# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- BBE PF08031.12 CCF31720.1 - 4.2e-07 30.0 0.2 1.5e-06 28.2 0.2 2.0 2 0 0 2 2 2 1 Berberine and berberine like CDP-OH_P_transf PF01066.21 CCF31721.1 - 1.1e-16 61.3 2.1 1.4e-16 61.0 0.3 1.9 2 0 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Amidohydro_1 PF01979.20 CCF31723.1 - 4.9e-07 29.4 0.1 5.8e-07 29.1 0.1 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 CCF31723.1 - 5.4e-05 22.9 0.1 9.5e-05 22.0 0.1 1.4 1 1 0 1 1 1 1 Amidohydrolase family YbaJ PF10757.9 CCF31723.1 - 0.13 12.8 0.0 0.24 12.0 0.0 1.3 1 0 0 1 1 1 0 Biofilm formation regulator YbaJ T2SSI PF02501.17 CCF31725.1 - 0.038 14.2 0.3 0.066 13.4 0.3 1.4 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein I LPMO_10 PF03067.15 CCF31728.1 - 1.9e-14 54.8 0.6 2.6e-14 54.3 0.6 1.2 1 0 0 1 1 1 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading N_BRCA1_IG PF16158.5 CCF31728.1 - 0.014 16.1 0.0 0.045 14.5 0.0 1.8 1 1 1 2 2 2 0 Ig-like domain from next to BRCA1 gene GIY-YIG PF01541.24 CCF31730.1 - 1.4e-11 44.5 0.0 3.1e-11 43.4 0.0 1.5 2 0 0 2 2 2 1 GIY-YIG catalytic domain zf-HC5HC2H PF13771.6 CCF31730.1 - 0.0054 17.0 2.8 0.009 16.2 2.8 1.3 1 0 0 1 1 1 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 CCF31730.1 - 0.015 15.5 2.6 0.025 14.8 2.6 1.3 1 0 0 1 1 1 0 PHD-zinc-finger like domain T5orf172 PF10544.9 CCF31730.1 - 0.094 13.3 0.0 0.18 12.4 0.0 1.4 1 0 0 1 1 1 0 T5orf172 domain zf-C2HC PF01530.18 CCF31730.1 - 0.14 12.4 1.5 0.34 11.1 1.5 1.7 1 0 0 1 1 1 0 Zinc finger, C2HC type FANCL_C PF11793.8 CCF31730.1 - 0.44 10.8 4.8 1.1 9.5 4.8 1.6 1 1 0 1 1 1 0 FANCL C-terminal domain PHD PF00628.29 CCF31730.1 - 0.86 9.5 7.5 1.3 9.0 7.5 1.3 1 0 0 1 1 1 0 PHD-finger zf-RING-like PF08746.11 CCF31730.1 - 2.8 8.3 7.1 12 6.3 7.1 2.0 1 1 0 1 1 1 0 RING-like domain Prok-RING_1 PF14446.6 CCF31730.1 - 6 6.9 7.7 0.51 10.3 2.6 1.8 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 MCM_lid PF17855.1 CCF31732.1 - 0.17 12.3 0.0 0.34 11.3 0.0 1.4 1 0 0 1 1 1 0 MCM AAA-lid domain Gpr1_Fun34_YaaH PF01184.19 CCF31733.1 - 4.7e-31 108.0 0.5 6.2e-31 107.6 0.5 1.1 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family SCO1-SenC PF02630.14 CCF31735.1 - 4.4e-43 146.4 0.1 6.2e-43 145.9 0.1 1.2 1 0 0 1 1 1 1 SCO1/SenC AhpC-TSA PF00578.21 CCF31735.1 - 4.8e-07 29.7 0.0 7.9e-07 29.0 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_8 PF13905.6 CCF31735.1 - 0.0063 16.8 0.0 0.011 16.0 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like Redoxin PF08534.10 CCF31735.1 - 0.026 14.2 0.0 0.039 13.7 0.0 1.2 1 0 0 1 1 1 0 Redoxin TFB6 PF17110.5 CCF31737.1 - 1.8e-69 232.8 0.0 2.3e-69 232.5 0.0 1.1 1 0 0 1 1 1 1 Subunit 11 of the general transcription factor TFIIH Cwf_Cwc_15 PF04889.12 CCF31737.1 - 2.7 7.7 8.6 3.8 7.2 8.6 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Glyco_hydro_16 PF00722.21 CCF31738.1 - 2.1e-14 53.4 0.0 8.9e-14 51.4 0.0 1.8 1 1 0 1 1 1 1 Glycosyl hydrolases family 16 SKN1 PF03935.15 CCF31738.1 - 2e-05 23.2 1.3 0.033 12.6 0.6 2.1 1 1 1 2 2 2 2 Beta-glucan synthesis-associated protein (SKN1) DUF2401 PF10287.9 CCF31738.1 - 0.0051 16.4 0.0 0.011 15.4 0.0 1.5 1 0 0 1 1 1 1 Putative TOS1-like glycosyl hydrolase (DUF2401) NAD_binding_10 PF13460.6 CCF31741.1 - 0.00017 21.5 0.0 0.00018 21.5 0.0 1.0 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 CCF31741.1 - 0.023 14.3 0.0 0.023 14.2 0.0 1.0 1 0 0 1 1 1 0 NmrA-like family adh_short PF00106.25 CCF31741.1 - 0.066 12.7 0.0 0.066 12.7 0.0 1.0 1 0 0 1 1 1 0 short chain dehydrogenase HSP20 PF00011.21 CCF31743.1 - 9.8e-17 61.0 0.0 2.5e-11 43.6 0.0 2.3 2 0 0 2 2 2 2 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 CCF31743.1 - 1.4e-05 24.6 0.0 0.038 13.5 0.0 2.3 2 0 0 2 2 2 2 HSP20-like domain found in ArsA LysM PF01476.20 CCF31744.1 - 2.6e-15 56.2 0.0 5.1e-08 32.9 0.0 2.3 2 0 0 2 2 2 2 LysM domain Glyco_hydro_71 PF03659.14 CCF31745.1 - 1.9e-49 168.5 0.1 4.5e-46 157.4 0.0 2.1 2 0 0 2 2 2 2 Glycosyl hydrolase family 71 Prok-E2_C PF14459.6 CCF31745.1 - 0.083 13.0 0.0 0.24 11.6 0.0 1.8 1 0 0 1 1 1 0 Prokaryotic E2 family C Sugar_tr PF00083.24 CCF31746.1 - 5e-16 58.6 0.1 5.9e-16 58.4 0.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter SDH_beta PF03315.15 CCF31747.1 - 4.3e-37 127.9 0.0 6.6e-37 127.3 0.0 1.2 1 0 0 1 1 1 1 Serine dehydratase beta chain YpzI PF14140.6 CCF31750.1 - 0.65 9.8 3.8 8.3 6.3 0.2 2.5 2 0 0 2 2 2 0 YpzI-like protein Ank_4 PF13637.6 CCF31751.1 - 1.4e-17 63.8 0.0 1.8e-08 34.8 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 CCF31751.1 - 6.6e-16 58.7 0.0 1.2e-15 57.9 0.0 1.4 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 CCF31751.1 - 1.7e-12 47.2 0.1 0.0021 18.5 0.0 3.2 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.6 CCF31751.1 - 6.6e-09 35.3 0.0 0.062 13.9 0.0 3.6 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 CCF31751.1 - 4.9e-08 33.1 0.1 0.016 15.5 0.0 3.2 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Glyoxalase_6 PF18029.1 CCF31751.1 - 0.048 14.4 6.8 2.2 9.1 0.1 3.0 1 1 2 3 3 3 0 Glyoxalase-like domain Gas_vesicle PF00741.18 CCF31751.1 - 0.058 13.6 1.0 14 5.9 0.0 2.5 3 0 0 3 3 3 0 Gas vesicle protein Reductase_C PF14759.6 CCF31751.1 - 0.093 13.3 0.1 3.3 8.3 0.0 2.3 1 1 1 2 2 2 0 Reductase C-terminal Glyco_transf_28 PF03033.20 CCF31752.1 - 2.2e-16 60.2 0.1 2.5e-15 56.7 0.1 2.4 1 1 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain UDPGT PF00201.18 CCF31752.1 - 0.0001 21.3 0.0 0.00019 20.4 0.0 1.4 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 CCF31752.1 - 0.016 15.2 0.0 0.039 13.9 0.0 1.5 1 0 0 1 1 1 0 Glycosyltransferase family 28 C-terminal domain ATG_C PF09333.11 CCF31752.1 - 0.084 13.2 0.0 3.6 8.0 0.0 2.9 3 0 0 3 3 3 0 Autophagy-related protein C terminal domain Kinetochor_Ybp2 PF08568.10 CCF31753.1 - 6.8e-93 312.3 0.0 8.8e-93 311.9 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family, YAP/Alf4/glomulin FANCI_S3 PF14677.6 CCF31753.1 - 0.16 11.6 0.0 0.45 10.2 0.0 1.7 1 1 0 1 1 1 0 FANCI solenoid 3 2OG-FeII_Oxy PF03171.20 CCF31757.1 - 1.7e-19 70.2 0.0 3.8e-19 69.0 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 CCF31757.1 - 2.6e-17 63.7 0.0 4.2e-17 63.0 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal DUF167 PF02594.16 CCF31758.1 - 5.1e-24 84.2 0.2 8.2e-24 83.5 0.2 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YggU family COG1872 Glyco_hydro_28 PF00295.17 CCF31759.1 - 2.2e-45 155.1 6.6 7.8e-44 150.0 1.6 2.1 1 1 1 2 2 2 2 Glycosyl hydrolases family 28 Beta_helix PF13229.6 CCF31759.1 - 0.0072 16.2 4.1 0.0072 16.2 4.1 2.3 1 1 0 2 2 2 1 Right handed beta helix region Vps36_ESCRT-II PF11605.8 CCF31761.1 - 0.022 14.9 0.0 0.077 13.2 0.0 1.9 1 1 1 2 2 2 0 Vacuolar protein sorting protein 36 Vps36 DUF4551 PF15087.6 CCF31761.1 - 0.23 10.2 6.7 0.33 9.7 6.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Spt20 PF12090.8 CCF31761.1 - 0.77 9.3 12.8 1.2 8.7 12.8 1.3 1 0 0 1 1 1 0 Spt20 family Pterin_4a PF01329.19 CCF31762.1 - 1.3e-14 54.1 0.1 1.9e-14 53.6 0.1 1.2 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase Complex1_LYR_2 PF13233.6 CCF31764.1 - 3.4e-18 66.2 0.0 4.7e-18 65.7 0.0 1.2 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.15 CCF31764.1 - 2.1e-10 40.5 0.3 3.9e-10 39.6 0.1 1.6 2 0 0 2 2 2 1 Complex 1 protein (LYR family) DMPK_coil PF08826.10 CCF31765.1 - 0.038 14.1 1.4 8.8 6.5 0.5 2.7 1 1 2 3 3 3 0 DMPK coiled coil domain like FAD_binding_3 PF01494.19 CCF31766.1 - 7e-21 74.8 0.0 1.4e-20 73.9 0.0 1.4 1 1 0 1 1 1 1 FAD binding domain ADC PF06314.11 CCF31766.1 - 1.1e-16 61.1 0.0 2e-16 60.3 0.0 1.4 1 0 0 1 1 1 1 Acetoacetate decarboxylase (ADC) NAD_binding_8 PF13450.6 CCF31766.1 - 8.9e-08 32.3 0.6 3.5e-07 30.4 0.6 2.1 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CCF31766.1 - 2.3e-07 30.4 0.3 2.9e-05 23.5 0.1 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCF31766.1 - 3.2e-05 23.7 4.1 9.2e-05 22.2 2.1 2.0 1 1 1 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CCF31766.1 - 0.0006 19.0 1.5 0.00077 18.7 0.6 1.6 2 0 0 2 2 2 1 FAD binding domain Pyr_redox PF00070.27 CCF31766.1 - 0.0083 16.7 0.3 0.026 15.1 0.3 1.9 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CCF31766.1 - 0.014 14.5 0.7 0.023 13.8 0.7 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A HI0933_like PF03486.14 CCF31766.1 - 0.028 13.1 0.1 0.044 12.5 0.1 1.2 1 0 0 1 1 1 0 HI0933-like protein AlaDh_PNT_C PF01262.21 CCF31766.1 - 0.035 13.4 0.0 0.07 12.4 0.0 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_oxidored PF12831.7 CCF31766.1 - 0.061 12.7 0.3 0.13 11.6 0.3 1.5 1 0 0 1 1 1 0 FAD dependent oxidoreductase 3HCDH_N PF02737.18 CCF31766.1 - 0.082 12.8 0.1 0.16 11.9 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_9 PF13454.6 CCF31766.1 - 0.097 12.7 1.3 0.5 10.3 1.3 2.1 1 1 0 1 1 1 0 FAD-NAD(P)-binding Cupin_2 PF07883.11 CCF31767.1 - 3.7e-07 29.7 0.0 5.8e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 Cupin domain Cupin_3 PF05899.12 CCF31767.1 - 0.0011 18.6 0.0 0.002 17.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF861) Cupin_1 PF00190.22 CCF31767.1 - 0.0034 17.0 0.0 0.0049 16.5 0.0 1.3 1 0 0 1 1 1 1 Cupin FYVE PF01363.21 CCF31769.1 - 1.6e-20 73.0 0.6 1.6e-20 73.0 0.6 2.8 3 0 0 3 3 3 1 FYVE zinc finger Rad50_zn_hook PF04423.14 CCF31769.1 - 0.016 15.0 0.5 0.016 15.0 0.5 1.9 2 0 0 2 2 2 0 Rad50 zinc hook motif FYVE_2 PF02318.16 CCF31769.1 - 0.083 13.1 4.4 0.079 13.2 1.4 2.2 2 0 0 2 2 2 0 FYVE-type zinc finger zf-piccolo PF05715.13 CCF31769.1 - 0.14 12.3 17.3 0.069 13.3 5.3 3.0 3 0 0 3 3 3 0 Piccolo Zn-finger DZR PF12773.7 CCF31769.1 - 2.5 8.2 7.6 36 4.5 0.1 2.9 2 0 0 2 2 2 0 Double zinc ribbon KR PF08659.10 CCF31771.1 - 5e-66 222.0 0.1 6.5e-66 221.7 0.1 1.1 1 0 0 1 1 1 1 KR domain adh_short PF00106.25 CCF31771.1 - 3.3e-16 59.3 0.0 5.5e-16 58.6 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF31771.1 - 3.7e-09 36.5 0.1 5.5e-09 35.9 0.1 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase ADH_zinc_N_2 PF13602.6 CCF31771.1 - 2.6e-05 25.3 0.0 0.00029 21.9 0.0 2.4 3 0 0 3 3 3 1 Zinc-binding dehydrogenase Polysacc_synt_2 PF02719.15 CCF31771.1 - 0.1 11.7 0.0 0.12 11.5 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Creatininase PF02633.14 CCF31771.1 - 0.17 11.3 0.0 1.1 8.7 0.0 2.1 1 1 0 1 1 1 0 Creatinine amidohydrolase BMFP PF04380.13 CCF31773.1 - 0.013 15.9 0.1 0.014 15.8 0.1 1.1 1 0 0 1 1 1 0 Membrane fusogenic activity CCDC154 PF15450.6 CCF31773.1 - 0.021 13.4 0.1 0.021 13.4 0.1 1.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 154 Topoisom_bac PF01131.20 CCF31773.1 - 0.039 13.0 0.0 0.043 12.8 0.0 1.1 1 0 0 1 1 1 0 DNA topoisomerase DUF2076 PF09849.9 CCF31777.1 - 0.0047 17.0 0.5 0.0047 17.0 0.5 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) Homeobox_KN PF05920.11 CCF31777.1 - 0.039 13.9 0.0 0.082 12.8 0.0 1.5 1 0 0 1 1 1 0 Homeobox KN domain HSF_DNA-bind PF00447.17 CCF31778.1 - 7.3e-06 26.5 0.0 1.2e-05 25.9 0.0 1.3 1 0 0 1 1 1 1 HSF-type DNA-binding p450 PF00067.22 CCF31780.1 - 1.6e-10 40.4 0.0 1.6e-10 40.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Guanylate_kin PF00625.21 CCF31781.1 - 2.9e-61 206.3 0.0 3.3e-61 206.1 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase AAA_33 PF13671.6 CCF31781.1 - 4.6e-06 26.9 0.0 6.5e-05 23.1 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CCF31781.1 - 6.3e-05 23.5 0.1 0.0002 21.9 0.1 1.8 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CCF31781.1 - 0.00018 21.9 0.1 0.00044 20.7 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 CCF31781.1 - 0.0021 18.3 0.0 0.0048 17.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain dNK PF01712.19 CCF31781.1 - 0.0062 16.4 0.0 2.3 8.0 0.0 2.2 2 0 0 2 2 2 2 Deoxynucleoside kinase MMR_HSR1 PF01926.23 CCF31781.1 - 0.018 15.1 0.0 0.081 13.0 0.0 2.2 1 1 0 1 1 1 0 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CCF31781.1 - 0.021 14.7 0.0 0.045 13.7 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_24 PF13479.6 CCF31781.1 - 0.029 14.1 0.0 2.5 7.8 0.0 2.1 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 CCF31781.1 - 0.035 14.0 0.1 1.8 8.5 0.0 2.1 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea ABC_tran PF00005.27 CCF31781.1 - 0.049 14.1 0.1 0.12 12.9 0.1 1.8 1 1 0 1 1 1 0 ABC transporter AAA_28 PF13521.6 CCF31781.1 - 0.063 13.5 0.1 0.46 10.7 0.2 2.2 1 1 0 1 1 1 0 AAA domain AAA_14 PF13173.6 CCF31781.1 - 0.083 12.9 0.0 0.65 10.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.15 CCF31781.1 - 0.14 12.1 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain DPBB_1 PF03330.18 CCF31782.1 - 3.1e-08 33.8 1.2 4.4e-07 30.1 0.2 2.8 2 1 0 2 2 2 1 Lytic transglycolase Barwin PF00967.17 CCF31782.1 - 8.2e-05 22.4 0.9 0.00044 20.1 0.1 2.1 2 0 0 2 2 2 1 Barwin family Pollen_allerg_1 PF01357.21 CCF31782.1 - 0.00026 21.0 3.4 0.00048 20.1 3.4 1.4 1 0 0 1 1 1 1 Pollen allergen BNR PF02012.20 CCF31782.1 - 0.011 15.6 0.1 0.032 14.2 0.1 1.9 1 0 0 1 1 1 0 BNR/Asp-box repeat CHB_HEX_C PF03174.13 CCF31782.1 - 0.081 12.9 0.2 0.26 11.3 0.2 1.9 1 1 0 1 1 1 0 Chitobiase/beta-hexosaminidase C-terminal domain Disintegrin PF00200.23 CCF31786.1 - 3e-17 63.2 32.3 3e-17 63.2 32.3 4.6 3 1 0 3 3 3 1 Disintegrin Reprolysin_2 PF13574.6 CCF31786.1 - 3.6e-14 53.1 2.5 3.6e-14 53.1 2.5 1.9 2 1 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 CCF31786.1 - 2.7e-12 47.3 5.5 2.7e-12 47.3 5.5 3.4 2 1 1 3 3 3 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.6 CCF31786.1 - 3.2e-11 43.3 1.2 6.8e-11 42.2 1.2 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like ADAM_CR_2 PF17771.1 CCF31786.1 - 0.00024 21.5 13.6 0.00024 21.5 13.6 5.5 2 1 3 5 5 5 1 ADAM cysteine-rich domain Synaptobrevin PF00957.21 CCF31786.1 - 1.8 8.4 3.7 3.1 7.7 3.7 1.3 1 0 0 1 1 1 0 Synaptobrevin FLILHELTA PF10306.9 CCF31787.1 - 7.5e-29 100.0 0.0 1.2e-28 99.4 0.0 1.3 1 0 0 1 1 1 1 Hypothetical protein FLILHELTA Pkinase PF00069.25 CCF31788.1 - 2.6e-14 53.2 0.0 6.4e-14 51.9 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF31788.1 - 1.3e-12 47.6 0.0 1.4e-11 44.2 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 CCF31788.1 - 2.4e-07 30.3 0.1 6.1e-07 29.0 0.0 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CCF31788.1 - 0.00026 21.0 0.1 0.00039 20.4 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 CCF31788.1 - 0.022 14.1 0.0 0.029 13.7 0.0 1.1 1 0 0 1 1 1 0 Kinase-like RIO1 PF01163.22 CCF31788.1 - 0.045 13.4 0.0 0.076 12.6 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Choline_kinase PF01633.20 CCF31788.1 - 0.066 12.8 0.0 0.094 12.3 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase AAA_17 PF13207.6 CCF31789.1 - 0.027 14.9 1.1 0.033 14.6 1.1 1.2 1 0 0 1 1 1 0 AAA domain T4SS_CagC PF16943.5 CCF31789.1 - 0.21 11.8 0.8 0.27 11.4 0.8 1.3 1 0 0 1 1 1 0 Cag pathogenicity island, type IV secretory system Trp_leader2 PF08056.11 CCF31789.1 - 3.9 7.5 6.5 34 4.5 0.1 3.9 4 1 1 5 5 5 0 Tryptophan operon leader peptide FMO-like PF00743.19 CCF31790.1 - 9.9e-12 44.0 0.1 3.2e-11 42.4 0.0 1.8 2 1 0 2 2 2 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 CCF31790.1 - 4.2e-09 36.0 0.0 7.9e-07 28.6 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCF31790.1 - 2.6e-08 34.0 0.0 1.9e-07 31.2 0.0 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 CCF31790.1 - 1.1e-06 28.1 0.0 3.3e-06 26.6 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CCF31790.1 - 2.9e-06 26.7 0.0 0.00029 20.2 0.0 2.2 2 0 0 2 2 2 1 Thi4 family DAO PF01266.24 CCF31790.1 - 6.3e-06 26.0 1.0 0.012 15.2 0.1 3.5 2 1 1 4 4 4 1 FAD dependent oxidoreductase Shikimate_DH PF01488.20 CCF31790.1 - 0.028 14.5 0.0 0.72 9.9 0.0 3.0 4 0 0 4 4 4 0 Shikimate / quinate 5-dehydrogenase GIDA PF01134.22 CCF31790.1 - 0.083 12.0 0.9 4.9 6.1 0.2 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A Amino_oxidase PF01593.24 CCF31790.1 - 0.089 12.1 0.0 0.19 10.9 0.0 1.7 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase FAD_oxidored PF12831.7 CCF31790.1 - 0.14 11.5 0.0 0.29 10.4 0.0 1.5 1 0 0 1 1 1 0 FAD dependent oxidoreductase FmdA_AmdA PF03069.15 CCF31791.1 - 4.9e-134 446.9 0.0 5.6e-134 446.7 0.0 1.0 1 0 0 1 1 1 1 Acetamidase/Formamidase family OTU PF02338.19 CCF31792.1 - 1.6e-09 38.3 0.0 2.7e-09 37.6 0.0 1.3 1 0 0 1 1 1 1 OTU-like cysteine protease Bromodomain PF00439.25 CCF31793.1 - 5.8e-44 148.1 1.3 2.4e-22 78.8 0.0 2.5 2 0 0 2 2 2 2 Bromodomain BAH PF01426.18 CCF31793.1 - 5.2e-17 61.8 0.3 1.4e-16 60.4 0.3 1.8 1 0 0 1 1 1 1 BAH domain Ribosomal_60s PF00428.19 CCF31793.1 - 0.0014 19.2 8.2 0.0014 19.2 8.2 4.0 4 1 0 4 4 4 1 60s Acidic ribosomal protein TetR_C_10 PF16295.5 CCF31793.1 - 0.11 12.7 0.0 5.1 7.4 0.0 2.7 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Peptidase_C37 PF05416.12 CCF31793.1 - 0.29 9.6 3.2 0.66 8.4 3.2 1.5 1 0 0 1 1 1 0 Southampton virus-type processing peptidase MORN PF02493.20 CCF31794.1 - 0.029 14.3 0.4 0.064 13.2 0.4 1.6 1 0 0 1 1 1 0 MORN repeat PAS_9 PF13426.7 CCF31796.1 - 2.7e-24 85.4 0.0 2.6e-16 59.8 0.0 3.5 3 0 0 3 3 3 3 PAS domain PAS_3 PF08447.12 CCF31796.1 - 4.3e-20 71.8 0.0 8.8e-12 45.2 0.0 4.1 4 0 0 4 4 4 3 PAS fold PAS PF00989.25 CCF31796.1 - 6.6e-16 58.3 0.0 9.2e-07 28.9 0.0 4.0 3 1 0 3 3 3 3 PAS fold GATA PF00320.27 CCF31796.1 - 2.3e-15 55.9 7.1 4.6e-15 54.9 7.1 1.6 1 0 0 1 1 1 1 GATA zinc finger PAS_4 PF08448.10 CCF31796.1 - 1.3e-09 38.3 0.0 0.0035 17.6 0.0 3.5 3 0 0 3 3 3 2 PAS fold PAS_11 PF14598.6 CCF31796.1 - 8.9e-07 29.0 0.0 0.0055 16.8 0.0 2.6 2 0 0 2 2 2 2 PAS domain PAS_2 PF08446.11 CCF31796.1 - 3.3e-05 24.5 0.0 0.088 13.5 0.0 3.5 3 0 0 3 3 3 1 PAS fold Alpha_Helical PF18489.1 CCF31797.1 - 0.1 12.8 0.0 0.19 11.9 0.0 1.4 1 0 0 1 1 1 0 Alpha helical domain CAS_CSE1 PF03378.15 CCF31798.1 - 4.1e-28 98.1 0.0 4.5e-28 97.9 0.0 1.0 1 0 0 1 1 1 1 CAS/CSE protein, C-terminus DUF3094 PF11293.8 CCF31798.1 - 0.085 12.6 0.4 0.18 11.5 0.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3094) DIT1_PvcA PF05141.12 CCF31799.1 - 2e-54 185.0 0.0 2.4e-54 184.7 0.0 1.0 1 0 0 1 1 1 1 Pyoverdine/dityrosine biosynthesis protein Tup_N PF08581.10 CCF31800.1 - 2e-12 47.3 9.6 5.6e-12 45.8 9.6 1.6 1 1 0 1 1 1 1 Tup N-terminal DUF2465 PF10239.9 CCF31800.1 - 0.00059 19.2 0.6 0.00071 18.9 0.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2465) USP8_interact PF08941.10 CCF31800.1 - 0.17 11.7 3.7 0.19 11.5 3.7 1.1 1 0 0 1 1 1 0 USP8 interacting TPX2 PF06886.11 CCF31800.1 - 0.25 11.6 3.1 1.6 9.0 3.1 2.1 1 1 0 1 1 1 0 Targeting protein for Xklp2 (TPX2) DUF5313 PF17240.2 CCF31801.1 - 0.18 12.2 3.5 0.22 11.9 3.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5313) Cas1_AcylT PF07779.12 CCF31802.1 - 1.7e-116 390.0 13.5 2.1e-116 389.6 13.5 1.1 1 0 0 1 1 1 1 10 TM Acyl Transferase domain found in Cas1p SfLAP PF11139.8 CCF31802.1 - 0.008 15.6 0.7 0.027 13.9 0.7 1.9 1 0 0 1 1 1 1 Sap, sulfolipid-1-addressing protein Nuc_deoxyri_tr2 PF15891.5 CCF31804.1 - 4.5e-37 126.7 0.0 5.9e-37 126.3 0.0 1.1 1 0 0 1 1 1 1 Nucleoside 2-deoxyribosyltransferase like SF3b1 PF08920.10 CCF31807.1 - 6.7e-29 100.8 7.6 6.7e-29 100.8 7.6 2.5 1 1 1 2 2 2 1 Splicing factor 3B subunit 1 UNC45-central PF11701.8 CCF31807.1 - 0.0021 18.0 0.0 0.0038 17.2 0.0 1.3 1 0 0 1 1 1 1 Myosin-binding striated muscle assembly central HEAT PF02985.22 CCF31807.1 - 0.0084 16.3 2.0 0.42 11.0 0.0 4.2 5 0 0 5 5 5 1 HEAT repeat Cnd1 PF12717.7 CCF31807.1 - 0.088 12.8 0.0 1.1 9.3 0.0 2.7 3 1 1 4 4 4 0 non-SMC mitotic condensation complex subunit 1 Hydin_ADK PF17213.3 CCF31807.1 - 0.13 12.5 4.8 0.29 11.4 4.8 1.5 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain OGG_N PF07934.12 CCF31808.1 - 1e-15 57.9 0.1 2.9e-15 56.4 0.1 1.7 1 1 0 1 1 1 1 8-oxoguanine DNA glycosylase, N-terminal domain HhH-GPD PF00730.25 CCF31808.1 - 2.6e-11 44.0 0.0 5.2e-11 42.9 0.0 1.5 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 CCF31808.1 - 0.0041 16.9 0.0 0.012 15.5 0.0 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix motif LSM PF01423.22 CCF31809.1 - 2e-17 62.6 0.5 2.5e-17 62.3 0.5 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 CCF31809.1 - 0.0027 17.8 0.0 0.0033 17.5 0.0 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain Hfq PF17209.3 CCF31809.1 - 0.01 15.5 0.0 0.014 15.0 0.0 1.3 1 0 0 1 1 1 0 Hfq protein DUF150_C PF17384.2 CCF31809.1 - 0.074 13.2 0.1 0.11 12.7 0.1 1.3 1 0 0 1 1 1 0 RimP C-terminal SH3 domain DRMBL PF07522.14 CCF31810.1 - 2.8e-34 117.6 0.1 5.1e-34 116.8 0.1 1.4 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.7 CCF31810.1 - 7.3e-07 28.9 0.0 1.4e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Isochorismatase PF00857.20 CCF31811.1 - 8.1e-28 97.8 0.1 9.1e-28 97.6 0.1 1.0 1 0 0 1 1 1 1 Isochorismatase family Glyco_hydro_115 PF15979.5 CCF31812.1 - 3.9e-34 118.6 0.0 4.4e-34 118.4 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 115 OrsD PF12013.8 CCF31814.1 - 0.0074 16.7 0.4 0.0082 16.6 0.4 1.2 1 0 0 1 1 1 1 Orsellinic acid/F9775 biosynthesis cluster protein D HSBP1 PF06825.12 CCF31816.1 - 4.9e-16 58.3 0.1 5.6e-16 58.1 0.1 1.1 1 0 0 1 1 1 1 Heat shock factor binding protein 1 Baculo_PEP_C PF04513.12 CCF31816.1 - 0.012 15.7 0.2 0.014 15.5 0.2 1.1 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DASH_Spc19 PF08287.11 CCF31816.1 - 0.032 14.1 0.0 0.04 13.8 0.0 1.1 1 0 0 1 1 1 0 Spc19 CheX PF13690.6 CCF31816.1 - 0.054 13.7 0.1 0.063 13.5 0.1 1.2 1 0 0 1 1 1 0 Chemotaxis phosphatase CheX DUF1664 PF07889.12 CCF31816.1 - 0.13 12.3 0.0 0.15 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Erythro-docking PF09277.11 CCF31816.1 - 0.47 10.4 2.2 2.9 7.9 0.3 2.4 1 1 2 3 3 3 0 Erythronolide synthase, docking Thioredoxin PF00085.20 CCF31817.1 - 1.3e-57 192.1 0.0 7.4e-30 103.0 0.0 2.3 2 0 0 2 2 2 2 Thioredoxin ERp29 PF07749.12 CCF31817.1 - 2.8e-26 92.2 2.2 3.8e-26 91.8 1.1 1.8 2 0 0 2 2 2 1 Endoplasmic reticulum protein ERp29, C-terminal domain Thioredoxin_2 PF13098.6 CCF31817.1 - 5.8e-16 58.9 0.0 1.6e-08 35.0 0.0 2.9 3 0 0 3 3 3 2 Thioredoxin-like domain OST3_OST6 PF04756.13 CCF31817.1 - 4.5e-13 49.2 0.0 3.2e-06 26.7 0.0 2.1 1 1 1 2 2 2 2 OST3 / OST6 family, transporter family Thioredoxin_7 PF13899.6 CCF31817.1 - 4.8e-08 33.1 0.0 0.0031 17.7 0.0 2.7 2 0 0 2 2 2 2 Thioredoxin-like Thioredoxin_8 PF13905.6 CCF31817.1 - 1.8e-07 31.4 0.0 0.0028 17.9 0.0 3.2 2 1 1 3 3 3 2 Thioredoxin-like AhpC-TSA PF00578.21 CCF31817.1 - 2.1e-07 30.9 0.0 0.0018 18.2 0.0 2.4 2 0 0 2 2 2 2 AhpC/TSA family Redoxin PF08534.10 CCF31817.1 - 6.9e-05 22.6 0.1 0.036 13.8 0.0 2.3 2 0 0 2 2 2 2 Redoxin TraF PF13728.6 CCF31817.1 - 0.0003 20.7 0.0 0.42 10.4 0.0 2.4 2 0 0 2 2 2 2 F plasmid transfer operon protein Thioredoxin_9 PF14595.6 CCF31817.1 - 0.00038 20.2 0.0 0.55 10.0 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin HyaE PF07449.11 CCF31817.1 - 0.00059 19.8 0.0 0.022 14.7 0.0 2.5 2 0 0 2 2 2 1 Hydrogenase-1 expression protein HyaE Glutaredoxin PF00462.24 CCF31817.1 - 0.023 14.9 0.2 9.6 6.5 0.0 2.8 2 1 0 2 2 2 0 Glutaredoxin Thioredoxin_3 PF13192.6 CCF31817.1 - 0.026 14.5 0.0 2.4 8.3 0.0 2.7 3 0 0 3 3 2 0 Thioredoxin domain Thioredoxin_4 PF13462.6 CCF31817.1 - 0.06 13.5 2.4 6.3 6.9 0.0 3.7 3 2 1 4 4 4 0 Thioredoxin Ribosomal_S14 PF00253.21 CCF31818.1 - 1.5e-14 53.4 3.4 1.7e-14 53.3 3.4 1.0 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e ZZ PF00569.17 CCF31818.1 - 0.18 11.6 4.3 2 8.3 4.3 2.1 1 1 0 1 1 1 0 Zinc finger, ZZ type GTP_EFTU PF00009.27 CCF31820.1 - 6.3e-57 192.3 0.2 8.6e-57 191.8 0.2 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 CCF31820.1 - 4.3e-26 91.4 0.0 9.4e-26 90.3 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 CCF31820.1 - 1.5e-15 57.3 3.0 1.5e-15 57.3 3.0 2.0 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CCF31820.1 - 1.4e-05 25.2 0.1 2.8e-05 24.2 0.1 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CCF31820.1 - 0.0009 19.2 0.0 0.0029 17.5 0.0 1.9 2 0 0 2 2 2 1 RsgA GTPase cobW PF02492.19 CCF31820.1 - 0.02 14.5 0.3 0.14 11.7 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain PduV-EutP PF10662.9 CCF31820.1 - 0.084 12.6 0.2 15 5.3 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Gtr1_RagA PF04670.12 CCF31820.1 - 0.19 11.0 0.1 0.72 9.2 0.1 1.8 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region DUF2011 PF09428.10 CCF31821.1 - 1.8e-21 76.2 0.2 6.5e-21 74.4 0.0 1.9 2 0 0 2 2 2 1 Fungal protein of unknown function (DUF2011) SPT16 PF08644.11 CCF31821.1 - 3.8 7.7 8.2 8.1 6.6 8.2 1.5 1 0 0 1 1 1 0 FACT complex subunit (SPT16/CDC68) FMO-like PF00743.19 CCF31822.1 - 7e-05 21.4 0.0 8e-05 21.3 0.0 1.1 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Type2_restr_D3 PF16902.5 CCF31822.1 - 0.17 11.8 0.0 0.31 11.0 0.0 1.3 1 0 0 1 1 1 0 Type-2 restriction enzyme D3 domain DUF918 PF06033.11 CCF31823.1 - 0.034 14.2 0.1 0.037 14.0 0.1 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF918) CDH-cyt PF16010.5 CCF31824.1 - 1.4e-56 191.1 1.3 1.4e-56 191.1 1.3 2.3 3 0 0 3 3 3 1 Cytochrome domain of cellobiose dehydrogenase GMC_oxred_N PF00732.19 CCF31824.1 - 9.4e-33 113.8 0.0 1.9e-32 112.8 0.0 1.6 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCF31824.1 - 9.2e-21 74.9 0.8 4.5e-20 72.6 0.8 2.0 2 0 0 2 2 2 1 GMC oxidoreductase DAO PF01266.24 CCF31824.1 - 2.3e-05 24.2 3.2 8.4e-05 22.3 3.2 1.8 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CCF31824.1 - 7.9e-05 21.9 7.5 0.00097 18.3 7.5 2.3 1 1 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 CCF31824.1 - 0.00022 20.1 2.1 0.0003 19.6 0.9 1.8 2 0 0 2 2 2 1 HI0933-like protein NAD_binding_8 PF13450.6 CCF31824.1 - 0.00057 20.1 0.2 0.00057 20.1 0.2 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 CCF31824.1 - 0.00099 18.6 1.6 0.002 17.6 0.7 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 CCF31824.1 - 0.0017 17.5 0.1 0.0032 16.6 0.1 1.5 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 CCF31824.1 - 0.0048 16.2 1.6 0.0082 15.4 0.1 2.1 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 CCF31824.1 - 0.006 15.9 0.0 0.01 15.1 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain Serglycin PF04360.12 CCF31824.1 - 0.031 14.2 1.6 0.063 13.2 1.6 1.5 1 0 0 1 1 1 0 Serglycin Pyr_redox PF00070.27 CCF31824.1 - 0.039 14.5 1.3 0.16 12.5 0.4 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 CCF31824.1 - 0.061 13.0 0.1 0.13 11.9 0.1 1.6 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Thi4 PF01946.17 CCF31824.1 - 0.095 11.9 1.1 0.24 10.6 0.8 1.7 2 0 0 2 2 2 0 Thi4 family PS-DH PF14765.6 CCF31825.1 - 1.1e-16 61.0 0.2 2.5e-15 56.5 0.1 2.3 2 0 0 2 2 2 1 Polyketide synthase dehydratase Methyltransf_12 PF08242.12 CCF31825.1 - 2.1e-16 60.5 0.0 7.9e-16 58.6 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF31825.1 - 2e-10 41.2 0.0 4e-09 37.1 0.0 2.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF31825.1 - 4.3e-08 33.7 0.0 2.3e-07 31.4 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF31825.1 - 1.9e-06 27.8 0.0 3.5e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Acyl_transf_1 PF00698.21 CCF31825.1 - 3.3e-05 23.6 0.0 0.00021 20.9 0.0 2.0 1 1 0 1 1 1 1 Acyl transferase domain Methyltransf_16 PF10294.9 CCF31825.1 - 0.002 17.9 0.0 0.0077 16.0 0.0 1.8 2 0 0 2 2 2 1 Lysine methyltransferase Methyltransf_31 PF13847.6 CCF31825.1 - 0.14 12.0 0.0 0.29 10.9 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Spc24 PF08286.11 CCF31826.1 - 5.7e-05 23.3 8.6 0.001 19.3 0.3 2.3 2 1 0 2 2 2 2 Spc24 subunit of Ndc80 Abi_C PF14355.6 CCF31826.1 - 0.0032 17.5 2.8 0.064 13.4 3.4 2.2 1 1 1 2 2 2 1 Abortive infection C-terminus Mod_r PF07200.13 CCF31826.1 - 0.0054 16.8 6.8 0.0064 16.6 6.8 1.0 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein GTA_holin_3TM PF11351.8 CCF31826.1 - 0.027 15.0 1.3 0.027 15.0 1.3 2.0 1 1 1 2 2 2 0 Holin of 3TMs, for gene-transfer release DUF1690 PF07956.11 CCF31826.1 - 0.039 14.4 5.7 0.052 14.0 5.7 1.1 1 0 0 1 1 1 0 Protein of Unknown function (DUF1690) HisKA_2 PF07568.12 CCF31826.1 - 0.04 14.0 1.2 0.064 13.4 1.2 1.5 1 0 0 1 1 1 0 Histidine kinase V_ATPase_I PF01496.19 CCF31826.1 - 0.064 11.2 4.4 0.064 11.2 4.4 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CLZ PF16526.5 CCF31826.1 - 0.55 10.6 7.4 1.5 9.3 2.8 2.8 2 1 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels ANAPC5 PF12862.7 CCF31826.1 - 1.8 8.7 7.3 4.4 7.4 5.7 2.0 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 5 XhlA PF10779.9 CCF31826.1 - 1.9 8.8 4.7 0.87 9.8 1.5 1.9 2 0 0 2 2 2 0 Haemolysin XhlA eIF3g PF12353.8 CCF31829.1 - 6.9e-24 84.6 0.9 8.5e-24 84.3 0.9 1.1 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G MFS_1 PF07690.16 CCF31830.1 - 2.4e-10 39.9 1.0 4.4e-10 39.0 1.0 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily NicO PF03824.16 CCF31830.1 - 0.0077 15.6 3.3 0.027 13.8 2.1 2.0 1 1 1 2 2 2 2 High-affinity nickel-transport protein Sugar_tr PF00083.24 CCF31830.1 - 0.02 13.8 0.2 0.028 13.3 0.2 1.2 1 0 0 1 1 1 0 Sugar (and other) transporter FAM101 PF15068.6 CCF31830.1 - 0.14 12.1 0.0 0.21 11.5 0.0 1.2 1 0 0 1 1 1 0 FAM101 family Lipase_GDSL_2 PF13472.6 CCF31832.1 - 2.6e-08 34.5 0.1 5.4e-08 33.4 0.1 1.6 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 CCF31832.1 - 0.002 18.1 0.0 0.004 17.1 0.0 1.4 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase SCAB-Ig PF16709.5 CCF31833.1 - 0.042 13.9 0.1 0.086 12.9 0.1 1.5 1 0 0 1 1 1 0 Ig domain of plant-specific actin-binding protein RasGEF PF00617.19 CCF31834.1 - 7e-60 202.2 0.1 1.3e-59 201.3 0.1 1.5 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 CCF31834.1 - 3.8e-29 101.0 0.8 8.2e-29 99.9 0.8 1.6 1 0 0 1 1 1 1 RasGEF N-terminal motif DUF3425 PF11905.8 CCF31835.1 - 2.2e-17 63.2 0.6 3.2e-17 62.6 0.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) Anophelin PF10731.9 CCF31836.1 - 3.1 7.7 5.8 2.1 8.2 3.0 1.9 1 1 1 2 2 2 0 Thrombin inhibitor from mosquito DUF4336 PF14234.6 CCF31837.1 - 2.2e-14 53.4 0.2 1.4e-08 34.3 0.0 2.6 2 1 0 2 2 2 2 Domain of unknown function (DUF4336) BTB PF00651.31 CCF31838.1 - 1.4e-11 44.6 0.0 2.7e-11 43.7 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain CNH PF00780.22 CCF31839.1 - 1.4e-80 270.9 0.0 4.8e-80 269.1 0.0 1.8 2 0 0 2 2 2 1 CNH domain PH_5 PF15405.6 CCF31839.1 - 4.7e-45 153.0 0.0 1e-44 151.9 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain RhoGEF PF00621.20 CCF31839.1 - 7.3e-36 124.1 0.0 1.4e-35 123.2 0.0 1.5 1 0 0 1 1 1 1 RhoGEF domain DEP PF00610.21 CCF31839.1 - 5.5e-15 55.2 0.0 1.2e-14 54.1 0.0 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Mucin PF01456.17 CCF31839.1 - 0.27 11.2 2.9 0.6 10.1 2.9 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein GMC_oxred_N PF00732.19 CCF31840.1 - 1e-36 126.9 0.0 1.1e-36 126.7 0.0 1.0 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.12 CCF31840.1 - 4.8e-05 22.6 0.1 6.4e-05 22.2 0.1 1.1 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 CCF31840.1 - 0.0011 18.2 0.0 0.0011 18.2 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CCF31840.1 - 0.0028 16.9 0.0 0.0042 16.3 0.0 1.2 1 0 0 1 1 1 1 Thi4 family Pyr_redox PF00070.27 CCF31840.1 - 0.027 15.0 0.0 0.046 14.3 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 CCF31840.1 - 0.035 14.4 0.0 0.052 13.8 0.0 1.2 1 0 0 1 1 1 0 TrkA-N domain DAO PF01266.24 CCF31840.1 - 0.038 13.6 0.1 0.038 13.6 0.1 1.2 1 1 0 1 1 1 0 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CCF31840.1 - 0.039 14.2 0.1 0.097 12.9 0.1 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 CCF31840.1 - 0.06 12.4 0.0 0.086 11.9 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain ApbA PF02558.16 CCF31840.1 - 0.066 12.9 0.1 0.12 12.0 0.1 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA PSD1 PF07587.11 CCF31840.1 - 0.069 12.6 0.0 0.096 12.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1553) HI0933_like PF03486.14 CCF31840.1 - 0.17 10.6 0.0 0.23 10.1 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein GIDA PF01134.22 CCF31840.1 - 0.17 10.9 0.0 0.17 10.9 0.0 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A CBM_35 PF16990.5 CCF31841.1 - 0.00021 21.5 0.1 0.00025 21.3 0.1 1.1 1 0 0 1 1 1 1 Carbohydrate binding module (family 35) HMG_CoA_synt_C PF08540.10 CCF31844.1 - 8.6e-53 179.8 0.0 9.5e-53 179.6 0.0 1.0 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal NADH-u_ox-rdase PF10785.9 CCF31845.1 - 4.5e-29 100.9 0.1 1.1e-28 99.8 0.1 1.6 2 0 0 2 2 2 1 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit NADH_u_ox_C PF12853.7 CCF31845.1 - 3.4e-25 87.8 0.0 5.2e-25 87.2 0.0 1.2 1 0 0 1 1 1 1 C-terminal of NADH-ubiquinone oxidoreductase 21 kDa subunit AAA PF00004.29 CCF31846.1 - 1.6e-15 57.7 0.0 3e-15 56.8 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CCF31846.1 - 6.8e-06 26.6 2.1 4.9e-05 23.8 0.8 2.8 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 CCF31846.1 - 3.5e-05 24.1 0.6 0.0023 18.2 0.1 2.5 1 1 1 2 2 2 2 AAA domain AAA_5 PF07728.14 CCF31846.1 - 0.037 14.0 0.0 0.096 12.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Tannase PF07519.11 CCF31848.1 - 3.8e-54 184.4 0.4 4.5e-54 184.1 0.4 1.1 1 0 0 1 1 1 1 Tannase and feruloyl esterase Abhydrolase_1 PF00561.20 CCF31848.1 - 0.017 14.7 0.0 0.041 13.5 0.0 1.6 2 0 0 2 2 2 0 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CCF31848.1 - 0.02 14.1 0.1 0.026 13.8 0.1 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 MFS_1 PF07690.16 CCF31849.1 - 7.8e-19 67.8 8.1 8.8e-19 67.6 8.1 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF31849.1 - 2.8e-12 46.3 6.4 3.1e-12 46.1 6.2 1.2 1 1 0 1 1 1 1 Sugar (and other) transporter TRI12 PF06609.13 CCF31849.1 - 7.4e-06 24.7 4.2 7.5e-06 24.6 4.2 1.0 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_2 PF13347.6 CCF31849.1 - 0.0016 17.1 1.2 0.0016 17.1 1.2 1.3 1 1 0 1 1 1 1 MFS/sugar transport protein DUF202 PF02656.15 CCF31849.1 - 0.94 10.0 5.7 1.4 9.4 1.9 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF202) Rubi_NSP_C PF12601.8 CCF31850.1 - 0.039 14.1 0.9 0.096 12.8 0.1 2.1 2 0 0 2 2 2 0 Rubivirus non-structural protein JTB PF05439.12 CCF31850.1 - 0.31 11.1 1.1 3.6 7.7 0.1 2.1 1 1 1 2 2 2 0 Jumping translocation breakpoint protein (JTB) YqjK PF13997.6 CCF31850.1 - 0.44 10.8 3.5 0.38 11.0 0.9 2.0 1 1 1 2 2 2 0 YqjK-like protein TPR_1 PF00515.28 CCF31851.1 - 3.6e-13 48.7 2.2 0.006 16.3 0.1 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 CCF31851.1 - 1.6e-12 46.5 4.2 0.005 16.9 0.0 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 CCF31851.1 - 3.7e-09 36.1 1.5 0.047 13.9 0.1 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 CCF31851.1 - 7.1e-09 35.2 2.7 0.00025 20.7 0.4 3.1 2 1 1 3 3 3 3 TPR repeat TPR_16 PF13432.6 CCF31851.1 - 9.1e-07 29.4 9.1 0.0025 18.4 3.1 2.2 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 CCF31851.1 - 9.1e-07 28.8 0.8 0.00063 19.9 0.4 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 CCF31851.1 - 2.7e-06 27.8 3.6 0.00034 21.0 0.9 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 CCF31851.1 - 4.6e-05 23.9 5.7 0.78 10.7 1.3 3.3 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.6 CCF31851.1 - 0.0005 19.9 0.1 1.2 9.3 0.0 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat STI1 PF17830.1 CCF31851.1 - 0.00062 19.6 8.2 0.00062 19.6 8.2 2.3 2 0 0 2 2 2 1 STI1 domain TPR_9 PF13371.6 CCF31851.1 - 0.0042 17.2 0.5 0.037 14.2 0.4 2.1 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 CCF31851.1 - 0.0066 16.7 3.3 0.086 13.1 0.9 2.8 1 1 1 2 2 2 1 Tetratricopeptide repeat BTAD PF03704.17 CCF31851.1 - 0.034 14.6 0.9 0.072 13.5 0.6 1.5 1 1 0 1 1 1 0 Bacterial transcriptional activator domain TPR_10 PF13374.6 CCF31851.1 - 0.061 13.2 1.8 0.58 10.1 0.2 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat XPC-binding PF09280.11 CCF31851.1 - 0.11 12.3 4.2 0.087 12.6 2.2 1.8 2 0 0 2 2 2 0 XPC-binding domain TPR_6 PF13174.6 CCF31851.1 - 0.32 11.7 3.9 1.8 9.4 0.3 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat GerD PF17898.1 CCF31851.1 - 0.69 9.9 2.3 1.4 8.9 0.9 2.0 2 0 0 2 2 2 0 Spore germination GerD central core domain ABC_tran PF00005.27 CCF31852.1 - 2.3e-32 112.4 0.0 4.2e-32 111.5 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 CCF31852.1 - 9.7e-24 84.5 2.7 9.7e-24 84.5 2.7 2.0 2 0 0 2 2 2 1 ABC transporter transmembrane region SMC_N PF02463.19 CCF31852.1 - 4.3e-05 23.1 0.0 0.00016 21.2 0.0 1.7 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain PAM2 PF07145.15 CCF31852.1 - 0.00078 19.0 0.3 0.027 14.2 0.1 2.6 2 0 0 2 2 2 1 Ataxin-2 C-terminal region RsgA_GTPase PF03193.16 CCF31852.1 - 0.0057 16.6 0.1 0.012 15.5 0.1 1.5 1 0 0 1 1 1 1 RsgA GTPase T2SSE PF00437.20 CCF31852.1 - 0.024 13.7 0.1 0.45 9.5 0.0 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_30 PF13604.6 CCF31852.1 - 0.034 13.9 0.0 0.092 12.5 0.0 1.7 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 CCF31852.1 - 0.07 12.4 0.1 0.17 11.1 0.1 1.6 1 0 0 1 1 1 0 Zeta toxin AAA_29 PF13555.6 CCF31852.1 - 0.1 12.3 0.4 0.29 10.9 0.4 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.6 CCF31852.1 - 0.15 12.3 0.0 0.57 10.5 0.0 2.0 1 1 0 1 1 1 0 AAA domain AAA_15 PF13175.6 CCF31852.1 - 0.15 11.7 0.0 0.27 10.9 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain TraF PF13728.6 CCF31854.1 - 7.7 6.3 8.4 7.7 6.3 8.4 1.1 1 0 0 1 1 1 0 F plasmid transfer operon protein Acyl-CoA_ox_N PF14749.6 CCF31855.1 - 1.5e-15 57.9 0.1 1.9e-15 57.5 0.1 1.1 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal HTH_Tnp_Tc5 PF03221.16 CCF31857.1 - 7.2e-10 38.7 0.0 1.3e-09 37.9 0.0 1.4 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain Glyco_hydro_61 PF03443.14 CCF31858.1 - 6.7e-43 147.0 0.0 8e-43 146.8 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 Peptidase_C53 PF05550.11 CCF31858.1 - 0.1 12.3 0.0 0.14 11.8 0.0 1.2 1 0 0 1 1 1 0 Pestivirus Npro endopeptidase C53 Glyco_hydro_61 PF03443.14 CCF31859.1 - 2.2e-44 151.8 0.0 8.7e-41 140.1 0.0 2.1 1 1 1 2 2 2 2 Glycosyl hydrolase family 61 bZIP_1 PF00170.21 CCF31860.1 - 5.1e-07 29.7 9.9 7.7e-07 29.1 9.9 1.2 1 0 0 1 1 1 1 bZIP transcription factor ASD2 PF08687.11 CCF31860.1 - 0.0073 15.9 1.9 0.0086 15.7 1.9 1.1 1 0 0 1 1 1 1 Apx/Shroom domain ASD2 bZIP_2 PF07716.15 CCF31860.1 - 0.0094 16.0 10.0 0.0094 16.0 10.0 1.6 2 0 0 2 2 2 1 Basic region leucine zipper Tmemb_cc2 PF10267.9 CCF31860.1 - 0.021 14.0 3.6 0.024 13.8 3.6 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein DUF812 PF05667.11 CCF31860.1 - 0.021 13.7 4.2 0.027 13.4 4.