4 2 1 0 2 2 2 1 Mur ligase family, glutamate ligase domain Mannosyl_trans2 PF04188.13 ADV21212.1 - 2.5e-47 162.2 11.8 4.2e-47 161.5 11.8 1.3 1 1 0 1 1 1 1 Mannosyltransferase (PIG-V) PMT_2 PF13231.6 ADV21212.1 - 0.005 17.1 9.7 0.024 14.8 9.7 2.3 1 1 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase zf-RING_2 PF13639.6 ADV21213.1 - 8.7e-10 38.8 13.6 6.2e-09 36.0 2.5 3.3 3 0 0 3 3 3 2 Ring finger domain zf-rbx1 PF12678.7 ADV21213.1 - 5.7e-08 32.9 11.5 1.6e-06 28.3 5.9 2.9 2 1 0 2 2 2 2 RING-H2 zinc finger domain zf-RING_11 PF17123.5 ADV21213.1 - 4.2e-07 29.6 6.6 0.002 17.8 0.0 3.4 3 0 0 3 3 3 2 RING-like zinc finger zf-C3HC4 PF00097.25 ADV21213.1 - 2.2e-06 27.4 5.3 5.1e-05 23.1 1.6 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ADV21213.1 - 6.5e-05 22.7 4.9 6.5e-05 22.7 4.9 2.8 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ADV21213.1 - 0.00069 19.6 6.8 0.034 14.2 3.3 2.9 2 1 0 2 2 2 1 RING-type zinc-finger Prok-RING_4 PF14447.6 ADV21213.1 - 0.0014 18.5 0.7 0.0014 18.5 0.7 2.2 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 Zn_ribbon_17 PF17120.5 ADV21213.1 - 0.005 16.4 2.0 0.005 16.4 2.0 2.3 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type zf-ANAPC11 PF12861.7 ADV21213.1 - 0.01 15.9 2.4 0.046 13.8 0.2 2.7 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zinc_ribbon_16 PF17034.5 ADV21213.1 - 0.012 15.8 0.2 0.026 14.7 0.2 1.5 1 0 0 1 1 1 0 Zinc-ribbon like family zf-C3HC4_3 PF13920.6 ADV21213.1 - 0.013 15.3 0.4 0.013 15.3 0.4 2.4 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ADV21213.1 - 0.05 13.6 14.2 0.076 13.0 4.5 2.9 2 2 0 2 2 2 0 zinc-RING finger domain zf-C3H2C3 PF17122.5 ADV21213.1 - 0.16 12.0 9.0 1.3 9.1 4.6 2.4 2 0 0 2 2 2 0 Zinc-finger zf-RING-like PF08746.11 ADV21213.1 - 0.23 11.8 11.0 0.63 10.4 2.8 2.8 3 0 0 3 3 3 0 RING-like domain zf-RING_4 PF14570.6 ADV21213.1 - 0.62 9.9 2.3 6.2 6.7 0.3 2.5 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain FANCL_C PF11793.8 ADV21213.1 - 0.89 9.8 6.6 0.54 10.5 0.5 3.0 4 0 0 4 4 3 0 FANCL C-terminal domain Zn_clus PF00172.18 ADV21214.1 - 8.6e-08 32.2 12.4 2e-07 31.0 12.4 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-H2C2_2 PF13465.6 ADV21214.1 - 1.3e-06 28.6 0.8 1.3e-06 28.6 0.8 2.3 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2 PF00096.26 ADV21214.1 - 0.0014 18.9 0.3 0.0014 18.9 0.3 2.5 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ADV21214.1 - 0.048 14.5 0.3 0.048 14.5 0.3 3.2 4 0 0 4 4 4 0 C2H2-type zinc finger PGP_phosphatase PF09419.10 ADV21215.1 - 2.7e-36 124.7 0.0 2.1e-32 112.0 0.0 2.2 2 0 0 2 2 2 2 Mitochondrial PGP phosphatase dCMP_cyt_deam_1 PF00383.23 ADV21216.1 - 2.5e-11 43.4 0.0 3.3e-11 42.9 0.0 1.1 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region dCMP_cyt_deam_2 PF08211.12 ADV21216.1 - 1.2e-05 25.5 1.0 0.0065 16.7 0.3 2.1 2 0 0 2 2 2 2 Cytidine and deoxycytidylate deaminase zinc-binding region LmjF365940-deam PF14421.6 ADV21216.1 - 0.029 14.0 2.1 0.97 9.0 0.1 2.1 1 1 1 2 2 2 0 A distinct subfamily of CDD/CDA-like deaminases Ras PF00071.22 ADV21217.1 - 7.4e-55 185.0 0.0 8.4e-55 184.8 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ADV21217.1 - 3.5e-22 78.9 0.0 5.2e-22 78.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ADV21217.1 - 4.4e-07 29.5 0.0 5.3e-07 29.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ADV21217.1 - 0.0024 17.4 0.0 0.011 15.3 0.0 1.8 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Glyco_hydro_72 PF03198.14 ADV21217.1 - 0.059 12.6 0.0 0.066 12.4 0.0 1.2 1 0 0 1 1 1 0 Glucanosyltransferase Vps16_C PF04840.12 ADV21217.1 - 0.14 11.2 0.0 0.18 10.8 0.0 1.1 1 0 0 1 1 1 0 Vps16, C-terminal region Sec7 PF01369.20 ADV21219.1 - 2.2e-63 213.3 0.0 3.7e-63 212.5 0.0 1.4 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 ADV21219.1 - 6e-16 58.8 0.2 7e-15 55.3 0.0 2.8 3 0 0 3 3 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal Pex14_N PF04695.13 ADV21219.1 - 9.4e-05 23.1 2.3 9.4e-05 23.1 2.3 2.5 3 0 0 3 3 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF3464 PF11947.8 ADV21219.1 - 0.0063 16.3 0.4 0.014 15.2 0.4 1.5 1 0 0 1 1 1 1 Photosynthesis affected mutant 68 DUF2722 PF10846.8 ADV21219.1 - 0.021 13.8 4.6 0.035 13.0 4.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Spt20 PF12090.8 ADV21219.1 - 0.028 14.0 5.3 0.067 12.8 5.3 1.6 1 0 0 1 1 1 0 Spt20 family CobT PF06213.12 ADV21219.1 - 0.033 13.6 8.8 0.064 12.6 8.8 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DDHD PF02862.17 ADV21219.1 - 0.04 14.1 0.1 0.089 12.9 0.1 1.5 1 0 0 1 1 1 0 DDHD domain Coilin_N PF15862.5 ADV21219.1 - 0.041 13.7 6.4 0.089 12.6 6.4 1.5 1 0 0 1 1 1 0 Coilin N-terminus Band_3_cyto PF07565.13 ADV21219.1 - 0.22 11.3 4.0 0.54 10.0 4.0 1.6 1 0 0 1 1 1 0 Band 3 cytoplasmic domain RICTOR_N PF14664.6 ADV21219.1 - 0.23 10.4 2.3 5 6.0 0.0 3.0 3 0 0 3 3 3 0 Rapamycin-insensitive companion of mTOR, N-term DUF913 PF06025.12 ADV21219.1 - 0.24 10.4 1.9 0.62 9.0 1.7 1.7 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) FancD2 PF14631.6 ADV21219.1 - 0.33 8.3 4.8 0.51 7.7 4.8 1.1 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease Presenilin PF01080.17 ADV21219.1 - 0.51 9.1 3.9 0.88 8.3 3.9 1.3 1 0 0 1 1 1 0 Presenilin Ufd2P_core PF10408.9 ADV21219.1 - 1.2 7.6 5.5 2 6.9 5.5 1.2 1 0 0 1 1 1 0 Ubiquitin elongating factor core V_ATPase_I PF01496.19 ADV21219.1 - 1.5 6.6 5.2 2.3 6.0 5.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Vfa1 PF08432.10 ADV21219.1 - 3.9 7.8 13.7 7.6 6.8 13.7 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 CLN3 PF02487.17 ADV21219.1 - 5.5 5.9 5.2 11 5.0 5.2 1.4 1 0 0 1 1 1 0 CLN3 protein Connexin PF00029.19 ADV21219.1 - 7 6.3 5.4 13 5.5 5.4 1.3 1 0 0 1 1 1 0 Connexin Rhodanese PF00581.20 ADV21220.1 - 1.3e-14 54.7 0.0 1.7e-14 54.2 0.0 1.2 1 0 0 1 1 1 1 Rhodanese-like domain RlmM_FDX PF18125.1 ADV21220.1 - 0.071 13.6 0.0 0.13 12.8 0.0 1.3 1 0 0 1 1 1 0 RlmM ferredoxin-like domain PhzC-PhzF PF02567.16 ADV21221.1 - 2.3e-36 125.8 0.3 2.7e-36 125.5 0.3 1.0 1 0 0 1 1 1 1 Phenazine biosynthesis-like protein Dynamin_N PF00350.23 ADV21222.1 - 8e-41 139.9 0.0 1.8e-40 138.8 0.0 1.6 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 ADV21222.1 - 1.4e-08 34.3 0.2 1.2e-06 27.9 0.2 3.1 1 1 0 1 1 1 1 Dynamin central region MMR_HSR1 PF01926.23 ADV21222.1 - 2.7e-05 24.2 0.0 0.00014 21.9 0.0 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase YtxH PF12732.7 ADV21222.1 - 0.014 15.9 1.4 0.15 12.6 0.1 3.0 2 0 0 2 2 2 0 YtxH-like protein AAA_21 PF13304.6 ADV21222.1 - 0.034 13.9 0.0 0.077 12.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system ApoLp-III PF07464.11 ADV21222.1 - 0.071 13.2 2.0 0.15 12.1 0.0 2.4 3 0 0 3 3 3 0 Apolipophorin-III precursor (apoLp-III) AAA_15 PF13175.6 ADV21222.1 - 0.19 11.4 0.0 0.19 11.4 0.0 2.7 4 0 0 4 4 4 0 AAA ATPase domain HMG_CoA_synt_N PF01154.17 ADV21223.1 - 1.7e-84 282.0 0.5 3.6e-84 281.0 0.1 1.7 2 0 0 2 2 2 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal HMG_CoA_synt_C PF08540.10 ADV21223.1 - 9.7e-81 271.4 0.0 1.4e-60 205.3 0.0 2.1 2 0 0 2 2 2 2 Hydroxymethylglutaryl-coenzyme A synthase C terminal ACP_syn_III_C PF08541.10 ADV21223.1 - 0.082 13.1 0.1 0.21 11.8 0.1 1.7 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ACP_syn_III PF08545.10 ADV21223.1 - 2.2 8.2 4.9 2.4 8.1 0.0 3.2 3 1 1 4 4 4 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III IPK PF03770.16 ADV21224.1 - 1.8e-50 171.5 0.0 3.4e-50 170.6 0.0 1.5 1 0 0 1 1 1 1 Inositol polyphosphate kinase COX6B PF02297.17 ADV21226.1 - 7e-24 83.9 0.3 8.6e-24 83.6 0.3 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb tRNA_m1G_MT PF01746.21 ADV21227.1 - 9.9e-24 84.1 0.0 1e-19 71.0 0.0 2.2 2 0 0 2 2 2 2 tRNA (Guanine-1)-methyltransferase OSK PF17182.4 ADV21227.1 - 0.21 10.8 0.0 0.32 10.2 0.0 1.2 1 0 0 1 1 1 0 OSK domain TPR_MLP1_2 PF07926.12 ADV21227.1 - 0.25 11.4 7.0 0.64 10.1 7.0 1.6 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein DUF1151 PF06625.11 ADV21227.1 - 0.58 10.1 7.8 1.4 8.9 7.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1151) DUF3824 PF12868.7 ADV21227.1 - 7.9 7.1 11.9 3.9 8.1 5.8 2.2 2 0 0 2 2 2 0 Domain of unknwon function (DUF3824) B-block_TFIIIC PF04182.12 ADV21228.1 - 8.1e-15 54.7 0.0 2.2e-14 53.4 0.0 1.8 1 0 0 1 1 1 1 B-block binding subunit of TFIIIC Sensor PF13796.6 ADV21230.1 - 0.028 14.5 0.9 0.057 13.5 0.3 1.7 2 0 0 2 2 2 0 Putative sensor Bax1-I PF01027.20 ADV21230.1 - 0.16 11.7 0.1 0.25 11.2 0.1 1.2 1 0 0 1 1 1 0 Inhibitor of apoptosis-promoting Bax1 Serglycin PF04360.12 ADV21230.1 - 3.8 7.4 10.7 2.1 8.3 0.6 2.6 3 0 0 3 3 3 0 Serglycin HEAT PF02985.22 ADV21231.1 - 7e-08 32.1 6.9 0.004 17.3 0.1 6.7 8 0 0 8 8 8 3 HEAT repeat HEAT_2 PF13646.6 ADV21231.1 - 1.7e-05 25.1 0.1 0.11 12.8 0.0 3.9 3 1 0 3 3 3 2 HEAT repeats Cnd1 PF12717.7 ADV21231.1 - 0.0029 17.7 0.0 0.074 13.1 0.0 2.8 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 ADV21231.1 - 0.62 10.6 3.6 66 4.2 0.0 4.3 4 0 0 4 4 4 0 HEAT-like repeat Pkinase PF00069.25 ADV21232.1 - 2e-54 184.7 0.0 4.5e-53 180.3 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV21232.1 - 2.3e-33 115.6 0.0 1.2e-32 113.2 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 ADV21232.1 - 1.2e-07 31.3 0.0 1.9e-07 30.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 ADV21232.1 - 0.0039 17.1 0.0 0.0068 16.4 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ADV21232.1 - 0.014 14.3 0.0 0.022 13.7 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 ADV21232.1 - 0.071 12.5 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Mito_carr PF00153.27 ADV21233.1 - 2.1e-35 120.5 5.2 3.7e-14 52.4 0.5 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Thiolase_N PF00108.23 ADV21234.1 - 4.5e-87 291.7 2.8 6.3e-87 291.2 2.8 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 ADV21234.1 - 2.8e-42 143.2 1.7 4.6e-41 139.3 1.0 2.5 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 ADV21234.1 - 5.1e-07 29.5 4.7 0.00015 21.5 0.4 2.9 2 1 1 3 3 3 2 Beta-ketoacyl synthase, N-terminal domain DUF2255 PF10012.9 ADV21234.1 - 0.088 13.0 0.1 0.16 12.1 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2255) CMD PF02627.20 ADV21235.1 - 5.5e-05 23.1 0.0 8.5e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Carboxymuconolactone decarboxylase family Adenine_glyco PF03352.13 ADV21235.1 - 0.085 12.6 0.0 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 Methyladenine glycosylase Ribosomal_L14 PF00238.19 ADV21236.1 - 2.2e-43 147.2 3.9 2.6e-43 147.0 3.9 1.1 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e Linker_histone PF00538.19 ADV21237.1 - 9.6e-19 67.5 0.1 9.6e-19 67.5 0.1 2.0 2 0 0 2 2 2 1 linker histone H1 and H5 family adh_short_C2 PF13561.6 ADV21238.1 - 5.3e-62 209.4 0.2 6.9e-62 209.1 0.2 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ADV21238.1 - 7.5e-42 143.0 0.4 1.2e-41 142.3 0.4 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ADV21238.1 - 2.8e-15 56.7 0.1 4.2e-15 56.1 0.1 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ADV21238.1 - 1.5e-05 24.6 0.1 4.1e-05 23.2 0.1 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 ADV21238.1 - 0.00013 21.3 0.1 0.00018 20.8 0.1 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 ADV21238.1 - 0.017 14.5 0.0 0.063 12.7 0.0 1.8 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase TPALS PF18178.1 ADV21238.1 - 0.13 11.7 0.1 0.25 10.7 0.1 1.5 1 0 0 1 1 1 0 TIR- and PNP-associating SLOG family Ribosomal_L5e PF17144.4 ADV21239.1 - 3.9e-80 267.6 0.0 6.6e-80 266.9 0.0 1.4 1 0 0 1 1 1 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.6 ADV21239.1 - 1.8e-34 118.5 4.4 3.7e-34 117.5 4.4 1.5 1 0 0 1 1 1 1 Ribosomal L18 C-terminal region DUF5388 PF17363.2 ADV21239.1 - 0.0075 16.4 0.0 0.18 12.0 0.0 2.4 2 0 0 2 2 2 1 Family of unknown function (DUF5388) MtrA PF04208.14 ADV21239.1 - 0.083 12.5 0.1 0.16 11.6 0.1 1.4 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit A DUF3591 PF12157.8 ADV21240.1 - 5.7e-152 506.4 0.1 5.7e-152 506.4 0.1 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF3591) zf-CCHC_6 PF15288.6 ADV21240.1 - 3.7e-08 33.1 2.9 8.1e-08 32.0 2.9 1.5 1 0 0 1 1 1 1 Zinc knuckle DUF1765 PF08578.10 ADV21242.1 - 3.8e-28 98.5 0.1 6.8e-28 97.6 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1765) Thioredoxin PF00085.20 ADV21243.1 - 2.2e-23 82.2 0.0 4.6e-23 81.2 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 ADV21243.1 - 0.0081 16.6 0.0 0.026 14.9 0.0 1.9 1 1 0 1 1 1 1 Thioredoxin-like domain OST3_OST6 PF04756.13 ADV21243.1 - 0.034 13.5 0.0 0.064 12.6 0.0 1.5 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family Herpes_UL49_1 PF03117.14 ADV21243.1 - 0.046 13.0 0.0 0.076 12.3 0.0 1.3 1 0 0 1 1 1 0 UL49 family Thioredoxin_8 PF13905.6 ADV21243.1 - 0.06 13.7 0.0 13 6.2 0.0 2.7 1 1 1 2 2 2 0 Thioredoxin-like Clr2_transil PF16761.5 ADV21244.1 - 1.6e-15 57.6 1.3 3.3e-15 56.6 0.1 2.1 2 0 0 2 2 2 1 Transcription-silencing protein, cryptic loci regulator Clr2 Clr2 PF10383.9 ADV21244.1 - 2e-13 51.4 0.0 1.4e-12 48.7 0.0 2.3 2 0 0 2 2 2 1 Transcription-silencing protein Clr2 Minor_capsid_2 PF11114.8 ADV21244.1 - 0.07 13.2 0.3 0.17 11.9 0.3 1.6 1 0 0 1 1 1 0 Minor capsid protein DUF2201_N PF13203.6 ADV21244.1 - 3.6 7.1 7.0 0.8 9.2 0.3 2.1 2 0 0 2 2 2 0 Putative metallopeptidase domain CN_hydrolase PF00795.22 ADV21246.1 - 1.9e-56 191.3 0.0 2.1e-56 191.1 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase GNVR PF13807.6 ADV21246.1 - 0.061 13.2 0.0 1 9.3 0.0 2.2 2 0 0 2 2 2 0 G-rich domain on putative tyrosine kinase F1F0-ATPsyn_F PF10791.9 ADV21247.1 - 1.9e-33 114.8 0.0 2.1e-33 114.6 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial F1-F0 ATP synthase subunit F of fungi Img2 PF05046.14 ADV21248.1 - 3.4e-23 81.7 0.0 4.6e-23 81.3 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) UQ_con PF00179.26 ADV21251.1 - 5e-44 149.4 0.0 6.6e-44 149.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UBA_3 PF09288.10 ADV21251.1 - 2.1e-12 46.7 0.0 3.3e-12 46.0 0.0 1.3 1 0 0 1 1 1 1 Fungal ubiquitin-associated domain Calsarcin PF05556.11 ADV21251.1 - 0.0053 16.3 0.0 0.0073 15.9 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-binding protein (Calsarcin) UBA PF00627.31 ADV21251.1 - 0.021 14.7 0.0 0.05 13.5 0.0 1.6 1 1 0 1 1 1 0 UBA/TS-N domain DUF1421 PF07223.11 ADV21251.1 - 0.11 12.4 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 UBA-like domain (DUF1421) SARS_X4 PF08779.10 ADV21251.1 - 0.12 12.5 0.0 0.26 11.5 0.0 1.5 1 0 0 1 1 1 0 SARS coronavirus X4 like ADH_N PF08240.12 ADV21252.1 - 3.7e-25 87.9 8.2 6.2e-25 87.2 8.2 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ADV21252.1 - 7.3e-14 51.9 0.1 1.3e-13 51.0 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 ADV21252.1 - 0.00045 19.6 0.1 0.00092 18.6 0.1 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 ADV21252.1 - 0.0014 18.1 0.3 0.0027 17.1 0.3 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 ADV21252.1 - 0.0081 16.3 0.1 0.014 15.6 0.1 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.18 ADV21252.1 - 0.032 14.1 0.6 0.13 12.1 0.8 1.9 1 1 1 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain LSM PF01423.22 ADV21253.1 - 5.5e-14 51.6 0.0 6.7e-14 51.3 0.0 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 ADV21253.1 - 0.0033 17.5 0.0 0.0045 17.1 0.0 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain Hairpins PF04877.12 ADV21253.1 - 0.1 12.2 2.1 0.11 12.1 2.1 1.1 1 0 0 1 1 1 0 HrpZ GRP PF07172.11 ADV21253.1 - 0.7 10.6 13.8 0.97 10.2 13.8 1.2 1 0 0 1 1 1 0 Glycine rich protein family Abhydrolase_6 PF12697.7 ADV21254.1 - 3.3e-09 37.7 0.3 5.4e-09 37.0 0.0 1.5 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 ADV21254.1 - 7.2e-08 32.4 0.0 1.1e-07 31.7 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ADV21254.1 - 1.6e-07 30.8 0.0 3.2e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.14 ADV21254.1 - 0.023 13.4 0.0 0.029 13.1 0.0 1.2 1 0 0 1 1 1 0 Ndr family Esterase PF00756.20 ADV21254.1 - 0.032 13.9 0.0 0.052 13.2 0.0 1.2 1 0 0 1 1 1 0 Putative esterase RRM_1 PF00076.22 ADV21255.1 - 9.3e-19 67.0 0.1 1.3e-18 66.6 0.1 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 ADV21255.1 - 0.00018 21.4 0.1 0.00043 20.2 0.1 1.6 1 1 0 1 1 1 1 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 ADV21255.1 - 0.0022 18.0 0.0 0.0042 17.1 0.0 1.5 1 1 0 1 1 1 1 RNA binding motif RRM_5 PF13893.6 ADV21255.1 - 0.011 15.3 0.0 0.014 15.0 0.0 1.1 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ADV21255.1 - 0.035 14.0 0.0 0.077 12.9 0.0 1.5 1 1 0 1 1 1 0 Occluded RNA-recognition motif RRM_7 PF16367.5 ADV21255.1 - 0.08 13.1 0.0 0.12 12.5 0.0 1.4 1 1 0 1 1 1 0 RNA recognition motif Glyco_transf_22 PF03901.17 ADV21256.1 - 1.1e-54 186.3 21.8 7.5e-43 147.3 15.0 2.2 2 0 0 2 2 2 2 Alg9-like mannosyltransferase family Ribonucleas_3_3 PF14622.6 ADV21257.1 - 9.6e-08 32.2 0.2 0.011 15.9 0.0 2.3 2 0 0 2 2 2 2 Ribonuclease-III-like Ribonuclease_3 PF00636.26 ADV21257.1 - 0.00011 22.7 0.0 0.00089 19.9 0.0 2.2 1 1 0 1 1 1 1 Ribonuclease III domain dsrm PF00035.26 ADV21257.1 - 0.00053 20.7 0.0 0.00098 19.8 0.0 1.5 1 0 0 1 1 1 1 Double-stranded RNA binding motif AbiJ_NTD3 PF18860.1 ADV21257.1 - 0.078 12.5 0.0 0.89 9.1 0.0 2.0 2 0 0 2 2 2 0 AbiJ N-terminal domain 3 G_glu_transpept PF01019.21 ADV21258.1 - 8.3e-147 490.0 0.0 9.6e-147 489.8 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase Proteasome PF00227.26 ADV21259.1 - 3.1e-37 127.9 0.0 4.2e-37 127.5 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Sld5 PF05916.11 ADV21260.1 - 1.8e-22 79.9 1.2 2.5e-22 79.4 1.2 1.2 1 0 0 1 1 1 1 GINS complex protein YchF-GTPase_C PF06071.13 ADV21262.1 - 3.7e-35 120.0 0.0 1.2e-34 118.3 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 ADV21262.1 - 3e-18 66.0 0.0 7.2e-18 64.7 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ADV21262.1 - 4.7e-06 26.2 0.0 1.6e-05 24.5 0.0 1.8 2 0 0 2 2 2 1 Ferrous iron transport protein B DUF615 PF04751.14 ADV21262.1 - 0.052 13.5 0.1 0.087 12.8 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF615) MeaB PF03308.16 ADV21262.1 - 0.07 12.1 0.0 0.22 10.5 0.0 1.7 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Voldacs PF03517.13 ADV21263.1 - 1.3e-22 80.4 0.0 1.8e-22 79.9 0.0 1.2 1 0 0 1 1 1 1 Regulator of volume decrease after cellular swelling PH_TFIIH PF08567.11 ADV21263.1 - 0.011 16.1 0.0 0.027 14.8 0.0 1.6 2 0 0 2 2 2 0 TFIIH p62 subunit, N-terminal domain Orn_Arg_deC_N PF02784.16 ADV21264.1 - 6.8e-72 241.8 0.0 8.8e-72 241.4 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 ADV21264.1 - 9.6e-16 57.8 0.0 2.6e-15 56.4 0.0 1.8 1 1 1 2 2 2 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Las1 PF04031.13 ADV21265.1 - 7.8e-31 107.3 0.0 1.7e-30 106.2 0.0 1.5 1 0 0 1 1 1 1 Las1-like Sugarporin_N PF11471.8 ADV21265.1 - 0.041 13.8 0.1 0.12 12.4 0.1 1.8 1 0 0 1 1 1 0 Maltoporin periplasmic N-terminal extension Peptidase_S24 PF00717.23 ADV21266.1 - 2.3e-09 37.1 0.0 4.4e-09 36.2 0.0 1.4 1 0 0 1 1 1 1 Peptidase S24-like Peptidase_S26 PF10502.9 ADV21266.1 - 9.3e-07 28.7 0.0 3.3e-06 26.9 0.0 1.9 1 1 0 1 1 1 1 Signal peptidase, peptidase S26 RuvA_N PF01330.21 ADV21266.1 - 0.18 11.9 0.0 0.58 10.3 0.0 1.9 2 0 0 2 2 2 0 RuvA N terminal domain DUF1275 PF06912.11 ADV21268.1 - 5e-31 108.1 17.4 6e-31 107.9 17.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1275) DUF4948 PF16306.5 ADV21268.1 - 0.088 12.6 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4948) IDO PF01231.18 ADV21269.1 - 4.9e-128 427.6 0.0 5.7e-128 427.4 0.0 1.0 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase DUF1864 PF08933.11 ADV21269.1 - 0.19 10.5 0.0 0.6 8.8 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1864) Fumble PF03630.14 ADV21270.1 - 2e-124 415.1 0.0 2.7e-124 414.7 0.0 1.2 1 0 0 1 1 1 1 Fumble DcpS_C PF11969.8 ADV21271.1 - 2.6e-16 60.1 0.2 1.6e-15 57.6 0.2 2.0 1 1 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding zf-C2HE PF16278.5 ADV21271.1 - 1.5e-14 54.1 1.4 2e-14 53.8 0.3 1.8 2 0 0 2 2 2 1 C2HE / C2H2 / C2HC zinc-binding finger HIT PF01230.23 ADV21271.1 - 6.5e-14 52.5 0.5 1.6e-12 48.0 0.1 2.7 2 1 0 2 2 2 1 HIT domain Adenylsucc_synt PF00709.21 ADV21272.1 - 1.7e-172 574.1 0.0 2e-172 573.9 0.0 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase Arrestin_N PF00339.29 ADV21273.1 - 1.5e-11 44.6 0.0 3.6e-10 40.1 0.0 2.2 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 ADV21273.1 - 3.9e-11 43.5 0.3 3.5e-09 37.2 0.3 2.4 1 1 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain LDB19 PF13002.7 ADV21273.1 - 0.0063 16.2 0.0 0.012 15.4 0.0 1.3 1 0 0 1 1 1 1 Arrestin_N terminal like Apolipoprotein PF01442.18 ADV21274.1 - 0.0032 17.4 2.4 0.0098 15.8 2.4 1.8 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain adh_short PF00106.25 ADV21275.1 - 3.1e-52 176.9 1.3 4.1e-52 176.5 1.3 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ADV21275.1 - 2.1e-34 119.1 0.6 2.6e-34 118.8 0.6 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ADV21275.1 - 4.8e-09 36.4 0.5 6.8e-09 35.9 0.5 1.2 1 0 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 ADV21275.1 - 0.00024 21.1 0.5 0.00057 19.8 0.1 1.8 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Epimerase PF01370.21 ADV21275.1 - 0.001 18.6 0.3 0.0025 17.3 0.3 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family ApbA PF02558.16 ADV21275.1 - 0.0038 16.9 0.0 0.0083 15.8 0.0 1.6 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Polysacc_synt_2 PF02719.15 ADV21275.1 - 0.005 16.0 0.6 0.049 12.8 0.0 2.1 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 ADV21275.1 - 0.0085 16.0 1.2 0.014 15.3 1.2 1.5 1 1 0 1 1 1 1 NAD(P)H-binding DAO PF01266.24 ADV21275.1 - 0.041 13.5 0.2 0.076 12.6 0.1 1.5 1 1 0 1 1 1 0 FAD dependent oxidoreductase GDP_Man_Dehyd PF16363.5 ADV21275.1 - 0.056 12.8 0.0 0.09 12.2 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase NmrA PF05368.13 ADV21275.1 - 0.075 12.6 1.0 0.12 11.9 0.2 1.8 2 0 0 2 2 2 0 NmrA-like family COX6A PF02046.15 ADV21276.1 - 6.4e-36 123.2 0.0 7.5e-36 123.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIa zf-PARP PF00645.18 ADV21277.1 - 1.5e-22 80.2 0.1 1.5e-22 80.2 0.1 2.8 3 0 0 3 3 3 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region Frag1 PF10277.9 ADV21278.1 - 3.7e-42 144.3 18.3 4.5e-42 144.1 18.3 1.1 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family DUF4231 PF14015.6 ADV21278.1 - 0.1 13.1 0.4 0.1 13.1 0.4 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF4231) CAF1A PF12253.8 ADV21279.1 - 0.23 11.6 12.4 0.91 9.7 12.4 2.0 1 0 0 1 1 1 0 Chromatin assembly factor 1 subunit A ApoO PF09769.9 ADV21279.1 - 0.31 11.0 1.6 2.6 8.0 0.2 2.8 3 0 0 3 3 3 0 Apolipoprotein O Syntaxin-6_N PF09177.11 ADV21279.1 - 0.99 10.0 11.3 0.17 12.5 2.0 3.7 3 1 0 3 3 3 0 Syntaxin 6, N-terminal Nop14 PF04147.12 ADV21279.1 - 4.5 5.4 14.4 0.4 8.8 9.2 1.7 2 0 0 2 2 2 0 Nop14-like family DDHD PF02862.17 ADV21279.1 - 6.1 6.9 7.6 6.6 6.8 0.1 2.9 2 1 0 2 2 2 0 DDHD domain His_Phos_2 PF00328.22 ADV21280.1 - 5.6e-44 151.0 0.0 7e-44 150.7 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Nucleo_P87 PF07267.11 ADV21281.1 - 0.66 8.8 3.2 1.1 8.0 3.2 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Glutaredoxin PF00462.24 ADV21282.1 - 1.5e-17 63.6 0.0 2.3e-17 63.0 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin Cmc1 PF08583.10 ADV21283.1 - 2.3e-17 62.8 1.7 4e-17 62.0 1.7 1.4 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like zf_Hakai PF18408.1 ADV21283.1 - 0.035 13.8 0.3 0.065 12.9 0.3 1.5 1 0 0 1 1 1 0 C2H2 Hakai zinc finger domain FrhB_FdhB_C PF04432.13 ADV21283.1 - 0.14 12.0 1.6 3.1 7.6 1.6 2.1 1 1 0 1 1 1 0 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus DUF202 PF02656.15 ADV21284.1 - 0.19 12.2 1.5 1 9.8 1.5 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF202) SQS_PSY PF00494.19 ADV21285.1 - 2.5e-33 115.7 0.0 4.6e-33 114.8 0.0 1.4 1 0 0 1 1 1 1 Squalene/phytoene synthase Podoplanin PF05808.11 ADV21285.1 - 0.044 13.9 0.0 0.078 13.1 0.0 1.3 1 0 0 1 1 1 0 Podoplanin Peptidase_M24 PF00557.24 ADV21286.1 - 8.4e-56 189.0 0.1 1.4e-55 188.2 0.1 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 ADV21286.1 - 5.8e-38 129.4 0.0 1.4e-37 128.2 0.0 1.6 2 0 0 2 2 2 1 Aminopeptidase P, N-terminal domain FTR1 PF03239.14 ADV21288.1 - 1.8e-65 221.2 13.8 7.1e-41 140.3 7.4 2.1 1 1 1 2 2 2 2 Iron permease FTR1 family Nucleos_tra2_C PF07662.13 ADV21288.1 - 0.011 15.6 4.6 0.49 10.2 0.3 2.4 2 0 0 2 2 2 0 Na+ dependent nucleoside transporter C-terminus DUF1440 PF07274.12 ADV21288.1 - 0.061 13.7 1.2 0.28 11.5 1.3 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1440) GWT1 PF06423.12 ADV21288.1 - 1 9.4 0.0 1 9.4 0.0 2.7 4 0 0 4 4 4 0 GWT1 TPR_1 PF00515.28 ADV21289.1 - 1.2e-29 100.9 8.2 2.7e-06 27.0 0.9 8.1 8 0 0 8 8 8 6 Tetratricopeptide repeat ANAPC8 PF04049.13 ADV21289.1 - 2.1e-25 89.4 0.0 4.7e-25 88.3 0.0 1.6 1 0 0 1 1 1 1 Anaphase promoting complex subunit 8 / Cdc23 TPR_8 PF13181.6 ADV21289.1 - 4.7e-23 79.4 6.5 7.2e-05 22.7 0.0 7.8 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_2 PF07719.17 ADV21289.1 - 3.7e-19 67.2 11.3 0.019 15.1 0.8 8.2 8 0 0 8 8 7 5 Tetratricopeptide repeat TPR_14 PF13428.6 ADV21289.1 - 2e-14 53.0 17.8 0.0074 17.0 0.1 9.7 7 1 3 10 10 9 6 Tetratricopeptide repeat TPR_12 PF13424.6 ADV21289.1 - 7.1e-14 51.8 6.0 0.00035 20.8 0.2 5.5 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 ADV21289.1 - 6.5e-10 38.5 6.0 5.7e-07 29.1 1.3 4.1 4 1 1 5 5 5 2 TPR repeat TPR_7 PF13176.6 ADV21289.1 - 7.4e-10 38.2 11.2 0.0019 18.1 0.0 7.5 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_16 PF13432.6 ADV21289.1 - 1.1e-09 38.7 7.3 4.6e-05 24.0 0.2 5.8 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_9 PF13371.6 ADV21289.1 - 7.4e-09 35.6 19.9 0.00051 20.1 0.0 7.0 6 1 0 7 7 7 3 Tetratricopeptide repeat TPR_17 PF13431.6 ADV21289.1 - 1.3e-08 34.6 3.9 0.019 15.3 0.2 5.6 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 ADV21289.1 - 9.5e-08 32.4 7.9 0.08 13.5 0.1 6.6 7 0 0 7 7 6 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ADV21289.1 - 0.0023 18.1 10.6 0.31 11.3 0.5 5.0 4 1 1 5 5 5 1 Anaphase-promoting complex, cyclosome, subunit 3 NARP1 PF12569.8 ADV21289.1 - 0.0032 16.4 0.7 0.019 13.9 0.0 2.2 2 0 0 2 2 2 1 NMDA receptor-regulated protein 1 ChAPs PF09295.10 ADV21289.1 - 0.0033 16.5 1.1 6.4 5.7 0.0 3.3 2 2 1 3 3 3 2 ChAPs (Chs5p-Arf1p-binding proteins) TPR_6 PF13174.6 ADV21289.1 - 0.032 14.9 15.0 9.3 7.1 0.4 7.9 9 1 1 10 10 8 0 Tetratricopeptide repeat TPR_10 PF13374.6 ADV21289.1 - 0.12 12.2 9.5 2.4 8.1 0.0 5.6 7 0 0 7 7 7 0 Tetratricopeptide repeat Peptidase_S10 PF00450.22 ADV21290.1 - 5.8e-82 276.3 0.2 7.1e-82 276.0 0.2 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase CIA30 PF08547.12 ADV21291.1 - 1.3e-15 57.8 0.0 4.9e-07 29.9 0.0 2.4 2 1 0 2 2 2 2 Complex I intermediate-associated protein 30 (CIA30) 4HBT PF03061.22 ADV21292.1 - 0.0024 18.2 0.1 4 7.9 0.0 3.4 3 0 0 3 3 3 2 Thioesterase superfamily SH3_1 PF00018.28 ADV21293.1 - 7.3e-15 54.3 1.1 4.5e-10 39.0 0.1 2.9 2 1 0 2 2 2 2 SH3 domain SAM_2 PF07647.17 ADV21293.1 - 1.7e-12 47.2 0.0 2.7e-12 46.6 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_9 PF14604.6 ADV21293.1 - 1.4e-10 40.8 2.2 4.1e-07 29.7 0.3 2.7 2 0 0 2 2 2 2 Variant SH3 domain SAM_1 PF00536.30 ADV21293.1 - 2.2e-10 40.8 0.0 3.5e-10 40.2 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RA PF00788.23 ADV21293.1 - 9e-10 39.1 0.1 2.5e-09 37.6 0.0 1.7 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain SH3_2 PF07653.17 ADV21293.1 - 1.4e-05 24.7 0.7 0.00014 21.5 0.2 2.4 2 0 0 2 2 2 1 Variant SH3 domain SH3_3 PF08239.11 ADV21293.1 - 0.00031 21.0 4.7 0.0073 16.6 1.2 2.7 2 0 0 2 2 2 1 Bacterial SH3 domain Amidinotransf PF02274.17 ADV21293.1 - 0.2 10.7 0.0 0.29 10.2 0.0 1.1 1 0 0 1 1 1 0 Amidinotransferase R3H PF01424.22 ADV21294.1 - 3.7e-11 42.8 0.2 8e-11 41.8 0.2 1.6 1 0 0 1 1 1 1 R3H domain zf-NF-X1 PF01422.17 ADV21294.1 - 0.00024 21.1 11.2 0.00024 21.1 11.2 13.1 13 0 0 13 13 13 7 NF-X1 type zinc finger Gly_transf_sug PF04488.15 ADV21295.1 - 6.7e-07 29.9 0.0 1.4e-06 28.8 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Caps_synth PF05704.12 ADV21295.1 - 0.035 13.5 0.3 0.058 12.8 0.3 1.2 1 0 0 1 1 1 0 Capsular polysaccharide synthesis protein DUF1010 PF06231.11 ADV21295.1 - 0.1 13.1 0.3 0.49 10.9 0.3 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1010) ABC_membrane PF00664.23 ADV21296.1 - 2.6e-67 227.3 36.3 9.3e-35 120.6 9.2 3.1 3 0 0 3 3 3 2 ABC transporter transmembrane region ABC_tran PF00005.27 ADV21296.1 - 1.5e-51 174.5 0.1 1.5e-28 100.0 0.0 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 ADV21296.1 - 1.1e-06 28.2 4.5 0.0032 16.9 0.4 3.9 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 ADV21296.1 - 7.9e-06 26.3 0.2 0.049 14.0 0.1 2.7 2 0 0 2 2 2 2 AAA ATPase domain MMR_HSR1 PF01926.23 ADV21296.1 - 0.00034 20.7 1.1 0.89 9.7 0.1 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ADV21296.1 - 0.00042 20.3 0.1 0.28 11.1 0.0 2.9 3 0 0 3 3 3 1 RsgA GTPase Dynamin_N PF00350.23 ADV21296.1 - 0.0014 18.7 0.5 0.065 13.3 0.0 2.5 2 0 0 2 2 2 1 Dynamin family AAA_29 PF13555.6 ADV21296.1 - 0.0014 18.3 0.9 0.92 9.3 0.1 3.4 4 0 0 4 4 4 1 P-loop containing region of AAA domain MeaB PF03308.16 ADV21296.1 - 0.016 14.2 0.6 0.084 11.8 0.1 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB DUF815 PF05673.13 ADV21296.1 - 0.021 14.0 0.3 1.7 7.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Zeta_toxin PF06414.12 ADV21296.1 - 0.026 13.8 0.1 1.2 8.4 0.0 2.5 2 0 0 2 2 2 0 Zeta toxin AAA_22 PF13401.6 ADV21296.1 - 0.038 14.3 1.4 0.72 10.1 0.0 3.0 3 0 0 3 3 3 0 AAA domain AAA_25 PF13481.6 ADV21296.1 - 0.12 12.0 0.0 13 5.3 0.0 2.5 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 ADV21296.1 - 0.16 11.7 0.1 9.5 5.9 0.1 2.6 2 0 0 2 2 2 0 IstB-like ATP binding protein DUF87 PF01935.17 ADV21296.1 - 0.24 11.5 6.6 0.52 10.4 0.2 3.1 3 0 0 3 3 3 0 Helicase HerA, central domain UCR_UQCRX_QCR9 PF05365.12 ADV21296.1 - 1.8 8.6 4.5 0.52 10.3 0.1 2.5 2 0 0 2 2 2 0 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like Tmemb_14 PF03647.13 ADV21297.1 - 6.5e-13 49.2 3.8 7.8e-13 49.0 3.8 1.0 1 0 0 1 1 1 1 Transmembrane proteins 14C Peptidase_M19 PF01244.21 ADV21298.1 - 5.3e-99 331.4 0.0 7e-99 331.0 0.0 1.1 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) WD40 PF00400.32 ADV21299.1 - 7.5e-65 213.3 25.2 4.7e-07 30.4 0.1 11.8 12 0 0 12 12 11 10 WD domain, G-beta repeat Utp13 PF08625.11 ADV21299.1 - 4.1e-50 169.4 0.0 6.1e-50 168.8 0.0 1.3 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain ANAPC4_WD40 PF12894.7 ADV21299.1 - 8.2e-10 38.9 0.7 0.22 11.8 0.1 6.4 5 2 1 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ADV21299.1 - 2.5e-07 29.8 4.5 0.045 12.4 0.0 5.5 5 1 1 6 6 6 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ADV21299.1 - 2.8e-06 26.9 0.0 4.2e-05 23.0 0.0 2.7 3 0 0 3 3 3 1 WD40-like domain Ge1_WD40 PF16529.5 ADV21299.1 - 2.1e-05 23.6 0.2 0.24 10.3 0.0 4.0 3 1 1 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein VID27 PF08553.10 ADV21299.1 - 0.00023 20.4 0.2 0.38 9.8 0.0 2.9 3 0 0 3 3 3 2 VID27 C-terminal WD40-like domain Cytochrom_D1 PF02239.16 ADV21299.1 - 0.013 14.0 0.1 13 4.2 0.0 3.6 3 1 0 3 3 3 0 Cytochrome D1 heme domain Nucleoporin_N PF08801.11 ADV21299.1 - 0.03 13.1 4.4 1.3 7.7 0.1 4.4 2 1 2 5 5 5 0 Nup133 N terminal like Mcl1_mid PF12341.8 ADV21299.1 - 0.03 13.7 0.0 0.12 11.7 0.0 1.9 2 0 0 2 2 2 0 Minichromosome loss protein, Mcl1, middle region ICL PF00463.21 ADV21299.1 - 0.14 10.7 0.0 0.21 10.0 0.0 1.2 1 0 0 1 1 1 0 Isocitrate lyase family Spc7_N PF15402.6 ADV21299.1 - 0.31 9.2 1.5 0.46 8.7 1.5 1.1 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 DUF572 PF04502.13 ADV21300.1 - 4e-70 237.0 6.9 4.8e-70 236.8 6.9 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF572) DUF866 PF05907.13 ADV21300.1 - 0.016 15.1 0.2 0.031 14.2 0.2 1.4 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF866) TF_Zn_Ribbon PF08271.12 ADV21300.1 - 0.021 14.3 4.0 0.029 13.9 0.9 2.4 2 0 0 2 2 2 0 TFIIB zinc-binding zf-ACC PF17848.1 ADV21300.1 - 0.53 10.4 3.5 5 7.3 0.4 2.5 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain DUF2175 PF09943.9 ADV21300.1 - 1.1 9.6 0.1 1.1 9.6 0.1 2.6 3 1 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2175) RR_TM4-6 PF06459.12 ADV21300.1 - 4.3 7.1 8.3 6.2 6.6 8.3 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 NUDIX PF00293.28 ADV21301.1 - 1e-11 45.0 0.1 1e-10 41.8 0.0 2.0 2 0 0 2 2 2 1 NUDIX domain AMPK1_CBM PF16561.5 ADV21302.1 - 2.2e-16 59.9 0.1 4.3e-16 58.9 0.1 1.4 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase CBM_48 PF02922.18 ADV21302.1 - 0.00031 21.0 0.3 0.0006 20.1 0.3 1.4 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) CBM53 PF16760.5 ADV21302.1 - 0.25 11.9 0.8 0.57 10.8 0.8 1.5 1 0 0 1 1 1 0 Starch/carbohydrate-binding module (family 53) Flavin_Reduct PF01613.18 ADV21304.1 - 2.9e-20 72.9 0.0 3.3e-20 72.7 0.0 1.0 1 0 0 1 1 1 1 Flavin reductase like domain CLASP_N PF12348.8 ADV21305.1 - 2e-81 272.9 0.1 4.8e-71 238.9 0.0 4.1 4 0 0 4 4 4 3 CLASP N terminal HEAT PF02985.22 ADV21305.1 - 0.00078 19.5 0.6 21 5.7 0.0 5.1 4 1 1 5 5 5 1 HEAT repeat Tfb2 PF03849.14 ADV21305.1 - 0.081 11.9 0.1 0.13 11.2 0.1 1.2 1 0 0 1 1 1 0 Transcription factor Tfb2 DUF2458 PF10454.9 ADV21305.1 - 0.18 11.5 1.1 0.5 10.0 1.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2458) RRM_1 PF00076.22 ADV21307.1 - 7e-62 205.2 0.0 9.7e-16 57.4 0.0 5.4 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ADV21307.1 - 5.4e-11 42.2 0.0 0.16 11.9 0.0 5.5 5 1 0 5 5 5 4 Occluded RNA-recognition motif Limkain-b1 PF11608.8 ADV21307.1 - 7.3e-05 22.8 0.0 0.37 10.9 0.0 4.7 5 0 0 5 5 5 1 Limkain b1 RRM_7 PF16367.5 ADV21307.1 - 0.00059 19.9 0.0 0.0061 16.6 0.0 2.6 3 0 0 3 3 3 1 RNA recognition motif PHM7_cyt PF14703.6 ADV21307.1 - 0.0026 18.0 2.5 95 3.2 0.0 5.8 6 1 1 7 7 7 0 Cytosolic domain of 10TM putative phosphate transporter Nup35_RRM_2 PF14605.6 ADV21307.1 - 0.011 15.8 0.0 28 4.8 0.0 4.4 5 0 0 5 5 5 0 Nup53/35/40-type RNA recognition motif Lum_binding PF00677.17 ADV21308.1 - 3.4e-44 148.8 1.1 2.4e-22 78.7 0.2 2.2 2 0 0 2 2 2 2 Lumazine binding domain YabP PF07873.11 ADV21308.1 - 0.059 13.2 0.0 3.8 7.4 0.0 2.6 2 0 0 2 2 2 0 YabP family DUF2102 PF09875.9 ADV21308.1 - 0.077 12.7 0.4 0.77 9.5 0.1 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2102) DUF3759 PF12585.8 ADV21310.1 - 3.2e-40 136.1 3.9 3.5e-40 135.9 3.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3759) TPR_16 PF13432.6 ADV21310.1 - 0.033 14.8 2.1 0.098 13.3 0.1 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat Erg28 PF03694.13 ADV21311.1 - 3.3e-34 117.6 0.6 3.9e-34 117.3 0.6 1.1 1 0 0 1 1 1 1 Erg28 like protein CTU2 PF10288.9 ADV21313.1 - 9.6e-20 70.9 0.0 2.4e-19 69.6 0.0 1.7 1 0 0 1 1 1 1 Cytoplasmic tRNA 2-thiolation protein 2 DZR PF12773.7 ADV21313.1 - 5.9 7.0 8.6 24 5.1 1.6 2.9 2 1 0 2 2 2 0 Double zinc ribbon zf-C3HC4_3 PF13920.6 ADV21313.1 - 7.9 6.4 7.4 33 4.4 0.2 3.2 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) SNF5 PF04855.12 ADV21314.1 - 1e-63 215.3 7.8 1.3e-63 214.9 7.8 1.1 1 0 0 1 1 1 1 SNF5 / SMARCB1 / INI1 YL1 PF05764.13 ADV21314.1 - 0.0012 19.0 13.9 0.0012 19.0 13.9 2.4 2 0 0 2 2 2 1 YL1 nuclear protein DDHD PF02862.17 ADV21314.1 - 0.011 15.9 0.2 0.018 15.2 0.2 1.4 1 0 0 1 1 1 0 DDHD domain FmiP_Thoc5 PF09766.9 ADV21314.1 - 0.4 9.9 8.5 0.71 9.1 8.5 1.4 1 0 0 1 1 1 0 Fms-interacting protein/Thoc5 CDC45 PF02724.14 ADV21314.1 - 0.56 8.4 20.6 0.0047 15.3 12.1 1.6 2 0 0 2 2 2 0 CDC45-like protein TCP PF03634.13 ADV21314.1 - 1.2 9.7 13.4 2.6 8.6 13.4 1.5 1 0 0 1 1 1 0 TCP family transcription factor Connexin PF00029.19 ADV21314.1 - 1.5 8.5 4.6 2.4 7.8 4.6 1.3 1 0 0 1 1 1 0 Connexin Presenilin PF01080.17 ADV21314.1 - 1.7 7.3 7.7 2.5 6.7 7.7 1.2 1 0 0 1 1 1 0 Presenilin Hid1 PF12722.7 ADV21314.1 - 1.8 6.6 4.9 2.3 6.3 4.9 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RR_TM4-6 PF06459.12 ADV21314.1 - 1.9 8.3 12.6 3.6 7.3 12.6 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CPSF100_C PF13299.6 ADV21314.1 - 2.5 8.2 8.3 5.1 7.2 8.3 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Ribosomal_S19e PF01090.19 ADV21316.1 - 8.9e-53 177.7 0.0 1e-52 177.5 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e Ribosomal_60s PF00428.19 ADV21316.1 - 0.16 12.5 9.2 0.27 11.9 9.2 1.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein PBP_sp32 PF07222.12 ADV21316.1 - 0.34 10.3 4.8 0.42 10.0 4.8 1.1 1 0 0 1 1 1 0 Proacrosin binding protein sp32 CwfJ_C_1 PF04677.15 ADV21317.1 - 1.6e-30 105.5 0.0 4.7e-30 104.0 0.0 1.7 2 0 0 2 2 2 1 Protein similar to CwfJ C-terminus 1 zf-CCHC_2 PF13696.6 ADV21317.1 - 5.2e-30 102.9 22.3 1.2e-11 44.2 2.3 3.5 3 0 0 3 3 3 3 Zinc knuckle CwfJ_C_2 PF04676.14 ADV21317.1 - 4.3e-11 43.6 0.0 7.3e-11 42.8 0.0 1.3 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 zf-CCHC PF00098.23 ADV21317.1 - 2e-08 33.9 14.8 0.0032 17.5 0.9 3.8 3 0 0 3 3 3 3 Zinc knuckle eIF3g PF12353.8 ADV21317.1 - 1.7e-05 25.2 12.1 0.11 12.9 1.0 3.4 2 1 1 3 3 3 3 Eukaryotic translation initiation factor 3 subunit G zf-CCHC_3 PF13917.6 ADV21317.1 - 0.0068 16.4 6.6 0.098 12.6 0.2 2.7 1 1 1 2 2 2 2 Zinc knuckle RRM_1 PF00076.22 ADV21318.1 - 1.1e-11 44.4 0.0 1.6e-11 43.9 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ADV21318.1 - 0.12 12.0 0.0 0.18 11.4 0.0 1.2 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Zip PF02535.22 ADV21319.1 - 4.4e-54 183.9 16.2 1.4e-52 179.0 16.2 2.0 1 1 0 1 1 1 1 ZIP Zinc transporter CH PF00307.31 ADV21320.1 - 2.9e-48 162.6 0.1 8.2e-26 90.3 0.0 2.5 2 0 0 2 2 2 2 Calponin homology (CH) domain EFhand_Ca_insen PF08726.10 ADV21320.1 - 1.7e-23 82.5 0.2 4e-23 81.3 0.2 1.7 1 0 0 1 1 1 1 Ca2+ insensitive EF hand CAMSAP_CH PF11971.8 ADV21320.1 - 8.1e-12 44.8 0.0 5.8e-09 35.7 0.0 2.7 2 0 0 2 2 2 2 CAMSAP CH domain CH_2 PF06294.11 ADV21320.1 - 0.0032 17.6 0.1 2 8.6 0.0 3.0 3 0 0 3 3 3 2 CH-like domain in sperm protein RyR PF02026.16 ADV21320.1 - 0.074 13.3 0.3 9.1 6.5 0.0 3.0 2 0 0 2 2 2 0 RyR domain OmpH PF03938.14 ADV21320.1 - 0.37 11.1 3.4 0.55 10.6 1.8 2.1 2 1 0 2 2 2 0 Outer membrane protein (OmpH-like) Cofilin_ADF PF00241.20 ADV21321.1 - 3.5e-39 133.3 0.1 3.9e-39 133.2 0.1 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein NaeI PF09126.10 ADV21321.1 - 0.044 13.0 0.0 0.055 12.7 0.0 1.1 1 0 0 1 1 1 0 Restriction endonuclease NaeI zf-AN1 PF01428.16 ADV21322.1 - 9.5e-11 41.7 3.4 1.8e-10 40.8 3.4 1.5 1 0 0 1 1 1 1 AN1-like Zinc finger DUF3818 PF12825.7 ADV21323.1 - 2.7e-129 431.1 0.3 3.9e-129 430.5 0.3 1.2 1 0 0 1 1 1 1 Domain of unknown function in PX-proteins (DUF3818) PXB PF12828.7 ADV21323.1 - 9.6e-27 93.5 2.4 1.7e-26 92.7 1.0 2.2 2 0 0 2 2 2 1 PX-associated PX PF00787.24 ADV21323.1 - 9.4e-12 44.9 0.7 9.7e-11 41.7 0.0 2.9 3 0 0 3 3 3 1 PX domain Spt5_N PF11942.8 ADV21323.1 - 0.0067 17.4 5.7 0.0067 17.4 5.7 3.5 4 0 0 4 4 4 1 Spt5 transcription elongation factor, acidic N-terminal CDC45 PF02724.14 ADV21323.1 - 7.2 4.8 7.9 15 3.7 7.9 1.4 1 0 0 1 1 1 0 CDC45-like protein Acetyltransf_1 PF00583.25 ADV21324.1 - 1.2e-14 54.6 0.0 1.6e-14 54.2 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ADV21324.1 - 6.7e-05 23.2 0.0 0.00012 22.5 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ADV21324.1 - 0.0058 16.6 0.0 0.011 15.7 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.7 ADV21324.1 - 0.0067 16.4 0.0 0.013 15.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 ADV21324.1 - 0.11 12.7 0.0 0.18 11.9 0.0 1.6 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Nsp1_C PF05064.13 ADV21324.1 - 0.12 12.2 0.1 0.21 11.4 0.1 1.4 1 0 0 1 1 1 0 Nsp1-like C-terminal region DAO PF01266.24 ADV21325.1 - 2e-34 119.7 0.0 2.4e-34 119.5 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ADV21325.1 - 0.0011 18.3 0.0 0.37 10.0 0.0 2.7 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 ADV21325.1 - 0.0043 16.0 0.3 2.2 7.0 0.0 2.5 3 0 0 3 3 3 2 Tryptophan halogenase GIDA PF01134.22 ADV21325.1 - 0.0045 16.1 0.0 0.1 11.6 0.0 2.1 2 0 0 2 2 2 1 Glucose inhibited division protein A Ldh_1_N PF00056.23 ADV21325.1 - 0.034 14.3 0.1 0.099 12.7 0.0 1.8 2 0 0 2 2 2 0 lactate/malate dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 ADV21325.1 - 0.065 13.3 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NAD_binding_8 PF13450.6 ADV21325.1 - 0.092 13.0 0.0 0.22 11.8 0.0 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain ThiF PF00899.21 ADV21325.1 - 0.1 11.9 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 ThiF family Filament PF00038.21 ADV21326.1 - 0.047 13.3 13.9 0.077 12.6 3.0 2.7 3 0 0 3 3 3 0 Intermediate filament protein SAM_Exu PF18609.1 ADV21326.1 - 0.21 11.7 0.7 0.74 9.9 0.7 2.0 1 0 0 1 1 1 0 Exuperantia SAM-like domain DUF3770 PF12603.8 ADV21326.1 - 0.33 10.4 3.4 0.49 9.9 0.3 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3770) HAUS5 PF14817.6 ADV21326.1 - 0.84 8.3 14.1 0.22 10.2 0.2 2.4 2 1 0 2 2 2 0 HAUS augmin-like complex subunit 5 FlxA PF14282.6 ADV21326.1 - 4.3 7.4 10.3 1.3 9.0 4.7 2.7 2 0 0 2 2 2 0 FlxA-like protein Sin3a_C PF16879.5 ADV21327.1 - 2.5e-85 286.7 0.1 6.4e-84 282.0 0.0 2.7 3 0 0 3 3 3 1 C-terminal domain of Sin3a protein Sin3_corepress PF08295.12 ADV21327.1 - 2.3e-41 139.8 0.5 4.7e-41 138.8 0.5 1.6 1 0 0 1 1 1 1 Sin3 family co-repressor PAH PF02671.21 ADV21327.1 - 3.1e-35 120.0 3.7 2.5e-18 65.9 2.3 3.6 3 0 0 3 3 3 3 Paired amphipathic helix repeat 2OG-FeII_Oxy_2 PF13532.6 ADV21328.1 - 3.8e-09 37.0 0.0 1.3e-08 35.3 0.0 1.7 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Flavokinase PF01687.17 ADV21329.1 - 1e-32 112.7 0.0 1.3e-32 112.4 0.0 1.1 1 0 0 1 1 1 1 Riboflavin kinase Porin_3 PF01459.22 ADV21330.1 - 5.1e-76 255.7 3.0 5.8e-76 255.5 3.0 1.0 1 0 0 1 1 1 1 Eukaryotic porin tRNA_int_endo PF01974.17 ADV21331.1 - 3.7e-14 52.5 0.0 8.2e-14 51.4 0.0 1.6 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain Nop25 PF09805.9 ADV21331.1 - 0.00059 20.3 2.2 0.001 19.5 2.2 1.3 1 0 0 1 1 1 1 Nucleolar protein 12 (25kDa) tRNA_int_endo_N PF02778.14 ADV21331.1 - 0.0044 16.6 0.1 0.024 14.3 0.1 2.1 2 0 0 2 2 2 1 tRNA intron endonuclease, N-terminal domain HEM4 PF02602.15 ADV21332.1 - 0.19 11.1 0.0 0.26 10.6 0.0 1.2 1 0 0 1 1 1 0 Uroporphyrinogen-III synthase HemD PITH PF06201.13 ADV21333.1 - 1.1e-25 90.6 0.0 1.5e-25 90.2 0.0 1.2 1 0 0 1 1 1 1 PITH domain PapD_N PF00345.20 ADV21333.1 - 0.13 12.1 0.0 4.5 7.2 0.0 2.4 2 0 0 2 2 2 0 Pili and flagellar-assembly chaperone, PapD N-terminal domain Pkinase PF00069.25 ADV21335.1 - 6.4e-47 160.1 0.4 1.2e-46 159.2 0.4 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV21335.1 - 1.4e-22 80.2 0.2 3.8e-22 78.8 0.1 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase RIO1 PF01163.22 ADV21335.1 - 0.0019 17.9 0.2 0.019 14.6 0.2 2.4 1 1 0 1 1 1 1 RIO1 family Pkinase_fungal PF17667.1 ADV21335.1 - 0.0027 16.6 0.1 0.0027 16.6 0.1 1.9 2 0 0 2 2 2 1 Fungal protein kinase Pox_ser-thr_kin PF05445.11 ADV21335.1 - 0.019 13.9 0.0 0.03 13.3 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase ATP-synt_J PF04911.12 ADV21336.1 - 1.3e-19 69.5 2.1 1.5e-19 69.3 2.1 1.0 1 0 0 1 1 1 1 ATP synthase j chain DUF4010 PF13194.6 ADV21336.1 - 0.058 13.1 0.1 0.064 12.9 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4010) RNase_T PF00929.24 ADV21337.1 - 1.5e-13 51.6 0.0 3.1e-13 50.6 0.0 1.5 1 1 0 1 1 1 1 Exonuclease DNA_pol_A_exo1 PF01612.20 ADV21337.1 - 0.00052 19.8 0.0 0.0011 18.7 0.0 1.4 1 1 0 1 1 1 1 3'-5' exonuclease Cu-oxidase_2 PF07731.14 ADV21338.1 - 4.5e-38 130.1 12.2 6.6e-38 129.5 2.8 3.7 3 1 0 3 3 3 1 Multicopper oxidase Cu-oxidase_3 PF07732.15 ADV21338.1 - 1e-34 119.1 3.4 2.4e-30 105.0 2.2 3.0 3 0 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 ADV21338.1 - 1.7e-31 109.5 6.7 1.4e-30 106.5 1.5 3.6 4 1 0 4 4 4 1 Multicopper oxidase Cupredoxin_1 PF13473.6 ADV21338.1 - 0.0042 17.2 0.0 1.9 8.6 0.0 4.4 4 2 0 4 4 4 1 Cupredoxin-like domain Med26 PF08711.11 ADV21339.1 - 1.3e-08 34.7 0.0 2.8e-08 33.7 0.0 1.6 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Rap_GAP PF02145.15 ADV21340.1 - 1.5e-44 151.8 0.0 3e-44 150.8 0.0 1.5 1 0 0 1 1 1 1 Rap/ran-GAP Tuberin PF03542.16 ADV21340.1 - 9e-34 117.1 7.1 3e-30 105.5 5.1 3.1 2 1 0 2 2 2 2 Tuberin DUF3384 PF11864.8 ADV21340.1 - 2.1e-06 26.9 2.3 4.1e-06 26.0 0.1 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF3384) DUF572 PF04502.13 ADV21340.1 - 0.00024 20.8 2.9 0.001 18.8 0.2 2.5 2 0 0 2 2 2 1 Family of unknown function (DUF572) NUFIP1 PF10453.9 ADV21341.1 - 5.7e-17 61.3 3.5 1.9e-16 59.6 3.5 1.9 1 0 0 1 1 1 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) zf-CCCH PF00642.24 ADV21341.1 - 1.6e-08 34.2 2.0 2.9e-08 33.4 2.0 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 ADV21341.1 - 4.9e-07 29.6 7.7 9.5e-07 28.7 7.7 1.5 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH_4 PF18044.1 ADV21341.1 - 3.9e-06 26.5 3.3 7.3e-06 25.6 3.3 1.5 1 0 0 1 1 1 1 CCCH-type zinc finger zf-CCCH_2 PF14608.6 ADV21341.1 - 0.0015 19.0 5.0 0.0015 19.0 5.0 2.2 2 0 0 2 2 2 1 RNA-binding, Nab2-type zinc finger BUD22 PF09073.10 ADV21341.1 - 0.0046 16.4 7.7 0.0046 16.4 7.7 2.5 3 1 0 3 3 3 1 BUD22 Torus PF16131.5 ADV21341.1 - 0.031 15.0 0.0 0.09 13.5 0.0 1.9 1 0 0 1 1 1 0 Torus domain DUF1644 PF07800.12 ADV21341.1 - 0.074 13.1 0.5 0.48 10.5 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1644) eRF1_2 PF03464.15 ADV21342.1 - 8.8e-43 145.8 0.0 1.4e-42 145.2 0.0 1.3 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 ADV21342.1 - 1.2e-38 132.0 0.2 2.7e-38 130.9 0.2 1.6 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.15 ADV21342.1 - 1.5e-16 60.6 0.0 2.4e-16 59.9 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 1 acVLRF1 PF18859.1 ADV21342.1 - 1.5e-10 41.5 0.1 2.6e-10 40.7 0.1 1.4 1 0 0 1 1 1 1 Actinobacteria/chloroflexi VLRF1 release factor baeRF_family10 PF18854.1 ADV21342.1 - 1.9e-08 34.7 0.1 4.2e-08 33.5 0.1 1.6 2 0 0 2 2 2 1 Bacterial archaeo-eukaryotic release factor family 10 DUF3440 PF11922.8 ADV21342.1 - 0.032 13.9 0.0 0.063 13.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3440) Pkinase PF00069.25 ADV21343.1 - 6.1e-22 78.2 0.0 1.3e-21 77.2 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV21343.1 - 1.9e-11 43.7 0.0 3.8e-11 42.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase RRM_1 PF00076.22 ADV21344.1 - 1.8e-14 53.3 0.0 1.5e-13 50.3 0.0 2.5 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ADV21344.1 - 0.00077 19.1 0.0 0.0019 17.8 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Na_Ca_ex PF01699.24 ADV21345.1 - 1.5e-21 76.9 32.8 1.7e-13 50.8 10.5 3.0 3 0 0 3 3 3 2 Sodium/calcium exchanger protein YccF PF03733.13 ADV21345.1 - 5.7e-12 46.1 10.3 5.7e-12 46.1 10.3 3.8 2 0 0 2 2 2 1 Inner membrane component domain PapA_C PF16911.5 ADV21345.1 - 0.25 11.4 1.4 9.8 6.3 0.5 2.6 2 0 0 2 2 2 0 Phthiocerol/phthiodiolone dimycocerosyl transferase C-terminus Peroxin-3 PF04882.12 ADV21346.1 - 6.2e-126 421.1 0.0 1.1e-125 420.3 0.0 1.4 1 1 0 1 1 1 1 Peroxin-3 DnaJ PF00226.31 ADV21347.1 - 8.1e-16 57.9 0.6 8.1e-16 57.9 0.6 2.2 2 0 0 2 2 2 1 DnaJ domain Sec63 PF02889.16 ADV21347.1 - 1.9e-12 46.9 0.0 1.3e-11 44.1 0.0 2.3 2 1 0 2 2 2 1 Sec63 Brl domain Halogen_Hydrol PF10112.9 ADV21347.1 - 0.075 13.0 0.0 0.075 13.0 0.0 2.5 3 0 0 3 3 3 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein AAA_23 PF13476.6 ADV21347.1 - 7.8 6.9 9.7 15 6.0 2.4 3.0 3 0 0 3 3 3 0 AAA domain Not1 PF04054.15 ADV21348.1 - 5.2e-111 371.1 0.0 1e-110 370.1 0.0 1.5 1 0 0 1 1 1 1 CCR4-Not complex component, Not1 CNOT1_CAF1_bind PF16415.5 ADV21348.1 - 1e-81 273.6 1.0 2.2e-80 269.3 0.1 3.2 4 0 0 4 4 4 1 CCR4-NOT transcription complex subunit 1 CAF1-binding domain DUF3819 PF12842.7 ADV21348.1 - 2.7e-52 176.6 1.8 2.7e-52 176.6 1.8 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF3819) CNOT1_TTP_bind PF16417.5 ADV21348.1 - 1.9e-46 157.7 0.0 4.3e-46 156.5 0.0 1.5 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 TTP binding domain CNOT1_HEAT PF16418.5 ADV21348.1 - 3.2e-21 76.0 0.0 9e-21 74.5 0.0 1.8 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 HEAT repeat Acetyltransf_11 PF13720.6 ADV21348.1 - 0.037 14.5 0.1 0.14 12.6 0.1 2.0 1 0 0 1 1 1 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 PAP2 PF01569.21 ADV21350.1 - 1.4e-11 44.3 6.6 3.1e-11 43.2 6.0 1.9 1 1 0 1 1 1 1 PAP2 superfamily Ribosomal_L37e PF01907.19 ADV21351.1 - 1e-26 92.8 8.3 1.7e-26 92.1 8.3 1.4 1 0 0 1 1 1 1 Ribosomal protein L37e DZR PF12773.7 ADV21351.1 - 0.013 15.5 1.2 0.02 14.9 1.2 1.3 1 0 0 1 1 1 0 Double zinc ribbon C1_1 PF00130.22 ADV21351.1 - 0.025 14.5 3.0 0.039 13.8 3.0 1.3 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) LIM PF00412.22 ADV21351.1 - 0.026 14.7 2.2 0.039 14.2 2.2 1.3 1 0 0 1 1 1 0 LIM domain HypA PF01155.19 ADV21351.1 - 0.042 13.9 0.8 0.059 13.4 0.8 1.2 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-RING_5 PF14634.6 ADV21351.1 - 0.064 13.2 3.6 0.097 12.6 3.6 1.3 1 0 0 1 1 1 0 zinc-RING finger domain DNA_RNApol_7kD PF03604.13 ADV21351.1 - 0.093 12.4 3.2 0.74 9.6 0.6 2.2 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit CDC24_OB3 PF17244.2 ADV21351.1 - 0.12 12.1 0.6 0.13 11.9 0.6 1.1 1 0 0 1 1 1 0 Cell division control protein 24, OB domain 3 zinc_ribbon_2 PF13240.6 ADV21351.1 - 0.18 11.6 2.5 11 5.9 0.1 2.2 2 0 0 2 2 2 0 zinc-ribbon domain Rubredoxin_2 PF18073.1 ADV21351.1 - 0.22 11.3 2.7 4.4 7.1 0.1 2.3 2 0 0 2 2 2 0 Rubredoxin metal binding domain DUF2688 PF10892.8 ADV21351.1 - 0.6 9.6 4.2 13 5.3 2.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2688) zf-C3HC4_2 PF13923.6 ADV21351.1 - 0.7 9.8 4.8 1.1 9.2 4.8 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-HYPF PF07503.12 ADV21351.1 - 2.6 7.9 8.0 3.6 7.4 4.0 2.7 2 1 1 3 3 3 0 HypF finger TFIIF_alpha PF05793.12 ADV21352.1 - 2.1e-08 33.3 33.6 2.1e-08 33.3 33.6 3.6 3 2 1 4 4 4 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) FAM220 PF15487.6 ADV21352.1 - 3.8 7.1 15.1 1.8 8.1 10.0 2.4 2 0 0 2 2 2 0 FAM220 family Nop14 PF04147.12 ADV21352.1 - 6.9 4.7 32.9 9.6 4.3 32.9 1.1 1 0 0 1 1 1 0 Nop14-like family Fungal_trans PF04082.18 ADV21353.1 - 3e-11 42.9 0.0 4.4e-11 42.3 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ADV21353.1 - 2.8e-06 27.3 7.0 4.2e-06 26.8 7.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MRC1 PF09444.10 ADV21355.1 - 2.5e-22 80.0 25.4 2.5e-22 80.0 25.4 7.0 5 2 1 6 6 6 1 MRC1-like domain PIG-L PF02585.17 ADV21356.1 - 3.7e-25 89.0 0.0 5.4e-25 88.5 0.0 1.2 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase Med9 PF07544.13 ADV21357.1 - 0.0032 17.5 0.2 0.0046 17.0 0.2 1.2 1 0 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 DUF521 PF04412.13 ADV21357.1 - 0.11 11.1 0.1 0.14 10.8 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF521) Dynamitin PF04912.14 ADV21359.1 - 9.2e-75 252.4 0.1 1.1e-74 252.1 0.1 1.1 1 0 0 1 1 1 1 Dynamitin Baculo_PEP_C PF04513.12 ADV21359.1 - 0.052 13.6 0.9 0.42 10.7 0.2 2.5 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus TBCA PF02970.16 ADV21359.1 - 0.052 13.9 0.6 0.27 11.6 0.3 2.3 2 0 0 2 2 2 0 Tubulin binding cofactor A TPR_MLP1_2 PF07926.12 ADV21359.1 - 0.058 13.5 5.5 0.082 13.0 2.5 2.3 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein Fib_alpha PF08702.10 ADV21359.1 - 0.069 13.3 0.1 0.18 12.0 0.1 1.7 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family EzrA PF06160.12 ADV21359.1 - 0.073 11.2 0.4 0.12 10.5 0.4 1.2 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA Seryl_tRNA_N PF02403.22 ADV21359.1 - 0.1 12.8 4.6 0.21 11.8 3.0 2.2 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain BLOC1_2 PF10046.9 ADV21359.1 - 0.19 12.0 4.0 3.9 7.8 0.5 3.3 3 1 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Noelin-1 PF12308.8 ADV21359.1 - 0.23 11.4 0.5 2.1 8.4 0.1 2.4 1 1 1 2 2 2 0 Neurogenesis glycoprotein Prefoldin_2 PF01920.20 ADV21359.1 - 0.25 11.3 3.4 17 5.4 3.1 3.2 3 1 0 3 3 3 0 Prefoldin subunit ABC_tran_CTD PF16326.5 ADV21359.1 - 1 9.6 8.4 2.1 8.6 0.1 4.3 5 0 0 5 5 5 0 ABC transporter C-terminal domain RNase_T PF00929.24 ADV21360.1 - 1.4e-05 25.7 0.0 2.4e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 Exonuclease EloA-BP1 PF15870.5 ADV21360.1 - 0.072 13.3 0.1 1.3 9.2 0.0 2.3 1 1 1 2 2 2 0 ElonginA binding-protein 1 TrkH PF02386.16 ADV21361.1 - 2.8e-58 197.6 20.0 1.1e-42 146.1 5.2 3.1 3 0 0 3 3 3 3 Cation transport protein CLTH PF10607.9 ADV21362.1 - 3.2e-40 137.4 0.0 6e-40 136.5 0.0 1.4 2 0 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 ADV21362.1 - 1.7e-08 34.1 0.1 1.7e-08 34.1 0.1 2.6 3 0 0 3 3 3 1 LisH Rad60-SLD PF11976.8 ADV21364.1 - 1.6e-22 79.1 0.5 1.9e-22 78.9 0.5 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 ADV21364.1 - 4.3e-13 48.8 0.2 5.5e-13 48.5 0.2 1.1 1 0 0 1 1 1 1 Ubiquitin family Motile_Sperm PF00635.26 ADV21364.1 - 0.02 14.7 1.1 0.027 14.3 1.1 1.2 1 0 0 1 1 1 0 MSP (Major sperm protein) domain DUF3247 PF11607.8 ADV21364.1 - 0.13 12.5 0.0 0.19 12.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3247) MFS_1 PF07690.16 ADV21365.1 - 8e-35 120.4 35.5 8e-35 120.4 35.5 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ADV21365.1 - 7.8e-11 41.5 7.7 7.8e-11 41.5 7.7 2.5 2 1 1 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.13 ADV21365.1 - 7.9e-05 21.3 2.8 7.9e-05 21.3 2.8 2.1 2 0 0 2 2 2 2 Fungal trichothecene efflux pump (TRI12) Ribosomal_L23eN PF03939.13 ADV21366.1 - 1e-22 80.0 9.3 1e-22 80.0 9.3 1.9 2 0 0 2 2 2 1 Ribosomal protein L23, N-terminal domain Ribosomal_L23 PF00276.20 ADV21366.1 - 1.1e-15 57.7 4.9 1.9e-15 57.0 2.1 2.5 2 1 0 2 2 2 1 Ribosomal protein L23 TusA PF01206.17 ADV21366.1 - 0.13 12.1 0.3 0.28 11.0 0.1 1.6 2 0 0 2 2 2 0 Sulfurtransferase TusA zf-C2H2_jaz PF12171.8 ADV21367.1 - 2.9e-09 37.0 5.8 4.3e-09 36.4 5.8 1.3 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 ADV21367.1 - 0.0015 18.8 0.3 0.0027 18.0 0.3 1.4 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 ADV21367.1 - 0.004 17.5 4.9 0.0066 16.8 4.9 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type Tmemb_cc2 PF10267.9 ADV21368.1 - 0.059 12.5 0.3 0.092 11.9 0.3 1.2 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein Pox_F17 PF04767.12 ADV21368.1 - 9.6 6.8 6.5 11 6.7 0.5 2.9 2 0 0 2 2 2 0 DNA-binding 11 kDa phosphoprotein Zn_clus PF00172.18 ADV21369.1 - 0.00024 21.2 9.0 0.00042 20.4 9.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 ADV21369.1 - 0.011 14.7 0.7 0.018 14.1 0.0 1.6 2 0 0 2 2 2 0 Fungal specific transcription factor domain MFS_1 PF07690.16 ADV21370.1 - 1.3e-40 139.5 45.8 1.3e-40 139.5 45.8 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ADV21370.1 - 1.2e-05 24.4 13.7 1.2e-05 24.4 13.7 2.2 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_1 PF07690.16 ADV21371.1 - 1.1e-36 126.5 45.5 1.1e-36 126.5 45.5 1.6 1 1 1 2 2 2 2 Major Facilitator Superfamily Inv-AAD PF18785.1 ADV21372.1 - 2.4e-17 63.0 0.0 1.2e-12 47.8 0.1 2.5 2 0 0 2 2 2 2 Invertebrate-AID/APOBEC-deaminase ASH PF15780.5 ADV21372.1 - 8.2e-09 35.6 6.0 0.011 15.9 0.1 7.0 7 0 0 7 7 7 2 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin PapD-like PF14874.6 ADV21372.1 - 8.9e-07 29.0 0.2 1.7 8.9 0.0 4.5 4 0 0 4 4 4 3 Flagellar-associated PapD-like dCMP_cyt_deam_1 PF00383.23 ADV21372.1 - 0.0011 18.8 0.0 0.0038 17.1 0.0 1.9 1 1 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region DUF1573 PF07610.11 ADV21372.1 - 0.077 13.0 1.9 2.1e+02 2.0 0.0 5.2 6 0 0 6 6 6 0 Protein of unknown function (DUF1573) Cornichon PF03311.14 ADV21373.1 - 1e-52 177.6 9.8 1.2e-52 177.4 9.8 1.0 1 0 0 1 1 1 1 Cornichon protein CTP_synth_N PF06418.14 ADV21374.1 - 8.2e-121 402.3 0.1 1.1e-120 401.9 0.1 1.1 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.28 ADV21374.1 - 1.2e-51 175.2 0.0 2e-51 174.5 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I RVT_connect PF06815.13 ADV21374.1 - 0.049 13.9 0.2 0.19 12.0 0.0 1.9 2 0 0 2 2 2 0 Reverse transcriptase connection domain Peptidase_C26 PF07722.13 ADV21374.1 - 0.081 12.7 0.1 0.63 9.8 0.0 2.2 2 0 0 2 2 2 0 Peptidase C26 CbiA PF01656.23 ADV21374.1 - 0.17 11.9 0.0 0.32 11.1 0.0 1.6 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain HMGL-like PF00682.19 ADV21375.1 - 1.6e-40 139.4 0.0 6.8e-31 107.8 0.0 2.0 2 0 0 2 2 2 2 HMGL-like HIT PF01230.23 ADV21376.1 - 3e-23 82.4 0.3 4.6e-23 81.8 0.3 1.3 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 ADV21376.1 - 3e-13 50.3 0.0 4.2e-13 49.8 0.0 1.2 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 ADV21376.1 - 6.1e-06 26.1 0.1 8.6e-06 25.6 0.1 1.3 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 WD40 PF00400.32 ADV21377.1 - 2.6e-18 66.0 10.3 4.1e-06 27.4 0.1 6.2 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV21377.1 - 8.1e-09 35.7 0.0 0.19 12.1 0.0 5.8 4 1 1 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain CDC27 PF09507.10 ADV21379.1 - 2.8e-35 122.6 10.0 1e-23 84.5 0.0 2.1 1 1 1 2 2 2 2 DNA polymerase subunit Cdc27 Per1 PF04080.13 ADV21380.1 - 7.7e-84 281.4 7.3 9.1e-84 281.2 7.3 1.0 1 0 0 1 1 1 1 Per1-like family DEAD PF00270.29 ADV21381.1 - 1.9e-22 79.8 0.0 3.3e-22 79.1 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ADV21381.1 - 6e-11 42.7 0.0 2.8e-10 40.5 0.0 2.0 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 ADV21381.1 - 0.0034 17.4 0.0 0.0058 16.7 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit LigD_N PF13298.6 ADV21382.1 - 7e-19 68.1 0.2 1.2e-18 67.3 0.2 1.4 1 0 0 1 1 1 1 DNA polymerase Ligase (LigD) Jnk-SapK_ap_N PF09744.9 ADV21382.1 - 0.075 13.3 0.5 13 6.0 0.3 2.1 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 Chitin_synth_1 PF01644.17 ADV21383.1 - 1.5e-76 255.9 0.0 2.2e-76 255.3 0.0 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 ADV21383.1 - 1.4e-29 101.9 0.3 2.8e-29 100.9 0.3 1.5 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 ADV21383.1 - 1.6e-28 99.6 1.1 3.3e-22 78.8 0.0 2.1 2 0 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 ADV21383.1 - 1.3e-07 31.8 0.5 1.3e-07 31.8 0.5 2.9 3 0 0 3 3 3 1 Glycosyl transferase family group 2 LOR PF04525.12 ADV21384.1 - 1.2e-25 90.2 0.0 1.4e-25 90.0 0.0 1.0 1 0 0 1 1 1 1 LURP-one-related zf-MYND PF01753.18 ADV21385.1 - 2.1 8.5 4.9 4.4 7.5 4.9 1.5 1 0 0 1 1 1 0 MYND finger HNH_2 PF13391.6 ADV21386.1 - 8.8e-07 29.0 0.0 9.6e-06 25.6 0.0 2.3 2 1 0 2 2 2 1 HNH endonuclease UCH PF00443.29 ADV21388.1 - 8.4e-07 28.7 0.0 1.8e-06 27.7 0.0 1.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RAP80_UIM PF18282.1 ADV21388.1 - 0.012 15.4 1.2 1.5 8.6 0.2 2.7 2 0 0 2 2 2 0 RAP80 N-terminal ubiquitin interaction motif UIM PF02809.20 ADV21388.1 - 1.9 8.6 5.3 16 5.7 0.2 3.3 3 0 0 3 3 3 0 Ubiquitin interaction motif CoiA PF06054.11 ADV21389.1 - 0.042 13.0 0.5 0.059 12.5 0.5 1.3 1 0 0 1 1 1 0 Competence protein CoiA-like family Inhibitor_I9 PF05922.16 ADV21389.1 - 0.053 14.2 2.3 1.8 9.3 0.4 2.4 2 0 0 2 2 2 0 Peptidase inhibitor I9 HSP70 PF00012.20 ADV21389.1 - 0.34 9.0 5.0 0.44 8.7 5.0 1.1 1 0 0 1 1 1 0 Hsp70 protein SYF2 PF08231.12 ADV21389.1 - 0.39 11.1 11.9 0.27 11.6 9.2 1.9 1 1 1 2 2 2 0 SYF2 splicing factor AATF-Che1 PF13339.6 ADV21389.1 - 1.2 9.9 7.7 1.4 9.6 6.3 1.9 1 1 1 2 2 2 0 Apoptosis antagonizing transcription factor Cupin_2 PF07883.11 ADV21391.1 - 2e-08 33.8 0.2 3.4e-08 33.1 0.2 1.3 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 ADV21391.1 - 8.6e-06 25.4 0.2 1.3e-05 24.9 0.2 1.2 1 0 0 1 1 1 1 Cupin Cupin_6 PF12852.7 ADV21391.1 - 0.039 13.7 0.0 0.044 13.5 0.0 1.1 1 0 0 1 1 1 0 Cupin Cupin_1 PF00190.22 ADV21392.1 - 1.8e-08 34.1 0.1 2.5e-08 33.6 0.1 1.2 1 0 0 1 1 1 1 Cupin Cupin_2 PF07883.11 ADV21392.1 - 1.9e-08 33.9 0.5 3.4e-08 33.1 0.5 1.4 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 ADV21392.1 - 0.0015 18.4 0.0 0.0022 17.9 0.0 1.2 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_6 PF12852.7 ADV21392.1 - 0.0016 18.2 0.1 0.002 17.9 0.1 1.1 1 0 0 1 1 1 1 Cupin ARD PF03079.14 ADV21392.1 - 0.18 11.9 0.0 0.26 11.4 0.0 1.2 1 0 0 1 1 1 0 ARD/ARD' family ELO PF01151.18 ADV21393.1 - 2.1e-62 210.9 17.3 2.5e-62 210.7 17.3 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family Phosphodiest PF01663.22 ADV21394.1 - 7.1e-77 259.4 0.2 8.8e-77 259.1 0.2 1.1 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 ADV21394.1 - 0.0077 15.7 0.0 0.46 9.8 0.0 2.3 2 0 0 2 2 2 2 Sulfatase Methyltransf_11 PF08241.12 ADV21395.1 - 2.9e-07 31.1 0.1 4.3e-05 24.1 0.1 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ADV21395.1 - 8.1e-07 29.0 0.0 1.5e-06 28.1 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ADV21395.1 - 1.1e-06 28.5 0.0 0.0044 16.8 0.1 2.1 1 1 1 2 2 2 2 Methyltransferase domain Methyltransf_25 PF13649.6 ADV21395.1 - 3.1e-06 27.8 0.1 0.096 13.4 0.0 2.3 1 1 1 2 2 2 2 Methyltransferase domain Ubie_methyltran PF01209.18 ADV21395.1 - 5.8e-06 25.8 0.0 0.0011 18.4 0.0 2.1 1 1 1 2 2 2 2 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 ADV21395.1 - 1e-05 26.2 0.1 0.0072 17.1 0.0 2.3 1 1 1 2 2 2 2 Methyltransferase domain MTS PF05175.14 ADV21395.1 - 8.4e-05 22.2 0.0 0.00012 21.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.19 ADV21395.1 - 0.0033 17.2 0.0 0.0062 16.3 0.0 1.5 1 1 1 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) N6_Mtase PF02384.16 ADV21395.1 - 0.036 13.3 0.0 0.054 12.8 0.0 1.3 1 0 0 1 1 1 0 N-6 DNA Methylase MetW PF07021.12 ADV21395.1 - 0.056 13.0 0.0 0.87 9.2 0.0 2.0 1 1 1 2 2 2 0 Methionine biosynthesis protein MetW HU-CCDC81_euk_2 PF18289.1 ADV21395.1 - 0.096 12.9 0.0 0.16 12.1 0.0 1.3 1 0 0 1 1 1 0 CCDC81 eukaryotic HU domain 2 CMAS PF02353.20 ADV21395.1 - 0.1 11.9 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase DREV PF05219.12 ADV21395.1 - 0.17 11.0 0.0 0.18 10.8 0.0 1.1 1 0 0 1 1 1 0 DREV methyltransferase Methyltransf_7 PF03492.15 ADV21395.1 - 0.27 10.4 0.4 3.8 6.6 0.1 2.2 1 1 1 2 2 2 0 SAM dependent carboxyl methyltransferase Nop16 PF09420.10 ADV21396.1 - 1.3e-57 195.2 7.6 1.5e-57 195.0 7.6 1.0 1 0 0 1 1 1 1 Ribosome biogenesis protein Nop16 PHD PF00628.29 ADV21397.1 - 3.9e-08 33.0 9.5 7.5e-08 32.1 9.5 1.5 1 0 0 1 1 1 1 PHD-finger Prok-RING_1 PF14446.6 ADV21397.1 - 0.00036 20.4 2.1 0.00036 20.4 2.1 1.9 2 0 0 2 2 2 1 Prokaryotic RING finger family 1 TFIIA PF03153.13 ADV21397.1 - 0.0044 17.1 16.9 0.0044 17.1 16.9 3.2 3 0 0 3 3 3 1 Transcription factor IIA, alpha/beta subunit zf-HC5HC2H PF13771.6 ADV21397.1 - 0.069 13.4 1.7 0.2 11.9 1.7 1.8 1 0 0 1 1 1 0 PHD-like zinc-binding domain PHD_4 PF16866.5 ADV21397.1 - 0.98 9.6 6.6 4.1 7.6 6.6 2.2 1 0 0 1 1 1 0 PHD-finger Zf_RING PF16744.5 ADV21397.1 - 2.4 8.3 6.6 7.7 6.7 6.6 1.8 1 0 0 1 1 1 0 KIAA1045 RING finger C1_1 PF00130.22 ADV21397.1 - 4.1 7.4 6.8 0.58 10.1 1.7 2.0 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) CsbD PF05532.12 ADV21398.1 - 6.1e-08 32.4 10.3 8.4e-06 25.6 2.7 3.1 1 1 2 3 3 3 2 CsbD-like HSP9_HSP12 PF04119.12 ADV21398.1 - 0.045 14.2 0.2 0.11 12.9 0.2 1.7 1 1 0 1 1 1 0 Heat shock protein 9/12 zf-CCHC PF00098.23 ADV21399.1 - 0.0095 16.0 2.5 0.0095 16.0 2.5 2.1 2 0 0 2 2 2 1 Zinc knuckle DUF733 PF05306.11 ADV21399.1 - 0.13 12.6 0.0 0.33 11.3 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF733) zf-CCHC_5 PF14787.6 ADV21399.1 - 0.2 11.4 1.0 0.51 10.1 1.0 1.6 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger TANGO2 PF05742.12 ADV21400.1 - 5.3e-50 170.8 0.0 5.6e-36 124.9 0.0 2.0 2 0 0 2 2 2 2 Transport and Golgi organisation 2 PP2C PF00481.21 ADV21401.1 - 4.8e-69 232.9 0.0 6.2e-68 229.2 0.0 2.0 1 1 0 1 1 1 1 Protein phosphatase 2C DAO PF01266.24 ADV21402.1 - 2.2e-26 93.3 0.1 2.7e-26 93.0 0.1 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase SKI PF01202.22 ADV21403.1 - 1.8e-07 31.4 0.0 4.3e-06 26.9 0.0 2.6 1 1 1 2 2 2 1 Shikimate kinase Cytidylate_kin PF02224.18 ADV21403.1 - 2e-05 24.5 0.0 2.6e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 Cytidylate kinase AAA_33 PF13671.6 ADV21403.1 - 0.00012 22.3 0.0 0.0033 17.6 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ADV21403.1 - 0.00041 20.9 0.0 0.0033 18.0 0.0 2.1 1 1 0 1 1 1 1 AAA domain ThuA PF06283.11 ADV21403.1 - 0.0011 19.3 0.0 0.0014 18.9 0.0 1.1 1 0 0 1 1 1 1 Trehalose utilisation AAA_25 PF13481.6 ADV21403.1 - 0.0019 17.8 0.0 0.0039 16.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ADV21403.1 - 0.0083 16.5 0.0 0.011 16.2 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 ADV21403.1 - 0.034 14.6 0.0 0.064 13.7 0.0 1.5 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 ADV21403.1 - 0.11 12.8 0.0 0.18 12.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain Cytidylate_kin2 PF13189.6 ADV21403.1 - 0.13 12.3 0.0 0.21 11.7 0.0 1.4 1 0 0 1 1 1 0 Cytidylate kinase-like family Solute_trans_a PF03619.16 ADV21404.1 - 6.9e-76 255.3 20.8 9e-76 254.9 20.8 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha PGA2 PF07543.12 ADV21404.1 - 2.2 8.3 3.8 14 5.7 0.3 2.2 2 0 0 2 2 2 0 Protein trafficking PGA2 Methyltransf_23 PF13489.6 ADV21405.1 - 0.00093 19.1 0.0 0.0018 18.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Asp_protease PF09668.10 ADV21407.1 - 2.6e-63 211.4 0.0 4e-63 210.7 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 ADV21407.1 - 9.1e-23 80.6 0.0 2.6e-22 79.2 0.0 1.8 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 ADV21407.1 - 3.5e-11 43.6 0.0 9.7e-11 42.2 0.0 1.8 1 0 0 1 1 1 1 Aspartyl protease UBA PF00627.31 ADV21407.1 - 7.5e-06 25.7 0.0 1.6e-05 24.7 0.0 1.6 1 0 0 1 1 1 1 UBA/TS-N domain RVP_2 PF08284.11 ADV21407.1 - 0.00023 20.9 0.0 0.00045 20.0 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease RVP PF00077.20 ADV21407.1 - 0.00087 19.6 0.0 0.0021 18.4 0.0 1.7 1 0 0 1 1 1 1 Retroviral aspartyl protease UBA_4 PF14555.6 ADV21407.1 - 0.0015 18.3 0.0 0.0031 17.3 0.0 1.5 1 0 0 1 1 1 1 UBA-like domain ANAPC4_WD40 PF12894.7 ADV21408.1 - 2e-11 44.0 0.9 0.00097 19.4 0.1 7.0 4 3 2 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ADV21408.1 - 0.00018 22.2 12.7 0.0033 18.2 0.0 6.3 8 0 0 8 8 8 1 WD domain, G-beta repeat PD40 PF07676.12 ADV21408.1 - 0.23 11.5 4.3 1.8 8.6 0.0 3.8 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Methyltransf_28 PF02636.17 ADV21409.1 - 3.3e-70 236.7 0.0 4.1e-70 236.4 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Fra10Ac1 PF09725.9 ADV21410.1 - 1.6e-38 131.6 0.1 2.4e-38 131.0 0.1 1.3 1 0 0 1 1 1 1 Folate-sensitive fragile site protein Fra10Ac1 RRM_1 PF00076.22 ADV21411.1 - 7.6e-10 38.5 0.0 1.5e-09 37.5 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PWI PF01480.17 ADV21411.1 - 4.6e-09 36.5 1.2 7.1e-09 35.9 0.2 1.9 2 0 0 2 2 2 1 PWI domain ATP-synt_D PF01813.17 ADV21412.1 - 3.1e-70 236.0 0.6 3.9e-70 235.7 0.6 1.1 1 0 0 1 1 1 1 ATP synthase subunit D Pkinase PF00069.25 ADV21413.1 - 3.9e-61 206.7 0.0 2.6e-40 138.4 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ADV21413.1 - 8.7e-26 90.7 0.0 2.9e-21 75.9 0.0 2.6 3 0 0 3 3 3 2 Protein tyrosine kinase Response_reg PF00072.24 ADV21413.1 - 7.4e-12 45.4 0.0 2.1e-11 43.9 0.0 1.9 1 0 0 1 1 1 1 Response regulator receiver domain Kinase-like PF14531.6 ADV21413.1 - 2.7e-07 30.2 0.4 0.0009 18.6 0.0 2.7 3 0 0 3 3 3 2 Kinase-like PAS_9 PF13426.7 ADV21413.1 - 2.5e-06 27.7 0.0 7.8e-06 26.1 0.0 1.9 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 ADV21413.1 - 0.0021 18.0 0.0 0.0056 16.7 0.0 1.7 1 0 0 1 1 1 1 PAS fold APH PF01636.23 ADV21413.1 - 0.0038 17.2 0.0 0.088 12.7 0.1 2.4 1 1 1 2 2 2 1 Phosphotransferase enzyme family PAS_3 PF08447.12 ADV21413.1 - 0.0089 16.3 0.0 0.021 15.1 0.0 1.6 1 0 0 1 1 1 1 PAS fold Seadorna_VP7 PF07387.11 ADV21413.1 - 0.035 13.1 0.0 0.059 12.4 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Haspin_kinase PF12330.8 ADV21413.1 - 0.084 11.8 0.0 0.15 11.0 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain DUF2007 PF09413.10 ADV21413.1 - 0.12 12.5 0.0 0.25 11.5 0.0 1.5 1 0 0 1 1 1 0 Putative prokaryotic signal transducing protein Serglycin PF04360.12 ADV21413.1 - 0.81 9.6 5.7 1.7 8.6 0.3 3.1 3 0 0 3 3 3 0 Serglycin Gtr1_RagA PF04670.12 ADV21414.1 - 4e-35 121.3 0.5 6.4e-35 120.6 0.5 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.21 ADV21414.1 - 0.00077 19.0 0.0 0.0012 18.3 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ADV21414.1 - 0.00099 19.2 0.0 0.002 18.2 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Ras PF00071.22 ADV21414.1 - 0.0014 18.3 0.0 0.0021 17.6 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ADV21414.1 - 0.0017 18.5 0.0 0.0037 17.5 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase GEN1_C PF18380.1 ADV21414.1 - 0.0032 18.4 3.7 0.0085 17.0 3.7 1.8 1 0 0 1 1 1 1 Holliday junction resolvase Gen1 C-terminal domain CDC45 PF02724.14 ADV21414.1 - 0.0087 14.4 5.6 0.012 13.9 5.6 1.1 1 0 0 1 1 1 1 CDC45-like protein Sedlin_N PF04628.13 ADV21414.1 - 0.031 14.4 0.1 0.11 12.6 0.0 1.9 2 0 0 2 2 2 0 Sedlin, N-terminal conserved region PPP4R2 PF09184.11 ADV21414.1 - 0.047 13.3 4.5 0.066 12.8 4.5 1.2 1 0 0 1 1 1 0 PPP4R2 AAA_16 PF13191.6 ADV21414.1 - 0.074 13.4 0.1 11 6.4 0.0 2.7 2 1 1 3 3 3 0 AAA ATPase domain Voldacs PF03517.13 ADV21414.1 - 0.15 12.2 5.1 0.29 11.2 5.1 1.5 1 0 0 1 1 1 0 Regulator of volume decrease after cellular swelling NOA36 PF06524.12 ADV21414.1 - 0.56 9.5 12.8 0.82 8.9 12.8 1.2 1 0 0 1 1 1 0 NOA36 protein CobT PF06213.12 ADV21414.1 - 2.7 7.3 9.7 5.2 6.4 9.7 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DNA_pol_phi PF04931.13 ADV21414.1 - 4.1 5.4 15.0 6.1 4.8 15.0 1.2 1 0 0 1 1 1 0 DNA polymerase phi Nop14 PF04147.12 ADV21414.1 - 4.3 5.4 10.5 5.8 5.0 10.5 1.1 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 ADV21414.1 - 8.3 5.7 12.1 4 6.8 10.1 1.4 2 0 0 2 2 2 0 SDA1 Sigma70_ner PF04546.13 ADV21414.1 - 9.3 6.1 11.0 2.6 7.9 8.0 1.5 2 0 0 2 2 2 0 Sigma-70, non-essential region Mtr2 PF10429.9 ADV21415.1 - 2.9e-08 33.8 0.0 4.1e-08 33.3 0.0 1.2 1 0 0 1 1 1 1 Nuclear pore RNA shuttling protein Mtr2 NTF2 PF02136.20 ADV21415.1 - 4.9e-07 30.3 0.0 1.4e-06 28.9 0.0 1.7 1 1 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain AMP-binding PF00501.28 ADV21416.1 - 1.3e-83 281.0 0.0 4.1e-83 279.3 0.0 1.7 2 0 0 2 2 2 1 AMP-binding enzyme DnaJ PF00226.31 ADV21417.1 - 8.2e-15 54.7 1.7 1.6e-14 53.8 1.7 1.5 1 0 0 1 1 1 1 DnaJ domain Usp PF00582.26 ADV21417.1 - 0.52 10.8 5.1 2.6 8.5 2.4 2.2 1 1 1 2 2 2 0 Universal stress protein family DcpS_C PF11969.8 ADV21418.1 - 1.8e-16 60.6 0.6 2.4e-16 60.2 0.6 1.1 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding HIT PF01230.23 ADV21418.1 - 7.8e-07 29.7 7.2 9e-06 26.3 7.2 2.1 1 1 0 1 1 1 1 HIT domain OPT PF03169.15 ADV21419.1 - 3.8e-189 630.3 56.4 4.4e-189 630.1 56.4 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF3506 PF12014.8 ADV21419.1 - 0.15 12.0 0.0 0.28 11.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3506) Syja_N PF02383.18 ADV21420.1 - 1.5e-62 211.8 0.0 2.2e-62 211.2 0.0 1.2 1 0 0 1 1 1 1 SacI homology domain Exo_endo_phos PF03372.23 ADV21420.1 - 1.9e-06 27.6 0.0 3.3e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Cys_Met_Meta_PP PF01053.20 ADV21421.1 - 7.7e-25 87.2 0.0 1e-24 86.8 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 ADV21421.1 - 0.026 13.7 0.0 0.045 12.9 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class I and II Pep3_Vps18 PF05131.14 ADV21422.1 - 2.1e-43 147.7 0.0 3.9e-43 146.8 0.0 1.5 1 0 0 1 1 1 1 Pep3/Vps18/deep orange family Clathrin PF00637.20 ADV21422.1 - 7.7e-08 32.3 6.4 2.1e-06 27.6 0.1 2.9 3 0 0 3 3 3 2 Region in Clathrin and VPS Vps39_2 PF10367.9 ADV21422.1 - 0.0075 16.7 0.2 0.02 15.3 0.0 1.8 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 2 Zn_ribbon_17 PF17120.5 ADV21422.1 - 0.0087 15.7 0.7 0.023 14.3 0.7 1.7 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-C3HC4_2 PF13923.6 ADV21422.1 - 0.009 15.8 2.0 0.009 15.8 2.0 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ADV21422.1 - 0.027 14.4 0.7 0.027 14.4 0.7 2.0 2 0 0 2 2 2 0 zinc-RING finger domain zf-RING_11 PF17123.5 ADV21422.1 - 0.037 13.8 2.9 0.079 12.7 2.9 1.6 1 0 0 1 1 1 0 RING-like zinc finger zf-C3HC4 PF00097.25 ADV21422.1 - 0.42 10.5 3.6 0.24 11.3 0.5 2.1 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ADV21422.1 - 0.47 10.8 7.4 0.05 13.9 0.9 2.5 3 0 0 3 3 3 0 Ring finger domain Sugar_tr PF00083.24 ADV21423.1 - 1.1e-113 380.6 20.8 1.2e-113 380.4 20.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ADV21423.1 - 3.3e-20 72.3 44.2 5e-18 65.1 13.9 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 ADV21423.1 - 8 4.6 19.0 0.23 9.7 6.9 2.9 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family PhaP_Bmeg PF09602.10 ADV21424.1 - 0.0046 16.9 0.5 0.013 15.5 0.5 1.8 1 0 0 1 1 1 1 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) SlyX PF04102.12 ADV21424.1 - 6.6 7.4 6.2 13 6.5 0.9 3.4 3 1 1 4 4 4 0 SlyX COG5 PF10392.9 ADV21425.1 - 1.9e-45 154.3 6.5 6.6e-45 152.5 4.7 2.5 2 0 0 2 2 2 1 Golgi transport complex subunit 5 LINES_C PF14695.6 ADV21425.1 - 0.013 14.9 0.0 0.038 13.4 0.0 1.8 1 0 0 1 1 1 0 Lines C-terminus FtsK_gamma PF09397.10 ADV21425.1 - 0.089 12.6 0.0 0.41 10.5 0.0 2.2 1 0 0 1 1 1 0 Ftsk gamma domain PUF PF00806.19 ADV21426.1 - 4e-07 29.4 0.0 0.0082 15.8 0.0 4.8 5 0 0 5 5 5 2 Pumilio-family RNA binding repeat DUF3426 PF11906.8 ADV21428.1 - 0.0092 16.2 0.1 0.011 15.9 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3426) HEPN_STY4199 PF18729.1 ADV21428.1 - 0.0093 15.2 0.2 0.011 14.9 0.2 1.2 1 0 0 1 1 1 1 STY4199-like HEPN WD40 PF00400.32 ADV21429.1 - 8.6e-14 51.7 7.0 1.4e-06 28.9 0.1 6.3 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV21429.1 - 6.9e-09 35.9 0.1 0.016 15.5 0.1 5.6 4 2 3 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ADV21429.1 - 0.0015 18.4 0.0 0.67 9.8 0.0 2.9 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 ADV21429.1 - 0.026 13.1 0.0 1.3 7.4 0.0 2.9 3 1 1 4 4 4 0 Cytochrome D1 heme domain Coatomer_WDAD PF04053.14 ADV21429.1 - 0.032 13.3 0.0 0.062 12.3 0.0 1.4 1 0 0 1 1 1 0 Coatomer WD associated region PQQ_3 PF13570.6 ADV21429.1 - 0.059 13.9 0.2 0.39 11.3 0.0 2.5 2 0 0 2 2 2 0 PQQ-like domain Hira PF07569.11 ADV21429.1 - 0.16 11.7 0.3 37 3.9 0.0 3.2 2 1 1 3 3 3 0 TUP1-like enhancer of split DnaJ-X PF14308.6 ADV21430.1 - 5.7e-48 163.1 2.7 1.3e-47 162.0 2.7 1.6 1 0 0 1 1 1 1 X-domain of DnaJ-containing DnaJ PF00226.31 ADV21430.1 - 2.2e-25 88.6 1.5 2.2e-25 88.6 1.5 2.5 2 0 0 2 2 2 1 DnaJ domain ADD_DNMT3 PF17980.1 ADV21430.1 - 0.1 12.6 0.2 0.22 11.5 0.2 1.5 1 0 0 1 1 1 0 Cysteine rich ADD domain in DNMT3 zinc_ribbon_4 PF13717.6 ADV21430.1 - 0.14 12.1 2.8 0.61 10.1 2.8 2.1 1 1 0 1 1 1 0 zinc-ribbon domain TFIIE_alpha PF02002.17 ADV21432.1 - 1.4e-08 34.6 1.2 3e-06 27.0 1.2 2.5 1 1 0 1 1 1 1 TFIIE alpha subunit TF_Zn_Ribbon PF08271.12 ADV21432.1 - 0.0028 17.1 0.2 0.0061 16.1 0.2 1.6 1 0 0 1 1 1 1 TFIIB zinc-binding HTH_9 PF08221.11 ADV21432.1 - 0.0055 16.8 0.1 0.036 14.2 0.0 2.2 2 0 0 2 2 2 1 RNA polymerase III subunit RPC82 helix-turn-helix domain HTH_24 PF13412.6 ADV21432.1 - 0.053 13.1 0.0 0.67 9.6 0.0 2.3 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding GFA PF04828.14 ADV21433.1 - 1.6e-08 34.8 0.3 4.8e-08 33.2 0.3 1.8 1 1 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme 60KD_IMP PF02096.20 ADV21434.1 - 1e-17 64.6 0.6 1.5e-10 41.2 0.0 2.5 2 1 0 2 2 2 2 60Kd inner membrane protein BESS PF02944.20 ADV21434.1 - 0.063 13.1 0.3 0.32 10.9 0.3 2.2 2 0 0 2 2 2 0 BESS motif HDV_ag PF01517.18 ADV21434.1 - 0.16 11.8 0.1 0.27 11.0 0.1 1.3 1 0 0 1 1 1 0 Hepatitis delta virus delta antigen Glyco_hydro_71 PF03659.14 ADV21435.1 - 6e-124 413.7 11.7 6e-124 413.7 11.7 2.1 2 0 0 2 2 2 1 Glycosyl hydrolase family 71 WSC PF01822.19 ADV21435.1 - 6.7e-35 119.1 25.2 1.9e-18 66.4 7.4 3.2 3 0 0 3 3 3 2 WSC domain Beta_elim_lyase PF01212.21 ADV21436.1 - 1.1e-69 234.9 0.0 1.5e-69 234.6 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 ADV21436.1 - 1.2e-06 28.0 0.0 3.2e-06 26.6 0.0 1.6 1 1 1 2 2 2 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 ADV21436.1 - 0.00012 20.7 0.0 0.00021 19.9 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 ADV21436.1 - 0.06 12.3 0.4 0.093 11.7 0.4 1.2 1 0 0 1 1 1 0 Aminotransferase class-V Aminotran_3 PF00202.21 ADV21437.1 - 1e-108 363.6 0.0 1.3e-108 363.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 ADV21437.1 - 0.0017 17.6 0.0 0.0034 16.6 0.0 1.4 1 1 0 1 1 1 1 Aminotransferase class I and II DUF963 PF06131.11 ADV21437.1 - 0.91 9.0 5.0 1.8 8.1 5.0 1.4 1 0 0 1 1 1 0 Schizosaccharomyces pombe repeat of unknown function (DUF963) GATase_6 PF13522.6 ADV21438.1 - 4.3e-14 52.9 0.0 8.8e-14 51.9 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 ADV21438.1 - 1.1e-08 35.0 0.0 2.1e-08 34.1 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain Pribosyltran PF00156.27 ADV21438.1 - 3.8e-08 33.0 0.1 6.8e-08 32.2 0.1 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain GATase_4 PF13230.6 ADV21438.1 - 0.00047 19.1 0.0 0.00092 18.2 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferases class-II UPRTase PF14681.6 ADV21438.1 - 0.054 12.9 0.0 0.14 11.6 0.0 1.6 2 0 0 2 2 2 0 Uracil phosphoribosyltransferase Med22 PF06179.12 ADV21439.1 - 5.7e-07 29.7 0.0 1.1e-06 28.8 0.0 1.4 1 0 0 1 1 1 1 Surfeit locus protein 5 subunit 22 of Mediator complex DUF842 PF05811.13 ADV21439.1 - 0.045 13.4 0.0 0.083 12.6 0.0 1.3 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF842) SAPS PF04499.15 ADV21439.1 - 0.21 10.3 2.9 0.25 10.1 2.9 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Rad51 PF08423.11 ADV21440.1 - 1.1e-05 24.8 0.0 2.5e-05 23.7 0.0 1.5 1 1 1 2 2 2 1 Rad51 AAA_25 PF13481.6 ADV21440.1 - 0.00048 19.7 0.1 0.00077 19.1 0.1 1.3 1 0 0 1 1 1 1 AAA domain RecA PF00154.21 ADV21440.1 - 0.085 12.3 0.0 0.16 11.4 0.0 1.4 1 0 0 1 1 1 0 recA bacterial DNA recombination protein AAA_14 PF13173.6 ADV21440.1 - 0.13 12.3 0.0 0.23 11.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain ADH_zinc_N_2 PF13602.6 ADV21441.1 - 2e-26 93.6 0.0 5.4e-26 92.2 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 ADV21441.1 - 1.6e-14 54.0 0.0 2.7e-14 53.2 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ADV21441.1 - 5.4e-11 42.3 0.3 1.8e-10 40.7 0.2 1.8 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ELFV_dehydrog PF00208.21 ADV21441.1 - 0.0046 16.7 0.1 0.014 15.1 0.1 1.7 2 0 0 2 2 2 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase AlaDh_PNT_C PF01262.21 ADV21441.1 - 0.05 12.9 2.2 0.086 12.1 2.2 1.4 1 1 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain CMAS PF02353.20 ADV21441.1 - 0.21 10.9 0.0 0.32 10.3 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase ECH_1 PF00378.20 ADV21442.1 - 1.3e-29 103.3 0.0 4.4e-27 95.0 0.0 2.1 2 0 0 2 2 2 2 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ADV21442.1 - 7e-06 25.8 0.0 9.7e-06 25.3 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase 2-Hacid_dh_C PF02826.19 ADV21443.1 - 1.2e-59 200.7 0.0 1.6e-59 200.3 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 ADV21443.1 - 2.5e-13 49.8 0.0 3e-13 49.6 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 ADV21443.1 - 1.7e-06 28.3 0.0 4e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.12 ADV21443.1 - 0.023 14.3 0.0 0.15 11.6 0.0 2.0 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain F420_oxidored PF03807.17 ADV21443.1 - 0.04 14.5 0.0 0.072 13.7 0.0 1.4 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent DUF4588 PF15251.6 ADV21445.1 - 9.2e-08 32.2 1.8 1.4e-07 31.5 1.8 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4588) Pex2_Pex12 PF04757.14 ADV21446.1 - 1.6e-37 129.3 8.1 2e-37 128.9 8.1 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-RING_UBOX PF13445.6 ADV21446.1 - 0.038 14.0 0.0 0.097 12.7 0.0 1.7 1 0 0 1 1 1 0 RING-type zinc-finger DUF3445 PF11927.8 ADV21446.1 - 0.11 12.1 0.0 0.17 11.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3445) zf-C3HC4_4 PF15227.6 ADV21446.1 - 0.13 12.5 0.1 0.24 11.6 0.1 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING CDC14 PF08045.11 ADV21447.1 - 3.5e-25 88.7 1.2 1e-19 70.8 0.2 2.3 2 0 0 2 2 2 2 Cell division control protein 14, SIN component TP_methylase PF00590.20 ADV21450.1 - 1.2e-43 149.5 0.5 1.2e-43 149.5 0.5 1.6 2 0 0 2 2 2 1 Tetrapyrrole (Corrin/Porphyrin) Methylases NAD_binding_7 PF13241.6 ADV21450.1 - 1.2e-12 48.2 0.0 2.3e-12 47.3 0.0 1.5 1 0 0 1 1 1 1 Putative NAD(P)-binding Sirohm_synth_C PF14823.6 ADV21450.1 - 3.8e-10 39.2 4.3 1.8e-06 27.5 1.3 2.5 2 0 0 2 2 2 2 Sirohaem biosynthesis protein C-terminal Sirohm_synth_M PF14824.6 ADV21450.1 - 5.2e-09 35.4 0.1 1e-08 34.5 0.1 1.5 1 0 0 1 1 1 1 Sirohaem biosynthesis protein central EBP PF05241.12 ADV21450.1 - 0.047 13.1 4.7 0.09 12.2 4.7 1.5 1 0 0 1 1 1 0 Emopamil binding protein MFS_1 PF07690.16 ADV21451.1 - 1.1e-27 96.9 28.7 1.1e-27 96.9 28.7 1.6 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2178 PF09946.9 ADV21451.1 - 0.14 12.4 2.2 0.59 10.3 0.0 3.2 3 1 1 4 4 4 0 Predicted membrane protein (DUF2178) Tubulin PF00091.25 ADV21452.1 - 3.1e-67 226.6 0.0 5e-67 225.9 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ADV21452.1 - 6.6e-32 110.3 0.0 9.8e-32 109.8 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 ADV21452.1 - 2.2e-06 28.0 0.0 4.2e-06 27.1 0.0 1.5 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 ADV21452.1 - 0.00058 19.6 0.0 0.0011 18.6 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.6 ADV21452.1 - 0.023 13.9 0.0 0.038 13.2 0.0 1.3 1 0 0 1 1 1 0 Tubulin like Methyltransf_2 PF00891.18 ADV21452.1 - 0.14 11.4 0.1 0.4 9.9 0.0 1.7 2 0 0 2 2 2 0 O-methyltransferase domain PRA1 PF03208.19 ADV21453.1 - 2.6e-36 124.4 0.7 3e-36 124.2 0.7 1.0 1 0 0 1 1 1 1 PRA1 family protein PDR_assoc PF08370.11 ADV21453.1 - 1.1 9.0 4.6 2.4 7.9 2.6 2.4 3 0 0 3 3 3 0 Plant PDR ABC transporter associated DUF1270 PF06900.11 ADV21453.1 - 4.1 7.9 8.4 0.13 12.7 1.5 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1270) Arf PF00025.21 ADV21454.1 - 4.5e-75 250.9 0.0 5.1e-75 250.7 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 ADV21454.1 - 3.9e-14 52.9 0.0 5.2e-14 52.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 ADV21454.1 - 1.7e-12 47.2 0.0 1.9e-12 47.1 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 ADV21454.1 - 6.1e-11 42.1 1.0 2e-06 27.2 0.1 2.4 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 ADV21454.1 - 3.2e-10 39.7 0.0 4.1e-10 39.4 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 ADV21454.1 - 6.5e-09 35.5 0.0 8.3e-09 35.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ADV21454.1 - 0.00039 20.5 0.0 0.00067 19.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 ADV21454.1 - 0.0035 16.7 0.1 0.0051 16.2 0.1 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase SUR7 PF06687.12 ADV21455.1 - 3.7e-16 59.4 16.8 5.4e-16 58.9 16.8 1.2 1 0 0 1 1 1 1 SUR7/PalI family LptF_LptG PF03739.14 ADV21455.1 - 1.6 7.5 9.9 3.1 6.6 9.9 1.4 1 0 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG ApoLp-III PF07464.11 ADV21456.1 - 0.0014 18.7 6.2 2.4 8.3 0.0 3.8 2 1 0 3 3 3 2 Apolipophorin-III precursor (apoLp-III) RHD3 PF05879.12 ADV21456.1 - 0.018 13.2 0.5 0.028 12.6 0.5 1.3 1 0 0 1 1 1 0 Root hair defective 3 GTP-binding protein (RHD3) DUF842 PF05811.13 ADV21456.1 - 0.053 13.2 1.2 0.13 11.9 0.1 2.2 2 1 1 3 3 3 0 Eukaryotic protein of unknown function (DUF842) DUF2884 PF11101.8 ADV21456.1 - 0.1 12.1 1.5 0.63 9.5 0.1 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF2884) NPV_P10 PF05531.12 ADV21456.1 - 2 8.9 10.7 0.24 11.9 2.3 3.4 2 2 1 3 3 3 0 Nucleopolyhedrovirus P10 protein SNARE PF05739.19 ADV21457.1 - 4.1e-10 39.5 0.1 7.8e-10 38.6 0.1 1.5 1 0 0 1 1 1 1 SNARE domain Syntaxin PF00804.25 ADV21457.1 - 5.4e-06 26.2 11.5 1e-05 25.3 11.5 1.5 1 1 0 1 1 1 1 Syntaxin LEF-9 PF05094.12 ADV21457.1 - 0.16 10.4 0.2 0.22 10.0 0.2 1.1 1 0 0 1 1 1 0 Late expression factor 9 (LEF-9) Tup_N PF08581.10 ADV21457.1 - 0.52 10.7 7.1 0.088 13.1 2.3 2.1 2 0 0 2 2 2 0 Tup N-terminal MCPsignal PF00015.21 ADV21457.1 - 1.2 8.9 9.4 0.25 11.2 4.5 2.0 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain TMPIT PF07851.13 ADV21457.1 - 2.5 7.3 5.3 2.2 7.4 0.8 2.1 2 0 0 2 2 2 0 TMPIT-like protein RRM_1 PF00076.22 ADV21458.1 - 1.8e-12 46.9 0.0 2.6e-07 30.3 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) OMPdecase PF00215.24 ADV21459.1 - 1.8e-71 240.3 0.1 2.2e-71 240.0 0.1 1.1 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family SurE PF01975.17 ADV21460.1 - 4.3e-46 157.1 0.0 5.4e-46 156.8 0.0 1.1 1 0 0 1 1 1 1 Survival protein SurE Glyco_hydro_cc PF11790.8 ADV21461.1 - 5.1e-55 186.6 0.8 7.8e-55 186.0 0.8 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core NAM-associated PF14303.6 ADV21461.1 - 2.9 8.6 12.9 2.2 9.0 0.4 2.3 2 0 0 2 2 2 0 No apical meristem-associated C-terminal domain SPX PF03105.19 ADV21461.1 - 9.3 6.0 9.2 12 5.7 9.2 1.1 1 0 0 1 1 1 0 SPX domain DUF4218 PF13960.6 ADV21463.1 - 0.066 12.8 0.0 0.2 11.3 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4218) Aminotran_4 PF01063.19 ADV21463.1 - 0.15 11.9 0.0 0.25 11.2 0.0 1.3 1 0 0 1 1 1 0 Amino-transferase class IV Eaf7 PF07904.13 ADV21464.1 - 5.9e-07 29.8 4.9 8.7e-07 29.3 1.7 2.8 2 1 0 2 2 2 1 Chromatin modification-related protein EAF7 Cse1 PF08506.10 ADV21465.1 - 0.0017 17.2 0.1 0.0053 15.6 0.0 1.7 2 0 0 2 2 2 1 Cse1 Xpo1 PF08389.12 ADV21465.1 - 0.0053 16.8 4.0 0.11 12.5 0.0 4.6 3 2 0 4 4 4 1 Exportin 1-like protein HEAT_EZ PF13513.6 ADV21465.1 - 0.1 13.2 5.9 9 6.9 0.1 4.4 3 1 1 4 4 4 0 HEAT-like repeat RhoGAP PF00620.27 ADV21465.1 - 0.17 11.7 0.1 2.8 7.8 0.0 2.7 2 0 0 2 2 2 0 RhoGAP domain RRM_1 PF00076.22 ADV21466.1 - 1.2e-20 73.1 0.1 1.6e-20 72.7 0.1 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ADV21466.1 - 9.3e-05 22.0 0.0 0.00011 21.8 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 ADV21466.1 - 0.024 14.6 0.0 0.038 14.0 0.0 1.3 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 ADV21466.1 - 0.071 13.2 0.0 0.14 12.3 0.0 1.4 1 1 0 1 1 1 0 RNA binding motif PhyH PF05721.13 ADV21467.1 - 2.7e-06 27.8 0.0 3.9e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Catalase PF00199.19 ADV21468.1 - 3.8e-168 559.5 0.1 4.8e-168 559.2 0.1 1.1 1 0 0 1 1 1 1 Catalase Catalase_C PF18011.1 ADV21468.1 - 4.9e-16 58.7 0.0 8.2e-16 58.0 0.0 1.4 1 0 0 1 1 1 1 C-terminal domain found in long catalases Catalase-rel PF06628.12 ADV21468.1 - 8.6e-16 57.9 0.2 2.4e-15 56.5 0.1 1.9 2 0 0 2 2 2 1 Catalase-related immune-responsive DJ-1_PfpI PF01965.24 ADV21468.1 - 5.2e-09 36.1 0.0 9.4e-09 35.3 0.0 1.4 1 0 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.5 ADV21468.1 - 0.14 11.8 0.1 3.2 7.4 0.0 2.4 1 1 1 2 2 2 0 ThiJ/PfpI family-like aGPT-Pplase3 PF18746.1 ADV21468.1 - 0.24 10.7 1.5 0.43 9.9 1.5 1.3 1 0 0 1 1 1 0 Alpha-glutamyl/putrescinyl thymine pyrophosphorylase clade 3 dCMP_cyt_deam_1 PF00383.23 ADV21469.1 - 8.3e-16 57.7 0.0 1.4e-15 57.0 0.0 1.4 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 ADV21469.1 - 4.3e-12 46.0 0.0 8.4e-12 45.0 0.0 1.4 1 1 0 1 1 1 1 MafB19-like deaminase Inv-AAD PF18785.1 ADV21469.1 - 2.5e-06 27.4 0.0 3.3e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 Invertebrate-AID/APOBEC-deaminase NAC PF01849.18 ADV21470.1 - 4.6e-21 74.5 0.0 8.2e-21 73.7 0.0 1.4 1 0 0 1 1 1 1 NAC domain FRG1 PF06229.12 ADV21471.1 - 8.4e-16 58.2 0.0 1.4e-15 57.5 0.0 1.3 1 0 0 1 1 1 1 FRG1-like domain DUF569 PF04601.13 ADV21471.1 - 0.039 13.6 0.0 0.072 12.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF569) Fascin PF06268.13 ADV21471.1 - 0.041 14.1 0.0 0.11 12.7 0.0 1.8 1 1 0 1 1 1 0 Fascin domain zf-MYND PF01753.18 ADV21472.1 - 0.19 11.8 0.1 0.54 10.4 0.1 1.7 1 0 0 1 1 1 0 MYND finger Tcp10_C PF07202.13 ADV21472.1 - 0.24 11.3 3.4 0.21 11.6 1.1 1.9 2 0 0 2 2 2 0 T-complex protein 10 C-terminus SNARE_assoc PF09335.11 ADV21473.1 - 1.5e-11 44.8 2.6 1.5e-11 44.8 2.6 2.2 2 1 0 2 2 2 1 SNARE associated Golgi protein Glyco_hydro_115 PF15979.5 ADV21474.1 - 1.8e-98 330.1 4.2 1.7e-96 323.6 4.2 2.2 1 1 0 1 1 1 1 Glycosyl hydrolase family 115 GH115_C PF17829.1 ADV21474.1 - 6.8e-51 172.5 0.0 1.3e-50 171.6 0.0 1.4 1 0 0 1 1 1 1 Gylcosyl hydrolase family 115 C-terminal domain Aldo_ket_red PF00248.21 ADV21475.1 - 1.2e-39 136.3 0.0 2.8e-37 128.5 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family MetRS-N PF09635.10 ADV21475.1 - 0.093 13.3 0.0 0.18 12.4 0.0 1.4 1 0 0 1 1 1 0 MetRS-N binding domain Thiolase_N PF00108.23 ADV21476.1 - 4.2e-44 150.8 1.6 2.2e-43 148.5 0.3 2.2 3 0 0 3 3 3 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 ADV21476.1 - 3.4e-35 120.4 0.4 7.7e-35 119.2 0.1 1.6 2 0 0 2 2 2 1 Thiolase, C-terminal domain SelA PF03841.13 ADV21476.1 - 0.029 13.4 0.1 0.039 12.9 0.1 1.2 1 0 0 1 1 1 0 L-seryl-tRNA selenium transferase DUF953 PF06110.11 ADV21477.1 - 3.6e-16 58.9 0.1 4.1e-16 58.7 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF953) Thioredoxin PF00085.20 ADV21477.1 - 0.00013 21.9 0.0 0.00019 21.4 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 ADV21477.1 - 0.02 15.3 0.1 0.044 14.2 0.1 1.6 1 1 0 1 1 1 0 Thioredoxin-like domain GTP_EFTU PF00009.27 ADV21478.1 - 8.1e-51 172.3 0.0 1.2e-50 171.7 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain LepA_C PF06421.12 ADV21478.1 - 2.3e-44 149.9 1.2 4.2e-44 149.1 1.2 1.5 1 0 0 1 1 1 1 GTP-binding protein LepA C-terminus EFG_C PF00679.24 ADV21478.1 - 7.7e-21 73.9 0.0 2.4e-20 72.4 0.0 1.9 2 0 0 2 2 2 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 ADV21478.1 - 8.8e-13 48.5 0.1 1.7e-12 47.5 0.1 1.5 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 ADV21478.1 - 1.8e-05 24.8 0.0 3.5e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase EFG_II PF14492.6 ADV21478.1 - 6.7e-05 22.9 0.0 0.00014 21.9 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II RF3_C PF16658.5 ADV21478.1 - 0.00011 22.1 0.0 0.00022 21.1 0.0 1.4 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain Ras PF00071.22 ADV21478.1 - 0.00066 19.3 0.0 0.0014 18.3 0.0 1.5 1 0 0 1 1 1 1 Ras family MMR_HSR1_Xtn PF16897.5 ADV21478.1 - 0.012 15.7 0.0 0.045 13.8 0.0 2.0 2 0 0 2 2 2 0 C-terminal region of MMR_HSR1 domain SRPRB PF09439.10 ADV21478.1 - 0.14 11.6 0.1 0.66 9.4 0.0 2.2 1 1 1 2 2 2 0 Signal recognition particle receptor beta subunit PPR_3 PF13812.6 ADV21479.1 - 0.0036 17.3 0.0 0.083 13.0 0.0 3.0 3 0 0 3 3 3 1 Pentatricopeptide repeat domain PPR PF01535.20 ADV21479.1 - 0.0094 16.1 0.0 2.3e+02 2.4 0.0 5.3 6 0 0 6 6 6 0 PPR repeat PPR_long PF17177.4 ADV21479.1 - 0.14 11.5 0.2 0.53 9.6 0.0 2.0 3 0 0 3 3 3 0 Pentacotripeptide-repeat region of PRORP PAP2_3 PF14378.6 ADV21480.1 - 3.4e-46 157.3 10.0 6.7e-46 156.4 10.0 1.5 1 0 0 1 1 1 1 PAP2 superfamily PAP2_C PF14360.6 ADV21480.1 - 4.6e-05 23.9 0.9 4.6e-05 23.9 0.9 2.5 3 0 0 3 3 3 1 PAP2 superfamily C-terminal PAP2 PF01569.21 ADV21480.1 - 5.5e-05 23.0 0.5 5.5e-05 23.0 0.5 2.6 2 1 0 2 2 2 1 PAP2 superfamily zf-C2H2 PF00096.26 ADV21481.1 - 3.8e-07 30.2 5.3 0.024 15.1 0.1 3.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ADV21481.1 - 9e-07 29.0 5.8 2.6e-05 24.5 0.6 2.8 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 ADV21481.1 - 4.1e-06 27.2 4.6 0.056 14.3 1.6 3.2 2 0 0 2 2 2 2 C2H2-type zinc finger zf-Di19 PF05605.12 ADV21481.1 - 0.00035 20.8 1.7 0.00083 19.6 1.7 1.6 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.8 ADV21481.1 - 0.0027 17.9 0.1 4.9 7.5 0.0 2.8 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 ADV21481.1 - 0.016 15.2 6.4 1.5 8.9 1.7 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 ADV21481.1 - 0.019 15.7 2.0 0.23 12.1 0.4 2.4 2 0 0 2 2 2 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_2 PF12756.7 ADV21481.1 - 0.35 11.2 5.1 13 6.2 0.2 2.5 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-AN1 PF01428.16 ADV21481.1 - 0.44 10.8 4.3 2.7 8.2 0.7 2.6 2 0 0 2 2 2 0 AN1-like Zinc finger Zn-ribbon_8 PF09723.10 ADV21481.1 - 0.53 10.4 3.7 1.8 8.7 3.7 1.9 1 0 0 1 1 1 0 Zinc ribbon domain LIM PF00412.22 ADV21481.1 - 1 9.7 6.1 1.7 8.9 1.6 2.6 1 1 1 2 2 2 0 LIM domain zf-LYAR PF08790.11 ADV21481.1 - 1.2 9.2 5.0 0.79 9.7 1.6 2.3 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger zf-met PF12874.7 ADV21481.1 - 1.9 9.0 4.0 6.4 7.3 0.0 3.2 3 0 0 3 3 2 0 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.6 ADV21481.1 - 2.5 7.9 5.7 0.39 10.5 0.2 2.5 3 0 0 3 3 3 0 C2H2-type zinc-finger domain ATP-synt_C PF00137.21 ADV21482.1 - 0.031 14.6 1.0 0.087 13.2 1.0 1.8 1 0 0 1 1 1 0 ATP synthase subunit C RRM_1 PF00076.22 ADV21483.1 - 3.8e-43 145.2 0.0 4.6e-13 48.8 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 ADV21483.1 - 3.2e-06 27.1 0.1 0.028 14.5 0.0 3.4 3 2 0 3 3 3 2 Limkain b1 RRM_Rrp7 PF17799.1 ADV21483.1 - 0.1 12.4 0.0 2.4 7.9 0.0 2.6 3 0 0 3 3 3 0 Rrp7 RRM-like N-terminal domain RRM_5 PF13893.6 ADV21483.1 - 0.16 11.5 0.0 15 5.2 0.0 2.9 3 0 0 3 3 3 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Catalase PF00199.19 ADV21484.1 - 1.4e-174 580.7 0.0 1.8e-174 580.3 0.0 1.1 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 ADV21484.1 - 1.2e-16 60.7 0.0 2.4e-16 59.7 0.0 1.6 1 0 0 1 1 1 1 Catalase-related immune-responsive Peptidase_M24 PF00557.24 ADV21485.1 - 1.7e-13 50.8 0.0 2.1e-13 50.4 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Frataxin_Cyay PF01491.16 ADV21486.1 - 6.8e-32 109.8 0.0 9.1e-32 109.4 0.0 1.2 1 0 0 1 1 1 1 Frataxin-like domain IF-2B PF01008.17 ADV21487.1 - 4.6e-53 180.3 0.0 7.2e-53 179.6 0.0 1.3 1 1 0 1 1 1 1 Initiation factor 2 subunit family Pkinase PF00069.25 ADV21488.1 - 5.5e-60 203.0 0.0 1.4e-58 198.4 0.0 2.4 2 1 0 2 2 2 1 Protein kinase domain DUF3543 PF12063.8 ADV21488.1 - 5.6e-52 176.6 0.4 7.4e-51 172.9 0.4 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF3543) Pkinase_Tyr PF07714.17 ADV21488.1 - 8.4e-38 130.1 0.0 1.3e-37 129.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ADV21488.1 - 9e-05 22.5 0.5 0.0058 16.6 0.0 3.3 3 2 0 3 3 3 1 Phosphotransferase enzyme family Kdo PF06293.14 ADV21488.1 - 0.02 14.2 0.0 0.039 13.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family MIT PF04212.18 ADV21488.1 - 0.38 10.9 1.7 2.2 8.4 0.2 2.5 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain PEHE PF15275.6 ADV21491.1 - 2.1e-05 25.2 0.8 2.1e-05 25.2 0.8 3.1 2 1 0 2 2 2 1 PEHE domain SAS4 PF15460.6 ADV21491.1 - 0.0024 17.9 2.9 0.0075 16.3 2.9 1.9 1 1 0 1 1 1 1 Something about silencing, SAS, complex subunit 4 TTL PF03133.15 ADV21492.1 - 5.7e-32 111.0 0.0 1.6e-30 106.2 0.0 2.5 1 1 0 1 1 1 1 Tubulin-tyrosine ligase family RRM_1 PF00076.22 ADV21492.1 - 0.078 12.8 0.0 19 5.2 0.0 3.0 3 0 0 3 3 3 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FRQ PF09421.10 ADV21492.1 - 2.3 6.1 5.0 3.3 5.6 5.0 1.1 1 0 0 1 1 1 0 Frequency clock protein CDC45 PF02724.14 ADV21492.1 - 5.1 5.3 5.4 7.3 4.8 5.4 1.1 1 0 0 1 1 1 0 CDC45-like protein SRP14 PF02290.15 ADV21493.1 - 1e-18 67.4 0.0 5.6e-18 65.1 0.0 2.0 1 1 1 2 2 2 1 Signal recognition particle 14kD protein DUF4407 PF14362.6 ADV21493.1 - 0.19 11.0 2.4 0.21 10.9 2.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Jak1_Phl PF17887.1 ADV21493.1 - 7.6 6.5 7.9 1.6 8.7 0.2 2.1 1 1 1 2 2 2 0 Jak1 pleckstrin homology-like domain Aldedh PF00171.22 ADV21494.1 - 8.1e-18 64.2 11.9 1.9e-09 36.5 10.2 2.6 2 1 0 2 2 2 2 Aldehyde dehydrogenase family Osmo_MPGsynth PF09488.10 ADV21494.1 - 0.034 12.9 0.0 0.052 12.2 0.0 1.2 1 0 0 1 1 1 0 Mannosyl-3-phosphoglycerate synthase (osmo_MPGsynth) zf-RING_2 PF13639.6 ADV21495.1 - 3.3e-12 46.5 5.4 5.1e-12 45.9 5.4 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 ADV21495.1 - 5.4e-10 38.8 3.4 9.4e-10 38.1 3.4 1.4 1 0 0 1 1 1 1 RING-like zinc finger PA PF02225.22 ADV21495.1 - 1.9e-08 34.2 0.0 4.6e-08 33.0 0.0 1.7 1 0 0 1 1 1 1 PA domain zf-C3HC4_3 PF13920.6 ADV21495.1 - 3.5e-08 33.2 2.0 5.3e-08 32.6 2.0 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ADV21495.1 - 1.9e-07 30.8 5.1 3e-07 30.1 5.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ADV21495.1 - 1.6e-05 24.8 2.2 2.4e-05 24.2 2.2 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 ADV21495.1 - 0.00019 21.4 2.8 0.00039 20.4 2.8 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 ADV21495.1 - 0.00046 20.0 3.7 0.00072 19.4 3.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ADV21495.1 - 0.0037 17.5 8.8 0.017 15.4 8.8 1.9 1 1 0 1 1 1 1 RING-H2 zinc finger domain Prok-RING_1 PF14446.6 ADV21495.1 - 0.018 15.0 1.0 0.018 15.0 1.0 1.8 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 Prok-RING_4 PF14447.6 ADV21495.1 - 0.072 13.0 2.9 0.12 12.2 2.9 1.3 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Zn_ribbon_17 PF17120.5 ADV21495.1 - 0.24 11.1 3.6 0.42 10.3 3.6 1.3 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-ANAPC11 PF12861.7 ADV21495.1 - 0.27 11.3 1.5 0.56 10.3 1.5 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger CRAL_TRIO PF00650.20 ADV21496.1 - 3.3e-38 130.9 0.0 4.8e-38 130.4 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 ADV21496.1 - 1.5e-06 28.4 0.0 2.2e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO_N PF03765.15 ADV21496.1 - 0.00077 19.6 0.2 0.0016 18.6 0.2 1.5 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain Transp_cyt_pur PF02133.15 ADV21497.1 - 4e-38 131.3 33.7 5.3e-38 130.9 33.7 1.2 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin LSM PF01423.22 ADV21498.1 - 1.5e-11 43.8 0.4 1.1e-05 25.0 0.1 2.4 2 0 0 2 2 2 2 LSM domain Hfq PF17209.3 ADV21498.1 - 0.023 14.3 0.0 0.047 13.4 0.0 1.4 1 0 0 1 1 1 0 Hfq protein RAC_head PF16717.5 ADV21500.1 - 8e-23 81.3 5.5 8e-23 81.3 5.5 3.0 2 1 0 3 3 3 1 Ribosome-associated complex head domain DnaJ PF00226.31 ADV21500.1 - 8.1e-16 57.9 0.2 3e-15 56.1 0.2 2.1 1 0 0 1 1 1 1 DnaJ domain SpoVR PF04293.13 ADV21500.1 - 0.14 10.8 7.0 0.23 10.1 7.0 1.2 1 0 0 1 1 1 0 SpoVR like protein TrmO_C PF18389.1 ADV21500.1 - 0.16 12.1 0.5 0.63 10.2 0.1 2.3 2 0 0 2 2 2 0 TrmO C-terminal domain DUF5427 PF10310.9 ADV21500.1 - 1.1 8.1 23.4 1.9 7.4 23.4 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5427) UPF0239 PF06783.11 ADV21501.1 - 1.8 8.8 0.0 1.8 8.8 0.0 2.8 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0239) Sec1 PF00995.23 ADV21502.1 - 1.3e-120 404.4 0.0 1.5e-120 404.1 0.0 1.1 1 0 0 1 1 1 1 Sec1 family UDPG_MGDP_dh_N PF03721.14 ADV21503.1 - 4.1e-62 209.1 0.1 8.7e-62 208.0 0.0 1.5 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh_C PF03720.15 ADV21503.1 - 6.9e-36 122.9 0.0 6e-35 119.8 0.0 2.2 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain UDPG_MGDP_dh PF00984.19 ADV21503.1 - 1.5e-30 105.2 0.0 2.8e-30 104.4 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain NAD_binding_2 PF03446.15 ADV21503.1 - 0.001 19.2 0.0 0.37 11.0 0.0 2.5 2 0 0 2 2 2 2 NAD binding domain of 6-phosphogluconate dehydrogenase KH_5 PF13184.6 ADV21503.1 - 0.098 12.8 0.1 12 6.1 0.0 3.4 3 0 0 3 3 3 0 NusA-like KH domain Sacchrp_dh_NADP PF03435.18 ADV21503.1 - 0.13 12.5 0.2 0.44 10.8 0.0 2.0 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain 3HCDH_N PF02737.18 ADV21503.1 - 0.14 12.1 0.0 0.5 10.2 0.0 2.0 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2OG-FeII_Oxy PF03171.20 ADV21504.1 - 6.6e-05 23.3 0.0 0.00011 22.7 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily ABC_tran PF00005.27 ADV21505.1 - 5.6e-07 30.2 0.0 8.7e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 ABC transporter ABC_trans_N PF14510.6 ADV21505.1 - 0.15 12.7 0.0 0.36 11.5 0.0 1.6 1 0 0 1 1 1 0 ABC-transporter N-terminal FMN_bind_2 PF04299.12 ADV21506.1 - 6.2e-57 192.0 0.1 7.3e-57 191.7 0.1 1.1 1 0 0 1 1 1 1 Putative FMN-binding domain Myosin_tail_1 PF01576.19 ADV21507.1 - 7.6e-06 24.1 94.7 0.0024 15.8 27.7 3.1 1 1 1 2 2 2 2 Myosin tail TPR_MLP1_2 PF07926.12 ADV21507.1 - 0.00096 19.2 7.1 0.00096 19.2 7.1 7.7 2 1 4 7 7 7 3 TPR/MLP1/MLP2-like protein Filament PF00038.21 ADV21507.1 - 0.33 10.5 87.5 0.0072 15.9 48.0 4.1 2 2 2 4 4 4 0 Intermediate filament protein GlcNAc-1_reg PF18440.1 ADV21507.1 - 5.4 7.3 6.6 3.5 7.9 0.4 3.6 2 1 1 3 3 3 0 Putative GlcNAc-1 phosphotransferase regulatory domain Baculo_PEP_C PF04513.12 ADV21507.1 - 6.1 6.9 42.2 3.6 7.6 0.1 6.5 2 2 4 7 7 7 0 Baculovirus polyhedron envelope protein, PEP, C terminus UFD1 PF03152.14 ADV21508.1 - 2.3e-64 216.0 0.0 3.3e-64 215.5 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 Nup35_RRM PF05172.13 ADV21509.1 - 4.5e-05 23.3 0.0 8.6e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif 2-Hacid_dh_C PF02826.19 ADV21510.1 - 8.9e-43 145.7 0.0 4e-41 140.3 0.0 3.0 3 1 0 3 3 3 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 ADV21510.1 - 0.0013 19.0 0.0 0.0031 17.7 0.0 1.6 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.12 ADV21510.1 - 0.011 15.3 0.0 0.069 12.7 0.0 2.1 2 1 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain DAHP_synth_1 PF00793.20 ADV21511.1 - 7.6e-99 330.0 0.0 9.6e-99 329.7 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family Glyco_transf_18 PF15024.6 ADV21512.1 - 8.1e-08 31.3 0.0 1.1e-07 30.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 18 DAO PF01266.24 ADV21513.1 - 1.5e-32 113.6 0.0 1.9e-32 113.2 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ADV21513.1 - 0.00028 20.2 0.0 0.069 12.4 0.0 2.7 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ADV21513.1 - 0.00057 20.1 0.0 0.0021 18.3 0.0 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_Gly3P_dh_N PF01210.23 ADV21513.1 - 0.05 13.6 0.0 0.084 12.8 0.0 1.3 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Shikimate_DH PF01488.20 ADV21513.1 - 0.068 13.2 0.0 0.64 10.1 0.0 2.1 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Pyr_redox_3 PF13738.6 ADV21513.1 - 0.15 11.3 0.0 0.31 10.2 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Glyco_hydro_88 PF07470.13 ADV21514.1 - 4.4e-16 58.9 0.3 7.3e-16 58.2 0.3 1.4 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 LdpA_C PF12617.8 ADV21514.1 - 0.062 12.9 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 Iron-Sulfur binding protein C terminal DUF21 PF01595.20 ADV21515.1 - 1.7e-40 138.6 0.1 3.1e-40 137.7 0.1 1.3 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain Topoisom_bac PF01131.20 ADV21515.1 - 0.077 12.0 0.2 0.14 11.2 0.2 1.3 1 0 0 1 1 1 0 DNA topoisomerase SR-25 PF10500.9 ADV21515.1 - 0.16 11.6 13.2 0.32 10.6 13.2 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein NmrA PF05368.13 ADV21516.1 - 5.3e-17 62.1 0.0 1.4e-12 47.7 0.0 2.1 2 0 0 2 2 2 2 NmrA-like family NAD_binding_10 PF13460.6 ADV21516.1 - 2.6e-08 34.0 0.0 4.2e-08 33.3 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Cnd2 PF05786.14 ADV21517.1 - 5.7e-166 554.4 0.0 3.7e-165 551.7 0.0 1.8 1 1 0 1 1 1 1 Condensin complex subunit 2 Ribonuc_L-PSP PF01042.21 ADV21518.1 - 0.0002 21.3 0.0 0.0003 20.8 0.0 1.3 1 0 0 1 1 1 1 Endoribonuclease L-PSP adh_short_C2 PF13561.6 ADV21519.1 - 5.1e-55 186.6 4.0 5.9e-55 186.4 4.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ADV21519.1 - 4.1e-44 150.4 3.0 5.1e-44 150.1 3.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ADV21519.1 - 9.4e-16 58.2 1.9 1.3e-15 57.8 1.9 1.1 1 0 0 1 1 1 1 KR domain YAcAr PF10686.9 ADV21519.1 - 0.0041 17.1 0.2 0.02 14.8 0.0 2.2 2 1 0 2 2 2 1 YspA, cpYpsA-related SLOG family Pyr_redox_2 PF07992.14 ADV21519.1 - 0.0068 15.7 0.1 0.0098 15.2 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Epimerase PF01370.21 ADV21519.1 - 0.018 14.5 1.1 0.093 12.2 1.1 2.0 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family DFP PF04127.15 ADV21519.1 - 0.055 13.3 1.1 0.12 12.2 0.6 1.7 1 1 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein Eno-Rase_NADH_b PF12242.8 ADV21519.1 - 0.07 12.9 0.6 0.14 11.9 0.1 1.7 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase 3HCDH_N PF02737.18 ADV21519.1 - 0.09 12.7 0.3 0.15 12.0 0.3 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Amino_oxidase PF01593.24 ADV21520.1 - 1.3e-52 179.6 0.3 1.5e-52 179.4 0.3 1.0 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 ADV21520.1 - 8.3e-13 48.4 0.3 2.2e-12 47.0 0.3 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 ADV21520.1 - 2.5e-12 47.1 3.5 1e-11 45.1 3.2 2.1 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 ADV21520.1 - 2.5e-08 33.4 0.0 8.4e-08 31.7 0.0 1.8 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.14 ADV21520.1 - 1.3e-07 30.7 0.0 3.1e-07 29.5 0.1 1.6 2 0 0 2 2 2 1 HI0933-like protein FAD_oxidored PF12831.7 ADV21520.1 - 2.9e-07 30.2 1.5 4.5e-07 29.6 0.4 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 ADV21520.1 - 5.8e-07 29.0 0.0 1.1e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.14 ADV21520.1 - 2.5e-06 26.9 0.1 4.3e-06 26.2 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 ADV21520.1 - 7.9e-06 25.4 0.8 2.7e-05 23.6 0.3 1.9 2 0 0 2 2 2 1 FAD binding domain Pyr_redox PF00070.27 ADV21520.1 - 8.3e-06 26.3 0.3 1.9e-05 25.1 0.3 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 ADV21520.1 - 0.00011 21.5 0.1 0.00016 20.9 0.1 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A Lycopene_cycl PF05834.12 ADV21520.1 - 0.00016 20.8 0.2 0.00024 20.3 0.2 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_9 PF13454.6 ADV21520.1 - 0.01 15.8 0.4 0.037 14.0 0.2 2.0 2 0 0 2 2 2 0 FAD-NAD(P)-binding AlaDh_PNT_C PF01262.21 ADV21520.1 - 0.014 14.7 0.0 0.023 14.0 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_3 PF13738.6 ADV21520.1 - 0.031 13.5 0.0 0.26 10.5 0.0 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase UDPG_MGDP_dh_N PF03721.14 ADV21520.1 - 0.14 11.7 0.1 0.23 11.0 0.1 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain DUF1638 PF07796.11 ADV21520.1 - 0.19 11.8 0.0 0.42 10.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1638) Amino_oxidase PF01593.24 ADV21521.1 - 1e-51 176.7 0.1 1.2e-51 176.5 0.1 1.0 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 ADV21521.1 - 1.9e-13 50.4 1.2 4.5e-13 49.2 0.4 2.1 3 0 0 3 3 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 ADV21521.1 - 1.5e-09 37.4 4.1 3.7e-09 36.2 2.3 2.1 2 0 0 2 2 2 1 FAD binding domain DAO PF01266.24 ADV21521.1 - 1.3e-08 34.8 0.1 2.2e-08 34.1 0.1 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 ADV21521.1 - 6.5e-07 28.4 0.8 1.2e-06 27.5 0.8 1.4 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_3 PF01494.19 ADV21521.1 - 9.7e-07 28.3 0.9 1.9e-06 27.4 0.9 1.4 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 ADV21521.1 - 1e-06 28.2 0.0 5.6e-05 22.5 0.1 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 ADV21521.1 - 1.3e-06 28.0 5.2 2.2e-06 27.3 4.7 1.6 1 1 1 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 ADV21521.1 - 2.4e-06 27.0 0.2 4e-06 26.2 0.2 1.2 1 0 0 1 1 1 1 Thi4 family Lycopene_cycl PF05834.12 ADV21521.1 - 5.6e-06 25.6 0.5 0.0063 15.6 0.7 2.1 2 0 0 2 2 2 2 Lycopene cyclase protein AlaDh_PNT_C PF01262.21 ADV21521.1 - 0.00022 20.6 1.2 0.00034 20.0 0.7 1.5 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.27 ADV21521.1 - 0.00061 20.3 1.1 0.0027 18.2 1.2 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 ADV21521.1 - 0.0021 17.2 0.5 0.0094 15.1 0.8 1.8 2 0 0 2 2 2 1 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 ADV21521.1 - 0.04 13.2 1.2 0.073 12.3 0.9 1.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 ADV21521.1 - 0.066 13.2 1.4 8.3 6.4 0.6 2.9 4 0 0 4 4 4 0 FAD-NAD(P)-binding Med12-PQL PF12144.8 ADV21521.1 - 0.13 12.1 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 Eukaryotic Mediator 12 catenin-binding domain MtrD PF04207.12 ADV21521.1 - 0.26 11.0 0.8 0.42 10.3 0.8 1.2 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit D PALP PF00291.25 ADV21522.1 - 4.1e-66 223.4 0.2 5e-66 223.1 0.2 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme OrsD PF12013.8 ADV21523.1 - 0.047 14.1 0.2 0.047 14.1 0.2 1.8 2 0 0 2 2 2 0 Orsellinic acid/F9775 biosynthesis cluster protein D AIF_C PF14721.6 ADV21523.1 - 0.31 11.4 5.4 0.8 10.1 0.1 2.4 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term CTU2 PF10288.9 ADV21523.1 - 5.7 7.2 13.2 0.17 12.2 0.7 2.6 2 1 0 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 Plasmodium_Vir PF05795.11 ADV21523.1 - 7.7 5.8 10.3 0.51 9.7 0.4 2.1 2 0 0 2 2 2 0 Plasmodium vivax Vir protein NAD_binding_9 PF13454.6 ADV21525.1 - 0.00059 19.9 0.0 0.0016 18.4 0.0 1.7 1 0 0 1 1 1 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 ADV21525.1 - 0.00099 18.4 0.0 9 5.4 0.0 3.2 3 0 0 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase tRNA-synt_His PF13393.6 ADV21525.1 - 0.18 11.0 0.0 0.48 9.6 0.0 1.7 1 1 1 2 2 2 0 Histidyl-tRNA synthetase RabGAP-TBC PF00566.18 ADV21526.1 - 1.4e-20 73.9 0.0 1.8e-20 73.5 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain SBE2 PF17076.5 ADV21526.1 - 3.7e-05 22.2 0.7 6.4e-05 21.4 0.7 1.3 1 0 0 1 1 1 1 SBE2, cell-wall formation Adaptin_binding PF10199.9 ADV21526.1 - 0.00062 20.4 0.4 0.0013 19.3 0.4 1.5 1 0 0 1 1 1 1 Alpha and gamma adaptin binding protein p34 UBN_AB PF14075.6 ADV21527.1 - 2.9e-21 76.2 0.4 2.9e-21 76.2 0.4 3.2 4 1 0 4 4 4 1 Ubinuclein conserved middle domain HUN PF08729.10 ADV21527.1 - 9.1e-14 51.2 0.0 2.8e-13 49.6 0.0 1.9 1 0 0 1 1 1 1 HPC2 and ubinuclein domain Mpv17_PMP22 PF04117.12 ADV21528.1 - 3.8e-18 65.5 0.5 3.8e-18 65.5 0.5 2.1 2 0 0 2 2 2 1 Mpv17 / PMP22 family DUF4140 PF13600.6 ADV21528.1 - 0.14 12.6 1.7 0.23 11.9 1.7 1.4 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) SNARE PF05739.19 ADV21528.1 - 0.74 9.9 2.1 1.6 8.8 2.1 1.6 1 0 0 1 1 1 0 SNARE domain Romo1 PF10247.9 ADV21529.1 - 6.2e-29 100.2 9.8 7.6e-29 99.9 9.8 1.1 1 0 0 1 1 1 1 Reactive mitochondrial oxygen species modulator 1 Tim17 PF02466.19 ADV21529.1 - 0.031 14.7 0.7 0.037 14.4 0.7 1.2 1 0 0 1 1 1 0 Tim17/Tim22/Tim23/Pmp24 family DUF3021 PF11457.8 ADV21529.1 - 0.037 14.3 1.3 0.045 14.1 1.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3021) ArfGap PF01412.18 ADV21530.1 - 2.2e-38 130.9 0.1 4.8e-38 129.8 0.1 1.6 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf CENP-T_C PF15511.6 ADV21531.1 - 4.7e-08 33.1 0.0 5.8e-08 32.8 0.0 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAF PF02969.17 ADV21531.1 - 8.4e-05 22.7 0.1 0.00012 22.2 0.1 1.3 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-S PF15630.6 ADV21531.1 - 0.00017 21.9 0.0 0.00022 21.5 0.0 1.3 1 1 0 1 1 1 1 CENP-S protein Histone PF00125.24 ADV21531.1 - 0.0011 19.4 0.1 0.0012 19.2 0.1 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 ADV21531.1 - 0.0018 18.5 0.0 0.0029 17.9 0.0 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 ADV21531.1 - 0.071 13.2 0.0 0.08 13.0 0.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Tmemb_cc2 PF10267.9 ADV21532.1 - 0.13 11.4 1.7 0.17 11.0 1.7 1.2 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein TMF_DNA_bd PF12329.8 ADV21532.1 - 0.53 10.3 2.8 1 9.4 2.8 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding Kin17_mid PF10357.9 ADV21533.1 - 5.1e-46 155.7 0.5 7.3e-46 155.2 0.5 1.2 1 0 0 1 1 1 1 Domain of Kin17 curved DNA-binding protein zf-C2H2_jaz PF12171.8 ADV21533.1 - 8e-07 29.2 2.4 2.2e-06 27.8 2.4 1.8 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 ADV21533.1 - 3.4e-05 24.1 2.8 7.6e-05 23.0 2.8 1.6 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 ADV21533.1 - 0.018 15.4 0.9 0.051 13.9 0.1 1.9 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) Mg_trans_NIPA PF05653.14 ADV21534.1 - 1.7e-47 161.9 0.9 2.4e-47 161.5 0.9 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 ADV21534.1 - 6.7e-05 23.1 2.5 6.7e-05 23.1 2.5 3.1 2 1 1 3 3 3 1 EamA-like transporter family PBP1_TM PF14812.6 ADV21534.1 - 0.1 13.0 0.1 0.23 11.8 0.1 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Transketolase_C PF02780.20 ADV21535.1 - 2e-39 134.3 0.1 4.8e-39 133.1 0.1 1.7 1 0 0 1 1 1 1 Transketolase, C-terminal domain Transket_pyr PF02779.24 ADV21535.1 - 4.9e-37 127.3 0.2 5.5e-35 120.6 0.2 2.3 1 1 0 1 1 1 1 Transketolase, pyrimidine binding domain PFOR_II PF17147.4 ADV21535.1 - 0.0043 17.3 0.1 0.016 15.5 0.0 1.9 2 0 0 2 2 2 1 Pyruvate:ferredoxin oxidoreductase core domain II COG2 PF06148.11 ADV21537.1 - 1.7e-33 115.6 0.7 9.1e-33 113.2 0.6 2.2 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 DUF3510 PF12022.8 ADV21537.1 - 5.1e-23 81.8 0.7 3.3e-22 79.2 0.0 2.7 4 0 0 4 4 4 1 Domain of unknown function (DUF3510) Vps51 PF08700.11 ADV21537.1 - 0.052 13.6 0.1 1.4 9.0 0.0 3.3 4 0 0 4 4 4 0 Vps51/Vps67 Spc7 PF08317.11 ADV21537.1 - 0.16 10.8 4.5 0.094 11.6 2.0 1.7 1 1 1 2 2 2 0 Spc7 kinetochore protein Occludin_ELL PF07303.13 ADV21537.1 - 0.47 11.2 2.8 1.6 9.5 0.1 3.1 2 1 1 3 3 3 0 Occludin homology domain MnmE_helical PF12631.7 ADV21537.1 - 0.56 10.3 3.8 4.7 7.3 3.8 2.7 1 1 0 1 1 1 0 MnmE helical domain Vir_act_alpha_C PF10400.9 ADV21537.1 - 4 8.2 6.9 8.1 7.2 0.7 2.9 2 0 0 2 2 2 0 Virulence activator alpha C-term TB2_DP1_HVA22 PF03134.19 ADV21538.1 - 6.6e-14 51.6 0.1 1.1e-13 50.8 0.1 1.3 1 0 0 1 1 1 1 TB2/DP1, HVA22 family Nop14 PF04147.12 ADV21538.1 - 0.99 7.5 7.7 1.6 6.9 7.7 1.3 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 ADV21538.1 - 2.4 6.3 7.0 4 5.6 7.0 1.3 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 ADV21538.1 - 4.1 6.1 4.8 7 5.3 4.8 1.4 1 0 0 1 1 1 0 Presenilin NPR3 PF03666.13 ADV21538.1 - 5 5.8 6.0 7.1 5.3 6.0 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Glyco_hydro_15 PF00723.21 ADV21539.1 - 7.2e-52 176.7 0.0 2.4e-48 165.0 0.0 2.0 1 1 1 2 2 2 2 Glycosyl hydrolases family 15 Rit1_C PF17184.4 ADV21540.1 - 1.2e-82 277.5 0.0 1.6e-82 277.0 0.0 1.1 1 0 0 1 1 1 1 Rit1 N-terminal domain Init_tRNA_PT PF04179.12 ADV21540.1 - 3.5e-18 65.9 0.0 6.3e-18 65.1 0.0 1.4 1 0 0 1 1 1 1 Rit1 DUSP-like domain Frag1 PF10277.9 ADV21541.1 - 1e-07 31.7 4.5 1e-07 31.7 4.5 2.8 3 1 0 3 3 3 1 Frag1/DRAM/Sfk1 family Exo_endo_phos PF03372.23 ADV21541.1 - 0.08 12.5 0.0 0.16 11.4 0.0 1.5 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family SUI1 PF01253.22 ADV21542.1 - 2e-22 79.5 0.0 4.2e-22 78.5 0.0 1.6 1 0 0 1 1 1 1 Translation initiation factor SUI1 Pre-PUA PF17832.1 ADV21542.1 - 8.2e-09 36.0 0.1 6.5e-07 30.0 0.0 2.6 2 0 0 2 2 2 1 Pre-PUA-like domain SWIB PF02201.18 ADV21542.1 - 0.00027 20.8 0.0 0.00073 19.4 0.0 1.8 1 0 0 1 1 1 1 SWIB/MDM2 domain Kin17_mid PF10357.9 ADV21542.1 - 0.013 15.4 0.3 0.022 14.7 0.3 1.3 1 0 0 1 1 1 0 Domain of Kin17 curved DNA-binding protein FAM220 PF15487.6 ADV21542.1 - 0.093 12.3 0.8 0.19 11.3 0.0 1.8 2 0 0 2 2 2 0 FAM220 family PUL PF08324.11 ADV21543.1 - 4.2e-51 173.8 0.2 5.6e-51 173.4 0.2 1.2 1 0 0 1 1 1 1 PUL domain PFU PF09070.11 ADV21543.1 - 2.9e-44 149.9 0.3 6.5e-44 148.8 0.3 1.6 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) WD40 PF00400.32 ADV21543.1 - 6.7e-23 80.6 7.9 7.9e-06 26.5 0.0 6.7 6 0 0 6 6 6 6 WD domain, G-beta repeat Urm1 PF09138.11 ADV21544.1 - 7.1e-35 119.3 0.0 9.9e-35 118.8 0.0 1.2 1 0 0 1 1 1 1 Urm1 (Ubiquitin related modifier) ThiS PF02597.20 ADV21544.1 - 0.0012 19.4 0.0 0.0019 18.8 0.0 1.4 1 0 0 1 1 1 1 ThiS family Mitofilin PF09731.9 ADV21545.1 - 4.7e-164 547.7 21.6 5.5e-164 547.4 21.6 1.0 1 0 0 1 1 1 1 Mitochondrial inner membrane protein PE PF00934.20 ADV21545.1 - 0.038 14.3 0.4 0.2 12.0 0.4 2.3 1 0 0 1 1 1 0 PE family GldM_N PF12081.8 ADV21545.1 - 0.34 11.0 13.1 0.16 12.0 1.1 2.6 2 0 0 2 2 2 0 GldM N-terminal domain NPV_P10 PF05531.12 ADV21545.1 - 0.6 10.6 9.2 1 9.9 1.1 4.3 2 2 2 5 5 5 0 Nucleopolyhedrovirus P10 protein Apolipoprotein PF01442.18 ADV21545.1 - 2.9 7.7 44.4 0.12 12.3 13.0 4.1 2 2 1 3 3 3 0 Apolipoprotein A1/A4/E domain ADH_zinc_N PF00107.26 ADV21546.1 - 2.4e-21 76.1 0.0 3.8e-21 75.4 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ADV21546.1 - 2.9e-16 60.7 0.0 5.3e-16 59.9 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ADV21546.1 - 7.4e-10 38.7 0.0 1.1e-08 34.9 0.0 2.5 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_N_2 PF16884.5 ADV21546.1 - 0.026 14.4 0.0 0.055 13.4 0.0 1.5 1 0 0 1 1 1 0 N-terminal domain of oxidoreductase MRP-L28 PF09812.9 ADV21547.1 - 0.0013 18.9 0.4 0.0013 18.9 0.4 1.7 2 0 0 2 2 2 1 Mitochondrial ribosomal protein L28 Homeodomain PF00046.29 ADV21548.1 - 2.8e-12 46.3 2.1 6.9e-12 45.0 2.1 1.7 1 0 0 1 1 1 1 Homeodomain RBDV_coat PF06593.11 ADV21548.1 - 0.025 14.0 0.0 0.07 12.6 0.0 1.7 2 0 0 2 2 2 0 Raspberry bushy dwarf virus coat protein adh_short PF00106.25 ADV21549.1 - 1.3e-21 76.9 0.0 2.6e-07 30.3 0.0 3.1 2 1 1 3 3 3 3 short chain dehydrogenase adh_short_C2 PF13561.6 ADV21549.1 - 4.4e-15 55.9 0.0 2.6e-07 30.4 0.0 3.1 2 1 1 3 3 3 3 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ADV21549.1 - 1.6e-05 24.9 0.0 2.7e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ADV21549.1 - 0.037 13.5 0.0 0.048 13.1 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Carb_kinase PF01256.17 ADV21550.1 - 2.3e-45 155.0 0.0 6e-45 153.6 0.0 1.6 1 1 0 1 1 1 1 Carbohydrate kinase ENTH PF01417.20 ADV21552.1 - 2.3e-39 134.3 0.0 5.1e-39 133.2 0.0 1.6 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.16 ADV21552.1 - 0.16 10.9 0.1 0.3 10.0 0.0 1.5 2 0 0 2 2 2 0 ANTH domain TFIIF_beta PF02270.15 ADV21553.1 - 2.3e-25 88.5 0.7 4.3e-25 87.6 0.7 1.5 1 0 0 1 1 1 1 TFIIF, beta subunit HTH domain TFIIF_beta_N PF17683.1 ADV21553.1 - 1.1e-19 71.4 0.6 1.8e-19 70.8 0.6 1.3 1 0 0 1 1 1 1 TFIIF, beta subunit N-terminus DXP_redisom_C PF08436.12 ADV21553.1 - 0.057 13.6 0.0 0.17 12.1 0.0 1.7 1 0 0 1 1 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal domain RF-1 PF00472.20 ADV21554.1 - 1.6e-21 76.4 0.1 1.6e-21 76.4 0.1 2.6 2 1 0 2 2 2 1 RF-1 domain CBS PF00571.28 ADV21555.1 - 2.6e-31 107.8 8.7 1.4e-08 35.0 0.0 5.8 5 1 0 5 5 5 4 CBS domain PB1 PF00564.24 ADV21555.1 - 1.1e-08 34.8 0.4 8e-08 32.1 0.1 2.5 2 1 0 2 2 2 1 PB1 domain DUF573 PF04504.14 ADV21555.1 - 0.054 14.1 1.4 0.14 12.8 1.4 1.7 1 0 0 1 1 1 0 Protein of unknown function, DUF573 Mpp10 PF04006.12 ADV21557.1 - 4.4e-06 25.4 9.5 5e-06 25.3 9.5 1.0 1 0 0 1 1 1 1 Mpp10 protein CCDC71L PF15374.6 ADV21557.1 - 0.0053 16.1 7.7 0.006 15.9 7.7 1.1 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 71L Metal_resist PF13801.6 ADV21557.1 - 0.052 13.7 0.2 0.068 13.4 0.2 1.2 1 0 0 1 1 1 0 Heavy-metal resistance DUF892 PF05974.12 ADV21557.1 - 0.069 13.2 0.6 0.083 12.9 0.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF892) MFS_1 PF07690.16 ADV21558.1 - 4.7e-16 58.7 18.5 8.1e-16 57.9 18.5 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ADV21558.1 - 0.024 13.5 11.6 0.022 13.6 9.3 1.8 1 1 0 1 1 1 0 Sugar (and other) transporter Ribosomal_S13 PF00416.22 ADV21559.1 - 2.3e-17 63.6 0.0 7.3e-10 39.3 0.6 2.1 2 0 0 2 2 2 2 Ribosomal protein S13/S18 Prefoldin_2 PF01920.20 ADV21560.1 - 1.1e-21 76.7 3.0 1.3e-21 76.5 3.0 1.0 1 0 0 1 1 1 1 Prefoldin subunit DUF724 PF05266.14 ADV21560.1 - 0.056 13.3 0.9 0.48 10.2 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF724) ALIX_LYPXL_bnd PF13949.6 ADV21560.1 - 0.094 12.0 2.8 1 8.6 0.6 1.9 1 1 1 2 2 2 0 ALIX V-shaped domain binding to HIV Snf7 PF03357.21 ADV21560.1 - 0.14 11.8 3.5 0.11 12.1 0.5 1.9 2 0 0 2 2 2 0 Snf7 DUF4337 PF14235.6 ADV21560.1 - 0.23 11.5 2.2 0.52 10.4 0.5 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4337) Rho_Binding PF08912.11 ADV21560.1 - 0.61 10.9 7.8 2.9 8.7 0.7 2.2 2 0 0 2 2 2 0 Rho Binding Paf67 PF10255.9 ADV21561.1 - 1.8e-148 494.9 0.0 3.2e-148 494.1 0.0 1.4 2 0 0 2 2 2 1 RNA polymerase I-associated factor PAF67 TPR_2 PF07719.17 ADV21561.1 - 0.0064 16.5 0.0 0.081 13.1 0.0 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 ADV21561.1 - 0.022 14.6 0.0 0.11 12.4 0.0 2.3 1 0 0 1 1 1 0 Tetratricopeptide repeat Pkinase PF00069.25 ADV21562.1 - 1.9e-40 138.9 0.0 2.5e-40 138.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV21562.1 - 3.3e-21 75.7 0.0 5.7e-21 75.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ADV21562.1 - 1.8e-08 34.1 0.0 2.7e-07 30.2 0.0 2.1 2 0 0 2 2 2 1 Kinase-like SNF2_N PF00176.23 ADV21563.1 - 8.3e-65 218.8 0.0 3.4e-64 216.8 0.0 1.8 2 0 0 2 2 2 1 SNF2 family N-terminal domain HIRAN PF08797.11 ADV21563.1 - 1e-19 70.3 0.0 2.3e-19 69.1 0.0 1.6 1 0 0 1 1 1 1 HIRAN domain Helicase_C PF00271.31 ADV21563.1 - 1e-14 54.8 0.0 1.9e-14 53.9 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-RING_2 PF13639.6 ADV21563.1 - 2.5e-08 34.1 2.8 4.8e-08 33.2 2.8 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 ADV21563.1 - 5.6e-07 29.3 4.0 1.1e-06 28.4 4.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ADV21563.1 - 3.7e-06 26.7 2.3 3.7e-06 26.7 2.3 1.6 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ADV21563.1 - 1.7e-05 24.6 2.6 1.7e-05 24.6 2.6 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ADV21563.1 - 5.6e-05 23.0 2.1 5.6e-05 23.0 2.1 2.1 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 ADV21563.1 - 0.00014 21.8 5.5 0.00038 20.4 5.5 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.7 ADV21563.1 - 0.00018 21.7 0.9 0.00053 20.2 0.9 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 ADV21563.1 - 0.00074 19.6 4.5 0.0015 18.6 4.5 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING ResIII PF04851.15 ADV21563.1 - 0.0012 18.9 0.0 0.0053 16.8 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit zf-RING_11 PF17123.5 ADV21563.1 - 0.017 14.8 4.7 0.034 13.9 4.7 1.5 1 0 0 1 1 1 0 RING-like zinc finger zf-RING_4 PF14570.6 ADV21563.1 - 0.27 11.1 3.9 0.5 10.2 3.9 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Prok-RING_4 PF14447.6 ADV21563.1 - 0.63 10.0 4.1 1.3 9.0 4.1 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 WD40 PF00400.32 ADV21564.1 - 2.5e-43 145.2 27.2 7.4e-08 32.9 0.2 10.5 11 0 0 11 11 11 7 WD domain, G-beta repeat Utp12 PF04003.12 ADV21564.1 - 1e-20 74.0 0.2 1.7e-20 73.3 0.2 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.7 ADV21564.1 - 3.7e-17 62.4 3.1 0.007 16.6 0.0 9.1 4 2 4 9 9 9 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ADV21564.1 - 0.0001 21.1 0.1 2.4 6.7 0.0 3.5 3 0 0 3 3 3 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ADV21564.1 - 0.00023 20.2 0.4 18 4.2 0.0 5.2 2 1 4 6 6 6 2 WD40 region of Ge1, enhancer of mRNA-decapping protein AP3D1 PF06375.11 ADV21564.1 - 0.007 16.6 4.4 0.015 15.5 4.4 1.5 1 0 0 1 1 1 1 AP-3 complex subunit delta-1 Afi1 PF07792.12 ADV21564.1 - 0.25 11.8 1.6 0.32 11.5 0.0 1.9 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking ubiquitin PF00240.23 ADV21565.1 - 5.2e-05 22.9 0.2 0.00016 21.3 0.2 1.7 1 1 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.6 ADV21565.1 - 0.0058 17.1 0.2 0.024 15.1 0.2 2.0 1 1 0 1 1 1 1 Ubiquitin-like domain Gly-rich_Ago1 PF12764.7 ADV21565.1 - 0.072 13.9 0.4 0.072 13.9 0.4 2.4 3 1 0 3 3 3 0 Glycine-rich region of argonaut CDC45 PF02724.14 ADV21565.1 - 0.2 9.9 9.5 0.27 9.5 9.5 1.3 1 0 0 1 1 1 0 CDC45-like protein Hist_deacetyl PF00850.19 ADV21566.1 - 8.9e-77 258.6 0.0 1.1e-76 258.3 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain CobT PF06213.12 ADV21566.1 - 0.07 12.5 1.8 0.12 11.8 1.8 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT NOA36 PF06524.12 ADV21566.1 - 3.6 6.8 4.8 7.2 5.8 4.8 1.4 1 0 0 1 1 1 0 NOA36 protein DUF4820 PF16091.5 ADV21567.1 - 0.0075 15.7 0.5 0.0075 15.7 0.5 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4820) Radial_spoke PF04712.12 ADV21567.1 - 0.04 12.9 4.3 0.067 12.1 4.3 1.3 1 0 0 1 1 1 0 Radial spokehead-like protein PAXIP1_C PF15364.6 ADV21567.1 - 2.1 8.7 13.7 0.62 10.4 2.1 3.4 3 0 0 3 3 3 0 PAXIP1-associated-protein-1 C term PTIP binding protein CENP-B_dimeris PF09026.10 ADV21567.1 - 2.7 8.4 8.5 7.3 7.1 8.5 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Adeno_terminal PF02459.15 ADV21567.1 - 6.3 5.1 5.5 11 4.3 5.5 1.3 1 0 0 1 1 1 0 Adenoviral DNA terminal protein Ribosomal_60s PF00428.19 ADV21567.1 - 7.9 7.2 13.1 20 5.8 13.1 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein NOA36 PF06524.12 ADV21567.1 - 9 5.5 6.7 1.5 8.0 3.0 1.5 2 0 0 2 2 2 0 NOA36 protein FAM176 PF14851.6 ADV21567.1 - 9.3 5.9 9.6 0.74 9.5 4.0 2.0 2 0 0 2 2 2 0 FAM176 family HEAT_2 PF13646.6 ADV21568.1 - 6.4e-30 103.4 1.2 5.2e-15 55.6 0.0 3.2 2 1 1 3 3 3 3 HEAT repeats HEAT_PBS PF03130.16 ADV21568.1 - 1.4e-18 65.6 2.6 2.4e-05 24.6 0.1 6.5 7 0 0 7 7 7 5 PBS lyase HEAT-like repeat HEAT PF02985.22 ADV21568.1 - 1.7e-12 46.5 0.1 0.016 15.4 0.0 5.5 6 0 0 6 6 6 3 HEAT repeat HEAT_EZ PF13513.6 ADV21568.1 - 0.0019 18.7 1.7 1.7 9.2 0.1 4.2 2 2 2 4 4 4 1 HEAT-like repeat Cnd1 PF12717.7 ADV21568.1 - 0.0026 17.8 0.0 1.3 9.1 0.0 3.2 2 2 1 3 3 3 1 non-SMC mitotic condensation complex subunit 1 Arm PF00514.23 ADV21568.1 - 0.045 13.8 0.1 5.1 7.3 0.0 3.2 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat Abhydrolase_3 PF07859.13 ADV21569.1 - 2.8e-39 135.2 0.1 6.7e-31 107.8 0.0 2.7 2 0 0 2 2 2 2 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 ADV21569.1 - 2.3e-07 30.0 0.0 1.8e-06 27.1 0.0 1.9 2 0 0 2 2 2 1 Steryl acetyl hydrolase PDEase_II PF02112.15 ADV21570.1 - 2.7e-29 102.3 0.0 5.5e-28 98.0 0.0 2.2 1 1 0 1 1 1 1 cAMP phosphodiesterases class-II Lactamase_B_2 PF12706.7 ADV21570.1 - 0.082 12.4 0.1 0.21 11.1 0.1 1.8 1 1 0 1 1 1 0 Beta-lactamase superfamily domain CorA PF01544.18 ADV21574.1 - 0.13 11.6 0.3 0.19 11.0 0.3 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Prefoldin_2 PF01920.20 ADV21574.1 - 0.16 11.9 0.3 2.7 8.0 0.0 2.4 1 1 1 2 2 2 0 Prefoldin subunit PHO4 PF01384.20 ADV21575.1 - 1.6e-111 372.6 10.4 1.9e-111 372.4 10.4 1.0 1 0 0 1 1 1 1 Phosphate transporter family PLDc_2 PF13091.6 ADV21576.1 - 3.7e-23 81.9 0.1 1.1e-15 57.6 0.0 2.6 3 0 0 3 3 3 2 PLD-like domain PLDc PF00614.22 ADV21576.1 - 0.0086 16.2 0.4 0.035 14.3 0.0 2.1 2 0 0 2 2 2 1 Phospholipase D Active site motif Aminotran_5 PF00266.19 ADV21577.1 - 5.5e-33 114.4 0.0 6.8e-33 114.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 ADV21577.1 - 5.6e-05 22.5 0.0 0.00088 18.5 0.0 2.0 1 1 0 1 1 1 1 Aminotransferase class I and II Asp PF00026.23 ADV21578.1 - 1.1e-37 130.1 2.3 1.1e-37 130.1 2.3 1.8 2 0 0 2 2 2 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 ADV21578.1 - 2.8e-05 24.5 7.9 0.0035 17.6 0.1 3.0 3 0 0 3 3 3 2 Xylanase inhibitor N-terminal NIR_SIR PF01077.22 ADV21579.1 - 6.8e-55 184.9 0.0 1e-50 171.3 0.0 2.4 2 0 0 2 2 2 2 Nitrite and sulphite reductase 4Fe-4S domain NIR_SIR_ferr PF03460.17 ADV21579.1 - 5.7e-34 115.8 0.0 4e-17 61.8 0.0 2.6 2 0 0 2 2 2 2 Nitrite/Sulfite reductase ferredoxin-like half domain Flavodoxin_1 PF00258.25 ADV21579.1 - 4.1e-22 78.9 0.0 8.5e-22 77.9 0.0 1.6 1 0 0 1 1 1 1 Flavodoxin QCR10 PF09796.9 ADV21580.1 - 4.8e-27 93.8 1.1 5.5e-27 93.6 1.1 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) Ras PF00071.22 ADV21581.1 - 1.7e-65 219.5 0.8 2e-65 219.3 0.8 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ADV21581.1 - 6.6e-36 123.2 0.1 1.1e-35 122.5 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ADV21581.1 - 5.4e-17 61.8 0.1 6.8e-17 61.5 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 ADV21581.1 - 3.3e-07 30.3 1.1 0.0035 17.3 0.3 2.3 1 1 1 2 2 2 2 RsgA GTPase SRPRB PF09439.10 ADV21581.1 - 5.8e-06 25.9 0.0 7.2e-06 25.5 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 ADV21581.1 - 1.1e-05 25.1 0.3 3.1e-05 23.6 0.1 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ADV21581.1 - 1.7e-05 24.9 0.0 3.4e-05 23.9 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ADV21581.1 - 2.2e-05 23.9 0.0 2.9e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region FeoB_N PF02421.18 ADV21581.1 - 0.00059 19.4 0.0 0.0041 16.7 0.0 1.9 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA PF00004.29 ADV21581.1 - 0.0021 18.5 0.1 0.52 10.7 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ADV21581.1 - 0.016 15.6 0.0 0.026 14.9 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain TniB PF05621.11 ADV21581.1 - 0.045 13.2 0.0 0.13 11.7 0.0 1.8 2 0 0 2 2 2 0 Bacterial TniB protein AAA_29 PF13555.6 ADV21581.1 - 0.05 13.3 0.0 0.16 11.8 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.6 ADV21581.1 - 0.054 13.8 0.0 0.1 12.9 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 ADV21581.1 - 0.068 13.2 0.0 0.1 12.6 0.0 1.5 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Septin PF00735.18 ADV21581.1 - 0.076 12.3 0.0 0.17 11.1 0.0 1.5 1 0 0 1 1 1 0 Septin AAA_7 PF12775.7 ADV21581.1 - 0.08 12.4 0.0 0.19 11.2 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region ABC_tran PF00005.27 ADV21581.1 - 0.091 13.3 0.0 0.15 12.6 0.0 1.5 1 1 0 1 1 1 0 ABC transporter CDC45 PF02724.14 ADV21583.1 - 0.66 8.2 8.6 0.7 8.1 8.6 1.1 1 0 0 1 1 1 0 CDC45-like protein Pkinase PF00069.25 ADV21584.1 - 2e-62 211.0 0.0 3.7e-62 210.1 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV21584.1 - 1.1e-34 120.0 0.0 1.7e-34 119.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 ADV21584.1 - 0.025 13.5 0.0 0.16 10.9 0.0 2.0 2 0 0 2 2 2 0 Haspin like kinase domain Kinase-like PF14531.6 ADV21584.1 - 0.13 11.6 0.0 0.23 10.7 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Mpv17_PMP22 PF04117.12 ADV21585.1 - 6.9e-23 80.7 0.1 1.1e-22 80.0 0.1 1.4 1 0 0 1 1 1 1 Mpv17 / PMP22 family OSK PF17182.4 ADV21585.1 - 0.22 10.7 0.0 0.29 10.3 0.0 1.1 1 0 0 1 1 1 0 OSK domain GTP1_OBG PF01018.22 ADV21586.1 - 2.2e-26 92.3 3.6 2.5e-20 72.6 7.3 2.4 1 1 1 2 2 2 2 GTP1/OBG MMR_HSR1 PF01926.23 ADV21586.1 - 1.9e-19 69.8 0.0 3.5e-19 69.0 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ADV21586.1 - 1.1e-05 25.1 0.0 4.7e-05 23.0 0.0 1.9 2 0 0 2 2 2 1 Ferrous iron transport protein B MeaB PF03308.16 ADV21586.1 - 0.00011 21.3 0.3 0.25 10.3 0.0 2.3 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB Gtr1_RagA PF04670.12 ADV21586.1 - 0.0025 17.2 0.0 0.0043 16.4 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region cobW PF02492.19 ADV21586.1 - 0.0041 16.7 0.0 2.1 7.9 0.0 2.3 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain ABC_tran PF00005.27 ADV21586.1 - 0.0084 16.6 0.0 0.036 14.6 0.0 2.1 2 0 0 2 2 2 1 ABC transporter Dynamin_N PF00350.23 ADV21586.1 - 0.017 15.2 0.0 0.049 13.7 0.0 1.9 1 1 0 1 1 1 0 Dynamin family GTP_EFTU PF00009.27 ADV21586.1 - 0.058 12.9 0.0 1.1 8.8 0.0 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ADV21586.1 - 0.075 12.9 0.0 1.9 8.3 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase PXA PF02194.15 ADV21589.1 - 1.9e-22 80.1 0.0 3.5e-22 79.3 0.0 1.4 1 0 0 1 1 1 1 PXA domain Zn_clus PF00172.18 ADV21590.1 - 3.4e-09 36.7 10.1 5.7e-09 35.9 10.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 ADV21590.1 - 4.6e-09 35.7 0.2 8.5e-09 34.8 0.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Peptidase_M16_M PF16187.5 ADV21591.1 - 1e-82 277.6 0.9 1.8e-82 276.8 0.9 1.4 1 0 0 1 1 1 1 Middle or third domain of peptidase_M16 Peptidase_M16 PF00675.20 ADV21591.1 - 2.5e-40 137.9 0.1 2e-39 135.0 0.0 2.3 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 ADV21591.1 - 1.2e-30 106.9 0.0 1.6e-17 64.1 0.0 2.6 2 0 0 2 2 2 2 Peptidase M16 inactive domain Tmemb_170 PF10190.9 ADV21593.1 - 2.1e-09 37.7 5.4 2.1e-09 37.7 5.4 2.1 2 0 0 2 2 2 2 Putative transmembrane protein 170 Carn_acyltransf PF00755.20 ADV21594.1 - 2.8e-154 515.0 0.0 2.2e-153 512.0 0.0 1.9 1 1 0 1 1 1 1 Choline/Carnitine o-acyltransferase DUF5476 PF17570.2 ADV21594.1 - 0.1 13.0 0.1 0.4 11.1 0.1 2.0 1 0 0 1 1 1 0 Family of unknown function (DUF5476) Baculo_IE-1 PF05290.11 ADV21594.1 - 0.13 12.2 0.0 0.28 11.1 0.0 1.4 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) Fer4 PF00037.27 ADV21595.1 - 1.1e-13 50.3 17.3 3.2e-08 33.1 4.4 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.7 ADV21595.1 - 1.3e-11 44.9 11.0 2.1e-11 44.2 11.0 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_16 PF13484.6 ADV21595.1 - 7.2e-10 39.7 9.6 2.5e-05 25.1 0.9 2.4 2 1 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_21 PF14697.6 ADV21595.1 - 4.4e-09 36.3 6.8 0.00026 21.1 0.4 2.3 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 ADV21595.1 - 1.5e-08 34.6 10.4 0.00025 21.1 1.5 2.3 2 1 0 2 2 2 2 4Fe-4S dicluster domain Fer4_8 PF13183.6 ADV21595.1 - 6.5e-08 32.9 19.4 5.8e-05 23.5 11.1 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.6 ADV21595.1 - 6.7e-08 32.6 11.3 1.3e-07 31.6 11.2 1.5 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_6 PF12837.7 ADV21595.1 - 5.8e-07 29.3 17.8 0.00051 20.0 5.4 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_2 PF12797.7 ADV21595.1 - 3.8e-06 26.7 12.4 0.0076 16.3 2.1 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_4 PF12800.7 ADV21595.1 - 8.2e-06 25.9 11.0 0.00039 20.7 1.9 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.6 ADV21595.1 - 0.00012 22.5 11.9 0.00069 20.1 12.4 2.0 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_13 PF13370.6 ADV21595.1 - 0.002 18.6 11.3 0.23 12.0 1.0 2.5 2 0 0 2 2 2 2 4Fe-4S single cluster domain of Ferredoxin I Fer4_22 PF17179.4 ADV21595.1 - 0.069 14.0 12.2 1.4 9.9 2.9 2.3 1 1 2 3 3 3 0 4Fe-4S dicluster domain Fer4_18 PF13746.6 ADV21595.1 - 0.076 13.2 9.6 0.87 9.8 1.1 2.3 1 1 1 2 2 2 0 4Fe-4S dicluster domain c-SKI_SMAD_bind PF08782.10 ADV21595.1 - 0.24 11.7 5.9 0.35 11.1 0.3 2.3 1 1 1 2 2 2 0 c-SKI Smad4 binding domain Fer4_3 PF12798.7 ADV21595.1 - 0.27 12.3 16.3 0.45 11.6 4.1 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain ETF_QO PF05187.13 ADV21595.1 - 0.5 10.5 3.3 1.8 8.7 0.1 2.4 2 0 0 2 2 2 0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S EPF PF17181.4 ADV21595.1 - 4.2 7.4 7.7 0.96 9.5 1.4 2.3 2 0 0 2 2 2 0 Epidermal patterning factor proteins MscS_porin PF12795.7 ADV21596.1 - 0.00071 19.2 2.0 0.00071 19.2 2.0 1.9 2 0 0 2 2 2 1 Mechanosensitive ion channel porin domain APG6_N PF17675.1 ADV21596.1 - 0.0014 19.1 1.5 0.0022 18.5 1.5 1.2 1 0 0 1 1 1 1 Apg6 coiled-coil region Prefoldin PF02996.17 ADV21596.1 - 0.0038 17.1 1.1 0.0063 16.4 1.1 1.2 1 0 0 1 1 1 1 Prefoldin subunit DHR10 PF18595.1 ADV21596.1 - 0.0045 17.0 3.5 0.0065 16.5 3.5 1.2 1 0 0 1 1 1 1 Designed helical repeat protein 10 domain XhlA PF10779.9 ADV21596.1 - 0.0065 16.6 1.1 0.0096 16.1 1.1 1.2 1 0 0 1 1 1 1 Haemolysin XhlA FlaC_arch PF05377.11 ADV21596.1 - 0.013 15.8 0.6 0.022 15.2 0.6 1.3 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) Spc24 PF08286.11 ADV21596.1 - 0.017 15.3 1.0 0.027 14.7 1.0 1.2 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 CLZ PF16526.5 ADV21596.1 - 0.019 15.3 1.4 0.029 14.7 1.4 1.2 1 0 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Spc7 PF08317.11 ADV21596.1 - 0.027 13.4 2.1 0.038 12.9 2.1 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Phage_GP20 PF06810.11 ADV21596.1 - 0.027 14.3 0.5 0.039 13.8 0.5 1.1 1 0 0 1 1 1 0 Phage minor structural protein GP20 TMF_DNA_bd PF12329.8 ADV21596.1 - 0.04 13.9 1.9 0.065 13.2 1.9 1.3 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding DUF4618 PF15397.6 ADV21596.1 - 0.055 12.9 0.2 0.077 12.4 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) Csm1_N PF18504.1 ADV21596.1 - 0.08 13.3 3.0 0.13 12.6 3.0 1.3 1 0 0 1 1 1 0 Csm1 N-terminal domain Prefoldin_2 PF01920.20 ADV21596.1 - 0.096 12.7 2.6 0.14 12.1 2.6 1.2 1 0 0 1 1 1 0 Prefoldin subunit DUF724 PF05266.14 ADV21596.1 - 0.11 12.3 0.7 0.16 11.8 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DUF16 PF01519.16 ADV21596.1 - 0.12 12.9 0.8 0.19 12.3 0.8 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF16 SlyX PF04102.12 ADV21596.1 - 0.15 12.7 2.8 0.3 11.7 2.8 1.5 1 0 0 1 1 1 0 SlyX DUF2730 PF10805.8 ADV21596.1 - 0.2 11.8 0.4 0.31 11.1 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) ABC_tran_CTD PF16326.5 ADV21596.1 - 0.23 11.8 3.8 0.37 11.1 3.5 1.5 1 1 0 1 1 1 0 ABC transporter C-terminal domain DUF4140 PF13600.6 ADV21596.1 - 0.23 11.9 4.0 0.36 11.3 4.0 1.6 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) DP PF08781.10 ADV21596.1 - 0.78 9.6 4.2 0.47 10.4 1.6 1.8 2 0 0 2 2 2 0 Transcription factor DP Secretin_N_2 PF07655.13 ADV21597.1 - 0.56 10.8 12.2 0.15 12.7 3.0 2.3 2 0 0 2 2 2 0 Secretin N-terminal domain DUF4381 PF14316.6 ADV21598.1 - 0.002 18.4 0.3 0.002 18.4 0.3 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4381) UQ_con PF00179.26 ADV21599.1 - 1.1e-21 77.0 0.0 1.7e-20 73.1 0.0 2.4 2 0 0 2 2 2 1 Ubiquitin-conjugating enzyme TSC22 PF01166.18 ADV21599.1 - 0.12 12.8 1.8 0.39 11.1 1.8 1.9 1 0 0 1 1 1 0 TSC-22/dip/bun family IBR PF01485.21 ADV21599.1 - 0.13 12.5 2.1 0.3 11.3 2.1 1.6 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain RXT2_N PF08595.11 ADV21599.1 - 8.4 6.4 9.5 2.2 8.3 5.9 1.9 2 0 0 2 2 2 0 RXT2-like, N-terminal CoA_trans PF01144.23 ADV21601.1 - 3.1e-98 327.5 4.7 4.2e-61 206.1 0.1 2.1 2 0 0 2 2 2 2 Coenzyme A transferase AcetylCoA_hyd_C PF13336.6 ADV21601.1 - 0.00046 20.2 0.1 0.00091 19.2 0.1 1.5 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase C-terminal domain Mal_decarbox_Al PF16957.5 ADV21601.1 - 0.054 11.8 0.1 0.082 11.2 0.1 1.2 1 0 0 1 1 1 0 Malonate decarboxylase, alpha subunit, transporter Aldedh PF00171.22 ADV21602.1 - 2e-110 369.5 0.0 2.4e-110 369.2 0.0 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Lipase_GDSL_2 PF13472.6 ADV21603.1 - 4e-19 69.7 0.0 5e-19 69.4 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 ADV21603.1 - 2.9e-14 53.5 0.0 5.1e-14 52.7 0.0 1.4 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Hexapep PF00132.24 ADV21604.1 - 2.4e-11 42.9 4.2 3.2e-08 33.0 1.2 3.6 4 0 0 4 4 4 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 ADV21604.1 - 9.1e-11 41.3 5.6 1.4e-07 31.1 0.9 3.9 4 0 0 4 4 4 2 Hexapeptide repeat of succinyl-transferase DUF1349 PF07081.11 ADV21605.1 - 2.3e-14 53.5 0.0 3.6e-14 52.9 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1349) Oxysterol_BP PF01237.18 ADV21606.1 - 1.5e-41 142.5 3.0 4.3e-25 88.4 3.1 3.1 2 1 0 2 2 2 2 Oxysterol-binding protein ParD_antitoxin PF03693.14 ADV21606.1 - 0.053 13.9 0.0 0.16 12.4 0.0 1.8 2 0 0 2 2 2 0 Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH RNA_pol_3_Rpc31 PF11705.8 ADV21607.1 - 4.5e-24 86.0 6.1 9.9e-24 84.8 6.1 1.5 1 1 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 PPR PF01535.20 ADV21608.1 - 3.9e-09 36.2 3.9 0.77 10.1 0.0 7.1 7 0 0 7 7 7 1 PPR repeat PPR_2 PF13041.6 ADV21608.1 - 1.9e-05 24.8 5.5 1.6 9.0 0.0 7.0 7 3 2 9 9 9 2 PPR repeat family PPR_3 PF13812.6 ADV21608.1 - 0.0002 21.3 0.1 3.7 7.7 0.0 4.6 4 1 0 4 4 4 1 Pentatricopeptide repeat domain TPR_19 PF14559.6 ADV21608.1 - 0.00042 20.8 5.5 0.4 11.2 0.0 4.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 ADV21608.1 - 0.16 12.9 0.1 0.16 12.9 0.1 6.7 6 1 1 7 7 7 0 Tetratricopeptide repeat TPR_10 PF13374.6 ADV21608.1 - 0.22 11.5 2.2 36 4.4 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.6 ADV21608.1 - 0.32 11.7 6.2 0.42 11.3 0.0 4.0 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 ADV21608.1 - 4.1 7.8 5.1 37 4.7 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat RVT_2 PF07727.14 ADV21609.1 - 5.7e-19 68.7 0.0 1.3e-18 67.6 0.0 1.5 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Abhydrolase_1 PF00561.20 ADV21610.1 - 3e-40 138.5 0.0 4.2e-39 134.7 0.0 2.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_4 PF08386.10 ADV21610.1 - 0.039 14.1 0.0 0.13 12.4 0.0 1.9 2 0 0 2 2 2 0 TAP-like protein Hydrolase_4 PF12146.8 ADV21610.1 - 0.15 11.3 0.0 0.39 9.9 0.0 1.6 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ADV21610.1 - 0.23 12.0 3.4 1.2 9.7 3.4 2.0 1 1 0 1 1 1 0 Alpha/beta hydrolase family RHD3 PF05879.12 ADV21611.1 - 2.4e-242 806.3 0.4 1.9e-241 803.3 0.4 1.9 1 1 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) GBP PF02263.19 ADV21611.1 - 7.5e-06 25.4 0.1 1.4e-05 24.5 0.1 1.4 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain MMR_HSR1 PF01926.23 ADV21611.1 - 1.2e-05 25.4 0.0 4.1e-05 23.6 0.0 2.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 ADV21611.1 - 3.3e-05 24.0 0.0 7e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 Dynamin family AAA_28 PF13521.6 ADV21611.1 - 0.0028 17.9 0.0 0.0088 16.3 0.0 1.9 1 0 0 1 1 1 1 AAA domain Roc PF08477.13 ADV21611.1 - 0.14 12.4 0.7 0.44 10.8 0.1 2.1 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase MDD_C PF18376.1 ADV21612.1 - 9.1e-71 237.5 0.0 1.2e-70 237.1 0.0 1.1 1 0 0 1 1 1 1 Mevalonate 5-diphosphate decarboxylase C-terminal domain GHMP_kinases_N PF00288.26 ADV21612.1 - 9.9e-08 32.1 6.4 2e-07 31.2 6.4 1.5 1 0 0 1 1 1 1 GHMP kinases N terminal domain UreF PF01730.16 ADV21612.1 - 0.011 16.4 0.0 0.22 12.1 0.0 2.2 1 1 1 2 2 2 0 UreF JmjN PF02375.17 ADV21612.1 - 0.22 11.5 0.4 0.52 10.3 0.4 1.6 1 0 0 1 1 1 0 jmjN domain Rtf2 PF04641.12 ADV21614.1 - 3.3e-82 275.8 0.1 3.8e-82 275.6 0.1 1.0 1 0 0 1 1 1 1 Rtf2 RING-finger zf-C2HC_2 PF13913.6 ADV21614.1 - 0.0077 16.1 0.5 0.019 14.8 0.5 1.7 1 0 0 1 1 1 1 zinc-finger of a C2HC-type DUF1610 PF07754.11 ADV21614.1 - 0.011 15.7 0.6 0.011 15.7 0.6 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF1610) zf-NOSIP PF15906.5 ADV21614.1 - 0.011 15.9 0.0 0.023 14.8 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein zf-Nse PF11789.8 ADV21614.1 - 0.013 15.3 0.1 2 8.3 0.1 2.5 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit ADK_lid PF05191.14 ADV21614.1 - 0.022 14.8 0.1 0.12 12.4 0.0 2.3 2 0 0 2 2 2 0 Adenylate kinase, active site lid CpXC PF14353.6 ADV21614.1 - 0.031 14.3 0.0 0.07 13.2 0.0 1.6 1 0 0 1 1 1 0 CpXC protein zinc_ribbon_4 PF13717.6 ADV21614.1 - 0.031 14.2 0.1 0.072 13.0 0.1 1.6 1 0 0 1 1 1 0 zinc-ribbon domain NUDIX_5 PF16705.5 ADV21614.1 - 0.074 12.8 0.1 0.2 11.4 0.1 1.7 1 0 0 1 1 1 0 NUDIX, or N-terminal NPxY motif-rich, region of KRIT zf-HYPF PF07503.12 ADV21614.1 - 0.92 9.3 3.0 8.9 6.2 0.4 2.5 2 0 0 2 2 2 0 HypF finger MFS_1 PF07690.16 ADV21615.1 - 4.1e-29 101.6 16.7 1.1e-28 100.3 16.4 1.9 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ADV21615.1 - 0.018 14.0 13.1 2.2 7.1 0.4 3.8 3 1 0 3 3 3 0 Sugar (and other) transporter LapA_dom PF06305.11 ADV21615.1 - 0.061 13.1 0.1 3 7.7 0.0 2.9 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain OATP PF03137.20 ADV21615.1 - 0.71 8.1 5.4 1.2 7.3 1.1 2.3 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family HMG_box PF00505.19 ADV21616.1 - 1.1e-14 54.6 5.2 4.4e-09 36.6 1.0 2.8 2 2 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.10 ADV21616.1 - 8.2e-09 35.9 1.6 0.0022 18.5 0.2 2.6 2 1 1 3 3 3 2 HMG-box domain Protamine_like PF06382.11 ADV21616.1 - 0.47 10.6 4.4 21 5.3 1.9 2.9 1 1 1 2 2 2 0 Protamine and protamine like Aminotran_3 PF00202.21 ADV21618.1 - 2.1e-118 395.5 0.0 2.5e-118 395.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 ADV21618.1 - 0.015 14.5 0.0 0.021 14.0 0.0 1.1 1 0 0 1 1 1 0 Aminotransferase class I and II OAM_dimer PF16554.5 ADV21618.1 - 0.056 13.9 0.0 0.12 12.9 0.0 1.5 1 0 0 1 1 1 0 Dimerisation domain of d-ornithine 4,5-aminomutase Beta_elim_lyase PF01212.21 ADV21618.1 - 0.2 10.9 0.0 0.38 10.0 0.0 1.3 1 0 0 1 1 1 0 Beta-eliminating lyase ER_lumen_recept PF00810.18 ADV21619.1 - 1.2e-53 181.9 7.2 1.6e-53 181.5 7.2 1.2 1 0 0 1 1 1 1 ER lumen protein retaining receptor PQ-loop PF04193.14 ADV21619.1 - 0.0016 18.1 7.9 0.19 11.5 0.2 4.3 4 1 1 5 5 5 3 PQ loop repeat MTHFR PF02219.17 ADV21620.1 - 1.1e-102 343.3 0.0 1.4e-102 342.9 0.0 1.1 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase Mg_trans_NIPA PF05653.14 ADV21621.1 - 7.1e-22 77.9 13.4 3.3e-11 42.8 4.6 2.1 2 0 0 2 2 2 2 Magnesium transporter NIPA EamA PF00892.20 ADV21621.1 - 0.0044 17.2 6.4 0.0044 17.2 6.4 3.3 3 1 0 3 3 3 1 EamA-like transporter family Pro_CA PF00484.19 ADV21622.1 - 1.5e-36 126.1 0.0 2.1e-36 125.6 0.0 1.2 1 0 0 1 1 1 1 Carbonic anhydrase AAA_12 PF13087.6 ADV21623.1 - 1.6e-56 191.1 0.0 3.2e-56 190.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 ADV21623.1 - 9.3e-48 163.3 0.0 1.8e-47 162.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 ADV21623.1 - 1e-13 51.8 0.1 2.8e-13 50.4 0.1 1.8 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 ADV21623.1 - 6.1e-12 45.7 0.0 1.1e-10 41.5 0.0 2.5 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 ADV21623.1 - 5.2e-05 23.1 0.0 1.7 8.3 0.0 3.3 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase UvrD-helicase PF00580.21 ADV21623.1 - 0.00037 20.1 0.1 0.0014 18.2 0.1 2.0 1 1 1 2 2 2 1 UvrD/REP helicase N-terminal domain PIF1 PF05970.14 ADV21623.1 - 0.0068 15.6 0.0 1.1 8.3 0.0 2.4 2 0 0 2 2 2 1 PIF1-like helicase ResIII PF04851.15 ADV21623.1 - 0.0073 16.3 0.1 0.024 14.6 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_16 PF13191.6 ADV21623.1 - 0.12 12.8 0.0 0.38 11.1 0.0 1.9 1 0 0 1 1 1 0 AAA ATPase domain PhoH PF02562.16 ADV21623.1 - 0.15 11.5 0.0 0.66 9.4 0.0 2.0 2 0 0 2 2 2 0 PhoH-like protein AAA_25 PF13481.6 ADV21623.1 - 0.15 11.6 0.0 0.56 9.8 0.0 1.9 2 0 0 2 2 2 0 AAA domain Ribosomal_L31 PF01197.18 ADV21623.1 - 0.18 12.0 0.0 0.72 10.1 0.0 2.0 2 0 0 2 2 1 0 Ribosomal protein L31 Glyco_transf_90 PF05686.12 ADV21624.1 - 2e-12 46.8 0.4 6.9e-12 45.0 0.4 1.8 1 1 0 1 1 1 1 Glycosyl transferase family 90 Ribosomal_L9_C PF03948.14 ADV21624.1 - 0.13 12.7 0.0 8.9 6.9 0.0 2.3 2 0 0 2 2 2 0 Ribosomal protein L9, C-terminal domain Utp11 PF03998.13 ADV21625.1 - 1.2e-65 221.9 19.8 1.5e-65 221.6 19.8 1.1 1 0 0 1 1 1 1 Utp11 protein LCAT PF02450.15 ADV21626.1 - 5.9e-72 243.0 0.1 8e-71 239.3 0.1 2.0 1 1 0 1 1 1 1 Lecithin:cholesterol acyltransferase GATA PF00320.27 ADV21627.1 - 8.6e-07 28.5 6.0 1.6e-06 27.6 6.0 1.5 1 0 0 1 1 1 1 GATA zinc finger HscB_4_cys PF18256.1 ADV21627.1 - 0.26 11.1 1.8 0.74 9.7 1.8 1.8 1 0 0 1 1 1 0 Co-chaperone HscB tetracysteine metal binding motif AT_hook PF02178.19 ADV21627.1 - 0.26 11.3 18.6 0.63 10.1 0.8 4.0 3 0 0 3 3 3 0 AT hook motif VIT1 PF01988.19 ADV21628.1 - 2e-62 210.8 3.4 2.5e-62 210.6 3.4 1.1 1 0 0 1 1 1 1 VIT family YesK PF14150.6 ADV21628.1 - 0.82 9.9 7.1 1.8 8.8 7.1 1.6 1 0 0 1 1 1 0 YesK-like protein Hirudin PF00713.17 ADV21630.1 - 0.19 12.1 2.6 0.26 11.6 1.9 1.6 1 1 0 1 1 1 0 Hirudin DUF3384 PF11864.8 ADV21633.1 - 0.062 12.2 0.0 0.073 12.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3384) Yip1 PF04893.17 ADV21633.1 - 1.6 8.4 12.8 0.35 10.6 2.8 3.1 3 0 0 3 3 3 0 Yip1 domain TMEM239 PF15841.5 ADV21633.1 - 9.4 6.1 11.0 0.96 9.3 3.0 2.5 2 0 0 2 2 2 0 Transmembrane protein 239 family RNB PF00773.19 ADV21634.1 - 5.1e-68 229.8 0.0 4.7e-67 226.6 0.0 2.1 1 1 0 1 1 1 1 RNB domain SNF2_N PF00176.23 ADV21635.1 - 1.2e-60 205.1 0.3 2e-60 204.4 0.3 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ADV21635.1 - 9.5e-19 67.8 0.0 4.8e-18 65.5 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ADV21635.1 - 7.7e-12 45.5 0.0 1.6e-11 44.5 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 ADV21635.1 - 4.4e-05 23.3 0.0 0.00012 21.9 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase DEAD_2 PF06733.15 ADV21635.1 - 0.21 11.2 0.0 0.41 10.3 0.0 1.3 1 0 0 1 1 1 0 DEAD_2 FMN_dh PF01070.18 ADV21637.1 - 3.9e-115 384.6 0.1 4.6e-115 384.4 0.1 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 ADV21637.1 - 9.3e-20 70.6 0.1 2.3e-19 69.3 0.1 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.17 ADV21637.1 - 1e-07 31.4 0.1 1.6e-07 30.9 0.1 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 ADV21637.1 - 0.0005 19.2 0.0 0.001 18.2 0.0 1.4 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.15 ADV21637.1 - 0.069 12.5 0.1 0.098 12.0 0.1 1.2 1 0 0 1 1 1 0 Nitronate monooxygenase Glu_syn_central PF04898.14 ADV21637.1 - 0.072 12.6 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 Glutamate synthase central domain DHO_dh PF01180.21 ADV21637.1 - 0.083 12.1 0.0 0.18 11.0 0.0 1.5 1 0 0 1 1 1 0 Dihydroorotate dehydrogenase Zn_clus PF00172.18 ADV21638.1 - 1.5e-08 34.6 16.0 1.1e-07 31.8 12.8 2.5 2 0 0 2 2 2 2 Fungal Zn(2)-Cys(6) binuclear cluster domain Myosin_head PF00063.21 ADV21639.1 - 5.6e-239 794.9 0.2 6.8e-239 794.6 0.2 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 ADV21639.1 - 1.6e-53 181.2 0.0 3.7e-53 180.0 0.0 1.7 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding SH3_1 PF00018.28 ADV21639.1 - 4.2e-09 35.9 0.7 8.3e-09 34.9 0.7 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ADV21639.1 - 8.4e-08 32.0 0.2 2.4e-07 30.5 0.2 1.9 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 ADV21639.1 - 1.1e-06 28.2 0.2 2.7e-06 27.0 0.2 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 ADV21639.1 - 0.00044 20.5 1.1 0.00089 19.5 1.1 1.5 1 0 0 1 1 1 1 Bacterial SH3 domain IQ PF00612.27 ADV21639.1 - 0.003 17.2 10.4 0.11 12.3 0.5 3.0 1 1 1 2 2 2 2 IQ calmodulin-binding motif AAA_16 PF13191.6 ADV21639.1 - 0.014 15.8 0.0 0.045 14.1 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 ADV21639.1 - 0.033 14.5 0.2 0.13 12.6 0.2 2.0 1 0 0 1 1 1 0 AAA domain Hpr_kinase_C PF07475.12 ADV21639.1 - 0.095 12.2 0.2 8.7 5.8 0.0 2.5 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain NACHT PF05729.12 ADV21639.1 - 0.13 12.2 0.9 0.42 10.5 0.1 2.1 2 0 0 2 2 2 0 NACHT domain AAA_16 PF13191.6 ADV21640.1 - 0.00065 20.1 0.0 0.0041 17.5 0.0 2.2 2 1 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 ADV21640.1 - 0.03 14.1 0.0 0.056 13.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_7 PF12775.7 ADV21640.1 - 0.23 10.9 0.0 0.37 10.3 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region Homeodomain PF00046.29 ADV21641.1 - 2.4e-13 49.7 3.2 5.1e-13 48.6 3.2 1.6 1 0 0 1 1 1 1 Homeodomain Mito_carr PF00153.27 ADV21642.1 - 2.9e-29 100.9 0.3 6.6e-12 45.2 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein FHA PF00498.26 ADV21643.1 - 3.4e-06 27.3 0.0 8.1e-06 26.1 0.0 1.7 1 0 0 1 1 1 1 FHA domain PAS_9 PF13426.7 ADV21644.1 - 1.2e-26 93.0 0.0 1.5e-15 57.3 0.0 3.5 3 0 0 3 3 3 3 PAS domain PAS_3 PF08447.12 ADV21644.1 - 1.7e-16 60.2 0.0 7.9e-12 45.3 0.0 4.2 4 0 0 4 4 4 2 PAS fold PAS PF00989.25 ADV21644.1 - 1.4e-15 57.3 0.0 1.3e-07 31.6 0.0 3.8 3 0 0 3 3 3 3 PAS fold PAS_4 PF08448.10 ADV21644.1 - 2.7e-06 27.6 0.0 0.019 15.2 0.0 3.5 3 0 0 3 3 3 2 PAS fold PAS_11 PF14598.6 ADV21644.1 - 0.00094 19.3 0.0 0.0027 17.8 0.0 1.7 2 0 0 2 2 2 1 PAS domain Peptidase_M48 PF01435.18 ADV21645.1 - 5.7e-18 65.4 0.0 2.2e-17 63.5 0.0 1.8 1 1 0 1 1 1 1 Peptidase family M48 Glyco_transf_8 PF01501.20 ADV21646.1 - 2.5e-07 30.5 0.1 5.3e-07 29.4 0.1 1.4 1 1 0 1 1 1 1 Glycosyl transferase family 8 Nucleotid_trans PF03407.16 ADV21646.1 - 0.007 16.4 0.1 0.01 15.9 0.1 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase zf-GRF PF06839.12 ADV21647.1 - 6.8e-06 26.1 0.4 1.2e-05 25.3 0.4 1.3 1 0 0 1 1 1 1 GRF zinc finger bZIP_2 PF07716.15 ADV21647.1 - 0.011 15.8 2.9 0.011 15.8 1.4 1.8 1 1 1 2 2 2 0 Basic region leucine zipper Macoilin PF09726.9 ADV21647.1 - 0.12 11.0 0.2 0.13 10.8 0.2 1.1 1 0 0 1 1 1 0 Macoilin family SlyX PF04102.12 ADV21647.1 - 1.8 9.3 10.9 0.16 12.6 3.0 2.9 2 2 0 2 2 2 0 SlyX DUF3437 PF11919.8 ADV21649.1 - 0.25 11.3 1.0 0.76 9.7 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3437) ABA_GPCR PF12430.8 ADV21650.1 - 1.3e-45 155.4 0.3 1.3e-45 155.4 0.3 1.9 2 0 0 2 2 2 1 Abscisic acid G-protein coupled receptor GPHR_N PF12537.8 ADV21650.1 - 4.6e-16 58.7 0.0 1.4e-15 57.1 0.0 1.9 1 0 0 1 1 1 1 The Golgi pH Regulator (GPHR) Family N-terminal EMP70 PF02990.16 ADV21650.1 - 0.15 10.7 1.9 0.29 9.7 1.9 1.4 1 0 0 1 1 1 0 Endomembrane protein 70 Sad1_UNC PF07738.13 ADV21651.1 - 2e-15 57.0 0.0 3.5e-15 56.2 0.0 1.4 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal Atg14 PF10186.9 ADV21651.1 - 1 8.4 15.1 0.44 9.6 0.0 2.7 2 1 0 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 Tox-ODYAM1 PF15642.6 ADV21651.1 - 7.3 5.5 10.4 2 7.3 0.2 2.1 2 0 0 2 2 2 0 Toxin in Odyssella and Amoebophilus Glyco_transf_8 PF01501.20 ADV21652.1 - 0.0072 15.9 0.0 0.021 14.4 0.0 1.6 2 0 0 2 2 2 1 Glycosyl transferase family 8 GAS2 PF02187.17 ADV21653.1 - 1.1e-10 41.4 0.2 2.9e-10 40.1 0.2 1.6 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain EntA_Immun PF08951.10 ADV21653.1 - 0.83 10.1 3.1 51 4.3 0.0 3.7 3 0 0 3 3 3 0 Enterocin A Immunity CHDCT2 PF08074.11 ADV21653.1 - 2.2 8.4 5.3 8.2 6.6 0.0 3.2 3 0 0 3 3 3 0 CHDCT2 (NUC038) domain Peptidase_M16 PF00675.20 ADV21654.1 - 3.3e-20 72.6 0.2 5.5e-20 71.9 0.2 1.4 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 ADV21654.1 - 1.5e-08 34.9 0.0 2.4e-08 34.2 0.0 1.3 1 0 0 1 1 1 1 Peptidase M16 inactive domain IMS PF00817.20 ADV21655.1 - 1.7e-42 145.0 0.5 3.5e-42 143.9 0.5 1.6 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 ADV21655.1 - 5.4e-16 59.3 2.4 3.1e-15 56.9 0.9 2.6 1 1 1 2 2 2 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 ADV21655.1 - 9.4e-05 22.5 0.0 0.00023 21.3 0.0 1.7 1 0 0 1 1 1 1 IMS family HHH motif Imm30 PF15565.6 ADV21655.1 - 0.027 14.5 0.0 0.058 13.5 0.0 1.5 1 0 0 1 1 1 0 Immunity protein 30 Kinesin PF00225.23 ADV21656.1 - 4.2e-100 334.9 4.0 7.7e-100 334.1 0.0 3.0 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 ADV21656.1 - 2.8e-21 76.0 0.0 2.8e-21 76.0 0.0 3.2 4 0 0 4 4 4 1 Microtubule binding MqsA_antitoxin PF15731.5 ADV21656.1 - 3.9 7.6 6.0 1.5 8.9 0.6 3.4 3 0 0 3 3 3 0 Antitoxin component of bacterial toxin-antitoxin system, MqsA HhH-GPD PF00730.25 ADV21657.1 - 1.2e-12 48.2 0.0 2.2e-12 47.4 0.0 1.4 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein CAF1 PF04857.20 ADV21658.1 - 1.7e-21 76.7 0.2 7.7e-12 45.0 0.0 2.7 2 1 0 2 2 2 2 CAF1 family ribonuclease Use1 PF09753.9 ADV21659.1 - 8.2e-11 42.1 0.0 1.3e-10 41.4 0.0 1.5 1 0 0 1 1 1 1 Membrane fusion protein Use1 KELK PF15796.5 ADV21659.1 - 0.087 13.3 1.2 0.18 12.3 1.2 1.4 1 0 0 1 1 1 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase RRM_1 PF00076.22 ADV21660.1 - 1.6e-35 120.7 0.0 2.2e-18 65.8 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ADV21660.1 - 0.00081 19.5 0.0 0.0023 18.0 0.0 1.7 2 0 0 2 2 2 1 RNA recognition motif RRM_5 PF13893.6 ADV21660.1 - 0.00086 18.9 0.0 0.99 9.0 0.0 2.3 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 ADV21660.1 - 0.087 12.9 0.0 12 6.1 0.0 2.5 2 0 0 2 2 2 0 Limkain b1 F-box-like PF12937.7 ADV21661.1 - 0.0021 17.9 0.1 0.0051 16.7 0.1 1.6 1 0 0 1 1 1 1 F-box-like YyzF PF14116.6 ADV21661.1 - 0.062 13.3 0.0 0.19 11.8 0.0 1.8 1 0 0 1 1 1 0 YyzF-like protein CFEM PF05730.11 ADV21662.1 - 4.1e-11 42.8 10.0 1.1e-10 41.5 10.0 1.8 1 0 0 1 1 1 1 CFEM domain FAM196 PF15265.6 ADV21662.1 - 1.3 8.4 24.3 1.5 8.2 24.3 1.1 1 0 0 1 1 1 0 FAM196 family Y_phosphatase PF00102.27 ADV21663.1 - 2.2e-57 194.4 0.0 4.1e-51 173.8 0.0 3.1 2 1 0 2 2 2 2 Protein-tyrosine phosphatase Rhodanese PF00581.20 ADV21663.1 - 4.2e-06 27.2 0.0 8.9e-06 26.2 0.0 1.6 1 0 0 1 1 1 1 Rhodanese-like domain DSPc PF00782.20 ADV21663.1 - 0.013 15.3 0.1 0.025 14.4 0.1 1.4 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 ADV21663.1 - 0.048 13.6 0.0 0.094 12.7 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family ABC_membrane PF00664.23 ADV21664.1 - 5.2e-51 173.9 0.0 7.4e-51 173.4 0.0 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 ADV21664.1 - 9.5e-32 110.4 0.0 1.8e-31 109.5 0.0 1.5 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ADV21664.1 - 4.2e-05 23.1 1.0 0.00089 18.7 0.1 2.2 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.9 ADV21664.1 - 0.0035 16.2 0.1 0.0061 15.4 0.1 1.4 1 0 0 1 1 1 1 Predicted ATPase of the ABC class Zeta_toxin PF06414.12 ADV21664.1 - 0.0038 16.5 0.0 0.0084 15.4 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin AAA PF00004.29 ADV21664.1 - 0.029 14.8 0.1 0.12 12.8 0.1 1.9 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 ADV21664.1 - 0.048 13.4 0.2 0.14 11.9 0.2 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain UbiA PF01040.18 ADV21665.1 - 5.7e-52 176.5 20.3 8.3e-52 176.0 20.3 1.2 1 0 0 1 1 1 1 UbiA prenyltransferase family SID-1_RNA_chan PF13965.6 ADV21665.1 - 0.065 11.6 0.0 0.087 11.2 0.0 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 ALG3 PF05208.13 ADV21666.1 - 8.1e-126 420.3 9.9 9.6e-126 420.0 9.9 1.0 1 0 0 1 1 1 1 ALG3 protein Nuc_sug_transp PF04142.15 ADV21667.1 - 1.4e-90 303.7 4.5 1.9e-80 270.4 2.1 2.1 2 0 0 2 2 2 2 Nucleotide-sugar transporter UAA PF08449.11 ADV21667.1 - 1.8e-07 30.7 5.3 3.1e-07 29.9 5.3 1.4 1 0 0 1 1 1 1 UAA transporter family PUNUT PF16913.5 ADV21667.1 - 0.00017 21.0 1.5 0.00017 21.0 1.5 1.8 2 0 0 2 2 2 1 Purine nucleobase transmembrane transport EamA PF00892.20 ADV21667.1 - 0.0015 18.7 2.5 0.0015 18.7 2.5 3.1 3 1 0 3 3 3 1 EamA-like transporter family TPT PF03151.16 ADV21667.1 - 0.63 9.3 12.6 0.33 10.3 1.0 2.7 2 1 0 2 2 2 0 Triose-phosphate Transporter family Cellulase PF00150.18 ADV21668.1 - 5e-09 36.0 1.7 1.1e-08 34.9 1.7 1.5 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) RskA PF10099.9 ADV21668.1 - 0.0057 17.0 0.3 0.012 15.9 0.3 1.5 1 0 0 1 1 1 1 Anti-sigma-K factor rskA E1-E2_ATPase PF00122.20 ADV21669.1 - 4.9e-23 81.6 0.0 1.2e-22 80.3 0.0 1.7 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 ADV21669.1 - 2.4e-18 67.2 0.0 5.5e-11 43.2 0.0 2.6 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ADV21669.1 - 0.0006 19.9 0.0 0.0012 18.8 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 ADV21669.1 - 0.021 14.5 0.0 0.048 13.4 0.0 1.5 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 ADV21670.1 - 1.5e-47 161.5 0.8 3e-47 160.5 0.0 2.0 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 ADV21670.1 - 9.4e-39 133.0 2.0 9.4e-39 133.0 2.0 1.7 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 ADV21670.1 - 5.9e-20 72.4 2.0 9.8e-10 39.1 0.9 3.2 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 ADV21670.1 - 2.9e-15 55.7 0.0 6.3e-15 54.6 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 ADV21670.1 - 1.6e-11 44.1 0.0 3.4e-11 43.1 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 ADV21670.1 - 0.00041 20.2 2.0 0.001 18.9 0.7 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase RseC_MucC PF04246.12 ADV21670.1 - 0.11 12.4 0.0 0.11 12.4 0.0 2.6 3 0 0 3 3 3 0 Positive regulator of sigma(E), RseC/MucC COX5B PF01215.19 ADV21671.1 - 5.6e-43 145.7 0.0 6.4e-43 145.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Vb Telethonin PF09470.10 ADV21671.1 - 0.022 14.7 0.1 3.6 7.4 0.0 2.1 1 1 0 2 2 2 0 Telethonin protein zf-C2H2_3 PF13878.6 ADV21671.1 - 0.078 12.8 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 zinc-finger of acetyl-transferase ESCO TFIID-18kDa PF02269.16 ADV21672.1 - 5.3e-07 29.6 0.0 1.1e-06 28.6 0.0 1.5 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit Promethin PF16015.5 ADV21673.1 - 5.7e-05 23.0 12.7 0.00018 21.4 12.7 1.7 1 1 0 1 1 1 1 Promethin Caveolin PF01146.17 ADV21673.1 - 0.034 14.1 0.4 0.052 13.5 0.4 1.2 1 0 0 1 1 1 0 Caveolin TM2 PF05154.16 ADV21673.1 - 0.044 14.1 0.8 0.044 14.1 0.8 1.7 2 0 0 2 2 2 0 TM2 domain DUF2207 PF09972.9 ADV21673.1 - 0.097 11.4 0.1 0.13 11.0 0.1 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) NAPRTase PF04095.16 ADV21674.1 - 6.2e-51 173.3 0.2 8e-51 173.0 0.2 1.1 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) family NAPRTase_N PF17767.1 ADV21674.1 - 5.3e-35 120.5 0.1 8.1e-35 119.9 0.1 1.3 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain AA_permease_2 PF13520.6 ADV21675.1 - 1.7e-59 201.8 46.3 2.1e-59 201.5 46.3 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 ADV21675.1 - 3.6e-26 91.8 40.2 5.8e-26 91.1 40.2 1.2 1 0 0 1 1 1 1 Amino acid permease DNA_pol_B_thumb PF14791.6 ADV21676.1 - 1.4e-17 63.6 0.1 2.9e-17 62.6 0.1 1.6 1 0 0 1 1 1 1 DNA polymerase beta thumb DNA_pol_B_palm PF14792.6 ADV21676.1 - 1.5e-13 50.9 0.0 3.7e-13 49.7 0.0 1.7 1 0 0 1 1 1 1 DNA polymerase beta palm HHH_8 PF14716.6 ADV21676.1 - 3.3e-11 43.4 0.0 8.6e-11 42.0 0.0 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix domain DNA_pol_lambd_f PF10391.9 ADV21676.1 - 1.8e-05 24.4 0.0 5.1e-05 23.0 0.0 1.8 1 0 0 1 1 1 1 Fingers domain of DNA polymerase lambda BRCT_2 PF16589.5 ADV21676.1 - 0.002 18.5 0.0 0.0052 17.2 0.0 1.7 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain DAO PF01266.24 ADV21677.1 - 1.7e-43 149.5 0.1 2e-43 149.3 0.1 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ADV21677.1 - 2.1e-06 27.2 0.1 0.083 12.1 0.0 3.0 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 ADV21677.1 - 0.00013 21.2 0.6 0.00044 19.5 0.6 1.8 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 ADV21677.1 - 0.00036 20.7 0.0 0.0011 19.1 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 ADV21677.1 - 0.0012 17.6 0.2 0.14 10.9 0.0 2.4 3 0 0 3 3 3 2 HI0933-like protein GIDA PF01134.22 ADV21677.1 - 0.015 14.4 0.1 0.17 10.9 0.0 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A Trp_halogenase PF04820.14 ADV21677.1 - 0.02 13.7 0.3 1.3 7.8 0.0 2.1 2 0 0 2 2 2 0 Tryptophan halogenase Pyr_redox PF00070.27 ADV21677.1 - 0.041 14.5 0.4 1 10.0 0.0 2.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 ADV21677.1 - 0.045 13.0 0.0 0.056 12.7 0.0 1.3 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase FAD_binding_3 PF01494.19 ADV21677.1 - 0.053 12.8 0.0 0.12 11.7 0.0 1.5 2 0 0 2 2 2 0 FAD binding domain NAD_binding_9 PF13454.6 ADV21677.1 - 0.11 12.5 0.3 15 5.5 0.0 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding RRM_1 PF00076.22 ADV21678.1 - 2.2e-11 43.4 0.0 6.1e-11 42.0 0.0 1.7 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) LRR_4 PF12799.7 ADV21679.1 - 9.2e-08 32.3 11.3 0.049 14.1 0.6 5.1 4 2 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 ADV21679.1 - 0.001 19.0 7.0 0.83 9.9 0.0 5.2 6 0 0 6 6 6 2 Leucine Rich repeat LRR_8 PF13855.6 ADV21679.1 - 0.25 11.1 5.3 6.5 6.6 0.2 4.5 5 0 0 5 5 5 0 Leucine rich repeat HSP70 PF00012.20 ADV21680.1 - 4.6e-261 867.3 10.0 5.2e-261 867.1 10.0 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 ADV21680.1 - 6.3e-16 58.1 3.0 1.7e-13 50.1 1.4 2.5 1 1 1 2 2 2 2 MreB/Mbl protein StbA PF06406.11 ADV21680.1 - 0.00055 19.3 0.2 0.12 11.6 0.0 2.3 1 1 1 2 2 2 2 StbA protein FGGY_C PF02782.16 ADV21680.1 - 0.035 13.8 0.0 0.082 12.6 0.0 1.6 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.6 ADV21680.1 - 0.038 14.4 11.0 0.49 10.8 0.0 3.8 3 3 0 3 3 3 0 Cell division protein FtsA Phos_pyr_kin PF08543.12 ADV21681.1 - 2.7e-11 43.3 0.0 6.5e-11 42.1 0.0 1.6 2 0 0 2 2 2 1 Phosphomethylpyrimidine kinase PfkB PF00294.24 ADV21681.1 - 3.1e-05 23.4 0.0 9.6e-05 21.8 0.0 1.7 2 0 0 2 2 2 1 pfkB family carbohydrate kinase SET PF00856.28 ADV21682.1 - 4.2e-10 40.3 0.0 8.6e-10 39.3 0.0 1.5 1 0 0 1 1 1 1 SET domain Rubis-subs-bind PF09273.11 ADV21682.1 - 1.8e-07 31.9 0.0 3.8e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding MBT PF02820.18 ADV21682.1 - 0.16 12.3 0.0 0.42 11.0 0.0 1.7 1 0 0 1 1 1 0 mbt repeat EI24 PF07264.11 ADV21683.1 - 2.3e-14 54.0 9.6 3e-14 53.7 9.6 1.1 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) SUR7 PF06687.12 ADV21685.1 - 3.7e-05 23.4 2.1 4.9e-05 23.1 2.1 1.2 1 0 0 1 1 1 1 SUR7/PalI family CcmH PF03918.14 ADV21685.1 - 0.3 10.4 1.2 0.6 9.4 0.1 1.9 2 0 0 2 2 2 0 Cytochrome C biogenesis protein Transketolase_N PF00456.21 ADV21687.1 - 2.5e-155 516.5 0.0 3.2e-155 516.2 0.0 1.1 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 ADV21687.1 - 3.7e-45 153.8 0.0 6.5e-45 153.0 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 ADV21687.1 - 2.9e-11 43.3 0.0 8.3e-11 41.8 0.0 1.9 1 1 0 1 1 1 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.6 ADV21687.1 - 1.7e-05 24.1 0.1 3e-05 23.4 0.1 1.4 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase E1_dh PF00676.20 ADV21687.1 - 0.0031 16.5 0.1 0.0046 15.9 0.1 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component Terpene_synth PF01397.21 ADV21687.1 - 0.0089 15.7 0.1 0.022 14.5 0.1 1.6 1 0 0 1 1 1 1 Terpene synthase, N-terminal domain Pyridoxal_deC PF00282.19 ADV21688.1 - 5.1e-100 334.8 0.0 6.6e-100 334.4 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain 2OG-FeII_Oxy_2 PF13532.6 ADV21689.1 - 2.9e-07 30.9 0.0 3.7e-07 30.5 0.0 1.3 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 ADV21689.1 - 0.0013 19.1 0.0 0.0043 17.5 0.0 1.8 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Mon1 PF03164.14 ADV21690.1 - 4.2e-127 424.6 0.0 5.5e-127 424.2 0.0 1.1 1 0 0 1 1 1 1 Trafficking protein Mon1 PP28 PF10252.9 ADV21691.1 - 8.6e-22 77.4 18.5 8.6e-22 77.4 18.5 3.1 1 1 1 2 2 2 1 Casein kinase substrate phosphoprotein PP28 NAD_binding_10 PF13460.6 ADV21693.1 - 1.9e-11 44.2 0.0 2.9e-11 43.6 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 ADV21693.1 - 5.3e-10 38.9 0.0 2.3e-08 33.5 0.0 2.2 1 1 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.21 ADV21693.1 - 2.1e-09 37.2 0.0 2.3e-08 33.8 0.0 2.2 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 ADV21693.1 - 4e-07 29.8 0.0 7.8e-07 28.9 0.0 1.5 1 1 0 1 1 1 1 NmrA-like family NAD_binding_4 PF07993.12 ADV21693.1 - 5e-07 29.2 0.1 0.0044 16.2 0.0 3.0 2 1 1 3 3 3 2 Male sterility protein 3Beta_HSD PF01073.19 ADV21693.1 - 1.4e-06 27.6 0.0 2.2e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short_C2 PF13561.6 ADV21693.1 - 0.099 12.2 0.0 0.18 11.4 0.0 1.4 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase RabGAP-TBC PF00566.18 ADV21694.1 - 5.1e-53 179.9 0.0 8.3e-53 179.2 0.0 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Prefoldin PF02996.17 ADV21696.1 - 1.1e-24 86.6 4.3 1.6e-21 76.4 0.4 2.4 2 1 1 3 3 3 2 Prefoldin subunit Rep_1 PF01446.17 ADV21696.1 - 0.092 12.2 1.1 0.15 11.5 1.1 1.3 1 0 0 1 1 1 0 Replication protein BHD_2 PF10404.9 ADV21696.1 - 1.8 9.5 6.1 0.88 10.6 2.2 2.4 2 1 0 2 2 2 0 Rad4 beta-hairpin domain 2 SlyX PF04102.12 ADV21696.1 - 3.4 8.3 7.7 2.6 8.7 0.1 3.6 3 1 0 3 3 3 0 SlyX FAM176 PF14851.6 ADV21696.1 - 5.8 6.6 6.7 3.1 7.4 2.3 2.2 2 0 0 2 2 2 0 FAM176 family Peptidase_C12 PF01088.21 ADV21697.1 - 1.5e-61 207.8 0.0 2e-61 207.4 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 UCH_C PF18031.1 ADV21697.1 - 5.8e-09 35.7 0.0 1.5e-08 34.4 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolases XPG_N PF00752.17 ADV21698.1 - 1.8e-32 111.8 0.0 3.3e-32 111.0 0.0 1.5 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 ADV21698.1 - 1.8e-28 98.7 0.0 1.8e-28 98.7 0.0 2.0 2 0 0 2 2 2 1 XPG I-region 5_3_exonuc PF01367.20 ADV21698.1 - 1.7e-06 28.5 0.1 4.9e-06 27.0 0.1 1.7 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold DUF3761 PF12587.8 ADV21698.1 - 0.77 10.2 3.0 0.4 11.2 0.5 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3761) HMGL-like PF00682.19 ADV21699.1 - 1.4e-77 260.8 0.3 2.4e-77 260.1 0.3 1.4 1 0 0 1 1 1 1 HMGL-like Oxidored_FMN PF00724.20 ADV21699.1 - 0.088 12.1 0.0 0.34 10.1 0.0 1.9 2 0 0 2 2 2 0 NADH:flavin oxidoreductase / NADH oxidase family FliG_N PF14842.6 ADV21699.1 - 0.11 13.0 0.1 0.24 11.9 0.1 1.4 1 0 0 1 1 1 0 FliG N-terminal domain PMT PF02366.18 ADV21700.1 - 9.6e-82 274.2 15.8 1.7e-81 273.5 15.8 1.4 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 ADV21700.1 - 1.9e-62 210.4 4.7 1.9e-62 210.4 4.7 2.9 2 1 0 3 3 3 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 ADV21700.1 - 3.7e-20 72.6 2.8 2e-19 70.2 2.2 2.0 1 1 1 2 2 2 2 MIR domain PMT_2 PF13231.6 ADV21700.1 - 1e-06 29.1 9.7 1e-06 29.1 9.7 2.3 2 2 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase Fascin PF06268.13 ADV21700.1 - 0.15 12.3 0.2 0.77 10.0 0.1 2.2 2 0 0 2 2 2 0 Fascin domain FOXP-CC PF16159.5 ADV21701.1 - 0.22 12.1 8.2 0.8 10.4 0.1 3.3 2 1 1 3 3 3 0 FOXP coiled-coil domain zf-C2H2 PF00096.26 ADV21701.1 - 0.48 11.0 11.7 1.1 9.8 2.0 3.1 3 0 0 3 3 3 0 Zinc finger, C2H2 type DUF92 PF01940.16 ADV21702.1 - 1.4e-55 188.3 0.1 1.5e-55 188.2 0.1 1.0 1 0 0 1 1 1 1 Integral membrane protein DUF92 MFS_1 PF07690.16 ADV21703.1 - 9.2e-24 84.0 31.9 6.6e-15 54.9 9.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily FAM176 PF14851.6 ADV21703.1 - 0.00017 21.3 0.0 0.00079 19.1 0.0 1.9 2 0 0 2 2 2 1 FAM176 family Nucleoside_tran PF01733.18 ADV21703.1 - 0.00035 20.1 0.1 0.00035 20.1 0.1 1.8 2 0 0 2 2 2 1 Nucleoside transporter CPP1-like PF11833.8 ADV21703.1 - 1.1 8.9 3.1 1.9 8.1 0.1 2.6 2 1 0 2 2 2 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like Glutaredoxin PF00462.24 ADV21704.1 - 9.4e-17 61.0 0.0 1.3e-16 60.5 0.0 1.2 1 0 0 1 1 1 1 Glutaredoxin GST_N_3 PF13417.6 ADV21704.1 - 4.9e-05 23.7 0.0 7.1e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain DUF836 PF05768.14 ADV21704.1 - 0.0015 18.9 0.1 0.0027 18.1 0.1 1.5 1 1 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Thioredoxin_2 PF13098.6 ADV21704.1 - 0.0016 18.9 0.0 0.0023 18.4 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like domain GST_N_2 PF13409.6 ADV21704.1 - 0.0058 16.9 0.0 0.0096 16.2 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Thioredoxin_4 PF13462.6 ADV21704.1 - 0.03 14.5 0.3 3.4 7.8 0.7 2.2 1 1 1 2 2 2 0 Thioredoxin DSBA PF01323.20 ADV21704.1 - 0.064 13.0 0.0 0.32 10.7 0.0 2.0 2 0 0 2 2 2 0 DSBA-like thioredoxin domain DUF746 PF05344.11 ADV21705.1 - 0.061 13.2 0.0 1.6 8.6 0.0 2.5 2 0 0 2 2 2 0 Domain of Unknown Function (DUF746) SLATT_1 PF18181.1 ADV21705.1 - 0.077 12.9 0.1 0.21 11.5 0.1 1.7 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 1 CRT10 PF08728.10 ADV21705.1 - 6 4.9 9.2 7.5 4.6 9.2 1.3 1 0 0 1 1 1 0 CRT10 Serinc PF03348.15 ADV21705.1 - 9 5.1 5.1 6.5 5.6 3.1 1.9 2 0 0 2 2 2 0 Serine incorporator (Serinc) C2 PF00168.30 ADV21706.1 - 3.2e-11 43.4 0.0 6.3e-11 42.5 0.0 1.5 1 0 0 1 1 1 1 C2 domain MTP18 PF10558.9 ADV21707.1 - 3.2e-62 209.5 6.2 6e-61 205.3 6.2 2.0 1 1 0 1 1 1 1 Mitochondrial 18 KDa protein (MTP18) DUF1345 PF07077.11 ADV21708.1 - 0.11 12.2 0.0 0.15 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1345) zf-C2H2 PF00096.26 ADV21709.1 - 2.1e-08 34.1 14.3 2.6e-05 24.4 1.1 3.0 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ADV21709.1 - 0.00013 22.5 12.3 0.01 16.6 0.8 3.1 3 0 0 3 3 3 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ADV21709.1 - 0.00014 22.1 9.6 0.0042 17.4 1.8 3.3 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_jaz PF12171.8 ADV21709.1 - 0.0024 18.1 2.8 0.062 13.6 0.9 2.8 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf_ZIC PF18366.1 ADV21709.1 - 0.029 14.5 1.2 2.3 8.4 0.1 2.4 2 0 0 2 2 2 0 Zic proteins zinc finger domain zf-C2H2_11 PF16622.5 ADV21709.1 - 0.46 10.3 8.1 2.2 8.1 1.1 2.7 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-C2H2_6 PF13912.6 ADV21709.1 - 0.76 9.8 6.5 1.6 8.9 0.8 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger zf-met PF12874.7 ADV21709.1 - 1.4 9.4 7.9 0.44 11.0 0.5 3.4 3 0 0 3 3 3 0 Zinc-finger of C2H2 type WD40 PF00400.32 ADV21710.1 - 6.7e-05 23.6 15.2 0.024 15.5 0.3 5.8 5 0 0 5 5 5 2 WD domain, G-beta repeat Zn_ribbon_17 PF17120.5 ADV21710.1 - 0.00017 21.2 13.7 0.00033 20.2 13.7 1.5 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type Zf_RING PF16744.5 ADV21710.1 - 0.16 12.1 4.0 0.35 11.0 4.0 1.6 1 0 0 1 1 1 0 KIAA1045 RING finger PV-1 PF06637.11 ADV21710.1 - 0.26 10.1 0.0 0.41 9.4 0.0 1.1 1 0 0 1 1 1 0 PV-1 protein (PLVAP) zf-rbx1 PF12678.7 ADV21710.1 - 1.5 9.2 16.0 3.1 8.1 16.0 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain SNF2_N PF00176.23 ADV21711.1 - 2.9e-46 157.8 0.0 5.1e-46 157.0 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain zf-C3HC4_3 PF13920.6 ADV21711.1 - 5.8e-09 35.7 4.8 9.8e-09 34.9 4.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ADV21711.1 - 1.1e-07 31.6 4.8 2.1e-07 30.7 4.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ADV21711.1 - 1.8e-06 28.1 5.5 3.7e-06 27.2 5.5 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 ADV21711.1 - 2.2e-06 27.5 5.9 4.5e-06 26.5 5.9 1.6 1 0 0 1 1 1 1 zinc-RING finger domain Helicase_C PF00271.31 ADV21711.1 - 3.4e-06 27.4 0.0 9.1e-06 26.0 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Prok-RING_4 PF14447.6 ADV21711.1 - 0.00011 22.0 4.8 0.00021 21.1 4.8 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 ADV21711.1 - 0.00016 21.8 2.2 0.00035 20.7 2.2 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 ADV21711.1 - 0.0002 21.3 4.5 0.0005 20.0 4.5 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 ADV21711.1 - 0.00051 19.8 5.0 0.0011 18.8 5.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ADV21711.1 - 0.0026 18.0 2.0 0.0064 16.8 2.0 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_4 PF14570.6 ADV21711.1 - 0.0059 16.4 6.6 0.013 15.3 6.6 1.5 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain HEPN_RnaseLS PF18869.1 ADV21711.1 - 0.049 13.8 0.0 0.14 12.3 0.0 1.7 1 0 0 1 1 1 0 RnaseLS-like HEPN zf-RING_11 PF17123.5 ADV21711.1 - 0.071 12.9 4.7 0.19 11.5 4.7 1.7 1 0 0 1 1 1 0 RING-like zinc finger FGE-sulfatase PF03781.16 ADV21711.1 - 0.083 12.4 0.5 0.65 9.5 0.1 2.5 3 0 0 3 3 3 0 Sulfatase-modifying factor enzyme 1 zf-UDP PF14569.6 ADV21711.1 - 0.091 12.9 2.1 0.23 11.6 2.1 1.6 1 0 0 1 1 1 0 Zinc-binding RING-finger HisG PF01634.18 ADV21712.1 - 7.7e-46 156.0 0.0 1.1e-45 155.5 0.0 1.2 1 0 0 1 1 1 1 ATP phosphoribosyltransferase HisG_C PF08029.11 ADV21712.1 - 8.1e-27 93.2 0.1 1.6e-26 92.2 0.1 1.5 1 0 0 1 1 1 1 HisG, C-terminal domain AroM PF07302.11 ADV21712.1 - 0.042 13.2 0.0 0.069 12.5 0.0 1.3 1 0 0 1 1 1 0 AroM protein Rad21_Rec8_N PF04825.13 ADV21714.1 - 1.1e-27 96.4 0.0 1.6e-27 95.8 0.0 1.3 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.16 ADV21714.1 - 9.8e-13 47.2 0.0 2e-12 46.2 0.0 1.5 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein TPR_2 PF07719.17 ADV21715.1 - 3.8e-07 29.7 1.2 0.054 13.6 0.1 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 ADV21715.1 - 0.0018 18.0 2.0 1.1 9.1 0.1 3.4 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 ADV21715.1 - 0.0019 18.3 1.6 0.05 13.8 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 ADV21715.1 - 0.005 17.1 0.2 0.34 11.2 0.1 2.4 2 1 0 2 2 2 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ADV21715.1 - 0.017 15.2 0.2 0.035 14.2 0.2 1.5 1 0 0 1 1 1 0 Fis1 C-terminal tetratricopeptide repeat TPR_14 PF13428.6 ADV21715.1 - 0.065 14.1 0.9 3.1 8.9 0.0 3.1 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 ADV21715.1 - 0.54 10.8 3.4 0.35 11.4 0.3 2.4 2 1 1 3 3 3 0 Tetratricopeptide repeat SH3_9 PF14604.6 ADV21716.1 - 0.00065 19.5 0.0 0.0019 18.0 0.0 1.8 1 1 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ADV21716.1 - 0.0062 16.1 0.0 0.016 14.8 0.0 1.8 1 1 0 1 1 1 1 SH3 domain ORC6 PF05460.13 ADV21716.1 - 0.19 11.0 4.1 0.28 10.4 4.1 1.2 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Sod_Cu PF00080.20 ADV21717.1 - 1.4e-48 164.7 5.1 1.6e-48 164.5 5.1 1.0 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) CHRD PF07452.12 ADV21717.1 - 0.11 13.5 1.3 0.45 11.5 1.1 1.8 1 1 1 2 2 2 0 CHRD domain eIF2_C PF09173.11 ADV21718.1 - 2.8e-30 104.4 0.2 8.6e-30 102.8 0.2 1.9 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU PF00009.27 ADV21718.1 - 1.7e-21 76.6 0.0 1.5e-20 73.6 0.0 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 ADV21718.1 - 8.1e-09 35.8 1.1 2.6e-08 34.1 0.1 2.4 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 ADV21718.1 - 0.035 14.2 0.0 0.089 12.9 0.0 1.7 2 0 0 2 2 2 0 50S ribosome-binding GTPase ProQ_C PF17516.2 ADV21718.1 - 0.1 12.0 1.0 0.26 10.7 0.4 2.0 2 0 0 2 2 2 0 ProQ C-terminal domain WD40 PF00400.32 ADV21720.1 - 5.5e-38 128.3 16.0 3.7e-07 30.7 0.0 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV21720.1 - 2.4e-19 69.4 0.0 0.00017 21.9 0.0 5.2 3 1 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ADV21720.1 - 1.5e-08 34.8 0.0 0.00018 21.5 0.0 3.0 3 0 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ADV21720.1 - 6.1e-07 28.7 0.8 0.0059 15.6 0.0 4.7 3 2 2 6 6 6 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 ADV21720.1 - 0.00014 20.8 0.0 0.33 9.7 0.0 3.2 3 0 0 3 3 3 2 Nup133 N terminal like PD40 PF07676.12 ADV21720.1 - 0.00031 20.6 0.1 4.1 7.5 0.0 3.9 3 0 0 3 3 3 2 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ADV21720.1 - 0.001 17.8 0.2 0.13 10.9 0.0 3.1 2 1 2 4 4 4 1 Nucleoporin Nup120/160 PALB2_WD40 PF16756.5 ADV21720.1 - 0.002 17.1 2.0 1.3 7.8 0.4 3.6 2 1 2 4 4 4 1 Partner and localizer of BRCA2 WD40 domain Frtz PF11768.8 ADV21720.1 - 0.007 14.7 0.0 0.019 13.3 0.0 1.6 2 0 0 2 2 2 1 WD repeat-containing and planar cell polarity effector protein Fritz WD40_like PF17005.5 ADV21720.1 - 0.045 13.1 0.0 0.17 11.2 0.0 1.9 2 0 0 2 2 2 0 WD40-like domain PQQ_2 PF13360.6 ADV21720.1 - 0.079 12.5 0.0 0.73 9.4 0.0 2.3 3 0 0 3 3 3 0 PQQ-like domain Kelch_6 PF13964.6 ADV21720.1 - 0.11 12.8 0.0 22 5.5 0.0 3.9 3 0 0 3 3 3 0 Kelch motif Lactamase_B_2 PF12706.7 ADV21723.1 - 2.7e-29 102.1 0.0 2.5e-20 72.8 0.0 2.1 2 0 0 2 2 2 2 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 ADV21723.1 - 6.6e-07 29.4 0.1 1e-05 25.5 0.1 2.2 1 1 0 1 1 1 1 Beta-lactamase superfamily domain RhoGEF PF00621.20 ADV21724.1 - 3.7e-26 92.5 0.0 5.2e-26 92.0 0.0 1.2 1 0 0 1 1 1 1 RhoGEF domain FAD_binding_1 PF00667.20 ADV21725.1 - 6.4e-54 182.9 0.0 1.7e-53 181.4 0.0 1.6 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 ADV21725.1 - 9.5e-35 119.9 0.2 2e-34 118.8 0.2 1.6 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 ADV21725.1 - 9.5e-22 77.7 0.0 3.1e-21 76.0 0.0 1.9 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Nucleoporin_N PF08801.11 ADV21727.1 - 9.2e-75 252.0 0.0 1.3e-74 251.6 0.0 1.1 1 0 0 1 1 1 1 Nup133 N terminal like Nucleoporin_C PF03177.14 ADV21727.1 - 2.8e-28 99.0 1.7 4.6e-28 98.3 1.7 1.3 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal NADH_B2 PF14813.6 ADV21728.1 - 0.0082 15.9 0.0 0.0091 15.8 0.0 1.1 1 0 0 1 1 1 1 NADH dehydrogenase 1 beta subcomplex subunit 2 Ish1 PF10281.9 ADV21729.1 - 3.3e-51 171.3 16.6 2.8e-10 40.3 0.0 7.6 7 0 0 7 7 7 5 Putative stress-responsive nuclear envelope protein HeH PF12949.7 ADV21729.1 - 6e-06 25.9 1.3 4 7.2 0.0 5.2 5 0 0 5 5 5 3 HeH/LEM domain HTH_32 PF13565.6 ADV21729.1 - 0.00041 20.9 0.4 30 5.3 0.0 4.9 3 3 1 4 4 4 0 Homeodomain-like domain LEM PF03020.15 ADV21729.1 - 0.026 14.1 0.0 11 5.7 0.0 4.2 5 0 0 5 5 5 0 LEM domain KIF1B PF12423.8 ADV21729.1 - 0.082 13.4 0.1 29 5.2 0.1 2.8 2 0 0 2 2 2 0 Kinesin protein 1B TryThrA_C PF12319.8 ADV21729.1 - 0.74 9.3 12.4 1.2 8.6 6.8 3.2 2 1 2 4 4 4 0 Tryptophan-Threonine-rich plasmodium antigen C terminal Mago_nashi PF02792.14 ADV21730.1 - 2.7e-69 231.8 0.3 3.1e-69 231.6 0.3 1.0 1 0 0 1 1 1 1 Mago nashi protein COQ7 PF03232.13 ADV21731.1 - 1.2e-68 230.3 0.1 1.4e-68 230.0 0.1 1.1 1 0 0 1 1 1 1 Ubiquinone biosynthesis protein COQ7 ATP_sub_h PF10775.9 ADV21732.1 - 1.7e-23 82.4 0.6 1.7e-23 82.4 0.6 1.5 2 0 0 2 2 2 1 ATP synthase complex subunit h Sugarporin_N PF11471.8 ADV21732.1 - 0.0098 15.8 0.0 0.02 14.8 0.0 1.5 1 0 0 1 1 1 1 Maltoporin periplasmic N-terminal extension ATP-synt_F6 PF05511.11 ADV21732.1 - 0.12 12.8 0.1 0.17 12.3 0.1 1.5 1 1 0 1 1 1 0 Mitochondrial ATP synthase coupling factor 6 HEAT_EZ PF13513.6 ADV21733.1 - 8.9e-16 58.0 6.9 2.7e-11 43.7 0.1 7.4 8 1 1 9 9 9 2 HEAT-like repeat HEAT PF02985.22 ADV21733.1 - 7.2e-11 41.4 19.5 0.016 15.4 0.0 10.8 12 1 0 12 12 12 3 HEAT repeat IBN_N PF03810.19 ADV21733.1 - 7.4e-09 35.4 4.2 9.2e-06 25.5 0.0 4.7 5 0 0 5 5 5 1 Importin-beta N-terminal domain HEAT_2 PF13646.6 ADV21733.1 - 3.1e-08 33.9 10.9 0.0028 18.0 0.3 6.3 5 1 2 7 7 7 3 HEAT repeats DUF3385 PF11865.8 ADV21733.1 - 3.5e-06 27.0 1.4 5.7 6.8 0.0 5.4 3 1 2 5 5 5 3 Domain of unknown function (DUF3385) RIX1 PF08167.12 ADV21733.1 - 3.6e-05 23.6 2.0 0.066 12.9 0.1 4.7 4 1 1 5 5 5 1 rRNA processing/ribosome biogenesis Arm PF00514.23 ADV21733.1 - 0.00013 21.9 8.8 0.48 10.5 0.0 6.4 7 0 0 7 7 7 1 Armadillo/beta-catenin-like repeat RICTOR_V PF14668.6 ADV21733.1 - 0.02 15.1 0.0 0.4 10.9 0.0 3.1 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, domain 5 FANCI_S1 PF14675.6 ADV21733.1 - 0.068 12.7 0.3 0.4 10.2 0.0 2.3 3 0 0 3 3 3 0 FANCI solenoid 1 RsbRD_N PF14361.6 ADV21733.1 - 9.9 6.9 10.0 4.2 8.1 0.3 4.0 4 0 0 4 4 4 0 RsbT co-antagonist protein rsbRD N-terminal domain ThiF PF00899.21 ADV21734.1 - 6.6e-52 176.3 0.0 9.6e-52 175.8 0.0 1.1 1 0 0 1 1 1 1 ThiF family Rhodanese PF00581.20 ADV21734.1 - 7e-11 42.6 0.0 1.7e-10 41.4 0.0 1.7 1 0 0 1 1 1 1 Rhodanese-like domain Shikimate_DH PF01488.20 ADV21734.1 - 0.0065 16.5 0.1 0.016 15.3 0.1 1.6 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase UDPG_MGDP_dh_N PF03721.14 ADV21734.1 - 0.13 11.9 0.2 0.2 11.2 0.2 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ApbA PF02558.16 ADV21734.1 - 0.13 11.9 0.5 2.4 7.8 0.3 2.2 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA adh_short_C2 PF13561.6 ADV21735.1 - 6e-51 173.2 0.0 7.4e-51 173.0 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ADV21735.1 - 1e-37 129.5 0.0 1.3e-37 129.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ADV21735.1 - 2.2e-07 31.0 0.0 3.1e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 KR domain RRM_1 PF00076.22 ADV21736.1 - 0.044 13.6 0.0 0.11 12.4 0.0 1.7 1 1 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ctr PF04145.15 ADV21738.1 - 5.1e-29 101.8 0.2 6.7e-29 101.4 0.2 1.1 1 0 0 1 1 1 1 Ctr copper transporter family VHS PF00790.19 ADV21739.1 - 2.4e-35 121.4 0.0 5.3e-35 120.3 0.0 1.6 1 0 0 1 1 1 1 VHS domain GAT PF03127.14 ADV21739.1 - 8.7e-17 61.2 0.0 6.1e-16 58.5 0.0 2.5 2 0 0 2 2 2 1 GAT domain GGA_N-GAT PF18308.1 ADV21739.1 - 0.01 15.4 0.4 0.032 13.8 0.2 2.0 2 0 0 2 2 2 0 GGA N-GAT domain CPSase_sm_chain PF00988.22 ADV21740.1 - 1.1e-44 151.4 0.0 1.9e-44 150.6 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.28 ADV21740.1 - 2.7e-37 128.4 0.0 3.7e-37 128.0 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 ADV21740.1 - 1.2e-07 31.7 0.1 3.5e-06 26.9 0.1 2.5 1 1 0 1 1 1 1 Peptidase C26 DJ-1_PfpI PF01965.24 ADV21740.1 - 0.0053 16.6 0.0 0.0095 15.7 0.0 1.4 1 0 0 1 1 1 1 DJ-1/PfpI family Acetyltransf_10 PF13673.7 ADV21741.1 - 6.2e-15 55.3 0.0 2.2e-12 47.0 0.0 2.5 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ADV21741.1 - 2.5e-09 37.4 0.0 3.2e-09 37.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ADV21741.1 - 4.5e-06 26.9 0.0 0.00024 21.3 0.0 2.2 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_5 PF13444.6 ADV21741.1 - 0.00037 21.2 0.0 0.003 18.2 0.0 2.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ADV21741.1 - 0.0036 17.2 0.0 0.24 11.4 0.0 2.2 1 1 0 1 1 1 1 FR47-like protein CTP_transf_1 PF01148.20 ADV21742.1 - 1.3e-75 254.6 16.7 1.8e-75 254.1 16.7 1.2 1 0 0 1 1 1 1 Cytidylyltransferase family QslA_E PF18226.1 ADV21743.1 - 0.14 12.1 0.0 0.24 11.3 0.0 1.3 1 0 0 1 1 1 0 LasR-specific antiactivator QslA chain E OB_NTP_bind PF07717.16 ADV21745.1 - 4e-22 78.4 0.0 8.7e-22 77.3 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 ADV21745.1 - 1.3e-21 76.9 0.0 4.7e-21 75.1 0.0 2.0 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 ADV21745.1 - 1.1e-12 48.3 0.0 2.9e-12 46.9 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain S1 PF00575.23 ADV21745.1 - 5.8e-07 29.8 0.7 6.7e-06 26.4 0.7 2.4 1 1 0 1 1 1 1 S1 RNA binding domain AAA_22 PF13401.6 ADV21745.1 - 0.00011 22.5 0.1 0.0012 19.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain DEAD PF00270.29 ADV21745.1 - 0.00014 21.7 0.1 0.00039 20.2 0.1 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_30 PF13604.6 ADV21745.1 - 0.00023 21.0 0.0 0.00068 19.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 ADV21745.1 - 0.0021 17.2 0.0 0.008 15.3 0.0 1.9 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_19 PF13245.6 ADV21745.1 - 0.0023 18.3 0.1 0.035 14.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain DUF2075 PF09848.9 ADV21745.1 - 0.026 13.8 0.0 0.055 12.7 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_14 PF13173.6 ADV21745.1 - 0.052 13.6 0.0 0.42 10.7 0.0 2.4 2 1 0 2 2 2 0 AAA domain PhoH PF02562.16 ADV21745.1 - 0.063 12.7 0.0 0.16 11.4 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein IF3_C PF00707.22 ADV21745.1 - 0.14 12.2 0.1 0.5 10.4 0.1 1.9 1 0 0 1 1 1 0 Translation initiation factor IF-3, C-terminal domain MutS_V PF00488.21 ADV21747.1 - 4.2e-55 186.7 1.5 1.1e-54 185.3 0.5 2.1 2 0 0 2 2 2 1 MutS domain V MutS_III PF05192.18 ADV21747.1 - 4e-27 95.7 3.7 4e-27 95.7 3.7 1.9 2 0 0 2 2 2 1 MutS domain III MutS_IV PF05190.18 ADV21747.1 - 2.1e-11 44.0 0.0 7.9e-11 42.2 0.0 2.1 1 0 0 1 1 1 1 MutS family domain IV MutS_II PF05188.17 ADV21747.1 - 1.9e-05 24.9 0.0 8.9e-05 22.8 0.0 2.2 1 1 0 1 1 1 1 MutS domain II ATPase_2 PF01637.18 ADV21747.1 - 0.0077 16.2 0.7 0.92 9.4 0.0 2.4 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea AAA_27 PF13514.6 ADV21747.1 - 0.051 13.2 0.1 0.46 10.1 0.0 2.5 3 0 0 3 3 3 0 AAA domain DUF1717 PF05414.11 ADV21747.1 - 0.062 13.7 0.0 0.81 10.2 0.0 2.5 2 0 0 2 2 2 0 Viral domain of unknown function (DUF1717) CHCH PF06747.13 ADV21748.1 - 1.8e-07 31.1 5.2 1.8e-07 31.1 5.2 2.3 2 1 0 2 2 2 1 CHCH domain CX9C PF16860.5 ADV21748.1 - 4.5e-05 23.4 13.5 0.0038 17.2 4.7 2.2 2 0 0 2 2 2 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Cmc1 PF08583.10 ADV21748.1 - 0.24 11.5 13.5 0.21 11.6 4.1 2.4 1 1 1 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like Pet191_N PF10203.9 ADV21748.1 - 0.61 10.4 12.8 4.8 7.6 0.3 2.9 1 1 2 3 3 3 0 Cytochrome c oxidase assembly protein PET191 COX6B PF02297.17 ADV21748.1 - 0.77 10.0 13.2 0.26 11.6 4.6 2.2 1 1 1 2 2 2 0 Cytochrome oxidase c subunit VIb GCK PF07802.11 ADV21748.1 - 1.4 9.3 7.8 26 5.3 7.8 2.2 1 1 0 1 1 1 0 GCK domain Ufd2P_core PF10408.9 ADV21749.1 - 2.5e-196 654.1 0.0 3e-196 653.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin elongating factor core U-box PF04564.15 ADV21749.1 - 1.4e-24 86.1 0.1 4e-24 84.6 0.1 1.9 1 0 0 1 1 1 1 U-box domain Sec2p PF06428.11 ADV21749.1 - 0.013 15.5 0.5 0.68 9.9 0.2 2.5 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p UPF0029 PF01205.19 ADV21750.1 - 7.5e-31 106.6 0.0 1.1e-30 106.0 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 RWD PF05773.22 ADV21750.1 - 3.3e-05 24.1 0.0 0.00026 21.2 0.0 2.3 2 1 0 2 2 2 1 RWD domain DUF4646 PF15496.6 ADV21752.1 - 1.1e-09 38.9 0.4 1.4e-08 35.4 0.2 2.1 1 1 0 2 2 2 1 Domain of unknown function (DUF4646) Proteasome PF00227.26 ADV21753.1 - 2.5e-59 200.0 0.0 3.6e-59 199.5 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 ADV21753.1 - 3.7e-14 52.1 0.1 1.2e-13 50.4 0.1 1.9 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature HATPase_c_3 PF13589.6 ADV21754.1 - 1.1e-12 48.0 0.1 5e-12 45.8 0.0 2.0 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 ADV21754.1 - 5.7e-09 36.5 0.0 1.4e-08 35.2 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MutL_C PF08676.11 ADV21754.1 - 9.2e-05 22.3 0.1 0.00057 19.7 0.0 2.4 3 0 0 3 3 3 1 MutL C terminal dimerisation domain DNA_mis_repair PF01119.19 ADV21754.1 - 0.0049 16.5 0.0 0.0092 15.7 0.0 1.4 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain TPR_2 PF07719.17 ADV21755.1 - 1.1e-37 125.1 29.3 8.1e-05 22.4 0.1 15.8 16 0 0 16 16 15 8 Tetratricopeptide repeat TPR_1 PF00515.28 ADV21755.1 - 1.5e-37 125.8 14.4 6.7e-08 32.0 0.1 13.3 14 0 0 14 14 13 8 Tetratricopeptide repeat TPR_8 PF13181.6 ADV21755.1 - 6e-29 97.8 14.8 1.6e-06 27.9 0.1 13.9 16 0 0 16 16 15 5 Tetratricopeptide repeat TPR_16 PF13432.6 ADV21755.1 - 3.8e-28 97.9 31.9 5.5e-08 33.3 0.0 13.2 10 4 2 13 13 13 5 Tetratricopeptide repeat TPR_19 PF14559.6 ADV21755.1 - 1.6e-21 76.6 24.8 0.00021 21.7 0.1 10.6 10 1 1 11 11 11 4 Tetratricopeptide repeat TPR_17 PF13431.6 ADV21755.1 - 3.3e-21 74.1 16.3 0.063 13.7 0.0 13.5 14 0 0 14 14 14 5 Tetratricopeptide repeat TPR_12 PF13424.6 ADV21755.1 - 5.8e-21 74.6 38.5 7.2e-07 29.4 0.0 13.5 13 1 1 14 14 14 6 Tetratricopeptide repeat TPR_14 PF13428.6 ADV21755.1 - 6.7e-18 63.9 46.9 0.0043 17.7 0.2 16.6 15 4 5 20 20 18 5 Tetratricopeptide repeat TPR_11 PF13414.6 ADV21755.1 - 8.7e-15 54.1 17.1 0.004 16.8 0.2 9.9 7 2 3 10 10 10 4 TPR repeat ANAPC3 PF12895.7 ADV21755.1 - 3.1e-11 43.4 16.2 0.078 13.2 0.2 8.8 7 2 2 9 9 9 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 ADV21755.1 - 8.6e-10 38.6 24.9 6.1e-05 23.1 0.0 9.6 11 2 2 13 13 12 2 Tetratricopeptide repeat TPR_6 PF13174.6 ADV21755.1 - 6.6e-09 35.8 23.2 0.027 15.1 0.2 11.9 15 0 0 15 15 12 2 Tetratricopeptide repeat TPR_7 PF13176.6 ADV21755.1 - 5.2e-06 26.1 29.7 6.8e-05 22.6 0.0 10.9 12 0 0 12 12 11 1 Tetratricopeptide repeat TPR_20 PF14561.6 ADV21755.1 - 0.00023 21.5 11.7 0.07 13.5 0.1 6.0 6 1 0 6 6 5 2 Tetratricopeptide repeat TPR_MalT PF17874.1 ADV21755.1 - 0.00035 20.1 12.4 1.5 8.1 0.6 5.8 4 2 1 5 5 5 1 MalT-like TPR region NatB_MDM20 PF09797.9 ADV21755.1 - 0.0013 17.8 0.0 0.0046 16.0 0.0 2.0 1 0 0 1 1 1 1 N-acetyltransferase B complex (NatB) non catalytic subunit TPR_10 PF13374.6 ADV21755.1 - 0.0013 18.6 13.0 0.1 12.5 0.2 7.1 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_5 PF12688.7 ADV21755.1 - 0.017 15.4 0.1 0.017 15.4 0.1 5.3 7 0 0 7 7 4 0 Tetratrico peptide repeat HrpB1_HrpK PF09613.10 ADV21755.1 - 0.052 13.2 0.8 1.5 8.5 0.0 3.8 3 1 0 3 3 3 0 Bacterial type III secretion protein (HrpB1_HrpK) ANAPC5 PF12862.7 ADV21755.1 - 0.15 12.1 0.7 13 5.9 0.0 3.8 3 1 1 4 4 4 0 Anaphase-promoting complex subunit 5 NARP1 PF12569.8 ADV21755.1 - 0.22 10.4 9.4 6.5 5.5 0.1 5.2 6 0 0 6 6 6 0 NMDA receptor-regulated protein 1 BTAD PF03704.17 ADV21755.1 - 7.8 6.9 17.5 3.5 8.0 0.1 5.7 4 1 1 5 5 5 0 Bacterial transcriptional activator domain MARVEL PF01284.23 ADV21756.1 - 7e-13 48.8 20.4 9.9e-13 48.3 20.4 1.2 1 0 0 1 1 1 1 Membrane-associating domain TMEM173 PF15009.6 ADV21756.1 - 0.68 9.0 2.0 0.81 8.8 2.0 1.1 1 0 0 1 1 1 0 Transmembrane protein 173 Ceramidase PF05875.12 ADV21757.1 - 4.2e-76 255.8 1.6 5.2e-76 255.5 1.6 1.0 1 0 0 1 1 1 1 Ceramidase Ndc1_Nup PF09531.10 ADV21758.1 - 1.1e-63 215.9 8.5 1.3e-63 215.7 8.5 1.0 1 0 0 1 1 1 1 Nucleoporin protein Ndc1-Nup DAO PF01266.24 ADV21759.1 - 6.9e-35 121.3 0.9 8e-35 121.1 0.9 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ADV21759.1 - 0.00038 19.8 0.0 0.078 12.2 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 ADV21759.1 - 0.0006 19.0 0.7 0.32 10.0 0.0 2.3 2 0 0 2 2 2 2 Lycopene cyclase protein NAD_binding_8 PF13450.6 ADV21759.1 - 0.0034 17.6 0.1 0.0088 16.3 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 ADV21759.1 - 0.0072 16.3 1.6 0.34 10.9 0.0 2.3 2 0 0 2 2 2 1 FAD-NAD(P)-binding HI0933_like PF03486.14 ADV21759.1 - 0.0074 15.0 0.1 0.059 12.1 0.0 1.9 2 0 0 2 2 2 1 HI0933-like protein ApbA PF02558.16 ADV21759.1 - 0.013 15.2 0.1 0.027 14.1 0.1 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA TrkA_N PF02254.18 ADV21759.1 - 0.013 15.7 0.1 0.03 14.6 0.1 1.6 1 0 0 1 1 1 0 TrkA-N domain AlaDh_PNT_C PF01262.21 ADV21759.1 - 0.024 13.9 0.0 0.044 13.1 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Sacchrp_dh_NADP PF03435.18 ADV21759.1 - 0.03 14.6 0.2 0.07 13.4 0.2 1.6 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Pyr_redox PF00070.27 ADV21759.1 - 0.07 13.7 0.8 0.15 12.6 0.2 1.9 2 0 0 2 2 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ADV21759.1 - 0.084 12.1 0.2 0.24 10.6 0.0 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 ADV21759.1 - 0.089 12.0 0.2 0.18 11.0 0.2 1.5 1 0 0 1 1 1 0 FAD binding domain 3HCDH_N PF02737.18 ADV21759.1 - 0.096 12.6 0.1 0.16 11.9 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 ADV21759.1 - 0.13 11.7 0.0 0.23 10.8 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 ADV21759.1 - 0.13 11.8 0.1 0.2 11.2 0.1 1.2 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ThiF PF00899.21 ADV21759.1 - 0.14 11.5 0.0 0.23 10.8 0.0 1.2 1 0 0 1 1 1 0 ThiF family Shikimate_DH PF01488.20 ADV21759.1 - 0.16 12.0 0.0 0.29 11.2 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Trp_halogenase PF04820.14 ADV21759.1 - 0.17 10.7 0.0 0.96 8.2 0.0 1.9 2 0 0 2 2 2 0 Tryptophan halogenase Nop10p PF04135.12 ADV21760.1 - 1e-22 79.9 0.4 1.2e-22 79.7 0.4 1.1 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family Dynactin PF12455.8 ADV21761.1 - 2.6e-80 269.7 0.1 2.6e-80 269.7 0.1 3.7 3 1 1 4 4 4 1 Dynein associated protein CAP_GLY PF01302.25 ADV21761.1 - 4.8e-21 74.5 1.2 1.2e-20 73.2 1.2 1.7 1 0 0 1 1 1 1 CAP-Gly domain COMM_domain PF07258.14 ADV21761.1 - 0.29 11.3 3.2 7.5 6.7 0.4 3.5 2 0 0 2 2 2 0 COMM domain NBD94 PF16830.5 ADV21761.1 - 5.3 7.5 12.4 3.2 8.2 6.0 3.3 2 0 0 2 2 2 0 Nucleotide-Binding Domain 94 of RH DUF885 PF05960.11 ADV21762.1 - 0.0028 17.4 1.6 0.0046 16.7 1.6 1.3 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF885) Apolipoprotein PF01442.18 ADV21762.1 - 0.0073 16.2 10.8 0.27 11.1 6.9 2.4 1 1 1 2 2 2 2 Apolipoprotein A1/A4/E domain DUF883 PF05957.13 ADV21762.1 - 0.0092 16.6 11.3 1.1 9.9 0.2 3.8 2 1 1 3 3 3 1 Bacterial protein of unknown function (DUF883) CSTF2_hinge PF14327.6 ADV21762.1 - 0.01 16.3 0.3 9 6.8 0.1 3.0 3 0 0 3 3 3 0 Hinge domain of cleavage stimulation factor subunit 2 DUF4366 PF14283.6 ADV21762.1 - 0.036 14.1 5.1 0.4 10.7 0.0 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4366) Phasin PF05597.11 ADV21762.1 - 0.047 13.7 13.0 0.36 10.9 3.4 3.3 2 1 1 3 3 3 0 Poly(hydroxyalcanoate) granule associated protein (phasin) Gp-FAR-1 PF05823.12 ADV21762.1 - 0.085 13.2 10.9 0.034 14.5 3.4 2.5 1 1 1 2 2 2 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) DUF3231 PF11553.8 ADV21762.1 - 0.13 11.9 0.7 0.91 9.1 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3231) Ribosomal_S6 PF01250.17 ADV21762.1 - 0.17 12.2 0.3 0.74 10.1 0.1 2.2 2 0 0 2 2 1 0 Ribosomal protein S6 AIF-MLS PF14962.6 ADV21762.1 - 0.18 11.7 0.1 0.18 11.7 0.1 2.1 2 0 0 2 2 2 0 Mitochondria Localisation Sequence DUF4375 PF14300.6 ADV21762.1 - 0.21 11.9 1.8 9.1 6.6 0.0 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4375) KfrA_N PF11740.8 ADV21762.1 - 0.44 11.2 6.6 1.8 9.3 0.6 3.2 2 1 1 3 3 3 0 Plasmid replication region DNA-binding N-term FAM184 PF15665.5 ADV21762.1 - 0.49 10.2 10.3 1.1 8.9 0.8 2.2 1 1 1 2 2 2 0 Family with sequence similarity 184, A and B TipAS PF07739.13 ADV21762.1 - 0.52 10.9 7.4 20 5.8 0.0 3.1 2 1 0 2 2 2 0 TipAS antibiotic-recognition domain Spore_III_AB PF09548.10 ADV21762.1 - 0.67 10.1 3.2 6.2 6.9 3.0 2.3 1 1 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) V-SNARE PF05008.15 ADV21762.1 - 0.71 10.3 6.3 1.4 9.4 0.2 3.1 2 1 1 3 3 3 0 Vesicle transport v-SNARE protein N-terminus Med8 PF10232.9 ADV21762.1 - 0.95 9.0 5.0 0.34 10.5 1.9 1.7 1 1 1 2 2 2 0 Mediator of RNA polymerase II transcription complex subunit 8 DUF2913 PF11140.8 ADV21762.1 - 1.5 8.5 5.7 0.7 9.6 1.8 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF2913) DUF4854 PF16146.5 ADV21762.1 - 1.7 9.0 4.5 16 5.9 0.8 3.4 1 1 2 3 3 3 0 Domain of unknown function (DUF4854) DUF4358 PF14270.6 ADV21762.1 - 2.1 8.7 5.8 0.73 10.2 0.5 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4358) Ssu72 PF04722.13 ADV21763.1 - 2.2e-70 236.2 0.0 2.6e-70 235.9 0.0 1.0 1 0 0 1 1 1 1 Ssu72-like protein zf-NOSIP PF15906.5 ADV21764.1 - 3.8e-05 23.7 4.3 9.3e-05 22.5 0.6 2.5 2 0 0 2 2 2 1 Zinc-finger of nitric oxide synthase-interacting protein zf-RING_UBOX PF13445.6 ADV21764.1 - 4.3e-05 23.4 15.0 0.003 17.6 1.9 2.8 2 1 0 2 2 2 2 RING-type zinc-finger zf-C3HC4_3 PF13920.6 ADV21764.1 - 6.4e-05 22.7 20.3 0.00041 20.1 2.7 3.2 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ADV21764.1 - 0.00016 21.5 21.4 0.00053 19.8 1.7 3.3 3 0 0 3 3 3 2 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 ADV21764.1 - 0.00049 20.4 19.7 0.0012 19.1 2.5 3.2 3 0 0 3 3 3 2 Ring finger domain zf-RING_5 PF14634.6 ADV21764.1 - 0.0026 17.7 3.2 0.0026 17.7 3.2 3.5 3 1 0 3 3 3 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 ADV21764.1 - 0.0038 17.0 18.2 0.027 14.3 2.3 3.2 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ADV21764.1 - 0.014 15.3 20.9 0.12 12.3 7.3 3.1 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) TfuA PF07812.12 ADV21764.1 - 0.13 12.0 0.2 0.23 11.2 0.2 1.4 1 0 0 1 1 1 0 TfuA-like protein zf-C3HC4_4 PF15227.6 ADV21764.1 - 0.21 11.8 21.2 0.79 9.9 6.1 3.0 3 0 0 3 3 3 0 zinc finger of C3HC4-type, RING zinc-ribbons_6 PF07191.12 ADV21764.1 - 1.2 9.2 17.1 7.2 6.7 2.3 3.2 2 1 1 3 3 3 0 zinc-ribbons zf-RING_10 PF16685.5 ADV21764.1 - 3 8.0 14.8 0.22 11.7 1.6 3.0 3 0 0 3 3 3 0 zinc RING finger of MSL2 RRM_1 PF00076.22 ADV21765.1 - 5.8e-19 67.7 0.0 7.9e-19 67.2 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ADV21765.1 - 4.8e-06 26.2 0.0 6.4e-06 25.8 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 ADV21765.1 - 0.016 15.2 0.0 0.025 14.6 0.0 1.3 1 0 0 1 1 1 0 RNA binding motif HLH PF00010.26 ADV21767.1 - 2.4e-06 27.4 2.9 6.4e-06 26.0 2.9 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF641 PF04859.12 ADV21767.1 - 0.72 10.2 4.2 1.2 9.5 4.2 1.3 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) Pterin_4a PF01329.19 ADV21768.1 - 1.5e-06 28.3 0.0 2.5e-05 24.3 0.0 2.3 1 1 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase Aminotran_3 PF00202.21 ADV21769.1 - 1.2e-104 350.2 0.0 1.4e-104 350.0 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aldedh PF00171.22 ADV21770.1 - 1.2e-178 594.4 0.1 1.4e-178 594.2 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family FMN_dh PF01070.18 ADV21771.1 - 3.6e-126 420.9 0.4 4.1e-126 420.7 0.4 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.25 ADV21771.1 - 1.9e-07 30.4 0.6 2.3e-05 23.6 0.2 2.4 1 1 1 2 2 2 2 IMP dehydrogenase / GMP reductase domain ThiG PF05690.14 ADV21771.1 - 7e-05 22.3 0.8 0.018 14.4 0.1 3.1 2 1 1 3 3 3 2 Thiazole biosynthesis protein ThiG NMO PF03060.15 ADV21771.1 - 0.0001 21.8 0.8 0.00015 21.2 0.8 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase His_biosynth PF00977.21 ADV21771.1 - 0.00022 20.8 0.4 0.0035 16.8 0.0 2.5 2 1 1 3 3 3 1 Histidine biosynthesis protein Glu_synthase PF01645.17 ADV21771.1 - 0.00079 18.7 0.2 0.0019 17.4 0.1 1.6 2 0 0 2 2 2 1 Conserved region in glutamate synthase Epimerase PF01370.21 ADV21772.1 - 0.0043 16.5 0.0 0.026 14.0 0.0 1.9 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 ADV21772.1 - 0.03 13.9 0.0 0.05 13.2 0.0 1.4 1 0 0 1 1 1 0 NmrA-like family NAD_binding_10 PF13460.6 ADV21772.1 - 0.036 14.0 0.0 0.08 12.8 0.0 1.6 1 0 0 1 1 1 0 NAD(P)H-binding adh_short PF00106.25 ADV21772.1 - 0.14 11.6 0.0 0.24 10.8 0.0 1.4 1 0 0 1 1 1 0 short chain dehydrogenase Ank_4 PF13637.6 ADV21773.1 - 1.6e-18 66.8 1.7 3.2e-08 33.9 0.1 3.6 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ADV21773.1 - 4.4e-15 54.3 0.4 5.2e-05 23.3 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeat Ank_2 PF12796.7 ADV21773.1 - 1.3e-14 54.6 0.1 7.8e-06 26.4 0.0 2.5 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 ADV21773.1 - 5.8e-14 51.8 4.2 3.2e-06 27.3 0.1 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 ADV21773.1 - 2.5e-13 50.0 0.6 4.7e-05 23.6 0.0 3.0 2 1 1 3 3 3 2 Ankyrin repeats (many copies) EAF PF09816.9 ADV21774.1 - 3.8e-14 52.9 0.0 8.3e-14 51.8 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase II transcription elongation factor DNA_pol_phi PF04931.13 ADV21774.1 - 5.5 5.0 20.3 8.3 4.4 20.3 1.2 1 0 0 1 1 1 0 DNA polymerase phi Neisseria_TspB PF05616.13 ADV21776.1 - 7.2 5.0 6.8 9.4 4.6 6.8 1.1 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein Rick_17kDa_Anti PF05433.15 ADV21777.1 - 0.14 12.0 6.7 2.3 8.2 1.9 2.2 2 0 0 2 2 2 0 Glycine zipper 2TM domain Tim17 PF02466.19 ADV21777.1 - 0.64 10.4 6.3 8.7 6.8 6.3 2.2 1 1 0 1 1 1 0 Tim17/Tim22/Tim23/Pmp24 family Gly-zipper_YMGG PF13441.6 ADV21777.1 - 0.87 9.4 6.5 4.6 7.1 0.8 2.2 2 0 0 2 2 2 0 YMGG-like Gly-zipper Sec7 PF01369.20 ADV21778.1 - 7.9e-28 97.4 0.1 1.2e-27 96.8 0.1 1.2 1 0 0 1 1 1 1 Sec7 domain DUF4148 PF13663.6 ADV21778.1 - 0.018 15.2 0.1 0.071 13.3 0.1 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4148) Cnn_1N PF07989.11 ADV21779.1 - 2e-17 63.1 12.9 2e-17 63.1 12.9 13.4 7 2 5 13 13 13 3 Centrosomin N-terminal motif 1 Tropomyosin PF00261.20 ADV21779.1 - 6.4e-05 22.4 14.8 6.4e-05 22.4 14.8 8.8 1 1 5 8 8 8 3 Tropomyosin DASH_Dad4 PF08650.10 ADV21779.1 - 0.12 12.4 5.4 5.2 7.1 0.1 5.0 4 0 0 4 4 4 0 DASH complex subunit Dad4 BRI3BP PF14965.6 ADV21779.1 - 0.99 8.9 4.8 1.5 8.3 0.9 3.1 2 0 0 2 2 2 0 Negative regulator of p53/TP53 adh_short_C2 PF13561.6 ADV21780.1 - 3.8e-54 183.7 0.2 4.8e-54 183.4 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ADV21780.1 - 1.7e-50 171.2 0.4 2e-50 171.0 0.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ADV21780.1 - 7.7e-11 42.2 1.6 1.1e-10 41.8 1.6 1.1 1 0 0 1 1 1 1 KR domain THF_DHG_CYH_C PF02882.19 ADV21780.1 - 0.016 14.5 0.0 0.028 13.8 0.0 1.5 1 1 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Epimerase PF01370.21 ADV21780.1 - 0.017 14.6 0.0 0.025 14.0 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Glyco_tran_WecB PF03808.13 ADV21780.1 - 0.027 14.4 0.1 0.048 13.6 0.1 1.3 1 0 0 1 1 1 0 Glycosyl transferase WecB/TagA/CpsF family OTCace PF00185.24 ADV21780.1 - 0.035 14.2 0.2 0.053 13.6 0.2 1.4 1 0 0 1 1 1 0 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain Glyco_trans_4_4 PF13579.6 ADV21780.1 - 0.043 14.3 0.6 3 8.2 0.1 2.2 2 0 0 2 2 2 0 Glycosyl transferase 4-like domain NAD_binding_7 PF13241.6 ADV21780.1 - 0.049 14.1 0.3 0.094 13.2 0.3 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding 3HCDH_N PF02737.18 ADV21780.1 - 0.054 13.4 0.6 0.099 12.5 0.3 1.6 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF1776 PF08643.10 ADV21780.1 - 0.09 12.1 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) GDP_Man_Dehyd PF16363.5 ADV21780.1 - 0.13 11.7 0.2 0.16 11.3 0.2 1.1 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Methyltransf_8 PF05148.15 ADV21781.1 - 3.7e-52 177.4 0.0 3.2e-26 92.5 0.0 2.3 2 0 0 2 2 2 2 Hypothetical methyltransferase Methyltransf_11 PF08241.12 ADV21781.1 - 0.022 15.4 0.0 8.4 7.1 0.0 2.6 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_25 PF13649.6 ADV21781.1 - 0.19 12.4 0.9 20 6.0 0.1 3.0 4 0 0 4 4 4 0 Methyltransferase domain PIGA PF08288.12 ADV21782.1 - 6e-37 126.1 0.1 1.3e-36 125.1 0.1 1.6 1 0 0 1 1 1 1 PIGA (GPI anchor biosynthesis) Acyltransferase PF01553.21 ADV21782.1 - 6.5e-33 113.2 0.0 1.3e-32 112.3 0.0 1.5 1 0 0 1 1 1 1 Acyltransferase Glyco_transf_4 PF13439.6 ADV21782.1 - 3.1e-27 95.7 0.4 6.3e-27 94.6 0.4 1.6 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glycos_transf_1 PF00534.20 ADV21782.1 - 5.4e-26 91.2 0.0 1e-25 90.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ADV21782.1 - 7.4e-21 75.0 0.1 2.4e-20 73.3 0.1 1.8 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 ADV21782.1 - 2.3e-12 47.7 0.1 9.4e-12 45.7 0.0 2.1 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_trans_4_2 PF13477.6 ADV21782.1 - 0.0011 19.1 0.0 0.0022 18.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase 4-like Glyco_trans_1_2 PF13524.6 ADV21782.1 - 0.002 18.5 0.0 0.0044 17.4 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Prok-JAB PF14464.6 ADV21782.1 - 0.056 13.2 0.1 0.14 11.9 0.1 1.7 1 0 0 1 1 1 0 Prokaryotic homologs of the JAB domain GPI-anchored PF10342.9 ADV21783.1 - 0.0028 18.4 0.2 0.0088 16.8 0.0 1.9 2 1 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family CSN8_PSD8_EIF3K PF10075.9 ADV21784.1 - 8.8e-14 51.7 0.0 1.6e-13 50.9 0.0 1.4 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family Apt1 PF10351.9 ADV21785.1 - 3.7e-84 283.3 0.0 8.8e-84 282.1 0.0 1.7 1 0 0 1 1 1 1 Golgi-body localisation protein domain Fmp27_WPPW PF10359.9 ADV21785.1 - 1.5e-43 149.4 1.8 8.9e-43 146.8 1.8 2.1 1 1 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain Fmp27_GFWDK PF10347.9 ADV21785.1 - 5.7e-42 143.5 0.1 1.3e-41 142.3 0.1 1.7 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain DUF2405 PF10293.9 ADV21785.1 - 1.4e-30 106.3 0.0 3.1e-30 105.2 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF2405) Fmp27_SW PF10305.9 ADV21785.1 - 8.7e-12 45.7 0.0 3.1e-11 43.9 0.0 2.1 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain ABC_tran PF00005.27 ADV21786.1 - 2.6e-44 151.1 0.0 7.6e-22 78.3 0.0 3.9 2 2 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 ADV21786.1 - 8.1e-17 62.0 7.5 1.2e-06 28.6 0.5 4.3 2 2 0 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ADV21786.1 - 3e-13 49.7 1.7 0.033 13.6 0.0 4.3 4 0 0 4 4 4 4 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ADV21786.1 - 8.7e-10 38.2 0.3 0.0023 17.7 0.0 3.1 3 0 0 3 3 3 2 P-loop containing region of AAA domain AAA_23 PF13476.6 ADV21786.1 - 6.3e-08 33.4 0.8 0.014 15.9 0.0 3.0 2 1 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 ADV21786.1 - 1e-06 28.8 0.0 0.026 14.6 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ADV21786.1 - 3e-06 27.3 0.0 0.11 12.4 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase DUF87 PF01935.17 ADV21786.1 - 4.3e-06 27.0 0.1 0.0084 16.2 0.0 3.1 3 0 0 3 3 3 1 Helicase HerA, central domain HEAT PF02985.22 ADV21786.1 - 1.2e-05 25.1 3.2 0.55 10.6 0.1 5.1 4 0 0 4 4 4 1 HEAT repeat AAA_15 PF13175.6 ADV21786.1 - 2.7e-05 24.0 1.8 0.091 12.4 0.0 3.4 3 1 1 4 4 4 2 AAA ATPase domain CLASP_N PF12348.8 ADV21786.1 - 0.00012 21.7 0.1 0.00041 20.0 0.0 1.9 1 1 0 1 1 1 1 CLASP N terminal AAA_22 PF13401.6 ADV21786.1 - 0.00013 22.2 0.0 0.69 10.2 0.0 2.8 2 0 0 2 2 2 2 AAA domain MeaB PF03308.16 ADV21786.1 - 0.00013 21.0 0.0 0.058 12.4 0.0 2.7 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB 4HB PF17947.1 ADV21786.1 - 0.00017 21.6 0.0 0.00056 19.9 0.0 1.9 1 0 0 1 1 1 1 Four helical bundle domain NACHT PF05729.12 ADV21786.1 - 0.00025 21.0 0.4 1.2 9.0 0.0 3.0 3 0 0 3 3 2 2 NACHT domain AAA_28 PF13521.6 ADV21786.1 - 0.00035 20.9 0.0 0.083 13.1 0.0 2.8 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 ADV21786.1 - 0.00037 20.9 0.0 1.4 9.4 0.0 2.8 2 0 0 2 2 2 2 RNA helicase AAA_18 PF13238.6 ADV21786.1 - 0.00046 20.7 0.0 0.1 13.2 0.0 2.9 3 0 0 3 3 2 1 AAA domain AAA_16 PF13191.6 ADV21786.1 - 0.00068 20.1 0.1 0.12 12.7 0.0 3.2 3 0 0 3 3 2 1 AAA ATPase domain ATPase_2 PF01637.18 ADV21786.1 - 0.001 19.0 0.0 0.92 9.4 0.0 3.3 3 0 0 3 3 3 1 ATPase domain predominantly from Archaea SbcCD_C PF13558.6 ADV21786.1 - 0.0011 19.2 0.0 0.56 10.5 0.0 3.4 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit HEAT_2 PF13646.6 ADV21786.1 - 0.0014 19.0 9.7 0.012 16.0 0.1 3.7 4 1 0 4 4 2 1 HEAT repeats DUF3437 PF11919.8 ADV21786.1 - 0.0026 17.6 2.3 0.038 13.9 0.0 3.6 4 0 0 4 4 3 1 Domain of unknown function (DUF3437) AAA_5 PF07728.14 ADV21786.1 - 0.0028 17.6 0.7 8.6 6.4 0.2 4.5 4 0 0 4 4 4 0 AAA domain (dynein-related subfamily) AAA PF00004.29 ADV21786.1 - 0.0029 18.1 0.0 5.1 7.5 0.0 3.6 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) Chromo PF00385.24 ADV21786.1 - 0.0029 17.5 0.1 0.0029 17.5 0.1 1.9 2 0 0 2 2 1 1 Chromo (CHRromatin Organisation MOdifier) domain MMS19_C PF12460.8 ADV21786.1 - 0.0036 16.5 2.1 0.18 10.9 0.1 2.9 2 1 1 3 3 3 1 RNAPII transcription regulator C-terminal FtsK_SpoIIIE PF01580.18 ADV21786.1 - 0.0036 16.7 0.0 0.94 8.8 0.0 2.7 2 0 0 2 2 2 1 FtsK/SpoIIIE family Dynamin_N PF00350.23 ADV21786.1 - 0.0038 17.3 0.0 1.4 8.9 0.0 2.6 2 0 0 2 2 2 1 Dynamin family HEAT_EZ PF13513.6 ADV21786.1 - 0.0039 17.7 10.0 14 6.3 0.0 6.4 4 2 3 7 7 6 0 HEAT-like repeat AAA_33 PF13671.6 ADV21786.1 - 0.0046 17.1 0.0 2 8.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.22 ADV21786.1 - 0.0067 15.6 0.0 0.9 8.7 0.0 2.4 2 0 0 2 2 2 1 NB-ARC domain AAA_13 PF13166.6 ADV21786.1 - 0.0074 15.0 0.0 4.2 5.9 0.0 3.0 3 0 0 3 3 3 0 AAA domain AAA_7 PF12775.7 ADV21786.1 - 0.013 15.1 0.0 4.8 6.7 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region cobW PF02492.19 ADV21786.1 - 0.013 15.1 0.8 1.7 8.2 0.0 2.6 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Roc PF08477.13 ADV21786.1 - 0.015 15.5 0.0 6.9 6.9 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_24 PF13479.6 ADV21786.1 - 0.018 14.8 0.0 1.1 9.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 ADV21786.1 - 0.02 14.9 0.2 14 5.7 0.2 3.2 2 1 0 2 2 2 0 AAA domain AAA_30 PF13604.6 ADV21786.1 - 0.021 14.5 0.0 6.2 6.5 0.0 2.9 3 0 0 3 3 2 0 AAA domain G-alpha PF00503.20 ADV21786.1 - 0.022 13.9 0.0 6.1 5.9 0.0 2.3 2 0 0 2 2 2 0 G-protein alpha subunit NTPase_1 PF03266.15 ADV21786.1 - 0.031 14.2 0.1 12 5.8 0.1 2.5 2 0 0 2 2 2 0 NTPase ATP_bind_1 PF03029.17 ADV21786.1 - 0.042 13.6 0.3 6.9 6.4 0.0 3.0 3 0 0 3 3 2 0 Conserved hypothetical ATP binding protein CLP1_P PF16575.5 ADV21786.1 - 0.082 12.7 0.2 29 4.4 0.1 3.2 3 0 0 3 3 3 0 mRNA cleavage and polyadenylation factor CLP1 P-loop Septin PF00735.18 ADV21786.1 - 0.11 11.8 0.0 2.2 7.5 0.0 2.3 2 0 0 2 2 2 0 Septin PduV-EutP PF10662.9 ADV21786.1 - 0.12 12.1 0.0 5.5 6.7 0.0 2.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation DUF815 PF05673.13 ADV21786.1 - 0.14 11.3 0.3 12 4.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) adh_short PF00106.25 ADV21787.1 - 4.9e-40 137.1 0.0 6.1e-40 136.8 0.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ADV21787.1 - 3e-39 135.0 0.0 3.6e-39 134.7 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ADV21787.1 - 3e-05 24.0 0.1 5.7e-05 23.1 0.1 1.4 1 1 0 1 1 1 1 KR domain MMgT PF10270.9 ADV21788.1 - 2.3e-05 24.6 0.0 2.4e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 Membrane magnesium transporter Pox_A14 PF05767.12 ADV21788.1 - 0.013 15.6 1.7 0.031 14.4 1.6 1.7 1 1 0 1 1 1 0 Poxvirus virion envelope protein A14 Atthog PF18800.1 ADV21788.1 - 0.057 13.3 0.1 0.063 13.2 0.1 1.3 1 0 0 1 1 1 0 Attenuator of Hedgehog Oxidored_FMN PF00724.20 ADV21789.1 - 2e-69 234.4 0.0 2.8e-69 234.0 0.0 1.2 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family AP_endonuc_2 PF01261.24 ADV21789.1 - 0.047 13.1 0.1 0.14 11.6 0.0 1.9 2 1 0 2 2 2 0 Xylose isomerase-like TIM barrel TBCA PF02970.16 ADV21790.1 - 2.5e-24 85.4 3.2 3.2e-24 85.1 3.1 1.3 1 1 0 1 1 1 1 Tubulin binding cofactor A Spc7 PF08317.11 ADV21790.1 - 0.024 13.5 4.7 0.027 13.4 4.7 1.0 1 0 0 1 1 1 0 Spc7 kinetochore protein Efg1 PF10153.9 ADV21790.1 - 0.47 10.8 4.6 0.27 11.6 0.4 2.2 2 1 0 2 2 2 0 rRNA-processing protein Efg1 WHEP-TRS PF00458.20 ADV21790.1 - 0.95 9.7 5.4 0.63 10.2 2.9 1.9 2 0 0 2 2 2 0 WHEP-TRS domain Ureidogly_lyase PF04115.12 ADV21791.1 - 8.9e-86 286.4 0.0 2e-45 154.9 0.0 2.1 2 0 0 2 2 2 2 Ureidoglycolate lyase Allantoicase PF03561.15 ADV21791.1 - 4.2e-76 253.8 0.0 4.4e-38 130.5 0.0 2.2 2 0 0 2 2 2 2 Allantoicase repeat V_ATPase_I PF01496.19 ADV21792.1 - 0 1020.8 0.0 0 1020.6 0.0 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family MAP65_ASE1 PF03999.12 ADV21792.1 - 0.011 14.5 0.9 0.074 11.7 0.2 1.9 2 0 0 2 2 2 0 Microtubule associated protein (MAP65/ASE1 family) DUF948 PF06103.11 ADV21792.1 - 0.021 15.1 0.1 0.18 12.1 0.0 2.5 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF2096 PF09869.9 ADV21792.1 - 0.039 14.0 0.2 0.59 10.2 0.1 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2096) DUF4382 PF14321.6 ADV21792.1 - 0.13 12.5 0.0 0.22 11.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4382) DUF4200 PF13863.6 ADV21792.1 - 0.16 12.4 2.3 0.51 10.8 2.3 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) Kinesin_assoc PF16183.5 ADV21792.1 - 0.21 11.7 2.4 0.3 11.2 0.7 1.9 2 0 0 2 2 2 0 Kinesin-associated Spc7 PF08317.11 ADV21792.1 - 0.89 8.4 3.5 1.2 7.9 0.5 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein XhlA PF10779.9 ADV21792.1 - 2.1 8.6 6.7 0.66 10.2 3.4 1.9 2 0 0 2 2 2 0 Haemolysin XhlA FlaC_arch PF05377.11 ADV21792.1 - 3 8.3 5.3 2.7 8.5 1.7 2.5 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) CCDC-167 PF15188.6 ADV21792.1 - 8.7 6.8 6.7 18 5.7 1.7 2.6 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 SF3A2 PF16835.5 ADV21794.1 - 8.2e-35 119.1 0.0 1.4e-34 118.3 0.0 1.4 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) zf-met PF12874.7 ADV21794.1 - 2.5e-05 24.5 0.6 4.8e-05 23.6 0.6 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type PRP4 PF08799.11 ADV21794.1 - 0.023 14.2 1.0 0.058 13.0 1.0 1.7 1 0 0 1 1 1 0 pre-mRNA processing factor 4 (PRP4) like Lactamase_B_6 PF16661.5 ADV21795.1 - 2.1e-55 187.2 0.0 2.9e-55 186.7 0.0 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain CPSF100_C PF13299.6 ADV21795.1 - 8.7e-29 100.9 0.1 4e-26 92.2 0.0 3.6 3 1 0 3 3 3 1 Cleavage and polyadenylation factor 2 C-terminal Beta-Casp PF10996.8 ADV21795.1 - 1.1e-16 61.0 0.0 2.8e-16 59.8 0.0 1.7 1 0 0 1 1 1 1 Beta-Casp domain RMMBL PF07521.12 ADV21795.1 - 1.2e-06 28.4 0.0 2.8e-06 27.2 0.0 1.6 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Ipi1_N PF12333.8 ADV21796.1 - 3.6e-10 40.4 0.3 2.8e-09 37.5 0.1 2.5 1 1 1 2 2 2 1 Rix1 complex component involved in 60S ribosome maturation Cnd1 PF12717.7 ADV21796.1 - 0.022 14.8 0.0 0.037 14.1 0.0 1.3 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 adh_short PF00106.25 ADV21797.1 - 1.2e-34 119.5 0.1 1.7e-34 119.0 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ADV21797.1 - 1.4e-28 100.1 0.0 2.7e-28 99.1 0.0 1.4 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ADV21797.1 - 0.00012 22.0 0.1 0.00017 21.5 0.1 1.3 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 ADV21797.1 - 0.096 12.0 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Methyltransf_25 PF13649.6 ADV21797.1 - 0.1 13.3 0.0 0.22 12.