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF812) PRP1_N PF06424.12 CCF31860.1 - 0.044 14.2 4.5 0.06 13.7 4.5 1.2 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal Macoilin PF09726.9 CCF31860.1 - 0.067 11.7 8.6 0.078 11.5 8.6 1.0 1 0 0 1 1 1 0 Macoilin family CDC45 PF02724.14 CCF31860.1 - 0.12 10.7 7.0 0.14 10.4 7.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Apt1 PF10351.9 CCF31860.1 - 0.18 10.6 7.4 0.18 10.6 7.4 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Red1 PF07964.11 CCF31860.1 - 0.63 8.2 8.4 0.8 7.9 8.4 1.0 1 0 0 1 1 1 0 Rec10 / Red1 DUF4407 PF14362.6 CCF31860.1 - 0.89 8.8 3.1 1.2 8.5 3.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Peptidase_S64 PF08192.11 CCF31860.1 - 1.5 7.2 6.2 1.7 7.1 6.2 1.1 1 0 0 1 1 1 0 Peptidase family S64 Presenilin PF01080.17 CCF31860.1 - 2.5 6.8 6.6 3.1 6.5 6.6 1.1 1 0 0 1 1 1 0 Presenilin 2-Hacid_dh PF00389.30 CCF31862.1 - 3.5e-11 42.9 0.0 3.8e-11 42.8 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain SMC_N PF02463.19 CCF31863.1 - 0.16 11.4 0.1 0.18 11.2 0.1 1.1 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain Actin PF00022.19 CCF31864.1 - 9.7e-06 24.4 0.0 1.9e-05 23.5 0.0 1.7 1 1 0 1 1 1 1 Actin MFS_1 PF07690.16 CCF31867.1 - 7.7e-25 87.5 56.4 8e-21 74.3 34.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Deltameth_res PF16020.5 CCF31867.1 - 4.9 7.1 5.8 47 4.0 0.1 3.7 3 1 1 4 4 4 0 Deltamethrin resistance TssN PF17555.2 CCF31867.1 - 7.5 5.8 10.2 0.088 12.2 1.6 2.1 2 1 0 2 2 2 0 Type VI secretion system, TssN FMN_red PF03358.15 CCF31868.1 - 5.1e-09 36.1 0.0 6.8e-09 35.7 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 CCF31868.1 - 4.7e-06 26.4 0.0 5.8e-06 26.1 0.0 1.1 1 0 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_1 PF00258.25 CCF31868.1 - 2.7e-05 24.4 0.1 0.00048 20.4 0.1 2.1 1 1 0 1 1 1 1 Flavodoxin Flavodoxin_5 PF12724.7 CCF31868.1 - 0.0017 18.6 0.0 0.037 14.3 0.0 2.1 1 1 1 2 2 2 1 Flavodoxin domain Methyltransf_22 PF13383.6 CCF31869.1 - 7.7e-18 65.0 0.0 1.1e-17 64.5 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_21 PF05050.12 CCF31869.1 - 7.2e-06 26.1 0.0 9.8e-06 25.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase FkbM domain BTRD1 PF17660.1 CCF31869.1 - 0.018 14.8 0.0 0.07 13.0 0.0 2.0 2 0 0 2 2 2 0 Bacterial tandem repeat domain 1 She9_MDM33 PF05546.11 CCF31870.1 - 0.084 12.7 0.1 0.16 11.7 0.1 1.4 1 0 0 1 1 1 0 She9 / Mdm33 family CTP_transf_like PF01467.26 CCF31871.1 - 7.6e-07 29.4 0.0 2.6e-06 27.7 0.0 1.8 1 1 0 1 1 1 1 Cytidylyltransferase-like FAD_syn PF06574.12 CCF31871.1 - 0.16 11.8 0.0 0.29 11.0 0.0 1.4 1 0 0 1 1 1 0 FAD synthetase MFS_1 PF07690.16 CCF31872.1 - 1.4e-23 83.4 42.1 7.1e-19 67.9 25.3 2.4 2 1 0 2 2 2 2 Major Facilitator Superfamily HILPDA PF15220.6 CCF31872.1 - 2.1 8.5 5.3 7.9 6.7 0.1 3.1 3 0 0 3 3 3 0 Hypoxia-inducible lipid droplet-associated AMP-binding PF00501.28 CCF31878.1 - 4.4e-22 78.3 0.0 6.4e-22 77.7 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme DUF3328 PF11807.8 CCF31879.1 - 2.5e-20 73.2 1.4 3e-20 73.0 1.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) ADH_N PF08240.12 CCF31880.1 - 2e-09 37.3 0.0 4e-09 36.3 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCF31880.1 - 1.1e-08 35.1 0.0 2.5e-08 34.0 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase FSH1 PF03959.13 CCF31881.1 - 3.1e-31 108.7 0.0 3.8e-31 108.4 0.0 1.0 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_6 PF12697.7 CCF31881.1 - 1.6e-05 25.7 0.8 1.8e-05 25.5 0.8 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 CCF31881.1 - 0.0039 17.0 0.0 0.069 12.9 0.0 2.4 2 1 0 2 2 2 1 Phospholipase/Carboxylesterase Abhydrolase_1 PF00561.20 CCF31881.1 - 0.21 11.2 0.4 20 4.7 0.0 2.8 2 1 0 3 3 3 0 alpha/beta hydrolase fold PhyH PF05721.13 CCF31882.1 - 6.5e-19 69.0 0.0 1e-18 68.4 0.0 1.3 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) E2 PF08199.11 CCF31882.1 - 0.042 13.8 0.1 0.084 12.8 0.1 1.4 1 0 0 1 1 1 0 Bacteriophage E2-like protein GCH_III PF05165.12 CCF31882.1 - 0.16 11.2 0.1 0.25 10.6 0.1 1.2 1 0 0 1 1 1 0 GTP cyclohydrolase III Atg8 PF02991.16 CCF31883.1 - 1e-38 131.7 0.1 1.1e-38 131.6 0.1 1.0 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 CCF31883.1 - 1.5e-06 28.5 0.0 1.8e-06 28.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Cu-oxidase_2 PF07731.14 CCF31885.1 - 4.4e-13 49.1 0.2 6.2e-13 48.7 0.2 1.2 1 0 0 1 1 1 1 Multicopper oxidase CLP1_P PF16575.5 CCF31889.1 - 0.0034 17.2 0.0 0.0038 17.0 0.0 1.0 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop TauD PF02668.16 CCF31892.1 - 5.9e-52 177.1 0.9 6.7e-52 176.9 0.9 1.0 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Sld5 PF05916.11 CCF31893.1 - 8.9e-20 71.2 0.0 1.8e-19 70.2 0.0 1.5 2 0 0 2 2 2 1 GINS complex protein Sod_Fe_C PF02777.18 CCF31894.1 - 1.8e-38 130.8 0.1 3.1e-38 130.0 0.1 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 CCF31894.1 - 1.9e-30 105.2 1.0 3.2e-30 104.4 1.0 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain COesterase PF00135.28 CCF31898.1 - 5.4e-86 289.5 0.0 6e-86 289.3 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CCF31898.1 - 0.00029 20.8 0.1 0.0018 18.1 0.0 2.1 2 0 0 2 2 2 1 alpha/beta hydrolase fold La PF05383.17 CCF31899.1 - 3.8e-20 71.7 0.1 8.5e-20 70.6 0.0 1.6 2 0 0 2 2 2 1 La domain RRM_1 PF00076.22 CCF31899.1 - 1.3e-09 37.7 0.2 2.5e-09 36.8 0.2 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) S4 PF01479.25 CCF31900.1 - 5.5e-13 48.4 0.0 1.2e-12 47.3 0.0 1.6 1 0 0 1 1 1 1 S4 domain S4_2 PF13275.6 CCF31900.1 - 0.011 15.6 0.0 0.023 14.5 0.0 1.4 1 0 0 1 1 1 0 S4 domain IPP-2 PF04979.14 CCF31900.1 - 6 7.6 10.4 0.44 11.3 3.5 2.5 2 0 0 2 2 2 0 Protein phosphatase inhibitor 2 (IPP-2) Septin PF00735.18 CCF31901.1 - 1.8e-118 394.9 0.2 1.8e-118 394.9 0.2 1.7 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 CCF31901.1 - 7e-08 32.5 1.2 1.3e-07 31.7 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CCF31901.1 - 1.2e-05 24.9 0.9 0.0019 17.8 0.0 2.9 3 0 0 3 3 3 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 CCF31901.1 - 3.8e-05 23.7 2.2 0.0025 17.7 0.6 3.2 2 1 0 2 2 2 1 RsgA GTPase ABC_tran PF00005.27 CCF31901.1 - 0.00019 21.9 1.5 0.036 14.6 0.0 2.6 2 0 0 2 2 2 1 ABC transporter Roc PF08477.13 CCF31901.1 - 0.0027 17.9 0.0 0.006 16.8 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.6 CCF31901.1 - 0.0028 18.0 0.0 0.0073 16.7 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AIG1 PF04548.16 CCF31901.1 - 0.0036 16.7 1.7 0.0071 15.7 0.0 2.2 2 0 0 2 2 2 1 AIG1 family AAA_22 PF13401.6 CCF31901.1 - 0.0096 16.2 1.0 0.038 14.3 0.0 2.6 2 2 0 2 2 2 1 AAA domain Ras PF00071.22 CCF31901.1 - 0.01 15.5 0.1 0.056 13.0 0.0 2.2 2 0 0 2 2 2 1 Ras family AAA_29 PF13555.6 CCF31901.1 - 0.018 14.8 0.0 0.034 13.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_24 PF13479.6 CCF31901.1 - 0.062 13.0 0.0 0.22 11.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.18 CCF31901.1 - 0.068 12.5 0.0 0.17 11.2 0.0 1.6 1 0 0 1 1 1 0 FtsK/SpoIIIE family RNA_helicase PF00910.22 CCF31901.1 - 0.084 13.3 0.5 0.78 10.2 0.0 2.5 2 0 0 2 2 2 0 RNA helicase Caldesmon PF02029.15 CCF31901.1 - 0.11 11.2 18.4 0.18 10.5 18.4 1.3 1 0 0 1 1 1 0 Caldesmon AAA_7 PF12775.7 CCF31901.1 - 0.13 11.7 0.0 0.26 10.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Dynamin_N PF00350.23 CCF31901.1 - 0.2 11.7 8.9 1.2 9.2 0.0 3.6 3 1 0 3 3 3 0 Dynamin family Exonuc_VII_L PF02601.15 CCF31901.1 - 0.44 10.1 6.9 0.72 9.4 6.9 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit ATP_bind_1 PF03029.17 CCF31901.1 - 1.6 8.4 6.2 4.1 7.1 0.0 3.1 2 1 1 3 3 3 0 Conserved hypothetical ATP binding protein Atg14 PF10186.9 CCF31901.1 - 7.3 5.6 8.6 12 4.8 8.6 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF87 PF01935.17 CCF31901.1 - 9.9 6.2 7.7 6.3 6.8 0.0 2.6 3 0 0 3 3 2 0 Helicase HerA, central domain adh_short PF00106.25 CCF31902.1 - 6.8e-26 90.9 0.1 1e-25 90.4 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF31902.1 - 1.4e-16 60.7 0.9 2.9e-16 59.8 0.9 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF31902.1 - 6.2e-05 23.0 1.2 0.012 15.6 0.2 2.2 2 0 0 2 2 2 2 KR domain Epimerase PF01370.21 CCF31902.1 - 0.0016 17.9 0.0 0.39 10.1 0.0 2.2 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family DUF2939 PF11159.8 CCF31902.1 - 0.0037 17.6 0.1 0.007 16.8 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2939) NAD_binding_10 PF13460.6 CCF31902.1 - 0.0044 16.9 0.4 0.0072 16.2 0.4 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Eno-Rase_NADH_b PF12242.8 CCF31902.1 - 0.049 13.4 0.0 0.1 12.4 0.0 1.5 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase THF_DHG_CYH_C PF02882.19 CCF31902.1 - 0.057 12.7 0.0 0.096 12.0 0.0 1.3 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Shikimate_DH PF01488.20 CCF31902.1 - 0.082 13.0 0.0 0.15 12.1 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase PALP PF00291.25 CCF31904.1 - 1.4e-33 116.5 0.0 2.6e-33 115.7 0.0 1.4 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Rhodanese PF00581.20 CCF31904.1 - 1.4e-08 35.2 0.0 4e-08 33.7 0.0 1.8 1 0 0 1 1 1 1 Rhodanese-like domain MFS_1 PF07690.16 CCF31905.1 - 9.9e-40 136.5 44.9 2.1e-39 135.4 43.2 2.4 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 CCF31905.1 - 2.8e-18 65.7 22.8 3.7e-18 65.3 22.8 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 CCF31905.1 - 1.5e-16 60.3 6.1 1.5e-16 60.3 6.1 2.8 2 1 1 3 3 3 1 Sugar (and other) transporter Fungal_trans_2 PF11951.8 CCF31906.1 - 1.4e-08 33.9 0.7 1.8e-05 23.7 0.0 2.3 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF31906.1 - 0.0021 18.1 9.1 0.005 16.9 9.1 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Septin PF00735.18 CCF31907.1 - 4.3e-105 351.0 0.1 4.3e-105 351.0 0.1 1.6 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 CCF31907.1 - 1.3e-05 25.2 0.0 3.4e-05 23.9 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CCF31907.1 - 2.9e-05 24.0 0.0 9.8e-05 22.3 0.0 1.8 1 0 0 1 1 1 1 RsgA GTPase Dynamin_N PF00350.23 CCF31907.1 - 0.0007 19.7 1.2 0.79 9.8 0.0 2.9 2 1 1 3 3 3 2 Dynamin family ABC_tran PF00005.27 CCF31907.1 - 0.021 15.3 0.0 0.27 11.8 0.0 2.5 2 1 0 2 2 2 0 ABC transporter DUF4522 PF15022.6 CCF31907.1 - 0.065 13.5 2.1 0.1 12.9 0.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4522) AAA_22 PF13401.6 CCF31907.1 - 0.089 13.1 0.1 0.34 11.2 0.1 2.2 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 CCF31907.1 - 1.6 8.9 4.8 5.1 7.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain DUF1768 PF08719.11 CCF31908.1 - 2.5e-53 180.6 0.3 3e-53 180.4 0.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) adh_short_C2 PF13561.6 CCF31909.1 - 6.5e-58 196.0 0.2 7.5e-58 195.8 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF31909.1 - 3.9e-41 140.6 0.1 4.9e-41 140.3 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF31909.1 - 1.3e-06 28.4 1.1 2e-06 27.9 1.1 1.2 1 0 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 CCF31909.1 - 0.00045 20.1 0.2 0.00077 19.4 0.2 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Methyltransf_25 PF13649.6 CCF31909.1 - 0.0082 16.8 0.0 0.016 15.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain ChuX_HutX PF06228.13 CCF31909.1 - 0.042 13.6 0.0 4.6 7.0 0.0 2.3 1 1 1 2 2 2 0 Haem utilisation ChuX/HutX UDPG_MGDP_dh_N PF03721.14 CCF31909.1 - 0.047 13.3 0.1 0.076 12.6 0.1 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain THF_DHG_CYH_C PF02882.19 CCF31909.1 - 0.055 12.8 0.0 0.17 11.2 0.0 1.8 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Polysacc_synt_2 PF02719.15 CCF31909.1 - 0.059 12.5 0.0 0.087 11.9 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein ICL PF00463.21 CCF31910.1 - 1.6e-200 667.1 0.0 1.9e-200 666.9 0.0 1.0 1 0 0 1 1 1 1 Isocitrate lyase family Citrate_synt PF00285.21 CCF31911.1 - 2.3e-101 339.5 0.0 2.7e-101 339.2 0.0 1.1 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain Sulfotransfer_4 PF17784.1 CCF31912.1 - 6.7e-38 130.7 0.1 8.5e-38 130.3 0.1 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 CCF31912.1 - 0.00076 19.9 0.7 0.028 14.8 0.7 2.1 1 1 0 1 1 1 1 Sulfotransferase family B12D PF06522.11 CCF31914.1 - 0.074 12.9 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 NADH-ubiquinone reductase complex 1 MLRQ subunit WSC PF01822.19 CCF31915.1 - 1.1e-06 28.7 7.5 2e-06 27.9 7.5 1.4 1 0 0 1 1 1 1 WSC domain RIO1 PF01163.22 CCF31916.1 - 2.4e-69 232.7 0.2 5e-69 231.7 0.0 1.6 2 0 0 2 2 2 1 RIO1 family APH PF01636.23 CCF31916.1 - 0.0029 17.6 0.1 2 8.3 0.0 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 CCF31916.1 - 0.024 14.0 0.0 0.62 9.4 0.0 2.4 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family YL1 PF05764.13 CCF31916.1 - 8.1 6.5 30.0 3 7.9 4.1 2.3 2 0 0 2 2 2 0 YL1 nuclear protein Kelch_5 PF13854.6 CCF31917.1 - 4e-15 55.4 13.5 1.6e-09 37.5 0.3 5.4 5 0 0 5 5 5 3 Kelch motif Kelch_4 PF13418.6 CCF31917.1 - 7.7e-13 48.2 6.2 0.00041 20.3 0.2 4.6 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_6 PF13964.6 CCF31917.1 - 2.5e-09 37.1 15.0 0.18 12.1 0.1 5.0 4 1 1 5 5 5 4 Kelch motif Kelch_1 PF01344.25 CCF31917.1 - 3e-05 23.5 0.2 2.9 7.5 0.0 4.1 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 CCF31917.1 - 0.00032 20.6 10.7 0.26 11.3 0.2 4.9 6 0 0 6 6 6 2 Kelch motif Kelch_3 PF13415.6 CCF31917.1 - 0.00056 20.1 10.0 0.62 10.4 0.2 4.8 5 0 0 5 5 5 2 Galactose oxidase, central domain DUF3172 PF11371.8 CCF31917.1 - 0.15 11.8 0.0 0.24 11.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3172) Neurokinin_B PF03823.14 CCF31918.1 - 0.11 12.5 0.0 0.34 11.0 0.0 1.7 2 0 0 2 2 2 0 Neurokinin B SYF2 PF08231.12 CCF31919.1 - 1.5e-55 188.0 15.5 1.5e-55 188.0 15.5 1.8 2 0 0 2 2 2 1 SYF2 splicing factor Adenylsucc_synt PF00709.21 CCF31919.1 - 0.16 10.8 1.5 0.33 9.8 0.1 1.9 1 1 1 2 2 2 0 Adenylosuccinate synthetase Bravo_FIGEY PF13882.6 CCF31919.1 - 2.8 9.4 16.9 0.48 11.8 2.7 3.5 2 2 1 3 3 3 0 Bravo-like intracellular region ARD PF03079.14 CCF31919.1 - 9.3 6.4 9.0 0.38 10.9 0.9 2.6 1 1 2 3 3 3 0 ARD/ARD' family NAD_binding_10 PF13460.6 CCF31920.1 - 1.7e-06 28.1 0.0 1.9e-05 24.6 0.0 2.5 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CCF31920.1 - 1.9e-05 24.2 0.0 5.5e-05 22.7 0.0 1.7 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CCF31920.1 - 0.0018 17.3 0.0 0.041 12.9 0.0 2.4 3 0 0 3 3 3 1 3-beta hydroxysteroid dehydrogenase/isomerase family YEATS PF03366.16 CCF31922.1 - 5.4e-29 100.0 0.1 8.6e-29 99.3 0.1 1.3 1 0 0 1 1 1 1 YEATS family DarA_C PF18789.1 CCF31922.1 - 0.0045 17.3 0.1 0.019 15.3 0.0 2.1 2 0 0 2 2 2 1 Defence against restriction A C-terminal L_lactis_ph-MCP PF06673.11 CCF31922.1 - 0.18 10.7 2.8 0.26 10.2 2.8 1.1 1 0 0 1 1 1 0 Lactococcus lactis bacteriophage major capsid protein MerR-DNA-bind PF09278.11 CCF31922.1 - 0.19 12.3 3.1 0.43 11.1 3.1 1.5 1 0 0 1 1 1 0 MerR, DNA binding Ins_P5_2-kin PF06090.12 CCF31924.1 - 2.5e-48 165.2 0.3 4.7e-48 164.3 0.3 1.4 1 1 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase DUF1967 PF09269.11 CCF31924.1 - 0.14 12.1 0.1 0.31 11.0 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1967) SET PF00856.28 CCF31925.1 - 0.00069 20.0 0.2 0.53 10.6 0.2 3.0 1 1 0 1 1 1 1 SET domain ABC_tran PF00005.27 CCF31927.1 - 1.3e-48 165.0 0.4 3.8e-27 95.5 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC2_membrane_3 PF12698.7 CCF31927.1 - 2.1e-20 73.1 45.0 7.1e-13 48.4 20.6 2.8 2 1 0 2 2 2 2 ABC-2 family transporter protein AAA_21 PF13304.6 CCF31927.1 - 3.1e-19 69.9 8.1 5.6e-05 23.1 0.0 5.2 3 2 1 5 5 5 4 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CCF31927.1 - 3.1e-08 33.2 1.9 0.0012 18.5 0.1 3.2 4 0 0 4 4 2 2 P-loop containing region of AAA domain SMC_N PF02463.19 CCF31927.1 - 5.8e-08 32.4 2.9 0.27 10.6 0.0 4.2 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CCF31927.1 - 6.6e-07 30.0 0.5 0.043 14.3 0.0 2.3 2 0 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 CCF31927.1 - 2.4e-05 24.3 0.3 0.17 11.8 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase DUF4162 PF13732.6 CCF31927.1 - 9e-05 23.1 0.0 0.31 11.8 0.0 3.2 3 0 0 3 3 3 1 Domain of unknown function (DUF4162) AAA_15 PF13175.6 CCF31927.1 - 0.00015 21.6 0.0 0.72 9.5 0.1 3.1 3 0 0 3 3 3 1 AAA ATPase domain AAA_16 PF13191.6 CCF31927.1 - 0.0021 18.5 0.1 1.4 9.2 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain AAA_27 PF13514.6 CCF31927.1 - 0.0043 16.7 0.1 0.86 9.2 0.0 2.3 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 CCF31927.1 - 0.013 15.2 0.0 39 3.9 0.0 3.9 4 0 0 4 4 4 0 IstB-like ATP binding protein Rad17 PF03215.15 CCF31927.1 - 0.02 14.8 0.0 9.5 6.1 0.0 2.3 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_30 PF13604.6 CCF31927.1 - 0.023 14.4 1.2 4 7.1 0.0 2.7 2 1 0 2 2 2 0 AAA domain AAA_22 PF13401.6 CCF31927.1 - 0.025 14.9 0.1 5.4 7.3 0.1 2.8 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 CCF31927.1 - 0.033 13.4 0.2 7.8 5.7 0.1 2.5 2 0 0 2 2 2 0 Zeta toxin RNA_helicase PF00910.22 CCF31927.1 - 0.045 14.2 0.0 2.3 8.7 0.0 2.5 2 0 0 2 2 2 0 RNA helicase SRP54 PF00448.22 CCF31927.1 - 0.06 13.0 0.9 10 5.7 0.3 2.3 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_24 PF13479.6 CCF31927.1 - 0.077 12.7 0.2 12 5.5 0.1 2.3 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 CCF31927.1 - 0.12 12.9 0.1 7.6 7.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.17 CCF31927.1 - 0.15 12.1 2.0 3.2 7.8 0.0 2.5 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_PrkA PF08298.11 CCF31927.1 - 0.17 10.8 0.0 7.2 5.4 0.0 2.2 2 0 0 2 2 2 0 PrkA AAA domain AIG1 PF04548.16 CCF31927.1 - 1.8 7.9 3.2 2.5 7.4 0.7 2.2 2 0 0 2 2 2 0 AIG1 family AAA_28 PF13521.6 CCF31927.1 - 4.1 7.6 5.7 60 3.8 2.5 3.0 3 0 0 3 3 3 0 AAA domain MutS_V PF00488.21 CCF31929.1 - 6.8e-84 280.6 0.2 1.1e-83 279.9 0.2 1.3 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 CCF31929.1 - 7.8e-39 133.9 0.3 3.3e-38 131.8 0.3 2.1 2 0 0 2 2 2 1 MutS domain III MutS_II PF05188.17 CCF31929.1 - 1.4e-22 80.5 0.8 1.5e-21 77.2 0.0 2.7 3 0 0 3 3 3 1 MutS domain II MutS_I PF01624.20 CCF31929.1 - 6.4e-21 74.7 0.0 3.8e-20 72.2 0.0 2.2 2 0 0 2 2 2 1 MutS domain I MutS_IV PF05190.18 CCF31929.1 - 1.3e-18 67.1 3.6 1.7e-18 66.7 1.4 2.3 2 0 0 2 2 2 1 MutS family domain IV AAA_27 PF13514.6 CCF31929.1 - 0.079 12.5 0.0 0.2 11.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain tRNA_m1G_MT PF01746.21 CCF31930.1 - 2.4e-29 102.5 0.0 3.8e-21 75.7 0.0 2.3 2 0 0 2 2 2 2 tRNA (Guanine-1)-methyltransferase AflR PF08493.10 CCF31930.1 - 2.4 7.5 10.6 4.6 6.6 10.6 1.4 1 0 0 1 1 1 0 Aflatoxin regulatory protein DNA_primase_S PF01896.19 CCF31931.1 - 2.9e-63 213.1 0.1 4e-63 212.7 0.1 1.2 1 0 0 1 1 1 1 DNA primase small subunit Mem_trans PF03547.18 CCF31932.1 - 5.7e-18 64.5 6.1 7e-18 64.2 6.1 1.0 1 0 0 1 1 1 1 Membrane transport protein Phage_holin_1 PF04531.13 CCF31932.1 - 0.075 13.6 0.1 0.075 13.6 0.1 2.0 2 1 1 3 3 3 0 Bacteriophage holin RRM_1 PF00076.22 CCF31933.1 - 1.9e-14 53.2 0.0 2.7e-14 52.8 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CCF31933.1 - 0.002 17.7 0.0 0.003 17.2 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RTA1 PF04479.13 CCF31935.1 - 3e-56 190.3 8.4 3e-56 190.3 8.4 1.6 1 1 1 2 2 2 1 RTA1 like protein PhoLip_ATPase_C PF16212.5 CCF31935.1 - 3 7.5 15.2 0.45 10.2 1.5 2.1 2 0 0 2 2 2 0 Phospholipid-translocating P-type ATPase C-terminal Pyrophosphatase PF00719.19 CCF31937.1 - 6.8e-43 146.2 0.1 1e-42 145.7 0.1 1.3 1 0 0 1 1 1 1 Inorganic pyrophosphatase DUF3237 PF11578.8 CCF31938.1 - 2e-23 82.9 0.3 2.2e-17 63.3 0.0 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF3237) Grg1 PF11034.8 CCF31939.1 - 1.5e-31 108.4 11.6 1.7e-31 108.3 11.6 1.0 1 0 0 1 1 1 1 Glucose-repressible protein Grg1 Phe_tRNA-synt_N PF02912.18 CCF31939.1 - 0.061 13.3 0.1 0.11 12.5 0.1 1.5 1 1 0 1 1 1 0 Aminoacyl tRNA synthetase class II, N-terminal domain DUF3756 PF12581.8 CCF31939.1 - 0.071 13.0 0.3 0.12 12.3 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3756) Abhydrolase_4 PF08386.10 CCF31941.1 - 1.6e-17 63.5 0.0 4.4e-17 62.1 0.0 1.7 1 0 0 1 1 1 1 TAP-like protein Abhydrolase_1 PF00561.20 CCF31941.1 - 3.3e-17 63.0 0.1 1.8e-07 31.1 0.0 3.2 3 0 0 3 3 3 3 alpha/beta hydrolase fold Aldedh PF00171.22 CCF31942.1 - 4.6e-06 25.4 0.7 5.3e-06 25.2 0.7 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family CPSase_L_D2 PF02786.17 CCF31944.1 - 2.6e-68 229.7 0.0 3.7e-68 229.2 0.0 1.2 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_C PF02785.19 CCF31944.1 - 1.8e-27 95.5 0.0 3.4e-27 94.7 0.0 1.5 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain ATP-grasp PF02222.22 CCF31944.1 - 1e-11 44.7 0.2 2.3e-11 43.6 0.2 1.6 1 0 0 1 1 1 1 ATP-grasp domain Biotin_carb_N PF00289.22 CCF31944.1 - 1e-11 45.3 0.0 2.8e-11 43.9 0.0 1.8 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Dala_Dala_lig_C PF07478.13 CCF31944.1 - 2.2e-10 40.4 0.2 7.3e-10 38.7 0.1 1.8 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.14 CCF31944.1 - 2.2e-07 31.1 0.0 3.9e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl PF00364.22 CCF31944.1 - 1.6e-06 27.8 3.4 4.6e-06 26.4 3.2 1.9 1 1 0 1 1 1 1 Biotin-requiring enzyme ATPgrasp_ST PF14397.6 CCF31944.1 - 0.093 12.0 0.0 0.2 10.9 0.0 1.5 1 0 0 1 1 1 0 Sugar-transfer associated ATP-grasp DUF3182 PF11379.8 CCF31944.1 - 0.1 11.5 0.0 0.16 10.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3182) Carboxyl_trans PF01039.22 CCF31945.1 - 5.8e-31 107.7 0.0 6.5e-31 107.5 0.0 1.0 1 0 0 1 1 1 1 Carboxyl transferase domain Acetyltransf_3 PF13302.7 CCF31946.1 - 1.3e-07 32.3 0.1 2.3e-07 31.5 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Amidase PF01425.21 CCF31947.1 - 1.6e-90 304.3 0.0 2.2e-90 303.8 0.0 1.2 1 0 0 1 1 1 1 Amidase DUF3489 PF11994.8 CCF31947.1 - 0.16 12.1 0.1 0.38 10.9 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3489) Peptidase_S8 PF00082.22 CCF31948.1 - 1.3e-38 133.0 0.4 2e-38 132.4 0.4 1.3 1 0 0 1 1 1 1 Subtilase family fn3_5 PF06280.12 CCF31948.1 - 1.7e-15 57.7 0.3 3e-15 56.9 0.3 1.4 1 0 0 1 1 1 1 Fn3-like domain fn3_6 PF17766.1 CCF31948.1 - 0.11 12.7 0.1 0.3 11.3 0.1 1.7 1 1 0 1 1 1 0 Fibronectin type-III domain DJ-1_PfpI PF01965.24 CCF31949.1 - 1.3e-11 44.6 0.0 1.7e-11 44.2 0.0 1.1 1 0 0 1 1 1 1 DJ-1/PfpI family SH3_1 PF00018.28 CCF31950.1 - 0.028 14.0 0.1 0.073 12.7 0.1 1.7 1 0 0 1 1 1 0 SH3 domain SH3_9 PF14604.6 CCF31950.1 - 0.16 11.9 1.0 0.33 10.8 1.0 1.4 1 0 0 1 1 1 0 Variant SH3 domain Isochorismatase PF00857.20 CCF31952.1 - 4.5e-13 49.8 0.2 4.5e-13 49.8 0.2 1.1 1 0 0 1 1 1 1 Isochorismatase family Isochorismatase PF00857.20 CCF31953.1 - 2.8e-06 27.7 0.0 3.8e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 Isochorismatase family ADH_N PF08240.12 CCF31954.1 - 3.2e-27 94.6 2.4 6.6e-27 93.5 2.4 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCF31954.1 - 2.2e-15 56.8 0.0 3.2e-15 56.3 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 CCF31954.1 - 0.00016 21.3 0.5 0.0099 15.4 0.4 2.4 2 1 0 2 2 2 2 Glucose dehydrogenase C-terminus ATP-synt_G PF04718.15 CCF31955.1 - 7.7e-31 106.9 0.2 1.6e-30 105.8 0.0 1.6 2 0 0 2 2 2 1 Mitochondrial ATP synthase g subunit DDE_1 PF03184.19 CCF31956.1 - 1.2e-31 109.7 0.0 2.8e-31 108.5 0.0 1.7 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 CCF31956.1 - 1.6e-10 40.8 0.1 4e-10 39.6 0.1 1.7 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 CCF31956.1 - 3.4e-08 33.1 0.1 5.9e-08 32.3 0.1 1.4 1 0 0 1 1 1 1 helix-turn-helix, Psq domain DDE_3 PF13358.6 CCF31956.1 - 4.4e-05 23.3 0.0 0.00023 21.0 0.0 2.0 1 1 1 2 2 2 1 DDE superfamily endonuclease HTH_28 PF13518.6 CCF31956.1 - 0.0039 17.3 0.8 0.011 15.8 0.2 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.6 CCF31956.1 - 0.0089 15.8 0.1 0.027 14.3 0.1 1.8 1 0 0 1 1 1 1 Homeodomain-like domain HTH_7 PF02796.15 CCF31956.1 - 0.0099 15.9 0.6 0.019 15.0 0.6 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_Tnp_IS630 PF01710.16 CCF31956.1 - 0.036 14.1 0.0 0.068 13.2 0.0 1.4 1 0 0 1 1 1 0 Transposase HTH_Tnp_ISL3 PF13542.6 CCF31956.1 - 0.077 12.4 0.0 0.17 11.3 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 HTH_8 PF02954.19 CCF31956.1 - 0.088 12.6 0.1 0.23 11.3 0.1 1.8 1 0 0 1 1 1 0 Bacterial regulatory protein, Fis family Bclx_interact PF08945.10 CCF31957.1 - 0.17 11.7 0.9 1.3 8.8 0.3 2.2 2 0 0 2 2 2 0 Bcl-x interacting, BH3 domain CLP1_P PF16575.5 CCF31958.1 - 5.6e-31 107.8 0.0 8.8e-31 107.2 0.0 1.3 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop RNA_polI_A34 PF08208.11 CCF31960.1 - 4.2e-49 167.4 5.2 4.2e-49 167.4 5.2 5.7 3 2 1 4 4 4 1 DNA-directed RNA polymerase I subunit RPA34.5 Peptidase_M3 PF01432.20 CCF31961.1 - 3.5e-105 352.9 0.0 4e-105 352.7 0.0 1.0 1 0 0 1 1 1 1 Peptidase family M3 Cir_N PF10197.9 CCF31962.1 - 4.9e-10 39.4 3.5 6.5e-10 39.0 3.5 1.2 1 0 0 1 1 1 1 N-terminal domain of CBF1 interacting co-repressor CIR AAA PF00004.29 CCF31963.1 - 1.6e-47 161.2 0.0 1.2e-37 129.3 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 CCF31963.1 - 1.3e-09 38.2 0.0 2.1e-05 24.5 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_lid_3 PF17862.1 CCF31963.1 - 1.4e-09 37.6 0.1 3.1e-09 36.5 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain TIP49 PF06068.13 CCF31963.1 - 1.7e-07 30.8 0.0 0.017 14.3 0.0 2.3 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_22 PF13401.6 CCF31963.1 - 1.7e-07 31.5 0.0 0.00036 20.8 0.0 3.6 2 2 0 2 2 2 1 AAA domain AAA_16 PF13191.6 CCF31963.1 - 3.2e-06 27.7 0.1 0.039 14.3 0.0 2.7 2 1 0 2 2 2 2 AAA ATPase domain AAA_2 PF07724.14 CCF31963.1 - 4.1e-06 27.0 0.0 5.4e-05 23.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 CCF31963.1 - 4.5e-06 26.7 0.0 0.0021 18.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 CCF31963.1 - 2.5e-05 23.8 0.1 0.004 16.6 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI NB-ARC PF00931.22 CCF31963.1 - 3.8e-05 23.0 0.1 0.58 9.3 0.0 3.4 3 0 0 3 3 3 2 NB-ARC domain AAA_18 PF13238.6 CCF31963.1 - 4e-05 24.2 0.0 0.014 15.9 0.0 2.7 3 0 0 3 3 2 1 AAA domain AAA_24 PF13479.6 CCF31963.1 - 6.7e-05 22.7 0.0 0.033 13.9 0.0 2.8 2 1 0 2 2 2 1 AAA domain RuvB_N PF05496.12 CCF31963.1 - 8.6e-05 22.3 0.2 0.061 13.1 0.1 2.9 2 1 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 CCF31963.1 - 0.00014 22.2 0.0 0.28 11.6 0.0 2.7 2 0 0 2 2 2 2 RNA helicase AAA_33 PF13671.6 CCF31963.1 - 0.00018 21.7 0.0 0.33 11.1 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_7 PF12775.7 CCF31963.1 - 0.00018 21.1 0.1 0.014 14.9 0.0 2.6 3 0 0 3 3 2 1 P-loop containing dynein motor region ATPase_2 PF01637.18 CCF31963.1 - 0.0011 19.0 0.4 9.3 6.1 0.0 3.7 2 2 1 3 3 3 0 ATPase domain predominantly from Archaea ATPase PF06745.13 CCF31963.1 - 0.0015 17.9 0.2 0.13 11.6 0.1 2.6 2 1 0 2 2 2 1 KaiC IstB_IS21 PF01695.17 CCF31963.1 - 0.0019 17.9 0.0 0.037 13.8 0.0 2.6 2 0 0 2 2 2 1 IstB-like ATP binding protein TsaE PF02367.17 CCF31963.1 - 0.0026 17.7 0.0 0.48 10.4 0.0 2.4 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_25 PF13481.6 CCF31963.1 - 0.0063 16.1 0.2 4 7.0 0.1 2.7 2 1 0 2 2 2 1 AAA domain Sigma54_activat PF00158.26 CCF31963.1 - 0.0067 16.2 0.0 0.72 9.5 0.0 2.7 2 0 0 2 2 2 1 Sigma-54 interaction domain ABC_tran PF00005.27 CCF31963.1 - 0.012 16.1 0.1 0.058 13.9 0.1 2.2 2 0 0 2 2 1 0 ABC transporter AAA_19 PF13245.6 CCF31963.1 - 0.014 15.7 0.1 0.43 10.9 0.1 2.7 2 1 0 2 2 2 0 AAA domain CPT PF07931.12 CCF31963.1 - 0.015 15.1 0.0 0.22 11.3 0.0 2.4 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein AAA_11 PF13086.6 CCF31963.1 - 0.022 14.6 0.1 1.4 8.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_3 PF07726.11 CCF31963.1 - 0.047 13.5 0.1 0.49 10.3 0.0 2.5 3 0 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) KTI12 PF08433.10 CCF31963.1 - 0.05 13.0 0.0 1.6 8.1 0.0 2.4 2 0 0 2 2 2 0 Chromatin associated protein KTI12 NACHT PF05729.12 CCF31963.1 - 0.072 13.0 0.1 15 5.4 0.0 2.8 3 0 0 3 3 2 0 NACHT domain Parvo_NS1 PF01057.17 CCF31963.1 - 0.074 12.1 0.0 1.6 7.8 0.0 2.1 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 TniB PF05621.11 CCF31963.1 - 0.081 12.3 0.1 6.5 6.1 0.0 3.2 2 1 1 3 3 3 0 Bacterial TniB protein PhoH PF02562.16 CCF31963.1 - 0.086 12.3 0.0 0.98 8.8 0.0 2.2 2 0 0 2 2 2 0 PhoH-like protein AAA_28 PF13521.6 CCF31963.1 - 0.1 12.8 0.0 0.8 9.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 CCF31963.1 - 0.14 11.9 0.3 0.87 9.3 0.0 2.4 3 0 0 3 3 3 0 AAA domain YukD PF08817.10 CCF31964.1 - 0.00081 20.0 0.0 0.0013 19.4 0.0 1.3 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukD ubiquitin PF00240.23 CCF31964.1 - 0.0053 16.5 0.0 0.0081 15.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family DUF1923 PF09083.10 CCF31964.1 - 0.13 12.0 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1923) DNA_binding_1 PF01035.20 CCF31965.1 - 1.4e-30 105.2 0.0 1.8e-30 104.9 0.0 1.1 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain SO_alpha_A3 PF17806.1 CCF31965.1 - 0.12 12.7 0.1 0.18 12.2 0.1 1.2 1 0 0 1 1 1 0 Sarcosine oxidase A3 domain Defensin_big PF14862.6 CCF31966.1 - 0.092 13.1 0.1 0.33 11.3 0.0 1.9 2 0 0 2 2 2 0 Big defensin FAD_binding_4 PF01565.23 CCF31967.1 - 2.6e-18 66.1 1.6 2.6e-18 66.1 1.6 1.8 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.12 CCF31967.1 - 8e-14 51.5 1.0 2.1e-13 50.2 1.0 1.7 1 0 0 1 1 1 1 Berberine and berberine like PRTP PF01366.18 CCF31969.1 - 0.25 9.4 3.8 0.39 8.7 3.8 1.3 1 0 0 1 1 1 0 Herpesvirus processing and transport protein ARGLU PF15346.6 CCF31969.1 - 0.28 11.1 10.9 0.092 12.6 7.7 1.9 2 0 0 2 2 2 0 Arginine and glutamate-rich 1 FlxA PF14282.6 CCF31969.1 - 1.3 9.1 20.5 0.28 11.2 7.1 3.4 2 1 1 3 3 3 0 FlxA-like protein DUF4404 PF14357.6 CCF31969.1 - 1.8 9.3 6.6 5.8 7.6 5.4 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4404) Vir_act_alpha_C PF10400.9 CCF31969.1 - 2.7 8.7 6.2 37 5.1 5.0 2.8 2 1 0 2 2 2 0 Virulence activator alpha C-term PNP_UDP_1 PF01048.20 CCF31970.1 - 3e-08 33.2 0.1 5.5e-08 32.3 0.1 1.4 1 1 0 1 1 1 1 Phosphorylase superfamily Polyketide_cyc2 PF10604.9 CCF31971.1 - 7.4e-08 32.8 0.4 8.2e-08 32.6 0.4 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport DUF4520 PF15016.6 CCF31971.1 - 0.0081 16.2 0.1 0.016 15.2 0.0 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4520) FAD_binding_3 PF01494.19 CCF31972.1 - 2.3e-81 273.8 0.0 3.2e-81 273.3 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.12 CCF31972.1 - 3.4e-41 141.0 0.0 1e-40 139.5 0.0 1.8 2 0 0 2 2 2 1 Phenol hydroxylase, C-terminal dimerisation domain FAD_binding_2 PF00890.24 CCF31972.1 - 0.00045 19.4 0.2 0.0013 17.9 0.1 1.8 2 0 0 2 2 2 1 FAD binding domain Thi4 PF01946.17 CCF31972.1 - 0.0016 17.7 0.0 0.0028 17.0 0.0 1.3 1 0 0 1 1 1 1 Thi4 family DAO PF01266.24 CCF31972.1 - 0.004 16.8 2.6 0.091 12.3 0.3 2.4 1 1 0 2 2 2 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 CCF31972.1 - 0.006 16.0 0.0 0.014 14.7 0.0 1.5 2 0 0 2 2 2 1 FAD dependent oxidoreductase SE PF08491.10 CCF31972.1 - 0.0097 15.0 0.0 0.039 13.0 0.0 1.8 1 1 0 1 1 1 1 Squalene epoxidase Pyr_redox_2 PF07992.14 CCF31972.1 - 0.015 14.6 0.0 0.037 13.3 0.0 1.7 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Tagatose_6_P_K PF08013.11 CCF31972.1 - 0.02 13.6 0.0 0.032 12.9 0.0 1.1 1 0 0 1 1 1 0 Tagatose 6 phosphate kinase NAD_binding_8 PF13450.6 CCF31972.1 - 0.11 12.8 0.1 0.27 11.5 0.1 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain ApbA PF02558.16 CCF31972.1 - 0.2 11.3 0.2 0.57 9.8 0.1 1.8 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA SSF PF00474.17 CCF31973.1 - 2.8e-17 62.7 18.5 6.6e-17 61.5 18.5 1.6 1 1 0 1 1 1 1 Sodium:solute symporter family LysM PF01476.20 CCF31974.1 - 6.6e-21 74.1 0.2 7.1e-10 38.8 0.0 2.2 2 0 0 2 2 2 2 LysM domain F-box-like PF12937.7 CCF31976.1 - 3.1e-09 36.6 0.5 6e-09 35.7 0.5 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCF31976.1 - 2.5e-06 27.2 0.6 5.7e-06 26.1 0.6 1.6 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 CCF31976.1 - 0.038 13.9 0.0 0.087 12.7 0.0 1.5 1 0 0 1 1 1 0 F-box DUF2415 PF10313.9 CCF31976.1 - 0.12 12.3 0.0 0.41 10.6 0.0 1.9 1 0 0 1 1 1 0 Uncharacterised protein domain (DUF2415) Myosin_head PF00063.21 CCF31977.1 - 1.6e-49 168.7 0.3 1.8e-49 168.6 0.3 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) AAA_22 PF13401.6 CCF31977.1 - 0.0064 16.8 0.0 0.012 15.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CCF31977.1 - 0.018 15.5 0.0 0.027 14.8 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain NACHT PF05729.12 CCF31977.1 - 0.021 14.7 0.0 0.033 14.1 0.0 1.3 1 0 0 1 1 1 0 NACHT domain Sigma54_activat PF00158.26 CCF31977.1 - 0.024 14.4 0.0 0.039 13.7 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain RNA_helicase PF00910.22 CCF31977.1 - 0.045 14.2 0.1 0.13 12.7 0.1 1.8 1 0 0 1 1 1 0 RNA helicase Zeta_toxin PF06414.12 CCF31977.1 - 0.045 13.0 0.0 0.067 12.5 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin RsgA_GTPase PF03193.16 CCF31977.1 - 0.081 12.8 0.0 0.11 12.5 0.0 1.3 1 1 0 1 1 1 0 RsgA GTPase AAA_33 PF13671.6 CCF31977.1 - 0.081 13.1 0.0 2.4 8.