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Abhydrolase_1 PF00561.20 ADV21798.1 - 1.7e-14 54.1 0.0 5.3e-12 45.9 0.1 2.1 1 1 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ADV21798.1 - 1.5e-12 47.4 0.1 3.1e-10 39.7 0.1 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 BAAT_C PF08840.11 ADV21798.1 - 1.1e-07 32.0 0.0 0.00029 20.8 0.0 3.1 3 0 0 3 3 3 2 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_6 PF12697.7 ADV21798.1 - 3.8e-05 24.4 0.0 5.4e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 ADV21798.1 - 0.0021 17.6 0.0 0.0049 16.4 0.0 1.5 1 1 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.18 ADV21798.1 - 0.0038 16.8 0.0 1.2 8.7 0.0 2.5 3 0 0 3 3 3 2 Dienelactone hydrolase family Esterase PF00756.20 ADV21798.1 - 0.045 13.4 0.0 0.089 12.4 0.0 1.5 1 1 0 1 1 1 0 Putative esterase FSH1 PF03959.13 ADV21798.1 - 0.059 13.0 0.0 0.1 12.2 0.0 1.5 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.16 ADV21798.1 - 0.084 12.7 0.0 0.19 11.5 0.0 1.7 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase PAF-AH_p_II PF03403.13 ADV21798.1 - 0.13 10.8 0.0 0.2 10.2 0.0 1.2 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II CWC25 PF12542.8 ADV21799.1 - 8.3e-23 81.2 0.0 8.3e-23 81.2 0.0 3.7 4 1 0 4 4 4 1 Pre-mRNA splicing factor Cir_N PF10197.9 ADV21799.1 - 1.4e-12 47.6 9.5 1.4e-12 47.6 9.5 4.5 5 1 1 6 6 6 1 N-terminal domain of CBF1 interacting co-repressor CIR CAP_N PF01213.19 ADV21800.1 - 0.34 10.4 0.8 0.43 10.0 0.8 1.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal GTP_EFTU PF00009.27 ADV21801.1 - 1.7e-46 158.3 0.1 2.7e-46 157.6 0.1 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFTUD2 PF16004.5 ADV21801.1 - 1.5e-35 122.4 1.3 2.5e-35 121.7 1.3 1.3 1 0 0 1 1 1 1 116 kDa U5 small nuclear ribonucleoprotein component N-terminus EFG_IV PF03764.18 ADV21801.1 - 5.6e-25 87.5 0.0 1.3e-24 86.3 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.24 ADV21801.1 - 1.8e-22 79.1 0.0 6.4e-22 77.4 0.0 2.0 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 ADV21801.1 - 5.2e-09 36.4 0.4 1.6e-08 34.8 0.4 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 ADV21801.1 - 1.4e-06 28.4 0.3 2.7e-06 27.4 0.3 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase EFG_II PF14492.6 ADV21801.1 - 3.3e-05 23.9 0.1 8.3e-05 22.6 0.1 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II Septin PF00735.18 ADV21801.1 - 0.0041 16.5 0.2 0.007 15.7 0.2 1.3 1 0 0 1 1 1 1 Septin Ras PF00071.22 ADV21801.1 - 0.0098 15.5 0.2 0.032 13.8 0.2 1.8 1 1 0 1 1 1 1 Ras family SRPRB PF09439.10 ADV21801.1 - 0.014 14.9 0.1 0.066 12.6 0.1 2.1 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit Roc PF08477.13 ADV21801.1 - 0.072 13.3 0.2 0.29 11.3 0.2 2.0 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase CDH-cyt PF16010.5 ADV21802.1 - 9.4e-13 48.2 5.4 4.7e-12 46.0 5.4 2.0 1 1 0 1 1 1 1 Cytochrome domain of cellobiose dehydrogenase Cytochrom_B561 PF03188.16 ADV21802.1 - 8.3e-08 32.5 5.5 1.8e-07 31.4 5.5 1.5 1 0 0 1 1 1 1 Eukaryotic cytochrome b561 DOMON PF03351.17 ADV21802.1 - 8.1e-07 29.3 0.1 1.7e-06 28.3 0.1 1.5 1 0 0 1 1 1 1 DOMON domain DUF2427 PF10348.9 ADV21802.1 - 1.1e-06 28.4 0.3 2.6e-06 27.2 0.3 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF2427) DUF4079 PF13301.6 ADV21802.1 - 0.007 16.5 3.4 0.62 10.2 0.2 2.6 1 1 1 2 2 2 2 Protein of unknown function (DUF4079) DUF4010 PF13194.6 ADV21802.1 - 0.036 13.7 2.0 0.059 13.0 1.5 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4010) DUF202 PF02656.15 ADV21802.1 - 0.35 11.4 12.2 0.19 12.2 1.2 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF202) DUF3681 PF12442.8 ADV21802.1 - 0.55 10.7 8.2 0.04 14.4 2.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3681) DUF2306 PF10067.9 ADV21802.1 - 0.57 10.4 9.0 3.4 7.9 1.4 3.0 3 0 0 3 3 3 0 Predicted membrane protein (DUF2306) COX15-CtaA PF02628.15 ADV21802.1 - 0.84 8.6 9.6 1.5 7.8 9.6 1.4 1 0 0 1 1 1 0 Cytochrome oxidase assembly protein Tetraspanin PF00335.20 ADV21802.1 - 5.3 6.7 7.9 16 5.1 0.8 3.2 3 0 0 3 3 3 0 Tetraspanin family zf-C3HC4_3 PF13920.6 ADV21803.1 - 1.7e-11 43.8 6.3 1.1e-09 37.9 1.5 2.2 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ADV21803.1 - 7.5e-05 22.5 4.4 7.5e-05 22.5 4.4 2.2 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 ADV21803.1 - 0.00036 20.8 5.9 0.0008 19.7 1.7 2.3 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.6 ADV21803.1 - 0.014 15.4 3.0 0.072 13.1 0.5 2.2 2 0 0 2 2 2 0 zinc-RING finger domain zf-RING_UBOX PF13445.6 ADV21803.1 - 0.042 13.9 3.6 1.6 8.8 0.4 2.5 2 0 0 2 2 2 0 RING-type zinc-finger zf-C3HC4_2 PF13923.6 ADV21803.1 - 1.7 8.5 5.9 0.68 9.8 2.1 2.0 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) RRM_1 PF00076.22 ADV21804.1 - 0.055 13.3 0.0 0.11 12.3 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) UQ_con PF00179.26 ADV21805.1 - 1.4e-42 144.6 0.0 2.3e-42 144.0 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 ADV21805.1 - 0.0012 18.7 0.0 0.002 18.0 0.0 1.3 1 0 0 1 1 1 1 UEV domain Prok-E2_B PF14461.6 ADV21805.1 - 0.0012 18.5 0.0 0.0018 18.0 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B Complex1_LYR PF05347.15 ADV21805.1 - 0.023 14.7 0.0 0.036 14.1 0.0 1.3 1 0 0 1 1 1 0 Complex 1 protein (LYR family) PCI PF01399.27 ADV21806.1 - 3.3e-17 62.9 0.0 9.4e-17 61.5 0.0 1.8 1 0 0 1 1 1 1 PCI domain RPN5_C PF18098.1 ADV21806.1 - 8.4e-14 51.4 0.6 2e-13 50.2 0.6 1.7 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN5 C-terminal domain HpcH_HpaI PF03328.14 ADV21807.1 - 1.2e-34 119.4 0.0 1.4e-34 119.2 0.0 1.0 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family Ribonuc_L-PSP PF01042.21 ADV21808.1 - 1.1e-24 86.8 0.0 1.3e-24 86.5 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP XdhC_CoxI PF02625.16 ADV21808.1 - 0.053 13.7 0.0 0.084 13.1 0.0 1.3 1 0 0 1 1 1 0 XdhC and CoxI family Aldedh PF00171.22 ADV21809.1 - 2.9e-126 421.7 0.0 3.3e-126 421.5 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 ADV21809.1 - 0.0069 15.5 0.0 0.012 14.7 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA reductase (LuxC) YCII PF03795.14 ADV21809.1 - 0.034 14.5 0.0 0.11 12.9 0.0 1.9 1 1 0 2 2 2 0 YCII-related domain Aa_trans PF01490.18 ADV21810.1 - 4.1e-36 124.6 28.8 5.2e-36 124.2 28.8 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Fungal_trans PF04082.18 ADV21811.1 - 1.9e-17 63.2 1.1 1.7e-09 37.2 0.1 2.4 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 ADV21811.1 - 3.4e-09 36.7 10.5 8.8e-09 35.4 10.5 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF1299 PF06975.11 ADV21811.1 - 0.098 12.7 0.1 0.24 11.5 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1299) E1_DerP2_DerF2 PF02221.15 ADV21812.1 - 5.2e-23 82.0 0.1 6.1e-23 81.7 0.1 1.1 1 0 0 1 1 1 1 ML domain Glyco_hydro_71 PF03659.14 ADV21814.1 - 1.4e-86 290.7 0.0 1.6e-86 290.5 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 71 Raptor_N PF14538.6 ADV21816.1 - 7e-65 217.5 0.0 1.2e-64 216.7 0.0 1.4 1 0 0 1 1 1 1 Raptor N-terminal CASPase like domain WD40 PF00400.32 ADV21816.1 - 6.9e-05 23.5 7.5 0.077 13.9 0.1 5.5 6 0 0 6 6 6 2 WD domain, G-beta repeat HEAT PF02985.22 ADV21816.1 - 0.001 19.2 1.3 0.075 13.3 0.0 4.2 4 0 0 4 4 4 1 HEAT repeat HEAT_EZ PF13513.6 ADV21816.1 - 0.042 14.4 0.1 3.4 8.3 0.0 3.2 2 0 0 2 2 2 0 HEAT-like repeat Pkinase PF00069.25 ADV21817.1 - 2.3e-48 164.9 0.0 2.6e-47 161.4 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV21817.1 - 4.5e-20 72.0 0.0 1.4e-17 63.8 0.0 2.4 2 1 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 ADV21817.1 - 0.0003 20.2 0.0 0.00049 19.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 ADV21817.1 - 0.0031 17.5 0.1 0.006 16.5 0.1 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 ADV21817.1 - 0.0031 16.9 0.0 0.0053 16.1 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 ADV21817.1 - 0.0042 15.9 0.0 0.0082 15.0 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Sugar_tr PF00083.24 ADV21819.1 - 4.2e-58 197.3 17.3 5e-58 197.1 17.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ADV21819.1 - 1.6e-13 50.3 34.7 2.5e-13 49.7 34.7 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily ATP-synt_J PF04911.12 ADV21819.1 - 0.24 11.0 0.6 9.1 6.0 0.1 2.5 2 0 0 2 2 2 0 ATP synthase j chain Nefa_Nip30_N PF10187.9 ADV21820.1 - 0.09 13.1 0.1 19 5.7 0.1 2.4 2 0 0 2 2 2 0 N-terminal domain of NEFA-interacting nuclear protein NIP30 PCI PF01399.27 ADV21821.1 - 9.6e-23 80.7 1.0 2.6e-22 79.3 0.4 2.1 2 0 0 2 2 2 1 PCI domain TPR_10 PF13374.6 ADV21821.1 - 0.028 14.3 0.1 2.1 8.3 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 ADV21821.1 - 0.13 12.9 3.0 3.1 8.6 0.2 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat YL1 PF05764.13 ADV21821.1 - 2.2 8.3 5.0 3.4 7.7 5.0 1.3 1 0 0 1 1 1 0 YL1 nuclear protein Sugar_tr PF00083.24 ADV21822.1 - 8.1e-35 120.5 24.8 7.3e-21 74.6 7.5 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 ADV21822.1 - 2.7e-15 56.2 36.7 1e-08 34.5 14.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Nup160 PF11715.8 ADV21823.1 - 7.8e-45 153.5 0.0 1.1e-44 153.0 0.0 1.2 1 0 0 1 1 1 1 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ADV21823.1 - 0.0033 16.3 0.0 0.0053 15.6 0.0 1.3 1 0 0 1 1 1 1 Nup133 N terminal like TPR_16 PF13432.6 ADV21823.1 - 0.35 11.6 2.4 0.57 10.9 0.4 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat Galactosyl_T PF01762.21 ADV21824.1 - 1.2e-08 35.1 0.3 0.0031 17.3 0.2 2.3 1 1 1 2 2 2 2 Galactosyltransferase RRM_1 PF00076.22 ADV21825.1 - 4.8e-10 39.1 0.0 1.5e-06 27.9 0.0 2.7 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RL PF17797.1 ADV21825.1 - 0.018 15.0 0.0 0.042 13.8 0.0 1.6 1 0 0 1 1 1 0 RL domain Chromo_2 PF18704.1 ADV21826.1 - 0.0085 16.3 0.1 0.013 15.8 0.1 1.3 1 0 0 1 1 1 1 Chromatin organization modifier domain 2 Glycolipid_bind PF06475.11 ADV21826.1 - 0.048 13.2 0.0 0.059 12.9 0.0 1.2 1 0 0 1 1 1 0 Putative glycolipid-binding PPR_2 PF13041.6 ADV21827.1 - 4.7e-11 42.7 0.2 0.36 11.1 0.0 7.3 8 1 1 9 9 9 3 PPR repeat family PPR PF01535.20 ADV21827.1 - 4e-10 39.2 5.0 0.011 15.9 0.0 7.3 7 1 0 7 7 7 3 PPR repeat PPR_1 PF12854.7 ADV21827.1 - 5.4e-05 22.8 3.0 1.5 8.6 0.4 4.7 5 0 0 5 5 5 2 PPR repeat ATP13 PF12921.7 ADV21827.1 - 0.012 15.5 0.0 0.33 10.8 0.0 3.0 3 0 0 3 3 3 0 Mitochondrial ATPase expression PPR_3 PF13812.6 ADV21827.1 - 0.097 12.8 0.0 13 5.9 0.0 3.9 4 0 0 4 4 4 0 Pentatricopeptide repeat domain RPN1_RPN2_N PF17781.1 ADV21827.1 - 0.17 11.3 0.8 2.4 7.5 0.1 2.6 2 1 1 3 3 3 0 RPN1/RPN2 N-terminal domain Prenyltrans PF00432.21 ADV21828.1 - 2.5e-55 183.9 9.8 3.1e-12 46.0 0.2 6.1 6 0 0 6 6 6 6 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_N PF13249.6 ADV21828.1 - 0.0039 16.3 0.0 7.5 5.6 0.0 3.4 2 1 2 4 4 4 3 Squalene-hopene cyclase N-terminal domain EXOSC1 PF10447.9 ADV21829.1 - 3.4e-14 53.4 0.8 9.4e-13 48.7 0.8 2.2 1 1 0 1 1 1 1 Exosome component EXOSC1/CSL4 ECR1_N PF14382.6 ADV21829.1 - 0.00084 19.1 0.1 0.0029 17.3 0.1 2.0 1 1 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region TB2_DP1_HVA22 PF03134.19 ADV21830.1 - 7.5e-17 61.0 0.0 1.4e-16 60.2 0.0 1.4 1 0 0 1 1 1 1 TB2/DP1, HVA22 family DUF2705 PF10920.8 ADV21830.1 - 0.11 11.8 1.1 0.15 11.3 1.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2705) SPX PF03105.19 ADV21830.1 - 1.5 8.6 15.3 3.9 7.3 11.3 2.1 2 0 0 2 2 2 0 SPX domain Syntaxin-6_N PF09177.11 ADV21832.1 - 4.5e-20 72.0 1.8 1.8e-19 70.1 0.4 2.0 2 0 0 2 2 2 1 Syntaxin 6, N-terminal DUF4407 PF14362.6 ADV21832.1 - 0.00017 21.1 0.0 0.00019 20.9 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) V-SNARE_C PF12352.8 ADV21832.1 - 0.0029 17.8 3.4 0.021 15.1 0.5 2.9 2 2 1 3 3 3 1 Snare region anchored in the vesicle membrane C-terminus DUF745 PF05335.13 ADV21832.1 - 0.0037 17.0 0.2 0.01 15.6 0.2 1.6 1 1 1 2 2 2 2 Protein of unknown function (DUF745) Spc7 PF08317.11 ADV21832.1 - 0.022 13.6 1.9 0.029 13.3 1.9 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein STAT_alpha PF01017.20 ADV21832.1 - 0.028 14.3 0.2 3 7.7 0.0 2.3 2 0 0 2 2 2 0 STAT protein, all-alpha domain FliJ PF02050.16 ADV21832.1 - 0.031 14.5 0.2 0.4 10.9 0.1 2.1 1 1 2 3 3 3 0 Flagellar FliJ protein SNARE PF05739.19 ADV21832.1 - 0.034 14.2 0.2 0.034 14.2 0.2 3.6 4 0 0 4 4 4 0 SNARE domain PspA_IM30 PF04012.12 ADV21832.1 - 0.049 13.2 0.6 1 8.9 0.1 2.2 2 0 0 2 2 2 0 PspA/IM30 family Prominin PF05478.11 ADV21832.1 - 0.054 11.5 0.8 0.096 10.6 0.8 1.5 1 1 0 1 1 1 0 Prominin Nnf1 PF03980.14 ADV21832.1 - 0.058 13.8 1.6 5.5 7.4 0.1 2.4 1 1 1 2 2 2 0 Nnf1 Innexin PF00876.18 ADV21832.1 - 0.093 12.0 0.1 0.12 11.6 0.0 1.3 1 1 0 1 1 1 0 Innexin Laminin_II PF06009.12 ADV21832.1 - 0.11 12.5 1.9 1.5 8.9 0.2 2.3 1 1 1 2 2 2 0 Laminin Domain II Phage_GP20 PF06810.11 ADV21832.1 - 0.12 12.1 0.2 1.8 8.4 0.0 2.2 2 1 0 2 2 2 0 Phage minor structural protein GP20 Picorna_P3A PF06363.11 ADV21832.1 - 0.13 12.2 0.0 0.4 10.6 0.0 1.8 2 0 0 2 2 2 0 Picornaviridae P3A protein Snapin_Pallidin PF14712.6 ADV21832.1 - 0.15 12.5 4.7 0.82 10.1 0.1 2.8 2 1 0 2 2 2 0 Snapin/Pallidin DUF4559 PF15112.6 ADV21832.1 - 0.16 11.6 3.2 0.26 10.9 0.9 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4559) DUF16 PF01519.16 ADV21832.1 - 0.24 11.9 2.0 7.2 7.2 1.3 2.3 1 1 1 2 2 2 0 Protein of unknown function DUF16 NPV_P10 PF05531.12 ADV21832.1 - 0.28 11.7 2.4 12 6.4 0.2 3.0 1 1 3 4 4 4 0 Nucleopolyhedrovirus P10 protein EMP24_GP25L PF01105.24 ADV21832.1 - 0.28 11.1 5.7 0.21 11.5 0.2 2.3 1 1 0 2 2 2 0 emp24/gp25L/p24 family/GOLD COG5 PF10392.9 ADV21832.1 - 0.3 11.3 4.6 6.3 7.0 0.3 2.6 1 1 0 2 2 2 0 Golgi transport complex subunit 5 SlyX PF04102.12 ADV21832.1 - 0.69 10.6 5.1 9.2 7.0 0.1 3.1 2 1 1 3 3 3 0 SlyX DUF1664 PF07889.12 ADV21832.1 - 0.92 9.6 4.6 5.1 7.2 1.0 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) FlaC_arch PF05377.11 ADV21832.1 - 1.5 9.3 7.1 7.9 7.0 0.3 3.8 3 1 2 5 5 4 0 Flagella accessory protein C (FlaC) Sec7 PF01369.20 ADV21834.1 - 2.8e-72 242.3 1.4 7.3e-72 240.9 1.4 1.8 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 ADV21834.1 - 8.9e-44 149.2 6.3 8.9e-44 149.2 6.3 3.4 3 0 0 3 3 3 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.10 ADV21834.1 - 2.8e-33 113.6 9.4 2.8e-31 107.2 0.3 5.6 6 0 0 6 6 6 2 Domain of unknown function (DUF1981) DCB PF16213.5 ADV21834.1 - 8.2e-13 48.4 0.0 1.4e-11 44.4 0.0 2.7 2 0 0 2 2 2 1 Dimerisation and cyclophilin-binding domain of Mon2 Peptidase_M64 PF09471.10 ADV21835.1 - 1.5e-12 47.6 0.0 5.6e-12 45.8 0.0 1.8 1 1 0 1 1 1 1 IgA Peptidase M64 HAGH_C PF16123.5 ADV21836.1 - 2.3e-20 72.9 0.1 4.1e-20 72.1 0.1 1.4 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.27 ADV21836.1 - 9.6e-11 42.0 0.5 6.8e-10 39.3 0.5 2.0 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_3 PF13483.6 ADV21836.1 - 0.033 14.1 0.2 0.081 12.8 0.0 1.7 2 0 0 2 2 2 0 Beta-lactamase superfamily domain Lactamase_B_2 PF12706.7 ADV21836.1 - 0.042 13.3 0.8 0.24 10.9 0.8 2.0 1 1 0 1 1 1 0 Beta-lactamase superfamily domain ACT PF01842.25 ADV21836.1 - 0.22 11.3 0.2 1.1 9.1 0.0 2.2 2 0 0 2 2 2 0 ACT domain SQHop_cyclase_C PF13243.6 ADV21837.1 - 1.2e-52 179.0 2.7 8.9e-51 172.9 4.1 2.2 2 0 0 2 2 2 1 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 ADV21837.1 - 1.5e-49 168.7 0.4 3.3e-40 138.0 0.0 4.0 3 1 1 4 4 4 3 Squalene-hopene cyclase N-terminal domain Prenyltrans PF00432.21 ADV21837.1 - 3.5e-36 122.6 2.2 3.2e-10 39.6 0.1 6.1 6 0 0 6 6 6 4 Prenyltransferase and squalene oxidase repeat TED_complement PF07678.14 ADV21837.1 - 7.1e-05 22.0 0.9 0.0014 17.7 0.0 2.6 2 1 0 2 2 2 1 A-macroglobulin TED domain Pec_lyase PF09492.10 ADV21837.1 - 0.0053 16.1 0.5 1.1 8.5 0.0 3.6 2 1 2 4 4 4 1 Pectic acid lyase zf-CCCH PF00642.24 ADV21838.1 - 6.1e-07 29.2 11.1 0.00077 19.3 2.5 2.5 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Ank_2 PF12796.7 ADV21838.1 - 2.2e-06 28.2 0.0 4.1e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) zf_CCCH_4 PF18345.1 ADV21838.1 - 6e-06 26.1 12.8 0.0024 17.9 5.6 2.7 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH_4 PF18044.1 ADV21838.1 - 0.00013 21.7 14.8 0.0072 16.1 2.5 2.5 2 0 0 2 2 2 2 CCCH-type zinc finger zf-CCCH_2 PF14608.6 ADV21838.1 - 0.0003 21.1 7.0 0.0003 21.1 7.0 2.6 2 0 0 2 2 2 1 RNA-binding, Nab2-type zinc finger Ank_3 PF13606.6 ADV21838.1 - 0.00055 20.2 0.2 0.052 14.1 0.1 2.6 2 0 0 2 2 2 1 Ankyrin repeat Torus PF16131.5 ADV21838.1 - 0.0015 19.2 1.5 0.044 14.5 0.2 2.6 2 0 0 2 2 2 1 Torus domain Ank_4 PF13637.6 ADV21838.1 - 0.0047 17.5 0.0 0.0089 16.6 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 ADV21838.1 - 0.005 17.2 0.4 0.14 12.6 0.1 2.6 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.6 ADV21838.1 - 0.014 15.7 0.4 0.061 13.7 0.1 2.1 1 1 1 2 2 2 0 Ankyrin repeats (many copies) Spt20 PF12090.8 ADV21838.1 - 2.1 7.9 5.1 5.3 6.6 5.1 1.6 1 0 0 1 1 1 0 Spt20 family CEP63 PF17045.5 ADV21838.1 - 8.6 6.2 7.7 0.33 10.8 0.3 1.9 2 0 0 2 2 2 0 Centrosomal protein of 63 kDa RAI16-like PF10257.9 ADV21840.1 - 8.7e-105 350.5 0.0 1.3e-104 349.9 0.0 1.3 1 0 0 1 1 1 1 Retinoic acid induced 16-like protein Serglycin PF04360.12 ADV21840.1 - 0.11 12.5 0.5 0.24 11.3 0.5 1.5 1 0 0 1 1 1 0 Serglycin ECH_1 PF00378.20 ADV21841.1 - 2e-32 112.5 1.1 2.7e-32 112.1 1.1 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ADV21841.1 - 9.4e-22 77.9 0.2 1.6e-21 77.2 0.2 1.4 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase T2SSS_2 PF16549.5 ADV21841.1 - 0.021 14.8 0.2 0.037 14.0 0.2 1.4 1 0 0 1 1 1 0 Type II secretion system (T2SS) pilotin, S protein DnaG_DnaB_bind PF08278.11 ADV21841.1 - 0.11 13.0 0.0 0.19 12.3 0.0 1.4 1 0 0 1 1 1 0 DNA primase DnaG DnaB-binding NodA PF02474.15 ADV21841.1 - 0.12 12.1 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 Nodulation protein A (NodA) KH_6 PF15985.5 ADV21842.1 - 7.8e-15 55.0 0.2 1.5e-14 54.0 0.2 1.5 1 0 0 1 1 1 1 KH domain Rrp40_N PF18311.1 ADV21842.1 - 2.6e-14 52.9 1.6 4.5e-14 52.1 1.6 1.4 1 0 0 1 1 1 1 Exosome complex exonuclease Rrp40 N-terminal domain MMM1 PF10296.9 ADV21843.1 - 0.00027 20.1 0.0 0.00027 20.1 0.0 2.7 3 0 0 3 3 3 1 Maintenance of mitochondrial morphology protein 1 PH PF00169.29 ADV21843.1 - 0.0044 17.5 0.0 0.014 15.9 0.0 1.9 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 ADV21843.1 - 0.0085 16.5 0.0 0.15 12.5 0.0 3.2 2 1 0 2 2 2 1 Pleckstrin homology domain Rep_fac-A_C PF08646.10 ADV21844.1 - 2.2e-49 166.9 3.5 9.9e-48 161.6 1.6 2.5 2 0 0 2 2 2 2 Replication factor-A C terminal domain REPA_OB_2 PF16900.5 ADV21844.1 - 1.1e-25 89.4 5.3 1.6e-23 82.4 0.0 3.7 3 1 1 4 4 4 2 Replication protein A OB domain Rep-A_N PF04057.12 ADV21844.1 - 4.1e-24 84.5 0.5 7.7e-24 83.6 0.5 1.4 1 0 0 1 1 1 1 Replication factor-A protein 1, N-terminal domain tRNA_anti-codon PF01336.25 ADV21844.1 - 1.1e-12 47.7 3.3 4.5e-10 39.4 0.2 4.1 4 1 1 5 5 5 1 OB-fold nucleic acid binding domain CDC24_OB3 PF17244.2 ADV21844.1 - 0.00019 21.2 0.1 0.21 11.3 0.0 2.5 2 0 0 2 2 2 2 Cell division control protein 24, OB domain 3 DUF4539 PF15072.6 ADV21844.1 - 0.0034 17.4 0.0 0.0087 16.1 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4539) Nrap_D4 PF17405.2 ADV21845.1 - 7.7e-52 175.7 0.0 1.6e-51 174.7 0.0 1.6 1 1 0 1 1 1 1 Nrap protein nucleotidyltransferase domain 4 Nrap_D5 PF17406.2 ADV21845.1 - 2.7e-41 141.0 0.0 2.2e-40 138.0 0.0 2.2 2 0 0 2 2 2 1 Nrap protein PAP/OAS1-like domain 5 Nrap_D6 PF17407.2 ADV21845.1 - 3.5e-38 130.9 0.0 6.5e-38 130.0 0.0 1.5 1 0 0 1 1 1 1 Nrap protein domain 6 Nrap_D2 PF17403.2 ADV21845.1 - 1.2e-35 122.5 0.0 2.7e-32 111.6 0.0 2.9 3 0 0 3 3 3 2 Nrap protein PAP/OAS-like domain Nrap_D3 PF17404.2 ADV21845.1 - 2.4e-35 122.0 0.0 4.6e-35 121.0 0.0 1.4 1 0 0 1 1 1 1 Nrap protein domain 3 Nrap PF03813.14 ADV21845.1 - 5e-35 120.8 0.0 8.4e-35 120.1 0.0 1.4 1 0 0 1 1 1 1 Nrap protein domain 1 FKBP_C PF00254.28 ADV21846.1 - 3e-28 98.0 0.0 7.1e-28 96.8 0.0 1.7 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase NPL PF17800.1 ADV21846.1 - 4.8e-20 72.1 7.8 4.8e-20 72.1 7.8 2.6 2 1 0 2 2 2 1 Nucleoplasmin-like domain Utp14 PF04615.13 ADV21846.1 - 0.088 11.4 31.9 0.14 10.7 31.9 1.2 1 0 0 1 1 1 0 Utp14 protein TFIIF_alpha PF05793.12 ADV21846.1 - 0.31 9.6 41.5 0.35 9.4 18.9 2.1 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF3915 PF13054.6 ADV21846.1 - 1 9.4 4.2 1.9 8.4 4.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Kelch_1 PF01344.25 ADV21847.1 - 8.2e-32 108.5 3.9 1.4e-07 30.9 0.4 6.5 6 0 0 6 6 6 5 Kelch motif Kelch_3 PF13415.6 ADV21847.1 - 8.8e-32 108.8 0.8 7.1e-09 35.7 0.2 5.9 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_6 PF13964.6 ADV21847.1 - 5.3e-31 105.9 3.2 5e-08 32.9 0.3 6.8 4 1 2 6 6 6 6 Kelch motif Kelch_4 PF13418.6 ADV21847.1 - 5.9e-31 106.2 11.0 7e-09 35.6 0.8 6.9 5 1 1 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.6 ADV21847.1 - 2.2e-26 91.3 4.9 0.00012 22.0 0.2 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_2 PF07646.15 ADV21847.1 - 3.8e-17 61.5 9.8 0.00058 19.7 0.2 6.4 6 1 0 6 6 6 5 Kelch motif 2H-phosphodiest PF08975.10 ADV21847.1 - 0.03 14.3 0.0 0.09 12.7 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1868) DUF1308 PF07000.11 ADV21847.1 - 0.13 12.2 3.9 2.8 7.8 0.7 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1308) UQ_con PF00179.26 ADV21848.1 - 1.7e-44 150.9 0.1 1.8e-44 150.8 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 ADV21848.1 - 0.00021 21.6 0.0 0.00026 21.3 0.0 1.2 1 0 0 1 1 1 1 RWD domain Prok-E2_B PF14461.6 ADV21848.1 - 0.00092 18.9 0.0 0.001 18.8 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B NapB PF03892.14 ADV21848.1 - 0.028 14.4 0.0 0.043 13.8 0.0 1.3 1 0 0 1 1 1 0 Nitrate reductase cytochrome c-type subunit (NapB) UEV PF05743.13 ADV21848.1 - 0.074 12.9 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 UEV domain Ribosomal_S13_N PF08069.12 ADV21849.1 - 6.7e-27 93.3 0.1 1.4e-26 92.3 0.1 1.6 1 0 0 1 1 1 1 Ribosomal S13/S15 N-terminal domain Ribosomal_S15 PF00312.22 ADV21849.1 - 7e-13 48.6 0.5 9.9e-13 48.1 0.5 1.2 1 0 0 1 1 1 1 Ribosomal protein S15 YfhE PF14152.6 ADV21850.1 - 0.073 13.2 0.6 0.22 11.6 0.1 2.0 2 0 0 2 2 2 0 YfhE-like protein Glyco_transf_90 PF05686.12 ADV21851.1 - 4.2e-06 25.9 0.5 6.8e-06 25.2 0.0 1.5 2 0 0 2 2 2 1 Glycosyl transferase family 90 PAP_assoc PF03828.19 ADV21852.1 - 0.0001 22.4 0.1 0.0046 17.1 0.0 2.4 1 1 1 2 2 2 2 Cid1 family poly A polymerase Asp_Glu_race PF01177.22 ADV21853.1 - 1e-08 35.3 0.0 2.3e-08 34.1 0.0 1.6 1 1 0 1 1 1 1 Asp/Glu/Hydantoin racemase Utp21 PF04192.12 ADV21854.1 - 1.4e-75 253.8 0.1 2.3e-75 253.1 0.1 1.3 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain ANAPC4_WD40 PF12894.7 ADV21854.1 - 9.5e-17 61.1 0.1 4e-05 23.8 0.1 7.0 3 2 4 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ADV21854.1 - 2.3e-15 56.7 13.5 0.0086 16.9 0.3 9.5 10 1 0 10 10 10 3 WD domain, G-beta repeat Utp12 PF04003.12 ADV21854.1 - 9.8e-06 25.8 0.1 2.3e-05 24.6 0.1 1.6 2 0 0 2 2 2 1 Dip2/Utp12 Family eIF2A PF08662.11 ADV21854.1 - 0.00074 19.4 0.0 0.89 9.4 0.0 3.5 3 2 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ADV21854.1 - 0.022 14.1 0.0 4.4 6.5 0.0 2.8 3 0 0 3 3 3 0 WD40-like domain Nucleoporin_N PF08801.11 ADV21854.1 - 0.068 11.9 2.5 6.5 5.4 0.0 3.6 2 1 1 3 3 3 0 Nup133 N terminal like VID27 PF08553.10 ADV21854.1 - 0.13 11.3 0.0 1.1 8.2 0.0 2.4 1 1 1 2 2 2 0 VID27 C-terminal WD40-like domain SF1-HH PF16275.5 ADV21855.1 - 3.3e-40 136.9 0.3 6.9e-40 135.9 0.3 1.6 1 0 0 1 1 1 1 Splicing factor 1 helix-hairpin domain zf-CCHC PF00098.23 ADV21855.1 - 4.6e-09 35.9 11.0 8.5e-05 22.5 1.6 2.4 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_3 PF13917.6 ADV21855.1 - 2.5e-07 30.5 7.5 0.00017 21.5 3.7 2.4 1 1 1 2 2 2 2 Zinc knuckle KH_1 PF00013.29 ADV21855.1 - 2.4e-06 27.2 0.0 4.7e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 KH domain zf-CCHC_2 PF13696.6 ADV21855.1 - 0.00027 20.7 11.9 0.022 14.6 3.5 2.4 2 0 0 2 2 2 2 Zinc knuckle CCDC-167 PF15188.6 ADV21855.1 - 0.0053 17.1 0.8 0.86 10.0 0.0 2.4 2 0 0 2 2 2 1 Coiled-coil domain-containing protein 167 zf-CCHC_4 PF14392.6 ADV21855.1 - 0.18 11.5 5.8 5.7 6.8 1.5 2.4 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_6 PF15288.6 ADV21855.1 - 0.19 11.6 9.6 1 9.2 0.3 2.6 1 1 1 2 2 2 0 Zinc knuckle SIS PF01380.22 ADV21856.1 - 3.3e-63 211.4 0.1 1.4e-30 105.8 0.0 2.4 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.6 ADV21856.1 - 7.9e-16 58.5 0.0 1.6e-15 57.4 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 ADV21856.1 - 6.9e-13 48.6 0.0 1.4e-12 47.6 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.6 ADV21856.1 - 0.00059 18.8 0.0 0.001 18.0 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II UreD PF01774.17 ADV21857.1 - 3.5e-56 190.5 0.0 4.3e-56 190.2 0.0 1.1 1 0 0 1 1 1 1 UreD urease accessory protein DKCLD PF08068.12 ADV21858.1 - 4.9e-33 113.0 2.3 4e-31 106.9 0.3 2.8 3 0 0 3 3 3 2 DKCLD (NUC011) domain TruB_N PF01509.18 ADV21858.1 - 5.3e-24 85.3 0.3 5.4e-21 75.5 0.3 3.6 1 1 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) PUA PF01472.20 ADV21858.1 - 7.9e-23 80.2 1.8 2e-22 78.9 1.8 1.7 1 0 0 1 1 1 1 PUA domain TruB_C_2 PF16198.5 ADV21858.1 - 8.4e-23 80.3 0.5 2e-22 79.1 0.5 1.7 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain UPF0113 PF03657.13 ADV21858.1 - 0.00038 20.7 0.0 0.001 19.3 0.0 1.8 1 0 0 1 1 1 1 UPF0113 PUA domain RNA_polI_A34 PF08208.11 ADV21858.1 - 1.5 8.9 26.9 3 7.9 26.9 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Ribosomal_S17e PF00833.18 ADV21859.1 - 2.2e-58 195.5 0.2 3.5e-58 194.8 0.1 1.4 1 1 0 1 1 1 1 Ribosomal S17 Beta_helix PF13229.6 ADV21860.1 - 1.8e-16 60.4 0.1 3.6e-16 59.4 0.1 1.5 1 0 0 1 1 1 1 Right handed beta helix region NosD PF05048.13 ADV21860.1 - 0.0027 17.0 0.1 0.86 8.8 0.1 2.6 2 1 0 3 3 3 2 Periplasmic copper-binding protein (NosD) Phasin PF05597.11 ADV21860.1 - 0.014 15.4 0.7 0.63 10.1 0.0 2.5 2 0 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) Disaggr_assoc PF08480.10 ADV21860.1 - 0.028 14.3 2.4 0.052 13.4 1.5 1.9 1 1 1 2 2 2 0 Disaggregatase related DUF4200 PF13863.6 ADV21860.1 - 0.086 13.2 0.3 0.15 12.5 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) Casc1_N PF15927.5 ADV21860.1 - 0.73 9.5 4.7 0.54 9.9 3.2 1.5 2 0 0 2 2 2 0 Cancer susceptibility candidate 1 N-terminus TMF_DNA_bd PF12329.8 ADV21860.1 - 0.8 9.8 3.1 0.82 9.7 2.0 1.6 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Got1 PF04178.12 ADV21862.1 - 1.1e-16 61.3 13.0 1.3e-16 61.0 13.0 1.1 1 0 0 1 1 1 1 Got1/Sft2-like family NIF PF03031.18 ADV21863.1 - 6.5e-51 172.2 0.0 9.9e-51 171.6 0.0 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Prefoldin PF02996.17 ADV21863.1 - 0.0082 16.1 0.0 0.057 13.3 0.0 2.1 1 1 0 1 1 1 1 Prefoldin subunit REV PF00424.18 ADV21863.1 - 0.12 12.4 5.2 2.7 8.1 0.7 3.1 2 0 0 2 2 2 0 REV protein (anti-repression trans-activator protein) DUF3835 PF12927.7 ADV21863.1 - 0.19 12.6 15.7 0.45 11.4 0.3 4.3 4 1 0 4 4 4 0 Domain of unknown function (DUF3835) TMEM135_C_rich PF15982.5 ADV21864.1 - 1.2e-05 25.9 0.8 4.3e-05 24.1 0.8 1.9 1 1 0 1 1 1 1 N-terminal cysteine-rich region of Transmembrane protein 135 KH_1 PF00013.29 ADV21865.1 - 6.6e-36 122.0 9.6 7.9e-13 48.0 0.3 3.3 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 ADV21865.1 - 1.3e-06 28.1 6.4 0.1 12.5 0.2 3.3 3 0 0 3 3 3 3 KH domain KH_4 PF13083.6 ADV21865.1 - 5e-06 26.3 4.4 0.0033 17.2 0.1 2.9 3 0 0 3 3 3 2 KH domain KH_5 PF13184.6 ADV21865.1 - 0.13 12.4 5.5 26 5.0 0.0 3.4 3 0 0 3 3 3 0 NusA-like KH domain CaATP_NAI PF12515.8 ADV21866.1 - 0.088 12.4 0.3 0.18 11.4 0.3 1.5 1 0 0 1 1 1 0 Ca2+-ATPase N terminal autoinhibitory domain UPF0052 PF01933.18 ADV21867.1 - 2.1e-45 155.3 0.0 2.8e-45 154.8 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family UPF0052 Herpes_DNAp_acc PF04929.12 ADV21867.1 - 0.054 12.5 0.1 0.093 11.7 0.1 1.3 1 0 0 1 1 1 0 Herpes DNA replication accessory factor Brix PF04427.18 ADV21868.1 - 1e-40 139.9 0.4 1.5e-40 139.4 0.4 1.2 1 0 0 1 1 1 1 Brix domain Pex19 PF04614.12 ADV21869.1 - 9.4e-60 202.4 0.1 1.2e-59 202.0 0.1 1.1 1 0 0 1 1 1 1 Pex19 protein family Hormone_3 PF00159.18 ADV21869.1 - 0.047 13.8 0.5 0.047 13.8 0.5 2.3 2 0 0 2 2 2 0 Pancreatic hormone peptide Longin PF13774.6 ADV21870.1 - 1.9e-20 72.7 0.1 5.8e-20 71.1 0.1 1.8 1 1 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.21 ADV21870.1 - 4.5e-14 52.0 0.0 7.7e-14 51.3 0.0 1.4 1 0 0 1 1 1 1 Synaptobrevin DUF1115 PF06544.12 ADV21871.1 - 0.011 15.8 0.0 0.024 14.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1115) Tyr-DNA_phospho PF06087.12 ADV21872.1 - 1.5e-37 129.6 0.0 1.2e-30 106.8 0.1 2.2 2 0 0 2 2 2 2 Tyrosyl-DNA phosphodiesterase PLDc_2 PF13091.6 ADV21872.1 - 0.012 15.5 0.1 0.12 12.2 0.0 2.3 2 0 0 2 2 2 0 PLD-like domain UIM PF02809.20 ADV21872.1 - 0.97 9.5 12.4 0.52 10.3 1.9 2.6 2 0 0 2 2 2 0 Ubiquitin interaction motif LRR_6 PF13516.6 ADV21873.1 - 2.2e-13 49.1 9.7 0.0011 18.8 0.3 8.5 9 0 0 9 9 9 2 Leucine Rich repeat LRR_4 PF12799.7 ADV21873.1 - 5.3e-09 36.2 12.9 0.02 15.3 0.2 6.8 4 2 3 7 7 7 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ADV21873.1 - 0.0036 17.6 10.1 2.9 8.8 2.0 6.3 6 2 0 6 6 6 1 Leucine Rich Repeat LRR_8 PF13855.6 ADV21873.1 - 0.0061 16.3 11.0 0.67 9.8 1.2 5.2 3 1 1 4 4 4 2 Leucine rich repeat CDC45 PF02724.14 ADV21873.1 - 0.25 9.6 12.4 0.36 9.1 12.4 1.1 1 0 0 1 1 1 0 CDC45-like protein PTPRCAP PF15713.5 ADV21873.1 - 3.5 7.9 21.0 7.5 6.8 21.0 1.4 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Nop14 PF04147.12 ADV21873.1 - 4.1 5.5 15.7 5.9 5.0 15.7 1.2 1 0 0 1 1 1 0 Nop14-like family CobT PF06213.12 ADV21873.1 - 9 5.6 17.3 13 5.0 17.3 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Nsp1_C PF05064.13 ADV21874.1 - 2.8e-36 123.8 1.4 2.8e-36 123.8 1.4 1.9 2 0 0 2 2 2 1 Nsp1-like C-terminal region Nucleoporin_FG PF13634.6 ADV21874.1 - 1.8e-09 38.3 164.3 0.00012 22.8 37.4 7.9 1 1 2 3 3 1 1 Nucleoporin FG repeat region AAA_13 PF13166.6 ADV21874.1 - 0.0017 17.1 1.7 0.0023 16.7 1.7 1.2 1 0 0 1 1 1 1 AAA domain LTXXQ PF07813.12 ADV21874.1 - 0.032 14.9 5.0 0.068 13.9 5.0 1.6 1 0 0 1 1 1 0 LTXXQ motif family protein TACC_C PF05010.14 ADV21874.1 - 0.11 12.3 6.5 0.23 11.2 6.5 1.4 1 1 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal NPV_P10 PF05531.12 ADV21874.1 - 0.12 12.9 5.3 5.2 7.6 0.4 2.9 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF724 PF05266.14 ADV21874.1 - 0.14 12.0 3.0 0.25 11.1 3.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Sec34 PF04136.15 ADV21874.1 - 0.15 11.9 2.6 0.62 9.9 0.2 2.1 2 0 0 2 2 2 0 Sec34-like family BLOC1_2 PF10046.9 ADV21874.1 - 0.16 12.3 7.6 41 4.6 4.9 3.4 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Synaptonemal_3 PF15191.6 ADV21874.1 - 0.17 11.7 0.3 0.44 10.4 0.3 1.6 1 0 0 1 1 1 0 Synaptonemal complex central element protein 3 CHAD PF05235.14 ADV21874.1 - 0.17 11.8 2.8 0.26 11.2 2.8 1.2 1 0 0 1 1 1 0 CHAD domain GAS PF13851.6 ADV21874.1 - 0.37 10.1 7.0 0.57 9.5 7.0 1.3 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Fib_alpha PF08702.10 ADV21874.1 - 0.47 10.6 1.6 5.9 7.1 0.0 2.2 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family BAR_3 PF16746.5 ADV21874.1 - 0.98 9.1 4.9 2.8 7.6 0.3 2.1 1 1 0 2 2 2 0 BAR domain of APPL family SlyX PF04102.12 ADV21874.1 - 1.7 9.3 6.3 18 6.0 0.2 3.5 3 1 0 3 3 3 0 SlyX ERM PF00769.19 ADV21874.1 - 2.2 8.1 9.7 3.5 7.4 9.7 1.2 1 0 0 1 1 1 0 Ezrin/radixin/moesin family DUF1664 PF07889.12 ADV21874.1 - 2.7 8.1 4.2 9.7 6.3 0.6 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) CBFD_NFYB_HMF PF00808.23 ADV21875.1 - 1.4e-15 57.3 0.5 2.6e-15 56.4 0.5 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Neurexophilin PF06312.12 ADV21875.1 - 0.076 12.5 0.4 0.098 12.1 0.4 1.3 1 1 0 1 1 1 0 Neurexophilin PCMT PF01135.19 ADV21875.1 - 0.14 11.9 0.1 0.18 11.5 0.1 1.1 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CBFB_NFYA PF02045.15 ADV21876.1 - 8.9e-27 93.5 6.7 2.2e-26 92.2 6.7 1.7 1 0 0 1 1 1 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B NIF PF03031.18 ADV21877.1 - 5.8e-25 87.9 0.0 7.7e-25 87.5 0.0 1.1 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase ubiquitin PF00240.23 ADV21877.1 - 0.0046 16.7 0.0 0.0099 15.6 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin family OSCP PF00213.18 ADV21878.1 - 1.2e-41 142.7 0.9 1.2e-41 142.7 0.9 1.4 2 0 0 2 2 2 1 ATP synthase delta (OSCP) subunit DSPc PF00782.20 ADV21879.1 - 3.9e-19 68.8 0.0 5.7e-18 65.0 0.0 2.3 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ADV21879.1 - 0.0066 16.0 0.0 0.012 15.2 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DUF3403 PF11883.8 ADV21879.1 - 0.31 11.2 5.0 2.9 8.1 0.0 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF3403) DUF1509 PF07420.11 ADV21880.1 - 1 8.2 7.0 0.076 12.0 1.7 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1509) PRP38 PF03371.15 ADV21881.1 - 2.2e-58 197.0 0.4 2.5e-58 196.8 0.4 1.0 1 0 0 1 1 1 1 PRP38 family LSM PF01423.22 ADV21882.1 - 4.8e-21 74.2 0.0 5.3e-21 74.1 0.0 1.0 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 ADV21882.1 - 0.016 15.3 0.0 0.02 15.0 0.0 1.1 1 0 0 1 1 1 0 Ataxin 2 SM domain E1-E2_ATPase PF00122.20 ADV21883.1 - 1.4e-29 102.9 0.0 3.2e-29 101.7 0.0 1.6 1 0 0 1 1 1 1 E1-E2 ATPase P5-ATPase PF12409.8 ADV21883.1 - 9.4e-23 80.7 0.0 2.3e-22 79.4 0.0 1.7 1 0 0 1 1 1 1 P5-type ATPase cation transporter Hydrolase PF00702.26 ADV21883.1 - 1.9e-17 64.3 0.1 8.1e-09 36.1 0.0 3.2 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_C PF00689.21 ADV21883.1 - 5.7e-05 22.9 8.1 0.00015 21.5 8.1 1.7 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 ADV21883.1 - 0.00091 19.3 0.0 0.0024 17.9 0.0 1.7 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 ADV21883.1 - 0.11 12.2 0.0 0.35 10.6 0.0 1.8 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase PufQ PF05398.11 ADV21884.1 - 0.012 15.7 0.0 0.023 14.8 0.0 1.4 1 0 0 1 1 1 0 PufQ cytochrome subunit Rsd_AlgQ PF04353.13 ADV21884.1 - 0.077 12.9 0.2 0.13 12.2 0.2 1.3 1 0 0 1 1 1 0 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ Syndecan PF01034.20 ADV21884.1 - 0.19 11.7 0.1 0.42 10.6 0.1 1.5 1 0 0 1 1 1 0 Syndecan domain ACBP PF00887.19 ADV21885.1 - 1.4e-25 89.3 0.1 4.1e-25 87.8 0.0 1.9 2 0 0 2 2 2 1 Acyl CoA binding protein RNA_pol_Rpb1_5 PF04998.17 ADV21886.1 - 7.1e-88 294.5 0.0 1.8e-87 293.1 0.0 1.7 1 1 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 ADV21886.1 - 4e-67 225.6 0.2 1.1e-66 224.2 0.2 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 ADV21886.1 - 1.3e-32 112.9 0.0 2.9e-32 111.8 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_1 PF04997.12 ADV21886.1 - 5.3e-31 108.1 0.6 9.2e-24 84.3 0.0 4.4 3 1 0 3 3 3 2 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_4 PF05000.17 ADV21886.1 - 1.2e-22 79.9 0.0 4.5e-22 78.0 0.0 2.0 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 DUF2828 PF11443.8 ADV21887.1 - 3.5e-141 471.4 0.0 5.5e-76 256.0 0.0 2.1 1 1 1 2 2 2 2 Domain of unknown function (DUF2828) Fes1 PF08609.10 ADV21888.1 - 4e-28 98.1 3.7 1.8e-27 96.0 3.7 2.1 1 1 0 1 1 1 1 Nucleotide exchange factor Fes1 HEAT PF02985.22 ADV21888.1 - 0.0049 17.0 0.0 41 4.8 0.0 3.5 3 0 0 3 3 3 0 HEAT repeat HEAT_2 PF13646.6 ADV21888.1 - 0.0079 16.6 0.0 0.035 14.5 0.0 2.1 1 1 1 2 2 2 1 HEAT repeats Arm PF00514.23 ADV21888.1 - 0.068 13.2 0.0 0.2 11.8 0.0 1.8 1 0 0 1 1 1 0 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 ADV21888.1 - 0.074 13.6 0.0 6.3 7.4 0.0 2.9 3 0 0 3 3 3 0 HEAT-like repeat BAR PF03114.18 ADV21889.1 - 3.9e-41 141.3 0.1 5.4e-41 140.8 0.1 1.2 1 0 0 1 1 1 1 BAR domain SH3_1 PF00018.28 ADV21889.1 - 4.9e-14 51.7 0.1 9.4e-14 50.8 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ADV21889.1 - 3e-11 43.0 0.1 8.1e-11 41.6 0.1 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 ADV21889.1 - 3.1e-07 30.0 0.0 5.9e-07 29.1 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Ribosomal_S27 PF01599.19 ADV21890.1 - 1e-25 89.6 0.5 1e-25 89.6 0.5 1.8 2 0 0 2 2 2 1 Ribosomal protein S27a ubiquitin PF00240.23 ADV21890.1 - 5.9e-24 83.6 0.0 1.1e-23 82.8 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ADV21890.1 - 1.7e-12 47.0 0.0 3e-12 46.2 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 ADV21890.1 - 0.0087 16.5 0.0 0.038 14.4 0.0 2.0 1 1 0 1 1 1 1 Ubiquitin-like domain IBR PF01485.21 ADV21890.1 - 0.023 14.9 0.3 0.038 14.2 0.3 1.4 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain RNA_pol_A_bac PF01000.26 ADV21891.1 - 5.7e-25 87.9 0.0 9.7e-25 87.1 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 ADV21891.1 - 6.4e-22 76.8 0.0 9.4e-22 76.2 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain adh_short PF00106.25 ADV21892.1 - 1.5e-05 24.6 0.0 1 8.8 0.0 3.5 3 1 0 3 3 3 3 short chain dehydrogenase ThrE PF06738.12 ADV21893.1 - 3.8e-55 186.9 10.7 3.8e-55 186.9 10.7 2.3 2 0 0 2 2 2 1 Putative threonine/serine exporter ThrE_2 PF12821.7 ADV21893.1 - 5e-10 39.6 1.5 5e-10 39.6 1.5 2.8 2 1 0 2 2 2 1 Threonine/Serine exporter, ThrE LAG1-DNAbind PF09271.11 ADV21894.1 - 1.3e-42 146.0 0.0 2.5e-42 145.1 0.0 1.5 1 0 0 1 1 1 1 LAG1, DNA binding BTD PF09270.10 ADV21894.1 - 3.3e-15 56.6 0.0 1.1e-14 54.9 0.0 1.8 1 1 0 1 1 1 1 Beta-trefoil DNA-binding domain DUF4670 PF15709.5 ADV21895.1 - 0.0039 16.6 7.7 0.0043 16.4 7.7 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4670) Alb1 PF09135.11 ADV21895.1 - 0.011 16.6 12.6 0.012 16.5 12.6 1.0 1 0 0 1 1 1 0 Alb1 DUF4407 PF14362.6 ADV21895.1 - 0.62 9.4 4.2 0.63 9.3 4.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Peptidase_M18 PF02127.15 ADV21896.1 - 2.2e-150 501.2 0.0 7.7e-150 499.4 0.0 1.7 1 1 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.14 ADV21896.1 - 7.7e-05 21.9 0.1 0.0017 17.4 0.1 2.1 2 0 0 2 2 2 2 M42 glutamyl aminopeptidase SMC_N PF02463.19 ADV21897.1 - 5.2e-63 212.4 29.2 9.3e-63 211.6 29.2 1.5 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 ADV21897.1 - 3.3e-29 101.6 0.0 1e-28 100.0 0.0 1.9 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.6 ADV21897.1 - 1.5e-18 68.1 16.6 1.5e-18 68.1 16.6 6.5 2 2 3 5 5 5 1 AAA domain AAA_21 PF13304.6 ADV21897.1 - 2.9e-15 56.9 6.0 5.6e-08 32.9 0.2 3.1 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 ADV21897.1 - 2.1e-11 44.2 48.8 3.1e-09 37.0 14.5 4.4 2 2 1 3 3 3 2 AAA ATPase domain AAA_29 PF13555.6 ADV21897.1 - 0.014 15.1 0.0 0.03 14.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Nif11 PF07862.11 ADV21897.1 - 2.7 8.4 6.8 8.3 6.8 1.5 4.3 3 0 0 3 3 3 0 Nif11 domain DAGK_cat PF00781.24 ADV21898.1 - 1.5e-25 89.2 0.3 1.4e-24 86.1 0.2 2.3 2 0 0 2 2 2 1 Diacylglycerol kinase catalytic domain SNF2_N PF00176.23 ADV21899.1 - 4.2e-53 180.3 0.0 7.2e-53 179.5 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Rad54_N PF08658.10 ADV21899.1 - 9.6e-45 152.9 0.0 1.7e-44 152.1 0.0 1.4 1 0 0 1 1 1 1 Rad54 N terminal Helicase_C PF00271.31 ADV21899.1 - 2e-16 60.3 0.0 4.6e-16 59.1 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 ADV21899.1 - 3e-06 26.6 0.2 1.9e-05 24.0 0.0 2.3 2 1 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.15 ADV21899.1 - 1.8e-05 24.8 0.0 4.3e-05 23.6 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 ADV21899.1 - 0.0024 17.7 0.2 0.27 11.0 0.0 2.8 3 0 0 3 3 3 1 DEAD/DEAH box helicase ERCC3_RAD25_C PF16203.5 ADV21899.1 - 0.0028 16.9 0.0 0.0047 16.2 0.0 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase AAA_22 PF13401.6 ADV21899.1 - 0.0069 16.7 0.0 1.7 9.0 0.0 3.3 2 1 0 2 2 2 1 AAA domain Slu7 PF11708.8 ADV21900.1 - 3.1e-108 361.6 22.9 3.1e-108 361.6 22.9 2.3 2 0 0 2 2 2 1 Pre-mRNA splicing Prp18-interacting factor DUF1028 PF06267.12 ADV21900.1 - 0.033 14.0 0.2 0.077 12.8 0.2 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF1028) zf-CCHC_4 PF14392.6 ADV21900.1 - 0.075 12.8 0.6 0.15 11.9 0.6 1.4 1 0 0 1 1 1 0 Zinc knuckle Vfa1 PF08432.10 ADV21900.1 - 1.8 8.9 23.9 1.9 8.8 6.7 2.7 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 PfkB PF00294.24 ADV21901.1 - 5.8e-14 52.1 0.2 2.1e-13 50.2 0.2 1.7 1 1 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 ADV21901.1 - 0.049 13.0 0.0 0.084 12.2 0.0 1.3 1 0 0 1 1 1 0 Phosphomethylpyrimidine kinase FGGY_N PF00370.21 ADV21902.1 - 2.7e-65 220.3 0.2 1.6e-34 119.6 0.2 2.2 2 0 0 2 2 2 2 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 ADV21902.1 - 1.1e-60 204.7 1.3 1.7e-60 204.2 1.3 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Ribosomal_S6e PF01092.19 ADV21903.1 - 3.2e-54 182.2 1.3 3.3e-54 182.2 0.2 1.6 2 0 0 2 2 2 1 Ribosomal protein S6e FA_desaturase PF00487.24 ADV21904.1 - 1.2e-22 81.0 24.7 3.3e-22 79.5 24.7 1.6 1 1 0 1 1 1 1 Fatty acid desaturase DUF3474 PF11960.8 ADV21904.1 - 5.7e-05 23.3 0.0 0.0001 22.5 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3474) ARPC4 PF05856.12 ADV21905.1 - 4.2e-79 264.0 2.2 4.7e-79 263.8 2.2 1.0 1 0 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) Nbl1_Borealin_N PF10444.9 ADV21906.1 - 3.8e-15 55.3 0.7 8.1e-15 54.2 0.7 1.6 1 0 0 1 1 1 1 Nbl1 / Borealin N terminal zf-Nse PF11789.8 ADV21907.1 - 5.5e-17 61.3 0.4 1.1e-16 60.4 0.4 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.6 ADV21907.1 - 2.5e-07 30.6 0.6 5.8e-07 29.4 0.6 1.7 1 0 0 1 1 1 1 RING-type zinc-finger U-box PF04564.15 ADV21907.1 - 1.7e-06 28.1 0.1 4.8e-06 26.7 0.0 1.8 2 0 0 2 2 2 1 U-box domain zf-C3HC4_2 PF13923.6 ADV21907.1 - 0.0056 16.5 1.8 0.018 14.8 1.8 1.9 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Pox_G9-A16 PF03003.16 ADV21907.1 - 0.027 14.2 0.9 0.049 13.3 0.4 1.7 2 0 0 2 2 2 0 Pox virus entry-fusion-complex G9/A16 zf-C3HC4 PF00097.25 ADV21907.1 - 0.067 13.1 0.8 0.15 12.0 0.8 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) IBR PF01485.21 ADV21907.1 - 1.2 9.4 5.4 6.7 7.0 0.1 2.5 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain zf-C2HE PF16278.5 ADV21907.1 - 1.8 9.0 3.8 8.6 6.9 0.1 3.3 3 0 0 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger DEAD PF00270.29 ADV21908.1 - 2.9e-46 157.4 0.0 8.1e-45 152.7 0.0 2.4 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ADV21908.1 - 1.2e-32 112.6 0.0 9.9e-30 103.2 0.0 2.7 3 0 0 3 3 3 2 Helicase conserved C-terminal domain ResIII PF04851.15 ADV21908.1 - 0.00022 21.3 0.0 0.0025 17.8 0.0 2.7 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit peroxidase PF00141.23 ADV21910.1 - 4.9e-46 157.3 0.0 8.1e-46 156.6 0.0 1.3 1 0 0 1 1 1 1 Peroxidase Casc1 PF12366.8 ADV21910.1 - 0.16 11.5 0.1 0.23 10.9 0.1 1.2 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 Aconitase PF00330.20 ADV21911.1 - 7.1e-152 506.6 0.0 8.9e-152 506.3 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 ADV21911.1 - 1.3e-44 151.7 0.0 2.2e-44 151.0 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain MRP-S25 PF13741.6 ADV21912.1 - 1.4e-43 149.1 0.0 2e-43 148.6 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein S25 MRP-S23 PF10484.9 ADV21912.1 - 0.00066 19.9 1.2 0.47 10.7 0.1 2.5 2 1 0 2 2 2 2 Mitochondrial ribosomal protein S23 WD40 PF00400.32 ADV21913.1 - 4.4e-60 198.2 11.2 1.4e-11 44.7 0.3 8.3 7 2 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV21913.1 - 6.2e-21 74.5 1.6 5.6e-07 29.8 0.1 5.5 2 2 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ADV21913.1 - 8.4e-10 37.9 9.1 0.024 13.3 1.5 5.3 4 1 2 6 6 6 3 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ADV21913.1 - 1.6e-08 33.9 0.3 0.45 9.4 0.0 4.7 2 1 2 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 ADV21913.1 - 2.3e-06 26.6 0.3 0.23 10.1 0.3 4.0 2 1 1 4 4 4 3 Nup133 N terminal like Cytochrom_D1 PF02239.16 ADV21913.1 - 0.058 11.9 0.1 2.8 6.4 0.0 2.3 2 0 0 2 2 2 0 Cytochrome D1 heme domain bZIP_2 PF07716.15 ADV21913.1 - 0.18 11.9 0.0 0.3 11.2 0.0 1.3 1 0 0 1 1 1 0 Basic region leucine zipper NYD-SP28_assoc PF14775.6 ADV21913.1 - 2.7 8.2 7.7 94 3.2 0.0 5.0 6 0 0 6 6 6 0 Sperm tail C-terminal domain SNase PF00565.17 ADV21914.1 - 6.5e-19 68.4 0.0 9.1e-19 67.9 0.0 1.2 1 0 0 1 1 1 1 Staphylococcal nuclease homologue RRM_1 PF00076.22 ADV21915.1 - 4.9e-10 39.1 0.0 2.3e-09 36.9 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2406 PF10295.9 ADV21916.1 - 1.4e-06 28.9 0.0 6.9e-06 26.7 0.0 2.2 1 0 0 1 1 1 1 Uncharacterised protein (DUF2406) PseudoU_synth_2 PF00849.22 ADV21917.1 - 1.7e-30 106.2 0.0 2.5e-30 105.7 0.0 1.2 1 0 0 1 1 1 1 RNA pseudouridylate synthase Peptidase_C2 PF00648.21 ADV21918.1 - 0.0015 17.6 0.0 0.0016 17.5 0.0 1.1 1 0 0 1 1 1 1 Calpain family cysteine protease NatB_MDM20 PF09797.9 ADV21919.1 - 1e-40 139.9 2.7 1.8e-40 139.1 1.4 1.9 2 0 0 2 2 2 1 N-acetyltransferase B complex (NatB) non catalytic subunit TPR_14 PF13428.6 ADV21919.1 - 0.00075 20.1 0.8 17 6.6 0.0 4.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 ADV21919.1 - 0.02 15.5 1.1 21 6.0 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat Glucosamine_iso PF01182.20 ADV21920.1 - 7.5e-60 202.6 0.1 1.3e-59 201.8 0.0 1.4 2 0 0 2 2 2 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Wzy_C_2 PF11846.8 ADV21920.1 - 0.071 13.0 0.1 0.19 11.6 0.1 1.6 2 0 0 2 2 2 0 Virulence factor membrane-bound polymerase, C-terminal V-ATPase_G PF03179.15 ADV21920.1 - 0.18 12.4 5.6 0.4 11.2 5.6 1.5 1 0 0 1 1 1 0 Vacuolar (H+)-ATPase G subunit DWNN PF08783.11 ADV21921.1 - 3.8e-27 94.4 0.0 6.4e-27 93.6 0.0 1.4 1 0 0 1 1 1 1 DWNN domain zf-CCHC_2 PF13696.6 ADV21921.1 - 1.3e-08 34.5 6.9 2.6e-08 33.5 6.9 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.23 ADV21921.1 - 1.9e-05 24.5 2.6 4.7e-05 23.3 2.6 1.7 1 0 0 1 1 1 1 Zinc knuckle zf-C3HC4_3 PF13920.6 ADV21921.1 - 0.00013 21.7 8.9 0.00013 21.7 8.9 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ADV21921.1 - 0.0021 17.9 13.9 0.0021 17.9 13.9 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-CCHC_3 PF13917.6 ADV21921.1 - 0.0045 16.9 0.1 0.0045 16.9 0.1 1.8 2 0 0 2 2 2 1 Zinc knuckle zf-C3HC4 PF00097.25 ADV21921.1 - 1.8 8.5 12.9 3.8 7.5 12.9 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Evr1_Alr PF04777.13 ADV21922.1 - 4.2e-27 94.5 0.3 7.3e-27 93.8 0.3 1.4 1 0 0 1 1 1 1 Erv1 / Alr family SAP PF02037.27 ADV21923.1 - 5.9e-10 38.7 0.5 1.3e-09 37.5 0.5 1.6 1 0 0 1 1 1 1 SAP domain Kelch_4 PF13418.6 ADV21924.1 - 2.3e-19 69.2 1.6 2.7e-06 27.3 0.1 4.9 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_5 PF13854.6 ADV21924.1 - 1.3e-12 47.4 3.8 0.0016 18.4 0.1 4.6 4 0 0 4 4 4 3 Kelch motif Kelch_3 PF13415.6 ADV21924.1 - 1.5e-11 44.3 11.8 0.013 15.8 0.1 6.1 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_6 PF13964.6 ADV21924.1 - 1.5e-08 34.6 1.7 0.00022 21.4 0.0 3.9 3 1 1 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ADV21924.1 - 5.3e-08 32.5 0.7 0.033 14.2 0.0 3.9 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ADV21924.1 - 2.7e-05 23.7 0.1 0.0015 18.0 0.0 3.2 3 0 0 3 3 3 1 Kelch motif Rax2 PF12768.7 ADV21926.1 - 6.1e-39 133.7 0.7 6.1e-37 127.2 0.2 3.7 3 0 0 3 3 3 1 Cortical protein marker for cell polarity SH3_1 PF00018.28 ADV21926.1 - 7.8e-10 38.2 0.0 1.7e-09 37.1 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ADV21926.1 - 3.4e-06 26.8 0.1 8.8e-06 25.5 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain Kelch_6 PF13964.6 ADV21926.1 - 0.03 14.6 7.5 10 6.6 0.1 6.5 7 0 0 7 7 7 0 Kelch motif HisKA_4TM PF16926.5 ADV21926.1 - 0.074 12.6 0.7 0.26 10.8 0.1 2.2 2 0 0 2 2 2 0 Archaeal 4TM region of histidine kinase SKG6 PF08693.10 ADV21926.1 - 1.2 8.6 5.3 3.2 7.2 5.3 1.8 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Ebp2 PF05890.12 ADV21927.1 - 7.8e-84 281.4 6.7 7.8e-84 281.4 6.7 2.1 2 1 0 2 2 2 1 Eukaryotic rRNA processing protein EBP2 Polysacc_deac_1 PF01522.21 ADV21929.1 - 2.3e-24 85.7 0.0 4e-24 84.9 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase LRR_4 PF12799.7 ADV21930.1 - 1.5e-28 98.3 54.7 5.2e-09 36.2 3.3 6.7 2 2 6 8 8 8 8 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ADV21930.1 - 1.2e-20 73.0 30.7 5.1e-07 29.4 7.4 5.7 3 2 2 5 5 5 5 Leucine rich repeat LRR_9 PF14580.6 ADV21930.1 - 5.3e-20 71.6 9.0 6.2e-08 32.3 0.1 3.3 1 1 2 3 3 3 3 Leucine-rich repeat LRR_6 PF13516.6 ADV21930.1 - 1.6e-05 24.6 19.7 1.3 9.3 0.1 7.7 8 0 0 8 8 8 4 Leucine Rich repeat LRR_1 PF00560.33 ADV21930.1 - 0.02 15.3 33.1 2.6 8.9 0.5 9.4 9 2 0 9 9 9 0 Leucine Rich Repeat Vir_act_alpha_C PF10400.9 ADV21930.1 - 0.042 14.5 0.1 0.11 13.1 0.1 1.7 1 0 0 1 1 1 0 Virulence activator alpha C-term PPR_2 PF13041.6 ADV21931.1 - 0.00027 21.1 0.0 0.0066 16.6 0.0 2.7 1 1 1 2 2 2 2 PPR repeat family PPR_long PF17177.4 ADV21931.1 - 0.00049 19.5 0.0 0.0009 18.7 0.0 1.4 1 0 0 1 1 1 1 Pentacotripeptide-repeat region of PRORP PPR PF01535.20 ADV21931.1 - 0.0066 16.6 0.2 0.38 11.1 0.0 3.6 3 0 0 3 3 3 1 PPR repeat MyTH4 PF00784.17 ADV21931.1 - 0.16 12.5 0.3 18 5.9 0.0 2.5 2 0 0 2 2 2 0 MyTH4 domain Vac14_Fig4_bd PF11916.8 ADV21933.1 - 2.3e-78 262.0 6.9 2.3e-78 262.0 6.9 1.7 2 0 0 2 2 2 1 Vacuolar protein 14 C-terminal Fig4p binding Vac14_Fab1_bd PF12755.7 ADV21933.1 - 8.5e-45 151.3 0.0 1.9e-40 137.4 0.0 4.3 4 0 0 4 4 4 1 Vacuolar 14 Fab1-binding region HEAT PF02985.22 ADV21933.1 - 1.2e-09 37.6 1.5 0.0082 16.3 0.0 6.1 6 0 0 6 6 6 2 HEAT repeat HEAT_EZ PF13513.6 ADV21933.1 - 8.4e-07 29.4 0.5 0.0064 17.0 0.0 4.9 6 0 0 6 6 6 1 HEAT-like repeat HEAT_2 PF13646.6 ADV21933.1 - 1.9e-06 28.1 0.5 1.5 9.2 0.0 4.7 5 0 0 5 5 5 2 HEAT repeats Cnd1 PF12717.7 ADV21933.1 - 2.9e-06 27.4 0.8 0.05 13.6 0.2 3.4 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 DUF3385 PF11865.8 ADV21933.1 - 0.012 15.5 0.1 11 5.8 0.0 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF3385) DUF3437 PF11919.8 ADV21933.1 - 0.017 15.1 0.6 2.5 8.1 0.0 4.3 4 0 0 4 4 4 0 Domain of unknown function (DUF3437) Arm PF00514.23 ADV21933.1 - 0.02 14.9 0.0 13 6.0 0.0 3.4 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat DUF5071 PF16804.5 ADV21933.1 - 0.13 12.5 0.6 11 6.3 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF5071) RasGEF_N_2 PF14663.6 ADV21933.1 - 0.38 11.2 6.5 12 6.4 0.0 4.0 4 0 0 4 4 4 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain SbcD_C PF12320.8 ADV21934.1 - 0.26 11.6 4.7 0.51 10.7 3.4 2.1 2 0 0 2 2 2 0 Type 5 capsule protein repressor C-terminal domain TERB2 PF15101.6 ADV21934.1 - 5.6 7.0 14.8 13 5.7 8.6 2.5 2 0 0 2 2 2 0 Telomere-associated protein TERB2 HECT PF00632.25 ADV21935.1 - 6.8e-76 255.7 0.0 9.7e-76 255.2 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Arm PF00514.23 ADV21935.1 - 2.9e-05 23.9 3.1 0.043 13.9 0.0 4.6 4 1 1 5 5 5 2 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 ADV21935.1 - 0.00053 20.3 0.2 0.31 11.5 0.0 4.0 2 1 1 3 3 3 1 HEAT repeats UIM PF02809.20 ADV21935.1 - 0.22 11.5 3.2 1.3 9.1 3.2 2.5 1 0 0 1 1 1 0 Ubiquitin interaction motif Rhodanese PF00581.20 ADV21936.1 - 1.1e-17 64.5 0.0 3.5e-11 43.6 0.0 2.3 2 0 0 2 2 2 2 Rhodanese-like domain zf-Tim10_DDP PF02953.15 ADV21937.1 - 2.3e-19 68.8 0.3 2.8e-19 68.5 0.3 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger FAM196 PF15265.6 ADV21938.1 - 2.1 7.8 17.2 2.7 7.4 17.2 1.2 1 0 0 1 1 1 0 FAM196 family Fungal_trans PF04082.18 ADV21939.1 - 2e-19 69.7 0.0 3.1e-19 69.0 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Aldo_ket_red PF00248.21 ADV21940.1 - 2.7e-50 171.2 0.0 9.1e-49 166.2 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family RHH_1 PF01402.21 ADV21940.1 - 0.0021 17.9 0.6 0.024 14.6 0.1 2.5 3 0 0 3 3 3 1 Ribbon-helix-helix protein, copG family DUF3251 PF11622.8 ADV21940.1 - 0.095 12.3 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3251) Tox-WTIP PF15654.6 ADV21940.1 - 1.1 9.7 6.7 23 5.5 0.4 3.3 2 1 1 3 3 3 0 Toxin with a conserved tryptophan and TIP tripeptide motif CUE PF02845.16 ADV21941.1 - 0.0058 16.3 0.2 0.028 14.1 0.1 2.2 2 0 0 2 2 2 1 CUE domain Smr PF01713.21 ADV21941.1 - 0.22 11.9 0.9 0.68 10.3 0.0 2.2 2 0 0 2 2 2 0 Smr domain Pep1_7 PF17232.2 ADV21941.1 - 8 7.0 7.7 1.2 9.7 0.0 3.1 3 0 0 3 3 3 0 Elicitor peptide 1-7 PHD PF00628.29 ADV21942.1 - 2.7e-10 40.0 10.5 5e-10 39.1 10.5 1.5 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 ADV21942.1 - 0.0073 15.8 3.6 0.013 15.0 3.6 1.4 1 0 0 1 1 1 1 PHD-finger Mal_decarbox_Al PF16957.5 ADV21942.1 - 0.047 12.0 0.5 0.072 11.4 0.5 1.1 1 0 0 1 1 1 0 Malonate decarboxylase, alpha subunit, transporter SH3_9 PF14604.6 ADV21943.1 - 1e-06 28.5 0.0 2e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 ADV21943.1 - 5.8e-06 25.9 0.0 1.1e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ADV21943.1 - 8.6e-05 22.1 0.0 0.00017 21.1 0.0 1.5 1 0 0 1 1 1 1 SH3 domain WD40 PF00400.32 ADV21944.1 - 2.8e-39 132.4 17.7 1.6e-07 31.9 0.0 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV21944.1 - 8.5e-16 58.0 0.1 0.0012 19.1 0.1 5.2 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ADV21944.1 - 0.0012 18.2 0.0 1.4 8.2 0.0 3.2 1 1 2 3 3 3 2 WD40-like domain eIF2A PF08662.11 ADV21944.1 - 0.011 15.6 0.0 7.6 6.4 0.0 2.6 2 1 1 3 3 3 0 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ADV21944.1 - 0.032 13.2 0.3 13 4.7 0.1 3.4 2 1 2 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein VTC PF09359.10 ADV21945.1 - 1.3e-97 326.6 0.0 2.1e-97 325.8 0.0 1.4 1 0 0 1 1 1 1 VTC domain SPX PF03105.19 ADV21945.1 - 4.7e-19 69.6 25.0 9.4e-08 32.4 0.3 4.3 3 1 0 3 3 3 3 SPX domain DUF202 PF02656.15 ADV21945.1 - 4.1e-10 40.0 2.7 4.8e-10 39.7 1.4 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF202) D123 PF07065.14 ADV21945.1 - 0.024 13.8 0.2 0.066 12.4 0.2 1.8 1 0 0 1 1 1 0 D123 DUF5561 PF17716.1 ADV21945.1 - 0.058 12.7 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5561) ABC_tran_CTD PF16326.5 ADV21945.1 - 0.086 13.1 1.0 12 6.2 0.2 2.9 2 0 0 2 2 2 0 ABC transporter C-terminal domain DUF966 PF06136.13 ADV21945.1 - 0.52 10.0 6.2 1.1 9.0 6.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Snf7 PF03357.21 ADV21946.1 - 4.4e-20 72.0 15.9 6e-17 61.8 2.9 2.0 1 1 1 2 2 2 2 Snf7 WASH_WAHD PF11945.8 ADV21946.1 - 0.0071 15.9 0.6 0.082 12.4 0.0 2.0 1 1 1 2 2 2 2 WAHD domain of WASH complex Lon_C PF05362.13 ADV21947.1 - 2e-66 223.4 0.2 3.2e-66 222.8 0.2 1.3 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain LON_substr_bdg PF02190.16 ADV21947.1 - 3.7e-30 105.4 0.7 6.3e-30 104.6 0.1 1.7 2 0 0 2 2 2 1 ATP-dependent protease La (LON) substrate-binding domain AAA PF00004.29 ADV21947.1 - 2.8e-21 76.3 0.1 2.7e-20 73.1 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ADV21947.1 - 1.1e-07 31.9 0.0 2.2e-07 31.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) ChlI PF13541.6 ADV21947.1 - 3e-07 30.3 0.1 8.6e-07 28.8 0.1 1.8 2 0 0 2 2 2 1 Subunit ChlI of Mg-chelatase AAA_PrkA PF08298.11 ADV21947.1 - 1.7e-05 23.9 0.0 3.1e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 PrkA AAA domain AAA_2 PF07724.14 ADV21947.1 - 2.9e-05 24.3 0.0 0.00012 22.2 0.0 2.0 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 ADV21947.1 - 0.00016 21.4 0.1 0.001 18.9 0.0 2.3 3 0 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 ADV21947.1 - 0.0009 19.8 0.0 0.008 16.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 ADV21947.1 - 0.0013 19.0 0.3 0.041 14.1 0.3 2.5 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ADV21947.1 - 0.0014 19.1 0.1 0.0061 17.0 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain AAA_14 PF13173.6 ADV21947.1 - 0.0059 16.6 0.0 0.017 15.2 0.0 1.8 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 ADV21947.1 - 0.011 15.6 0.4 0.15 11.9 0.0 2.4 2 0 0 2 2 2 0 RsgA GTPase RNA_helicase PF00910.22 ADV21947.1 - 0.024 15.0 0.0 0.055 13.9 0.0 1.7 1 0 0 1 1 1 0 RNA helicase SKI PF01202.22 ADV21947.1 - 0.031 14.4 0.1 0.064 13.4 0.1 1.5 1 0 0 1 1 1 0 Shikimate kinase Rad17 PF03215.15 ADV21947.1 - 0.041 13.8 0.1 0.23 11.4 0.0 2.1 2 0 0 2 2 2 0 Rad17 P-loop domain IstB_IS21 PF01695.17 ADV21947.1 - 0.08 12.7 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_30 PF13604.6 ADV21947.1 - 0.13 11.9 0.0 0.28 10.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 ADV21947.1 - 0.16 12.0 0.0 0.34 10.9 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF913 PF06025.12 ADV21947.1 - 0.72 8.8 4.0 0.21 10.5 0.1 1.8 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) ABC_tran PF00005.27 ADV21947.1 - 1.2 9.6 3.4 1.3 9.5 0.3 2.4 2 1 0 2 2 2 0 ABC transporter Acetyltransf_3 PF13302.7 ADV21948.1 - 6.7e-07 30.1 0.0 9.7e-07 29.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FHIPEP PF00771.20 ADV21949.1 - 0.077 11.5 0.0 0.22 9.9 0.0 1.6 2 0 0 2 2 2 0 FHIPEP family ZoocinA_TRD PF16775.5 ADV21949.1 - 0.12 12.5 0.0 0.25 11.5 0.0 1.4 1 0 0 1 1 1 0 Target recognition domain of lytic exoenzyme SAGA-Tad1 PF12767.7 ADV21949.1 - 1.1 9.0 9.9 16 5.1 9.9 2.4 1 1 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit DUF810 PF05664.11 ADV21949.1 - 1.2 7.6 3.4 1.9 6.9 3.4 1.2 1 0 0 1 1 1 0 Plant family of unknown function (DUF810) tRNA-synt_2 PF00152.20 ADV21950.1 - 6.5e-78 262.0 0.0 9e-78 261.5 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 ADV21950.1 - 5.5e-10 39.1 0.4 9.3e-10 38.4 0.4 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain W2 PF02020.18 ADV21951.1 - 5.5e-19 68.1 0.1 7.6e-18 64.4 0.0 2.7 3 0 0 3 3 3 1 eIF4-gamma/eIF5/eIF2-epsilon SapB_1 PF05184.15 ADV21951.1 - 0.25 11.4 0.5 0.72 9.9 0.5 1.8 1 0 0 1 1 1 0 Saposin-like type B, region 1 Isy1 PF06246.12 ADV21952.1 - 6.5e-89 297.9 4.8 1.1e-88 297.1 4.8 1.3 1 1 0 1 1 1 1 Isy1-like splicing family zf-CCHC PF00098.23 ADV21953.1 - 6.8e-35 117.6 42.3 1.8e-08 34.0 2.5 6.3 6 0 0 6 6 6 6 Zinc knuckle zf-CCHC_4 PF14392.6 ADV21953.1 - 8.7e-06 25.4 27.0 0.087 12.6 0.7 5.6 6 0 0 6 6 6 4 Zinc knuckle zf-CCHC_3 PF13917.6 ADV21953.1 - 0.00017 21.4 21.2 0.06 13.3 0.1 5.2 4 1 1 5 5 5 2 Zinc knuckle zf-CCHC_5 PF14787.6 ADV21953.1 - 0.0025 17.5 34.7 0.11 12.2 2.1 5.2 6 0 0 6 6 6 4 GAG-polyprotein viral zinc-finger Beta_helix PF13229.6 ADV21954.1 - 6.8e-10 39.0 22.1 2.2e-08 34.1 4.9 3.3 2 1 2 4 4 4 2 Right handed beta helix region NosD PF05048.13 ADV21954.1 - 0.00054 19.3 11.5 0.034 13.4 4.1 2.7 2 1 0 2 2 2 2 Periplasmic copper-binding protein (NosD) PhoLip_ATPase_C PF16212.5 ADV21956.1 - 1.4e-72 244.5 26.2 1.4e-72 244.5 26.2 2.2 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 ADV21956.1 - 8.8e-22 76.6 1.3 2.7e-21 75.0 1.3 1.8 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 ADV21956.1 - 1.6e-10 41.7 0.4 0.00016 22.0 0.2 3.3 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ADV21956.1 - 1e-09 38.3 0.0 2.2e-09 37.2 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 ADV21956.1 - 1.6e-05 24.5 1.6 3.6e-05 23.4 0.0 2.3 2 1 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.12 ADV21956.1 - 0.0035 17.1 0.1 0.028 14.1 0.1 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase UQ_con PF00179.26 ADV21957.1 - 4.7e-35 120.3 0.0 6.6e-35 119.8 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 ADV21957.1 - 0.11 12.2 0.0 0.15 11.8 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B DDE_1 PF03184.19 ADV21958.1 - 4.1e-19 68.9 0.0 8.8e-19 67.8 0.0 1.5 1 1 0 1 1 1 1 DDE superfamily endonuclease HTH_psq PF05225.16 ADV21958.1 - 9.9e-05 22.0 0.0 0.00037 20.2 0.0 2.0 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.16 ADV21958.1 - 0.0046 16.9 0.0 0.016 15.2 0.0 2.0 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DDE_3 PF13358.6 ADV21958.1 - 0.013 15.3 0.0 0.05 13.3 0.0 1.9 2 0 0 2 2 2 0 DDE superfamily endonuclease HTH_23 PF13384.6 ADV21958.1 - 0.035 13.9 0.0 0.16 11.8 0.0 2.2 1 0 0 1 1 1 0 Homeodomain-like domain HTH_7 PF02796.15 ADV21958.1 - 0.051 13.7 0.0 0.58 10.3 0.0 2.7 3 0 0 3 3 3 0 Helix-turn-helix domain of resolvase SMC_N PF02463.19 ADV21959.1 - 1.1e-28 100.2 0.0 4.3e-28 98.3 0.0 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 ADV21959.1 - 4.2e-10 40.4 70.8 3.5e-08 34.2 41.1 4.5 2 2 0 2 2 2 1 AAA domain AAA_15 PF13175.6 ADV21959.1 - 1.9e-08 34.4 16.3 1.9e-08 34.4 16.3 3.9 2 1 1 3 3 3 1 AAA ATPase domain AAA_29 PF13555.6 ADV21959.1 - 0.00068 19.3 0.0 0.0014 18.4 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.6 ADV21959.1 - 0.0013 18.6 0.9 0.0013 18.6 0.9 3.2 2 2 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system SMC_hinge PF06470.13 ADV21959.1 - 0.055 13.8 0.0 0.25 11.7 0.0 2.2 2 0 0 2 2 2 0 SMC proteins Flexible Hinge Domain AAA_16 PF13191.6 ADV21959.1 - 0.23 11.8 0.1 0.23 11.8 0.1 3.6 3 2 0 3 3 3 0 AAA ATPase domain PI_PP_I PF18363.1 ADV21959.1 - 1.4 9.1 14.1 4.8 7.4 0.3 4.5 4 0 0 4 4 4 0 Phosphoinositide phosphatase insertion domain Adaptin_N PF01602.20 ADV21960.1 - 7.7e-112 374.5 6.1 1.1e-111 374.1 6.1 1.2 1 0 0 1 1 1 1 Adaptin N terminal region COP-gamma_platf PF08752.10 ADV21960.1 - 8.6e-55 185.0 0.2 2e-54 183.9 0.2 1.6 1 0 0 1 1 1 1 Coatomer gamma subunit appendage platform subdomain Coatomer_g_Cpla PF16381.5 ADV21960.1 - 8e-34 116.2 0.0 3e-33 114.4 0.0 2.1 1 0 0 1 1 1 1 Coatomer subunit gamma-1 C-terminal appendage platform HEAT_2 PF13646.6 ADV21960.1 - 1.3e-19 70.3 0.4 1.4e-09 38.2 0.0 5.1 3 1 1 4 4 4 2 HEAT repeats Cnd1 PF12717.7 ADV21960.1 - 3.2e-09 37.0 10.5 0.00057 20.0 0.6 4.9 4 1 1 5 5 5 3 non-SMC mitotic condensation complex subunit 1 DUF3209 PF11483.8 ADV21960.1 - 0.0021 18.5 0.0 1.9 8.9 0.0 2.8 2 0 0 2 2 2 2 Protein of unknown function (DUF3209) HEAT PF02985.22 ADV21960.1 - 0.0034 17.5 4.2 3.1 8.3 0.0 5.6 6 0 0 6 6 6 1 HEAT repeat DUF3385 PF11865.8 ADV21960.1 - 0.048 13.6 4.1 13 5.7 0.2 4.2 2 1 2 4 4 4 0 Domain of unknown function (DUF3385) HEAT_PBS PF03130.16 ADV21960.1 - 0.15 12.8 1.2 67 4.6 0.0 5.0 6 0 0 6 6 5 0 PBS lyase HEAT-like repeat Arm PF00514.23 ADV21960.1 - 0.17 12.0 0.1 83 3.4 0.0 4.0 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat RTP1_C1 PF10363.9 ADV21960.1 - 0.2 11.8 2.1 1.7 8.8 0.2 3.2 2 1 1 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 Macoilin PF09726.9 ADV21961.1 - 0.24 9.9 10.7 0.27 9.7 10.7 1.1 1 0 0 1 1 1 0 Macoilin family SOG2 PF10428.9 ADV21961.1 - 3.8 6.6 16.9 4.5 6.4 16.9 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein SPX PF03105.19 ADV21961.1 - 4.7 7.0 11.0 5.7 6.7 11.0 1.1 1 0 0 1 1 1 0 SPX domain GREB1 PF15782.5 ADV21961.1 - 8.2 3.4 7.4 9.7 3.2 7.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Iso_dh PF00180.20 ADV21962.1 - 3.8e-95 319.0 0.0 5.8e-94 315.1 0.0 1.9 1 1 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase UPF0160 PF03690.13 ADV21963.1 - 1.1e-135 452.3 0.0 1.3e-135 452.1 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) GTP_CH_N PF12471.8 ADV21963.1 - 0.0064 16.3 0.0 0.011 15.6 0.0 1.3 1 0 0 1 1 1 1 GTP cyclohydrolase N terminal Bystin PF05291.11 ADV21964.1 - 1.5e-127 424.9 0.0 1.9e-127 424.6 0.0 1.1 1 0 0 1 1 1 1 Bystin YABBY PF04690.13 ADV21965.1 - 7e-06 26.7 0.4 7.2e-06 26.7 0.4 1.0 1 0 0 1 1 1 1 YABBY protein HMG_box_2 PF09011.10 ADV21965.1 - 7.5e-05 23.2 2.6 9.2e-05 23.0 2.6 1.1 1 0 0 1 1 1 1 HMG-box domain Ccdc124 PF06244.12 ADV21965.1 - 0.0037 17.8 2.6 0.0042 17.6 2.6 1.1 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 124 /Oxs1 HMG_box PF00505.19 ADV21965.1 - 0.0058 17.0 2.5 0.012 16.1 2.5 1.5 1 1 0 1 1 1 1 HMG (high mobility group) box MatE PF01554.18 ADV21966.1 - 3.6e-49 166.5 21.6 1.6e-25 89.6 4.9 2.7 2 1 1 3 3 3 2 MatE Polysacc_synt_C PF14667.6 ADV21966.1 - 4.2e-06 26.9 5.7 4.2e-06 26.9 5.7 3.4 3 1 0 3 3 3 1 Polysaccharide biosynthesis C-terminal domain RhoGEF PF00621.20 ADV21967.1 - 1.3e-56 191.8 0.0 2e-56 191.1 0.0 1.4 1 0 0 1 1 1 1 RhoGEF domain LRR_8 PF13855.6 ADV21967.1 - 2.1e-12 46.6 3.2 6.5e-07 29.0 2.4 2.8 2 0 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 ADV21967.1 - 1.9e-07 31.3 8.1 2.1e-05 24.8 3.2 3.9 3 1 1 4 4 4 1 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 ADV21967.1 - 0.00043 20.1 0.6 3 8.1 0.2 3.9 3 0 0 3 3 3 2 Leucine Rich repeat LRR_1 PF00560.33 ADV21967.1 - 0.0011 19.3 10.9 0.84 10.4 0.3 5.8 4 1 0 4 4 4 2 Leucine Rich Repeat COS PF18568.1 ADV21967.1 - 0.18 11.8 0.1 0.75 9.8 0.1 2.1 1 0 0 1 1 1 0 TRIM C-terminal subgroup One Signature domain Y_phosphatase2 PF03162.13 ADV21968.1 - 7e-36 123.3 0.0 8.8e-36 123.0 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family RNA_lig_T4_1 PF09511.10 ADV21969.1 - 2.7e-99 331.5 0.1 5.2e-99 330.5 0.1 1.5 1 0 0 1 1 1 1 RNA ligase tRNA_lig_kinase PF08303.11 ADV21969.1 - 1.3e-19 70.9 0.0 3.1e-19 69.7 0.0 1.6 1 0 0 1 1 1 1 tRNA ligase kinase domain tRNA_lig_CPD PF08302.11 ADV21969.1 - 7.6e-14 51.8 0.2 9.5e-13 48.2 0.0 2.5 2 1 0 2 2 2 1 Fungal tRNA ligase phosphodiesterase domain CDC27 PF09507.10 ADV21969.1 - 0.06 12.7 9.9 0.11 11.9 9.9 1.3 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Acetyltransf_1 PF00583.25 ADV21970.1 - 3.8e-09 36.8 0.0 4.6e-09 36.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ADV21970.1 - 1e-05 25.5 0.0 1.4e-05 25.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ADV21970.1 - 3.4e-05 24.2 0.0 4.8e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ADV21970.1 - 0.0012 18.8 0.0 0.0017 18.3 0.0 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_4 PF13420.7 ADV21970.1 - 0.0054 16.9 0.0 0.0066 16.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Flu_NS2 PF00601.19 ADV21971.1 - 0.21 11.9 0.3 0.37 11.1 0.3 1.4 1 0 0 1 1 1 0 Influenza non-structural protein (NS2) SET PF00856.28 ADV21972.1 - 5.6e-16 59.4 0.1 2.9e-15 57.1 0.1 2.3 1 1 0 1 1 1 1 SET domain SET_assoc PF11767.8 ADV21972.1 - 3.7e-07 29.7 0.0 8.3e-07 28.6 0.0 1.6 1 0 0 1 1 1 1 Histone lysine methyltransferase SET associated N-SET PF11764.8 ADV21972.1 - 8.8e-06 25.9 0.2 8.8e-06 25.9 0.2 3.7 2 1 1 3 3 3 1 COMPASS (Complex proteins associated with Set1p) component N RRM_1 PF00076.22 ADV21972.1 - 0.00019 21.2 0.0 0.0005 19.8 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Hap4_Hap_bind PF10297.9 ADV21973.1 - 1.8e-05 24.7 1.4 1.8e-05 24.7 1.4 2.4 3 0 0 3 3 3 1 Minimal binding motif of Hap4 for binding to Hap2/3/5 bZIP_1 PF00170.21 ADV21973.1 - 0.0007 19.6 16.5 0.0044 17.1 4.3 2.7 3 0 0 3 3 3 2 bZIP transcription factor HALZ PF02183.18 ADV21973.1 - 0.0019 18.4 0.8 0.0041 17.3 0.8 1.6 1 0 0 1 1 1 1 Homeobox associated leucine zipper TMCO5 PF14992.6 ADV21973.1 - 0.16 11.5 3.6 0.23 11.0 3.6 1.1 1 0 0 1 1 1 0 TMCO5 family UPF0449 PF15136.6 ADV21973.1 - 0.85 10.1 3.8 3.2 8.3 3.8 2.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0449 DMPK_coil PF08826.10 ADV21973.1 - 3.1 8.0 7.4 4.2 7.5 2.0 2.3 2 0 0 2 2 2 0 DMPK coiled coil domain like ArgJ PF01960.18 ADV21974.1 - 6.9e-141 469.3 0.0 7.9e-141 469.1 0.0 1.0 1 0 0 1 1 1 1 ArgJ family ATP-grasp PF02222.22 ADV21974.1 - 0.03 13.9 0.1 0.049 13.2 0.1 1.3 1 0 0 1 1 1 0 ATP-grasp domain RNA_pol_Rpb2_6 PF00562.28 ADV21975.1 - 1.3e-127 426.1 0.8 3.7e-127 424.6 0.2 1.9 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 ADV21975.1 - 2.9e-51 173.9 0.0 2.9e-51 173.9 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_7 PF04560.20 ADV21975.1 - 2.1e-32 111.3 0.4 4.9e-32 110.2 0.4 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_3 PF04565.16 ADV21975.1 - 2.9e-25 88.2 0.1 6.8e-25 87.0 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_2 PF04561.14 ADV21975.1 - 6.8e-25 87.8 0.0 1.4e-24 86.8 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_4 PF04566.13 ADV21975.1 - 5.3e-22 77.9 1.0 8.8e-22 77.2 0.3 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_5 PF04567.17 ADV21975.1 - 1.5e-19 70.3 0.2 4.3e-19 68.8 0.2 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 MRNIP PF15749.5 ADV21975.1 - 0.036 14.8 1.2 0.09 13.5 1.2 1.7 1 0 0 1 1 1 0 MRN-interacting protein PH_4 PF15404.6 ADV21976.1 - 3.4e-18 66.1 1.1 1.3e-17 64.2 1.1 2.0 1 1 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 ADV21976.1 - 1.6e-06 28.6 0.1 0.18 12.3 0.0 3.5 3 2 0 3 3 3 2 PH domain E1-E2_ATPase PF00122.20 ADV21977.1 - 2e-39 135.0 2.1 2.1e-39 134.9 0.1 2.1 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 ADV21977.1 - 6.7e-31 107.4 7.1 1.6e-26 93.2 0.9 3.1 2 1 1 3 3 3 2 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 ADV21977.1 - 6.2e-22 77.5 0.1 1.4e-21 76.3 0.1 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 ADV21977.1 - 2.1e-16 60.8 0.3 8.2e-16 58.9 0.3 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 ADV21977.1 - 3.7e-09 36.1 0.1 1.6e-08 34.1 0.0 2.2 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 ADV21977.1 - 0.00016 21.5 0.2 0.0043 16.8 0.2 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Ferlin_C PF16165.5 ADV21977.1 - 0.13 12.2 0.4 3.2 7.7 0.0 2.8 2 0 0 2 2 2 0 Ferlin C-terminus DUF2963 PF11178.8 ADV21977.1 - 1.3 8.8 3.2 0.88 9.3 0.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2963) Arginase PF00491.21 ADV21978.1 - 1.2e-88 297.2 0.0 1.5e-88 296.9 0.0 1.0 1 0 0 1 1 1 1 Arginase family UPF0489 PF12640.7 ADV21978.1 - 0.057 13.6 0.4 0.086 13.1 0.4 1.2 1 0 0 1 1 1 0 UPF0489 domain Polysacc_deac_1 PF01522.21 ADV21979.1 - 2.9e-27 95.0 0.0 5.4e-27 94.2 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase SPX PF03105.19 ADV21979.1 - 0.039 13.9 3.4 0.05 13.5 3.4 1.1 1 0 0 1 1 1 0 SPX domain Apt1 PF10351.9 ADV21979.1 - 2.5 6.9 7.1 3.6 6.3 7.1 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain FMN_dh PF01070.18 ADV21980.1 - 6.7e-114 380.5 0.1 1.1e-113 379.9 0.1 1.3 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 ADV21980.1 - 2.1e-22 79.0 0.0 3.6e-22 78.3 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.17 ADV21980.1 - 7e-08 32.0 0.1 1.3e-07 31.2 0.1 1.4 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 ADV21980.1 - 4.7e-05 22.6 3.6 5.6e-05 22.3 1.4 2.3 3 1 1 4 4 4 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.15 ADV21980.1 - 0.00058 19.3 0.0 0.0011 18.5 0.0 1.4 1 0 0 1 1 1 1 Nitronate monooxygenase His_biosynth PF00977.21 ADV21980.1 - 0.0012 18.4 0.6 0.37 10.2 0.1 2.6 3 0 0 3 3 3 2 Histidine biosynthesis protein DHO_dh PF01180.21 ADV21980.1 - 0.0049 16.1 0.1 0.036 13.3 0.0 2.0 2 0 0 2 2 2 1 Dihydroorotate dehydrogenase Dus PF01207.17 ADV21980.1 - 0.03 13.4 0.2 0.24 10.5 0.0 2.4 1 1 1 2 2 2 0 Dihydrouridine synthase (Dus) ThiG PF05690.14 ADV21980.1 - 0.035 13.4 0.1 7.3 5.8 0.0 2.4 2 0 0 2 2 2 0 Thiazole biosynthesis protein ThiG Jiv90 PF14901.6 ADV21980.1 - 0.16 12.1 0.0 16 5.7 0.0 2.8 3 0 0 3 3 3 0 Cleavage inducing molecular chaperone Ribosomal_L18 PF17135.4 ADV21981.1 - 1.4e-87 291.9 0.8 1.6e-87 291.8 0.8 1.0 1 0 0 1 1 1 1 Ribosomal protein 60S L18 and 50S L18e Ribosomal_L27A PF00828.19 ADV21981.1 - 0.00033 21.3 0.1 0.00088 19.9 0.1 1.8 1 1 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Dimerisation PF08100.11 ADV21981.1 - 0.15 12.1 0.2 1.7 8.7 0.0 2.2 2 0 0 2 2 2 0 Dimerisation domain CAP PF00188.26 ADV21982.1 - 9.4e-19 68.5 0.8 9.4e-19 68.5 0.8 2.2 2 0 0 2 2 2 1 Cysteine-rich secretory protein family SOG2 PF10428.9 ADV21982.1 - 0.22 10.7 10.0 0.24 10.5 10.0 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein SWI-SNF_Ssr4 PF08549.10 ADV21982.1 - 0.72 8.4 4.1 0.97 8.0 4.1 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) Tape_meas_lam_C PF09718.10 ADV21982.1 - 2.6 8.2 7.5 1.1 9.5 0.3 3.1 3 0 0 3 3 3 0 Lambda phage tail tape-measure protein (Tape_meas_lam_C) FSA_C PF10479.9 ADV21982.1 - 6.8 4.7 15.0 8.7 4.3 15.0 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Prenyltransf PF01255.19 ADV21983.1 - 3.2e-56 190.4 0.2 1.7e-53 181.5 0.2 2.0 1 1 0 1 1 1 1 Putative undecaprenyl diphosphate synthase DUF2034 PF10356.9 ADV21986.1 - 0.0095 15.4 0.0 0.015 14.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2034) HD_4 PF13328.6 ADV21987.1 - 1.1e-21 77.2 0.5 1.4e-21 76.9 0.0 1.4 2 0 0 2 2 2 1 HD domain HD PF01966.22 ADV21987.1 - 0.0019 18.4 0.1 0.0076 16.5 0.1 2.1 2 1 0 2 2 2 1 HD domain Coatomer_E PF04733.14 ADV21988.1 - 9.3e-33 113.9 0.7 1.3e-32 113.4 0.7 1.2 1 0 0 1 1 1 1 Coatomer epsilon subunit TPR_4 PF07721.14 ADV21988.1 - 0.44 11.3 4.5 7.4 7.5 1.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 ADV21988.1 - 3.6 8.2 8.9 2 9.0 1.1 3.1 3 1 0 3 3 3 0 Tetratricopeptide repeat PIP5K PF01504.18 ADV21989.1 - 8.3e-42 143.3 0.3 3.5e-34 118.3 0.3 2.3 1 1 1 2 2 2 2 Phosphatidylinositol-4-phosphate 5-Kinase Cpn60_TCP1 PF00118.24 ADV21989.1 - 1.1e-28 100.2 0.0 2.1e-28 99.2 0.0 1.4 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family FYVE PF01363.21 ADV21989.1 - 8.1e-16 57.9 13.4 1.9e-15 56.8 13.4 1.6 1 0 0 1 1 1 1 FYVE zinc finger Ribosomal_S27e PF01667.17 ADV21989.1 - 0.62 9.8 2.5 1.6 8.5 2.5 1.6 1 0 0 1 1 1 0 Ribosomal protein S27 AAA PF00004.29 ADV21990.1 - 4.4e-39 133.9 0.0 7e-39 133.3 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ADV21990.1 - 5.9e-08 32.4 0.0 1.2e-07 31.4 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain RuvB_N PF05496.12 ADV21990.1 - 1.5e-05 24.8 0.0 3e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 ADV21990.1 - 2.2e-05 24.9 0.2 0.00069 20.0 0.1 2.3 1 1 0 2 2 2 1 AAA ATPase domain AAA_14 PF13173.6 ADV21990.1 - 4.7e-05 23.4 0.0 0.00014 21.9 0.0 1.9 2 0 0 2 2 1 1 AAA domain AAA_5 PF07728.14 ADV21990.1 - 6.4e-05 23.0 0.2 0.00093 19.2 0.2 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ADV21990.1 - 0.00025 21.3 0.3 0.015 15.5 0.1 2.4 1 1 1 2 2 2 1 AAA domain AAA_33 PF13671.6 ADV21990.1 - 0.00032 20.9 0.0 0.00056 20.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 ADV21990.1 - 0.00076 18.9 0.2 0.018 14.4 0.1 2.4 2 0 0 2 2 2 1 KaiC Mg_chelatase PF01078.21 ADV21990.1 - 0.0044 16.4 0.1 0.01 15.2 0.1 1.5 2 0 0 2 2 1 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 ADV21990.1 - 0.0053 17.1 0.0 0.011 16.1 0.0 1.6 1 0 0 1 1 1 1 RNA helicase AAA_25 PF13481.6 ADV21990.1 - 0.0058 16.2 0.1 0.063 12.8 0.1 2.2 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 ADV21990.1 - 0.0058 17.2 0.0 0.011 16.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain TniB PF05621.11 ADV21990.1 - 0.0061 16.0 0.0 2.7 7.3 0.0 2.4 2 0 0 2 2 2 1 Bacterial TniB protein AAA_2 PF07724.14 ADV21990.1 - 0.007 16.5 0.0 0.019 15.1 0.0 1.7 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) NACHT PF05729.12 ADV21990.1 - 0.008 16.1 0.9 0.021 14.7 0.2 2.0 2 1 0 2 2 2 1 NACHT domain Viral_helicase1 PF01443.18 ADV21990.1 - 0.0082 15.9 0.0 0.014 15.2 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase IstB_IS21 PF01695.17 ADV21990.1 - 0.0097 15.7 0.1 0.021 14.6 0.1 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein Sigma54_activat PF00158.26 ADV21990.1 - 0.011 15.4 0.1 0.12 12.1 0.1 2.2 1 1 0 1 1 1 0 Sigma-54 interaction domain DUF815 PF05673.13 ADV21990.1 - 0.011 14.9 0.0 0.018 14.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Zeta_toxin PF06414.12 ADV21990.1 - 0.012 14.9 0.1 0.022 14.0 0.1 1.3 1 0 0 1 1 1 0 Zeta toxin Rad17 PF03215.15 ADV21990.1 - 0.014 15.4 0.2 0.094 12.6 0.1 2.0 1 1 0 2 2 2 0 Rad17 P-loop domain TsaE PF02367.17 ADV21990.1 - 0.016 15.2 0.0 0.031 14.3 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activ_2 PF14532.6 ADV21990.1 - 0.024 14.7 0.0 0.06 13.5 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain TIP49 PF06068.13 ADV21990.1 - 0.026 13.7 0.1 0.07 12.3 0.1 1.6 1 1 1 2 2 2 0 TIP49 P-loop domain ABC_tran PF00005.27 ADV21990.1 - 0.037 14.5 0.1 0.11 13.0 0.0 1.6 1 1 0 1 1 1 0 ABC transporter AAA_24 PF13479.6 ADV21990.1 - 0.044 13.5 0.1 0.084 12.6 0.1 1.5 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 ADV21990.1 - 0.045 13.3 0.0 0.11 12.0 0.0 1.6 2 0 0 2 2 1 0 P-loop containing dynein motor region AAA_17 PF13207.6 ADV21990.1 - 0.067 13.6 0.1 0.18 12.3 0.1 1.7 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 ADV21990.1 - 0.09 13.0 0.1 0.18 12.1 0.1 1.5 1 0 0 1 1 1 0 AAA domain WAK_assoc PF14380.6 ADV21990.1 - 0.12 13.1 0.0 0.27 12.0 0.0 1.5 1 0 0 1 1 1 0 Wall-associated receptor kinase C-terminal CPT PF07931.12 ADV21990.1 - 0.12 12.2 0.0 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_3 PF07726.11 ADV21990.1 - 0.12 12.2 0.0 0.23 11.3 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Parvo_NS1 PF01057.17 ADV21990.1 - 0.15 11.1 0.0 0.24 10.4 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 SKI PF01202.22 ADV21990.1 - 0.19 11.8 0.0 0.42 10.7 0.0 1.6 1 0 0 1 1 1 0 Shikimate kinase Complex1_51K PF01512.17 ADV21991.1 - 5.5e-49 165.9 0.0 8.3e-49 165.3 0.0 1.3 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase 51 Kd subunit NADH_4Fe-4S PF10589.9 ADV21991.1 - 9.9e-31 105.7 0.3 2.1e-30 104.6 0.3 1.6 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region SLBB PF10531.9 ADV21991.1 - 1.3e-08 34.6 0.0 3.6e-08 33.1 0.0 1.8 2 0 0 2 2 2 1 SLBB domain DUF3568 PF12092.8 ADV21991.1 - 0.084 13.0 0.5 0.16 12.1 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3568) Mito_carr PF00153.27 ADV21992.1 - 4.2e-58 193.3 8.0 4.1e-21 74.7 0.1 4.1 3 1 0 3 3 3 3 Mitochondrial carrier protein FAM199X PF15814.5 ADV21992.1 - 0.2 10.7 1.5 0.36 9.8 1.5 1.3 1 0 0 1 1 1 0 Protein family FAM199X DUF727 PF05303.12 ADV21993.1 - 0.0012 18.8 0.0 0.0016 18.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF727) SNF2_N PF00176.23 ADV21994.1 - 3e-54 184.1 0.0 5.4e-54 183.2 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain zf-PHD-like PF15446.6 ADV21994.1 - 2e-05 24.3 9.9 2.7e-05 23.8 3.4 2.4 1 1 0 2 2 2 2 PHD/FYVE-zinc-finger like domain ResIII PF04851.15 ADV21994.1 - 0.0014 18.7 0.0 0.0031 17.5 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Chromo PF00385.24 ADV21994.1 - 0.066 13.1 0.5 1.1 9.2 0.0 2.6 2 0 0 2 2 2 0 Chromo (CHRromatin Organisation MOdifier) domain PHD PF00628.29 ADV21994.1 - 0.64 9.9 19.0 1.8 8.5 0.2 4.2 4 1 0 4 4 4 0 PHD-finger RRN3 PF05327.11 ADV21995.1 - 2.9e-166 554.3 0.0 3.9e-166 553.9 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor RRN3 cNMP_binding PF00027.29 ADV21996.1 - 6.2e-27 93.5 0.0 4.1e-14 52.4 0.0 5.2 5 0 0 5 5 5 4 Cyclic nucleotide-binding domain Patatin PF01734.22 ADV21996.1 - 3.4e-18 66.6 6.1 2.9e-10 40.7 3.8 3.2 1 1 0 2 2 2 2 Patatin-like phospholipase tRNA-synt_1g PF09334.11 ADV21997.1 - 1.2e-134 448.9 0.0 1.6e-134 448.6 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 ADV21997.1 - 0.00063 18.1 0.1 0.0015 16.9 0.0 1.7 2 0 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 ADV21997.1 - 0.0036 17.3 1.4 0.016 15.2 0.0 2.6 3 0 0 3 3 3 1 Anticodon-binding domain of tRNA DUF4407 PF14362.6 ADV21997.1 - 1.3 8.3 5.3 2 7.7 5.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CLIP1_ZNF PF16641.5 ADV21998.1 - 0.028 14.3 1.3 0.062 13.2 1.3 1.6 1 0 0 1 1 1 0 CLIP1 zinc knuckle HDA2-3 PF11496.8 ADV21998.1 - 0.041 13.0 0.1 0.11 11.7 0.1 1.7 1 0 0 1 1 1 0 Class II histone deacetylase complex subunits 2 and 3 DUF2373 PF10180.9 ADV22000.1 - 6.9e-20 70.7 0.0 1.4e-19 69.7 0.0 1.5 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2373) UMP1 PF05348.11 ADV22001.1 - 2.2e-30 105.3 0.1 3e-30 104.9 0.1 1.2 1 0 0 1 1 1 1 Proteasome maturation factor UMP1 FAA_hydro_N_2 PF18288.1 ADV22001.1 - 0.058 13.8 0.2 0.11 12.9 0.2 1.6 1 0 0 1 1 1 0 Fumarylacetoacetase N-terminal domain 2 Metallophos PF00149.28 ADV22002.1 - 6.1e-13 49.7 2.7 1.2e-12 48.8 2.7 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase YmdB PF13277.6 ADV22002.1 - 0.097 12.0 0.2 0.21 10.9 0.0 1.6 2 0 0 2 2 2 0 YmdB-like protein HLH PF00010.26 ADV22003.1 - 1.9e-10 40.5 0.1 3.1e-10 39.8 0.1 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Rox3 PF08633.10 ADV22003.1 - 0.62 10.3 2.9 0.85 9.9 1.6 2.0 2 1 0 2 2 2 0 Rox3 mediator complex subunit Na_H_Exchanger PF00999.21 ADV22004.1 - 8.7e-74 248.6 36.3 1.1e-73 248.2 36.3 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family VIT1 PF01988.19 ADV22004.1 - 0.39 10.6 0.0 0.39 10.6 0.0 3.1 4 1 0 4 4 4 0 VIT family CAP_GLY PF01302.25 ADV22005.1 - 3.6e-10 39.7 0.0 6.7e-10 38.9 0.0 1.4 1 0 0 1 1 1 1 CAP-Gly domain LRR_4 PF12799.7 ADV22005.1 - 1e-09 38.5 9.9 0.0091 16.4 0.0 5.0 4 1 0 5 5 5 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ADV22005.1 - 2.2e-05 24.1 12.3 0.18 11.6 0.0 5.3 3 2 2 5 5 5 3 Leucine rich repeat LRR_1 PF00560.33 ADV22005.1 - 6 7.8 15.8 11 7.1 0.0 6.6 6 1 0 6 6 6 0 Leucine Rich Repeat PP-binding PF00550.25 ADV22006.1 - 6.6e-14 52.0 0.9 9.2e-14 51.6 0.9 1.2 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.6 ADV22006.1 - 1.3e-06 28.6 1.0 1.7e-06 28.2 1.0 1.1 1 0 0 1 1 1 1 Acyl-carrier Ribosomal_L50 PF10501.9 ADV22006.1 - 0.13 12.4 0.0 0.23 11.6 0.0 1.5 1 1 0 1 1 1 0 Ribosomal subunit 39S UCR_14kD PF02271.16 ADV22007.1 - 4.7e-34 116.4 0.8 5.9e-34 116.0 0.8 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex 14kD subunit Ribosomal_S24e PF01282.19 ADV22008.1 - 5.1e-33 112.9 0.1 5.1e-33 112.9 0.1 1.5 2 0 0 2 2 2 1 Ribosomal protein S24e INCENP_ARK-bind PF03941.15 ADV22009.1 - 1.3e-19 69.9 1.3 5.4e-19 67.9 1.3 2.2 2 0 0 2 2 2 1 Inner centromere protein, ARK binding region Ecl1 PF12855.7 ADV22010.1 - 0.0009 20.4 9.3 0.0009 20.4 9.3 3.7 2 1 1 3 3 3 1 ECL1/2/3 zinc binding proteins WD40 PF00400.32 ADV22011.1 - 4.3e-13 49.5 0.5 0.0011 19.8 0.0 4.0 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV22011.1 - 2e-05 24.8 0.0 0.0047 17.2 0.0 2.8 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain MAGE_N PF12440.8 ADV22011.1 - 10 6.9 13.7 0.67 10.7 6.5 2.4 2 0 0 2 2 2 0 Melanoma associated antigen family N terminal Peptidase_M16_C PF05193.21 ADV22012.1 - 7.1e-18 65.3 0.0 2.4e-13 50.5 0.0 3.1 2 1 0 2 2 2 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 ADV22012.1 - 5.8e-09 36.1 0.1 4.3e-07 30.0 0.0 2.8 2 1 0 2 2 2 1 Insulinase (Peptidase family M16) M16C_assoc PF08367.11 ADV22012.1 - 4.1e-06 26.1 5.2 0.00015 21.0 0.0 2.5 2 0 0 2 2 2 2 Peptidase M16C associated YidC_periplas PF14849.6 ADV22012.1 - 0.089 12.7 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 YidC periplasmic domain AAA PF00004.29 ADV22013.1 - 1.7e-48 164.4 0.0 3.7e-41 140.6 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ADV22013.1 - 1.2e-10 41.0 0.0 2.8e-10 39.8 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 ADV22013.1 - 5.6e-07 30.1 0.1 0.0001 22.7 0.0 3.7 3 1 0 3 3 2 1 AAA ATPase domain Bromodomain PF00439.25 ADV22013.1 - 8.4e-06 25.8 0.0 2.5e-05 24.3 0.0 1.7 1 0 0 1 1 1 1 Bromodomain AAA_2 PF07724.14 ADV22013.1 - 3.7e-05 23.9 0.0 0.00011 22.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 ADV22013.1 - 6.4e-05 23.0 0.0 0.00022 21.3 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 ADV22013.1 - 0.00038 20.2 0.0 0.0025 17.6 0.0 2.1 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_22 PF13401.6 ADV22013.1 - 0.0025 18.1 0.2 0.03 14.6 0.1 2.7 2 1 0 2 2 2 1 AAA domain RuvB_N PF05496.12 ADV22013.1 - 0.0097 15.7 0.1 0.15 11.8 0.0 2.8 2 1 1 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain AAA_30 PF13604.6 ADV22013.1 - 0.016 15.0 0.1 0.068 12.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 ADV22013.1 - 0.017 15.1 0.0 0.071 13.0 0.0 2.2 2 0 0 2 2 1 0 NACHT domain RNA_helicase PF00910.22 ADV22013.1 - 0.017 15.5 0.0 0.058 13.8 0.0 1.9 1 0 0 1 1 1 0 RNA helicase AAA_25 PF13481.6 ADV22013.1 - 0.022 14.4 0.0 0.079 12.5 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 ADV22013.1 - 0.023 14.9 0.0 0.023 14.9 0.0 3.2 4 0 0 4 4 4 0 AAA domain AAA_28 PF13521.6 ADV22013.1 - 0.029 14.6 0.0 0.09 13.0 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 ADV22013.1 - 0.051 14.1 0.0 0.22 12.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 ADV22013.1 - 0.053 12.9 0.1 0.13 11.6 0.1 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_7 PF12775.7 ADV22013.1 - 0.055 13.0 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_3 PF07726.11 ADV22013.1 - 0.063 13.1 0.0 0.15 12.0 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 ADV22013.1 - 0.086 13.4 0.0 0.47 11.0 0.0 2.3 1 0 0 1 1 1 0 ABC transporter AAA_11 PF13086.6 ADV22013.1 - 0.15 11.8 4.3 0.92 9.2 0.0 3.2 3 0 0 3 3 2 0 AAA domain TsaE PF02367.17 ADV22013.1 - 0.18 11.8 0.0 0.39 10.7 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Parvo_NS1 PF01057.17 ADV22013.1 - 0.22 10.6 0.6 0.72 8.9 0.0 2.0 3 0 0 3 3 3 0 Parvovirus non-structural protein NS1 AAA_2 PF07724.14 ADV22014.1 - 5.1e-38 130.9 0.0 6.1e-29 101.3 0.0 2.2 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA PF00004.29 ADV22014.1 - 1.5e-14 54.5 0.0 2.7e-14 53.7 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 ADV22014.1 - 2.1e-11 43.7 0.0 4.1e-11 42.8 0.0 1.5 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.14 ADV22014.1 - 3.3e-06 27.2 0.1 7.7e-06 25.9 0.1 1.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 ADV22014.1 - 1.9e-05 24.1 0.7 0.0018 17.7 0.1 3.0 2 1 0 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_22 PF13401.6 ADV22014.1 - 6.4e-05 23.2 0.2 0.00043 20.6 0.2 2.3 1 1 0 1 1 1 1 AAA domain MCM PF00493.23 ADV22014.1 - 0.00037 19.7 0.2 0.00061 19.0 0.2 1.3 1 0 0 1 1 1 1 MCM P-loop domain Sigma54_activat PF00158.26 ADV22014.1 - 0.00064 19.5 0.0 0.0072 16.0 0.0 2.2 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_7 PF12775.7 ADV22014.1 - 0.00092 18.8 0.0 0.002 17.7 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region IstB_IS21 PF01695.17 ADV22014.1 - 0.0024 17.7 0.0 0.0047 16.7 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_16 PF13191.6 ADV22014.1 - 0.0049 17.3 0.1 0.038 14.4 0.0 2.1 1 1 1 2 2 2 1 AAA ATPase domain PhoH PF02562.16 ADV22014.1 - 0.011 15.2 0.0 0.019 14.4 0.0 1.2 1 0 0 1 1 1 0 PhoH-like protein AAA_33 PF13671.6 ADV22014.1 - 0.015 15.5 0.0 0.034 14.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 ADV22014.1 - 0.037 14.0 0.0 0.069 13.2 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DEAD PF00270.29 ADV22014.1 - 0.039 13.7 0.6 0.078 12.7 0.6 1.7 1 1 0 1 1 1 0 DEAD/DEAH box helicase SKI PF01202.22 ADV22014.1 - 0.042 14.0 0.1 0.096 12.8 0.0 1.6 2 0 0 2 2 1 0 Shikimate kinase T2SSE PF00437.20 ADV22014.1 - 0.042 12.9 0.0 0.067 12.2 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein RuvB_N PF05496.12 ADV22014.1 - 0.058 13.1 0.3 0.26 11.0 0.1 2.1 2 1 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain AAA_24 PF13479.6 ADV22014.1 - 0.059 13.1 0.0 0.094 12.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain Sigma54_activ_2 PF14532.6 ADV22014.1 - 0.068 13.3 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_28 PF13521.6 ADV22014.1 - 0.12 12.6 0.0 0.23 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 ADV22014.1 - 0.12 12.4 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 ADV22014.1 - 0.15 11.6 0.0 0.24 11.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.13 ADV22014.1 - 0.22 10.7 0.0 0.42 9.8 0.0 1.4 1 0 0 1 1 1 0 TIP49 P-loop domain ATPase PF06745.13 ADV22014.1 - 0.22 10.8 0.1 0.54 9.6 0.1 1.5 2 0 0 2 2 2 0 KaiC IPT PF01745.16 ADV22014.1 - 0.24 10.8 0.0 0.39 10.1 0.0 1.2 1 0 0 1 1 1 0 Isopentenyl transferase TrwB_AAD_bind PF10412.9 ADV22014.1 - 0.27 10.1 0.2 1.2 7.9 0.1 1.8 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain Ribosomal_S2 PF00318.20 ADV22015.1 - 7e-48 162.7 0.0 2e-24 86.0 0.0 2.1 1 1 1 2 2 2 2 Ribosomal protein S2 His_Phos_1 PF00300.22 ADV22016.1 - 1.8e-31 109.3 3.2 1.7e-28 99.7 0.6 3.0 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 1) Cyanate_lyase PF02560.14 ADV22017.1 - 7.3e-34 115.4 0.1 1.1e-33 114.8 0.1 1.3 1 0 0 1 1 1 1 Cyanate lyase C-terminal domain HTH_31 PF13560.6 ADV22017.1 - 0.049 14.0 0.0 0.083 13.2 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain DapH_N PF08503.10 ADV22018.1 - 0.038 14.2 0.0 0.047 13.9 0.0 1.1 1 0 0 1 1 1 0 Tetrahydrodipicolinate succinyltransferase N-terminal zf-RING_UBOX PF13445.6 ADV22019.1 - 1.7e-05 24.7 0.1 3.2e-05 23.9 0.1 1.5 1 0 0 1 1 1 1 RING-type zinc-finger CLTH PF10607.9 ADV22019.1 - 2.2e-05 24.4 0.0 0.00026 20.9 0.0 2.4 1 1 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain zf-RING_2 PF13639.6 ADV22019.1 - 0.025 14.9 0.2 0.047 14.0 0.2 1.5 1 0 0 1 1 1 0 Ring finger domain zf-RING_5 PF14634.6 ADV22019.1 - 0.064 13.2 0.1 0.12 12.3 0.1 1.4 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4 PF00097.25 ADV22019.1 - 0.1 12.5 0.1 0.2 11.5 0.1 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Tudor_3 PF18115.1 ADV22020.1 - 0.00012 21.8 0.0 0.00029 20.6 0.0 1.6 1 0 0 1 1 1 1 DNA repair protein Crb2 Tudor domain BRCT_2 PF16589.5 ADV22020.1 - 0.00053 20.3 0.0 0.013 15.9 0.0 2.8 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain RTT107_BRCT_5 PF16770.5 ADV22020.1 - 0.046 13.6 0.0 0.28 11.1 0.0 2.3 3 0 0 3 3 3 0 Regulator of Ty1 transposition protein 107 BRCT domain BRCT_3 PF18428.1 ADV22020.1 - 0.13 12.4 0.0 0.46 10.6 0.0 2.0 2 0 0 2 2 2 0 BRCA1 C Terminus (BRCT) domain MFS_1 PF07690.16 ADV22021.1 - 1.1e-30 106.8 41.0 4.6e-30 104.7 41.5 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily RPAP1_N PF08621.10 ADV22021.1 - 6.9e-05 22.5 0.1 0.0026 17.5 0.1 2.6 2 0 0 2 2 2 1 RPAP1-like, N-terminal LapA_dom PF06305.11 ADV22021.1 - 1.1 9.2 0.0 1.1 9.2 0.0 3.6 3 1 0 3 3 3 0 Lipopolysaccharide assembly protein A domain DUF3180 PF11377.8 ADV22021.1 - 6.4 6.9 13.3 0.19 11.9 5.2 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3180) PITH PF06201.13 ADV22022.1 - 2.2e-37 128.6 0.1 3e-37 128.2 0.1 1.2 1 0 0 1 1 1 1 PITH domain Thioredoxin PF00085.20 ADV22022.1 - 2.7e-13 49.8 0.1 8.7e-13 48.2 0.1 1.8 1 1 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 ADV22022.1 - 0.0092 16.4 0.0 0.25 11.8 0.0 2.4 1 1 0 1 1 1 1 Thioredoxin-like domain Mt_ATP-synt_D PF05873.12 ADV22023.1 - 0.021 14.7 1.0 0.035 13.9 0.3 1.6 2 0 0 2 2 2 0 ATP synthase D chain, mitochondrial (ATP5H) ETRAMP PF09716.10 ADV22023.1 - 0.2 11.7 0.8 1.3 9.2 0.8 2.3 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) DUF4083 PF13314.6 ADV22023.1 - 5.3 7.1 5.8 26 4.8 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4083) RRM_1 PF00076.22 ADV22024.1 - 2.9e-24 84.7 0.0 1.7e-12 47.0 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PUF PF00806.19 ADV22024.1 - 2e-14 52.4 0.0 0.077 12.7 0.0 6.3 6 1 1 7 7 7 4 Pumilio-family RNA binding repeat SUIM_assoc PF16619.5 ADV22024.1 - 0.022 14.8 2.0 0.097 12.8 2.0 2.1 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 RRM_8 PF11835.8 ADV22024.1 - 0.039 14.2 0.0 0.75 10.0 0.0 2.3 2 0 0 2 2 2 0 RRM-like domain RRM_occluded PF16842.5 ADV22024.1 - 0.07 13.0 0.0 2.4 8.1 0.0 2.7 2 0 0 2 2 2 0 Occluded RNA-recognition motif CwfJ_C_2 PF04676.14 ADV22025.1 - 5.2e-31 107.5 0.0 5.2e-31 107.5 0.0 2.0 2 0 0 2 2 2 1 Protein similar to CwfJ C-terminus 2 CwfJ_C_1 PF04677.15 ADV22025.1 - 1.5e-29 102.3 0.2 2.3e-29 101.7 0.2 1.3 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 ATP_bind_1 PF03029.17 ADV22026.1 - 7.7e-80 268.1 0.1 1e-79 267.7 0.1 1.2 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.27 ADV22026.1 - 1.7e-06 27.8 0.2 4.8e-05 23.0 0.2 2.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain cobW PF02492.19 ADV22026.1 - 5.6e-05 22.8 0.0 0.41 10.2 0.0 2.4 2 1 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain MMR_HSR1 PF01926.23 ADV22026.1 - 8.9e-05 22.5 0.0 0.0008 19.5 0.0 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRP54 PF00448.22 ADV22026.1 - 0.00012 21.8 0.0 0.0088 15.7 0.0 2.3 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_16 PF13191.6 ADV22026.1 - 0.0002 21.8 0.0 0.00083 19.8 0.0 2.0 2 1 0 2 2 1 1 AAA ATPase domain G-alpha PF00503.20 ADV22026.1 - 0.00022 20.5 0.0 0.017 14.3 0.0 2.3 2 0 0 2 2 2 1 G-protein alpha subunit AAA_22 PF13401.6 ADV22026.1 - 0.00028 21.2 0.0 0.00083 19.6 0.0 1.8 1 0 0 1 1 1 1 AAA domain FeoB_N PF02421.18 ADV22026.1 - 0.00031 20.3 0.1 0.012 15.1 0.0 2.4 2 0 0 2 2 2 1 Ferrous iron transport protein B AAA_33 PF13671.6 ADV22026.1 - 0.00036 20.7 0.4 0.00082 19.5 0.0 2.0 2 1 0 2 2 1 1 AAA domain NB-ARC PF00931.22 ADV22026.1 - 0.00087 18.5 0.2 0.0022 17.2 0.0 1.7 2 0 0 2 2 2 1 NB-ARC domain AAA_24 PF13479.6 ADV22026.1 - 0.0013 18.4 0.0 0.0027 17.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ADV22026.1 - 0.0014 19.2 0.7 0.0092 16.5 0.0 2.5 3 0 0 3 3 2 1 AAA domain MeaB PF03308.16 ADV22026.1 - 0.0034 16.4 0.0 0.65 8.9 0.0 2.2 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB NACHT PF05729.12 ADV22026.1 - 0.0034 17.3 0.0 0.0064 16.4 0.0 1.4 1 0 0 1 1 1 1 NACHT domain PduV-EutP PF10662.9 ADV22026.1 - 0.0035 17.1 0.2 0.041 13.6 0.0 2.3 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation Arf PF00025.21 ADV22026.1 - 0.0036 16.8 0.0 0.032 13.7 0.0 2.3 3 0 0 3 3 2 1 ADP-ribosylation factor family AAA_7 PF12775.7 ADV22026.1 - 0.0038 16.8 0.0 0.0078 15.7 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region RsgA_GTPase PF03193.16 ADV22026.1 - 0.0051 16.7 0.1 2.8 7.8 0.0 2.9 3 0 0 3 3 3 1 RsgA GTPase SRPRB PF09439.10 ADV22026.1 - 0.0076 15.7 0.0 0.18 11.3 0.0 2.2 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit AAA_30 PF13604.6 ADV22026.1 - 0.01 15.5 0.1 0.03 14.1 0.0 1.7 2 0 0 2 2 1 0 AAA domain FANC_SAP PF18081.1 ADV22026.1 - 0.011 15.9 0.0 0.027 14.6 0.0 1.7 1 0 0 1 1 1 0 Fanconi anemia-associated nuclease SAP domain APS_kinase PF01583.20 ADV22026.1 - 0.014 15.3 0.0 0.03 14.2 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase CAP PF00188.26 ADV22026.1 - 0.014 16.2 0.1 0.035 14.9 0.1 1.6 1 0 0 1 1 1 0 Cysteine-rich secretory protein family ATPase_2 PF01637.18 ADV22026.1 - 0.019 14.9 0.3 0.13 12.1 0.0 2.3 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea NTPase_1 PF03266.15 ADV22026.1 - 0.03 14.2 0.0 0.6 10.0 0.0 2.3 2 0 0 2 2 2 0 NTPase Zeta_toxin PF06414.12 ADV22026.1 - 0.034 13.4 0.4 0.066 12.5 0.0 1.6 2 0 0 2 2 1 0 Zeta toxin Roc PF08477.13 ADV22026.1 - 0.041 14.1 0.0 0.51 10.6 0.0 2.4 2 1 1 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase PRK PF00485.18 ADV22026.1 - 0.054 13.2 0.0 0.3 10.8 0.0 2.2 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family MobB PF03205.14 ADV22026.1 - 0.076 12.9 0.0 0.24 11.3 0.0 1.8 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B CLP1_P PF16575.5 ADV22026.1 - 0.11 12.3 0.0 0.52 10.1 0.0 2.0 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop Viral_helicase1 PF01443.18 ADV22026.1 - 0.22 11.2 0.0 0.39 10.4 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase HALZ PF02183.18 ADV22027.1 - 0.0091 16.2 0.2 0.0091 16.2 0.2 2.0 2 0 0 2 2 2 1 Homeobox associated leucine zipper RGS PF00615.19 ADV22028.1 - 1.6e-10 41.3 0.3 5.4e-05 23.5 0.0 2.3 2 0 0 2 2 2 2 Regulator of G protein signaling domain DUF2182 PF09948.9 ADV22028.1 - 0.018 14.9 0.2 0.027 14.4 0.2 1.2 1 0 0 1 1 1 0 Predicted metal-binding integral membrane protein (DUF2182) MSC PF09402.10 ADV22029.1 - 2.1e-87 293.7 0.0 3.9e-87 292.9 0.0 1.4 1 0 0 1 1 1 1 Man1-Src1p-C-terminal domain HeH PF12949.7 ADV22029.1 - 2.5e-07 30.3 0.0 5.8e-07 29.1 0.0 1.6 1 0 0 1 1 1 1 HeH/LEM domain Keratin_assoc PF09775.9 ADV22029.1 - 0.19 11.4 0.3 0.39 10.4 0.3 1.4 1 0 0 1 1 1 0 Keratinocyte-associated protein 2 Guanylate_kin PF00625.21 ADV22030.1 - 3e-52 177.0 0.0 3.8e-52 176.6 0.0 1.1 1 0 0 1 1 1 1 Guanylate kinase AAA_22 PF13401.6 ADV22030.1 - 2.4e-05 24.6 0.0 3.7e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 ADV22030.1 - 5e-05 23.5 0.0 0.00028 21.1 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ADV22030.1 - 0.00021 21.7 0.0 0.00043 20.7 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 ADV22030.1 - 0.00026 20.9 0.0 0.00053 19.9 0.0 1.5 2 0 0 2 2 1 1 RsgA GTPase AAA_18 PF13238.6 ADV22030.1 - 0.00028 21.4 0.1 0.0025 18.4 0.0 2.3 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.27 ADV22030.1 - 0.00039 20.9 0.0 0.00069 20.1 0.0 1.4 1 0 0 1 1 1 1 ABC transporter Septin PF00735.18 ADV22030.1 - 0.00098 18.5 0.0 0.0014 18.0 0.0 1.2 1 0 0 1 1 1 1 Septin AAA_24 PF13479.6 ADV22030.1 - 0.0043 16.8 0.0 0.014 15.1 0.0 1.7 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 ADV22030.1 - 0.0049 16.9 0.0 0.0086 16.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_7 PF12775.7 ADV22030.1 - 0.0071 15.9 0.2 0.013 15.0 0.0 1.4 2 0 0 2 2 2 1 P-loop containing dynein motor region Rad17 PF03215.15 ADV22030.1 - 0.0073 16.2 0.0 0.01 15.8 0.0 1.2 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_28 PF13521.6 ADV22030.1 - 0.0083 16.4 0.0 0.019 15.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 ADV22030.1 - 0.01 15.7 0.0 0.023 14.6 0.0 1.5 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_29 PF13555.6 ADV22030.1 - 0.011 15.4 0.0 0.022 14.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_14 PF13173.6 ADV22030.1 - 0.011 15.7 0.0 0.022 14.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 ADV22030.1 - 0.012 16.0 0.0 0.019 15.4 0.0 1.4 1 0 0 1 1 1 0 RNA helicase AAA_21 PF13304.6 ADV22030.1 - 0.015 15.2 0.0 0.024 14.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system FtsK_SpoIIIE PF01580.18 ADV22030.1 - 0.019 14.3 0.1 0.056 12.8 0.0 1.7 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_23 PF13476.6 ADV22030.1 - 0.026 15.0 0.1 0.085 13.3 0.0 1.7 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 ADV22030.1 - 0.072 12.7 0.1 0.13 11.9 0.1 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA PF00004.29 ADV22030.1 - 0.079 13.4 0.1 0.17 12.3 0.0 1.6 2 0 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 ADV22030.1 - 0.091 12.5 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain Roc PF08477.13 ADV22030.1 - 0.11 12.8 0.0 0.19 12.0 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase NACHT PF05729.12 ADV22030.1 - 0.12 12.3 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 NACHT domain Adeno_IVa2 PF02456.15 ADV22030.1 - 0.12 11.1 0.0 0.19 10.5 0.0 1.2 1 0 0 1 1 1 0 Adenovirus IVa2 protein IstB_IS21 PF01695.17 ADV22030.1 - 0.14 11.8 0.0 0.25 11.1 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_19 PF13245.6 ADV22030.1 - 0.18 12.1 0.0 0.3 11.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain Arm PF00514.23 ADV22031.1 - 3.7e-95 309.4 12.7 1.1e-13 50.7 0.1 8.4 8 0 0 8 8 8 8 Armadillo/beta-catenin-like repeat IBB PF01749.20 ADV22031.1 - 3.3e-24 85.1 4.9 7.3e-24 84.0 4.5 1.8 2 0 0 2 2 2 1 Importin beta binding domain HEAT_EZ PF13513.6 ADV22031.1 - 1.4e-21 76.6 0.5 6.4e-08 32.9 0.1 5.6 4 2 1 5 5 5 4 HEAT-like repeat Arm_3 PF16186.5 ADV22031.1 - 1.1e-20 72.9 2.2 2.1e-20 72.0 2.2 1.5 1 0 0 1 1 1 1 Atypical Arm repeat HEAT_2 PF13646.6 ADV22031.1 - 1.4e-17 63.9 0.4 1.3e-05 25.5 0.0 5.7 3 2 2 6 6 6 5 HEAT repeats HEAT PF02985.22 ADV22031.1 - 5.4e-16 57.3 0.8 0.00039 20.4 0.0 6.6 7 0 0 7 7 7 3 HEAT repeat Adaptin_N PF01602.20 ADV22031.1 - 4.3e-06 25.6 0.0 0.00063 18.4 0.0 2.6 1 1 2 3 3 3 1 Adaptin N terminal region Arm_2 PF04826.13 ADV22031.1 - 6.8e-06 25.7 0.0 0.014 14.9 0.0 3.6 2 1 2 4 4 4 2 Armadillo-like RICTOR_V PF14668.6 ADV22031.1 - 0.00045 20.4 4.5 0.34 11.2 0.1 4.1 3 2 1 5 5 5 2 Rapamycin-insensitive companion of mTOR, domain 5 V-ATPase_H_C PF11698.8 ADV22031.1 - 0.0021 18.2 0.1 1.8 8.7 0.0 3.9 3 2 2 5 5 5 2 V-ATPase subunit H HEAT_PBS PF03130.16 ADV22031.1 - 0.0027 18.2 0.6 0.68 10.8 0.0 4.2 5 0 0 5 5 5 1 PBS lyase HEAT-like repeat V-ATPase_H_N PF03224.14 ADV22031.1 - 0.13 11.5 0.0 4.1 6.6 0.0 2.8 1 1 0 2 2 2 0 V-ATPase subunit H Mo25 PF08569.11 ADV22031.1 - 0.13 11.6 0.0 0.44 9.8 0.0 1.8 2 0 0 2 2 2 0 Mo25-like SHS2_Rpb7-N PF03876.17 ADV22032.1 - 7.7e-16 58.2 0.0 1.3e-15 57.5 0.0 1.4 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.23 ADV22032.1 - 3.3e-12 46.6 0.0 4.9e-12 46.0 0.0 1.3 1 0 0 1 1 1 1 S1 RNA binding domain DSPc PF00782.20 ADV22033.1 - 4.9e-14 52.3 0.0 3.3e-13 49.6 0.0 2.0 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ADV22033.1 - 0.0056 16.3 0.0 0.0077 15.8 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Coilin_N PF15862.5 ADV22036.1 - 1e-05 25.4 14.4 0.0015 18.3 14.4 2.9 1 1 0 1 1 1 1 Coilin N-terminus Hid1 PF12722.7 ADV22036.1 - 7.2 4.6 14.6 10 4.1 14.6 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein HD_3 PF13023.6 ADV22037.1 - 2.2e-36 125.3 0.0 3.2e-36 124.7 0.0 1.2 1 0 0 1 1 1 1 HD domain HD_2 PF12917.7 ADV22037.1 - 4.5e-12 46.1 0.0 7.1e-12 45.5 0.0 1.2 1 0 0 1 1 1 1 HD containing hydrolase-like enzyme HD PF01966.22 ADV22037.1 - 1.2e-06 28.7 0.0 2.1e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 HD domain Myelin_PLP PF01275.19 ADV22038.1 - 0.98 9.2 4.2 1.1 9.1 4.2 1.1 1 0 0 1 1 1 0 Myelin proteolipid protein (PLP or lipophilin) DnaJ PF00226.31 ADV22039.1 - 5.7e-18 64.8 0.2 5.7e-18 64.8 0.2 2.4 3 0 0 3 3 1 1 DnaJ domain TPR_2 PF07719.17 ADV22039.1 - 4.8e-16 57.5 12.2 0.00013 21.8 0.1 7.4 8 0 0 8 8 6 4 Tetratricopeptide repeat TPR_1 PF00515.28 ADV22039.1 - 4.9e-13 48.3 11.6 4.6e-07 29.4 0.1 6.8 10 0 0 10 10 7 3 Tetratricopeptide repeat TPR_9 PF13371.6 ADV22039.1 - 5.4e-13 48.9 2.3 1.1e-05 25.5 0.3 4.5 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 ADV22039.1 - 7.7e-13 48.7 8.7 3.7e-07 30.6 0.2 5.9 4 2 1 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.6 ADV22039.1 - 7.2e-11 41.7 0.3 0.0022 18.2 0.0 4.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 ADV22039.1 - 1.7e-10 40.4 7.1 5.9e-06 25.9 2.0 3.9 3 1 1 4 4 4 2 TPR repeat TPR_16 PF13432.6 ADV22039.1 - 9.2e-10 39.0 11.0 9e-07 29.4 0.1 4.8 4 1 1 5 5 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 ADV22039.1 - 1.6e-08 34.1 10.6 0.00034 20.6 0.0 6.3 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_14 PF13428.6 ADV22039.1 - 1.7e-06 28.3 12.0 0.0067 17.2 0.0 6.4 5 1 2 7 7 6 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ADV22039.1 - 3.3e-05 24.0 6.2 0.085 13.1 1.6 4.8 3 2 3 6 6 5 2 Anaphase-promoting complex, cyclosome, subunit 3 BTAD PF03704.17 ADV22039.1 - 0.0001 22.7 9.6 0.052 14.0 1.1 4.0 2 1 1 4 4 4 2 Bacterial transcriptional activator domain TPR_20 PF14561.6 ADV22039.1 - 0.00047 20.4 3.1 0.036 14.4 0.1 3.5 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 ADV22039.1 - 0.0011 19.5 11.4 0.034 14.8 0.1 5.4 6 0 0 6 6 4 1 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 ADV22039.1 - 0.0024 18.3 1.0 3.7 8.0 0.1 3.1 4 0 0 4 4 2 2 Alkyl sulfatase dimerisation TPR_12 PF13424.6 ADV22039.1 - 0.0062 16.8 9.0 0.56 10.5 2.2 5.3 4 2 1 5 5 5 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ADV22039.1 - 0.011 15.8 0.4 0.48 10.5 0.0 3.5 2 1 1 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat NARP1 PF12569.8 ADV22039.1 - 0.011 14.7 1.1 0.018 13.9 0.1 1.8 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 Thioredoxin_8 PF13905.6 ADV22039.1 - 0.027 14.8 0.0 0.28 11.5 0.0 2.3 2 0 0 2 2 2 0 Thioredoxin-like TPR_10 PF13374.6 ADV22039.1 - 0.058 13.3 7.5 0.46 10.4 0.1 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat HemY_N PF07219.13 ADV22039.1 - 0.076 13.2 7.1 23 5.2 0.6 4.3 3 1 1 4 4 4 0 HemY protein N-terminus Methyltransf_19 PF04672.12 ADV22039.1 - 0.13 11.7 0.0 0.26 10.8 0.0 1.4 1 0 0 1 1 1 0 S-adenosyl methyltransferase NRBF2_MIT PF17169.4 ADV22039.1 - 0.18 12.0 1.2 20 5.5 0.1 3.1 2 1 0 2 2 2 0 MIT domain of nuclear receptor-binding factor 2 DUF4363 PF14276.6 ADV22039.1 - 0.22 11.7 0.7 22 5.2 0.0 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4363) MIT PF04212.18 ADV22039.1 - 0.41 10.7 4.4 0.62 10.2 0.6 3.3 3 1 1 4 4 2 0 MIT (microtubule interacting and transport) domain Ysc84 PF04366.12 ADV22040.1 - 6.2e-39 132.7 0.1 1e-38 131.9 0.1 1.4 1 0 0 1 1 1 1 Las17-binding protein actin regulator zf-CCCH_4 PF18044.1 ADV22041.1 - 2e-07 30.6 5.6 3.6e-07 29.8 5.6 1.4 1 0 0 1 1 1 1 CCCH-type zinc finger zf-CCCH PF00642.24 ADV22041.1 - 2.9e-06 27.0 3.1 5.1e-06 26.3 3.1 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 ADV22041.1 - 0.00013 21.9 8.7 0.00024 21.1 8.7 1.4 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH_2 PF14608.6 ADV22041.1 - 0.046 14.2 6.8 0.081 13.4 6.8 1.4 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger Cupin_2 PF07883.11 ADV22042.1 - 3.3e-16 58.8 0.6 5.3e-16 58.1 0.6 1.3 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 ADV22042.1 - 1.1e-05 25.3 0.0 1.6e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 AraC-like ligand binding domain MannoseP_isomer PF01050.18 ADV22042.1 - 2.9e-05 24.0 0.0 3.7e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Mannose-6-phosphate isomerase Cupin_3 PF05899.12 ADV22042.1 - 7e-05 22.4 0.1 0.00012 21.7 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF861) Cupin_1 PF00190.22 ADV22042.1 - 8.9e-05 22.1 0.0 0.00012 21.7 0.0 1.2 1 0 0 1 1 1 1 Cupin Cupin_6 PF12852.7 ADV22042.1 - 0.00021 21.1 0.1 0.00029 20.6 0.1 1.3 1 0 0 1 1 1 1 Cupin ARD PF03079.14 ADV22042.1 - 0.011 15.9 0.0 0.019 15.2 0.0 1.4 1 0 0 1 1 1 0 ARD/ARD' family Intein_splicing PF14890.6 ADV22042.1 - 0.11 12.5 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 Intein splicing domain Rad4 PF03835.15 ADV22043.1 - 8.8e-31 106.6 0.0 2.7e-30 105.0 0.0 1.9 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain BHD_3 PF10405.9 ADV22043.1 - 2e-27 95.4 0.1 3.8e-27 94.5 0.1 1.5 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BHD_2 PF10404.9 ADV22043.1 - 9.9e-20 71.3 5.5 9.9e-20 71.3 5.5 4.0 3 1 0 3 3 3 1 Rad4 beta-hairpin domain 2 BHD_1 PF10403.9 ADV22043.1 - 1e-17 63.7 0.0 2.1e-17 62.7 0.0 1.5 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 Transglut_core PF01841.19 ADV22043.1 - 0.0023 18.4 0.2 0.016 15.6 0.2 2.4 1 1 0 1 1 1 1 Transglutaminase-like superfamily SURF2 PF05477.11 ADV22043.1 - 2.5 7.7 6.1 0.34 10.6 0.5 2.2 2 0 0 2 2 2 0 Surfeit locus protein 2 (SURF2) Haspin_kinase PF12330.8 ADV22044.1 - 1.6e-43 149.0 0.0 2.8e-43 148.3 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase PF00069.25 ADV22044.1 - 0.055 12.8 0.0 0.33 10.3 0.0 1.9 1 1 0 1 1 1 0 Protein kinase domain Pyrid_oxidase_2 PF13883.6 ADV22045.1 - 7e-39 133.5 0.0 8.6e-39 133.2 0.0 1.1 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Nup88 PF10168.9 ADV22046.1 - 1.3e-17 62.9 4.6 4.3e-12 44.7 0.0 2.9 3 0 0 3 3 3 2 Nuclear pore component Nup54 PF13874.6 ADV22046.1 - 0.043 13.9 7.9 0.095 12.8 7.4 1.9 1 1 0 1 1 1 0 Nucleoporin complex subunit 54 Apolipoprotein PF01442.18 ADV22046.1 - 1.5 8.6 16.8 9.1 6.1 16.7 2.2 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain DASH_Spc19 PF08287.11 ADV22047.1 - 7.4e-30 103.9 5.6 8.4e-30 103.7 5.6 1.0 1 0 0 1 1 1 1 Spc19 Cue1_U7BR PF18499.1 ADV22047.1 - 0.0015 18.5 1.0 0.003 17.5 1.0 1.4 1 0 0 1 1 1 1 Ubc7p-binding region of Cue1 DcpS_C PF11969.8 ADV22047.1 - 0.1 13.0 0.8 0.14 12.6 0.1 1.5 2 0 0 2 2 2 0 Scavenger mRNA decapping enzyme C-term binding DUF5595 PF18077.1 ADV22047.1 - 0.64 10.1 2.7 1.4 9.1 0.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5595) WHIM1 PF15612.6 ADV22049.1 - 3.1e-05 23.4 0.0 6.7e-05 22.3 0.0 1.6 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 1 WSD PF15613.6 ADV22049.1 - 0.23 11.9 2.6 0.65 10.5 2.1 2.2 1 1 0 1 1 1 0 Williams-Beuren syndrome DDT (WSD), D-TOX E motif DUF4446 PF14584.6 ADV22049.1 - 0.94 9.4 3.7 2.6 8.0 3.7 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) Ribosomal_L17 PF01196.19 ADV22050.1 - 5.5e-37 126.6 0.0 1.4e-36 125.3 0.0 1.6 2 0 0 2 2 2 1 Ribosomal protein L17 DisA-linker PF10635.9 ADV22050.1 - 0.16 11.8 0.0 0.41 10.4 0.0 1.6 2 0 0 2 2 2 0 DisA bacterial checkpoint controller linker region tRNA_anti-codon PF01336.25 ADV22051.1 - 0.00037 20.4 0.1 0.00056 19.9 0.1 1.3 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain RPA_C PF08784.11 ADV22051.1 - 0.0042 17.7 0.0 0.012 16.2 0.0 1.8 1 0 0 1 1 1 1 Replication protein A C terminal Vps5 PF09325.10 ADV22052.1 - 6.9e-73 245.1 8.4 9.7e-73 244.6 8.4 1.2 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.24 ADV22052.1 - 1.4e-23 83.1 0.6 7.4e-23 80.7 0.0 2.3 2 0 0 2 2 2 1 PX domain Pkinase PF00069.25 ADV22054.1 - 4.9e-28 98.2 0.0 6e-28 97.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV22054.1 - 4.3e-16 59.0 0.0 5.2e-16 58.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ADV22054.1 - 7.6e-10 38.1 0.0 1e-09 37.7 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 ADV22054.1 - 0.0012 18.9 0.1 0.0061 16.5 0.1 2.1 2 1 0 3 3 3 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 ADV22054.1 - 0.029 13.3 0.1 0.042 12.8 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Kdo PF06293.14 ADV22054.1 - 0.048 13.0 0.0 0.081 12.3 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Arf PF00025.21 ADV22055.1 - 2.2e-72 242.2 0.0 2.5e-72 242.0 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 ADV22055.1 - 3.9e-15 56.1 0.0 5.7e-15 55.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 ADV22055.1 - 1.9e-14 53.5 0.0 2.5e-14 53.1 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 ADV22055.1 - 1.7e-12 47.2 0.2 3.6e-08 33.0 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 ADV22055.1 - 3.1e-11 43.1 0.0 3.3e-11 43.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 ADV22055.1 - 2.2e-09 37.0 0.0 2.9e-09 36.7 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ADV22055.1 - 2.6e-05 24.3 0.0 3.9e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ADV22055.1 - 0.094 12.2 0.3 0.26 10.8 0.3 1.8 1 1 0 1 1 1 0 Ferrous iron transport protein B NOG1 PF06858.14 ADV22055.1 - 0.1 12.4 0.1 0.19 11.5 0.1 1.4 1 0 0 1 1 1 0 Nucleolar GTP-binding protein 1 (NOG1) 6PF2K PF01591.18 ADV22055.1 - 0.1 11.9 0.1 0.18 11.1 0.0 1.4 2 0 0 2 2 2 0 6-phosphofructo-2-kinase Bap31 PF05529.12 ADV22056.1 - 1.1e-41 141.9 6.6 1.5e-41 141.4 6.6 1.2 1 0 0 1 1 1 1 Bap31/Bap29 transmembrane region Bap31_Bap29_C PF18035.1 ADV22056.1 - 1.3e-13 50.7 3.3 2.2e-13 50.0 3.3 1.4 1 0 0 1 1 1 1 Bap31/Bap29 cytoplasmic coiled-coil domain DivIC PF04977.15 ADV22056.1 - 0.0071 16.1 7.9 0.031 14.0 0.4 3.1 2 1 1 3 3 3 1 Septum formation initiator FAM184 PF15665.5 ADV22056.1 - 0.015 15.1 2.4 0.015 15.1 2.4 1.4 2 0 0 2 2 2 0 Family with sequence similarity 184, A and B ZapB PF06005.12 ADV22056.1 - 0.022 15.2 2.6 0.05 14.1 2.6 1.6 1 0 0 1 1 1 0 Cell division protein ZapB Cortexin PF11057.8 ADV22056.1 - 0.24 11.3 1.5 8 6.4 0.1 2.3 2 0 0 2 2 2 0 Cortexin of kidney CLP1_P PF16575.5 ADV22058.1 - 1.1e-29 103.6 0.0 5.4e-29 101.3 0.0 2.2 1 1 1 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_14 PF13173.6 ADV22058.1 - 0.025 14.6 0.0 0.045 13.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain Adeno_IVa2 PF02456.15 ADV22058.1 - 0.04 12.7 0.0 0.058 12.2 0.0 1.1 1 0 0 1 1 1 0 Adenovirus IVa2 protein CobU PF02283.16 ADV22058.1 - 0.073 12.6 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 Cobinamide kinase / cobinamide phosphate guanyltransferase RNA_helicase PF00910.22 ADV22058.1 - 0.098 13.1 0.0 0.32 11.4 0.0 1.8 1 0 0 1 1 1 0 RNA helicase FtsK_SpoIIIE PF01580.18 ADV22058.1 - 0.15 11.4 0.0 0.25 10.7 0.0 1.2 1 0 0 1 1 1 0 FtsK/SpoIIIE family ATPase_2 PF01637.18 ADV22058.1 - 0.17 11.8 0.0 0.27 11.1 0.0 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea MeaB PF03308.16 ADV22058.1 - 0.22 10.5 0.0 0.34 9.8 0.0 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB PPR_2 PF13041.6 ADV22059.1 - 0.026 14.7 0.0 5 7.4 0.0 2.9 2 0 0 2 2 2 0 PPR repeat family ING PF12998.7 ADV22060.1 - 3e-09 37.4 0.0 6e-09 36.4 0.0 1.5 1 1 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 ADV22060.1 - 8.1e-05 22.4 12.0 0.00014 21.6 12.0 1.4 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.6 ADV22060.1 - 0.0013 18.9 1.5 0.0027 17.9 1.5 1.5 1 0 0 1 1 1 1 PHD-like zinc-binding domain Cytochrom_B558a PF05038.13 ADV22060.1 - 0.29 10.7 1.4 0.77 9.3 1.4 1.7 1 0 0 1 1 1 0 Cytochrome Cytochrome b558 alpha-subunit Mito_fiss_reg PF05308.11 ADV22060.1 - 2.2 8.3 9.0 12 5.9 5.3 2.2 2 0 0 2 2 2 0 Mitochondrial fission regulator UL42 PF17638.2 ADV22060.1 - 3.7 7.5 7.7 9.2 6.3 5.2 2.2 2 0 0 2 2 2 0 HCMV UL42 Ribosomal_S21e PF01249.18 ADV22061.1 - 6.2e-38 128.8 0.4 6.9e-38 128.6 0.4 1.0 1 0 0 1 1 1 1 Ribosomal protein S21e Cupin_8 PF13621.6 ADV22062.1 - 1.6e-48 165.7 0.0 2.1e-48 165.3 0.0 1.1 1 0 0 1 1 1 1 Cupin-like domain Cupin_2 PF07883.11 ADV22062.1 - 0.00056 19.6 0.1 0.023 14.4 0.0 2.4 2 0 0 2 2 2 1 Cupin domain Cupin_4 PF08007.12 ADV22062.1 - 0.0065 16.0 0.0 0.014 14.9 0.0 1.5 1 0 0 1 1 1 1 Cupin superfamily protein JmjC PF02373.22 ADV22062.1 - 0.03 14.8 0.0 0.76 10.2 0.0 2.4 2 0 0 2 2 2 0 JmjC domain, hydroxylase Cupin_6 PF12852.7 ADV22062.1 - 0.067 12.9 0.0 0.18 11.5 0.0 1.6 2 0 0 2 2 2 0 Cupin PP-binding PF00550.25 ADV22063.1 - 7.8e-07 29.4 1.3 1.1e-06 28.9 1.3 1.3 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.6 ADV22063.1 - 0.036 14.3 0.2 0.048 13.9 0.2 1.2 1 0 0 1 1 1 0 Acyl-carrier Ins_P5_2-kin PF06090.12 ADV22064.1 - 8.4e-66 222.7 0.0 9.5e-66 222.5 0.0 1.0 1 0 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase Rif1_N PF12231.8 ADV22065.1 - 0.098 11.6 0.1 0.31 10.0 0.0 1.8 2 0 0 2 2 2 0 Rap1-interacting factor 1 N terminal SSB PF00436.25 ADV22066.1 - 0.00061 19.8 0.0 0.00087 19.3 0.0 1.2 1 0 0 1 1 1 1 Single-strand binding protein family Mitochondr_Som1 PF11093.8 ADV22067.1 - 4.1e-10 39.5 0.1 5.6e-10 39.1 0.1 1.2 1 0 0 1 1 1 1 Mitochondrial export protein Som1 Pkinase PF00069.25 ADV22068.1 - 1.2e-68 231.3 0.0 1.5e-68 231.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV22068.1 - 1.1e-42 146.1 0.0 1.4e-42 145.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ADV22068.1 - 1e-06 28.3 0.0 1.5e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like YrbL-PhoP_reg PF10707.9 ADV22068.1 - 0.017 14.7 0.0 0.025 14.1 0.0 1.2 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Pkinase_fungal PF17667.1 ADV22068.1 - 0.022 13.6 0.0 0.034 12.9 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase FTA2 PF13095.6 ADV22068.1 - 0.065 12.9 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 ADV22068.1 - 0.14 11.5 0.0 0.22 10.8 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 ADV22068.1 - 0.2 11.2 0.0 0.35 10.5 0.0 1.3 1 0 0 1 1 1 0 RIO1 family LRR_4 PF12799.7 ADV22069.1 - 9.3e-05 22.7 2.1 1.6 9.2 0.0 4.6 4 1 0 4 4 4 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 ADV22069.1 - 0.082 13.0 0.0 0.082 13.0 0.0 4.1 5 0 0 5 5 5 0 Leucine Rich repeat LRR_1 PF00560.33 ADV22069.1 - 1.5 9.7 6.3 75 4.5 0.0 5.6 5 1 0 5 5 5 0 Leucine Rich Repeat Glyco_transf_90 PF05686.12 ADV22071.1 - 8.3e-17 61.2 0.0 5.8e-15 55.1 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferase family 90 Polysacc_syn_2C PF08485.10 ADV22071.1 - 0.082 12.6 0.0 0.23 11.2 0.0 1.7 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein C-terminal DCP1 PF06058.13 ADV22073.1 - 4.1e-19 68.6 0.0 7e-19 67.9 0.0 1.3 1 0 0 1 1 1 1 Dcp1-like decapping family RabGAP-TBC PF00566.18 ADV22074.1 - 2.8e-45 154.6 0.0 5.5e-45 153.7 0.0 1.5 1 0 0 1 1 1 1 Rab-GTPase-TBC domain EF-hand_1 PF00036.32 ADV22074.1 - 2.4e-06 26.7 0.3 0.00027 20.3 0.1 2.7 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 ADV22074.1 - 3e-06 27.6 0.2 0.0011 19.4 0.0 3.2 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 ADV22074.1 - 5.1e-06 26.0 0.7 0.00028 20.6 0.2 2.8 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.6 ADV22074.1 - 0.0022 17.8 0.3 0.26 11.2 0.1 2.6 2 0 0 2 2 2 1 EF-hand domain pair GRAM PF02893.20 ADV22074.1 - 0.008 16.0 0.0 0.019 14.8 0.0 1.6 1 0 0 1 1 1 1 GRAM domain Cwf_Cwc_15 PF04889.12 ADV22074.1 - 0.081 12.6 10.3 0.15 11.8 10.3 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein SPARC_Ca_bdg PF10591.9 ADV22074.1 - 0.084 13.2 0.1 0.34 11.2 0.1 2.1 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region KH_1 PF00013.29 ADV22075.1 - 2.5e-08 33.6 0.3 0.00023 20.9 0.1 2.4 2 0 0 2 2 2 2 KH domain Trp_repressor PF01371.19 ADV22075.1 - 0.02 15.0 0.0 0.036 14.2 0.0 1.4 1 0 0 1 1 1 0 Trp repressor protein Ribophorin_I PF04597.14 ADV22076.1 - 3.3e-127 425.3 0.0 3.9e-127 425.1 0.0 1.0 1 0 0 1 1 1 1 Ribophorin I Zds_C PF08632.10 ADV22076.1 - 0.066 13.0 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 Activator of mitotic machinery Cdc14 phosphatase activation C-term MFS_1 PF07690.16 ADV22077.1 - 8.3e-25 87.4 33.9 8.3e-25 87.4 33.9 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1360 PF07098.11 ADV22077.1 - 0.22 11.5 6.4 0.058 13.4 1.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1360) DUF2700 PF10912.8 ADV22077.1 - 1 9.4 6.2 0.34 11.0 0.2 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2700) Mito_carr PF00153.27 ADV22078.1 - 8.1e-39 131.5 0.1 4.1e-16 58.7 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Mg_trans_NIPA PF05653.14 ADV22079.1 - 7e-104 347.1 17.2 1.1e-103 346.4 17.2 1.3 1 1 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 ADV22079.1 - 6.7e-05 23.1 5.1 6.7e-05 23.1 5.1 3.6 3 1 0 3 3 3 1 EamA-like transporter family Rax2 PF12768.7 ADV22079.1 - 0.045 13.2 0.0 0.11 11.9 0.0 1.6 1 0 0 1 1 1 0 Cortical protein marker for cell polarity DUF1129 PF06570.11 ADV22079.1 - 1.9 7.9 5.1 6.7 6.1 3.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) BIR PF00653.21 ADV22080.1 - 6.7e-41 138.8 4.7 2.5e-22 79.3 0.9 2.5 2 0 0 2 2 2 2 Inhibitor of Apoptosis domain AAA_5 PF07728.14 ADV22081.1 - 2.9e-105 348.0 0.0 2.4e-19 69.7 0.0 9.6 9 0 0 9 9 9 9 AAA domain (dynein-related subfamily) AAA_lid_7 PF17867.1 ADV22081.1 - 5.5e-53 177.6 9.8 4e-19 68.8 0.0 5.0 4 0 0 4 4 4 3 Midasin AAA lid domain AAA_3 PF07726.11 ADV22081.1 - 5.7e-29 100.6 0.0 3.3e-09 36.7 0.0 7.3 7 0 0 7 7 6 4 ATPase family associated with various cellular activities (AAA) AAA_lid_5 PF17865.1 ADV22081.1 - 9.3e-23 80.3 0.0 3.1e-21 75.4 0.0 3.1 3 0 0 3 3 2 1 Midasin AAA lid domain AAA PF00004.29 ADV22081.1 - 4.4e-21 75.7 0.0 0.00062 20.2 0.0 6.8 7 0 0 7 7 6 4 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 ADV22081.1 - 1.6e-20 73.4 0.2 1.7e-05 24.4 0.0 5.9 5 0 0 5 5 5 5 P-loop containing dynein motor region Dynein_heavy PF03028.15 ADV22081.1 - 5.3e-18 65.2 0.0 0.006 16.7 0.0 6.2 5 0 0 5 5 5 4 Dynein heavy chain region D6 P-loop domain AAA_6 PF12774.7 ADV22081.1 - 1.6e-16 60.2 0.0 0.066 12.2 0.0 8.2 8 1 0 8 8 8 4 Hydrolytic ATP binding site of dynein motor region Sigma54_activat PF00158.26 ADV22081.1 - 3.2e-14 53.0 0.5 0.0055 16.4 0.1 5.8 6 0 0 6 6 5 3 Sigma-54 interaction domain AAA_18 PF13238.6 ADV22081.1 - 4.1e-13 50.0 0.2 0.12 12.9 0.0 7.1 6 0 0 6 6 6 2 AAA domain AAA_16 PF13191.6 ADV22081.1 - 8.4e-13 49.1 32.1 0.0014 19.0 0.4 9.6 9 2 0 9 9 7 4 AAA ATPase domain AAA_22 PF13401.6 ADV22081.1 - 2.3e-12 47.3 3.7 0.0046 17.2 0.0 7.3 7 0 0 7 7 7 2 AAA domain TsaE PF02367.17 ADV22081.1 - 4.6e-11 42.8 3.1 2.5 8.1 0.0 6.3 6 0 0 6 6 6 3 Threonylcarbamoyl adenosine biosynthesis protein TsaE Mg_chelatase PF01078.21 ADV22081.1 - 5.4e-08 32.5 1.4 5.4 6.3 0.0 7.8 8 0 0 8 8 8 0 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 ADV22081.1 - 7.4e-08 32.5 0.0 0.033 14.2 0.0 5.4 6 0 0 6 6 4 2 AAA domain T2SSE PF00437.20 ADV22081.1 - 1.2e-07 31.1 0.4 0.41 9.6 0.0 4.9 5 0 0 5 5 5 2 Type II/IV secretion system protein Zeta_toxin PF06414.12 ADV22081.1 - 2.2e-07 30.4 0.1 0.56 9.5 0.0 5.8 6 0 0 6 6 6 1 Zeta toxin AAA_19 PF13245.6 ADV22081.1 - 6e-07 29.9 1.1 1.9 8.8 0.2 5.4 4 0 0 4 4 4 1 AAA domain NACHT PF05729.12 ADV22081.1 - 2.8e-06 27.4 4.5 0.6 10.0 0.0 5.6 4 0 0 4 4 4 1 NACHT domain RNA_helicase PF00910.22 ADV22081.1 - 2.9e-06 27.6 0.4 7.1 7.1 0.0 5.6 6 0 0 6 6 5 0 RNA helicase AAA_28 PF13521.6 ADV22081.1 - 6.6e-06 26.5 1.7 1.3 9.2 0.0 5.5 5 0 0 5 5 5 1 AAA domain Sigma54_activ_2 PF14532.6 ADV22081.1 - 9.6e-06 25.8 0.3 0.058 13.5 0.0 4.9 4 0 0 4 4 4 1 Sigma-54 interaction domain AAA_29 PF13555.6 ADV22081.1 - 1.5e-05 24.6 0.5 4.5 7.1 0.0 6.0 7 0 0 7 7 6 0 P-loop containing region of AAA domain AAA_33 PF13671.6 ADV22081.1 - 1.7e-05 25.0 0.2 7.7 6.7 0.0 5.4 5 0 0 5 5 5 0 AAA domain DUF815 PF05673.13 ADV22081.1 - 2.2e-05 23.8 1.1 0.78 8.9 0.0 4.8 5 0 0 5 5 5 1 Protein of unknown function (DUF815) RsgA_GTPase PF03193.16 ADV22081.1 - 2.5e-05 24.2 0.9 5.4 6.9 0.0 4.9 5 0 0 5 5 5 0 RsgA GTPase RuvB_N PF05496.12 ADV22081.1 - 3.1e-05 23.8 0.5 4.5 7.0 0.0 5.7 6 0 0 6 6 6 0 Holliday junction DNA helicase RuvB P-loop domain AAA_25 PF13481.6 ADV22081.1 - 3.9e-05 23.3 4.5 0.96 9.0 0.1 5.8 5 0 0 5 5 5 1 AAA domain ABC_tran PF00005.27 ADV22081.1 - 4.7e-05 23.9 18.2 0.093 13.2 0.0 6.7 7 0 0 7 7 5 2 ABC transporter Rad17 PF03215.15 ADV22081.1 - 6.4e-05 22.9 0.6 28 4.5 0.0 5.9 6 0 0 6 6 6 0 Rad17 P-loop domain AAA_8 PF12780.7 ADV22081.1 - 0.00017 21.0 0.0 0.044 13.1 0.0 3.8 4 0 0 4 4 3 1 P-loop containing dynein motor region D4 DEAD PF00270.29 ADV22081.1 - 0.00038 20.3 0.0 6.5 6.5 0.0 4.2 4 0 0 4 4 3 0 DEAD/DEAH box helicase SRP54 PF00448.22 ADV22081.1 - 0.00056 19.6 0.4 3.1 7.4 0.1 3.8 4 0 0 4 4 3 1 SRP54-type protein, GTPase domain IstB_IS21 PF01695.17 ADV22081.1 - 0.0018 18.1 1.8 1.4 8.6 0.0 5.1 6 0 0 6 6 5 1 IstB-like ATP binding protein TniB PF05621.11 ADV22081.1 - 0.0018 17.7 0.2 19 4.6 0.0 5.2 6 0 0 6 6 4 0 Bacterial TniB protein PduV-EutP PF10662.9 ADV22081.1 - 0.0025 17.5 0.1 4.4 7.0 0.0 3.8 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation dNK PF01712.19 ADV22081.1 - 0.0061 16.4 0.0 1 9.2 0.0 3.0 3 0 0 3 3 2 1 Deoxynucleoside kinase NTPase_1 PF03266.15 ADV22081.1 - 0.0092 15.9 1.0 41 4.0 0.3 4.7 4 0 0 4 4 4 0 NTPase Roc PF08477.13 ADV22081.1 - 0.038 14.2 2.9 51 4.1 0.0 4.6 5 0 0 5 5 4 0 Ras of Complex, Roc, domain of DAPkinase IPT PF01745.16 ADV22081.1 - 0.095 12.1 0.2 18 4.6 0.0 3.5 3 0 0 3 3 3 0 Isopentenyl transferase CPT PF07931.12 ADV22081.1 - 0.32 10.8 4.1 38 4.1 0.0 5.5 5 1 0 5 5 4 0 Chloramphenicol phosphotransferase-like protein ATP_bind_1 PF03029.17 ADV22081.1 - 0.36 10.6 1.5 36 4.0 0.1 3.5 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein Stealth_CR2 PF11380.8 ADV22082.1 - 8e-11 42.1 0.1 4e-10 39.8 0.0 2.2 2 0 0 2 2 2 1 Stealth protein CR2, conserved region 2 Stealth_CR3 PF17102.5 ADV22082.1 - 2.5e-09 36.9 0.1 5.7e-09 35.7 0.1 1.7 1 0 0 1 1 1 1 Stealth protein CR3, conserved region 3 Sugar_tr PF00083.24 ADV22083.1 - 3.4e-31 108.6 25.5 9.7e-31 107.1 25.6 1.8 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ADV22083.1 - 6e-30 104.4 30.9 6e-30 104.4 30.9 2.3 2 1 1 3 3 3 1 Major Facilitator Superfamily C_GCAxxG_C_C PF09719.10 ADV22083.1 - 0.38 11.0 1.5 5.1 7.4 0.1 2.9 3 0 0 3 3 3 0 Putative redox-active protein (C_GCAxxG_C_C) MFAP1 PF06991.11 ADV22084.1 - 1.7e-42 145.7 27.6 1.7e-42 145.7 27.6 3.6 2 1 1 3 3 3 1 Microfibril-associated/Pre-mRNA processing ArfGap PF01412.18 ADV22085.1 - 1.2e-32 112.4 0.0 2.3e-32 111.5 0.0 1.5 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf PH PF00169.29 ADV22085.1 - 3.8e-07 30.6 0.4 3.5e-06 27.5 0.4 2.2 1 1 0 1 1 1 1 PH domain PH_9 PF15410.6 ADV22085.1 - 0.14 12.5 0.0 0.52 10.7 0.0 1.9 2 0 0 2 2 2 0 Pleckstrin homology domain SVIP PF15811.5 ADV22085.1 - 0.64 10.5 5.4 0.75 10.3 0.1 2.9 2 0 0 2 2 2 0 Small VCP/p97-interacting protein CRIM PF16978.5 ADV22087.1 - 7.8e-39 133.0 0.0 2.1e-38 131.6 0.0 1.7 2 0 0 2 2 2 1 SAPK-interacting protein 1 (Sin1), middle CRIM domain SIN1_PH PF16979.5 ADV22087.1 - 0.00019 21.7 0.2 0.00032 20.9 0.2 1.3 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), Pleckstrin-homology Cyt-b5 PF00173.28 ADV22090.1 - 3.5e-15 55.9 0.1 6.2e-15 55.1 0.1 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain FA_desaturase PF00487.24 ADV22090.1 - 1.3e-14 54.7 19.2 1.3e-14 54.7 19.2 1.8 1 1 1 2 2 2 1 Fatty acid desaturase TPPII PF12580.8 ADV22090.1 - 0.11 11.9 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 Tripeptidyl peptidase II Sec23_trunk PF04811.15 ADV22091.1 - 9.9e-73 244.7 0.0 1.5e-72 244.1 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 ADV22091.1 - 2.8e-30 104.9 0.4 5.1e-30 104.1 0.4 1.5 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 ADV22091.1 - 7.1e-25 86.8 0.1 1.5e-24 85.8 0.1 1.6 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 ADV22091.1 - 2.5e-16 59.4 5.4 5.2e-16 58.4 5.4 1.6 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 ADV22091.1 - 1.4e-14 53.7 0.0 3.1e-14 52.6 0.0 1.6 1 0 0 1 1 1 1 Gelsolin repeat Sld5 PF05916.11 ADV22092.1 - 7e-09 36.1 0.0 9.2e-09 35.7 0.0 1.2 1 0 0 1 1 1 1 GINS complex protein DUF4690 PF15756.5 ADV22093.1 - 0.0087 16.6 0.2 0.0087 16.6 0.2 3.8 4 0 0 4 4 4 1 Small Novel Rich in Cartilage Podoplanin PF05808.11 ADV22093.1 - 0.015 15.4 0.2 0.015 15.4 0.2 4.4 3 1 1 4 4 4 0 Podoplanin Adeno_E3_CR2 PF02439.15 ADV22093.1 - 0.065 13.0 0.1 0.16 11.8 0.1 1.6 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 DUF5013 PF16405.5 ADV22093.1 - 0.13 12.5 6.1 1 9.6 0.3 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF5013) SAP18 PF06487.12 ADV22094.1 - 1.4e-28 99.8 0.0 2e-28 99.4 0.0 1.1 1 0 0 1 1 1 1 Sin3 associated polypeptide p18 (SAP18) Pkinase PF00069.25 ADV22095.1 - 9.8e-74 248.0 0.0 1.2e-73 247.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV22095.1 - 9.6e-34 116.8 0.0 1.3e-33 116.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 ADV22095.1 - 1.1e-12 48.4 1.3 2.9e-12 47.1 1.3 1.8 1 0 0 1 1 1 1 Protein kinase C terminal domain Haspin_kinase PF12330.8 ADV22095.1 - 1.1e-07 31.2 0.1 1.7e-07 30.5 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 ADV22095.1 - 0.0001 21.7 0.0 0.00025 20.5 0.0 1.6 2 0 0 2 2 2 1 Kinase-like FTA2 PF13095.6 ADV22095.1 - 0.015 14.9 0.0 0.87 9.2 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 ADV22095.1 - 0.05 13.0 0.0 0.086 12.2 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family ADH_N PF08240.12 ADV22096.1 - 2.3e-29 101.4 0.3 6.4e-29 100.0 0.3 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ADV22096.1 - 3.8e-17 62.5 0.3 1e-16 61.1 0.3 1.7 1 1 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 ADV22096.1 - 1.4e-05 24.7 1.5 0.021 14.3 0.2 3.0 2 1 1 3 3 3 2 Glucose dehydrogenase C-terminus UDPG_MGDP_dh_N PF03721.14 ADV22096.1 - 0.00011 21.8 0.1 0.0002 21.0 0.1 1.4 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ADH_zinc_N_2 PF13602.6 ADV22096.1 - 0.0041 18.2 0.1 0.042 14.9 0.0 2.7 2 2 2 4 4 4 1 Zinc-binding dehydrogenase Methyltransf_25 PF13649.6 ADV22096.1 - 0.083 13.6 0.6 0.24 12.1 0.4 2.0 2 1 0 2 2 2 0 Methyltransferase domain Methyltransf_18 PF12847.7 ADV22096.1 - 0.17 11.8 0.0 0.37 10.7 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Tam41_Mmp37 PF09139.11 ADV22097.1 - 5.8e-92 308.6 0.0 6.6e-92 308.4 0.0 1.0 1 0 0 1 1 1 1 Phosphatidate cytidylyltransferase, mitochondrial Pcc1 PF09341.10 ADV22098.1 - 1.7e-21 76.1 1.3 2.2e-21 75.8 1.3 1.2 1 0 0 1 1 1 1 Transcription factor Pcc1 JTB PF05439.12 ADV22099.1 - 4.1e-05 23.6 0.1 7.1e-05 22.8 0.1 1.4 1 0 0 1 1 1 1 Jumping translocation breakpoint protein (JTB) Mcl1_mid PF12341.8 ADV22100.1 - 2.7e-97 325.7 0.0 8.6e-96 320.8 0.0 2.4 2 1 0 2 2 2 1 Minichromosome loss protein, Mcl1, middle region WD40 PF00400.32 ADV22100.1 - 4.8e-17 62.0 10.1 0.00012 22.8 0.2 7.3 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV22100.1 - 5.2e-16 58.7 0.0 9.9e-06 25.8 0.0 5.0 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain IKI3 PF04762.12 ADV22100.1 - 0.00038 18.6 0.0 0.00061 17.9 0.0 1.2 1 0 0 1 1 1 1 IKI3 family eIF2A PF08662.11 ADV22100.1 - 0.01 15.7 0.1 0.41 10.5 0.1 2.8 2 1 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ADV22100.1 - 0.011 15.7 2.3 4.1 7.5 0.0 4.1 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 ADV22100.1 - 0.18 10.7 0.0 7.3 5.5 0.0 2.4 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Gal4_dimer PF03902.13 ADV22100.1 - 0.27 11.4 1.5 0.58 10.4 1.5 1.4 1 0 0 1 1 1 0 Gal4-like dimerisation domain Yip1 PF04893.17 ADV22102.1 - 0.12 12.1 0.0 0.12 12.1 0.0 3.0 3 0 0 3 3 3 0 Yip1 domain UPF0182 PF03699.13 ADV22102.1 - 0.16 10.1 2.6 0.24 9.5 2.6 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0182) ATE_C PF04377.15 ADV22104.1 - 1.6e-41 142.1 0.0 2.7e-41 141.4 0.0 1.4 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, C terminus ATE_N PF04376.13 ADV22104.1 - 5.6e-06 26.7 1.0 1.2e-05 25.6 1.0 1.6 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, N terminus Ras PF00071.22 ADV22105.1 - 1.8e-41 141.5 0.0 5.2e-39 133.5 0.0 2.1 2 0 0 2 2 2 2 Ras family Roc PF08477.13 ADV22105.1 - 6.7e-31 107.0 0.0 1e-30 106.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ADV22105.1 - 1.4e-13 50.7 0.0 1.6e-12 47.2 0.0 2.0 2 0 0 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ADV22105.1 - 0.00016 21.7 0.0 0.00049 20.2 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ADV22105.1 - 0.001 18.5 0.0 0.0016 17.8 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_24 PF13479.6 ADV22105.1 - 0.11 12.2 0.0 0.44 10.3 0.1 1.8 2 0 0 2 2 2 0 AAA domain SRPRB PF09439.10 ADV22105.1 - 0.14 11.6 0.0 0.24 10.8 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit UNC-50 PF05216.13 ADV22106.1 - 6.6e-78 261.3 13.1 7.6e-78 261.1 13.1 1.0 1 0 0 1 1 1 1 UNC-50 family RR_TM4-6 PF06459.12 ADV22107.1 - 0.32 10.8 5.9 0.47 10.2 5.9 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 ADH_zinc_N PF00107.26 ADV22108.1 - 3.2e-13 49.8 0.6 1.2e-12 47.9 0.1 2.2 3 1 0 3 3 3 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ADV22108.1 - 3.6e-05 23.6 0.1 0.0001 22.1 0.1 1.8 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_N_2 PF16884.5 ADV22108.1 - 0.027 14.3 0.1 0.11 12.4 0.0 2.1 2 1 0 2 2 2 0 N-terminal domain of oxidoreductase Acetyltransf_1 PF00583.25 ADV22109.1 - 1.6e-14 54.1 0.1 2.4e-14 53.6 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 ADV22109.1 - 3.7e-11 42.8 0.1 6.3e-11 42.1 0.1 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.7 ADV22109.1 - 2.1e-10 40.6 0.1 3e-10 40.1 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ADV22109.1 - 1.8e-09 37.9 0.1 2.8e-09 37.3 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 ADV22109.1 - 4.8e-06 26.3 0.1 1.1e-05 25.2 0.0 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ADV22109.1 - 9.5e-06 25.7 0.0 2.5e-05 24.3 0.0 1.6 1 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 ADV22109.1 - 0.00035 21.2 0.0 0.0005 20.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain PanZ PF12568.8 ADV22109.1 - 0.0087 15.8 0.1 0.012 15.3 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain, PanZ Acetyltransf_CG PF14542.6 ADV22109.1 - 0.011 15.8 0.1 0.019 15.1 0.1 1.3 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase GNAT_acetyltran PF12746.7 ADV22109.1 - 0.04 13.5 0.0 0.058 13.0 0.0 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase Acetyltransf_4 PF13420.7 ADV22109.1 - 0.045 13.9 0.0 0.12 12.5 0.0 1.7 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.6 ADV22109.1 - 0.14 12.1 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase WW PF00397.26 ADV22110.1 - 1.2e-10 41.3 1.1 2.3e-10 40.4 1.1 1.5 1 0 0 1 1 1 1 WW domain TPR_2 PF07719.17 ADV22111.1 - 3.5e-23 79.8 5.6 0.066 13.4 0.0 10.2 11 0 0 11 11 11 5 Tetratricopeptide repeat TPR_19 PF14559.6 ADV22111.1 - 2.4e-16 60.0 9.0 3.2e-06 27.6 0.3 6.5 5 1 2 7 7 7 4 Tetratricopeptide repeat TPR_8 PF13181.6 ADV22111.1 - 4.4e-16 57.7 0.1 0.51 10.7 0.0 8.9 9 0 0 9 9 8 3 Tetratricopeptide repeat TPR_1 PF00515.28 ADV22111.1 - 4.2e-15 54.8 6.1 0.03 14.2 0.0 9.2 10 0 0 10 10 10 3 Tetratricopeptide repeat TPR_14 PF13428.6 ADV22111.1 - 8.6e-15 54.2 8.7 0.056 14.3 0.1 8.2 5 2 3 8 8 7 3 Tetratricopeptide repeat TPR_11 PF13414.6 ADV22111.1 - 8.2e-11 41.4 1.0 0.0002 21.0 0.0 5.9 7 1 1 8 8 7 2 TPR repeat TPR_16 PF13432.6 ADV22111.1 - 2.9e-10 40.6 0.0 0.0014 19.2 0.0 5.4 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 ADV22111.1 - 3.4e-10 40.0 5.0 0.01 16.1 0.0 8.0 5 2 4 9 9 8 2 Tetratricopeptide repeat TPR_9 PF13371.6 ADV22111.1 - 1.5e-08 34.6 5.5 8.9e-05 22.6 0.4 5.3 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_17 PF13431.6 ADV22111.1 - 5.7e-08 32.6 0.3 0.32 11.5 0.0 5.9 7 0 0 7 7 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 ADV22111.1 - 1.9e-07 31.2 5.6 0.021 15.5 0.0 7.6 8 0 0 8 8 7 1 Tetratricopeptide repeat NARP1 PF12569.8 ADV22111.1 - 4.9e-07 29.0 0.0 0.018 14.0 0.0 3.3 3 0 0 3 3 3 3 NMDA receptor-regulated protein 1 TPR_7 PF13176.6 ADV22111.1 - 1.6e-05 24.6 1.3 14 6.0 0.0 6.6 6 0 0 6 6 6 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ADV22111.1 - 2.1e-05 24.7 1.1 1.7 8.9 0.0 5.1 5 1 1 6 6 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_20 PF14561.6 ADV22111.1 - 2.5e-05 24.5 0.2 0.14 12.5 0.2 4.8 4 1 1 5 5 4 1 Tetratricopeptide repeat TPR_21 PF09976.9 ADV22111.1 - 0.0035 17.1 0.1 0.01 15.6 0.1 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat-like domain DUF3856 PF12968.7 ADV22111.1 - 0.019 15.0 1.0 10 6.2 0.0 4.6 5 0 0 5 5 5 0 Domain of Unknown Function (DUF3856) TPR_5 PF12688.7 ADV22111.1 - 0.02 15.1 0.1 3 8.1 0.1 4.1 4 1 1 5 5 5 0 Tetratrico peptide repeat TPR_15 PF13429.6 ADV22111.1 - 0.036 13.3 0.2 0.52 9.5 0.0 2.7 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 ADV22111.1 - 0.14 12.0 4.3 3.3 7.7 0.1 4.6 5 0 0 5 5 4 0 Tetratricopeptide repeat Microtub_bind PF13931.6 ADV22111.1 - 0.21 12.0 0.5 0.54 10.6 0.5 1.6 1 0 0 1 1 1 0 Kinesin-associated microtubule-binding Tetraspanin PF00335.20 ADV22112.1 - 8.8e-10 38.7 8.9 1.3e-09 38.1 8.9 1.3 1 0 0 1 1 1 1 Tetraspanin family Sen15 PF09631.10 ADV22113.1 - 1.3e-13 51.1 0.0 2.8e-08 34.0 0.0 2.2 2 0 0 2 2 2 2 Sen15 protein GSH_synth_ATP PF03917.17 ADV22114.1 - 1.1e-127 425.9 0.0 1.3e-127 425.7 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.15 ADV22114.1 - 7.3e-31 106.7 0.0 1.3e-30 105.8 0.0 1.4 1 0 0 1 1 1 1 Eukaryotic glutathione synthase A1_Propeptide PF07966.12 ADV22114.1 - 0.18 11.7 0.0 3.9 7.4 0.0 2.7 2 0 0 2 2 2 0 A1 Propeptide HEAT_2 PF13646.6 ADV22115.1 - 5.1e-06 26.8 4.2 0.0041 17.5 0.1 4.4 3 2 0 3 3 3 2 HEAT repeats HEAT PF02985.22 ADV22115.1 - 2.6e-05 24.1 1.4 7.3 7.1 0.0 5.4 5 0 0 5 5 5 2 HEAT repeat Cnd1 PF12717.7 ADV22115.1 - 0.0046 17.0 3.7 0.028 14.5 0.0 3.8 5 0 0 5 5 5 1 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 ADV22115.1 - 0.0077 16.7 4.3 19 5.9 0.1 5.2 6 0 0 6 6 6 1 HEAT-like repeat Actin PF00022.19 ADV22116.1 - 9.9e-70 235.2 0.0 9.4e-69 232.0 0.0 1.9 1 1 0 1 1 1 1 Actin SURF4 PF02077.15 ADV22117.1 - 2.2e-97 325.8 3.4 2.6e-97 325.6 3.4 1.0 1 0 0 1 1 1 1 SURF4 family YibE_F PF07907.11 ADV22117.1 - 0.028 13.9 3.8 0.13 11.7 2.2 2.1 2 0 0 2 2 2 0 YibE/F-like protein DUF5562 PF17717.1 ADV22117.1 - 0.042 13.8 1.4 0.078 12.9 0.2 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5562) DUF2070 PF09843.9 ADV22117.1 - 4.2 5.6 7.5 7.2 4.8 7.5 1.5 1 1 0 1 1 1 0 Predicted membrane protein (DUF2070) adh_short PF00106.25 ADV22118.1 - 0.0015 18.1 0.0 0.0028 17.2 0.0 1.4 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ADV22118.1 - 0.0053 16.3 0.0 0.04 13.5 0.0 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase TPP_enzyme_N PF02776.18 ADV22119.1 - 3.9e-32 111.2 0.0 6.8e-32 110.4 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 ADV22119.1 - 4.1e-20 71.9 0.0 8e-20 71.0 0.0 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 ADV22119.1 - 1.5e-15 57.3 0.0 8.2e-15 54.9 0.0 2.1 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DXP_synthase_N PF13292.6 ADV22119.1 - 0.061 12.5 0.0 0.1 11.8 0.0 1.3 1 0 0 1 1 1 0 1-deoxy-D-xylulose-5-phosphate synthase MR_MLE_C PF13378.6 ADV22119.1 - 0.14 11.7 0.0 0.27 10.7 0.0 1.4 1 0 0 1 1 1 0 Enolase C-terminal domain-like E1_dh PF00676.20 ADV22119.1 - 0.2 10.6 0.0 0.35 9.8 0.0 1.3 1 0 0 1 1 1 0 Dehydrogenase E1 component Ribosomal_L37 PF08561.10 ADV22120.1 - 6.5e-23 81.5 6.8 9e-21 74.6 6.8 2.1 1 1 0 1 1 1 1 Mitochondrial ribosomal protein L37 AAA PF00004.29 ADV22121.1 - 8.3e-44 149.2 0.0 1.5e-43 148.4 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ADV22121.1 - 3.4e-11 42.8 0.0 6.7e-11 41.8 0.0 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_2 PF07724.14 ADV22121.1 - 2.7e-07 30.9 0.0 6.4e-07 29.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 ADV22121.1 - 3e-06 27.3 0.0 1.5e-05 25.0 0.0 2.1 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ADV22121.1 - 8.3e-06 26.3 0.1 7.2e-05 23.2 0.0 2.2 1 1 0 2 2 2 1 AAA ATPase domain Prot_ATP_ID_OB PF16450.5 ADV22121.1 - 1.5e-05 24.8 0.4 3.4e-05 23.7 0.4 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_18 PF13238.6 ADV22121.1 - 1.6e-05 25.5 0.1 0.0079 16.8 0.0 3.3 3 1 0 3 3 3 1 AAA domain AAA_22 PF13401.6 ADV22121.1 - 3e-05 24.3 0.1 0.0086 16.4 0.0 2.5 1 1 1 2 2 2 1 AAA domain RuvB_N PF05496.12 ADV22121.1 - 7.2e-05 22.6 0.0 0.00019 21.2 0.0 1.8 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 ADV22121.1 - 0.0012 18.1 0.0 0.0027 16.9 0.0 1.5 1 1 0 1 1 1 1 TIP49 P-loop domain AAA_33 PF13671.6 ADV22121.1 - 0.0015 18.7 0.0 0.0033 17.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 ADV22121.1 - 0.002 17.9 0.0 0.0047 16.7 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein PhoH PF02562.16 ADV22121.1 - 0.0064 16.0 0.0 0.15 11.5 0.0 2.3 2 0 0 2 2 2 1 PhoH-like protein Mg_chelatase PF01078.21 ADV22121.1 - 0.0078 15.6 0.1 0.02 14.3 0.1 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 ADV22121.1 - 0.0081 16.0 0.0 0.017 15.0 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 ADV22121.1 - 0.0098 16.1 0.0 0.021 15.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 ADV22121.1 - 0.013 15.3 0.0 0.1 12.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 ADV22121.1 - 0.014 14.7 0.0 0.037 13.4 0.0 1.7 2 0 0 2 2 2 0 KaiC TsaE PF02367.17 ADV22121.1 - 0.02 14.9 0.0 0.038 14.0 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE CENP-Q PF13094.6 ADV22121.1 - 0.022 15.0 0.7 0.053 13.7 0.2 1.9 2 0 0 2 2 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Sigma54_activat PF00158.26 ADV22121.1 - 0.027 14.2 0.1 0.11 12.2 0.0 2.0 3 0 0 3 3 2 0 Sigma-54 interaction domain DUF815 PF05673.13 ADV22121.1 - 0.031 13.4 0.0 0.062 12.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_7 PF12775.7 ADV22121.1 - 0.035 13.6 0.0 0.063 12.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_14 PF13173.6 ADV22121.1 - 0.035 14.1 0.0 0.062 13.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF5406 PF17400.2 ADV22121.1 - 0.037 14.5 0.0 0.087 13.2 0.0 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5406) APG6_N PF17675.1 ADV22121.1 - 0.042 14.4 0.4 0.1 13.1 0.4 1.6 1 0 0 1 1 1 0 Apg6 coiled-coil region RNA_helicase PF00910.22 ADV22121.1 - 0.047 14.1 0.0 0.088 13.2 0.0 1.5 1 0 0 1 1 1 0 RNA helicase DUF2072 PF09845.9 ADV22121.1 - 0.05 13.9 0.0 0.099 12.9 0.0 1.4 1 0 0 1 1 1 0 Zn-ribbon containing protein AAA_25 PF13481.6 ADV22121.1 - 0.058 13.0 0.0 0.18 11.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.17 ADV22121.1 - 0.062 12.4 0.0 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 RILP PF11461.8 ADV22121.1 - 0.073 13.3 0.8 0.16 12.2 0.8 1.5 1 0 0 1 1 1 0 Rab interacting lysosomal protein Zeta_toxin PF06414.12 ADV22121.1 - 0.087 12.1 0.0 0.18 11.0 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin AAA_13 PF13166.6 ADV22121.1 - 0.095 11.3 0.2 4.4 5.8 0.3 2.1 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 ADV22121.1 - 0.12 12.3 0.0 0.65 9.9 0.0 2.0 1 1 1 2 2 2 0 NACHT domain AAA_11 PF13086.6 ADV22121.1 - 0.14 11.9 0.1 0.43 10.3 0.0 1.7 2 0 0 2 2 2 0 AAA domain DivIC PF04977.15 ADV22121.1 - 1 9.2 4.0 2.4 8.0 4.0 1.6 1 0 0 1 1 1 0 Septum formation initiator UQ_con PF00179.26 ADV22122.1 - 1.2e-40 138.4 0.1 1.5e-40 138.1 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 ADV22122.1 - 0.085 12.6 0.0 0.096 12.4 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family B Nup54 PF13874.6 ADV22123.1 - 1.3e-25 90.1 4.7 1.3e-25 90.1 4.7 2.3 2 0 0 2 2 2 1 Nucleoporin complex subunit 54 Nucleoporin_FG PF13634.6 ADV22123.1 - 1.2e-18 67.8 173.6 2.8e-08 34.5 43.7 5.3 1 1 5 6 6 6 6 Nucleoporin FG repeat region EXS PF03124.14 ADV22124.1 - 1e-104 350.4 0.8 1.2e-104 350.2 0.8 1.0 1 0 0 1 1 1 1 EXS family CrgA PF06781.12 ADV22124.1 - 0.063 13.4 0.4 0.19 11.8 0.4 1.9 1 0 0 1 1 1 0 Cell division protein CrgA Serglycin PF04360.12 ADV22124.1 - 0.16 11.9 0.1 0.28 11.1 0.1 1.3 1 0 0 1 1 1 0 Serglycin Ada3 PF10198.9 ADV22125.1 - 2.4e-26 92.5 0.1 2.4e-26 92.5 0.1 2.7 3 0 0 3 3 3 1 Histone acetyltransferases subunit 3 FAM27 PF15832.5 ADV22125.1 - 0.19 12.3 12.3 2 9.0 0.6 2.9 2 0 0 2 2 2 0 FAM27 D and E protein family DUF3915 PF13054.6 ADV22125.1 - 0.99 9.4 18.0 0.6 10.1 8.6 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3915) Trypan_PARP PF05887.11 ADV22126.1 - 0.55 10.2 6.6 0.57 10.2 4.4 1.9 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) PFK PF00365.20 ADV22127.1 - 3.8e-184 610.5 0.0 1.5e-87 293.5 0.0 3.2 3 0 0 3 3 3 3 Phosphofructokinase FAM216B PF15107.6 ADV22127.1 - 0.029 14.2 0.0 0.073 12.9 0.0 1.6 1 0 0 1 1 1 0 FAM216B protein family MRP-L27 PF09809.9 ADV22129.1 - 4.5e-10 39.4 0.0 8.5e-10 38.5 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L27 Arylsulfotran_2 PF14269.6 ADV22130.1 - 1.5e-59 201.8 6.6 2.9e-59 200.9 6.6 1.4 1 0 0 1 1 1 1 Arylsulfotransferase (ASST) Arylsulfotrans PF05935.11 ADV22130.1 - 1.7e-16 60.1 2.3 4e-15 55.6 2.0 2.2 1 1 0 1 1 1 1 Arylsulfotransferase (ASST) RPAP2_Rtr1 PF04181.13 ADV22131.1 - 4.9e-16 58.8 0.1 8.5e-16 58.0 0.1 1.4 1 0 0 1 1 1 1 Rtr1/RPAP2 family Acyl-CoA_dh_1 PF00441.24 ADV22132.1 - 4.2e-32 111.4 0.6 6.2e-32 110.9 0.6 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 ADV22132.1 - 4.1e-13 49.4 0.0 9.8e-13 48.1 0.0 1.7 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 ADV22132.1 - 5.2e-13 49.4 0.7 8.7e-13 48.7 0.7 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 ADV22132.1 - 7e-11 42.8 0.0 1.3e-10 41.9 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain FAA_hydrolase PF01557.18 ADV22133.1 - 3.5e-56 190.3 0.0 4.2e-56 190.0 0.0 1.0 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family KH_2 PF07650.17 ADV22133.1 - 0.0099 15.7 0.4 0.11 12.4 0.1 2.2 2 0 0 2 2 2 1 KH domain Thymidylat_synt PF00303.19 ADV22134.1 - 1.1e-107 359.2 0.0 1.2e-107 359.0 0.0 1.0 1 0 0 1 1 1 1 Thymidylate synthase WD40 PF00400.32 ADV22135.1 - 2.3e-18 66.2 11.0 8.6e-05 23.2 0.1 6.1 6 0 0 6 6 6 4 WD domain, G-beta repeat Nup160 PF11715.8 ADV22135.1 - 0.073 11.7 0.1 7 5.2 0.0 2.7 3 0 0 3 3 3 0 Nucleoporin Nup120/160 hNIFK_binding PF12196.8 ADV22135.1 - 5 6.7 0.0 5 6.7 0.0 3.3 3 0 0 3 3 3 0 FHA Ki67 binding domain of hNIFK AAA PF00004.29 ADV22136.1 - 2.5e-09 37.7 0.0 4.8e-09 36.7 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ADV22136.1 - 3e-06 27.7 0.0 3.2e-05 24.4 0.0 2.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ADV22136.1 - 2.4e-05 24.6 0.0 8.5e-05 22.8 0.0 1.9 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 ADV22136.1 - 2.7e-05 24.0 0.0 4.8e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein NACHT PF05729.12 ADV22136.1 - 0.0041 17.1 0.1 1.3 8.9 0.0 2.4 2 0 0 2 2 2 2 NACHT domain Cdc6_C PF09079.11 ADV22136.1 - 0.011 15.6 0.0 0.025 14.5 0.0 1.6 1 0 0 1 1 1 0 CDC6, C terminal winged helix domain AAA_30 PF13604.6 ADV22136.1 - 0.023 14.4 0.0 0.057 13.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 ADV22136.1 - 0.083 12.4 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AFG1_ATPase PF03969.16 ADV22136.1 - 0.095 11.6 0.0 0.15 10.9 0.0 1.2 1 0 0 1 1 1 0 AFG1-like ATPase AAA_28 PF13521.6 ADV22136.1 - 0.11 12.7 0.1 0.22 11.8 0.1 1.4 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 ADV22136.1 - 0.16 11.1 0.0 0.25 10.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Polysacc_synt_4 PF04669.13 ADV22137.1 - 5.8e-20 71.6 1.0 3e-18 66.1 1.0 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis PPR_2 PF13041.6 ADV22138.1 - 1.8e-21 76.0 1.4 4.7e-08 33.1 0.0 6.2 2 2 4 6 6 6 5 PPR repeat family PPR_3 PF13812.6 ADV22138.1 - 4.8e-17 61.8 0.0 2.1e-06 27.7 0.0 4.2 3 1 1 4 4 4 3 Pentatricopeptide repeat domain PPR PF01535.20 ADV22138.1 - 4.4e-11 42.2 11.1 0.0061 16.7 0.0 7.6 8 0 0 8 8 8 3 PPR repeat PPR_1 PF12854.7 ADV22138.1 - 1.6e-08 34.1 0.0 5.1e-06 26.1 0.0 4.1 4 0 0 4 4 4 1 PPR repeat PPR_long PF17177.4 ADV22138.1 - 8.6e-06 25.3 0.0 0.088 12.2 0.1 3.0 2 1 0 2 2 2 2 Pentacotripeptide-repeat region of PRORP TetR_C_6 PF13977.6 ADV22138.1 - 0.02 15.1 0.5 0.087 13.1 0.5 2.1 1 0 0 1 1 1 0 BetI-type transcriptional repressor, C-terminal DUF3368 PF11848.8 ADV22138.1 - 0.11 12.3 0.3 21 5.0 0.1 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3368) Med12 PF09497.10 ADV22139.1 - 7.3e-17 61.4 0.0 2.6e-16 59.7 0.0 2.1 1 0 0 1 1 1 1 Transcription mediator complex subunit Med12 Med12-LCEWAV PF12145.8 ADV22139.1 - 0.015 14.2 0.1 0.015 14.2 0.1 1.7 2 0 0 2 2 2 0 Eukaryotic Mediator 12 subunit domain AAA PF00004.29 ADV22140.1 - 1.9e-12 47.8 0.0 3.6e-12 46.8 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ADV22140.1 - 4.4e-09 37.0 0.0 4.2e-08 33.7 0.0 2.2 1 1 1 2 2 2 1 AAA ATPase domain IstB_IS21 PF01695.17 ADV22140.1 - 2.3e-06 27.5 0.0 4.1e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein NACHT PF05729.12 ADV22140.1 - 3.3e-06 27.1 0.1 0.019 14.9 0.0 2.3 2 0 0 2 2 2 2 NACHT domain AAA_22 PF13401.6 ADV22140.1 - 8.4e-05 22.9 0.0 0.00018 21.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain Cdc6_C PF09079.11 ADV22140.1 - 0.00035 20.5 0.0 0.00089 19.2 0.0 1.6 1 0 0 1 1 1 1 CDC6, C terminal winged helix domain AAA_30 PF13604.6 ADV22140.1 - 0.00039 20.2 0.1 0.00094 18.9 0.1 1.6 1 0 0 1 1 1 1 AAA domain TIP49 PF06068.13 ADV22140.1 - 0.0034 16.7 0.1 0.0055 15.9 0.1 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain NTPase_1 PF03266.15 ADV22140.1 - 0.0075 16.2 0.1 0.022 14.7 0.1 1.8 1 1 0 1 1 1 1 NTPase AAA_7 PF12775.7 ADV22140.1 - 0.019 14.5 0.0 0.035 13.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_11 PF13086.6 ADV22140.1 - 0.022 14.5 0.0 0.048 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain PIF1 PF05970.14 ADV22140.1 - 0.03 13.5 0.0 0.048 12.8 0.0 1.2 1 0 0 1 1 1 0 PIF1-like helicase RuvB_N PF05496.12 ADV22140.1 - 0.041 13.6 0.0 0.14 11.9 0.0 1.8 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 ADV22140.1 - 0.051 13.6 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.12 ADV22140.1 - 0.054 12.8 0.0 2.4 7.4 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin AAA_28 PF13521.6 ADV22140.1 - 0.055 13.7 0.0 0.11 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_6 PF12774.7 ADV22140.1 - 0.063 12.2 0.2 0.1 11.6 0.2 1.2 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region AAA_19 PF13245.6 ADV22140.1 - 0.063 13.6 0.3 0.2 12.0 0.1 1.8 1 1 0 1 1 1 0 AAA domain CsoSCA PF08936.10 ADV22140.1 - 0.076 11.7 0.0 0.12 11.0 0.0 1.2 1 0 0 1 1 1 0 Carboxysome Shell Carbonic Anhydrase AAA_18 PF13238.6 ADV22140.1 - 0.076 13.6 0.0 0.15 12.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 ADV22140.1 - 0.083 13.3 0.0 0.17 12.3 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_14 PF13173.6 ADV22140.1 - 0.1 12.6 0.0 0.25 11.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 ADV22140.1 - 0.11 12.2 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain DUF815 PF05673.13 ADV22140.1 - 0.15 11.1 0.0 0.29 10.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) CFEM PF05730.11 ADV22141.1 - 1.3e-10 41.2 9.3 2.2e-10 40.5 9.3 1.4 1 0 0 1 1 1 1 CFEM domain Ribosomal_L23 PF00276.20 ADV22142.1 - 2.6e-08 34.1 0.0 6.5e-08 32.8 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein L23 PP28 PF10252.9 ADV22142.1 - 0.059 13.8 1.4 0.11 12.9 1.4 1.5 1 0 0 1 1 1 0 Casein kinase substrate phosphoprotein PP28 SEA PF01390.20 ADV22142.1 - 0.088 12.9 0.0 0.16 12.0 0.0 1.4 1 0 0 1 1 1 0 SEA domain HpcH_HpaI PF03328.14 ADV22144.1 - 1.1e-41 142.5 0.1 4.5e-41 140.4 0.0 1.8 2 0 0 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family C-C_Bond_Lyase PF15617.6 ADV22144.1 - 1.1e-09 38.0 0.0 1e-05 24.9 0.0 2.3 2 1 0 2 2 2 2 C-C_Bond_Lyase of the TIM-Barrel fold FecR PF04773.13 ADV22145.1 - 0.0084 16.7 0.0 0.026 15.1 0.0 1.8 1 1 1 2 2 2 1 FecR protein NUDIX PF00293.28 ADV22146.1 - 4e-08 33.4 0.0 5.3e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain MgtE PF01769.16 ADV22147.1 - 3e-34 118.1 23.4 1.7e-18 67.1 8.2 3.2 2 1 1 3 3 3 2 Divalent cation transporter Phe_tRNA-synt_N PF02912.18 ADV22148.1 - 0.021 14.7 0.6 0.3 11.1 0.2 2.5 2 0 0 2 2 2 0 Aminoacyl tRNA synthetase class II, N-terminal domain MBF1 PF08523.10 ADV22149.1 - 1.7e-18 66.8 0.6 3.7e-18 65.7 0.0 1.8 2 0 0 2 2 2 1 Multiprotein bridging factor 1 HTH_3 PF01381.22 ADV22149.1 - 1.9e-06 27.9 0.1 3.2e-06 27.1 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 ADV22149.1 - 0.002 18.4 0.1 0.0039 17.5 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain TRAP-gamma PF07074.12 ADV22149.1 - 0.27 10.8 0.2 0.4 10.2 0.2 1.2 1 0 0 1 1 1 0 Translocon-associated protein, gamma subunit (TRAP-gamma) Peptidase_C14 PF00656.22 ADV22150.1 - 3.3e-63 213.9 0.0 4e-63 213.7 0.0 1.1 1 0 0 1 1 1 1 Caspase domain Asp PF00026.23 ADV22151.1 - 2.7e-72 243.8 12.0 2.7e-72 243.8 12.0 1.8 2 0 0 2 2 2 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 ADV22151.1 - 3.3e-10 40.5 5.1 3.3e-10 40.5 5.1 3.6 2 2 1 3 3 3 1 Xylanase inhibitor N-terminal Transp_cyt_pur PF02133.15 ADV22154.1 - 7.7e-116 387.4 39.6 8.8e-116 387.3 39.6 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin LapA_dom PF06305.11 ADV22154.1 - 8.1 6.3 5.8 1.9 8.3 0.3 2.9 2 1 1 3 3 3 0 Lipopolysaccharide assembly protein A domain PCI PF01399.27 ADV22155.1 - 2.4e-11 44.1 0.0 4.3e-11 43.2 0.0 1.5 1 0 0 1 1 1 1 PCI domain TPR_2 PF07719.17 ADV22155.1 - 0.0023 17.9 1.0 4.7 7.6 1.1 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat Peptidase_S8 PF00082.22 ADV22156.1 - 6.1e-34 117.6 10.8 1.1e-33 116.7 10.8 1.4 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 ADV22156.1 - 3.4e-12 46.8 0.0 6.2e-12 46.0 0.0 1.4 1 0 0 1 1 1 1 Peptidase inhibitor I9 Retrotran_gag_2 PF14223.6 ADV22157.1 - 0.015 14.9 0.0 0.027 14.1 0.0 1.4 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type NAD_binding_4 PF07993.12 ADV22159.1 - 2.1e-33 115.6 0.0 3.2e-33 115.0 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.28 ADV22159.1 - 4.4e-31 107.9 0.0 1e-30 106.7 0.0 1.6 1 1 0 1 1 1 1 AMP-binding enzyme Epimerase PF01370.21 ADV22159.1 - 1.4e-08 34.5 0.0 3.7e-08 33.1 0.0 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 ADV22159.1 - 1.6e-08 34.8 0.0 3.9e-08 33.5 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site KR PF08659.10 ADV22159.1 - 0.0014 18.6 0.0 0.0029 17.5 0.0 1.6 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 ADV22159.1 - 0.0087 15.2 0.0 0.023 13.9 0.0 1.6 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein DXP_reductoisom PF02670.16 ADV22159.1 - 0.11 13.2 0.0 0.36 11.6 0.0 1.9 1 0 0 1 1 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase ABC_tran PF00005.27 ADV22161.1 - 1.2e-45 155.4 1.1 1.8e-22 80.3 0.0 3.4 3 0 0 3 3 3 2 ABC transporter ABC_tran_Xtn PF12848.7 ADV22161.1 - 5.5e-23 80.8 8.1 5.5e-23 80.8 8.1 3.1 4 0 0 4 4 4 1 ABC transporter AAA_21 PF13304.6 ADV22161.1 - 1.3e-11 44.9 8.1 0.036 13.9 0.1 4.5 2 2 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ADV22161.1 - 5.6e-09 35.8 8.3 0.00084 18.8 0.0 4.7 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ADV22161.1 - 9.2e-07 28.5 0.6 0.01 15.6 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 ADV22161.1 - 2.1e-06 27.8 0.0 0.026 14.6 0.0 3.2 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ADV22161.1 - 7.1e-06 26.0 1.4 0.096 12.6 0.0 2.9 3 0 0 3 3 3 2 RsgA GTPase AAA_22 PF13401.6 ADV22161.1 - 1.3e-05 25.5 0.0 0.17 12.1 0.0 3.2 2 0 0 2 2 2 2 AAA domain AAA_28 PF13521.6 ADV22161.1 - 1.6e-05 25.2 0.1 0.17 12.1 0.1 2.9 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 ADV22161.1 - 1.8e-05 25.2 0.1 0.14 12.6 0.0 2.8 2 0 0 2 2 2 2 AAA ATPase domain AAA_24 PF13479.6 ADV22161.1 - 0.00021 21.1 0.0 0.91 9.2 0.1 2.8 2 0 0 2 2 2 2 AAA domain AAA_23 PF13476.6 ADV22161.1 - 0.00035 21.1 15.8 0.025 15.1 0.0 4.9 5 0 0 5 5 5 2 AAA domain AAA_18 PF13238.6 ADV22161.1 - 0.0007 20.1 1.2 1.4 9.4 0.0 3.8 3 0 0 3 3 3 1 AAA domain NACHT PF05729.12 ADV22161.1 - 0.0012 18.8 0.1 0.27 11.1 0.0 2.5 2 0 0 2 2 2 1 NACHT domain AAA_15 PF13175.6 ADV22161.1 - 0.0014 18.4 9.8 0.22 11.2 0.1 4.4 5 0 0 5 5 5 2 AAA ATPase domain RNA_helicase PF00910.22 ADV22161.1 - 0.0019 18.5 0.0 1.8 9.0 0.0 2.9 2 0 0 2 2 2 1 RNA helicase AAA_25 PF13481.6 ADV22161.1 - 0.0022 17.6 0.2 1.1 8.8 0.0 3.4 5 0 0 5 5 3 1 AAA domain MeaB PF03308.16 ADV22161.1 - 0.0038 16.2 0.2 3.1 6.7 0.0 3.2 3 0 0 3 3 3 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA PF00004.29 ADV22161.1 - 0.0044 17.5 0.4 2.9 8.3 0.1 3.5 3 1 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 ADV22161.1 - 0.0048 16.6 0.2 0.36 10.5 0.0 3.0 3 1 0 3 3 3 1 AAA domain AAA_5 PF07728.14 ADV22161.1 - 0.0057 16.6 0.3 11 6.1 0.0 3.6 4 0 0 4 4 4 0 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 ADV22161.1 - 0.037 13.5 0.0 9.6 5.7 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region FeoB_N PF02421.18 ADV22161.1 - 0.045 13.3 0.3 3.4 7.2 0.0 3.2 3 0 0 3 3 3 0 Ferrous iron transport protein B NTPase_1 PF03266.15 ADV22161.1 - 0.074 13.0 0.1 8 6.3 0.1 2.9 3 0 0 3 3 2 0 NTPase AAA_14 PF13173.6 ADV22161.1 - 0.077 13.0 0.3 17 5.5 0.0 3.4 4 0 0 4 4 3 0 AAA domain AAA_33 PF13671.6 ADV22161.1 - 0.083 13.1 5.8 4.1 7.6 0.0 3.3 4 1 0 4 4 3 0 AAA domain Ploopntkinase3 PF18751.1 ADV22161.1 - 0.1 12.5 0.7 8.4 6.3 0.0 3.0 3 0 0 3 3 2 0 P-loop Nucleotide Kinase3 Roc PF08477.13 ADV22161.1 - 0.1 12.8 0.0 24 5.2 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase SbcCD_C PF13558.6 ADV22161.1 - 0.11 12.7 2.7 4.2 7.7 0.0 4.0 4 2 0 4 4 2 0 Putative exonuclease SbcCD, C subunit Dynamin_N PF00350.23 ADV22161.1 - 0.34 11.0 6.9 0.69 10.0 0.0 3.5 3 1 0 3 3 3 0 Dynamin family DUF87 PF01935.17 ADV22161.1 - 1.3 9.1 0.0 1.3 9.1 0.0 4.3 5 0 0 5 5 5 0 Helicase HerA, central domain UQ_con PF00179.26 ADV22162.1 - 1.6e-37 128.3 2.2 5.7e-37 126.5 0.2 2.0 2 0 0 2 2 2 1 Ubiquitin-conjugating enzyme Piwi PF02171.17 ADV22164.1 - 6.9e-78 261.9 0.0 9.6e-78 261.5 0.0 1.2 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.22 ADV22164.1 - 2.1e-13 50.3 0.1 6.4e-13 48.7 0.1 1.8 1 0 0 1 1 1 1 PAZ domain ArgoN PF16486.5 ADV22164.1 - 9.8e-13 48.9 0.2 4.5e-12 46.7 0.0 2.2 2 0 0 2 2 2 1 N-terminal domain of argonaute ArgoL2 PF16488.5 ADV22164.1 - 8.9e-11 42.0 0.0 3.1e-10 40.2 0.0 2.0 1 0 0 1 1 1 1 Argonaute linker 2 domain ArgoL1 PF08699.10 ADV22164.1 - 9.8e-10 38.0 0.0 3.8e-09 36.1 0.0 2.1 2 0 0 2 2 2 1 Argonaute linker 1 domain ArgoMid PF16487.5 ADV22164.1 - 2.8e-08 33.9 0.1 8.6e-08 32.3 0.1 1.9 1 0 0 1 1 1 1 Mid domain of argonaute Peptidase_S24 PF00717.23 ADV22165.1 - 2.8e-08 33.6 0.1 5e-08 32.8 0.1 1.5 1 0 0 1 1 1 1 Peptidase S24-like DUF4761 PF15958.5 ADV22165.1 - 0.067 13.3 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4761) Swi3 PF07962.12 ADV22167.1 - 8.9e-25 86.5 0.0 1.4e-24 85.9 0.0 1.3 1 0 0 1 1 1 1 Replication Fork Protection Component Swi3 RAP1 PF07218.11 ADV22167.1 - 0.44 8.8 1.7 0.59 8.3 1.7 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Topoisom_bac PF01131.20 ADV22168.1 - 3.6e-105 352.3 0.0 4.4e-105 352.1 0.0 1.1 1 0 0 1 1 1 1 DNA topoisomerase zf-GRF PF06839.12 ADV22168.1 - 4.3e-29 100.3 15.3 2.2e-16 59.7 4.5 2.6 2 0 0 2 2 2 2 GRF zinc finger Toprim PF01751.22 ADV22168.1 - 3.7e-19 68.9 0.0 7.4e-19 67.9 0.0 1.5 1 0 0 1 1 1 1 Toprim domain zf-CCHC PF00098.23 ADV22168.1 - 1.4e-06 28.1 3.0 4.4e-06 26.5 3.0 2.0 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_3 PF13917.6 ADV22168.1 - 0.012 15.5 0.4 0.036 14.0 0.4 1.8 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_2 PF13696.6 ADV22168.1 - 0.095 12.5 7.5 0.021 14.7 3.9 1.8 2 0 0 2 2 2 0 Zinc knuckle F-box-like PF12937.7 ADV22169.1 - 0.027 14.3 0.1 0.067 13.1 0.1 1.7 1 0 0 1 1 1 0 F-box-like Pyridox_ox_2 PF12900.7 ADV22170.1 - 1.7e-05 24.9 0.3 0.00018 21.5 0.3 2.2 1 1 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase PAS PF00989.25 ADV22172.1 - 7.3e-05 22.7 0.0 0.00014 21.8 0.0 1.4 1 0 0 1 1 1 1 PAS fold Zn_clus PF00172.18 ADV22172.1 - 0.00011 22.3 10.7 0.00022 21.3 10.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS_8 PF13188.7 ADV22172.1 - 0.11 12.5 0.0 0.26 11.4 0.0 1.6 1 0 0 1 1 1 0 PAS domain PAS_9 PF13426.7 ADV22172.1 - 0.13 12.5 0.0 0.25 11.6 0.0 1.5 1 0 0 1 1 1 0 PAS domain PAS_4 PF08448.10 ADV22172.1 - 0.18 12.1 0.0 0.36 11.1 0.0 1.5 1 0 0 1 1 1 0 PAS fold Homeodomain PF00046.29 ADV22173.1 - 3.1e-20 71.8 1.3 7e-20 70.6 1.3 1.7 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 ADV22173.1 - 0.0082 16.0 2.2 0.011 15.6 0.3 2.1 2 0 0 2 2 2 1 Homeobox KN domain WAC_Acf1_DNA_bd PF10537.9 ADV22174.1 - 4.4e-27 94.5 0.7 1.1e-26 93.3 0.7 1.7 1 0 0 1 1 1 1 ATP-utilising chromatin assembly and remodelling N-terminal WSD PF15613.6 ADV22174.1 - 1.3e-21 76.9 0.1 1.3e-21 76.9 0.1 3.7 4 0 0 4 4 4 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif DDT PF02791.17 ADV22174.1 - 2.2e-15 56.7 0.1 4.4e-15 55.7 0.1 1.5 1 0 0 1 1 1 1 DDT domain RNase_H2_suC PF08615.11 ADV22174.1 - 0.012 15.8 0.4 1.1 9.5 0.0 2.8 2 0 0 2 2 2 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) GAGA_bind PF06217.12 ADV22174.1 - 1.9 8.7 11.8 1.9 8.7 5.3 2.3 2 0 0 2 2 2 0 GAGA binding protein-like family Cytomega_UL84 PF06284.11 ADV22174.1 - 9 4.6 8.0 15 3.9 8.0 1.2 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein DEAD PF00270.29 ADV22175.1 - 6.3e-38 130.3 0.0 1.6e-37 129.0 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ADV22175.1 - 1.6e-24 86.4 0.3 2e-22 79.6 0.0 2.7 2 1 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ADV22175.1 - 0.00073 19.6 0.1 0.0046 17.0 0.1 2.1 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 ADV22175.1 - 0.0034 16.6 0.0 0.0061 15.8 0.0 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Pro_isomerase PF00160.21 ADV22176.1 - 1.2e-48 165.4 0.1 2.4e-48 164.4 0.0 1.6 2 0 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD zf-NOSIP PF15906.5 ADV22176.1 - 0.0045 17.1 0.5 0.041 14.0 0.0 2.3 2 0 0 2 2 2 1 Zinc-finger of nitric oxide synthase-interacting protein Rtf2 PF04641.12 ADV22176.1 - 0.03 13.7 7.5 3.5 6.9 3.4 3.7 3 1 0 3 3 3 0 Rtf2 RING-finger NDK PF00334.19 ADV22178.1 - 5.5e-51 172.1 0.0 6.8e-51 171.8 0.0 1.1 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Cyclin_N PF00134.23 ADV22179.1 - 2.4e-43 146.9 0.8 4.3e-42 142.8 0.3 2.3 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 ADV22179.1 - 1.8e-33 115.1 0.1 3.3e-33 114.3 0.1 1.4 1 0 0 1 1 1 1 Cyclin, C-terminal domain FAD_binding_2 PF00890.24 ADV22180.1 - 6.4e-82 275.9 1.0 1.1e-81 275.1 0.6 1.5 2 0 0 2 2 2 1 FAD binding domain Cyt-b5 PF00173.28 ADV22180.1 - 5.9e-23 80.8 0.0 2.5e-22 78.8 0.0 2.2 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain DAO PF01266.24 ADV22180.1 - 2.4e-13 50.4 0.3 2.2e-12 47.2 0.3 2.3 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 ADV22180.1 - 7.4e-09 35.7 1.0 9.1e-08 32.2 0.2 3.1 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 ADV22180.1 - 6.7e-08 32.1 1.3 7.2e-07 28.7 0.4 2.7 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 ADV22180.1 - 1.5e-07 31.2 2.6 6e-07 29.2 2.6 1.9 1 1 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.22 ADV22180.1 - 1.5e-05 24.3 0.2 0.0072 15.5 0.5 2.3 2 0 0 2 2 2 2 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 ADV22180.1 - 1.9e-05 24.1 0.0 0.057 12.7 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 ADV22180.1 - 0.0004 19.2 0.3 0.0004 19.2 0.3 2.8 3 0 0 3 3 3 1 HI0933-like protein FAD_binding_3 PF01494.19 ADV22180.1 - 0.00077 18.8 1.9 0.0014 18.0 1.9 1.6 1 1 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 ADV22180.1 - 0.0049 16.1 4.5 0.035 13.3 0.6 2.4 2 0 0 2 2 2 1 Thi4 family AlaDh_PNT_C PF01262.21 ADV22180.1 - 0.014 14.7 1.7 0.015 14.6 0.3 1.7 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_9 PF13454.6 ADV22180.1 - 0.041 13.9 0.4 0.6 10.1 0.4 2.3 1 1 0 1 1 1 0 FAD-NAD(P)-binding Pyr_redox PF00070.27 ADV22180.1 - 0.044 14.4 1.1 0.3 11.7 0.2 2.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 ADV22180.1 - 0.052 12.8 0.2 0.13 11.6 0.2 1.6 1 1 0 1 1 1 0 Flavin containing amine oxidoreductase PSCyt3 PF07627.11 ADV22180.1 - 0.13 12.5 0.0 0.34 11.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1588) RrnaAD PF00398.20 ADV22181.1 - 2e-59 200.9 0.0 2.7e-59 200.4 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 ADV22181.1 - 3.5e-07 30.8 0.0 6.6e-07 29.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ADV22181.1 - 0.00014 22.5 0.0 0.00026 21.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 ADV22181.1 - 0.00052 19.8 0.0 0.00079 19.2 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_12 PF08242.12 ADV22181.1 - 0.0012 19.6 0.0 0.0021 18.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 ADV22181.1 - 0.0032 16.8 0.0 0.006 15.9 0.0 1.4 1 0 0 1 1 1 1 O-methyltransferase domain NodS PF05401.11 ADV22181.1 - 0.0089 15.7 0.0 0.014 15.0 0.0 1.3 1 0 0 1 1 1 1 Nodulation protein S (NodS) Methyltransf_23 PF13489.6 ADV22181.1 - 0.013 15.4 0.0 0.028 14.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 ADV22181.1 - 0.035 13.6 0.0 0.054 13.0 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain CMAS PF02353.20 ADV22181.1 - 0.037 13.3 0.0 0.056 12.7 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase DREV PF05219.12 ADV22181.1 - 0.052 12.7 0.0 0.079 12.0 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase Methyltransf_28 PF02636.17 ADV22181.1 - 0.092 12.4 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase DOT1 PF08123.13 ADV22181.1 - 0.14 11.7 0.0 0.24 10.9 0.0 1.4 1 0 0 1 1 1 0 Histone methylation protein DOT1 Ubie_methyltran PF01209.18 ADV22181.1 - 0.17 11.2 0.0 0.28 10.5 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Ribosomal_S4 PF00163.19 ADV22182.1 - 7.4e-12 46.0 0.8 1.3e-11 45.2 0.8 1.4 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain S4 PF01479.25 ADV22182.1 - 5.1e-11 42.1 0.0 9.5e-11 41.2 0.0 1.4 1 0 0 1 1 1 1 S4 domain MFS_1 PF07690.16 ADV22183.1 - 1.5e-27 96.5 38.8 1.5e-27 96.5 38.8 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ADV22183.1 - 8.7e-07 28.1 34.1 1.4e-06 27.4 33.9 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter GHMP_kinases_C PF08544.13 ADV22183.1 - 0.13 12.7 0.1 0.29 11.5 0.1 1.5 1 0 0 1 1 1 0 GHMP kinases C terminal PUB PF09409.10 ADV22184.1 - 3.1e-13 49.5 0.1 5.7e-13 48.6 0.1 1.5 1 0 0 1 1 1 1 PUB domain Shadoo PF14999.6 ADV22184.1 - 0.049 13.7 1.0 0.08 13.0 1.0 1.3 1 0 0 1 1 1 0 Shadow of prion protein, neuroprotective DUF2498 PF10692.9 ADV22184.1 - 0.061 13.2 0.1 0.37 10.7 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2498) CAF-1_p150 PF11600.8 ADV22184.1 - 0.084 12.6 18.5 0.15 11.8 18.5 1.4 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal DIT1_PvcA PF05141.12 ADV22184.1 - 0.12 11.8 2.0 0.19 11.2 2.0 1.2 1 0 0 1 1 1 0 Pyoverdine/dityrosine biosynthesis protein Jun PF03957.13 ADV22184.1 - 0.38 10.6 4.1 0.54 10.1 4.1 1.2 1 0 0 1 1 1 0 Jun-like transcription factor GFO_IDH_MocA PF01408.22 ADV22185.1 - 7.9e-07 29.9 0.0 1.1e-06 29.5 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold zf-DNA_Pol PF08996.10 ADV22186.1 - 0.0048 16.7 0.1 0.0088 15.8 0.1 1.3 1 0 0 1 1 1 1 DNA Polymerase alpha zinc finger Enolase_C PF00113.22 ADV22187.1 - 7.2e-113 376.7 0.0 9.4e-113 376.3 0.0 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 ADV22187.1 - 3.7e-49 166.2 0.0 6.6e-49 165.4 0.0 1.4 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 ADV22187.1 - 7.7e-09 35.4 0.0 1.5e-08 34.5 0.0 1.3 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 ADV22187.1 - 0.0094 15.1 0.2 0.024 13.8 0.0 1.8 2 0 0 2 2 2 1 Methylaspartate ammonia-lyase C-terminus HPP PF04982.13 ADV22188.1 - 1.2e-38 132.1 5.6 1.7e-38 131.5 5.6 1.2 1 0 0 1 1 1 1 HPP family PIRT PF15099.6 ADV22188.1 - 0.0014 18.2 0.3 0.0026 17.3 0.3 1.5 1 1 0 1 1 1 1 Phosphoinositide-interacting protein family TPPK_C PF12555.8 ADV22188.1 - 0.38 10.8 3.3 5.6 7.1 1.8 3.1 3 0 0 3 3 3 0 Thiamine pyrophosphokinase C terminal MFS_1 PF07690.16 ADV22189.1 - 6e-36 124.1 23.5 6e-36 124.1 23.5 1.6 1 1 1 2 2 2 1 Major Facilitator Superfamily PRT_C PF08372.10 ADV22189.1 - 0.24 11.2 1.2 0.69 9.7 1.2 1.7 1 0 0 1 1 1 0 Plant phosphoribosyltransferase C-terminal Orf78 PF06024.12 ADV22189.1 - 1.5 9.2 5.1 66 3.9 0.5 3.2 3 0 0 3 3 3 0 Orf78 (ac78) DUF1772 PF08592.11 ADV22189.1 - 2.9 8.2 9.4 32 4.8 4.4 3.6 2 2 0 2 2 2 0 Domain of unknown function (DUF1772) Cu-oxidase PF00394.22 ADV22191.1 - 3.4e-37 128.0 1.3 8.3e-33 113.7 0.2 3.3 3 0 0 3 3 3 3 Multicopper oxidase Cu-oxidase_2 PF07731.14 ADV22191.1 - 3e-36 124.2 0.9 3e-36 124.2 0.9 2.1 2 1 0 2 2 2 1 Multicopper oxidase Cu-oxidase_3 PF07732.15 ADV22191.1 - 7.5e-32 109.8 0.3 4e-28 97.8 0.1 3.4 4 0 0 4 4 4 2 Multicopper oxidase La PF05383.17 ADV22192.1 - 6.3e-20 71.0 0.0 1.2e-19 70.1 0.0 1.4 1 0 0 1 1 1 1 La domain RPN1_RPN2_N PF17781.1 ADV22193.1 - 1.1e-106 356.7 0.0 1.9e-106 356.0 0.0 1.4 1 0 0 1 1 1 1 RPN1/RPN2 N-terminal domain RPN1_C PF18051.1 ADV22193.1 - 3e-24 84.8 0.1 6.6e-24 83.7 0.1 1.6 1 0 0 1 1 1 1 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal PC_rep PF01851.22 ADV22193.1 - 5.3e-19 67.6 16.8 0.0078 16.6 0.4 9.2 9 0 0 9 9 9 6 Proteasome/cyclosome repeat HEAT_2 PF13646.6 ADV22193.1 - 4.8e-09 36.5 0.1 0.0071 16.7 0.0 3.6 2 1 1 3 3 3 3 HEAT repeats DPM2 PF07297.12 ADV22194.1 - 3.4e-28 97.7 1.4 3.9e-28 97.5 1.4 1.0 1 0 0 1 1 1 1 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) PIG-P PF08510.12 ADV22194.1 - 0.00014 21.7 1.3 0.00016 21.6 1.3 1.1 1 0 0 1 1 1 1 PIG-P Phage_holin_3_6 PF07332.11 ADV22194.1 - 0.0092 16.0 0.7 0.012 15.6 0.7 1.1 1 0 0 1 1 1 1 Putative Actinobacterial Holin-X, holin superfamily III 2OG-FeII_Oxy_2 PF13532.6 ADV22196.1 - 2.9e-10 40.7 0.0 4e-10 40.2 0.0 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily ALG11_N PF15924.5 ADV22197.1 - 8.7e-76 254.6 0.0 1.7e-75 253.6 0.0 1.5 1 0 0 1 1 1 1 ALG11 mannosyltransferase N-terminus Glycos_transf_1 PF00534.20 ADV22197.1 - 1.3e-24 86.7 0.0 2.4e-24 85.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ADV22197.1 - 1.5e-10 41.6 0.1 3.1e-10 40.6 0.1 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 DUF2834 PF11196.8 ADV22197.1 - 5e-06 26.8 15.1 0.017 15.4 7.6 3.7 2 1 0 2 2 2 2 Protein of unknown function (DUF2834) Glyco_trans_1_2 PF13524.6 ADV22197.1 - 0.11 12.9 0.0 0.21 12.0 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferases group 1 Yae1_N PF09811.9 ADV22198.1 - 2.5e-11 43.1 0.0 4e-11 42.4 0.0 1.3 1 0 0 1 1 1 1 Essential protein Yae1, N terminal F-box-like PF12937.7 ADV22199.1 - 0.00015 21.6 0.4 0.00031 20.6 0.4 1.4 1 0 0 1 1 1 1 F-box-like PDDEXK_6 PF04720.12 ADV22199.1 - 0.12 12.3 0.0 0.27 11.1 0.0 1.5 1 0 0 1 1 1 0 PDDEXK-like family of unknown function KH_1 PF00013.29 ADV22200.1 - 4.3e-47 157.8 5.7 3.7e-17 61.9 0.1 3.2 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 ADV22200.1 - 6.2e-16 58.0 5.3 2.7e-06 27.1 0.2 3.3 3 0 0 3 3 3 3 KH domain KH_4 PF13083.6 ADV22200.1 - 0.00026 20.8 2.5 0.21 11.5 0.0 3.3 3 0 0 3 3 3 1 KH domain KH_5 PF13184.6 ADV22200.1 - 0.00073 19.6 3.8 0.83 9.8 0.0 3.4 3 0 0 3 3 3 2 NusA-like KH domain Ebola_NP PF05505.12 ADV22200.1 - 0.23 9.7 0.5 0.31 9.3 0.5 1.1 1 0 0 1 1 1 0 Ebola nucleoprotein ORC6 PF05460.13 ADV22200.1 - 0.52 9.5 3.2 0.65 9.2 3.2 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) DUF4887 PF16228.5 ADV22200.1 - 1 9.5 9.9 1.8 8.7 9.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4887) Fungal_trans_2 PF11951.8 ADV22204.1 - 3e-38 131.7 0.0 4.7e-38 131.0 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ADV22204.1 - 1.3e-08 34.8 7.0 2.5e-08 33.9 7.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain NDC10_II PF16787.5 ADV22205.1 - 2.1e-56 191.3 0.0 1.5e-55 188.5 0.0 2.1 1 1 0 1 1 1 1 Centromere DNA-binding protein complex CBF3 subunit, domain 2 GCR1_C PF12550.8 ADV22205.1 - 1.1e-15 57.6 0.3 2.3e-15 56.7 0.3 1.5 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes MFS_1 PF07690.16 ADV22206.1 - 4e-15 55.6 20.3 9e-12 44.6 8.8 2.5 2 1 0 2 2 2 2 Major Facilitator Superfamily Pantoate_transf PF02548.15 ADV22207.1 - 3.6e-90 301.8 0.3 2e-89 299.4 0.3 2.0 1 1 0 1 1 1 1 Ketopantoate hydroxymethyltransferase Rsm22 PF09243.10 ADV22207.1 - 1.1e-41 142.9 0.0 4.8e-26 91.6 0.0 2.4 2 0 0 2 2 2 2 Mitochondrial small ribosomal subunit Rsm22 PEP_mutase PF13714.6 ADV22207.1 - 0.00024 20.7 0.1 0.00096 18.7 0.0 1.9 2 0 0 2 2 2 1 Phosphoenolpyruvate phosphomutase Peripla_BP_6 PF13458.6 ADV22207.1 - 0.021 14.5 0.6 5.4 6.6 0.3 2.5 2 1 1 3 3 3 0 Periplasmic binding protein SHMT PF00464.19 ADV22208.1 - 2.9e-176 585.9 0.0 3.4e-176 585.7 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Beta_elim_lyase PF01212.21 ADV22208.1 - 0.023 14.0 0.1 0.088 12.1 0.0 1.9 2 0 0 2 2 2 0 Beta-eliminating lyase tRNA-synt_1b PF00579.25 ADV22210.1 - 1.3e-22 80.5 0.2 2.8e-21 76.1 0.2 2.6 1 1 0 1 1 1 1 tRNA synthetases class I (W and Y) RasGAP PF00616.19 ADV22210.1 - 0.051 13.3 3.1 0.71 9.5 3.1 2.2 1 1 0 1 1 1 0 GTPase-activator protein for Ras-like GTPase 3Beta_HSD PF01073.19 ADV22211.1 - 7.8e-69 231.8 0.0 1.9e-60 204.2 0.0 2.1 2 0 0 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 ADV22211.1 - 1.2e-26 93.7 0.1 1.7e-26 93.2 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ADV22211.1 - 4.3e-14 52.6 0.6 1.1e-10 41.5 0.4 2.8 2 1 0 2 2 2 2 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 ADV22211.1 - 1.2e-09 37.8 0.6 9.6e-06 25.0 0.0 2.3 1 1 1 2 2 2 2 Male sterility protein NAD_binding_10 PF13460.6 ADV22211.1 - 2.1e-08 34.3 0.0 3.3e-08 33.6 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 ADV22211.1 - 1e-05 24.8 0.0 1.9e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 RmlD substrate binding domain TrkA_N PF02254.18 ADV22211.1 - 7.3e-05 23.0 0.0 0.00015 22.0 0.0 1.5 1 0 0 1 1 1 1 TrkA-N domain Polysacc_synt_2 PF02719.15 ADV22211.1 - 0.00036 19.8 0.6 0.002 17.3 0.1 2.3 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein KR PF08659.10 ADV22211.1 - 0.00091 19.2 0.6 0.0067 16.4 0.6 2.3 1 1 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.18 ADV22211.1 - 0.042 14.1 0.3 0.081 13.2 0.3 1.6 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain NAD_binding_3 PF03447.16 ADV22211.1 - 0.16 12.6 0.0 0.27 11.9 0.0 1.3 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain Tim17 PF02466.19 ADV22213.1 - 7.9e-07 29.4 5.8 1.2e-06 28.9 5.3 1.4 1 1 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Alginate_lyase PF05426.12 ADV22214.1 - 9.5e-14 51.6 0.0 1.7e-13 50.7 0.0 1.3 1 1 0 1 1 1 1 Alginate lyase MFS_1 PF07690.16 ADV22215.1 - 3e-29 102.1 26.8 4.1e-29 101.6 26.8 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 ADV22215.1 - 5.6e-05 22.6 17.4 0.00085 18.7 5.2 2.2 2 0 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB Peptidase_S9 PF00326.21 ADV22216.1 - 1.7e-37 129.0 0.0 2.8e-37 128.2 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S9_N PF02897.15 ADV22216.1 - 6.3e-20 71.3 0.0 2e-13 49.9 0.0 2.1 2 0 0 2 2 2 2 Prolyl oligopeptidase, N-terminal beta-propeller domain Glycogen_syn PF05693.13 ADV22218.1 - 0 1093.2 0.0 0 1092.9 0.0 1.0 1 0 0 1 1 1 1 Glycogen synthase Glycos_transf_1 PF00534.20 ADV22218.1 - 1.3e-06 28.1 0.0 0.00017 21.1 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ADV22218.1 - 7.3e-06 26.5 0.0 0.0044 17.4 0.0 2.5 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_transf_5 PF08323.11 ADV22218.1 - 1.1e-05 25.3 0.1 3.1e-05 23.8 0.1 1.8 1 1 0 1 1 1 1 Starch synthase catalytic domain Glyco_transf_4 PF13439.6 ADV22218.1 - 0.00033 20.7 0.3 0.00068 19.7 0.3 1.5 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 ADV22218.1 - 0.00044 20.7 0.2 0.001 19.5 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain DUF3533 PF12051.8 ADV22219.1 - 1.3e-82 277.8 23.6 1.5e-82 277.5 23.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3533) Piwi PF02171.17 ADV22220.1 - 2.2e-82 276.7 0.0 3.4e-82 276.1 0.0 1.3 1 0 0 1 1 1 1 Piwi domain ArgoL2 PF16488.5 ADV22220.1 - 1.8e-12 47.4 0.0 5.4e-12 45.9 0.0 1.9 1 0 0 1 1 1 1 Argonaute linker 2 domain PAZ PF02170.22 ADV22220.1 - 2.3e-12 46.9 0.0 4.9e-12 45.8 0.0 1.5 1 0 0 1 1 1 1 PAZ domain ArgoN PF16486.5 ADV22220.1 - 4.4e-12 46.8 0.3 9.5e-12 45.7 0.3 1.5 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoL1 PF08699.10 ADV22220.1 - 4.5e-09 35.8 0.0 3.6e-08 32.9 0.1 2.4 2 0 0 2 2 2 1 Argonaute linker 1 domain ArgoMid PF16487.5 ADV22220.1 - 2.7e-07 30.8 0.0 8.7e-07 29.1 0.0 1.9 1 0 0 1 1 1 1 Mid domain of argonaute DUF3027 PF11228.8 ADV22221.1 - 0.14 12.2 3.7 3.5 7.6 0.5 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3027) eIF-6 PF01912.18 ADV22222.1 - 7.4e-83 276.8 0.2 7.4e-83 276.8 0.2 1.3 2 0 0 2 2 2 1 eIF-6 family Mob1_phocein PF03637.17 ADV22223.1 - 5.2e-24 85.2 0.0 8.1e-24 84.5 0.0 1.2 1 0 0 1 1 1 1 Mob1/phocein family bZIP_1 PF00170.21 ADV22224.1 - 4.4e-06 26.7 7.3 1.1e-05 25.4 7.3 1.7 1 1 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 ADV22224.1 - 0.16 12.1 11.5 8.7 6.5 11.5 2.3 1 1 0 1 1 1 0 Basic region leucine zipper bZIP_Maf PF03131.17 ADV22224.1 - 0.21 12.1 3.9 0.37 11.3 3.9 1.3 1 0 0 1 1 1 0 bZIP Maf transcription factor FGGY_C PF02782.16 ADV22225.1 - 1.4e-44 152.2 0.0 2e-44 151.7 0.0 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 ADV22225.1 - 1.9e-16 60.4 0.8 4.1e-12 46.2 0.0 3.2 4 0 0 4 4 4 2 FGGY family of carbohydrate kinases, N-terminal domain BcrAD_BadFG PF01869.20 ADV22225.1 - 3.6e-06 26.7 0.1 0.053 13.0 0.0 2.4 2 0 0 2 2 2 2 BadF/BadG/BcrA/BcrD ATPase family RRM_1 PF00076.22 ADV22226.1 - 5.1e-11 42.2 0.0 1.5e-06 27.9 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AA_permease_2 PF13520.6 ADV22227.1 - 3.5e-46 157.9 45.8 4.4e-46 157.6 45.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 ADV22227.1 - 1.4e-26 93.2 43.1 1.9e-26 92.7 43.1 1.0 1 0 0 1 1 1 1 Amino acid permease PGPGW PF09656.10 ADV22227.1 - 0.0024 17.3 1.2 0.014 14.8 1.2 2.4 1 0 0 1 1 1 1 Putative transmembrane protein (PGPGW) Abhydrolase_3 PF07859.13 ADV22228.1 - 3.9e-12 46.5 0.0 5.4e-09 36.2 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Chlorophyllase PF07224.11 ADV22228.1 - 5.1e-07 29.0 0.0 6.9e-07 28.6 0.0 1.1 1 0 0 1 1 1 1 Chlorophyllase DLH PF01738.18 ADV22228.1 - 1.3e-06 28.1 0.0 0.0088 15.6 0.0 2.2 2 0 0 2 2 2 2 Dienelactone hydrolase family Peptidase_S9 PF00326.21 ADV22228.1 - 1.4e-06 28.0 0.0 0.0074 15.8 0.0 2.3 2 0 0 2 2 2 2 Prolyl oligopeptidase family Chlorophyllase2 PF12740.7 ADV22228.1 - 1.4e-05 24.2 0.0 1.9e-05 23.7 0.0 1.1 1 0 0 1 1 1 1 Chlorophyllase enzyme COesterase PF00135.28 ADV22228.1 - 5.6e-05 22.2 0.2 0.00037 19.5 0.2 2.1 2 1 0 2 2 2 1 Carboxylesterase family Hydrolase_4 PF12146.8 ADV22228.1 - 0.00082 18.7 0.0 0.63 9.3 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ADV22228.1 - 0.0014 19.3 0.7 0.0023 18.6 0.7 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.20 ADV22228.1 - 0.013 15.2 0.1 0.054 13.1 0.1 1.9 1 1 0 1 1 1 0 Putative esterase Say1_Mug180 PF10340.9 ADV22228.1 - 0.018 13.9 0.1 0.033 13.0 0.1 1.4 1 1 0 1 1 1 0 Steryl acetyl hydrolase Peptidase_S15 PF02129.18 ADV22228.1 - 0.048 13.2 0.0 1 8.9 0.0 2.6 2 1 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) AXE1 PF05448.12 ADV22228.1 - 0.16 10.6 0.0 0.89 8.2 0.0 1.9 2 0 0 2 2 2 0 Acetyl xylan esterase (AXE1) Lipase_3 PF01764.25 ADV22228.1 - 0.16 11.8 0.0 0.25 11.2 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) BAAT_C PF08840.11 ADV22228.1 - 0.17 11.8 0.0 0.36 10.7 0.0 1.5 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Fungal_trans_2 PF11951.8 ADV22229.1 - 3.1e-33 115.1 0.3 4.2e-33 114.7 0.3 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ADV22229.1 - 0.00014 21.9 10.4 0.00029 20.9 10.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Dickkopf_N PF04706.12 ADV22229.1 - 7.9 7.1 11.5 27 5.3 4.7 2.9 2 1 1 3 3 3 0 Dickkopf N-terminal cysteine-rich region GFO_IDH_MocA PF01408.22 ADV22230.1 - 1.1e-15 58.5 0.0 2.1e-15 57.6 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ADV22230.1 - 2.6e-06 27.4 0.0 4.5e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain Sacchrp_dh_NADP PF03435.18 ADV22230.1 - 0.015 15.6 0.0 0.023 14.9 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain LysR_substrate PF03466.20 ADV22230.1 - 0.13 11.6 0.0 0.23 10.8 0.0 1.4 1 0 0 1 1 1 0 LysR substrate binding domain LuxT_C PF18285.1 ADV22230.1 - 0.17 12.4 0.0 0.47 11.0 0.0 1.7 1 0 0 1 1 1 0 Tetracycline repressor LuxT C-terminal domain Fungal_trans PF04082.18 ADV22231.1 - 1.6e-19 70.0 0.0 3.2e-19 69.0 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ADV22231.1 - 0.00016 21.7 8.5 0.00026 21.1 8.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain LAMTOR PF15454.6 ADV22231.1 - 0.022 15.3 0.0 0.022 15.3 0.0 2.4 2 0 0 2 2 2 0 Late endosomal/lysosomal adaptor and MAPK and MTOR activator Aldedh PF00171.22 ADV22232.1 - 5.5e-180 598.8 0.3 6.2e-180 598.6 0.3 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF5063 PF16702.5 ADV22232.1 - 0.064 13.6 0.0 0.11 12.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5063) Cu_amine_oxid PF01179.20 ADV22233.1 - 1.8e-153 511.4 0.0 2.3e-153 511.0 0.0 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN2 PF02727.16 ADV22233.1 - 7.9e-12 45.2 0.1 2e-11 44.0 0.0 1.7 2 0 0 2 2 2 1 Copper amine oxidase, N2 domain Cu_amine_oxidN3 PF02728.16 ADV22233.1 - 3.1e-11 43.5 0.0 7.9e-11 42.3 0.0 1.7 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain Lipoprotein_21 PF14041.6 ADV22233.1 - 0.15 12.2 0.0 0.32 11.1 0.0 1.5 1 0 0 1 1 1 0 LppP/LprE lipoprotein COPIIcoated_ERV PF07970.12 ADV22234.1 - 4.1e-37 128.2 0.1 6e-37 127.6 0.1 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 ADV22234.1 - 8.8e-23 80.5 0.1 2.5e-22 79.0 0.0 1.8 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) LIAS_N PF16881.5 ADV22235.1 - 1.5e-19 70.4 0.0 3e-19 69.4 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of lipoyl synthase of Radical_SAM family Radical_SAM PF04055.21 ADV22235.1 - 6.4e-11 42.9 0.0 1.1e-10 42.1 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily Spore_GerAC PF05504.11 ADV22235.1 - 0.093 12.9 0.0 0.16 12.2 0.0 1.3 1 0 0 1 1 1 0 Spore germination B3/ GerAC like, C-terminal VIT1 PF01988.19 ADV22236.1 - 0.057 13.3 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 VIT family G_glu_transpept PF01019.21 ADV22237.1 - 1.5e-142 476.0 0.0 4.3e-128 428.3 0.0 2.0 2 0 0 2 2 2 2 Gamma-glutamyltranspeptidase IHHNV_capsid PF16530.5 ADV22237.1 - 0.18 10.9 0.0 0.31 10.1 0.0 1.2 1 0 0 1 1 1 0 Infectious hypodermal and haematopoietic necrosis virus, capsid Aldedh PF00171.22 ADV22238.1 - 1.5e-155 518.2 0.5 1.7e-155 518.0 0.5 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family PTR2 PF00854.21 ADV22239.1 - 3.3e-48 164.5 9.8 4.4e-48 164.1 9.8 1.1 1 0 0 1 1 1 1 POT family 2-oxoacid_dh PF00198.23 ADV22240.1 - 6.5e-81 271.2 0.0 8.2e-81 270.9 0.0 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 ADV22240.1 - 3e-20 71.8 1.3 8.3e-20 70.4 1.3 1.8 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 ADV22240.1 - 8.2e-16 58.1 0.0 1.9e-15 56.9 0.0 1.7 1 0 0 1 1 1 1 e3 binding domain SspB PF04386.13 ADV22240.1 - 2.5 8.0 4.6 8.2 6.3 0.0 2.3 2 0 0 2 2 2 0 Stringent starvation protein B DUF4203 PF13886.6 ADV22242.1 - 2.1e-38 132.0 20.4 3e-38 131.5 20.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4203) Ion_trans PF00520.31 ADV22243.1 - 7.3e-132 438.0 91.6 3.1e-36 124.8 7.9 5.2 5 0 0 5 5 5 5 Ion transport protein GPHH PF16905.5 ADV22243.1 - 0.042 13.6 0.0 0.12 12.2 0.0 1.7 1 0 0 1 1 1 0 Voltage-dependent L-type calcium channel, IQ-associated RdRP_3 PF00998.23 ADV22243.1 - 0.18 10.4 0.1 1.4 7.6 0.1 2.0 2 0 0 2 2 2 0 Viral RNA dependent RNA polymerase GRIP PF01465.20 ADV22245.1 - 7.8e-15 54.5 0.9 1.8e-14 53.4 0.9 1.7 1 0 0 1 1 1 1 GRIP domain DMPK_coil PF08826.10 ADV22245.1 - 0.00038 20.5 2.9 0.00038 20.5 2.9 6.9 7 0 0 7 7 7 1 DMPK coiled coil domain like Septin PF00735.18 ADV22246.1 - 2.1e-111 371.7 0.1 2.6e-111 371.4 0.1 1.0 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 ADV22246.1 - 9e-09 35.4 0.0 1.9e-08 34.4 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 ADV22246.1 - 9.1e-06 25.1 0.0 1.6e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 AIG1 family RsgA_GTPase PF03193.16 ADV22246.1 - 2.2e-05 24.4 0.2 8.9e-05 22.4 0.0 2.0 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 ADV22246.1 - 4.7e-05 23.0 0.1 0.00093 18.8 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 ADV22246.1 - 6.1e-05 23.1 0.2 0.091 12.8 0.1 2.4 2 0 0 2 2 2 2 Dynamin family NB-ARC PF00931.22 ADV22246.1 - 0.00096 18.4 0.0 0.0016 17.7 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain FtsK_SpoIIIE PF01580.18 ADV22246.1 - 0.00099 18.5 0.1 0.0018 17.7 0.1 1.3 1 0 0 1 1 1 1 FtsK/SpoIIIE family AAA_16 PF13191.6 ADV22246.1 - 0.0013 19.1 0.1 0.0038 17.6 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain ABC_tran PF00005.27 ADV22246.1 - 0.0025 18.4 0.0 0.0088 16.6 0.0 1.8 2 0 0 2 2 2 1 ABC transporter AAA_22 PF13401.6 ADV22246.1 - 0.0026 18.1 0.2 0.008 16.5 0.0 2.1 2 1 0 2 2 2 1 AAA domain AAA_7 PF12775.7 ADV22246.1 - 0.011 15.3 0.0 0.029 13.9 0.0 1.7 2 0 0 2 2 2 0 P-loop containing dynein motor region IIGP PF05049.13 ADV22246.1 - 0.021 13.9 1.0 0.034 13.2 0.0 1.9 3 0 0 3 3 3 0 Interferon-inducible GTPase (IIGP) AAA_14 PF13173.6 ADV22246.1 - 0.021 14.9 0.0 0.41 10.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain T2SSE PF00437.20 ADV22246.1 - 0.022 13.8 0.0 0.041 12.9 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein Ras PF00071.22 ADV22246.1 - 0.03 13.9 0.0 0.072 12.7 0.0 1.6 1 0 0 1 1 1 0 Ras family AAA_29 PF13555.6 ADV22246.1 - 0.035 13.9 0.0 0.069 12.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Roc PF08477.13 ADV22246.1 - 0.05 13.8 0.0 0.1 12.8 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 ADV22246.1 - 0.084 12.2 0.2 0.26 10.6 0.0 1.8 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region FeoB_N PF02421.18 ADV22246.1 - 0.66 9.5 2.4 0.72 9.4 0.2 2.2 2 1 0 2 2 2 0 Ferrous iron transport protein B HECT PF00632.25 ADV22249.1 - 6.7e-90 301.7 0.0 1.1e-89 301.0 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) IQ PF00612.27 ADV22249.1 - 0.1 12.4 0.1 0.29 11.0 0.1 1.8 1 0 0 1 1 1 0 IQ calmodulin-binding motif Citrate_bind PF16114.5 ADV22250.1 - 4.3e-87 290.2 0.1 1.1e-86 288.9 0.1 1.7 1 0 0 1 1 1 1 ATP citrate lyase citrate-binding Citrate_synt PF00285.21 ADV22250.1 - 2.8e-15 56.3 0.0 3.6e-12 46.0 0.0 2.8 1 1 1 2 2 2 2 Citrate synthase, C-terminal domain Ligase_CoA PF00549.19 ADV22250.1 - 5.5e-15 55.5 0.0 1.1e-14 54.5 0.0 1.6 1 0 0 1 1 1 1 CoA-ligase CoA_binding PF02629.19 ADV22250.1 - 1.9e-13 50.9 0.0 4.6e-13 49.7 0.0 1.7 1 0 0 1 1 1 1 CoA binding domain Succ_CoA_lig PF13607.6 ADV22250.1 - 3.9e-07 30.0 0.0 2.1e-06 27.6 0.0 2.1 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain ATP-grasp_2 PF08442.10 ADV22250.1 - 1.5e-05 24.7 0.0 2.9e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain Peripla_BP_4 PF13407.6 ADV22250.1 - 0.015 14.9 0.0 1.1 8.8 0.0 2.4 2 0 0 2 2 2 0 Periplasmic binding protein domain Sec2p PF06428.11 ADV22251.1 - 2.8e-21 75.3 5.2 1.7e-20 72.8 5.2 2.4 1 0 0 1 1 1 1 GDP/GTP exchange factor Sec2p Sugar_tr PF00083.24 ADV22252.1 - 2.6e-70 237.5 16.6 4.1e-69 233.6 16.6 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ADV22252.1 - 2.2e-14 53.1 25.9 4.5e-12 45.6 8.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily CTV_P6 PF06706.11 ADV22252.1 - 0.021 14.5 1.3 0.071 12.8 1.3 1.8 1 0 0 1 1 1 0 Citrus tristeza virus 6-kDa protein Fungal_trans PF04082.18 ADV22253.1 - 1.1e-10 41.0 0.0 1.4e-10 40.7 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain ADH_N PF08240.12 ADV22254.1 - 1.1e-28 99.3 2.8 1.6e-28 98.8 2.2 1.6 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ADV22254.1 - 2.4e-18 66.3 0.0 1.1e-17 64.2 0.0 1.9 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 ADV22254.1 - 0.00021 20.8 0.3 0.003 17.1 0.3 2.5 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus Pyr_redox_3 PF13738.6 ADV22254.1 - 0.0029 16.9 0.2 0.0051 16.1 0.2 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase ADH_zinc_N_2 PF13602.6 ADV22254.1 - 0.0032 18.5 0.0 0.0063 17.6 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Pyr_redox_2 PF07992.14 ADV22254.1 - 0.044 13.0 0.5 0.13 11.5 0.1 1.8 1 1 1 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 ADV22254.1 - 0.068 12.2 0.1 0.096 11.7 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain PALP PF00291.25 ADV22254.1 - 0.073 12.5 0.2 0.1 12.0 0.2 1.2 1 0 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme FAD_binding_3 PF01494.19 ADV22254.1 - 0.097 11.9 0.0 0.16 11.2 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain 2-Hacid_dh_C PF02826.19 ADV22254.1 - 0.15 11.4 0.0 0.26 10.6 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Sugar_tr PF00083.24 ADV22255.1 - 3.4e-91 306.4 15.7 4.5e-91 306.0 15.7 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ADV22255.1 - 1.7e-25 89.7 15.7 1.7e-25 89.7 15.7 1.8 2 0 0 2 2 2 1 Major Facilitator Superfamily cobW PF02492.19 ADV22257.1 - 3.4e-46 157.0 3.8 2e-35 122.0 0.9 2.3 1 1 1 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 ADV22257.1 - 4.5e-16 58.5 0.0 1.1e-10 41.2 0.0 2.6 2 0 0 2 2 2 2 Cobalamin synthesis protein cobW C-terminal domain MeaB PF03308.16 ADV22257.1 - 0.0044 16.0 0.1 0.022 13.7 0.0 2.1 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_18 PF13238.6 ADV22257.1 - 0.022 15.3 1.1 0.051 14.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain T2SSE PF00437.20 ADV22257.1 - 0.056 12.5 0.0 0.09 11.8 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein GTP_EFTU PF00009.27 ADV22257.1 - 0.07 12.7 0.2 1.4 8.4 0.0 2.4 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 ADV22257.1 - 0.077 13.4 0.2 0.27 11.6 0.2 2.1 1 1 0 1 1 1 0 AAA ATPase domain MobB PF03205.14 ADV22257.1 - 0.078 12.9 0.0 0.18 11.7 0.0 1.7 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B TsaE PF02367.17 ADV22257.1 - 0.14 12.1 0.0 0.33 10.9 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Pribosyltran PF00156.27 ADV22258.1 - 8.5e-05 22.1 0.0 0.00014 21.4 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Pyrophosphatase PF00719.19 ADV22259.1 - 4.3e-59 198.9 0.1 6.2e-59 198.4 0.1 1.2 1 0 0 1 1 1 1 Inorganic pyrophosphatase TatD_DNase PF01026.21 ADV22260.1 - 7.4e-18 64.8 0.0 1e-17 64.4 0.0 1.2 1 0 0 1 1 1 1 TatD related DNase Ank_2 PF12796.7 ADV22261.1 - 1.6e-43 147.2 0.0 3.3e-15 56.4 0.0 4.3 2 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ADV22261.1 - 9.6e-33 112.2 0.2 1.4e-09 38.3 0.0 4.7 4 0 0 4 4 4 4 Ankyrin repeats (many copies) SPX PF03105.19 ADV22261.1 - 9.2e-28 98.2 5.4 1.2e-17 64.9 1.0 2.9 2 1 0 2 2 2 2 SPX domain Ank_3 PF13606.6 ADV22261.1 - 5e-23 78.7 0.4 0.025 15.1 0.0 7.0 6 0 0 6 6 6 6 Ankyrin repeat Ank_5 PF13857.6 ADV22261.1 - 7.4e-23 80.3 2.0 0.0013 19.0 0.0 7.4 3 2 4 7 7 7 6 Ankyrin repeats (many copies) Ank PF00023.30 ADV22261.1 - 4.2e-20 71.2 1.8 0.0041 17.5 0.0 7.0 7 0 0 7 7 7 4 Ankyrin repeat GDPD PF03009.17 ADV22261.1 - 6.9e-13 48.9 0.0 1.1e-08 35.2 0.0 2.4 2 0 0 2 2 2 2 Glycerophosphoryl diester phosphodiesterase family DUF3324 PF11797.8 ADV22262.1 - 0.1 12.6 0.0 0.11 12.5 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function C-terminal (DUF3324) AA_permease PF00324.21 ADV22263.1 - 6.4e-138 460.3 42.7 7.9e-138 460.0 42.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 ADV22263.1 - 3e-44 151.5 47.6 3.7e-44 151.2 47.6 1.1 1 0 0 1 1 1 1 Amino acid permease DinB PF05163.12 ADV22264.1 - 0.02 14.8 2.1 0.023 14.6 1.6 1.4 1 1 0 1 1 1 0 DinB family Ist1 PF03398.14 ADV22265.1 - 2.9e-56 189.9 0.0 3.9e-56 189.5 0.0 1.2 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway DAO PF01266.24 ADV22267.1 - 3.9e-33 115.5 0.6 4.4e-33 115.3 0.6 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 ADV22267.1 - 0.0017 17.5 0.0 0.0025 17.0 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 ADV22267.1 - 0.028 13.7 0.1 0.32 10.2 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 ADV22267.1 - 0.13 12.1 0.0 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_binding_3 PF01494.19 ADV22267.1 - 0.21 10.8 0.1 0.34 10.1 0.1 1.3 1 0 0 1 1 1 0 FAD binding domain Thi4 PF01946.17 ADV22267.1 - 0.21 10.8 0.7 0.35 10.1 0.1 1.7 2 0 0 2 2 2 0 Thi4 family Pkinase PF00069.25 ADV22268.1 - 2e-63 214.2 0.0 2.4e-63 214.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV22268.1 - 1.4e-28 99.9 0.0 2e-28 99.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ADV22268.1 - 1.8e-05 24.2 0.0 3e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ADV22268.1 - 2.6e-05 23.7 0.0 3.9e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 ADV22268.1 - 0.0009 19.2 0.2 0.48 10.3 0.1 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ADV22268.1 - 0.0014 17.6 0.0 0.002 17.1 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 ADV22268.1 - 0.0047 16.5 0.0 0.0086 15.7 0.0 1.4 1 0 0 1 1 1 1 RIO1 family Fip1 PF05182.13 ADV22269.1 - 2e-15 56.0 0.2 3.4e-15 55.3 0.2 1.4 1 0 0 1 1 1 1 Fip1 motif DUF5521 PF17659.1 ADV22270.1 - 1.8 6.3 2.8 2.8 5.7 2.8 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5521) DUF1708 PF08101.11 ADV22271.1 - 3.6e-19 69.2 0.2 1.7e-18 67.0 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF1708) RhoGAP PF00620.27 ADV22271.1 - 7.6e-05 22.6 0.0 0.00016 21.5 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain Mito_carr PF00153.27 ADV22272.1 - 1.2e-62 207.8 2.4 5.4e-21 74.3 0.0 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein Fis1_TPR_C PF14853.6 ADV22273.1 - 1.2e-23 82.9 0.5 1.7e-23 82.4 0.5 1.3 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat COPI_C PF06957.11 ADV22273.1 - 0.16 10.7 0.0 0.21 10.3 0.0 1.1 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus HLH PF00010.26 ADV22274.1 - 1.1e-13 50.9 0.1 2.6e-13 49.7 0.1 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Spo7 PF03907.13 ADV22275.1 - 5.7e-35 120.8 2.5 1.9e-34 119.1 2.5 1.7 1 1 0 1 1 1 1 Spo7-like protein Tmemb_18A PF09771.9 ADV22275.1 - 0.014 15.8 0.3 0.014 15.8 0.3 1.6 2 0 0 2 2 2 0 Transmembrane protein 188 DUF5345 PF17280.2 ADV22275.1 - 0.044 13.7 0.4 0.098 12.6 0.2 1.7 1 1 0 1 1 1 0 Family of unknown function (DUF5345) LysM PF01476.20 ADV22276.1 - 0.0067 16.5 0.0 0.015 15.4 0.0 1.5 1 0 0 1 1 1 1 LysM domain SNF2_N PF00176.23 ADV22277.1 - 2.8e-54 184.2 0.0 3.1e-53 180.7 0.0 2.2 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ADV22277.1 - 6.5e-10 39.3 0.0 3.2e-09 37.1 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain zf-C3HC4_2 PF13923.6 ADV22277.1 - 8.3e-07 28.8 6.1 8.3e-07 28.8 6.1 3.4 2 1 1 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ADV22277.1 - 1.6e-06 27.9 6.4 1.6e-06 27.9 6.4 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) ResIII PF04851.15 ADV22277.1 - 8.4e-06 25.9 0.0 1.9e-05 24.7 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit zf-C3HC4_3 PF13920.6 ADV22277.1 - 1.3e-05 24.9 5.8 1.3e-05 24.9 5.8 2.4 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ADV22277.1 - 2e-05 24.8 6.3 2e-05 24.8 6.3 3.1 2 1 0 2 2 1 1 Ring finger domain zf-rbx1 PF12678.7 ADV22277.1 - 0.0001 22.5 3.3 0.00034 20.8 3.3 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-Nse PF11789.8 ADV22277.1 - 0.0012 18.7 4.0 0.0036 17.1 4.0 1.8 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-ANAPC11 PF12861.7 ADV22277.1 - 0.0013 18.7 1.0 0.0013 18.7 1.0 2.0 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 ADV22277.1 - 0.0015 18.3 5.3 0.0015 18.3 5.3 2.4 2 0 0 2 2 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 ADV22277.1 - 0.0017 18.3 5.2 0.0017 18.3 5.2 2.8 2 0 0 2 2 2 1 RING-type zinc-finger DEAD PF00270.29 ADV22277.1 - 0.0034 17.2 0.0 0.0077 16.0 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase zf-RING_5 PF14634.6 ADV22277.1 - 1.6 8.8 22.2 0.031 14.2 6.4 2.5 2 0 0 2 2 2 0 zinc-RING finger domain zf-RING_11 PF17123.5 ADV22277.1 - 4.4 7.1 9.7 0.11 12.3 1.5 2.7 3 0 0 3 3 3 0 RING-like zinc finger Pkinase PF00069.25 ADV22278.1 - 7e-66 222.3 0.0 8.3e-66 222.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV22278.1 - 1.6e-31 109.6 0.0 2.4e-31 108.9 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ADV22278.1 - 0.00031 20.2 0.2 0.00072 19.0 0.1 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ADV22278.1 - 0.0022 17.3 0.0 0.0032 16.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 ADV22278.1 - 0.0083 15.1 0.3 0.029 13.3 0.4 1.6 1 1 0 1 1 1 1 Haspin like kinase domain Phage_sheath_1C PF17482.2 ADV22278.1 - 0.024 14.6 0.0 0.049 13.6 0.0 1.6 1 0 0 1 1 1 0 Phage tail sheath C-terminal domain APH PF01636.23 ADV22278.1 - 0.025 14.5 0.6 1.3 8.9 0.1 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family TFIIA PF03153.13 ADV22279.1 - 0.00072 19.7 28.0 0.00098 19.2 28.0 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit SKG6 PF08693.10 ADV22279.1 - 0.0052 16.2 3.4 0.011 15.1 3.4 1.6 1 0 0 1 1 1 1 Transmembrane alpha-helix domain EphA2_TM PF14575.6 ADV22279.1 - 0.0053 17.6 0.2 0.033 15.1 0.0 2.5 2 0 0 2 2 2 1 Ephrin type-A receptor 2 transmembrane domain OppC_N PF12911.7 ADV22279.1 - 0.029 14.3 0.8 0.077 13.0 0.8 1.7 1 0 0 1 1 1 0 N-terminal TM domain of oligopeptide transport permease C FAM176 PF14851.6 ADV22279.1 - 0.23 11.1 0.0 0.23 11.1 0.0 2.7 3 1 0 3 3 3 0 FAM176 family Adeno_E3_CR2 PF02439.15 ADV22279.1 - 0.29 10.9 1.0 0.46 10.3 1.0 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Shisa PF13908.6 ADV22279.1 - 0.69 10.1 0.0 0.69 10.1 0.0 5.2 1 1 3 4 4 4 0 Wnt and FGF inhibitory regulator Adeno_E3 PF06040.11 ADV22279.1 - 4.9 7.4 6.4 1.6 8.9 1.4 2.4 1 1 0 2 2 2 0 Adenovirus E3 protein Acetyltransf_3 PF13302.7 ADV22281.1 - 1.1e-13 52.0 0.0 1.7e-13 51.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ADV22281.1 - 6.8e-06 26.3 0.0 9.6e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ADV22281.1 - 0.1 13.1 0.0 0.15 12.5 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Abhydrolase_1 PF00561.20 ADV22282.1 - 9e-24 84.5 0.0 4.2e-23 82.3 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ADV22282.1 - 4.5e-15 55.6 0.0 9.2e-10 38.2 0.0 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ADV22282.1 - 5.1e-15 56.7 5.1 5.1e-15 56.7 5.1 2.7 2 1 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 ADV22282.1 - 2.7e-05 24.1 0.2 0.0025 17.7 0.0 2.7 3 0 0 3 3 3 1 alpha/beta hydrolase fold Esterase PF00756.20 ADV22282.1 - 0.00014 21.6 0.0 0.00026 20.7 0.0 1.4 1 0 0 1 1 1 1 Putative esterase Ser_hydrolase PF06821.13 ADV22282.1 - 0.00024 21.0 0.0 0.00073 19.4 0.0 1.8 1 0 0 1 1 1 1 Serine hydrolase BAAT_C PF08840.11 ADV22282.1 - 0.00044 20.2 0.0 1.2 9.1 0.0 2.4 2 0 0 2 2 2 2 BAAT / Acyl-CoA thioester hydrolase C terminal Ndr PF03096.14 ADV22282.1 - 0.00051 18.8 0.0 0.0011 17.8 0.0 1.5 1 0 0 1 1 1 1 Ndr family Peptidase_S9 PF00326.21 ADV22282.1 - 0.00079 19.0 0.1 1.3 8.4 0.0 2.3 2 0 0 2 2 2 2 Prolyl oligopeptidase family DLH PF01738.18 ADV22282.1 - 0.0011 18.6 0.0 0.15 11.6 0.0 2.4 2 0 0 2 2 2 1 Dienelactone hydrolase family LIDHydrolase PF10230.9 ADV22282.1 - 0.002 17.7 0.0 0.0036 16.9 0.0 1.3 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Abhydrolase_5 PF12695.7 ADV22282.1 - 0.0051 16.6 0.0 0.01 15.6 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Lipase_3 PF01764.25 ADV22282.1 - 0.0099 15.7 0.0 0.018 14.9 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) UPF0227 PF05728.12 ADV22282.1 - 0.018 15.0 0.0 0.032 14.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) Acyl_transf_1 PF00698.21 ADV22282.1 - 0.15 11.5 0.0 0.23 10.9 0.0 1.2 1 0 0 1 1 1 0 Acyl transferase domain Chlorophyllase2 PF12740.7 ADV22282.1 - 0.15 10.9 0.0 0.43 9.5 0.0 1.7 2 0 0 2 2 2 0 Chlorophyllase enzyme PGAP1 PF07819.13 ADV22282.1 - 0.16 11.7 0.0 0.28 10.9 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein DUF2048 PF09752.9 ADV22282.1 - 0.16 11.0 0.0 0.26 10.3 0.0 1.2 1 0 0 1 1 1 0 Abhydrolase domain containing 18 Calreticulin PF00262.18 ADV22283.1 - 3.8e-165 549.2 8.1 4.8e-165 548.9 8.1 1.1 1 0 0 1 1 1 1 Calreticulin family DUF883 PF05957.13 ADV22283.1 - 0.01 16.4 0.1 0.023 15.3 0.1 1.6 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) Phage_holin_3_6 PF07332.11 ADV22283.1 - 7.3 6.7 7.5 0.27 11.3 1.1 1.7 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III DSBA PF01323.20 ADV22285.1 - 2e-23 83.2 0.0 2.4e-23 82.9 0.0 1.0 1 0 0 1 1 1 1 DSBA-like thioredoxin domain Thioredoxin_2 PF13098.6 ADV22285.1 - 0.0044 17.5 0.0 0.023 15.1 0.0 2.0 2 0 0 2 2 2 1 Thioredoxin-like domain NADH_4Fe-4S PF10589.9 ADV22285.1 - 0.013 15.6 0.0 10 6.3 0.0 2.9 3 0 0 3 3 3 0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region Thioredoxin_3 PF13192.6 ADV22285.1 - 0.041 13.9 0.0 0.11 12.5 0.0 1.7 2 0 0 2 2 2 0 Thioredoxin domain Peptidase_S10 PF00450.22 ADV22286.1 - 5.5e-93 312.6 0.0 7.2e-93 312.3 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Gram_pos_anchor PF00746.21 ADV22286.1 - 0.12 12.4 0.3 0.31 11.0 0.3 1.7 1 0 0 1 1 1 0 LPXTG cell wall anchor motif Pro_isomerase PF00160.21 ADV22287.1 - 3.1e-49 167.3 0.0 3.6e-49 167.1 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Mre11_DNA_bind PF04152.14 ADV22288.1 - 4.7e-49 167.0 3.6 4.7e-49 167.0 3.6 1.9 2 0 0 2 2 2 1 Mre11 DNA-binding presumed domain Metallophos PF00149.28 ADV22288.1 - 7.6e-13 49.4 0.3 1.6e-12 48.4 0.3 1.6 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ADV22288.1 - 1.2e-06 28.8 0.0 3.8e-05 23.9 0.0 2.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain PBP1_TM PF14812.6 ADV22288.1 - 0.0088 16.4 7.9 0.0088 16.4 7.9 3.5 2 1 2 4 4 4 1 Transmembrane domain of transglycosylase PBP1 at N-terminal FRB_dom PF08771.11 ADV22288.1 - 0.015 15.7 0.3 0.14 12.6 0.1 2.2 2 0 0 2 2 2 0 FKBP12-rapamycin binding domain DUF3333 PF11812.8 ADV22288.1 - 0.24 11.6 1.7 0.46 10.7 1.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3333) ECH_1 PF00378.20 ADV22289.1 - 7.8e-07 28.7 0.1 2e-06 27.3 0.1 1.6 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase ATP-synt PF00231.19 ADV22290.1 - 1.6e-75 254.4 5.5 1.9e-75 254.2 5.5 1.0 1 0 0 1 1 1 1 ATP synthase DUF4127 PF13552.6 ADV22290.1 - 0.045 12.4 2.1 0.27 9.8 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4127) DUF695 PF05117.12 ADV22290.1 - 0.2 11.8 0.6 7.5 6.7 0.0 2.6 3 0 0 3 3 3 0 Family of unknown function (DUF695) Pro_isomerase PF00160.21 ADV22291.1 - 4.5e-45 153.8 0.1 5.2e-45 153.6 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD eIF-5_eIF-2B PF01873.17 ADV22292.1 - 9.9e-41 138.3 0.3 1.7e-40 137.6 0.3 1.3 1 0 0 1 1 1 1 Domain found in IF2B/IF5 TF_Zn_Ribbon PF08271.12 ADV22292.1 - 8.1e-05 22.1 0.2 0.00015 21.2 0.2 1.5 1 0 0 1 1 1 1 TFIIB zinc-binding Vma12 PF11712.8 ADV22292.1 - 0.11 12.5 3.7 0.17 11.9 0.2 2.7 2 1 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Herpes_BLLF1 PF05109.13 ADV22292.1 - 1.9 6.3 7.9 2.7 5.8 7.9 1.1 1 0 0 1 1 1 0 Herpes virus major outer envelope glycoprotein (BLLF1) PTPLA PF04387.14 ADV22293.1 - 8.4e-57 191.5 5.9 1.3e-56 190.8 5.9 1.3 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA ADH_zinc_N PF00107.26 ADV22294.1 - 9.6e-29 100.0 1.7 1.7e-28 99.2 1.7 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ADV22294.1 - 2.3e-26 91.8 1.1 2.3e-26 91.8 1.1 1.8 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 ADV22294.1 - 8.9e-09 36.5 0.4 1.6e-08 35.7 0.4 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 ADV22294.1 - 0.025 13.9 1.4 0.044 13.1 1.0 1.6 1 1 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Nse4_C PF08743.10 ADV22295.1 - 7.1e-26 90.3 0.0 2.3e-25 88.7 0.0 1.9 1 0 0 1 1 1 1 Nse4 C-terminal Nse4-Nse3_bdg PF15412.6 ADV22295.1 - 2.2e-12 46.9 1.2 5.2e-11 42.5 0.9 2.5 2 0 0 2 2 2 1 Binding domain of Nse4/EID3 to Nse3-MAGE CENP-F_N PF10481.9 ADV22295.1 - 0.01 15.5 2.2 0.054 13.1 0.9 2.1 2 0 0 2 2 2 1 Cenp-F N-terminal domain DUF4140 PF13600.6 ADV22295.1 - 1.6 9.2 6.7 45 4.6 5.2 3.1 3 2 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) CPSF100_C PF13299.6 ADV22295.1 - 2.8 8.1 6.3 0.37 11.0 0.3 2.4 1 1 1 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal RTA1 PF04479.13 ADV22296.1 - 4.4e-58 196.3 2.9 4.4e-58 196.3 2.9 2.2 2 1 0 2 2 2 1 RTA1 like protein Methyltransf_34 PF11312.8 ADV22297.1 - 2.6e-79 266.7 0.0 3.2e-79 266.4 0.0 1.1 1 0 0 1 1 1 1 Putative SAM-dependent methyltransferase DDHD PF02862.17 ADV22297.1 - 0.0095 16.1 0.0 0.014 15.6 0.0 1.2 1 0 0 1 1 1 1 DDHD domain SNAD2 PF18745.1 ADV22297.1 - 0.026 14.2 0.0 0.042 13.6 0.0 1.2 1 0 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 2 Thaumatin PF00314.17 ADV22298.1 - 5.5e-55 186.3 11.1 7.9e-55 185.8 11.1 1.2 1 0 0 1 1 1 1 Thaumatin family Lgl_C PF08596.10 ADV22299.1 - 7e-112 374.0 0.0 1e-111 373.4 0.0 1.2 1 0 0 1 1 1 1 Lethal giant larvae(Lgl) like, C-terminal WD40 PF00400.32 ADV22299.1 - 0.0013 19.5 4.4 10 7.2 0.3 5.3 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV22299.1 - 0.0071 16.6 0.0 0.54 10.6 0.0 3.8 4 0 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain IPP-2 PF04979.14 ADV22300.1 - 3.3e-17 63.5 11.1 2.7e-16 60.5 11.1 2.1 1 1 0 1 1 1 1 Protein phosphatase inhibitor 2 (IPP-2) DUF1697 PF08002.11 ADV22300.1 - 0.12 12.9 0.2 0.19 12.2 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1697) Pox_Ag35 PF03286.14 ADV22300.1 - 0.15 11.9 11.6 0.43 10.4 0.5 2.3 2 0 0 2 2 2 0 Pox virus Ag35 surface protein DEAD PF00270.29 ADV22301.1 - 1.5e-47 161.6 0.0 1.2e-46 158.7 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ADV22301.1 - 5.3e-29 100.8 0.0 7.6e-27 93.9 0.0 2.8 2 1 1 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 ADV22301.1 - 0.00031 20.8 0.1 0.0018 18.3 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Pkinase_fungal PF17667.1 ADV22301.1 - 0.022 13.5 2.8 0.033 13.0 2.8 1.2 1 0 0 1 1 1 0 Fungal protein kinase ERCC3_RAD25_C PF16203.5 ADV22301.1 - 0.047 12.9 0.0 0.047 12.9 0.0 2.1 2 1 0 2 2 2 0 ERCC3/RAD25/XPB C-terminal helicase TFIIF_alpha PF05793.12 ADV22301.1 - 0.056 12.0 19.9 0.079 11.5 19.9 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Glypican PF01153.19 ADV22301.1 - 4 6.2 5.3 5.9 5.6 5.3 1.1 1 0 0 1 1 1 0 Glypican GREB1 PF15782.5 ADV22301.1 - 5.7 3.9 10.2 7.2 3.6 10.2 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer GSHPx PF00255.19 ADV22302.1 - 1.4e-37 127.6 0.0 1.8e-37 127.2 0.0 1.2 1 0 0 1 1 1 1 Glutathione peroxidase Erf4 PF10256.9 ADV22303.1 - 9.8e-26 90.1 0.1 1.4e-25 89.6 0.1 1.2 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family DHBP_synthase PF00926.19 ADV22304.1 - 6.3e-74 247.7 0.0 7.2e-74 247.5 0.0 1.0 1 0 0 1 1 1 1 3,4-dihydroxy-2-butanone 4-phosphate synthase JAB PF01398.21 ADV22305.1 - 0.0035 17.3 0.0 0.0073 16.3 0.0 1.6 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease D123 PF07065.14 ADV22305.1 - 0.17 11.0 0.0 0.25 10.5 0.0 1.1 1 0 0 1 1 1 0 D123 RPN7 PF10602.9 ADV22307.1 - 4.4e-40 137.2 0.0 6.5e-40 136.7 0.0 1.2 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 ADV22307.1 - 2.6e-09 37.5 0.0 5.4e-09 36.5 0.0 1.6 1 0 0 1 1 1 1 PCI domain TPR_16 PF13432.6 ADV22307.1 - 0.0016 19.0 2.9 0.064 13.9 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat RNA_pol_Rpc4 PF05132.14 ADV22308.1 - 1.2e-21 77.7 7.5 1.2e-21 77.7 7.5 3.9 3 2 0 3 3 3 1 RNA polymerase III RPC4 BUD22 PF09073.10 ADV22308.1 - 0.015 14.6 10.8 0.021 14.2 10.8 1.1 1 0 0 1 1 1 0 BUD22 DUF2985 PF11204.8 ADV22309.1 - 1.4e-30 105.2 1.1 2.7e-30 104.3 1.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2985) MFS_1 PF07690.16 ADV22311.1 - 1.2e-27 96.8 16.7 1.2e-27 96.8 16.7 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily EI24 PF07264.11 ADV22311.1 - 0.12 12.6 17.2 0.03 14.6 4.5 2.4 2 0 0 2 2 2 0 Etoposide-induced protein 2.4 (EI24) Complex1_LYR PF05347.15 ADV22312.1 - 0.06 13.4 1.3 0.12 12.4 0.2 1.9 2 0 0 2 2 2 0 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 ADV22312.1 - 0.061 14.1 0.4 0.072 13.9 0.4 1.2 1 0 0 1 1 1 0 Complex1_LYR-like PTS_2-RNA PF01885.16 ADV22313.1 - 5.2e-52 176.5 0.0 6.8e-52 176.2 0.0 1.1 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family TAF PF02969.17 ADV22314.1 - 5.1e-19 68.2 0.0 1.4e-18 66.8 0.0 1.8 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) TAF6_C PF07571.13 ADV22314.1 - 1.9e-12 47.3 0.0 4.5e-12 46.1 0.0 1.5 1 0 0 1 1 1 1 TAF6 C-terminal HEAT repeat domain Histone PF00125.24 ADV22314.1 - 7.9e-05 23.0 0.0 0.0002 21.7 0.0 1.7 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 ADV22314.1 - 0.027 14.7 0.0 0.059 13.7 0.0 1.5 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Frag1 PF10277.9 ADV22315.1 - 2.2e-32 112.4 6.9 2.6e-32 112.1 6.9 1.0 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family DsbD PF02683.15 ADV22315.1 - 0.0023 17.9 0.4 0.0046 16.9 0.4 1.6 1 1 0 1 1 1 1 Cytochrome C biogenesis protein transmembrane region PIG-Y PF15159.6 ADV22315.1 - 0.047 14.6 6.8 1.4 9.9 1.2 3.3 3 0 0 3 3 3 0 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y Oxidored_q3 PF00499.20 ADV22315.1 - 4.2 7.1 7.0 0.23 11.2 0.6 2.2 2 2 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 MFS_1 PF07690.16 ADV22316.1 - 1.4e-26 93.3 25.1 3.2e-26 92.1 24.4 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily UNC-93 PF05978.16 ADV22316.1 - 0.064 13.0 3.7 0.14 11.9 3.7 1.6 1 0 0 1 1 1 0 Ion channel regulatory protein UNC-93 Trp_oprn_chp PF09534.10 ADV22316.1 - 2.4 7.9 8.7 7 6.4 0.4 2.8 3 0 0 3 3 3 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Fructosamin_kin PF03881.14 ADV22317.1 - 7.3e-67 225.6 0.0 9.2e-67 225.3 0.0 1.0 1 0 0 1 1 1 1 Fructosamine kinase APH PF01636.23 ADV22317.1 - 0.0052 16.7 0.0 0.0087 16.0 0.0 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family Swi5 PF07061.11 ADV22318.1 - 1.3e-17 63.6 0.7 1.7e-17 63.3 0.7 1.1 1 0 0 1 1 1 1 Swi5 Nup192 PF11894.8 ADV22319.1 - 6.2e-291 968.5 0.0 8e-291 968.1 0.0 1.1 1 0 0 1 1 1 1 Nuclear pore complex scaffold, nucleoporins 186/192/205 DNA_ligase_A_M PF01068.21 ADV22320.1 - 3.6e-08 33.3 0.0 1.1e-07 31.7 0.0 1.9 1 1 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_OB_2 PF14743.6 ADV22320.1 - 3e-07 30.4 0.0 6.5e-07 29.3 0.0 1.5 1 0 0 1 1 1 1 DNA ligase OB-like domain FMN_dh PF01070.18 ADV22320.1 - 0.0035 16.4 0.0 0.0053 15.8 0.0 1.2 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Alpha-amylase PF00128.24 ADV22324.1 - 1.3e-105 353.7 0.0 1.7e-105 353.3 0.0 1.1 1 0 0 1 1 1 1 Alpha amylase, catalytic domain hDGE_amylase PF14701.6 ADV22324.1 - 0.0032 16.6 0.0 0.0052 15.9 0.0 1.2 1 0 0 1 1 1 1 Glycogen debranching enzyme, glucanotransferase domain Rad9 PF04139.13 ADV22325.1 - 6.8e-94 314.0 0.0 8.9e-94 313.6 0.0 1.1 1 0 0 1 1 1 1 Rad9 HTH_50 PF18024.1 ADV22325.1 - 0.0085 15.7 0.0 0.021 14.4 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain Sugar_tr PF00083.24 ADV22326.1 - 3.2e-111 372.4 15.8 8.3e-111 371.0 15.8 1.6 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ADV22326.1 - 7.8e-33 113.8 50.5 1.8e-30 106.1 24.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily PagP PF07017.11 ADV22326.1 - 0.16 11.4 0.1 0.28 10.6 0.1 1.3 1 0 0 1 1 1 0 Antimicrobial peptide resistance and lipid A acylation protein PagP Amastin PF07344.11 ADV22326.1 - 0.17 11.7 3.7 0.38 10.6 0.5 2.5 2 0 0 2 2 2 0 Amastin surface glycoprotein DUF3180 PF11377.8 ADV22326.1 - 0.3 11.2 0.0 0.3 11.2 0.0 3.5 2 2 0 4 4 4 0 Protein of unknown function (DUF3180) Aldo_ket_red PF00248.21 ADV22327.1 - 3.6e-51 174.1 0.0 2e-49 168.4 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family Lactonase PF10282.9 ADV22328.1 - 5.8e-25 88.3 0.0 3.4e-14 52.9 0.0 2.1 2 0 0 2 2 2 2 Lactonase, 7-bladed beta-propeller Gmad1 PF10647.9 ADV22328.1 - 0.064 13.0 0.0 0.091 12.5 0.0 1.2 1 0 0 1 1 1 0 Lipoprotein LpqB beta-propeller domain Fungal_trans PF04082.18 ADV22329.1 - 4e-13 49.0 0.1 9.3e-13 47.8 0.1 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ADV22329.1 - 0.00064 19.8 14.9 0.0013 18.8 14.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain GFO_IDH_MocA PF01408.22 ADV22330.1 - 3.5e-21 76.3 0.2 9.4e-20 71.6 0.1 2.2 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ADV22330.1 - 5.8e-06 26.3 0.0 1.5e-05 25.0 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain NAD_binding_7 PF13241.6 ADV22330.1 - 0.0023 18.4 0.0 0.0061 17.0 0.0 1.8 1 1 0 1 1 1 1 Putative NAD(P)-binding 2-Hacid_dh_C PF02826.19 ADV22330.1 - 0.075 12.4 0.0 0.18 11.2 0.0 1.6 1 1 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_10 PF13460.6 ADV22331.1 - 3.3e-06 27.1 0.0 4.9e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding HIM1 PF08732.10 ADV22331.1 - 2.6e-05 23.8 0.0 3.6e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 HIM1 Semialdhyde_dh PF01118.24 ADV22331.1 - 0.002 18.5 0.0 0.0067 16.9 0.0 1.8 1 1 1 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain NmrA PF05368.13 ADV22331.1 - 0.12 11.9 0.0 0.25 10.9 0.0 1.9 1 1 0 1 1 1 0 NmrA-like family IF3_C PF00707.22 ADV22332.1 - 0.00011 22.1 0.2 0.00019 21.3 0.2 1.4 1 0 0 1 1 1 1 Translation initiation factor IF-3, C-terminal domain mIF3 PF14877.6 ADV22332.1 - 0.0012 18.5 2.4 0.0084 15.8 2.9 1.8 1 1 1 2 2 2 1 Mitochondrial translation initiation factor IF3_N PF05198.16 ADV22332.1 - 0.0013 19.0 0.0 0.0024 18.1 0.0 1.4 1 0 0 1 1 1 1 Translation initiation factor IF-3, N-terminal domain cobW PF02492.19 ADV22333.1 - 4.6e-43 146.9 0.1 6.1e-43 146.5 0.1 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 ADV22333.1 - 1e-06 28.6 0.0 1.7e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain RsgA_GTPase PF03193.16 ADV22333.1 - 0.00012 22.0 0.1 0.35 10.8 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 ADV22333.1 - 0.00045 19.8 0.1 0.02 14.4 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ADV22333.1 - 0.00049 20.2 0.0 0.00098 19.2 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_29 PF13555.6 ADV22333.1 - 0.001 18.7 0.0 0.0023 17.6 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 ADV22333.1 - 0.012 16.1 0.0 0.027 15.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain MeaB PF03308.16 ADV22333.1 - 0.014 14.4 0.7 1.3 8.0 0.0 2.4 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_16 PF13191.6 ADV22333.1 - 0.018 15.4 0.0 0.058 13.8 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain Arf PF00025.21 ADV22333.1 - 0.03 13.8 0.5 0.25 10.8 0.1 2.2 2 0 0 2 2 2 0 ADP-ribosylation factor family TsaE PF02367.17 ADV22333.1 - 0.07 13.1 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 ADV22333.1 - 0.12 13.0 0.0 0.37 11.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 ADV22333.1 - 0.13 12.8 0.1 0.32 11.5 0.0 1.6 2 0 0 2 2 2 0 ABC transporter AAA_22 PF13401.6 ADV22333.1 - 0.13 12.5 0.0 0.33 11.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 ADV22333.1 - 0.17 12.0 0.0 1.5 9.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain MMS19_N PF14500.6 ADV22334.1 - 2.1e-91 306.1 0.7 2.5e-89 299.4 0.1 4.0 4 1 1 5 5 5 1 Dos2-interacting transcription regulator of RNA-Pol-II MMS19_C PF12460.8 ADV22334.1 - 5.1e-88 296.0 0.1 2.5e-86 290.4 0.0 2.9 3 0 0 3 3 3 1 RNAPII transcription regulator C-terminal HEAT_2 PF13646.6 ADV22334.1 - 2.8e-06 27.6 0.7 0.14 12.5 0.1 5.0 4 1 1 5 5 5 2 HEAT repeats Cnd1 PF12717.7 ADV22334.1 - 0.0039 17.3 0.1 5.3 7.1 0.1 3.5 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 ADV22334.1 - 0.0058 16.8 0.9 33 5.1 0.0 5.2 6 0 0 6 6 6 0 HEAT repeat HEAT_EZ PF13513.6 ADV22334.1 - 0.0067 16.9 4.7 0.27 11.8 0.1 5.0 6 0 0 6 6 6 1 HEAT-like repeat UNC45-central PF11701.8 ADV22334.1 - 0.24 11.3 3.0 11 6.0 0.0 3.9 4 1 0 4 4 4 0 Myosin-binding striated muscle assembly central SMC_N PF02463.19 ADV22335.1 - 1.6e-75 253.3 0.8 3.9e-75 252.1 0.8 1.7 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 ADV22335.1 - 2e-23 82.9 0.0 6.7e-23 81.2 0.0 2.0 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 ADV22335.1 - 4.8e-13 49.6 2.6 9.7e-06 25.6 0.1 3.2 2 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ADV22335.1 - 1.2e-05 24.9 0.0 2.7e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 ADV22335.1 - 1.4e-05 25.0 24.2 1.4e-05 25.0 24.2 4.0 2 2 1 3 3 3 1 AAA ATPase domain AAA_23 PF13476.6 ADV22335.1 - 8.9e-05 23.1 33.5 8.9e-05 23.1 33.5 7.5 3 2 2 5 5 5 1 AAA domain ABC_tran PF00005.27 ADV22335.1 - 0.33 11.5 0.0 0.33 11.5 0.0 5.3 4 2 0 4 4 4 0 ABC transporter GCR1_C PF12550.8 ADV22335.1 - 1.8 8.9 7.1 2.7 8.4 3.0 3.6 2 1 0 2 2 2 0 Transcriptional activator of glycolytic enzymes ThrE PF06738.12 ADV22335.1 - 2.4 7.4 3.5 2.7 7.3 0.3 2.3 2 0 0 2 2 2 0 Putative threonine/serine exporter NPV_P10 PF05531.12 ADV22335.1 - 8 7.0 28.0 0.35 11.4 1.2 6.4 7 1 1 8 8 8 0 Nucleopolyhedrovirus P10 protein ABC1 PF03109.16 ADV22336.1 - 7.5e-33 113.2 0.0 1.3e-32 112.5 0.0 1.4 1 0 0 1 1 1 1 ABC1 family Pkinase PF00069.25 ADV22336.1 - 0.1 12.0 0.0 2 7.7 0.0 2.1 2 0 0 2 2 2 0 Protein kinase domain HEAT_EZ PF13513.6 ADV22337.1 - 7e-34 115.8 12.1 2.8e-14 53.2 0.0 10.3 10 1 1 11 11 10 6 HEAT-like repeat HEAT PF02985.22 ADV22337.1 - 1.2e-20 71.7 10.2 0.0029 17.7 0.0 11.3 12 0 0 12 12 12 4 HEAT repeat HEAT_2 PF13646.6 ADV22337.1 - 2.6e-15 56.5 0.2 0.022 15.1 0.0 6.8 5 2 2 7 7 7 4 HEAT repeats Cnd1 PF12717.7 ADV22337.1 - 1e-10 41.9 0.0 0.0052 16.8 0.0 4.4 3 1 1 4 4 4 3 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 ADV22337.1 - 5.3e-10 39.8 0.0 0.00052 20.6 0.0 4.8 3 1 1 4 4 4 3 Vacuolar 14 Fab1-binding region IBN_N PF03810.19 ADV22337.1 - 4.8e-06 26.4 0.0 0.00019 21.3 0.0 2.8 2 0 0 2 2 2 1 Importin-beta N-terminal domain CLASP_N PF12348.8 ADV22337.1 - 0.00012 21.7 0.0 2 7.9 0.0 4.4 4 1 0 5 5 5 2 CLASP N terminal DUF3437 PF11919.8 ADV22337.1 - 0.00052 19.9 0.3 1.9 8.4 0.0 4.5 4 1 1 5 5 5 1 Domain of unknown function (DUF3437) Adaptin_N PF01602.20 ADV22337.1 - 0.0071 15.0 0.0 0.52 8.8 0.0 3.0 2 1 1 3 3 3 1 Adaptin N terminal region VHS PF00790.19 ADV22337.1 - 0.0098 15.8 0.0 0.14 12.0 0.0 2.3 2 0 0 2 2 2 1 VHS domain Fanconi_A_N PF15865.5 ADV22337.1 - 0.083 12.3 0.0 0.33 10.3 0.0 2.0 2 0 0 2 2 2 0 Fanconi anaemia group A protein N terminus MMS19_C PF12460.8 ADV22337.1 - 1.6 7.8 3.7 1.8 7.6 0.1 2.9 4 0 0 4 4 4 0 RNAPII transcription regulator C-terminal DNA_pol_phi PF04931.13 ADV22337.1 - 7.4 4.5 10.5 8.4 4.4 9.5 1.6 2 0 0 2 2 2 0 DNA polymerase phi eIF-3c_N PF05470.12 ADV22338.1 - 1.1e-141 473.1 11.5 1.1e-141 473.1 11.5 3.3 2 1 1 3 3 3 1 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.27 ADV22338.1 - 4.3e-16 59.3 0.0 1.9e-15 57.3 0.0 2.2 1 0 0 1 1 1 1 PCI domain CDC45 PF02724.14 ADV22338.1 - 0.38 9.0 8.4 0.7 8.1 8.4 1.4 1 0 0 1 1 1 0 CDC45-like protein TFIIF_alpha PF05793.12 ADV22338.1 - 1.9 7.0 20.9 3.4 6.2 20.9 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) AA_permease_2 PF13520.6 ADV22339.1 - 1.1e-65 222.2 49.2 1.3e-65 221.9 49.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 ADV22339.1 - 3.5e-21 75.4 43.7 4.6e-21 75.0 43.7 1.0 1 0 0 1 1 1 1 Amino acid permease Gram_pos_anchor PF00746.21 ADV22339.1 - 0.18 11.8 0.3 1 9.3 0.0 2.5 2 0 0 2 2 2 0 LPXTG cell wall anchor motif PAP_central PF04928.17 ADV22339.1 - 0.38 9.7 1.2 3.1 6.7 0.3 2.3 3 0 0 3 3 3 0 Poly(A) polymerase central domain Gar1 PF04410.14 ADV22340.1 - 2.1e-28 99.0 1.8 3.6e-28 98.3 0.0 2.2 2 0 0 2 2 2 1 Gar1/Naf1 RNA binding region Membr_traf_MHD PF10540.9 ADV22340.1 - 0.96 9.6 2.9 0.72 10.0 0.4 1.9 2 0 0 2 2 2 0 Munc13 (mammalian uncoordinated) homology domain RRN3 PF05327.11 ADV22340.1 - 7.4 5.0 7.5 16 3.9 7.5 1.5 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Brix PF04427.18 ADV22342.1 - 1.5e-32 113.3 0.2 2.2e-32 112.7 0.2 1.3 1 0 0 1 1 1 1 Brix domain DUF1348 PF07080.11 ADV22343.1 - 4e-48 162.6 4.3 4.9e-48 162.3 4.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1348) SnoaL_2 PF12680.7 ADV22343.1 - 0.00016 22.3 0.1 0.00023 21.8 0.1 1.2 1 0 0 1 1 1 1 SnoaL-like domain PGM_PMM_I PF02878.16 ADV22344.1 - 2.7e-17 62.8 0.1 1.5e-07 31.2 0.0 2.7 2 1 1 3 3 3 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_IV PF00408.20 ADV22344.1 - 2.2e-11 43.8 0.1 5.9e-11 42.4 0.1 1.8 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_II PF02879.16 ADV22344.1 - 0.0013 19.3 0.1 0.0061 17.2 0.1 2.2 1 1 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 ADV22344.1 - 0.0017 18.5 0.2 0.0048 17.1 0.2 1.9 1 1 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III Memo PF01875.17 ADV22345.1 - 5.4e-72 242.2 0.0 6.2e-72 242.0 0.0 1.0 1 0 0 1 1 1 1 Memo-like protein PITH PF06201.13 ADV22346.1 - 6.4e-36 123.9 0.0 7.9e-36 123.6 0.0 1.1 1 0 0 1 1 1 1 PITH domain HSP90 PF00183.18 ADV22347.1 - 2.3e-136 455.7 0.6 3.5e-136 455.1 0.6 1.2 1 0 0 1 1 1 1 Hsp90 protein HATPase_c_3 PF13589.6 ADV22347.1 - 3.5e-08 33.4 0.2 1e-07 31.8 0.0 1.9 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 ADV22347.1 - 1.8e-07 31.7 0.1 4.8e-07 30.3 0.0 1.8 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Actin PF00022.19 ADV22349.1 - 3.6e-31 108.2 0.0 1e-29 103.4 0.0 2.6 2 1 0 2 2 2 1 Actin GATA PF00320.27 ADV22350.1 - 4.6e-14 51.7 6.5 8.2e-14 50.9 6.5 1.5 1 0 0 1 1 1 1 GATA zinc finger PAS_3 PF08447.12 ADV22350.1 - 2.2e-05 24.7 0.0 4.8e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 PAS fold zf-C4H2 PF10146.9 ADV22350.1 - 0.0035 17.7 0.1 0.0049 17.2 0.1 1.2 1 0 0 1 1 1 1 Zinc finger-containing protein PAS_9 PF13426.7 ADV22350.1 - 0.047 13.9 0.0 0.13 12.6 0.0 1.7 1 0 0 1 1 1 0 PAS domain HALZ PF02183.18 ADV22350.1 - 0.2 11.9 2.6 0.36 11.1 2.6 1.4 1 0 0 1 1 1 0 Homeobox associated leucine zipper HMA PF00403.26 ADV22351.1 - 3.9e-05 24.0 0.0 5.3e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 Heavy-metal-associated domain ABC_tran PF00005.27 ADV22353.1 - 6.2e-51 172.5 0.4 6.5e-29 101.2 0.2 3.2 3 0 0 3 3 3 2 ABC transporter ABC_membrane PF00664.23 ADV22353.1 - 1.4e-31 110.2 21.6 2.3e-16 60.3 8.8 2.4 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 ADV22353.1 - 6.2e-10 38.9 4.4 8.4e-05 22.1 2.1 3.7 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 ADV22353.1 - 2.6e-05 24.5 3.2 0.028 14.7 1.6 3.5 2 1 0 2 2 2 1 AAA domain AAA_29 PF13555.6 ADV22353.1 - 8.4e-05 22.2 1.0 0.41 10.4 0.1 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 ADV22353.1 - 0.0026 17.7 0.4 6.1 6.7 0.0 3.4 3 1 0 3 3 3 2 RsgA GTPase ATPase PF06745.13 ADV22353.1 - 0.037 13.4 0.7 0.73 9.1 0.0 2.3 2 0 0 2 2 2 0 KaiC AAA_23 PF13476.6 ADV22353.1 - 0.048 14.2 1.6 7.4 7.0 0.4 2.7 2 0 0 2 2 2 0 AAA domain T2SSE PF00437.20 ADV22353.1 - 0.053 12.6 0.1 11 5.0 0.0 2.5 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_16 PF13191.6 ADV22353.1 - 0.06 13.7 2.9 4.8 7.5 0.6 3.1 2 1 0 2 2 2 0 AAA ATPase domain AAA_10 PF12846.7 ADV22353.1 - 0.062 12.2 1.4 0.75 8.7 0.4 2.2 2 0 0 2 2 2 0 AAA-like domain MMR_HSR1 PF01926.23 ADV22353.1 - 0.067 13.3 0.8 3.1 7.9 0.1 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase NB-ARC PF00931.22 ADV22353.1 - 0.083 12.1 0.3 4.8 6.3 0.3 2.7 2 1 0 2 2 2 0 NB-ARC domain AAA_24 PF13479.6 ADV22353.1 - 0.1 12.3 0.3 0.55 9.9 0.1 2.1 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 ADV22353.1 - 0.4 10.2 4.7 0.84 9.2 0.0 2.7 3 0 0 3 3 3 0 AAA domain IstB_IS21 PF01695.17 ADV22353.1 - 0.83 9.4 4.5 18 5.0 0.1 3.5 4 0 0 4 4 4 0 IstB-like ATP binding protein AAA_21 PF13304.6 ADV22353.1 - 2.3 7.9 6.6 8.2 6.1 0.5 3.2 3 1 1 4 4 4 0 AAA domain, putative AbiEii toxin, Type IV TA system PNRC PF15365.6 ADV22355.1 - 0.0008 19.2 0.3 0.0008 19.2 0.3 3.3 3 0 0 3 3 3 1 Proline-rich nuclear receptor coactivator motif Sod_Fe_C PF02777.18 ADV22356.1 - 4.5e-05 23.5 0.0 0.0051 17.0 0.0 2.3 2 0 0 2 2 2 2 Iron/manganese superoxide dismutases, C-terminal domain RhoGEF PF00621.20 ADV22357.1 - 1.5e-31 110.0 0.0 2.1e-31 109.6 0.0 1.2 1 0 0 1 1 1 1 RhoGEF domain Trs65 PF12735.7 ADV22358.1 - 3.1e-49 168.1 0.0 4.3e-49 167.6 0.0 1.2 1 0 0 1 1 1 1 TRAPP trafficking subunit Trs65 Abhydrolase_3 PF07859.13 ADV22359.1 - 1.8e-33 116.2 0.0 1.5e-26 93.6 0.0 2.4 2 0 0 2 2 2 2 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 ADV22359.1 - 1.4e-08 34.0 0.0 7.2e-08 31.7 0.0 2.0 2 1 0 2 2 2 1 Steryl acetyl hydrolase Cgr1 PF03879.14 ADV22360.1 - 2.7e-28 98.5 29.6 3.1e-28 98.3 29.6 1.0 1 0 0 1 1 1 1 Cgr1 family DUF737 PF05300.11 ADV22360.1 - 0.0021 18.4 18.1 0.0024 18.3 18.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF737) RRT14 PF17075.5 ADV22360.1 - 0.0079 16.3 13.8 0.0094 16.1 13.8 1.1 1 0 0 1 1 1 1 Regular of rDNA transcription protein 14 VIR_N PF15912.5 ADV22360.1 - 0.63 9.6 6.7 0.67 9.5 6.7 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal STAT_bind PF02864.15 ADV22360.1 - 0.81 10.2 6.6 1.2 9.7 6.6 1.4 1 0 0 1 1 1 0 STAT protein, DNA binding domain AAA_11 PF13086.6 ADV22360.1 - 0.96 9.2 11.8 1 9.1 11.8 1.1 1 0 0 1 1 1 0 AAA domain PA26 PF04636.13 ADV22360.1 - 1.5 7.7 6.7 1.5 7.6 6.7 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Silic_transp PF03842.13 ADV22360.1 - 6.2 5.0 5.0 6.5 4.9 5.0 1.0 1 0 0 1 1 1 0 Silicon transporter RR_TM4-6 PF06459.12 ADV22360.1 - 6.6 6.5 14.8 7.2 6.4 14.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Tli4_N PF18443.1 ADV22360.1 - 8.8 6.7 12.7 75 3.7 12.7 2.1 1 1 0 1 1 1 0 Tle cognate immunity protein 4 N-terminal domain CBM_21 PF03370.13 ADV22361.1 - 3.9e-27 94.7 0.0 6.6e-27 93.9 0.0 1.4 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.5 ADV22361.1 - 1.8e-07 31.6 0.7 4.3e-07 30.4 0.7 1.6 1 0 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) PLDc PF00614.22 ADV22362.1 - 2e-12 46.7 2.3 5.9e-06 26.2 0.4 2.6 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_2 PF13091.6 ADV22362.1 - 1.3e-11 44.6 1.0 9e-08 32.1 0.1 3.3 3 0 0 3 3 3 3 PLD-like domain Sgf11 PF08209.11 ADV22363.1 - 5.6e-14 51.4 1.0 1.2e-13 50.4 0.3 1.9 2 0 0 2 2 2 1 Sgf11 (transcriptional regulation protein) Elf1 PF05129.13 ADV22363.1 - 0.099 12.7 1.5 0.75 9.9 0.2 2.4 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like TB2_DP1_HVA22 PF03134.19 ADV22364.1 - 6.9e-23 80.4 5.2 1.2e-22 79.7 5.2 1.4 1 0 0 1 1 1 1 TB2/DP1, HVA22 family CDT1_C PF16679.5 ADV22366.1 - 5.1e-16 58.9 0.0 1.1e-15 57.8 0.0 1.6 1 0 0 1 1 1 1 DNA replication factor Cdt1 C-terminal domain PmoA PF14100.6 ADV22366.1 - 0.014 14.9 0.1 0.025 14.1 0.1 1.4 1 0 0 1 1 1 0 Methane oxygenase PmoA Peptidase_S76 PF13611.6 ADV22367.1 - 0.11 12.8 0.0 0.14 12.5 0.0 1.1 1 0 0 1 1 1 0 Serine peptidase of plant viral polyprotein, P1 Annexin PF00191.20 ADV22368.1 - 3.5e-55 183.9 0.3 8.3e-15 54.6 0.0 4.1 4 0 0 4 4 4 4 Annexin Acetyltransf_11 PF13720.6 ADV22368.1 - 0.047 14.2 1.3 2 8.9 0.1 2.7 3 0 0 3 3 3 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 NDC10_II PF16787.5 ADV22369.1 - 1.2e-73 248.0 0.0 1.6e-73 247.6 0.0 1.2 1 0 0 1 1 1 1 Centromere DNA-binding protein complex CBF3 subunit, domain 2 GCR1_C PF12550.8 ADV22369.1 - 8.6e-16 58.0 0.4 1.8e-15 57.0 0.4 1.6 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes tRNA-synt_2 PF00152.20 ADV22370.1 - 1.8e-81 273.7 0.0 3.3e-81 272.8 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 ADV22370.1 - 2.1e-10 40.5 0.2 4.8e-10 39.3 0.2 1.7 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain TPR_14 PF13428.6 ADV22373.1 - 1.6e-11 44.0 10.4 4.3 8.4 0.0 10.3 9 1 1 10 10 10 2 Tetratricopeptide repeat TPR_19 PF14559.6 ADV22373.1 - 8.6e-07 29.4 3.2 1.4 9.5 0.1 5.4 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 ADV22373.1 - 1.2e-06 28.2 18.3 0.042 14.0 0.1 7.5 9 0 0 9 9 8 3 Tetratricopeptide repeat TPR_8 PF13181.6 ADV22373.1 - 4.4e-05 23.4 7.5 17 6.0 0.0 7.7 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_12 PF13424.6 ADV22373.1 - 0.00019 21.7 12.8 0.59 10.5 0.1 6.2 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_1 PF00515.28 ADV22373.1 - 0.00028 20.6 3.6 13 5.8 0.1 5.5 6 0 0 6 6 6 1 Tetratricopeptide repeat Suf PF05843.14 ADV22373.1 - 0.0004 20.5 16.0 0.018 15.0 2.4 5.3 4 1 0 5 5 5 2 Suppressor of forked protein (Suf) Mad3_BUB1_I PF08311.12 ADV22373.1 - 0.00041 20.3 17.6 0.072 13.1 3.2 6.9 7 1 0 7 7 7 1 Mad3/BUB1 homology region 1 MIT PF04212.18 ADV22373.1 - 0.0026 17.8 0.3 0.61 10.2 0.1 3.8 2 1 1 3 3 3 1 MIT (microtubule interacting and transport) domain TPR_17 PF13431.6 ADV22373.1 - 0.0059 16.9 6.7 34 5.1 0.1 7.0 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_6 PF13174.6 ADV22373.1 - 0.25 12.1 10.9 44 5.0 0.0 7.3 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_16 PF13432.6 ADV22373.1 - 4.2 8.1 17.7 3.5 8.3 0.1 5.9 6 2 0 6 6 6 0 Tetratricopeptide repeat Isochorismatase PF00857.20 ADV22374.1 - 1.2e-16 61.4 0.0 2.8e-16 60.2 0.0 1.6 1 1 0 1 1 1 1 Isochorismatase family GCFC PF07842.12 ADV22375.1 - 0.0098 15.5 0.0 0.92 9.1 0.0 2.7 1 1 0 1 1 1 1 GC-rich sequence DNA-binding factor-like protein CENP-K PF11802.8 ADV22375.1 - 0.066 12.8 1.1 0.12 12.0 1.1 1.3 1 0 0 1 1 1 0 Centromere-associated protein K V_ATPase_I PF01496.19 ADV22375.1 - 0.39 8.6 0.5 0.58 8.0 0.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TatD_DNase PF01026.21 ADV22376.1 - 4.6e-47 160.5 0.0 6.9e-47 160.0 0.0 1.2 1 0 0 1 1 1 1 TatD related DNase Evr1_Alr PF04777.13 ADV22377.1 - 3.4e-27 94.8 0.0 5.9e-27 94.1 0.0 1.4 1 0 0 1 1 1 1 Erv1 / Alr family APOBEC4 PF18775.1 ADV22377.1 - 0.14 12.4 0.3 0.23 11.6 0.3 1.4 1 0 0 1 1 1 0 APOBEC4 S1 PF00575.23 ADV22378.1 - 6.2e-57 189.9 27.1 2.6e-10 40.5 1.9 9.7 10 0 0 10 10 10 8 S1 RNA binding domain Suf PF05843.14 ADV22378.1 - 1.1e-08 35.5 5.3 9.3e-06 25.8 0.0 3.6 3 1 1 4 4 4 2 Suppressor of forked protein (Suf) TPR_19 PF14559.6 ADV22378.1 - 2e-06 28.2 0.0 0.11 13.1 0.0 4.0 2 1 1 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 ADV22378.1 - 3.7e-05 24.2 0.4 15 6.8 0.1 5.2 3 1 3 6 6 6 0 Tetratricopeptide repeat NRDE-2 PF08424.10 ADV22378.1 - 0.0007 18.8 2.9 0.036 13.2 3.2 3.1 1 1 1 2 2 2 1 NRDE-2, necessary for RNA interference TPR_6 PF13174.6 ADV22378.1 - 0.0014 19.1 0.1 0.23 12.2 0.0 3.5 3 0 0 3 3 2 1 Tetratricopeptide repeat S1_2 PF13509.6 ADV22378.1 - 0.0037 17.3 6.6 10 6.3 0.0 6.7 8 1 0 8 8 7 1 S1 domain RPN7 PF10602.9 ADV22378.1 - 0.02 14.6 0.5 0.21 11.3 0.3 2.4 1 1 1 2 2 2 0 26S proteasome subunit RPN7 TPR_17 PF13431.6 ADV22378.1 - 0.029 14.7 0.1 7.6 7.2 0.0 3.1 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 ADV22378.1 - 0.063 13.9 0.1 27 5.5 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat SesA PF17107.5 ADV22378.1 - 0.12 12.6 1.3 0.29 11.3 0.2 2.3 2 0 0 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases RNase_II_C_S1 PF18614.1 ADV22378.1 - 0.14 12.1 5.3 8.4 6.4 0.0 4.8 4 1 1 5 5 5 0 RNase II-type exonuclease C-terminal S1 domain CDC45 PF02724.14 ADV22378.1 - 4.6 5.4 18.5 3.7 5.7 10.2 2.3 2 0 0 2 2 2 0 CDC45-like protein RhoGEF PF00621.20 ADV22379.1 - 4.1e-34 118.4 0.2 5.4e-34 118.0 0.2 1.2 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 ADV22379.1 - 0.017 15.6 0.0 0.032 14.7 0.0 1.5 1 0 0 1 1 1 0 PH domain DUF4131 PF13567.6 ADV22381.1 - 0.021 14.5 0.0 0.028 14.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) AMP-binding PF00501.28 ADV22382.1 - 1.7e-80 270.7 0.0 2.3e-80 270.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ADV22382.1 - 1.4e-15 58.0 1.2 3.6e-15 56.7 1.2 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Metallophos PF00149.28 ADV22383.1 - 1.6e-05 25.5 0.7 3.9e-05 24.2 0.7 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase PTPlike_phytase PF14566.6 ADV22384.1 - 1.7e-134 444.1 2.3 7.6e-47 159.3 0.3 4.1 4 0 0 4 4 4 3 Inositol hexakisphosphate DSPc PF00782.20 ADV22384.1 - 0.0012 18.7 0.0 8.2 6.2 0.0 4.2 4 0 0 4 4 4 2 Dual specificity phosphatase, catalytic domain ORC5_C PF14630.6 ADV22384.1 - 0.075 12.5 0.3 0.31 10.5 0.1 2.0 2 0 0 2 2 2 0 Origin recognition complex (ORC) subunit 5 C-terminus DBI_PRT PF02277.17 ADV22384.1 - 0.11 11.7 0.0 0.21 10.8 0.0 1.4 1 0 0 1 1 1 0 Phosphoribosyltransferase HTH_1 PF00126.27 ADV22384.1 - 0.11 12.5 0.0 33 4.5 0.0 3.6 2 1 1 3 3 3 0 Bacterial regulatory helix-turn-helix protein, lysR family RhoGAP PF00620.27 ADV22385.1 - 3.2e-10 40.0 0.0 2.5e-07 30.6 0.0 2.5 2 0 0 2 2 2 2 RhoGAP domain DEP PF00610.21 ADV22385.1 - 0.0041 17.2 0.0 0.0087 16.1 0.0 1.5 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Coprogen_oxidas PF01218.18 ADV22386.1 - 7.2e-132 438.6 0.0 8.2e-132 438.4 0.0 1.0 1 0 0 1 1 1 1 Coproporphyrinogen III oxidase DUF3500 PF12006.8 ADV22387.1 - 3.9e-92 308.9 0.0 4.6e-92 308.7 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3500) Adaptin_N PF01602.20 ADV22388.1 - 9.3e-66 222.5 0.0 1.3e-65 221.9 0.0 1.2 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 ADV22388.1 - 2.4e-08 34.2 0.0 0.00018 21.6 0.0 3.3 3 1 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 ADV22388.1 - 8.7e-06 26.0 2.0 0.32 11.4 0.1 3.6 3 0 0 3 3 3 2 HEAT repeats HEAT PF02985.22 ADV22388.1 - 5.9e-05 23.0 3.3 0.72 10.3 0.1 4.6 4 0 0 4 4 4 2 HEAT repeat Metallophos PF00149.28 ADV22389.1 - 3.6e-12 47.2 0.3 7.1e-12 46.3 0.3 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ADV22389.1 - 3e-07 30.8 0.0 6.5e-07 29.7 0.0 1.6 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain PAC1 PF16094.5 ADV22389.1 - 0.082 12.1 0.4 0.13 11.4 0.4 1.2 1 0 0 1 1 1 0 Proteasome assembly chaperone 4 FBPase_2 PF06874.11 ADV22389.1 - 0.3 9.3 0.2 1.8 6.8 0.1 1.9 1 1 1 2 2 2 0 Firmicute fructose-1,6-bisphosphatase EMP70 PF02990.16 ADV22390.1 - 2.5e-194 646.8 3.9 2.5e-194 646.8 3.9 1.9 2 0 0 2 2 2 1 Endomembrane protein 70 Pyr_redox_3 PF13738.6 ADV22391.1 - 1.8e-19 70.2 0.0 7.5e-18 64.8 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 ADV22391.1 - 5.8e-19 67.9 0.0 1.5e-13 50.0 0.0 2.6 2 1 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 ADV22391.1 - 8.8e-15 54.7 0.0 7.9e-12 45.0 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ADV22391.1 - 3.5e-08 33.9 0.3 0.029 14.9 0.1 4.5 5 0 0 5 5 4 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 ADV22391.1 - 9.1e-07 28.3 0.0 0.00023 20.4 0.0 2.9 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 ADV22391.1 - 9.1e-07 29.0 0.0 0.0019 18.4 0.0 2.5 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 ADV22391.1 - 5.8e-06 25.8 0.2 8.8e-05 21.9 0.3 2.2 2 0 0 2 2 2 1 FAD binding domain Thi4 PF01946.17 ADV22391.1 - 0.00016 21.0 0.0 0.64 9.2 0.0 2.4 2 0 0 2 2 2 2 Thi4 family DAO PF01266.24 ADV22391.1 - 0.00024 20.8 0.0 0.046 13.3 0.0 3.1 3 1 1 4 4 4 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 ADV22391.1 - 0.00074 19.0 1.4 0.7 9.2 0.9 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase HI0933_like PF03486.14 ADV22391.1 - 0.0018 17.0 0.0 0.11 11.2 0.1 2.4 2 0 0 2 2 2 1 HI0933-like protein Lycopene_cycl PF05834.12 ADV22391.1 - 0.0022 17.1 0.0 0.013 14.5 0.0 2.2 3 0 0 3 3 3 1 Lycopene cyclase protein GIDA PF01134.22 ADV22391.1 - 0.0042 16.2 0.2 1.7 7.6 0.0 2.6 3 0 0 3 3 3 2 Glucose inhibited division protein A NAD_binding_9 PF13454.6 ADV22391.1 - 0.0091 16.0 0.3 2.1 8.3 0.1 3.0 2 1 1 3 3 3 1 FAD-NAD(P)-binding 2-Hacid_dh_C PF02826.19 ADV22391.1 - 0.01 15.2 0.0 0.69 9.2 0.0 2.3 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FAD_binding_2 PF00890.24 ADV22391.1 - 0.012 14.7 1.0 0.18 10.9 0.9 2.2 2 0 0 2 2 2 0 FAD binding domain Eno-Rase_NADH_b PF12242.8 ADV22391.1 - 0.13 12.0 0.0 18 5.2 0.0 2.4 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase IlvN PF07991.12 ADV22391.1 - 0.18 11.4 0.2 17 4.9 0.0 2.8 3 0 0 3 3 3 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain Isochorismatase PF00857.20 ADV22392.1 - 1.2e-26 93.9 0.1 1.5e-26 93.7 0.1 1.1 1 0 0 1 1 1 1 Isochorismatase family DUF763 PF05559.11 ADV22392.1 - 0.12 11.5 0.0 0.15 11.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF763) CDC45 PF02724.14 ADV22393.1 - 5.5e-211 702.2 0.0 6.2e-211 702.1 0.0 1.0 1 0 0 1 1 1 1 CDC45-like protein SDA1 PF05285.12 ADV22393.1 - 3.3 7.1 16.0 0.042 13.3 8.6 1.5 2 0 0 2 2 2 0 SDA1 DNA_pol_phi PF04931.13 ADV22393.1 - 6.1 4.8 13.4 9.6 4.2 13.4 1.2 1 0 0 1 1 1 0 DNA polymerase phi Paf1 PF03985.13 ADV22393.1 - 6.4 5.7 12.1 13 4.7 12.1 1.4 1 0 0 1 1 1 0 Paf1 Nop14 PF04147.12 ADV22393.1 - 8.4 4.5 13.9 13 3.8 13.9 1.2 1 0 0 1 1 1 0 Nop14-like family Complex1_LYR PF05347.15 ADV22394.1 - 1.8e-09 37.5 2.5 2.8e-09 36.9 2.5 1.3 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 ADV22394.1 - 0.12 13.2 0.5 0.19 12.5 0.5 1.3 1 0 0 1 1 1 0 Complex1_LYR-like WD40 PF00400.32 ADV22396.1 - 1.5e-06 28.8 0.5 0.06 14.2 0.0 4.0 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV22396.1 - 0.0077 16.5 0.1 2.9 8.3 0.0 4.2 5 1 1 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Proteasom_Rpn13 PF04683.13 ADV22397.1 - 2e-25 89.1 0.2 3e-25 88.6 0.2 1.3 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor RPN13_C PF16550.5 ADV22397.1 - 9e-21 74.2 0.0 1.6e-20 73.4 0.0 1.4 1 0 0 1 1 1 1 UCH-binding domain Pyr_redox_2 PF07992.14 ADV22398.1 - 4.6e-66 223.0 0.6 6.9e-66 222.5 0.6 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 ADV22398.1 - 2.4e-32 111.5 0.0 8.9e-32 109.6 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 ADV22398.1 - 1.7e-21 76.5 1.5 1.5e-18 67.1 0.0 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ADV22398.1 - 8.8e-17 61.3 2.6 7.7e-16 58.2 0.1 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 ADV22398.1 - 8.8e-09 34.9 0.0 4e-08 32.8 0.1 1.7 1 1 1 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.14 ADV22398.1 - 1.4e-08 33.8 0.7 0.0019 17.0 0.0 3.1 3 0 0 3 3 3 2 HI0933-like protein FAD_oxidored PF12831.7 ADV22398.1 - 1.3e-06 28.1 0.1 2e-06 27.4 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 ADV22398.1 - 0.00015 21.0 6.1 0.12 11.4 1.8 3.1 3 0 0 3 3 3 2 FAD binding domain NAD_binding_8 PF13450.6 ADV22398.1 - 0.00049 20.3 1.7 0.0013 18.9 1.7 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain AlaDh_PNT_C PF01262.21 ADV22398.1 - 0.0039 16.5 2.3 0.17 11.1 0.2 2.5 2 1 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 ADV22398.1 - 0.018 14.2 1.9 0.043 12.9 0.3 2.3 3 0 0 3 3 3 0 Glucose inhibited division protein A 2-Hacid_dh_C PF02826.19 ADV22398.1 - 0.022 14.1 0.5 0.58 9.5 0.0 2.7 3 0 0 3 3 3 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 ADV22398.1 - 0.04 13.8 1.0 0.23 11.3 0.0 2.2 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF4930 PF16284.5 ADV22398.1 - 0.059 13.4 0.1 12 5.8 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4930) Lycopene_cycl PF05834.12 ADV22398.1 - 0.16 11.0 0.6 0.41 9.6 0.4 1.7 2 0 0 2 2 2 0 Lycopene cyclase protein NAD_binding_7 PF13241.6 ADV22398.1 - 0.19 12.2 0.4 24 5.5 0.1 2.5 2 1 0 2 2 2 0 Putative NAD(P)-binding Thi4 PF01946.17 ADV22398.1 - 0.67 9.1 4.3 0.27 10.4 0.5 2.3 3 0 0 3 3 3 0 Thi4 family FAD_binding_3 PF01494.19 ADV22398.1 - 2.4 7.3 5.8 36 3.5 0.5 3.5 3 1 1 4 4 4 0 FAD binding domain Nkap_C PF06047.11 ADV22399.1 - 3.1e-41 139.6 3.7 3.1e-41 139.6 3.7 2.7 2 1 1 3 3 3 1 NF-kappa-B-activating protein C-terminal domain VKG_Carbox PF05090.14 ADV22399.1 - 0.17 10.7 0.1 0.27 10.0 0.1 1.2 1 0 0 1 1 1 0 Vitamin K-dependent gamma-carboxylase UCH PF00443.29 ADV22400.1 - 1.3e-45 155.9 0.0 6.7e-36 124.1 0.0 2.1 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ADV22400.1 - 9.7e-19 68.1 0.9 3.1e-15 56.6 0.1 2.2 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 ADV22400.1 - 0.0019 17.8 3.2 0.2 11.1 0.8 3.2 3 1 0 3 3 3 2 Ubiquitin-specific peptidase-like, SUMO isopeptidase Pkinase PF00069.25 ADV22401.1 - 9e-53 179.3 0.0 2.8e-52 177.7 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV22401.1 - 5.9e-20 71.6 0.4 5e-16 58.8 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase FTA2 PF13095.6 ADV22401.1 - 2.3e-05 24.1 0.1 0.3 10.7 0.0 3.2 2 1 0 3 3 3 2 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 ADV22401.1 - 0.15 11.4 0.1 0.37 10.1 0.0 1.6 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family AAA_33 PF13671.6 ADV22402.1 - 4.8e-12 46.2 0.0 8.2e-12 45.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ADV22402.1 - 8.6e-05 23.1 0.0 0.00031 21.3 0.0 1.9 1 1 0 1 1 1 1 AAA domain KTI12 PF08433.10 ADV22402.1 - 0.0011 18.4 0.0 0.0017 17.9 0.0 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA PF00004.29 ADV22402.1 - 0.0036 17.7 0.0 0.0073 16.7 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.6 ADV22402.1 - 0.004 17.6 0.1 0.019 15.4 0.1 2.1 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 ADV22402.1 - 0.013 15.7 0.0 0.025 14.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 ADV22402.1 - 0.013 15.5 0.0 0.14 12.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) ABC_tran PF00005.27 ADV22402.1 - 0.013 16.0 0.0 0.04 14.4 0.0 1.7 2 0 0 2 2 2 0 ABC transporter 6PF2K PF01591.18 ADV22402.1 - 0.031 13.6 0.0 0.048 13.0 0.0 1.2 1 0 0 1 1 1 0 6-phosphofructo-2-kinase TsaE PF02367.17 ADV22402.1 - 0.033 14.2 0.0 0.049 13.6 0.0 1.2 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Zeta_toxin PF06414.12 ADV22402.1 - 0.035 13.4 0.0 0.12 11.7 0.0 1.8 2 0 0 2 2 2 0 Zeta toxin AAA_30 PF13604.6 ADV22402.1 - 0.053 13.2 0.0 0.094 12.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 ADV22402.1 - 0.062 13.2 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_25 PF13481.6 ADV22402.1 - 0.1 12.2 0.1 0.17 11.4 0.1 1.4 1 1 0 1 1 1 0 AAA domain NB-ARC PF00931.22 ADV22402.1 - 0.1 11.8 0.0 0.16 11.1 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain MMR_HSR1 PF01926.23 ADV22402.1 - 0.11 12.5 0.0 0.43 10.7 0.0 1.9 2 1 0 2 2 2 0 50S ribosome-binding GTPase AAA_16 PF13191.6 ADV22402.1 - 0.12 12.7 0.0 0.22 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain cobW PF02492.19 ADV22402.1 - 0.26 10.9 0.0 0.4 10.2 0.0 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Velvet PF11754.8 ADV22403.1 - 2e-16 60.7 0.1 2e-16 60.7 0.1 2.7 2 1 1 3 3 3 1 Velvet factor DNA_primase_S PF01896.19 ADV22404.1 - 1.8e-56 190.9 0.1 2.6e-56 190.5 0.1 1.2 1 0 0 1 1 1 1 DNA primase small subunit RPT PF13446.6 ADV22404.1 - 0.041 13.8 0.0 0.11 12.4 0.0 1.7 1 0 0 1 1 1 0 A repeated domain in UCH-protein Stealth_CR4 PF17103.5 ADV22404.1 - 2.9 7.9 6.9 24 4.9 0.3 3.7 4 0 0 4 4 4 0 Stealth protein CR4, conserved region 4 DUF2034 PF10356.9 ADV22405.1 - 1.4e-23 83.3 0.1 4.6e-22 78.3 0.1 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF2034) Mrr_cat PF04471.12 ADV22405.1 - 1.2e-11 44.7 0.0 3.3e-11 43.2 0.0 1.7 1 1 0 1 1 1 1 Restriction endonuclease Brix PF04427.18 ADV22406.1 - 4.3e-37 128.1 0.0 5.7e-37 127.7 0.0 1.2 1 0 0 1 1 1 1 Brix domain DUF3824 PF12868.7 ADV22406.1 - 0.6 10.8 3.6 1.1 9.9 3.6 1.4 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) DUF2922 PF11148.8 ADV22407.1 - 0.063 13.0 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2922) CDC45 PF02724.14 ADV22407.1 - 0.34 9.1 15.8 0.35 9.1 15.8 1.1 1 0 0 1 1 1 0 CDC45-like protein Vfa1 PF08432.10 ADV22407.1 - 2.4 8.4 13.3 3.7 7.9 13.3 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DNA_pol_phi PF04931.13 ADV22407.1 - 2.9 5.9 18.4 4.9 5.1 18.4 1.3 1 0 0 1 1 1 0 DNA polymerase phi Aminotran_1_2 PF00155.21 ADV22408.1 - 2.4e-35 122.4 0.0 3.5e-35 121.9 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II PV-1 PF06637.11 ADV22408.1 - 0.00056 18.9 14.2 0.00077 18.4 14.2 1.2 1 0 0 1 1 1 1 PV-1 protein (PLVAP) AAA_11 PF13086.6 ADV22408.1 - 0.0055 16.5 8.2 0.0074 16.1 8.2 1.2 1 0 0 1 1 1 1 AAA domain Hydin_ADK PF17213.3 ADV22408.1 - 0.3 11.3 12.6 0.56 10.5 12.6 1.3 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain CAF1 PF04857.20 ADV22408.1 - 0.53 9.4 4.8 0.77 8.9 4.8 1.2 1 0 0 1 1 1 0 CAF1 family ribonuclease Aldedh PF00171.22 ADV22409.1 - 1.2e-123 413.1 0.1 1.4e-123 412.9 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 ADV22409.1 - 0.11 11.5 0.2 0.2 10.6 0.2 1.5 1 1 0 1 1 1 0 Acyl-CoA reductase (LuxC) GCP_N_terminal PF17681.1 ADV22411.1 - 5.8e-26 91.8 0.0 1.3e-25 90.7 0.0 1.6 1 1 0 1 1 1 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 ADV22411.1 - 1.2e-20 74.2 0.0 3.1e-20 72.9 0.0 1.6 1 1 0 1 1 1 1 Gamma tubulin complex component C-terminal Steroid_dh PF02544.16 ADV22412.1 - 8.3e-16 58.3 0.3 1.2e-15 57.8 0.3 1.3 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase ubiquitin PF00240.23 ADV22412.1 - 0.0045 16.7 0.0 0.011 15.5 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.6 ADV22412.1 - 0.028 14.9 0.0 0.071 13.6 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin-like domain Amidase PF01425.21 ADV22413.1 - 8.6e-100 334.8 0.0 1.1e-99 334.5 0.0 1.1 1 0 0 1 1 1 1 Amidase XkdW PF09636.10 ADV22413.1 - 0.087 12.9 0.2 0.24 11.5 0.2 1.7 1 0 0 1 1 1 0 XkdW protein MFS_1 PF07690.16 ADV22414.1 - 1.6e-31 109.6 19.0 1.6e-31 109.6 19.0 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily WW PF00397.26 ADV22415.1 - 6.8e-08 32.5 1.6 1.6e-07 31.3 1.6 1.7 1 0 0 1 1 1 1 WW domain DUF2076 PF09849.9 ADV22415.1 - 7.2e-05 23.0 27.0 7.2e-05 23.0 27.0 2.5 1 1 1 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2076) TFIIA PF03153.13 ADV22415.1 - 1.7 8.6 13.1 1.9 8.4 13.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Ribosomal_S25 PF03297.15 ADV22416.1 - 8.2e-43 144.7 6.1 9e-43 144.6 6.1 1.0 1 0 0 1 1 1 1 S25 ribosomal protein HTH_24 PF13412.6 ADV22416.1 - 0.0023 17.5 0.1 0.0033 17.0 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding MarR PF01047.22 ADV22416.1 - 0.019 14.8 0.1 0.028 14.3 0.1 1.2 1 0 0 1 1 1 0 MarR family RPA_C PF08784.11 ADV22416.1 - 0.025 15.2 0.0 0.031 14.9 0.0 1.1 1 0 0 1 1 1 0 Replication protein A C terminal MarR_2 PF12802.7 ADV22416.1 - 0.084 12.8 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 MarR family Pkinase PF00069.25 ADV22417.1 - 8e-62 209.0 0.0 9.8e-62 208.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV22417.1 - 4.8e-37 127.7 0.0 7.2e-37 127.1 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ADV22417.1 - 5.4e-06 25.9 0.0 2e-05 24.1 0.0 1.8 2 1 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 ADV22417.1 - 4.6e-05 22.4 0.0 8.3e-05 21.5 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 ADV22417.1 - 0.011 15.7 0.0 0.018 15.0 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.9 ADV22417.1 - 0.14 11.6 0.0 0.26 10.8 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Seadorna_VP7 PF07387.11 ADV22417.1 - 0.2 10.7 0.0 0.37 9.8 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Kdo PF06293.14 ADV22417.1 - 0.22 10.8 0.0 0.45 9.8 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family UAA PF08449.11 ADV22418.1 - 4.6e-88 295.3 8.0 8e-88 294.5 8.0 1.4 1 1 0 1 1 1 1 UAA transporter family TPT PF03151.16 ADV22418.1 - 0.00057 19.3 0.8 0.00057 19.3 0.8 2.1 2 0 0 2 2 2 1 Triose-phosphate Transporter family CRT-like PF08627.10 ADV22418.1 - 0.0046 15.9 0.6 0.0084 15.1 0.6 1.4 1 0 0 1 1 1 1 CRT-like, chloroquine-resistance transporter-like EamA PF00892.20 ADV22418.1 - 0.5 10.5 28.8 3.4 7.9 13.6 3.6 2 2 0 2 2 2 0 EamA-like transporter family Nuc_sug_transp PF04142.15 ADV22418.1 - 0.55 9.4 5.4 0.13 11.4 0.1 2.3 2 1 0 2 2 2 0 Nucleotide-sugar transporter DUF3419 PF11899.8 ADV22419.1 - 3.5e-131 437.9 0.0 1.2e-79 268.3 0.0 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF3419) Methyltransf_11 PF08241.12 ADV22419.1 - 2.9e-05 24.6 0.0 0.016 15.8 0.0 2.8 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_25 PF13649.6 ADV22419.1 - 4.5e-05 24.1 0.0 0.00045 20.9 0.0 2.5 3 0 0 3 3 3 1 Methyltransferase domain Ubie_methyltran PF01209.18 ADV22419.1 - 0.00097 18.5 0.0 0.032 13.6 0.0 2.2 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 ADV22419.1 - 0.022 14.6 0.0 0.067 13.0 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_4 PF02390.17 ADV22419.1 - 0.023 14.2 0.0 0.13 11.8 0.0 2.0 2 0 0 2 2 2 0 Putative methyltransferase Methyltransf_31 PF13847.6 ADV22419.1 - 0.1 12.4 0.0 1.4 8.7 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain Synaptobrevin PF00957.21 ADV22420.1 - 0.045 13.6 1.1 0.087 12.6 1.1 1.4 1 0 0 1 1 1 0 Synaptobrevin SWI-SNF_Ssr4 PF08549.10 ADV22420.1 - 0.12 11.0 14.2 0.56 8.8 14.1 2.1 1 1 0 1 1 1 0 Fungal domain of unknown function (DUF1750) SICA_alpha PF12887.7 ADV22420.1 - 0.13 12.1 3.7 0.21 11.5 3.7 1.3 1 0 0 1 1 1 0 SICA extracellular alpha domain SPT_ssu-like PF11779.8 ADV22421.1 - 9e-09 34.8 3.3 1.2e-08 34.5 3.3 1.2 1 0 0 1 1 1 1 Small subunit of serine palmitoyltransferase-like DUF1648 PF07853.11 ADV22421.1 - 0.015 14.9 0.8 0.03 14.0 0.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1648) OSTMP1 PF09777.9 ADV22421.1 - 0.37 10.2 0.7 0.45 9.9 0.7 1.1 1 0 0 1 1 1 0 Osteopetrosis-associated transmembrane protein 1 precursor UPRTase PF14681.6 ADV22423.1 - 1.4e-64 217.3 0.0 1.6e-64 217.2 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 ADV22423.1 - 0.0002 20.9 0.0 0.00026 20.5 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Arrestin_C PF02752.22 ADV22425.1 - 2.3e-15 57.3 0.1 6.6e-14 52.5 0.0 3.1 3 1 0 3 3 3 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 ADV22425.1 - 2.4e-12 47.2 0.0 1.1e-06 28.8 0.0 2.8 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain LDB19 PF13002.7 ADV22425.1 - 0.02 14.6 0.0 0.044 13.5 0.0 1.5 1 0 0 1 1 1 0 Arrestin_N terminal like MFS_1 PF07690.16 ADV22426.1 - 2.9e-46 158.0 41.2 4.2e-46 157.5 41.2 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 ADV22426.1 - 1.9e-13 49.8 13.8 2.6e-13 49.3 13.8 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 ADV22426.1 - 1.7e-12 47.0 8.2 1.7e-12 47.0 8.2 2.3 3 0 0 3 3 3 1 Sugar (and other) transporter Tetraspanin PF00335.20 ADV22426.1 - 3.2 7.4 7.1 1.3 8.7 3.0 2.4 2 0 0 2 2 2 0 Tetraspanin family Ribosomal_L21e PF01157.18 ADV22430.1 - 1.3e-44 150.1 5.3 1.7e-44 149.8 4.0 1.7 2 0 0 2 2 2 1 Ribosomal protein L21e AAA_18 PF13238.6 ADV22430.1 - 0.0027 18.3 0.0 0.0036 17.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain LRS4 PF10422.9 ADV22430.1 - 0.026 14.1 0.0 0.031 13.9 0.0 1.1 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 DUF1640 PF07798.11 ADV22431.1 - 2.3e-50 171.1 8.1 2.3e-50 171.1 8.1 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1640) RNase_J_C PF17770.1 ADV22431.1 - 8.1 7.6 7.6 28 5.9 0.8 3.3 3 1 1 4 4 4 0 Ribonuclease J C-terminal domain ATP-synt_ab PF00006.25 ADV22432.1 - 4.2e-105 350.1 0.0 6e-105 349.6 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_Xtn PF16886.5 ADV22432.1 - 7.3e-45 151.7 0.0 1.5e-44 150.7 0.0 1.6 1 0 0 1 1 1 1 ATPsynthase alpha/beta subunit N-term extension ATP-synt_ab_N PF02874.23 ADV22432.1 - 1.2e-14 54.6 2.9 3.7e-14 53.0 2.9 1.9 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain Amidohydro_1 PF01979.20 ADV22432.1 - 0.16 11.3 0.0 1.7 7.8 0.0 2.1 2 0 0 2 2 2 0 Amidohydrolase family Peptidase_M24 PF00557.24 ADV22433.1 - 1.3e-63 214.5 0.0 1.7e-63 214.1 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 ADV22433.1 - 2.1e-15 56.5 0.0 4.3e-15 55.5 0.0 1.5 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain Chol_subst-bind PF09129.11 ADV22433.1 - 0.15 11.0 0.0 0.23 10.4 0.0 1.2 1 0 0 1 1 1 0 Cholesterol oxidase, substrate-binding RIBIOP_C PF04950.12 ADV22434.1 - 1.5e-115 385.6 0.0 2.3e-115 385.0 0.0 1.3 1 0 0 1 1 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 ADV22434.1 - 6.6e-14 51.8 0.0 1.3e-13 50.8 0.0 1.6 1 0 0 1 1 1 1 AARP2CN (NUC121) domain Telomerase_RBD PF12009.8 ADV22435.1 - 6e-27 94.4 1.3 2.2e-26 92.6 0.8 2.3 2 0 0 2 2 2 1 Telomerase ribonucleoprotein complex - RNA binding domain RVT_1 PF00078.27 ADV22435.1 - 2.2e-14 53.5 0.1 9.5e-11 41.6 0.0 2.5 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) TERT_thumb PF17984.1 ADV22435.1 - 0.059 13.2 1.0 0.13 12.1 1.0 1.5 1 0 0 1 1 1 0 Telomerase reverse transcriptase thumb DNA binding domain Glyoxalase_2 PF12681.7 ADV22435.1 - 0.061 13.3 0.1 0.16 11.9 0.1 1.6 1 0 0 1 1 1 0 Glyoxalase-like domain S4 PF01479.25 ADV22436.1 - 5e-11 42.1 1.7 5e-11 42.1 1.7 2.8 3 0 0 3 3 3 1 S4 domain Ribosomal_S4 PF00163.19 ADV22436.1 - 9.3e-07 29.7 0.8 1.4e-06 29.2 0.4 1.6 1 1 1 2 2 2 1 Ribosomal protein S4/S9 N-terminal domain DUF89 PF01937.19 ADV22439.1 - 5.5e-113 377.5 0.0 6.3e-113 377.3 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF89 UPRTase PF14681.6 ADV22440.1 - 4e-81 271.4 0.0 5e-81 271.1 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 ADV22440.1 - 0.00026 20.6 0.0 0.00034 20.1 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain zf-CCHC PF00098.23 ADV22441.1 - 1.8e-52 173.2 57.4 1.6e-08 34.2 4.0 7.2 7 0 0 7 7 7 7 Zinc knuckle zf-CCHC_3 PF13917.6 ADV22441.1 - 7.7e-13 48.2 40.0 0.09 12.8 1.8 7.1 4 2 3 7 7 7 7 Zinc knuckle zf-CCHC_4 PF14392.6 ADV22441.1 - 4.4e-12 45.5 37.9 0.11 12.3 0.3 7.1 7 0 0 7 7 7 7 Zinc knuckle zf-CCHC_6 PF15288.6 ADV22441.1 - 0.013 15.4 48.8 0.079 12.8 0.7 7.3 4 2 3 7 7 7 0 Zinc knuckle zf-CCHC_2 PF13696.6 ADV22441.1 - 0.085 12.7 52.2 0.17 11.7 2.1 7.3 7 0 0 7 7 7 0 Zinc knuckle zf-CCHC_5 PF14787.6 ADV22441.1 - 0.36 10.6 43.2 0.13 11.9 1.1 7.0 6 1 1 7 7 7 0 GAG-polyprotein viral zinc-finger RNA_pol_Rpb2_3 PF04565.16 ADV22441.1 - 1.7 8.9 5.6 0.28 11.4 0.7 2.2 2 0 0 2 2 2 0 RNA polymerase Rpb2, domain 3 DUF1275 PF06912.11 ADV22442.1 - 3.9e-24 85.7 18.3 4.5e-24 85.4 18.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1275) EamA PF00892.20 ADV22444.1 - 5.4e-06 26.6 7.9 5.4e-06 26.6 7.9 3.1 4 0 0 4 4 4 2 EamA-like transporter family PUNUT PF16913.5 ADV22444.1 - 0.004 16.4 1.9 0.004 16.4 1.9 1.9 2 1 0 2 2 2 1 Purine nucleobase transmembrane transport CSG2 PF16965.5 ADV22444.1 - 0.044 12.7 3.3 0.054 12.5 2.4 1.6 1 1 0 1 1 1 0 Ceramide synthase regulator GTA_holin_3TM PF11351.8 ADV22445.1 - 0.36 11.4 0.0 0.36 11.4 0.0 2.5 3 0 0 3 3 3 0 Holin of 3TMs, for gene-transfer release WD40 PF00400.32 ADV22446.1 - 1.2e-13 51.3 1.1 7e-07 29.8 0.0 3.6 3 0 0 3 3 3 2 WD domain, G-beta repeat FAD_binding_8 PF08022.12 ADV22446.1 - 0.48 10.5 2.4 61 3.8 0.2 3.3 3 0 0 3 3 3 0 FAD-binding domain DUF498 PF04430.14 ADV22447.1 - 1.9e-30 105.1 0.0 2.5e-30 104.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF498/DUF598) F-box-like PF12937.7 ADV22449.1 - 8.2e-09 35.2 0.1 1.7e-08 34.2 0.1 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ADV22449.1 - 0.0096 15.8 0.1 0.023 14.6 0.1 1.7 1 0 0 1 1 1 1 F-box domain WD40 PF00400.32 ADV22449.1 - 0.014 16.2 0.0 1.1 10.3 0.3 3.2 2 0 0 2 2 2 0 WD domain, G-beta repeat Glyco_hydro_18 PF00704.28 ADV22450.1 - 9.3e-15 55.1 2.7 2e-14 54.1 2.7 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Nup188 PF10487.9 ADV22451.1 - 0.49 8.2 1.7 0.72 7.7 1.7 1.1 1 0 0 1 1 1 0 Nucleoporin subcomplex protein binding to Pom34 DUF3099 PF11298.8 ADV22451.1 - 2.3 8.4 4.9 1.4 9.1 1.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3099) Ribosomal_L2_C PF03947.18 ADV22452.1 - 1.2e-45 154.8 3.3 2.4e-45 153.8 1.8 2.4 2 1 0 2 2 2 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 ADV22452.1 - 8.9e-20 70.4 1.2 8e-19 67.4 1.2 2.5 1 1 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain PIG-F PF06699.11 ADV22453.1 - 2.6e-30 105.9 2.9 4.7e-30 105.1 2.9 1.5 1 1 0 1 1 1 1 GPI biosynthesis protein family Pig-F ParA PF10609.9 ADV22454.1 - 6.6e-76 255.0 0.4 8.1e-76 254.7 0.4 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 ADV22454.1 - 8.5e-10 38.8 0.0 3.1e-09 37.0 0.0 1.8 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 ADV22454.1 - 4.9e-07 29.8 0.8 5.2e-06 26.5 0.9 2.0 1 1 0 1 1 1 1 AAA domain MipZ PF09140.11 ADV22454.1 - 0.00014 21.2 0.1 0.00048 19.5 0.0 1.7 2 0 0 2 2 2 1 ATPase MipZ AAA_25 PF13481.6 ADV22454.1 - 0.00015 21.4 0.3 0.00031 20.4 0.0 1.5 2 0 0 2 2 2 1 AAA domain ArsA_ATPase PF02374.15 ADV22454.1 - 0.00036 19.8 1.0 0.0014 17.9 0.4 2.0 2 0 0 2 2 2 1 Anion-transporting ATPase NB-ARC PF00931.22 ADV22454.1 - 0.073 12.3 0.0 0.1 11.7 0.0 1.1 1 0 0 1 1 1 0 NB-ARC domain RNA_helicase PF00910.22 ADV22454.1 - 0.16 12.3 0.0 0.28 11.6 0.0 1.3 1 0 0 1 1 1 0 RNA helicase PhoH PF02562.16 ADV22454.1 - 0.2 11.1 0.0 0.33 10.4 0.0 1.2 1 0 0 1 1 1 0 PhoH-like protein Aminotran_3 PF00202.21 ADV22455.1 - 8.8e-101 337.5 0.0 1e-100 337.2 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III DNA_ligase_IV PF11411.8 ADV22455.1 - 0.042 14.0 0.0 0.1 12.7 0.0 1.6 1 0 0 1 1 1 0 DNA ligase IV Ras PF00071.22 ADV22456.1 - 8.2e-64 214.1 0.5 9.7e-64 213.8 0.5 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ADV22456.1 - 2.3e-35 121.4 0.1 3.5e-35 120.8 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ADV22456.1 - 1.4e-13 50.7 0.1 1.7e-13 50.4 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ADV22456.1 - 9.3e-08 32.2 0.1 1.3e-07 31.7 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ADV22456.1 - 1.7e-05 24.8 0.2 0.017 15.0 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 ADV22456.1 - 9e-05 22.1 0.3 0.0003 20.4 0.3 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 ADV22456.1 - 0.0022 17.4 0.1 0.0031 16.9 0.1 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_22 PF13401.6 ADV22456.1 - 0.0037 17.5 0.0 0.034 14.4 0.0 2.2 1 1 0 1 1 1 1 AAA domain SRPRB PF09439.10 ADV22456.1 - 0.005 16.3 0.0 0.0093 15.4 0.0 1.4 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit FeoB_N PF02421.18 ADV22456.1 - 0.011 15.3 0.5 0.083 12.4 0.5 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B PduV-EutP PF10662.9 ADV22456.1 - 0.013 15.2 0.0 0.028 14.2 0.0 1.9 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.6 ADV22456.1 - 0.017 15.5 0.1 0.028 14.8 0.1 1.5 1 1 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 ADV22456.1 - 0.02 15.4 0.2 0.034 14.7 0.1 1.5 1 1 0 1 1 1 0 ABC transporter AEP1 PF17049.5 ADV22456.1 - 0.023 13.8 0.0 0.031 13.4 0.0 1.1 1 0 0 1 1 1 0 ATPase expression protein 1 AAA_14 PF13173.6 ADV22456.1 - 0.025 14.6 0.1 0.064 13.3 0.1 1.7 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 ADV22456.1 - 0.035 13.8 0.1 0.082 12.6 0.1 1.8 1 1 0 1 1 1 0 AAA domain TniB PF05621.11 ADV22456.1 - 0.041 13.3 0.0 0.23 10.8 0.0 1.9 2 0 0 2 2 2 0 Bacterial TniB protein MCM PF00493.23 ADV22456.1 - 0.089 11.9 0.0 0.17 10.9 0.0 1.6 1 1 0 1 1 1 0 MCM P-loop domain AAA_7 PF12775.7 ADV22456.1 - 0.13 11.8 0.0 0.29 10.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF4265 PF14085.6 ADV22456.1 - 0.13 12.3 0.0 3.2 7.7 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4265) AAA_21 PF13304.6 ADV22456.1 - 0.18 11.6 0.7 0.32 10.8 0.6 1.5 1 1 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system RNase_T PF00929.24 ADV22457.1 - 1.3e-14 55.1 0.0 1.3e-11 45.3 0.0 2.4 2 0 0 2 2 2 2 Exonuclease SAP PF02037.27 ADV22457.1 - 1.4e-07 31.1 1.5 2.4e-07 30.3 1.5 1.5 1 0 0 1 1 1 1 SAP domain DUF572 PF04502.13 ADV22458.1 - 9.8e-67 225.9 0.0 1.1e-66 225.8 0.0 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF572) Sec1 PF00995.23 ADV22459.1 - 3.5e-116 389.7 0.0 3.9e-116 389.6 0.0 1.0 1 0 0 1 1 1 1 Sec1 family DUF1629 PF07791.11 ADV22459.1 - 0.087 13.0 0.0 0.21 11.7 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1629) Syja_N PF02383.18 ADV22460.1 - 1.6e-78 264.3 0.1 3.1e-78 263.3 0.1 1.5 1 0 0 1 1 1 1 SacI homology domain Mrr_N PF14338.6 ADV22460.1 - 0.091 12.9 0.1 0.27 11.4 0.1 1.8 1 0 0 1 1 1 0 Mrr N-terminal domain Ribosomal_L7Ae PF01248.26 ADV22461.1 - 3.7e-21 74.7 1.6 3.7e-21 74.7 1.6 1.9 2 0 0 2 2 2 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.11 ADV22461.1 - 0.0066 16.5 0.0 0.0094 16.0 0.0 1.3 1 0 0 1 1 1 1 RNase P subunit Pop3 T6SS_Vgr PF13296.6 ADV22461.1 - 0.028 14.5 1.0 0.066 13.3 0.0 2.1 3 0 0 3 3 3 0 Putative type VI secretion system Rhs element Vgr DUF5427 PF10310.9 ADV22461.1 - 0.081 11.9 9.3 0.12 11.3 9.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) CENP-H PF05837.12 ADV22461.1 - 0.69 10.3 6.3 0.63 10.5 3.2 2.1 2 0 0 2 2 2 0 Centromere protein H (CENP-H) RhoGEF PF00621.20 ADV22462.1 - 4.9e-19 69.3 0.0 7.1e-19 68.7 0.0 1.3 1 0 0 1 1 1 1 RhoGEF domain Methyltransf_15 PF09445.10 ADV22463.1 - 1.8e-38 131.7 0.0 2.5e-38 131.3 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_25 PF13649.6 ADV22463.1 - 2e-08 34.9 0.0 3.1e-07 31.0 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 ADV22463.1 - 1.1e-07 31.8 0.0 2.4e-07 30.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.16 ADV22463.1 - 3.7e-06 26.8 0.0 5.8e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein Cons_hypoth95 PF03602.15 ADV22463.1 - 4.6e-06 26.4 0.0 1.4e-05 24.8 0.0 1.7 1 1 1 2 2 2 1 Conserved hypothetical protein 95 UPF0020 PF01170.18 ADV22463.1 - 7.3e-05 22.5 0.2 0.00055 19.7 0.0 2.3 2 1 0 2 2 2 1 Putative RNA methylase family UPF0020 Methyltransf_11 PF08241.12 ADV22463.1 - 0.00016 22.3 0.0 0.0033 18.1 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain CTNNB1_binding PF08347.11 ADV22463.1 - 0.0046 17.2 1.0 0.0078 16.4 1.0 1.4 1 0 0 1 1 1 1 N-terminal CTNNB1 binding MTS PF05175.14 ADV22463.1 - 0.005 16.4 0.0 0.011 15.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_5 PF01795.19 ADV22463.1 - 0.016 14.7 0.0 0.026 14.0 0.0 1.3 1 0 0 1 1 1 0 MraW methylase family Methyltransf_3 PF01596.17 ADV22463.1 - 0.021 14.0 0.1 0.048 12.8 0.0 1.5 2 0 0 2 2 2 0 O-methyltransferase Methyltransf_18 PF12847.7 ADV22463.1 - 0.057 13.3 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain PrmA PF06325.13 ADV22463.1 - 0.059 12.7 0.3 0.12 11.8 0.0 1.5 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_24 PF13578.6 ADV22463.1 - 0.096 13.7 0.0 0.32 12.0 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain CmcI PF04989.12 ADV22463.1 - 0.14 11.8 0.0 0.3 10.8 0.0 1.5 1 0 0 1 1 1 0 Cephalosporin hydroxylase tRNA_U5-meth_tr PF05958.11 ADV22463.1 - 0.24 10.4 0.0 0.36 9.8 0.0 1.2 1 0 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase Acetyltransf_1 PF00583.25 ADV22464.1 - 4.2e-05 23.8 0.0 0.00011 22.4 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ADV22464.1 - 0.0013 19.1 0.0 0.027 14.9 0.0 2.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 ADV22464.1 - 0.0046 17.6 0.0 0.054 14.2 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 ADV22464.1 - 0.0099 16.0 0.0 0.023 14.8 0.0 1.5 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_10 PF13673.7 ADV22464.1 - 0.17 11.8 0.0 3.2 7.7 0.0 2.5 2 1 0 2 2 2 0 Acetyltransferase (GNAT) domain SH3_1 PF00018.28 ADV22466.1 - 2.4e-05 23.8 0.0 4.2e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ADV22466.1 - 0.0024 17.7 0.0 0.0052 16.6 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Polyketide_cyc PF03364.20 ADV22468.1 - 4.1e-17 62.6 0.0 6.2e-17 62.0 0.0 1.3 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Goodbye PF17109.5 ADV22469.1 - 0.072 13.5 0.0 0.22 12.0 0.0 1.7 2 0 0 2 2 2 0 fungal STAND N-terminal Goodbye domain HEPN_AbiU2 PF18734.1 ADV22469.1 - 0.1 12.1 0.0 0.2 11.1 0.0 1.4 1 0 0 1 1 1 0 AbiU2 RhoGEF PF00621.20 ADV22470.1 - 0.03 14.5 0.0 0.065 13.5 0.0 1.5 1 0 0 1 1 1 0 RhoGEF domain DUF1604 PF07713.13 ADV22471.1 - 5.8e-39 131.8 2.6 5.8e-39 131.8 2.6 3.2 3 1 0 3 3 3 1 Protein of unknown function (DUF1604) G-patch PF01585.23 ADV22471.1 - 8e-06 25.7 0.2 8e-06 25.7 0.2 2.1 2 0 0 2 2 2 1 G-patch domain Rnk_N PF14760.6 ADV22471.1 - 0.0048 17.4 0.0 0.011 16.2 0.0 1.6 1 0 0 1 1 1 1 Rnk N-terminus Red1 PF07964.11 ADV22471.1 - 4.5 5.4 18.1 7 4.8 18.1 1.2 1 0 0 1 1 1 0 Rec10 / Red1 V_ATPase_I PF01496.19 ADV22471.1 - 9.9 3.9 11.8 15 3.3 11.8 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family HsbA PF12296.8 ADV22472.1 - 0.0062 16.9 4.5 5.4 7.5 0.1 3.8 2 1 2 4 4 4 3 Hydrophobic surface binding protein A Baculo_p24 PF05073.12 ADV22472.1 - 0.027 14.3 0.8 0.027 14.3 0.8 2.8 2 1 2 4 4 4 0 Baculovirus P24 capsid protein XH PF03469.14 ADV22472.1 - 0.031 14.2 0.5 0.031 14.2 0.5 3.3 2 1 1 3 3 3 0 XH domain DUF3800 PF12686.7 ADV22472.1 - 0.048 14.3 0.4 3.9 8.1 0.6 2.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) DUF948 PF06103.11 ADV22472.1 - 0.071 13.4 4.5 7.8 6.8 0.0 4.1 4 1 0 4 4 4 0 Bacterial protein of unknown function (DUF948) DUF4407 PF14362.6 ADV22472.1 - 0.98 8.7 35.5 0.91 8.8 16.5 3.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4407) ABC_tran_CTD PF16326.5 ADV22472.1 - 4.2 7.7 43.0 0.1 12.9 5.3 6.6 5 1 2 7 7 7 0 ABC transporter C-terminal domain Nre_C PF04895.12 ADV22474.1 - 0.063 13.2 0.0 0.77 9.7 0.0 2.4 2 0 0 2 2 2 0 Archaeal Nre, C-terminal PrmA PF06325.13 ADV22475.1 - 2.1e-13 50.3 0.1 3.5e-13 49.6 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 ADV22475.1 - 8.7e-12 45.6 0.0 2.2e-11 44.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ADV22475.1 - 7.6e-11 42.5 0.0 2e-10 41.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ADV22475.1 - 3e-10 40.1 0.0 5.8e-10 39.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ADV22475.1 - 1.4e-07 31.2 0.1 2.7e-07 30.3 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_18 PF12847.7 ADV22475.1 - 1.1e-06 28.7 0.0 2.3e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ADV22475.1 - 4.9e-06 26.5 0.0 1.4e-05 25.0 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Met_10 PF02475.16 ADV22475.1 - 6.4e-06 26.0 0.2 1.1e-05 25.3 0.2 1.3 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_12 PF08242.12 ADV22475.1 - 1.4e-05 25.8 0.0 2.9e-05 24.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 ADV22475.1 - 0.00031 20.5 0.1 0.00052 19.8 0.1 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Cons_hypoth95 PF03602.15 ADV22475.1 - 0.00092 18.9 0.0 0.0015 18.2 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_9 PF08003.11 ADV22475.1 - 0.0021 17.0 0.0 0.0031 16.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) CMAS PF02353.20 ADV22475.1 - 0.0027 17.0 0.0 0.0048 16.2 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_32 PF13679.6 ADV22475.1 - 0.021 14.8 0.0 0.042 13.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Pinin_SDK_N PF04697.13 ADV22475.1 - 0.037 14.7 0.2 0.079 13.6 0.2 1.5 1 0 0 1 1 1 0 pinin/SDK conserved region UPF0020 PF01170.18 ADV22475.1 - 0.051 13.2 0.3 0.11 12.1 0.3 1.6 1 1 0 1 1 1 0 Putative RNA methylase family UPF0020 SusE PF14292.6 ADV22475.1 - 0.064 13.5 0.0 0.57 10.4 0.0 2.4 2 0 0 2 2 2 0 SusE outer membrane protein TehB PF03848.14 ADV22475.1 - 0.068 12.6 0.3 0.25 10.7 0.1 1.9 1 1 1 2 2 2 0 Tellurite resistance protein TehB Methyltransf_24 PF13578.6 ADV22475.1 - 0.075 14.1 0.0 0.18 12.9 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain GidB PF02527.15 ADV22475.1 - 0.076 12.3 0.1 0.18 11.1 0.0 1.7 1 1 1 2 2 2 0 rRNA small subunit methyltransferase G MetW PF07021.12 ADV22475.1 - 0.085 12.4 0.5 0.56 9.8 0.2 2.1 1 1 1 2 2 2 0 Methionine biosynthesis protein MetW GCD14 PF08704.10 ADV22475.1 - 0.16 11.6 0.0 0.29 10.8 0.0 1.3 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit DUF1667 PF07892.11 ADV22475.1 - 0.29 11.2 1.5 0.55 10.3 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1667) Ribonucleas_3_3 PF14622.6 ADV22476.1 - 6.1e-16 58.8 0.0 1.2e-15 57.8 0.0 1.5 1 1 0 1 1 1 1 Ribonuclease-III-like Ribonuclease_3 PF00636.26 ADV22476.1 - 0.063 13.9 0.0 0.17 12.5 0.0 1.7 1 1 0 1 1 1 0 Ribonuclease III domain DUF3336 PF11815.8 ADV22477.1 - 7.1e-45 152.1 1.5 1.1e-44 151.6 1.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.22 ADV22477.1 - 3.3e-19 69.9 0.1 7.6e-19 68.7 0.1 1.7 1 0 0 1 1 1 1 Patatin-like phospholipase HTH_38 PF13936.6 ADV22477.1 - 0.13 12.0 0.1 0.31 10.9 0.1 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain FKBP_C PF00254.28 ADV22479.1 - 2.4e-34 117.5 0.0 3e-34 117.2 0.0 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Fungal_trans_2 PF11951.8 ADV22480.1 - 1.1e-34 119.9 0.0 1.4e-34 119.5 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ADV22480.1 - 2.5e-06 27.5 10.1 4.4e-06 26.7 10.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain HA2 PF04408.23 ADV22481.1 - 6.4e-22 77.9 0.0 6.4e-22 77.9 0.0 3.3 4 0 0 4 4 3 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 ADV22481.1 - 6.6e-15 55.2 0.0 1.7e-14 53.9 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 ADV22481.1 - 5.9e-13 49.1 0.0 1.2e-12 48.1 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 ADV22481.1 - 1.2e-07 31.6 0.0 2.4e-07 30.7 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 ADV22481.1 - 0.00032 21.0 1.4 0.0023 18.2 1.4 2.2 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 ADV22481.1 - 0.003 17.3 0.0 0.0083 15.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 ADV22481.1 - 0.0055 17.0 0.1 0.012 15.9 0.1 1.5 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 ADV22481.1 - 0.008 15.5 0.0 0.016 14.4 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) IstB_IS21 PF01695.17 ADV22481.1 - 0.011 15.5 0.1 3.3 7.4 0.0 2.4 2 0 0 2 2 2 0 IstB-like ATP binding protein T2SSE PF00437.20 ADV22481.1 - 0.023 13.7 0.0 0.061 12.4 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein ResIII PF04851.15 ADV22481.1 - 0.05 13.6 0.0 3.3 7.7 0.0 2.4 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit ATPase PF06745.13 ADV22481.1 - 0.15 11.4 0.1 0.31 10.4 0.1 1.4 1 0 0 1 1 1 0 KaiC AAA_14 PF13173.6 ADV22481.1 - 0.17 11.9 0.2 1.1 9.3 0.2 2.1 1 1 0 1 1 1 0 AAA domain Kelch_5 PF13854.6 ADV22482.1 - 4.9e-15 55.1 6.9 1.1e-06 28.5 0.0 5.3 5 0 0 5 5 5 4 Kelch motif Kelch_4 PF13418.6 ADV22482.1 - 3.2e-09 36.6 13.8 0.016 15.2 0.0 5.8 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_3 PF13415.6 ADV22482.1 - 7.9e-05 22.8 23.8 0.053 13.8 0.0 6.5 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_6 PF13964.6 ADV22482.1 - 0.0064 16.8 11.1 0.14 12.4 0.6 4.8 5 1 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 ADV22482.1 - 0.019 14.5 8.6 1.6 8.4 0.0 5.0 5 0 0 5 5 5 0 Kelch motif MFS_1 PF07690.16 ADV22483.1 - 1e-47 162.8 29.8 5.2e-32 111.1 11.5 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 ADV22483.1 - 2.3e-07 30.0 20.2 0.0024 16.8 6.1 3.3 2 1 0 2 2 2 2 MFS_1 like family MFS_4 PF06779.14 ADV22483.1 - 5.4e-05 22.6 12.6 0.00013 21.4 3.5 2.6 2 0 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB MFS_3 PF05977.13 ADV22483.1 - 0.00024 19.6 12.0 0.0022 16.5 2.3 2.5 3 0 0 3 3 3 2 Transmembrane secretion effector OATP PF03137.20 ADV22483.1 - 0.00097 17.5 0.1 0.00097 17.5 0.1 3.6 3 2 1 4 4 4 2 Organic Anion Transporter Polypeptide (OATP) family RCR PF12273.8 ADV22484.1 - 7.3 7.3 7.3 42 4.8 7.3 2.1 1 1 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red PfkB PF00294.24 ADV22485.1 - 1.6e-30 106.4 0.2 7.6e-30 104.2 0.2 1.9 1 1 0 1 1 1 1 pfkB family carbohydrate kinase AIRC PF00731.20 ADV22486.1 - 9.7e-65 216.7 0.7 2.1e-64 215.6 0.7 1.6 1 0 0 1 1 1 1 AIR carboxylase ATP-grasp PF02222.22 ADV22486.1 - 1.4e-50 171.3 0.0 2.2e-50 170.6 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain PurK_C PF17769.1 ADV22486.1 - 1.2e-19 69.8 0.2 2.3e-19 68.8 0.2 1.5 1 0 0 1 1 1 1 Phosphoribosylaminoimidazole carboxylase C-terminal domain Dala_Dala_lig_C PF07478.13 ADV22486.1 - 0.0026 17.3 0.0 0.034 13.7 0.0 2.3 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus PrpR_N PF06506.11 ADV22486.1 - 0.0052 16.4 0.1 0.03 13.9 0.0 2.1 2 0 0 2 2 2 1 Propionate catabolism activator ATP-grasp_3 PF02655.14 ADV22486.1 - 0.064 13.3 0.1 0.27 11.3 0.0 2.1 2 1 0 2 2 2 0 ATP-grasp domain DUF3277 PF11681.8 ADV22486.1 - 0.11 12.4 0.0 5.7 6.8 0.0 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3277) HMA PF00403.26 ADV22487.1 - 0.0026 18.2 0.0 0.0047 17.3 0.0 1.4 1 0 0 1 1 1 1 Heavy-metal-associated domain DASH_Dam1 PF08653.10 ADV22488.1 - 1.2e-22 79.4 0.1 1.9e-22 78.8 0.1 1.2 1 0 0 1 1 1 1 DASH complex subunit Dam1 NAPRTase_N PF17767.1 ADV22488.1 - 0.025 14.9 0.0 0.028 14.8 0.0 1.1 1 0 0 1 1 1 0 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain Ras PF00071.22 ADV22489.1 - 1.4e-51 174.3 0.0 1.8e-51 174.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ADV22489.1 - 1.8e-30 105.6 0.0 2.8e-30 105.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ADV22489.1 - 5e-12 45.6 0.0 6.7e-12 45.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ADV22489.1 - 0.00036 20.0 0.0 0.0005 19.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region ATP_bind_1 PF03029.17 ADV22489.1 - 0.0016 18.3 0.0 0.0046 16.8 0.0 1.6 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.27 ADV22489.1 - 0.0026 17.3 0.0 0.0047 16.5 0.0 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ADV22489.1 - 0.004 17.2 0.0 0.0072 16.4 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_7 PF12775.7 ADV22489.1 - 0.016 14.7 0.0 0.026 14.0 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_16 PF13191.6 ADV22489.1 - 0.034 14.5 0.1 0.065 13.6 0.1 1.7 1 1 0 1 1 1 0 AAA ATPase domain Rad51 PF08423.11 ADV22489.1 - 0.065 12.5 0.1 7.3 5.8 0.0 2.1 2 0 0 2 2 2 0 Rad51 Mito_carr PF00153.27 ADV22490.1 - 8.8e-67 221.1 2.4 4.1e-22 77.9 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF2428 PF10350.9 ADV22491.1 - 1.1e-48 165.9 0.1 2e-48 165.0 0.1 1.5 1 0 0 1 1 1 1 Putative death-receptor fusion protein (DUF2428) HEAT_2 PF13646.6 ADV22491.1 - 0.02 15.3 6.5 1.5 9.2 0.0 5.5 6 1 0 6 6 6 0 HEAT repeats HEAT_EZ PF13513.6 ADV22491.1 - 0.06 13.9 0.1 9.6 6.8 0.0 4.4 3 0 0 3 3 3 0 HEAT-like repeat E1_dh PF00676.20 ADV22492.1 - 2.9e-88 295.7 0.0 3.5e-88 295.4 0.0 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.21 ADV22492.1 - 0.31 10.8 1.6 0.52 10.1 0.1 2.1 3 0 0 3 3 3 0 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Glyco_hydro_15 PF00723.21 ADV22493.1 - 9.6e-60 202.6 0.0 1.2e-59 202.3 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 DUF1168 PF06658.12 ADV22494.1 - 2e-41 141.0 11.3 3.1e-41 140.4 11.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1168) LPD15 PF18828.1 ADV22494.1 - 0.041 13.7 0.1 0.073 12.9 0.1 1.3 1 0 0 1 1 1 0 Large polyvalent-protein-associated domain 15 Lyase_catalyt PF09093.11 ADV22494.1 - 0.075 12.2 0.0 0.11 11.6 0.0 1.1 1 0 0 1 1 1 0 Lyase, catalytic Atrophin-1 PF03154.15 ADV22494.1 - 0.92 7.7 12.3 1.3 7.2 12.3 1.2 1 0 0 1 1 1 0 Atrophin-1 family BRF1 PF07741.13 ADV22494.1 - 2.6 8.5 10.5 1.2 9.5 7.8 1.9 1 1 1 2 2 2 0 Brf1-like TBP-binding domain Ribosomal_L3 PF00297.22 ADV22495.1 - 6.4e-23 81.3 4.7 2e-20 73.1 1.7 2.4 2 1 1 3 3 3 2 Ribosomal protein L3 Palm_thioest PF02089.15 ADV22496.1 - 3.2e-05 23.9 0.0 4.5e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Palmitoyl protein thioesterase DUF676 PF05057.14 ADV22496.1 - 6.6e-05 22.5 0.0 0.00015 21.3 0.0 1.6 1 1 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.13 ADV22496.1 - 0.083 12.6 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 PGAP1-like protein Abhydrolase_1 PF00561.20 ADV22498.1 - 9.2e-36 123.8 0.3 2.4e-33 115.9 0.1 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Esterase PF00756.20 ADV22498.1 - 0.0055 16.4 0.1 0.011 15.4 0.1 1.5 1 0 0 1 1 1 1 Putative esterase Hydrolase_4 PF12146.8 ADV22498.1 - 0.077 12.2 0.2 7.9 5.7 0.1 2.2 2 0 0 2 2 2 0 Serine aminopeptidase, S33 WD40 PF00400.32 ADV22499.1 - 6.6e-19 67.9 13.5 4.8e-05 24.0 0.9 6.1 5 1 1 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV22499.1 - 5.6e-09 36.2 0.0 1.1 9.6 0.0 5.0 3 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 ADV22499.1 - 0.0034 17.3 1.5 0.67 10.0 0.0 2.6 2 0 0 2 2 2 2 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 ADV22499.1 - 0.0073 15.3 0.1 7.7 5.4 0.0 3.4 3 1 0 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ADV22499.1 - 0.057 12.1 0.2 0.18 10.4 0.1 1.6 1 1 1 2 2 2 0 Nucleoporin Nup120/160 MRP-S32 PF10210.9 ADV22499.1 - 0.081 13.5 0.0 0.17 12.5 0.0 1.5 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S32 Frtz PF11768.8 ADV22499.1 - 0.23 9.8 0.0 3.5 5.8 0.0 2.4 3 0 0 3 3 3 0 WD repeat-containing and planar cell polarity effector protein Fritz Oxidored_q6 PF01058.22 ADV22500.1 - 2.7e-22 79.0 0.1 3.9e-22 78.5 0.1 1.2 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit Xpo1 PF08389.12 ADV22501.1 - 1.4e-31 109.6 0.0 9e-31 107.0 0.0 2.5 3 0 0 3 3 3 1 Exportin 1-like protein AFG1_ATPase PF03969.16 ADV22502.1 - 7.6e-51 173.1 0.0 5.2e-27 94.7 0.0 3.5 2 1 1 3 3 3 3 AFG1-like ATPase AAA_16 PF13191.6 ADV22502.1 - 2.1e-06 28.2 0.1 1.6e-05 25.3 0.1 2.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 ADV22502.1 - 0.0054 16.7 0.0 0.013 15.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ADV22502.1 - 0.0076 16.5 0.0 0.031 14.6 0.0 2.0 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 ADV22502.1 - 0.01 15.2 0.0 0.022 14.1 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_29 PF13555.6 ADV22502.1 - 0.013 15.3 0.0 0.033 13.9 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 ADV22502.1 - 0.018 15.5 0.0 0.044 14.3 0.0 1.7 1 0 0 1 1 1 0 ABC transporter AAA_18 PF13238.6 ADV22502.1 - 0.022 15.3 0.0 0.053 14.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 ADV22502.1 - 0.045 14.2 0.0 0.57 10.6 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 ADV22502.1 - 0.064 12.5 0.0 0.13 11.5 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_14 PF13173.6 ADV22502.1 - 0.073 13.1 0.0 0.28 11.2 0.0 2.0 3 0 0 3 3 3 0 AAA domain T2SSE PF00437.20 ADV22502.1 - 0.084 11.9 0.0 0.14 11.2 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_30 PF13604.6 ADV22502.1 - 0.17 11.6 0.0 0.33 10.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 ADV22503.1 - 8e-49 165.7 0.3 3e-27 95.8 0.0 2.9 4 0 0 4 4 2 2 ABC transporter ABC_membrane PF00664.23 ADV22503.1 - 1.2e-26 94.0 19.4 8.6e-16 58.4 1.1 3.5 3 0 0 3 3 3 2 ABC transporter transmembrane region SMC_N PF02463.19 ADV22503.1 - 9.6e-06 25.2 0.7 0.14 11.5 0.0 3.8 2 2 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 ADV22503.1 - 0.00015 22.0 0.4 1.6 9.0 0.0 3.6 3 0 0 3 3 3 2 AAA domain AAA_29 PF13555.6 ADV22503.1 - 0.0008 19.1 0.6 1.9 8.3 0.0 2.8 3 0 0 3 3 3 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 ADV22503.1 - 0.0028 17.6 0.0 0.43 10.5 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_25 PF13481.6 ADV22503.1 - 0.0032 17.1 0.1 2.2 7.8 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_23 PF13476.6 ADV22503.1 - 0.0034 17.9 0.5 4.6 7.7 0.0 2.9 3 0 0 3 3 3 2 AAA domain AAA_14 PF13173.6 ADV22503.1 - 0.0054 16.8 0.1 2.7 8.0 0.0 3.4 2 1 0 3 3 3 1 AAA domain AAA_16 PF13191.6 ADV22503.1 - 0.013 15.9 0.0 0.41 11.0 0.0 3.1 3 0 0 3 3 3 0 AAA ATPase domain T2SSE PF00437.20 ADV22503.1 - 0.019 14.0 0.0 0.15 11.1 0.0 2.1 2 0 0 2 2 2 0 Type II/IV secretion system protein ATPase PF06745.13 ADV22503.1 - 0.029 13.7 0.2 8.1 5.7 0.0 2.5 2 0 0 2 2 2 0 KaiC AAA_21 PF13304.6 ADV22503.1 - 0.036 13.9 0.4 32 4.2 0.0 3.8 4 0 0 4 4 4 0 AAA domain, putative AbiEii toxin, Type IV TA system TrwB_AAD_bind PF10412.9 ADV22503.1 - 0.045 12.6 0.2 0.17 10.7 0.0 1.9 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_33 PF13671.6 ADV22503.1 - 0.16 12.1 0.0 30 4.8 0.0 2.9 3 0 0 3 3 3 0 AAA domain NB-ARC PF00931.22 ADV22503.1 - 0.28 10.3 1.8 1.5 8.0 0.1 2.7 3 1 0 3 3 3 0 NB-ARC domain XAP5 PF04921.14 ADV22504.1 - 1e-85 287.6 6.1 1e-85 287.6 6.1 1.9 1 1 1 2 2 2 1 XAP5, circadian clock regulator TRCF PF03461.15 ADV22504.1 - 0.043 14.2 0.4 0.17 12.3 0.2 2.0 2 0 0 2 2 2 0 TRCF domain FAD-SLDH PF12318.8 ADV22504.1 - 0.3 11.1 3.2 0.55 10.3 3.2 1.4 1 0 0 1 1 1 0 Membrane bound FAD containing D-sorbitol dehydrogenase Med19 PF10278.9 ADV22504.1 - 1.1 9.2 14.7 0.25 11.3 6.8 2.4 2 1 0 2 2 2 0 Mediator of RNA pol II transcription subunit 19 Dus PF01207.17 ADV22505.1 - 1.1e-45 156.1 0.0 2.8e-45 154.7 0.0 1.6 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) RimK PF08443.11 ADV22505.1 - 0.18 11.4 0.2 0.58 9.7 0.0 1.8 2 0 0 2 2 2 0 RimK-like ATP-grasp domain Ras PF00071.22 ADV22506.1 - 1e-44 152.0 0.0 1.2e-44 151.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ADV22506.1 - 9.3e-25 87.2 0.0 1.5e-24 86.6 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ADV22506.1 - 4.9e-07 29.4 0.0 6.7e-07 28.9 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family DUF5118 PF17162.4 ADV22506.1 - 0.071 12.9 0.1 0.14 12.0 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5118) Gtr1_RagA PF04670.12 ADV22506.1 - 0.071 12.4 0.0 0.084 12.2 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region STAS PF01740.21 ADV22506.1 - 0.13 11.9 0.0 0.29 10.8 0.0 1.6 1 1 0 1 1 1 0 STAS domain VID27 PF08553.10 ADV22507.1 - 4.1e-167 555.7 0.1 5.6e-167 555.2 0.1 1.2 1 0 0 1 1 1 1 VID27 C-terminal WD40-like domain VID27_N PF17748.1 ADV22507.1 - 3.1e-61 206.2 0.0 3.1e-61 206.2 0.0 2.3 2 0 0 2 2 2 1 VID27 N-terminal region VID27_PH PF17747.1 ADV22507.1 - 2.2e-17 63.3 0.0 6.3e-16 58.6 0.0 2.5 2 0 0 2 2 2 1 VID27 PH-like domain WD40 PF00400.32 ADV22507.1 - 0.059 14.3 0.0 21 6.2 0.0 2.9 2 1 0 2 2 2 0 WD domain, G-beta repeat DNA_pol_phi PF04931.13 ADV22507.1 - 3.2 5.7 8.3 5.1 5.1 8.3 1.2 1 0 0 1 1 1 0 DNA polymerase phi Nop53 PF07767.11 ADV22507.1 - 9.7 5.5 11.8 19 4.5 11.8 1.4 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) zf-CCHC_6 PF15288.6 ADV22508.1 - 0.008 16.0 0.3 0.024 14.4 0.3 1.8 1 0 0 1 1 1 1 Zinc knuckle Mak10 PF04112.13 ADV22509.1 - 2.7e-40 137.6 0.1 4.7e-40 136.9 0.1 1.4 1 0 0 1 1 1 1 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase CBM_1 PF00734.18 ADV22509.1 - 0.094 12.7 0.2 0.19 11.7 0.2 1.5 1 0 0 1 1 1 0 Fungal cellulose binding domain LEA_2 PF03168.13 ADV22510.1 - 0.00043 20.8 0.0 0.00085 19.8 0.0 1.5 1 0 0 1 1 1 1 Late embryogenesis abundant protein Vac7 PF12751.7 ADV22510.1 - 0.14 11.6 0.0 0.23 10.9 0.0 1.3 1 0 0 1 1 1 0 Vacuolar segregation subunit 7 GST_N_3 PF13417.6 ADV22511.1 - 2.2e-19 69.7 0.0 5.5e-18 65.1 0.0 2.5 1 1 1 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 ADV22511.1 - 3.4e-07 30.5 0.0 7.4e-07 29.4 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 ADV22511.1 - 4.4e-06 27.0 0.0 9.8e-06 25.8 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Glyco_H_20C_C PF18088.1 ADV22511.1 - 0.021 14.7 0.1 0.032 14.1 0.1 1.2 1 0 0 1 1 1 0 Glycoside Hydrolase 20C C-terminal domain Wtap PF17098.5 ADV22511.1 - 0.13 12.2 0.8 0.22 11.5 0.8 1.5 1 1 0 1 1 1 0 WTAP/Mum2p family 60KD_IMP PF02096.20 ADV22512.1 - 3.8e-25 88.7 1.6 5.2e-25 88.3 1.6 1.2 1 0 0 1 1 1 1 60Kd inner membrane protein Scramblase PF03803.15 ADV22513.1 - 1.2e-46 158.8 0.0 1.6e-46 158.4 0.0 1.1 1 0 0 1 1 1 1 Scramblase Brr6_like_C_C PF10104.9 ADV22514.1 - 1.7e-43 147.6 4.3 2.2e-43 147.2 4.3 1.1 1 0 0 1 1 1 1 Di-sulfide bridge nucleocytoplasmic transport domain Peptidase_S49_N PF08496.10 ADV22514.1 - 5.8 7.0 5.7 2.5 8.2 0.1 2.3 2 0 0 2 2 2 0 Peptidase family S49 N-terminal ANAPC4_WD40 PF12894.7 ADV22515.1 - 1.3e-05 25.4 0.0 0.091 13.1 0.0 3.4 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ADV22515.1 - 0.019 15.8 1.7 0.58 11.1 0.0 3.5 4 1 0 4 4 4 0 WD domain, G-beta repeat CNH PF00780.22 ADV22515.1 - 0.028 14.0 0.1 0.38 10.3 0.1 2.5 2 1 1 3 3 3 0 CNH domain PGBA_N PF15436.6 ADV22515.1 - 0.21 11.2 0.0 1.2 8.7 0.0 2.0 2 0 0 2 2 2 0 Plasminogen-binding protein pgbA N-terminal Sugar_tr PF00083.24 ADV22516.1 - 1.2e-114 383.7 21.7 1.7e-114 383.2 21.7 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ADV22516.1 - 5.8e-34 117.6 37.9 1.5e-29 103.0 24.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 ADV22516.1 - 0.00021 19.9 4.1 0.00021 19.9 4.1 2.0 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) MFS_1_like PF12832.7 ADV22516.1 - 0.00022 20.2 9.6 0.059 12.2 3.2 3.2 2 1 1 3 3 3 2 MFS_1 like family Phage_holin_3_2 PF04550.12 ADV22516.1 - 0.39 11.3 2.9 1.5 9.5 2.9 2.0 1 0 0 1 1 1 0 Phage holin family 2 OST3_OST6 PF04756.13 ADV22516.1 - 0.63 9.3 6.9 0.28 10.5 2.1 2.3 2 0 0 2 2 2 0 OST3 / OST6 family, transporter family PI-PLC-X PF00388.19 ADV22517.1 - 0.043 13.4 0.0 0.087 12.4 0.0 1.5 1 0 0 1 1 1 0 Phosphatidylinositol-specific phospholipase C, X domain Sel1 PF08238.12 ADV22518.1 - 1.4e-41 140.0 16.5 4.6e-07 30.3 0.5 7.4 7 0 0 7 7 7 7 Sel1 repeat TPR_19 PF14559.6 ADV22518.1 - 2.1 8.9 5.4 4.7 7.8 0.1 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat Ndc80_HEC PF03801.13 ADV22519.1 - 1.2e-42 145.1 0.0 2.8e-42 144.0 0.0 1.6 1 0 0 1 1 1 1 HEC/Ndc80p family DUF5595 PF18077.1 ADV22519.1 - 0.00039 20.4 1.4 0.00039 20.4 1.4 2.7 3 0 0 3 3 3 1 Domain of unknown function (DUF5595) Golgin_A5 PF09787.9 ADV22519.1 - 0.003 17.1 27.7 0.13 11.7 5.2 2.4 2 0 0 2 2 2 2 Golgin subfamily A member 5 HAUS-augmin3 PF14932.6 ADV22519.1 - 0.0098 15.5 4.6 0.0098 15.5 4.6 3.2 2 1 1 3 3 3 1 HAUS augmin-like complex subunit 3 Flu_NS2 PF00601.19 ADV22519.1 - 0.041 14.2 5.0 1.1 9.6 0.7 3.3 2 2 0 3 3 3 0 Influenza non-structural protein (NS2) TFIIA PF03153.13 ADV22520.1 - 0.32 10.9 27.7 0.59 10.1 27.7 1.5 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Peptidase_M14 PF00246.24 ADV22521.1 - 4.6e-64 217.0 0.0 6.1e-64 216.6 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.16 ADV22521.1 - 0.016 15.6 0.1 0.028 14.8 0.1 1.4 1 0 0 1 1 1 0 Carboxypeptidase activation peptide NDK PF00334.19 ADV22522.1 - 8.1e-54 181.3 0.0 9.4e-54 181.1 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase G-patch PF01585.23 ADV22523.1 - 3.7e-09 36.3 1.5 7.6e-09 35.3 1.5 1.6 1 0 0 1 1 1 1 G-patch domain FHA PF00498.26 ADV22523.1 - 7.9e-08 32.5 0.1 2.3e-07 31.1 0.0 1.8 2 0 0 2 2 2 1 FHA domain G-patch_2 PF12656.7 ADV22523.1 - 0.00019 21.4 1.0 0.00048 20.2 1.0 1.7 1 0 0 1 1 1 1 G-patch domain CDC73_C PF05179.14 ADV22524.1 - 1.1e-54 184.3 2.4 1.7e-54 183.8 2.4 1.3 1 0 0 1 1 1 1 RNA pol II accessory factor, Cdc73 family, C-terminal CDC73_N PF16050.5 ADV22524.1 - 0.012 14.9 0.1 3.1 7.0 0.3 2.2 2 0 0 2 2 2 0 Paf1 complex subunit CDC73 N-terminal TPP1 PF10341.9 ADV22525.1 - 3.3e-07 30.3 0.0 1.1e-06 28.6 0.0 1.9 1 0 0 1 1 1 1 Shelterin complex subunit, TPP1/ACD APH PF01636.23 ADV22526.1 - 1.1e-27 97.5 0.0 1.7e-27 96.9 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 ADV22526.1 - 9.8e-05 21.8 0.0 0.00015 21.2 0.0 1.4 1 1 0 1 1 1 1 Ecdysteroid kinase Choline_kinase PF01633.20 ADV22526.1 - 0.027 14.1 0.0 0.043 13.4 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase DUF1679 PF07914.11 ADV22526.1 - 0.13 11.1 0.0 0.24 10.2 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1679) NPC1_N PF16414.5 ADV22527.1 - 1.2e-79 267.3 8.1 2.2e-79 266.5 8.1 1.4 1 0 0 1 1 1 1 Niemann-Pick C1 N terminus Patched PF02460.18 ADV22527.1 - 1e-73 248.8 2.4 6.1e-39 133.8 0.1 3.3 3 0 0 3 3 3 3 Patched family Sterol-sensing PF12349.8 ADV22527.1 - 4e-43 146.9 8.2 4e-43 146.9 8.2 4.0 3 2 0 3 3 3 1 Sterol-sensing domain of SREBP cleavage-activation ACR_tran PF00873.19 ADV22527.1 - 0.0018 16.0 4.5 0.0018 16.0 4.5 1.5 2 0 0 2 2 2 1 AcrB/AcrD/AcrF family DUF5051 PF16473.5 ADV22527.1 - 0.13 12.2 0.1 0.26 11.2 0.1 1.4 1 0 0 1 1 1 0 3' exoribonuclease, RNase T-like La PF05383.17 ADV22528.1 - 8.7e-19 67.3 0.0 2.1e-18 66.1 0.0 1.6 1 0 0 1 1 1 1 La domain RRM_1 PF00076.22 ADV22528.1 - 0.00072 19.3 0.6 0.0066 16.2 0.6 2.5 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 ADV22528.1 - 0.16 12.0 2.8 0.71 10.0 0.2 2.8 3 0 0 3 3 3 0 RNA binding motif MutL_C PF08676.11 ADV22529.1 - 0.081 12.7 0.1 1.1 9.0 0.2 2.1 2 0 0 2 2 2 0 MutL C terminal dimerisation domain MoCF_biosynth PF00994.24 ADV22530.1 - 2.2e-31 108.5 0.0 6.1e-31 107.0 0.0 1.8 1 1 0 1 1 1 1 Probable molybdopterin binding domain PALP PF00291.25 ADV22531.1 - 7.8e-68 229.0 0.2 8.7e-68 228.9 0.2 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme SMC_hinge PF06470.13 ADV22531.1 - 0.0026 18.1 0.1 0.0052 17.1 0.1 1.6 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain DUF3074 PF11274.8 ADV22532.1 - 9.2e-41 139.8 0.5 3.1e-40 138.1 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3074) CK_II_beta PF01214.18 ADV22533.1 - 2.6e-81 271.8 0.0 3.4e-81 271.4 0.0 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit Mod_r PF07200.13 ADV22534.1 - 8.8e-33 113.5 0.8 1.1e-32 113.2 0.8 1.1 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein Hpt PF01627.23 ADV22534.1 - 0.0095 16.2 0.4 0.029 14.6 0.4 1.8 1 0 0 1 1 1 1 Hpt domain SPX PF03105.19 ADV22534.1 - 0.085 12.8 2.4 0.11 12.4 2.4 1.1 1 0 0 1 1 1 0 SPX domain MBOAT_2 PF13813.6 ADV22535.1 - 3.5e-06 27.2 4.3 0.13 12.5 0.0 2.9 2 0 0 2 2 2 2 Membrane bound O-acyl transferase family Rieske PF00355.26 ADV22536.1 - 4.7e-09 36.1 0.6 4.6e-08 32.9 0.6 2.2 1 1 0 1 1 1 1 Rieske [2Fe-2S] domain UCR_TM PF02921.14 ADV22536.1 - 5.3e-07 30.0 2.8 5.3e-07 30.0 2.8 1.9 2 1 0 2 2 2 1 Ubiquinol cytochrome reductase transmembrane region VWA_2 PF13519.6 ADV22537.1 - 0.00021 21.9 0.0 0.0005 20.7 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain vWA-TerF-like PF10138.9 ADV22537.1 - 0.0097 16.0 0.0 0.017 15.3 0.0 1.3 1 0 0 1 1 1 1 vWA found in TerF C terminus VWA PF00092.28 ADV22537.1 - 0.067 13.4 0.0 0.13 12.5 0.0 1.5 1 1 0 1 1 1 0 von Willebrand factor type A domain SR-25 PF10500.9 ADV22538.1 - 0.00013 21.6 26.4 0.0003 20.5 26.4 1.5 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Apt1 PF10351.9 ADV22538.1 - 0.19 10.5 11.9 0.28 10.0 11.9 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain SBE2 PF17076.5 ADV22538.1 - 0.63 8.2 10.9 0.93 7.6 10.9 1.1 1 0 0 1 1 1 0 SBE2, cell-wall formation Zip PF02535.22 ADV22538.1 - 0.71 9.0 5.0 1.2 8.3 5.0 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter DUF4551 PF15087.6 ADV22538.1 - 2.9 6.6 8.8 4.5 6.0 8.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Metallophos PF00149.28 ADV22539.1 - 2.9e-33 116.1 0.2 3.6e-33 115.8 0.2 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ADV22539.1 - 0.059 13.6 0.0 0.085 13.0 0.0 1.3 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain STPPase_N PF16891.5 ADV22539.1 - 0.069 13.6 0.2 0.17 12.3 0.2 1.7 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain Ribosomal_L6e PF01159.19 ADV22540.1 - 3.8e-40 136.9 2.2 6.7e-40 136.1 0.2 2.0 2 0 0 2 2 2 1 Ribosomal protein L6e Ribosomal_L6e_N PF03868.15 ADV22540.1 - 0.00031 20.9 0.2 0.0017 18.5 0.1 2.3 2 0 0 2 2 2 1 Ribosomal protein L6, N-terminal domain Paf1 PF03985.13 ADV22541.1 - 6.7e-59 200.0 1.1 7.6e-59 199.8 1.1 1.0 1 0 0 1 1 1 1 Paf1 PPTA PF01239.22 ADV22542.1 - 1.2e-28 98.0 19.6 2.8e-06 26.9 0.1 5.3 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat TPR_2 PF07719.17 ADV22542.1 - 0.00035 20.5 0.8 0.26 11.5 0.0 3.3 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 ADV22542.1 - 0.001 19.0 1.0 0.06 13.4 0.1 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 ADV22542.1 - 0.0058 17.3 1.0 6 8.0 0.1 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 ADV22542.1 - 0.013 16.2 0.1 1.9 9.2 0.1 3.0 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.6 ADV22542.1 - 0.022 15.3 0.1 1.1 9.8 0.0 2.9 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 ADV22542.1 - 0.029 15.0 1.7 0.48 11.2 0.1 2.7 2 1 0 2 2 2 0 Tetratricopeptide repeat Complex1_LYR PF05347.15 ADV22544.1 - 0.00023 21.2 0.8 0.00029 20.8 0.8 1.2 1 0 0 1 1 1 1 Complex 1 protein (LYR family) HXXSHH PF07586.11 ADV22544.1 - 0.018 14.6 0.1 0.019 14.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1552) Cellulase PF00150.18 ADV22545.1 - 3.7e-09 36.4 13.6 3e-08 33.4 13.6 2.4 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Sortilin-Vps10 PF15902.5 ADV22546.1 - 4.4e-275 912.3 4.9 3.3e-137 457.9 0.3 2.5 2 1 0 2 2 2 2 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 ADV22546.1 - 1.8e-95 318.1 18.5 6.7e-51 173.0 4.7 2.4 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, C-terminal PSII_BNR PF14870.6 ADV22546.1 - 1.1e-06 28.1 2.3 0.2 10.9 0.1 4.1 4 0 0 4 4 4 2 Photosynthesis system II assembly factor YCF48 BNR PF02012.20 ADV22546.1 - 1.3e-05 24.5 49.7 0.8 9.9 0.1 11.5 11 0 0 11 11 11 4 BNR/Asp-box repeat CHB_HEX_C PF03174.13 ADV22546.1 - 1.4e-05 25.0 3.5 2.3 8.2 0.0 6.0 5 1 1 6 6 6 2 Chitobiase/beta-hexosaminidase C-terminal domain BNR_2 PF13088.6 ADV22546.1 - 5.5e-05 22.6 7.3 1.6 8.0 0.0 6.0 5 2 0 5 5 5 2 BNR repeat-like domain Fe_dep_repr_C PF02742.15 ADV22546.1 - 0.081 13.0 0.0 0.33 11.1 0.0 1.9 2 0 0 2 2 2 0 Iron dependent repressor, metal binding and dimerisation domain Zip PF02535.22 ADV22547.1 - 9.7e-19 67.8 4.4 3.2e-18 66.0 4.4 1.7 1 1 0 1 1 1 1 ZIP Zinc transporter zf-RING_2 PF13639.6 ADV22548.1 - 1.2e-12 48.0 5.0 1.2e-12 48.0 5.0 2.0 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 ADV22548.1 - 1.8e-09 37.3 4.9 1.8e-09 37.3 4.9 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ADV22548.1 - 2.4e-08 33.5 2.4 5.2e-08 32.5 2.4 1.6 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_UBOX PF13445.6 ADV22548.1 - 1.7e-07 31.1 4.5 4.1e-07 29.9 4.5 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.7 ADV22548.1 - 3.5e-07 30.4 4.9 9.4e-07 29.0 4.9 1.7 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 ADV22548.1 - 8e-07 28.8 7.0 3.4e-06 26.8 1.9 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ADV22548.1 - 1.1e-06 28.4 3.3 1.1e-06 28.4 3.3 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ADV22548.1 - 3.3e-06 26.9 1.6 3.3e-06 26.9 1.6 2.1 2 0 0 2 2 2 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 ADV22548.1 - 0.00041 20.3 1.4 0.00082 19.4 1.4 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 ADV22548.1 - 0.00059 19.6 6.5 0.00059 19.6 6.5 2.6 2 1 1 3 3 2 1 Prokaryotic RING finger family 4 Zn_ribbon_17 PF17120.5 ADV22548.1 - 0.0025 17.4 1.6 0.0055 16.3 1.6 1.5 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zinc_ribbon_9 PF14369.6 ADV22548.1 - 0.0063 16.7 0.9 0.0063 16.7 0.9 2.9 3 0 0 3 3 3 1 zinc-ribbon Rad50_zn_hook PF04423.14 ADV22548.1 - 0.031 14.1 0.2 6.7 6.6 0.0 2.5 2 0 0 2 2 2 0 Rad50 zinc hook motif DZR PF12773.7 ADV22548.1 - 0.17 11.9 5.2 0.73 9.9 0.4 2.7 2 1 0 2 2 2 0 Double zinc ribbon Tmemb_cc2 PF10267.9 ADV22548.1 - 0.31 10.1 2.9 0.44 9.6 2.9 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein zf-C3HC4_4 PF15227.6 ADV22548.1 - 0.88 9.8 6.0 2.5 8.3 6.0 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING PHD PF00628.29 ADV22548.1 - 1.1 9.2 6.4 0.8 9.6 2.1 2.5 2 0 0 2 2 2 0 PHD-finger HypA PF01155.19 ADV22548.1 - 1.3 9.0 3.1 2.3 8.2 0.1 2.2 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-TFIIB PF13453.6 ADV22548.1 - 1.5 8.2 8.2 18 4.8 1.1 3.3 3 0 0 3 3 3 0 Transcription factor zinc-finger FANCL_C PF11793.8 ADV22548.1 - 1.6 9.0 5.2 24 5.2 5.3 2.7 1 1 1 2 2 2 0 FANCL C-terminal domain zf-RING_2 PF13639.6 ADV22549.1 - 4.6e-07 30.1 9.4 9.1e-07 29.1 9.4 1.5 1 0 0 1 1 1 1 Ring finger domain FANCL_C PF11793.8 ADV22549.1 - 0.00021 21.4 4.6 0.00045 20.3 4.6 1.5 1 0 0 1 1 1 1 FANCL C-terminal domain zf-ANAPC11 PF12861.7 ADV22549.1 - 0.009 16.0 2.2 0.017 15.1 2.2 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 ADV22549.1 - 0.0098 16.2 7.1 0.02 15.2 7.1 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain Zn_ribbon_17 PF17120.5 ADV22549.1 - 0.045 13.4 5.2 0.095 12.3 5.2 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-C3HC4_2 PF13923.6 ADV22549.1 - 0.049 13.5 8.1 0.1 12.4 8.1 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) CPL PF08144.11 ADV22549.1 - 0.081 13.3 0.0 1 9.7 0.0 2.9 3 0 0 3 3 3 0 CPL (NUC119) domain RINGv PF12906.7 ADV22549.1 - 0.12 12.5 6.8 0.22 11.7 6.8 1.5 1 0 0 1 1 1 0 RING-variant domain zf-C3HC4 PF00097.25 ADV22549.1 - 0.13 12.2 9.3 0.24 11.3 9.3 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING-like PF08746.11 ADV22549.1 - 0.26 11.6 7.0 0.48 10.8 7.0 1.5 1 0 0 1 1 1 0 RING-like domain C1_1 PF00130.22 ADV22549.1 - 0.88 9.5 3.6 0.48 10.3 1.4 1.6 1 1 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Zf_RING PF16744.5 ADV22549.1 - 0.94 9.6 3.3 2.4 8.4 3.3 1.6 1 0 0 1 1 1 0 KIAA1045 RING finger UQ_con PF00179.26 ADV22550.1 - 6.4e-14 51.8 0.0 9.4e-14 51.2 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme zf-RanBP PF00641.18 ADV22550.1 - 0.029 13.7 0.1 0.029 13.7 0.1 1.9 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others Rubredoxin PF00301.20 ADV22550.1 - 0.052 13.6 0.1 0.12 12.4 0.1 1.6 1 0 0 1 1 1 0 Rubredoxin AraC_binding PF02311.19 ADV22550.1 - 0.15 11.9 0.0 0.31 10.9 0.0 1.5 1 0 0 1 1 1 0 AraC-like ligand binding domain PCI PF01399.27 ADV22551.1 - 1.3e-08 35.3 0.0 1.3e-08 35.3 0.0 2.9 4 0 0 4 4 4 1 PCI domain YojJ PF10372.9 ADV22551.1 - 5.3 7.2 6.0 14 5.9 0.3 3.2 2 0 0 2 2 2 0 Bacterial membrane-spanning protein N-terminus Nop PF01798.18 ADV22553.1 - 1.3e-88 296.4 0.0 1.3e-88 296.4 0.0 2.0 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 ADV22553.1 - 2.6e-19 69.4 0.1 1.2e-18 67.2 0.1 2.3 1 0 0 1 1 1 1 NOP5NT (NUC127) domain DUF3349 PF11829.8 ADV22553.1 - 1.1 10.1 4.5 14 6.5 2.1 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF3349) Ribonuc_red_lgC PF02867.15 ADV22554.1 - 1.5e-185 617.7 0.0 2e-185 617.3 0.0 1.2 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 ADV22554.1 - 2.8e-25 88.1 0.1 6.9e-25 86.9 0.1 1.7 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 ADV22554.1 - 4.1e-15 56.1 0.1 1.6e-14 54.2 0.0 2.1 2 0 0 2 2 2 1 ATP cone domain HEAT PF02985.22 ADV22555.1 - 1.4e-09 37.4 6.3 0.31 11.4 0.0 6.6 6 0 0 6 6 6 3 HEAT repeat Importin_rep_4 PF18808.1 ADV22555.1 - 9e-08 32.3 0.2 5.5e-07 29.8 0.1 2.4 2 1 1 3 3 3 1 Importin repeat HEAT_EZ PF13513.6 ADV22555.1 - 1.7e-07 31.6 7.2 6.2e-06 26.6 0.1 5.4 6 0 0 6 6 6 1 HEAT-like repeat HEAT_2 PF13646.6 ADV22555.1 - 2.2e-07 31.2 0.9 0.00011 22.6 0.6 3.9 2 1 2 4 4 4 2 HEAT repeats Vac14_Fab1_bd PF12755.7 ADV22555.1 - 5.4e-05 23.7 0.0 2 9.0 0.0 4.6 4 1 1 5 5 5 2 Vacuolar 14 Fab1-binding region DUF4042 PF13251.6 ADV22555.1 - 0.00083 19.1 0.1 10 5.8 0.0 3.9 2 1 1 3 3 3 2 Domain of unknown function (DUF4042) Cnd1 PF12717.7 ADV22555.1 - 0.0035 17.4 0.0 2.2 8.3 0.0 2.7 2 0 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 V-ATPase_H_N PF03224.14 ADV22555.1 - 0.031 13.6 0.2 0.064 12.5 0.2 1.5 1 1 0 1 1 1 0 V-ATPase subunit H DUF3385 PF11865.8 ADV22555.1 - 0.063 13.2 0.0 18 5.2 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3385) RIX1 PF08167.12 ADV22555.1 - 0.3 10.8 0.9 17 5.0 0.0 2.8 3 0 0 3 3 3 0 rRNA processing/ribosome biogenesis Gly_transf_sug PF04488.15 ADV22556.1 - 1.2e-06 29.1 0.0 2e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif TcdA_TcdB PF12919.7 ADV22556.1 - 0.19 11.0 0.1 0.28 10.4 0.1 1.1 1 0 0 1 1 1 0 TcdA/TcdB catalytic glycosyltransferase domain Peptidase_M76 PF09768.9 ADV22557.1 - 7.8e-74 247.1 1.6 9.2e-74 246.9 1.6 1.0 1 0 0 1 1 1 1 Peptidase M76 family SprT-like PF10263.9 ADV22557.1 - 0.016 15.1 0.5 0.027 14.3 0.5 1.4 1 0 0 1 1 1 0 SprT-like family Peptidase_M13 PF01431.21 ADV22557.1 - 0.1 12.2 0.1 0.15 11.6 0.1 1.2 1 0 0 1 1 1 0 Peptidase family M13 Tox-MPTase2 PF15638.6 ADV22557.1 - 0.13 12.0 0.1 0.18 11.5 0.1 1.1 1 0 0 1 1 1 0 Metallopeptidase toxin 2 Septin PF00735.18 ADV22558.1 - 5.5e-109 363.8 0.1 1e-108 362.9 0.0 1.4 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 ADV22558.1 - 0.0012 18.9 0.0 0.0049 16.9 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase FtsK_SpoIIIE PF01580.18 ADV22558.1 - 0.0015 17.9 0.2 0.0033 16.8 0.2 1.5 1 0 0 1 1 1 1 FtsK/SpoIIIE family AAA_16 PF13191.6 ADV22558.1 - 0.012 16.0 0.5 0.035 14.5 0.0 1.9 2 1 0 2 2 2 0 AAA ATPase domain GTP_EFTU PF00009.27 ADV22558.1 - 0.012 15.2 0.0 0.43 10.1 0.0 2.6 2 1 0 3 3 3 0 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 ADV22558.1 - 0.036 14.4 0.0 0.13 12.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 ADV22558.1 - 0.045 13.7 4.0 0.26 11.2 0.9 3.1 3 1 0 3 3 3 0 RsgA GTPase DUF87 PF01935.17 ADV22558.1 - 0.096 12.8 1.0 0.93 9.5 0.0 2.2 2 0 0 2 2 2 0 Helicase HerA, central domain IIGP PF05049.13 ADV22558.1 - 0.12 11.4 0.1 0.27 10.3 0.1 1.5 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) AIG1 PF04548.16 ADV22558.1 - 0.13 11.6 0.6 3.4 6.9 0.6 2.4 1 1 0 1 1 1 0 AIG1 family Dynamin_N PF00350.23 ADV22558.1 - 0.25 11.4 3.8 13 5.8 0.0 3.0 2 1 0 3 3 3 0 Dynamin family AAA PF00004.29 ADV22559.1 - 3.8e-13 50.0 0.0 1.4e-12 48.2 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ADV22559.1 - 5.4e-09 36.7 0.5 8e-07 29.6 0.1 3.0 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 ADV22559.1 - 1.7e-06 28.3 0.0 3.8e-06 27.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_lid_10 PF17872.1 ADV22559.1 - 0.00013 22.0 0.0 0.00038 20.5 0.0 1.7 1 0 0 1 1 1 1 AAA lid domain DUF2075 PF09848.9 ADV22559.1 - 0.0053 16.0 0.0 0.0093 15.2 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_19 PF13245.6 ADV22559.1 - 0.0074 16.6 0.1 0.014 15.8 0.1 1.4 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 ADV22559.1 - 0.064 13.2 0.0 1.5 8.7 0.0 2.2 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_7 PF12775.7 ADV22559.1 - 0.079 12.5 0.0 5.2 6.5 0.0 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_3 PF07726.11 ADV22559.1 - 0.11 12.4 0.1 14 5.6 0.0 2.5 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.15 ADV22559.1 - 0.13 12.2 0.1 0.48 10.3 0.1 1.9 2 0 0 2 2 2 0 NTPase YL1 PF05764.13 ADV22559.1 - 0.14 12.3 10.3 0.11 12.6 5.2 2.0 2 0 0 2 2 2 0 YL1 nuclear protein TIP49 PF06068.13 ADV22559.1 - 0.14 11.3 0.0 0.25 10.5 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain Spindle_Spc25 PF08234.12 ADV22560.1 - 3.1e-24 84.9 0.3 1.1e-23 83.2 0.2 2.0 2 0 0 2 2 2 1 Chromosome segregation protein Spc25 zf-C4H2 PF10146.9 ADV22560.1 - 0.009 16.3 0.4 0.012 16.0 0.4 1.3 1 0 0 1 1 1 1 Zinc finger-containing protein AAA_13 PF13166.6 ADV22560.1 - 0.038 12.6 5.5 0.049 12.3 5.5 1.0 1 0 0 1 1 1 0 AAA domain Spc7 PF08317.11 ADV22560.1 - 0.067 12.1 12.2 0.098 11.5 12.2 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein PIEZO PF15917.5 ADV22560.1 - 0.21 11.0 4.8 0.3 10.5 4.8 1.2 1 0 0 1 1 1 0 Piezo Prominin PF05478.11 ADV22560.1 - 0.22 9.5 3.3 0.27 9.1 3.3 1.1 1 0 0 1 1 1 0 Prominin Sec8_exocyst PF04048.14 ADV22560.1 - 0.39 10.6 6.7 0.15 12.0 0.8 2.1 1 1 1 2 2 2 0 Sec8 exocyst complex component specific domain CENP-F_leu_zip PF10473.9 ADV22560.1 - 1.5 8.9 16.2 4.4 7.3 16.1 1.7 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TMPIT PF07851.13 ADV22560.1 - 2.1 7.5 6.7 3 7.0 6.7 1.2 1 0 0 1 1 1 0 TMPIT-like protein KxDL PF10241.9 ADV22560.1 - 2.4 8.5 7.4 3.3 8.0 5.6 2.1 1 1 1 2 2 2 0 Uncharacterized conserved protein FAM76 PF16046.5 ADV22560.1 - 2.4 7.5 7.2 3.3 7.0 7.2 1.2 1 0 0 1 1 1 0 FAM76 protein OmpH PF03938.14 ADV22560.1 - 2.5 8.5 15.1 1 9.7 6.1 2.2 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) YabA PF06156.13 ADV22560.1 - 6.1 7.5 6.4 7.3 7.3 5.1 1.7 1 1 0 1 1 1 0 Initiation control protein YabA APG6_N PF17675.1 ADV22560.1 - 6.6 7.3 14.7 19 5.8 14.7 1.7 1 1 0 1 1 1 0 Apg6 coiled-coil region Cmc1 PF08583.10 ADV22561.1 - 2.6e-16 59.4 1.5 3.3e-16 59.1 1.5 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like CENP-B_N PF04218.13 ADV22561.1 - 0.026 14.1 0.2 0.089 12.4 0.0 1.8 2 0 0 2 2 2 0 CENP-B N-terminal DNA-binding domain NDUF_B7 PF05676.13 ADV22561.1 - 0.055 13.2 0.2 0.083 12.6 0.2 1.3 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) DUF3128 PF11326.8 ADV22561.1 - 0.47 10.8 4.6 1.7 9.0 4.6 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3128) Yip1 PF04893.17 ADV22563.1 - 5.4e-16 58.8 16.6 7.8e-16 58.3 16.6 1.2 1 0 0 1 1 1 1 Yip1 domain Methyltr_RsmB-F PF01189.17 ADV22564.1 - 3.8e-26 92.0 0.0 7.7e-26 91.0 0.0 1.5 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Nop53 PF07767.11 ADV22564.1 - 0.14 11.5 11.2 0.3 10.4 11.2 1.5 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Epimerase PF01370.21 ADV22565.1 - 5.5e-17 62.0 0.0 9.4e-17 61.3 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ADV22565.1 - 5.6e-13 48.5 0.0 1.3e-12 47.3 0.0 1.6 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 ADV22565.1 - 4.6e-09 36.1 0.0 7.2e-09 35.5 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 ADV22565.1 - 5.5e-08 32.9 0.0 1.2e-07 31.8 0.0 1.6 1 1 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 ADV22565.1 - 1.4e-07 31.3 0.0 2.2e-07 30.7 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family NAD_binding_4 PF07993.12 ADV22565.1 - 7.9e-07 28.5 0.0 0.00059 19.1 0.0 2.2 2 0 0 2 2 2 2 Male sterility protein adh_short PF00106.25 ADV22565.1 - 0.0015 18.1 0.1 0.0029 17.1 0.1 1.6 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ADV22565.1 - 0.016 14.8 0.0 0.15 11.5 0.0 2.1 1 1 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 ADV22566.1 - 3.2e-13 49.7 0.0 8.1e-13 48.4 0.0 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ADV22566.1 - 1e-09 37.9 0.0 2.2e-09 36.8 0.0 1.4 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 ADV22566.1 - 6.2e-09 35.4 0.0 3e-07 29.9 0.0 2.1 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 ADV22566.1 - 7.2e-08 32.5 0.1 1e-07 32.0 0.1 1.2 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 ADV22566.1 - 1.8e-07 31.0 0.2 3.2e-07 30.2 0.2 1.4 1 0 0 1 1 1 1 NmrA-like family GDP_Man_Dehyd PF16363.5 ADV22566.1 - 2.5e-07 30.4 0.1 4.6e-07 29.6 0.0 1.4 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase adh_short PF00106.25 ADV22566.1 - 0.0016 17.9 0.3 0.0034 16.9 0.3 1.5 1 0 0 1 1 1 1 short chain dehydrogenase Sacchrp_dh_NADP PF03435.18 ADV22566.1 - 0.024 14.9 0.1 0.052 13.8 0.1 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain KR PF08659.10 ADV22566.1 - 0.043 13.7 0.1 0.17 11.7 0.1 1.9 1 1 0 1 1 1 0 KR domain Semialdhyde_dh PF01118.24 ADV22566.1 - 0.1 13.1 0.1 0.22 12.0 0.1 1.6 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain CitMHS PF03600.16 ADV22567.1 - 8e-33 113.9 50.3 2.4e-28 99.2 26.0 2.1 1 1 1 2 2 2 2 Citrate transporter Na_sulph_symp PF00939.19 ADV22567.1 - 1.1e-26 93.9 34.3 1.5e-26 93.5 34.3 1.1 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region SPX PF03105.19 ADV22567.1 - 1.2e-20 74.8 29.2 8.7e-15 55.5 23.2 3.6 1 1 1 2 2 2 2 SPX domain DUF1388 PF07142.12 ADV22567.1 - 0.49 10.4 1.6 1 9.4 1.6 1.4 1 0 0 1 1 1 0 Repeat of unknown function (DUF1388) Hemagglutinin PF00509.18 ADV22567.1 - 2.2 6.6 4.0 3.7 5.8 0.1 2.2 2 0 0 2 2 2 0 Haemagglutinin SRP54 PF00448.22 ADV22569.1 - 1.3e-73 246.8 0.3 2.3e-73 246.1 0.3 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 ADV22569.1 - 2.4e-26 92.2 0.2 2.4e-26 92.2 0.2 4.2 3 1 1 4 4 2 1 Signal peptide binding domain SRP54_N PF02881.19 ADV22569.1 - 3.2e-19 68.9 2.9 3.2e-19 68.9 2.9 1.8 2 0 0 2 2 1 1 SRP54-type protein, helical bundle domain AAA_33 PF13671.6 ADV22569.1 - 3.8e-05 23.9 0.1 0.0002 21.5 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 ADV22569.1 - 0.00025 20.8 0.3 0.0055 16.5 0.1 2.5 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 ADV22569.1 - 0.00032 20.3 0.4 0.0027 17.3 0.4 2.2 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CbiA PF01656.23 ADV22569.1 - 0.00048 20.2 0.0 0.0015 18.6 0.0 1.8 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MeaB PF03308.16 ADV22569.1 - 0.0018 17.3 1.0 0.014 14.4 0.5 2.6 2 1 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_17 PF13207.6 ADV22569.1 - 0.0029 18.0 1.4 0.011 16.1 0.0 2.7 3 0 0 3 3 2 1 AAA domain Thymidylate_kin PF02223.17 ADV22569.1 - 0.027 14.2 0.2 0.13 11.9 0.1 2.1 2 0 0 2 2 2 0 Thymidylate kinase Zeta_toxin PF06414.12 ADV22569.1 - 0.046 13.0 0.0 0.092 12.0 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin DUF1768 PF08719.11 ADV22569.1 - 0.047 13.9 0.0 0.097 12.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1768) MipZ PF09140.11 ADV22569.1 - 0.079 12.2 0.1 13 4.9 0.0 2.3 2 0 0 2 2 2 0 ATPase MipZ AAA_28 PF13521.6 ADV22569.1 - 0.11 12.8 0.0 0.23 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_31 PF13614.6 ADV22569.1 - 0.11 12.4 0.1 0.52 10.2 0.0 1.9 1 1 1 2 2 2 0 AAA domain ATP_bind_1 PF03029.17 ADV22569.1 - 0.11 12.2 0.1 0.28 10.9 0.1 1.7 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_18 PF13238.6 ADV22569.1 - 0.12 12.9 0.1 0.95 10.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 ADV22569.1 - 0.13 12.1 1.1 4 7.3 1.1 2.3 1 1 0 1 1 1 0 NTPase AAA_22 PF13401.6 ADV22569.1 - 0.15 12.3 0.0 0.38 11.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain ResIII PF04851.15 ADV22569.1 - 0.17 11.9 0.5 1.1 9.2 0.5 2.2 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit zf-UBR PF02207.20 ADV22570.1 - 3.5e-15 55.9 10.8 3.5e-15 55.9 10.8 2.5 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) ELL PF10390.9 ADV22570.1 - 2.2e-07 30.7 0.0 4.3e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase II elongation factor ELL zf-B_box PF00643.24 ADV22570.1 - 6.4 7.0 16.2 0.18 12.0 2.5 3.0 2 0 0 2 2 2 0 B-box zinc finger IMS PF00817.20 ADV22571.1 - 2.3e-30 105.6 0.0 3.2e-30 105.1 0.0 1.4 1 0 0 1 1 1 1 impB/mucB/samB family zf_UBZ PF18439.1 ADV22571.1 - 8.5e-09 34.9 3.4 2.3e-06 27.1 0.7 2.5 2 0 0 2 2 2 2 Ubiquitin-Binding Zinc Finger IMS_HHH PF11798.8 ADV22571.1 - 0.012 15.9 0.0 0.026 14.8 0.0 1.6 1 0 0 1 1 1 0 IMS family HHH motif 40S_S4_C PF16121.5 ADV22572.1 - 0.14 11.8 0.2 0.3 10.8 0.2 1.5 1 0 0 1 1 1 0 40S ribosomal protein S4 C-terminus Peptidase_S49_N PF08496.10 ADV22572.1 - 1.1 9.3 4.0 2 8.5 4.0 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal BTB PF00651.31 ADV22573.1 - 2.3e-05 24.6 0.0 0.0003 21.0 0.0 2.2 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.15 ADV22573.1 - 0.03 14.4 0.2 1.6 8.9 0.1 2.4 1 1 1 2 2 2 0 BTB And C-terminal Kelch TRAPP PF04051.16 ADV22574.1 - 1e-27 96.7 0.0 1.2e-27 96.5 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component XRN_M PF17846.1 ADV22575.1 - 5.7e-97 325.5 9.0 3.8e-96 322.7 9.0 2.1 1 1 0 1 1 1 1 Xrn1 helical domain XRN_N PF03159.18 ADV22575.1 - 1e-96 323.0 0.1 2.4e-96 321.8 0.0 1.7 2 0 0 2 2 2 1 XRN 5'-3' exonuclease N-terminus XRN1_D1 PF18332.1 ADV22575.1 - 1.3e-67 227.3 0.0 2.4e-67 226.4 0.0 1.5 1 0 0 1 1 1 1 Exoribonuclease Xrn1 D1 domain SH3_12 PF18129.1 ADV22575.1 - 1.5e-20 73.0 0.3 3.5e-20 71.9 0.3 1.7 1 0 0 1 1 1 1 Xrn1 SH3-like domain XRN1_D2_D3 PF18334.1 ADV22575.1 - 2.5e-18 66.0 0.0 8e-18 64.4 0.0 1.9 1 0 0 1 1 1 1 Exoribonuclease Xrn1 D2/D3 domain Metallophos PF00149.28 ADV22576.1 - 4.5e-36 125.3 0.7 6.1e-36 124.8 0.7 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 ADV22576.1 - 0.00042 20.7 0.0 0.0008 19.8 0.0 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Glyco_hydro_65N PF03636.15 ADV22576.1 - 0.049 13.2 0.0 0.076 12.6 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain Sec34 PF04136.15 ADV22577.1 - 1.1e-39 135.7 1.5 1.6e-39 135.1 0.1 2.0 2 0 0 2 2 2 1 Sec34-like family ZapD PF07072.11 ADV22577.1 - 0.14 11.9 0.5 0.35 10.6 0.5 1.7 1 0 0 1 1 1 0 Cell division protein FlgN PF05130.12 ADV22577.1 - 1.5 9.3 5.3 1 9.9 0.9 2.6 3 0 0 3 3 3 0 FlgN protein DUF21 PF01595.20 ADV22578.1 - 2.1e-35 122.0 0.0 3.1e-35 121.5 0.0 1.2 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain Autophagy_act_C PF03987.15 ADV22578.1 - 3.1e-13 50.1 0.1 8.1e-13 48.8 0.1 1.8 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain CBS PF00571.28 ADV22578.1 - 0.00016 22.1 0.0 0.12 12.8 0.0 3.0 3 0 0 3 3 3 2 CBS domain Virul_fac_BrkB PF03631.15 ADV22578.1 - 0.16 11.6 3.0 0.28 10.8 3.0 1.3 1 0 0 1 1 1 0 Virulence factor BrkB APC1_C PF18122.1 ADV22579.1 - 3.2e-21 76.0 0.0 6.9e-21 74.9 0.0 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex sub unit 1 C-terminal domain ANAPC1 PF12859.7 ADV22579.1 - 5.5e-17 62.5 0.1 1.2e-15 58.2 0.0 3.3 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 1 PC_rep PF01851.22 ADV22579.1 - 0.041 14.3 19.8 0.23 12.0 0.0 5.6 6 0 0 6 6 6 0 Proteasome/cyclosome repeat STE3 PF02076.15 ADV22579.1 - 0.14 11.3 0.0 0.22 10.7 0.0 1.2 1 0 0 1 1 1 0 Pheromone A receptor EF-hand_6 PF13405.6 ADV22580.1 - 5.8e-12 44.5 3.7 3.5e-07 29.6 0.1 3.4 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 ADV22580.1 - 7.1e-10 39.2 0.5 1.9e-07 31.4 0.5 2.4 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 ADV22580.1 - 2.8e-09 35.9 2.7 1.3e-06 27.5 0.2 3.8 4 0 0 4 4 4 1 EF hand EF-hand_5 PF13202.6 ADV22580.1 - 0.0005 19.4 3.2 0.00093 18.6 0.3 2.4 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 ADV22580.1 - 0.0058 16.5 4.4 0.96 9.3 0.3 3.4 2 2 2 4 4 4 3 EF-hand domain pair DUF2666 PF10869.8 ADV22580.1 - 0.07 13.3 0.0 0.15 12.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2666) Alpha-amylase PF00128.24 ADV22582.1 - 7.8e-53 180.2 0.0 1.1e-52 179.7 0.0 1.1 1 0 0 1 1 1 1 Alpha amylase, catalytic domain DUF1966 PF09260.11 ADV22582.1 - 2e-23 82.5 0.4 4.5e-23 81.3 0.4 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1966) Dehydrin PF00257.19 ADV22582.1 - 0.36 11.4 4.9 0.63 10.6 4.9 1.4 1 0 0 1 1 1 0 Dehydrin zf-DNL PF05180.12 ADV22583.1 - 3.5e-30 103.7 0.2 4.7e-30 103.3 0.2 1.2 1 0 0 1 1 1 1 DNL zinc finger Lar_restr_allev PF14354.6 ADV22583.1 - 0.077 13.4 0.6 0.54 10.7 0.2 2.1 1 1 2 3 3 3 0 Restriction alleviation protein Lar Zn-ribbon_8 PF09723.10 ADV22583.1 - 0.096 12.8 0.7 0.18 11.9 0.7 1.4 1 0 0 1 1 1 0 Zinc ribbon domain DUF4694 PF15765.5 ADV22584.1 - 0.005 16.9 0.1 0.01 15.9 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4694) Tox-MPTase3 PF15639.6 ADV22584.1 - 0.062 13.2 0.5 17 5.3 0.0 2.7 3 0 0 3 3 3 0 Metallopeptidase toxin 3 Pkinase PF00069.25 ADV22585.1 - 1.4e-57 195.1 0.0 4e-57 193.6 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV22585.1 - 1e-28 100.3 0.2 1e-19 70.9 0.1 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 ADV22585.1 - 2.6e-05 23.7 0.1 0.056 12.7 0.0 2.5 2 0 0 2 2 2 2 Kinase-like Haspin_kinase PF12330.8 ADV22585.1 - 0.01 14.8 0.0 0.016 14.1 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 ADV22585.1 - 0.02 14.8 2.4 0.079 12.9 0.1 2.5 2 1 1 3 3 3 0 Phosphotransferase enzyme family Kdo PF06293.14 ADV22585.1 - 0.045 13.1 0.0 0.082 12.2 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pinin_SDK_memA PF04696.13 ADV22586.1 - 2.2e-15 56.9 5.8 2.6e-14 53.4 3.7 3.8 3 1 0 3 3 3 2 pinin/SDK/memA/ protein conserved region Rootletin PF15035.6 ADV22586.1 - 0.016 15.3 13.5 0.051 13.6 3.1 2.3 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion Occludin_ELL PF07303.13 ADV22586.1 - 0.26 12.0 5.3 0.5 11.1 0.3 2.5 2 0 0 2 2 2 0 Occludin homology domain PI3K_P85_iSH2 PF16454.5 ADV22586.1 - 0.29 10.7 13.1 0.41 10.2 2.9 2.2 2 0 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain TMPIT PF07851.13 ADV22586.1 - 1.3 8.2 10.5 1.1 8.4 3.3 2.1 2 0 0 2 2 2 0 TMPIT-like protein DUF1515 PF07439.11 ADV22586.1 - 1.8 8.6 6.9 2.7 8.1 0.1 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1515) Atg14 PF10186.9 ADV22586.1 - 4.6 6.2 20.7 0.16 11.0 4.7 2.3 2 1 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 JIP_LZII PF16471.5 ADV22586.1 - 5.8 7.2 14.6 2.3 8.4 2.3 2.6 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II APS_kinase PF01583.20 ADV22588.1 - 4.8e-69 231.3 0.0 5.8e-69 231.0 0.0 1.1 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_33 PF13671.6 ADV22588.1 - 5.4e-05 23.4 0.0 9e-05 22.7 0.0 1.4 1 1 0 1 1 1 1 AAA domain KTI12 PF08433.10 ADV22588.1 - 0.00084 18.9 0.0 0.0012 18.3 0.0 1.1 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_18 PF13238.6 ADV22588.1 - 0.00098 19.7 0.0 0.0013 19.3 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ADV22588.1 - 0.0038 17.6 0.0 0.005 17.2 0.0 1.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 ADV22588.1 - 0.01 15.6 0.0 0.018 14.8 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain Zeta_toxin PF06414.12 ADV22588.1 - 0.033 13.5 0.0 0.048 12.9 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin DUF463 PF04317.12 ADV22588.1 - 0.042 12.8 0.0 0.062 12.2 0.0 1.2 1 0 0 1 1 1 0 YcjX-like family, DUF463 PRK PF00485.18 ADV22588.1 - 0.075 12.8 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family AAA_14 PF13173.6 ADV22588.1 - 0.14 12.2 0.0 0.29 11.2 0.0 1.6 2 0 0 2 2 2 0 AAA domain G-alpha PF00503.20 ADV22588.1 - 0.24 10.5 0.0 0.34 10.0 0.0 1.1 1 0 0 1 1 1 0 G-protein alpha subunit Endonuclease_NS PF01223.23 ADV22589.1 - 1e-53 182.5 0.0 2.6e-53 181.2 0.0 1.6 1 1 0 1 1 1 1 DNA/RNA non-specific endonuclease BRO1 PF03097.18 ADV22590.1 - 4.5e-13 48.8 0.0 6.4e-13 48.3 0.0 1.1 1 0 0 1 1 1 1 BRO1-like domain T2SSC PF11356.8 ADV22590.1 - 0.1 12.5 0.2 0.38 10.7 0.2 1.9 1 0 0 1 1 1 0 Type II secretion system protein C DUF4407 PF14362.6 ADV22590.1 - 0.26 10.6 0.9 0.38 10.1 0.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Glyco_hydro_cc PF11790.8 ADV22591.1 - 9.8e-71 238.1 2.4 1.1e-70 237.9 2.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core Lactamase_B_2 PF12706.7 ADV22592.1 - 1.5e-06 27.9 0.0 0.0051 16.3 0.0 2.7 2 0 0 2 2 2 2 Beta-lactamase superfamily domain Lactamase_B PF00753.27 ADV22592.1 - 1.2e-05 25.4 0.1 2.4e-05 24.4 0.1 1.6 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_4 PF13691.6 ADV22592.1 - 0.002 17.8 0.0 0.005 16.5 0.0 1.6 1 0 0 1 1 1 1 tRNase Z endonuclease PDEase_II PF02112.15 ADV22592.1 - 0.035 13.2 0.1 0.056 12.5 0.1 1.2 1 0 0 1 1 1 0 cAMP phosphodiesterases class-II Peptidase_C92 PF05708.12 ADV22592.1 - 0.064 13.4 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family ENTH PF01417.20 ADV22593.1 - 5e-50 168.7 0.2 8.9e-50 167.9 0.2 1.4 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.16 ADV22593.1 - 0.00034 19.7 0.0 0.00034 19.7 0.0 2.4 2 0 0 2 2 2 1 ANTH domain UIM PF02809.20 ADV22593.1 - 0.0018 18.1 18.5 0.009 15.9 5.0 3.2 3 0 0 3 3 3 2 Ubiquitin interaction motif LMBR1 PF04791.16 ADV22593.1 - 1.9 7.3 5.7 2.5 6.9 5.7 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein CBFD_NFYB_HMF PF00808.23 ADV22594.1 - 1.5e-26 92.4 0.2 2.2e-26 91.9 0.2 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 ADV22594.1 - 1.7e-05 25.2 1.9 2.5e-05 24.6 0.0 2.0 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 ADV22594.1 - 0.0021 18.2 0.0 0.003 17.6 0.0 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TFIID-18kDa PF02269.16 ADV22594.1 - 0.035 14.1 0.0 0.058 13.4 0.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor IID, 18kD subunit FragX_IP PF05994.11 ADV22594.1 - 0.19 9.8 0.0 0.22 9.6 0.0 1.0 1 0 0 1 1 1 0 Cytoplasmic Fragile-X interacting family zf-Tim10_DDP PF02953.15 ADV22594.1 - 0.32 10.7 2.4 0.88 9.3 0.5 2.2 1 1 1 2 2 2 0 Tim10/DDP family zinc finger Chitin_synth_1 PF01644.17 ADV22595.1 - 6.7e-65 218.0 0.0 1.2e-64 217.2 0.0 1.4 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_2 PF03142.15 ADV22595.1 - 3.2e-19 69.0 0.0 1.4e-14 53.6 0.0 2.3 2 0 0 2 2 2 2 Chitin synthase Chitin_synth_1N PF08407.11 ADV22595.1 - 8.7e-16 57.6 0.1 2.3e-15 56.3 0.0 1.7 2 0 0 2 2 2 1 Chitin synthase N-terminal Scm3 PF10384.9 ADV22596.1 - 2.7e-17 62.2 1.5 2.7e-17 62.2 1.5 1.8 2 0 0 2 2 2 1 Centromere protein Scm3 MHYT PF03707.16 ADV22597.1 - 3.4e-14 52.7 24.4 5.8e-07 29.6 2.6 4.5 4 0 0 4 4 4 3 Bacterial signalling protein N terminal repeat DUF2384 PF09722.10 ADV22597.1 - 0.14 12.2 0.1 0.27 11.3 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2384) DFP PF04127.15 ADV22598.1 - 6.8e-18 65.2 0.0 6.1e-10 39.2 0.0 2.1 2 0 0 2 2 2 2 DNA / pantothenate metabolism flavoprotein FIST PF08495.10 ADV22599.1 - 0.0002 21.4 0.0 0.00031 20.8 0.0 1.3 1 0 0 1 1 1 1 FIST N domain M20_dimer PF07687.14 ADV22600.1 - 4.2e-09 36.3 0.0 1.1e-08 35.0 0.0 1.7 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M20 PF01546.28 ADV22600.1 - 1.7e-06 27.9 0.2 2.8e-06 27.2 0.2 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 HLH PF00010.26 ADV22600.1 - 0.22 11.5 0.1 0.84 9.6 0.0 2.0 2 0 0 2 2 2 0 Helix-loop-helix DNA-binding domain APG12 PF04110.13 ADV22601.1 - 1.6e-31 108.5 0.0 1.9e-31 108.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Atg8 PF02991.16 ADV22601.1 - 0.0018 18.4 0.0 0.002 18.3 0.0 1.1 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like Ufm1 PF03671.14 ADV22601.1 - 0.025 14.7 0.0 0.041 14.0 0.0 1.4 1 1 0 1 1 1 0 Ubiquitin fold modifier 1 protein XFP_N PF09364.10 ADV22602.1 - 2.5e-138 460.9 0.4 3.7e-138 460.3 0.4 1.2 1 0 0 1 1 1 1 XFP N-terminal domain XFP PF03894.15 ADV22602.1 - 7.8e-75 250.4 0.0 1.1e-74 249.9 0.0 1.2 1 0 0 1 1 1 1 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase XFP_C PF09363.10 ADV22602.1 - 6.7e-68 228.1 0.0 1.1e-67 227.5 0.0 1.3 1 0 0 1 1 1 1 XFP C-terminal domain Transketolase_C PF02780.20 ADV22602.1 - 0.00024 21.0 0.4 0.00088 19.2 0.3 2.0 1 1 1 2 2 2 1 Transketolase, C-terminal domain TPP_enzyme_C PF02775.21 ADV22602.1 - 0.028 14.2 0.1 0.064 13.0 0.1 1.5 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain ParA PF10609.9 ADV22603.1 - 1.8e-96 322.4 0.0 2.1e-96 322.2 0.0 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 ADV22603.1 - 2.2e-07 31.0 0.0 7.3e-07 29.3 0.0 2.0 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 ADV22603.1 - 0.00022 21.2 0.1 0.0031 17.5 0.1 2.1 1 1 0 1 1 1 1 AAA domain ArsA_ATPase PF02374.15 ADV22603.1 - 0.00023 20.5 1.3 0.0025 17.0 0.2 2.3 2 1 0 2 2 2 1 Anion-transporting ATPase CBP_BcsQ PF06564.12 ADV22603.1 - 0.0017 17.9 0.0 0.0049 16.4 0.0 1.7 1 1 0 1 1 1 1 Cellulose biosynthesis protein BcsQ Fer4_NifH PF00142.18 ADV22603.1 - 0.0018 17.7 0.0 0.2 11.0 0.0 2.6 2 1 1 3 3 3 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_26 PF13500.6 ADV22603.1 - 0.0023 17.8 0.0 0.1 12.4 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 ADV22603.1 - 0.031 13.8 0.0 0.055 13.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 ADV22603.1 - 0.049 13.5 0.0 0.1 12.5 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase PI3_PI4_kinase PF00454.27 ADV22604.1 - 1.7e-48 165.7 0.0 9.9e-48 163.1 0.0 2.2 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase UME PF08064.13 ADV22604.1 - 1.2e-27 95.8 0.0 1.1e-26 92.7 0.0 2.8 2 0 0 2 2 2 1 UME (NUC010) domain FAT PF02259.23 ADV22604.1 - 4.7e-14 52.4 0.0 1.4e-13 50.8 0.0 1.9 2 0 0 2 2 2 1 FAT domain FATC PF02260.20 ADV22604.1 - 2.9e-09 36.6 0.1 7.7e-09 35.2 0.1 1.8 1 0 0 1 1 1 1 FATC domain DUF3385 PF11865.8 ADV22604.1 - 0.00046 20.1 0.1 0.005 16.8 0.0 2.8 2 0 0 2 2 2 1 Domain of unknown function (DUF3385) Arm_3 PF16186.5 ADV22604.1 - 0.11 12.1 0.0 0.25 10.9 0.0 1.6 1 0 0 1 1 1 0 Atypical Arm repeat SLX9 PF15341.6 ADV22604.1 - 0.95 9.9 9.4 0.27 11.6 0.1 3.7 4 0 0 4 4 4 0 Ribosome biogenesis protein SLX9 Methyltransf_16 PF10294.9 ADV22605.1 - 2.2e-20 73.1 0.0 3e-20 72.7 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase ZZ PF00569.17 ADV22606.1 - 5e-27 93.5 31.4 1.9e-09 37.2 4.5 3.4 3 0 0 3 3 3 3 Zinc finger, ZZ type N_BRCA1_IG PF16158.5 ADV22606.1 - 1.1e-13 51.8 0.1 2.6e-13 50.6 0.1 1.7 1 0 0 1 1 1 1 Ig-like domain from next to BRCA1 gene C1_2 PF03107.16 ADV22606.1 - 1.1e-09 38.4 30.0 0.00016 21.9 5.4 3.7 3 0 0 3 3 3 3 C1 domain PHM7_cyt PF14703.6 ADV22606.1 - 0.2 11.9 1.0 2.7 8.2 0.1 2.3 2 0 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter Fcf1 PF04900.12 ADV22607.1 - 2.7e-38 130.4 1.8 4.2e-38 129.7 1.8 1.3 1 0 0 1 1 1 1 Fcf1 PIN_9 PF18477.1 ADV22607.1 - 1.4e-10 41.5 0.9 2.2e-10 40.8 0.0 1.7 2 0 0 2 2 2 1 PIN like domain Voltage_CLC PF00654.20 ADV22608.1 - 9.7e-94 314.5 24.7 9.7e-94 314.5 24.7 2.1 2 1 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 ADV22608.1 - 0.016 15.6 0.0 0.12 12.8 0.0 2.4 2 0 0 2 2 2 0 CBS domain NMN_transporter PF04973.12 ADV22609.1 - 0.019 15.0 0.1 0.04 13.9 0.1 1.5 1 0 0 1 1 1 0 Nicotinamide mononucleotide transporter WD40 PF00400.32 ADV22610.1 - 4.2e-64 211.0 14.0 1.6e-10 41.3 0.1 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat Tup_N PF08581.10 ADV22610.1 - 6.4e-31 106.5 5.0 1.1e-30 105.8 5.0 1.4 1 0 0 1 1 1 1 Tup N-terminal ANAPC4_WD40 PF12894.7 ADV22610.1 - 7.6e-27 93.5 0.3 5.8e-05 23.3 0.0 6.3 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ADV22610.1 - 1.1e-12 48.0 0.0 0.011 15.1 0.0 5.4 6 0 0 6 6 6 3 WD40-like domain Ge1_WD40 PF16529.5 ADV22610.1 - 1e-10 41.1 0.0 0.055 12.4 0.0 5.1 1 1 4 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ADV22610.1 - 1.7e-07 30.3 0.2 0.025 13.2 0.0 3.9 2 2 1 4 4 4 2 Nucleoporin Nup120/160 PD40 PF07676.12 ADV22610.1 - 1.3e-06 28.2 0.0 19 5.4 0.0 5.7 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat eIF2A PF08662.11 ADV22610.1 - 1.5e-05 25.0 0.0 0.38 10.6 0.0 3.7 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nbas_N PF15492.6 ADV22610.1 - 5.1e-05 22.7 0.1 1.1 8.5 0.0 3.8 3 1 1 4 4 4 2 Neuroblastoma-amplified sequence, N terminal Cytochrom_D1 PF02239.16 ADV22610.1 - 9.2e-05 21.1 0.1 0.16 10.5 0.0 3.2 1 1 0 2 2 2 2 Cytochrome D1 heme domain Golgin_A5 PF09787.9 ADV22610.1 - 0.001 18.6 0.3 0.0016 18.0 0.3 1.2 1 0 0 1 1 1 1 Golgin subfamily A member 5 Gmad1 PF10647.9 ADV22610.1 - 0.0027 17.5 0.1 0.41 10.3 0.1 3.1 2 1 1 3 3 3 1 Lipoprotein LpqB beta-propeller domain DUF5122 PF17164.4 ADV22610.1 - 0.0033 17.7 0.9 9.1 6.7 0.0 5.2 6 0 0 6 6 6 0 Domain of unknown function (DUF5122) beta-propeller Nucleoporin_N PF08801.11 ADV22610.1 - 0.0041 15.9 0.4 0.52 9.0 0.2 3.1 2 1 1 3 3 3 1 Nup133 N terminal like nos_propeller PF18764.1 ADV22610.1 - 0.0095 15.8 0.0 7.4 6.6 0.0 3.9 5 0 0 5 5 4 1 Nitrous oxide reductase propeller repeat TPX2 PF06886.11 ADV22610.1 - 0.022 15.0 2.8 0.041 14.1 2.8 1.4 1 0 0 1 1 1 0 Targeting protein for Xklp2 (TPX2) DUF4402 PF14352.6 ADV22610.1 - 0.041 14.5 0.0 4.7 7.9 0.0 2.6 3 0 0 3 3 2 0 Domain of unknown function (DUF4402) SHE3 PF17078.5 ADV22610.1 - 0.16 11.6 1.4 0.27 10.9 1.4 1.2 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 DUF5570 PF17731.1 ADV22610.1 - 0.26 11.4 3.7 2.9 8.0 0.0 3.8 5 0 0 5 5 4 0 Family of unknown function (DUF5570) Proteasome_A_N PF10584.9 ADV22610.1 - 7.7 6.3 7.5 83 3.0 0.0 4.5 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature DUF1674 PF07896.12 ADV22612.1 - 3.7e-14 52.9 3.5 6.8e-14 52.1 3.5 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1674) peroxidase PF00141.23 ADV22613.1 - 3e-47 161.3 0.0 4.5e-47 160.7 0.0 1.3 1 0 0 1 1 1 1 Peroxidase Fasciclin PF02469.22 ADV22614.1 - 8.4e-21 74.5 0.0 7.4e-15 55.3 0.0 2.2 2 0 0 2 2 2 2 Fasciclin domain Ribosomal_L1 PF00687.21 ADV22615.1 - 1.5e-46 158.7 1.3 1.8e-46 158.5 1.3 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Arrestin_N PF00339.29 ADV22616.1 - 0.29 11.2 0.6 2 8.5 0.0 2.5 2 1 0 2 2 2 0 Arrestin (or S-antigen), N-terminal domain HOOK PF05622.12 ADV22617.1 - 2.7e-49 168.0 55.4 2.3e-48 164.9 29.1 2.9 1 1 0 2 2 2 2 HOOK protein DHR10 PF18595.1 ADV22617.1 - 0.008 16.2 17.3 0.008 16.2 17.3 7.3 3 2 4 7 7 7 2 Designed helical repeat protein 10 domain TolA_bind_tri PF16331.5 ADV22617.1 - 2.3 8.3 58.9 0.071 13.2 11.7 8.1 6 3 2 8 8 8 0 TolA binding protein trimerisation KASH_CCD PF14662.6 ADV22617.1 - 2.3 8.0 98.0 0.5 10.2 35.5 6.2 4 1 2 6 6 6 0 Coiled-coil region of CCDC155 or KASH DUF4407 PF14362.6 ADV22617.1 - 5 6.4 58.8 0.79 9.0 10.3 4.6 1 1 2 4 4 4 0 Domain of unknown function (DUF4407) BLOC1_2 PF10046.9 ADV22617.1 - 7.3 7.0 46.5 0.5 10.7 4.8 7.0 5 1 2 7 7 7 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 FlxA PF14282.6 ADV22617.1 - 7.8 6.5 62.4 1.4 8.9 1.9 8.0 4 2 3 7 7 7 0 FlxA-like protein Ribosomal_S6 PF01250.17 ADV22618.1 - 5.2e-13 49.1 0.0 7.2e-13 48.6 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S6 Sec20 PF03908.13 ADV22619.1 - 3e-19 68.7 4.3 3e-19 68.7 4.3 1.9 2 0 0 2 2 2 1 Sec20 Glucosamine_iso PF01182.20 ADV22620.1 - 5.5e-70 235.8 0.0 7.7e-70 235.3 0.0 1.2 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Fe-S_biosyn PF01521.20 ADV22621.1 - 1.4e-18 67.1 0.0 1.9e-18 66.7 0.0 1.2 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis STAC2_u1 PF16664.5 ADV22621.1 - 0.031 14.7 0.6 0.046 14.2 0.6 1.2 1 0 0 1 1 1 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 Cyclin_N PF00134.23 ADV22622.1 - 7.1e-09 35.5 0.0 4.8e-08 32.8 0.0 2.0 1 1 0 1 1 1 1 Cyclin, N-terminal domain DUF5455 PF17537.2 ADV22622.1 - 0.073 13.5 0.1 0.14 12.6 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5455) DUF1748 PF08520.10 ADV22623.1 - 8.9e-23 80.0 0.0 9.8e-23 79.9 0.0 1.0 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1748) Formyl_trans_N PF00551.19 ADV22624.1 - 8.3e-22 77.8 0.0 1.2e-21 77.3 0.0 1.3 1 0 0 1 1 1 1 Formyl transferase Formyl_trans_C PF02911.18 ADV22624.1 - 2.9e-18 66.0 0.0 6.8e-18 64.8 0.0 1.7 1 0 0 1 1 1 1 Formyl transferase, C-terminal domain DAPG_hydrolase PF18089.1 ADV22625.1 - 0.024 14.2 0.2 0.047 13.2 0.2 1.4 1 0 0 1 1 1 0 DAPG hydrolase PhiG domain Strep_pep PF14404.6 ADV22625.1 - 0.11 12.8 0.0 0.8 10.0 0.0 2.2 2 0 0 2 2 2 0 Ribosomally synthesized peptide in Streptomyces species Hydrolase_like PF13242.6 ADV22626.1 - 4.6e-24 84.3 0.1 2.4e-23 82.0 0.0 2.0 2 0 0 2 2 2 1 HAD-hyrolase-like Hydrolase_6 PF13344.6 ADV22626.1 - 2.9e-23 81.9 0.0 4.8e-23 81.2 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ADV22626.1 - 0.027 14.7 0.0 8.7 6.6 0.0 2.4 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase HMG_box PF00505.19 ADV22628.1 - 2.5e-18 66.2 0.4 2.5e-18 66.2 0.4 2.0 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ADV22628.1 - 2.3e-12 47.3 0.2 2.3e-12 47.3 0.2 2.1 2 0 0 2 2 2 1 HMG-box domain CHDNT PF08073.12 ADV22628.1 - 0.00021 21.2 0.0 0.0004 20.3 0.0 1.3 1 0 0 1 1 1 1 CHDNT (NUC034) domain YABBY PF04690.13 ADV22628.1 - 0.00063 20.4 0.8 0.0014 19.2 0.0 1.9 2 0 0 2 2 2 1 YABBY protein Ccdc124 PF06244.12 ADV22628.1 - 0.12 12.9 0.0 0.12 12.9 0.0 2.7 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 124 /Oxs1 Med19 PF10278.9 ADV22628.1 - 0.22 11.4 13.9 0.094 12.6 7.5 2.3 2 0 0 2 2 2 0 Mediator of RNA pol II transcription subunit 19 RNA_polI_A34 PF08208.11 ADV22628.1 - 4.1 7.5 21.3 1.9 8.6 15.8 2.1 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 SUR7 PF06687.12 ADV22629.1 - 1.5e-23 83.6 14.4 2.1e-23 83.1 14.4 1.2 1 0 0 1 1 1 1 SUR7/PalI family Trp_oprn_chp PF09534.10 ADV22629.1 - 0.00035 20.4 0.9 0.0005 19.9 0.0 1.6 2 0 0 2 2 2 1 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Arteri_Gl PF00951.18 ADV22629.1 - 0.37 10.6 3.5 0.64 9.8 3.5 1.3 1 0 0 1 1 1 0 Arterivirus GL envelope glycoprotein Clat_adaptor_s PF01217.20 ADV22630.1 - 8.3e-56 187.9 2.4 9.5e-56 187.7 2.4 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Clp1 PF06807.14 ADV22631.1 - 5.1e-25 88.2 0.0 1.1e-11 45.1 0.0 2.5 2 0 0 2 2 2 2 Pre-mRNA cleavage complex II protein Clp1 CLP1_P PF16575.5 ADV22631.1 - 7.2e-21 74.8 0.0 2.1e-20 73.3 0.0 1.8 1 1 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop CLP1_N PF16573.5 ADV22631.1 - 4.8e-17 62.0 0.0 9.3e-17 61.0 0.0 1.5 1 0 0 1 1 1 1 N-terminal beta-sandwich domain of polyadenylation factor AAA_28 PF13521.6 ADV22631.1 - 0.0051 17.1 0.1 0.053 13.8 0.1 2.3 2 0 0 2 2 2 1 AAA domain ATPase_2 PF01637.18 ADV22631.1 - 0.074 13.0 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_16 PF13191.6 ADV22631.1 - 0.075 13.4 0.0 0.17 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_24 PF13479.6 ADV22631.1 - 0.081 12.6 0.1 0.17 11.6 0.1 1.5 1 0 0 1 1 1 0 AAA domain Arf PF00025.21 ADV22631.1 - 0.11 11.9 0.0 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 ADP-ribosylation factor family Dynamin_N PF00350.23 ADV22631.1 - 0.14 12.2 0.2 0.36 10.9 0.1 1.7 2 0 0 2 2 2 0 Dynamin family AAA_18 PF13238.6 ADV22631.1 - 0.14 12.7 0.6 0.54 10.8 0.2 2.0 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.9 ADV22631.1 - 0.15 11.8 0.1 0.35 10.6 0.1 1.6 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_7 PF12775.7 ADV22631.1 - 0.2 11.1 0.1 0.4 10.2 0.1 1.4 1 1 0 1 1 1 0 P-loop containing dynein motor region SRPRB PF09439.10 ADV22631.1 - 0.21 11.0 0.0 0.49 9.8 0.0 1.6 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Exo_endo_phos PF03372.23 ADV22632.1 - 1.3e-10 41.2 0.0 2.6e-10 40.2 0.0 1.6 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RabGAP-TBC PF00566.18 ADV22633.1 - 1.1e-48 165.7 0.0 1.5e-48 165.3 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Vps62 PF06101.11 ADV22634.1 - 5.8e-09 34.8 0.6 4.7e-06 25.2 0.1 2.3 2 0 0 2 2 2 2 Vacuolar protein sorting-associated protein 62 DNA_binding_1 PF01035.20 ADV22635.1 - 1.9e-23 82.4 0.0 2.3e-23 82.1 0.0 1.1 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain DUF1729 PF08354.10 ADV22637.1 - 3.4e-152 506.4 0.0 7.4e-152 505.3 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF1729) Acyl_transf_1 PF00698.21 ADV22637.1 - 2.3e-69 234.4 0.0 1.1e-68 232.1 0.0 2.3 1 0 0 1 1 1 1 Acyl transferase domain Fas_alpha_ACP PF18325.1 ADV22637.1 - 7e-67 224.8 0.0 1.6e-66 223.7 0.0 1.7 1 0 0 1 1 1 1 Fatty acid synthase subunit alpha Acyl carrier domain FAS_meander PF17951.1 ADV22637.1 - 2.2e-46 157.3 0.0 5.3e-46 156.1 0.0 1.7 1 0 0 1 1 1 1 Fatty acid synthase meander beta sheet domain FAS_I_H PF18314.1 ADV22637.1 - 9e-32 110.4 0.1 2.8e-31 108.7 0.1 1.8 1 0 0 1 1 1 1 Fatty acid synthase type I helical domain MaoC_dehydratas PF01575.19 ADV22637.1 - 1.1e-29 102.4 0.3 5.6e-29 100.2 0.0 2.2 2 0 0 2 2 2 1 MaoC like domain SAT PF16073.5 ADV22637.1 - 1.2e-29 103.7 0.0 3e-29 102.4 0.0 1.7 2 0 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis FAS_N PF17828.1 ADV22637.1 - 1.3e-15 57.5 0.7 2.8e-14 53.2 0.1 2.4 2 0 0 2 2 2 1 N-terminal domain in fatty acid synthase subunit beta MaoC_dehydrat_N PF13452.6 ADV22637.1 - 2.8e-13 50.2 0.1 2.2e-12 47.2 0.0 2.5 3 0 0 3 3 3 1 N-terminal half of MaoC dehydratase UBX PF00789.20 ADV22638.1 - 0.00028 21.0 0.0 0.0023 18.1 0.0 2.3 2 0 0 2 2 2 1 UBX domain Hemerythrin PF01814.23 ADV22639.1 - 3.5e-09 37.4 1.1 4.9e-09 36.9 1.1 1.2 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain P34-Arc PF04045.14 ADV22640.1 - 3.7e-104 347.7 0.0 4.4e-104 347.4 0.0 1.0 1 0 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc Cyclin_N PF00134.23 ADV22641.1 - 8e-44 148.5 2.0 3.9e-42 143.0 0.8 2.4 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.19 ADV22641.1 - 2.5e-26 92.1 0.0 5e-26 91.1 0.0 1.5 1 0 0 1 1 1 1 Cyclin, C-terminal domain Pex16 PF08610.10 ADV22642.1 - 6.7e-88 295.0 0.0 7.6e-88 294.8 0.0 1.0 1 0 0 1 1 1 1 Peroxisomal membrane protein (Pex16) FAS_I_H PF18314.1 ADV22643.1 - 1.1e-31 110.1 0.2 1.3e-30 106.5 0.0 2.2 2 0 0 2 2 2 1 Fatty acid synthase type I helical domain ketoacyl-synt PF00109.26 ADV22643.1 - 1.6e-24 86.9 0.3 2.6e-24 86.2 0.3 1.3 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 ADV22643.1 - 3.6e-15 56.0 0.0 1.1e-14 54.4 0.0 1.9 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain ACPS PF01648.20 ADV22643.1 - 4.9e-13 49.2 0.0 1.1e-12 48.1 0.0 1.6 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily Thiolase_N PF00108.23 ADV22643.1 - 0.016 14.6 0.1 0.048 13.0 0.1 1.8 1 0 0 1 1 1 0 Thiolase, N-terminal domain KR PF08659.10 ADV22643.1 - 0.016 15.1 0.0 0.051 13.5 0.0 1.8 1 0 0 1 1 1 0 KR domain DUF1764 PF08576.10 ADV22644.1 - 1.4e-21 77.2 15.7 4.7e-20 72.4 6.8 2.3 1 1 1 2 2 2 2 Eukaryotic protein of unknown function (DUF1764) Menin PF05053.13 ADV22644.1 - 2.7 6.2 5.6 3.4 5.9 5.6 1.1 1 0 0 1 1 1 0 Menin Corona_S2 PF01601.16 ADV22645.1 - 0.33 9.4 0.9 0.54 8.7 0.9 1.2 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein DivIVA PF05103.13 ADV22645.1 - 1.6 8.9 31.3 2.7 8.1 9.2 4.0 2 1 1 3 3 3 0 DivIVA protein Lzipper-MIP1 PF14389.6 ADV22645.1 - 6.5 7.1 30.7 0.51 10.7 0.3 4.5 4 0 0 4 4 4 0 Leucine-zipper of ternary complex factor MIP1 DUF1515 PF07439.11 ADV22645.1 - 6.7 6.8 17.4 2.2 8.3 5.8 3.9 3 1 0 3 3 3 0 Protein of unknown function (DUF1515) CRAL_TRIO PF00650.20 ADV22646.1 - 3.2e-14 53.0 0.0 4.3e-14 52.5 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain BPD_transp_1 PF00528.22 ADV22646.1 - 0.037 13.8 0.6 0.048 13.4 0.0 1.4 2 0 0 2 2 2 0 Binding-protein-dependent transport system inner membrane component Arm_vescicular PF18770.1 ADV22646.1 - 0.061 13.3 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Armadillo tether-repeat of vescicular transport factor CRAL_TRIO_2 PF13716.6 ADV22646.1 - 0.17 12.1 0.0 0.26 11.4 0.0 1.3 1 0 0 1 1 1 0 Divergent CRAL/TRIO domain CHCH PF06747.13 ADV22647.1 - 3.6e-08 33.3 2.5 6.1e-08 32.6 2.5 1.4 1 0 0 1 1 1 1 CHCH domain GCK PF07802.11 ADV22647.1 - 0.0028 18.0 1.1 0.0087 16.5 1.1 1.8 1 0 0 1 1 1 1 GCK domain NARP1 PF12569.8 ADV22649.1 - 1.3e-172 575.3 1.6 1.3e-172 575.3 1.6 2.5 4 0 0 4 4 3 1 NMDA receptor-regulated protein 1 TPR_14 PF13428.6 ADV22649.1 - 1.4e-11 44.1 35.2 0.00011 22.7 0.0 11.5 10 4 4 14 14 11 3 Tetratricopeptide repeat TPR_2 PF07719.17 ADV22649.1 - 3.5e-10 39.2 24.3 0.013 15.6 0.0 10.1 10 0 0 10 10 9 3 Tetratricopeptide repeat TPR_19 PF14559.6 ADV22649.1 - 1e-09 38.8 26.5 3.6e-06 27.4 0.5 8.1 6 2 2 9 9 8 3 Tetratricopeptide repeat TPR_11 PF13414.6 ADV22649.1 - 2.7e-09 36.6 12.6 0.0014 18.3 0.5 7.2 7 0 0 7 7 7 3 TPR repeat TPR_6 PF13174.6 ADV22649.1 - 3.5e-09 36.7 9.1 0.013 16.1 0.0 7.9 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_1 PF00515.28 ADV22649.1 - 3.6e-06 26.6 8.2 0.2 11.5 0.1 7.0 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_16 PF13432.6 ADV22649.1 - 3.7e-06 27.5 23.0 0.058 14.0 0.1 9.5 9 2 2 11 11 11 2 Tetratricopeptide repeat TPR_7 PF13176.6 ADV22649.1 - 6.9e-05 22.6 2.3 15 5.9 0.1 6.0 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_21 PF09976.9 ADV22649.1 - 0.00013 21.7 0.3 0.00013 21.7 0.3 3.9 5 1 1 6 6 5 1 Tetratricopeptide repeat-like domain TPR_12 PF13424.6 ADV22649.1 - 0.00023 21.4 18.2 0.21 11.9 1.7 6.8 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_9 PF13371.6 ADV22649.1 - 0.0031 17.6 11.5 0.93 9.7 0.2 5.7 6 0 0 6 6 6 2 Tetratricopeptide repeat RPN7 PF10602.9 ADV22649.1 - 0.0065 16.2 1.3 2.6 7.7 0.0 3.9 4 1 1 5 5 5 1 26S proteasome subunit RPN7 QLQ PF08880.11 ADV22649.1 - 0.035 13.9 0.0 0.11 12.2 0.0 1.9 1 0 0 1 1 1 0 QLQ TPR_8 PF13181.6 ADV22649.1 - 0.054 13.7 0.0 0.054 13.7 0.0 6.1 7 0 0 7 7 5 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ADV22649.1 - 0.22 11.6 2.0 5.9 7.1 0.0 3.5 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_17 PF13431.6 ADV22649.1 - 9.5 6.9 16.6 6.4 7.4 0.0 6.8 10 0 0 10 10 8 0 Tetratricopeptide repeat UQ_con PF00179.26 ADV22650.1 - 7.2e-12 45.1 0.2 8.7e-12 44.9 0.2 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Arf PF00025.21 ADV22651.1 - 7.3e-41 139.5 0.0 8.6e-41 139.3 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 ADV22651.1 - 6.7e-18 64.8 0.0 7.7e-18 64.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ADV22651.1 - 2.2e-15 56.9 0.0 3.1e-15 56.4 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 ADV22651.1 - 1.7e-09 37.4 0.0 1.9e-09 37.2 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 ADV22651.1 - 1.3e-07 31.3 0.0 1.5e-07 31.0 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ADV22651.1 - 5.3e-07 29.7 0.0 8.3e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ADV22651.1 - 0.00047 19.7 0.0 0.0061 16.1 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain G-alpha PF00503.20 ADV22651.1 - 0.00074 18.8 0.2 0.0045 16.2 0.0 2.0 1 1 1 2 2 2 1 G-protein alpha subunit Dynamin_N PF00350.23 ADV22651.1 - 0.0095 16.0 0.2 1.6 8.8 0.2 2.2 1 1 0 2 2 2 1 Dynamin family AAA_7 PF12775.7 ADV22651.1 - 0.016 14.7 0.0 0.025 14.1 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region ATP_bind_1 PF03029.17 ADV22651.1 - 0.036 13.8 0.0 1.1 9.0 0.0 2.0 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein GFO_IDH_MocA PF01408.22 ADV22652.1 - 2.5e-14 54.1 0.0 4e-14 53.5 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Gal11_ABD1 PF18535.1 ADV22653.1 - 0.044 13.9 0.0 0.11 12.5 0.0 1.7 1 0 0 1 1 1 0 Gal11 activator-binding domain (ABD1) MarR_2 PF12802.7 ADV22653.1 - 0.18 11.7 0.3 0.94 9.4 0.0 2.3 3 0 0 3 3 3 0 MarR family ATP_bind_3 PF01171.20 ADV22654.1 - 2.5e-17 63.2 0.0 3.6e-17 62.7 0.0 1.2 1 0 0 1 1 1 1 PP-loop family zn-ribbon_14 PF16503.5 ADV22654.1 - 6.7e-14 51.1 4.8 6.7e-14 51.1 4.8 3.4 4 0 0 4 4 4 1 Zinc-ribbon RecR PF02132.15 ADV22654.1 - 0.00077 19.0 0.7 0.00077 19.0 0.7 3.0 4 0 0 4 4 4 1 RecR protein DNA_pol_B_palm PF14792.6 ADV22654.1 - 0.084 13.1 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 DNA polymerase beta palm zf-RING_2 PF13639.6 ADV22655.1 - 8.2e-12 45.3 4.7 1.8e-11 44.1 4.7 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 ADV22655.1 - 2.8e-08 33.4 1.0 5.8e-08 32.3 1.0 1.6 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 ADV22655.1 - 4.7e-06 26.3 4.3 8.7e-06 25.5 4.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ADV22655.1 - 3.1e-05 24.2 4.7 0.00012 22.3 4.7 1.9 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 ADV22655.1 - 5e-05 23.3 1.1 9.3e-05 22.4 1.1 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4 PF00097.25 ADV22655.1 - 0.00012 21.9 2.1 0.00023 21.0 2.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ADV22655.1 - 0.00024 20.9 4.4 0.004 17.0 5.0 2.3 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 ADV22655.1 - 0.0012 18.6 2.8 0.002 17.9 2.8 1.4 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-RING_5 PF14634.6 ADV22655.1 - 0.0022 17.9 1.3 0.0042 17.0 1.3 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 ADV22655.1 - 0.005 16.7 0.9 0.0094 15.8 0.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ADV22655.1 - 0.012 15.6 5.8 0.057 13.5 0.9 2.5 2 0 0 2 2 2 0 RING-type zinc-finger FANCL_C PF11793.8 ADV22655.1 - 0.025 14.8 1.7 0.07 13.3 1.7 1.8 1 1 0 1 1 1 0 FANCL C-terminal domain Rad50_zn_hook PF04423.14 ADV22655.1 - 0.029 14.2 1.2 4.2 7.3 0.2 2.4 2 0 0 2 2 2 0 Rad50 zinc hook motif Prok-RING_1 PF14446.6 ADV22655.1 - 0.05 13.5 3.7 0.31 11.0 0.8 2.4 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 ABC2_membrane_3 PF12698.7 ADV22655.1 - 0.059 12.5 1.1 0.089 11.9 1.1 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein zf-C2H2_4 PF13894.6 ADV22655.1 - 0.098 13.5 1.0 5.1 8.2 0.3 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger UBZ_FAAP20 PF15750.5 ADV22655.1 - 0.1 12.6 3.5 9.4 6.3 0.7 2.6 2 0 0 2 2 2 0 Ubiquitin-binding zinc-finger TMEM154 PF15102.6 ADV22655.1 - 0.11 12.3 0.8 0.6 10.0 0.0 2.4 2 0 0 2 2 2 0 TMEM154 protein family Vps39_2 PF10367.9 ADV22655.1 - 0.2 12.1 0.8 4.8 7.7 0.3 2.4 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 2 RINGv PF12906.7 ADV22655.1 - 0.39 10.9 2.0 0.85 9.8 2.0 1.6 1 0 0 1 1 1 0 RING-variant domain Zn-C2H2_12 PF18112.1 ADV22655.1 - 0.85 10.1 3.5 12 6.4 0.6 2.6 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain DUF202 PF02656.15 ADV22656.1 - 5 7.6 9.5 42 4.7 4.6 3.4 2 1 0 2 2 2 0 Domain of unknown function (DUF202) eIF3_subunit PF08597.10 ADV22657.1 - 1.2e-51 176.0 25.6 1.3e-51 175.9 25.6 1.0 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit PrlF_antitoxin PF15937.5 ADV22657.1 - 0.043 14.2 0.6 8.7 6.9 0.0 2.4 1 1 1 2 2 2 0 prlF antitoxin for toxin YhaV_toxin DUF3861 PF12977.7 ADV22657.1 - 0.1 12.8 0.2 2.3 8.5 0.2 2.4 1 1 1 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3861) DUF4449 PF14613.6 ADV22658.1 - 1.2e-36 126.3 2.4 1.2e-36 126.3 2.4 3.0 2 1 1 3 3 3 1 Protein of unknown function (DUF4449) DUF4950 PF16308.5 ADV22658.1 - 0.012 15.6 0.0 0.03 14.3 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4950) UPF0565 PF10561.9 ADV22658.1 - 2.1 7.4 7.2 0.12 11.6 0.3 2.1 2 0 0 2 2 2 0 Uncharacterised protein family UPF0565 RRM_1 PF00076.22 ADV22659.1 - 1.1e-34 118.1 0.7 8.3e-16 57.6 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM39linker PF15519.6 ADV22659.1 - 3.2e-09 37.7 0.7 2e-08 35.2 0.7 2.3 1 1 0 1 1 1 1 linker between RRM2 and RRM3 domains in RBM39 protein RRM_occluded PF16842.5 ADV22659.1 - 1e-05 25.3 0.0 0.12 12.3 0.0 2.5 2 0 0 2 2 2 2 Occluded RNA-recognition motif RRM_5 PF13893.6 ADV22659.1 - 4.4e-05 23.1 0.0 0.095 12.3 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 ADV22659.1 - 0.0032 17.4 0.0 0.09 12.8 0.0 2.5 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 ADV22659.1 - 0.025 14.6 0.0 0.025 14.6 0.0 2.5 3 0 0 3 3 3 0 RNA binding motif LRR_4 PF12799.7 ADV22660.1 - 2.8 8.5 5.2 1.2e+02 3.3 0.1 4.6 5 0 0 5 5 5 0 Leucine Rich repeats (2 copies) SWIRM PF04433.17 ADV22661.1 - 2.1e-30 104.9 0.0 7.7e-30 103.1 0.0 2.0 2 0 0 2 2 2 1 SWIRM domain SWIRM-assoc_1 PF16495.5 ADV22661.1 - 5.1e-25 87.2 12.3 9.6e-25 86.4 12.3 1.5 1 0 0 1 1 1 1 SWIRM-associated region 1 Myb_DNA-binding PF00249.31 ADV22661.1 - 1.4e-11 44.4 0.0 3.1e-11 43.3 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ADV22661.1 - 2.8e-06 27.5 0.0 6.1e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain ZZ PF00569.17 ADV22661.1 - 3.1e-06 26.9 2.8 5.3e-06 26.1 2.8 1.3 1 0 0 1 1 1 1 Zinc finger, ZZ type Trypan_PARP PF05887.11 ADV22661.1 - 0.0076 16.2 11.9 0.0076 16.2 11.9 2.5 2 0 0 2 2 2 1 Procyclic acidic repetitive protein (PARP) Calpain_III PF01067.22 ADV22661.1 - 0.0078 16.5 0.1 1.1 9.5 0.0 2.6 2 0 0 2 2 2 1 Calpain large subunit, domain III SANT_DAMP1_like PF16282.5 ADV22661.1 - 0.045 14.0 0.0 0.092 13.0 0.0 1.4 1 0 0 1 1 1 0 SANT/Myb-like domain of DAMP1 NYAP_C PF15452.6 ADV22661.1 - 0.049 13.5 3.1 0.12 12.2 3.1 1.6 1 0 0 1 1 1 0 Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter Zn-ribbon_8 PF09723.10 ADV22661.1 - 0.91 9.7 4.3 2 8.6 4.3 1.5 1 0 0 1 1 1 0 Zinc ribbon domain AAA_12 PF13087.6 ADV22662.1 - 2.5e-50 170.9 0.0 4.4e-50 170.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain Dna2 PF08696.11 ADV22662.1 - 3.4e-47 160.9 0.0 6.3e-47 160.0 0.0 1.4 1 0 0 1 1 1 1 DNA replication factor Dna2 AAA_11 PF13086.6 ADV22662.1 - 7e-32 111.2 0.1 2.6e-15 56.9 0.0 2.4 1 1 1 2 2 2 2 AAA domain AAA_30 PF13604.6 ADV22662.1 - 2.5e-16 60.0 0.0 5.6e-16 58.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 ADV22662.1 - 1.9e-11 44.5 0.0 6.6e-11 42.7 0.0 2.0 2 0 0 2 2 1 1 AAA domain Viral_helicase1 PF01443.18 ADV22662.1 - 3.2e-07 30.3 0.4 0.31 10.7 0.0 4.0 4 0 0 4 4 4 2 Viral (Superfamily 1) RNA helicase Cas_Cas4 PF01930.17 ADV22662.1 - 8e-06 26.0 1.8 1.5e-05 25.1 0.1 2.2 2 0 0 2 2 2 1 Domain of unknown function DUF83 Helicase_RecD PF05127.14 ADV22662.1 - 4.8e-05 23.3 0.0 0.0002 21.2 0.0 2.1 2 0 0 2 2 1 1 Helicase UvrD-helicase PF00580.21 ADV22662.1 - 0.00038 20.1 0.1 0.00086 18.9 0.1 1.6 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain AAA_16 PF13191.6 ADV22662.1 - 0.0021 18.5 0.1 0.0097 16.3 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain SRP54 PF00448.22 ADV22662.1 - 0.0023 17.6 0.1 0.0043 16.7 0.1 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain PIF1 PF05970.14 ADV22662.1 - 0.0036 16.5 0.0 0.13 11.4 0.1 2.2 2 0 0 2 2 2 1 PIF1-like helicase AAA PF00004.29 ADV22662.1 - 0.0065 16.9 0.0 0.11 12.9 0.0 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) MeaB PF03308.16 ADV22662.1 - 0.044 12.8 0.0 0.1 11.6 0.0 1.5 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ResIII PF04851.15 ADV22662.1 - 0.046 13.7 0.4 0.13 12.2 0.1 1.9 2 0 0 2 2 1 0 Type III restriction enzyme, res subunit CbiA PF01656.23 ADV22662.1 - 0.049 13.7 0.5 0.15 12.2 0.5 1.7 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain PrkA PF06798.12 ADV22662.1 - 0.051 13.2 0.3 0.1 12.2 0.3 1.4 1 0 0 1 1 1 0 PrkA serine protein kinase C-terminal domain AAA_7 PF12775.7 ADV22662.1 - 0.054 13.0 0.0 0.13 11.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_33 PF13671.6 ADV22662.1 - 0.062 13.5 0.0 1 9.5 0.0 2.6 2 0 0 2 2 2 0 AAA domain MobB PF03205.14 ADV22662.1 - 0.073 13.0 0.1 0.19 11.6 0.1 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B RuvB_N PF05496.12 ADV22662.1 - 0.073 12.8 0.1 0.17 11.6 0.1 1.6 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain TrwB_AAD_bind PF10412.9 ADV22662.1 - 0.083 11.8 0.1 0.14 11.1 0.1 1.2 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain AAA_5 PF07728.14 ADV22662.1 - 0.089 12.8 0.3 0.52 10.3 0.3 2.2 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 ADV22662.1 - 0.09 13.3 0.0 0.31 11.6 0.0 1.9 1 0 0 1 1 1 0 AAA domain DUF87 PF01935.17 ADV22662.1 - 0.11 12.6 1.5 0.18 11.9 0.4 1.8 2 0 0 2 2 2 0 Helicase HerA, central domain cobW PF02492.19 ADV22662.1 - 0.21 11.2 0.7 0.36 10.4 0.0 1.8 2 0 0 2 2 1 0 CobW/HypB/UreG, nucleotide-binding domain Oxysterol_BP PF01237.18 ADV22663.1 - 1.2e-80 271.1 0.0 1.3e-78 264.5 0.0 2.0 1 1 0 1 1 1 1 Oxysterol-binding protein NDUFA12 PF05071.16 ADV22664.1 - 2.4e-31 108.5 1.4 3.2e-31 108.0 1.4 1.2 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 Ribosomal_L28 PF00830.19 ADV22666.1 - 3.9e-05 23.8 0.2 6.3e-05 23.1 0.2 1.3 1 0 0 1 1 1 1 Ribosomal L28 family UQ_con PF00179.26 ADV22667.1 - 1.3e-47 161.0 0.0 1.4e-47 160.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 ADV22667.1 - 0.00063 19.5 0.0 0.00083 19.1 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 ADV22667.1 - 0.012 15.4 0.1 0.027 14.3 0.1 1.6 1 1 0 1 1 1 0 UEV domain RWD PF05773.22 ADV22667.1 - 0.072 13.4 0.5 0.1 12.9 0.5 1.5 1 1 0 1 1 1 0 RWD domain MT-A70 PF05063.14 ADV22668.1 - 2.8e-48 164.1 0.1 5.9e-48 163.0 0.1 1.5 1 1 0 1 1 1 1 MT-A70 Amidohydro_3 PF07969.11 ADV22669.1 - 5.2e-12 46.0 0.2 2.2e-10 40.6 0.0 2.6 2 0 0 2 2 2 1 Amidohydrolase family Amidohydro_1 PF01979.20 ADV22669.1 - 1.6e-11 44.2 0.0 4.9e-11 42.5 0.0 1.7 1 1 0 1 1 1 1 Amidohydrolase family TOM6p PF15184.6 ADV22669.1 - 0.077 12.8 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 Mitochondrial import receptor subunit TOM6 homolog TPR_2 PF07719.17 ADV22670.1 - 1.1e-25 87.6 13.5 0.00028 20.8 0.3 9.9 10 0 0 10 10 10 4 Tetratricopeptide repeat ANAPC3 PF12895.7 ADV22670.1 - 1e-22 80.1 14.6 3.9e-10 39.8 0.0 6.3 5 1 1 6 6 6 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 ADV22670.1 - 4.5e-22 76.9 13.9 5.1e-07 29.3 0.0 8.4 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_8 PF13181.6 ADV22670.1 - 9.9e-20 69.1 8.4 0.00065 19.7 0.0 8.1 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_11 PF13414.6 ADV22670.1 - 1.7e-15 56.4 1.6 3.4e-08 33.0 0.0 6.5 5 1 1 6 6 6 2 TPR repeat TPR_16 PF13432.6 ADV22670.1 - 4e-15 56.2 16.5 4.3e-05 24.1 0.0 6.8 6 1 1 7 7 7 3 Tetratricopeptide repeat TPR_12 PF13424.6 ADV22670.1 - 3.1e-13 49.8 17.5 9.8e-07 29.0 0.1 6.9 6 1 2 8 8 8 4 Tetratricopeptide repeat TPR_7 PF13176.6 ADV22670.1 - 1.3e-09 37.4 11.1 0.028 14.4 0.0 6.0 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_10 PF13374.6 ADV22670.1 - 2.7e-09 36.6 11.3 0.002 17.9 0.2 5.3 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.6 ADV22670.1 - 3e-07 30.4 5.3 0.0028 17.9 0.0 5.2 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_9 PF13371.6 ADV22670.1 - 3.7e-05 23.8 4.3 0.59 10.3 0.1 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 ADV22670.1 - 6.3e-05 23.5 14.1 0.49 11.4 0.0 7.6 7 2 2 9 9 7 1 Tetratricopeptide repeat TPR_19 PF14559.6 ADV22670.1 - 0.00047 20.6 7.2 20 5.8 0.1 6.2 6 1 1 7 7 7 0 Tetratricopeptide repeat TPR_MalT PF17874.1 ADV22670.1 - 0.017 14.5 0.1 0.044 13.2 0.1 1.7 1 0 0 1 1 1 0 MalT-like TPR region TPR_3 PF07720.12 ADV22670.1 - 0.046 13.7 6.2 4.1 7.5 0.0 4.3 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 ADV22670.1 - 0.18 12.5 9.7 10 7.0 0.1 5.5 5 0 0 5 5 5 0 Tetratricopeptide repeat Atx10homo_assoc PF09759.9 ADV22671.1 - 1.7e-24 85.7 0.0 4.9e-24 84.2 0.0 1.7 2 0 0 2 2 2 1 Spinocerebellar ataxia type 10 protein domain His_Phos_2 PF00328.22 ADV22672.1 - 2.7e-78 264.0 0.0 4.9e-78 263.2 0.0 1.5 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) PPIP5K2_N PF18086.1 ADV22672.1 - 1.3e-29 102.2 0.1 3.9e-29 100.6 0.0 1.9 2 0 0 2 2 2 1 Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain RimK PF08443.11 ADV22672.1 - 0.0012 18.5 0.0 0.002 17.7 0.0 1.3 1 0 0 1 1 1 1 RimK-like ATP-grasp domain UBA_e1_thiolCys PF10585.9 ADV22672.1 - 0.16 11.8 2.4 0.19 11.6 1.0 1.8 2 0 0 2 2 2 0 Ubiquitin-activating enzyme active site Ins134_P3_kin PF05770.11 ADV22672.1 - 0.18 11.3 0.0 0.54 9.7 0.0 1.8 1 0 0 1 1 1 0 Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain DUF1542 PF07564.11 ADV22673.1 - 0.16 12.1 2.4 0.41 10.8 2.4 1.6 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1542) PSP1 PF04468.12 ADV22674.1 - 2.1e-25 88.8 1.6 3.5e-25 88.1 1.6 1.3 1 0 0 1 1 1 1 PSP1 C-terminal conserved region SUIM_assoc PF16619.5 ADV22674.1 - 0.0007 19.6 1.4 0.064 13.3 0.0 4.0 5 1 0 5 5 5 1 Unstructured region C-term to UIM in Ataxin3 SIR2 PF02146.17 ADV22675.1 - 5.1e-27 94.9 0.0 1.3e-16 61.0 0.0 2.3 2 0 0 2 2 2 2 Sir2 family TPP_enzyme_M PF00205.22 ADV22675.1 - 0.034 13.9 0.0 0.23 11.2 0.0 2.1 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain Glyco_hydro_47 PF01532.20 ADV22676.1 - 9.4e-155 516.0 0.0 1.1e-154 515.8 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Elong_Iki1 PF10483.9 ADV22677.1 - 3.4e-09 36.7 0.0 2.7e-08 33.7 0.0 2.1 1 1 0 1 1 1 1 Elongator subunit Iki1 Peptidase_M1 PF01433.20 ADV22678.1 - 1.9e-40 138.8 0.1 2.5e-40 138.4 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M1 domain Leuk-A4-hydro_C PF09127.11 ADV22678.1 - 2.1e-35 121.2 0.0 4.2e-35 120.2 0.0 1.5 1 0 0 1 1 1 1 Leukotriene A4 hydrolase, C-terminal Peptidase_M1_N PF17900.1 ADV22678.1 - 7.4e-25 88.2 0.0 1.1e-24 87.6 0.0 1.2 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Peptidase_M61 PF05299.12 ADV22678.1 - 0.26 11.7 2.1 8 6.9 2.1 2.4 1 1 0 1 1 1 0 M61 glycyl aminopeptidase Lac_bphage_repr PF06543.12 ADV22678.1 - 0.75 9.8 6.2 0.11 12.5 0.9 2.2 2 0 0 2 2 2 0 Lactococcus bacteriophage repressor Peptidase_M16_C PF05193.21 ADV22679.1 - 3.1e-44 151.2 0.0 4.4e-44 150.7 0.0 1.2 1 0 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 ADV22679.1 - 1.3e-36 125.8 0.0 2e-36 125.2 0.0 1.3 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Claudin_3 PF06653.11 ADV22680.1 - 0.00082 19.4 0.5 0.00082 19.4 0.5 1.6 2 0 0 2 2 2 1 Tight junction protein, Claudin-like DUF4293 PF14126.6 ADV22680.1 - 0.091 13.0 0.3 0.091 13.0 0.3 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4293) WES_acyltransf PF03007.16 ADV22682.1 - 0.17 11.6 0.6 0.24 11.1 0.6 1.2 1 0 0 1 1 1 0 Wax ester synthase-like Acyl-CoA acyltransferase domain Mitofilin PF09731.9 ADV22682.1 - 7.6 5.2 9.9 8.4 5.1 9.9 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein PAT1 PF09770.9 ADV22682.1 - 7.9 4.6 9.6 8.2 4.6 9.6 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 UPF0016 PF01169.19 ADV22684.1 - 9.4e-38 128.4 27.3 6.1e-21 74.5 11.4 2.1 2 0 0 2 2 2 2 Uncharacterized protein family UPF0016 WaaY PF06176.11 ADV22685.1 - 0.046 13.3 0.0 0.07 12.7 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) DUF3535 PF12054.8 ADV22686.1 - 7.6e-99 331.9 0.0 3.1e-95 320.0 0.0 3.9 4 0 0 4 4 4 1 Domain of unknown function (DUF3535) SNF2_N PF00176.23 ADV22686.1 - 1.6e-62 211.3 0.0 2.7e-62 210.5 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ADV22686.1 - 4.3e-16 59.2 0.0 1.1e-15 58.0 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HEAT PF02985.22 ADV22686.1 - 3.2e-14 51.8 18.7 0.018 15.3 0.3 11.0 11 0 0 11 11 11 4 HEAT repeat HEAT_2 PF13646.6 ADV22686.1 - 8.1e-06 26.2 14.8 0.41 11.1 0.1 7.4 7 2 1 8 8 6 3 HEAT repeats ResIII PF04851.15 ADV22686.1 - 3.4e-05 23.9 0.0 7.7e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HEAT_EZ PF13513.6 ADV22686.1 - 0.00025 21.5 15.7 0.34 11.5 0.3 8.4 8 2 1 9 9 8 1 HEAT-like repeat Vac14_Fab1_bd PF12755.7 ADV22686.1 - 0.00064 20.3 0.0 4.7 7.9 0.0 4.0 3 1 1 4 4 4 1 Vacuolar 14 Fab1-binding region TAF6_C PF07571.13 ADV22686.1 - 0.0021 18.3 2.0 2.4 8.6 0.0 5.1 5 1 0 5 5 4 1 TAF6 C-terminal HEAT repeat domain DUF3385 PF11865.8 ADV22686.1 - 0.041 13.8 0.0 0.32 10.9 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3385) IFRD PF05004.13 ADV22686.1 - 0.047 12.8 1.7 8 5.5 0.0 3.8 4 0 0 4 4 4 0 Interferon-related developmental regulator (IFRD) UME PF08064.13 ADV22686.1 - 0.052 13.5 4.1 20 5.2 0.0 5.3 4 2 2 6 6 6 0 UME (NUC010) domain Adaptin_N PF01602.20 ADV22686.1 - 0.12 10.9 2.4 0.68 8.4 0.0 2.7 4 0 0 4 4 4 0 Adaptin N terminal region PLDc_3 PF13918.6 ADV22688.1 - 0.062 13.0 0.0 0.1 12.2 0.0 1.3 1 0 0 1 1 1 0 PLD-like domain G_glu_transpept PF01019.21 ADV22690.1 - 0.025 13.4 0.1 0.035 12.9 0.1 1.1 1 0 0 1 1 1 0 Gamma-glutamyltranspeptidase MFS_1 PF07690.16 ADV22691.1 - 4e-41 141.1 33.9 4e-41 141.1 33.9 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_3 PF05977.13 ADV22691.1 - 0.00027 19.5 8.2 0.00027 19.5 8.2 1.8 2 0 0 2 2 2 1 Transmembrane secretion effector PhoR PF11808.8 ADV22691.1 - 0.31 11.5 0.0 0.31 11.5 0.0 4.8 6 0 0 6 6 6 0 Phosphate regulon sensor protein PhoR SH3_2 PF07653.17 ADV22692.1 - 0.27 10.9 1.0 22 4.8 0.3 2.4 2 0 0 2 2 2 0 Variant SH3 domain LsmAD PF06741.13 ADV22693.1 - 6e-26 90.8 1.7 6e-26 90.8 1.7 2.3 2 0 0 2 2 2 1 LsmAD domain Phosducin PF02114.16 ADV22693.1 - 0.49 9.3 3.3 0.69 8.8 0.1 2.0 2 0 0 2 2 2 0 Phosducin DUF3395 PF11875.8 ADV22699.1 - 5.1e-41 140.2 0.6 9.3e-41 139.3 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF3395) DnaJ PF00226.31 ADV22699.1 - 3.6e-19 68.7 0.6 7.1e-19 67.7 0.6 1.5 1 0 0 1 1 1 1 DnaJ domain TPT PF03151.16 ADV22700.1 - 8.5e-24 84.4 16.7 1.1e-23 84.1 16.7 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family CBFD_NFYB_HMF PF00808.23 ADV22701.1 - 3.5e-06 27.2 0.0 5e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone PBP_N PF17093.5 ADV22701.1 - 3.4 7.9 6.4 7.2 6.9 6.4 1.5 1 0 0 1 1 1 0 Penicillin-binding protein N-terminus SAC3_GANP PF03399.16 ADV22702.1 - 2.9e-68 230.4 0.1 4.3e-68 229.9 0.1 1.2 1 0 0 1 1 1 1 SAC3/GANP family DUF3456 PF11938.8 ADV22702.1 - 0.069 13.7 0.3 1.8 9.1 0.1 2.4 2 0 0 2 2 2 0 TLR4 regulator and MIR-interacting MSAP DUF4834 PF16118.5 ADV22703.1 - 0.12 13.3 0.0 1.5 9.9 0.0 2.8 3 1 0 3 3 3 0 Domain of unknown function (DUF4834) PHR PF08005.12 ADV22703.1 - 0.12 13.0 0.4 0.25 12.0 0.0 1.6 2 0 0 2 2 2 0 PHR domain WH1 PF00568.23 ADV22704.1 - 1.8e-21 76.2 0.1 3e-21 75.4 0.1 1.3 1 0 0 1 1 1 1 WH1 domain PBD PF00786.28 ADV22704.1 - 4.2e-10 39.8 0.3 4.2e-10 39.8 0.3 1.8 2 0 0 2 2 2 1 P21-Rho-binding domain WH2 PF02205.20 ADV22704.1 - 0.0012 18.6 0.1 0.0029 17.4 0.1 1.7 1 0 0 1 1 1 1 WH2 motif DCP1 PF06058.13 ADV22704.1 - 0.0018 18.2 0.0 0.0029 17.5 0.0 1.2 1 0 0 1 1 1 1 Dcp1-like decapping family ABC_export PF16962.5 ADV22704.1 - 1.5 7.2 2.0 1.9 6.8 2.0 1.1 1 0 0 1 1 1 0 Putative ABC exporter RraB PF06877.11 ADV22704.1 - 8.5 7.2 7.2 16 6.3 0.6 3.0 3 0 0 3 3 3 0 Regulator of ribonuclease activity B CLASP_N PF12348.8 ADV22706.1 - 3.1e-17 62.9 0.0 4.6e-17 62.4 0.0 1.3 1 0 0 1 1 1 1 CLASP N terminal SANT_DAMP1_like PF16282.5 ADV22707.1 - 2.3e-26 91.8 1.2 3.9e-26 91.1 1.2 1.4 1 0 0 1 1 1 1 SANT/Myb-like domain of DAMP1 TolA_bind_tri PF16331.5 ADV22707.1 - 2.6 8.2 9.0 0.72 10.0 3.2 2.3 2 0 0 2 2 2 0 TolA binding protein trimerisation DJ-1_PfpI PF01965.24 ADV22708.1 - 6.6e-14 52.0 0.0 3.3e-13 49.8 0.0 2.1 1 1 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.5 ADV22708.1 - 8.6e-14 51.7 0.0 1.1e-13 51.3 0.0 1.1 1 0 0 1 1 1 1 ThiJ/PfpI family-like Acetyltransf_1 PF00583.25 ADV22710.1 - 2.3e-13 50.4 0.0 2.8e-13 50.1 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ADV22710.1 - 5e-11 42.6 0.0 5.9e-11 42.4 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ADV22710.1 - 2e-07 30.9 0.0 3e-07 30.3 0.0 1.3 1 1 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.7 ADV22710.1 - 3e-06 27.6 0.0 4.2e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 ADV22710.1 - 0.003 17.0 0.3 0.003 17.0 0.3 1.7 2 0 0 2 2 2 1 Putative acetyl-transferase Acetyltransf_9 PF13527.7 ADV22710.1 - 0.0072 16.4 0.1 0.017 15.2 0.1 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 ADV22710.1 - 0.023 14.8 0.0 0.031 14.4 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 ADV22710.1 - 0.068 13.8 0.0 0.085 13.5 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain RNA_pol_A_bac PF01000.26 ADV22711.1 - 3.5e-25 88.5 0.0 6.2e-25 87.7 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 ADV22711.1 - 4.5e-15 54.8 0.0 6.1e-15 54.4 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Pico_P2A PF00947.19 ADV22711.1 - 0.076 13.0 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Picornavirus core protein 2A DUF1998 PF09369.10 ADV22711.1 - 0.11 13.3 0.2 0.24 12.2 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1998) HTH_9 PF08221.11 ADV22713.1 - 1.6e-15 56.9 3.0 8.3e-14 51.4 0.1 3.7 4 0 0 4 4 4 1 RNA polymerase III subunit RPC82 helix-turn-helix domain RNA_pol_Rpc82 PF05645.13 ADV22713.1 - 1.4e-12 47.9 0.5 1.9e-09 37.7 0.1 2.5 2 0 0 2 2 2 2 RNA polymerase III subunit RPC82 TFIIE_alpha PF02002.17 ADV22713.1 - 0.016 15.0 0.0 0.37 10.7 0.0 2.5 2 0 0 2 2 2 0 TFIIE alpha subunit MarR_2 PF12802.7 ADV22713.1 - 0.026 14.4 0.9 1.1 9.2 0.1 2.9 2 0 0 2 2 2 0 MarR family HTH_IclR PF09339.10 ADV22713.1 - 0.076 12.8 2.1 0.19 11.5 0.2 2.7 2 1 0 2 2 2 0 IclR helix-turn-helix domain DprA_WH PF17782.1 ADV22713.1 - 0.46 10.6 4.6 0.51 10.5 0.5 2.8 3 0 0 3 3 3 0 DprA winged helix domain LpqV PF17301.2 ADV22714.1 - 0.011 16.0 0.4 0.011 16.0 0.4 2.1 2 0 0 2 2 2 0 Putative lipoprotein LpqV Rax2 PF12768.7 ADV22714.1 - 0.069 12.6 0.2 0.17 11.3 0.2 1.6 1 0 0 1 1 1 0 Cortical protein marker for cell polarity Pkinase PF00069.25 ADV22715.1 - 1.1e-41 143.0 0.1 5e-22 78.5 0.1 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ADV22715.1 - 4.4e-12 45.8 0.2 8.7e-09 35.0 0.1 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Glyoxal_oxid_N PF07250.11 ADV22716.1 - 6.3e-37 127.1 1.3 2.8e-34 118.4 0.3 3.4 2 1 0 2 2 2 2 Glyoxal oxidase N-terminus DUF1929 PF09118.11 ADV22716.1 - 9e-21 74.0 0.0 2.4e-20 72.6 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1929) L51_S25_CI-B8 PF05047.16 ADV22717.1 - 6.1e-05 22.8 0.1 0.0001 22.1 0.1 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain TIM PF00121.18 ADV22718.1 - 7.7e-89 297.2 0.1 8.8e-89 297.0 0.1 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase Ribosomal_L22 PF00237.19 ADV22719.1 - 1.3e-22 80.0 0.6 1.8e-22 79.5 0.6 1.2 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e EamA PF00892.20 ADV22720.1 - 3.7e-13 49.8 25.8 9.6e-12 45.2 12.4 2.2 2 0 0 2 2 2 2 EamA-like transporter family DUF3760 PF12586.8 ADV22721.1 - 1e-17 64.0 8.7 1.2e-16 60.6 6.9 3.0 2 0 0 2 2 2 1 Protein of unknown function (DUF3760) Glyoxalase PF00903.25 ADV22722.1 - 0.13 12.5 0.0 0.23 11.7 0.0 1.5 1 1 0 1 1 1 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily AMP-binding PF00501.28 ADV22723.1 - 2e-36 125.5 0.0 3.9e-36 124.6 0.0 1.5 1 1 0 1 1 1 1 AMP-binding enzyme ACAS_N PF16177.5 ADV22723.1 - 0.0002 21.2 6.2 0.00046 20.0 6.2 1.7 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus AMP-binding_C PF13193.6 ADV22723.1 - 0.099 13.6 0.1 0.26 12.3 0.1 1.7 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain Pro_dh PF01619.18 ADV22724.1 - 1e-48 166.4 0.0 3.8e-48 164.6 0.0 1.8 1 1 0 1 1 1 1 Proline dehydrogenase Pro_dh PF01619.18 ADV22725.1 - 3.2e-47 161.5 0.0 8.4e-47 160.1 0.0 1.7 1 1 0 1 1 1 1 Proline dehydrogenase TPM_phosphatase PF04536.14 ADV22725.1 - 0.054 13.7 0.1 6.7 6.9 0.0 2.5 3 0 0 3 3 3 0 TPM domain Serglycin PF04360.12 ADV22725.1 - 3.1 7.7 4.8 6.7 6.6 4.8 1.5 1 0 0 1 1 1 0 Serglycin Kinesin PF00225.23 ADV22726.1 - 6.9e-82 275.0 2.8 1e-81 274.5 0.0 2.6 3 1 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 ADV22726.1 - 1e-14 54.7 0.0 8.9e-12 45.2 0.0 3.0 3 0 0 3 3 3 2 Microtubule binding DUF5476 PF17570.2 ADV22726.1 - 0.024 15.0 0.3 0.14 12.5 0.3 2.3 1 0 0 1 1 1 0 Family of unknown function (DUF5476) CDC45 PF02724.14 ADV22726.1 - 2.7 6.2 35.3 0.11 10.8 23.9 2.1 2 0 0 2 2 2 0 CDC45-like protein GFO_IDH_MocA PF01408.22 ADV22727.1 - 1.2e-13 52.0 0.0 1.9e-13 51.3 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold UreF PF01730.16 ADV22728.1 - 8.7e-20 71.7 0.0 1.4e-19 71.0 0.0 1.2 1 0 0 1 1 1 1 UreF ABC_tran PF00005.27 ADV22729.1 - 6.6e-17 62.3 0.0 2.3e-16 60.5 0.0 1.9 1 1 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ADV22729.1 - 1.4e-09 38.3 0.6 0.001 19.0 0.1 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ADV22729.1 - 0.00068 19.3 0.0 0.0014 18.4 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_25 PF13481.6 ADV22729.1 - 0.0007 19.2 0.0 0.00095 18.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 ADV22729.1 - 0.0019 18.1 0.0 0.0033 17.4 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase Arf PF00025.21 ADV22729.1 - 0.0078 15.7 0.1 0.015 14.7 0.1 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family PduV-EutP PF10662.9 ADV22729.1 - 0.011 15.4 0.0 0.019 14.7 0.0 1.3 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_23 PF13476.6 ADV22729.1 - 0.042 14.4 0.0 0.075 13.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 ADV22729.1 - 0.046 14.0 0.1 0.093 13.0 0.1 1.5 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 ADV22729.1 - 0.05 13.7 0.2 0.11 12.6 0.2 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_16 PF13191.6 ADV22729.1 - 0.069 13.5 0.0 0.11 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain NACHT PF05729.12 ADV22729.1 - 0.1 12.5 0.0 0.3 11.0 0.0 1.9 2 0 0 2 2 2 0 NACHT domain CLP1_P PF16575.5 ADV22729.1 - 0.12 12.1 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop DUF3584 PF12128.8 ADV22729.1 - 0.17 9.3 0.1 0.23 8.9 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) AAA_13 PF13166.6 ADV22729.1 - 0.25 10.0 0.0 0.35 9.4 0.0 1.2 1 0 0 1 1 1 0 AAA domain SRP54 PF00448.22 ADV22729.1 - 0.25 10.9 0.1 0.38 10.3 0.1 1.2 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_15 PF13175.6 ADV22729.1 - 0.31 10.7 0.0 0.43 10.2 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain Zn_clus PF00172.18 ADV22731.1 - 1.1e-05 25.4 10.2 2.2e-05 24.5 10.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ArfGap PF01412.18 ADV22732.1 - 2.2e-41 140.6 0.8 4.2e-41 139.7 0.8 1.5 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf DDE_1 PF03184.19 ADV22733.1 - 0.00061 19.5 0.0 0.00074 19.2 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease IBB PF01749.20 ADV22733.1 - 0.0079 16.6 0.2 0.012 16.1 0.2 1.3 1 0 0 1 1 1 1 Importin beta binding domain Mlh1_C PF16413.5 ADV22735.1 - 4.8e-88 295.0 0.0 1.1e-87 293.9 0.0 1.6 1 0 0 1 1 1 1 DNA mismatch repair protein Mlh1 C-terminus DNA_mis_repair PF01119.19 ADV22735.1 - 2.3e-34 117.6 0.0 4e-34 116.8 0.0 1.4 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 ADV22735.1 - 1.6e-15 57.1 0.0 3.2e-15 56.1 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 ADV22735.1 - 4.2e-07 30.5 0.0 9.4e-07 29.3 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase ATP-synt_10 PF05176.14 ADV22736.1 - 4.8e-50 170.2 0.0 7.1e-48 163.1 0.0 2.0 1 1 0 1 1 1 1 ATP10 protein DUF2709 PF10915.8 ADV22736.1 - 0.071 12.4 0.0 0.1 11.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2709) Redoxin PF08534.10 ADV22736.1 - 0.16 11.6 0.0 0.65 9.7 0.0 1.9 1 1 0 1 1 1 0 Redoxin IU_nuc_hydro PF01156.19 ADV22737.1 - 3.1e-63 214.2 0.0 3.9e-63 213.8 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase Glyco_hydro_63 PF03200.16 ADV22738.1 - 1.4e-08 33.9 6.2 1.3e-05 24.2 0.3 4.7 4 1 0 4 4 4 2 Glycosyl hydrolase family 63 C-terminal domain Auto_anti-p27 PF06677.12 ADV22739.1 - 2.3e-25 88.5 3.4 3.1e-12 46.4 0.2 2.3 2 0 0 2 2 2 2 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) DASH_Dad1 PF08649.10 ADV22740.1 - 8.8e-24 83.5 1.2 1.1e-23 83.1 1.2 1.1 1 0 0 1 1 1 1 DASH complex subunit Dad1 DASH_Dad4 PF08650.10 ADV22740.1 - 0.0019 18.1 0.1 0.0026 17.7 0.1 1.2 1 0 0 1 1 1 1 DASH complex subunit Dad4 MFS_1 PF07690.16 ADV22741.1 - 6.4e-16 58.2 42.3 4.4e-14 52.2 41.5 2.8 1 1 0 1 1 1 1 Major Facilitator Superfamily OATP PF03137.20 ADV22741.1 - 2.1e-06 26.3 8.8 3.6e-05 22.3 0.5 2.9 3 0 0 3 3 3 2 Organic Anion Transporter Polypeptide (OATP) family HP_OMP PF01856.17 ADV22741.1 - 0.17 11.9 0.6 10 6.2 0.0 3.1 3 0 0 3 3 3 0 Helicobacter outer membrane protein polyprenyl_synt PF00348.17 ADV22742.1 - 1.1e-96 322.9 0.0 1.5e-96 322.4 0.0 1.2 1 0 0 1 1 1 1 Polyprenyl synthetase TRAM_LAG1_CLN8 PF03798.16 ADV22743.1 - 1.9e-36 125.7 28.9 1.9e-36 125.7 28.9 1.5 2 0 0 2 2 2 1 TLC domain TRAM1 PF08390.11 ADV22743.1 - 2.1e-15 56.1 0.1 2.1e-15 56.1 0.1 2.4 2 0 0 2 2 2 1 TRAM1-like protein TRAM_LAG1_CLN8 PF03798.16 ADV22744.1 - 4.2e-38 131.1 24.5 4.2e-38 131.1 24.5 2.6 2 1 1 3 3 3 1 TLC domain TRAM1 PF08390.11 ADV22744.1 - 6.2e-16 57.8 0.4 6.2e-16 57.8 0.4 2.7 3 0 0 3 3 3 1 TRAM1-like protein Condensation PF00668.20 ADV22745.1 - 0.00089 18.0 0.0 0.0014 17.4 0.0 1.2 1 0 0 1 1 1 1 Condensation domain PhoD PF09423.10 ADV22747.1 - 0.00041 19.5 0.0 0.014 14.4 0.0 2.5 1 1 0 1 1 1 1 PhoD-like phosphatase TrkH PF02386.16 ADV22748.1 - 0.086 11.3 0.6 0.12 10.7 0.0 1.5 2 0 0 2 2 2 0 Cation transport protein DUF4381 PF14316.6 ADV22748.1 - 0.11 12.7 0.0 0.24 11.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) DUF1180 PF06679.12 ADV22748.1 - 4.4 7.7 15.4 0.18 12.2 6.5 2.7 2 2 0 2 2 2 0 Protein of unknown function (DUF1180) MGC-24 PF05283.11 ADV22748.1 - 5 7.6 17.3 0.06 13.8 6.7 2.8 2 2 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin SUI1 PF01253.22 ADV22749.1 - 7.2e-22 77.7 2.7 7.2e-22 77.7 2.7 1.5 2 0 0 2 2 2 1 Translation initiation factor SUI1 DHHC PF01529.20 ADV22750.1 - 6e-34 117.0 5.6 6e-34 117.0 5.6 1.8 2 1 0 2 2 2 1 DHHC palmitoyltransferase Kinetochor_Ybp2 PF08568.10 ADV22751.1 - 0.0017 16.9 0.0 0.023 13.2 0.0 2.1 2 0 0 2 2 2 1 Uncharacterised protein family, YAP/Alf4/glomulin HEAT_2 PF13646.6 ADV22751.1 - 0.11 12.8 0.3 1.9 8.9 0.1 2.6 2 0 0 2 2 2 0 HEAT repeats IFRD PF05004.13 ADV22751.1 - 0.13 11.4 0.2 0.19 10.8 0.2 1.2 1 0 0 1 1 1 0 Interferon-related developmental regulator (IFRD) DNA_ligase_A_M PF01068.21 ADV22752.1 - 1e-16 61.2 0.0 2.7e-16 59.8 0.0 1.7 2 1 0 2 2 2 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 ADV22752.1 - 4.8e-10 40.0 0.0 1.1e-09 38.9 0.0 1.6 1 0 0 1 1 1 1 DNA ligase N terminus RNA_ligase PF09414.10 ADV22752.1 - 0.036 14.4 0.0 0.063 13.6 0.0 1.4 1 0 0 1 1 1 0 RNA ligase Zn_clus PF00172.18 ADV22753.1 - 0.0006 19.9 5.7 0.0013 18.8 5.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AAA PF00004.29 ADV22754.1 - 2.5e-41 141.2 0.0 4.2e-41 140.5 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 ADV22754.1 - 1.5e-10 40.9 0.1 3e-10 39.9 0.1 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 ADV22754.1 - 1.9e-09 37.2 0.5 3.8e-09 36.2 0.5 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_2 PF07724.14 ADV22754.1 - 3.3e-06 27.3 0.0 5.8e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 ADV22754.1 - 3e-05 23.3 0.0 4.9e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_22 PF13401.6 ADV22754.1 - 0.00011 22.5 0.4 0.018 15.4 0.4 2.4 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 ADV22754.1 - 0.00019 21.4 0.2 0.0011 19.0 0.2 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ADV22754.1 - 0.00031 21.2 0.1 0.0098 16.3 0.1 2.3 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 ADV22754.1 - 0.00068 19.4 0.0 0.0012 18.6 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_3 PF07726.11 ADV22754.1 - 0.0036 17.2 0.1 0.015 15.1 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 ADV22754.1 - 0.0036 17.8 0.0 0.0058 17.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 ADV22754.1 - 0.0082 16.3 0.0 0.016 15.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 ADV22754.1 - 0.01 15.9 0.0 0.021 14.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 ADV22754.1 - 0.011 15.1 0.2 0.25 10.7 0.1 2.2 1 1 0 2 2 2 0 KaiC SKI PF01202.22 ADV22754.1 - 0.024 14.8 0.0 3.3 7.8 0.0 2.3 2 0 0 2 2 2 0 Shikimate kinase IstB_IS21 PF01695.17 ADV22754.1 - 0.031 14.0 0.0 0.059 13.1 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein Prot_ATP_OB_N PF17758.1 ADV22754.1 - 0.035 13.7 0.4 0.16 11.6 0.0 2.3 2 0 0 2 2 2 0 Proteasomal ATPase OB N-terminal domain TIP49 PF06068.13 ADV22754.1 - 0.05 12.8 0.0 0.086 12.0 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain NACHT PF05729.12 ADV22754.1 - 0.053 13.4 0.2 0.8 9.6 0.1 2.3 1 1 1 2 2 2 0 NACHT domain AAA_25 PF13481.6 ADV22754.1 - 0.061 12.9 0.5 3 7.4 0.1 2.4 1 1 1 2 2 2 0 AAA domain AAA_28 PF13521.6 ADV22754.1 - 0.08 13.2 0.0 0.18 12.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.9 ADV22754.1 - 0.11 11.7 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) RNA_helicase PF00910.22 ADV22754.1 - 0.12 12.7 0.0 0.23 11.8 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_24 PF13479.6 ADV22754.1 - 0.13 11.9 0.3 0.32 10.7 0.3 1.7 1 1 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 ADV22754.1 - 0.14 11.9 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Mg_chelatase PF01078.21 ADV22754.1 - 0.14 11.6 0.0 0.26 10.7 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI UQ_con PF00179.26 ADV22755.1 - 1e-33 116.0 0.0 1e-32 112.7 0.0 1.9 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme ANTH PF07651.16 ADV22756.1 - 1.1e-74 251.0 0.0 1.1e-74 251.0 0.0 3.4 2 1 1 3 3 3 1 ANTH domain I_LWEQ PF01608.17 ADV22756.1 - 2.6e-54 183.6 8.0 2.6e-54 183.6 8.0 5.9 5 1 0 7 7 7 1 I/LWEQ domain ENTH PF01417.20 ADV22756.1 - 0.0027 17.8 0.0 0.016 15.3 0.0 2.4 1 0 0 1 1 1 1 ENTH domain FAA_hydro_N_2 PF18288.1 ADV22756.1 - 0.14 12.6 3.6 0.35 11.3 0.7 3.4 2 1 0 2 2 2 0 Fumarylacetoacetase N-terminal domain 2 Ribosom_S30AE_C PF16321.5 ADV22756.1 - 0.23 11.2 0.9 0.68 9.7 0.1 2.3 2 0 0 2 2 2 0 Sigma 54 modulation/S30EA ribosomal protein C terminus ATP-synt_ab PF00006.25 ADV22756.1 - 0.24 11.0 1.1 0.66 9.6 1.1 1.7 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain Peptidase_S15 PF02129.18 ADV22756.1 - 2.1 7.9 8.8 6.6 6.2 8.8 1.8 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) VHS PF00790.19 ADV22758.1 - 5.1e-35 120.4 1.1 8.6e-35 119.6 0.0 1.8 2 0 0 2 2 2 1 VHS domain FYVE PF01363.21 ADV22758.1 - 3.2e-17 62.4 5.5 5.9e-17 61.6 5.5 1.5 1 0 0 1 1 1 1 FYVE zinc finger UIM PF02809.20 ADV22758.1 - 2.1e-05 24.1 14.2 0.0022 17.8 2.1 2.8 2 0 0 2 2 2 2 Ubiquitin interaction motif FYVE_2 PF02318.16 ADV22758.1 - 0.02 15.1 3.1 0.02 15.1 3.1 2.3 2 0 0 2 2 2 0 FYVE-type zinc finger OrfB_Zn_ribbon PF07282.11 ADV22758.1 - 3.8 7.5 5.1 2.3 8.2 2.5 2.0 1 1 1 2 2 2 0 Putative transposase DNA-binding domain RNA_pol_Rpb1_1 PF04997.12 ADV22759.1 - 8.5e-104 347.2 0.0 1.2e-103 346.7 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.17 ADV22759.1 - 1.6e-98 329.4 0.1 2.4e-98 328.8 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 ADV22759.1 - 1.2e-72 243.5 0.0 2.2e-72 242.7 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_6 PF04992.14 ADV22759.1 - 4.2e-62 209.4 0.1 7.9e-62 208.5 0.1 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_3 PF04983.18 ADV22759.1 - 1.2e-49 168.3 0.0 2e-48 164.3 0.0 2.4 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_7 PF04990.12 ADV22759.1 - 8e-38 129.5 0.2 1.9e-37 128.3 0.2 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 7 RNA_pol_Rpb1_4 PF05000.17 ADV22759.1 - 3.9e-35 120.1 0.1 8.4e-35 119.0 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_R PF05001.13 ADV22759.1 - 7.5e-20 70.2 226.0 0.0042 17.4 11.0 15.8 7 4 10 20 20 20 15 RNA polymerase Rpb1 C-terminal repeat AcetDehyd-dimer PF09290.11 ADV22759.1 - 0.1 12.8 2.3 0.099 12.8 0.4 1.9 2 0 0 2 2 2 0 Prokaryotic acetaldehyde dehydrogenase, dimerisation NAP PF00956.18 ADV22761.1 - 3.3e-93 311.8 6.6 4.6e-93 311.3 6.6 1.2 1 0 0 1 1 1 1 Nucleosome assembly protein (NAP) G-alpha PF00503.20 ADV22762.1 - 1.1e-102 343.8 0.1 1.3e-102 343.6 0.1 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ADV22762.1 - 1.8e-15 56.9 0.1 4e-10 39.4 0.0 2.4 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ADV22762.1 - 6.3e-05 22.4 0.1 0.01 15.2 0.0 2.3 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 ADV22762.1 - 0.00027 21.1 0.0 0.64 10.2 0.0 2.4 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase FtsK_SpoIIIE PF01580.18 ADV22762.1 - 0.026 13.9 0.0 0.059 12.7 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family MMR_HSR1 PF01926.23 ADV22762.1 - 0.047 13.8 0.0 6.9 6.8 0.0 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_21 PF13304.6 ADV22762.1 - 0.06 13.1 0.1 0.21 11.3 0.0 1.9 3 0 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system GTP_EFTU PF00009.27 ADV22762.1 - 0.06 12.9 0.0 0.33 10.5 0.1 2.0 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain Ras PF00071.22 ADV22762.1 - 0.087 12.4 0.0 10 5.7 0.0 2.5 2 1 0 2 2 2 0 Ras family CdiA_C_tRNase PF18664.1 ADV22762.1 - 0.11 12.7 0.2 0.2 11.9 0.2 1.4 1 0 0 1 1 1 0 CdiA C-terminal tRNase domain AAA_29 PF13555.6 ADV22762.1 - 0.18 11.6 0.0 0.35 10.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Fungal_trans PF04082.18 ADV22764.1 - 2.1e-14 53.2 0.0 5.2e-14 51.9 0.0 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain ABC2_membrane PF01061.24 ADV22765.1 - 5.1e-34 117.5 20.4 8.2e-34 116.9 20.4 1.3 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 ADV22765.1 - 4e-28 98.6 0.0 6.2e-28 98.0 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ADV22765.1 - 5.5e-06 26.4 0.0 0.06 13.1 0.0 2.5 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ADV22765.1 - 0.0016 18.1 0.1 0.0037 17.0 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 ADV22765.1 - 0.0059 16.5 0.1 0.012 15.5 0.1 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 ADV22765.1 - 0.0081 16.6 0.0 0.014 15.8 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain SMC_N PF02463.19 ADV22765.1 - 0.014 14.9 0.0 0.19 11.2 0.0 2.0 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain NACHT PF05729.12 ADV22765.1 - 0.023 14.6 0.0 0.096 12.6 0.0 2.0 2 0 0 2 2 2 0 NACHT domain AAA_25 PF13481.6 ADV22765.1 - 0.034 13.7 0.1 0.13 11.8 0.1 1.8 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 ADV22765.1 - 0.088 13.0 0.0 0.17 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 ADV22765.1 - 0.12 13.0 0.0 0.22 12.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 ADV22765.1 - 0.17 12.0 0.1 0.33 11.1 0.1 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_28 PF13521.6 ADV22765.1 - 0.26 11.5 0.2 0.45 10.7 0.2 1.3 1 0 0 1 1 1 0 AAA domain ABC2_membrane_3 PF12698.7 ADV22765.1 - 1.5 7.8 30.7 0.019 14.1 23.0 1.7 2 0 0 2 2 1 0 ABC-2 family transporter protein EGF_2 PF07974.13 ADV22765.1 - 2.4 8.6 32.4 0.13 12.7 14.2 3.7 3 0 0 3 3 3 0 EGF-like domain hEGF PF12661.7 ADV22765.1 - 4.9 7.9 23.7 0.83 10.4 10.1 4.4 3 0 0 3 3 3 0 Human growth factor-like EGF HMG-CoA_red PF00368.18 ADV22766.1 - 1.1e-142 475.5 3.1 1.4e-142 475.0 3.1 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase Sterol-sensing PF12349.8 ADV22766.1 - 3e-11 43.4 7.2 7.7e-08 32.3 0.5 2.8 3 0 0 3 3 3 2 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.18 ADV22766.1 - 7.6e-05 21.0 2.1 0.0011 17.2 2.0 2.4 2 1 0 2 2 2 1 Patched family HPIH PF13323.6 ADV22766.1 - 0.0059 16.5 0.3 0.0059 16.5 0.3 1.8 2 0 0 2 2 2 1 N-terminal domain with HPIH motif Ribosomal_L1 PF00687.21 ADV22767.1 - 1.9e-50 171.4 0.6 3.1e-50 170.8 0.0 1.7 2 1 0 2 2 2 1 Ribosomal protein L1p/L10e family MFS_1 PF07690.16 ADV22768.1 - 8.8e-21 74.2 63.7 2.9e-19 69.2 41.0 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily CBF PF03914.17 ADV22769.1 - 2.8e-31 108.8 1.7 4.1e-31 108.3 0.5 1.9 2 0 0 2 2 2 1 CBF/Mak21 family Arm PF00514.23 ADV22769.1 - 0.11 12.6 0.0 0.27 11.4 0.0 1.6 1 0 0 1 1 1 0 Armadillo/beta-catenin-like repeat EMC1_C PF07774.13 ADV22770.1 - 4.5e-67 225.9 0.0 8.5e-67 224.9 0.0 1.5 1 0 0 1 1 1 1 ER membrane protein complex subunit 1, C-terminal PQQ PF01011.21 ADV22770.1 - 1.4e-14 53.2 0.1 0.013 15.4 0.0 6.0 6 0 0 6 6 6 4 PQQ enzyme repeat PQQ_2 PF13360.6 ADV22770.1 - 1.9e-14 53.8 2.1 2.9e-06 27.1 0.0 4.0 4 1 0 4 4 4 3 PQQ-like domain ANAPC4_WD40 PF12894.7 ADV22770.1 - 0.0019 18.4 0.2 1.8 8.9 0.0 4.1 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Ring_hydroxyl_B PF00866.18 ADV22771.1 - 0.013 15.5 0.6 0.03 14.4 0.6 1.5 1 0 0 1 1 1 0 Ring hydroxylating beta subunit NUP214 PF16755.5 ADV22771.1 - 0.092 12.0 0.0 0.16 11.1 0.0 1.3 1 0 0 1 1 1 0 Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 DUF1664 PF07889.12 ADV22771.1 - 1.8 8.6 4.1 4.5 7.3 0.4 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) AMPK1_CBM PF16561.5 ADV22772.1 - 3.9e-30 103.9 0.2 6.8e-30 103.1 0.2 1.3 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase AMPKBI PF04739.15 ADV22772.1 - 2.4e-22 79.0 0.0 2.4e-22 79.0 0.0 1.9 2 0 0 2 2 2 1 5'-AMP-activated protein kinase beta subunit, interaction domain PapC_N PF13954.6 ADV22772.1 - 0.028 14.5 0.0 0.063 13.3 0.0 1.6 1 0 0 1 1 1 0 PapC N-terminal domain FAD_binding_1 PF00667.20 ADV22773.1 - 8e-35 120.4 0.0 1.9e-34 119.2 0.0 1.6 2 0 0 2 2 2 1 FAD binding domain Flavodoxin_1 PF00258.25 ADV22773.1 - 6.1e-29 101.1 0.0 1.9e-28 99.5 0.0 1.9 2 0 0 2 2 2 1 Flavodoxin NAD_binding_1 PF00175.21 ADV22773.1 - 1.9e-09 38.2 0.0 3.4e-09 37.3 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Flavodoxin_5 PF12724.7 ADV22773.1 - 0.17 12.2 0.0 0.35 11.1 0.0 1.5 1 0 0 1 1 1 0 Flavodoxin domain Abhydrolase_3 PF07859.13 ADV22774.1 - 1.9e-47 161.9 0.0 3e-47 161.2 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 ADV22774.1 - 6.1e-10 38.5 0.0 2.9e-08 33.0 0.0 2.3 2 1 0 2 2 2 2 Steryl acetyl hydrolase MFS_1 PF07690.16 ADV22775.1 - 4.4e-27 94.9 31.4 6e-27 94.5 31.4 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily HEAT_2 PF13646.6 ADV22776.1 - 2.8e-09 37.2 3.3 0.0057 17.0 0.0 6.1 4 1 1 5 5 5 3 HEAT repeats HEAT PF02985.22 ADV22776.1 - 9.5e-09 34.8 13.9 0.1 12.9 0.0 8.6 10 0 0 10 10 10 3 HEAT repeat Adaptin_N PF01602.20 ADV22776.1 - 6.9e-05 21.6 0.0 0.041 12.4 0.0 3.2 3 0 0 3 3 3 2 Adaptin N terminal region HEAT_EZ PF13513.6 ADV22776.1 - 0.001 19.6 15.5 3.1 8.4 0.3 7.8 6 1 2 8 8 8 1 HEAT-like repeat CLASP_N PF12348.8 ADV22776.1 - 0.0016 18.1 1.9 0.15 11.6 0.1 4.0 4 1 1 5 5 5 1 CLASP N terminal Cnd1 PF12717.7 ADV22776.1 - 0.015 15.3 0.0 27 4.8 0.0 4.3 4 0 0 4 4 4 0 non-SMC mitotic condensation complex subunit 1 DUF89 PF01937.19 ADV22777.1 - 1.7e-123 412.1 0.1 1.9e-123 411.9 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF89 Methyltransf_16 PF10294.9 ADV22778.1 - 2.7e-17 63.1 0.0 6.8e-17 61.7 0.0 1.6 1 1 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 ADV22778.1 - 6.5e-05 22.8 0.0 9.8e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain TehB PF03848.14 ADV22778.1 - 0.00079 18.9 0.0 0.02 14.3 0.0 2.2 1 1 1 2 2 2 1 Tellurite resistance protein TehB Methyltransf_25 PF13649.6 ADV22778.1 - 0.0018 19.0 0.1 0.011 16.5 0.1 2.2 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ADV22778.1 - 0.0034 17.0 0.0 0.0056 16.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.19 ADV22778.1 - 0.0037 17.1 0.0 0.0065 16.2 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_11 PF08241.12 ADV22778.1 - 0.0037 17.9 0.0 0.014 16.0 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ADV22778.1 - 0.042 14.6 0.2 0.18 12.5 0.2 2.1 1 1 0 1 1 1 0 Methyltransferase domain PrmA PF06325.13 ADV22778.1 - 0.097 12.0 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) SH3_9 PF14604.6 ADV22779.1 - 2.5e-07 30.4 0.1 3.9e-07 29.8 0.1 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ADV22779.1 - 6.6e-05 22.4 0.0 0.00011 21.7 0.0 1.3 1 0 0 1 1 1 1 SH3 domain Amnionless PF14828.6 ADV22779.1 - 0.00044 19.2 0.1 0.00044 19.2 0.1 1.5 1 1 0 2 2 2 1 Amnionless Glycophorin_A PF01102.18 ADV22779.1 - 0.0011 19.2 6.9 0.0011 19.2 6.9 3.3 1 1 1 2 2 2 1 Glycophorin A TMEM154 PF15102.6 ADV22779.1 - 0.0024 17.8 2.8 0.0024 17.8 2.8 3.1 1 1 1 2 2 2 1 TMEM154 protein family RIFIN PF02009.16 ADV22779.1 - 0.93 9.3 7.9 1.7 8.5 7.9 1.4 1 0 0 1 1 1 0 Rifin Zip PF02535.22 ADV22780.1 - 0.25 10.5 0.7 1.1 8.4 0.0 2.4 3 0 0 3 3 3 0 ZIP Zinc transporter U79_P34 PF03064.16 ADV22780.1 - 2.8 7.2 8.5 0.073 12.4 1.4 2.0 2 0 0 2 2 2 0 HSV U79 / HCMV P34 DNA_pol_phi PF04931.13 ADV22780.1 - 3.7 5.5 5.5 8 4.4 5.5 1.5 1 0 0 1 1 1 0 DNA polymerase phi Velvet PF11754.8 ADV22785.1 - 3.1e-49 168.2 2.9 3.4e-34 118.9 0.5 4.6 2 2 1 3 3 3 2 Velvet factor POT1 PF02765.17 ADV22786.1 - 1.9e-05 24.5 0.0 5.9e-05 22.9 0.0 1.8 2 0 0 2 2 2 1 Telomeric single stranded DNA binding POT1/CDC13 POT1PC PF16686.5 ADV22786.1 - 0.0048 16.8 0.1 0.037 13.9 0.0 2.1 2 0 0 2 2 2 1 ssDNA-binding domain of telomere protection protein CDC24_OB3 PF17244.2 ADV22786.1 - 0.075 12.7 0.1 5.4 6.7 0.0 2.3 2 0 0 2 2 2 0 Cell division control protein 24, OB domain 3 Sec63 PF02889.16 ADV22788.1 - 1.7e-162 538.7 0.1 1.7e-90 302.6 0.0 2.3 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 ADV22788.1 - 2.2e-50 170.9 1.4 2.1e-28 99.3 0.3 3.0 3 0 0 3 3 3 2 DEAD/DEAH box helicase Helicase_PWI PF18149.1 ADV22788.1 - 5.9e-35 119.8 0.0 2.4e-34 117.8 0.0 2.2 1 0 0 1 1 1 1 N-terminal helicase PWI domain ResIII PF04851.15 ADV22788.1 - 6.5e-20 71.8 0.0 1.4e-13 51.2 0.0 2.6 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 ADV22788.1 - 2.6e-14 53.5 0.0 1.4e-07 31.8 0.0 4.6 4 2 0 4 4 4 2 Helicase conserved C-terminal domain AAA_22 PF13401.6 ADV22788.1 - 1.3e-06 28.7 0.0 0.039 14.2 0.0 3.3 3 0 0 3 3 3 2 AAA domain Helicase_C_2 PF13307.6 ADV22788.1 - 0.0061 16.7 0.1 8.4 6.5 0.0 3.6 3 1 0 3 3 3 1 Helicase C-terminal domain PhoH PF02562.16 ADV22788.1 - 0.031 13.7 0.0 0.31 10.5 0.0 2.4 2 0 0 2 2 2 0 PhoH-like protein HTH_39 PF14090.6 ADV22788.1 - 0.12 12.2 0.0 0.45 10.3 0.0 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain BUD22 PF09073.10 ADV22788.1 - 1.2 8.4 14.9 2.6 7.3 14.9 1.4 1 0 0 1 1 1 0 BUD22 Pes-10 PF07149.11 ADV22788.1 - 2.8 6.9 12.5 5.9 5.9 12.5 1.4 1 0 0 1 1 1 0 Pes-10 AAA_23 PF13476.6 ADV22788.1 - 4.6 7.7 8.1 24 5.3 0.0 3.6 3 0 0 3 3 3 0 AAA domain zf-primase PF09329.11 ADV22789.1 - 1.7e-18 66.2 2.6 3.5e-18 65.1 2.6 1.6 1 0 0 1 1 1 1 Primase zinc finger HCV_NS5a_C PF12941.7 ADV22789.1 - 0.018 14.9 2.5 0.036 13.9 2.5 1.5 1 0 0 1 1 1 0 HCV NS5a protein C-terminal region PHD PF00628.29 ADV22790.1 - 1.7e-08 34.2 4.9 2.9e-08 33.5 4.9 1.4 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 ADV22790.1 - 0.15 11.7 0.8 0.26 10.8 0.8 1.4 1 0 0 1 1 1 0 PHD-finger UQ_con PF00179.26 ADV22791.1 - 1.7e-40 137.9 0.0 2.9e-40 137.1 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 ADV22791.1 - 0.02 14.6 0.0 0.034 13.9 0.0 1.4 1 1 0 1 1 1 0 Prokaryotic E2 family B CBM-like PF14683.6 ADV22792.1 - 3.1e-32 111.7 0.7 5.3e-32 111.0 0.1 1.8 2 0 0 2 2 2 1 Polysaccharide lyase family 4, domain III fn3_3 PF14686.6 ADV22792.1 - 2.1e-21 75.5 0.6 2.1e-21 75.5 0.6 2.5 2 1 1 3 3 3 1 Polysaccharide lyase family 4, domain II CarboxypepD_reg PF13620.6 ADV22792.1 - 0.016 15.5 0.2 0.065 13.5 0.2 2.0 1 0 0 1 1 1 0 Carboxypeptidase regulatory-like domain Y_phosphatase2 PF03162.13 ADV22793.1 - 6.7e-35 120.1 0.0 7.7e-35 119.9 0.0 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family MFS_1 PF07690.16 ADV22794.1 - 6.6e-13 48.3 36.6 1.8e-12 46.8 34.5 2.7 1 1 0 1 1 1 1 Major Facilitator Superfamily Nodulin-like PF06813.13 ADV22794.1 - 2.3e-11 43.7 3.2 2.3e-11 43.7 3.2 2.1 2 0 0 2 2 2 1 Nodulin-like Asp-B-Hydro_N PF05279.11 ADV22795.1 - 9.7 6.2 16.5 12 5.8 16.5 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region E1_dh PF00676.20 ADV22797.1 - 1.3e-115 385.5 0.1 1.5e-115 385.3 0.1 1.0 1 0 0 1 1 1 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.21 ADV22797.1 - 9e-05 22.3 1.7 0.00026 20.8 0.4 2.1 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DXP_synthase_N PF13292.6 ADV22797.1 - 9.1e-05 21.8 0.0 0.00015 21.0 0.0 1.3 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase DUF4452 PF14618.6 ADV22798.1 - 0.11 12.4 3.1 0.14 12.0 3.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4452) MFS_1 PF07690.16 ADV22799.1 - 1.7e-23 83.1 45.1 7.8e-15 54.6 20.3 2.7 1 1 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ADV22799.1 - 5.8e-18 65.0 16.9 8.2e-17 61.2 0.5 2.3 2 0 0 2 2 2 2 Sugar (and other) transporter Pkinase PF00069.25 ADV22801.1 - 3.3e-52 177.5 0.0 5e-52 176.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV22801.1 - 6e-28 97.8 0.0 7.8e-28 97.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ADV22801.1 - 0.00052 19.4 0.0 0.0011 18.4 0.0 1.5 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 ADV22801.1 - 0.034 14.1 0.0 0.052 13.5 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family FTA2 PF13095.6 ADV22801.1 - 0.061 12.9 0.0 0.086 12.5 0.0 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 ADV22801.1 - 0.068 12.5 0.0 0.1 11.9 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family JAB PF01398.21 ADV22804.1 - 3.2e-15 56.1 0.1 4.9e-15 55.5 0.1 1.2 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 ADV22804.1 - 1.1e-08 35.5 0.0 2e-08 34.6 0.0 1.5 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function UPF0172 PF03665.13 ADV22804.1 - 0.0032 17.5 0.0 0.0048 17.0 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0172) LIM PF00412.22 ADV22805.1 - 7e-12 45.4 6.2 9.8e-12 44.9 6.2 1.2 1 0 0 1 1 1 1 LIM domain NinD PF17466.2 ADV22805.1 - 0.035 14.2 0.5 0.07 13.2 0.5 1.5 1 0 0 1 1 1 0 Family of unknown function DZR PF12773.7 ADV22805.1 - 0.11 12.5 5.6 1.4 9.0 5.6 2.2 1 1 0 1 1 1 0 Double zinc ribbon Zn-ribbon_8 PF09723.10 ADV22805.1 - 9.2 6.5 7.7 2.9 8.1 3.4 2.0 2 0 0 2 2 2 0 Zinc ribbon domain Pkinase PF00069.25 ADV22806.1 - 3.3e-74 249.6 0.1 9.9e-74 248.0 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV22806.1 - 4.2e-39 134.4 0.0 6.6e-39 133.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase AdenylateSensor PF16579.5 ADV22806.1 - 9.6e-16 58.3 0.4 7.4e-09 36.1 0.0 3.2 2 1 0 3 3 3 2 Adenylate sensor of SNF1-like protein kinase Kinase-like PF14531.6 ADV22806.1 - 1.9e-11 43.8 0.0 3.1e-11 43.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like UBA_2 PF08587.11 ADV22806.1 - 0.013 15.6 0.0 0.033 14.3 0.0 1.7 1 0 0 1 1 1 0 Ubiquitin associated domain (UBA) Kdo PF06293.14 ADV22806.1 - 0.02 14.2 0.9 0.061 12.7 0.9 1.7 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ADV22806.1 - 0.077 11.9 0.1 0.13 11.2 0.1 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Carn_acyltransf PF00755.20 ADV22807.1 - 6.2e-207 688.8 0.0 2.7e-206 686.8 0.0 1.7 1 1 0 1 1 1 1 Choline/Carnitine o-acyltransferase mRNA_triPase PF02940.15 ADV22808.1 - 1.2e-51 175.5 0.0 1.6e-51 175.2 0.0 1.1 1 0 0 1 1 1 1 mRNA capping enzyme, beta chain RCC1 PF00415.18 ADV22810.1 - 4e-57 190.7 11.4 7.5e-10 39.3 0.1 8.5 8 0 0 8 8 8 8 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ADV22810.1 - 1.8e-38 129.5 37.7 4.8e-08 32.6 0.2 8.0 8 0 0 8 8 8 7 Regulator of chromosome condensation (RCC1) repeat Hira PF07569.11 ADV22810.1 - 0.1 12.3 0.0 1.1 8.9 0.0 2.6 3 0 0 3 3 3 0 TUP1-like enhancer of split HMG_box PF00505.19 ADV22811.1 - 8.4e-24 83.8 3.3 1.4e-23 83.1 3.3 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ADV22811.1 - 3.4e-22 78.8 4.0 6e-22 78.0 4.0 1.4 1 0 0 1 1 1 1 HMG-box domain YABBY PF04690.13 ADV22811.1 - 3.1e-05 24.6 1.5 3.1e-05 24.6 1.5 1.8 1 1 1 2 2 2 1 YABBY protein CHDNT PF08073.12 ADV22811.1 - 0.0016 18.4 0.0 0.0026 17.7 0.0 1.3 1 0 0 1 1 1 1 CHDNT (NUC034) domain HMG_box_5 PF14887.6 ADV22811.1 - 0.0035 17.3 5.0 0.0035 17.3 5.0 1.4 1 1 0 1 1 1 1 HMG (high mobility group) box 5 CDP-OH_P_transf PF01066.21 ADV22812.1 - 3.1e-16 59.9 0.6 3.1e-16 59.9 0.6 2.8 3 1 0 3 3 3 1 CDP-alcohol phosphatidyltransferase COG7 PF10191.9 ADV22813.1 - 2.6e-43 148.3 0.0 4e-24 84.9 0.0 3.4 3 1 0 3 3 3 3 Golgi complex component 7 (COG7) Aa_trans PF01490.18 ADV22814.1 - 2.3e-21 76.0 39.9 6e-19 68.0 39.9 2.0 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein TMEM169 PF15052.6 ADV22814.1 - 6.1 7.0 20.3 0.37 10.9 3.8 3.4 3 0 0 3 3 3 0 TMEM169 protein family ILVD_EDD PF00920.21 ADV22815.1 - 9.3e-152 506.2 0.0 1.1e-151 506.0 0.0 1.0 1 0 0 1 1 1 1 Dehydratase family MFS_1 PF07690.16 ADV22816.1 - 3.1e-15 56.0 29.0 3.1e-15 56.0 29.0 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily CDP-OH_P_tran_2 PF08009.11 ADV22816.1 - 0.052 13.4 0.4 0.052 13.4 0.4 3.4 3 1 0 3 3 3 0 CDP-alcohol phosphatidyltransferase 2 MFS_1 PF07690.16 ADV22817.1 - 2.2e-16 59.7 55.4 7.6e-16 58.0 51.5 2.7 1 1 2 3 3 3 3 Major Facilitator Superfamily MFS_1 PF07690.16 ADV22818.1 - 1.2e-16 60.6 58.6 1.9e-15 56.7 33.3 3.0 1 1 2 3 3 3 3 Major Facilitator Superfamily DUF1449 PF07290.11 ADV22818.1 - 0.073 12.7 0.3 0.16 11.6 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1449) Adaptin_N PF01602.20 ADV22819.1 - 2.5e-12 46.1 0.1 6.5e-12 44.8 0.1 1.6 2 0 0 2 2 2 1 Adaptin N terminal region MMS19_N PF14500.6 ADV22819.1 - 0.026 14.1 0.0 0.048 13.2 0.0 1.4 1 0 0 1 1 1 0 Dos2-interacting transcription regulator of RNA-Pol-II GFO_IDH_MocA PF01408.22 ADV22820.1 - 3.1e-15 57.0 0.0 5.8e-15 56.2 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold AAA PF00004.29 ADV22822.1 - 3.2e-53 179.7 0.0 6.7e-41 139.8 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) CDC48_2 PF02933.17 ADV22822.1 - 5.8e-12 45.2 0.0 8.9e-10 38.2 0.0 2.6 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), domain 2 AAA_16 PF13191.6 ADV22822.1 - 1.4e-09 38.6 0.1 0.0031 17.9 0.0 2.8 2 1 0 2 2 2 2 AAA ATPase domain AAA_2 PF07724.14 ADV22822.1 - 2.7e-08 34.1 0.2 8e-06 26.1 0.1 2.6 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_lid_3 PF17862.1 ADV22822.1 - 3.4e-08 33.2 0.1 7.2e-08 32.1 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 ADV22822.1 - 6.7e-08 32.9 0.3 0.0031 17.8 0.0 3.0 2 2 0 2 2 2 2 AAA domain TIP49 PF06068.13 ADV22822.1 - 1.1e-07 31.4 0.1 0.0028 16.9 0.0 2.2 2 0 0 2 2 2 2 TIP49 P-loop domain RuvB_N PF05496.12 ADV22822.1 - 1.7e-07 31.1 0.2 0.017 14.8 0.1 2.8 2 1 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 ADV22822.1 - 4.5e-07 30.0 0.1 0.0015 18.5 0.0 3.0 3 0 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 ADV22822.1 - 1e-06 28.6 0.1 0.022 14.5 0.0 2.7 2 1 0 2 2 2 2 AAA domain TsaE PF02367.17 ADV22822.1 - 4.1e-06 26.8 0.0 0.13 12.2 0.0 2.3 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE Mg_chelatase PF01078.21 ADV22822.1 - 1.1e-05 25.0 0.2 0.0064 15.9 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 ADV22822.1 - 1.3e-05 25.1 0.0 0.088 12.5 0.0 2.6 2 0 0 2 2 2 2 IstB-like ATP binding protein Sigma54_activat PF00158.26 ADV22822.1 - 2e-05 24.4 0.0 0.095 12.4 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_33 PF13671.6 ADV22822.1 - 2e-05 24.8 0.0 0.15 12.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 ADV22822.1 - 2.2e-05 24.8 0.0 0.061 13.7 0.0 2.6 2 0 0 2 2 2 2 RNA helicase ABC_tran PF00005.27 ADV22822.1 - 4.8e-05 23.9 0.9 0.16 12.5 0.1 2.5 2 0 0 2 2 2 2 ABC transporter AAA_7 PF12775.7 ADV22822.1 - 8.3e-05 22.2 0.1 0.035 13.6 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_18 PF13238.6 ADV22822.1 - 8.9e-05 23.0 0.0 0.03 14.9 0.0 2.9 2 1 1 3 3 3 1 AAA domain NACHT PF05729.12 ADV22822.1 - 0.00016 21.6 1.1 0.23 11.4 0.1 3.0 3 1 0 3 3 2 2 NACHT domain ATPase PF06745.13 ADV22822.1 - 0.00066 19.1 1.0 0.0092 15.3 0.1 2.4 2 0 0 2 2 2 1 KaiC AAA_30 PF13604.6 ADV22822.1 - 0.00095 18.9 0.0 0.37 10.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain PhoH PF02562.16 ADV22822.1 - 0.0014 18.1 0.0 1.8 8.0 0.0 2.4 2 0 0 2 2 2 2 PhoH-like protein ATPase_2 PF01637.18 ADV22822.1 - 0.0015 18.5 0.4 12 5.7 0.0 3.3 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea NB-ARC PF00931.22 ADV22822.1 - 0.0016 17.6 0.2 1.3 8.1 0.0 2.4 2 0 0 2 2 2 2 NB-ARC domain AAA_28 PF13521.6 ADV22822.1 - 0.0024 18.1 0.0 0.82 9.9 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 ADV22822.1 - 0.0038 16.8 5.6 2.1 7.9 0.1 4.1 3 1 1 4 4 4 1 AAA domain AAA_14 PF13173.6 ADV22822.1 - 0.0059 16.6 0.0 0.89 9.6 0.0 2.6 2 0 0 2 2 2 1 AAA domain TniB PF05621.11 ADV22822.1 - 0.0065 15.9 0.1 5.5 6.4 0.0 2.9 2 1 0 2 2 2 0 Bacterial TniB protein Parvo_NS1 PF01057.17 ADV22822.1 - 0.011 14.9 0.0 0.9 8.6 0.0 2.2 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 ResIII PF04851.15 ADV22822.1 - 0.012 15.6 0.1 2.2 8.3 0.1 2.6 2 1 1 3 3 3 0 Type III restriction enzyme, res subunit AAA_11 PF13086.6 ADV22822.1 - 0.019 14.8 0.1 0.38 10.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_3 PF07726.11 ADV22822.1 - 0.025 14.4 0.0 0.39 10.6 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DAP3 PF10236.9 ADV22822.1 - 0.041 13.1 0.1 29 3.7 0.0 3.1 3 0 0 3 3 3 0 Mitochondrial ribosomal death-associated protein 3 AAA_17 PF13207.6 ADV22822.1 - 0.047 14.1 0.2 10 6.6 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 ADV22822.1 - 0.054 13.2 0.1 3.5 7.5 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain CPT PF07931.12 ADV22822.1 - 0.071 12.9 0.1 0.95 9.3 0.0 2.3 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein Zeta_toxin PF06414.12 ADV22822.1 - 0.073 12.3 0.1 2.8 7.2 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin AAA_19 PF13245.6 ADV22822.1 - 0.091 13.1 0.8 0.79 10.0 0.1 2.4 2 1 0 2 2 2 0 AAA domain DUF2075 PF09848.9 ADV22822.1 - 0.092 12.0 0.7 3.5 6.8 0.1 2.6 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) Rad17 PF03215.15 ADV22822.1 - 0.12 12.3 0.0 12 5.7 0.0 2.9 3 0 0 3 3 3 0 Rad17 P-loop domain AFG1_ATPase PF03969.16 ADV22822.1 - 0.13 11.1 0.0 2.9 6.7 0.0 2.1 2 0 0 2 2 2 0 AFG1-like ATPase Cytidylate_kin PF02224.18 ADV22822.1 - 0.16 11.7 0.1 10 5.8 0.1 2.4 2 0 0 2 2 2 0 Cytidylate kinase Amidohydro_3 PF07969.11 ADV22823.1 - 3.4e-83 280.7 0.0 4.5e-83 280.3 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_1 PF01979.20 ADV22823.1 - 6.6e-09 35.5 0.0 3.7e-08 33.1 0.0 2.0 2 0 0 2 2 2 1 Amidohydrolase family Peptidase_M20 PF01546.28 ADV22824.1 - 2.7e-30 105.6 0.0 4e-30 105.1 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 WD40 PF00400.32 ADV22824.1 - 1.9e-09 38.0 5.7 0.13 13.1 0.0 5.6 5 0 0 5 5 5 3 WD domain, G-beta repeat M20_dimer PF07687.14 ADV22824.1 - 5.9e-09 35.8 0.0 1.1e-08 35.0 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain ANAPC4_WD40 PF12894.7 ADV22824.1 - 0.0005 20.3 0.0 1 9.7 0.0 3.3 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 ADV22824.1 - 0.02 15.4 5.9 20 5.8 0.0 4.9 5 0 0 5 5 5 0 PQQ-like domain Ras PF00071.22 ADV22825.1 - 7.2e-51 172.0 0.0 8.6e-51 171.7 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ADV22825.1 - 1e-24 87.1 0.0 1.6e-24 86.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ADV22825.1 - 4.5e-07 29.5 0.0 6.5e-07 29.0 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ADV22825.1 - 0.00056 20.0 0.0 0.0015 18.6 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ADV22825.1 - 0.00061 19.4 0.0 0.0076 15.8 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ADV22825.1 - 0.0041 17.0 0.0 1.5 8.7 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase SRPRB PF09439.10 ADV22825.1 - 0.0076 15.7 0.0 0.011 15.2 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit TniB PF05621.11 ADV22825.1 - 0.032 13.6 0.0 0.053 12.9 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein AAA_16 PF13191.6 ADV22825.1 - 0.05 14.0 0.0 0.14 12.6 0.0 1.8 1 1 1 2 2 2 0 AAA ATPase domain PduV-EutP PF10662.9 ADV22825.1 - 0.13 12.0 0.0 19 5.0 0.0 2.6 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation DNA_pol_B PF00136.21 ADV22826.1 - 1.7e-115 386.4 0.0 2.3e-115 385.9 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase family B zf-DNA_Pol PF08996.10 ADV22826.1 - 4.7e-59 199.2 0.0 8.2e-59 198.5 0.0 1.4 1 0 0 1 1 1 1 DNA Polymerase alpha zinc finger DNA_pol_B_exo1 PF03104.19 ADV22826.1 - 1e-32 113.6 0.0 2.2e-32 112.5 0.0 1.6 2 0 0 2 2 2 1 DNA polymerase family B, exonuclease domain DNA_pol_alpha_N PF12254.8 ADV22826.1 - 8.3e-20 70.6 3.3 8.3e-20 70.6 3.3 2.4 2 0 0 2 2 2 1 DNA polymerase alpha subunit p180 N terminal DNA_pol_B_2 PF03175.13 ADV22826.1 - 0.051 12.4 0.1 0.17 10.7 0.0 1.8 2 0 0 2 2 2 0 DNA polymerase type B, organellar and viral YL1 PF05764.13 ADV22826.1 - 0.43 10.7 25.5 0.012 15.7 14.9 2.4 1 1 0 2 2 2 0 YL1 nuclear protein Amelogenin PF02948.15 ADV22827.1 - 3.8 8.1 12.3 1.1 9.9 4.0 2.7 1 1 1 2 2 2 0 Amelogenin DUF1977 PF09320.11 ADV22828.1 - 2.1e-24 85.8 0.5 3.8e-24 84.9 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF1977) DnaJ PF00226.31 ADV22828.1 - 1.2e-22 79.8 0.2 2.1e-22 79.0 0.2 1.4 1 0 0 1 1 1 1 DnaJ domain SSP160 PF06933.11 ADV22828.1 - 0.31 9.2 2.8 0.41 8.8 2.8 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 GCK PF07802.11 ADV22828.1 - 0.37 11.3 2.8 0.76 10.2 2.8 1.4 1 0 0 1 1 1 0 GCK domain GDPD PF03009.17 ADV22829.1 - 2.2e-32 112.8 0.0 3.5e-32 112.1 0.0 1.3 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family GDPD_2 PF13653.6 ADV22829.1 - 0.00013 22.3 0.0 0.0061 17.0 0.0 2.6 2 0 0 2 2 2 1 Glycerophosphoryl diester phosphodiesterase family RED_N PF07808.13 ADV22831.1 - 1.3e-13 51.1 17.7 1.3e-13 51.1 17.7 2.1 2 1 0 2 2 2 1 RED-like protein N-terminal region EF_assoc_2 PF08356.12 ADV22832.1 - 9.3e-31 105.7 0.0 6.8e-30 102.9 0.0 2.3 2 0 0 2 2 2 1 EF hand associated Ras PF00071.22 ADV22832.1 - 5.8e-29 100.8 0.0 1.8e-21 76.4 0.0 2.4 2 0 0 2 2 2 2 Ras family EF_assoc_1 PF08355.12 ADV22832.1 - 4.5e-20 71.0 0.1 1e-19 69.8 0.1 1.7 1 0 0 1 1 1 1 EF hand associated Roc PF08477.13 ADV22832.1 - 3.9e-19 69.0 0.0 5.5e-11 42.7 0.0 2.4 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ADV22832.1 - 4.4e-11 42.5 0.0 1.7e-06 27.6 0.0 2.7 2 1 0 2 2 2 2 ADP-ribosylation factor family EF-hand_6 PF13405.6 ADV22832.1 - 8.2e-09 34.7 0.2 0.0012 18.6 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 ADV22832.1 - 1.8e-08 33.3 0.8 0.0018 17.7 0.2 2.5 2 0 0 2 2 2 2 EF hand MMR_HSR1 PF01926.23 ADV22832.1 - 6.2e-08 32.7 0.1 0.0081 16.2 0.0 2.7 2 1 0 2 2 2 2 50S ribosome-binding GTPase EF-hand_7 PF13499.6 ADV22832.1 - 2.4e-07 31.1 0.6 0.013 15.9 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain pair AAA_22 PF13401.6 ADV22832.1 - 2.8e-06 27.7 0.1 0.17 12.2 0.1 3.3 3 2 0 3 3 2 2 AAA domain RsgA_GTPase PF03193.16 ADV22832.1 - 1.5e-05 25.0 0.0 0.14 12.0 0.0 3.6 4 0 0 4 4 3 1 RsgA GTPase EF-hand_5 PF13202.6 ADV22832.1 - 2.1e-05 23.8 2.2 0.012 15.1 0.5 2.5 2 0 0 2 2 2 2 EF hand AAA_16 PF13191.6 ADV22832.1 - 3.2e-05 24.4 0.0 0.32 11.3 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain SRPRB PF09439.10 ADV22832.1 - 4.2e-05 23.1 0.0 0.0061 16.0 0.0 2.4 2 1 0 2 2 2 1 Signal recognition particle receptor beta subunit ABC_tran PF00005.27 ADV22832.1 - 0.00016 22.2 0.3 0.67 10.5 0.0 2.5 2 1 0 2 2 2 2 ABC transporter Dynamin_N PF00350.23 ADV22832.1 - 0.00082 19.5 3.6 0.76 9.8 0.1 3.2 2 1 1 3 3 3 1 Dynamin family NACHT PF05729.12 ADV22832.1 - 0.00082 19.3 0.0 0.5 10.3 0.0 2.5 2 0 0 2 2 2 1 NACHT domain AIG1 PF04548.16 ADV22832.1 - 0.001 18.4 0.9 0.0014 18.0 0.1 1.6 2 0 0 2 2 1 1 AIG1 family AAA_18 PF13238.6 ADV22832.1 - 0.0016 19.0 0.0 0.28 11.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain FtsK_SpoIIIE PF01580.18 ADV22832.1 - 0.0028 17.0 0.0 0.95 8.8 0.0 2.3 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_29 PF13555.6 ADV22832.1 - 0.0045 16.7 0.0 3.3 7.5 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_7 PF12775.7 ADV22832.1 - 0.0048 16.4 0.0 0.55 9.7 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_5 PF07728.14 ADV22832.1 - 0.0098 15.9 0.0 0.57 10.2 0.0 2.7 3 0 0 3 3 2 1 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 ADV22832.1 - 0.014 15.8 0.0 2.4 8.6 0.0 2.7 2 0 0 2 2 2 0 RNA helicase Pox_A32 PF04665.12 ADV22832.1 - 0.014 14.9 0.1 2.8 7.4 0.0 2.7 3 0 0 3 3 3 0 Poxvirus A32 protein Viral_helicase1 PF01443.18 ADV22832.1 - 0.014 15.1 0.3 0.76 9.5 0.0 2.6 2 1 1 3 3 3 0 Viral (Superfamily 1) RNA helicase SPARC_Ca_bdg PF10591.9 ADV22832.1 - 0.014 15.7 0.2 5.1 7.5 0.0 2.3 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region AAA_24 PF13479.6 ADV22832.1 - 0.017 14.8 0.2 2.3 7.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 ADV22832.1 - 0.019 15.2 0.3 7.1 6.8 0.1 2.5 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.13 ADV22832.1 - 0.026 13.7 0.0 1.2 8.3 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA PF00004.29 ADV22832.1 - 0.028 14.8 0.0 3.2 8.2 0.0 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Septin PF00735.18 ADV22832.1 - 0.039 13.2 0.1 1.1 8.5 0.0 2.3 2 0 0 2 2 2 0 Septin G-alpha PF00503.20 ADV22832.1 - 0.046 12.9 0.0 1 8.5 0.0 2.5 3 0 0 3 3 3 0 G-protein alpha subunit ATPase_2 PF01637.18 ADV22832.1 - 0.059 13.3 0.0 0.46 10.4 0.0 2.2 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea DUF87 PF01935.17 ADV22832.1 - 0.065 13.3 0.4 1.1 9.3 0.1 2.2 2 0 0 2 2 2 0 Helicase HerA, central domain TniB PF05621.11 ADV22832.1 - 0.093 12.1 0.0 13 5.1 0.0 2.3 2 0 0 2 2 2 0 Bacterial TniB protein ATP_bind_1 PF03029.17 ADV22832.1 - 0.1 12.3 0.4 33 4.1 0.1 3.3 4 0 0 4 4 4 0 Conserved hypothetical ATP binding protein cobW PF02492.19 ADV22832.1 - 0.2 11.2 0.0 3.6 7.1 0.1 2.6 3 0 0 3 3 2 0 CobW/HypB/UreG, nucleotide-binding domain NOG1 PF06858.14 ADV22832.1 - 0.2 11.5 0.3 8.5 6.2 0.1 2.6 2 0 0 2 2 2 0 Nucleolar GTP-binding protein 1 (NOG1) DUF2075 PF09848.9 ADV22832.1 - 0.21 10.8 0.1 0.42 9.8 0.0 1.4 2 0 0 2 2 1 0 Uncharacterized conserved protein (DUF2075) TrwB_AAD_bind PF10412.9 ADV22832.1 - 0.22 10.4 0.0 11 4.9 0.0 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_23 PF13476.6 ADV22832.1 - 0.23 11.9 0.3 11 6.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain EF-hand_4 PF12763.7 ADV22832.1 - 0.35 10.8 1.1 4.8 7.2 0.0 2.9 3 0 0 3 3 3 0 Cytoskeletal-regulatory complex EF hand Yippee-Mis18 PF03226.14 ADV22833.1 - 7.4e-12 45.4 0.0 9.1e-12 45.1 0.0 1.1 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zinc_ribbon_12 PF11331.8 ADV22833.1 - 0.0014 18.3 1.3 0.016 15.0 0.2 2.1 2 0 0 2 2 2 1 Probable zinc-ribbon domain DUF4503 PF14951.6 ADV22833.1 - 0.095 11.1 0.0 0.1 11.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4503) MIOX PF05153.15 ADV22834.1 - 2.5e-128 426.9 1.9 2.5e-128 426.9 1.9 1.9 2 0 0 2 2 2 1 Myo-inositol oxygenase HD PF01966.22 ADV22834.1 - 0.0024 18.1 0.1 0.43 10.8 0.0 2.8 3 0 0 3 3 3 1 HD domain DUF1497 PF07384.11 ADV22834.1 - 0.13 12.7 0.7 0.37 11.2 0.7 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1497) Mito_carr PF00153.27 ADV22835.1 - 1.9e-11 43.7 0.0 0.027 14.4 0.1 4.8 4 1 0 4 4 4 3 Mitochondrial carrier protein HA2 PF04408.23 ADV22836.1 - 4.6e-25 88.0 1.5 5.5e-25 87.7 0.1 1.9 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 ADV22836.1 - 4.4e-20 71.8 0.0 2.1e-19 69.7 0.0 2.2 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 ADV22836.1 - 5.1e-10 39.7 0.0 1.2e-09 38.5 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 ADV22836.1 - 2.4e-08 33.9 0.1 4.4e-08 33.1 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase SRP54 PF00448.22 ADV22836.1 - 0.0042 16.7 0.2 0.018 14.6 0.2 1.9 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain DUF2075 PF09848.9 ADV22836.1 - 0.0068 15.7 0.0 0.011 15.1 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.6 ADV22836.1 - 0.015 15.6 0.0 0.069 13.4 0.0 2.1 1 1 0 1 1 1 0 AAA domain Flavi_DEAD PF07652.14 ADV22836.1 - 0.058 13.4 0.0 0.16 11.9 0.0 1.7 1 0 0 1 1 1 0 Flavivirus DEAD domain AAA_30 PF13604.6 ADV22836.1 - 0.085 12.6 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 ADV22836.1 - 0.1 11.7 0.0 0.19 10.8 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein DivIVA PF05103.13 ADV22837.1 - 0.00086 19.4 0.6 0.00086 19.4 0.6 7.3 3 1 4 8 8 8 1 DivIVA protein Spc7 PF08317.11 ADV22837.1 - 0.0048 15.8 12.2 0.0048 15.8 12.2 5.8 1 1 3 6 6 6 3 Spc7 kinetochore protein ZapD PF07072.11 ADV22837.1 - 0.35 10.6 28.8 0.087 12.6 1.1 4.6 4 1 0 4 4 4 0 Cell division protein Fib_alpha PF08702.10 ADV22837.1 - 3.2 7.9 35.6 0.18 12.0 4.9 4.2 4 1 0 4 4 4 0 Fibrinogen alpha/beta chain family SlyX PF04102.12 ADV22837.1 - 8.7 7.0 32.9 5.5 7.7 1.8 7.9 3 1 5 8 8 8 0 SlyX Not3 PF04065.15 ADV22838.1 - 1.2e-82 276.8 18.3 1.2e-82 276.8 18.3 2.8 3 0 0 3 3 3 1 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.18 ADV22838.1 - 7.7e-42 142.5 13.3 3.2e-41 140.5 13.3 2.1 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family Med15 PF09606.10 ADV22838.1 - 0.00089 18.1 14.5 0.00089 18.1 14.5 2.2 1 1 0 2 2 2 1 ARC105 or Med15 subunit of Mediator complex non-fungal Syntaxin_2 PF14523.6 ADV22838.1 - 0.012 16.0 1.7 0.012 16.0 1.7 2.8 3 0 0 3 3 3 0 Syntaxin-like protein SOG2 PF10428.9 ADV22838.1 - 3.4 6.8 29.5 5.8 6.0 29.5 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein zf-CCCH PF00642.24 ADV22839.1 - 0.11 12.5 0.6 0.29 11.1 0.6 1.8 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Peptidase_S10 PF00450.22 ADV22840.1 - 4.8e-107 359.0 0.0 5.9e-107 358.7 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase V4R PF02830.18 ADV22840.1 - 0.13 12.3 0.0 0.33 11.0 0.0 1.6 1 0 0 1 1 1 0 V4R domain FAT PF02259.23 ADV22841.1 - 2.5e-119 398.6 1.4 1.4e-118 396.1 0.0 2.3 2 0 0 2 2 2 1 FAT domain PI3_PI4_kinase PF00454.27 ADV22841.1 - 4e-65 220.1 0.1 7.4e-65 219.2 0.1 1.5 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase DUF3385 PF11865.8 ADV22841.1 - 2.4e-51 173.9 13.5 9.2e-50 168.7 0.5 6.4 6 1 1 7 7 7 1 Domain of unknown function (DUF3385) FRB_dom PF08771.11 ADV22841.1 - 3.9e-39 133.0 0.0 2.4e-38 130.5 0.0 2.5 2 0 0 2 2 2 1 FKBP12-rapamycin binding domain HEAT_2 PF13646.6 ADV22841.1 - 2.5e-11 43.8 5.4 0.024 15.0 0.0 7.7 6 1 1 7 7 7 4 HEAT repeats HEAT_EZ PF13513.6 ADV22841.1 - 1.5e-10 41.4 6.6 0.0047 17.4 0.1 8.5 11 0 0 11 11 7 2 HEAT-like repeat FATC PF02260.20 ADV22841.1 - 6.8e-10 38.6 0.1 1.7e-09 37.3 0.1 1.8 1 0 0 1 1 1 1 FATC domain HEAT PF02985.22 ADV22841.1 - 1.1e-08 34.5 7.9 0.00081 19.4 0.0 9.0 9 0 0 9 9 9 1 HEAT repeat Vac14_Fab1_bd PF12755.7 ADV22841.1 - 2.5e-07 31.2 1.9 2 9.1 0.3 6.9 7 1 0 7 7 7 1 Vacuolar 14 Fab1-binding region Sec7_N PF12783.7 ADV22841.1 - 0.0011 18.9 1.2 0.18 11.7 0.0 4.4 4 1 0 4 4 4 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF3437 PF11919.8 ADV22841.1 - 0.026 14.4 0.0 2.8 7.9 0.0 4.0 3 0 0 3 3 3 0 Domain of unknown function (DUF3437) Dicer_dimer PF03368.14 ADV22841.1 - 0.14 12.3 0.0 0.43 10.8 0.0 1.9 1 0 0 1 1 1 0 Dicer dimerisation domain Ribonuclease_3 PF00636.26 ADV22842.1 - 2e-11 44.4 0.1 9.7e-11 42.2 0.0 2.2 2 0 0 2 2 2 1 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 ADV22842.1 - 4.8e-09 36.5 0.0 7.9e-09 35.7 0.0 1.3 1 0 0 1 1 1 1 Ribonuclease-III-like dsrm PF00035.26 ADV22842.1 - 0.028 15.1 0.0 0.064 14.0 0.0 1.7 1 0 0 1 1 1 0 Double-stranded RNA binding motif DND1_DSRM PF14709.7 ADV22842.1 - 0.042 14.1 0.2 0.15 12.4 0.2 2.0 1 1 0 1 1 1 0 double strand RNA binding domain from DEAD END PROTEIN 1 THF_DHG_CYH PF00763.23 ADV22843.1 - 7.3e-24 84.3 0.0 1.2e-23 83.6 0.0 1.4 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain THF_DHG_CYH_C PF02882.19 ADV22843.1 - 4.8e-14 52.0 0.9 3.7e-08 32.8 0.0 2.7 2 2 0 2 2 2 2 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Metallophos PF00149.28 ADV22844.1 - 1.3e-12 48.7 0.1 1.8e-12 48.2 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ADV22844.1 - 0.064 13.4 0.0 0.097 12.9 0.0 1.3 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain Plus-3 PF03126.18 ADV22845.1 - 5e-21 75.3 0.2 1.5e-20 73.8 0.0 1.9 2 0 0 2 2 2 1 Plus-3 domain DUF2781 PF10914.8 ADV22846.1 - 3.8e-38 131.2 6.8 4.3e-38 131.0 6.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2781) LrgA PF03788.14 ADV22846.1 - 0.014 15.4 0.2 0.043 13.8 0.2 1.9 1 1 0 1 1 1 0 LrgA family TP_methylase PF00590.20 ADV22847.1 - 1.1e-16 61.4 0.0 5.6e-15 55.8 0.0 2.1 2 0 0 2 2 2 2 Tetrapyrrole (Corrin/Porphyrin) Methylases Rhomboid PF01694.22 ADV22848.1 - 2e-31 109.0 7.2 2e-31 109.0 7.2 1.9 2 0 0 2 2 2 1 Rhomboid family COX4_pro_2 PF07835.12 ADV22848.1 - 0.57 10.3 3.0 12 6.1 3.3 2.4 2 0 0 2 2 2 0 Bacterial aa3 type cytochrome c oxidase subunit IV MIT PF04212.18 ADV22849.1 - 4.6e-06 26.6 0.1 1.1e-05 25.3 0.1 1.7 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain DUF4745 PF15923.5 ADV22849.1 - 0.06 13.3 0.0 0.27 11.2 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4745) WXG100 PF06013.12 ADV22849.1 - 1.7 8.9 3.6 12 6.2 0.1 2.8 2 1 1 3 3 3 0 Proteins of 100 residues with WXG UCR_hinge PF02320.16 ADV22851.1 - 3.1e-23 81.7 6.4 6.1e-23 80.8 6.4 1.5 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase hinge protein DUF2052 PF09747.9 ADV22851.1 - 0.059 13.5 5.3 0.069 13.3 5.3 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) TRI5 PF06330.11 ADV22851.1 - 0.1 11.4 0.0 0.13 11.1 0.0 1.1 1 0 0 1 1 1 0 Trichodiene synthase (TRI5) GOLD_2 PF13897.6 ADV22851.1 - 0.16 12.5 1.8 0.22 12.0 1.8 1.2 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking DUF2828 PF11443.8 ADV22851.1 - 0.19 9.8 1.1 0.24 9.4 1.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Pox_Ag35 PF03286.14 ADV22851.1 - 0.78 9.5 4.9 0.87 9.3 4.9 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein HSP90 PF00183.18 ADV22851.1 - 1.8 7.4 6.1 2.1 7.2 6.1 1.1 1 0 0 1 1 1 0 Hsp90 protein DNA_pol_phi PF04931.13 ADV22851.1 - 3.1 5.8 5.2 3.1 5.8 5.2 1.1 1 0 0 1 1 1 0 DNA polymerase phi RabGAP-TBC PF00566.18 ADV22852.1 - 4.2e-17 62.5 0.2 5.9e-16 58.8 0.2 2.1 1 1 0 1 1 1 1 Rab-GTPase-TBC domain Phosphorylase PF00343.20 ADV22853.1 - 1.3e-296 985.7 0.0 1.6e-296 985.4 0.0 1.1 1 0 0 1 1 1 1 Carbohydrate phosphorylase Fringe PF02434.16 ADV22853.1 - 0.11 11.9 0.0 0.19 11.1 0.0 1.2 1 0 0 1 1 1 0 Fringe-like PX PF00787.24 ADV22855.1 - 1.5e-15 57.1 0.0 3.4e-15 56.0 0.0 1.6 1 0 0 1 1 1 1 PX domain Glyco_hydro_20 PF00728.22 ADV22857.1 - 5.2e-88 295.8 0.0 6.4e-88 295.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 ADV22857.1 - 4.3e-08 33.9 0.0 9.1e-08 32.9 0.0 1.6 1 0 0 1 1 1 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.15 ADV22857.1 - 0.079 13.7 0.0 0.31 11.8 0.0 2.0 2 1 0 2 2 2 0 Glycosyl hydrolase family 20, domain 2 Peptidase_C13 PF01650.18 ADV22859.1 - 1.7e-43 149.0 0.5 2.2e-43 148.6 0.5 1.1 1 0 0 1 1 1 1 Peptidase C13 family SUKH_5 PF14567.6 ADV22859.1 - 0.077 12.7 0.1 5 6.9 0.1 2.5 2 0 0 2 2 2 0 SMI1-KNR4 cell-wall DUF4943 PF16301.5 ADV22859.1 - 0.096 12.7 0.0 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4943) PSD3 PF07626.11 ADV22859.1 - 0.098 13.2 0.0 0.28 11.7 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1587) TB2_DP1_HVA22 PF03134.19 ADV22860.1 - 1.7e-28 98.3 2.9 3e-28 97.6 2.9 1.4 1 0 0 1 1 1 1 TB2/DP1, HVA22 family p450 PF00067.22 ADV22861.1 - 6.8e-45 153.7 0.1 1.3e-44 152.8 0.0 1.4 2 0 0 2 2 2 1 Cytochrome P450 MiaE PF06175.11 ADV22861.1 - 0.068 12.8 0.1 0.11 12.1 0.1 1.3 1 0 0 1 1 1 0 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE) RNA_pol_Rpc34 PF05158.12 ADV22862.1 - 1e-86 291.4 16.7 1.6e-79 267.7 7.9 2.5 3 0 0 3 3 3 2 RNA polymerase Rpc34 subunit RPA_C PF08784.11 ADV22862.1 - 2.8e-05 24.7 0.8 0.00028 21.5 0.1 2.8 2 0 0 2 2 2 1 Replication protein A C terminal MDM1 PF15501.6 ADV22862.1 - 0.05 12.8 33.7 0.082 12.0 33.7 1.3 1 0 0 1 1 1 0 Nuclear protein MDM1 DUF4778 PF16008.5 ADV22862.1 - 0.14 12.2 15.6 0.34 10.9 15.6 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4778) DUF572 PF04502.13 ADV22862.1 - 1.7 8.2 32.9 4.3 6.9 29.4 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF572) Borrelia_P83 PF05262.11 ADV22862.1 - 1.7 7.0 31.7 2.7 6.4 31.7 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein SLC12 PF03522.15 ADV22862.1 - 2.4 7.1 18.5 4.9 6.1 18.5 1.6 1 0 0 1 1 1 0 Solute carrier family 12 DUF4407 PF14362.6 ADV22862.1 - 9 5.5 12.8 15 4.8 12.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) XRN_M PF17846.1 ADV22862.1 - 9.2 5.1 15.7 17 4.2 15.7 1.5 1 0 0 1 1 1 0 Xrn1 helical domain CRT10 PF08728.10 ADV22862.1 - 9.4 4.3 14.5 14 3.7 14.5 1.2 1 0 0 1 1 1 0 CRT10 RINGv PF12906.7 ADV22863.1 - 1.3e-15 57.2 6.7 2.7e-15 56.2 6.7 1.6 1 0 0 1 1 1 1 RING-variant domain Cys_Met_Meta_PP PF01053.20 ADV22863.1 - 0.045 12.3 0.0 0.079 11.5 0.0 1.3 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme zf-RING_2 PF13639.6 ADV22863.1 - 0.25 11.7 7.0 0.48 10.8 7.0 1.5 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4_3 PF13920.6 ADV22863.1 - 4.8 7.1 5.3 9.6 6.2 5.3 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Malic_M PF03949.15 ADV22864.1 - 5.7e-95 317.4 0.0 7.6e-95 317.0 0.0 1.2 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 ADV22864.1 - 2.8e-57 193.5 0.0 3.5e-56 189.9 0.0 2.2 1 1 0 1 1 1 1 Malic enzyme, N-terminal domain UCH PF00443.29 ADV22865.1 - 2.7e-46 158.2 0.0 3.4e-46 157.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ADV22865.1 - 1e-10 41.8 0.0 2.6e-09 37.1 0.0 2.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 ADV22865.1 - 2.3e-09 37.5 4.7 2.3e-09 37.5 4.7 2.3 3 0 0 3 3 3 1 Zn-finger in ubiquitin-hydrolases and other protein DNA_pol_E_B PF04042.16 ADV22866.1 - 5.8e-52 176.1 0.0 8.1e-52 175.6 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B DNA_pol_D_N PF18018.1 ADV22866.1 - 0.017 15.2 0.1 0.047 13.8 0.1 1.7 1 0 0 1 1 1 0 DNA polymerase delta subunit OB-fold domain Ribosomal_S19 PF00203.21 ADV22867.1 - 4.1e-34 116.3 0.4 6.4e-34 115.7 0.4 1.3 1 0 0 1 1 1 1 Ribosomal protein S19 DUF1967 PF09269.11 ADV22867.1 - 0.17 11.9 0.2 0.4 10.7 0.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF1967) ABC1 PF03109.16 ADV22868.1 - 5e-26 91.2 0.0 9.1e-26 90.4 0.0 1.5 1 0 0 1 1 1 1 ABC1 family APH PF01636.23 ADV22868.1 - 5.3e-07 29.8 0.1 0.034 14.0 0.0 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family RIO1 PF01163.22 ADV22868.1 - 0.0014 18.3 0.0 0.0027 17.3 0.0 1.4 1 0 0 1 1 1 1 RIO1 family Pkinase PF00069.25 ADV22868.1 - 0.0036 16.7 0.0 0.0064 15.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain WaaY PF06176.11 ADV22868.1 - 0.02 14.5 0.0 0.036 13.7 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) Tim44 PF04280.15 ADV22869.1 - 4e-38 130.8 0.1 7.7e-38 129.9 0.1 1.5 1 0 0 1 1 1 1 Tim44-like domain Plexin_cytopl PF08337.12 ADV22869.1 - 0.057 12.1 0.6 3 6.4 0.0 2.1 2 0 0 2 2 2 0 Plexin cytoplasmic RasGAP domain Aldedh PF00171.22 ADV22871.1 - 3.1e-189 629.3 0.3 3.9e-189 629.0 0.3 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 ADV22871.1 - 0.026 13.6 0.0 0.039 13.0 0.0 1.2 1 0 0 1 1 1 0 Acyl-CoA reductase (LuxC) Stk19 PF10494.9 ADV22871.1 - 0.072 12.8 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Serine-threonine protein kinase 19 DUF1487 PF07368.11 ADV22871.1 - 0.072 12.5 0.0 7.3 6.0 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1487) DUF5633 PF18656.1 ADV22871.1 - 0.68 9.9 2.9 22 5.0 0.1 3.0 3 0 0 3 3 3 0 Family of unknown function (DUF5633) FF PF01846.19 ADV22872.1 - 4.5e-27 94.0 18.4 1e-12 48.0 0.0 7.1 7 0 0 7 7 7 3 FF domain WW PF00397.26 ADV22872.1 - 2.2e-10 40.4 17.9 6.7e-06 26.1 3.5 3.0 3 0 0 3 3 3 2 WW domain SAM_3 PF18016.1 ADV22872.1 - 0.12 12.2 0.3 0.24 11.2 0.3 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) HPPK PF01288.20 ADV22872.1 - 0.52 10.8 5.3 4 8.0 0.1 3.5 3 1 1 4 4 4 0 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) Arm-DNA-bind_4 PF14657.6 ADV22872.1 - 5.5 6.8 8.9 0.14 11.9 0.2 2.9 3 0 0 3 3 3 0 Arm DNA-binding domain SEP PF08059.13 ADV22873.1 - 2e-22 79.5 0.6 4.6e-22 78.4 0.1 1.9 2 0 0 2 2 2 1 SEP domain UBX PF00789.20 ADV22873.1 - 3.6e-13 49.5 0.1 5.6e-13 48.9 0.1 1.3 1 0 0 1 1 1 1 UBX domain UBA_4 PF14555.6 ADV22873.1 - 5.8e-08 32.4 1.0 9.8e-08 31.7 1.0 1.4 1 0 0 1 1 1 1 UBA-like domain BATS PF06968.13 ADV22875.1 - 1.4e-21 76.4 0.0 3.3e-21 75.2 0.0 1.7 1 0 0 1 1 1 1 Biotin and Thiamin Synthesis associated domain Radical_SAM PF04055.21 ADV22875.1 - 1.5e-15 58.0 0.0 2.3e-15 57.3 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily Bac_surface_Ag PF01103.23 ADV22877.1 - 1.2e-30 107.1 0.0 1.6e-30 106.7 0.0 1.2 1 0 0 1 1 1 1 Surface antigen 5_nucleotid_C PF02872.18 ADV22878.1 - 1.9e-26 93.2 0.0 1.6e-25 90.2 0.0 2.1 1 1 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 ADV22878.1 - 8.4e-10 39.5 0.3 4e-09 37.3 0.1 2.0 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Sde2_N_Ubi PF13019.6 ADV22879.1 - 5.6e-42 143.4 0.1 5.6e-42 143.4 0.1 2.0 2 0 0 2 2 2 1 Silencing defective 2 N-terminal ubiquitin domain RNA_pol_Rpb2_6 PF00562.28 ADV22880.1 - 9.9e-112 373.8 0.0 1.8e-111 373.0 0.0 1.4 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 ADV22880.1 - 4.9e-38 130.7 0.0 1.1e-37 129.5 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_3 PF04565.16 ADV22880.1 - 8.5e-29 99.5 0.1 3.8e-28 97.4 0.0 2.2 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpa2_4 PF06883.12 ADV22880.1 - 1.4e-23 82.6 0.0 3e-23 81.6 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_7 PF04560.20 ADV22880.1 - 1.8e-19 69.9 0.3 2.5e-17 63.0 0.3 2.6 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_2 PF04561.14 ADV22880.1 - 1.3e-18 67.3 0.0 2.2e-18 66.6 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 MFS_1 PF07690.16 ADV22881.1 - 4.2e-27 95.0 33.5 4.2e-27 95.0 33.5 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily FAD_binding_3 PF01494.19 ADV22882.1 - 1.9e-17 63.5 0.0 3.5e-13 49.5 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 ADV22882.1 - 0.00028 21.1 0.1 0.0013 18.9 0.1 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 ADV22882.1 - 0.0015 18.1 0.0 0.0032 17.1 0.0 1.5 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 ADV22882.1 - 0.0041 16.4 0.0 0.0069 15.6 0.0 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.14 ADV22882.1 - 0.0047 16.2 0.0 0.0062 15.8 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase SE PF08491.10 ADV22882.1 - 0.011 14.8 0.0 0.1 11.6 0.0 2.0 2 0 0 2 2 2 0 Squalene epoxidase FAD_binding_2 PF00890.24 ADV22882.1 - 0.015 14.4 0.0 0.022 13.9 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain NAD_binding_9 PF13454.6 ADV22882.1 - 0.041 13.9 0.0 0.077 13.0 0.0 1.4 1 0 0 1 1 1 0 FAD-NAD(P)-binding AlaDh_PNT_C PF01262.21 ADV22882.1 - 0.059 12.7 0.1 0.17 11.2 0.0 1.7 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain PSDC PF12588.8 ADV22883.1 - 3.6e-53 179.3 0.0 5.6e-53 178.7 0.0 1.3 1 0 0 1 1 1 1 Phophatidylserine decarboxylase PS_Dcarbxylase PF02666.15 ADV22883.1 - 2e-42 145.0 0.8 8.9e-42 142.9 0.0 1.9 2 0 0 2 2 2 1 Phosphatidylserine decarboxylase Biotin_lipoyl_2 PF13533.6 ADV22883.1 - 0.0037 17.1 2.3 0.28 11.1 1.3 2.4 2 0 0 2 2 2 1 Biotin-lipoyl like RnfC_N PF13375.6 ADV22883.1 - 0.029 14.3 0.0 2.4 8.2 0.0 2.5 2 0 0 2 2 2 0 RnfC Barrel sandwich hybrid domain Peptidase_M23 PF01551.22 ADV22883.1 - 0.073 13.3 0.1 0.21 11.8 0.1 1.7 1 0 0 1 1 1 0 Peptidase family M23 Biotin_lipoyl PF00364.22 ADV22883.1 - 0.12 12.3 0.1 1.1 9.1 0.1 2.3 2 0 0 2 2 2 0 Biotin-requiring enzyme Ribosomal_S5 PF00333.20 ADV22884.1 - 1.5e-28 98.6 0.8 3.5e-28 97.4 0.8 1.7 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 ADV22884.1 - 3.7e-24 84.0 0.0 6.1e-24 83.3 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain DASH_Ask1 PF08655.10 ADV22887.1 - 5.4e-25 87.1 0.2 9.9e-25 86.2 0.2 1.5 1 0 0 1 1 1 1 DASH complex subunit Ask1 Fungal_trans PF04082.18 ADV22888.1 - 1.4e-13 50.5 0.1 6.1e-13 48.4 0.0 1.9 2 0 0 2 2 2 1 Fungal specific transcription factor domain 2-Hacid_dh_C PF02826.19 ADV22890.1 - 3.7e-47 160.0 0.0 5.2e-47 159.5 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 ADV22890.1 - 2.8e-22 78.8 0.0 3.7e-22 78.4 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 ADV22890.1 - 1.5e-05 25.2 0.0 4.6e-05 23.6 0.0 1.7 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase AlaDh_PNT_C PF01262.21 ADV22890.1 - 0.016 14.5 0.0 0.39 10.0 0.0 2.2 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain DUF3884 PF13024.6 ADV22890.1 - 0.045 13.3 0.0 8.1 6.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3884) DUF5427 PF10310.9 ADV22891.1 - 8.8e-44 150.2 3.6 8.3e-36 123.9 0.1 3.3 1 1 1 2 2 2 2 Family of unknown function (DUF5427) SOG2 PF10428.9 ADV22891.1 - 4 6.5 12.3 7.4 5.6 12.3 1.4 1 0 0 1 1 1 0 RAM signalling pathway protein Vps8 PF12816.7 ADV22892.1 - 3.3e-68 229.1 0.0 1.2e-67 227.2 0.0 2.0 2 0 0 2 2 2 1 Golgi CORVET complex core vacuolar protein 8 Clathrin PF00637.20 ADV22892.1 - 0.0005 20.0 0.0 0.39 10.6 0.0 3.0 3 0 0 3 3 3 2 Region in Clathrin and VPS ANAPC4_WD40 PF12894.7 ADV22892.1 - 0.15 12.3 0.0 1.8 8.9 0.0 2.4 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Peptidase_C2 PF00648.21 ADV22893.1 - 1.9e-09 37.0 0.1 4.9e-09 35.6 0.1 1.6 1 1 0 1 1 1 1 Calpain family cysteine protease Chorismate_bind PF00425.18 ADV22894.1 - 7.5e-88 294.4 0.0 1.3e-87 293.7 0.0 1.4 1 0 0 1 1 1 1 chorismate binding enzyme Anth_synt_I_N PF04715.13 ADV22894.1 - 6.8e-27 94.4 0.0 2e-26 92.9 0.0 1.9 1 0 0 1 1 1 1 Anthranilate synthase component I, N terminal region ZZ PF00569.17 ADV22895.1 - 2.1e-13 49.9 45.5 7e-07 29.0 2.5 6.0 6 0 0 6 6 6 3 Zinc finger, ZZ type PB1 PF00564.24 ADV22895.1 - 1.1e-09 38.1 0.0 2.1e-09 37.1 0.0 1.4 1 0 0 1 1 1 1 PB1 domain C1_2 PF03107.16 ADV22895.1 - 0.0008 19.7 36.1 0.02 15.2 5.0 5.3 5 0 0 5 5 5 3 C1 domain zinc_ribbon_5 PF13719.6 ADV22895.1 - 0.068 12.9 0.2 0.068 12.9 0.2 3.9 4 0 0 4 4 4 0 zinc-ribbon domain Complex1_30kDa PF00329.19 ADV22896.1 - 9.1e-46 155.5 0.0 1.3e-45 155.0 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit WD40 PF00400.32 ADV22898.1 - 3.2e-12 46.8 9.2 0.0092 16.8 0.0 6.4 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV22898.1 - 4.4e-05 23.7 0.0 0.24 11.7 0.0 3.8 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nefa_Nip30_N PF10187.9 ADV22899.1 - 9.2e-27 93.5 17.7 9.2e-27 93.5 17.7 1.9 2 1 1 3 3 3 1 N-terminal domain of NEFA-interacting nuclear protein NIP30 RIBIOP_C PF04950.12 ADV22899.1 - 0.59 9.5 3.1 0.81 9.1 3.1 1.3 1 0 0 1 1 1 0 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal Dynamin_N PF00350.23 ADV22900.1 - 2.2e-16 60.3 0.2 2.2e-16 60.3 0.2 2.1 3 0 0 3 3 2 1 Dynamin family MMR_HSR1 PF01926.23 ADV22900.1 - 2.3e-14 53.5 0.1 1.9e-13 50.5 0.1 2.6 2 1 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ADV22900.1 - 1.9e-09 37.3 0.8 2.1e-08 34.0 0.5 2.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ADV22900.1 - 0.00011 22.2 1.4 0.33 10.9 0.0 3.1 3 1 0 3 3 3 2 RsgA GTPase cobW PF02492.19 ADV22900.1 - 0.00012 21.8 0.1 0.36 10.4 0.1 2.7 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain AAA_16 PF13191.6 ADV22900.1 - 0.0057 17.0 0.1 0.023 15.1 0.1 2.1 1 0 0 1 1 1 1 AAA ATPase domain TniB PF05621.11 ADV22900.1 - 0.013 14.9 0.0 0.032 13.6 0.0 1.6 1 0 0 1 1 1 0 Bacterial TniB protein FeoB_N PF02421.18 ADV22900.1 - 0.014 14.9 0.0 2.5 7.6 0.0 2.5 2 0 0 2 2 2 0 Ferrous iron transport protein B Arf PF00025.21 ADV22900.1 - 0.021 14.3 0.5 1 8.8 0.0 2.8 2 1 1 3 3 3 0 ADP-ribosylation factor family AAA_25 PF13481.6 ADV22900.1 - 0.031 13.9 0.2 1.4 8.5 0.0 2.9 3 0 0 3 3 3 0 AAA domain TsaE PF02367.17 ADV22900.1 - 0.063 13.3 0.0 0.26 11.3 0.0 2.0 3 0 0 3 3 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AIG1 PF04548.16 ADV22900.1 - 0.079 12.3 0.1 0.78 9.0 0.0 2.3 2 0 0 2 2 2 0 AIG1 family AAA_29 PF13555.6 ADV22900.1 - 0.098 12.4 0.0 0.24 11.2 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Septin PF00735.18 ADV22900.1 - 0.12 11.6 0.0 0.21 10.8 0.0 1.3 1 0 0 1 1 1 0 Septin Roc PF08477.13 ADV22900.1 - 0.16 12.2 0.7 1.7 8.8 0.0 2.8 3 1 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase Acetyltransf_1 PF00583.25 ADV22902.1 - 5.8e-12 45.9 0.0 7e-12 45.6 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ADV22902.1 - 2.3e-06 27.9 0.0 3.4e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ADV22902.1 - 0.0002 21.3 0.0 0.00025 21.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Transthyretin PF00576.21 ADV22903.1 - 1.5e-36 125.4 0.0 1.7e-36 125.2 0.0 1.0 1 0 0 1 1 1 1 HIUase/Transthyretin family bMG3 PF11974.8 ADV22903.1 - 0.0051 16.8 0.3 0.094 12.8 0.2 2.1 1 1 0 1 1 1 1 Bacterial alpha-2-macroglobulin MG3 domain Big_1 PF02369.16 ADV22903.1 - 0.1 12.6 0.2 0.55 10.3 0.2 1.9 1 1 0 1 1 1 0 Bacterial Ig-like domain (group 1) CarboxypepD_reg PF13620.6 ADV22903.1 - 0.13 12.6 0.1 0.27 11.5 0.1 1.6 1 1 0 1 1 1 0 Carboxypeptidase regulatory-like domain WD40 PF00400.32 ADV22904.1 - 9.5e-13 48.4 1.5 0.18 12.7 0.1 6.6 6 0 0 6 6 6 5 WD domain, G-beta repeat Pkinase PF00069.25 ADV22905.1 - 1.2e-53 182.2 0.0 1.6e-53 181.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV22905.1 - 3.8e-25 88.7 0.1 1.2e-24 87.1 0.1 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ADV22905.1 - 0.00019 20.8 0.0 0.00032 20.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 ADV22905.1 - 0.00039 20.4 0.1 0.1 12.5 0.0 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family RIO1 PF01163.22 ADV22905.1 - 0.015 14.9 0.1 0.029 14.0 0.1 1.4 1 1 0 1 1 1 0 RIO1 family FTA2 PF13095.6 ADV22905.1 - 0.021 14.5 0.0 4.5 6.8 0.0 2.2 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 ADV22905.1 - 0.056 12.8 0.5 0.088 12.1 0.5 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Gp_dh_C PF02800.20 ADV22906.1 - 1.3e-68 229.6 0.0 1.7e-68 229.2 0.0 1.2 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 ADV22906.1 - 1.1e-38 131.7 0.2 2.2e-38 130.6 0.2 1.6 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.20 ADV22906.1 - 0.021 15.0 0.1 0.068 13.3 0.0 1.9 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus Bmt2 PF11968.8 ADV22907.1 - 8.2e-78 261.2 0.0 1.1e-77 260.8 0.0 1.2 1 0 0 1 1 1 1 25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2 Methyltransf_23 PF13489.6 ADV22907.1 - 0.00045 20.1 0.0 0.0013 18.6 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ADV22907.1 - 0.006 17.2 0.0 0.014 16.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ADV22907.1 - 0.0062 17.3 0.0 0.021 15.5 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 ADV22907.1 - 0.0099 16.6 0.0 0.019 15.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain DREV PF05219.12 ADV22907.1 - 0.029 13.5 0.1 0.046 12.8 0.1 1.2 1 0 0 1 1 1 0 DREV methyltransferase PGAP1 PF07819.13 ADV22908.1 - 1.1e-61 208.6 0.0 1.5e-61 208.1 0.0 1.2 1 0 0 1 1 1 1 PGAP1-like protein Hydrolase_4 PF12146.8 ADV22908.1 - 4.7e-05 22.8 0.1 0.00044 19.6 0.0 2.1 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ADV22908.1 - 0.00024 21.8 0.0 0.00041 21.0 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF676 PF05057.14 ADV22908.1 - 0.0024 17.4 0.0 0.0046 16.5 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) DUF3099 PF11298.8 ADV22908.1 - 0.0097 16.0 3.0 0.083 13.0 3.6 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3099) Abhydrolase_1 PF00561.20 ADV22908.1 - 0.044 13.4 0.0 0.1 12.2 0.0 1.5 2 0 0 2 2 2 0 alpha/beta hydrolase fold Abhydrolase_8 PF06259.12 ADV22908.1 - 0.1 12.2 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase TPT PF03151.16 ADV22909.1 - 4.3e-61 206.8 21.8 5.3e-61 206.5 21.8 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 ADV22909.1 - 1.9e-09 37.8 31.0 7.2e-06 26.2 10.3 2.4 2 1 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 ADV22909.1 - 2.1e-05 23.9 20.8 2.7e-05 23.6 20.8 1.1 1 0 0 1 1 1 1 UAA transporter family DUF4536 PF15055.6 ADV22909.1 - 0.083 13.1 0.0 0.99 9.7 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4536) Gpr1_Fun34_YaaH PF01184.19 ADV22910.1 - 7.6e-81 270.6 15.4 9.6e-81 270.3 15.4 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family DUF4212 PF13937.6 ADV22910.1 - 0.28 11.6 8.6 0.098 13.0 4.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4212) DUF202 PF02656.15 ADV22910.1 - 9.7 6.7 15.3 23 5.5 0.2 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF202) MARVEL PF01284.23 ADV22911.1 - 9.6e-10 38.7 9.2 2.6e-09 37.2 9.4 1.6 1 1 0 1 1 1 1 Membrane-associating domain WTF PF03303.13 ADV22911.1 - 0.01 15.6 1.8 0.01 15.5 0.2 1.9 2 0 0 2 2 2 0 WTF protein DUF998 PF06197.13 ADV22911.1 - 0.061 12.9 9.4 6.8 6.2 7.4 2.6 1 1 0 2 2 2 0 Protein of unknown function (DUF998) SIT PF15330.6 ADV22911.1 - 0.069 13.6 0.9 2.9 8.4 0.0 3.1 3 0 0 3 3 3 0 SHP2-interacting transmembrane adaptor protein, SIT DUF1673 PF07895.11 ADV22911.1 - 0.11 12.3 0.4 0.25 11.0 0.1 1.