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 CCF31977.1 - 0.081 12.9 0.0 0.13 12.3 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 CCF31977.1 - 0.11 13.0 0.1 0.19 12.2 0.1 1.4 1 0 0 1 1 1 0 ABC transporter PhoH PF02562.16 CCF31977.1 - 0.11 11.9 0.1 2.9 7.3 0.0 2.1 2 0 0 2 2 2 0 PhoH-like protein Mg_chelatase PF01078.21 CCF31977.1 - 0.16 11.4 0.0 0.24 10.8 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI VWA_N2 PF16164.5 CCF31979.1 - 0.64 10.2 3.2 1.7 8.8 3.2 1.7 1 1 0 1 1 1 0 VWA N-terminal His_Phos_2 PF00328.22 CCF31980.1 - 2.4e-05 23.9 0.5 0.0021 17.5 0.0 2.5 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 2) DUF3336 PF11815.8 CCF31982.1 - 1.3e-32 112.4 0.2 2.5e-32 111.4 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.22 CCF31982.1 - 2.2e-21 77.0 0.0 4.8e-21 75.9 0.0 1.5 1 0 0 1 1 1 1 Patatin-like phospholipase Arylesterase PF01731.20 CCF31984.1 - 0.00073 19.7 0.0 0.0061 16.7 0.0 2.4 1 1 0 1 1 1 1 Arylesterase Abi_C PF14355.6 CCF31984.1 - 0.046 13.8 0.1 0.1 12.7 0.1 1.5 1 0 0 1 1 1 0 Abortive infection C-terminus Fungal_trans PF04082.18 CCF31985.1 - 4.2e-07 29.3 0.2 7.7e-07 28.4 0.2 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain SPX PF03105.19 CCF31985.1 - 4 7.2 5.8 6.5 6.6 5.8 1.2 1 0 0 1 1 1 0 SPX domain Complex1_LYR PF05347.15 CCF31986.1 - 0.00093 19.2 1.2 0.00093 19.2 1.2 2.6 3 0 0 3 3 3 1 Complex 1 protein (LYR family) Acetyltransf_1 PF00583.25 CCF31987.1 - 1.7e-14 54.1 0.0 2e-14 53.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 CCF31987.1 - 1.9e-08 34.2 0.0 3.1e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.7 CCF31987.1 - 3.6e-07 30.5 0.0 5.4e-07 30.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CCF31987.1 - 2.5e-06 27.4 0.0 3.7e-06 26.9 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 CCF31987.1 - 0.003 18.2 0.0 0.0036 18.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 CCF31987.1 - 0.015 15.4 0.0 0.058 13.5 0.0 1.7 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain DUF4349 PF14257.6 CCF31987.1 - 0.026 13.9 0.0 0.036 13.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) ALMS_repeat PF18727.1 CCF31987.1 - 0.067 13.1 0.3 0.16 11.9 0.2 1.7 2 0 0 2 2 2 0 Alstrom syndrome repeat DUF4644 PF15486.6 CCF31987.1 - 0.12 12.1 0.0 0.28 10.9 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4644) PanZ PF12568.8 CCF31987.1 - 0.13 12.0 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain, PanZ 2-Hacid_dh_C PF02826.19 CCF31988.1 - 9.3e-41 139.1 0.0 1.6e-26 92.7 0.0 2.1 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 CCF31988.1 - 0.092 12.6 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain MFS_1 PF07690.16 CCF31989.1 - 4e-21 75.3 39.1 3.2e-20 72.4 32.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily BAF1_ABF1 PF04684.13 CCF31990.1 - 0.33 10.0 24.1 0.39 9.7 24.1 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DDHD PF02862.17 CCF31990.1 - 0.34 11.0 9.5 0.44 10.7 9.5 1.3 1 0 0 1 1 1 0 DDHD domain PAP1 PF08601.10 CCF31990.1 - 0.55 9.9 18.6 0.68 9.6 18.6 1.2 1 0 0 1 1 1 0 Transcription factor PAP1 SAPS PF04499.15 CCF31990.1 - 1.2 7.9 12.8 1.3 7.7 12.8 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Presenilin PF01080.17 CCF31990.1 - 2.4 6.8 17.4 2.8 6.6 17.4 1.1 1 0 0 1 1 1 0 Presenilin BSP_II PF05432.11 CCF31990.1 - 3.4 7.3 27.4 4.5 6.9 27.4 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Macoilin PF09726.9 CCF31990.1 - 3.7 6.0 18.4 4 5.9 18.4 1.0 1 0 0 1 1 1 0 Macoilin family Zip PF02535.22 CCF31990.1 - 4.1 6.5 9.2 5.2 6.2 9.2 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter RR_TM4-6 PF06459.12 CCF31990.1 - 4.4 7.1 18.5 6 6.6 18.5 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Vfa1 PF08432.10 CCF31990.1 - 4.6 7.5 23.1 7.2 6.9 23.1 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Menin PF05053.13 CCF31990.1 - 5.2 5.3 26.1 6 5.1 26.1 1.1 1 0 0 1 1 1 0 Menin GREB1 PF15782.5 CCF31990.1 - 6.7 3.7 11.2 7.1 3.6 11.2 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer CF222 PF15661.5 CCF31990.1 - 7.4 5.3 24.3 9.7 5.0 24.3 1.2 1 0 0 1 1 1 0 C6orf222, uncharacterised family E1_dh PF00676.20 CCF31991.1 - 1.3e-111 372.4 0.2 1.6e-111 372.0 0.2 1.0 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.6 CCF31991.1 - 0.002 17.4 0.1 0.004 16.4 0.1 1.4 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase WD40 PF00400.32 CCF31992.1 - 9.3e-14 51.6 1.3 5.2e-06 27.1 0.3 3.0 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF31992.1 - 5.7e-06 26.5 0.0 0.031 14.6 0.0 2.5 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 CCF31992.1 - 0.056 13.0 1.0 1.5 8.3 0.1 2.7 1 1 2 3 3 3 0 PQQ-like domain PQQ_3 PF13570.6 CCF31992.1 - 0.12 12.9 0.5 14 6.3 0.0 3.3 4 0 0 4 4 4 0 PQQ-like domain Nup160 PF11715.8 CCF31992.1 - 0.14 10.8 0.0 2.4 6.7 0.0 2.0 1 1 1 2 2 2 0 Nucleoporin Nup120/160 F-box-like PF12937.7 CCF31993.1 - 5.2e-13 48.7 0.9 1e-12 47.7 0.9 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCF31993.1 - 3.4e-06 26.8 2.5 6.3e-06 25.9 2.5 1.5 1 0 0 1 1 1 1 F-box domain WD40 PF00400.32 CCF31993.1 - 0.0002 22.1 0.2 0.001 19.8 0.2 2.3 2 0 0 2 2 2 1 WD domain, G-beta repeat F-box_5 PF18511.1 CCF31993.1 - 0.072 12.7 0.1 0.13 11.9 0.1 1.4 1 0 0 1 1 1 0 F-box Methyltr_RsmB-F PF01189.17 CCF31994.1 - 5.9e-77 257.8 0.0 8.7e-77 257.3 0.0 1.2 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltransf_25 PF13649.6 CCF31994.1 - 0.00096 19.8 0.1 0.0048 17.6 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Met_10 PF02475.16 CCF31994.1 - 0.0066 16.2 0.0 0.011 15.5 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein DUF2431 PF10354.9 CCF31994.1 - 0.0068 16.7 0.0 0.011 15.9 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF2431) Methyltransf_31 PF13847.6 CCF31994.1 - 0.0081 16.0 0.0 0.015 15.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 CCF31994.1 - 0.0087 15.8 0.0 0.015 15.1 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) FtsJ PF01728.19 CCF31994.1 - 0.018 15.2 0.0 0.031 14.4 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase Mitofilin PF09731.9 CCF31994.1 - 0.1 11.5 22.8 0.14 11.0 22.8 1.3 1 0 0 1 1 1 0 Mitochondrial inner membrane protein XRCC4 PF06632.12 CCF31996.1 - 3.2e-10 39.4 18.0 2.5e-09 36.5 18.0 1.9 1 1 0 1 1 1 1 DNA double-strand break repair and V(D)J recombination protein XRCC4 DUF3585 PF12130.8 CCF31996.1 - 0.0075 16.4 4.3 0.016 15.4 4.3 1.5 1 0 0 1 1 1 1 Bivalent Mical/EHBP Rab binding domain T3SS_needle_F PF09392.10 CCF31996.1 - 1.1 9.5 6.1 0.88 9.8 1.5 2.5 1 1 1 2 2 2 0 Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF Metal_resist PF13801.6 CCF31996.1 - 6.9 6.9 13.4 5.1 7.3 11.4 1.8 1 1 0 1 1 1 0 Heavy-metal resistance Aldo_ket_red PF00248.21 CCF31997.1 - 4.8e-44 150.7 0.0 9.8e-43 146.4 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family UPF0061 PF02696.14 CCF31998.1 - 1.6e-125 419.5 0.0 2e-125 419.2 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized ACR, YdiU/UPF0061 family Molybdopterin PF00384.22 CCF31999.1 - 5.1e-75 253.1 0.0 2.9e-73 247.3 0.0 2.1 1 1 0 1 1 1 1 Molybdopterin oxidoreductase NADH_dhqG_C PF09326.11 CCF31999.1 - 4.5e-19 68.9 0.0 1.2e-18 67.5 0.0 1.8 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit G, C-terminal NADH-G_4Fe-4S_3 PF10588.9 CCF31999.1 - 7.9e-17 60.5 0.2 7.9e-17 60.5 0.2 2.2 2 0 0 2 2 2 1 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region Fer2_4 PF13510.6 CCF31999.1 - 1.1e-15 57.4 0.2 3.4e-15 55.9 0.2 1.9 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer2 PF00111.27 CCF31999.1 - 0.00013 21.8 0.3 0.00013 21.8 0.3 2.1 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain TPP_enzyme_M PF00205.22 CCF31999.1 - 0.025 14.3 0.0 0.24 11.1 0.0 2.3 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain Fer4 PF00037.27 CCF31999.1 - 0.12 12.2 1.1 3.5 7.6 0.3 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_19 PF06902.11 CCF31999.1 - 0.59 10.2 2.4 9.1 6.5 2.4 2.5 1 1 0 1 1 1 0 Divergent 4Fe-4S mono-cluster RRM_1 PF00076.22 CCF32001.1 - 2.5e-18 65.6 0.0 3.6e-18 65.1 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SRP14 PF02290.15 CCF32002.1 - 9.4e-28 96.4 0.0 1.6e-27 95.7 0.0 1.3 2 0 0 2 2 2 1 Signal recognition particle 14kD protein MIF4G PF02854.19 CCF32003.1 - 1.4e-21 77.2 0.0 8.4e-21 74.6 0.0 2.0 2 0 0 2 2 2 1 MIF4G domain MA3 PF02847.17 CCF32003.1 - 2.1e-12 47.0 0.0 8e-12 45.1 0.0 2.1 1 0 0 1 1 1 1 MA3 domain ANF_receptor PF01094.28 CCF32003.1 - 0.066 12.3 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 Receptor family ligand binding region Sporozoite_P67 PF05642.11 CCF32003.1 - 2.8 5.9 11.5 4.6 5.2 11.5 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Pyr_redox_2 PF07992.14 CCF32004.1 - 4.1e-68 229.8 8.0 5.1e-68 229.4 8.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 CCF32004.1 - 3e-40 136.9 0.0 8.4e-40 135.5 0.0 1.8 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 CCF32004.1 - 5.5e-24 84.5 10.5 7e-21 74.6 0.8 3.2 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCF32004.1 - 2e-11 43.9 3.1 1.9e-06 28.0 0.4 2.6 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 CCF32004.1 - 5.9e-10 39.1 8.7 4e-09 36.3 0.2 2.6 2 1 1 3 3 3 2 FAD dependent oxidoreductase GIDA PF01134.22 CCF32004.1 - 3.4e-09 36.3 13.6 7e-08 31.9 4.4 2.8 2 2 0 2 2 2 2 Glucose inhibited division protein A FAD_binding_2 PF00890.24 CCF32004.1 - 2.3e-08 33.6 8.4 5.3e-07 29.1 2.8 2.8 3 0 0 3 3 3 2 FAD binding domain AlaDh_PNT_C PF01262.21 CCF32004.1 - 3.7e-07 29.7 3.4 0.012 14.9 0.3 2.9 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 CCF32004.1 - 7.3e-07 28.2 13.1 6.5e-05 21.8 1.6 4.1 4 0 0 4 4 4 2 HI0933-like protein Pyr_redox_3 PF13738.6 CCF32004.1 - 1.4e-06 27.8 2.2 0.0016 17.7 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CCF32004.1 - 1.5e-06 27.6 3.0 0.00034 20.0 0.1 2.4 2 0 0 2 2 2 2 Thi4 family DAO PF01266.24 CCF32004.1 - 1.1e-05 25.1 17.0 0.0048 16.5 1.4 4.1 4 0 0 4 4 4 2 FAD dependent oxidoreductase K_oxygenase PF13434.6 CCF32004.1 - 1.5e-05 24.3 0.4 0.24 10.5 0.0 2.9 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Lycopene_cycl PF05834.12 CCF32004.1 - 1.5e-05 24.2 1.2 0.0061 15.7 0.0 2.4 2 0 0 2 2 2 2 Lycopene cyclase protein 3HCDH_N PF02737.18 CCF32004.1 - 0.012 15.5 4.5 0.099 12.5 1.0 2.6 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_binding_3 PF01494.19 CCF32004.1 - 0.016 14.5 11.2 0.39 9.9 1.4 3.3 3 1 0 3 3 3 0 FAD binding domain XdhC_C PF13478.6 CCF32004.1 - 0.055 14.0 0.1 3.7 8.1 0.0 3.0 3 0 0 3 3 3 0 XdhC Rossmann domain FMO-like PF00743.19 CCF32004.1 - 0.11 11.0 0.6 0.2 10.1 0.6 1.4 1 0 0 1 1 1 0 Flavin-binding monooxygenase-like Trp_halogenase PF04820.14 CCF32004.1 - 0.22 10.3 6.4 0.14 10.9 0.7 2.2 2 0 0 2 2 2 0 Tryptophan halogenase NAD_binding_7 PF13241.6 CCF32004.1 - 0.24 11.9 6.3 3.7 8.0 0.1 3.1 3 1 0 3 3 2 0 Putative NAD(P)-binding UDPG_MGDP_dh_N PF03721.14 CCF32004.1 - 1.3 8.5 5.0 3.8 7.0 0.2 2.4 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Tyrosinase PF00264.20 CCF32005.1 - 7.6e-34 117.9 0.8 6.2e-33 115.0 0.8 2.2 1 1 0 1 1 1 1 Common central domain of tyrosinase Abhydrolase_1 PF00561.20 CCF32006.1 - 3e-25 89.3 0.0 2.5e-24 86.3 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_4 PF08386.10 CCF32006.1 - 5.5e-16 58.6 0.0 1.3e-15 57.4 0.0 1.6 1 0 0 1 1 1 1 TAP-like protein Hydrolase_4 PF12146.8 CCF32006.1 - 0.091 12.0 0.0 7.4 5.8 0.0 2.9 3 0 0 3 3 3 0 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 CCF32007.1 - 8.7e-29 100.9 0.0 1.4e-28 100.2 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 CCF32007.1 - 1.1e-05 24.5 0.0 4.6e-05 22.5 0.0 1.8 2 0 0 2 2 2 1 Carboxylesterase family AXE1 PF05448.12 CCF32007.1 - 0.00013 20.8 0.0 0.00029 19.6 0.0 1.5 2 0 0 2 2 2 1 Acetyl xylan esterase (AXE1) Abhydrolase_6 PF12697.7 CCF32007.1 - 0.00059 20.5 0.3 0.00082 20.0 0.3 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 CCF32007.1 - 0.0013 18.2 0.0 0.0024 17.4 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Say1_Mug180 PF10340.9 CCF32007.1 - 0.11 11.3 0.1 0.28 10.0 0.1 1.6 1 1 0 1 1 1 0 Steryl acetyl hydrolase AAA PF00004.29 CCF32008.1 - 6.6e-17 62.2 0.0 1.2e-16 61.3 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CCF32008.1 - 0.00073 20.0 0.1 0.0026 18.2 0.1 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 CCF32008.1 - 0.0024 17.9 0.0 0.0068 16.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 CCF32008.1 - 0.006 16.9 0.1 0.032 14.5 0.0 2.1 1 1 0 1 1 1 1 AAA domain HSP70 PF00012.20 CCF32009.1 - 4e-10 38.5 5.8 4.6e-10 38.3 5.8 1.0 1 0 0 1 1 1 1 Hsp70 protein ApoLp-III PF07464.11 CCF32009.1 - 0.0095 16.0 2.9 0.012 15.7 2.9 1.2 1 0 0 1 1 1 1 Apolipophorin-III precursor (apoLp-III) DUF4175 PF13779.6 CCF32009.1 - 0.17 9.8 6.8 0.18 9.7 6.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Lipoprotein_6 PF01441.19 CCF32009.1 - 1.2 9.2 7.2 1.1 9.3 0.7 2.0 1 1 1 2 2 2 0 Lipoprotein SRP68 PF16969.5 CCF32010.1 - 2.2e-201 670.7 10.6 2.5e-201 670.5 10.6 1.0 1 0 0 1 1 1 1 RNA-binding signal recognition particle 68 CENP-O PF09496.10 CCF32010.1 - 0.13 12.2 0.7 0.42 10.6 0.2 2.1 2 0 0 2 2 2 0 Cenp-O kinetochore centromere component Mis14 PF08641.12 CCF32010.1 - 4.4 7.6 7.2 0.43 10.9 0.3 2.7 3 0 0 3 3 3 0 Kinetochore protein Mis14 like PPR PF01535.20 CCF32011.1 - 2.2e-11 43.2 2.0 0.0034 17.5 0.1 7.2 8 0 0 8 8 8 2 PPR repeat PPR_2 PF13041.6 CCF32011.1 - 5.3e-11 42.5 0.0 0.14 12.4 0.0 6.7 7 1 1 8 8 8 3 PPR repeat family PPR_long PF17177.4 CCF32011.1 - 4.6e-07 29.4 0.1 0.0064 15.9 0.0 3.2 1 1 2 3 3 3 2 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 CCF32011.1 - 1.4e-05 24.7 0.8 2.8 7.7 0.0 4.4 4 0 0 4 4 4 3 PPR repeat TPR_14 PF13428.6 CCF32011.1 - 0.00017 22.2 15.4 1.6 9.8 0.0 7.8 7 1 0 7 7 6 2 Tetratricopeptide repeat PPR_3 PF13812.6 CCF32011.1 - 0.00018 21.5 0.0 0.27 11.4 0.0 3.5 3 0 0 3 3 3 1 Pentatricopeptide repeat domain TPR_19 PF14559.6 CCF32011.1 - 0.11 13.0 9.9 0.35 11.4 0.0 5.2 6 0 0 6 6 6 0 Tetratricopeptide repeat CENP-B_dimeris PF09026.10 CCF32011.1 - 0.21 12.0 4.9 0.8 10.1 4.9 1.9 1 0 0 1 1 1 0 Centromere protein B dimerisation domain PBP1_TM PF14812.6 CCF32011.1 - 0.41 11.1 4.3 1.5 9.2 4.3 2.0 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal TPR_4 PF07721.14 CCF32011.1 - 0.79 10.5 4.7 5.3 8.0 0.0 4.2 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 CCF32011.1 - 4.7 8.0 11.2 17 6.2 0.2 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.17 CCF32011.1 - 7.8 6.9 11.8 9.5 6.6 0.1 4.8 6 0 0 6 6 5 0 Tetratricopeptide repeat Cutinase PF01083.22 CCF32012.1 - 2.2e-41 141.8 0.0 3e-41 141.3 0.0 1.2 1 0 0 1 1 1 1 Cutinase DUF2974 PF11187.8 CCF32012.1 - 0.0034 17.0 0.0 0.0055 16.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2974) PE-PPE PF08237.11 CCF32012.1 - 0.0046 16.5 0.1 0.0077 15.8 0.1 1.3 1 0 0 1 1 1 1 PE-PPE domain Lipase_3 PF01764.25 CCF32012.1 - 0.017 15.0 0.0 0.027 14.3 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) Abhydrolase_8 PF06259.12 CCF32012.1 - 0.022 14.4 0.2 0.049 13.3 0.2 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase Palm_thioest PF02089.15 CCF32012.1 - 0.031 14.1 0.1 0.04 13.8 0.1 1.2 1 0 0 1 1 1 0 Palmitoyl protein thioesterase VirJ PF06057.11 CCF32012.1 - 0.066 13.1 0.0 0.098 12.5 0.0 1.2 1 0 0 1 1 1 0 Bacterial virulence protein (VirJ) Cnl2_NKP2 PF09447.10 CCF32014.1 - 3.3e-25 88.0 0.4 7.8e-25 86.8 0.4 1.7 1 0 0 1 1 1 1 Cnl2/NKP2 family protein Tektin PF03148.14 CCF32014.1 - 0.0022 16.8 3.5 0.0026 16.6 3.5 1.1 1 0 0 1 1 1 1 Tektin family DASH_Spc19 PF08287.11 CCF32014.1 - 0.0038 17.1 6.5 0.0038 17.1 0.4 2.2 1 1 1 2 2 2 1 Spc19 Snf7 PF03357.21 CCF32014.1 - 0.0076 15.9 0.2 0.52 9.9 0.1 2.2 2 0 0 2 2 2 1 Snf7 BORCS6 PF10157.9 CCF32014.1 - 0.022 15.0 0.4 0.035 14.3 0.3 1.4 1 1 0 1 1 1 0 BLOC-1-related complex sub-unit 6 Prefoldin_2 PF01920.20 CCF32014.1 - 0.024 14.6 1.8 0.038 13.9 0.4 1.9 2 0 0 2 2 2 0 Prefoldin subunit TMCO5 PF14992.6 CCF32014.1 - 0.03 13.9 3.6 0.042 13.4 1.7 1.9 1 1 1 2 2 2 0 TMCO5 family HAUS-augmin3 PF14932.6 CCF32014.1 - 0.044 13.4 0.6 0.044 13.4 0.6 1.6 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 DivIC PF04977.15 CCF32014.1 - 0.2 11.4 4.3 1.4 8.7 0.1 2.3 2 0 0 2 2 2 0 Septum formation initiator DUF5082 PF16888.5 CCF32014.1 - 0.24 11.7 2.9 0.27 11.5 0.4 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) SlyX PF04102.12 CCF32014.1 - 0.48 11.1 3.9 1.9 9.1 0.1 2.5 2 1 0 2 2 2 0 SlyX Osmo_CC PF08946.10 CCF32014.1 - 0.65 10.3 3.7 1.8 8.9 0.2 2.6 2 1 1 3 3 3 0 Osmosensory transporter coiled coil APG6_N PF17675.1 CCF32014.1 - 0.85 10.2 5.9 1.9 9.0 5.9 1.7 1 1 0 1 1 1 0 Apg6 coiled-coil region Tudor-knot PF11717.8 CCF32016.1 - 3e-09 36.6 0.2 5.1e-09 35.9 0.2 1.4 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Chromo PF00385.24 CCF32016.1 - 0.0044 16.9 0.4 0.0067 16.3 0.4 1.3 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain MRG PF05712.13 CCF32017.1 - 2.3e-56 190.3 0.3 2.6e-56 190.1 0.3 1.0 1 0 0 1 1 1 1 MRG Ribosomal_L30 PF00327.20 CCF32018.1 - 7.6e-16 57.7 0.1 1e-15 57.3 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e CN_hydrolase PF00795.22 CCF32019.1 - 3.3e-18 66.0 0.0 6.6e-17 61.7 0.0 2.0 1 1 1 2 2 2 2 Carbon-nitrogen hydrolase Fungal_trans PF04082.18 CCF32020.1 - 2.3e-36 125.2 0.0 4.5e-36 124.3 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF32021.1 - 2.2e-10 40.5 12.9 4.1e-10 39.6 12.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Clusterin PF01093.17 CCF32021.1 - 0.012 14.7 5.8 0.02 14.0 5.8 1.3 1 0 0 1 1 1 0 Clusterin Crystall_2 PF09076.10 CCF32022.1 - 0.021 14.7 0.1 0.086 12.7 0.1 2.1 2 0 0 2 2 2 0 Beta/Gamma crystallin Kinesin PF00225.23 CCF32025.1 - 3.6e-105 351.6 1.7 7.5e-105 350.5 1.7 1.5 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 CCF32025.1 - 5.7e-56 188.6 0.1 1.7e-55 187.0 0.1 1.9 1 0 0 1 1 1 1 Microtubule binding TRCF PF03461.15 CCF32025.1 - 0.012 16.0 3.6 0.015 15.7 0.4 2.6 1 1 1 2 2 2 0 TRCF domain Uso1_p115_C PF04871.13 CCF32025.1 - 0.017 15.5 14.4 0.017 15.5 14.4 4.9 4 1 2 6 6 5 0 Uso1 / p115 like vesicle tethering protein, C terminal region WEMBL PF05701.11 CCF32025.1 - 0.03 13.0 35.8 0.84 8.3 35.9 2.5 1 1 1 2 2 2 0 Weak chloroplast movement under blue light AAA_16 PF13191.6 CCF32025.1 - 0.18 12.2 0.0 0.18 12.2 0.0 2.6 2 1 0 2 2 1 0 AAA ATPase domain AAA_22 PF13401.6 CCF32025.1 - 0.52 10.6 2.7 0.68 10.2 0.1 2.5 2 0 0 2 2 2 0 AAA domain bZIP_1 PF00170.21 CCF32025.1 - 0.66 10.1 18.7 0.63 10.2 2.5 4.7 3 1 1 4 4 4 0 bZIP transcription factor GIT_CC PF16559.5 CCF32025.1 - 0.68 9.8 9.2 3.9 7.4 0.4 4.4 4 1 1 5 5 5 0 GIT coiled-coil Rho guanine nucleotide exchange factor Spc42p PF11544.8 CCF32025.1 - 0.87 9.6 10.9 0.18 11.9 1.3 3.6 3 0 0 3 3 3 0 Spindle pole body component Spc42p DUF4988 PF16378.5 CCF32025.1 - 0.87 9.2 4.3 16 5.1 0.1 3.6 3 1 0 3 3 3 0 Domain of unknown function HALZ PF02183.18 CCF32025.1 - 6.1 7.2 11.2 0.33 11.2 1.5 3.6 4 0 0 4 4 3 0 Homeobox associated leucine zipper DUF1993 PF09351.10 CCF32025.1 - 9.8 6.3 7.1 3.1 7.9 0.7 2.8 1 1 2 3 3 3 0 Domain of unknown function (DUF1993) IMS PF00817.20 CCF32028.1 - 8.7e-16 58.3 0.0 9.4e-16 58.1 0.0 1.0 1 0 0 1 1 1 1 impB/mucB/samB family CUE PF02845.16 CCF32028.1 - 0.0097 15.6 0.9 0.34 10.7 0.0 2.7 3 0 0 3 3 3 1 CUE domain Carb_anhydrase PF00194.21 CCF32029.1 - 1.5e-13 50.9 0.0 1.9e-13 50.5 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase adh_short PF00106.25 CCF32030.1 - 9.5e-07 28.5 0.0 3.8e-06 26.5 0.0 1.8 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF32030.1 - 0.0007 19.2 0.0 0.00099 18.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF32030.1 - 0.0033 17.3 0.0 0.005 16.8 0.0 1.2 1 0 0 1 1 1 1 KR domain Glyco_hydro_18 PF00704.28 CCF32032.1 - 0.0039 17.0 0.0 0.0048 16.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 LysM PF01476.20 CCF32032.1 - 0.041 14.0 0.0 0.77 9.9 0.0 2.4 2 0 0 2 2 2 0 LysM domain APH PF01636.23 CCF32033.1 - 9.8e-10 38.7 0.0 4.9e-09 36.5 0.0 1.9 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CCF32033.1 - 1.2e-05 25.0 0.0 1.8e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase DUF1679 PF07914.11 CCF32033.1 - 0.0018 17.2 0.0 0.0025 16.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) RIO1 PF01163.22 CCF32033.1 - 0.027 14.1 0.0 7.5 6.1 0.0 2.1 2 0 0 2 2 2 0 RIO1 family Fructosamin_kin PF03881.14 CCF32033.1 - 0.12 11.6 0.0 3.5 6.7 0.0 2.2 1 1 0 2 2 2 0 Fructosamine kinase DZR PF12773.7 CCF32033.1 - 0.12 12.4 1.4 0.26 11.3 1.4 1.5 1 0 0 1 1 1 0 Double zinc ribbon AzlC PF03591.14 CCF32036.1 - 0.028 14.9 3.2 0.028 14.9 3.2 3.2 3 1 1 4 4 4 0 AzlC protein SIR2 PF02146.17 CCF32037.1 - 7.9e-23 81.3 0.0 9.8e-23 81.0 0.0 1.1 1 0 0 1 1 1 1 Sir2 family Peptidase_S8 PF00082.22 CCF32041.1 - 4.3e-42 144.4 0.9 6.4e-42 143.8 0.9 1.2 1 0 0 1 1 1 1 Subtilase family fn3_5 PF06280.12 CCF32041.1 - 4.8e-09 36.9 0.2 4.7e-08 33.7 0.0 2.5 3 0 0 3 3 3 1 Fn3-like domain SPC12 PF06645.13 CCF32041.1 - 0.075 13.1 0.1 0.2 11.8 0.1 1.7 1 0 0 1 1 1 0 Microsomal signal peptidase 12 kDa subunit (SPC12) Opi1 PF08618.10 CCF32042.1 - 2.6e-37 129.1 7.0 8.4e-31 107.6 2.2 5.3 4 1 1 5 5 5 3 Transcription factor Opi1 AA_permease_N PF08403.10 CCF32042.1 - 0.027 14.0 0.3 0.064 12.8 0.3 1.6 1 0 0 1 1 1 0 Amino acid permease N-terminal Ribosomal_S7 PF00177.21 CCF32043.1 - 8.2e-38 129.4 1.4 1e-37 129.1 1.4 1.1 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e Acetyltransf_1 PF00583.25 CCF32044.1 - 4.8e-05 23.6 0.1 0.00066 19.9 0.1 2.6 2 1 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CCF32044.1 - 0.0023 17.9 0.0 2.7 8.0 0.0 2.4 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_5 PF13444.6 CCF32044.1 - 0.0047 17.6 0.0 1.4 9.7 0.0 3.1 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CCF32044.1 - 0.023 15.1 0.1 0.084 13.3 0.1 2.0 2 1 0 2 2 2 0 Acetyltransferase (GNAT) domain HMA PF00403.26 CCF32045.1 - 3.5e-16 59.4 0.5 3.5e-16 59.4 0.5 1.6 2 0 0 2 2 2 1 Heavy-metal-associated domain Tcf25 PF04910.14 CCF32046.1 - 2.3e-61 207.8 0.1 4.2e-61 207.0 0.1 1.4 1 0 0 1 1 1 1 Transcriptional repressor TCF25 NIF PF03031.18 CCF32047.1 - 2.9e-55 186.3 0.0 4e-55 185.9 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase IF-2B PF01008.17 CCF32048.1 - 2e-39 135.5 0.0 7.4e-39 133.7 0.0 1.8 1 1 0 1 1 1 1 Initiation factor 2 subunit family EST1_DNA_bind PF10373.9 CCF32050.1 - 1.2e-12 47.9 0.0 8.3e-12 45.2 0.0 2.1 1 1 0 1 1 1 1 Est1 DNA/RNA binding domain Ribosomal_L27A PF00828.19 CCF32051.1 - 2.3e-08 34.8 5.9 3.6e-08 34.1 5.9 1.3 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A RPS31 PF17067.5 CCF32051.1 - 0.13 12.5 2.0 0.16 12.1 2.0 1.1 1 0 0 1 1 1 0 Ribosomal protein S31e PX PF00787.24 CCF32052.1 - 2e-17 63.2 0.1 3.7e-17 62.3 0.1 1.4 1 0 0 1 1 1 1 PX domain Methylase_S PF01420.19 CCF32052.1 - 0.058 13.6 0.0 0.097 12.9 0.0 1.2 1 0 0 1 1 1 0 Type I restriction modification DNA specificity domain Drf_GBD PF06371.13 CCF32055.1 - 4.4e-65 218.8 0.3 1.2e-64 217.4 0.0 1.9 2 0 0 2 2 2 1 Diaphanous GTPase-binding Domain Drf_FH3 PF06367.16 CCF32055.1 - 3.8e-52 176.8 2.9 1.6e-51 174.7 2.3 2.2 1 1 1 2 2 2 1 Diaphanous FH3 Domain Rx_N PF18052.1 CCF32055.1 - 2.2 8.6 8.9 0.78 10.0 3.7 2.8 2 0 0 2 2 2 0 Rx N-terminal domain Bap31_Bap29_C PF18035.1 CCF32055.1 - 2.9 8.0 5.6 10 6.2 5.6 1.9 1 0 0 1 1 1 0 Bap31/Bap29 cytoplasmic coiled-coil domain CAP_N PF01213.19 CCF32055.1 - 7.1 6.0 6.5 18 4.7 6.5 1.6 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal zf-RING_2 PF13639.6 CCF32058.1 - 7.9e-08 32.5 6.0 7.9e-08 32.5 6.0 2.8 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4 PF00097.25 CCF32058.1 - 5.2e-06 26.2 0.5 5.2e-06 26.2 0.5 2.5 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 CCF32058.1 - 0.0001 22.5 5.7 0.0001 22.5 5.7 2.4 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 CCF32058.1 - 0.00016 21.7 0.1 0.00016 21.7 0.1 2.8 2 1 1 3 3 3 1 RING-type zinc-finger zf-RING_11 PF17123.5 CCF32058.1 - 0.00035 20.3 4.4 0.00039 20.1 0.0 2.8 3 1 0 3 3 3 1 RING-like zinc finger zf-ANAPC11 PF12861.7 CCF32058.1 - 0.0024 17.9 4.5 0.0024 17.9 4.5 1.9 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.6 CCF32058.1 - 0.0025 17.6 4.8 0.0025 17.6 4.8 3.4 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CCF32058.1 - 0.0029 17.5 7.3 0.0073 16.2 2.8 2.5 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 CCF32058.1 - 0.062 13.5 0.2 0.062 13.5 0.2 3.1 4 0 0 4 4 4 0 zinc finger of C3HC4-type, RING NDUF_B12 PF08122.12 CCF32058.1 - 0.15 12.1 5.6 1 9.5 2.2 2.8 3 0 0 3 3 3 0 NADH-ubiquinone oxidoreductase B12 subunit family RRM_1 PF00076.22 CCF32059.1 - 1.1e-11 44.3 0.1 7.2e-10 38.5 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FAD_binding_1 PF00667.20 CCF32060.1 - 4.2e-61 206.4 0.0 6.3e-61 205.8 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 CCF32060.1 - 2.1e-32 112.3 0.7 4.5e-32 111.2 0.7 1.6 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 CCF32060.1 - 1.9e-20 73.5 0.0 1e-19 71.2 0.0 2.0 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Flavodoxin_5 PF12724.7 CCF32060.1 - 0.053 13.8 0.1 0.22 11.8 0.0 2.1 2 0 0 2 2 2 0 Flavodoxin domain Pkinase PF00069.25 CCF32061.1 - 5.5e-64 216.1 0.0 1.1e-63 215.0 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF32061.1 - 5.7e-36 124.1 0.0 3.5e-30 105.2 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 CCF32061.1 - 3e-07 30.1 0.0 3.3e-05 23.3 0.0 2.2 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 CCF32061.1 - 0.00027 20.9 0.0 0.00056 19.9 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 CCF32061.1 - 0.019 14.0 0.1 0.033 13.2 0.1 1.3 1 0 0 1 1 1 0 Haspin like kinase domain RIO1 PF01163.22 CCF32061.1 - 0.024 14.2 0.0 0.046 13.3 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Kdo PF06293.14 CCF32061.1 - 0.034 13.5 0.0 0.06 12.7 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 CCF32061.1 - 0.12 11.1 0.0 0.4 9.4 0.0 1.8 1 0 0 1 1 1 0 Fungal protein kinase Sel1 PF08238.12 CCF32062.1 - 9.8e-47 156.4 21.9 9.6e-09 35.6 0.1 8.2 7 0 0 7 7 7 7 Sel1 repeat TPR_20 PF14561.6 CCF32062.1 - 0.06 13.7 0.2 0.18 12.2 0.2 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat HD_2 PF12917.7 CCF32062.1 - 0.063 13.0 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 HD containing hydrolase-like enzyme CHASE3 PF05227.13 CCF32062.1 - 0.48 10.3 1.8 2.5 8.0 0.7 2.2 2 0 0 2 2 2 0 CHASE3 domain PfkB PF00294.24 CCF32063.1 - 6.6e-54 183.3 0.8 7.6e-54 183.0 0.8 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase DDDD PF10161.9 CCF32065.1 - 0.008 15.9 1.1 0.95 9.3 0.0 2.3 1 1 1 2 2 2 2 Putative mitochondrial precursor protein UQ_con PF00179.26 CCF32066.1 - 3.3e-10 39.7 0.0 5.1e-10 39.1 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Ccdc124 PF06244.12 CCF32067.1 - 9.9e-29 100.5 17.9 9.9e-29 100.5 17.9 2.5 2 1 0 2 2 2 1 Coiled-coil domain-containing protein 124 /Oxs1 DUF2894 PF11445.8 CCF32067.1 - 0.82 10.1 13.4 0.23 11.9 4.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2894) A_amylase_inhib PF01356.19 CCF32068.1 - 0.02 14.9 0.2 0.87 9.6 0.0 2.5 2 1 0 2 2 2 0 Alpha amylase inhibitor adh_short PF00106.25 CCF32069.1 - 7.6e-23 81.0 0.0 6.3e-18 64.9 0.0 2.1 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCF32069.1 - 2.9e-16 59.8 0.0 1.2e-11 44.6 0.0 2.1 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF32069.1 - 8.4e-06 25.8 0.1 1.6e-05 24.9 0.1 1.7 1 1 0 1 1 1 1 KR domain Pkinase PF00069.25 CCF32070.1 - 9.9e-31 107.1 0.0 4.6e-30 104.9 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF32070.1 - 0.00024 20.5 0.0 0.025 13.9 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 CCF32070.1 - 0.018 13.8 0.6 0.042 12.6 0.2 1.5 1 1 0 2 2 2 0 Fungal protein kinase adh_short PF00106.25 CCF32071.1 - 3.4e-24 85.4 0.0 3.3e-23 82.2 0.0 2.0 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF32071.1 - 1.1e-14 54.5 0.0 6.5e-14 52.1 0.0 1.8 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF32071.1 - 5.9e-05 23.1 0.0 0.00011 22.2 0.0 1.5 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF32071.1 - 0.00013 21.5 0.0 0.0002 20.9 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CCF32071.1 - 0.17 11.2 0.0 0.71 9.2 0.0 1.7 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase AdoHcyase_NAD PF00670.21 CCF32071.1 - 0.2 11.7 0.3 0.33 11.0 0.3 1.2 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain NAD_kinase PF01513.21 CCF32073.1 - 2.7e-72 243.5 0.0 5.7e-72 242.4 0.0 1.5 1 1 0 1 1 1 1 ATP-NAD kinase DUF3402 PF11882.8 CCF32074.1 - 7.1e-214 711.1 0.0 9.4e-214 710.7 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3402) N1221 PF07923.13 CCF32074.1 - 1.2e-91 306.9 0.1 2.4e-91 305.9 0.1 1.5 1 0 0 1 1 1 1 N1221-like protein MARVEL PF01284.23 CCF32075.1 - 0.00043 20.3 17.6 0.0033 17.5 17.9 1.9 1 1 0 1 1 1 1 Membrane-associating domain DUF3422 PF11902.8 CCF32075.1 - 0.017 14.2 0.8 2.2 7.3 0.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3422) Rhabdo_glycop PF00974.18 CCF32075.1 - 0.18 10.2 0.4 5.9 5.2 0.1 2.1 2 0 0 2 2 2 0 Rhabdovirus spike glycoprotein DUF4233 PF14017.6 CCF32075.1 - 0.61 10.5 8.8 0.31 11.4 5.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4233) GRP PF07172.11 CCF32075.1 - 3.3 8.5 9.2 92 3.8 0.0 2.6 2 1 1 3 3 3 0 Glycine rich protein family Reticulon PF02453.17 CCF32075.1 - 8 6.4 8.1 0.83 9.6 0.8 2.5 3 0 0 3 3 3 0 Reticulon WSC PF01822.19 CCF32076.1 - 4.2e-72 238.4 70.3 1.5e-18 66.8 11.0 5.0 4 0 0 4 4 4 4 WSC domain peroxidase PF00141.23 CCF32076.1 - 2.7e-20 73.1 0.1 5.5e-20 72.0 0.1 1.4 1 0 0 1 1 1 1 Peroxidase Sec7 PF01369.20 CCF32077.1 - 1.2e-28 100.0 0.6 2e-28 99.3 0.1 1.5 2 0 0 2 2 2 1 Sec7 domain PH_9 PF15410.6 CCF32077.1 - 2.9e-16 59.9 0.0 6.8e-16 58.7 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PRKCSH PF07915.13 CCF32078.1 - 9.1e-19 68.3 0.2 9.1e-19 68.3 0.2 2.0 2 0 0 2 2 2 1 Glucosidase II beta subunit-like protein PRKCSH_1 PF13015.6 CCF32078.1 - 0.03 14.0 0.0 2.5 7.8 0.0 2.3 2 0 0 2 2 2 0 Glucosidase II beta subunit-like protein SPATA9 PF15824.5 CCF32079.1 - 0.057 12.7 0.0 0.077 12.3 0.0 1.2 1 0 0 1 1 1 0 Spermatogenesis-associated protein 9 ArfGap PF01412.18 CCF32080.1 - 1.2e-32 112.4 0.5 5.2e-32 110.4 0.0 2.4 3 0 0 3 3 3 1 Putative GTPase activating protein for Arf BAR_3 PF16746.5 CCF32080.1 - 1.8e-17 63.8 14.6 2.7e-17 63.3 14.6 1.2 1 0 0 1 1 1 1 BAR domain of APPL family PH PF00169.29 CCF32080.1 - 3.2e-13 50.1 0.3 9.6e-13 48.6 0.3 1.9 1 0 0 1 1 1 1 PH domain tRNA-synt_2 PF00152.20 CCF32080.1 - 0.087 11.9 8.1 0.15 11.1 8.1 1.4 1 0 0 1 1 1 0 tRNA synthetases class II (D, K and N) EMP24_GP25L PF01105.24 CCF32080.1 - 0.16 11.9 2.4 0.38 10.7 2.4 1.6 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD PH_9 PF15410.6 CCF32080.1 - 0.18 12.2 4.9 0.53 10.7 1.1 3.2 2 1 0 2 2 2 0 Pleckstrin homology domain ANAPC9 PF12856.7 CCF32080.1 - 0.39 10.9 5.1 0.98 9.6 5.1 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 9 BAR PF03114.18 CCF32080.1 - 3.1 7.4 13.5 0.28 10.8 8.3 1.9 1 1 0 1 1 1 0 BAR domain Pkinase PF00069.25 CCF32081.1 - 3e-77 259.6 0.0 4.2e-77 259.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF32081.1 - 7.3e-38 130.3 0.0 9.9e-38 129.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 CCF32081.1 - 2.3e-18 66.3 0.2 5.1e-18 65.2 0.2 1.6 1 0 0 1 1 1 1 FHA domain Kinase-like PF14531.6 CCF32081.1 - 2.6e-10 40.1 0.0 1.8e-08 34.0 0.0 2.6 3 0 0 3 3 3 1 Kinase-like Yop-YscD_cpl PF16697.5 CCF32081.1 - 2.3e-09 37.5 0.0 5.2e-09 36.3 0.0 1.5 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Pkinase_fungal PF17667.1 CCF32081.1 - 4e-07 29.2 0.0 5.8e-07 28.6 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 CCF32081.1 - 3e-05 23.5 0.1 0.0003 20.2 0.1 2.2 2 1 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 CCF32081.1 - 0.0021 17.7 0.4 0.98 9.0 0.0 2.3 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 YrbL-PhoP_reg PF10707.9 CCF32081.1 - 0.038 13.5 0.0 0.093 12.2 0.0 1.6 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Pox_ser-thr_kin PF05445.11 CCF32081.1 - 0.07 12.1 0.1 0.12 11.3 0.1 1.3 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase DnaJ PF00226.31 CCF32082.1 - 1.5e-20 73.1 1.7 3.9e-20 71.7 1.7 1.8 1 0 0 1 1 1 1 DnaJ domain MFS_1 PF07690.16 CCF32084.1 - 1.1e-06 27.8 8.6 1.2e-06 27.7 8.6 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF32084.1 - 0.053 12.4 3.0 0.058 12.2 3.0 1.0 1 0 0 1 1 1 0 Sugar (and other) transporter DUF4212 PF13937.6 CCF32084.1 - 0.09 13.2 3.0 0.11 12.9 3.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4212) UPF0139 PF03669.13 CCF32084.1 - 0.22 11.4 0.2 0.25 11.2 0.2 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0139) Ferritin_2 PF13668.6 CCF32086.1 - 2.6e-05 24.5 0.0 4.1e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Ferritin-like domain MaoC_dehydratas PF01575.19 CCF32092.1 - 9.8e-21 73.6 0.0 1.7e-20 72.8 0.0 1.3 1 0 0 1 1 1 1 MaoC like domain MaoC_dehydrat_N PF13452.6 CCF32092.1 - 3e-05 24.1 0.0 0.00047 20.3 0.0 2.3 2 1 0 2 2 2 1 N-terminal half of MaoC dehydratase ERp29_N PF07912.13 CCF32092.1 - 0.013 15.7 0.0 0.022 14.9 0.0 1.3 1 0 0 1 1 1 0 ERp29, N-terminal domain CAP_GLY PF01302.25 CCF32093.1 - 1.1e-19 70.2 0.1 1.7e-19 69.6 0.1 1.3 1 0 0 1 1 1 1 CAP-Gly domain Gly_transf_sug PF04488.15 CCF32095.1 - 7.6e-13 48.9 0.1 1.4e-12 48.1 0.1 1.3 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Caps_synth PF05704.12 CCF32095.1 - 0.0025 17.2 0.1 0.0046 16.4 0.1 1.4 1 0 0 1 1 1 1 Capsular polysaccharide synthesis protein TcdA_TcdB PF12919.7 CCF32095.1 - 0.16 11.2 0.1 0.26 10.6 0.1 1.2 1 0 0 1 1 1 0 TcdA/TcdB catalytic glycosyltransferase domain Transp_cyt_pur PF02133.15 CCF32096.1 - 5.3e-57 193.5 12.0 6.6e-57 193.2 12.0 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin ketoacyl-synt PF00109.26 CCF32097.1 - 3.8e-44 151.2 0.0 4.9e-44 150.8 0.0 1.1 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain MFS_1 PF07690.16 CCF32098.1 - 1e-25 90.5 53.7 3.8e-24 85.3 50.6 3.5 2 1 0 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 CCF32098.1 - 1.6e-09 36.7 8.1 2.7e-09 36.0 8.1 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) TauD PF02668.16 CCF32099.1 - 1.2e-36 126.9 1.3 1.4e-36 126.7 1.3 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family FSH1 PF03959.13 CCF32100.1 - 3.3e-29 102.1 0.0 4e-29 101.8 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.16 CCF32100.1 - 8e-06 25.8 0.0 2.4e-05 24.2 0.0 1.8 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_6 PF12697.7 CCF32100.1 - 0.00086 20.0 0.1 0.0099 16.5 0.0 1.8 1 1 1 2 2 2 1 Alpha/beta hydrolase family UDPGT PF00201.18 CCF32101.1 - 0.011 14.5 0.0 0.041 12.7 0.0 1.8 2 0 0 2 2 2 0 UDP-glucoronosyl and UDP-glucosyl transferase Sugar_tr PF00083.24 CCF32102.1 - 9.3e-116 387.3 25.8 1.1e-115 387.1 25.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF32102.1 - 5.5e-25 88.0 26.0 5.4e-23 81.5 22.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily CN_hydrolase PF00795.22 CCF32103.1 - 1.5e-44 152.4 0.0 1.8e-44 152.0 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase CIA30 PF08547.12 CCF32104.1 - 3.3e-36 124.7 0.0 4e-36 124.5 0.0 1.0 1 0 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) DUF3328 PF11807.8 CCF32105.1 - 1.4e-26 93.6 6.2 1.7e-26 93.4 6.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) DUF346 PF03984.13 CCF32105.1 - 0.044 13.5 0.2 0.11 12.3 0.2 1.6 1 0 0 1 1 1 0 Repeat of unknown function (DUF346) MFS_1 PF07690.16 CCF32106.1 - 1e-13 51.0 10.5 2.1e-10 40.1 11.