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1673) Ninjurin PF04923.12 ADV22911.1 - 2.1 8.4 4.3 2.8 7.9 2.9 2.0 2 1 1 3 3 3 0 Ninjurin DUF1772 PF08592.11 ADV22911.1 - 7 7.0 8.2 26 5.1 8.2 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF1772) SUR7 PF06687.12 ADV22911.1 - 7.1 6.2 14.9 3.1 7.4 0.1 2.4 1 1 1 2 2 2 0 SUR7/PalI family ISG65-75 PF11727.8 ADV22912.1 - 0.0011 18.3 1.9 0.0013 18.1 1.9 1.0 1 0 0 1 1 1 1 Invariant surface glycoprotein DUF883 PF05957.13 ADV22912.1 - 0.1 13.2 5.5 0.86 10.2 1.6 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) Chlorosome_CsmC PF11098.8 ADV22912.1 - 0.27 11.2 4.4 0.56 10.2 4.4 1.6 1 1 0 1 1 1 0 Chlorosome envelope protein C YtxH PF12732.7 ADV22912.1 - 0.46 11.1 8.6 34 5.1 8.6 2.1 1 1 0 1 1 1 0 YtxH-like protein Aa_trans PF01490.18 ADV22913.1 - 2.6e-37 128.5 32.2 3.2e-37 128.2 32.2 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein LapA_dom PF06305.11 ADV22913.1 - 0.41 10.5 0.1 0.41 10.5 0.1 4.0 4 1 1 5 5 5 0 Lipopolysaccharide assembly protein A domain DUF3040 PF11239.8 ADV22913.1 - 0.88 9.9 0.0 0.88 9.9 0.0 5.3 5 0 0 5 5 5 0 Protein of unknown function (DUF3040) DUF680 PF05079.12 ADV22914.1 - 0.12 13.1 3.8 0.44 11.3 3.8 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF680) ATP-synt_F PF01990.17 ADV22915.1 - 5.8e-29 100.3 0.1 7e-29 100.0 0.1 1.1 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit DXP_synthase_N PF13292.6 ADV22915.1 - 0.02 14.1 0.0 0.02 14.1 0.0 1.1 1 0 0 1 1 1 0 1-deoxy-D-xylulose-5-phosphate synthase Hist_deacetyl PF00850.19 ADV22916.1 - 1.9e-84 283.7 0.0 3e-84 283.1 0.0 1.3 1 0 0 1 1 1 1 Histone deacetylase domain SRRM_C PF15230.6 ADV22916.1 - 0.59 10.7 6.0 1.3 9.6 6.0 1.6 1 0 0 1 1 1 0 Serine/arginine repetitive matrix protein C-terminus CDC45 PF02724.14 ADV22916.1 - 9.2 4.4 10.9 13 4.0 10.9 1.1 1 0 0 1 1 1 0 CDC45-like protein SID-1_RNA_chan PF13965.6 ADV22917.1 - 0.57 8.5 10.0 0.56 8.5 7.6 1.8 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 SNARE PF05739.19 ADV22917.1 - 0.91 9.6 4.8 0.51 10.4 0.7 2.4 2 0 0 2 2 2 0 SNARE domain DUF3852 PF12963.7 ADV22917.1 - 1.3 9.3 11.8 0.27 11.6 5.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3852) Pkinase PF00069.25 ADV22918.1 - 2.9e-65 220.3 0.0 3.5e-65 220.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV22918.1 - 1.5e-18 67.0 0.0 2.1e-18 66.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ADV22918.1 - 4.6e-08 33.3 0.0 1.8e-05 24.8 0.1 2.5 1 1 0 2 2 2 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ADV22918.1 - 0.0077 15.1 0.0 0.016 14.0 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 ADV22918.1 - 0.033 13.6 0.2 0.057 12.8 0.1 1.4 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 ADV22918.1 - 0.039 13.5 0.9 0.054 13.1 0.0 1.7 2 0 0 2 2 2 0 Choline/ethanolamine kinase Kinase-like PF14531.6 ADV22918.1 - 0.047 13.0 0.0 0.062 12.6 0.0 1.2 1 0 0 1 1 1 0 Kinase-like BCAS2 PF05700.11 ADV22920.1 - 1.6e-43 148.9 0.3 1.9e-43 148.6 0.3 1.0 1 0 0 1 1 1 1 Breast carcinoma amplified sequence 2 (BCAS2) AAA_13 PF13166.6 ADV22920.1 - 0.0052 15.5 0.1 0.0059 15.3 0.1 1.0 1 0 0 1 1 1 1 AAA domain GAS PF13851.6 ADV22920.1 - 0.014 14.8 0.2 0.024 14.0 0.2 1.3 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding DASH_Hsk3 PF08227.11 ADV22920.1 - 0.021 15.2 2.0 0.021 15.2 2.0 2.0 2 0 0 2 2 2 0 DASH complex subunit Hsk3 like DivIC PF04977.15 ADV22920.1 - 0.041 13.6 0.4 0.46 10.3 0.1 2.3 2 0 0 2 2 2 0 Septum formation initiator DUF4715 PF15835.5 ADV22920.1 - 0.11 12.6 0.1 0.19 11.8 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4715) Jnk-SapK_ap_N PF09744.9 ADV22920.1 - 0.18 12.0 2.6 0.29 11.3 1.2 1.9 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 DUF1318 PF07027.12 ADV22920.1 - 0.37 11.3 3.0 0.43 11.1 0.8 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF1318) Med5 PF08689.10 ADV22921.1 - 1.2e-16 59.8 0.0 2.3e-16 58.9 0.0 1.3 1 0 0 1 1 1 1 Mediator complex subunit Med5 Sds3 PF08598.11 ADV22922.1 - 8.7e-13 48.8 0.5 1.3e-12 48.3 0.5 1.2 1 0 0 1 1 1 1 Sds3-like DUF2267 PF10025.9 ADV22922.1 - 0.075 13.3 0.8 0.15 12.3 0.8 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2267) DUF4149 PF13664.6 ADV22923.1 - 7.2e-19 68.0 0.7 1.7e-18 66.8 0.6 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4149) DUF1772 PF08592.11 ADV22923.1 - 0.018 15.3 0.1 0.026 14.9 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1772) Pkinase PF00069.25 ADV22924.1 - 1.2e-57 195.3 0.0 1.8e-57 194.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV22924.1 - 1.5e-27 96.5 0.0 2.3e-27 95.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ADV22924.1 - 0.00057 19.3 0.0 0.0011 18.3 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 ADV22924.1 - 0.012 15.5 1.0 1.7 8.5 0.1 2.8 2 1 1 3 3 3 0 Phosphotransferase enzyme family Kdo PF06293.14 ADV22924.1 - 0.027 13.8 0.0 0.049 13.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 ADV22924.1 - 0.074 12.7 0.0 2.2 7.8 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 PHF5 PF03660.14 ADV22925.1 - 2.2e-51 172.4 10.4 2.5e-51 172.2 10.4 1.0 1 0 0 1 1 1 1 PHF5-like protein PolC_DP2 PF03833.13 ADV22925.1 - 0.47 8.2 6.2 0.53 8.1 6.2 1.2 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 DZR PF12773.7 ADV22925.1 - 0.61 10.2 16.2 1.4 9.1 2.2 2.8 1 1 1 2 2 2 0 Double zinc ribbon TauD PF02668.16 ADV22926.1 - 2.5e-40 139.0 0.1 4.7e-40 138.1 0.0 1.4 2 0 0 2 2 2 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.12 ADV22926.1 - 3.4e-07 30.8 0.0 7.2e-07 29.8 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF971) CsiD PF08943.10 ADV22926.1 - 0.0026 16.9 0.0 0.019 14.1 0.0 2.0 2 0 0 2 2 2 1 CsiD TLD PF07534.16 ADV22927.1 - 3.4e-32 111.6 0.2 5.5e-32 110.9 0.2 1.3 1 0 0 1 1 1 1 TLD HAD_2 PF13419.6 ADV22928.1 - 3.9e-18 66.2 0.0 7.9e-12 45.6 0.0 2.2 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ADV22928.1 - 1.9e-12 48.0 0.0 5e-12 46.6 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ADV22928.1 - 1e-06 28.7 0.1 2.5e-06 27.5 0.1 1.7 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 ADV22928.1 - 0.0042 17.5 0.1 0.053 13.9 0.0 2.3 2 1 1 3 3 3 1 haloacid dehalogenase-like hydrolase ADH_zinc_N PF00107.26 ADV22928.1 - 0.0044 17.0 0.2 0.0095 15.9 0.2 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Phage_r1t_holin PF16945.5 ADV22928.1 - 0.96 9.7 5.2 2.7 8.3 0.3 2.5 2 0 0 2 2 2 0 Putative lactococcus lactis phage r1t holin DUF4112 PF13430.6 ADV22929.1 - 8.7e-10 38.8 0.3 1.2e-09 38.4 0.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4112) DcuA_DcuB PF03605.14 ADV22929.1 - 0.047 12.6 0.1 0.063 12.2 0.1 1.1 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter zf-C3HC4 PF00097.25 ADV22930.1 - 1.9e-08 34.0 8.3 2.9e-08 33.5 8.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ADV22930.1 - 8.5e-08 32.4 9.7 1.3e-07 31.8 9.7 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 ADV22930.1 - 3.5e-07 30.0 6.0 5.2e-07 29.4 6.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ADV22930.1 - 4.8e-07 29.5 8.9 7.6e-07 28.9 8.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ADV22930.1 - 4.4e-06 26.6 7.9 8.5e-06 25.7 7.9 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 ADV22930.1 - 2.1e-05 24.6 7.3 3.2e-05 24.0 7.3 1.3 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 ADV22930.1 - 0.00021 21.1 7.9 0.00037 20.3 7.9 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 ADV22930.1 - 0.00038 20.4 2.2 0.00063 19.7 2.2 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.6 ADV22930.1 - 0.0012 18.8 7.5 0.0022 17.9 7.5 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_6 PF14835.6 ADV22930.1 - 0.13 12.2 4.1 0.1 12.5 2.4 1.7 2 0 0 2 2 2 0 zf-RING of BARD1-type protein zf-rbx1 PF12678.7 ADV22930.1 - 0.34 11.2 13.1 1.2 9.5 13.1 1.8 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_4 PF14570.6 ADV22930.1 - 0.37 10.6 6.5 0.66 9.8 6.5 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_10 PF16685.5 ADV22930.1 - 0.6 10.3 4.2 1 9.5 4.2 1.4 1 0 0 1 1 1 0 zinc RING finger of MSL2 DiS_P_DiS PF06750.13 ADV22930.1 - 0.85 9.8 3.3 22 5.3 3.3 2.3 1 1 0 1 1 1 0 Bacterial Peptidase A24 N-terminal domain zf-RING_11 PF17123.5 ADV22930.1 - 1.1 9.0 5.1 2.5 7.9 5.1 1.6 1 0 0 1 1 1 0 RING-like zinc finger GCFC PF07842.12 ADV22931.1 - 5.3e-65 219.8 12.1 6.5e-47 160.5 9.0 2.6 2 1 1 3 3 3 2 GC-rich sequence DNA-binding factor-like protein G-patch PF01585.23 ADV22931.1 - 1.1e-10 41.2 2.2 3.2e-10 39.7 2.2 1.9 1 0 0 1 1 1 1 G-patch domain TIP_N PF12457.8 ADV22931.1 - 1.6e-07 31.6 4.3 1.6e-07 31.6 4.3 3.2 2 1 1 3 3 3 1 Tuftelin interacting protein N terminal G-patch_2 PF12656.7 ADV22931.1 - 0.48 10.5 3.0 1.8 8.7 0.1 3.1 3 0 0 3 3 3 0 G-patch domain MMR_HSR1_Xtn PF16897.5 ADV22932.1 - 7.3e-38 128.8 1.5 9.9e-38 128.4 0.3 1.8 2 0 0 2 2 2 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 ADV22932.1 - 1.4e-21 76.3 0.0 2.4e-21 75.5 0.0 1.4 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.23 ADV22932.1 - 4.3e-19 68.7 0.0 1e-18 67.5 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ADV22932.1 - 5.6e-11 42.2 0.0 1.1e-10 41.3 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 ADV22932.1 - 0.0015 18.6 0.2 0.026 14.6 0.0 2.4 1 1 1 2 2 2 1 Dynamin family MCM PF00493.23 ADV22932.1 - 0.03 13.4 0.1 0.069 12.2 0.0 1.6 2 0 0 2 2 2 0 MCM P-loop domain PACT_coil_coil PF10495.9 ADV22933.1 - 9.1e-18 64.6 0.2 9.1e-18 64.6 0.2 4.6 4 1 0 4 4 4 1 Pericentrin-AKAP-450 domain of centrosomal targeting protein Spc110_C PF18520.1 ADV22933.1 - 0.0035 16.9 1.1 0.0086 15.7 0.1 2.3 2 0 0 2 2 2 1 Spindle pole body component 110 C-terminal domain DUF2443 PF10398.9 ADV22933.1 - 0.27 11.3 3.9 0.65 10.1 0.8 3.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2443) Strep_SA_rep PF06696.11 ADV22933.1 - 2.2 8.4 15.3 0.19 11.8 3.0 3.7 3 0 0 3 3 3 0 Streptococcal surface antigen repeat Surp PF01805.20 ADV22934.1 - 4.6e-11 42.5 0.1 1.3e-10 41.1 0.1 1.8 1 0 0 1 1 1 1 Surp module RRM_1 PF00076.22 ADV22934.1 - 1.9e-10 40.4 0.0 9.3e-10 38.2 0.0 2.3 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CTK3 PF12243.8 ADV22934.1 - 0.00057 19.9 0.0 0.0011 18.9 0.0 1.4 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 CTD_bind PF04818.13 ADV22934.1 - 0.0062 17.3 0.0 0.02 15.7 0.0 2.0 1 0 0 1 1 1 1 RNA polymerase II-binding domain. RRM_7 PF16367.5 ADV22934.1 - 0.054 13.6 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif Limkain-b1 PF11608.8 ADV22934.1 - 0.19 11.9 1.2 1.3 9.1 0.0 2.9 3 0 0 3 3 3 0 Limkain b1 MitMem_reg PF13012.6 ADV22936.1 - 1.1e-22 80.6 0.2 1.7e-22 79.9 0.2 1.3 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.21 ADV22936.1 - 4.2e-14 52.5 0.0 9.3e-13 48.2 0.0 2.2 1 1 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Sel1 PF08238.12 ADV22937.1 - 3.5e-49 164.1 16.9 1.7e-08 34.9 0.0 7.5 7 0 0 7 7 7 7 Sel1 repeat ACBP PF00887.19 ADV22938.1 - 6.2e-20 71.2 0.0 1.2e-19 70.3 0.0 1.5 1 0 0 1 1 1 1 Acyl CoA binding protein Ank_5 PF13857.6 ADV22938.1 - 1.5e-14 53.8 0.0 1.7e-13 50.5 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ADV22938.1 - 1e-11 45.2 0.0 2e-11 44.3 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 ADV22938.1 - 1.1e-11 44.6 0.0 1.6e-06 28.3 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 ADV22938.1 - 2.1e-11 44.1 0.0 8.9e-09 35.7 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ADV22938.1 - 1e-06 28.5 0.0 0.0001 22.5 0.0 3.1 3 0 0 3 3 3 1 Ankyrin repeat RhoGEF PF00621.20 ADV22939.1 - 2.7e-30 106.0 0.1 4.9e-30 105.1 0.1 1.4 1 0 0 1 1 1 1 RhoGEF domain Ribonuc_L-PSP PF01042.21 ADV22940.1 - 1.4e-11 44.4 0.0 2.3e-11 43.8 0.0 1.3 1 0 0 1 1 1 1 Endoribonuclease L-PSP ERM PF00769.19 ADV22941.1 - 0.00095 19.1 37.1 0.014 15.2 19.0 3.1 3 0 0 3 3 3 2 Ezrin/radixin/moesin family Velvet PF11754.8 ADV22943.1 - 1.5e-28 100.4 0.1 3.3e-20 73.1 0.0 2.0 1 1 1 2 2 2 2 Velvet factor SAP PF02037.27 ADV22944.1 - 0.0041 16.8 1.1 0.01 15.6 0.0 2.2 2 0 0 2 2 2 1 SAP domain Tropomyosin_1 PF12718.7 ADV22945.1 - 4e-43 147.0 32.7 5e-43 146.7 32.7 1.1 1 0 0 1 1 1 1 Tropomyosin like Tropomyosin PF00261.20 ADV22945.1 - 7.8e-11 41.8 35.3 2.2e-05 24.0 15.0 3.2 1 1 2 3 3 3 3 Tropomyosin GAS PF13851.6 ADV22945.1 - 9.5e-05 21.8 31.9 0.0017 17.7 11.0 2.4 1 1 1 2 2 2 2 Growth-arrest specific micro-tubule binding KELK PF15796.5 ADV22945.1 - 0.00064 20.1 5.5 0.00064 20.1 5.5 3.3 2 1 1 3 3 3 2 KELK-motif containing domain of MRCK Ser/Thr protein kinase DUF3450 PF11932.8 ADV22945.1 - 0.001 18.4 24.6 0.0037 16.6 11.7 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF3450) Cep57_CLD_2 PF14197.6 ADV22945.1 - 0.0083 16.2 4.0 0.0083 16.2 4.0 3.5 1 1 2 3 3 3 1 Centrosome localisation domain of PPC89 CENP-F_leu_zip PF10473.9 ADV22945.1 - 0.01 15.9 9.9 0.01 15.9 9.9 2.8 1 1 1 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 HrpB7 PF09486.10 ADV22945.1 - 0.04 14.3 23.5 0.21 11.9 23.5 2.0 1 1 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) ATG16 PF08614.11 ADV22945.1 - 0.078 13.2 32.4 0.14 12.3 19.3 2.2 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Fez1 PF06818.15 ADV22945.1 - 0.087 13.3 28.5 0.15 12.5 28.3 1.4 1 1 0 1 1 1 0 Fez1 DUF4407 PF14362.6 ADV22945.1 - 0.087 12.2 18.0 0.11 11.8 18.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Sec34 PF04136.15 ADV22945.1 - 0.094 12.6 14.1 0.024 14.5 4.3 2.3 1 1 1 2 2 2 0 Sec34-like family APG6_N PF17675.1 ADV22945.1 - 0.098 13.2 41.2 0.032 14.8 27.1 2.1 1 1 1 2 2 2 0 Apg6 coiled-coil region Lebercilin PF15619.6 ADV22945.1 - 0.14 11.8 33.8 0.37 10.4 22.7 2.5 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Borrelia_P83 PF05262.11 ADV22945.1 - 0.16 10.5 23.5 0.2 10.1 23.5 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein Csm1_N PF18504.1 ADV22945.1 - 0.18 12.1 30.2 0.073 13.4 10.1 3.5 1 1 2 3 3 3 0 Csm1 N-terminal domain UPF0242 PF06785.11 ADV22945.1 - 0.23 11.5 32.3 0.042 14.0 14.9 2.0 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF3584 PF12128.8 ADV22945.1 - 0.24 8.9 31.6 0.45 8.0 31.6 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) DUF1664 PF07889.12 ADV22945.1 - 0.25 11.4 17.2 0.086 12.9 3.7 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Jnk-SapK_ap_N PF09744.9 ADV22945.1 - 0.27 11.4 34.5 0.031 14.5 24.0 2.0 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 DUF724 PF05266.14 ADV22945.1 - 0.31 10.9 28.4 0.7 9.7 9.6 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF724) Fib_alpha PF08702.10 ADV22945.1 - 0.39 10.9 15.6 0.28 11.4 6.1 2.2 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family FemAB PF02388.16 ADV22945.1 - 0.4 9.5 20.1 0.054 12.4 6.1 2.0 2 0 0 2 2 2 0 FemAB family PI3K_P85_iSH2 PF16454.5 ADV22945.1 - 0.46 10.1 24.4 0.11 12.1 19.8 1.8 1 1 1 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain TPR_MLP1_2 PF07926.12 ADV22945.1 - 0.56 10.3 36.1 3.5 7.7 8.0 2.8 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DLP_helical PF18709.1 ADV22945.1 - 0.79 8.9 21.2 0.14 11.3 4.2 2.9 1 1 2 3 3 3 0 Dynamin-like helical domain DHR10 PF18595.1 ADV22945.1 - 0.95 9.5 39.1 3.6 7.7 15.1 2.5 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain ERM PF00769.19 ADV22945.1 - 0.98 9.2 38.0 0.14 11.9 17.1 2.0 1 1 1 2 2 2 0 Ezrin/radixin/moesin family IFT46_B_C PF12317.8 ADV22945.1 - 1.1 9.0 6.9 1.3 8.7 6.9 1.2 1 0 0 1 1 1 0 Intraflagellar transport complex B protein 46 C terminal COG2 PF06148.11 ADV22945.1 - 1.1 9.3 21.3 1.3 9.1 9.6 2.5 1 1 2 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 EzrA PF06160.12 ADV22945.1 - 1.2 7.2 24.0 0.13 10.4 9.3 2.0 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA MAD PF05557.13 ADV22945.1 - 1.5 7.1 30.2 0.15 10.4 18.6 1.9 1 1 0 1 1 1 0 Mitotic checkpoint protein TMF_DNA_bd PF12329.8 ADV22945.1 - 1.5 8.9 36.0 13 5.8 14.0 3.6 1 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding HMMR_N PF15905.5 ADV22945.1 - 1.5 8.2 31.6 5.1 6.5 31.3 1.7 1 1 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Seryl_tRNA_N PF02403.22 ADV22945.1 - 1.5 9.1 28.4 0.3 11.3 13.5 3.0 1 1 2 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Laminin_II PF06009.12 ADV22945.1 - 1.6 8.7 18.4 1.2 9.1 6.0 2.3 1 1 1 2 2 2 0 Laminin Domain II Uso1_p115_C PF04871.13 ADV22945.1 - 1.7 9.0 35.6 0.41 11.0 14.0 2.3 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF812 PF05667.11 ADV22945.1 - 1.8 7.4 29.5 2.8 6.7 29.5 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF812) BRE1 PF08647.11 ADV22945.1 - 2 8.6 27.9 3.1 7.9 10.2 2.9 1 1 2 3 3 3 0 BRE1 E3 ubiquitin ligase Spc7 PF08317.11 ADV22945.1 - 2 7.2 32.8 19 4.0 31.9 2.0 1 1 0 1 1 1 0 Spc7 kinetochore protein Lectin_N PF03954.14 ADV22945.1 - 2.2 8.0 14.0 2.1 8.1 5.8 3.1 1 1 2 3 3 3 0 Hepatic lectin, N-terminal domain CC2-LZ PF16516.5 ADV22945.1 - 2.5 8.5 30.4 0.14 12.5 6.4 3.7 1 1 2 3 3 3 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator SlyX PF04102.12 ADV22945.1 - 2.6 8.7 25.6 0.2 12.3 8.3 3.8 1 1 2 3 3 3 0 SlyX Leu_zip PF15294.6 ADV22945.1 - 3 7.3 25.2 0.88 9.0 7.4 2.0 1 1 1 2 2 2 0 Leucine zipper BLOC1_2 PF10046.9 ADV22945.1 - 3.1 8.2 20.8 0.57 10.5 9.0 3.1 1 1 2 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 LMBR1 PF04791.16 ADV22945.1 - 3.1 6.6 12.1 3.9 6.3 12.1 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Snapin_Pallidin PF14712.6 ADV22945.1 - 3.8 8.0 20.8 9.5 6.7 5.5 2.7 1 1 2 3 3 3 0 Snapin/Pallidin LIN37 PF15306.6 ADV22945.1 - 3.9 7.7 11.5 7 6.8 11.5 1.5 1 1 0 1 1 1 0 LIN37 Mod_r PF07200.13 ADV22945.1 - 3.9 7.6 28.9 1.9 8.6 9.6 2.5 1 1 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein DUF4201 PF13870.6 ADV22945.1 - 4.1 7.1 26.5 7.8 6.2 13.8 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) Prefoldin PF02996.17 ADV22945.1 - 4.3 7.3 25.4 0.47 10.4 2.3 4.0 1 1 3 4 4 4 0 Prefoldin subunit Serine_rich PF08824.10 ADV22945.1 - 4.7 7.2 15.3 1.2 9.2 3.0 2.8 1 1 1 2 2 2 0 Serine rich protein interaction domain FliD_C PF07195.12 ADV22945.1 - 4.7 6.6 13.7 2.8 7.3 7.3 2.7 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 C-terminus Occludin_ELL PF07303.13 ADV22945.1 - 4.7 8.0 17.7 2.8 8.7 5.5 3.1 1 1 3 4 4 4 0 Occludin homology domain Syntaxin_2 PF14523.6 ADV22945.1 - 5 7.5 14.3 3.8 7.9 10.2 2.3 1 1 1 2 2 2 0 Syntaxin-like protein Exonuc_VII_L PF02601.15 ADV22945.1 - 5.9 6.4 20.1 11 5.5 20.1 1.5 1 1 0 1 1 1 0 Exonuclease VII, large subunit DUF2703 PF10865.8 ADV22945.1 - 6.4 7.0 11.7 11 6.2 1.4 3.1 1 1 2 3 3 3 0 Domain of unknown function (DUF2703) XhlA PF10779.9 ADV22945.1 - 7.9 6.8 25.9 1.2 9.4 3.2 4.1 2 1 2 4 4 4 0 Haemolysin XhlA HHV-5_US34A PF17087.5 ADV22945.1 - 9.8 6.4 6.4 2.8 8.2 3.3 1.8 2 0 0 2 2 1 0 Herpesvirus US34A protein family RhoGAP PF00620.27 ADV22946.1 - 2e-35 121.8 0.1 3.8e-35 121.0 0.1 1.4 1 0 0 1 1 1 1 RhoGAP domain LIM PF00412.22 ADV22946.1 - 1.3e-16 60.5 34.3 1.5e-11 44.4 8.9 4.5 4 0 0 4 4 4 4 LIM domain Flavin_Reduct PF01613.18 ADV22947.1 - 1.8e-55 187.2 5.5 1.8e-54 184.0 5.5 2.0 1 1 0 1 1 1 1 Flavin reductase like domain PX PF00787.24 ADV22948.1 - 1e-24 86.7 0.0 1.2e-24 86.4 0.0 1.1 1 0 0 1 1 1 1 PX domain DUF1338 PF07063.13 ADV22948.1 - 0.098 11.8 0.1 0.28 10.3 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1338) IKI3 PF04762.12 ADV22949.1 - 4.3e-230 766.4 0.0 3.8e-229 763.2 0.0 2.0 1 1 0 1 1 1 1 IKI3 family ANAPC4_WD40 PF12894.7 ADV22949.1 - 0.01 16.1 1.0 6.9 7.0 0.1 4.4 5 1 0 5 5 5 0 Anaphase-promoting complex subunit 4 WD40 domain TPR_2 PF07719.17 ADV22949.1 - 0.064 13.4 0.9 0.36 11.0 0.9 2.4 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_1 PF00515.28 ADV22949.1 - 0.08 12.8 0.3 0.21 11.5 0.3 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat Snf7 PF03357.21 ADV22950.1 - 2.9e-48 163.7 10.7 3.4e-48 163.5 10.7 1.1 1 0 0 1 1 1 1 Snf7 NPV_P10 PF05531.12 ADV22950.1 - 0.0036 17.7 1.4 4.3 7.9 0.1 2.9 2 1 1 3 3 3 2 Nucleopolyhedrovirus P10 protein Prefoldin_2 PF01920.20 ADV22950.1 - 0.015 15.2 9.1 0.53 10.3 0.0 3.2 2 1 2 4 4 4 0 Prefoldin subunit Prefoldin PF02996.17 ADV22950.1 - 0.049 13.5 6.1 2.8 7.9 0.1 3.0 3 0 0 3 3 3 0 Prefoldin subunit FlaC_arch PF05377.11 ADV22950.1 - 0.094 13.1 5.4 0.36 11.2 0.1 3.2 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) DHR10 PF18595.1 ADV22950.1 - 0.32 11.1 12.5 0.26 11.3 0.4 3.0 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain Uso1_p115_C PF04871.13 ADV22950.1 - 1 9.7 12.2 1.1 9.6 7.6 2.4 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Macoilin PF09726.9 ADV22950.1 - 1.7 7.1 7.8 2.2 6.7 7.8 1.3 1 1 0 1 1 1 0 Macoilin family DUF2730 PF10805.8 ADV22950.1 - 1.7 8.8 6.7 0.88 9.7 0.3 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF2730) DASH_Hsk3 PF08227.11 ADV22950.1 - 2.6 8.5 7.7 18 5.8 0.0 3.3 3 1 0 3 3 3 0 DASH complex subunit Hsk3 like FapA PF03961.13 ADV22950.1 - 3.5 6.1 8.8 0.57 8.7 2.8 1.8 1 1 1 2 2 2 0 Flagellar Assembly Protein A APG6_N PF17675.1 ADV22950.1 - 6.7 7.3 10.2 1.4 9.4 3.1 2.4 1 1 1 2 2 2 0 Apg6 coiled-coil region MFS_1 PF07690.16 ADV22951.1 - 1.5e-36 126.0 57.8 1.8e-36 125.8 55.1 2.2 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 ADV22951.1 - 2.9e-11 42.5 16.6 2.9e-11 42.5 16.6 1.7 2 1 1 3 3 3 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 ADV22951.1 - 0.0004 19.4 6.4 0.0004 19.4 6.4 3.5 2 1 2 4 4 4 2 Sugar (and other) transporter Phosducin PF02114.16 ADV22952.1 - 1.7e-09 37.0 1.5 2.5e-08 33.2 1.5 2.2 1 1 0 1 1 1 1 Phosducin adh_short PF00106.25 ADV22953.1 - 1.1e-90 302.3 19.0 1e-45 155.6 4.5 2.8 3 0 0 3 3 3 2 short chain dehydrogenase adh_short_C2 PF13561.6 ADV22953.1 - 2.3e-74 249.9 13.0 3.2e-37 128.3 2.5 2.3 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase MaoC_dehydratas PF01575.19 ADV22953.1 - 2.2e-31 108.0 0.0 4.6e-31 106.9 0.0 1.5 1 0 0 1 1 1 1 MaoC like domain KR PF08659.10 ADV22953.1 - 8e-30 104.1 9.1 2.2e-16 60.3 1.4 2.3 2 0 0 2 2 2 2 KR domain MaoC_dehydrat_N PF13452.6 ADV22953.1 - 2.8e-05 24.3 0.0 0.00042 20.5 0.0 2.3 2 0 0 2 2 2 1 N-terminal half of MaoC dehydratase 2-Hacid_dh_C PF02826.19 ADV22953.1 - 0.00011 21.6 1.8 0.25 10.7 0.0 3.6 4 0 0 4 4 4 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 ADV22953.1 - 0.04 13.8 10.2 0.14 12.1 2.4 2.5 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain THF_DHG_CYH_C PF02882.19 ADV22953.1 - 0.052 12.9 1.2 0.97 8.7 0.1 2.4 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain tRNA-synt_2c PF01411.19 ADV22954.1 - 7e-212 704.8 0.0 8.9e-212 704.5 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 ADV22954.1 - 1.2e-16 60.5 0.3 3.5e-16 59.0 0.3 1.9 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.19 ADV22954.1 - 3.5e-11 43.7 6.3 8.7e-11 42.4 6.3 1.7 1 0 0 1 1 1 1 DHHA1 domain Glycophorin_A PF01102.18 ADV22955.1 - 0.0035 17.6 0.4 0.01 16.1 0.0 1.9 2 0 0 2 2 2 1 Glycophorin A VSP PF03302.13 ADV22955.1 - 0.0041 16.0 3.7 0.008 15.1 3.7 1.4 1 0 0 1 1 1 1 Giardia variant-specific surface protein DUF4690 PF15756.5 ADV22955.1 - 0.0067 17.0 1.1 0.038 14.6 1.1 2.3 1 0 0 1 1 1 1 Small Novel Rich in Cartilage Podoplanin PF05808.11 ADV22955.1 - 0.0089 16.1 4.9 0.022 14.9 4.9 1.6 1 0 0 1 1 1 1 Podoplanin EMC3_TMCO1 PF01956.16 ADV22956.1 - 1.7e-47 161.3 0.0 2e-47 161.1 0.0 1.1 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like SipA_VBS PF17985.1 ADV22958.1 - 0.014 15.2 0.3 0.63 10.0 0.1 2.8 2 0 0 2 2 2 0 SipA vinculin binding site Abhydrolase_2 PF02230.16 ADV22959.1 - 5.6e-64 215.9 0.0 2.1e-63 214.0 0.0 1.7 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_6 PF12697.7 ADV22959.1 - 1.9e-06 28.6 0.2 2.3e-06 28.4 0.2 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ADV22959.1 - 2.8e-06 26.8 0.2 0.068 12.4 0.0 3.1 2 1 1 3 3 3 2 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 ADV22959.1 - 5.3e-05 23.2 0.0 0.0001 22.3 0.0 1.4 2 0 0 2 2 2 1 alpha/beta hydrolase fold FSH1 PF03959.13 ADV22959.1 - 0.00023 20.9 0.0 0.00065 19.4 0.0 1.7 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_1 PF00561.20 ADV22959.1 - 0.0013 18.5 3.4 0.4 10.3 2.8 3.1 1 1 1 2 2 2 1 alpha/beta hydrolase fold Lipase_3 PF01764.25 ADV22959.1 - 0.0017 18.2 0.0 0.003 17.4 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) DLH PF01738.18 ADV22959.1 - 0.0021 17.7 0.0 0.0041 16.7 0.0 1.5 1 1 0 1 1 1 1 Dienelactone hydrolase family AXE1 PF05448.12 ADV22959.1 - 0.018 13.7 0.0 0.026 13.2 0.0 1.2 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Esterase PF00756.20 ADV22959.1 - 0.078 12.6 0.0 0.1 12.2 0.0 1.3 1 0 0 1 1 1 0 Putative esterase DUF2974 PF11187.8 ADV22959.1 - 0.14 11.7 0.0 0.19 11.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) SH3_1 PF00018.28 ADV22960.1 - 1.7e-36 123.6 4.4 4.8e-15 54.9 0.3 4.2 4 0 0 4 4 4 3 SH3 domain SH3_9 PF14604.6 ADV22960.1 - 2.6e-33 113.7 6.0 5.2e-13 48.6 0.2 4.4 4 0 0 4 4 4 3 Variant SH3 domain SHD1 PF03983.12 ADV22960.1 - 5.5e-29 99.8 0.1 1.6e-28 98.3 0.0 1.8 2 0 0 2 2 2 1 SLA1 homology domain 1, SHD1 SH3_2 PF07653.17 ADV22960.1 - 2.6e-21 75.0 0.0 4.7e-08 32.6 0.0 4.3 4 0 0 4 4 4 3 Variant SH3 domain DUF1720 PF08226.11 ADV22960.1 - 2.3e-06 27.9 30.6 2.3e-06 27.9 30.6 6.6 3 1 3 6 6 6 2 Domain of unknown function (DUF1720) SH3_10 PF17902.1 ADV22960.1 - 6.6e-06 26.1 0.2 0.00011 22.2 0.0 2.9 3 0 0 3 3 3 1 SH3 domain SAM_4 PF18017.1 ADV22960.1 - 0.0017 18.3 0.0 0.0032 17.4 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) CCDC50_N PF15295.6 ADV22960.1 - 0.011 15.9 2.1 0.011 15.9 2.1 4.1 3 1 1 4 4 4 0 Coiled-coil domain-containing protein 50 N-terminus SH3_4 PF06347.13 ADV22960.1 - 0.015 15.1 0.8 0.13 12.1 0.2 2.6 2 0 0 2 2 2 0 Bacterial SH3 domain SH3_3 PF08239.11 ADV22960.1 - 0.025 14.8 3.4 0.085 13.2 0.4 2.8 3 0 0 3 3 3 0 Bacterial SH3 domain hSH3 PF14603.6 ADV22960.1 - 0.068 13.6 0.0 0.36 11.3 0.0 2.2 2 0 0 2 2 2 0 Helically-extended SH3 domain SGL PF08450.12 ADV22961.1 - 4.8e-63 213.0 0.0 6.2e-63 212.6 0.0 1.1 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Reg_prop PF07494.11 ADV22961.1 - 0.004 17.2 0.4 2.2 8.8 0.0 2.8 2 0 0 2 2 2 2 Two component regulator propeller PD40 PF07676.12 ADV22961.1 - 0.11 12.5 1.8 0.14 12.2 0.1 2.1 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat 4HBT_2 PF13279.6 ADV22962.1 - 3.3e-07 30.8 0.0 6.7e-07 29.8 0.0 1.5 1 0 0 1 1 1 1 Thioesterase-like superfamily ANAPC10 PF03256.16 ADV22963.1 - 1.5e-47 161.6 0.0 1.8e-47 161.4 0.0 1.0 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) F5_F8_type_C PF00754.25 ADV22963.1 - 0.0075 16.4 0.0 0.0095 16.1 0.0 1.3 1 1 0 1 1 1 1 F5/8 type C domain GYF PF02213.16 ADV22964.1 - 3.7e-18 64.9 1.2 9.9e-18 63.5 1.2 1.8 1 0 0 1 1 1 1 GYF domain GYF_2 PF14237.6 ADV22964.1 - 3.2e-05 23.6 0.0 8e-05 22.4 0.0 1.7 1 0 0 1 1 1 1 GYF domain 2 Vta1 PF04652.16 ADV22965.1 - 2.9e-43 147.3 3.3 9.8e-43 145.6 2.1 2.0 2 0 0 2 2 2 1 Vta1 like Vta1_C PF18097.1 ADV22965.1 - 1.7e-16 59.6 0.1 3.2e-16 58.7 0.1 1.5 1 0 0 1 1 1 1 Vta1 C-terminal domain Ribosomal_L21p PF00829.21 ADV22967.1 - 8.6e-14 51.6 0.0 5.6e-13 49.0 0.0 1.9 1 1 0 1 1 1 1 Ribosomal prokaryotic L21 protein SPOR PF05036.13 ADV22967.1 - 0.0031 17.8 0.2 0.0073 16.7 0.0 1.7 2 0 0 2 2 2 1 Sporulation related domain NAT PF04768.13 ADV22968.1 - 1.5e-42 145.1 0.0 2.4e-42 144.5 0.0 1.3 1 0 0 1 1 1 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase Semialdhyde_dh PF01118.24 ADV22968.1 - 1.6e-32 112.5 0.0 3.1e-32 111.6 0.0 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain AA_kinase PF00696.28 ADV22968.1 - 5e-27 95.0 0.0 1.2e-26 93.8 0.0 1.6 1 0 0 1 1 1 1 Amino acid kinase family Semialdhyde_dhC PF02774.18 ADV22968.1 - 6.5e-09 36.1 0.0 1.5e-08 34.9 0.0 1.6 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, dimerisation domain DapB_N PF01113.20 ADV22968.1 - 0.028 14.5 0.0 0.091 12.9 0.0 2.0 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus DUF1640 PF07798.11 ADV22970.1 - 4e-60 202.9 11.1 4.7e-60 202.6 11.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) Thiamine_BP PF01910.17 ADV22970.1 - 0.064 13.2 0.7 0.18 11.7 0.2 2.0 1 1 1 2 2 2 0 Thiamine-binding protein Phage_lysis PF03245.13 ADV22970.1 - 2.4 8.3 10.5 1.1 9.4 4.1 2.2 1 1 1 2 2 2 0 Bacteriophage Rz lysis protein AMPK1_CBM PF16561.5 ADV22971.1 - 0.064 13.5 0.0 0.15 12.3 0.0 1.6 1 0 0 1 1 1 0 Glycogen recognition site of AMP-activated protein kinase CKS PF01111.19 ADV22973.1 - 8.9e-30 102.8 0.1 1.1e-29 102.5 0.1 1.1 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit DUF4887 PF16228.5 ADV22974.1 - 0.12 12.6 2.2 0.27 11.4 2.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4887) Ribosomal_S5_C PF03719.15 ADV22975.1 - 3.4e-14 52.0 0.1 6.8e-14 51.1 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain Ribosomal_S5 PF00333.20 ADV22975.1 - 1.4e-11 44.2 0.8 2.7e-11 43.3 0.8 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Cellulase PF00150.18 ADV22976.1 - 2.9e-24 86.0 4.2 2.7e-23 82.8 0.3 2.2 1 1 1 2 2 2 2 Cellulase (glycosyl hydrolase family 5) DUF1752 PF08550.10 ADV22977.1 - 1.7e-09 37.3 4.9 3.9e-09 36.2 4.9 1.6 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) Proteasome PF00227.26 ADV22978.1 - 1.8e-47 161.3 0.3 2.2e-47 161.0 0.3 1.1 1 0 0 1 1 1 1 Proteasome subunit Smr PF01713.21 ADV22979.1 - 4.8e-13 49.3 0.2 9.5e-13 48.3 0.1 1.6 2 0 0 2 2 2 1 Smr domain DUF1771 PF08590.10 ADV22979.1 - 2.1e-09 37.6 2.4 2.1e-09 37.6 2.4 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF1771) DUF1752 PF08550.10 ADV22980.1 - 5.3e-10 39.0 4.1 1e-09 38.0 4.1 1.5 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) Moricin PF06451.11 ADV22980.1 - 0.034 13.9 0.0 0.1 12.4 0.0 1.7 2 0 0 2 2 2 0 Moricin UQ_con PF00179.26 ADV22981.1 - 7.3e-18 64.6 0.1 9.3e-18 64.2 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Ribosomal_60s PF00428.19 ADV22982.1 - 2.2e-27 95.5 13.2 2.5e-27 95.3 13.2 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein ACC_central PF08326.12 ADV22983.1 - 1.5e-226 754.1 0.0 1.8e-226 753.8 0.0 1.1 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region Carboxyl_trans PF01039.22 ADV22983.1 - 1.8e-158 528.3 0.0 2.3e-158 527.9 0.0 1.1 1 0 0 1 1 1 1 Carboxyl transferase domain CPSase_L_D2 PF02786.17 ADV22983.1 - 2.3e-52 177.6 0.0 5.6e-52 176.3 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 ADV22983.1 - 6.7e-30 103.9 0.1 1.7e-29 102.5 0.1 1.8 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 ADV22983.1 - 7.1e-22 77.6 0.0 5.1e-21 74.8 0.0 2.5 3 0 0 3 3 3 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 ADV22983.1 - 4.9e-15 55.1 0.0 1.7e-14 53.4 0.0 2.0 1 0 0 1 1 1 1 Biotin-requiring enzyme ATP-grasp_3 PF02655.14 ADV22983.1 - 4.5e-05 23.6 0.0 0.00012 22.1 0.0 1.8 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.6 ADV22983.1 - 0.001 18.9 0.0 0.0064 16.3 0.0 2.4 2 0 0 2 2 2 1 Biotin-lipoyl like Dala_Dala_lig_C PF07478.13 ADV22983.1 - 0.0015 18.1 0.0 0.004 16.7 0.0 1.7 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus DUF1542 PF07564.11 ADV22983.1 - 0.24 11.5 1.9 0.61 10.2 1.9 1.7 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1542) Ribosomal_L28e PF01778.17 ADV22984.1 - 4.8e-39 133.7 1.6 4.8e-39 133.7 1.6 1.9 2 0 0 2 2 2 1 Ribosomal L28e protein family Mak16 PF04874.14 ADV22984.1 - 7.2e-29 100.3 16.4 7.2e-29 100.3 16.4 2.3 1 1 1 2 2 2 1 Mak16 protein C-terminal region BUD22 PF09073.10 ADV22984.1 - 4.6e-05 23.0 13.8 6.7e-05 22.4 13.8 1.2 1 0 0 1 1 1 1 BUD22 PYC_OADA PF02436.18 ADV22984.1 - 0.28 10.9 1.7 0.6 9.8 1.5 1.5 1 1 0 1 1 1 0 Conserved carboxylase domain Nop14 PF04147.12 ADV22984.1 - 0.4 8.8 21.2 0.51 8.5 21.2 1.2 1 0 0 1 1 1 0 Nop14-like family Kinesin PF00225.23 ADV22985.1 - 1.3e-71 241.3 0.5 1.3e-71 241.3 0.5 2.5 2 1 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 ADV22985.1 - 8.4e-25 87.4 0.1 1.1e-12 48.1 0.1 2.4 2 0 0 2 2 2 2 Microtubule binding EF-hand_8 PF13833.6 ADV22985.1 - 0.051 13.4 0.0 1.1 9.2 0.0 2.6 2 0 0 2 2 2 0 EF-hand domain pair ATP-synt_ab PF00006.25 ADV22986.1 - 2e-71 240.0 0.0 3.1e-71 239.4 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.27 ADV22986.1 - 4.6e-43 146.5 0.0 8.5e-43 145.7 0.0 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.23 ADV22986.1 - 3.3e-18 66.0 2.0 9.3e-18 64.5 2.0 1.8 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain zf-HC5HC2H_2 PF13832.6 ADV22987.1 - 4.1e-32 110.6 12.5 1.3e-31 109.0 7.0 2.4 2 0 0 2 2 2 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 ADV22987.1 - 2.4e-25 88.6 3.7 2.4e-25 88.6 3.7 3.0 3 0 0 3 3 3 2 PHD-like zinc-binding domain EPL1 PF10513.9 ADV22987.1 - 3.8e-25 89.1 1.3 3.8e-25 89.1 1.3 4.2 3 1 0 3 3 2 1 Enhancer of polycomb-like Bromodomain PF00439.25 ADV22987.1 - 1.1e-16 60.7 0.2 2.4e-16 59.6 0.2 1.6 1 0 0 1 1 1 1 Bromodomain PHD_2 PF13831.6 ADV22987.1 - 8.9e-15 54.0 3.0 8.9e-15 54.0 3.0 2.8 3 0 0 3 3 3 1 PHD-finger PWWP PF00855.17 ADV22987.1 - 4.2e-12 46.3 0.0 2e-11 44.1 0.0 2.3 1 0 0 1 1 1 1 PWWP domain PHD PF00628.29 ADV22987.1 - 1.5e-10 40.8 5.8 1.5e-10 40.8 5.8 3.1 3 0 0 3 3 3 2 PHD-finger zf-PHD-like PF15446.6 ADV22987.1 - 0.0062 16.2 1.1 0.0062 16.2 1.1 2.5 2 0 0 2 2 2 1 PHD/FYVE-zinc-finger like domain C1_1 PF00130.22 ADV22987.1 - 0.0093 15.8 0.9 0.0093 15.8 0.9 3.2 3 0 0 3 3 3 1 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF1028 PF06267.12 ADV22987.1 - 0.066 13.0 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF1028) zf-RING-like PF08746.11 ADV22987.1 - 0.19 12.0 20.2 0.019 15.3 6.2 3.0 3 0 0 3 3 3 0 RING-like domain Prok-RING_1 PF14446.6 ADV22987.1 - 0.76 9.8 13.4 0.14 12.2 3.3 2.6 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 Mei5 PF10376.9 ADV22988.1 - 1.5 8.6 6.1 0.4 10.5 0.1 2.6 2 1 0 3 3 3 0 Double-strand recombination repair protein ApbA_C PF08546.11 ADV22989.1 - 1.5e-29 102.7 0.1 2.1e-29 102.3 0.1 1.2 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 ADV22989.1 - 7.5e-25 87.4 0.0 1.2e-24 86.7 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Peptidase_M50 PF02163.22 ADV22990.1 - 3.6e-12 46.1 0.0 3.1e-05 23.4 0.0 3.1 2 1 0 2 2 2 2 Peptidase family M50 PDZ_2 PF13180.6 ADV22990.1 - 0.00028 21.1 0.0 0.00055 20.2 0.0 1.3 1 0 0 1 1 1 1 PDZ domain Prenyltrans PF00432.21 ADV22991.1 - 9.1e-20 70.1 13.9 5.1e-06 26.1 0.0 6.2 5 2 1 6 6 6 5 Prenyltransferase and squalene oxidase repeat Tim54 PF11711.8 ADV22991.1 - 0.026 13.3 0.0 0.044 12.6 0.0 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Laminin_B PF00052.18 ADV22992.1 - 0.0046 16.9 0.0 0.013 15.4 0.0 1.7 2 0 0 2 2 2 1 Laminin B (Domain IV) OPT PF03169.15 ADV22993.1 - 2.8e-168 561.4 24.9 3.2e-168 561.2 24.9 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein PBP1_TM PF14812.6 ADV22993.1 - 0.19 12.1 0.8 0.57 10.6 0.8 1.7 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal PTP_tm PF18861.1 ADV22994.1 - 0.023 14.7 0.0 0.041 13.9 0.0 1.3 1 0 0 1 1 1 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J SNARE PF05739.19 ADV22994.1 - 0.52 10.4 1.3 0.9 9.6 1.3 1.4 1 0 0 1 1 1 0 SNARE domain DUF155 PF02582.14 ADV22995.1 - 8.5e-50 169.3 0.0 1.2e-49 168.8 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 Glyoxal_oxid_N PF07250.11 ADV22996.1 - 2.5e-35 121.8 1.4 5.9e-26 91.1 0.0 3.5 2 1 0 3 3 3 3 Glyoxal oxidase N-terminus DUF1929 PF09118.11 ADV22996.1 - 2e-22 79.3 0.0 3.8e-22 78.4 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1929) Kelch_4 PF13418.6 ADV22996.1 - 0.0046 16.9 0.6 1.8 8.6 0.0 3.7 3 0 0 3 3 3 1 Galactose oxidase, central domain IlvN PF07991.12 ADV22997.1 - 3.7e-47 160.0 0.1 7.7e-47 158.9 0.1 1.5 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain IlvC PF01450.19 ADV22997.1 - 1.7e-40 138.7 0.0 2.9e-40 137.9 0.0 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain NAD_binding_2 PF03446.15 ADV22997.1 - 0.057 13.6 0.0 0.11 12.7 0.0 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase ADH_N PF08240.12 ADV22998.1 - 1.1e-20 73.5 0.5 1.1e-20 73.5 0.5 1.5 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ADV22998.1 - 3.1e-09 36.9 0.0 5.8e-09 36.0 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 ADV22998.1 - 0.014 14.7 0.2 0.024 13.9 0.2 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain SET PF00856.28 ADV22999.1 - 1.5e-06 28.7 0.0 7.2e-05 23.2 0.0 2.9 3 0 0 3 3 3 1 SET domain Rubis-subs-bind PF09273.11 ADV22999.1 - 0.0086 16.8 0.1 0.026 15.2 0.0 1.8 2 0 0 2 2 2 1 Rubisco LSMT substrate-binding Yae1_N PF09811.9 ADV23001.1 - 6.2e-11 41.8 1.2 6.2e-11 41.8 1.2 1.7 2 0 0 2 2 2 1 Essential protein Yae1, N terminal BTG PF07742.12 ADV23003.1 - 2.2e-10 40.4 0.0 4.8e-10 39.3 0.0 1.5 1 0 0 1 1 1 1 BTG family Pneumo_att_G PF05539.11 ADV23003.1 - 0.35 10.4 14.1 0.66 9.5 14.1 1.5 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G DMRL_synthase PF00885.19 ADV23004.1 - 4.7e-56 188.5 0.7 7.5e-56 187.9 0.7 1.3 1 1 0 1 1 1 1 6,7-dimethyl-8-ribityllumazine synthase INO80_Ies4 PF08193.11 ADV23004.1 - 0.027 14.5 1.9 0.037 14.0 1.9 1.1 1 0 0 1 1 1 0 INO80 complex subunit Ies4 DUF2561 PF10812.8 ADV23004.1 - 0.03 14.4 0.2 0.039 14.0 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2561) MGC-24 PF05283.11 ADV23004.1 - 0.22 12.0 3.4 0.32 11.4 3.4 1.2 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin DUF866 PF05907.13 ADV23005.1 - 8.9e-21 74.4 1.2 6.6e-20 71.6 1.2 1.9 1 1 0 1 1 1 1 Eukaryotic protein of unknown function (DUF866) UCH PF00443.29 ADV23006.1 - 3.6e-44 151.2 0.0 5e-44 150.7 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UBA PF00627.31 ADV23006.1 - 3.4e-23 81.2 0.1 1.3e-11 44.1 0.0 2.7 2 0 0 2 2 2 2 UBA/TS-N domain zf-UBP PF02148.19 ADV23006.1 - 1.4e-20 73.4 2.5 1.4e-19 70.1 1.3 2.8 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.6 ADV23006.1 - 1.9e-17 63.9 0.5 8.5e-09 35.4 1.0 3.1 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase CUE PF02845.16 ADV23006.1 - 0.18 11.6 0.0 0.39 10.5 0.0 1.6 1 0 0 1 1 1 0 CUE domain HEAT_2 PF13646.6 ADV23006.1 - 0.19 12.2 0.0 17 5.9 0.0 2.6 2 0 0 2 2 2 0 HEAT repeats SNARE_assoc PF09335.11 ADV23007.1 - 2.3e-08 34.5 4.2 2.3e-08 34.5 4.2 3.9 3 1 1 4 4 4 1 SNARE associated Golgi protein DUF4748 PF15932.5 ADV23007.1 - 0.081 12.7 0.1 0.22 11.3 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4748) DUF2615 PF11027.8 ADV23007.1 - 0.1 12.7 0.0 2.9 8.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2615) Holin_BhlA PF10960.8 ADV23007.1 - 0.3 11.1 1.0 3.3 7.7 0.1 2.3 2 0 0 2 2 2 0 BhlA holin family EOS1 PF12326.8 ADV23008.1 - 1.3e-28 100.2 5.7 2.4e-28 99.3 5.7 1.5 1 0 0 1 1 1 1 N-glycosylation protein EAP30 PF04157.16 ADV23009.1 - 3.3e-64 216.4 0.0 3.8e-64 216.2 0.0 1.0 1 0 0 1 1 1 1 EAP30/Vps36 family DnaJ PF00226.31 ADV23011.1 - 2.3e-16 59.7 0.1 4e-16 58.9 0.1 1.4 1 0 0 1 1 1 1 DnaJ domain Med16 PF11635.8 ADV23015.1 - 0.0082 14.1 3.7 0.034 12.1 3.8 1.8 1 1 0 1 1 1 1 Mediator complex subunit 16 2OG-FeII_Oxy_3 PF13640.6 ADV23016.1 - 1.8e-09 38.3 0.2 3.2e-09 37.6 0.2 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Dynein_light PF01221.18 ADV23017.1 - 1.2e-35 121.7 1.9 1.4e-35 121.5 1.9 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 TFIIB PF00382.19 ADV23018.1 - 1e-27 96.0 1.7 1.2e-15 57.2 1.2 2.4 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 ADV23018.1 - 0.015 14.8 1.3 0.52 9.9 1.3 2.5 1 1 0 1 1 1 0 TFIIB zinc-binding Met_10 PF02475.16 ADV23018.1 - 0.018 14.8 0.1 0.027 14.2 0.1 1.2 1 0 0 1 1 1 0 Met-10+ like-protein HTH_Tnp_ISL3 PF13542.6 ADV23018.1 - 0.15 11.5 0.0 2.9 7.4 0.0 2.5 2 0 0 2 2 2 0 Helix-turn-helix domain of transposase family ISL3 V-ATPase_G PF03179.15 ADV23019.1 - 1.1e-28 99.8 21.4 4.9e-28 97.7 21.4 1.8 1 1 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit DUF3552 PF12072.8 ADV23019.1 - 0.26 10.7 17.6 1.5 8.2 17.5 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF3552) ATP-synt_B PF00430.18 ADV23019.1 - 0.29 11.2 14.3 0.24 11.5 13.1 1.5 1 1 0 1 1 1 0 ATP synthase B/B' CF(0) Fib_alpha PF08702.10 ADV23019.1 - 0.32 11.2 8.0 0.41 10.8 8.0 1.1 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Seryl_tRNA_N PF02403.22 ADV23019.1 - 1 9.6 10.1 1.1 9.6 8.6 1.9 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain CemA PF03040.14 ADV23019.1 - 4.6 7.1 6.5 6 6.7 6.5 1.2 1 0 0 1 1 1 0 CemA family OPT PF03169.15 ADV23020.1 - 1.6e-119 400.4 47.3 1.9e-119 400.1 47.3 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein CcmD PF04995.14 ADV23020.1 - 2.8 8.1 6.3 0.23 11.5 0.1 2.6 2 0 0 2 2 2 0 Heme exporter protein D (CcmD) BofA PF07441.11 ADV23020.1 - 6.5 7.0 14.9 1.2 9.4 7.3 3.2 2 0 0 2 2 2 0 SigmaK-factor processing regulatory protein BofA Zds_C PF08632.10 ADV23021.1 - 3.1e-26 90.9 0.9 5.8e-26 90.0 0.9 1.4 1 0 0 1 1 1 1 Activator of mitotic machinery Cdc14 phosphatase activation C-term HTH_ABP1_N PF18107.1 ADV23021.1 - 0.067 12.9 0.0 0.18 11.5 0.0 1.7 1 0 0 1 1 1 0 Fission yeast centromere protein N-terminal domain AP3D1 PF06375.11 ADV23021.1 - 9.2 6.5 10.9 0.4 10.9 2.3 2.5 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 Proteasome PF00227.26 ADV23022.1 - 1.4e-51 174.7 0.0 1.1e-45 155.5 0.0 2.1 2 0 0 2 2 2 2 Proteasome subunit Proteasome_A_N PF10584.9 ADV23022.1 - 7.7e-14 51.1 0.1 1.5e-13 50.1 0.1 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Mob1_phocein PF03637.17 ADV23023.1 - 8.9e-63 211.3 2.9 1.1e-62 211.1 2.9 1.0 1 0 0 1 1 1 1 Mob1/phocein family DUF4080 PF13311.6 ADV23023.1 - 0.18 12.0 3.7 1.9 8.6 1.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4080) RasGAP PF00616.19 ADV23024.1 - 3.9e-29 101.9 0.1 1e-20 74.3 0.0 2.6 1 1 1 2 2 2 2 GTPase-activator protein for Ras-like GTPase CRAL_TRIO_2 PF13716.6 ADV23024.1 - 8.8e-08 32.4 0.1 2.6e-07 30.9 0.1 1.8 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain SRP9-21 PF05486.12 ADV23025.1 - 9.8e-09 35.5 4.2 2.4e-08 34.2 0.3 2.5 2 1 0 2 2 2 1 Signal recognition particle 9 kDa protein (SRP9) INO80_Ies4 PF08193.11 ADV23025.1 - 0.0016 18.5 1.4 0.0017 18.4 1.4 1.1 1 0 0 1 1 1 1 INO80 complex subunit Ies4 Ribosomal_L35Ae PF01247.18 ADV23027.1 - 1.2e-40 137.6 0.6 1.5e-40 137.3 0.6 1.1 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.18 ADV23027.1 - 3e-05 24.2 0.0 0.33 11.2 0.0 2.2 2 0 0 2 2 2 2 RimM N-terminal domain DAO PF01266.24 ADV23028.1 - 1.3e-24 87.5 0.2 2e-23 83.5 0.2 2.1 1 1 0 1 1 1 1 FAD dependent oxidoreductase Sds3 PF08598.11 ADV23029.1 - 3.6e-09 37.0 3.6 3.6e-09 37.0 3.6 1.5 1 1 0 1 1 1 1 Sds3-like OmpH PF03938.14 ADV23029.1 - 0.17 12.2 5.5 0.35 11.2 5.5 1.5 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Transcrip_act PF04949.13 ADV23029.1 - 2.1 8.2 8.1 0.56 10.1 4.6 1.7 2 0 0 2 2 2 0 Transcriptional activator SNARE_assoc PF09335.11 ADV23030.1 - 1.1e-13 51.8 7.9 1.1e-13 51.8 7.9 2.1 3 0 0 3 3 3 1 SNARE associated Golgi protein Oxidored_q2 PF00420.24 ADV23030.1 - 0.1 12.2 0.2 0.1 12.2 0.2 1.8 2 0 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L Smim3 PF17307.2 ADV23030.1 - 1.5 8.4 6.9 1.2 8.7 0.1 2.5 2 0 0 2 2 2 0 Small integral membrane protein 3 SpoVAB PF13782.6 ADV23030.1 - 2.2 8.6 10.4 0.12 12.7 3.2 2.6 2 2 1 3 3 3 0 Stage V sporulation protein AB Ferrochelatase PF00762.19 ADV23031.1 - 1.2e-109 366.3 0.0 1.4e-109 366.1 0.0 1.0 1 0 0 1 1 1 1 Ferrochelatase RNase_PH PF01138.21 ADV23032.1 - 5.7e-17 62.5 0.0 7.9e-17 62.0 0.0 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 SKN1 PF03935.15 ADV23033.1 - 1.5e-183 610.8 3.2 2.1e-183 610.3 3.2 1.1 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) adh_short PF00106.25 ADV23034.1 - 8.2e-25 87.4 0.1 3.6e-12 46.2 0.1 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 ADV23034.1 - 4.1e-15 56.0 0.1 8e-07 28.8 0.2 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ADV23034.1 - 0.0013 18.7 1.8 0.0027 17.6 0.2 1.9 2 0 0 2 2 2 1 KR domain Pyr_redox_2 PF07992.14 ADV23034.1 - 0.02 14.2 0.0 0.026 13.8 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 ADV23034.1 - 0.032 14.1 0.1 0.045 13.6 0.1 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NmrA PF05368.13 ADV23034.1 - 0.043 13.4 0.1 0.059 12.9 0.1 1.1 1 0 0 1 1 1 0 NmrA-like family THF_DHG_CYH_C PF02882.19 ADV23034.1 - 0.054 12.8 0.0 0.09 12.1 0.0 1.3 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Bac_luciferase PF00296.20 ADV23034.1 - 0.063 12.7 0.1 0.094 12.1 0.1 1.2 1 0 0 1 1 1 0 Luciferase-like monooxygenase WD40 PF00400.32 ADV23035.1 - 1.1e-08 35.5 4.9 1.2 10.1 0.0 5.5 5 1 0 5 5 5 4 WD domain, G-beta repeat tRNA_bind PF01588.20 ADV23036.1 - 6.2e-28 96.8 0.0 1.3e-27 95.7 0.0 1.6 1 0 0 1 1 1 1 Putative tRNA binding domain GST_C PF00043.25 ADV23036.1 - 0.33 11.2 1.8 1.1 9.5 0.0 2.5 2 1 0 2 2 2 0 Glutathione S-transferase, C-terminal domain OAD_gamma PF04277.13 ADV23036.1 - 0.7 10.5 16.5 0.66 10.6 0.2 2.8 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain MIF4G PF02854.19 ADV23037.1 - 6.8e-50 169.6 0.9 4.9e-29 101.5 0.0 4.0 4 1 0 4 4 4 2 MIF4G domain Upf2 PF04050.14 ADV23037.1 - 2.7e-27 96.2 8.8 2.7e-27 96.2 8.8 3.0 3 0 0 3 3 3 1 Up-frameshift suppressor 2 LPD38 PF18857.1 ADV23037.1 - 0.00086 19.5 0.0 0.0037 17.4 0.0 2.1 2 0 0 2 2 2 1 Large polyvalent protein associated domain 38 Trypan_PARP PF05887.11 ADV23037.1 - 9.5 6.2 21.0 0.71 9.9 10.1 2.4 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) Ribonuc_L-PSP PF01042.21 ADV23038.1 - 3.4e-33 114.2 0.0 3.9e-33 114.0 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP Gly_transf_sug PF04488.15 ADV23039.1 - 9e-09 35.9 0.0 1.8e-08 34.9 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif CN_hydrolase PF00795.22 ADV23040.1 - 4.7e-32 111.4 0.0 1.1e-31 110.2 0.0 1.5 1 1 0 1 1 1 1 Carbon-nitrogen hydrolase 2OG-FeII_Oxy PF03171.20 ADV23041.1 - 8.3e-24 84.0 0.0 1.7e-23 83.0 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 ADV23041.1 - 5.3e-13 49.8 0.0 8.2e-13 49.1 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal Amidohydro_3 PF07969.11 ADV23042.1 - 2e-05 24.3 0.0 6.4e-05 22.6 0.0 1.8 2 0 0 2 2 2 1 Amidohydrolase family Amidohydro_1 PF01979.20 ADV23042.1 - 0.0016 17.8 0.0 0.1 11.9 0.0 2.7 3 1 0 3 3 3 1 Amidohydrolase family Urease_alpha PF00449.20 ADV23042.1 - 0.0042 17.4 0.1 0.0094 16.3 0.1 1.5 1 0 0 1 1 1 1 Urease alpha-subunit, N-terminal domain Aa_trans PF01490.18 ADV23043.1 - 9e-21 74.0 30.5 1.1e-20 73.8 30.5 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein AA_permease_2 PF13520.6 ADV23043.1 - 0.0028 16.5 41.3 0.0087 14.9 26.4 2.1 1 1 1 2 2 2 2 Amino acid permease Fungal_trans PF04082.18 ADV23044.1 - 0.00072 18.7 0.9 0.0012 17.9 0.9 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Cep3 PF16846.5 ADV23044.1 - 0.06 11.8 0.0 0.099 11.1 0.0 1.2 1 0 0 1 1 1 0 Centromere DNA-binding protein complex CBF3 subunit B Abhydrolase_3 PF07859.13 ADV23045.1 - 6.8e-20 71.8 0.0 1.7e-17 64.0 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 ADV23045.1 - 1.3e-12 47.7 0.1 4.5e-06 26.3 0.0 2.1 2 0 0 2 2 2 2 Prolyl oligopeptidase family DLH PF01738.18 ADV23045.1 - 0.0002 21.0 0.0 0.0066 16.0 0.0 2.2 2 0 0 2 2 2 1 Dienelactone hydrolase family COesterase PF00135.28 ADV23045.1 - 0.00074 18.5 0.0 0.0012 17.8 0.0 1.2 1 0 0 1 1 1 1 Carboxylesterase family DUF2920 PF11144.8 ADV23045.1 - 0.0018 17.5 0.2 0.13 11.4 0.1 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF2920) Abhydrolase_2 PF02230.16 ADV23045.1 - 0.0031 17.4 0.0 0.049 13.4 0.0 2.1 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase AXE1 PF05448.12 ADV23045.1 - 0.0096 14.6 0.0 1.1 7.9 0.0 2.1 2 0 0 2 2 2 2 Acetyl xylan esterase (AXE1) Hydrolase_4 PF12146.8 ADV23045.1 - 0.024 13.9 0.0 0.062 12.6 0.0 1.8 1 1 0 1 1 1 0 Serine aminopeptidase, S33 Say1_Mug180 PF10340.9 ADV23045.1 - 0.17 10.7 0.0 0.22 10.3 0.0 1.2 1 0 0 1 1 1 0 Steryl acetyl hydrolase Esterase PF00756.20 ADV23045.1 - 0.26 10.9 0.4 0.93 9.1 0.0 1.9 2 0 0 2 2 2 0 Putative esterase Gti1_Pac2 PF09729.9 ADV23046.1 - 1.5e-24 87.0 7.4 1.6e-23 83.7 0.2 2.7 2 1 1 3 3 3 2 Gti1/Pac2 family RPAP1_C PF08620.10 ADV23048.1 - 1.3e-22 79.7 0.1 2.6e-22 78.7 0.1 1.6 1 0 0 1 1 1 1 RPAP1-like, C-terminal RPAP1_N PF08621.10 ADV23048.1 - 4.8e-21 74.3 27.0 2.6e-10 39.9 10.8 2.7 2 0 0 2 2 2 2 RPAP1-like, N-terminal DUF2547 PF10818.8 ADV23048.1 - 0.057 14.4 1.6 1.2 10.2 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2547) FtsX_ECD PF18075.1 ADV23048.1 - 0.14 12.8 8.1 0.66 10.6 0.9 2.7 2 0 0 2 2 2 0 FtsX extracellular domain Phage_RpbA PF10789.9 ADV23048.1 - 0.85 9.7 4.9 3.3 7.8 0.3 2.4 2 0 0 2 2 2 0 Phage RNA polymerase binding, RpbA DUF1104 PF06518.11 ADV23048.1 - 0.93 9.9 12.2 0.4 11.1 1.4 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1104) OmpH PF03938.14 ADV23048.1 - 5.7 7.3 13.9 13 6.1 13.9 1.6 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Tugs PF17840.1 ADV23048.1 - 6.3 7.1 9.3 0.44 10.8 0.7 2.8 2 0 0 2 2 2 0 Tethering Ubl4a to BAGS domain UDPGP PF01704.18 ADV23049.1 - 2.6e-48 164.7 0.0 3.5e-48 164.3 0.0 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase NTP_transf_3 PF12804.7 ADV23049.1 - 8.2e-05 23.0 0.1 0.0003 21.2 0.0 2.0 2 0 0 2 2 2 1 MobA-like NTP transferase domain GTP_EFTU PF00009.27 ADV23050.1 - 6.3e-43 146.6 0.0 9.9e-43 145.9 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 ADV23050.1 - 3.4e-30 104.6 0.1 1.4e-29 102.6 0.1 2.2 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 ADV23050.1 - 6.5e-09 36.1 0.1 1.5e-08 34.9 0.1 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 ADV23050.1 - 0.0044 17.1 0.0 0.019 15.1 0.0 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase SOG2 PF10428.9 ADV23050.1 - 0.88 8.7 9.6 1.3 8.2 9.6 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein Trnau1ap PF17654.1 ADV23050.1 - 3.3 8.6 9.8 7.5 7.5 9.8 1.6 1 0 0 1 1 1 0 Selenocysteine tRNA 1 associated proteins MCM PF00493.23 ADV23051.1 - 5.1e-105 349.5 0.0 8.9e-105 348.7 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 ADV23051.1 - 6.7e-33 113.2 0.4 1.3e-32 112.3 0.4 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 ADV23051.1 - 3.1e-22 78.8 1.7 3.1e-22 78.8 1.7 2.3 2 0 0 2 2 2 1 MCM AAA-lid domain MCM_N PF14551.6 ADV23051.1 - 9e-18 64.8 0.4 9e-18 64.8 0.4 2.4 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.21 ADV23051.1 - 8.6e-08 31.8 0.0 1.1e-05 25.0 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 ADV23051.1 - 2.4e-07 30.8 0.0 1.8e-06 28.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) PORR PF11955.8 ADV23051.1 - 0.0093 14.9 0.0 0.015 14.2 0.0 1.3 1 0 0 1 1 1 1 Plant organelle RNA recognition domain AAA_3 PF07726.11 ADV23051.1 - 0.0098 15.8 0.4 0.045 13.6 0.1 2.4 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase_C PF13335.6 ADV23051.1 - 0.013 16.1 1.4 0.04 14.5 0.8 2.3 2 0 0 2 2 1 0 Magnesium chelatase, subunit ChlI C-terminal AAA_lid_2 PF17863.1 ADV23051.1 - 0.027 14.3 0.1 0.1 12.4 0.1 2.0 1 0 0 1 1 1 0 AAA lid domain Sigma54_activat PF00158.26 ADV23051.1 - 0.061 13.0 0.0 0.57 9.9 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain RAI1 PF08652.11 ADV23052.1 - 1.2e-21 76.6 0.0 2.1e-21 75.9 0.0 1.4 1 0 0 1 1 1 1 RAI1 like PD-(D/E)XK nuclease Aminotran_1_2 PF00155.21 ADV23053.1 - 3.5e-21 75.8 0.0 5e-21 75.3 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 ADV23053.1 - 5.5e-07 28.7 0.0 8.2e-07 28.1 0.0 1.2 1 0 0 1 1 1 1 Alanine-glyoxylate amino-transferase GLTSCR1 PF15249.6 ADV23054.1 - 1.3e-19 70.5 0.1 1.3e-19 70.5 0.1 2.2 2 0 0 2 2 2 1 Conserved region of unknown function on GLTSCR protein MCD PF05292.11 ADV23054.1 - 0.37 10.3 1.8 0.57 9.7 1.8 1.2 1 0 0 1 1 1 0 Malonyl-CoA decarboxylase C-terminal domain FapA PF03961.13 ADV23054.1 - 2 6.9 5.2 3.5 6.1 5.2 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A Rrn6 PF10214.9 ADV23054.1 - 2.2 6.7 8.0 2.9 6.3 8.0 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor YabA PF06156.13 ADV23054.1 - 6.9 7.4 6.7 16 6.2 6.7 1.5 1 0 0 1 1 1 0 Initiation control protein YabA DUF4407 PF14362.6 ADV23054.1 - 7.6 5.8 10.4 13 5.1 10.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Chitin_synth_2 PF03142.15 ADV23055.1 - 8.5e-238 790.2 1.3 1.2e-237 789.8 1.3 1.1 1 0 0 1 1 1 1 Chitin synthase Myosin_head PF00063.21 ADV23055.1 - 1.3e-111 374.0 0.0 2.3e-110 369.8 0.0 2.1 1 1 0 1 1 1 1 Myosin head (motor domain) Cyt-b5 PF00173.28 ADV23055.1 - 5.5e-13 48.9 0.0 1.3e-08 34.9 0.0 2.9 3 0 0 3 3 3 2 Cytochrome b5-like Heme/Steroid binding domain DEK_C PF08766.11 ADV23055.1 - 5.6e-13 48.6 1.9 3e-12 46.3 2.3 2.1 2 0 0 2 2 2 1 DEK C terminal domain Glyco_trans_2_3 PF13632.6 ADV23055.1 - 3.9e-10 40.0 4.3 3.9e-10 40.0 4.3 2.5 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 ADV23055.1 - 2.9e-07 30.6 0.0 4.2e-06 26.8 0.0 2.3 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 ADV23055.1 - 1e-05 25.5 0.0 0.071 12.9 0.0 2.5 2 0 0 2 2 2 2 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 ADV23055.1 - 0.0097 15.4 0.1 0.11 12.0 0.0 2.3 2 0 0 2 2 2 1 Glycosyl transferase family 21 T2SSE PF00437.20 ADV23055.1 - 0.15 11.1 0.0 0.37 9.8 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_22 PF13401.6 ADV23055.1 - 0.18 12.1 0.4 1 9.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain UAA PF08449.11 ADV23056.1 - 5.1e-07 29.2 11.2 7.1e-07 28.7 11.2 1.2 1 0 0 1 1 1 1 UAA transporter family Cellulose_synt PF03552.14 ADV23056.1 - 0.068 11.7 3.7 0.09 11.3 3.7 1.1 1 0 0 1 1 1 0 Cellulose synthase Cytochrom_D1 PF02239.16 ADV23057.1 - 0.042 12.4 0.0 1.6 7.2 0.0 2.1 2 0 0 2 2 2 0 Cytochrome D1 heme domain Nop14 PF04147.12 ADV23057.1 - 0.94 7.6 7.0 1.4 7.0 7.0 1.2 1 0 0 1 1 1 0 Nop14-like family S10_plectin PF03501.15 ADV23058.1 - 1.2e-42 143.9 0.1 1.5e-42 143.6 0.1 1.1 1 0 0 1 1 1 1 Plectin/S10 domain DUF4364 PF14277.6 ADV23058.1 - 0.22 11.3 0.0 0.33 10.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4364) DUF1365 PF07103.11 ADV23059.1 - 1.5e-58 198.3 0.0 1.9e-58 198.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1365) Na_H_Exchanger PF00999.21 ADV23060.1 - 8.3e-51 172.9 47.1 8.3e-51 172.9 47.1 1.5 2 0 0 2 2 2 1 Sodium/hydrogen exchanger family zf-HIT PF04438.16 ADV23061.1 - 3.9e-10 39.4 10.7 6.2e-10 38.8 10.7 1.3 1 0 0 1 1 1 1 HIT zinc finger zf-MYND PF01753.18 ADV23061.1 - 0.56 10.3 11.0 1 9.5 11.0 1.4 1 0 0 1 1 1 0 MYND finger Syntaxin-18_N PF10496.9 ADV23062.1 - 0.0045 17.2 0.2 0.15 12.3 0.0 3.3 2 1 0 2 2 2 1 SNARE-complex protein Syntaxin-18 N-terminus SNARE PF05739.19 ADV23062.1 - 0.014 15.4 0.0 0.028 14.4 0.0 1.6 1 0 0 1 1 1 0 SNARE domain DUF4657 PF15552.6 ADV23062.1 - 0.064 12.8 0.1 0.064 12.8 0.1 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4657) TCP PF03634.13 ADV23062.1 - 0.12 12.9 1.4 0.21 12.2 0.3 1.9 2 0 0 2 2 2 0 TCP family transcription factor DUF16 PF01519.16 ADV23062.1 - 0.2 12.2 1.2 7.8 7.1 0.3 2.8 3 0 0 3 3 3 0 Protein of unknown function DUF16 Med4 PF10018.9 ADV23063.1 - 1.5e-17 63.9 0.3 2.5e-17 63.2 0.3 1.3 1 0 0 1 1 1 1 Vitamin-D-receptor interacting Mediator subunit 4 FbpA PF05833.11 ADV23063.1 - 0.037 12.8 0.1 0.048 12.4 0.1 1.1 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) Glyco_H_20C_C PF18088.1 ADV23063.1 - 0.15 11.9 0.7 0.21 11.4 0.7 1.2 1 0 0 1 1 1 0 Glycoside Hydrolase 20C C-terminal domain DUF1664 PF07889.12 ADV23063.1 - 0.23 11.5 0.7 0.38 10.8 0.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Nup188 PF10487.9 ADV23064.1 - 1.6e-38 132.3 0.0 2.2e-29 102.0 0.0 2.3 2 0 0 2 2 2 2 Nucleoporin subcomplex protein binding to Pom34 Cellulase PF00150.18 ADV23065.1 - 2.8e-06 27.0 0.0 6.1e-06 25.9 0.0 1.6 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) MPP6 PF10175.9 ADV23066.1 - 1.5e-07 32.0 3.0 1.5e-07 32.0 3.0 3.2 2 2 0 2 2 2 1 M-phase phosphoprotein 6 Polysacc_deac_1 PF01522.21 ADV23067.1 - 1.7e-30 105.4 0.0 2.9e-30 104.7 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.15 ADV23067.1 - 0.004 16.4 0.0 0.0061 15.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 57 XRN_M PF17846.1 ADV23068.1 - 1.9e-137 458.9 18.4 1.2e-99 334.3 0.0 3.4 2 1 0 3 3 3 2 Xrn1 helical domain XRN_N PF03159.18 ADV23068.1 - 3.5e-99 331.1 0.7 1.4e-98 329.1 0.0 2.1 2 0 0 2 2 2 1 XRN 5'-3' exonuclease N-terminus zf-CCHC PF00098.23 ADV23068.1 - 9.1e-05 22.4 1.9 0.00024 21.0 1.9 1.8 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_3 PF13917.6 ADV23068.1 - 0.059 13.3 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 Zinc knuckle WD40 PF00400.32 ADV23069.1 - 3.9e-35 119.3 0.2 3.8e-06 27.5 0.0 7.0 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV23069.1 - 4.4e-08 33.3 0.0 2.1 8.7 0.0 4.7 2 1 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 ADV23069.1 - 8.8e-05 22.5 0.0 2.4 8.2 0.0 4.1 4 0 0 4 4 4 2 Ciliary BBSome complex subunit 2, middle region PQQ PF01011.21 ADV23069.1 - 0.0028 17.5 0.1 2.2 8.4 0.1 3.2 2 0 0 2 2 2 2 PQQ enzyme repeat PQQ_3 PF13570.6 ADV23069.1 - 0.008 16.6 0.1 3.2 8.3 0.0 3.4 3 0 0 3 3 3 1 PQQ-like domain WD40_like PF17005.5 ADV23069.1 - 0.017 14.5 0.0 0.27 10.5 0.0 2.4 1 1 1 2 2 2 0 WD40-like domain SIKE PF05769.11 ADV23070.1 - 4.8e-09 36.4 8.7 1.5e-06 28.3 3.8 2.6 2 1 0 2 2 2 2 SIKE family TACC_C PF05010.14 ADV23070.1 - 0.026 14.3 0.5 0.026 14.3 0.5 2.3 3 0 0 3 3 3 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal DUF489 PF04356.12 ADV23070.1 - 0.04 13.9 1.1 0.87 9.6 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF489) RseA_C PF03873.13 ADV23070.1 - 0.086 13.1 1.0 0.31 11.3 1.0 1.9 1 0 0 1 1 1 0 Anti sigma-E protein RseA, C-terminal domain DUF2959 PF11172.8 ADV23070.1 - 0.45 10.6 5.2 0.32 11.1 0.9 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2959) SlyX PF04102.12 ADV23070.1 - 2.8 8.6 8.2 9.2 7.0 0.0 4.0 4 0 0 4 4 4 0 SlyX YabA PF06156.13 ADV23070.1 - 2.8 8.6 12.7 2.3 8.9 2.7 3.4 2 1 0 3 3 3 0 Initiation control protein YabA TPR_19 PF14559.6 ADV23071.1 - 4.8e-12 46.2 12.9 9.6e-05 22.8 0.2 5.0 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 ADV23071.1 - 5.6e-09 36.5 11.3 6.9e-07 29.8 0.1 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 ADV23071.1 - 3.8e-08 32.8 0.3 7.3e-05 22.4 0.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 ADV23071.1 - 6.1e-07 29.7 19.3 0.00041 20.9 0.1 6.6 5 3 4 9 9 7 1 Tetratricopeptide repeat TPR_7 PF13176.6 ADV23071.1 - 3.4e-06 26.7 0.9 0.084 12.9 0.0 4.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 ADV23071.1 - 1.8e-05 24.6 6.9 0.0072 16.5 0.0 4.4 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 ADV23071.1 - 7.1e-05 22.9 5.5 1.6 9.3 0.0 5.3 6 1 0 6 6 6 2 Tetratricopeptide repeat TPR_11 PF13414.6 ADV23071.1 - 0.00014 21.4 0.1 0.18 11.5 0.0 3.3 3 0 0 3 3 3 1 TPR repeat TPR_9 PF13371.6 ADV23071.1 - 0.00074 19.6 6.6 0.084 13.0 0.1 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_15 PF13429.6 ADV23071.1 - 0.0013 18.0 0.4 0.033 13.4 0.1 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 ADV23071.1 - 0.0021 18.3 10.4 0.021 15.1 0.1 4.5 4 1 1 5 5 5 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ADV23071.1 - 0.0024 18.1 3.4 0.42 10.9 0.0 4.1 5 0 0 5 5 5 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.17 ADV23071.1 - 0.0027 17.7 10.9 0.0069 16.4 0.0 5.1 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_20 PF14561.6 ADV23071.1 - 0.0048 17.2 9.2 5.4 7.4 0.0 5.5 4 2 1 5 5 5 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ADV23071.1 - 0.014 15.4 0.1 0.28 11.3 0.1 2.8 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 ADV23071.1 - 0.016 15.7 0.2 0.38 11.2 0.0 2.4 2 0 0 2 2 2 0 Alkyl sulfatase dimerisation TPR_10 PF13374.6 ADV23071.1 - 0.21 11.5 1.4 9.8 6.2 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 ADV23071.1 - 0.22 11.1 3.7 1.6 8.4 0.2 3.1 3 1 0 3 3 3 0 Bacterial type III secretion protein (HrpB1_HrpK) MIT PF04212.18 ADV23071.1 - 0.25 11.4 5.0 0.66 10.1 0.1 3.0 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain Symplekin_C PF12295.8 ADV23072.1 - 3.9e-57 193.4 0.3 5.8e-56 189.5 1.0 2.7 3 0 0 3 3 3 1 Symplekin tight junction protein C terminal DUF3453 PF11935.8 ADV23072.1 - 1.7e-34 119.5 0.1 9.3e-34 117.0 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF3453) HEAT_2 PF13646.6 ADV23072.1 - 0.0014 19.0 3.3 0.27 11.7 0.0 4.7 4 0 0 4 4 4 1 HEAT repeats Zn_clus PF00172.18 ADV23073.1 - 7.2e-08 32.4 9.7 1.5e-07 31.4 9.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RINGv PF12906.7 ADV23074.1 - 5.4e-13 48.8 3.8 9.4e-13 48.1 3.8 1.4 1 0 0 1 1 1 1 RING-variant domain zinc_ribbon_4 PF13717.6 ADV23074.1 - 0.012 15.5 0.0 0.023 14.6 0.0 1.4 1 0 0 1 1 1 0 zinc-ribbon domain MRG PF05712.13 ADV23075.1 - 6e-56 188.9 2.8 8.3e-56 188.4 2.8 1.1 1 0 0 1 1 1 1 MRG Tudor-knot PF11717.8 ADV23075.1 - 1.4e-07 31.2 0.2 3.2e-07 30.1 0.2 1.6 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Chromo PF00385.24 ADV23075.1 - 0.01 15.7 0.3 0.026 14.4 0.3 1.7 1 0 0 1 1 1 0 Chromo (CHRromatin Organisation MOdifier) domain DUF5133 PF17196.4 ADV23075.1 - 0.096 12.9 1.9 1.8 8.8 0.5 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF5133) PhoPQ_related PF10142.9 ADV23076.1 - 0.0041 15.8 0.0 0.0058 15.3 0.0 1.1 1 0 0 1 1 1 1 PhoPQ-activated pathogenicity-related protein Abhydrolase_6 PF12697.7 ADV23076.1 - 0.018 15.7 0.0 0.027 15.1 0.0 1.4 1 1 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_5 PF12695.7 ADV23076.1 - 0.029 14.1 0.0 6.3 6.5 0.0 2.5 2 1 0 2 2 2 0 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ADV23076.1 - 0.054 12.8 0.0 12 5.1 0.0 2.6 2 1 1 3 3 3 0 Serine aminopeptidase, S33 DUF3369 PF11849.8 ADV23076.1 - 0.11 12.6 0.0 0.19 11.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3369) DUF1996 PF09362.10 ADV23077.1 - 2.3e-54 184.9 2.9 3.6e-54 184.3 2.9 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) DUF4705 PF15788.5 ADV23077.1 - 1.8 8.9 0.0 1.8 8.9 0.0 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4705) THOC7 PF05615.13 ADV23078.1 - 9.6e-21 74.4 7.5 1.7e-20 73.6 7.5 1.4 1 0 0 1 1 1 1 Tho complex subunit 7 Spc7 PF08317.11 ADV23078.1 - 0.012 14.6 8.4 0.018 13.9 8.4 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein GAS PF13851.6 ADV23078.1 - 0.029 13.7 8.2 0.045 13.1 8.2 1.3 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding RNA_pol_Rpb4 PF03874.16 ADV23078.1 - 0.032 14.6 0.8 0.057 13.7 0.8 1.4 1 0 0 1 1 1 0 RNA polymerase Rpb4 Moulting_cycle PF04870.16 ADV23078.1 - 0.072 12.4 4.1 0.098 11.9 4.1 1.1 1 0 0 1 1 1 0 Moulting cycle SMBP PF16785.5 ADV23078.1 - 0.079 13.2 0.6 0.12 12.6 0.6 1.3 1 0 0 1 1 1 0 Small metal-binding protein SpecificRecomb PF10136.9 ADV23078.1 - 0.16 10.3 3.7 0.4 8.9 3.8 1.5 1 1 0 1 1 1 0 Site-specific recombinase Fib_alpha PF08702.10 ADV23078.1 - 0.25 11.5 4.3 0.44 10.7 4.3 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF4200 PF13863.6 ADV23078.1 - 0.5 10.8 13.0 0.81 10.1 13.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) Med9 PF07544.13 ADV23078.1 - 0.76 9.9 8.1 1.5 9.0 3.5 2.4 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 FUSC PF04632.12 ADV23078.1 - 0.89 8.0 4.4 1.2 7.6 4.4 1.3 1 1 0 1 1 1 0 Fusaric acid resistance protein family IFT57 PF10498.9 ADV23078.1 - 1.4 7.8 9.6 2.6 6.9 9.5 1.4 1 1 0 1 1 1 0 Intra-flagellar transport protein 57 APG6_N PF17675.1 ADV23078.1 - 1.5 9.4 14.6 1.8 9.1 13.6 1.6 1 1 0 1 1 1 0 Apg6 coiled-coil region CENP-H PF05837.12 ADV23078.1 - 4 7.9 10.0 25 5.3 10.0 2.2 1 1 0 1 1 1 0 Centromere protein H (CENP-H) TMF_DNA_bd PF12329.8 ADV23078.1 - 4.7 7.3 12.7 12 5.9 11.2 2.3 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding DivIC PF04977.15 ADV23078.1 - 9.5 6.1 10.9 4.7 7.0 3.7 2.5 1 1 1 2 2 2 0 Septum formation initiator PIG-S PF10510.9 ADV23079.1 - 2.9e-99 333.2 0.7 2e-89 300.8 0.2 2.0 2 0 0 2 2 2 2 Phosphatidylinositol-glycan biosynthesis class S protein WD40 PF00400.32 ADV23081.1 - 1.7e-46 155.2 8.0 1.8e-06 28.5 0.1 9.2 9 0 0 9 9 9 7 WD domain, G-beta repeat F-box-like PF12937.7 ADV23081.1 - 1.7e-11 43.8 0.1 3.9e-11 42.7 0.1 1.7 1 0 0 1 1 1 1 F-box-like Nup160 PF11715.8 ADV23081.1 - 1.3e-10 40.6 3.0 0.083 11.5 0.0 5.3 4 1 1 5 5 5 4 Nucleoporin Nup120/160 F-box PF00646.33 ADV23081.1 - 4e-09 36.1 0.1 1.1e-08 34.7 0.1 1.9 2 0 0 2 2 2 1 F-box domain ANAPC4_WD40 PF12894.7 ADV23081.1 - 1.7e-05 25.0 1.4 5.5 7.4 0.0 5.4 3 2 2 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain F-box_4 PF15966.5 ADV23081.1 - 0.0014 18.5 0.1 0.036 13.9 0.0 2.9 2 0 0 2 2 2 1 F-box Ge1_WD40 PF16529.5 ADV23081.1 - 0.048 12.6 0.8 3 6.7 0.1 3.3 3 1 0 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ PF01011.21 ADV23081.1 - 0.23 11.5 0.9 54 4.0 0.0 3.9 4 0 0 4 4 4 0 PQQ enzyme repeat FeS_assembly_P PF01883.19 ADV23082.1 - 1.2e-14 54.3 0.3 2.1e-14 53.4 0.0 1.6 2 0 0 2 2 2 1 Iron-sulfur cluster assembly protein p450 PF00067.22 ADV23083.1 - 1.2e-66 225.3 0.0 5.2e-66 223.3 0.0 1.8 1 1 0 1 1 1 1 Cytochrome P450 IF4E PF01652.18 ADV23084.1 - 8.4e-47 158.9 0.0 1.2e-46 158.5 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E DUF1754 PF08555.10 ADV23085.1 - 1.2e-17 64.5 9.5 1.2e-17 64.5 9.5 1.8 1 1 1 2 2 2 1 Eukaryotic family of unknown function (DUF1754) GEMIN8 PF15348.6 ADV23085.1 - 0.063 13.6 7.9 0.08 13.2 7.9 1.1 1 0 0 1 1 1 0 Gemini of Cajal bodies-associated protein 8 Spore_coat_CotO PF14153.6 ADV23085.1 - 2.1 8.3 10.7 2.8 7.9 10.7 1.1 1 0 0 1 1 1 0 Spore coat protein CotO DUF4407 PF14362.6 ADV23085.1 - 9.5 5.5 7.4 12 5.1 7.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) UQ_con PF00179.26 ADV23086.1 - 2.9e-21 75.6 0.0 5.6e-21 74.7 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 ADV23086.1 - 0.088 12.7 0.0 0.58 10.0 0.0 2.3 2 0 0 2 2 2 0 UEV domain GP24_25 PF17388.2 ADV23086.1 - 0.13 12.2 0.2 0.5 10.3 0.2 1.9 1 0 0 1 1 1 0 Tail assembly gene products 24 & 25 DNA_pol_phi PF04931.13 ADV23086.1 - 1.7 6.6 7.9 3.3 5.7 7.9 1.3 1 0 0 1 1 1 0 DNA polymerase phi Pyr_redox_2 PF07992.14 ADV23087.1 - 4.2e-52 177.2 0.2 4.9e-52 177.0 0.2 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ADV23087.1 - 3.1e-18 66.1 0.8 8.6e-16 58.3 0.0 3.0 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ADV23087.1 - 3e-17 62.9 0.6 2.9e-14 53.1 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 ADV23087.1 - 2.3e-05 23.8 0.1 0.00016 21.0 0.0 2.3 3 0 0 3 3 3 1 Thi4 family NAD_binding_8 PF13450.6 ADV23087.1 - 4.9e-05 23.5 0.2 0.0051 17.0 0.0 2.6 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 ADV23087.1 - 7.9e-05 22.2 0.1 0.01 15.2 0.0 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.22 ADV23087.1 - 0.00025 20.3 3.7 0.053 12.6 0.1 4.1 4 1 1 5 5 5 1 Glucose inhibited division protein A NAD_binding_7 PF13241.6 ADV23087.1 - 0.0031 17.9 0.2 0.11 12.9 0.0 2.9 2 2 1 3 3 3 1 Putative NAD(P)-binding DAO PF01266.24 ADV23087.1 - 0.0043 16.7 0.7 2.1 7.9 0.2 2.9 3 0 0 3 3 3 1 FAD dependent oxidoreductase K_oxygenase PF13434.6 ADV23087.1 - 0.0052 16.0 2.8 0.8 8.8 0.1 3.9 3 1 1 4 4 4 1 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_2 PF00890.24 ADV23087.1 - 0.0091 15.1 1.5 0.052 12.6 0.1 2.6 1 1 1 3 3 3 1 FAD binding domain FAD_binding_3 PF01494.19 ADV23087.1 - 0.01 15.1 0.7 0.18 11.0 0.1 2.5 2 1 1 3 3 3 0 FAD binding domain ApbA PF02558.16 ADV23087.1 - 0.014 15.1 1.1 0.58 9.8 0.0 2.5 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA Shikimate_DH PF01488.20 ADV23087.1 - 0.014 15.5 0.1 3.6 7.6 0.0 2.9 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 ADV23087.1 - 0.048 14.2 0.0 1.2 9.8 0.0 2.8 3 0 0 3 3 3 0 NADP oxidoreductase coenzyme F420-dependent HI0933_like PF03486.14 ADV23087.1 - 0.053 12.2 0.3 0.28 9.8 0.1 2.2 3 0 0 3 3 3 0 HI0933-like protein Trp_halogenase PF04820.14 ADV23087.1 - 0.12 11.2 0.2 0.56 9.0 0.1 2.1 2 0 0 2 2 2 0 Tryptophan halogenase Heme_oxygenase PF01126.20 ADV23088.1 - 5.3e-32 111.3 0.0 1.3e-15 57.8 0.0 2.4 2 1 0 2 2 2 2 Heme oxygenase NPCBM_assoc PF10633.9 ADV23089.1 - 0.2 11.9 1.5 4.2 7.7 0.1 2.5 2 0 0 2 2 2 0 NPCBM-associated, NEW3 domain of alpha-galactosidase IGR PF09597.10 ADV23090.1 - 9.6e-17 60.8 1.2 5.5e-16 58.4 0.4 2.1 2 0 0 2 2 2 1 IGR protein motif MBOAT PF03062.19 ADV23091.1 - 3.2e-33 115.5 12.9 3.2e-33 115.5 12.9 3.1 2 1 0 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.6 ADV23091.1 - 1.5e-05 25.2 2.0 1.5e-05 25.2 2.0 2.2 2 0 0 2 2 2 1 Membrane bound O-acyl transferase family NfI_DNAbd_pre-N PF10524.9 ADV23091.1 - 0.088 12.7 0.7 0.28 11.1 0.7 1.8 1 0 0 1 1 1 0 Nuclear factor I protein pre-N-terminus Csm1 PF12539.8 ADV23092.1 - 0.0014 19.2 0.1 0.0027 18.3 0.1 1.5 1 0 0 1 1 1 1 Chromosome segregation protein Csm1/Pcs1 STAT_alpha PF01017.20 ADV23092.1 - 0.012 15.5 11.2 0.012 15.5 11.2 2.2 2 0 0 2 2 2 0 STAT protein, all-alpha domain SlyX PF04102.12 ADV23092.1 - 0.017 15.7 14.2 0.29 11.8 1.2 3.6 3 0 0 3 3 3 0 SlyX Filament PF00038.21 ADV23092.1 - 0.047 13.3 24.2 0.028 14.0 14.0 2.3 1 1 1 2 2 2 0 Intermediate filament protein DUF812 PF05667.11 ADV23092.1 - 0.12 11.2 26.3 0.17 10.7 26.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF812) Spc7 PF08317.11 ADV23092.1 - 0.15 10.9 28.0 0.086 11.7 15.2 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein Isochorismatase PF00857.20 ADV23092.1 - 0.3 11.3 2.4 0.98 9.6 0.1 2.6 3 0 0 3 3 3 0 Isochorismatase family Snapin_Pallidin PF14712.6 ADV23092.1 - 0.3 11.5 16.2 1.2 9.6 7.2 2.5 1 1 1 2 2 2 0 Snapin/Pallidin YabA PF06156.13 ADV23092.1 - 0.37 11.5 15.7 0.26 11.9 1.4 3.1 2 1 1 3 3 3 0 Initiation control protein YabA CENP-F_leu_zip PF10473.9 ADV23092.1 - 0.44 10.6 27.8 0.29 11.1 7.3 2.6 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ING PF12998.7 ADV23092.1 - 0.5 11.0 16.4 0.76 10.4 2.1 2.4 2 0 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding Spc24 PF08286.11 ADV23092.1 - 0.71 10.1 18.8 0.15 12.3 1.2 3.5 2 1 0 2 2 2 0 Spc24 subunit of Ndc80 Bap31_Bap29_C PF18035.1 ADV23092.1 - 1.1 9.3 14.9 1.2 9.2 3.3 3.7 2 2 1 3 3 3 0 Bap31/Bap29 cytoplasmic coiled-coil domain DUF4407 PF14362.6 ADV23092.1 - 1.2 8.4 26.3 1.8 7.8 11.2 2.8 1 1 2 3 3 3 0 Domain of unknown function (DUF4407) DivIC PF04977.15 ADV23092.1 - 1.7 8.5 23.2 1 9.1 1.7 3.6 2 1 0 3 3 3 0 Septum formation initiator DUF948 PF06103.11 ADV23092.1 - 1.8 8.9 8.2 12 6.3 0.9 3.3 2 1 2 4 4 3 0 Bacterial protein of unknown function (DUF948) LPP PF04728.13 ADV23092.1 - 2.6 8.5 10.8 8.8 6.8 0.1 4.0 2 1 2 4 4 4 0 Lipoprotein leucine-zipper PGA_cap PF09587.10 ADV23092.1 - 3.8 6.9 5.7 0.72 9.3 0.0 2.1 1 1 1 2 2 2 0 Bacterial capsule synthesis protein PGA_cap NPV_P10 PF05531.12 ADV23092.1 - 6.1 7.4 8.8 15 6.1 0.3 3.0 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein BST2 PF16716.5 ADV23092.1 - 6.9 7.3 16.0 0.89 10.2 2.0 3.2 1 1 2 3 3 3 0 Bone marrow stromal antigen 2 DUF3810 PF12725.7 ADV23093.1 - 0.0077 15.6 1.6 0.042 13.2 0.6 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF3810) ApoLp-III PF07464.11 ADV23093.1 - 0.23 11.5 2.7 1.7 8.7 0.1 2.4 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) DUF948 PF06103.11 ADV23093.1 - 0.35 11.1 4.1 1.7 8.9 1.7 2.9 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) MFS_1 PF07690.16 ADV23094.1 - 2e-21 76.3 40.0 2e-21 76.3 40.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily ARL6IP6 PF15062.6 ADV23094.1 - 0.0048 17.0 1.2 0.0086 16.2 0.1 2.0 2 0 0 2 2 2 1 Haemopoietic lineage transmembrane helix Asp PF00026.23 ADV23095.1 - 1.2e-66 225.3 1.1 1.7e-66 224.8 1.1 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 ADV23095.1 - 6.8e-09 36.2 2.5 3.3e-05 24.2 0.2 2.9 2 1 1 3 3 3 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 ADV23095.1 - 0.0014 19.2 0.3 4.1 8.1 0.0 3.2 3 1 0 3 3 3 2 Aspartyl protease TAXi_C PF14541.6 ADV23095.1 - 0.0089 15.8 0.0 0.079 12.7 0.0 2.1 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal Vir_act_alpha_C PF10400.9 ADV23098.1 - 0.083 13.6 0.1 0.11 13.2 0.1 1.2 1 0 0 1 1 1 0 Virulence activator alpha C-term GxDLY PF14607.6 ADV23098.1 - 0.16 11.7 0.0 0.21 11.4 0.0 1.1 1 0 0 1 1 1 0 N-terminus of Esterase_SGNH_hydro-type F-box-like PF12937.7 ADV23099.1 - 0.0029 17.4 0.4 0.0073 16.2 0.4 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ADV23099.1 - 0.015 15.2 0.3 0.039 13.8 0.3 1.7 1 0 0 1 1 1 0 F-box domain DASH_Hsk3 PF08227.11 ADV23100.1 - 8.8e-15 54.8 2.0 1.4e-14 54.2 2.0 1.3 1 0 0 1 1 1 1 DASH complex subunit Hsk3 like Sec2p PF06428.11 ADV23100.1 - 0.025 14.6 0.6 0.083 12.9 0.1 1.8 1 1 1 2 2 2 0 GDP/GTP exchange factor Sec2p DASH_Spc34 PF08657.10 ADV23100.1 - 0.16 11.8 0.0 0.19 11.5 0.0 1.0 1 0 0 1 1 1 0 DASH complex subunit Spc34 WD40 PF00400.32 ADV23101.1 - 7.5e-13 48.8 11.5 0.005 17.7 0.1 7.2 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV23101.1 - 1.2e-11 44.7 0.0 0.00075 19.8 0.0 3.6 2 1 0 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain DPPIV_N PF00930.21 ADV23101.1 - 0.002 17.0 0.8 0.7 8.6 0.6 3.6 2 1 1 3 3 3 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region PD40 PF07676.12 ADV23101.1 - 0.0032 17.4 1.9 1.3 9.1 0.2 4.1 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat eIF2A PF08662.11 ADV23101.1 - 0.0043 16.9 0.4 0.092 12.6 0.1 2.4 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A Glyco_transf_22 PF03901.17 ADV23102.1 - 4.9e-72 243.4 24.5 1.4e-70 238.7 23.3 2.0 2 0 0 2 2 2 2 Alg9-like mannosyltransferase family VHS PF00790.19 ADV23103.1 - 6.4e-32 110.3 0.0 1.1e-31 109.6 0.0 1.4 1 0 0 1 1 1 1 VHS domain SH3_1 PF00018.28 ADV23103.1 - 4.2e-14 51.9 0.1 8.1e-14 51.0 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 ADV23103.1 - 3.1e-10 39.6 0.2 5.9e-10 38.7 0.2 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 ADV23103.1 - 1.4e-09 37.7 0.1 2.6e-09 36.8 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain GAT PF03127.14 ADV23103.1 - 0.00017 21.8 0.6 0.0016 18.7 0.2 2.6 3 0 0 3 3 3 1 GAT domain UIM PF02809.20 ADV23103.1 - 0.0046 16.8 3.0 0.013 15.4 3.0 1.8 1 0 0 1 1 1 1 Ubiquitin interaction motif Prp18 PF02840.15 ADV23104.1 - 7.9e-58 194.6 0.1 7.9e-58 194.6 0.1 2.4 3 0 0 3 3 3 1 Prp18 domain PRP4 PF08799.11 ADV23104.1 - 6.1e-12 44.9 5.9 1.6e-11 43.6 5.9 1.7 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like DUF2934 PF11154.8 ADV23104.1 - 0.0049 16.5 2.4 2.3 8.0 0.1 2.8 3 0 0 3 3 3 2 Protein of unknown function (DUF2934) Pinin_SDK_memA PF04696.13 ADV23104.1 - 0.026 14.6 21.0 0.44 10.6 12.4 2.5 2 0 0 2 2 2 0 pinin/SDK/memA/ protein conserved region Radial_spoke_3 PF06098.11 ADV23104.1 - 1.4 8.1 15.0 0.018 14.4 6.7 2.1 2 0 0 2 2 2 0 Radial spoke protein 3 Ysc84 PF04366.12 ADV23105.1 - 9.7e-37 125.6 0.3 9.7e-37 125.6 0.3 1.8 2 0 0 2 2 2 1 Las17-binding protein actin regulator SH3_1 PF00018.28 ADV23105.1 - 5.4e-11 41.9 0.0 1.1e-10 40.9 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 ADV23105.1 - 5.3e-09 35.6 0.0 1.2e-08 34.5 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 ADV23105.1 - 9.7e-08 31.8 0.0 2.1e-07 30.7 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain FAM195 PF14799.6 ADV23105.1 - 0.13 12.6 0.2 0.27 11.6 0.2 1.5 1 0 0 1 1 1 0 FAM195 family DUF3104 PF11302.8 ADV23105.1 - 0.2 11.4 0.0 0.48 10.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3104) Ecm33 PF12454.8 ADV23106.1 - 0.033 14.3 0.2 0.033 14.3 0.2 2.5 3 0 0 3 3 3 0 GPI-anchored cell wall organization protein Pardaxin PF07425.11 ADV23106.1 - 0.42 10.2 4.5 2.3 7.9 1.2 3.2 2 0 0 2 2 2 0 Pardaxin AAA_6 PF12774.7 ADV23107.1 - 3.2e-131 437.2 0.0 4.4e-130 433.4 0.0 3.0 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 ADV23107.1 - 5e-116 388.1 6.2 5e-116 388.1 6.2 3.7 4 0 0 4 4 3 1 Dynein heavy chain, N-terminal region 2 DHC_N1 PF08385.12 ADV23107.1 - 9.6e-115 384.3 10.8 9.6e-115 384.3 10.8 3.2 3 1 0 3 3 3 1 Dynein heavy chain, N-terminal region 1 AAA_9 PF12781.7 ADV23107.1 - 1e-72 243.9 0.2 1e-72 243.9 0.2 3.6 4 0 0 4 4 3 1 ATP-binding dynein motor region AAA_8 PF12780.7 ADV23107.1 - 2.9e-66 223.5 0.0 2.2e-65 220.5 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 Dynein_C PF18199.1 ADV23107.1 - 2.1e-50 171.7 0.0 5.4e-50 170.4 0.0 1.7 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain MT PF12777.7 ADV23107.1 - 2.1e-43 148.7 7.6 4.6e-43 147.6 7.6 1.6 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_7 PF12775.7 ADV23107.1 - 3e-42 144.2 0.0 8.2e-37 126.5 0.0 4.5 4 0 0 4 4 4 1 P-loop containing dynein motor region AAA_lid_11 PF18198.1 ADV23107.1 - 2.2e-35 121.9 0.0 4.7e-35 120.8 0.0 1.6 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 ADV23107.1 - 5e-30 104.0 0.0 1.4e-28 99.4 0.0 3.5 3 0 0 3 3 3 1 Dynein heavy chain region D6 P-loop domain AAA_5 PF07728.14 ADV23107.1 - 3.6e-26 91.8 0.0 5.4e-12 45.9 0.0 6.2 5 1 0 5 5 4 3 AAA domain (dynein-related subfamily) Dynein_AAA_lid PF17852.1 ADV23107.1 - 1.4e-13 51.1 0.1 7.4e-13 48.7 0.0 2.5 3 0 0 3 3 1 1 Dynein heavy chain AAA lid domain AAA PF00004.29 ADV23107.1 - 3e-12 47.1 0.0 0.0056 17.1 0.0 5.0 4 0 0 4 4 4 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ADV23107.1 - 2.4e-11 44.1 0.0 0.012 15.9 0.0 5.7 5 0 0 5 5 4 2 AAA domain AAA_33 PF13671.6 ADV23107.1 - 4.1e-09 36.7 0.5 0.21 11.8 0.0 5.8 5 0 0 5 5 5 2 AAA domain AAA_16 PF13191.6 ADV23107.1 - 4.8e-07 30.3 3.0 12 6.3 0.0 7.4 7 0 0 7 7 6 0 AAA ATPase domain AAA_18 PF13238.6 ADV23107.1 - 1.6e-05 25.4 2.1 2 9.0 0.0 5.2 5 0 0 5 5 4 1 AAA domain T2SSE PF00437.20 ADV23107.1 - 4.9e-05 22.5 0.0 0.018 14.1 0.0 3.5 3 0 0 3 3 3 1 Type II/IV secretion system protein Mg_chelatase PF01078.21 ADV23107.1 - 8.1e-05 22.1 0.7 0.95 8.8 0.0 3.5 3 0 0 3 3 3 2 Magnesium chelatase, subunit ChlI ATG16 PF08614.11 ADV23107.1 - 0.0016 18.7 1.5 0.0016 18.7 1.5 4.1 4 0 0 4 4 3 1 Autophagy protein 16 (ATG16) AAA_lid_1 PF17857.1 ADV23107.1 - 0.0019 18.4 0.0 0.0074 16.5 0.0 2.1 1 0 0 1 1 1 1 AAA+ lid domain IstB_IS21 PF01695.17 ADV23107.1 - 0.0029 17.3 0.4 0.49 10.1 0.0 4.1 4 0 0 4 4 4 1 IstB-like ATP binding protein AAA_19 PF13245.6 ADV23107.1 - 0.0036 17.6 4.2 0.34 11.3 0.0 4.6 5 0 0 5 5 4 1 AAA domain FtsK_SpoIIIE PF01580.18 ADV23107.1 - 0.0041 16.5 0.0 9.7 5.5 0.0 3.7 3 0 0 3 3 3 0 FtsK/SpoIIIE family AAA_29 PF13555.6 ADV23107.1 - 0.018 14.8 0.1 18 5.2 0.0 3.5 3 0 0 3 3 3 0 P-loop containing region of AAA domain RNA_helicase PF00910.22 ADV23107.1 - 0.046 14.1 0.0 48 4.4 0.0 4.4 4 0 0 4 4 4 0 RNA helicase AAA_25 PF13481.6 ADV23107.1 - 0.047 13.3 0.5 0.34 10.5 0.0 2.8 3 0 0 3 3 2 0 AAA domain Rad17 PF03215.15 ADV23107.1 - 0.059 13.3 2.4 37 4.2 0.0 4.4 5 0 0 5 5 4 0 Rad17 P-loop domain DEAD PF00270.29 ADV23107.1 - 0.092 12.5 0.0 8.4 6.1 0.0 3.2 2 0 0 2 2 2 0 DEAD/DEAH box helicase RuvB_N PF05496.12 ADV23107.1 - 0.15 11.8 0.1 6.2 6.6 0.0 3.4 4 0 0 4 4 4 0 Holliday junction DNA helicase RuvB P-loop domain TMF_DNA_bd PF12329.8 ADV23107.1 - 0.31 11.1 23.8 0.79 9.8 2.6 3.8 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding PXA PF02194.15 ADV23107.1 - 0.37 10.7 2.8 46 3.9 4.3 3.5 2 0 0 2 2 2 0 PXA domain ERM PF00769.19 ADV23107.1 - 0.69 9.7 25.7 1.9 8.2 6.9 2.8 2 0 0 2 2 2 0 Ezrin/radixin/moesin family BRE1 PF08647.11 ADV23107.1 - 1.4 9.0 24.0 0.042 13.9 5.9 4.1 2 1 1 3 3 3 0 BRE1 E3 ubiquitin ligase YabA PF06156.13 ADV23107.1 - 2.1 9.0 18.3 40 4.9 1.4 5.1 4 0 0 4 4 3 0 Initiation control protein YabA DUF4407 PF14362.6 ADV23107.1 - 3.9 6.7 21.5 0.34 10.2 0.9 3.5 4 0 0 4 4 3 0 Domain of unknown function (DUF4407) Taxilin PF09728.9 ADV23107.1 - 4 6.5 25.9 0.037 13.2 3.0 3.7 3 0 0 3 3 3 0 Myosin-like coiled-coil protein Phage_GP20 PF06810.11 ADV23107.1 - 4.3 7.1 18.4 0.48 10.2 6.2 3.9 3 0 0 3 3 3 0 Phage minor structural protein GP20 Cyclin_N PF00134.23 ADV23109.1 - 1e-09 38.2 0.0 2.2e-09 37.1 0.0 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain DUF2525 PF10733.9 ADV23109.1 - 0.11 12.8 0.1 0.3 11.4 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2525) Ribosomal_S11 PF00411.19 ADV23110.1 - 2.1e-46 156.8 1.6 2.7e-46 156.5 1.6 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 HAD_2 PF13419.6 ADV23111.1 - 3.1e-09 37.1 0.0 5.1e-09 36.5 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ADV23111.1 - 1e-06 29.2 0.0 1.3e-06 28.8 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ADV23111.1 - 0.082 13.0 0.0 0.17 12.0 0.0 1.6 1 0 0 1 1 1 0 HAD-hyrolase-like Sugar_tr PF00083.24 ADV23113.1 - 2.1e-89 300.5 21.7 2.7e-89 300.1 21.7 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ADV23113.1 - 1.6e-19 70.1 34.3 4.7e-14 52.1 12.8 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Alpha-amylase PF00128.24 ADV23114.1 - 1.4e-68 231.9 0.0 5.7e-68 229.9 0.0 1.9 1 1 0 1 1 1 1 Alpha amylase, catalytic domain DUF3459 PF11941.8 ADV23114.1 - 0.017 15.4 0.1 0.047 14.0 0.1 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF3459) Glyoxalase_6 PF18029.1 ADV23114.1 - 0.086 13.6 0.1 16 6.3 0.0 2.9 2 1 0 2 2 2 0 Glyoxalase-like domain Cytochrom_C1 PF02167.15 ADV23116.1 - 2.5e-97 324.9 0.0 4e-97 324.2 0.0 1.2 1 0 0 1 1 1 1 Cytochrome C1 family Cytochrome_CBB3 PF13442.6 ADV23116.1 - 0.00088 19.6 0.0 0.0018 18.6 0.0 1.6 1 0 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C PF00034.21 ADV23116.1 - 0.011 16.8 0.1 0.048 14.8 0.1 2.1 2 1 0 2 2 2 0 Cytochrome c CPSase_L_D2 PF02786.17 ADV23117.1 - 4.8e-82 274.6 0.2 8.1e-82 273.8 0.2 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain PYC_OADA PF02436.18 ADV23117.1 - 9.8e-69 231.1 0.0 1.5e-68 230.4 0.0 1.3 1 0 0 1 1 1 1 Conserved carboxylase domain Biotin_carb_N PF00289.22 ADV23117.1 - 9.7e-39 132.3 0.0 2e-38 131.3 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 ADV23117.1 - 9.6e-30 102.9 0.0 2e-29 101.8 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain HMGL-like PF00682.19 ADV23117.1 - 1.9e-25 89.9 0.0 4.4e-25 88.7 0.0 1.6 1 0 0 1 1 1 1 HMGL-like Dala_Dala_lig_C PF07478.13 ADV23117.1 - 1.8e-10 40.7 0.0 4.1e-10 39.5 0.0 1.5 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 ADV23117.1 - 6.2e-08 32.4 0.0 1.4e-07 31.2 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain RimK PF08443.11 ADV23117.1 - 5.3e-06 26.1 0.0 0.0001 21.9 0.0 2.7 1 1 0 1 1 1 1 RimK-like ATP-grasp domain ATP-grasp_3 PF02655.14 ADV23117.1 - 7.6e-06 26.1 0.0 2.5e-05 24.4 0.0 1.9 1 1 1 2 2 2 1 ATP-grasp domain GARS_A PF01071.19 ADV23117.1 - 0.00092 19.0 0.0 0.0021 17.9 0.0 1.7 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATPgrasp_ST PF14397.6 ADV23117.1 - 0.0028 17.0 0.0 0.0072 15.6 0.0 1.6 1 0 0 1 1 1 1 Sugar-transfer associated ATP-grasp ATP-grasp_4 PF13535.6 ADV23117.1 - 0.0044 16.6 0.0 0.0085 15.7 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_Ter PF15632.6 ADV23117.1 - 0.18 11.6 0.9 0.5 10.1 0.1 2.1 2 0 0 2 2 2 0 ATP-grasp in the biosynthetic pathway with Ter operon TFIIB PF00382.19 ADV23118.1 - 1.6e-28 98.6 0.0 4.4e-15 55.5 0.0 2.4 2 0 0 2 2 2 2 Transcription factor TFIIB repeat BRF1 PF07741.13 ADV23118.1 - 2.1e-19 69.7 1.0 2.1e-19 69.7 1.0 3.6 5 1 0 5 5 5 1 Brf1-like TBP-binding domain TF_Zn_Ribbon PF08271.12 ADV23118.1 - 1.7e-07 30.6 0.3 4.9e-07 29.2 0.3 1.9 1 0 0 1 1 1 1 TFIIB zinc-binding RB_B PF01857.20 ADV23118.1 - 0.085 12.9 0.1 0.22 11.5 0.1 1.6 1 0 0 1 1 1 0 Retinoblastoma-associated protein B domain SR1P PF13790.6 ADV23118.1 - 0.28 11.3 0.8 0.75 10.0 0.8 1.8 1 0 0 1 1 1 0 SR1 protein PQ-loop PF04193.14 ADV23119.1 - 1.1e-19 69.9 16.8 4.6e-11 42.3 0.4 3.0 3 0 0 3 3 3 2 PQ loop repeat DUF4149 PF13664.6 ADV23119.1 - 0.74 10.2 12.4 1.5 9.2 0.1 3.6 4 0 0 4 4 4 0 Domain of unknown function (DUF4149) DUF2070 PF09843.9 ADV23119.1 - 2.9 6.1 13.8 0.11 10.8 3.9 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2070) Clat_adaptor_s PF01217.20 ADV23120.1 - 7.6e-47 158.8 0.1 2.9e-45 153.7 0.1 2.0 1 1 0 1 1 1 1 Clathrin adaptor complex small chain HGTP_anticodon PF03129.20 ADV23121.1 - 3.5e-18 65.5 0.0 1.1e-17 64.0 0.0 1.9 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 ADV23121.1 - 1e-07 32.1 0.0 2.9e-07 30.6 0.0 1.9 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Ferlin_C PF16165.5 ADV23121.1 - 3.7 7.5 4.8 8.2 6.4 4.8 1.5 1 0 0 1 1 1 0 Ferlin C-terminus P5CR_dimer PF14748.6 ADV23122.1 - 5.1e-38 129.5 2.3 9.3e-38 128.6 2.3 1.5 1 0 0 1 1 1 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 ADV23122.1 - 7.4e-11 42.5 0.0 1e-07 32.5 0.0 2.5 2 0 0 2 2 2 2 NADP oxidoreductase coenzyme F420-dependent PDH PF02153.17 ADV23122.1 - 0.022 13.8 0.0 0.12 11.3 0.0 1.9 1 1 0 1 1 1 0 Prephenate dehydrogenase DUF499 PF04465.12 ADV23122.1 - 0.33 8.6 0.0 0.44 8.2 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF499) NAD_binding_7 PF13241.6 ADV23123.1 - 7.1e-27 93.9 0.0 1.1e-26 93.3 0.0 1.3 1 0 0 1 1 1 1 Putative NAD(P)-binding Sirohm_synth_C PF14823.6 ADV23123.1 - 6.5e-19 67.3 0.1 1.2e-18 66.5 0.1 1.4 1 0 0 1 1 1 1 Sirohaem biosynthesis protein C-terminal Sirohm_synth_M PF14824.6 ADV23123.1 - 1.3e-09 37.3 0.2 2.6e-09 36.4 0.2 1.6 1 0 0 1 1 1 1 Sirohaem biosynthesis protein central ThiF PF00899.21 ADV23124.1 - 7.3e-67 225.3 0.0 1e-66 224.8 0.0 1.1 1 0 0 1 1 1 1 ThiF family UBA_e1_thiolCys PF10585.9 ADV23124.1 - 2.1e-14 54.0 0.0 1.1e-10 41.9 0.0 2.4 2 0 0 2 2 2 2 Ubiquitin-activating enzyme active site UAE_UbL PF14732.6 ADV23124.1 - 2.5e-09 37.6 0.0 8.9e-09 35.8 0.0 2.0 1 0 0 1 1 1 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain NAD_binding_7 PF13241.6 ADV23124.1 - 0.00025 21.4 0.0 0.00076 19.9 0.0 1.8 1 1 0 1 1 1 1 Putative NAD(P)-binding Pyr_redox PF00070.27 ADV23124.1 - 0.048 14.2 0.1 0.59 10.7 0.1 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Sacchrp_dh_NADP PF03435.18 ADV23124.1 - 0.089 13.1 0.1 0.43 10.8 0.1 2.1 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 ADV23124.1 - 0.1 12.6 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase CPSF_A PF03178.15 ADV23125.1 - 2.4e-89 299.8 0.0 1.3e-88 297.4 0.0 2.1 3 0 0 3 3 3 1 CPSF A subunit region MMS1_N PF10433.9 ADV23125.1 - 3.7e-21 75.3 0.0 8.9e-21 74.1 0.0 1.6 2 0 0 2 2 2 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term His_Phos_1 PF00300.22 ADV23126.1 - 4.9e-39 134.0 0.0 1.3e-38 132.7 0.0 1.6 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) DUF2786 PF10979.8 ADV23126.1 - 0.022 14.7 0.1 0.033 14.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2786) G-gamma PF00631.22 ADV23128.1 - 2.1e-24 85.3 0.0 2.5e-24 85.0 0.0 1.1 1 0 0 1 1 1 1 GGL domain SARAF PF06682.12 ADV23129.1 - 3.8 7.1 8.5 4.1 7.0 8.5 1.0 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis UQ_con PF00179.26 ADV23130.1 - 6.5e-18 64.7 0.0 7e-18 64.6 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 ADV23130.1 - 0.071 13.4 0.0 0.074 13.3 0.0 1.2 1 0 0 1 1 1 0 RWD domain HEAT_EZ PF13513.6 ADV23132.1 - 1.4e-20 73.4 6.9 2.4e-07 31.1 0.0 10.6 9 2 2 11 11 10 3 HEAT-like repeat HEAT_2 PF13646.6 ADV23132.1 - 5.3e-19 68.4 3.3 4.4e-05 23.8 0.1 9.0 5 3 5 10 10 10 5 HEAT repeats HEAT PF02985.22 ADV23132.1 - 1.3e-17 62.4 9.0 0.0058 16.8 0.0 12.4 13 0 0 13 13 13 2 HEAT repeat Vac14_Fab1_bd PF12755.7 ADV23132.1 - 1.6e-10 41.4 0.0 1.6 9.4 0.0 7.2 7 2 1 8 8 8 3 Vacuolar 14 Fab1-binding region IBN_N PF03810.19 ADV23132.1 - 1.5e-08 34.5 0.1 1.2e-07 31.5 0.1 2.7 3 0 0 3 3 3 1 Importin-beta N-terminal domain Cnd1 PF12717.7 ADV23132.1 - 2.2e-08 34.3 0.1 0.018 15.1 0.0 4.4 3 2 1 4 4 4 2 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 ADV23132.1 - 2.2e-07 29.9 0.8 0.046 12.3 0.1 4.4 5 0 0 5 5 5 2 Adaptin N terminal region Arm PF00514.23 ADV23132.1 - 7.3e-06 25.8 0.8 6.4 7.0 0.0 7.9 10 0 0 10 10 9 1 Armadillo/beta-catenin-like repeat CLASP_N PF12348.8 ADV23132.1 - 1.1e-05 25.2 0.0 0.092 12.3 0.0 4.7 4 1 1 5 5 5 1 CLASP N terminal MMS19_C PF12460.8 ADV23132.1 - 0.0018 17.4 0.1 0.22 10.6 0.1 3.8 4 0 0 4 4 4 1 RNAPII transcription regulator C-terminal UME PF08064.13 ADV23132.1 - 0.0029 17.5 0.4 11 6.0 0.0 5.2 6 1 0 6 6 6 1 UME (NUC010) domain Xpo1 PF08389.12 ADV23132.1 - 0.0064 16.6 0.5 8.8 6.4 0.0 3.9 4 0 0 4 4 4 1 Exportin 1-like protein NUC173 PF08161.12 ADV23132.1 - 0.047 13.3 0.0 63 3.1 0.0 4.3 4 0 0 4 4 4 0 NUC173 domain MOR2-PAG1_C PF14225.6 ADV23132.1 - 0.091 12.6 0.1 0.84 9.5 0.1 2.7 3 0 0 3 3 3 0 Cell morphogenesis C-terminal MAGE PF01454.19 ADV23133.1 - 6.7e-55 186.1 0.0 1.1e-53 182.2 0.0 2.5 1 1 0 1 1 1 1 MAGE family CBFD_NFYB_HMF PF00808.23 ADV23133.1 - 8e-20 70.9 1.0 1.5e-19 70.1 1.0 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 ADV23133.1 - 3e-15 56.7 0.1 3e-15 56.7 0.1 3.4 4 0 0 4 4 4 1 Core histone H2A/H2B/H3/H4 Myc_N PF01056.18 ADV23133.1 - 0.051 13.5 7.1 0.4 10.5 0.6 2.3 2 0 0 2 2 2 0 Myc amino-terminal region TAFII28 PF04719.14 ADV23133.1 - 0.11 12.5 0.5 0.3 11.2 0.0 1.9 2 0 0 2 2 2 0 hTAFII28-like protein conserved region TLP-20 PF06088.11 ADV23133.1 - 0.18 11.7 3.1 9 6.2 0.5 2.6 2 0 0 2 2 2 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) Zip PF02535.22 ADV23133.1 - 0.28 10.4 2.0 10 5.2 0.0 2.2 2 0 0 2 2 2 0 ZIP Zinc transporter CENP-X PF09415.10 ADV23133.1 - 0.35 11.2 2.3 0.41 11.0 0.1 2.2 2 0 0 2 2 2 0 CENP-S associating Centromere protein X DUF913 PF06025.12 ADV23133.1 - 0.89 8.5 2.5 2.8 6.8 0.2 2.3 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) DUF4662 PF15578.6 ADV23133.1 - 1.2 8.9 4.0 0.4 10.4 0.8 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4662) DUF3128 PF11326.8 ADV23134.1 - 3e-24 85.2 1.0 3e-24 85.2 1.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3128) GAGA PF09237.11 ADV23134.1 - 0.17 11.7 0.2 0.17 11.7 0.2 1.8 2 0 0 2 2 2 0 GAGA factor MAT1 PF06391.13 ADV23135.1 - 2e-38 132.3 18.7 2.7e-38 131.8 18.7 1.1 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 zf-C3HC4_5 PF17121.5 ADV23135.1 - 1.8e-19 69.3 7.4 3e-19 68.6 7.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ADV23135.1 - 1.2e-05 25.1 6.2 2e-05 24.3 6.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ADV23135.1 - 1.4e-05 25.0 7.7 3.5e-05 23.7 7.7 1.7 1 1 1 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.6 ADV23135.1 - 2.7e-05 24.4 8.3 4.3e-05 23.7 8.3 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 ADV23135.1 - 5.8e-05 22.9 9.3 0.0001 22.1 9.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ADV23135.1 - 0.0033 17.2 11.5 0.011 15.6 11.6 1.8 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ADV23135.1 - 0.0049 16.7 9.1 0.39 10.6 9.7 2.3 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-FPG_IleRS PF06827.14 ADV23135.1 - 0.022 14.6 2.0 0.025 14.5 0.1 2.1 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS zf-UDP PF14569.6 ADV23135.1 - 0.13 12.4 2.6 0.28 11.3 2.6 1.5 1 0 0 1 1 1 0 Zinc-binding RING-finger TraT PF05818.12 ADV23135.1 - 0.15 11.7 0.8 0.24 11.0 0.8 1.2 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein zf-RING_4 PF14570.6 ADV23135.1 - 0.18 11.6 7.7 0.63 9.9 8.0 1.7 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain DZR PF12773.7 ADV23135.1 - 0.34 11.0 5.3 1.3 9.2 5.3 1.9 1 1 0 1 1 1 0 Double zinc ribbon zf-RING_UBOX PF13445.6 ADV23135.1 - 0.8 9.8 9.0 1.6 8.8 9.0 1.5 1 0 0 1 1 1 0 RING-type zinc-finger DUF4375 PF14300.6 ADV23135.1 - 3.4 7.9 6.3 4.1 7.7 0.1 2.5 1 1 0 2 2 2 0 Domain of unknown function (DUF4375) Zn-ribbon_8 PF09723.10 ADV23135.1 - 3.8 7.7 6.9 21 5.4 3.0 2.7 2 0 0 2 2 2 0 Zinc ribbon domain Cyto_heme_lyase PF01265.17 ADV23136.1 - 3e-81 273.2 3.3 1.5e-79 267.6 3.3 2.0 1 1 0 1 1 1 1 Cytochrome c/c1 heme lyase Asp PF00026.23 ADV23137.1 - 1.4e-70 238.2 10.9 1.8e-70 237.9 10.9 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 ADV23137.1 - 5.7e-12 46.2 6.3 2.7e-07 31.0 0.1 3.3 2 1 1 3 3 3 2 Xylanase inhibitor N-terminal DUF1604 PF07713.13 ADV23138.1 - 0.06 13.2 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1604) CstA PF02554.14 ADV23138.1 - 0.38 9.6 1.1 0.5 9.2 1.1 1.1 1 0 0 1 1 1 0 Carbon starvation protein CstA Proteasome PF00227.26 ADV23139.1 - 4.2e-34 117.7 0.0 7.3e-34 116.9 0.0 1.3 2 0 0 2 2 2 1 Proteasome subunit Rad10 PF03834.14 ADV23141.1 - 3.5e-41 139.8 0.5 4.9e-41 139.3 0.5 1.2 1 0 0 1 1 1 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) HHH_2 PF12826.7 ADV23141.1 - 1.3e-05 25.2 0.2 0.00012 22.1 0.0 2.4 2 0 0 2 2 2 1 Helix-hairpin-helix motif HHH_5 PF14520.6 ADV23141.1 - 0.0018 18.9 0.0 0.0042 17.6 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix domain DUF1365 PF07103.11 ADV23141.1 - 0.08 12.6 0.4 0.11 12.1 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1365) Forkhead PF00250.18 ADV23143.1 - 4.8e-18 65.2 0.0 1.3e-17 63.8 0.0 1.8 2 0 0 2 2 2 1 Forkhead domain NCE101 PF11654.8 ADV23144.1 - 3.5e-21 74.6 0.0 5e-21 74.1 0.0 1.2 1 0 0 1 1 1 1 Non-classical export protein 1 TFIIS_M PF07500.14 ADV23145.1 - 4e-24 85.2 0.7 4e-24 85.2 0.7 2.0 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain Med26 PF08711.11 ADV23145.1 - 2.3e-12 46.7 0.5 5e-12 45.6 0.5 1.6 1 0 0 1 1 1 1 TFIIS helical bundle-like domain TFIIS_C PF01096.18 ADV23145.1 - 5.9e-12 45.2 2.8 1.1e-11 44.4 2.8 1.4 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) DUF5578 PF17741.1 ADV23145.1 - 0.076 12.4 0.1 0.16 11.4 0.0 1.5 2 0 0 2 2 2 0 Family of unknown function (DUF5578) CAF1-p150_C2 PF15539.6 ADV23146.1 - 1.6 8.2 6.8 0.69 9.3 4.4 1.5 2 0 0 2 2 2 0 CAF1 complex subunit p150, region binding to CAF1-p60 at C-term SPX PF03105.19 ADV23146.1 - 3.2 7.6 10.2 5.4 6.8 10.2 1.3 1 0 0 1 1 1 0 SPX domain Vps39_2 PF10367.9 ADV23146.1 - 4.9 7.6 8.9 12 6.4 0.1 3.1 3 0 0 3 3 3 0 Vacuolar sorting protein 39 domain 2 CKS PF01111.19 ADV23147.1 - 1.8e-28 98.6 0.8 2.3e-28 98.2 0.0 1.6 2 0 0 2 2 2 1 Cyclin-dependent kinase regulatory subunit MBOAT PF03062.19 ADV23148.1 - 5.8e-54 183.7 16.2 9.6e-54 183.0 16.2 1.3 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family DEAD PF00270.29 ADV23149.1 - 9.4e-51 172.1 0.0 2.5e-50 170.7 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ADV23149.1 - 1.5e-30 105.8 0.0 1.3e-29 102.8 0.0 2.3 1 1 1 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ADV23149.1 - 4e-06 26.9 0.0 1.1e-05 25.5 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit UTP25 PF06862.12 ADV23149.1 - 0.00094 18.1 0.0 0.03 13.1 0.0 2.2 2 0 0 2 2 2 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 DUF2443 PF10398.9 ADV23149.1 - 0.075 13.1 0.1 0.32 11.1 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2443) RRM_1 PF00076.22 ADV23150.1 - 1.1e-27 95.6 1.4 7.7e-12 44.9 0.0 5.3 4 1 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ADV23150.1 - 1.8e-05 24.5 0.0 0.014 15.3 0.0 3.2 3 0 0 3 3 3 1 Occluded RNA-recognition motif RRM_7 PF16367.5 ADV23150.1 - 4e-05 23.7 0.0 0.07 13.3 0.0 3.2 3 0 0 3 3 3 2 RNA recognition motif NPR3 PF03666.13 ADV23153.1 - 7.4e-113 377.8 0.3 3.2e-112 375.7 0.0 1.9 2 0 0 2 2 2 1 Nitrogen Permease regulator of amino acid transport activity 3 DUF4050 PF13259.6 ADV23153.1 - 4.2 7.6 7.0 0.34 11.2 0.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF4050) LRR_9 PF14580.6 ADV23154.1 - 2.9e-39 134.3 0.1 3.9e-39 134.0 0.1 1.1 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 ADV23154.1 - 1.9e-09 37.7 17.2 2.4e-05 24.6 0.7 3.7 2 2 2 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ADV23154.1 - 3.5e-06 26.7 8.2 5.7e-06 26.0 1.7 2.6 1 1 1 2 2 2 2 Leucine rich repeat Paramyx_P_V_C PF03210.13 ADV23154.1 - 0.13 12.1 0.1 0.25 11.1 0.1 1.5 1 0 0 1 1 1 0 Paramyxovirus P/V phosphoprotein C-terminal LRR_6 PF13516.6 ADV23154.1 - 0.31 11.2 6.6 5.1 7.4 0.1 3.9 4 0 0 4 4 4 0 Leucine Rich repeat LRR_1 PF00560.33 ADV23154.1 - 8.5 7.4 0.0 8.5 7.4 0.0 4.6 6 1 0 6 6 6 0 Leucine Rich Repeat ATP11 PF06644.11 ADV23155.1 - 1.9e-71 241.1 0.5 2.3e-71 240.8 0.5 1.1 1 0 0 1 1 1 1 ATP11 protein Pox_Ag35 PF03286.14 ADV23156.1 - 0.4 10.4 3.1 0.63 9.8 3.1 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DUF443 PF04276.12 ADV23157.1 - 0.12 12.2 0.4 0.15 11.8 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF443) CLN3 PF02487.17 ADV23160.1 - 7.5e-114 380.9 0.0 1e-113 380.4 0.0 1.2 1 0 0 1 1 1 1 CLN3 protein Pro_isomerase PF00160.21 ADV23161.1 - 1.9e-40 138.7 0.0 3.7e-40 137.8 0.0 1.5 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_2 PF07719.17 ADV23161.1 - 9e-05 22.3 3.4 0.19 11.9 0.3 2.7 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 ADV23161.1 - 0.3 11.8 2.6 3 8.6 0.0 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 ADV23161.1 - 0.68 9.9 3.1 9.5 6.2 0.2 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat Translin PF01997.16 ADV23162.1 - 3.7e-58 196.9 0.0 4.5e-58 196.6 0.0 1.1 1 0 0 1 1 1 1 Translin family CENP-H PF05837.12 ADV23162.1 - 2.8 8.4 6.1 3.9 7.9 1.9 2.2 2 0 0 2 2 2 0 Centromere protein H (CENP-H) ADK PF00406.22 ADV23163.1 - 1.2e-43 148.8 0.0 2.6e-43 147.7 0.0 1.5 1 1 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 ADV23163.1 - 4.4e-32 111.4 0.0 7.2e-32 110.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ADV23163.1 - 3.6e-08 34.0 0.0 6.2e-08 33.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 ADV23163.1 - 2.7e-05 23.9 0.6 0.16 11.6 0.0 2.3 2 0 0 2 2 2 2 Thymidylate kinase AAA_33 PF13671.6 ADV23163.1 - 0.00041 20.5 0.1 0.0078 16.4 0.1 2.2 1 1 0 1 1 1 1 AAA domain NTPase_1 PF03266.15 ADV23163.1 - 0.092 12.7 1.0 0.67 9.8 0.1 2.4 2 1 1 3 3 3 0 NTPase zf-C2H2 PF00096.26 ADV23164.1 - 0.078 13.5 0.3 0.2 12.1 0.3 1.8 1 0 0 1 1 1 0 Zinc finger, C2H2 type TIMELESS PF04821.14 ADV23165.1 - 1.6e-66 224.4 2.0 3e-66 223.5 0.2 2.3 2 0 0 2 2 2 1 Timeless protein MA3 PF02847.17 ADV23167.1 - 2.6e-28 98.2 0.0 5.4e-28 97.2 0.0 1.6 1 0 0 1 1 1 1 MA3 domain MIF4G PF02854.19 ADV23167.1 - 9.9e-11 41.7 1.5 2.8e-10 40.2 0.4 2.1 2 0 0 2 2 2 1 MIF4G domain IMUP PF15761.5 ADV23167.1 - 1.3 9.7 15.8 0.15 12.7 9.9 2.4 2 0 0 2 2 2 0 Immortalisation up-regulated protein UBA_4 PF14555.6 ADV23168.1 - 0.0053 16.5 0.6 0.022 14.6 0.6 2.0 2 0 0 2 2 2 1 UBA-like domain Rrn6 PF10214.9 ADV23168.1 - 0.03 12.8 3.6 0.041 12.4 3.6 1.2 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor DUF1682 PF07946.14 ADV23168.1 - 0.077 12.2 5.5 0.12 11.6 5.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) SUB1_ProdP9 PF18213.1 ADV23168.1 - 0.16 11.8 0.0 0.32 10.9 0.0 1.4 1 0 0 1 1 1 0 SUB1 protease Prodomain ProdP9 GDA1_CD39 PF01150.17 ADV23169.1 - 2.2e-84 283.6 0.0 4.5e-76 256.2 0.0 2.3 2 0 0 2 2 2 2 GDA1/CD39 (nucleoside phosphatase) family PH_10 PF15411.6 ADV23171.1 - 8.1e-24 84.2 0.1 1.6e-23 83.2 0.1 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain zf-RING_2 PF13639.6 ADV23171.1 - 6.4e-05 23.2 1.7 0.00016 21.9 1.7 1.8 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 ADV23171.1 - 0.00074 19.4 0.9 0.0014 18.5 0.9 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 ADV23171.1 - 0.0063 16.5 1.8 0.0063 16.5 1.8 2.0 2 0 0 2 2 2 1 RING-type zinc-finger VWA PF00092.28 ADV23171.1 - 0.038 14.2 0.0 0.087 13.1 0.0 1.6 1 0 0 1 1 1 0 von Willebrand factor type A domain zf-RING_2 PF13639.6 ADV23172.1 - 5.8e-07 29.7 5.3 2e-06 28.1 5.3 1.9 1 1 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 ADV23172.1 - 5.3e-06 26.6 1.5 5.3e-06 26.6 1.5 1.9 2 0 0 2 2 1 1 RING-H2 zinc finger domain FANCL_C PF11793.8 ADV23172.1 - 3.1e-05 24.0 1.3 3.1e-05 24.0 1.3 1.7 2 0 0 2 2 1 1 FANCL C-terminal domain zf-C3HC4 PF00097.25 ADV23172.1 - 4.6e-05 23.2 2.4 0.00017 21.4 2.4 2.0 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ADV23172.1 - 5.8e-05 23.0 1.2 5.8e-05 23.0 1.2 2.0 2 0 0 2 2 2 1 RING-type zinc-finger Phage_GP20 PF06810.11 ADV23172.1 - 0.0014 18.5 9.7 0.0014 18.5 9.7 2.5 1 1 0 2 2 2 1 Phage minor structural protein GP20 Zn_ribbon_17 PF17120.5 ADV23172.1 - 0.0019 17.8 0.3 0.0048 16.5 0.3 1.6 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-RING_11 PF17123.5 ADV23172.1 - 0.0036 17.0 5.2 0.0085 15.8 5.2 1.7 1 1 0 1 1 1 1 RING-like zinc finger zf-RING_5 PF14634.6 ADV23172.1 - 0.004 17.1 0.9 0.011 15.7 0.9 1.7 1 1 0 1 1 1 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 ADV23172.1 - 0.0057 16.7 0.2 0.015 15.3 0.2 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.6 ADV23172.1 - 0.0059 16.4 4.4 0.0059 16.4 4.4 2.8 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) RINGv PF12906.7 ADV23172.1 - 0.04 14.0 0.9 0.09 12.9 0.9 1.6 1 0 0 1 1 1 0 RING-variant domain CENP-H PF05837.12 ADV23172.1 - 0.1 13.0 0.1 0.1 13.0 0.1 3.6 2 1 1 3 3 1 0 Centromere protein H (CENP-H) DAGK_cat PF00781.24 ADV23173.1 - 2e-15 56.5 0.0 5.1e-15 55.2 0.0 1.7 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Ras PF00071.22 ADV23174.1 - 8.2e-51 171.8 0.0 9.4e-51 171.6 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ADV23174.1 - 2.6e-19 69.6 0.0 3.6e-19 69.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ADV23174.1 - 3.3e-06 26.7 0.0 5.9e-06 25.9 0.0 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family Pkinase PF00069.25 ADV23175.1 - 4.9e-69 232.6 0.0 6.5e-69 232.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV23175.1 - 8.8e-47 159.6 0.0 1.3e-46 158.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 ADV23175.1 - 1.5e-20 73.3 0.1 3.9e-20 71.9 0.1 1.8 1 0 0 1 1 1 1 P21-Rho-binding domain Pkinase_fungal PF17667.1 ADV23175.1 - 9e-06 24.7 0.0 9e-06 24.7 0.0 1.7 3 0 0 3 3 3 1 Fungal protein kinase Kinase-like PF14531.6 ADV23175.1 - 0.00017 21.0 0.0 0.00029 20.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 ADV23175.1 - 0.0005 19.5 0.0 0.0017 17.7 0.0 1.7 1 1 1 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ADV23175.1 - 0.0051 16.8 0.1 0.25 11.3 0.2 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ADV23175.1 - 0.1 11.5 0.1 0.2 10.5 0.1 1.4 1 1 0 1 1 1 0 Haspin like kinase domain Peptidase_S28 PF05577.12 ADV23177.1 - 3.2e-47 161.3 0.0 1.9e-46 158.8 0.0 2.1 1 1 0 1 1 1 1 Serine carboxypeptidase S28 Lactamase_B_2 PF12706.7 ADV23178.1 - 6.3e-14 52.0 0.0 3.1e-12 46.4 0.0 2.7 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_4 PF13691.6 ADV23178.1 - 9.7e-12 44.4 0.0 2.7e-11 43.0 0.0 1.8 1 0 0 1 1 1 1 tRNase Z endonuclease PRIMA1 PF16101.5 ADV23178.1 - 0.24 11.5 1.9 0.63 10.1 1.9 1.7 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 BLM10_mid PF16507.5 ADV23179.1 - 6.5e-155 516.7 0.0 9.7e-155 516.2 0.0 1.3 1 0 0 1 1 1 1 Proteasome-substrate-size regulator, mid region DUF3437 PF11919.8 ADV23179.1 - 5.3e-23 80.7 0.0 1.7e-20 72.7 0.0 3.6 3 0 0 3 3 3 1 Domain of unknown function (DUF3437) HEAT PF02985.22 ADV23179.1 - 0.00056 19.9 1.6 0.24 11.7 0.1 4.3 3 0 0 3 3 3 1 HEAT repeat HEAT_2 PF13646.6 ADV23179.1 - 0.0025 18.1 2.0 0.18 12.2 0.0 4.2 4 0 0 4 4 4 1 HEAT repeats Vac14_Fab1_bd PF12755.7 ADV23179.1 - 0.0037 17.8 0.0 6.2 7.5 0.0 2.8 2 0 0 2 2 2 2 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 ADV23179.1 - 0.096 12.7 0.1 0.35 10.9 0.1 1.9 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 2-Hacid_dh_C PF02826.19 ADV23180.1 - 6.8e-49 165.6 0.0 9.9e-49 165.1 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 ADV23180.1 - 8.6e-21 74.0 0.0 1e-20 73.8 0.0 1.0 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_7 PF13241.6 ADV23180.1 - 0.0013 19.1 0.0 0.0027 18.1 0.0 1.6 1 1 0 1 1 1 1 Putative NAD(P)-binding NAD_binding_2 PF03446.15 ADV23180.1 - 0.0054 16.9 0.0 0.0081 16.3 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase XdhC_C PF13478.6 ADV23180.1 - 0.0064 17.0 0.0 0.01 16.3 0.0 1.3 1 0 0 1 1 1 1 XdhC Rossmann domain Shikimate_DH PF01488.20 ADV23180.1 - 0.01 15.9 0.0 0.019 15.1 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Pyr_redox PF00070.27 ADV23180.1 - 0.062 13.9 0.0 0.13 12.8 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Glyco_trans_4_4 PF13579.6 ADV23180.1 - 0.091 13.2 0.1 0.18 12.2 0.0 1.7 2 0 0 2 2 2 0 Glycosyl transferase 4-like domain Oxidored_nitro PF00148.19 ADV23180.1 - 0.092 11.5 0.0 0.12 11.1 0.0 1.2 1 0 0 1 1 1 0 Nitrogenase component 1 type Oxidoreductase Glyco_transf_4 PF13439.6 ADV23180.1 - 0.11 12.5 0.0 0.24 11.4 0.0 1.5 1 0 0 1 1 1 0 Glycosyltransferase Family 4 ThiF PF00899.21 ADV23180.1 - 0.12 11.7 0.2 0.29 10.4 0.2 1.6 1 0 0 1 1 1 0 ThiF family Glyco_transf_5 PF08323.11 ADV23180.1 - 0.13 11.9 0.0 0.2 11.3 0.0 1.2 1 0 0 1 1 1 0 Starch synthase catalytic domain Robl_LC7 PF03259.17 ADV23181.1 - 2.3e-10 40.1 0.1 2.9e-10 39.8 0.1 1.1 1 0 0 1 1 1 1 Roadblock/LC7 domain TPR_2 PF07719.17 ADV23182.1 - 4.9e-07 29.4 13.6 0.079 13.1 0.0 6.6 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_19 PF14559.6 ADV23182.1 - 5.7e-05 23.6 0.6 0.044 14.3 0.0 3.7 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 ADV23182.1 - 0.00069 20.2 6.9 4 8.2 0.0 5.0 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 ADV23182.1 - 0.0038 17.9 3.9 17 6.6 0.0 6.2 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_7 PF13176.6 ADV23182.1 - 0.0055 16.6 3.2 3.2 8.0 0.1 4.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 ADV23182.1 - 0.036 14.4 0.1 6.7 7.3 0.0 4.3 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.28 ADV23182.1 - 0.05 13.4 10.4 11 6.1 0.0 6.4 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_12 PF13424.6 ADV23182.1 - 0.33 11.3 13.3 0.91 9.9 2.5 4.8 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_4 PF07721.14 ADV23182.1 - 1.5 9.7 6.5 1.7 9.5 0.1 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 ADV23182.1 - 4.9 6.9 6.7 38 4.1 0.3 3.8 4 0 0 4 4 4 0 TPR repeat RVT_1 PF00078.27 ADV23184.1 - 2.3e-11 43.7 0.0 7.9e-11 41.9 0.0 1.9 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Glyco_hydro_88 PF07470.13 ADV23185.1 - 5.5e-11 42.1 1.0 1.3e-10 41.0 1.0 1.6 1 1 0 1 1 1 1 Glycosyl Hydrolase Family 88 MFS_1 PF07690.16 ADV23186.1 - 2.6e-34 118.7 24.9 4.9e-34 117.8 24.8 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily OATP PF03137.20 ADV23186.1 - 1.2e-05 23.8 5.2 1.9e-05 23.2 5.2 1.3 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_4 PF06779.14 ADV23186.1 - 3.1e-05 23.4 1.3 3.1e-05 23.4 1.3 2.2 1 1 1 2 2 2 1 Uncharacterised MFS-type transporter YbfB Ni_hydr_CYTB PF01292.20 ADV23186.1 - 0.31 10.6 9.1 0.16 11.6 2.6 2.4 1 1 1 2 2 2 0 Prokaryotic cytochrome b561 Ribosomal_L12_N PF16320.5 ADV23188.1 - 2.8e-13 49.3 3.1 2.8e-13 49.3 3.1 2.2 2 1 0 2 2 2 1 Ribosomal protein L7/L12 dimerisation domain Ribosomal_L12 PF00542.19 ADV23188.1 - 1.7e-05 25.1 0.3 0.00053 20.3 0.1 2.3 2 0 0 2 2 2 1 Ribosomal protein L7/L12 C-terminal domain Ribosomal_60s PF00428.19 ADV23188.1 - 0.029 15.0 7.5 0.029 15.0 7.5 1.5 1 1 0 1 1 1 0 60s Acidic ribosomal protein tRNA-synt_1c PF00749.21 ADV23189.1 - 8.4e-95 317.3 0.2 1.2e-94 316.8 0.2 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 ADV23189.1 - 2.5e-35 121.9 0.1 4.1e-35 121.2 0.1 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain GST_C PF00043.25 ADV23189.1 - 1.3e-07 31.7 0.0 4.5e-07 30.0 0.0 2.0 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 ADV23189.1 - 1.1e-05 25.3 0.0 2.8e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Nop PF01798.18 ADV23190.1 - 6.1e-85 284.3 0.3 6.1e-85 284.3 0.3 1.7 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 ADV23190.1 - 3.1e-17 62.7 0.2 1.2e-16 60.8 0.2 2.2 1 0 0 1 1 1 1 NOP5NT (NUC127) domain NPR3 PF03666.13 ADV23190.1 - 0.039 12.7 0.1 0.039 12.7 0.1 2.2 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 Peptidase_M22 PF00814.25 ADV23191.1 - 9.4e-37 127.2 0.0 2.2e-36 126.0 0.0 1.5 1 1 0 1 1 1 1 Glycoprotease family DUF1746 PF08508.10 ADV23192.1 - 5.5e-06 26.7 1.5 6.3e-06 26.5 0.6 1.6 2 0 0 2 2 2 1 Fungal domain of unknown function (DUF1746) Sporozoite_P67 PF05642.11 ADV23192.1 - 1.4 6.9 3.3 1.9 6.4 3.3 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen AXE1 PF05448.12 ADV23193.1 - 0.001 17.8 0.1 0.0058 15.4 0.1 1.9 1 1 0 1 1 1 1 Acetyl xylan esterase (AXE1) Peptidase_S9 PF00326.21 ADV23193.1 - 0.0021 17.6 0.1 0.0032 17.0 0.1 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Esterase_phd PF10503.9 ADV23193.1 - 0.023 14.2 0.0 0.031 13.7 0.0 1.2 1 0 0 1 1 1 0 Esterase PHB depolymerase Abhydrolase_3 PF07859.13 ADV23193.1 - 0.034 14.0 0.0 0.052 13.4 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold RVT_2 PF07727.14 ADV23195.1 - 9.4e-13 48.4 0.0 1.8e-12 47.4 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 ADV23195.1 - 6.4e-05 23.1 0.1 0.0013 18.9 0.1 2.3 1 1 0 1 1 1 1 Integrase core domain zf-CCHC PF00098.23 ADV23195.1 - 0.00037 20.4 2.5 0.00083 19.3 2.5 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.6 ADV23195.1 - 0.58 10.0 2.5 1.1 9.1 2.5 1.5 1 0 0 1 1 1 0 Zinc knuckle F-box PF00646.33 ADV23196.1 - 1.7e-05 24.5 0.1 0.00016 21.4 0.0 2.4 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 ADV23196.1 - 0.00021 21.1 0.2 0.00059 19.7 0.2 1.8 1 0 0 1 1 1 1 F-box-like PRANC PF09372.10 ADV23196.1 - 0.11 12.9 0.0 0.5 10.7 0.0 2.2 2 0 0 2 2 2 0 PRANC domain Ctr PF04145.15 ADV23197.1 - 2.9e-11 44.2 0.0 4.2e-11 43.7 0.0 1.3 1 0 0 1 1 1 1 Ctr copper transporter family AA_permease_2 PF13520.6 ADV23199.1 - 3.5e-39 134.8 39.0 4.3e-39 134.5 39.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 ADV23199.1 - 1.8e-18 66.4 34.6 2.2e-18 66.1 34.6 1.0 1 0 0 1 1 1 1 Amino acid permease CTP_transf_like PF01467.26 ADV23200.1 - 1.8e-27 96.3 0.0 2.6e-27 95.8 0.0 1.2 1 0 0 1 1 1 1 Cytidylyltransferase-like Pneumo_att_G PF05539.11 ADV23200.1 - 0.98 8.9 11.8 1.4 8.4 11.8 1.1 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G ATG22 PF11700.8 ADV23204.1 - 4.3e-130 434.5 8.3 5.1e-130 434.3 8.3 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like MFS_1 PF07690.16 ADV23204.1 - 0.00016 20.8 25.9 0.00016 20.8 25.9 2.7 2 1 1 3 3 3 2 Major Facilitator Superfamily MCM_bind PF09739.9 ADV23204.1 - 0.051 12.0 0.1 0.071 11.6 0.1 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor RNA_pol_Rpb1_5 PF04998.17 ADV23207.1 - 1.3e-82 277.2 0.0 2e-82 276.6 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_1 PF04997.12 ADV23207.1 - 2.7e-79 266.8 0.0 4.2e-79 266.1 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 PF00623.20 ADV23207.1 - 1.7e-70 236.5 0.1 3e-70 235.7 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 ADV23207.1 - 6.3e-38 130.2 0.0 2.4e-37 128.3 0.0 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 ADV23207.1 - 3.3e-30 104.2 0.0 1.3e-29 102.3 0.0 2.1 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 Pox_A9 PF04835.12 ADV23207.1 - 0.18 12.0 0.0 0.36 11.0 0.0 1.4 1 0 0 1 1 1 0 A9 protein conserved region Sec1 PF00995.23 ADV23208.1 - 2.7e-121 406.6 0.0 3.1e-121 406.4 0.0 1.0 1 0 0 1 1 1 1 Sec1 family PH_12 PF16457.5 ADV23209.1 - 1.6e-28 99.9 0.0 2.8e-28 99.1 0.0 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain ELMO_CED12 PF04727.13 ADV23209.1 - 2e-16 60.6 0.5 1.3e-15 57.9 0.5 2.1 1 1 0 1 1 1 1 ELMO/CED-12 family DUF3361 PF11841.8 ADV23209.1 - 6.4e-11 42.4 0.0 6e-09 36.0 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF3361) Septin PF00735.18 ADV23210.1 - 2.6e-119 397.7 0.3 2.6e-119 397.7 0.3 1.5 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 ADV23210.1 - 1.8e-08 34.4 2.0 2.4e-08 34.1 0.0 2.2 2 1 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ADV23210.1 - 7e-08 32.5 4.6 9.7e-07 28.8 0.0 2.8 3 0 0 3 3 3 1 RsgA GTPase Ras PF00071.22 ADV23210.1 - 4.2e-05 23.2 0.3 0.00021 20.9 0.0 2.3 3 0 0 3 3 3 1 Ras family Roc PF08477.13 ADV23210.1 - 8.4e-05 22.8 0.0 0.0003 21.0 0.0 1.9 2 0 0 2 2 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.6 ADV23210.1 - 0.0006 20.1 0.1 0.0039 17.5 0.0 2.4 2 1 0 2 2 2 1 AAA domain AIG1 PF04548.16 ADV23210.1 - 0.00091 18.6 0.0 0.00091 18.6 0.0 2.2 2 1 0 2 2 2 1 AIG1 family ABC_tran PF00005.27 ADV23210.1 - 0.0032 18.0 7.3 0.0055 17.2 0.4 2.6 2 1 0 2 2 2 1 ABC transporter AAA_16 PF13191.6 ADV23210.1 - 0.0047 17.3 0.1 0.017 15.5 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain GTP_EFTU PF00009.27 ADV23210.1 - 0.0098 15.4 0.0 0.0098 15.4 0.0 3.5 2 2 0 3 3 3 1 Elongation factor Tu GTP binding domain AAA_29 PF13555.6 ADV23210.1 - 0.011 15.5 0.0 0.02 14.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Dynamin_N PF00350.23 ADV23210.1 - 0.027 14.5 5.5 1 9.4 0.1 3.3 2 1 1 3 3 3 0 Dynamin family ATP_bind_1 PF03029.17 ADV23210.1 - 0.19 11.5 5.4 0.87 9.3 0.0 3.1 2 1 1 3 3 3 0 Conserved hypothetical ATP binding protein Exonuc_VII_L PF02601.15 ADV23210.1 - 0.95 9.0 7.7 1.6 8.3 7.7 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Strep_SA_rep PF06696.11 ADV23210.1 - 1.7 8.7 8.3 0.28 11.2 3.4 2.3 1 1 1 2 2 2 0 Streptococcal surface antigen repeat DUF87 PF01935.17 ADV23210.1 - 3.2 7.8 6.1 26 4.8 0.0 2.4 2 0 0 2 2 2 0 Helicase HerA, central domain Atg14 PF10186.9 ADV23210.1 - 3.6 6.6 10.6 5.5 6.0 10.6 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Thaumatin PF00314.17 ADV23211.1 - 1.3e-25 90.3 2.0 1.5e-25 90.1 2.0 1.0 1 0 0 1 1 1 1 Thaumatin family DAGAT PF03982.13 ADV23214.1 - 1.2e-103 346.1 0.0 1.5e-103 345.8 0.0 1.0 1 0 0 1 1 1 1 Diacylglycerol acyltransferase dCMP_cyt_deam_1 PF00383.23 ADV23215.1 - 1.3e-20 73.1 0.1 2e-20 72.6 0.1 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 ADV23215.1 - 4.4e-20 71.8 0.0 6.1e-20 71.4 0.0 1.2 1 0 0 1 1 1 1 MafB19-like deaminase SNAD4 PF18750.1 ADV23215.1 - 0.00053 20.1 0.0 0.00087 19.4 0.0 1.2 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 4 APOBEC3 PF18771.1 ADV23215.1 - 0.0014 18.7 0.0 0.0021 18.2 0.0 1.2 1 0 0 1 1 1 1 APOBEC3 APOBEC4_like PF18774.1 ADV23215.1 - 0.0028 17.6 0.0 0.0044 17.0 0.0 1.2 1 0 0 1 1 1 1 APOBEC4-like -AID/APOBEC-deaminase Bd3614-deam PF14439.6 ADV23215.1 - 0.003 17.6 2.7 0.33 11.0 0.4 2.3 1 1 1 2 2 2 2 Bd3614-like deaminase NAD1 PF18778.1 ADV23215.1 - 0.0033 17.5 0.0 0.0049 17.0 0.0 1.2 1 0 0 1 1 1 1 Novel AID APOBEC clade 1 APOBEC_N PF08210.11 ADV23215.1 - 0.0042 17.0 0.0 0.0063 16.4 0.0 1.2 1 0 0 1 1 1 1 APOBEC-like N-terminal domain APOBEC2 PF18772.1 ADV23215.1 - 0.0082 16.2 0.0 0.012 15.7 0.0 1.1 1 0 0 1 1 1 1 APOBEC2 NAD2 PF18782.1 ADV23215.1 - 0.054 13.6 0.0 0.077 13.1 0.0 1.1 1 0 0 1 1 1 0 Novel AID APOBEC clade 2 XOO_2897-deam PF14440.6 ADV23215.1 - 0.13 12.4 0.0 0.21 11.7 0.0 1.3 1 0 0 1 1 1 0 Xanthomonas XOO_2897-like deaminase DUF908 PF06012.12 ADV23215.1 - 0.56 9.6 2.0 0.77 9.1 2.0 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Oxysterol_BP PF01237.18 ADV23216.1 - 8.8e-69 232.1 4.6 1.2e-61 208.7 0.1 2.0 1 1 1 2 2 2 2 Oxysterol-binding protein F-box-like_2 PF13013.6 ADV23217.1 - 0.047 13.7 0.1 0.083 12.9 0.1 1.4 1 0 0 1 1 1 0 F-box-like domain WD40 PF00400.32 ADV23218.1 - 4.9e-18 65.2 7.4 2.6e-05 24.9 0.2 7.1 8 0 0 8 8 8 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV23218.1 - 0.0005 20.3 0.1 0.48 10.8 0.0 3.3 3 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 ADV23218.1 - 0.062 13.8 0.1 13 6.4 0.0 3.7 4 0 0 4 4 4 0 PQQ-like domain HIG_1_N PF04588.13 ADV23219.1 - 5e-05 23.4 0.7 5e-05 23.4 0.7 1.9 2 0 0 2 2 2 1 Hypoxia induced protein conserved region MnhB PF04039.13 ADV23219.1 - 0.13 12.6 3.7 2.5 8.4 0.4 2.2 1 1 0 2 2 2 0 Domain related to MnhB subunit of Na+/H+ antiporter Thiamine_BP PF01910.17 ADV23220.1 - 2.6e-28 97.8 0.0 3.2e-28 97.5 0.0 1.1 1 0 0 1 1 1 1 Thiamine-binding protein Ykof PF07615.11 ADV23220.1 - 0.027 14.9 0.0 0.039 14.4 0.0 1.3 1 0 0 1 1 1 0 YKOF-related Family RRM_1 PF00076.22 ADV23221.1 - 6.6e-14 51.5 0.0 1.7e-05 24.5 0.0 3.0 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ADV23221.1 - 0.081 13.1 0.0 0.16 12.1 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif Pkinase PF00069.25 ADV23222.1 - 2e-42 145.4 0.0 3e-42 144.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV23222.1 - 4.5e-41 140.8 0.0 6.7e-40 137.0 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase SAP PF02037.27 ADV23222.1 - 0.00098 18.8 0.0 0.0034 17.1 0.0 2.0 1 0 0 1 1 1 1 SAP domain Pkinase_fungal PF17667.1 ADV23222.1 - 0.035 12.9 0.0 0.13 11.0 0.0 2.0 2 0 0 2 2 2 0 Fungal protein kinase APH PF01636.23 ADV23222.1 - 0.058 13.3 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family RhoGAP PF00620.27 ADV23223.1 - 1.6e-39 135.2 0.1 4.3e-39 133.8 0.1 1.8 1 0 0 1 1 1 1 RhoGAP domain FCH PF00611.23 ADV23223.1 - 8.9e-05 22.7 0.0 0.00035 20.8 0.0 2.1 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain UQ_con PF00179.26 ADV23224.1 - 1.3e-53 180.4 0.0 1.4e-53 180.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 ADV23224.1 - 0.0029 17.3 0.0 0.0034 17.1 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 ADV23224.1 - 0.033 14.5 0.0 0.038 14.3 0.0 1.2 1 0 0 1 1 1 0 RWD domain UEV PF05743.13 ADV23224.1 - 0.068 13.0 0.0 0.097 12.5 0.0 1.3 1 0 0 1 1 1 0 UEV domain PI3_PI4_kinase PF00454.27 ADV23225.1 - 1.6e-47 162.4 0.0 3e-47 161.6 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase TAN PF11640.8 ADV23225.1 - 4.3e-30 104.8 0.2 3.1e-28 98.8 0.2 3.2 2 0 0 2 2 2 1 Telomere-length maintenance and DNA damage repair FAT PF02259.23 ADV23225.1 - 9.8e-13 48.0 11.0 2e-12 47.0 11.0 1.5 1 0 0 1 1 1 1 FAT domain FATC PF02260.20 ADV23225.1 - 3.4e-09 36.4 0.1 7.8e-09 35.2 0.1 1.7 1 0 0 1 1 1 1 FATC domain HEAT PF02985.22 ADV23225.1 - 0.0061 16.7 0.1 6.1 7.4 0.0 4.2 3 0 0 3 3 3 1 HEAT repeat IBN_N PF03810.19 ADV23225.1 - 0.048 13.6 1.2 0.24 11.3 0.0 2.9 2 0 0 2 2 2 0 Importin-beta N-terminal domain PqqD PF05402.12 ADV23225.1 - 0.13 12.5 0.1 0.54 10.6 0.1 2.0 1 0 0 1 1 1 0 Coenzyme PQQ synthesis protein D (PqqD) PcfJ PF14284.6 ADV23225.1 - 0.68 9.8 2.9 0.36 10.7 0.2 1.8 2 0 0 2 2 2 0 PcfJ-like protein NAD_binding_2 PF03446.15 ADV23226.1 - 2.8e-24 86.1 0.0 4e-24 85.6 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 ADV23226.1 - 9.7e-06 25.8 0.0 4.6e-05 23.6 0.0 2.0 1 1 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase RhoGAP PF00620.27 ADV23227.1 - 4.6e-45 153.1 0.0 8.4e-45 152.3 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain FCH PF00611.23 ADV23227.1 - 7.8e-13 48.5 0.4 2.9e-12 46.7 0.1 2.1 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain DUF4942 PF13708.6 ADV23227.1 - 0.064 13.2 0.1 0.15 12.0 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4942) TBCA PF02970.16 ADV23227.1 - 0.77 10.1 6.5 0.14 12.5 1.4 2.4 2 0 0 2 2 2 0 Tubulin binding cofactor A COX6B PF02297.17 ADV23228.1 - 4.8e-20 71.6 5.3 5.4e-20 71.4 5.3 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb CX9C PF16860.5 ADV23228.1 - 0.00026 21.0 4.4 0.00036 20.5 4.4 1.2 1 0 0 1 1 1 1 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, APOBEC_C PF05240.14 ADV23228.1 - 0.00043 20.2 0.7 0.00057 19.8 0.7 1.3 1 0 0 1 1 1 1 APOBEC-like C-terminal domain ketoacyl-synt PF00109.26 ADV23228.1 - 0.019 14.6 0.0 0.019 14.6 0.0 1.0 1 0 0 1 1 1 0 Beta-ketoacyl synthase, N-terminal domain APOBEC_N PF08210.11 ADV23228.1 - 0.02 14.8 0.1 0.023 14.6 0.1 1.1 1 0 0 1 1 1 0 APOBEC-like N-terminal domain NAD2 PF18782.1 ADV23228.1 - 0.029 14.5 0.9 0.039 14.1 0.9 1.2 1 0 0 1 1 1 0 Novel AID APOBEC clade 2 CHCH PF06747.13 ADV23228.1 - 0.12 12.6 2.2 0.23 11.6 2.2 1.5 1 1 0 1 1 1 0 CHCH domain UPF0203 PF05254.12 ADV23228.1 - 0.4 11.0 7.5 0.44 10.8 1.2 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0203) Mitoc_mL59 PF18126.1 ADV23230.1 - 8.4e-19 68.1 6.0 1.6e-18 67.3 6.0 1.4 1 1 0 1 1 1 1 Mitochondrial ribosomal protein mL59 Cofac_haem_bdg PF04187.13 ADV23230.1 - 0.051 13.6 0.3 2.2 8.2 0.1 2.1 1 1 1 2 2 2 0 Haem-binding uptake, Tiki superfamily, ChaN ATP-synt_ab PF00006.25 ADV23231.1 - 1.5e-63 214.3 0.0 2.6e-63 213.5 0.0 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 ADV23231.1 - 4.6e-23 81.5 2.6 4.9e-23 81.4 0.8 2.1 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain RsgA_GTPase PF03193.16 ADV23231.1 - 0.0072 16.2 0.1 0.015 15.2 0.1 1.4 1 0 0 1 1 1 1 RsgA GTPase NB-ARC PF00931.22 ADV23231.1 - 0.0082 15.4 0.5 0.019 14.2 0.1 1.7 2 0 0 2 2 2 1 NB-ARC domain ATPase PF06745.13 ADV23231.1 - 0.012 15.0 0.2 0.022 14.1 0.2 1.4 1 0 0 1 1 1 0 KaiC ATPase_2 PF01637.18 ADV23231.1 - 0.02 14.8 0.0 0.04 13.8 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea RnfC_N PF13375.6 ADV23231.1 - 0.021 14.8 0.1 0.062 13.3 0.1 1.8 1 0 0 1 1 1 0 RnfC Barrel sandwich hybrid domain AAA_16 PF13191.6 ADV23231.1 - 0.026 14.9 0.2 0.092 13.1 0.2 2.0 1 1 0 1 1 1 0 AAA ATPase domain AAA PF00004.29 ADV23231.1 - 0.032 14.6 0.0 0.37 11.2 0.0 2.6 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 ADV23231.1 - 0.043 13.7 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 NACHT domain RNA_helicase PF00910.22 ADV23231.1 - 0.083 13.3 0.1 0.28 11.6 0.0 1.9 2 0 0 2 2 2 0 RNA helicase AAA_19 PF13245.6 ADV23231.1 - 0.13 12.6 0.9 0.38 11.1 0.2 2.0 2 0 0 2 2 2 0 AAA domain Med2 PF11214.8 ADV23231.1 - 0.13 12.4 0.2 0.83 9.8 0.0 2.4 3 0 0 3 3 3 0 Mediator complex subunit 2 Avl9 PF09794.9 ADV23234.1 - 2.5e-137 457.6 0.0 3.3e-137 457.2 0.0 1.1 1 0 0 1 1 1 1 Transport protein Avl9 SPA PF08616.10 ADV23234.1 - 3.5e-11 43.1 0.1 6.3e-06 26.1 0.0 2.4 2 0 0 2 2 2 2 Stabilization of polarity axis DUF2347 PF09804.9 ADV23234.1 - 2.4e-08 33.9 1.4 2e-06 27.6 0.1 2.9 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2347) Afi1 PF07792.12 ADV23234.1 - 0.001 19.6 1.0 0.0018 18.8 0.1 1.9 2 0 0 2 2 2 1 Docking domain of Afi1 for Arf3 in vesicle trafficking Cullin PF00888.22 ADV23235.1 - 5.7e-173 576.9 0.0 9.1e-173 576.2 0.0 1.3 2 0 0 2 2 2 1 Cullin family Cullin_Nedd8 PF10557.9 ADV23235.1 - 7e-30 102.9 4.5 7.8e-28 96.3 2.8 2.4 2 0 0 2 2 2 2 Cullin protein neddylation domain SR-25 PF10500.9 ADV23235.1 - 0.028 14.0 1.7 0.05 13.2 1.7 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein UCH PF00443.29 ADV23236.1 - 9.8e-45 153.0 0.0 1.3e-44 152.7 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ADV23236.1 - 3.8e-14 53.0 0.3 5e-12 46.0 0.3 2.1 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 ADV23236.1 - 2.2e-05 24.1 0.9 7.9e-05 22.3 0.2 2.3 2 0 0 2 2 2 1 Ubiquitin family Peptidase_M75 PF09375.10 ADV23236.1 - 0.039 13.4 0.2 0.084 12.3 0.2 1.5 1 0 0 1 1 1 0 Imelysin MFS_1 PF07690.16 ADV23237.1 - 8.5e-25 87.4 7.7 1.4e-17 63.7 0.6 2.4 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 ADV23237.1 - 8.6e-05 21.6 0.0 0.00077 18.4 0.0 2.3 1 1 0 1 1 1 1 MFS_1 like family ATG22 PF11700.8 ADV23237.1 - 4.5 5.8 15.1 0.071 11.7 5.2 2.3 2 1 0 2 2 2 0 Vacuole effluxer Atg22 like zf-MYND PF01753.18 ADV23238.1 - 0.082 13.0 6.1 0.35 11.0 6.4 1.8 1 1 1 2 2 2 0 MYND finger TraT PF05818.12 ADV23239.1 - 0.0011 18.7 0.0 0.0013 18.5 0.0 1.1 1 0 0 1 1 1 1 Enterobacterial TraT complement resistance protein Tim29 PF10171.9 ADV23239.1 - 0.043 13.3 0.0 0.046 13.2 0.0 1.1 1 0 0 1 1 1 0 Translocase of the Inner Mitochondrial membrane 29 DUF4838 PF16126.5 ADV23239.1 - 0.068 12.5 0.0 0.086 12.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4838) Fungal_trans_2 PF11951.8 ADV23240.1 - 1.9e-21 76.4 0.0 6.4e-21 74.6 0.0 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ADV23240.1 - 0.0069 16.5 5.0 0.0069 16.5 5.0 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PBP_GOBP PF01395.22 ADV23240.1 - 0.11 12.7 2.9 0.26 11.4 0.0 2.5 3 0 0 3 3 3 0 PBP/GOBP family Forkhead PF00250.18 ADV23242.1 - 3.9e-28 97.5 0.0 1.5e-27 95.7 0.0 1.9 2 0 0 2 2 2 1 Forkhead domain DUF4187 PF13821.6 ADV23243.1 - 4.8e-16 58.3 0.7 1.3e-15 56.8 0.7 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4187) G-patch PF01585.23 ADV23243.1 - 4e-06 26.6 8.0 4.6e-05 23.2 7.8 2.7 2 0 0 2 2 2 1 G-patch domain G-patch_2 PF12656.7 ADV23243.1 - 0.031 14.4 1.5 0.031 14.4 1.5 3.2 4 0 0 4 4 4 0 G-patch domain Med13_C PF06333.12 ADV23244.1 - 7e-07 28.8 0.7 7e-07 28.8 0.7 4.2 3 2 1 5 5 5 1 Mediator complex subunit 13 C-terminal domain CHAP PF05257.16 ADV23244.1 - 0.0092 16.5 1.5 0.023 15.3 1.5 1.6 1 0 0 1 1 1 1 CHAP domain HMMR_C PF15908.5 ADV23246.1 - 1.6e-05 25.2 7.6 1.6e-05 25.2 7.6 4.6 4 2 0 4 4 4 1 Hyaluronan mediated motility receptor C-terminal SOGA PF11365.8 ADV23246.1 - 0.00072 20.6 0.2 0.00072 20.6 0.2 7.3 2 2 6 9 9 9 1 Protein SOGA DUF4201 PF13870.6 ADV23246.1 - 0.013 15.2 1.5 0.013 15.2 1.5 6.6 2 2 3 6 6 6 0 Domain of unknown function (DUF4201) RNase_HII PF01351.18 ADV23246.1 - 8.4 6.2 11.5 0.54 10.1 3.9 2.5 2 1 0 2 2 2 0 Ribonuclease HII Ribosom_S12_S23 PF00164.25 ADV23247.1 - 7.5e-47 157.7 0.6 9.6e-47 157.3 0.6 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 G_glu_transpept PF01019.21 ADV23248.1 - 1.5e-130 436.4 0.0 1.7e-130 436.2 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase Ras PF00071.22 ADV23249.1 - 3.1e-48 163.4 0.0 4.2e-48 163.0 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ADV23249.1 - 2.3e-23 82.7 0.0 3.5e-23 82.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ADV23249.1 - 2.6e-08 33.5 0.0 3.6e-08 33.1 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ADV23249.1 - 2.7e-05 23.8 0.1 5.4e-05 22.8 0.0 1.5 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain PduV-EutP PF10662.9 ADV23249.1 - 0.00092 19.0 0.0 1.3 8.7 0.0 2.8 2 1 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation RsgA_GTPase PF03193.16 ADV23249.1 - 0.0028 17.6 0.0 0.64 9.9 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 ADV23249.1 - 0.02 14.3 0.0 0.024 14.0 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region AAA_7 PF12775.7 ADV23249.1 - 0.065 12.7 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_22 PF13401.6 ADV23249.1 - 0.08 13.2 0.0 0.17 12.2 0.0 1.6 2 0 0 2 2 2 0 AAA domain Mg_trans_NIPA PF05653.14 ADV23250.1 - 4.9e-94 314.7 27.2 6.5e-94 314.4 27.2 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 ADV23250.1 - 4.6e-07 30.1 12.2 4.6e-07 30.1 12.2 3.2 2 1 0 2 2 2 1 EamA-like transporter family SLATT_1 PF18181.1 ADV23250.1 - 0.26 11.2 1.1 1 9.3 0.5 2.3 1 1 1 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 1 PEMT PF04191.13 ADV23251.1 - 1.6e-53 179.6 10.8 2.8e-33 114.5 1.0 2.6 2 0 0 2 2 2 2 Phospholipid methyltransferase SKICH PF17751.1 ADV23251.1 - 0.02 15.4 0.0 0.071 13.7 0.0 1.9 1 1 0 1 1 1 0 SKICH domain HECW_N PF16562.5 ADV23251.1 - 0.1 12.4 0.0 0.22 11.3 0.0 1.5 1 0 0 1 1 1 0 N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2 ICMT PF04140.14 ADV23251.1 - 0.65 10.5 3.2 0.74 10.3 1.2 2.2 2 0 0 2 2 2 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family HSP9_HSP12 PF04119.12 ADV23253.1 - 3.8e-25 88.0 7.1 8.3e-25 87.0 4.5 1.9 2 0 0 2 2 2 1 Heat shock protein 9/12 DUF3484 PF11983.8 ADV23253.1 - 0.0042 18.2 0.3 0.0059 17.7 0.3 1.4 1 0 0 1 1 1 1 Membrane-attachment and polymerisation-promoting switch Alpha-amylase PF00128.24 ADV23254.1 - 1.8e-26 93.5 0.4 7.4e-26 91.5 0.4 1.8 1 1 0 1 1 1 1 Alpha amylase, catalytic domain Alpha-amylase_C PF02806.18 ADV23254.1 - 8.9e-12 45.3 0.1 2.4e-11 43.9 0.1 1.8 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain Glyco_hydro_70 PF02324.16 ADV23254.1 - 1.7e-06 26.6 0.0 0.0075 14.5 0.0 3.0 3 0 0 3 3 3 2 Glycosyl hydrolase family 70 DUF1939 PF09154.10 ADV23254.1 - 0.014 15.6 3.6 0.016 15.3 1.1 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF1939) Malt_amylase_C PF16657.5 ADV23254.1 - 0.074 13.2 0.0 0.52 10.5 0.0 2.1 2 0 0 2 2 2 0 Maltogenic Amylase, C-terminal domain SMC_N PF02463.19 ADV23255.1 - 6.7e-63 212.1 12.1 3.7e-62 209.7 12.1 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 ADV23255.1 - 1.8e-18 67.0 1.1 2.8e-17 63.1 0.4 3.0 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 ADV23255.1 - 3.8e-12 46.6 5.2 5.3e-05 23.2 0.2 3.8 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 ADV23255.1 - 4.2e-05 24.1 41.5 4.2e-05 24.1 41.5 6.0 2 2 0 2 2 2 1 AAA domain AAA_29 PF13555.6 ADV23255.1 - 4.6e-05 23.1 0.1 0.00011 21.8 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 ADV23255.1 - 0.00023 21.0 17.8 0.00023 21.0 17.8 4.5 2 2 1 3 3 3 1 AAA ATPase domain ABC_tran PF00005.27 ADV23255.1 - 0.17 12.4 27.5 0.55 10.7 0.0 6.3 3 2 0 3 3 3 0 ABC transporter Chrome_Resist PF09828.9 ADV23255.1 - 1.6 9.2 7.1 22 5.5 0.0 4.2 4 0 0 4 4 4 0 Chromate resistance exported protein PCI PF01399.27 ADV23256.1 - 4.4e-12 46.4 0.0 1.3e-11 45.0 0.0 1.7 2 0 0 2 2 2 1 PCI domain RPN7 PF10602.9 ADV23256.1 - 0.00099 18.8 0.0 0.0017 18.1 0.0 1.2 1 0 0 1 1 1 1 26S proteasome subunit RPN7 TPR_MalT PF17874.1 ADV23256.1 - 0.088 12.2 0.0 0.18 11.1 0.0 1.5 1 0 0 1 1 1 0 MalT-like TPR region CRAL_TRIO_N PF03765.15 ADV23257.1 - 9.6e-09 35.3 0.2 3.2e-08 33.6 0.1 2.0 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain CRAL_TRIO PF00650.20 ADV23257.1 - 1.7e-07 31.1 0.0 2.5e-07 30.6 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain ANTH PF07651.16 ADV23258.1 - 1.6e-49 168.4 0.0 2.2e-49 168.0 0.0 1.2 1 0 0 1 1 1 1 ANTH domain ENTH PF01417.20 ADV23258.1 - 0.00039 20.5 0.0 0.0008 19.5 0.0 1.5 1 0 0 1 1 1 1 ENTH domain DUF1720 PF08226.11 ADV23258.1 - 0.0072 16.7 8.1 0.0072 16.7 8.1 9.1 3 2 2 6 6 6 1 Domain of unknown function (DUF1720) CAP59_mtransfer PF11735.8 ADV23259.1 - 4.4e-52 177.2 0.0 5.5e-52 176.9 0.0 1.1 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 Ank_4 PF13637.6 ADV23260.1 - 1.3e-11 44.7 0.1 3.7e-05 24.2 0.1 2.7 3 1 0 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ADV23260.1 - 2.1e-11 44.2 0.0 6.1e-11 42.8 0.0 1.7 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ADV23260.1 - 9.9e-10 38.5 0.5 2.6e-07 30.8 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ADV23260.1 - 1e-08 34.7 0.1 0.0018 18.6 0.0 2.9 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 ADV23260.1 - 1.5e-06 28.3 0.1 0.0063 16.9 0.2 2.5 2 0 0 2 2 2 2 Ankyrin repeat F-box PF00646.33 ADV23261.1 - 2.4e-06 27.2 0.5 5.4e-06 26.2 0.5 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 ADV23261.1 - 8.4e-06 25.6 0.0 1.7e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 F-box-like F-box_4 PF15966.5 ADV23261.1 - 0.15 11.9 0.0 0.3 11.0 0.0 1.4 1 0 0 1 1 1 0 F-box Scs3p PF10261.9 ADV23262.1 - 5.2e-59 199.7 0.0 2.1e-57 194.5 0.0 2.1 1 1 0 1 1 1 1 Inositol phospholipid synthesis and fat-storage-inducing TM EF-hand_7 PF13499.6 ADV23264.1 - 1.1e-18 67.4 1.6 1.8e-10 41.1 0.9 2.7 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 ADV23264.1 - 3.3e-17 60.7 3.0 5.5e-05 22.4 0.1 4.3 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 ADV23264.1 - 5.3e-15 54.0 4.8 0.00038 20.2 0.1 4.0 4 0 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.6 ADV23264.1 - 3.6e-12 45.2 1.3 0.0037 16.7 0.1 3.5 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 ADV23264.1 - 1.2e-11 44.2 5.3 0.0015 18.4 0.6 4.3 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_9 PF14658.6 ADV23264.1 - 0.011 16.0 0.0 0.19 12.1 0.0 2.6 3 0 0 3 3 3 0 EF-hand domain SPARC_Ca_bdg PF10591.9 ADV23264.1 - 0.32 11.3 0.6 3 8.2 0.1 2.3 1 1 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Mito_carr PF00153.27 ADV23265.1 - 4.8e-59 196.3 0.5 3.6e-20 71.7 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein zf-UBP PF02148.19 ADV23266.1 - 2.2e-20 72.7 4.7 7.3e-20 71.1 3.3 2.4 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein BRAP2 PF07576.12 ADV23266.1 - 1.5e-18 66.9 0.0 2.9e-18 65.9 0.0 1.5 1 0 0 1 1 1 1 BRCA1-associated protein 2 zf-RING_2 PF13639.6 ADV23266.1 - 8.3e-08 32.5 7.7 8.3e-08 32.5 7.7 2.4 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 ADV23266.1 - 8.8e-06 25.5 6.7 8.8e-06 25.5 6.7 2.0 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ADV23266.1 - 7.2e-05 22.7 7.2 0.00022 21.2 7.2 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_11 PF17123.5 ADV23266.1 - 7.4e-05 22.4 1.5 0.00021 20.9 1.5 1.9 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_3 PF13920.6 ADV23266.1 - 0.00012 21.8 16.3 0.00051 19.9 5.3 2.4 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ADV23266.1 - 0.00014 21.7 5.0 0.00014 21.7 5.0 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ADV23266.1 - 0.0033 17.7 3.7 0.0033 17.7 3.7 2.2 2 0 0 2 2 1 1 RING-H2 zinc finger domain zf-RING_4 PF14570.6 ADV23266.1 - 0.044 13.6 5.5 0.093 12.5 5.5 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain HAUS6_N PF14661.6 ADV23266.1 - 1.1 8.8 6.2 2.6 7.5 6.2 1.7 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus Prok-RING_4 PF14447.6 ADV23266.1 - 1.1 9.2 21.3 0.5 10.3 9.7 3.4 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 Sugarporin_N PF11471.8 ADV23266.1 - 1.3 9.0 8.2 4.9 7.2 8.2 2.0 1 1 0 1 1 1 0 Maltoporin periplasmic N-terminal extension DUF4407 PF14362.6 ADV23266.1 - 1.3 8.3 4.7 2.2 7.5 4.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TMPIT PF07851.13 ADV23266.1 - 5.9 6.0 4.5 8.9 5.5 4.5 1.2 1 0 0 1 1 1 0 TMPIT-like protein XhlA PF10779.9 ADV23266.1 - 7 6.9 9.3 0.65 10.2 0.9 2.9 2 1 1 3 3 3 0 Haemolysin XhlA Phage_GP20 PF06810.11 ADV23266.1 - 7.1 6.4 10.5 18 5.1 10.4 1.6 1 1 0 1 1 1 0 Phage minor structural protein GP20 Rhomboid PF01694.22 ADV23267.1 - 8.4e-14 51.8 18.4 1.9e-13 50.6 15.8 2.4 2 1 0 2 2 2 1 Rhomboid family PMSR PF01625.21 ADV23269.1 - 3e-61 206.1 3.2 3.5e-61 205.8 3.2 1.0 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase Ndc1_Nup PF09531.10 ADV23270.1 - 5.3 5.6 4.9 5.9 5.5 4.9 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Sugar_tr PF00083.24 ADV23271.1 - 6.1e-62 210.0 23.5 7.4e-62 209.7 23.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ADV23271.1 - 4.5e-24 85.0 18.9 4.5e-24 85.0 18.9 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily Cullin PF00888.22 ADV23272.1 - 3.4e-120 402.5 1.5 5.1e-120 401.9 1.5 1.2 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 ADV23272.1 - 8.2e-22 77.0 0.5 2.3e-21 75.6 0.5 1.8 1 0 0 1 1 1 1 Cullin protein neddylation domain Sulfolobus_pRN PF05584.11 ADV23272.1 - 0.066 13.3 0.1 0.19 11.8 0.1 1.8 1 0 0 1 1 1 0 Sulfolobus plasmid regulatory protein RGS_DHEX PF18148.1 ADV23272.1 - 0.22 11.6 1.3 1.2 9.3 0.1 2.5 2 0 0 2 2 2 0 Regulator of G-protein signalling DHEX domain CDT1_C PF16679.5 ADV23272.1 - 9.5 6.7 8.3 24 5.4 1.9 2.8 2 0 0 2 2 2 0 DNA replication factor Cdt1 C-terminal domain Pkinase PF00069.25 ADV23273.1 - 1e-32 113.6 0.0 1e-26 93.9 0.0 3.0 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ADV23273.1 - 1.7e-09 37.4 0.0 7.4e-09 35.3 0.0 2.0 2 1 0 2 2 2 1 Protein tyrosine kinase Seadorna_VP7 PF07387.11 ADV23273.1 - 0.0016 17.5 0.0 0.0024 17.0 0.0 1.1 1 0 0 1 1 1 1 Seadornavirus VP7 APH PF01636.23 ADV23273.1 - 0.12 12.2 0.1 1.3 8.9 0.0 2.2 2 0 0 2 2 2 0 Phosphotransferase enzyme family PTPRCAP PF15713.5 ADV23274.1 - 0.15 12.3 3.4 0.36 11.1 3.4 1.5 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated TFIIF_alpha PF05793.12 ADV23274.1 - 4.4 5.8 6.5 0.2 10.2 1.1 1.5 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) 3HCDH_N PF02737.18 ADV23275.1 - 1.1e-43 149.2 0.0 2.2e-43 148.2 0.0 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 ADV23275.1 - 1.9e-34 118.1 0.0 5.1e-34 116.8 0.0 1.8 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain ATG_C PF09333.11 ADV23276.1 - 0.002 18.5 0.0 0.013 15.8 0.0 2.3 3 0 0 3 3 3 1 Autophagy-related protein C terminal domain VPS13_C PF16909.5 ADV23276.1 - 0.015 15.1 0.1 0.028 14.2 0.1 1.4 1 0 0 1 1 1 0 Vacuolar-sorting-associated 13 protein C-terminal Attacin_C PF03769.15 ADV23276.1 - 0.23 11.7 0.0 0.56 10.5 0.0 1.5 1 0 0 1 1 1 0 Attacin, C-terminal region SIR2 PF02146.17 ADV23277.1 - 2e-53 180.9 0.0 2.9e-53 180.4 0.0 1.3 1 0 0 1 1 1 1 Sir2 family zf-C2H2 PF00096.26 ADV23278.1 - 1.7e-24 84.8 65.1 0.00053 20.3 1.8 10.2 10 0 0 10 10 10 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ADV23278.1 - 3e-19 68.0 64.3 0.0036 18.0 1.3 10.5 10 0 0 10 10 10 7 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ADV23278.1 - 6e-08 32.8 65.6 0.0034 17.8 0.7 11.7 12 0 0 12 12 12 4 Zinc-finger double domain zf-C2H2_8 PF15909.5 ADV23278.1 - 6.1e-08 32.9 25.9 0.0017 18.6 4.3 5.8 3 1 3 6 6 6 4 C2H2-type zinc ribbon zf-C2H2_jaz PF12171.8 ADV23278.1 - 0.00038 20.7 27.3 0.08 13.3 0.4 7.5 9 0 0 9 9 8 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 ADV23278.1 - 0.0058 17.0 0.8 0.13 12.7 0.2 6.2 7 0 0 7 7 6 2 Zinc-finger of C2H2 type Actin_micro PF17003.5 ADV23278.1 - 0.029 13.6 4.6 0.12 11.5 2.4 2.8 2 1 0 2 2 2 0 Putative actin-like family DUF4716 PF15837.5 ADV23278.1 - 0.038 14.0 0.4 4.6 7.4 0.0 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4716) zf-C2H2_11 PF16622.5 ADV23278.1 - 0.059 13.2 4.1 9.1 6.1 0.1 4.4 4 0 0 4 4 4 0 zinc-finger C2H2-type CHORD PF04968.12 ADV23278.1 - 0.069 13.9 28.2 6.8 7.5 0.4 5.9 5 0 0 5 5 5 0 CHORD zf-C2H2_6 PF13912.6 ADV23278.1 - 0.12 12.4 29.5 0.81 9.8 0.2 7.0 7 0 0 7 7 7 0 C2H2-type zinc finger zf_ZIC PF18366.1 ADV23278.1 - 0.59 10.3 15.2 1.7 8.8 0.1 5.4 6 0 0 6 6 6 0 Zic proteins zinc finger domain zf-C2H2_aberr PF17017.5 ADV23278.1 - 3.3 7.8 30.0 4.9 7.3 0.4 6.3 4 3 2 7 7 7 0 Aberrant zinc-finger YdjO PF14169.6 ADV23278.1 - 8.1 6.3 11.4 13 5.6 0.3 5.0 5 1 0 5 5 5 0 Cold-inducible protein YdjO PIG-X PF08320.12 ADV23280.1 - 2.3e-20 73.4 0.8 1.1e-12 48.3 0.0 2.2 2 0 0 2 2 2 2 PIG-X / PBN1 WD40 PF00400.32 ADV23281.1 - 1.3e-40 136.6 14.3 1.5e-08 35.1 0.1 11.6 12 0 0 12 12 12 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV23281.1 - 1.4e-23 83.0 0.0 0.00066 19.9 0.0 9.6 3 2 7 11 11 11 4 Anaphase-promoting complex subunit 4 WD40 domain Utp12 PF04003.12 ADV23281.1 - 2.9e-22 79.0 0.0 5.1e-22 78.2 0.0 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family Ge1_WD40 PF16529.5 ADV23281.1 - 6.5e-10 38.5 0.2 0.11 11.4 0.0 6.5 3 3 4 7 7 7 3 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ADV23281.1 - 1.7e-08 34.2 0.2 0.35 10.9 0.0 6.8 8 0 0 8 8 8 2 WD40-like Beta Propeller Repeat Gmad1 PF10647.9 ADV23281.1 - 2e-05 24.5 0.0 3.3 7.4 0.0 4.6 4 1 1 5 5 5 2 Lipoprotein LpqB beta-propeller domain Coatomer_WDAD PF04053.14 ADV23281.1 - 3.4e-05 23.1 0.0 0.0037 16.4 0.0 3.0 3 0 0 3 3 3 1 Coatomer WD associated region eIF2A PF08662.11 ADV23281.1 - 0.00019 21.4 2.0 0.92 9.4 0.0 4.7 3 2 1 4 4 4 2 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 ADV23281.1 - 0.0014 17.2 0.4 2 6.8 0.1 4.0 4 1 0 4 4 4 1 Cytochrome D1 heme domain WD40_like PF17005.5 ADV23281.1 - 0.0028 17.0 0.0 0.45 9.8 0.0 2.8 3 0 0 3 3 3 1 WD40-like domain ELYS-bb PF16687.5 ADV23281.1 - 0.012 14.3 0.0 0.032 12.8 0.0 1.7 2 0 0 2 2 2 0 beta-propeller of ELYS nucleoporin DUF1513 PF07433.11 ADV23281.1 - 0.018 14.2 0.3 9.2 5.2 0.0 4.2 4 1 0 4 4 4 0 Protein of unknown function (DUF1513) Proteasome_A_N PF10584.9 ADV23281.1 - 2 8.2 5.8 25 4.7 0.0 4.5 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature Alpha-amylase PF00128.24 ADV23282.1 - 4.9e-20 72.4 1.4 7.2e-19 68.5 0.9 2.8 2 1 0 2 2 2 1 Alpha amylase, catalytic domain Glyco_transf_5 PF08323.11 ADV23282.1 - 7.3e-17 61.9 0.1 1.3e-16 61.1 0.1 1.3 1 0 0 1 1 1 1 Starch synthase catalytic domain Glycos_transf_1 PF00534.20 ADV23282.1 - 8e-08 32.0 0.0 1.6e-07 31.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 RexB PF15968.5 ADV23282.1 - 0.21 12.0 7.1 6.1 7.3 1.7 2.5 2 0 0 2 2 2 0 Membrane-anchored ion channel, Abi component BNR PF02012.20 ADV23282.1 - 1.7 9.0 3.9 0.72 10.1 0.1 2.6 2 0 0 2 2 2 0 BNR/Asp-box repeat BRCT_2 PF16589.5 ADV23283.1 - 0.0026 18.1 0.1 0.0085 16.5 0.1 1.8 1 1 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT_2 PF16589.5 ADV23284.1 - 3.3e-10 40.2 0.0 6.9e-10 39.2 0.0 1.6 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain Glycos_transf_1 PF00534.20 ADV23288.1 - 6.4e-16 58.4 0.0 1.6e-15 57.1 0.0 1.6 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ADV23288.1 - 1.9e-11 44.5 0.0 6.2e-11 42.9 0.0 1.9 2 0 0 2 2 2 1 Glycosyl transferases group 1 Myc-LZ PF02344.15 ADV23289.1 - 0.049 13.7 4.2 0.15 12.2 4.2 1.8 1 0 0 1 1 1 0 Myc leucine zipper domain DUF1664 PF07889.12 ADV23289.1 - 0.11 12.6 1.5 5.3 7.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) THOC7 PF05615.13 ADV23289.1 - 0.15 12.3 5.4 0.27 11.5 2.2 2.3 2 0 0 2 2 2 0 Tho complex subunit 7 DUF5320 PF17253.2 ADV23289.1 - 0.16 13.0 4.0 0.4 11.8 1.6 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5320) PBP PF01161.20 ADV23290.1 - 2.6e-10 40.7 0.2 4.5e-10 40.0 0.2 1.3 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein Mog1 PF04603.12 ADV23291.1 - 3e-27 95.7 0.0 3.7e-27 95.4 0.0 1.1 1 0 0 1 1 1 1 Ran-interacting Mog1 protein PPR PF01535.20 ADV23292.1 - 0.087 13.1 0.0 1.7e+02 2.8 0.0 4.0 4 0 0 4 4 4 0 PPR repeat Formyl_trans_N PF00551.19 ADV23292.1 - 0.17 11.6 0.1 3.4 7.4 0.0 2.3 1 1 1 2 2 2 0 Formyl transferase MFS_1 PF07690.16 ADV23293.1 - 1.2e-27 96.8 61.9 7.2e-27 94.2 56.8 2.8 2 1 0 2 2 2 1 Major Facilitator Superfamily FAD_binding_8 PF08022.12 ADV23295.1 - 3.8e-14 52.7 0.0 8.9e-14 51.5 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 ADV23295.1 - 1.7e-07 31.5 0.0 1.7e-07 31.5 0.0 2.6 3 0 0 3 3 3 1 Ferric reductase NAD binding domain BatD PF13584.6 ADV23295.1 - 0.12 11.1 4.0 0.027 13.3 0.7 1.5 2 0 0 2 2 2 0 Oxygen tolerance NPR3 PF03666.13 ADV23295.1 - 0.24 10.1 9.4 1.7 7.3 0.1 2.1 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 Macoilin PF09726.9 ADV23295.1 - 2.2 6.7 16.9 3.1 6.2 16.9 1.2 1 0 0 1 1 1 0 Macoilin family DUF4614 PF15391.6 ADV23295.1 - 2.2 8.2 25.8 0.18 11.8 19.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4614) Apt1 PF10351.9 ADV23295.1 - 3.4 6.4 16.3 5.3 5.8 16.3 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain Presenilin PF01080.17 ADV23295.1 - 4.3 6.0 6.6 8.6 5.0 6.6 1.6 1 0 0 1 1 1 0 Presenilin Herpes_DNAp_acc PF04929.12 ADV23297.1 - 0.13 11.3 7.8 0.16 10.9 7.8 1.1 1 0 0 1 1 1 0 Herpes DNA replication accessory factor Chitin_synth_2 PF03142.15 ADV23300.1 - 9.9e-272 902.2 0.0 1.3e-271 901.8 0.0 1.1 1 0 0 1 1 1 1 Chitin synthase Glyco_tranf_2_3 PF13641.6 ADV23300.1 - 5.4e-15 55.9 0.0 1.2e-13 51.5 0.1 2.3 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 ADV23300.1 - 7.2e-13 48.9 5.3 7.2e-13 48.9 5.3 2.7 3 1 0 3 3 3 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 ADV23300.1 - 0.00013 21.8 0.0 0.011 15.5 0.0 2.5 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 ADV23300.1 - 0.0051 16.3 0.0 0.012 15.0 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 21 Cyt-b5 PF00173.28 ADV23300.1 - 0.16 12.1 0.0 1.8 8.8 0.0 2.6 2 1 0 2 2 2 0 Cytochrome b5-like Heme/Steroid binding domain DUF4111 PF13427.6 ADV23301.1 - 2.8e-08 33.9 0.0 6.3e-08 32.7 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4111) Polbeta PF18765.1 ADV23301.1 - 0.004 17.2 0.0 0.0075 16.3 0.0 1.4 1 0 0 1 1 1 1 Polymerase beta, Nucleotidyltransferase Adenyl_cycl_N PF12633.7 ADV23301.1 - 0.057 13.3 0.0 0.089 12.7 0.0 1.3 1 0 0 1 1 1 0 Adenylate cyclase NT domain Dynactin_p22 PF07426.11 ADV23302.1 - 2.6e-07 30.6 0.1 0.0013 18.6 0.1 2.6 2 1 0 2 2 2 2 Dynactin subunit p22 DUF3760 PF12586.8 ADV23303.1 - 6.3e-18 64.7 0.5 2e-17 63.1 0.5 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF3760) RIFIN PF02009.16 ADV23304.1 - 0.0016 18.5 0.7 0.0041 17.1 0.1 1.7 1 1 0 1 1 1 1 Rifin FeoB_associated PF12669.7 ADV23304.1 - 0.56 10.7 1.8 0.94 9.9 1.8 1.3 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein Stevor PF17410.2 ADV23304.1 - 1.1 8.8 2.3 1.1 8.7 0.6 1.8 1 1 0 1 1 1 0 Subtelomeric Variable Open Reading frame Pkinase PF00069.25 ADV23305.1 - 1.4e-57 195.1 0.0 1.8e-57 194.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV23305.1 - 5e-21 75.2 0.0 6.8e-21 74.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ADV23305.1 - 3.6e-05 23.2 0.0 6.4e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 ADV23305.1 - 0.0042 16.1 0.0 0.0073 15.3 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain SIR2 PF02146.17 ADV23306.1 - 2.2e-22 79.9 0.0 3.4e-22 79.2 0.0 1.3 1 1 0 1 1 1 1 Sir2 family CPSF_A PF03178.15 ADV23307.1 - 1.1e-60 205.7 0.0 2.2e-60 204.7 0.0 1.5 1 0 0 1 1 1 1 CPSF A subunit region MMS1_N PF10433.9 ADV23307.1 - 2.4e-42 145.2 0.0 4.7e-42 144.2 0.0 1.4 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term Wtap PF17098.5 ADV23308.1 - 0.0096 15.9 1.1 0.094 12.6 0.2 2.3 2 0 0 2 2 2 1 WTAP/Mum2p family SOGA PF11365.8 ADV23308.1 - 0.015 16.4 0.6 0.3 12.2 0.0 2.8 2 2 1 3 3 3 0 Protein SOGA GOLGA2L5 PF15070.6 ADV23308.1 - 0.16 10.6 1.3 6.2 5.4 0.1 2.1 2 0 0 2 2 2 0 Putative golgin subfamily A member 2-like protein 5 bZIP_1 PF00170.21 ADV23308.1 - 0.46 10.6 3.0 23 5.2 0.3 2.6 2 0 0 2 2 2 0 bZIP transcription factor Peroxin-13_N PF04088.13 ADV23309.1 - 0.037 14.3 0.0 0.054 13.8 0.0 1.2 1 0 0 1 1 1 0 Peroxin 13, N-terminal region TFIID_20kDa PF03847.13 ADV23310.1 - 4.5e-05 23.9 0.0 7.6e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A SNRNP27 PF08648.12 ADV23311.1 - 1.5e-26 92.2 0.9 3.2e-26 91.1 0.9 1.6 1 0 0 1 1 1 1 U4/U6.U5 small nuclear ribonucleoproteins Mad3_BUB1_I PF08311.12 ADV23312.1 - 2.4e-32 111.5 0.2 4.6e-32 110.6 0.2 1.4 1 0 0 1 1 1 1 Mad3/BUB1 homology region 1 Pkinase PF00069.25 ADV23312.1 - 4.7e-11 42.5 0.0 2.6e-10 40.1 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Mad3_BUB1_II PF08171.11 ADV23312.1 - 1.9e-09 37.6 0.0 4.2e-08 33.2 0.0 3.0 3 0 0 3 3 3 1 Mad3/BUB1 homology region 2 Pkinase_Tyr PF07714.17 ADV23312.1 - 1.3e-05 24.7 0.0 2.1e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Hemerythrin PF01814.23 ADV23312.1 - 0.018 15.7 1.3 0.15 12.7 1.4 2.3 2 0 0 2 2 2 0 Hemerythrin HHE cation binding domain Mad3_BUB1_I_2 PF17014.5 ADV23312.1 - 0.019 15.1 0.5 0.04 14.1 0.0 1.6 2 0 0 2 2 2 0 Putative Mad3/BUB1 like region 1 protein FMN_red PF03358.15 ADV23313.1 - 2.9e-24 85.6 0.0 4.9e-24 84.8 0.0 1.3 1 0 0 1 1 1 1 NADPH-dependent FMN reductase FoP_duplication PF13865.6 ADV23313.1 - 2.2e-07 31.3 3.0 8.1e-07 29.5 3.0 2.0 1 0 0 1 1 1 1 C-terminal duplication domain of Friend of PRMT1 Flavodoxin_2 PF02525.17 ADV23313.1 - 0.00013 21.8 0.0 0.00019 21.2 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin-like fold Amino_oxidase PF01593.24 ADV23314.1 - 1.6e-36 126.6 0.0 1.9e-36 126.4 0.0 1.0 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 ADV23314.1 - 3.8e-08 33.4 0.1 1.7e-07 31.3 0.2 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 ADV23314.1 - 1.1e-07 31.8 0.1 0.00034 20.3 0.1 2.4 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox PF00070.27 ADV23314.1 - 0.0016 19.0 0.2 1.7 9.2 0.0 2.8 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 ADV23314.1 - 0.017 15.1 0.0 0.034 14.1 0.0 1.5 1 0 0 1 1 1 0 FAD-NAD(P)-binding MCRA PF06100.11 ADV23314.1 - 0.043 12.6 0.0 0.063 12.1 0.0 1.2 1 0 0 1 1 1 0 MCRA family Thi4 PF01946.17 ADV23314.1 - 0.047 12.9 0.0 0.088 12.0 0.0 1.4 1 0 0 1 1 1 0 Thi4 family Trp_halogenase PF04820.14 ADV23314.1 - 0.061 12.2 0.1 0.088 11.6 0.1 1.2 1 0 0 1 1 1 0 Tryptophan halogenase Pyr_redox_2 PF07992.14 ADV23314.1 - 0.22 10.7 0.9 0.46 9.7 0.0 1.9 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Exo_endo_phos PF03372.23 ADV23315.1 - 9.2e-18 64.6 0.9 8.1e-17 61.5 0.0 2.5 2 1 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family LRR_8 PF13855.6 ADV23315.1 - 2.8e-08 33.4 6.3 1.1e-06 28.3 0.9 2.3 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 ADV23315.1 - 6.4e-07 29.6 4.5 0.00095 19.5 0.1 2.6 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) A_deamin PF02137.18 ADV23316.1 - 9.8e-49 166.6 0.0 6.8e-48 163.8 0.0 1.9 1 1 0 1 1 1 1 Adenosine-deaminase (editase) domain Sacchrp_dh_NADP PF03435.18 ADV23317.1 - 4.7e-13 49.5 0.0 8.2e-13 48.8 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Semialdhyde_dh PF01118.24 ADV23317.1 - 0.0074 16.7 0.0 0.022 15.2 0.0 1.9 2 1 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain NAD_binding_10 PF13460.6 ADV23317.1 - 0.032 14.1 0.0 0.06 13.2 0.0 1.4 1 0 0 1 1 1 0 NAD(P)H-binding Pribosyltran PF00156.27 ADV23318.1 - 2.6e-12 46.5 0.0 3.7e-12 46.0 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain PRTase_2 PF15609.6 ADV23318.1 - 0.00013 21.6 0.0 0.0002 20.9 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase Zeta_toxin PF06414.12 ADV23318.1 - 0.15 11.4 0.0 15 4.8 0.2 2.1 1 1 1 2 2 2 0 Zeta toxin Ribosomal_S8e PF01201.22 ADV23319.1 - 6.1e-53 178.7 0.6 7.2e-53 178.4 0.6 1.1 1 0 0 1 1 1 1 Ribosomal protein S8e ODC_AZ PF02100.17 ADV23320.1 - 8.3e-22 77.3 0.0 1.3e-21 76.7 0.0 1.2 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme CBFD_NFYB_HMF PF00808.23 ADV23321.1 - 9e-13 48.3 0.4 9e-13 48.3 0.4 1.9 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 ADV23321.1 - 7.6e-07 29.6 2.5 1.2e-06 29.0 0.1 2.2 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 HhH-GPD PF00730.25 ADV23323.1 - 7.3e-20 71.4 0.0 1.5e-19 70.4 0.0 1.6 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 ADV23323.1 - 9.6e-06 25.2 0.1 2.2e-05 24.1 0.1 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif SCA7 PF08313.12 ADV23324.1 - 7.8e-26 89.8 0.3 7.8e-26 89.8 0.3 2.0 2 0 0 2 2 2 1 SCA7, zinc-binding domain MAS20 PF02064.15 ADV23324.1 - 0.0009 19.3 0.4 0.0009 19.3 0.4 2.3 2 0 0 2 2 2 1 MAS20 protein import receptor SR-25 PF10500.9 ADV23324.1 - 0.48 10.0 18.0 0.23 11.0 8.3 2.3 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein zf-FPG_IleRS PF06827.14 ADV23324.1 - 4.8 7.1 5.9 23 5.0 0.0 3.3 3 0 0 3 3 3 0 Zinc finger found in FPG and IleRS MFS_1 PF07690.16 ADV23325.1 - 1.5e-50 172.1 17.4 3.8e-49 167.5 16.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ADV23325.1 - 2.6e-18 66.1 4.7 1.7e-13 50.3 0.4 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter TRI12 PF06609.13 ADV23325.1 - 6.9e-05 21.5 3.1 6.9e-05 21.5 3.1 1.9 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.20 ADV23325.1 - 0.001 17.5 8.8 0.0088 14.4 0.6 3.4 2 1 1 3 3 3 2 Organic Anion Transporter Polypeptide (OATP) family MFS_2 PF13347.6 ADV23325.1 - 0.0052 15.4 0.7 0.0052 15.4 0.7 2.9 3 0 0 3 3 3 1 MFS/sugar transport protein TMEM100 PF16311.5 ADV23325.1 - 0.46 10.1 2.3 14 5.3 0.2 2.6 2 0 0 2 2 2 0 Transmembrane protein 100 MFS_3 PF05977.13 ADV23325.1 - 0.62 8.4 6.6 0.042 12.2 1.6 1.4 2 0 0 2 2 2 0 Transmembrane secretion effector DUF4519 PF15012.6 ADV23325.1 - 10 6.4 9.6 28 5.0 9.6 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4519) AAA PF00004.29 ADV23326.1 - 4.7e-42 143.5 0.0 1.5e-41 141.9 0.0 1.9 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ADV23326.1 - 1.3e-07 31.3 0.3 2.8e-07 30.2 0.3 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 ADV23326.1 - 1.3e-05 25.2 0.0 8.7e-05 22.5 0.0 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ADV23326.1 - 4.8e-05 23.6 0.0 0.0054 17.0 0.0 2.5 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 ADV23326.1 - 0.00022 21.6 0.2 0.0034 17.8 0.1 2.5 2 1 1 3 3 3 1 AAA ATPase domain DUF815 PF05673.13 ADV23326.1 - 0.0003 20.0 0.0 0.00055 19.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_2 PF07724.14 ADV23326.1 - 0.00031 20.9 0.0 0.00091 19.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 ADV23326.1 - 0.004 16.9 0.0 0.0083 15.9 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_7 PF12775.7 ADV23326.1 - 0.0057 16.2 0.0 0.015 14.8 0.0 1.7 1 1 0 1 1 1 1 P-loop containing dynein motor region ATPase_2 PF01637.18 ADV23326.1 - 0.0096 15.9 0.6 2.7 7.8 0.0 2.9 2 1 1 3 3 3 1 ATPase domain predominantly from Archaea AAA_24 PF13479.6 ADV23326.1 - 0.012 15.4 0.1 0.17 11.6 0.0 2.7 4 0 0 4 4 4 0 AAA domain AAA_28 PF13521.6 ADV23326.1 - 0.014 15.6 0.0 0.029 14.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 ADV23326.1 - 0.027 14.9 0.0 0.068 13.6 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_33 PF13671.6 ADV23326.1 - 0.051 13.7 0.0 0.1 12.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain Sigma54_activ_2 PF14532.6 ADV23326.1 - 0.053 13.6 0.0 0.13 12.3 0.0 1.7 2 0 0 2 2 1 0 Sigma-54 interaction domain AAA_3 PF07726.11 ADV23326.1 - 0.056 13.3 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 ADV23326.1 - 0.056 12.8 0.0 0.13 11.6 0.0 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI TIP49 PF06068.13 ADV23326.1 - 0.057 12.6 0.1 0.13 11.4 0.0 1.5 2 0 0 2 2 2 0 TIP49 P-loop domain AAA_14 PF13173.6 ADV23326.1 - 0.066 13.2 0.1 0.21 11.6 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 ADV23326.1 - 0.067 13.7 0.0 0.12 12.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 ADV23326.1 - 0.09 12.5 0.0 0.25 11.0 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain IstB_IS21 PF01695.17 ADV23326.1 - 0.14 11.8 0.0 0.28 10.9 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein Pam17 PF08566.10 ADV23327.1 - 2.7e-58 196.5 0.0 3.3e-58 196.2 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial import protein Pam17 HTH_Tnp_Tc3_2 PF01498.18 ADV23327.1 - 0.022 15.0 0.0 0.039 14.2 0.0 1.3 1 0 0 1 1 1 0 Transposase HTH_48 PF17906.1 ADV23327.1 - 0.19 11.9 0.0 0.33 11.1 0.0 1.4 1 0 0 1 1 1 0 HTH domain in Mos1 transposase DBR1 PF05011.13 ADV23329.1 - 5e-36 124.2 0.0 1.2e-35 123.0 0.0 1.7 1 0 0 1 1 1 1 Lariat debranching enzyme, C-terminal domain Usp PF00582.26 ADV23330.1 - 8.2e-15 55.5 0.5 1.4e-14 54.8 0.5 1.4 1 0 0 1 1 1 1 Universal stress protein family baeRF_family2 PF18844.1 ADV23330.1 - 0.054 13.6 0.3 0.11 12.6 0.3 1.4 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 2 Peptidase_M43 PF05572.13 ADV23331.1 - 0.13 12.1 0.0 0.16 11.9 0.0 1.1 1 0 0 1 1 1 0 Pregnancy-associated plasma protein-A Yippee-Mis18 PF03226.14 ADV23332.1 - 4.2e-16 59.1 0.0 5.2e-16 58.8 0.0 1.1 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Zn_ribbon_SprT PF17283.2 ADV23332.1 - 0.0037 17.1 1.4 1.1 9.2 0.3 2.3 2 0 0 2 2 2 2 SprT-like zinc ribbon domain Jas PF16135.5 ADV23332.1 - 0.015 15.5 0.4 4 7.7 0.1 2.3 2 0 0 2 2 2 0 TPL-binding domain in jasmonate signalling RNA_POL_M_15KD PF02150.16 ADV23332.1 - 0.046 13.6 0.4 1.1 9.2 0.0 2.3 2 0 0 2 2 2 0 RNA polymerases M/15 Kd subunit HNH_5 PF14279.6 ADV23332.1 - 0.049 13.5 0.1 0.96 9.4 0.0 2.2 2 0 0 2 2 2 0 HNH endonuclease Arv1 PF04161.13 ADV23334.1 - 3.9e-22 79.4 0.0 5.4e-22 79.0 0.0 1.3 1 1 0 1 1 1 1 Arv1-like family ATPase_gene1 PF09527.10 ADV23334.1 - 0.094 12.9 1.4 0.34 11.1 1.4 1.9 1 0 0 1 1 1 0 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter Pns11_12 PF17464.2 ADV23334.1 - 0.34 10.6 0.4 0.51 10.0 0.4 1.2 1 0 0 1 1 1 0 Non-structural protein 11 and 12 Fer2_3 PF13085.6 ADV23335.1 - 6.3e-32 109.8 0.1 9.9e-32 109.2 0.1 1.3 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_17 PF13534.6 ADV23335.1 - 8e-10 39.1 7.9 8e-10 39.1 7.9 2.0 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 ADV23335.1 - 2.4e-07 30.8 4.3 2.4e-07 30.8 4.3 2.1 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 ADV23335.1 - 1.8e-06 28.3 8.8 1.8e-06 28.3 8.8 2.4 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_7 PF12838.7 ADV23335.1 - 0.0025 18.4 6.3 0.0025 18.4 6.3 2.4 2 2 0 2 2 2 1 4Fe-4S dicluster domain Fer2 PF00111.27 ADV23335.1 - 0.033 14.2 1.7 0.033 14.2 1.7 2.2 2 0 0 2 2 2 0 2Fe-2S iron-sulfur cluster binding domain Fer4_9 PF13187.6 ADV23335.1 - 6 7.1 14.6 2 8.7 9.1 2.7 2 1 0 2 2 2 0 4Fe-4S dicluster domain Ldh_1_C PF02866.18 ADV23336.1 - 1.5e-48 164.9 0.0 2.8e-48 164.0 0.0 1.4 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 ADV23336.1 - 1.1e-45 155.1 0.0 1.8e-45 154.5 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 ADV23336.1 - 1.5e-05 24.2 0.0 2e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family THF_DHG_CYH_C PF02882.19 ADV23336.1 - 0.0031 16.8 0.3 0.02 14.2 0.1 2.3 2 1 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DapB_N PF01113.20 ADV23336.1 - 0.0038 17.3 0.3 0.011 15.9 0.0 1.9 2 0 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus Semialdhyde_dh PF01118.24 ADV23336.1 - 0.0052 17.2 0.4 0.033 14.6 0.0 2.2 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain NAD_binding_10 PF13460.6 ADV23336.1 - 0.027 14.4 0.0 0.043 13.7 0.0 1.4 1 0 0 1 1 1 0 NAD(P)H-binding Glyco_hydro_4 PF02056.16 ADV23336.1 - 0.067 12.7 0.1 2.8 7.5 0.1 2.4 1 1 1 2 2 2 0 Family 4 glycosyl hydrolase GPI-anchored PF10342.9 ADV23337.1 - 1.2e-10 42.0 3.8 1.2e-10 42.0 3.8 2.0 2 1 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Macoilin PF09726.9 ADV23337.1 - 1.4 7.4 12.8 1.6 7.2 12.8 1.2 1 0 0 1 1 1 0 Macoilin family Apt1 PF10351.9 ADV23337.1 - 3.5 6.4 11.1 4.1 6.2 11.1 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain SPX PF03105.19 ADV23337.1 - 5.4 6.8 12.1 6.4 6.6 12.1 1.1 1 0 0 1 1 1 0 SPX domain Glyco_hydro_4C PF11975.8 ADV23339.1 - 0.00045 20.3 0.5 0.00086 19.4 0.5 1.3 1 0 0 1 1 1 1 Family 4 glycosyl hydrolase C-terminal domain DUF3915 PF13054.6 ADV23339.1 - 0.15 12.0 1.2 0.31 11.0 1.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Ribosomal_S13_N PF08069.12 ADV23339.1 - 3.7 7.7 5.0 24 5.1 0.0 3.3 3 0 0 3 3 3 0 Ribosomal S13/S15 N-terminal domain Pkinase PF00069.25 ADV23340.1 - 2.8e-34 118.7 0.0 2.8e-23 82.7 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ADV23340.1 - 3.2e-16 59.4 0.0 2.5e-11 43.3 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 ADV23340.1 - 6.7e-06 26.2 1.3 0.00041 20.4 0.0 2.7 3 0 0 3 3 3 1 Phosphotransferase enzyme family Kinase-like PF14531.6 ADV23340.1 - 0.027 13.8 0.1 1.8 7.8 0.0 2.1 2 0 0 2 2 2 0 Kinase-like Haspin_kinase PF12330.8 ADV23340.1 - 0.12 11.3 0.0 0.19 10.6 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain AdoMet_MTase PF07757.13 ADV23341.1 - 3.9e-20 72.3 0.1 1.6e-18 67.1 0.1 2.5 1 1 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase UvdE PF03851.14 ADV23342.1 - 4.8e-80 268.7 0.0 6.6e-80 268.3 0.0 1.2 1 0 0 1 1 1 1 UV-endonuclease UvdE Forkhead PF00250.18 ADV23343.1 - 1.4e-49 166.2 0.0 1.6e-23 82.7 0.0 2.4 2 0 0 2 2 2 2 Forkhead domain DUF3760 PF12586.8 ADV23344.1 - 6.7e-14 51.8 2.6 1.5e-13 50.7 2.6 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3760) RhoGEF PF00621.20 ADV23345.1 - 2e-29 103.1 0.5 4.2e-29 102.1 0.5 1.6 1 0 0 1 1 1 1 RhoGEF domain EF-hand_4 PF12763.7 ADV23345.1 - 3e-19 68.9 0.0 6.9e-19 67.7 0.0 1.5 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand SH3_9 PF14604.6 ADV23345.1 - 1.1e-18 66.8 8.4 1.8e-12 46.9 0.1 3.3 4 0 0 4 4 4 2 Variant SH3 domain SH3_1 PF00018.28 ADV23345.1 - 1.4e-18 66.2 1.7 6.1e-12 45.0 0.1 2.8 2 0 0 2 2 2 2 SH3 domain SH3_2 PF07653.17 ADV23345.1 - 3.4e-11 42.7 0.0 8e-05 22.2 0.0 2.7 2 0 0 2 2 2 2 Variant SH3 domain WH2 PF02205.20 ADV23345.1 - 7.3e-08 32.0 0.8 1.9e-07 30.7 0.8 1.8 1 0 0 1 1 1 1 WH2 motif DUF1720 PF08226.11 ADV23345.1 - 4.1e-06 27.1 28.7 4.1e-06 27.1 28.7 7.4 7 1 2 9 9 5 3 Domain of unknown function (DUF1720) EF-hand_1 PF00036.32 ADV23345.1 - 4.3e-06 25.9 0.4 0.13 11.9 0.0 2.7 2 0 0 2 2 2 2 EF hand PH_13 PF16652.5 ADV23345.1 - 2.1e-05 24.4 0.0 0.0004 20.2 0.0 2.4 1 1 1 2 2 2 1 Pleckstrin homology domain EF-hand_7 PF13499.6 ADV23345.1 - 0.0035 17.7 0.1 0.0035 17.7 0.1 2.4 2 0 0 2 2 1 1 EF-hand domain pair EF-hand_8 PF13833.6 ADV23345.1 - 0.013 15.3 0.2 0.51 10.2 0.0 2.4 1 1 1 2 2 2 0 EF-hand domain pair EF-hand_6 PF13405.6 ADV23345.1 - 0.019 14.9 0.2 1.5 9.0 0.1 2.7 2 0 0 2 2 2 0 EF-hand domain SH3_3 PF08239.11 ADV23345.1 - 0.59 10.5 1.7 2.7 8.4 0.0 2.4 2 0 0 2 2 2 0 Bacterial SH3 domain TMEM174 PF15029.6 ADV23345.1 - 9.5 5.9 6.7 1.7 8.3 0.4 2.4 2 0 0 2 2 2 0 Transmembrane protein 174 DEAD PF00270.29 ADV23346.1 - 3.9e-28 98.4 0.0 1.6e-13 50.8 0.0 2.6 3 0 0 3 3 3 2 DEAD/DEAH box helicase Helicase_C PF00271.31 ADV23346.1 - 5.7e-27 94.3 0.0 1.3e-26 93.2 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 ADV23346.1 - 8.5e-05 22.6 0.0 0.0003 20.9 0.0 1.8 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit T4SS-DNA_transf PF02534.14 ADV23346.1 - 0.014 14.2 0.0 0.021 13.6 0.0 1.2 1 0 0 1 1 1 0 Type IV secretory system Conjugative DNA transfer AAA_22 PF13401.6 ADV23346.1 - 0.13 12.5 0.0 11 6.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain LRR_8 PF13855.6 ADV23347.1 - 1.3e-45 153.0 47.5 1.7e-08 34.1 0.4 9.6 6 3 2 9 9 9 8 Leucine rich repeat LRR_4 PF12799.7 ADV23347.1 - 2.8e-39 132.5 53.3 6.5e-06 26.4 1.4 11.3 10 2 1 12 12 12 9 Leucine Rich repeats (2 copies) PP2C PF00481.21 ADV23347.1 - 1.9e-38 132.6 0.0 3.7e-38 131.6 0.0 1.5 1 0 0 1 1 1 1 Protein phosphatase 2C Guanylate_cyc PF00211.20 ADV23347.1 - 5e-26 91.5 0.0 1.2e-25 90.2 0.0 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain LRR_1 PF00560.33 ADV23347.1 - 1.9e-08 33.7 30.3 1.4 9.7 0.0 13.0 12 1 0 12 12 12 2 Leucine Rich Repeat LRR_9 PF14580.6 ADV23347.1 - 0.00012 21.6 20.5 0.071 12.6 0.1 5.3 3 1 2 5 5 5 4 Leucine-rich repeat LRR_5 PF13306.6 ADV23347.1 - 0.00022 21.2 5.7 0.58 10.1 0.0 3.8 3 1 0 3 3 3 2 BspA type Leucine rich repeat region (6 copies) Ad_cyc_g-alpha PF08509.11 ADV23347.1 - 0.0024 17.6 0.0 0.0071 16.1 0.0 1.7 1 0 0 1 1 1 1 Adenylate cyclase G-alpha binding domain LRR_6 PF13516.6 ADV23347.1 - 0.024 14.7 51.8 3.1 8.1 0.3 13.4 16 0 0 16 16 16 0 Leucine Rich repeat UCH PF00443.29 ADV23348.1 - 1.4e-70 237.8 0.0 2.1e-70 237.2 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ADV23348.1 - 5.7e-12 45.9 0.0 0.00064 19.4 0.0 3.3 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 ADV23348.1 - 0.00043 20.8 0.0 0.0014 19.2 0.0 1.9 1 0 0 1 1 1 1 DUSP domain PhnA_Zn_Ribbon PF08274.12 ADV23348.1 - 0.13 12.3 1.3 4.1 7.4 0.1 2.5 2 0 0 2 2 2 0 PhnA Zinc-Ribbon DAO PF01266.24 ADV23349.1 - 1.3e-37 130.3 0.0 1.6e-37 130.0 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase K_oxygenase PF13434.6 ADV23349.1 - 0.013 14.7 0.3 1.6 7.8 0.0 2.5 3 0 0 3 3 3 0 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_2 PF00890.24 ADV23349.1 - 0.026 13.6 0.0 0.73 8.8 0.0 2.1 2 0 0 2 2 2 0 FAD binding domain NAD_binding_8 PF13450.6 ADV23349.1 - 0.084 13.1 0.1 0.22 11.8 0.1 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 ADV23349.1 - 0.1 11.8 0.1 0.31 10.2 0.0 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase WD40 PF00400.32 ADV23352.1 - 9.2e-23 80.1 10.2 0.00016 22.4 0.0 6.4 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV23352.1 - 1.4e-14 54.1 4.0 6e-06 26.5 0.2 4.3 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ADV23352.1 - 1.6e-05 24.9 0.2 0.00017 21.5 0.1 2.1 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A GlnD_UR_UTase PF08335.11 ADV23352.1 - 0.037 14.1 0.0 0.089 12.9 0.0 1.5 1 0 0 1 1 1 0 GlnD PII-uridylyltransferase mRNA_decap_C PF16741.5 ADV23352.1 - 0.24 10.7 0.1 0.48 9.8 0.1 1.5 1 0 0 1 1 1 0 mRNA-decapping enzyme C-terminus DIL PF01843.19 ADV23353.1 - 1.6e-27 95.8 3.2 3.5e-27 94.7 3.2 1.6 1 0 0 1 1 1 1 DIL domain Ank_2 PF12796.7 ADV23353.1 - 8.2e-07 29.5 0.0 8.1e-06 26.3 0.0 2.7 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.30 ADV23353.1 - 5.8e-06 26.5 0.3 4.2e-05 23.8 0.1 2.5 2 0 0 2 2 2 1 Ankyrin repeat Ank_4 PF13637.6 ADV23353.1 - 6.4e-06 26.6 0.0 0.15 12.6 0.0 3.8 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ADV23353.1 - 1.9e-05 24.6 0.1 0.0027 18.0 0.0 4.0 4 0 0 4 4 4 1 Ankyrin repeat Ank_5 PF13857.6 ADV23353.1 - 8.9e-05 22.7 0.0 0.00053 20.2 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeats (many copies) SRI PF08236.11 ADV23354.1 - 2.8e-19 69.1 10.6 2.8e-19 69.1 10.6 1.9 2 0 0 2 2 2 1 SRI (Set2 Rpb1 interacting) domain SET PF00856.28 ADV23354.1 - 3e-18 66.8 1.9 1.4e-17 64.6 0.1 2.8 2 2 0 2 2 2 1 SET domain AWS PF17907.1 ADV23354.1 - 1.8e-15 56.6 3.9 1.8e-15 56.6 3.9 2.4 3 0 0 3 3 3 1 AWS domain Med26 PF08711.11 ADV23354.1 - 0.063 13.3 0.3 0.2 11.7 0.3 1.9 1 0 0 1 1 1 0 TFIIS helical bundle-like domain Fungal_trans PF04082.18 ADV23355.1 - 5.2e-09 35.5 0.0 1.6e-08 33.9 0.0 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ADV23355.1 - 0.00011 22.3 13.5 0.00019 21.5 13.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TolA_bind_tri PF16331.5 ADV23359.1 - 0.23 11.5 0.0 0.41 10.8 0.0 1.3 1 0 0 1 1 1 0 TolA binding protein trimerisation ERO1 PF04137.15 ADV23360.1 - 1.5e-130 435.5 0.0 1.9e-130 435.2 0.0 1.1 1 0 0 1 1 1 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) Ribosomal_L30_N PF08079.12 ADV23361.1 - 0.81 10.0 9.7 1.8 8.8 9.7 1.5 1 0 0 1 1 1 0 Ribosomal L30 N-terminal domain Pkinase PF00069.25 ADV23362.1 - 7.6e-43 146.8 0.0 1.1e-42 146.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV23362.1 - 4.5e-24 85.1 0.0 1.9e-16 60.1 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase DUF1770 PF08589.10 ADV23362.1 - 0.048 14.6 0.3 0.35 11.9 0.0 2.7 2 0 0 2 2 2 0 Fungal protein of unknown function (DUF1770) RTA1 PF04479.13 ADV23363.1 - 5.7e-26 91.4 2.1 7.7e-26 91.0 2.1 1.3 1 1 0 1 1 1 1 RTA1 like protein YniB PF14002.6 ADV23363.1 - 0.004 16.9 0.0 0.004 16.9 0.0 2.2 2 2 2 4 4 4 1 YniB-like protein FAD_binding_1 PF00667.20 ADV23364.1 - 2.9e-53 180.7 0.0 4.7e-53 180.0 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 ADV23364.1 - 4.2e-06 27.4 0.0 1e-05 26.2 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 ADV23364.1 - 0.00078 19.8 0.0 0.64 10.4 0.0 3.4 3 0 0 3 3 3 2 Oxidoreductase FAD-binding domain Acetyltransf_1 PF00583.25 ADV23365.1 - 1.6e-06 28.3 0.0 1.9e-06 28.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ADV23365.1 - 9.5e-06 25.6 0.0 1.5e-05 25.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ADV23365.1 - 6.6e-05 23.3 0.0 9.8e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain MRP-S33 PF08293.11 ADV23366.1 - 3.1e-16 59.4 3.0 9.3e-14 51.4 3.0 2.3 1 1 0 1 1 1 1 Mitochondrial ribosomal subunit S27 C166 PF17615.2 ADV23366.1 - 0.28 11.3 0.0 0.39 10.9 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function Bax1-I PF01027.20 ADV23367.1 - 7e-51 173.0 27.1 8.5e-51 172.7 27.1 1.1 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 ACPS PF01648.20 ADV23368.1 - 9.5e-12 45.1 0.0 1.6e-11 44.3 0.0 1.4 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily MDM1 PF15501.6 ADV23369.1 - 0.049 12.8 0.1 0.072 12.2 0.1 1.1 1 0 0 1 1 1 0 Nuclear protein MDM1 Mito_carr PF00153.27 ADV23371.1 - 7.8e-40 134.7 8.2 5.3e-15 55.1 0.1 3.9 3 1 0 3 3 3 3 Mitochondrial carrier protein MtrF PF09472.10 ADV23371.1 - 0.18 11.2 2.7 2 7.9 0.1 3.2 3 0 0 3 3 3 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) Pox_Ag35 PF03286.14 ADV23372.1 - 0.26 11.0 10.3 0.07 12.9 1.0 2.5 2 0 0 2 2 2 0 Pox virus Ag35 surface protein Glyco_transf_28 PF03033.20 ADV23373.1 - 2.3e-27 95.7 0.0 4.6e-27 94.7 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain UDPGT PF00201.18 ADV23373.1 - 6.5e-10 38.4 0.0 1.2e-09 37.5 0.0 1.4 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase GRAM PF02893.20 ADV23373.1 - 6.1e-09 35.8 0.0 9.6e-05 22.2 0.0 2.8 3 0 0 3 3 3 2 GRAM domain PH PF00169.29 ADV23373.1 - 0.05 14.1 0.0 0.16 12.5 0.0 1.9 1 0 0 1 1 1 0 PH domain RhoGAP PF00620.27 ADV23374.1 - 2.4e-34 118.4 0.0 5.3e-34 117.2 0.0 1.6 2 0 0 2 2 2 1 RhoGAP domain B9-C2 PF07162.11 ADV23374.1 - 0.11 12.7 0.0 0.6 10.3 0.1 1.9 2 0 0 2 2 2 0 Ciliary basal body-associated, B9 protein Nup192 PF11894.8 ADV23374.1 - 0.14 9.2 0.4 0.19 8.8 0.4 1.0 1 0 0 1 1 1 0 Nuclear pore complex scaffold, nucleoporins 186/192/205 RRM_1 PF00076.22 ADV23375.1 - 5.6e-15 54.9 0.0 8.2e-15 54.4 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.6 ADV23375.1 - 9.8e-05 22.8 6.1 0.0018 18.7 0.1 2.5 2 0 0 2 2 2 2 C-terminal duplication domain of Friend of PRMT1 RRM_occluded PF16842.5 ADV23375.1 - 0.021 14.7 0.0 0.036 13.9 0.0 1.3 1 0 0 1 1 1 0 Occluded RNA-recognition motif Arm-DNA-bind_5 PF17293.2 ADV23375.1 - 0.14 12.6 0.2 0.22 12.0 0.2 1.4 1 0 0 1 1 1 0 Arm DNA-binding domain Arf PF00025.21 ADV23376.1 - 2.4e-79 264.9 0.1 2.7e-79 264.7 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 ADV23376.1 - 5.9e-15 55.2 0.0 7.2e-15 54.9 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 ADV23376.1 - 2.7e-14 53.4 0.0 3.7e-14 53.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 ADV23376.1 - 5.1e-13 48.9 1.3 3.8e-09 36.2 0.2 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 ADV23376.1 - 1.2e-12 47.7 0.0 1.3e-12 47.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 ADV23376.1 - 9.7e-11 41.5 0.0 1.2e-10 41.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ADV23376.1 - 1.6e-06 28.2 0.0 2.6e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 ADV23376.1 - 0.0061 15.9 0.6 0.018 14.3 0.6 1.8 1 1 0 1 1 1 1 6-phosphofructo-2-kinase Rho_N PF07498.12 ADV23377.1 - 8.7e-09 35.2 0.3 1.6e-08 34.3 0.3 1.3 1 0 0 1 1 1 1 Rho termination factor, N-terminal domain SAP PF02037.27 ADV23377.1 - 0.22 11.3 0.3 0.52 10.1 0.1 1.8 2 0 0 2 2 2 0 SAP domain zf-C2H2_jaz PF12171.8 ADV23378.1 - 1.3e-05 25.3 1.2 0.0024 18.1 0.4 2.3 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 ADV23378.1 - 0.00035 21.2 3.3 0.17 12.8 0.2 2.4 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 ADV23378.1 - 0.0011 19.3 2.9 0.21 12.1 0.1 2.4 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-Di19 PF05605.12 ADV23378.1 - 0.93 9.8 4.0 2 8.8 1.6 2.0 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding PyrI_C PF02748.15 ADV23378.1 - 2.7 7.9 4.2 4.1 7.4 0.5 2.2 1 1 1 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain GTP_EFTU PF00009.27 ADV23379.1 - 1.4e-57 194.4 0.1 2e-57 193.9 0.1 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 ADV23379.1 - 2e-28 98.9 0.0 4.1e-28 97.9 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 ADV23379.1 - 4.2e-15 55.9 4.6 4.2e-15 55.9 4.6 1.8 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 ADV23379.1 - 6.6e-05 23.0 0.1 0.00013 22.1 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase cobW PF02492.19 ADV23379.1 - 0.0035 17.0 0.3 0.0086 15.7 0.0 1.8 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain RsgA_GTPase PF03193.16 ADV23379.1 - 0.0058 16.6 0.2 0.025 14.5 0.0 1.8 1 1 1 2 2 2 1 RsgA GTPase PduV-EutP PF10662.9 ADV23379.1 - 0.0075 16.0 0.2 2.5 7.8 0.0 2.3 2 0 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation BRCA-2_OB1 PF09103.10 ADV23380.1 - 2.2e-34 118.0 0.0 3.6e-34 117.3 0.0 1.4 1 0 0 1 1 1 1 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 BRCA-2_helical PF09169.10 ADV23380.1 - 1.1e-05 25.1 0.5 0.072 12.7 1.1 2.5 1 1 1 2 2 2 2 BRCA2, helical Lyase_1 PF00206.20 ADV23381.1 - 1.3e-24 87.2 0.0 1.9e-24 86.6 0.0 1.2 1 0 0 1 1 1 1 Lyase ADSL_C PF10397.9 ADV23381.1 - 1.1e-17 64.3 0.0 2.8e-17 63.0 0.0 1.8 1 0 0 1 1 1 1 Adenylosuccinate lyase C-terminus adh_short_C2 PF13561.6 ADV23382.1 - 6.7e-29 101.1 0.0 7.3e-28 97.7 0.0 2.1 1 1 1 2 2 2 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ADV23382.1 - 9.9e-22 77.3 0.0 1.6e-21 76.6 0.0 1.4 1 1 0 1 1 1 1 short chain dehydrogenase Mito_carr PF00153.27 ADV23383.1 - 6.2e-52 173.5 3.4 3.7e-17 62.0 0.1 4.1 3 1 1 4 4 4 4 Mitochondrial carrier protein Serine_protease PF18405.1 ADV23383.1 - 0.0027 16.9 2.5 0.18 10.9 0.1 2.6 3 0 0 3 3 3 2 Gammaproteobacterial serine protease Smg4_UPF3 PF03467.15 ADV23384.1 - 3.8e-34 118.2 0.2 3.8e-34 118.2 0.2 3.4 3 1 0 3 3 3 1 Smg-4/UPF3 family Presenilin PF01080.17 ADV23384.1 - 6.1 5.5 7.7 7.8 5.1 7.7 1.2 1 0 0 1 1 1 0 Presenilin MIOX PF05153.15 ADV23385.1 - 5.5e-115 383.2 0.3 7.4e-115 382.8 0.3 1.2 1 0 0 1 1 1 1 Myo-inositol oxygenase HD PF01966.22 ADV23385.1 - 0.011 15.9 0.0 0.4 10.9 0.0 2.3 2 0 0 2 2 2 0 HD domain adh_short_C2 PF13561.6 ADV23386.1 - 2.8e-28 99.1 0.1 1.2e-27 97.0 0.1 1.7 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ADV23386.1 - 3.2e-23 82.2 0.1 5.4e-23 81.5 0.1 1.3 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ADV23386.1 - 3.5e-05 23.8 0.0 5.4e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 ADV23386.1 - 0.0073 15.7 0.0 0.012 15.0 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase TrkA_N PF02254.18 ADV23386.1 - 0.022 15.0 0.1 0.035 14.4 0.1 1.3 1 0 0 1 1 1 0 TrkA-N domain Epimerase PF01370.21 ADV23386.1 - 0.062 12.8 0.0 0.11 11.9 0.0 1.5 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ADV23386.1 - 0.079 12.0 0.0 0.11 11.5 0.0 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 ADV23386.1 - 0.2 10.7 0.2 0.33 10.1 0.2 1.5 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein AP_endonuc_2 PF01261.24 ADV23387.1 - 7.9e-22 77.7 0.0 1.5e-21 76.8 0.0 1.4 1 1 0 1 1 1 1 Xylose isomerase-like TIM barrel DHDPS PF00701.22 ADV23388.1 - 4.4e-25 88.0 0.0 1.7e-24 86.1 0.0 1.7 1 1 0 1 1 1 1 Dihydrodipicolinate synthetase family DUF4078 PF13300.6 ADV23389.1 - 4e-13 49.5 17.2 4e-13 49.5 17.2 4.0 4 1 0 4 4 4 1 Domain of unknown function (DUF4078) Ribosomal_L24e PF01246.20 ADV23390.1 - 2.3e-31 107.8 0.8 2.3e-31 107.8 0.8 1.8 2 0 0 2 2 2 1 Ribosomal protein L24e SWIB PF02201.18 ADV23391.1 - 2.8e-12 46.4 0.0 5e-12 45.5 0.0 1.4 1 0 0 1 1 1 1 SWIB/MDM2 domain V-SNARE_C PF12352.8 ADV23392.1 - 2.7e-17 62.8 1.2 2.7e-17 62.8 1.2 1.8 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus TPR_MLP1_2 PF07926.12 ADV23392.1 - 0.0012 18.9 1.2 0.0082 16.2 1.2 2.0 1 1 0 1 1 1 1 TPR/MLP1/MLP2-like protein DUF5082 PF16888.5 ADV23392.1 - 0.013 15.8 0.6 0.16 12.2 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) PEP-utilisers_N PF05524.13 ADV23392.1 - 0.013 15.6 0.9 0.63 10.2 0.8 2.4 1 1 0 1 1 1 0 PEP-utilising enzyme, N-terminal TipAS PF07739.13 ADV23392.1 - 0.036 14.6 0.2 0.1 13.1 0.0 1.7 2 0 0 2 2 2 0 TipAS antibiotic-recognition domain ABC_tran_CTD PF16326.5 ADV23392.1 - 0.04 14.2 2.3 0.082 13.2 0.9 2.0 2 0 0 2 2 2 0 ABC transporter C-terminal domain SF-assemblin PF06705.11 ADV23392.1 - 0.095 12.0 0.1 0.12 11.6 0.1 1.2 1 0 0 1 1 1 0 SF-assemblin/beta giardin DUF5344 PF17279.2 ADV23392.1 - 0.1 13.2 0.3 0.26 11.9 0.2 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5344) Mid2 PF04478.12 ADV23392.1 - 0.11 12.3 0.2 0.26 11.1 0.2 1.5 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor ALMT PF11744.8 ADV23392.1 - 0.17 10.7 0.0 0.23 10.3 0.0 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter Syntaxin-6_N PF09177.11 ADV23392.1 - 0.31 11.6 4.1 0.85 10.2 1.9 2.6 2 1 0 2 2 2 0 Syntaxin 6, N-terminal Peptidase_M24 PF00557.24 ADV23393.1 - 1.2e-42 146.0 0.1 1.6e-42 145.6 0.1 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 CDT1_C PF16679.5 ADV23393.1 - 0.041 14.3 0.0 0.041 14.3 0.0 1.7 2 0 0 2 2 2 0 DNA replication factor Cdt1 C-terminal domain YL1 PF05764.13 ADV23393.1 - 0.56 10.3 12.6 0.9 9.6 12.6 1.2 1 0 0 1 1 1 0 YL1 nuclear protein CDC45 PF02724.14 ADV23393.1 - 1.4 7.1 7.8 2 6.6 7.8 1.2 1 0 0 1 1 1 0 CDC45-like protein Menin PF05053.13 ADV23393.1 - 6.5 5.0 5.7 8.5 4.6 5.7 1.1 1 0 0 1 1 1 0 Menin WGG PF10273.9 ADV23394.1 - 6.3e-25 87.7 0.0 1.1e-24 86.8 0.0 1.4 1 0 0 1 1 1 1 Pre-rRNA-processing protein TSR2 RRP7 PF12923.7 ADV23394.1 - 0.0073 16.4 0.2 0.015 15.4 0.2 1.5 1 0 0 1 1 1 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain RRM_1 PF00076.22 ADV23397.1 - 7.1e-06 25.8 0.0 1.2e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PUF PF00806.19 ADV23398.1 - 5.9e-09 35.1 0.5 0.045 13.4 0.0 5.2 5 0 0 5 5 5 3 Pumilio-family RNA binding repeat GRASP55_65 PF04495.14 ADV23399.1 - 5.2e-53 179.0 0.0 4.5e-48 163.1 0.0 2.2 1 1 1 2 2 2 2 GRASP55/65 PDZ-like domain PDZ_6 PF17820.1 ADV23399.1 - 4.8e-07 29.5 0.0 1.4e-06 28.0 0.0 1.8 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 ADV23399.1 - 0.0021 18.3 0.0 0.021 15.1 0.0 2.1 2 0 0 2 2 2 1 PDZ domain Tricorn_PDZ PF14685.6 ADV23399.1 - 0.13 12.3 0.0 0.55 10.2 0.0 1.9 2 0 0 2 2 2 0 Tricorn protease PDZ domain Pkinase PF00069.25 ADV23400.1 - 5.2e-70 235.8 0.0 6.6e-70 235.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV23400.1 - 2e-51 174.7 0.0 2.7e-51 174.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ADV23400.1 - 1.2e-05 24.4 0.0 1.8e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 ADV23400.1 - 0.00019 20.9 0.0 0.002 17.5 0.0 2.3 2 0 0 2 2 2 1 Kinase-like DUF1241 PF06840.11 ADV23400.1 - 0.00098 18.8 0.0 0.0023 17.6 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1241) Haspin_kinase PF12330.8 ADV23400.1 - 0.0087 15.0 0.0 1.1 8.1 0.0 2.1 2 0 0 2 2 2 2 Haspin like kinase domain APH PF01636.23 ADV23400.1 - 0.035 14.0 0.0 0.11 12.4 0.0 1.7 1 1 1 2 2 2 0 Phosphotransferase enzyme family Serinc PF03348.15 ADV23401.1 - 3.4e-150 500.7 7.0 4e-150 500.5 7.0 1.0 1 0 0 1 1 1 1 Serine incorporator (Serinc) PGF-CTERM PF18204.1 ADV23401.1 - 3.6 7.7 8.5 1.6 8.8 1.0 3.3 2 0 0 2 2 2 0 PGF-CTERM motif EMP24_GP25L PF01105.24 ADV23402.1 - 5.1e-43 147.1 0.0 6.5e-43 146.8 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF2569 PF10754.9 ADV23402.1 - 0.046 14.2 0.3 0.046 14.2 0.3 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2569) RRP36 PF06102.12 ADV23403.1 - 4.8e-43 147.0 22.3 4.8e-43 147.0 22.3 2.0 2 0 0 2 2 2 1 rRNA biogenesis protein RRP36 RRM_1 PF00076.22 ADV23404.1 - 9.1e-23 79.9 0.0 1.3e-22 79.4 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ADV23404.1 - 0.0021 17.7 0.0 0.0032 17.1 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ADV23404.1 - 0.068 13.3 0.0 0.12 12.6 0.0 1.4 1 1 0 1 1 1 0 RNA recognition motif RRM_8 PF11835.8 ADV23404.1 - 0.12 12.6 0.0 0.18 12.0 0.0 1.3 1 0 0 1 1 1 0 RRM-like domain Zn_clus PF00172.18 ADV23405.1 - 0.0001 22.4 8.9 0.00024 21.2 8.9 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain LytB_WW PF18342.1 ADV23405.1 - 0.15 12.2 0.1 1.2 9.3 0.1 2.2 2 0 0 2 2 2 0 Endo-beta-N-acetylglucosaminidase LytB WW domain Sugar_tr PF00083.24 ADV23406.1 - 2.7e-93 313.3 23.7 3.2e-93 313.0 23.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ADV23406.1 - 2.7e-28 98.9 28.2 2.7e-28 98.9 28.2 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 ADV23406.1 - 1.1e-07 30.7 1.4 1.1e-07 30.7 1.4 1.6 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) DUF2178 PF09946.9 ADV23406.1 - 0.59 10.3 0.0 0.59 10.3 0.0 3.1 3 1 0 3 3 3 0 Predicted membrane protein (DUF2178) Acyl-CoA_dh_N PF02771.16 ADV23407.1 - 9.3e-28 97.2 0.0 1.7e-27 96.3 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 ADV23407.1 - 1.1e-24 86.4 0.0 2e-24 85.6 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 ADV23407.1 - 1e-23 84.2 0.0 1.5e-23 83.6 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_2 PF08028.11 ADV23407.1 - 3.3e-06 27.4 0.2 4e-05 23.9 0.2 2.2 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.8 ADV23407.1 - 0.081 12.6 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase N terminal Bromodomain PF00439.25 ADV23408.1 - 2.2e-54 181.5 0.0 7.5e-20 70.8 0.0 3.8 3 0 0 3 3 3 3 Bromodomain HEAT_2 PF13646.6 ADV23408.1 - 0.0031 17.9 0.0 0.66 10.4 0.0 3.8 3 0 0 3 3 3 1 HEAT repeats RusA PF05866.11 ADV23408.1 - 0.083 13.4 0.4 1.2 9.7 0.0 2.5 2 0 0 2 2 2 0 Endodeoxyribonuclease RusA WD40 PF00400.32 ADV23409.1 - 1.6e-43 145.8 20.8 8.1e-08 32.8 0.3 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.8 ADV23409.1 - 1.2e-06 27.5 0.2 0.0082 14.8 0.0 3.5 3 1 1 4 4 4 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ADV23409.1 - 2.2e-05 24.7 0.3 0.22 11.9 0.0 4.5 1 1 2 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ADV23409.1 - 0.025 13.9 0.0 0.081 12.2 0.0 1.9 2 0 0 2 2 2 0 WD40-like domain Aldedh PF00171.22 ADV23410.1 - 4.9e-110 368.2 0.0 5.9e-110 367.9 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Pmp3 PF01679.17 ADV23411.1 - 1.9e-22 79.2 10.3 2.2e-22 79.0 10.3 1.1 1 0 0 1 1 1 1 Proteolipid membrane potential modulator DUF382 PF04037.13 ADV23412.1 - 1.3e-57 193.4 0.1 3.8e-57 191.9 0.1 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF382) PSP PF04046.16 ADV23412.1 - 3.7e-18 65.1 4.0 8.4e-18 64.0 4.0 1.6 1 0 0 1 1 1 1 PSP Ldh_1_N PF00056.23 ADV23413.1 - 4.1e-42 143.6 0.0 6.3e-42 143.0 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 ADV23413.1 - 6.8e-41 140.0 0.2 9.2e-41 139.6 0.2 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain 3Beta_HSD PF01073.19 ADV23413.1 - 0.0027 16.8 0.0 0.0037 16.3 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Glyco_hydro_4 PF02056.16 ADV23413.1 - 0.072 12.6 0.2 0.92 9.0 0.1 2.2 1 1 1 2 2 2 0 Family 4 glycosyl hydrolase GCIP PF13324.6 ADV23414.1 - 1.6e-20 73.8 1.2 1.9e-20 73.6 1.2 1.1 1 0 0 1 1 1 1 Grap2 and cyclin-D-interacting Toluene_X PF03349.16 ADV23414.1 - 0.073 11.6 1.1 4 5.9 0.1 2.1 2 0 0 2 2 2 0 Outer membrane protein transport protein (OMPP1/FadL/TodX) Inositol_P PF00459.25 ADV23415.1 - 2.1e-61 207.8 0.0 2.4e-61 207.7 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family Ribosomal_L6 PF00347.23 ADV23416.1 - 1.1e-19 70.8 0.0 2.2e-12 47.5 0.0 2.8 3 0 0 3 3 3 2 Ribosomal protein L6 PBP PF01161.20 ADV23416.1 - 0.064 13.6 0.0 10 6.4 0.0 2.2 1 1 1 2 2 2 0 Phosphatidylethanolamine-binding protein Pkinase PF00069.25 ADV23417.1 - 4.2e-43 147.6 0.0 2.3e-42 145.2 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV23417.1 - 1.8e-18 66.8 0.0 1e-13 51.2 0.0 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 ADV23417.1 - 0.00042 19.7 0.0 0.13 11.5 0.0 2.4 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 ADV23417.1 - 0.013 15.4 0.7 0.28 11.1 0.3 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family PIRT PF15099.6 ADV23417.1 - 0.076 12.6 0.0 0.16 11.6 0.0 1.5 1 0 0 1 1 1 0 Phosphoinositide-interacting protein family DUF4468 PF14730.6 ADV23419.1 - 0.013 15.8 0.1 0.022 15.1 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4468) with TBP-like fold CDH PF02611.15 ADV23419.1 - 0.051 13.2 0.2 0.066 12.8 0.2 1.4 1 1 0 1 1 1 0 CDP-diacylglycerol pyrophosphatase DUF202 PF02656.15 ADV23420.1 - 3e-11 43.6 6.4 1.2e-10 41.7 3.6 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF202) DUF4383 PF14325.6 ADV23420.1 - 0.036 14.3 2.2 0.078 13.3 0.4 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4383) Polysacc_synt_C PF14667.6 ADV23420.1 - 0.23 11.5 4.6 2 8.5 0.9 2.1 1 1 0 2 2 2 0 Polysaccharide biosynthesis C-terminal domain RTC PF01137.21 ADV23422.1 - 1.4e-50 171.6 0.0 1.6e-50 171.4 0.0 1.0 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.13 ADV23422.1 - 1.6e-34 118.5 0.0 2.4e-34 117.9 0.0 1.3 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain G6PD_C PF02781.16 ADV23423.1 - 5.3e-111 370.5 0.0 7.9e-111 369.9 0.0 1.3 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 ADV23423.1 - 8.5e-59 199.1 0.1 1.4e-58 198.4 0.1 1.4 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain Glyco_hydro_47 PF01532.20 ADV23425.1 - 1.4e-149 498.9 0.0 1.7e-149 498.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Glyco_hydro_76 PF03663.14 ADV23425.1 - 0.036 13.6 0.0 3.2 7.2 0.0 2.2 2 0 0 2 2 2 0 Glycosyl hydrolase family 76 Glyco_hydro_127 PF07944.12 ADV23425.1 - 0.064 11.7 0.0 0.41 9.1 0.0 2.0 2 0 0 2 2 2 0 Beta-L-arabinofuranosidase, GH127 AMMECR1 PF01871.17 ADV23426.1 - 8.5e-43 145.8 0.0 1.1e-42 145.5 0.0 1.1 1 0 0 1 1 1 1 AMMECR1 efThoc1 PF11957.8 ADV23427.1 - 5.8e-114 381.5 0.1 5.8e-114 381.5 0.1 1.8 2 0 0 2 2 2 1 THO complex subunit 1 transcription elongation factor PT PF04886.12 ADV23427.1 - 0.15 11.7 6.1 0.27 10.8 6.1 1.4 1 0 0 1 1 1 0 PT repeat Adaptin_N PF01602.20 ADV23428.1 - 2e-94 317.0 7.0 3.3e-94 316.3 7.0 1.2 1 0 0 1 1 1 1 Adaptin N terminal region Coatomer_b_Cpla PF14806.6 ADV23428.1 - 3.8e-55 185.3 0.0 1.2e-54 183.7 0.0 1.9 1 0 0 1 1 1 1 Coatomer beta subunit appendage platform Coatamer_beta_C PF07718.12 ADV23428.1 - 4e-54 182.3 0.1 9.6e-54 181.1 0.1 1.7 1 0 0 1 1 1 1 Coatomer beta C-terminal region HEAT_2 PF13646.6 ADV23428.1 - 2.5e-11 43.8 1.0 0.00031 21.1 0.0 4.8 2 1 1 4 4 4 2 HEAT repeats Cnd1 PF12717.7 ADV23428.1 - 3e-10 40.4 4.8 9.2e-07 29.0 0.1 3.5 2 1 1 3 3 3 3 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 ADV23428.1 - 1.4e-08 34.2 0.3 0.019 15.2 0.0 5.5 4 1 1 5 5 5 2 HEAT repeat Coatomer_g_Cpla PF16381.5 ADV23428.1 - 1.5e-05 25.1 0.0 5.9e-05 23.2 0.0 2.1 2 0 0 2 2 2 1 Coatomer subunit gamma-1 C-terminal appendage platform HEAT_EZ PF13513.6 ADV23428.1 - 0.0012 19.3 0.8 20 5.8 0.0 5.4 3 2 0 4 4 4 0 HEAT-like repeat DUF5578 PF17741.1 ADV23428.1 - 0.0062 16.0 4.3 0.16 11.4 0.7 3.3 3 1 1 4 4 4 1 Family of unknown function (DUF5578) DNA_alkylation PF08713.11 ADV23428.1 - 0.012 15.4 0.3 3.8 7.2 0.0 3.4 2 1 0 3 3 3 0 DNA alkylation repair enzyme ParcG PF10274.9 ADV23428.1 - 0.013 15.6 2.9 0.11 12.6 0.1 3.3 2 1 0 3 3 3 0 Parkin co-regulated protein DUF5071 PF16804.5 ADV23428.1 - 0.12 12.6 0.8 1.7 8.9 0.0 3.2 3 1 1 4 4 4 0 Domain of unknown function (DUF5071) Nop52 PF05997.12 ADV23429.1 - 2.1e-69 233.6 0.0 2.8e-69 233.2 0.0 1.2 1 0 0 1 1 1 1 Nucleolar protein,Nop52 TMEM52 PF14979.6 ADV23429.1 - 0.045 13.7 0.2 0.071 13.0 0.2 1.2 1 0 0 1 1 1 0 Transmembrane 52 LTV PF04180.14 ADV23430.1 - 9.2e-92 308.7 19.9 1.7e-91 307.8 15.6 2.0 1 1 0 1 1 1 1 Low temperature viability protein DUF4407 PF14362.6 ADV23430.1 - 0.072 12.4 2.3 0.19 11.1 2.3 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Ribosomal_S27e PF01667.17 ADV23431.1 - 1e-28 98.8 6.2 1.2e-28 98.5 6.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S27 Hormone_6 PF00236.18 ADV23431.1 - 0.028 14.4 1.7 0.041 13.9 1.7 1.3 1 0 0 1 1 1 0 Glycoprotein hormone V-SNARE PF05008.15 ADV23432.1 - 9.4e-20 70.8 2.3 2.1e-19 69.6 2.3 1.6 1 0 0 1 1 1 1 Vesicle transport v-SNARE protein N-terminus V-SNARE_C PF12352.8 ADV23432.1 - 6e-11 42.5 12.0 7.7e-11 42.1 1.1 3.7 3 1 1 4 4 4 1 Snare region anchored in the vesicle membrane C-terminus Exonuc_VII_L PF02601.15 ADV23432.1 - 0.0024 17.5 0.3 0.0031 17.1 0.3 1.2 1 0 0 1 1 1 1 Exonuclease VII, large subunit DUF1351 PF07083.11 ADV23432.1 - 0.03 14.1 0.3 0.05 13.4 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1351) Laminin_II PF06009.12 ADV23432.1 - 0.1 12.6 3.0 0.34 10.9 1.5 2.0 2 0 0 2 2 2 0 Laminin Domain II OmpH PF03938.14 ADV23432.1 - 0.38 11.1 3.9 3.5 8.0 3.9 2.1 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) HR1 PF02185.16 ADV23432.1 - 1.5 9.0 7.3 18 5.5 7.3 2.5 1 1 0 1 1 1 0 Hr1 repeat CCDC-167 PF15188.6 ADV23432.1 - 3.7 8.0 7.0 3.1 8.2 2.0 3.1 2 2 1 3 3 3 0 Coiled-coil domain-containing protein 167 Methyltransf_16 PF10294.9 ADV23433.1 - 4.5e-20 72.1 0.0 6.5e-20 71.6 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase GidB PF02527.15 ADV23433.1 - 0.00012 21.5 0.0 0.00018 20.9 0.0 1.2 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G PrmA PF06325.13 ADV23433.1 - 0.033 13.6 0.0 0.042 13.2 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 ADV23433.1 - 0.036 14.8 0.1 0.09 13.5 0.1 1.7 1 1 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 ADV23433.1 - 0.18 11.4 0.0 0.25 10.9 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain NNMT_PNMT_TEMT PF01234.17 ADV23433.1 - 0.21 10.7 0.0 0.31 10.2 0.0 1.1 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family Rho_GDI PF02115.17 ADV23435.1 - 4.4e-55 186.5 0.0 5.8e-55 186.1 0.0 1.0 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor Adap_comp_sub PF00928.21 ADV23436.1 - 2e-91 306.1 0.0 4.4e-91 304.9 0.0 1.5 2 0 0 2 2 2 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 ADV23436.1 - 4.4e-06 26.7 0.4 7.6e-06 25.9 0.4 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain muHD PF10291.9 ADV23436.1 - 0.0023 17.4 0.0 0.0039 16.7 0.0 1.3 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain NTP_transferase PF00483.23 ADV23437.1 - 1.2e-31 110.2 0.0 2.6e-31 109.1 0.0 1.5 1 1 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.24 ADV23437.1 - 3.8e-09 35.9 1.8 2.6e-06 26.9 0.1 2.6 1 1 1 2 2 2 2 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 ADV23437.1 - 4.1e-08 33.8 0.0 5.6e-08 33.3 0.0 1.4 1 0 0 1 1 1 1 MobA-like NTP transferase domain IspD PF01128.19 ADV23437.1 - 0.01 15.6 0.0 0.024 14.4 0.0 1.5 1 0 0 1 1 1 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Hexapep_2 PF14602.6 ADV23437.1 - 0.013 15.3 2.2 0.07 12.9 0.1 2.8 3 0 0 3 3 3 0 Hexapeptide repeat of succinyl-transferase Ntox30 PF15532.6 ADV23437.1 - 0.021 15.2 0.1 0.072 13.5 0.0 1.9 2 0 0 2 2 2 0 Bacterial toxin 30 CTP_transf_3 PF02348.19 ADV23437.1 - 0.12 12.3 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 Cytidylyltransferase DUF4954 PF16314.5 ADV23437.1 - 0.16 10.1 0.0 0.22 9.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4954) ChAPs PF09295.10 ADV23439.1 - 4.7e-161 536.2 1.3 7e-161 535.6 0.0 1.8 2 1 0 2 2 2 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_19 PF14559.6 ADV23439.1 - 1.6e-07 31.7 3.2 0.0075 16.8 0.1 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ADV23439.1 - 6.7e-06 25.9 3.9 0.18 12.1 0.1 4.9 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 ADV23439.1 - 9e-05 22.3 3.4 0.077 13.1 0.2 5.2 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_15 PF13429.6 ADV23439.1 - 0.00054 19.3 5.4 0.099 11.8 0.7 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 ADV23439.1 - 0.028 15.0 4.1 36 5.3 0.0 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.6 ADV23439.1 - 0.037 14.8 7.5 44 5.3 0.1 5.7 2 2 4 6 6 6 0 Tetratricopeptide repeat TPR_1 PF00515.28 ADV23439.1 - 0.071 13.0 0.4 2.2 8.2 0.1 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.6 ADV23439.1 - 0.24 11.8 0.7 34 5.1 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 ADV23439.1 - 0.28 11.3 1.7 24 5.3 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat ING PF12998.7 ADV23441.1 - 4.4e-14 52.9 0.0 1.8e-05 25.3 0.1 2.4 2 0 0 2 2 2 2 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 ADV23441.1 - 9.6e-05 22.2 5.3 0.00017 21.4 5.3 1.4 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 ADV23441.1 - 0.0082 15.7 0.4 0.016 14.7 0.4 1.5 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.6 ADV23441.1 - 0.053 13.8 0.3 0.12 12.7 0.3 1.6 1 0 0 1 1 1 0 PHD-like zinc-binding domain PS_Dcarbxylase PF02666.15 ADV23442.1 - 2.3e-72 242.8 0.0 5.1e-71 238.4 0.0 2.1 1 1 0 1 1 1 1 Phosphatidylserine decarboxylase Borealin PF10512.9 ADV23442.1 - 0.048 13.6 0.1 0.086 12.8 0.1 1.4 1 0 0 1 1 1 0 Cell division cycle-associated protein 8 Pribosyltran_N PF13793.6 ADV23443.1 - 8.8e-45 151.4 0.1 2.1e-43 147.0 0.1 2.2 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 ADV23443.1 - 9.1e-42 143.2 2.7 1.8e-35 122.7 0.3 2.6 2 1 1 3 3 3 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 ADV23443.1 - 1.9e-13 50.3 0.3 5.7e-13 48.7 0.2 1.8 2 0 0 2 2 2 1 Phosphoribosyl transferase domain Fungal_trans PF04082.18 ADV23444.1 - 1.7e-18 66.6 0.0 2.5e-18 66.1 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ADV23444.1 - 0.00062 19.8 5.6 0.0012 18.9 5.6 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Prot_inhib_II PF02428.15 ADV23444.1 - 8.3 6.9 7.4 31 5.1 6.6 2.3 2 1 1 3 3 3 0 Potato type II proteinase inhibitor family WW PF00397.26 ADV23445.1 - 7.9e-08 32.3 7.6 2.4e-07 30.7 7.6 1.9 1 0 0 1 1 1 1 WW domain WD40 PF00400.32 ADV23446.1 - 9.5e-05 23.1 1.8 0.068 14.1 0.1 4.1 4 1 0 4 4 4 2 WD domain, G-beta repeat ATXN-1_C PF12547.8 ADV23446.1 - 0.13 12.7 1.7 0.37 11.2 1.7 1.8 1 0 0 1 1 1 0 Capicua transcriptional repressor modulator Ribosomal_S9 PF00380.19 ADV23448.1 - 1.8e-38 131.7 0.0 3.3e-38 130.9 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S9/S16 T7SS_ESX_EspC PF10824.8 ADV23448.1 - 0.13 12.7 1.6 0.65 10.5 0.1 2.3 2 0 0 2 2 2 0 Excreted virulence factor EspC, type VII ESX diderm Response_reg PF00072.24 ADV23449.1 - 4.6e-46 155.6 5.4 3.1e-26 91.7 0.1 2.5 2 0 0 2 2 2 2 Response regulator receiver domain HATPase_c PF02518.26 ADV23449.1 - 7.5e-37 126.3 0.8 5.6e-18 65.5 0.0 2.6 2 0 0 2 2 2 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_8 PF13188.7 ADV23449.1 - 3e-08 33.5 0.0 4.6e-07 29.7 0.0 2.9 3 0 0 3 3 3 1 PAS domain HisKA PF00512.25 ADV23449.1 - 3.2e-08 33.5 0.6 1.6e-05 24.8 0.0 3.0 2 0 0 2 2 2 2 His Kinase A (phospho-acceptor) domain PAS PF00989.25 ADV23449.1 - 0.00017 21.5 0.0 0.0016 18.4 0.0 2.7 3 0 0 3 3 3 1 PAS fold HATPase_c_3 PF13589.6 ADV23449.1 - 0.0016 18.3 0.0 1.2 9.0 0.0 2.6 2 0 0 2 2 2 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_9 PF13426.7 ADV23449.1 - 0.0065 16.7 0.0 0.07 13.4 0.0 2.9 2 0 0 2 2 2 1 PAS domain Lactamase_B PF00753.27 ADV23451.1 - 3e-15 56.8 0.7 2.7e-12 47.1 1.7 3.2 2 1 0 2 2 2 1 Metallo-beta-lactamase superfamily BLACT_WH PF17778.1 ADV23451.1 - 1.3e-08 34.7 0.1 1.3e-08 34.7 0.1 2.0 2 0 0 2 2 2 1 Beta-lactamase associated winged helix domain Lactamase_B_2 PF12706.7 ADV23451.1 - 0.00052 19.6 0.9 0.0028 17.2 0.9 2.2 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_6 PF16661.5 ADV23451.1 - 0.096 12.1 0.0 0.19 11.2 0.0 1.4 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily domain PRELI PF04707.14 ADV23452.1 - 1.2e-14 54.5 0.0 3.1e-14 53.1 0.0 1.6 2 0 0 2 2 2 1 PRELI-like family SCAMP PF04144.13 ADV23452.1 - 4.9e-11 43.2 0.0 6.6e-11 42.8 0.0 1.2 1 0 0 1 1 1 1 SCAMP family zf-H2C2_2 PF13465.6 ADV23453.1 - 2.8e-18 65.4 20.3 6e-07 29.6 1.5 5.3 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2 PF00096.26 ADV23453.1 - 7.3e-18 63.9 29.9 7.3e-05 23.0 0.5 5.4 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ADV23453.1 - 1.5e-06 28.5 30.9 0.085 13.7 0.4 5.6 6 0 0 6 6 6 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 ADV23453.1 - 0.00012 22.3 3.7 0.29 11.5 0.2 4.4 4 0 0 4 4 4 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 ADV23453.1 - 0.065 13.6 13.3 0.37 11.3 1.1 4.8 5 0 0 5 5 5 0 Zinc-finger of C2H2 type zf-TRAF PF02176.18 ADV23453.1 - 1.7 9.4 7.8 0.17 12.6 0.6 2.5 1 1 2 3 3 3 0 TRAF-type zinc finger BolA PF01722.18 ADV23453.1 - 5.6 7.3 6.9 6 7.2 0.5 3.4 4 0 0 4 4 4 0 BolA-like protein zf-C2H2_11 PF16622.5 ADV23453.1 - 7.1 6.5 8.2 0.31 10.8 0.8 2.6 3 0 0 3 3 3 0 zinc-finger C2H2-type CLASP_N PF12348.8 ADV23454.1 - 4.5e-18 65.6 0.1 1.4e-07 31.4 0.0 5.0 5 0 0 5 5 5 2 CLASP N terminal HEAT PF02985.22 ADV23454.1 - 8.4e-13 47.4 8.2 0.0023 18.0 0.0 9.6 10 0 0 10 10 10 2 HEAT repeat HEAT_2 PF13646.6 ADV23454.1 - 1.9e-06 28.1 9.4 0.44 11.0 0.0 8.6 5 2 1 7 7 7 1 HEAT repeats Cnd1 PF12717.7 ADV23454.1 - 2.5e-06 27.6 0.1 6 6.9 0.0 5.5 5 1 0 5 5 5 3 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 ADV23454.1 - 2e-05 25.0 3.1 0.052 14.1 0.0 7.0 5 0 0 5 5 5 1 HEAT-like repeat Vac14_Fab1_bd PF12755.7 ADV23454.1 - 2.8e-05 24.6 0.0 39 4.9 0.0 7.1 6 1 1 7 7 7 0 Vacuolar 14 Fab1-binding region TAN PF11640.8 ADV23454.1 - 3.5e-05 24.0 1.8 0.0052 16.9 0.3 4.7 5 1 0 5 5 5 1 Telomere-length maintenance and DNA damage repair IFRD PF05004.13 ADV23454.1 - 0.0032 16.6 1.9 0.81 8.7 0.0 4.0 4 0 0 4 4 4 1 Interferon-related developmental regulator (IFRD) Adaptin_N PF01602.20 ADV23454.1 - 0.02 13.5 1.9 2 6.9 0.0 4.4 6 1 0 6 6 6 0 Adaptin N terminal region Pkinase PF00069.25 ADV23455.1 - 1e-43 149.7 0.0 4.3e-43 147.6 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV23455.1 - 2.2e-22 79.6 0.0 2.3e-19 69.7 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase HMG_box PF00505.19 ADV23456.1 - 3.5e-13 49.7 1.2 8.6e-13 48.5 1.2 1.7 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ADV23456.1 - 0.01 16.4 0.2 0.037 14.6 0.2 2.0 1 0 0 1 1 1 0 HMG-box domain Ribosomal_L12 PF00542.19 ADV23456.1 - 7.7 6.9 8.8 0.6 10.5 0.7 2.7 3 0 0 3 3 3 0 Ribosomal protein L7/L12 C-terminal domain EF-hand_7 PF13499.6 ADV23457.1 - 4.2e-22 78.4 1.3 6.4e-19 68.2 1.4 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 ADV23457.1 - 7.7e-18 62.7 4.7 3.2e-08 32.6 0.0 3.8 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 ADV23457.1 - 8.9e-14 50.2 1.2 5.3e-05 22.8 0.0 3.8 4 0 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.6 ADV23457.1 - 3.3e-10 39.0 0.8 0.0013 18.1 0.0 3.4 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 ADV23457.1 - 1.8e-08 34.1 1.4 0.011 15.6 0.4 3.2 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_4 PF12763.7 ADV23457.1 - 8.2e-05 22.5 0.8 0.0099 15.8 0.1 2.3 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 ADV23457.1 - 0.00013 22.2 0.3 0.012 16.0 0.4 2.4 2 1 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region Caleosin PF05042.13 ADV23457.1 - 0.066 13.1 0.4 13 5.7 0.0 2.7 3 0 0 3 3 3 0 Caleosin related protein PMBR PF09373.10 ADV23457.1 - 0.084 13.1 0.1 78 3.7 0.1 3.4 3 0 0 3 3 3 0 Pseudomurein-binding repeat Dockerin_1 PF00404.18 ADV23457.1 - 0.12 12.6 0.2 0.4 10.9 0.2 1.8 1 1 0 1 1 1 0 Dockerin type I domain PRK PF00485.18 ADV23458.1 - 2.6e-51 174.2 0.0 5.6e-51 173.1 0.0 1.5 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family UPRTase PF14681.6 ADV23458.1 - 9e-46 155.9 0.0 1.7e-45 155.0 0.0 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase AAA_18 PF13238.6 ADV23458.1 - 1.3e-05 25.8 0.0 3.5e-05 24.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain CPT PF07931.12 ADV23458.1 - 0.0026 17.6 0.1 0.0083 16.0 0.1 1.9 1 1 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein AAA_33 PF13671.6 ADV23458.1 - 0.013 15.6 0.0 0.031 14.4 0.0 1.7 1 1 0 1 1 1 0 AAA domain CoaE PF01121.20 ADV23458.1 - 0.019 14.7 0.9 0.75 9.4 0.2 2.3 2 0 0 2 2 2 0 Dephospho-CoA kinase Zeta_toxin PF06414.12 ADV23458.1 - 0.035 13.4 0.0 0.082 12.2 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin dNK PF01712.19 ADV23458.1 - 0.037 13.9 0.1 0.14 12.0 0.1 2.0 1 1 0 1 1 1 0 Deoxynucleoside kinase AAA_17 PF13207.6 ADV23458.1 - 0.099 13.1 0.5 0.84 10.1 0.5 2.4 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 ADV23458.1 - 0.12 12.9 0.0 2.7 8.5 0.0 2.3 2 0 0 2 2 2 0 ABC transporter PGK PF00162.19 ADV23462.1 - 1.1e-148 495.2 0.1 1.3e-148 495.0 0.1 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase DASH_Spc34 PF08657.10 ADV23463.1 - 5.7e-06 26.3 0.0 0.033 14.0 0.0 2.2 1 1 1 2 2 2 2 DASH complex subunit Spc34 Sld5 PF05916.11 ADV23464.1 - 3.9e-07 30.5 0.3 7e-07 29.7 0.3 1.3 1 0 0 1 1 1 1 GINS complex protein SLD5_C PF16922.5 ADV23464.1 - 0.00034 20.7 0.0 0.00084 19.5 0.0 1.7 1 0 0 1 1 1 1 DNA replication complex GINS protein SLD5 C-terminus Copper-fist PF00649.18 ADV23465.1 - 3.2e-21 74.5 1.1 3.2e-21 74.5 1.1 2.3 2 1 1 3 3 3 1 Copper fist DNA binding domain WD40 PF00400.32 ADV23466.1 - 4.2e-33 112.8 8.3 6e-08 33.2 0.2 7.6 8 0 0 8 8 8 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV23466.1 - 5.7e-11 42.6 0.1 0.04 14.2 0.0 4.4 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ADV23466.1 - 0.04 13.2 0.0 2.4 7.4 0.0 2.7 3 0 0 3 3 3 0 WD40-like domain zf-MYND PF01753.18 ADV23467.1 - 2.3e-08 34.0 16.6 4.6e-08 33.0 16.6 1.5 1 0 0 1 1 1 1 MYND finger AAA_2 PF07724.14 ADV23468.1 - 1.8e-47 161.6 0.0 1.8e-45 155.1 0.0 2.6 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 ADV23468.1 - 9.8e-33 112.2 7.2 7.2e-32 109.4 0.4 2.7 1 1 1 2 2 2 1 AAA lid domain AAA PF00004.29 ADV23468.1 - 3.7e-19 69.5 0.0 6.6e-09 36.3 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 ADV23468.1 - 1e-17 63.9 0.9 2.1e-17 62.9 0.1 2.1 2 0 0 2 2 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.14 ADV23468.1 - 5.9e-17 62.0 0.2 1.4e-12 47.7 0.0 3.1 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ADV23468.1 - 4.1e-11 43.6 6.6 0.00028 21.3 0.1 4.7 3 2 1 5 5 5 2 AAA ATPase domain Sigma54_activat PF00158.26 ADV23468.1 - 4.5e-09 36.2 0.1 7.9e-08 32.2 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_22 PF13401.6 ADV23468.1 - 1.8e-07 31.5 0.2 0.013 15.8 0.0 3.8 2 2 0 2 2 2 2 AAA domain AAA_18 PF13238.6 ADV23468.1 - 2.5e-05 24.8 0.0 0.21 12.1 0.0 3.0 2 0 0 2 2 2 2 AAA domain ATPase_2 PF01637.18 ADV23468.1 - 4.2e-05 23.6 6.9 1.3 8.9 0.1 4.6 4 1 1 5 5 5 2 ATPase domain predominantly from Archaea IstB_IS21 PF01695.17 ADV23468.1 - 5.4e-05 23.0 0.0 0.15 11.8 0.0 3.2 3 0 0 3 3 3 1 IstB-like ATP binding protein AAA_14 PF13173.6 ADV23468.1 - 9.1e-05 22.5 0.0 0.27 11.3 0.0 3.0 2 0 0 2 2 2 2 AAA domain AAA_24 PF13479.6 ADV23468.1 - 0.00012 21.8 0.0 0.0021 17.8 0.0 2.4 3 0 0 3 3 2 1 AAA domain AAA_7 PF12775.7 ADV23468.1 - 0.00017 21.2 0.0 0.043 13.3 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region DNA_pol3_delta2 PF13177.6 ADV23468.1 - 0.00023 21.0 1.6 0.0017 18.1 0.0 3.0 3 1 0 3 3 2 1 DNA polymerase III, delta subunit AAA_30 PF13604.6 ADV23468.1 - 0.00027 20.7 0.9 1.8 8.2 0.0 3.6 3 0 0 3 3 3 2 AAA domain TniB PF05621.11 ADV23468.1 - 0.00041 19.8 0.0 0.17 11.3 0.0 3.3 2 1 1 3 3 3 1 Bacterial TniB protein Roc PF08477.13 ADV23468.1 - 0.0006 20.0 0.0 0.23 11.7 0.0 2.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase SRP54 PF00448.22 ADV23468.1 - 0.00063 19.4 0.8 1.6 8.3 0.0 3.7 3 0 0 3 3 3 1 SRP54-type protein, GTPase domain AAA_28 PF13521.6 ADV23468.1 - 0.0011 19.3 0.8 9 6.5 0.0 3.7 3 0 0 3 3 3 0 AAA domain AAA_3 PF07726.11 ADV23468.1 - 0.0014 18.5 0.1 0.27 11.1 0.0 3.1 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 ADV23468.1 - 0.0017 17.7 0.1 0.37 10.1 0.0 2.8 2 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI NACHT PF05729.12 ADV23468.1 - 0.0028 17.6 0.1 3.1 7.7 0.0 2.6 2 0 0 2 2 2 1 NACHT domain RuvB_N PF05496.12 ADV23468.1 - 0.0046 16.7 3.4 0.55 10.0 0.0 3.6 3 1 0 3 3 2 1 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 ADV23468.1 - 0.0047 17.3 0.0 1 9.8 0.0 2.7 2 0 0 2 2 2 1 RNA helicase Torsin PF06309.11 ADV23468.1 - 0.0072 16.4 0.0 0.016 15.3 0.0 1.5 1 0 0 1 1 1 1 Torsin T2SSE PF00437.20 ADV23468.1 - 0.0076 15.3 1.0 0.028 13.5 1.0 2.0 1 1 0 1 1 1 1 Type II/IV secretion system protein AAA_33 PF13671.6 ADV23468.1 - 0.0087 16.2 0.8 3.2 7.9 0.0 2.9 3 0 0 3 3 2 1 AAA domain RsgA_GTPase PF03193.16 ADV23468.1 - 0.01 15.8 0.2 3.2 7.6 0.0 2.7 3 0 0 3 3 2 0 RsgA GTPase GTP_EFTU_D2 PF03144.25 ADV23468.1 - 0.036 14.4 0.7 0.14 12.6 0.2 2.2 2 1 0 2 2 1 0 Elongation factor Tu domain 2 ResIII PF04851.15 ADV23468.1 - 0.043 13.8 3.2 8.2 6.4 0.0 3.9 3 1 0 4 4 4 0 Type III restriction enzyme, res subunit TsaE PF02367.17 ADV23468.1 - 0.082 12.9 0.0 4.7 7.2 0.0 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_19 PF13245.6 ADV23468.1 - 0.09 13.1 0.1 5.4 7.3 0.0 2.9 2 1 0 2 2 2 0 AAA domain ABC_tran PF00005.27 ADV23468.1 - 0.091 13.3 4.3 2.3 8.8 0.0 3.5 3 1 0 3 3 3 0 ABC transporter Fez1 PF06818.15 ADV23468.1 - 0.13 12.7 14.0 0.25 11.8 14.0 1.4 1 0 0 1 1 1 0 Fez1 DUF1542 PF07564.11 ADV23468.1 - 0.15 12.2 3.8 0.36 11.0 3.8 1.6 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1542) NTPase_1 PF03266.15 ADV23468.1 - 0.16 11.9 2.3 47 3.8 0.0 3.9 4 0 0 4 4 3 0 NTPase AAA_23 PF13476.6 ADV23468.1 - 0.31 11.5 21.4 45 4.5 0.0 3.5 3 1 0 3 3 3 0 AAA domain LMBR1 PF04791.16 ADV23468.1 - 0.71 8.7 1.2 0.99 8.2 1.2 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein AAA_17 PF13207.6 ADV23468.1 - 1 9.8 4.9 14 6.1 0.0 3.4 3 1 0 3 3 2 0 AAA domain LUC7 PF03194.15 ADV23468.1 - 7.6 6.1 9.3 12 5.5 9.3 1.3 1 0 0 1 1 1 0 LUC7 N_terminus RNB PF00773.19 ADV23471.1 - 1.6e-99 333.4 0.0 1.6e-99 333.4 0.0 2.0 2 0 0 2 2 2 1 RNB domain OB_Dis3 PF17849.1 ADV23471.1 - 5.4e-26 90.4 0.0 1.1e-25 89.4 0.0 1.6 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) Dis3l2_C_term PF17877.1 ADV23471.1 - 1e-20 73.9 0.0 4e-20 71.9 0.0 2.1 1 0 0 1 1 1 1 DIS3-like exonuclease 2 C terminal CSD2 PF17876.1 ADV23471.1 - 3.1e-05 24.0 0.0 0.0093 16.1 0.0 2.8 2 0 0 2 2 2 1 Cold shock domain Rrp44_CSD1 PF17216.3 ADV23471.1 - 0.0057 16.4 0.0 0.012 15.4 0.0 1.5 1 0 0 1 1 1 1 Rrp44-like cold shock domain Rrp44_S1 PF17215.3 ADV23471.1 - 0.12 12.3 0.5 0.41 10.6 0.0 2.1 2 0 0 2 2 2 0 S1 domain Translin PF01997.16 ADV23472.1 - 1.4e-35 123.1 0.0 1.7e-35 122.9 0.0 1.0 1 0 0 1 1 1 1 Translin family Lipoprotein_7 PF01540.16 ADV23472.1 - 0.052 12.8 0.0 0.077 12.3 0.0 1.1 1 0 0 1 1 1 0 Adhesin lipoprotein Abi_2 PF07751.11 ADV23472.1 - 0.17 12.2 0.0 0.32 11.2 0.0 1.4 1 1 0 1 1 1 0 Abi-like protein MCM PF00493.23 ADV23473.1 - 1.5e-100 334.9 0.1 2.2e-100 334.4 0.1 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 ADV23473.1 - 2e-38 131.1 0.0 3.8e-38 130.2 0.0 1.4 1 0 0 1 1 1 1 MCM OB domain MCM2_N PF12619.8 ADV23473.1 - 2.5e-35 122.0 27.9 4.7e-35 121.1 26.1 2.2 2 0 0 2 2 2 1 Mini-chromosome maintenance protein 2 MCM_lid PF17855.1 ADV23473.1 - 1e-25 90.0 0.9 4.8e-25 87.8 0.3 2.4 2 0 0 2 2 2 1 MCM AAA-lid domain MCM_N PF14551.6 ADV23473.1 - 2.8e-13 50.3 0.0 1e-12 48.6 0.0 2.0 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 ADV23473.1 - 4.3e-07 29.5 0.0 1.2e-05 24.8 0.0 2.4 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 ADV23473.1 - 4.8e-06 26.6 0.0 1e-05 25.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 ADV23473.1 - 0.00012 21.9 0.1 0.0058 16.5 0.0 2.7 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) Yippee-Mis18 PF03226.14 ADV23473.1 - 0.009 16.2 0.1 0.019 15.2 0.1 1.5 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Sigma54_activat PF00158.26 ADV23473.1 - 0.016 14.9 0.1 0.097 12.4 0.1 2.0 1 1 0 1 1 1 0 Sigma-54 interaction domain SelR PF01641.18 ADV23473.1 - 0.033 14.2 0.1 8.1 6.6 0.1 2.5 2 0 0 2 2 2 0 SelR domain AAA_lid_2 PF17863.1 ADV23473.1 - 0.062 13.2 0.1 0.27 11.1 0.1 2.1 1 0 0 1 1 1 0 AAA lid domain Ytp1 PF10355.9 ADV23474.1 - 1.6e-103 345.7 13.6 2.6e-103 345.0 13.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (Ytp1) DUF2427 PF10348.9 ADV23474.1 - 4.7e-20 71.3 0.7 4.7e-20 71.3 0.7 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF2427) LAT PF15234.6 ADV23474.1 - 0.12 12.1 2.4 0.15 11.7 1.4 1.7 2 0 0 2 2 2 0 Linker for activation of T-cells MFMR_assoc PF16596.5 ADV23474.1 - 2.3 8.7 7.8 0.39 11.2 1.0 2.2 2 0 0 2 2 2 0 Disordered region downstream of MFMR Rep_fac_C PF08542.11 ADV23475.1 - 1.3e-26 92.8 0.0 2.9e-26 91.7 0.0 1.6 1 0 0 1 1 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.6 ADV23475.1 - 7.2e-14 51.9 0.1 2e-10 40.7 0.2 2.2 1 1 1 2 2 2 2 DNA polymerase III, delta subunit AAA PF00004.29 ADV23475.1 - 1.8e-11 44.6 0.0 3e-11 43.9 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 ADV23475.1 - 1.7e-06 28.1 0.0 3.4e-06 27.1 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ADV23475.1 - 4.2e-06 27.2 0.0 0.00036 21.0 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 ADV23475.1 - 1.7e-05 25.1 0.1 0.031 14.6 0.0 2.4 1 1 1 2 2 2 2 AAA domain AAA_3 PF07726.11 ADV23475.1 - 2.7e-05 24.0 0.0 4.4e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Viral_helicase1 PF01443.18 ADV23475.1 - 0.00012 21.9 0.0 0.00019 21.2 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase RuvB_N PF05496.12 ADV23475.1 - 0.00014 21.6 0.0 0.00036 20.3 0.0 1.7 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 ADV23475.1 - 0.0012 18.3 0.0 0.015 14.7 0.0 2.1 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI Rad17 PF03215.15 ADV23475.1 - 0.0027 17.6 0.0 0.0055 16.6 0.0 1.5 1 0 0 1 1 1 1 Rad17 P-loop domain NTPase_1 PF03266.15 ADV23475.1 - 0.0036 17.2 0.2 0.016 15.1 0.1 2.0 1 1 1 2 2 2 1 NTPase DNA_pol3_delta PF06144.13 ADV23475.1 - 0.0068 16.2 0.0 0.0099 15.7 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase III, delta subunit MeaB PF03308.16 ADV23475.1 - 0.0085 15.1 0.0 0.019 14.0 0.0 1.6 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_assoc_2 PF16193.5 ADV23475.1 - 0.019 15.3 0.0 0.056 13.8 0.0 1.8 2 0 0 2 2 1 0 AAA C-terminal domain AAA_24 PF13479.6 ADV23475.1 - 0.03 14.1 0.0 0.073 12.8 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_11 PF13086.6 ADV23475.1 - 0.038 13.8 0.0 0.057 13.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 ADV23475.1 - 0.038 14.3 0.2 0.12 12.7 0.2 1.9 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 ADV23475.1 - 0.039 13.9 0.0 0.13 12.2 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) TniB PF05621.11 ADV23475.1 - 0.064 12.6 0.0 3.9 6.8 0.0 2.4 2 0 0 2 2 2 0 Bacterial TniB protein KTI12 PF08433.10 ADV23475.1 - 0.068 12.6 0.0 0.098 12.1 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_30 PF13604.6 ADV23475.1 - 0.069 12.9 0.1 0.16 11.6 0.1 1.6 1 1 0 1 1 1 0 AAA domain PrpR_N PF06506.11 ADV23475.1 - 0.074 12.6 0.0 0.16 11.5 0.0 1.5 1 0 0 1 1 1 0 Propionate catabolism activator RNA_helicase PF00910.22 ADV23475.1 - 0.077 13.4 0.1 0.23 11.8 0.1 1.9 1 1 0 1 1 1 0 RNA helicase SRP54 PF00448.22 ADV23475.1 - 0.085 12.5 0.0 0.17 11.5 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_23 PF13476.6 ADV23475.1 - 0.094 13.2 0.0 0.13 12.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.18 ADV23475.1 - 0.11 11.8 0.1 0.33 10.3 0.0 1.7 2 0 0 2 2 2 0 FtsK/SpoIIIE family ParA PF10609.9 ADV23475.1 - 0.13 11.7 0.0 1.2 8.5 0.0 2.2 2 1 0 2 2 2 0 NUBPL iron-transfer P-loop NTPase RMI1_N PF08585.12 ADV23476.1 - 1.1e-38 133.2 0.0 1.1e-38 133.2 0.0 2.7 2 1 0 2 2 2 1 RecQ mediated genome instability protein RGI1 PF10843.8 ADV23476.1 - 0.16 11.6 5.3 4 7.1 0.2 2.4 1 1 1 2 2 2 0 Respiratory growth induced protein 1 KfrA_N PF11740.8 ADV23476.1 - 0.27 11.9 0.0 0.27 11.9 0.0 2.7 3 0 0 3 3 3 0 Plasmid replication region DNA-binding N-term V_ATPase_I PF01496.19 ADV23476.1 - 3.2 5.5 5.2 4.3 5.1 5.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family LapA_dom PF06305.11 ADV23477.1 - 0.057 13.2 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain DUF2207 PF09972.9 ADV23477.1 - 0.066 12.0 0.0 0.098 11.4 0.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) ORC6 PF05460.13 ADV23477.1 - 0.23 10.7 12.6 0.36 10.0 12.6 1.3 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Utp14 PF04615.13 ADV23477.1 - 0.39 9.2 5.7 0.49 8.9 5.7 1.1 1 0 0 1 1 1 0 Utp14 protein PPP4R2 PF09184.11 ADV23477.1 - 6.9 6.2 13.2 10 5.6 13.2 1.3 1 0 0 1 1 1 0 PPP4R2 Chitin_synth_1 PF01644.17 ADV23478.1 - 8e-67 224.3 0.1 1.2e-66 223.7 0.1 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_2 PF03142.15 ADV23478.1 - 2.4e-27 95.8 0.1 6e-21 74.6 0.0 2.4 2 0 0 2 2 2 2 Chitin synthase Chitin_synth_1N PF08407.11 ADV23478.1 - 5.8e-25 87.0 0.0 1.7e-24 85.5 0.0 1.8 2 0 0 2 2 2 1 Chitin synthase N-terminal Glyco_trans_2_3 PF13632.6 ADV23478.1 - 5.7e-12 46.0 0.2 5.7e-12 46.0 0.2 2.7 3 0 0 3 3 3 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 ADV23478.1 - 2.9e-05 24.1 0.0 9.6e-05 22.4 0.0 1.9 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 ADV23478.1 - 0.0019 18.0 0.0 0.28 11.0 0.0 2.4 2 0 0 2 2 2 2 Glycosyl transferase family 2 Vps52 PF04129.12 ADV23479.1 - 1.2e-57 195.9 0.0 1e-42 146.6 0.0 2.0 2 0 0 2 2 2 2 Vps52 / Sac2 family Sec3_C PF09763.9 ADV23479.1 - 7.2e-05 21.4 0.1 0.00012 20.7 0.1 1.4 1 0 0 1 1 1 1 Exocyst complex component Sec3 TolA_bind_tri PF16331.5 ADV23479.1 - 0.00033 20.7 0.5 0.001 19.1 0.5 1.8 1 0 0 1 1 1 1 TolA binding protein trimerisation ATG16 PF08614.11 ADV23479.1 - 0.0011 19.2 0.6 0.012 15.8 0.1 2.4 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) NPV_P10 PF05531.12 ADV23479.1 - 0.0071 16.8 0.9 1.1 9.7 0.3 2.8 2 0 0 2 2 2 1 Nucleopolyhedrovirus P10 protein DUF2730 PF10805.8 ADV23479.1 - 0.0096 16.0 0.2 0.063 13.4 0.1 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF2730) Hormone_1 PF00103.20 ADV23479.1 - 0.029 14.1 0.2 0.061 13.1 0.2 1.5 1 0 0 1 1 1 0 Somatotropin hormone family IFT57 PF10498.9 ADV23479.1 - 0.034 13.1 0.4 0.06 12.3 0.4 1.3 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 MscS_porin PF12795.7 ADV23479.1 - 0.13 11.8 7.6 0.026 14.1 3.5 1.9 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain DUF4795 PF16043.5 ADV23479.1 - 0.13 11.8 1.7 0.83 9.2 0.4 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4795) DegS PF05384.11 ADV23479.1 - 0.68 9.4 7.9 0.068 12.7 1.6 2.4 3 0 0 3 3 3 0 Sensor protein DegS APG6_N PF17675.1 ADV23479.1 - 8.3 6.9 8.3 2.2 8.8 3.5 2.4 2 1 0 2 2 2 0 Apg6 coiled-coil region GDP_Man_Dehyd PF16363.5 ADV23480.1 - 1.9e-58 198.5 0.0 2.4e-58 198.1 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 ADV23480.1 - 5.1e-48 163.7 0.0 6.9e-48 163.2 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family UXS1_N PF11803.8 ADV23480.1 - 4.5e-14 52.6 0.0 9.1e-14 51.6 0.0 1.5 1 0 0 1 1 1 1 UDP-glucuronate decarboxylase N-terminal 3Beta_HSD PF01073.19 ADV23480.1 - 1.7e-11 43.7 0.0 2.6e-11 43.1 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 ADV23480.1 - 1.3e-07 31.1 0.1 0.0011 18.3 0.0 2.3 2 0 0 2 2 2 2 Male sterility protein RmlD_sub_bind PF04321.17 ADV23480.1 - 2.7e-07 30.0 0.0 3.6e-07 29.6 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 ADV23480.1 - 0.00019 20.7 0.0 0.048 12.8 0.1 3.0 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein VPS9 PF02204.18 ADV23481.1 - 9.6e-30 102.9 0.0 1.6e-29 102.1 0.0 1.4 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain DUF5601 PF18151.1 ADV23481.1 - 2e-15 56.9 0.2 8.9e-15 54.8 0.5 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF5601) CUE PF02845.16 ADV23481.1 - 6.9e-10 38.4 0.3 6.9e-10 38.4 0.3 2.3 3 0 0 3 3 3 1 CUE domain DMA PF03474.14 ADV23481.1 - 0.0026 17.3 0.0 0.0049 16.4 0.0 1.5 1 0 0 1 1 1 1 DMRTA motif SAM_2 PF07647.17 ADV23482.1 - 1.3e-07 31.6 0.0 2.2e-07 30.9 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ADV23482.1 - 2.4e-05 24.7 0.1 4.1e-05 23.9 0.1 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_Ste50p PF09235.10 ADV23482.1 - 0.00037 20.7 0.2 0.00064 19.9 0.2 1.4 1 0 0 1 1 1 1 Ste50p, sterile alpha motif SAM_3 PF18016.1 ADV23482.1 - 0.0077 16.0 0.0 0.014 15.2 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PH PF00169.29 ADV23483.1 - 3.1e-12 46.9 0.0 5.5e-12 46.1 0.0 1.4 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 ADV23483.1 - 0.048 14.0 0.1 0.14 12.4 0.0 1.7 2 0 0 2 2 2 0 Pleckstrin homology domain Ras PF00071.22 ADV23485.1 - 3.1e-55 186.2 0.0 3.6e-55 186.0 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ADV23485.1 - 7.4e-21 74.6 0.0 1e-20 74.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ADV23485.1 - 4.2e-07 29.6 0.0 7.2e-07 28.8 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ADV23485.1 - 0.00074 19.1 0.1 0.0018 17.8 0.0 1.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 ADV23485.1 - 0.0013 18.2 0.0 0.0018 17.8 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit NB-ARC PF00931.22 ADV23485.1 - 0.019 14.1 0.0 0.27 10.4 0.0 2.0 1 1 0 2 2 2 0 NB-ARC domain Gtr1_RagA PF04670.12 ADV23485.1 - 0.083 12.2 0.0 0.089 12.1 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region YTH PF04146.15 ADV23486.1 - 1.7e-37 128.9 0.1 4.1e-37 127.7 0.1 1.7 1 0 0 1 1 1 1 YT521-B-like domain Rrn6 PF10214.9 ADV23487.1 - 0.011 14.2 2.8 0.013 14.1 2.8 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Nop53 PF07767.11 ADV23487.1 - 0.29 10.5 9.5 0.36 10.2 9.5 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) NARP1 PF12569.8 ADV23487.1 - 0.74 8.6 9.9 0.97 8.3 9.9 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 HMG_CoA_synt_N PF01154.17 ADV23488.1 - 9e-84 279.7 0.1 2.5e-83 278.2 0.1 1.8 2 0 0 2 2 2 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal HMG_CoA_synt_C PF08540.10 ADV23488.1 - 5.3e-82 275.6 0.0 3e-60 204.2 0.0 2.2 1 1 0 2 2 2 2 Hydroxymethylglutaryl-coenzyme A synthase C terminal ACP_syn_III PF08545.10 ADV23488.1 - 0.026 14.4 0.6 0.12 12.2 0.0 2.4 2 1 1 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III ACP_syn_III_C PF08541.10 ADV23488.1 - 0.12 12.5 0.1 0.35 11.1 0.1 1.8 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal cwf21 PF08312.12 ADV23489.1 - 7.8e-16 58.0 14.3 7.8e-16 58.0 14.3 3.0 2 1 0 2 2 2 1 cwf21 domain LMBR1 PF04791.16 ADV23489.1 - 1.7 7.4 6.8 2.1 7.1 6.8 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein He_PIG PF05345.12 ADV23490.1 - 4.3e-22 78.0 28.5 1.2e-08 35.0 2.3 6.7 5 1 1 6 6 6 5 Putative Ig domain Mid2 PF04478.12 ADV23490.1 - 0.0021 17.9 0.1 0.0057 16.5 0.1 1.7 1 0 0 1 1 1 1 Mid2 like cell wall stress sensor Sarcoglycan_2 PF05510.13 ADV23490.1 - 0.01 14.6 0.1 3.2 6.4 0.0 3.1 3 0 0 3 3 3 0 Sarcoglycan alpha/epsilon EphA2_TM PF14575.6 ADV23490.1 - 0.17 12.8 0.0 0.34 11.8 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain SKG6 PF08693.10 ADV23490.1 - 0.22 11.0 0.9 0.56 9.7 0.9 1.7 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Adeno_E3_CR2 PF02439.15 ADV23490.1 - 0.26 11.1 0.1 0.51 10.1 0.1 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Mo25 PF08569.11 ADV23491.1 - 4.7e-130 433.7 4.2 5.2e-130 433.6 4.2 1.0 1 0 0 1 1 1 1 Mo25-like XPC-binding PF09280.11 ADV23491.1 - 0.046 13.5 4.0 1.2 8.9 0.0 3.1 3 0 0 3 3 3 0 XPC-binding domain zf-Tim10_DDP PF02953.15 ADV23493.1 - 4.4e-22 77.5 4.2 5.8e-22 77.1 4.2 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger PMEI PF04043.15 ADV23493.1 - 0.0029 18.0 0.8 0.0034 17.8 0.8 1.1 1 0 0 1 1 1 1 Plant invertase/pectin methylesterase inhibitor DUF4372 PF14294.6 ADV23493.1 - 0.022 14.9 0.1 0.034 14.3 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4372) BolA PF01722.18 ADV23494.1 - 3.3e-16 59.3 0.2 5e-16 58.7 0.2 1.3 1 1 0 1 1 1 1 BolA-like protein zf-C2H2 PF00096.26 ADV23495.1 - 0.045 14.2 4.2 0.087 13.3 4.2 1.5 1 0 0 1 1 1 0 Zinc finger, C2H2 type DUF4674 PF15719.5 ADV23495.1 - 0.078 13.0 0.3 0.21 11.6 0.