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 CCF32106.1 - 7.1e-06 24.7 7.2 8.7e-06 24.4 7.2 1.0 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Ribonuc_P_40 PF08584.11 CCF32107.1 - 2.9e-55 187.6 0.0 3.9e-55 187.1 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease P 40kDa (Rpp40) subunit Ank_5 PF13857.6 CCF32108.1 - 2.2e-08 34.2 0.1 8.8e-07 29.1 0.1 2.4 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 CCF32108.1 - 1.8e-06 28.4 0.0 0.00017 22.1 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 CCF32108.1 - 8.4e-06 26.3 0.7 1.8e-05 25.2 0.3 1.7 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CCF32108.1 - 1.3e-05 25.2 0.7 0.0016 18.8 0.1 3.0 3 0 0 3 3 3 1 Ankyrin repeat Ank PF00023.30 CCF32108.1 - 0.0025 18.2 0.1 0.11 12.9 0.1 2.6 2 0 0 2 2 2 1 Ankyrin repeat tRNA_lig_CPD PF08302.11 CCF32109.1 - 2.1e-90 302.6 0.0 2.9e-90 302.2 0.0 1.2 1 0 0 1 1 1 1 Fungal tRNA ligase phosphodiesterase domain RNA_lig_T4_1 PF09511.10 CCF32109.1 - 1.8e-84 283.0 0.0 3.9e-84 281.9 0.0 1.6 1 0 0 1 1 1 1 RNA ligase tRNA_lig_kinase PF08303.11 CCF32109.1 - 6.8e-53 179.2 0.0 1.6e-52 178.0 0.0 1.6 1 0 0 1 1 1 1 tRNA ligase kinase domain AAA_18 PF13238.6 CCF32109.1 - 0.065 13.8 0.1 0.31 11.6 0.0 2.3 2 1 0 2 2 2 0 AAA domain Ish1 PF10281.9 CCF32110.1 - 6.8e-84 275.9 25.8 9.7e-14 51.4 0.1 8.5 8 0 0 8 8 8 8 Putative stress-responsive nuclear envelope protein SAP PF02037.27 CCF32110.1 - 2.2e-09 36.9 0.0 6.1 6.7 0.0 7.6 8 1 0 8 8 8 3 SAP domain HeH PF12949.7 CCF32110.1 - 2e-05 24.2 0.0 1.7 8.4 0.0 5.7 6 0 0 6 6 6 1 HeH/LEM domain Slx4 PF09494.10 CCF32110.1 - 0.00029 20.7 0.3 56 3.8 0.0 6.0 7 0 0 7 7 7 0 Slx4 endonuclease SAM_2 PF07647.17 CCF32110.1 - 0.04 14.0 1.3 1.7 8.8 0.1 3.7 4 0 0 4 4 4 0 SAM domain (Sterile alpha motif) Thymopoietin PF08198.11 CCF32110.1 - 0.098 12.3 0.0 17 5.1 0.0 3.8 3 0 0 3 3 3 0 Thymopoietin protein TubC_N PF18563.1 CCF32110.1 - 0.11 12.5 0.1 2.5 8.1 0.0 2.7 2 0 0 2 2 2 0 TubC N-terminal docking domain Hydrophobin_2 PF06766.11 CCF32111.1 - 3.1e-26 91.1 9.6 3.8e-26 90.8 9.6 1.1 1 0 0 1 1 1 1 Fungal hydrophobin Tryp_inh PF17983.1 CCF32111.1 - 1.4 9.0 8.1 11 6.2 1.2 2.5 2 0 0 2 2 2 0 Trypsin inhibitors 1,2 and 3 AAA PF00004.29 CCF32112.1 - 9.6e-40 136.1 0.0 1.9e-39 135.1 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 CCF32112.1 - 1.2e-18 66.7 0.1 2.4e-18 65.8 0.1 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 CCF32112.1 - 6e-07 29.2 0.0 1.2e-06 28.2 0.0 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 CCF32112.1 - 0.00012 22.5 1.7 0.02 15.3 0.0 2.9 2 1 1 3 3 3 1 AAA ATPase domain AAA_5 PF07728.14 CCF32112.1 - 0.00018 21.5 1.7 0.00071 19.6 0.1 2.6 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 CCF32112.1 - 0.00036 20.3 0.0 0.00091 19.0 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 CCF32112.1 - 0.001 19.4 1.3 0.082 13.2 0.0 3.0 2 1 1 3 3 3 1 AAA domain AAA_2 PF07724.14 CCF32112.1 - 0.0019 18.3 0.4 0.011 15.9 0.0 2.3 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) PhoH PF02562.16 CCF32112.1 - 0.0056 16.2 0.2 0.08 12.4 0.1 2.3 2 0 0 2 2 2 1 PhoH-like protein Mg_chelatase PF01078.21 CCF32112.1 - 0.0084 15.5 0.0 0.02 14.3 0.0 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI DUF815 PF05673.13 CCF32112.1 - 0.012 14.7 0.0 0.027 13.7 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_33 PF13671.6 CCF32112.1 - 0.015 15.5 0.0 0.034 14.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 CCF32112.1 - 0.072 12.8 0.1 0.18 11.5 0.1 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_7 PF12775.7 CCF32112.1 - 0.12 11.9 0.0 0.31 10.5 0.0 1.7 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_11 PF13086.6 CCF32112.1 - 0.6 9.8 0.0 0.6 9.8 0.0 2.5 2 1 0 2 2 2 0 AAA domain RPN2_C PF18004.1 CCF32112.1 - 0.61 10.0 5.6 1.4 8.8 5.6 1.5 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain hDGE_amylase PF14701.6 CCF32113.1 - 1.2e-178 594.7 0.0 1.6e-178 594.4 0.0 1.1 1 0 0 1 1 1 1 Glycogen debranching enzyme, glucanotransferase domain GDE_C PF06202.14 CCF32113.1 - 9.9e-115 383.5 0.0 2e-114 382.5 0.0 1.5 2 0 0 2 2 2 1 Amylo-alpha-1,6-glucosidase hGDE_central PF14702.6 CCF32113.1 - 2.7e-89 299.2 0.0 2e-88 296.3 0.0 2.3 2 0 0 2 2 2 1 Central domain of human glycogen debranching enzyme hGDE_N PF14699.6 CCF32113.1 - 1.3e-29 102.2 0.0 2.8e-29 101.1 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain from the human glycogen debranching enzyme DUF4381 PF14316.6 CCF32114.1 - 0.026 14.8 0.6 0.04 14.1 0.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) DUF4231 PF14015.6 CCF32114.1 - 0.071 13.6 0.2 0.12 12.9 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4231) UL42 PF17638.2 CCF32114.1 - 0.1 12.6 2.1 0.17 11.8 0.1 2.1 2 0 0 2 2 2 0 HCMV UL42 UPF0370 PF13980.6 CCF32114.1 - 0.15 12.1 3.2 0.23 11.5 3.2 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0370) Cu-oxidase_2 PF07731.14 CCF32115.1 - 2.2e-26 92.2 10.0 1.3e-24 86.5 2.7 3.0 3 0 0 3 3 3 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 CCF32115.1 - 3.7e-18 65.6 2.3 7.2e-18 64.7 0.1 2.6 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase PF00394.22 CCF32115.1 - 3.4e-06 27.3 0.1 7.5e-05 22.9 0.0 3.0 4 0 0 4 4 4 1 Multicopper oxidase TFB6 PF17110.5 CCF32115.1 - 0.043 13.6 0.1 0.071 12.9 0.1 1.2 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Keratin_2_head PF16208.5 CCF32116.1 - 0.18 11.9 17.2 0.033 14.3 7.8 2.5 2 0 0 2 2 2 0 Keratin type II head F-box-like PF12937.7 CCF32117.1 - 0.00029 20.7 0.4 0.00098 19.0 0.4 2.0 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCF32117.1 - 0.011 15.5 0.2 0.064 13.2 0.2 2.4 1 0 0 1 1 1 0 F-box domain DUF4471 PF14740.6 CCF32118.1 - 0.53 9.5 10.8 2.4 7.3 2.6 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4471) AAA_23 PF13476.6 CCF32118.1 - 5.3 7.5 17.1 7.3 7.0 4.7 2.4 2 0 0 2 2 2 0 AAA domain Peroxin-13_N PF04088.13 CCF32118.1 - 7.2 6.9 6.5 24 5.2 0.7 2.8 2 0 0 2 2 2 0 Peroxin 13, N-terminal region FHIPEP PF00771.20 CCF32118.1 - 8 4.8 4.7 13 4.0 0.1 2.1 2 0 0 2 2 2 0 FHIPEP family HAP1_N PF04849.13 CCF32119.1 - 0.00094 18.5 2.5 0.0016 17.7 2.5 1.4 1 0 0 1 1 1 1 HAP1 N-terminal conserved region Prefoldin_2 PF01920.20 CCF32119.1 - 0.036 14.0 1.3 0.036 14.0 1.3 2.0 1 1 1 2 2 2 0 Prefoldin subunit Mce4_CUP1 PF11887.8 CCF32119.1 - 0.05 13.1 4.4 0.072 12.5 1.6 2.2 2 0 0 2 2 2 0 Cholesterol uptake porter CUP1 of Mce4, putative Mtr2 PF10429.9 CCF32119.1 - 0.054 13.4 0.5 0.13 12.2 0.5 1.6 1 0 0 1 1 1 0 Nuclear pore RNA shuttling protein Mtr2 RasGAP_C PF03836.15 CCF32119.1 - 0.21 11.7 3.9 19 5.4 0.0 2.4 2 0 0 2 2 2 0 RasGAP C-terminus ZapB PF06005.12 CCF32119.1 - 0.22 12.0 6.9 0.13 12.7 2.3 2.4 1 1 1 2 2 2 0 Cell division protein ZapB Jnk-SapK_ap_N PF09744.9 CCF32119.1 - 0.23 11.7 2.4 0.51 10.6 2.4 1.5 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 DUF5320 PF17253.2 CCF32119.1 - 0.3 12.2 7.9 1.7 9.7 2.2 2.7 1 1 1 2 2 2 0 Family of unknown function (DUF5320) DUF2203 PF09969.9 CCF32119.1 - 2.5 8.9 6.6 1.4 9.7 0.3 2.6 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2203) DUF3450 PF11932.8 CCF32119.1 - 2.7 7.2 17.0 0.032 13.5 9.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) APG6_N PF17675.1 CCF32119.1 - 8.2 7.0 8.9 0.36 11.4 2.8 1.8 2 0 0 2 2 2 0 Apg6 coiled-coil region Flu_M2 PF00599.17 CCF32120.1 - 0.056 13.5 0.0 0.094 12.8 0.0 1.3 1 0 0 1 1 1 0 Influenza Matrix protein (M2) Sun2_CC2 PF18580.1 CCF32120.1 - 0.061 13.6 0.2 0.11 12.7 0.2 1.4 1 0 0 1 1 1 0 SUN2 coiled coil domain 2 DUF3572 PF12096.8 CCF32120.1 - 0.066 13.4 0.1 0.16 12.2 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3572) DUF202 PF02656.15 CCF32120.1 - 0.08 13.4 0.1 0.15 12.5 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF202) Cwf_Cwc_15 PF04889.12 CCF32121.1 - 0.048 13.4 2.8 0.057 13.1 2.8 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Cullin PF00888.22 CCF32122.1 - 2e-190 634.5 11.6 2e-190 634.5 11.6 1.5 2 0 0 2 2 2 1 Cullin family Cullin_Nedd8 PF10557.9 CCF32122.1 - 1.4e-26 92.3 1.4 5.1e-26 90.5 1.4 2.1 1 0 0 1 1 1 1 Cullin protein neddylation domain RGS PF00615.19 CCF32122.1 - 0.006 16.9 0.3 0.02 15.2 0.3 1.9 1 0 0 1 1 1 1 Regulator of G protein signaling domain HEPN_DZIP3 PF18738.1 CCF32122.1 - 0.029 14.1 0.8 1.1 9.0 0.0 2.7 2 0 0 2 2 2 0 DZIP3/ hRUL138-like HEPN Rrf2 PF02082.20 CCF32122.1 - 0.14 12.6 0.0 0.9 9.9 0.0 2.4 1 0 0 1 1 1 0 Transcriptional regulator DUF1041 PF06292.17 CCF32122.1 - 0.23 11.9 1.6 1.4 9.3 0.1 2.7 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1041) DPPIV_N PF00930.21 CCF32123.1 - 1.3e-107 359.6 0.3 2.3e-107 358.8 0.3 1.4 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 CCF32123.1 - 1.1e-53 181.8 2.1 2.5e-53 180.7 2.1 1.6 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 CCF32123.1 - 4.2e-07 29.8 1.9 1.2e-05 25.1 0.4 2.3 1 1 1 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_6 PF12697.7 CCF32123.1 - 0.00012 22.8 3.9 0.035 14.7 0.5 2.9 2 1 1 3 3 3 2 Alpha/beta hydrolase family AXE1 PF05448.12 CCF32123.1 - 0.067 11.9 0.1 1.2 7.7 0.1 2.1 1 1 0 1 1 1 0 Acetyl xylan esterase (AXE1) Osw5 PF17062.5 CCF32123.1 - 0.15 12.1 0.4 0.28 11.3 0.4 1.4 1 0 0 1 1 1 0 Outer spore wall 5 YbjQ_1 PF01906.17 CCF32124.1 - 5.2e-26 91.3 0.1 6.2e-26 91.1 0.1 1.1 1 0 0 1 1 1 1 Putative heavy-metal-binding DUF3328 PF11807.8 CCF32125.1 - 6e-17 62.2 1.0 6.9e-17 62.0 1.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) DUF3328 PF11807.8 CCF32126.1 - 0.0014 18.5 0.0 0.0016 18.3 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) NapE PF06796.11 CCF32126.1 - 0.14 11.7 1.2 0.23 11.0 1.2 1.3 1 0 0 1 1 1 0 Periplasmic nitrate reductase protein NapE DUF2722 PF10846.8 CCF32127.1 - 2e-05 23.7 0.3 2e-05 23.7 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Pex14_N PF04695.13 CCF32127.1 - 0.0012 19.6 0.5 0.0017 19.0 0.5 1.2 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Cadherin_C PF01049.17 CCF32127.1 - 0.0032 17.8 0.6 0.0073 16.7 0.6 1.5 1 0 0 1 1 1 1 Cadherin cytoplasmic region TraE PF05309.11 CCF32127.1 - 0.0093 15.4 0.1 0.014 14.8 0.1 1.2 1 0 0 1 1 1 1 TraE protein TFIIA PF03153.13 CCF32127.1 - 0.012 15.6 6.0 0.016 15.3 6.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Med15 PF09606.10 CCF32127.1 - 0.017 13.9 6.8 0.02 13.6 6.8 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Roughex PF06020.11 CCF32127.1 - 0.018 14.2 0.7 0.024 13.7 0.7 1.2 1 0 0 1 1 1 0 Drosophila roughex protein DUF5345 PF17280.2 CCF32127.1 - 0.022 14.7 3.0 0.042 13.8 3.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5345) Connexin PF00029.19 CCF32127.1 - 0.023 14.5 0.0 0.035 13.9 0.0 1.2 1 0 0 1 1 1 0 Connexin Coiled-coil_56 PF09813.9 CCF32127.1 - 0.028 14.5 1.5 0.052 13.6 1.5 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 56 AXIN1_TNKS_BD PF16646.5 CCF32127.1 - 0.046 14.6 0.7 0.12 13.3 0.7 1.7 1 0 0 1 1 1 0 Axin-1 tankyrase binding domain 7tm_1 PF00001.21 CCF32127.1 - 0.066 12.5 0.2 0.089 12.1 0.2 1.2 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) DUF3525 PF12039.8 CCF32127.1 - 0.15 10.8 0.0 0.2 10.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3525) DUF2391 PF09622.10 CCF32127.1 - 0.21 10.9 0.5 0.29 10.4 0.5 1.2 1 0 0 1 1 1 0 Putative integral membrane protein (DUF2391) Pex26 PF07163.12 CCF32127.1 - 0.37 10.0 3.7 0.57 9.5 3.7 1.2 1 0 0 1 1 1 0 Pex26 protein Spt20 PF12090.8 CCF32127.1 - 1.4 8.5 17.7 2.1 7.9 17.7 1.2 1 0 0 1 1 1 0 Spt20 family DUF5349 PF17298.2 CCF32127.1 - 3 7.5 6.2 5.9 6.6 6.2 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5349) DUF3328 PF11807.8 CCF32128.1 - 6.2e-21 75.2 0.2 1.7e-20 73.8 0.2 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF3328) 2OG-FeII_Oxy_3 PF13640.6 CCF32129.1 - 3.2e-08 34.4 0.0 5.9e-08 33.5 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Abhydrolase_6 PF12697.7 CCF32130.1 - 0.00024 21.8 0.0 0.00027 21.6 0.0 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CCF32130.1 - 0.14 11.7 0.0 0.16 11.6 0.0 1.0 1 0 0 1 1 1 0 alpha/beta hydrolase fold UTP15_C PF09384.10 CCF32131.1 - 2.6e-46 157.0 0.0 4.3e-46 156.2 0.0 1.3 1 0 0 1 1 1 1 UTP15 C terminal WD40 PF00400.32 CCF32131.1 - 2.3e-18 66.2 9.5 5.9e-06 26.9 0.1 5.5 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF32131.1 - 8.3e-07 29.2 0.0 0.093 13.0 0.0 4.1 3 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 CCF32131.1 - 0.019 15.0 0.0 1.4 8.9 0.0 3.3 2 1 1 3 3 3 0 Ciliary BBSome complex subunit 2, middle region WD40_3 PF15911.5 CCF32131.1 - 0.054 13.5 0.0 12 6.0 0.0 2.8 3 0 0 3 3 3 0 WD domain, G-beta repeat Ge1_WD40 PF16529.5 CCF32131.1 - 0.2 10.6 0.0 1.2 8.1 0.0 2.0 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Gln-synt_C PF00120.24 CCF32132.1 - 2.2e-14 53.2 0.0 3.9e-10 39.3 0.0 2.1 2 0 0 2 2 2 2 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 CCF32132.1 - 2.3e-11 43.2 0.0 5.6e-11 42.0 0.0 1.6 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain DUF2781 PF10914.8 CCF32134.1 - 7.3e-40 136.8 10.7 8.2e-40 136.6 10.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2781) Hydrolase_4 PF12146.8 CCF32136.1 - 0.15 11.3 0.0 0.19 11.0 0.0 1.1 1 0 0 1 1 1 0 Serine aminopeptidase, S33 DUF4347 PF14252.6 CCF32139.1 - 0.089 12.6 0.0 0.13 12.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4347) Pkinase PF00069.25 CCF32140.1 - 1.8e-43 148.8 0.0 2.2e-40 138.7 0.0 2.6 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCF32140.1 - 1.8e-14 53.7 0.0 2.1e-08 33.8 0.0 3.7 4 0 0 4 4 4 2 Protein tyrosine kinase APH PF01636.23 CCF32140.1 - 0.00042 20.3 0.1 0.1 12.5 0.0 2.5 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CCF32140.1 - 0.00083 18.2 0.0 0.0013 17.6 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 CCF32140.1 - 0.0079 15.6 0.0 0.62 9.4 0.0 2.7 3 0 0 3 3 3 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 CCF32140.1 - 0.054 12.8 0.0 6.5 6.0 0.0 2.3 2 0 0 2 2 2 0 Kinase-like CDC45 PF02724.14 CCF32140.1 - 4.7 5.4 4.9 6.7 4.9 4.9 1.2 1 0 0 1 1 1 0 CDC45-like protein Ribosomal_L27A PF00828.19 CCF32141.1 - 1.1e-21 77.9 0.0 1.6e-21 77.3 0.0 1.2 1 1 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Helicase_C_2 PF13307.6 CCF32142.1 - 8.9e-59 198.5 0.0 3.1e-58 196.7 0.0 2.0 2 0 0 2 2 2 1 Helicase C-terminal domain DEAD_2 PF06733.15 CCF32142.1 - 2.2e-47 160.9 0.0 3.8e-47 160.2 0.0 1.4 1 0 0 1 1 1 1 DEAD_2 GCV_T PF01571.21 CCF32143.1 - 2.2e-76 256.7 0.0 2.7e-76 256.3 0.0 1.1 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.11 CCF32143.1 - 1.3e-23 82.7 0.2 3.1e-23 81.5 0.2 1.7 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain Pkinase PF00069.25 CCF32144.1 - 2.9e-67 226.8 0.0 5e-67 226.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF32144.1 - 7.4e-37 127.0 0.0 1.3e-36 126.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF32144.1 - 5e-05 22.8 0.0 0.0001 21.7 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 CCF32144.1 - 0.0072 15.1 0.0 0.015 14.1 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 CCF32144.1 - 0.01 15.8 0.2 0.042 13.8 0.0 2.1 2 0 0 2 2 2 1 Phosphotransferase enzyme family NOG1_N PF17835.1 CCF32144.1 - 0.049 13.6 4.1 0.11 12.4 0.2 3.2 3 0 0 3 3 3 0 NOG1 N-terminal helical domain Syntaxin-6_N PF09177.11 CCF32144.1 - 0.06 13.9 2.2 0.18 12.4 0.1 2.9 3 0 0 3 3 3 0 Syntaxin 6, N-terminal Seadorna_VP7 PF07387.11 CCF32144.1 - 0.07 12.2 0.0 0.13 11.3 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Peptidase_S66 PF02016.15 CCF32145.1 - 2.1e-26 92.4 0.0 3.7e-26 91.6 0.0 1.4 1 0 0 1 1 1 1 LD-carboxypeptidase N-terminal domain Peptidase_S66C PF17676.1 CCF32145.1 - 2.5e-24 86.2 0.0 3.7e-24 85.6 0.0 1.3 1 0 0 1 1 1 1 LD-carboxypeptidase C-terminal domain MlaC PF05494.12 CCF32145.1 - 0.2 11.4 0.0 0.31 10.8 0.0 1.2 1 0 0 1 1 1 0 MlaC protein Peptidase_S8 PF00082.22 CCF32146.1 - 1.6e-11 44.0 0.0 1.8e-11 43.9 0.0 1.2 1 0 0 1 1 1 1 Subtilase family Glyco_transf_25 PF01755.17 CCF32147.1 - 3.2e-15 56.5 0.0 3.6e-10 40.0 0.0 2.1 2 0 0 2 2 2 2 Glycosyltransferase family 25 (LPS biosynthesis protein) DLH PF01738.18 CCF32148.1 - 3.1e-07 30.2 0.0 3.8e-07 29.9 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Chlorophyllase2 PF12740.7 CCF32148.1 - 0.16 10.8 0.0 0.2 10.6 0.0 1.1 1 0 0 1 1 1 0 Chlorophyllase enzyme Asp PF00026.23 CCF32149.1 - 2.9e-20 72.9 1.2 5.4e-14 52.3 0.7 2.7 1 1 1 2 2 2 2 Eukaryotic aspartyl protease Glyco_hydro_75 PF07335.11 CCF32150.1 - 1.5e-64 217.2 0.2 1.9e-64 216.9 0.2 1.1 1 0 0 1 1 1 1 Fungal chitosanase of glycosyl hydrolase group 75 Glyco_hydro_61 PF03443.14 CCF32152.1 - 1.8e-06 28.0 0.0 4.2e-06 26.8 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 DUF5349 PF17298.2 CCF32152.1 - 9.7 5.8 9.7 13 5.4 9.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5349) RPA_interact_N PF14766.6 CCF32153.1 - 1.3 8.8 3.7 0.68 9.6 0.9 1.9 2 0 0 2 2 2 0 Replication protein A interacting N-terminal DAO PF01266.24 CCF32155.1 - 4.6e-28 98.8 0.0 5.4e-28 98.6 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CCF32155.1 - 4.1e-07 30.1 0.0 2.1e-06 27.9 0.0 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 CCF32155.1 - 0.0086 15.4 0.1 0.016 14.5 0.0 1.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CCF32155.1 - 0.02 14.2 0.0 1.6 7.9 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CCF32155.1 - 0.052 12.8 0.0 0.083 12.1 0.0 1.3 1 0 0 1 1 1 0 Thi4 family FAD_binding_3 PF01494.19 CCF32155.1 - 0.072 12.3 0.0 0.13 11.5 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain ThiF PF00899.21 CCF32155.1 - 0.089 12.1 0.0 0.18 11.1 0.0 1.4 1 0 0 1 1 1 0 ThiF family TrkA_N PF02254.18 CCF32155.1 - 0.19 12.0 0.0 0.42 10.9 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain Fungal_trans PF04082.18 CCF32156.1 - 3.7e-14 52.4 0.6 6.5e-14 51.6 0.6 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Aa_trans PF01490.18 CCF32157.1 - 1.3e-26 93.3 12.1 1.4e-26 93.2 12.1 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 CCF32157.1 - 0.0051 15.9 15.1 0.006 15.7 14.7 1.4 1 1 0 1 1 1 1 Tryptophan/tyrosine permease family UPF0139 PF03669.13 CCF32157.1 - 2.8 7.9 6.2 1.7 8.6 1.7 2.7 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0139) Pirin PF02678.16 CCF32158.1 - 5.2e-25 87.5 0.7 1.4e-24 86.2 0.7 1.7 1 1 0 1 1 1 1 Pirin Cupin_2 PF07883.11 CCF32158.1 - 0.00065 19.4 2.6 0.059 13.1 0.5 3.0 2 1 0 2 2 2 2 Cupin domain AraC_binding_2 PF14525.6 CCF32158.1 - 0.022 14.4 0.0 0.042 13.5 0.0 1.4 1 0 0 1 1 1 0 AraC-binding-like domain Yae1_N PF09811.9 CCF32159.1 - 1.1e-11 44.2 1.5 1.1e-11 44.2 1.5 1.7 2 0 0 2 2 2 1 Essential protein Yae1, N terminal Pex14_N PF04695.13 CCF32161.1 - 6.3 7.4 8.1 8.9 6.9 8.1 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region ABC2_membrane PF01061.24 CCF32164.1 - 5.4e-76 254.7 60.8 4.6e-42 143.8 24.1 3.3 4 0 0 4 4 3 2 ABC-2 type transporter ABC_tran PF00005.27 CCF32164.1 - 1.5e-33 116.2 0.0 3.5e-16 60.0 0.0 2.4 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 CCF32164.1 - 1.4e-30 105.0 0.0 1.4e-30 105.0 0.0 3.6 4 0 0 4 4 2 2 CDR ABC transporter ABC_trans_N PF14510.6 CCF32164.1 - 9.2e-15 55.0 0.0 4e-14 53.0 0.0 2.1 2 0 0 2 2 1 1 ABC-transporter N-terminal ABC2_membrane_3 PF12698.7 CCF32164.1 - 8.4e-08 31.7 37.1 6e-05 22.3 13.0 2.7 2 1 0 2 2 2 2 ABC-2 family transporter protein AAA_16 PF13191.6 CCF32164.1 - 3.8e-06 27.4 0.1 0.089 13.2 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_25 PF13481.6 CCF32164.1 - 2.6e-05 23.9 0.1 0.00012 21.7 0.0 2.0 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 CCF32164.1 - 7.5e-05 22.7 0.1 0.0037 17.2 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_29 PF13555.6 CCF32164.1 - 0.00021 21.0 1.7 0.043 13.6 0.2 2.4 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_33 PF13671.6 CCF32164.1 - 0.00072 19.7 1.2 0.031 14.4 0.1 3.2 3 0 0 3 3 3 1 AAA domain AAA_21 PF13304.6 CCF32164.1 - 0.0011 18.8 0.5 1.5 8.6 0.0 2.5 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CCF32164.1 - 0.0017 17.8 0.0 0.1 12.0 0.0 2.9 3 1 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_17 PF13207.6 CCF32164.1 - 0.0033 17.9 0.2 0.11 12.9 0.0 2.8 3 0 0 3 3 2 1 AAA domain AAA_22 PF13401.6 CCF32164.1 - 0.0081 16.4 0.4 1.7 8.9 0.2 2.9 3 0 0 3 3 3 1 AAA domain AAA_18 PF13238.6 CCF32164.1 - 0.017 15.6 0.1 0.16 12.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 CCF32164.1 - 0.022 14.5 0.7 0.92 9.2 0.1 2.5 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 CCF32164.1 - 0.07 13.2 0.6 6.7 6.8 0.1 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_23 PF13476.6 CCF32164.1 - 0.071 13.6 0.0 0.14 12.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 CCF32164.1 - 0.098 12.6 2.0 5.5 6.9 0.1 2.8 3 0 0 3 3 2 0 NACHT domain cobW PF02492.19 CCF32164.1 - 0.11 12.1 2.9 0.26 10.8 0.1 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA PF00004.29 CCF32164.1 - 0.12 12.8 0.1 12 6.4 0.0 2.6 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 CCF32164.1 - 0.15 11.3 0.4 0.76 9.0 0.0 2.1 2 0 0 2 2 2 0 Zeta toxin AAA_28 PF13521.6 CCF32164.1 - 0.25 11.5 0.9 0.57 10.4 0.0 2.1 2 0 0 2 2 1 0 AAA domain PDR_assoc PF08370.11 CCF32164.1 - 0.34 10.7 8.6 9.9 6.0 0.3 3.7 3 0 0 3 3 3 0 Plant PDR ABC transporter associated Bac_luciferase PF00296.20 CCF32165.1 - 4.1e-54 184.1 0.0 4.8e-54 183.9 0.0 1.0 1 0 0 1 1 1 1 Luciferase-like monooxygenase TIP49 PF06068.13 CCF32166.1 - 8.6e-21 74.5 0.3 9.6e-21 74.4 0.3 1.0 1 0 0 1 1 1 1 TIP49 P-loop domain KASH_CCD PF14662.6 CCF32167.1 - 0.00027 20.8 11.0 0.00027 20.8 11.0 4.2 2 1 2 4 4 4 2 Coiled-coil region of CCDC155 or KASH Tropomyosin_1 PF12718.7 CCF32167.1 - 0.00037 20.7 1.9 0.00037 20.7 1.9 6.4 4 3 0 5 5 5 1 Tropomyosin like TACC_C PF05010.14 CCF32167.1 - 0.00064 19.6 2.2 0.00064 19.6 2.2 5.1 4 2 0 4 4 4 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Atg14 PF10186.9 CCF32167.1 - 0.0021 17.2 9.4 0.0021 17.2 9.4 4.3 3 1 1 4 4 4 1 Vacuolar sorting 38 and autophagy-related subunit 14 CALCOCO1 PF07888.11 CCF32167.1 - 0.0038 16.1 45.0 0.029 13.3 5.8 4.0 2 2 0 2 2 2 1 Calcium binding and coiled-coil domain (CALCOCO1) like ZapB PF06005.12 CCF32167.1 - 0.0049 17.3 0.7 0.0049 17.3 0.7 7.5 5 3 1 7 7 7 2 Cell division protein ZapB KELK PF15796.5 CCF32167.1 - 0.0049 17.3 5.4 0.0049 17.3 5.4 5.9 5 1 1 6 6 5 2 KELK-motif containing domain of MRCK Ser/Thr protein kinase HALZ PF02183.18 CCF32167.1 - 0.0067 16.6 34.9 0.057 13.7 0.2 7.0 6 2 1 7 7 6 3 Homeobox associated leucine zipper BLOC1_2 PF10046.9 CCF32167.1 - 0.01 16.1 30.7 0.021 15.1 0.1 7.1 4 2 2 6 6 6 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF2968 PF11180.8 CCF32167.1 - 0.013 15.1 7.8 0.013 15.1 7.8 5.6 4 1 1 5 5 5 0 Protein of unknown function (DUF2968) YabA PF06156.13 CCF32167.1 - 0.019 15.6 33.0 0.26 11.9 5.3 5.8 4 2 1 5 5 5 0 Initiation control protein YabA HrpB7 PF09486.10 CCF32167.1 - 0.029 14.8 0.3 0.029 14.8 0.3 5.9 3 3 1 5 5 5 0 Bacterial type III secretion protein (HrpB7) HisKA PF00512.25 CCF32167.1 - 0.14 12.2 6.6 1.4 9.0 0.0 4.3 3 1 1 4 4 3 0 His Kinase A (phospho-acceptor) domain CT_C_D PF02682.16 CCF32167.1 - 0.15 11.7 1.6 0.49 10.1 0.1 2.6 3 0 0 3 3 3 0 Carboxyltransferase domain, subdomain C and D DUF782 PF05614.11 CCF32167.1 - 0.16 12.4 0.0 0.34 11.3 0.0 1.5 1 0 0 1 1 1 0 Circovirus protein of unknown function (DUF782) AAA_13 PF13166.6 CCF32167.1 - 0.34 9.5 32.6 0.022 13.4 5.7 4.2 2 2 2 4 4 4 0 AAA domain CENP-F_leu_zip PF10473.9 CCF32167.1 - 0.42 10.6 48.9 0.085 12.9 3.7 5.9 2 2 4 6 6 6 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4686 PF15742.5 CCF32167.1 - 0.8 8.8 51.7 0.11 11.6 2.5 4.9 2 2 3 5 5 5 0 Domain of unknown function (DUF4686) DUF5082 PF16888.5 CCF32167.1 - 1.2 9.4 42.5 0.35 11.1 0.9 7.1 4 3 2 6 6 6 0 Domain of unknown function (DUF5082) Spc7 PF08317.11 CCF32167.1 - 2.2 7.1 53.8 0.1 11.4 12.4 5.9 2 2 3 6 6 6 0 Spc7 kinetochore protein HSBP1 PF06825.12 CCF32167.1 - 2.6 8.0 0.0 2.6 8.0 0.0 6.0 6 1 0 6 6 6 0 Heat shock factor binding protein 1 HMMR_N PF15905.5 CCF32167.1 - 3.6 7.0 40.4 2.2 7.7 6.3 5.1 3 1 0 4 4 4 0 Hyaluronan mediated motility receptor N-terminal FapA PF03961.13 CCF32167.1 - 4.2 5.9 27.1 0.36 9.4 3.4 4.2 4 0 0 4 4 4 0 Flagellar Assembly Protein A Vac_Fusion PF02346.16 CCF32167.1 - 5.6 6.7 9.5 11 5.8 0.0 5.2 6 0 0 6 6 6 0 Chordopoxvirus multifunctional envelope protein A27 TSC22 PF01166.18 CCF32167.1 - 6.2 7.2 19.4 39 4.7 0.5 6.6 5 1 3 8 8 7 0 TSC-22/dip/bun family Glyco_hydro_18 PF00704.28 CCF32170.1 - 3.9e-47 161.5 0.0 6.3e-47 160.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 LysM PF01476.20 CCF32170.1 - 6.1e-09 35.8 0.0 0.1 12.7 0.0 4.2 4 0 0 4 4 4 3 LysM domain Chitin_bind_1 PF00187.19 CCF32170.1 - 4.7e-05 23.8 11.6 4.7e-05 23.8 11.6 3.2 2 0 0 2 2 2 1 Chitin recognition protein LPD37 PF18853.1 CCF32170.1 - 0.027 14.0 0.0 0.045 13.3 0.0 1.2 1 0 0 1 1 1 0 Large polyvalent protein associated domain 37 Peptidase_S8 PF00082.22 CCF32172.1 - 3.3e-19 69.2 2.5 5.3e-19 68.6 2.5 1.3 1 0 0 1 1 1 1 Subtilase family DAHP_snth_FXD PF18152.1 CCF32172.1 - 0.051 13.4 0.1 0.29 11.0 0.1 2.3 1 1 0 1 1 1 0 DAHP synthase ferredoxin-like domain Inhibitor_I9 PF05922.16 CCF32172.1 - 0.19 12.4 0.0 0.54 11.0 0.0 1.8 1 1 0 1 1 1 0 Peptidase inhibitor I9 zf-RING_2 PF13639.6 CCF32173.1 - 1.4e-08 34.9 6.6 1.4e-08 34.9 6.6 2.3 2 0 0 2 2 2 1 Ring finger domain FANCL_C PF11793.8 CCF32173.1 - 4.6e-05 23.5 11.2 0.00023 21.3 8.0 2.5 2 1 0 2 2 2 1 FANCL C-terminal domain zf-RING_UBOX PF13445.6 CCF32173.1 - 0.0012 18.8 3.8 0.0033 17.4 3.8 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 CCF32173.1 - 0.0032 17.5 2.2 0.0032 17.5 2.2 2.1 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger PHD PF00628.29 CCF32173.1 - 0.0066 16.3 7.8 0.018 14.9 7.8 1.8 1 0 0 1 1 1 1 PHD-finger zf-RING_5 PF14634.6 CCF32173.1 - 0.012 15.6 6.9 0.012 15.6 6.9 1.8 2 0 0 2 2 2 0 zinc-RING finger domain zf-rbx1 PF12678.7 CCF32173.1 - 0.017 15.4 5.4 0.017 15.4 5.4 2.0 2 0 0 2 2 2 0 RING-H2 zinc finger domain Zf_RING PF16744.5 CCF32173.1 - 0.34 11.0 5.0 0.74 10.0 2.7 2.4 2 0 0 2 2 2 0 KIAA1045 RING finger Pkinase PF00069.25 CCF32174.1 - 1.2e-10 41.2 0.0 1.9e-10 40.6 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF32174.1 - 1.4e-07 31.0 0.0 2.4e-07 30.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase FAD_binding_4 PF01565.23 CCF32176.1 - 8.9e-21 74.1 2.5 1.8e-20 73.1 2.5 1.6 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 CCF32176.1 - 0.0012 18.9 0.7 0.0036 17.4 0.1 2.0 2 0 0 2 2 2 1 Berberine and berberine like IN_DBD_C PF00552.21 CCF32176.1 - 0.19 11.1 0.0 0.45 9.8 0.0 1.5 1 0 0 1 1 1 0 Integrase DNA binding domain Sugar_tr PF00083.24 CCF32177.1 - 1.7e-84 284.3 19.8 2e-84 284.1 19.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF32177.1 - 1.8e-35 122.6 40.9 1.3e-28 100.0 28.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Folate_carrier PF01770.18 CCF32177.1 - 0.015 14.0 0.2 0.36 9.5 0.0 2.2 2 0 0 2 2 2 0 Reduced folate carrier Phage_holin_3_2 PF04550.12 CCF32177.1 - 0.032 14.8 0.1 0.094 13.3 0.1 1.8 1 0 0 1 1 1 0 Phage holin family 2 FMO-like PF00743.19 CCF32178.1 - 2.4e-21 75.8 0.0 1.3e-09 37.1 0.0 3.1 3 0 0 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 CCF32178.1 - 1.2e-09 37.9 0.1 1.6e-07 30.9 0.1 2.8 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CCF32178.1 - 5.7e-07 29.6 1.0 0.046 13.7 0.0 3.2 3 0 0 3 3 3 2 FAD-NAD(P)-binding K_oxygenase PF13434.6 CCF32178.1 - 1.9e-05 24.0 2.0 0.0059 15.8 0.1 3.6 3 1 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 CCF32178.1 - 0.00014 21.2 0.0 0.0015 17.9 0.0 2.4 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCF32178.1 - 0.0013 18.9 0.0 0.0034 17.6 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Sugar_tr PF00083.24 CCF32179.1 - 1.9e-85 287.4 25.3 2.2e-85 287.3 25.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF32179.1 - 3.1e-16 59.3 41.9 4.2e-12 45.7 20.8 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_3 PF05977.13 CCF32179.1 - 0.0053 15.2 2.8 0.0097 14.3 0.1 2.2 2 0 0 2 2 2 1 Transmembrane secretion effector MttA_Hcf106 PF02416.16 CCF32179.1 - 1 8.8 2.7 6.8 6.1 0.1 3.1 3 0 0 3 3 3 0 mttA/Hcf106 family DUF417 PF04224.12 CCF32179.1 - 4.7 6.7 6.9 0.44 10.1 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function, DUF417 Glyco_hydro_43 PF04616.14 CCF32180.1 - 9.6e-23 80.9 0.0 1.3e-22 80.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 HeLo PF14479.6 CCF32181.1 - 8.2e-17 61.7 0.0 1.8e-15 57.3 0.0 2.0 1 1 0 1 1 1 1 Prion-inhibition and propagation Dynactin_p62 PF05502.13 CCF32184.1 - 0.085 11.6 0.8 0.11 11.2 0.8 1.1 1 0 0 1 1 1 0 Dynactin p62 family Polysacc_lyase PF14099.6 CCF32185.1 - 0.06 13.2 0.2 0.084 12.7 0.2 1.4 1 0 0 1 1 1 0 Polysaccharide lyase Methyltransf_23 PF13489.6 CCF32188.1 - 4.7e-22 78.6 0.0 7e-22 78.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF32188.1 - 1.4e-06 28.1 0.0 4.5e-05 23.3 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF32188.1 - 1.8e-06 28.6 0.0 3.7e-06 27.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF32188.1 - 1.2e-05 25.9 0.0 2.6e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain CheR PF01739.18 CCF32188.1 - 0.002 17.6 0.0 0.0036 16.8 0.0 1.3 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain Methyltransf_12 PF08242.12 CCF32188.1 - 0.0067 17.2 0.0 0.056 14.2 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain DDE_1 PF03184.19 CCF32189.1 - 4.8e-38 130.5 0.1 7.6e-38 129.9 0.1 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 CCF32189.1 - 0.00082 19.2 2.4 0.0012 18.6 0.0 2.3 3 0 0 3 3 3 1 DDE superfamily endonuclease NAD_binding_8 PF13450.6 CCF32190.1 - 0.0031 17.7 0.1 0.042 14.1 0.0 2.7 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain Shikimate_DH PF01488.20 CCF32190.1 - 0.0058 16.7 0.0 0.26 11.3 0.0 2.3 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase K_oxygenase PF13434.6 CCF32190.1 - 0.071 12.2 0.0 0.14 11.2 0.0 1.5 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 CCF32190.1 - 0.12 11.6 0.0 15 4.7 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Sacchrp_dh_NADP PF03435.18 CCF32190.1 - 0.18 12.1 0.0 2.6 8.3 0.0 2.3 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain HTH_Tnp_Tc5 PF03221.16 CCF32191.1 - 1e-10 41.5 0.1 2.6e-10 40.2 0.1 1.7 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 CCF32191.1 - 2.2e-08 33.7 0.1 4e-08 32.9 0.1 1.4 1 0 0 1 1 1 1 helix-turn-helix, Psq domain DDE_1 PF03184.19 CCF32191.1 - 2.7e-05 23.9 0.0 8.6e-05 22.3 0.0 1.8 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_28 PF13518.6 CCF32191.1 - 0.002 18.2 0.6 0.0078 16.3 0.2 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.6 CCF32191.1 - 0.0068 16.2 0.1 0.018 14.8 0.1 1.7 1 0 0 1 1 1 1 Homeodomain-like domain HTH_7 PF02796.15 CCF32191.1 - 0.0068 16.5 0.6 0.013 15.6 0.6 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_Tnp_IS630 PF01710.16 CCF32191.1 - 0.025 14.6 0.0 0.044 13.8 0.0 1.4 1 0 0 1 1 1 0 Transposase HTH_Tnp_ISL3 PF13542.6 CCF32191.1 - 0.058 12.8 0.0 0.11 11.9 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 HTH_8 PF02954.19 CCF32191.1 - 0.061 13.1 0.2 0.18 11.6 0.2 1.8 1 1 0 1 1 1 0 Bacterial regulatory protein, Fis family Methyltransf_11 PF08241.12 CCF32192.1 - 3.1e-11 43.8 0.0 6.4e-11 42.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF32192.1 - 7.1e-11 42.7 0.0 1.3e-10 41.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF32192.1 - 1.3e-05 25.1 0.0 2.8e-05 24.0 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF32192.1 - 1.5e-05 25.6 0.0 3.4e-05 24.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCF32192.1 - 0.00014 21.2 0.0 0.0002 20.8 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 CCF32192.1 - 0.0026 17.6 0.0 0.005 16.7 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain DREV PF05219.12 CCF32192.1 - 0.0054 15.9 0.0 0.0072 15.4 0.0 1.3 1 0 0 1 1 1 1 DREV methyltransferase MTS PF05175.14 CCF32192.1 - 0.021 14.4 0.0 0.034 13.7 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain RrnaAD PF00398.20 CCF32192.1 - 0.047 12.8 0.0 0.065 12.3 0.0 1.1 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase FtsJ PF01728.19 CCF32192.1 - 0.049 13.7 0.0 0.078 13.1 0.0 1.2 1 0 0 1 1 1 0 FtsJ-like methyltransferase DUF3169 PF11368.8 CCF32193.1 - 0.021 14.4 0.2 0.029 13.9 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3169) Suf PF05843.14 CCF32194.1 - 1.9e-14 54.4 8.2 0.0025 17.8 0.0 5.7 3 1 1 5 5 5 4 Suppressor of forked protein (Suf) TPR_14 PF13428.6 CCF32194.1 - 1.3e-11 44.3 20.2 0.87 10.6 0.0 10.7 9 3 3 12 12 11 3 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 CCF32194.1 - 1.3e-07 31.7 6.8 0.22 11.5 0.1 6.2 6 0 0 6 6 6 3 Mad3/BUB1 homology region 1 TPR_15 PF13429.6 CCF32194.1 - 2.5e-07 30.2 4.4 6.8e-05 22.2 0.8 3.8 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 CCF32194.1 - 2.8e-07 30.7 2.8 3.4 8.0 0.0 6.7 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_8 PF13181.6 CCF32194.1 - 4.5e-07 29.6 2.7 0.88 9.9 0.0 6.3 7 0 0 7 7 5 1 Tetratricopeptide repeat TPR_2 PF07719.17 CCF32194.1 - 0.00013 21.8 18.1 0.013 15.6 0.0 7.6 10 0 0 10 10 9 1 Tetratricopeptide repeat RPN7 PF10602.9 CCF32194.1 - 0.00023 20.9 0.9 0.0078 15.9 0.3 3.3 2 2 0 2 2 2 1 26S proteasome subunit RPN7 TPR_10 PF13374.6 CCF32194.1 - 0.0022 17.8 10.9 2.2 8.3 0.0 7.0 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_4 PF07721.14 CCF32194.1 - 0.011 16.3 0.1 0.9 10.4 0.0 3.6 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_17 PF13431.6 CCF32194.1 - 0.015 15.7 3.7 40 4.9 0.0 6.1 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_1 PF00515.28 CCF32194.1 - 0.017 14.9 0.1 0.87 9.5 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat MIT PF04212.18 CCF32194.1 - 0.026 14.6 0.0 1 9.5 0.1 3.5 4 0 0 4 4 3 0 MIT (microtubule interacting and transport) domain TPR_16 PF13432.6 CCF32194.1 - 0.13 12.9 1.0 28 5.5 0.0 4.6 5 0 0 5 5 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 CCF32194.1 - 0.16 12.0 4.8 0.49 10.5 0.0 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat LEM PF03020.15 CCF32194.1 - 0.64 9.6 1.9 23 4.7 0.0 3.1 3 0 0 3 3 3 0 LEM domain TPR_6 PF13174.6 CCF32194.1 - 2.7 8.8 11.0 61 4.6 0.0 6.8 7 1 1 8 8 6 0 Tetratricopeptide repeat Egh16-like PF11327.8 CCF32196.1 - 2.8e-53 181.1 9.1 3.4e-53 180.8 9.1 1.1 1 0 0 1 1 1 1 Egh16-like virulence factor DDE_1 PF03184.19 CCF32197.1 - 2e-08 34.1 0.0 2.6e-08 33.7 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease IBR PF01485.21 CCF32198.1 - 2.5e-09 37.2 47.2 9.7e-07 28.9 5.6 3.9 4 0 0 4 4 4 3 IBR domain, a half RING-finger domain GHMP_kinases_N PF00288.26 CCF32199.1 - 1.3e-15 57.3 2.5 2.9e-15 56.2 2.5 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 CCF32199.1 - 3e-07 30.7 0.1 7.6e-07 29.4 0.1 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal Rib_5-P_isom_A PF06026.14 CCF32200.1 - 2.1e-44 151.2 0.0 7.7e-44 149.3 0.0 1.7 1 1 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) DeoRC PF00455.22 CCF32200.1 - 0.043 13.7 0.0 9.6 6.1 0.0 2.2 2 0 0 2 2 2 0 DeoR C terminal sensor domain PPR_2 PF13041.6 CCF32201.1 - 3.8e-25 87.8 14.8 1.9e-08 34.3 0.0 9.6 6 3 5 11 11 11 4 PPR repeat family PPR_3 PF13812.6 CCF32201.1 - 2e-22 79.0 0.3 0.0012 18.9 0.0 7.6 4 2 3 8 8 8 6 Pentatricopeptide repeat domain PPR PF01535.20 CCF32201.1 - 1.5e-14 53.2 22.8 0.00056 20.0 0.1 10.1 11 1 0 11 11 11 4 PPR repeat PPR_1 PF12854.7 CCF32201.1 - 1.5e-14 53.4 0.0 6.6e-08 32.1 0.0 5.8 5 0 0 5 5 5 3 PPR repeat PPR_long PF17177.4 CCF32201.1 - 1.9e-12 47.0 4.8 1.7e-08 34.1 0.3 3.5 2 1 1 3 3 3 2 Pentacotripeptide-repeat region of PRORP TPR_7 PF13176.6 CCF32201.1 - 0.074 13.1 0.7 4.5 7.5 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TMEM51 PF15345.6 CCF32202.1 - 0.01 15.7 0.2 0.01 15.7 0.2 1.2 1 0 0 1 1 1 0 Transmembrane protein 51 Ni_hydr_CYTB PF01292.20 CCF32202.1 - 0.092 12.3 0.0 0.092 12.3 0.0 1.1 1 0 0 1 1 1 0 Prokaryotic cytochrome b561 Aminotran_5 PF00266.19 CCF32203.1 - 7.5e-33 114.0 0.0 2.8e-22 79.2 0.0 2.1 1 1 1 2 2 2 2 Aminotransferase class-V MFS_MOT1 PF16983.5 CCF32204.1 - 4.3e-65 217.1 28.4 1.1e-36 125.7 8.5 2.6 3 0 0 3 3 3 2 Molybdate transporter of MFS superfamily Mntp PF02659.15 CCF32204.1 - 1.8 8.3 10.0 0.93 9.2 0.1 3.5 4 0 0 4 4 4 0 Putative manganese efflux pump MTS PF05175.14 CCF32206.1 - 5.9e-07 29.2 0.0 1.1e-06 28.3 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.6 CCF32206.1 - 6.1e-06 26.1 0.0 1.3e-05 25.0 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF32206.1 - 0.002 18.8 0.0 0.0069 17.1 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF32206.1 - 0.0063 16.4 0.0 0.0091 15.8 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain PrmC_N PF17827.1 CCF32206.1 - 0.0074 16.8 0.4 0.031 14.9 0.1 2.2 2 1 1 3 3 3 1 PrmC N-terminal domain N6_Mtase PF02384.16 CCF32206.1 - 0.0098 15.2 0.0 0.014 14.7 0.0 1.2 1 0 0 1 1 1 1 N-6 DNA Methylase PrmA PF06325.13 CCF32206.1 - 0.012 15.0 0.0 0.017 14.6 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_32 PF13679.6 CCF32206.1 - 0.079 12.9 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain WD40 PF00400.32 CCF32207.1 - 1.6e-15 57.2 4.7 0.011 16.6 0.0 6.4 7 1 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF32207.1 - 8.9e-08 32.3 0.1 0.024 14.9 0.0 5.1 3 1 3 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 CCF32207.1 - 5.9e-05 22.8 6.0 0.14 11.7 0.0 2.3 1 1 1 2 2 2 2 PQQ-like domain PQQ PF01011.21 CCF32207.1 - 0.03 14.2 1.2 20 5.3 0.1 4.1 4 0 0 4 4 4 0 PQQ enzyme repeat PQQ_3 PF13570.6 CCF32207.1 - 0.64 10.6 9.7 14 6.3 0.2 4.5 4 0 0 4 4 4 0 PQQ-like domain Glyco_transf_15 PF01793.16 CCF32208.1 - 1.4e-115 386.1 10.1 1.7e-115 385.8 10.1 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Transferase PF02458.15 CCF32210.1 - 4.2e-06 25.7 0.0 0.0003 19.6 0.0 2.4 2 1 0 2 2 2 2 Transferase family tRNA-synt_2 PF00152.20 CCF32211.1 - 1.9e-73 247.3 0.0 3.1e-73 246.6 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) DUF2156 PF09924.9 CCF32211.1 - 5.6e-14 51.9 0.1 7.4e-14 51.4 0.1 1.2 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2156) tRNA_anti-codon PF01336.25 CCF32211.1 - 4.2e-09 36.3 0.0 1.1e-08 34.9 0.0 1.8 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain Rgp1 PF08737.10 CCF32211.1 - 0.015 14.5 2.7 0.49 9.5 0.0 2.1 2 0 0 2 2 2 0 Rgp1 SOBP PF15279.6 CCF32211.1 - 1 9.9 5.3 1.8 9.1 5.3 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein SprA-related PF12118.8 CCF32211.1 - 1.4 8.0 7.7 2.5 7.2 7.7 1.3 1 0 0 1 1 1 0 SprA-related family SR-25 PF10500.9 CCF32211.1 - 4.1 7.0 23.1 0.12 12.0 16.7 1.6 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein CRC_subunit PF08624.10 CCF32212.1 - 4.1e-52 176.2 0.0 5.9e-52 175.7 0.0 1.2 1 0 0 1 1 1 1 Chromatin remodelling complex Rsc7/Swp82 subunit Actin PF00022.19 CCF32213.1 - 1.8e-100 336.4 0.0 1.7e-99 333.2 0.0 1.9 1 1 0 1 1 1 1 Actin Cupin_1 PF00190.22 CCF32214.1 - 3.4e-21 75.5 0.8 4.8e-21 74.9 0.8 1.1 1 0 0 1 1 1 1 Cupin Cupin_2 PF07883.11 CCF32214.1 - 4e-05 23.3 0.0 8.4e-05 22.2 0.0 1.6 1 0 0 1 1 1 1 Cupin domain F-box PF00646.33 CCF32215.1 - 0.13 12.2 0.1 0.29 11.1 0.1 1.6 1 0 0 1 1 1 0 F-box domain Sulfotransfer_4 PF17784.1 CCF32216.1 - 1.1e-17 64.6 0.3 2e-17 63.8 0.3 1.4 1 0 0 1 1 1 1 Sulfotransferase domain DPM3 PF08285.11 CCF32217.1 - 2.1e-36 124.0 0.2 2.3e-36 123.8 0.2 1.0 1 0 0 1 1 1 1 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) RhgB_N PF09284.10 CCF32218.1 - 5.2e-101 337.4 0.0 6.9e-101 337.0 0.0 1.2 1 0 0 1 1 1 1 Rhamnogalacturonan lyase B, N-terminal CBM-like PF14683.6 CCF32218.1 - 5.2e-35 120.8 0.0 1e-34 119.8 0.0 1.5 1 0 0 1 1 1 1 Polysaccharide lyase family 4, domain III fn3_3 PF14686.6 CCF32218.1 - 2.7e-19 68.7 2.5 1e-18 66.8 2.5 2.1 1 0 0 1 1 1 1 Polysaccharide lyase family 4, domain II CarboxypepD_reg PF13620.6 CCF32218.1 - 0.0043 17.3 1.4 0.0043 17.3 1.4 2.3 3 1 0 3 3 3 1 Carboxypeptidase regulatory-like domain WSC PF01822.19 CCF32219.1 - 1e-55 185.9 50.7 8.3e-19 67.6 7.9 4.7 4 0 0 4 4 4 4 WSC domain ASH PF15780.5 CCF32219.1 - 1e-05 25.6 0.2 0.27 11.5 0.2 2.8 2 0 0 2 2 2 2 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin DUF1573 PF07610.11 CCF32219.1 - 0.074 13.1 0.0 34 4.6 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1573) PQQ_3 PF13570.6 CCF32219.1 - 0.82 10.2 11.6 14 6.3 0.0 5.5 5 0 0 5 5 5 0 PQQ-like domain Peptidase_M20 PF01546.28 CCF32220.1 - 1.6e-24 86.7 0.0 2.2e-23 83.1 0.0 2.5 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 CCF32220.1 - 1.3e-06 28.3 0.0 2.6e-06 27.3 0.0 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain ELMO_CED12 PF04727.13 CCF32221.1 - 1.3e-49 168.7 0.1 2.8e-49 167.6 0.0 1.6 2 0 0 2 2 2 1 ELMO/CED-12 family PH_12 PF16457.5 CCF32221.1 - 2.3e-42 144.7 0.1 4.6e-42 143.7 0.1 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain DUF3361 PF11841.8 CCF32221.1 - 3.7e-13 49.7 0.0 1.4e-12 47.8 0.0 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF3361) MgpC PF05220.12 CCF32221.1 - 0.063 12.6 0.0 0.1 11.9 0.0 1.3 1 0 0 1 1 1 0 MgpC protein precursor zf-GRF PF06839.12 CCF32222.1 - 8.8e-10 38.5 6.5 1.4e-09 37.9 6.5 1.3 1 0 0 1 1 1 1 GRF zinc finger Prefoldin_2 PF01920.20 CCF32222.1 - 0.0053 16.7 0.4 0.011 15.6 0.4 1.4 1 0 0 1 1 1 1 Prefoldin subunit PKcGMP_CC PF16808.5 CCF32222.1 - 0.026 14.4 1.9 0.085 12.7 1.9 1.8 1 1 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase bZIP_1 PF00170.21 CCF32222.1 - 0.051 13.7 1.9 0.055 13.6 0.4 1.7 2 0 0 2 2 2 0 bZIP transcription factor TMF_DNA_bd PF12329.8 CCF32222.1 - 0.061 13.3 0.7 0.061 13.3 0.7 1.8 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DivIC PF04977.15 CCF32222.1 - 0.1 12.4 0.6 0.26 11.1 0.6 1.6 1 0 0 1 1 1 0 Septum formation initiator Nucleo_P87 PF07267.11 CCF32222.1 - 9.2 5.0 9.5 0.72 8.6 4.1 1.7 1 1 1 2 2 2 0 Nucleopolyhedrovirus capsid protein P87 DUF3818 PF12825.7 CCF32223.1 - 8.7e-130 432.7 4.9 1.5e-129 431.9 4.9 1.4 1 0 0 1 1 1 1 Domain of unknown function in PX-proteins (DUF3818) PXB PF12828.7 CCF32223.1 - 7.9e-40 135.9 2.2 8.8e-40 135.7 0.4 2.0 2 0 0 2 2 2 1 PX-associated PX PF00787.24 CCF32223.1 - 7.4e-14 51.7 0.0 3.9e-13 49.4 0.0 2.3 2 1 0 2 2 2 1 PX domain Myc_N PF01056.18 CCF32223.1 - 0.012 15.6 1.6 0.026 14.4 1.6 1.5 1 0 0 1 1 1 0 Myc amino-terminal region Cwf_Cwc_15 PF04889.12 CCF32223.1 - 0.07 12.9 5.3 0.19 11.4 5.3 1.7 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF3802 PF12290.8 CCF32223.1 - 0.075 13.5 1.1 0.32 11.5 1.1 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3802) Fib_alpha PF08702.10 CCF32224.1 - 0.036 14.3 0.4 0.2 11.8 0.4 2.1 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Sigma_reg_N PF13800.6 CCF32224.1 - 0.049 13.9 0.0 0.1 12.9 0.0 1.5 1 0 0 1 1 1 0 Sigma factor regulator N-terminal DUF812 PF05667.11 CCF32224.1 - 0.057 12.3 0.1 0.061 12.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF812) DotU PF09850.9 CCF32224.1 - 0.13 12.0 3.8 0.23 11.2 1.1 2.5 2 1 1 3 3 3 0 Type VI secretion system protein DotU DUF1514 PF07438.11 CCF32224.1 - 0.2 11.5 2.4 0.49 10.3 2.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1514) Cgr1 PF03879.14 CCF32225.1 - 2.8e-34 117.8 32.2 3.3e-34 117.5 32.2 1.1 1 0 0 1 1 1 1 Cgr1 family RR_TM4-6 PF06459.12 CCF32225.1 - 8.6 6.1 18.3 10 5.9 18.3 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Sulfatase PF00884.23 CCF32226.1 - 4.7e-17 62.3 0.0 8.7e-17 61.5 0.0 1.5 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 CCF32226.1 - 6.8e-05 22.6 0.1 0.00016 21.4 0.0 1.6 2 0 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.17 CCF32226.1 - 0.056 12.0 0.0 0.092 11.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF229) Glyco_hydro_11 PF00457.17 CCF32229.1 - 9.8e-79 263.1 21.8 1.2e-78 262.8 21.8 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 11 Hydrolase PF00702.26 CCF32230.1 - 8.6e-07 29.5 0.0 2.5e-06 27.9 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 CCF32230.1 - 0.012 15.7 0.0 0.017 15.2 0.0 1.4 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 CCF32230.1 - 0.028 14.5 0.0 9.6 6.4 0.0 2.3 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase DAO PF01266.24 CCF32231.1 - 5.2e-44 151.3 0.2 6e-44 151.1 0.2 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 CCF32231.1 - 0.00075 19.5 0.2 0.17 11.8 0.1 2.5 2 0 0 2 2 2 2 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 CCF32231.1 - 0.053 12.7 0.4 5.2 6.2 0.4 2.6 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CCF32231.1 - 0.13 10.9 0.1 0.25 10.0 0.0 1.4 2 0 0 2 2 2 0 HI0933-like protein Questin_oxidase PF14027.6 CCF32232.1 - 7.1e-75 252.7 0.6 9.2e-75 252.3 0.6 1.1 1 0 0 1 1 1 1 Questin oxidase-like DUF2516 PF10724.9 CCF32232.1 - 0.045 14.0 0.2 0.17 12.2 0.0 2.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2516) STI1 PF17830.1 CCF32232.1 - 0.11 12.5 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 STI1 domain MFS_1 PF07690.16 CCF32233.1 - 4e-43 147.7 35.6 4e-43 147.7 35.6 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF2583 PF10762.9 CCF32233.1 - 1.8 9.0 5.2 0.67 10.4 0.4 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF2583) Peptidase_S15 PF02129.18 CCF32234.1 - 4.5e-30 105.1 0.2 8.3e-25 87.9 0.1 3.1 1 1 1 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) PepX_C PF08530.10 CCF32234.1 - 1.7e-10 41.2 0.0 3.3e-06 27.2 0.0 2.7 1 1 0 2 2 2 2 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain HSP70 PF00012.20 CCF32235.1 - 2.1e-07 29.5 0.0 2.3e-05 22.8 0.0 2.3 2 1 0 2 2 2 2 Hsp70 protein FGGY_C PF02782.16 CCF32235.1 - 0.00011 22.1 0.0 0.0012 18.6 0.0 2.1 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain MreB_Mbl PF06723.13 CCF32235.1 - 0.027 13.3 0.0 0.12 11.1 0.0 1.9 1 1 0 1 1 1 0 MreB/Mbl protein ArnB_C PF18677.1 CCF32235.1 - 0.13 12.4 0.0 5.1 7.3 0.0 2.5 2 0 0 2 2 2 0 Archaellum regulatory network B, C-terminal domain AIG1 PF04548.16 CCF32236.1 - 1.8e-10 40.5 0.0 3.8e-10 39.5 0.0 1.5 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.23 CCF32236.1 - 8.4e-07 29.1 0.6 1.9e-06 27.9 0.0 1.9 2 1 0 2 2 2 1 50S ribosome-binding GTPase Septin PF00735.18 CCF32236.1 - 2.3e-05 23.8 0.0 4.7e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Septin AAA_16 PF13191.6 CCF32236.1 - 3.4e-05 24.3 0.3 0.0005 20.5 0.0 2.2 1 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 CCF32236.1 - 0.00051 20.3 0.0 0.0022 18.3 0.0 2.1 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 CCF32236.1 - 0.0015 18.5 1.8 0.0035 17.2 0.4 2.3 2 1 0 2 2 2 1 RsgA GTPase Amidohydro_3 PF07969.11 CCF32236.1 - 0.002 17.7 0.0 0.63 9.4 0.0 2.1 1 1 1 2 2 2 2 Amidohydrolase family SRPRB PF09439.10 CCF32236.1 - 0.002 17.6 2.5 0.0037 16.7 0.0 2.3 2 1 0 2 2 2 1 Signal recognition particle receptor beta subunit Dynamin_N PF00350.23 CCF32236.1 - 0.0038 17.3 6.2 2.1 8.4 0.0 3.8 2 2 0 3 3 3 2 Dynamin family Viral_helicase1 PF01443.18 CCF32236.1 - 0.0082 15.9 0.0 0.17 11.6 0.0 2.2 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA_30 PF13604.6 CCF32236.1 - 0.024 14.4 0.0 0.069 12.9 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 CCF32236.1 - 0.039 14.1 1.1 0.59 10.3 0.3 2.7 2 1 0 2 2 2 0 AAA domain GBP PF02263.19 CCF32236.1 - 0.053 12.8 2.2 0.085 12.1 0.0 2.2 3 0 0 3 3 3 0 Guanylate-binding protein, N-terminal domain ABC_tran PF00005.27 CCF32236.1 - 0.053 14.0 0.7 0.53 10.8 0.0 2.3 2 1 0 2 2 2 0 ABC transporter DUF87 PF01935.17 CCF32236.1 - 0.45 10.6 5.7 0.84 9.7 0.1 3.0 1 1 1 2 2 2 0 Helicase HerA, central domain CENP-K PF11802.8 CCF32236.1 - 0.48 10.0 8.0 1.2 8.6 8.1 1.6 1 1 0 1 1 1 0 Centromere-associated protein K AAA_23 PF13476.6 CCF32236.1 - 0.49 10.9 9.4 25 5.3 0.0 2.5 2 1 0 2 2 2 0 AAA domain XPG_N PF00752.17 CCF32237.1 - 6.8e-05 23.3 0.0 0.0002 21.8 0.0 1.7 2 0 0 2 2 2 1 XPG N-terminal domain DNMT1-RFD PF12047.8 CCF32238.1 - 0.0013 18.8 0.0 0.0026 17.8 0.0 1.5 1 0 0 1 1 1 1 Cytosine specific DNA methyltransferase replication foci domain TruB_N PF01509.18 CCF32239.1 - 2.1e-45 154.7 0.0 5.9e-45 153.3 0.0 1.7 1 0 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 CCF32239.1 - 0.00014 22.0 0.0 0.00027 21.0 0.0 1.5 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain Arm_vescicular PF18770.1 CCF32239.1 - 0.13 12.2 0.0 0.38 10.7 0.0 1.7 2 0 0 2 2 2 0 Armadillo tether-repeat of vescicular transport factor VIR_N PF15912.5 CCF32239.1 - 8.7 5.8 10.6 0.34 10.5 2.3 2.2 2 0 0 2 2 2 0 Virilizer, N-terminal Sec2p PF06428.11 CCF32240.1 - 1.6e-12 47.2 8.5 1.7e-12 47.1 8.0 1.3 1 1 0 1 1 1 1 GDP/GTP exchange factor Sec2p Exonuc_VII_L PF02601.15 CCF32240.1 - 0.0077 15.8 3.2 0.0086 15.7 3.2 1.0 1 0 0 1 1 1 1 Exonuclease VII, large subunit Jnk-SapK_ap_N PF09744.9 CCF32240.1 - 0.11 12.7 9.2 0.14 12.4 9.2 1.2 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 HAUS-augmin3 PF14932.6 CCF32240.1 - 0.12 11.9 6.5 0.2 11.2 6.4 1.4 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 3 MbeD_MobD PF04899.12 CCF32240.1 - 0.32 11.1 7.7 1.9 8.6 6.7 2.1 1 1 1 2 2 2 0 MbeD/MobD like BST2 PF16716.5 CCF32240.1 - 0.96 10.1 8.1 1.3 9.6 7.5 1.5 1 1 0 1 1 1 0 Bone marrow stromal antigen 2 Lzipper-MIP1 PF14389.6 CCF32240.1 - 1 9.7 10.3 1.6 9.1 1.6 2.3 1 1 1 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 FUSC PF04632.12 CCF32240.1 - 2.3 6.7 10.4 2.6 6.5 10.4 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family Atg14 PF10186.9 CCF32240.1 - 3.1 6.8 9.0 3.5 6.6 9.0 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Fungal_trans PF04082.18 CCF32241.1 - 6.6e-19 68.0 0.1 1.1e-18 67.2 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 CCF32241.1 - 1.2e-08 34.9 13.4 0.00019 21.7 2.0 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CCF32241.1 - 1.1e-06 28.8 13.2 2.2e-06 27.8 7.1 3.1 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 CCF32241.1 - 0.00038 21.0 13.0 0.037 14.9 2.1 3.1 2 0 0 2 2 2 2 C2H2-type zinc finger C1_4 PF07975.12 CCF32241.1 - 0.34 11.2 2.1 0.89 9.8 2.1 1.7 1 0 0 1 1 1 0 TFIIH C1-like domain zf-C2H2_jaz PF12171.8 CCF32241.1 - 0.9 9.9 3.7 0.43 10.9 0.4 2.2 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CCF32241.1 - 2.6 8.6 5.2 0.63 10.5 1.1 2.1 2 0 0 2 2 2 0 Zinc-finger of C2H2 type TPR_19 PF14559.6 CCF32242.1 - 0.0021 18.5 0.7 0.074 13.6 0.4 2.8 1 1 1 2 2 2 1 Tetratricopeptide repeat NPV_P10 PF05531.12 CCF32242.1 - 0.004 17.6 2.1 0.0097 16.3 1.0 2.3 2 0 0 2 2 2 1 Nucleopolyhedrovirus P10 protein Big_3_3 PF13750.6 CCF32242.1 - 0.095 12.3 0.5 0.68 9.6 0.1 2.4 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 3) SesA PF17107.5 CCF32242.1 - 0.11 12.6 3.9 0.089 13.0 0.6 2.5 3 0 0 3 3 3 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Helo_like_N PF17111.5 CCF32242.1 - 0.16 11.3 5.5 0.41 10.0 5.5 1.7 1 1 0 1 1 1 0 Fungal N-terminal domain of STAND proteins FlaC_arch PF05377.11 CCF32242.1 - 0.27 11.7 1.2 1.9 9.0 1.1 2.5 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) SKA2 PF16740.5 CCF32242.1 - 0.43 10.4 4.9 0.49 10.2 1.0 3.0 3 0 0 3 3 3 0 Spindle and kinetochore-associated protein 2 Focal_AT PF03623.13 CCF32242.1 - 2.6 8.0 5.3 2.3 8.2 0.3 2.6 2 0 0 2 2 2 0 Focal adhesion targeting region NACHT PF05729.12 CCF32243.1 - 1.1e-12 48.2 0.4 2.6e-12 47.0 0.4 1.6 1 0 0 1 1 1 1 NACHT domain PNP_UDP_1 PF01048.20 CCF32243.1 - 8.9e-11 41.5 1.4 3.9e-10 39.4 1.4 2.0 1 1 0 1 1 1 1 Phosphorylase superfamily AAA_16 PF13191.6 CCF32243.1 - 6.5e-08 33.1 0.1 2.3e-07 31.3 0.1 1.9 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 CCF32243.1 - 2.5e-05 24.6 0.1 5.5e-05 23.5 0.1 1.5 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 CCF32243.1 - 2.6e-05 24.3 0.0 4.4e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea NB-ARC PF00931.22 CCF32243.1 - 0.00035 19.9 0.0 0.00072 18.8 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain AAA_33 PF13671.6 CCF32243.1 - 0.013 15.7 0.0 0.031 14.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain KAP_NTPase PF07693.14 CCF32243.1 - 0.055 12.7 0.3 9.7 5.3 0.0 2.2 1 1 1 2 2 2 0 KAP family P-loop domain APS_kinase PF01583.20 CCF32243.1 - 0.057 13.3 0.0 0.14 12.0 0.0 1.6 1 0 0 1 1 1 0 Adenylylsulphate kinase RNA_helicase PF00910.22 CCF32243.1 - 0.073 13.5 0.0 0.21 12.0 0.0 1.8 1 0 0 1 1 1 0 RNA helicase Synaptobrevin PF00957.21 CCF32244.1 - 7.2e-33 112.2 0.7 8.5e-33 112.0 0.7 1.0 1 0 0 1 1 1 1 Synaptobrevin AKNA PF12443.8 CCF32244.1 - 0.088 13.5 0.1 0.2 12.3 0.1 1.6 1 1 0 1 1 1 0 AT-hook-containing transcription factor AA_kinase PF00696.28 CCF32245.1 - 2e-30 106.2 0.0 2.8e-30 105.7 0.0 1.2 1 0 0 1 1 1 1 Amino acid kinase family NAT PF04768.13 CCF32245.1 - 1.4e-10 41.1 0.1 1.5e-09 37.7 0.0 2.3 2 0 0 2 2 2 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase Glyco_hydro_16 PF00722.21 CCF32246.1 - 3.8e-45 153.5 0.8 5.6e-45 153.0 0.8 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Topoisom_I PF01028.20 CCF32247.1 - 6.6e-97 323.3 7.2 1.7e-96 322.0 7.2 1.7 1 0 0 1 1 1 1 Eukaryotic DNA topoisomerase I, catalytic core Topoisom_I_N PF02919.15 CCF32247.1 - 3.4e-96 320.8 4.9 3.4e-96 320.8 4.9 2.8 4 0 0 4 4 4 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topo_C_assoc PF14370.6 CCF32247.1 - 1.3e-31 108.3 0.6 4.4e-31 106.6 0.6 2.0 1 0 0 1 1 1 1 C-terminal topoisomerase domain Csm1_N PF18504.1 CCF32247.1 - 0.0044 17.3 2.7 0.0044 17.3 2.7 2.8 2 0 0 2 2 2 1 Csm1 N-terminal domain ATP-synt PF00231.19 CCF32248.1 - 3.4e-58 197.6 0.2 3.9e-58 197.4 0.2 1.0 1 0 0 1 1 1 1 ATP synthase DUF5471 PF17565.2 CCF32248.1 - 0.0036 17.6 0.5 0.01 16.1 0.2 1.9 2 0 0 2 2 2 1 Family of unknown function (DUF5471) GNVR PF13807.6 CCF32248.1 - 0.081 12.9 0.0 2.3 8.2 0.0 2.6 3 0 0 3 3 3 0 G-rich domain on putative tyrosine kinase MFS_1 PF07690.16 CCF32249.1 - 2.4e-24 85.9 59.6 4.6e-18 65.3 48.2 3.3 1 1 1 2 2 2 2 Major Facilitator Superfamily AMP-binding PF00501.28 CCF32250.1 - 2e-76 257.3 0.1 2.7e-76 256.8 0.1 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CCF32250.1 - 7.4e-07 30.1 0.0 1.7e-06 28.9 0.0 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain DUF2568 PF10823.8 CCF32250.1 - 0.089 13.1 11.3 0.1 12.9 1.6 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2568) DUF5386 PF17360.2 CCF32250.1 - 0.19 11.6 0.0 0.33 10.8 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5386) adh_short PF00106.25 CCF32251.1 - 1.4e-23 83.4 0.0 1.9e-23 83.0 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF32251.1 - 1.4e-15 57.5 0.0 1.8e-15 57.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 CCF32251.1 - 4.5e-06 26.3 0.0 8.3e-06 25.4 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 CCF32251.1 - 0.00031 20.7 0.0 0.00049 20.0 0.0 1.4 1 1 0 1 1 1 1 KR domain Fungal_trans_2 PF11951.8 CCF32252.1 - 6.2e-20 71.4 3.0 1.2e-18 67.2 3.0 2.0 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF32252.1 - 1.1e-05 25.5 8.0 1.8e-05 24.7 8.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Peptidase_S8 PF00082.22 CCF32253.1 - 2.6e-20 72.9 16.5 3e-20 72.7 15.1 1.6 1 1 0 2 2 2 1 Subtilase family Inhibitor_I9 PF05922.16 CCF32253.1 - 2.4e-12 47.3 0.0 4.1e-12 46.6 0.0 1.4 1 0 0 1 1 1 1 Peptidase inhibitor I9 Pyr_redox_2 PF07992.14 CCF32254.1 - 2.1e-37 129.0 0.0 2.5e-37 128.7 0.0 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCF32254.1 - 1.7e-08 34.9 0.4 6.2e-08 33.1 0.1 2.0 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCF32254.1 - 0.029 14.6 0.0 10 6.4 0.0 3.1 3 0 0 3 3 3 0 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 CCF32254.1 - 0.035 13.2 0.2 0.53 9.3 0.0 2.5 3 0 0 3 3 3 0 FAD binding domain p450 PF00067.22 CCF32256.1 - 2.9e-30 105.4 0.0 2e-29 102.6 0.0 1.9 1 1 0 1 1 1 1 Cytochrome P450 DUF3328 PF11807.8 CCF32257.1 - 9.9e-13 48.4 4.5 1.9e-12 47.4 4.5 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF3328) ADH_zinc_N PF00107.26 CCF32258.1 - 1.2e-09 38.3 0.1 1.8e-09 37.7 0.1 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 CCF32258.1 - 2.4e-08 33.8 0.0 4e-08 33.1 0.0 1.3 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase UL45 PF05473.12 CCF32259.1 - 0.00012 21.8 0.0 0.00013 21.7 0.0 1.0 1 0 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like UreE_N PF02814.15 CCF32260.1 - 0.027 14.0 0.1 0.1 12.2 0.1 2.0 1 0 0 1 1 1 0 UreE urease accessory protein, N-terminal domain AAA_25 PF13481.6 CCF32260.1 - 0.075 12.6 0.2 0.27 10.8 0.0 2.0 2 1 0 2 2 2 0 AAA domain Macro PF01661.21 CCF32261.1 - 3.8e-24 85.0 0.0 7.8e-24 84.0 0.0 1.5 1 0 0 1 1 1 1 Macro domain PAP1 PF08601.10 CCF32261.1 - 0.16 11.6 0.3 0.27 10.9 0.3 1.2 1 0 0 1 1 1 0 Transcription factor PAP1 Fungal_trans PF04082.18 CCF32262.1 - 2.5e-08 33.3 0.1 1e-07 31.3 0.1 2.1 1 1 0 1 1 1 1 Fungal specific transcription factor domain SUIM_assoc PF16619.5 CCF32262.1 - 0.00034 20.6 0.6 0.00082 19.4 0.6 1.7 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CCF32262.1 - 0.0026 17.4 5.4 0.0042 16.7 5.4 1.2 1 0 0 1 1 1 1 Spt20 family TFIIA PF03153.13 CCF32262.1 - 4.1 7.3 9.9 0.38 10.7 4.9 1.7 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit HET PF06985.11 CCF32263.1 - 1.8e-24 86.7 2.3 2.7e-24 86.2 0.1 2.4 2 0 0 2 2 2 1 Heterokaryon incompatibility protein (HET) Lipase_GDSL_2 PF13472.6 CCF32264.1 - 1.8e-14 54.6 0.0 1.1e-12 48.7 0.0 2.4 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family fn3 PF00041.21 CCF32264.1 - 6.5e-09 36.0 4.6 0.0018 18.6 0.0 3.7 3 2 0 3 3 3 3 Fibronectin type III domain Lipase_GDSL PF00657.22 CCF32264.1 - 0.0028 17.7 0.0 0.033 14.2 0.0 2.1 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Pur_ac_phosph_N PF16656.5 CCF32264.1 - 0.0074 16.8 0.5 7.1 7.3 0.0 3.2 3 0 0 3 3 3 2 Purple acid Phosphatase, N-terminal domain PP2C PF00481.21 CCF32265.1 - 0.00048 19.9 0.0 0.00069 19.3 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C BTB PF00651.31 CCF32266.1 - 0.0028 17.9 0.1 2.2 8.5 0.1 2.9 2 0 0 2 2 2 2 BTB/POZ domain FTR1 PF03239.14 CCF32267.1 - 7.1e-82 275.0 8.5 8.5e-82 274.7 8.5 1.0 1 0 0 1 1 1 1 Iron permease FTR1 family Chs7 PF12271.8 CCF32267.1 - 0.17 11.2 3.6 0.12 11.7 1.5 1.6 1 1 0 1 1 1 0 Chitin synthase export chaperone Cu-oxidase_3 PF07732.15 CCF32268.1 - 1e-41 141.7 3.7 3.3e-41 140.0 0.9 2.7 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase PF00394.22 CCF32268.1 - 9.8e-41 139.5 1.6 1e-35 123.2 0.2 2.7 3 0 0 3 3 3 2 Multicopper oxidase Cu-oxidase_2 PF07731.14 CCF32268.1 - 1.8e-27 95.8 2.6 1.8e-21 76.3 0.0 3.2 3 1 0 3 3 3 2 Multicopper oxidase Cupredoxin_1 PF13473.6 CCF32268.1 - 0.016 15.3 0.0 2 8.5 0.0 3.1 3 1 0 3 3 3 0 Cupredoxin-like domain DUF2196 PF09962.9 CCF32271.1 - 6.8e-23 80.4 4.2 1.2e-22 79.6 4.2 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2196) TOBE_2 PF08402.10 CCF32271.1 - 0.014 15.5 1.6 0.028 14.6 1.6 1.6 1 0 0 1 1 1 0 TOBE domain SSrecog PF03531.14 CCF32272.1 - 2.6e-31 107.3 0.2 1.7e-30 104.7 0.0 2.5 2 0 0 2 2 2 1 Structure-specific recognition protein (SSRP1) POB3_N PF17292.2 CCF32272.1 - 3.1e-31 107.7 0.3 7.2e-30 103.3 0.1 2.7 3 0 0 3 3 3 1 POB3-like N-terminal PH domain Rtt106 PF08512.12 CCF32272.1 - 1.1e-22 80.3 0.1 1.3e-21 76.8 0.0 2.6 3 0 0 3 3 3 1 Histone chaperone Rttp106-like YL1 PF05764.13 CCF32272.1 - 4.1 7.4 22.0 9.8 6.2 22.0 1.7 1 0 0 1 1 1 0 YL1 nuclear protein AMP-binding PF00501.28 CCF32273.1 - 1e-72 245.1 0.0 1.2e-72 244.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CCF32273.1 - 1.2e-19 71.0 0.0 2.7e-19 69.9 0.0 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Ifi-6-16 PF06140.13 CCF32273.1 - 0.089 12.7 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Interferon-induced 6-16 family LysR_substrate PF03466.20 CCF32273.1 - 0.16 11.3 0.0 0.44 9.9 0.0 1.7 2 0 0 2 2 2 0 LysR substrate binding domain Glyco_hydro_76 PF03663.14 CCF32275.1 - 3.4e-22 79.5 4.0 6.1e-20 72.1 4.0 3.1 1 1 0 1 1 1 1 Glycosyl hydrolase family 76 Spt20 PF12090.8 CCF32276.1 - 0.033 13.8 3.6 0.042 13.4 3.6 1.2 1 0 0 1 1 1 0 Spt20 family SARAF PF06682.12 CCF32276.1 - 0.15 11.7 9.0 0.13 11.8 7.2 1.6 1 1 1 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis Ribophorin_II PF05817.14 CCF32277.1 - 4.4e-35 121.4 0.0 5.2e-35 121.1 0.0 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit Ribophorin II Peptidase_M28 PF04389.17 CCF32278.1 - 6.4e-23 81.5 0.0 8.6e-23 81.1 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M28 GTP_EFTU_D2 PF03144.25 CCF32279.1 - 0.14 12.5 0.1 2 8.9 0.0 2.6 2 0 0 2 2 2 0 Elongation factor Tu domain 2 DUF5546 PF17700.1 CCF32279.1 - 0.15 12.4 0.1 0.38 11.1 0.1 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5546) Rab5ip PF07019.12 CCF32280.1 - 2.1e-29 101.9 8.2 2.5e-29 101.7 8.2 1.1 1 0 0 1 1 1 1 Rab5-interacting protein (Rab5ip) RL11D PF11088.8 CCF32280.1 - 0.18 12.1 0.0 0.26 11.6 0.0 1.3 1 0 0 1 1 1 0 Glycoprotein encoding membrane proteins RL5A and RL6 Vezatin PF12632.7 CCF32281.1 - 7.9e-79 264.9 0.0 1.3e-78 264.2 0.0 1.3 1 0 0 1 1 1 1 Mysoin-binding motif of peroxisomes DUF4231 PF14015.6 CCF32281.1 - 0.014 15.9 2.2 0.32 11.5 1.4 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) DUF4381 PF14316.6 CCF32281.1 - 0.22 11.7 1.4 0.75 10.0 1.4 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) REV PF00424.18 CCF32281.1 - 1.8 8.6 5.6 0.77 9.8 0.2 2.9 3 0 0 3 3 3 0 REV protein (anti-repression trans-activator protein) PCNA_N PF00705.18 CCF32282.1 - 1.6e-54 183.0 4.5 4.5e-54 181.6 3.2 2.0 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.15 CCF32282.1 - 2.6e-48 163.4 0.1 4.7e-48 162.6 0.1 1.4 1 0 0 1 1 1 1 Proliferating cell nuclear antigen, C-terminal domain Rad9 PF04139.13 CCF32282.1 - 5.7e-09 35.8 0.1 7.3e-09 35.4 0.1 1.1 1 0 0 1 1 1 1 Rad9 Rad1 PF02144.16 CCF32282.1 - 1.2e-06 27.8 0.5 5.3e-05 22.4 0.5 2.0 1 1 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 Hus1 PF04005.12 CCF32282.1 - 3.1e-05 23.2 0.1 0.0015 17.7 0.0 2.1 2 0 0 2 2 2 1 Hus1-like protein DNA_pol3_beta_3 PF02768.15 CCF32282.1 - 0.061 13.2 0.1 0.25 11.2 0.0 2.1 2 0 0 2 2 2 0 DNA polymerase III beta subunit, C-terminal domain Phos_pyr_kin PF08543.12 CCF32283.1 - 5.5e-08 32.5 0.0 7e-08 32.2 0.0 1.2 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.24 CCF32283.1 - 0.00018 21.0 0.1 0.00041 19.7 0.0 1.6 2 0 0 2 2 2 1 pfkB family carbohydrate kinase Leader_CPA1 PF08252.11 CCF32284.1 - 1.1e-14 53.5 0.2 2e-14 52.6 0.0 1.5 2 0 0 2 2 2 1 arg-2/CPA1 leader peptide GATase PF00117.28 CCF32285.1 - 8e-48 162.7 0.0 1.1e-47 162.3 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I CPSase_sm_chain PF00988.22 CCF32285.1 - 4.8e-46 155.8 0.0 7.2e-46 155.2 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain Peptidase_C26 PF07722.13 CCF32285.1 - 2.8e-05 24.0 0.2 0.0023 17.7 0.2 2.7 1 1 0 1 1 1 1 Peptidase C26 DJ-1_PfpI PF01965.24 CCF32285.1 - 0.18 11.6 0.0 0.32 10.8 0.0 1.4 1 0 0 1 1 1 0 DJ-1/PfpI family SAP PF02037.27 CCF32286.1 - 1.5e-11 43.8 0.4 3.1e-11 42.8 0.4 1.6 1 0 0 1 1 1 1 SAP domain DUF1103 PF06513.11 CCF32286.1 - 0.081 12.5 1.9 0.17 11.5 1.9 1.5 1 0 0 1 1 1 0 Repeat of unknown function (DUF1103) DUF719 PF05334.13 CCF32286.1 - 0.4 10.9 5.6 0.16 12.2 2.0 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF719) TPT PF03151.16 CCF32288.1 - 2.2e-23 83.0 15.2 2.7e-23 82.7 15.2 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family UAA PF08449.11 CCF32288.1 - 0.19 10.9 18.2 0.31 10.2 18.2 1.3 1 1 0 1 1 1 0 UAA transporter family EamA PF00892.20 CCF32288.1 - 0.51 10.5 31.1 0.14 12.3 13.6 2.8 3 0 0 3 3 3 0 EamA-like transporter family TENA_THI-4 PF03070.16 CCF32289.1 - 1e-05 25.4 0.0 0.0054 16.6 0.0 2.2 2 0 0 2 2 2 2 TENA/THI-4/PQQC family UCH PF00443.29 CCF32290.1 - 6.2e-37 127.5 0.0 1.1e-36 126.7 0.0 1.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CCF32290.1 - 1.9e-07 31.0 0.1 1.2e-06 28.4 0.1 2.1 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Alb1 PF09135.11 CCF32291.1 - 2e-30 105.7 19.8 2e-30 105.7 19.8 1.6 2 0 0 2 2 2 1 Alb1 MCM3AP_GANP PF16769.5 CCF32291.1 - 0.32 9.2 7.4 0.33 9.1 7.4 1.0 1 0 0 1 1 1 0 MCM3AP domain of GANP DUF4570 PF15134.6 CCF32291.1 - 0.34 10.9 7.5 0.22 11.6 4.7 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4570) V_ATPase_I PF01496.19 CCF32291.1 - 4.7 5.0 5.7 5.4 4.8 5.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family LysM PF01476.20 CCF32292.1 - 0.0065 16.5 0.1 0.021 14.9 0.0 1.8 2 0 0 2 2 2 1 LysM domain His_Phos_1 PF00300.22 CCF32293.1 - 3e-09 36.9 0.0 7.6e-09 35.5 0.0 1.7 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) CTP_transf_like PF01467.26 CCF32294.1 - 1.2e-26 93.6 0.0 3.8e-22 79.0 0.0 3.2 2 1 0 3 3 3 3 Cytidylyltransferase-like FAD_syn PF06574.12 CCF32294.1 - 0.23 11.4 0.3 26 4.7 0.1 3.0 3 0 0 3 3 3 0 FAD synthetase Aminotran_4 PF01063.19 CCF32295.1 - 2.2e-22 80.0 0.0 3e-22 79.6 0.0 1.2 1 0 0 1 1 1 1 Amino-transferase class IV DEK_C PF08766.11 CCF32295.1 - 0.18 11.8 0.0 0.39 10.7 0.0 1.5 1 0 0 1 1 1 0 DEK C terminal domain DUF4818 PF16089.5 CCF32297.1 - 0.47 10.9 11.1 0.9 10.0 0.2 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4818) MFS_1 PF07690.16 CCF32297.1 - 5 5.9 15.1 0.11 11.4 3.8 2.1 1 1 1 2 2 2 0 Major Facilitator Superfamily SUR7 PF06687.12 CCF32297.1 - 5.4 6.6 16.2 0.51 9.9 3.1 2.3 2 1 0 2 2 2 0 SUR7/PalI family NOA36 PF06524.12 CCF32298.1 - 1.1 8.5 4.1 1.6 8.0 4.1 1.2 1 0 0 1 1 1 0 NOA36 protein Cwf_Cwc_15 PF04889.12 CCF32298.1 - 1.3 8.7 6.1 1.8 8.2 6.1 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein PBP1_TM PF14812.6 CCF32298.1 - 6.8 7.1 11.0 1.7 9.1 7.1 1.9 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Peptidase_M49 PF03571.15 CCF32300.1 - 7.2e-249 826.8 0.0 9.1e-249 826.4 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M49 2C_adapt PF08793.10 CCF32300.1 - 0.31 11.3 0.8 0.87 9.8 0.8 1.7 1 0 0 1 1 1 0 2-cysteine adaptor domain Ribosomal_L6e PF01159.19 CCF32301.1 - 1.2e-40 138.5 0.4 2.1e-40 137.7 0.4 1.4 1 0 0 1 1 1 1 Ribosomal protein L6e AAA_lid_9 PF17871.1 CCF32302.1 - 2.5e-35 120.5 3.4 2.5e-35 120.5 3.4 2.5 2 0 0 2 2 2 1 AAA lid domain AAA_2 PF07724.14 CCF32302.1 - 1.6e-32 113.0 0.0 5.3e-30 104.8 0.0 3.3 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) ClpB_D2-small PF10431.9 CCF32302.1 - 5e-16 58.5 0.0 2e-15 56.6 0.0 2.1 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.29 CCF32302.1 - 7.2e-15 55.6 0.1 1.6e-09 38.3 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CCF32302.1 - 1.7e-09 38.3 1.5 0.0014 19.0 0.1 3.4 2 1 1 3 3 3 2 AAA ATPase domain TniB PF05621.11 CCF32302.1 - 2.4e-06 27.1 0.1 0.00091 18.7 0.1 3.2 2 1 0 2 2 2 1 Bacterial TniB protein AAA_22 PF13401.6 CCF32302.1 - 6.7e-06 26.4 2.6 0.052 13.8 0.1 3.3 3 1 0 3 3 3 2 AAA domain ATPase_2 PF01637.18 CCF32302.1 - 2.3e-05 24.4 5.9 0.72 9.7 0.1 4.2 3 1 0 4 4 4 2 ATPase domain predominantly from Archaea AAA_5 PF07728.14 CCF32302.1 - 0.0001 22.3 0.1 0.2 11.7 0.0 3.1 4 0 0 4 4 2 1 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 CCF32302.1 - 0.00021 20.9 0.0 0.7 9.4 0.0 2.6 2 0 0 2 2 2 2 P-loop containing dynein motor region IstB_IS21 PF01695.17 CCF32302.1 - 0.00042 20.1 0.0 0.42 10.3 0.0 2.5 2 0 0 2 2 2 1 IstB-like ATP binding protein NACHT PF05729.12 CCF32302.1 - 0.00049 20.1 0.3 0.081 12.8 0.1 2.5 2 1 0 2 2 2 1 NACHT domain AAA_18 PF13238.6 CCF32302.1 - 0.0005 20.6 0.1 0.39 11.3 0.0 3.0 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 CCF32302.1 - 0.00099 19.2 0.0 0.39 10.7 0.0 2.6 2 0 0 2 2 2 1 AAA domain Sigma54_activat PF00158.26 CCF32302.1 - 0.0017 18.1 0.3 1.9 8.1 0.0 2.6 2 1 0 2 2 2 2 Sigma-54 interaction domain ABC_tran PF00005.27 CCF32302.1 - 0.002 18.6 2.0 0.48 10.9 0.0 3.4 3 0 0 3 3 3 1 ABC transporter AAA_23 PF13476.6 CCF32302.1 - 0.0027 18.2 8.2 1.4 9.4 4.7 3.2 3 0 0 3 3 3 1 AAA domain AAA_33 PF13671.6 CCF32302.1 - 0.0045 17.2 0.0 2 8.6 0.0 2.7 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 CCF32302.1 - 0.0053 16.7 0.2 1.2 9.0 0.0 2.9 2 1 0 2 2 2 1 RsgA GTPase AAA_30 PF13604.6 CCF32302.1 - 0.0068 16.1 0.1 0.34 10.6 0.0 3.1 3 0 0 3 3 3 1 AAA domain RNA_helicase PF00910.22 CCF32302.1 - 0.0085 16.5 0.0 1.4 9.4 0.0 2.7 2 0 0 2 2 2 1 RNA helicase PhoH PF02562.16 CCF32302.1 - 0.011 15.3 0.1 0.26 10.7 0.0 2.4 2 0 0 2 2 2 0 PhoH-like protein AAA_28 PF13521.6 CCF32302.1 - 0.015 15.6 0.6 12 6.1 0.0 3.3 3 1 0 3 3 3 0 AAA domain AAA_24 PF13479.6 CCF32302.1 - 0.016 14.9 0.1 8.1 6.1 0.0 2.6 2 0 0 2 2 2 0 AAA domain ResIII PF04851.15 CCF32302.1 - 0.018 15.1 0.2 10 6.1 0.0 3.3 2 1 0 3 3 3 0 Type III restriction enzyme, res subunit AAA_25 PF13481.6 CCF32302.1 - 0.02 14.5 0.2 0.28 10.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain SRP54 PF00448.22 CCF32302.1 - 0.02 14.5 0.1 0.57 9.8 0.0 2.4 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain Roc PF08477.13 CCF32302.1 - 0.027 14.7 0.1 3.1 8.1 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase PduV-EutP PF10662.9 CCF32302.1 - 0.035 13.9 0.0 0.79 9.5 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Mg_chelatase PF01078.21 CCF32302.1 - 0.073 12.4 0.0 2.7 7.3 0.0 2.4 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI TsaE PF02367.17 CCF32302.1 - 0.079 13.0 0.1 8.8 6.4 0.0 2.6 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_19 PF13245.6 CCF32302.1 - 0.096 13.0 0.6 1.2 9.5 0.3 2.5 2 1 0 2 2 2 0 AAA domain UvrD-helicase PF00580.21 CCF32302.1 - 0.11 12.0 4.1 0.22 11.0 0.1 2.2 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain PIF1 PF05970.14 CCF32302.1 - 0.13 11.4 0.0 5.1 6.2 0.0 2.3 2 0 0 2 2 2 0 PIF1-like helicase ATP_bind_1 PF03029.17 CCF32302.1 - 0.15 11.8 0.1 2.5 7.8 0.0 2.3 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein DUF4407 PF14362.6 CCF32302.1 - 0.17 11.2 2.8 0.25 10.6 2.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) AAA_15 PF13175.6 CCF32302.1 - 0.36 10.5 3.3 7 6.3 0.9 2.3 2 0 0 2 2 2 0 AAA ATPase domain T3SSipB PF16535.5 CCF32302.1 - 0.47 10.9 5.9 1.4 9.3 5.9 1.9 1 0 0 1 1 1 0 Type III cell invasion protein SipB DUF3584 PF12128.8 CCF32302.1 - 0.62 7.5 9.9 1 6.8 9.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) UPF0242 PF06785.11 CCF32302.1 - 1.3 9.1 10.5 2.5 8.2 10.5 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Seryl_tRNA_N PF02403.22 CCF32302.1 - 1.5 9.1 16.1 2.8 8.2 11.9 3.0 3 1 0 3 3 1 0 Seryl-tRNA synthetase N-terminal domain DUF16 PF01519.16 CCF32302.1 - 1.7 9.2 6.7 37 4.9 4.5 3.1 3 1 0 3 3 2 0 Protein of unknown function DUF16 GrpE PF01025.19 CCF32302.1 - 1.8 8.2 9.4 1.8 8.2 7.9 1.9 2 0 0 2 2 1 0 GrpE CENP-F_leu_zip PF10473.9 CCF32302.1 - 3.3 7.7 16.9 1.6 8.7 14.0 1.9 2 1 0 2 2 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 zf-C4H2 PF10146.9 CCF32302.1 - 3.8 7.7 6.5 8.8 6.6 6.5 1.5 1 0 0 1 1 1 0 Zinc finger-containing protein DUF4337 PF14235.6 CCF32302.1 - 7.3 6.7 6.1 13 5.9 6.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) Ribosomal_L28e PF01778.17 CCF32303.1 - 1.6e-14 54.6 0.2 2e-14 54.3 0.2 1.1 1 0 0 1 1 1 1 Ribosomal L28e protein family DUF2015 PF09435.10 CCF32305.1 - 8.6e-48 160.8 0.0 9.9e-48 160.7 0.0 1.0 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF2015) FA_hydroxylase PF04116.13 CCF32306.1 - 3.1e-24 85.8 21.0 4.8e-24 85.2 15.5 2.2 2 0 0 2 2 2 2 Fatty acid hydroxylase superfamily Acyltransferase PF01553.21 CCF32307.1 - 4.2e-27 94.4 0.0 6.1e-27 93.9 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 CCF32307.1 - 1.5e-13 50.6 0.1 2.9e-13 49.7 0.1 1.4 1 0 0 1 1 1 1 Acyltransferase C-terminus LCCL PF03815.19 CCF32309.1 - 2.9e-19 69.0 0.1 4.5e-19 68.4 0.1 1.2 1 0 0 1 1 1 1 LCCL domain Peptidase_U4 PF03419.13 CCF32309.1 - 0.63 9.3 7.2 1.2 8.3 7.2 1.5 1 0 0 1 1 1 0 Sporulation factor SpoIIGA AMP-binding PF00501.28 CCF32310.1 - 2.9e-75 253.5 0.0 4.7e-75 252.8 0.0 1.4 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.12 CCF32310.1 - 5e-59 199.6 0.0 1e-58 198.5 0.0 1.6 1 0 0 1 1 1 1 Male sterility protein adh_short PF00106.25 CCF32310.1 - 8e-52 175.5 2.7 8e-52 175.5 2.7 1.9 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF32310.1 - 8.4e-40 136.8 1.6 2e-39 135.6 1.6 1.6 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF32310.1 - 1.3e-20 74.1 2.4 2.4e-15 56.9 1.2 2.4 2 0 0 2 2 2 2 KR domain Epimerase PF01370.21 CCF32310.1 - 1.8e-14 53.8 0.8 3.6e-08 33.2 0.0 3.6 3 2 0 3 3 3 2 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 CCF32310.1 - 2.1e-11 44.0 0.0 5.9e-11 42.6 0.0 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site NAD_binding_10 PF13460.6 CCF32310.1 - 5.4e-07 29.7 0.3 6.5e-05 22.9 0.5 2.7 2 0 0 2 2 2 1 NAD(P)H-binding 3Beta_HSD PF01073.19 CCF32310.1 - 2.5e-06 26.7 0.2 0.00019 20.5 0.0 2.9 2 1 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 CCF32310.1 - 2.4e-05 23.6 1.8 0.1 11.7 0.2 3.3 3 1 0 3 3 3 2 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 CCF32310.1 - 0.00011 21.5 2.6 0.014 14.5 0.1 3.6 3 1 0 3 3 3 1 RmlD substrate binding domain AMP-binding_C PF13193.6 CCF32310.1 - 0.00073 20.5 0.3 0.0058 17.6 0.1 2.8 3 0 0 3 3 2 1 AMP-binding enzyme C-terminal domain THF_DHG_CYH_C PF02882.19 CCF32310.1 - 0.018 14.4 0.3 0.045 13.1 0.3 1.7 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DFP PF04127.15 CCF32310.1 - 0.021 14.7 1.5 0.049 13.5 1.5 1.5 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein GDP_Man_Dehyd PF16363.5 CCF32310.1 - 0.033 13.6 0.1 8.6 5.6 0.0 2.4 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase NmrA PF05368.13 CCF32310.1 - 0.037 13.6 3.6 7.5 6.0 2.5 2.7 3 0 0 3 3 3 0 NmrA-like family TGT PF01702.18 CCF32311.1 - 2.7e-15 56.4 0.0 3.5e-15 56.0 0.0 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase RNA_pol_Rpb1_5 PF04998.17 CCF32312.1 - 4.1e-102 341.2 0.0 5.7e-102 340.7 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_6 PF04992.14 CCF32312.1 - 5.6e-62 209.0 5.3 9.5e-62 208.2 5.3 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_7 PF04990.12 CCF32312.1 - 5.7e-48 162.3 5.5 1.9e-47 160.7 5.3 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 7 RNA_pol_Rpb1_4 PF05000.17 CCF32312.1 - 3e-37 126.9 0.1 6.8e-37 125.7 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_3 PF04983.18 CCF32312.1 - 3e-26 92.2 0.0 9.3e-26 90.6 0.0 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 DIRP PF06584.13 CCF32312.1 - 0.22 11.7 0.5 0.62 10.3 0.5 1.7 1 0 0 1 1 1 0 DIRP PRK PF00485.18 CCF32313.1 - 2.7e-56 190.4 0.0 3.8e-56 190.0 0.0 1.2 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family UPRTase PF14681.6 CCF32313.1 - 8.7e-42 142.9 0.0 1.3e-41 142.3 0.0 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase AAA_18 PF13238.6 CCF32313.1 - 5e-06 27.1 0.0 1.2e-05 25.