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4674) UPF0172 PF03665.13 ADV23496.1 - 8.5e-33 114.0 0.0 1.6e-32 113.1 0.0 1.4 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0172) THUMP PF02926.17 ADV23497.1 - 9.4e-15 55.0 1.2 3.4e-14 53.2 0.0 2.3 2 1 1 3 3 3 1 THUMP domain MMPL PF03176.15 ADV23497.1 - 0.11 11.4 0.0 0.21 10.5 0.0 1.4 1 0 0 1 1 1 0 MMPL family Cyclin_N PF00134.23 ADV23498.1 - 4.6e-13 49.0 0.2 7.8e-13 48.3 0.2 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 ADV23498.1 - 2.8e-09 37.6 0.1 5.9e-09 36.5 0.1 1.5 1 0 0 1 1 1 1 Cyclin Mito_carr PF00153.27 ADV23499.1 - 7.3e-37 125.2 0.1 1.2e-18 66.8 0.0 2.2 2 0 0 2 2 2 2 Mitochondrial carrier protein TauD PF02668.16 ADV23500.1 - 2.6e-54 184.8 0.0 3.3e-54 184.5 0.0 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family AAA PF00004.29 ADV23501.1 - 4.3e-87 289.3 0.0 1.8e-42 144.9 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ADV23501.1 - 1.9e-23 82.0 0.1 8.2e-12 44.7 0.1 2.7 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 ADV23501.1 - 9.3e-13 48.9 0.2 5.7e-05 23.6 0.1 4.2 2 2 1 4 4 4 2 AAA ATPase domain RuvB_N PF05496.12 ADV23501.1 - 2.7e-12 46.7 0.0 0.00016 21.5 0.0 3.4 2 2 1 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 ADV23501.1 - 2.5e-11 43.8 0.1 0.00012 22.1 0.0 4.1 3 2 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 ADV23501.1 - 3.8e-09 36.9 0.0 0.0026 17.9 0.0 3.1 3 1 0 3 3 3 2 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 ADV23501.1 - 4.3e-09 36.7 0.0 6.4e-05 23.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 ADV23501.1 - 3.1e-08 34.0 0.7 0.0028 17.9 0.0 4.2 2 2 0 2 2 2 2 AAA domain TIP49 PF06068.13 ADV23501.1 - 1.3e-07 31.2 0.0 0.0038 16.5 0.0 2.3 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_28 PF13521.6 ADV23501.1 - 3.7e-06 27.3 0.0 0.054 13.7 0.0 3.3 3 0 0 3 3 3 2 AAA domain Rad17 PF03215.15 ADV23501.1 - 6.6e-06 26.2 0.0 0.0015 18.5 0.0 2.6 2 0 0 2 2 2 1 Rad17 P-loop domain TsaE PF02367.17 ADV23501.1 - 3.3e-05 23.9 0.0 0.066 13.2 0.0 2.5 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE IstB_IS21 PF01695.17 ADV23501.1 - 3.3e-05 23.7 0.0 0.054 13.2 0.0 2.4 2 0 0 2 2 2 2 IstB-like ATP binding protein Mg_chelatase PF01078.21 ADV23501.1 - 4.8e-05 22.8 0.6 0.31 10.4 0.1 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 ADV23501.1 - 6.9e-05 23.4 0.0 0.017 15.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 ADV23501.1 - 0.00012 22.2 0.0 0.38 10.8 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.6 ADV23501.1 - 0.00022 20.9 0.7 1.6 8.3 0.0 4.1 5 0 0 5 5 5 1 AAA domain RNA_helicase PF00910.22 ADV23501.1 - 0.00027 21.3 0.0 1 9.8 0.0 2.5 2 0 0 2 2 2 2 RNA helicase AAA_11 PF13086.6 ADV23501.1 - 0.0006 19.7 0.4 0.22 11.3 0.0 2.8 3 0 0 3 3 3 1 AAA domain NACHT PF05729.12 ADV23501.1 - 0.00084 19.3 0.3 0.11 12.4 0.0 3.1 3 0 0 3 3 3 1 NACHT domain AAA_3 PF07726.11 ADV23501.1 - 0.00088 19.1 0.0 2 8.3 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 ADV23501.1 - 0.0011 18.4 0.0 0.23 10.7 0.0 2.3 2 0 0 2 2 2 1 Zeta toxin AAA_7 PF12775.7 ADV23501.1 - 0.0018 17.8 0.0 1.7 8.1 0.0 2.3 2 0 0 2 2 2 2 P-loop containing dynein motor region Molydop_binding PF01568.21 ADV23501.1 - 0.0025 17.8 0.0 0.1 12.6 0.0 2.6 2 0 0 2 2 2 1 Molydopterin dinucleotide binding domain Sigma54_activ_2 PF14532.6 ADV23501.1 - 0.0053 16.9 0.0 0.62 10.2 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain Sigma54_activat PF00158.26 ADV23501.1 - 0.0091 15.7 0.0 3.4 7.3 0.0 3.6 2 2 0 2 2 2 1 Sigma-54 interaction domain IPT PF01745.16 ADV23501.1 - 0.019 14.4 0.4 1 8.7 0.1 2.3 2 0 0 2 2 2 0 Isopentenyl transferase AAA_24 PF13479.6 ADV23501.1 - 0.032 13.9 0.0 2.9 7.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_6 PF12774.7 ADV23501.1 - 0.036 13.0 0.2 0.76 8.7 0.0 2.1 2 0 0 2 2 2 0 Hydrolytic ATP binding site of dynein motor region ATPase PF06745.13 ADV23501.1 - 0.065 12.6 0.0 6.2 6.1 0.0 2.6 3 0 0 3 3 2 0 KaiC AAA_30 PF13604.6 ADV23501.1 - 0.12 12.1 0.2 1.5 8.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 ADV23501.1 - 0.13 12.8 0.0 6 7.4 0.0 2.6 2 0 0 2 2 2 0 ABC transporter Viral_helicase1 PF01443.18 ADV23501.1 - 0.14 11.8 0.0 2.9 7.6 0.0 2.2 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase DUF815 PF05673.13 ADV23501.1 - 0.2 10.8 0.0 9.8 5.3 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Hydin_ADK PF17213.3 ADV23501.1 - 7 6.9 5.7 2.2 8.5 0.1 2.6 3 0 0 3 3 3 0 Hydin Adenylate kinase-like domain Helicase_C PF00271.31 ADV23502.1 - 2.6e-08 34.2 0.0 5.4e-08 33.2 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 ADV23502.1 - 2.1e-05 23.4 0.0 0.0062 15.3 0.0 2.2 2 0 0 2 2 2 2 SNF2 family N-terminal domain Nfu_N PF08712.11 ADV23503.1 - 8.3e-29 99.5 0.0 1.7e-28 98.5 0.0 1.6 1 0 0 1 1 1 1 Scaffold protein Nfu/NifU N terminal NifU PF01106.17 ADV23503.1 - 4.6e-27 94.0 0.1 7.4e-27 93.3 0.1 1.3 1 0 0 1 1 1 1 NifU-like domain TOH_N PF12549.8 ADV23503.1 - 0.054 13.4 0.3 0.17 11.7 0.3 1.9 1 0 0 1 1 1 0 Tyrosine hydroxylase N terminal NUDIX PF00293.28 ADV23504.1 - 1.7e-15 57.3 0.0 2.5e-15 56.7 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain NUDIX-like PF09296.11 ADV23504.1 - 4.2e-14 53.1 0.0 9.4e-14 51.9 0.0 1.6 1 0 0 1 1 1 1 NADH pyrophosphatase-like rudimentary NUDIX domain zf-NADH-PPase PF09297.11 ADV23504.1 - 5.7e-05 22.7 2.6 0.00012 21.7 0.9 2.2 2 0 0 2 2 2 1 NADH pyrophosphatase zinc ribbon domain zinc_ribbon_2 PF13240.6 ADV23504.1 - 0.16 11.7 1.1 0.36 10.6 1.1 1.6 1 0 0 1 1 1 0 zinc-ribbon domain Nudix_N_2 PF14803.6 ADV23504.1 - 0.17 11.8 0.2 0.4 10.7 0.2 1.6 1 0 0 1 1 1 0 Nudix N-terminal Zip PF02535.22 ADV23506.1 - 8.2e-42 143.6 18.8 8.2e-42 143.6 18.8 2.7 1 1 1 2 2 2 1 ZIP Zinc transporter DUF2946 PF11162.8 ADV23506.1 - 0.061 14.0 0.4 0.15 12.8 0.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2946) GATA PF00320.27 ADV23507.1 - 5.2e-11 42.0 2.8 1.5e-10 40.5 2.8 1.8 1 0 0 1 1 1 1 GATA zinc finger TFIIA PF03153.13 ADV23507.1 - 0.028 14.4 9.4 0.04 13.9 9.4 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Phage_fiber_2 PF03406.13 ADV23508.1 - 0.41 10.2 2.8 0.98 9.0 2.8 1.6 1 0 0 1 1 1 0 Phage tail fibre repeat PHD PF00628.29 ADV23509.1 - 1.2e-10 41.1 4.8 2.9e-10 39.9 4.8 1.7 1 0 0 1 1 1 1 PHD-finger zf-CpG_bind_C PF12269.8 ADV23509.1 - 4.3e-05 23.4 4.1 0.00036 20.4 0.2 2.7 1 1 1 2 2 2 2 CpG binding protein zinc finger C terminal domain PHD_2 PF13831.6 ADV23509.1 - 0.023 14.2 2.5 0.047 13.2 2.5 1.6 1 0 0 1 1 1 0 PHD-finger DUF3429 PF11911.8 ADV23510.1 - 6.2e-39 133.6 14.4 8.1e-39 133.2 14.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3429) adh_short PF00106.25 ADV23511.1 - 6.4e-37 126.9 0.0 8.3e-37 126.5 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ADV23511.1 - 7.6e-28 97.7 0.0 8.5e-28 97.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ADV23511.1 - 2.5e-13 50.3 0.0 3.3e-13 49.9 0.0 1.2 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 ADV23511.1 - 8.7e-05 22.0 0.0 0.00011 21.7 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) NAD_binding_10 PF13460.6 ADV23511.1 - 0.007 16.3 0.3 0.019 14.9 0.3 1.8 1 1 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 ADV23511.1 - 0.071 12.3 0.2 1.6 7.9 0.2 2.8 1 1 0 1 1 1 0 Male sterility protein Polysacc_lyase PF14099.6 ADV23512.1 - 0.0043 16.9 0.3 0.01 15.7 0.3 1.6 1 1 0 1 1 1 1 Polysaccharide lyase DUF1080 PF06439.11 ADV23512.1 - 0.011 15.8 0.0 0.022 14.9 0.0 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1080) RNase_T PF00929.24 ADV23513.1 - 7.8e-07 29.8 0.0 1e-06 29.4 0.0 1.2 1 0 0 1 1 1 1 Exonuclease UK PF02512.14 ADV23513.1 - 0.027 15.0 0.0 0.048 14.2 0.0 1.4 1 0 0 1 1 1 0 Virulence determinant DEAD PF00270.29 ADV23517.1 - 2.2e-46 157.8 0.0 5.9e-46 156.4 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ADV23517.1 - 1.2e-25 90.0 0.0 4.9e-25 88.0 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 ADV23517.1 - 0.068 12.4 0.0 0.068 12.4 0.0 2.3 2 0 0 2 2 2 0 ERCC3/RAD25/XPB C-terminal helicase CMS1 PF14617.6 ADV23517.1 - 0.94 8.8 0.0 0.94 8.8 0.0 2.4 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit Hid1 PF12722.7 ADV23517.1 - 9.8 4.2 10.2 13 3.7 10.2 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Peptidase_M20 PF01546.28 ADV23518.1 - 1.1e-29 103.6 0.0 2.9e-29 102.2 0.0 1.7 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 ADV23518.1 - 1e-10 41.5 0.0 5.5e-10 39.1 0.0 2.2 2 1 0 2 2 2 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 ADV23518.1 - 0.021 14.5 0.0 0.038 13.7 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M28 C2 PF00168.30 ADV23519.1 - 2.9e-14 53.2 0.0 3e-11 43.5 0.0 2.4 2 0 0 2 2 2 2 C2 domain Spt20 PF12090.8 ADV23520.1 - 7.7 6.0 20.0 0.27 10.8 7.0 2.6 2 0 0 2 2 2 0 Spt20 family Mito_carr PF00153.27 ADV23521.1 - 1.3e-57 191.7 6.6 2.9e-20 72.0 0.3 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Amidohydro_2 PF04909.14 ADV23522.1 - 2.2e-25 90.0 1.1 2.7e-25 89.7 1.1 1.1 1 0 0 1 1 1 1 Amidohydrolase Glyco_hydro_97 PF10566.9 ADV23522.1 - 0.18 11.1 0.6 0.32 10.2 0.2 1.5 2 0 0 2 2 2 0 Glycoside hydrolase 97 Zn_clus PF00172.18 ADV23523.1 - 9e-06 25.7 9.3 2e-05 24.6 9.3 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sugar_tr PF00083.24 ADV23524.1 - 8.3e-104 348.0 23.0 9.6e-104 347.7 23.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ADV23524.1 - 7.2e-25 87.7 44.0 7.8e-18 64.5 13.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2070 PF09843.9 ADV23524.1 - 3.8 5.7 20.2 0.016 13.5 1.9 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2070) Ribosomal_L7Ae PF01248.26 ADV23525.1 - 8.3e-26 89.6 0.1 1.1e-25 89.2 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PELOTA_1 PF15608.6 ADV23525.1 - 0.0028 17.5 0.0 0.0039 17.0 0.0 1.3 1 0 0 1 1 1 1 PELOTA RNA binding domain Gpi16 PF04113.14 ADV23527.1 - 1e-120 403.8 0.0 6.2e-119 398.0 0.0 2.0 1 1 0 1 1 1 1 Gpi16 subunit, GPI transamidase component DUF2477 PF10631.9 ADV23528.1 - 2.4 8.8 8.3 0.61 10.7 3.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2477) Mito_carr PF00153.27 ADV23529.1 - 5.1e-41 138.5 0.1 1.3e-14 53.9 0.0 3.4 3 1 0 3 3 3 3 Mitochondrial carrier protein Atg14 PF10186.9 ADV23530.1 - 0.084 11.9 40.2 0.042 12.9 0.3 4.3 1 1 2 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 tRNA_edit PF04073.15 ADV23530.1 - 0.19 11.8 0.7 17 5.5 0.1 2.6 2 0 0 2 2 2 0 Aminoacyl-tRNA editing domain XPA_C PF05181.12 ADV23531.1 - 2.4e-24 85.0 1.6 4.7e-24 84.1 1.6 1.5 1 0 0 1 1 1 1 XPA protein C-terminus XPA_N PF01286.18 ADV23531.1 - 0.0014 18.6 2.3 0.0014 18.6 2.3 2.3 2 0 0 2 2 2 1 XPA protein N-terminal ADD_DNMT3 PF17980.1 ADV23531.1 - 0.079 13.0 3.4 0.41 10.7 0.4 2.5 2 0 0 2 2 2 0 Cysteine rich ADD domain in DNMT3 DZR PF12773.7 ADV23531.1 - 0.15 12.1 2.6 0.66 10.1 0.8 2.3 2 0 0 2 2 2 0 Double zinc ribbon MHC_I PF00129.18 ADV23531.1 - 1.6 8.3 6.9 2.9 7.4 0.5 2.3 1 1 1 2 2 2 0 Class I Histocompatibility antigen, domains alpha 1 and 2 ABC_tran PF00005.27 ADV23532.1 - 8e-43 146.2 0.0 2.1e-24 86.6 0.0 3.0 2 1 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 ADV23532.1 - 3.8e-42 144.8 31.0 2.8e-26 92.8 15.0 3.7 3 1 1 4 4 4 3 ABC transporter transmembrane region SMC_N PF02463.19 ADV23532.1 - 4.5e-11 42.6 7.5 1.5e-07 31.1 1.9 3.9 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 ADV23532.1 - 0.00052 19.9 0.3 3.9 7.2 0.0 4.2 4 0 0 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system T2SSE PF00437.20 ADV23532.1 - 0.00053 19.1 0.0 0.19 10.8 0.0 2.6 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_22 PF13401.6 ADV23532.1 - 0.00056 20.2 7.1 0.62 10.3 0.0 3.9 4 0 0 4 4 3 2 AAA domain AAA_33 PF13671.6 ADV23532.1 - 0.0013 18.9 0.0 0.82 9.8 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.6 ADV23532.1 - 0.0015 19.1 0.5 1.7 9.1 0.1 2.4 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.6 ADV23532.1 - 0.0017 18.0 0.0 0.67 9.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 ADV23532.1 - 0.0017 18.1 0.0 0.33 10.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain DEAD PF00270.29 ADV23532.1 - 0.0036 17.1 0.3 0.19 11.5 0.1 2.6 2 1 0 2 2 2 1 DEAD/DEAH box helicase AAA_29 PF13555.6 ADV23532.1 - 0.0059 16.3 4.3 1 9.2 0.2 2.9 3 0 0 3 3 2 2 P-loop containing region of AAA domain AAA_18 PF13238.6 ADV23532.1 - 0.03 14.9 0.4 15 6.1 0.0 2.8 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 ADV23532.1 - 0.034 13.7 1.9 0.17 11.5 0.5 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_16 PF13191.6 ADV23532.1 - 0.037 14.4 2.2 2.7 8.3 0.1 3.4 3 0 0 3 3 3 0 AAA ATPase domain Dynamin_N PF00350.23 ADV23532.1 - 0.053 13.6 0.6 6.1 6.9 0.1 2.5 2 0 0 2 2 2 0 Dynamin family RsgA_GTPase PF03193.16 ADV23532.1 - 0.053 13.4 0.1 2.4 8.0 0.0 2.5 2 0 0 2 2 2 0 RsgA GTPase MeaB PF03308.16 ADV23532.1 - 0.071 12.1 0.0 0.14 11.1 0.0 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB PRK PF00485.18 ADV23532.1 - 0.08 12.7 0.0 0.28 10.9 0.0 1.9 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family DUF87 PF01935.17 ADV23532.1 - 0.13 12.3 0.7 0.4 10.8 0.1 2.0 2 0 0 2 2 2 0 Helicase HerA, central domain MMR_HSR1 PF01926.23 ADV23532.1 - 0.18 11.9 0.9 14 5.8 0.0 3.3 3 0 0 3 3 3 0 50S ribosome-binding GTPase Roc PF08477.13 ADV23532.1 - 0.23 11.7 0.7 11 6.3 0.0 3.3 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase AAA_15 PF13175.6 ADV23532.1 - 0.34 10.6 2.3 11 5.7 0.1 2.8 2 1 0 3 3 3 0 AAA ATPase domain IstB_IS21 PF01695.17 ADV23532.1 - 1.5 8.5 4.4 7.2 6.3 0.0 3.4 4 0 0 4 4 4 0 IstB-like ATP binding protein ATP_bind_1 PF03029.17 ADV23532.1 - 1.5 8.6 4.0 8.6 6.1 0.1 2.8 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein IF-2B PF01008.17 ADV23533.1 - 4.4e-62 209.8 0.0 5.5e-62 209.5 0.0 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family Prefoldin PF02996.17 ADV23534.1 - 1e-16 61.0 0.4 1.1e-16 60.8 0.4 1.1 1 0 0 1 1 1 1 Prefoldin subunit GnsAB_toxin PF08178.11 ADV23534.1 - 0.053 13.5 1.6 0.38 10.7 0.1 2.1 2 0 0 2 2 2 0 GnsA/GnsB toxin of bacterial toxin-antitoxin system Nnf1 PF03980.14 ADV23534.1 - 0.078 13.4 3.1 0.75 10.2 0.3 2.2 1 1 0 2 2 2 0 Nnf1 Prefoldin_2 PF01920.20 ADV23534.1 - 0.12 12.3 4.0 0.75 9.8 0.4 2.2 2 0 0 2 2 2 0 Prefoldin subunit DUF5407 PF17401.2 ADV23534.1 - 0.12 12.6 0.0 0.5 10.7 0.0 2.0 2 1 0 2 2 2 0 Family of unknown function (DUF5407) Ribosomal_S21 PF01165.20 ADV23535.1 - 2e-11 43.5 6.3 3.1e-11 42.8 6.3 1.3 1 0 0 1 1 1 1 Ribosomal protein S21 MAS20 PF02064.15 ADV23536.1 - 3.7e-38 130.5 0.4 5.7e-38 129.9 0.4 1.2 1 0 0 1 1 1 1 MAS20 protein import receptor PMC2NT PF08066.12 ADV23536.1 - 0.037 14.7 0.0 0.067 13.9 0.0 1.4 1 0 0 1 1 1 0 PMC2NT (NUC016) domain Erythro_esteras PF05139.14 ADV23536.1 - 0.13 12.0 1.6 0.095 12.5 0.3 1.4 2 0 0 2 2 2 0 Erythromycin esterase Sugar_tr PF00083.24 ADV23538.1 - 1.2e-109 367.2 18.0 1.2e-109 367.2 18.0 1.3 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_1 PF07690.16 ADV23538.1 - 1.6e-17 63.5 16.2 1.6e-17 63.5 16.2 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily Totivirus_coat PF05518.11 ADV23539.1 - 0.97 7.4 4.8 1 7.3 4.8 1.0 1 0 0 1 1 1 0 Totivirus coat protein Aminotran_1_2 PF00155.21 ADV23540.1 - 4.7e-34 118.2 0.0 8.1e-34 117.4 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II MFS_1 PF07690.16 ADV23541.1 - 1.8e-15 56.7 37.2 8.3e-10 38.1 11.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 ADV23541.1 - 2e-12 46.4 8.8 3.4e-12 45.6 8.8 1.3 1 0 0 1 1 1 1 MFS/sugar transport protein Glyco_hydro_114 PF03537.13 ADV23543.1 - 1.1e-74 250.6 0.5 1.6e-74 250.1 0.5 1.2 1 0 0 1 1 1 1 Glycoside-hydrolase family GH114 GCOM2 PF15328.6 ADV23543.1 - 0.54 10.6 1.4 0.84 10.0 1.4 1.2 1 0 0 1 1 1 0 Putative GRINL1B complex locus protein 2 RraA-like PF03737.15 ADV23544.1 - 1.3e-31 109.8 0.0 1.5e-31 109.6 0.0 1.1 1 0 0 1 1 1 1 Aldolase/RraA Phage_Arf PF17585.2 ADV23544.1 - 0.1 12.6 0.1 0.18 11.8 0.1 1.3 1 0 0 1 1 1 0 Accessory recombination function protein Aconitase PF00330.20 ADV23545.1 - 6e-142 473.9 0.0 7.7e-142 473.5 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 ADV23545.1 - 5.3e-39 133.5 0.0 1e-38 132.6 0.0 1.5 1 0 0 1 1 1 1 Aconitase C-terminal domain DUF521 PF04412.13 ADV23545.1 - 0.0037 16.0 0.0 0.0057 15.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF521) UAA PF08449.11 ADV23546.1 - 8.6e-08 31.7 14.6 1.3e-07 31.1 14.6 1.2 1 0 0 1 1 1 1 UAA transporter family PHD PF00628.29 ADV23547.1 - 0.0037 17.1 6.9 0.097 12.6 6.9 2.4 1 1 0 1 1 1 1 PHD-finger Acetone_carb_G PF08882.11 ADV23547.1 - 0.017 15.3 0.1 0.034 14.3 0.1 1.5 1 0 0 1 1 1 0 Acetone carboxylase gamma subunit zf-H2C2_2 PF13465.6 ADV23547.1 - 0.61 10.6 5.8 23 5.6 0.1 2.7 2 0 0 2 2 2 0 Zinc-finger double domain F-box_4 PF15966.5 ADV23549.1 - 0.00058 19.7 0.0 0.0012 18.7 0.0 1.6 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 ADV23549.1 - 0.0016 18.3 1.3 0.0037 17.1 0.0 2.3 3 0 0 3 3 3 1 F-box-like zf-HC2 PF13490.6 ADV23549.1 - 0.08 13.2 0.2 0.27 11.5 0.0 1.9 2 0 0 2 2 2 0 Putative zinc-finger CRM1_C PF08767.11 ADV23550.1 - 4.2e-132 440.2 0.0 8.1e-131 435.9 0.0 2.6 2 0 0 2 2 2 1 CRM1 C terminal Xpo1 PF08389.12 ADV23550.1 - 1.8e-41 141.7 4.1 1.4e-40 138.8 3.5 3.0 3 0 0 3 3 3 1 Exportin 1-like protein CRM1_repeat_2 PF18784.1 ADV23550.1 - 5e-34 115.8 5.2 5e-34 115.8 5.2 2.1 2 0 0 2 2 2 1 CRM1 / Exportin repeat 2 CRM1_repeat_3 PF18787.1 ADV23550.1 - 5.8e-30 103.2 0.9 5.8e-30 103.2 0.9 2.6 3 0 0 3 3 3 1 CRM1 / Exportin repeat 3 CRM1_repeat PF18777.1 ADV23550.1 - 2.6e-19 68.4 3.2 5.8e-19 67.3 3.2 1.7 1 0 0 1 1 1 1 Chromosome region maintenance or exportin repeat IBN_N PF03810.19 ADV23550.1 - 1.9e-13 50.1 0.9 8.3e-13 48.1 0.4 2.5 2 0 0 2 2 2 1 Importin-beta N-terminal domain MMS19_C PF12460.8 ADV23550.1 - 0.0015 17.7 2.9 1 8.4 0.0 4.0 4 1 0 4 4 4 2 RNAPII transcription regulator C-terminal Adaptin_N PF01602.20 ADV23550.1 - 0.0056 15.3 0.1 4.2 5.8 0.0 3.0 2 1 0 2 2 2 2 Adaptin N terminal region V-ATPase_H_C PF11698.8 ADV23550.1 - 0.3 11.2 2.8 1.6 8.8 0.1 3.4 3 0 0 3 3 3 0 V-ATPase subunit H Baculo_PEP_C PF04513.12 ADV23551.1 - 0.023 14.7 0.1 0.043 13.9 0.1 1.3 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF2730 PF10805.8 ADV23551.1 - 0.094 12.8 1.1 0.23 11.6 0.7 2.0 2 1 1 3 3 3 0 Protein of unknown function (DUF2730) CCDC-167 PF15188.6 ADV23551.1 - 0.095 13.1 0.4 0.17 12.2 0.4 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 Glyco_hydro_18 PF00704.28 ADV23552.1 - 3.7e-65 220.7 0.7 1e-47 163.4 0.1 2.1 1 1 1 2 2 2 2 Glycosyl hydrolases family 18 POT1PC PF16686.5 ADV23553.1 - 0.0069 16.3 0.0 0.012 15.5 0.0 1.3 1 0 0 1 1 1 1 ssDNA-binding domain of telomere protection protein HSF_DNA-bind PF00447.17 ADV23554.1 - 2.6e-26 92.1 1.6 8.3e-26 90.4 0.8 2.2 2 0 0 2 2 2 1 HSF-type DNA-binding Response_reg PF00072.24 ADV23554.1 - 9e-22 77.4 0.0 2.2e-21 76.1 0.0 1.7 1 0 0 1 1 1 1 Response regulator receiver domain Rhomboid_N PF12122.8 ADV23556.1 - 0.024 14.8 0.0 0.046 13.9 0.0 1.4 1 0 0 1 1 1 0 Cytoplasmic N-terminal domain of rhomboid serine protease Transcrip_reg PF01709.20 ADV23557.1 - 2.5e-68 230.1 0.0 3e-68 229.8 0.0 1.0 1 0 0 1 1 1 1 Transcriptional regulator Spore_YtfJ PF09579.10 ADV23557.1 - 0.14 12.3 0.0 0.28 11.4 0.0 1.5 1 0 0 1 1 1 0 Sporulation protein YtfJ (Spore_YtfJ) Med1 PF10744.9 ADV23558.1 - 0.012 14.7 0.4 0.18 10.8 0.1 2.4 2 0 0 2 2 2 0 Mediator of RNA polymerase II transcription subunit 1 SAPS PF04499.15 ADV23559.1 - 7.4e-137 457.1 0.0 1.3e-136 456.3 0.0 1.4 1 0 0 1 1 1 1 SIT4 phosphatase-associated protein YlbD_coat PF14071.6 ADV23559.1 - 0.027 14.7 0.3 0.071 13.4 0.3 1.6 1 0 0 1 1 1 0 Putative coat protein PEX11 PF05648.14 ADV23560.1 - 1.2e-09 38.0 0.1 1.1e-07 31.6 0.0 2.4 2 1 0 2 2 2 2 Peroxisomal biogenesis factor 11 (PEX11) SUFU PF05076.13 ADV23560.1 - 0.16 11.9 0.0 0.28 11.2 0.0 1.5 1 0 0 1 1 1 0 Suppressor of fused protein (SUFU) 4HBT_3 PF13622.6 ADV23561.1 - 6.1e-42 144.6 0.2 1.4e-41 143.4 0.2 1.5 1 1 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.15 ADV23561.1 - 1.1e-13 51.2 0.0 2.8e-11 43.4 0.0 2.9 2 1 1 3 3 3 1 Acyl-CoA thioesterase TruB_C PF09142.11 ADV23561.1 - 0.016 14.9 0.2 0.043 13.6 0.2 1.6 1 1 0 1 1 1 0 tRNA Pseudouridine synthase II, C terminal She9_MDM33 PF05546.11 ADV23562.1 - 1.4e-72 243.7 6.9 1.9e-72 243.3 6.9 1.1 1 0 0 1 1 1 1 She9 / Mdm33 family DUF2621 PF11084.8 ADV23562.1 - 0.16 11.9 0.3 1.3 9.0 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2621) PHF12_MRG_bd PF16737.5 ADV23563.1 - 0.12 12.2 0.0 0.25 11.1 0.0 1.6 1 0 0 1 1 1 0 PHD finger protein 12 MRG binding domain DsbC_N PF10411.9 ADV23565.1 - 0.17 11.4 0.0 0.35 10.3 0.0 1.5 1 0 0 1 1 1 0 Disulfide bond isomerase protein N-terminus FUSC_2 PF13515.6 ADV23566.1 - 5.6e-11 42.7 7.3 5.6e-11 42.7 7.3 2.9 2 2 0 2 2 2 1 Fusaric acid resistance protein-like ArAE_2 PF10334.9 ADV23566.1 - 6e-09 36.1 0.1 4.7e-07 29.9 0.0 2.4 2 0 0 2 2 2 1 Aromatic acid exporter family member 2 ALMT PF11744.8 ADV23566.1 - 0.0002 20.3 4.0 0.14 10.9 0.0 2.2 2 0 0 2 2 2 2 Aluminium activated malate transporter FUSC PF04632.12 ADV23566.1 - 0.07 11.7 4.0 0.094 11.2 0.0 2.7 2 1 1 3 3 3 0 Fusaric acid resistance protein family FUSC-like PF12805.7 ADV23566.1 - 8.2 5.4 16.7 0.18 10.9 0.5 2.8 4 0 0 4 4 4 0 FUSC-like inner membrane protein yccS Abhydrolase_6 PF12697.7 ADV23567.1 - 1.1e-05 26.2 0.7 0.00013 22.6 0.1 2.1 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 ADV23567.1 - 0.019 14.6 0.0 0.041 13.5 0.0 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold Calpain_inhib PF00748.19 ADV23567.1 - 0.12 12.9 0.8 0.22 12.0 0.8 1.4 1 0 0 1 1 1 0 Calpain inhibitor Acetyltransf_1 PF00583.25 ADV23568.1 - 5.8e-07 29.8 0.0 0.00023 21.4 0.0 2.1 2 0 0 2 2 2 2 Acetyltransferase (GNAT) family FR47 PF08445.10 ADV23568.1 - 5.2e-06 26.3 0.0 0.04 13.9 0.0 2.3 2 0 0 2 2 2 2 FR47-like protein Acetyltransf_7 PF13508.7 ADV23568.1 - 1.5e-05 25.4 0.0 3.1e-05 24.3 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ADV23568.1 - 0.00025 21.0 0.0 0.18 11.7 0.0 2.2 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Rpp20 PF12328.8 ADV23569.1 - 2.4e-05 24.3 0.8 0.00063 19.7 0.0 2.9 1 1 2 3 3 3 1 Rpp20 subunit of nuclear RNase MRP and P DUF3774 PF12609.8 ADV23569.1 - 0.29 12.2 1.5 0.55 11.3 1.5 1.5 1 0 0 1 1 1 0 Wound-induced protein FHA PF00498.26 ADV23570.1 - 1.1e-13 51.3 0.0 2.1e-13 50.4 0.0 1.5 1 0 0 1 1 1 1 FHA domain zf-RING_11 PF17123.5 ADV23570.1 - 6.9e-11 41.7 12.7 1.2e-10 40.9 12.7 1.4 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_2 PF13639.6 ADV23570.1 - 1.5e-07 31.6 12.4 2.4e-07 31.0 12.4 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 ADV23570.1 - 0.0014 18.9 7.4 0.0029 17.9 7.4 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 ADV23570.1 - 0.0032 17.3 12.9 0.0055 16.5 12.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 ADV23570.1 - 0.0044 17.0 4.2 0.0082 16.2 4.2 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4 PF00097.25 ADV23570.1 - 0.014 15.3 11.9 0.024 14.5 11.9 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ADV23570.1 - 0.038 14.0 10.0 0.073 13.1 10.0 1.5 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_UBOX PF13445.6 ADV23570.1 - 0.34 11.0 11.7 0.79 9.8 11.7 1.7 1 0 0 1 1 1 0 RING-type zinc-finger Prok-RING_4 PF14447.6 ADV23570.1 - 1 9.3 10.2 2 8.3 10.2 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Zn_ribbon_17 PF17120.5 ADV23570.1 - 2.3 7.9 8.6 3.9 7.2 8.6 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type PHD PF00628.29 ADV23570.1 - 5.5 7.0 7.7 9.9 6.1 7.7 1.4 1 0 0 1 1 1 0 PHD-finger Cpn60_TCP1 PF00118.24 ADV23573.1 - 1e-154 515.8 15.3 1.2e-154 515.6 15.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Pil1 PF13805.6 ADV23574.1 - 9.7e-26 90.8 0.1 1.4e-25 90.3 0.1 1.2 1 0 0 1 1 1 1 Eisosome component PIL1 IFT57 PF10498.9 ADV23574.1 - 1.5 7.7 7.3 0.14 11.1 2.0 1.8 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 Fez1 PF06818.15 ADV23574.1 - 5.2 7.5 9.7 0.088 13.3 2.6 1.6 2 0 0 2 2 2 0 Fez1 Cu-oxidase_2 PF07731.14 ADV23575.1 - 6.2e-30 103.7 0.2 4.1e-27 94.6 0.1 2.4 2 0 0 2 2 2 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 ADV23575.1 - 9.3e-23 80.5 0.7 3.8e-22 78.5 0.1 2.2 2 1 0 2 2 2 1 Multicopper oxidase Cu-oxidase PF00394.22 ADV23575.1 - 3.2e-12 46.8 0.0 5.6e-12 46.1 0.0 1.3 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 ADV23576.1 - 1.1e-33 115.8 3.7 3.9e-30 104.4 0.1 2.7 2 1 1 3 3 3 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 ADV23576.1 - 6.7e-23 81.0 4.1 7.1e-22 77.7 1.0 3.0 2 1 1 3 3 3 1 Multicopper oxidase Cu-oxidase PF00394.22 ADV23576.1 - 6.3e-18 65.4 0.0 1.8e-16 60.7 0.0 2.1 2 0 0 2 2 2 1 Multicopper oxidase F-box-like PF12937.7 ADV23577.1 - 0.002 18.0 0.2 0.002 18.0 0.2 2.0 2 0 0 2 2 2 1 F-box-like BPL_LplA_LipB PF03099.19 ADV23578.1 - 2.9e-06 27.2 0.0 5.6e-06 26.3 0.0 1.5 1 1 0 1 1 1 1 Biotin/lipoate A/B protein ligase family Cu_amine_oxid PF01179.20 ADV23579.1 - 2e-105 353.1 9.2 2e-91 306.9 5.1 2.1 1 1 1 2 2 2 2 Copper amine oxidase, enzyme domain DUF1965 PF09248.10 ADV23579.1 - 6.3e-29 99.6 0.3 1.5e-28 98.4 0.3 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1965) Cu_amine_oxidN2 PF02727.16 ADV23579.1 - 6.5e-06 26.3 0.0 1.3e-05 25.3 0.0 1.4 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain AhpC-TSA PF00578.21 ADV23580.1 - 2.3e-38 130.9 0.0 3.1e-38 130.5 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 ADV23580.1 - 3.8e-16 59.1 0.0 4.7e-16 58.8 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 ADV23580.1 - 8.2e-11 41.6 0.0 1.8e-10 40.5 0.0 1.6 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin SCO1-SenC PF02630.14 ADV23580.1 - 0.042 13.8 0.1 0.17 11.8 0.0 1.8 2 0 0 2 2 2 0 SCO1/SenC MIS13 PF08202.11 ADV23581.1 - 5.5e-30 104.7 1.7 1.1e-29 103.7 1.7 1.4 1 0 0 1 1 1 1 Mis12-Mtw1 protein family DnaJ PF00226.31 ADV23582.1 - 1.3e-18 66.8 0.2 1.3e-18 66.8 0.2 2.3 3 0 0 3 3 3 1 DnaJ domain dsRBD2 PF17842.1 ADV23582.1 - 0.054 13.7 1.0 0.32 11.2 0.0 2.4 2 0 0 2 2 2 0 Double-stranded RNA binding domain 2 Apis_Csd PF11671.8 ADV23582.1 - 6.3 6.8 6.6 0.69 9.9 1.2 2.1 2 0 0 2 2 2 0 Complementary sex determiner protein RRM_1 PF00076.22 ADV23583.1 - 1.6e-13 50.3 0.3 6.1e-13 48.4 0.0 2.1 2 1 1 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RING_5 PF14634.6 ADV23584.1 - 0.0025 17.7 0.1 0.0082 16.1 0.2 1.8 1 1 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 ADV23584.1 - 0.049 13.7 0.5 0.37 10.9 0.7 2.2 1 1 1 2 2 2 0 RING-type zinc-finger zf-RING_2 PF13639.6 ADV23584.1 - 0.16 12.3 0.2 0.46 10.9 0.1 1.8 1 1 0 1 1 1 0 Ring finger domain Prok-RING_4 PF14447.6 ADV23584.1 - 0.76 9.7 2.5 8.2 6.4 0.1 2.5 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 NUDIX_2 PF13869.6 ADV23585.1 - 1.9e-50 171.0 0.0 4.2e-50 169.9 0.0 1.5 1 1 0 1 1 1 1 Nucleotide hydrolase NUDIX PF00293.28 ADV23585.1 - 0.013 15.5 0.0 0.018 15.1 0.0 1.3 1 0 0 1 1 1 0 NUDIX domain PAF-AH_p_II PF03403.13 ADV23587.1 - 3.2e-44 151.0 0.0 4e-44 150.7 0.0 1.1 1 0 0 1 1 1 1 Platelet-activating factor acetylhydrolase, isoform II Chlorophyllase2 PF12740.7 ADV23587.1 - 3.1e-09 36.1 0.0 2.9e-06 26.4 0.0 2.1 2 0 0 2 2 2 2 Chlorophyllase enzyme Hydrolase_4 PF12146.8 ADV23587.1 - 5.8e-06 25.8 0.0 0.0032 16.8 0.0 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Chlorophyllase PF07224.11 ADV23587.1 - 0.00072 18.7 0.0 0.0028 16.7 0.0 1.8 2 0 0 2 2 2 1 Chlorophyllase Abhydrolase_1 PF00561.20 ADV23587.1 - 0.067 12.8 0.0 0.66 9.6 0.0 2.1 1 1 0 1 1 1 0 alpha/beta hydrolase fold DLH PF01738.18 ADV23587.1 - 0.16 11.5 0.0 0.44 10.1 0.0 1.7 1 1 1 2 2 2 0 Dienelactone hydrolase family Abhydrolase_6 PF12697.7 ADV23587.1 - 0.88 10.1 5.1 0.57 10.7 2.5 2.0 1 1 1 2 2 2 0 Alpha/beta hydrolase family WW PF00397.26 ADV23588.1 - 9.2e-11 41.6 0.5 1.7e-10 40.8 0.5 1.4 1 0 0 1 1 1 1 WW domain DUF4407 PF14362.6 ADV23588.1 - 2.4 7.4 4.5 3.3 7.0 4.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) HbrB PF08539.11 ADV23589.1 - 7.2e-33 114.0 0.1 1.5e-32 112.9 0.1 1.6 1 0 0 1 1 1 1 HbrB-like CorA PF01544.18 ADV23590.1 - 8.8e-45 153.3 0.1 1.3e-44 152.7 0.1 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein Baculo_PEP_C PF04513.12 ADV23590.1 - 0.021 14.9 0.3 0.036 14.1 0.3 1.2 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus A_thal_3526 PF09713.10 ADV23590.1 - 0.1 12.9 0.0 0.21 11.9 0.0 1.5 1 0 0 1 1 1 0 Plant protein 1589 of unknown function (A_thal_3526) Yip1 PF04893.17 ADV23593.1 - 1.7e-08 34.4 9.5 2.5e-08 33.8 9.5 1.3 1 0 0 1 1 1 1 Yip1 domain Ribosomal_L36e PF01158.18 ADV23594.1 - 1.9e-35 121.0 7.2 2.1e-35 120.8 7.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L36e 4HB_MCP_1 PF12729.7 ADV23594.1 - 0.007 15.9 0.3 0.0089 15.6 0.3 1.1 1 0 0 1 1 1 1 Four helix bundle sensory module for signal transduction DUF2207 PF09972.9 ADV23594.1 - 0.11 11.2 0.5 0.13 11.0 0.5 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Mit_KHE1 PF10173.9 ADV23595.1 - 4.1e-46 157.5 0.6 4.1e-46 157.5 0.6 1.5 2 0 0 2 2 2 1 Mitochondrial K+-H+ exchange-related HAD PF12710.7 ADV23596.1 - 5.3e-23 82.4 0.0 7.2e-23 82.0 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.12 ADV23596.1 - 0.0013 18.2 0.0 0.0058 16.0 0.0 1.8 2 0 0 2 2 2 1 Putative Phosphatase Hydrolase PF00702.26 ADV23596.1 - 0.0026 18.1 0.3 0.31 11.3 0.0 2.8 1 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 ADV23596.1 - 0.022 14.8 0.0 1.5 8.9 0.0 2.4 2 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase UMPH-1 PF05822.12 ADV23596.1 - 0.093 12.2 0.0 0.15 11.6 0.0 1.4 1 1 0 1 1 1 0 Pyrimidine 5'-nucleotidase (UMPH-1) Peptidase_M24 PF00557.24 ADV23597.1 - 8.5e-35 120.3 0.0 1.2e-34 119.8 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N_2 PF16189.5 ADV23597.1 - 2.9e-30 105.5 0.0 2.1e-29 102.7 0.0 2.3 3 0 0 3 3 3 1 Creatinase/Prolidase N-terminal domain Peptidase_M24_C PF16188.5 ADV23597.1 - 8.5e-22 77.0 3.4 7e-20 70.9 0.9 2.8 2 0 0 2 2 2 2 C-terminal region of peptidase_M24 Creatinase_N PF01321.18 ADV23597.1 - 3.3e-20 73.1 0.0 1e-18 68.2 0.0 2.4 2 0 0 2 2 2 1 Creatinase/Prolidase N-terminal domain SUIM_assoc PF16619.5 ADV23599.1 - 0.15 12.1 0.0 0.26 11.4 0.0 1.4 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 UbiD PF01977.16 ADV23600.1 - 1.3e-114 383.3 0.0 1.5e-114 383.1 0.0 1.0 1 0 0 1 1 1 1 3-octaprenyl-4-hydroxybenzoate carboxy-lyase TFIIS_C PF01096.18 ADV23601.1 - 5.7e-22 77.3 8.8 5.7e-22 77.3 8.8 2.7 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) zinc_ribbon_9 PF14369.6 ADV23601.1 - 0.00012 22.3 8.4 0.01 16.1 0.5 3.3 3 0 0 3 3 3 2 zinc-ribbon zf-ribbon_3 PF13248.6 ADV23601.1 - 0.00033 19.9 13.5 0.16 11.4 0.3 4.1 4 0 0 4 4 4 2 zinc-ribbon domain Zn_Tnp_IS1595 PF12760.7 ADV23601.1 - 0.0023 17.9 3.9 0.0023 17.9 3.9 3.2 2 1 1 3 3 3 1 Transposase zinc-ribbon domain RNA_POL_M_15KD PF02150.16 ADV23601.1 - 0.013 15.4 0.6 0.013 15.4 0.6 3.0 3 0 0 3 3 3 0 RNA polymerases M/15 Kd subunit TF_Zn_Ribbon PF08271.12 ADV23601.1 - 0.018 14.6 9.9 0.37 10.4 0.9 2.5 2 1 0 2 2 2 0 TFIIB zinc-binding PhnA_Zn_Ribbon PF08274.12 ADV23601.1 - 0.024 14.6 13.8 0.35 10.9 3.2 3.2 2 2 0 2 2 2 0 PhnA Zinc-Ribbon zf-RRPl_C4 PF17026.5 ADV23601.1 - 0.031 14.4 2.3 0.042 13.9 2.3 1.2 1 0 0 1 1 1 0 Putative ribonucleoprotein zinc-finger pf C4 type DZR PF12773.7 ADV23601.1 - 0.049 13.7 11.9 0.15 12.1 0.3 2.7 2 1 0 2 2 2 0 Double zinc ribbon zf-ZPR1 PF03367.13 ADV23601.1 - 0.066 13.1 0.3 0.066 13.1 0.3 1.6 2 0 0 2 2 2 0 ZPR1 zinc-finger domain Lar_restr_allev PF14354.6 ADV23601.1 - 0.63 10.5 9.6 0.5 10.8 2.2 2.4 2 1 0 2 2 2 0 Restriction alleviation protein Lar zf-Di19 PF05605.12 ADV23601.1 - 2.9 8.2 11.6 9.3 6.6 0.4 3.4 3 1 1 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding Zn-ribbon_8 PF09723.10 ADV23601.1 - 3.9 7.7 19.7 2.7 8.2 0.5 3.8 3 2 1 4 4 4 0 Zinc ribbon domain zf-C2H2_4 PF13894.6 ADV23601.1 - 4.7 8.3 12.7 40 5.4 0.1 4.2 4 0 0 4 4 4 0 C2H2-type zinc finger zinc_ribbon_4 PF13717.6 ADV23601.1 - 8.3 6.4 14.4 8 6.5 1.7 3.8 4 0 0 4 4 4 0 zinc-ribbon domain Mito_carr PF00153.27 ADV23602.1 - 1.3e-45 153.3 1.7 1.3e-16 60.3 0.1 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein Peptidase_C62 PF12380.8 ADV23602.1 - 0.06 12.5 0.0 0.09 11.9 0.0 1.2 1 0 0 1 1 1 0 Gill-associated viral 3C-like peptidase DUF2458 PF10454.9 ADV23603.1 - 1.9e-05 24.4 1.6 2.6e-05 23.9 1.5 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF2458) AP1AR PF15745.5 ADV23603.1 - 0.011 15.4 0.7 0.014 15.1 0.7 1.1 1 0 0 1 1 1 0 AP-1 complex-associated regulatory protein Abhydrolase_2 PF02230.16 ADV23604.1 - 4.4e-09 36.5 0.0 7.1e-09 35.8 0.0 1.2 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Flavoprotein PF02441.19 ADV23605.1 - 4.4e-23 81.8 0.0 5.4e-23 81.5 0.0 1.0 1 0 0 1 1 1 1 Flavoprotein Ral PF11058.8 ADV23605.1 - 0.15 11.7 0.1 0.36 10.4 0.1 1.7 1 0 0 1 1 1 0 Antirestriction protein Ral Pyr_redox_2 PF07992.14 ADV23606.1 - 9.9e-45 153.0 0.0 1.7e-44 152.2 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ADV23606.1 - 2.3e-16 60.1 0.3 1e-10 42.0 0.1 3.6 3 1 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase EF-hand_1 PF00036.32 ADV23606.1 - 2.9e-11 42.1 5.8 1.7e-05 24.1 0.7 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 ADV23606.1 - 3.9e-09 36.8 2.1 8.1e-09 35.8 2.1 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 ADV23606.1 - 3.3e-08 32.8 2.5 0.005 16.7 0.2 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 ADV23606.1 - 2.3e-06 26.8 4.0 0.00032 20.0 0.4 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 ADV23606.1 - 8.5e-05 22.3 4.0 0.0012 18.7 1.7 2.5 1 1 1 2 2 2 2 EF-hand domain pair Pyr_redox_3 PF13738.6 ADV23606.1 - 0.0022 17.3 3.3 0.78 8.9 4.1 3.1 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase EF-hand_4 PF12763.7 ADV23606.1 - 0.05 13.6 1.2 0.27 11.2 0.6 2.4 2 1 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand TerB PF05099.13 ADV23606.1 - 0.079 12.9 0.1 0.16 11.9 0.1 1.5 1 0 0 1 1 1 0 Tellurite resistance protein TerB NAD_binding_8 PF13450.6 ADV23606.1 - 0.085 13.1 0.0 7.8 6.8 0.0 2.6 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain DUF5109 PF17134.4 ADV23606.1 - 0.13 12.2 0.2 0.29 11.1 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5109) zf-CCHC PF00098.23 ADV23607.1 - 0.043 13.9 0.4 0.08 13.1 0.4 1.4 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_3 PF13917.6 ADV23607.1 - 0.081 12.9 0.1 0.16 12.0 0.1 1.4 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_2 PF13696.6 ADV23607.1 - 0.1 12.4 2.1 0.1 12.4 2.1 1.5 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_5 PF14787.6 ADV23607.1 - 4.1 7.2 7.5 0.26 11.0 1.7 1.8 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger RRP7 PF12923.7 ADV23609.1 - 3.4e-27 94.9 0.1 3.4e-27 94.9 0.1 2.1 2 0 0 2 2 1 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain RRM_Rrp7 PF17799.1 ADV23609.1 - 6.8e-07 29.2 0.1 6.5e-06 26.0 0.1 2.2 1 1 0 1 1 1 1 Rrp7 RRM-like N-terminal domain RRM_1 PF00076.22 ADV23609.1 - 2.1e-06 27.5 0.0 4.2e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CENP-B_dimeris PF09026.10 ADV23609.1 - 0.00086 19.7 11.1 0.0019 18.6 11.1 1.5 1 0 0 1 1 1 1 Centromere protein B dimerisation domain BUD22 PF09073.10 ADV23609.1 - 0.0011 18.4 3.0 0.0011 18.4 3.0 1.8 2 0 0 2 2 2 1 BUD22 RRM_7 PF16367.5 ADV23609.1 - 0.014 15.5 0.1 0.041 14.0 0.1 1.8 1 0 0 1 1 1 0 RNA recognition motif CDC45 PF02724.14 ADV23609.1 - 0.019 13.3 3.6 0.028 12.7 3.6 1.2 1 0 0 1 1 1 0 CDC45-like protein RNase_H2_suC PF08615.11 ADV23609.1 - 0.031 14.4 0.0 0.034 14.3 0.0 1.4 1 0 0 1 1 1 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) RXT2_N PF08595.11 ADV23609.1 - 0.14 12.2 4.2 0.26 11.3 4.2 1.4 1 0 0 1 1 1 0 RXT2-like, N-terminal PPP4R2 PF09184.11 ADV23609.1 - 0.17 11.4 6.7 0.28 10.7 6.7 1.2 1 0 0 1 1 1 0 PPP4R2 DNA_pol_phi PF04931.13 ADV23609.1 - 0.22 9.6 13.0 0.3 9.2 13.0 1.1 1 0 0 1 1 1 0 DNA polymerase phi Nop14 PF04147.12 ADV23609.1 - 0.32 9.2 8.5 0.49 8.6 8.5 1.2 1 0 0 1 1 1 0 Nop14-like family NOA36 PF06524.12 ADV23609.1 - 0.71 9.1 13.4 1.7 7.9 13.4 1.6 1 0 0 1 1 1 0 NOA36 protein FAM176 PF14851.6 ADV23609.1 - 1.2 8.8 9.0 0.092 12.4 3.9 1.7 2 0 0 2 2 2 0 FAM176 family DUF4611 PF15387.6 ADV23609.1 - 1.3 9.3 11.7 3.5 7.9 11.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) RRN3 PF05327.11 ADV23609.1 - 7 5.1 6.9 10 4.5 6.9 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DUF4637 PF15470.6 ADV23609.1 - 8.5 6.1 8.5 17 5.1 8.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Biotin_lipoyl PF00364.22 ADV23611.1 - 2.1e-17 62.7 3.5 3.8e-17 61.9 3.5 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 ADV23611.1 - 5.2e-07 29.9 0.0 1.8e-06 28.2 0.0 2.0 1 0 0 1 1 1 1 e3 binding domain DUF1631 PF07793.11 ADV23611.1 - 0.02 13.3 2.7 0.028 12.9 2.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1631) BAR_2 PF10455.9 ADV23611.1 - 4.5 6.3 6.2 9.2 5.3 6.3 1.4 1 1 0 1 1 1 0 Bin/amphiphysin/Rvs domain for vesicular trafficking Peptidase_M16 PF00675.20 ADV23612.1 - 1.3e-52 177.7 0.2 3.2e-52 176.5 0.2 1.7 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 ADV23612.1 - 2.4e-36 125.5 0.0 1.7e-33 116.2 0.0 3.0 3 0 0 3 3 3 2 Peptidase M16 inactive domain M16C_assoc PF08367.11 ADV23612.1 - 0.057 12.5 0.1 0.1 11.7 0.1 1.4 1 0 0 1 1 1 0 Peptidase M16C associated RbsD_FucU PF05025.13 ADV23612.1 - 0.14 12.6 0.4 0.49 10.8 0.1 2.0 2 0 0 2 2 2 0 RbsD / FucU transport protein family Peptidase_S78_2 PF14550.6 ADV23612.1 - 0.21 11.7 0.6 0.9 9.6 0.0 2.1 2 0 0 2 2 2 0 Putative phage serine protease XkdF ABC_membrane PF00664.23 ADV23615.1 - 7.6e-62 209.4 32.6 1.1e-31 110.5 12.7 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 ADV23615.1 - 6.3e-50 169.2 0.7 1.4e-26 93.6 0.2 2.9 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 ADV23615.1 - 8.7e-08 31.9 10.2 6.3e-05 22.5 2.9 3.8 2 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 ADV23615.1 - 3.1e-05 24.4 0.4 0.014 15.8 0.1 2.7 2 1 0 2 2 2 1 AAA ATPase domain MMR_HSR1 PF01926.23 ADV23615.1 - 7.8e-05 22.7 4.1 0.18 11.9 0.2 3.4 3 0 0 3 3 3 2 50S ribosome-binding GTPase AAA_29 PF13555.6 ADV23615.1 - 0.00011 21.9 4.4 0.04 13.6 0.1 3.5 3 0 0 3 3 3 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 ADV23615.1 - 0.00036 20.5 3.7 0.024 14.6 0.2 3.1 3 0 0 3 3 3 1 RsgA GTPase AAA_15 PF13175.6 ADV23615.1 - 0.00053 19.8 1.3 0.66 9.6 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain AAA_21 PF13304.6 ADV23615.1 - 0.001 18.9 0.6 1 9.1 0.0 3.2 2 1 1 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system Dynamin_N PF00350.23 ADV23615.1 - 0.002 18.2 0.6 0.68 10.0 0.0 2.8 2 0 0 2 2 2 1 Dynamin family AAA_23 PF13476.6 ADV23615.1 - 0.003 18.1 8.5 0.16 12.4 0.2 4.0 4 0 0 4 4 4 2 AAA domain AAA_22 PF13401.6 ADV23615.1 - 0.0078 16.5 0.8 2.3 8.5 0.0 3.2 2 1 0 2 2 2 1 AAA domain Roc PF08477.13 ADV23615.1 - 0.014 15.6 0.3 6.2 7.1 0.0 2.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase NACHT PF05729.12 ADV23615.1 - 0.033 14.1 0.8 0.25 11.2 0.0 2.8 3 0 0 3 3 3 0 NACHT domain AAA_30 PF13604.6 ADV23615.1 - 0.048 13.4 1.0 6.7 6.4 0.1 2.8 2 1 0 2 2 2 0 AAA domain AAA_7 PF12775.7 ADV23615.1 - 0.051 13.1 1.5 3.9 6.9 0.1 2.8 3 0 0 3 3 3 0 P-loop containing dynein motor region AAA_18 PF13238.6 ADV23615.1 - 0.063 13.8 0.2 19 5.8 0.0 2.8 2 0 0 2 2 2 0 AAA domain MeaB PF03308.16 ADV23615.1 - 0.14 11.1 0.5 1.1 8.2 0.0 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB FtsK_SpoIIIE PF01580.18 ADV23615.1 - 0.17 11.3 2.3 1.1 8.6 0.1 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family TrwB_AAD_bind PF10412.9 ADV23615.1 - 0.23 10.3 2.1 0.54 9.1 0.2 2.1 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain Zeta_toxin PF06414.12 ADV23615.1 - 0.28 10.4 3.4 2.6 7.3 0.1 2.6 3 0 0 3 3 3 0 Zeta toxin TsaE PF02367.17 ADV23615.1 - 0.52 10.3 1.7 3.6 7.6 0.2 2.8 3 0 0 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF87 PF01935.17 ADV23615.1 - 2.7 8.0 7.5 1 9.4 0.5 2.9 3 0 0 3 3 2 0 Helicase HerA, central domain Peptidase_M24 PF00557.24 ADV23617.1 - 1.5e-43 148.9 0.0 1.9e-43 148.6 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 Ferric_reduct PF01794.19 ADV23618.1 - 9e-22 77.5 11.1 9e-22 77.5 11.1 2.5 3 0 0 3 3 3 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 ADV23618.1 - 4.7e-13 49.2 0.0 9.3e-13 48.2 0.0 1.5 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 ADV23618.1 - 4.8e-09 36.5 0.0 1.7e-08 34.7 0.0 1.8 1 1 0 1 1 1 1 Ferric reductase NAD binding domain DUF2970 PF11174.8 ADV23618.1 - 0.0048 16.7 0.2 0.0048 16.7 0.2 2.6 2 1 1 3 3 3 1 Protein of unknown function (DUF2970) DUF4405 PF14358.6 ADV23618.1 - 7.9 7.1 17.0 0.3 11.6 0.4 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4405) TRAPP PF04051.16 ADV23619.1 - 4.9e-22 78.2 0.0 6.5e-22 77.8 0.0 1.2 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component SAP PF02037.27 ADV23620.1 - 5.5e-11 42.0 4.0 1e-10 41.1 4.0 1.5 1 0 0 1 1 1 1 SAP domain HeH PF12949.7 ADV23620.1 - 0.071 12.8 0.1 0.14 11.9 0.1 1.5 1 0 0 1 1 1 0 HeH/LEM domain RR_TM4-6 PF06459.12 ADV23620.1 - 5.4 6.8 9.3 8.6 6.1 9.3 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF2070 PF09843.9 ADV23621.1 - 1.9 6.7 13.4 2.7 6.2 13.4 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Pro_isomerase PF00160.21 ADV23622.1 - 1.4e-47 161.9 0.1 1.7e-47 161.6 0.1 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD MFS_1 PF07690.16 ADV23623.1 - 4e-42 144.4 32.8 4e-42 144.4 32.8 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ADV23623.1 - 1.4e-12 47.2 6.4 1.4e-12 47.2 6.4 2.8 2 1 1 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.13 ADV23623.1 - 6.2e-10 38.1 2.9 1e-09 37.4 2.9 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_4 PF06779.14 ADV23623.1 - 1.4e-06 27.9 0.9 1.4e-06 27.9 0.9 2.2 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB PAP2 PF01569.21 ADV23623.1 - 1.1 9.0 10.5 0.064 13.0 4.0 2.3 2 0 0 2 2 2 0 PAP2 superfamily CHD5 PF04420.14 ADV23624.1 - 5e-59 198.7 3.0 5.8e-59 198.5 3.0 1.0 1 0 0 1 1 1 1 CHD5-like protein Exostosin PF03016.15 ADV23625.1 - 1.6e-53 181.9 0.0 2.2e-53 181.4 0.0 1.2 1 0 0 1 1 1 1 Exostosin family Epimerase PF01370.21 ADV23625.1 - 5.8e-18 65.2 0.0 8.5e-18 64.7 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ADV23625.1 - 6.9e-07 29.0 0.0 1.6e-06 27.8 0.0 1.6 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 ADV23625.1 - 9.9e-07 28.1 0.0 3.1e-06 26.5 0.0 1.8 1 1 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.19 ADV23625.1 - 3.4e-06 26.3 0.0 7.3e-06 25.2 0.0 1.4 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 ADV23625.1 - 0.07 12.2 0.0 2 7.5 0.0 2.7 3 0 0 3 3 3 0 Polysaccharide biosynthesis protein DUF3932 PF13068.6 ADV23625.1 - 0.16 12.3 0.2 0.86 9.9 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3932) BRD4_CDT PF17105.5 ADV23626.1 - 3.2 7.4 5.1 8.8 6.0 5.1 1.7 1 0 0 1 1 1 0 C-terminal domain of bromodomain protein 4 Sacchrp_dh_C PF16653.5 ADV23627.1 - 1.7e-79 267.7 0.0 1.2e-77 261.6 0.0 2.2 1 1 0 1 1 1 1 Saccharopine dehydrogenase C-terminal domain Spermine_synth PF01564.17 ADV23627.1 - 3e-68 229.0 0.0 8.7e-68 227.4 0.0 1.8 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Sacchrp_dh_NADP PF03435.18 ADV23627.1 - 4.2e-26 91.7 0.3 7.8e-25 87.6 0.1 2.3 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain Spermine_synt_N PF17284.2 ADV23627.1 - 1.4e-24 85.8 0.2 3.1e-24 84.6 0.2 1.7 1 0 0 1 1 1 1 Spermidine synthase tetramerisation domain Methyltransf_25 PF13649.6 ADV23627.1 - 1.6e-09 38.3 0.0 7.4e-06 26.6 0.0 3.5 3 0 0 3 3 3 1 Methyltransferase domain Shikimate_DH PF01488.20 ADV23627.1 - 3.3e-07 30.5 0.4 3.9e-06 27.0 0.0 2.4 2 1 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase NAD_binding_10 PF13460.6 ADV23627.1 - 1.2e-06 28.6 0.1 2.1e-06 27.8 0.1 1.5 1 0 0 1 1 1 1 NAD(P)H-binding Methyltransf_11 PF08241.12 ADV23627.1 - 3.3e-05 24.5 0.0 0.059 14.0 0.0 3.5 3 0 0 3 3 3 1 Methyltransferase domain AlaDh_PNT_C PF01262.21 ADV23627.1 - 0.00019 20.8 0.0 0.0055 16.0 0.0 2.2 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain Methyltransf_12 PF08242.12 ADV23627.1 - 0.00027 21.6 0.0 0.0077 16.9 0.0 3.1 3 1 0 3 3 3 1 Methyltransferase domain MTS PF05175.14 ADV23627.1 - 0.00061 19.4 0.0 0.028 14.0 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase small domain F420_oxidored PF03807.17 ADV23627.1 - 0.0007 20.1 0.0 0.0017 18.9 0.0 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_3 PF03447.16 ADV23627.1 - 0.0048 17.5 0.0 0.015 15.9 0.0 1.9 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain DUF43 PF01861.16 ADV23627.1 - 0.037 13.2 0.0 0.075 12.2 0.0 1.4 1 0 0 1 1 1 0 Branched-chain polyamine synthase A C-terminal domain Methyltransf_2 PF00891.18 ADV23627.1 - 0.049 12.9 0.0 0.11 11.8 0.0 1.6 1 0 0 1 1 1 0 O-methyltransferase domain Methyltransf_30 PF05430.11 ADV23627.1 - 0.09 12.7 0.0 0.2 11.5 0.0 1.6 1 0 0 1 1 1 0 S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_18 PF12847.7 ADV23627.1 - 0.095 12.6 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain MFS_1 PF07690.16 ADV23629.1 - 1.8e-25 89.6 63.9 6.6e-24 84.5 58.0 3.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Glyco_hydro_71 PF03659.14 ADV23630.1 - 9.5e-121 403.1 12.6 1.3e-120 402.7 12.6 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 71 WSC PF01822.19 ADV23630.1 - 1.9e-61 204.2 63.5 2.7e-21 75.5 12.3 3.9 3 0 0 3 3 3 3 WSC domain DUF4847 PF16139.5 ADV23630.1 - 0.049 13.5 0.0 20 5.1 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4847) CHCH PF06747.13 ADV23630.1 - 0.095 12.9 6.0 34 4.7 0.0 4.6 5 0 0 5 5 5 0 CHCH domain UTP25 PF06862.12 ADV23631.1 - 3.4e-176 586.7 0.1 4e-176 586.4 0.1 1.0 1 0 0 1 1 1 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 DEAD PF00270.29 ADV23631.1 - 0.064 13.0 0.0 6.1 6.6 0.0 2.5 2 0 0 2 2 2 0 DEAD/DEAH box helicase DUF4588 PF15251.6 ADV23631.1 - 0.31 10.8 1.9 3.9 7.2 0.1 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4588) RdRP PF05183.12 ADV23632.1 - 5.9e-142 474.3 0.0 8.1e-142 473.8 0.0 1.2 1 0 0 1 1 1 1 RNA dependent RNA polymerase ORC6 PF05460.13 ADV23634.1 - 0.3 10.3 1.0 0.35 10.1 1.0 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) TT_ORF2 PF02957.15 ADV23635.1 - 6 7.8 7.6 1.9 9.4 4.1 2.0 1 1 1 2 2 2 0 TT viral ORF2 tRNA-synt_1d PF00750.19 ADV23636.1 - 6.1e-91 305.0 2.5 8.5e-91 304.5 2.5 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 ADV23636.1 - 3.4e-18 66.0 0.0 9.6e-18 64.5 0.0 1.8 1 0 0 1 1 1 1 DALR anticodon binding domain DUF3889 PF13028.6 ADV23636.1 - 0.089 12.7 0.1 0.23 11.4 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3889) RWD PF05773.22 ADV23637.1 - 1.5e-14 54.3 0.2 2.6e-14 53.5 0.2 1.5 1 0 0 1 1 1 1 RWD domain DFRP_C PF16543.5 ADV23637.1 - 0.0001 22.7 4.4 0.0001 22.7 4.4 4.0 2 1 2 4 4 4 1 DRG Family Regulatory Proteins, Tma46 PheRS_DBD2 PF18554.1 ADV23637.1 - 0.16 12.0 1.1 0.34 10.9 1.1 1.6 1 0 0 1 1 1 0 PheRS DNA binding domain 2 CBP4 PF07960.11 ADV23637.1 - 3 7.7 12.2 0.62 9.9 7.2 2.0 2 0 0 2 2 2 0 CBP4 Adaptin_N PF01602.20 ADV23640.1 - 6e-129 431.0 2.0 8.1e-129 430.5 2.0 1.2 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptin_C PF02296.16 ADV23640.1 - 2.3e-38 130.9 0.0 6.1e-38 129.5 0.0 1.8 2 0 0 2 2 2 1 Alpha adaptin AP2, C-terminal domain Alpha_adaptinC2 PF02883.20 ADV23640.1 - 4.9e-17 62.2 0.0 1.1e-16 61.1 0.0 1.6 1 0 0 1 1 1 1 Adaptin C-terminal domain Cnd1 PF12717.7 ADV23640.1 - 4.3e-06 26.9 0.7 0.0025 17.9 0.0 3.7 1 1 3 4 4 4 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 ADV23640.1 - 0.012 16.0 2.7 8.2 6.9 0.1 4.7 3 2 1 4 4 4 0 HEAT repeats HEAT PF02985.22 ADV23640.1 - 0.012 15.8 0.2 0.97 9.9 0.0 3.9 4 0 0 4 4 4 0 HEAT repeat RTP1_C1 PF10363.9 ADV23640.1 - 0.058 13.6 1.3 0.22 11.7 0.5 2.3 2 1 1 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 RasGEF_N_2 PF14663.6 ADV23640.1 - 0.095 13.1 0.3 5.4 7.5 0.1 3.3 4 0 0 4 4 4 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain Cohesin_HEAT PF12765.7 ADV23640.1 - 0.22 11.8 1.3 6.7 7.1 0.1 3.0 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion Epimerase PF01370.21 ADV23641.1 - 4.9e-18 65.5 1.6 1.6e-10 40.9 0.2 2.4 2 1 1 3 3 3 2 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 ADV23641.1 - 2.2e-13 50.5 0.1 3.9e-13 49.7 0.0 1.5 2 0 0 2 2 2 1 NAD(P)H-binding NmrA PF05368.13 ADV23641.1 - 1e-11 44.9 1.2 2.5e-11 43.6 0.3 1.8 2 0 0 2 2 2 1 NmrA-like family GDP_Man_Dehyd PF16363.5 ADV23641.1 - 6.3e-09 35.7 0.4 7.2e-06 25.6 0.1 2.1 2 0 0 2 2 2 2 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 ADV23641.1 - 2.5e-08 33.3 0.1 3.9e-05 22.8 0.0 2.2 2 0 0 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 ADV23641.1 - 1e-07 31.4 0.5 0.00058 19.1 0.1 2.1 2 0 0 2 2 2 2 RmlD substrate binding domain TrkA_N PF02254.18 ADV23641.1 - 0.0014 18.8 0.1 0.0026 18.0 0.1 1.5 1 0 0 1 1 1 1 TrkA-N domain NAD_binding_4 PF07993.12 ADV23641.1 - 0.0055 15.9 0.3 0.35 10.0 0.1 2.4 2 1 0 2 2 2 1 Male sterility protein UDPG_MGDP_dh_N PF03721.14 ADV23641.1 - 0.082 12.5 0.1 0.13 11.9 0.1 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Epimerase PF01370.21 ADV23642.1 - 5.9e-17 61.9 0.5 5.9e-11 42.3 0.4 2.1 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 ADV23642.1 - 4.5e-13 49.5 0.5 6.7e-13 48.9 0.5 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 ADV23642.1 - 1.1e-12 48.1 0.4 7.9e-12 45.2 0.3 1.9 2 0 0 2 2 2 1 NmrA-like family GDP_Man_Dehyd PF16363.5 ADV23642.1 - 8e-06 25.5 2.1 2.1e-05 24.1 0.2 2.2 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 ADV23642.1 - 1.9e-05 23.8 0.0 0.00012 21.2 0.0 1.9 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 ADV23642.1 - 3.1e-05 23.2 0.1 0.0038 16.4 0.2 2.0 2 0 0 2 2 2 2 RmlD substrate binding domain TrkA_N PF02254.18 ADV23642.1 - 4.9e-05 23.6 0.2 0.00011 22.4 0.2 1.5 1 0 0 1 1 1 1 TrkA-N domain Sacchrp_dh_NADP PF03435.18 ADV23642.1 - 0.0006 20.1 0.1 0.0011 19.3 0.1 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain ApbA PF02558.16 ADV23642.1 - 0.013 15.2 0.1 0.028 14.1 0.1 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA DFP PF04127.15 ADV23642.1 - 0.015 15.1 0.4 0.023 14.5 0.4 1.2 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein NAD_binding_4 PF07993.12 ADV23642.1 - 0.028 13.6 0.2 0.83 8.8 0.2 2.3 2 1 0 2 2 2 0 Male sterility protein adh_short PF00106.25 ADV23642.1 - 0.044 13.2 0.6 0.069 12.6 0.6 1.3 1 0 0 1 1 1 0 short chain dehydrogenase DapB_N PF01113.20 ADV23642.1 - 0.075 13.2 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus JHD PF17811.1 ADV23643.1 - 8.8e-09 35.8 0.0 2e-08 34.7 0.0 1.7 1 0 0 1 1 1 1 Jumonji helical domain JmjC PF02373.22 ADV23643.1 - 0.0083 16.5 0.4 0.02 15.3 0.4 1.7 1 0 0 1 1 1 1 JmjC domain, hydroxylase PHD PF00628.29 ADV23643.1 - 0.052 13.4 9.9 0.12 12.3 6.8 2.9 2 1 0 2 2 2 0 PHD-finger Cupin_8 PF13621.6 ADV23643.1 - 0.062 13.0 0.1 0.2 11.3 0.0 1.7 1 1 1 2 2 2 0 Cupin-like domain PHD_4 PF16866.5 ADV23643.1 - 0.092 12.9 0.6 0.23 11.5 0.6 1.7 1 0 0 1 1 1 0 PHD-finger Cupin_2 PF07883.11 ADV23643.1 - 0.1 12.4 0.0 0.22 11.3 0.0 1.5 1 0 0 1 1 1 0 Cupin domain Cupin_1 PF00190.22 ADV23643.1 - 0.12 11.9 0.0 0.36 10.4 0.0 1.6 1 1 0 1 1 1 0 Cupin PI3_PI4_kinase PF00454.27 ADV23645.1 - 5.8e-34 118.0 0.0 2.1e-32 112.9 0.0 2.2 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 ADV23645.1 - 3.1e-06 26.7 0.0 6.6e-06 25.6 0.0 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF4135 PF13575.6 ADV23645.1 - 0.027 13.8 0.0 0.051 12.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) ADH_zinc_N PF00107.26 ADV23646.1 - 4.6e-28 97.8 2.6 1.8e-27 95.9 2.0 2.0 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ADV23646.1 - 7.8e-28 96.5 0.4 1.3e-27 95.8 0.4 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 ADV23646.1 - 4.4e-09 37.5 0.4 8.9e-09 36.5 0.4 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase DDE_1 PF03184.19 ADV23647.1 - 1.2e-10 41.3 0.0 3.4e-10 39.9 0.0 1.6 1 1 1 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 ADV23647.1 - 0.024 14.7 0.3 0.11 12.6 0.0 2.3 2 0 0 2 2 2 0 Tc5 transposase DNA-binding domain DDE_3 PF13358.6 ADV23647.1 - 0.027 14.2 0.0 0.11 12.2 0.0 2.0 2 0 0 2 2 2 0 DDE superfamily endonuclease SprT-like PF10263.9 ADV23648.1 - 5.4e-29 100.3 0.2 1.1e-28 99.3 0.2 1.6 1 0 0 1 1 1 1 SprT-like family Zn_ribbon_SprT PF17283.2 ADV23648.1 - 8.4e-05 22.4 4.0 0.00014 21.7 4.0 1.4 1 0 0 1 1 1 1 SprT-like zinc ribbon domain HMG_box PF00505.19 ADV23648.1 - 0.0002 21.7 0.3 0.00042 20.7 0.3 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box YABBY PF04690.13 ADV23648.1 - 0.0097 16.5 0.1 0.026 15.1 0.1 1.7 1 0 0 1 1 1 1 YABBY protein DTHCT PF08070.11 ADV23648.1 - 0.016 15.9 0.2 0.016 15.9 0.2 3.5 3 1 0 3 3 3 0 DTHCT (NUC029) region Zn-ribbon_8 PF09723.10 ADV23648.1 - 0.079 13.1 1.4 0.19 11.8 1.4 1.6 1 0 0 1 1 1 0 Zinc ribbon domain DUF3399 PF11879.8 ADV23648.1 - 0.084 13.2 0.5 0.084 13.2 0.5 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3399) DUF4379 PF14311.6 ADV23648.1 - 3.6 8.0 7.5 0.91 9.9 3.9 2.0 2 0 0 2 2 2 0 Probable Zinc-ribbon domain Pheromone PF08015.11 ADV23648.1 - 4.2 8.5 7.6 2.2 9.4 4.3 2.3 2 0 0 2 2 2 0 Fungal mating-type pheromone zf-RING_2 PF13639.6 ADV23649.1 - 2.9e-11 43.5 7.4 4.7e-11 42.8 7.4 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 ADV23649.1 - 2.7e-07 30.8 8.9 5.1e-07 29.9 8.9 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 ADV23649.1 - 1.4e-06 27.9 3.7 2.8e-06 27.0 3.7 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 ADV23649.1 - 2.2e-06 27.4 6.6 3.6e-06 26.7 6.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ADV23649.1 - 4.8e-06 26.3 5.8 8.1e-06 25.6 5.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ADV23649.1 - 8.2e-06 25.7 6.2 1.3e-05 25.0 6.2 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 ADV23649.1 - 0.00014 21.6 4.8 0.00022 21.0 4.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 ADV23649.1 - 0.0002 21.3 4.5 0.00051 20.1 4.5 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 ADV23649.1 - 0.0026 17.6 5.7 0.0053 16.6 5.7 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 ADV23649.1 - 0.011 15.7 4.6 0.024 14.7 4.6 1.5 1 0 0 1 1 1 0 RING-type zinc-finger RINGv PF12906.7 ADV23649.1 - 0.037 14.2 7.1 0.066 13.3 7.1 1.4 1 0 0 1 1 1 0 RING-variant domain Zn_ribbon_17 PF17120.5 ADV23649.1 - 0.039 13.6 6.4 0.078 12.6 6.4 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type FTA4 PF13093.6 ADV23649.1 - 0.053 13.4 1.0 0.17 11.8 1.0 1.9 1 0 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 AATF-Che1 PF13339.6 ADV23649.1 - 0.11 13.2 0.9 0.55 10.9 0.9 2.2 1 0 0 1 1 1 0 Apoptosis antagonizing transcription factor zf-RING_4 PF14570.6 ADV23649.1 - 0.38 10.6 6.2 0.82 9.5 6.2 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4_5 PF17121.5 ADV23649.1 - 0.64 9.9 3.7 0.81 9.6 3.0 1.6 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING-like PF08746.11 ADV23649.1 - 1.8 8.9 10.7 3.2 8.1 10.7 1.4 1 0 0 1 1 1 0 RING-like domain FANCL_C PF11793.8 ADV23649.1 - 2.2 8.5 5.7 4.4 7.6 5.7 1.4 1 0 0 1 1 1 0 FANCL C-terminal domain NADH-u_ox-rdase PF10785.9 ADV23650.1 - 2.7e-32 111.3 0.1 3.8e-32 110.8 0.1 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit NADH_u_ox_C PF12853.7 ADV23650.1 - 3e-21 75.2 0.1 4.3e-21 74.7 0.1 1.2 1 0 0 1 1 1 1 C-terminal of NADH-ubiquinone oxidoreductase 21 kDa subunit BHD_2 PF10404.9 ADV23650.1 - 0.093 13.7 0.1 0.18 12.8 0.1 1.4 1 0 0 1 1 1 0 Rad4 beta-hairpin domain 2 zf-HIT PF04438.16 ADV23652.1 - 0.00016 21.5 8.7 0.00025 20.9 8.7 1.3 1 0 0 1 1 1 1 HIT zinc finger NRDD PF13597.6 ADV23652.1 - 0.37 9.5 3.6 0.47 9.2 3.6 1.1 1 0 0 1 1 1 0 Anaerobic ribonucleoside-triphosphate reductase Apolipoprotein PF01442.18 ADV23653.1 - 3.3 7.5 27.3 2.5 7.9 1.8 5.2 2 2 0 3 3 3 0 Apolipoprotein A1/A4/E domain Coatomer_WDAD PF04053.14 ADV23654.1 - 4.5e-147 490.7 0.0 9.1e-147 489.7 0.0 1.5 1 0 0 1 1 1 1 Coatomer WD associated region COPI_C PF06957.11 ADV23654.1 - 2.9e-115 385.3 0.1 3.7e-115 384.9 0.1 1.1 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus WD40 PF00400.32 ADV23654.1 - 7.4e-42 140.5 11.8 1.1e-08 35.5 0.1 7.9 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV23654.1 - 3.5e-13 49.7 0.0 0.0014 18.9 0.0 5.4 3 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain TPR_1 PF00515.28 ADV23654.1 - 0.0053 16.5 0.0 5.4 7.0 0.0 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat Nucleoporin_N PF08801.11 ADV23654.1 - 0.084 11.6 0.2 7.8 5.1 0.0 3.1 3 1 0 3 3 3 0 Nup133 N terminal like eIF2A PF08662.11 ADV23654.1 - 0.17 11.8 0.3 2.3 8.0 0.0 2.6 3 0 0 3 3 3 0 Eukaryotic translation initiation factor eIF2A TPR_2 PF07719.17 ADV23654.1 - 0.19 11.9 2.5 12 6.3 0.0 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 ADV23654.1 - 0.9 10.5 9.2 2.1 9.4 0.1 4.9 4 1 1 5 5 5 0 Tetratricopeptide repeat Nup160 PF11715.8 ADV23654.1 - 6.7 5.2 8.7 8.9 4.8 0.2 3.8 2 1 2 4 4 4 0 Nucleoporin Nup120/160 FMO-like PF00743.19 ADV23655.1 - 8.6e-28 97.0 0.0 1.9e-20 72.8 0.0 2.6 2 1 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 ADV23655.1 - 2.3e-09 36.9 0.0 2.1e-05 23.9 0.0 2.9 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 ADV23655.1 - 2.1e-08 33.7 0.0 6e-07 28.9 0.0 2.1 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 ADV23655.1 - 8.3e-08 31.8 0.0 3.1e-07 29.9 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ADV23656.1 - 1.9e-27 96.8 0.2 2.4e-27 96.5 0.2 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 ADV23656.1 - 0.00049 20.6 0.2 0.0025 18.4 0.2 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 ADV23656.1 - 0.0016 17.6 0.5 0.0027 16.9 0.5 1.3 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 ADV23656.1 - 0.0019 17.5 0.7 0.0028 16.9 0.1 1.6 2 0 0 2 2 2 1 Thi4 family Pyr_redox_2 PF07992.14 ADV23656.1 - 0.0057 15.9 0.7 0.013 14.8 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ADV23656.1 - 0.02 15.1 0.2 0.048 13.9 0.2 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 ADV23656.1 - 0.02 14.2 0.1 0.035 13.4 0.1 1.4 1 0 0 1 1 1 0 FAD binding domain 3HCDH_N PF02737.18 ADV23656.1 - 0.048 13.5 0.1 0.072 13.0 0.1 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Lycopene_cycl PF05834.12 ADV23656.1 - 0.068 12.2 0.3 0.14 11.2 0.3 1.5 1 0 0 1 1 1 0 Lycopene cyclase protein Abhydrolase_3 PF07859.13 ADV23657.1 - 1e-43 149.7 0.0 1.3e-43 149.3 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 ADV23657.1 - 1.7e-07 30.5 0.0 7.5e-07 28.4 0.0 1.7 1 1 0 1 1 1 1 Carboxylesterase family Peptidase_S9 PF00326.21 ADV23657.1 - 0.0041 16.6 0.0 0.65 9.4 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family E1-E2_ATPase PF00122.20 ADV23658.1 - 1.2e-38 132.4 0.2 9.2e-38 129.6 0.1 2.5 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 ADV23658.1 - 5.1e-20 72.7 0.2 1.5e-19 71.1 0.2 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 ADV23658.1 - 1.4e-10 40.7 0.0 4.6e-10 39.0 0.0 1.9 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 ADV23658.1 - 0.00016 21.5 0.0 0.0085 15.9 0.1 2.6 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 ADV23658.1 - 0.021 15.2 0.0 0.047 14.1 0.0 1.6 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ADV23658.1 - 0.039 14.0 0.1 0.54 10.4 0.0 2.6 3 0 0 3 3 3 0 Cation transport ATPase (P-type) Pkinase PF00069.25 ADV23660.1 - 5.2e-64 216.2 0.1 4.9e-43 147.4 0.1 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ADV23660.1 - 3.1e-26 92.2 0.3 2.8e-20 72.7 0.1 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 ADV23660.1 - 3.9e-07 29.3 0.1 5.6e-07 28.8 0.1 1.1 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 ADV23660.1 - 0.0014 18.6 0.3 0.48 10.3 0.1 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 ADV23660.1 - 0.0082 15.5 0.0 0.017 14.5 0.0 1.5 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 ADV23660.1 - 0.065 12.3 0.0 0.1 11.6 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Kinase-like PF14531.6 ADV23660.1 - 0.083 12.2 0.0 0.18 11.1 0.0 1.6 1 1 0 1 1 1 0 Kinase-like Pkinase_fungal PF17667.1 ADV23660.1 - 0.1 11.4 0.2 0.17 10.6 0.0 1.4 2 0 0 2 2 2 0 Fungal protein kinase Pox_ser-thr_kin PF05445.11 ADV23660.1 - 0.12 11.4 0.1 0.18 10.7 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Pkinase_C PF00433.24 ADV23660.1 - 0.15 12.8 0.1 0.32 11.8 0.1 1.6 1 0 0 1 1 1 0 Protein kinase C terminal domain Bac_rhodopsin PF01036.18 ADV23661.1 - 5.3e-28 98.1 13.6 6.6e-28 97.8 13.6 1.1 1 0 0 1 1 1 1 Bacteriorhodopsin-like protein RCR PF12273.8 ADV23661.1 - 0.52 11.0 4.5 3 8.5 0.1 2.4 2 0 0 2 2 2 0 Chitin synthesis regulation, resistance to Congo red DUF4131 PF13567.6 ADV23661.1 - 1.4 8.5 10.6 2.4 7.8 2.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) FAD_binding_3 PF01494.19 ADV23662.1 - 1.3e-19 70.7 0.0 3.2e-19 69.4 0.0 1.6 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 ADV23662.1 - 5.4e-05 23.3 0.1 0.0003 21.0 0.1 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 ADV23662.1 - 0.006 15.9 0.0 0.03 13.6 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase SE PF08491.10 ADV23662.1 - 0.0061 15.6 0.0 0.75 8.8 0.0 2.2 2 0 0 2 2 2 2 Squalene epoxidase Lycopene_cycl PF05834.12 ADV23662.1 - 0.032 13.3 0.0 4.5 6.2 0.0 2.4 3 0 0 3 3 3 0 Lycopene cyclase protein DAO PF01266.24 ADV23662.1 - 0.032 13.8 0.1 0.071 12.7 0.1 1.5 1 0 0 1 1 1 0 FAD dependent oxidoreductase Caleosin PF05042.13 ADV23662.1 - 0.038 13.9 0.6 0.065 13.2 0.6 1.3 1 0 0 1 1 1 0 Caleosin related protein Pyr_redox PF00070.27 ADV23662.1 - 0.092 13.3 0.0 0.35 11.5 0.0 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 ADV23662.1 - 0.11 11.6 0.1 0.16 11.0 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain GIDA PF01134.22 ADV23662.1 - 0.22 10.6 0.1 0.32 10.0 0.1 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A ACOX PF01756.19 ADV23663.1 - 6.1e-52 175.8 0.1 9.3e-52 175.2 0.1 1.3 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_dh_M PF02770.19 ADV23663.1 - 3.6e-19 68.8 0.2 8e-19 67.6 0.2 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 ADV23663.1 - 3.9e-10 40.1 0.6 1.2e-09 38.6 0.0 2.1 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_ox_N PF14749.6 ADV23663.1 - 2.5e-09 37.8 0.0 1e-08 35.7 0.0 2.1 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_2 PF08028.11 ADV23663.1 - 0.039 14.2 0.0 0.12 12.6 0.0 1.9 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, C-terminal domain adh_short PF00106.25 ADV23665.1 - 1.3e-29 103.1 0.0 1.8e-29 102.6 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ADV23665.1 - 2.2e-18 66.7 0.0 2.8e-18 66.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ADV23665.1 - 1.2e-14 54.6 0.1 4.3e-14 52.8 0.0 1.8 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 ADV23665.1 - 4.9e-07 29.5 0.0 5.1e-06 26.1 0.0 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 ADV23665.1 - 0.00019 21.4 0.0 0.00029 20.8 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding THF_DHG_CYH_C PF02882.19 ADV23665.1 - 0.00055 19.3 0.0 0.0011 18.3 0.0 1.4 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain F420_oxidored PF03807.17 ADV23665.1 - 0.0033 18.0 0.1 0.0066 17.0 0.1 1.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_7 PF13241.6 ADV23665.1 - 0.0047 17.4 0.1 0.009 16.4 0.1 1.6 1 1 0 1 1 1 1 Putative NAD(P)-binding DFP PF04127.15 ADV23665.1 - 0.048 13.5 0.3 0.095 12.5 0.3 1.5 1 1 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein Shikimate_DH PF01488.20 ADV23665.1 - 0.05 13.7 0.0 0.083 13.0 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Glyco_tran_WecB PF03808.13 ADV23665.1 - 0.051 13.5 0.0 0.12 12.3 0.0 1.7 1 1 0 1 1 1 0 Glycosyl transferase WecB/TagA/CpsF family GDP_Man_Dehyd PF16363.5 ADV23665.1 - 0.054 12.9 0.0 0.075 12.4 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Sacchrp_dh_NADP PF03435.18 ADV23665.1 - 0.094 13.0 0.2 0.19 12.0 0.2 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain PALP PF00291.25 ADV23665.1 - 0.12 11.7 0.3 0.52 9.7 0.4 1.8 1 1 1 2 2 2 0 Pyridoxal-phosphate dependent enzyme NAD_binding_2 PF03446.15 ADV23665.1 - 0.13 12.4 0.0 0.22 11.7 0.0 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase GARS_N PF02844.15 ADV23665.1 - 0.14 12.9 0.0 0.39 11.5 0.0 1.7 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, N domain RmlD_sub_bind PF04321.17 ADV23665.1 - 0.17 11.0 0.0 0.23 10.6 0.0 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain BRO1 PF03097.18 ADV23666.1 - 1.7e-104 349.8 0.0 2.3e-104 349.3 0.0 1.2 1 0 0 1 1 1 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 ADV23666.1 - 4.4e-69 233.0 0.4 7.4e-69 232.3 0.4 1.4 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV DUF3510 PF12022.8 ADV23666.1 - 0.033 14.6 0.2 0.13 12.7 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3510) CAP_N PF01213.19 ADV23666.1 - 0.091 12.2 0.1 0.091 12.2 0.1 3.5 1 1 1 3 3 3 0 Adenylate cyclase associated (CAP) N terminal FadA PF09403.10 ADV23666.1 - 2.2 8.8 7.6 0.28 11.7 0.4 2.9 2 1 0 2 2 2 0 Adhesion protein FadA WD40 PF00400.32 ADV23667.1 - 6.6e-34 115.4 8.7 4.9e-05 24.0 0.0 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV23667.1 - 1.4e-15 57.4 0.0 0.00037 20.7 0.0 5.4 3 3 2 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ADV23667.1 - 0.0001 21.8 0.0 0.6 9.4 0.0 3.0 3 0 0 3 3 3 2 WD40-like domain PQQ_2 PF13360.6 ADV23667.1 - 0.00039 20.1 0.1 0.28 10.7 0.0 2.9 2 1 1 3 3 3 2 PQQ-like domain Ge1_WD40 PF16529.5 ADV23667.1 - 0.072 12.0 0.0 2.3 7.1 0.0 2.5 2 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ADV23667.1 - 0.078 12.9 0.0 0.56 10.1 0.0 2.2 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A PQQ PF01011.21 ADV23667.1 - 0.13 12.3 0.5 2.4 8.2 0.0 3.2 3 0 0 3 3 3 0 PQQ enzyme repeat JmjC PF02373.22 ADV23668.1 - 1.3e-10 41.7 0.1 3e-10 40.5 0.1 1.6 1 0 0 1 1 1 1 JmjC domain, hydroxylase Cupin_8 PF13621.6 ADV23668.1 - 2.4e-06 27.4 0.0 3.2e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 Cupin-like domain DUF1738 PF08401.11 ADV23668.1 - 0.051 13.7 1.1 0.08 13.1 1.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1738) DUF5415 PF17436.2 ADV23668.1 - 0.19 11.8 1.2 0.57 10.3 0.3 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5415) DUF2418 PF10332.9 ADV23669.1 - 2.5e-22 79.2 1.5 3.6e-22 78.7 0.2 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2418) Internalin_N PF12354.8 ADV23669.1 - 0.061 13.4 0.2 0.061 13.4 0.2 2.3 2 0 0 2 2 2 0 Bacterial adhesion/invasion protein N terminal GDI PF00996.18 ADV23670.1 - 3.4e-211 701.4 0.0 3.9e-211 701.2 0.0 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor adh_short_C2 PF13561.6 ADV23671.1 - 2.8e-05 23.8 0.3 3.3e-05 23.6 0.3 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ADV23671.1 - 0.0067 15.9 0.1 0.0076 15.7 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase NAD_binding_8 PF13450.6 ADV23672.1 - 1.2e-08 35.1 0.3 3.1e-08 33.7 0.3 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 ADV23672.1 - 7.4e-08 32.1 0.0 2.1e-07 30.6 0.0 1.6 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase Pyr_redox_3 PF13738.6 ADV23672.1 - 0.005 16.1 0.2 0.0073 15.6 0.2 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 ADV23672.1 - 0.025 13.8 0.1 0.041 13.1 0.1 1.3 1 0 0 1 1 1 0 FAD binding domain FAD_oxidored PF12831.7 ADV23672.1 - 0.032 13.6 0.0 0.046 13.1 0.0 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ADV23672.1 - 0.039 13.2 0.0 0.086 12.1 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 ADV23672.1 - 0.051 12.3 0.1 0.072 11.8 0.1 1.2 1 0 0 1 1 1 0 HI0933-like protein Thi4 PF01946.17 ADV23672.1 - 0.054 12.7 0.1 0.098 11.9 0.1 1.3 1 0 0 1 1 1 0 Thi4 family NAD_binding_9 PF13454.6 ADV23672.1 - 0.078 13.0 0.1 0.17 11.9 0.1 1.6 1 0 0 1 1 1 0 FAD-NAD(P)-binding DAO PF01266.24 ADV23672.1 - 0.1 12.1 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase Acid_PPase PF12689.7 ADV23673.1 - 2.4e-36 125.1 0.0 4.4e-36 124.3 0.0 1.3 1 1 0 1 1 1 1 Acid Phosphatase His_Phos_2 PF00328.22 ADV23674.1 - 1.3e-35 123.5 0.0 1.9e-35 123.0 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) PDEase_I_N PF08499.12 ADV23674.1 - 0.095 12.6 0.6 0.34 10.8 0.1 2.1 2 0 0 2 2 2 0 3'5'-cyclic nucleotide phosphodiesterase N-terminal PhoD PF09423.10 ADV23675.1 - 9.3e-16 57.8 0.0 1.2e-15 57.4 0.0 1.1 1 0 0 1 1 1 1 PhoD-like phosphatase PhoD_N PF16655.5 ADV23675.1 - 0.0041 17.6 0.1 0.0085 16.6 0.1 1.5 1 0 0 1 1 1 1 PhoD-like phosphatase, N-terminal domain Pur_ac_phosph_N PF16656.5 ADV23675.1 - 0.026 15.1 0.3 0.053 14.1 0.3 1.5 1 0 0 1 1 1 0 Purple acid Phosphatase, N-terminal domain Glyco_transf_90 PF05686.12 ADV23676.1 - 4.9e-24 85.0 0.6 8.4e-24 84.2 0.6 1.3 1 1 0 1 1 1 1 Glycosyl transferase family 90 DUF5483 PF17581.2 ADV23676.1 - 0.073 12.0 0.1 0.1 11.4 0.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5483) DUF3431 PF11913.8 ADV23677.1 - 4.8e-05 23.2 0.1 5.8e-05 23.0 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3431) NOG1 PF06858.14 ADV23677.1 - 0.091 12.6 0.1 0.21 11.4 0.0 1.6 2 0 0 2 2 2 0 Nucleolar GTP-binding protein 1 (NOG1) Ferric_reduct PF01794.19 ADV23679.1 - 5.4e-21 75.0 13.8 5.4e-21 75.0 13.8 2.8 2 1 1 3 3 3 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 ADV23679.1 - 7.4e-21 74.9 0.0 1.3e-20 74.1 0.0 1.4 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 ADV23679.1 - 1.1e-13 51.2 0.0 2.8e-13 49.9 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_1 PF00175.21 ADV23679.1 - 0.0022 18.6 0.0 0.67 10.6 0.0 2.5 2 0 0 2 2 2 2 Oxidoreductase NAD-binding domain MFS_1 PF07690.16 ADV23680.1 - 9.7e-17 60.9 63.3 1.2e-10 40.9 32.1 3.2 2 1 0 3 3 3 2 Major Facilitator Superfamily TRI12 PF06609.13 ADV23680.1 - 0.0001 20.9 15.7 0.0001 20.9 15.7 1.9 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Pox_A14 PF05767.12 ADV23680.1 - 5.2 7.3 10.2 0.26 11.5 1.2 3.1 3 0 0 3 3 3 0 Poxvirus virion envelope protein A14 Phos_pyr_kin PF08543.12 ADV23681.1 - 7.5e-73 244.9 1.3 1.6e-71 240.5 1.3 2.1 1 1 0 1 1 1 1 Phosphomethylpyrimidine kinase TENA_THI-4 PF03070.16 ADV23681.1 - 1.3e-46 159.0 0.0 2.6e-46 158.1 0.0 1.4 1 0 0 1 1 1 1 TENA/THI-4/PQQC family PfkB PF00294.24 ADV23681.1 - 0.00015 21.2 0.0 0.00025 20.5 0.0 1.3 1 0 0 1 1 1 1 pfkB family carbohydrate kinase HK PF02110.15 ADV23681.1 - 0.0011 18.4 1.0 1.2 8.5 0.0 2.3 2 1 0 2 2 2 2 Hydroxyethylthiazole kinase family CK_II_beta PF01214.18 ADV23682.1 - 2.3e-74 249.1 0.0 2.9e-74 248.8 0.0 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit YL1 PF05764.13 ADV23682.1 - 1.4 9.0 10.5 2 8.5 10.5 1.2 1 0 0 1 1 1 0 YL1 nuclear protein NOA36 PF06524.12 ADV23682.1 - 1.7 7.9 6.2 2.5 7.3 6.2 1.2 1 0 0 1 1 1 0 NOA36 protein Nop14 PF04147.12 ADV23682.1 - 9.8 4.2 8.5 12 3.9 8.5 1.1 1 0 0 1 1 1 0 Nop14-like family Fer2 PF00111.27 ADV23683.1 - 2.1e-10 40.4 0.2 3.1e-10 39.9 0.2 1.2 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain AMP-binding PF00501.28 ADV23684.1 - 1.9e-71 240.9 0.0 3.2e-71 240.2 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.12 ADV23684.1 - 1.2e-68 231.1 0.0 1.8e-68 230.5 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein PP-binding PF00550.25 ADV23684.1 - 6e-11 42.5 0.0 1.5e-10 41.3 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site Epimerase PF01370.21 ADV23684.1 - 1.3e-10 41.2 0.0 2.2e-10 40.4 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ADV23684.1 - 2.2e-06 26.9 0.0 4.3e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family AMP-binding_C PF13193.6 ADV23684.1 - 0.00093 20.1 0.1 0.006 17.5 0.1 2.5 1 1 0 1 1 1 1 AMP-binding enzyme C-terminal domain NAD_binding_10 PF13460.6 ADV23684.1 - 0.00099 19.0 0.2 0.0045 16.9 0.2 2.1 1 1 0 1 1 1 1 NAD(P)H-binding Condensation PF00668.20 ADV23684.1 - 0.0059 15.3 0.0 0.046 12.4 0.0 2.2 1 1 0 1 1 1 1 Condensation domain KR PF08659.10 ADV23684.1 - 0.016 15.2 0.0 0.04 13.8 0.0 1.6 1 0 0 1 1 1 0 KR domain Polysacc_synt_2 PF02719.15 ADV23684.1 - 0.04 13.0 0.0 0.11 11.6 0.0 1.7 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein RIC1 PF07064.13 ADV23685.1 - 2.8e-86 289.0 0.2 3.9e-86 288.5 0.2 1.2 1 0 0 1 1 1 1 RIC1 ANAPC4_WD40 PF12894.7 ADV23685.1 - 0.014 15.7 0.0 0.61 10.4 0.0 3.7 4 1 1 5 5 5 0 Anaphase-promoting complex subunit 4 WD40 domain Kelch_6 PF13964.6 ADV23685.1 - 0.11 12.8 0.0 0.56 10.6 0.0 2.2 2 0 0 2 2 2 0 Kelch motif MOZ_SAS PF01853.18 ADV23686.1 - 2.3e-71 239.2 0.0 3.6e-71 238.5 0.0 1.3 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 ADV23686.1 - 6.9e-20 70.4 0.7 6.9e-20 70.4 0.7 2.0 2 0 0 2 2 2 1 MYST family zinc finger domain PHD PF00628.29 ADV23686.1 - 7.1e-17 61.0 23.8 2.1e-09 37.1 7.0 3.3 2 1 1 3 3 3 2 PHD-finger PHD_4 PF16866.5 ADV23686.1 - 0.00078 19.5 19.3 0.024 14.7 8.2 2.7 1 1 1 2 2 2 1 PHD-finger C1_1 PF00130.22 ADV23686.1 - 0.18 11.7 16.1 0.05 13.5 0.9 2.9 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Zf_RING PF16744.5 ADV23686.1 - 4.5 7.5 12.6 19 5.5 5.1 2.8 1 1 1 2 2 2 0 KIAA1045 RING finger Methyltransf_11 PF08241.12 ADV23687.1 - 3.7e-06 27.5 0.0 7.8e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ADV23687.1 - 1.8e-05 24.7 0.0 4.3e-05 23.4 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 ADV23687.1 - 2.1e-05 25.1 0.1 6e-05 23.7 0.1 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ADV23687.1 - 0.00014 22.5 0.0 0.0003 21.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Trypan_PARP PF05887.11 ADV23687.1 - 0.24 11.4 8.6 0.036 14.0 3.2 2.3 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) Ribosomal_60s PF00428.19 ADV23688.1 - 4.8e-23 81.6 9.4 9.1e-23 80.7 7.4 2.1 2 0 0 2 2 2 1 60s Acidic ribosomal protein Ribosomal_L10 PF00466.20 ADV23688.1 - 2.4e-22 78.9 0.4 2.2e-21 75.8 0.1 2.1 2 0 0 2 2 2 1 Ribosomal protein L10 RL10P_insert PF17777.1 ADV23688.1 - 3.4e-22 78.2 0.0 9.1e-22 76.9 0.0 1.8 2 0 0 2 2 2 1 Insertion domain in 60S ribosomal protein L10P Peripla_BP_7 PF18610.1 ADV23688.1 - 0.14 12.3 0.1 4 7.6 0.0 2.9 4 0 0 4 4 4 0 Periplasmic binding protein domain tRNA-synt_2 PF00152.20 ADV23689.1 - 2.7e-74 250.1 0.0 5e-74 249.2 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) DUF2156 PF09924.9 ADV23689.1 - 1.1e-05 24.7 0.1 0.00086 18.4 0.0 2.3 2 0 0 2 2 2 2 Uncharacterised conserved protein (DUF2156) tRNA_anti-codon PF01336.25 ADV23689.1 - 0.0048 16.8 0.0 0.0099 15.8 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 ADV23689.1 - 0.0091 15.5 0.2 3 7.3 0.1 2.5 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) CEP19 PF14933.6 ADV23689.1 - 0.029 14.7 5.1 0.098 13.0 5.1 1.8 1 0 0 1 1 1 0 CEP19-like protein Fungal_trans PF04082.18 ADV23690.1 - 1.9e-07 30.4 0.9 1.9e-07 30.4 0.9 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ADV23690.1 - 7e-07 29.3 10.6 1.4e-06 28.3 10.6 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 ADV23691.1 - 2.6e-32 112.1 33.8 2.6e-32 112.1 33.8 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_4 PF06779.14 ADV23691.1 - 7.7e-06 25.4 1.1 7.7e-06 25.4 1.1 2.1 2 1 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB Phage_holin_2_4 PF16082.5 ADV23691.1 - 0.2 11.4 5.4 15 5.4 1.8 3.7 4 0 0 4 4 4 0 Bacteriophage holin family, superfamily II-like SHR3_chaperone PF08229.11 ADV23691.1 - 4.3 6.3 5.2 1.3 7.9 0.4 2.3 2 0 0 2 2 2 0 ER membrane protein SH3 TFIIA_gamma_N PF02268.16 ADV23692.1 - 8.9e-24 83.3 0.0 1.3e-23 82.7 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit, helical domain TFIIA_gamma_C PF02751.14 ADV23692.1 - 4.2e-21 74.8 0.0 6e-21 74.3 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit CdvA PF18822.1 ADV23692.1 - 0.045 13.6 0.0 0.061 13.1 0.0 1.1 1 0 0 1 1 1 0 CdvA-like coiled-coil domain adh_short PF00106.25 ADV23693.1 - 1.2e-23 83.6 0.1 1.9e-23 83.0 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ADV23693.1 - 1.5e-18 67.2 0.0 2.4e-18 66.5 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.10 ADV23693.1 - 7e-08 32.2 0.0 9.3e-08 31.8 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) CdiA_C PF18451.1 ADV23693.1 - 0.0033 17.6 0.7 0.0066 16.6 0.7 1.5 1 0 0 1 1 1 1 Contact-dependent growth inhibition CdiA C-terminal domain SPX PF03105.19 ADV23694.1 - 9.2e-50 170.7 0.0 2.1e-49 169.5 0.0 1.6 1 1 0 1 1 1 1 SPX domain zf-C3HC4_3 PF13920.6 ADV23694.1 - 5.2e-08 32.6 4.9 9.7e-08 31.8 4.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ADV23694.1 - 4.9e-07 29.5 6.8 9.4e-07 28.6 6.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 ADV23694.1 - 6.6e-07 29.4 6.9 1.5e-06 28.3 6.9 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 ADV23694.1 - 1.4e-06 28.0 6.8 2.7e-06 27.1 6.8 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 ADV23694.1 - 4.3e-06 27.0 6.6 8.4e-06 26.0 6.6 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 ADV23694.1 - 3.4e-05 23.6 7.5 6.3e-05 22.7 7.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ADV23694.1 - 0.00012 21.9 6.9 0.00026 20.9 6.9 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_4 PF14570.6 ADV23694.1 - 0.00018 21.3 1.4 0.00041 20.1 1.4 1.6 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-RING_UBOX PF13445.6 ADV23694.1 - 0.00029 20.8 5.0 0.00065 19.7 5.0 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.7 ADV23694.1 - 0.0093 16.2 3.0 0.024 14.9 3.0 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 ADV23694.1 - 0.17 12.0 2.1 0.27 11.3 0.9 1.9 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.6 ADV23694.1 - 0.27 11.1 4.4 0.55 10.1 4.4 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_10 PF16685.5 ADV23694.1 - 0.4 10.8 5.6 0.88 9.8 5.6 1.6 1 0 0 1 1 1 0 zinc RING finger of MSL2 Arginase PF00491.21 ADV23696.1 - 3.9e-75 252.9 0.0 4.8e-75 252.6 0.0 1.1 1 0 0 1 1 1 1 Arginase family SpoIIE PF07228.12 ADV23697.1 - 1.3e-10 41.6 0.0 3.6e-10 40.1 0.0 1.7 2 0 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 ADV23697.1 - 1.2e-08 34.8 0.0 2e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C GatB_N PF02934.15 ADV23698.1 - 8e-102 340.3 0.0 1e-101 340.0 0.0 1.1 1 0 0 1 1 1 1 GatB/GatE catalytic domain GatB_Yqey PF02637.18 ADV23698.1 - 2.9e-28 98.6 0.2 4.4e-28 98.0 0.2 1.3 1 0 0 1 1 1 1 GatB domain FTHFS PF01268.19 ADV23699.1 - 2.5e-260 864.4 0.2 3.5e-260 863.9 0.2 1.2 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase THF_DHG_CYH_C PF02882.19 ADV23699.1 - 4.4e-66 221.1 1.1 5.9e-66 220.7 0.1 1.8 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 ADV23699.1 - 2.3e-31 108.4 0.6 1.3e-30 106.1 0.4 2.2 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain CbiA PF01656.23 ADV23699.1 - 0.022 14.8 0.0 0.41 10.7 0.0 2.9 2 1 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain IF2_N PF04760.15 ADV23699.1 - 0.058 13.2 0.0 2.3 8.1 0.0 2.9 2 0 0 2 2 2 0 Translation initiation factor IF-2, N-terminal region WD40 PF00400.32 ADV23700.1 - 5.7e-05 23.8 0.2 2.5 9.1 0.0 4.9 5 0 0 5 5 5 2 WD domain, G-beta repeat F-box-like PF12937.7 ADV23700.1 - 0.00087 19.1 0.1 0.0015 18.3 0.1 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ADV23700.1 - 0.0019 18.0 0.1 0.0037 17.1 0.1 1.5 1 0 0 1 1 1 1 F-box domain zf-C3HC4_3 PF13920.6 ADV23701.1 - 4.4e-06 26.4 5.1 4.4e-06 26.4 5.1 3.3 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C2H2 PF00096.26 ADV23701.1 - 0.014 15.8 1.5 0.014 15.8 1.5 6.0 6 2 0 6 6 6 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ADV23701.1 - 0.027 15.3 1.1 0.027 15.3 1.1 6.4 7 1 0 7 7 7 0 C2H2-type zinc finger zf-BED PF02892.15 ADV23701.1 - 0.94 9.5 5.6 9.7 6.3 0.0 3.6 2 1 1 3 3 3 0 BED zinc finger Trehalase PF01204.18 ADV23702.1 - 2.6e-98 330.1 5.3 3e-87 293.6 0.0 2.1 2 0 0 2 2 2 2 Trehalase GDE_C PF06202.14 ADV23702.1 - 0.00041 19.4 0.2 0.00067 18.7 0.2 1.2 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase DRMBL PF07522.14 ADV23703.1 - 2.2e-32 111.5 0.0 2e-31 108.4 0.0 2.2 2 0 0 2 2 2 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.7 ADV23703.1 - 0.0057 16.2 0.0 0.011 15.3 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Fimbrial_PilY2 PF14481.6 ADV23703.1 - 0.051 13.2 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 Type 4 fimbrial biogenesis protein PilY2 Lactamase_B_2 PF12706.7 ADV23705.1 - 4.9e-17 62.1 0.3 6.9e-17 61.6 0.3 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 ADV23705.1 - 1.1e-08 35.1 0.3 2e-08 34.3 0.3 1.6 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 ADV23705.1 - 0.017 15.1 3.0 0.26 11.2 2.2 2.7 2 2 1 3 3 3 0 Metallo-beta-lactamase superfamily Yippee-Mis18 PF03226.14 ADV23706.1 - 4.7e-16 58.9 0.1 5.9e-16 58.6 0.1 1.1 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Jas PF16135.5 ADV23706.1 - 0.0066 16.6 0.4 1.6 8.9 0.1 2.2 2 0 0 2 2 2 2 TPL-binding domain in jasmonate signalling Zn_ribbon_SprT PF17283.2 ADV23706.1 - 0.012 15.4 1.0 4.2 7.4 0.2 2.3 2 0 0 2 2 2 0 SprT-like zinc ribbon domain HNH_5 PF14279.6 ADV23706.1 - 0.018 14.9 0.1 0.34 10.8 0.0 2.2 2 0 0 2 2 2 0 HNH endonuclease AlcCBM31 PF11606.8 ADV23706.1 - 0.021 15.0 0.1 0.86 9.8 0.0 2.1 1 1 1 2 2 2 0 Family 31 carbohydrate binding protein RIG-I_C-RD PF11648.8 ADV23706.1 - 0.028 14.6 0.2 0.042 14.1 0.2 1.2 1 0 0 1 1 1 0 C-terminal domain of RIG-I CBM_21 PF03370.13 ADV23708.1 - 5.5e-26 91.0 0.1 9.2e-26 90.2 0.1 1.4 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.5 ADV23708.1 - 3.7e-07 30.6 0.5 7.8e-07 29.6 0.5 1.5 1 0 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) Y_phosphatase2 PF03162.13 ADV23709.1 - 1.4e-55 187.3 0.0 2e-55 186.9 0.0 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 ADV23709.1 - 3.5e-06 27.2 0.0 5.1e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 ADV23709.1 - 0.00026 20.8 0.0 0.00036 20.3 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ADV23709.1 - 0.0032 17.1 0.0 0.0041 16.7 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase WD40 PF00400.32 ADV23710.1 - 1.3e-27 95.5 14.6 1e-05 26.2 0.0 5.6 5 0 0 5 5 5 4 WD domain, G-beta repeat CAF1C_H4-bd PF12265.8 ADV23710.1 - 9.5e-27 93.1 0.6 3.8e-26 91.1 0.6 2.1 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex ANAPC4_WD40 PF12894.7 ADV23710.1 - 2.5e-05 24.5 0.5 0.31 11.4 0.0 4.1 3 2 2 5 5 4 2 Anaphase-promoting complex subunit 4 WD40 domain ATP-synt_E PF05680.12 ADV23711.1 - 1.6e-25 89.2 0.2 1.8e-25 89.1 0.2 1.0 1 0 0 1 1 1 1 ATP synthase E chain BRO1 PF03097.18 ADV23712.1 - 6.4e-111 370.9 0.9 9.1e-111 370.4 0.9 1.2 1 0 0 1 1 1 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 ADV23712.1 - 5.6e-52 176.9 11.8 1.2e-51 175.8 11.8 1.5 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV DUF416 PF04222.12 ADV23712.1 - 0.11 12.0 0.4 0.26 10.7 0.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF416) Sld5 PF05916.11 ADV23713.1 - 5.7e-05 23.5 0.0 8.7e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 GINS complex protein CoA_binding PF02629.19 ADV23714.1 - 9.5e-30 103.2 0.8 9.5e-30 103.2 0.8 2.5 2 1 1 3 3 3 1 CoA binding domain Ligase_CoA PF00549.19 ADV23714.1 - 1.8e-24 86.3 0.5 4.7e-24 84.9 0.1 1.8 2 0 0 2 2 2 1 CoA-ligase Succ_CoA_lig PF13607.6 ADV23714.1 - 2.9e-09 36.8 0.4 1.1e-08 35.0 0.1 2.0 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 ADV23714.1 - 0.00034 21.1 0.2 0.0013 19.2 0.0 2.1 2 1 0 2 2 2 1 CoA binding domain GFO_IDH_MocA PF01408.22 ADV23714.1 - 0.0044 17.8 0.3 0.045 14.6 0.0 2.5 2 2 1 3 3 3 1 Oxidoreductase family, NAD-binding Rossmann fold AFG1_ATPase PF03969.16 ADV23716.1 - 4.4e-89 298.9 0.0 7.1e-86 288.3 0.0 2.1 2 0 0 2 2 2 2 AFG1-like ATPase AAA_16 PF13191.6 ADV23716.1 - 0.0002 21.8 0.1 0.013 15.9 0.1 2.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ADV23716.1 - 0.0014 18.9 0.0 0.0041 17.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 ADV23716.1 - 0.014 15.8 0.0 0.078 13.4 0.0 2.2 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ADV23716.1 - 0.026 14.5 0.1 0.3 11.1 0.1 2.4 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) RasGAP_C PF03836.15 ADV23716.1 - 0.032 14.4 0.1 0.074 13.2 0.0 1.6 2 0 0 2 2 2 0 RasGAP C-terminus Kinesin PF00225.23 ADV23717.1 - 9.3e-110 366.7 1.2 1.5e-109 366.0 0.2 1.9 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 ADV23717.1 - 2.9e-27 95.4 0.0 9e-27 93.8 0.0 1.9 1 0 0 1 1 1 1 Microtubule binding Microtub_bind PF13931.6 ADV23717.1 - 0.0017 18.7 0.0 0.0017 18.7 0.0 3.8 3 0 0 3 3 3 1 Kinesin-associated microtubule-binding WSC PF01822.19 ADV23718.1 - 3.1e-148 482.3 214.7 5e-17 61.9 14.1 11.5 11 0 0 11 11 11 11 WSC domain DUF1996 PF09362.10 ADV23718.1 - 9.7e-64 215.6 1.7 2.4e-63 214.3 1.7 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) adh_short_C2 PF13561.6 ADV23719.1 - 1.8e-18 67.0 0.7 2.7e-16 59.8 0.7 2.7 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ADV23719.1 - 6.7e-13 48.5 0.1 5.2e-10 39.1 0.2 2.7 2 1 0 2 2 2 2 short chain dehydrogenase GFO_IDH_MocA_C PF02894.17 ADV23720.1 - 6.2e-06 26.2 0.0 1.4e-05 25.0 0.0 1.6 2 0 0 2 2 2 1 Oxidoreductase family, C-terminal alpha/beta domain GFO_IDH_MocA PF01408.22 ADV23720.1 - 0.17 12.7 0.0 0.29 12.0 0.0 1.3 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold Fungal_trans PF04082.18 ADV23722.1 - 1.4e-10 40.7 0.0 2e-10 40.1 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain EthD PF07110.11 ADV23722.1 - 9.1e-09 36.4 0.0 2.2e-08 35.1 0.0 1.7 1 0 0 1 1 1 1 EthD domain MmlI PF09448.10 ADV23722.1 - 8e-08 32.7 0.0 1.6e-07 31.8 0.0 1.4 1 0 0 1 1 1 1 Methylmuconolactone methyl-isomerase Zn_clus PF00172.18 ADV23722.1 - 0.0035 17.4 4.2 0.0074 16.4 4.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain HeH PF12949.7 ADV23722.1 - 0.11 12.3 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 HeH/LEM domain DUF4820 PF16091.5 ADV23723.1 - 0.014 14.8 1.4 0.029 13.8 1.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Arrestin_C PF02752.22 ADV23725.1 - 7.9e-10 39.3 0.0 4.1e-09 37.0 0.0 2.2 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain MFS_1 PF07690.16 ADV23726.1 - 2e-36 125.6 29.1 3.5e-35 121.6 28.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF4064 PF13273.6 ADV23726.1 - 1 9.7 11.6 0.83 10.0 0.6 3.8 3 1 1 4 4 4 0 Protein of unknown function (DUF4064) ELP6 PF09807.9 ADV23727.1 - 1.5e-06 27.8 0.0 3.3e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 Elongation complex protein 6 Elong_Iki1 PF10483.9 ADV23727.1 - 0.0036 16.8 0.1 0.038 13.5 0.0 2.0 2 0 0 2 2 2 1 Elongator subunit Iki1 Acatn PF13000.7 ADV23728.1 - 2.9e-161 537.7 15.1 1.3e-81 274.8 7.7 3.0 1 1 1 2 2 2 2 Acetyl-coenzyme A transporter 1 MFS_1 PF07690.16 ADV23728.1 - 0.00037 19.5 23.6 0.00037 19.5 23.6 1.8 2 1 0 2 2 2 1 Major Facilitator Superfamily zf-C2H2_jaz PF12171.8 ADV23729.1 - 1.8e-08 34.4 0.0 3.7e-08 33.5 0.0 1.6 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 ADV23729.1 - 2.5e-07 30.8 0.1 4.6e-07 30.0 0.1 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type SNRNP27 PF08648.12 ADV23729.1 - 0.00052 20.0 1.7 0.00052 20.0 1.7 2.7 3 0 0 3 3 3 1 U4/U6.U5 small nuclear ribonucleoproteins zf-C2H2_4 PF13894.6 ADV23729.1 - 0.0082 16.9 0.1 0.018 15.8 0.1 1.6 1 0 0 1 1 1 1 C2H2-type zinc finger zf-DBF PF07535.12 ADV23729.1 - 0.011 15.8 0.1 0.029 14.5 0.1 1.6 1 0 0 1 1 1 0 DBF zinc finger zf-C2H2 PF00096.26 ADV23729.1 - 0.13 12.7 0.4 0.26 11.8 0.4 1.5 1 0 0 1 1 1 0 Zinc finger, C2H2 type UbiD PF01977.16 ADV23730.1 - 7.1e-116 387.4 0.0 8.3e-116 387.2 0.0 1.0 1 0 0 1 1 1 1 3-octaprenyl-4-hydroxybenzoate carboxy-lyase DEAD PF00270.29 ADV23732.1 - 8.9e-39 133.1 0.0 1.4e-38 132.4 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ADV23732.1 - 1.1e-29 103.0 0.0 2.1e-28 98.9 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ADV23732.1 - 5.4e-06 26.5 0.2 2.5e-05 24.4 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 ADV23732.1 - 0.0019 18.5 0.0 0.0082 16.4 0.0 2.1 1 1 0 1 1 1 1 AAA domain UTP25 PF06862.12 ADV23732.1 - 0.013 14.3 0.0 1.6 7.4 0.0 2.3 2 0 0 2 2 2 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 Dynactin_p62 PF05502.13 ADV23732.1 - 1.4 7.6 5.1 2.5 6.8 5.1 1.3 1 0 0 1 1 1 0 Dynactin p62 family Pkinase PF00069.25 ADV23734.1 - 1.7e-75 253.8 0.5 2.4e-75 253.3 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV23734.1 - 6.3e-36 124.0 0.0 6.3e-36 124.0 0.0 2.1 2 1 0 2 2 2 1 Protein tyrosine kinase Haspin_kinase PF12330.8 ADV23734.1 - 0.00063 18.8 4.5 0.0008 18.5 0.1 2.7 2 1 0 2 2 2 1 Haspin like kinase domain Kinase-like PF14531.6 ADV23734.1 - 0.027 13.8 0.0 0.027 13.8 0.0 1.9 2 0 0 2 2 2 0 Kinase-like APH PF01636.23 ADV23734.1 - 0.15 12.0 0.1 0.15 12.0 0.1 2.6 2 1 0 2 2 2 0 Phosphotransferase enzyme family HAUS6_N PF14661.6 ADV23734.1 - 1.1 8.7 10.4 1.8 8.1 10.4 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus DUF3330 PF11809.8 ADV23734.1 - 9 6.4 0.0 9 6.4 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF3330) eIF2A PF08662.11 ADV23735.1 - 7e-80 267.5 0.0 2.2e-79 265.8 0.0 1.7 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A WD40 PF00400.32 ADV23735.1 - 0.011 16.6 0.2 16 6.6 0.1 4.1 3 2 1 4 4 4 0 WD domain, G-beta repeat CDV3 PF15359.6 ADV23735.1 - 3.6 8.1 7.3 0.26 11.8 0.6 2.3 2 0 0 2 2 2 0 Carnitine deficiency-associated protein 3 Glyco_hydro_3_C PF01915.22 ADV23736.1 - 7.8e-61 205.6 0.0 1.5e-60 204.7 0.0 1.5 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 ADV23736.1 - 1.3e-47 162.7 0.0 3e-47 161.5 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 ADV23736.1 - 8.2e-16 57.9 0.1 2e-15 56.6 0.1 1.7 1 0 0 1 1 1 1 Fibronectin type III-like domain PA14 PF07691.12 ADV23736.1 - 6e-12 45.6 0.0 1.3e-11 44.5 0.0 1.5 1 0 0 1 1 1 1 PA14 domain RRM_1 PF00076.22 ADV23737.1 - 0.0067 16.2 0.0 0.016 15.1 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Macoilin PF09726.9 ADV23737.1 - 4.4 5.8 14.5 8.4 4.8 14.5 1.4 1 0 0 1 1 1 0 Macoilin family Dus PF01207.17 ADV23738.1 - 2.1e-55 188.0 0.0 3e-55 187.5 0.0 1.1 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) zf_CCCH_4 PF18345.1 ADV23738.1 - 0.00047 20.1 6.0 0.024 14.7 0.8 3.0 2 1 0 2 2 2 2 Zinc finger domain zf-CCCH PF00642.24 ADV23738.1 - 0.0024 17.7 6.7 0.48 10.4 0.4 2.9 2 1 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Mit_KHE1 PF10173.9 ADV23738.1 - 0.073 13.2 1.5 0.13 12.3 1.5 1.4 1 0 0 1 1 1 0 Mitochondrial K+-H+ exchange-related zf-CCCH_4 PF18044.1 ADV23738.1 - 8.1 6.4 8.1 0.76 9.6 0.9 2.5 2 1 0 2 2 2 0 CCCH-type zinc finger 2-Hacid_dh_C PF02826.19 ADV23739.1 - 1.6e-43 148.2 0.0 2.4e-42 144.3 0.0 2.1 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GST_C_6 PF17171.4 ADV23740.1 - 7.7e-16 57.6 0.0 1.3e-15 56.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 ADV23740.1 - 5.2e-09 36.0 0.1 1.3e-08 34.7 0.1 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Tom37 PF10568.9 ADV23740.1 - 8.5e-08 32.6 0.0 1.8e-07 31.5 0.0 1.6 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_C_3 PF14497.6 ADV23740.1 - 1.9e-05 24.8 0.0 9.5e-05 22.5 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ADV23740.1 - 0.0001 22.4 0.9 0.00024 21.3 0.0 2.0 2 1 1 3 3 3 1 Glutathione S-transferase, C-terminal domain ABC_tran PF00005.27 ADV23741.1 - 3.5e-43 147.4 0.0 3.2e-27 95.7 0.1 2.5 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 ADV23741.1 - 5.4e-15 55.8 21.6 2.8e-09 37.0 0.6 4.0 3 1 0 3 3 3 2 ABC transporter transmembrane region SMC_N PF02463.19 ADV23741.1 - 6.2e-07 29.1 0.7 0.012 15.1 1.4 3.7 2 2 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 ADV23741.1 - 2.1e-05 25.0 0.0 0.43 10.9 0.0 2.9 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 ADV23741.1 - 9e-05 22.8 0.2 0.12 12.6 0.0 2.9 2 1 0 2 2 2 1 AAA domain AAA_29 PF13555.6 ADV23741.1 - 0.00024 20.8 1.4 0.69 9.7 0.1 3.5 3 0 0 3 3 3 2 P-loop containing region of AAA domain AAA_25 PF13481.6 ADV23741.1 - 0.00025 20.7 0.3 0.35 10.4 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA PF00004.29 ADV23741.1 - 0.00051 20.5 0.2 0.28 11.6 0.0 2.9 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 ADV23741.1 - 0.0014 18.6 0.3 0.17 11.9 0.1 2.5 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE cobW PF02492.19 ADV23741.1 - 0.0016 18.1 1.3 0.12 11.9 0.1 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.6 ADV23741.1 - 0.0018 18.5 0.0 2.4 8.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain T2SSE PF00437.20 ADV23741.1 - 0.0056 15.8 0.0 2.7 7.0 0.0 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein NB-ARC PF00931.22 ADV23741.1 - 0.0065 15.7 0.0 0.026 13.7 0.0 1.9 2 1 0 2 2 2 1 NB-ARC domain AAA_21 PF13304.6 ADV23741.1 - 0.0078 16.0 0.0 10 5.8 0.0 3.3 3 0 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_7 PF12775.7 ADV23741.1 - 0.008 15.7 0.2 4 6.9 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_23 PF13476.6 ADV23741.1 - 0.013 16.0 0.1 4.1 7.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 ADV23741.1 - 0.023 14.4 0.1 3.5 7.3 0.1 2.4 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 ADV23741.1 - 0.024 14.5 1.4 6.7 6.6 0.2 2.8 2 0 0 2 2 2 0 NACHT domain AAA_18 PF13238.6 ADV23741.1 - 0.036 14.6 0.3 2.2 8.8 0.0 2.6 2 0 0 2 2 2 0 AAA domain TrwB_AAD_bind PF10412.9 ADV23741.1 - 0.039 12.9 0.2 0.67 8.8 0.1 2.1 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain RsgA_GTPase PF03193.16 ADV23741.1 - 0.058 13.3 0.2 11 5.8 0.1 2.5 2 0 0 2 2 2 0 RsgA GTPase DUF87 PF01935.17 ADV23741.1 - 0.08 13.0 0.2 0.19 11.8 0.2 1.5 1 0 0 1 1 1 0 Helicase HerA, central domain Zeta_toxin PF06414.12 ADV23741.1 - 0.088 12.1 0.5 8.2 5.6 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin IstB_IS21 PF01695.17 ADV23741.1 - 0.091 12.5 0.0 19 5.0 0.0 2.6 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_5 PF07728.14 ADV23741.1 - 0.2 11.6 1.3 4.8 7.2 0.1 2.6 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 ADV23741.1 - 0.21 12.0 0.1 6.3 7.2 0.0 3.0 2 0 0 2 2 2 0 RNA helicase Pox_A32 PF04665.12 ADV23741.1 - 0.37 10.2 1.2 0.89 9.0 0.1 2.1 2 0 0 2 2 2 0 Poxvirus A32 protein DUF2075 PF09848.9 ADV23741.1 - 0.44 9.7 1.4 1.8 7.7 0.2 2.4 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) MFS_1 PF07690.16 ADV23742.1 - 2e-41 142.1 34.6 1.1e-40 139.6 28.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ADV23742.1 - 1.9e-06 27.0 7.6 1.9e-06 27.0 7.6 2.5 2 1 0 2 2 2 1 Sugar (and other) transporter CTK3 PF12243.8 ADV23743.1 - 1.5e-45 154.2 0.0 2.1e-45 153.7 0.0 1.2 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 P66_CC PF16563.5 ADV23743.1 - 0.083 12.5 0.3 0.22 11.1 0.3 1.6 1 0 0 1 1 1 0 Coiled-coil and interaction region of P66A and P66B with MBD2 Vfa1 PF08432.10 ADV23744.1 - 1.9e-34 119.6 0.0 2.1e-34 119.4 0.0 1.0 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 DUF2956 PF11169.8 ADV23744.1 - 0.051 13.8 0.9 0.09 13.0 0.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2956) CSTF2_hinge PF14327.6 ADV23745.1 - 1.8e-29 102.0 3.9 1.8e-29 102.0 3.9 2.4 2 0 0 2 2 2 1 Hinge domain of cleavage stimulation factor subunit 2 RRM_1 PF00076.22 ADV23745.1 - 6.3e-20 70.8 0.1 9.8e-20 70.2 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CSTF_C PF14304.6 ADV23745.1 - 8.7e-09 34.8 17.0 3.8e-08 32.8 13.4 3.1 1 1 2 3 3 3 1 Transcription termination and cleavage factor C-terminal RRM_7 PF16367.5 ADV23745.1 - 0.0012 19.0 0.0 0.0024 17.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif PHM7_cyt PF14703.6 ADV23745.1 - 0.033 14.4 0.0 0.73 10.1 0.0 2.2 1 1 1 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter RRM_5 PF13893.6 ADV23745.1 - 0.045 13.4 0.0 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ADV23745.1 - 0.19 11.6 0.0 0.36 10.7 0.0 1.4 1 0 0 1 1 1 0 Occluded RNA-recognition motif Iso_dh PF00180.20 ADV23747.1 - 6.4e-92 308.4 0.0 7.7e-92 308.1 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Fungal_trans PF04082.18 ADV23748.1 - 2.5e-23 82.5 0.4 3.8e-23 81.9 0.4 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ADV23748.1 - 1.3e-05 25.3 9.3 2.3e-05 24.4 9.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ECH_1 PF00378.20 ADV23749.1 - 2.5e-78 262.9 0.1 2.9e-78 262.6 0.1 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ADV23749.1 - 6.3e-36 124.5 1.0 2.2e-32 112.9 0.2 2.1 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase COX16 PF14138.6 ADV23750.1 - 4e-27 94.5 0.1 5.6e-22 78.1 0.0 2.1 2 0 0 2 2 2 2 Cytochrome c oxidase assembly protein COX16 DUF1093 PF06486.11 ADV23750.1 - 0.046 14.4 0.7 0.077 13.7 0.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1093) SLC3A2_N PF16028.5 ADV23750.1 - 0.095 12.3 0.3 0.26 10.9 0.0 1.7 1 1 1 2 2 2 0 Solute carrier family 3 member 2 N-terminus Rsm1 PF08600.10 ADV23751.1 - 1.3e-26 92.6 2.2 1.2e-24 86.3 0.1 2.3 2 0 0 2 2 2 2 Rsm1-like zf-C3HC PF07967.13 ADV23751.1 - 5e-24 84.8 0.0 2.2e-23 82.8 0.0 1.9 2 0 0 2 2 2 1 C3HC zinc finger-like Reprolysin_5 PF13688.6 ADV23752.1 - 6e-43 147.3 4.7 6e-43 147.3 4.7 2.9 3 0 0 3 3 3 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.6 ADV23752.1 - 6.3e-42 143.5 2.0 1.2e-41 142.7 2.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 ADV23752.1 - 7.7e-40 136.9 2.3 2.1e-39 135.4 2.3 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Disintegrin PF00200.23 ADV23752.1 - 4.1e-17 62.8 25.8 4.1e-17 62.8 25.8 4.5 3 1 0 3 3 3 1 Disintegrin Reprolysin_3 PF13582.6 ADV23752.1 - 1.4e-11 44.9 0.6 3.5e-11 43.7 0.0 2.0 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin PF01421.19 ADV23752.1 - 2.6e-05 24.2 4.9 7.2e-05 22.8 4.5 1.9 1 1 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR_2 PF17771.1 ADV23752.1 - 0.00026 21.4 12.0 0.00026 21.4 12.0 4.0 1 1 2 3 3 3 1 ADAM cysteine-rich domain Myc_target_1 PF15179.6 ADV23752.1 - 0.08 12.8 0.1 0.17 11.7 0.1 1.5 1 0 0 1 1 1 0 Myc target protein 1 DUF3574 PF12098.8 ADV23752.1 - 0.2 11.5 0.0 0.48 10.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3574) adh_short PF00106.25 ADV23753.1 - 7e-48 162.7 0.0 9.1e-48 162.3 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ADV23753.1 - 2e-35 122.5 0.0 2.6e-35 122.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ADV23753.1 - 1.2e-10 41.6 0.0 1.5e-10 41.3 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ADV23753.1 - 0.0002 20.9 0.0 0.00034 20.2 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family THF_DHG_CYH_C PF02882.19 ADV23753.1 - 0.00098 18.5 0.0 0.017 14.4 0.0 2.3 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Polysacc_synt_2 PF02719.15 ADV23753.1 - 0.0059 15.8 0.0 0.0082 15.3 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 ADV23753.1 - 0.01 14.9 0.0 0.014 14.5 0.0 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain NmrA PF05368.13 ADV23753.1 - 0.019 14.5 0.0 0.029 13.9 0.0 1.2 1 0 0 1 1 1 0 NmrA-like family 2-Hacid_dh_C PF02826.19 ADV23753.1 - 0.032 13.6 0.2 0.059 12.7 0.2 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ApbA PF02558.16 ADV23753.1 - 0.035 13.7 0.0 0.06 13.0 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA ADH_zinc_N PF00107.26 ADV23753.1 - 0.06 13.3 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Urocanase PF01175.18 ADV23753.1 - 0.11 12.2 0.2 0.22 11.2 0.2 1.4 1 0 0 1 1 1 0 Urocanase Rossmann-like domain PGM_PMM_II PF02879.16 ADV23753.1 - 0.13 12.9 0.0 0.24 12.1 0.0 1.4 1 0 0 1 1 1 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II 3HCDH_N PF02737.18 ADV23753.1 - 0.18 11.7 0.0 0.25 11.2 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Acyltransferase PF01553.21 ADV23754.1 - 0.014 15.1 0.1 0.051 13.2 0.0 1.8 2 0 0 2 2 2 0 Acyltransferase Pyr_redox_2 PF07992.14 ADV23755.1 - 2.8e-35 122.0 0.0 4.6e-35 121.3 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ADV23755.1 - 1.6e-15 57.4 0.1 7.8e-12 45.6 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ADV23755.1 - 2e-08 33.9 0.0 9.1e-08 31.7 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ADV23755.1 - 4.9e-07 29.7 1.6 0.044 13.4 0.1 3.8 3 1 1 4 4 4 2 FAD dependent oxidoreductase Trp_halogenase PF04820.14 ADV23755.1 - 9.4e-06 24.7 0.0 0.51 9.1 0.0 3.1 3 0 0 3 3 3 2 Tryptophan halogenase Lycopene_cycl PF05834.12 ADV23755.1 - 9.9e-05 21.6 0.8 0.031 13.3 0.1 3.1 2 2 2 4 4 4 2 Lycopene cyclase protein K_oxygenase PF13434.6 ADV23755.1 - 0.00029 20.1 0.0 0.00044 19.5 0.0 1.2 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.14 ADV23755.1 - 0.0021 16.8 0.1 0.29 9.8 0.1 2.3 1 1 1 2 2 2 2 HI0933-like protein NAD_binding_8 PF13450.6 ADV23755.1 - 0.02 15.1 0.0 2.5 8.4 0.0 2.3 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain NAD_binding_7 PF13241.6 ADV23755.1 - 0.051 14.0 0.1 2.6 8.5 0.0 2.4 2 0 0 2 2 2 0 Putative NAD(P)-binding Thi4 PF01946.17 ADV23755.1 - 0.091 12.0 0.2 1.9 7.6 0.1 2.3 2 0 0 2 2 2 0 Thi4 family TrkA_N PF02254.18 ADV23755.1 - 0.12 12.7 0.0 4.9 7.4 0.0 2.3 2 0 0 2 2 2 0 TrkA-N domain Mqo PF06039.15 ADV23755.1 - 0.19 10.2 0.0 0.27 9.7 0.0 1.1 1 0 0 1 1 1 0 Malate:quinone oxidoreductase (Mqo) Amidohydro_3 PF07969.11 ADV23756.1 - 1.1e-26 94.4 0.0 2.8e-26 93.0 0.0 1.6 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_1 PF01979.20 ADV23756.1 - 1.4e-07 31.2 0.0 0.00024 20.5 0.0 2.4 2 0 0 2 2 2 2 Amidohydrolase family D-ser_dehydrat PF14031.6 ADV23757.1 - 2.7e-25 88.8 0.3 1.5e-24 86.5 0.0 2.3 3 0 0 3 3 3 1 Putative serine dehydratase domain Ala_racemase_N PF01168.20 ADV23757.1 - 1.8e-18 67.0 0.4 2.5e-18 66.6 0.4 1.1 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain Carmo_coat_C PF08462.10 ADV23757.1 - 0.12 12.5 0.4 1.1 9.4 0.1 2.1 2 0 0 2 2 2 0 Carmovirus coat protein LZ3wCH PF18517.1 ADV23758.1 - 0.01 15.9 0.1 0.023 14.8 0.1 1.6 1 0 0 1 1 1 0 Leucine zipper with capping helix domain V-SNARE PF05008.15 ADV23758.1 - 0.085 13.3 2.3 0.18 12.2 2.3 1.6 1 1 0 1 1 1 0 Vesicle transport v-SNARE protein N-terminus DUF4407 PF14362.6 ADV23758.1 - 0.35 10.2 3.7 0.46 9.8 3.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Gp_dh_C PF02800.20 ADV23759.1 - 7.3e-53 178.4 0.0 1.3e-52 177.5 0.0 1.4 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 ADV23759.1 - 3.5e-29 101.1 0.0 7.7e-29 100.0 0.0 1.6 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.20 ADV23759.1 - 0.094 12.8 0.4 0.32 11.1 0.0 2.1 3 0 0 3 3 3 0 Dihydrodipicolinate reductase, N-terminus Gaa1 PF04114.14 ADV23760.1 - 7.5e-77 259.4 7.1 2.5e-71 241.2 0.0 3.1 1 1 2 3 3 3 3 Gaa1-like, GPI transamidase component TerD PF02342.18 ADV23760.1 - 0.14 11.6 0.0 0.24 10.9 0.0 1.3 1 0 0 1 1 1 0 TerD domain UBX PF00789.20 ADV23763.1 - 1.1e-13 51.1 0.2 4.2e-13 49.3 0.0 2.1 2 0 0 2 2 2 1 UBX domain UBA PF00627.31 ADV23763.1 - 0.00094 19.0 0.0 0.0033 17.3 0.0 2.0 1 0 0 1 1 1 1 UBA/TS-N domain zf-C2H2_2 PF12756.7 ADV23763.1 - 0.019 15.3 0.3 0.059 13.7 0.2 1.8 1 1 0 1 1 1 0 C2H2 type zinc-finger (2 copies) SOBP PF15279.6 ADV23763.1 - 2.8 8.5 4.8 3.7 8.1 4.8 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein EIF_2_alpha PF07541.12 ADV23764.1 - 9e-38 128.9 0.0 1.9e-37 127.9 0.0 1.6 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 ADV23764.1 - 3.9e-13 49.5 0.7 3.9e-13 49.5 0.7 2.5 3 0 0 3 3 3 1 S1 RNA binding domain NusA_N PF08529.11 ADV23764.1 - 0.032 14.6 3.2 4.5 7.7 0.0 3.4 2 1 1 3 3 3 0 NusA N-terminal domain Zeta_toxin PF06414.12 ADV23765.1 - 0.068 12.4 0.0 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_16 PF13191.6 ADV23765.1 - 0.13 12.7 0.0 0.21 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain MFS_1 PF07690.16 ADV23766.1 - 3.5e-38 131.4 37.4 3.5e-37 128.2 22.9 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily ATPase_gene1 PF09527.10 ADV23766.1 - 0.99 9.6 12.8 0.57 10.4 0.2 3.7 3 0 0 3 3 3 0 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter ATG7_N PF16420.5 ADV23767.1 - 1.8e-72 244.5 0.0 2.7e-72 244.0 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-like modifier-activating enzyme ATG7 N-terminus ThiF PF00899.21 ADV23767.1 - 1e-40 139.6 0.0 1.7e-40 138.9 0.0 1.3 1 0 0 1 1 1 1 ThiF family Shikimate_DH PF01488.20 ADV23767.1 - 0.068 13.2 0.0 0.19 11.8 0.0 1.7 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 ADV23767.1 - 0.13 11.6 0.0 1.1 8.6 0.0 2.1 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain SURF1 PF02104.15 ADV23768.1 - 6.1e-35 121.1 0.0 7.9e-35 120.7 0.0 1.1 1 0 0 1 1 1 1 SURF1 family Sec62 PF03839.16 ADV23769.1 - 3.1e-49 167.4 5.3 2.3e-48 164.6 5.3 2.0 1 1 0 1 1 1 1 Translocation protein Sec62 polyprenyl_synt PF00348.17 ADV23770.1 - 6.6e-61 205.6 0.0 8e-61 205.3 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase SecY PF00344.20 ADV23771.1 - 1.4e-73 247.9 9.7 1.8e-73 247.5 9.7 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.9 ADV23771.1 - 1.5e-18 66.3 0.2 5.4e-18 64.5 0.2 2.1 1 0 0 1 1 1 1 Plug domain of Sec61p HlyIII PF03006.20 ADV23772.1 - 2.1e-53 181.3 17.5 2.6e-53 181.0 17.5 1.0 1 0 0 1 1 1 1 Haemolysin-III related DUF1772 PF08592.11 ADV23772.1 - 3.4 8.0 6.7 1.2 9.5 1.3 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF1772) Gly_transf_sug PF04488.15 ADV23773.1 - 2.7e-18 66.4 0.0 5.1e-18 65.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif GPDPase_memb PF10110.9 ADV23773.1 - 0.1 11.3 0.4 0.16 10.7 0.4 1.1 1 0 0 1 1 1 0 Membrane domain of glycerophosphoryl diester phosphodiesterase Caps_synth PF05704.12 ADV23773.1 - 0.15 11.4 0.0 0.22 10.8 0.0 1.2 1 0 0 1 1 1 0 Capsular polysaccharide synthesis protein Pribosyltran_N PF13793.6 ADV23774.1 - 2.7e-45 153.0 0.0 5.9e-45 152.0 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 ADV23774.1 - 4.4e-38 131.2 0.1 7.5e-38 130.4 0.1 1.4 1 0 0 1 1 1 1 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 ADV23774.1 - 8.6e-16 57.8 0.9 6.5e-14 51.7 0.1 2.7 2 1 0 2 2 2 2 Phosphoribosyl transferase domain UPRTase PF14681.6 ADV23774.1 - 0.0003 20.3 0.2 0.00051 19.6 0.2 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase SYF2 PF08231.12 ADV23775.1 - 1.2e-53 181.8 12.4 1.2e-53 181.8 12.4 2.4 2 1 0 2 2 2 1 SYF2 splicing factor SMC_Nse1 PF07574.13 ADV23776.1 - 1e-24 87.6 0.8 1.3e-23 83.9 0.8 2.2 1 1 0 1 1 1 1 Nse1 non-SMC component of SMC5-6 complex zf-RING-like PF08746.11 ADV23776.1 - 1.4e-08 34.8 13.9 2.4e-08 34.2 13.9 1.4 1 0 0 1 1 1 1 RING-like domain Baculo_IE-1 PF05290.11 ADV23776.1 - 0.0008 19.4 1.4 0.0014 18.6 1.4 1.4 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) FYDLN_acid PF09538.10 ADV23776.1 - 0.0088 16.7 4.0 0.017 15.8 4.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (FYDLN_acid) zf-HC5HC2H PF13771.6 ADV23776.1 - 0.015 15.5 5.8 0.03 14.6 5.8 1.5 1 0 0 1 1 1 0 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 ADV23776.1 - 0.038 14.1 3.8 0.07 13.3 3.8 1.4 1 0 0 1 1 1 0 PHD-zinc-finger like domain YdjO PF14169.6 ADV23776.1 - 1.1 9.0 5.1 2.9 7.7 5.1 1.7 1 0 0 1 1 1 0 Cold-inducible protein YdjO DNA_pol_phi PF04931.13 ADV23776.1 - 1.5 6.8 6.2 2.3 6.2 6.2 1.2 1 0 0 1 1 1 0 DNA polymerase phi Trypan_PARP PF05887.11 ADV23776.1 - 2.3 8.2 10.2 3.7 7.5 10.2 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) FAM176 PF14851.6 ADV23776.1 - 2.6 7.7 6.6 4.6 6.9 6.6 1.3 1 0 0 1 1 1 0 FAM176 family Nop14 PF04147.12 ADV23776.1 - 3 6.0 12.0 4.1 5.5 12.0 1.1 1 0 0 1 1 1 0 Nop14-like family zf-RING_10 PF16685.5 ADV23776.1 - 3.2 7.9 8.5 5.6 7.2 8.5 1.3 1 0 0 1 1 1 0 zinc RING finger of MSL2 DUF1691 PF07950.11 ADV23777.1 - 2.3e-05 25.1 0.3 4.6e-05 24.1 0.3 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1691) Ferric_reduct PF01794.19 ADV23777.1 - 0.24 11.5 3.1 0.23 11.6 0.5 2.1 3 0 0 3 3 3 0 Ferric reductase like transmembrane component HECT PF00632.25 ADV23779.1 - 9e-95 317.7 0.0 1.2e-94 317.3 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.26 ADV23779.1 - 4e-35 119.6 14.8 1.2e-12 47.7 2.5 3.8 3 0 0 3 3 3 3 WW domain C2 PF00168.30 ADV23779.1 - 2.3e-19 69.6 0.1 5.1e-19 68.5 0.1 1.6 1 0 0 1 1 1 1 C2 domain Nucleoporin_C PF03177.14 ADV23780.1 - 4.5e-76 256.9 0.0 6e-76 256.5 0.0 1.1 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal Nucleoporin_N PF08801.11 ADV23780.1 - 1.2e-31 109.9 0.1 1.8e-31 109.4 0.1 1.2 1 0 0 1 1 1 1 Nup133 N terminal like PMM PF03332.13 ADV23781.1 - 5e-104 346.9 0.5 6e-104 346.6 0.5 1.0 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase Hydrolase_3 PF08282.12 ADV23781.1 - 1.8e-05 24.6 0.0 0.00013 21.8 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 ADV23781.1 - 0.0071 15.9 0.0 0.82 9.2 0.0 2.1 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Di19_C PF14571.6 ADV23782.1 - 3.1 8.4 8.9 0.29 11.7 3.8 1.9 2 0 0 2 2 2 0 Stress-induced protein Di19, C-terminal Ras PF00071.22 ADV23784.1 - 1.2e-51 174.6 0.0 1.3e-51 174.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ADV23784.1 - 2.1e-18 66.7 0.0 3e-18 66.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ADV23784.1 - 1.6e-06 27.7 0.0 2.3e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ADV23784.1 - 0.21 11.1 0.0 1.6 8.2 0.0 2.2 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain Redoxin PF08534.10 ADV23785.1 - 8.6e-28 96.9 0.1 1.1e-27 96.6 0.1 1.1 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 ADV23785.1 - 4.9e-11 42.6 0.0 6.3e-11 42.3 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family HlyIII PF03006.20 ADV23786.1 - 2.8e-46 158.0 23.0 3.6e-46 157.7 23.0 1.1 1 0 0 1 1 1 1 Haemolysin-III related TssN PF17555.2 ADV23786.1 - 0.069 12.5 3.8 0.11 11.9 3.8 1.2 1 0 0 1 1 1 0 Type VI secretion system, TssN DUF962 PF06127.11 ADV23786.1 - 0.079 13.1 1.7 0.95 9.6 1.7 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF962) DUF3054 PF11255.8 ADV23786.1 - 4.3 7.9 11.8 3.7 8.1 5.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3054) Sugar_tr PF00083.24 ADV23787.1 - 4.8e-111 371.8 16.6 1.2e-110 370.5 16.6 1.5 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ADV23787.1 - 2.7e-31 108.8 50.4 5.4e-30 104.5 24.3 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF423 PF04241.15 ADV23787.1 - 6.1 7.1 10.7 1.4 9.2 0.4 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF423) Ribonuc_L-PSP PF01042.21 ADV23788.1 - 6.4e-21 74.6 0.0 7.4e-21 74.4 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP BNR_2 PF13088.6 ADV23792.1 - 2.6e-54 184.4 0.1 4.7e-54 183.6 0.1 1.3 1 1 0 1 1 1 1 BNR repeat-like domain BNR PF02012.20 ADV23792.1 - 0.0002 20.9 10.5 0.81 9.9 0.0 5.1 4 0 0 4 4 4 3 BNR/Asp-box repeat GFO_IDH_MocA PF01408.22 ADV23793.1 - 8.4e-07 29.8 0.0 1.5e-06 29.0 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Sugar_tr PF00083.24 ADV23794.1 - 1.7e-88 297.5 24.7 2.1e-88 297.2 24.7 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ADV23794.1 - 1.8e-17 63.4 37.6 2.5e-17 62.8 26.9 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Adaptin_N PF01602.20 ADV23795.1 - 8.3e-13 47.7 0.1 1.1e-12 47.4 0.1 1.1 1 0 0 1 1 1 1 Adaptin N terminal region MMS19_N PF14500.6 ADV23795.1 - 0.0061 16.2 0.0 0.0093 15.6 0.0 1.3 1 0 0 1 1 1 1 Dos2-interacting transcription regulator of RNA-Pol-II RNA_pol_Rpb2_6 PF00562.28 ADV23796.1 - 6.2e-119 397.5 0.8 9e-119 397.0 0.0 1.6 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 ADV23796.1 - 1.1e-53 181.8 0.1 1.6e-53 181.3 0.1 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_7 PF04560.20 ADV23796.1 - 4.7e-31 107.0 0.3 1.1e-30 105.9 0.3 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_2 PF04561.14 ADV23796.1 - 1.1e-27 96.9 0.1 3.3e-27 95.4 0.2 1.7 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_4 PF04566.13 ADV23796.1 - 1.3e-25 89.4 1.2 3e-25 88.3 1.2 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.16 ADV23796.1 - 3.4e-20 72.0 0.0 7.4e-20 70.9 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 ADV23796.1 - 2.4e-10 40.8 1.3 6.5e-10 39.4 1.3 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 AAA PF00004.29 ADV23797.1 - 7.2e-43 146.2 0.0 1.4e-42 145.2 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 ADV23797.1 - 1.6e-25 88.8 0.1 4.5e-25 87.4 0.1 1.8 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain MIT PF04212.18 ADV23797.1 - 6.9e-23 80.5 9.7 6.9e-23 80.5 9.7 1.9 2 0 0 2 2 1 1 MIT (microtubule interacting and transport) domain AAA_lid_3 PF17862.1 ADV23797.1 - 3.2e-08 33.2 0.0 1.2e-07 31.4 0.0 2.0 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 ADV23797.1 - 9.9e-07 29.3 0.8 0.00083 19.8 0.0 3.0 2 1 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 ADV23797.1 - 5.9e-06 26.6 1.2 0.021 15.1 0.0 2.7 2 1 1 3 3 3 2 AAA domain RuvB_N PF05496.12 ADV23797.1 - 1.3e-05 25.0 0.0 2.7e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 ADV23797.1 - 3e-05 24.0 0.0 0.00016 21.6 0.0 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 ADV23797.1 - 3.6e-05 23.8 0.1 0.00019 21.5 0.0 2.0 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.13 ADV23797.1 - 3.7e-05 23.1 0.2 0.00011 21.5 0.0 1.8 2 0 0 2 2 2 1 TIP49 P-loop domain IstB_IS21 PF01695.17 ADV23797.1 - 4e-05 23.4 0.0 0.00012 21.9 0.0 1.7 2 0 0 2 2 2 1 IstB-like ATP binding protein RNA_helicase PF00910.22 ADV23797.1 - 0.00027 21.3 0.0 0.0083 16.5 0.0 2.8 2 0 0 2 2 2 1 RNA helicase AAA_2 PF07724.14 ADV23797.1 - 0.00052 20.2 0.3 0.0038 17.4 0.0 2.2 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 ADV23797.1 - 0.00056 19.2 0.0 0.0018 17.5 0.0 1.8 1 1 1 2 2 2 1 Protein of unknown function (DUF815) AAA_18 PF13238.6 ADV23797.1 - 0.0007 20.1 0.1 0.0026 18.3 0.0 2.1 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.6 ADV23797.1 - 0.001 19.3 0.1 0.0034 17.6 0.0 1.9 2 0 0 2 2 1 1 AAA domain AAA_24 PF13479.6 ADV23797.1 - 0.0011 18.7 0.4 0.012 15.3 0.0 2.5 2 1 1 3 3 3 1 AAA domain AAA_25 PF13481.6 ADV23797.1 - 0.0071 15.9 0.1 0.76 9.3 0.1 2.4 1 1 0 2 2 2 1 AAA domain NACHT PF05729.12 ADV23797.1 - 0.0084 16.0 0.0 0.21 11.5 0.0 2.7 2 1 0 2 2 2 1 NACHT domain AAA_17 PF13207.6 ADV23797.1 - 0.011 16.2 0.5 0.039 14.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain TniB PF05621.11 ADV23797.1 - 0.019 14.4 0.4 4.6 6.6 0.0 2.7 2 1 0 3 3 3 0 Bacterial TniB protein ATPase PF06745.13 ADV23797.1 - 0.027 13.8 0.1 5.6 6.2 0.0 2.3 1 1 1 2 2 2 0 KaiC Mg_chelatase PF01078.21 ADV23797.1 - 0.035 13.5 0.1 0.082 12.3 0.0 1.6 2 0 0 2 2 1 0 Magnesium chelatase, subunit ChlI KAP_NTPase PF07693.14 ADV23797.1 - 0.048 12.9 0.5 2.7 7.1 0.0 2.5 2 1 1 3 3 3 0 KAP family P-loop domain AAA_7 PF12775.7 ADV23797.1 - 0.051 13.1 0.0 0.16 11.5 0.0 1.8 1 1 0 1 1 1 0 P-loop containing dynein motor region Parvo_NS1 PF01057.17 ADV23797.1 - 0.058 12.5 0.0 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Sigma54_activ_2 PF14532.6 ADV23797.1 - 0.06 13.5 0.0 0.4 10.8 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain Sigma54_activat PF00158.26 ADV23797.1 - 0.081 12.6 0.0 0.38 10.4 0.0 2.1 1 1 0 1 1 1 0 Sigma-54 interaction domain Torsin PF06309.11 ADV23797.1 - 0.15 12.1 0.0 0.36 10.9 0.0 1.6 1 0 0 1 1 1 0 Torsin CPT PF07931.12 ADV23797.1 - 0.16 11.8 0.1 0.46 10.3 0.0 1.8 2 0 0 2 2 1 0 Chloramphenicol phosphotransferase-like protein PhoH PF02562.16 ADV23797.1 - 0.17 11.3 1.7 0.18 11.2 0.1 1.8 2 0 0 2 2 2 0 PhoH-like protein ATPase_2 PF01637.18 ADV23797.1 - 0.18 11.7 2.7 1.4 8.8 0.0 2.8 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea DUF4407 PF14362.6 ADV23797.1 - 0.27 10.5 2.3 0.42 9.9 2.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Kelch_2 PF07646.15 ADV23799.1 - 0.057 13.4 0.2 0.16 12.0 0.2 1.7 1 0 0 1 1 1 0 Kelch motif G-alpha PF00503.20 ADV23800.1 - 1.8e-116 389.2 0.8 2.2e-116 388.9 0.8 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ADV23800.1 - 6.4e-16 58.3 0.5 1.2e-10 41.1 0.0 2.5 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ADV23800.1 - 4.5e-05 22.9 0.8 0.045 13.1 0.0 2.3 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 ADV23800.1 - 0.0066 16.7 0.3 1.3 9.3 0.1 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 ADV23800.1 - 0.065 13.0 0.0 0.2 11.4 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.18 ADV23800.1 - 0.15 11.4 0.0 0.27 10.5 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family DUF1479 PF07350.12 ADV23801.1 - 1.1e-19 70.5 0.2 7e-10 38.2 0.1 2.6 2 1 0 2 2 2 2 Protein of unknown function (DUF1479) Peptidase_M28 PF04389.17 ADV23802.1 - 5.9e-25 88.1 0.1 9.9e-25 87.4 0.1 1.3 1 0 0 1 1 1 1 Peptidase family M28 EamA PF00892.20 ADV23802.1 - 0.013 15.7 2.0 0.013 15.7 2.0 3.1 2 1 1 3 3 3 0 EamA-like transporter family Aminotran_1_2 PF00155.21 ADV23802.1 - 0.015 14.5 0.0 0.024 13.8 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class I and II Peptidase_M20 PF01546.28 ADV23802.1 - 0.031 14.0 0.0 0.066 12.9 0.0 1.4 1 1 0 1 1 1 0 Peptidase family M20/M25/M40 IGPS PF00218.21 ADV23803.1 - 9.8e-87 290.3 0.0 1.9e-86 289.4 0.0 1.5 1 0 0 1 1 1 1 Indole-3-glycerol phosphate synthase PRAI PF00697.22 ADV23803.1 - 2.4e-44 151.4 0.0 5.9e-39 133.9 0.0 2.4 1 1 1 2 2 2 2 N-(5'phosphoribosyl)anthranilate (PRA) isomerase GATase PF00117.28 ADV23803.1 - 7.6e-38 130.2 0.0 1.2e-37 129.6 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 ADV23803.1 - 2.4e-05 24.2 0.4 9.7e-05 22.2 0.4 1.9 1 1 0 1 1 1 1 Peptidase C26 His_biosynth PF00977.21 ADV23803.1 - 0.00026 20.5 0.8 0.0096 15.4 0.0 2.5 3 0 0 3 3 3 1 Histidine biosynthesis protein YjeF_N PF03853.15 ADV23803.1 - 0.021 14.7 0.0 0.55 10.1 0.0 2.3 2 0 0 2 2 2 0 YjeF-related protein N-terminus FMN_dh PF01070.18 ADV23803.1 - 0.028 13.5 1.4 0.073 12.1 0.5 2.1 2 1 0 2 2 2 0 FMN-dependent dehydrogenase TMP-TENI PF02581.17 ADV23803.1 - 0.033 13.5 0.3 4.7 6.5 0.0 2.7 2 1 1 3 3 3 0 Thiamine monophosphate synthase QRPTase_C PF01729.19 ADV23803.1 - 0.043 13.6 0.1 0.12 12.1 0.1 1.7 1 0 0 1 1 1 0 Quinolinate phosphoribosyl transferase, C-terminal domain NMO PF03060.15 ADV23803.1 - 0.88 8.9 3.9 2.4 7.5 0.0 2.8 3 0 0 3 3 3 0 Nitronate monooxygenase Clathrin_lg_ch PF01086.17 ADV23804.1 - 1.6e-42 146.2 4.4 4.1e-42 144.8 4.4 1.7 1 1 0 1 1 1 1 Clathrin light chain DUF3144 PF11342.8 ADV23804.1 - 0.0073 16.6 0.9 0.38 11.1 2.4 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF3144) YtxH PF12732.7 ADV23804.1 - 0.13 12.8 4.4 0.26 11.8 4.4 1.4 1 0 0 1 1 1 0 YtxH-like protein Glyco_hydro_92 PF07971.12 ADV23805.1 - 2.2e-132 442.3 0.6 2.8e-132 441.9 0.6 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 ADV23805.1 - 1.4e-54 185.5 0.1 2e-54 185.0 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain UCH PF00443.29 ADV23806.1 - 1.9e-26 93.1 0.1 3.4e-26 92.3 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ADV23806.1 - 2.6e-11 43.7 1.6 7.4e-10 38.9 1.6 2.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 ADV23806.1 - 0.022 14.5 0.1 0.068 12.9 0.1 1.8 1 0 0 1 1 1 0 Ubiquitin family DUSP PF06337.12 ADV23806.1 - 0.029 15.0 2.6 0.37 11.4 0.3 3.3 2 1 0 2 2 2 0 DUSP domain Ubiquitin_2 PF14560.6 ADV23806.1 - 0.13 12.8 0.3 0.26 11.8 0.3 1.4 1 0 0 1 1 1 0 Ubiquitin-like domain DZR PF12773.7 ADV23806.1 - 1.3 9.1 8.8 2.6 8.2 1.9 4.0 4 0 0 4 4 4 0 Double zinc ribbon PseudoU_synth_1 PF01416.20 ADV23807.1 - 2e-24 86.1 0.0 4.1e-24 85.1 0.0 1.5 1 0 0 1 1 1 1 tRNA pseudouridine synthase DUF5345 PF17280.2 ADV23807.1 - 0.12 12.4 0.4 0.29 11.1 0.4 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5345) DUF1769 PF08588.10 ADV23808.1 - 3.4e-23 81.6 0.4 1.3e-22 79.8 0.1 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1769) MT-A70 PF05063.14 ADV23809.1 - 1.6e-35 122.6 0.0 2.2e-35 122.1 0.0 1.1 1 0 0 1 1 1 1 MT-A70 AMP-binding PF00501.28 ADV23810.1 - 2.5e-88 296.5 0.0 3.3e-88 296.1 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Vpu PF00558.19 ADV23812.1 - 0.018 14.8 0.1 0.037 13.8 0.1 1.4 1 0 0 1 1 1 0 Vpu protein OSTbeta PF15048.6 ADV23812.1 - 0.15 12.2 0.1 5 7.3 0.0 2.3 2 0 0 2 2 2 0 Organic solute transporter subunit beta protein LapA_dom PF06305.11 ADV23812.1 - 0.16 11.8 0.2 0.29 11.0 0.2 1.3 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain DUF2064 PF09837.9 ADV23813.1 - 0.018 14.9 2.5 12 5.8 0.1 4.1 2 1 3 5 5 5 0 Uncharacterized protein conserved in bacteria (DUF2064) Peptidase_S9 PF00326.21 ADV23814.1 - 2.7e-54 183.9 0.1 4.7e-54 183.1 0.1 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family AXE1 PF05448.12 ADV23814.1 - 0.02 13.6 0.0 0.53 8.9 0.0 2.1 1 1 0 1 1 1 0 Acetyl xylan esterase (AXE1) MFS_1 PF07690.16 ADV23816.1 - 3e-16 59.3 43.3 4.5e-16 58.7 43.3 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily CDP-OH_P_tran_2 PF08009.11 ADV23816.1 - 0.038 13.9 1.3 0.038 13.9 1.3 2.6 2 1 0 2 2 2 0 CDP-alcohol phosphatidyltransferase 2 Aldedh PF00171.22 ADV23817.1 - 1.9e-162 541.0 0.0 2.1e-162 540.8 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family UPF0061 PF02696.14 ADV23818.1 - 4.5e-85 286.2 0.0 7.4e-85 285.5 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized ACR, YdiU/UPF0061 family MIT PF04212.18 ADV23820.1 - 0.0066 16.5 0.2 0.013 15.5 0.2 1.5 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain F-box PF00646.33 ADV23820.1 - 0.071 13.0 0.7 0.24 11.3 0.2 2.2 2 0 0 2 2 2 0 F-box domain F-box-like PF12937.7 ADV23820.1 - 0.16 11.9 2.8 0.4 10.6 2.8 1.8 1 0 0 1 1 1 0 F-box-like AAA_11 PF13086.6 ADV23821.1 - 7.3e-64 216.1 0.0 1.3e-63 215.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_12 PF13087.6 ADV23821.1 - 1.4e-52 178.2 0.0 2.2e-52 177.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 ADV23821.1 - 7e-09 36.2 0.0 2.3e-07 31.2 0.0 3.1 3 1 0 3 3 3 1 AAA domain AAA_30 PF13604.6 ADV23821.1 - 1.1e-07 31.8 0.0 0.00023 20.9 0.0 2.8 3 0 0 3 3 3 2 AAA domain Viral_helicase1 PF01443.18 ADV23821.1 - 4.1e-07 30.0 0.0 0.011 15.5 0.0 3.3 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase UvrD-helicase PF00580.21 ADV23821.1 - 3.2e-05 23.6 0.0 0.00013 21.6 0.0 2.2 2 1 0 2 2 2 1 UvrD/REP helicase N-terminal domain DEAD PF00270.29 ADV23821.1 - 0.00013 21.8 0.0 0.0032 17.2 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 ADV23821.1 - 0.00013 22.0 0.0 0.0018 18.3 0.0 2.3 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 ADV23821.1 - 0.0013 19.0 0.0 0.0065 16.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain DUF2075 PF09848.9 ADV23821.1 - 0.0035 16.7 0.1 0.52 9.5 0.0 2.5 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) PhoH PF02562.16 ADV23821.1 - 0.0059 16.1 0.0 0.1 12.0 0.0 2.3 2 0 0 2 2 2 1 PhoH-like protein UvrD_C_2 PF13538.6 ADV23821.1 - 0.016 15.1 0.0 0.037 13.9 0.0 1.6 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain AAA PF00004.29 ADV23821.1 - 0.019 15.4 0.3 0.26 11.7 0.1 2.5 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 ADV23821.1 - 0.021 14.4 0.0 0.22 11.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 ADV23821.1 - 0.035 14.6 0.0 0.11 13.0 0.0 1.8 1 0 0 1 1 1 0 ABC transporter AAA_24 PF13479.6 ADV23821.1 - 0.078 12.7 0.0 1.2 8.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 ADV23821.1 - 0.092 13.1 0.0 0.25 11.7 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain Helicase_RecD PF05127.14 ADV23821.1 - 0.093 12.6 0.0 1.7 8.5 0.0 2.4 2 0 0 2 2 2 0 Helicase AAA_23 PF13476.6 ADV23821.1 - 0.1 13.1 0.1 0.3 11.6 0.1 1.9 1 1 0 1 1 1 0 AAA domain DUF1712 PF08217.11 ADV23822.1 - 6.7e-14 51.3 0.0 2e-13 49.7 0.0 1.7 2 0 0 2 2 2 1 Fungal domain of unknown function (DUF1712) PAP2_3 PF14378.6 ADV23823.1 - 5e-22 78.5 14.7 5e-22 78.5 14.7 2.0 2 0 0 2 2 2 1 PAP2 superfamily PAP2 PF01569.21 ADV23823.1 - 1e-08 35.0 6.3 1e-08 35.0 6.3 2.4 3 1 0 3 3 3 1 PAP2 superfamily POP1 PF06978.11 ADV23824.1 - 1.5e-47 162.3 19.2 9.7e-25 87.8 5.6 2.3 1 1 1 2 2 2 2 Ribonucleases P/MRP protein subunit POP1 POPLD PF08170.12 ADV23824.1 - 3.5e-24 85.0 0.1 6.8e-24 84.0 0.1 1.5 1 0 0 1 1 1 1 POPLD (NUC188) domain GCV_T PF01571.21 ADV23824.1 - 0.0002 20.8 0.0 0.56 9.5 0.0 3.1 3 0 0 3 3 3 2 Aminomethyltransferase folate-binding domain SNF2_N PF00176.23 ADV23825.1 - 1.5e-61 208.0 0.7 2.5e-61 207.3 0.7 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain DUF4208 PF13907.6 ADV23825.1 - 7e-26 90.5 0.2 2.7e-25 88.6 0.2 2.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4208) Helicase_C PF00271.31 ADV23825.1 - 6e-18 65.2 0.0 1.9e-17 63.6 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Chromo PF00385.24 ADV23825.1 - 2.6e-17 62.5 9.0 7.8e-14 51.3 2.0 2.9 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain ResIII PF04851.15 ADV23825.1 - 7.8e-09 35.8 0.0 2.4e-08 34.2 0.0 1.9 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Myb_DNA-binding PF00249.31 ADV23825.1 - 0.00041 20.5 0.3 0.0014 18.8 0.3 2.0 1 0 0 1 1 1 1 Myb-like DNA-binding domain CHDCT2 PF08074.11 ADV23825.1 - 0.0007 19.8 0.1 0.073 13.2 0.0 3.3 2 1 0 2 2 2 1 CHDCT2 (NUC038) domain Cdh1_DBD_1 PF18196.1 ADV23825.1 - 0.0024 18.2 0.1 0.0024 18.2 0.1 6.3 6 1 1 7 7 7 2 Chromodomain helicase DNA-binding domain 1 ERCC3_RAD25_C PF16203.5 ADV23825.1 - 0.0051 16.1 0.6 0.0094 15.2 0.0 1.7 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase Gly_transf_sug PF04488.15 ADV23826.1 - 9.4e-06 26.2 0.0 2.1e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Ribosomal_S28e PF01200.18 ADV23826.1 - 0.013 15.5 0.0 0.025 14.6 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein S28e Ribosomal_L19e PF01280.20 ADV23827.1 - 6.6e-61 204.6 10.2 6.6e-61 204.6 10.2 1.8 1 1 1 2 2 2 1 Ribosomal protein L19e S4 PF01479.25 ADV23827.1 - 0.052 13.3 0.0 0.15 11.8 0.0 1.8 1 0 0 1 1 1 0 S4 domain Methyltransf_23 PF13489.6 ADV23828.1 - 2.5e-05 24.2 0.0 3.4e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ADV23828.1 - 0.00032 21.4 0.0 0.0011 19.7 0.0 1.9 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 ADV23828.1 - 0.058 14.0 0.0 0.099 13.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain SF3b1 PF08920.10 ADV23829.1 - 3.9e-14 53.2 8.7 3.9e-14 53.2 8.7 3.5 1 1 1 2 2 2 1 Splicing factor 3B subunit 1 HEAT_EZ PF13513.6 ADV23829.1 - 2.1e-12 47.2 11.1 0.019 15.5 0.0 9.0 8 2 3 11 11 11 4 HEAT-like repeat HEAT_2 PF13646.6 ADV23829.1 - 1.3e-11 44.7 12.4 0.00095 19.5 0.1 8.4 5 2 3 9 9 9 3 HEAT repeats Vac14_Fab1_bd PF12755.7 ADV23829.1 - 1.1e-09 38.8 0.7 0.043 14.4 0.0 5.4 5 0 0 5 5 5 3 Vacuolar 14 Fab1-binding region HEAT PF02985.22 ADV23829.1 - 8.5e-08 31.8 13.3 0.21 12.0 0.1 10.7 14 0 0 14 14 12 1 HEAT repeat Adaptin_N PF01602.20 ADV23829.1 - 9.3e-08 31.1 0.6 0.017 13.7 0.0 3.3 3 0 0 3 3 3 2 Adaptin N terminal region CLASP_N PF12348.8 ADV23829.1 - 0.0015 18.2 0.2 0.63 9.6 0.0 2.8 2 0 0 2 2 2 2 CLASP N terminal Cnd1 PF12717.7 ADV23829.1 - 0.0016 18.5 8.2 1.4 8.9 0.0 5.7 8 0 0 8 8 8 1 non-SMC mitotic condensation complex subunit 1 DUF3385 PF11865.8 ADV23829.1 - 0.0017 18.3 1.0 1.6 8.6 0.1 4.4 4 1 0 4 4 4 1 Domain of unknown function (DUF3385) MMS19_C PF12460.8 ADV23829.1 - 0.0027 16.9 0.0 0.074 12.2 0.0 3.2 4 0 0 4 4 4 1 RNAPII transcription regulator C-terminal NUC173 PF08161.12 ADV23829.1 - 0.0046 16.6 0.8 0.38 10.4 0.0 4.0 5 1 1 6 6 6 1 NUC173 domain RPA_C PF08784.11 ADV23829.1 - 0.014 16.1 0.0 1.3 9.7 0.0 2.7 2 0 0 2 2 2 0 Replication protein A C terminal TIP120 PF08623.10 ADV23829.1 - 0.075 12.8 0.6 0.92 9.3 0.0 3.0 4 0 0 4 4 4 0 TATA-binding protein interacting (TIP20) DLH PF01738.18 ADV23830.1 - 4.1e-19 69.0 0.0 5.2e-19 68.7 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family RRM_1 PF00076.22 ADV23832.1 - 9.6e-79 259.2 0.7 3e-19 68.6 0.2 4.2 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 ADV23832.1 - 4e-29 100.6 0.9 1.3e-28 98.9 1.0 1.8 2 0 0 2 2 2 1 Poly-adenylate binding protein, unique domain RRM_5 PF13893.6 ADV23832.1 - 3.7e-09 36.2 0.0 0.00032 20.3 0.0 4.1 2 2 2 4 4 4 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 ADV23832.1 - 0.0011 18.9 0.0 1.3 9.1 0.0 3.9 4 0 0 4 4 4 1 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 ADV23832.1 - 0.0025 17.9 0.1 20 5.4 0.0 4.1 4 1 0 4 4 4 0 RNA recognition motif YflT PF11181.8 ADV23832.1 - 0.0026 18.2 1.5 3.6 8.1 2.0 2.9 2 0 0 2 2 2 2 Heat induced stress protein YflT DUF1318 PF07027.12 ADV23832.1 - 0.017 15.5 1.7 4.3 7.8 0.6 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1318) RRM_occluded PF16842.5 ADV23832.1 - 0.023 14.5 0.0 1.8 8.5 0.0 2.9 3 0 0 3 3 3 0 Occluded RNA-recognition motif Limkain-b1 PF11608.8 ADV23832.1 - 0.1 12.7 2.8 10 6.3 0.1 4.0 3 1 1 4 4 4 0 Limkain b1 OB_RNB PF08206.11 ADV23832.1 - 0.12 12.1 0.6 19 5.0 0.1 3.4 3 0 0 3 3 3 0 Ribonuclease B OB domain DUF4407 PF14362.6 ADV23832.1 - 0.15 11.4 0.5 0.3 10.4 0.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ATP-synt_ab PF00006.25 ADV23833.1 - 1.1e-67 227.8 0.0 1.5e-67 227.3 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 ADV23833.1 - 4.6e-11 43.1 0.3 8.4e-11 42.2 0.3 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain AAA_18 PF13238.6 ADV23834.1 - 8.2e-06 26.4 0.4 9.3e-05 23.0 0.4 2.0 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 ADV23834.1 - 0.0028 17.8 0.0 0.013 15.7 0.0 2.0 2 1 0 2 2 2 1 AAA domain PRK PF00485.18 ADV23834.1 - 0.0031 17.3 0.2 0.0082 15.9 0.2 1.7 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family Ferric_reduct PF01794.19 ADV23835.1 - 1.3e-17 64.0 14.8 1.3e-17 64.0 14.8 1.8 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 ADV23835.1 - 4.4e-16 59.4 0.0 6.6e-12 45.8 0.0 2.3 2 0 0 2 2 2 2 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 ADV23835.1 - 7.6e-14 51.7 0.0 1.8e-13 50.5 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain Pkinase PF00069.25 ADV23836.1 - 1.6e-47 162.1 0.0 2.4e-47 161.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV23836.1 - 6.1e-15 55.2 0.2 1.2e-14 54.2 0.2 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ADV23836.1 - 0.026 14.4 0.0 0.06 13.3 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family RIO1 PF01163.22 ADV23836.1 - 0.11 12.1 0.1 0.21 11.2 0.1 1.4 1 0 0 1 1 1 0 RIO1 family Atx10homo_assoc PF09759.9 ADV23837.1 - 0.079 13.0 0.1 11 6.1 0.0 2.7 2 0 0 2 2 2 0 Spinocerebellar ataxia type 10 protein domain RCC1 PF00415.18 ADV23839.1 - 0.079 13.6 0.1 1.4 9.6 0.0 2.9 3 0 0 3 3 3 0 Regulator of chromosome condensation (RCC1) repeat MCM_bind PF09739.9 ADV23840.1 - 2e-56 191.7 0.0 2.7e-52 178.1 0.0 3.7 1 1 1 3 3 3 3 Mini-chromosome maintenance replisome factor TPK_catalytic PF04263.16 ADV23841.1 - 1.4e-30 105.8 0.1 1.9e-30 105.4 0.1 1.2 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.14 ADV23841.1 - 6.4e-16 57.8 0.1 1e-15 57.2 0.1 1.3 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain Ribosomal_S7e PF01251.18 ADV23842.1 - 2.6e-83 278.3 4.3 2.9e-83 278.1 4.3 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e BatA PF07584.11 ADV23843.1 - 0.18 12.2 1.0 1.9 8.9 0.0 3.0 3 0 0 3 3 3 0 Aerotolerance regulator N-terminal Ribosomal_S18 PF01084.20 ADV23844.1 - 2.3e-10 40.5 0.0 3.6e-10 39.9 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S18 Tim17 PF02466.19 ADV23845.1 - 3e-10 40.4 0.0 5e-10 39.7 0.0 1.3 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Zn_clus PF00172.18 ADV23846.1 - 2.9e-07 30.5 8.9 2.9e-07 30.5 8.9 2.4 3 0 0 3 3 3 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Actin PF00022.19 ADV23848.1 - 6.1e-15 54.7 0.0 2.8e-13 49.3 0.0 2.3 2 1 0 2 2 2 2 Actin Phage_holin_7_1 PF16081.5 ADV23848.1 - 0.042 14.0 3.8 0.079 13.1 3.8 1.4 1 0 0 1 1 1 0 Mycobacterial 2 TMS Phage Holin (M2 Hol) Family Sec63 PF02889.16 ADV23849.1 - 4.1e-27 95.0 0.0 6e-27 94.4 0.0 1.3 1 0 0 1 1 1 1 Sec63 Brl domain DEAD PF00270.29 ADV23849.1 - 2.9e-24 85.8 0.0 5.1e-23 81.7 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ADV23849.1 - 1e-10 41.9 0.0 7e-10 39.2 0.0 2.4 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 ADV23849.1 - 1.1e-09 38.5 0.0 2.1e-09 37.6 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit UvrD-helicase PF00580.21 ADV23849.1 - 0.0066 16.0 0.0 4.7 6.6 0.0 3.9 4 0 0 4 4 4 1 UvrD/REP helicase N-terminal domain AAA_22 PF13401.6 ADV23849.1 - 0.011 16.0 0.1 0.072 13.4 0.0 2.3 2 1 0 2 2 2 0 AAA domain T2SSE PF00437.20 ADV23849.1 - 0.062 12.4 0.0 0.12 11.4 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA PF00004.29 ADV23849.1 - 0.099 13.1 0.1 0.46 10.9 0.2 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Yqai PF09466.10 ADV23849.1 - 0.12 12.7 0.5 3.2 8.1 0.1 3.2 3 0 0 3 3 3 0 Hypothetical protein Yqai AAA_19 PF13245.6 ADV23849.1 - 0.17 12.2 0.0 1.2 9.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain Med10 PF09748.9 ADV23850.1 - 1.5e-18 66.9 0.3 2.1e-18 66.4 0.3 1.1 1 0 0 1 1 1 1 Transcription factor subunit Med10 of Mediator complex LUC7 PF03194.15 ADV23851.1 - 7.2e-61 206.0 0.5 7.2e-61 206.0 0.5 1.8 2 0 0 2 2 2 1 LUC7 N_terminus VIR_N PF15912.5 ADV23851.1 - 4.7 6.7 11.2 11 5.6 11.2 1.6 1 0 0 1 1 1 0 Virilizer, N-terminal His_Phos_1 PF00300.22 ADV23852.1 - 1.7e-11 44.2 1.0 1.4e-10 41.2 1.0 2.0 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) 2OG-FeII_Oxy PF03171.20 ADV23852.1 - 0.12 12.9 0.0 0.22 12.0 0.0 1.4 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Plant_all_beta PF10532.9 ADV23853.1 - 0.037 14.3 0.4 0.046 14.0 0.4 1.2 1 0 0 1 1 1 0 Plant specific N-all beta domain Nnf1 PF03980.14 ADV23854.1 - 1.1e-05 25.7 0.1 3.1e-05 24.3 0.1 1.8 1 0 0 1 1 1 1 Nnf1 ATG16 PF08614.11 ADV23854.1 - 0.092 13.0 0.2 0.092 13.0 0.2 2.9 3 1 0 3 3 3 0 Autophagy protein 16 (ATG16) LRR_4 PF12799.7 ADV23855.1 - 3.6e-12 46.3 13.0 3.5e-08 33.6 4.6 5.2 4 1 1 5 5 5 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ADV23855.1 - 1e-10 41.2 29.0 7.4e-08 32.0 8.7 3.5 2 1 4 6 6 6 4 Leucine rich repeat LRR_6 PF13516.6 ADV23855.1 - 0.018 15.1 13.1 1.4 9.2 2.6 4.5 4 0 0 4 4 4 0 Leucine Rich repeat LRR_1 PF00560.33 ADV23855.1 - 7.9 7.5 20.5 2.7 8.9 0.3 5.7 7 0 0 7 7 7 0 Leucine Rich Repeat Uso1_p115_head PF04869.14 ADV23856.1 - 8.1e-73 245.3 0.0 2e-72 244.0 0.0 1.7 1 1 0 1 1 1 1 Uso1 / p115 like vesicle tethering protein, head region Uso1_p115_C PF04871.13 ADV23856.1 - 2e-09 37.9 28.0 2e-09 37.9 28.0 4.8 1 1 3 4 4 4 2 Uso1 / p115 like vesicle tethering protein, C terminal region Spc7 PF08317.11 ADV23856.1 - 8.8e-05 21.5 21.4 8.8e-05 21.5 21.4 3.9 2 2 2 4 4 3 2 Spc7 kinetochore protein Arm_vescicular PF18770.1 ADV23856.1 - 0.0013 18.6 0.0 0.0049 16.8 0.0 2.0 1 0 0 1 1 1 1 Armadillo tether-repeat of vescicular transport factor TMF_DNA_bd PF12329.8 ADV23856.1 - 0.0097 15.9 5.8 0.0097 15.9 5.8 6.7 4 2 2 6 6 5 2 TATA element modulatory factor 1 DNA binding Tropomyosin PF00261.20 ADV23856.1 - 0.71 9.2 79.8 1.6 8.0 8.7 3.0 1 1 1 2 2 2 0 Tropomyosin Fez1 PF06818.15 ADV23856.1 - 0.82 10.1 69.5 1.1 9.7 19.6 2.7 2 1 0 2 2 2 0 Fez1 Baculo_PEP_C PF04513.12 ADV23856.1 - 1.5 8.9 11.0 1.7 8.7 6.6 3.2 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus ATG16 PF08614.11 ADV23856.1 - 3.1 8.0 81.5 4.3 7.5 18.9 5.1 2 1 2 4 4 4 0 Autophagy protein 16 (ATG16) NPV_P10 PF05531.12 ADV23856.1 - 3.2 8.3 17.7 17 6.0 1.6 4.9 3 1 0 4 4 4 0 Nucleopolyhedrovirus P10 protein MerR-DNA-bind PF09278.11 ADV23856.1 - 5 7.7 6.7 26 5.5 0.5 3.8 4 0 0 4 4 4 0 MerR, DNA binding adh_short PF00106.25 ADV23858.1 - 7e-36 123.5 0.2 9.5e-36 123.1 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ADV23858.1 - 1.6e-21 77.0 0.0 2.5e-21 76.3 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ADV23858.1 - 4.1e-05 23.6 0.2 0.00011 22.2 0.2 1.9 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 ADV23858.1 - 0.0087 15.2 0.1 0.012 14.8 0.1 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 ADV23858.1 - 0.095 12.6 0.0 0.14 12.0 0.0 1.5 1 1 0 1 1 1 0 NAD(P)H-binding PTH2 PF01981.16 ADV23859.1 - 1.4e-13 51.1 0.0 1.9e-13 50.7 0.0 1.1 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 Acetyltransf_18 PF18014.1 ADV23859.1 - 0.079 12.8 0.0 0.32 10.9 0.0 1.8 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain zf-U1 PF06220.12 ADV23861.1 - 1.3e-19 69.6 4.9 2.2e-19 68.9 4.9 1.3 1 0 0 1 1 1 1 U1 zinc finger Trypan_PARP PF05887.11 ADV23862.1 - 0.2 11.7 13.0 0.14 12.2 11.3 1.7 1 1 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Suf PF05843.14 ADV23862.1 - 0.59 10.1 4.8 0.77 9.7 4.8 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Presenilin PF01080.17 ADV23862.1 - 1.2 7.9 5.5 1.4 7.6 5.5 1.1 1 0 0 1 1 1 0 Presenilin Apt1 PF10351.9 ADV23862.1 - 1.6 7.5 6.5 2 7.1 6.5 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain RR_TM4-6 PF06459.12 ADV23862.1 - 6.7 6.4 10.6 9.4 6.0 10.6 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RabGAP-TBC PF00566.18 ADV23863.1 - 1.5e-38 132.6 0.0 2.1e-38 132.2 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain SH3_2 PF07653.17 ADV23863.1 - 0.045 13.4 0.0 0.13 12.0 0.0 1.8 1 0 0 1 1 1 0 Variant SH3 domain GCR1_C PF12550.8 ADV23864.1 - 1.7e-22 79.5 1.6 3.2e-22 78.6 1.0 1.8 2 0 0 2 2 2 1 Transcriptional activator of glycolytic enzymes SPX PF03105.19 ADV23864.1 - 0.006 16.5 2.9 0.006 16.5 2.9 1.9 1 1 1 2 2 2 1 SPX domain PI3K_1B_p101 PF10486.9 ADV23865.1 - 0.65 7.7 2.4 0.62 7.8 0.4 1.8 2 0 0 2 2 2 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Spt20 PF12090.8 ADV23870.1 - 7.3e-20 71.6 7.0 3.9e-13 49.6 0.0 3.1 2 1 1 3 3 3 2 Spt20 family RR_TM4-6 PF06459.12 ADV23870.1 - 2.5 7.9 11.1 3.1 7.6 11.1 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Pkinase PF00069.25 ADV23871.1 - 2.5e-66 223.8 0.0 3e-66 223.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV23871.1 - 6.4e-28 97.7 0.0 8.3e-28 97.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 ADV23871.1 - 0.002 17.1 0.0 0.0029 16.6 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 ADV23871.1 - 0.02 14.2 0.0 0.033 13.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ADV23871.1 - 0.048 13.6 0.2 0.19 11.7 0.1 1.8 1 1 0 2 2 2 0 Phosphotransferase enzyme family WD40 PF00400.32 ADV23871.1 - 0.16 12.9 0.0 0.43 11.5 0.0 1.7 1 0 0 1 1 1 0 WD domain, G-beta repeat Aldo_ket_red PF00248.21 ADV23873.1 - 9.1e-42 143.2 0.0 4.8e-40 137.6 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family Antimicrobial18 PF08130.11 ADV23873.1 - 0.21 11.7 0.0 0.44 10.7 0.0 1.5 1 0 0 1 1 1 0 Type A lantibiotic family MFS_1 PF07690.16 ADV23874.1 - 2.4e-38 132.0 51.1 2.9e-29 102.1 28.9 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ADV23874.1 - 5.5e-12 45.3 14.4 5.5e-12 45.3 14.4 3.2 2 1 1 3 3 3 1 Sugar (and other) transporter WD40 PF00400.32 ADV23876.1 - 7.2e-10 39.3 4.8 0.0056 17.5 0.1 6.3 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV23876.1 - 0.00075 19.8 0.0 19 5.6 0.0 4.2 3 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 ADV23876.1 - 0.065 11.8 0.0 0.1 11.1 0.0 1.2 1 0 0 1 1 1 0 Cytochrome D1 heme domain Choline_kinase PF01633.20 ADV23877.1 - 2.1e-53 181.1 0.0 3e-53 180.6 0.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 ADV23877.1 - 3.1e-10 40.4 0.1 5.2e-10 39.6 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family WD40 PF00400.32 ADV23878.1 - 7.1e-12 45.7 13.1 0.025 15.5 0.2 7.7 7 0 0 7 7 7 2 WD domain, G-beta repeat DHHA1 PF02272.19 ADV23878.1 - 0.00061 20.2 0.4 0.0081 16.6 0.0 2.3 2 0 0 2 2 2 1 DHHA1 domain APG6_N PF17675.1 ADV23878.1 - 4.5 7.8 14.0 0.4 11.2 3.8 2.3 2 0 0 2 2 2 0 Apg6 coiled-coil region NAM-associated PF14303.6 ADV23878.1 - 7.7 7.2 11.5 0.088 13.5 3.2 1.9 2 0 0 2 2 2 0 No apical meristem-associated C-terminal domain Cyclin_C_2 PF16899.5 ADV23879.1 - 4.5e-14 52.7 0.1 1.5e-12 47.8 0.0 2.8 3 0 0 3 3 3 1 Cyclin C-terminal domain Cyclin_N PF00134.23 ADV23879.1 - 1.7e-08 34.2 0.0 3.3e-08 33.3 0.0 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain TFIIB PF00382.19 ADV23879.1 - 0.0022 18.0 0.0 0.03 14.4 0.0 2.7 3 0 0 3 3 3 1 Transcription factor TFIIB repeat zf-CCCH PF00642.24 ADV23880.1 - 2.1e-06 27.5 31.9 0.026 14.5 1.9 5.8 5 1 0 5 5 5 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 ADV23880.1 - 4.2e-06 27.4 12.2 0.11 13.2 0.1 4.7 1 1 2 4 4 4 3 Torus domain zf-CCCH_4 PF18044.1 ADV23880.1 - 0.00072 19.3 24.4 0.012 15.3 1.2 4.0 5 0 0 5 5 5 3 CCCH-type zinc finger zf-CCCH_3 PF15663.5 ADV23880.1 - 0.0017 18.6 10.2 0.022 15.0 1.0 3.2 1 1 2 3 3 3 2 Zinc-finger containing family zf_CCCH_4 PF18345.1 ADV23880.1 - 0.0032 17.5 29.3 0.013 15.5 0.5 5.2 6 0 0 6 6 6 3 Zinc finger domain NOA36 PF06524.12 ADV23880.1 - 0.0037 16.6 12.5 0.0058 16.0 12.5 1.3 1 0 0 1 1 1 1 NOA36 protein RXT2_N PF08595.11 ADV23880.1 - 0.77 9.8 7.4 1.6 8.7 7.4 1.6 1 0 0 1 1 1 0 RXT2-like, N-terminal Pox_Ag35 PF03286.14 ADV23880.1 - 0.78 9.5 15.2 1.5 8.6 15.2 1.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein CDC45 PF02724.14 ADV23880.1 - 3.6 5.8 20.1 5.5 5.2 20.1 1.2 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 ADV23880.1 - 5.2 6.4 23.4 8.9 5.6 23.4 1.4 1 0 0 1 1 1 0 SDA1 DUF5523 PF17661.1 ADV23880.1 - 5.5 6.6 14.4 8.2 6.0 14.4 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5523) Nop14 PF04147.12 ADV23880.1 - 9.5 4.3 27.2 13 3.8 27.2 1.1 1 0 0 1 1 1 0 Nop14-like family SNAP PF14938.6 ADV23881.1 - 4.1e-100 334.9 20.8 4.6e-100 334.7 20.8 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_6 PF13174.6 ADV23881.1 - 0.043 14.5 9.2 2.6 8.9 0.0 5.3 3 2 2 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.6 ADV23881.1 - 0.063 13.3 5.5 4.1 7.7 0.1 4.9 2 2 2 4 4 4 0 Tetratricopeptide repeat DHR-2 PF06920.13 ADV23881.1 - 0.094 11.3 1.7 0.52 8.9 0.2 2.3 1 1 2 3 3 3 0 Dock homology region 2 TPR_8 PF13181.6 ADV23881.1 - 0.18 12.1 4.2 2 8.8 0.1 4.3 3 2 1 4 4 4 0 Tetratricopeptide repeat Spatacsin_C PF14649.6 ADV23881.1 - 3.4 6.7 9.9 4.5 6.3 0.4 2.9 1 1 1 3 3 3 0 Spatacsin C-terminus TPR_11 PF13414.6 ADV23881.1 - 4.7 7.0 12.0 15 5.4 1.1 5.1 4 3 1 5 5 5 0 TPR repeat Ala_racemase_N PF01168.20 ADV23882.1 - 7.4e-17 61.7 0.0 1.2e-16 61.0 0.0 1.4 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain TRAUB PF08164.12 ADV23884.1 - 1.9e-22 79.6 0.0 6.1e-22 77.9 0.0 1.9 1 0 0 1 1 1 1 Apoptosis-antagonizing transcription factor, C-terminal AATF-Che1 PF13339.6 ADV23884.1 - 2.2e-19 70.5 0.3 2.2e-19 70.5 0.3 2.7 3 0 0 3 3 3 1 Apoptosis antagonizing transcription factor Nop14 PF04147.12 ADV23884.1 - 3.4e-05 22.3 14.3 4.7e-05 21.8 14.3 1.3 1 0 0 1 1 1 1 Nop14-like family SDA1 PF05285.12 ADV23884.1 - 0.00017 21.1 14.2 0.00017 21.1 14.2 1.9 2 0 0 2 2 2 1 SDA1 CDC45 PF02724.14 ADV23884.1 - 0.00026 19.5 10.7 0.00042 18.8 10.7 1.4 1 0 0 1 1 1 1 CDC45-like protein Mpp10 PF04006.12 ADV23884.1 - 0.0013 17.3 13.3 0.0013 17.3 13.3 1.6 2 0 0 2 2 2 1 Mpp10 protein RRN3 PF05327.11 ADV23884.1 - 0.099 11.2 16.5 0.15 10.5 16.5 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 PPP4R2 PF09184.11 ADV23884.1 - 0.23 11.0 17.7 0.44 10.1 17.7 1.5 1 0 0 1 1 1 0 PPP4R2 DNA_pol_phi PF04931.13 ADV23884.1 - 1.3 7.1 32.4 1.9 6.5 32.4 1.2 1 0 0 1 1 1 0 DNA polymerase phi DUF2151 PF10221.9 ADV23884.1 - 1.4 7.5 4.5 2.2 6.8 4.5 1.3 1 0 0 1 1 1 0 Cell cycle and development regulator Roughex PF06020.11 ADV23884.1 - 1.8 7.6 12.5 2.8 6.9 12.5 1.2 1 0 0 1 1 1 0 Drosophila roughex protein PI3K_1B_p101 PF10486.9 ADV23884.1 - 2.9 5.5 5.1 4.1 5.1 5.1 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Sec63 PF02889.16 ADV23885.1 - 8.4e-72 241.4 0.6 1.2e-71 240.9 0.6 1.3 1 0 0 1 1 1 1 Sec63 Brl domain DEAD PF00270.29 ADV23885.1 - 7.2e-37 126.8 0.2 1e-25 90.5 0.4 2.5 2 0 0 2 2 2 2 DEAD/DEAH box helicase ResIII PF04851.15 ADV23885.1 - 3.6e-19 69.4 0.0 3.1e-12 46.8 0.0 2.5 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 ADV23885.1 - 1.6e-07 31.7 0.0 9.3e-06 26.0 0.0 3.6 3 1 0 3 3 3 1 Helicase conserved C-terminal domain AAA_19 PF13245.6 ADV23885.1 - 0.00023 21.5 1.3 0.3 11.4 0.2 2.9 3 0 0 3 3 2 2 AAA domain AAA_11 PF13086.6 ADV23885.1 - 0.00026 20.9 0.4 0.12 12.2 0.0 3.1 2 1 1 3 3 3 1 AAA domain AAA_22 PF13401.6 ADV23885.1 - 0.0028 17.9 2.3 1.1 9.5 0.5 3.8 2 2 0 2 2 2 1 AAA domain PhoH PF02562.16 ADV23885.1 - 0.004 16.6 0.0 3.5 7.0 0.0 2.5 2 0 0 2 2 2 2 PhoH-like protein IstB_IS21 PF01695.17 ADV23885.1 - 0.013 15.2 0.0 0.76 9.5 0.0 2.9 3 0 0 3 3 3 0 IstB-like ATP binding protein UvrD-helicase PF00580.21 ADV23885.1 - 0.029 13.9 0.1 0.48 9.9 0.1 2.4 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain AAA_16 PF13191.6 ADV23885.1 - 0.084 13.2 0.0 8.8 6.7 0.0 3.0 2 1 0 2 2 2 0 AAA ATPase domain NDC10_II PF16787.5 ADV23886.1 - 1.2e-09 37.6 0.0 1.9e-09 37.0 0.0 1.2 1 0 0 1 1 1 1 Centromere DNA-binding protein complex CBF3 subunit, domain 2 DNA_pol_B_palm PF14792.6 ADV23887.1 - 1.5e-32 112.2 0.0 2.9e-32 111.2 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase beta palm DNA_pol_B_thumb PF14791.6 ADV23887.1 - 1.2e-22 79.8 0.5 3.3e-22 78.4 0.5 1.8 1 0 0 1 1 1 1 DNA polymerase beta thumb DNA_pol_lambd_f PF10391.9 ADV23887.1 - 1e-14 54.1 0.1 3.2e-14 52.5 0.0 2.0 2 0 0 2 2 2 1 Fingers domain of DNA polymerase lambda PTCB-BRCT PF12738.7 ADV23887.1 - 0.0044 16.9 0.0 0.011 15.6 0.0 1.7 1 0 0 1 1 1 1 twin BRCT domain BRCT PF00533.26 ADV23887.1 - 0.013 15.9 0.0 0.037 14.4 0.0 1.7 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain DUF4633 PF15464.6 ADV23887.1 - 0.046 13.9 0.1 0.15 12.2 0.0 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4633) Cdd1 PF11731.8 ADV23887.1 - 0.048 13.9 0.0 0.14 12.4 0.0 1.8 2 0 0 2 2 2 0 Pathogenicity locus HHH_8 PF14716.6 ADV23887.1 - 0.11 12.9 0.0 0.32 11.4 0.0 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix domain Sigma70_ner PF04546.13 ADV23887.1 - 1.8 8.4 5.5 1.1 9.1 1.9 2.3 3 0 0 3 3 3 0 Sigma-70, non-essential region DIM1 PF02966.16 ADV23889.1 - 1.9e-65 218.6 0.5 2.1e-65 218.5 0.5 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin PF00085.20 ADV23889.1 - 0.01 15.8 0.0 0.013 15.5 0.0 1.1 1 0 0 1 1 1 0 Thioredoxin Glyco_hydro_79C PF16862.5 ADV23890.1 - 1.1e-16 61.5 1.5 4e-16 59.8 0.5 2.4 2 0 0 2 2 2 1 Glycosyl hydrolase family 79 C-terminal beta domain Acetyltransf_1 PF00583.25 ADV23892.1 - 7.8e-06 26.1 0.0 0.18 12.1 0.0 2.2 2 0 0 2 2 2 2 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ADV23892.1 - 1.6e-05 25.2 0.0 3.1e-05 24.3 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ADV23892.1 - 0.00049 20.0 0.0 0.001 19.0 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_4 PF13420.7 ADV23892.1 - 0.037 14.2 0.0 0.065 13.4 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ADV23892.1 - 0.046 13.7 0.0 0.55 10.2 0.0 2.2 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Ssl1 PF04056.14 ADV23893.1 - 2e-55 187.6 0.0 2.8e-55 187.1 0.0 1.1 1 0 0 1 1 1 1 Ssl1-like C1_4 PF07975.12 ADV23893.1 - 1.8e-16 60.1 9.6 1.8e-16 60.1 9.6 2.4 2 0 0 2 2 2 1 TFIIH C1-like domain VWA_2 PF13519.6 ADV23893.1 - 1.9e-10 41.3 0.0 3.4e-10 40.5 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain DUF4428 PF14471.6 ADV23893.1 - 0.14 12.1 2.7 0.41 10.6 2.7 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4428) DZR PF12773.7 ADV23893.1 - 0.55 10.3 20.1 0.48 10.5 4.4 3.1 2 1 0 2 2 2 0 Double zinc ribbon Tfb4 PF03850.14 ADV23893.1 - 0.67 9.4 3.3 4.6 6.6 4.0 1.8 2 0 0 2 2 2 0 Transcription factor Tfb4 WD40 PF00400.32 ADV23894.1 - 3.5e-05 24.5 1.2 0.36 11.8 0.0 4.6 5 0 0 5 5 5 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV23894.1 - 0.0033 17.7 0.0 8.5 6.8 0.0 3.7 1 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain PHD PF00628.29 ADV23896.1 - 1e-06 28.6 8.8 0.0002 21.2 1.6 3.4 3 0 0 3 3 3 3 PHD-finger Zn_ribbon_17 PF17120.5 ADV23896.1 - 1.4e-05 24.6 21.3 8.3e-05 22.1 3.8 3.2 2 1 1 3 3 3 2 Zinc-ribbon, C4HC2 type zf-C3HC4_2 PF13923.6 ADV23896.1 - 0.054 13.3 2.0 0.054 13.3 2.0 2.7 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) C1_2 PF03107.16 ADV23896.1 - 8.8 6.7 10.5 14 6.1 3.6 2.8 1 1 1 2 2 2 0 C1 domain polyprenyl_synt PF00348.17 ADV23897.1 - 5e-64 215.8 0.0 2.2e-57 194.1 0.0 2.1 2 0 0 2 2 2 2 Polyprenyl synthetase HEPN_SAV2148 PF18725.1 ADV23897.1 - 0.13 11.6 0.8 0.22 10.9 0.8 1.3 1 0 0 1 1 1 0 SAV2148-like HEPN Glyco_hydro_79C PF16862.5 ADV23898.1 - 1.9e-17 64.0 0.6 1.9e-17 64.0 0.6 2.5 3 0 0 3 3 3 1 Glycosyl hydrolase family 79 C-terminal beta domain Glyco_hydro_79C PF16862.5 ADV23899.1 - 3.1e-19 69.8 1.7 5.9e-19 68.9 0.4 2.2 2 0 0 2 2 2 1 Glycosyl hydrolase family 79 C-terminal beta domain Polysacc_lyase PF14099.6 ADV23900.1 - 0.037 13.9 0.1 0.07 13.0 0.1 1.4 1 0 0 1 1 1 0 Polysaccharide lyase WD40 PF00400.32 ADV23901.1 - 0.0024 18.7 2.7 12 6.9 0.0 3.7 3 0 0 3 3 3 2 WD domain, G-beta repeat PD40 PF07676.12 ADV23901.1 - 0.13 12.2 0.5 0.76 9.8 0.1 2.3 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat DUF2431 PF10354.9 ADV23902.1 - 9.6e-54 182.1 0.0 1.4e-53 181.6 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF2431) Macoilin PF09726.9 ADV23902.1 - 2.3 6.7 4.8 3.3 6.2 4.8 1.2 1 0 0 1 1 1 0 Macoilin family CBF PF03914.17 ADV23903.1 - 1.4e-54 184.7 0.0 1.4e-54 184.7 0.0 3.8 5 1 0 5 5 5 1 CBF/Mak21 family BUD22 PF09073.10 ADV23903.1 - 0.44 9.8 86.4 0.0074 15.7 45.5 3.2 3 0 0 3 3 3 0 BUD22 DUF4461 PF14688.6 ADV23904.1 - 0.00022 21.1 0.1 0.00022 21.1 0.1 1.8 2 1 0 2 2 2 1 Domain of unknown function (DUF4461) NUC205 PF08168.11 ADV23904.1 - 0.093 12.3 0.1 0.24 10.9 0.1 1.7 1 0 0 1 1 1 0 NUC205 domain Met_10 PF02475.16 ADV23905.1 - 3e-56 190.3 0.0 4.2e-56 189.9 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_25 PF13649.6 ADV23905.1 - 0.071 13.8 0.0 0.22 12.2 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain PrmA PF06325.13 ADV23905.1 - 0.13 11.6 0.0 0.23 10.8 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) ABC_membrane PF00664.23 ADV23906.1 - 5.3e-42 144.4 12.2 6.8e-42 144.0 12.2 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 ADV23906.1 - 7.8e-33 113.9 0.0 1.9e-32 112.7 0.0 1.7 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ADV23906.1 - 1.1e-05 25.0 0.0 0.0064 16.0 0.0 2.5 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 ADV23906.1 - 0.00082 19.7 0.0 0.0044 17.3 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ADV23906.1 - 0.0025 18.2 0.1 0.013 15.9 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain AAA_21 PF13304.6 ADV23906.1 - 0.0042 16.9 0.1 0.064 13.1 0.0 2.2 1 1 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system MMR_HSR1 PF01926.23 ADV23906.1 - 0.0073 16.4 0.2 0.033 14.3 0.0 2.2 3 0 0 3 3 3 1 50S ribosome-binding GTPase Rad17 PF03215.15 ADV23906.1 - 0.02 14.8 0.0 0.099 12.6 0.0 2.1 3 0 0 3 3 3 0 Rad17 P-loop domain AAA_29 PF13555.6 ADV23906.1 - 0.025 14.3 0.0 0.093 12.5 0.0 1.9 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_15 PF13175.6 ADV23906.1 - 0.048 13.4 0.0 0.096 12.4 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 ADV23906.1 - 0.067 13.1 0.1 0.23 11.3 0.0 1.9 2 0 0 2 2 2 0 RsgA GTPase AAA PF00004.29 ADV23906.1 - 0.071 13.5 0.0 0.65 10.4 0.0 2.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 ADV23906.1 - 0.08 12.7 0.0 0.2 11.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 ADV23906.1 - 0.085 12.9 0.4 0.49 10.4 0.0 2.5 2 1 0 2 2 1 0 AAA domain (dynein-related subfamily) ATP-synt_ab PF00006.25 ADV23906.1 - 0.092 12.4 0.0 0.16 11.6 0.0 1.5 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_25 PF13481.6 ADV23906.1 - 0.1 12.2 0.0 0.29 10.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain Cytidylate_kin PF02224.18 ADV23906.1 - 0.11 12.2 0.0 0.27 11.0 0.0 1.7 1 1 0 1 1 1 0 Cytidylate kinase AAA_23 PF13476.6 ADV23906.1 - 0.11 13.0 0.7 0.33 11.4 0.0 2.1 3 0 0 3 3 2 0 AAA domain AAA_18 PF13238.6 ADV23906.1 - 0.13 12.8 0.0 0.4 11.2 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 ADV23906.1 - 0.14 12.2 0.0 0.78 9.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain Acetyltransf_3 PF13302.7 ADV23907.1 - 7.6e-13 49.3 0.0 2.1e-12 47.9 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ADV23907.1 - 1.2e-05 25.5 0.0 2.2e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_8 PF13523.6 ADV23907.1 - 8.4e-05 22.3 0.0 0.00026 20.7 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain DUF4218 PF13960.6 ADV23909.1 - 0.00036 20.1 0.0 0.00057 19.5 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4218) MHB PF16525.5 ADV23909.1 - 0.082 13.2 0.1 0.42 10.9 0.0 2.0 2 0 0 2 2 2 0 Haemophore, haem-binding DHHA2 PF02833.14 ADV23910.1 - 1.5e-34 119.3 0.1 1.1e-33 116.4 0.1 2.0 2 0 0 2 2 2 1 DHHA2 domain DHH PF01368.20 ADV23910.1 - 1.9e-11 44.1 0.0 3.2e-11 43.4 0.0 1.4 1 0 0 1 1 1 1 DHH family TPR_1 PF00515.28 ADV23911.1 - 1.3e-14 53.3 3.7 5.3e-06 26.0 0.0 6.1 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_11 PF13414.6 ADV23911.1 - 5e-14 51.7 0.2 4.3e-06 26.3 0.0 5.2 5 1 1 6 6 6 2 TPR repeat TPR_2 PF07719.17 ADV23911.1 - 2.7e-13 48.9 8.7 0.0001 22.1 0.0 6.8 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_8 PF13181.6 ADV23911.1 - 5.5e-10 38.7 0.1 0.00056 19.9 0.0 4.9 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 ADV23911.1 - 2.4e-09 37.7 8.1 2.9e-08 34.2 0.0 5.0 4 1 2 6 6 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 ADV23911.1 - 9.3e-09 34.7 1.0 0.028 14.4 0.0 6.4 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_12 PF13424.6 ADV23911.1 - 1.9e-08 34.5 0.6 5.4e-06 26.6 0.0 4.8 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_17 PF13431.6 ADV23911.1 - 6.7e-08 32.4 0.0 0.00054 20.2 0.0 4.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 ADV23911.1 - 2.1e-07 31.4 0.1 0.00046 20.6 0.0 3.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 ADV23911.1 - 4.3e-07 30.2 14.2 0.0077 17.0 0.4 6.7 5 2 2 7 7 5 2 Tetratricopeptide repeat TPR_9 PF13371.6 ADV23911.1 - 7.4e-06 26.0 7.1 0.0004 20.5 0.0 4.6 5 0 0 5 5 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ADV23911.1 - 0.0012 19.0 0.1 0.0087 16.3 0.0 2.6 3 0 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 ADV23911.1 - 0.039 14.6 5.3 50 4.8 0.0 5.9 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_10 PF13374.6 ADV23911.1 - 0.12 12.3 2.4 22 5.1 0.0 4.8 5 0 0 5 5 5 0 Tetratricopeptide repeat MLTR_LBD PF17765.1 ADV23911.1 - 0.3 11.2 3.9 0.29 11.2 1.2 2.2 2 0 0 2 2 2 0 MmyB-like transcription regulator ligand binding domain GPI-anchored PF10342.9 ADV23912.1 - 5.1e-07 30.4 2.2 5.1e-07 30.4 2.2 2.0 2 0 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family SdrD_B PF17210.3 ADV23912.1 - 0.0081 16.4 2.5 0.86 9.8 0.2 2.3 1 1 1 2 2 2 2 SdrD B-like domain DUF515 PF04415.12 ADV23912.1 - 3.6 5.9 8.3 4.2 5.6 8.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF515) Fungal_trans PF04082.18 ADV23913.1 - 1.9e-17 63.2 3.0 3.9e-17 62.1 3.0 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ADV23913.1 - 0.00083 19.4 6.7 0.0015 18.6 6.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Astro_capsid_p PF12226.8 ADV23913.1 - 0.16 11.1 3.7 0.27 10.3 3.7 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Nop14 PF04147.12 ADV23913.1 - 0.31 9.2 6.7 0.47 8.6 6.7 1.1 1 0 0 1 1 1 0 Nop14-like family eIF-3c_N PF05470.12 ADV23913.1 - 0.58 8.4 2.0 0.78 8.0 2.0 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus SpoIIIAH PF12685.7 ADV23913.1 - 3.2 7.5 6.4 5.8 6.7 6.4 1.4 1 0 0 1 1 1 0 SpoIIIAH-like protein PBP1_TM PF14812.6 ADV23913.1 - 8.8 6.8 14.2 19 5.7 14.2 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DEAD PF00270.29 ADV23914.1 - 1.6e-29 102.9 0.0 2.6e-29 102.2 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ADV23914.1 - 2.1e-27 95.6 0.0 4.2e-27 94.7 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_30 PF13604.6 ADV23914.1 - 0.096 12.4 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 ADV23914.1 - 0.12 12.6 0.0 0.41 10.9 0.0 1.9 1 1 0 1 1 1 0 AAA domain LRR_8 PF13855.6 ADV23915.1 - 6.5e-07 29.0 7.9 2.5e-05 23.9 2.1 3.4 2 1 2 4 4 4 2 Leucine rich repeat LRR_4 PF12799.7 ADV23915.1 - 7.2e-07 29.4 10.0 6.7e-06 26.4 1.1 4.2 4 1 0 4 4 4 2 Leucine Rich repeats (2 copies) LRRNT_2 PF08263.12 ADV23915.1 - 0.00087 19.5 0.3 0.0028 17.9 0.3 1.9 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain LRR_6 PF13516.6 ADV23915.1 - 0.002 18.0 0.1 0.84 9.9 0.0 4.2 4 0 0 4 4 4 1 Leucine Rich repeat LRR_1 PF00560.33 ADV23915.1 - 0.002 18.4 3.8 1.4 9.8 0.2 4.4 4 1 0 4 4 4 2 Leucine Rich Repeat FNIP PF05725.12 ADV23915.1 - 0.43 10.8 13.7 0.75 10.0 2.2 3.5 3 1 0 4 4 4 0 FNIP Repeat STT3 PF02516.14 ADV23916.1 - 6.3e-123 411.3 39.9 1.2e-116 390.5 35.6 2.2 1 1 1 2 2 2 2 Oligosaccharyl transferase STT3 subunit GYF PF02213.16 ADV23917.1 - 0.0077 15.9 0.0 0.019 14.6 0.0 1.6 1 0 0 1 1 1 1 GYF domain T2SSF PF00482.23 ADV23917.1 - 0.66 9.9 2.9 1.1 9.2 2.9 1.3 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein F BP28CT PF08146.12 ADV23918.1 - 5e-34 117.4 0.3 7e-33 113.7 0.0 3.1 3 0 0 3 3 3 1 BP28CT (NUC211) domain U3snoRNP10 PF12397.8 ADV23918.1 - 5.2e-10 39.7 0.1 5.2e-10 39.7 0.1 6.2 7 1 1 8 8 8 2 U3 small nucleolar RNA-associated protein 10 HEAT PF02985.22 ADV23918.1 - 0.0075 16.4 10.5 0.29 11.5 0.2 5.4 5 0 0 5 5 5 2 HEAT repeat HEAT_2 PF13646.6 ADV23918.1 - 0.023 15.1 0.5 0.023 15.1 0.5 6.2 6 1 1 7 7 7 0 HEAT repeats RNA_pol_Rpb6 PF01192.22 ADV23919.1 - 3e-17 62.3 0.1 4.5e-17 61.7 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb6 Glyco_hydro_79C PF16862.5 ADV23920.1 - 1.1e-17 64.8 2.3 1.9e-17 64.0 0.6 2.3 3 0 0 3 3 3 1 Glycosyl hydrolase family 79 C-terminal beta domain Ndc80_HEC PF03801.13 ADV23920.1 - 0.1 12.2 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 HEC/Ndc80p family Kri1_C PF12936.7 ADV23921.1 - 7.7e-21 74.1 0.0 7.7e-21 74.1 0.0 6.1 6 1 2 8 8 8 1 KRI1-like family C-terminal Kri1 PF05178.12 ADV23921.1 - 2e-12 47.5 20.2 2e-12 47.5 20.2 6.9 5 3 0 5 5 5 1 KRI1-like family YL1 PF05764.13 ADV23921.1 - 0.0064 16.6 11.3 0.0064 16.6 11.3 4.9 4 1 0 4 4 4 1 YL1 nuclear protein GRIM-19 PF06212.12 ADV23922.1 - 5.3e-31 107.3 0.0 6.2e-31 107.1 0.0 1.0 1 0 0 1 1 1 1 GRIM-19 protein ABC_tran_Xtn PF12848.7 ADV23922.1 - 0.096 12.7 0.2 0.096 12.7 0.2 1.5 2 0 0 2 2 2 0 ABC transporter DUF865 PF05906.11 ADV23922.1 - 0.11 12.3 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 Herpesvirus-7 repeat of unknown function (DUF865) Vps55 PF04133.14 ADV23923.1 - 1e-41 141.6 7.9 1.1e-41 141.4 7.9 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting 55 Asp PF00026.23 ADV23924.1 - 5.4e-31 108.2 0.1 2.2e-15 56.9 0.1 2.5 2 0 0 2 2 2 2 Eukaryotic aspartyl protease TAXi_N PF14543.6 ADV23924.1 - 2.7e-09 37.5 2.1 4.3e-09 36.8 0.3 2.3 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal Myb_DNA-bind_3 PF12776.7 ADV23925.1 - 4.6e-22 78.8 0.4 9.6e-22 77.8 0.1 1.7 2 0 0 2 2 2 1 Myb/SANT-like DNA-binding domain Myb_DNA-bind_4 PF13837.6 ADV23925.1 - 7.5e-09 35.9 0.0 1.7e-08 34.7 0.0 1.6 1 1 0 1 1 1 1 Myb/SANT-like DNA-binding domain Myb_DNA-bind_5 PF13873.6 ADV23925.1 - 0.0025 17.9 0.1 0.0065 16.5 0.1 1.7 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain Myb_DNA-binding PF00249.31 ADV23925.1 - 0.0048 17.1 0.1 0.0089 16.2 0.1 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ADV23925.1 - 0.011 16.0 0.2 0.021 15.1 0.2 1.6 1 0 0 1 1 1 0 Myb-like DNA-binding domain PTH2 PF01981.16 ADV23926.1 - 4.5e-40 136.6 0.3 5.8e-40 136.2 0.3 1.1 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 DUF4112 PF13430.6 ADV23927.1 - 1.7e-30 105.4 1.0 2.3e-30 105.0 1.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4112) Sod_Fe_N PF00081.22 ADV23928.1 - 5.9e-34 116.4 1.8 8e-34 116.0 1.0 1.7 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Sod_Fe_C PF02777.18 ADV23928.1 - 1.3e-33 115.2 0.1 2.2e-33 114.5 0.1 1.3 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Pyrid_ox_like PF16242.5 ADV23929.1 - 9.2e-18 64.3 0.0 1.4e-17 63.7 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase like Putative_PNPOx PF01243.20 ADV23929.1 - 1.2e-08 35.0 0.0 2e-08 34.3 0.0 1.3 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Glyco_hydro_79C PF16862.5 ADV23930.1 - 1.3e-17 64.6 1.5 1.3e-17 64.6 1.5 2.4 3 0 0 3 3 3 1 Glycosyl hydrolase family 79 C-terminal beta domain SCP2 PF02036.17 ADV23931.1 - 1e-23 83.7 0.3 1.3e-23 83.4 0.3 1.1 1 0 0 1 1 1 1 SCP-2 sterol transfer family Alkyl_sulf_C PF14864.6 ADV23931.1 - 0.0031 17.8 0.0 0.0039 17.4 0.0 1.2 1 0 0 1 1 1 1 Alkyl sulfatase C-terminal Frataxin_Cyay PF01491.16 ADV23931.1 - 0.15 12.1 0.0 0.2 11.7 0.0 1.2 1 0 0 1 1 1 0 Frataxin-like domain Glyco_hydro_79C PF16862.5 ADV23932.1 - 1.9e-18 67.2 2.8 1.9e-18 67.2 0.9 2.1 2 0 0 2 2 2 1 Glycosyl hydrolase family 79 C-terminal beta domain DUF2015 PF09435.10 ADV23933.1 - 5.2e-32 110.0 0.0 6.1e-32 109.8 0.0 1.0 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF2015) Fungal_trans PF04082.18 ADV23934.1 - 8.1e-09 34.9 0.1 1.7e-08 33.8 0.1 1.5 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ADV23934.1 - 4.7e-07 29.8 8.9 8.9e-07 28.9 8.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ribosomal_S10 PF00338.22 ADV23935.1 - 4.8e-26 90.9 0.0 7.7e-26 90.2 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e zf-CCCH PF00642.24 ADV23936.1 - 1.2e-12 47.4 12.5 1.3e-07 31.3 1.3 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 ADV23936.1 - 0.00033 20.6 1.4 0.00033 20.6 1.4 2.5 2 0 0 2 2 2 1 Zinc finger domain RRM_1 PF00076.22 ADV23936.1 - 0.18 11.7 0.0 0.42 10.5 0.0 1.6 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Rad21_Rec8_N PF04825.13 ADV23937.1 - 7.1e-26 90.5 0.0 1.6e-25 89.4 0.0 1.5 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.16 ADV23937.1 - 3.7e-11 42.1 0.0 8e-11 41.1 0.0 1.6 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein SMC_ScpA PF02616.14 ADV23937.1 - 0.0033 17.4 0.1 0.0033 17.4 0.1 2.0 2 0 0 2 2 2 1 Segregation and condensation protein ScpA YL1 PF05764.13 ADV23937.1 - 0.13 12.4 12.3 0.37 10.9 12.3 1.6 1 1 0 1 1 1 0 YL1 nuclear protein Spore_III_AB PF09548.10 ADV23937.1 - 0.66 10.1 5.1 9.3 6.3 1.9 2.2 2 0 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) DUF4337 PF14235.6 ADV23937.1 - 7.1 6.7 5.9 14 5.7 5.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) ATG27 PF09451.10 ADV23938.1 - 5.4e-60 203.5 0.0 6.5e-60 203.2 0.0 1.0 1 0 0 1 1 1 1 Autophagy-related protein 27 CIMR PF00878.18 ADV23938.1 - 0.0032 17.5 0.0 0.57 10.2 0.0 2.1 2 0 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat Man-6-P_recep PF02157.15 ADV23938.1 - 0.0088 15.2 0.2 0.014 14.5 0.2 1.2 1 0 0 1 1 1 1 Mannose-6-phosphate receptor Abhydrolase_3 PF07859.13 ADV23940.1 - 8e-32 110.8 0.0 1.2e-31 110.3 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 ADV23940.1 - 9e-14 51.1 0.0 1.3e-13 50.6 0.0 1.1 1 0 0 1 1 1 1 Steryl acetyl hydrolase COesterase PF00135.28 ADV23940.1 - 0.031 13.1 0.1 0.068 12.0 0.0 1.5 2 0 0 2 2 2 0 Carboxylesterase family DUF2974 PF11187.8 ADV23940.1 - 0.22 11.1 0.0 0.34 10.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) RseC_MucC PF04246.12 ADV23941.1 - 0.29 11.1 1.0 4.2 7.3 0.1 2.4 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC MFS_1 PF07690.16 ADV23942.1 - 4e-40 137.8 57.7 1.4e-39 136.0 54.1 2.6 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 ADV23942.1 - 4.1e-11 42.0 17.2 1.2e-10 40.5 17.3 1.6 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) B12D PF06522.11 ADV23942.1 - 0.28 11.0 0.1 0.28 11.0 0.1 3.2 4 0 0 4 4 4 0 NADH-ubiquinone reductase complex 1 MLRQ subunit TauD PF02668.16 ADV23943.1 - 5.5e-62 210.0 0.2 6.3e-62 209.8 0.2 1.0 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family SRP40_C PF05022.12 ADV23946.1 - 5.8e-27 94.3 1.9 1.3e-26 93.2 1.9 1.7 1 0 0 1 1 1 1 SRP40, C-terminal domain LisH PF08513.11 ADV23946.1 - 1.5e-06 27.9 0.0 2.5e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 LisH Spt5_N PF11942.8 ADV23946.1 - 0.00076 20.4 4.7 0.00076 20.4 4.7 2.9 3 0 0 3 3 3 1 Spt5 transcription elongation factor, acidic N-terminal Zn_clus PF00172.18 ADV23947.1 - 4.6e-07 29.8 11.7 8.3e-07 29.0 11.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 ADV23947.1 - 0.00018 20.6 0.3 0.054 12.5 0.1 2.3 2 0 0 2 2 2 2 Fungal specific transcription factor domain MFS_1 PF07690.16 ADV23948.1 - 4.6e-38 131.0 19.9 4.6e-38 131.0 19.9 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily Glyco_hydro_88 PF07470.13 ADV23949.1 - 1.5e-09 37.4 0.5 2.4e-09 36.7 0.5 1.3 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 FAM199X PF15814.5 ADV23949.1 - 2.2 7.3 6.5 3.8 6.5 6.5 1.3 1 0 0 1 1 1 0 Protein family FAM199X ZT_dimer PF16916.5 ADV23950.1 - 1.9e-14 53.5 0.0 8.3e-14 51.5 0.0 2.1 2 0 0 2 2 2 1 Dimerisation domain of Zinc Transporter Cation_efflux PF01545.21 ADV23950.1 - 2.9e-14 53.3 5.4 3.6e-14 53.0 5.4 1.1 1 0 0 1 1 1 1 Cation efflux family DUF1201 PF06716.11 ADV23950.1 - 0.13 12.2 0.5 0.13 12.2 0.5 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1201) TrkA_TMD PF18613.1 ADV23950.1 - 2.7 7.5 6.4 6.5 6.3 6.4 1.7 1 0 0 1 1 1 0 Tyrosine kinase receptor A trans-membrane domain Cation_efflux PF01545.21 ADV23951.1 - 5e-16 59.0 1.9 6.2e-16 58.7 1.9 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 ADV23951.1 - 1.3e-09 38.0 0.0 3.3e-09 36.7 0.0 1.6 2 0 0 2 2 2 1 Dimerisation domain of Zinc Transporter PI3_PI4_kinase PF00454.27 ADV23952.1 - 9.4e-35 120.6 0.0 1.7e-32 113.2 0.0 2.5 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 ADV23952.1 - 2.2e-22 79.4 0.0 5.5e-22 78.1 0.0 1.7 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF4135 PF13575.6 ADV23952.1 - 0.087 12.1 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) Ribosomal_S11 PF00411.19 ADV23953.1 - 0.00031 21.1 0.4 0.00088 19.7 0.4 1.8 1 1 0 1 1 1 1 Ribosomal protein S11 Zn_clus PF00172.18 ADV23954.1 - 5.2e-10 39.3 10.9 1.4e-09 37.9 10.9 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain UQ_con PF00179.26 ADV23955.1 - 1.7e-44 150.8 0.0 2e-44 150.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 ADV23955.1 - 1.1e-05 25.2 0.0 1.4e-05 24.8 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B KH_1 PF00013.29 ADV23956.1 - 1.4e-92 303.5 38.1 2.7e-14 52.7 1.1 14.3 14 0 0 14 14 14 11 KH domain SLS PF14611.6 ADV23956.1 - 1.3e-05 25.2 13.3 0.12 12.2 0.1 6.9 8 1 1 9 9 9 3 Mitochondrial inner-membrane-bound regulator KH_4 PF13083.6 ADV23956.1 - 0.00035 20.4 13.4 0.25 11.2 0.0 6.6 6 1 0 6 6 6 2 KH domain KH_5 PF13184.6 ADV23956.1 - 0.14 12.2 18.3 3 8.0 0.1 6.8 7 1 1 8 8 8 0 NusA-like KH domain KH_2 PF07650.17 ADV23956.1 - 1.1 9.2 42.6 1 9.3 1.2 9.6 7 5 2 9 9 9 0 KH domain SPOB_a PF14689.6 ADV23956.1 - 1.1 9.0 2.4 6.2 6.6 0.3 2.8 3 0 0 3 3 3 0 Sensor_kinase_SpoOB-type, alpha-helical domain Malic_M PF03949.15 ADV23957.1 - 2.6e-84 282.5 0.0 3.9e-84 282.0 0.0 1.3 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 ADV23957.1 - 4.6e-59 199.3 0.0 6.9e-59 198.7 0.0 1.3 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain ThrE PF06738.12 ADV23958.1 - 1.6e-37 129.1 24.1 4.7e-32 111.3 8.5 3.1 2 1 0 2 2 2 2 Putative threonine/serine exporter ThrE_2 PF12821.7 ADV23958.1 - 1.9e-17 63.6 4.8 1.9e-17 63.6 4.8 2.9 2 2 0 2 2 2 1 Threonine/Serine exporter, ThrE Glyco_tranf_2_3 PF13641.6 ADV23959.1 - 3.6e-28 99.0 0.0 5.1e-28 98.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 ADV23959.1 - 4.1e-10 39.7 0.0 6.2e-10 39.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 ADV23959.1 - 1.7e-06 27.6 0.1 8.4e-06 25.4 0.1 1.9 1 1 0 1 1 1 1 Glycosyl transferase family 21 Telomere_reg-2 PF10193.9 ADV23960.1 - 1.6e-28 99.3 0.0 6.4e-28 97.4 0.0 2.1 2 0 0 2 2 2 1 Telomere length regulation protein RTP1_C1 PF10363.9 ADV23960.1 - 0.04 14.1 0.0 21 5.3 0.0 3.3 3 0 0 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_EZ PF13513.6 ADV23960.1 - 0.089 13.3 0.4 1 9.9 0.2 2.9 2 0 0 2 2 2 0 HEAT-like repeat NAD_kinase PF01513.21 ADV23961.1 - 1.3e-68 231.4 0.0 4e-68 229.7 0.0 1.8 1 1 0 1 1 1 1 ATP-NAD kinase DUF1677 PF07911.13 ADV23961.1 - 0.05 14.0 0.8 0.11 12.9 0.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1677) ABC_tran PF00005.27 ADV23962.1 - 8.3e-21 74.9 0.0 6.6e-13 49.4 0.0 3.2 3 1 0 3 3 3 2 ABC transporter AAA_21 PF13304.6 ADV23962.1 - 1.3e-08 35.0 2.9 0.0028 17.5 0.4 3.2 2 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ADV23962.1 - 0.0076 16.0 0.0 0.015 15.0 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF3584 PF12128.8 ADV23962.1 - 0.033 11.7 0.0 0.05 11.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) SMC_N PF02463.19 ADV23962.1 - 0.099 12.1 0.0 2.2 7.7 0.0 2.6 3 0 0 3 3 3 0 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 ADV23962.1 - 0.12 12.7 0.0 2.9 8.2 0.0 2.6 1 1 0 1 1 1 0 AAA domain AAA_15 PF13175.6 ADV23962.1 - 0.14 11.8 0.1 0.23 11.1 0.1 1.2 1 0 0 1 1 1 0 AAA ATPase domain AAA_19 PF13245.6 ADV23962.1 - 0.17 12.2 0.0 0.36 11.1 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_23 PF13476.6 ADV23962.1 - 0.69 10.4 1.8 0.54 10.7 0.3 1.6 2 0 0 2 2 2 0 AAA domain ORC6 PF05460.13 ADV23962.1 - 2.5 7.3 3.8 12 5.1 0.3 2.5 3 0 0 3 3 3 0 Origin recognition complex subunit 6 (ORC6) zf-C2H2_3 PF13878.6 ADV23963.1 - 0.14 12.0 0.1 0.38 10.6 0.1 1.7 1 0 0 1 1 1 0 zinc-finger of acetyl-transferase ESCO Uricase PF01014.18 ADV23964.1 - 7.3e-61 204.2 0.0 5.9e-33 113.9 0.1 2.0 2 0 0 2 2 2 2 Uricase Got1 PF04178.12 ADV23965.1 - 1.6e-27 96.2 11.5 1.9e-27 95.9 11.5 1.2 1 0 0 1 1 1 1 Got1/Sft2-like family HlyIII PF03006.20 ADV23965.1 - 0.025 14.3 7.1 0.036 13.8 7.1 1.2 1 0 0 1 1 1 0 Haemolysin-III related DUF5090 PF17009.5 ADV23965.1 - 0.097 12.6 9.8 0.11 12.4 9.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF5090) Cpn60_TCP1 PF00118.24 ADV23966.1 - 7.5e-161 536.1 1.8 8.6e-161 535.9 1.8 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family NUDE_C PF04880.13 ADV23967.1 - 1.2e-10 42.2 10.8 1.2e-10 42.2 10.8 6.9 3 2 3 7 7 4 1 NUDE protein, C-terminal conserved region DUF2353 PF09789.9 ADV23967.1 - 0.00012 21.5 10.6 0.00012 21.5 10.6 2.2 1 1 1 2 2 2 1 Uncharacterized coiled-coil protein (DUF2353) Rab5-bind PF09311.11 ADV23967.1 - 0.063 12.7 22.7 0.11 11.9 22.7 1.3 1 0 0 1 1 1 0 Rabaptin-like protein DUF3584 PF12128.8 ADV23967.1 - 0.068 10.7 23.1 0.098 10.2 23.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) PRKG1_interact PF15898.5 ADV23967.1 - 0.09 13.7 0.5 0.09 13.7 0.5 3.6 1 1 3 4 4 4 0 cGMP-dependent protein kinase interacting domain ZapB PF06005.12 ADV23967.1 - 0.098 13.1 36.5 0.69 10.4 12.0 3.4 1 1 2 3 3 3 0 Cell division protein ZapB HIP1_clath_bdg PF16515.5 ADV23967.1 - 1.1 10.0 24.4 4.5 8.0 2.0 2.5 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 PSII_Pbs27 PF13326.6 ADV23967.1 - 1.4 9.3 5.9 0.2 12.0 1.3 1.9 2 0 0 2 2 2 0 Photosystem II Pbs27 DUF3037 PF11236.8 ADV23967.1 - 2.2 8.7 8.1 0.9 10.0 2.7 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3037) DUF1664 PF07889.12 ADV23967.1 - 3.3 7.8 9.5 6.3 6.9 4.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) FapA PF03961.13 ADV23967.1 - 4.4 5.8 19.1 4.9 5.6 8.6 2.1 1 1 1 2 2 2 0 Flagellar Assembly Protein A Mis14 PF08641.12 ADV23968.1 - 0.0017 18.6 2.1 0.003 17.9 2.1 1.4 1 1 0 1 1 1 1 Kinetochore protein Mis14 like DUF3336 PF11815.8 ADV23968.1 - 0.054 13.2 0.6 0.2 11.3 0.6 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF3336) CBF PF03914.17 ADV23969.1 - 4.7e-18 65.8 0.0 4.7e-18 65.8 0.0 3.5 4 1 0 4 4 4 1 CBF/Mak21 family NOC3p PF07540.11 ADV23969.1 - 2.6e-17 63.0 0.4 1.1e-16 61.0 0.0 2.4 2 0 0 2 2 2 1 Nucleolar complex-associated protein HisKA_2 PF07568.12 ADV23969.1 - 0.046 13.8 0.8 0.09 12.9 0.0 1.8 2 0 0 2 2 2 0 Histidine kinase DBD_Tnp_Mut PF03108.15 ADV23970.1 - 0.13 12.3 1.3 1.6 8.8 0.1 2.3 1 1 1 2 2 2 0 MuDR family transposase Methyltransf_23 PF13489.6 ADV23971.1 - 0.0033 17.3 0.0 0.012 15.4 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Competence PF03772.16 ADV23971.1 - 0.083 12.2 0.1 0.12 11.6 0.1 1.1 1 0 0 1 1 1 0 Competence protein Tropomyosin_1 PF12718.7 ADV23972.1 - 0.00011 22.3 33.8 0.018 15.2 7.8 2.3 1 1 1 2 2 2 2 Tropomyosin like DUF812 PF05667.11 ADV23972.1 - 0.001 18.1 11.8 0.0017 17.4 11.8 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF812) RasGAP_C PF03836.15 ADV23972.1 - 0.004 17.3 7.1 0.2 11.8 2.9 2.4 2 0 0 2 2 2 2 RasGAP C-terminus FlaC_arch PF05377.11 ADV23972.1 - 0.0047 17.3 11.3 0.083 13.3 3.3 3.8 3 0 0 3 3 3 1 Flagella accessory protein C (FlaC) Exonuc_V_gamma PF04257.14 ADV23972.1 - 0.054 11.7 2.5 0.081 11.1 2.5 1.1 1 0 0 1 1 1 0 Exodeoxyribonuclease V, gamma subunit Macoilin PF09726.9 ADV23972.1 - 0.059 11.9 21.6 0.13 10.8 21.6 1.5 1 0 0 1 1 1 0 Macoilin family AAA_13 PF13166.6 ADV23972.1 - 0.095 11.3 16.1 0.15 10.7 16.1 1.2 1 0 0 1 1 1 0 AAA domain Tropomyosin PF00261.20 ADV23972.1 - 0.13 11.6 30.2 0.21 10.9 30.2 1.3 1 0 0 1 1 1 0 Tropomyosin TPR_MLP1_2 PF07926.12 ADV23972.1 - 0.15 12.1 33.5 1.8 8.7 5.2 2.7 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein GAS PF13851.6 ADV23972.1 - 0.16 11.3 29.3 0.04 13.3 15.6 2.2 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding ATG16 PF08614.11 ADV23972.1 - 0.22 11.7 30.7 0.59 10.3 14.3 3.0 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) Spc7 PF08317.11 ADV23972.1 - 0.24 10.2 31.0 0.95 8.3 17.1 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein BRE1 PF08647.11 ADV23972.1 - 0.25 11.4 25.0 0.071 13.2 9.1 3.4 2 1 1 3 3 3 0 BRE1 E3 ubiquitin ligase DHR10 PF18595.1 ADV23972.1 - 0.27 11.3 30.0 0.91 9.6 4.8 2.4 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain Striatin PF08232.12 ADV23972.1 - 0.39 11.3 17.8 1.3 9.6 17.8 2.0 1 0 0 1 1 1 0 Striatin family MAD PF05557.13 ADV23972.1 - 0.72 8.1 26.9 0.98 7.7 26.9 1.1 1 0 0 1 1 1 0 Mitotic checkpoint protein DUF3584 PF12128.8 ADV23972.1 - 1.3 6.5 25.3 1.8 6.0 25.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF3450 PF11932.8 ADV23972.1 - 1.8 7.8 26.1 7.5 5.8 5.0 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Fib_alpha PF08702.10 ADV23972.1 - 1.8 8.7 15.4 0.53 10.5 7.9 2.2 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF4200 PF13863.6 ADV23972.1 - 2.7 8.4 31.3 1.8 9.0 9.4 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) Occludin_ELL PF07303.13 ADV23972.1 - 3.4 8.4 10.0 4.3 8.1 4.3 2.4 2 0 0 2 2 2 0 Occludin homology domain Prefoldin_2 PF01920.20 ADV23972.1 - 3.7 7.6 21.2 7.1 6.6 0.1 3.7 2 1 0 2 2 1 0 Prefoldin subunit DUF1664 PF07889.12 ADV23972.1 - 6.7 6.8 17.7 5 7.2 6.8 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) RNA_pol_Rpb8 PF03870.15 ADV23973.1 - 8.2e-41 139.5 1.5 5.3e-40 136.8 1.5 1.9 1 1 0 1 1 1 1 RNA polymerase Rpb8 Ribonuclease_P PF00825.18 ADV23973.1 - 0.043 13.9 0.0 0.071 13.2 0.0 1.4 1 0 0 1 1 1 0 Ribonuclease P PWWP PF00855.17 ADV23974.1 - 6.6e-20 71.3 0.0 6.6e-20 71.3 0.0 2.9 3 0 0 3 3 3 1 PWWP domain Med26 PF08711.11 ADV23974.1 - 0.00084 19.3 0.0 0.0028 17.7 0.0 1.9 1 0 0 1 1 1 1 TFIIS helical bundle-like domain DivIC PF04977.15 ADV23974.1 - 0.18 11.6 1.4 0.67 9.8 1.4 1.9 1 0 0 1 1 1 0 Septum formation initiator BNIP2 PF12496.8 ADV23974.1 - 2 8.9 9.9 0.27 11.7 1.2 2.5 2 0 0 2 2 2 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 TRP PF06011.12 ADV23975.1 - 2.4e-77 260.5 24.3 3.2e-77 260.1 24.3 1.1 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 ADV23975.1 - 3.6e-30 105.1 2.1 5.6e-30 104.5 2.1 1.3 1 0 0 1 1 1 1 ML-like domain DNA_ligase_A_M PF01068.21 ADV23976.1 - 7.6e-66 221.6 0.2 1.6e-65 220.6 0.2 1.6 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 ADV23976.1 - 7e-48 163.2 0.4 1.6e-47 162.1 0.4 1.6 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 ADV23976.1 - 1.9e-23 82.9 0.0 6e-23 81.3 0.0 1.9 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region RNA_ligase PF09414.10 ADV23976.1 - 2.2e-06 28.1 0.0 4.1e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 RNA ligase FAS_N PF17828.1 ADV23976.1 - 0.021 14.9 0.0 0.065 13.2 0.0 1.8 1 0 0 1 1 1 0 N-terminal domain in fatty acid synthase subunit beta DDRGK PF09756.9 ADV23976.1 - 5.1 6.7 10.8 0.73 9.4 5.1 2.3 2 0 0 2 2 2 0 DDRGK domain Transp_cyt_pur PF02133.15 ADV23977.1 - 7.7e-20 71.1 41.9 1.7e-19 69.9 41.9 1.6 1 1 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin 4HBT_3 PF13622.6 ADV23978.1 - 8.4e-36 124.5 0.0 5.7e-35 121.8 0.0 1.8 1 1 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.15 ADV23978.1 - 7.4e-13 48.5 0.0 6.2e-09 35.8 0.0 2.3 2 0 0 2 2 2 2 Acyl-CoA thioesterase Tho1_MOS11_C PF18592.1 ADV23979.1 - 6.3e-05 22.7 1.7 0.36 10.7 0.1 3.4 3 0 0 3 3 3 3 Tho1/MOS11 C-terminal domain DltD PF04914.12 ADV23979.1 - 0.035 13.5 2.0 0.042 13.2 2.0 1.2 1 0 0 1 1 1 0 DltD protein Pkinase PF00069.25 ADV23980.1 - 5.5e-75 252.1 0.0 7.7e-75 251.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV23980.1 - 4.7e-35 121.1 0.0 7.5e-35 120.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ADV23980.1 - 1.5e-08 34.3 0.1 2.5e-08 33.6 0.0 1.6 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 ADV23980.1 - 8.1e-07 28.2 0.0 1.5e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 ADV23980.1 - 5.3e-06 25.9 0.4 1.1e-05 24.9 0.1 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 ADV23980.1 - 0.0025 17.4 0.6 0.0047 16.5 0.0 1.7 2 0 0 2 2 2 1 PhoP regulatory network protein YrbL APH PF01636.23 ADV23980.1 - 0.004 17.1 0.0 0.05 13.5 0.0 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family PrkA PF06798.12 ADV23980.1 - 0.041 13.5 0.1 0.07 12.7 0.1 1.3 1 0 0 1 1 1 0 PrkA serine protein kinase C-terminal domain DUF2203 PF09969.9 ADV23980.1 - 0.061 14.1 0.8 8.1 7.2 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) SNARE PF05739.19 ADV23981.1 - 0.081 12.9 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 SNARE domain Exo_endo_phos PF03372.23 ADV23982.1 - 1.9e-06 27.6 0.2 5.4e-06 26.1 0.2 1.8 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 ADV23982.1 - 0.0015 18.3 0.0 0.049 13.5 0.0 2.7 2 1 0 2 2 2 1 Endonuclease-reverse transcriptase Peptidase_M28 PF04389.17 ADV23983.1 - 1.2e-26 93.7 0.0 1.6e-26 93.3 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 ADV23983.1 - 5.2e-08 32.8 0.0 1.1e-07 31.7 0.0 1.5 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 PAS_3 PF08447.12 ADV23984.1 - 0.00014 22.1 0.0 0.00024 21.3 0.0 1.3 1 0 0 1 1 1 1 PAS fold Zn_clus PF00172.18 ADV23984.1 - 0.0085 16.2 9.8 0.012 15.7 9.8 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS_9 PF13426.7 ADV23984.1 - 0.049 13.9 0.0 0.1 12.9 0.0 1.5 1 0 0 1 1 1 0 PAS domain PAS PF00989.25 ADV23984.1 - 0.058 13.4 0.0 0.1 12.6 0.0 1.3 1 0 0 1 1 1 0 PAS fold Peptidase_M48 PF01435.18 ADV23985.1 - 1.4e-30 106.5 0.0 3.1e-30 105.4 0.0 1.5 2 0 0 2 2 2 1 Peptidase family M48 Peptidase_U49 PF10463.9 ADV23985.1 - 0.018 14.8 0.3 0.66 9.7 0.0 2.2 2 0 0 2 2 2 0 Peptidase U49 EXS PF03124.14 ADV23986.1 - 1e-78 265.0 32.1 1.3e-78 264.6 32.1 1.1 1 0 0 1 1 1 1 EXS family SPX PF03105.19 ADV23986.1 - 5.6e-50 171.4 19.6 1.5e-48 166.6 19.6 2.2 1 1 0 1 1 1 1 SPX domain CHAD PF05235.14 ADV23986.1 - 0.0025 17.8 3.0 0.0061 16.6 3.0 1.7 1 0 0 1 1 1 1 CHAD domain zf-RanBP PF00641.18 ADV23987.1 - 9e-09 34.5 24.3 1.4e-05 24.3 3.1 3.5 3 0 0 3 3 3 3 Zn-finger in Ran binding protein and others zf-Sec23_Sec24 PF04810.15 ADV23987.1 - 0.0089 16.1 9.7 3 8.0 0.1 4.1 3 1 1 4 4 4 2 Sec23/Sec24 zinc finger DUF1579 PF07617.11 ADV23987.1 - 1.6 8.6 3.2 92 2.9 0.6 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF1579) Prim_Zn_Ribbon PF08273.12 ADV23987.1 - 2.1 8.7 6.7 37 4.7 0.2 3.3 3 0 0 3 3 3 0 Zinc-binding domain of primase-helicase PHD_2 PF13831.6 ADV23987.1 - 7 6.3 6.0 59 3.3 0.2 3.5 3 0 0 3 3 3 0 PHD-finger Pmp3 PF01679.17 ADV23988.1 - 9.1e-14 51.4 8.0 1.4e-13 50.8 8.0 1.3 1 0 0 1 1 1 1 Proteolipid membrane potential modulator Pkinase PF00069.25 ADV23989.1 - 1.3e-59 201.7 0.0 1.7e-59 201.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV23989.1 - 3.4e-29 101.9 0.0 4.7e-29 101.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 ADV23989.1 - 0.049 12.6 0.1 0.082 11.8 0.1 1.3 1 0 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 ADV23989.1 - 0.058 13.3 0.0 0.23 11.3 0.0 1.9 2 0 0 2 2 2 0 Phosphotransferase enzyme family Kinase-like PF14531.6 ADV23989.1 - 0.093 12.0 0.0 2.6 7.3 0.0 2.3 2 0 0 2 2 2 0 Kinase-like DUF4530 PF15039.6 ADV23989.1 - 0.41 10.8 3.7 1 9.5 3.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4530) Tim17 PF02466.19 ADV23991.1 - 1.1e-32 112.7 4.1 1.3e-32 112.4 4.1 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family HSCB_C PF07743.13 ADV23992.1 - 1.7e-17 63.6 0.4 1e-16 61.2 0.4 1.9 2 0 0 2 2 2 1 HSCB C-terminal oligomerisation domain DnaJ PF00226.31 ADV23992.1 - 0.00031 20.8 0.0 0.00081 19.5 0.0 1.7 1 0 0 1 1 1 1 DnaJ domain DZR PF12773.7 ADV23992.1 - 0.066 13.3 0.4 0.11 12.5 0.4 1.3 1 0 0 1 1 1 0 Double zinc ribbon UPF0547 PF10571.9 ADV23992.1 - 1.1 9.5 8.3 10 6.3 8.7 2.1 1 1 1 2 2 2 0 Uncharacterised protein family UPF0547 NDUF_B12 PF08122.12 ADV23993.1 - 1.9e-20 72.7 0.5 2.4e-20 72.3 0.5 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B12 subunit family ThuA PF06283.11 ADV23994.1 - 2.4e-52 178.2 0.0 3e-52 177.9 0.0 1.1 1 0 0 1 1 1 1 Trehalose utilisation MRP-L47 PF06984.13 ADV23995.1 - 3.3e-20 72.0 0.0 5.2e-20 71.4 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) Ribosomal_L29 PF00831.23 ADV23995.1 - 0.00059 19.8 1.4 0.002 18.0 1.4 1.9 1 1 0 1 1 1 1 Ribosomal L29 protein GlgS PF08971.11 ADV23995.1 - 0.048 13.7 0.0 0.1 12.6 0.0 1.5 1 0 0 1 1 1 0 Glycogen synthesis protein Clathrin PF00637.20 ADV23996.1 - 5.4e-28 97.7 0.5 1.5e-27 96.2 0.1 2.0 2 0 0 2 2 2 1 Region in Clathrin and VPS Vps39_1 PF10366.9 ADV23996.1 - 1.1e-05 25.6 0.2 0.0011 19.2 0.0 2.9 1 1 1 2 2 2 1 Vacuolar sorting protein 39 domain 1 Vps39_2 PF10367.9 ADV23996.1 - 0.00032 21.1 1.5 0.00038 20.9 0.0 1.9 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 2 zf-C3H2C3 PF17122.5 ADV23996.1 - 0.05 13.6 4.5 0.055 13.5 0.1 2.9 3 0 0 3 3 3 0 Zinc-finger zf-RING_5 PF14634.6 ADV23996.1 - 0.085 12.8 0.9 2.3 8.3 0.0 2.8 3 0 0 3 3 3 0 zinc-RING finger domain zf-RING_2 PF13639.6 ADV23996.1 - 0.11 12.9 4.0 0.42 11.0 0.5 3.0 3 0 0 3 3 3 0 Ring finger domain Mcl1_mid PF12341.8 ADV23996.1 - 0.15 11.4 0.0 0.25 10.6 0.0 1.2 1 0 0 1 1 1 0 Minichromosome loss protein, Mcl1, middle region Zn_ribbon_17 PF17120.5 ADV23996.1 - 1.3 8.7 6.7 1.4 8.6 1.1 2.7 3 0 0 3 3 3 0 Zinc-ribbon, C4HC2 type CDC45 PF02724.14 ADV23996.1 - 2 6.6 23.4 3.9 5.6 23.4 1.4 1 0 0 1 1 1 0 CDC45-like protein ORC6 PF05460.13 ADV23996.1 - 4.3 6.5 15.2 8.3 5.6 15.2 1.4 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Presenilin PF01080.17 ADV23996.1 - 5.4 5.7 11.4 10 4.8 11.4 1.4 1 0 0 1 1 1 0 Presenilin RNase_HII PF01351.18 ADV23997.1 - 6e-50 169.9 0.0 7e-50 169.6 0.0 1.0 1 0 0 1 1 1 1 Ribonuclease HII GSH-S_N PF02951.14 ADV23997.1 - 0.18 11.9 0.0 0.31 11.2 0.0 1.4 1 0 0 1 1 1 0 Prokaryotic glutathione synthetase, N-terminal domain SAE2 PF08573.10 ADV23998.1 - 1.3e-14 55.3 6.4 1.3e-14 55.3 6.4 4.1 3 1 0 3 3 3 1 DNA repair protein endonuclease SAE2/CtIP C-terminus Med30 PF11315.8 ADV23998.1 - 0.037 14.2 0.9 0.17 12.1 0.1 2.2 2 0 0 2 2 2 0 Mediator complex subunit 30 BRE1 PF08647.11 ADV23999.1 - 4e-23 81.3 8.6 4e-23 81.3 8.6 7.3 7 0 0 7 7 7 1 BRE1 E3 ubiquitin ligase zf-C3HC4_3 PF13920.6 ADV23999.1 - 1.9e-06 27.6 12.8 3.1e-06 26.9 12.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ADV23999.1 - 4.6e-06 26.4 16.7 8.5e-06 25.5 16.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ADV23999.1 - 3.1e-05 24.2 13.2 5.5e-05 23.4 13.2 1.4 1 0 0 1 1 1 1 Ring finger domain Spc7 PF08317.11 ADV23999.1 - 6.3e-05 22.0 6.2 6.3e-05 22.0 6.2 6.6 4 2 2 6 6 6 2 Spc7 kinetochore protein zf-RING_UBOX PF13445.6 ADV23999.1 - 0.00016 21.6 10.7 0.0003 20.7 10.7 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 ADV23999.1 - 0.00022 21.0 15.7 0.00042 20.1 15.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ADV23999.1 - 0.0018 18.1 11.2 0.0033 17.3 11.2 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 ADV23999.1 - 0.0021 18.0 16.2 0.0043 17.0 16.2 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_6 PF14835.6 ADV23999.1 - 0.0085 15.9 3.7 0.016 15.1 3.7 1.4 1 0 0 1 1 1 1 zf-RING of BARD1-type protein DUF1272 PF06906.11 ADV23999.1 - 0.017 15.2 7.6 0.04 14.0 7.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) zf-rbx1 PF12678.7 ADV23999.1 - 0.069 13.4 10.3 0.17 12.2 10.3 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 ADV23999.1 - 0.43 10.8 12.9 0.8 9.9 12.9 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-Nse PF11789.8 ADV23999.1 - 0.85 9.5 4.9 1.8 8.5 4.9 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Trm112p PF03966.16 ADV23999.1 - 1.1 9.9 4.2 8.2 7.1 4.2 2.6 1 0 0 1 1 1 0 Trm112p-like protein 3HCDH_N PF02737.18 ADV24001.1 - 3.4e-53 180.2 0.2 5.2e-53 179.6 0.2 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 ADV24001.1 - 1.2e-13 51.5 0.0 1.4e-12 48.0 0.0 2.2 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain NAD_Gly3P_dh_N PF01210.23 ADV24001.1 - 0.0037 17.2 0.1 0.0072 16.3 0.1 1.5 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_binding_2 PF03446.15 ADV24001.1 - 0.05 13.8 2.9 0.7 10.0 2.9 2.4 1 1 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase OspD PF03207.13 ADV24001.1 - 0.075 12.4 2.3 0.085 12.2 1.1 1.6 1 1 1 2 2 2 0 Borrelia outer surface protein D (OspD) F420_oxidored PF03807.17 ADV24001.1 - 2.5 8.7 5.7 8.5 7.0 0.1 2.6 1 1 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Snf7 PF03357.21 ADV24002.1 - 2.5e-21 76.0 6.7 4.8e-21 75.1 6.7 1.4 1 0 0 1 1 1 1 Snf7 Ribosomal_L7Ae PF01248.26 ADV24002.1 - 0.021 14.5 0.2 0.048 13.4 0.2 1.5 1 0 0 1 1 1 0 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Pet127 PF08634.10 ADV24002.1 - 0.065 12.7 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial protein Pet127 MutS_III PF05192.18 ADV24002.1 - 0.22 11.7 4.6 0.84 9.8 0.5 2.3 2 0 0 2 2 2 0 MutS domain III Tweety PF04906.13 ADV24002.1 - 0.26 9.9 2.1 0.38 9.4 1.7 1.4 1 1 0 1 1 1 0 Tweety PMI_typeI PF01238.21 ADV24003.1 - 4.3e-114 381.6 0.0 5.9e-114 381.1 0.0 1.2 1 0 0 1 1 1 1 Phosphomannose isomerase type I Cupin_2 PF07883.11 ADV24003.1 - 0.014 15.1 0.1 5 6.9 0.2 2.3 2 0 0 2 2 2 0 Cupin domain Herpes_BLRF2 PF05812.12 ADV24003.1 - 0.057 13.6 0.1 0.096 12.8 0.1 1.3 1 0 0 1 1 1 0 Herpesvirus BLRF2 protein Oxidored_FMN PF00724.20 ADV24004.1 - 5.5e-91 305.4 0.0 6.4e-91 305.2 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family AP_endonuc_2 PF01261.24 ADV24004.1 - 0.022 14.2 0.0 5 6.5 0.0 2.2 1 1 1 2 2 2 0 Xylose isomerase-like TIM barrel RCC1 PF00415.18 ADV24005.1 - 4.2e-32 110.5 6.7 1.6e-10 41.4 0.0 6.1 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ADV24005.1 - 7.4e-20 70.2 12.0 8.1e-07 28.7 0.1 4.7 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat PHD PF00628.29 ADV24005.1 - 4.9e-11 42.4 5.4 8.3e-11 41.6 5.4 1.4 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.6 ADV24005.1 - 0.12 12.6 0.2 0.26 11.6 0.2 1.4 1 0 0 1 1 1 0 PHD-like zinc-binding domain Zf_RING PF16744.5 ADV24005.1 - 1.3 9.2 4.8 2.8 8.1 4.8 1.6 1 1 0 1 1 1 0 KIAA1045 RING finger NAD_kinase PF01513.21 ADV24006.1 - 3.9e-71 239.6 0.0 2e-70 237.3 0.0 2.1 1 1 0 1 1 1 1 ATP-NAD kinase SelP_N PF04592.14 ADV24006.1 - 0.11 11.9 18.1 0.25 10.7 18.1 1.5 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DAGK_cat PF00781.24 ADV24006.1 - 0.12 12.0 0.0 0.31 10.7 0.0 1.6 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain MFMR_assoc PF16596.5 ADV24006.1 - 0.46 11.0 4.7 3.2 8.2 0.0 2.8 2 0 0 2 2 2 0 Disordered region downstream of MFMR KBP_C PF12309.8 ADV24006.1 - 0.48 9.9 5.3 0.82 9.1 5.3 1.3 1 0 0 1 1 1 0 KIF-1 binding protein C terminal Zip PF02535.22 ADV24006.1 - 7.1 5.7 12.8 15 4.7 12.8 1.5 1 0 0 1 1 1 0 ZIP Zinc transporter MDFI PF15316.6 ADV24007.1 - 0.076 13.1 2.7 0.1 12.6 1.9 1.6 1 1 0 1 1 1 0 MyoD family inhibitor PAC3 PF10178.9 ADV24008.1 - 0.0047 17.0 0.0 0.0096 16.1 0.0 1.5 1 0 0 1 1 1 1 Proteasome assembly chaperone 3 fn3_2 PF16893.5 ADV24009.1 - 2e-31 108.0 0.0 4.5e-31 106.8 0.0 1.6 1 0 0 1 1 1 1 Fibronectin type III domain CHS5_N PF16892.5 ADV24009.1 - 2.6e-22 78.5 0.2 5.3e-22 77.5 0.2 1.5 1 0 0 1 1 1 1 Chitin biosynthesis protein CHS5 N-terminus BRCT PF00533.26 ADV24009.1 - 0.00017 21.9 0.0 0.00041 20.7 0.0 1.7 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 ADV24009.1 - 0.0015 18.4 0.0 0.0041 17.0 0.0 1.8 1 1 0 1 1 1 1 twin BRCT domain fn3 PF00041.21 ADV24009.1 - 0.04 14.3 0.2 0.15 12.5 0.2 2.0 1 0 0 1 1 1 0 Fibronectin type III domain ATG22 PF11700.8 ADV24011.1 - 2.6e-45 155.0 0.1 3.2e-45 154.6 0.1 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like Bacillus_PapR PF05968.11 ADV24011.1 - 0.061 13.2 0.0 0.23 11.4 0.0 2.0 1 0 0 1 1 1 0 Bacillus PapR protein ATG22 PF11700.8 ADV24012.1 - 4.2e-53 180.6 7.7 4.8e-53 180.5 7.7 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like MFS_1 PF07690.16 ADV24012.1 - 4e-08 32.6 6.5 4.7e-08 32.3 6.5 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily TssN PF17555.2 ADV24012.1 - 0.019 14.4 3.2 0.021 14.2 3.2 1.2 1 0 0 1 1 1 0 Type VI secretion system, TssN LigB PF02900.18 ADV24013.1 - 1.7e-35 122.5 0.0 2.5e-35 121.9 0.0 1.1 1 0 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase Nop14 PF04147.12 ADV24014.1 - 3 5.9 11.9 4 5.5 11.9 1.0 1 0 0 1 1 1 0 Nop14-like family RRM_1 PF00076.22 ADV24017.1 - 1.4e-16 60.0 0.0 2.2e-16 59.4 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ADV24017.1 - 0.013 15.1 0.0 0.026 14.1 0.0 1.5 1 1 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ADV24017.1 - 0.079 12.8 0.0 0.37 10.7 0.0 2.0 1 1 0 1 1 1 0 Occluded RNA-recognition motif Exo84_C PF16528.5 ADV24018.1 - 4.1e-51 173.7 0.4 4.1e-51 173.7 0.4 1.7 2 0 0 2 2 2 1 Exocyst component 84 C-terminal Vps51 PF08700.11 ADV24018.1 - 1.3e-14 54.0 0.9 3.3e-14 52.7 0.9 1.8 1 0 0 1 1 1 1 Vps51/Vps67 Sec3-PIP2_bind PF15277.6 ADV24018.1 - 0.015 15.4 0.1 0.36 11.0 0.0 2.9 2 1 0 2 2 2 0 Exocyst complex component SEC3 N-terminal PIP2 binding PH PH_13 PF16652.5 ADV24018.1 - 0.022 14.6 0.4 0.078 12.8 0.0 2.0 2 0 0 2 2 2 0 Pleckstrin homology domain IQ_SEC7_PH PF16453.5 ADV24018.1 - 0.069 13.1 0.6 0.26 11.3 0.1 2.2 2 1 0 2 2 2 0 PH domain DUF3499 PF12005.8 ADV24018.1 - 0.72 10.5 2.0 1.9 9.1 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3499) RRM_1 PF00076.22 ADV24019.1 - 0.011 15.6 0.1 0.1 12.4 0.0 2.3 2 1 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Sec10 PF07393.11 ADV24020.1 - 4.7e-173 577.4 0.0 5.6e-173 577.1 0.0 1.0 1 0 0 1 1 1 1 Exocyst complex component Sec10 F-box PF00646.33 ADV24020.1 - 7.2e-06 25.8 0.1 3.8e-05 23.4 0.1 2.3 2 0 0 2 2 2 1 F-box domain DUF5102 PF17104.5 ADV24020.1 - 0.00022 21.4 0.6 0.00064 19.8 0.6 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF5102) F-box-like PF12937.7 ADV24020.1 - 0.0084 16.0 0.8 0.025 14.5 0.2 2.0 2 0 0 2 2 2 1 F-box-like MR_MLE_C PF13378.6 ADV24021.1 - 1.7e-53 181.4 0.0 2.4e-53 180.9 0.0 1.2 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 ADV24021.1 - 1.9e-23 82.9 0.0 3.6e-23 82.0 0.0 1.4 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain DHDPS PF00701.22 ADV24022.1 - 1.8e-27 95.8 0.0 1.6e-26 92.7 0.0 1.9 1 1 0 1 1 1 1 Dihydrodipicolinate synthetase family AA_kinase PF00696.28 ADV24023.1 - 2.2e-34 119.1 0.3 1e-32 113.7 0.3 2.8 1 1 0 1 1 1 1 Amino acid kinase family ACT_7 PF13840.6 ADV24023.1 - 9.9e-11 41.3 3.2 3.1e-06 26.9 0.6 2.7 2 0 0 2 2 2 2 ACT domain ACT PF01842.25 ADV24023.1 - 2.9e-08 33.3 1.2 4.2e-05 23.2 0.1 2.7 2 0 0 2 2 2 2 ACT domain Birna_VP2 PF01766.17 ADV24023.1 - 0.013 14.6 0.2 0.018 14.1 0.2 1.1 1 0 0 1 1 1 0 Birnavirus VP2 protein Acyltransferase PF01553.21 ADV24024.1 - 1.4e-17 63.6 0.0 2.4e-17 62.8 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase IFT46_B_C PF12317.8 ADV24024.1 - 0.0035 17.1 0.1 0.0056 16.4 0.1 1.3 1 0 0 1 1 1 1 Intraflagellar transport complex B protein 46 C terminal DUF2177 PF09945.9 ADV24024.1 - 0.054 13.6 1.6 0.11 12.6 1.6 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2177) GDPD PF03009.17 ADV24025.1 - 3.8e-33 115.3 0.0 4.9e-24 85.4 0.0 2.2 2 0 0 2 2 2 2 Glycerophosphoryl diester phosphodiesterase family GDPD_2 PF13653.6 ADV24025.1 - 3.1e-05 24.3 0.3 0.00026 21.3 0.8 2.2 2 0 0 2 2 2 1 Glycerophosphoryl diester phosphodiesterase family bZIP_1 PF00170.21 ADV24026.1 - 1.9e-06 27.8 4.4 1.9e-06 27.8 4.4 2.4 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 ADV24026.1 - 7.5e-06 25.9 5.6 7.5e-06 25.9 5.6 2.5 2 0 0 2 2 2 1 Basic region leucine zipper GATA PF00320.27 ADV24026.1 - 0.00024 20.6 0.3 0.00047 19.7 0.3 1.5 1 0 0 1 1 1 1 GATA zinc finger bZIP_Maf PF03131.17 ADV24026.1 - 0.00099 19.6 1.4 0.00099 19.6 1.4 3.4 4 0 0 4 4 4 1 bZIP Maf transcription factor zf-CpG_bind_C PF12269.8 ADV24026.1 - 0.82 9.4 2.4 2 8.2 2.4 1.6 1 0 0 1 1 1 0 CpG binding protein zinc finger C terminal domain zf-C3HC4_2 PF13923.6 ADV24027.1 - 6.4e-10 38.7 5.4 6.4e-10 38.7 5.4 4.0 4 1 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) zf-TRAF PF02176.18 ADV24027.1 - 1.2e-08 35.5 15.2 0.00014 22.4 1.5 3.5 2 1 1 3 3 3 2 TRAF-type zinc finger zf-TRAF_2 PF15965.5 ADV24027.1 - 1.4e-07 31.9 22.5 0.00075 19.9 4.3 2.6 1 1 0 2 2 2 2 TRAF-like zinc-finger zf-C3HC4 PF00097.25 ADV24027.1 - 1.5e-07 31.1 6.3 1.5e-07 31.1 6.3 3.0 2 1 1 3 3 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ADV24027.1 - 2.7e-06 27.6 5.3 2.7e-06 27.6 5.3 3.3 4 0 0 4 4 2 1 Ring finger domain zf-RING_5 PF14634.6 ADV24027.1 - 3.5e-05 23.7 4.3 3.5e-05 23.7 4.3 3.1 2 1 1 3 3 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 ADV24027.1 - 3.7e-05 23.7 5.4 3.7e-05 23.7 5.4 2.4 2 0 0 2 2 1 1 RING-type zinc-finger zf-Nse PF11789.8 ADV24027.1 - 7.1e-05 22.5 2.4 7.1e-05 22.5 2.4 2.4 3 0 0 3 3 2 1 Zinc-finger of the MIZ type in Nse subunit zf-rbx1 PF12678.7 ADV24027.1 - 0.0001 22.5 3.4 0.0001 22.5 3.4 2.8 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 ADV24027.1 - 0.0001 22.0 2.5 0.0001 22.0 2.5 3.1 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_10 PF16685.5 ADV24027.1 - 0.00087 19.4 1.6 0.00087 19.4 1.6 2.4 2 0 0 2 2 1 1 zinc RING finger of MSL2 zf-ACC PF17848.1 ADV24027.1 - 0.00093 19.2 0.5 0.41 10.8 0.0 3.7 3 0 0 3 3 3 1 Acetyl-coA carboxylase zinc finger domain Prok-RING_4 PF14447.6 ADV24027.1 - 0.006 16.4 3.6 0.006 16.4 3.6 2.9 2 1 1 3 3 2 1 Prokaryotic RING finger family 4 zf-RING_6 PF14835.6 ADV24027.1 - 0.0081 16.0 0.5 0.025 14.4 0.5 1.8 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-U11-48K PF05253.12 ADV24027.1 - 0.0086 16.0 0.4 0.24 11.4 0.0 3.6 3 0 0 3 3 3 1 U11-48K-like CHHC zinc finger CENP-Q PF13094.6 ADV24027.1 - 0.01 16.1 0.0 0.026 14.7 0.0 1.7 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit U-box PF04564.15 ADV24027.1 - 0.024 14.8 0.1 0.13 12.4 0.1 2.3 2 0 0 2 2 1 0 U-box domain DUF2637 PF10935.8 ADV24027.1 - 0.038 13.9 0.0 0.068 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2637) Sina PF03145.16 ADV24027.1 - 0.097 12.6 0.2 0.097 12.6 0.2 3.1 2 1 1 3 3 3 0 Seven in absentia protein family XhlA PF10779.9 ADV24027.1 - 0.13 12.5 0.1 0.25 11.6 0.1 1.4 1 0 0 1 1 1 0 Haemolysin XhlA JIP_LZII PF16471.5 ADV24027.1 - 0.32 11.2 4.2 0.12 12.6 1.4 1.7 2 0 0 2 2 1 0 JNK-interacting protein leucine zipper II zf-HC2 PF13490.6 ADV24027.1 - 0.45 10.8 5.1 16 5.9 0.0 3.4 3 0 0 3 3 3 0 Putative zinc-finger zf-C3HC4_4 PF15227.6 ADV24027.1 - 0.79 9.9 13.1 0.034 14.3 3.6 2.9 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING SPX PF03105.19 ADV24027.1 - 5.4 6.8 8.9 19 5.0 0.0 2.2 2 0 0 2 2 2 0 SPX domain Hexapep PF00132.24 ADV24028.1 - 6e-07 28.9 3.7 0.00091 18.9 1.2 3.0 1 1 3 4 4 4 4 Bacterial transferase hexapeptide (six repeats) NTP_transferase PF00483.23 ADV24028.1 - 1.2e-05 25.1 0.0 5e-05 23.0 0.0 2.0 3 0 0 3 3 3 1 Nucleotidyl transferase DUF4954 PF16314.5 ADV24028.1 - 0.00016 20.0 1.1 0.00061 18.1 0.6 1.8 1 1 1 2 2 2 1 Domain of unknown function (DUF4954) Fucokinase PF07959.12 ADV24028.1 - 0.0026 16.8 0.1 0.37 9.7 0.0 2.1 1 1 1 2 2 2 2 L-fucokinase NTP_transf_3 PF12804.7 ADV24028.1 - 0.026 14.9 0.0 0.063 13.6 0.0 1.8 1 1 0 1 1 1 0 MobA-like NTP transferase domain CTP_transf_3 PF02348.19 ADV24028.1 - 0.17 11.8 0.0 0.32 10.9 0.0 1.4 1 0 0 1 1 1 0 Cytidylyltransferase Arf PF00025.21 ADV24029.1 - 3.8e-55 186.0 0.0 4.5e-55 185.8 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 ADV24029.1 - 2.9e-10 40.0 0.0 3.4e-10 39.8 0.0 1.0 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 ADV24029.1 - 3.2e-10 39.7 0.0 3.8e-10 39.5 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 ADV24029.1 - 8.4e-10 38.3 0.1 1.5e-06 27.7 0.0 2.1 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.13 ADV24029.1 - 1.7e-08 34.7 0.0 2.4e-08 34.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 ADV24029.1 - 2.5e-07 30.7 0.0 3.7e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ADV24029.1 - 3.4e-06 26.7 0.0 8.7e-05 22.1 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 ADV24029.1 - 0.00027 20.3 0.0 0.00035 20.0 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region FeoB_N PF02421.18 ADV24029.1 - 0.0065 16.0 0.1 0.0095 15.5 0.1 1.5 1 1 0 1 1 1 1 Ferrous iron transport protein B MeaB PF03308.16 ADV24029.1 - 0.075 12.0 0.0 0.86 8.5 0.0 2.0 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_29 PF13555.6 ADV24029.1 - 0.13 12.0 0.0 0.28 11.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Peptidase_C78 PF07910.13 ADV24030.1 - 5.6e-35 120.7 0.0 1.1e-34 119.7 0.0 1.5 1 0 0 1 1 1 1 Peptidase family C78 Zn-C2H2_12 PF18112.1 ADV24030.1 - 0.0015 18.9 0.2 0.0015 18.9 0.2 2.6 2 0 0 2 2 2 1 Autophagy receptor zinc finger-C2H2 domain zf-C2H2_9 PF16293.5 ADV24030.1 - 0.13 12.1 1.9 0.59 10.0 0.1 2.4 2 0 0 2 2 2 0 C2H2 type zinc-finger (1 copy) zf-Di19 PF05605.12 ADV24030.1 - 0.14 12.5 1.7 5.6 7.3 0.1 2.4 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding UBZ_FAAP20 PF15750.5 ADV24030.1 - 0.17 11.8 5.6 0.054 13.4 2.1 2.0 2 0 0 2 2 2 0 Ubiquitin-binding zinc-finger BTB PF00651.31 ADV24031.1 - 2.8e-11 43.6 0.0 1.8e-05 24.9 0.0 2.6 2 0 0 2 2 2 2 BTB/POZ domain SPA PF08616.10 ADV24032.1 - 3.4e-10 39.9 0.0 5.7e-10 39.2 0.0 1.3 1 0 0 1 1 1 1 Stabilization of polarity axis Peptidase_C65 PF10275.9 ADV24033.1 - 3.2e-75 252.8 0.0 3.8e-75 252.5 0.0 1.0 1 0 0 1 1 1 1 Peptidase C65 Otubain OTU PF02338.19 ADV24033.1 - 1.5e-05 25.5 0.0 0.0025 18.3 0.0 2.3 2 0 0 2 2 2 2 OTU-like cysteine protease MFS_1 PF07690.16 ADV24034.1 - 2.5e-22 79.3 35.3 2.5e-17 62.8 11.5 2.4 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ADV24034.1 - 3.6e-08 32.7 3.2 3.6e-08 32.7 3.2 2.3 2 0 0 2 2 2 2 Sugar (and other) transporter Na_trans_assoc PF06512.13 ADV24034.1 - 0.31 11.3 1.4 5.7 7.2 1.2 2.1 2 0 0 2 2 2 0 Sodium ion transport-associated MFS_1_like PF12832.7 ADV24034.1 - 1.5 7.6 19.2 0.13 11.0 0.4 3.2 2 1 0 3 3 3 0 MFS_1 like family DOCK_N PF16172.5 ADV24035.1 - 8.7e-101 337.6 0.0 3.7e-100 335.5 0.0 1.9 2 0 0 2 2 2 1 DOCK N-terminus DOCK-C2 PF14429.6 ADV24035.1 - 6.7e-42 143.5 0.2 3.1e-41 141.3 0.0 2.1 2 0 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins DHR-2 PF06920.13 ADV24035.1 - 3.3e-28 98.6 0.0 2.2e-26 92.6 0.0 2.6 2 1 0 2 2 2 2 Dock homology region 2 TPX2 PF06886.11 ADV24036.1 - 5.7e-11 42.5 19.3 5.7e-11 42.5 19.3 2.4 2 0 0 2 2 2 1 Targeting protein for Xklp2 (TPX2) ABM PF03992.16 ADV24037.1 - 5.7e-08 32.8 0.1 7.2e-08 32.4 0.1 1.1 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase BetaGal_dom2 PF10435.9 ADV24037.1 - 0.045 13.6 0.0 0.054 13.3 0.0 1.1 1 0 0 1 1 1 0 Beta-galactosidase, domain 2 Ycf54 PF10674.9 ADV24037.1 - 0.063 13.6 0.3 0.088 13.1 0.3 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2488) Sld3_N PF18523.1 ADV24037.1 - 0.07 13.3 0.5 0.18 11.9 0.5 1.8 1 1 0 1 1 1 0 Sld3 N-terminal domain Helo_like_N PF17111.5 ADV24037.1 - 0.074 12.4 0.1 0.092 12.1 0.1 1.1 1 0 0 1 1 1 0 Fungal N-terminal domain of STAND proteins TIR PF01582.20 ADV24037.1 - 0.08 12.7 0.2 0.09 12.6 0.2 1.1 1 0 0 1 1 1 0 TIR domain Put_Phosphatase PF06888.12 ADV24038.1 - 1.5e-47 162.0 0.0 1.7e-47 161.8 0.0 1.0 1 0 0 1 1 1 1 Putative Phosphatase HAD PF12710.7 ADV24038.1 - 2.6e-07 31.2 0.1 8.9e-07 29.5 0.1 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase RE_CfrBI PF09516.10 ADV24038.1 - 0.067 12.6 0.0 0.092 12.2 0.0 1.2 1 0 0 1 1 1 0 CfrBI restriction endonuclease FmiP_Thoc5 PF09766.9 ADV24039.1 - 2.7e-14 53.2 1.9 3.3e-14 53.0 1.9 1.1 1 0 0 1 1 1 1 Fms-interacting protein/Thoc5 HK PF02110.15 ADV24041.1 - 6.6e-72 241.8 1.7 3.4e-70 236.2 1.7 2.3 1 1 0 1 1 1 1 Hydroxyethylthiazole kinase family TMP-TENI PF02581.17 ADV24041.1 - 3.6e-56 189.3 0.5 2.4e-53 180.2 0.1 2.3 2 0 0 2 2 2 2 Thiamine monophosphate synthase Phos_pyr_kin PF08543.12 ADV24041.1 - 0.0012 18.3 0.1 0.0071 15.7 0.0 2.2 2 1 0 2 2 2 1 Phosphomethylpyrimidine kinase Carb_kinase PF01256.17 ADV24041.1 - 0.0032 17.0 0.1 0.0066 15.9 0.1 1.5 1 1 0 1 1 1 1 Carbohydrate kinase Pox_A_type_inc PF04508.12 ADV24042.1 - 0.75 9.7 20.1 3.4 7.7 0.1 7.9 7 0 0 7 7 7 0 Viral A-type inclusion protein repeat UPF0147 PF03685.13 ADV24042.1 - 0.84 9.7 6.7 5.7 7.1 0.5 4.9 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0147) DUF1479 PF07350.12 ADV24043.1 - 2.8e-155 517.2 0.0 3.2e-155 517.0 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1479) Tnp_DNA_bind PF14706.6 ADV24043.1 - 0.096 12.6 0.0 0.26 11.2 0.0 1.7 1 0 0 1 1 1 0 Transposase DNA-binding Ku PF02735.16 ADV24044.1 - 3.7e-34 118.2 1.5 5.5e-32 111.1 1.5 2.3 1 1 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.15 ADV24044.1 - 1.9e-20 73.5 0.0 1.9e-18 67.1 0.0 2.6 2 1 0 2 2 2 1 Ku70/Ku80 N-terminal alpha/beta domain Ku_C PF03730.14 ADV24044.1 - 6.5e-15 55.6 1.0 6.5e-15 55.6 1.0 3.6 3 1 0 3 3 3 1 Ku70/Ku80 C-terminal arm Seryl_tRNA_N PF02403.22 ADV24044.1 - 0.0069 16.6 3.5 0.0069 16.6 3.5 2.6 3 0 0 3 3 3 1 Seryl-tRNA synthetase N-terminal domain VWA_2 PF13519.6 ADV24044.1 - 0.027 15.1 0.0 0.5 11.0 0.0 2.7 1 1 1 2 2 2 0 von Willebrand factor type A domain Vma12 PF11712.8 ADV24045.1 - 1.2e-11 44.8 0.0 4e-11 43.1 0.0 1.8 1 1 0 1 1 1 1 Endoplasmic reticulum-based factor for assembly of V-ATPase LIM PF00412.22 ADV24046.1 - 0.016 15.4 0.2 0.016 15.4 0.2 1.7 2 0 0 2 2 2 0 LIM domain DZR PF12773.7 ADV24046.1 - 0.022 14.8 1.7 0.18 11.9 1.9 2.0 1 1 0 1 1 1 0 Double zinc ribbon zf-C2HC5 PF06221.13 ADV24046.1 - 0.24 11.4 3.5 0.24 11.4 0.4 2.1 1 1 1 2 2 2 0 Putative zinc finger motif, C2HC5-type TF_Zn_Ribbon PF08271.12 ADV24046.1 - 1 8.9 4.7 0.91 9.1 0.1 2.6 3 0 0 3 3 3 0 TFIIB zinc-binding DNA_RNApol_7kD PF03604.13 ADV24046.1 - 4 7.2 7.3 21 4.9 0.2 3.1 3 0 0 3 3 3 0 DNA directed RNA polymerase, 7 kDa subunit RhoGAP PF00620.27 ADV24047.1 - 3.4e-45 153.6 0.0 6.5e-45 152.7 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain C1_1 PF00130.22 ADV24047.1 - 2.8e-08 33.5 9.2 4.2e-08 33.0 9.2 1.3 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF4407 PF14362.6 ADV24047.1 - 0.00022 20.7 11.0 0.0008 18.9 4.5 2.1 1 1 1 2 2 2 1 Domain of unknown function (DUF4407) Baculo_PEP_C PF04513.12 ADV24047.1 - 0.0041 17.2 3.8 0.011 15.8 1.8 2.5 1 1 1 2 2 2 1 Baculovirus polyhedron envelope protein, PEP, C terminus Ribosomal_L37e PF01907.19 ADV24047.1 - 0.018 15.2 3.3 0.036 14.2 3.3 1.5 1 0 0 1 1 1 0 Ribosomal protein L37e DUF4686 PF15742.5 ADV24047.1 - 0.028 13.5 15.0 0.45 9.6 15.1 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4686) Fez1 PF06818.15 ADV24047.1 - 0.031 14.7 18.0 0.19 12.2 8.0 2.4 1 1 1 2 2 2 0 Fez1 KASH_CCD PF14662.6 ADV24047.1 - 0.032 14.1 18.9 0.19 11.6 4.4 3.3 2 1 1 3 3 3 0 Coiled-coil region of CCDC155 or KASH Spc7 PF08317.11 ADV24047.1 - 0.039 12.8 18.7 0.12 11.2 5.3 2.2 2 0 0 2 2 2 0 Spc7 kinetochore protein Sec8_exocyst PF04048.14 ADV24047.1 - 0.12 12.3 0.9 0.46 10.4 0.9 1.9 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain APG6_N PF17675.1 ADV24047.1 - 0.13 12.8 25.3 0.17 12.5 7.8 3.3 2 1 0 2 2 2 0 Apg6 coiled-coil region YabA PF06156.13 ADV24047.1 - 0.13 12.9 9.8 0.077 13.6 2.0 3.2 2 1 2 4 4 4 0 Initiation control protein YabA FlxA PF14282.6 ADV24047.1 - 0.16 12.0 10.3 2.4 8.2 0.2 3.0 2 1 0 2 2 2 0 FlxA-like protein CENP-H PF05837.12 ADV24047.1 - 0.19 12.1 17.0 1.1 9.7 0.6 3.4 3 0 0 3 3 3 0 Centromere protein H (CENP-H) CorA PF01544.18 ADV24047.1 - 0.2 10.9 14.3 0.062 12.6 3.4 2.6 2 1 1 3 3 3 0 CorA-like Mg2+ transporter protein TMF_TATA_bd PF12325.8 ADV24047.1 - 0.22 11.8 23.8 0.061 13.6 5.7 3.8 4 0 0 4 4 4 0 TATA element modulatory factor 1 TATA binding C1_2 PF03107.16 ADV24047.1 - 0.23 11.8 4.7 0.41 11.0 4.7 1.4 1 0 0 1 1 1 0 C1 domain TolA_bind_tri PF16331.5 ADV24047.1 - 0.3 11.2 18.5 0.37 10.9 1.1 4.2 2 2 1 3 3 3 0 TolA binding protein trimerisation Seryl_tRNA_N PF02403.22 ADV24047.1 - 0.36 11.1 18.7 0.85 9.9 3.7 3.2 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Filament PF00038.21 ADV24047.1 - 0.47 10.0 19.1 1.8 8.0 19.1 2.0 1 1 0 1 1 1 0 Intermediate filament protein OmpH PF03938.14 ADV24047.1 - 0.55 10.6 11.0 0.65 10.3 1.2 2.6 2 1 0 2 2 2 0 Outer membrane protein (OmpH-like) PHD PF00628.29 ADV24047.1 - 0.68 9.9 5.7 1.2 9.1 5.7 1.3 1 0 0 1 1 1 0 PHD-finger FUSC PF04632.12 ADV24047.1 - 0.92 8.0 8.2 1.5 7.3 8.2 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family NPV_P10 PF05531.12 ADV24047.1 - 1 9.8 3.3 28 5.3 2.1 3.6 3 1 0 3 3 2 0 Nucleopolyhedrovirus P10 protein CENP-F_leu_zip PF10473.9 ADV24047.1 - 1.2 9.1 19.1 2.2 8.3 5.1 3.2 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Jnk-SapK_ap_N PF09744.9 ADV24047.1 - 1.4 9.1 20.7 10 6.3 5.1 2.6 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 AIP3 PF03915.13 ADV24047.1 - 1.5 7.8 10.0 5.8 5.9 10.0 1.8 1 1 0 1 1 1 0 Actin interacting protein 3 FAM184 PF15665.5 ADV24047.1 - 1.8 8.3 16.7 3.4 7.4 5.3 2.3 2 0 0 2 2 2 0 Family with sequence similarity 184, A and B Prok-RING_1 PF14446.6 ADV24047.1 - 2.1 8.4 6.1 3.8 7.5 6.1 1.3 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 GAS PF13851.6 ADV24047.1 - 2.3 7.5 18.7 1.3 8.3 6.7 2.3 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding DUF724 PF05266.14 ADV24047.1 - 2.4 8.0 10.3 4.9 6.9 2.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF724) Fib_alpha PF08702.10 ADV24047.1 - 2.6 8.2 6.1 3.1 8.0 0.9 2.4 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family HemX PF04375.14 ADV24047.1 - 2.9 7.1 14.3 1.2 8.3 4.0 2.4 2 1 0 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase Lzipper-MIP1 PF14389.6 ADV24047.1 - 3.5 8.0 12.6 0.17 12.2 1.4 3.6 2 2 2 4 4 3 0 Leucine-zipper of ternary complex factor MIP1 LUC7 PF03194.15 ADV24047.1 - 4 7.0 6.8 5.9 6.5 0.0 2.4 2 1 0 2 2 2 0 LUC7 N_terminus ABC_tran_CTD PF16326.5 ADV24047.1 - 4.2 7.7 19.0 2.3 8.6 10.0 3.2 2 1 0 2 2 2 0 ABC transporter C-terminal domain DUF2353 PF09789.9 ADV24047.1 - 4.9 6.4 13.4 1.3 8.3 1.8 2.4 2 0 0 2 2 2 0 Uncharacterized coiled-coil protein (DUF2353) Phage_GP20 PF06810.11 ADV24047.1 - 6.3 6.6 9.1 13 5.5 2.8 2.7 2 1 0 2 2 2 0 Phage minor structural protein GP20 Cnn_1N PF07989.11 ADV24047.1 - 7.8 6.7 11.7 3.5 7.9 3.1 3.3 2 1 1 3 3 3 0 Centrosomin N-terminal motif 1 DUF4200 PF13863.6 ADV24047.1 - 8.3 6.8 21.5 1.5 9.2 1.8 4.4 2 2 2 4 4 4 0 Domain of unknown function (DUF4200) Csm1_N PF18504.1 ADV24047.1 - 8.5 6.8 13.4 12 6.4 1.2 4.2 3 1 1 4 4 4 0 Csm1 N-terminal domain Taxilin PF09728.9 ADV24047.1 - 8.5 5.5 13.0 0.49 9.5 1.5 2.3 2 0 0 2 2 2 0 Myosin-like coiled-coil protein TAP_C PF03943.13 ADV24048.1 - 2.1e-17 62.5 0.1 5e-17 61.3 0.0 1.7 2 0 0 2 2 2 1 TAP C-terminal domain UBA_4 PF14555.6 ADV24048.1 - 0.084 12.7 0.1 0.15 11.9 0.1 1.4 1 0 0 1 1 1 0 UBA-like domain NTF2 PF02136.20 ADV24048.1 - 0.14 12.7 0.0 0.57 10.8 0.0 1.9 2 0 0 2 2 2 0 Nuclear transport factor 2 (NTF2) domain LRR_4 PF12799.7 ADV24048.1 - 0.54 10.8 3.4 1.8 9.1 1.6 2.4 2 0 0 2 2 2 0 Leucine Rich repeats (2 copies) Josephin PF02099.17 ADV24049.1 - 1.9e-47 161.4 0.0 3.1e-47 160.7 0.0 1.3 1 0 0 1 1 1 1 Josephin UIM PF02809.20 ADV24049.1 - 0.08 12.9 5.7 0.14 12.1 4.2 2.2 2 0 0 2 2 2 0 Ubiquitin interaction motif SSP160 PF06933.11 ADV24049.1 - 3 5.9 5.3 4.9 5.2 5.3 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Spt4 PF06093.13 ADV24051.1 - 2.2e-31 107.7 0.2 2.7e-31 107.5 0.2 1.1 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger Coronavirus_5 PF05528.11 ADV24051.1 - 0.13 12.2 0.0 0.26 11.3 0.0 1.6 1 1 0 1 1 1 0 Coronavirus gene 5 protein Fe_hyd_lg_C PF02906.14 ADV24052.1 - 7.6e-53 179.7 0.0 1.6e-52 178.6 0.0 1.5 1 0 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain C2 PF00168.30 ADV24053.1 - 5.2e-25 87.7 0.0 1.4e-12 47.8 0.0 3.0 3 0 0 3 3 3 2 C2 domain Methyltransf_24 PF13578.6 ADV24055.1 - 7.5e-05 23.7 0.1 0.00039 21.4 0.1 2.1 1 1 0 1 1 1 1 Methyltransferase domain Topoisom_I PF01028.20 ADV24056.1 - 6.4e-98 326.6 1.1 6.4e-98 326.6 1.1 2.1 2 0 0 2 2 2 1 Eukaryotic DNA topoisomerase I, catalytic core Topoisom_I_N PF02919.15 ADV24056.1 - 9.1e-92 306.4 2.5 9.1e-92 306.4 2.5 4.0 4 0 0 4 4 4 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topo_C_assoc PF14370.6 ADV24056.1 - 1.6e-32 111.2 0.2 5.9e-32 109.4 0.2 2.1 1 0 0 1 1 1 1 C-terminal topoisomerase domain GATase_5 PF13507.6 ADV24057.1 - 1.4e-95 319.3 0.0 2.5e-95 318.5 0.0 1.4 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain AIRS_C PF02769.22 ADV24057.1 - 9.2e-47 159.1 5.2 1.1e-31 110.0 0.2 2.3 2 0 0 2 2 2 2 AIR synthase related protein, C-terminal domain FGAR-AT_N PF18076.1 ADV24057.1 - 5.4e-31 107.0 0.0 1e-30 106.1 0.0 1.5 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase N-terminal FGAR-AT_linker PF18072.1 ADV24057.1 - 1.9e-21 76.3 0.0 6.6e-21 74.6 0.0 2.0 2 0 0 2 2 2 1 Formylglycinamide ribonucleotide amidotransferase linker domain SET PF00856.28 ADV24059.1 - 0.023 15.1 0.0 0.37 11.1 0.0 2.2 1 1 1 2 2 2 0 SET domain GWT1 PF06423.12 ADV24060.1 - 1.3e-38 132.5 0.0 1.2e-36 126.1 0.0 2.9 3 0 0 3 3 3 2 GWT1 FixP_N PF14715.6 ADV24061.1 - 2.6e-05 23.9 0.1 4.3e-05 23.2 0.1 1.3 1 0 0 1 1 1 1 N-terminal domain of cytochrome oxidase-cbb3, FixP DUF3094 PF11293.8 ADV24061.1 - 0.091 12.5 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3094) CrgA PF06781.12 ADV24061.1 - 1.2 9.3 0.0 1.2 9.3 0.0 2.2 2 0 0 2 2 2 0 Cell division protein CrgA HEAT PF02985.22 ADV24062.1 - 3e-09 36.4 2.9 0.076 13.3 0.1 6.1 7 0 0 7 7 7 2 HEAT repeat Cnd1 PF12717.7 ADV24062.1 - 5.7e-06 26.5 0.4 0.0019 18.3 0.0 2.5 2 0 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 ADV24062.1 - 0.0001 22.6 0.0 1.4 9.4 0.0 3.7 3 1 0 3 3 3 2 HEAT repeats HEAT_EZ PF13513.6 ADV24062.1 - 0.0019 18.7 3.3 1.2 9.7 0.1 4.3 6 0 0 6 6 6 2 HEAT-like repeat Pkinase PF00069.25 ADV24062.1 - 0.0084 15.5 0.0 0.034 13.5 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain VGCC_beta4Aa_N PF12052.8 ADV24062.1 - 0.067 13.3 1.0 0.16 12.1 1.0 1.6 1 0 0 1 1 1 0 Voltage gated calcium channel subunit beta domain 4Aa N terminal Vac14_Fab1_bd PF12755.7 ADV24062.1 - 0.16 12.6 0.0 1.1 9.9 0.0 2.4 2 1 1 3 3 3 0 Vacuolar 14 Fab1-binding region FAD_binding_2 PF00890.24 ADV24063.1 - 1e-125 420.1 4.6 1.3e-125 419.8 4.6 1.1 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 ADV24063.1 - 1.1e-43 148.3 0.5 1.6e-43 147.7 0.5 1.3 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term Pyr_redox_2 PF07992.14 ADV24063.1 - 4.6e-06 26.1 0.7 0.00069 18.9 0.2 2.4 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 ADV24063.1 - 1.4e-05 24.5 0.7 0.0098 15.2 0.1 2.4 2 0 0 2 2 2 2 Thi4 family GIDA PF01134.22 ADV24063.1 - 7.4e-05 22.0 1.7 0.035 13.2 2.8 2.3 2 0 0 2 2 2 2 Glucose inhibited division protein A Lycopene_cycl PF05834.12 ADV24063.1 - 0.0082 15.2 0.0 0.012 14.6 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_binding_3 PF01494.19 ADV24063.1 - 0.016 14.5 0.4 0.03 13.6 0.4 1.4 1 0 0 1 1 1 0 FAD binding domain HI0933_like PF03486.14 ADV24063.1 - 0.046 12.4 2.4 0.55 8.9 0.9 2.9 4 0 0 4 4 4 0 HI0933-like protein WD40 PF00400.32 ADV24064.1 - 1.1e-21 76.7 12.9 0.0024 18.7 0.4 6.9 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV24064.1 - 8.2e-10 38.9 2.0 0.019 15.3 0.1 4.6 3 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ADV24064.1 - 0.0001 21.4 0.0 1.4 7.8 0.0 4.0 2 1 2 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Methyltransf_3 PF01596.17 ADV24065.1 - 1.7e-29 102.5 0.0 2.4e-29 102.1 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 ADV24065.1 - 5.3e-14 53.1 0.0 8.4e-14 52.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 ADV24065.1 - 7.3e-06 25.9 0.0 1.1e-05 25.3 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 ADV24065.1 - 0.0084 15.9 0.0 0.013 15.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ADV24065.1 - 0.009 16.7 0.0 0.016 15.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain GCD14 PF08704.10 ADV24065.1 - 0.14 11.8 0.0 0.22 11.2 0.0 1.2 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit Methyltransf_11 PF08241.12 ADV24065.1 - 0.18 12.4 0.0 0.49 11.1 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain Actin PF00022.19 ADV24066.1 - 1.1e-114 383.2 0.0 5.2e-114 381.0 0.0 1.7 1 1 0 1 1 1 1 Actin GM_CSF PF01109.17 ADV24066.1 - 0.071 13.3 0.0 29 4.9 0.0 3.0 3 0 0 3 3 3 0 Granulocyte-macrophage colony-stimulating factor Pkinase PF00069.25 ADV24067.1 - 1.3e-52 178.7 0.4 3.2e-52 177.5 0.4 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV24067.1 - 4.4e-22 78.6 0.0 6.7e-22 78.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ADV24067.1 - 3e-05 24.1 1.6 0.00036 20.5 0.0 2.9 2 2 1 3 3 3 1 Phosphotransferase enzyme family RIO1 PF01163.22 ADV24067.1 - 0.005 16.5 0.2 0.016 14.8 0.1 1.8 2 0 0 2 2 2 1 RIO1 family Choline_kinase PF01633.20 ADV24067.1 - 0.011 15.3 2.4 0.045 13.3 0.6 2.3 2 0 0 2 2 2 0 Choline/ethanolamine kinase Bromodomain PF00439.25 ADV24071.1 - 6.8e-23 80.5 0.0 1.5e-22 79.5 0.0 1.5 1 0 0 1 1 1 1 Bromodomain CASP_C PF08172.12 ADV24072.1 - 3.4e-68 229.7 0.0 3.4e-68 229.7 0.0 4.1 2 2 0 3 3 3 1 CASP C terminal DUF1157 PF06636.11 ADV24072.1 - 0.13 11.1 0.1 0.21 10.4 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1157) Aldo_ket_red PF00248.21 ADV24073.1 - 4.8e-66 222.9 0.0 5.8e-66 222.7 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Sugar_tr PF00083.24 ADV24074.1 - 1.1e-78 265.2 16.3 1.3e-78 264.9 16.