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 CCF32313.1 - 3.6e-05 23.9 0.0 0.00026 21.2 0.0 2.3 1 1 0 1 1 1 1 AAA domain CPT PF07931.12 CCF32313.1 - 7e-05 22.7 0.0 0.00014 21.8 0.0 1.5 1 0 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein AAA_17 PF13207.6 CCF32313.1 - 0.00084 19.8 0.1 0.54 10.7 0.0 2.6 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 CCF32313.1 - 0.0031 18.0 0.2 0.0093 16.5 0.1 1.7 2 0 0 2 2 2 1 ABC transporter Zeta_toxin PF06414.12 CCF32313.1 - 0.0058 15.9 0.0 0.013 14.8 0.0 1.6 1 0 0 1 1 1 1 Zeta toxin AAA_29 PF13555.6 CCF32313.1 - 0.023 14.4 0.1 0.055 13.2 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain NB-ARC PF00931.22 CCF32313.1 - 0.03 13.5 0.0 0.055 12.6 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain DUF87 PF01935.17 CCF32313.1 - 0.069 13.2 0.0 0.14 12.2 0.0 1.6 1 0 0 1 1 1 0 Helicase HerA, central domain Cytidylate_kin PF02224.18 CCF32313.1 - 0.077 12.7 0.1 0.22 11.2 0.0 1.8 2 0 0 2 2 2 0 Cytidylate kinase dNK PF01712.19 CCF32313.1 - 0.082 12.8 0.0 7.9 6.3 0.0 2.4 2 1 0 2 2 2 0 Deoxynucleoside kinase Phasin_2 PF09361.10 CCF32313.1 - 0.16 12.3 0.0 0.34 11.2 0.0 1.5 1 0 0 1 1 1 0 Phasin protein APS_kinase PF01583.20 CCF32313.1 - 0.16 11.8 0.0 0.41 10.5 0.0 1.7 1 0 0 1 1 1 0 Adenylylsulphate kinase CLTH PF10607.9 CCF32315.1 - 1.9e-31 109.0 0.0 2.6e-31 108.5 0.0 1.2 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 CCF32315.1 - 4.9e-09 35.8 0.0 9.1e-09 35.0 0.0 1.5 1 0 0 1 1 1 1 LisH Ribosomal_S8 PF00410.19 CCF32315.1 - 0.093 12.7 0.2 0.19 11.6 0.1 1.5 2 0 0 2 2 2 0 Ribosomal protein S8 ETC_C1_NDUFA4 PF04800.12 CCF32316.1 - 6.7e-37 125.6 1.4 1e-36 125.0 1.4 1.3 1 0 0 1 1 1 1 ETC complex I subunit conserved region Copper-bind PF00127.20 CCF32316.1 - 0.058 13.8 0.0 0.12 12.8 0.0 1.5 1 1 0 1 1 1 0 Copper binding proteins, plastocyanin/azurin family F1F0-ATPsyn_F PF10791.9 CCF32317.1 - 2.6e-41 140.0 0.1 2.9e-41 139.8 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial F1-F0 ATP synthase subunit F of fungi WRW PF10206.9 CCF32317.1 - 0.032 14.6 0.0 0.036 14.4 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial F1F0-ATP synthase, subunit f PIP5K PF01504.18 CCF32326.1 - 1.9e-46 158.5 0.0 1.9e-45 155.2 0.0 1.9 1 1 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Acetyltransf_1 PF00583.25 CCF32327.1 - 2.2e-07 31.1 0.0 3.4e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CCF32327.1 - 1.5e-05 24.9 0.0 3.5e-05 23.7 0.0 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CCF32327.1 - 0.0002 21.7 0.0 0.00057 20.3 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Glyco_trans_4_4 PF13579.6 CCF32327.1 - 0.039 14.4 0.9 0.08 13.4 0.7 1.5 1 1 0 1 1 1 0 Glycosyl transferase 4-like domain SUR7 PF06687.12 CCF32328.1 - 4.3e-16 59.2 1.5 5.2e-16 58.9 1.5 1.1 1 0 0 1 1 1 1 SUR7/PalI family Lactamase_B_2 PF12706.7 CCF32334.1 - 8.3e-28 97.3 0.0 3.9e-26 91.8 0.0 2.4 2 1 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 CCF32334.1 - 4.3e-09 36.5 0.0 6.2e-09 36.0 0.0 1.4 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 CCF32334.1 - 0.032 14.2 2.7 0.16 11.9 2.6 2.2 1 1 0 1 1 1 0 Metallo-beta-lactamase superfamily Promethin PF16015.5 CCF32337.1 - 1.6e-34 118.0 16.7 2e-34 117.7 16.7 1.1 1 0 0 1 1 1 1 Promethin YlaC PF10777.9 CCF32337.1 - 0.5 10.2 3.1 0.82 9.5 2.9 1.4 1 1 0 1 1 1 0 Inner membrane protein YlaC DUF2070 PF09843.9 CCF32337.1 - 2.3 6.4 9.0 2.6 6.3 9.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) TRAM_LAG1_CLN8 PF03798.16 CCF32338.1 - 3.2e-39 134.7 11.2 5.5e-39 134.0 11.2 1.4 1 0 0 1 1 1 1 TLC domain TRAM1 PF08390.11 CCF32338.1 - 1.3e-19 69.6 0.0 1.3e-19 69.6 0.0 1.9 2 0 0 2 2 2 1 TRAM1-like protein Calmodulin_bind PF07887.11 CCF32338.1 - 0.15 11.3 0.1 0.23 10.7 0.1 1.2 1 0 0 1 1 1 0 Calmodulin binding protein-like Tubulin PF00091.25 CCF32339.1 - 2.6e-58 197.5 0.0 8.7e-58 195.8 0.0 1.7 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 CCF32339.1 - 1.4e-38 131.9 0.1 2.2e-38 131.2 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 CCF32339.1 - 0.0013 18.4 0.0 0.0025 17.5 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.6 CCF32339.1 - 0.0095 15.2 0.0 0.017 14.3 0.0 1.4 1 0 0 1 1 1 1 Tubulin like DnaJ PF00226.31 CCF32340.1 - 3.3e-14 52.7 2.8 1.4e-13 50.8 0.7 2.5 2 0 0 2 2 2 1 DnaJ domain WDCP PF15390.6 CCF32340.1 - 1.7 7.0 3.7 2.1 6.6 3.7 1.2 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family GCV_T PF01571.21 CCF32341.1 - 1.9e-06 27.4 0.0 3.4e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain Kelch_5 PF13854.6 CCF32342.1 - 3.8e-08 33.1 4.3 3.1e-07 30.2 0.0 3.7 4 0 0 4 4 4 1 Kelch motif SKG6 PF08693.10 CCF32342.1 - 4e-07 29.3 1.1 7.3e-07 28.5 1.1 1.5 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Kelch_3 PF13415.6 CCF32342.1 - 9.6e-07 28.9 2.1 0.021 15.1 0.2 4.2 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_1 PF01344.25 CCF32342.1 - 0.00022 20.7 0.3 0.14 11.8 0.1 3.8 3 0 0 3 3 3 1 Kelch motif Kelch_6 PF13964.6 CCF32342.1 - 0.0027 17.9 5.4 0.46 10.9 0.3 4.3 5 1 1 6 6 6 2 Kelch motif Kelch_2 PF07646.15 CCF32342.1 - 0.016 15.2 4.0 3.3 7.8 0.9 4.1 4 2 0 4 4 4 0 Kelch motif Kelch_4 PF13418.6 CCF32342.1 - 0.095 12.7 8.4 3.3 7.8 0.0 4.8 5 0 0 5 5 5 0 Galactose oxidase, central domain Adeno_E3_CR2 PF02439.15 CCF32342.1 - 0.3 10.9 1.4 0.58 10.0 1.4 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 SMC_N PF02463.19 CCF32343.1 - 9.3e-67 224.7 0.0 1.6e-66 223.9 0.0 1.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 CCF32343.1 - 5.9e-27 94.3 0.0 2.3e-26 92.4 0.0 2.1 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 CCF32343.1 - 1e-14 55.1 13.3 9.1e-09 35.5 0.7 4.0 4 1 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 CCF32343.1 - 4.7e-10 39.7 63.0 4.8e-09 36.4 24.0 4.8 2 2 0 2 2 2 1 AAA ATPase domain AAA_23 PF13476.6 CCF32343.1 - 0.00015 22.3 56.4 0.00015 22.3 56.4 7.9 2 2 2 4 4 2 1 AAA domain SbcCD_C PF13558.6 CCF32343.1 - 0.00029 21.0 0.6 0.0013 18.9 0.0 2.5 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit BRE1 PF08647.11 CCF32343.1 - 0.00085 19.3 6.5 0.00085 19.3 6.5 8.7 5 2 2 8 8 8 2 BRE1 E3 ubiquitin ligase AAA_29 PF13555.6 CCF32343.1 - 0.0034 17.1 0.0 0.0085 15.8 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain APG6_N PF17675.1 CCF32343.1 - 0.0057 17.2 15.3 0.0057 17.2 15.3 8.7 2 2 6 8 8 8 2 Apg6 coiled-coil region Laminin_II PF06009.12 CCF32343.1 - 0.015 15.3 2.1 0.015 15.3 2.1 8.4 4 2 4 9 9 9 0 Laminin Domain II HlyD_3 PF13437.6 CCF32343.1 - 0.25 12.1 3.8 0.24 12.1 1.2 2.4 2 0 0 2 2 2 0 HlyD family secretion protein ABC_tran PF00005.27 CCF32343.1 - 0.28 11.7 0.0 0.28 11.7 0.0 6.6 4 2 0 4 4 2 0 ABC transporter DEAD PF00270.29 CCF32343.1 - 0.74 9.6 5.0 2 8.1 0.0 3.5 3 1 0 3 3 3 0 DEAD/DEAH box helicase Complex1_LYR_2 PF13233.6 CCF32344.1 - 1.4e-16 61.0 0.0 1.9e-16 60.6 0.0 1.2 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.15 CCF32344.1 - 1.7e-08 34.3 0.2 3.9e-08 33.2 0.1 1.6 2 0 0 2 2 2 1 Complex 1 protein (LYR family) HA2 PF04408.23 CCF32345.1 - 5.6e-17 62.0 1.4 1.1e-16 61.0 0.0 2.2 3 0 0 3 3 3 1 Helicase associated domain (HA2) Helicase_C PF00271.31 CCF32345.1 - 3.8e-11 43.3 0.1 1.4e-10 41.5 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 CCF32345.1 - 1.2e-10 41.6 0.1 4.7e-10 39.7 0.1 2.0 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 CCF32345.1 - 2.2e-07 30.8 0.0 5.8e-07 29.4 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 CCF32345.1 - 0.00067 19.9 0.0 0.0019 18.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CCF32345.1 - 0.0075 16.0 0.0 0.018 14.8 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.27 CCF32345.1 - 0.027 15.0 0.0 0.13 12.8 0.0 2.2 2 0 0 2 2 2 0 ABC transporter T2SSE PF00437.20 CCF32345.1 - 0.068 12.2 0.0 0.13 11.3 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein Clostridium_P47 PF06597.11 CCF32345.1 - 0.07 11.9 0.0 0.15 10.8 0.0 1.4 1 0 0 1 1 1 0 Clostridium P-47 protein AAA_16 PF13191.6 CCF32345.1 - 0.11 12.8 0.1 0.41 11.0 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain AAA_23 PF13476.6 CCF32345.1 - 1 9.8 5.5 4.1 7.8 0.0 3.1 3 0 0 3 3 3 0 AAA domain NAPRTase_C PF17956.1 CCF32346.1 - 0.081 13.4 0.0 0.17 12.3 0.0 1.5 1 0 0 1 1 1 0 Nicotinate phosphoribosyltransferase C-terminal domain Usp PF00582.26 CCF32347.1 - 9.9 6.7 7.8 0.98 9.9 1.2 2.4 1 1 1 2 2 2 0 Universal stress protein family CAP_GLY PF01302.25 CCF32349.1 - 3.5e-17 62.2 0.4 4.7e-17 61.8 0.4 1.2 1 0 0 1 1 1 1 CAP-Gly domain Nop14 PF04147.12 CCF32351.1 - 1.1e-295 983.4 37.7 1.5e-295 983.0 37.7 1.1 1 0 0 1 1 1 1 Nop14-like family G-patch PF01585.23 CCF32352.1 - 4.4e-07 29.7 4.7 9e-07 28.7 4.7 1.6 1 0 0 1 1 1 1 G-patch domain RRP14 PF15459.6 CCF32352.1 - 0.27 11.9 0.1 0.27 11.9 0.1 2.6 3 1 0 3 3 3 0 60S ribosome biogenesis protein Rrp14 G-patch_2 PF12656.7 CCF32352.1 - 1.6 8.8 8.1 0.39 10.8 3.7 2.3 2 0 0 2 2 2 0 G-patch domain Ank_2 PF12796.7 CCF32354.1 - 7.6e-21 74.5 0.6 5.4e-12 46.1 0.3 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CCF32354.1 - 1.7e-17 63.5 0.2 5e-08 33.3 0.0 2.6 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 CCF32354.1 - 2.3e-15 56.5 0.3 8.4e-08 32.3 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCF32354.1 - 5.8e-12 44.7 0.1 0.00033 20.9 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 CCF32354.1 - 1.4e-11 44.3 0.9 1e-05 25.7 0.1 2.8 3 0 0 3 3 3 2 Ankyrin repeat Phe_tRNA-synt_N PF02912.18 CCF32354.1 - 1.6e-05 24.7 0.0 0.00084 19.2 0.0 2.3 2 0 0 2 2 2 1 Aminoacyl tRNA synthetase class II, N-terminal domain TP6A_N PF04406.14 CCF32355.1 - 3.5e-20 71.8 0.1 5.9e-20 71.0 0.1 1.4 1 0 0 1 1 1 1 Type IIB DNA topoisomerase SQHop_cyclase_C PF13243.6 CCF32356.1 - 3.3e-47 161.2 1.0 3.5e-45 154.5 0.6 2.6 2 1 1 3 3 3 2 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 CCF32356.1 - 3.4e-37 128.1 5.6 3.6e-33 114.9 0.5 3.9 3 1 1 4 4 4 3 Squalene-hopene cyclase N-terminal domain Prenyltrans PF00432.21 CCF32356.1 - 1.2e-23 82.6 13.1 8e-10 38.3 0.3 5.2 5 0 0 5 5 5 3 Prenyltransferase and squalene oxidase repeat Pec_lyase PF09492.10 CCF32356.1 - 0.00053 19.4 0.5 0.18 11.1 0.0 3.3 4 0 0 4 4 4 2 Pectic acid lyase TED_complement PF07678.14 CCF32356.1 - 0.002 17.2 0.3 0.025 13.6 0.1 2.5 2 1 1 3 3 3 1 A-macroglobulin TED domain SGS PF05002.15 CCF32357.1 - 3.3e-21 75.2 1.3 3.3e-21 75.2 1.3 2.2 2 0 0 2 2 2 1 SGS domain CS PF04969.16 CCF32357.1 - 1.7e-07 32.1 0.0 4.1e-07 30.9 0.0 1.7 1 0 0 1 1 1 1 CS domain TPR_2 PF07719.17 CCF32357.1 - 0.00063 19.7 2.1 1.8 8.9 0.2 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat PRR18 PF15671.5 CCF32357.1 - 0.013 15.4 3.9 0.03 14.2 3.9 1.5 1 0 0 1 1 1 0 Proline-rich protein family 18 TPR_1 PF00515.28 CCF32357.1 - 0.23 11.3 2.6 1 9.3 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF2057 PF09829.9 CCF32357.1 - 1.5 8.9 8.5 0.57 10.3 3.0 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2057) PH_6 PF15406.6 CCF32358.1 - 3.4e-47 159.3 5.7 3.4e-47 159.3 5.7 2.5 3 0 0 3 3 3 1 Pleckstrin homology domain PH PF00169.29 CCF32358.1 - 2.6e-05 24.6 0.6 8.6e-05 23.0 0.0 2.2 2 1 0 2 2 2 1 PH domain IQ_SEC7_PH PF16453.5 CCF32358.1 - 0.053 13.5 0.0 0.09 12.8 0.0 1.4 1 0 0 1 1 1 0 PH domain GAGA_bind PF06217.12 CCF32358.1 - 1.4 9.1 13.2 0.024 14.9 6.1 1.6 2 0 0 2 2 2 0 GAGA binding protein-like family RPN6_N PF18055.1 CCF32360.1 - 5.2e-47 159.0 2.5 5.2e-47 159.0 2.5 2.5 3 0 0 3 3 3 1 26S proteasome regulatory subunit RPN6 N-terminal domain TPR_7 PF13176.6 CCF32360.1 - 3.5e-05 23.5 1.3 0.83 9.8 0.0 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_MalT PF17874.1 CCF32360.1 - 5.2e-05 22.8 1.4 5.2e-05 22.8 1.4 2.1 1 1 0 1 1 1 1 MalT-like TPR region TPR_12 PF13424.6 CCF32360.1 - 0.0009 19.5 13.6 0.013 15.8 1.2 4.4 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 CCF32360.1 - 0.0021 17.8 0.3 16 5.6 0.0 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat INT_SG_DDX_CT_C PF15300.6 CCF32360.1 - 0.014 15.2 0.0 0.043 13.6 0.0 1.8 2 0 0 2 2 2 0 INTS6/SAGE1/DDX26B/CT45 C-terminus TPR_4 PF07721.14 CCF32360.1 - 0.045 14.4 0.0 0.65 10.8 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat SesA PF17107.5 CCF32360.1 - 0.046 13.9 4.5 4.1 7.6 0.7 3.7 2 2 1 3 3 3 0 N-terminal domain on NACHT_NTPase and P-loop NTPases TPR_2 PF07719.17 CCF32360.1 - 0.051 13.7 4.4 18 5.8 0.0 4.6 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 CCF32360.1 - 0.12 13.2 7.9 12 7.1 0.0 4.7 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 CCF32360.1 - 0.27 11.5 7.4 18 5.9 0.1 5.0 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_11 PF13414.6 CCF32360.1 - 1.3 8.8 4.0 60 3.4 0.1 3.7 4 0 0 4 4 4 0 TPR repeat TPR_16 PF13432.6 CCF32360.1 - 6.4 7.5 8.9 3.5 8.3 0.5 3.5 3 1 0 3 3 3 0 Tetratricopeptide repeat WD40 PF00400.32 CCF32361.1 - 1.1e-29 102.1 13.5 4.1e-08 33.7 0.0 6.9 7 0 0 7 7 7 6 WD domain, G-beta repeat Sof1 PF04158.14 CCF32361.1 - 1.7e-29 101.9 12.9 3.4e-29 101.0 12.9 1.5 1 0 0 1 1 1 1 Sof1-like domain ANAPC4_WD40 PF12894.7 CCF32361.1 - 3e-10 40.2 0.0 0.00068 19.9 0.0 5.0 2 1 4 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 CCF32361.1 - 0.00045 20.2 0.0 8.3 6.5 0.0 4.5 2 2 3 5 5 5 2 Ciliary BBSome complex subunit 2, middle region Frtz PF11768.8 CCF32361.1 - 0.0041 15.5 0.0 0.15 10.3 0.0 2.5 2 0 0 2 2 2 1 WD repeat-containing and planar cell polarity effector protein Fritz Ge1_WD40 PF16529.5 CCF32361.1 - 0.043 12.8 0.1 7.5 5.4 0.0 3.1 2 2 2 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein adh_short PF00106.25 CCF32362.1 - 8e-39 133.1 0.2 1.2e-38 132.6 0.2 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF32362.1 - 8e-31 107.4 0.1 1.2e-30 106.8 0.1 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF32362.1 - 1.7e-10 41.1 3.6 1.5e-09 38.0 3.6 2.0 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF32362.1 - 0.011 15.2 0.2 0.023 14.2 0.1 1.5 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family GFA PF04828.14 CCF32363.1 - 5.7e-05 23.4 0.8 5.7e-05 23.4 0.8 1.6 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme Auto_anti-p27 PF06677.12 CCF32363.1 - 5.6 7.2 8.2 1.4 9.2 0.5 2.7 2 1 1 3 3 3 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) MFS_1 PF07690.16 CCF32364.1 - 2.1e-37 128.9 39.7 2.1e-37 128.9 39.7 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF32364.1 - 1.9e-13 50.1 9.4 1.9e-13 50.1 9.4 2.3 3 1 0 3 3 3 1 Sugar (and other) transporter MciZ PF13072.6 CCF32364.1 - 0.11 12.4 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 Mother cell inhibitor of FtsZ Pkinase PF00069.25 CCF32365.1 - 4.5e-48 163.9 0.0 6.3e-48 163.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF32365.1 - 1.3e-29 103.3 0.0 2e-29 102.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF32365.1 - 0.0035 16.7 0.1 0.007 15.7 0.1 1.5 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 CCF32365.1 - 0.0037 16.6 0.5 0.0037 16.6 0.5 2.0 2 1 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 CCF32365.1 - 0.019 14.6 0.0 0.037 13.6 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Pkinase_fungal PF17667.1 CCF32365.1 - 0.019 13.8 0.0 0.019 13.8 0.0 2.0 2 1 0 2 2 2 0 Fungal protein kinase Haspin_kinase PF12330.8 CCF32365.1 - 0.038 12.9 0.0 0.083 11.8 0.0 1.4 1 1 0 1 1 1 0 Haspin like kinase domain PIP49_C PF12260.8 CCF32365.1 - 0.091 12.4 0.1 0.14 11.8 0.1 1.2 1 0 0 1 1 1 0 Protein-kinase domain of FAM69 CDC45 PF02724.14 CCF32365.1 - 4.8 5.4 13.9 9 4.4 13.9 1.4 1 0 0 1 1 1 0 CDC45-like protein Glycogen_syn PF05693.13 CCF32366.1 - 0 1173.6 0.0 0 1173.3 0.0 1.0 1 0 0 1 1 1 1 Glycogen synthase Glyco_transf_4 PF13439.6 CCF32366.1 - 1.4e-05 25.1 0.3 3.1e-05 24.0 0.3 1.7 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_transf_5 PF08323.11 CCF32366.1 - 2.2e-05 24.3 0.1 4.4e-05 23.3 0.1 1.5 1 0 0 1 1 1 1 Starch synthase catalytic domain Glyco_trans_4_4 PF13579.6 CCF32366.1 - 0.00016 22.1 0.1 0.00038 20.9 0.1 1.6 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glycos_transf_1 PF00534.20 CCF32366.1 - 0.00019 21.0 0.0 0.031 13.8 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 CCF32366.1 - 0.00069 20.1 0.0 0.49 10.8 0.0 2.4 2 0 0 2 2 2 2 Glycosyl transferases group 1 F-box-like PF12937.7 CCF32367.1 - 6.7e-10 38.7 0.9 2.3e-09 37.0 0.9 2.0 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCF32367.1 - 0.0026 17.6 5.7 0.0057 16.5 1.6 3.1 3 1 0 3 3 3 1 F-box domain adh_short PF00106.25 CCF32369.1 - 1.2e-38 132.5 0.5 1.7e-38 132.0 0.1 1.4 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF32369.1 - 1.1e-26 93.9 0.1 1.3e-26 93.6 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.10 CCF32369.1 - 1.8e-05 24.3 0.0 3.8e-05 23.2 0.0 1.5 2 0 0 2 2 2 1 Fungal family of unknown function (DUF1776) ubiquitin PF00240.23 CCF32369.1 - 0.17 11.7 0.0 0.37 10.6 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin family AAA_16 PF13191.6 CCF32370.1 - 3.9e-06 27.4 0.4 1.7e-05 25.3 0.0 2.1 2 1 0 2 2 2 1 AAA ATPase domain NACHT PF05729.12 CCF32370.1 - 2.4e-05 24.3 0.0 8.7e-05 22.5 0.0 2.0 1 1 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 CCF32370.1 - 3e-05 24.3 0.0 9e-05 22.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain NB-ARC PF00931.22 CCF32370.1 - 0.00035 19.8 0.1 0.0042 16.3 0.0 2.3 2 1 0 2 2 2 1 NB-ARC domain NODP PF07684.12 CCF32370.1 - 0.047 13.8 0.0 0.15 12.3 0.0 1.9 1 0 0 1 1 1 0 NOTCH protein IstB_IS21 PF01695.17 CCF32370.1 - 0.066 12.9 0.0 0.17 11.6 0.0 1.7 1 0 0 1 1 1 0 IstB-like ATP binding protein PRK PF00485.18 CCF32370.1 - 0.12 12.1 0.0 6.8 6.4 0.0 2.3 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family Ank_2 PF12796.7 CCF32371.1 - 3e-26 91.8 6.3 1.1e-06 29.1 0.0 7.8 6 3 2 8 8 8 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CCF32371.1 - 4.9e-16 58.9 8.6 3.3e-06 27.5 0.0 8.9 9 1 2 11 11 11 4 Ankyrin repeats (many copies) Ank PF00023.30 CCF32371.1 - 2.6e-15 56.1 15.2 0.0027 18.1 0.0 9.5 9 1 1 10 10 10 5 Ankyrin repeat Ank_3 PF13606.6 CCF32371.1 - 1e-12 47.0 11.4 0.7 10.6 0.1 11.4 14 0 0 14 14 14 3 Ankyrin repeat Ank_5 PF13857.6 CCF32371.1 - 2.2e-08 34.2 1.3 0.079 13.3 0.0 6.9 6 1 1 7 7 7 2 Ankyrin repeats (many copies) Penicillinase_R PF03965.16 CCF32371.1 - 0.47 10.8 1.6 0.61 10.5 0.3 1.9 2 0 0 2 2 2 0 Penicillinase repressor ketoacyl-synt PF00109.26 CCF32372.1 - 2.8e-73 246.6 0.1 6.7e-73 245.4 0.1 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 CCF32372.1 - 7.1e-36 122.8 0.0 1.7e-35 121.6 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PS-DH PF14765.6 CCF32372.1 - 1.6e-21 76.8 0.0 6.7e-21 74.8 0.0 1.9 2 0 0 2 2 2 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 CCF32372.1 - 1.5e-20 73.9 0.0 6.9e-18 65.2 0.0 2.4 2 0 0 2 2 2 2 Acyl transferase domain SAT PF16073.5 CCF32372.1 - 1.6e-12 47.7 2.3 3.2e-08 33.6 0.3 2.7 2 0 0 2 2 2 2 Starter unit:ACP transacylase in aflatoxin biosynthesis KAsynt_C_assoc PF16197.5 CCF32372.1 - 7.1e-11 42.6 0.0 2.6e-10 40.8 0.0 2.0 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension PP-binding PF00550.25 CCF32372.1 - 3.3e-10 40.2 0.7 8.9e-10 38.8 0.7 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site Thiolase_N PF00108.23 CCF32372.1 - 2.4e-05 23.8 0.1 5.7e-05 22.6 0.1 1.6 1 0 0 1 1 1 1 Thiolase, N-terminal domain DUF4618 PF15397.6 CCF32372.1 - 0.062 12.7 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) NAD_binding_4 PF07993.12 CCF32373.1 - 1.4e-21 76.9 0.0 2.3e-21 76.2 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.21 CCF32373.1 - 2.1e-08 34.0 0.0 4.8e-08 32.8 0.0 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 CCF32373.1 - 1e-05 25.8 0.2 0.0001 22.6 0.2 2.5 1 1 0 1 1 1 1 Phosphopantetheine attachment site AMP-binding PF00501.28 CCF32373.1 - 0.0025 16.5 0.0 0.0043 15.7 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme Polysacc_synt_2 PF02719.15 CCF32373.1 - 0.035 13.3 0.0 0.77 8.8 0.0 2.3 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein RraA-like PF03737.15 CCF32375.1 - 8.3e-25 87.7 0.4 1.1e-24 87.4 0.4 1.1 1 0 0 1 1 1 1 Aldolase/RraA Glyco_hydro_2_N PF02837.18 CCF32377.1 - 3.3e-16 59.7 0.1 2.4e-15 56.9 0.1 2.5 2 1 0 2 2 2 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2_C PF02836.17 CCF32377.1 - 4.4e-11 42.4 0.1 3.4e-10 39.5 0.0 2.2 2 0 0 2 2 2 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2 PF00703.21 CCF32377.1 - 1.3e-08 35.5 0.1 2.9e-08 34.4 0.1 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 DUF4115 PF13464.6 CCF32377.1 - 0.59 10.4 2.5 0.44 10.8 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4115) SnoaL PF07366.12 CCF32378.1 - 6.3e-13 48.6 0.0 1.4e-12 47.5 0.0 1.6 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase SnoaL_2 PF12680.7 CCF32378.1 - 0.00095 19.8 0.3 0.0041 17.7 0.0 2.0 2 1 0 2 2 2 1 SnoaL-like domain GP3_package PF16677.5 CCF32380.1 - 0.1 12.7 0.0 0.18 11.9 0.0 1.3 1 0 0 1 1 1 0 DNA-packaging protein gp3 zf-CCCH PF00642.24 CCF32380.1 - 0.11 12.4 0.5 0.11 12.4 0.5 2.5 2 1 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) HA2 PF04408.23 CCF32381.1 - 1.8e-14 53.9 0.0 1.8e-14 53.9 0.0 2.9 3 0 0 3 3 2 1 Helicase associated domain (HA2) Helicase_C PF00271.31 CCF32381.1 - 1.7e-13 50.9 0.0 7.2e-13 48.9 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 CCF32381.1 - 5.2e-11 42.6 0.1 1.2e-10 41.4 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 CCF32381.1 - 5.8e-08 33.1 0.2 2.4e-07 31.1 0.2 2.0 1 0 0 1 1 1 1 AAA domain OB_NTP_bind PF07717.16 CCF32381.1 - 8.3e-08 32.5 0.0 1.8e-07 31.4 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold ABC_tran PF00005.27 CCF32381.1 - 0.0025 18.3 0.5 0.0097 16.4 0.0 2.2 2 0 0 2 2 2 1 ABC transporter AAA_29 PF13555.6 CCF32381.1 - 0.04 13.7 0.0 0.093 12.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain ATPase PF06745.13 CCF32381.1 - 0.085 12.2 0.1 0.21 10.9 0.0 1.7 2 0 0 2 2 2 0 KaiC RsgA_GTPase PF03193.16 CCF32381.1 - 0.13 12.1 0.0 0.61 10.0 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase Neuraminidase PF18413.1 CCF32381.1 - 0.17 11.5 2.1 0.23 11.1 0.2 2.2 2 0 0 2 2 2 0 Neuraminidase-like domain AAA_23 PF13476.6 CCF32381.1 - 0.73 10.3 0.0 0.73 10.3 0.0 3.0 4 0 0 4 4 3 0 AAA domain AAA_16 PF13191.6 CCF32381.1 - 1.3 9.4 4.2 0.77 10.1 0.1 2.7 2 0 0 2 2 2 0 AAA ATPase domain RRM_1 PF00076.22 CCF32382.1 - 4e-41 138.7 0.0 6.2e-13 48.4 0.0 4.5 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CCF32382.1 - 3e-30 103.9 0.0 3.7e-26 90.8 0.0 3.4 3 0 0 3 3 3 2 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 CCF32382.1 - 9.3e-09 35.2 0.0 0.00072 19.5 0.0 3.5 3 0 0 3 3 3 2 Nup53/35/40-type RNA recognition motif Nup35_RRM PF05172.13 CCF32382.1 - 3e-05 23.9 0.0 0.051 13.5 0.0 3.4 3 1 0 3 3 3 1 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.6 CCF32382.1 - 9.1e-05 22.1 0.0 0.0007 19.2 0.0 2.4 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) YqfD PF06898.11 CCF32382.1 - 3.4 6.4 5.7 0.33 9.7 0.9 1.7 2 0 0 2 2 2 0 Putative stage IV sporulation protein YqfD Neur_chan_memb PF02932.16 CCF32382.1 - 5 7.1 8.0 1.3 9.1 2.5 2.2 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Gly_transf_sug PF04488.15 CCF32384.1 - 9.7e-06 26.1 0.0 1.8e-05 25.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif AltA1 PF16541.5 CCF32385.1 - 4.8e-14 53.2 0.0 6.6e-14 52.7 0.0 1.1 1 0 0 1 1 1 1 Alternaria alternata allergen 1 PCI PF01399.27 CCF32386.1 - 2.5e-21 76.2 0.1 7.9e-21 74.5 0.1 1.9 1 0 0 1 1 1 1 PCI domain RPN5_C PF18098.1 CCF32386.1 - 2.1e-15 56.5 4.2 5.5e-15 55.2 4.2 1.8 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN5 C-terminal domain Synaptobrevin PF00957.21 CCF32386.1 - 0.21 11.4 1.5 8.8 6.2 0.5 2.8 2 0 0 2 2 2 0 Synaptobrevin FSH1 PF03959.13 CCF32387.1 - 2.8e-25 89.2 0.0 3.1e-25 89.1 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Hydrolase_4 PF12146.8 CCF32387.1 - 0.028 13.7 0.0 0.082 12.2 0.0 1.7 2 0 0 2 2 2 0 Serine aminopeptidase, S33 GRIP PF01465.20 CCF32388.1 - 2.3e-16 59.4 0.1 4.8e-16 58.4 0.1 1.6 1 0 0 1 1 1 1 GRIP domain CENP-F_leu_zip PF10473.9 CCF32388.1 - 2.7e-05 24.2 42.2 0.0079 16.2 19.4 3.3 1 1 2 3 3 3 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Filament PF00038.21 CCF32388.1 - 0.00012 21.8 35.7 0.0062 16.2 18.9 2.8 1 1 2 3 3 3 2 Intermediate filament protein Laminin_I PF06008.14 CCF32388.1 - 0.00047 19.9 25.5 0.00087 19.1 25.5 1.4 1 0 0 1 1 1 1 Laminin Domain I Baculo_PEP_C PF04513.12 CCF32388.1 - 0.00054 20.0 4.5 0.73 9.9 1.1 3.2 1 1 2 3 3 3 2 Baculovirus polyhedron envelope protein, PEP, C terminus TMPIT PF07851.13 CCF32388.1 - 0.0016 17.7 8.5 0.0016 17.7 8.5 2.2 1 1 0 2 2 2 1 TMPIT-like protein CCDC144C PF14915.6 CCF32388.1 - 0.0019 17.4 34.4 0.03 13.5 12.8 3.1 2 1 1 3 3 3 2 CCDC144C protein coiled-coil region GAS PF13851.6 CCF32388.1 - 0.0043 16.4 35.9 0.014 14.7 16.0 3.3 1 1 2 3 3 3 1 Growth-arrest specific micro-tubule binding MscS_porin PF12795.7 CCF32388.1 - 0.005 16.4 28.7 0.056 13.0 15.7 2.3 1 1 1 2 2 2 2 Mechanosensitive ion channel porin domain IFT57 PF10498.9 CCF32388.1 - 0.014 14.4 25.9 0.42 9.5 15.6 2.1 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 HOOK PF05622.12 CCF32388.1 - 0.014 13.5 35.1 0.021 13.0 22.7 2.3 1 1 1 2 2 2 0 HOOK protein DUF3584 PF12128.8 CCF32388.1 - 0.024 12.2 37.3 0.41 8.1 12.9 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) Rab5-bind PF09311.11 CCF32388.1 - 0.025 14.0 31.7 0.31 10.4 7.1 3.0 1 1 2 3 3 3 0 Rabaptin-like protein Spc7 PF08317.11 CCF32388.1 - 0.039 12.8 36.9 0.048 12.5 21.0 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein YnfE PF17452.2 CCF32388.1 - 0.039 14.2 2.0 0.039 14.2 2.0 2.1 1 1 1 2 2 1 0 Uncharacterized YnfE-like MAD PF05557.13 CCF32388.1 - 0.064 11.6 33.6 0.094 11.1 33.6 1.2 1 0 0 1 1 1 0 Mitotic checkpoint protein FH2 PF02181.23 CCF32388.1 - 0.084 12.0 22.6 0.079 12.1 11.7 2.7 1 1 1 2 2 2 0 Formin Homology 2 Domain NPV_P10 PF05531.12 CCF32388.1 - 0.087 13.3 7.6 0.5 10.9 0.4 3.7 1 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF948 PF06103.11 CCF32388.1 - 0.14 12.4 10.3 4.5 7.6 0.6 3.4 1 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF3080 PF11279.8 CCF32388.1 - 0.16 11.1 8.2 0.24 10.6 4.5 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3080) Fez1 PF06818.15 CCF32388.1 - 0.17 12.3 38.4 3.5 8.0 21.1 2.3 1 1 2 3 3 3 0 Fez1 DUF1664 PF07889.12 CCF32388.1 - 0.18 11.9 21.1 1.6 8.8 4.0 3.3 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Bacillus_HBL PF05791.11 CCF32388.1 - 0.18 11.6 5.8 2.2 8.1 0.7 3.1 1 1 2 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) DUF745 PF05335.13 CCF32388.1 - 0.27 10.9 22.9 0.05 13.3 11.4 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF745) AAA_13 PF13166.6 CCF32388.1 - 0.28 9.8 25.0 1.9 7.0 25.0 2.3 1 1 0 1 1 1 0 AAA domain Laminin_II PF06009.12 CCF32388.1 - 0.36 10.9 21.2 1.7 8.6 5.1 3.2 1 1 2 3 3 3 0 Laminin Domain II SH3BP5 PF05276.14 CCF32388.1 - 0.36 10.6 22.4 0.15 11.8 6.4 2.7 1 1 1 2 2 2 0 SH3 domain-binding protein 5 (SH3BP5) BLOC1_2 PF10046.9 CCF32388.1 - 0.48 10.8 19.4 1 9.7 3.2 3.9 1 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 APG17 PF04108.12 CCF32388.1 - 0.6 9.2 21.6 0.057 12.5 3.6 2.5 1 1 1 2 2 2 0 Autophagy protein Apg17 Fib_alpha PF08702.10 CCF32388.1 - 0.63 10.2 18.1 2.2 8.5 7.4 2.5 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family HMMR_N PF15905.5 CCF32388.1 - 0.67 9.4 37.4 1.7 8.0 27.4 2.1 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal Seryl_tRNA_N PF02403.22 CCF32388.1 - 0.67 10.2 35.4 0.32 11.2 14.2 3.3 1 1 2 3 3 3 0 Seryl-tRNA synthetase N-terminal domain TMF_DNA_bd PF12329.8 CCF32388.1 - 1 9.4 38.4 0.25 11.4 8.3 3.8 1 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding OmpH PF03938.14 CCF32388.1 - 1.1 9.5 34.6 0.22 11.8 11.1 3.2 1 1 1 2 2 1 0 Outer membrane protein (OmpH-like) YscO PF07321.12 CCF32388.1 - 1.2 9.1 45.0 0.32 10.9 11.3 3.3 1 1 1 3 3 3 0 Type III secretion protein YscO DUF3450 PF11932.8 CCF32388.1 - 1.3 8.3 31.3 3.7 6.8 3.0 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) HAP1_N PF04849.13 CCF32388.1 - 1.4 8.1 33.7 4.9 6.3 6.4 3.1 1 1 1 2 2 2 0 HAP1 N-terminal conserved region APG6_N PF17675.1 CCF32388.1 - 1.5 9.4 52.3 0.79 10.2 20.3 4.0 2 1 1 4 4 4 0 Apg6 coiled-coil region DUF2353 PF09789.9 CCF32388.1 - 1.6 8.0 39.5 1 8.6 26.3 2.2 1 1 1 2 2 2 0 Uncharacterized coiled-coil protein (DUF2353) Peptidase_S64 PF08192.11 CCF32388.1 - 1.7 7.0 7.0 2 6.8 7.0 1.2 1 0 0 1 1 1 0 Peptidase family S64 DUF724 PF05266.14 CCF32388.1 - 2.2 8.1 35.1 0.87 9.4 8.9 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF724) Phage_GPO PF05929.11 CCF32388.1 - 2.7 7.6 23.6 2.8 7.5 11.2 2.4 1 1 1 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase UPF0242 PF06785.11 CCF32388.1 - 2.9 7.9 40.2 0.73 9.9 15.1 2.4 2 1 1 3 3 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF4665 PF15679.5 CCF32388.1 - 3.2 8.4 13.6 11 6.7 3.1 3.4 1 1 1 3 3 3 0 Domain of unknown function (DUF4665) CREPT PF16566.5 CCF32388.1 - 3.6 7.7 27.3 6.9 6.8 4.8 2.9 2 1 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour TPR_MLP1_2 PF07926.12 CCF32388.1 - 3.7 7.6 44.3 48 4.0 23.1 3.6 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein CEP209_CC5 PF16574.5 CCF32388.1 - 4 7.6 35.9 2.5 8.3 26.6 2.4 1 1 1 2 2 2 0 Coiled-coil region of centrosome protein CE290 DHR10 PF18595.1 CCF32388.1 - 4.2 7.5 49.1 1.2 9.2 25.2 3.7 2 1 2 4 4 4 0 Designed helical repeat protein 10 domain Golgin_A5 PF09787.9 CCF32388.1 - 4.3 6.7 39.5 0.16 11.4 13.8 2.2 1 1 1 2 2 2 0 Golgin subfamily A member 5 Prefoldin_2 PF01920.20 CCF32388.1 - 4.6 7.2 33.5 5.1 7.1 2.1 4.9 2 1 2 4 4 4 0 Prefoldin subunit TraF_2 PF13729.6 CCF32388.1 - 6.1 6.1 5.4 4.4 6.6 0.2 2.4 2 1 1 3 3 3 0 F plasmid transfer operon, TraF, protein Wtap PF17098.5 CCF32388.1 - 6.5 6.7 32.0 0.13 12.1 2.4 3.7 2 1 1 3 3 3 0 WTAP/Mum2p family DivIC PF04977.15 CCF32388.1 - 7 6.5 30.8 0.54 10.1 7.2 4.2 1 1 2 4 4 4 0 Septum formation initiator Atg14 PF10186.9 CCF32388.1 - 7.9 5.5 35.6 2 7.5 7.0 2.9 1 1 1 2 2 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 HrpB7 PF09486.10 CCF32388.1 - 8 6.8 40.0 8.2 6.8 19.9 2.8 1 1 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) DUF641 PF04859.12 CCF32388.1 - 8.1 6.8 28.6 3.4 8.0 11.7 3.5 1 1 2 4 4 4 0 Plant protein of unknown function (DUF641) Lectin_N PF03954.14 CCF32388.1 - 8.3 6.2 15.2 6 6.6 2.8 3.2 1 1 2 3 3 3 0 Hepatic lectin, N-terminal domain Exonuc_VII_L PF02601.15 CCF32388.1 - 9.4 5.7 25.5 6.6e+02 -0.4 25.4 2.2 1 1 0 1 1 1 0 Exonuclease VII, large subunit adh_short PF00106.25 CCF32389.1 - 6.7e-41 139.9 3.0 1.1e-40 139.2 3.0 1.3 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF32389.1 - 2.5e-38 131.9 3.8 6.1e-38 130.7 3.8 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF32389.1 - 7.9e-08 32.4 2.6 8.8e-08 32.3 0.7 1.9 2 0 0 2 2 2 1 KR domain ADH_zinc_N PF00107.26 CCF32389.1 - 8.1e-06 25.9 0.1 1.9e-05 24.6 0.1 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase F420_oxidored PF03807.17 CCF32389.1 - 0.0049 17.4 0.3 0.012 16.2 0.3 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 CCF32389.1 - 0.022 14.8 0.2 0.045 13.8 0.0 1.6 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Epimerase PF01370.21 CCF32389.1 - 0.025 14.0 0.8 0.38 10.2 0.8 2.1 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 CCF32389.1 - 0.04 13.1 0.1 0.07 12.3 0.1 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein AdoHcyase_NAD PF00670.21 CCF32389.1 - 0.094 12.8 1.4 0.18 11.8 1.4 1.6 1 1 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain NAD_binding_7 PF13241.6 CCF32389.1 - 0.13 12.7 0.5 0.33 11.4 0.3 1.8 2 1 0 2 2 2 0 Putative NAD(P)-binding 3HCDH_N PF02737.18 CCF32389.1 - 0.27 11.1 3.1 4 7.3 0.6 2.8 2 1 1 3 3 3 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Dynamin_N PF00350.23 CCF32390.1 - 3.3e-24 85.8 0.0 6.4e-24 84.9 0.0 1.5 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 CCF32390.1 - 1e-15 57.7 0.0 6.4e-10 38.7 0.0 2.3 2 0 0 2 2 2 2 Dynamin central region MMR_HSR1 PF01926.23 CCF32390.1 - 4e-05 23.6 0.0 0.00017 21.7 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_29 PF13555.6 CCF32390.1 - 0.014 15.1 0.1 0.044 13.5 0.0 1.8 2 0 0 2 2 2 0 P-loop containing region of AAA domain GED PF02212.18 CCF32390.1 - 0.015 15.4 1.2 0.031 14.4 0.3 2.0 3 0 0 3 3 3 0 Dynamin GTPase effector domain AAA_21 PF13304.6 CCF32390.1 - 0.021 14.7 0.0 0.035 13.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system Med21 PF11221.8 CCF32390.1 - 0.032 14.5 0.1 0.073 13.3 0.1 1.6 1 0 0 1 1 1 0 Subunit 21 of Mediator complex AAA_16 PF13191.6 CCF32390.1 - 0.062 13.7 0.1 0.25 11.7 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain AAA_15 PF13175.6 CCF32390.1 - 0.11 12.2 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA_23 PF13476.6 CCF32390.1 - 0.14 12.6 0.0 5.2 7.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain Peptidase_S10 PF00450.22 CCF32391.1 - 2.9e-07 30.3 0.0 3.4e-07 30.0 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase DUF676 PF05057.14 CCF32392.1 - 4.3e-51 173.5 0.0 6.4e-51 172.9 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Palm_thioest PF02089.15 CCF32392.1 - 2.6e-05 24.2 0.0 4e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Abhydrolase_6 PF12697.7 CCF32392.1 - 0.00019 22.1 0.3 0.0017 19.0 0.0 2.1 1 1 1 2 2 2 1 Alpha/beta hydrolase family PGAP1 PF07819.13 CCF32392.1 - 0.00043 20.1 0.0 0.003 17.3 0.0 2.2 1 1 0 1 1 1 1 PGAP1-like protein DUF1449 PF07290.11 CCF32392.1 - 0.058 13.0 0.0 0.1 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1449) Lipase_2 PF01674.18 CCF32392.1 - 0.12 11.8 0.0 0.22 11.0 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 2) Lipase_3 PF01764.25 CCF32392.1 - 0.16 11.8 0.0 0.3 11.0 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) SPX PF03105.19 CCF32393.1 - 1.2 8.9 8.9 2.1 8.1 8.9 1.3 1 0 0 1 1 1 0 SPX domain RsfS PF02410.15 CCF32394.1 - 2.7e-13 50.2 0.0 1e-12 48.3 0.0 2.0 2 0 0 2 2 2 1 Ribosomal silencing factor during starvation RNA_pol PF00940.19 CCF32395.1 - 1.8e-186 620.0 0.0 4.5e-186 618.7 0.0 1.6 1 1 0 1 1 1 1 DNA-dependent RNA polymerase RPOL_N PF14700.6 CCF32395.1 - 4.2e-103 345.3 1.2 6.7e-103 344.6 1.2 1.3 1 0 0 1 1 1 1 DNA-directed RNA polymerase N-terminal Drc1-Sld2 PF11719.8 CCF32395.1 - 0.00068 19.3 0.0 0.0016 18.0 0.0 1.6 1 0 0 1 1 1 1 DNA replication and checkpoint protein DHHA2 PF02833.14 CCF32396.1 - 7.4e-26 91.1 0.0 8.1e-26 90.9 0.0 1.0 1 0 0 1 1 1 1 DHHA2 domain Seipin PF06775.14 CCF32398.1 - 7.6e-36 124.1 0.0 1e-35 123.7 0.0 1.2 1 0 0 1 1 1 1 Putative adipose-regulatory protein (Seipin) FCH PF00611.23 CCF32399.1 - 3.3e-15 56.1 0.0 8e-15 54.9 0.0 1.7 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain Not1 PF04054.15 CCF32400.1 - 1.6e-124 415.6 0.1 4.4e-124 414.1 0.0 1.8 2 0 0 2 2 2 1 CCR4-Not complex component, Not1 CNOT1_CAF1_bind PF16415.5 CCF32400.1 - 1.6e-92 309.0 1.8 3.4e-92 307.9 1.8 1.6 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 CAF1-binding domain DUF3819 PF12842.7 CCF32400.1 - 2.2e-49 167.2 1.7 2.2e-49 167.2 1.7 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF3819) CNOT1_TTP_bind PF16417.5 CCF32400.1 - 4.1e-42 143.5 0.0 1.3e-41 141.9 0.0 1.8 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 TTP binding domain CNOT1_HEAT PF16418.5 CCF32400.1 - 6.9e-39 133.3 3.6 3.1e-38 131.2 0.6 2.7 2 0 0 2 2 2 1 CCR4-NOT transcription complex subunit 1 HEAT repeat FKBP_C PF00254.28 CCF32401.1 - 2.9e-32 110.9 0.0 4.3e-32 110.3 0.0 1.3 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Pkinase PF00069.25 CCF32402.1 - 1.8e-27 96.4 0.0 5.6e-27 94.8 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF32402.1 - 1.6e-05 24.4 0.0 0.003 16.9 0.0 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase CI-B14_5a PF07347.12 CCF32406.1 - 0.068 13.1 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a) AhpC-TSA PF00578.21 CCF32407.1 - 2e-24 85.9 0.0 3.2e-24 85.2 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 CCF32407.1 - 3.8e-14 52.6 0.1 5.7e-14 52.0 0.1 1.4 1 0 0 1 1 1 1 Redoxin AhpC-TSA_2 PF13911.6 CCF32407.1 - 0.00047 20.2 0.0 0.0028 17.8 0.0 2.0 1 1 1 2 2 2 1 AhpC/TSA antioxidant enzyme AbfS_sensor PF18225.1 CCF32407.1 - 0.064 13.2 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Sensor histidine kinase (AbfS) sensor domain Mito_carr PF00153.27 CCF32408.1 - 2.8e-64 213.1 3.5 5.9e-22 77.4 0.0 3.3 2 1 1 3 3 3 3 Mitochondrial carrier protein DUF1180 PF06679.12 CCF32410.1 - 0.036 14.5 0.4 0.046 14.2 0.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Tyrosinase PF00264.20 CCF32411.1 - 2.3e-48 165.4 0.0 2.9e-48 165.1 0.0 1.1 1 0 0 1 1 1 1 Common central domain of tyrosinase VacA2 PF03077.14 CCF32412.1 - 0.13 12.1 0.1 0.24 11.3 0.1 1.4 1 0 0 1 1 1 0 Putative vacuolating cytotoxin PMI_typeI PF01238.21 CCF32413.1 - 3.8e-22 79.0 0.0 4.3e-22 78.8 0.0 1.0 1 0 0 1 1 1 1 Phosphomannose isomerase type I Cupin_2 PF07883.11 CCF32413.1 - 1.8e-07 30.7 0.1 0.0015 18.2 0.1 2.3 2 0 0 2 2 2 2 Cupin domain AraC_binding PF02311.19 CCF32413.1 - 6.6e-05 22.8 0.0 0.0051 16.7 0.0 2.2 2 0 0 2 2 2 2 AraC-like ligand binding domain Cupin_3 PF05899.12 CCF32413.1 - 0.00011 21.8 0.1 0.012 15.2 0.1 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF861) Cupin_4 PF08007.12 CCF32413.1 - 0.087 12.3 0.0 0.098 12.1 0.0 1.1 1 0 0 1 1 1 0 Cupin superfamily protein Ank_2 PF12796.7 CCF32414.1 - 2e-18 66.7 1.2 3.7e-05 24.2 0.0 5.1 5 1 0 5 5 5 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CCF32414.1 - 5.2e-16 57.1 7.7 0.0024 18.2 0.0 8.3 9 0 0 9 9 9 5 Ankyrin repeat Ank_4 PF13637.6 CCF32414.1 - 7.9e-16 58.2 1.1 3e-06 27.7 0.0 6.3 6 0 0 6 6 6 3 Ankyrin repeats (many copies) Ank PF00023.30 CCF32414.1 - 1.6e-13 50.4 8.7 0.0012 19.2 0.0 6.3 6 0 0 6 6 6 3 Ankyrin repeat Ank_5 PF13857.6 CCF32414.1 - 2e-09 37.5 7.0 0.00018 21.8 0.0 5.5 5 0 0 5 5 5 2 Ankyrin repeats (many copies) GLTP PF08718.11 CCF32415.1 - 2e-48 164.5 0.0 2.8e-48 164.0 0.0 1.2 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) MatE PF01554.18 CCF32417.1 - 4.5e-36 123.9 23.7 3.2e-23 82.2 6.5 2.8 2 1 0 2 2 2 2 MatE Polysacc_synt_C PF14667.6 CCF32417.1 - 1.5e-06 28.3 2.6 1.5e-06 28.3 2.6 4.1 3 1 1 4 4 4 1 Polysaccharide biosynthesis C-terminal domain Bestrophin PF01062.21 CCF32417.1 - 0.035 13.5 0.6 0.087 12.2 0.6 1.7 1 0 0 1 1 1 0 Bestrophin, RFP-TM, chloride channel HTH_Bact PF18768.1 CCF32417.1 - 0.13 11.8 0.1 0.41 10.3 0.1 1.8 1 0 0 1 1 1 0 Helix-turn-helix bacterial domain Sod_Cu PF00080.20 CCF32418.1 - 5.6e-09 36.3 0.0 8.3e-09 35.8 0.0 1.2 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) Sdh_cyt PF01127.22 CCF32420.1 - 4.6e-06 26.7 0.1 5.8e-06 26.3 0.1 1.2 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit PLU-1 PF08429.11 CCF32421.1 - 2.2e-110 369.0 17.4 2.6e-107 358.9 15.6 2.2 2 0 0 2 2 2 2 PLU-1-like protein JmjC PF02373.22 CCF32421.1 - 5.4e-43 146.0 0.2 1.2e-42 144.9 0.2 1.7 1 0 0 1 1 1 1 JmjC domain, hydroxylase ARID PF01388.21 CCF32421.1 - 2.1e-21 76.4 0.0 6e-21 74.9 0.0 1.9 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain JmjN PF02375.17 CCF32421.1 - 6.3e-16 58.0 2.3 1.4e-15 56.9 2.3 1.7 1 0 0 1 1 1 1 jmjN domain PHD PF00628.29 CCF32421.1 - 2.6e-15 56.0 43.0 9.5e-09 35.0 11.2 4.5 4 0 0 4 4 4 2 PHD-finger zf-C5HC2 PF02928.16 CCF32421.1 - 6.3e-13 48.9 2.5 6.3e-13 48.9 2.5 2.2 2 0 0 2 2 2 1 C5HC2 zinc finger zf-HC5HC2H PF13771.6 CCF32421.1 - 0.0048 17.1 17.5 0.029 14.6 1.5 3.4 3 0 0 3 3 3 2 PHD-like zinc-binding domain zf-PHD-like PF15446.6 CCF32421.1 - 0.017 14.7 11.9 0.058 13.0 3.9 2.7 2 0 0 2 2 2 0 PHD/FYVE-zinc-finger like domain zf-HC5HC2H_2 PF13832.6 CCF32421.1 - 0.12 12.5 16.8 0.2 11.9 1.7 3.2 3 0 0 3 3 3 0 PHD-zinc-finger like domain C1_1 PF00130.22 CCF32421.1 - 0.46 10.4 20.8 0.54 10.2 4.4 3.4 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) RIBIOP_C PF04950.12 CCF32423.1 - 4.1e-94 315.3 0.2 4.1e-94 315.3 0.2 2.0 2 0 0 2 2 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 CCF32423.1 - 2.3e-27 94.9 0.0 9.6e-27 92.9 0.0 2.2 1 0 0 1 1 1 1 AARP2CN (NUC121) domain AAA_22 PF13401.6 CCF32423.1 - 1.9e-05 24.9 0.1 6e-05 23.3 0.0 1.9 2 0 0 2 2 1 1 AAA domain AAA_16 PF13191.6 CCF32423.1 - 0.00011 22.7 0.0 0.00043 20.7 0.0 2.0 1 0 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 CCF32423.1 - 0.00024 21.3 2.4 0.0016 18.6 0.0 2.8 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 CCF32423.1 - 0.00045 20.2 0.0 0.0011 18.9 0.0 1.7 1 1 0 1 1 1 1 NACHT domain AAA PF00004.29 CCF32423.1 - 0.00048 20.6 0.0 0.0015 19.0 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) GTP_EFTU PF00009.27 CCF32423.1 - 0.0007 19.2 0.0 0.16 11.5 0.0 2.6 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain ABC_tran PF00005.27 CCF32423.1 - 0.0009 19.8 2.1 0.0037 17.8 0.0 3.0 3 0 0 3 3 3 1 ABC transporter MMR_HSR1 PF01926.23 CCF32423.1 - 0.0013 18.8 0.0 0.0044 17.1 0.0 2.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CCF32423.1 - 0.0026 17.7 0.0 0.17 11.7 0.0 3.0 3 0 0 3 3 2 1 RsgA GTPase AAA_19 PF13245.6 CCF32423.1 - 0.0042 17.4 0.1 0.016 15.6 0.0 2.0 2 0 0 2 2 1 1 AAA domain RNA_helicase PF00910.22 CCF32423.1 - 0.0063 16.9 0.0 0.017 15.5 0.0 1.8 1 0 0 1 1 1 1 RNA helicase PduV-EutP PF10662.9 CCF32423.1 - 0.0065 16.2 0.0 0.026 14.3 0.0 1.9 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation AAA_30 PF13604.6 CCF32423.1 - 0.012 15.3 1.2 0.034 13.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 CCF32423.1 - 0.013 14.6 0.0 0.035 13.3 0.0 1.6 2 0 0 2 2 2 0 NB-ARC domain AAA_14 PF13173.6 CCF32423.1 - 0.016 15.2 0.0 0.059 13.4 0.0 2.0 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 CCF32423.1 - 0.016 14.8 0.1 0.035 13.7 0.1 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Ploopntkinase3 PF18751.1 CCF32423.1 - 0.035 14.0 0.0 0.077 12.9 0.0 1.5 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 AAA_18 PF13238.6 CCF32423.1 - 0.036 14.6 7.8 0.042 14.4 0.0 3.8 4 0 0 4 4 3 0 AAA domain Roc PF08477.13 CCF32423.1 - 0.042 14.1 0.0 0.15 12.3 0.0 2.0 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase MobB PF03205.14 CCF32423.1 - 0.043 13.7 1.4 0.46 10.4 0.1 2.9 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B NTPase_1 PF03266.15 CCF32423.1 - 0.044 13.7 0.1 0.093 12.6 0.1 1.5 1 0 0 1 1 1 0 NTPase AAA_5 PF07728.14 CCF32423.1 - 0.06 13.3 1.1 0.21 11.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 CCF32423.1 - 0.087 12.4 0.0 0.22 11.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 CCF32423.1 - 0.13 11.7 0.0 0.26 10.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region WD40 PF00400.32 CCF32424.1 - 7.6e-11 42.4 2.5 0.0014 19.4 0.0 4.4 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF32424.1 - 0.00039 20.6 0.1 1 9.7 0.0 3.9 4 0 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CCF32424.1 - 0.0018 17.3 3.1 2.1 7.2 0.0 3.5 4 0 0 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein GMC_oxred_C PF05199.13 CCF32427.1 - 4.8e-17 62.8 0.0 5.3e-17 62.7 0.0 1.0 1 0 0 1 1 1 1 GMC oxidoreductase Epimerase PF01370.21 CCF32428.1 - 1.7e-15 57.1 0.0 3.7e-15 56.0 0.0 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 CCF32428.1 - 3.3e-10 39.6 0.1 2.2e-08 33.6 0.1 2.3 1 1 0 1 1 1 1 Male sterility protein 3Beta_HSD PF01073.19 CCF32428.1 - 4.3e-09 35.8 0.0 7.6e-09 35.0 0.0 1.3 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 CCF32428.1 - 2.1e-06 27.4 0.1 4.6e-06 26.3 0.0 1.5 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 CCF32428.1 - 0.00055 19.9 0.0 0.0009 19.2 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 CCF32428.1 - 0.0014 18.3 0.0 0.0078 15.8 0.0 2.0 2 0 0 2 2 2 1 NmrA-like family KR PF08659.10 CCF32428.1 - 0.0059 16.5 0.0 0.018 14.9 0.0 1.8 1 1 0 1 1 1 1 KR domain adh_short PF00106.25 CCF32428.1 - 0.016 14.7 0.0 1.1 8.6 0.0 2.9 2 1 0 2 2 2 0 short chain dehydrogenase RmlD_sub_bind PF04321.17 CCF32428.1 - 0.088 11.9 0.0 0.2 10.7 0.0 1.6 1 1 0 1 1 1 0 RmlD substrate binding domain MFS_1 PF07690.16 CCF32429.1 - 1.1e-28 100.3 24.3 1.1e-28 100.2 23.1 1.5 1 1 1 2 2 2 1 Major Facilitator Superfamily DUF4381 PF14316.6 CCF32429.1 - 0.0044 17.3 0.1 0.03 14.6 0.0 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4381) UNC-93 PF05978.16 CCF32429.1 - 2.6 7.7 13.3 0.79 9.4 3.9 3.1 2 1 1 3 3 3 0 Ion channel regulatory protein UNC-93 Aldedh PF00171.22 CCF32430.1 - 4.7e-127 424.3 0.0 5.5e-127 424.1 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 CCF32430.1 - 3.1e-05 23.5 0.0 4.9e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1487) Mito_carr PF00153.27 CCF32431.1 - 1.4e-30 105.1 0.4 1.1e-15 57.3 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Sugar_tr PF00083.24 CCF32432.1 - 8.7e-107 357.8 14.7 1e-106 357.5 14.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF32432.1 - 5.2e-29 101.3 45.6 5.8e-27 94.5 20.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 CCF32432.1 - 4.4e-09 35.4 18.3 5.8e-06 25.1 4.3 2.9 3 0 0 3 3 3 2 MFS/sugar transport protein MFS_1_like PF12832.7 CCF32432.1 - 0.0021 17.0 9.1 0.0045 15.9 0.2 2.5 2 1 0 2 2 2 2 MFS_1 like family DUF2530 PF10745.9 CCF32432.1 - 4.4 7.6 7.4 2 8.7 0.2 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2530) Septin PF00735.18 CCF32433.1 - 1.6e-90 303.2 0.2 1.8e-90 303.0 0.2 1.0 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 CCF32433.1 - 7.5e-08 32.5 0.0 1.3e-07 31.7 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 CCF32433.1 - 1.8e-06 27.4 0.0 3e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 AIG1 family RsgA_GTPase PF03193.16 CCF32433.1 - 3.3e-06 27.1 0.2 0.00011 22.1 0.1 2.2 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 CCF32433.1 - 7.1e-06 25.7 0.7 0.001 18.6 0.0 2.3 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 CCF32433.1 - 0.00056 20.0 0.2 1 9.4 0.1 2.5 1 1 1 2 2 2 2 Dynamin family NB-ARC PF00931.22 CCF32433.1 - 0.002 17.3 0.1 0.0035 16.6 0.1 1.3 1 0 0 1 1 1 1 NB-ARC domain AAA_7 PF12775.7 CCF32433.1 - 0.0026 17.3 0.1 0.018 14.5 0.0 2.1 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_22 PF13401.6 CCF32433.1 - 0.0036 17.6 0.0 0.0066 16.7 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CCF32433.1 - 0.0042 17.5 0.0 0.011 16.2 0.0 1.6 2 0 0 2 2 2 1 AAA ATPase domain ABC_tran PF00005.27 CCF32433.1 - 0.0062 17.0 0.2 0.0099 16.4 0.2 1.6 1 1 0 1 1 1 1 ABC transporter Gtr1_RagA PF04670.12 CCF32433.1 - 0.0082 15.5 0.1 0.17 11.2 0.0 2.2 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region Roc PF08477.13 CCF32433.1 - 0.018 15.2 0.0 0.036 14.3 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Microtub_bd PF16796.5 CCF32433.1 - 0.036 14.0 0.1 0.25 11.3 0.0 2.1 2 0 0 2 2 2 0 Microtubule binding G-alpha PF00503.20 CCF32433.1 - 0.039 13.1 0.6 0.28 10.3 0.1 2.0 1 1 1 2 2 2 0 G-protein alpha subunit FtsK_SpoIIIE PF01580.18 CCF32433.1 - 0.053 12.9 0.0 0.1 12.0 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family Ras PF00071.22 CCF32433.1 - 0.058 13.0 0.0 0.2 11.2 0.0 1.9 2 1 0 2 2 2 0 Ras family T2SSE PF00437.20 CCF32433.1 - 0.11 11.6 0.0 0.19 10.7 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_29 PF13555.6 CCF32433.1 - 0.14 11.9 0.0 0.28 11.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Ribosomal_L32p PF01783.23 CCF32434.1 - 1.2e-13 51.1 7.6 1.7e-13 50.6 7.6 1.2 1 0 0 1 1 1 1 Ribosomal L32p protein family zf-ribbon_3 PF13248.6 CCF32434.1 - 0.021 14.3 6.8 0.034 13.6 6.8 1.3 1 0 0 1 1 1 0 zinc-ribbon domain DUF3654 PF12376.8 CCF32434.1 - 0.12 12.6 0.4 0.15 12.2 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3654) zf-ACC PF17848.1 CCF32434.1 - 6.2 7.0 9.0 4.6e+02 1.0 9.0 2.4 1 1 0 1 1 1 0 Acetyl-coA carboxylase zinc finger domain WD40 PF00400.32 CCF32435.1 - 5.1e-21 74.6 10.7 2.2e-08 34.6 0.3 6.3 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF32435.1 - 1.8e-14 53.8 2.1 0.00034 20.9 0.5 4.4 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 CCF32435.1 - 0.0006 19.2 0.0 0.0064 15.9 0.0 2.4 2 1 0 2 2 2 1 WD40-like domain Nbas_N PF15492.6 CCF32435.1 - 0.0052 16.2 0.1 0.75 9.1 0.0 3.0 2 1 1 3 3 3 1 Neuroblastoma-amplified sequence, N terminal eIF2A PF08662.11 CCF32435.1 - 0.0056 16.6 0.4 0.029 14.2 0.0 2.3 2 2 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A Lactonase PF10282.9 CCF32435.1 - 0.0068 15.7 0.0 0.082 12.1 0.0 2.3 1 1 1 2 2 2 1 Lactonase, 7-bladed beta-propeller Ge1_WD40 PF16529.5 CCF32435.1 - 0.018 14.0 0.2 2.9 6.7 0.0 3.2 2 2 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 CCF32435.1 - 0.062 11.9 0.2 0.11 11.1 0.1 1.5 2 0 0 2 2 2 0 Nucleoporin Nup120/160 Coatomer_WDAD PF04053.14 CCF32435.1 - 0.16 10.9 0.0 0.17 10.9 0.0 1.2 1 0 0 1 1 1 0 Coatomer WD associated region FG-GAP_2 PF14312.6 CCF32435.1 - 0.53 10.6 3.0 3 8.2 0.9 2.9 2 1 0 2 2 2 0 FG-GAP repeat DNA_pol_delta_4 PF04081.13 CCF32436.1 - 1.7e-43 148.1 1.1 2.3e-43 147.7 1.1 1.2 1 0 0 1 1 1 1 DNA polymerase delta, subunit 4 Q_salvage PF10343.9 CCF32437.1 - 3.2e-128 427.2 0.0 3.8e-128 426.9 0.0 1.1 1 0 0 1 1 1 1 Potential Queuosine, Q, salvage protein family DUF1563 PF07599.11 CCF32437.1 - 0.04 14.0 0.1 0.077 13.1 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1563) ThiF PF00899.21 CCF32438.1 - 1.2e-73 247.5 0.0 1.9e-73 246.8 0.0 1.2 1 0 0 1 1 1 1 ThiF family UAE_UbL PF14732.6 CCF32438.1 - 4e-25 88.2 0.8 5.6e-24 84.6 0.2 2.4 2 0 0 2 2 2 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain UBA_e1_thiolCys PF10585.9 CCF32438.1 - 2.4e-06 27.7 7.8 3.1e-06 27.3 0.7 2.9 2 1 1 3 3 3 1 Ubiquitin-activating enzyme active site NAD_binding_7 PF13241.6 CCF32438.1 - 0.00086 19.7 0.1 0.0026 18.2 0.1 1.8 1 0 0 1 1 1 1 Putative NAD(P)-binding Pex14_N PF04695.13 CCF32438.1 - 0.0059 17.3 13.0 0.016 15.9 13.0 1.6 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region DASH_Dam1 PF08653.10 CCF32438.1 - 0.022 14.6 0.6 0.25 11.2 0.3 2.4 2 0 0 2 2 2 0 DASH complex subunit Dam1 Shikimate_DH PF01488.20 CCF32438.1 - 0.078 13.0 0.1 0.18 11.9 0.1 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase adh_short_C2 PF13561.6 CCF32439.1 - 1.8e-42 145.5 2.0 9.6e-28 97.3 0.0 3.0 2 1 1 3 3 3 3 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF32439.1 - 5.7e-39 133.6 3.0 2.1e-18 66.5 0.0 3.0 2 1 1 3 3 3 3 short chain dehydrogenase KR PF08659.10 CCF32439.1 - 6.4e-07 29.5 0.2 2e-06 27.8 0.0 1.8 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 CCF32439.1 - 0.015 14.8 0.5 0.16 11.4 0.5 2.3 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family 3HCDH_N PF02737.18 CCF32439.1 - 0.062 13.2 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF1194 PF06707.11 CCF32439.1 - 0.12 11.5 0.0 0.18 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1194) ApbA PF02558.16 CCF32439.1 - 0.15 11.7 0.2 0.35 10.5 0.2 1.8 1 1 0 1 1 1 0 Ketopantoate reductase PanE/ApbA PAP2 PF01569.21 CCF32440.1 - 1.7e-19 69.9 0.4 6.9e-19 68.0 0.4 2.0 1 0 0 1 1 1 1 PAP2 superfamily PAP2_3 PF14378.6 CCF32440.1 - 0.0011 18.7 1.9 0.0011 18.7 1.9 2.6 4 0 0 4 4 4 1 PAP2 superfamily Peptidase_U4 PF03419.13 CCF32440.1 - 0.062 12.6 0.1 0.062 12.6 0.1 1.8 2 0 0 2 2 2 0 Sporulation factor SpoIIGA zf-C3HC4_3 PF13920.6 CCF32441.1 - 4.1e-05 23.3 11.1 4.1e-05 23.3 11.1 2.5 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CCF32441.1 - 0.00011 22.1 9.7 0.00011 22.1 9.7 2.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.6 CCF32441.1 - 0.0004 20.7 10.0 0.0004 20.7 10.0 2.4 2 0 0 2 2 2 1 Ring finger domain Prok-RING_4 PF14447.6 CCF32441.1 - 0.009 15.9 9.3 0.009 15.9 9.3 2.1 2 1 1 3 3 3 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 CCF32441.1 - 0.29 11.2 6.6 0.77 9.8 6.6 1.7 1 0 0 1 1 1 0 RING-type zinc-finger Cys_rich_KTR PF14205.6 CCF32441.1 - 1.3 8.9 0.0 1.3 8.9 0.0 2.6 3 0 0 3 3 3 0 Cysteine-rich KTR DnaJ PF00226.31 CCF32442.1 - 0.018 15.2 0.3 1.1 9.5 0.0 2.5 2 0 0 2 2 2 0 DnaJ domain Herpes_IE68 PF02479.16 CCF32442.1 - 0.044 13.4 0.0 0.15 11.6 0.0 1.8 2 0 0 2 2 2 0 Herpesvirus immediate early protein zf-B_box PF00643.24 CCF32442.1 - 1.1 9.4 6.7 3.4 7.9 6.7 1.8 1 0 0 1 1 1 0 B-box zinc finger Fungal_trans PF04082.18 CCF32443.1 - 6.6e-13 48.3 0.8 1.4e-12 47.2 0.8 1.7 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF32443.1 - 6.7e-10 38.9 8.3 1.3e-09 38.0 8.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sugarporin_N PF11471.8 CCF32443.1 - 0.62 10.1 3.1 1.5 8.9 3.1 1.6 1 0 0 1 1 1 0 Maltoporin periplasmic N-terminal extension BTB PF00651.31 CCF32444.1 - 1.2e-07 31.9 0.0 2.4e-07 31.0 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain VLPT PF07122.11 CCF32444.1 - 0.048 13.4 0.0 0.1 12.4 0.0 1.5 1 0 0 1 1 1 0 Variable length PCR target protein (VLPT) Glyco_transf_90 PF05686.12 CCF32447.1 - 2.9e-11 42.9 2.6 3e-10 39.6 2.2 2.5 2 1 0 2 2 2 1 Glycosyl transferase family 90 Pkinase PF00069.25 CCF32448.1 - 3.6e-55 187.2 0.3 2.7e-35 122.0 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCF32448.1 - 2e-37 128.9 0.0 1.6e-36 125.9 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF32448.1 - 0.00011 21.6 0.0 0.00026 20.4 0.0 1.6 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 CCF32448.1 - 0.041 13.8 0.0 0.17 11.8 0.0 1.9 2 0 0 2 2 2 0 Phosphotransferase enzyme family DUF3896 PF13035.6 CCF32448.1 - 0.052 13.7 1.5 0.14 12.4 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3896) Pkinase_fungal PF17667.1 CCF32448.1 - 0.077 11.8 0.0 0.15 10.8 0.0 1.5 2 0 0 2 2 2 0 Fungal protein kinase BTB PF00651.31 CCF32449.1 - 2e-22 79.5 0.3 9.5e-13 48.4 0.4 2.8 3 0 0 3 3 3 2 BTB/POZ domain Ank_2 PF12796.7 CCF32449.1 - 3.4e-08 34.0 0.0 7.4e-08 32.9 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CCF32449.1 - 4.3e-08 33.5 0.1 1.2e-07 32.2 0.1 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 CCF32449.1 - 3.2e-06 27.3 0.0 8.4e-06 26.0 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 CCF32449.1 - 3.5e-05 24.0 0.3 0.01 16.2 0.1 2.7 2 0 0 2 2 2 1 Ankyrin repeat Ank_3 PF13606.6 CCF32449.1 - 4.7e-05 23.5 0.2 0.51 11.1 0.1 2.9 2 0 0 2 2 2 2 Ankyrin repeat SAICAR_synt PF01259.18 CCF32450.1 - 4.1e-102 341.1 0.0 4.9e-102 340.9 0.0 1.1 1 0 0 1 1 1 1 SAICAR synthetase Asp PF00026.23 CCF32451.1 - 2e-60 204.8 1.9 2.7e-60 204.4 1.9 1.2 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCF32451.1 - 5.6e-11 43.0 2.0 1.7e-09 38.2 2.0 2.3 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal AIM24 PF01987.17 CCF32451.1 - 0.00039 20.3 0.3 0.0025 17.6 0.3 2.2 1 1 0 1 1 1 1 Mitochondrial biogenesis AIM24 Transket_pyr PF02779.24 CCF32454.1 - 3.9e-58 196.0 0.0 6.3e-58 195.4 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.20 CCF32454.1 - 1.3e-53 181.9 0.0 1.9e-53 181.3 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component OxoGdeHyase_C PF16870.5 CCF32454.1 - 6.6e-52 175.2 0.0 1.1e-51 174.5 0.0 1.4 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal 2-oxogl_dehyd_N PF16078.5 CCF32454.1 - 2.6e-19 68.5 1.2 2.6e-19 68.5 1.2 1.8 2 0 0 2 2 2 1 2-oxoglutarate dehydrogenase N-terminus 2-oxoacid_dh PF00198.23 CCF32455.1 - 2.9e-76 256.0 0.1 4.4e-76 255.4 0.1 1.3 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 CCF32455.1 - 6e-18 64.4 4.7 1e-17 63.7 4.7 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 CCF32455.1 - 5.4e-06 26.1 0.7 0.00014 21.7 0.0 2.5 1 1 1 2 2 2 1 Biotin-lipoyl like HlyD_3 PF13437.6 CCF32455.1 - 0.00074 20.2 1.2 0.26 12.0 0.1 2.6 1 1 1 2 2 2 2 HlyD family secretion protein GCV_H PF01597.19 CCF32455.1 - 0.0037 17.2 3.0 0.011 15.6 2.6 2.0 1 1 1 2 2 2 1 Glycine cleavage H-protein RnfC_N PF13375.6 CCF32455.1 - 0.0038 17.2 1.6 1.3 9.0 0.3 2.6 1 1 1 2 2 2 2 RnfC Barrel sandwich hybrid domain HlyD_D23 PF16576.5 CCF32455.1 - 0.0049 16.1 1.0 0.047 12.9 0.1 2.3 1 1 1 2 2 2 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion DUF2118 PF09891.9 CCF32455.1 - 0.021 14.8 0.9 0.14 12.1 0.2 2.1 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2118) Beta_helix PF13229.6 CCF32456.1 - 1e-13 51.4 11.2 1.7e-11 44.2 3.8 2.3 1 1 1 2 2 2 2 Right handed beta helix region Chondroitinas_B PF14592.6 CCF32456.1 - 6.3e-08 31.9 0.1 1.1e-06 27.8 0.0 2.5 3 0 0 3 3 3 1 Chondroitinase B NosD PF05048.13 CCF32456.1 - 0.00061 19.1 13.3 0.0025 17.1 13.3 2.2 1 1 0 1 1 1 1 Periplasmic copper-binding protein (NosD) DUF1565 PF07602.11 CCF32456.1 - 0.014 14.7 2.1 0.098 12.0 0.1 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1565) SGL PF08450.12 CCF32457.1 - 1.7e-25 90.0 1.2 3.4e-25 89.1 1.3 1.5 1 1 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Str_synth PF03088.16 CCF32457.1 - 5.4e-06 26.5 0.0 2e-05 24.6 0.0 1.9 1 1 0 1 1 1 1 Strictosidine synthase Arylesterase PF01731.20 CCF32457.1 - 0.0017 18.5 0.2 0.017 15.3 0.1 2.5 2 1 1 3 3 3 1 Arylesterase GspH PF12019.8 CCF32457.1 - 0.0034 17.8 2.4 0.44 11.0 0.1 3.0 2 1 1 3 3 3 2 Type II transport protein GspH NHL PF01436.21 CCF32457.1 - 0.052 13.6 3.1 3.6 7.8 0.0 3.4 3 0 0 3 3 3 0 NHL repeat PD40 PF07676.12 CCF32457.1 - 0.45 10.5 2.3 0.71 9.9 0.1 2.4 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat Rad51 PF08423.11 CCF32458.1 - 0.00015 21.1 0.0 0.036 13.3 0.0 2.3 2 0 0 2 2 2 2 Rad51 ATPase PF06745.13 CCF32458.1 - 0.00049 19.5 0.1 0.0011 18.4 0.0 1.6 2 0 0 2 2 2 1 KaiC AAA_24 PF13479.6 CCF32458.1 - 0.0032 17.2 0.0 0.0059 16.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain DnaB_C PF03796.15 CCF32458.1 - 0.0064 15.8 0.0 0.32 10.3 0.0 2.2 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain AAA_25 PF13481.6 CCF32458.1 - 0.011 15.3 0.4 4.8 6.7 0.0 2.9 2 1 0 2 2 2 0 AAA domain RecA PF00154.21 CCF32458.1 - 0.11 11.9 0.0 0.69 9.3 0.0 2.0 2 0 0 2 2 2 0 recA bacterial DNA recombination protein Cwf_Cwc_15 PF04889.12 CCF32458.1 - 0.31 10.8 3.2 0.49 10.1 3.2 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein UNC-93 PF05978.16 CCF32464.1 - 1.1e-09 38.2 6.9 1.1e-09 38.2 6.9 2.8 3 1 1 4 4 4 1 Ion channel regulatory protein UNC-93 MFS_1 PF07690.16 CCF32464.1 - 1.2e-06 27.7 43.7 1.2e-06 27.7 43.7 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily EXS PF03124.14 CCF32464.1 - 0.0037 16.6 2.1 0.0037 16.6 2.1 2.0 2 0 0 2 2 2 1 EXS family Pex14_N PF04695.13 CCF32465.1 - 1.1e-29 104.1 12.0 1.1e-29 104.1 12.0 4.0 2 2 0 2 2 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Golgin_A5 PF09787.9 CCF32465.1 - 0.0031 17.0 9.9 0.0051 16.3 9.9 1.3 1 0 0 1 1 1 1 Golgin subfamily A member 5 zf-C4H2 PF10146.9 CCF32465.1 - 0.004 17.5 4.9 0.004 17.5 4.9 2.0 2 0 0 2 2 2 1 Zinc finger-containing protein ERM PF00769.19 CCF32465.1 - 0.0079 16.0 7.8 0.013 15.3 7.8 1.3 1 0 0 1 1 1 1 Ezrin/radixin/moesin family HLH PF00010.26 CCF32465.1 - 0.035 14.1 0.1 12 6.0 0.1 2.8 2 1 0 2 2 2 0 Helix-loop-helix DNA-binding domain DUF1043 PF06295.12 CCF32465.1 - 0.041 13.9 5.3 0.061 13.3 4.2 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1043) Baculo_PEP_C PF04513.12 CCF32465.1 - 0.044 13.8 8.1 1.1 9.4 2.6 2.2 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF16 PF01519.16 CCF32465.1 - 0.059 13.9 7.0 0.28 11.7 2.5 2.3 2 0 0 2 2 2 0 Protein of unknown function DUF16 DUF188 PF02639.14 CCF32465.1 - 0.066 12.9 0.4 1.6 8.4 0.0 2.4 2 0 0 2 2 2 0 Uncharacterized BCR, YaiI/YqxD family COG1671 Prominin PF05478.11 CCF32465.1 - 0.074 11.0 2.9 0.1 10.5 2.9 1.1 1 0 0 1 1 1 0 Prominin SKA2 PF16740.5 CCF32465.1 - 0.14 11.9 8.0 2.3 8.0 1.7 2.5 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 2 DUF572 PF04502.13 CCF32465.1 - 0.2 11.2 9.0 0.27 10.8 9.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) APG17 PF04108.12 CCF32465.1 - 0.3 10.1 8.7 0.55 9.3 8.7 1.4 1 1 0 1 1 1 0 Autophagy protein Apg17 UPF0242 PF06785.11 CCF32465.1 - 0.38 10.8 6.7 0.57 10.3 6.7 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Plasmid_RAQPRD PF09686.10 CCF32465.1 - 0.42 10.9 3.9 0.86 9.9 1.3 2.4 1 1 1 2 2 2 0 Plasmid protein of unknown function (Plasmid_RAQPRD) Spc7 PF08317.11 CCF32465.1 - 1.1 8.1 10.3 1.9 7.3 10.3 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Nup88 PF10168.9 CCF32465.1 - 2.4 5.9 8.4 3.5 5.3 8.4 1.1 1 0 0 1 1 1 0 Nuclear pore component Csm1_N PF18504.1 CCF32465.1 - 5.4 7.4 9.1 2.1 8.7 4.5 2.5 1 1 2 3 3 3 0 Csm1 N-terminal domain TMPIT PF07851.13 CCF32465.1 - 6 6.0 6.4 10 5.3 6.4 1.4 1 0 0 1 1 1 0 TMPIT-like protein DUF4404 PF14357.6 CCF32465.1 - 7.1 7.3 8.2 10 6.8 6.5 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4404) Abhydrolase_3 PF07859.13 CCF32466.1 - 2.9e-46 158.0 0.0 6.8e-46 156.8 0.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 CCF32466.1 - 6.2e-05 22.0 0.1 0.00026 20.0 0.1 1.9 1 1 0 1 1 1 1 Steryl acetyl hydrolase FAD_binding_4 PF01565.23 CCF32467.1 - 1.8e-15 56.9 0.0 3.1e-15 56.1 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain ARPC4 PF05856.12 CCF32468.1 - 1.3e-78 262.4 2.9 1.4e-78 262.2 2.9 1.0 1 0 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) UCH PF00443.29 CCF32469.1 - 1.2e-48 165.9 0.0 1.6e-48 165.4 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 CCF32469.1 - 2.4e-12 46.4 0.2 5.9e-11 42.0 0.1 2.4 2 0 0 2 2 2 1 Ubiquitin family UCH_1 PF13423.6 CCF32469.1 - 1e-11 45.0 6.1 3.1e-10 40.1 6.1 2.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Ubiquitin_2 PF14560.6 CCF32469.1 - 0.025 15.0 0.1 0.3 11.5 0.0 2.4 2 0 0 2 2 2 0 Ubiquitin-like domain EPO_TPO PF00758.18 CCF32469.1 - 0.026 14.6 0.1 2.9 7.9 0.0 2.3 2 0 0 2 2 2 0 Erythropoietin/thrombopoietin TBK1_ULD PF18396.1 CCF32469.1 - 0.14 12.1 0.0 0.3 11.1 0.0 1.5 1 0 0 1 1 1 0 TANK binding kinase 1 ubiquitin-like domain His_Phos_1 PF00300.22 CCF32471.1 - 1.4e-36 126.0 2.0 1.2e-18 67.5 0.5 2.4 2 1 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) Methyltransf_23 PF13489.6 CCF32472.1 - 0.00026 20.8 0.0 0.00035 20.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF32472.1 - 0.0022 18.7 0.0 0.0038 18.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF32472.1 - 0.0037 17.9 0.0 0.0064 17.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCF32472.1 - 0.091 12.1 0.0 0.14 11.4 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family SelP_N PF04592.14 CCF32472.1 - 0.66 9.3 7.1 0.87 8.9 7.1 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Thiolase_N PF00108.23 CCF32473.1 - 1.8e-66 224.2 0.4 2.3e-66 223.8 0.4 1.1 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 CCF32473.1 - 3.8e-40 136.3 0.2 8.8e-40 135.2 0.2 1.6 1 0 0 1 1 1 1 Thiolase, C-terminal domain Glyco_hydro_cc PF11790.8 CCF32474.1 - 3.5e-69 233.0 0.5 4.1e-69 232.8 0.5 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core Fip1 PF05182.13 CCF32474.1 - 0.029 13.9 0.3 0.073 12.6 0.3 1.7 1 0 0 1 1 1 0 Fip1 motif Carb_anhydrase PF00194.21 CCF32475.1 - 2.7e-21 76.3 0.2 4.6e-21 75.5 0.2 1.3 1 1 0 1 1 1 1 Eukaryotic-type carbonic anhydrase ShlB PF03865.13 CCF32475.1 - 0.097 12.1 0.1 2.3 7.6 0.1 2.1 2 0 0 2 2 2 0 Haemolysin secretion/activation protein ShlB/FhaC/HecB G-alpha PF00503.20 CCF32478.1 - 5.7e-111 371.1 0.2 6.6e-111 370.9 0.2 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 CCF32478.1 - 1.3e-13 50.7 0.5 3.1e-08 33.2 0.1 2.5 2 1 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 CCF32478.1 - 0.00024 20.5 0.6 0.024 14.0 0.0 2.3 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 CCF32478.1 - 0.026 14.7 0.2 5.6 7.2 0.0 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_25 PF13481.6 CCF32478.1 - 0.047 13.3 0.0 0.078 12.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 CCF32478.1 - 0.14 11.9 0.0 0.27 11.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.18 CCF32478.1 - 0.15 11.4 0.0 0.25 10.7 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family CN_hydrolase PF00795.22 CCF32479.1 - 2.7e-55 187.5 0.0 3.1e-55 187.3 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Pectate_lyase_3 PF12708.7 CCF32480.1 - 1e-17 64.7 0.1 1e-16 61.4 0.1 2.0 1 1 0 1 1 1 1 Pectate lyase superfamily protein TPR_12 PF13424.6 CCF32482.1 - 2.6e-12 46.9 18.3 0.021 15.1 0.9 8.5 8 0 0 8 8 8 3 Tetratricopeptide repeat AAA_22 PF13401.6 CCF32482.1 - 1.4e-06 28.6 0.0 1.3e-05 25.5 0.0 2.8 2 0 0 2 2 1 1 AAA domain NACHT PF05729.12 CCF32482.1 - 5.5e-06 26.4 0.0 2.3e-05 24.4 0.0 2.1 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 CCF32482.1 - 3.9e-05 24.1 0.0 0.00016 22.1 0.0 2.1 1 0 0 1 1 1 1 AAA ATPase domain ATPase_2 PF01637.18 CCF32482.1 - 7.6e-05 22.7 0.0 0.00055 19.9 0.0 2.4 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea TPR_1 PF00515.28 CCF32482.1 - 0.00059 19.5 2.5 26 4.9 0.0 5.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 CCF32482.1 - 0.0033 17.5 8.5 24 5.4 0.5 5.8 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.6 CCF32482.1 - 0.0094 15.9 15.7 2.6 8.3 0.2 7.2 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_19 PF14559.6 CCF32482.1 - 0.015 15.8 1.9 6.4 7.4 0.0 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.17 CCF32482.1 - 3.5 8.0 14.3 11 6.4 0.3 6.0 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_6 PF13174.6 CCF32482.1 - 4.7 8.1 11.9 9.1 7.2 0.2 4.9 4 1 1 5 5 4 0 Tetratricopeptide repeat Methyltransf_33 PF10017.9 CCF32483.1 - 4.2e-80 269.2 0.0 4.7e-80 269.0 0.0 1.0 1 0 0 1 1 1 1 Histidine-specific methyltransferase, SAM-dependent Fungal_trans_2 PF11951.8 CCF32484.1 - 8.1e-27 94.0 1.7 6.4e-26 91.1 1.7 1.9 1 1 0 1 1 1 1 Fungal specific transcription factor domain TFIIB PF00382.19 CCF32484.1 - 0.023 14.8 0.0 0.055 13.5 0.0 1.6 1 0 0 1 1 1 0 Transcription factor TFIIB repeat ELFV_dehydrog PF00208.21 CCF32485.1 - 1.6e-65 221.2 0.0 2.6e-65 220.6 0.0 1.3 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Bac_GDH PF05088.12 CCF32485.1 - 1.4e-17 62.7 0.1 6.1e-13 47.3 0.0 2.5 2 1 1 3 3 3 2 Bacterial NAD-glutamate dehydrogenase ELFV_dehydrog_N PF02812.18 CCF32485.1 - 0.0071 16.2 0.0 0.04 13.8 0.0 2.1 2 0 0 2 2 2 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain zf-HIT PF04438.16 CCF32487.1 - 2.6e-09 36.8 9.2 3.9e-09 36.2 9.2 1.3 1 0 0 1 1 1 1 HIT zinc finger Cwf_Cwc_15 PF04889.12 CCF32487.1 - 0.24 11.1 21.2 0.025 14.3 6.4 2.6 3 0 0 3 3 3 0 Cwf15/Cwc15 cell cycle control protein zf-MYND PF01753.18 CCF32487.1 - 0.26 11.4 7.9 0.59 10.3 7.9 1.6 1 0 0 1 1 1 0 MYND finger Ribosomal_L37ae PF01780.19 CCF32487.1 - 2 8.5 5.8 0.61 10.2 0.1 2.5 2 0 0 2 2 2 0 Ribosomal L37ae protein family DENN PF02141.21 CCF32488.1 - 6e-40 137.2 0.1 1e-39 136.4 0.1 1.4 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.18 CCF32488.1 - 4.8e-07 30.4 0.2 2.8e-06 28.0 0.0 2.4 2 0 0 2 2 2 1 uDENN domain Elongin_A PF06881.11 CCF32488.1 - 0.0052 17.3 6.7 0.025 15.1 6.7 2.1 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A IFT57 PF10498.9 CCF32488.1 - 0.0058 15.6 6.2 0.0058 15.6 6.2 2.2 1 1 1 2 2 2 1 Intra-flagellar transport protein 57 DUF5345 PF17280.2 CCF32488.1 - 0.24 11.4 0.8 0.82 9.7 0.8 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5345) TMF_TATA_bd PF12325.8 CCF32488.1 - 5 7.4 17.0 4.7 7.5 4.1 2.7 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding zf-H2C2_2 PF13465.6 CCF32489.1 - 1.7e-06 28.2 7.3 1.9e-05 24.9 1.1 2.7 2 0 0 2 2 2 2 Zinc-finger double domain Fungal_trans PF04082.18 CCF32489.1 - 8.7e-06 24.9 5.5 6.8e-05 22.0 5.5 2.0 1 1 0 1 1 1 1 Fungal specific transcription factor domain zf-Di19 PF05605.12 CCF32489.1 - 0.00076 19.7 4.4 0.0016 18.7 4.4 1.5 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 CCF32489.1 - 0.0013 19.4 15.1 0.064 14.1 5.8 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CCF32489.1 - 0.17 12.2 3.1 8.9 6.7 0.8 2.7 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 CCF32489.1 - 0.34 11.5 14.6 0.38 11.3 7.3 2.8 2 0 0 2 2 2 0 Zinc finger, C2H2 type Nucleoporin_N PF08801.11 CCF32492.1 - 4.2e-97 325.7 0.0 6e-97 325.1 0.0 1.2 1 0 0 1 1 1 1 Nup133 N terminal like Nucleoporin_C PF03177.14 CCF32492.1 - 3.6e-52 177.9 2.3 6e-51 173.9 0.2 2.0 1 1 0 2 2 2 2 Non-repetitive/WGA-negative nucleoporin C-terminal Phasin_2 PF09361.10 CCF32492.1 - 0.0012 19.1 0.3 0.0057 16.9 0.3 2.3 1 0 0 1 1 1 1 Phasin protein YihI PF04220.12 CCF32492.1 - 0.07 12.8 0.7 0.14 11.9 0.7 1.4 1 0 0 1 1 1 0 Der GTPase activator (YihI) adh_short PF00106.25 CCF32493.1 - 1.6e-40 138.7 0.0 2.2e-40 138.2 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF32493.1 - 6.7e-26 91.3 0.0 1e-25 90.7 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF32493.1 - 7.6e-07 29.2 0.1 3.1e-06 27.2 0.1 1.9 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 CCF32493.1 - 0.0048 16.1 0.0 0.0064 15.7 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 CCF32493.1 - 0.064 13.1 0.0 0.094 12.6 0.0 1.3 1 0 0 1 1 1 0 NAD(P)H-binding DUF3638 PF12340.8 CCF32493.1 - 0.11 11.9 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3638) Erg28 PF03694.13 CCF32494.1 - 2.7e-44 150.1 0.3 3.2e-44 149.8 0.3 1.1 1 0 0 1 1 1 1 Erg28 like protein GalP_UDP_tr_C PF02744.17 CCF32495.1 - 2.7e-57 193.1 0.1 3.1e-57 192.9 0.1 1.0 1 0 0 1 1 1 1 Galactose-1-phosphate uridyl transferase, C-terminal domain HIT PF01230.23 CCF32495.1 - 2.1e-06 28.4 0.2 3.1e-06 27.8 0.2 1.3 1 1 0 1 1 1 1 HIT domain DcpS_C PF11969.8 CCF32495.1 - 0.022 15.2 0.3 0.044 14.3 0.3 1.5 1 1 0 1 1 1 0 Scavenger mRNA decapping enzyme C-term binding HTH_ParB PF17762.1 CCF32495.1 - 0.11 12.3 0.1 0.21 11.5 0.1 1.4 1 0 0 1 1 1 0 HTH domain found in ParB protein Sugar_tr PF00083.24 CCF32497.1 - 2.4e-110 369.5 22.1 2.9e-110 369.2 22.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF32497.1 - 1e-20 74.0 28.2 4.8e-15 55.3 2.7 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily SIX1_SD PF16878.5 CCF32497.1 - 0.065 13.7 0.0 0.12 12.9 0.0 1.4 1 0 0 1 1 1 0 Transcriptional regulator, SIX1, N-terminal SD domain Fungal_trans PF04082.18 CCF32498.1 - 3.6e-11 42.6 2.5 1.4e-10 40.7 1.4 2.6 2 1 0 2 2 2 1 Fungal specific transcription factor domain FAD_binding_3 PF01494.19 CCF32499.1 - 6.5e-78 262.4 0.0 8.2e-78 262.1 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 CCF32499.1 - 7.2e-06 26.1 0.0 2.4e-05 24.4 0.0 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CCF32499.1 - 8.3e-06 25.6 0.1 6.6e-05 22.6 0.0 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 CCF32499.1 - 0.00017 21.1 0.0 0.0028 17.0 0.0 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCF32499.1 - 0.00047 19.5 0.0 0.0031 16.8 0.0 2.2 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CCF32499.1 - 0.0077 15.4 0.0 0.013 14.6 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 CCF32499.1 - 0.01 16.4 0.0 0.2 12.2 0.0 2.