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ADV24074.1 - 1.5e-15 57.0 34.7 7e-11 41.6 24.8 2.5 1 1 2 3 3 3 2 Major Facilitator Superfamily MFS_1_like PF12832.7 ADV24074.1 - 0.00052 19.0 4.3 0.00052 19.0 4.3 1.9 2 0 0 2 2 2 1 MFS_1 like family DUF1690 PF07956.11 ADV24075.1 - 1.4e-28 100.1 0.0 1.7e-28 99.7 0.0 1.1 1 0 0 1 1 1 1 Protein of Unknown function (DUF1690) Rootletin PF15035.6 ADV24075.1 - 0.00036 20.6 0.8 0.00055 20.0 0.9 1.3 1 1 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion YscO PF07321.12 ADV24075.1 - 0.055 13.4 5.5 0.35 10.8 5.6 2.0 1 1 0 1 1 1 0 Type III secretion protein YscO ATP-sulfurylase PF01747.17 ADV24076.1 - 5.5e-87 290.7 0.1 7.7e-87 290.2 0.1 1.2 1 0 0 1 1 1 1 ATP-sulfurylase PUA_2 PF14306.6 ADV24076.1 - 5e-52 175.8 0.0 7.9e-52 175.1 0.0 1.3 1 0 0 1 1 1 1 PUA-like domain APS_kinase PF01583.20 ADV24076.1 - 4.1e-45 153.5 0.0 5.8e-45 153.0 0.0 1.2 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_18 PF13238.6 ADV24076.1 - 0.00045 20.8 0.0 0.00086 19.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 ADV24076.1 - 0.2 11.1 0.0 0.3 10.5 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 Peptidase_S9 PF00326.21 ADV24077.1 - 0.00025 20.6 0.0 0.00037 20.0 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.18 ADV24077.1 - 0.0018 17.8 0.0 0.0028 17.3 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family COesterase PF00135.28 ADV24077.1 - 0.042 12.7 0.0 0.057 12.3 0.0 1.1 1 0 0 1 1 1 0 Carboxylesterase family Abhydrolase_6 PF12697.7 ADV24077.1 - 0.066 13.8 0.0 0.29 11.7 0.0 1.9 1 1 0 1 1 1 0 Alpha/beta hydrolase family PEPCK_ATP PF01293.20 ADV24078.1 - 1.1e-217 723.3 0.0 1.2e-217 723.1 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase AAA_33 PF13671.6 ADV24078.1 - 0.0062 16.7 0.0 0.011 15.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 ADV24078.1 - 0.14 12.0 0.1 0.37 10.6 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 ADV24078.1 - 0.22 11.9 0.0 0.37 11.2 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain Glyoxalase PF00903.25 ADV24079.1 - 2.2e-18 66.7 0.1 4.7e-18 65.6 0.1 1.5 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 ADV24079.1 - 4.7e-06 26.8 0.0 8e-06 26.1 0.0 1.5 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.7 ADV24079.1 - 2.4e-05 24.3 0.1 0.0024 17.8 0.1 2.2 1 1 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_6 PF18029.1 ADV24079.1 - 0.0009 20.0 0.0 0.0014 19.4 0.0 1.3 1 1 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_3 PF13468.6 ADV24079.1 - 0.048 13.8 0.0 0.076 13.1 0.0 1.4 1 0 0 1 1 1 0 Glyoxalase-like domain 6PF2K PF01591.18 ADV24080.1 - 2.7e-67 226.3 0.0 4e-67 225.8 0.0 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 ADV24080.1 - 4.7e-37 127.6 0.0 9.6e-37 126.6 0.0 1.5 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 ADV24080.1 - 7.2e-05 23.0 0.0 0.00014 22.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 ADV24080.1 - 0.033 13.6 0.0 0.076 12.5 0.0 1.6 1 1 0 1 1 1 0 Chromatin associated protein KTI12 AAA_17 PF13207.6 ADV24080.1 - 0.085 13.3 0.0 0.15 12.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain GBP PF02263.19 ADV24080.1 - 0.11 11.7 0.0 0.19 11.0 0.0 1.3 1 0 0 1 1 1 0 Guanylate-binding protein, N-terminal domain SDA1 PF05285.12 ADV24081.1 - 2.7e-92 309.9 47.3 5.5e-91 305.6 37.5 2.1 2 0 0 2 2 2 2 SDA1 NUC130_3NT PF08158.12 ADV24081.1 - 5.1e-20 71.5 0.1 2.6e-19 69.3 0.0 2.3 2 0 0 2 2 2 1 NUC130/3NT domain SPATA1_C PF15743.5 ADV24081.1 - 0.012 15.7 8.1 0.012 15.7 8.1 3.4 3 0 0 3 3 3 0 Spermatogenesis-associated C-terminus CDC45 PF02724.14 ADV24081.1 - 0.025 12.9 0.0 0.025 12.9 0.0 2.9 2 1 0 2 2 2 0 CDC45-like protein NIF PF03031.18 ADV24082.1 - 4.2e-55 185.8 0.3 5.7e-55 185.4 0.3 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase SART-1 PF03343.13 ADV24083.1 - 2.8e-152 508.5 61.5 3.3e-152 508.3 61.5 1.0 1 0 0 1 1 1 1 SART-1 family G6B PF15096.6 ADV24083.1 - 6.9 6.4 6.5 6 6.6 0.2 3.2 2 2 1 3 3 3 0 G6B family adh_short_C2 PF13561.6 ADV24084.1 - 4.4e-48 163.9 0.0 8.6e-48 162.9 0.0 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ADV24084.1 - 3.6e-38 131.0 0.2 7.4e-38 130.0 0.0 1.5 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 ADV24084.1 - 5.4e-05 23.2 0.1 0.0026 17.7 0.1 2.3 1 1 0 1 1 1 1 KR domain PhyH PF05721.13 ADV24085.1 - 7.9e-48 163.5 0.0 9.7e-48 163.2 0.0 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DUF1852 PF08908.11 ADV24085.1 - 0.0065 15.5 0.0 0.0094 15.0 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1852) 2OG-FeII_Oxy_5 PF13759.6 ADV24085.1 - 0.082 13.3 0.0 0.25 11.8 0.0 1.8 2 0 0 2 2 2 0 Putative 2OG-Fe(II) oxygenase TetM_leader PF08076.11 ADV24085.1 - 0.13 12.1 0.7 0.32 10.8 0.7 1.6 1 0 0 1 1 1 0 Tetracycline resistance determinant leader peptide ANAPC4 PF12896.7 ADV24086.1 - 2.9e-33 115.1 0.1 4.7e-33 114.4 0.1 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 4 ANAPC4_WD40 PF12894.7 ADV24086.1 - 0.00083 19.6 0.6 0.0023 18.2 0.1 2.0 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain L51_S25_CI-B8 PF05047.16 ADV24088.1 - 8.9e-13 47.9 0.0 1.3e-12 47.4 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain adh_short_C2 PF13561.6 ADV24089.1 - 2.5e-49 168.0 0.0 3e-49 167.7 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ADV24089.1 - 5.6e-34 117.3 0.0 7.1e-34 117.0 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ADV24089.1 - 2.8e-08 33.9 0.0 3.9e-08 33.4 0.0 1.1 1 0 0 1 1 1 1 KR domain Cript PF10235.9 ADV24090.1 - 1.1e-19 70.8 11.8 8.5e-19 67.9 11.8 1.9 1 1 0 1 1 1 1 Microtubule-associated protein CRIPT DUF2039 PF10217.9 ADV24090.1 - 0.0029 17.9 7.4 0.0042 17.4 7.4 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2039) zinc_ribbon_2 PF13240.6 ADV24090.1 - 0.074 12.8 4.4 4.4 7.2 3.8 2.3 2 0 0 2 2 2 0 zinc-ribbon domain DUF3624 PF12292.8 ADV24090.1 - 0.62 10.5 4.4 0.85 10.1 4.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3624) DNA_RNApol_7kD PF03604.13 ADV24090.1 - 0.77 9.5 8.1 0.46 10.2 4.5 2.1 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit Tnp_zf-ribbon_2 PF13842.6 ADV24090.1 - 9.4 7.1 12.8 18 6.3 12.8 1.5 1 0 0 1 1 1 0 DDE_Tnp_1-like zinc-ribbon DUF455 PF04305.14 ADV24091.1 - 1.1e-93 313.3 0.0 1.4e-93 313.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF455) Rieske PF00355.26 ADV24091.1 - 1.6e-08 34.4 0.0 3.6e-08 33.2 0.0 1.5 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.6 ADV24091.1 - 1.6e-05 24.7 0.0 3.6e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain PH_10 PF15411.6 ADV24092.1 - 7.3e-35 119.9 0.1 1.4e-34 119.0 0.1 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain RhoGEF PF00621.20 ADV24092.1 - 9.2e-29 101.0 0.0 1.6e-28 100.2 0.0 1.4 1 0 0 1 1 1 1 RhoGEF domain PB1 PF00564.24 ADV24092.1 - 3.3e-09 36.5 0.2 8e-09 35.3 0.2 1.6 1 0 0 1 1 1 1 PB1 domain CDC24 PF06395.11 ADV24092.1 - 0.00022 21.4 0.0 0.014 15.6 0.0 2.7 2 1 0 2 2 2 1 CDC24 Calponin She9_MDM33 PF05546.11 ADV24092.1 - 0.0053 16.6 0.0 0.013 15.3 0.0 1.6 1 0 0 1 1 1 1 She9 / Mdm33 family Imm51 PF15595.6 ADV24092.1 - 0.059 13.3 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 Immunity protein 51 Glyco_hydro_18 PF00704.28 ADV24093.1 - 1.2e-55 189.5 0.2 2.2e-55 188.6 0.2 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Sfi1 PF08457.10 ADV24094.1 - 1.4e-27 96.5 102.9 3.1e-17 62.3 33.3 5.3 1 1 1 4 4 4 4 Sfi1 spindle body protein G-patch PF01585.23 ADV24095.1 - 0.01 15.7 6.4 3.8 7.5 5.8 2.8 2 0 0 2 2 2 0 G-patch domain SNARE_assoc PF09335.11 ADV24096.1 - 2.5e-11 44.1 7.0 2.5e-11 44.1 7.0 2.3 2 0 0 2 2 2 1 SNARE associated Golgi protein SfLAP PF11139.8 ADV24096.1 - 0.00011 21.7 0.0 0.00019 20.9 0.0 1.4 1 0 0 1 1 1 1 Sap, sulfolipid-1-addressing protein DUF3341 PF11821.8 ADV24096.1 - 0.09 12.4 0.0 0.09 12.4 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3341) DUF667 PF05018.13 ADV24097.1 - 1.1e-10 41.6 0.0 6.6e-05 22.7 0.0 2.0 2 0 0 2 2 2 2 Protein of unknown function (DUF667) TOM13 PF08219.11 ADV24098.1 - 8.8e-13 48.0 0.9 1.5e-12 47.3 0.0 1.9 2 0 0 2 2 2 1 Outer membrane protein TOM13 MCM_bind PF09739.9 ADV24098.1 - 0.024 13.1 1.8 0.65 8.4 3.9 1.9 2 0 0 2 2 2 0 Mini-chromosome maintenance replisome factor Borrelia_P83 PF05262.11 ADV24098.1 - 0.18 10.3 14.3 0.23 9.9 14.3 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein Sec62 PF03839.16 ADV24098.1 - 6 6.3 6.2 8.6 5.8 6.2 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 Gar1 PF04410.14 ADV24099.1 - 4.4e-37 127.2 0.0 5.5e-37 126.9 0.0 1.0 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region RNase_H2-Ydr279 PF09468.10 ADV24100.1 - 2.2e-23 83.2 0.0 3.4e-23 82.6 0.0 1.3 1 0 0 1 1 1 1 Ydr279p protein family (RNase H2 complex component) wHTH domain Ydr279_N PF17745.1 ADV24100.1 - 4.4e-07 30.1 0.0 1.2e-06 28.7 0.0 1.8 1 0 0 1 1 1 1 Ydr279p protein triple barrel domain FAD_binding_3 PF01494.19 ADV24101.1 - 1.3e-16 60.8 0.0 1.3e-07 31.3 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain SE PF08491.10 ADV24101.1 - 1.1e-05 24.7 0.0 1.6e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Squalene epoxidase Lycopene_cycl PF05834.12 ADV24101.1 - 0.027 13.5 0.0 0.71 8.9 0.0 2.6 3 0 0 3 3 3 0 Lycopene cyclase protein Myb_CC_LHEQLE PF14379.6 ADV24101.1 - 0.074 12.8 0.2 0.15 11.8 0.2 1.4 1 0 0 1 1 1 0 MYB-CC type transfactor, LHEQLE motif MRP-L20 PF12824.7 ADV24102.1 - 1.9e-07 31.4 11.9 4.6e-07 30.1 10.1 2.2 1 1 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 RRM_1 PF00076.22 ADV24104.1 - 3.1e-21 75.0 0.0 5.8e-21 74.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ADV24104.1 - 5.2e-05 23.3 0.0 0.00011 22.3 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif YL1 PF05764.13 ADV24104.1 - 0.26 11.3 28.3 0.39 10.8 28.3 1.2 1 0 0 1 1 1 0 YL1 nuclear protein tRNA-synt_2 PF00152.20 ADV24105.1 - 2.4e-78 263.4 0.5 4.7e-78 262.4 0.0 1.6 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 ADV24105.1 - 1e-11 44.7 0.1 3e-11 43.2 0.0 1.9 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 ADV24105.1 - 2.9e-10 40.0 0.1 7.1e-06 25.7 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) PCI PF01399.27 ADV24106.1 - 1.8e-08 34.8 0.2 4.2e-08 33.6 0.2 1.6 1 0 0 1 1 1 1 PCI domain CSN7a_helixI PF18392.1 ADV24106.1 - 0.021 14.7 0.0 0.041 13.8 0.0 1.6 1 0 0 1 1 1 0 COP9 signalosome complex subunit 7a helix I domain HSF_DNA-bind PF00447.17 ADV24107.1 - 3.6e-23 82.0 0.1 7.2e-23 81.0 0.1 1.5 1 0 0 1 1 1 1 HSF-type DNA-binding AAA PF00004.29 ADV24108.1 - 5.4e-53 178.9 0.0 1.9e-45 154.5 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ADV24108.1 - 1.2e-08 34.6 5.2 4.9e-06 26.2 0.2 3.0 3 0 0 3 3 3 2 AAA+ lid domain AAA_16 PF13191.6 ADV24108.1 - 3e-08 34.2 0.5 0.0041 17.5 0.1 3.7 2 1 0 3 3 3 2 AAA ATPase domain RuvB_N PF05496.12 ADV24108.1 - 4.8e-05 23.2 0.0 0.0018 18.0 0.0 2.4 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain Vps4_C PF09336.10 ADV24108.1 - 8.9e-05 22.4 0.1 0.005 16.8 0.1 2.6 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain TsaE PF02367.17 ADV24108.1 - 9.1e-05 22.5 0.0 0.062 13.3 0.0 2.5 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_5 PF07728.14 ADV24108.1 - 0.0003 20.8 0.0 0.021 14.8 0.0 2.7 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ADV24108.1 - 0.0006 20.1 0.0 0.0085 16.4 0.1 2.7 2 1 1 3 3 3 1 AAA domain TIP49 PF06068.13 ADV24108.1 - 0.0019 17.5 0.0 0.025 13.8 0.0 2.1 2 0 0 2 2 2 1 TIP49 P-loop domain DUF815 PF05673.13 ADV24108.1 - 0.0037 16.5 0.0 1.1 8.4 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF815) ATPase PF06745.13 ADV24108.1 - 0.0052 16.2 0.0 0.0096 15.3 0.0 1.3 1 0 0 1 1 1 1 KaiC AAA_33 PF13671.6 ADV24108.1 - 0.0056 16.8 0.0 0.66 10.1 0.0 3.7 4 0 0 4 4 4 1 AAA domain RNA_helicase PF00910.22 ADV24108.1 - 0.006 17.0 0.0 0.062 13.7 0.0 2.6 2 0 0 2 2 2 1 RNA helicase IstB_IS21 PF01695.17 ADV24108.1 - 0.0061 16.3 0.0 0.015 15.0 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_18 PF13238.6 ADV24108.1 - 0.0072 16.9 0.1 0.053 14.1 0.0 2.5 3 0 0 3 3 2 1 AAA domain Parvo_NS1 PF01057.17 ADV24108.1 - 0.0086 15.2 0.0 0.016 14.4 0.0 1.3 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 AAA_2 PF07724.14 ADV24108.1 - 0.0095 16.1 0.0 0.024 14.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) Mg_chelatase PF01078.21 ADV24108.1 - 0.013 14.9 0.1 0.045 13.1 0.1 1.9 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_25 PF13481.6 ADV24108.1 - 0.021 14.4 0.0 0.052 13.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 ADV24108.1 - 0.025 14.3 0.0 1.6 8.4 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_7 PF12775.7 ADV24108.1 - 0.04 13.4 0.0 0.16 11.5 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_28 PF13521.6 ADV24108.1 - 0.053 13.8 0.0 0.48 10.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 ADV24108.1 - 0.08 12.2 0.1 10 5.3 0.0 2.6 2 0 0 2 2 2 0 Zeta toxin AAA_24 PF13479.6 ADV24108.1 - 0.081 12.6 0.1 0.16 11.7 0.1 1.4 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 ADV24108.1 - 0.081 12.8 0.3 3.6 7.5 0.1 2.6 2 0 0 2 2 2 0 NACHT domain PhoH PF02562.16 ADV24108.1 - 0.11 11.9 0.0 0.22 11.0 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein AAA_3 PF07726.11 ADV24108.1 - 0.14 12.0 0.0 0.46 10.3 0.0 1.9 2 0 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 ADV24108.1 - 0.16 12.0 0.0 2.9 7.9 0.0 2.5 2 0 0 2 2 2 0 AAA domain WD40 PF00400.32 ADV24109.1 - 0.18 12.7 4.6 18 6.4 0.3 4.0 3 0 0 3 3 3 0 WD domain, G-beta repeat ACPS PF01648.20 ADV24110.1 - 6.3e-26 90.7 0.0 9.1e-26 90.2 0.0 1.2 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily 4PPT_N PF17837.1 ADV24110.1 - 0.0038 17.3 0.0 0.011 15.9 0.0 1.7 1 1 0 1 1 1 1 4'-phosphopantetheinyl transferase N-terminal domain DHHC PF01529.20 ADV24111.1 - 8.2e-12 45.4 1.7 8.2e-12 45.4 1.7 2.2 2 1 0 2 2 2 1 DHHC palmitoyltransferase Pox_A_type_inc PF04508.12 ADV24112.1 - 0.00053 19.7 2.2 0.16 11.9 0.0 3.6 3 0 0 3 3 3 1 Viral A-type inclusion protein repeat Tropomyosin_1 PF12718.7 ADV24112.1 - 0.00091 19.4 12.8 0.00091 19.4 12.8 1.8 1 1 1 2 2 2 1 Tropomyosin like BicD PF09730.9 ADV24112.1 - 0.0082 14.6 11.2 0.0091 14.5 11.2 1.1 1 0 0 1 1 1 1 Microtubule-associated protein Bicaudal-D GAS PF13851.6 ADV24112.1 - 0.04 13.3 11.4 0.05 12.9 11.4 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Ribosomal_L20 PF00453.18 ADV24112.1 - 0.15 12.1 4.0 0.27 11.3 1.0 2.1 1 1 1 2 2 2 0 Ribosomal protein L20 DHR10 PF18595.1 ADV24112.1 - 0.21 11.7 17.1 0.2 11.7 14.3 2.2 2 1 0 2 2 2 0 Designed helical repeat protein 10 domain RAP1 PF07218.11 ADV24112.1 - 0.23 9.7 5.7 0.25 9.6 5.7 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Prefoldin_2 PF01920.20 ADV24112.1 - 0.37 10.8 8.0 1.1 9.2 8.0 2.0 1 1 0 1 1 1 0 Prefoldin subunit DUF572 PF04502.13 ADV24112.1 - 0.64 9.6 10.6 0.69 9.5 10.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) DASH_Spc19 PF08287.11 ADV24112.1 - 1.9 8.4 11.4 2.8 7.8 11.4 1.3 1 1 0 1 1 1 0 Spc19 V_ATPase_I PF01496.19 ADV24112.1 - 2.3 6.1 5.8 2.5 5.9 5.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family APG6_N PF17675.1 ADV24112.1 - 5.9 7.4 22.6 20 5.7 22.6 1.9 1 1 0 1 1 1 0 Apg6 coiled-coil region Med21 PF11221.8 ADV24112.1 - 6.8 6.9 11.3 1.8 8.8 5.6 2.5 1 1 2 3 3 3 0 Subunit 21 of Mediator complex Pkinase PF00069.25 ADV24113.1 - 6.7e-64 215.8 0.0 4e-62 210.0 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ADV24113.1 - 1.1e-25 90.4 0.0 4.8e-25 88.3 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ADV24113.1 - 0.00051 19.4 0.0 0.00087 18.7 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Med17 PF10156.9 ADV24114.1 - 1.2e-74 251.7 0.0 1.5e-74 251.5 0.0 1.1 1 0 0 1 1 1 1 Subunit 17 of Mediator complex SMN PF06003.12 ADV24114.1 - 0.073 12.3 3.9 0.046 13.0 2.3 1.5 2 0 0 2 2 2 0 Survival motor neuron protein (SMN) DUF1258 PF06869.12 ADV24115.1 - 0.18 11.2 0.0 0.31 10.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1258) DUF4645 PF15488.6 ADV24115.1 - 0.76 9.2 4.5 0.73 9.2 0.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4645) DUF4218 PF13960.6 ADV24116.1 - 0.0059 16.2 0.0 0.02 14.5 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4218) Flagellin_N PF00669.20 ADV24117.1 - 0.00034 20.7 0.2 0.00053 20.1 0.2 1.2 1 0 0 1 1 1 1 Bacterial flagellin N-terminal helical region NPV_P10 PF05531.12 ADV24117.1 - 0.25 11.8 3.8 1.2 9.7 0.3 2.4 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein LSM PF01423.22 ADV24118.1 - 4.9e-14 51.8 0.0 6.6e-14 51.4 0.0 1.2 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 ADV24118.1 - 0.024 14.3 0.0 0.035 13.7 0.0 1.3 1 0 0 1 1 1 0 Hfq protein Ten1 PF12658.7 ADV24119.1 - 0.00016 21.6 0.0 0.00033 20.6 0.0 1.5 1 1 0 1 1 1 1 Telomere capping, CST complex subunit Oxysterol_BP PF01237.18 ADV24120.1 - 2.4e-124 415.0 3.1 9.5e-124 413.0 0.0 2.5 2 1 0 2 2 2 1 Oxysterol-binding protein Ank_5 PF13857.6 ADV24120.1 - 9.4e-15 54.5 0.1 3.3e-09 36.8 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ADV24120.1 - 1.7e-09 38.2 0.0 3.6e-06 27.5 0.0 2.4 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) PH PF00169.29 ADV24120.1 - 4.7e-09 36.7 0.0 1e-08 35.6 0.0 1.6 1 0 0 1 1 1 1 PH domain Ank_4 PF13637.6 ADV24120.1 - 7.6e-08 32.8 0.0 0.0002 21.9 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeats (many copies) PH_11 PF15413.6 ADV24120.1 - 7.7e-06 26.3 3.2 1.8e-05 25.1 0.9 2.7 2 1 1 3 3 3 1 Pleckstrin homology domain Ank_3 PF13606.6 ADV24120.1 - 2.4e-05 24.3 0.0 1.1 10.0 0.0 3.9 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 ADV24120.1 - 2.8e-05 24.4 0.1 0.021 15.3 0.0 3.7 3 1 0 3 3 3 1 Ankyrin repeat PH_8 PF15409.6 ADV24120.1 - 0.00046 20.4 0.1 0.001 19.3 0.1 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain DMPK_coil PF08826.10 ADV24120.1 - 1.3 9.1 5.5 3.5 7.8 5.5 1.7 1 0 0 1 1 1 0 DMPK coiled coil domain like Pkinase PF00069.25 ADV24122.1 - 1.7e-62 211.2 0.0 6e-35 120.9 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ADV24122.1 - 9.9e-40 136.4 0.0 8.1e-39 133.5 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ADV24122.1 - 2.6e-06 27.0 0.7 4e-05 23.1 0.0 2.6 2 1 1 3 3 3 1 Kinase-like DUF3552 PF12072.8 ADV24122.1 - 0.0035 16.8 10.9 0.0035 16.8 10.9 1.9 1 1 1 2 2 2 1 Domain of unknown function (DUF3552) APH PF01636.23 ADV24122.1 - 0.2 11.6 1.4 3.3 7.6 0.0 2.6 2 1 1 3 3 3 0 Phosphotransferase enzyme family DASH_Spc19 PF08287.11 ADV24122.1 - 0.3 11.0 8.5 0.55 10.1 8.5 1.3 1 0 0 1 1 1 0 Spc19 Atg14 PF10186.9 ADV24122.1 - 0.49 9.4 10.0 0.98 8.4 10.0 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Exonuc_VII_L PF02601.15 ADV24122.1 - 6.9 6.1 6.5 12 5.3 6.5 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit UPF0242 PF06785.11 ADV24122.1 - 9.4 6.3 12.8 25 4.9 12.8 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus MFS_1 PF07690.16 ADV24123.1 - 2.4e-35 122.1 30.2 6.5e-34 117.4 28.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MWFE PF15879.5 ADV24123.1 - 0.021 15.0 0.0 0.12 12.5 0.0 2.4 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase MWFE subunit Arrestin_C PF02752.22 ADV24124.1 - 3.1e-05 24.4 0.0 0.00017 22.0 0.0 2.1 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 ADV24124.1 - 0.086 12.9 0.0 0.19 11.8 0.0 1.5 1 0 0 1 1 1 0 Arrestin (or S-antigen), N-terminal domain DSHCT PF08148.12 ADV24125.1 - 3.5e-48 163.4 0.1 7.3e-48 162.3 0.1 1.5 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.29 ADV24125.1 - 2.5e-18 66.5 0.1 4.8e-18 65.5 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Ski2_N PF17911.1 ADV24125.1 - 5e-17 62.0 0.0 1.4e-16 60.5 0.0 1.7 1 0 0 1 1 1 1 Ski2 N-terminal region rRNA_proc-arch PF13234.6 ADV24125.1 - 4.8e-11 43.1 2.2 1.3e-05 25.3 0.1 2.3 2 0 0 2 2 2 2 rRNA-processing arch domain ResIII PF04851.15 ADV24125.1 - 1e-06 28.9 0.0 2.1e-06 27.9 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 ADV24125.1 - 1.6e-05 25.2 0.0 5.3e-05 23.5 0.0 2.0 2 1 0 2 2 2 1 Helicase conserved C-terminal domain EpuA PF11772.8 ADV24125.1 - 0.033 13.9 0.3 0.11 12.2 0.0 2.0 2 0 0 2 2 2 0 DNA-directed RNA polymerase subunit beta Zn_clus PF00172.18 ADV24126.1 - 1.7e-06 28.0 10.7 1.7e-06 28.0 10.7 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Phosducin PF02114.16 ADV24127.1 - 9.9e-05 21.4 0.0 0.00012 21.1 0.0 1.2 1 0 0 1 1 1 1 Phosducin Thioredoxin PF00085.20 ADV24127.1 - 0.0044 17.0 0.0 0.007 16.3 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Aldo_ket_red PF00248.21 ADV24129.1 - 2.4e-45 155.0 0.0 3.2e-45 154.6 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family NIF PF03031.18 ADV24131.1 - 6e-22 78.1 0.0 5.1e-19 68.6 0.0 2.3 2 0 0 2 2 2 2 NLI interacting factor-like phosphatase PTCB-BRCT PF12738.7 ADV24131.1 - 1.4e-05 25.0 0.1 3.1e-05 23.8 0.1 1.6 1 0 0 1 1 1 1 twin BRCT domain BRCT PF00533.26 ADV24131.1 - 1.7e-05 25.1 0.0 3.8e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 ADV24131.1 - 0.0045 17.2 0.2 0.011 16.0 0.2 1.6 1 0 0 1 1 1 1 DNA ligase 3 BRCT domain Pkinase PF00069.25 ADV24133.1 - 2.6e-71 240.1 0.0 3.3e-71 239.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV24133.1 - 8.7e-34 117.0 0.0 1.1e-33 116.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 ADV24133.1 - 0.00024 20.2 0.0 0.00059 18.9 0.0 1.5 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 ADV24133.1 - 0.01 15.2 0.0 0.041 13.2 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 ADV24133.1 - 0.078 11.7 0.0 0.13 11.0 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Trypan_PARP PF05887.11 ADV24133.1 - 0.18 11.8 10.0 0.22 11.5 5.1 2.4 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) WD40 PF00400.32 ADV24134.1 - 1.5e-15 57.3 5.4 1.8e-06 28.6 0.2 5.8 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV24134.1 - 0.0096 16.2 0.0 0.92 9.8 0.0 2.8 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain SDA1 PF05285.12 ADV24134.1 - 4.3 6.7 18.7 7.2 5.9 18.7 1.4 1 0 0 1 1 1 0 SDA1 WD40 PF00400.32 ADV24135.1 - 1.3e-20 73.3 20.0 7.4e-06 26.6 0.2 6.5 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV24135.1 - 4.3e-17 62.2 7.3 1.1e-06 28.9 0.2 4.9 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ADV24135.1 - 7.3e-07 28.5 0.0 0.00049 19.2 0.0 3.2 2 1 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ADV24135.1 - 1.5e-06 28.2 0.2 0.051 13.5 0.0 3.1 1 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nbas_N PF15492.6 ADV24135.1 - 0.073 12.4 0.1 7.9 5.7 0.0 2.3 2 0 0 2 2 2 0 Neuroblastoma-amplified sequence, N terminal PQQ_3 PF13570.6 ADV24135.1 - 0.21 12.1 1.7 1.8 9.1 0.0 3.4 4 0 0 4 4 4 0 PQQ-like domain IKI3 PF04762.12 ADV24135.1 - 0.37 8.7 0.8 4 5.3 0.1 2.1 1 1 0 2 2 2 0 IKI3 family DSPc PF00782.20 ADV24136.1 - 0.00015 21.6 0.0 0.00036 20.4 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ADV24136.1 - 0.14 11.7 0.7 0.47 10.0 0.7 1.8 1 1 0 1 1 1 0 Protein-tyrosine phosphatase BCDHK_Adom3 PF10436.9 ADV24138.1 - 1.8e-64 216.5 0.0 2.6e-64 215.9 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 ADV24138.1 - 1.9e-12 47.7 0.0 5.8e-12 46.1 0.0 1.8 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 ADV24138.1 - 0.0079 16.0 0.0 0.013 15.3 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase STAT_alpha PF01017.20 ADV24138.1 - 0.16 11.9 0.0 0.25 11.2 0.0 1.2 1 0 0 1 1 1 0 STAT protein, all-alpha domain GFO_IDH_MocA PF01408.22 ADV24140.1 - 8.3e-16 58.9 0.0 1.6e-15 58.0 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold DDE_1 PF03184.19 ADV24142.1 - 1.5e-20 73.6 0.0 2.2e-20 73.0 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_psq PF05225.16 ADV24142.1 - 0.0003 20.5 0.0 0.0011 18.7 0.0 2.0 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.16 ADV24142.1 - 0.0048 16.9 0.0 0.016 15.2 0.0 2.0 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DDE_3 PF13358.6 ADV24142.1 - 0.013 15.2 0.0 0.051 13.3 0.0 1.9 2 0 0 2 2 2 0 DDE superfamily endonuclease HTH_23 PF13384.6 ADV24142.1 - 0.031 14.1 0.0 0.14 12.0 0.0 2.2 1 0 0 1 1 1 0 Homeodomain-like domain HTH_7 PF02796.15 ADV24142.1 - 0.052 13.6 0.0 0.59 10.2 0.0 2.7 3 0 0 3 3 3 0 Helix-turn-helix domain of resolvase GST_C PF00043.25 ADV24144.1 - 3.4e-14 52.8 0.0 7.1e-14 51.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 ADV24144.1 - 2.9e-11 43.2 0.0 1.4e-10 41.0 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 ADV24144.1 - 6.4e-11 42.3 0.0 1.2e-10 41.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 ADV24144.1 - 7.9e-10 38.9 0.0 2.5e-09 37.4 0.0 1.9 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 ADV24144.1 - 5.1e-08 33.2 0.0 9.9e-08 32.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 ADV24144.1 - 8.6e-07 29.2 0.0 1.6e-06 28.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Glutaredoxin2_C PF04399.13 ADV24144.1 - 0.016 15.0 0.0 0.026 14.4 0.0 1.3 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain Lectin_leg-like PF03388.13 ADV24145.1 - 6.5e-67 225.2 0.5 8.9e-67 224.8 0.5 1.1 1 0 0 1 1 1 1 Legume-like lectin family Bact_lectin PF18483.1 ADV24145.1 - 2.4e-09 37.5 1.5 4.3e-09 36.7 1.5 1.4 1 0 0 1 1 1 1 Bacterial lectin Lectin_legB PF00139.19 ADV24145.1 - 7.1e-06 25.7 0.0 0.0037 16.8 0.0 2.2 2 0 0 2 2 2 2 Legume lectin domain Aldo_ket_red PF00248.21 ADV24146.1 - 3.6e-12 46.1 0.1 2.1e-11 43.5 0.0 1.8 2 0 0 2 2 2 1 Aldo/keto reductase family Ribosomal_S2 PF00318.20 ADV24147.1 - 6.2e-29 100.8 0.3 2.8e-16 59.4 0.1 2.1 1 1 1 2 2 2 2 Ribosomal protein S2 40S_SA_C PF16122.5 ADV24147.1 - 1.5e-08 35.9 14.4 2.5e-08 35.1 14.4 1.4 1 0 0 1 1 1 1 40S ribosomal protein SA C-terminus CNH PF00780.22 ADV24149.1 - 9.9e-83 277.9 0.0 1.6e-82 277.2 0.0 1.3 1 0 0 1 1 1 1 CNH domain PH_5 PF15405.6 ADV24149.1 - 3.1e-43 147.1 0.0 6.1e-43 146.2 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain RhoGEF PF00621.20 ADV24149.1 - 2.2e-37 129.1 0.0 3.3e-37 128.5 0.0 1.3 1 0 0 1 1 1 1 RhoGEF domain DEP PF00610.21 ADV24149.1 - 6.1e-14 51.8 0.0 1.4e-13 50.7 0.0 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PH_13 PF16652.5 ADV24149.1 - 2.8e-05 24.0 0.1 0.00012 21.9 0.1 2.3 1 1 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 ADV24149.1 - 0.014 15.9 0.0 7.4 7.1 0.0 3.5 3 1 0 3 3 3 0 PH domain zf-CCCH PF00642.24 ADV24152.1 - 2e-09 37.1 2.6 3.8e-09 36.2 2.6 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4_3 PF13920.6 ADV24152.1 - 2.5e-08 33.6 6.3 4.5e-08 32.8 6.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ADV24152.1 - 1.3e-07 31.5 8.0 2.5e-07 30.6 8.0 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 ADV24152.1 - 1.8e-06 27.8 9.8 3.1e-06 27.1 9.8 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 ADV24152.1 - 1.4e-05 25.3 7.8 2.5e-05 24.5 7.8 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 ADV24152.1 - 1.4e-05 24.8 10.2 2.5e-05 24.1 10.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ADV24152.1 - 1.5e-05 24.7 10.1 2.7e-05 23.9 10.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf_CCCH_4 PF18345.1 ADV24152.1 - 1.7e-05 24.7 4.5 3.3e-05 23.8 4.5 1.5 1 0 0 1 1 1 1 Zinc finger domain zf-C3HC4_4 PF15227.6 ADV24152.1 - 3.2e-05 24.0 8.6 7.1e-05 22.9 8.6 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-CCCH_4 PF18044.1 ADV24152.1 - 0.00016 21.4 2.8 0.00029 20.5 2.8 1.5 1 0 0 1 1 1 1 CCCH-type zinc finger zf-RING_10 PF16685.5 ADV24152.1 - 0.00031 20.8 4.2 0.00031 20.8 4.2 1.6 2 0 0 2 2 1 1 zinc RING finger of MSL2 Prok-RING_4 PF14447.6 ADV24152.1 - 0.019 14.8 6.7 0.033 14.0 6.7 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Cytochrom_C552 PF02335.15 ADV24152.1 - 0.021 13.8 1.6 0.028 13.4 1.6 1.1 1 0 0 1 1 1 0 Cytochrome c552 zf-Nse PF11789.8 ADV24152.1 - 0.09 12.6 3.5 0.18 11.7 3.5 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zinc-ribbons_6 PF07191.12 ADV24152.1 - 0.14 12.1 4.5 0.32 11.0 4.5 1.6 1 0 0 1 1 1 0 zinc-ribbons zf-P11 PF03854.14 ADV24152.1 - 0.17 11.6 2.8 0.37 10.5 2.8 1.5 1 0 0 1 1 1 0 P-11 zinc finger zf-rbx1 PF12678.7 ADV24152.1 - 0.24 11.7 6.9 0.72 10.2 6.9 1.8 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_6 PF14835.6 ADV24152.1 - 0.91 9.4 3.6 1.7 8.6 3.6 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein RNA_POL_M_15KD PF02150.16 ADV24153.1 - 0.017 15.0 2.2 3.9 7.4 0.8 2.6 1 1 1 2 2 2 0 RNA polymerases M/15 Kd subunit zf_UBZ PF18439.1 ADV24153.1 - 0.065 12.8 3.8 1.1 8.9 0.1 2.5 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-ribbon_3 PF13248.6 ADV24153.1 - 0.11 11.9 1.1 0.22 11.0 0.1 2.0 2 0 0 2 2 2 0 zinc-ribbon domain Orf78 PF06024.12 ADV24153.1 - 1.5 9.1 0.0 1.5 9.1 0.0 3.1 2 1 0 2 2 2 0 Orf78 (ac78) CoxIIa PF08113.11 ADV24153.1 - 1.6 8.6 4.1 2.9 7.8 4.1 1.3 1 0 0 1 1 1 0 Cytochrome c oxidase subunit IIa family Anoctamin PF04547.12 ADV24153.1 - 2.6 6.8 4.7 3.9 6.2 4.7 1.4 1 1 0 1 1 1 0 Calcium-activated chloride channel LRRC37AB_C PF14914.6 ADV24153.1 - 5 7.0 0.0 5 7.0 0.0 3.2 2 1 1 4 4 4 0 LRRC37A/B like protein 1 C-terminal domain Torus PF16131.5 ADV24154.1 - 1e-39 135.6 1.8 1e-39 135.6 1.8 2.2 3 0 0 3 3 3 1 Torus domain RRM_1 PF00076.22 ADV24154.1 - 7.1e-07 29.0 0.0 1.5e-06 27.9 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 ADV24154.1 - 0.0049 16.8 0.0 0.011 15.7 0.0 1.6 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif BUD22 PF09073.10 ADV24154.1 - 0.026 13.9 5.8 0.045 13.1 5.8 1.3 1 0 0 1 1 1 0 BUD22 PHM7_cyt PF14703.6 ADV24154.1 - 0.18 12.0 1.8 12 6.0 0.2 2.5 2 1 1 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter zf-CCCH_4 PF18044.1 ADV24154.1 - 3.2 7.7 11.1 5.5 6.9 11.1 1.4 1 0 0 1 1 1 0 CCCH-type zinc finger RCC1 PF00415.18 ADV24155.1 - 1.2e-16 61.1 9.2 0.02 15.5 0.0 7.5 7 1 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ADV24155.1 - 3.1e-08 33.2 0.7 3.1e-08 33.2 0.7 6.6 7 0 0 7 7 7 1 Regulator of chromosome condensation (RCC1) repeat IF-2B PF01008.17 ADV24157.1 - 6.1e-61 206.1 0.0 7.2e-61 205.9 0.0 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family Zn_Tnp_IS1595 PF12760.7 ADV24158.1 - 0.043 13.8 5.0 0.078 13.0 5.0 1.4 1 0 0 1 1 1 0 Transposase zinc-ribbon domain zinc-ribbons_6 PF07191.12 ADV24158.1 - 0.074 13.0 1.9 0.12 12.4 1.9 1.3 1 0 0 1 1 1 0 zinc-ribbons DAG1 PF05454.11 ADV24158.1 - 0.11 11.9 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) NMDAR2_C PF10565.9 ADV24158.1 - 0.16 10.8 2.3 0.2 10.5 2.3 1.1 1 0 0 1 1 1 0 N-methyl D-aspartate receptor 2B3 C-terminus FeoB_associated PF12669.7 ADV24158.1 - 0.24 11.8 2.8 0.58 10.6 2.8 1.7 1 1 0 1 1 1 0 FeoB-associated Cys-rich membrane protein DUF2730 PF10805.8 ADV24158.1 - 0.27 11.4 1.2 0.3 11.2 0.3 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) FYVE PF01363.21 ADV24158.1 - 0.66 10.2 6.0 3.2 8.0 6.0 2.0 1 1 0 1 1 1 0 FYVE zinc finger RCR PF12273.8 ADV24158.1 - 0.76 10.4 2.3 1.3 9.7 2.3 1.3 1 0 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red Peptidase_M20 PF01546.28 ADV24159.1 - 6.3e-34 117.5 0.0 8.7e-34 117.0 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 ADV24159.1 - 2.9e-11 43.3 0.0 5.6e-11 42.3 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 ADV24159.1 - 0.17 11.5 0.0 0.42 10.3 0.0 1.7 1 1 0 1 1 1 0 Peptidase family M28 F-box_4 PF15966.5 ADV24159.1 - 0.18 11.7 0.0 0.29 11.0 0.0 1.3 1 0 0 1 1 1 0 F-box SPO22 PF08631.10 ADV24160.1 - 2.1e-23 83.2 14.8 1.9e-19 70.3 3.5 3.3 3 1 0 4 4 4 2 Meiosis protein SPO22/ZIP4 like Nup84_Nup100 PF04121.13 ADV24161.1 - 6.1e-111 371.8 0.0 7.8e-111 371.4 0.0 1.0 1 0 0 1 1 1 1 Nuclear pore protein 84 / 107 DEAD PF00270.29 ADV24162.1 - 1.8e-48 164.6 0.0 2.6e-48 164.1 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ADV24162.1 - 3.6e-31 107.8 0.0 1.4e-30 105.8 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ADV24162.1 - 2.8e-05 24.2 0.0 4.9e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 ADV24162.1 - 0.0063 16.3 0.0 0.013 15.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain PAC2 PF09754.9 ADV24162.1 - 0.099 12.6 0.0 0.17 11.9 0.0 1.4 1 0 0 1 1 1 0 PAC2 family Vezatin PF12632.7 ADV24163.1 - 0.15 11.5 0.3 4.7 6.5 0.3 2.5 1 1 0 1 1 1 0 Mysoin-binding motif of peroxisomes Abhydrolase_6 PF12697.7 ADV24164.1 - 6.1e-24 85.9 0.1 1e-23 85.1 0.1 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ADV24164.1 - 4.8e-10 39.1 0.0 6.9e-10 38.6 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ADV24164.1 - 7.1e-07 29.1 0.0 4.7e-06 26.4 0.0 1.9 2 0 0 2 2 2 1 alpha/beta hydrolase fold Thioesterase PF00975.20 ADV24164.1 - 0.0013 18.9 0.0 0.0021 18.2 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain Chlorophyllase2 PF12740.7 ADV24164.1 - 0.15 10.9 0.0 0.26 10.2 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase enzyme GHMP_kinases_N PF00288.26 ADV24166.1 - 3.9e-08 33.4 0.1 1.1e-07 32.0 0.1 1.8 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 ADV24166.1 - 0.0015 18.9 0.0 0.0034 17.7 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal WD40 PF00400.32 ADV24167.1 - 2.2e-28 97.9 21.3 2e-05 25.2 0.1 8.6 8 1 0 8 8 8 4 WD domain, G-beta repeat Hira PF07569.11 ADV24167.1 - 9.2e-26 90.9 0.2 2e-24 86.5 0.2 2.3 1 1 0 1 1 1 1 TUP1-like enhancer of split ANAPC4_WD40 PF12894.7 ADV24167.1 - 8.5e-16 58.0 1.8 0.32 11.3 0.0 7.7 4 3 2 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ADV24167.1 - 0.0011 18.0 1.2 1.2 8.0 0.0 3.8 4 1 1 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Mcl1_mid PF12341.8 ADV24167.1 - 0.0036 16.7 0.0 0.0063 15.9 0.0 1.3 1 0 0 1 1 1 1 Minichromosome loss protein, Mcl1, middle region Nbas_N PF15492.6 ADV24167.1 - 0.0072 15.7 0.2 0.85 8.9 0.0 3.0 3 0 0 3 3 3 1 Neuroblastoma-amplified sequence, N terminal Nup160 PF11715.8 ADV24167.1 - 0.039 12.6 1.2 2.1 6.9 0.2 3.2 3 1 1 4 4 4 0 Nucleoporin Nup120/160 PD40 PF07676.12 ADV24167.1 - 0.43 10.6 2.1 1e+02 3.0 0.0 3.8 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat GldM_N PF12081.8 ADV24168.1 - 0.034 14.3 0.1 0.22 11.6 0.0 2.0 2 0 0 2 2 2 0 GldM N-terminal domain SlyX PF04102.12 ADV24168.1 - 0.054 14.1 0.9 0.23 12.1 0.6 2.1 2 0 0 2 2 2 0 SlyX THP2 PF09432.10 ADV24168.1 - 0.088 12.9 2.0 2.5 8.2 0.1 3.0 2 1 0 3 3 3 0 Tho complex subunit THP2 PilO PF04350.13 ADV24168.1 - 0.13 12.4 0.1 0.24 11.6 0.1 1.4 1 0 0 1 1 1 0 Pilus assembly protein, PilO COG5 PF10392.9 ADV24168.1 - 0.36 11.0 4.1 0.37 11.0 0.9 2.2 2 1 1 3 3 3 0 Golgi transport complex subunit 5 IBR PF01485.21 ADV24169.1 - 1.7e-18 66.6 45.0 2.1e-11 43.9 3.4 4.3 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.25 ADV24169.1 - 1.3e-05 24.9 1.8 1.3e-05 24.9 1.8 4.1 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ADV24169.1 - 4.4e-05 23.7 2.2 4.4e-05 23.7 2.2 4.0 4 0 0 4 4 4 1 Ring finger domain zf-RING_UBOX PF13445.6 ADV24169.1 - 5.8e-05 23.0 2.2 5.8e-05 23.0 2.2 3.3 3 1 0 3 3 3 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 ADV24169.1 - 0.00017 21.3 1.4 0.00017 21.3 1.4 4.4 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ADV24169.1 - 0.00038 20.4 4.7 0.00038 20.4 4.7 3.8 3 1 1 4 4 4 1 zinc-RING finger domain FHA PF00498.26 ADV24172.1 - 1.6e-17 63.6 0.0 3.5e-17 62.5 0.0 1.6 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 ADV24172.1 - 0.00013 22.2 0.0 0.0076 16.6 0.0 2.5 1 1 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Linker_histone PF00538.19 ADV24173.1 - 6.7e-21 74.4 0.1 6.7e-21 74.4 0.1 3.1 2 1 1 3 3 3 1 linker histone H1 and H5 family FAM220 PF15487.6 ADV24173.1 - 2.7 7.5 7.2 5.3 6.6 7.0 1.5 1 1 0 1 1 1 0 FAM220 family HC2 PF07382.11 ADV24173.1 - 5.6 7.0 85.2 14 5.7 45.3 2.3 1 1 1 2 2 2 0 Histone H1-like nucleoprotein HC2 WD40 PF00400.32 ADV24174.1 - 0.00011 22.9 2.9 1.7 9.6 0.0 5.0 4 0 0 4 4 4 2 WD domain, G-beta repeat Phage_T4_gp36 PF03903.13 ADV24175.1 - 0.028 14.4 0.6 3.5 7.6 0.0 2.2 1 1 1 2 2 2 0 Phage T4 tail fibre Rot1 PF10681.9 ADV24176.1 - 7.9e-70 234.6 0.2 8.9e-70 234.4 0.2 1.0 1 0 0 1 1 1 1 Chaperone for protein-folding within the ER, fungal Skp1 PF01466.19 ADV24179.1 - 0.13 12.4 0.0 0.4 10.8 0.0 1.8 1 0 0 1 1 1 0 Skp1 family, dimerisation domain Ribosomal_L27A PF00828.19 ADV24180.1 - 4.4e-30 105.0 0.0 6.1e-30 104.5 0.0 1.2 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Fungal_trans PF04082.18 ADV24181.1 - 2.9e-13 49.5 0.1 4.8e-13 48.8 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 ADV24181.1 - 6.4e-08 32.6 9.3 0.0027 18.1 2.3 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ADV24181.1 - 0.0004 21.0 16.8 0.0047 17.7 0.4 3.4 4 0 0 4 4 4 2 C2H2-type zinc finger zf-Di19 PF05605.12 ADV24181.1 - 0.19 12.1 1.4 0.46 10.8 1.4 1.6 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_2 PF13465.6 ADV24181.1 - 0.27 11.8 6.3 0.058 13.8 1.4 2.4 2 0 0 2 2 2 0 Zinc-finger double domain FOXP-CC PF16159.5 ADV24181.1 - 2.2 9.0 6.3 0.13 12.9 0.7 1.9 2 0 0 2 2 2 0 FOXP coiled-coil domain zf-C2HC_2 PF13913.6 ADV24181.1 - 7.3 6.6 7.7 0.49 10.4 1.4 2.3 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-C2H2_6 PF13912.6 ADV24181.1 - 7.6 6.7 7.7 0.61 10.1 0.1 2.8 3 0 0 3 3 3 0 C2H2-type zinc finger DUF4992 PF16383.5 ADV24182.1 - 0.2 11.2 0.0 0.25 10.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function WSC PF01822.19 ADV24183.1 - 8.1e-34 115.7 46.2 1.4e-17 63.6 12.8 4.7 4 0 0 4 4 4 3 WSC domain NPCBM_assoc PF10633.9 ADV24183.1 - 1.9 8.8 8.9 2.7 8.3 0.7 3.7 3 2 0 3 3 3 0 NPCBM-associated, NEW3 domain of alpha-galactosidase DUF908 PF06012.12 ADV24184.1 - 7.7e-70 236.1 2.4 7.7e-70 236.1 2.4 2.2 2 0 0 2 2 2 1 Domain of Unknown Function (DUF908) DUF913 PF06025.12 ADV24184.1 - 2.5e-67 227.5 0.4 2.5e-67 227.5 0.4 5.1 5 1 0 5 5 5 1 Domain of Unknown Function (DUF913) UBM PF14377.6 ADV24184.1 - 2.7e-17 61.6 9.0 4.3e-08 32.3 1.0 3.3 2 0 0 2 2 2 2 Ubiquitin binding region UBA PF00627.31 ADV24184.1 - 2.6e-08 33.6 0.0 8.1e-08 32.0 0.0 2.0 1 0 0 1 1 1 1 UBA/TS-N domain zf-C2H2 PF00096.26 ADV24185.1 - 2e-06 28.0 4.6 0.00052 20.3 0.8 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ADV24185.1 - 6e-06 26.7 1.4 0.022 15.6 0.2 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 ADV24185.1 - 0.002 18.1 2.4 0.0034 17.3 1.1 2.0 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2HC_2 PF13913.6 ADV24185.1 - 0.078 12.9 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 zinc-finger of a C2HC-type FOXP-CC PF16159.5 ADV24186.1 - 5.7e-06 26.9 5.1 0.007 17.0 2.5 2.5 2 0 0 2 2 2 2 FOXP coiled-coil domain zf-H2C2_2 PF13465.6 ADV24186.1 - 8.7e-05 22.8 0.1 8.7e-05 22.8 0.1 3.5 4 0 0 4 4 4 1 Zinc-finger double domain zf-C2H2 PF00096.26 ADV24186.1 - 0.00036 20.8 0.2 0.00036 20.8 0.2 3.3 3 1 0 3 3 3 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ADV24186.1 - 0.00062 20.4 7.7 0.034 15.0 0.1 3.2 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 ADV24186.1 - 0.0015 18.4 0.8 0.0042 17.0 0.1 2.1 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_8 PF15909.5 ADV24186.1 - 0.011 16.0 1.4 0.25 11.7 0.2 2.4 1 1 0 2 2 2 0 C2H2-type zinc ribbon zf-C2H2_aberr PF17017.5 ADV24186.1 - 0.29 11.3 2.9 4.1 7.5 0.1 2.2 1 1 1 2 2 2 0 Aberrant zinc-finger Aldedh PF00171.22 ADV24187.1 - 1.5e-124 416.0 0.4 2e-124 415.6 0.4 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 ADV24187.1 - 0.058 12.4 0.0 0.13 11.3 0.0 1.5 2 0 0 2 2 2 0 Acyl-CoA reductase (LuxC) Mgm101p PF06420.12 ADV24188.1 - 5.8e-86 286.3 0.0 7.3e-86 286.0 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial genome maintenance MGM101 YEATS PF03366.16 ADV24189.1 - 1.4e-34 117.9 0.0 2.2e-34 117.3 0.0 1.3 1 0 0 1 1 1 1 YEATS family CASP_C PF08172.12 ADV24189.1 - 0.013 14.9 0.0 0.02 14.3 0.0 1.2 1 0 0 1 1 1 0 CASP C terminal VHS PF00790.19 ADV24190.1 - 4.2e-19 68.8 0.0 1.3e-18 67.2 0.0 1.8 2 0 0 2 2 2 1 VHS domain GAT PF03127.14 ADV24190.1 - 6.7e-06 26.3 0.1 2.4e-05 24.6 0.1 2.0 1 1 0 1 1 1 1 GAT domain Fungal_trans PF04082.18 ADV24192.1 - 1.4e-17 63.7 0.0 2.2e-17 63.0 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Caskin-Pro-rich PF16907.5 ADV24192.1 - 0.027 15.0 4.3 0.027 15.0 4.3 2.1 2 0 0 2 2 2 0 Proline rich region of Caskin proteins RCDG1 PF15725.5 ADV24192.1 - 1.5 9.3 6.7 2 8.9 3.9 2.4 1 1 1 2 2 2 0 Renal cancer differentiation gene 1 protein DUF5082 PF16888.5 ADV24195.1 - 0.025 14.9 3.5 1.9 8.8 0.2 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF5082) DHHC PF01529.20 ADV24196.1 - 2.5e-37 128.0 2.9 2.5e-37 128.0 2.9 2.1 2 0 0 2 2 2 1 DHHC palmitoyltransferase PMT PF02366.18 ADV24196.1 - 0.0088 15.7 0.7 0.018 14.7 0.7 1.5 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase SMC_N PF02463.19 ADV24197.1 - 1.2e-22 80.5 0.0 2e-22 79.7 0.0 1.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 ADV24197.1 - 2.4e-17 64.1 0.0 2.4e-17 64.1 0.0 4.7 3 2 1 5 5 5 1 AAA domain AAA_29 PF13555.6 ADV24197.1 - 0.00023 20.8 0.0 0.00068 19.3 0.0 1.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_13 PF13166.6 ADV24197.1 - 0.00056 18.7 48.2 0.075 11.7 14.6 4.4 3 1 1 4 4 4 3 AAA domain AAA PF00004.29 ADV24197.1 - 0.00095 19.6 0.6 0.25 11.8 0.0 4.0 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_21 PF13304.6 ADV24197.1 - 0.0067 16.3 0.0 0.0067 16.3 0.0 3.4 4 0 0 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system TMF_TATA_bd PF12325.8 ADV24197.1 - 0.0075 16.5 7.3 0.0075 16.5 7.3 7.2 4 2 3 7 7 7 1 TATA element modulatory factor 1 TATA binding AAA_27 PF13514.6 ADV24197.1 - 0.03 13.9 0.0 0.03 13.9 0.0 3.6 3 0 0 3 3 3 0 AAA domain ABC_tran PF00005.27 ADV24197.1 - 0.12 12.8 0.0 0.12 12.8 0.0 4.3 4 1 0 4 4 3 0 ABC transporter NPV_P10 PF05531.12 ADV24197.1 - 0.13 12.7 24.3 1.2 9.6 0.1 6.3 6 1 1 7 7 7 0 Nucleopolyhedrovirus P10 protein Baculo_PEP_C PF04513.12 ADV24197.1 - 0.26 11.3 12.1 0.52 10.4 0.3 4.9 6 0 0 6 6 6 0 Baculovirus polyhedron envelope protein, PEP, C terminus Sec34 PF04136.15 ADV24197.1 - 0.39 10.6 20.8 0.21 11.4 2.1 5.0 4 1 1 5 5 5 0 Sec34-like family SAGA-Tad1 PF12767.7 ADV24199.1 - 2.5e-37 128.9 1.3 4.1e-37 128.2 0.0 2.0 3 0 0 3 3 3 1 Transcriptional regulator of RNA polII, SAGA, subunit AlaDh_PNT_N PF05222.15 ADV24200.1 - 2.1e-27 96.1 0.0 3.4e-27 95.4 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain AlaDh_PNT_C PF01262.21 ADV24200.1 - 2.5e-05 23.7 0.0 8.8e-05 21.9 0.0 1.9 1 1 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain DUF3432 PF11914.8 ADV24201.1 - 1.1 9.5 13.7 3.7 7.9 13.7 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF3432) Gly-rich_Ago1 PF12764.7 ADV24202.1 - 0.0012 19.6 2.0 0.0022 18.8 2.0 1.5 1 1 0 1 1 1 1 Glycine-rich region of argonaut CBP_BcsO PF17037.5 ADV24202.1 - 0.14 12.3 4.8 0.16 12.1 4.8 1.2 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsO Pkinase PF00069.25 ADV24203.1 - 4.4e-69 232.8 0.0 7e-69 232.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV24203.1 - 1.3e-50 172.1 0.0 2.7e-50 171.1 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ADV24203.1 - 0.0049 15.7 0.0 0.013 14.3 0.0 1.6 1 0 0 1 1 1 1 Fungal protein kinase Arm PF00514.23 ADV24203.1 - 0.0058 16.6 0.8 4.8 7.4 0.0 5.1 5 0 0 5 5 5 1 Armadillo/beta-catenin-like repeat FTA2 PF13095.6 ADV24203.1 - 0.023 14.3 0.0 0.046 13.3 0.0 1.5 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Kinase-like PF14531.6 ADV24203.1 - 0.028 13.7 0.0 0.076 12.3 0.0 1.6 2 0 0 2 2 2 0 Kinase-like CTNNBL PF08216.11 ADV24203.1 - 0.08 13.1 0.1 0.35 11.0 0.1 2.1 1 0 0 1 1 1 0 Catenin-beta-like, Arm-motif containing nuclear Kdo PF06293.14 ADV24203.1 - 0.11 11.8 0.0 0.24 10.8 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family AAA PF00004.29 ADV24204.1 - 6.8e-56 188.3 0.0 5.7e-44 149.7 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) PEX-1N PF09262.11 ADV24204.1 - 7.7e-26 90.3 0.2 1.7e-25 89.2 0.2 1.6 1 0 0 1 1 1 1 Peroxisome biogenesis factor 1, N-terminal AAA_lid_3 PF17862.1 ADV24204.1 - 1.9e-13 50.0 0.2 1.9e-08 34.0 0.1 2.8 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 ADV24204.1 - 3e-11 44.0 0.9 0.021 15.2 0.0 4.5 2 2 2 4 4 4 2 AAA ATPase domain RuvB_N PF05496.12 ADV24204.1 - 2.5e-07 30.6 0.0 0.0028 17.4 0.0 2.7 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 ADV24204.1 - 1.8e-06 28.0 0.0 0.023 14.7 0.0 2.6 2 0 0 2 2 2 2 AAA domain NACHT PF05729.12 ADV24204.1 - 2.1e-06 27.8 4.4 0.023 14.6 1.2 4.3 3 1 0 3 3 3 1 NACHT domain AAA_5 PF07728.14 ADV24204.1 - 2.4e-06 27.6 0.0 0.036 14.0 0.0 3.0 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ADV24204.1 - 3.1e-06 27.5 1.5 1.3 9.3 0.2 4.5 2 2 1 3 3 3 2 AAA domain RNA_helicase PF00910.22 ADV24204.1 - 1.8e-05 25.1 0.0 0.14 12.6 0.0 2.7 2 0 0 2 2 2 2 RNA helicase IstB_IS21 PF01695.17 ADV24204.1 - 2.3e-05 24.2 0.0 0.059 13.1 0.0 2.3 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_18 PF13238.6 ADV24204.1 - 5.6e-05 23.7 0.0 0.13 12.8 0.0 2.7 2 0 0 2 2 2 2 AAA domain TsaE PF02367.17 ADV24204.1 - 0.00015 21.7 0.0 0.21 11.6 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE Rad17 PF03215.15 ADV24204.1 - 0.00036 20.5 0.0 0.15 11.9 0.0 2.6 2 0 0 2 2 2 1 Rad17 P-loop domain Mg_chelatase PF01078.21 ADV24204.1 - 0.0014 18.0 0.1 0.68 9.3 0.0 2.6 3 0 0 3 3 2 1 Magnesium chelatase, subunit ChlI ABC_tran PF00005.27 ADV24204.1 - 0.0014 19.1 0.0 0.44 11.0 0.0 2.9 2 0 0 2 2 2 1 ABC transporter DUF815 PF05673.13 ADV24204.1 - 0.0016 17.7 0.0 0.067 12.3 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_33 PF13671.6 ADV24204.1 - 0.0017 18.5 0.0 0.046 13.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain ATPase_2 PF01637.18 ADV24204.1 - 0.002 18.1 0.0 0.16 11.8 0.0 2.4 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea AAA_28 PF13521.6 ADV24204.1 - 0.0026 18.0 0.0 2.2 8.5 0.0 2.7 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 ADV24204.1 - 0.0027 17.0 0.0 2.6 7.3 0.0 2.4 2 0 0 2 2 2 2 Zeta toxin AAA_7 PF12775.7 ADV24204.1 - 0.0032 17.0 0.0 0.58 9.7 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region Bac_DnaA PF00308.18 ADV24204.1 - 0.0039 17.1 0.0 0.97 9.2 0.0 2.6 3 0 0 3 3 2 1 Bacterial dnaA protein AAA_2 PF07724.14 ADV24204.1 - 0.0045 17.1 0.0 0.11 12.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) Sigma54_activ_2 PF14532.6 ADV24204.1 - 0.0053 16.9 0.0 1.7 8.8 0.0 2.9 2 0 0 2 2 2 1 Sigma-54 interaction domain TIP49 PF06068.13 ADV24204.1 - 0.0074 15.5 0.1 0.094 11.9 0.0 2.1 2 0 0 2 2 2 1 TIP49 P-loop domain Viral_helicase1 PF01443.18 ADV24204.1 - 0.008 15.9 0.0 0.61 9.8 0.0 2.4 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA_25 PF13481.6 ADV24204.1 - 0.012 15.2 2.8 1.4 8.5 0.1 3.6 2 2 0 3 3 3 0 AAA domain AAA_24 PF13479.6 ADV24204.1 - 0.019 14.7 0.1 8.7 6.0 0.0 2.8 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.9 ADV24204.1 - 0.026 14.3 0.1 0.4 10.4 0.0 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Sigma54_activat PF00158.26 ADV24204.1 - 0.033 13.9 0.0 5.5 6.7 0.0 2.6 2 1 0 2 2 2 0 Sigma-54 interaction domain DAP3 PF10236.9 ADV24204.1 - 0.04 13.1 0.4 17 4.5 0.0 3.2 2 1 1 3 3 3 0 Mitochondrial ribosomal death-associated protein 3 NB-ARC PF00931.22 ADV24204.1 - 0.042 13.0 0.0 3.3 6.8 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain AAA_19 PF13245.6 ADV24204.1 - 0.056 13.8 0.1 1.6 9.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain SKI PF01202.22 ADV24204.1 - 0.068 13.3 0.1 3.5 7.7 0.0 2.5 2 0 0 2 2 2 0 Shikimate kinase AAA_17 PF13207.6 ADV24204.1 - 0.068 13.6 1.0 0.35 11.3 0.1 2.7 3 0 0 3 3 2 0 AAA domain Cytidylate_kin2 PF13189.6 ADV24204.1 - 0.11 12.7 0.0 0.32 11.1 0.0 1.8 1 0 0 1 1 1 0 Cytidylate kinase-like family Vps4_C PF09336.10 ADV24204.1 - 0.11 12.6 0.0 0.36 10.9 0.0 1.9 1 0 0 1 1 1 0 Vps4 C terminal oligomerisation domain AAA_PrkA PF08298.11 ADV24204.1 - 0.14 11.0 0.0 0.28 10.1 0.0 1.4 1 0 0 1 1 1 0 PrkA AAA domain Gtr1_RagA PF04670.12 ADV24204.1 - 0.22 10.9 0.0 0.45 9.8 0.0 1.5 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region SUV3_C PF12513.8 ADV24205.1 - 3.8e-17 62.0 0.5 1.2e-16 60.3 0.2 2.1 2 0 0 2 2 2 1 Mitochondrial degradasome RNA helicase subunit C terminal Suv3_C_1 PF18147.1 ADV24205.1 - 7.7e-14 51.3 0.0 1.8e-13 50.1 0.0 1.7 1 0 0 1 1 1 1 Suv3 C-terminal domain 1 Helicase_C PF00271.31 ADV24205.1 - 1.8e-12 47.6 0.0 3.6e-12 46.6 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain PH PF00169.29 ADV24206.1 - 5.2e-35 120.1 4.7 1.3e-21 77.0 0.4 3.4 2 1 0 2 2 2 2 PH domain PH_3 PF14593.6 ADV24206.1 - 1e-16 60.9 1.2 5.8e-09 36.0 0.8 3.2 3 0 0 3 3 3 3 PH domain PH_11 PF15413.6 ADV24206.1 - 6.4e-14 52.3 14.6 2.7e-06 27.8 7.3 4.2 2 2 0 2 2 2 2 Pleckstrin homology domain PH_8 PF15409.6 ADV24206.1 - 8.7e-13 48.4 1.8 1.4e-06 28.5 0.6 3.2 3 0 0 3 3 3 2 Pleckstrin homology domain PH_9 PF15410.6 ADV24206.1 - 2.1e-05 24.9 3.3 0.001 19.4 1.0 3.9 3 1 0 3 3 3 1 Pleckstrin homology domain PH_13 PF16652.5 ADV24206.1 - 4.1e-05 23.4 0.8 0.0082 16.0 0.8 2.6 2 0 0 2 2 2 1 Pleckstrin homology domain Myosin_TH1 PF06017.13 ADV24206.1 - 0.00031 20.5 0.1 0.18 11.5 0.0 2.2 2 0 0 2 2 2 2 Unconventional myosin tail, actin- and lipid-binding PH_6 PF15406.6 ADV24206.1 - 0.001 19.3 0.2 0.15 12.3 0.0 3.2 3 0 0 3 3 3 1 Pleckstrin homology domain PH_4 PF15404.6 ADV24206.1 - 0.0027 17.5 1.2 0.16 11.8 0.1 3.0 2 1 1 3 3 3 1 Pleckstrin homology domain SKN1 PF03935.15 ADV24207.1 - 3.1e-212 705.4 7.8 3.6e-212 705.2 7.8 1.0 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) DUF4490 PF14892.6 ADV24207.1 - 0.096 12.8 0.2 0.19 11.8 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4490) SKN1 PF03935.15 ADV24208.1 - 1.6e-208 693.2 2.8 1.8e-208 693.0 2.8 1.0 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) AIF_C PF14721.6 ADV24208.1 - 0.059 13.7 0.0 0.12 12.7 0.0 1.4 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Aa_trans PF01490.18 ADV24209.1 - 7.4e-87 291.7 31.9 8.8e-87 291.4 31.9 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein DUF2314 PF10077.9 ADV24209.1 - 0.2 11.7 0.0 0.36 10.9 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2314) DUF3760 PF12586.8 ADV24210.1 - 9.2e-12 45.0 4.0 1.8e-11 44.0 4.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3760) YL1 PF05764.13 ADV24211.1 - 1e-38 133.9 24.6 1e-38 133.9 24.6 3.1 3 0 0 3 3 3 1 YL1 nuclear protein YL1_C PF08265.11 ADV24211.1 - 5.7e-07 29.2 0.3 9.8e-07 28.4 0.3 1.4 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain AP3D1 PF06375.11 ADV24211.1 - 0.0059 16.9 0.7 0.0059 16.9 0.7 3.9 3 1 2 5 5 5 1 AP-3 complex subunit delta-1 DUF775 PF05603.12 ADV24211.1 - 0.52 9.8 1.5 1.5 8.3 1.5 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF775) WD40 PF00400.32 ADV24212.1 - 5.9e-26 90.2 17.2 0.00074 20.3 0.0 8.6 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV24212.1 - 1.8e-18 66.6 0.2 0.0013 19.0 0.0 7.3 4 2 3 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain LisH PF08513.11 ADV24212.1 - 1.8e-05 24.5 0.5 2.9e-05 23.9 0.5 1.3 1 0 0 1 1 1 1 LisH eIF2A PF08662.11 ADV24212.1 - 0.0025 17.7 0.4 0.015 15.2 0.0 2.5 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ADV24212.1 - 0.033 13.1 0.0 0.18 10.7 0.0 1.9 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein IKI3 PF04762.12 ADV24212.1 - 0.24 9.3 0.0 1.3 7.0 0.0 1.9 2 0 0 2 2 2 0 IKI3 family Fungal_trans PF04082.18 ADV24216.1 - 2.5e-07 30.0 0.2 4.3e-07 29.2 0.2 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ADV24216.1 - 0.0062 16.6 10.6 0.016 15.3 10.6 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Cep3 PF16846.5 ADV24216.1 - 0.021 13.3 0.0 0.034 12.6 0.0 1.2 1 0 0 1 1 1 0 Centromere DNA-binding protein complex CBF3 subunit B DIOX_N PF14226.6 ADV24217.1 - 8.6e-21 74.9 0.0 1.6e-20 74.0 0.0 1.5 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 ADV24217.1 - 5.5e-18 65.3 0.0 1.3e-17 64.1 0.0 1.6 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Homeobox_KN PF05920.11 ADV24218.1 - 1.9e-10 40.4 0.1 3.6e-10 39.6 0.1 1.5 1 0 0 1 1 1 1 Homeobox KN domain KELK PF15796.5 ADV24218.1 - 0.14 12.6 1.3 0.25 11.8 0.4 1.8 2 0 0 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase SWIM PF04434.17 ADV24219.1 - 0.00074 19.1 1.6 0.0028 17.3 1.6 1.9 1 1 0 1 1 1 1 SWIM zinc finger LPD13 PF18825.1 ADV24219.1 - 0.13 12.0 0.0 0.26 11.1 0.0 1.4 1 0 0 1 1 1 0 Large polyvalent protein-associated domain 13 DUF4468 PF14730.6 ADV24221.1 - 0.16 12.3 0.0 0.3 11.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4468) with TBP-like fold Ribosomal_L22e PF01776.17 ADV24223.1 - 1.5e-43 147.6 1.6 1.7e-43 147.4 1.6 1.0 1 0 0 1 1 1 1 Ribosomal L22e protein family PLU-1 PF08429.11 ADV24224.1 - 1.8e-51 175.3 0.3 2.7e-51 174.8 0.3 1.2 1 0 0 1 1 1 1 PLU-1-like protein JmjC PF02373.22 ADV24224.1 - 3.7e-38 130.4 0.3 8.2e-38 129.3 0.3 1.6 1 0 0 1 1 1 1 JmjC domain, hydroxylase PHD PF00628.29 ADV24224.1 - 7.3e-22 77.0 42.0 1e-12 47.7 3.9 4.3 4 0 0 4 4 4 3 PHD-finger JmjN PF02375.17 ADV24224.1 - 4.8e-18 64.8 2.1 1.4e-17 63.4 2.1 1.9 1 0 0 1 1 1 1 jmjN domain zf-C5HC2 PF02928.16 ADV24224.1 - 9.5e-15 54.7 10.7 9.5e-15 54.7 10.7 2.9 3 0 0 3 3 3 1 C5HC2 zinc finger ARID PF01388.21 ADV24224.1 - 2.6e-12 47.2 0.0 5.5e-12 46.2 0.0 1.6 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain PHD_2 PF13831.6 ADV24224.1 - 0.016 14.7 28.9 0.24 11.0 0.5 3.6 3 0 0 3 3 3 0 PHD-finger zf-PHD-like PF15446.6 ADV24224.1 - 0.3 10.7 15.2 0.27 10.8 0.6 3.8 3 0 0 3 3 3 0 PHD/FYVE-zinc-finger like domain Prok-RING_1 PF14446.6 ADV24224.1 - 6.2 6.8 28.4 0.91 9.5 0.7 4.3 4 0 0 4 4 4 0 Prokaryotic RING finger family 1 Slx4 PF09494.10 ADV24225.1 - 6.3e-08 32.5 0.0 1.2e-07 31.5 0.0 1.5 1 0 0 1 1 1 1 Slx4 endonuclease RhoGEF PF00621.20 ADV24226.1 - 6.2e-11 42.9 0.0 1.3e-10 41.8 0.0 1.5 1 0 0 1 1 1 1 RhoGEF domain Glyco_transf_90 PF05686.12 ADV24227.1 - 3.7e-20 72.2 0.2 8.8e-20 71.0 0.2 1.5 1 1 0 1 1 1 1 Glycosyl transferase family 90 PLDc PF00614.22 ADV24228.1 - 4.5e-14 51.9 0.4 2e-06 27.7 0.0 2.6 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_2 PF13091.6 ADV24228.1 - 1.3e-12 47.7 0.0 3e-05 23.9 0.0 2.9 2 1 0 2 2 2 2 PLD-like domain PX PF00787.24 ADV24228.1 - 1.1e-10 41.5 0.2 5.8e-10 39.2 0.0 2.4 2 0 0 2 2 2 1 PX domain PLD_C PF12357.8 ADV24228.1 - 0.046 13.6 0.0 0.12 12.3 0.0 1.7 1 0 0 1 1 1 0 Phospholipase D C terminal Vps26 PF03643.15 ADV24229.1 - 1.1e-51 175.5 0.3 1.4e-51 175.1 0.3 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_C PF02752.22 ADV24229.1 - 0.0026 18.2 0.2 0.0063 17.0 0.1 1.6 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain dCMP_cyt_deam_1 PF00383.23 ADV24231.1 - 2.3e-13 49.9 0.3 5.2e-13 48.7 0.0 1.7 2 0 0 2 2 2 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 ADV24231.1 - 2e-08 34.1 0.0 5.1e-08 32.8 0.0 1.7 1 1 0 1 1 1 1 MafB19-like deaminase XOO_2897-deam PF14440.6 ADV24231.1 - 0.13 12.4 0.1 0.69 10.0 0.0 2.2 1 1 2 3 3 3 0 Xanthomonas XOO_2897-like deaminase Xan_ur_permease PF00860.20 ADV24232.1 - 6.7e-59 199.5 34.0 1.4e-58 198.4 34.0 1.5 1 1 0 1 1 1 1 Permease family SNF2_N PF00176.23 ADV24233.1 - 1.7e-64 217.8 0.3 1.7e-64 217.8 0.3 1.6 2 0 0 2 2 2 1 SNF2 family N-terminal domain DBINO PF13892.6 ADV24233.1 - 4.4e-43 146.8 16.5 4.4e-43 146.8 16.5 3.0 3 0 0 3 3 3 1 DNA-binding domain Helicase_C PF00271.31 ADV24233.1 - 8.2e-16 58.3 0.0 2.6e-15 56.7 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ADV24233.1 - 1.1e-06 28.7 0.0 2.7e-06 27.5 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 ADV24233.1 - 2.7e-05 23.5 0.0 0.0028 16.9 0.0 2.9 2 1 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 Ferric_reduct PF01794.19 ADV24234.1 - 1.2e-20 73.9 7.1 1.2e-20 73.9 7.1 2.7 3 0 0 3 3 3 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 ADV24234.1 - 1.5e-17 64.1 0.0 2.5e-17 63.4 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 ADV24234.1 - 7.1e-17 61.5 0.0 1.6e-16 60.3 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_1 PF00175.21 ADV24234.1 - 0.00059 20.5 0.0 0.31 11.7 0.0 2.5 2 0 0 2 2 2 2 Oxidoreductase NAD-binding domain CoA_binding_3 PF13727.6 ADV24234.1 - 4.7 7.2 12.5 1.4 8.9 0.1 2.4 2 0 0 2 2 2 0 CoA-binding domain zf-BED PF02892.15 ADV24235.1 - 0.0014 18.6 0.5 0.0028 17.6 0.5 1.5 1 0 0 1 1 1 1 BED zinc finger DUF1751 PF08551.10 ADV24236.1 - 5.3e-31 107.1 2.4 1.2e-30 105.9 2.4 1.6 1 0 0 1 1 1 1 Eukaryotic integral membrane protein (DUF1751) Rhomboid PF01694.22 ADV24236.1 - 0.0014 18.6 7.7 0.0035 17.4 7.7 1.6 1 0 0 1 1 1 1 Rhomboid family SE PF08491.10 ADV24237.1 - 1.8e-89 299.5 0.0 8.5e-89 297.3 0.0 1.9 1 1 0 1 1 1 1 Squalene epoxidase DAO PF01266.24 ADV24237.1 - 8.9e-08 32.1 0.0 2.8e-05 23.9 0.0 2.1 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 ADV24237.1 - 8.9e-06 25.2 0.8 0.0068 15.7 0.1 2.6 2 1 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 ADV24237.1 - 0.00075 19.7 0.2 0.0016 18.6 0.2 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 ADV24237.1 - 0.0019 17.3 0.1 0.86 8.6 0.1 2.1 2 0 0 2 2 2 2 FAD binding domain ApbA PF02558.16 ADV24237.1 - 0.004 16.8 0.1 0.0072 16.0 0.1 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Thi4 PF01946.17 ADV24237.1 - 0.0046 16.2 0.1 0.045 13.0 0.0 2.2 2 0 0 2 2 2 1 Thi4 family GIDA PF01134.22 ADV24237.1 - 0.0071 15.5 0.0 0.99 8.4 0.0 2.1 2 0 0 2 2 2 1 Glucose inhibited division protein A Pyr_redox PF00070.27 ADV24237.1 - 0.01 16.4 0.1 0.021 15.4 0.1 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 ADV24237.1 - 0.03 13.5 0.0 0.043 13.0 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase F420_oxidored PF03807.17 ADV24237.1 - 0.041 14.5 0.1 0.093 13.3 0.1 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent NAD_Gly3P_dh_N PF01210.23 ADV24237.1 - 0.044 13.8 0.0 0.072 13.1 0.0 1.3 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus TrkA_N PF02254.18 ADV24237.1 - 0.061 13.6 0.1 0.11 12.7 0.1 1.4 1 0 0 1 1 1 0 TrkA-N domain Shikimate_DH PF01488.20 ADV24237.1 - 0.072 13.2 0.0 0.12 12.5 0.0 1.2 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Sacchrp_dh_NADP PF03435.18 ADV24237.1 - 0.11 12.8 0.1 0.19 12.0 0.1 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Pyr_redox_3 PF13738.6 ADV24237.1 - 0.13 11.5 0.1 0.19 10.9 0.1 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 ADV24237.1 - 0.13 12.1 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Histidinol_dh PF00815.20 ADV24238.1 - 1.7e-163 544.4 1.0 2.5e-163 543.8 1.0 1.3 1 0 0 1 1 1 1 Histidinol dehydrogenase PRA-CH PF01502.18 ADV24238.1 - 2.8e-23 81.5 0.1 6.5e-23 80.4 0.1 1.7 1 0 0 1 1 1 1 Phosphoribosyl-AMP cyclohydrolase PRA-PH PF01503.17 ADV24238.1 - 8.4e-13 48.6 0.3 2.9e-12 46.9 0.2 2.1 2 0 0 2 2 2 1 Phosphoribosyl-ATP pyrophosphohydrolase PMT PF02366.18 ADV24240.1 - 6.4e-79 265.0 14.9 1.3e-78 263.9 14.9 1.5 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 ADV24240.1 - 4.8e-65 218.9 15.7 1e-64 217.8 15.7 1.6 1 0 0 1 1 1 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 ADV24240.1 - 1.2e-38 132.8 0.1 4.5e-38 131.0 0.0 1.9 2 1 1 3 3 3 1 MIR domain DUF2628 PF10947.8 ADV24240.1 - 0.031 14.6 1.9 0.12 12.8 1.9 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2628) GFO_IDH_MocA PF01408.22 ADV24241.1 - 1.8e-18 67.5 0.0 3.2e-18 66.7 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ADV24241.1 - 1.3e-14 54.2 0.8 2.4e-14 53.4 0.2 1.8 2 0 0 2 2 2 1 Oxidoreductase family, C-terminal alpha/beta domain PEMT PF04191.13 ADV24242.1 - 2.7e-33 114.5 2.5 5.7e-33 113.5 2.5 1.5 1 0 0 1 1 1 1 Phospholipid methyltransferase ICMT PF04140.14 ADV24242.1 - 0.014 15.8 0.5 0.032 14.6 0.5 1.6 1 0 0 1 1 1 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family Anillin_N PF16018.5 ADV24242.1 - 0.15 12.7 1.8 0.22 12.1 1.3 1.5 1 1 0 1 1 1 0 Anillin N-terminus GTP_EFTU PF00009.27 ADV24243.1 - 1.1e-64 217.6 0.0 1.5e-64 217.2 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 ADV24243.1 - 8.3e-32 109.5 0.0 2.1e-31 108.2 0.0 1.7 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.24 ADV24243.1 - 1e-19 70.4 0.0 2.1e-19 69.3 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 ADV24243.1 - 9.8e-13 48.0 0.0 2.2e-12 46.9 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 ADV24243.1 - 8e-12 45.4 0.2 3.2e-11 43.5 0.0 2.1 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 ADV24243.1 - 6.2e-05 23.0 0.2 0.00043 20.3 0.1 2.2 2 0 0 2 2 2 1 50S ribosome-binding GTPase PduV-EutP PF10662.9 ADV24243.1 - 0.089 12.5 0.1 0.45 10.3 0.0 2.0 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation DDE_Tnp_4 PF13359.6 ADV24245.1 - 2e-12 47.1 0.0 4.8e-12 45.8 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease Plant_tran PF04827.14 ADV24245.1 - 4.9e-05 23.0 0.0 7.7e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Plant transposon protein tRNA-synt_2 PF00152.20 ADV24246.1 - 6.8e-78 261.9 0.0 1.2e-77 261.1 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 ADV24246.1 - 1.3e-05 25.1 0.1 2.3e-05 24.3 0.1 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain Methyltransf_7 PF03492.15 ADV24246.1 - 0.015 14.5 0.1 0.028 13.6 0.1 1.3 1 0 0 1 1 1 0 SAM dependent carboxyl methyltransferase NARP1 PF12569.8 ADV24246.1 - 0.67 8.8 7.5 0.99 8.2 7.5 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 RNA_pol_Rpc4 PF05132.14 ADV24246.1 - 0.81 10.1 7.3 0.99 9.8 6.1 1.8 2 0 0 2 2 2 0 RNA polymerase III RPC4 Spore_coat_CotO PF14153.6 ADV24246.1 - 1.2 9.0 8.0 2.3 8.1 8.0 1.4 1 0 0 1 1 1 0 Spore coat protein CotO TRAPPC9-Trs120 PF08626.11 ADV24248.1 - 5.8e-10 37.2 18.0 1.2e-07 29.5 3.7 4.5 3 2 0 4 4 4 3 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit FXMRP1_C_core PF12235.8 ADV24248.1 - 2 9.0 6.9 8.1 7.1 6.9 2.0 1 0 0 1 1 1 0 Fragile X-related 1 protein core C terminal TRAPPC9-Trs120 PF08626.11 ADV24249.1 - 1.5e-93 314.1 0.0 1.7e-93 313.9 0.0 1.0 1 0 0 1 1 1 1 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit TFIID_20kDa PF03847.13 ADV24250.1 - 1.3e-13 51.3 2.5 6.7e-13 48.9 1.3 2.4 2 0 0 2 2 2 1 Transcription initiation factor TFIID subunit A Histone PF00125.24 ADV24250.1 - 0.069 13.5 0.2 0.069 13.5 0.2 2.8 2 0 0 2 2 2 0 Core histone H2A/H2B/H3/H4 Tma16 PF11176.8 ADV24251.1 - 5.3e-38 130.2 0.0 6.6e-38 129.9 0.0 1.1 1 0 0 1 1 1 1 Translation machinery-associated protein 16 Rhodanese PF00581.20 ADV24252.1 - 9.9e-06 26.0 0.0 1.4e-05 25.5 0.0 1.3 1 0 0 1 1 1 1 Rhodanese-like domain DUF1479 PF07350.12 ADV24254.1 - 2.9e-154 513.8 0.0 3.3e-154 513.6 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1479) PhyH PF05721.13 ADV24254.1 - 0.00015 22.1 0.2 0.029 14.6 0.1 2.4 2 0 0 2 2 2 2 Phytanoyl-CoA dioxygenase (PhyH) RNA_pol PF00940.19 ADV24255.1 - 2e-176 586.9 0.0 2.8e-176 586.4 0.0 1.2 1 0 0 1 1 1 1 DNA-dependent RNA polymerase RPOL_N PF14700.6 ADV24255.1 - 8.6e-89 298.2 1.4 1.3e-88 297.7 1.4 1.3 1 0 0 1 1 1 1 DNA-directed RNA polymerase N-terminal Myosin_head PF00063.21 ADV24256.1 - 2.4e-224 746.5 0.0 3.6e-224 745.9 0.0 1.2 1 0 0 1 1 1 1 Myosin head (motor domain) DIL PF01843.19 ADV24256.1 - 4.4e-24 84.8 3.3 4.4e-24 84.8 3.3 2.6 2 0 0 2 2 2 1 DIL domain IQ PF00612.27 ADV24256.1 - 5.1e-18 63.1 28.2 0.00059 19.4 0.1 7.0 7 0 0 7 7 7 6 IQ calmodulin-binding motif TPR_10 PF13374.6 ADV24256.1 - 0.096 12.6 0.0 0.31 11.0 0.0 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat STE3 PF02076.15 ADV24257.1 - 7.9e-91 304.3 13.0 9.1e-91 304.1 13.0 1.0 1 0 0 1 1 1 1 Pheromone A receptor Pkinase PF00069.25 ADV24258.1 - 2.4e-41 141.9 0.0 6e-28 97.9 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ADV24258.1 - 3.3e-24 85.6 0.0 4.8e-24 85.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ADV24258.1 - 0.00052 18.9 0.0 0.00083 18.2 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 ADV24258.1 - 0.019 14.3 0.0 0.028 13.7 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Pheromone PF08015.11 ADV24259.1 - 0.00062 20.8 2.6 0.06 14.4 0.2 2.0 1 1 1 2 2 2 2 Fungal mating-type pheromone eIF2A PF08662.11 ADV24260.1 - 2.3e-32 112.4 0.2 1.5e-30 106.5 0.1 3.6 3 1 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A RRM_1 PF00076.22 ADV24260.1 - 5.6e-09 35.7 0.0 1.5e-08 34.3 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF5604 PF18300.1 ADV24260.1 - 0.028 14.4 0.1 0.07 13.1 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF5604) AviRa PF11599.8 ADV24260.1 - 0.21 11.0 0.4 0.35 10.3 0.4 1.3 1 0 0 1 1 1 0 RRNA methyltransferase AviRa WD40 PF00400.32 ADV24260.1 - 1.5 9.8 9.6 1.9 9.5 0.0 4.4 5 0 0 5 5 5 0 WD domain, G-beta repeat Pheromone PF08015.11 ADV24261.1 - 0.00062 20.8 2.6 0.06 14.4 0.2 2.0 1 1 1 2 2 2 2 Fungal mating-type pheromone CAP_GLY PF01302.25 ADV24262.1 - 0.00012 22.0 0.6 0.00057 19.8 0.2 2.3 2 1 0 2 2 2 1 CAP-Gly domain NGP1NT PF08153.12 ADV24264.1 - 1.2e-50 171.0 0.0 3e-50 169.7 0.0 1.7 1 0 0 1 1 1 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.23 ADV24264.1 - 9.2e-17 61.2 0.0 2.4e-13 50.2 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.18 ADV24264.1 - 2.8e-05 23.7 0.1 0.00015 21.3 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B Arf PF00025.21 ADV24264.1 - 0.00025 20.5 0.1 0.075 12.5 0.0 2.4 2 0 0 2 2 2 2 ADP-ribosylation factor family RsgA_GTPase PF03193.16 ADV24264.1 - 0.0086 16.0 0.0 0.027 14.4 0.0 1.8 1 1 0 1 1 1 1 RsgA GTPase BUD22 PF09073.10 ADV24264.1 - 0.027 13.8 30.0 0.048 13.0 30.0 1.4 1 0 0 1 1 1 0 BUD22 SDA1 PF05285.12 ADV24264.1 - 0.62 9.4 33.1 1.1 8.6 33.1 1.4 1 0 0 1 1 1 0 SDA1 DNA_pol_phi PF04931.13 ADV24264.1 - 7.1 4.6 31.1 11 4.0 31.1 1.2 1 0 0 1 1 1 0 DNA polymerase phi Pantoate_ligase PF02569.15 ADV24265.1 - 3.4e-82 275.7 0.0 6.9e-82 274.6 0.0 1.5 1 1 0 1 1 1 1 Pantoate-beta-alanine ligase RNA_pol_Rpb4 PF03874.16 ADV24267.1 - 8.5e-08 32.6 0.1 1.2e-06 28.9 0.0 2.1 1 1 0 2 2 2 1 RNA polymerase Rpb4 IPP-2 PF04979.14 ADV24268.1 - 0.53 11.0 0.1 0.53 11.0 0.1 4.0 2 2 1 3 3 3 0 Protein phosphatase inhibitor 2 (IPP-2) WD40 PF00400.32 ADV24269.1 - 2.7e-34 116.6 13.0 1.2e-08 35.4 0.1 8.1 7 1 0 7 7 7 7 WD domain, G-beta repeat PRP4 PF08799.11 ADV24269.1 - 8.6e-14 50.8 1.5 8.6e-14 50.8 1.5 2.5 2 0 0 2 2 2 1 pre-mRNA processing factor 4 (PRP4) like ANAPC4_WD40 PF12894.7 ADV24269.1 - 2.6e-10 40.5 0.0 0.0046 17.2 0.0 4.6 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ADV24269.1 - 0.00012 21.5 0.0 0.012 15.0 0.0 2.8 3 0 0 3 3 3 1 WD40-like domain Nbas_N PF15492.6 ADV24269.1 - 0.02 14.2 0.0 4.4 6.5 0.0 3.2 3 0 0 3 3 3 0 Neuroblastoma-amplified sequence, N terminal Ge1_WD40 PF16529.5 ADV24269.1 - 0.092 11.7 0.0 25 3.7 0.0 3.0 3 0 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein KH_8 PF17903.1 ADV24270.1 - 7.7e-31 106.0 0.0 6.9e-30 103.0 0.0 2.3 2 0 0 2 2 2 1 Krr1 KH1 domain KH_1 PF00013.29 ADV24270.1 - 0.0035 17.1 0.0 0.0065 16.3 0.0 1.4 1 0 0 1 1 1 1 KH domain tRNA-synt_2b PF00587.25 ADV24271.1 - 2.9e-35 121.9 0.0 4.8e-35 121.1 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 ADV24271.1 - 2.4e-18 66.3 7.1 2.4e-18 66.3 7.1 1.6 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain Phage_GP20 PF06810.11 ADV24271.1 - 0.16 11.8 7.1 0.2 11.4 5.9 1.7 2 0 0 2 2 2 0 Phage minor structural protein GP20 nsp8 PF08717.10 ADV24271.1 - 0.25 11.2 1.5 0.39 10.6 1.5 1.2 1 0 0 1 1 1 0 nsp8 replicase PEARLI-4 PF05278.12 ADV24271.1 - 0.53 9.8 3.9 0.8 9.2 3.9 1.2 1 0 0 1 1 1 0 Arabidopsis phospholipase-like protein (PEARLI 4) Homeodomain PF00046.29 ADV24272.1 - 1.7e-06 27.8 0.3 4.5e-06 26.4 0.3 1.8 1 0 0 1 1 1 1 Homeodomain eIF-5a PF01287.20 ADV24273.1 - 1.2e-28 99.0 0.8 1.7e-28 98.5 0.8 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.12 ADV24273.1 - 0.0079 16.2 0.1 0.014 15.4 0.1 1.5 1 0 0 1 1 1 1 Elongation factor P (EF-P) KOW-like domain ATG11 PF10377.9 ADV24274.1 - 3.7e-05 23.8 0.2 3.7e-05 23.8 0.2 4.0 3 1 0 3 3 3 1 Autophagy-related protein 11 FemAB_like PF04339.12 ADV24274.1 - 0.29 10.2 4.8 0.75 8.8 4.8 1.7 1 0 0 1 1 1 0 Peptidogalycan biosysnthesis/recognition PI_PP_I PF18363.1 ADV24274.1 - 0.87 9.8 3.5 6.8 6.9 0.3 3.5 2 0 0 2 2 2 0 Phosphoinositide phosphatase insertion domain Filament PF00038.21 ADV24274.1 - 1 8.9 65.0 0.72 9.4 15.1 5.0 2 2 2 4 4 4 0 Intermediate filament protein Baculo_PEP_C PF04513.12 ADV24274.1 - 1.8 8.6 36.4 0.059 13.4 1.7 7.2 7 2 1 8 8 8 0 Baculovirus polyhedron envelope protein, PEP, C terminus Cas_GSU0053 PF09617.10 ADV24274.1 - 2.4 8.1 6.3 3 7.8 0.0 3.2 3 0 0 3 3 3 0 CRISPR-associated protein GSU0053 (Cas_GSU0053) Mem_trans PF03547.18 ADV24275.1 - 1.2e-42 145.8 0.7 3.3e-35 121.2 0.0 2.4 2 1 0 2 2 2 2 Membrane transport protein SBF PF01758.16 ADV24275.1 - 0.01 15.5 1.0 0.01 15.5 1.0 3.3 4 0 0 4 4 4 0 Sodium Bile acid symporter family ATP-synt_Z PF16594.5 ADV24275.1 - 0.035 13.6 1.1 0.14 11.7 1.1 2.1 1 0 0 1 1 1 0 Putative AtpZ or ATP-synthase-associated IQ PF00612.27 ADV24275.1 - 0.14 12.0 0.3 0.36 10.8 0.3 1.7 1 0 0 1 1 1 0 IQ calmodulin-binding motif Mid2 PF04478.12 ADV24276.1 - 3.8e-05 23.6 0.0 3.8e-05 23.6 0.0 3.4 3 0 0 3 3 3 1 Mid2 like cell wall stress sensor Phage_holin_2_4 PF16082.5 ADV24276.1 - 0.38 10.5 1.7 0.98 9.2 0.0 2.6 2 0 0 2 2 2 0 Bacteriophage holin family, superfamily II-like RNase_PH PF01138.21 ADV24277.1 - 7e-29 101.0 0.1 1.2e-28 100.2 0.1 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 ADV24277.1 - 0.0026 17.7 0.0 0.0051 16.8 0.0 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Thioredoxin_4 PF13462.6 ADV24278.1 - 5.9e-06 26.5 0.0 4.9e-05 23.6 0.0 1.9 1 1 0 1 1 1 1 Thioredoxin Membr_traf_MHD PF10540.9 ADV24279.1 - 2.3e-17 63.5 3.2 4e-09 36.8 0.2 3.0 2 1 1 3 3 3 2 Munc13 (mammalian uncoordinated) homology domain C2 PF00168.30 ADV24279.1 - 3.9e-14 52.8 0.0 8.9e-14 51.6 0.0 1.5 1 0 0 1 1 1 1 C2 domain DUF810 PF05664.11 ADV24279.1 - 6.2e-06 25.1 0.1 1e-05 24.4 0.1 1.3 1 0 0 1 1 1 1 Plant family of unknown function (DUF810) DOCK-C2 PF14429.6 ADV24279.1 - 0.0086 15.9 0.0 0.027 14.3 0.0 1.8 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins RRM_1 PF00076.22 ADV24280.1 - 5.2e-54 180.0 0.0 1.5e-19 69.6 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ADV24280.1 - 4.4e-11 42.5 0.0 0.00018 21.1 0.0 3.1 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ADV24280.1 - 9.5e-05 22.2 0.0 0.012 15.5 0.0 3.0 3 0 0 3 3 3 1 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 ADV24280.1 - 0.00037 20.4 0.1 1.5 8.9 0.0 3.3 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif Cas_Cas2CT1978 PF09707.10 ADV24280.1 - 0.0073 16.3 0.0 5.8 7.1 0.0 3.0 3 0 0 3 3 3 2 CRISPR-associated protein (Cas_Cas2CT1978) RRM_7 PF16367.5 ADV24280.1 - 0.018 15.2 0.2 0.24 11.6 0.0 2.8 3 1 0 3 3 3 0 RNA recognition motif PHM7_cyt PF14703.6 ADV24280.1 - 0.064 13.5 0.0 30 4.8 0.0 3.0 3 0 0 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter LNS2 PF08235.13 ADV24281.1 - 3.6e-98 327.6 0.0 6.2e-98 326.8 0.0 1.4 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.14 ADV24281.1 - 2.2e-30 104.6 0.0 3.8e-30 103.9 0.0 1.4 1 0 0 1 1 1 1 lipin, N-terminal conserved region Lipin_mid PF16876.5 ADV24281.1 - 4.4e-12 46.0 0.0 8e-12 45.2 0.0 1.5 1 0 0 1 1 1 1 Lipin/Ned1/Smp2 multi-domain protein middle domain Acid_phosphat_B PF03767.14 ADV24281.1 - 0.029 13.9 0.0 0.3 10.6 0.0 2.3 3 0 0 3 3 3 0 HAD superfamily, subfamily IIIB (Acid phosphatase) WRNPLPNID PF15017.6 ADV24281.1 - 9.7 7.2 15.0 0.39 11.6 0.7 4.2 3 0 0 3 3 3 0 Putative WW-binding domain and destruction box Sec7 PF01369.20 ADV24282.1 - 6.1e-27 94.5 0.3 1.3e-26 93.4 0.3 1.5 1 0 0 1 1 1 1 Sec7 domain PH_9 PF15410.6 ADV24282.1 - 2e-18 66.9 0.0 6.9e-18 65.1 0.0 2.0 2 0 0 2 2 2 1 Pleckstrin homology domain PH PF00169.29 ADV24282.1 - 0.0001 22.7 0.0 0.00034 21.1 0.0 1.9 1 0 0 1 1 1 1 PH domain DUF2256 PF10013.9 ADV24283.1 - 0.025 14.7 0.4 0.025 14.7 0.4 2.5 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2256) DUF2321 PF10083.9 ADV24283.1 - 0.029 14.0 1.5 0.046 13.3 0.1 1.7 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2321) HSP70 PF00012.20 ADV24285.1 - 7.4e-64 216.0 0.4 2.8e-51 174.4 0.2 2.2 2 0 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 ADV24285.1 - 0.00035 19.5 0.1 0.17 10.7 0.0 2.6 2 1 0 2 2 2 2 MreB/Mbl protein PilM_2 PF11104.8 ADV24285.1 - 0.025 13.6 0.0 3.3 6.6 0.0 2.2 2 0 0 2 2 2 0 Type IV pilus assembly protein PilM; DUF86 PF01934.17 ADV24285.1 - 0.1 12.5 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF86 GET2 PF08690.10 ADV24287.1 - 0.00021 21.1 7.6 0.051 13.2 3.0 2.4 2 1 0 2 2 2 2 GET complex subunit GET2 rRNA_proc-arch PF13234.6 ADV24288.1 - 2.8e-82 276.7 0.1 5.5e-82 275.7 0.1 1.5 1 0 0 1 1 1 1 rRNA-processing arch domain DSHCT PF08148.12 ADV24288.1 - 7.4e-55 185.1 1.3 1.5e-54 184.0 1.3 1.6 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.29 ADV24288.1 - 5.6e-18 65.3 0.0 4.7e-17 62.3 0.0 2.4 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ADV24288.1 - 4.6e-06 27.0 0.0 4.2e-05 23.8 0.0 2.4 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 ADV24288.1 - 1.6e-05 25.0 0.0 3.7e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF3638 PF12340.8 ADV24288.1 - 0.067 12.5 0.1 1.1 8.5 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3638) DUF4239 PF14023.6 ADV24288.1 - 0.19 11.4 0.7 3.2 7.4 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF4239) DAHP_synth_1 PF00793.20 ADV24289.1 - 3.6e-96 321.2 0.0 4.5e-96 320.9 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family Actin PF00022.19 ADV24290.1 - 4.8e-91 305.4 0.0 7.5e-90 301.5 0.0 1.9 1 1 0 1 1 1 1 Actin KilA-N PF04383.13 ADV24290.1 - 0.17 11.7 0.0 14 5.5 0.0 2.2 2 0 0 2 2 2 0 KilA-N domain EMP24_GP25L PF01105.24 ADV24291.1 - 1.7e-47 161.7 0.1 1.9e-47 161.5 0.1 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD TSC22 PF01166.18 ADV24291.1 - 0.088 13.1 0.1 0.17 12.2 0.1 1.4 1 0 0 1 1 1 0 TSC-22/dip/bun family Cullin_binding PF03556.15 ADV24292.1 - 1.1e-34 119.4 0.4 1.7e-34 118.8 0.4 1.3 1 0 0 1 1 1 1 Cullin binding UBA_4 PF14555.6 ADV24292.1 - 0.001 18.9 0.4 0.0054 16.5 0.4 2.1 1 1 0 1 1 1 1 UBA-like domain DUF3669 PF12417.8 ADV24292.1 - 0.068 13.4 0.0 0.19 12.0 0.0 1.8 1 0 0 1 1 1 0 Zinc finger protein Clat_adaptor_s PF01217.20 ADV24293.1 - 1.4e-06 28.3 0.0 1.9e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 Clathrin adaptor complex small chain DUF1574 PF07611.11 ADV24293.1 - 0.061 12.7 0.0 0.079 12.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1574) DUF4337 PF14235.6 ADV24293.1 - 0.2 11.7 1.8 0.32 11.1 1.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) RNA_Me_trans PF04252.13 ADV24294.1 - 8e-82 273.7 0.0 9e-82 273.5 0.0 1.0 1 0 0 1 1 1 1 Predicted SAM-dependent RNA methyltransferase CALM_bind PF16025.5 ADV24294.1 - 0.043 14.3 0.0 0.09 13.3 0.0 1.5 1 0 0 1 1 1 0 Calcium-dependent calmodulin binding F-box-like PF12937.7 ADV24295.1 - 0.13 12.2 0.1 0.31 10.9 0.1 1.7 1 0 0 1 1 1 0 F-box-like DUF2013 PF09431.10 ADV24296.1 - 8.3e-52 175.0 1.0 3.7e-51 172.9 1.0 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF2013) SAE2 PF08573.10 ADV24298.1 - 0.083 14.0 6.8 0.2 12.8 6.8 1.7 1 0 0 1 1 1 0 DNA repair protein endonuclease SAE2/CtIP C-terminus Presenilin PF01080.17 ADV24298.1 - 6.6 5.4 6.4 9.5 4.9 6.4 1.2 1 0 0 1 1 1 0 Presenilin V_ATPase_I PF01496.19 ADV24298.1 - 7.8 4.3 5.6 11 3.7 5.6 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Vps26 PF03643.15 ADV24300.1 - 1e-123 411.8 4.0 1.2e-123 411.5 4.0 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_C PF02752.22 ADV24300.1 - 0.0044 17.5 0.2 2.1 8.8 0.0 2.9 2 1 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 ADV24300.1 - 0.051 13.6 1.1 0.28 11.2 0.1 2.6 3 1 1 4 4 4 0 Arrestin (or S-antigen), N-terminal domain Bromo_TP PF07524.13 ADV24301.1 - 2.4e-06 27.5 0.1 4.3e-06 26.7 0.1 1.4 1 0 0 1 1 1 1 Bromodomain associated DASH_Duo1 PF08651.10 ADV24302.1 - 3.8e-23 81.0 0.0 6.2e-23 80.4 0.0 1.3 1 0 0 1 1 1 1 DASH complex subunit Duo1 WD40 PF00400.32 ADV24303.1 - 3.2e-64 211.3 18.1 2.8e-08 34.3 0.3 8.8 8 1 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV24303.1 - 1.8e-19 69.8 1.7 0.0023 18.2 0.0 5.7 3 3 2 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ADV24303.1 - 4e-08 32.4 1.2 0.15 10.6 0.3 4.5 4 1 1 6 6 6 3 Nucleoporin Nup120/160 NLE PF08154.12 ADV24303.1 - 2.6e-07 31.1 0.0 5.3e-07 30.1 0.0 1.5 1 0 0 1 1 1 1 NLE (NUC135) domain eIF2A PF08662.11 ADV24303.1 - 1.6e-06 28.2 0.0 0.0001 22.3 0.0 2.9 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ADV24303.1 - 0.00026 20.0 0.1 0.37 9.7 0.0 4.2 4 2 2 6 6 6 1 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ADV24303.1 - 0.0074 15.7 0.0 0.61 9.4 0.0 2.5 3 0 0 3 3 3 1 WD40-like domain IKI3 PF04762.12 ADV24303.1 - 0.017 13.1 0.0 0.024 12.7 0.0 1.2 1 0 0 1 1 1 0 IKI3 family PD40 PF07676.12 ADV24303.1 - 0.15 12.1 0.0 3.3 7.7 0.0 2.9 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat LBP_M PF17385.2 ADV24304.1 - 0.12 11.9 0.1 0.39 10.2 0.0 1.7 2 0 0 2 2 2 0 Lacto-N-biose phosphorylase central domain VID27_PH PF17747.1 ADV24305.1 - 0.13 12.5 0.1 0.25 11.7 0.1 1.4 1 0 0 1 1 1 0 VID27 PH-like domain TUG-UBL1 PF11470.8 ADV24305.1 - 0.14 12.4 0.0 0.39 11.0 0.0 1.8 1 0 0 1 1 1 0 TUG ubiquitin-like domain Metallophos PF00149.28 ADV24306.1 - 6.5e-36 124.8 0.0 8.1e-36 124.4 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Glyco_hydro_65N PF03636.15 ADV24306.1 - 0.012 15.3 0.0 0.018 14.7 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain Ank_2 PF12796.7 ADV24307.1 - 4e-11 43.3 0.2 0.00021 21.8 0.0 2.7 2 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ADV24307.1 - 1.4e-09 38.3 0.4 5.3e-07 30.1 0.1 3.4 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 ADV24307.1 - 8.7e-09 34.9 2.7 0.00026 21.2 0.1 3.8 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 ADV24307.1 - 4.6e-06 26.8 0.5 0.049 14.0 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 ADV24307.1 - 1.2e-05 25.6 5.2 0.18 12.3 0.1 3.7 4 0 0 4 4 4 2 Ankyrin repeat KilA-N PF04383.13 ADV24307.1 - 7.3e-05 22.6 0.1 0.00052 19.8 0.1 2.1 1 1 0 1 1 1 1 KilA-N domain Exonuc_VII_L PF02601.15 ADV24307.1 - 0.074 12.6 4.1 0.055 13.0 2.3 1.6 2 0 0 2 2 2 0 Exonuclease VII, large subunit Vps54_N PF10475.9 ADV24307.1 - 0.3 10.3 2.2 2.6 7.2 2.2 2.0 2 0 0 2 2 2 0 Vacuolar-sorting protein 54, of GARP complex Maf1 PF09174.10 ADV24308.1 - 3e-33 115.4 0.2 2.9e-24 86.2 0.0 2.3 2 0 0 2 2 2 2 Maf1 regulator Aminotran_5 PF00266.19 ADV24309.1 - 3.1e-85 286.4 0.0 3.7e-85 286.1 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 ADV24309.1 - 5.9e-06 25.8 0.0 9.2e-06 25.1 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Suc_Fer-like PF06999.12 ADV24310.1 - 1.5e-22 80.4 0.0 2.2e-22 79.9 0.0 1.2 1 0 0 1 1 1 1 Sucrase/ferredoxin-like Fer2 PF00111.27 ADV24310.1 - 3.5e-07 30.1 0.2 7.4e-07 29.0 0.2 1.6 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain APG9 PF04109.16 ADV24311.1 - 2.4e-215 716.1 4.8 2.8e-215 715.8 4.8 1.0 1 0 0 1 1 1 1 Autophagy protein Apg9 HSP9_HSP12 PF04119.12 ADV24312.1 - 3e-24 85.1 4.7 3.5e-24 84.9 4.7 1.1 1 0 0 1 1 1 1 Heat shock protein 9/12 STE PF02200.16 ADV24314.1 - 1.2e-51 173.8 0.0 2e-51 173.0 0.0 1.4 1 0 0 1 1 1 1 STE like transcription factor zf-H2C2_2 PF13465.6 ADV24314.1 - 2.2e-07 31.0 3.8 2.2e-07 31.0 3.8 3.1 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2 PF00096.26 ADV24314.1 - 6.8e-07 29.4 19.1 0.0022 18.4 1.9 4.1 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ADV24314.1 - 2.3e-06 28.0 11.4 0.0062 17.3 1.7 3.3 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 ADV24314.1 - 0.013 15.5 4.5 0.013 15.5 4.5 3.0 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_8 PF15909.5 ADV24314.1 - 0.031 14.6 0.8 0.031 14.6 0.8 1.9 2 0 0 2 2 2 0 C2H2-type zinc ribbon HNH PF01844.23 ADV24314.1 - 0.046 13.9 1.0 0.1 12.8 1.0 1.6 1 0 0 1 1 1 0 HNH endonuclease zf-C2H2_jaz PF12171.8 ADV24314.1 - 1 9.7 5.8 28 5.1 0.0 3.3 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2HE PF16278.5 ADV24314.1 - 3.6 8.1 5.9 4.1 7.9 0.3 2.5 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger Ribosomal_L39 PF00832.20 ADV24315.1 - 2.7e-22 78.1 12.3 3e-22 78.0 12.3 1.1 1 0 0 1 1 1 1 Ribosomal L39 protein Nmad3 PF18754.1 ADV24315.1 - 0.09 12.3 0.5 0.087 12.4 0.5 1.0 1 0 0 1 1 1 0 Nucleotide modification associated domain 3 Pheromone PF08015.11 ADV24316.1 - 0.00062 20.8 2.6 0.06 14.4 0.2 2.0 1 1 1 2 2 2 2 Fungal mating-type pheromone zf-HC5HC2H_2 PF13832.6 ADV24317.1 - 4.1e-17 62.3 0.2 4.1e-17 62.3 0.2 4.3 3 1 0 3 3 3 2 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 ADV24317.1 - 4.2e-13 49.4 0.3 4.2e-13 49.4 0.3 5.0 5 1 0 5 5 5 2 PHD-like zinc-binding domain BAH PF01426.18 ADV24317.1 - 1.4e-11 44.3 0.0 3e-11 43.3 0.0 1.5 1 0 0 1 1 1 1 BAH domain PHD PF00628.29 ADV24317.1 - 2.9e-09 36.7 64.7 2.4e-07 30.5 12.1 5.4 7 0 0 7 7 7 3 PHD-finger PHD_2 PF13831.6 ADV24317.1 - 2.6e-06 26.9 9.6 9.4e-06 25.1 5.4 5.6 5 0 0 5 5 5 3 PHD-finger C1_2 PF03107.16 ADV24317.1 - 0.0042 17.4 2.4 0.0042 17.4 2.4 7.0 7 0 0 7 7 7 2 C1 domain GATA PF00320.27 ADV24317.1 - 0.83 9.3 26.3 0.11 12.2 0.5 5.0 5 0 0 5 5 5 0 GATA zinc finger Pheromone PF08015.11 ADV24318.1 - 0.00062 20.8 2.6 0.06 14.4 0.2 2.0 1 1 1 2 2 2 2 Fungal mating-type pheromone ETF PF01012.21 ADV24319.1 - 4.2e-41 140.8 1.4 7e-41 140.1 1.4 1.4 1 0 0 1 1 1 1 Electron transfer flavoprotein domain ETF_alpha PF00766.19 ADV24319.1 - 9.9e-34 115.2 0.5 2.3e-33 114.1 0.5 1.6 1 0 0 1 1 1 1 Electron transfer flavoprotein FAD-binding domain Pkinase PF00069.25 ADV24321.1 - 1.6e-71 240.8 0.1 2.8e-71 240.0 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV24321.1 - 1.3e-50 172.1 0.2 2.7e-50 171.1 0.2 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 ADV24321.1 - 8.2e-24 83.7 0.0 2.1e-23 82.4 0.0 1.8 1 0 0 1 1 1 1 P21-Rho-binding domain PH PF00169.29 ADV24321.1 - 1.3e-11 45.0 0.0 2.5e-11 44.0 0.0 1.5 1 0 0 1 1 1 1 PH domain Kinase-like PF14531.6 ADV24321.1 - 3.8e-07 29.7 0.0 8.3e-07 28.6 0.0 1.5 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 ADV24321.1 - 2.8e-06 26.4 0.0 5.4e-06 25.4 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 ADV24321.1 - 0.0011 18.9 0.0 0.015 15.3 0.0 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family BCL_N PF04714.13 ADV24321.1 - 0.03 14.4 0.1 0.097 12.7 0.1 1.9 1 0 0 1 1 1 0 BCL7, N-terminal conserver region Kdo PF06293.14 ADV24321.1 - 0.054 12.8 0.2 0.15 11.4 0.1 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family PH_11 PF15413.6 ADV24321.1 - 0.098 13.1 0.1 0.79 10.2 0.1 2.4 1 1 0 1 1 1 0 Pleckstrin homology domain Haspin_kinase PF12330.8 ADV24321.1 - 0.18 10.7 0.8 0.57 9.1 0.9 1.6 1 1 0 1 1 1 0 Haspin like kinase domain Pkinase PF00069.25 ADV24322.1 - 8.7e-70 235.1 0.0 1.3e-69 234.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV24322.1 - 1.7e-46 158.6 0.0 2.7e-46 157.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ras_bdg_2 PF14847.6 ADV24322.1 - 6.8e-12 45.6 0.0 1.4e-11 44.6 0.0 1.5 1 0 0 1 1 1 1 Ras-binding domain of Byr2 SAM_1 PF00536.30 ADV24322.1 - 1.3e-07 32.0 0.1 2.6e-07 31.0 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ADV24322.1 - 2e-06 27.8 0.1 5.4e-06 26.4 0.1 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Kinase-like PF14531.6 ADV24322.1 - 9e-06 25.2 0.0 7e-05 22.3 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 ADV24322.1 - 0.024 13.4 0.0 0.087 11.6 0.0 1.7 2 1 0 2 2 2 0 Fungal protein kinase DUF4637 PF15470.6 ADV24322.1 - 0.098 12.4 3.4 0.21 11.3 3.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) BSP_II PF05432.11 ADV24322.1 - 0.18 11.5 14.9 0.011 15.4 9.6 1.6 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) Kdo PF06293.14 ADV24322.1 - 0.19 11.1 0.0 0.4 10.0 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Paf1 PF03985.13 ADV24322.1 - 5.3 5.9 11.1 9.5 5.1 11.1 1.3 1 0 0 1 1 1 0 Paf1 DUF4746 PF15928.5 ADV24322.1 - 5.9 6.2 7.4 10 5.4 7.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) HEAT_2 PF13646.6 ADV24323.1 - 1.1e-05 25.7 2.0 3.3 8.2 0.1 5.5 4 1 0 4 4 4 3 HEAT repeats HEAT PF02985.22 ADV24323.1 - 0.0033 17.5 4.1 36 5.0 0.0 6.3 7 0 0 7 7 7 1 HEAT repeat Arm PF00514.23 ADV24323.1 - 0.49 10.5 12.0 0.51 10.5 0.0 5.7 7 0 0 7 7 7 0 Armadillo/beta-catenin-like repeat Adaptin_binding PF10199.9 ADV24325.1 - 1.1 9.9 8.7 19 5.9 8.7 2.4 1 1 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 Pribosyltran PF00156.27 ADV24326.1 - 3.7e-16 59.0 0.0 4.5e-16 58.8 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 ADV24326.1 - 0.0075 15.7 0.0 0.011 15.3 0.0 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase DinB_2 PF12867.7 ADV24327.1 - 0.85 10.1 7.0 5.8 7.4 3.5 3.3 2 1 0 2 2 2 0 DinB superfamily UPF0014 PF03649.13 ADV24328.1 - 7.5e-72 241.6 20.8 8.6e-72 241.4 20.8 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0014) Phage_holin_5_2 PF16079.5 ADV24328.1 - 0.37 11.1 0.0 0.37 11.1 0.0 3.7 3 2 1 4 4 4 0 Phage holin family Hol44, in holin superfamily V Galactosyl_T PF01762.21 ADV24329.1 - 3.6e-07 30.2 1.0 6.6e-05 22.8 0.1 3.0 2 1 1 3 3 3 3 Galactosyltransferase MFS_1 PF07690.16 ADV24330.1 - 2.6e-32 112.1 29.3 4e-32 111.5 29.3 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily RPAP1_N PF08621.10 ADV24330.1 - 0.025 14.4 1.3 0.057 13.2 0.1 2.2 2 0 0 2 2 2 0 RPAP1-like, N-terminal Sugar_tr PF00083.24 ADV24330.1 - 0.098 11.5 20.6 0.55 9.0 17.5 3.0 1 1 1 2 2 2 0 Sugar (and other) transporter Amidase PF01425.21 ADV24331.1 - 1.8e-102 343.6 0.3 2.3e-102 343.3 0.3 1.0 1 0 0 1 1 1 1 Amidase PS_Dcarbxylase PF02666.15 ADV24332.1 - 1.9e-52 177.8 0.0 2.7e-52 177.2 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase Peptidase_M48_N PF16491.5 ADV24333.1 - 6.2e-56 189.2 1.9 1.3e-55 188.1 1.9 1.6 1 0 0 1 1 1 1 CAAX prenyl protease N-terminal, five membrane helices Peptidase_M48 PF01435.18 ADV24333.1 - 3.9e-46 157.3 0.0 5.7e-46 156.8 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M48 UCH_1 PF13423.6 ADV24334.1 - 4.2e-88 296.0 0.0 5.5e-88 295.6 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RNase_T PF00929.24 ADV24334.1 - 1.8e-18 67.6 0.0 2.9e-18 67.0 0.0 1.3 1 0 0 1 1 1 1 Exonuclease UCH PF00443.29 ADV24334.1 - 0.00097 18.7 0.0 0.0022 17.5 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-BED PF02892.15 ADV24334.1 - 0.14 12.2 2.2 0.14 12.2 0.3 1.9 2 0 0 2 2 2 0 BED zinc finger NST1 PF13945.6 ADV24335.1 - 2.7e-39 135.3 0.0 2.7e-39 135.3 0.0 6.6 6 1 1 7 7 7 3 Salt tolerance down-regulator Ribosomal_L18A PF01775.17 ADV24336.1 - 2.8e-54 182.4 0.7 3.5e-54 182.1 0.7 1.1 1 0 0 1 1 1 1 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A DEAD PF00270.29 ADV24337.1 - 1.6e-35 122.5 0.0 2.8e-35 121.7 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ADV24337.1 - 5.8e-18 65.3 0.0 1.9e-16 60.3 0.0 2.6 2 1 0 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 ADV24337.1 - 7.4e-17 61.3 0.6 1.6e-16 60.3 0.6 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 ADV24337.1 - 2.2e-05 24.5 0.0 4.9e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF4611 PF15387.6 ADV24337.1 - 0.041 14.1 7.2 0.43 10.8 0.2 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4611) Myc_N PF01056.18 ADV24337.1 - 0.14 12.1 3.3 5.2 6.9 0.3 2.4 2 0 0 2 2 2 0 Myc amino-terminal region TLP-20 PF06088.11 ADV24337.1 - 8.4 6.3 7.9 18 5.2 1.6 2.8 3 0 0 3 3 3 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) Git3 PF11710.8 ADV24338.1 - 1e-07 32.0 12.3 1e-07 32.0 12.3 1.5 2 0 0 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 7tm_1 PF00001.21 ADV24338.1 - 3.3e-07 29.9 0.0 6.2e-07 29.0 0.0 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Dicty_CAR PF05462.11 ADV24338.1 - 0.045 12.9 10.8 0.07 12.3 10.8 1.2 1 0 0 1 1 1 0 Slime mold cyclic AMP receptor DUF373 PF04123.13 ADV24338.1 - 7.7 5.9 11.4 12 5.2 11.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF373) NUDIX PF00293.28 ADV24339.1 - 1.2e-07 31.8 0.0 1.7e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain Methyltransf_33 PF10017.9 ADV24341.1 - 4.6e-58 196.8 0.0 3e-34 118.6 0.0 3.0 2 1 0 2 2 2 2 Histidine-specific methyltransferase, SAM-dependent FGE-sulfatase PF03781.16 ADV24341.1 - 1.1e-20 74.4 0.5 9e-20 71.3 0.5 2.2 1 1 0 1 1 1 1 Sulfatase-modifying factor enzyme 1 DinB_2 PF12867.7 ADV24341.1 - 1.9e-06 28.4 1.1 4.5e-06 27.2 1.1 1.6 1 0 0 1 1 1 1 DinB superfamily CHCH PF06747.13 ADV24342.1 - 1.6e-07 31.3 5.4 2.1e-07 30.9 5.4 1.2 1 0 0 1 1 1 1 CHCH domain NDUF_B7 PF05676.13 ADV24342.1 - 0.0027 17.4 0.4 0.0033 17.1 0.4 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) CX9C PF16860.5 ADV24342.1 - 0.0063 16.5 1.7 0.01 15.8 1.7 1.3 1 0 0 1 1 1 1 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Pet191_N PF10203.9 ADV24342.1 - 0.28 11.5 4.2 0.74 10.2 4.2 1.6 1 1 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 COX17 PF05051.13 ADV24342.1 - 0.43 11.0 3.5 2.4 8.6 0.4 2.1 1 1 1 2 2 2 0 Cytochrome C oxidase copper chaperone (COX17) DDOST_48kD PF03345.14 ADV24343.1 - 9.3e-139 462.8 0.0 1.1e-138 462.6 0.0 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta AstA PF04958.12 ADV24343.1 - 0.015 13.9 0.0 0.024 13.2 0.0 1.2 1 0 0 1 1 1 0 Arginine N-succinyltransferase beta subunit NCA2 PF08637.10 ADV24344.1 - 3.8e-77 259.3 0.0 6.7e-77 258.5 0.0 1.4 1 0 0 1 1 1 1 ATP synthase regulation protein NCA2 T3SchapCesA PF11439.8 ADV24344.1 - 0.22 11.7 0.4 11 6.2 0.1 2.8 3 0 0 3 3 3 0 Type III secretion system filament chaperone CesA Rab5ip PF07019.12 ADV24345.1 - 0.52 10.9 7.6 0.93 10.1 1.7 2.8 2 0 0 2 2 2 0 Rab5-interacting protein (Rab5ip) Phosphonate-bd PF12974.7 ADV24346.1 - 0.00061 19.5 0.0 0.0026 17.4 0.0 1.8 1 1 0 1 1 1 1 ABC transporter, phosphonate, periplasmic substrate-binding protein SGL PF08450.12 ADV24348.1 - 2.8e-24 86.0 0.2 5.7e-24 85.1 0.2 1.6 1 1 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Str_synth PF03088.16 ADV24348.1 - 3.5e-09 36.7 0.0 1.5e-08 34.7 0.0 2.0 1 1 0 1 1 1 1 Strictosidine synthase NHL PF01436.21 ADV24348.1 - 2.1e-06 27.5 0.3 0.045 13.8 0.0 3.3 3 0 0 3 3 3 2 NHL repeat Arylesterase PF01731.20 ADV24348.1 - 3.4e-06 27.1 0.1 0.0003 20.9 0.0 3.4 3 1 1 4 4 4 1 Arylesterase STT3_PglB_C PF18527.1 ADV24348.1 - 0.16 12.1 0.0 0.35 11.0 0.0 1.5 1 0 0 1 1 1 0 STT3/PglB C-terminal beta-barrel domain Pkinase PF00069.25 ADV24349.1 - 3.4e-64 216.8 0.2 5.7e-64 216.0 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV24349.1 - 4e-45 154.1 0.9 1.7e-44 152.0 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 ADV24349.1 - 1.5e-06 27.7 0.0 6.9e-05 22.3 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Ras_bdg_2 PF14847.6 ADV24349.1 - 0.0012 19.2 0.0 0.0038 17.5 0.0 1.8 2 0 0 2 2 2 1 Ras-binding domain of Byr2 MiaE_2 PF13794.6 ADV24349.1 - 0.25 11.0 2.5 4.2 7.0 2.7 2.2 2 0 0 2 2 2 0 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like PCEMA1 PF07418.11 ADV24349.1 - 0.62 9.5 8.6 1.1 8.7 8.6 1.3 1 0 0 1 1 1 0 Acidic phosphoprotein precursor PCEMA1 Cauli_VI PF01693.16 ADV24350.1 - 9.7e-10 38.6 0.0 1.7e-09 37.9 0.0 1.4 1 0 0 1 1 1 1 Caulimovirus viroplasmin 4HBT PF03061.22 ADV24351.1 - 4.6e-11 42.9 0.0 8.3e-11 42.1 0.0 1.4 1 0 0 1 1 1 1 Thioesterase superfamily DUF3602 PF12223.8 ADV24352.1 - 2.8e-26 91.9 37.6 1.5e-06 28.7 5.8 6.2 1 1 4 6 6 6 6 Protein of unknown function (DUF3602) SDP_N PF12278.8 ADV24352.1 - 0.89 9.7 5.3 0.91 9.7 2.8 2.2 2 1 0 2 2 2 0 Sex determination protein N terminal PMT PF02366.18 ADV24353.1 - 4.9e-80 268.6 16.6 4.9e-80 268.6 16.6 2.4 3 0 0 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 ADV24353.1 - 4.4e-54 183.1 20.3 4.4e-54 183.1 20.3 2.1 2 1 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 ADV24353.1 - 1.2e-25 90.5 0.1 1.9e-25 89.8 0.1 1.2 1 0 0 1 1 1 1 MIR domain P21-Arc PF04062.14 ADV24354.1 - 3.2e-71 238.9 0.0 3.8e-71 238.7 0.0 1.1 1 0 0 1 1 1 1 ARP2/3 complex ARPC3 (21 kDa) subunit CRCB PF02537.15 ADV24355.1 - 4.4e-29 100.7 15.4 3e-18 65.9 2.7 2.3 2 0 0 2 2 2 2 CrcB-like protein, Camphor Resistance (CrcB) RRM_1 PF00076.22 ADV24356.1 - 1.5e-12 47.2 0.0 1.7e-10 40.6 0.0 2.6 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Keratin_2_tail PF16210.5 ADV24356.1 - 0.098 12.9 2.3 0.16 12.3 2.3 1.2 1 0 0 1 1 1 0 Keratin type II cytoskeletal 1 tail RRM_5 PF13893.6 ADV24356.1 - 0.12 12.0 0.0 13 5.4 0.0 2.2 1 1 1 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Fungal_trans PF04082.18 ADV24358.1 - 3.2e-11 42.8 0.0 5.4e-11 42.0 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ADV24358.1 - 1.7e-05 24.8 8.8 2.8e-05 24.2 8.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Homoserine_dh PF00742.19 ADV24359.1 - 3.3e-50 170.4 0.0 4.3e-50 170.0 0.0 1.1 1 0 0 1 1 1 1 Homoserine dehydrogenase NAD_binding_3 PF03447.16 ADV24359.1 - 4.9e-15 56.2 0.0 1.1e-14 55.1 0.0 1.6 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain Iso_dh PF00180.20 ADV24360.1 - 6.4e-77 259.0 0.0 7.4e-77 258.8 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase TBPIP PF07106.13 ADV24360.1 - 0.096 12.6 0.1 2.7 8.0 0.0 3.2 3 0 0 3 3 3 0 TBPIP/Hop2 winged helix domain FYVE PF01363.21 ADV24361.1 - 3.7e-23 81.5 0.3 6.3e-23 80.7 0.3 1.4 1 0 0 1 1 1 1 FYVE zinc finger Rbsn PF11464.8 ADV24361.1 - 3.1e-13 49.2 1.2 3.1e-13 49.2 1.2 2.0 2 0 0 2 2 2 1 Rabenosyn Rab binding domain DUF3395 PF11875.8 ADV24361.1 - 0.093 12.6 0.5 0.23 11.3 0.5 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3395) Allexi_40kDa PF05549.11 ADV24361.1 - 0.62 9.5 3.2 0.3 10.5 0.7 1.7 2 0 0 2 2 2 0 Allexivirus 40kDa protein FAM184 PF15665.5 ADV24361.1 - 7.8 6.2 10.1 0.35 10.6 3.3 1.9 2 0 0 2 2 2 0 Family with sequence similarity 184, A and B KDZ PF18758.1 ADV24362.1 - 1.1e-06 28.4 0.1 1.2e-06 28.4 0.1 1.0 1 0 0 1 1 1 1 Kyakuja-Dileera-Zisupton transposase Methyltransf_23 PF13489.6 ADV24363.1 - 6.7e-15 55.3 0.0 1.1e-14 54.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ADV24363.1 - 2.8e-13 50.4 0.0 1.8e-12 47.9 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ADV24363.1 - 9.2e-11 42.3 0.0 0.00016 22.3 0.0 2.4 1 1 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 ADV24363.1 - 3.9e-09 37.0 0.0 5.4e-07 30.2 0.0 2.7 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 ADV24363.1 - 1.7e-07 31.2 0.0 2.3e-06 27.5 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 ADV24363.1 - 5.3e-06 25.8 0.0 0.074 12.2 0.0 2.2 2 0 0 2 2 2 2 NNMT/PNMT/TEMT family MTS PF05175.14 ADV24363.1 - 0.00013 21.6 0.0 0.00023 20.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain CheR PF01739.18 ADV24363.1 - 0.0013 18.3 0.0 0.019 14.4 0.0 2.1 1 1 0 1 1 1 1 CheR methyltransferase, SAM binding domain Methyltransf_32 PF13679.6 ADV24363.1 - 0.041 13.9 0.0 0.065 13.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Pox_MCEL PF03291.16 ADV24363.1 - 0.15 11.1 0.0 0.29 10.2 0.0 1.5 1 1 0 1 1 1 0 mRNA capping enzyme CHS5_N PF16892.5 ADV24363.1 - 0.28 11.2 0.6 1.2 9.2 0.4 1.9 2 0 0 2 2 2 0 Chitin biosynthesis protein CHS5 N-terminus Oxidored-like PF09791.9 ADV24364.1 - 1.4e-19 69.5 2.5 2.5e-19 68.6 2.5 1.5 1 0 0 1 1 1 1 Oxidoreductase-like protein, N-terminal Ras PF00071.22 ADV24365.1 - 1.7e-55 187.1 0.1 1.9e-55 186.9 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ADV24365.1 - 3.2e-34 117.7 0.0 4.6e-34 117.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ADV24365.1 - 1.6e-13 50.5 0.0 1.8e-13 50.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ADV24365.1 - 3.9e-07 30.1 0.0 5.2e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ADV24365.1 - 4.3e-07 30.0 0.3 0.0031 17.5 0.0 2.1 1 1 0 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 ADV24365.1 - 2.7e-05 23.6 0.0 3.5e-05 23.3 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 ADV24365.1 - 0.00026 20.6 0.0 0.00065 19.3 0.0 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 ADV24365.1 - 0.0044 16.5 0.1 0.0076 15.7 0.1 1.4 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit NTPase_1 PF03266.15 ADV24365.1 - 0.017 15.0 0.0 0.023 14.6 0.0 1.2 1 0 0 1 1 1 0 NTPase AAA_16 PF13191.6 ADV24365.1 - 0.03 14.7 0.1 0.056 13.8 0.1 1.7 1 1 0 1 1 1 0 AAA ATPase domain G-alpha PF00503.20 ADV24365.1 - 0.046 12.9 0.1 0.98 8.5 0.0 2.1 1 1 1 2 2 2 0 G-protein alpha subunit ATPase_2 PF01637.18 ADV24365.1 - 0.071 13.0 0.2 0.14 12.0 0.2 1.6 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea TniB PF05621.11 ADV24365.1 - 0.15 11.4 0.0 0.36 10.2 0.0 1.6 2 0 0 2 2 2 0 Bacterial TniB protein EMG1 PF03587.14 ADV24366.1 - 9.4e-78 260.3 0.0 1.2e-77 260.0 0.0 1.1 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase XPG_I_2 PF12813.7 ADV24367.1 - 8.2e-05 22.2 0.0 0.00023 20.7 0.0 1.8 2 0 0 2 2 2 1 XPG domain containing XPG_N PF00752.17 ADV24367.1 - 0.01 16.3 0.0 0.068 13.7 0.0 2.1 2 0 0 2 2 2 0 XPG N-terminal domain Fungal_trans PF04082.18 ADV24368.1 - 2.6e-12 46.3 0.1 5.7e-12 45.2 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ADV24368.1 - 4.8e-08 33.0 13.3 8.6e-08 32.2 13.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DHFR_1 PF00186.19 ADV24369.1 - 9.6e-26 90.4 0.0 2.5e-23 82.6 0.0 2.5 2 1 0 2 2 2 2 Dihydrofolate reductase Ribosomal_L4 PF00573.22 ADV24370.1 - 1e-41 142.8 0.6 1.9e-41 141.9 0.6 1.4 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.6 ADV24370.1 - 1.2e-31 108.6 1.7 2.3e-30 104.5 0.6 2.4 2 0 0 2 2 2 1 60S ribosomal protein L4 C-terminal domain Ras PF00071.22 ADV24371.1 - 2.3e-50 170.3 0.1 1e-32 113.0 0.0 2.0 2 0 0 2 2 2 2 Ras family Roc PF08477.13 ADV24371.1 - 1.4e-15 57.5 0.0 3.4e-14 53.1 0.0 2.2 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ADV24371.1 - 0.00065 19.2 0.1 0.2 11.1 0.0 2.1 2 0 0 2 2 2 2 ADP-ribosylation factor family RsgA_GTPase PF03193.16 ADV24371.1 - 0.00079 19.4 0.0 0.018 15.0 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase FeoB_N PF02421.18 ADV24371.1 - 0.0038 16.8 0.0 0.031 13.8 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B Ammonium_transp PF00909.21 ADV24372.1 - 2.3e-114 382.2 28.3 2.6e-114 382.0 28.3 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family RTX PF02382.15 ADV24372.1 - 0.53 9.9 3.5 0.89 9.2 3.5 1.2 1 0 0 1 1 1 0 N-terminal domain in RTX protein CD20 PF04103.15 ADV24373.1 - 0.63 10.1 8.3 1.2 9.3 8.3 1.5 1 1 0 1 1 1 0 CD20-like family Tetraspanin PF00335.20 ADV24373.1 - 1 9.0 9.8 0.47 10.1 7.4 1.6 1 1 0 1 1 1 0 Tetraspanin family Pyridox_oxase_2 PF12766.7 ADV24374.1 - 9.2e-19 67.9 0.0 1.3e-18 67.4 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Putative_PNPOx PF01243.20 ADV24374.1 - 0.0098 16.1 0.0 0.023 14.9 0.0 1.6 1 1 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Duffy_binding PF05424.11 ADV24374.1 - 0.043 13.9 0.1 0.059 13.4 0.1 1.2 1 0 0 1 1 1 0 Duffy binding domain PRKCSH PF07915.13 ADV24375.1 - 6.8e-16 59.0 0.1 2.2e-15 57.4 0.0 2.0 2 0 0 2 2 2 1 Glucosidase II beta subunit-like protein PRKCSH_1 PF13015.6 ADV24375.1 - 0.00073 19.3 0.1 0.21 11.3 0.1 2.3 2 0 0 2 2 2 2 Glucosidase II beta subunit-like protein GLE1 PF07817.13 ADV24376.1 - 2.4e-66 223.5 0.1 1.6e-65 220.8 0.0 2.0 2 0 0 2 2 2 1 GLE1-like protein PMI_typeI PF01238.21 ADV24377.1 - 1.2e-62 212.3 0.0 1.8e-62 211.7 0.0 1.2 1 0 0 1 1 1 1 Phosphomannose isomerase type I DNA_primase_lrg PF04104.14 ADV24378.1 - 1.6e-91 306.4 0.0 2.6e-91 305.7 0.0 1.4 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit SPRY PF00622.28 ADV24379.1 - 5.4e-21 74.9 0.0 8.7e-21 74.3 0.0 1.3 1 0 0 1 1 1 1 SPRY domain TMEM154 PF15102.6 ADV24379.1 - 0.44 10.5 0.0 0.44 10.5 0.0 2.4 3 0 0 3 3 3 0 TMEM154 protein family DDE_1 PF03184.19 ADV24381.1 - 8.9e-18 64.5 0.0 1.7e-17 63.7 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 ADV24381.1 - 0.019 14.7 0.0 0.049 13.4 0.0 1.6 1 0 0 1 1 1 0 DDE superfamily endonuclease CH PF00307.31 ADV24382.1 - 2.2e-80 266.0 0.0 8.4e-20 71.0 0.0 4.2 4 0 0 4 4 4 4 Calponin homology (CH) domain EF-hand_7 PF13499.6 ADV24382.1 - 3e-05 24.4 0.2 0.00012 22.4 0.2 2.1 1 0 0 1 1 1 1 EF-hand domain pair CAMSAP_CH PF11971.8 ADV24382.1 - 4.2e-05 23.3 0.0 2.8 7.8 0.0 3.9 4 0 0 4 4 4 3 CAMSAP CH domain EF-hand_6 PF13405.6 ADV24382.1 - 0.0035 17.2 0.3 0.03 14.2 0.1 2.7 3 0 0 3 3 3 1 EF-hand domain Peptidase_M36 PF02128.15 ADV24383.1 - 5.7e-152 506.2 0.0 7.1e-152 505.9 0.0 1.1 1 0 0 1 1 1 1 Fungalysin metallopeptidase (M36) FTP PF07504.13 ADV24383.1 - 1e-12 47.6 0.1 2.1e-12 46.7 0.1 1.5 1 0 0 1 1 1 1 Fungalysin/Thermolysin Propeptide Motif Peptidase_M4_C PF02868.15 ADV24383.1 - 0.05 13.5 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 Thermolysin metallopeptidase, alpha-helical domain MitMem_reg PF13012.6 ADV24383.1 - 0.14 12.6 0.0 0.28 11.6 0.0 1.4 1 0 0 1 1 1 0 Maintenance of mitochondrial structure and function Flavodoxin_3 PF12641.7 ADV24383.1 - 0.14 11.8 0.0 0.31 10.7 0.0 1.6 1 0 0 1 1 1 0 Flavodoxin domain Mito_carr PF00153.27 ADV24384.1 - 6.3e-55 183.1 0.2 1.1e-18 66.9 0.0 3.3 3 1 0 3 3 3 3 Mitochondrial carrier protein SNF2_N PF00176.23 ADV24385.1 - 2e-65 220.8 0.0 3.1e-65 220.2 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ADV24385.1 - 3.7e-14 53.0 0.0 9.3e-14 51.7 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-RING_5 PF14634.6 ADV24385.1 - 0.016 15.1 3.6 0.048 13.6 3.6 1.9 1 0 0 1 1 1 0 zinc-RING finger domain PDDEXK_5 PF11645.8 ADV24385.1 - 0.019 14.9 0.2 0.069 13.1 0.0 2.0 2 0 0 2 2 2 0 PD-(D/E)XK endonuclease HIRAN PF08797.11 ADV24385.1 - 0.11 12.5 0.0 0.29 11.1 0.0 1.7 1 0 0 1 1 1 0 HIRAN domain NUDIX PF00293.28 ADV24386.1 - 2.2e-13 50.4 0.0 4e-13 49.6 0.0 1.5 1 1 0 1 1 1 1 NUDIX domain RNA_pol_Rbc25 PF08292.12 ADV24387.1 - 1.6e-27 96.3 0.0 2.1e-27 95.9 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.17 ADV24387.1 - 2.9e-08 34.0 0.0 7e-08 32.7 0.0 1.6 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 LRR_8 PF13855.6 ADV24388.1 - 0.00043 20.0 0.1 0.0012 18.6 0.1 1.7 1 1 0 1 1 1 1 Leucine rich repeat LRR_4 PF12799.7 ADV24388.1 - 0.00075 19.8 0.1 0.0025 18.2 0.1 1.9 1 0 0 1 1 1 1 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ADV24388.1 - 0.021 15.3 0.4 1.4 9.7 0.0 3.3 2 0 0 2 2 2 0 Leucine Rich Repeat DUF16 PF01519.16 ADV24389.1 - 0.0092 16.5 5.1 0.0092 16.5 5.1 2.7 3 0 0 3 3 2 1 Protein of unknown function DUF16 GAS PF13851.6 ADV24389.1 - 0.061 12.7 30.9 0.047 13.0 18.7 2.4 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding APG6_N PF17675.1 ADV24389.1 - 0.071 13.6 37.3 0.91 10.1 16.7 2.5 1 1 1 2 2 2 0 Apg6 coiled-coil region Surfac_D-trimer PF09006.11 ADV24389.1 - 0.085 12.8 0.0 0.33 10.9 0.0 2.0 1 0 0 1 1 1 0 Lung surfactant protein D coiled-coil trimerisation SNAD2 PF18745.1 ADV24389.1 - 0.3 10.8 2.3 0.63 9.7 2.3 1.5 1 0 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 2 CALCOCO1 PF07888.11 ADV24389.1 - 0.54 9.1 32.1 21 3.8 18.9 2.0 1 1 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like MAD PF05557.13 ADV24389.1 - 0.61 8.4 33.3 3.2 6.0 33.3 1.8 1 1 0 1 1 1 0 Mitotic checkpoint protein YkyA PF10368.9 ADV24389.1 - 0.84 9.3 15.6 1.5 8.5 15.6 1.3 1 0 0 1 1 1 0 Putative cell-wall binding lipoprotein HAP1_N PF04849.13 ADV24389.1 - 1.5 7.9 32.2 0.34 10.1 23.9 2.2 1 1 1 2 2 2 0 HAP1 N-terminal conserved region TMF_DNA_bd PF12329.8 ADV24389.1 - 2.6 8.1 25.4 0.49 10.4 6.7 3.2 2 2 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF1192 PF06698.11 ADV24389.1 - 3.1 7.9 12.7 2.3 8.3 2.6 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) KLRAQ PF10205.9 ADV24389.1 - 4.4 7.6 22.6 2.5 8.4 7.6 2.7 3 0 0 3 3 2 0 Predicted coiled-coil domain-containing protein Herpes_BLRF2 PF05812.12 ADV24389.1 - 4.7 7.4 13.1 2.7 8.2 2.2 3.1 2 0 0 2 2 2 0 Herpesvirus BLRF2 protein HIP1_clath_bdg PF16515.5 ADV24389.1 - 6 7.5 30.1 0.08 13.6 9.4 3.0 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Fez1 PF06818.15 ADV24389.1 - 6.2 7.2 31.2 0.16 12.4 21.2 2.5 1 1 1 2 2 2 0 Fez1 Spc7 PF08317.11 ADV24389.1 - 6.3 5.6 31.3 3.7 6.4 13.8 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF641 PF04859.12 ADV24389.1 - 9.1 6.6 21.1 3.2 8.1 6.1 3.0 1 1 2 3 3 3 0 Plant protein of unknown function (DUF641) SH3_1 PF00018.28 ADV24390.1 - 8.3e-34 115.0 4.7 7.2e-18 63.9 0.5 2.4 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.6 ADV24390.1 - 1.9e-32 110.8 2.5 5.3e-16 58.2 0.3 2.4 2 0 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.17 ADV24390.1 - 1.9e-20 72.3 0.0 6.7e-09 35.3 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain Cofilin_ADF PF00241.20 ADV24390.1 - 8.2e-16 57.9 0.0 1.5e-15 57.1 0.0 1.4 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein DUF2462 PF09495.10 ADV24391.1 - 2.2e-15 57.2 11.2 2.2e-15 57.2 11.2 1.3 2 0 0 2 2 2 1 Protein of unknown function (DUF2462) Astro_capsid_N PF03115.14 ADV24391.1 - 1.4 7.5 5.8 1.6 7.3 5.8 1.0 1 0 0 1 1 1 0 Astrovirus capsid protein precursor RNase_PH PF01138.21 ADV24392.1 - 1.6e-16 61.0 0.0 3.1e-16 60.1 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 ADV24392.1 - 0.023 14.7 0.0 0.062 13.3 0.0 1.7 1 1 0 1 1 1 0 3' exoribonuclease family, domain 2 Mago-bind PF09282.10 ADV24392.1 - 1.3 8.9 3.3 76 3.3 0.0 3.1 3 0 0 3 3 3 0 Mago binding PIG-P PF08510.12 ADV24393.1 - 1.3e-09 38.0 11.4 1.6e-09 37.7 11.4 1.1 1 0 0 1 1 1 1 PIG-P DPM2 PF07297.12 ADV24393.1 - 0.027 14.7 8.2 0.046 14.0 8.2 1.3 1 1 0 1 1 1 0 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) Cep57_MT_bd PF06657.13 ADV24394.1 - 1.8e-16 60.3 3.8 1.8e-16 60.3 3.8 4.3 2 1 3 5 5 5 1 Centrosome microtubule-binding domain of Cep57 Fib_alpha PF08702.10 ADV24394.1 - 0.002 18.4 1.2 0.002 18.4 1.2 3.8 4 1 0 4 4 4 1 Fibrinogen alpha/beta chain family IFT57 PF10498.9 ADV24394.1 - 0.0047 16.0 5.0 0.0047 16.0 5.0 3.6 1 1 3 4 4 4 1 Intra-flagellar transport protein 57 Spc7 PF08317.11 ADV24394.1 - 0.11 11.3 26.8 0.0087 15.0 7.8 3.3 2 1 1 3 3 3 0 Spc7 kinetochore protein Mating_N PF12731.7 ADV24394.1 - 0.19 11.8 1.6 0.62 10.2 1.6 1.9 1 0 0 1 1 1 0 Mating-type protein beta 1 DUF1664 PF07889.12 ADV24394.1 - 0.24 11.5 10.6 0.091 12.8 0.8 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) DUF2746 PF10874.8 ADV24394.1 - 0.3 11.5 1.0 14 6.2 0.0 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF2746) DUF948 PF06103.11 ADV24394.1 - 0.56 10.5 5.4 0.61 10.4 0.7 3.1 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Med30 PF11315.8 ADV24394.1 - 0.75 10.0 7.6 0.2 11.9 0.8 3.0 2 0 0 2 2 2 0 Mediator complex subunit 30 Actino_peptide PF14408.6 ADV24394.1 - 1.2 9.2 4.8 1.9 8.7 0.0 3.2 3 0 0 3 3 3 0 Ribosomally synthesised peptide in actinomycetes FlaC_arch PF05377.11 ADV24394.1 - 1.6 9.2 8.9 3.8 8.0 0.8 3.5 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) SLATT_fungal PF18142.1 ADV24394.1 - 1.9 8.5 4.4 2.6 8.1 1.0 2.8 1 1 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain BLOC1_2 PF10046.9 ADV24394.1 - 1.9 8.8 15.3 11 6.3 0.2 3.7 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Syntaxin-6_N PF09177.11 ADV24394.1 - 3.6 8.2 16.7 0.33 11.5 4.6 3.8 3 2 1 4 4 4 0 Syntaxin 6, N-terminal CDC37_N PF03234.14 ADV24395.1 - 8.7e-40 136.6 0.7 8.7e-40 136.6 0.7 2.4 2 0 0 2 2 2 1 Cdc37 N terminal kinase binding CDC37_M PF08565.11 ADV24395.1 - 2.2e-33 114.7 0.1 4.3e-33 113.7 0.1 1.5 1 0 0 1 1 1 1 Cdc37 Hsp90 binding domain CDC37_C PF08564.10 ADV24395.1 - 5.6e-21 74.5 0.1 5.6e-21 74.5 0.1 2.1 2 0 0 2 2 2 1 Cdc37 C terminal domain SAGA-Tad1 PF12767.7 ADV24395.1 - 0.24 11.1 2.3 0.34 10.6 1.9 1.5 1 1 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit Bromo_TP PF07524.13 ADV24396.1 - 2.1e-05 24.4 0.0 3.4e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Bromodomain associated TFIID-31kDa PF02291.15 ADV24396.1 - 0.0061 16.6 0.0 0.012 15.7 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit CENP-T_C PF15511.6 ADV24396.1 - 0.084 13.0 0.0 0.15 12.2 0.0 1.6 1 1 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold Sugar_tr PF00083.24 ADV24397.1 - 7.8e-94 315.1 23.5 9.5e-94 314.8 23.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ADV24397.1 - 2.1e-25 89.4 29.8 6.1e-19 68.2 5.3 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 ADV24397.1 - 7.4e-06 24.5 4.1 0.00057 18.3 0.0 2.7 1 1 0 2 2 2 2 Organic Anion Transporter Polypeptide (OATP) family Phage_holin_3_2 PF04550.12 ADV24397.1 - 0.02 15.4 2.2 0.02 15.4 2.2 3.0 3 1 0 3 3 3 0 Phage holin family 2 DUF2530 PF10745.9 ADV24397.1 - 0.03 14.5 2.6 0.03 14.5 2.6 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2530) Sugar_tr PF00083.24 ADV24398.1 - 8.6e-89 298.4 23.0 1e-88 298.2 23.0 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ADV24398.1 - 4.2e-21 75.3 34.8 1.5e-19 70.1 31.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Phage_holin_3_2 PF04550.12 ADV24398.1 - 0.091 13.3 1.6 0.32 11.6 1.6 2.0 1 0 0 1 1 1 0 Phage holin family 2 PilX_N PF14341.6 ADV24398.1 - 4.1 7.4 6.7 33 4.5 0.2 2.9 2 0 0 2 2 2 0 PilX N-terminal DUF2530 PF10745.9 ADV24398.1 - 8.2 6.8 10.9 0.41 10.9 3.3 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF2530) MFS_1 PF07690.16 ADV24402.1 - 4.7e-43 147.5 31.4 4.7e-43 147.5 31.4 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 ADV24402.1 - 1.1e-06 27.4 2.5 1.1e-06 27.4 2.5 1.4 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) UNC-93 PF05978.16 ADV24402.1 - 0.0066 16.2 0.6 0.0066 16.2 0.6 3.3 4 0 0 4 4 4 1 Ion channel regulatory protein UNC-93 Mito_carr PF00153.27 ADV24403.1 - 1.2e-48 163.0 0.0 5.2e-17 61.6 0.0 3.8 3 2 0 3 3 3 3 Mitochondrial carrier protein SRP19 PF01922.17 ADV24404.1 - 4.9e-29 101.1 0.0 9.6e-29 100.2 0.0 1.5 1 0 0 1 1 1 1 SRP19 protein Ribosomal_L14e PF01929.17 ADV24405.1 - 8.5e-31 106.3 0.1 1.4e-30 105.6 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L14 KOW PF00467.29 ADV24405.1 - 2.1e-06 27.5 0.2 3.5e-06 26.8 0.2 1.4 1 0 0 1 1 1 1 KOW motif tRNA-synt_2d PF01409.20 ADV24406.1 - 3.1e-89 298.7 0.1 4.8e-89 298.1 0.1 1.2 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) PheRS_DBD3 PF18553.1 ADV24406.1 - 5.4e-14 52.2 0.5 2.7e-13 50.0 0.1 2.3 2 0 0 2 2 2 1 PheRS DNA binding domain 3 tRNA_synthFbeta PF17759.1 ADV24406.1 - 1.1e-05 25.0 0.0 0.00021 20.8 0.0 2.5 2 1 0 2 2 2 1 Phenylalanyl tRNA synthetase beta chain CLM domain tRNA-synt_2 PF00152.20 ADV24406.1 - 0.0013 17.9 1.0 0.008 15.3 0.0 2.4 3 0 0 3 3 3 1 tRNA synthetases class II (D, K and N) Rio2_N PF09202.11 ADV24406.1 - 0.12 12.6 0.2 9 6.6 0.0 2.4 2 0 0 2 2 2 0 Rio2, N-terminal HTH_45 PF14947.6 ADV24406.1 - 0.14 12.1 0.5 1.6 8.7 0.1 2.3 2 0 0 2 2 2 0 Winged helix-turn-helix DUF563 PF04577.14 ADV24407.1 - 7.3e-13 49.1 0.0 1.1e-12 48.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF563) WD40 PF00400.32 ADV24408.1 - 0.0059 17.4 5.8 0.18 12.7 0.2 4.8 5 0 0 5 5 5 1 WD domain, G-beta repeat Prp18 PF02840.15 ADV24408.1 - 0.0098 15.9 0.1 0.065 13.3 0.0 2.3 2 0 0 2 2 2 1 Prp18 domain Sec16_C PF12931.7 ADV24408.1 - 0.047 13.3 1.0 0.091 12.4 0.0 2.0 2 0 0 2 2 2 0 Sec23-binding domain of Sec16 GPP34 PF05719.11 ADV24409.1 - 9.9e-70 234.7 1.2 1.2e-69 234.4 1.2 1.1 1 0 0 1 1 1 1 Golgi phosphoprotein 3 (GPP34) ProSAAS PF07259.12 ADV24409.1 - 0.24 11.3 3.0 0.44 10.5 0.2 2.2 1 1 1 2 2 2 0 ProSAAS precursor DUF2205 PF10224.9 ADV24410.1 - 1.9e-10 40.6 0.1 2.2e-10 40.4 0.1 1.1 1 0 0 1 1 1 1 Short coiled-coil protein ATG16 PF08614.11 ADV24410.1 - 0.006 16.8 0.4 0.0079 16.4 0.4 1.1 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) YabA PF06156.13 ADV24410.1 - 0.071 13.7 0.2 0.086 13.5 0.2 1.1 1 0 0 1 1 1 0 Initiation control protein YabA Miff PF05644.11 ADV24410.1 - 0.078 12.6 0.0 0.081 12.5 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial and peroxisomal fission factor Mff ATP-synt_C PF00137.21 ADV24412.1 - 3e-27 94.7 28.2 4.2e-15 55.8 11.7 2.5 2 0 0 2 2 2 2 ATP synthase subunit C SLATT_5 PF18160.1 ADV24412.1 - 0.24 10.7 0.4 0.61 9.4 0.0 1.8 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 Oxidored_q2 PF00420.24 ADV24412.1 - 0.69 9.6 7.5 0.11 12.1 2.7 2.3 2 1 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L FH2 PF02181.23 ADV24413.1 - 9.3e-66 222.4 0.5 2.1e-65 221.3 0.5 1.5 1 0 0 1 1 1 1 Formin Homology 2 Domain Drf_FH3 PF06367.16 ADV24413.1 - 5.4e-21 75.1 1.6 1.7e-20 73.5 1.6 1.8 1 0 0 1 1 1 1 Diaphanous FH3 Domain Drf_GBD PF06371.13 ADV24413.1 - 6.6e-20 71.5 0.0 6.6e-19 68.2 0.0 2.4 1 1 1 2 2 2 1 Diaphanous GTPase-binding Domain DUF1477 PF07346.11 ADV24413.1 - 0.078 13.2 0.7 20 5.5 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1477) Rad60-SLD_2 PF13881.6 ADV24414.1 - 4.7e-21 75.0 0.0 5.9e-21 74.7 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 ADV24414.1 - 4.5e-07 29.5 0.1 5.6e-06 26.0 0.1 2.1 1 1 0 1 1 1 1 Ubiquitin family DUF2407 PF10302.9 ADV24414.1 - 0.0021 18.6 0.0 0.0029 18.1 0.0 1.3 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain DnaJ PF00226.31 ADV24415.1 - 4.3e-12 46.0 0.4 2.1e-11 43.8 0.0 2.3 2 0 0 2 2 2 1 DnaJ domain DUF4407 PF14362.6 ADV24415.1 - 1.2 8.4 12.3 0.24 10.7 7.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) CCDC66 PF15236.6 ADV24415.1 - 3.7 7.4 36.5 1 9.2 16.1 2.5 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 66 Pro_isomerase PF00160.21 ADV24416.1 - 1.3e-50 171.8 0.1 1.4e-50 171.6 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TIP41 PF04176.13 ADV24417.1 - 2.8e-51 173.4 0.0 1.2e-50 171.3 0.0 1.8 2 0 0 2 2 2 1 TIP41-like family Med11 PF10280.9 ADV24418.1 - 6.1e-06 26.7 0.0 7.9e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 Mediator complex protein zf-AN1 PF01428.16 ADV24419.1 - 2e-11 43.9 16.3 1.1e-06 28.6 4.2 2.6 2 1 0 2 2 2 2 AN1-like Zinc finger IBR PF01485.21 ADV24419.1 - 0.0027 17.9 1.8 0.0027 17.9 1.8 2.5 2 0 0 2 2 2 1 IBR domain, a half RING-finger domain DSPc PF00782.20 ADV24420.1 - 0.00013 21.8 0.0 0.00022 21.1 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 ADV24420.1 - 0.2 11.6 0.0 0.35 10.8 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family CDKN3 PF05706.12 ADV24420.1 - 0.22 11.2 0.0 0.36 10.5 0.0 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) Y_phosphatase PF00102.27 ADV24420.1 - 0.22 11.1 0.0 0.35 10.4 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase SOG2 PF10428.9 ADV24420.1 - 0.23 10.6 0.2 0.3 10.2 0.2 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein DHDPS PF00701.22 ADV24421.1 - 8.1e-32 110.1 0.0 9.9e-32 109.8 0.0 1.1 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family PA PF02225.22 ADV24421.1 - 0.023 14.7 0.1 0.058 13.4 0.1 1.7 1 0 0 1 1 1 0 PA domain HLH PF00010.26 ADV24423.1 - 1.2e-11 44.4 0.0 2.3e-11 43.4 0.0 1.5 1 1 0 1 1 1 1 Helix-loop-helix DNA-binding domain vATP-synt_E PF01991.18 ADV24423.1 - 0.041 13.3 1.2 0.076 12.4 1.2 1.3 1 0 0 1 1 1 0 ATP synthase (E/31 kDa) subunit SLX9 PF15341.6 ADV24423.1 - 0.6 10.5 6.3 0.26 11.7 2.7 2.0 2 0 0 2 2 2 0 Ribosome biogenesis protein SLX9 DUF4710 PF15828.5 ADV24423.1 - 0.9 9.7 5.0 0.13 12.4 1.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4710) Dppa2_A PF14049.6 ADV24423.1 - 2.5 8.3 5.8 0.38 10.9 1.1 1.9 2 0 0 2 2 2 0 Dppa2/4 conserved region in higher vertebrates FHA PF00498.26 ADV24424.1 - 1.3e-15 57.5 0.1 2.8e-15 56.4 0.1 1.6 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 ADV24424.1 - 0.0066 16.7 0.0 0.02 15.2 0.0 1.9 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain DUF1664 PF07889.12 ADV24424.1 - 0.021 14.9 7.5 0.44 10.6 0.5 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) Baculo_PEP_C PF04513.12 ADV24424.1 - 0.25 11.4 4.3 4.9 7.2 0.6 3.3 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus LSM PF01423.22 ADV24425.1 - 4.2e-17 61.6 0.0 5.2e-17 61.3 0.0 1.1 1 0 0 1 1 1 1 LSM domain Fungal_trans PF04082.18 ADV24426.1 - 2.4e-14 53.0 0.0 3.7e-14 52.4 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ADV24426.1 - 0.0016 18.5 13.3 0.0031 17.6 13.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sds3 PF08598.11 ADV24427.1 - 4 7.4 9.7 0.19 11.7 3.3 1.8 2 1 0 2 2 2 0 Sds3-like Presenilin PF01080.17 ADV24427.1 - 4.5 5.9 6.4 6.8 5.3 6.4 1.2 1 0 0 1 1 1 0 Presenilin ABC1 PF03109.16 ADV24428.1 - 9.1e-30 103.3 0.0 2.4e-29 101.9 0.0 1.7 1 0 0 1 1 1 1 ABC1 family RIO1 PF01163.22 ADV24428.1 - 0.00031 20.4 0.0 0.0028 17.3 0.0 2.1 2 0 0 2 2 2 1 RIO1 family Pkinase PF00069.25 ADV24428.1 - 0.0045 16.4 0.0 0.46 9.8 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain PQ-loop PF04193.14 ADV24429.1 - 2.3e-29 101.0 3.0 1.3e-13 50.5 0.5 2.7 2 0 0 2 2 2 2 PQ loop repeat SAYSvFN PF10260.9 ADV24429.1 - 0.04 13.8 0.2 0.15 12.0 0.1 2.2 2 0 0 2 2 2 0 Uncharacterized conserved domain (SAYSvFN) DHHC PF01529.20 ADV24430.1 - 5.2e-31 107.5 16.1 5.2e-31 107.5 16.1 2.4 2 1 0 2 2 2 1 DHHC palmitoyltransferase HisKA_7TM PF16927.5 ADV24430.1 - 0.033 14.2 7.1 1.6 8.7 0.0 2.1 2 0 0 2 2 2 0 N-terminal 7TM region of histidine kinase Chitin_synth_2 PF03142.15 ADV24430.1 - 0.14 10.8 2.3 0.23 10.0 2.3 1.2 1 0 0 1 1 1 0 Chitin synthase HemY_N PF07219.13 ADV24430.1 - 1 9.6 4.1 1.4 9.1 0.1 2.7 3 0 0 3 3 3 0 HemY protein N-terminus DUF1230 PF06799.11 ADV24430.1 - 1.4 9.0 8.1 1.2 9.2 0.9 2.3 2 0 0 2 2 2 0 Conserved in the green lineage and diatoms 27 LapA_dom PF06305.11 ADV24430.1 - 3.5 7.5 8.2 1.1 9.1 0.2 2.8 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain SHE3 PF17078.5 ADV24431.1 - 0.41 10.3 17.1 0.59 9.8 14.3 2.1 1 1 1 2 2 2 0 SWI5-dependent HO expression protein 3 AAA PF00004.29 ADV24432.1 - 2.4e-96 319.2 0.0 5e-47 159.6 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ADV24432.1 - 2.4e-24 84.9 10.0 1.1e-12 47.6 0.4 3.1 3 0 0 3 3 2 2 AAA+ lid domain CDC48_N PF02359.18 ADV24432.1 - 7.1e-19 67.8 0.2 6.2e-18 64.8 0.2 2.4 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), N-terminal domain RuvB_N PF05496.12 ADV24432.1 - 3.9e-14 52.7 0.1 2.6e-05 24.0 0.0 3.6 3 2 1 4 4 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 ADV24432.1 - 8.5e-13 48.8 0.0 1.4e-06 28.5 0.0 2.8 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 ADV24432.1 - 5.3e-12 46.1 0.0 6.6e-06 26.3 0.0 3.0 3 0 0 3 3 3 2 AAA domain AAA_16 PF13191.6 ADV24432.1 - 2.2e-11 44.4 0.3 0.00071 20.0 0.0 4.2 3 2 0 3 3 2 2 AAA ATPase domain AAA_5 PF07728.14 ADV24432.1 - 2.6e-10 40.4 0.2 0.00013 21.9 0.1 3.7 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) CDC48_2 PF02933.17 ADV24432.1 - 4.6e-10 39.1 0.0 1.2e-09 37.8 0.0 1.7 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 TIP49 PF06068.13 ADV24432.1 - 4.7e-09 35.9 0.1 0.0024 17.1 0.0 2.5 2 1 0 2 2 2 2 TIP49 P-loop domain AAA_22 PF13401.6 ADV24432.1 - 1.3e-08 35.2 0.2 0.043 14.1 0.0 4.0 2 2 1 3 3 2 2 AAA domain Vps4_C PF09336.10 ADV24432.1 - 6.3e-08 32.5 0.3 4.3e-06 26.6 0.0 3.5 4 0 0 4 4 3 1 Vps4 C terminal oligomerisation domain Mg_chelatase PF01078.21 ADV24432.1 - 2.9e-07 30.1 0.3 0.027 13.9 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 ADV24432.1 - 4e-07 30.6 0.0 0.021 15.4 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.6 ADV24432.1 - 5.2e-07 29.4 0.3 0.42 10.1 0.0 3.5 2 1 1 3 3 3 2 AAA domain RNA_helicase PF00910.22 ADV24432.1 - 5.3e-07 30.0 0.0 0.018 15.4 0.0 2.6 2 0 0 2 2 2 2 RNA helicase IstB_IS21 PF01695.17 ADV24432.1 - 7.1e-07 29.1 0.0 0.024 14.4 0.0 2.7 2 0 0 2 2 2 2 IstB-like ATP binding protein Parvo_NS1 PF01057.17 ADV24432.1 - 2.9e-06 26.6 0.1 0.0096 15.0 0.0 2.2 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 AAA_7 PF12775.7 ADV24432.1 - 4.1e-06 26.4 0.0 0.019 14.5 0.0 2.7 2 1 0 2 2 2 2 P-loop containing dynein motor region ATPase PF06745.13 ADV24432.1 - 5.8e-06 25.8 0.3 0.56 9.5 0.0 3.5 3 0 0 3 3 3 2 KaiC AAA_24 PF13479.6 ADV24432.1 - 1e-05 25.4 0.2 0.11 12.2 0.0 2.9 3 1 0 3 3 2 2 AAA domain AAA_14 PF13173.6 ADV24432.1 - 1.4e-05 25.1 0.0 0.098 12.7 0.0 2.6 2 0 0 2 2 2 2 AAA domain DUF815 PF05673.13 ADV24432.1 - 1.6e-05 24.2 0.0 0.018 14.2 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF815) AAA_28 PF13521.6 ADV24432.1 - 1.9e-05 25.0 0.0 0.14 12.4 0.0 2.7 2 0 0 2 2 2 2 AAA domain ABC_tran PF00005.27 ADV24432.1 - 4.2e-05 24.1 0.0 0.087 13.3 0.0 3.5 3 1 0 3 3 2 1 ABC transporter Sigma54_activat PF00158.26 ADV24432.1 - 4.6e-05 23.2 0.0 0.38 10.4 0.0 2.9 2 1 0 2 2 2 2 Sigma-54 interaction domain Bac_DnaA PF00308.18 ADV24432.1 - 8e-05 22.6 0.0 0.57 10.0 0.0 2.9 3 0 0 3 3 3 2 Bacterial dnaA protein AAA_17 PF13207.6 ADV24432.1 - 0.0001 22.7 0.0 0.66 10.4 0.0 3.4 3 0 0 3 3 2 2 AAA domain TsaE PF02367.17 ADV24432.1 - 0.00012 22.1 0.0 0.24 11.4 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE ResIII PF04851.15 ADV24432.1 - 0.00016 21.7 0.2 0.11 12.5 0.0 2.9 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit PhoH PF02562.16 ADV24432.1 - 0.00018 21.1 0.3 0.45 9.9 0.0 2.3 2 0 0 2 2 2 2 PhoH-like protein AAA_3 PF07726.11 ADV24432.1 - 0.00029 20.7 0.0 0.92 9.4 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_11 PF13086.6 ADV24432.1 - 0.00032 20.6 1.8 1.3 8.7 0.0 3.0 2 1 0 2 2 2 2 AAA domain DUF2075 PF09848.9 ADV24432.1 - 0.00034 20.0 2.0 0.47 9.6 0.0 2.9 3 0 0 3 3 3 2 Uncharacterized conserved protein (DUF2075) ATPase_2 PF01637.18 ADV24432.1 - 0.00057 19.9 0.1 4.3 7.2 0.0 3.2 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea Molydop_binding PF01568.21 ADV24432.1 - 0.0008 19.4 0.0 0.0022 18.0 0.0 1.7 1 0 0 1 1 1 1 Molydopterin dinucleotide binding domain NACHT PF05729.12 ADV24432.1 - 0.0014 18.6 0.1 1.1 9.1 0.0 3.2 3 1 0 3 3 3 1 NACHT domain AAA_30 PF13604.6 ADV24432.1 - 0.0018 18.0 0.4 2 8.1 0.0 2.6 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 ADV24432.1 - 0.0028 17.0 0.0 2.4 7.4 0.0 2.8 2 0 0 2 2 2 1 Zeta toxin NB-ARC PF00931.22 ADV24432.1 - 0.0032 16.7 0.0 0.72 9.0 0.0 2.7 3 0 0 3 3 3 1 NB-ARC domain AAA_19 PF13245.6 ADV24432.1 - 0.0048 17.2 1.7 3.5 8.0 0.0 3.4 3 1 0 4 4 2 0 AAA domain Viral_helicase1 PF01443.18 ADV24432.1 - 0.0061 16.3 0.0 0.29 10.9 0.0 2.4 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase Sigma54_activ_2 PF14532.6 ADV24432.1 - 0.018 15.2 0.0 8.8 6.5 0.0 2.7 2 0 0 2 2 2 0 Sigma-54 interaction domain T2SSE PF00437.20 ADV24432.1 - 0.022 13.8 0.0 0.96 8.4 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein Cytidylate_kin PF02224.18 ADV24432.1 - 0.039 13.7 0.0 8.1 6.1 0.0 2.8 2 0 0 2 2 2 0 Cytidylate kinase IPT PF01745.16 ADV24432.1 - 0.046 13.1 0.0 2.3 7.5 0.0 2.2 2 0 0 2 2 2 0 Isopentenyl transferase Zot PF05707.12 ADV24432.1 - 0.058 13.0 0.0 1.7 8.3 0.0 2.5 2 0 0 2 2 2 0 Zonular occludens toxin (Zot) NTPase_1 PF03266.15 ADV24432.1 - 0.062 13.2 0.2 4 7.3 0.0 3.1 3 0 0 3 3 2 0 NTPase UFD1 PF03152.14 ADV24432.1 - 0.083 12.4 0.0 0.17 11.3 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin fusion degradation protein UFD1 RNA_pol_Rpb2_5 PF04567.17 ADV24432.1 - 0.1 13.2 0.2 8.5 7.0 0.1 2.6 2 0 0 2 2 2 0 RNA polymerase Rpb2, domain 5 KAP_NTPase PF07693.14 ADV24432.1 - 0.1 11.8 0.1 1.2 8.3 0.0 2.6 2 2 0 3 3 3 0 KAP family P-loop domain PIF1 PF05970.14 ADV24432.1 - 0.12 11.5 0.0 6.6 5.8 0.0 2.6 2 0 0 2 2 2 0 PIF1-like helicase AAA_6 PF12774.7 ADV24432.1 - 0.26 10.2 0.1 7.6 5.4 0.0 2.2 2 0 0 2 2 2 0 Hydrolytic ATP binding site of dynein motor region Hydin_ADK PF17213.3 ADV24432.1 - 0.48 10.7 3.3 79 3.4 0.0 3.8 4 0 0 4 4 4 0 Hydin Adenylate kinase-like domain DER1 PF04511.15 ADV24433.1 - 1.9e-33 116.0 3.6 2.2e-33 115.8 3.6 1.1 1 0 0 1 1 1 1 Der1-like family Silic_transp PF03842.13 ADV24433.1 - 0.083 11.2 0.8 0.12 10.7 0.8 1.1 1 0 0 1 1 1 0 Silicon transporter PhoR PF11808.8 ADV24433.1 - 7.9 7.0 9.4 1.1 9.7 0.1 2.9 3 0 0 3 3 3 0 Phosphate regulon sensor protein PhoR Promethin PF16015.5 ADV24433.1 - 9.5 6.2 12.8 7 6.6 3.8 2.9 2 1 0 2 2 2 0 Promethin zf-C2H2_4 PF13894.6 ADV24434.1 - 0.8 10.7 4.7 11 7.2 0.4 3.6 2 2 0 2 2 2 0 C2H2-type zinc finger NUDIX PF00293.28 ADV24435.1 - 5.1e-13 49.2 0.0 8.8e-13 48.4 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain RRM_1 PF00076.22 ADV24436.1 - 1.4e-18 66.5 0.0 6.6e-10 38.7 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 ADV24436.1 - 0.00028 20.9 0.0 0.017 15.2 0.0 2.2 2 0 0 2 2 2 1 Limkain b1 RRM_3 PF08777.11 ADV24436.1 - 0.0083 16.2 0.0 0.021 14.8 0.0 1.6 2 0 0 2 2 2 1 RNA binding motif SET_assoc PF11767.8 ADV24436.1 - 0.022 14.4 0.0 0.039 13.6 0.0 1.4 1 0 0 1 1 1 0 Histone lysine methyltransferase SET associated DbpA PF03880.15 ADV24436.1 - 0.084 12.9 0.0 4.3 7.4 0.0 2.2 2 0 0 2 2 2 0 DbpA RNA binding domain LRR_4 PF12799.7 ADV24437.1 - 3.3e-09 36.9 4.9 3.2e-08 33.7 1.9 2.8 1 1 1 2 2 2 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ADV24437.1 - 6.8e-08 32.2 2.9 2e-07 30.7 2.9 1.8 1 1 0 1 1 1 1 Leucine rich repeat LRR_1 PF00560.33 ADV24437.1 - 0.0011 19.2 5.6 0.53 11.0 0.5 4.5 4 0 0 4 4 4 1 Leucine Rich Repeat LRR_6 PF13516.6 ADV24437.1 - 4.1 7.7 8.5 3.3 8.0 0.8 3.3 3 0 0 3 3 3 0 Leucine Rich repeat Mem_trans PF03547.18 ADV24438.1 - 1.5e-28 99.3 5.1 7.3e-28 97.0 5.1 1.9 1 1 0 1 1 1 1 Membrane transport protein BRI3BP PF14965.6 ADV24438.1 - 0.1 12.1 0.4 0.29 10.6 0.4 1.7 1 0 0 1 1 1 0 Negative regulator of p53/TP53 Tom22 PF04281.13 ADV24439.1 - 2e-43 147.5 2.5 2.3e-43 147.3 2.5 1.0 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom22 RNase_PH PF01138.21 ADV24440.1 - 1.8e-28 99.7 0.0 5.2e-28 98.2 0.0 1.7 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 ADV24440.1 - 0.0021 18.0 0.2 0.0042 17.1 0.2 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Fungal_trans PF04082.18 ADV24441.1 - 2.6e-21 75.8 0.5 1.5e-20 73.4 0.0 2.1 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ADV24441.1 - 1.3e-05 25.2 9.2 2.2e-05 24.5 9.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 ADV24442.1 - 6.9e-35 120.6 31.3 6.9e-35 120.6 31.3 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily RhoGAP PF00620.27 ADV24443.1 - 3.1e-43 147.2 0.0 6.4e-43 146.2 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.29 ADV24443.1 - 1.2e-15 57.9 0.0 3.2e-15 56.5 0.0 1.8 1 0 0 1 1 1 1 PH domain PX PF00787.24 ADV24443.1 - 1e-07 31.9 0.0 2.2e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 PX domain PH_8 PF15409.6 ADV24443.1 - 0.019 15.2 0.0 0.068 13.5 0.0 2.0 1 1 0 1 1 1 0 Pleckstrin homology domain Ribosomal_L33 PF00471.20 ADV24444.1 - 1.2e-10 41.6 0.0 1.5e-10 41.3 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L33 Nanovirus_C8 PF05629.11 ADV24444.1 - 0.1 12.7 0.0 0.11 12.6 0.0 1.0 1 0 0 1 1 1 0 Nanovirus component 8 (C8) protein Histone PF00125.24 ADV24445.1 - 2.1e-50 170.5 2.9 2.3e-50 170.3 2.9 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 ADV24445.1 - 2.5e-05 24.6 0.0 3.9e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 ADV24445.1 - 4e-05 23.7 0.5 6.2e-05 23.1 0.1 1.5 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold PAF PF15715.5 ADV24445.1 - 0.00027 21.5 1.2 0.00032 21.3 1.2 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CBFD_NFYB_HMF PF00808.23 ADV24445.1 - 0.014 15.7 0.0 0.025 14.8 0.0 1.4 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone S-methyl_trans PF02574.16 ADV24446.1 - 1.3e-45 156.3 0.0 1.7e-45 155.9 0.0 1.1 1 0 0 1 1 1 1 Homocysteine S-methyltransferase Kelch_1 PF01344.25 ADV24446.1 - 0.13 11.8 0.1 3.7 7.2 0.0 2.9 3 0 0 3 3 3 0 Kelch motif MAD PF05557.13 ADV24447.1 - 2.5e-38 131.9 45.8 4.8e-38 131.0 45.8 1.7 1 1 0 1 1 1 1 Mitotic checkpoint protein Baculo_PEP_C PF04513.12 ADV24447.1 - 1.8e-06 28.1 15.4 0.0068 16.5 0.1 5.1 4 1 1 5 5 5 2 Baculovirus polyhedron envelope protein, PEP, C terminus SPATA24 PF15175.6 ADV24447.1 - 3e-05 24.0 2.3 3e-05 24.0 2.3 3.6 3 1 1 4 4 4 1 Spermatogenesis-associated protein 24 Spc7 PF08317.11 ADV24447.1 - 0.0035 16.3 4.8 0.0035 16.3 4.8 5.6 1 1 6 7 7 7 4 Spc7 kinetochore protein KASH_CCD PF14662.6 ADV24447.1 - 0.0048 16.7 9.4 0.0048 16.7 9.4 5.4 3 2 1 5 5 5 2 Coiled-coil region of CCDC155 or KASH Seryl_tRNA_N PF02403.22 ADV24447.1 - 0.01 16.0 0.8 0.01 16.0 0.8 6.5 4 1 3 7 7 7 0 Seryl-tRNA synthetase N-terminal domain FliJ PF02050.16 ADV24447.1 - 0.14 12.3 0.1 0.14 12.3 0.1 6.6 4 2 2 7 7 6 0 Flagellar FliJ protein DivIC PF04977.15 ADV24447.1 - 0.28 11.0 49.4 0.19 11.5 1.3 8.8 6 3 3 9 9 9 0 Septum formation initiator FlaC_arch PF05377.11 ADV24447.1 - 1.4 9.4 29.4 0.78 10.2 0.2 7.4 7 1 2 9 9 8 0 Flagella accessory protein C (FlaC) DUF1664 PF07889.12 ADV24447.1 - 3.9 7.5 27.6 0.36 10.9 2.2 5.1 5 0 0 5 5 5 0 Protein of unknown function (DUF1664) DUF5082 PF16888.5 ADV24447.1 - 6.3 7.1 33.0 0.14 12.4 10.8 4.8 4 1 0 5 5 5 0 Domain of unknown function (DUF5082) TMF_TATA_bd PF12325.8 ADV24447.1 - 9.1 6.5 64.6 0.069 13.4 2.6 7.4 3 2 4 7 7 7 0 TATA element modulatory factor 1 TATA binding DS PF01916.17 ADV24448.1 - 8.8e-122 405.9 0.0 8.2e-120 399.4 0.0 2.0 1 1 0 1 1 1 1 Deoxyhypusine synthase Pan3_PK PF18101.1 ADV24449.1 - 5.3e-63 211.1 0.0 7.5e-63 210.6 0.0 1.2 1 0 0 1 1 1 1 Pan3 Pseudokinase domain Pkinase PF00069.25 ADV24449.1 - 8.3e-07 28.6 0.0 1.3e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV24449.1 - 0.00027 20.3 0.0 0.00042 19.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase zf-CCCH PF00642.24 ADV24449.1 - 0.18 11.8 0.3 0.4 10.7 0.3 1.5 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) XET_C PF06955.12 ADV24449.1 - 3.8 7.4 5.5 0.32 10.9 0.1 2.0 2 0 0 2 2 2 0 Xyloglucan endo-transglycosylase (XET) C-terminus BolA PF01722.18 ADV24450.1 - 2.1e-29 101.6 0.8 2.9e-29 101.1 0.8 1.2 1 0 0 1 1 1 1 BolA-like protein Sedlin_N PF04628.13 ADV24451.1 - 1.7e-31 109.1 0.0 1.5e-28 99.5 0.0 2.1 2 0 0 2 2 2 2 Sedlin, N-terminal conserved region Sybindin PF04099.12 ADV24451.1 - 2.9e-07 30.5 0.0 3.7e-07 30.1 0.0 1.2 1 0 0 1 1 1 1 Sybindin-like family DUF3123 PF11321.8 ADV24451.1 - 0.17 12.5 2.6 0.33 11.6 2.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3123) Ran_BP1 PF00638.18 ADV24452.1 - 1e-16 61.3 0.0 1.9e-16 60.4 0.0 1.4 1 0 0 1 1 1 1 RanBP1 domain CDC45 PF02724.14 ADV24452.1 - 8.1 4.6 9.0 12 4.0 9.0 1.3 1 0 0 1 1 1 0 CDC45-like protein JAB PF01398.21 ADV24453.1 - 1.1e-25 90.0 0.1 1.7e-25 89.3 0.1 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease CSN5_C PF18323.1 ADV24453.1 - 1.1e-19 71.1 7.1 2.2e-19 70.1 7.1 1.5 1 0 0 1 1 1 1 Cop9 signalosome subunit 5 C-terminal domain Prok-JAB PF14464.6 ADV24453.1 - 4e-05 23.4 0.0 6.9e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain PRKG1_interact PF15898.5 ADV24453.1 - 0.095 13.6 3.4 0.18 12.7 3.4 1.4 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain MKT1_C PF12246.8 ADV24454.1 - 9.5e-76 254.2 0.0 1.6e-73 246.9 0.0 2.1 2 0 0 2 2 2 2 Temperature dependent protein affecting M2 dsRNA replication MKT1_N PF12247.8 ADV24454.1 - 9.7e-23 80.3 0.0 2.9e-22 78.8 0.0 1.9 2 0 0 2 2 2 1 Temperature dependent protein affecting M2 dsRNA replication XPG_N PF00752.17 ADV24454.1 - 6e-10 39.5 0.0 2.8e-09 37.3 0.0 2.1 2 0 0 2 2 2 1 XPG N-terminal domain XPG_I PF00867.18 ADV24454.1 - 0.0011 19.3 0.0 0.0021 18.4 0.0 1.5 1 0 0 1 1 1 1 XPG I-region Zn_clus PF00172.18 ADV24455.1 - 2.3e-06 27.6 12.9 4.7e-06 26.6 12.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pro_isomerase PF00160.21 ADV24456.1 - 2.8e-42 144.7 0.0 2.8e-42 144.7 0.0 2.4 3 0 0 3 3 3 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DUF4604 PF15377.6 ADV24456.1 - 0.0011 19.4 0.3 0.0011 19.4 0.3 3.5 2 1 0 2 2 2 1 Domain of unknown function (DUF4604) HLH PF00010.26 ADV24457.1 - 2.8e-05 24.0 0.0 0.0001 22.2 0.0 2.0 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain RP-C_C PF11800.8 ADV24457.1 - 2.2 8.4 6.9 0.12 12.5 0.9 1.9 2 0 0 2 2 2 0 Replication protein C C-terminal region DUF4611 PF15387.6 ADV24457.1 - 5.2 7.4 9.7 1.5 9.1 4.6 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) WD40 PF00400.32 ADV24458.1 - 1.6e-17 63.5 12.8 1e-05 26.1 0.1 5.5 5 0 0 5 5 5 5 WD domain, G-beta repeat bZIP_2 PF07716.15 ADV24459.1 - 8.4e-11 41.8 16.0 8.4e-11 41.8 16.0 1.9 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_1 PF00170.21 ADV24459.1 - 4.9e-06 26.6 12.4 4.9e-06 26.6 12.4 2.1 2 0 0 2 2 2 1 bZIP transcription factor HOOK PF05622.12 ADV24459.1 - 0.00053 18.3 0.6 0.00071 17.9 0.6 1.1 1 0 0 1 1 1 1 HOOK protein TSC22 PF01166.18 ADV24459.1 - 0.041 14.2 0.5 0.094 13.0 0.5 1.6 1 0 0 1 1 1 0 TSC-22/dip/bun family HALZ PF02183.18 ADV24459.1 - 0.067 13.4 0.8 0.17 12.1 0.8 1.7 1 0 0 1 1 1 0 Homeobox associated leucine zipper YabA PF06156.13 ADV24459.1 - 0.072 13.7 0.2 0.17 12.6 0.2 1.7 1 0 0 1 1 1 0 Initiation control protein YabA ECM11 PF15463.6 ADV24459.1 - 0.11 13.1 4.8 0.11 13.0 0.2 2.3 2 0 0 2 2 2 0 Extracellular mutant protein 11 NRBF2 PF08961.10 ADV24459.1 - 1.2 8.6 9.6 0.13 11.9 4.8 1.7 2 0 0 2 2 2 0 Nuclear receptor-binding factor 2, autophagy regulator PRKG1_interact PF15898.5 ADV24459.1 - 3.1 8.8 11.9 0.18 12.7 6.3 1.8 2 1 0 2 2 2 0 cGMP-dependent protein kinase interacting domain bZIP_Maf PF03131.17 ADV24459.1 - 4.1 8.0 12.9 0.26 11.8 7.3 1.9 2 0 0 2 2 2 0 bZIP Maf transcription factor TFIIA PF03153.13 ADV24459.1 - 7.5 6.4 14.5 9.6 6.1 14.5 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Metallophos PF00149.28 ADV24460.1 - 4e-30 105.8 0.4 8.8e-30 104.7 0.4 1.6 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PS_Dcarbxylase PF02666.15 ADV24461.1 - 5.2e-57 192.6 0.0 7.5e-57 192.1 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase C2 PF00168.30 ADV24461.1 - 1.1e-32 112.4 0.0 2.1e-19 69.7 0.0 2.5 2 0 0 2 2 2 2 C2 domain EF-hand_7 PF13499.6 ADV24461.1 - 0.022 15.2 0.1 0.057 13.9 0.1 1.8 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.6 ADV24461.1 - 0.15 12.0 0.1 1.1 9.4 0.0 2.5 2 0 0 2 2 2 0 EF-hand domain Rxt3 PF08642.10 ADV24464.1 - 5.9e-11 43.2 14.9 4.3e-08 34.0 0.8 4.8 3 1 1 4 4 4 2 Histone deacetylation protein Rxt3 LCCL PF03815.19 ADV24464.1 - 0.0022 18.0 0.0 0.0052 16.9 0.0 1.5 1 0 0 1 1 1 1 LCCL domain DUF3079 PF11278.8 ADV24464.1 - 0.071 12.9 0.1 0.19 11.6 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3079) Dabb PF07876.12 ADV24465.1 - 1.1e-17 64.5 0.0 1.5e-17 64.0 0.0 1.2 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain ABM PF03992.16 ADV24465.1 - 0.023 14.8 0.0 0.034 14.3 0.0 1.3 1 0 0 1 1 1 0 Antibiotic biosynthesis monooxygenase SDA1 PF05285.12 ADV24466.1 - 0.098 12.1 34.1 0.33 10.3 11.5 2.2 2 0 0 2 2 2 0 SDA1 Ras PF00071.22 ADV24467.1 - 2e-47 160.8 0.0 2.7e-47 160.4 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ADV24467.1 - 6.4e-20 71.6 0.0 8.7e-20 71.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ADV24467.1 - 4.5e-08 32.8 0.0 6.6e-08 32.2 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 ADV24467.1 - 0.0031 17.0 0.0 0.0041 16.6 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 ADV24467.1 - 0.016 14.6 0.0 0.023 14.0 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 ADV24467.1 - 0.031 13.8 0.2 0.076 12.5 0.0 1.7 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain DLIC PF05783.11 ADV24467.1 - 0.1 11.4 0.0 0.21 10.4 0.0 1.4 1 1 0 1 1 1 0 Dynein light intermediate chain (DLIC) Stealth_CR3 PF17102.5 ADV24468.1 - 4.9e-11 42.4 0.1 1.9e-10 40.5 0.1 2.1 1 0 0 1 1 1 1 Stealth protein CR3, conserved region 3 Stealth_CR4 PF17103.5 ADV24468.1 - 4.9e-11 42.3 0.2 2.2e-10 40.2 0.0 2.3 2 0 0 2 2 2 1 Stealth protein CR4, conserved region 4 Stealth_CR2 PF11380.8 ADV24468.1 - 9.4e-11 41.9 0.0 9.4e-09 35.4 0.0 2.5 2 0 0 2 2 2 1 Stealth protein CR2, conserved region 2 Stealth_CR1 PF17101.5 ADV24468.1 - 0.002 17.8 0.9 0.002 17.8 0.9 2.2 3 0 0 3 3 3 1 Stealth protein CR1, conserved region 1 Proteasome PF00227.26 ADV24470.1 - 1e-43 149.1 0.0 1e-43 149.1 0.0 1.4 2 0 0 2 2 2 1 Proteasome subunit Proteasome_A_N PF10584.9 ADV24470.1 - 5.5e-14 51.5 0.1 8.6e-14 50.9 0.1 1.3 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature TFA2_Winged_2 PF18121.1 ADV24471.1 - 1e-16 60.4 0.0 2.3e-16 59.2 0.0 1.7 1 0 0 1 1 1 1 TFA2 Winged helix domain 2 Pkinase PF00069.25 ADV24472.1 - 1.1e-69 234.7 0.0 1.4e-69 234.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV24472.1 - 2.1e-49 168.1 0.0 2.9e-49 167.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ADV24472.1 - 2.8e-06 26.4 0.3 5.9e-06 25.3 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 ADV24472.1 - 0.0077 15.6 0.0 0.016 14.6 0.0 1.6 1 0 0 1 1 1 1 Kinase-like Phage_TTP_13 PF16463.5 ADV24472.1 - 0.044 13.3 0.0 0.084 12.4 0.0 1.4 1 0 0 1 1 1 0 Phage tail tube protein family Zw10 PF06248.13 ADV24473.1 - 1.2e-07 30.7 4.1 0.00051 18.7 1.2 2.8 2 2 0 2 2 2 2 Centromere/kinetochore Zw10 Resolvase PF00239.21 ADV24473.1 - 0.041 14.0 0.0 0.12 12.5 0.0 1.8 1 0 0 1 1 1 0 Resolvase, N terminal domain DUF2477 PF10631.9 ADV24473.1 - 2.2 9.0 8.8 8.8 7.0 1.4 3.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2477) Ndc1_Nup PF09531.10 ADV24473.1 - 8.4 4.9 9.2 19 3.8 9.2 1.6 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Hist_deacetyl PF00850.19 ADV24474.1 - 6.9e-81 272.1 0.0 9.6e-81 271.6 0.0 1.2 1 0 0 1 1 1 1 Histone deacetylase domain Synaptobrevin PF00957.21 ADV24475.1 - 8.8e-34 115.2 2.3 1e-33 115.0 2.3 1.0 1 0 0 1 1 1 1 Synaptobrevin Sec20 PF03908.13 ADV24475.1 - 0.04 13.8 0.1 0.057 13.3 0.1 1.2 1 0 0 1 1 1 0 Sec20 UPF0258 PF06789.12 ADV24475.1 - 0.083 13.0 1.7 0.13 12.4 1.7 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0258) Prominin PF05478.11 ADV24475.1 - 0.086 10.8 0.5 0.12 10.4 0.5 1.1 1 0 0 1 1 1 0 Prominin MCU PF04678.13 ADV24475.1 - 0.1 12.7 0.0 0.12 12.5 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial calcium uniporter GP41 PF00517.17 ADV24475.1 - 0.12 12.3 3.2 0.51 10.2 3.2 1.7 1 1 0 1 1 1 0 Retroviral envelope protein FlaC_arch PF05377.11 ADV24475.1 - 0.14 12.6 0.2 3.3 8.2 0.3 2.1 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Fzo_mitofusin PF04799.13 ADV24475.1 - 0.26 10.8 1.7 0.18 11.3 0.2 1.5 1 1 0 1 1 1 0 fzo-like conserved region DUF948 PF06103.11 ADV24475.1 - 0.53 10.6 8.0 2.9 8.2 0.2 2.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) PRIMA1 PF16101.5 ADV24475.1 - 1.2 9.1 4.5 0.98 9.5 1.1 2.0 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 Mito_carr PF00153.27 ADV24476.1 - 1.9e-60 200.8 7.8 6.4e-23 80.5 0.1 3.5 3 1 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 ADV24476.1 - 0.0013 17.9 0.1 0.21 10.7 0.0 2.2 1 1 0 2 2 2 2 Gammaproteobacterial serine protease LSM14 PF12701.7 ADV24477.1 - 8.7e-13 48.2 0.0 1.3e-12 47.6 0.0 1.3 1 0 0 1 1 1 1 Scd6-like Sm domain FDF PF09532.10 ADV24477.1 - 2.7e-08 34.6 0.7 9e-08 32.9 0.8 1.8 2 0 0 2 2 2 1 FDF domain GRP PF07172.11 ADV24477.1 - 0.028 15.1 27.2 0.053 14.2 27.2 1.4 1 0 0 1 1 1 0 Glycine rich protein family SM-ATX PF14438.6 ADV24477.1 - 0.043 13.9 0.0 0.09 12.9 0.0 1.4 1 0 0 1 1 1 0 Ataxin 2 SM domain Trimer_CC PF08954.11 ADV24477.1 - 0.14 11.7 0.7 5.5 6.6 0.1 2.7 2 0 0 2 2 2 0 Trimerisation motif Pet191_N PF10203.9 ADV24478.1 - 4.9e-23 81.2 3.7 6.4e-23 80.8 3.7 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein PET191 Cmc1 PF08583.10 ADV24478.1 - 0.7 10.0 4.0 15 5.7 0.1 2.5 1 1 0 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like Glyco_transf_20 PF00982.21 ADV24479.1 - 1.2e-186 621.1 0.0 2e-137 458.7 0.0 2.0 2 0 0 2 2 2 2 Glycosyltransferase family 20 Glyco_trans_1_4 PF13692.6 ADV24479.1 - 0.0052 17.2 0.0 0.012 16.1 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 ADV24479.1 - 0.05 13.1 0.1 7.5 6.1 0.0 2.5 2 1 0 2 2 2 0 Glycosyl transferases group 1 FrhB_FdhB_N PF04422.13 ADV24479.1 - 0.094 12.9 0.3 2.5 8.3 0.2 2.4 2 0 0 2 2 2 0 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term Glyco_transf_8 PF01501.20 ADV24480.1 - 7.1e-16 58.5 0.0 2.2e-15 56.9 0.0 1.8 1 1 0 1 1 1 1 Glycosyl transferase family 8 Mito_carr PF00153.27 ADV24481.1 - 9.5e-50 166.5 3.9 6.2e-16 58.1 0.1 4.4 4 0 0 4 4 4 4 Mitochondrial carrier protein Mito_carr PF00153.27 ADV24482.1 - 8.3e-17 60.9 7.7 7.9e-09 35.3 0.2 3.7 3 0 0 3 3 3 3 Mitochondrial carrier protein Mem_trans PF03547.18 ADV24482.1 - 5.5e-07 28.3 5.5 1.9e-06 26.6 3.4 2.5 1 1 1 2 2 2 1 Membrane transport protein Imp-YgjV PF10688.9 ADV24482.1 - 0.26 11.1 5.4 1 9.1 5.4 2.1 1 0 0 1 1 1 0 Bacterial inner membrane protein Amino_oxidase PF01593.24 ADV24483.1 - 7.4e-10 38.7 0.0 3.6e-07 29.8 0.0 2.2 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 ADV24483.1 - 2.8e-06 27.4 0.1 1.1e-05 25.6 0.1 2.1 1 1 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 ADV24483.1 - 0.0012 18.9 0.0 0.6 10.1 0.0 2.6 3 0 0 3 3 3 2 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 ADV24483.1 - 0.0032 16.7 0.0 0.08 12.2 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ADV24483.1 - 0.0035 17.0 0.8 0.014 15.0 0.1 2.2 3 0 0 3 3 3 1 FAD dependent oxidoreductase NIPSNAP PF07978.13 ADV24484.1 - 6.5e-32 109.8 0.6 1.7e-22 79.6 0.2 2.1 2 0 0 2 2 2 2 NIPSNAP Rab5-bind PF09311.11 ADV24485.1 - 0.61 9.4 19.6 0.95 8.8 19.6 1.2 1 0 0 1 1 1 0 Rabaptin-like protein Vip3A_N PF12495.8 ADV24486.1 - 0.012 15.6 1.8 0.018 14.9 0.6 1.8 1 1 0 1 1 1 0 Vegetative insecticide protein 3A N terminal CENP-F_leu_zip PF10473.9 ADV24486.1 - 0.023 14.7 3.1 0.023 14.7 3.1 5.0 1 1 4 5 5 5 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 MCC-bdg_PDZ PF10506.9 ADV24486.1 - 0.072 13.1 4.7 0.72 9.9 0.1 3.9 3 0 0 3 3 3 0 PDZ domain of MCC-2 bdg protein for Usher syndrome Glutaredoxin2_C PF04399.13 ADV24486.1 - 0.36 10.7 3.1 0.49 10.2 0.1 2.7 2 1 0 2 2 2 0 Glutaredoxin 2, C terminal domain Filament PF00038.21 ADV24486.1 - 4.6 6.7 38.4 1.5 8.3 12.5 3.3 1 1 3 4 4 4 0 Intermediate filament protein MIOX PF05153.15 ADV24487.1 - 6.6e-117 389.5 0.3 8.9e-117 389.1 0.3 1.2 1 0 0 1 1 1 1 Myo-inositol oxygenase HD PF01966.22 ADV24487.1 - 0.0044 17.2 0.0 0.31 11.3 0.0 2.4 2 0 0 2 2 2 2 HD domain AP_endonuc_2 PF01261.24 ADV24488.1 - 2.8e-18 66.1 0.0 4.4e-18 65.5 0.0 1.3 1 1 0 1 1 1 1 Xylose isomerase-like TIM barrel GFO_IDH_MocA PF01408.22 ADV24489.1 - 9.8e-22 78.0 0.4 4e-21 76.1 0.2 2.0 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ADV24489.1 - 1.6e-07 31.4 0.0 4.2e-07 30.0 0.0 1.7 2 0 0 2 2 2 1 Oxidoreductase family, C-terminal alpha/beta domain NAD_binding_2 PF03446.15 ADV24489.1 - 0.021 15.0 0.0 0.61 10.3 0.0 2.2 1 1 1 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.18 ADV24489.1 - 0.034 14.0 0.0 0.056 13.3 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Gp_dh_N PF00044.24 ADV24489.1 - 0.1 13.0 0.0 0.92 9.9 0.0 2.3 2 0 0 2 2 2 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 ADV24489.1 - 0.17 11.2 0.0 0.31 10.4 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GFO_IDH_MocA PF01408.22 ADV24490.1 - 4.2e-24 85.7 0.1 8.1e-23 81.5 0.1 2.2 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ADV24490.1 - 3.7e-08 33.4 0.0 9.1e-08 32.1 0.0 1.8 1 1 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain F420_oxidored PF03807.17 ADV24490.1 - 0.0033 18.0 0.0 0.0067 17.0 0.0 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_3 PF03447.16 ADV24490.1 - 0.0089 16.7 0.1 0.014 16.1 0.1 1.3 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 ADV24490.1 - 0.016 15.3 0.0 0.044 14.0 0.0 1.7 2 1 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.18 ADV24490.1 - 0.024 14.5 0.0 0.039 13.8 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Gp_dh_N PF00044.24 ADV24490.1 - 0.054 13.8 0.0 0.37 11.1 0.0 2.2 2 0 0 2 2 2 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain Sugar_tr PF00083.24 ADV24491.1 - 2.2e-95 320.2 14.7 1.7e-92 310.6 11.8 2.1 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 ADV24491.1 - 4.9e-22 78.3 26.1 2.3e-16 59.7 5.3 2.8 2 1 1 3 3 3 2 Major Facilitator Superfamily OATP PF03137.20 ADV24491.1 - 0.00072 18.0 0.3 0.00072 18.0 0.3 1.9 2 0 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family Ni_hydr_CYTB PF01292.20 ADV24491.1 - 0.0015 18.1 2.5 0.0015 18.1 2.5 1.8 2 0 0 2 2 2 1 Prokaryotic cytochrome b561 Sugar_tr PF00083.24 ADV24492.1 - 8.7e-128 427.0 24.7 1e-127 426.7 24.7 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ADV24492.1 - 2.4e-20 72.8 39.2 2e-15 56.6 17.3 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Brr6_like_C_C PF10104.9 ADV24492.1 - 0.25 11.1 2.2 0.47 10.2 1.1 2.0 2 0 0 2 2 2 0 Di-sulfide bridge nucleocytoplasmic transport domain USP19_linker PF16602.5 ADV24493.1 - 0.017 15.7 0.1 0.02 15.5 0.1 1.2 1 0 0 1 1 1 0 Linker region of USP19 deubiquitinase Zn_clus PF00172.18 ADV24494.1 - 0.014 15.5 13.6 0.04 14.1 13.6 1.8 1 1 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 ADV24494.1 - 0.014 14.5 0.0 0.025 13.6 0.0 1.4 1 0 0 1 1 1 0 Fungal specific transcription factor domain Spc7_N PF15402.6 ADV24494.1 - 7.6 4.7 10.8 11 4.2 10.8 1.1 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 Fungal_trans PF04082.18 ADV24495.1 - 2.1e-06 27.0 0.1 3.1e-06 26.4 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Glyco_hydro_3 PF00933.21 ADV24495.1 - 0.094 12.1 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 3 N terminal domain PhyH PF05721.13 ADV24496.1 - 1e-21 78.2 0.1 1.5e-21 77.7 0.1 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) GST_C_4 PF14834.6 ADV24496.1 - 0.15 12.5 0.0 0.26 11.7 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain ArfGap PF01412.18 ADV24497.1 - 1.6e-32 112.0 0.2 1.6e-32 112.0 0.2 1.7 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf NAM-associated PF14303.6 ADV24497.1 - 0.33 11.7 14.1 0.64 10.7 14.1 1.5 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain Borrelia_P83 PF05262.11 ADV24497.1 - 0.66 8.4 9.4 0.97 7.8 9.4 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein PRCC PF10253.9 ADV24497.1 - 8.6 7.1 19.0 8.4 7.1 15.6 2.2 2 0 0 2 2 2 0 Mitotic checkpoint regulator, MAD2B-interacting DUF3546 PF12066.8 ADV24499.1 - 2.4e-20 72.7 0.6 2.4e-20 72.7 0.6 2.7 2 0 0 2 2 2 1 Domain of unknown function (DUF3546) ARS2 PF04959.13 ADV24499.1 - 7.9e-14 52.5 4.7 7.9e-14 52.5 4.7 3.0 2 1 0 2 2 2 1 Arsenite-resistance protein 2 RRM_1 PF00076.22 ADV24499.1 - 1.2e-05 25.0 0.0 2.2e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C2H2 PF00096.26 ADV24499.1 - 0.014 15.8 0.8 0.037 14.5 0.8 1.8 1 0 0 1 1 1 0 Zinc finger, C2H2 type Hid1 PF12722.7 ADV24499.1 - 5.9 4.9 4.7 10 4.1 4.7 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RVP_2 PF08284.11 ADV24500.1 - 0.0053 16.5 0.0 0.16 11.8 0.0 2.2 2 0 0 2 2 2 2 Retroviral aspartyl protease SPRY PF00622.28 ADV24501.1 - 2e-14 53.7 0.4 1.5e-12 47.7 0.0 3.1 3 0 0 3 3 3 1 SPRY domain Serglycin PF04360.12 ADV24501.1 - 9.3 6.2 14.0 7.4 6.5 0.6 3.7 3 0 0 3 3 3 0 Serglycin CTNNBL PF08216.11 ADV24502.1 - 7.5e-32 109.6 0.0 2e-31 108.2 0.0 1.8 1 0 0 1 1 1 1 Catenin-beta-like, Arm-motif containing nuclear Arm PF00514.23 ADV24502.1 - 0.0007 19.5 0.1 0.0059 16.6 0.0 2.5 2 0 0 2 2 2 1 Armadillo/beta-catenin-like repeat DUF3384 PF11864.8 ADV24502.1 - 0.0059 15.6 0.7 0.028 13.4 0.7 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF3384) Mo25 PF08569.11 ADV24502.1 - 0.035 13.5 3.8 0.78 9.0 3.9 2.4 1 1 0 1 1 1 0 Mo25-like Asp_Glu_race_2 PF14669.6 ADV24502.1 - 0.09 12.4 0.0 0.18 11.4 0.0 1.5 1 0 0 1 1 1 0 Putative aspartate racemase PP2C_2 PF13672.6 ADV24503.1 - 9.7e-08 31.9 0.0 1.2e-05 25.0 0.0 2.2 2 0 0 2 2 2 2 Protein phosphatase 2C SpoIIE PF07228.12 ADV24503.1 - 2.9e-07 30.6 0.0 1.1e-06 28.7 0.0 1.8 2 0 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) PP2C PF00481.21 ADV24503.1 - 0.00065 19.4 0.2 0.029 14.0 0.0 2.2 2 0 0 2 2 2 1 Protein phosphatase 2C Tsc35 PF15079.6 ADV24503.1 - 0.2 11.2 0.1 0.32 10.5 0.1 1.2 1 0 0 1 1 1 0 Testis-specific protein 35 ICL PF00463.21 ADV24504.1 - 4e-243 807.7 0.0 4.7e-243 807.4 0.0 1.0 1 0 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.6 ADV24504.1 - 1.7e-08 34.3 0.0 3e-08 33.4 0.0 1.3 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase DUF1899 PF08953.11 ADV24505.1 - 2.4e-23 81.8 0.1 5e-23 80.7 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40_4 PF16300.5 ADV24505.1 - 5.4e-20 71.0 0.5 1e-19 70.1 0.5 1.5 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.32 ADV24505.1 - 1.3e-15 57.5 8.2 0.00064 20.5 0.0 5.6 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV24505.1 - 1.4e-05 25.3 0.0 0.018 15.3 0.0 3.6 3 1 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain DUF4232 PF14016.6 ADV24505.1 - 0.064 13.4 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4232) Ge1_WD40 PF16529.5 ADV24505.1 - 0.066 12.2 0.0 5.8 5.8 0.0 2.3 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein dUTPase PF00692.19 ADV24506.1 - 2.1e-45 153.5 0.0 2.5e-45 153.3 0.0 1.0 1 0 0 1 1 1 1 dUTPase Aldo_ket_red PF00248.21 ADV24507.1 - 4.8e-46 157.3 0.0 5e-38 131.0 0.0 2.0 2 0 0 2 2 2 2 Aldo/keto reductase family Ion_trans PF00520.31 ADV24509.1 - 0.00053 19.3 1.4 0.0007 18.9 1.4 1.1 1 0 0 1 1 1 1 Ion transport protein WD40 PF00400.32 ADV24511.1 - 1.1e-38 130.5 29.4 2.7e-08 34.3 0.2 7.9 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV24511.1 - 9.2e-15 54.7 2.3 0.016 15.5 0.0 6.6 2 1 4 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ADV24511.1 - 2.3e-10 39.8 2.6 0.14 10.8 0.0 5.1 3 1 2 5 5 5 5 Nucleoporin Nup120/160 WD40_like PF17005.5 ADV24511.1 - 4e-06 26.4 0.0 0.016 14.5 0.0 2.8 2 1 1 3 3 3 2 WD40-like domain DUF5046 PF16465.5 ADV24511.1 - 0.023 14.1 0.0 1.5 8.2 0.0 2.6 1 1 2 3 3 3 0 Domain of unknown function (DUF5046) PQQ_3 PF13570.6 ADV24511.1 - 0.038 14.5 1.1 21 5.7 0.1 3.8 3 0 0 3 3 3 0 PQQ-like domain Ge1_WD40 PF16529.5 ADV24511.1 - 0.43 9.5 5.2 2.3 7.1 0.2 3.1 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Rrn6 PF10214.9 ADV24512.1 - 1.5e-16 60.2 13.9 1e-09 37.5 6.4 3.1 2 1 1 3 3 3 2 RNA polymerase I-specific transcription-initiation factor TFIID-18kDa PF02269.16 ADV24513.1 - 3.6e-31 107.0 0.6 8.6e-31 105.8 0.4 1.7 2 0 0 2 2 2 1 Transcription initiation factor IID, 18kD subunit TFIIE-A_C PF11521.8 ADV24513.1 - 0.011 16.1 9.9 0.044 14.1 2.8 2.6 2 0 0 2 2 2 0 C-terminal general transcription factor TFIIE alpha SRP_SPB PF02978.19 ADV24513.1 - 0.077 13.6 0.2 0.18 12.4 0.2 1.6 1 0 0 1 1 1 0 Signal peptide binding domain Hus1 PF04005.12 ADV24514.1 - 7.8e-71 238.6 0.0 8.9e-71 238.4 0.0 1.0 1 0 0 1 1 1 1 Hus1-like protein PCNA_N PF00705.18 ADV24514.1 - 0.021 14.5 0.0 0.11 12.2 0.0 2.0 2 0 0 2 2 2 0 Proliferating cell nuclear antigen, N-terminal domain PAP2 PF01569.21 ADV24515.1 - 2.2e-09 37.2 0.4 2.2e-09 37.2 0.4 1.8 1 1 1 2 2 2 1 PAP2 superfamily UL42 PF17638.2 ADV24515.1 - 0.43 10.6 3.0 0.76 9.8 3.0 1.3 1 0 0 1 1 1 0 HCMV UL42 TB2_DP1_HVA22 PF03134.19 ADV24516.1 - 1.7e-05 24.6 0.2 3.7e-05 23.6 0.1 1.6 1 1 0 1 1 1 1 TB2/DP1, HVA22 family PhoLip_ATPase_C PF16212.5 ADV24517.1 - 1.9e-50 172.0 19.9 1.9e-50 172.0 19.9 2.9 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 ADV24517.1 - 1.8e-17 62.7 3.9 4.3e-17 61.6 3.9 1.6 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.20 ADV24517.1 - 1.7e-16 60.2 1.5 4.8e-16 58.8 0.1 2.5 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 ADV24517.1 - 1.1e-12 48.7 0.9 5.3e-07 30.1 0.3 3.2 3 1 0 3 3 3 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ADV24517.1 - 1.9e-08 34.3 0.0 2.3e-07 30.8 0.0 2.5 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 ADV24517.1 - 0.00049 19.9 0.0 0.0011 18.8 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase F-box-like PF12937.7 ADV24518.1 - 6e-12 45.3 1.7 6e-12 45.3 1.7 2.4 3 0 0 3 3 3 1 F-box-like LRR_6 PF13516.6 ADV24518.1 - 6.6e-12 44.5 20.8 0.0017 18.3 0.1 10.1 11 0 0 11 11 11 3 Leucine Rich repeat LRR_4 PF12799.7 ADV24518.1 - 1.4e-05 25.3 14.2 0.45 11.0 0.1 7.1 4 2 4 8 8 8 3 Leucine Rich repeats (2 copies) F-box PF00646.33 ADV24518.1 - 0.059 13.3 6.0 0.61 10.0 0.6 4.0 4 0 0 4 4 4 0 F-box domain LRR_1 PF00560.33 ADV24518.1 - 2.3 9.1 17.0 88 4.3 0.2 8.1 9 0 0 9 9 9 0 Leucine Rich Repeat WD40 PF00400.32 ADV24519.1 - 2.2e-12 47.2 8.8 0.0029 18.4 0.0 5.3 5 0 0 5 5 5 4 WD domain, G-beta repeat TFIIF_alpha PF05793.12 ADV24519.1 - 0.31 9.6 4.0 0.46 9.0 4.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) IMUP PF15761.5 ADV24519.1 - 1.4 9.6 8.2 6.6 7.5 1.4 2.6 2 0 0 2 2 2 0 Immortalisation up-regulated protein ARD PF03079.14 ADV24520.1 - 8.4e-45 152.8 0.0 1e-44 152.5 0.0 1.1 1 0 0 1 1 1 1 ARD/ARD' family Cupin_2 PF07883.11 ADV24520.1 - 3.9e-09 36.1 0.1 7.1e-09 35.3 0.1 1.4 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 ADV24520.1 - 9.4e-08 32.0 0.1 1.4e-07 31.5 0.1 1.2 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_1 PF00190.22 ADV24520.1 - 0.0023 17.6 0.0 0.0034 17.0 0.0 1.2 1 0 0 1 1 1 1 Cupin Cupin_3 PF05899.12 ADV24520.1 - 0.023 14.4 0.1 0.063 13.0 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF861) Cupin_6 PF12852.7 ADV24520.1 - 0.053 13.3 0.0 0.072 12.8 0.0 1.2 1 0 0 1 1 1 0 Cupin Trypan_PARP PF05887.11 ADV24521.1 - 6.4 6.8 14.4 10 6.1 0.3 3.2 3 0 0 3 3 3 0 Procyclic acidic repetitive protein (PARP) TruD PF01142.18 ADV24522.1 - 4.4e-74 249.8 0.0 1.8e-70 237.9 0.0 2.4 2 0 0 2 2 2 2 tRNA pseudouridine synthase D (TruD) API5 PF05918.11 ADV24522.1 - 0.97 8.2 4.1 1.4 7.7 4.1 1.2 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) Acetyltransf_3 PF13302.7 ADV24523.1 - 0.0096 16.6 0.0 1.9 9.2 0.0 2.4 1 1 1 2 2 2 2 Acetyltransferase (GNAT) domain FR47 PF08445.10 ADV24523.1 - 0.015 15.2 0.0 0.038 14.0 0.0 1.6 2 0 0 2 2 2 0 FR47-like protein TauD PF02668.16 ADV24524.1 - 0.061 13.1 0.8 0.11 12.3 0.8 1.3 1 0 0 1 1 1 0 Taurine catabolism dioxygenase TauD, TfdA family GATA PF00320.27 ADV24525.1 - 8.5e-14 50.9 4.6 1.9e-13 49.8 4.6 1.6 1 0 0 1 1 1 1 GATA zinc finger Zn-ribbon_8 PF09723.10 ADV24525.1 - 0.12 12.5 0.5 0.31 11.2 0.5 1.7 1 0 0 1 1 1 0 Zinc ribbon domain Nudix_N_2 PF14803.6 ADV24525.1 - 4.2 7.4 6.0 2.9 7.9 3.4 2.1 2 0 0 2 2 2 0 Nudix N-terminal ESCRT-II PF05871.12 ADV24526.1 - 7.5e-46 155.9 0.1 2.1e-45 154.4 0.0 1.6 2 0 0 2 2 2 1 ESCRT-II complex subunit DUF535 PF04393.13 ADV24526.1 - 0.15 11.3 0.0 0.22 10.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF535) GATase_2 PF00310.21 ADV24527.1 - 1.8e-178 593.6 0.0 2.4e-178 593.2 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Glu_synthase PF01645.17 ADV24527.1 - 3.9e-154 513.2 0.3 1.1e-152 508.4 0.0 2.7 3 0 0 3 3 3 1 Conserved region in glutamate synthase Glu_syn_central PF04898.14 ADV24527.1 - 1.8e-111 372.1 0.1 5e-109 364.1 0.0 2.2 2 0 0 2 2 2 1 Glutamate synthase central domain GXGXG PF01493.19 ADV24527.1 - 2e-86 288.5 1.8 3.5e-86 287.7 1.8 1.4 1 0 0 1 1 1 1 GXGXG motif Pyr_redox_2 PF07992.14 ADV24527.1 - 1.1e-26 93.7 0.0 8.1e-26 90.9 0.0 2.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Fer4_20 PF14691.6 ADV24527.1 - 8e-22 77.1 0.2 1.9e-21 75.9 0.2 1.7 1 0 0 1 1 1 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Pyr_redox_3 PF13738.6 ADV24527.1 - 3.8e-09 36.2 0.3 0.0055 16.0 0.0 3.4 2 1 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ADV24527.1 - 4.8e-09 36.3 0.0 1.7e-08 34.5 0.0 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 ADV24527.1 - 2.8e-07 30.2 0.1 5.8e-07 29.2 0.1 1.5 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase Pyr_redox PF00070.27 ADV24527.1 - 9.7e-07 29.3 2.5 3e-05 24.5 0.1 3.4 3 1 0 3 3 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ADV24527.1 - 1e-06 28.6 0.6 0.0014 18.2 0.2 2.5 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 ADV24527.1 - 1.9e-05 23.9 3.3 0.00017 20.8 0.1 2.7 3 0 0 3 3 3 1 FAD binding domain HI0933_like PF03486.14 ADV24527.1 - 3.6e-05 22.6 0.1 3.6e-05 22.6 0.1 1.8 2 0 0 2 2 2 1 HI0933-like protein FAD_oxidored PF12831.7 ADV24527.1 - 6.2e-05 22.5 0.2 6.2e-05 22.5 0.2 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 ADV24527.1 - 0.00034 20.0 0.0 0.0007 18.9 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain FMN_dh PF01070.18 ADV24527.1 - 0.00084 18.5 1.0 0.005 15.9 0.6 2.5 4 0 0 4 4 4 1 FMN-dependent dehydrogenase NAD_binding_7 PF13241.6 ADV24527.1 - 0.0011 19.3 0.1 0.54 10.7 0.1 3.0 3 0 0 3 3 2 1 Putative NAD(P)-binding Thi4 PF01946.17 ADV24527.1 - 0.0045 16.3 1.1 0.016 14.4 0.1 2.3 2 0 0 2 2 2 1 Thi4 family AlaDh_PNT_C PF01262.21 ADV24527.1 - 0.0097 15.2 0.1 0.39 10.0 0.0 2.3 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 ADV24527.1 - 0.011 14.9 0.5 0.08 12.0 0.1 2.2 2 0 0 2 2 2 0 Glucose inhibited division protein A FMO-like PF00743.19 ADV24527.1 - 0.025 13.0 0.1 0.36 9.2 0.0 2.3 3 0 0 3 3 3 0 Flavin-binding monooxygenase-like NAD_binding_2 PF03446.15 ADV24527.1 - 0.042 14.0 0.1 0.17 12.1 0.0 2.1 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.12 ADV24527.1 - 0.059 12.9 0.0 0.48 10.0 0.0 2.4 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain GATase_6 PF13522.6 ADV24527.1 - 0.06 13.5 0.0 0.16 12.2 0.0 1.7 1 0 0 1 1 1 0 Glutamine amidotransferase domain 2-Hacid_dh_C PF02826.19 ADV24527.1 - 0.075 12.4 0.4 0.26 10.6 0.0 2.1 2 0 0 2 2 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Lycopene_cycl PF05834.12 ADV24527.1 - 0.089 11.8 0.3 0.35 9.9 0.1 2.1 3 0 0 3 3 3 0 Lycopene cyclase protein SLT PF01464.20 ADV24528.1 - 2.5e-12 46.5 0.4 2.5e-12 46.5 0.4 2.4 2 1 0 2 2 2 1 Transglycosylase SLT domain PAP_assoc PF03828.19 ADV24529.1 - 8.2e-19 67.6 0.1 1.4e-18 66.8 0.1 1.4 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 ADV24529.1 - 0.0045 17.3 0.0 0.0087 16.3 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain Pyr_redox_2 PF07992.14 ADV24530.1 - 4.1e-66 223.2 8.0 6.2e-66 222.6 8.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 ADV24530.1 - 1.3e-42 144.5 0.2 3.9e-42 143.0 0.2 1.8 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 ADV24530.1 - 1.1e-19 70.7 8.5 1.2e-17 64.2 1.5 3.2 3 0 0 3 3 2 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 ADV24530.1 - 1.4e-12 47.4 5.0 1.4e-11 44.1 0.8 2.3 2 0 0 2 2 2 2 Glucose inhibited division protein A FAD_oxidored PF12831.7 ADV24530.1 - 1.7e-10 40.8 0.3 1.7e-10 40.8 0.3 3.0 2 1 1 3 3 3 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 ADV24530.1 - 6.8e-10 38.7 7.0 8.3e-07 28.5 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ADV24530.1 - 2.7e-08 33.9 3.6 1.4e-05 25.2 0.1 2.5 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 ADV24530.1 - 2.3e-07 30.4 10.5 0.0073 15.6 0.5 3.5 3 1 0 3 3 3 3 FAD binding domain FAD_binding_2 PF00890.24 ADV24530.1 - 5.1e-07 29.1 1.9 5.1e-07 29.1 1.9 3.7 4 1 1 5 5 5 1 FAD binding domain AlaDh_PNT_C PF01262.21 ADV24530.1 - 9.8e-07 28.3 4.0 0.0048 16.2 0.8 2.6 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain K_oxygenase PF13434.6 ADV24530.1 - 1.8e-06 27.4 0.5 0.014 14.5 0.0 2.8 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.17 ADV24530.1 - 3.2e-06 26.6 7.3 0.00025 20.3 0.1 2.6 2 1 0 2 2 2 2 Thi4 family HI0933_like PF03486.14 ADV24530.1 - 1.9e-05 23.5 14.2 0.00027 19.8 1.3 4.1 4 0 0 4 4 4 1 HI0933-like protein THF_DHG_CYH_C PF02882.19 ADV24530.1 - 0.0067 15.8 0.3 0.0067 15.8 0.3 2.1 3 0 0 3 3 3 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DAO PF01266.24 ADV24530.1 - 0.013 15.1 17.5 0.1 12.2 0.2 4.1 3 1 1 4 4 4 0 FAD dependent oxidoreductase XdhC_C PF13478.6 ADV24530.1 - 0.039 14.5 0.1 16 6.0 0.0 2.6 2 0 0 2 2 2 0 XdhC Rossmann domain NAD_binding_7 PF13241.6 ADV24530.1 - 0.52 10.8 4.8 2.9 8.4 1.2 3.3 3 1 0 3 3 3 0 Putative NAD(P)-binding Lycopene_cycl PF05834.12 ADV24530.1 - 1.6 7.7 6.9 0.84 8.6 0.3 2.9 3 1 0 3 3 3 0 Lycopene cyclase protein Dpoe2NT PF12213.8 ADV24531.1 - 0.17 12.2 0.3 0.93 9.8 0.1 2.1 2 0 0 2 2 2 0 DNA polymerases epsilon N terminal Tim17 PF02466.19 ADV24532.1 - 9.7e-21 74.2 5.6 1.5e-20 73.6 5.6 1.3 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family DUF4235 PF14019.6 ADV24532.1 - 0.027 14.6 0.0 0.3 11.2 0.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF4235) DEC-1_N PF04625.13 ADV24532.1 - 0.14 11.1 5.9 0.17 10.8 5.9 1.1 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region SDH_alpha PF03313.15 ADV24532.1 - 0.29 10.8 2.5 0.4 10.3 2.5 1.1 1 0 0 1 1 1 0 Serine dehydratase alpha chain EnY2 PF10163.9 ADV24533.1 - 1.8e-22 79.5 1.2 2.1e-22 79.3 1.2 1.1 1 0 0 1 1 1 1 Transcription factor e(y)2 Rib_5-P_isom_A PF06026.14 ADV24534.1 - 4.3e-59 199.0 0.0 5.8e-59 198.6 0.0 1.2 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) Myofilin PF15929.5 ADV24535.1 - 0.076 13.4 0.3 18 5.7 0.0 2.8 2 2 0 2 2 2 0 Myofilin Metallophos PF00149.28 ADV24537.1 - 3.6e-13 50.5 1.4 7.9e-13 49.4 0.6 2.2 2 1 0 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ADV24537.1 - 7.7e-07 29.4 0.1 0.00012 22.3 0.0 2.3 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase superfamily domain Scytalone_dh PF02982.14 ADV24537.1 - 0.039 13.8 0.0 0.089 12.6 0.0 1.5 1 0 0 1 1 1 0 Scytalone dehydratase Sugar_tr PF00083.24 ADV24539.1 - 2.4e-126 422.3 24.0 2.8e-126 422.0 24.0 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ADV24539.1 - 1.5e-20 73.4 25.3 1.5e-20 73.4 25.3 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Brr6_like_C_C PF10104.9 ADV24539.1 - 1.5 8.6 4.7 1 9.2 1.6 2.2 2 0 0 2 2 2 0 Di-sulfide bridge nucleocytoplasmic transport domain SHE3 PF17078.5 ADV24540.1 - 0.018 14.8 0.2 0.025 14.3 0.2 1.1 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 Bap31_Bap29_C PF18035.1 ADV24540.1 - 0.11 12.5 0.6 0.19 11.7 0.6 1.4 1 0 0 1 1 1 0 Bap31/Bap29 cytoplasmic coiled-coil domain Sod_Ni PF09055.11 ADV24540.1 - 0.14 12.7 0.1 0.23 12.0 0.1 1.2 1 0 0 1 1 1 0 Nickel-containing superoxide dismutase MCU PF04678.13 ADV24540.1 - 0.2 11.7 0.2 0.29 11.2 0.2 1.2 1 0 0 1 1 1 0 Mitochondrial calcium uniporter SAP130_C PF16014.5 ADV24540.1 - 0.54 9.3 7.9 0.048 12.7 1.6 1.9 2 0 0 2 2 2 0 Histone deacetylase complex subunit SAP130 C-terminus Ribosomal_L5_C PF00673.21 ADV24541.1 - 3.6e-21 75.1 0.0 5.8e-21 74.5 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 ADV24541.1 - 5.8e-21 74.6 0.1 1.2e-20 73.6 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein L5 SNARE PF05739.19 ADV24543.1 - 2.8e-13 49.6 0.1 6.4e-13 48.5 0.1 1.6 1 0 0 1 1 1 1 SNARE domain Syntaxin-5_N PF11416.8 ADV24543.1 - 1.2e-05 24.3 0.1 1.2e-05 24.3 0.1 2.2 2 0 0 2 2 2 1 Syntaxin-5 N-terminal, Sly1p-binding domain Syntaxin PF00804.25 ADV24543.1 - 0.00075 19.2 0.3 0.00075 19.2 0.3 2.9 2 1 1 3 3 3 1 Syntaxin Syntaxin-18_N PF10496.9 ADV24543.1 - 0.0037 17.5 2.6 0.0075 16.5 0.2 2.7 3 0 0 3 3 3 1 SNARE-complex protein Syntaxin-18 N-terminus SlyX PF04102.12 ADV24543.1 - 0.0063 17.1 1.2 0.32 11.6 0.3 3.0 2 0 0 2 2 2 1 SlyX FlxA PF14282.6 ADV24543.1 - 0.0098 15.9 0.3 0.0098 15.9 0.3 3.2 3 0 0 3 3 3 1 FlxA-like protein FlaC_arch PF05377.11 ADV24543.1 - 0.058 13.8 0.1 0.49 10.8 0.0 2.7 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) SF-assemblin PF06705.11 ADV24543.1 - 0.084 12.2 0.6 11 5.3 0.0 2.4 2 0 0 2 2 2 0 SF-assemblin/beta giardin Baculo_PEP_C PF04513.12 ADV24543.1 - 0.085 12.9 2.6 5.5 7.0 0.1 2.6 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1664 PF07889.12 ADV24543.1 - 0.14 12.2 2.4 2.3 8.3 0.6 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) BLOC1_2 PF10046.9 ADV24543.1 - 0.19 12.1 4.8 0.93 9.8 0.6 3.0 2 2 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF16 PF01519.16 ADV24543.1 - 0.3 11.6 2.4 0.49 10.9 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function DUF16 Cluap1 PF10234.9 ADV24543.1 - 0.48 9.8 3.4 5.2 6.4 0.1 2.3 2 0 0 2 2 2 0 Clusterin-associated protein-1 End3 PF12761.7 ADV24543.1 - 0.49 10.5 3.6 9.3 6.4 0.1 2.9 2 1 0 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 DUF5082 PF16888.5 ADV24543.1 - 0.52 10.6 4.9 11 6.4 0.9 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF5082) Prominin PF05478.11 ADV24543.1 - 0.58 8.0 3.1 0.19 9.7 0.5 1.4 2 0 0 2 2 2 0 Prominin NPV_P10 PF05531.12 ADV24543.1 - 0.65 10.5 4.3 3.2 8.3 0.0 3.0 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein LPP PF04728.13 ADV24543.1 - 1.2 9.5 4.6 12 6.4 0.1 3.1 3 1 0 3 3 2 0 Lipoprotein leucine-zipper Use1 PF09753.9 ADV24543.1 - 2.7 7.7 5.6 0.33 10.6 0.6 2.1 2 2 0 2 2 2 0 Membrane fusion protein Use1 Atg14 PF10186.9 ADV24543.1 - 4.7 6.2 5.9 5.9 5.9 0.0 2.3 2 1 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 bZIP_1 PF00170.21 ADV24544.1 - 9.8e-07 28.8 4.7 9.8e-07 28.8 4.7 1.8 2 0 0 2 2 2 1 bZIP transcription factor Cwf_Cwc_15 PF04889.12 ADV24544.1 - 0.0011 18.8 3.7 0.0016 18.2 3.7 1.1 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein bZIP_Maf PF03131.17 ADV24544.1 - 0.02 15.4 6.7 0.02 15.4 6.7 2.1 1 1 0 2 2 2 0 bZIP Maf transcription factor HIP1_clath_bdg PF16515.5 ADV24544.1 - 0.042 14.4 4.5 0.092 13.4 4.5 1.5 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 ASD2 PF08687.11 ADV24544.1 - 0.067 12.7 8.3 0.1 12.2 8.3 1.1 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 Slu7 PF11708.8 ADV24544.1 - 0.12 12.1 8.0 0.18 11.5 8.0 1.2 1 0 0 1 1 1 0 Pre-mRNA splicing Prp18-interacting factor Macoilin PF09726.9 ADV24544.1 - 0.21 10.1 11.1 0.28 9.7 11.1 1.0 1 0 0 1 1 1 0 Macoilin family FAM76 PF16046.5 ADV24544.1 - 0.28 10.5 10.6 0.4 10.0 10.6 1.1 1 0 0 1 1 1 0 FAM76 protein Bul1_N PF04425.12 ADV24544.1 - 3.6 6.2 8.5 5.5 5.6 8.5 1.2 1 0 0 1 1 1 0 Bul1 N terminus tRNA_U5-meth_tr PF05958.11 ADV24546.1 - 4.7e-13 48.9 0.0 4.8e-11 42.3 0.0 2.9 2 1 0 2 2 2 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_15 PF09445.10 ADV24546.1 - 2.2e-08 33.8 0.0 1.3e-07 31.3 0.0 2.0 2 0 0 2 2 2 1 RNA cap guanine-N2 methyltransferase Cons_hypoth95 PF03602.15 ADV24546.1 - 0.00048 19.8 0.0 0.0011 18.7 0.0 1.5 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_25 PF13649.6 ADV24546.1 - 0.00073 20.2 0.0 0.0014 19.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 ADV24546.1 - 0.012 15.0 0.0 0.02 14.3 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 ADV24546.1 - 0.015 14.9 0.0 0.026 14.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_11 PF08241.12 ADV24546.1 - 0.049 14.3 0.0 0.099 13.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 ADV24546.1 - 0.14 12.0 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Clathrin PF00637.20 ADV24547.1 - 6e-197 645.4 29.6 1.1e-31 109.6 0.3 8.2 8 0 0 8 8 8 8 Region in Clathrin and VPS Clathrin_H_link PF13838.6 ADV24547.1 - 5.6e-29 99.8 1.6 2.1e-28 98.0 0.1 2.8 2 0 0 2 2 2 1 Clathrin-H-link Clathrin_propel PF01394.20 ADV24547.1 - 3.1e-25 87.2 1.2 0.00029 21.0 0.1 7.0 6 1 0 6 6 6 5 Clathrin propeller repeat Clathrin-link PF09268.10 ADV24547.1 - 1.1e-11 43.8 0.2 1.1e-11 43.8 0.2 2.1 2 0 0 2 2 2 1 Clathrin, heavy-chain linker Coatomer_WDAD PF04053.14 ADV24547.1 - 0.0001 21.5 0.3 1.1 8.3 0.0 3.6 4 0 0 4 4 4 2 Coatomer WD associated region Vps39_1 PF10366.9 ADV24547.1 - 0.00049 20.4 2.0 4.7 7.5 0.0 5.4 6 1 0 6 6 6 1 Vacuolar sorting protein 39 domain 1 TPR_1 PF00515.28 ADV24547.1 - 0.019 14.8 2.7 29 4.7 0.0 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.6 ADV24547.1 - 0.027 15.3 15.7 44 5.3 0.1 9.0 10 0 0 10 10 10 0 Tetratricopeptide repeat TPR_2 PF07719.17 ADV24547.1 - 0.094 12.9 6.9 57 4.2 0.1 5.8 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.6 ADV24547.1 - 3.7 8.0 8.0 36 4.9 0.0 5.6 6 0 0 6 6 6 0 Tetratricopeptide repeat Mitofilin PF09731.9 ADV24548.1 - 0.61 8.8 21.8 0.61 8.9 21.8 1.2 1 0 0 1 1 1 0 Mitochondrial inner membrane protein SDA1 PF05285.12 ADV24548.1 - 0.63 9.4 21.1 0.67 9.3 21.1 1.2 1 0 0 1 1 1 0 SDA1 PAT1 PF09770.9 ADV24548.1 - 0.72 8.1 30.3 0.74 8.0 30.3 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Presenilin PF01080.17 ADV24548.1 - 1.3 7.7 23.3 1.2 7.8 23.3 1.1 1 0 0 1 1 1 0 Presenilin CCSAP PF15748.5 ADV24548.1 - 1.8 8.6 29.7 2 8.5 29.7 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated CDC45 PF02724.14 ADV24548.1 - 2 6.6 25.0 2.1 6.5 25.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Zip PF02535.22 ADV24548.1 - 2.2 7.4 12.5 2.2 7.4 12.5 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter DUF1387 PF07139.11 ADV24548.1 - 4.5 6.9 23.8 5.4 6.6 23.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) DUF2151 PF10221.9 ADV24548.1 - 9.1 4.7 10.7 7.7 5.0 10.7 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator DUF3760 PF12586.8 ADV24549.1 - 0.003 17.7 2.4 0.0067 16.6 2.4 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3760) cobW PF02492.19 ADV24550.1 - 2.4e-30 105.4 0.0 3.1e-30 105.1 0.0 1.1 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 ADV24550.1 - 0.0036 17.2 0.0 0.0069 16.3 0.0 1.4 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain Flu_PB2 PF00604.17 ADV24550.1 - 0.074 11.0 0.0 0.11 10.4 0.0 1.1 1 0 0 1 1 1 0 Influenza RNA-dependent RNA polymerase subunit PB2 CbiA PF01656.23 ADV24550.1 - 0.084 12.9 0.2 0.1 12.7 0.2 1.6 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain IHO1 PF15771.5 ADV24551.1 - 0.0062 15.4 0.8 0.013 14.3 0.8 1.5 1 0 0 1 1 1 1 Interactor of HORMAD1 protein 1 PAP1 PF08601.10 ADV24551.1 - 0.078 12.7 0.4 0.15 11.8 0.4 1.4 1 0 0 1 1 1 0 Transcription factor PAP1 MCM_bind PF09739.9 ADV24551.1 - 1.1 7.6 3.3 1.7 7.0 3.3 1.2 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Spc7_N PF15402.6 ADV24551.1 - 6.8 4.8 15.7 1.7 6.8 12.0 1.8 1 1 1 2 2 2 0 N-terminus of kinetochore NMS complex subunit Spc7 tRNA-synt_1b PF00579.25 ADV24552.1 - 6.6e-75 252.1 0.0 8.3e-75 251.8 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) DUF3760 PF12586.8 ADV24553.1 - 5.2e-06 26.5 3.7 9.1e-06 25.8 3.7 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3760) Ricin_B_lectin PF00652.22 ADV24554.1 - 6.7e-17 61.9 7.0 2.9e-12 46.9 1.6 1.5 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain RicinB_lectin_2 PF14200.6 ADV24554.1 - 5.4e-06 27.0 7.9 0.003 18.2 2.0 2.5 1 1 2 3 3 3 3 Ricin-type beta-trefoil lectin domain-like CDtoxinA PF03498.14 ADV24554.1 - 0.0061 16.2 0.2 3 7.4 0.1 2.6 2 1 0 2 2 2 2 Cytolethal distending toxin A/C domain BSP PF04450.12 ADV24556.1 - 1.6e-33 116.3 0.0 1e-30 107.1 0.0 2.1 2 0 0 2 2 2 2 Peptidase of plants and bacteria DUF3760 PF12586.8 ADV24557.1 - 2e-08 34.2 0.3 5.5e-08 32.9 0.3 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF3760) Holin_2-3 PF13272.6 ADV24558.1 - 0.11 12.8 3.0 0.1 12.9 0.8 2.1 2 0 0 2 2 2 0 Putative 2/3 transmembrane domain holin Ribosomal_S13 PF00416.22 ADV24559.1 - 2.4e-52 176.7 3.4 2.8e-52 176.5 3.4 1.0 1 0 0 1 1 1 1 Ribosomal protein S13/S18 FbpA PF05833.11 ADV24559.1 - 0.011 14.5 0.0 0.012 14.4 0.0 1.2 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) HHH_6 PF14579.6 ADV24559.1 - 0.029 14.6 0.1 0.093 13.0 0.1 1.9 1 1 0 1 1 1 0 Helix-hairpin-helix motif DUF2746 PF10874.8 ADV24559.1 - 0.063 13.7 0.0 0.1 13.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2746) DUF3760 PF12586.8 ADV24561.1 - 7.7e-06 26.0 0.6 2.3e-05 24.5 0.1 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF3760) hDGE_amylase PF14701.6 ADV24562.1 - 1.5e-153 512.1 0.0 2e-153 511.6 0.0 1.2 1 0 0 1 1 1 1 Glycogen debranching enzyme, glucanotransferase domain GDE_C PF06202.14 ADV24562.1 - 2.2e-118 395.5 0.0 3e-118 395.1 0.0 1.1 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase hGDE_central PF14702.6 ADV24562.1 - 7.4e-80 268.3 0.0 1.1e-79 267.7 0.0 1.3 1 0 0 1 1 1 1 Central domain of human glycogen debranching enzyme hGDE_N PF14699.6 ADV24562.1 - 1.6e-20 73.0 0.0 3.6e-20 71.9 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain from the human glycogen debranching enzyme Glyco_hydro_16 PF00722.21 ADV24563.1 - 4.2e-05 23.1 0.4 0.00012 21.6 0.0 1.9 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 Diphthami_syn_2 PF01902.17 ADV24567.1 - 6.7e-25 87.9 0.0 8.2e-25 87.6 0.0 1.1 1 0 0 1 1 1 1 Diphthamide synthase Diphthami_syn_2 PF01902.17 ADV24568.1 - 4.2e-25 88.5 0.0 6.5e-25 87.9 0.0 1.3 1 0 0 1 1 1 1 Diphthamide synthase Ribonuc_L-PSP PF01042.21 ADV24568.1 - 7e-13 48.7 0.0 0.00021 21.3 0.0 4.3 4 0 0 4 4 4 2 Endoribonuclease L-PSP KCH PF16944.5 ADV24569.1 - 2.2e-86 289.7 16.9 2.7e-86 289.4 16.9 1.1 1 0 0 1 1 1 1 Fungal potassium channel Gpr1_Fun34_YaaH PF01184.19 ADV24570.1 - 1.8e-56 191.0 12.2 2.3e-56 190.7 12.2 1.1 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family SUR7 PF06687.12 ADV24572.1 - 8.3e-09 35.4 0.0 8.8e-09 35.3 0.0 1.1 1 0 0 1 1 1 1 SUR7/PalI family PGG PF13962.6 ADV24572.1 - 0.023 14.5 0.0 0.053 13.3 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function Pyridoxal_deC PF00282.19 ADV24573.1 - 4.7e-68 229.6 0.0 6.3e-68 229.2 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 ADV24573.1 - 0.0011 18.0 0.0 0.002 17.2 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 ADV24573.1 - 0.082 12.2 0.1 0.56 9.5 0.0 2.0 1 1 1 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family Titin_Ig-rpts PF06582.12 ADV24574.1 - 0.11 12.4 0.0 0.25 11.3 0.0 1.6 1 0 0 1 1 1 0 Titin repeat Myb_DNA-binding PF00249.31 ADV24575.1 - 7.2e-14 51.7 0.8 1.6e-13 50.6 0.8 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ADV24575.1 - 7.4e-08 32.5 0.2 1.5e-07 31.5 0.2 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Exonuc_VII_L PF02601.15 ADV24575.1 - 0.17 11.5 5.7 0.3 10.6 5.7 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF5082 PF16888.5 ADV24575.1 - 0.39 11.0 3.6 0.8 10.0 3.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) SlyX PF04102.12 ADV24575.1 - 1.4 9.5 8.1 2.7 8.7 0.3 3.1 3 0 0 3 3 3 0 SlyX Alpha-amylase PF00128.24 ADV24576.1 - 3.7e-48 164.8 0.0 5.1e-48 164.4 0.0 1.1 1 0 0 1 1 1 1 Alpha amylase, catalytic domain DUF1966 PF09260.11 ADV24576.1 - 1.8e-20 73.0 1.7 3.1e-20 72.3 0.1 2.3 3 0 0 3 3 3 1 Domain of unknown function (DUF1966) SIR2 PF02146.17 ADV24577.1 - 3.6e-60 202.9 0.0 5.2e-60 202.4 0.0 1.2 1 0 0 1 1 1 1 Sir2 family DUF592 PF04574.13 ADV24577.1 - 6.4e-06 26.0 0.6 0.00013 21.8 0.2 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF592) TPP_enzyme_M PF00205.22 ADV24577.1 - 0.005 16.6 0.1 3.4 7.4 0.0 2.3 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, central domain DUF1272 PF06906.11 ADV24577.1 - 0.11 12.6 1.9 0.2 11.8 1.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) TT_ORF2 PF02957.15 ADV24577.1 - 3.8 8.5 8.5 0.91 10.5 0.4 3.0 3 0 0 3 3 3 0 TT viral ORF2 Peptidase_M24_C PF16188.5 ADV24578.1 - 0.06 13.4 0.0 21 5.2 0.0 2.8 2 0 0 2 2 2 0 C-terminal region of peptidase_M24 MPLKIP PF15502.6 ADV24578.1 - 1.4 9.2 5.7 84 3.5 0.1 3.5 3 0 0 3 3 3 0 M-phase-specific PLK1-interacting protein COesterase PF00135.28 ADV24579.1 - 6.7e-103 345.3 3.1 1.8e-102 343.8 3.1 1.6 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 ADV24579.1 - 3.7e-06 27.0 0.1 1.8e-05 24.7 0.1 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Mtc PF03820.17 ADV24580.1 - 8.6e-109 363.4 0.2 9.7e-109 363.2 0.2 1.0 1 0 0 1 1 1 1 Tricarboxylate carrier ATG_C PF09333.11 ADV24580.1 - 0.33 11.3 1.6 0.62 10.5 0.0 2.2 3 0 0 3 3 3 0 Autophagy-related protein C terminal domain Sugarporin_N PF11471.8 ADV24581.1 - 0.012 15.6 1.7 0.012 15.6 1.7 3.7 4 0 0 4 4 4 0 Maltoporin periplasmic N-terminal extension Laminin_II PF06009.12 ADV24581.1 - 0.12 12.4 20.2 0.092 12.8 15.3 2.4 2 0 0 2 2 2 0 Laminin Domain II Spc7 PF08317.11 ADV24581.1 - 0.14 11.0 44.9 0.052 12.4 31.7 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein TolA_bind_tri PF16331.5 ADV24581.1 - 0.24 11.5 9.0 0.055 13.6 2.3 2.6 1 1 1 2 2 2 0 TolA binding protein trimerisation Cas_DxTHG PF09455.10 ADV24581.1 - 0.33 10.5 9.2 0.55 9.8 9.2 1.3 1 0 0 1 1 1 0 CRISPR-associated (Cas) DxTHG family DUF3584 PF12128.8 ADV24581.1 - 1.2 6.6 30.9 1.7 6.1 30.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) FlaC_arch PF05377.11 ADV24581.1 - 1.5 9.3 21.0 0.23 11.9 5.3 3.4 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) ApoO PF09769.9 ADV24581.1 - 4.9 7.1 6.4 1.6 8.7 0.2 2.8 2 1 1 3 3 3 0 Apolipoprotein O DUF3760 PF12586.8 ADV24582.1 - 3.1e-23 81.7 9.8 1.1e-16 60.6 0.3 2.7 2 0 0 2 2 2 2 Protein of unknown function (DUF3760) Fungal_trans_2 PF11951.8 ADV24583.1 - 7.1e-10 38.2 0.0 1.2e-09 37.5 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ADV24583.1 - 2.6e-05 24.3 8.7 5.4e-05 23.2 8.7 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF3760 PF12586.8 ADV24585.1 - 9.1e-19 67.4 2.3 2.4e-18 66.0 2.3 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF3760) DUF3760 PF12586.8 ADV24586.1 - 2.9e-12 46.5 0.1 5.1e-12 45.8 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3760) DUF2326 PF10088.9 ADV24586.1 - 0.1 12.3 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein conserved in bacteria (DUF2326) DUF3760 PF12586.8 ADV24587.1 - 6.9e-16 58.2 0.9 1.5e-15 57.1 0.9 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3760) IL5 PF02025.15 ADV24587.1 - 0.14 12.5 0.0 0.26 11.6 0.0 1.4 1 0 0 1 1 1 0 Interleukin 5 Fungal_trans PF04082.18 ADV24588.1 - 1.6e-19 70.0 0.0 4.1e-19 68.6 0.0 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ADV24588.1 - 1.7e-06 28.1 10.8 3.2e-06 27.2 10.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain WD40 PF00400.32 ADV24589.1 - 4.1e-42 141.4 19.4 9.3e-08 32.6 0.1 7.8 7 1 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV24589.1 - 1.6e-17 63.6 0.5 0.00099 19.4 0.0 5.8 4 3 3 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 ADV24589.1 - 4.7e-06 26.4 1.0 0.17 11.9 0.0 3.4 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 ADV24589.1 - 5.7e-06 25.5 0.0 2.4 7.0 0.0 4.5 3 1 1 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein IKI3 PF04762.12 ADV24589.1 - 1.1 7.2 2.4 15 3.4 0.3 3.1 4 0 0 4 4 4 0 IKI3 family Sel1 PF08238.12 ADV24590.1 - 4.3e-22 78.1 23.9 7.8e-05 23.2 0.0 8.1 8 0 0 8 8 8 5 Sel1 repeat TPR_16 PF13432.6 ADV24590.1 - 0.0011 19.5 14.8 0.0084 16.7 2.1 5.2 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 ADV24590.1 - 0.006 16.8 5.6 2.6 8.4 0.0 5.2 4 2 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 ADV24590.1 - 0.0071 16.0 4.0 0.036 13.8 0.2 3.5 4 0 0 4 4 4 1 TPR repeat TPR_1 PF00515.28 ADV24590.1 - 0.04 13.7 9.9 2.4 8.1 0.0 5.5 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.17 ADV24590.1 - 3.3 8.1 0.0 3.3 8.1 0.0 5.7 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_19 PF14559.6 ADV24590.1 - 4.7 7.8 6.9 3.2 8.3 2.0 3.1 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 ADV24590.1 - 5.5 7.5 5.0 21 5.6 0.0 4.3 6 0 0 6 6 6 0 Tetratricopeptide repeat AAA PF00004.29 ADV24591.1 - 8.8e-44 149.1 0.0 1.6e-43 148.3 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ADV24591.1 - 5.7e-15 54.9 0.2 1.3e-14 53.7 0.2 1.6 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 ADV24591.1 - 1.4e-10 41.0 1.0 2.1e-10 40.4 0.1 1.8 2 0 0 2 2 1 1 Proteasomal ATPase OB C-terminal domain AAA_16 PF13191.6 ADV24591.1 - 2.7e-08 34.4 0.0 4.9e-05 23.8 0.0 2.6 2 1 1 3 3 2 2 AAA ATPase domain AAA_5 PF07728.14 ADV24591.1 - 2e-07 31.1 0.1 2.8e-06 27.4 0.1 2.7 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 ADV24591.1 - 1.7e-06 28.2 0.0 5.7e-06 26.6 0.0 1.8 2 0 0 2 2 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 ADV24591.1 - 6.2e-06 26.1 0.0 1.3e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 ADV24591.1 - 4.2e-05 23.8 0.2 0.008 16.5 0.0 2.4 1 1 1 2 2 2 1 AAA domain DUF815 PF05673.13 ADV24591.1 - 0.0011 18.2 0.0 0.0029 16.8 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_18 PF13238.6 ADV24591.1 - 0.0011 19.5 0.0 0.011 16.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 ADV24591.1 - 0.0015 18.3 0.1 0.037 13.8 0.0 2.7 3 0 0 3 3 3 1 AAA domain TIP49 PF06068.13 ADV24591.1 - 0.0024 17.2 0.3 0.0056 15.9 0.0 1.7 2 0 0 2 2 2 1 TIP49 P-loop domain Mg_chelatase PF01078.21 ADV24591.1 - 0.0034 16.8 0.0 0.0066 15.9 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI TsaE PF02367.17 ADV24591.1 - 0.0041 17.1 0.0 0.0074 16.3 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 ADV24591.1 - 0.0045 17.1 0.0 0.0096 16.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 ADV24591.1 - 0.0045 17.0 0.0 0.011 15.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 ADV24591.1 - 0.0046 16.5 0.0 0.0088 15.6 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region IstB_IS21 PF01695.17 ADV24591.1 - 0.0056 16.4 0.0 0.011 15.5 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein RNA_helicase PF00910.22 ADV24591.1 - 0.0061 16.9 0.0 0.013 15.9 0.0 1.5 1 0 0 1 1 1 1 RNA helicase ATPase PF06745.13 ADV24591.1 - 0.016 14.5 0.6 0.3 10.4 0.0 2.7 2 1 1 3 3 3 0 KaiC AAA_3 PF07726.11 ADV24591.1 - 0.017 14.9 0.0 0.036 13.9 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 ADV24591.1 - 0.021 15.1 0.0 0.04 14.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 ADV24591.1 - 0.024 14.1 0.0 0.045 13.2 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein AAA_30 PF13604.6 ADV24591.1 - 0.039 13.7 0.0 0.087 12.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 ADV24591.1 - 0.045 13.3 0.3 0.15 11.6 0.1 1.9 2 0 0 2 2 1 0 AAA domain Sigma54_activat PF00158.26 ADV24591.1 - 0.047 13.4 0.0 0.13 11.9 0.0 1.9 1 1 0 1 1 1 0 Sigma-54 interaction domain NACHT PF05729.12 ADV24591.1 - 0.059 13.3 0.0 0.19 11.6 0.0 1.8 1 1 1 2 2 2 0 NACHT domain AAA_19 PF13245.6 ADV24591.1 - 0.067 13.5 0.0 0.25 11.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain Parvo_NS1 PF01057.17 ADV24591.1 - 0.082 12.0 0.0 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_11 PF13086.6 ADV24591.1 - 0.089 12.6 0.2 0.28 10.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 ADV24591.1 - 0.12 12.3 0.0 0.5 10.2 0.0 2.1 2 1 0 2 2 1 0 ATPase domain predominantly from Archaea Prot_ATP_OB_N PF17758.1 ADV24591.1 - 0.13 11.9 0.1 0.55 9.9 0.0 2.0 2 0 0 2 2 2 0 Proteasomal ATPase OB N-terminal domain IR1-M PF12185.8 ADV24591.1 - 0.2 11.6 0.1 0.42 10.6 0.1 1.5 1 0 0 1 1 1 0 Nup358/RanBP2 E3 ligase domain Peptidase_S10 PF00450.22 ADV24592.1 - 0.0087 15.5 0.0 0.013 14.9 0.0 1.2 1 0 0 1 1 1 1 Serine carboxypeptidase Peptidase_S10 PF00450.22 ADV24593.1 - 5.3e-06 26.1 0.0 5.8e-06 26.0 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase LtrA PF06772.11 ADV24594.1 - 2.1e-37 129.2 24.6 3.1e-37 128.6 24.6 1.2 1 0 0 1 1 1 1 Bacterial low temperature requirement A protein (LtrA) DUF3995 PF13160.6 ADV24594.1 - 0.0011 19.3 1.4 0.0011 19.3 1.4 2.9 3 0 0 3 3 3 1 Protein of unknown function (DUF3995) LSM PF01423.22 ADV24595.1 - 1.5e-14 53.4 0.1 1.6e-14 53.3 0.1 1.1 1 0 0 1 1 1 1 LSM domain DUF3605 PF12239.8 ADV24597.1 - 1.4e-24 87.2 0.2 1.2e-07 32.2 0.0 3.2 3 0 0 3 3 3 3 Protein of unknown function (DUF3605) RNA_polI_A34 PF08208.11 ADV24597.1 - 1.6 8.8 10.8 0.22 11.6 3.6 2.2 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 SR-25 PF10500.9 ADV24597.1 - 1.6 8.3 11.8 0.1 12.2 3.3 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Ferritin_2 PF13668.6 ADV24598.1 - 2.1e-15 57.1 0.1 3.3e-15 56.5 0.1 1.3 1 0 0 1 1 1 1 Ferritin-like domain Ferritin-like PF12902.7 ADV24598.1 - 0.031 14.1 0.0 0.083 12.8 0.0 1.6 1 0 0 1 1 1 0 Ferritin-like DsrC PF04358.13 ADV24598.1 - 0.061 13.8 0.0 0.15 12.6 0.0 1.6 1 0 0 1 1 1 0 DsrC like protein DUF5039 PF16442.5 ADV24598.1 - 0.083 12.4 0.0 0.23 11.0 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF5039) DnaJ_C PF01556.18 ADV24599.1 - 1.6e-27 96.4 0.0 2.3e-27 95.9 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 ADV24599.1 - 6e-25 87.1 1.8 9.3e-25 86.5 1.8 1.3 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 ADV24599.1 - 1.1e-14 54.6 17.1 2e-14 53.7 17.1 1.5 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 ADV24599.1 - 0.00035 20.5 6.9 0.061 13.3 1.4 2.5 2 0 0 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 ADV24599.1 - 0.00046 20.2 5.8 0.037 14.1 0.2 2.4 2 0 0 2 2 2 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-RING_10 PF16685.5 ADV24599.1 - 0.078 13.1 0.3 0.078 13.1 0.3 2.1 2 0 0 2 2 2 0 zinc RING finger of MSL2 NUMOD3 PF07460.11 ADV24599.1 - 0.14 12.4 0.1 0.44 10.8 0.0 1.9 2 0 0 2 2 1 0 NUMOD3 motif (2 copies) DZR PF12773.7 ADV24599.1 - 0.18 11.8 10.2 0.33 11.0 10.2 1.4 1 0 0 1 1 1 0 Double zinc ribbon TackOD1 PF18551.1 ADV24599.1 - 1.1 8.9 13.8 0.13 11.9 2.8 2.3 1 1 1 2 2 2 0 Thaumarchaeal output domain 1 Lar_restr_allev PF14354.6 ADV24599.1 - 1.5 9.2 10.6 1.3 9.4 6.6 3.0 1 1 1 2 2 2 0 Restriction alleviation protein Lar A2L_zn_ribbon PF08792.10 ADV24599.1 - 4.3 7.2 16.9 4 7.3 0.1 3.2 3 1 0 3 3 3 0 A2L zinc ribbon domain LPAM_1 PF08139.12 ADV24599.1 - 5.9 7.6 5.4 11 6.7 5.4 1.4 1 0 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site DUF35_N PF12172.8 ADV24599.1 - 9.1 6.3 12.1 0.63 10.0 0.2 3.8 4 0 0 4 4 4 0 Rubredoxin-like zinc ribbon domain (DUF35_N) HABP4_PAI-RBP1 PF04774.15 ADV24600.1 - 0.0002 22.2 2.2 0.00035 21.4 2.2 1.3 1 0 0 1 1 1 1 Hyaluronan / mRNA binding family CFTR_R PF14396.6 ADV24600.1 - 0.15 11.6 0.0 0.22 11.1 0.0 1.2 1 0 0 1 1 1 0 Cystic fibrosis TM conductance regulator (CFTR), regulator domain RRM_1 PF00076.22 ADV24601.1 - 4.6e-30 103.3 0.0 4.3e-14 52.1 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Cofilin_ADF PF00241.20 ADV24602.1 - 3.3e-20 72.1 0.0 3.7e-20 71.9 0.0 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Med14 PF08638.11 ADV24604.1 - 3.9e-29 101.4 0.0 7.4e-22 77.7 0.0 2.8 3 0 0 3 3 3 2 Mediator complex subunit MED14 SRP68 PF16969.5 ADV24605.1 - 7.9e-69 233.1 5.7 2.4e-67 228.2 0.7 2.2 1 1 1 2 2 2 2 RNA-binding signal recognition particle 68 14-3-3 PF00244.20 ADV24606.1 - 4.9e-107 356.5 4.6 5.8e-107 356.3 4.6 1.0 1 0 0 1 1 1 1 14-3-3 protein DUF4253 PF14062.6 ADV24606.1 - 0.091 12.9 0.0 0.26 11.4 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4253) TPR_19 PF14559.6 ADV24606.1 - 0.46 11.0 3.1 0.62 10.6 0.1 2.6 4 0 0 4 4 4 0 Tetratricopeptide repeat Peptidase_C48 PF02902.19 ADV24607.1 - 2.6e-32 112.4 0.0 4.3e-32 111.7 0.0 1.3 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain DUF3094 PF11293.8 ADV24607.1 - 0.064 13.0 0.1 0.11 12.2 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3094) Band_7 PF01145.25 ADV24608.1 - 5.1e-23 82.0 2.5 7.4e-23 81.5 2.5 1.2 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 ADV24608.1 - 0.0014 18.4 0.2 0.0022 17.8 0.2 1.4 1 0 0 1 1 1 1 SPFH domain-Band 7 family DivIVA PF05103.13 ADV24608.1 - 0.42 10.7 2.7 0.74 9.9 2.7 1.3 1 0 0 1 1 1 0 DivIVA protein Mito_carr PF00153.27 ADV24609.1 - 1.1e-05 25.2 0.1 0.00088 19.2 0.0 2.5 2 0 0 2 2 2 1 Mitochondrial carrier protein Cyd_oper_YbgE PF09600.10 ADV24609.1 - 0.055 13.8 0.2 0.055 13.8 0.2 2.0 2 0 0 2 2 2 0 Cyd operon protein YbgE (Cyd_oper_YbgE) DUF3805 PF12712.7 ADV24609.1 - 0.095 12.9 0.0 0.23 11.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3805) TPR_1 PF00515.28 ADV24611.1 - 4e-16 58.1 0.2 2.5e-05 23.9 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 ADV24611.1 - 6.2e-15 54.0 0.6 0.00073 19.5 0.0 3.8 4 0 0 4 4 4 3 Tetratricopeptide repeat RPAP3_C PF13877.6 ADV24611.1 - 2.2e-09 37.7 0.0 4.6e-09 36.7 0.0 1.5 1 0 0 1 1 1 1 Potential Monad-binding region of RPAP3 TPR_11 PF13414.6 ADV24611.1 - 6.9e-09 35.3 0.2 3.9e-07 29.6 0.0 2.9 2 1 1 3 3 3 1 TPR repeat TPR_8 PF13181.6 ADV24611.1 - 7.4e-07 28.9 0.5 0.012 15.8 0.1 3.3 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 ADV24611.1 - 1.3e-05 25.7 0.0 0.0014 19.2 0.0 2.7 1 1 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 ADV24611.1 - 5.3e-05 23.3 2.2 0.0002 21.5 0.2 3.0 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 ADV24611.1 - 6.6e-05 22.7 0.0 0.78 9.9 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 ADV24611.1 - 0.00016 21.7 0.0 0.07 13.3 0.0 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 ADV24611.1 - 0.0031 18.0 0.0 0.062 13.8 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 ADV24611.1 - 0.004 17.4 0.4 0.18 12.1 0.5 2.6 1 1 1 2 2 2 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ADV24611.1 - 0.063 13.5 0.1 0.22 11.8 0.0 1.8 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 ADV24611.1 - 0.18 12.5 0.7 1.4 9.7 0.2 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat FAM104 PF15434.6 ADV24611.1 - 0.2 12.2 3.3 0.5 10.9 3.3 1.7 1 0 0 1 1 1 0 Family 104 Histone PF00125.24 ADV24612.1 - 1.9e-18 67.1 0.0 2.4e-18 66.7 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 ADV24612.1 - 1.2e-11 44.1 0.4 2.8e-11 43.0 0.4 1.6 1 0 0 1 1 1 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.23 ADV24612.1 - 0.0001 22.5 0.0 0.00015 22.0 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone WD40 PF00400.32 ADV24613.1 - 3.7e-24 84.5 11.7 9e-07 29.5 0.4 6.3 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV24613.1 - 6.1e-15 55.3 0.7 1.2e-05 25.5 0.0 5.2 3 2 2 6 6 5 4 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 ADV24613.1 - 0.00052 19.9 0.1 2 8.5 0.0 3.4 3 0 0 3 3 3 2 WD40-like Beta Propeller Repeat PQQ_3 PF13570.6 ADV24613.1 - 0.00099 19.5 0.1 12 6.6 0.0 4.3 4 0 0 4 4 4 1 PQQ-like domain eIF2A PF08662.11 ADV24613.1 - 0.0015 18.5 0.0 0.56 10.1 0.0 3.0 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A BBS2_Mid PF14783.6 ADV24613.1 - 0.012 15.7 0.0 0.25 11.4 0.0 2.5 2 1 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region IKI3 PF04762.12 ADV24613.1 - 0.078 11.0 0.1 0.26 9.2 0.0 1.7 2 0 0 2 2 2 0 IKI3 family Cadherin_5 PF17892.1 ADV24613.1 - 0.091 12.7 0.1 0.21 11.6 0.1 1.6 1 0 0 1 1 1 0 Cadherin-like domain Proteasome_A_N PF10584.9 ADV24613.1 - 0.12 12.1 0.8 14 5.4 0.0 2.8 2 0 0 2 2 2 0 Proteasome subunit A N-terminal signature Ge1_WD40 PF16529.5 ADV24613.1 - 0.13 11.1 0.1 4.5 6.1 0.0 2.7 3 0 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein BBS2_N PF14781.6 ADV24613.1 - 0.14 12.1 0.1 1.9 8.4 0.0 2.6 2 1 0 2 2 2 0 Ciliary BBSome complex subunit 2, N-terminal CHASE5 PF17149.4 ADV24613.1 - 0.17 11.9 0.5 4.8 7.2 0.2 2.4 1 1 1 2 2 2 0 Periplasmic sensor domain found in signal transduction proteins VID27 PF08553.10 ADV24613.1 - 0.2 10.7 0.0 1.7 7.6 0.0 1.9 2 0 0 2 2 2 0 VID27 C-terminal WD40-like domain MTS PF05175.14 ADV24614.1 - 0.0002 20.9 0.6 2.1 7.9 0.0 3.1 2 1 1 3 3 3 3 Methyltransferase small domain DUF1269 PF06897.12 ADV24614.1 - 0.097 13.0 0.0 1.3 9.4 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1269) PCMT PF01135.19 ADV24614.1 - 0.19 11.5 0.0 0.84 9.3 0.0 1.8 2 0 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) BSD PF03909.17 ADV24615.1 - 1.4e-09 37.8 0.0 5.9e-09 35.8 0.0 2.1 1 0 0 1 1 1 1 BSD domain DUF883 PF05957.13 ADV24615.1 - 0.028 15.0 1.5 1.3 9.7 0.1 3.0 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) RapH_N PF18801.1 ADV24615.1 - 0.11 12.6 0.2 0.43 10.7 0.0 2.1 2 0 0 2 2 2 0 response regulator aspartate phosphatase H, N terminal Frankia_peptide PF14407.6 ADV24615.1 - 0.27 11.3 3.5 0.48 10.4 0.1 3.2 4 0 0 4 4 4 0 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. WES_acyltransf PF03007.16 ADV24615.1 - 0.53 10.0 3.2 0.31 10.8 0.4 1.9 2 0 0 2 2 2 0 Wax ester synthase-like Acyl-CoA acyltransferase domain IPK PF03770.16 ADV24616.1 - 0.094 12.6 0.0 0.13 12.1 0.0 1.2 1 0 0 1 1 1 0 Inositol polyphosphate kinase RNB PF00773.19 ADV24618.1 - 1.4e-93 313.8 0.0 2.1e-93 313.2 0.0 1.2 1 0 0 1 1 1 1 RNB domain Rrp44_CSD1 PF17216.3 ADV24618.1 - 9.5e-26 90.3 0.0 2.3e-25 89.0 0.0 1.6 1 0 0 1 1 1 1 Rrp44-like cold shock domain Rrp44_S1 PF17215.3 ADV24618.1 - 9e-23 80.1 0.2 2.3e-22 78.8 0.2 1.7 1 0 0 1 1 1 1 S1 domain OB_Dis3 PF17849.1 ADV24618.1 - 8.7e-15 54.5 0.0 2.3e-14 53.2 0.0 1.8 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) PIN_4 PF13638.6 ADV24618.1 - 4e-14 53.0 0.2 1.2e-13 51.5 0.2 1.9 1 0 0 1 1 1 1 PIN domain CSD2 PF17876.1 ADV24618.1 - 7.1e-06 26.1 0.6 0.007 16.5 0.0 3.7 3 0 0 3 3 3 1 Cold shock domain OB_RNB PF08206.11 ADV24618.1 - 0.15 11.8 1.0 0.45 10.2 0.0 2.3 2 0 0 2 2 2 0 Ribonuclease B OB domain Cellulase PF00150.18 ADV24619.1 - 1.7e-13 50.7 0.6 2.1e-13 50.4 0.1 1.5 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) DUF4930 PF16284.5 ADV24620.1 - 0.015 15.3 0.3 0.039 13.9 0.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4930) NAD_binding_10 PF13460.6 ADV24621.1 - 3.5e-30 105.3 0.1 4.4e-30 104.9 0.1 1.1 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 ADV24621.1 - 3.8e-08 33.1 0.0 7.7e-08 32.1 0.0 1.4 1 1 1 2 2 2 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 ADV24621.1 - 1.6e-05 24.6 0.0 2.3e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_4 PF07993.12 ADV24621.1 - 0.00041 19.6 0.0 0.0005 19.3 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein LpxI_N PF17930.1 ADV24621.1 - 0.017 15.0 0.2 7.5 6.5 0.0 2.3 1 1 0 2 2 2 0 LpxI N-terminal domain RmlD_sub_bind PF04321.17 ADV24621.1 - 0.018 14.2 0.0 0.028 13.5 0.0 1.4 1 1 0 1 1 1 0 RmlD substrate binding domain Glyco_trans_4_2 PF13477.6 ADV24621.1 - 0.049 13.7 0.0 0.099 12.7 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase 4-like Cid2 PF09774.9 ADV24622.1 - 2.9e-24 86.3 0.2 3.1e-15 57.0 0.0 2.1 1 1 1 2 2 2 2 Caffeine-induced death protein 2 WD40 PF00400.32 ADV24623.1 - 2.9e-07 31.1 8.3 0.2 12.6 0.1 7.0 8 0 0 8 8 8 4 WD domain, G-beta repeat RSN1_7TM PF02714.15 ADV24624.1 - 1.4e-80 270.6 26.1 2.1e-80 270.0 26.1 1.3 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 ADV24624.1 - 1.4e-31 110.1 0.0 2.5e-31 109.3 0.0 1.4 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter RSN1_TM PF13967.6 ADV24624.1 - 2.2e-30 105.5 1.0 2.2e-30 105.5 1.0 3.0 4 0 0 4 4 4 1 Late exocytosis, associated with Golgi transport GST_N_3 PF13417.6 ADV24625.1 - 1.7e-11 44.4 0.1 2.7e-11 43.7 0.1 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 ADV24625.1 - 6e-08 32.9 0.0 1.1e-07 32.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 ADV24625.1 - 3.2e-07 30.5 0.1 6.2e-07 29.6 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain ADH_zinc_N_2 PF13602.6 ADV24625.1 - 0.036 15.1 0.1 0.074 14.1 0.0 1.5 2 0 0 2 2 2 0 Zinc-binding dehydrogenase Nepo_coat_N PF03689.15 ADV24625.1 - 0.075 13.0 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 Nepovirus coat protein, N-terminal domain LEA_3 PF03242.13 ADV24625.1 - 0.087 13.6 0.0 0.19 12.5 0.0 1.6 1 0 0 1 1 1 0 Late embryogenesis abundant protein DEAD PF00270.29 ADV24626.1 - 1.9e-09 37.5 0.0 4.1e-09 36.4 0.0 1.7 1 1 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 ADV24626.1 - 0.085 12.9 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Glycos_transf_1 PF00534.20 ADV24629.1 - 5.9e-24 84.5 0.0 1.7e-23 83.0 0.0 1.7 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 ADV24629.1 - 7.4e-12 45.6 0.0 2.5e-11 43.9 0.0 1.8 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.6 ADV24629.1 - 1.5e-10 41.6 0.0 4.3e-10 40.2 0.0 1.7 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 ADV24629.1 - 2e-05 25.1 0.0 4e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.6 ADV24629.1 - 0.033 14.6 0.0 0.077 13.4 0.0 1.6 1 0 0 1 1 1 0 Glycosyl transferases group 1 Peptidase_C48 PF02902.19 ADV24630.1 - 1.8e-29 103.1 0.0 6.2e-17 62.2 0.0 2.6 2 0 0 2 2 2 2 Ulp1 protease family, C-terminal catalytic domain Arginosuc_synth PF00764.19 ADV24631.1 - 1.5e-156 521.6 0.0 1.7e-156 521.4 0.0 1.0 1 0 0 1 1 1 1 Arginosuccinate synthase QueC PF06508.13 ADV24631.1 - 0.00027 20.5 0.0 0.00042 19.9 0.0 1.2 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.16 ADV24631.1 - 0.0059 15.4 0.0 0.0097 14.7 0.0 1.4 1 0 0 1 1 1 1 tRNA methyl transferase Sybindin PF04099.12 ADV24632.1 - 4.1e-10 39.7 0.0 5.5e-10 39.3 0.0 1.1 1 0 0 1 1 1 1 Sybindin-like family CPDase PF07823.11 ADV24633.1 - 2.9e-39 134.8 0.0 3.6e-39 134.5 0.0 1.0 1 0 0 1 1 1 1 Cyclic phosphodiesterase-like protein 2_5_RNA_ligase2 PF13563.6 ADV24633.1 - 9.3e-06 25.6 0.0 1.3e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily NUDE_C PF04880.13 ADV24633.1 - 0.24 11.9 1.6 0.34 11.4 0.4 1.7 2 0 0 2 2 2 0 NUDE protein, C-terminal conserved region Amidohydro_1 PF01979.20 ADV24634.1 - 5.7e-29 101.5 0.0 6.9e-29 101.2 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 ADV24634.1 - 1.1e-12 48.2 0.2 6e-08 32.6 0.0 2.1 2 0 0 2 2 2 2 Amidohydrolase family Peptidase_M24 PF00557.24 ADV24635.1 - 2.1e-14 53.7 0.0 2.7e-14 53.4 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 DUF676 PF05057.14 ADV24636.1 - 3.3e-32 111.8 0.0 5e-32 111.2 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Palm_thioest PF02089.15 ADV24636.1 - 0.021 14.7 0.0 0.028 14.2 0.0 1.3 1 0 0 1 1 1 0 Palmitoyl protein thioesterase Lipase_3 PF01764.25 ADV24636.1 - 0.024 14.5 0.0 0.039 13.8 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) PGAP1 PF07819.13 ADV24636.1 - 0.18 11.5 0.1 1.4 8.5 0.1 2.1 1 1 0 1 1 1 0 PGAP1-like protein DnaJ PF00226.31 ADV24637.1 - 1e-12 48.0 0.2 1.7e-12 47.3 0.2 1.4 1 0 0 1 1 1 1 DnaJ domain Pep1_7 PF17232.2 ADV24638.1 - 0.081 13.4 0.7 0.32 11.5 0.1 2.2 3 0 0 3 3 3 0 Elicitor peptide 1-7 Pkinase PF00069.25 ADV24641.1 - 1.7e-72 243.9 0.0 2.2e-72 243.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV24641.1 - 3.7e-38 131.3 0.0 4.9e-38 130.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 ADV24641.1 - 5.9e-15 55.4 0.0 1.2e-14 54.3 0.0 1.6 1 0 0 1 1 1 1 FHA domain Kinase-like PF14531.6 ADV24641.1 - 1.6e-10 40.8 0.0 9.4e-09 35.0 0.0 2.1 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 ADV24641.1 - 8.9e-06 25.8 0.2 0.0011 18.9 0.0 2.4 2 1 1 3 3 3 2 Phosphotransferase enzyme family Yop-YscD_cpl PF16697.5 ADV24641.1 - 2e-05 24.8 0.0 0.0011 19.3 0.0 2.4 1 1 1 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain Kdo PF06293.14 ADV24641.1 - 2.4e-05 23.8 0.1 4.3e-05 23.0 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 ADV24641.1 - 0.004 16.0 0.0 0.0074 15.1 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase CAP_N PF01213.19 ADV24642.1 - 7.6e-81 272.0 0.4 1.4e-80 271.2 0.4 1.4 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal CAP_C PF08603.11 ADV24642.1 - 1.3e-59 200.3 11.5 1.8e-59 199.9 11.5 1.2 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TBCC PF07986.12 ADV24642.1 - 0.4 10.4 8.0 0.66 9.7 8.0 1.3 1 0 0 1 1 1 0 Tubulin binding cofactor C PI3_PI4_kinase PF00454.27 ADV24643.1 - 4e-44 151.3 0.0 7.4e-44 150.4 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.23 ADV24643.1 - 8.8e-39 133.7 4.6 8.8e-39 133.7 4.6 2.0 2 0 0 2 2 2 1 FAT domain FRB_dom PF08771.11 ADV24643.1 - 6.1e-14 52.2 0.0 2.3e-13 50.4 0.0 2.1 1 0 0 1 1 1 1 FKBP12-rapamycin binding domain FATC PF02260.20 ADV24643.1 - 9.1e-12 44.6 0.1 1.9e-11 43.5 0.1 1.6 1 0 0 1 1 1 1 FATC domain HD_assoc PF13286.6 ADV24643.1 - 0.031 14.8 0.1 0.23 12.0 0.0 2.5 2 0 0 2 2 2 0 Phosphohydrolase-associated domain ART PF01129.18 ADV24643.1 - 0.086 12.1 0.0 0.18 11.1 0.0 1.4 1 0 0 1 1 1 0 NAD:arginine ADP-ribosyltransferase P22_AR_C PF10548.9 ADV24643.1 - 0.12 12.5 0.1 1.7 8.9 0.1 2.9 2 0 0 2 2 2 0 P22AR C-terminal domain zf-C2H2 PF00096.26 ADV24644.1 - 1.2e-08 34.9 11.6 0.00055 20.2 1.1 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ADV24644.1 - 1.1e-05 25.9 8.9 0.0087 16.8 2.3 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ADV24644.1 - 1.2e-05 25.5 11.9 0.0034 17.7 2.6 3.7 3 0 0 3 3 3 2 Zinc-finger double domain zf-met PF12874.7 ADV24644.1 - 0.009 16.4 3.0 1.1 9.7 0.3 2.8 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-Di19 PF05605.12 ADV24644.1 - 0.013 15.8 3.4 0.58 10.5 0.3 2.5 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Rad50_zn_hook PF04423.14 ADV24644.1 - 0.17 11.8 0.0 0.3 11.0 0.0 1.4 1 0 0 1 1 1 0 Rad50 zinc hook motif zf-H2C2_5 PF13909.6 ADV24644.1 - 4 7.3 8.4 2.5 8.0 0.3 2.7 2 0 0 2 2 2 0 C2H2-type zinc-finger domain G10 PF01125.17 ADV24645.1 - 4.5e-68 227.6 5.2 5.1e-68 227.4 5.2 1.0 1 0 0 1 1 1 1 G10 protein ATP_transf PF09830.9 ADV24646.1 - 5.9e-16 58.4 0.0 1.3e-15 57.3 0.0 1.6 1 0 0 1 1 1 1 ATP adenylyltransferase Sas10_Utp3 PF04000.15 ADV24647.1 - 4.2e-10 40.1 0.0 7.9e-10 39.2 0.0 1.5 1 0 0 1 1 1 1 Sas10/Utp3/C1D family CDV3 PF15359.6 ADV24647.1 - 0.1 13.1 0.9 0.21 12.1 0.9 1.5 1 0 0 1 1 1 0 Carnitine deficiency-associated protein 3 SMK-1 PF04802.15 ADV24648.1 - 3.4e-70 235.8 0.0 9.5e-70 234.3 0.0 1.7 1 0 0 1 1 1 1 Component of IIS longevity pathway SMK-1 YL1 PF05764.13 ADV24648.1 - 8e-05 22.9 11.0 8e-05 22.9 11.0 1.7 2 0 0 2 2 2 1 YL1 nuclear protein Ribosomal_L2_C PF03947.18 ADV24649.1 - 8.5e-47 158.5 4.5 1.3e-46 157.9 4.5 1.3 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 ADV24649.1 - 1.9e-14 53.4 0.0 5.3e-14 51.9 0.0 1.8 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain EST1_DNA_bind PF10373.9 ADV24650.1 - 3.3e-31 108.8 0.0 6.9e-31 107.8 0.0 1.5 1 0 0 1 1 1 1 Est1 DNA/RNA binding domain EST1 PF10374.9 ADV24650.1 - 5.4e-22 78.9 0.0 1e-20 74.8 0.0 2.6 2 1 0 2 2 2 1 Telomerase activating protein Est1 TPR_19 PF14559.6 ADV24650.1 - 1.6 9.3 5.0 41 4.8 0.1 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat Tim54 PF11711.8 ADV24651.1 - 5.3e-39 134.1 0.0 8.8e-39 133.3 0.0 1.4 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 DUF2408 PF10303.9 ADV24652.1 - 2e-57 193.5 0.1 4.8e-39 134.0 0.0 4.4 4 1 0 4 4 4 4 Protein of unknown function (DUF2408) ATG16 PF08614.11 ADV24652.1 - 0.0062 16.8 0.1 0.53 10.5 0.0 2.9 2 1 1 3 3 3 1 Autophagy protein 16 (ATG16) Metal_resist PF13801.6 ADV24652.1 - 0.073 13.3 0.1 0.23 11.7 0.1 1.8 1 0 0 1 1 1 0 Heavy-metal resistance DUF3336 PF11815.8 ADV24652.1 - 0.18 11.5 0.3 0.77 9.5 0.0 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF3336) DUF262 PF03235.14 ADV24653.1 - 2.8e-14 53.8 0.0 1.1e-13 51.9 0.0 1.8 1 1 0 1 1 1 1 Protein of unknown function DUF262 Peroxin-13_N PF04088.13 ADV24653.1 - 0.021 15.1 0.2 0.037 14.3 0.2 1.4 1 0 0 1 1 1 0 Peroxin 13, N-terminal region PGI PF00342.19 ADV24653.1 - 0.16 10.5 0.0 0.26 9.8 0.0 1.4 1 0 0 1 1 1 0 Phosphoglucose isomerase DUF2340 PF10209.9 ADV24655.1 - 2.7e-47 160.1 0.2 3.3e-47 159.8 0.2 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2340) LSM PF01423.22 ADV24656.1 - 1.8e-20 72.3 0.0 2.2e-20 72.1 0.0 1.1 1 0 0 1 1 1 1 LSM domain FGGY_N PF00370.21 ADV24657.1 - 5.7e-13 49.0 0.0 5.3e-08 32.7 0.0 2.3 1 1 0 2 2 2 2 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 ADV24657.1 - 6.9e-11 42.2 0.0 1.5e-10 41.2 0.0 1.6 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain TMCO5 PF14992.6 ADV24658.1 - 0.045 13.3 0.0 0.49 9.9 0.0 1.9 1 1 1 2 2 2 0 TMCO5 family CCDC53 PF10152.9 ADV24658.1 - 0.053 13.9 0.1 0.071 13.5 0.1 1.3 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex DUF3961 PF13106.6 ADV24658.1 - 0.15 11.7 0.1 0.22 11.2 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3961) DAG1 PF05454.11 ADV24658.1 - 0.5 9.7 3.0 0.58 9.5 1.7 1.7 1 1 1 2 2 2 0 Dystroglycan (Dystrophin-associated glycoprotein 1) Acyltransferase PF01553.21 ADV24659.1 - 1.1e-32 112.4 0.0 1.6e-32 111.9 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase FANCF PF11107.8 ADV24659.1 - 0.012 14.9 0.0 0.019 14.2 0.0 1.2 1 0 0 1 1 1 0 Fanconi anemia group F protein (FANCF) Adaptin_N PF01602.20 ADV24660.1 - 2.7e-135 451.9 0.0 4e-135 451.4 0.0 1.2 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 ADV24660.1 - 3.4e-54 183.3 0.1 1.9e-51 174.4 0.0 3.0 2 2 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 ADV24660.1 - 6.8e-19 68.0 7.0 8.8e-07 29.2 0.0 6.9 3 2 2 6 6 6 4 HEAT repeats HEAT PF02985.22 ADV24660.1 - 1.5e-09 37.3 8.7 0.0077 16.4 0.1 7.2 8 0 0 8 8 8 2 HEAT repeat Arm PF00514.23 ADV24660.1 - 4.5e-07 29.7 2.1 0.0026 17.7 0.0 5.3 5 0 0 5 5 5 1 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 ADV24660.1 - 5.2e-05 23.7 0.9 8.2 7.1 0.1 6.2 5 1 1 6 6 6 1 HEAT-like repeat Cnd3 PF12719.7 ADV24660.1 - 0.00055 19.2 0.0 0.8 8.8 0.0 2.4 2 0 0 2 2 2 2 Nuclear condensing complex subunits, C-term domain CLASP_N PF12348.8 ADV24660.1 - 0.0019 17.8 0.1 0.15 11.6 0.0 3.3 3 1 0 3 3 3 1 CLASP N terminal RTP1_C1 PF10363.9 ADV24660.1 - 0.023 14.9 2.1 5.5 7.2 0.0 4.4 2 1 2 5 5 5 0 Required for nuclear transport of RNA pol II C-terminus 1 Sec7_N PF12783.7 ADV24660.1 - 0.038 13.9 0.2 0.14 12.1 0.2 1.9 1 0 0 1 1 1 0 Guanine nucleotide exchange factor in Golgi transport N-terminal PAPS_reduct PF01507.19 ADV24661.1 - 7.7e-20 71.6 0.3 3.2e-15 56.6 0.1 2.1 2 0 0 2 2 2 2 Phosphoadenosine phosphosulfate reductase family CRAL_TRIO PF00650.20 ADV24663.1 - 5.4e-17 62.0 0.0 8.4e-17 61.3 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 ADV24663.1 - 0.0074 16.4 0.0 0.015 15.4 0.0 1.5 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain UAA PF08449.11 ADV24664.1 - 2.1e-48 165.1 1.5 2.2e-47 161.7 1.5 2.1 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.20 ADV24664.1 - 2e-10 40.9 28.1 3.5e-07 30.5 6.9 4.8 5 0 0 5 5 5 3 EamA-like transporter family Nuc_sug_transp PF04142.15 ADV24664.1 - 1.2e-06 28.0 2.6 0.0028 16.9 0.1 2.1 2 0 0 2 2 2 2 Nucleotide-sugar transporter TPT PF03151.16 ADV24664.1 - 6e-05 22.5 2.3 0.034 13.5 0.1 2.4 2 0 0 2 2 2 2 Triose-phosphate Transporter family PUNUT PF16913.5 ADV24664.1 - 0.0067 15.7 1.5 0.0067 15.7 1.5 2.1 2 0 0 2 2 2 1 Purine nucleobase transmembrane transport TMEM234 PF10639.9 ADV24664.1 - 0.03 14.3 2.5 0.24 11.4 0.4 2.5 2 0 0 2 2 2 0 Putative transmembrane family 234 Multi_Drug_Res PF00893.19 ADV24664.1 - 7.9 7.2 9.3 79 4.0 0.1 4.1 3 1 1 4 4 4 0 Small Multidrug Resistance protein zf-C3HC4_3 PF13920.6 ADV24665.1 - 3.8e-08 33.1 5.4 5.6e-08 32.5 5.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ADV24665.1 - 4.1e-08 32.9 8.2 6.6e-08 32.3 8.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ADV24665.1 - 1.3e-06 28.2 8.3 8.7e-06 25.5 8.7 2.0 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ADV24665.1 - 1.7e-06 28.2 7.4 2.8e-06 27.5 7.4 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 ADV24665.1 - 2.3e-05 24.2 6.9 6.4e-05 22.8 7.1 1.6 1 1 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 ADV24665.1 - 8.9e-05 22.4 6.5 8.9e-05 22.4 6.5 1.7 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 ADV24665.1 - 0.004 17.3 9.5 0.0084 16.2 9.5 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 ADV24665.1 - 0.0071 16.2 5.8 0.017 15.0 5.8 1.6 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-Nse PF11789.8 ADV24665.1 - 0.036 13.9 4.0 0.08 12.8 4.0 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-MIZ PF02891.20 ADV24665.1 - 0.17 11.6 7.1 0.66 9.8 7.1 1.9 1 1 1 2 2 2 0 MIZ/SP-RING zinc finger zf-rbx1 PF12678.7 ADV24665.1 - 0.35 11.2 7.1 1 9.7 7.1 1.7 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 ADV24665.1 - 0.42 10.7 2.1 0.8 9.8 2.1 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger DUF2229 PF09989.9 ADV24665.1 - 0.46 10.1 1.7 5.7 6.5 0.7 2.5 1 1 1 2 2 2 0 CoA enzyme activase uncharacterised domain (DUF2229) Zn-ribbon_8 PF09723.10 ADV24665.1 - 1.2 9.3 4.6 5 7.3 1.1 2.5 2 0 0 2 2 2 0 Zinc ribbon domain TerY_C PF15616.6 ADV24665.1 - 2.2 8.4 4.5 5.6 7.1 4.5 1.5 1 1 0 1 1 1 0 TerY-C metal binding domain FYDLN_acid PF09538.10 ADV24665.1 - 5.1 7.8 8.8 4.8 7.9 0.0 3.5 3 0 0 3 3 3 0 Protein of unknown function (FYDLN_acid) Vfa1 PF08432.10 ADV24665.1 - 9.6 6.5 11.3 2.5 8.4 3.6 3.1 3 0 0 3 3 3 0 AAA-ATPase Vps4-associated protein 1 WD40 PF00400.32 ADV24666.1 - 9.4e-26 89.6 9.7 1.1e-06 29.3 0.4 6.3 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV24666.1 - 3.5e-09 36.8 0.1 0.00034 20.8 0.1 4.6 1 1 4 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ADV24666.1 - 5.8e-06 25.5 0.0 0.0076 15.3 0.0 3.2 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ADV24666.1 - 2.1e-05 24.3 0.4 0.08 12.9 0.1 4.3 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat eIF2A PF08662.11 ADV24666.1 - 2.5e-05 24.2 0.3 0.00097 19.1 0.2 3.1 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ADV24666.1 - 0.04 12.6 1.3 1 7.9 0.3 2.2 1 1 1 2 2 2 0 Nucleoporin Nup120/160 SKN1 PF03935.15 ADV24667.1 - 3.4e-208 692.1 6.0 4e-208 691.9 6.0 1.0 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) Condensation PF00668.20 ADV24667.1 - 0.41 9.3 0.9 0.58 8.8 0.9 1.1 1 0 0 1 1 1 0 Condensation domain PhyH PF05721.13 ADV24668.1 - 1.2e-19 71.4 0.0 1.3e-17 64.8 0.0 2.3 2 0 0 2 2 2 2 Phytanoyl-CoA dioxygenase (PhyH) Flavoprotein PF02441.19 ADV24669.1 - 3.4e-49 166.6 0.0 5e-49 166.1 0.0 1.2 1 0 0 1 1 1 1 Flavoprotein Npa1 PF11707.8 ADV24670.1 - 4.1e-59 200.6 0.0 2.1e-58 198.3 0.0 2.3 2 0 0 2 2 2 1 Ribosome 60S biogenesis N-terminal NopRA1 PF16201.5 ADV24670.1 - 1.5e-47 161.8 2.0 6e-47 159.8 2.0 2.2 1 0 0 1 1 1 1 Nucleolar pre-ribosomal-associated protein 1 DUF5327 PF17261.2 ADV24670.1 - 0.076 13.8 2.0 1.9 9.3 0.0 3.2 3 0 0 3 3 3 0 Family of unknown function (DUF5327) MFS_1 PF07690.16 ADV24671.1 - 2.4e-37 128.7 47.3 2.4e-33 115.5 46.5 2.8 2 1 0 2 2 2 2 Major Facilitator Superfamily MFS_1 PF07690.16 ADV24672.1 - 1.4e-40 139.3 51.7 2.2e-39 135.4 52.4 2.6 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 ADV24672.1 - 1.4e-12 46.9 17.7 1.4e-12 46.9 17.7 1.9 2 1 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 ADV24672.1 - 1.1e-06 27.9 17.7 1.1e-06 27.9 17.7 3.3 1 1 1 3 3 3 1 Sugar (and other) transporter PetL PF05115.14 ADV24672.1 - 0.037 14.0 5.6 0.31 11.0 0.8 3.5 2 0 0 2 2 2 0 Cytochrome B6-F complex subunit VI (PetL) Tmemb_14 PF03647.13 ADV24673.1 - 1.8e-23 83.1 10.2 2e-23 82.9 10.2 1.0 1 0 0 1 1 1 1 Transmembrane proteins 14C Methyltransf_16 PF10294.9 ADV24674.1 - 1.7e-15 57.2 0.0 3.5e-15 56.2 0.0 1.4 1 1 0 1 1 1 1 Lysine methyltransferase SAM_MT PF04445.13 ADV24674.1 - 0.0038 16.7 0.0 0.0057 16.1 0.0 1.3 1 0 0 1 1 1 1 Putative SAM-dependent methyltransferase TehB PF03848.14 ADV24674.1 - 0.014 14.9 0.0 0.026 13.9 0.0 1.4 1 0 0 1 1 1 0 Tellurite resistance protein TehB Methyltransf_23 PF13489.6 ADV24674.1 - 0.014 15.2 0.0 0.031 14.1 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_25 PF13649.6 ADV24674.1 - 0.059 14.1 0.0 0.15 12.8 0.0 1.8 2 1 0 2 2 2 0 Methyltransferase domain RrnaAD PF00398.20 ADV24674.1 - 0.071 12.2 0.0 0.12 11.4 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Methyltransf_12 PF08242.12 ADV24674.1 - 0.18 12.6 0.0 0.63 10.8 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 ADV24674.1 - 0.23 11.2 0.0 0.48 10.2 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Zip PF02535.22 ADV24675.1 - 1.3e-65 221.8 7.6 1.5e-65 221.7 7.6 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter Fasciclin PF02469.22 ADV24676.1 - 0.024 14.9 0.0 0.038 14.2 0.0 1.4 1 0 0 1 1 1 0 Fasciclin domain ABC_tran PF00005.27 ADV24677.1 - 3.1e-46 157.3 0.1 2.1e-22 80.1 0.0 3.0 3 0 0 3 3 2 2 ABC transporter ABC_tran_Xtn PF12848.7 ADV24677.1 - 1.9e-20 72.6 6.2 1.9e-20 72.6 6.2 2.8 4 0 0 4 4 3 1 ABC transporter AAA_21 PF13304.6 ADV24677.1 - 5.2e-16 59.3 4.5 0.0016 18.3 0.0 4.3 3 1 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ADV24677.1 - 1.9e-09 37.3 1.9 0.13 11.7 0.0 4.6 4 0 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 ADV24677.1 - 1e-07 32.5 0.0 0.0046 17.3 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_23 PF13476.6 ADV24677.1 - 1.3e-07 32.4 11.7 0.00028 21.5 0.0 4.0 5 0 0 5 5 3 2 AAA domain AAA_29 PF13555.6 ADV24677.1 - 1.3e-07 31.3 4.7 0.0012 18.5 0.1 3.0 3 0 0 3 3 3 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 ADV24677.1 - 1.4e-06 28.4 0.4 0.0024 17.9 0.4 3.3 3 1 0 3 3 3 1 50S ribosome-binding GTPase AAA_15 PF13175.6 ADV24677.1 - 1.7e-06 28.0 11.1 0.057 13.1 0.2 4.4 3 2 1 4 4 4 3 AAA ATPase domain NACHT PF05729.12 ADV24677.1 - 5.3e-06 26.5 0.0 0.077 12.9 0.0 2.6 2 0 0 2 2 2 2 NACHT domain RsgA_GTPase PF03193.16 ADV24677.1 - 2.8e-05 24.1 4.6 0.012 15.5 0.0 3.8 4 0 0 4 4 3 1 RsgA GTPase AAA_22 PF13401.6 ADV24677.1 - 4.4e-05 23.8 0.0 0.15 12.3 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_24 PF13479.6 ADV24677.1 - 0.00012 21.9 0.1 1 9.0 0.0 3.3 3 0 0 3 3 3 2 AAA domain Dynamin_N PF00350.23 ADV24677.1 - 0.00016 21.7 8.8 0.02 14.9 0.1 4.1 2 2 1 3 3 3 2 Dynamin family RNA_helicase PF00910.22 ADV24677.1 - 0.00033 21.0 1.8 2 8.8 0.0 3.5 3 0 0 3 3 3 1 RNA helicase NB-ARC PF00931.22 ADV24677.1 - 0.00051 19.3 0.0 0.38 9.9 0.0 2.4 2 0 0 2 2 2 2 NB-ARC domain FtsK_SpoIIIE PF01580.18 ADV24677.1 - 0.001 18.5 0.0 3.2 7.0 0.0 3.3 3 0 0 3 3 3 1 FtsK/SpoIIIE family AAA_18 PF13238.6 ADV24677.1 - 0.0013 19.2 0.0 4 8.0 0.0 3.3 3 0 0 3 3 3 1 AAA domain AAA_30 PF13604.6 ADV24677.1 - 0.0018 18.0 0.2 0.33 10.6 0.0 3.0 3 1 0 3 3 2 1 AAA domain Roc PF08477.13 ADV24677.1 - 0.0029 17.8 0.0 1.8 8.8 0.0 2.8 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_5 PF07728.14 ADV24677.1 - 0.0036 17.3 0.0 6 6.9 0.0 3.1 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 ADV24677.1 - 0.0055 16.9 0.0 2.6 8.2 0.0 3.0 3 0 0 3 3 3 1 AAA domain DUF3987 PF13148.6 ADV24677.1 - 0.0067 15.5 0.7 0.12 11.4 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF3987) FeoB_N PF02421.18 ADV24677.1 - 0.0067 16.0 0.0 0.07 12.7 0.1 2.4 2 0 0 2 2 2 1 Ferrous iron transport protein B NTPase_1 PF03266.15 ADV24677.1 - 0.0074 16.2 3.0 1.9 8.4 0.2 3.8 4 0 0 4 4 4 1 NTPase DAP3 PF10236.9 ADV24677.1 - 0.0099 15.1 1.1 11 5.1 0.0 3.3 3 0 0 3 3 3 0 Mitochondrial ribosomal death-associated protein 3 TsaE PF02367.17 ADV24677.1 - 0.01 15.9 0.1 12 5.9 0.0 3.4 2 1 1 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF87 PF01935.17 ADV24677.1 - 0.011 15.9 5.0 2.7 8.0 0.0 3.9 5 1 1 6 6 4 0 Helicase HerA, central domain AAA_28 PF13521.6 ADV24677.1 - 0.014 15.6 0.0 2.6 8.2 0.1 2.9 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 ADV24677.1 - 0.017 14.7 0.0 6 6.4 0.0 3.4 3 0 0 3 3 3 0 AAA domain ATP-synt_ab PF00006.25 ADV24677.1 - 0.018 14.7 0.4 4.4 6.9 0.0 3.1 3 1 0 3 3 3 0 ATP synthase alpha/beta family, nucleotide-binding domain Pox_A32 PF04665.12 ADV24677.1 - 0.019 14.4 2.8 3.6 7.0 0.1 3.7 3 1 0 3 3 3 0 Poxvirus A32 protein Septin PF00735.18 ADV24677.1 - 0.024 13.9 0.0 3.8 6.7 0.0 2.7 2 0 0 2 2 2 0 Septin AAA_7 PF12775.7 ADV24677.1 - 0.026 14.0 0.7 2.8 7.4 0.0 3.1 4 0 0 4 4 4 0 P-loop containing dynein motor region AAA PF00004.29 ADV24677.1 - 0.037 14.4 2.8 18 5.8 0.2 4.2 3 3 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) PRK PF00485.18 ADV24677.1 - 0.067 12.9 0.0 5.2 6.7 0.0 2.9 3 0 0 3 3 3 0 Phosphoribulokinase / Uridine kinase family MarR_2 PF12802.7 ADV24677.1 - 0.075 12.9 0.0 0.26 11.2 0.0 1.9 1 0 0 1 1 1 0 MarR family ATP_bind_1 PF03029.17 ADV24677.1 - 0.075 12.8 0.1 5.6 6.7 0.0 3.1 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein Sigma54_activat PF00158.26 ADV24677.1 - 0.084 12.6 0.0 7.6 6.2 0.0 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain MeaB PF03308.16 ADV24677.1 - 0.096 11.6 0.2 16 4.3 0.0 3.2 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB TnpV PF14198.6 ADV24677.1 - 0.18 11.8 4.5 0.31 11.0 1.9 2.3 2 0 0 2 2 2 0 Transposon-encoded protein TnpV EF-hand_1 PF00036.32 ADV24679.1 - 3.4e-31 104.5 9.4 4.7e-08 32.0 0.2 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 ADV24679.1 - 9.6e-24 83.6 6.6 7.7e-14 51.9 1.2 2.6 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 ADV24679.1 - 1.5e-23 81.2 10.5 2.4e-06 26.8 0.4 4.5 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 ADV24679.1 - 3.4e-23 79.5 7.7 1.1e-05 25.0 0.1 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 ADV24679.1 - 5.7e-15 54.9 13.7 0.00013 21.7 0.4 4.5 2 1 2 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 ADV24679.1 - 2.9e-06 27.6 0.1 0.011 16.0 0.0 2.4 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 ADV24679.1 - 5.5e-05 23.1 6.1 0.0064 16.4 0.4 3.7 1 1 3 4 4 4 1 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 ADV24679.1 - 0.00046 20.4 0.1 0.84 10.0 0.1 3.0 2 1 1 3 3 3 2 EF-hand domain Dockerin_1 PF00404.18 ADV24679.1 - 2 8.7 5.6 3.4 7.9 1.8 2.8 2 2 0 2 2 2 0 Dockerin type I domain MFS_1 PF07690.16 ADV24680.1 - 7.6e-16 58.0 31.3 2.4e-15 56.3 29.3 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily Phage_holin_2_4 PF16082.5 ADV24680.1 - 0.11 12.3 0.0 0.25 11.1 0.0 1.6 1 0 0 1 1 1 0 Bacteriophage holin family, superfamily II-like Fungal_trans_2 PF11951.8 ADV24681.1 - 3.4e-29 101.8 1.1 3.4e-29 101.8 1.1 1.8 2 1 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ADV24681.1 - 0.0031 17.6 7.8 0.0053 16.8 7.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ELFV_dehydrog PF00208.21 ADV24682.1 - 1.9e-51 175.1 0.0 3.4e-51 174.3 0.0 1.4 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Bac_GDH PF05088.12 ADV24682.1 - 1.3e-16 59.4 0.1 1.7e-10 39.2 0.1 2.3 2 1 0 2 2 2 2 Bacterial NAD-glutamate dehydrogenase ADK PF00406.22 ADV24683.1 - 4.4e-38 130.7 0.0 6.4e-38 130.2 0.0 1.2 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 ADV24683.1 - 2.2e-16 60.5 0.0 4.1e-16 59.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain ADK_lid PF05191.14 ADV24683.1 - 2.6e-13 49.7 0.0 4.7e-13 48.9 0.0 1.5 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_18 PF13238.6 ADV24683.1 - 0.00022 21.8 0.0 0.00055 20.5 0.0 1.6 1 1 0 1 1 1 1 AAA domain UBA2_C PF16195.5 ADV24683.1 - 2.1 9.1 8.4 11 6.8 8.4 2.2 1 1 0 1 1 1 0 SUMO-activating enzyme subunit 2 C-terminus Mannosyl_trans3 PF11051.8 ADV24684.1 - 1.7e-26 93.2 0.0 1.6e-16 60.5 0.0 3.0 2 1 1 3 3 3 2 Mannosyltransferase putative bZIP_1 PF00170.21 ADV24685.1 - 8e-10 38.7 16.2 1.3e-08 34.8 10.1 2.3 2 0 0 2 2 2 2 bZIP transcription factor bZIP_2 PF07716.15 ADV24685.1 - 2.7e-08 33.8 16.4 1.4e-07 31.5 7.4 2.4 2 0 0 2 2 2 2 Basic region leucine zipper TPR_MLP1_2 PF07926.12 ADV24685.1 - 0.054 13.6 13.6 0.11 12.5 8.7 2.5 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein DUF4472 PF14739.6 ADV24685.1 - 0.31 11.8 6.6 0.085 13.6 2.7 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4472) TSC22 PF01166.18 ADV24685.1 - 0.43 10.9 3.1 7.7 6.9 0.2 2.4 2 0 0 2 2 2 0 TSC-22/dip/bun family YabA PF06156.13 ADV24685.1 - 0.47 11.1 5.3 16 6.2 0.1 2.5 2 1 0 2 2 2 0 Initiation control protein YabA Sugar_tr PF00083.24 ADV24686.1 - 2.7e-119 399.0 19.9 3.1e-119 398.8 19.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ADV24686.1 - 2.1e-31 109.1 51.0 3.4e-29 101.9 25.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 ADV24686.1 - 0.00043 18.8 7.5 0.025 13.0 0.6 2.1 2 0 0 2 2 2 2 Fungal trichothecene efflux pump (TRI12) MFS_3 PF05977.13 ADV24686.1 - 0.27 9.6 6.6 0.088 11.2 0.2 2.9 3 1 1 4 4 4 0 Transmembrane secretion effector adh_short PF00106.25 ADV24687.1 - 9e-26 90.5 0.0 1.5e-25 89.8 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ADV24687.1 - 1.3e-21 77.3 0.0 5.7e-21 75.2 0.0 1.8 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase 3Beta_HSD PF01073.19 ADV24687.1 - 0.00013 21.1 0.3 0.00022 20.3 0.3 1.5 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family KR PF08659.10 ADV24687.1 - 0.0002 21.3 0.1 0.00032 20.7 0.1 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ADV24687.1 - 0.0013 18.2 0.1 0.0031 17.0 0.1 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ADV24687.1 - 0.0095 15.4 0.0 0.015 14.7 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase AP_endonuc_2 PF01261.24 ADV24688.1 - 1.1e-18 67.5 0.0 4.7e-18 65.4 0.0 2.0 2 1 0 2 2 2 1 Xylose isomerase-like TIM barrel Sugar_tr PF00083.24 ADV24689.1 - 7.3e-83 278.9 21.1 9.1e-83 278.6 21.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ADV24689.1 - 2e-27 96.1 31.7 2.6e-27 95.7 31.7 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 ADV24689.1 - 5.2e-06 25.2 4.7 5.2e-06 25.2 4.7 1.5 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) MFS_1_like PF12832.7 ADV24689.1 - 0.014 14.2 0.3 0.014 14.2 0.3 3.3 2 2 1 3 3 3 0 MFS_1 like family Phage_holin_3_2 PF04550.12 ADV24689.1 - 4.6 7.9 11.1 1 10.0 4.1 2.8 1 1 1 2 2 2 0 Phage holin family 2 GFO_IDH_MocA PF01408.22 ADV24691.1 - 0.21 12.4 0.0 0.32 11.8 0.0 1.3 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold Pyr_redox_3 PF13738.6 ADV24694.1 - 1.7e-17 63.7 0.0 1.7e-15 57.1 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 ADV24694.1 - 1.4e-16 60.0 0.0 2.6e-11 42.7 0.0 2.4 2 1 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 ADV24694.1 - 1.6e-15 57.1 0.0 1.2e-12 47.7 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ADV24694.1 - 3.4e-08 33.9 0.1 0.0021 18.6 0.1 3.8 5 0 0 5 5 4 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ADV24694.1 - 8.7e-07 29.1 0.0 0.00042 20.5 0.0 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 ADV24694.1 - 3.6e-06 26.5 0.0 9.6e-05 21.8 0.0 2.2 2 0 0 2 2 2 1 FAD binding domain K_oxygenase PF13434.6 ADV24694.1 - 5.2e-06 25.8 0.0 0.00043 19.5 0.0 2.8 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.17 ADV24694.1 - 8.3e-06 25.2 0.0 0.078 12.2 0.0 2.3 2 0 0 2 2 2 2 Thi4 family HI0933_like PF03486.14 ADV24694.1 - 1.9e-05 23.6 0.0 0.00033 19.5 0.1 2.3 2 0 0 2 2 2 1 HI0933-like protein GIDA PF01134.22 ADV24694.1 - 3.1e-05 23.3 0.0 0.027 13.5 0.1 2.7 2 1 0 2 2 2 2 Glucose inhibited division protein A FAD_oxidored PF12831.7 ADV24694.1 - 3.2e-05 23.5 0.0 0.0056 16.1 0.0 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase DAO PF01266.24 ADV24694.1 - 3.8e-05 23.5 0.5 0.0059 16.2 0.2 3.1 2 2 1 4 4 4 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 ADV24694.1 - 0.001 18.2 0.0 0.019 14.1 0.0 2.6 3 0 0 3 3 3 1 Lycopene cyclase protein FAD_binding_2 PF00890.24 ADV24694.1 - 0.0014 17.8 0.0 0.0063 15.7 0.1 2.0 2 0 0 2 2 2 1 FAD binding domain NAD_binding_9 PF13454.6 ADV24694.1 - 0.0027 17.7 0.2 1.2 9.1 0.2 3.3 2 1 0 2 2 2 1 FAD-NAD(P)-binding 2-Hacid_dh_C PF02826.19 ADV24694.1 - 0.0061 15.9 0.0 0.4 10.0 0.0 2.3 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Trp_halogenase PF04820.14 ADV24694.1 - 0.036 12.9 1.2 1 8.1 0.3 2.4 2 0 0 2 2 2 0 Tryptophan halogenase NAD_binding_7 PF13241.6 ADV24694.1 - 0.076 13.5 0.0 15 6.1 0.0 3.1 3 1 0 3 3 2 0 Putative NAD(P)-binding TrkA_N PF02254.18 ADV24694.1 - 0.17 12.2 0.0 0.63 10.3 0.0 2.0 2 0 0 2 2 2 0 TrkA-N domain ABC2_membrane PF01061.24 ADV24695.1 - 3.8e-84 281.3 64.5 2.8e-45 154.3 27.3 3.2 4 0 0 4 4 4 2 ABC-2 type transporter PDR_CDR PF06422.12 ADV24695.1 - 3.4e-38 129.5 11.9 1.6e-35 120.8 0.1 3.4 3 0 0 3 3 2 2 CDR ABC transporter ABC_tran PF00005.27 ADV24695.1 - 5.9e-36 124.0 0.0 5.4e-17 62.6 0.0 3.4 3 0 0 3 3 3 2 ABC transporter ABC_trans_N PF14510.6 ADV24695.1 - 2.7e-17 63.1 0.1 9e-17 61.5 0.1 2.0 1 0 0 1 1 1 1 ABC-transporter N-terminal AAA_25 PF13481.6 ADV24695.1 - 1.2e-07 31.5 0.1 1.3e-05 24.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 ADV24695.1 - 1.7e-05 25.3 0.1 0.02 15.3 0.1 2.5 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 ADV24695.1 - 4.4e-05 23.5 0.2 0.0034 17.3 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_33 PF13671.6 ADV24695.1 - 0.00034 20.8 0.0 0.066 13.4 0.1 2.6 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 ADV24695.1 - 0.001 19.6 0.1 0.19 12.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 ADV24695.1 - 0.0013 19.0 0.8 3 8.1 0.1 3.4 3 0 0 3 3 3 1 AAA domain AAA_30 PF13604.6 ADV24695.1 - 0.002 17.9 0.7 1.1 9.0 0.1 2.5 2 0 0 2 2 2 2 AAA domain SMC_N PF02463.19 ADV24695.1 - 0.002 17.6 0.0 0.093 12.2 0.0 3.1 2 2 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA PF00004.29 ADV24695.1 - 0.0023 18.3 0.2 0.69 10.3 0.0 2.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 ADV24695.1 - 0.0036 17.0 2.0 0.031 14.0 0.2 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain NACHT PF05729.12 ADV24695.1 - 0.0042 17.0 0.2 2.5 8.0 0.1 3.1 3 0 0 3 3 3 1 NACHT domain AAA_22 PF13401.6 ADV24695.1 - 0.0048 17.2 0.3 1.7 8.9 0.1 2.8 2 0 0 2 2 2 1 AAA domain AAA_21 PF13304.6 ADV24695.1 - 0.0053 16.6 0.9 3.4 7.4 0.1 2.7 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_17 PF13207.6 ADV24695.1 - 0.0054 17.1 0.2 3.1 8.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 ADV24695.1 - 0.01 15.4 2.2 0.68 9.5 0.3 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain RuvB_N PF05496.12 ADV24695.1 - 0.012 15.4 0.1 0.85 9.4 0.0 2.3 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain Rad17 PF03215.15 ADV24695.1 - 0.061 13.2 0.0 2.5 8.0 0.0 2.4 2 0 0 2 2 2 0 Rad17 P-loop domain T2SSE PF00437.20 ADV24695.1 - 0.084 11.9 0.1 1.2 8.2 0.0 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_5 PF07728.14 ADV24695.1 - 0.14 12.2 0.4 5.2 7.1 0.1 2.4 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Viral_helicase1 PF01443.18 ADV24695.1 - 0.2 11.3 0.1 5.6 6.6 0.0 2.2 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_23 PF13476.6 ADV24695.1 - 0.23 12.0 0.2 0.8 10.2 0.0 2.0 2 0 0 2 2 1 0 AAA domain AAA_24 PF13479.6 ADV24695.1 - 1.2 8.8 3.7 23 4.6 0.2 2.9 4 0 0 4 4 3 0 AAA domain AAA_19 PF13245.6 ADV24695.1 - 1.3 9.3 2.9 4 7.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain DEAD PF00270.29 ADV24696.1 - 8.6e-17 61.4 0.0 1.4e-16 60.7 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase RecQ_Zn_bind PF16124.5 ADV24696.1 - 5.8e-09 36.5 0.0 1.4e-08 35.3 0.0 1.7 1 0 0 1 1 1 1 RecQ zinc-binding Helicase_C PF00271.31 ADV24696.1 - 3.6e-08 33.7 0.0 3.4e-05 24.2 0.0 2.5 2 0 0 2 2 2 2 Helicase conserved C-terminal domain ResIII PF04851.15 ADV24696.1 - 0.00034 20.6 0.0 0.00079 19.5 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit RQC PF09382.10 ADV24696.1 - 0.13 12.1 0.0 3.4 7.5 0.0 2.4 1 1 0 1 1 1 0 RQC domain Methyltr_RsmB-F PF01189.17 ADV24697.1 - 2.4e-42 144.9 0.0 3.7e-40 137.7 0.0 2.2 2 0 0 2 2 2 2 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 ADV24697.1 - 0.00084 19.5 0.0 0.0016 18.6 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase Ras PF00071.22 ADV24698.1 - 4.3e-51 172.7 0.0 5.1e-51 172.5 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ADV24698.1 - 6.7e-30 103.8 0.0 9.7e-30 103.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ADV24698.1 - 3.8e-15 55.8 0.0 1.5e-14 53.9 0.0 1.7 2 0 0 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ADV24698.1 - 5.2e-07 29.7 0.0 8.5e-07 29.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ADV24698.1 - 1.1e-06 28.4 0.0 1e-05 25.2 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ADV24698.1 - 0.0042 17.0 0.0 0.19 11.6 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase SRPRB PF09439.10 ADV24698.1 - 0.0096 15.4 0.0 0.021 14.3 0.0 1.5 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_21 PF13304.6 ADV24698.1 - 0.14 11.9 0.0 12 5.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system Ferric_reduct PF01794.19 ADV24699.1 - 6.2e-19 68.3 12.9 6.2e-19 68.3 12.9 2.5 2 1 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 ADV24699.1 - 3e-13 50.2 0.0 4.8e-13 49.5 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 ADV24699.1 - 6e-12 45.6 0.0 1.3e-11 44.6 0.0 1.4 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_1 PF00175.21 ADV24699.1 - 0.017 15.7 0.0 0.64 10.7 0.0 2.3 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain CAT PF00302.18 ADV24699.1 - 0.057 13.4 1.2 0.091 12.7 1.2 1.2 1 0 0 1 1 1 0 Chloramphenicol acetyltransferase TMEM190 PF15431.6 ADV24699.1 - 0.099 12.8 1.0 0.18 11.9 0.4 1.6 1 1 0 1 1 1 0 Transmembrane protein 190 ANAPC4_WD40 PF12894.7 ADV24700.1 - 3.3e-12 46.5 0.0 0.0014 18.9 0.0 5.9 3 3 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ADV24700.1 - 1.9e-11 44.3 10.6 0.11 13.4 0.1 7.1 6 1 1 7 7 7 4 WD domain, G-beta repeat eIF2A PF08662.11 ADV24700.1 - 0.00039 20.3 0.0 1.4 8.8 0.0 3.2 2 2 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A BUD22 PF09073.10 ADV24700.1 - 0.21 10.9 31.5 0.32 10.3 31.5 1.2 1 0 0 1 1 1 0 BUD22 Nop14 PF04147.12 ADV24700.1 - 0.97 7.6 27.7 1.4 7.1 27.7 1.2 1 0 0 1 1 1 0 Nop14-like family SAPS PF04499.15 ADV24700.1 - 1.3 7.8 11.4 1.8 7.2 11.4 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Sec10 PF07393.11 ADV24701.1 - 2e-236 786.8 0.0 1e-234 781.2 0.0 2.0 1 1 1 2 2 2 2 Exocyst complex component Sec10 AdoHcyase PF05221.17 ADV24702.1 - 1.5e-138 461.0 0.0 1.4e-134 447.9 0.0 2.0 1 1 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 ADV24702.1 - 7.2e-83 276.5 1.0 1.1e-82 275.9 1.0 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 ADV24702.1 - 3.6e-07 29.7 0.0 7.5e-07 28.7 0.0 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 ADV24702.1 - 0.00022 20.8 0.1 0.0004 20.0 0.1 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain TrkA_N PF02254.18 ADV24702.1 - 0.002 18.4 0.0 0.0043 17.3 0.0 1.6 1 0 0 1 1 1 1 TrkA-N domain ELFV_dehydrog PF00208.21 ADV24702.1 - 0.055 13.2 0.1 0.088 12.5 0.1 1.4 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase F420_oxidored PF03807.17 ADV24702.1 - 0.065 13.8 0.3 0.18 12.4 0.1 1.8 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent NAD_binding_7 PF13241.6 ADV24702.1 - 0.086 13.3 0.1 0.21 12.0 0.1 1.7 1 0 0 1 1 1 0 Putative NAD(P)-binding 3HCDH_N PF02737.18 ADV24702.1 - 0.11 12.4 0.2 0.19 11.6 0.2 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox PF00070.27 ADV24702.1 - 0.42 11.2 1.7 7 7.3 0.3 2.7 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase DUF2052 PF09747.9 ADV24705.1 - 1.2e-07 32.1 17.5 1.4e-06 28.6 18.1 1.9 1 1 1 2 2 2 2 Coiled-coil domain containing protein (DUF2052) FAM177 PF14774.6 ADV24705.1 - 0.073 13.5 3.4 0.14 12.6 3.4 1.4 1 0 0 1 1 1 0 FAM177 family ATP-synt_Eps PF04627.13 ADV24706.1 - 1e-17 63.8 2.0 1.3e-17 63.5 2.0 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase epsilon chain Zn_clus PF00172.18 ADV24707.1 - 0.00038 20.5 7.1 0.00064 19.8 7.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Rpr2 PF04032.16 ADV24707.1 - 6.6 7.1 10.2 5.9 7.2 4.0 3.0 2 1 1 3 3 3 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain SKN1 PF03935.15 ADV24708.1 - 8.1e-208 690.9 6.1 9.5e-208 690.6 6.1 1.0 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) Condensation PF00668.20 ADV24708.1 - 0.23 10.1 0.3 0.36 9.4 0.3 1.2 1 0 0 1 1 1 0 Condensation domain MFS_1 PF07690.16 ADV24709.1 - 3.3e-34 118.4 56.0 1e-31 110.2 53.2 2.6 2 1 0 2 2 2 2 Major Facilitator Superfamily RIX1 PF08167.12 ADV24710.1 - 1.7e-11 44.2 0.9 3.4e-11 43.3 0.2 1.9 2 0 0 2 2 2 1 rRNA processing/ribosome biogenesis DUF2770 PF10968.8 ADV24710.1 - 0.49 10.4 2.4 1.2 9.1 2.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2770) Pex24p PF06398.11 ADV24711.1 - 2.5e-18 66.2 17.8 2.3e-17 63.1 17.8 2.3 1 1 0 1 1 1 1 Integral peroxisomal membrane peroxin DUF4663 PF15668.5 ADV24711.1 - 0.67 9.0 2.6 1.1 8.2 2.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4663) FUSC PF04632.12 ADV24713.1 - 2.1 6.8 5.5 2.8 6.4 5.5 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family AA_permease PF00324.21 ADV24714.1 - 6.8e-95 318.4 29.3 8.3e-95 318.1 29.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 ADV24714.1 - 1.9e-20 73.1 35.2 2.4e-20 72.8 35.2 1.2 1 0 0 1 1 1 1 Amino acid permease DUF1772 PF08592.11 ADV24714.1 - 0.044 14.1 0.3 0.044 14.1 0.3 3.6 4 1 0 4 4 4 0 Domain of unknown function (DUF1772) SSF PF00474.17 ADV24715.1 - 4.7e-16 58.7 28.6 4.7e-16 58.7 28.6 1.5 2 0 0 2 2 2 1 Sodium:solute symporter family DUF3169 PF11368.8 ADV24715.1 - 0.056 13.0 0.2 0.056 13.0 0.2 3.6 3 1 0 4 4 4 0 Protein of unknown function (DUF3169) GMC_oxred_N PF00732.19 ADV24721.1 - 2.4e-50 171.6 0.0 3.4e-50 171.1 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 ADV24721.1 - 3.3e-32 112.0 0.0 5.6e-32 111.2 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 ADV24721.1 - 0.0018 17.4 0.9 0.051 12.7 0.2 2.1 2 0 0 2 2 2 1 FAD binding domain DAO PF01266.24 ADV24721.1 - 0.003 17.2 0.2 0.0062 16.2 0.2 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 ADV24721.1 - 0.0033 16.5 0.0 0.0047 16.0 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 ADV24721.1 - 0.0079 16.4 0.1 0.019 15.2 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 ADV24721.1 - 0.012 14.8 0.0 0.021 14.1 0.0 1.3 1 0 0 1 1 1 0 Thi4 family GIDA PF01134.22 ADV24721.1 - 0.021 13.9 1.2 2.9 6.9 0.1 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A Pyr_redox_2 PF07992.14 ADV24721.1 - 0.026 13.8 0.1 0.052 12.8 0.1 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Reovirus_Mu2 PF07781.11 ADV24721.1 - 0.23 9.8 0.0 0.32 9.3 0.0 1.1 1 0 0 1 1 1 0 Reovirus minor core protein Mu-2 Catalase PF00199.19 ADV24722.1 - 2.2e-175 583.3 0.0 2.7e-175 583.1 0.0 1.1 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 ADV24722.1 - 4.4e-09 36.4 0.0 8.6e-09 35.5 0.0 1.5 1 0 0 1 1 1 1 Catalase-related immune-responsive Fungal_trans PF04082.18 ADV24723.1 - 7.1e-13 48.2 0.3 1.3e-12 47.3 0.3 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ADV24723.1 - 7.7e-09 35.5 12.0 1.4e-08 34.7 12.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain GspL_C PF12693.7 ADV24723.1 - 0.031 14.1 0.1 0.059 13.2 0.1 1.4 1 0 0 1 1 1 0 GspL periplasmic domain YjeF_N PF03853.15 ADV24724.1 - 1.3e-34 119.5 0.0 1.7e-34 119.2 0.0 1.1 1 0 0 1 1 1 1 YjeF-related protein N-terminus FERM_M PF00373.18 ADV24724.1 - 0.095 13.1 0.0 0.21 12.0 0.0 1.5 1 1 0 1 1 1 0 FERM central domain BRX PF08381.11 ADV24724.1 - 0.23 10.9 0.1 0.43 10.0 0.1 1.4 1 0 0 1 1 1 0 Transcription factor regulating root and shoot growth via Pin3 NDC10_II PF16787.5 ADV24725.1 - 3.3e-73 246.5 0.0 4.6e-73 246.1 0.0 1.2 1 0 0 1 1 1 1 Centromere DNA-binding protein complex CBF3 subunit, domain 2 Peptidase_S10 PF00450.22 ADV24726.1 - 5.4e-82 276.4 0.3 7.2e-82 276.0 0.3 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Ribonuc_L-PSP PF01042.21 ADV24728.1 - 2.5e-23 82.4 0.0 2.7e-23 82.3 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP zf-H2C2_2 PF13465.6 ADV24730.1 - 3.8e-06 27.1 2.8 3.8e-06 27.1 2.8 3.0 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2 PF00096.26 ADV24730.1 - 1.3e-05 25.4 2.9 1.3e-05 25.4 2.9 2.8 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ADV24730.1 - 0.00027 21.5 14.3 0.0029 18.3 1.9 2.8 3 0 0 3 3 3 2 C2H2-type zinc finger zf_UBZ PF18439.1 ADV24730.1 - 0.34 10.6 3.9 6.5 6.4 0.8 2.5 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger DUF2688 PF10892.8 ADV24730.1 - 0.36 10.3 2.2 7.1 6.2 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2688) zf-met PF12874.7 ADV24730.1 - 1 9.9 5.4 2.9 8.4 0.4 2.7 2 0 0 2 2 2 0 Zinc-finger of C2H2 type Zn-ribbon_8 PF09723.10 ADV24730.1 - 1.2 9.3 3.5 3 8.1 2.8 2.0 1 1 0 1 1 1 0 Zinc ribbon domain zf-C2HC_2 PF13913.6 ADV24730.1 - 2.4 8.2 7.9 0.93 9.5 1.8 2.4 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-C2H2_6 PF13912.6 ADV24730.1 - 6.9 6.8 11.3 4.9 7.3 1.5 2.9 3 0 0 3 3 3 0 C2H2-type zinc finger Usp PF00582.26 ADV24731.1 - 0.11 12.9 0.0 0.23 12.0 0.0 1.5 1 0 0 1 1 1 0 Universal stress protein family M20_dimer PF07687.14 ADV24732.1 - 3.7e-08 33.3 0.5 1e-07 31.8 0.1 1.9 2 0 0 2 2 2 1 Peptidase dimerisation domain Peptidase_M20 PF01546.28 ADV24732.1 - 7.2e-06 25.8 0.0 1.4e-05 24.9 0.0 1.5 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 MFS_1 PF07690.16 ADV24733.1 - 4.7e-30 104.7 24.9 4.7e-30 104.7 24.9 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily Got1 PF04178.12 ADV24733.1 - 0.36 11.3 6.0 0.31 11.5 1.9 3.0 3 0 0 3 3 3 0 Got1/Sft2-like family ADK PF00406.22 ADV24734.1 - 7.6e-59 198.1 0.0 9.7e-59 197.8 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 ADV24734.1 - 2.3e-22 79.9 0.0 3.7e-22 79.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain ADK_lid PF05191.14 ADV24734.1 - 3.4e-17 62.1 0.0 6.2e-17 61.3 0.0 1.5 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_33 PF13671.6 ADV24734.1 - 6.5e-06 26.4 0.0 1e-05 25.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ADV24734.1 - 0.0021 18.6 0.0 0.0042 17.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ADV24734.1 - 0.01 16.2 0.0 0.021 15.2 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain TSC22 PF01166.18 ADV24734.1 - 0.15 12.4 0.0 0.37 11.1 0.0 1.6 1 0 0 1 1 1 0 TSC-22/dip/bun family Fungal_trans PF04082.18 ADV24736.1 - 1.6e-10 40.5 1.2 9.8e-09 34.6 1.1 2.2 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ADV24736.1 - 1.8e-06 28.0 13.1 3.8e-06 26.9 13.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Exo_endo_phos PF03372.23 ADV24737.1 - 3.6e-05 23.4 0.0 6.7e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family CDC45 PF02724.14 ADV24737.1 - 1.2 7.4 13.7 2.3 6.4 13.7 1.4 1 0 0 1 1 1 0 CDC45-like protein DUF4797 PF16051.5 ADV24737.1 - 5.3 7.1 6.6 1.6 8.8 0.3 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4797) ATP-synt_C PF00137.21 ADV24738.1 - 1e-33 115.4 35.8 5.8e-22 77.8 15.0 2.1 2 0 0 2 2 2 2 ATP synthase subunit C DUF4577 PF15145.6 ADV24738.1 - 0.26 11.4 0.4 0.44 10.6 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4577) Peptidase_S10 PF00450.22 ADV24739.1 - 6.9e-38 131.1 0.0 7.8e-38 131.0 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Ribosomal_S7 PF00177.21 ADV24741.1 - 3.9e-36 123.9 1.7 5.2e-36 123.5 1.7 1.1 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e PHY PF00360.20 ADV24742.1 - 3.6e-29 101.4 0.0 7.7e-29 100.3 0.0 1.5 1 0 0 1 1 1 1 Phytochrome region HATPase_c PF02518.26 ADV24742.1 - 7.1e-20 71.6 0.2 1.9e-19 70.2 0.2 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ADV24742.1 - 1.3e-14 54.4 0.6 3.4e-14 52.9 0.6 1.8 1 1 0 1 1 1 1 Response regulator receiver domain GAF PF01590.26 ADV24742.1 - 1.3e-13 51.8 0.0 6.3e-13 49.5 0.0 2.3 1 0 0 1 1 1 1 GAF domain HisKA PF00512.25 ADV24742.1 - 2.1e-08 34.1 1.7 7.4e-08 32.3 1.7 2.0 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_2 PF08446.11 ADV24742.1 - 0.0019 18.9 0.0 0.0081 16.8 0.0 2.1 1 0 0 1 1 1 1 PAS fold OKR_DC_1_N PF03709.15 ADV24742.1 - 0.053 13.8 0.1 0.17 12.2 0.1 1.8 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, N-terminal domain Gln-synt_N PF03951.19 ADV24743.1 - 0.02 14.6 0.5 0.031 14.0 0.5 1.3 1 0 0 1 1 1 0 Glutamine synthetase, beta-Grasp domain Herpes_capsid PF06112.11 ADV24743.1 - 0.21 11.7 14.3 0.26 11.3 14.3 1.2 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein TAL_FSA PF00923.19 ADV24744.1 - 1.2e-97 326.7 0.0 1.4e-97 326.5 0.0 1.0 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase Corona_NS1 PF06145.11 ADV24745.1 - 0.11 12.1 2.7 0.18 11.4 2.7 1.3 1 0 0 1 1 1 0 Coronavirus nonstructural protein NS1 Pyr_redox_2 PF07992.14 ADV24747.1 - 2.1e-08 33.8 0.0 0.0027 17.0 0.1 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase cobW PF02492.19 ADV24747.1 - 0.13 11.9 0.0 0.22 11.1 0.0 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain KHA PF11834.8 ADV24747.1 - 0.15 12.1 0.0 0.5 10.5 0.0 1.8 2 0 0 2 2 2 0 KHA, dimerisation domain of potassium ion channel His_Phos_1 PF00300.22 ADV24748.1 - 0.077 12.7 0.1 12 5.5 0.0 2.6 3 0 0 3 3 3 0 Histidine phosphatase superfamily (branch 1) CPBP PF02517.16 ADV24749.1 - 2.1e-14 53.6 2.2 2.1e-14 53.6 2.2 2.3 3 0 0 3 3 3 1 CPBP intramembrane metalloprotease SNF2_N PF00176.23 ADV24751.1 - 1.4e-66 224.6 0.0 1.1e-65 221.7 0.0 2.1 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ADV24751.1 - 1.3e-19 70.6 0.0 2.7e-19 69.6 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 ADV24751.1 - 4.1e-09 36.7 0.0 3.3e-08 33.7 0.0 2.5 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 ADV24751.1 - 4.7e-09 35.8 0.0 8.5e-08 31.7 0.0 2.9 3 1 0 3 3 3 1 Class II histone deacetylase complex subunits 2 and 3 Fungal_trans PF04082.18 ADV24752.1 - 2.7e-08 33.2 1.1 3.9e-08 32.6 0.1 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 ADV24752.1 - 5.7e-08 32.8 11.3 0.0012 19.1 3.3 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ADV24752.1 - 1.8e-06 28.1 1.8 1.8e-06 28.1 1.8 2.2 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_8 PF15909.5 ADV24752.1 - 0.0017 18.6 0.6 0.0046 17.2 0.6 1.7 1 0 0 1 1 1 1 C2H2-type zinc ribbon zf-C2H2_4 PF13894.6 ADV24752.1 - 0.01 16.6 17.6 0.12 13.3 3.0 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_6 PF13912.6 ADV24752.1 - 0.086 12.9 0.4 0.24 11.5 0.4 1.8 1 0 0 1 1 1 0 C2H2-type zinc finger Fungal_trans PF04082.18 ADV24753.1 - 1.9e-08 33.7 0.4 1.4e-07 30.8 0.4 2.1 1 1 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 ADV24753.1 - 0.0018 18.7 8.6 0.1 13.1 0.2 3.0 1 1 1 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ADV24753.1 - 0.25 12.3 8.0 2.9 9.0 0.2 3.1 1 1 1 2 2 2 0 C2H2-type zinc finger OPT PF03169.15 ADV24755.1 - 2.9e-174 581.1 46.9 3.3e-174 581.0 46.9 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein LapA_dom PF06305.11 ADV24755.1 - 9.3 6.2 5.8 9.3 6.1 2.4 2.9 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Coq4 PF05019.13 ADV24756.1 - 7.1e-79 264.2 0.0 8.2e-79 264.0 0.0 1.0 1 0 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 MFS_1 PF07690.16 ADV24757.1 - 4.7e-27 94.8 83.2 2.4e-23 82.7 57.3 2.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Proteasome PF00227.26 ADV24758.1 - 8.7e-28 97.1 0.0 1.1e-27 96.8 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Aldo_ket_red PF00248.21 ADV24759.1 - 9.9e-73 244.9 0.0 1.2e-72 244.6 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family DUF913 PF06025.12 ADV24760.1 - 0.25 10.3 2.6 0.41 9.6 2.6 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Presenilin PF01080.17 ADV24760.1 - 0.67 8.7 4.2 1.2 7.9 4.2 1.3 1 0 0 1 1 1 0 Presenilin FAM176 PF14851.6 ADV24760.1 - 2.2 7.9 7.7 5.6 6.6 7.7 1.6 1 0 0 1 1 1 0 FAM176 family Spt20 PF12090.8 ADV24760.1 - 4.1 6.9 10.3 2.9 7.4 2.9 2.4 3 0 0 3 3 3 0 Spt20 family V_ATPase_I PF01496.19 ADV24760.1 - 7.5 4.3 5.9 11 3.8 5.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family GSP_synth PF03738.14 ADV24761.1 - 0.15 11.2 0.0 0.18 10.9 0.0 1.1 1 0 0 1 1 1 0 Glutathionylspermidine synthase preATP-grasp IF4E PF01652.18 ADV24764.1 - 2.4e-31 108.7 0.0 3.1e-31 108.3 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E SRP_TPR_like PF17004.5 ADV24765.1 - 0.021 14.8 3.1 0.18 11.9 0.2 2.2 2 0 0 2 2 2 0 Putative TPR-like repeat MbeD_MobD PF04899.12 ADV24765.1 - 0.029 14.5 1.3 0.029 14.5 1.3 2.4 2 0 0 2 2 2 0 MbeD/MobD like DUF4472 PF14739.6 ADV24765.1 - 0.34 11.7 12.9 0.6 10.9 9.8 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4472) MFS_1 PF07690.16 ADV24767.1 - 9.8e-32 110.2 35.2 3.9e-30 105.0 35.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Phage_holin_2_4 PF16082.5 ADV24767.1 - 0.06 13.1 0.1 0.06 13.1 0.1 2.4 2 0 0 2 2 2 0 Bacteriophage holin family, superfamily II-like UPF0242 PF06785.11 ADV24767.1 - 0.15 12.1 0.0 0.38 10.8 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus adh_short_C2 PF13561.6 ADV24768.1 - 1.6e-51 175.1 0.0 3.7e-50 170.7 0.0 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ADV24768.1 - 6.1e-41 140.0 0.3 1.9e-40 138.4 0.3 1.6 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ADV24768.1 - 2.6e-09 37.3 0.1 5.2e-08 33.0 0.0 2.1 2 0 0 2 2 2 1 KR domain PEP_mutase PF13714.6 ADV24768.1 - 0.0076 15.7 0.0 0.011 15.2 0.0 1.2 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase F420_oxidored PF03807.17 ADV24768.1 - 0.022 15.3 0.1 0.056 14.0 0.1 1.8 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Epimerase PF01370.21 ADV24768.1 - 0.082 12.4 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Fungal_trans PF04082.18 ADV24769.1 - 8.4e-22 77.5 0.1 4.7e-21 75.0 0.0 2.1 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ADV24769.1 - 2.7e-08 33.8 13.6 4.5e-08 33.1 13.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ADH_N PF08240.12 ADV24770.1 - 2.3e-25 88.6 3.6 4.1e-25 87.8 3.6 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ADV24770.1 - 8.4e-14 51.7 0.0 1.4e-13 51.0 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 ADV24770.1 - 6.6e-05 22.5 0.1 0.00028 20.4 0.1 1.9 2 0 0 2 2 2 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 ADV24770.1 - 0.05 14.7 0.0 0.3 12.1 0.0 2.1 1 1 0 1 1 1 0 Zinc-binding dehydrogenase Ribosomal_S8 PF00410.19 ADV24771.1 - 3.7e-24 85.1 0.2 5.5e-24 84.5 0.2 1.3 1 1 0 1 1 1 1 Ribosomal protein S8 ADH_N PF08240.12 ADV24772.1 - 1.1e-23 83.2 1.2 1.8e-23 82.5 1.2 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ADV24772.1 - 1.1e-20 73.9 0.0 1.8e-20 73.2 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 ADV24772.1 - 2.8e-06 26.8 0.1 4.1e-06 26.2 0.1 1.1 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 ADV24772.1 - 2.2e-05 23.9 0.0 3.4e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Glu_dehyd_C PF16912.5 ADV24772.1 - 0.0059 16.1 0.0 0.0083 15.6 0.0 1.1 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus NAD_binding_2 PF03446.15 ADV24772.1 - 0.017 15.3 0.0 0.026 14.7 0.0 1.2 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase ELFV_dehydrog PF00208.21 ADV24772.1 - 0.049 13.3 0.1 0.075 12.7 0.1 1.2 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase GFO_IDH_MocA PF01408.22 ADV24772.1 - 0.052 14.4 0.0 0.099 13.5 0.0 1.4 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_7 PF13241.6 ADV24772.1 - 0.1 13.1 0.0 0.18 12.3 0.0 1.3 1 0 0 1 1 1 0 Putative NAD(P)-binding 3HCDH_N PF02737.18 ADV24772.1 - 0.16 11.8 0.1 0.23 11.3 0.1 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GLTP PF08718.11 ADV24774.1 - 1.1e-50 171.8 0.0 1.4e-50 171.5 0.0 1.2 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) Cnd1 PF12717.7 ADV24775.1 - 1.3e-53 181.4 2.3 1.4e-50 171.5 0.4 3.4 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 Cnd1_N PF12922.7 ADV24775.1 - 5e-50 169.6 1.4 4.5e-49 166.5 0.0 3.5 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1, N-term Adaptin_N PF01602.20 ADV24775.1 - 3.7e-07 29.1 9.0 0.00071 18.3 0.2 4.4 4 2 1 5 5 5 2 Adaptin N terminal region HEAT_2 PF13646.6 ADV24775.1 - 9.1e-07 29.2 0.1 0.0029 18.0 0.0 4.1 3 1 0 3 3 3 1 HEAT repeats HEAT PF02985.22 ADV24775.1 - 2.5e-06 27.3 5.3 0.076 13.3 0.0 7.0 8 0 0 8 8 8 1 HEAT repeat Cnd3 PF12719.7 ADV24775.1 - 2.7e-06 26.8 2.7 6.3e-05 22.3 0.5 2.7 2 0 0 2 2 2 1 Nuclear condensing complex subunits, C-term domain HEAT_EZ PF13513.6 ADV24775.1 - 0.00078 19.9 2.3 0.096 13.2 0.0 4.3 5 1 1 6 6 6 1 HEAT-like repeat RTP1_C1 PF10363.9 ADV24775.1 - 0.0071 16.5 1.6 7.1 6.9 0.0 4.3 3 2 1 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 YtzH PF14165.6 ADV24775.1 - 0.04 14.3 0.7 0.69 10.4 0.2 3.3 2 1 0 2 2 2 0 YtzH-like protein PqqD PF05402.12 ADV24775.1 - 0.29 11.5 3.0 6.1 7.2 0.0 4.3 5 0 0 5 5 5 0 Coenzyme PQQ synthesis protein D (PqqD) Motile_Sperm PF00635.26 ADV24776.1 - 5.1e-25 87.4 0.0 5e-24 84.3 0.0 2.1 1 1 1 2 2 2 1 MSP (Major sperm protein) domain ASH PF15780.5 ADV24776.1 - 7.5e-05 22.9 0.2 0.00025 21.2 0.1 1.8 2 0 0 2 2 2 1 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin dCMP_cyt_deam_1 PF00383.23 ADV24777.1 - 2e-07 30.8 0.0 3e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 ADV24777.1 - 3.4e-05 23.6 0.0 5.2e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 MafB19-like deaminase Bd3614-deam PF14439.6 ADV24777.1 - 0.025 14.7 0.2 1.1 9.3 0.2 2.3 1 1 0 1 1 1 0 Bd3614-like deaminase DUF1771 PF08590.10 ADV24778.1 - 1.9e-13 50.5 7.8 3.6e-13 49.7 7.8 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1771) zf_CCCH_4 PF18345.1 ADV24778.1 - 1.1e-07 31.7 13.2 7.9e-06 25.8 3.7 2.8 2 1 0 2 2 2 2 Zinc finger domain zf-CCCH PF00642.24 ADV24778.1 - 2.1e-07 30.7 12.6 0.00016 21.5 2.6 2.5 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 ADV24778.1 - 4.9e-07 29.4 14.8 0.00026 20.7 2.3 2.7 2 1 0 2 2 2 2 CCCH-type zinc finger Torus PF16131.5 ADV24778.1 - 1.1e-06 29.3 4.4 3.4e-05 24.5 0.2 2.6 1 1 1 2 2 2 2 Torus domain zf-CCCH_2 PF14608.6 ADV24778.1 - 0.0037 17.7 12.9 0.063 13.8 1.9 2.5 2 0 0 2 2 2 2 RNA-binding, Nab2-type zinc finger zf-C3H1 PF10650.9 ADV24778.1 - 0.013 15.2 4.6 0.94 9.3 0.6 2.5 2 0 0 2 2 2 0 Putative zinc-finger domain Smr PF01713.21 ADV24778.1 - 0.013 15.9 0.1 0.033 14.5 0.1 1.7 1 0 0 1 1 1 0 Smr domain HBS1_N PF08938.10 ADV24778.1 - 0.085 13.2 0.0 0.23 11.8 0.0 1.7 1 0 0 1 1 1 0 HBS1 N-terminus zf-CCCH_3 PF15663.5 ADV24778.1 - 0.09 13.0 4.0 6 7.1 0.3 2.2 1 1 1 2 2 2 0 Zinc-finger containing family Ribosomal_L36 PF00444.18 ADV24779.1 - 3.2e-22 78.5 9.4 5.1e-22 77.8 9.4 1.3 1 0 0 1 1 1 1 Ribosomal protein L36 Arc_trans_TRASH PF08394.10 ADV24779.1 - 6.7 7.1 6.8 0.6 10.5 1.2 1.9 2 0 0 2 2 2 0 Archaeal TRASH domain Ribosomal_L14 PF00238.19 ADV24780.1 - 6.8e-35 119.8 0.0 8.3e-35 119.5 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e TFIID_30kDa PF03540.13 ADV24781.1 - 2.5e-22 78.5 0.0 4.2e-22 77.8 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit Bromo_TP PF07524.13 ADV24781.1 - 0.011 15.7 0.0 0.052 13.6 0.0 1.9 2 0 0 2 2 2 0 Bromodomain associated RhoGAP PF00620.27 ADV24782.1 - 1.6e-19 70.2 0.0 2.3e-19 69.7 0.0 1.2 1 0 0 1 1 1 1 RhoGAP domain Gti1_Pac2 PF09729.9 ADV24783.1 - 3.5e-59 200.0 0.0 5.5e-59 199.3 0.0 1.3 1 0 0 1 1 1 1 Gti1/Pac2 family HGTP_anticodon2 PF12745.7 ADV24784.1 - 0.0075 15.8 0.0 0.0087 15.6 0.0 1.0 1 0 0 1 1 1 1 Anticodon binding domain of tRNAs SKG6 PF08693.10 ADV24785.1 - 5.4e-07 28.9 5.3 1.5e-06 27.5 5.3 1.7 1 0 0 1 1 1 1 Transmembrane alpha-helix domain DUF4448 PF14610.6 ADV24785.1 - 0.00031 20.6 0.2 0.00052 19.9 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) DUF1180 PF06679.12 ADV24785.1 - 0.015 15.7 0.5 0.015 15.7 0.5 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1180) TMEM154 PF15102.6 ADV24785.1 - 0.027 14.4 0.1 0.027 14.4 0.1 1.7 2 0 0 2 2 2 0 TMEM154 protein family DUF3377 PF11857.8 ADV24785.1 - 0.089 12.7 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) RIFIN PF02009.16 ADV24785.1 - 0.19 11.6 0.0 0.29 11.0 0.0 1.2 1 0 0 1 1 1 0 Rifin VSP PF03302.13 ADV24785.1 - 0.25 10.1 1.4 0.46 9.3 1.4 1.3 1 0 0 1 1 1 0 Giardia variant-specific surface protein GPI-anchored PF10342.9 ADV24785.1 - 0.5 11.2 4.6 0.14 12.9 0.7 2.2 2 0 0 2 2 2 0 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family DUF4690 PF15756.5 ADV24785.1 - 3.1 8.5 7.0 0.76 10.4 1.6 2.6 2 0 0 2 2 2 0 Small Novel Rich in Cartilage Glyco_hydro_47 PF01532.20 ADV24786.1 - 1e-82 278.5 0.0 1.6e-82 277.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 PA PF02225.22 ADV24786.1 - 0.00097 19.1 0.0 0.0065 16.5 0.0 2.2 1 1 1 2 2 2 1 PA domain LANC_like PF05147.13 ADV24786.1 - 0.055 12.0 0.1 0.1 11.1 0.1 1.4 1 0 0 1 1 1 0 Lanthionine synthetase C-like protein COX4 PF02936.14 ADV24787.1 - 5.9e-40 136.5 0.3 7.1e-40 136.2 0.3 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV BLI1 PF17324.2 ADV24787.1 - 0.063 13.9 0.0 0.12 13.0 0.0 1.4 1 0 0 1 1 1 0 BLOC-1 interactor 1 UEV PF05743.13 ADV24789.1 - 0.049 13.5 0.0 3.2 7.6 0.0 2.0 1 1 1 2 2 2 0 UEV domain PDH PF02153.17 ADV24792.1 - 4.1e-15 55.5 0.0 5.7e-15 55.0 0.0 1.1 1 0 0 1 1 1 1 Prephenate dehydrogenase F420_oxidored PF03807.17 ADV24792.1 - 3.6e-07 30.7 0.0 1.3e-06 28.9 0.0 1.9 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 ADV24792.1 - 6.8e-05 23.1 0.0 0.00012 22.3 0.0 1.5 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.19 ADV24792.1 - 0.00014 21.3 0.0 0.00024 20.5 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 ADV24792.1 - 0.0057 16.7 0.0 0.012 15.7 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.18 ADV24792.1 - 0.0074 16.5 0.0 0.015 15.5 0.0 1.5 1 0 0 1 1 1 1 TrkA-N domain ApbA PF02558.16 ADV24792.1 - 0.0097 15.6 0.0 0.017 14.7 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Rossmann-like PF10727.9 ADV24792.1 - 0.07 13.0 0.1 0.14 12.0 0.1 1.5 1 0 0 1 1 1 0 Rossmann-like domain adh_short_C2 PF13561.6 ADV24793.1 - 5.6e-40 137.3 0.0 9.8e-40 136.6 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ADV24793.1 - 2e-33 115.5 0.1 2.9e-33 115.0 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ADV24793.1 - 7.2e-14 52.1 0.0 1e-13 51.6 0.0 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ADV24793.1 - 0.00031 20.3 0.0 0.00066 19.2 0.0 1.5 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NAD_binding_2 PF03446.15 ADV24793.1 - 0.043 14.0 0.0 1.3 9.2 0.0 2.3 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase Methyltransf_25 PF13649.6 ADV24793.1 - 0.048 14.4 0.0 0.11 13.2 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain GDP_Man_Dehyd PF16363.5 ADV24793.1 - 0.12 11.8 0.0 0.18 11.2 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 ADV24793.1 - 0.18 10.8 0.0 0.27 10.2 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family DUF5403 PF17395.2 ADV24794.1 - 0.26 11.6 1.5 0.58 10.5 1.5 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5403) OTU PF02338.19 ADV24795.1 - 2.1e-18 67.0 0.0 3.3e-18 66.4 0.0 1.3 1 0 0 1 1 1 1 OTU-like cysteine protease eIF3_subunit PF08597.10 ADV24795.1 - 0.049 13.5 0.0 0.079 12.9 0.0 1.4 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Peptidase_C65 PF10275.9 ADV24795.1 - 0.09 12.2 0.0 2 7.8 0.0 2.1 1 1 0 2 2 2 0 Peptidase C65 Otubain CN_hydrolase PF00795.22 ADV24796.1 - 8.5e-12 45.0 0.0 8.3e-11 41.7 0.0 2.4 2 1 0 2 2 2 1 Carbon-nitrogen hydrolase PBP PF01161.20 ADV24797.1 - 2.2e-12 47.4 0.0 3.8e-12 46.7 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein CCD PF07860.11 ADV24798.1 - 0.0048 16.9 4.8 0.0048 16.9 4.8 3.1 3 1 0 4 4 4 1 WisP family C-Terminal Region Methyltransf_34 PF11312.8 ADV24798.1 - 1.4 8.0 4.1 15 4.7 0.6 2.2 2 0 0 2 2 2 0 Putative SAM-dependent methyltransferase Arylsulfotrans PF05935.11 ADV24799.1 - 4.8e-26 91.6 0.0 4.1e-14 52.3 0.0 2.1 1 1 1 2 2 2 2 Arylsulfotransferase (ASST) Arylsulfotran_2 PF14269.6 ADV24799.1 - 2.8e-14 53.2 0.0 6.6e-14 52.0 0.0 1.7 1 1 0 1 1 1 1 Arylsulfotransferase (ASST) PQQ_2 PF13360.6 ADV24799.1 - 4.7e-05 23.1 0.0 0.16 11.5 0.0 2.9 2 1 1 3 3 3 2 PQQ-like domain TPR_2 PF07719.17 ADV24800.1 - 4.8e-05 23.2 12.9 0.098 12.8 0.0 6.0 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 ADV24800.1 - 0.0005 20.5 3.8 2.3 8.8 0.3 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 ADV24800.1 - 0.059 13.4 2.3 18 5.6 0.1 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.6 ADV24800.1 - 0.13 12.9 4.8 21 5.9 0.0 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 ADV24800.1 - 0.13 12.1 7.3 3.6 7.6 0.0 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.6 ADV24800.1 - 0.65 11.0 3.2 44 5.3 0.0 5.4 6 1 1 7 7 7 0 Tetratricopeptide repeat BNR_4 PF15892.5 ADV24801.1 - 0.032 13.6 0.0 0.048 13.0 0.0 1.2 1 0 0 1 1 1 0 BNR repeat-containing family member MFS_1 PF07690.16 ADV24802.1 - 9.5e-27 93.8 36.6 1.5e-26 93.2 35.1 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily Na_H_antiport_2 PF13726.6 ADV24802.1 - 9.2 6.5 8.8 0.38 10.9 1.9 2.2 2 0 0 2 2 2 0 Na+-H+ antiporter family MFS_1 PF07690.16 ADV24803.1 - 1.6e-06 27.3 3.5 2.9e-06 26.5 3.5 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily MWFE PF15879.5 ADV24803.1 - 0.039 14.1 0.3 0.17 12.0 0.0 2.2 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase MWFE subunit Aminotran_1_2 PF00155.21 ADV24805.1 - 3.6e-26 92.2 0.0 5.2e-16 58.8 0.0 3.0 2 1 0 2 2 2 2 Aminotransferase class I and II bPH_5 PF10882.8 ADV24805.1 - 0.14 12.3 0.0 0.31 11.2 0.0 1.5 1 0 0 1 1 1 0 Bacterial PH domain Aa_trans PF01490.18 ADV24806.1 - 1.1e-31 110.0 37.0 1.2e-31 109.8 37.0 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein ResIII PF04851.15 ADV24806.1 - 0.21 11.6 0.4 0.35 10.9 0.4 1.2 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit GFO_IDH_MocA PF01408.22 ADV24807.1 - 2.2e-10 41.4 0.1 4.9e-10 40.3 0.1 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Sugar_tr PF00083.24 ADV24809.1 - 9.2e-110 367.6 27.2 1.1e-109 367.3 27.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ADV24809.1 - 7.8e-24 84.3 28.4 7.8e-24 84.3 28.4 1.9 1 1 0 2 2 2 1 Major Facilitator Superfamily Dynein_light PF01221.18 ADV24809.1 - 0.35 11.2 1.1 17 5.8 0.0 2.7 2 0 0 2 2 2 0 Dynein light chain type 1 Asp PF00026.23 ADV24811.1 - 5.8e-24 85.1 0.0 2e-23 83.3 0.0 1.8 1 1 0 1 1 1 1 Eukaryotic aspartyl protease DnaJ PF00226.31 ADV24812.1 - 5.9e-19 68.0 1.1 1.1e-18 67.1 1.1 1.5 1 0 0 1 1 1 1 DnaJ domain TPR_1 PF00515.28 ADV24813.1 - 2.8e-19 68.1 0.1 1.7e-05 24.5 0.0 5.2 4 1 1 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.17 ADV24813.1 - 4.4e-19 67.0 2.0 0.00045 20.1 0.1 5.5 4 1 1 5 5 5 4 Tetratricopeptide repeat TPR_11 PF13414.6 ADV24813.1 - 1.8e-11 43.5 0.0 0.00077 19.1 0.0 4.5 3 1 1 4 4 4 2 TPR repeat TPR_16 PF13432.6 ADV24813.1 - 2e-09 37.9 4.8 6e-08 33.2 0.2 3.9 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 ADV24813.1 - 3.4e-08 33.1 0.5 0.002 18.2 0.0 5.1 5 1 1 6 6 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 ADV24813.1 - 5e-08 33.1 11.5 0.0095 16.7 0.1 6.0 3 1 3 6 6 6 2 Tetratricopeptide repeat TPR_12 PF13424.6 ADV24813.1 - 1.3e-06 28.6 6.9 0.011 16.0 0.3 4.6 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 ADV24813.1 - 1.7e-06 27.6 0.1 0.025 14.6 0.0 4.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 ADV24813.1 - 2.7e-06 27.4 0.1 1.4 9.4 0.0 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 ADV24813.1 - 3.6e-05 24.2 0.5 0.36 11.4 0.0 3.2 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 ADV24813.1 - 8.2e-05 23.0 0.2 0.85 10.4 0.0 4.8 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_3 PF07720.12 ADV24813.1 - 0.0024 17.9 0.0 0.26 11.3 0.0 3.4 4 0 0 4 4 4 1 Tetratricopeptide repeat DUF4810 PF16068.5 ADV24813.1 - 0.079 13.5 2.2 1 9.9 0.0 3.5 4 0 0 4 4 3 0 Domain of unknown function (DUF4810) TPR_9 PF13371.6 ADV24813.1 - 0.094 12.9 0.5 3.5 7.9 0.0 3.4 3 1 0 4 4 4 0 Tetratricopeptide repeat TPR_15 PF13429.6 ADV24813.1 - 0.23 10.6 3.3 1.1 8.5 0.1 2.9 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 ADV24813.1 - 0.33 10.9 9.0 8.8 6.3 0.1 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat MFS_1 PF07690.16 ADV24814.1 - 1.5e-36 126.1 27.9 1.1e-35 123.2 27.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily PgaD PF13994.6 ADV24814.1 - 0.049 13.7 0.1 0.55 10.3 0.1 2.5 2 0 0 2 2 2 0 PgaD-like protein ArsA_ATPase PF02374.15 ADV24816.1 - 3.1e-112 374.7 0.1 3.6e-112 374.5 0.1 1.0 1 0 0 1 1 1 1 Anion-transporting ATPase CbiA PF01656.23 ADV24816.1 - 4.5e-12 46.1 0.0 8.7e-12 45.2 0.0 1.7 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 ADV24816.1 - 3.5e-11 43.3 0.2 2e-10 40.9 0.0 2.2 2 1 0 2 2 2 1 AAA domain ParA PF10609.9 ADV24816.1 - 3.5e-05 23.4 0.2 0.00028 20.4 0.0 2.2 2 0 0 2 2 2 1 NUBPL iron-transfer P-loop NTPase Fer4_NifH PF00142.18 ADV24816.1 - 6.4e-05 22.5 0.1 0.00015 21.3 0.1 1.6 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family CBP_BcsQ PF06564.12 ADV24816.1 - 7.5e-05 22.3 0.0 0.00016 21.3 0.0 1.4 1 0 0 1 1 1 1 Cellulose biosynthesis protein BcsQ SRP54 PF00448.22 ADV24816.1 - 0.0011 18.6 0.0 0.0084 15.8 0.0 2.1 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_25 PF13481.6 ADV24816.1 - 0.0061 16.2 0.1 0.025 14.2 0.1 1.9 1 1 0 1 1 1 1 AAA domain VirC1 PF07015.11 ADV24816.1 - 0.048 12.9 0.5 0.088 12.1 0.0 1.6 2 0 0 2 2 2 0 VirC1 protein RNA_helicase PF00910.22 ADV24816.1 - 0.14 12.6 0.0 3.6 8.0 0.0 2.4 2 0 0 2 2 2 0 RNA helicase Zeta_toxin PF06414.12 ADV24816.1 - 0.14 11.4 0.0 0.25 10.6 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin NCBP3 PF10309.9 ADV24817.1 - 5.2e-05 23.0 0.0 9.3e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 Nuclear cap-binding protein subunit 3 RNA_bind PF08675.11 ADV24817.1 - 0.025 14.6 0.0 0.044 13.8 0.0 1.3 1 0 0 1 1 1 0 RNA binding domain UPF0086 PF01868.16 ADV24818.1 - 1.8e-19 69.4 0.0 3e-19 68.7 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function UPF0086 CRS1_YhbY PF01985.21 ADV24818.1 - 0.11 12.7 1.1 0.2 11.9 1.1 1.4 1 0 0 1 1 1 0 CRS1 / YhbY (CRM) domain Ribonuc_red_sm PF00268.21 ADV24819.1 - 9.4e-118 392.7 0.7 1.2e-117 392.4 0.7 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain Epimerase PF01370.21 ADV24820.1 - 7.1e-08 32.2 0.0 0.00074 19.0 0.0 2.1 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ADV24820.1 - 0.092 11.7 0.0 0.15 11.0 0.0 1.4 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 ADV24820.1 - 0.1 12.5 0.0 1.1 9.2 0.0 2.2 2 0 0 2 2 2 0 NAD(P)H-binding RmlD_sub_bind PF04321.17 ADV24820.1 - 0.15 11.1 0.0 0.25 10.4 0.0 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain CN_hydrolase PF00795.22 ADV24821.1 - 2.3e-36 125.5 0.0 3.4e-36 124.9 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase NAD_synthase PF02540.17 ADV24821.1 - 9.7e-24 83.8 0.0 4.5e-23 81.6 0.0 1.9 1 1 0 1 1 1 1 NAD synthase Fmp27_WPPW PF10359.9 ADV24821.1 - 0.09 11.6 0.2 11 4.7 0.1 2.2 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain Pkinase PF00069.25 ADV24822.1 - 2.7e-39 135.1 0.0 6.7e-21 74.8 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ADV24822.1 - 5e-14 52.2 0.0 9e-14 51.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase FTA2 PF13095.6 ADV24822.1 - 0.0087 15.7 0.0 2.8 7.5 0.0 2.4 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 FHA PF00498.26 ADV24823.1 - 0.0037 17.6 0.0 0.013 15.9 0.0 1.9 2 0 0 2 2 2 1 FHA domain Yop-YscD_cpl PF16697.5 ADV24823.1 - 0.075 13.4 0.3 0.53 10.6 0.0 2.2 2 0 0 2 2 2 0 Inner membrane component of T3SS, cytoplasmic domain NUDIX PF00293.28 ADV24824.1 - 1.3e-08 34.9 0.0 3.7e-08 33.5 0.0 1.7 2 0 0 2 2 2 1 NUDIX domain DUF4743 PF15916.5 ADV24824.1 - 8.6e-05 22.5 0.0 0.0056 16.6 0.0 2.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4743) NUDIX PF00293.28 ADV24825.1 - 4.8e-07 29.9 0.0 3e-06 27.3 0.0 1.9 2 0 0 2 2 2 1 NUDIX domain DUF4743 PF15916.5 ADV24825.1 - 0.00012 22.0 0.0 0.0022 17.9 0.0 2.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4743) WD40 PF00400.32 ADV24826.1 - 1.5e-21 76.3 3.7 2.7e-06 28.0 0.0 4.9 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV24826.1 - 1.2e-05 25.5 0.0 0.41 11.0 0.0 3.5 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 ADV24826.1 - 0.018 13.6 0.0 0.1 11.1 0.0 2.1 3 0 0 3 3 3 0 Cytochrome D1 heme domain Nup160 PF11715.8 ADV24826.1 - 0.081 11.6 0.1 13 4.3 0.0 3.0 1 1 1 3 3 3 0 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ADV24826.1 - 0.14 10.8 0.9 31 3.1 0.0 3.4 3 2 0 4 4 4 0 Nup133 N terminal like PHTB1_N PF14727.6 ADV24826.1 - 0.29 10.5 0.6 3.1 7.1 0.1 2.4 2 1 1 3 3 3 0 PTHB1 N-terminus DUF1917 PF08939.10 ADV24826.1 - 2.6 7.9 7.8 0.42 10.5 0.1 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF1917) Bromodomain PF00439.25 ADV24827.1 - 5.5e-34 116.1 0.4 1.4e-17 63.5 0.5 2.9 2 1 0 2 2 2 2 Bromodomain BET PF17035.5 ADV24827.1 - 3e-17 62.5 0.1 7.4e-17 61.3 0.1 1.7 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation DUF3138 PF11336.8 ADV24827.1 - 0.011 14.4 0.1 0.02 13.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) AATF-Che1 PF13339.6 ADV24827.1 - 1.1 9.9 7.8 4.4 8.0 6.5 2.7 2 1 0 2 2 2 0 Apoptosis antagonizing transcription factor DUF2868 PF11067.8 ADV24827.1 - 3.4 7.1 9.0 0.52 9.8 1.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2868) Aldo_ket_red PF00248.21 ADV24828.1 - 4.5e-48 164.0 0.0 9.2e-47 159.6 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family STAT1_TAZ2bind PF12162.8 ADV24828.1 - 0.043 13.4 0.0 0.082 12.5 0.0 1.4 1 0 0 1 1 1 0 STAT1 TAZ2 binding domain tRNA-synt_2 PF00152.20 ADV24829.1 - 1.9e-87 293.3 0.0 2.3e-86 289.7 0.0 2.0 1 1 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 ADV24829.1 - 6.2e-06 26.1 0.0 1.3e-05 25.1 0.0 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain DUF4983 PF16356.5 ADV24829.1 - 0.18 12.6 0.0 2.5 8.9 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4983) Senescence PF06911.12 ADV24830.1 - 1.1e-19 71.5 10.6 1.6e-19 70.9 10.6 1.2 1 0 0 1 1 1 1 Senescence-associated protein GST_N_2 PF13409.6 ADV24831.1 - 2.9e-21 75.6 0.1 8.2e-21 74.1 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 ADV24831.1 - 6.1e-15 55.0 0.0 1.3e-14 53.9 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ADV24831.1 - 2.2e-08 34.2 0.0 3.8e-08 33.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 ADV24831.1 - 4.3e-05 23.6 0.0 8.3e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Lentivirus_VIF PF05851.11 ADV24831.1 - 0.012 14.6 0.1 0.021 13.7 0.1 1.3 1 0 0 1 1 1 0 Lentivirus virion infectivity factor (VIF) GST_N_3 PF13417.6 ADV24831.1 - 0.017 15.5 0.0 1.5 9.2 0.0 2.4 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain Integrase_H2C2 PF17921.1 ADV24833.1 - 3.1e-10 40.0 0.2 6.8e-10 38.9 0.2 1.6 1 1 0 1 1 1 1 Integrase zinc binding domain Tash_PEST PF07708.11 ADV24833.1 - 6.1 7.1 6.1 0.66 10.2 0.6 2.2 2 0 0 2 2 2 0 Tash protein PEST motif PAP_assoc PF03828.19 ADV24834.1 - 8.3e-18 64.4 2.6 8.4e-18 64.3 0.3 2.4 2 0 0 2 2 2 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 ADV24834.1 - 2.6e-05 24.4 0.0 0.00011 22.5 0.0 2.1 1 0 0 1 1 1 1 Nucleotidyltransferase domain DNA_pol_B_palm PF14792.6 ADV24834.1 - 0.0065 16.7 0.0 0.029 14.6 0.0 2.1 2 0 0 2 2 2 1 DNA polymerase beta palm DOT1 PF08123.13 ADV24835.1 - 3.8e-52 176.8 0.0 5.4e-52 176.3 0.0 1.2 1 0 0 1 1 1 1 Histone methylation protein DOT1 Forkhead PF00250.18 ADV24836.1 - 0.12 12.7 0.0 0.23 11.7 0.0 1.5 1 0 0 1 1 1 0 Forkhead domain Peptidase_S10 PF00450.22 ADV24837.1 - 1.1e-105 354.5 0.0 1.4e-105 354.1 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase GFO_IDH_MocA PF01408.22 ADV24838.1 - 2.8e-22 79.8 0.6 4.5e-22 79.1 0.6 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_3 PF03447.16 ADV24838.1 - 0.082 13.6 1.1 0.16 12.6 0.3 1.9 2 0 0 2 2 2 0 Homoserine dehydrogenase, NAD binding domain RabGAP-TBC PF00566.18 ADV24839.1 - 1.5e-31 109.7 0.5 4.2e-15 56.0 0.1 2.2 2 0 0 2 2 2 2 Rab-GTPase-TBC domain S36_mt PF10937.8 ADV24839.1 - 0.044 15.4 0.5 0.14 13.7 0.5 1.9 1 0 0 1 1 1 0 Ribosomal protein S36, mitochondrial MAPEG PF01124.18 ADV24840.1 - 1.8e-19 70.0 0.3 2.1e-19 69.7 0.3 1.0 1 0 0 1 1 1 1 MAPEG family ETF PF01012.21 ADV24841.1 - 1.4e-43 148.9 0.1 2e-43 148.4 0.1 1.1 1 0 0 1 1 1 1 Electron transfer flavoprotein domain EFG_C PF00679.24 ADV24841.1 - 0.016 15.2 0.0 2.7 8.1 0.0 2.5 2 0 0 2 2 2 0 Elongation factor G C-terminus DnaJ PF00226.31 ADV24842.1 - 0.055 13.6 0.5 0.11 12.7 0.5 1.5 1 0 0 1 1 1 0 DnaJ domain WD40 PF00400.32 ADV24843.1 - 4e-34 116.1 8.4 2e-07 31.6 0.0 7.0 7 0 0 7 7 7 6 WD domain, G-beta repeat Nup160 PF11715.8 ADV24843.1 - 1.1e-07 30.9 0.1 0.0096 14.6 0.0 3.9 4 1 1 5 5 5 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ADV24843.1 - 0.0004 20.6 0.0 3.2 8.1 0.0 4.1 3 2 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain EzrA PF06160.12 ADV24843.1 - 0.089 11.0 1.3 0.13 10.4 1.3 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA Ank_2 PF12796.7 ADV24845.1 - 2.3e-40 137.0 1.5 1.3e-16 61.0 0.1 3.1 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ADV24845.1 - 9.2e-39 131.3 5.6 4.1e-11 43.2 0.0 4.9 2 1 3 5 5 5 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 ADV24845.1 - 2.6e-36 123.2 4.4 1.1e-11 44.8 0.1 5.3 2 1 3 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 ADV24845.1 - 1.8e-32 107.7 1.2 1.9e-06 27.7 0.0 5.7 6 0 0 6 6 6 5 Ankyrin repeat Ank PF00023.30 ADV24845.1 - 3.4e-31 106.3 3.8 2e-06 28.0 0.1 5.3 5 0 0 5 5 5 5 Ankyrin repeat Glyoxalase_6 PF18029.1 ADV24845.1 - 0.022 15.5 0.4 0.89 10.4 0.2 2.3 2 0 0 2 2 2 0 Glyoxalase-like domain SNF2_N PF00176.23 ADV24846.1 - 6.6e-73 245.4 1.1 1.2e-72 244.6 1.1 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ADV24846.1 - 3.5e-20 72.4 0.0 1.5e-19 70.3 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HSA PF07529.13 ADV24846.1 - 5.1e-20 71.6 5.2 5.1e-20 71.6 5.2 2.6 2 0 0 2 2 2 1 HSA Bromodomain PF00439.25 ADV24846.1 - 6.7e-18 64.5 0.1 1.8e-17 63.2 0.1 1.8 1 0 0 1 1 1 1 Bromodomain SnAC PF14619.6 ADV24846.1 - 7.9e-14 52.0 1.4 7.9e-14 52.0 1.4 3.5 4 0 0 4 4 4 1 Snf2-ATP coupling, chromatin remodelling complex ResIII PF04851.15 ADV24846.1 - 2.1e-10 40.9 0.0 5.9e-10 39.4 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit QLQ PF08880.11 ADV24846.1 - 1.2e-09 37.8 2.4 2.3e-09 36.8 2.4 1.5 1 0 0 1 1 1 1 QLQ NUDIX PF00293.28 ADV24847.1 - 3.5e-11 43.3 0.0 8.1e-11 42.1 0.0 1.6 1 0 0 1 1 1 1 NUDIX domain DUF2458 PF10454.9 ADV24847.1 - 0.13 11.9 0.6 0.23 11.1 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2458) DUF899 PF05988.12 ADV24847.1 - 0.2 11.2 2.2 0.35 10.4 2.2 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF899) Aminotran_1_2 PF00155.21 ADV24848.1 - 7.1e-47 160.3 0.0 8.5e-47 160.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II KTI12 PF08433.10 ADV24849.1 - 3e-78 263.0 0.0 3.9e-78 262.7 0.0 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_33 PF13671.6 ADV24849.1 - 1e-07 32.2 0.0 1.7e-07 31.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ADV24849.1 - 0.00012 22.6 0.0 0.0002 21.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 ADV24849.1 - 0.033 14.5 0.0 0.058 13.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain APS_kinase PF01583.20 ADV24849.1 - 0.11 12.4 0.0 0.59 10.0 0.0 1.9 2 0 0 2 2 2 0 Adenylylsulphate kinase WD40 PF00400.32 ADV24850.1 - 1.8e-07 31.7 5.6 0.0025 18.6 0.0 5.1 5 1 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV24850.1 - 1.2e-05 25.5 0.0 1.6 9.1 0.0 4.0 4 1 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ctr PF04145.15 ADV24851.1 - 3.3e-28 99.2 5.4 1.1e-27 97.5 5.4 1.7 1 1 0 1 1 1 1 Ctr copper transporter family DUF962 PF06127.11 ADV24851.1 - 0.51 10.5 4.9 4.9 7.3 4.9 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF962) SSP160 PF06933.11 ADV24852.1 - 0.019 13.2 9.3 0.025 12.8 9.3 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DHHC PF01529.20 ADV24852.1 - 0.46 10.6 2.1 12 5.9 0.4 2.9 3 0 0 3 3 3 0 DHHC palmitoyltransferase SR-25 PF10500.9 ADV24852.1 - 1.2 8.7 20.6 1.7 8.2 20.6 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF508 PF04370.12 ADV24852.1 - 3.3 7.4 10.1 40 3.9 10.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF508) Rav1p_C PF12234.8 ADV24853.1 - 7.1e-182 606.2 0.0 9.7e-182 605.7 0.0 1.1 1 0 0 1 1 1 1 RAVE protein 1 C terminal GMP_synt_C PF00958.22 ADV24854.1 - 1.6e-43 146.7 0.1 2.9e-43 145.8 0.1 1.5 1 0 0 1 1 1 1 GMP synthase C terminal domain GATase PF00117.28 ADV24854.1 - 2.8e-34 118.6 0.0 4.7e-34 117.8 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I NAD_synthase PF02540.17 ADV24854.1 - 9.2e-11 41.3 0.1 3.5e-06 26.3 0.0 2.3 2 0 0 2 2 2 2 NAD synthase Peptidase_C26 PF07722.13 ADV24854.1 - 3.4e-09 36.8 0.0 6.7e-09 35.8 0.0 1.4 1 0 0 1 1 1 1 Peptidase C26 tRNA_Me_trans PF03054.16 ADV24854.1 - 0.0035 16.2 0.1 0.006 15.4 0.1 1.4 1 0 0 1 1 1 1 tRNA methyl transferase ThiI PF02568.14 ADV24854.1 - 0.0048 16.5 0.1 0.008 15.8 0.1 1.3 1 0 0 1 1 1 1 Thiamine biosynthesis protein (ThiI) QueC PF06508.13 ADV24854.1 - 0.0072 15.8 0.0 0.03 13.8 0.0 1.8 2 0 0 2 2 2 1 Queuosine biosynthesis protein QueC Arginosuc_synth PF00764.19 ADV24854.1 - 0.031 13.6 0.1 0.048 12.9 0.1 1.2 1 0 0 1 1 1 0 Arginosuccinate synthase ATP_bind_3 PF01171.20 ADV24854.1 - 0.046 13.5 0.2 0.11 12.2 0.0 1.7 2 0 0 2 2 2 0 PP-loop family HOASN PF14515.6 ADV24854.1 - 0.18 12.2 0.2 0.39 11.1 0.2 1.5 1 0 0 1 1 1 0 Haem-oxygenase-associated N-terminal helices GrpE PF01025.19 ADV24855.1 - 1.6e-47 161.3 3.0 2.1e-47 160.9 3.0 1.1 1 0 0 1 1 1 1 GrpE DUF812 PF05667.11 ADV24855.1 - 0.0035 16.3 4.2 0.0041 16.1 4.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF812) TolA_bind_tri PF16331.5 ADV24855.1 - 0.055 13.5 0.2 0.12 12.5 0.2 1.5 1 0 0 1 1 1 0 TolA binding protein trimerisation UPF0242 PF06785.11 ADV24855.1 - 0.12 12.4 2.7 0.19 11.8 2.7 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Phlebovirus_NSM PF07246.11 ADV24855.1 - 0.18 11.1 1.2 0.23 10.8 1.2 1.1 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M Ax_dynein_light PF10211.9 ADV24855.1 - 0.29 11.1 5.8 0.55 10.2 5.8 1.5 1 0 0 1 1 1 0 Axonemal dynein light chain Pex19 PF04614.12 ADV24855.1 - 0.31 10.8 5.9 0.4 10.4 5.9 1.1 1 0 0 1 1 1 0 Pex19 protein family DUF4337 PF14235.6 ADV24855.1 - 0.4 10.8 7.4 0.64 10.1 7.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) XhlA PF10779.9 ADV24855.1 - 0.4 10.9 2.7 0.72 10.1 2.3 1.7 1 1 0 1 1 1 0 Haemolysin XhlA Ribosomal_L3 PF00297.22 ADV24856.1 - 7.2e-182 604.4 9.5 8.1e-182 604.2 9.5 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 PPP1R35_C PF15503.6 ADV24857.1 - 3.9 7.3 11.7 0.69 9.7 1.2 2.8 3 0 0 3 3 3 0 Protein phosphatase 1 regulatory subunit 35 C-terminus Meth_synt_2 PF01717.18 ADV24858.1 - 6e-151 502.3 0.0 1.3e-147 491.3 0.0 2.6 3 0 0 3 3 3 2 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.12 ADV24858.1 - 1.9e-109 366.0 0.0 4.3e-102 341.8 0.0 3.0 3 0 0 3 3 3 2 Cobalamin-independent synthase, N-terminal domain SHOCT PF09851.9 ADV24858.1 - 0.017 14.8 2.2 0.058 13.1 1.0 2.7 2 0 0 2 2 2 0 Short C-terminal domain Rad51 PF08423.11 ADV24859.1 - 5.7e-27 94.6 0.0 9.4e-14 51.3 0.0 3.3 3 1 0 3 3 3 2 Rad51 DnaB_C PF03796.15 ADV24859.1 - 6.5e-05 22.4 0.0 0.00044 19.7 0.0 2.0 1 1 0 1 1 1 1 DnaB-like helicase C terminal domain ATPase PF06745.13 ADV24859.1 - 0.00011 21.6 0.0 0.00023 20.6 0.0 1.5 1 0 0 1 1 1 1 KaiC AAA_25 PF13481.6 ADV24859.1 - 0.00027 20.6 0.1 0.17 11.5 0.0 2.8 2 1 0 2 2 2 2 AAA domain RecA PF00154.21 ADV24859.1 - 0.0023 17.4 0.4 0.0047 16.4 0.1 1.6 2 0 0 2 2 2 1 recA bacterial DNA recombination protein GST_N_2 PF13409.6 ADV24860.1 - 1.3e-21 76.7 0.1 3.7e-21 75.2 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 ADV24860.1 - 6.7e-12 45.3 2.7 5.1e-07 29.6 0.2 2.7 3 0 0 3 3 3 2 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ADV24860.1 - 1.9e-07 31.2 0.8 0.00027 21.1 0.1 2.5 2 1 0 2 2 2 2 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 ADV24860.1 - 0.00072 19.7 0.1 0.0048 17.1 0.1 2.3 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 ADV24860.1 - 0.0096 16.3 0.0 1.1 9.7 0.0 2.4 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain MIP-T3_C PF17749.1 ADV24860.1 - 0.15 12.0 0.0 0.22 11.5 0.0 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 C-terminal region GST_C_6 PF17171.4 ADV24860.1 - 0.3 10.9 2.6 0.85 9.5 0.4 2.3 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain Prefoldin PF02996.17 ADV24862.1 - 8.4e-28 96.7 3.7 1.1e-27 96.3 3.7 1.2 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin_2 PF01920.20 ADV24862.1 - 5e-05 23.2 10.6 0.00052 19.9 2.3 2.2 2 0 0 2 2 2 2 Prefoldin subunit Seryl_tRNA_N PF02403.22 ADV24862.1 - 0.0056 16.9 2.0 2.6 8.3 0.1 2.2 2 0 0 2 2 2 2 Seryl-tRNA synthetase N-terminal domain DASH_Dad2 PF08654.10 ADV24862.1 - 0.039 14.4 9.3 0.27 11.7 1.3 2.2 2 0 0 2 2 2 0 DASH complex subunit Dad2 COG2 PF06148.11 ADV24862.1 - 0.043 13.9 2.9 4.4 7.4 0.1 2.2 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Cep57_MT_bd PF06657.13 ADV24862.1 - 0.045 14.2 2.5 1.4 9.4 0.4 2.4 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 T3SSipB PF16535.5 ADV24862.1 - 0.047 14.2 0.5 0.047 14.2 0.5 2.1 2 0 0 2 2 2 0 Type III cell invasion protein SipB Prefoldin_3 PF13758.6 ADV24862.1 - 0.073 13.1 2.1 0.46 10.6 2.1 2.0 1 1 0 1 1 1 0 Prefoldin subunit TACC_C PF05010.14 ADV24862.1 - 0.084 12.7 8.5 0.52 10.1 2.1 2.1 2 0 0 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal DUF1664 PF07889.12 ADV24862.1 - 0.087 12.9 7.1 0.54 10.3 1.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) AIP3 PF03915.13 ADV24862.1 - 0.11 11.6 6.0 0.14 11.2 6.0 1.1 1 0 0 1 1 1 0 Actin interacting protein 3 DUF4795 PF16043.5 ADV24862.1 - 0.12 12.0 6.3 0.36 10.4 6.3 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) HIP1_clath_bdg PF16515.5 ADV24862.1 - 0.14 12.8 11.7 0.47 11.1 1.9 2.2 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF4201 PF13870.6 ADV24862.1 - 0.14 11.9 8.3 0.11 12.2 1.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) Fib_alpha PF08702.10 ADV24862.1 - 0.3 11.3 7.4 1.5 9.0 1.0 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Spc7 PF08317.11 ADV24862.1 - 0.33 9.8 8.4 0.44 9.4 1.5 2.0 2 0 0 2 2 2 0 Spc7 kinetochore protein Mod_r PF07200.13 ADV24862.1 - 0.38 10.8 11.4 0.25 11.4 3.1 2.1 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein CLZ PF16526.5 ADV24862.1 - 1.1 9.7 11.3 4.4 7.7 1.3 2.5 3 0 0 3 3 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels NPV_P10 PF05531.12 ADV24862.1 - 2.5 8.6 10.5 1.9 9.0 0.6 2.4 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Bap31_Bap29_C PF18035.1 ADV24862.1 - 3 7.9 8.8 2.6 8.1 1.5 2.5 2 0 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain Laminin_II PF06009.12 ADV24862.1 - 3.2 7.8 9.7 7.1 6.6 2.3 2.1 2 0 0 2 2 2 0 Laminin Domain II DUF4407 PF14362.6 ADV24862.1 - 7.1 5.9 10.4 4.1 6.7 2.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) UPF0449 PF15136.6 ADV24862.1 - 7.9 7.0 9.5 3 8.4 1.7 2.2 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 TPR_1 PF00515.28 ADV24863.1 - 5.7e-54 177.9 24.4 1.6e-06 27.7 0.1 10.9 11 1 0 11 11 11 9 Tetratricopeptide repeat TPR_2 PF07719.17 ADV24863.1 - 5.2e-48 157.3 20.5 1.7e-05 24.5 0.1 10.6 11 0 0 11 11 10 9 Tetratricopeptide repeat TPR_8 PF13181.6 ADV24863.1 - 4.8e-36 120.0 13.8 0.00016 21.7 1.8 10.6 10 1 0 10 10 10 8 Tetratricopeptide repeat TPR_14 PF13428.6 ADV24863.1 - 1.8e-30 103.0 10.8 7.2e-05 23.3 0.2 8.8 3 3 5 8 8 8 8 Tetratricopeptide repeat TPR_17 PF13431.6 ADV24863.1 - 4.7e-29 98.7 14.0 0.00036 20.7 0.3 10.2 10 0 0 10 10 10 6 Tetratricopeptide repeat TPR_16 PF13432.6 ADV24863.1 - 1.6e-25 89.5 14.5 6.5e-06 26.7 0.1 6.9 6 1 1 7 7 7 6 Tetratricopeptide repeat TPR_19 PF14559.6 ADV24863.1 - 5.1e-24 84.6 7.3 5.7e-05 23.5 0.3 7.3 4 2 2 6 6 6 4 Tetratricopeptide repeat TPR_6 PF13174.6 ADV24863.1 - 9.4e-20 69.9 12.5 0.15 12.8 0.0 9.8 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_12 PF13424.6 ADV24863.1 - 1.5e-19 70.0 20.6 0.00057 20.1 0.1 7.6 3 2 4 7 7 7 5 Tetratricopeptide repeat TPR_11 PF13414.6 ADV24863.1 - 3e-19 68.4 26.1 6.2e-06 25.8 1.0 9.7 6 3 4 10 10 10 4 TPR repeat TPR_7 PF13176.6 ADV24863.1 - 3e-18 64.4 17.4 0.065 13.3 0.5 9.5 10 0 0 10 10 9 6 Tetratricopeptide repeat TPR_9 PF13371.6 ADV24863.1 - 1.7e-16 60.1 10.0 0.019 15.1 0.3 6.1 2 1 6 8 8 8 7 Tetratricopeptide repeat TPR_15 PF13429.6 ADV24863.1 - 2.8e-08 33.3 10.0 0.095 11.9 3.9 5.5 1 1 3 4 4 4 3 Tetratricopeptide repeat ANAPC3 PF12895.7 ADV24863.1 - 7.8e-07 29.2 6.0 2.5e-05 24.4 2.3 3.0 3 0 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 BTAD PF03704.17 ADV24863.1 - 0.0007 20.1 9.6 0.27 11.6 0.7 3.4 3 0 0 3 3 3 2 Bacterial transcriptional activator domain TOM20_plant PF06552.12 ADV24863.1 - 0.0029 17.4 0.5 1.5 8.5 0.0 3.5 3 2 0 3 3 3 1 Plant specific mitochondrial import receptor subunit TOM20 TPR_20 PF14561.6 ADV24863.1 - 0.015 15.7 5.5 0.044 14.1 0.1 4.2 5 1 1 6 6 6 0 Tetratricopeptide repeat ChAPs PF09295.10 ADV24863.1 - 0.1 11.5 1.0 11 4.9 0.1 2.9 3 0 0 3 3 3 0 ChAPs (Chs5p-Arf1p-binding proteins) SNAP PF14938.6 ADV24863.1 - 6.4 6.1 12.4 42 3.4 1.9 4.7 3 1 2 5 5 5 0 Soluble NSF attachment protein, SNAP Aa_trans PF01490.18 ADV24864.1 - 2e-82 277.1 13.9 2.4e-82 276.8 13.9 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein MMM1 PF10296.9 ADV24865.1 - 4.4e-09 35.8 0.2 5.5e-05 22.4 0.1 2.4 2 0 0 2 2 2 2 Maintenance of mitochondrial morphology protein 1 Pkinase PF00069.25 ADV24866.1 - 6.1e-73 245.4 0.0 8.8e-73 244.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV24866.1 - 2.5e-44 151.5 0.0 4e-44 150.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase POLO_box PF00659.18 ADV24866.1 - 8.8e-34 115.5 0.1 1.2e-15 57.5 0.0 2.6 2 0 0 2 2 2 2 POLO box duplicated region Kinase-like PF14531.6 ADV24866.1 - 1.3e-10 41.1 0.0 3.5e-08 33.1 0.0 2.3 2 0 0 2 2 2 2 Kinase-like Haspin_kinase PF12330.8 ADV24866.1 - 0.0018 17.3 0.7 0.0052 15.8 0.1 1.9 2 0 0 2 2 2 1 Haspin like kinase domain Pkinase_fungal PF17667.1 ADV24866.1 - 0.0075 15.1 0.4 0.041 12.7 0.0 2.2 2 0 0 2 2 2 1 Fungal protein kinase DUF4520 PF15016.6 ADV24866.1 - 0.02 15.0 0.1 0.054 13.6 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4520) Kdo PF06293.14 ADV24866.1 - 0.021 14.2 0.1 0.049 13.0 0.1 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family VPS9 PF02204.18 ADV24866.1 - 0.036 14.3 0.1 0.086 13.1 0.1 1.6 1 0 0 1 1 1 0 Vacuolar sorting protein 9 (VPS9) domain APH PF01636.23 ADV24866.1 - 0.26 11.2 0.9 1.1 9.1 0.2 2.3 2 1 1 3 3 3 0 Phosphotransferase enzyme family HEM4 PF02602.15 ADV24867.1 - 1.2e-26 93.5 0.0 2e-26 92.8 0.0 1.3 1 1 0 1 1 1 1 Uroporphyrinogen-III synthase HemD BRCT_2 PF16589.5 ADV24868.1 - 0.0018 18.6 0.0 0.0036 17.7 0.0 1.5 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 ADV24868.1 - 0.023 15.1 0.0 0.049 14.0 0.0 1.5 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain SWIRM-assoc_2 PF16496.5 ADV24868.1 - 0.023 13.6 0.3 0.023 13.6 0.3 2.0 3 0 0 3 3 3 0 SWIRM-associated domain at the N-terminal DUF2040 PF09745.9 ADV24869.1 - 1.4e-35 122.0 24.8 1.4e-35 122.0 24.8 4.3 3 1 0 4 4 4 1 Coiled-coil domain-containing protein 55 (DUF2040) Sec6 PF06046.13 ADV24870.1 - 1.8e-167 558.2 5.4 1.8e-167 558.2 5.4 1.4 2 0 0 2 2 2 1 Exocyst complex component Sec6 SKA2 PF16740.5 ADV24870.1 - 0.41 10.4 4.6 2.2 8.1 1.6 3.1 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 Peptidase_M75 PF09375.10 ADV24870.1 - 1.2 8.5 6.0 0.26 10.7 0.1 2.6 3 0 0 3 3 3 0 Imelysin AP_endonuc_2 PF01261.24 ADV24871.1 - 2.8e-09 36.7 0.0 6.5e-09 35.5 0.0 1.6 2 0 0 2 2 2 1 Xylose isomerase-like TIM barrel MutS_V PF00488.21 ADV24872.1 - 4.1e-66 222.6 0.0 7.7e-66 221.7 0.0 1.5 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 ADV24872.1 - 2.1e-37 129.2 0.1 4.5e-37 128.1 0.1 1.6 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.20 ADV24872.1 - 8.9e-35 119.3 0.1 8e-34 116.3 0.0 2.3 2 0 0 2 2 2 1 MutS domain I MutS_II PF05188.17 ADV24872.1 - 8.7e-11 42.2 0.0 2.1e-10 41.0 0.0 1.6 1 0 0 1 1 1 1 MutS domain II MutS_IV PF05190.18 ADV24872.1 - 3e-08 33.9 0.0 8.8e-08 32.4 0.0 1.9 1 0 0 1 1 1 1 MutS family domain IV MerR_1 PF13411.6 ADV24872.1 - 0.052 13.6 0.0 0.74 9.9 0.0 2.5 2 0 0 2 2 2 0 MerR HTH family regulatory protein AAA_29 PF13555.6 ADV24872.1 - 0.055 13.2 0.0 0.14 12.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.6 ADV24872.1 - 0.061 13.8 0.1 2.9 8.3 0.0 2.6 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 ADV24872.1 - 0.12 12.9 0.0 0.43 11.1 0.0 2.0 1 0 0 1 1 1 0 ABC transporter DUF4196 PF13846.6 ADV24872.1 - 0.14 12.3 8.1 0.36 11.0 8.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4196) AIP3 PF03915.13 ADV24873.1 - 1.1e-115 387.0 4.4 1.7e-115 386.4 4.4 1.3 1 0 0 1 1 1 1 Actin interacting protein 3 DUF4407 PF14362.6 ADV24873.1 - 1.7e-05 24.3 6.9 0.00037 20.0 0.0 3.3 2 1 1 3 3 3 1 Domain of unknown function (DUF4407) WEMBL PF05701.11 ADV24873.1 - 0.079 11.6 15.6 0.14 10.8 0.5 2.7 2 1 1 3 3 3 0 Weak chloroplast movement under blue light DP PF08781.10 ADV24873.1 - 0.23 11.4 2.4 0.73 9.7 0.3 2.7 3 0 0 3 3 3 0 Transcription factor DP MerR-DNA-bind PF09278.11 ADV24873.1 - 0.49 11.0 5.5 3.1 8.4 0.4 3.4 2 0 0 2 2 2 0 MerR, DNA binding Ribosomal_L29 PF00831.23 ADV24873.1 - 1.8 8.6 9.9 0.037 14.0 1.5 2.6 3 0 0 3 3 3 0 Ribosomal L29 protein TMCO5 PF14992.6 ADV24873.1 - 2.7 7.5 8.7 1.4 8.5 5.4 2.0 2 0 0 2 2 2 0 TMCO5 family KxDL PF10241.9 ADV24873.1 - 4.8 7.5 8.0 6.9 7.0 1.9 3.6 3 0 0 3 3 3 0 Uncharacterized conserved protein Rx_N PF18052.1 ADV24873.1 - 4.9 7.5 6.6 19 5.6 0.1 3.5 2 1 0 2 2 2 0 Rx N-terminal domain ubiquitin PF00240.23 ADV24874.1 - 4.8e-170 551.7 25.8 1.9e-33 114.0 0.5 5.0 5 0 0 5 5 5 5 Ubiquitin family Rad60-SLD PF11976.8 ADV24874.1 - 1.8e-78 258.3 27.9 2.9e-15 55.9 0.7 5.0 5 0 0 5 5 5 5 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 ADV24874.1 - 3.7e-28 97.8 13.3 0.00064 20.1 0.1 6.9 5 5 0 5 5 5 5 Ubiquitin-like domain TBK1_ULD PF18396.1 ADV24874.1 - 1.3e-19 69.9 5.6 0.04 13.8 0.0 5.2 5 0 0 5 5 5 5 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 ADV24874.1 - 1.3e-17 63.9 4.5 0.16 12.1 0.0 6.0 5 4 0 5 5 5 5 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 ADV24874.1 - 1.5e-17 63.7 12.0 0.044 14.1 0.1 5.1 5 0 0 5 5 5 5 Ubiquitin-like domain DUF2407 PF10302.9 ADV24874.1 - 4.9e-16 59.2 2.2 0.54 10.8 0.0 5.2 1 1 0 5 5 5 5 DUF2407 ubiquitin-like domain Sde2_N_Ubi PF13019.6 ADV24874.1 - 1.7e-12 47.5 0.9 1 9.1 0.0 5.1 1 1 4 5 5 5 5 Silencing defective 2 N-terminal ubiquitin domain Methyltrans_RNA PF04452.14 ADV24874.1 - 3.7e-09 36.2 1.8 1.4 8.2 0.0 4.2 4 0 0 4 4 4 4 RNA methyltransferase Ubiquitin_4 PF18036.1 ADV24874.1 - 1.1e-07 31.7 32.6 21 5.2 0.2 9.9 10 0 0 10 10 10 0 Ubiquitin-like domain DUF2870 PF11069.8 ADV24874.1 - 2e-07 31.3 0.0 40 4.7 0.0 5.8 5 0 0 5 5 5 0 Protein of unknown function (DUF2870) Big_7 PF17957.1 ADV24874.1 - 2.8e-07 31.2 0.6 41 5.0 0.0 5.1 5 0 0 5 5 5 0 Bacterial Ig domain DUF3861 PF12977.7 ADV24874.1 - 5.6e-07 29.6 5.5 18 5.6 0.0 5.2 5 0 0 5 5 5 0 Domain of Unknown Function with PDB structure (DUF3861) TmoB PF06234.12 ADV24874.1 - 1.2e-06 28.5 0.1 40 4.4 0.0 5.7 5 0 0 5 5 5 0 Toluene-4-monooxygenase system protein B (TmoB) ACT_5 PF13710.6 ADV24874.1 - 1.3e-06 28.2 6.8 15 5.5 0.0 5.3 5 0 0 5 5 5 0 ACT domain UDP-g_GGTase PF06427.11 ADV24874.1 - 4.4e-06 26.8 6.0 9.6 6.4 0.0 4.9 5 0 0 5 5 5 0 UDP-glucose:Glycoprotein Glucosyltransferase DUF969 PF06149.12 ADV24874.1 - 2.4e-05 23.9 0.1 29 4.0 0.0 4.8 5 0 0 5 5 5 0 Protein of unknown function (DUF969) ACT_4 PF13291.6 ADV24874.1 - 0.00012 22.6 2.3 97 3.7 0.0 5.2 5 0 0 5 5 5 0 ACT domain DUF493 PF04359.14 ADV24874.1 - 0.00037 21.0 0.1 1.9e+02 2.7 0.0 4.9 5 0 0 5 5 5 0 Protein of unknown function (DUF493) ORF11CD3 PF10549.9 ADV24874.1 - 0.00069 19.7 0.0 1.2e+02 2.9 0.0 5.1 5 0 0 5 5 5 0 ORF11CD3 domain ProRS-C_2 PF09181.10 ADV24874.1 - 0.014 15.5 8.6 85 3.4 0.1 5.1 5 0 0 5 5 5 0 Prolyl-tRNA synthetase, C-terminal Tash_PEST PF07708.11 ADV24874.1 - 0.19 11.9 36.0 8 6.8 1.4 5.3 5 0 0 5 5 5 0 Tash protein PEST motif FlgD_ig PF13860.6 ADV24874.1 - 0.2 11.5 13.5 57 3.7 0.1 5.3 5 0 0 5 5 5 0 FlgD Ig-like domain YcgR_2 PF12945.7 ADV24874.1 - 0.42 10.8 8.1 38 4.5 0.1 4.9 5 0 0 5 5 5 0 Flagellar protein YcgR Phage_sheath_1N PF17481.2 ADV24874.1 - 0.92 10.0 12.8 1e+02 3.5 0.1 4.9 1 1 4 5 5 5 0 Phage tail sheath protein beta-sandwich domain PI3K_p85B PF02192.16 ADV24874.1 - 3.4 7.5 12.8 1.3e+02 2.5 0.1 5.1 5 0 0 5 5 5 0 PI3-kinase family, p85-binding domain Cnl2_NKP2 PF09447.10 ADV24874.1 - 6.4 7.0 14.2 1.3e+02 2.8 0.1 5.2 5 0 0 5 5 5 0 Cnl2/NKP2 family protein Ribosomal_S4e PF00900.20 ADV24874.1 - 7.9 6.5 11.8 1.7e+02 2.2 0.1 5.5 5 0 0 5 5 5 0 Ribosomal family S4e Cyclin PF08613.11 ADV24875.1 - 2.5e-25 89.7 0.0 3.4e-25 89.3 0.0 1.3 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 ADV24875.1 - 0.15 11.8 0.2 0.24 11.1 0.2 1.5 1 1 0 1 1 1 0 Cyclin, N-terminal domain Creatinase_N_2 PF16189.5 ADV24876.1 - 9.9e-48 162.3 0.6 2.2e-45 154.7 0.3 2.8 2 1 0 2 2 2 2 Creatinase/Prolidase N-terminal domain Peptidase_M24 PF00557.24 ADV24876.1 - 1.9e-44 151.9 0.0 2.9e-44 151.3 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 Peptidase_M24_C PF16188.5 ADV24876.1 - 4.8e-23 81.0 0.0 1.5e-22 79.4 0.0 1.9 1 0 0 1 1 1 1 C-terminal region of peptidase_M24 Creatinase_N PF01321.18 ADV24876.1 - 6.1e-23 81.9 0.0 4.1e-20 72.8 0.0 2.5 2 0 0 2 2 2 2 Creatinase/Prolidase N-terminal domain ROS_MUCR PF05443.11 ADV24880.1 - 0.098 12.7 1.0 0.19 11.8 1.0 1.4 1 0 0 1 1 1 0 ROS/MUCR transcriptional regulator protein TetR_C_21 PF17926.1 ADV24880.1 - 0.68 10.1 8.8 0.34 11.1 6.2 1.9 1 1 1 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Pkinase PF00069.25 ADV24883.1 - 8.5e-66 222.0 0.3 1.8e-64 217.7 0.3 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV24883.1 - 6.9e-36 123.9 0.0 1.5e-34 119.5 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.19 ADV24883.1 - 1.4e-17 63.2 0.2 2.7e-17 62.3 0.2 1.5 1 0 0 1 1 1 1 Kinase associated domain 1 Haspin_kinase PF12330.8 ADV24883.1 - 8.6e-08 31.5 0.1 1.4e-07 30.8 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 ADV24883.1 - 1.2e-07 31.4 0.0 2e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 ADV24883.1 - 3.2e-06 26.7 0.2 5.8e-06 25.8 0.2 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ADV24883.1 - 0.00045 20.2 0.0 0.0054 16.7 0.0 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 ADV24883.1 - 0.0034 17.0 0.1 0.007 16.0 0.1 1.5 1 0 0 1 1 1 1 RIO1 family YrbL-PhoP_reg PF10707.9 ADV24883.1 - 0.03 13.9 0.0 0.07 12.6 0.0 1.6 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Choline_kinase PF01633.20 ADV24883.1 - 0.065 12.8 2.7 0.57 9.7 2.7 2.1 1 1 0 1 1 1 0 Choline/ethanolamine kinase Pkinase_fungal PF17667.1 ADV24883.1 - 0.07 11.9 0.0 0.14 10.9 0.0 1.6 1 0 0 1 1 1 0 Fungal protein kinase Seadorna_VP7 PF07387.11 ADV24883.1 - 0.24 10.4 0.0 0.42 9.6 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 AhpC-TSA_2 PF13911.6 ADV24884.1 - 1e-26 93.3 0.0 1.8e-26 92.5 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme AhpC-TSA PF00578.21 ADV24884.1 - 0.00032 20.6 0.0 0.0042 17.0 0.0 2.1 2 0 0 2 2 2 1 AhpC/TSA family Redoxin PF08534.10 ADV24884.1 - 0.0081 15.9 0.0 0.027 14.2 0.0 1.7 2 0 0 2 2 2 1 Redoxin ATP-synt_E_2 PF08112.11 ADV24884.1 - 0.77 10.1 2.9 1.7 9.0 2.9 1.5 1 0 0 1 1 1 0 ATP synthase epsilon subunit Ribosomal_S19 PF00203.21 ADV24885.1 - 4.1e-26 90.7 0.0 5.1e-26 90.4 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S19 SKG6 PF08693.10 ADV24886.1 - 0.015 14.7 0.2 0.036 13.5 0.2 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain GOLD_2 PF13897.6 ADV24886.1 - 0.1 13.1 0.1 0.23 12.0 0.1 1.5 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking AIM5 PF17050.5 ADV24887.1 - 1.6e-08 35.2 0.1 4.1e-08 33.9 0.0 1.7 2 0 0 2 2 2 1 Altered inheritance of mitochondria 5 ECM11 PF15463.6 ADV24887.1 - 0.027 15.1 0.0 0.039 14.5 0.0 1.3 1 0 0 1 1 1 0 Extracellular mutant protein 11 Voltage_CLC PF00654.20 ADV24888.1 - 2.5e-90 303.3 28.0 2.5e-90 303.3 28.0 1.5 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 ADV24888.1 - 3.2e-09 37.1 1.0 9.2e-06 26.0 0.1 2.6 2 0 0 2 2 2 2 CBS domain zf-C3H1 PF10650.9 ADV24889.1 - 0.00049 19.8 0.1 0.00095 18.8 0.1 1.5 1 0 0 1 1 1 1 Putative zinc-finger domain YL1 PF05764.13 ADV24889.1 - 0.0015 18.7 9.3 0.0015 18.7 9.3 2.9 3 0 0 3 3 3 1 YL1 nuclear protein CENP-B_dimeris PF09026.10 ADV24889.1 - 0.18 12.2 4.2 0.52 10.7 4.2 1.8 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Cwf_Cwc_15 PF04889.12 ADV24889.1 - 2.6 7.7 19.5 0.021 14.6 8.0 3.0 3 0 0 3 3 3 0 Cwf15/Cwc15 cell cycle control protein Actin PF00022.19 ADV24890.1 - 1.1e-43 149.4 0.0 1.3e-24 86.5 0.0 2.2 2 0 0 2 2 2 2 Actin PrmC_N PF17827.1 ADV24890.1 - 2.8 8.6 5.5 1 10.0 1.6 2.4 2 0 0 2 2 2 0 PrmC N-terminal domain Mito_carr PF00153.27 ADV24891.1 - 1.5e-33 114.6 1.5 9.1e-16 57.6 0.1 3.5 3 1 1 4 4 4 3 Mitochondrial carrier protein BAG PF02179.16 ADV24892.1 - 1.3e-09 38.3 0.5 3.9e-09 36.8 0.0 2.0 2 0 0 2 2 2 1 BAG domain GREB1 PF15782.5 ADV24892.1 - 5.6 4.0 13.7 7.5 3.5 13.7 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SOG2 PF10428.9 ADV24892.1 - 9.3 5.3 22.0 13 4.8 22.0 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein Pirin PF02678.16 ADV24893.1 - 1.8e-31 108.3 0.1 5.2e-31 106.8 0.0 1.8 2 0 0 2 2 2 1 Pirin Pirin_C PF05726.13 ADV24893.1 - 3.3e-22 78.8 0.0 6.9e-22 77.8 0.0 1.6 1 0 0 1 1 1 1 Pirin C-terminal cupin domain Cupin_2 PF07883.11 ADV24893.1 - 0.00054 19.6 1.4 0.023 14.4 0.4 2.8 3 0 0 3 3 3 1 Cupin domain LSM PF01423.22 ADV24894.1 - 5.4e-10 38.8 0.0 8.5e-10 38.2 0.0 1.4 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 ADV24894.1 - 4.4e-05 23.5 0.0 7.1e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Ataxin 2 SM domain MBA1 PF07961.11 ADV24895.1 - 7.9e-08 31.6 0.3 1.2e-07 31.1 0.3 1.2 1 0 0 1 1 1 1 MBA1-like protein Ecl1 PF12855.7 ADV24896.1 - 8.8e-07 30.2 7.6 8.8e-07 30.2 7.6 4.6 1 1 3 4 4 4 1 ECL1/2/3 zinc binding proteins PLATZ PF04640.14 ADV24896.1 - 0.044 14.4 0.7 0.1 13.2 0.7 1.6 1 0 0 1 1 1 0 PLATZ transcription factor Opiods_neuropep PF01160.18 ADV24896.1 - 0.21 11.7 2.0 0.44 10.7 2.0 1.5 1 0 0 1 1 1 0 Vertebrate endogenous opioids neuropeptide MutS_V PF00488.21 ADV24897.1 - 1.6e-59 201.1 0.0 3.5e-59 200.0 0.0 1.6 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 ADV24897.1 - 3.7e-29 102.3 11.5 7e-27 94.9 13.2 3.0 3 1 0 3 3 3 1 MutS domain III MutS_I PF01624.20 ADV24897.1 - 9e-20 71.0 0.0 3.5e-19 69.1 0.0 2.1 2 0 0 2 2 2 1 MutS domain I MutS_II PF05188.17 ADV24897.1 - 3.4e-08 33.8 0.2 2e-07 31.4 0.0 2.4 2 0 0 2 2 2 1 MutS domain II MutS_IV PF05190.18 ADV24897.1 - 0.00021 21.6 0.1 0.00061 20.1 0.1 1.8 1 0 0 1 1 1 1 MutS family domain IV AAA_27 PF13514.6 ADV24897.1 - 0.0039 16.8 0.0 0.013 15.1 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_23 PF13476.6 ADV24897.1 - 0.023 15.2 9.7 0.36 11.3 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 ADV24897.1 - 0.037 14.1 0.0 0.17 11.9 0.0 2.1 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 ADV24897.1 - 0.081 12.7 0.1 0.21 11.4 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain MDM31_MDM32 PF08118.11 ADV24898.1 - 2.7e-180 600.5 0.0 3.2e-180 600.3 0.0 1.0 1 0 0 1 1 1 1 Yeast mitochondrial distribution and morphology (MDM) proteins DFRP_C PF16543.5 ADV24899.1 - 8.9e-28 96.6 1.4 8.9e-28 96.6 1.4 4.0 4 1 0 4 4 4 1 DRG Family Regulatory Proteins, Tma46 zf-CCCH_4 PF18044.1 ADV24899.1 - 2e-05 24.3 12.4 0.00018 21.2 2.5 3.4 3 0 0 3 3 3 2 CCCH-type zinc finger zf_CCCH_4 PF18345.1 ADV24899.1 - 8.4e-05 22.5 6.8 8.4e-05 22.5 6.8 3.3 3 0 0 3 3 3 2 Zinc finger domain zf-CCCH PF00642.24 ADV24899.1 - 0.0017 18.2 1.7 0.0017 18.2 1.7 2.1 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 ADV24899.1 - 0.0028 18.3 20.6 0.011 16.4 7.6 4.0 1 1 2 3 3 3 2 Torus domain zf-CCCH_2 PF14608.6 ADV24899.1 - 0.012 16.0 11.9 0.39 11.3 4.1 2.9 2 1 0 2 2 2 0 RNA-binding, Nab2-type zinc finger zf-CCCH_3 PF15663.5 ADV24899.1 - 1.7 8.9 12.6 0.59 10.4 1.7 2.9 2 1 0 3 3 3 0 Zinc-finger containing family PX PF00787.24 ADV24900.1 - 1.6e-17 63.5 0.0 2.9e-17 62.7 0.0 1.4 1 0 0 1 1 1 1 PX domain Tropomyosin PF00261.20 ADV24900.1 - 0.57 9.5 12.5 1.9 7.8 0.8 2.1 2 0 0 2 2 2 0 Tropomyosin DUF745 PF05335.13 ADV24900.1 - 0.77 9.4 9.3 1.9 8.1 4.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF745) V-SNARE_C PF12352.8 ADV24900.1 - 1 9.7 7.3 1.1 9.5 6.1 1.8 2 0 0 2 2 2 0 Snare region anchored in the vesicle membrane C-terminus DUF16 PF01519.16 ADV24900.1 - 1.2 9.6 6.4 9.6 6.8 4.4 2.3 2 0 0 2 2 2 0 Protein of unknown function DUF16 Snapin_Pallidin PF14712.6 ADV24900.1 - 1.3 9.5 10.3 0.66 10.4 6.7 2.3 2 0 0 2 2 2 0 Snapin/Pallidin DUF1664 PF07889.12 ADV24900.1 - 6 6.9 7.1 4.3 7.4 2.7 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) NAD_binding_10 PF13460.6 ADV24901.1 - 1.3e-09 38.3 0.0 1.9e-09 37.7 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 ADV24901.1 - 0.00018 21.1 0.0 0.0003 20.4 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family Polysacc_synt_2 PF02719.15 ADV24901.1 - 0.00059 19.1 0.0 0.00088 18.5 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 ADV24901.1 - 0.0069 15.6 0.0 0.011 15.0 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein Sacchrp_dh_NADP PF03435.18 ADV24901.1 - 0.023 14.9 0.0 0.041 14.1 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain 3Beta_HSD PF01073.19 ADV24901.1 - 0.04 12.9 0.0 0.06 12.3 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Sel1 PF08238.12 ADV24902.1 - 3e-10 40.4 8.6 4.8e-05 23.9 0.3 4.2 4 0 0 4 4 4 2 Sel1 repeat Dynamin_N PF00350.23 ADV24903.1 - 0.042 13.9 0.1 0.11 12.5 0.1 1.6 1 0 0 1 1 1 0 Dynamin family Ribosomal_S15 PF00312.22 ADV24903.1 - 0.15 12.3 0.1 0.39 11.0 0.1 1.6 1 0 0 1 1 1 0 Ribosomal protein S15 Uds1 PF15456.6 ADV24903.1 - 0.25 11.5 2.2 0.7 10.1 2.2 1.7 1 0 0 1 1 1 0 Up-regulated During Septation Ribonuc_red_sm PF00268.21 ADV24906.1 - 7.6e-111 370.0 0.7 9.2e-111 369.8 0.7 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain Glyco_hydro_cc PF11790.8 ADV24908.1 - 1.3e-59 201.7 0.9 1.5e-59 201.5 0.9 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core Glyco_hydro_cc PF11790.8 ADV24909.1 - 7.8e-33 114.0 2.3 3.3e-32 112.0 2.3 1.7 1 1 0 1 1 1 1 Glycosyl hydrolase catalytic core MPS2 PF17060.5 ADV24909.1 - 0.061 12.6 0.7 4.4 6.5 0.0 2.1 2 0 0 2 2 2 0 Monopolar spindle protein 2 eIF3g PF12353.8 ADV24911.1 - 2.7e-38 131.2 0.3 3.8e-38 130.7 0.3 1.2 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G RRM_1 PF00076.22 ADV24911.1 - 3e-15 55.8 0.0 5.6e-15 54.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 ADV24911.1 - 0.048 13.9 0.1 2.2 8.5 0.1 2.6 2 1 1 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter RRM_5 PF13893.6 ADV24911.1 - 0.14 11.8 0.0 0.23 11.1 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pre-PUA PF17832.1 ADV24912.1 - 2.2e-20 73.1 0.8 2e-13 50.8 0.0 2.2 2 0 0 2 2 2 2 Pre-PUA-like domain PUA PF01472.20 ADV24912.1 - 2e-15 56.5 0.4 3.3e-15 55.8 0.4 1.3 1 0 0 1 1 1 1 PUA domain DUF1947 PF09183.10 ADV24912.1 - 0.085 13.2 0.0 0.19 12.0 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1947) AP3D1 PF06375.11 ADV24912.1 - 3.3 7.9 6.9 4.7 7.4 6.9 1.2 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 TPR_1 PF00515.28 ADV24913.1 - 3.1e-06 26.7 0.0 0.0013 18.4 0.0 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 ADV24913.1 - 3.5e-05 23.6 2.5 0.033 14.3 0.1 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 ADV24913.1 - 0.00078 19.7 0.0 0.023 15.1 0.0 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ADV24913.1 - 0.0035 17.5 0.0 0.02 15.1 0.0 2.4 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 ADV24913.1 - 0.0044 17.1 0.1 1.6 9.2 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 ADV24913.1 - 0.013 15.5 2.4 8.3 6.7 0.1 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_9 PF13371.6 ADV24913.1 - 0.016 15.3 2.3 0.056 13.6 2.3 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat NARP1 PF12569.8 ADV24913.1 - 0.022 13.7 1.8 0.045 12.7 0.1 1.9 1 1 0 2 2 2 0 NMDA receptor-regulated protein 1 TPR_10 PF13374.6 ADV24913.1 - 0.032 14.1 1.2 15 5.6 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 ADV24913.1 - 0.061 14.2 0.1 0.061 14.2 0.1 5.9 5 2 1 6 6 6 0 Tetratricopeptide repeat TPR_19 PF14559.6 ADV24913.1 - 0.28 11.7 0.1 0.28 11.7 0.1 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 ADV24913.1 - 0.99 10.2 3.0 48 4.9 0.0 4.3 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 ADV24913.1 - 1 9.7 9.7 0.16 12.3 0.4 4.4 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.28 ADV24914.1 - 0.00012 21.7 0.0 0.0021 17.8 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 ADV24914.1 - 0.00025 20.9 0.4 0.0032 17.4 0.1 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 ADV24914.1 - 0.00035 20.8 0.0 3.2 8.3 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 ADV24914.1 - 0.027 14.6 0.1 0.6 10.5 0.0 3.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 ADV24914.1 - 0.11 13.4 0.9 3.8 8.6 0.3 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_4 PF07721.14 ADV24914.1 - 2.5 9.0 5.0 0.58 10.9 0.8 2.3 3 0 0 3 3 3 0 Tetratricopeptide repeat Skp1_POZ PF03931.15 ADV24915.1 - 0.078 13.2 0.0 0.17 12.0 0.0 1.5 1 0 0 1 1 1 0 Skp1 family, tetramerisation domain Ribosomal_S16 PF00886.19 ADV24916.1 - 4.8e-25 87.4 0.1 7.3e-25 86.8 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S16 MMR_HSR1 PF01926.23 ADV24917.1 - 6e-13 48.9 0.0 1.3e-12 47.9 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ADV24917.1 - 3.6e-05 23.3 0.0 6e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B IIGP PF05049.13 ADV24917.1 - 5.6e-05 22.4 0.0 8.5e-05 21.8 0.0 1.2 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) AIG1 PF04548.16 ADV24917.1 - 0.00011 21.6 0.0 0.00021 20.7 0.0 1.4 1 0 0 1 1 1 1 AIG1 family RsgA_GTPase PF03193.16 ADV24917.1 - 0.00084 19.3 0.0 0.0018 18.2 0.0 1.5 1 1 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 ADV24917.1 - 0.04 14.3 0.0 0.1 13.0 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain Roc PF08477.13 ADV24917.1 - 0.057 13.6 0.0 0.28 11.4 0.0 2.0 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Herpes_UL47 PF03362.13 ADV24917.1 - 0.086 11.6 0.0 0.13 11.0 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus UL47 protein AAA_18 PF13238.6 ADV24917.1 - 0.092 13.3 0.3 0.25 11.9 0.3 1.7 1 0 0 1 1 1 0 AAA domain MitoNEET_N PF10660.9 ADV24917.1 - 0.1 12.6 1.0 0.21 11.6 1.0 1.5 1 0 0 1 1 1 0 Iron-containing outer mitochondrial membrane protein N-terminus Dynamin_N PF00350.23 ADV24917.1 - 0.11 12.6 1.4 0.27 11.3 0.1 2.1 2 1 1 3 3 3 0 Dynamin family FXR_C1 PF16096.5 ADV24918.1 - 0.019 15.1 0.0 0.087 13.0 0.0 2.0 2 0 0 2 2 2 0 Fragile X-related 1 protein C-terminal region 2 Na_Ca_ex PF01699.24 ADV24919.1 - 2.4e-33 115.2 34.7 1.2e-16 61.0 16.8 2.1 2 0 0 2 2 2 2 Sodium/calcium exchanger protein SR-25 PF10500.9 ADV24919.1 - 0.047 13.3 7.3 0.087 12.4 7.3 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein RPA43_OB PF17875.1 ADV24920.1 - 1.4e-21 77.4 0.0 1.4e-21 77.4 0.0 3.6 3 1 0 3 3 3 2 RPA43 OB domain in RNA Pol I SHS2_Rpb7-N PF03876.17 ADV24920.1 - 2.4e-06 27.8 0.0 4e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 DDRGK PF09756.9 ADV24920.1 - 0.0016 18.1 1.7 0.0016 18.1 1.7 2.5 3 0 0 3 3 3 1 DDRGK domain DDHD PF02862.17 ADV24920.1 - 0.056 13.6 0.5 0.056 13.6 0.5 2.2 2 0 0 2 2 2 0 DDHD domain Eapp_C PF10238.9 ADV24920.1 - 7 6.7 16.9 0.18 11.9 0.5 2.6 2 0 0 2 2 2 0 E2F-associated phosphoprotein TRAPPC10 PF12584.8 ADV24921.1 - 1.1e-16 60.9 0.0 3.2e-16 59.4 0.0 1.8 2 0 0 2 2 2 1 Trafficking protein particle complex subunit 10, TRAPPC10 ING PF12998.7 ADV24922.1 - 2e-07 31.5 0.0 3.2e-07 30.9 0.0 1.3 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 ADV24922.1 - 2.1e-05 24.3 6.5 3.4e-05 23.6 6.5 1.3 1 0 0 1 1 1 1 PHD-finger DUF1539 PF07560.11 ADV24922.1 - 0.03 14.4 0.0 0.058 13.5 0.0 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1539) PHD_2 PF13831.6 ADV24922.1 - 0.063 12.9 1.6 0.12 11.9 1.6 1.5 1 0 0 1 1 1 0 PHD-finger Baculo_PEP_C PF04513.12 ADV24922.1 - 0.22 11.6 0.1 0.37 10.8 0.1 1.3 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus SNO PF01174.19 ADV24923.1 - 5e-42 143.9 0.0 8.1e-34 117.1 0.0 2.0 2 0 0 2 2 2 2 SNO glutamine amidotransferase family GATase_3 PF07685.14 ADV24923.1 - 0.019 14.6 0.0 0.026 14.1 0.0 1.2 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain PALP PF00291.25 ADV24924.1 - 1.6e-63 214.9 0.2 2.2e-63 214.4 0.2 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Thr_dehydrat_C PF00585.18 ADV24924.1 - 1.9e-41 139.7 0.0 8.5e-23 79.9 0.0 3.4 3 0 0 3 3 3 3 C-terminal regulatory domain of Threonine dehydratase DUF1744 PF08490.12 ADV24925.1 - 2.1e-127 425.1 0.0 4.7e-127 423.9 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1744) DNA_pol_B_exo1 PF03104.19 ADV24925.1 - 2.5e-70 237.3 0.0 4.1e-70 236.6 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_B PF00136.21 ADV24925.1 - 4.4e-11 42.1 7.6 1.2e-10 40.8 1.3 3.9 1 1 1 2 2 2 1 DNA polymerase family B DNA_pol_B_exo2 PF10108.9 ADV24925.1 - 4.8e-08 33.0 0.0 1.3e-07 31.5 0.0 1.7 1 0 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.6 ADV24925.1 - 0.00013 22.0 0.0 0.00042 20.3 0.0 1.8 1 0 0 1 1 1 1 RNase_H superfamily RNA_POL_M_15KD PF02150.16 ADV24925.1 - 0.0021 17.9 0.7 0.23 11.4 0.0 2.7 2 0 0 2 2 2 1 RNA polymerases M/15 Kd subunit NAPRTase_C PF17956.1 ADV24925.1 - 0.0022 18.4 0.0 0.0086 16.5 0.0 2.0 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase C-terminal domain zf-RRPl_C4 PF17026.5 ADV24925.1 - 0.32 11.1 2.3 0.86 9.7 2.3 1.7 1 0 0 1 1 1 0 Putative ribonucleoprotein zinc-finger pf C4 type zf-RING_10 PF16685.5 ADV24925.1 - 1.2 9.3 3.0 3.3 7.9 3.0 1.7 1 0 0 1 1 1 0 zinc RING finger of MSL2 Lactonase PF10282.9 ADV24926.1 - 3.9e-36 125.0 0.0 3.7e-35 121.8 0.0 2.0 1 1 0 1 1 1 1 Lactonase, 7-bladed beta-propeller Cyclin PF08613.11 ADV24927.1 - 6.8e-14 52.5 0.0 9.5e-14 52.1 0.0 1.3 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 ADV24927.1 - 6.1e-05 22.8 0.0 9.7e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Peptidase_C54 PF03416.19 ADV24928.1 - 3.3e-97 325.2 0.0 4.6e-97 324.8 0.0 1.2 1 0 0 1 1 1 1 Peptidase family C54 FAD-oxidase_C PF02913.19 ADV24929.1 - 6.1e-58 196.4 0.0 7.9e-58 196.0 0.0 1.1 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 ADV24929.1 - 7.6e-35 119.7 0.1 1.3e-34 119.0 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain Relaxase PF03432.14 ADV24929.1 - 0.0077 15.9 0.0 0.013 15.2 0.0 1.2 1 0 0 1 1 1 1 Relaxase/Mobilisation nuclease domain SH3_1 PF00018.28 ADV24930.1 - 2e-17 62.5 0.0 2.5e-10 39.8 0.0 2.5 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.6 ADV24930.1 - 1.2e-12 47.5 0.0 3.6e-06 26.7 0.0 2.8 3 0 0 3 3 3 2 Variant SH3 domain SH3_2 PF07653.17 ADV24930.1 - 3.4e-09 36.2 0.0 0.00013 21.6 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain PX PF00787.24 ADV24930.1 - 2.3e-07 30.8 0.0 5.1e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 PX domain Myb_Cef PF11831.8 ADV24931.1 - 2.6e-56 190.9 4.1 2.6e-56 190.9 4.1 3.6 3 1 0 3 3 3 1 pre-mRNA splicing factor component Myb_DNA-binding PF00249.31 ADV24931.1 - 1.2e-21 76.6 5.3 5.5e-11 42.5 1.3 2.8 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ADV24931.1 - 1.8e-18 66.5 6.1 1.7e-12 47.4 2.9 2.9 2 1 1 3 3 3 2 Myb-like DNA-binding domain NMD3 PF04981.13 ADV24932.1 - 4.4e-80 268.7 1.5 5.9e-80 268.2 1.5 1.2 1 0 0 1 1 1 1 NMD3 family DUF1289 PF06945.13 ADV24932.1 - 0.00038 20.2 2.9 0.59 10.0 0.3 3.1 3 0 0 3 3 3 2 Protein of unknown function (DUF1289) DZR PF12773.7 ADV24932.1 - 0.018 15.0 4.6 5.7 7.0 4.6 2.9 1 1 0 1 1 1 0 Double zinc ribbon TT_ORF2 PF02957.15 ADV24932.1 - 0.18 12.7 6.2 6.2 7.8 4.4 2.6 2 0 0 2 2 2 0 TT viral ORF2 Peptidase_C97 PF05903.14 ADV24933.1 - 8.3e-44 149.1 0.0 1.4e-43 148.3 0.0 1.4 1 0 0 1 1 1 1 PPPDE putative peptidase domain PUL PF08324.11 ADV24933.1 - 4.9e-39 134.2 0.5 7.6e-39 133.6 0.5 1.3 1 0 0 1 1 1 1 PUL domain Thioredoxin PF00085.20 ADV24933.1 - 1.9e-15 56.7 0.0 3.8e-15 55.7 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 ADV24933.1 - 9e-06 26.1 0.0 3.1e-05 24.4 0.0 1.9 1 1 0 1 1 1 1 Thioredoxin-like domain OST3_OST6 PF04756.13 ADV24933.1 - 8.8e-05 22.0 0.0 0.00014 21.4 0.0 1.2 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Pkinase PF00069.25 ADV24934.1 - 2.7e-68 230.2 0.0 3.9e-68 229.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV24934.1 - 4.7e-36 124.4 0.0 7.6e-36 123.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Fungal_KA1 PF16797.5 ADV24934.1 - 8.3e-14 51.3 0.1 1.6e-13 50.3 0.1 1.4 1 0 0 1 1 1 1 Fungal kinase associated-1 domain Kinase-like PF14531.6 ADV24934.1 - 4.8e-06 26.1 0.0 7.5e-06 25.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 ADV24934.1 - 0.0037 17.2 0.2 0.01 15.7 0.1 1.7 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 ADV24934.1 - 0.018 14.4 0.0 0.037 13.4 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 ADV24934.1 - 0.061 12.9 0.2 0.14 11.8 0.2 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase Haspin_kinase PF12330.8 ADV24934.1 - 0.12 11.3 0.1 0.2 10.6 0.1 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Phage_GP20 PF06810.11 ADV24935.1 - 0.0036 17.1 1.1 0.0049 16.7 1.1 1.2 1 0 0 1 1 1 1 Phage minor structural protein GP20 Sec2p PF06428.11 ADV24935.1 - 0.0098 15.8 2.6 0.016 15.1 2.6 1.3 1 0 0 1 1 1 1 GDP/GTP exchange factor Sec2p DUF3573 PF12097.8 ADV24935.1 - 0.024 13.5 0.1 0.026 13.3 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) API5 PF05918.11 ADV24935.1 - 0.039 12.8 0.2 0.043 12.6 0.2 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) NLRC4_HD2 PF17776.1 ADV24935.1 - 0.066 13.8 0.9 0.11 13.1 0.9 1.4 1 0 0 1 1 1 0 NLRC4 helical domain HD2 FlaC_arch PF05377.11 ADV24935.1 - 0.37 11.2 2.3 0.55 10.7 0.5 2.0 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Pkinase PF00069.25 ADV24936.1 - 3.7e-15 56.0 0.0 2.5e-14 53.3 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain HEAT PF02985.22 ADV24936.1 - 5.4e-12 44.9 2.0 0.0029 17.7 0.0 5.4 5 0 0 5 5 5 4 HEAT repeat HEAT_2 PF13646.6 ADV24936.1 - 1e-07 32.3 0.1 0.0081 16.5 0.0 4.5 3 2 2 5 5 5 3 HEAT repeats WD40 PF00400.32 ADV24936.1 - 6.8e-07 29.9 9.5 1.4e-05 25.7 0.1 5.0 6 0 0 6 6 5 1 WD domain, G-beta repeat Pkinase_Tyr PF07714.17 ADV24936.1 - 3.4e-05 23.3 0.0 0.034 13.4 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Cnd1 PF12717.7 ADV24936.1 - 0.00022 21.3 0.9 0.071 13.1 0.1 3.4 1 1 2 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 ADV24936.1 - 0.00032 21.1 0.2 0.023 15.2 0.0 3.1 2 0 0 2 2 2 1 HEAT-like repeat RTP1_C1 PF10363.9 ADV24936.1 - 0.0013 18.9 0.2 0.0092 16.2 0.1 2.3 2 0 0 2 2 2 1 Required for nuclear transport of RNA pol II C-terminus 1 Kinase-like PF14531.6 ADV24936.1 - 0.068 12.5 0.0 0.14 11.4 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Tti2 PF10521.9 ADV24936.1 - 0.091 12.3 0.0 0.2 11.2 0.0 1.5 1 0 0 1 1 1 0 Tti2 family DUF2639 PF11121.8 ADV24936.1 - 0.19 11.8 0.1 0.47 10.5 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2639) DUF3580 PF12117.8 ADV24936.1 - 0.94 9.7 4.8 0.41 10.9 1.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3580) His_Phos_2 PF00328.22 ADV24937.1 - 2.7e-36 125.8 0.0 3.9e-36 125.2 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Amnionless PF14828.6 ADV24938.1 - 0.14 11.0 0.0 0.14 11.0 0.0 2.2 1 1 2 3 3 3 0 Amnionless Fasciclin PF02469.22 ADV24939.1 - 1e-30 106.6 0.4 5.2e-17 62.3 0.1 3.2 3 0 0 3 3 3 3 Fasciclin domain Glyoxalase PF00903.25 ADV24939.1 - 0.015 15.5 0.8 0.015 15.5 0.8 2.2 2 0 0 2 2 2 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Cys_Met_Meta_PP PF01053.20 ADV24940.1 - 9.3e-119 396.4 0.0 1.3e-118 395.9 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme GHMP_kinases_N PF00288.26 ADV24940.1 - 1.9e-14 53.6 0.5 8.8e-14 51.5 0.5 2.3 1 0 0 1 1 1 1 GHMP kinases N terminal domain Aminotran_1_2 PF00155.21 ADV24940.1 - 1.9e-06 27.3 0.0 3.2e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II GHMP_kinases_C PF08544.13 ADV24940.1 - 2e-05 24.9 0.2 0.00019 21.8 0.1 2.7 2 1 0 2 2 2 1 GHMP kinases C terminal Met_gamma_lyase PF06838.11 ADV24940.1 - 0.0013 17.3 0.0 0.0021 16.6 0.0 1.2 1 0 0 1 1 1 1 Methionine gamma-lyase GalKase_gal_bdg PF10509.9 ADV24940.1 - 0.022 14.3 0.0 0.04 13.5 0.0 1.5 1 0 0 1 1 1 0 Galactokinase galactose-binding signature GDC-P PF02347.16 ADV24940.1 - 0.16 10.8 0.0 0.26 10.1 0.0 1.2 1 0 0 1 1 1 0 Glycine cleavage system P-protein OGFr_N PF04664.13 ADV24941.1 - 9.6e-73 244.1 0.6 1.3e-72 243.7 0.6 1.1 1 0 0 1 1 1 1 Opioid growth factor receptor (OGFr) conserved region Nitroreductase PF00881.24 ADV24942.1 - 1.9e-10 41.0 0.0 2.4e-10 40.7 0.0 1.1 1 0 0 1 1 1 1 Nitroreductase family ComK PF06338.11 ADV24942.1 - 0.11 12.2 0.1 0.18 11.4 0.1 1.3 1 0 0 1 1 1 0 ComK protein Sec3_C PF09763.9 ADV24943.1 - 3.7e-186 620.6 19.2 4.9e-186 620.2 19.2 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec3 Sec3-PIP2_bind PF15277.6 ADV24943.1 - 3e-21 75.3 0.1 6.2e-21 74.3 0.1 1.6 1 0 0 1 1 1 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH Sigma54_AID PF00309.20 ADV24943.1 - 0.1 12.4 3.0 0.33 10.9 3.0 1.9 1 0 0 1 1 1 0 Sigma-54 factor, Activator interacting domain (AID) Velvet PF11754.8 ADV24944.1 - 8.6e-46 156.9 0.0 8.6e-46 156.9 0.0 2.4 3 0 0 3 3 3 1 Velvet factor SGT1 PF07093.11 ADV24945.1 - 5.8e-100 335.4 0.0 5.8e-100 335.4 0.0 2.8 3 1 1 4 4 4 2 SGT1 protein zf-C2H2_jaz PF12171.8 ADV24946.1 - 1.1e-05 25.6 16.1 0.055 13.8 0.5 3.9 4 0 0 4 4 4 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 ADV24946.1 - 0.021 15.2 18.6 0.2 12.1 0.3 4.8 5 0 0 5 5 5 0 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 ADV24946.1 - 0.087 12.9 13.3 0.55 10.3 1.0 4.3 4 0 0 4 4 4 0 C2H2-type zinc finger zf-C2H2_4 PF13894.6 ADV24946.1 - 0.45 11.5 0.1 0.37 11.8 1.8 4.9 5 0 0 5 5 5 0 C2H2-type zinc finger zf-C2H2_2 PF12756.7 ADV24946.1 - 6.3 7.2 11.5 3.3 8.1 0.0 3.5 2 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) BAG PF02179.16 ADV24947.1 - 1.5e-08 35.0 0.8 4.7e-08 33.4 0.0 2.3 2 0 0 2 2 2 1 BAG domain OTT_1508_deam PF14441.6 ADV24947.1 - 0.061 13.3 0.2 0.16 12.0 0.2 1.7 1 0 0 1 1 1 0 OTT_1508-like deaminase zf-CCCH PF00642.24 ADV24948.1 - 2.9e-08 33.4 2.4 4.7e-08 32.8 2.4 1.3 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 ADV24948.1 - 7.9e-07 28.9 5.5 1.4e-06 28.1 5.5 1.4 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH_4 PF18044.1 ADV24948.1 - 4.5e-05 23.1 2.0 7.3e-05 22.5 2.0 1.3 1 0 0 1 1 1 1 CCCH-type zinc finger zf-CCCH_2 PF14608.6 ADV24948.1 - 0.029 14.8 1.5 0.056 13.9 1.5 1.4 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger Torus PF16131.5 ADV24948.1 - 0.83 10.4 7.5 0.074 13.8 2.3 1.9 2 0 0 2 2 2 0 Torus domain Peptidase_S64 PF08192.11 ADV24948.1 - 6.2 5.2 11.4 10 4.4 11.4 1.2 1 0 0 1 1 1 0 Peptidase family S64 Prenylcys_lyase PF07156.14 ADV24950.1 - 4.4e-49 167.5 0.0 5.7e-49 167.1 0.0 1.1 1 0 0 1 1 1 1 Prenylcysteine lyase NAD_binding_8 PF13450.6 ADV24950.1 - 2.8e-09 37.1 0.1 7.4e-09 35.7 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 ADV24950.1 - 6e-06 25.8 0.1 8.6e-06 25.3 0.1 1.3 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase DAO PF01266.24 ADV24950.1 - 2.2e-05 24.2 0.6 0.016 14.8 0.2 2.3 2 1 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ADV24950.1 - 0.0002 20.7 0.0 0.13 11.5 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 ADV24950.1 - 0.019 14.2 0.1 0.91 8.7 0.1 2.2 2 0 0 2 2 2 0 Thi4 family Cpn60_TCP1 PF00118.24 ADV24951.1 - 1.5e-162 541.7 3.2 1.7e-162 541.5 3.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family APH PF01636.23 ADV24952.1 - 3.5e-10 40.2 0.0 2e-09 37.7 0.0 2.0 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 ADV24952.1 - 2e-07 30.6 0.0 0.00012 21.5 0.0 2.2 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 ADV24952.1 - 1.4e-06 27.9 0.0 4.1e-06 26.4 0.0 1.7 1 1 1 2 2 2 1 Protein kinase domain EcKinase PF02958.20 ADV24952.1 - 1.3e-05 24.7 0.0 1.7e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 Ecdysteroid kinase RIO1 PF01163.22 ADV24952.1 - 4e-05 23.3 0.0 0.13 11.9 0.0 2.2 2 0 0 2 2 2 2 RIO1 family Pkinase_Tyr PF07714.17 ADV24952.1 - 0.011 15.0 0.0 0.017 14.4 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase Pkinase_fungal PF17667.1 ADV24952.1 - 0.21 10.3 0.0 0.36 9.5 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase PI3_PI4_kinase PF00454.27 ADV24952.1 - 0.22 11.3 0.0 1.4 8.7 0.0 1.9 2 0 0 2 2 2 0 Phosphatidylinositol 3- and 4-kinase PCRF PF03462.18 ADV24954.1 - 1.6e-45 155.4 0.0 3.1e-45 154.4 0.0 1.5 1 0 0 1 1 1 1 PCRF domain RF-1 PF00472.20 ADV24954.1 - 1.5e-36 124.9 1.6 3.8e-36 123.6 1.6 1.6 1 0 0 1 1 1 1 RF-1 domain FYVE PF01363.21 ADV24955.1 - 8.6e-14 51.4 5.3 1.9e-13 50.4 5.3 1.5 1 0 0 1 1 1 1 FYVE zinc finger zf-AN1 PF01428.16 ADV24955.1 - 0.77 10.0 6.0 1.7 8.9 6.0 1.6 1 0 0 1 1 1 0 AN1-like Zinc finger Lactamase_B_2 PF12706.7 ADV24956.1 - 0.0013 18.3 0.1 0.0088 15.6 0.1 2.2 1 1 0 1 1 1 1 Beta-lactamase superfamily domain DRMBL PF07522.14 ADV24956.1 - 0.0096 16.1 0.0 0.029 14.6 0.0 1.8 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B_6 PF16661.5 ADV24956.1 - 0.087 12.3 0.0 0.25 10.8 0.0 1.7 2 0 0 2 2 2 0 Metallo-beta-lactamase superfamily domain DUF1088 PF06469.11 ADV24956.1 - 0.091 12.4 0.2 0.17 11.5 0.2 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1088) Lactamase_B PF00753.27 ADV24956.1 - 7.9 6.4 5.9 1.1e+02 2.7 5.9 2.4 1 1 0 1 1 1 0 Metallo-beta-lactamase superfamily Chromo PF00385.24 ADV24957.1 - 2.7e-10 40.0 0.1 5.9e-10 38.9 0.1 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain DUF1373 PF07117.11 ADV24957.1 - 0.035 14.1 0.3 0.035 14.1 0.3 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1373) Presenilin PF01080.17 ADV24957.1 - 0.25 10.1 4.5 0.043 12.6 1.1 1.4 2 0 0 2 2 2 0 Presenilin Pox_Ag35 PF03286.14 ADV24957.1 - 0.29 10.9 15.3 0.02 14.7 9.6 1.8 2 0 0 2 2 2 0 Pox virus Ag35 surface protein FAM176 PF14851.6 ADV24957.1 - 5.5 6.6 8.8 15 5.2 5.5 2.3 2 0 0 2 2 2 0 FAM176 family FYDLN_acid PF09538.10 ADV24957.1 - 8.1 7.2 13.6 7.5 7.3 10.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) SNF2_N PF00176.23 ADV24958.1 - 2.4e-21 75.8 0.2 2.2e-13 49.7 0.0 2.4 2 0 0 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.31 ADV24958.1 - 1.1e-06 29.0 0.0 1.5e-05 25.3 0.0 2.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ADV24958.1 - 0.0091 16.0 0.0 0.081 12.9 0.0 2.3 1 1 0 2 2 2 1 Type III restriction enzyme, res subunit TIP120 PF08623.10 ADV24959.1 - 1.1e-49 168.4 3.5 1.7e-48 164.6 0.4 3.6 3 1 0 3 3 3 1 TATA-binding protein interacting (TIP20) HEAT_2 PF13646.6 ADV24959.1 - 1.9e-08 34.5 17.3 0.45 10.9 0.0 9.1 6 3 5 11 11 11 2 HEAT repeats HEAT PF02985.22 ADV24959.1 - 9.1e-08 31.7 31.2 0.14 12.5 0.1 12.2 14 1 1 15 15 13 3 HEAT repeat Adaptin_N PF01602.20 ADV24959.1 - 4.9e-07 28.7 15.3 0.00011 20.9 3.0 4.5 6 1 0 6 6 6 2 Adaptin N terminal region Vac14_Fab1_bd PF12755.7 ADV24959.1 - 1.3e-06 28.9 1.8 0.23 12.1 0.0 5.7 5 1 1 6 6 6 2 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 ADV24959.1 - 2.7e-06 27.5 7.3 0.0012 18.9 0.8 5.3 3 2 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 ADV24959.1 - 1.2e-05 25.6 21.6 11 6.6 0.1 10.8 12 1 1 13 13 13 0 HEAT-like repeat Arm PF00514.23 ADV24959.1 - 0.0024 17.8 2.5 79 3.5 0.0 7.2 8 0 0 8 8 8 0 Armadillo/beta-catenin-like repeat RIX1 PF08167.12 ADV24959.1 - 0.016 14.9 14.4 0.96 9.2 0.1 6.1 6 2 0 6 6 6 0 rRNA processing/ribosome biogenesis V-ATPase_H_C PF11698.8 ADV24959.1 - 0.021 14.9 2.6 13 5.9 0.0 5.9 7 1 1 8 8 8 0 V-ATPase subunit H TAF6_C PF07571.13 ADV24959.1 - 0.029 14.7 0.4 2.4 8.5 0.0 3.8 3 1 0 3 3 3 0 TAF6 C-terminal HEAT repeat domain RTP1_C1 PF10363.9 ADV24959.1 - 0.03 14.5 5.7 58 3.9 0.0 6.0 7 1 0 7 7 7 0 Required for nuclear transport of RNA pol II C-terminus 1 Telomere_reg-2 PF10193.9 ADV24959.1 - 0.056 13.9 0.5 15 6.1 0.1 4.3 4 1 0 4 4 3 0 Telomere length regulation protein UPF0253 PF06786.12 ADV24959.1 - 0.13 12.5 0.4 2.6 8.4 0.3 2.9 3 0 0 3 3 2 0 Uncharacterised protein family (UPF0253) YL1 PF05764.13 ADV24959.1 - 0.39 10.8 3.5 0.71 10.0 3.5 1.4 1 0 0 1 1 1 0 YL1 nuclear protein Sigma70_ner PF04546.13 ADV24959.1 - 0.48 10.3 6.1 7.2 6.4 1.4 2.7 2 0 0 2 2 2 0 Sigma-70, non-essential region bZIP_1 PF00170.21 ADV24962.1 - 2.1e-07 30.9 14.5 2.1e-07 30.9 14.5 2.4 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 ADV24962.1 - 5.4e-07 29.6 15.5 5.4e-07 29.6 15.5 3.0 3 0 0 3 3 3 1 Basic region leucine zipper bZIP_Maf PF03131.17 ADV24962.1 - 0.025 15.1 9.0 0.025 15.1 9.0 3.5 4 1 1 5 5 5 0 bZIP Maf transcription factor GREB1 PF15782.5 ADV24962.1 - 0.23 8.6 11.3 0.34 8.0 11.3 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer HALZ PF02183.18 ADV24962.1 - 1.3 9.3 5.2 0.29 11.4 0.8 2.3 2 0 0 2 2 2 0 Homeobox associated leucine zipper 6PGD PF00393.19 ADV24963.1 - 6.1e-125 416.4 0.0 7.7e-125 416.1 0.0 1.1 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 ADV24963.1 - 2.3e-50 170.9 0.0 3.6e-50 170.2 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 ADV24963.1 - 0.0013 19.2 0.1 0.0027 18.3 0.1 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.19 ADV24963.1 - 0.15 11.4 0.0 0.38 10.1 0.0 1.6 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GIT_SHD PF08518.11 ADV24964.1 - 1.1e-23 82.5 8.2 8.8e-12 44.4 1.8 2.6 2 0 0 2 2 2 2 Spa2 homology domain (SHD) of GIT GIT1_C PF12205.8 ADV24964.1 - 0.0064 16.6 2.5 0.023 14.8 0.0 3.1 3 1 1 4 4 4 1 G protein-coupled receptor kinase-interacting protein 1 C term CENP-F_leu_zip PF10473.9 ADV24964.1 - 0.82 9.7 27.8 0.14 12.1 11.8 2.9 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Fib_alpha PF08702.10 ADV24964.1 - 3.3 7.9 6.7 3.3 7.9 1.3 2.9 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family BLOC1_2 PF10046.9 ADV24964.1 - 4.2 7.7 6.9 4.1 7.8 0.2 3.3 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4200 PF13863.6 ADV24964.1 - 4.3 7.8 28.1 1.2 9.5 11.4 3.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4200) DUF3053 PF11254.8 ADV24964.1 - 5.1 6.6 8.1 9.4 5.8 3.7 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3053) TFIID-31kDa PF02291.15 ADV24965.1 - 1.6e-34 118.6 0.0 2e-34 118.3 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 ADV24965.1 - 0.00083 19.3 0.0 0.0015 18.5 0.0 1.4 1 0 0 1 1 1 1 Bromodomain associated Adenylate_cycl PF01295.18 ADV24965.1 - 0.056 12.1 0.0 0.068 11.8 0.0 1.0 1 0 0 1 1 1 0 Adenylate cyclase, class-I Mg_chelatase_C PF13335.6 ADV24965.1 - 0.087 13.5 0.6 0.14 12.8 0.6 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI C-terminal SDA1 PF05285.12 ADV24965.1 - 6.8 6.0 10.4 2 7.8 7.1 1.6 2 0 0 2 2 2 0 SDA1 RNA_polI_A34 PF08208.11 ADV24966.1 - 1.7e-14 54.4 9.7 1.1e-09 38.7 8.1 3.1 3 0 0 3 3 3 2 DNA-directed RNA polymerase I subunit RPA34.5 muHD PF10291.9 ADV24967.1 - 4e-56 190.4 0.0 7.1e-56 189.6 0.0 1.4 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain FCH PF00611.23 ADV24967.1 - 5e-11 42.7 1.9 7.2e-11 42.2 0.1 2.2 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain VTC PF09359.10 ADV24967.1 - 0.056 12.8 0.1 0.094 12.1 0.1 1.2 1 0 0 1 1 1 0 VTC domain DUF3829 PF12889.7 ADV24967.1 - 0.11 11.9 0.6 0.31 10.5 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3829) Syntaxin PF00804.25 ADV24967.1 - 0.48 10.1 3.8 1.9 8.1 0.4 2.3 2 0 0 2 2 2 0 Syntaxin Methyltransf_23 PF13489.6 ADV24968.1 - 7.5e-24 84.4 0.0 1.1e-23 83.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ADV24968.1 - 8.1e-18 64.9 0.0 1.7e-17 63.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ADV24968.1 - 3.2e-14 53.0 0.0 4.8e-14 52.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ADV24968.1 - 5e-14 52.8 0.1 1.6e-13 51.2 0.1 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 ADV24968.1 - 6.9e-13 49.2 0.0 1.3e-12 48.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 ADV24968.1 - 2.3e-08 33.7 0.0 3.4e-08 33.1 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase PrmA PF06325.13 ADV24968.1 - 5.4e-06 26.0 0.0 8e-06 25.5 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_9 PF08003.11 ADV24968.1 - 0.00012 21.1 0.0 0.0002 20.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) DREV PF05219.12 ADV24968.1 - 0.0051 15.9 0.0 0.0087 15.2 0.0 1.3 1 0 0 1 1 1 1 DREV methyltransferase Ubie_methyltran PF01209.18 ADV24968.1 - 0.0052 16.1 0.0 0.0075 15.6 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 ADV24968.1 - 0.0072 15.9 0.1 0.015 14.9 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_32 PF13679.6 ADV24968.1 - 0.015 15.3 0.0 0.025 14.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain TPMT PF05724.11 ADV24968.1 - 0.019 14.6 0.0 0.034 13.8 0.0 1.4 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) NodS PF05401.11 ADV24968.1 - 0.035 13.7 0.0 0.077 12.6 0.0 1.5 1 1 0 1 1 1 0 Nodulation protein S (NodS) TehB PF03848.14 ADV24968.1 - 0.042 13.3 0.0 0.064 12.7 0.0 1.3 1 0 0 1 1 1 0 Tellurite resistance protein TehB DNA_ligase_A_M PF01068.21 ADV24969.1 - 1.3e-43 149.0 0.0 2.3e-43 148.2 0.0 1.4 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 ADV24969.1 - 2.9e-35 122.1 0.0 8.1e-35 120.7 0.0 1.8 1 0 0 1 1 1 1 DNA ligase N terminus BRCT_2 PF16589.5 ADV24969.1 - 2.6e-23 82.2 0.0 1.9e-11 44.2 0.0 2.9 3 0 0 3 3 3 2 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 ADV24969.1 - 3.4e-16 59.4 0.0 1.3e-08 35.1 0.0 2.7 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain RNA_ligase PF09414.10 ADV24969.1 - 1.3e-12 48.4 2.1 2.2e-11 44.4 0.3 2.9 3 0 0 3 3 3 1 RNA ligase LIG3_BRCT PF16759.5 ADV24969.1 - 3.5e-07 30.4 0.0 0.0029 17.9 0.0 2.5 2 0 0 2 2 2 2 DNA ligase 3 BRCT domain PTCB-BRCT PF12738.7 ADV24969.1 - 0.0016 18.3 0.0 1 9.3 0.0 2.8 2 0 0 2 2 2 2 twin BRCT domain RTT107_BRCT_5 PF16770.5 ADV24969.1 - 0.017 15.0 0.0 0.085 12.7 0.0 2.2 2 0 0 2 2 2 0 Regulator of Ty1 transposition protein 107 BRCT domain RabGAP-TBC PF00566.18 ADV24970.1 - 2.9e-55 187.3 0.4 4.1e-55 186.8 0.4 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain HORMA PF02301.18 ADV24971.1 - 1.3e-42 145.8 0.0 1.3e-42 145.8 0.0 2.2 3 0 0 3 3 3 1 HORMA domain PHD PF00628.29 ADV24971.1 - 2.1e-07 30.7 10.3 3.8e-07 29.9 10.3 1.5 1 0 0 1 1 1 1 PHD-finger Ndc1_Nup PF09531.10 ADV24971.1 - 0.053 12.2 15.4 0.0095 14.7 7.8 2.3 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup zf-piccolo PF05715.13 ADV24971.1 - 0.09 12.9 8.1 0.21 11.8 8.1 1.6 1 0 0 1 1 1 0 Piccolo Zn-finger PHD_2 PF13831.6 ADV24971.1 - 0.58 9.8 7.4 1.3 8.6 7.4 1.6 1 0 0 1 1 1 0 PHD-finger Fungal_trans PF04082.18 ADV24972.1 - 3.4e-22 78.8 1.4 6.1e-22 77.9 1.4 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2_4 PF13894.6 ADV24972.1 - 2.1e-06 28.1 7.7 0.012 16.4 1.4 3.4 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 ADV24972.1 - 1.3e-05 25.3 13.8 0.0018 18.6 2.4 3.3 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_8 PF15909.5 ADV24972.1 - 0.017 15.4 1.0 0.064 13.6 1.0 2.0 1 0 0 1 1 1 0 C2H2-type zinc ribbon zf-C2H2_6 PF13912.6 ADV24972.1 - 0.025 14.6 3.1 0.24 11.5 0.4 3.0 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2HE PF16278.5 ADV24972.1 - 0.068 13.6 4.6 0.074 13.5 0.5 2.4 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-H2C2_2 PF13465.6 ADV24972.1 - 0.13 12.7 9.7 0.34 11.4 0.9 3.1 3 0 0 3 3 3 0 Zinc-finger double domain zf-met PF12874.7 ADV24972.1 - 0.19 12.2 7.6 0.32 11.5 0.8 3.0 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 ADV24972.1 - 0.67 10.3 2.4 4.4 7.7 0.3 2.7 2 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) Ribonuc_L-PSP PF01042.21 ADV24973.1 - 2.7e-24 85.5 0.0 3.3e-24 85.2 0.0 1.1 1 0 0 1 1 1 1 Endoribonuclease L-PSP HpcH_HpaI PF03328.14 ADV24974.1 - 2.8e-34 118.2 0.0 3.5e-34 117.9 0.0 1.1 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family PEP-utilizers_C PF02896.18 ADV24974.1 - 0.00021 20.5 0.0 0.016 14.3 0.0 2.5 2 1 0 2 2 2 2 PEP-utilising enzyme, TIM barrel domain MFS_1 PF07690.16 ADV24975.1 - 5.8e-19 68.2 29.9 5.8e-19 68.2 29.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 ADV24975.1 - 7.7e-08 31.6 5.6 9.1e-06 24.8 5.6 3.2 1 1 0 1 1 1 1 MFS_1 like family TRI12 PF06609.13 ADV24975.1 - 1.6e-05 23.6 1.1 2.4e-05 23.0 1.1 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 ADV24975.1 - 0.0013 17.7 25.3 0.085 11.7 25.3 2.6 1 1 0 1 1 1 1 Sugar (and other) transporter Pyr_redox_2 PF07992.14 ADV24976.1 - 1.9e-13 50.3 0.0 2.9e-13 49.7 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ADV24976.1 - 8.7e-07 28.5 0.0 0.0019 17.5 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 ADV24976.1 - 9.5e-06 24.9 0.0 3.7e-05 23.0 0.0 1.9 2 1 0 3 3 3 1 FAD binding domain NAD_binding_9 PF13454.6 ADV24976.1 - 1.8e-05 24.8 0.4 0.0073 16.3 0.0 2.4 2 0 0 2 2 2 2 FAD-NAD(P)-binding HI0933_like PF03486.14 ADV24976.1 - 3.3e-05 22.8 0.0 0.0015 17.3 0.0 2.2 2 0 0 2 2 2 1 HI0933-like protein NAD_binding_8 PF13450.6 ADV24976.1 - 0.00023 21.4 0.0 0.00046 20.4 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 ADV24976.1 - 0.00036 20.2 0.5 0.0023 17.6 0.5 2.0 1 1 0 1 1 1 1 FAD dependent oxidoreductase K_oxygenase PF13434.6 ADV24976.1 - 0.005 16.0 0.1 0.48 9.5 0.0 2.1 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) FAD_oxidored PF12831.7 ADV24976.1 - 0.0075 15.7 1.9 0.018 14.4 0.0 2.3 2 1 1 3 3 3 1 FAD dependent oxidoreductase GIDA PF01134.22 ADV24976.1 - 0.0096 15.0 2.5 0.077 12.1 0.1 2.7 2 1 1 3 3 3 1 Glucose inhibited division protein A Lycopene_cycl PF05834.12 ADV24976.1 - 0.012 14.7 0.3 0.21 10.6 0.1 2.1 1 1 1 2 2 2 0 Lycopene cyclase protein FAD_binding_3 PF01494.19 ADV24976.1 - 0.026 13.8 0.0 0.035 13.3 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain AlaDh_PNT_C PF01262.21 ADV24976.1 - 0.038 13.3 0.0 0.071 12.4 0.0 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.17 ADV24976.1 - 0.15 11.3 0.0 0.31 10.3 0.0 1.5 1 0 0 1 1 1 0 Thi4 family Hva1_TUDOR PF11160.8 ADV24978.1 - 6.9e-07 29.3 0.1 8.7e-07 29.0 0.1 1.2 1 0 0 1 1 1 1 Hypervirulence associated proteins TUDOR domain HAS-barrel PF09378.10 ADV24978.1 - 0.028 14.6 0.0 0.031 14.4 0.0 1.1 1 0 0 1 1 1 0 HAS barrel domain TMPIT PF07851.13 ADV24979.1 - 0.58 9.4 1.9 0.84 8.8 1.9 1.2 1 0 0 1 1 1 0 TMPIT-like protein GBP_C PF02841.14 ADV24979.1 - 2 7.8 7.1 3.1 7.1 7.1 1.2 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain vWA-TerF-like PF10138.9 ADV24980.1 - 0.00043 20.4 0.0 0.00066 19.8 0.0 1.2 1 0 0 1 1 1 1 vWA found in TerF C terminus 2OG-FeII_Oxy_3 PF13640.6 ADV24981.1 - 1e-05 26.3 0.0 2.5e-05 25.1 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily AAA PF00004.29 ADV24982.1 - 5.2e-32 111.1 0.1 9.5e-32 110.2 0.1 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ADV24982.1 - 2.9e-07 30.9 0.3 8e-06 26.2 0.1 2.9 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 ADV24982.1 - 6.4e-07 29.9 0.3 5.8e-06 26.8 0.0 2.5 2 2 0 2 2 2 1 AAA ATPase domain AAA_2 PF07724.14 ADV24982.1 - 3.8e-06 27.1 1.2 5.4e-06 26.6 0.1 1.8 2 0 0 2 2 1 1 AAA domain (Cdc48 subfamily) AAA_18 PF13238.6 ADV24982.1 - 9.4e-06 26.2 0.3 3.3e-05 24.4 0.0 2.2 2 0 0 2 2 1 1 AAA domain AAA_25 PF13481.6 ADV24982.1 - 0.0001 21.9 0.0 0.11 12.1 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.6 ADV24982.1 - 0.00013 22.1 0.2 0.00043 20.4 0.2 2.0 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.6 ADV24982.1 - 0.00019 21.5 0.0 0.00057 19.9 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 ADV24982.1 - 0.0017 18.4 0.2 0.0057 16.7 0.2 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 ADV24982.1 - 0.0019 17.9 0.0 0.0041 16.9 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 ADV24982.1 - 0.002 18.5 0.0 0.0065 16.8 0.0 1.9 1 0 0 1 1 1 1 RNA helicase ABC_tran PF00005.27 ADV24982.1 - 0.0026 18.3 0.9 0.0072 16.8 0.0 2.2 3 0 0 3 3 1 1 ABC transporter ATPase_2 PF01637.18 ADV24982.1 - 0.0027 17.7 0.5 1.5 8.6 0.1 2.9 2 1 1 3 3 2 1 ATPase domain predominantly from Archaea Viral_helicase1 PF01443.18 ADV24982.1 - 0.003 17.4 0.0 0.0062 16.3 0.0 1.5 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase TsaE PF02367.17 ADV24982.1 - 0.0035 17.3 0.0 0.0084 16.1 0.0 1.6 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Cytidylate_kin PF02224.18 ADV24982.1 - 0.0036 17.1 0.1 0.011 15.4 0.0 1.9 2 0 0 2 2 1 1 Cytidylate kinase AAA_24 PF13479.6 ADV24982.1 - 0.0042 16.8 0.0 0.011 15.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 ADV24982.1 - 0.0066 16.3 1.3 0.0066 16.3 1.3 2.4 2 1 0 2 2 2 1 AAA domain NACHT PF05729.12 ADV24982.1 - 0.0068 16.3 0.3 0.032 14.1 0.3 2.3 1 1 0 1 1 1 1 NACHT domain DUF815 PF05673.13 ADV24982.1 - 0.0072 15.5 0.1 0.051 12.7 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_28 PF13521.6 ADV24982.1 - 0.0081 16.4 2.9 0.0086 16.3 0.0 2.5 3 0 0 3 3 3 1 AAA domain IstB_IS21 PF01695.17 ADV24982.1 - 0.0094 15.7 0.0 0.021 14.6 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_19 PF13245.6 ADV24982.1 - 0.011 16.0 0.9 0.21 11.9 0.0 2.7 2 1 0 3 3 3 0 AAA domain TIP49 PF06068.13 ADV24982.1 - 0.013 14.7 0.0 0.013 14.7 0.0 1.7 2 0 0 2 2 2 0 TIP49 P-loop domain AAA_13 PF13166.6 ADV24982.1 - 0.019 13.7 0.0 0.054 12.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 ADV24982.1 - 0.023 14.4 1.5 0.029 14.1 0.0 2.0 2 1 0 2 2 1 0 AAA domain AAA_17 PF13207.6 ADV24982.1 - 0.03 14.8 0.1 0.15 12.5 0.1 2.3 1 1 1 2 2 2 0 AAA domain ATPase PF06745.13 ADV24982.1 - 0.033 13.5 1.3 1.8 7.9 0.0 3.2 2 1 1 3 3 3 0 KaiC KAP_NTPase PF07693.14 ADV24982.1 - 0.037 13.3 0.0 2.2 7.4 0.0 2.3 1 1 1 2 2 2 0 KAP family P-loop domain PduV-EutP PF10662.9 ADV24982.1 - 0.042 13.6 0.0 0.089 12.5 0.0 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation U79_P34 PF03064.16 ADV24982.1 - 0.047 13.1 0.4 0.047 13.1 0.4 1.8 2 0 0 2 2 2 0 HSV U79 / HCMV P34 Rad17 PF03215.15 ADV24982.1 - 0.057 13.3 0.0 0.14 12.1 0.0 1.7 1 0 0 1 1 1 0 Rad17 P-loop domain Mg_chelatase PF01078.21 ADV24982.1 - 0.075 12.4 0.0 0.17 11.3 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI PhoH PF02562.16 ADV24982.1 - 0.084 12.3 0.0 0.3 10.5 0.0 1.8 2 0 0 2 2 2 0 PhoH-like protein AAA_7 PF12775.7 ADV24982.1 - 0.088 12.3 0.0 0.17 11.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Rad51 PF08423.11 ADV24982.1 - 0.091 12.0 0.3 11 5.2 0.0 2.2 1 1 0 2 2 2 0 Rad51 AAA_23 PF13476.6 ADV24982.1 - 0.12 12.9 2.1 0.25 11.8 0.2 2.5 2 1 0 2 2 2 0 AAA domain AAA_3 PF07726.11 ADV24982.1 - 0.12 12.2 0.0 0.37 10.7 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Ras PF00071.22 ADV24983.1 - 1.4e-56 190.5 0.1 1.7e-56 190.3 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ADV24983.1 - 1.5e-31 109.1 0.0 2.3e-31 108.5 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ADV24983.1 - 9.6e-14 51.2 0.0 1.1e-13 51.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ADV24983.1 - 9.3e-08 32.1 0.0 1.6e-07 31.4 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ADV24983.1 - 3e-06 26.8 0.0 3.7e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 ADV24983.1 - 3.1e-06 26.9 0.1 0.00014 21.4 0.0 2.2 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ADV24983.1 - 4.6e-05 23.4 0.0 0.0037 17.2 0.0 2.3 2 1 0 2 2 2 1 RsgA GTPase PduV-EutP PF10662.9 ADV24983.1 - 0.0011 18.8 0.1 0.14 11.9 0.0 2.2 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation ATP_bind_1 PF03029.17 ADV24983.1 - 0.0016 18.3 0.2 0.067 13.0 0.0 2.1 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein AAA_16 PF13191.6 ADV24983.1 - 0.002 18.6 0.0 0.0038 17.6 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ADV24983.1 - 0.0069 16.7 0.0 0.012 15.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain cobW PF02492.19 ADV24983.1 - 0.013 15.1 0.0 0.037 13.6 0.0 1.7 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_7 PF12775.7 ADV24983.1 - 0.014 14.9 0.1 0.021 14.4 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Septin PF00735.18 ADV24983.1 - 0.014 14.7 0.2 0.098 11.9 0.0 2.1 2 1 0 2 2 2 0 Septin AAA_24 PF13479.6 ADV24983.1 - 0.019 14.7 0.0 0.042 13.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain SRPRB PF09439.10 ADV24983.1 - 0.02 14.3 0.0 0.027 13.9 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_5 PF07728.14 ADV24983.1 - 0.027 14.4 0.0 0.07 13.1 0.0 1.7 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) ATPase_2 PF01637.18 ADV24983.1 - 0.041 13.8 0.3 0.077 12.9 0.0 1.5 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea TniB PF05621.11 ADV24983.1 - 0.042 13.2 0.0 0.06 12.7 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein DAP3 PF10236.9 ADV24983.1 - 0.095 11.8 0.4 0.15 11.2 0.1 1.5 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 NACHT PF05729.12 ADV24983.1 - 0.1 12.5 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 NACHT domain NB-ARC PF00931.22 ADV24983.1 - 0.12 11.6 0.5 0.25 10.5 0.5 1.5 1 1 0 1 1 1 0 NB-ARC domain ABC_tran PF00005.27 ADV24983.1 - 0.19 12.3 0.0 0.4 11.2 0.0 1.6 2 0 0 2 2 2 0 ABC transporter DUF3760 PF12586.8 ADV24984.1 - 2.2e-10 40.5 0.8 4.9e-10 39.4 0.8 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3760) GST_C_6 PF17171.4 ADV24985.1 - 0.00013 21.7 0.0 0.00029 20.6 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 ADV24985.1 - 0.0077 16.2 0.6 0.014 15.4 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain Tom37 PF10568.9 ADV24985.1 - 0.013 15.8 0.0 0.024 14.9 0.0 1.4 1 0 0 1 1 1 0 Outer mitochondrial membrane transport complex protein Tom37_C PF11801.8 ADV24985.1 - 0.043 13.8 0.0 0.07 13.1 0.0 1.3 1 0 0 1 1 1 0 Tom37 C-terminal domain GST_N_4 PF17172.4 ADV24985.1 - 0.13 13.0 0.0 0.26 12.1 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase N-terminal domain MitoNEET_N PF10660.9 ADV24985.1 - 0.23 11.5 1.0 0.61 10.2 0.7 1.9 2 0 0 2 2 2 0 Iron-containing outer mitochondrial membrane protein N-terminus Forkhead PF00250.18 ADV24986.1 - 1.2e-23 83.1 0.0 2.4e-23 82.2 0.0 1.5 1 0 0 1 1 1 1 Forkhead domain tRNA_int_end_N2 PF12928.7 ADV24987.1 - 8.6e-15 54.7 0.0 1.7e-14 53.7 0.0 1.6 1 0 0 1 1 1 1 tRNA-splicing endonuclease subunit sen54 N-term tRNA_int_endo_N PF02778.14 ADV24987.1 - 0.00024 20.7 0.0 0.00044 19.9 0.0 1.4 1 0 0 1 1 1 1 tRNA intron endonuclease, N-terminal domain DNA_pol_B PF00136.21 ADV24988.1 - 6.8e-147 489.9 0.1 9.9e-147 489.3 0.1 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 ADV24988.1 - 1.3e-89 300.7 0.0 2.4e-89 299.8 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 ADV24988.1 - 3.9e-17 62.5 6.7 9.4e-17 61.2 6.7 1.7 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta DNA_pol_B_2 PF03175.13 ADV24988.1 - 0.01 14.8 0.3 0.029 13.2 0.0 1.8 2 0 0 2 2 2 1 DNA polymerase type B, organellar and viral DNA_pol_B_exo2 PF10108.9 ADV24988.1 - 0.065 12.9 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.6 ADV24988.1 - 0.14 12.1 0.1 0.68 9.9 0.1 2.2 1 1 0 1 1 1 0 RNase_H superfamily BMC PF00936.19 ADV24988.1 - 0.22 11.6 0.5 0.52 10.3 0.5 1.5 1 0 0 1 1 1 0 BMC domain Aconitase PF00330.20 ADV24989.1 - 3.3e-110 369.3 0.3 7.6e-109 364.8 0.3 2.2 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 ADV24989.1 - 6.9e-18 65.2 0.2 1.5e-17 64.2 0.2 1.7 1 1 0 1 1 1 1 Aconitase C-terminal domain DUF521 PF04412.13 ADV24989.1 - 0.018 13.8 0.0 0.03 13.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF521) EF-hand_4 PF12763.7 ADV24990.1 - 4.1e-23 81.3 0.0 1e-12 47.9 0.0 3.4 3 0 0 3 3 3 3 Cytoskeletal-regulatory complex EF hand UBA PF00627.31 ADV24990.1 - 1.6e-06 27.9 0.0 3.4e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 UBA/TS-N domain EF-hand_7 PF13499.6 ADV24990.1 - 2.6e-05 24.6 0.7 0.048 14.1 0.0 4.3 4 0 0 4 4 4 1 EF-hand domain pair EF-hand_1 PF00036.32 ADV24990.1 - 0.0017 17.8 8.3 0.87 9.3 0.0 4.8 5 0 0 5 5 5 2 EF hand EF-hand_8 PF13833.6 ADV24990.1 - 0.11 12.3 0.0 11 6.0 0.0 2.8 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_6 PF13405.6 ADV24990.1 - 0.67 10.0 7.6 16 5.7 0.0 4.6 5 0 0 5 5 5 0 EF-hand domain APG6_N PF17675.1 ADV24990.1 - 7.7 7.1 39.5 0.41 11.2 10.1 3.3 1 1 2 3 3 3 0 Apg6 coiled-coil region TPR_1 PF00515.28 ADV24991.1 - 6.4e-10 38.4 0.6 1.3e-06 27.9 0.2 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 ADV24991.1 - 6e-07 29.1 0.2 9.2e-05 22.3 0.1 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 ADV24991.1 - 7.7e-05 22.6 2.8 0.00016 21.6 0.1 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 ADV24991.1 - 0.033 13.9 0.0 9.4 6.0 0.0 2.4 2 0 0 2 2 2 0 TPR repeat TPR_7 PF13176.6 ADV24991.1 - 0.07 13.2 0.1 0.89 9.7 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TFCD_C PF12612.8 ADV24992.1 - 1.5e-25 90.2 0.0 4.5e-25 88.6 0.0 1.9 1 0 0 1 1 1 1 Tubulin folding cofactor D C terminal HEAT_EZ PF13513.6 ADV24992.1 - 0.0067 16.9 17.1 3.8 8.1 0.0 9.1 9 2 1 10 10 10 1 HEAT-like repeat HEAT_2 PF13646.6 ADV24992.1 - 0.046 14.1 9.9 7.4 7.0 0.0 6.4 6 2 0 6 6 6 0 HEAT repeats Cnd1 PF12717.7 ADV24992.1 - 0.1 12.6 0.4 16 5.5 0.0 3.2 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 HEAT_PBS PF03130.16 ADV24992.1 - 0.22 12.3 12.7 85 4.3 0.2 7.2 6 0 0 6 6 6 0 PBS lyase HEAT-like repeat HEAT PF02985.22 ADV24992.1 - 0.66 10.4 19.0 1.3 9.5 0.0 8.4 9 0 0 9 9 9 0 HEAT repeat ATG16 PF08614.11 ADV24993.1 - 1.4e-14 54.8 25.8 3.7e-13 50.2 18.2 4.7 3 2 1 4 4 4 2 Autophagy protein 16 (ATG16) TMF_DNA_bd PF12329.8 ADV24993.1 - 0.0012 18.8 3.0 0.0012 18.8 3.0 2.7 4 0 0 4 4 4 1 TATA element modulatory factor 1 DNA binding CENP-F_leu_zip PF10473.9 ADV24993.1 - 0.3 11.1 15.0 1.9 8.5 15.1 2.3 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AphA_like PF14557.6 ADV24993.1 - 0.63 9.7 4.6 1 9.0 4.6 1.2 1 0 0 1 1 1 0 Putative AphA-like transcriptional regulator DivIC PF04977.15 ADV24993.1 - 0.72 9.7 13.3 1.3 8.8 0.8 3.5 2 1 1 3 3 3 0 Septum formation initiator FlgN PF05130.12 ADV24993.1 - 1.2 9.6 14.3 0.84 10.1 8.6 2.3 2 0 0 2 2 2 0 FlgN protein DUF4407 PF14362.6 ADV24993.1 - 1.2 8.4 8.1 1.1 8.5 6.7 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) TMF_TATA_bd PF12325.8 ADV24993.1 - 1.3 9.3 16.8 3.5 7.9 5.1 3.3 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding SlyX PF04102.12 ADV24993.1 - 2.4 8.8 10.0 1.3 9.6 2.5 3.8 2 1 1 3 3 3 0 SlyX YabA PF06156.13 ADV24993.1 - 4 8.1 8.7 3.6 8.3 4.9 2.8 1 1 1 2 2 2 0 Initiation control protein YabA Cyt-b5 PF00173.28 ADV24994.1 - 5.4e-18 64.9 0.1 1.2e-17 63.8 0.1 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain FA_hydroxylase PF04116.13 ADV24994.1 - 3.7e-12 46.7 12.3 3.7e-12 46.7 12.3 2.2 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily DUF5016 PF16408.5 ADV24994.1 - 0.049 13.6 0.0 0.084 12.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5016) ARID PF01388.21 ADV24995.1 - 4.2e-16 59.4 0.0 3.3e-15 56.5 0.0 2.7 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain Lipase_GDSL_2 PF13472.6 ADV24996.1 - 4.3e-05 24.0 0.0 9.9e-05 22.8 0.0 1.7 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family UPF0020 PF01170.18 ADV24997.1 - 4.2e-08 33.1 0.0 1e-06 28.6 0.0 2.3 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 N6_N4_Mtase PF01555.18 ADV24997.1 - 0.0041 16.9 0.0 0.25 11.0 0.0 2.2 2 0 0 2 2 2 2 DNA methylase MethyltransfD12 PF02086.15 ADV24997.1 - 0.12 12.0 0.0 0.48 10.1 0.0 1.9 2 0 0 2 2 2 0 D12 class N6 adenine-specific DNA methyltransferase N6_Mtase PF02384.16 ADV24997.1 - 0.17 11.1 0.0 0.5 9.6 0.0 1.8 1 1 0 1 1 1 0 N-6 DNA Methylase PTPA PF03095.15 ADV24998.1 - 9.5e-76 255.1 0.0 1.2e-75 254.8 0.0 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein NAD_binding_11 PF14833.6 ADV25000.1 - 3.6e-52 175.8 0.3 3.8e-26 91.7 0.1 2.6 2 0 0 2 2 2 2 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase NAD_binding_2 PF03446.15 ADV25000.1 - 4.4e-46 156.9 6.4 1.6e-33 116.1 0.2 3.0 2 1 1 3 3 3 2 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.18 ADV25000.1 - 1e-05 25.5 1.5 2.9e-05 24.0 0.1 2.4 2 1 1 3 3 3 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain F420_oxidored PF03807.17 ADV25000.1 - 5.8e-05 23.6 3.4 0.014 15.9 0.0 3.5 2 1 0 3 3 3 1 NADP oxidoreductase coenzyme F420-dependent ApbA PF02558.16 ADV25000.1 - 0.0039 16.8 0.2 0.091 12.4 0.0 2.4 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA 2-Hacid_dh_C PF02826.19 ADV25000.1 - 0.006 16.0 0.0 0.012 15.0 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DRTGG PF07085.12 ADV25000.1 - 0.093 12.5 0.1 0.34 10.7 0.1 2.0 1 0 0 1 1 1 0 DRTGG domain UDPG_MGDP_dh PF00984.19 ADV25000.1 - 0.15 12.3 0.2 1.1 9.5 0.0 2.5 2 1 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, central domain Choline_transpo PF04515.12 ADV25002.1 - 2.7e-63 214.1 0.7 3.4e-63 213.8 0.7 1.1 1 0 0 1 1 1 1 Plasma-membrane choline transporter KCH PF16944.5 ADV25003.1 - 0.0028 17.5 0.0 0.0042 16.9 0.0 1.2 1 0 0 1 1 1 1 Fungal potassium channel PWI PF01480.17 ADV25005.1 - 6.2e-08 32.8 0.0 1.2e-07 31.9 0.0 1.5 1 0 0 1 1 1 1 PWI domain zf-CCCH PF00642.24 ADV25005.1 - 0.00012 21.9 5.7 0.00023 21.0 5.7 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 ADV25005.1 - 0.00023 21.1 5.5 0.00023 21.1 5.5 1.6 2 0 0 2 2 2 1 Zinc finger domain Nup35_RRM_2 PF14605.6 ADV25005.1 - 0.017 15.1 0.0 0.045 13.7 0.0 1.7 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Torus PF16131.5 ADV25005.1 - 0.029 15.1 0.1 0.077 13.7 0.1 1.7 1 0 0 1 1 1 0 Torus domain RRM_1 PF00076.22 ADV25005.1 - 0.076 12.9 0.0 1.1 9.1 0.0 2.4 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 ADV25005.1 - 0.076 13.1 0.0 0.28 11.2 0.0 2.0 1 0 0 1 1 1 0 RNA binding motif Glyco_hydro_18 PF00704.28 ADV25006.1 - 5.6e-42 144.6 8.7 8.7e-42 143.9 8.7 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 MFS_1 PF07690.16 ADV25007.1 - 5.5e-38 130.8 23.7 5.5e-38 130.8 23.7 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily 2OG-FeII_Oxy PF03171.20 ADV25008.1 - 1.7e-12 47.7 0.0 3.9e-12 46.6 0.0 1.6 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 ADV25008.1 - 5.6e-08 33.5 0.0 1.1e-07 32.7 0.0 1.4 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal Radical_SAM_C PF16199.5 ADV25010.1 - 9.6e-32 108.9 0.0 1.8e-31 108.0 0.0 1.5 1 0 0 1 1 1 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 ADV25010.1 - 2.7e-16 60.4 0.3 1.7e-15 57.8 0.1 2.2 2 0 0 2 2 2 1 Radical SAM superfamily Acetyltransf_1 PF00583.25 ADV25010.1 - 6.9e-11 42.4 0.2 1.5e-10 41.3 0.2 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ADV25010.1 - 2.5e-06 27.4 0.0 6.3e-06 26.1 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ADV25010.1 - 0.0054 17.1 0.1 0.012 16.0 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Synaptobrevin PF00957.21 ADV25011.1 - 1.7e-14 53.3 0.9 2.7e-14 52.7 0.9 1.3 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 ADV25011.1 - 1.8e-05 24.7 0.0 3.4e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 Regulated-SNARE-like domain DUF3500 PF12006.8 ADV25011.1 - 0.07 12.6 0.0 0.19 11.2 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3500) ERCC4 PF02732.15 ADV25012.1 - 2.5e-14 53.8 0.0 4.5e-14 52.9 0.0 1.4 1 0 0 1 1 1 1 ERCC4 domain DUF2250 PF10007.9 ADV25012.1 - 0.078 13.1 0.3 0.18 12.0 0.3 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2250) RabGAP-TBC PF00566.18 ADV25013.1 - 3.8e-54 183.6 1.8 6.2e-54 182.9 0.1 1.9 2 0 0 2 2 2 1 Rab-GTPase-TBC domain TAFH PF07531.14 ADV25013.1 - 0.034 14.3 0.6 0.075 13.1 0.6 1.5 1 0 0 1 1 1 0 NHR1 homology to TAF DUF4211 PF13926.6 ADV25014.1 - 3.2e-27 95.4 0.0 1e-26 93.7 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4211) Phage_lambda_P PF06992.11 ADV25014.1 - 0.055 13.2 0.1 0.24 11.1 0.1 2.1 2 0 0 2 2 2 0 Replication protein P tRNA-synt_1c PF00749.21 ADV25015.1 - 5.6e-87 291.6 0.0 7.5e-87 291.1 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain Aldose_epim PF01263.20 ADV25016.1 - 4.9e-40 137.7 0.0 5.4e-40 137.6 0.0 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase CS PF04969.16 ADV25017.1 - 0.0002 22.3 0.0 0.00036 21.5 0.0 1.4 1 0 0 1 1 1 1 CS domain Forkhead_N PF08430.12 ADV25017.1 - 0.0016 19.0 15.7 0.0024 18.5 15.7 1.2 1 0 0 1 1 1 1 Forkhead N-terminal region Sporozoite_P67 PF05642.11 ADV25017.1 - 8.7 4.3 11.4 10 4.0 11.4 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen ABC_tran PF00005.27 ADV25018.1 - 4.2e-26 92.1 0.0 6e-26 91.6 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ADV25018.1 - 5e-06 26.5 0.0 0.089 12.6 0.0 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ADV25018.1 - 1e-05 25.1 0.0 3.2e-05 23.5 0.0 1.7 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ADV25018.1 - 2.6e-05 23.9 0.0 7.7e-05 22.4 0.0 1.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_22 PF13401.6 ADV25018.1 - 0.00012 22.4 0.0 0.00036 20.8 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ADV25018.1 - 0.00019 21.9 0.0 0.00031 21.2 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain T2SSE PF00437.20 ADV25018.1 - 0.00021 20.4 0.0 0.00032 19.9 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein Rad17 PF03215.15 ADV25018.1 - 0.0014 18.5 0.0 0.0022 17.9 0.0 1.3 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_23 PF13476.6 ADV25018.1 - 0.0019 18.8 0.0 0.005 17.4 0.0 1.6 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 ADV25018.1 - 0.0043 17.0 0.1 0.0084 16.0 0.1 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_30 PF13604.6 ADV25018.1 - 0.0049 16.6 0.0 0.014 15.1 0.0 1.7 2 0 0 2 2 1 1 AAA domain SbcCD_C PF13558.6 ADV25018.1 - 0.0069 16.6 0.1 0.067 13.4 0.1 2.2 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_14 PF13173.6 ADV25018.1 - 0.0088 16.1 0.0 0.023 14.7 0.0 1.7 2 0 0 2 2 2 1 AAA domain ATPase_2 PF01637.18 ADV25018.1 - 0.0096 15.9 0.0 0.02 14.8 0.0 1.5 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_33 PF13671.6 ADV25018.1 - 0.01 16.0 0.1 0.036 14.2 0.0 2.0 2 1 0 2 2 2 0 AAA domain NACHT PF05729.12 ADV25018.1 - 0.019 14.9 0.0 0.038 13.9 0.0 1.5 1 0 0 1 1 1 0 NACHT domain Herpes_ori_bp PF02399.15 ADV25018.1 - 0.024 12.7 0.0 0.034 12.2 0.0 1.1 1 0 0 1 1 1 0 Origin of replication binding protein AAA_5 PF07728.14 ADV25018.1 - 0.037 14.0 0.1 0.4 10.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA PF00004.29 ADV25018.1 - 0.04 14.3 0.0 7.9 6.9 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Septin PF00735.18 ADV25018.1 - 0.046 13.0 0.0 0.078 12.2 0.0 1.3 1 0 0 1 1 1 0 Septin AAA_27 PF13514.6 ADV25018.1 - 0.064 12.8 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain Cytidylate_kin PF02224.18 ADV25018.1 - 0.081 12.6 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Cytidylate kinase NB-ARC PF00931.22 ADV25018.1 - 0.093 11.9 0.0 0.18 10.9 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain Mg_chelatase PF01078.21 ADV25018.1 - 0.12 11.8 0.0 0.38 10.1 0.0 1.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI cobW PF02492.19 ADV25018.1 - 0.12 11.9 0.0 0.2 11.2 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.6 ADV25018.1 - 0.13 12.8 0.0 0.25 11.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 ADV25018.1 - 0.15 11.8 0.0 0.24 11.1 0.0 1.4 1 1 0 1 1 1 0 AAA domain Glyco_transf_90 PF05686.12 ADV25019.1 - 1.9e-16 60.0 0.1 2.3e-15 56.4 0.1 2.5 2 1 0 2 2 2 1 Glycosyl transferase family 90 SET PF00856.28 ADV25020.1 - 7.9e-07 29.6 0.4 7.2e-06 26.5 0.4 2.4 1 1 0 1 1 1 1 SET domain preSET_CXC PF18264.1 ADV25020.1 - 3.4e-05 24.2 13.1 3.4e-05 24.2 13.1 3.7 2 1 1 3 3 3 1 CXC domain F-box-like PF12937.7 ADV25021.1 - 4e-07 29.8 1.0 8e-07 28.9 1.0 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ADV25021.1 - 0.0073 16.2 1.1 0.017 15.0 1.1 1.6 1 0 0 1 1 1 1 F-box domain DUF1908 PF08926.11 ADV25021.1 - 0.065 12.3 0.4 0.099 11.7 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1908) WD40 PF00400.32 ADV25022.1 - 9.5e-21 73.7 1.3 5.2e-07 30.3 0.0 5.8 6 0 0 6 6 6 3 WD domain, G-beta repeat Nup160 PF11715.8 ADV25022.1 - 0.023 13.4 0.2 0.28 9.8 0.0 2.5 2 1 1 3 3 3 0 Nucleoporin Nup120/160 His_Phos_1 PF00300.22 ADV25023.1 - 1.6e-20 73.6 0.0 2.4e-20 73.1 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Fungal_trans PF04082.18 ADV25024.1 - 1.4e-13 50.5 0.7 1.3e-11 44.0 0.0 3.0 2 2 1 3 3 3 2 Fungal specific transcription factor domain Gal4_dimer PF03902.13 ADV25024.1 - 0.012 15.8 0.6 0.034 14.3 0.0 2.0 2 0 0 2 2 2 0 Gal4-like dimerisation domain PAC2 PF09754.9 ADV25025.1 - 2.8e-15 56.9 0.0 3.5e-15 56.6 0.0 1.2 1 0 0 1 1 1 1 PAC2 family SBDS PF01172.18 ADV25027.1 - 4.7e-32 109.9 0.5 7.4e-32 109.3 0.5 1.3 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein SBDS_C PF09377.10 ADV25027.1 - 1.3e-31 109.0 0.1 2.6e-31 108.0 0.1 1.5 1 0 0 1 1 1 1 SBDS protein C-terminal domain Asn_synthase PF00733.21 ADV25029.1 - 1.8e-13 50.9 1.0 2.6e-05 24.1 0.0 3.2 2 1 1 3 3 3 3 Asparagine synthase GATase_7 PF13537.6 ADV25029.1 - 0.073 13.0 0.0 0.2 11.6 0.0 1.7 1 1 0 1 1 1 0 Glutamine amidotransferase domain WD40 PF00400.32 ADV25030.1 - 2.8e-07 31.1 0.0 0.41 11.6 0.0 4.8 4 0 0 4 4 4 3 WD domain, G-beta repeat Autophagy_N PF03986.13 ADV25031.1 - 5.2e-43 146.3 0.0 9e-43 145.5 0.0 1.5 1 0 0 1 1 1 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_act_C PF03987.15 ADV25031.1 - 2.6e-18 66.3 0.4 5.4e-18 65.3 0.4 1.6 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Autophagy_C PF10381.9 ADV25031.1 - 6.2e-13 48.0 3.0 1.3e-12 47.0 3.0 1.6 1 0 0 1 1 1 1 Autophagocytosis associated protein C-terminal Laminin_G_1 PF00054.23 ADV25032.1 - 0.11 12.7 0.2 0.32 11.2 0.1 1.7 1 1 0 1 1 1 0 Laminin G domain RPN7 PF10602.9 ADV25033.1 - 1.4e-54 184.4 1.4 2.6e-54 183.6 1.4 1.4 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 ADV25033.1 - 2.3e-15 57.0 0.6 7.5e-15 55.3 0.0 2.2 2 0 0 2 2 2 1 PCI domain DUF5045 PF16464.5 ADV25033.1 - 0.078 13.3 0.4 0.18 12.1 0.4 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF5045) iPGM_N PF06415.13 ADV25034.1 - 6.5e-78 261.1 0.2 1e-77 260.4 0.2 1.3 1 0 0 1 1 1 1 BPG-independent PGAM N-terminus (iPGM_N) Metalloenzyme PF01676.18 ADV25034.1 - 1.1e-76 257.5 1.0 1.4e-76 257.2 1.0 1.1 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.23 ADV25034.1 - 8e-09 35.3 0.1 4.5e-08 32.8 0.1 1.9 1 1 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 ADV25034.1 - 0.00098 18.8 0.0 0.0018 18.0 0.0 1.4 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Alk_phosphatase PF00245.20 ADV25034.1 - 0.002 17.1 0.3 0.0083 15.1 0.1 2.0 2 0 0 2 2 2 1 Alkaline phosphatase PglZ PF08665.12 ADV25034.1 - 0.0087 16.2 0.0 0.03 14.4 0.0 1.8 2 0 0 2 2 2 1 PglZ domain Glycos_transf_4 PF00953.21 ADV25035.1 - 1.3e-32 113.0 6.8 3e-32 111.8 6.8 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 4 PH PF00169.29 ADV25036.1 - 0.025 15.1 0.0 0.073 13.6 0.0 1.8 1 0 0 1 1 1 0 PH domain DCP2 PF05026.13 ADV25037.1 - 6.5e-22 77.7 0.2 1.7e-21 76.3 0.1 1.8 2 0 0 2 2 2 1 Dcp2, box A domain NUDIX PF00293.28 ADV25037.1 - 5.8e-16 58.7 0.1 1.2e-15 57.7 0.1 1.4 1 0 0 1 1 1 1 NUDIX domain Mitoc_mL59 PF18126.1 ADV25037.1 - 0.58 10.5 4.2 0.18 12.1 0.2 2.1 2 0 0 2 2 2 0 Mitochondrial ribosomal protein mL59 DLH PF01738.18 ADV25038.1 - 5.5e-30 104.5 0.0 6.9e-30 104.2 0.0 1.0 1 0 0 1 1 1 1 Dienelactone hydrolase family BAAT_C PF08840.11 ADV25038.1 - 0.00014 21.9 0.1 0.00046 20.2 0.0 1.8 1 1 1 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_1 PF00561.20 ADV25038.1 - 0.025 14.3 0.0 1.1 8.9 0.0 2.1 1 1 1 2 2 2 0 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ADV25038.1 - 0.091 12.0 0.0 2.1 7.6 0.0 2.7 2 1 1 3 3 3 0 Serine aminopeptidase, S33 PALP PF00291.25 ADV25040.1 - 9.9e-60 202.4 0.1 7.7e-50 170.0 0.0 2.0 2 0 0 2 2 2 2 Pyridoxal-phosphate dependent enzyme RBFA PF02033.18 ADV25041.1 - 0.098 13.1 0.0 0.18 12.3 0.0 1.4 1 0 0 1 1 1 0 Ribosome-binding factor A OrfB_IS605 PF01385.19 ADV25042.1 - 0.056 13.7 1.0 0.056 13.7 1.0 3.2 3 1 0 3 3 3 0 Probable transposase AhpC-TSA PF00578.21 ADV25043.1 - 1.6e-29 102.4 0.0 2.1e-29 101.9 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 ADV25043.1 - 2.2e-11 43.7 0.0 2.7e-11 43.4 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 ADV25043.1 - 5.6e-05 22.9 0.0 0.00011 22.0 0.0 1.5 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin UCH PF00443.29 ADV25044.1 - 4.6e-39 134.4 0.0 8e-39 133.7 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ADV25044.1 - 1.8e-06 27.8 0.0 0.00016 21.4 0.0 2.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Ribosomal_L19e PF01280.20 ADV25044.1 - 0.95 9.5 8.5 0.098 12.7 2.9 2.2 3 0 0 3 3 3 0 Ribosomal protein L19e Abhydrolase_1 PF00561.20 ADV25045.1 - 4.2e-10 39.7 0.1 4.8e-09 36.2 0.1 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ADV25045.1 - 1.4e-05 25.8 0.9 2.5e-05 25.0 0.9 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ADV25045.1 - 0.00023 20.5 0.5 0.00097 18.5 0.0 2.1 3 0 0 3 3 3 1 Serine aminopeptidase, S33 XFP_N PF09364.10 ADV25046.1 - 6.1e-174 578.0 0.0 9.1e-174 577.5 0.0 1.2 1 0 0 1 1 1 1 XFP N-terminal domain XFP_C PF09363.10 ADV25046.1 - 1e-82 276.5 0.0 1.6e-82 275.9 0.0 1.3 1 0 0 1 1 1 1 XFP C-terminal domain XFP PF03894.15 ADV25046.1 - 2.1e-81 271.8 0.0 3.2e-81 271.2 0.0 1.3 1 0 0 1 1 1 1 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase SBF PF01758.16 ADV25047.1 - 1.8e-42 145.2 10.0 1.8e-42 145.2 10.0 1.9 3 0 0 3 3 3 1 Sodium Bile acid symporter family Robl_LC7 PF03259.17 ADV25049.1 - 7.2e-07 28.9 0.0 0.00028 20.6 0.0 2.5 2 1 1 3 3 3 2 Roadblock/LC7 domain Sugar_tr PF00083.24 ADV25050.1 - 1.4e-79 268.1 17.5 1.7e-79 267.8 17.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ADV25050.1 - 1.7e-21 76.6 58.8 8.4e-17 61.1 31.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily PUCC PF03209.15 ADV25050.1 - 0.0026 16.8 0.1 0.0026 16.8 0.1 2.5 3 0 0 3 3 3 1 PUCC protein Brr6_like_C_C PF10104.9 ADV25050.1 - 0.22 11.3 0.5 0.59 9.9 0.5 1.7 1 0 0 1 1 1 0 Di-sulfide bridge nucleocytoplasmic transport domain Ferlin_C PF16165.5 ADV25050.1 - 0.28 11.1 0.7 0.53 10.2 0.7 1.4 1 0 0 1 1 1 0 Ferlin C-terminus Sugar_tr PF00083.24 ADV25052.1 - 1.2e-75 255.1 25.7 1.5e-75 254.8 25.7 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ADV25052.1 - 1.2e-11 44.2 36.4 1.2e-11 44.2 36.4 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 ADV25052.1 - 0.00033 19.7 5.0 0.00033 19.7 5.0 2.3 1 1 1 2 2 2 1 MFS_1 like family E1-E2_ATPase PF00122.20 ADV25053.1 - 3.2e-47 160.4 2.6 4.5e-47 159.9 0.7 2.3 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 ADV25053.1 - 4.4e-32 112.1 0.1 1.3e-30 107.2 0.1 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 ADV25053.1 - 2.3e-21 76.0 0.0 7.5e-10 39.1 0.1 4.0 3 0 0 3 3 3 3 Heavy-metal-associated domain Hydrolase_3 PF08282.12 ADV25053.1 - 5.1e-06 26.4 0.1 7.1e-05 22.7 0.0 2.3 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 ADV25053.1 - 0.037 14.1 0.0 0.13 12.3 0.0 1.9 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Toxin-deaminase PF14424.6 ADV25053.1 - 0.18 11.9 0.7 0.48 10.5 0.0 2.0 2 0 0 2 2 2 0 The BURPS668_1122 family of deaminases DiS_P_DiS PF06750.13 ADV25053.1 - 3.7 7.7 6.1 2.5 8.3 0.1 3.0 4 0 0 4 4 4 0 Bacterial Peptidase A24 N-terminal domain Sugar_tr PF00083.24 ADV25054.1 - 3.7e-75 253.5 21.5 4.6e-75 253.2 21.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ADV25054.1 - 2.9e-21 75.8 41.5 2.6e-17 62.8 14.6 2.2 1 1 0 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 ADV25054.1 - 0.00026 19.7 1.8 0.00026 19.7 1.8 2.8 3 1 0 3 3 3 1 MFS/sugar transport protein MFS_1_like PF12832.7 ADV25054.1 - 0.00096 18.1 5.1 0.00096 18.1 5.1 2.1 2 0 0 2 2 2 1 MFS_1 like family DUF2182 PF09948.9 ADV25054.1 - 0.021 14.7 6.1 0.13 12.1 0.4 3.1 2 1 1 3 3 3 0 Predicted metal-binding integral membrane protein (DUF2182) TMEM43 PF07787.12 ADV25054.1 - 0.092 12.1 0.1 0.25 10.7 0.1 1.7 1 0 0 1 1 1 0 Transmembrane protein 43 Glyco_hydro_3_C PF01915.22 ADV25055.1 - 1.2e-21 77.6 0.0 2e-21 76.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 ADV25055.1 - 2.8e-21 75.4 0.0 6.1e-21 74.3 0.0 1.6 1 0 0 1 1 1 1 Fibronectin type III-like domain PA14 PF07691.12 ADV25055.1 - 3.5e-10 39.8 0.0 6.1e-10 39.1 0.0 1.3 1 0 0 1 1 1 1 PA14 domain Fungal_trans PF04082.18 ADV25056.1 - 2.6e-06 26.7 0.1 7.2e-06 25.2 0.1 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain Mannosyl_trans4 PF15971.5 ADV25056.1 - 0.048 13.5 0.0 0.075 12.9 0.0 1.2 1 0 0 1 1 1 0 DolP-mannose mannosyltransferase DUF1107 PF06526.12 ADV25057.1 - 0.22 11.4 0.0 0.44 10.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1107) MFS_1 PF07690.16 ADV25058.1 - 6.2e-27 94.4 34.9 7.4e-27 94.2 34.9 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ADV25058.1 - 0.00048 19.1 12.7 0.00084 18.3 11.0 2.1 1 1 0 1 1 1 1 Sugar (and other) transporter Ac76 PF05814.11 ADV25058.1 - 0.004 17.1 0.3 0.011 15.7 0.3 1.8 1 0 0 1 1 1 1 Orf76 (Ac76) Rick_17kDa_Anti PF05433.15 ADV25058.1 - 0.082 12.8 1.8 7.7 6.5 0.5 2.5 2 0 0 2 2 2 0 Glycine zipper 2TM domain Gly-zipper_YMGG PF13441.6 ADV25058.1 - 0.17 11.7 2.8 0.63 9.8 2.5 2.1 1 1 0 1 1 1 0 YMGG-like Gly-zipper Gly-zipper_Omp PF13488.6 ADV25058.1 - 2.3 8.3 8.7 3.1 7.9 2.4 2.3 1 1 1 2 2 2 0 Glycine zipper AgrB PF04647.15 ADV25058.1 - 3.4 7.0 13.3 0.22 10.8 7.5 1.9 2 0 0 2 2 2 0 Accessory gene regulator B Isochorismatase PF00857.20 ADV25060.1 - 8.1e-43 146.6 0.0 9.2e-43 146.4 0.0 1.0 1 0 0 1 1 1 1 Isochorismatase family Sugar_tr PF00083.24 ADV25061.1 - 9.9e-74 248.8 12.6 1.2e-73 248.5 12.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ADV25061.1 - 5.7e-16 58.4 26.7 9.9e-10 37.9 17.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF4149 PF13664.6 ADV25061.1 - 0.02 15.2 1.9 0.02 15.2 1.9 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4149) Brr6_like_C_C PF10104.9 ADV25061.1 - 0.12 12.1 1.1 0.32 10.8 1.1 1.7 1 0 0 1 1 1 0 Di-sulfide bridge nucleocytoplasmic transport domain Fungal_trans PF04082.18 ADV25062.1 - 4.3e-06 26.0 0.1 8.1e-06 25.0 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ADV25062.1 - 1.6e-05 24.9 5.7 3.1e-05 24.0 5.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_hydro_3_C PF01915.22 ADV25063.1 - 3e-56 190.6 0.0 5.8e-56 189.7 0.0 1.5 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 ADV25063.1 - 1.5e-48 165.9 0.0 2.3e-48 165.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 ADV25063.1 - 1.1e-14 54.3 0.0 2.8e-14 53.0 0.0 1.8 1 0 0 1 1 1 1 Fibronectin type III-like domain PA14 PF07691.12 ADV25063.1 - 0.00017 21.4 0.0 0.00041 20.2 0.0 1.6 1 0 0 1 1 1 1 PA14 domain Aconitase_2_N PF06434.13 ADV25063.1 - 0.16 11.6 0.0 0.29 10.7 0.0 1.3 1 0 0 1 1 1 0 Aconitate hydratase 2 N-terminus RasGAP PF00616.19 ADV25064.1 - 4.1e-59 199.8 0.0 1.4e-58 198.0 0.0 1.9 2 0 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.15 ADV25064.1 - 1.5e-31 109.3 0.1 1.5e-31 109.3 0.1 2.4 3 0 0 3 3 3 1 RasGAP C-terminus DUF3984 PF13136.6 ADV25064.1 - 0.23 10.8 2.5 0.26 10.6 1.3 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3984) GABP-alpha PF11620.8 ADV25064.1 - 0.47 10.7 3.4 1.9 8.7 0.1 3.2 3 0 0 3 3 3 0 GA-binding protein alpha chain YabA PF06156.13 ADV25064.1 - 1.8 9.3 7.4 10 6.8 0.8 3.1 3 0 0 3 3 3 0 Initiation control protein YabA Pro_isomerase PF00160.21 ADV25065.1 - 4.1e-35 121.4 0.0 9.9e-35 120.2 0.0 1.7 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TMPIT PF07851.13 ADV25065.1 - 6.7 5.9 6.3 9.8 5.3 6.3 1.2 1 0 0 1 1 1 0 TMPIT-like protein MFS_1 PF07690.16 ADV25066.1 - 5.6e-27 94.6 24.6 3.3e-24 85.5 23.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Glyco_hydro_32N PF00251.20 ADV25067.1 - 1.5e-79 267.8 2.9 1.9e-79 267.4 2.9 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 N-terminal domain Glyco_hydro_32C PF08244.12 ADV25067.1 - 1.3e-09 38.3 0.1 2.2e-09 37.5 0.1 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 C terminal Homeodomain PF00046.29 ADV25068.1 - 9.7e-15 54.2 0.1 2.2e-14 53.0 0.1 1.6 1 0 0 1 1 1 1 Homeodomain Fibrillarin PF01269.17 ADV25069.1 - 4.1e-108 359.7 0.0 4.9e-108 359.5 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.10 ADV25069.1 - 2e-06 27.6 0.0 3.2e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit FtsJ PF01728.19 ADV25069.1 - 0.0026 17.9 0.0 0.0034 17.5 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltr_RsmB-F PF01189.17 ADV25069.1 - 0.012 15.2 0.0 0.09 12.4 0.0 2.2 2 1 0 3 3 3 0 16S rRNA methyltransferase RsmB/F PCMT PF01135.19 ADV25069.1 - 0.015 15.1 0.1 0.032 14.0 0.1 1.6 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MAGI_u1 PF16663.5 ADV25070.1 - 0.11 12.6 0.3 0.11 12.6 0.3 2.5 2 0 0 2 2 2 0 Unstructured region on MAGI FliJ PF02050.16 ADV25070.1 - 1.5 9.0 4.6 0.32 11.2 0.2 2.0 2 0 0 2 2 2 0 Flagellar FliJ protein Tubulin PF00091.25 ADV25071.1 - 2.2e-68 230.3 0.0 1.9e-67 227.3 0.0 2.0 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ADV25071.1 - 1.3e-40 138.4 0.1 2.5e-40 137.5 0.1 1.5 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 ADV25071.1 - 0.00021 21.6 0.0 0.00085 19.6 0.0 2.0 1 1 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 ADV25071.1 - 0.0012 18.6 0.0 0.0033 17.1 0.0 1.7 2 0 0 2 2 2 1 Tubulin domain Tubulin_2 PF13809.6 ADV25071.1 - 0.12 11.6 0.2 0.28 10.3 0.1 1.7 1 1 1 2 2 2 0 Tubulin like HAD_2 PF13419.6 ADV25071.1 - 0.14 12.2 0.0 0.43 10.6 0.0 1.8 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Hrs_helical PF12210.8 ADV25071.1 - 0.15 12.6 1.3 0.21 12.2 0.2 1.7 2 0 0 2 2 2 0 Hepatocyte growth factor-regulated tyrosine kinase substrate SOR_SNZ PF01680.17 ADV25072.1 - 7.8e-110 365.5 5.9 1.2e-109 364.9 5.9 1.3 1 0 0 1 1 1 1 SOR/SNZ family ThiG PF05690.14 ADV25072.1 - 3e-09 36.6 6.1 6.1e-07 29.0 0.1 2.3 2 0 0 2 2 2 2 Thiazole biosynthesis protein ThiG Dus PF01207.17 ADV25072.1 - 0.00012 21.3 0.7 0.17 11.0 0.0 2.5 2 1 0 2 2 2 2 Dihydrouridine synthase (Dus) TetR_C_27 PF17935.1 ADV25072.1 - 0.00095 19.2 0.0 0.0024 17.9 0.0 1.6 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain FMN_dh PF01070.18 ADV25072.1 - 0.015 14.3 2.1 0.055 12.5 0.0 2.4 3 0 0 3 3 3 0 FMN-dependent dehydrogenase NanE PF04131.14 ADV25072.1 - 0.022 14.0 1.0 0.51 9.5 0.0 2.6 2 2 0 2 2 2 0 Putative N-acetylmannosamine-6-phosphate epimerase His_biosynth PF00977.21 ADV25072.1 - 0.025 14.1 1.0 1.2 8.5 0.0 2.7 2 1 0 2 2 2 0 Histidine biosynthesis protein IGPS PF00218.21 ADV25072.1 - 0.048 12.8 0.3 2.3 7.3 0.0 2.6 2 1 0 2 2 2 0 Indole-3-glycerol phosphate synthase NMO PF03060.15 ADV25072.1 - 0.064 12.6 5.5 0.2 11.0 0.1 2.4 2 0 0 2 2 2 0 Nitronate monooxygenase RRM_1 PF00076.22 ADV25073.1 - 7.8e-11 41.6 0.0 1.5e-10 40.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HeLo PF14479.6 ADV25074.1 - 0.27 11.1 6.2 1.3 8.9 6.5 1.9 2 0 0 2 2 2 0 Prion-inhibition and propagation Chs7 PF12271.8 ADV25075.1 - 7.4e-111 370.1 20.9 8.6e-111 369.9 20.9 1.0 1 0 0 1 1 1 1 Chitin synthase export chaperone R3H PF01424.22 ADV25077.1 - 1.6e-07 31.2 0.1 3.5e-07 30.1 0.1 1.6 1 0 0 1 1 1 1 R3H domain RRM_1 PF00076.22 ADV25077.1 - 1.9e-06 27.6 0.1 5e-06 26.2 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Methyltransf_31 PF13847.6 ADV25079.1 - 1.4e-05 25.0 0.0 2.6e-05 24.1 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ADV25079.1 - 0.015 16.0 0.0 0.09 13.5 0.0 2.3 2 1 0 2 2 2 0 Methyltransferase domain Methyltransf_11 PF08241.12 ADV25079.1 - 0.024 15.3 0.0 0.11 13.1 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase domain MFS_1 PF07690.16 ADV25080.1 - 2.6e-29 102.2 26.3 3.5e-29 101.9 26.3 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Na_H_Exchanger PF00999.21 ADV25081.1 - 3.3e-24 85.4 32.2 1.3e-15 57.1 23.4 2.0 2 0 0 2 2 2 2 Sodium/hydrogen exchanger family Sdh_cyt PF01127.22 ADV25081.1 - 2.5 8.2 16.0 0.044 13.8 1.0 3.4 3 0 0 3 3 3 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit FtsJ PF01728.19 ADV25082.1 - 2.5e-68 229.7 0.0 3.7e-68 229.1 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase Pkinase PF00069.25 ADV25082.1 - 2.3e-39 135.4 0.0 1.3e-38 132.9 0.0 2.1 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV25082.1 - 1.4e-21 77.0 0.0 2.2e-21 76.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ADV25082.1 - 0.047 13.0 0.0 1.9 7.7 0.0 2.1 2 0 0 2 2 2 0 Kinase-like bZIP_1 PF00170.21 ADV25083.1 - 0.00012 22.1 17.6 0.013 15.5 8.1 3.6 3 0 0 3 3 3 2 bZIP transcription factor Use1 PF09753.9 ADV25083.1 - 0.00072 19.4 1.5 0.00072 19.4 1.5 2.5 4 0 0 4 4 3 1 Membrane fusion protein Use1 PI3K_P85_iSH2 PF16454.5 ADV25083.1 - 0.0016 18.1 5.5 1 8.9 0.8 3.3 3 0 0 3 3 3 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain WD40_alt PF14077.6 ADV25083.1 - 0.037 13.9 0.1 0.1 12.5 0.1 1.7 1 0 0 1 1 1 0 Alternative WD40 repeat motif HAP1_N PF04849.13 ADV25083.1 - 0.043 13.0 6.6 2.4 7.3 2.7 2.3 2 0 0 2 2 2 0 HAP1 N-terminal conserved region LOH1CR12 PF10158.9 ADV25083.1 - 0.06 13.4 2.9 0.066 13.2 1.3 1.8 2 0 0 2 2 1 0 Tumour suppressor protein TSC22 PF01166.18 ADV25083.1 - 0.069 13.5 9.3 0.82 10.0 2.6 2.8 2 0 0 2 2 2 0 TSC-22/dip/bun family TolA_bind_tri PF16331.5 ADV25083.1 - 0.095 12.8 8.0 1.2 9.2 0.1 3.5 4 0 0 4 4 3 0 TolA binding protein trimerisation Taxilin PF09728.9 ADV25083.1 - 0.26 10.4 14.9 0.13 11.4 3.4 2.5 3 0 0 3 3 3 0 Myosin-like coiled-coil protein HBM PF16591.5 ADV25083.1 - 0.39 10.1 16.7 1 8.8 1.3 3.3 3 0 0 3 3 3 0 Helical bimodular sensor domain EzrA PF06160.12 ADV25083.1 - 0.58 8.3 13.6 0.017 13.3 5.5 2.1 3 0 0 3 3 3 0 Septation ring formation regulator, EzrA Tho2 PF11262.8 ADV25083.1 - 0.87 8.7 8.3 0.048 12.9 1.2 2.1 2 0 0 2 2 2 0 Transcription factor/nuclear export subunit protein 2 FlaC_arch PF05377.11 ADV25083.1 - 1 9.8 7.7 0.43 11.0 3.3 2.3 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF3818 PF12825.7 ADV25083.1 - 1.1 8.2 5.8 12 4.8 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function in PX-proteins (DUF3818) Ax_dynein_light PF10211.9 ADV25083.1 - 1.2 9.1 15.5 0.21 11.5 7.0 2.5 2 0 0 2 2 2 0 Axonemal dynein light chain JIP_LZII PF16471.5 ADV25083.1 - 1.2 9.3 10.8 3.9 7.7 3.6 2.7 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II Cep57_MT_bd PF06657.13 ADV25083.1 - 1.7 9.2 8.7 0.4 11.2 1.7 2.6 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 DUF4795 PF16043.5 ADV25083.1 - 2 8.0 13.9 0.93 9.1 3.7 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4795) BRE1 PF08647.11 ADV25083.1 - 2.1 8.5 22.0 0.26 11.4 5.9 3.1 3 0 0 3 3 3 0 BRE1 E3 ubiquitin ligase HAUS-augmin3 PF14932.6 ADV25083.1 - 2.1 7.8 17.0 0.27 10.8 0.5 2.8 3 0 0 3 3 3 0 HAUS augmin-like complex subunit 3 DUF4618 PF15397.6 ADV25083.1 - 2.6 7.4 11.7 4.1 6.7 1.2 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4618) DUF16 PF01519.16 ADV25083.1 - 2.9 8.4 8.2 0.4 11.2 2.8 2.2 2 0 0 2 2 2 0 Protein of unknown function DUF16 DivIVA PF05103.13 ADV25083.1 - 3.3 7.8 20.5 0.21 11.7 9.8 2.8 3 0 0 3 3 3 0 DivIVA protein YabA PF06156.13 ADV25083.1 - 3.4 8.4 12.7 2.8 8.6 2.9 2.9 3 0 0 3 3 3 0 Initiation control protein YabA Atg14 PF10186.9 ADV25083.1 - 3.7 6.5 17.3 1.2 8.1 6.1 2.8 3 0 0 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 Rootletin PF15035.6 ADV25083.1 - 5.3 7.0 12.5 1.6 8.7 0.3 2.9 3 0 0 3 3 3 0 Ciliary rootlet component, centrosome cohesion Tektin PF03148.14 ADV25083.1 - 5.4 5.7 15.1 1.1 7.9 8.0 2.3 2 0 0 2 2 2 0 Tektin family GrpE PF01025.19 ADV25083.1 - 5.6 6.6 15.8 1.6 8.4 9.1 2.3 2 0 0 2 2 2 0 GrpE SHE3 PF17078.5 ADV25083.1 - 5.9 6.5 16.3 0.15 11.7 4.3 2.6 3 0 0 3 3 2 0 SWI5-dependent HO expression protein 3 TMF_DNA_bd PF12329.8 ADV25083.1 - 8.8 6.4 22.6 1.8 8.6 10.9 2.6 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding PRELI PF04707.14 ADV25085.1 - 2.6e-33 115.1 0.0 3e-33 114.9 0.0 1.0 1 0 0 1 1 1 1 PRELI-like family CBS PF00571.28 ADV25086.1 - 1.9e-06 28.2 0.0 0.045 14.2 0.0 2.1 2 0 0 2 2 2 2 CBS domain SMI1_KNR4 PF09346.10 ADV25089.1 - 1.6e-23 83.5 0.0 5.2e-23 81.9 0.0 1.8 2 0 0 2 2 2 1 SMI1 / KNR4 family (SUKH-1) Alpha-amylase PF00128.24 ADV25090.1 - 9.4e-51 173.3 0.0 2.9e-50 171.7 0.0 1.7 1 1 0 1 1 1 1 Alpha amylase, catalytic domain DUF1966 PF09260.11 ADV25090.1 - 8.7e-06 25.9 0.0 2.8e-05 24.3 0.0 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF1966) Fibrillin_U_N PF18193.1 ADV25090.1 - 0.025 14.7 1.2 0.39 10.9 0.0 2.5 2 0 0 2 2 2 0 Fibrillin 1 unique N-terminal domain OCD_Mu_crystall PF02423.15 ADV25091.1 - 1.1e-21 77.1 4.1 3.5e-16 59.0 0.7 2.2 1 1 1 2 2 2 2 Ornithine cyclodeaminase/mu-crystallin family Shikimate_DH PF01488.20 ADV25091.1 - 0.046 13.8 0.1 0.11 12.5 0.1 1.7 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase DUF364 PF04016.12 ADV25091.1 - 0.097 12.2 0.2 0.51 9.9 0.0 2.0 2 0 0 2 2 2 0 Putative heavy-metal chelation PHD PF00628.29 ADV25093.1 - 5.2e-08 32.7 7.4 8.6e-08 32.0 7.4 1.4 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 ADV25093.1 - 0.026 14.1 5.3 0.044 13.3 5.3 1.4 1 0 0 1 1 1 0 PHD-finger RFC1 PF08519.12 ADV25094.1 - 2.8e-58 196.5 0.1 3.8e-56 189.6 0.0 2.4 2 0 0 2 2 2 1 Replication factor RFC1 C terminal domain BRCT PF00533.26 ADV25094.1 - 5.5e-14 52.3 0.0 2.1e-13 50.5 0.0 2.1 2 0 0 2 2 1 1 BRCA1 C Terminus (BRCT) domain AAA PF00004.29 ADV25094.1 - 2.7e-10 40.8 0.0 8.6e-10 39.2 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 ADV25094.1 - 1.4e-06 28.4 0.0 3.5e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 Rad17 P-loop domain DNA_pol3_delta PF06144.13 ADV25094.1 - 0.00059 19.7 0.0 0.0018 18.1 0.0 1.8 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_22 PF13401.6 ADV25094.1 - 0.00099 19.4 0.0 0.026 14.8 0.0 3.0 2 1 0 2 2 2 1 AAA domain RuvB_N PF05496.12 ADV25094.1 - 0.0019 18.0 0.0 0.0045 16.8 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 ADV25094.1 - 0.003 18.0 0.0 0.011 16.2 0.0 2.0 1 0 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.6 ADV25094.1 - 0.0044 17.1 0.0 0.017 15.1 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 ADV25094.1 - 0.0068 16.4 0.1 0.28 11.2 0.0 2.6 1 1 1 2 2 2 1 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 ADV25094.1 - 0.0083 15.9 1.0 0.012 15.4 0.0 1.7 2 0 0 2 2 1 1 AAA domain AAA_33 PF13671.6 ADV25094.1 - 0.014 15.6 0.0 0.041 14.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 ADV25094.1 - 0.015 15.0 0.2 0.051 13.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 ADV25094.1 - 0.032 14.2 0.0 3.1 7.7 0.0 2.6 3 0 0 3 3 3 0 NACHT domain AAA_28 PF13521.6 ADV25094.1 - 0.056 13.7 0.2 0.38 11.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 ADV25094.1 - 0.25 11.9 0.0 0.25 11.9 0.0 2.5 3 0 0 3 3 2 0 AAA domain DUF1682 PF07946.14 ADV25094.1 - 1.2 8.3 12.5 3.5 6.7 12.5 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) AAA_11 PF13086.6 ADV25094.1 - 6.4 6.5 9.2 2.7 7.7 0.0 2.8 3 0 0 3 3 3 0 AAA domain ORC2 PF04084.14 ADV25095.1 - 6.3e-80 268.6 0.0 8.1e-80 268.2 0.0 1.1 1 0 0 1 1 1 1 Origin recognition complex subunit 2 YL1 PF05764.13 ADV25095.1 - 0.027 14.6 1.8 0.043 13.9 1.8 1.3 1 0 0 1 1 1 0 YL1 nuclear protein Acyl-CoA_dh_1 PF00441.24 ADV25097.1 - 1.5e-48 164.8 3.1 2.4e-48 164.1 3.1 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_2 PF08028.11 ADV25097.1 - 5.3e-19 68.8 1.9 7.8e-19 68.3 1.9 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 ADV25097.1 - 2e-10 40.7 0.1 4.4e-10 39.6 0.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain HpaB_N PF11794.8 ADV25097.1 - 0.0037 17.0 0.3 0.012 15.3 0.3 1.8 1 1 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase N terminal MFS_1 PF07690.16 ADV25098.1 - 7.4e-41 140.2 44.8 2.2e-40 138.7 39.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ADV25098.1 - 4.1e-07 29.2 33.9 1.2e-06 27.7 33.9 1.9 1 1 0 1 1 1 1 Sugar (and other) transporter PAP2 PF01569.21 ADV25098.1 - 0.0033 17.2 2.4 0.0033 17.2 2.4 2.8 2 1 0 2 2 2 1 PAP2 superfamily UNC-93 PF05978.16 ADV25098.1 - 0.0038 17.0 1.5 0.0038 17.0 1.5 3.2 3 1 0 3 3 3 1 Ion channel regulatory protein UNC-93 DUF4083 PF13314.6 ADV25098.1 - 1 9.4 0.0 1 9.4 0.0 3.3 4 0 0 4 4 4 0 Domain of unknown function (DUF4083) adh_short_C2 PF13561.6 ADV25099.1 - 2e-49 168.3 0.0 2.6e-49 167.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ADV25099.1 - 4.2e-38 130.8 0.1 5.7e-38 130.3 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ADV25099.1 - 8.5e-13 48.6 0.0 1.3e-12 48.0 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ADV25099.1 - 0.023 14.1 0.1 0.061 12.8 0.1 1.7 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Transketolase_N PF00456.21 ADV25100.1 - 3.8e-126 420.6 0.0 6e-126 419.9 0.0 1.3 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 ADV25100.1 - 3.3e-38 131.1 0.0 6.7e-38 130.1 0.0 1.5 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 ADV25100.1 - 9.2e-11 41.7 0.1 3.4e-10 39.9 0.1 1.9 1 1 0 1 1 1 1 Transketolase, C-terminal domain TPP_enzyme_C PF02775.21 ADV25100.1 - 1.5e-05 24.9 0.5 4.1e-05 23.4 0.1 1.9 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DXP_synthase_N PF13292.6 ADV25100.1 - 0.00011 21.5 0.1 0.00042 19.6 0.1 1.9 1 1 1 2 2 2 1 1-deoxy-D-xylulose-5-phosphate synthase DUF1985 PF09331.11 ADV25100.1 - 0.096 12.7 0.0 0.86 9.6 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1985) Glyco_hydro_3_C PF01915.22 ADV25102.1 - 3e-61 206.9 0.0 5.9e-61 206.0 0.0 1.5 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 ADV25102.1 - 2.5e-36 125.7 0.0 4e-36 125.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 ADV25102.1 - 1.1e-21 76.6 0.0 2.6e-21 75.5 0.0 1.7 1 0 0 1 1 1 1 Fibronectin type III-like domain PA14 PF07691.12 ADV25102.1 - 2.9e-10 40.1 0.0 5.8e-10 39.2 0.0 1.4 1 0 0 1 1 1 1 PA14 domain Lipase_GDSL_2 PF13472.6 ADV25102.1 - 0.033 14.6 0.0 0.081 13.3 0.0 1.6 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family DDE_Tnp_ISL3 PF01610.17 ADV25103.1 - 0.13 11.9 0.0 0.23 11.2 0.0 1.3 1 0 0 1 1 1 0 Transposase DPBB_1 PF03330.18 ADV25104.1 - 0.00019 21.6 0.0 0.00047 20.4 0.0 1.8 1 0 0 1 1 1 1 Lytic transglycolase PAXNEB PF05625.11 ADV25105.1 - 1.9e-32 112.8 0.0 8.3e-32 110.7 0.0 1.8 1 1 0 1 1 1 1 PAXNEB protein AAA PF00004.29 ADV25106.1 - 6.4e-13 49.3 0.0 2.3e-12 47.5 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 ADV25106.1 - 8e-06 25.9 0.1 0.0025 17.8 0.0 2.3 2 0 0 2 2 2 2 Rad17 P-loop domain AAA_5 PF07728.14 ADV25106.1 - 3.6e-05 23.8 0.0 8e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ADV25106.1 - 7.6e-05 23.2 0.0 0.00051 20.5 0.0 2.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.6 ADV25106.1 - 0.00039 20.5 0.0 0.00087 19.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 ADV25106.1 - 0.00045 20.0 0.0 0.0011 18.7 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 ADV25106.1 - 0.0013 19.0 0.0 0.004 17.4 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_assoc_2 PF16193.5 ADV25106.1 - 0.0066 16.8 0.0 0.015 15.7 0.0 1.6 1 0 0 1 1 1 1 AAA C-terminal domain DNA_pol3_delta PF06144.13 ADV25106.1 - 0.0095 15.7 0.0 0.022 14.6 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_33 PF13671.6 ADV25106.1 - 0.01 16.0 0.0 0.025 14.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 ADV25106.1 - 0.02 14.4 0.0 0.04 13.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_25 PF13481.6 ADV25106.1 - 0.022 14.3 0.0 0.051 13.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain GREB1 PF15782.5 ADV25106.1 - 0.1 9.7 0.0 0.14 9.3 0.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer AAA_18 PF13238.6 ADV25106.1 - 0.17 12.4 0.0 0.52 10.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain HLH PF00010.26 ADV25107.1 - 4e-12 45.9 0.7 7.9e-12 45.0 0.7 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF2423 PF10338.9 ADV25107.1 - 9.7 6.5 10.1 8.6 6.7 4.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2423) AP_endonuc_2 PF01261.24 ADV25108.1 - 1.7e-23 83.1 0.0 4.6e-23 81.8 0.0 1.7 1 1 0 1 1 1 1 Xylose isomerase-like TIM barrel SGL PF08450.12 ADV25109.1 - 6.3e-72 242.1 0.0 5.5e-71 239.0 0.0 1.9 2 0 0 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region Fungal_trans PF04082.18 ADV25110.1 - 3.8e-11 42.5 0.4 2.8e-09 36.4 0.1 2.6 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 ADV25110.1 - 3e-05 24.0 13.5 5.5e-05 23.2 13.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Herpes_BBRF1 PF04793.12 ADV25110.1 - 0.1 11.6 0.0 0.18 10.8 0.0 1.3 1 0 0 1 1 1 0 BRRF1-like protein Sugar_tr PF00083.24 ADV25111.1 - 2.8e-97 326.4 30.6 3.3e-97 326.2 30.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ADV25111.1 - 3.2e-22 78.9 39.0 2.9e-18 65.9 17.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 ADV25111.1 - 0.00033 19.2 3.6 0.00056 18.5 3.6 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Pox_P21 PF05313.12 ADV25111.1 - 0.076 12.6 3.5 0.23 11.0 3.2 1.8 1 1 0 1 1 1 0 Poxvirus P21 membrane protein DUF697 PF05128.12 ADV25111.1 - 0.16 11.7 3.1 0.3 10.8 0.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF697) COG6 PF06419.11 ADV25112.1 - 2.2e-165 551.4 0.0 2.7e-165 551.1 0.0 1.0 1 0 0 1 1 1 1 Conserved oligomeric complex COG6 DUF1633 PF07794.11 ADV25112.1 - 0.0018 16.6 0.0 0.0031 15.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1633) Pyridoxal_deC PF00282.19 ADV25113.1 - 2.8e-18 65.8 0.0 4.9e-18 65.0 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 ADV25113.1 - 3.4e-10 39.4 0.0 2.5e-09 36.6 0.0 2.0 1 1 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 ADV25113.1 - 0.026 13.9 0.0 0.041 13.2 0.0 1.2 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family MgsA_C PF12002.8 ADV25114.1 - 2.7e-55 186.8 0.1 5.9e-55 185.7 0.1 1.5 1 0 0 1 1 1 1 MgsA AAA+ ATPase C terminal AAA PF00004.29 ADV25114.1 - 1e-16 61.6 0.0 3e-16 60.1 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_assoc_2 PF16193.5 ADV25114.1 - 1.7e-14 53.9 2.5 4.2e-13 49.4 2.5 2.4 1 1 0 1 1 1 1 AAA C-terminal domain RuvB_N PF05496.12 ADV25114.1 - 1.7e-13 50.6 0.0 3.5e-13 49.6 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 ADV25114.1 - 1.8e-07 31.7 1.4 0.002 18.6 0.1 2.8 2 1 1 3 3 3 2 AAA ATPase domain AAA_5 PF07728.14 ADV25114.1 - 1.1e-05 25.5 0.0 5e-05 23.3 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ADV25114.1 - 1.7e-05 25.2 3.7 0.024 14.9 0.1 3.0 2 1 1 3 3 3 2 AAA domain Sigma54_activat PF00158.26 ADV25114.1 - 4.1e-05 23.3 0.0 0.0064 16.2 0.0 2.3 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_18 PF13238.6 ADV25114.1 - 5e-05 23.8 0.9 0.0011 19.5 0.0 2.9 3 0 0 3 3 3 1 AAA domain AAA_14 PF13173.6 ADV25114.1 - 5.4e-05 23.2 0.0 0.00012 22.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain Sigma54_activ_2 PF14532.6 ADV25114.1 - 0.00013 22.1 0.0 0.00027 21.1 0.0 1.5 1 0 0 1 1 1 1 Sigma-54 interaction domain Mg_chelatase PF01078.21 ADV25114.1 - 0.0011 18.4 0.1 0.3 10.4 0.0 2.3 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI Viral_helicase1 PF01443.18 ADV25114.1 - 0.0058 16.4 0.0 0.011 15.5 0.0 1.5 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_3 PF07726.11 ADV25114.1 - 0.0065 16.3 0.0 0.012 15.5 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 ADV25114.1 - 0.0075 16.6 0.0 0.017 15.5 0.0 1.6 1 0 0 1 1 1 1 RNA helicase ATPase_2 PF01637.18 ADV25114.1 - 0.0078 16.1 1.9 3 7.7 0.0 2.8 2 1 1 3 3 3 2 ATPase domain predominantly from Archaea ABC_tran PF00005.27 ADV25114.1 - 0.0081 16.7 0.7 0.021 15.3 0.0 2.0 2 0 0 2 2 1 1 ABC transporter Rad17 PF03215.15 ADV25114.1 - 0.0082 16.1 0.0 0.015 15.2 0.0 1.5 1 0 0 1 1 1 1 Rad17 P-loop domain TIP49 PF06068.13 ADV25114.1 - 0.017 14.4 0.0 0.029 13.6 0.0 1.4 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_33 PF13671.6 ADV25114.1 - 0.021 15.0 0.0 0.059 13.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain zf-WRNIP1_ubi PF18279.1 ADV25114.1 - 0.026 15.2 0.4 0.11 13.2 0.0 2.3 2 0 0 2 2 1 0 Werner helicase-interacting protein 1 ubiquitin-binding domain AAA_2 PF07724.14 ADV25114.1 - 0.028 14.5 0.1 0.1 12.7 0.0 1.9 2 0 0 2 2 2 0 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.17 ADV25114.1 - 0.054 13.2 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein NACHT PF05729.12 ADV25114.1 - 0.082 12.8 0.0 0.23 11.4 0.0 1.7 1 0 0 1 1 1 0 NACHT domain TsaE PF02367.17 ADV25114.1 - 0.084 12.9 0.0 0.16 12.0 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_25 PF13481.6 ADV25114.1 - 0.1 12.2 0.2 0.27 10.8 0.1 1.7 2 0 0 2 2 1 0 AAA domain AAA_24 PF13479.6 ADV25114.1 - 0.12 12.1 1.0 0.3 10.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain SKI PF01202.22 ADV25114.1 - 0.12 12.5 0.1 0.12 12.5 0.1 1.7 2 0 0 2 2 1 0 Shikimate kinase AAA_17 PF13207.6 ADV25114.1 - 0.12 12.8 3.5 0.39 11.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 ADV25114.1 - 0.13 12.5 0.0 0.13 12.5 0.0 2.6 3 0 0 3 3 2 0 AAA domain NB-ARC PF00931.22 ADV25114.1 - 0.16 11.1 0.7 0.73 9.0 0.0 2.2 2 1 1 3 3 3 0 NB-ARC domain AAA_19 PF13245.6 ADV25114.1 - 0.16 12.3 0.4 8.7 6.7 0.1 2.5 1 1 1 2 2 2 0 AAA domain ResIII PF04851.15 ADV25114.1 - 0.2 11.7 1.0 6.4 6.7 0.0 2.9 2 1 1 3 3 3 0 Type III restriction enzyme, res subunit AAA_11 PF13086.6 ADV25114.1 - 2 8.2 5.0 16 5.2 5.0 2.1 1 1 0 1 1 1 0 AAA domain Cation_efflux PF01545.21 ADV25115.1 - 1.8e-42 145.4 28.0 1.8e-42 145.4 28.0 2.1 2 2 0 2 2 2 1 Cation efflux family Macro PF01661.21 ADV25116.1 - 4.7e-35 120.2 0.1 6.9e-35 119.6 0.1 1.2 1 0 0 1 1 1 1 Macro domain Aminotran_5 PF00266.19 ADV25117.1 - 1.5e-35 122.8 0.0 3.1e-23 82.3 0.0 2.1 2 0 0 2 2 2 2 Aminotransferase class-V Peptidase_A22B PF04258.13 ADV25118.1 - 2.1e-73 247.3 10.5 2.6e-73 247.0 10.5 1.0 1 0 0 1 1 1 1 Signal peptide peptidase DUF2157 PF09925.9 ADV25118.1 - 0.088 12.6 0.1 0.088 12.6 0.1 2.7 3 0 0 3 3 3 0 Predicted membrane protein (DUF2157) Phenol_monoox PF04663.12 ADV25118.1 - 0.24 11.5 0.7 5.3 7.3 0.1 2.7 2 0 0 2 2 2 0 Phenol hydroxylase conserved region CMS1 PF14617.6 ADV25119.1 - 4e-43 147.6 0.6 6.1e-43 147.0 0.6 1.2 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit DEAD PF00270.29 ADV25119.1 - 0.01 15.6 0.0 0.017 14.9 0.0 1.3 1 0 0 1 1 1 0 DEAD/DEAH box helicase Peptidase_S49_N PF08496.10 ADV25119.1 - 0.036 14.1 4.6 0.065 13.3 4.6 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Rrn6 PF10214.9 ADV25119.1 - 0.074 11.5 2.2 0.096 11.2 2.2 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor CDC45 PF02724.14 ADV25119.1 - 0.73 8.1 11.3 1 7.6 11.3 1.1 1 0 0 1 1 1 0 CDC45-like protein RNA_polI_A34 PF08208.11 ADV25119.1 - 0.83 9.7 15.3 1.4 8.9 15.3 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 NARP1 PF12569.8 ADV25119.1 - 1.9 7.3 8.7 2.7 6.8 8.7 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 RR_TM4-6 PF06459.12 ADV25119.1 - 1.9 8.3 9.6 2.9 7.7 9.6 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TMEM214 PF10151.9 ADV25119.1 - 2 6.8 3.1 2.8 6.3 3.1 1.1 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator SET PF00856.28 ADV25120.1 - 2.4e-17 63.8 0.9 7.2e-16 59.0 0.0 3.0 2 0 0 2 2 2 1 SET domain Pre-SET PF05033.16 ADV25120.1 - 5.9e-15 55.9 0.4 1.4e-14 54.7 0.4 1.6 1 0 0 1 1 1 1 Pre-SET motif RabGAP-TBC PF00566.18 ADV25121.1 - 1.6e-38 132.6 0.2 2.3e-38 132.0 0.2 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain AAA_lid_11 PF18198.1 ADV25121.1 - 0.018 14.8 0.0 0.028 14.2 0.0 1.3 1 0 0 1 1 1 0 Dynein heavy chain AAA lid domain DUF1115 PF06544.12 ADV25122.1 - 1.5e-12 47.8 0.0 2.6e-12 47.1 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1115) CCDC106 PF15794.5 ADV25123.1 - 0.09 12.5 5.0 0.21 11.3 5.0 1.6 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 SOG2 PF10428.9 ADV25124.1 - 0.18 11.0 24.6 0.2 10.8 24.6 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Macoilin PF09726.9 ADV25124.1 - 0.4 9.2 13.7 0.46 9.0 13.7 1.1 1 0 0 1 1 1 0 Macoilin family RIFIN PF02009.16 ADV25124.1 - 3.1 7.6 4.3 3.6 7.4 4.3 1.2 1 0 0 1 1 1 0 Rifin SPX PF03105.19 ADV25124.1 - 4.2 7.2 13.7 5.2 6.9 13.7 1.1 1 0 0 1 1 1 0 SPX domain Plasmodium_Vir PF05795.11 ADV25124.1 - 8.7 5.7 5.3 9.4 5.5 5.3 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein G-gamma PF00631.22 ADV25125.1 - 2.7e-18 65.7 0.0 7.1e-18 64.4 0.0 1.7 1 0 0 1 1 1 1 GGL domain WD40 PF00400.32 ADV25126.1 - 1.6e-45 152.1 14.0 8.4e-10 39.1 0.1 6.7 6 0 0 6 6 6 6 WD domain, G-beta repeat TFIID_NTD2 PF04494.15 ADV25126.1 - 3.4e-29 101.7 0.2 7.8e-29 100.5 0.0 1.5 2 0 0 2 2 2 1 WD40 associated region in TFIID subunit, NTD2 domain ANAPC4_WD40 PF12894.7 ADV25126.1 - 1.7e-11 44.3 0.2 0.088 13.1 0.0 5.3 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ADV25126.1 - 0.018 14.0 0.1 14 4.5 0.0 3.5 2 1 2 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ADV25126.1 - 0.026 13.2 0.1 15 4.1 0.0 3.5 3 1 0 4 4 4 0 Nucleoporin Nup120/160 Nbas_N PF15492.6 ADV25126.1 - 0.065 12.5 0.1 1.5 8.1 0.0 2.4 2 0 0 2 2 2 0 Neuroblastoma-amplified sequence, N terminal HAT_KAT11 PF08214.11 ADV25127.1 - 1.6e-35 123.0 0.0 6.1e-35 121.1 0.0 1.7 1 1 0 1 1 1 1 Histone acetylation protein NAM-associated PF14303.6 ADV25127.1 - 4 8.1 8.1 8.4 7.1 8.1 1.4 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain Asn_synthase PF00733.21 ADV25128.1 - 3.3e-96 323.0 0.2 8e-57 193.5 0.0 2.1 1 1 1 2 2 2 2 Asparagine synthase GATase_7 PF13537.6 ADV25128.1 - 1.3e-37 128.4 0.0 2.3e-37 127.6 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 ADV25128.1 - 4.6e-31 107.8 0.0 9.6e-31 106.7 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.8 ADV25128.1 - 4.5e-05 23.0 0.0 0.0001 21.9 0.0 1.5 1 0 0 1 1 1 1 Aluminium induced protein NAD_synthase PF02540.17 ADV25128.1 - 0.073 12.2 0.0 0.13 11.4 0.0 1.3 1 0 0 1 1 1 0 NAD synthase SET PF00856.28 ADV25129.1 - 3.3e-13 50.4 0.0 8e-13 49.1 0.0 1.8 1 1 0 1 1 1 1 SET domain QueH PF02677.14 ADV25129.1 - 0.015 15.4 0.0 0.024 14.7 0.0 1.4 1 0 0 1 1 1 0 Epoxyqueuosine reductase QueH BRCT_2 PF16589.5 ADV25130.1 - 0.012 16.0 0.0 0.58 10.6 0.0 2.5 2 0 0 2 2 2 0 BRCT domain, a BRCA1 C-terminus domain zf-C2H2 PF00096.26 ADV25132.1 - 1.7e-09 37.6 8.4 2e-05 24.8 1.8 2.4 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ADV25132.1 - 4.3e-05 24.0 7.5 0.036 14.9 0.7 2.4 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ADV25132.1 - 0.0007 19.9 3.6 0.0007 19.9 3.6 3.0 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_6 PF13912.6 ADV25132.1 - 0.12 12.4 2.1 0.13 12.2 0.3 2.0 2 0 0 2 2 2 0 C2H2-type zinc finger zf-H2C2_5 PF13909.6 ADV25132.1 - 1.8 8.4 5.3 4.5 7.1 1.4 2.3 2 0 0 2 2 2 0 C2H2-type zinc-finger domain SUIM_assoc PF16619.5 ADV25132.1 - 6.8 6.8 20.3 5.3 7.2 16.4 2.9 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 RhoGEF PF00621.20 ADV25133.1 - 3e-17 63.4 0.0 2.2e-12 47.6 0.0 2.2 2 0 0 2 2 2 2 RhoGEF domain SKIP_SNW PF02731.15 ADV25135.1 - 3.1e-70 235.0 2.3 3.1e-70 235.0 2.3 2.2 2 0 0 2 2 2 1 SKIP/SNW domain Cwf_Cwc_15 PF04889.12 ADV25135.1 - 0.045 13.5 7.2 0.11 12.1 7.2 1.6 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Pep1_7 PF17232.2 ADV25135.1 - 0.45 11.0 3.3 1.4 9.5 3.3 1.7 1 0 0 1 1 1 0 Elicitor peptide 1-7 Gpi1 PF05024.15 ADV25137.1 - 1.3e-52 178.7 9.9 3.4e-52 177.3 9.9 1.7 1 1 0 1 1 1 1 N-acetylglucosaminyl transferase component (Gpi1) Glyco_hydro_9 PF00759.19 ADV25139.1 - 2e-102 343.7 17.5 2.4e-102 343.5 17.5 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 9 Adeno_E3_CR2 PF02439.15 ADV25139.1 - 0.0014 18.3 0.1 0.0027 17.4 0.1 1.3 1 0 0 1 1 1 1 Adenovirus E3 region protein CR2 VSP PF03302.13 ADV25139.1 - 0.14 11.0 8.8 0.2 10.5 8.8 1.1 1 0 0 1 1 1 0 Giardia variant-specific surface protein SKG6 PF08693.10 ADV25139.1 - 5.1 6.6 11.7 11 5.5 11.7 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Vac_ImportDeg PF09783.9 ADV25140.1 - 7.3e-46 155.9 0.0 1.1e-42 145.7 0.0 2.2 2 0 0 2 2 2 2 Vacuolar import and degradation protein DUF5427 PF10310.9 ADV25140.1 - 0.5 9.3 4.5 1.1 8.2 4.3 1.5 1 1 0 1 1 1 0 Family of unknown function (DUF5427) GATase PF00117.28 ADV25140.1 - 0.62 9.8 3.3 0.2 11.4 0.3 1.6 2 0 0 2 2 2 0 Glutamine amidotransferase class-I Keratin_2_head PF16208.5 ADV25140.1 - 1.2 9.3 16.6 0.051 13.7 10.6 1.7 2 0 0 2 2 2 0 Keratin type II head AAA PF00004.29 ADV25141.1 - 8.4e-16 58.6 0.0 1.8e-15 57.6 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 ADV25141.1 - 1.5e-11 44.4 0.0 2.8e-07 30.4 0.0 2.2 2 0 0 2 2 2 2 DNA polymerase III, delta subunit Rep_fac_C PF08542.11 ADV25141.1 - 2.4e-09 37.5 0.0 4.8e-09 36.5 0.0 1.5 1 0 0 1 1 1 1 Replication factor C C-terminal domain Rad17 PF03215.15 ADV25141.1 - 1.9e-07 31.2 0.0 6.1e-07 29.5 0.0 1.8 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_22 PF13401.6 ADV25141.1 - 3.9e-06 27.2 0.0 2.9e-05 24.4 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ADV25141.1 - 1e-05 26.0 0.0 0.00024 21.5 0.0 2.5 1 1 1 2 2 2 1 AAA ATPase domain AAA_11 PF13086.6 ADV25141.1 - 2.3e-05 24.3 0.0 4.5e-05 23.4 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 ADV25141.1 - 0.00017 21.4 0.0 0.0006 19.6 0.0 1.8 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 ADV25141.1 - 0.00045 19.7 0.0 0.0042 16.5 0.0 2.1 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI RuvB_N PF05496.12 ADV25141.1 - 0.00047 19.9 0.0 0.001 18.8 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_assoc_2 PF16193.5 ADV25141.1 - 0.00059 20.1 0.0 0.0013 19.0 0.0 1.6 1 0 0 1 1 1 1 AAA C-terminal domain AAA_19 PF13245.6 ADV25141.1 - 0.0015 18.9 0.0 0.0099 16.2 0.0 2.2 2 1 0 2 2 2 1 AAA domain AAA_24 PF13479.6 ADV25141.1 - 0.0019 18.0 0.0 0.0031 17.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 ADV25141.1 - 0.0019 18.2 0.0 0.12 12.3 0.0 2.2 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit AAA_5 PF07728.14 ADV25141.1 - 0.0071 16.4 0.0 0.019 15.0 0.0 1.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) DNA_pol3_delta PF06144.13 ADV25141.1 - 0.012 15.4 0.0 0.019 14.8 0.0 1.2 1 0 0 1 1 1 0 DNA polymerase III, delta subunit AAA_7 PF12775.7 ADV25141.1 - 0.014 14.9 0.0 0.025 14.1 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region DEAD PF00270.29 ADV25141.1 - 0.015 15.1 0.0 0.11 12.2 0.0 2.0 1 1 1 2 2 2 0 DEAD/DEAH box helicase DUF2075 PF09848.9 ADV25141.1 - 0.017 14.4 0.0 0.029 13.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) DUF815 PF05673.13 ADV25141.1 - 0.029 13.5 0.0 0.045 12.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_28 PF13521.6 ADV25141.1 - 0.031 14.5 0.0 0.051 13.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_3 PF07726.11 ADV25141.1 - 0.1 12.5 0.0 0.68 9.8 0.0 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PhoH PF02562.16 ADV25141.1 - 0.16 11.4 0.0 5.7 6.3 0.0 2.2 2 0 0 2 2 2 0 PhoH-like protein AAA_25 PF13481.6 ADV25141.1 - 0.18 11.4 0.0 0.44 10.1 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.6 ADV25141.1 - 0.19 12.3 0.0 0.39 11.3 0.0 1.6 1 1 0 1 1 1 0 AAA domain BUD22 PF09073.10 ADV25142.1 - 1.6 8.0 5.1 1.9 7.7 5.1 1.1 1 0 0 1 1 1 0 BUD22 Rpr2 PF04032.16 ADV25144.1 - 1.4e-13 50.9 0.5 1.4e-13 50.9 0.5 1.7 2 0 0 2 2 2 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain FANCI_S4 PF14678.6 ADV25145.1 - 0.019 14.1 2.6 0.019 14.1 0.1 2.3 2 0 0 2 2 2 0 FANCI solenoid 4 Peptidase_M35 PF02102.15 ADV25145.1 - 0.072 12.0 0.1 0.12 11.2 0.1 1.3 1 0 0 1 1 1 0 Deuterolysin metalloprotease (M35) family Scaffolding_pro PF11418.8 ADV25145.1 - 0.085 13.4 0.0 1 9.9 0.0 2.5 2 0 0 2 2 2 0 Phi29 scaffolding protein Arm PF00514.23 ADV25145.1 - 0.44 10.7 8.0 0.45 10.6 0.0 4.3 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat Nup153 PF08604.10 ADV25146.1 - 0.019 13.8 0.2 0.031 13.1 0.2 1.2 1 0 0 1 1 1 0 Nucleoporin Nup153-like DUF3915 PF13054.6 ADV25146.1 - 0.67 9.9 2.1 1.5 8.8 2.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) MAGE_N PF12440.8 ADV25146.1 - 0.82 10.4 7.4 16 6.2 6.7 2.9 2 1 0 2 2 2 0 Melanoma associated antigen family N terminal Vps39_1 PF10366.9 ADV25147.1 - 1.1e-32 112.6 1.2 1.4e-31 109.0 0.1 2.5 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 1 Vps39_2 PF10367.9 ADV25147.1 - 7.9e-30 103.5 0.4 2.3e-29 102.0 0.1 2.0 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 2 Clathrin PF00637.20 ADV25147.1 - 1e-10 41.7 4.2 4.9e-07 29.7 0.4 2.7 3 0 0 3 3 3 2 Region in Clathrin and VPS CNH PF00780.22 ADV25147.1 - 6.3e-07 29.3 0.0 0.0043 16.7 0.0 2.2 2 0 0 2 2 2 2 CNH domain PPR PF01535.20 ADV25147.1 - 0.11 12.9 0.4 49 4.5 0.0 3.7 3 0 0 3 3 3 0 PPR repeat Sm_multidrug_ex PF06695.11 ADV25147.1 - 0.11 13.2 0.0 0.27 11.9 0.0 1.6 1 0 0 1 1 1 0 Putative small multi-drug export protein TPR_1 PF00515.28 ADV25147.1 - 1.6 8.7 4.0 6.4 6.8 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat zf-C2H2 PF00096.26 ADV25148.1 - 1.4e-24 85.1 39.6 4e-06 27.0 0.2 9.5 8 0 0 8 8 8 6 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ADV25148.1 - 1e-19 69.9 46.4 8.1e-08 32.4 0.4 8.4 8 0 0 8 8 8 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 ADV25148.1 - 3.7e-09 36.6 66.8 0.0015 19.2 0.3 10.2 11 0 0 11 11 11 5 C2H2-type zinc finger FOXP-CC PF16159.5 ADV25148.1 - 6e-05 23.6 4.4 0.0048 17.5 0.1 10.1 9 3 2 11 11 11 4 FOXP coiled-coil domain zf-C2H2_6 PF13912.6 ADV25148.1 - 0.0013 18.7 13.3 0.78 9.8 0.1 6.7 6 0 0 6 6 6 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 ADV25148.1 - 0.0017 18.6 14.2 0.0088 16.3 0.0 6.0 6 0 0 6 6 6 1 Zinc-finger double-stranded RNA-binding AZUL PF16558.5 ADV25148.1 - 0.053 13.8 0.6 0.053 13.8 0.6 4.4 2 1 0 2 2 2 0 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A CCAP PF11105.8 ADV25148.1 - 3.8 7.5 5.8 6.4 6.8 0.9 2.5 1 1 1 2 2 2 0 Arthropod cardioacceleratory peptide 2a CENP-C_C PF11699.8 ADV25149.1 - 6.1e-34 116.1 0.8 1e-33 115.4 0.8 1.4 1 0 0 1 1 1 1 Mif2/CENP-C like Cupin_2 PF07883.11 ADV25149.1 - 0.00057 19.5 0.0 0.0013 18.4 0.0 1.6 1 0 0 1 1 1 1 Cupin domain DUF983 PF06170.12 ADV25150.1 - 1.7 9.1 5.9 13 6.2 0.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF983) Fapy_DNA_glyco PF01149.24 ADV25151.1 - 1.3e-30 106.4 0.0 3.4e-30 105.0 0.0 1.8 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase N-terminal domain H2TH PF06831.14 ADV25151.1 - 2.4e-18 65.9 0.0 4.9e-18 64.9 0.0 1.5 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase H2TH domain Sugar_tr PF00083.24 ADV25152.1 - 5.6e-131 437.5 22.9 6.7e-131 437.3 22.9 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ADV25152.1 - 1.4e-20 73.6 37.3 1e-16 60.9 15.5 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Brr6_like_C_C PF10104.9 ADV25152.1 - 4 7.2 8.8 0.99 9.2 1.5 2.7 3 0 0 3 3 3 0 Di-sulfide bridge nucleocytoplasmic transport domain AA_kinase PF00696.28 ADV25153.1 - 1.9e-36 125.9 0.2 3.8e-36 124.9 0.1 1.5 2 0 0 2 2 2 1 Amino acid kinase family PUA PF01472.20 ADV25153.1 - 1.5e-12 47.2 4.2 1e-05 25.4 0.2 3.5 3 1 1 4 4 4 2 PUA domain CDP-OH_P_transf PF01066.21 ADV25154.1 - 5e-12 46.4 0.5 5e-12 46.4 0.5 2.6 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase AP_endonuc_2 PF01261.24 ADV25155.1 - 4.5e-22 78.5 0.0 1.3e-21 77.0 0.0 1.7 1 1 0 1 1 1 1 Xylose isomerase-like TIM barrel adh_short_C2 PF13561.6 ADV25156.1 - 1.4e-28 100.0 0.0 4.9e-28 98.3 0.0 1.7 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ADV25156.1 - 3.4e-23 82.1 0.0 4.8e-23 81.6 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ADV25156.1 - 2.8e-05 24.1 0.0 4.2e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 KR domain Sugar_tr PF00083.24 ADV25157.1 - 1e-92 311.4 27.1 1.3e-92 311.0 27.1 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ADV25157.1 - 1e-26 93.7 34.7 1e-26 93.7 34.7 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 ADV25157.1 - 4.3e-06 25.4 5.2 4.3e-06 25.4 5.2 2.0 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Phage_holin_3_2 PF04550.12 ADV25157.1 - 0.17 12.4 8.1 0.037 14.6 3.5 2.3 2 0 0 2 2 2 0 Phage holin family 2 Fungal_trans PF04082.18 ADV25158.1 - 2.3e-09 36.7 0.0 7.9e-09 34.9 0.0 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ADV25158.1 - 7.2e-08 32.4 5.9 1.3e-07 31.6 5.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sugar_tr PF00083.24 ADV25159.1 - 1.2e-74 251.8 21.4 1.4e-74 251.6 21.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ADV25159.1 - 4.5e-26 91.6 37.7 1.7e-20 73.3 15.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2368 PF10166.9 ADV25159.1 - 0.2 11.3 2.2 13 5.4 0.1 2.7 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2368) DUF2070 PF09843.9 ADV25159.1 - 4.1 5.6 9.5 8 4.6 9.5 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) ADH_N PF08240.12 ADV25160.1 - 1.1e-28 99.2 2.6 1.6e-28 98.7 2.0 1.6 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ADV25160.1 - 1.5e-15 57.3 0.0 2.4e-15 56.7 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Pyr_redox_3 PF13738.6 ADV25160.1 - 0.0026 17.1 0.2 0.0052 16.1 0.2 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Glu_dehyd_C PF16912.5 ADV25160.1 - 0.006 16.1 0.1 0.12 11.9 0.1 2.6 2 1 0 2 2 2 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 ADV25160.1 - 0.044 14.8 0.0 0.085 13.9 0.0 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Pyr_redox_2 PF07992.14 ADV25160.1 - 0.065 12.5 0.3 0.13 11.5 0.1 1.5 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 ADV25160.1 - 0.069 12.2 0.0 0.099 11.7 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain PALP PF00291.25 ADV25160.1 - 0.085 12.3 0.2 0.12 11.8 0.2 1.2 1 0 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme FAD_binding_3 PF01494.19 ADV25160.1 - 0.099 11.9 0.0 0.16 11.2 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain 2-Hacid_dh_C PF02826.19 ADV25160.1 - 0.15 11.4 0.0 0.26 10.6 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DDE_Tnp_4 PF13359.6 ADV25161.1 - 4.2e-11 42.8 0.0 6.1e-11 42.2 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_1 PF01609.21 ADV25161.1 - 0.00016 21.4 0.0 0.00023 20.9 0.0 1.2 1 0 0 1 1 1 1 Transposase DDE domain Sugar_tr PF00083.24 ADV25162.1 - 1.4e-96 324.2 18.1 1.7e-96 323.9 18.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ADV25162.1 - 2.4e-25 89.2 17.7 2.4e-25 89.2 17.7 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily Aldo_ket_red PF00248.21 ADV25163.1 - 3.9e-44 151.0 0.0 7.5e-43 146.8 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family KDZ PF18758.1 ADV25164.1 - 9.1e-26 90.8 0.0 2e-25 89.7 0.0 1.6 1 0 0 1 1 1 1 Kyakuja-Dileera-Zisupton transposase Zn_clus PF00172.18 ADV25165.1 - 2.8e-08 33.7 10.2 4.7e-08 33.0 10.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 ADV25165.1 - 0.012 14.7 0.0 0.022 13.8 0.0 1.4 1 0 0 1 1 1 0 Fungal specific transcription factor domain L51_S25_CI-B8 PF05047.16 ADV25167.1 - 6.9e-12 45.1 0.0 9.8e-12 44.6 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain NAC PF01849.18 ADV25168.1 - 3.1e-22 78.3 0.0 7.2e-22 77.1 0.0 1.6 2 0 0 2 2 2 1 NAC domain Oxidored_FMN PF00724.20 ADV25169.1 - 1.7e-75 254.5 0.0 2.1e-75 254.1 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Peptidase_S8 PF00082.22 ADV25170.1 - 1.4e-38 132.9 0.1 2e-38 132.4 0.1 1.2 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.20 ADV25170.1 - 1.3e-28 98.8 0.2 2.7e-28 97.8 0.2 1.6 1 0 0 1 1 1 1 Proprotein convertase P-domain Peptidase_S8_N PF16361.5 ADV25170.1 - 0.00089 19.8 0.0 0.13 12.8 0.1 2.5 2 0 0 2 2 2 1 N-terminal of Subtilase family DUF1180 PF06679.12 ADV25170.1 - 0.021 15.2 0.0 0.021 15.2 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) S8_pro-domain PF16470.5 ADV25170.1 - 0.043 14.6 0.0 0.11 13.3 0.0 1.7 1 0 0 1 1 1 0 Peptidase S8 pro-domain Herpes_gE PF02480.16 ADV25170.1 - 0.11 11.2 0.0 0.18 10.5 0.0 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E DUF2914 PF11141.8 ADV25170.1 - 0.59 9.9 2.9 0.72 9.6 0.1 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2914) Elongin_A PF06881.11 ADV25171.1 - 4.4e-23 81.8 3.0 9.3e-23 80.8 3.0 1.6 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A DUF89 PF01937.19 ADV25171.1 - 0.062 12.2 0.1 0.086 11.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF89 TarH PF02203.15 ADV25171.1 - 9.3 6.1 6.4 8.1 6.3 0.2 2.3 2 0 0 2 2 2 0 Tar ligand binding domain homologue zf-C3HC4_3 PF13920.6 ADV25174.1 - 2.7e-07 30.3 4.8 4.8e-06 26.3 2.3 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ADV25174.1 - 7.3e-07 29.1 5.3 2.8e-06 27.2 2.1 2.2 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 ADV25174.1 - 2.5e-06 27.2 4.6 9.1e-05 22.2 3.5 2.3 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 ADV25174.1 - 5.3e-06 26.2 1.2 5.3e-06 26.2 1.2 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ADV25174.1 - 5.9e-06 26.2 4.1 5.9e-06 26.2 4.1 2.1 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 ADV25174.1 - 2.7e-05 23.9 5.7 5.9e-05 22.8 2.5 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ADV25174.1 - 0.00014 22.1 5.7 0.00078 19.7 2.3 2.3 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_4 PF15227.6 ADV25174.1 - 0.58 10.4 9.8 0.091 12.9 4.5 2.1 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING PPR_2 PF13041.6 ADV25175.1 - 1.3e-44 150.1 0.0 1.2e-12 47.8 0.0 12.0 10 2 2 12 12 12 9 PPR repeat family PPR PF01535.20 ADV25175.1 - 2.1e-39 131.0 13.8 1.3e-05 25.1 0.0 12.8 15 0 0 15 15 15 8 PPR repeat PPR_1 PF12854.7 ADV25175.1 - 2.3e-31 107.2 0.2 3.6e-08 33.0 0.0 8.9 10 0 0 10 10 10 6 PPR repeat PPR_3 PF13812.6 ADV25175.1 - 4e-30 103.7 0.0 3.3e-08 33.5 0.0 9.6 8 1 0 9 9 9 5 Pentatricopeptide repeat domain PPR_long PF17177.4 ADV25175.1 - 9.7e-14 51.2 0.1 1.4e-06 27.9 0.0 6.1 4 1 1 6 6 6 2 Pentacotripeptide-repeat region of PRORP TPR_4 PF07721.14 ADV25175.1 - 0.066 13.9 6.7 4.3 8.3 0.4 5.8 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_19 PF14559.6 ADV25175.1 - 1.6 9.3 5.1 4 8.0 0.0 4.3 6 0 0 6 6 6 0 Tetratricopeptide repeat Sugar_tr PF00083.24 ADV25176.1 - 3.3e-26 92.2 26.8 2.7e-24 85.8 26.8 2.2 1 1 0 1 1 1 1 Sugar (and other) transporter ATP1G1_PLM_MAT8 PF02038.16 ADV25176.1 - 4.2 6.9 12.6 3.5 7.2 0.1 4.1 4 0 0 4 4 4 0 ATP1G1/PLM/MAT8 family DUF4131 PF13567.6 ADV25176.1 - 9.1 5.9 7.7 3.1 7.4 0.2 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) FMN_dh PF01070.18 ADV25177.1 - 4.6e-119 397.5 0.0 5.8e-119 397.2 0.0 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 ADV25177.1 - 1.9e-21 75.9 0.0 7.7e-21 74.0 0.0 2.0 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.17 ADV25177.1 - 0.00019 20.7 0.0 0.0033 16.6 0.0 2.1 2 0 0 2 2 2 1 Conserved region in glutamate synthase NMO PF03060.15 ADV25177.1 - 0.00085 18.8 0.2 0.0013 18.1 0.2 1.3 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 ADV25177.1 - 0.0014 17.7 0.2 0.0038 16.3 0.2 1.7 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain ThiG PF05690.14 ADV25177.1 - 0.043 13.1 0.0 0.74 9.1 0.0 2.3 1 1 1 2 2 2 0 Thiazole biosynthesis protein ThiG dsDNA_bind PF01984.20 ADV25178.1 - 2.7e-25 88.8 1.5 3.4e-25 88.5 1.5 1.1 1 0 0 1 1 1 1 Double-stranded DNA-binding domain Tom5 PF10642.9 ADV25178.1 - 0.053 13.6 1.5 0.093 12.8 1.5 1.5 1 0 0 1 1 1 0 Mitochondrial import receptor subunit or translocase NDUF_B4 PF07225.12 ADV25178.1 - 0.1 12.5 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4) SUZ PF12752.7 ADV25178.1 - 0.34 11.7 0.4 0.34 11.7 0.4 2.6 4 0 0 4 4 4 0 SUZ domain zf-rbx1 PF12678.7 ADV25179.1 - 4.7e-13 49.2 5.3 8.3e-13 48.4 5.3 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 ADV25179.1 - 3.5e-09 36.8 10.9 1.8e-08 34.6 10.9 2.0 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 ADV25179.1 - 1.7e-07 31.0 4.4 2.9e-07 30.2 4.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ADV25179.1 - 6.5e-07 29.3 2.0 1.3e-06 28.3 2.0 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 ADV25179.1 - 3.2e-06 26.9 5.8 3.2e-06 26.9 5.8 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ADV25179.1 - 0.00015 21.7 3.9 0.00015 21.7 3.9 1.8 2 1 0 2 2 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 ADV25179.1 - 0.00045 20.0 9.2 0.00057 19.7 2.1 2.6 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 ADV25179.1 - 0.0005 19.6 2.7 0.0011 18.5 2.7 1.5 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-ANAPC11 PF12861.7 ADV25179.1 - 0.00066 19.7 5.9 0.0016 18.5 5.9 1.6 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 ADV25179.1 - 0.0013 18.4 0.7 0.0013 18.4 0.7 2.7 3 0 0 3 3 3 1 RING-like zinc finger zf-C3HC4_4 PF15227.6 ADV25179.1 - 0.0029 17.7 1.8 0.0065 16.6 1.8 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING FANCL_C PF11793.8 ADV25179.1 - 0.019 15.2 2.4 0.045 13.9 2.4 1.6 1 1 0 1 1 1 0 FANCL C-terminal domain Prok-RING_4 PF14447.6 ADV25179.1 - 0.054 13.4 5.9 0.14 12.0 6.0 1.7 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING-like PF08746.11 ADV25179.1 - 0.23 11.8 5.0 0.44 10.9 5.0 1.4 1 0 0 1 1 1 0 RING-like domain zf-RING_4 PF14570.6 ADV25179.1 - 0.28 11.0 3.4 0.15 11.8 0.9 1.8 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-C2HC5 PF06221.13 ADV25179.1 - 0.37 10.8 1.4 6.3 6.9 0.2 2.2 2 0 0 2 2 2 0 Putative zinc finger motif, C2HC5-type ABC_tran PF00005.27 ADV25180.1 - 2.8e-25 89.4 0.0 5.5e-25 88.5 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ABC2_membrane PF01061.24 ADV25180.1 - 4.8e-14 52.3 4.7 7.6e-14 51.6 4.7 1.3 1 0 0 1 1 1 1 ABC-2 type transporter AAA_21 PF13304.6 ADV25180.1 - 6e-05 23.0 0.6 0.23 11.2 0.0 2.4 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ADV25180.1 - 0.00069 19.3 0.0 0.0014 18.3 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_28 PF13521.6 ADV25180.1 - 0.00092 19.5 0.1 0.002 18.4 0.1 1.6 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 ADV25180.1 - 0.001 19.0 0.0 0.0021 18.0 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_25 PF13481.6 ADV25180.1 - 0.002 17.7 0.0 0.004 16.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 ADV25180.1 - 0.0027 17.7 0.0 0.0045 16.9 0.0 1.3 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_16 PF13191.6 ADV25180.1 - 0.0039 17.6 0.0 0.0098 16.3 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_23 PF13476.6 ADV25180.1 - 0.0052 17.3 0.0 0.011 16.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 ADV25180.1 - 0.015 15.2 0.0 0.033 14.1 0.0 1.5 1 0 0 1 1 1 0 NACHT domain Bac_DnaA PF00308.18 ADV25180.1 - 0.022 14.6 0.0 0.038 13.8 0.0 1.3 1 0 0 1 1 1 0 Bacterial dnaA protein NB-ARC PF00931.22 ADV25180.1 - 0.026 13.7 0.0 0.041 13.0 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain PRK PF00485.18 ADV25180.1 - 0.031 14.0 0.0 0.053 13.3 0.0 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family DUF87 PF01935.17 ADV25180.1 - 0.044 13.9 0.3 0.097 12.8 0.3 1.5 1 0 0 1 1 1 0 Helicase HerA, central domain cobW PF02492.19 ADV25180.1 - 0.059 13.0 0.1 0.1 12.2 0.1 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain MMR_HSR1 PF01926.23 ADV25180.1 - 0.064 13.3 0.1 0.13 12.3 0.1 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_22 PF13401.6 ADV25180.1 - 0.07 13.4 0.0 0.17 12.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 ADV25180.1 - 0.15 11.1 0.0 0.31 10.1 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_17 PF13207.6 ADV25180.1 - 0.18 12.2 0.1 0.38 11.2 0.1 1.5 1 0 0 1 1 1 0 AAA domain MeaB PF03308.16 ADV25180.1 - 0.19 10.7 0.0 0.34 9.8 0.0 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_30 PF13604.6 ADV25180.1 - 0.19 11.4 0.0 0.34 10.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 ADV25181.1 - 4.8e-18 66.0 0.0 5.6e-17 62.5 0.0 2.2 1 1 0 1 1 1 1 ABC transporter ABC2_membrane PF01061.24 ADV25181.1 - 2.9e-16 59.5 10.8 3.3e-16 59.3 9.8 1.6 2 0 0 2 2 2 1 ABC-2 type transporter AAA_21 PF13304.6 ADV25181.1 - 0.0092 15.8 0.0 0.031 14.1 0.0 1.8 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ADV25181.1 - 0.15 11.4 0.0 5.9 6.3 0.0 2.1 1 1 0 2 2 2 0 RecF/RecN/SMC N terminal domain PRT_C PF08372.10 ADV25181.1 - 0.2 11.4 0.4 1.1 9.0 0.1 2.2 2 0 0 2 2 2 0 Plant phosphoribosyltransferase C-terminal TP6A_N PF04406.14 ADV25182.1 - 7.2e-18 64.3 0.9 2.1e-17 62.8 1.0 1.8 2 0 0 2 2 2 1 Type IIB DNA topoisomerase UCR_14kD PF02271.16 ADV25182.1 - 0.0038 17.2 0.8 0.059 13.3 0.1 2.3 2 0 0 2 2 2 1 Ubiquinol-cytochrome C reductase complex 14kD subunit PBP-Tp47_a PF14889.6 ADV25182.1 - 0.095 12.3 0.1 0.17 11.5 0.1 1.4 1 0 0 1 1 1 0 Penicillin-binding protein Tp47 domain a Reovirus_cap PF00979.17 ADV25182.1 - 0.28 10.3 0.9 0.68 9.0 0.9 1.6 1 0 0 1 1 1 0 Reovirus outer capsid protein, Sigma 3 Proteasome PF00227.26 ADV25183.1 - 1.9e-56 190.5 0.1 2.7e-56 190.1 0.1 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 ADV25183.1 - 1.7e-14 53.2 0.0 3.2e-14 52.3 0.0 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Snf7 PF03357.21 ADV25184.1 - 6.7e-37 126.7 23.9 6.7e-37 126.7 23.9 1.6 2 0 0 2 2 2 1 Snf7 Exonuc_VII_L PF02601.15 ADV25184.1 - 1.6 8.2 7.1 2.2 7.8 7.1 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Peptidase_S46 PF10459.9 ADV25184.1 - 1.7 7.2 9.6 2.1 6.9 9.6 1.0 1 0 0 1 1 1 0 Peptidase S46 Fungal_trans PF04082.18 ADV25185.1 - 8.1e-18 64.4 0.1 1.5e-17 63.5 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Prefoldin_2 PF01920.20 ADV25187.1 - 1.7e-21 76.2 8.7 1.7e-21 76.2 8.7 1.4 1 1 0 1 1 1 1 Prefoldin subunit Spc7 PF08317.11 ADV25187.1 - 0.0066 15.4 8.8 0.26 10.1 0.7 2.0 2 0 0 2 2 2 2 Spc7 kinetochore protein Myosin_tail_1 PF01576.19 ADV25187.1 - 0.0078 14.1 1.1 0.0078 14.1 1.1 2.0 2 0 0 2 2 2 1 Myosin tail MCU PF04678.13 ADV25187.1 - 0.0099 16.0 1.9 0.013 15.6 1.9 1.2 1 0 0 1 1 1 1 Mitochondrial calcium uniporter NPV_P10 PF05531.12 ADV25187.1 - 0.01 16.3 3.4 1.3 9.6 0.4 2.3 2 0 0 2 2 2 1 Nucleopolyhedrovirus P10 protein PEP-utilisers_N PF05524.13 ADV25187.1 - 0.013 15.7 4.2 0.094 12.9 0.6 2.1 1 1 1 2 2 2 0 PEP-utilising enzyme, N-terminal DMPK_coil PF08826.10 ADV25187.1 - 0.022 14.9 14.6 0.13 12.4 4.5 2.2 2 0 0 2 2 2 0 DMPK coiled coil domain like XhlA PF10779.9 ADV25187.1 - 0.024 14.8 1.4 0.024 14.8 1.4 1.8 2 1 0 2 2 2 0 Haemolysin XhlA TBCC_N PF16752.5 ADV25187.1 - 0.026 15.0 6.6 0.33 11.4 0.9 2.1 2 0 0 2 2 2 0 Tubulin-specific chaperone C N-terminal domain Fez1 PF06818.15 ADV25187.1 - 0.034 14.6 8.6 0.83 10.1 2.2 2.0 1 1 1 2 2 2 0 Fez1 DHR10 PF18595.1 ADV25187.1 - 0.056 13.5 1.0 0.056 13.5 1.0 2.1 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain EzrA PF06160.12 ADV25187.1 - 0.069 11.3 10.1 0.013 13.7 3.6 2.0 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA ABC_tran_CTD PF16326.5 ADV25187.1 - 0.1 12.8 12.7 0.27 11.5 4.2 2.7 2 1 1 3 3 3 0 ABC transporter C-terminal domain APG6_N PF17675.1 ADV25187.1 - 0.13 12.8 13.9 0.32 11.5 6.5 2.0 1 1 1 2 2 2 0 Apg6 coiled-coil region Atg14 PF10186.9 ADV25187.1 - 0.19 10.8 5.2 0.24 10.4 5.2 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Snapin_Pallidin PF14712.6 ADV25187.1 - 0.21 12.0 6.1 2.6 8.5 0.2 2.7 2 1 0 2 2 2 0 Snapin/Pallidin CC2-LZ PF16516.5 ADV25187.1 - 0.29 11.5 9.1 0.52 10.7 1.7 2.2 2 0 0 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Prefoldin_3 PF13758.6 ADV25187.1 - 0.3 11.1 5.2 0.18 11.9 2.6 1.9 2 1 0 2 2 1 0 Prefoldin subunit YgaB PF14182.6 ADV25187.1 - 0.36 11.2 8.1 0.19 12.2 2.9 2.2 2 0 0 2 2 2 0 YgaB-like protein FlaC_arch PF05377.11 ADV25187.1 - 0.4 11.1 4.6 3.9 7.9 0.8 2.9 2 2 0 2 2 2 0 Flagella accessory protein C (FlaC) Prefoldin PF02996.17 ADV25187.1 - 0.42 10.5 12.1 0.078 12.9 4.9 2.3 2 1 0 2 2 2 0 Prefoldin subunit Nsp1_C PF05064.13 ADV25187.1 - 0.46 10.3 8.9 2.8 7.8 1.2 2.1 1 1 1 2 2 2 0 Nsp1-like C-terminal region DUF641 PF04859.12 ADV25187.1 - 0.57 10.5 7.2 0.52 10.6 3.4 2.0 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) ADIP PF11559.8 ADV25187.1 - 0.65 10.1 8.5 0.23 11.5 1.7 2.1 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding End3 PF12761.7 ADV25187.1 - 0.74 10.0 7.9 3.1 7.9 7.9 1.8 1 1 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 ATG16 PF08614.11 ADV25187.1 - 0.85 9.8 9.8 3.2 7.9 1.8 2.1 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) DUF4200 PF13863.6 ADV25187.1 - 0.86 10.0 10.8 0.59 10.5 4.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) Sec8_exocyst PF04048.14 ADV25187.1 - 1.1 9.2 7.2 0.72 9.7 1.3 2.1 1 1 1 2 2 2 0 Sec8 exocyst complex component specific domain DUF4349 PF14257.6 ADV25187.1 - 1.1 8.7 7.0 0.15 11.5 1.5 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4349) Tropomyosin_1 PF12718.7 ADV25187.1 - 1.2 9.3 10.6 1 9.5 2.7 2.2 2 0 0 2 2 2 0 Tropomyosin like CENP-F_leu_zip PF10473.9 ADV25187.1 - 1.3 9.1 12.0 1.2 9.1 3.3 2.1 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Cluap1 PF10234.9 ADV25187.1 - 1.3 8.3 9.3 0.24 10.8 3.6 1.8 1 1 0 2 2 2 0 Clusterin-associated protein-1 FlxA PF14282.6 ADV25187.1 - 1.4 9.0 13.7 0.39 10.7 4.6 2.2 2 0 0 2 2 2 0 FlxA-like protein DUF4140 PF13600.6 ADV25187.1 - 1.5 9.3 7.2 0.91 10.0 1.2 2.3 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF1664 PF07889.12 ADV25187.1 - 1.6 8.8 4.5 3.1 7.9 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) YabA PF06156.13 ADV25187.1 - 1.6 9.4 7.6 7.2 7.3 0.8 2.1 1 1 0 2 2 2 0 Initiation control protein YabA Fib_alpha PF08702.10 ADV25187.1 - 4.4 7.5 9.3 44 4.2 9.3 2.0 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family TolA_bind_tri PF16331.5 ADV25187.1 - 4.7 7.3 9.5 2.6 8.2 1.8 3.0 2 2 1 3 3 3 0 TolA binding protein trimerisation Csm1_N PF18504.1 ADV25187.1 - 5 7.5 11.0 3 8.3 1.8 3.3 2 2 0 2 2 2 0 Csm1 N-terminal domain IBN_N PF03810.19 ADV25188.1 - 1.2e-06 28.3 0.7 0.0001 22.1 0.0 3.2 3 0 0 3 3 3 1 Importin-beta N-terminal domain Alpha_Helical PF18489.1 ADV25188.1 - 0.092 12.9 0.1 0.41 10.8 0.0 2.0 2 0 0 2 2 2 0 Alpha helical domain Dor1 PF04124.12 ADV25189.1 - 8.4e-64 215.4 4.5 1.2e-63 214.8 4.5 1.2 1 0 0 1 1 1 1 Dor1-like family Vps51 PF08700.11 ADV25189.1 - 2.9e-05 24.1 0.8 0.00049 20.1 0.0 3.0 4 0 0 4 4 4 1 Vps51/Vps67 Vps54_N PF10475.9 ADV25189.1 - 0.0022 17.4 0.2 0.0037 16.6 0.2 1.4 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex Sec5 PF15469.6 ADV25189.1 - 0.094 12.5 0.1 0.2 11.4 0.1 1.6 1 0 0 1 1 1 0 Exocyst complex component Sec5 Atg14 PF10186.9 ADV25190.1 - 3.2e-54 184.2 2.3 4.2e-54 183.8 2.3 1.1 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 RsbU_N PF08673.10 ADV25190.1 - 0.079 13.1 0.0 0.17 12.0 0.0 1.5 1 0 0 1 1 1 0 Phosphoserine phosphatase RsbU, N-terminal domain DUF641 PF04859.12 ADV25190.1 - 0.14 12.5 1.3 0.24 11.7 0.9 1.6 1 1 0 1 1 1 0 Plant protein of unknown function (DUF641) DUF4698 PF15769.5 ADV25190.1 - 0.14 11.2 3.6 0.24 10.4 3.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4698) DUF4407 PF14362.6 ADV25190.1 - 0.2 11.0 1.4 0.29 10.4 1.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Spc7 PF08317.11 ADV25190.1 - 0.42 9.4 4.0 0.6 8.9 3.1 1.4 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF1996 PF09362.10 ADV25191.1 - 4e-59 200.5 1.8 6e-59 199.9 1.8 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) OppC_N PF12911.7 ADV25191.1 - 0.046 13.7 0.1 0.11 12.5 0.1 1.6 1 0 0 1 1 1 0 N-terminal TM domain of oligopeptide transport permease C PTPA PF03095.15 ADV25192.1 - 2.5e-121 404.8 0.0 2.9e-121 404.6 0.0 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein Ribosomal_S8 PF00410.19 ADV25193.1 - 2.3e-07 30.8 0.0 9.4e-05 22.4 0.0 2.1 2 0 0 2 2 2 2 Ribosomal protein S8 IGPD PF00475.18 ADV25194.1 - 1.6e-62 210.1 0.8 5e-62 208.5 0.7 1.7 2 0 0 2 2 2 1 Imidazoleglycerol-phosphate dehydratase AAA PF00004.29 ADV25195.1 - 5.1e-34 117.5 0.0 9.3e-34 116.7 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ADV25195.1 - 9.6e-10 38.1 0.0 2.5e-09 36.8 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 ADV25195.1 - 0.00021 21.7 0.0 0.043 14.2 0.0 3.1 2 0 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 ADV25195.1 - 0.00098 19.1 0.0 0.0045 17.0 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ADV25195.1 - 0.0021 18.3 0.0 0.029 14.6 0.0 2.4 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 ADV25195.1 - 0.0045 16.7 0.0 0.02 14.7 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain IstB_IS21 PF01695.17 ADV25195.1 - 0.016 15.0 0.0 0.051 13.3 0.0 1.7 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_33 PF13671.6 ADV25195.1 - 0.039 14.1 0.0 0.084 13.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 ADV25195.1 - 0.097 12.0 0.1 0.26 10.6 0.1 1.7 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI PhoH PF02562.16 ADV25195.1 - 0.18 11.2 0.2 0.36 10.2 0.2 1.4 1 0 0 1 1 1 0 PhoH-like protein DUF815 PF05673.13 ADV25195.1 - 0.2 10.8 0.0 0.36 9.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) SHR3_chaperone PF08229.11 ADV25197.1 - 2e-32 111.7 0.0 2.3e-32 111.5 0.0 1.0 1 0 0 1 1 1 1 ER membrane protein SH3 Bot1p PF12298.8 ADV25199.1 - 3.1e-19 69.8 0.3 6.6e-19 68.7 0.3 1.5 1 0 0 1 1 1 1 Eukaryotic mitochondrial regulator protein DUF563 PF04577.14 ADV25199.1 - 1.3e-10 41.8 0.1 1.1e-07 32.2 0.1 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF563) LIM PF00412.22 ADV25200.1 - 9.8e-32 109.0 27.5 8.4e-15 54.8 5.2 4.4 4 0 0 4 4 4 4 LIM domain Lipase_GDSL_2 PF13472.6 ADV25200.1 - 2.8e-13 50.6 0.0 1.1e-10 42.2 0.0 3.3 3 1 1 4 4 4 2 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 ADV25200.1 - 9.8e-10 38.7 0.0 1.7e-07 31.5 0.0 2.4 2 0 0 2 2 2 2 GDSL-like Lipase/Acylhydrolase C1_4 PF07975.12 ADV25200.1 - 9.1 6.6 20.3 0.35 11.1 1.1 3.5 3 1 1 4 4 4 0 TFIIH C1-like domain DUF3455 PF11937.8 ADV25201.1 - 5.5e-16 59.3 0.1 1.1e-15 58.4 0.1 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF3455) SH3_1 PF00018.28 ADV25202.1 - 2.6e-08 33.3 0.0 4.7e-08 32.5 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ADV25202.1 - 5.6e-06 26.1 0.0 1.3e-05 25.0 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 ADV25202.1 - 0.00035 20.2 0.0 0.00098 18.8 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 ADV25202.1 - 0.0076 16.5 0.0 0.017 15.4 0.0 1.6 1 0 0 1 1 1 1 Bacterial SH3 domain ILVD_EDD PF00920.21 ADV25203.1 - 1.3e-204 680.7 0.1 1.5e-204 680.4 0.1 1.1 1 0 0 1 1 1 1 Dehydratase family HMGL-like PF00682.19 ADV25204.1 - 3.5e-71 239.9 0.0 4.6e-71 239.5 0.0 1.2 1 0 0 1 1 1 1 HMGL-like LeuA_dimer PF08502.10 ADV25204.1 - 1.2e-23 83.5 0.6 2.9e-23 82.2 0.2 1.8 2 0 0 2 2 2 1 LeuA allosteric (dimerisation) domain GCD14 PF08704.10 ADV25205.1 - 1.6e-81 273.6 0.0 7.5e-81 271.4 0.0 1.9 1 1 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltransf_31 PF13847.6 ADV25205.1 - 7.4e-08 32.3 0.0 1.2e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain GCD14_N PF14801.6 ADV25205.1 - 5.1e-07 29.4 0.0 8.9e-07 28.6 0.0 1.4 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit N-term PCMT PF01135.19 ADV25205.1 - 2e-06 27.7 0.0 3.4e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_4 PF02390.17 ADV25205.1 - 1.9e-05 24.2 0.5 0.00011 21.7 0.0 2.1 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_25 PF13649.6 ADV25205.1 - 0.00093 19.9 0.0 0.0019 18.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ADV25205.1 - 0.0037 16.6 0.0 0.006 16.0 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Gcd10p PF04189.13 ADV25205.1 - 0.068 12.3 0.0 0.14 11.2 0.0 1.5 1 0 0 1 1 1 0 Gcd10p family DUF3586 PF12131.8 ADV25205.1 - 0.3 11.3 2.4 0.74 10.1 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3586) Pkinase PF00069.25 ADV25206.1 - 3.1e-57 194.0 0.0 1.3e-51 175.5 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ADV25206.1 - 5.4e-35 120.9 0.0 2.1e-33 115.7 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 ADV25206.1 - 1e-05 25.0 0.0 1.7e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 ADV25206.1 - 0.0075 15.1 0.4 0.14 10.9 0.0 2.6 3 0 0 3 3 3 1 Fungal protein kinase PACT_coil_coil PF10495.9 ADV25206.1 - 0.031 14.9 0.1 0.84 10.3 0.0 2.4 2 0 0 2 2 2 0 Pericentrin-AKAP-450 domain of centrosomal targeting protein Kdo PF06293.14 ADV25206.1 - 0.033 13.5 0.0 0.062 12.7 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ADV25206.1 - 0.038 13.9 0.2 0.22 11.4 0.1 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.9 ADV25206.1 - 0.12 11.9 0.0 0.23 11.0 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Hexokinase_2 PF03727.16 ADV25208.1 - 4.7e-82 275.0 0.0 6.7e-82 274.5 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 ADV25208.1 - 5.4e-65 219.0 0.0 8.2e-65 218.4 0.0 1.3 1 0 0 1 1 1 1 Hexokinase Thioredoxin PF00085.20 ADV25209.1 - 5.2e-46 154.9 0.0 7e-23 80.6 0.0 2.6 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.6 ADV25209.1 - 2.8e-14 53.4 0.0 3.8e-08 33.5 0.0 3.2 3 0 0 3 3 3 3 Thioredoxin-like domain Thioredoxin_2 PF13098.6 ADV25209.1 - 5.9e-05 23.5 0.0 0.63 10.5 0.0 3.2 3 1 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_4 PF13462.6 ADV25209.1 - 0.00019 21.6 0.3 3.7 7.7 0.2 3.5 3 1 0 3 3 3 2 Thioredoxin Thioredoxin_8 PF13905.6 ADV25209.1 - 0.00037 20.8 0.0 0.14 12.5 0.0 3.7 4 0 0 4 4 4 1 Thioredoxin-like AhpC-TSA PF00578.21 ADV25209.1 - 0.0029 17.5 0.1 0.2 11.6 0.0 2.4 2 0 0 2 2 2 1 AhpC/TSA family Thioredoxin_7 PF13899.6 ADV25209.1 - 0.0094 16.1 0.1 0.097 12.9 0.0 2.5 2 0 0 2 2 2 1 Thioredoxin-like Thioredoxin_9 PF14595.6 ADV25209.1 - 0.12 12.2 0.0 10 5.9 0.0 2.5 2 0 0 2 2 2 0 Thioredoxin OST3_OST6 PF04756.13 ADV25209.1 - 0.15 11.4 0.2 1.8 7.8 0.0 2.6 4 0 0 4 4 4 0 OST3 / OST6 family, transporter family DUF5049 PF16468.5 ADV25209.1 - 0.19 11.6 0.1 0.38 10.7 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5049) DDE_Tnp_1_2 PF13586.6 ADV25209.1 - 0.19 12.1 0.0 4.8 7.6 0.0 2.7 3 0 0 3 3 3 0 Transposase DDE domain IBR PF01485.21 ADV25210.1 - 1.3e-06 28.5 28.4 6.4e-05 23.1 5.4 3.4 3 0 0 3 3 3 2 IBR domain, a half RING-finger domain TRAF6_Z2 PF18048.1 ADV25210.1 - 1.8 8.8 5.0 8.4 6.6 0.0 2.7 2 0 0 2 2 2 0 TNF receptor-associated factor 6 zinc finger 2 Rrp15p PF07890.12 ADV25211.1 - 1.7e-24 86.7 11.3 1.7e-24 86.7 11.3 2.3 2 1 0 2 2 2 1 Rrp15p Noc2 PF03715.13 ADV25212.1 - 5.7e-112 373.8 0.0 9e-112 373.2 0.0 1.3 1 0 0 1 1 1 1 Noc2p family Nop14 PF04147.12 ADV25212.1 - 0.0011 17.3 0.0 0.0011 17.3 0.0 3.3 2 1 1 3 3 3 1 Nop14-like family TruB_N PF01509.18 ADV25212.1 - 0.057 13.8 0.0 0.18 12.2 0.0 1.8 1 0 0 1 1 1 0 TruB family pseudouridylate synthase (N terminal domain) Glyco_hydro_31 PF01055.26 ADV25213.1 - 2.8e-138 461.8 3.0 3.5e-138 461.5 3.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 ADV25213.1 - 2.3e-34 118.0 0.0 6.2e-34 116.7 0.0 1.7 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Gal_mutarotas_2 PF13802.6 ADV25213.1 - 1.7e-07 31.5 0.1 5.8e-07 29.7 0.1 2.0 1 0 0 1 1 1 1 Galactose mutarotase-like AP_endonuc_2 PF01261.24 ADV25214.1 - 7.6e-28 97.4 0.0 1.3e-27 96.6 0.0 1.3 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel HpaB_N PF11794.8 ADV25214.1 - 0.026 14.2 0.0 0.046 13.4 0.0 1.3 1 0 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase N terminal WD40 PF00400.32 ADV25216.1 - 4.9e-44 147.4 25.3 6.3e-08 33.2 1.6 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV25216.1 - 2e-11 44.0 0.6 0.04 14.2 0.0 5.0 1 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ADV25216.1 - 0.0011 17.7 7.1 0.099 11.3 0.1 4.1 5 0 0 5 5 5 2 Nucleoporin Nup120/160 DUF1513 PF07433.11 ADV25216.1 - 0.0061 15.7 0.0 0.19 10.7 0.0 2.8 2 1 1 3 3 3 1 Protein of unknown function (DUF1513) IKI3 PF04762.12 ADV25216.1 - 0.042 11.9 0.0 3.8 5.4 0.0 2.4 2 1 0 2 2 2 0 IKI3 family PD40 PF07676.12 ADV25216.1 - 0.047 13.6 1.5 17 5.5 0.0 4.7 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat NAD_binding_1 PF00175.21 ADV25218.1 - 2.7e-26 92.4 0.0 5.6e-26 91.3 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 ADV25218.1 - 3.3e-16 59.5 0.0 1e-15 57.9 0.0 1.9 1 1 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 ADV25218.1 - 0.0011 19.1 0.0 0.11 12.6 0.0 2.3 2 0 0 2 2 2 2 Ferric reductase NAD binding domain ApbA_C PF08546.11 ADV25219.1 - 6.9e-26 90.9 0.0 1.1e-25 90.2 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 ADV25219.1 - 1.4e-17 63.8 0.2 1.5e-16 60.4 0.2 2.1 1 1 0 1 1 1 1 Ketopantoate reductase PanE/ApbA eIF-1a PF01176.19 ADV25221.1 - 4.2e-20 71.3 0.1 5.7e-20 70.9 0.1 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 F-box-like PF12937.7 ADV25222.1 - 9.8e-07 28.6 0.4 2.7e-06 27.2 0.4 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ADV25222.1 - 1.6e-06 27.9 0.4 4.7e-06 26.4 0.3 1.9 1 1 0 1 1 1 1 F-box domain PVL_ORF50 PF07768.11 ADV25223.1 - 8.1 6.8 6.9 5.1 7.4 1.4 2.3 2 0 0 2 2 2 0 PVL ORF-50-like family UNC45-central PF11701.8 ADV25224.1 - 5e-26 91.5 0.0 1.1e-25 90.3 0.0 1.6 1 0 0 1 1 1 1 Myosin-binding striated muscle assembly central Choline_transpo PF04515.12 ADV25225.1 - 0.012 14.9 0.6 0.012 14.9 0.6 1.7 2 0 0 2 2 2 0 Plasma-membrane choline transporter DUF5325 PF17259.2 ADV25225.1 - 0.28 11.1 1.5 0.51 10.3 0.0 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5325) DUF2897 PF11446.8 ADV25225.1 - 0.31 10.9 1.4 0.63 10.0 1.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2897) TBP PF00352.21 ADV25226.1 - 5.7e-66 218.5 0.1 9.7e-33 112.0 0.0 2.1 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 ADV25226.1 - 6.4e-06 26.2 0.0 0.079 13.1 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) DUF676 PF05057.14 ADV25227.1 - 1.5e-27 96.6 0.0 8.9e-27 94.0 0.0 1.9 1 1 0 1 1 1 1 Putative serine esterase (DUF676) Palm_thioest PF02089.15 ADV25227.1 - 0.028 14.2 0.0 0.047 13.5 0.0 1.4 1 0 0 1 1 1 0 Palmitoyl protein thioesterase Putative_PNPOx PF01243.20 ADV25228.1 - 3.2e-23 81.7 0.0 5e-23 81.1 0.0 1.3 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase PNP_phzG_C PF10590.9 ADV25228.1 - 4.9e-20 71.3 4.2 1.5e-19 69.8 4.2 1.9 1 0 0 1 1 1 1 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region Pyridox_oxase_2 PF12766.7 ADV25228.1 - 0.0001 22.8 0.0 0.00019 22.0 0.0 1.5 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyrid_ox_like PF16242.5 ADV25228.1 - 0.034 13.7 0.0 0.079 12.6 0.0 1.5 2 0 0 2 2 2 0 Pyridoxamine 5'-phosphate oxidase like Pkinase PF00069.25 ADV25229.1 - 1e-72 244.7 0.0 1.3e-72 244.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV25229.1 - 5.7e-37 127.4 0.0 7.2e-37 127.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ADV25229.1 - 1.2e-06 27.6 0.0 0.00036 19.4 0.0 2.3 2 0 0 2 2 2 2 Fungal protein kinase Kinase-like PF14531.6 ADV25229.1 - 5.6e-05 22.6 0.0 0.0001 21.7 0.0 1.4 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 ADV25229.1 - 0.0024 17.3 0.1 0.0058 16.0 0.1 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family TetR_C_27 PF17935.1 ADV25229.1 - 0.064 13.3 0.0 0.23 11.5 0.0 1.8 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Sec66 PF09802.9 ADV25230.1 - 0.021 14.4 1.8 0.04 13.5 1.8 1.4 1 0 0 1 1 1 0 Preprotein translocase subunit Sec66 Hamartin PF04388.12 ADV25230.1 - 0.19 10.4 3.1 0.2 10.3 3.1 1.2 1 0 0 1 1 1 0 Hamartin protein Macoilin PF09726.9 ADV25230.1 - 0.25 9.8 6.6 0.3 9.6 6.6 1.2 1 0 0 1 1 1 0 Macoilin family Presenilin PF01080.17 ADV25230.1 - 0.4 9.4 3.8 0.54 9.0 3.8 1.2 1 0 0 1 1 1 0 Presenilin DUF1676 PF07898.13 ADV25230.1 - 7.5 6.6 8.0 17 5.4 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1676) Sec8_exocyst PF04048.14 ADV25234.1 - 1.1e-14 54.5 0.6 1e-13 51.4 0.0 2.8 3 0 0 3 3 3 1 Sec8 exocyst complex component specific domain Ribosomal_S26e PF01283.19 ADV25235.1 - 1e-51 173.9 5.3 1.2e-51 173.6 5.3 1.1 1 0 0 1 1 1 1 Ribosomal protein S26e zf_CopZ PF18423.1 ADV25235.1 - 0.011 15.6 0.1 0.022 14.7 0.1 1.5 1 0 0 1 1 1 0 Zinc binding domain SEN1_N PF12726.7 ADV25236.1 - 2.4e-178 594.8 0.3 4e-178 594.1 0.3 1.4 1 0 0 1 1 1 1 SEN1 N terminal AAA_11 PF13086.6 ADV25236.1 - 9.9e-66 222.2 0.5 2.8e-65 220.7 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_12 PF13087.6 ADV25236.1 - 5.8e-60 202.3 0.0 1.1e-59 201.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 ADV25236.1 - 4.1e-06 26.6 0.0 2.2e-05 24.3 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 ADV25236.1 - 3.5e-05 24.2 0.4 8.6e-05 22.9 0.0 1.9 2 0 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.18 ADV25236.1 - 0.001 18.9 0.0 0.2 11.4 0.0 3.5 3 1 0 3 3 3 1 Viral (Superfamily 1) RNA helicase AAA PF00004.29 ADV25236.1 - 0.15 12.5 0.3 1.2 9.6 0.1 2.7 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) NIF PF03031.18 ADV25237.1 - 1.7e-10 40.9 0.0 5.4e-09 36.0 0.0 3.0 2 1 0 2 2 2 1 NLI interacting factor-like phosphatase ERCC4 PF02732.15 ADV25238.1 - 1.8e-18 67.2 0.0 6.1e-18 65.5 0.0 1.9 1 0 0 1 1 1 1 ERCC4 domain Aminotran_1_2 PF00155.21 ADV25239.1 - 1.8e-41 142.5 0.0 2.3e-41 142.2 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 ADV25239.1 - 0.018 14.3 0.0 0.028 13.7 0.0 1.2 1 0 0 1 1 1 0 Beta-eliminating lyase Aldo_ket_red PF00248.21 ADV25240.1 - 1.3e-48 165.7 0.0 1.4e-48 165.6 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Methyltransf_12 PF08242.12 ADV25241.1 - 0.094 13.5 0.0 0.3 11.9 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain DnaJ PF00226.31 ADV25242.1 - 3.7e-14 52.6 1.4 3.7e-14 52.6 1.4 2.2 2 0 0 2 2 2 1 DnaJ domain SRR1 PF07985.12 ADV25242.1 - 2.6e-13 49.8 0.0 6.3e-13 48.5 0.0 1.7 1 0 0 1 1 1 1 SRR1 zf-C2H2_jaz PF12171.8 ADV25242.1 - 2.6e-10 40.3 0.6 5.3e-10 39.3 0.6 1.6 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 ADV25242.1 - 8.9e-08 32.3 0.6 1.8e-07 31.3 0.6 1.6 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 ADV25242.1 - 0.03 14.3 0.3 0.057 13.4 0.3 1.5 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2_2 PF12756.7 ADV25242.1 - 0.04 14.2 0.0 0.11 12.9 0.0 1.6 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) Phage_int_SAM_4 PF13495.6 ADV25242.1 - 0.059 13.9 0.4 0.17 12.3 0.4 1.8 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain zf-C2H2_4 PF13894.6 ADV25242.1 - 0.069 14.0 0.1 0.2 12.6 0.1 1.9 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2 PF00096.26 ADV25242.1 - 0.21 12.1 0.1 0.49 10.9 0.1 1.7 1 0 0 1 1 1 0 Zinc finger, C2H2 type ArAE_2 PF10334.9 ADV25243.1 - 2.2e-65 220.7 0.0 3.8e-65 219.9 0.0 1.4 1 0 0 1 1 1 1 Aromatic acid exporter family member 2 ArAE_2_N PF10337.9 ADV25243.1 - 4.4e-55 187.6 0.0 6.1e-53 180.5 0.0 3.2 2 1 0 2 2 2 1 Putative ER transporter, 6TM, N-terminal FUSC_2 PF13515.6 ADV25243.1 - 2.7e-07 30.7 12.5 2.7e-07 30.7 12.5 3.2 3 0 0 3 3 3 1 Fusaric acid resistance protein-like DUF2929 PF11151.8 ADV25243.1 - 4.2 7.7 6.5 2.5 8.5 0.7 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2929) DUF1772 PF08592.11 ADV25244.1 - 1.1e-14 54.9 0.9 1.5e-14 54.5 0.8 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF1772) DUF2012 PF09430.10 ADV25245.1 - 6.7e-29 100.5 0.0 9.4e-29 100.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2012) rhaM PF05336.13 ADV25246.1 - 8.7e-35 119.1 0.1 1e-34 118.9 0.1 1.0 1 0 0 1 1 1 1 L-rhamnose mutarotase Pkinase PF00069.25 ADV25247.1 - 9.9e-71 238.2 0.0 1.2e-70 237.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV25247.1 - 4.8e-33 114.5 0.0 7.3e-33 113.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 ADV25247.1 - 0.00016 20.7 0.0 0.00025 20.1 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 ADV25247.1 - 0.00055 19.3 0.0 0.0011 18.3 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 ADV25247.1 - 0.057 12.8 0.1 0.11 11.9 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 ADV25247.1 - 0.071 12.7 1.8 0.45 10.1 1.8 2.0 1 1 0 1 1 1 0 RIO1 family Mid2 PF04478.12 ADV25248.1 - 0.0026 17.6 0.7 0.0026 17.6 0.7 3.1 2 1 1 3 3 3 1 Mid2 like cell wall stress sensor Adeno_E3_CR2 PF02439.15 ADV25248.1 - 0.18 11.6 0.0 0.35 10.7 0.0 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 TFIIA PF03153.13 ADV25248.1 - 0.19 11.7 9.9 0.094 12.7 7.6 1.6 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit TAF4 PF05236.14 ADV25249.1 - 6.5e-08 32.7 18.1 5.1e-07 29.7 18.1 2.1 1 1 0 1 1 1 1 Transcription initiation factor TFIID component TAF4 family DUF2894 PF11445.8 ADV25249.1 - 0.013 15.9 8.4 0.013 15.9 8.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2894) MMM1 PF10296.9 ADV25251.1 - 7.8e-60 202.7 0.1 1.7e-50 171.9 0.0 3.1 1 1 1 2 2 2 2 Maintenance of mitochondrial morphology protein 1 SMP_LBD PF17047.5 ADV25251.1 - 0.25 10.8 0.2 0.55 9.7 0.1 1.6 2 0 0 2 2 2 0 Synaptotagmin-like mitochondrial-lipid-binding domain Sec39 PF08314.11 ADV25252.1 - 4.8e-36 124.5 0.0 7.6e-29 100.7 0.0 2.3 1 1 1 2 2 2 2 Secretory pathway protein Sec39 L_biotic_typeA PF04604.13 ADV25252.1 - 0.14 12.0 0.1 0.4 10.6 0.1 1.7 1 0 0 1 1 1 0 Type-A lantibiotic Beta_helix PF13229.6 ADV25253.1 - 2e-11 44.0 0.1 5.6e-11 42.5 0.1 1.7 1 1 0 1 1 1 1 Right handed beta helix region NosD PF05048.13 ADV25253.1 - 0.014 14.7 0.0 0.12 11.7 0.0 2.1 1 1 0 2 2 2 0 Periplasmic copper-binding protein (NosD) Disaggr_assoc PF08480.10 ADV25253.1 - 0.16 11.8 0.1 0.32 10.9 0.1 1.4 1 0 0 1 1 1 0 Disaggregatase related SRP-alpha_N PF04086.13 ADV25254.1 - 2.3 8.1 8.6 4.5 7.1 8.6 1.4 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Pex2_Pex12 PF04757.14 ADV25255.1 - 3.6e-22 79.1 0.5 4.6e-22 78.7 0.5 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-RING_5 PF14634.6 ADV25255.1 - 1.8e-08 34.2 2.4 3e-08 33.5 2.4 1.3 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 ADV25255.1 - 2.4e-07 30.5 2.0 3.9e-07 29.8 2.0 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 ADV25255.1 - 4.2e-07 30.2 2.3 7.3e-07 29.4 2.3 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 ADV25255.1 - 4.3e-07 29.7 2.0 7.2e-07 29.0 2.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ADV25255.1 - 0.00017 21.5 2.6 0.00077 19.4 2.6 2.1 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 ADV25255.1 - 0.0008 19.2 6.0 0.0025 17.6 6.0 1.9 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ADV25255.1 - 0.0008 19.2 1.8 0.0016 18.3 1.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 ADV25255.1 - 0.015 15.0 1.5 0.023 14.5 1.5 1.3 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.7 ADV25255.1 - 0.026 14.8 1.5 0.066 13.5 1.5 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain TerY_C PF15616.6 ADV25255.1 - 0.063 13.4 2.2 0.11 12.6 2.2 1.3 1 0 0 1 1 1 0 TerY-C metal binding domain zf-RING_11 PF17123.5 ADV25255.1 - 0.07 12.9 0.3 0.07 12.9 0.3 1.7 2 0 0 2 2 2 0 RING-like zinc finger IBR PF01485.21 ADV25255.1 - 0.089 13.0 1.9 0.22 11.8 2.0 1.6 1 1 0 1 1 1 0 IBR domain, a half RING-finger domain zf-RING_10 PF16685.5 ADV25255.1 - 0.13 12.4 0.8 0.27 11.4 0.8 1.4 1 0 0 1 1 1 0 zinc RING finger of MSL2 Metallophos PF00149.28 ADV25257.1 - 4e-12 47.1 0.0 7.8e-12 46.1 0.0 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase FBPase_2 PF06874.11 ADV25257.1 - 0.0045 15.4 0.2 0.35 9.1 0.0 2.3 2 0 0 2 2 2 2 Firmicute fructose-1,6-bisphosphatase Metallophos_3 PF14582.6 ADV25257.1 - 0.057 12.7 0.1 0.093 12.0 0.1 1.3 1 0 0 1 1 1 0 Metallophosphoesterase, calcineurin superfamily Metallophos_2 PF12850.7 ADV25257.1 - 0.061 13.5 0.0 0.1 12.8 0.0 1.4 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain DRIM PF07539.12 ADV25259.1 - 2.9e-172 574.3 0.2 2.9e-172 574.3 0.2 4.2 4 0 0 4 4 4 2 Down-regulated in metastasis RTP1_C1 PF10363.9 ADV25259.1 - 0.0078 16.4 0.1 8.7 6.6 0.0 4.2 3 0 0 3 3 3 1 Required for nuclear transport of RNA pol II C-terminus 1 Dopey_N PF04118.14 ADV25259.1 - 0.02 14.0 1.1 6.4 5.8 0.0 4.0 3 0 0 3 3 3 0 Dopey, N-terminal Adaptin_N PF01602.20 ADV25259.1 - 1.1 7.7 4.8 6.7 5.1 0.0 4.1 6 0 0 6 6 6 0 Adaptin N terminal region MMS19_N PF14500.6 ADV25259.1 - 1.8 8.1 11.8 0.46 10.0 0.5 5.0 4 1 1 5 5 5 0 Dos2-interacting transcription regulator of RNA-Pol-II COX17 PF05051.13 ADV25260.1 - 8.2e-23 80.5 4.6 1e-22 80.2 4.6 1.1 1 0 0 1 1 1 1 Cytochrome C oxidase copper chaperone (COX17) CEND1 PF15677.5 ADV25260.1 - 0.036 14.6 0.4 0.038 14.5 0.4 1.1 1 0 0 1 1 1 0 Cell cycle exit and neuronal differentiation protein 1 TENA_THI-4 PF03070.16 ADV25261.1 - 7.8e-10 38.9 0.5 0.00033 20.5 0.2 2.3 2 0 0 2 2 2 2 TENA/THI-4/PQQC family DUF747 PF05346.11 ADV25262.1 - 1.4e-108 363.2 1.5 1.8e-108 362.8 1.5 1.1 1 0 0 1 1 1 1 Eukaryotic membrane protein family G-patch PF01585.23 ADV25263.1 - 1.4e-14 53.7 1.2 2.9e-14 52.7 1.2 1.6 1 0 0 1 1 1 1 G-patch domain RRM_1 PF00076.22 ADV25263.1 - 1.3e-07 31.3 0.0 0.00037 20.3 0.1 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) G-patch_2 PF12656.7 ADV25263.1 - 1.4e-05 25.1 1.3 3.8e-05 23.7 1.3 1.8 1 0 0 1 1 1 1 G-patch domain zf-C2H2_jaz PF12171.8 ADV25263.1 - 0.0058 16.9 0.3 0.011 16.0 0.3 1.4 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 ADV25263.1 - 0.056 13.8 0.2 0.1 13.0 0.2 1.3 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) RED_N PF07808.13 ADV25263.1 - 0.099 12.2 2.8 0.072 12.7 1.0 1.6 2 0 0 2 2 2 0 RED-like protein N-terminal region zf-met PF12874.7 ADV25263.1 - 0.21 12.0 0.1 0.43 11.0 0.1 1.5 1 0 0 1 1 1 0 Zinc-finger of C2H2 type Arf PF00025.21 ADV25264.1 - 1.9e-38 131.7 0.0 7.5e-37 126.5 0.0 2.1 2 0 0 2 2 2 1 ADP-ribosylation factor family G-alpha PF00503.20 ADV25264.1 - 1.5e-13 50.6 0.0 4.5e-09 35.9 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.13 ADV25264.1 - 6.2e-10 39.3 0.0 1.2e-09 38.4 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 ADV25264.1 - 8.5e-09 35.2 0.0 2.9e-08 33.5 0.0 1.9 1 1 0 1 1 1 1 Ras family SRPRB PF09439.10 ADV25264.1 - 2.3e-08 33.7 0.0 3.3e-08 33.2 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 ADV25264.1 - 9.3e-08 32.2 0.0 1.4e-07 31.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ADV25264.1 - 2.6e-05 23.7 0.0 3e-05 23.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 ADV25264.1 - 5.9e-05 22.7 0.0 0.0018 17.8 0.0 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain TniB PF05621.11 ADV25264.1 - 0.012 15.1 0.0 0.021 14.3 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein FeoB_N PF02421.18 ADV25264.1 - 0.016 14.7 0.1 0.041 13.4 0.1 1.7 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_22 PF13401.6 ADV25264.1 - 0.02 15.2 0.0 0.049 13.9 0.0 1.7 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 ADV25264.1 - 0.024 15.1 0.1 0.033 14.7 0.1 1.4 1 1 0 1 1 1 0 ABC transporter AAA_15 PF13175.6 ADV25264.1 - 0.17 11.6 0.0 0.33 10.6 0.0 1.3 1 1 0 1 1 1 0 AAA ATPase domain 7tm_1 PF00001.21 ADV25265.1 - 4e-14 52.6 0.2 5.5e-14 52.1 0.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Git3 PF11710.8 ADV25265.1 - 2.2e-09 37.4 7.8 3.8e-09 36.6 7.8 1.3 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 GPR_Gpa2_C PF11970.8 ADV25265.1 - 0.052 13.6 0.7 0.12 12.4 0.7 1.6 1 0 0 1 1 1 0 G protein-coupled glucose receptor regulating Gpa2 C-term 7tm_2 PF00002.24 ADV25265.1 - 0.053 12.8 4.5 0.099 11.9 4.5 1.4 1 0 0 1 1 1 0 7 transmembrane receptor (Secretin family) START PF01852.19 ADV25266.1 - 7e-20 71.3 0.6 1.7e-14 53.7 0.0 2.5 2 0 0 2 2 2 2 START domain WW PF00397.26 ADV25267.1 - 1.1e-07 31.8 8.1 2.3e-07 30.8 8.1 1.6 1 0 0 1 1 1 1 WW domain DUF4611 PF15387.6 ADV25267.1 - 2 8.7 7.0 1.2 9.4 1.5 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) EF-hand_6 PF13405.6 ADV25268.1 - 2.1e-07 30.3 3.8 0.0017 18.1 0.2 3.1 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 ADV25268.1 - 2.5e-07 31.0 0.3 7.6e-07 29.5 0.3 1.9 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 ADV25268.1 - 2.6e-06 26.6 0.1 1.7e-05 24.0 0.0 2.4 2 0 0 2 2 2 1 EF hand EF-hand_1 PF00036.32 ADV25268.1 - 8.1e-06 25.0 2.5 0.0005 19.4 0.0 3.0 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 ADV25268.1 - 0.012 15.4 0.1 0.25 11.2 0.0 2.6 2 0 0 2 2 2 0 EF-hand domain pair Aldolase_II PF00596.21 ADV25269.1 - 1.9e-44 151.8 0.0 3.5e-44 151.0 0.0 1.4 2 0 0 2 2 2 1 Class II Aldolase and Adducin N-terminal domain Glyco_transf_21 PF13506.6 ADV25270.1 - 2.2e-22 79.4 0.0 9.4e-10 38.2 0.0 3.1 2 1 0 2 2 2 2 Glycosyl transferase family 21 Glyco_tranf_2_3 PF13641.6 ADV25270.1 - 2.7e-16 60.2 0.0 8.2e-16 58.6 0.0 1.7 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 ADV25270.1 - 3.5e-07 30.2 0.0 5.7e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 bZIP_1 PF00170.21 ADV25271.1 - 0.11 12.6 2.5 0.35 11.0 2.5 1.9 1 1 0 1 1 1 0 bZIP transcription factor Chitin_synth_2 PF03142.15 ADV25272.1 - 3e-277 920.4 0.1 3.9e-277 920.0 0.1 1.1 1 0 0 1 1 1 1 Chitin synthase Glyco_trans_2_3 PF13632.6 ADV25272.1 - 7.1e-13 48.9 0.5 2.5e-12 47.1 0.5 2.0 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 ADV25272.1 - 2.6e-10 40.6 0.0 7.9e-10 39.0 0.0 1.9 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 ADV25272.1 - 0.00059 19.4 0.0 0.17 11.3 0.0 2.7 2 0 0 2 2 2 2 Glycosyl transferase family 21 NDUF_B4 PF07225.12 ADV25274.1 - 0.00049 20.0 0.0 0.00053 19.9 0.0 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4) Spo12 PF05032.12 ADV25275.1 - 2.5e-07 30.5 0.4 2.5e-07 30.5 0.4 1.9 2 0 0 2 2 2 1 Spo12 family GPI2 PF06432.11 ADV25276.1 - 1.8e-63 214.7 0.0 2e-63 214.5 0.0 1.0 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase Complex1_LYR PF05347.15 ADV25277.1 - 4.4e-10 39.5 0.3 1e-09 38.3 0.3 1.6 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 ADV25277.1 - 0.01 16.5 1.3 0.01 16.5 1.3 1.6 2 0 0 2 2 2 0 Complex1_LYR-like ubiquitin PF00240.23 ADV25278.1 - 5.2e-14 51.8 0.0 9.1e-14 51.0 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ADV25278.1 - 9.6e-06 25.3 0.0 1.4e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 ADV25278.1 - 0.025 15.1 0.0 0.041 14.4 0.0 1.5 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.6 ADV25278.1 - 0.073 13.2 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Maf PF02545.14 ADV25279.1 - 2.1e-32 112.2 0.0 2.7e-32 111.9 0.0 1.1 1 0 0 1 1 1 1 Maf-like protein STAS PF01740.21 ADV25279.1 - 0.16 11.6 0.0 0.29 10.8 0.0 1.4 1 0 0 1 1 1 0 STAS domain BCNT PF07572.12 ADV25280.1 - 2e-18 66.2 1.8 4.9e-18 65.0 1.8 1.7 1 0 0 1 1 1 1 Bucentaur or craniofacial development SR-25 PF10500.9 ADV25280.1 - 0.004 16.8 15.6 0.004 16.8 15.6 2.2 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein Hist_deacetyl PF00850.19 ADV25281.1 - 1.6e-81 274.1 0.0 2e-81 273.9 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain Glyco_hydro_67C PF07477.12 ADV25281.1 - 0.25 10.8 1.2 0.45 10.0 1.2 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 67 C-terminus adh_short PF00106.25 ADV25282.1 - 1.4e-36 125.8 0.0 2e-36 125.3 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ADV25282.1 - 3.2e-23 82.5 0.0 4.6e-23 82.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ADV25282.1 - 2.6e-12 47.0 1.8 1.6e-11 44.4 1.8 1.9 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 ADV25282.1 - 0.0009 18.8 0.1 0.0013 18.3 0.1 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family SRP-alpha_N PF04086.13 ADV25283.1 - 1.9 8.4 9.3 3.8 7.4 9.3 1.5 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Pkinase PF00069.25 ADV25284.1 - 4.1e-69 232.9 0.0 7.7e-69 232.0 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV25284.1 - 5.1e-37 127.5 0.0 9.3e-37 126.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.19 ADV25284.1 - 1.2e-09 37.8 0.1 2.4e-09 36.9 0.1 1.5 1 0 0 1 1 1 1 Kinase associated domain 1 Kinase-like PF14531.6 ADV25284.1 - 1.2e-05 24.8 0.0 2.2e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 ADV25284.1 - 0.0034 17.0 0.0 0.0076 15.9 0.0 1.5 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 ADV25284.1 - 0.013 15.4 0.0 0.029 14.3 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ADV25284.1 - 0.02 13.8 0.1 0.036 13.0 0.1 1.3 1 0 0 1 1 1 0 Haspin like kinase domain EcsC PF12787.7 ADV25284.1 - 0.083 12.5 0.1 0.16 11.7 0.1 1.4 1 0 0 1 1 1 0 EcsC protein family Pkinase_fungal PF17667.1 ADV25284.1 - 9.7 4.8 9.0 1.1 7.9 0.0 3.1 3 0 0 3 3 3 0 Fungal protein kinase Ribosomal_L7Ae PF01248.26 ADV25286.1 - 1.2e-21 76.2 0.4 2.3e-21 75.4 0.4 1.5 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family CLPTM1 PF05602.12 ADV25286.1 - 0.0042 16.2 0.2 0.0053 15.8 0.2 1.1 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) DUF3440 PF11922.8 ADV25286.1 - 0.065 12.9 0.0 0.13 12.0 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3440) Cyt-b5 PF00173.28 ADV25287.1 - 4.1e-24 84.5 0.0 5.4e-24 84.1 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain SNF2_N PF00176.23 ADV25288.1 - 1.5e-75 254.1 0.0 3e-75 253.1 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.10 ADV25288.1 - 6e-37 126.2 1.0 6e-37 126.2 1.0 3.0 3 0 0 3 3 3 1 SLIDE HAND PF09110.11 ADV25288.1 - 3.6e-34 117.9 2.3 3.6e-34 117.9 2.3 4.0 4 0 0 4 4 4 1 HAND Helicase_C PF00271.31 ADV25288.1 - 2e-19 70.0 0.0 4.5e-18 65.6 0.0 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ADV25288.1 - 2.5e-09 37.3 0.1 1.2e-07 31.9 0.0 3.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF1086 PF06461.11 ADV25288.1 - 2.1e-05 24.4 0.2 5.8e-05 23.0 0.2 1.7 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1086) DBINO PF13892.6 ADV25288.1 - 5.6e-05 23.5 3.4 5.6e-05 23.5 3.4 4.1 4 0 0 4 4 4 1 DNA-binding domain HDA2-3 PF11496.8 ADV25288.1 - 0.0002 20.6 0.0 0.001 18.3 0.0 2.2 2 1 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 DEAD PF00270.29 ADV25288.1 - 0.00032 20.5 0.0 0.0012 18.7 0.0 2.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase DEAD_2 PF06733.15 ADV25288.1 - 0.013 15.1 0.0 0.032 13.9 0.0 1.6 1 0 0 1 1 1 0 DEAD_2 AAA_14 PF13173.6 ADV25288.1 - 0.013 15.5 1.1 0.044 13.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain GCP_N_terminal PF17681.1 ADV25289.1 - 1e-28 100.9 0.0 3.2e-28 99.3 0.0 1.8 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 ADV25289.1 - 9.8e-05 22.0 0.1 0.00035 20.1 0.0 1.9 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal HIT PF01230.23 ADV25291.1 - 7.9e-18 65.0 0.1 1.4e-17 64.2 0.1 1.4 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 ADV25291.1 - 2e-06 28.3 0.0 3.2e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding GalP_UDP_tr_C PF02744.17 ADV25291.1 - 0.018 14.7 0.0 0.028 14.2 0.0 1.2 1 0 0 1 1 1 0 Galactose-1-phosphate uridyl transferase, C-terminal domain Mob1_phocein PF03637.17 ADV25292.1 - 2.9e-75 252.0 0.1 3.5e-75 251.7 0.1 1.0 1 0 0 1 1 1 1 Mob1/phocein family Amidohydro_1 PF01979.20 ADV25293.1 - 1.1e-63 215.6 1.4 2e-63 214.8 1.4 1.3 1 0 0 1 1 1 1 Amidohydrolase family Urease_alpha PF00449.20 ADV25293.1 - 1.7e-55 186.5 4.0 4.1e-55 185.3 4.0 1.7 1 0 0 1 1 1 1 Urease alpha-subunit, N-terminal domain Urease_gamma PF00547.18 ADV25293.1 - 4e-39 132.9 0.0 1e-38 131.6 0.0 1.7 1 0 0 1 1 1 1 Urease, gamma subunit Urease_beta PF00699.20 ADV25293.1 - 3.6e-37 126.3 0.0 6.5e-37 125.5 0.0 1.4 1 0 0 1 1 1 1 Urease beta subunit Amidohydro_3 PF07969.11 ADV25293.1 - 1.3e-05 24.9 2.3 2.3e-05 24.1 0.3 1.9 1 1 0 2 2 2 1 Amidohydrolase family zf-C3HC4_2 PF13923.6 ADV25294.1 - 7.1e-10 38.6 14.6 1.5e-09 37.5 10.5 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ADV25294.1 - 9.5e-10 38.3 9.3 9.5e-10 38.3 9.3 2.5 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 ADV25294.1 - 1.3e-08 34.5 15.6 1.3e-08 34.5 11.3 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ADV25294.1 - 1e-07 31.7 12.0 4.3e-07 29.7 8.4 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) SAP PF02037.27 ADV25294.1 - 1.5e-07 31.0 0.0 5.7e-07 29.1 0.0 2.1 1 0 0 1 1 1 1 SAP domain zf-C3HC4_4 PF15227.6 ADV25294.1 - 2.6e-07 30.7 10.9 2.6e-07 30.7 10.9 2.5 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 ADV25294.1 - 3.1e-06 27.4 16.6 3.4e-06 27.3 10.8 2.3 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.6 ADV25294.1 - 6.6e-06 26.0 14.6 1.1e-05 25.3 10.3 2.2 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_6 PF14835.6 ADV25294.1 - 6.2e-05 22.8 3.5 6.2e-05 22.8 3.5 1.7 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-RING_10 PF16685.5 ADV25294.1 - 0.00015 21.8 4.1 0.00029 20.9 4.1 1.4 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-rbx1 PF12678.7 ADV25294.1 - 0.00019 21.7 8.6 0.00019 21.7 8.6 2.5 2 1 0 2 2 2 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 ADV25294.1 - 0.009 15.9 14.8 0.015 15.1 10.2 2.3 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 Arteri_nucleo PF01481.16 ADV25294.1 - 0.023 15.0 0.0 0.062 13.6 0.0 1.7 1 0 0 1 1 1 0 Arterivirus nucleocapsid protein zf-RING_4 PF14570.6 ADV25294.1 - 0.033 14.0 2.5 0.033 14.0 2.5 3.0 3 0 0 3 3 3 0 RING/Ubox like zinc-binding domain zinc-ribbons_6 PF07191.12 ADV25294.1 - 0.82 9.7 9.9 0.18 11.8 5.2 2.1 2 0 0 2 2 2 0 zinc-ribbons zf-ANAPC11 PF12861.7 ADV25294.1 - 1 9.5 6.2 0.27 11.3 2.8 1.8 2 0 0 2 2 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-P11 PF03854.14 ADV25294.1 - 2.3 8.0 13.2 2.1 8.1 3.4 3.2 2 1 1 3 3 3 0 P-11 zinc finger DZR PF12773.7 ADV25294.1 - 4.7 7.3 12.6 3.3 7.8 8.4 2.5 2 1 0 2 2 2 0 Double zinc ribbon Forkhead PF00250.18 ADV25295.1 - 3.7e-24 84.8 0.0 6.8e-24 84.0 0.0 1.5 1 0 0 1 1 1 1 Forkhead domain FHA PF00498.26 ADV25295.1 - 1.3e-07 31.8 0.0 2.7e-07 30.8 0.0 1.5 1 0 0 1 1 1 1 FHA domain CUE PF02845.16 ADV25296.1 - 3.1e-06 26.8 0.0 4.7e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 CUE domain Cue1_U7BR PF18499.1 ADV25296.1 - 0.005 16.9 4.2 0.0082 16.2 4.2 1.3 1 0 0 1 1 1 1 Ubc7p-binding region of Cue1 G2BR PF18442.1 ADV25296.1 - 0.059 13.0 3.8 0.097 12.3 3.8 1.3 1 0 0 1 1 1 0 E3 gp78 Ube2g2-binding region (G2BR) Coleoptericin PF06286.11 ADV25296.1 - 0.066 13.3 0.2 0.1 12.7 0.2 1.3 1 0 0 1 1 1 0 Coleoptericin YqeY PF09424.10 ADV25297.1 - 1.5e-18 67.2 0.0 1.8e-18 67.0 0.0 1.0 1 0 0 1 1 1 1 Yqey-like protein PAPA-1 PF04795.12 ADV25299.1 - 7.4e-15 55.5 3.8 7.4e-15 55.5 3.8 2.7 3 1 0 3 3 3 1 PAPA-1-like conserved region CAF1A PF12253.8 ADV25299.1 - 4.1 7.7 12.2 0.38 11.0 3.5 2.7 2 0 0 2 2 2 0 Chromatin assembly factor 1 subunit A Cyclin PF08613.11 ADV25300.1 - 7.2e-41 140.2 0.0 7.2e-41 140.2 0.0 2.4 3 0 0 3 3 3 1 Cyclin zf-CCCH PF00642.24 ADV25301.1 - 4e-21 74.4 40.8 2.1e-07 30.7 2.2 5.7 5 1 0 5 5 5 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 ADV25301.1 - 3.7e-13 50.1 21.4 3.7e-06 27.6 0.5 5.3 3 1 2 5 5 5 3 Torus domain zf_CCCH_4 PF18345.1 ADV25301.1 - 6.7e-11 41.9 46.4 4.3e-05 23.4 2.3 5.9 6 0 0 6 6 6 4 Zinc finger domain zf-CCCH_4 PF18044.1 ADV25301.1 - 3e-09 36.5 44.2 0.00045 20.0 2.8 5.8 6 0 0 6 6 6 4 CCCH-type zinc finger zf-CCCH_2 PF14608.6 ADV25301.1 - 4.1e-05 23.9 48.6 0.11 13.0 2.7 5.5 5 1 0 5 5 5 4 RNA-binding, Nab2-type zinc finger zf-CCCH_3 PF15663.5 ADV25301.1 - 0.0016 18.6 11.0 0.07 13.3 1.3 4.5 4 1 0 4 4 4 2 Zinc-finger containing family LysM PF01476.20 ADV25302.1 - 3.4e-14 52.6 0.0 2.7e-06 27.3 0.0 2.2 2 0 0 2 2 2 2 LysM domain HTH_28 PF13518.6 ADV25302.1 - 0.13 12.4 0.0 13 6.0 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain Aldo_ket_red PF00248.21 ADV25303.1 - 6.1e-36 124.1 0.2 1.2e-31 110.0 0.0 2.0 2 0 0 2 2 2 2 Aldo/keto reductase family OSTbeta PF15048.6 ADV25304.1 - 0.00017 21.7 0.4 0.0005 20.2 0.1 1.8 2 0 0 2 2 2 1 Organic solute transporter subunit beta protein Herpes_gE PF02480.16 ADV25304.1 - 0.012 14.5 0.1 0.019 13.8 0.1 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E TMEM154 PF15102.6 ADV25304.1 - 0.015 15.2 0.1 0.015 15.2 0.1 2.1 2 0 0 2 2 2 0 TMEM154 protein family EphA2_TM PF14575.6 ADV25304.1 - 0.023 15.6 0.4 0.071 14.0 0.1 1.9 2 0 0 2 2 1 0 Ephrin type-A receptor 2 transmembrane domain RIFIN PF02009.16 ADV25304.1 - 0.038 13.9 0.0 0.068 13.1 0.0 1.4 1 0 0 1 1 1 0 Rifin Peptidase_S49_N PF08496.10 ADV25304.1 - 0.046 13.8 2.0 0.93 9.5 3.6 2.1 2 0 0 2 2 2 0 Peptidase family S49 N-terminal YqgC PF17430.2 ADV25304.1 - 0.055 13.6 0.3 0.22 11.6 0.3 2.1 1 0 0 1 1 1 0 Uncharacterized YqgC-like Adeno_E3_CR2 PF02439.15 ADV25304.1 - 0.12 12.1 3.1 0.26 11.1 3.1 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 DUF4381 PF14316.6 ADV25304.1 - 0.13 12.5 0.1 0.24 11.6 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Vpu PF00558.19 ADV25304.1 - 0.14 12.0 0.2 0.3 10.9 0.2 1.5 1 0 0 1 1 1 0 Vpu protein Cyt_bd_oxida_I PF01654.17 ADV25304.1 - 0.22 10.1 0.0 0.32 9.6 0.0 1.1 1 0 0 1 1 1 0 Cytochrome bd terminal oxidase subunit I Plasmodium_Vir PF05795.11 ADV25304.1 - 4.1 6.7 4.5 1 8.7 0.3 2.0 1 1 1 2 2 2 0 Plasmodium vivax Vir protein RTC4 PF14474.6 ADV25305.1 - 5e-11 42.8 0.0 1.7e-10 41.1 0.0 2.0 1 0 0 1 1 1 1 RTC4-like domain DUF1924 PF09086.11 ADV25305.1 - 0.11 12.9 0.8 0.5 10.8 0.8 2.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1924) Colicin_E5 PF12106.8 ADV25305.1 - 3.1 8.2 10.3 2.7 8.4 0.6 4.3 4 0 0 4 4 4 0 Colicin E5 ribonuclease domain MFS_1 PF07690.16 ADV25306.1 - 1.7e-11 43.7 17.2 2.8e-06 26.5 1.1 3.5 4 0 0 4 4 4 3 Major Facilitator Superfamily MFS_2 PF13347.6 ADV25306.1 - 0.00049 18.8 3.9 0.00049 18.8 3.9 3.5 3 1 0 3 3 3 1 MFS/sugar transport protein MFS_1_like PF12832.7 ADV25306.1 - 0.011 14.6 1.3 0.027 13.3 0.0 1.9 1 1 0 2 2 2 0 MFS_1 like family Shugoshin_C PF07557.11 ADV25307.1 - 1.9e-08 33.9 4.5 1.6e-07 31.0 4.5 2.8 1 0 0 1 1 1 1 Shugoshin C terminus Spc29 PF17082.5 ADV25307.1 - 0.0016 18.3 0.6 0.0052 16.7 0.6 1.9 1 0 0 1 1 1 1 Spindle Pole Component 29 ZapB PF06005.12 ADV25307.1 - 0.008 16.6 0.9 0.019 15.4 0.9 1.6 1 0 0 1 1 1 1 Cell division protein ZapB ATG16 PF08614.11 ADV25307.1 - 0.019 15.2 1.6 0.019 15.2 1.6 2.7 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) DUF4094 PF13334.6 ADV25307.1 - 0.044 14.2 1.1 0.22 12.0 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4094) DivIC PF04977.15 ADV25307.1 - 0.082 12.7 1.9 0.19 11.5 1.9 1.5 1 0 0 1 1 1 0 Septum formation initiator Enkurin PF13864.6 ADV25307.1 - 0.44 11.0 3.4 1.1 9.7 3.4 1.7 1 0 0 1 1 1 0 Calmodulin-binding Cnn_1N PF07989.11 ADV25307.1 - 0.45 10.7 5.3 0.6 10.3 2.5 2.4 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 NTF2 PF02136.20 ADV25308.1 - 9e-37 126.3 0.8 1e-36 126.2 0.8 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain DUF4440 PF14534.6 ADV25308.1 - 0.026 14.9 0.0 0.031 14.7 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) DUF4518 PF15008.6 ADV25308.1 - 0.1 11.7 0.3 0.14 11.3 0.3 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4518) Peptidase_C2 PF00648.21 ADV25310.1 - 4.8e-13 48.8 0.0 7.7e-13 48.1 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.22 ADV25310.1 - 2.7e-09 37.4 0.0 1.4 9.1 0.0 5.1 4 1 0 4 4 4 4 Calpain large subunit, domain III MIT PF04212.18 ADV25310.1 - 0.024 14.7 0.0 0.07 13.2 0.0 1.8 1 0 0 1 1 1 0 MIT (microtubule interacting and transport) domain Aldedh PF00171.22 ADV25311.1 - 2e-99 333.2 0.0 2.5e-99 332.9 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF2315 PF10231.9 ADV25312.1 - 2.7e-20 72.7 0.1 3.7e-20 72.3 0.1 1.2 1 0 0 1 1 1 1 Apoptogenic protein 1 PIF1 PF05970.14 ADV25313.1 - 3.5e-50 171.2 0.0 1.1e-40 139.9 0.0 3.1 2 1 0 2 2 2 2 PIF1-like helicase AAA_30 PF13604.6 ADV25313.1 - 1.3e-21 77.2 0.0 3.3e-21 75.9 0.0 1.7 2 0 0 2 2 2 1 AAA domain Cauli_VI PF01693.16 ADV25313.1 - 7.5e-18 64.6 0.2 1.7e-17 63.5 0.2 1.6 1 0 0 1 1 1 1 Caulimovirus viroplasmin AAA_19 PF13245.6 ADV25313.1 - 1.3e-10 41.8 0.0 3.3e-10 40.5 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 ADV25313.1 - 1.2e-05 25.6 0.0 3.5e-05 24.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain Herpes_Helicase PF02689.14 ADV25313.1 - 0.0002 19.5 0.1 0.00075 17.6 0.0 1.8 2 0 0 2 2 2 1 Helicase UvrD_C_2 PF13538.6 ADV25313.1 - 0.0013 18.5 0.3 0.006 16.4 0.1 2.2 2 1 0 2 2 2 1 UvrD-like helicase C-terminal domain AAA_16 PF13191.6 ADV25313.1 - 0.0033 17.8 0.0 0.01 16.2 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain T2SSE PF00437.20 ADV25313.1 - 0.0067 15.5 0.0 0.012 14.7 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein ABC_tran PF00005.27 ADV25313.1 - 0.0082 16.7 0.0 0.021 15.4 0.0 1.7 1 0 0 1 1 1 1 ABC transporter PhoH PF02562.16 ADV25313.1 - 0.011 15.2 0.0 0.024 14.1 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein AAA_29 PF13555.6 ADV25313.1 - 0.012 15.3 0.0 0.043 13.6 0.0 1.9 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_7 PF12775.7 ADV25313.1 - 0.019 14.5 0.0 0.038 13.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF2075 PF09848.9 ADV25313.1 - 0.024 13.9 0.0 0.041 13.1 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) DUF5605 PF18310.1 ADV25313.1 - 0.028 14.3 0.0 0.061 13.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5605) DUF815 PF05673.13 ADV25313.1 - 0.048 12.8 0.0 0.097 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) NACHT PF05729.12 ADV25313.1 - 0.06 13.3 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_11 PF13086.6 ADV25313.1 - 0.091 12.5 0.1 7.3 6.3 0.0 2.5 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 ADV25313.1 - 0.11 12.3 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase CCDC158 PF15921.5 ADV25314.1 - 0.009 13.9 0.2 0.011 13.6 0.2 1.1 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 158 DUF4342 PF14242.6 ADV25314.1 - 8.1 6.5 10.5 0.32 11.0 2.3 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4342) SNF2_N PF00176.23 ADV25315.1 - 1.7e-52 178.3 0.0 2.7e-52 177.7 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ADV25315.1 - 2.2e-19 69.8 0.1 2.2e-17 63.4 0.1 2.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ADV25315.1 - 7.3e-09 35.8 0.2 8.8e-08 32.3 0.0 2.7 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 ADV25315.1 - 0.00049 19.4 1.3 0.00073 18.8 0.0 1.8 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase CUE PF02845.16 ADV25315.1 - 0.0031 17.2 0.0 0.0076 15.9 0.0 1.7 1 0 0 1 1 1 1 CUE domain DMA PF03474.14 ADV25315.1 - 0.043 13.4 0.0 0.14 11.8 0.0 1.9 2 0 0 2 2 2 0 DMRTA motif AAA_34 PF13872.6 ADV25315.1 - 0.092 11.6 0.0 0.19 10.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing NTP hydrolase pore-1 Nucleo_P87 PF07267.11 ADV25315.1 - 0.68 8.7 12.1 0.68 8.7 10.5 1.7 1 1 1 2 2 2 0 Nucleopolyhedrovirus capsid protein P87 PALP PF00291.25 ADV25316.1 - 9.1e-59 199.3 0.0 2.7e-58 197.7 0.0 1.6 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Dopey_N PF04118.14 ADV25317.1 - 4e-104 348.0 2.0 1.5e-103 346.1 0.0 2.7 3 0 0 3 3 3 1 Dopey, N-terminal DUF3361 PF11841.8 ADV25317.1 - 6.4 6.7 6.5 14 5.6 0.2 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF3361) Syntaxin PF00804.25 ADV25318.1 - 1.2e-27 96.9 15.8 4.4e-27 95.1 15.8 1.8 1 1 0 1 1 1 1 Syntaxin SNARE PF05739.19 ADV25318.1 - 9.2e-09 35.2 1.1 1.9e-08 34.2 1.1 1.6 1 0 0 1 1 1 1 SNARE domain Syntaxin_2 PF14523.6 ADV25318.1 - 0.00071 19.9 13.3 0.00081 19.7 7.5 2.4 2 0 0 2 2 2 1 Syntaxin-like protein DUF2207 PF09972.9 ADV25318.1 - 0.14 10.9 1.0 0.18 10.5 0.2 1.6 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) DUF5345 PF17280.2 ADV25318.1 - 0.15 12.0 0.3 0.15 12.0 0.3 2.2 2 1 1 3 3 3 0 Family of unknown function (DUF5345) TB2_DP1_HVA22 PF03134.19 ADV25318.1 - 0.16 11.9 0.1 0.33 10.9 0.1 1.4 1 0 0 1 1 1 0 TB2/DP1, HVA22 family Pox_EPC_I2-L1 PF12575.8 ADV25318.1 - 0.2 11.9 0.1 0.43 10.8 0.1 1.5 1 0 0 1 1 1 0 Poxvirus entry protein complex L1 and I2 TAFH PF07531.14 ADV25318.1 - 0.27 11.4 3.6 0.15 12.2 0.6 2.1 2 0 0 2 2 2 0 NHR1 homology to TAF V-SNARE PF05008.15 ADV25318.1 - 1.7 9.0 12.4 0.23 11.9 2.0 3.3 2 2 1 3 3 3 0 Vesicle transport v-SNARE protein N-terminus Sulfatase_C PF14707.6 ADV25318.1 - 2.4 8.9 6.6 14 6.4 0.4 2.8 3 0 0 3 3 3 0 C-terminal region of aryl-sulfatase PCRF PF03462.18 ADV25318.1 - 5.5 6.8 13.1 1.1 9.0 2.4 2.5 1 1 0 2 2 2 0 PCRF domain Mod_r PF07200.13 ADV25318.1 - 8 6.6 18.2 0.29 11.3 4.6 2.9 1 1 2 3 3 3 0 Modifier of rudimentary (Mod(r)) protein ABC_tran PF00005.27 ADV25319.1 - 1.6e-34 119.3 0.0 3.2e-34 118.4 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 ADV25319.1 - 5e-30 105.1 8.8 7.4e-30 104.5 8.8 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 ADV25319.1 - 4.7e-06 26.2 0.1 0.0002 20.9 0.1 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 ADV25319.1 - 0.00026 20.8 0.1 0.0005 19.9 0.1 1.5 1 0 0 1 1 1 1 AAA ATPase domain DEAD PF00270.29 ADV25319.1 - 0.00026 20.8 0.0 0.00048 19.9 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 ADV25319.1 - 0.00049 20.4 0.1 0.0039 17.5 0.1 2.2 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ADV25319.1 - 0.00086 19.7 0.1 0.0029 18.0 0.1 1.9 1 0 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 ADV25319.1 - 0.002 18.0 0.0 0.004 17.1 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 ADV25319.1 - 0.005 16.5 0.2 0.012 15.3 0.2 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.6 ADV25319.1 - 0.014 15.2 0.0 0.043 13.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system DUF87 PF01935.17 ADV25319.1 - 0.03 14.4 0.0 0.099 12.7 0.0 1.8 1 0 0 1 1 1 0 Helicase HerA, central domain AAA_5 PF07728.14 ADV25319.1 - 0.038 14.0 0.0 2.8 7.9 0.0 3.0 2 1 1 3 3 3 0 AAA domain (dynein-related subfamily) MMR_HSR1 PF01926.23 ADV25319.1 - 0.039 14.0 0.0 0.082 13.0 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_23 PF13476.6 ADV25319.1 - 0.053 14.0 0.9 0.12 12.8 0.1 2.0 2 0 0 2 2 2 0 AAA domain Wzy_C PF04932.15 ADV25319.1 - 0.055 13.1 0.3 11 5.6 0.2 2.9 2 1 0 2 2 2 0 O-Antigen ligase G-alpha PF00503.20 ADV25319.1 - 0.12 11.6 0.0 0.19 10.8 0.0 1.4 1 0 0 1 1 1 0 G-protein alpha subunit REV PF00424.18 ADV25319.1 - 7.8 6.6 6.9 1.5 8.8 2.1 2.3 2 0 0 2 2 2 0 REV protein (anti-repression trans-activator protein) CLPTM1 PF05602.12 ADV25320.1 - 3.2e-136 454.8 0.0 3.8e-136 454.5 0.0 1.0 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) PQ-loop PF04193.14 ADV25320.1 - 9.3e-05 22.1 1.3 0.00033 20.4 0.3 2.2 2 0 0 2 2 2 1 PQ loop repeat 2TM PF13239.6 ADV25320.1 - 0.14 12.5 0.2 0.14 12.5 0.2 2.6 1 1 2 3 3 3 0 2TM domain Rnf-Nqr PF02508.14 ADV25320.1 - 0.41 10.6 3.1 0.45 10.5 0.1 2.2 2 0 0 2 2 2 0 Rnf-Nqr subunit, membrane protein SIP1 PF04938.12 ADV25321.1 - 1.2e-11 44.7 0.0 3.8e-11 43.1 0.0 1.7 1 1 0 1 1 1 1 Survival motor neuron (SMN) interacting protein 1 (SIP1) Glyco_trans_2_3 PF13632.6 ADV25321.1 - 0.15 11.9 0.1 0.24 11.3 0.1 1.2 1 0 0 1 1 1 0 Glycosyl transferase family group 2 DUF4035 PF13227.6 ADV25322.1 - 0.027 14.2 0.0 0.17 11.6 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4035) DEAD PF00270.29 ADV25323.1 - 7e-35 120.4 0.0 1.1e-33 116.4 0.0 2.2 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ADV25323.1 - 1.3e-22 80.3 0.0 3.5e-22 78.8 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 ADV25323.1 - 4.1e-16 58.9 0.2 8.4e-16 58.0 0.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 ADV25323.1 - 3.1e-05 24.0 0.3 0.00055 20.0 0.0 2.6 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit CPSF73-100_C PF11718.8 ADV25324.1 - 6.6e-61 205.6 0.0 1.1e-60 204.8 0.0 1.4 1 0 0 1 1 1 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Beta-Casp PF10996.8 ADV25324.1 - 8.6e-26 90.4 0.0 1.9e-25 89.3 0.0 1.6 1 0 0 1 1 1 1 Beta-Casp domain Lactamase_B_6 PF16661.5 ADV25324.1 - 8.2e-20 71.0 0.3 1.1e-18 67.4 0.1 2.5 2 1 1 3 3 3 1 Metallo-beta-lactamase superfamily domain Lactamase_B PF00753.27 ADV25324.1 - 9.4e-20 71.5 0.6 1.8e-19 70.5 0.6 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily RMMBL PF07521.12 ADV25324.1 - 6e-14 51.7 0.1 1.1e-13 50.9 0.1 1.4 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_2 PF12706.7 ADV25324.1 - 4.9e-07 29.5 1.0 1.8e-06 27.6 0.2 2.2 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 ADV25324.1 - 1.1e-06 28.6 0.1 7.2e-06 26.0 0.1 2.3 1 1 0 1 1 1 1 Beta-lactamase superfamily domain B56 PF01603.20 ADV25325.1 - 9.1e-194 644.2 4.8 1.1e-193 643.9 4.8 1.0 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) PIN_4 PF13638.6 ADV25326.1 - 5.4e-05 23.5 0.0 0.0001 22.6 0.0 1.5 1 0 0 1 1 1 1 PIN domain Spo12 PF05032.12 ADV25327.1 - 1.6e-12 47.1 0.7 1.6e-12 47.1 0.7 2.5 1 1 1 2 2 2 1 Spo12 family DUF2057 PF09829.9 ADV25328.1 - 0.063 13.4 6.6 0.07 13.3 6.6 1.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2057) DUF4680 PF15730.5 ADV25328.1 - 0.19 12.1 4.4 0.21 11.9 4.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4680) DSPc PF00782.20 ADV25329.1 - 4.6e-36 123.6 0.1 1.7e-24 86.1 0.0 2.7 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ADV25329.1 - 6.1e-05 22.7 0.1 0.12 11.9 0.0 2.5 2 0 0 2 2 2 2 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.12 ADV25329.1 - 0.0031 17.8 0.0 1.6 9.1 0.0 2.6 2 0 0 2 2 2 2 Rit1 DUSP-like domain SVIP PF15811.5 ADV25329.1 - 0.012 16.1 3.0 0.058 13.8 3.0 2.2 1 0 0 1 1 1 0 Small VCP/p97-interacting protein Nramp PF01566.18 ADV25330.1 - 1.5e-81 274.2 34.0 4.3e-46 157.5 16.2 2.4 3 0 0 3 3 3 2 Natural resistance-associated macrophage protein PCI PF01399.27 ADV25331.1 - 2e-05 25.1 0.0 4.6e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 PCI domain TPR_8 PF13181.6 ADV25331.1 - 0.025 14.8 0.1 0.24 11.7 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat MHYT PF03707.16 ADV25332.1 - 3.3e-11 43.2 25.9 7.7e-06 26.0 5.0 4.8 4 0 0 4 4 4 3 Bacterial signalling protein N terminal repeat Peptidase_M28 PF04389.17 ADV25333.1 - 2.7e-35 121.9 0.0 3.9e-35 121.3 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 Malate_synthase PF01274.22 ADV25334.1 - 4e-205 682.1 0.0 5.1e-205 681.7 0.0 1.0 1 0 0 1 1 1 1 Malate synthase HpcH_HpaI PF03328.14 ADV25334.1 - 0.049 12.8 0.0 0.13 11.4 0.0 1.7 2 0 0 2 2 2 0 HpcH/HpaI aldolase/citrate lyase family SUR7 PF06687.12 ADV25335.1 - 6.5e-17 61.9 20.1 9.4e-17 61.4 20.1 1.2 1 0 0 1 1 1 1 SUR7/PalI family TMEM52 PF14979.6 ADV25335.1 - 0.04 13.8 0.3 0.04 13.8 0.3 1.8 2 1 0 2 2 2 0 Transmembrane 52 TMEM100 PF16311.5 ADV25335.1 - 2.6 7.6 9.9 0.41 10.2 1.0 2.9 3 0 0 3 3 3 0 Transmembrane protein 100 DUF805 PF05656.14 ADV25335.1 - 8.5 6.8 8.6 1.9 8.9 4.5 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF805) VIT1 PF01988.19 ADV25335.1 - 9.8 6.0 10.2 0.67 9.8 5.6 1.5 2 0 0 2 2 2 0 VIT family ADH_N PF08240.12 ADV25337.1 - 4.8e-25 87.6 2.4 8.8e-25 86.7 2.4 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ADV25337.1 - 1.6e-15 57.2 0.0 2.4e-15 56.7 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 ADV25337.1 - 0.0005 19.6 0.1 0.0098 15.4 0.0 2.1 2 0 0 2 2 2 1 Glucose dehydrogenase C-terminus Pyr_redox_2 PF07992.14 ADV25337.1 - 0.092 12.0 0.1 0.28 10.4 0.2 1.7 1 1 1 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DUF5527 PF17665.1 ADV25338.1 - 0.023 14.2 0.2 0.043 13.4 0.2 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5527) Ferritin_2 PF13668.6 ADV25339.1 - 1.6e-22 80.1 3.9 4.8e-14 52.7 0.1 2.4 1 1 1 2 2 2 2 Ferritin-like domain DUF4439 PF14530.6 ADV25339.1 - 0.0074 17.0 0.1 0.065 13.9 0.0 2.1 1 1 1 2 2 2 1 Domain of unknown function (DUF4439) Sugar_tr PF00083.24 ADV25340.1 - 1.3e-82 278.1 25.3 1.6e-82 277.8 25.3 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ADV25340.1 - 1.2e-16 60.6 35.3 3.1e-10 39.5 11.4 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Aminotran_4 PF01063.19 ADV25341.1 - 1e-12 48.4 0.0 8.2e-11 42.2 0.0 2.9 1 1 0 1 1 1 1 Amino-transferase class IV CorA PF01544.18 ADV25342.1 - 1.5e-29 103.2 9.6 1.4e-18 67.3 0.2 3.2 3 0 0 3 3 3 3 CorA-like Mg2+ transporter protein RRM_1 PF00076.22 ADV25344.1 - 1.6e-12 47.0 0.1 5.3e-06 26.1 0.0 4.2 4 1 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SSrecog PF03531.14 ADV25345.1 - 1.4e-28 98.6 0.1 3.2e-28 97.4 0.1 1.7 1 0 0 1 1 1 1 Structure-specific recognition protein (SSRP1) POB3_N PF17292.2 ADV25345.1 - 3.4e-27 94.7 0.3 1.7e-25 89.3 0.1 2.5 2 0 0 2 2 2 1 POB3-like N-terminal PH domain Rtt106 PF08512.12 ADV25345.1 - 3e-22 78.8 0.1 3.7e-21 75.3 0.0 2.3 2 0 0 2 2 2 1 Histone chaperone Rttp106-like adh_short_C2 PF13561.6 ADV25346.1 - 8.5e-31 107.3 0.7 8.1e-30 104.1 0.7 2.1 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ADV25346.1 - 7.1e-23 81.1 2.3 1.3e-16 60.7 0.1 2.7 1 1 1 2 2 2 2 short chain dehydrogenase KR PF08659.10 ADV25346.1 - 1.2e-06 28.6 2.2 1.3e-05 25.2 0.0 2.4 1 1 1 2 2 2 2 KR domain HATPase_c PF02518.26 ADV25346.1 - 0.022 15.3 0.1 0.19 12.3 0.1 2.1 1 1 1 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase EF-hand_1 PF00036.32 ADV25347.1 - 1.5e-23 80.5 14.6 2.5e-09 36.0 0.2 4.0 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 ADV25347.1 - 5.1e-22 78.1 8.0 2.4e-14 53.5 2.2 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ADV25347.1 - 1e-19 68.7 11.7 3.9e-08 32.6 0.1 4.1 4 2 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.6 ADV25347.1 - 6.3e-18 64.4 7.3 1.7e-12 47.0 0.7 3.2 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 ADV25347.1 - 8.5e-14 50.3 7.6 2.4e-05 23.6 0.1 3.4 3 0 0 3 3 3 3 EF hand EF-hand_9 PF14658.6 ADV25347.1 - 3.1e-12 46.6 0.3 1.1e-06 28.8 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 ADV25347.1 - 1.7e-10 40.8 0.0 5e-05 23.2 0.0 2.4 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand Caleosin PF05042.13 ADV25347.1 - 0.00032 20.7 0.1 0.13 12.2 0.0 3.1 2 1 1 3 3 3 1 Caleosin related protein SPARC_Ca_bdg PF10591.9 ADV25347.1 - 0.007 16.7 0.1 3 8.2 0.0 2.1 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region DUF3164 PF11363.8 ADV25347.1 - 0.016 14.8 0.2 2 8.0 0.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3164) Dockerin_1 PF00404.18 ADV25347.1 - 0.033 14.4 0.1 11 6.3 0.0 2.4 2 0 0 2 2 2 0 Dockerin type I domain PPR_1 PF12854.7 ADV25347.1 - 0.12 12.1 1.2 2.3 8.0 0.1 2.4 2 0 0 2 2 2 0 PPR repeat EF-hand_11 PF08976.11 ADV25347.1 - 0.12 13.3 0.1 0.49 11.3 0.0 1.9 2 0 0 2 2 2 0 EF-hand domain Cellulase PF00150.18 ADV25348.1 - 6.3e-16 58.6 0.0 9.3e-16 58.1 0.0 1.2 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) USP7_ICP0_bdg PF12436.8 ADV25349.1 - 3.1e-85 285.3 1.4 1.1e-84 283.5 0.2 2.4 3 0 0 3 3 3 1 ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 PF14533.6 ADV25349.1 - 5e-69 232.1 0.8 1.9e-62 210.6 0.0 3.5 3 0 0 3 3 3 3 Ubiquitin-specific protease C-terminal UCH PF00443.29 ADV25349.1 - 8.8e-52 176.1 0.1 1.6e-51 175.3 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ADV25349.1 - 2.9e-20 73.1 0.0 6.3e-20 72.0 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase MATH PF00917.26 ADV25349.1 - 8.8e-07 29.1 0.0 2.7e-06 27.5 0.0 1.9 1 0 0 1 1 1 1 MATH domain UN_NPL4 PF11543.8 ADV25349.1 - 0.052 14.0 0.4 17 6.0 0.0 4.0 3 1 1 4 4 4 0 Nuclear pore localisation protein NPL4 DUF1641 PF07849.11 ADV25351.1 - 0.11 12.4 0.1 0.23 11.3 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1641) DUF3368 PF11848.8 ADV25351.1 - 0.26 11.1 0.5 0.97 9.3 0.0 2.1 3 0 0 3 3 3 0 Domain of unknown function (DUF3368) NMO PF03060.15 ADV25352.1 - 1.9e-52 178.7 0.1 2.4e-52 178.4 0.1 1.1 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 ADV25352.1 - 1.9e-09 37.0 0.5 6.9e-09 35.2 0.5 1.7 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 ADV25352.1 - 0.00066 18.8 1.5 0.0011 18.0 1.5 1.3 1 0 0 1 1 1 1 FMN-dependent dehydrogenase DNA_pol_delta_4 PF04081.13 ADV25353.1 - 6.5e-31 107.4 1.4 1.1e-30 106.6 1.4 1.5 1 1 0 1 1 1 1 DNA polymerase delta, subunit 4 RhoGEF67_u1 PF16615.5 ADV25353.1 - 2.5 8.7 7.7 0.6 10.7 3.0 2.2 1 1 1 2 2 2 0 Unstructured region one on RhoGEF 6 and 7 Fungal_trans PF04082.18 ADV25354.1 - 1e-22 80.4 0.0 1.7e-22 79.8 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ADV25354.1 - 4.5e-09 36.3 13.4 8e-09 35.5 13.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SUIM_assoc PF16619.5 ADV25355.1 - 2.1 8.5 8.4 0.46 10.6 5.0 1.7 2 1 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 DLH PF01738.18 ADV25356.1 - 1.5e-11 44.2 0.1 1.6e-11 44.2 0.1 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Ribosomal_L19 PF01245.20 ADV25357.1 - 1e-15 57.6 0.2 1.5e-15 57.1 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L19 UCR_UQCRX_QCR9 PF05365.12 ADV25358.1 - 1.2e-27 95.6 4.4 1.3e-27 95.5 4.4 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like BNR_6 PF15899.5 ADV25358.1 - 0.016 15.2 0.8 0.027 14.5 0.8 1.4 1 0 0 1 1 1 0 BNR-Asp box repeat Tricorn_C1 PF14684.6 ADV25358.1 - 0.052 13.6 0.1 0.073 13.1 0.1 1.2 1 0 0 1 1 1 0 Tricorn protease C1 domain CIMR PF00878.18 ADV25359.1 - 2.3e-12 47.2 0.1 1.5e-06 28.4 0.0 2.2 2 0 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat Man-6-P_recep PF02157.15 ADV25359.1 - 2.6e-06 26.7 0.0 3.7e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 Mannose-6-phosphate receptor ATG27 PF09451.10 ADV25359.1 - 0.00022 21.2 0.0 0.0028 17.5 0.0 2.0 1 1 0 1 1 1 1 Autophagy-related protein 27 B_solenoid_dext PF18841.1 ADV25359.1 - 0.21 11.9 1.9 0.23 11.8 0.4 1.8 2 0 0 2 2 2 0 Beta solenoid repeat from Dextranase Complex1_49kDa PF00346.19 ADV25360.1 - 2.5e-119 397.4 0.0 3.1e-119 397.0 0.0 1.1 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit NiFeSe_Hases PF00374.19 ADV25360.1 - 0.0036 16.3 0.0 0.0052 15.7 0.0 1.3 1 0 0 1 1 1 1 Nickel-dependent hydrogenase IMD PF08397.11 ADV25361.1 - 0.00016 21.1 2.6 0.00023 20.6 2.6 1.2 1 0 0 1 1 1 1 IRSp53/MIM homology domain TAP42 PF04177.12 ADV25361.1 - 0.01 15.0 0.2 0.017 14.3 0.2 1.3 1 0 0 1 1 1 0 TAP42-like family ARD PF03079.14 ADV25361.1 - 0.048 13.8 0.1 0.075 13.2 0.1 1.2 1 0 0 1 1 1 0 ARD/ARD' family Vps5 PF09325.10 ADV25361.1 - 0.059 12.9 3.8 0.086 12.4 3.8 1.2 1 0 0 1 1 1 0 Vps5 C terminal like Alanine_zipper PF11839.8 ADV25361.1 - 1.8 9.0 7.5 0.83 10.1 3.8 2.1 2 0 0 2 2 2 0 Alanine-zipper, major outer membrane lipoprotein Solute_trans_a PF03619.16 ADV25362.1 - 7.1e-91 304.4 11.2 9.1e-91 304.0 11.2 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha SCO1-SenC PF02630.14 ADV25363.1 - 7.1e-48 161.9 0.0 1.1e-47 161.3 0.0 1.3 1 0 0 1 1 1 1 SCO1/SenC AhpC-TSA PF00578.21 ADV25363.1 - 4.3e-06 26.6 0.0 1.2e-05 25.3 0.0 1.7 1 1 0 1 1 1 1 AhpC/TSA family Thioredoxin_8 PF13905.6 ADV25363.1 - 0.012 16.0 0.0 0.024 15.0 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin-like Redoxin PF08534.10 ADV25363.1 - 0.018 14.8 0.1 0.18 11.5 0.1 2.1 1 1 0 1 1 1 0 Redoxin SASP_gamma PF04259.14 ADV25363.1 - 2 8.9 5.5 0.78 10.3 0.9 2.3 3 0 0 3 3 3 0 Small, acid-soluble spore protein, gamma-type Chorismate_synt PF01264.21 ADV25364.1 - 2.2e-135 450.6 0.1 2.6e-135 450.4 0.1 1.0 1 0 0 1 1 1 1 Chorismate synthase PAS PF00989.25 ADV25364.1 - 0.036 14.1 0.0 0.093 12.7 0.0 1.6 1 0 0 1 1 1 0 PAS fold JmjC PF02373.22 ADV25365.1 - 6.8e-39 132.8 0.1 1.6e-38 131.6 0.1 1.7 1 0 0 1 1 1 1 JmjC domain, hydroxylase zf-HC5HC2H PF13771.6 ADV25365.1 - 1e-15 57.7 0.0 2.1e-15 56.7 0.0 1.6 1 0 0 1 1 1 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 ADV25365.1 - 1.1e-13 51.3 0.3 2.4e-13 50.2 0.3 1.4 1 0 0 1 1 1 1 PHD-zinc-finger like domain JmjN PF02375.17 ADV25365.1 - 1.5e-11 44.0 0.2 3.6e-11 42.8 0.2 1.7 1 0 0 1 1 1 1 jmjN domain PHD PF00628.29 ADV25365.1 - 0.015 15.2 2.4 0.035 14.0 2.4 1.6 1 0 0 1 1 1 0 PHD-finger FANCL_C PF11793.8 ADV25365.1 - 1.7 8.9 4.8 0.46 10.7 1.5 1.8 2 0 0 2 2 2 0 FANCL C-terminal domain Mur_ligase_M PF08245.12 ADV25366.1 - 7.2e-05 22.9 0.0 0.013 15.5 0.0 2.6 2 1 0 2 2 2 2 Mur ligase middle domain TPR_1 PF00515.28 ADV25368.1 - 7.4e-08 31.9 0.4 0.011 15.6 0.1 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ADV25368.1 - 3.7e-07 29.8 0.7 0.15 12.3 0.0 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 ADV25368.1 - 1.6e-05 25.1 0.5 0.11 12.7 0.2 2.5 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 ADV25368.1 - 0.00052 20.6 2.2 0.056 14.1 0.1 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 ADV25368.1 - 0.00061 19.4 0.7 0.0021 17.7 0.1 2.2 2 0 0 2 2 2 1 TPR repeat TPR_14 PF13428.6 ADV25368.1 - 0.022 15.5 0.0 2.1 9.4 0.0 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ADV25368.1 - 0.035 14.3 1.1 0.28 11.4 1.0 2.3 1 1 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 ADV25368.1 - 0.11 13.0 0.2 4 8.0 0.0 2.4 1 1 1 2 2 2 0 Tetratricopeptide repeat Phosphodiest PF01663.22 ADV25369.1 - 2.8e-11 43.6 0.5 6e-11 42.5 0.3 1.7 2 0 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.18 ADV25369.1 - 0.0015 17.9 0.4 0.0026 17.1 0.4 1.2 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.23 ADV25369.1 - 0.0066 15.9 0.0 0.023 14.1 0.0 1.7 1 1 0 1 1 1 1 Sulfatase NIF3 PF01784.18 ADV25370.1 - 1.3e-66 224.8 0.0 1.5e-66 224.5 0.0 1.0 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) Phage-tail_2 PF09096.10 ADV25370.1 - 0.16 11.9 0.0 0.25 11.3 0.0 1.3 1 0 0 1 1 1 0 Baseplate structural protein, domain 2 2OG-FeII_Oxy_2 PF13532.6 ADV25371.1 - 3.5e-20 73.0 0.0 4.9e-20 72.6 0.0 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Sybindin PF04099.12 ADV25372.1 - 4.2e-22 78.6 0.0 5.2e-22 78.3 0.0 1.1 1 0 0 1 1 1 1 Sybindin-like family Glyco_hydro_5_C PF18564.1 ADV25373.1 - 2.6e-09 37.5 0.2 1.4e-08 35.1 0.1 2.2 1 1 1 2 2 2 1 Glycoside hydrolase family 5 C-terminal domain Cellulase PF00150.18 ADV25373.1 - 7.1e-08 32.2 0.6 3.2e-07 30.1 0.3 2.1 2 1 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) ResIII PF04851.15 ADV25374.1 - 5.4e-21 75.3 0.0 1e-20 74.4 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 ADV25374.1 - 1.7e-14 54.0 0.0 1.4e-13 50.9 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ADV25374.1 - 2.6e-12 47.1 0.0 4e-11 43.2 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SWI2_SNF2 PF18766.1 ADV25374.1 - 0.00058 19.6 0.0 0.0012 18.6 0.0 1.6 1 0 0 1 1 1 1 SWI2/SNF2 ATPase AAA_11 PF13086.6 ADV25374.1 - 0.0035 17.2 0.4 1.5 8.5 0.0 3.2 2 1 1 3 3 3 1 AAA domain AAA_30 PF13604.6 ADV25374.1 - 0.0049 16.6 0.0 0.017 14.8 0.0 1.9 2 1 0 2 2 2 1 AAA domain SNF2_N PF00176.23 ADV25374.1 - 0.015 14.0 0.0 0.033 12.9 0.0 1.5 1 0 0 1 1 1 0 SNF2 family N-terminal domain DUF2075 PF09848.9 ADV25374.1 - 0.016 14.5 0.0 0.028 13.7 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.6 ADV25374.1 - 0.095 13.0 0.2 0.84 9.9 0.0 2.7 2 1 0 2 2 2 0 AAA domain DUF1840 PF08895.11 ADV25374.1 - 0.099 13.0 0.1 0.21 11.9 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1840) BUD22 PF09073.10 ADV25375.1 - 1.4e-78 265.2 22.8 1.4e-78 265.2 22.8 2.0 2 0 0 2 2 2 1 BUD22 Indigoidine_A PF04227.12 ADV25376.1 - 1e-111 373.0 2.1 1.4e-111 372.5 2.1 1.2 1 0 0 1 1 1 1 Indigoidine synthase A like protein PfkB PF00294.24 ADV25376.1 - 6.2e-15 55.3 0.0 2.2e-06 27.2 0.0 2.9 2 1 0 2 2 2 2 pfkB family carbohydrate kinase zf-AN1 PF01428.16 ADV25377.1 - 0.0014 18.7 6.4 0.0029 17.7 6.4 1.5 1 0 0 1 1 1 1 AN1-like Zinc finger Transp_Tc5_C PF04236.15 ADV25377.1 - 0.25 11.7 4.1 1.3 9.4 4.2 2.1 2 0 0 2 2 2 0 Tc5 transposase C-terminal domain AAA_18 PF13238.6 ADV25378.1 - 7e-25 88.1 0.0 1.3e-24 87.2 0.0 1.4 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.6 ADV25378.1 - 0.00059 20.3 0.0 0.0017 18.8 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 ADV25378.1 - 0.0012 19.1 0.0 0.042 14.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 ADV25378.1 - 0.0015 19.0 0.0 0.0032 17.9 0.0 1.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 ADV25378.1 - 0.011 15.8 0.1 2.2 8.4 0.1 2.3 1 1 0 2 2 2 0 AAA domain DUF2075 PF09848.9 ADV25378.1 - 0.023 14.0 2.1 0.024 13.9 0.1 1.9 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) KTI12 PF08433.10 ADV25378.1 - 0.028 13.9 0.0 0.092 12.2 0.0 1.7 2 0 0 2 2 2 0 Chromatin associated protein KTI12 ATPase PF06745.13 ADV25378.1 - 0.028 13.8 0.0 0.053 12.9 0.0 1.4 1 0 0 1 1 1 0 KaiC AAA_28 PF13521.6 ADV25378.1 - 0.041 14.1 0.3 0.31 11.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 ADV25378.1 - 0.086 13.2 0.1 0.23 11.9 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain AAA_19 PF13245.6 ADV25378.1 - 0.097 13.0 1.0 0.25 11.7 0.2 1.9 1 1 1 2 2 2 0 AAA domain Sigma54_activ_2 PF14532.6 ADV25378.1 - 0.097 12.8 0.0 0.17 12.0 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain DUF853 PF05872.12 ADV25378.1 - 0.2 10.2 0.0 0.34 9.4 0.0 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) Kelch_3 PF13415.6 ADV25379.1 - 0.0037 17.5 2.5 0.02 15.2 0.4 3.2 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ADV25379.1 - 0.007 15.9 0.6 0.073 12.7 0.5 2.6 2 1 0 2 2 2 1 Kelch motif Kelch_6 PF13964.6 ADV25379.1 - 0.048 14.0 1.8 1.4 9.3 0.1 3.4 3 0 0 3 3 3 0 Kelch motif DUF5074 PF16819.5 ADV25379.1 - 0.073 13.1 0.5 0.073 13.1 0.5 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF5074) Kelch_4 PF13418.6 ADV25379.1 - 0.11 12.6 0.1 0.11 12.6 0.1 2.8 3 0 0 3 3 3 0 Galactose oxidase, central domain Macoilin PF09726.9 ADV25379.1 - 0.96 7.9 4.9 1.3 7.5 4.9 1.1 1 0 0 1 1 1 0 Macoilin family RAP1 PF07218.11 ADV25379.1 - 1.9 6.7 10.6 2.3 6.4 10.6 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) 2OG-FeII_Oxy_2 PF13532.6 ADV25380.1 - 2.3e-19 70.3 0.0 3.9e-19 69.6 0.0 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily E1-E2_ATPase PF00122.20 ADV25381.1 - 1.6e-51 174.4 0.2 1.6e-51 174.4 0.2 2.8 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 ADV25381.1 - 2.9e-44 151.0 8.2 8.7e-44 149.4 7.3 2.3 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 ADV25381.1 - 1.1e-21 78.1 0.2 3.2e-17 63.5 0.0 2.9 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ADV25381.1 - 4.3e-19 68.4 0.0 8.4e-19 67.4 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 ADV25381.1 - 1.1e-16 60.3 0.6 5.4e-16 58.0 0.0 2.4 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus HAD PF12710.7 ADV25381.1 - 1.3e-07 32.2 0.0 2.9e-07 31.1 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 ADV25381.1 - 1.7e-07 31.3 2.2 1.1e-05 25.4 1.5 2.6 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Whi5 PF08528.11 ADV25382.1 - 5.7e-08 32.2 0.0 9.7e-08 31.5 0.0 1.4 1 0 0 1 1 1 1 Whi5 like Glyco_transf_8 PF01501.20 ADV25383.1 - 2.3e-11 43.7 0.0 6.1e-11 42.4 0.0 1.7 1 1 1 2 2 2 1 Glycosyl transferase family 8 HTH_19 PF12844.7 ADV25383.1 - 0.078 13.0 0.9 0.16 12.0 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain zf-C2H2 PF00096.26 ADV25384.1 - 2.2e-06 27.8 16.5 3.8e-05 23.9 1.0 3.6 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ADV25384.1 - 5.6e-05 23.4 3.2 5.6e-05 23.4 3.2 2.6 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_jaz PF12171.8 ADV25384.1 - 0.0042 17.3 0.3 0.018 15.3 0.0 2.3 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 ADV25384.1 - 0.0053 17.5 0.8 0.0053 17.5 0.8 3.3 3 0 0 3 3 3 1 C2H2-type zinc finger zf-met PF12874.7 ADV25384.1 - 0.012 15.9 0.1 0.042 14.3 0.1 2.0 1 0 0 1 1 1 0 Zinc-finger of C2H2 type FOXP-CC PF16159.5 ADV25384.1 - 0.094 13.4 12.1 0.097 13.3 0.6 2.9 1 1 1 2 2 2 0 FOXP coiled-coil domain zf-C2H2_6 PF13912.6 ADV25384.1 - 1 9.5 9.6 0.052 13.6 1.9 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger Ras PF00071.22 ADV25385.1 - 1.4e-34 119.0 0.1 1.7e-34 118.8 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ADV25385.1 - 7.5e-26 90.7 0.1 1.3e-25 90.0 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ADV25385.1 - 2.6e-07 30.2 0.0 3.3e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ADV25385.1 - 5.5e-06 25.9 0.1 6.9e-06 25.6 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 ADV25385.1 - 0.016 14.6 0.0 0.023 14.1 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit TniB PF05621.11 ADV25385.1 - 0.021 14.2 0.0 2.6 7.4 0.0 2.1 2 0 0 2 2 2 0 Bacterial TniB protein PduV-EutP PF10662.9 ADV25385.1 - 0.024 14.4 0.1 0.093 12.5 0.1 1.8 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation DLIC PF05783.11 ADV25385.1 - 0.12 11.1 0.0 9.9 4.9 0.0 2.0 2 0 0 2 2 2 0 Dynein light intermediate chain (DLIC) TMF_DNA_bd PF12329.8 ADV25386.1 - 0.00089 19.2 0.9 0.00089 19.2 0.9 3.3 2 1 1 3 3 3 1 TATA element modulatory factor 1 DNA binding Pox_A_type_inc PF04508.12 ADV25386.1 - 0.02 14.8 0.5 0.24 11.3 0.0 2.7 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat Spc7 PF08317.11 ADV25386.1 - 0.022 13.6 9.7 0.014 14.3 3.5 2.3 2 0 0 2 2 2 0 Spc7 kinetochore protein PEARLI-4 PF05278.12 ADV25386.1 - 0.08 12.5 5.9 0.063 12.9 0.5 2.2 2 0 0 2 2 2 0 Arabidopsis phospholipase-like protein (PEARLI 4) PTPA PF03095.15 ADV25386.1 - 0.18 11.2 0.1 0.3 10.5 0.1 1.3 1 0 0 1 1 1 0 Phosphotyrosyl phosphate activator (PTPA) protein RB_A PF01858.17 ADV25386.1 - 0.29 10.9 3.1 2.4 7.9 0.2 2.8 2 1 1 3 3 3 0 Retinoblastoma-associated protein A domain DUF812 PF05667.11 ADV25386.1 - 0.45 9.3 10.7 0.2 10.5 4.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF812) FOXP-CC PF16159.5 ADV25386.1 - 0.5 11.0 0.1 0.5 11.0 0.1 2.9 3 0 0 3 3 3 0 FOXP coiled-coil domain CENP-F_leu_zip PF10473.9 ADV25386.1 - 0.94 9.5 18.5 0.15 12.1 4.0 3.3 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DASH_Dad4 PF08650.10 ADV25386.1 - 2.7 8.0 5.9 0.98 9.4 0.8 2.7 2 1 1 3 3 3 0 DASH complex subunit Dad4 DUF2730 PF10805.8 ADV25386.1 - 5.4 7.2 8.5 7.2 6.8 0.7 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF2730) Methyltransf_7 PF03492.15 ADV25387.1 - 0.0083 15.4 0.0 0.031 13.5 0.0 1.9 2 0 0 2 2 2 1 SAM dependent carboxyl methyltransferase HATPase_c PF02518.26 ADV25388.1 - 2.7e-45 153.5 0.0 4.5e-22 78.7 0.0 2.5 2 0 0 2 2 2 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ADV25388.1 - 2.8e-42 143.4 0.3 3.1e-22 78.9 0.0 2.5 2 0 0 2 2 2 2 Response regulator receiver domain HisKA PF00512.25 ADV25388.1 - 2e-17 63.0 0.7 3.3e-10 39.9 0.1 2.8 2 0 0 2 2 2 2 His Kinase A (phospho-acceptor) domain PAS_4 PF08448.10 ADV25388.1 - 2e-08 34.5 0.0 0.0067 16.7 0.0 3.0 2 0 0 2 2 2 2 PAS fold HATPase_c_3 PF13589.6 ADV25388.1 - 5.4e-06 26.3 0.0 0.073 12.9 0.0 2.6 2 0 0 2 2 2 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_3 PF08447.12 ADV25388.1 - 0.022 15.0 0.0 0.052 13.8 0.0 1.6 1 0 0 1 1 1 0 PAS fold CAMSAP_CC1 PF17095.5 ADV25388.1 - 0.54 10.1 4.0 1.5 8.8 4.0 1.7 1 0 0 1 1 1 0 Spectrin-binding region of Ca2+-Calmodulin MFS_1 PF07690.16 ADV25389.1 - 1.2e-27 96.8 35.9 5.7e-26 91.3 29.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1428 PF07237.11 ADV25389.1 - 0.12 12.6 0.0 0.31 11.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1428) DUF4538 PF15061.6 ADV25389.1 - 4.5 7.1 4.9 24 4.8 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4538) Ras PF00071.22 ADV25390.1 - 3.4e-52 176.3 0.0 4e-52 176.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ADV25390.1 - 2.1e-22 79.6 0.0 3.1e-22 79.0 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ADV25390.1 - 6.3e-06 25.7 0.0 7.5e-06 25.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family PAM2 PF07145.15 ADV25391.1 - 0.039 13.6 0.1 0.11 12.3 0.1 1.8 1 0 0 1 1 1 0 Ataxin-2 C-terminal region SPX PF03105.19 ADV25391.1 - 1.9 8.3 6.9 2.3 8.1 6.9 1.1 1 0 0 1 1 1 0 SPX domain Ashwin PF15323.6 ADV25391.1 - 7.9 6.4 11.0 12 5.9 11.0 1.2 1 0 0 1 1 1 0 Developmental protein GHMP_kinases_N PF00288.26 ADV25392.1 - 2.1e-11 43.9 5.1 2.4e-11 43.7 2.9 2.2 2 0 0 2 2 2 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 ADV25392.1 - 1e-07 32.2 0.1 8.9e-07 29.2 0.0 2.3 2 0 0 2 2 2 1 GHMP kinases C terminal DprA_WH PF17782.1 ADV25392.1 - 0.17 12.0 1.8 0.59 10.3 0.0 2.6 3 0 0 3 3 3 0 DprA winged helix domain DUF900 PF05990.12 ADV25393.1 - 0.0065 16.0 0.0 0.014 14.9 0.0 1.4 2 0 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF900) Abhydrolase_6 PF12697.7 ADV25393.1 - 0.0066 17.1 0.2 0.009 16.6 0.2 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF1350 PF07082.11 ADV25393.1 - 0.12 11.6 0.0 0.2 10.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1350) Fcf1 PF04900.12 ADV25396.1 - 1.4e-27 96.0 0.1 2.3e-27 95.3 0.1 1.4 1 0 0 1 1 1 1 Fcf1 HemY_N PF07219.13 ADV25396.1 - 0.36 11.0 2.8 0.73 10.1 2.8 1.4 1 0 0 1 1 1 0 HemY protein N-terminus Asparaginase PF00710.20 ADV25397.1 - 2.3e-61 206.7 0.0 3.5e-61 206.1 0.0 1.3 1 0 0 1 1 1 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 ADV25397.1 - 5.1e-17 62.1 0.0 8.3e-17 61.4 0.0 1.4 1 0 0 1 1 1 1 Glutaminase/Asparaginase C-terminal domain GTP_CH_N PF12471.8 ADV25398.1 - 4.4e-79 264.7 0.0 6.2e-79 264.3 0.0 1.2 1 0 0 1 1 1 1 GTP cyclohydrolase N terminal GTP_cyclohydro2 PF00925.20 ADV25398.1 - 3.1e-16 59.4 0.0 5e-16 58.7 0.0 1.3 1 0 0 1 1 1 1 GTP cyclohydrolase II SfsA PF03749.13 ADV25398.1 - 0.036 14.0 0.0 0.089 12.7 0.0 1.6 1 0 0 1 1 1 0 Sugar fermentation stimulation protein RE domain Neisseria_TspB PF05616.13 ADV25399.1 - 0.047 12.2 0.3 0.076 11.5 0.3 1.2 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein LCCL PF03815.19 ADV25400.1 - 1.2e-08 34.9 0.0 2e-08 34.2 0.0 1.3 1 0 0 1 1 1 1 LCCL domain RhoGEF PF00621.20 ADV25402.1 - 3.7e-27 95.8 0.0 7.5e-27 94.7 0.0 1.5 1 1 0 1 1 1 1 RhoGEF domain BAR PF03114.18 ADV25402.1 - 4.6e-05 23.2 0.0 7.5e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 BAR domain RabGAP-TBC PF00566.18 ADV25403.1 - 7.3e-33 114.0 0.0 1.1e-32 113.4 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF4604 PF15377.6 ADV25404.1 - 1.9e-30 106.5 19.0 2.4e-30 106.2 19.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) TFIIF_alpha PF05793.12 ADV25404.1 - 0.33 9.5 25.7 0.42 9.1 25.7 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) RR_TM4-6 PF06459.12 ADV25404.1 - 2.9 7.6 14.5 4.3 7.1 14.5 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Aminotran_1_2 PF00155.21 ADV25405.1 - 3.7e-79 266.5 0.0 4.2e-79 266.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Arf PF00025.21 ADV25406.1 - 4.4e-69 231.4 0.2 5.1e-69 231.2 0.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 ADV25406.1 - 1.2e-13 51.0 0.9 5.5e-08 32.4 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.13 ADV25406.1 - 8.9e-12 45.3 0.0 1.3e-11 44.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 ADV25406.1 - 4.7e-10 39.3 0.0 6e-10 39.0 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 ADV25406.1 - 6.7e-10 38.7 0.0 8.9e-10 38.3 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 ADV25406.1 - 1.7e-08 34.1 0.0 2.2e-08 33.8 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ADV25406.1 - 3.7e-07 30.2 0.0 5.9e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ADV25406.1 - 6e-05 22.7 0.0 0.00096 18.7 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA_18 PF13238.6 ADV25406.1 - 0.006 17.1 0.1 0.014 16.0 0.1 1.7 1 1 0 1 1 1 1 AAA domain cobW PF02492.19 ADV25406.1 - 0.032 13.8 0.0 0.59 9.7 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain PduV-EutP PF10662.9 ADV25406.1 - 0.052 13.3 0.0 0.097 12.4 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation NACHT PF05729.12 ADV25406.1 - 0.17 11.8 0.3 0.69 9.8 0.0 1.9 1 1 1 2 2 2 0 NACHT domain Transp_cyt_pur PF02133.15 ADV25407.1 - 1.8e-93 313.7 44.2 2.2e-93 313.5 44.2 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin SUR7 PF06687.12 ADV25407.1 - 0.052 13.2 0.1 0.052 13.2 0.1 3.6 3 1 1 4 4 4 0 SUR7/PalI family Aminotran_5 PF00266.19 ADV25408.1 - 6.5e-24 84.6 0.0 4.8e-23 81.7 0.0 1.9 1 1 0 1 1 1 1 Aminotransferase class-V GGACT PF06094.12 ADV25408.1 - 2.5e-10 41.0 0.0 1.1e-09 39.0 0.0 2.1 2 1 0 2 2 2 1 Gamma-glutamyl cyclotransferase, AIG2-like Aminotran_1_2 PF00155.21 ADV25408.1 - 1.2e-05 24.7 0.0 2.5e-05 23.7 0.0 1.4 1 1 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 ADV25408.1 - 0.0031 16.9 0.6 0.076 12.3 0.2 2.0 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 ADV25408.1 - 0.14 10.7 0.0 4.6 5.7 0.0 2.1 1 1 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Ras PF00071.22 ADV25409.1 - 3.1e-51 173.2 0.2 3.9e-51 172.9 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ADV25409.1 - 3.6e-32 111.1 0.2 5.2e-32 110.6 0.2 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ADV25409.1 - 1.8e-12 47.0 0.3 2.2e-12 46.8 0.3 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 ADV25409.1 - 3.1e-05 23.9 0.1 0.034 14.0 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 ADV25409.1 - 0.0031 17.0 0.1 0.17 11.4 0.1 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B SRPRB PF09439.10 ADV25409.1 - 0.0074 15.7 0.1 0.014 14.9 0.1 1.5 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 ADV25409.1 - 0.016 15.3 0.1 0.034 14.2 0.1 1.6 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_7 PF12775.7 ADV25409.1 - 0.067 12.7 0.0 0.16 11.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region Gtr1_RagA PF04670.12 ADV25409.1 - 0.071 12.4 0.1 0.099 12.0 0.1 1.3 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region GATase PF00117.28 ADV25411.1 - 1.6e-05 24.8 0.6 5.4e-05 23.0 0.6 1.7 1 1 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 ADV25411.1 - 0.015 15.0 0.0 0.029 14.1 0.0 1.5 1 0 0 1 1 1 0 Peptidase C26 eIF3_N PF09440.10 ADV25412.1 - 2.4e-42 144.5 1.2 5.1e-42 143.5 1.2 1.6 1 0 0 1 1 1 1 eIF3 subunit 6 N terminal domain PCI PF01399.27 ADV25412.1 - 3e-08 34.1 0.1 8.5e-08 32.7 0.1 1.9 1 0 0 1 1 1 1 PCI domain K_channel_TID PF07941.11 ADV25413.1 - 4.4 7.8 6.6 4 8.0 5.3 1.6 1 1 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain Syja_N PF02383.18 ADV25414.1 - 2.6e-82 276.7 0.0 3.5e-82 276.3 0.0 1.2 1 0 0 1 1 1 1 SacI homology domain hSac2 PF12456.8 ADV25414.1 - 4.5e-34 116.6 0.0 1e-33 115.5 0.0 1.6 1 0 0 1 1 1 1 Inositol phosphatase PRMT5_C PF17286.2 ADV25414.1 - 0.043 13.7 0.0 0.073 12.9 0.0 1.4 1 0 0 1 1 1 0 PRMT5 oligomerisation domain Zn_clus PF00172.18 ADV25415.1 - 1e-06 28.7 7.7 1e-06 28.7 7.7 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 ADV25415.1 - 0.00054 19.1 0.0 0.12 11.4 0.0 2.4 2 0 0 2 2 2 2 Fungal specific transcription factor domain Bromodomain PF00439.25 ADV25416.1 - 2.3e-21 75.7 0.0 8.3e-15 54.6 0.0 2.6 2 0 0 2 2 2 2 Bromodomain BAH PF01426.18 ADV25416.1 - 1.5e-11 44.2 0.0 2.8e-11 43.3 0.0 1.5 1 0 0 1 1 1 1 BAH domain CN_hydrolase PF00795.22 ADV25417.1 - 7.3e-23 81.2 0.0 3.5e-13 49.5 0.0 2.1 2 0 0 2 2 2 2 Carbon-nitrogen hydrolase Y_phosphatase PF00102.27 ADV25418.1 - 2.5e-33 115.6 0.0 3.2e-33 115.2 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 ADV25418.1 - 0.0001 22.2 0.0 0.00024 20.9 0.0 1.6 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 ADV25418.1 - 0.00027 21.1 0.0 0.00066 19.8 0.0 1.7 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 ADV25418.1 - 0.0062 16.5 0.0 0.011 15.7 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family COX15-CtaA PF02628.15 ADV25419.1 - 2.7e-109 365.2 2.5 3.2e-109 364.9 2.5 1.0 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein 7TMR-DISM_7TM PF07695.11 ADV25419.1 - 1.1 9.1 8.6 0.35 10.8 0.5 2.8 3 1 0 3 3 3 0 7TM diverse intracellular signalling RSN1_7TM PF02714.15 ADV25420.1 - 1.1e-77 261.1 22.1 2.4e-77 259.9 22.1 1.6 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 ADV25420.1 - 2.7e-28 98.7 2.0 6e-28 97.6 0.4 2.5 2 0 0 2 2 2 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 ADV25420.1 - 5.1e-26 92.0 0.0 9e-26 91.2 0.0 1.4 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter Es2 PF09751.9 ADV25421.1 - 1.2e-80 272.4 5.3 2.5e-80 271.4 5.3 1.5 1 1 0 1 1 1 1 Nuclear protein Es2 Yip1 PF04893.17 ADV25423.1 - 1.3e-07 31.6 7.7 1.4e-07 31.4 7.7 1.1 1 0 0 1 1 1 1 Yip1 domain PfkB PF00294.24 ADV25426.1 - 2.2e-12 46.9 0.0 3.2e-12 46.4 0.0 1.2 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Aldo_ket_red PF00248.21 ADV25429.1 - 8.7e-65 218.8 0.0 1e-64 218.6 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Pex14_N PF04695.13 ADV25430.1 - 8.4e-30 104.5 0.2 1.6e-28 100.4 0.0 2.5 2 0 0 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF1759 PF03564.15 ADV25430.1 - 2.1e-05 24.5 0.1 3.6e-05 23.8 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1759) Laminin_II PF06009.12 ADV25430.1 - 4.5e-05 23.5 3.9 8.2e-05 22.6 3.9 1.4 1 0 0 1 1 1 1 Laminin Domain II DUF4226 PF10774.9 ADV25430.1 - 0.0011 19.2 0.8 0.0032 17.7 0.1 2.0 3 0 0 3 3 2 1 Domain of unknown function (DUF4226) TPR_MLP1_2 PF07926.12 ADV25430.1 - 0.0081 16.2 3.3 0.0081 16.2 3.3 2.4 2 1 0 3 3 2 1 TPR/MLP1/MLP2-like protein FapA PF03961.13 ADV25430.1 - 0.0082 14.8 0.8 0.012 14.3 0.8 1.2 1 0 0 1 1 1 1 Flagellar Assembly Protein A Fib_alpha PF08702.10 ADV25430.1 - 0.0085 16.3 2.5 0.015 15.4 2.5 1.4 1 0 0 1 1 1 1 Fibrinogen alpha/beta chain family Baculo_PEP_C PF04513.12 ADV25430.1 - 0.022 14.8 0.0 0.036 14.1 0.0 1.3 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Prominin PF05478.11 ADV25430.1 - 0.027 12.5 0.2 0.034 12.1 0.2 1.0 1 0 0 1 1 1 0 Prominin LXG PF04740.12 ADV25430.1 - 0.034 13.9 2.7 0.11 12.1 2.5 1.8 1 1 1 2 2 2 0 LXG domain of WXG superfamily Spc7 PF08317.11 ADV25430.1 - 0.035 13.0 6.9 0.044 12.7 4.3 1.6 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF1664 PF07889.12 ADV25430.1 - 0.037 14.1 5.0 0.44 10.6 3.5 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) CREPT PF16566.5 ADV25430.1 - 0.041 14.0 2.8 0.088 13.0 1.8 1.8 1 1 1 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour Zw10 PF06248.13 ADV25430.1 - 0.042 12.4 2.0 0.07 11.7 2.0 1.3 1 0 0 1 1 1 0 Centromere/kinetochore Zw10 zf-C4H2 PF10146.9 ADV25430.1 - 0.05 13.9 0.0 0.083 13.2 0.0 1.3 1 0 0 1 1 1 0 Zinc finger-containing protein IFT57 PF10498.9 ADV25430.1 - 0.053 12.5 6.1 0.17 10.8 3.5 2.0 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 UPF0242 PF06785.11 ADV25430.1 - 0.082 13.0 0.9 0.18 11.9 0.9 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus V_ATPase_I PF01496.19 ADV25430.1 - 0.088 10.7 1.1 0.12 10.3 1.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SHE3 PF17078.5 ADV25430.1 - 0.097 12.4 2.5 0.15 11.8 2.5 1.2 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 BST2 PF16716.5 ADV25430.1 - 0.11 13.1 3.8 0.76 10.4 0.9 2.4 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 DUF948 PF06103.11 ADV25430.1 - 0.11 12.8 2.9 0.39 11.0 2.0 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF3584 PF12128.8 ADV25430.1 - 0.11 10.0 4.2 0.15 9.5 4.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Vps5 PF09325.10 ADV25430.1 - 0.12 11.9 3.6 0.17 11.4 2.9 1.6 1 1 0 1 1 1 0 Vps5 C terminal like KASH_CCD PF14662.6 ADV25430.1 - 0.15 11.9 6.5 0.3 10.9 6.5 1.5 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH NPV_P10 PF05531.12 ADV25430.1 - 0.15 12.5 2.9 4.5 7.8 2.9 2.6 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein LMBR1 PF04791.16 ADV25430.1 - 0.17 10.7 0.1 0.24 10.3 0.1 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Serglycin PF04360.12 ADV25430.1 - 0.17 11.8 11.5 0.39 10.6 0.4 3.3 3 0 0 3 3 3 0 Serglycin HIP1_clath_bdg PF16515.5 ADV25430.1 - 0.24 12.0 7.1 0.47 11.1 7.1 1.5 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF1043 PF06295.12 ADV25430.1 - 0.25 11.4 3.9 6.3 6.8 0.3 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF1043) TMPIT PF07851.13 ADV25430.1 - 0.29 10.3 1.7 0.53 9.5 1.7 1.4 1 0 0 1 1 1 0 TMPIT-like protein Jnk-SapK_ap_N PF09744.9 ADV25430.1 - 0.39 10.9 7.7 1 9.5 7.8 1.6 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 MscS_porin PF12795.7 ADV25430.1 - 0.42 10.1 6.9 1.6 8.2 5.9 2.1 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain Med9 PF07544.13 ADV25430.1 - 0.42 10.7 5.2 11 6.2 1.0 2.8 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 COG2 PF06148.11 ADV25430.1 - 0.71 10.0 6.9 2.2 8.4 3.4 2.3 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 OmpH PF03938.14 ADV25430.1 - 1 9.7 5.4 1.1 9.6 3.5 2.0 2 1 0 2 2 1 0 Outer membrane protein (OmpH-like) Muted PF14942.6 ADV25430.1 - 1.5 9.2 6.2 3.2 8.1 0.3 2.3 1 1 1 2 2 2 0 Organelle biogenesis, Muted-like protein TolA_bind_tri PF16331.5 ADV25430.1 - 4.3 7.5 8.0 21 5.2 1.8 3.2 2 1 0 2 2 2 0 TolA binding protein trimerisation Methyltransf_11 PF08241.12 ADV25431.1 - 4.5e-14 52.9 0.0 7.5e-13 48.9 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 ADV25431.1 - 1.2e-12 48.3 0.0 3.8e-12 46.7 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 ADV25431.1 - 3e-09 37.5 0.0 9.5e-09 35.9 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 ADV25431.1 - 5.4e-06 26.3 0.0 2.3e-05 24.3 0.0 2.0 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_23 PF13489.6 ADV25431.1 - 0.00016 21.6 0.0 0.00027 20.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain DREV PF05219.12 ADV25431.1 - 0.0095 15.1 0.0 0.015 14.4 0.0 1.2 1 0 0 1 1 1 1 DREV methyltransferase Ubie_methyltran PF01209.18 ADV25431.1 - 0.02 14.3 0.0 0.031 13.6 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family MTS PF05175.14 ADV25431.1 - 0.21 11.1 0.0 0.35 10.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain CAP59_mtransfer PF11735.8 ADV25434.1 - 2.8e-54 184.3 0.0 3.5e-54 184.0 0.0 1.1 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 FAD_binding_6 PF00970.24 ADV25435.1 - 5.3e-33 113.3 0.0 8.3e-33 112.7 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 ADV25435.1 - 1.7e-31 109.1 0.0 2.4e-31 108.6 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 ADV25435.1 - 1.4e-06 28.5 0.0 2.3e-05 24.5 0.0 2.3 2 0 0 2 2 2 1 Ferric reductase NAD binding domain FAD_binding_9 PF08021.11 ADV25435.1 - 0.022 15.0 0.0 0.037 14.2 0.0 1.4 1 0 0 1 1 1 0 Siderophore-interacting FAD-binding domain tRNA_anti-codon PF01336.25 ADV25435.1 - 0.13 12.3 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain Aldedh PF00171.22 ADV25436.1 - 1.2e-59 202.1 0.0 1.7e-59 201.6 0.0 1.2 1 0 0 1 1 1 1 Aldehyde dehydrogenase family SUZ PF12752.7 ADV25438.1 - 6.8e-12 46.0 0.3 6.8e-12 46.0 0.3 4.8 3 1 0 3 3 3 1 SUZ domain Menin PF05053.13 ADV25438.1 - 7.1 4.8 5.9 11 4.2 5.9 1.3 1 0 0 1 1 1 0 Menin Tfb4 PF03850.14 ADV25439.1 - 8e-24 84.6 0.0 1.3e-23 83.9 0.0 1.3 1 0 0 1 1 1 1 Transcription factor Tfb4 CHAT PF12770.7 ADV25441.1 - 0.011 15.2 0.0 0.014 14.8 0.0 1.3 1 0 0 1 1 1 0 CHAT domain tRNA_Me_trans PF03054.16 ADV25443.1 - 2.3e-93 312.8 0.0 7.7e-93 311.1 0.0 1.7 1 1 0 1 1 1 1 tRNA methyl transferase NAD_synthase PF02540.17 ADV25443.1 - 0.00076 18.7 0.0 1.4 8.0 0.0 2.5 3 0 0 3 3 3 2 NAD synthase DUF1279 PF06916.13 ADV25444.1 - 1.1e-26 93.2 0.0 1.7e-26 92.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1279) DUF5427 PF10310.9 ADV25444.1 - 0.11 11.5 3.1 0.71 8.8 0.3 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5427) Rap1_C PF11626.8 ADV25445.1 - 0.014 15.4 0.1 0.022 14.8 0.1 1.2 1 0 0 1 1 1 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain STATa_Ig PF18214.1 ADV25445.1 - 0.096 12.7 0.0 0.14 12.1 0.0 1.2 1 0 0 1 1 1 0 STATa Immunoglobulin-like domain PHD PF00628.29 ADV25446.1 - 0.023 14.6 4.8 0.15 12.0 0.1 2.7 3 0 0 3 3 3 0 PHD-finger EIIBC-GUT_N PF03612.14 ADV25446.1 - 0.025 14.3 0.1 0.49 10.1 0.0 2.3 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus Rubredoxin_2 PF18073.1 ADV25446.1 - 0.089 12.5 0.1 0.19 11.5 0.1 1.6 1 0 0 1 1 1 0 Rubredoxin metal binding domain DUF3408 PF11888.8 ADV25446.1 - 0.15 12.2 0.2 0.15 12.2 0.2 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3408) Pox_Ag35 PF03286.14 ADV25446.1 - 0.27 11.0 6.5 0.061 13.1 2.1 2.0 2 0 0 2 2 2 0 Pox virus Ag35 surface protein Nucleo_P87 PF07267.11 ADV25446.1 - 0.97 8.2 6.2 0.35 9.7 2.3 2.0 2 0 0 2 2 2 0 Nucleopolyhedrovirus capsid protein P87 RPA43_OB PF17875.1 ADV25446.1 - 1 10.0 6.2 0.17 12.5 1.3 2.0 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I FAM176 PF14851.6 ADV25446.1 - 1.3 8.7 8.6 0.081 12.6 2.8 2.0 2 0 0 2 2 2 0 FAM176 family CCDC53 PF10152.9 ADV25446.1 - 5.8 7.3 6.7 0.71 10.3 0.2 2.4 2 1 0 2 2 2 0 Subunit CCDC53 of WASH complex Pap_E4 PF02711.14 ADV25446.1 - 6.6 7.8 6.6 1.7 9.6 0.8 2.5 2 0 0 2 2 2 0 E4 protein RR_TM4-6 PF06459.12 ADV25446.1 - 8.9 6.0 8.9 0.26 11.1 0.6 2.2 3 0 0 3 3 3 0 Ryanodine Receptor TM 4-6 WD40 PF00400.32 ADV25447.1 - 7.1e-16 58.3 2.1 0.0083 17.0 0.0 5.4 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV25447.1 - 1.3e-11 44.7 0.0 1.7e-07 31.4 0.0 3.7 2 2 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 ADV25447.1 - 0.016 14.0 0.1 4 6.1 0.0 2.3 2 0 0 2 2 2 0 Nup133 N terminal like eIF2A PF08662.11 ADV25447.1 - 0.02 14.8 0.1 0.11 12.4 0.0 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ADV25447.1 - 0.026 13.5 0.1 0.12 11.3 0.0 2.0 1 1 2 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ADV25447.1 - 0.041 12.5 0.2 0.5 8.9 0.0 2.2 1 1 0 2 2 2 0 Nucleoporin Nup120/160 PQQ_3 PF13570.6 ADV25447.1 - 0.074 13.6 0.3 12 6.5 0.0 4.2 6 1 0 6 6 6 0 PQQ-like domain VID27 PF08553.10 ADV25447.1 - 0.082 12.0 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 VID27 C-terminal WD40-like domain Syja_N PF02383.18 ADV25448.1 - 5.3e-85 285.5 0.0 7.5e-85 285.0 0.0 1.2 1 0 0 1 1 1 1 SacI homology domain GMC_oxred_N PF00732.19 ADV25449.1 - 4.1e-60 203.7 0.0 6.4e-60 203.0 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 ADV25449.1 - 2.6e-31 109.1 0.2 6e-31 107.9 0.0 1.8 2 0 0 2 2 2 1 GMC oxidoreductase SKG6 PF08693.10 ADV25449.1 - 3.4e-05 23.2 0.1 3.4e-05 23.2 0.1 1.8 2 0 0 2 2 2 1 Transmembrane alpha-helix domain NAD_binding_8 PF13450.6 ADV25449.1 - 0.0012 19.1 0.1 0.0039 17.4 0.1 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 ADV25449.1 - 0.0032 16.6 0.1 0.0057 15.7 0.1 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein DAO PF01266.24 ADV25449.1 - 0.0097 15.5 0.0 0.02 14.5 0.0 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 ADV25449.1 - 0.025 13.7 0.4 0.16 11.1 0.4 2.0 2 0 0 2 2 2 0 FAD binding domain Cytomega_US3 PF05963.11 ADV25449.1 - 0.025 14.2 0.0 0.051 13.2 0.0 1.4 1 0 0 1 1 1 0 Cytomegalovirus US3 protein Pyr_redox_2 PF07992.14 ADV25449.1 - 0.035 13.3 0.0 0.069 12.4 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase WSC PF01822.19 ADV25450.1 - 0.0079 16.4 1.6 0.0079 16.4 1.6 3.2 3 2 0 3 3 3 2 WSC domain PLA2_B PF01735.18 ADV25451.1 - 7.1e-119 397.4 1.9 8.8e-119 397.1 1.9 1.1 1 0 0 1 1 1 1 Lysophospholipase catalytic domain Spc7 PF08317.11 ADV25452.1 - 5.4e-71 239.0 11.1 8.7e-71 238.3 11.1 1.3 1 0 0 1 1 1 1 Spc7 kinetochore protein Spc7_C2 PF15577.6 ADV25452.1 - 5.9e-11 42.3 0.2 1.5e-10 41.0 0.1 1.8 2 0 0 2 2 2 1 Spc7_C2 RapA_C PF12137.8 ADV25452.1 - 0.0077 15.3 2.1 0.017 14.2 2.1 1.6 1 0 0 1 1 1 1 RNA polymerase recycling family C-terminal DUF267 PF03268.14 ADV25452.1 - 0.098 11.5 0.1 0.15 10.9 0.1 1.2 1 0 0 1 1 1 0 Caenorhabditis protein of unknown function, DUF267 PDDEXK_3 PF13366.6 ADV25452.1 - 0.15 12.4 0.0 0.3 11.5 0.0 1.4 1 0 0 1 1 1 0 PD-(D/E)XK nuclease superfamily Cyclin_N PF00134.23 ADV25455.1 - 4.7e-37 126.6 1.0 7.9e-37 125.8 0.3 1.7 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 ADV25455.1 - 2.8e-10 40.3 0.0 7.9e-10 38.9 0.0 1.9 1 1 0 1 1 1 1 Cyclin, C-terminal domain Ribosomal_L13e PF01294.18 ADV25456.1 - 2.9e-71 239.0 2.1 3.9e-71 238.6 2.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L13e Mito_carr PF00153.27 ADV25457.1 - 5.5e-30 103.1 6.1 5.1e-14 52.0 0.1 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 ADV25457.1 - 0.0067 15.6 1.1 0.012 14.7 0.1 2.0 2 1 0 2 2 2 1 Gammaproteobacterial serine protease Zn_clus PF00172.18 ADV25458.1 - 1e-05 25.6 11.3 2e-05 24.6 11.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 ADV25458.1 - 0.00031 19.9 0.4 0.0022 17.1 0.4 2.0 1 1 0 1 1 1 1 Fungal specific transcription factor domain MerR-DNA-bind PF09278.11 ADV25458.1 - 0.17 12.5 0.2 0.48 11.0 0.2 1.8 1 0 0 1 1 1 0 MerR, DNA binding DnaJ_C PF01556.18 ADV25460.1 - 3.2e-35 121.4 0.3 4.3e-35 121.0 0.3 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 ADV25460.1 - 1.8e-26 92.1 2.8 2.7e-26 91.5 2.8 1.3 1 0 0 1 1 1 1 DnaJ domain DUF4131 PF13567.6 ADV25460.1 - 0.094 12.4 0.1 0.15 11.7 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) CPSase_L_D2 PF02786.17 ADV25462.1 - 1.7e-109 364.2 0.1 4.4e-84 281.2 0.0 2.5 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_D3 PF02787.19 ADV25462.1 - 2.3e-38 131.3 0.4 7.5e-38 129.6 0.3 2.0 2 0 0 2 2 2 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain ATP-grasp PF02222.22 ADV25462.1 - 1.4e-16 60.5 0.1 2.1e-07 30.7 0.0 2.4 2 0 0 2 2 2 2 ATP-grasp domain Dala_Dala_lig_C PF07478.13 ADV25462.1 - 4.8e-12 45.8 0.2 4.2e-05 23.2 0.1 2.4 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.6 ADV25462.1 - 5.8e-12 45.5 0.0 6.2e-06 26.0 0.0 2.7 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon MGS PF02142.22 ADV25462.1 - 4.4e-05 23.6 0.1 0.00024 21.2 0.0 2.4 2 1 0 2 2 2 1 MGS-like domain ATP-grasp_5 PF13549.6 ADV25462.1 - 0.00038 20.0 0.0 0.41 10.1 0.0 2.6 2 0 0 2 2 2 2 ATP-grasp domain RimK PF08443.11 ADV25462.1 - 0.0014 18.3 0.0 0.25 10.9 0.0 2.6 2 0 0 2 2 2 2 RimK-like ATP-grasp domain Peptidase_M17_N PF02789.17 ADV25462.1 - 0.012 15.4 0.1 0.051 13.4 0.1 2.0 2 0 0 2 2 2 0 Cytosol aminopeptidase family, N-terminal domain Stm1_N PF09598.10 ADV25463.1 - 1.4e-09 38.6 5.5 1.4e-09 38.6 5.5 4.3 5 1 0 5 5 5 1 Stm1 HABP4_PAI-RBP1 PF04774.15 ADV25463.1 - 4e-06 27.7 11.2 4e-06 27.7 11.2 2.5 3 0 0 3 3 3 1 Hyaluronan / mRNA binding family Ras PF00071.22 ADV25464.1 - 1.7e-57 193.6 0.0 2.6e-57 193.0 0.0 1.3 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ADV25464.1 - 1.4e-35 122.1 0.0 2.3e-35 121.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ADV25464.1 - 8.5e-17 61.1 0.0 1.4e-16 60.4 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ADV25464.1 - 2e-06 27.5 0.1 3.4e-06 26.7 0.0 1.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ADV25464.1 - 7.7e-06 26.0 0.0 1.4e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ADV25464.1 - 3.7e-05 23.2 0.0 4.9e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_16 PF13191.6 ADV25464.1 - 0.0067 16.8 2.6 0.017 15.5 2.5 1.8 1 1 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 ADV25464.1 - 0.063 13.2 0.1 3.4 7.5 0.0 2.6 3 0 0 3 3 3 0 RsgA GTPase His_Phos_2 PF00328.22 ADV25465.1 - 1.7e-06 27.7 0.0 0.03 13.7 0.0 2.3 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 2) CDP-OH_P_transf PF01066.21 ADV25468.1 - 6.1e-16 58.9 0.8 6.1e-16 58.9 0.8 2.5 3 0 0 3 3 3 1 CDP-alcohol phosphatidyltransferase DnaJ PF00226.31 ADV25469.1 - 5.4e-09 36.0 0.3 0.00023 21.2 0.0 2.3 2 0 0 2 2 2 2 DnaJ domain Ribosomal_S8e PF01201.22 ADV25471.1 - 3.3e-42 143.9 14.0 4.9e-41 140.1 14.0 2.4 1 1 0 1 1 1 1 Ribosomal protein S8e Med7 PF05983.11 ADV25472.1 - 5.7e-39 134.2 0.3 6.6e-39 134.0 0.3 1.0 1 0 0 1 1 1 1 MED7 protein HAUS6_N PF14661.6 ADV25472.1 - 3.5 7.1 6.5 0.16 11.5 0.6 1.7 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus NRDE-2 PF08424.10 ADV25473.1 - 1.5e-77 260.9 0.8 1e-75 254.8 0.0 3.0 3 0 0 3 3 3 2 NRDE-2, necessary for RNA interference TPR_14 PF13428.6 ADV25473.1 - 0.32 11.9 16.7 3.2 8.8 1.1 6.6 6 2 2 8 8 8 0 Tetratricopeptide repeat HAD_2 PF13419.6 ADV25474.1 - 1.1e-21 77.7 0.0 1.4e-21 77.4 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ADV25474.1 - 2.1e-10 41.3 0.1 9.4e-10 39.1 0.1 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ADV25474.1 - 1.7e-05 24.8 0.0 2.9e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 ADV25474.1 - 0.029 14.8 0.0 0.04 14.3 0.0 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase bZIP_1 PF00170.21 ADV25475.1 - 1.5e-10 41.0 2.0 1.5e-10 41.0 2.0 3.0 3 0 0 3 3 3 1 bZIP transcription factor bZIP_2 PF07716.15 ADV25475.1 - 1.4e-08 34.7 13.4 1.5e-07 31.4 7.6 2.7 2 0 0 2 2 2 2 Basic region leucine zipper Peptidase_M57 PF12388.8 ADV25475.1 - 0.1 12.2 0.2 0.17 11.4 0.2 1.3 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase DivIC PF04977.15 ADV25475.1 - 1.6 8.5 9.6 6.7 6.6 0.4 3.5 2 1 1 3 3 3 0 Septum formation initiator Zn_clus PF00172.18 ADV25477.1 - 0.12 12.5 3.0 0.24 11.5 3.0 1.4 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain COPI_C PF06957.11 ADV25478.1 - 0.13 11.0 6.1 0.19 10.4 6.1 1.2 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus G-patch PF01585.23 ADV25479.1 - 1.8e-08 34.1 0.1 4.4e-08 32.9 0.1 1.7 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 ADV25479.1 - 0.029 14.5 0.2 0.029 14.5 0.2 4.0 3 1 0 3 3 3 0 G-patch domain GTP_EFTU PF00009.27 ADV25480.1 - 1.5e-53 181.3 0.0 2.3e-53 180.6 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 ADV25480.1 - 2.3e-42 143.9 0.0 4.6e-42 142.8 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 ADV25480.1 - 3.5e-14 53.0 1.1 3.5e-14 53.0 1.1 2.2 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 ADV25480.1 - 7.4e-06 26.0 0.1 0.0022 18.0 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase FlpD PF02662.16 ADV25480.1 - 0.0093 16.0 0.0 0.043 13.8 0.0 2.0 2 0 0 2 2 2 1 Methyl-viologen-reducing hydrogenase, delta subunit Semialdhyde_dhC PF02774.18 ADV25480.1 - 0.14 12.2 0.4 0.41 10.7 0.1 1.8 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, dimerisation domain GTP_EFTU_D4 PF14578.6 ADV25480.1 - 0.41 10.6 2.8 0.34 10.8 0.6 2.0 2 0 0 2 2 2 0 Elongation factor Tu domain 4 tRNA-synt_1 PF00133.22 ADV25481.1 - 1.1e-39 136.2 0.1 1.4e-30 106.1 0.0 3.7 3 1 0 3 3 3 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 ADV25481.1 - 2.7e-18 65.9 0.0 1.3e-10 40.6 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (M) Anticodon_1 PF08264.13 ADV25481.1 - 3.9e-17 62.6 0.0 7.5e-17 61.7 0.0 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 ADV25481.1 - 4e-09 36.2 0.0 6.8e-09 35.5 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain DUF1304 PF06993.12 ADV25481.1 - 0.0057 16.6 0.0 0.012 15.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1304) HAD_2 PF13419.6 ADV25482.1 - 8.1e-22 78.2 0.0 9.9e-22 77.9 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ADV25482.1 - 1.1e-12 48.7 0.1 5e-11 43.3 0.1 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ADV25482.1 - 0.00024 21.1 0.1 0.0005 20.1 0.1 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 ADV25482.1 - 0.0099 16.3 0.0 0.012 16.0 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Stimulus_sens_1 PF13756.6 ADV25482.1 - 0.15 12.6 0.0 0.25 11.9 0.0 1.4 1 0 0 1 1 1 0 Stimulus-sensing domain SNF2_N PF00176.23 ADV25484.1 - 7.7e-46 156.4 4.6 2.1e-26 92.5 0.0 3.3 2 1 1 3 3 3 3 SNF2 family N-terminal domain Helicase_C PF00271.31 ADV25484.1 - 9.2e-21 74.3 0.0 2.8e-20 72.7 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 ADV25484.1 - 0.023 13.9 0.1 0.049 12.8 0.1 1.5 1 0 0 1 1 1 0 Class II histone deacetylase complex subunits 2 and 3 ERCC3_RAD25_C PF16203.5 ADV25484.1 - 0.029 13.6 0.0 0.051 12.8 0.0 1.3 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase ResIII PF04851.15 ADV25484.1 - 0.041 13.9 0.0 0.12 12.4 0.0 1.8 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Cyt-b5 PF00173.28 ADV25485.1 - 9.9e-11 41.6 0.0 1.7e-10 40.9 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain MotA_ExbB PF01618.16 ADV25485.1 - 0.033 13.9 0.6 0.058 13.1 0.6 1.4 1 0 0 1 1 1 0 MotA/TolQ/ExbB proton channel family RhoGEF PF00621.20 ADV25486.1 - 4.8e-59 199.6 0.4 5.5e-33 114.7 0.0 2.3 2 0 0 2 2 2 2 RhoGEF domain CNH PF00780.22 ADV25486.1 - 2.1e-34 119.4 0.0 8.5e-25 87.9 0.0 2.2 1 1 1 2 2 2 2 CNH domain PH_5 PF15405.6 ADV25486.1 - 5.2e-12 46.0 0.0 1.3e-11 44.8 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain DEP PF00610.21 ADV25486.1 - 0.0011 19.0 0.0 0.0023 17.9 0.0 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PH_13 PF16652.5 ADV25486.1 - 0.0047 16.7 0.0 0.041 13.7 0.0 2.4 2 0 0 2 2 2 1 Pleckstrin homology domain Yos1 PF08571.10 ADV25487.1 - 9.5e-10 38.6 0.0 2.8e-09 37.1 0.0 1.9 1 1 0 1 1 1 1 Yos1-like WD40 PF00400.32 ADV25488.1 - 6.8e-47 156.5 15.7 4.3e-09 36.9 0.1 8.0 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV25488.1 - 1.5e-09 38.1 1.2 0.034 14.4 0.1 5.0 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ADV25488.1 - 4e-09 35.7 9.4 0.21 10.2 0.0 5.4 2 2 2 6 6 6 4 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ADV25488.1 - 3.3e-08 32.9 3.2 0.65 8.9 0.0 4.9 1 1 5 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 ADV25488.1 - 6e-06 25.3 1.5 0.0054 15.5 0.1 3.7 1 1 3 4 4 4 3 Nup133 N terminal like Frtz PF11768.8 ADV25488.1 - 1.8e-05 23.3 0.0 5.8e-05 21.6 0.0 1.7 2 0 0 2 2 2 1 WD repeat-containing and planar cell polarity effector protein Fritz PALB2_WD40 PF16756.5 ADV25488.1 - 0.00049 19.1 1.4 0.0016 17.4 0.0 2.3 2 0 0 2 2 2 1 Partner and localizer of BRCA2 WD40 domain Coatomer_WDAD PF04053.14 ADV25488.1 - 0.00052 19.2 0.1 0.00084 18.5 0.1 1.2 1 0 0 1 1 1 1 Coatomer WD associated region Hira PF07569.11 ADV25488.1 - 0.016 14.9 1.5 4.5 6.9 0.0 3.6 1 1 2 3 3 3 0 TUP1-like enhancer of split HPS3_N PF14761.6 ADV25488.1 - 0.056 13.0 0.0 0.49 9.9 0.0 2.2 1 1 1 2 2 2 0 Hermansky-Pudlak syndrome 3 VID27 PF08553.10 ADV25488.1 - 0.1 11.6 0.0 0.65 9.0 0.0 2.0 2 0 0 2 2 2 0 VID27 C-terminal WD40-like domain Anti-adapt_IraP PF10796.9 ADV25489.1 - 0.24 12.0 3.9 0.61 10.7 2.5 2.4 1 1 1 2 2 2 0 Sigma-S stabilisation anti-adaptor protein Glyco_hydro_79C PF16862.5 ADV25490.1 - 2.3e-15 57.3 0.2 6.6e-15 55.9 0.0 2.0 2 0 0 2 2 2 1 Glycosyl hydrolase family 79 C-terminal beta domain SAM_2 PF07647.17 ADV25491.1 - 2.7e-08 33.8 0.2 6.8e-08 32.5 0.0 1.8 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ADV25491.1 - 9.2e-07 29.2 0.0 2.3e-06 28.0 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF4508 PF14969.6 ADV25491.1 - 0.1 12.8 0.0 0.23 11.7 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4508) TFIIA PF03153.13 ADV25491.1 - 2.7 7.9 7.9 0.35 10.8 1.7 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Mito_carr PF00153.27 ADV25492.1 - 2.7e-65 216.3 6.5 6.7e-23 80.4 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Glyco_hydro_88 PF07470.13 ADV25492.1 - 0.12 11.4 0.0 0.18 10.8 0.0 1.2 1 0 0 1 1 1 0 Glycosyl Hydrolase Family 88 Mito_carr PF00153.27 ADV25493.1 - 3.3e-67 222.5 5.4 7.2e-25 86.8 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Exo5 PF09810.9 ADV25494.1 - 5.3e-57 194.0 0.0 5.8e-35 121.5 0.0 3.1 3 0 0 3 3 3 3 Exonuclease V - a 5' deoxyribonuclease Glucosamine_iso PF01182.20 ADV25495.1 - 9.5e-21 74.7 0.0 1.6e-20 73.9 0.0 1.3 1 1 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Sec23_trunk PF04811.15 ADV25496.1 - 7.5e-45 153.4 0.0 1.3e-44 152.6 0.0 1.3 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 ADV25496.1 - 8.6e-21 73.7 0.1 1.6e-20 72.8 0.1 1.5 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 ADV25496.1 - 6.1e-17 62.1 0.1 1.1e-16 61.3 0.1 1.5 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 ADV25496.1 - 1.3e-15 57.2 1.6 2.6e-15 56.2 1.6 1.6 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 ADV25496.1 - 0.057 13.3 0.0 0.2 11.6 0.0 1.9 1 0 0 1 1 1 0 Gelsolin repeat Aminotran_1_2 PF00155.21 ADV25497.1 - 8e-93 311.5 0.0 9.2e-93 311.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Pkinase PF00069.25 ADV25498.1 - 8.2e-59 199.1 0.0 1.8e-58 198.0 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV25498.1 - 1.4e-25 90.0 0.0 3.5e-25 88.8 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Haspin_kinase PF12330.8 ADV25498.1 - 0.029 13.3 0.0 0.042 12.8 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 ADV25498.1 - 0.1 12.5 0.2 0.16 11.9 0.2 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 ADV25498.1 - 0.17 11.2 0.1 0.31 10.4 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PCNA_N PF00705.18 ADV25500.1 - 1.8e-52 176.3 4.2 6.4e-52 174.6 3.4 2.1 3 0 0 3 3 3 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.15 ADV25500.1 - 2.6e-43 147.2 0.3 4.8e-23 81.7 0.1 3.0 3 0 0 3 3 3 2 Proliferating cell nuclear antigen, C-terminal domain Rad1 PF02144.16 ADV25500.1 - 0.00026 20.2 0.1 0.0032 16.6 0.1 2.3 2 1 0 2 2 2 1 Repair protein Rad1/Rec1/Rad17 Rad9 PF04139.13 ADV25500.1 - 0.00057 19.4 0.0 0.0013 18.2 0.0 1.6 2 0 0 2 2 2 1 Rad9 CDC45 PF02724.14 ADV25500.1 - 0.093 11.0 7.6 0.11 10.8 7.6 1.1 1 0 0 1 1 1 0 CDC45-like protein Hus1 PF04005.12 ADV25500.1 - 0.65 9.0 0.0 0.65 9.0 0.0 2.0 2 0 0 2 2 2 0 Hus1-like protein Trypan_PARP PF05887.11 ADV25500.1 - 0.89 9.5 8.3 1.7 8.7 8.3 1.5 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Merozoite_SPAM PF07133.11 ADV25500.1 - 0.92 9.5 23.1 1.7 8.6 23.1 1.4 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) SLC12 PF03522.15 ADV25500.1 - 0.95 8.4 3.3 1.3 7.9 3.3 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Nop14 PF04147.12 ADV25500.1 - 1.5 6.9 17.6 2.1 6.5 17.6 1.1 1 0 0 1 1 1 0 Nop14-like family SQS_PSY PF00494.19 ADV25501.1 - 3.5e-26 92.3 0.0 5.3e-26 91.7 0.0 1.2 1 0 0 1 1 1 1 Squalene/phytoene synthase DUF383 PF04063.14 ADV25502.1 - 3.9e-50 170.2 0.0 8.9e-50 169.0 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF383) DUF384 PF04064.13 ADV25502.1 - 1.2e-17 63.5 0.3 3.3e-17 62.1 0.3 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF384) SBDS PF01172.18 ADV25504.1 - 4.2e-15 55.6 0.4 4.9e-15 55.4 0.4 1.1 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein Gti1_Pac2 PF09729.9 ADV25504.1 - 0.032 14.3 0.0 0.038 14.1 0.0 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family adh_short PF00106.25 ADV25505.1 - 9e-14 51.4 0.1 1.6e-13 50.6 0.1 1.4 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ADV25505.1 - 2.1e-08 34.0 0.0 2.5e-08 33.8 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Eno-Rase_NADH_b PF12242.8 ADV25505.1 - 0.0093 15.7 0.2 0.018 14.8 0.2 1.4 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase CD45 PF12567.8 ADV25505.1 - 0.1 12.6 0.0 0.18 11.8 0.0 1.3 1 0 0 1 1 1 0 Leukocyte receptor CD45 Antimicrobial15 PF08110.12 ADV25505.1 - 6.5 7.2 6.4 1.1 9.6 0.5 2.6 3 0 0 3 3 3 0 Ocellatin family dUTPase PF00692.19 ADV25506.1 - 1.6e-39 134.5 0.0 2e-39 134.3 0.0 1.1 1 0 0 1 1 1 1 dUTPase Pet127 PF08634.10 ADV25507.1 - 3.5e-103 344.8 0.3 5.5e-103 344.2 0.3 1.3 1 0 0 1 1 1 1 Mitochondrial protein Pet127 Hpt PF01627.23 ADV25510.1 - 7.1e-10 39.0 0.1 7.1e-10 39.0 0.1 2.0 2 0 0 2 2 2 1 Hpt domain GST_C PF00043.25 ADV25510.1 - 0.061 13.6 1.0 0.13 12.5 0.0 2.0 3 0 0 3 3 3 0 Glutathione S-transferase, C-terminal domain BUD22 PF09073.10 ADV25510.1 - 0.37 10.1 16.7 0.45 9.8 16.7 1.1 1 0 0 1 1 1 0 BUD22 GET2 PF08690.10 ADV25510.1 - 1.8 8.1 8.3 2.2 7.8 8.3 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 Presenilin PF01080.17 ADV25510.1 - 4.6 5.9 5.4 4.9 5.8 5.4 1.1 1 0 0 1 1 1 0 Presenilin Cwf_Cwc_15 PF04889.12 ADV25510.1 - 7.5 6.2 18.5 12 5.5 18.5 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein AAA PF00004.29 ADV25511.1 - 1.4e-40 138.8 0.1 4.4e-40 137.2 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 ADV25511.1 - 1.1e-17 63.8 0.1 2e-17 62.9 0.1 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 ADV25511.1 - 3.8e-12 45.8 0.0 9.2e-12 44.6 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 ADV25511.1 - 4e-05 24.1 0.5 0.015 15.7 0.0 2.7 1 1 1 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 ADV25511.1 - 0.00022 21.2 0.1 0.0012 18.8 0.1 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 ADV25511.1 - 0.00038 20.2 0.0 0.00092 19.0 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 ADV25511.1 - 0.00065 20.0 0.7 0.084 13.1 0.7 2.7 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 ADV25511.1 - 0.0046 17.1 0.2 0.018 15.2 0.0 2.2 2 1 0 2 2 2 1 AAA domain PhoH PF02562.16 ADV25511.1 - 0.0062 16.0 0.1 0.066 12.7 0.0 2.3 2 0 0 2 2 2 1 PhoH-like protein AAA_2 PF07724.14 ADV25511.1 - 0.0065 16.6 4.3 0.0089 16.2 0.0 2.9 2 2 0 2 2 2 1 AAA domain (Cdc48 subfamily) Mg_chelatase PF01078.21 ADV25511.1 - 0.009 15.4 0.1 0.039 13.3 0.1 2.0 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI DUF815 PF05673.13 ADV25511.1 - 0.022 14.0 0.0 0.054 12.6 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF815) IstB_IS21 PF01695.17 ADV25511.1 - 0.025 14.3 0.0 0.055 13.2 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein RNA_helicase PF00910.22 ADV25511.1 - 0.096 13.1 0.0 0.28 11.6 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_24 PF13479.6 ADV25511.1 - 0.23 11.2 2.4 0.23 11.1 0.1 2.3 2 1 0 2 2 2 0 AAA domain DUF2347 PF09804.9 ADV25512.1 - 1.7e-62 211.5 0.0 2.5e-62 211.0 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2347) SPA PF08616.10 ADV25512.1 - 0.00075 19.4 0.0 0.0018 18.2 0.0 1.6 1 0 0 1 1 1 1 Stabilization of polarity axis Fungal_trans PF04082.18 ADV25513.1 - 9.6e-11 41.2 1.2 2e-10 40.2 1.2 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ADV25513.1 - 4.4e-07 29.9 11.6 4.4e-07 29.9 11.6 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain NCD3G PF07562.14 ADV25514.1 - 0.13 12.2 0.5 0.32 11.0 0.5 1.5 1 0 0 1 1 1 0 Nine Cysteines Domain of family 3 GPCR Vfa1 PF08432.10 ADV25514.1 - 0.59 10.4 10.8 2 8.7 9.7 2.4 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 VP9 PF09625.10 ADV25515.1 - 0.085 13.0 0.2 0.15 12.2 0.2 1.3 1 0 0 1 1 1 0 VP9 protein DUF1043 PF06295.12 ADV25515.1 - 1 9.4 4.0 2 8.4 4.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) PIP5K PF01504.18 ADV25516.1 - 4.6e-47 160.5 3.2 7e-46 156.7 0.1 3.0 2 1 0 2 2 2 1 Phosphatidylinositol-4-phosphate 5-Kinase Cep57_CLD_2 PF14197.6 ADV25516.1 - 0.022 14.9 0.5 0.067 13.3 0.5 1.8 1 0 0 1 1 1 0 Centrosome localisation domain of PPC89 zf-C2H2 PF00096.26 ADV25517.1 - 0.0031 17.9 7.9 1.1 9.9 0.3 3.7 3 0 0 3 3 3 2 Zinc finger, C2H2 type DUF2218 PF09981.9 ADV25517.1 - 0.031 14.7 0.0 0.11 12.8 0.0 2.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2218) DUF3629 PF12302.8 ADV25517.1 - 0.063 12.7 2.3 3 7.2 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3629) zf-C2H2_4 PF13894.6 ADV25517.1 - 0.31 12.0 3.1 1.1 10.2 0.2 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger FOXP-CC PF16159.5 ADV25517.1 - 1.4 9.6 23.6 0.12 13.0 3.4 4.4 3 1 2 5 5 5 0 FOXP coiled-coil domain Aa_trans PF01490.18 ADV25518.1 - 4.5e-23 81.6 13.4 5.9e-23 81.2 13.4 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Spore_permease PF03845.13 ADV25518.1 - 0.011 14.5 5.3 0.016 14.0 5.3 1.3 1 0 0 1 1 1 0 Spore germination protein DUF2370 PF10176.9 ADV25519.1 - 7.1e-77 258.1 0.0 1.1e-76 257.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2370) Auxin_repressed PF05564.12 ADV25519.1 - 1 10.1 6.5 3.1 8.5 0.2 3.0 3 0 0 3 3 3 0 Dormancy/auxin associated protein Esterase PF00756.20 ADV25520.1 - 2.4e-43 148.6 0.0 2.9e-43 148.3 0.0 1.0 1 0 0 1 1 1 1 Putative esterase Hydrolase_4 PF12146.8 ADV25520.1 - 3.8e-05 23.1 0.0 0.00019 20.8 0.0 1.6 1 1 1 2 2 2 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 ADV25520.1 - 0.00019 21.0 0.0 0.00025 20.6 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 ADV25520.1 - 0.00028 20.8 0.0 0.11 12.4 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Chlorophyllase2 PF12740.7 ADV25520.1 - 0.0023 16.9 0.0 0.0043 16.0 0.0 1.4 1 1 0 1 1 1 1 Chlorophyllase enzyme Pkinase PF00069.25 ADV25521.1 - 2.9e-49 167.8 0.0 2.7e-31 108.9 0.0 4.1 3 1 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 ADV25521.1 - 2.2e-26 92.7 0.0 1.4e-17 63.9 0.0 2.5 2 0 0 2 2 2 2 Protein tyrosine kinase HGTP_anticodon2 PF12745.7 ADV25521.1 - 4.2e-17 62.5 0.1 4.2e-17 62.5 0.1 3.1 3 0 0 3 3 3 1 Anticodon binding domain of tRNAs RWD PF05773.22 ADV25521.1 - 3.1e-15 56.5 0.1 7.5e-15 55.2 0.1 1.7 1 0 0 1 1 1 1 RWD domain tRNA-synt_His PF13393.6 ADV25521.1 - 2.7e-07 30.2 1.8 3.3e-07 29.9 0.0 2.1 3 0 0 3 3 3 1 Histidyl-tRNA synthetase APH PF01636.23 ADV25521.1 - 3.4e-05 23.9 0.4 9.6e-05 22.4 0.0 1.9 2 0 0 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 ADV25521.1 - 0.0022 17.6 0.8 0.0063 16.1 0.0 2.1 3 0 0 3 3 3 1 RIO1 family FTA2 PF13095.6 ADV25521.1 - 0.0025 17.5 0.1 1.3 8.6 0.0 2.4 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 ADV25521.1 - 0.011 14.7 0.0 0.02 13.8 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 ADV25521.1 - 0.02 14.2 0.0 0.12 11.7 0.0 2.2 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ADV25521.1 - 0.03 13.6 2.6 0.032 13.6 0.0 2.1 2 0 0 2 2 2 0 Kinase-like NOA36 PF06524.12 ADV25521.1 - 7.4 5.8 7.7 13 5.0 7.7 1.3 1 0 0 1 1 1 0 NOA36 protein Rad51 PF08423.11 ADV25522.1 - 6.3e-107 356.6 0.0 7.9e-107 356.3 0.0 1.1 1 0 0 1 1 1 1 Rad51 RecA PF00154.21 ADV25522.1 - 4.8e-12 45.9 0.1 6.9e-12 45.4 0.1 1.2 1 0 0 1 1 1 1 recA bacterial DNA recombination protein AAA_25 PF13481.6 ADV25522.1 - 2e-08 34.0 0.0 3e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 ADV25522.1 - 2.2e-06 27.2 0.0 7.9e-06 25.4 0.0 1.9 1 1 0 1 1 1 1 KaiC AAA_22 PF13401.6 ADV25522.1 - 0.0022 18.3 0.0 0.0041 17.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain DnaB_C PF03796.15 ADV25522.1 - 0.0066 15.8 0.3 0.032 13.6 0.2 1.9 1 1 1 2 2 2 1 DnaB-like helicase C terminal domain AAA_24 PF13479.6 ADV25522.1 - 0.017 14.9 0.0 0.074 12.8 0.0 1.9 1 1 0 1 1 1 0 AAA domain TniB PF05621.11 ADV25522.1 - 0.022 14.1 0.2 2 7.8 0.2 2.4 2 1 0 2 2 2 0 Bacterial TniB protein HHH_5 PF14520.6 ADV25522.1 - 0.13 12.9 3.3 0.11 13.1 1.1 2.0 2 0 0 2 2 2 0 Helix-hairpin-helix domain RNA_pol_A_CTD PF03118.15 ADV25522.1 - 0.14 11.9 0.2 0.3 10.9 0.2 1.4 1 0 0 1 1 1 0 Bacterial RNA polymerase, alpha chain C terminal domain CobS_N PF12556.8 ADV25522.1 - 0.2 11.4 0.2 0.5 10.1 0.2 1.7 1 0 0 1 1 1 0 Cobaltochelatase CobS subunit N terminal DUF155 PF02582.14 ADV25523.1 - 4.9e-55 186.3 0.2 7.3e-55 185.8 0.2 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 Nuc_N PF14448.6 ADV25523.1 - 0.1 12.4 0.1 9 6.2 0.0 2.4 2 0 0 2 2 2 0 Nuclease N terminal CCD PF07860.11 ADV25524.1 - 0.037 14.1 0.8 0.091 12.8 0.1 1.8 2 0 0 2 2 2 0 WisP family C-Terminal Region SHE3 PF17078.5 ADV25525.1 - 0.00025 20.8 31.5 0.0026 17.5 31.5 2.2 1 1 0 1 1 1 1 SWI5-dependent HO expression protein 3 LMBR1 PF04791.16 ADV25525.1 - 0.28 10.0 13.6 0.45 9.3 13.6 1.4 1 0 0 1 1 1 0 LMBR1-like membrane protein Golgin_A5 PF09787.9 ADV25525.1 - 0.39 10.1 48.4 0.037 13.5 17.7 3.2 2 1 1 3 3 3 0 Golgin subfamily A member 5 DUF2087 PF09860.9 ADV25525.1 - 0.4 10.9 4.6 8.1 6.7 0.0 2.9 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2087) TMP_2 PF06791.13 ADV25525.1 - 0.58 9.8 3.8 0.51 10.0 0.4 2.2 2 0 0 2 2 2 0 Prophage tail length tape measure protein Taxilin PF09728.9 ADV25525.1 - 1.2 8.3 48.3 0.21 10.8 39.9 2.5 2 1 1 3 3 3 0 Myosin-like coiled-coil protein Spc7 PF08317.11 ADV25525.1 - 1.3 7.8 51.1 0.053 12.4 16.8 3.6 2 1 2 4 4 4 0 Spc7 kinetochore protein HAUS6_N PF14661.6 ADV25525.1 - 3.5 7.1 30.6 1.3 8.6 12.0 2.4 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus DUF3450 PF11932.8 ADV25525.1 - 5.1 6.3 42.4 1.2 8.4 8.4 3.7 2 1 2 4 4 4 0 Protein of unknown function (DUF3450) GFO_IDH_MocA PF01408.22 ADV25526.1 - 5.7e-18 65.9 0.0 1.4e-17 64.6 0.0 1.7 1 1 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ADV25526.1 - 4.3e-05 23.5 0.0 9.1e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain Zn_clus PF00172.18 ADV25527.1 - 0.00093 19.3 11.5 0.0017 18.4 11.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain BcrAD_BadFG PF01869.20 ADV25528.1 - 0.0023 17.5 0.0 0.011 15.2 0.0 1.9 2 0 0 2 2 2 1 BadF/BadG/BcrA/BcrD ATPase family Amidohydro_1 PF01979.20 ADV25529.1 - 5.3e-15 55.6 0.0 2.2e-14 53.5 0.0 2.0 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 ADV25529.1 - 4.6e-05 23.1 0.0 0.008 15.7 0.0 2.5 2 1 0 2 2 2 2 Amidohydrolase family DUF687 PF05095.12 ADV25529.1 - 0.24 9.8 0.0 0.34 9.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF687) MFS_1 PF07690.16 ADV25530.1 - 2.9e-17 62.7 39.2 2.9e-17 62.7 39.2 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.16 ADV25530.1 - 8e-15 54.9 7.6 8e-15 54.9 7.6 2.8 3 0 0 3 3 3 1 Ion channel regulatory protein UNC-93 RNA_polI_A34 PF08208.11 ADV25531.1 - 4.8 7.2 21.2 9.6 6.2 21.2 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 ORC4_C PF14629.6 ADV25532.1 - 4.3e-33 114.5 0.0 6.6e-33 113.9 0.0 1.3 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 4 C-terminus AAA_16 PF13191.6 ADV25532.1 - 2.3e-12 47.7 0.0 1.1e-11 45.5 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 ADV25532.1 - 0.00091 19.5 0.0 0.0019 18.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 ADV25532.1 - 0.088 13.2 0.0 0.46 10.9 0.0 2.0 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 ADV25532.1 - 0.15 11.9 0.0 0.27 11.1 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_7 PF12775.7 ADV25532.1 - 0.2 11.1 0.0 0.41 10.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region MCM PF00493.23 ADV25533.1 - 8.6e-99 329.2 0.0 1.5e-98 328.4 0.0 1.4 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 ADV25533.1 - 1.5e-38 131.4 0.2 2.8e-38 130.6 0.2 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 ADV25533.1 - 5.5e-30 103.6 3.0 1.2e-29 102.5 3.0 1.6 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 ADV25533.1 - 1e-17 64.6 0.2 3.2e-17 63.0 0.1 2.0 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.21 ADV25533.1 - 6.7e-08 32.2 0.0 9.4e-05 21.9 0.0 2.3 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 ADV25533.1 - 8.8e-08 32.2 0.0 3.2e-07 30.4 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 ADV25533.1 - 3.5e-05 23.7 0.0 0.0013 18.6 0.0 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 ADV25533.1 - 0.0012 18.6 0.4 1.1 9.0 0.0 3.2 4 0 0 4 4 4 2 Sigma-54 interaction domain AAA_16 PF13191.6 ADV25533.1 - 0.041 14.3 1.3 0.45 10.9 0.1 3.2 2 1 0 2 2 2 0 AAA ATPase domain ETC_C1_NDUFA4 PF04800.12 ADV25534.1 - 4.6e-33 113.3 0.1 5.9e-33 113.0 0.1 1.1 1 0 0 1 1 1 1 ETC complex I subunit conserved region Aconitase PF00330.20 ADV25536.1 - 4.4e-153 510.6 0.0 5.6e-153 510.3 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 ADV25536.1 - 6.6e-36 123.5 0.0 1.1e-35 122.8 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain DUF521 PF04412.13 ADV25536.1 - 0.014 14.1 0.0 0.067 11.9 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF521) RPN2_C PF18004.1 ADV25537.1 - 1.5e-35 122.5 2.1 5.8e-33 114.1 2.1 2.3 2 0 0 2 2 2 2 26S proteasome regulatory subunit RPN2 C-terminal domain PC_rep PF01851.22 ADV25537.1 - 6.9e-28 95.6 23.9 5.4e-08 32.9 0.0 8.7 8 0 0 8 8 8 7 Proteasome/cyclosome repeat HEAT_2 PF13646.6 ADV25537.1 - 7.9e-20 71.1 4.8 4.7e-14 52.5 0.0 5.6 5 1 2 7 7 7 3 HEAT repeats HEAT PF02985.22 ADV25537.1 - 8.8e-05 22.4 0.2 3.3 8.2 0.1 5.0 5 0 0 5 5 5 1 HEAT repeat HEAT_EZ PF13513.6 ADV25537.1 - 0.00057 20.3 1.1 1.1 9.9 0.1 5.0 3 1 2 5 5 5 2 HEAT-like repeat Hydrolase PF00702.26 ADV25538.1 - 3.3e-12 47.1 0.0 4.5e-12 46.7 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 ADV25538.1 - 1.3e-08 35.2 0.0 2.3e-08 34.3 0.0 1.5 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ADV25538.1 - 1.8e-05 24.7 0.0 3e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Transketolase_N PF00456.21 ADV25539.1 - 1.3e-132 441.8 0.1 1.8e-132 441.4 0.1 1.2 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 ADV25539.1 - 3.9e-36 124.4 0.0 6.7e-36 123.6 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 ADV25539.1 - 1.4e-09 37.9 0.0 2.8e-09 36.9 0.0 1.5 1 0 0 1 1 1 1 Transketolase, C-terminal domain TPP_enzyme_C PF02775.21 ADV25539.1 - 2.4e-05 24.1 1.1 8.9e-05 22.3 1.1 2.0 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DXP_synthase_N PF13292.6 ADV25539.1 - 0.00012 21.4 0.0 0.00059 19.1 0.0 1.9 1 1 0 2 2 2 1 1-deoxy-D-xylulose-5-phosphate synthase Alba PF01918.21 ADV25539.1 - 0.0076 16.0 0.0 0.018 14.8 0.0 1.6 1 0 0 1 1 1 1 Alba E1_dh PF00676.20 ADV25539.1 - 0.014 14.4 0.1 0.024 13.6 0.1 1.3 1 0 0 1 1 1 0 Dehydrogenase E1 component ADH_N PF08240.12 ADV25541.1 - 6.8e-29 99.9 1.4 1.2e-28 99.1 1.4 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ADV25541.1 - 5.5e-12 45.8 0.0 3.9e-09 36.6 0.0 2.7 2 0 0 2 2 2 2 Zinc-binding dehydrogenase TrkA_N PF02254.18 ADV25541.1 - 0.013 15.7 0.0 0.023 15.0 0.0 1.3 1 0 0 1 1 1 0 TrkA-N domain AlaDh_PNT_C PF01262.21 ADV25541.1 - 0.063 12.6 0.0 0.1 11.8 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain ADH_N PF08240.12 ADV25542.1 - 9.6e-26 89.8 3.1 1.9e-25 88.8 3.1 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ADV25542.1 - 8.7e-20 71.0 0.0 1.4e-19 70.3 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 ADV25542.1 - 0.00013 21.5 0.0 0.00027 20.5 0.0 1.5 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 ADV25542.1 - 0.00017 21.0 0.1 0.00028 20.2 0.1 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 ADV25542.1 - 0.00078 18.8 0.0 0.0012 18.2 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TrkA_N PF02254.18 ADV25542.1 - 0.037 14.3 0.0 0.066 13.5 0.0 1.4 1 0 0 1 1 1 0 TrkA-N domain ADH_N_2 PF16884.5 ADV25542.1 - 0.044 13.7 0.0 0.098 12.6 0.0 1.5 1 0 0 1 1 1 0 N-terminal domain of oxidoreductase Pro_dh PF01619.18 ADV25543.1 - 1.6e-16 60.7 0.0 4.5e-16 59.3 0.0 1.7 2 1 0 2 2 2 1 Proline dehydrogenase TPM_phosphatase PF04536.14 ADV25543.1 - 0.0011 19.1 0.0 0.002 18.3 0.0 1.4 1 0 0 1 1 1 1 TPM domain Zn_clus PF00172.18 ADV25544.1 - 8e-05 22.7 4.9 0.00013 22.0 4.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ribonuc_L-PSP PF01042.21 ADV25545.1 - 3.4e-06 27.1 0.0 4.5e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 Endoribonuclease L-PSP Helicase_C PF00271.31 ADV25546.1 - 9.7e-20 71.0 0.1 2.8e-19 69.5 0.1 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 ADV25546.1 - 3.6e-18 65.9 0.0 4.2e-17 62.5 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 ADV25546.1 - 7.8e-18 65.1 0.0 1.6e-17 64.0 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit NARP1 PF12569.8 ADV25546.1 - 1.1 8.1 6.5 2.5 6.9 6.5 1.5 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Fib_alpha PF08702.10 ADV25547.1 - 0.46 10.7 5.6 0.54 10.4 4.1 1.9 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family RasGEF PF00617.19 ADV25548.1 - 1.6e-47 162.0 0.0 3.2e-47 161.0 0.0 1.5 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ADV25548.1 - 8.7e-22 77.4 0.1 5.4e-21 74.8 0.1 2.5 3 0 0 3 3 3 1 RasGEF N-terminal motif SH3_2 PF07653.17 ADV25548.1 - 1e-06 28.3 0.0 2e-06 27.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ADV25548.1 - 6e-06 25.8 0.0 1.7e-05 24.3 0.0 1.8 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ADV25548.1 - 7.8e-06 25.7 0.0 1.7e-05 24.6 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain COG4 PF08318.12 ADV25550.1 - 1.4e-88 297.2 0.0 2.1e-88 296.7 0.0 1.3 1 0 0 1 1 1 1 COG4 transport protein RINT1_TIP1 PF04437.13 ADV25550.1 - 0.00033 19.7 0.2 0.013 14.5 0.0 2.3 2 0 0 2 2 2 2 RINT-1 / TIP-1 family ORC6 PF05460.13 ADV25551.1 - 0.24 10.7 0.0 0.24 10.7 0.0 2.3 2 1 0 2 2 2 0 Origin recognition complex subunit 6 (ORC6) PRIMA1 PF16101.5 ADV25551.1 - 0.33 11.0 4.1 0.31 11.1 0.2 2.2 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 HSP90 PF00183.18 ADV25552.1 - 3.7e-228 758.6 22.8 4.8e-228 758.2 22.8 1.1 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 ADV25552.1 - 1.2e-14 54.8 0.1 2.5e-14 53.8 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 ADV25552.1 - 1.5e-11 44.3 0.1 1.5e-11 44.3 0.1 2.0 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Cofac_haem_bdg PF04187.13 ADV25552.1 - 0.068 13.1 0.0 0.21 11.6 0.0 1.8 1 0 0 1 1 1 0 Haem-binding uptake, Tiki superfamily, ChaN DUF2052 PF09747.9 ADV25552.1 - 0.46 10.6 10.8 0.17 12.0 6.6 2.1 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) ArAE_2 PF10334.9 ADV25553.1 - 2.9e-46 158.2 0.0 1.1e-43 149.7 0.0 3.0 3 0 0 3 3 3 2 Aromatic acid exporter family member 2 ArAE_2_N PF10337.9 ADV25553.1 - 6.2e-16 58.5 0.9 2.9e-10 39.8 0.1 2.9 3 0 0 3 3 3 2 Putative ER transporter, 6TM, N-terminal FUSC_2 PF13515.6 ADV25553.1 - 2.4e-09 37.4 11.5 2.4e-09 37.4 11.5 2.2 2 0 0 2 2 2 1 Fusaric acid resistance protein-like RNA_pol_Rpc4 PF05132.14 ADV25553.1 - 0.034 14.6 1.3 4.5 7.7 0.3 2.5 2 1 0 2 2 2 0 RNA polymerase III RPC4 RSN1_7TM PF02714.15 ADV25554.1 - 2.5e-29 102.4 16.3 2.5e-29 102.4 16.3 1.7 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 ADV25554.1 - 6.9e-16 58.4 2.2 6.9e-16 58.4 2.2 2.5 3 0 0 3 3 3 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 ADV25554.1 - 3.5e-13 50.2 0.0 3.9e-08 33.7 0.0 2.6 1 1 1 2 2 2 2 Cytosolic domain of 10TM putative phosphate transporter TCTP PF00838.17 ADV25556.1 - 1.2e-74 250.1 0.5 1.4e-74 250.0 0.5 1.0 1 0 0 1 1 1 1 Translationally controlled tumour protein RcbX PF02341.15 ADV25556.1 - 0.05 13.9 0.0 0.082 13.2 0.0 1.4 1 0 0 1 1 1 0 RbcX protein DUF4286 PF14114.6 ADV25556.1 - 0.12 12.9 0.4 0.22 12.0 0.3 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4286) 2OG-FeII_Oxy_2 PF13532.6 ADV25557.1 - 1.7e-32 113.2 0.0 4.3e-31 108.6 0.0 2.1 2 0 0 2 2 2 2 2OG-Fe(II) oxygenase superfamily Pol_alpha_B_N PF08418.10 ADV25558.1 - 4.8e-50 170.8 0.0 7.9e-50 170.1 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase alpha subunit B N-terminal DNA_pol_E_B PF04042.16 ADV25558.1 - 1.2e-31 109.8 1.8 2.2e-31 108.9 1.8 1.5 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Hamartin PF04388.12 ADV25558.1 - 0.23 10.1 2.5 0.37 9.4 2.5 1.3 1 0 0 1 1 1 0 Hamartin protein Pkinase PF00069.25 ADV25559.1 - 1.2e-49 169.0 0.0 1.8e-48 165.2 0.0 2.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV25559.1 - 2e-20 73.2 0.0 4.8e-20 71.9 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase MRFAP1 PF15155.6 ADV25559.1 - 0.034 14.7 3.0 0.081 13.4 3.0 1.6 1 0 0 1 1 1 0 MORF4 family-associated protein1 Collagen PF01391.18 ADV25559.1 - 0.14 12.0 1.8 0.36 10.6 1.8 1.7 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) DRY_EERY PF09750.9 ADV25561.1 - 4.7 7.5 9.5 0.61 10.3 4.0 2.3 1 1 2 3 3 3 0 Alternative splicing regulator HA2 PF04408.23 ADV25563.1 - 4e-16 59.2 0.0 1.2e-15 57.7 0.0 1.9 1 0 0 1 1 1 1 Helicase associated domain (HA2) dsrm PF00035.26 ADV25563.1 - 1e-15 58.2 0.1 4.1e-07 30.6 0.1 2.7 2 0 0 2 2 2 2 Double-stranded RNA binding motif Helicase_C PF00271.31 ADV25563.1 - 6.1e-15 55.5 0.0 1.5e-14 54.3 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 ADV25563.1 - 4.5e-08 33.1 0.3 1.3e-07 31.6 0.1 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_19 PF13245.6 ADV25563.1 - 0.00025 21.4 0.1 0.00056 20.3 0.1 1.5 1 0 0 1 1 1 1 AAA domain EI24 PF07264.11 ADV25564.1 - 7.9e-07 29.5 10.1 1.9e-06 28.3 10.1 1.7 1 1 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) Tautomerase_3 PF14832.6 ADV25566.1 - 0.0047 17.2 0.0 0.0051 17.0 0.0 1.0 1 0 0 1 1 1 1 Putative oxalocrotonate tautomerase enzyme HMG_box PF00505.19 ADV25567.1 - 6.8e-06 26.4 0.3 6.8e-06 26.4 0.3 2.3 2 0 0 2 2 2 1 HMG (high mobility group) box Rrn6 PF10214.9 ADV25567.1 - 0.029 12.9 4.7 0.045 12.2 4.7 1.2 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor MFS_1 PF07690.16 ADV25568.1 - 6.9e-32 110.7 17.0 5.6e-31 107.7 16.8 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily UNC-93 PF05978.16 ADV25568.1 - 0.0038 16.9 5.8 0.0056 16.4 4.3 2.0 2 0 0 2 2 2 1 Ion channel regulatory protein UNC-93 LapA_dom PF06305.11 ADV25568.1 - 0.23 11.3 1.7 17 5.3 0.1 3.6 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain DUF1772 PF08592.11 ADV25568.1 - 2.6 8.4 10.2 1.6 9.1 2.9 3.4 2 2 0 3 3 3 0 Domain of unknown function (DUF1772) DEAD PF00270.29 ADV25569.1 - 3.5e-40 137.6 0.0 5.8e-40 136.9 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ADV25569.1 - 1.8e-28 99.1 0.0 5e-28 97.7 0.0 1.8 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 ADV25569.1 - 0.0041 17.1 0.0 0.011 15.7 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CDC45 PF02724.14 ADV25569.1 - 0.0072 14.7 2.6 0.0092 14.3 2.6 1.2 1 0 0 1 1 1 1 CDC45-like protein Nop14 PF04147.12 ADV25569.1 - 0.12 10.6 6.2 0.16 10.2 6.2 1.2 1 0 0 1 1 1 0 Nop14-like family DUF4611 PF15387.6 ADV25569.1 - 2.9 8.2 10.8 8 6.8 10.8 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) Astro_capsid_p PF12226.8 ADV25569.1 - 3.9 6.5 9.3 6 5.9 9.3 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Sigma70_ner PF04546.13 ADV25569.1 - 6.5 6.6 11.0 13 5.6 11.0 1.4 1 0 0 1 1 1 0 Sigma-70, non-essential region B12D PF06522.11 ADV25570.1 - 0.049 13.4 0.0 0.087 12.6 0.0 1.4 1 0 0 1 1 1 0 NADH-ubiquinone reductase complex 1 MLRQ subunit HSP70 PF00012.20 ADV25571.1 - 4e-166 553.7 0.7 4e-166 553.7 0.7 2.1 1 1 1 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.13 ADV25571.1 - 6e-12 45.0 0.0 1.6e-11 43.6 0.0 1.6 2 0 0 2 2 2 1 MreB/Mbl protein Alb1 PF09135.11 ADV25573.1 - 1.1 10.2 6.9 2.9 8.8 6.9 1.7 1 0 0 1 1 1 0 Alb1 HEAT PF02985.22 ADV25574.1 - 1.6e-37 124.3 15.9 0.00083 19.4 0.0 13.8 14 0 0 14 14 14 10 HEAT repeat HEAT_2 PF13646.6 ADV25574.1 - 3.9e-28 97.7 13.0 2.9e-09 37.2 0.0 7.9 2 2 6 8 8 8 8 HEAT repeats HEAT_EZ PF13513.6 ADV25574.1 - 4e-16 59.1 9.5 0.0014 19.1 0.0 8.1 7 2 2 9 9 9 4 HEAT-like repeat Vac14_Fab1_bd PF12755.7 ADV25574.1 - 2.9e-11 43.8 0.3 0.052 14.2 0.0 7.1 2 2 6 8 8 8 4 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 ADV25574.1 - 1.9e-09 37.8 2.0 0.35 10.9 0.0 5.2 4 2 2 6 6 6 3 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 ADV25574.1 - 1.9e-05 23.4 0.7 0.064 11.8 0.0 3.4 2 1 0 3 3 3 2 Adaptin N terminal region Arm PF00514.23 ADV25574.1 - 0.0032 17.4 2.5 28 4.9 0.0 5.9 6 0 0 6 6 6 0 Armadillo/beta-catenin-like repeat IFRD PF05004.13 ADV25574.1 - 0.017 14.2 0.7 4.7 6.2 0.0 3.8 3 2 0 3 3 3 0 Interferon-related developmental regulator (IFRD) HEAT_PBS PF03130.16 ADV25574.1 - 0.03 15.0 4.1 2.4 9.1 0.2 5.1 6 0 0 6 6 6 0 PBS lyase HEAT-like repeat RTP1_C1 PF10363.9 ADV25574.1 - 0.071 13.3 4.5 26 5.0 0.1 4.3 4 1 0 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 Suc_Fer-like PF06999.12 ADV25575.1 - 1.9e-45 155.2 0.0 2.5e-45 154.8 0.0 1.2 1 0 0 1 1 1 1 Sucrase/ferredoxin-like Ribosomal_L32e PF01655.18 ADV25577.1 - 1.1e-50 170.5 0.7 1.3e-50 170.3 0.7 1.0 1 0 0 1 1 1 1 Ribosomal protein L32 CS PF04969.16 ADV25578.1 - 1.8e-16 60.9 0.1 3.1e-16 60.1 0.1 1.4 1 0 0 1 1 1 1 CS domain DUF1770 PF08589.10 ADV25578.1 - 0.038 14.9 2.9 0.69 10.9 0.2 2.2 2 0 0 2 2 2 0 Fungal protein of unknown function (DUF1770) VRR_NUC PF08774.11 ADV25579.1 - 2.9e-28 98.1 0.0 7.2e-28 96.8 0.0 1.7 1 0 0 1 1 1 1 VRR-NUC domain SGS PF05002.15 ADV25580.1 - 2.5e-30 104.4 0.2 4.2e-30 103.7 0.2 1.4 1 0 0 1 1 1 1 SGS domain CS PF04969.16 ADV25580.1 - 1.5e-08 35.6 0.0 2.5e-08 34.8 0.0 1.4 1 0 0 1 1 1 1 CS domain Ribosomal_L13 PF00572.18 ADV25581.1 - 3.6e-10 40.2 0.1 2.6e-08 34.2 0.1 2.2 1 1 0 1 1 1 1 Ribosomal protein L13 DUF1629 PF07791.11 ADV25581.1 - 0.028 14.6 0.0 0.055 13.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1629) Methyltransf_PK PF05891.12 ADV25583.1 - 1.3e-45 155.6 0.0 2.9e-25 89.1 0.0 2.9 2 1 0 2 2 2 2 AdoMet dependent proline di-methyltransferase Methyltransf_25 PF13649.6 ADV25583.1 - 0.00011 22.8 0.0 0.54 11.0 0.0 3.5 4 0 0 4 4 4 2 Methyltransferase domain Methyltransf_23 PF13489.6 ADV25583.1 - 0.0063 16.4 0.0 0.029 14.2 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 ADV25583.1 - 0.02 15.6 0.0 0.57 11.0 0.0 2.8 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.12 ADV25583.1 - 0.021 15.5 0.0 20 5.9 0.0 3.3 2 1 1 3 3 3 0 Methyltransferase domain Sulf_transp PF04143.14 ADV25584.1 - 2.2e-11 43.9 18.0 2.8e-08 33.7 9.3 3.1 3 0 0 3 3 3 2 Sulphur transport Thioredoxin PF00085.20 ADV25587.1 - 2.6e-44 149.4 0.2 1e-23 83.3 0.0 4.4 5 1 0 5 5 5 3 Thioredoxin Thioredoxin_6 PF13848.6 ADV25587.1 - 2.3e-40 138.5 0.0 4.1e-30 105.1 0.0 3.2 2 1 1 3 3 3 3 Thioredoxin-like domain Thioredoxin_2 PF13098.6 ADV25587.1 - 7.8e-05 23.1 0.0 0.16 12.5 0.0 3.6 3 0 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 ADV25587.1 - 0.0014 18.9 0.0 0.33 11.3 0.0 3.8 4 0 0 4 4 4 1 Thioredoxin-like Thioredoxin_7 PF13899.6 ADV25587.1 - 0.017 15.3 0.0 0.1 12.8 0.0 2.3 2 0 0 2 2 2 0 Thioredoxin-like FTR1 PF03239.14 ADV25588.1 - 1.4e-67 228.1 6.0 1.9e-67 227.6 6.0 1.2 1 0 0 1 1 1 1 Iron permease FTR1 family Ctr PF04145.15 ADV25588.1 - 0.00026 21.6 1.2 0.016 15.8 0.1 2.7 2 1 1 3 3 3 1 Ctr copper transporter family DUF2852 PF11014.8 ADV25588.1 - 0.0079 16.4 0.6 0.21 11.8 0.0 2.9 3 0 0 3 3 3 1 Protein of unknown function (DUF2852) DUF4834 PF16118.5 ADV25588.1 - 0.039 14.9 0.4 5.3 8.1 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) DUF4131 PF13567.6 ADV25588.1 - 0.28 10.8 5.5 0.66 9.6 0.3 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4131) DUF2721 PF11026.8 ADV25588.1 - 5.9 6.8 8.0 0.37 10.7 0.5 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF2721) DUF4763 PF15960.5 ADV25589.1 - 0.65 9.3 8.0 0.029 13.7 0.8 2.2 1 1 0 2 2 2 0 Domain of unknown function (DUF4763) Glycos_transf_1 PF00534.20 ADV25590.1 - 3e-27 95.2 0.0 1.1e-26 93.4 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ADV25590.1 - 1.1e-22 80.9 0.0 2.1e-22 80.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 ADV25590.1 - 1.3e-15 57.8 0.0 2.5e-15 56.9 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 ADV25590.1 - 1.1e-06 29.2 0.0 2.5e-06 28.0 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.6 ADV25590.1 - 0.0028 18.0 0.0 0.013 15.9 0.0 1.9 1 1 0 1 1 1 1 Glycosyl transferases group 1 DAO PF01266.24 ADV25591.1 - 1.6e-37 129.9 0.1 2e-37 129.6 0.1 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 ADV25591.1 - 0.00013 22.1 0.0 0.00063 19.9 0.0 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 ADV25591.1 - 0.059 13.4 0.2 0.28 11.2 0.0 2.1 2 0 0 2 2 2 0 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 ADV25591.1 - 0.064 12.3 0.1 0.34 9.9 0.0 2.0 2 0 0 2 2 2 0 FAD binding domain Thi4 PF01946.17 ADV25591.1 - 0.14 11.4 0.0 0.24 10.6 0.0 1.3 1 0 0 1 1 1 0 Thi4 family Fungal_trans_2 PF11951.8 ADV25592.1 - 4.6e-21 75.1 3.8 4.6e-21 75.1 3.8 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ADV25592.1 - 2.5e-09 37.1 7.1 5.1e-09 36.1 7.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Transp_cyt_pur PF02133.15 ADV25593.1 - 1.1e-89 301.2 43.7 1.3e-89 301.0 43.7 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Metallophos PF00149.28 ADV25594.1 - 1.1e-09 39.1 1.2 1.1e-09 39.1 1.2 1.7 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase TauD PF02668.16 ADV25595.1 - 2.9e-31 109.2 0.0 4.9e-21 75.7 0.0 2.1 2 0 0 2 2 2 2 Taurine catabolism dioxygenase TauD, TfdA family CLU PF13236.6 ADV25596.1 - 5.8e-71 238.8 0.0 1e-70 238.0 0.0 1.5 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.7 ADV25596.1 - 1.5e-47 161.9 0.0 4.3e-47 160.4 0.0 1.9 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit 135 TPR_12 PF13424.6 ADV25596.1 - 1.2e-21 76.8 2.8 2.8e-10 40.3 0.0 4.7 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.6 ADV25596.1 - 2.1e-08 33.7 10.7 0.1 12.5 0.0 5.8 6 0 0 6 6 6 4 Tetratricopeptide repeat DUF727 PF05303.12 ADV25596.1 - 0.063 13.3 0.0 0.23 11.5 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF727) Syntaxin-18_N PF10496.9 ADV25597.1 - 0.031 14.5 0.3 0.031 14.5 0.3 1.9 2 0 0 2 2 2 0 SNARE-complex protein Syntaxin-18 N-terminus UNC119_bdg PF15435.6 ADV25597.1 - 0.034 13.7 0.0 0.076 12.6 0.0 1.5 1 0 0 1 1 1 0 UNC119-binding protein C5orf30 homologue bZIP_2 PF07716.15 ADV25597.1 - 0.4 10.8 6.0 0.83 9.8 6.0 1.5 1 0 0 1 1 1 0 Basic region leucine zipper Cu-oxidase_2 PF07731.14 ADV25598.1 - 1.9e-36 124.8 2.6 1.9e-36 124.8 2.6 2.9 3 1 0 3 3 3 1 Multicopper oxidase Cu-oxidase_3 PF07732.15 ADV25598.1 - 6.1e-32 110.1 3.3 1.1e-28 99.7 2.6 3.1 3 0 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 ADV25598.1 - 2.3e-29 102.6 2.5 5.7e-28 98.0 0.2 3.1 3 0 0 3 3 3 1 Multicopper oxidase Phage_30_8 PF06019.11 ADV25598.1 - 1.3 9.0 7.3 8 6.4 0.1 3.8 3 2 1 4 4 4 0 Phage GP30.8 protein GST_N_3 PF13417.6 ADV25599.1 - 9.4e-19 67.6 0.1 2e-18 66.6 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 ADV25599.1 - 2.4e-16 59.8 0.0 4.3e-16 59.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 ADV25599.1 - 4.4e-08 33.4 0.1 7.5e-08 32.6 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 ADV25599.1 - 4.9e-07 29.7 0.1 8.8e-07 28.9 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ADV25599.1 - 0.00012 22.2 0.0 0.00022 21.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 ADV25599.1 - 0.0096 16.1 0.0 0.022 15.0 0.0 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 ADV25599.1 - 0.055 14.0 0.0 0.092 13.3 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Glutaredoxin PF00462.24 ADV25599.1 - 0.097 12.9 0.0 0.27 11.5 0.0 1.8 1 0 0 1 1 1 0 Glutaredoxin Exo_endo_phos PF03372.23 ADV25600.1 - 1.3e-19 70.6 0.0 3.9e-19 69.1 0.0 1.7 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family His_Phos_1 PF00300.22 ADV25601.1 - 1.1e-09 38.3 0.0 0.0011 18.7 0.0 2.2 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) TPT PF03151.16 ADV25602.1 - 1.7e-34 119.5 11.6 2.2e-34 119.1 11.6 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family UAA PF08449.11 ADV25602.1 - 6.6e-10 38.7 17.3 1.6e-09 37.4 17.3 1.6 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.20 ADV25602.1 - 3.4e-09 37.0 28.5 6.9e-05 23.0 12.1 2.2 2 0 0 2 2 2 2 EamA-like transporter family MIF4G PF02854.19 ADV25603.1 - 2.9e-22 79.4 0.1 6.5e-22 78.2 0.1 1.6 1 0 0 1 1 1 1 MIF4G domain MA3 PF02847.17 ADV25603.1 - 1.3e-15 57.4 0.0 3.6e-15 55.9 0.0 1.8 1 0 0 1 1 1 1 MA3 domain Transposase_28 PF04195.12 ADV25603.1 - 0.58 10.4 1.9 0.5 10.6 0.1 1.7 2 0 0 2 2 2 0 Putative gypsy type transposon ETC_C1_NDUFA5 PF04716.14 ADV25604.1 - 3.5e-26 90.8 0.1 5.5e-26 90.2 0.1 1.3 1 0 0 1 1 1 1 ETC complex I subunit conserved region Img2 PF05046.14 ADV25604.1 - 0.034 14.5 0.0 0.044 14.1 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial large subunit ribosomal protein (Img2) TPR_12 PF13424.6 ADV25604.1 - 0.051 13.9 0.1 0.1 12.9 0.1 1.5 1 1 0 1 1 1 0 Tetratricopeptide repeat zf-MIZ PF02891.20 ADV25605.1 - 2.8e-16 59.0 3.8 4.9e-16 58.2 3.8 1.4 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger PINIT PF14324.6 ADV25605.1 - 1.1e-11 45.3 0.0 2.1e-11 44.4 0.0 1.3 1 0 0 1 1 1 1 PINIT domain zf-Nse PF11789.8 ADV25605.1 - 2.6e-05 23.9 0.1 6.5e-05 22.7 0.1 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_2 PF13639.6 ADV25605.1 - 0.86 10.0 2.9 1.6 9.1 2.9 1.4 1 0 0 1 1 1 0 Ring finger domain Diphthamide_syn PF01866.17 ADV25606.1 - 1.2e-76 258.1 0.0 1.4e-76 257.8 0.0 1.1 1 0 0 1 1 1 1 Putative diphthamide synthesis protein ThiF PF00899.21 ADV25608.1 - 6.1e-17 61.8 0.0 9.3e-17 61.2 0.0 1.2 1 1 0 1 1 1 1 ThiF family Shikimate_DH PF01488.20 ADV25608.1 - 0.15 12.1 0.0 0.31 11.1 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Amidase PF01425.21 ADV25609.1 - 1e-96 324.7 0.0 1.2e-96 324.4 0.0 1.0 1 0 0 1 1 1 1 Amidase MciZ PF13072.6 ADV25609.1 - 0.13 12.1 0.2 0.3 10.9 0.2 1.5 1 0 0 1 1 1 0 Mother cell inhibitor of FtsZ GILT PF03227.16 ADV25610.1 - 5.2e-11 42.7 0.0 8.7e-11 42.0 0.0 1.4 1 0 0 1 1 1 1 Gamma interferon inducible lysosomal thiol reductase (GILT) Asp PF00026.23 ADV25611.1 - 1e-12 48.2 0.1 1.4e-12 47.7 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease DPBB_1 PF03330.18 ADV25612.1 - 9.5e-08 32.2 0.1 3.3e-07 30.5 0.1 2.0 1 1 0 1 1 1 1 Lytic transglycolase VWD PF00094.25 ADV25612.1 - 0.1 12.8 0.8 0.96 9.7 0.0 2.8 3 1 0 4 4 4 0 von Willebrand factor type D domain PAS_3 PF08447.12 ADV25614.1 - 6.3e-13 48.8 0.0 7.8e-10 38.9 0.0 2.2 2 0 0 2 2 2 2 PAS fold PAS PF00989.25 ADV25614.1 - 6.1e-07 29.4 0.0 1.4e-06 28.3 0.0 1.5 1 0 0 1 1 1 1 PAS fold PAS_11 PF14598.6 ADV25614.1 - 5.4e-06 26.5 0.0 2.8e-05 24.2 0.0 2.0 2 0 0 2 2 2 1 PAS domain PAS_9 PF13426.7 ADV25614.1 - 0.00013 22.1 0.0 0.0012 19.0 0.0 2.2 2 0 0 2 2 2 1 PAS domain PAS_4 PF08448.10 ADV25614.1 - 0.00077 19.7 0.0 0.0028 17.9 0.0 1.8 2 0 0 2 2 2 1 PAS fold PAS_2 PF08446.11 ADV25614.1 - 0.031 14.9 0.0 0.24 12.1 0.0 2.1 2 0 0 2 2 2 0 PAS fold PAS_8 PF13188.7 ADV25614.1 - 0.068 13.2 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 PAS domain NCBP3 PF10309.9 ADV25615.1 - 7.3e-09 35.3 0.0 1.2e-08 34.6 0.0 1.4 1 0 0 1 1 1 1 Nuclear cap-binding protein subunit 3 FoP_duplication PF13865.6 ADV25615.1 - 6.1 7.5 27.9 1.1 9.9 5.1 4.0 3 1 1 4 4 4 0 C-terminal duplication domain of Friend of PRMT1 AA_permease PF00324.21 ADV25617.1 - 2.5e-138 461.7 39.7 3.2e-138 461.3 39.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 ADV25617.1 - 1.3e-45 156.0 44.9 1.6e-45 155.7 44.9 1.1 1 0 0 1 1 1 1 Amino acid permease NCE101 PF11654.8 ADV25617.1 - 0.15 11.8 2.0 0.37 10.5 0.3 2.3 2 0 0 2 2 2 0 Non-classical export protein 1 HemY_N PF07219.13 ADV25617.1 - 0.64 10.2 2.8 8.9 6.6 0.0 3.0 2 1 0 2 2 2 0 HemY protein N-terminus Cupin_5 PF06172.11 ADV25618.1 - 1.1e-30 106.7 0.0 1.4e-30 106.3 0.0 1.1 1 0 0 1 1 1 1 Cupin superfamily (DUF985) CM_2 PF01817.21 ADV25619.1 - 0.025 14.9 0.3 0.15 12.5 0.2 2.1 2 1 0 2 2 2 0 Chorismate mutase type II zf-CHCC PF10276.9 ADV25620.1 - 1.1e-13 50.9 1.3 1.7e-13 50.3 1.3 1.3 1 0 0 1 1 1 1 Zinc-finger domain zf_C2H2_6 PF18450.1 ADV25620.1 - 0.15 11.8 0.0 0.3 10.8 0.0 1.5 1 0 0 1 1 1 0 Zinc Finger domain Acetyltransf_7 PF13508.7 ADV25622.1 - 0.012 16.1 0.0 0.021 15.2 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ADV25622.1 - 0.037 14.3 0.1 0.081 13.2 0.1 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family ACBP PF00887.19 ADV25623.1 - 2.8e-22 78.7 0.1 2.1e-21 75.9 0.0 2.0 1 1 1 2 2 2 1 Acyl CoA binding protein Enolase_C PF00113.22 ADV25625.1 - 7.2e-113 376.7 0.0 9.4e-113 376.3 0.0 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 ADV25625.1 - 1.1e-49 168.0 0.0 1.9e-49 167.2 0.0 1.4 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 ADV25625.1 - 7.8e-09 35.4 0.0 1.5e-08 34.5 0.0 1.3 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 ADV25625.1 - 0.0093 15.1 0.2 0.024 13.8 0.0 1.8 2 0 0 2 2 2 1 Methylaspartate ammonia-lyase C-terminus SRF-TF PF00319.18 ADV25626.1 - 1.6e-19 69.1 0.0 2.6e-19 68.4 0.0 1.3 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) NMT_C PF02799.15 ADV25627.1 - 7.7e-86 286.9 0.0 1.1e-85 286.5 0.0 1.2 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain NMT PF01233.19 ADV25627.1 - 7.3e-77 256.7 0.0 1.1e-76 256.1 0.0 1.3 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain Acetyltransf_1 PF00583.25 ADV25627.1 - 0.0045 17.2 0.1 0.037 14.3 0.0 2.4 2 1 1 3 3 3 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 ADV25627.1 - 0.027 14.6 0.1 0.081 13.0 0.0 1.8 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain YL1 PF05764.13 ADV25627.1 - 0.084 13.0 8.4 1.1 9.3 10.2 1.8 2 0 0 2 2 2 0 YL1 nuclear protein NTP_transf_9 PF04248.12 ADV25627.1 - 0.12 12.3 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF427) Cnd2 PF05786.14 ADV25627.1 - 6.7 5.2 10.1 12 4.4 10.1 1.3 1 0 0 1 1 1 0 Condensin complex subunit 2 Ten1 PF12658.7 ADV25628.1 - 0.091 12.7 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 Telomere capping, CST complex subunit NUC173 PF08161.12 ADV25629.1 - 4.8e-47 160.3 0.0 1.3e-45 155.6 0.0 3.2 3 0 0 3 3 3 1 NUC173 domain Dopey_N PF04118.14 ADV25629.1 - 0.054 12.6 0.7 0.11 11.5 0.0 1.8 2 0 0 2 2 2 0 Dopey, N-terminal DRIM PF07539.12 ADV25629.1 - 0.16 10.2 1.5 0.2 9.9 0.2 1.8 2 0 0 2 2 2 0 Down-regulated in metastasis DUF3385 PF11865.8 ADV25629.1 - 0.18 11.7 0.1 13 5.6 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3385) MMS19_C PF12460.8 ADV25629.1 - 0.59 9.2 10.5 0.27 10.3 0.4 3.3 2 0 0 2 2 2 0 RNAPII transcription regulator C-terminal HATPase_c PF02518.26 ADV25630.1 - 4e-17 62.7 1.3 1.4e-16 60.9 0.1 2.6 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ADV25630.1 - 3.7e-16 59.3 0.3 3e-12 46.7 0.2 2.6 2 0 0 2 2 2 2 Response regulator receiver domain HisKA PF00512.25 ADV25630.1 - 5.1e-06 26.4 0.3 1.6e-05 24.8 0.3 1.9 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain Xpo1 PF08389.12 ADV25631.1 - 9.7e-23 80.9 0.0 7.7e-22 78.0 0.0 2.4 2 0 0 2 2 2 1 Exportin 1-like protein IBN_N PF03810.19 ADV25631.1 - 5.5e-07 29.4 0.1 1.5e-06 28.0 0.1 1.8 1 0 0 1 1 1 1 Importin-beta N-terminal domain Importin_rep PF18773.1 ADV25631.1 - 0.13 12.0 0.0 0.22 11.2 0.0 1.4 1 0 0 1 1 1 0 Importin 13 repeat SAC3_GANP PF03399.16 ADV25632.1 - 9.9e-28 97.4 6.0 6.8e-26 91.3 6.0 2.1 1 1 0 1 1 1 1 SAC3/GANP family CSN8_PSD8_EIF3K PF10075.9 ADV25632.1 - 4.2e-10 39.8 1.6 5.2e-10 39.5 0.5 1.7 2 0 0 2 2 2 1 CSN8/PSMD8/EIF3K family COX5A PF02284.16 ADV25632.1 - 0.086 12.9 0.0 0.21 11.6 0.0 1.6 1 0 0 1 1 1 0 Cytochrome c oxidase subunit Va DUF3323 PF11796.8 ADV25632.1 - 2.2 8.1 4.8 18 5.1 0.2 3.2 3 1 0 3 3 3 0 Protein of unknown function N-terminus (DUF3323) RRM_1 PF00076.22 ADV25634.1 - 3e-21 75.0 0.0 3.5e-13 49.2 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ADV25634.1 - 3.7e-09 36.2 0.0 0.00078 19.0 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ADV25634.1 - 0.024 14.5 0.0 0.058 13.3 0.0 1.6 1 0 0 1 1 1 0 Occluded RNA-recognition motif Limkain-b1 PF11608.8 ADV25634.1 - 0.087 12.9 0.2 5.2 7.2 0.0 2.7 2 1 0 2 2 2 0 Limkain b1 DUF3306 PF11748.8 ADV25634.1 - 4.8 8.1 10.2 4.5 8.2 3.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3306) Sugar_tr PF00083.24 ADV25635.1 - 5.3e-122 407.9 13.2 6.1e-122 407.7 13.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ADV25635.1 - 9.8e-22 77.3 29.5 9.4e-19 67.5 20.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily D123 PF07065.14 ADV25637.1 - 3e-84 282.8 0.0 3.8e-84 282.4 0.0 1.1 1 0 0 1 1 1 1 D123 CUE PF02845.16 ADV25637.1 - 0.052 13.3 0.1 0.27 11.0 0.0 2.3 2 0 0 2 2 2 0 CUE domain WD40 PF00400.32 ADV25638.1 - 1.5e-07 32.0 13.8 0.44 11.5 0.4 6.1 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV25638.1 - 2.1e-06 27.9 0.2 0.0052 17.1 0.0 4.7 5 1 1 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 ADV25638.1 - 0.0014 19.1 0.0 2.9 8.5 0.0 3.0 2 0 0 2 2 2 2 PQQ-like domain RAB3GAP2_N PF14655.6 ADV25638.1 - 0.016 14.5 0.0 2.3 7.4 0.0 2.2 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Pkinase PF00069.25 ADV25640.1 - 3.4e-40 138.1 0.0 3.3e-39 134.9 0.0 2.6 4 0 0 4 4 4 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV25640.1 - 2e-21 76.4 0.0 8.1e-21 74.5 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ADV25640.1 - 0.0011 18.3 0.0 0.0021 17.4 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 ADV25640.1 - 0.0014 18.6 0.0 0.003 17.5 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF3947 PF13135.6 ADV25640.1 - 0.25 11.6 15.4 4 7.7 14.7 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3947) Spt20 PF12090.8 ADV25640.1 - 1.4 8.5 21.1 0.38 10.3 14.9 2.7 2 0 0 2 2 2 0 Spt20 family GARS_A PF01071.19 ADV25641.1 - 2.8e-78 262.2 0.0 4.5e-78 261.5 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain AIRS_C PF02769.22 ADV25641.1 - 2e-34 119.0 0.0 5e-34 117.7 0.0 1.7 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain GARS_N PF02844.15 ADV25641.1 - 4.2e-32 110.8 0.0 1.2e-31 109.3 0.0 1.9 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, N domain GARS_C PF02843.16 ADV25641.1 - 1.9e-26 92.1 0.0 5.4e-26 90.7 0.0 1.9 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, C domain AIRS PF00586.24 ADV25641.1 - 2.7e-15 56.8 2.6 3.2e-14 53.3 1.1 2.6 2 0 0 2 2 2 1 AIR synthase related protein, N-terminal domain ATP-grasp_3 PF02655.14 ADV25641.1 - 0.0033 17.5 0.0 0.0066 16.5 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain CPSase_L_D2 PF02786.17 ADV25641.1 - 0.074 12.5 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 Carbamoyl-phosphate synthase L chain, ATP binding domain Cwf_Cwc_15 PF04889.12 ADV25642.1 - 1.4e-84 283.7 20.9 1.6e-84 283.5 20.9 1.0 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein TFIIF_alpha PF05793.12 ADV25642.1 - 0.00011 21.0 18.5 0.00014 20.6 18.5 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Nop14 PF04147.12 ADV25642.1 - 0.0086 14.4 20.4 0.0095 14.2 20.4 1.1 1 0 0 1 1 1 1 Nop14-like family SDA1 PF05285.12 ADV25642.1 - 0.012 15.1 21.5 0.013 14.9 21.5 1.1 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 ADV25642.1 - 0.056 11.7 14.9 0.057 11.7 14.9 1.1 1 0 0 1 1 1 0 CDC45-like protein BUD22 PF09073.10 ADV25642.1 - 0.2 10.9 21.2 0.23 10.7 21.2 1.2 1 0 0 1 1 1 0 BUD22 PPP4R2 PF09184.11 ADV25642.1 - 0.41 10.2 13.7 0.6 9.7 13.7 1.4 1 0 0 1 1 1 0 PPP4R2 SAPS PF04499.15 ADV25642.1 - 1.9 7.2 9.8 2 7.1 9.8 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein PDDEXK_6 PF04720.12 ADV25642.1 - 2.7 7.9 8.0 5.2 6.9 8.0 1.5 1 0 0 1 1 1 0 PDDEXK-like family of unknown function Vfa1 PF08432.10 ADV25642.1 - 2.8 8.3 16.2 5.4 7.3 16.2 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Nop53 PF07767.11 ADV25642.1 - 3.2 7.1 25.1 0.043 13.2 18.0 1.4 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) Hid1 PF12722.7 ADV25642.1 - 3.6 5.6 5.1 4 5.4 5.1 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein TFIIA PF03153.13 ADV25642.1 - 5 7.0 26.2 4.4 7.2 25.4 1.3 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Paf1 PF03985.13 ADV25642.1 - 5 6.0 18.4 7.3 5.5 18.4 1.3 1 0 0 1 1 1 0 Paf1 DNA_pol_phi PF04931.13 ADV25642.1 - 5.1 5.1 35.9 7 4.6 35.9 1.1 1 0 0 1 1 1 0 DNA polymerase phi DUF4746 PF15928.5 ADV25642.1 - 6.2 6.1 10.9 8.9 5.6 10.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) GCV_H PF01597.19 ADV25643.1 - 3.4e-42 143.2 0.0 3.9e-42 143.0 0.0 1.0 1 0 0 1 1 1 1 Glycine cleavage H-protein Biotin_lipoyl PF00364.22 ADV25643.1 - 3.8e-05 23.4 0.2 6.5e-05 22.7 0.2 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme RnfC_N PF13375.6 ADV25643.1 - 0.00043 20.2 0.1 0.00069 19.5 0.1 1.3 1 0 0 1 1 1 1 RnfC Barrel sandwich hybrid domain NLE PF08154.12 ADV25644.1 - 1.7e-16 60.5 0.0 2.8e-16 59.8 0.0 1.4 1 0 0 1 1 1 1 NLE (NUC135) domain WD40 PF00400.32 ADV25644.1 - 6.2e-12 45.8 16.0 0.0011 19.7 0.1 6.3 6 0 0 6 6 6 5 WD domain, G-beta repeat Opy2 PF09463.10 ADV25645.1 - 4.1e-07 30.2 22.7 6.3e-07 29.6 22.7 1.3 1 0 0 1 1 1 1 Opy2 protein Seadorna_VP6 PF07407.11 ADV25645.1 - 0.16 10.9 0.0 0.23 10.3 0.0 1.1 1 0 0 1 1 1 0 Seadornavirus VP6 protein MOZ_SAS PF01853.18 ADV25646.1 - 4.9e-54 182.7 0.0 6.7e-53 179.0 0.0 2.3 1 1 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 ADV25646.1 - 3e-18 65.2 2.4 1.3e-08 34.3 0.2 2.7 2 0 0 2 2 2 2 MYST family zinc finger domain Tudor-knot PF11717.8 ADV25646.1 - 4.8e-08 32.8 0.0 9.9e-08 31.8 0.0 1.6 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain SPX PF03105.19 ADV25646.1 - 0.0097 15.9 0.8 0.014 15.4 0.4 1.4 2 0 0 2 2 2 1 SPX domain Acetyltransf_7 PF13508.7 ADV25646.1 - 0.13 12.7 0.0 0.27 11.7 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain MFS_1 PF07690.16 ADV25647.1 - 8.5e-10 38.1 30.3 8.5e-10 38.1 30.3 2.7 2 1 0 2 2 2 1 Major Facilitator Superfamily zf-CHY PF05495.12 ADV25648.1 - 2.6e-14 53.5 15.8 5e-14 52.6 15.8 1.5 1 0 0 1 1 1 1 CHY zinc finger Cys_rich_KTR PF14205.6 ADV25648.1 - 0.0061 16.3 8.4 0.14 12.0 0.1 2.6 1 1 1 2 2 2 2 Cysteine-rich KTR SF3A2 PF16835.5 ADV25648.1 - 0.018 15.4 0.1 0.027 14.8 0.1 1.4 1 1 0 1 1 1 0 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) Zn_Tnp_IS1595 PF12760.7 ADV25648.1 - 0.025 14.5 10.1 1.6 8.8 6.4 2.4 2 0 0 2 2 2 0 Transposase zinc-ribbon domain DUF3797 PF12677.7 ADV25648.1 - 0.038 13.9 3.5 0.44 10.5 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3797) zinc_ribbon_4 PF13717.6 ADV25648.1 - 0.048 13.6 13.5 1.5 8.8 0.2 4.1 4 0 0 4 4 4 0 zinc-ribbon domain Zn-ribbon_8 PF09723.10 ADV25648.1 - 0.065 13.4 3.4 0.065 13.4 3.4 2.7 2 1 0 2 2 2 0 Zinc ribbon domain Elf1 PF05129.13 ADV25648.1 - 0.15 12.1 10.7 1.1 9.3 10.7 2.1 1 1 0 1 1 1 0 Transcription elongation factor Elf1 like DpnI PF06044.12 ADV25648.1 - 0.23 11.1 5.4 0.14 11.7 1.9 1.9 1 1 1 2 2 2 0 Dam-replacing family zinc_ribbon_9 PF14369.6 ADV25648.1 - 0.57 10.5 10.0 0.16 12.3 2.0 2.9 2 1 1 3 3 3 0 zinc-ribbon zf-UDP PF14569.6 ADV25648.1 - 0.81 9.8 10.1 2.3 8.4 7.8 2.4 1 1 1 2 2 2 0 Zinc-binding RING-finger Zn_ribbon_SprT PF17283.2 ADV25648.1 - 0.82 9.6 10.8 0.32 10.9 0.6 2.8 2 1 1 3 3 3 0 SprT-like zinc ribbon domain zinc_ribbon_10 PF10058.9 ADV25648.1 - 1.1 9.0 6.5 0.6 9.9 1.0 2.3 1 1 1 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein HypA PF01155.19 ADV25648.1 - 2.2 8.3 12.0 0.065 13.3 2.3 2.2 1 1 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF4379 PF14311.6 ADV25648.1 - 2.7 8.4 8.3 1.5 9.3 0.6 2.4 2 0 0 2 2 2 0 Probable Zinc-ribbon domain zf-H2C2_2 PF13465.6 ADV25648.1 - 6.3 7.4 13.4 2 9.0 0.3 3.3 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2H2 PF00096.26 ADV25649.1 - 2.9e-08 33.7 21.6 0.00019 21.7 2.9 3.9 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ADV25649.1 - 7e-05 23.1 4.4 7e-05 23.1 4.4 4.6 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 ADV25649.1 - 0.012 16.4 17.7 0.15 13.0 1.3 4.0 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 ADV25649.1 - 0.038 14.3 0.8 1.1 9.6 0.1 3.0 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding 2OG-FeII_Oxy PF03171.20 ADV25650.1 - 1.1e-10 41.8 0.0 1.9e-10 41.1 0.0 1.5 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 ADV25650.1 - 6.9e-07 30.0 0.0 1.8e-06 28.7 0.0 1.7 2 0 0 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal Rep_fac_C PF08542.11 ADV25651.1 - 4.3e-20 71.9 0.0 1.1e-19 70.6 0.0 1.7 1 0 0 1 1 1 1 Replication factor C C-terminal domain AAA PF00004.29 ADV25651.1 - 5.5e-17 62.4 0.0 9e-17 61.7 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 ADV25651.1 - 6.1e-14 52.1 0.0 2.5e-10 40.3 0.1 2.4 1 1 1 2 2 2 2 DNA polymerase III, delta subunit Rad17 PF03215.15 ADV25651.1 - 5.1e-08 33.0 0.0 1.1e-07 31.9 0.0 1.5 1 1 0 1 1 1 1 Rad17 P-loop domain DNA_pol3_delta PF06144.13 ADV25651.1 - 2.2e-07 30.8 0.1 4e-07 30.0 0.1 1.3 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_14 PF13173.6 ADV25651.1 - 5.3e-07 29.7 0.0 1.1e-06 28.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 ADV25651.1 - 1.9e-06 27.7 0.0 1.8e-05 24.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.13 ADV25651.1 - 5.7e-06 25.7 0.0 8.4e-06 25.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_assoc_2 PF16193.5 ADV25651.1 - 6.9e-06 26.3 0.0 2.2e-05 24.7 0.0 1.9 1 0 0 1 1 1 1 AAA C-terminal domain AAA_11 PF13086.6 ADV25651.1 - 8.6e-06 25.7 0.0 2.6e-05 24.1 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ADV25651.1 - 2.1e-05 25.0 0.1 9.7e-05 22.8 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.12 ADV25651.1 - 0.00012 21.8 0.0 0.00022 21.0 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 ADV25651.1 - 0.0002 21.6 0.3 0.095 13.0 0.0 2.6 2 1 1 3 3 2 1 AAA domain AAA_5 PF07728.14 ADV25651.1 - 0.00023 21.2 0.1 0.0014 18.6 0.1 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 ADV25651.1 - 0.00046 20.0 0.0 0.00082 19.2 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ResIII PF04851.15 ADV25651.1 - 0.00049 20.2 0.0 0.015 15.3 0.0 2.1 1 1 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 ADV25651.1 - 0.00089 19.6 0.4 0.34 11.2 0.1 2.6 1 1 1 2 2 2 1 AAA domain AAA_18 PF13238.6 ADV25651.1 - 0.0017 18.9 0.0 0.01 16.4 0.0 2.0 1 1 1 2 2 2 1 AAA domain AAA_24 PF13479.6 ADV25651.1 - 0.0021 17.8 0.0 0.0043 16.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 ADV25651.1 - 0.0051 16.4 0.0 0.011 15.2 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region DEAD PF00270.29 ADV25651.1 - 0.011 15.6 0.5 0.044 13.5 0.4 2.0 1 1 1 2 2 2 0 DEAD/DEAH box helicase Viral_helicase1 PF01443.18 ADV25651.1 - 0.016 15.0 0.0 0.022 14.5 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_28 PF13521.6 ADV25651.1 - 0.02 15.2 0.0 0.043 14.1 0.0 1.7 1 1 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 ADV25651.1 - 0.024 14.3 0.0 0.064 13.0 0.0 1.6 1 1 0 1 1 1 0 IstB-like ATP binding protein Mg_chelatase PF01078.21 ADV25651.1 - 0.029 13.8 0.0 0.16 11.3 0.0 2.0 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI ATPase_2 PF01637.18 ADV25651.1 - 0.036 14.0 0.0 0.058 13.3 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 ADV25651.1 - 0.049 14.0 0.0 0.12 12.8 0.0 1.7 1 0 0 1 1 1 0 RNA helicase TniB PF05621.11 ADV25651.1 - 0.05 13.0 0.1 1.5 8.2 0.0 2.2 1 1 1 2 2 2 0 Bacterial TniB protein MCM PF00493.23 ADV25651.1 - 0.055 12.6 0.0 0.092 11.8 0.0 1.3 1 0 0 1 1 1 0 MCM P-loop domain TIP49 PF06068.13 ADV25651.1 - 0.063 12.5 0.0 0.13 11.5 0.0 1.5 1 1 0 1 1 1 0 TIP49 P-loop domain AAA_25 PF13481.6 ADV25651.1 - 0.11 12.1 0.1 0.35 10.4 0.1 2.1 1 1 0 1 1 1 0 AAA domain SNF2_N PF00176.23 ADV25651.1 - 0.11 11.2 0.2 0.29 9.8 0.1 1.6 1 1 1 2 2 2 0 SNF2 family N-terminal domain GREB1 PF15782.5 ADV25652.1 - 5.4 4.0 11.4 8.1 3.4 11.4 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer HPP PF04982.13 ADV25653.1 - 2.7e-19 69.5 1.6 4.9e-19 68.7 1.6 1.4 1 0 0 1 1 1 1 HPP family F-box PF00646.33 ADV25654.1 - 6.2e-06 25.9 0.7 0.00038 20.3 0.2 2.7 3 0 0 3 3 3 1 F-box domain F-box-like PF12937.7 ADV25654.1 - 0.0012 18.6 0.3 0.0044 16.9 0.3 2.0 1 0 0 1 1 1 1 F-box-like YCII PF03795.14 ADV25655.1 - 5.5e-06 26.7 0.0 7.6e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 YCII-related domain Cation_efflux PF01545.21 ADV25657.1 - 3.9e-25 88.7 4.9 5e-25 88.4 4.9 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 ADV25657.1 - 1.8e-05 24.8 0.2 3.5e-05 23.9 0.2 1.4 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter Toxin_trans PF07952.12 ADV25657.1 - 0.14 11.3 0.1 0.22 10.6 0.1 1.2 1 0 0 1 1 1 0 Clostridium neurotoxin, Translocation domain PGM_PMM_I PF02878.16 ADV25658.1 - 3.4e-37 127.2 0.2 5.1e-37 126.7 0.2 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 ADV25658.1 - 6.6e-27 94.0 0.0 1.2e-26 93.1 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 ADV25658.1 - 8.2e-13 48.9 0.0 1.8e-12 47.8 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 ADV25658.1 - 5.8e-08 32.8 0.0 1.4e-07 31.6 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain SNARE_assoc PF09335.11 ADV25659.1 - 1.1e-18 67.8 8.3 1.1e-18 67.8 8.3 2.4 3 0 0 3 3 3 1 SNARE associated Golgi protein Yip1 PF04893.17 ADV25659.1 - 3.2 7.4 22.5 3.3 7.4 11.3 3.0 2 2 0 2 2 2 0 Yip1 domain PAM2 PF07145.15 ADV25660.1 - 0.0086 15.7 0.1 0.022 14.4 0.1 1.7 1 0 0 1 1 1 1 Ataxin-2 C-terminal region Lipocalin_9 PF17186.4 ADV25660.1 - 0.16 12.2 1.6 0.39 11.0 1.0 2.0 2 1 0 2 2 2 0 Lipocalin-like domain Apelin PF15360.6 ADV25660.1 - 0.88 10.2 2.7 24 5.6 0.0 2.6 2 0 0 2 2 2 0 APJ endogenous ligand Pkinase PF00069.25 ADV25661.1 - 6.6e-64 215.8 0.0 8.3e-64 215.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV25661.1 - 8.8e-30 103.8 0.0 1.2e-29 103.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 ADV25661.1 - 2.5e-18 66.5 0.0 9.7e-18 64.6 0.0 2.1 1 0 0 1 1 1 1 Protein kinase C terminal domain C2 PF00168.30 ADV25661.1 - 2.1e-10 40.8 0.0 7.6e-06 26.2 0.0 2.4 2 0 0 2 2 2 2 C2 domain Kinase-like PF14531.6 ADV25661.1 - 1.3e-07 31.3 0.0 1.1e-06 28.3 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 ADV25661.1 - 0.00011 21.3 0.0 0.0002 20.5 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain FTA2 PF13095.6 ADV25661.1 - 0.0028 17.3 0.1 0.38 10.3 0.1 2.3 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 ADV25661.1 - 0.042 13.2 0.0 0.068 12.5 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ADV25661.1 - 0.053 13.4 0.0 0.099 12.6 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family NOA36 PF06524.12 ADV25661.1 - 0.61 9.3 10.7 6.5 6.0 12.8 1.5 2 0 0 2 2 2 0 NOA36 protein GCS PF03074.16 ADV25662.1 - 5.4e-171 568.9 0.0 7.5e-171 568.4 0.0 1.2 1 0 0 1 1 1 1 Glutamate-cysteine ligase DUF1338 PF07063.13 ADV25663.1 - 2.7e-111 371.8 0.0 3.4e-111 371.6 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1338) Polysacc_deac_1 PF01522.21 ADV25664.1 - 4.9e-28 97.5 0.0 6.8e-28 97.0 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.15 ADV25664.1 - 0.032 13.4 0.0 0.039 13.2 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 57 VWA PF00092.28 ADV25666.1 - 1.8e-09 38.1 0.0 2.6e-09 37.6 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 ADV25666.1 - 1.1e-08 35.7 0.0 2e-08 34.8 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain Med25_VWA PF11265.8 ADV25666.1 - 0.00012 22.0 0.0 0.00018 21.4 0.0 1.2 1 0 0 1 1 1 1 Mediator complex subunit 25 von Willebrand factor type A Integrin_beta PF00362.18 ADV25666.1 - 0.0099 15.6 0.0 0.082 12.6 0.0 2.0 2 0 0 2 2 2 1 Integrin beta chain VWA domain EF-1_beta_acid PF10587.9 ADV25666.1 - 5.2 7.6 8.3 16 6.1 8.3 1.9 1 0 0 1 1 1 0 Eukaryotic elongation factor 1 beta central acidic region GSHPx PF00255.19 ADV25667.1 - 1.4e-40 137.2 0.1 1.7e-40 137.0 0.1 1.1 1 0 0 1 1 1 1 Glutathione peroxidase Redoxin PF08534.10 ADV25667.1 - 0.0067 16.2 0.0 0.014 15.1 0.0 1.6 1 1 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 ADV25667.1 - 0.007 16.3 0.0 0.0097 15.8 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Myb_DNA-binding PF00249.31 ADV25669.1 - 5.5e-24 84.1 13.0 3.6e-12 46.3 0.2 4.6 4 2 0 4 4 4 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ADV25669.1 - 7e-16 58.2 5.6 2.8e-12 46.7 0.6 3.9 3 1 1 4 4 4 2 Myb-like DNA-binding domain Rz1 PF06085.11 ADV25669.1 - 1.7 8.4 5.7 4 7.3 5.7 1.5 1 0 0 1 1 1 0 Lipoprotein Rz1 precursor GREB1 PF15782.5 ADV25669.1 - 8.2 3.4 12.9 11 2.9 12.9 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF3337 PF11816.8 ADV25670.1 - 2.8e-32 112.0 0.0 4.4e-32 111.3 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3337) WD40 PF00400.32 ADV25670.1 - 5.5e-19 68.2 13.5 1.3e-05 25.8 0.0 8.0 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ADV25670.1 - 4e-06 27.0 0.1 0.0096 16.2 0.0 3.4 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ADV25670.1 - 0.059 12.0 0.1 18 3.8 0.0 3.0 3 0 0 3 3 3 0 Nucleoporin Nup120/160 Fungal_trans PF04082.18 ADV25671.1 - 2.3e-10 40.0 0.2 4.2e-10 39.1 0.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ADV25671.1 - 1.2e-05 25.3 13.1 2.2e-05 24.5 13.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AT_hook PF02178.19 ADV25671.1 - 0.3 11.1 6.8 1.4 9.1 6.8 2.2 1 0 0 1 1 1 0 AT hook motif TALPID3 PF15324.6 ADV25672.1 - 0.0078 14.0 1.7 0.0081 13.9 1.7 1.0 1 0 0 1 1 1 1 Hedgehog signalling target RRS1 PF04939.12 ADV25673.1 - 1.5e-51 174.5 3.1 1.5e-51 174.5 3.1 1.5 2 0 0 2 2 2 1 Ribosome biogenesis regulatory protein (RRS1) NAD_binding_11 PF14833.6 ADV25674.1 - 5.2e-23 81.6 0.0 6.1e-23 81.4 0.0 1.1 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase DUF3450 PF11932.8 ADV25676.1 - 4.7e-05 22.8 9.6 4.7e-05 22.8 9.6 11.6 4 3 7 12 12 12 5 Protein of unknown function (DUF3450) TolA_bind_tri PF16331.5 ADV25676.1 - 0.00019 21.4 1.3 0.00019 21.4 1.3 13.9 9 4 5 14 14 14 4 TolA binding protein trimerisation PI3K_P85_iSH2 PF16454.5 ADV25676.1 - 0.0022 17.6 3.5 0.0022 17.6 3.5 10.4 5 3 6 11 11 11 4 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Cep57_CLD_2 PF14197.6 ADV25676.1 - 0.0055 16.8 2.9 0.0055 16.8 2.9 14.8 8 5 5 14 14 14 2 Centrosome localisation domain of PPC89 Surfac_D-trimer PF09006.11 ADV25676.1 - 0.58 10.1 14.6 0.51 10.3 0.7 5.7 6 0 0 6 6 6 0 Lung surfactant protein D coiled-coil trimerisation GRDP-like PF07173.12 ADV25678.1 - 9.5e-11 42.5 0.0 3e-07 31.2 0.0 2.6 2 0 0 2 2 2 2 Glycine-rich domain-containing protein-like zf-DNA_Pol PF08996.10 ADV25678.1 - 0.015 15.0 0.2 0.028 14.2 0.2 1.3 1 0 0 1 1 1 0 DNA Polymerase alpha zinc finger Amidohydro_1 PF01979.20 ADV25679.1 - 6.8e-32 111.1 1.2 8.9e-32 110.7 1.2 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 ADV25679.1 - 2.2e-07 30.7 0.2 9e-07 28.7 0.2 1.9 1 1 0 1 1 1 1 Amidohydrolase family MFS_1 PF07690.16 ADV25680.1 - 1.4e-19 70.2 26.6 3.3e-19 69.0 26.6 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily PDCD2_C PF04194.13 ADV25681.1 - 4.1e-30 105.1 0.3 3.8e-29 102.0 0.0 2.6 2 2 1 3 3 3 1 Programmed cell death protein 2, C-terminal putative domain ThiF PF00899.21 ADV25682.1 - 1.3e-21 77.1 0.0 2e-21 76.5 0.0 1.3 1 0 0 1 1 1 1 ThiF family T2SSG PF08334.11 ADV25682.1 - 0.069 13.2 0.2 0.85 9.7 0.0 2.4 3 0 0 3 3 3 0 Type II secretion system (T2SS), protein G CX9C PF16860.5 ADV25683.1 - 3.5e-16 58.9 7.4 1.3e-10 41.1 0.9 2.2 2 0 0 2 2 2 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, UCR_hinge PF02320.16 ADV25683.1 - 2e-05 24.7 6.3 0.0072 16.5 1.0 2.1 1 1 1 2 2 2 2 Ubiquinol-cytochrome C reductase hinge protein Cmc1 PF08583.10 ADV25683.1 - 7.5e-05 22.7 8.6 0.0066 16.4 0.7 3.1 2 1 0 2 2 2 2 Cytochrome c oxidase biogenesis protein Cmc1 like CHCH PF06747.13 ADV25683.1 - 0.00018 21.5 7.7 0.063 13.4 0.9 3.0 2 1 0 3 3 3 2 CHCH domain UPF0203 PF05254.12 ADV25683.1 - 0.004 17.4 9.3 0.45 10.8 0.5 3.1 1 1 2 3 3 3 2 Uncharacterised protein family (UPF0203) Pet191_N PF10203.9 ADV25683.1 - 0.0089 16.3 7.2 0.074 13.4 2.3 2.5 1 1 1 2 2 2 1 Cytochrome c oxidase assembly protein PET191 COX17 PF05051.13 ADV25683.1 - 0.014 15.7 6.9 0.25 11.7 0.9 2.9 2 1 1 3 3 3 0 Cytochrome C oxidase copper chaperone (COX17) GCK PF07802.11 ADV25683.1 - 0.028 14.8 1.0 0.028 14.8 1.0 2.3 1 1 2 3 3 3 0 GCK domain ABC2_membrane PF01061.24 ADV25684.1 - 1.6e-48 164.9 57.5 9.5e-36 123.2 16.0 3.2 4 0 0 4 4 4 2 ABC-2 type transporter ABC_tran PF00005.27 ADV25684.1 - 3.7e-37 127.9 0.0 8.4e-19 68.4 0.0 2.8 3 0 0 3 3 2 2 ABC transporter PDR_CDR PF06422.12 ADV25684.1 - 1.3e-24 85.8 12.9 2.8e-22 78.4 0.2 3.5 3 0 0 3 3 2 2 CDR ABC transporter AAA_16 PF13191.6 ADV25684.1 - 2.9e-07 31.0 0.0 0.0031 17.9 0.1 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA_21 PF13304.6 ADV25684.1 - 3e-07 30.5 0.0 0.034 14.0 0.0 3.2 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ADV25684.1 - 1.1e-05 25.1 3.1 0.0086 15.8 1.1 3.0 3 0 0 3 3 3 2 P-loop containing region of AAA domain AAA_25 PF13481.6 ADV25684.1 - 1.8e-05 24.4 1.0 0.002 17.7 0.2 2.7 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 ADV25684.1 - 9.4e-05 22.4 0.1 0.006 16.5 0.1 2.6 2 0 0 2 2 2 1 RsgA GTPase ABC_trans_N PF14510.6 ADV25684.1 - 0.00099 19.7 0.9 0.0026 18.3 0.0 2.1 2 0 0 2 2 2 1 ABC-transporter N-terminal AAA_22 PF13401.6 ADV25684.1 - 0.0012 19.1 0.0 0.43 10.8 0.1 2.8 3 0 0 3 3 2 1 AAA domain AAA_30 PF13604.6 ADV25684.1 - 0.0029 17.3 0.1 2.6 7.7 0.1 2.5 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 ADV25684.1 - 0.0035 17.4 0.1 2.7 8.1 0.0 3.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_23 PF13476.6 ADV25684.1 - 0.0052 17.3 1.9 0.049 14.1 0.0 2.8 3 0 0 3 3 3 1 AAA domain AAA_33 PF13671.6 ADV25684.1 - 0.013 15.7 0.1 9 6.5 0.2 3.2 3 0 0 3 3 3 0 AAA domain Ploopntkinase3 PF18751.1 ADV25684.1 - 0.032 14.2 0.0 0.46 10.4 0.0 2.4 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 NACHT PF05729.12 ADV25684.1 - 0.034 14.1 0.8 0.65 9.9 0.3 2.4 2 0 0 2 2 2 0 NACHT domain AAA_18 PF13238.6 ADV25684.1 - 0.039 14.5 0.0 19 5.8 0.0 3.5 3 0 0 3 3 3 0 AAA domain Zeta_toxin PF06414.12 ADV25684.1 - 0.073 12.3 0.3 6.5 6.0 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin AAA_28 PF13521.6 ADV25684.1 - 0.09 13.0 0.6 6.5 7.0 1.3 2.7 3 0 0 3 3 2 0 AAA domain cobW PF02492.19 ADV25684.1 - 0.42 10.2 1.0 2.5 7.7 0.9 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Sec61_beta PF03911.16 ADV25686.1 - 2.2e-15 56.4 1.0 2.8e-15 56.0 1.0 1.2 1 0 0 1 1 1 1 Sec61beta family PseudoU_synth_1 PF01416.20 ADV25687.1 - 2.6e-12 47.1 0.0 1.9e-08 34.7 0.0 2.7 2 0 0 2 2 2 2 tRNA pseudouridine synthase ThiF PF00899.21 ADV25688.1 - 1e-37 129.9 0.0 1.5e-37 129.3 0.0 1.2 1 0 0 1 1 1 1 ThiF family Sacchrp_dh_NADP PF03435.18 ADV25688.1 - 4.5e-05 23.7 0.2 0.00067 19.9 0.2 2.3 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_7 PF13241.6 ADV25688.1 - 0.00024 21.5 0.0 0.00063 20.1 0.0 1.6 1 0 0 1 1 1 1 Putative NAD(P)-binding DAO PF01266.24 ADV25688.1 - 0.037 13.6 0.6 0.037 13.6 0.6 1.7 2 0 0 2 2 2 0 FAD dependent oxidoreductase UDPG_MGDP_dh_N PF03721.14 ADV25688.1 - 0.041 13.4 0.1 0.074 12.6 0.1 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ApbA PF02558.16 ADV25688.1 - 0.058 13.0 0.0 0.13 11.9 0.0 1.6 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA C1_1 PF00130.22 ADV25689.1 - 2.7e-07 30.4 14.1 3e-05 23.8 2.9 2.4 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) UNC-79 PF14776.6 ADV25689.1 - 0.1 11.3 0.0 0.17 10.6 0.0 1.2 1 0 0 1 1 1 0 Cation-channel complex subunit UNC-79 PHD PF00628.29 ADV25689.1 - 0.11 12.4 13.7 0.055 13.4 2.9 2.6 2 0 0 2 2 2 0 PHD-finger C1_2 PF03107.16 ADV25689.1 - 0.12 12.7 14.7 0.19 12.1 3.5 2.5 2 0 0 2 2 2 0 C1 domain zf-HC5HC2H_2 PF13832.6 ADV25689.1 - 0.57 10.4 7.5 0.61 10.3 0.6 2.4 2 0 0 2 2 2 0 PHD-zinc-finger like domain zf-RING-like PF08746.11 ADV25689.1 - 1.8 8.9 17.6 1.8 8.9 6.0 2.7 2 0 0 2 2 2 0 RING-like domain FdhE PF04216.12 ADV25689.1 - 3 7.7 4.6 1.2 8.9 1.0 2.0 2 0 0 2 2 2 0 Protein involved in formate dehydrogenase formation zf-HC5HC2H PF13771.6 ADV25689.1 - 3.8 7.8 9.4 0.86 9.9 1.0 2.4 2 0 0 2 2 2 0 PHD-like zinc-binding domain Fcf2 PF08698.11 ADV25690.1 - 8.8e-20 70.9 1.7 8.8e-20 70.9 0.1 1.9 2 0 0 2 2 2 1 Fcf2 pre-rRNA processing Macoilin PF09726.9 ADV25690.1 - 7.7 4.9 15.1 9.8 4.6 15.1 1.2 1 0 0 1 1 1 0 Macoilin family EPL1 PF10513.9 ADV25691.1 - 2.3e-24 86.5 7.7 1.2e-22 81.0 0.0 3.4 3 0 0 3 3 3 1 Enhancer of polycomb-like DER1 PF04511.15 ADV25692.1 - 2.5e-50 171.1 6.9 2.8e-50 170.9 6.9 1.0 1 0 0 1 1 1 1 Der1-like family DUF2070 PF09843.9 ADV25692.1 - 0.0065 14.8 9.7 0.0079 14.5 9.7 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2070) DUF3488 PF11992.8 ADV25692.1 - 0.22 10.4 13.5 0.27 10.1 13.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3488) Pex2_Pex12 PF04757.14 ADV25692.1 - 0.54 9.8 7.2 1.6 8.3 6.9 1.8 1 1 1 2 2 2 0 Pex2 / Pex12 amino terminal region Sas10 PF09368.10 ADV25693.1 - 6.7e-25 87.4 8.6 6.7e-25 87.4 8.6 4.6 5 0 0 5 5 5 2 Sas10 C-terminal domain Sas10_Utp3 PF04000.15 ADV25693.1 - 0.011 16.3 2.1 0.04 14.5 0.0 2.9 2 0 0 2 2 2 0 Sas10/Utp3/C1D family PPTA PF01239.22 ADV25694.1 - 1.6e-47 157.9 11.4 1.8e-10 40.2 0.0 5.5 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat CortBP2 PF09727.9 ADV25694.1 - 0.037 13.9 0.5 0.93 9.4 0.1 2.6 3 0 0 3 3 3 0 Cortactin-binding protein-2 NdhL PF10716.9 ADV25694.1 - 0.091 12.7 0.1 0.18 11.8 0.1 1.4 1 0 0 1 1 1 0 NADH dehydrogenase transmembrane subunit Aminotran_4 PF01063.19 ADV25695.1 - 4.2e-29 102.0 0.0 6.8e-29 101.3 0.0 1.3 1 1 0 1 1 1 1 Amino-transferase class IV Malic_M PF03949.15 ADV25696.1 - 1.6e-85 286.5 0.0 2.1e-85 286.1 0.0 1.2 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 ADV25696.1 - 4.9e-63 212.2 0.0 6.9e-63 211.7 0.0 1.2 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain VPS11_C PF12451.8 ADV25697.1 - 3.4e-16 59.2 0.3 6.5e-16 58.3 0.3 1.5 1 0 0 1 1 1 1 Vacuolar protein sorting protein 11 C terminal Clathrin PF00637.20 ADV25697.1 - 5.4e-15 55.5 0.0 0.00018 21.4 0.0 3.6 3 1 0 3 3 3 3 Region in Clathrin and VPS zf-C3H2C3 PF17122.5 ADV25697.1 - 2.2e-07 30.8 7.5 3.7e-07 30.1 7.5 1.4 1 0 0 1 1 1 1 Zinc-finger zf-C3HC4_2 PF13923.6 ADV25697.1 - 0.0023 17.8 8.4 0.0039 17.0 8.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ADV25697.1 - 0.064 13.2 5.5 0.12 12.4 5.5 1.4 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_2 PF13639.6 ADV25697.1 - 0.085 13.2 7.2 0.16 12.4 7.2 1.5 1 0 0 1 1 1 0 Ring finger domain C1_1 PF00130.22 ADV25697.1 - 0.35 10.8 2.9 0.88 9.5 2.9 1.6 1 1 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING_UBOX PF13445.6 ADV25697.1 - 2.4 8.3 5.0 9.2 6.4 5.0 1.9 1 1 0 1 1 1 0 RING-type zinc-finger zf-rbx1 PF12678.7 ADV25697.1 - 3.2 8.1 5.8 7 7.0 5.8 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger domain Mito_carr PF00153.27 ADV25698.1 - 2.3e-42 142.8 7.7 3.5e-16 58.9 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein LEA_1 PF03760.15 ADV25698.1 - 0.32 11.7 3.3 0.98 10.1 3.6 1.6 1 1 0 1 1 1 0 Late embryogenesis abundant (LEA) group 1 TFIIA PF03153.13 ADV25700.1 - 1.8e-33 117.2 16.7 1e-26 94.9 13.2 2.0 1 1 1 2 2 2 2 Transcription factor IIA, alpha/beta subunit AAA_23 PF13476.6 ADV25701.1 - 4e-14 53.6 10.8 4e-14 53.6 10.8 8.3 2 2 1 3 3 3 1 AAA domain AAA_21 PF13304.6 ADV25701.1 - 9.9e-07 28.8 9.4 4.1e-05 23.5 0.0 3.7 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 ADV25701.1 - 1.4e-06 28.5 0.2 6.6e-06 26.3 0.0 2.4 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit OrsD PF12013.8 ADV25701.1 - 0.054 13.9 0.3 0.054 13.9 0.3 4.8 7 0 0 7 7 7 0 Orsellinic acid/F9775 biosynthesis cluster protein D Rot1 PF10681.9 ADV25701.1 - 3.3 7.2 4.4 8 5.9 1.5 2.7 2 0 0 2 2 2 0 Chaperone for protein-folding within the ER, fungal Cullin PF00888.22 ADV25702.1 - 4.3e-171 570.7 6.5 5.6e-171 570.3 6.5 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 ADV25702.1 - 2.8e-25 88.1 2.1 3.9e-25 87.7 0.5 2.1 2 0 0 2 2 2 1 Cullin protein neddylation domain Penicillinase_R PF03965.16 ADV25702.1 - 0.0031 17.9 5.6 12 6.3 0.0 4.8 4 2 2 6 6 6 3 Penicillinase repressor CHMI PF02962.15 ADV25702.1 - 0.027 14.8 0.1 0.062 13.6 0.1 1.6 1 0 0 1 1 1 0 5-carboxymethyl-2-hydroxymuconate isomerase Tfb2 PF03849.14 ADV25705.1 - 2.1e-92 309.8 0.1 4.4e-92 308.8 0.0 1.5 2 0 0 2 2 2 1 Transcription factor Tfb2 Tfb2_C PF18307.1 ADV25705.1 - 2.8e-15 56.5 0.1 8.2e-15 55.0 0.1 1.9 1 0 0 1 1 1 1 Transcription factor Tfb2 (p52) C-terminal domain Adeno_PV PF03910.13 ADV25708.1 - 2.9 6.5 10.2 3.5 6.2 10.2 1.1 1 0 0 1 1 1 0 Adenovirus minor core protein PV DUF1325 PF07039.11 ADV25709.1 - 8.6e-32 110.0 0.0 1.2e-31 109.5 0.0 1.2 1 0 0 1 1 1 1 SGF29 tudor-like domain TUDOR PF00567.24 ADV25709.1 - 0.024 14.7 0.2 6.3 6.8 0.0 2.9 2 1 1 3 3 3 0 Tudor domain BiPBP_C PF06832.12 ADV25709.1 - 0.14 12.2 0.1 1 9.4 0.0 2.4 2 2 0 2 2 2 0 Penicillin-Binding Protein C-terminus Family B12D PF06522.11 ADV25711.1 - 0.12 12.1 0.1 0.24 11.2 0.0 1.5 2 0 0 2 2 2 0 NADH-ubiquinone reductase complex 1 MLRQ subunit Cullin PF00888.22 ADV25713.1 - 4.1e-11 42.2 0.1 5e-11 41.9 0.1 1.0 1 0 0 1 1 1 1 Cullin family GAF_2 PF13185.6 ADV25714.1 - 1.3e-11 45.0 0.0 3.4e-11 43.6 0.0 1.7 1 1 0 1 1 1 1 GAF domain GAF PF01590.26 ADV25714.1 - 1.2e-07 32.5 0.0 1.5e-07 32.1 0.0 1.2 1 0 0 1 1 1 1 GAF domain GAF_3 PF13492.6 ADV25714.1 - 0.009 16.4 0.0 0.014 15.8 0.0 1.3 1 0 0 1 1 1 1 GAF domain Cyt-b5 PF00173.28 ADV25715.1 - 1.7e-19 69.7 0.0 2.7e-19 69.1 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain WD40 PF00400.32 ADV25716.1 - 3.4e-18 65.6 15.3 3.7e-05 24.4 0.6 6.8 7 0 0 7 7 7 5 WD domain, G-beta repeat F-box-like PF12937.7 ADV25716.1 - 6.1e-09 35.6 0.4 1.4e-08 34.5 0.4 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ADV25716.1 - 3.4e-06 26.8 0.4 7.7e-06 25.7 0.4 1.7 1 0 0 1 1 1 1 F-box domain ANAPC4_WD40 PF12894.7 ADV25716.1 - 0.062 13.6 0.1 22 5.4 0.0 3.7 3 1 1 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain RSN1_7TM PF02714.15 ADV25717.1 - 2.2e-76 256.8 17.5 2.2e-76 256.8 17.5 1.7 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 ADV25717.1 - 3.6e-32 111.3 0.4 3.6e-32 111.3 0.4 2.4 2 0 0 2 2 2 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 ADV25717.1 - 3.5e-14 53.4 0.0 1.1e-11 45.3 0.0 2.3 2 0 0 2 2 2 2 Cytosolic domain of 10TM putative phosphate transporter PHM7_ext PF12621.8 ADV25717.1 - 1.9e-13 50.4 0.0 3.7e-13 49.5 0.0 1.5 1 0 0 1 1 1 1 Extracellular tail, of 10TM putative phosphate transporter PgaD PF13994.6 ADV25717.1 - 0.24 11.5 3.2 6.9 6.7 0.3 2.7 2 0 0 2 2 2 0 PgaD-like protein GNAT_acetyltr_2 PF13718.6 ADV25718.1 - 2.9e-89 298.4 0.0 6.9e-89 297.1 0.0 1.7 1 0 0 1 1 1 1 GNAT acetyltransferase 2 tRNA_bind_2 PF13725.6 ADV25718.1 - 1.1e-69 234.7 0.1 1.9e-69 234.0 0.1 1.4 1 0 0 1 1 1 1 Possible tRNA binding domain Helicase_RecD PF05127.14 ADV25718.1 - 8.8e-64 214.6 0.0 2.1e-63 213.4 0.0 1.7 1 0 0 1 1 1 1 Helicase DUF1726 PF08351.11 ADV25718.1 - 1.2e-31 108.5 0.0 3.2e-31 107.1 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1726) Acetyltransf_1 PF00583.25 ADV25718.1 - 0.027 14.7 0.0 0.066 13.5 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ADV25718.1 - 0.039 14.4 0.0 0.13 12.7 0.0 1.9 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain AAA_22 PF13401.6 ADV25718.1 - 0.071 13.4 0.0 2.9 8.2 0.0 2.7 2 0 0 2 2 2 0 AAA domain HORMA PF02301.18 ADV25719.1 - 0.0037 16.9 0.0 0.0048 16.5 0.0 1.3 1 0 0 1 1 1 1 HORMA domain TIR-like PF10137.9 ADV25719.1 - 0.049 13.6 0.0 1 9.4 0.0 2.2 2 0 0 2 2 2 0 Predicted nucleotide-binding protein containing TIR-like domain Amidohydro_1 PF01979.20 ADV25720.1 - 3.7e-40 138.3 0.0 4.8e-39 134.6 0.0 1.9 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 ADV25720.1 - 0.0019 17.8 0.0 0.0082 15.6 0.0 1.8 2 0 0 2 2 2 1 Amidohydrolase family A_deaminase PF00962.22 ADV25720.1 - 0.01 15.2 0.0 0.022 14.1 0.0 1.5 1 0 0 1 1 1 0 Adenosine/AMP deaminase zf-U1 PF06220.12 ADV25721.1 - 3.6e-11 42.6 0.4 6e-11 41.9 0.4 1.4 1 0 0 1 1 1 1 U1 zinc finger DUF3446 PF11928.8 ADV25721.1 - 0.54 10.6 7.5 1.3 9.4 7.5 1.6 1 0 0 1 1 1 0 Early growth response N-terminal domain Pkinase PF00069.25 ADV25722.1 - 2.1e-13 50.3 0.0 3.4e-13 49.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV25722.1 - 2e-05 24.0 0.0 2.6e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RPN6_N PF18055.1 ADV25723.1 - 2.4e-39 134.3 0.6 2.4e-39 134.3 0.6 1.9 2 0 0 2 2 2 1 26S proteasome regulatory subunit RPN6 N-terminal domain PCI PF01399.27 ADV25723.1 - 1.7e-11 44.5 0.5 1.7e-11 44.5 0.5 2.0 2 0 0 2 2 2 1 PCI domain TPR_MalT PF17874.1 ADV25723.1 - 0.00061 19.3 2.9 0.0011 18.5 2.9 1.4 1 0 0 1 1 1 1 MalT-like TPR region mRNA_stabil PF13929.6 ADV25723.1 - 0.023 13.7 5.0 0.019 13.9 3.0 1.9 1 1 1 2 2 2 0 mRNA stabilisation RPN6_C_helix PF18503.1 ADV25723.1 - 0.025 14.3 0.1 0.05 13.3 0.1 1.5 1 0 0 1 1 1 0 26S proteasome subunit RPN6 C-terminal helix domain Peptidase_S28 PF05577.12 ADV25723.1 - 0.026 13.3 0.0 0.042 12.6 0.0 1.3 1 0 0 1 1 1 0 Serine carboxypeptidase S28 FdhE PF04216.12 ADV25723.1 - 0.04 13.8 1.3 0.065 13.1 1.3 1.4 1 0 0 1 1 1 0 Protein involved in formate dehydrogenase formation TPR_19 PF14559.6 ADV25723.1 - 0.11 13.1 3.7 14 6.3 0.0 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat MIT PF04212.18 ADV25723.1 - 0.51 10.5 5.9 2.8 8.1 0.4 3.4 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain TPR_12 PF13424.6 ADV25723.1 - 0.62 10.4 7.8 1.7 9.0 0.2 3.9 4 1 0 4 4 4 0 Tetratricopeptide repeat ADH_N PF08240.12 ADV25724.1 - 6.2e-30 103.3 1.0 1e-29 102.6 1.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ADV25724.1 - 3.3e-15 56.2 0.2 6.5e-15 55.3 0.2 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 ADV25724.1 - 0.00015 21.3 0.3 0.00021 20.8 0.3 1.2 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_N_assoc PF13823.6 ADV25724.1 - 0.00065 19.6 0.4 0.0012 18.8 0.4 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-associated AlaDh_PNT_C PF01262.21 ADV25724.1 - 0.011 15.0 0.4 0.019 14.3 0.4 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain ADH_zinc_N_2 PF13602.6 ADV25724.1 - 0.024 15.7 0.1 0.045 14.8 0.1 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase DcpS_C PF11969.8 ADV25725.1 - 1.6e-31 109.1 0.0 3.2e-31 108.2 0.0 1.5 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding DcpS PF05652.12 ADV25725.1 - 5.6e-18 65.7 0.0 9.9e-18 64.9 0.0 1.4 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme (DcpS) N-terminal Iwr1 PF08574.10 ADV25726.1 - 3.2e-08 34.5 13.8 3.2e-08 34.5 13.8 3.5 2 1 1 3 3 3 1 Transcription factor Iwr1 CoA_binding_2 PF13380.6 ADV25727.1 - 1.6e-16 60.9 0.0 1.8e-16 60.7 0.0 1.1 1 0 0 1 1 1 1 CoA binding domain CAP_GLY PF01302.25 ADV25729.1 - 9.5e-20 70.4 2.6 1.7e-19 69.6 2.6 1.4 1 0 0 1 1 1 1 CAP-Gly domain Filament PF00038.21 ADV25729.1 - 1.3e-05 24.9 11.4 1.3e-05 24.9 11.4 5.5 1 1 3 4 4 2 1 Intermediate filament protein DHR10 PF18595.1 ADV25729.1 - 0.00078 19.5 6.7 0.00078 19.5 6.7 7.2 3 2 4 7 7 6 2 Designed helical repeat protein 10 domain Fez1 PF06818.15 ADV25729.1 - 0.0011 19.4 13.8 0.0011 19.4 13.8 4.7 1 1 4 5 5 5 1 Fez1 Spectrin PF00435.21 ADV25729.1 - 0.0043 17.5 7.4 0.0043 17.5 7.4 5.7 4 1 1 5 5 5 1 Spectrin repeat CENP-F_leu_zip PF10473.9 ADV25729.1 - 0.005 16.9 14.9 0.005 16.9 14.9 6.2 2 2 4 6 6 6 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GAS PF13851.6 ADV25729.1 - 0.0056 16.1 4.7 0.0056 16.1 4.7 5.4 1 1 3 5 5 5 2 Growth-arrest specific micro-tubule binding Spc7 PF08317.11 ADV25729.1 - 0.0063 15.4 97.8 0.0064 15.4 13.0 5.1 1 1 4 5 5 5 2 Spc7 kinetochore protein HIP1_clath_bdg PF16515.5 ADV25729.1 - 0.0063 17.1 13.4 0.0063 17.1 13.4 8.0 1 1 8 9 9 9 1 Clathrin-binding domain of Huntingtin-interacting protein 1 ATG16 PF08614.11 ADV25729.1 - 0.0069 16.6 17.6 0.0069 16.6 17.6 5.9 1 1 5 6 6 6 3 Autophagy protein 16 (ATG16) TSC22 PF01166.18 ADV25729.1 - 0.018 15.3 0.3 0.018 15.3 0.3 10.1 9 3 1 10 10 9 0 TSC-22/dip/bun family tRNA-synt_2 PF00152.20 ADV25729.1 - 0.83 8.7 4.1 1.3 8.0 4.1 1.4 1 0 0 1 1 1 0 tRNA synthetases class II (D, K and N) MAD PF05557.13 ADV25729.1 - 1.4 7.1 90.3 0.016 13.6 30.3 3.5 1 1 2 3 3 2 0 Mitotic checkpoint protein TPR_MLP1_2 PF07926.12 ADV25729.1 - 1.5 8.9 108.7 0.49 10.5 17.3 6.7 1 1 4 6 6 6 0 TPR/MLP1/MLP2-like protein BRI3BP PF14965.6 ADV25729.1 - 2.4 7.6 11.9 22 4.5 0.0 4.4 4 0 0 4 4 4 0 Negative regulator of p53/TP53 SlyX PF04102.12 ADV25729.1 - 5.5 7.7 62.6 1.1 9.9 2.0 9.8 3 2 7 11 11 11 0 SlyX DUF4407 PF14362.6 ADV25729.1 - 10 5.4 79.6 0.7 9.2 20.2 4.8 1 1 3 4 4 4 0 Domain of unknown function (DUF4407) Methyltransf_16 PF10294.9 ADV25730.1 - 5.9e-09 35.9 0.0 3e-07 30.3 0.0 2.4 1 1 0 1 1 1 1 Lysine methyltransferase Methyltransf_25 PF13649.6 ADV25730.1 - 0.016 15.9 0.1 8.6 7.2 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase domain DPBB_1 PF03330.18 ADV25731.1 - 0.00016 21.9 0.2 0.00026 21.2 0.2 1.4 1 1 0 1 1 1 1 Lytic transglycolase Barwin PF00967.17 ADV25731.1 - 0.0073 16.1 0.1 0.0082 16.0 0.1 1.3 1 0 0 1 1 1 1 Barwin family PADR1 PF08063.12 ADV25731.1 - 0.069 12.9 0.0 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 PADR1 (NUC008) domain DPBB_1 PF03330.18 ADV25732.1 - 2.9e-06 27.5 0.8 7.6e-06 26.1 0.0 1.8 2 0 0 2 2 2 1 Lytic transglycolase Barwin PF00967.17 ADV25732.1 - 0.02 14.7 1.3 0.084 12.7 0.1 2.2 1 1 1 2 2 2 0 Barwin family MDM10 PF12519.8 ADV25733.1 - 5.1e-93 312.5 0.0 6e-93 312.2 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial distribution and morphology protein 10 Porin_3 PF01459.22 ADV25733.1 - 0.0067 15.9 0.0 1.2 8.5 0.0 2.4 3 0 0 3 3 3 2 Eukaryotic porin SH3_2 PF07653.17 ADV25733.1 - 0.021 14.5 0.3 0.041 13.6 0.3 1.5 1 0 0 1 1 1 0 Variant SH3 domain Med31 PF05669.12 ADV25734.1 - 6.3e-32 109.4 0.6 8.4e-32 109.0 0.6 1.1 1 0 0 1 1 1 1 SOH1 Zn_clus PF00172.18 ADV25736.1 - 3.1e-06 27.2 8.9 5.6e-06 26.4 8.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4381 PF14316.6 ADV25736.1 - 0.038 14.2 0.0 0.08 13.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) ABC2_membrane PF01061.24 ADV25737.1 - 2.2e-47 161.2 57.9 4.6e-35 121.0 16.6 3.5 4 0 0 4 4 4 2 ABC-2 type transporter ABC_tran PF00005.27 ADV25737.1 - 1.7e-37 129.0 0.3 7.1e-20 71.9 0.0 2.6 3 0 0 3 3 2 2 ABC transporter PDR_CDR PF06422.12 ADV25737.1 - 1.3e-23 82.7 0.1 1.3e-23 82.7 0.1 3.6 4 0 0 4 4 2 2 CDR ABC transporter ABC2_membrane_3 PF12698.7 ADV25737.1 - 4.7e-08 32.5 9.8 4.7e-08 32.5 9.8 3.2 3 1 0 3 3 3 1 ABC-2 family transporter protein AAA_21 PF13304.6 ADV25737.1 - 2.8e-07 30.6 0.0 0.034 14.0 0.0 3.2 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 ADV25737.1 - 6.3e-07 29.9 0.1 0.0025 18.2 0.1 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 ADV25737.1 - 4.5e-06 26.3 1.8 0.018 14.8 2.2 2.9 2 1 1 3 3 3 2 P-loop containing region of AAA domain AAA_25 PF13481.6 ADV25737.1 - 8e-06 25.6 1.6 0.0023 17.5 0.7 2.6 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 ADV25737.1 - 7.6e-05 22.7 0.2 0.0071 16.3 0.1 2.5 2 0 0 2 2 2 1 RsgA GTPase AAA_22 PF13401.6 ADV25737.1 - 0.00052 20.3 0.1 0.45 10.8 0.1 2.7 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 ADV25737.1 - 0.0017 18.5 0.1 1.4 9.0 0.0 3.1 3 0 0 3 3 2 1 50S ribosome-binding GTPase AAA_30 PF13604.6 ADV25737.1 - 0.0027 17.5 0.1 2 8.1 0.1 2.3 2 0 0 2 2 2 2 AAA domain ABC_trans_N PF14510.6 ADV25737.1 - 0.014 16.0 0.1 0.056 14.1 0.1 2.1 1 0 0 1 1 1 0 ABC-transporter N-terminal AAA_23 PF13476.6 ADV25737.1 - 0.034 14.6 4.2 0.038 14.5 0.0 2.9 4 0 0 4 4 4 0 AAA domain AAA_18 PF13238.6 ADV25737.1 - 0.034 14.7 0.1 19 5.8 0.0 3.2 3 0 0 3 3 3 0 AAA domain NACHT PF05729.12 ADV25737.1 - 0.035 14.0 0.8 0.65 9.9 0.3 2.3 2 0 0 2 2 2 0 NACHT domain Ploopntkinase3 PF18751.1 ADV25737.1 - 0.056 13.4 0.0 0.97 9.3 0.0 2.6 3 0 0 3 3 2 0 P-loop Nucleotide Kinase3 AAA_28 PF13521.6 ADV25737.1 - 0.066 13.4 2.5 6.5 7.0 1.3 2.8 2 1 0 2 2 2 0 AAA domain HalX PF08663.10 ADV25737.1 - 0.091 13.1 1.2 0.19 12.0 1.2 1.5 1 0 0 1 1 1 0 HalX domain Retrotrans_gag PF03732.17 ADV25737.1 - 0.23 11.8 0.6 0.66 10.3 0.6 1.7 1 0 0 1 1 1 0 Retrotransposon gag protein cobW PF02492.19 ADV25737.1 - 0.45 10.1 1.4 2.5 7.7 0.9 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain GRA6 PF05084.13 ADV25739.1 - 0.0018 18.3 0.1 0.0024 17.9 0.1 1.2 1 0 0 1 1 1 1 Granule antigen protein (GRA6) DUF3040 PF11239.8 ADV25739.1 - 0.0092 16.2 0.1 0.016 15.4 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3040) Fusion_gly PF00523.18 ADV25739.1 - 0.051 11.8 0.0 0.079 11.2 0.0 1.2 1 0 0 1 1 1 0 Fusion glycoprotein F0 ETRAMP PF09716.10 ADV25739.1 - 0.059 13.4 0.0 0.083 13.0 0.0 1.3 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) ArsP_2 PF11449.8 ADV25739.1 - 0.074 12.2 0.0 0.11 11.7 0.0 1.2 1 0 0 1 1 1 0 Putative, 10TM heavy-metal exporter Zip PF02535.22 ADV25739.1 - 0.093 11.9 0.0 0.14 11.3 0.0 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Glyco_hydro_17 PF00332.18 ADV25740.1 - 2.9e-09 37.0 4.5 1.8e-08 34.4 3.7 2.3 1 1 0 1 1 1 1 Glycosyl hydrolases family 17 DHquinase_II PF01220.19 ADV25740.1 - 0.069 12.8 1.5 0.67 9.6 0.1 2.2 1 1 1 2 2 2 0 Dehydroquinase class II Ric8 PF10165.9 ADV25742.1 - 1.1e-88 298.3 0.0 6.2e-88 295.9 0.0 1.8 1 1 0 1 1 1 1 Guanine nucleotide exchange factor synembryn Dehydrin PF00257.19 ADV25742.1 - 0.0064 17.1 0.9 0.014 16.0 0.9 1.6 1 0 0 1 1 1 1 Dehydrin Dcc1 PF09724.9 ADV25745.1 - 1e-72 245.2 0.0 1.2e-72 245.0 0.0 1.0 1 0 0 1 1 1 1 Sister chromatid cohesion protein Dcc1 CLP_protease PF00574.23 ADV25746.1 - 5.1e-73 244.9 0.0 6.6e-73 244.5 0.0 1.1 1 0 0 1 1 1 1 Clp protease Glyco_hydro_71 PF03659.14 ADV25747.1 - 4.9e-119 397.5 9.3 4.9e-119 397.5 9.3 1.4 2 0 0 2 2 2 1 Glycosyl hydrolase family 71 RRN9 PF10680.9 ADV25747.1 - 0.71 10.2 2.9 18 5.7 0.1 2.4 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor DUF4592 PF15262.6 ADV25747.1 - 0.8 10.4 4.9 1.8 9.2 4.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4592) Pet191_N PF10203.9 ADV25748.1 - 0.0025 18.1 2.2 0.0035 17.6 2.2 1.3 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein PET191 MTCP1 PF08991.10 ADV25748.1 - 0.0025 18.0 1.6 0.0033 17.6 1.6 1.2 1 0 0 1 1 1 1 Mature-T-Cell Proliferation I type CHCH PF06747.13 ADV25748.1 - 0.016 15.3 3.1 0.023 14.8 3.1 1.2 1 0 0 1 1 1 0 CHCH domain E1-E2_ATPase PF00122.20 ADV25749.1 - 1.6e-50 171.1 1.7 1.6e-50 171.1 1.7 2.2 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 ADV25749.1 - 6.5e-35 121.3 1.1 1.4e-34 120.2 1.1 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 ADV25749.1 - 3.1e-12 46.8 0.2 2.4e-11 43.9 0.0 2.4 2 0 0 2 2 2 1 Heavy-metal-associated domain Hydrolase_3 PF08282.12 ADV25749.1 - 6.4e-06 26.1 0.3 0.0036 17.1 0.1 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 ADV25749.1 - 0.1 12.7 0.0 0.35 11.0 0.0 1.9 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase HAD PF12710.7 ADV25749.1 - 0.18 12.2 0.0 0.4 11.0 0.0 1.5 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Clat_adaptor_s PF01217.20 ADV25750.1 - 7.1e-30 103.8 0.0 1.5e-29 102.8 0.0 1.5 1 1 0 1 1 1 1 Clathrin adaptor complex small chain PP2C PF00481.21 ADV25751.1 - 1.7e-42 145.9 0.0 1.3e-35 123.3 0.0 2.1 1 1 1 2 2 2 2 Protein phosphatase 2C Mito_carr PF00153.27 ADV25752.1 - 1e-60 201.7 3.9 3.8e-21 74.8 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 ADV25752.1 - 1.6 7.8 6.0 3.1 6.9 0.2 3.6 1 1 2 4 4 4 0 Gammaproteobacterial serine protease GPI-anchored PF10342.9 ADV25753.1 - 1.6e-08 35.2 0.4 1.6e-08 35.2 0.4 2.4 2 1 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Macoilin PF09726.9 ADV25753.1 - 1.9 6.9 5.6 2.1 6.8 5.6 1.0 1 0 0 1 1 1 0 Macoilin family RAP1 PF07218.11 ADV25753.1 - 5.2 5.2 13.8 6.1 5.0 13.8 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Pilin PF00114.19 ADV25753.1 - 7.4 7.6 12.2 8.5 7.4 0.1 2.3 2 0 0 2 2 2 0 Pilin (bacterial filament) LSM PF01423.22 ADV25754.1 - 2.2e-17 62.5 0.0 2.5e-17 62.3 0.0 1.0 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 ADV25754.1 - 4e-05 23.7 0.0 4.8e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM14 PF12701.7 ADV25754.1 - 0.0025 17.9 0.0 0.0033 17.5 0.0 1.4 1 1 0 1 1 1 1 Scd6-like Sm domain Mus7 PF09462.10 ADV25756.1 - 3.5e-50 171.5 0.0 7.4e-50 170.4 0.0 1.5 1 1 0 1 1 1 1 Mus7/MMS22 family Acetate_kinase PF00871.17 ADV25757.1 - 1.2e-87 294.1 0.0 1.5e-87 293.9 0.0 1.0 1 0 0 1 1 1 1 Acetokinase family DUF4777 PF16007.5 ADV25757.1 - 0.059 13.6 0.0 2.1 8.6 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4777) AMP-binding PF00501.28 ADV25758.1 - 5.5e-100 334.9 0.0 6.8e-100 334.6 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ADV25758.1 - 8.2e-13 49.1 0.0 1.6e-12 48.2 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Dfp1_Him1_M PF08630.10 ADV25759.1 - 1.7e-24 86.4 0.6 1.2e-23 83.8 0.6 2.3 1 1 0 1 1 1 1 Dfp1/Him1, central region zf-DBF PF07535.12 ADV25759.1 - 2.2e-18 66.1 0.1 3.3e-18 65.5 0.1 1.3 1 0 0 1 1 1 1 DBF zinc finger PTCB-BRCT PF12738.7 ADV25759.1 - 0.031 14.2 0.0 0.085 12.8 0.0 1.7 1 0 0 1 1 1 0 twin BRCT domain RcnB PF11776.8 ADV25759.1 - 0.042 13.9 0.0 0.09 12.9 0.0 1.5 1 0 0 1 1 1 0 Nickel/cobalt transporter regulator BRCT PF00533.26 ADV25759.1 - 0.059 13.8 0.0 0.13 12.7 0.0 1.6 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain Peptidase_M50B PF13398.6 ADV25760.1 - 5.2e-23 81.7 10.7 1.5e-18 67.2 5.2 2.0 1 1 0 2 2 2 2 Peptidase M50B-like ALO PF04030.14 ADV25761.1 - 5.5e-82 275.5 0.2 8.9e-82 274.8 0.0 1.4 2 0 0 2 2 2 1 D-arabinono-1,4-lactone oxidase FAD_binding_4 PF01565.23 ADV25761.1 - 1.8e-21 76.3 0.0 3.2e-21 75.5 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain tRNA-synt_1 PF00133.22 ADV25762.1 - 1.1e-149 499.5 0.0 1.3e-149 499.2 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 ADV25762.1 - 3.8e-31 108.1 0.2 9.9e-31 106.8 0.2 1.8 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 ADV25762.1 - 6.4e-22 77.8 0.3 2.2e-12 46.5 0.1 3.6 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 ADV25762.1 - 4e-05 23.1 0.0 0.058 12.7 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 ADV25762.1 - 0.00036 19.6 0.0 0.0011 18.0 0.0 1.7 2 0 0 2 2 2 1 tRNA synthetases class I (K) DUF3376 PF11856.8 ADV25762.1 - 0.13 11.3 0.0 0.25 10.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3376) bZIP_1 PF00170.21 ADV25763.1 - 1.6e-12 47.3 14.0 2e-10 40.6 6.9 2.2 2 0 0 2 2 2 2 bZIP transcription factor bZIP_2 PF07716.15 ADV25763.1 - 1.8e-11 43.9 16.4 6e-10 39.1 7.4 2.5 2 0 0 2 2 2 2 Basic region leucine zipper Nnf1 PF03980.14 ADV25763.1 - 6e-06 26.6 3.1 0.0016 18.8 1.1 2.3 2 0 0 2 2 2 2 Nnf1 ZapB PF06005.12 ADV25763.1 - 0.00034 21.0 9.1 0.0018 18.7 2.0 2.3 2 0 0 2 2 2 1 Cell division protein ZapB bZIP_Maf PF03131.17 ADV25763.1 - 0.0023 18.4 5.7 0.0023 18.4 5.7 2.3 2 0 0 2 2 2 1 bZIP Maf transcription factor HAP1_N PF04849.13 ADV25763.1 - 0.0081 15.4 7.1 0.074 12.2 1.9 2.1 2 0 0 2 2 2 1 HAP1 N-terminal conserved region GIT_CC PF16559.5 ADV25763.1 - 0.0086 15.9 0.4 0.43 10.5 0.1 2.3 2 0 0 2 2 2 1 GIT coiled-coil Rho guanine nucleotide exchange factor Filament PF00038.21 ADV25763.1 - 0.015 14.9 3.7 0.9 9.1 0.2 2.1 2 0 0 2 2 2 0 Intermediate filament protein DUF4140 PF13600.6 ADV25763.1 - 0.022 15.2 0.5 4.1 7.9 0.0 2.3 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Fez1 PF06818.15 ADV25763.1 - 0.03 14.8 6.7 0.043 14.3 6.7 1.2 1 0 0 1 1 1 0 Fez1 JAKMIP_CC3 PF16034.5 ADV25763.1 - 0.045 13.7 4.0 0.39 10.6 0.9 2.3 2 0 0 2 2 2 0 JAKMIP CC3 domain DUF5082 PF16888.5 ADV25763.1 - 0.17 12.1 4.8 0.53 10.6 4.8 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF5082) YabA PF06156.13 ADV25763.1 - 0.34 11.6 5.9 0.4 11.3 0.6 2.2 2 0 0 2 2 2 0 Initiation control protein YabA KIAA1430 PF13879.6 ADV25763.1 - 0.43 11.4 9.7 3.1 8.6 6.4 2.6 1 1 2 3 3 3 0 KIAA1430 homologue TSC22 PF01166.18 ADV25763.1 - 0.59 10.5 3.7 7.4 7.0 0.3 2.4 2 0 0 2 2 2 0 TSC-22/dip/bun family DUF5595 PF18077.1 ADV25763.1 - 0.68 10.1 4.8 0.59 10.2 1.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5595) DUF4407 PF14362.6 ADV25763.1 - 0.77 9.0 3.0 1.8 7.8 3.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Tmemb_cc2 PF10267.9 ADV25763.1 - 0.78 8.8 8.7 3.9 6.5 8.8 1.7 1 1 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein K-box PF01486.17 ADV25763.1 - 0.82 9.9 7.8 1.6 8.9 1.1 2.3 2 0 0 2 2 2 0 K-box region DivIC PF04977.15 ADV25763.1 - 1 9.2 6.4 1.1 9.1 0.5 2.2 2 0 0 2 2 2 0 Septum formation initiator OmpH PF03938.14 ADV25763.1 - 1.1 9.6 4.4 3.8 7.8 1.1 2.1 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) UPF0242 PF06785.11 ADV25763.1 - 1.3 9.1 10.9 3 7.9 1.4 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus GBP_C PF02841.14 ADV25763.1 - 1.4 8.2 7.2 0.13 11.6 1.0 1.9 2 0 0 2 2 2 0 Guanylate-binding protein, C-terminal domain Rootletin PF15035.6 ADV25763.1 - 1.5 8.8 13.2 6.5 6.7 12.0 2.0 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion Jnk-SapK_ap_N PF09744.9 ADV25763.1 - 1.6 9.0 9.0 6.3 7.0 1.6 2.2 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 Spc24 PF08286.11 ADV25763.1 - 1.9 8.8 4.9 19 5.6 0.7 2.3 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 Med21 PF11221.8 ADV25763.1 - 2.1 8.6 7.1 1.1 9.5 0.8 2.6 2 0 0 2 2 2 0 Subunit 21 of Mediator complex UPF0184 PF03670.13 ADV25763.1 - 2.2 8.7 6.6 19 5.7 0.2 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0184) SlyX PF04102.12 ADV25763.1 - 2.7 8.6 7.2 3.1 8.5 1.0 2.6 2 1 0 2 2 2 0 SlyX PSK_trans_fac PF07704.11 ADV25763.1 - 4 8.3 9.2 1.3 9.9 3.0 2.2 2 0 0 2 2 2 0 Rv0623-like transcription factor DMPK_coil PF08826.10 ADV25763.1 - 5.7 7.1 11.6 9.3 6.5 4.3 2.2 2 0 0 2 2 2 0 DMPK coiled coil domain like APG6_N PF17675.1 ADV25763.1 - 6.4 7.3 15.5 1.5 9.3 5.9 2.1 1 1 0 2 2 2 0 Apg6 coiled-coil region ADIP PF11559.8 ADV25763.1 - 7.4 6.6 9.5 2 8.5 0.7 2.2 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding SPC22 PF04573.12 ADV25764.1 - 1.5e-31 109.2 0.0 3.9e-31 107.8 0.0 1.6 1 1 0 1 1 1 1 Signal peptidase subunit RcsD_ABL PF16359.5 ADV25764.1 - 0.13 12.4 0.2 1.5 9.0 0.0 2.1 1 1 1 2 2 2 0 RcsD-ABL domain Pkinase PF00069.25 ADV25765.1 - 2.2e-68 230.5 0.0 2.7e-68 230.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV25765.1 - 5.1e-34 117.7 0.0 7.1e-34 117.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ADV25765.1 - 2.2e-05 24.0 0.0 3.2e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 ADV25765.1 - 0.0019 17.2 0.1 0.012 14.6 0.1 1.9 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 ADV25765.1 - 0.016 14.6 0.1 0.046 13.1 0.1 1.6 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ADV25765.1 - 0.019 14.9 0.1 0.044 13.7 0.1 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 ADV25765.1 - 0.064 12.3 0.0 0.1 11.7 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 zf-Mss51 PF13824.6 ADV25766.1 - 1.3e-20 73.2 6.6 2.3e-20 72.4 6.6 1.4 1 0 0 1 1 1 1 Zinc-finger of mitochondrial splicing suppressor 51 Usp PF00582.26 ADV25768.1 - 2.5e-20 73.4 0.0 2.5e-20 73.4 0.0 2.4 3 0 0 3 3 3 1 Universal stress protein family YqgB PF11036.8 ADV25768.1 - 0.2 11.4 0.1 0.45 10.3 0.1 1.6 1 0 0 1 1 1 0 Virulence promoting factor NuA4 PF09340.10 ADV25769.1 - 5.1e-11 42.3 0.1 7.7e-11 41.7 0.1 1.2 1 0 0 1 1 1 1 Histone acetyltransferase subunit NuA4 RIO1 PF01163.22 ADV25770.1 - 1.9e-62 210.2 0.0 1.9e-62 210.2 0.0 2.0 2 0 0 2 2 2 1 RIO1 family Pkinase PF00069.25 ADV25770.1 - 0.0007 19.0 0.1 0.0015 17.9 0.1 1.5 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 ADV25770.1 - 0.12 12.3 3.2 0.44 10.4 1.3 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family MID_MedPIWI PF18296.1 ADV25770.1 - 1.5 8.5 7.5 0.33 10.7 0.1 2.2 2 0 0 2 2 2 0 MID domain of medPIWI PPR_3 PF13812.6 ADV25771.1 - 9.9e-29 99.2 0.0 3.5e-09 36.6 0.1 6.3 6 0 0 6 6 6 4 Pentatricopeptide repeat domain PPR_2 PF13041.6 ADV25771.1 - 8.8e-18 64.2 0.1 0.00039 20.6 0.2 6.2 2 1 4 6 6 6 5 PPR repeat family PPR_long PF17177.4 ADV25771.1 - 7.7e-14 51.6 0.1 0.0013 18.1 0.0 4.4 1 1 2 4 4 4 4 Pentacotripeptide-repeat region of PRORP PPR PF01535.20 ADV25771.1 - 1.4e-06 28.2 0.3 1.5 9.2 0.0 6.7 8 0 0 8 8 8 1 PPR repeat Vps23_core PF09454.10 ADV25771.1 - 0.016 15.2 0.2 7 6.7 0.0 2.9 3 0 0 3 3 3 0 Vps23 core domain PPR_1 PF12854.7 ADV25771.1 - 0.031 14.0 4.7 8.6 6.2 0.0 4.5 4 0 0 4 4 4 0 PPR repeat YTH PF04146.15 ADV25772.1 - 8.2e-57 191.8 0.6 2.5e-56 190.2 0.6 1.8 1 1 0 1 1 1 1 YT521-B-like domain RRM_1 PF00076.22 ADV25772.1 - 0.0018 18.1 0.0 0.71 9.7 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SH3_4 PF06347.13 ADV25773.1 - 0.091 12.6 0.0 0.28 11.0 0.0 1.8 1 0 0 1 1 1 0 Bacterial SH3 domain Fasciclin PF02469.22 ADV25774.1 - 8.2e-59 197.4 0.0 9e-18 64.7 0.0 7.2 8 0 0 8 8 8 6 Fasciclin domain ORMDL PF04061.14 ADV25775.1 - 4.9e-53 178.6 1.0 6.2e-53 178.3 1.0 1.1 1 0 0 1 1 1 1 ORMDL family TspO_MBR PF03073.15 ADV25776.1 - 1.3e-42 145.1 7.0 1.5e-42 144.9 7.0 1.0 1 0 0 1 1 1 1 TspO/MBR family Nuc_sug_transp PF04142.15 ADV25777.1 - 5.4e-08 32.4 0.1 1e-07 31.5 0.1 1.5 1 0 0 1 1 1 1 Nucleotide-sugar transporter UAA PF08449.11 ADV25777.1 - 5.4e-07 29.1 9.1 9.5e-07 28.3 9.1 1.3 1 0 0 1 1 1 1 UAA transporter family TPT PF03151.16 ADV25777.1 - 1.2e-06 28.1 7.7 0.00032 20.1 0.4 2.1 2 0 0 2 2 2 2 Triose-phosphate Transporter family EamA PF00892.20 ADV25777.1 - 2.4e-05 24.5 25.1 0.00022 21.4 4.2 2.6 2 0 0 2 2 2 2 EamA-like transporter family WBS28 PF15164.6 ADV25777.1 - 0.02 14.2 1.9 0.033 13.5 1.9 1.3 1 0 0 1 1 1 0 Williams-Beuren syndrome chromosomal region 28 protein homologue Git3 PF11710.8 ADV25778.1 - 0.024 14.4 1.7 0.024 14.4 1.7 2.4 3 1 0 3 3 3 0 G protein-coupled glucose receptor regulating Gpa2 Cys_Met_Meta_PP PF01053.20 ADV25779.1 - 1.2e-93 313.8 0.0 2.2e-64 217.4 0.0 2.1 2 0 0 2 2 2 2 Cys/Met metabolism PLP-dependent enzyme Ribosomal_L22 PF00237.19 ADV25780.1 - 1.1e-37 128.4 0.2 1.6e-37 127.9 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e RE_Eco29kI PF09517.10 ADV25780.1 - 0.12 12.0 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 Eco29kI restriction endonuclease HSP70 PF00012.20 ADV25781.1 - 8.2e-258 856.5 7.3 1e-257 856.2 7.3 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 ADV25781.1 - 1.1e-17 63.9 0.8 2.3e-16 59.5 0.2 2.2 2 0 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.6 ADV25781.1 - 0.004 17.5 0.3 8.7 6.8 0.0 3.3 3 0 0 3 3 3 2 Cell division protein FtsA DDR PF08841.10 ADV25781.1 - 0.0085 15.1 0.7 0.25 10.3 0.5 2.3 2 0 0 2 2 2 1 Diol dehydratase reactivase ATPase-like domain Ppx-GppA PF02541.16 ADV25781.1 - 0.021 14.2 0.2 0.061 12.7 0.2 1.8 1 0 0 1 1 1 0 Ppx/GppA phosphatase family Hydantoinase_A PF01968.18 ADV25781.1 - 0.11 11.8 4.4 0.43 9.8 0.2 2.9 3 0 0 3 3 3 0 Hydantoinase/oxoprolinase Syntaxin-6_N PF09177.11 ADV25781.1 - 0.21 12.1 1.3 2.3 8.8 0.1 2.5 2 0 0 2 2 2 0 Syntaxin 6, N-terminal ABC_membrane_2 PF06472.15 ADV25781.1 - 0.33 10.3 1.0 0.58 9.5 0.1 1.7 2 0 0 2 2 2 0 ABC transporter transmembrane region 2 SNF2_N PF00176.23 ADV25782.1 - 1e-32 113.3 0.2 3.7e-32 111.4 0.2 1.9 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ADV25782.1 - 1.1e-13 51.5 0.2 3.9e-13 49.7 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ADV25782.1 - 0.0025 17.8 0.1 0.019 15.0 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SEC-C PF02810.15 ADV25782.1 - 0.0097 15.8 5.0 0.018 15.0 5.0 1.5 1 0 0 1 1 1 1 SEC-C motif Acyl-CoA_dh_1 PF00441.24 ADV25785.1 - 6e-47 159.6 1.5 9.9e-47 158.9 1.5 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 ADV25785.1 - 3.1e-27 95.5 0.0 9.4e-27 93.9 0.0 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 ADV25785.1 - 1.7e-22 79.4 0.0 3.1e-22 78.6 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 ADV25785.1 - 8.5e-22 77.9 0.1 1.3e-21 77.3 0.1 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Cas1_AcylT PF07779.12 ADV25786.1 - 5.2e-132 441.1 12.1 8e-132 440.5 12.1 1.1 1 0 0 1 1 1 1 10 TM Acyl Transferase domain found in Cas1p HSP20 PF00011.21 ADV25787.1 - 0.013 15.7 0.0 0.028 14.6 0.0 1.5 1 1 0 1 1 1 0 Hsp20/alpha crystallin family Fungal_trans PF04082.18 ADV25788.1 - 1.9e-21 76.3 0.0 3.2e-21 75.6 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ADV25788.1 - 1.3e-08 34.8 10.4 2.3e-08 34.0 10.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SUR7 PF06687.12 ADV25789.1 - 3.2e-25 89.0 7.3 4e-25 88.7 7.3 1.1 1 0 0 1 1 1 1 SUR7/PalI family PMP22_Claudin PF00822.20 ADV25789.1 - 0.014 15.2 3.7 0.014 15.2 3.7 3.0 2 1 1 3 3 3 0 PMP-22/EMP/MP20/Claudin family DUF2407 PF10302.9 ADV25790.1 - 4.8e-13 49.6 0.0 8.6e-13 48.8 0.0 1.4 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain DUF2407_C PF13373.6 ADV25790.1 - 8.6e-13 48.7 0.1 1.8e-12 47.6 0.1 1.5 1 0 0 1 1 1 1 DUF2407 C-terminal domain ubiquitin PF00240.23 ADV25790.1 - 0.001 18.8 0.0 0.0018 18.0 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family ALS_ss_C PF10369.9 ADV25791.1 - 8e-17 61.2 0.0 1.1e-15 57.5 0.0 2.3 2 0 0 2 2 2 1 Small subunit of acetolactate synthase ACT PF01842.25 ADV25791.1 - 3.7e-12 45.8 0.0 6.4e-12 45.0 0.0 1.4 1 0 0 1 1 1 1 ACT domain ACT_5 PF13710.6 ADV25791.1 - 9.2e-07 28.6 0.0 1.7e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 ACT domain DUF2187 PF09953.9 ADV25791.1 - 0.075 13.0 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2187) MEIOC PF15189.6 ADV25791.1 - 0.13 11.9 0.0 0.26 10.9 0.0 1.4 1 0 0 1 1 1 0 Meiosis-specific coiled-coil domain-containing protein MEIOC DUF4054 PF13262.6 ADV25792.1 - 0.072 13.1 0.1 0.1 12.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4054) DPPIV_N PF00930.21 ADV25793.1 - 4.9e-94 315.0 0.3 9.8e-94 314.0 0.3 1.5 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 ADV25793.1 - 2.1e-49 167.9 2.3 3.7e-49 167.1 2.3 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 ADV25793.1 - 0.0003 21.4 0.0 0.00093 19.9 0.0 1.9 1 0 0 1 1 1 1 Alpha/beta hydrolase family CSD2 PF17876.1 ADV25793.1 - 0.0039 17.3 0.1 0.0085 16.2 0.1 1.5 1 0 0 1 1 1 1 Cold shock domain Top6b_C PF18000.1 ADV25794.1 - 0.093 12.9 0.0 0.1 12.7 0.0 1.2 1 0 0 1 1 1 0 Type 2 DNA topoisomerase 6 subunit B C-terminal domain Efg1 PF10153.9 ADV25795.1 - 2.9e-24 85.6 6.8 2.9e-24 85.6 6.8 2.1 2 1 0 2 2 2 1 rRNA-processing protein Efg1 COX7C PF02935.16 ADV25796.1 - 2.1e-17 63.2 0.2 2.4e-17 62.9 0.2 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIIc TPR_2 PF07719.17 ADV25797.1 - 2.8e-13 48.9 1.0 2.4e-06 27.2 0.2 4.5 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 ADV25797.1 - 2.8e-12 45.9 2.1 1.6e-05 24.5 0.2 4.3 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 ADV25797.1 - 7.7e-11 41.5 1.7 0.0052 16.4 0.0 4.0 3 1 1 4 4 4 3 TPR repeat TPR_19 PF14559.6 ADV25797.1 - 1.4e-10 41.5 0.4 6.8e-05 23.3 0.1 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 ADV25797.1 - 1.9e-09 37.3 0.2 0.00022 21.4 0.0 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 ADV25797.1 - 2.1e-09 37.9 0.2 0.0021 18.6 0.1 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 ADV25797.1 - 4.3e-08 33.3 1.2 0.016 15.5 0.2 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 ADV25797.1 - 1.5e-07 31.7 0.3 0.52 11.3 0.0 4.2 1 1 3 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 ADV25797.1 - 1.7e-06 27.8 1.2 0.19 12.0 0.1 4.3 4 1 1 5 5 5 2 Tetratricopeptide repeat MIT PF04212.18 ADV25797.1 - 0.00025 21.0 0.9 0.64 10.1 0.4 3.2 3 1 0 3 3 3 2 MIT (microtubule interacting and transport) domain ANAPC3 PF12895.7 ADV25797.1 - 0.00034 20.8 0.1 0.34 11.2 0.0 2.5 2 0 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 ADV25797.1 - 0.0011 18.8 3.1 0.098 12.7 0.0 4.1 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 ADV25797.1 - 0.0021 18.5 0.3 4.8 8.0 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.6 ADV25797.1 - 0.0042 16.9 4.2 2.2 8.3 0.0 3.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_5 PF12688.7 ADV25797.1 - 0.017 15.3 0.0 0.038 14.2 0.0 1.6 1 0 0 1 1 1 0 Tetratrico peptide repeat DSS1_SEM1 PF05160.13 ADV25800.1 - 8.3e-17 61.0 3.6 1.4e-16 60.3 3.6 1.3 1 0 0 1 1 1 1 DSS1/SEM1 family DUF3306 PF11748.8 ADV25800.1 - 0.0056 17.5 0.4 0.0073 17.2 0.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3306) E1-E2_ATPase PF00122.20 ADV25801.1 - 2.9e-50 170.3 0.0 2.9e-50 170.3 0.0 2.7 4 0 0 4 4 4 1 E1-E2 ATPase Hydrolase PF00702.26 ADV25801.1 - 1.4e-15 58.2 3.5 1.4e-14 54.9 3.5 2.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 ADV25801.1 - 1.3e-12 47.2 0.0 3.3e-12 45.9 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 ADV25801.1 - 0.00031 20.6 0.2 0.0014 18.4 0.1 2.1 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase Ysc84 PF04366.12 ADV25802.1 - 1.2e-42 144.7 0.1 2.2e-42 143.8 0.1 1.5 1 0 0 1 1 1 1 Las17-binding protein actin regulator DUF1908 PF08926.11 ADV25803.1 - 0.45 9.6 0.9 0.55 9.3 0.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1908) HrcA_DNA-bdg PF03444.15 ADV25803.1 - 2.1 8.1 3.3 1.1 8.9 0.3 1.8 1 1 1 2 2 2 0 Winged helix-turn-helix transcription repressor, HrcA DNA-binding NOG1_N PF17835.1 ADV25804.1 - 4.6e-50 169.7 0.8 4.6e-50 169.7 0.8 2.6 2 1 1 3 3 3 1 NOG1 N-terminal helical domain NOG1 PF06858.14 ADV25804.1 - 3.2e-28 97.3 0.2 1.6e-27 95.0 0.1 2.2 2 0 0 2 2 2 1 Nucleolar GTP-binding protein 1 (NOG1) NOGCT PF08155.11 ADV25804.1 - 6.2e-26 90.1 1.3 6.2e-26 90.1 1.3 2.0 2 0 0 2 2 2 1 NOGCT (NUC087) domain MMR_HSR1 PF01926.23 ADV25804.1 - 8.6e-18 64.5 0.0 3.1e-17 62.7 0.0 2.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ADV25804.1 - 6.7e-09 35.5 0.1 1.5e-08 34.3 0.1 1.6 1 1 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 ADV25804.1 - 0.0019 18.2 2.0 3.1 7.8 0.0 3.4 2 1 1 3 3 3 2 Dynamin family RsgA_GTPase PF03193.16 ADV25804.1 - 0.0096 15.8 0.1 1.4 8.8 0.0 3.1 2 1 0 2 2 2 1 RsgA GTPase Roc PF08477.13 ADV25804.1 - 0.026 14.7 0.0 0.21 11.8 0.0 2.3 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AIG1 PF04548.16 ADV25804.1 - 0.069 12.5 0.0 0.17 11.2 0.0 1.7 1 0 0 1 1 1 0 AIG1 family AAA_16 PF13191.6 ADV25804.1 - 0.099 13.0 2.2 0.32 11.3 0.0 2.8 3 1 0 3 3 3 0 AAA ATPase domain YabA PF06156.13 ADV25804.1 - 9.1 7.0 8.5 7.5 7.2 1.3 2.9 2 0 0 2 2 2 0 Initiation control protein YabA DUF5526 PF17664.1 ADV25805.1 - 0.097 12.2 1.4 0.22 11.1 0.1 1.9 1 1 1 2 2 2 0 Family of unknown function (DUF5526) RRM_1 PF00076.22 ADV25806.1 - 7.8e-58 192.2 0.0 1.5e-15 56.7 0.0 6.9 7 0 0 7 7 7 6 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ADV25806.1 - 0.00017 21.6 0.0 26 5.0 0.0 4.4 4 0 0 4 4 4 2 RNA recognition motif RRM_Rrp7 PF17799.1 ADV25806.1 - 0.059 13.2 0.1 7.4 6.3 0.0 3.5 3 0 0 3 3 3 0 Rrp7 RRM-like N-terminal domain RAP1 PF07218.11 ADV25806.1 - 0.11 10.7 6.9 0.18 10.1 6.9 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Nup35_RRM_2 PF14605.6 ADV25806.1 - 0.17 11.9 0.0 30 4.7 0.0 2.6 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif Smg8_Smg9 PF10220.9 ADV25806.1 - 6.9 4.8 5.8 12 4.1 5.8 1.3 1 0 0 1 1 1 0 Smg8_Smg9 RRM_1 PF00076.22 ADV25807.1 - 3.2e-31 106.9 0.0 2.2e-15 56.2 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ADV25807.1 - 1.2e-11 44.6 0.0 0.00029 20.9 0.0 2.7 2 2 0 2 2 2 2 RNA recognition motif CUE PF02845.16 ADV25808.1 - 3.2e-08 33.1 0.0 4.8e-08 32.5 0.0 1.3 1 0 0 1 1 1 1 CUE domain DDE_1 PF03184.19 ADV25810.1 - 0.015 15.0 0.0 0.016 14.9 0.0 1.1 1 0 0 1 1 1 0 DDE superfamily endonuclease Zn_clus PF00172.18 ADV25811.1 - 0.0069 16.5 15.1 0.013 15.6 15.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4567 PF15131.6 ADV25811.1 - 0.034 14.2 0.3 7.5 6.7 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4567) Shal-type PF11601.8 ADV25811.1 - 0.058 12.9 0.1 0.15 11.6 0.1 1.7 1 0 0 1 1 1 0 Shal-type voltage-gated potassium channels, N-terminal Sugar_tr PF00083.24 ADV25812.1 - 4e-81 273.2 16.0 1.9e-49 168.8 5.1 2.0 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 ADV25812.1 - 4.2e-30 104.9 18.8 1.3e-23 83.6 10.8 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 ADV25812.1 - 0.00021 20.0 2.3 0.00021 20.0 2.3 2.9 2 2 3 5 5 5 1 MFS/sugar transport protein Pex14_N PF04695.13 ADV25812.1 - 0.2 12.3 0.0 0.42 11.3 0.0 1.5 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Chitin_synth_1 PF01644.17 ADV25813.1 - 3.3e-75 251.5 0.0 5e-75 251.0 0.0 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_2 PF03142.15 ADV25813.1 - 2.1e-22 79.4 3.3 8.6e-20 70.8 0.0 2.3 2 0 0 2 2 2 2 Chitin synthase Chitin_synth_1N PF08407.11 ADV25813.1 - 2.7e-17 62.5 0.0 5.1e-17 61.6 0.0 1.5 1 0 0 1 1 1 1 Chitin synthase N-terminal Glyco_trans_2_3 PF13632.6 ADV25813.1 - 3.2e-09 37.0 2.8 3.2e-09 37.0 2.8 2.6 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Pkinase PF00069.25 ADV25814.1 - 5e-69 232.6 0.0 6.4e-69 232.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ADV25814.1 - 7.8e-35 120.4 0.0 1e-34 120.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ADV25814.1 - 5.5e-11 42.3 0.0 9.8e-11 41.5 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 ADV25814.1 - 0.03 13.3 0.0 0.064 12.2 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 ADV25814.1 - 0.1 12.0 0.5 0.18 11.1 0.5 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pneumo_att_G PF05539.11 ADV25814.1 - 2.6 7.5 10.9 4.1 6.9 10.9 1.2 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G Ank_2 PF12796.7 ADV25816.1 - 1.8e-05 25.2 0.0 0.038 14.6 0.0 3.7 3 1 1 4 4 4 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ADV25816.1 - 4.9e-05 23.8 0.3 0.0012 19.4 0.0 3.0 3 2 0 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 ADV25816.1 - 0.0028 18.0 0.2 3 8.7 0.0 4.1 4 1 0 4 4 4 1 Ankyrin repeat Ank PF00023.30 ADV25816.1 - 0.16 12.5 0.0 2.9 8.5 0.0 2.9 3 0 0 3 3 3 0 Ankyrin repeat ATP_bind_1 PF03029.17 ADV25817.1 - 9.8e-74 248.2 0.0 1.5e-73 247.6 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein MeaB PF03308.16 ADV25817.1 - 0.0002 20.4 0.0 0.00035 19.6 0.0 1.3 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_30 PF13604.6 ADV25817.1 - 0.0054 16.5 0.0 0.012 15.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ADV25817.1 - 0.0059 17.1 0.2 0.024 15.2 0.0 2.3 3 1 0 3 3 3 1 AAA domain CLP1_P PF16575.5 ADV25817.1 - 0.015 15.1 0.0 0.028 14.2 0.0 1.5 1 1 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop NTPase_1 PF03266.15 ADV25817.1 - 0.03 14.3 0.0 0.084 12.8 0.0 1.7 1 0 0 1 1 1 0 NTPase KTI12 PF08433.10 ADV25817.1 - 0.033 13.6 0.0 0.061 12.8 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_33 PF13671.6 ADV25817.1 - 0.05 13.8 0.0 0.1 12.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 ADV25817.1 - 0.091 12.5 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.6 ADV25817.1 - 0.11 12.8 0.0 0.25 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ADV25817.1 - 0.12 12.7 0.0 0.2 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain MMR_HSR1 PF01926.23 ADV25817.1 - 0.13 12.3 0.0 7.8 6.6 0.0 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_17 PF13207.6 ADV25817.1 - 0.17 12.3 0.2 0.48 10.9 0.2 1.7 1 0 0 1 1 1 0 AAA domain Toxin_21 PF08091.11 ADV25819.1 - 3.4 7.7 6.7 19 5.3 1.1 3.4 3 0 0 3 3 3 0 Spider insecticidal peptide LRR_4 PF12799.7 ADV25820.1 - 2.5e-07 30.9 13.1 0.031 14.7 0.6 6.5 4 3 4 8 8 8 4 Leucine Rich repeats (2 copies) F-box-like PF12937.7 ADV25820.1 - 0.00052 19.9 0.1 0.0099 15.7 0.0 2.6 2 0 0 2 2 2 1 F-box-like LRR_6 PF13516.6 ADV25820.1 - 0.055 13.5 10.9 19 5.7 0.4 6.2 7 0 0 7 7 7 0 Leucine Rich repeat LRR_1 PF00560.33 ADV25820.1 - 0.068 13.7 13.7 25 5.9 0.1 6.5 6 1 0 6 6 6 0 Leucine Rich Repeat IPK PF03770.16 ADV25821.1 - 1.7e-42 145.6 0.0 1.7e-23 83.6 0.0 2.2 2 0 0 2 2 2 2 Inositol polyphosphate kinase Astro_capsid_p PF12226.8 ADV25821.1 - 1.1 8.3 6.5 1.6 7.8 6.5 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein CENP-B_dimeris PF09026.10 ADV25821.1 - 1.8 9.0 11.0 3.3 8.2 11.0 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain PBP1_TM PF14812.6 ADV25821.1 - 2.2 8.7 9.5 5.4 7.5 9.5 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CDC45 PF02724.14 ADV25821.1 - 2.6 6.2 5.2 4.2 5.5 5.2 1.2 1 0 0 1 1 1 0 CDC45-like protein Mito_carr PF00153.27 ADV25822.1 - 2.5e-56 187.6 0.9 3.5e-19 68.5 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Myco_arth_vir_N PF09610.10 ADV25822.1 - 2.7 8.1 5.0 0.46 10.6 0.4 2.1 2 0 0 2 2 2 0 Mycoplasma virulence signal region (Myco_arth_vir_N) O-FucT PF10250.9 ADV25824.1 - 3e-12 46.9 0.0 3.8e-12 46.6 0.0 1.1 1 0 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase Glucan_synthase PF02364.15 ADV25825.1 - 0 1321.3 0.0 0 1320.5 0.0 1.4 2 0 0 2 2 2 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.6 ADV25825.1 - 4e-43 146.8 0.1 1.1e-42 145.4 0.1 1.8 1 0 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 adh_short PF00106.25 ADV25826.1 - 4.4e-30 104.6 2.4 5.7e-29 101.0 2.4 2.0 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ADV25826.1 - 9.2e-30 103.9 0.2 2e-15 57.0 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ADV25826.1 - 2.7e-08 33.9 0.8 3.3e-08 33.7 0.2 1.4 2 0 0 2 2 2 1 KR domain F420_oxidored PF03807.17 ADV25826.1 - 0.0059 17.2 0.7 0.015 15.8 0.6 1.8 1 1 1 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.18 ADV25826.1 - 0.044 13.7 0.5 0.068 13.0 0.5 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pirin PF02678.16 ADV25827.1 - 7e-27 93.5 0.3 7e-27 93.5 0.3 1.6 2 0 0 2 2 2 1 Pirin Cupin_2 PF07883.11 ADV25827.1 - 4.5e-08 32.7 1.0 8e-06 25.5 0.1 2.3 2 0 0 2 2 2 2 Cupin domain GGA_N-GAT PF18308.1 ADV25828.1 - 0.023 14.3 0.2 0.03 13.9 0.2 1.2 1 0 0 1 1 1 0 GGA N-GAT domain C2 PF00168.30 ADV25829.1 - 6.1e-10 39.3 0.0 1.9e-09 37.7 0.0 1.8 2 0 0 2 2 2 1 C2 domain Membr_traf_MHD PF10540.9 ADV25829.1 - 2.2e-08 34.4 0.0 0.0013 18.9 0.1 2.7 1 1 1 2 2 2 2 Munc13 (mammalian uncoordinated) homology domain Coq4 PF05019.13 ADV25829.1 - 0.046 13.0 0.0 6.8 5.9 0.0 2.3 2 0 0 2 2 2 0 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 Methyltransf_25 PF13649.6 ADV25830.1 - 4.2e-11 43.4 0.0 6e-11 42.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ADV25830.1 - 4.3e-11 43.3 0.0 5.9e-11 42.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ADV25830.1 - 4.2e-09 36.4 0.0 5.3e-09 36.0 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ADV25830.1 - 1.5e-05 25.6 0.0 2e-05 25.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 ADV25830.1 - 0.0012 18.8 0.0 0.0015 18.6 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ADV25830.1 - 0.0024 17.4 0.0 0.0032 17.0 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase small domain TehB PF03848.14 ADV25830.1 - 0.066 12.6 0.0 0.082 12.3 0.0 1.1 1 0 0 1 1 1 0 Tellurite resistance protein TehB Pox_MCEL PF03291.16 ADV25830.1 - 0.13 11.4 0.0 0.17 11.0 0.0 1.1 1 0 0 1 1 1 0 mRNA capping enzyme Sugar_tr PF00083.24 ADV25831.1 - 5.4e-125 417.8 22.4 6.4e-125 417.5 22.4 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ADV25831.1 - 1.7e-22 79.8 34.3 4.3e-17 62.1 14.9 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Brr6_like_C_C PF10104.9 ADV25831.1 - 0.15 11.9 2.1 0.43 10.3 2.1 1.7 1 0 0 1 1 1 0 Di-sulfide bridge nucleocytoplasmic transport domain APG5 PF04106.12 ADV25833.1 - 4.6e-49 167.1 0.0 5.7e-49 166.8 0.0 1.1 1 0 0 1 1 1 1 Autophagy protein Apg5 CT_A_B PF02626.15 ADV25835.1 - 6.2e-77 258.8 0.1 9.7e-77 258.1 0.1 1.3 1 0 0 1 1 1 1 Carboxyltransferase domain, subdomain A and B CPSase_L_D2 PF02786.17 ADV25835.1 - 2e-57 194.1 0.0 3.9e-57 193.2 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 ADV25835.1 - 5.1e-36 123.6 0.1 1.6e-35 122.0 0.0 1.9 2 0 0 2 2 2 1 Biotin carboxylase, N-terminal domain CT_C_D PF02682.16 ADV25835.1 - 8.3e-35 120.4 0.0 1.4e-34 119.6 0.0 1.4 1 0 0 1 1 1 1 Carboxyltransferase domain, subdomain C and D Biotin_carb_C PF02785.19 ADV25835.1 - 4.1e-28 97.6 0.0 1e-27 96.4 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Dala_Dala_lig_C PF07478.13 ADV25835.1 - 2e-11 43.8 0.0 4.1e-11 42.8 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus Biotin_lipoyl PF00364.22 ADV25835.1 - 0.00022 21.0 0.0 0.00085 19.1 0.0 2.0 1 0 0 1 1 1 1 Biotin-requiring enzyme ATP-grasp PF02222.22 ADV25835.1 - 0.0017 18.0 0.0 0.0032 17.1 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain Glyco_hydro_4C PF11975.8 ADV25835.1 - 0.022 14.8 0.0 0.044 13.9 0.0 1.4 1 0 0 1 1 1 0 Family 4 glycosyl hydrolase C-terminal domain RimK PF08443.11 ADV25835.1 - 0.034 13.8 0.0 0.13 11.8 0.0 2.0 1 1 0 1 1 1 0 RimK-like ATP-grasp domain ATP-grasp_5 PF13549.6 ADV25835.1 - 0.066 12.6 0.0 0.15 11.5 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain Cullin PF00888.22 ADV25837.1 - 1.7e-16 60.0 0.0 2.8e-16 59.3 0.0 1.2 1 0 0 1 1 1 1 Cullin family HCNGP PF07818.13 ADV25839.1 - 5.8e-23 81.4 0.0 1e-22 80.6 0.0 1.4 1 0 0 1 1 1 1 HCNGP-like protein Transp_cyt_pur PF02133.15 ADV25840.1 - 4.4e-92 309.1 38.4 5.3e-92 308.9 38.4 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Glyco_hydro_72 PF03198.14 ADV25841.1 - 2.6e-99 332.4 0.2 3.5e-99 332.0 0.2 1.1 1 0 0 1 1 1 1 Glucanosyltransferase X8 PF07983.13 ADV25841.1 - 1.7e-20 73.4 1.1 3.5e-20 72.5 1.1 1.5 1 0 0 1 1 1 1 X8 domain Cellulase PF00150.18 ADV25841.1 - 2.8e-05 23.7 0.1 0.00012 21.6 0.1 1.9 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_2_C PF02836.17 ADV25841.1 - 0.012 14.8 0.0 0.037 13.1 0.1 1.7 2 1 0 2 2 2 0 Glycosyl hydrolases family 2, TIM barrel domain Podoplanin PF05808.11 ADV25841.1 - 3.8 7.6 7.1 0.27 11.3 1.9 1.7 2 0 0 2 2 2 0 Podoplanin PAP2 PF01569.21 ADV25842.1 - 2.4e-28 98.6 2.3 2.4e-28 98.6 2.3 2.1 2 0 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 ADV25842.1 - 0.0016 18.1 7.0 0.017 14.8 6.7 2.5 1 1 0 1 1 1 1 PAP2 superfamily YhhN PF07947.14 ADV25842.1 - 0.017 14.7 2.2 0.027 14.1 0.2 2.0 2 0 0 2 2 2 0 YhhN family DUF2781 PF10914.8 ADV25842.1 - 0.072 13.5 0.9 21 5.5 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2781) DUF4131 PF13567.6 ADV25842.1 - 0.11 12.2 4.4 0.73 9.5 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) PsbJ PF01788.17 ADV25842.1 - 6.3 6.7 7.0 0.45 10.4 1.2 2.3 2 0 0 2 2 2 0 PsbJ EHN PF06441.12 ADV25843.1 - 6e-28 97.4 0.2 6e-28 97.4 0.2 1.6 2 0 0 2 2 2 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 ADV25843.1 - 2e-06 27.7 0.1 3.1e-06 27.0 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Thioredox_DsbH PF03190.15 ADV25844.1 - 4.4e-69 231.6 0.2 7.5e-69 230.9 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF255 Thioredoxin_7 PF13899.6 ADV25844.1 - 7.3e-07 29.3 0.0 1.5e-06 28.3 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like Sigma70_r4 PF04545.16 ADV25844.1 - 0.073 12.6 0.0 0.15 11.6 0.0 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 PfkB PF00294.24 ADV25846.1 - 1.1e-62 212.1 0.3 1.3e-62 211.8 0.3 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 ADV25846.1 - 0.012 15.0 0.0 0.027 13.9 0.0 1.5 1 1 0 1 1 1 0 Phosphomethylpyrimidine kinase SARAF PF06682.12 ADV25847.1 - 3.7e-64 217.5 1.1 5.8e-64 216.8 1.1 1.2 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis Arb1 PF09692.10 ADV25848.1 - 0.085 12.0 0.0 0.71 9.0 0.0 2.1 2 0 0 2 2 2 0 Argonaute siRNA chaperone (ARC) complex subunit Arb1 PhyH PF05721.13 ADV25849.1 - 3.6e-06 27.4 0.1 6.8e-06 26.5 0.1 1.4 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DUF1479 PF07350.12 ADV25849.1 - 8e-05 21.6 0.0 0.095 11.4 0.0 2.7 3 0 0 3 3 3 2 Protein of unknown function (DUF1479) 2OG-FeII_Oxy_3 PF13640.6 ADV25849.1 - 0.07 14.0 0.0 0.13 13.1 0.0 1.4 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_5 PF13759.6 ADV25849.1 - 0.095 13.1 0.0 0.18 12.2 0.0 1.4 1 0 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase Amidase PF01425.21 ADV25850.1 - 2.6e-98 329.9 0.0 4e-98 329.3 0.0 1.3 1 0 0 1 1 1 1 Amidase SHE3 PF17078.5 ADV25851.1 - 0.032 14.0 2.0 0.051 13.3 2.0 1.3 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 VHS PF00790.19 ADV25852.1 - 0.017 15.0 0.0 0.034 14.0 0.0 1.5 1 0 0 1 1 1 0 VHS domain GAT PF03127.14 ADV25852.1 - 0.054 13.8 0.0 6.2 7.2 0.0 2.5 2 0 0 2 2 2 0 GAT domain Ribosom_S12_S23 PF00164.25 ADV25853.1 - 3e-34 117.0 1.5 4.1e-34 116.6 1.5 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Herpes_UL35 PF04496.12 ADV25853.1 - 0.013 15.8 0.2 0.026 14.8 0.2 1.5 1 0 0 1 1 1 0 Herpesvirus UL35 family ILVD_EDD PF00920.21 ADV25853.1 - 0.016 13.8 0.1 0.018 13.7 0.1 1.0 1 0 0 1 1 1 0 Dehydratase family Ribosomal_S12 PF17487.2 ADV25853.1 - 0.067 13.9 0.0 0.18 12.6 0.0 1.6 1 1 0 1 1 1 0 Ribosomal protein S12 PhoLip_ATPase_C PF16212.5 ADV25854.1 - 1.1e-73 248.1 28.4 2.5e-73 246.9 28.4 1.6 1 0 0 1 1 1 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 ADV25854.1 - 2.8e-22 78.2 2.7 6.9e-22 76.9 2.7 1.8 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 ADV25854.1 - 6.6e-12 46.2 0.1 6.9e-05 23.2 0.0 3.4 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ADV25854.1 - 4e-10 39.7 0.0 1.3e-09 38.0 0.0 1.8 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 ADV25854.1 - 0.00015 21.6 0.3 0.0055 16.5 0.1 2.8 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 ADV25854.1 - 0.00021 20.8 0.0 0.0011 18.5 0.0 2.2 1 1 0 1 1 1 1 E1-E2 ATPase Inv-AAD PF18785.1 ADV25855.1 - 7.3e-21 74.4 0.0 1.2e-20 73.6 0.0 1.3 1 0 0 1 1 1 1 Invertebrate-AID/APOBEC-deaminase dCMP_cyt_deam_1 PF00383.23 ADV25855.1 - 4.4e-06 26.5 0.0 4.3e-05 23.3 0.0 2.1 2 0 0 2 2 2 1 Cytidine and deoxycytidylate deaminase zinc-binding region Cupin_8 PF13621.6 ADV25856.1 - 9.9e-28 97.5 0.1 1.6e-27 96.9 0.1 1.3 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 ADV25856.1 - 0.0065 16.0 0.0 0.011 15.2 0.0 1.3 1 0 0 1 1 1 1 Cupin superfamily protein Cupin_2 PF07883.11 ADV25856.1 - 0.014 15.1 0.0 0.029 14.1 0.0 1.5 1 0 0 1 1 1 0 Cupin domain Cupin_1 PF00190.22 ADV25856.1 - 0.019 14.6 0.0 0.047 13.3 0.0 1.5 1 1 0 1 1 1 0 Cupin JmjC PF02373.22 ADV25856.1 - 0.17 12.3 0.1 7.4 7.0 0.0 2.4 1 1 0 2 2 2 0 JmjC domain, hydroxylase RVT_1 PF00078.27 ADV25857.1 - 2.5e-11 43.5 0.0 1e-10 41.5 0.0 2.0 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) QIL1 PF15884.5 ADV25857.1 - 0.0058 17.2 0.0 8.2 7.1 0.0 2.7 2 0 0 2 2 2 2 MICOS complex subunit MIC13, QIL1 DUF2408 PF10303.9 ADV25857.1 - 0.03 14.9 0.2 12 6.4 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2408) NDUF_C2 PF06374.11 ADV25857.1 - 0.031 14.4 0.0 11 6.2 0.0 2.5 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2) UNC45-central PF11701.8 ADV25857.1 - 0.052 13.5 0.3 12 5.8 0.0 2.4 1 1 1 2 2 2 0 Myosin-binding striated muscle assembly central Vault_4 PF17796.1 ADV25857.1 - 0.16 12.1 0.0 28 4.9 0.0 2.6 2 0 0 2 2 2 0 Major Vault Protein repeat domain Adeno_100 PF02438.16 ADV25857.1 - 0.17 10.1 0.0 9.7 4.2 0.0 2.1 1 1 1 2 2 2 0 Late 100kD protein Kinesin PF00225.23 ADV25858.1 - 4.5e-98 328.2 0.0 6.9e-98 327.6 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ADV25858.1 - 3.3e-22 79.0 0.0 1.7e-21 76.7 0.0 2.2 2 0 0 2 2 2 1 Microtubule binding Filament PF00038.21 ADV25858.1 - 0.0041 16.8 14.3 0.14 11.8 14.3 2.6 1 1 0 1 1 1 1 Intermediate filament protein ATG16 PF08614.11 ADV25858.1 - 0.0091 16.2 19.0 1.3 9.2 13.2 3.6 2 1 1 3 3 3 3 Autophagy protein 16 (ATG16) Spc29 PF17082.5 ADV25858.1 - 1.4 8.7 10.9 1.1 9.1 6.0 2.5 1 1 1 2 2 2 0 Spindle Pole Component 29 Tup_N PF08581.10 ADV25858.1 - 2.4 8.5 13.1 4.7 7.6 0.1 4.7 5 1 0 5 5 5 0 Tup N-terminal SIKE PF05769.11 ADV25858.1 - 3.7 7.5 13.8 0.93 9.4 7.5 2.8 2 1 0 2 2 2 0 SIKE family DUF1192 PF06698.11 ADV25858.1 - 4.5 7.4 8.5 27 4.9 0.0 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF1192) DUF4704 PF15787.5 ADV25860.1 - 0.0053 16.0 1.5 0.019 14.2 0.2 2.7 3 0 0 3 3 3 1 Domain of unknown function (DUF4704) Laminin_G_3 PF13385.6 ADV25860.1 - 0.023 14.9 0.0 0.051 13.7 0.0 1.5 1 0 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily Beach PF02138.18 ADV25861.1 - 4.9e-109 364.0 0.0 7.4e-109 363.4 0.0 1.3 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 ADV25861.1 - 5.2e-11 42.5 0.0 1.2e-10 41.4 0.0 1.6 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH WD40 PF00400.32 ADV25861.1 - 0.0001 23.0 0.2 0.0014 19.4 0.0 3.1 3 0 0 3 3 3 1 WD domain, G-beta repeat FYVE PF01363.21 ADV25861.1 - 0.00035 20.7 6.7 0.00098 19.2 6.7 1.8 1 0 0 1 1 1 1 FYVE zinc finger zf-AN1 PF01428.16 ADV25861.1 - 0.48 10.6 5.0 0.12 12.5 1.3 1.9 1 1 1 2 2 2 0 AN1-like Zinc finger RasGEF PF00617.19 ADV25862.1 - 1.1e-50 172.2 0.1 3.4e-50 170.7 0.1 1.9 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ADV25862.1 - 4.1e-24 84.8 2.1 4.8e-24 84.6 0.4 2.1 2 0 0 2 2 2 1 RasGEF N-terminal motif SH3_1 PF00018.28 ADV25862.1 - 9.4e-15 54.0 0.0 2.2e-14 52.8 0.0 1.7 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 ADV25862.1 - 5.1e-13 48.5 0.0 1.1e-12 47.5 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 ADV25862.1 - 1.2e-11 44.2 0.0 3.4e-11 42.8 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain WW PF00397.26 ADV25862.1 - 7.8e-11 41.9 4.4 9e-07 28.9 0.7 2.5 2 0 0 2 2 2 2 WW domain DUF1729 PF08354.10 ADV25862.1 - 0.0023 16.9 0.2 0.038 12.9 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF1729) DUF4909 PF16253.5 ADV25862.1 - 0.051 13.4 0.0 0.097 12.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4909) FERM_M PF00373.18 ADV25862.1 - 0.14 12.6 0.0 1.3 9.4 0.0 2.7 3 1 0 3 3 3 0 FERM central domain DUF3752 PF12572.8 ADV25863.1 - 1.5e-33 116.5 8.7 1.5e-33 116.5 8.7 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF3752) LAP1C PF05609.12 ADV25863.1 - 0.6 9.1 5.3 0.83 8.7 5.3 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) CDC50 PF03381.15 ADV25864.1 - 9e-88 294.4 0.0 1.3e-87 293.9 0.0 1.2 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Cryptococcus_gattii_WM276-ASM18594v1/GCA_000185945.1_ASM18594v1_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Cryptococcus_gattii_WM276-ASM18594v1/GCA_000185945.1_ASM18594v1_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Cryptococcus_gattii_WM276-ASM18594v1/GCA_000185945.1_ASM18594v1_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Cryptococcus_gattii_WM276-ASM18594v1/GCA_000185945.1_ASM18594v1_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Sun Mar 24 18:14:05 2019 # [ok]