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CCF32499.1 - 0.012 14.4 0.0 0.018 13.8 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein Thi4 PF01946.17 CCF32499.1 - 0.017 14.4 0.0 0.03 13.6 0.0 1.3 1 0 0 1 1 1 0 Thi4 family Lycopene_cycl PF05834.12 CCF32499.1 - 0.03 13.4 0.5 1.2 8.1 0.0 2.2 2 0 0 2 2 2 0 Lycopene cyclase protein Trp_halogenase PF04820.14 CCF32499.1 - 0.052 12.4 0.0 0.13 11.1 0.0 1.6 2 0 0 2 2 2 0 Tryptophan halogenase Pyr_redox_3 PF13738.6 CCF32499.1 - 0.07 12.4 0.0 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Amidohydro_1 PF01979.20 CCF32500.1 - 6.7e-40 137.5 0.1 8.4e-40 137.1 0.1 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 CCF32500.1 - 2.2e-11 43.9 2.7 4.9e-09 36.2 0.1 2.2 2 0 0 2 2 2 2 Amidohydrolase family ASL_C2 PF14698.6 CCF32500.1 - 0.17 12.7 0.0 0.6 10.9 0.0 2.0 1 0 0 1 1 1 0 Argininosuccinate lyase C-terminal Pterin_4a PF01329.19 CCF32501.1 - 1.1e-24 86.3 0.1 1.6e-24 85.9 0.1 1.2 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase FA_hydroxylase PF04116.13 CCF32502.1 - 1.4e-25 90.2 15.7 1.4e-25 90.2 15.7 2.1 2 1 1 3 3 3 1 Fatty acid hydroxylase superfamily AAA PF00004.29 CCF32503.1 - 2.5e-45 154.2 0.6 7.7e-45 152.6 0.0 2.1 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 CCF32503.1 - 1.2e-10 41.2 0.1 7.6e-10 38.6 0.0 2.3 2 0 0 2 2 2 1 Proteasomal ATPase OB C-terminal domain AAA_5 PF07728.14 CCF32503.1 - 2.3e-08 34.1 0.8 6.6e-08 32.6 0.1 2.2 2 2 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 CCF32503.1 - 5.2e-08 33.2 0.0 1.1e-07 32.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 CCF32503.1 - 2.8e-07 31.1 0.6 3.7e-05 24.2 0.0 2.8 2 1 1 3 3 3 1 AAA ATPase domain DUF815 PF05673.13 CCF32503.1 - 3.2e-06 26.5 0.0 6.9e-06 25.4 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_22 PF13401.6 CCF32503.1 - 3.4e-05 24.2 0.9 0.0088 16.3 0.1 2.7 1 1 1 2 2 2 1 AAA domain RuvB_N PF05496.12 CCF32503.1 - 0.00024 20.9 0.0 0.00073 19.3 0.0 1.8 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_lid_3 PF17862.1 CCF32503.1 - 0.00038 20.2 0.0 0.00086 19.1 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_18 PF13238.6 CCF32503.1 - 0.00047 20.7 0.0 0.0013 19.3 0.0 1.7 2 0 0 2 2 1 1 AAA domain AAA_28 PF13521.6 CCF32503.1 - 0.00068 19.9 0.0 0.0014 18.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 CCF32503.1 - 0.00087 18.9 0.1 0.0032 17.0 0.1 1.8 1 1 0 1 1 1 1 P-loop containing dynein motor region TIP49 PF06068.13 CCF32503.1 - 0.0011 18.3 0.0 0.002 17.4 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain TsaE PF02367.17 CCF32503.1 - 0.0014 18.7 0.0 0.019 15.0 0.0 2.2 1 1 1 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 CCF32503.1 - 0.002 18.2 0.1 0.0078 16.3 0.0 1.9 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 CCF32503.1 - 0.0021 18.4 0.0 0.0046 17.3 0.0 1.6 1 0 0 1 1 1 1 RNA helicase NTPase_1 PF03266.15 CCF32503.1 - 0.0032 17.4 0.0 0.015 15.2 0.0 2.0 2 0 0 2 2 2 1 NTPase NACHT PF05729.12 CCF32503.1 - 0.0042 17.0 0.6 0.11 12.3 0.0 3.0 3 1 0 4 4 4 1 NACHT domain AAA_30 PF13604.6 CCF32503.1 - 0.0054 16.5 1.1 0.013 15.2 0.1 2.2 2 1 0 2 2 2 1 AAA domain AAA_3 PF07726.11 CCF32503.1 - 0.0056 16.5 0.0 0.018 14.9 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 CCF32503.1 - 0.0071 15.7 0.2 0.016 14.6 0.1 1.7 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 CCF32503.1 - 0.0083 16.3 0.0 0.019 15.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 CCF32503.1 - 0.0095 15.7 0.1 0.03 14.0 0.0 1.9 2 0 0 2 2 2 1 IstB-like ATP binding protein TniB PF05621.11 CCF32503.1 - 0.013 14.9 0.0 0.5 9.7 0.0 2.3 2 0 0 2 2 2 0 Bacterial TniB protein Viral_Hsp90 PF03225.14 CCF32503.1 - 0.019 13.5 0.0 0.029 12.9 0.0 1.2 1 0 0 1 1 1 0 Viral heat shock protein Hsp90 homologue AAA_24 PF13479.6 CCF32503.1 - 0.022 14.5 0.2 0.055 13.2 0.2 1.8 1 1 0 1 1 1 0 AAA domain AFG1_ATPase PF03969.16 CCF32503.1 - 0.037 12.9 0.0 0.13 11.1 0.0 1.8 2 0 0 2 2 2 0 AFG1-like ATPase AAA_11 PF13086.6 CCF32503.1 - 0.037 13.8 0.1 0.14 12.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain Bac_DnaA PF00308.18 CCF32503.1 - 0.04 13.8 0.0 0.077 12.8 0.0 1.5 1 0 0 1 1 1 0 Bacterial dnaA protein ATPase_2 PF01637.18 CCF32503.1 - 0.042 13.8 1.0 0.34 10.8 0.0 2.6 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea ATPase PF06745.13 CCF32503.1 - 0.042 13.2 1.3 0.56 9.5 0.0 2.5 3 0 0 3 3 3 0 KaiC Sigma54_activat PF00158.26 CCF32503.1 - 0.068 12.9 0.2 1.3 8.7 0.0 2.5 2 1 0 2 2 2 0 Sigma-54 interaction domain AAA_25 PF13481.6 CCF32503.1 - 0.071 12.7 1.2 0.19 11.2 0.3 2.1 2 1 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 CCF32503.1 - 0.088 12.1 0.1 0.22 10.8 0.0 1.7 2 0 0 2 2 1 0 Zeta toxin AAA_19 PF13245.6 CCF32503.1 - 0.13 12.6 0.1 0.37 11.1 0.1 1.7 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 CCF32503.1 - 0.14 11.7 0.0 0.34 10.5 0.0 1.6 1 1 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_29 PF13555.6 CCF32503.1 - 0.16 11.7 0.0 0.33 10.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain SPACA9 PF15120.6 CCF32503.1 - 0.19 11.5 1.3 15 5.4 0.0 2.2 2 0 0 2 2 2 0 Sperm acrosome-associated protein 9 Parvo_NS1 PF01057.17 CCF32503.1 - 0.2 10.7 0.0 0.37 9.8 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Mis14 PF08641.12 CCF32505.1 - 6.9e-28 97.6 0.5 1e-27 97.0 0.5 1.3 1 0 0 1 1 1 1 Kinetochore protein Mis14 like CRAL_TRIO PF00650.20 CCF32506.1 - 8.9e-36 123.0 0.0 1.4e-35 122.4 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 CCF32506.1 - 7.7e-08 32.4 0.8 2e-07 31.1 0.0 2.1 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 CCF32506.1 - 0.011 15.9 0.0 0.022 14.9 0.0 1.4 1 0 0 1 1 1 0 Divergent CRAL/TRIO domain DUF1769 PF08588.10 CCF32506.1 - 0.1 12.8 0.0 0.23 11.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1769) Prefoldin PF02996.17 CCF32507.1 - 5.5e-35 119.9 0.0 8.4e-35 119.3 0.0 1.3 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin_2 PF01920.20 CCF32507.1 - 0.00037 20.4 5.4 0.0021 18.0 0.0 2.8 3 1 0 3 3 3 1 Prefoldin subunit FlaC_arch PF05377.11 CCF32507.1 - 0.0036 17.7 1.0 0.14 12.6 0.1 2.6 2 1 0 2 2 2 1 Flagella accessory protein C (FlaC) Filament PF00038.21 CCF32507.1 - 0.011 15.3 1.4 0.75 9.3 0.1 2.1 2 0 0 2 2 2 0 Intermediate filament protein End3 PF12761.7 CCF32507.1 - 0.031 14.4 0.8 0.13 12.4 0.4 2.1 1 1 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 DUF4795 PF16043.5 CCF32507.1 - 0.053 13.1 3.8 1.5 8.4 0.2 2.1 1 1 0 2 2 2 0 Domain of unknown function (DUF4795) PIP49_N PF14875.6 CCF32507.1 - 0.16 11.8 0.1 0.27 11.1 0.1 1.3 1 0 0 1 1 1 0 N-term cysteine-rich ER, FAM69 Lebercilin PF15619.6 CCF32507.1 - 0.17 11.6 3.7 0.46 10.1 1.0 2.0 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DUF4201 PF13870.6 CCF32507.1 - 0.19 11.5 2.8 0.63 9.8 0.1 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4201) Mito_carr PF00153.27 CCF32508.1 - 1.6e-57 191.4 2.8 3.3e-20 71.8 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein RINT1_TIP1 PF04437.13 CCF32509.1 - 1.5e-181 604.6 0.0 3e-181 603.7 0.0 1.5 2 0 0 2 2 2 1 RINT-1 / TIP-1 family DHR10 PF18595.1 CCF32509.1 - 0.026 14.6 2.6 0.099 12.7 2.6 2.0 1 0 0 1 1 1 0 Designed helical repeat protein 10 domain CRISPR_Cse2 PF09485.10 CCF32509.1 - 0.053 14.1 2.7 0.28 11.7 2.7 2.3 1 0 0 1 1 1 0 CRISPR-associated protein Cse2 (CRISPR_cse2) Com_YlbF PF06133.11 CCF32509.1 - 0.11 13.1 3.3 0.35 11.5 3.1 1.9 1 1 0 1 1 1 0 Control of competence regulator ComK, YlbF/YmcA DUF883 PF05957.13 CCF32509.1 - 0.21 12.2 4.9 25 5.6 0.0 3.7 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF883) COG2 PF06148.11 CCF32509.1 - 0.48 10.5 5.8 2.7 8.1 0.2 3.3 3 1 1 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 Atg14 PF10186.9 CCF32509.1 - 0.58 9.2 4.8 0.93 8.5 4.8 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4164 PF13747.6 CCF32509.1 - 0.91 9.9 10.6 0.48 10.7 4.8 3.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4164) DUF4763 PF15960.5 CCF32509.1 - 3.8 6.8 8.7 7.6 5.8 8.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) DUF4472 PF14739.6 CCF32509.1 - 8.6 7.1 7.4 3.2 8.5 1.4 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4472) Glyco_transf_15 PF01793.16 CCF32510.1 - 0.12 11.6 0.0 0.21 10.8 0.0 1.3 1 0 0 1 1 1 0 Glycolipid 2-alpha-mannosyltransferase Ank_5 PF13857.6 CCF32511.1 - 2.5e-11 43.6 0.0 4.7e-11 42.7 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 CCF32511.1 - 4.7e-07 30.2 0.0 2.2e-06 28.1 0.0 2.1 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 CCF32511.1 - 4.2e-06 27.0 1.0 3.1e-05 24.2 0.1 2.5 3 0 0 3 3 3 1 Ankyrin repeat Ank_2 PF12796.7 CCF32511.1 - 4.8e-06 27.1 0.0 9.2e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CCF32511.1 - 8.4e-05 22.7 0.1 0.00045 20.5 0.0 2.2 2 0 0 2 2 2 1 Ankyrin repeat Trypsin_2 PF13365.6 CCF32512.1 - 0.0045 17.9 0.0 0.011 16.7 0.0 1.7 1 1 0 1 1 1 1 Trypsin-like peptidase domain Peptidase_S3 PF00944.19 CCF32512.1 - 0.054 13.3 0.1 0.096 12.5 0.1 1.3 1 0 0 1 1 1 0 Alphavirus core protein Methyltransf_33 PF10017.9 CCF32513.1 - 2e-05 23.9 0.0 2.1e-05 23.9 0.0 1.0 1 0 0 1 1 1 1 Histidine-specific methyltransferase, SAM-dependent HAD PF12710.7 CCF32514.1 - 1.3e-23 84.3 0.0 1.6e-23 84.1 0.0 1.0 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase UMPH-1 PF05822.12 CCF32514.1 - 0.0085 15.6 0.0 0.021 14.4 0.0 1.6 1 1 1 2 2 2 1 Pyrimidine 5'-nucleotidase (UMPH-1) Hydrolase PF00702.26 CCF32514.1 - 0.024 14.9 0.2 0.38 11.0 0.2 2.1 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase NACHT PF05729.12 CCF32515.1 - 8.5e-09 35.5 0.1 1.9e-08 34.4 0.1 1.6 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 CCF32515.1 - 1.7e-06 28.5 0.9 3.7e-06 27.4 0.1 1.9 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 CCF32515.1 - 0.00011 22.5 0.1 0.00091 19.5 0.0 2.7 2 0 0 2 2 2 1 AAA domain Helo_like_N PF17111.5 CCF32515.1 - 0.003 16.9 0.0 0.0053 16.2 0.0 1.4 1 0 0 1 1 1 1 Fungal N-terminal domain of STAND proteins AAA PF00004.29 CCF32515.1 - 0.0061 17.0 0.0 0.026 15.0 0.0 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 CCF32515.1 - 0.0065 16.4 0.0 0.011 15.7 0.0 1.3 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea NTPase_1 PF03266.15 CCF32515.1 - 0.0075 16.2 0.0 0.014 15.3 0.0 1.4 1 0 0 1 1 1 1 NTPase RNA_helicase PF00910.22 CCF32515.1 - 0.01 16.2 0.0 0.024 15.0 0.0 1.6 1 0 0 1 1 1 0 RNA helicase IstB_IS21 PF01695.17 CCF32515.1 - 0.015 15.1 0.0 0.041 13.6 0.0 1.7 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_33 PF13671.6 CCF32515.1 - 0.021 15.0 0.0 0.061 13.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain APS_kinase PF01583.20 CCF32515.1 - 0.026 14.4 0.0 0.06 13.2 0.0 1.6 1 0 0 1 1 1 0 Adenylylsulphate kinase Cytidylate_kin PF02224.18 CCF32515.1 - 0.028 14.1 0.0 0.1 12.3 0.0 1.9 2 0 0 2 2 2 0 Cytidylate kinase AAA_30 PF13604.6 CCF32515.1 - 0.038 13.7 0.0 0.099 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 CCF32515.1 - 0.066 12.7 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_18 PF13238.6 CCF32515.1 - 0.084 13.4 0.0 0.35 11.4 0.0 2.1 1 0 0 1 1 1 0 AAA domain Phasin_2 PF09361.10 CCF32515.1 - 0.089 13.1 0.8 0.32 11.3 0.3 2.2 2 0 0 2 2 2 0 Phasin protein PIF1 PF05970.14 CCF32515.1 - 0.13 11.4 0.0 0.22 10.7 0.0 1.3 1 0 0 1 1 1 0 PIF1-like helicase NB-ARC PF00931.22 CCF32515.1 - 0.16 11.1 0.0 0.29 10.3 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain AAA_5 PF07728.14 CCF32515.1 - 0.16 11.9 0.0 0.42 10.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 CCF32515.1 - 0.17 11.3 0.0 0.65 9.4 0.0 1.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI MFS_1 PF07690.16 CCF32516.1 - 5.8e-19 68.2 33.4 1.4e-10 40.7 15.9 3.0 1 1 2 3 3 3 3 Major Facilitator Superfamily Fungal_trans PF04082.18 CCF32517.1 - 1.1e-24 87.0 0.0 1.7e-24 86.3 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF32517.1 - 0.012 15.7 10.4 0.023 14.8 10.4 1.4 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Amidohydro_1 PF01979.20 CCF32518.1 - 8.9e-14 51.6 0.0 1.1e-13 51.2 0.0 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 CCF32518.1 - 7.2e-11 42.2 0.1 1.2e-10 41.5 0.1 1.3 1 1 0 1 1 1 1 Amidohydrolase family ketoacyl-synt PF00109.26 CCF32519.1 - 2.5e-50 171.4 0.2 4.7e-50 170.5 0.2 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 CCF32519.1 - 1.2e-43 149.2 0.0 3.6e-43 147.6 0.0 1.9 1 0 0 1 1 1 1 KR domain Acyl_transf_1 PF00698.21 CCF32519.1 - 1.3e-41 143.2 0.0 2.4e-41 142.3 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain PS-DH PF14765.6 CCF32519.1 - 5.1e-41 140.8 0.0 8.1e-41 140.2 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Ketoacyl-synt_C PF02801.22 CCF32519.1 - 1.7e-28 99.0 0.0 4.4e-28 97.7 0.0 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Methyltransf_12 PF08242.12 CCF32519.1 - 2.8e-19 69.7 0.0 6.2e-19 68.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain KAsynt_C_assoc PF16197.5 CCF32519.1 - 3e-13 50.2 0.0 7.4e-13 48.9 0.0 1.6 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Methyltransf_25 PF13649.6 CCF32519.1 - 1.4e-12 48.1 0.0 4.6e-12 46.5 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF32519.1 - 1.8e-11 44.1 0.0 3.6e-11 43.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain adh_short PF00106.25 CCF32519.1 - 9.6e-10 38.2 0.0 6.4e-09 35.5 0.0 2.1 2 0 0 2 2 2 1 short chain dehydrogenase Methyltransf_11 PF08241.12 CCF32519.1 - 2.1e-09 37.9 0.0 5.6e-09 36.5 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF32519.1 - 3.7e-08 33.3 0.0 7.7e-08 32.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Thiolase_N PF00108.23 CCF32519.1 - 2.6e-07 30.3 0.0 5.1e-07 29.3 0.0 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain adh_short_C2 PF13561.6 CCF32519.1 - 1.1e-06 28.5 0.0 4.1e-06 26.5 0.0 1.9 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Ubie_methyltran PF01209.18 CCF32519.1 - 1.7e-05 24.3 0.0 3.7e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PP-binding PF00550.25 CCF32519.1 - 0.00013 22.3 0.3 0.00042 20.6 0.3 2.0 1 0 0 1 1 1 1 Phosphopantetheine attachment site Methyltransf_16 PF10294.9 CCF32519.1 - 0.002 17.9 0.0 0.0039 16.9 0.0 1.4 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_33 PF10017.9 CCF32519.1 - 0.025 13.7 0.0 0.043 13.0 0.0 1.2 1 0 0 1 1 1 0 Histidine-specific methyltransferase, SAM-dependent zf-C3HC4_5 PF17121.5 CCF32520.1 - 0.012 15.4 0.4 0.02 14.7 0.4 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) OPT PF03169.15 CCF32521.1 - 1.2e-171 572.5 50.8 1.4e-171 572.3 50.8 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein PPR_2 PF13041.6 CCF32523.1 - 6.2e-24 83.9 0.0 2.1e-07 31.1 0.0 4.6 4 1 1 5 5 5 4 PPR repeat family PPR PF01535.20 CCF32523.1 - 2.2e-14 52.6 0.0 0.00011 22.2 0.0 5.4 5 1 0 5 5 5 3 PPR repeat PPR_1 PF12854.7 CCF32523.1 - 6.4e-14 51.4 0.0 0.00018 21.1 0.0 5.3 5 0 0 5 5 5 3 PPR repeat PPR_3 PF13812.6 CCF32523.1 - 4.1e-12 46.0 0.0 1.4e-06 28.2 0.0 3.0 3 0 0 3 3 3 2 Pentatricopeptide repeat domain PPR_long PF17177.4 CCF32523.1 - 0.0026 17.2 0.0 0.095 12.1 0.0 2.2 2 0 0 2 2 2 1 Pentacotripeptide-repeat region of PRORP EMP24_GP25L PF01105.24 CCF32524.1 - 3e-54 183.7 0.0 3.4e-54 183.5 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD HXXSHH PF07586.11 CCF32524.1 - 0.03 13.9 0.2 0.045 13.3 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1552) Thymosin PF01290.20 CCF32524.1 - 0.066 12.9 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Thymosin beta-4 family SANT_DAMP1_like PF16282.5 CCF32525.1 - 4.4e-32 110.1 0.4 8.7e-32 109.2 0.4 1.5 1 0 0 1 1 1 1 SANT/Myb-like domain of DAMP1 DUF809 PF05663.11 CCF32525.1 - 0.00084 19.5 0.3 0.00084 19.5 0.3 2.4 1 1 1 2 2 2 1 Protein of unknown function (DUF809) Myb_DNA-bind_6 PF13921.6 CCF32525.1 - 0.081 13.2 0.0 0.3 11.3 0.0 2.1 1 0 0 1 1 1 0 Myb-like DNA-binding domain Pkinase PF00069.25 CCF32527.1 - 1.9e-41 142.2 0.1 9e-23 81.0 0.1 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCF32527.1 - 5.5e-15 55.3 0.2 4.6e-10 39.2 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Aldo_ket_red PF00248.21 CCF32529.1 - 4.9e-17 62.1 0.0 1.3e-07 31.1 0.0 2.1 2 0 0 2 2 2 2 Aldo/keto reductase family GFO_IDH_MocA PF01408.22 CCF32530.1 - 6.1e-17 62.6 0.1 9.8e-17 61.9 0.1 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_3 PF03447.16 CCF32530.1 - 0.035 14.8 0.1 0.063 13.9 0.1 1.3 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain OpuAC PF04069.12 CCF32530.1 - 0.046 13.3 0.1 2.1 7.8 0.1 2.4 2 0 0 2 2 2 0 Substrate binding domain of ABC-type glycine betaine transport system Glyco_hydro_61 PF03443.14 CCF32531.1 - 1.9e-20 73.7 0.0 1.9e-20 73.7 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 fn3 PF00041.21 CCF32531.1 - 0.12 12.8 0.0 0.13 12.6 0.0 1.1 1 0 0 1 1 1 0 Fibronectin type III domain DEAD PF00270.29 CCF32532.1 - 2.5e-39 134.8 0.1 4.3e-39 134.1 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF32532.1 - 1.2e-24 86.8 0.4 2.7e-23 82.4 0.1 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCF32532.1 - 3.5e-08 33.6 0.0 8.1e-08 32.5 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 CCF32532.1 - 0.026 13.9 0.2 0.12 11.7 0.1 1.9 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit DUF4844 PF16133.5 CCF32532.1 - 0.07 13.7 0.6 0.16 12.5 0.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4844) Rpr2 PF04032.16 CCF32533.1 - 8.9e-24 83.6 1.2 1.3e-23 83.1 1.2 1.2 1 0 0 1 1 1 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain HNH_5 PF14279.6 CCF32533.1 - 0.086 12.7 2.5 0.4 10.6 2.7 2.0 1 1 1 2 2 2 0 HNH endonuclease Pyridoxal_deC PF00282.19 CCF32534.1 - 1.8e-65 221.1 0.0 2.7e-65 220.5 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 CCF32534.1 - 0.0012 17.9 0.0 0.0019 17.3 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V CBF PF03914.17 CCF32538.1 - 1.1e-48 165.5 0.2 1.1e-48 165.5 0.2 2.2 2 0 0 2 2 2 1 CBF/Mak21 family DIOX_N PF14226.6 CCF32539.1 - 1.5e-12 48.3 0.0 2.1e-12 47.8 0.0 1.1 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal DUF4328 PF14219.6 CCF32540.1 - 0.0061 16.1 0.8 0.0061 16.1 0.8 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4328) L6_membrane PF05805.12 CCF32540.1 - 0.35 10.4 4.8 0.17 11.5 0.3 2.3 2 1 1 3 3 3 0 L6 membrane protein OPT PF03169.15 CCF32541.1 - 5.4e-134 448.1 51.6 6.1e-134 447.9 51.6 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Spt20 PF12090.8 CCF32541.1 - 1.3 8.6 6.0 2.2 7.9 6.0 1.3 1 0 0 1 1 1 0 Spt20 family MFS_1 PF07690.16 CCF32545.1 - 3.6e-19 68.9 58.9 3.8e-15 55.7 42.9 3.2 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 CCF32545.1 - 7.2e-13 47.8 25.1 1.1e-12 47.2 25.1 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_1 PF07690.16 CCF32546.1 - 9.7e-09 34.6 31.8 9.7e-09 34.6 31.8 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily UNC-93 PF05978.16 CCF32546.1 - 2.7e-06 27.2 2.5 2.7e-06 27.2 2.5 2.5 3 0 0 3 3 3 1 Ion channel regulatory protein UNC-93 CVNH PF08881.10 CCF32547.1 - 7e-11 42.7 0.0 1e-10 42.2 0.0 1.2 1 0 0 1 1 1 1 CVNH domain DUF1968 PF09291.10 CCF32547.1 - 0.019 15.0 0.0 0.034 14.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1968) zf-AN1 PF01428.16 CCF32547.1 - 8 6.7 8.6 6.6 7.0 0.2 3.1 2 1 1 3 3 3 0 AN1-like Zinc finger Fungal_trans_2 PF11951.8 CCF32548.1 - 1e-07 31.2 0.1 6.4e-07 28.5 0.0 2.0 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF32548.1 - 1.9e-05 24.7 4.1 1.9e-05 24.7 4.1 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Beta-lactamase PF00144.24 CCF32549.1 - 2.4e-37 128.9 0.1 3.9e-37 128.2 0.1 1.2 1 0 0 1 1 1 1 Beta-lactamase FAT PF02259.23 CCF32550.1 - 2.9e-132 441.1 10.0 6.8e-132 439.9 10.0 1.7 1 0 0 1 1 1 1 FAT domain DUF3385 PF11865.8 CCF32550.1 - 2.2e-78 261.7 1.1 2.1e-71 239.0 0.2 5.3 4 1 0 4 4 4 2 Domain of unknown function (DUF3385) PI3_PI4_kinase PF00454.27 CCF32550.1 - 3.8e-74 249.7 0.1 8.2e-74 248.6 0.1 1.6 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FRB_dom PF08771.11 CCF32550.1 - 1.8e-45 153.4 0.3 1.8e-45 153.4 0.3 3.7 4 0 0 4 4 3 1 FKBP12-rapamycin binding domain HEAT PF02985.22 CCF32550.1 - 7.5e-15 53.8 23.2 0.00042 20.3 0.0 12.0 12 0 0 12 12 12 3 HEAT repeat FATC PF02260.20 CCF32550.1 - 2.1e-13 49.8 0.1 6.6e-13 48.2 0.1 1.9 1 0 0 1 1 1 1 FATC domain HEAT_2 PF13646.6 CCF32550.1 - 4.7e-13 49.3 17.3 0.00021 21.6 0.0 8.8 8 1 1 9 9 9 2 HEAT repeats HEAT_EZ PF13513.6 CCF32550.1 - 9.1e-12 45.2 14.0 0.0047 17.4 0.2 10.9 8 3 3 11 11 10 2 HEAT-like repeat Vac14_Fab1_bd PF12755.7 CCF32550.1 - 4.7e-06 27.1 0.6 62 4.3 0.0 7.7 7 3 1 8 8 7 0 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 CCF32550.1 - 4.1e-05 23.3 2.8 13 5.3 0.0 5.9 5 1 1 6 6 6 0 CLASP N terminal Cnd1 PF12717.7 CCF32550.1 - 0.00017 21.7 5.3 0.014 15.4 0.0 5.9 4 2 4 8 8 8 2 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 CCF32550.1 - 0.0031 16.2 10.8 0.019 13.5 0.1 4.1 4 0 0 4 4 4 1 Adaptin N terminal region Baculo_PEP_C PF04513.12 CCF32550.1 - 0.014 15.4 0.8 0.14 12.2 0.1 3.1 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Sec7_N PF12783.7 CCF32550.1 - 0.015 15.2 6.6 6.2 6.7 0.0 5.0 4 1 0 4 4 4 0 Guanine nucleotide exchange factor in Golgi transport N-terminal VirDNA-topo-I_N PF09266.10 CCF32550.1 - 0.088 13.0 0.1 0.26 11.5 0.1 1.8 1 0 0 1 1 1 0 Viral DNA topoisomerase I, N-terminal MMS19_C PF12460.8 CCF32550.1 - 0.27 10.3 4.2 9.7 5.2 0.8 3.4 2 1 0 2 2 2 0 RNAPII transcription regulator C-terminal ANAPC3 PF12895.7 CCF32550.1 - 0.89 9.8 7.5 1.7 9.0 0.1 3.8 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 Rtf2 PF04641.12 CCF32551.1 - 7.1e-49 166.5 0.2 8.6e-49 166.2 0.2 1.1 1 0 0 1 1 1 1 Rtf2 RING-finger zf-RING_UBOX PF13445.6 CCF32551.1 - 0.00028 20.8 0.2 0.0017 18.3 0.0 2.2 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_11 PF17123.5 CCF32551.1 - 0.0019 17.9 0.7 0.05 13.4 0.1 2.4 2 0 0 2 2 2 1 RING-like zinc finger Prok-RING_4 PF14447.6 CCF32551.1 - 0.0027 17.5 0.6 0.0084 16.0 0.2 1.9 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 CCF32551.1 - 0.0043 16.9 0.2 0.0072 16.1 0.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CCF32551.1 - 0.0058 16.9 0.2 0.021 15.1 0.2 1.8 1 1 1 2 2 2 1 Ring finger domain zf-RING_5 PF14634.6 CCF32551.1 - 0.0068 16.3 0.1 0.012 15.5 0.1 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-Nse PF11789.8 CCF32551.1 - 0.02 14.7 0.1 0.19 11.6 0.3 2.1 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit Zn-ribbon_8 PF09723.10 CCF32551.1 - 0.076 13.2 0.9 0.17 12.0 0.9 1.5 1 0 0 1 1 1 0 Zinc ribbon domain UPF0547 PF10571.9 CCF32551.1 - 2 8.5 4.7 21 5.3 1.5 2.6 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 PRKCSH-like PF12999.7 CCF32552.1 - 4.7e-41 140.5 5.1 1.4e-22 80.4 0.6 3.0 3 0 0 3 3 3 2 Glucosidase II beta subunit-like PRKCSH_1 PF13015.6 CCF32552.1 - 4.8e-31 107.5 7.5 5.3e-31 107.4 0.7 2.6 3 0 0 3 3 2 1 Glucosidase II beta subunit-like protein PRKCSH PF07915.13 CCF32552.1 - 5.6e-10 40.1 2.3 5.9e-10 40.0 0.7 1.9 2 0 0 2 2 1 1 Glucosidase II beta subunit-like protein Mod_r PF07200.13 CCF32552.1 - 0.00017 21.7 1.5 0.00017 21.7 1.5 2.6 2 1 1 3 3 3 1 Modifier of rudimentary (Mod(r)) protein ATG27 PF09451.10 CCF32552.1 - 0.00026 20.9 0.6 0.00048 20.1 0.6 1.4 1 0 0 1 1 1 1 Autophagy-related protein 27 NPV_P10 PF05531.12 CCF32552.1 - 0.0014 19.1 1.2 0.57 10.7 0.0 2.5 2 0 0 2 2 2 1 Nucleopolyhedrovirus P10 protein Snapin_Pallidin PF14712.6 CCF32552.1 - 0.0027 18.1 2.1 0.3 11.5 0.1 2.5 2 0 0 2 2 2 1 Snapin/Pallidin DUF1664 PF07889.12 CCF32552.1 - 0.0034 17.4 4.1 0.48 10.5 2.3 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF1664) APG17 PF04108.12 CCF32552.1 - 0.0035 16.5 1.2 0.007 15.5 1.2 1.4 1 0 0 1 1 1 1 Autophagy protein Apg17 IATP PF04568.12 CCF32552.1 - 0.012 16.0 7.4 0.076 13.4 2.5 2.7 2 0 0 2 2 2 0 Mitochondrial ATPase inhibitor, IATP Spc29 PF17082.5 CCF32552.1 - 0.019 14.8 2.5 1.7 8.5 0.0 2.4 2 0 0 2 2 2 0 Spindle Pole Component 29 DUF3086 PF11285.8 CCF32552.1 - 0.054 12.6 3.3 1.1 8.3 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3086) Fib_alpha PF08702.10 CCF32552.1 - 0.061 13.5 3.6 0.28 11.4 3.2 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Herpes_UL6 PF01763.16 CCF32552.1 - 0.07 11.6 2.1 0.17 10.4 2.0 1.5 1 1 1 2 2 2 0 Herpesvirus UL6 like TPR_MLP1_2 PF07926.12 CCF32552.1 - 0.18 11.9 19.4 1.2 9.2 7.9 3.2 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein DUF5437 PF17505.2 CCF32552.1 - 0.2 11.7 0.3 4.6 7.3 0.0 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5437) BLOC1_2 PF10046.9 CCF32552.1 - 0.27 11.6 4.4 2.5 8.5 1.4 2.6 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 HIP1_clath_bdg PF16515.5 CCF32552.1 - 0.3 11.7 11.0 0.044 14.4 4.6 2.6 2 1 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Jnk-SapK_ap_N PF09744.9 CCF32552.1 - 0.31 11.2 16.0 2.8 8.2 6.9 3.2 3 0 0 3 3 3 0 JNK_SAPK-associated protein-1 Sec34 PF04136.15 CCF32552.1 - 0.37 10.7 5.4 17 5.3 0.9 3.1 3 0 0 3 3 3 0 Sec34-like family Phage_GP20 PF06810.11 CCF32552.1 - 0.46 10.3 14.2 0.21 11.4 0.3 3.2 3 0 0 3 3 3 0 Phage minor structural protein GP20 ApoO PF09769.9 CCF32552.1 - 0.55 10.2 1.8 1.9 8.5 0.5 2.4 2 0 0 2 2 2 0 Apolipoprotein O Filament PF00038.21 CCF32552.1 - 0.58 9.7 21.5 4.5 6.8 9.4 3.1 2 1 0 3 3 3 0 Intermediate filament protein DUF4200 PF13863.6 CCF32552.1 - 0.91 9.9 22.2 3 8.3 11.9 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4200) Phage_GPO PF05929.11 CCF32552.1 - 1.1 8.8 5.6 1.2 8.7 3.5 2.0 1 1 1 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase DUF641 PF04859.12 CCF32552.1 - 1.4 9.3 9.0 4.7 7.6 6.4 2.4 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) Vps5 PF09325.10 CCF32552.1 - 1.5 8.3 9.7 1.6 8.2 5.8 2.3 2 0 0 2 2 2 0 Vps5 C terminal like CENP-Q PF13094.6 CCF32552.1 - 1.5 9.0 12.1 1.3 9.2 8.2 2.1 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF3450 PF11932.8 CCF32552.1 - 1.7 7.9 11.4 0.36 10.1 4.5 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3450) XhlA PF10779.9 CCF32552.1 - 1.7 8.9 14.8 0.086 13.1 3.2 2.8 3 0 0 3 3 2 0 Haemolysin XhlA Fzo_mitofusin PF04799.13 CCF32552.1 - 2.1 7.9 8.3 2.9 7.4 1.0 2.5 3 0 0 3 3 2 0 fzo-like conserved region SKA2 PF16740.5 CCF32552.1 - 2.3 8.1 10.4 15 5.4 0.5 3.8 3 1 1 4 4 4 0 Spindle and kinetochore-associated protein 2 Nsp1_C PF05064.13 CCF32552.1 - 2.5 7.9 6.0 12 5.8 1.1 2.4 1 1 0 2 2 2 0 Nsp1-like C-terminal region DUF2514 PF10721.9 CCF32552.1 - 3 7.9 11.9 0.48 10.4 6.8 2.1 2 1 1 3 3 2 0 Protein of unknown function (DUF2514) DUF1465 PF07323.12 CCF32552.1 - 3.8 7.3 8.6 5.4 6.9 0.1 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1465) Spc7 PF08317.11 CCF32552.1 - 3.9 6.3 18.2 2.9 6.7 11.2 2.6 2 1 1 3 3 3 0 Spc7 kinetochore protein CREPT PF16566.5 CCF32552.1 - 4 7.6 7.0 47 4.1 0.0 2.7 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour Prefoldin_2 PF01920.20 CCF32552.1 - 4.2 7.4 16.6 3.2 7.7 5.8 3.5 3 1 0 3 3 3 0 Prefoldin subunit DUF4407 PF14362.6 CCF32552.1 - 4.8 6.4 13.5 18 4.6 2.1 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) JIP_LZII PF16471.5 CCF32552.1 - 5.2 7.3 14.3 7.2 6.9 2.9 3.5 3 0 0 3 3 3 0 JNK-interacting protein leucine zipper II GAS PF13851.6 CCF32552.1 - 5.3 6.3 17.9 1.1 8.5 8.4 2.6 3 0 0 3 3 3 0 Growth-arrest specific micro-tubule binding Ax_dynein_light PF10211.9 CCF32552.1 - 6.9 6.6 15.9 0.23 11.4 5.2 2.9 3 0 0 3 3 3 0 Axonemal dynein light chain FlaC_arch PF05377.11 CCF32552.1 - 7.9 7.0 8.2 15 6.1 1.7 3.1 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) NuA4 PF09340.10 CCF32552.1 - 8.6 6.3 11.6 1 9.3 0.2 3.6 3 0 0 3 3 3 0 Histone acetyltransferase subunit NuA4 Spc24 PF08286.11 CCF32552.1 - 8.7 6.6 12.2 0.77 10.0 1.3 3.2 3 1 0 3 3 3 0 Spc24 subunit of Ndc80 GTP-bdg_M PF16360.5 CCF32552.1 - 9.1 7.0 11.7 11 6.7 1.2 3.6 2 1 1 3 3 3 0 GTP-binding GTPase Middle Region GCIP PF13324.6 CCF32553.1 - 2.8e-23 82.9 0.0 5e-23 82.0 0.0 1.3 1 0 0 1 1 1 1 Grap2 and cyclin-D-interacting GYF PF02213.16 CCF32555.1 - 1.1e-18 66.6 0.2 2.3e-18 65.6 0.2 1.6 1 0 0 1 1 1 1 GYF domain GYF_2 PF14237.6 CCF32555.1 - 0.0099 15.7 0.0 0.03 14.1 0.0 1.9 1 0 0 1 1 1 1 GYF domain 2 DUF2605 PF10792.9 CCF32555.1 - 7 6.6 5.7 1 9.4 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2605) TPR_2 PF07719.17 CCF32556.1 - 0.019 15.1 0.0 0.056 13.6 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat Trp_DMAT PF11991.8 CCF32557.1 - 4.3e-92 309.3 0.0 4.9e-92 309.1 0.0 1.0 1 0 0 1 1 1 1 Tryptophan dimethylallyltransferase sCache_2 PF17200.4 CCF32559.1 - 0.14 12.0 0.1 0.3 10.9 0.1 1.5 2 0 0 2 2 2 0 Single Cache domain 2 dCache_2 PF08269.11 CCF32559.1 - 0.21 10.7 0.0 0.59 9.2 0.0 1.6 2 0 0 2 2 2 0 Cache domain Pro_isomerase PF00160.21 CCF32560.1 - 6.5e-41 140.2 0.0 1.4e-40 139.1 0.0 1.6 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD HSF_DNA-bind PF00447.17 CCF32561.1 - 1.4e-28 99.4 0.4 2.7e-28 98.4 0.4 1.5 1 0 0 1 1 1 1 HSF-type DNA-binding Ets PF00178.22 CCF32561.1 - 0.04 14.4 0.0 0.097 13.1 0.0 1.6 1 0 0 1 1 1 0 Ets-domain Cullin_binding PF03556.15 CCF32562.1 - 4e-34 117.6 5.1 5.3e-34 117.2 5.1 1.1 1 0 0 1 1 1 1 Cullin binding Ribosomal_S6 PF01250.17 CCF32563.1 - 3.2e-23 81.8 0.0 3.8e-23 81.6 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S6 SQS_PSY PF00494.19 CCF32564.1 - 3.7e-60 203.6 1.7 4.5e-60 203.4 1.7 1.1 1 0 0 1 1 1 1 Squalene/phytoene synthase SNF2_N PF00176.23 CCF32565.1 - 4.7e-75 252.5 0.0 6.8e-75 252.0 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain HIRAN PF08797.11 CCF32565.1 - 2.4e-25 88.3 0.0 4.7e-25 87.4 0.0 1.5 1 0 0 1 1 1 1 HIRAN domain Helicase_C PF00271.31 CCF32565.1 - 8.3e-16 58.3 0.0 2.5e-15 56.8 0.0 1.9 2 0 0 2 2 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCF32565.1 - 8.2e-07 29.2 0.0 2.1e-06 27.8 0.0 1.8 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit zf-C3HC4 PF00097.25 CCF32565.1 - 2.1e-06 27.5 11.3 3.9e-06 26.6 11.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CCF32565.1 - 9.1e-05 22.7 10.4 0.00023 21.4 10.4 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 CCF32565.1 - 0.00015 21.6 8.4 0.00027 20.8 8.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) DEAD PF00270.29 CCF32565.1 - 0.00047 20.0 0.0 0.0011 18.8 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase zf-C3HC4_2 PF13923.6 CCF32565.1 - 0.0011 18.8 11.1 0.0023 17.7 11.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CCF32565.1 - 0.0073 16.3 7.6 0.015 15.3 7.6 1.6 1 0 0 1 1 1 1 RING-type zinc-finger ERCC3_RAD25_C PF16203.5 CCF32565.1 - 0.02 14.1 0.2 0.046 12.9 0.2 1.5 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase zf-RING_5 PF14634.6 CCF32565.1 - 0.043 13.8 9.7 0.13 12.3 9.8 1.8 1 1 0 1 1 1 0 zinc-RING finger domain UBA_4 PF14555.6 CCF32565.1 - 0.082 12.7 0.0 0.24 11.2 0.0 1.8 1 0 0 1 1 1 0 UBA-like domain Prok-RING_4 PF14447.6 CCF32565.1 - 0.096 12.6 7.7 0.55 10.1 8.0 2.0 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 CCF32565.1 - 4.3 7.6 8.9 9.3 6.5 8.9 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING PX PF00787.24 CCF32568.1 - 3.2e-21 75.4 0.0 4.5e-21 75.0 0.0 1.2 1 0 0 1 1 1 1 PX domain p450 PF00067.22 CCF32569.1 - 4.2e-24 85.1 0.0 5.8e-24 84.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Fungal_trans_2 PF11951.8 CCF32570.1 - 7.4e-16 57.9 0.1 9.6e-16 57.6 0.1 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF32570.1 - 0.00049 20.2 7.0 0.00049 20.2 7.0 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PALP PF00291.25 CCF32571.1 - 2.4e-22 79.7 0.3 2.4e-22 79.7 0.3 1.5 2 0 0 2 2 2 1 Pyridoxal-phosphate dependent enzyme Methyltransf_28 PF02636.17 CCF32572.1 - 5.3e-44 150.8 0.0 9e-44 150.1 0.0 1.3 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase PRMT5 PF05185.16 CCF32572.1 - 0.0013 18.6 0.0 0.0028 17.5 0.0 1.5 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase FAD_SOX PF18371.1 CCF32572.1 - 0.2 12.0 0.0 0.79 10.1 0.0 2.1 2 0 0 2 2 2 0 Flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidase tRNA-synt_2c PF01411.19 CCF32573.1 - 1.6e-212 706.9 0.0 1.6e-212 706.9 0.0 1.3 2 0 0 2 2 2 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 CCF32573.1 - 2.4e-17 62.7 0.4 7.1e-17 61.2 0.4 1.9 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.19 CCF32573.1 - 7.9e-12 45.8 3.1 2.9e-11 43.9 3.1 2.1 1 0 0 1 1 1 1 DHHA1 domain CBP_BcsQ PF06564.12 CCF32573.1 - 0.17 11.3 0.1 0.3 10.5 0.1 1.3 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsQ Mitoc_L55 PF09776.9 CCF32573.1 - 0.43 10.3 2.4 4.8 6.9 0.1 3.0 3 0 0 3 3 3 0 Mitochondrial ribosomal protein L55 NPA PF16469.5 CCF32573.1 - 2.4 8.8 6.6 0.39 11.3 1.0 2.4 2 0 0 2 2 2 0 Nematode polyprotein allergen ABA-1 CD20 PF04103.15 CCF32575.1 - 2.2 8.3 13.5 2.5 8.2 5.0 2.6 2 1 0 2 2 2 0 CD20-like family Caleosin PF05042.13 CCF32576.1 - 7.8e-79 263.5 0.1 9.6e-79 263.2 0.1 1.1 1 0 0 1 1 1 1 Caleosin related protein Glyco_hydro_3 PF00933.21 CCF32578.1 - 2.7e-25 89.4 0.0 4e-25 88.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain MaoC_dehydratas PF01575.19 CCF32579.1 - 2.4e-06 27.1 0.0 3.6e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 MaoC like domain MaoC_dehydrat_N PF13452.6 CCF32579.1 - 0.021 14.9 0.0 2.8 8.1 0.0 2.3 2 0 0 2 2 2 0 N-terminal half of MaoC dehydratase eRF1_2 PF03464.15 CCF32580.1 - 3.5e-46 156.8 0.0 5.8e-46 156.1 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 CCF32580.1 - 7.8e-41 139.1 0.6 1.5e-40 138.2 0.6 1.5 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.15 CCF32580.1 - 7.1e-22 77.8 0.0 1.2e-21 77.1 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 1 baeRF_family10 PF18854.1 CCF32580.1 - 9.8e-11 42.1 0.3 2.7e-10 40.6 0.0 1.8 2 0 0 2 2 2 1 Bacterial archaeo-eukaryotic release factor family 10 acVLRF1 PF18859.1 CCF32580.1 - 8.6e-10 39.0 0.0 1.4e-09 38.3 0.0 1.3 1 0 0 1 1 1 1 Actinobacteria/chloroflexi VLRF1 release factor DUF1770 PF08589.10 CCF32581.1 - 8.3e-37 126.1 1.1 1.1e-36 125.8 1.1 1.1 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1770) Glyco_hydro_18 PF00704.28 CCF32583.1 - 2.4e-81 273.9 0.4 3e-81 273.6 0.4 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Glyco_hydro_85 PF03644.13 CCF32583.1 - 0.11 11.9 0.0 0.16 11.4 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 85 LRR_6 PF13516.6 CCF32584.1 - 3.1e-09 36.2 2.3 0.13 12.4 0.0 6.7 7 0 0 7 7 7 3 Leucine Rich repeat LRR_4 PF12799.7 CCF32584.1 - 8.8e-06 26.0 14.8 0.78 10.3 0.0 5.8 6 2 0 6 6 6 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 CCF32584.1 - 0.00049 20.3 0.0 14 6.7 0.1 5.5 5 0 0 5 5 5 1 Leucine Rich Repeat LRR_8 PF13855.6 CCF32584.1 - 0.037 13.8 10.6 16 5.3 0.5 5.4 4 2 0 4 4 4 0 Leucine rich repeat zf-H2C2_2 PF13465.6 CCF32585.1 - 2.7e-06 27.6 9.8 5.2e-06 26.6 1.3 3.3 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_6 PF13912.6 CCF32585.1 - 5.5e-06 26.3 0.7 0.011 15.7 0.0 2.3 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 CCF32585.1 - 9.7e-06 25.8 0.5 9.7e-06 25.8 0.5 3.8 3 1 0 3 3 3 1 Zinc finger, C2H2 type FOXP-CC PF16159.5 CCF32585.1 - 2e-05 25.2 6.0 0.25 12.0 0.0 3.5 2 1 1 3 3 3 2 FOXP coiled-coil domain zf-C2H2_4 PF13894.6 CCF32585.1 - 0.00033 21.3 7.5 0.0039 17.9 0.4 3.4 3 0 0 3 3 3 1 C2H2-type zinc finger DUF5595 PF18077.1 CCF32585.1 - 0.058 13.5 0.7 0.15 12.2 0.7 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF5595) zf-H2C2_5 PF13909.6 CCF32585.1 - 0.29 10.9 2.8 0.62 9.9 0.1 2.3 2 0 0 2 2 2 0 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.8 CCF32585.1 - 0.62 10.4 3.9 2.6 8.5 0.3 3.0 3 1 0 3 3 3 0 Zinc-finger double-stranded RNA-binding Sina PF03145.16 CCF32585.1 - 4.1 7.3 9.4 4.8 7.1 1.6 2.9 2 1 1 3 3 3 0 Seven in absentia protein family Fe_hyd_lg_C PF02906.14 CCF32587.1 - 7.3e-51 173.2 0.0 2e-50 171.7 0.0 1.7 1 1 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain SUZ PF12752.7 CCF32588.1 - 2.3e-05 25.0 5.1 2.3e-05 25.0 5.1 3.8 2 1 1 3 3 3 1 SUZ domain DUF4658 PF15555.6 CCF32591.1 - 0.054 13.6 0.1 0.13 12.4 0.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4658) SAT PF16073.5 CCF32591.1 - 0.15 11.8 0.2 0.19 11.4 0.2 1.1 1 0 0 1 1 1 0 Starter unit:ACP transacylase in aflatoxin biosynthesis SQS_PSY PF00494.19 CCF32592.1 - 2.4e-36 125.6 0.0 4.2e-36 124.8 0.0 1.4 2 0 0 2 2 2 1 Squalene/phytoene synthase Cnl2_NKP2 PF09447.10 CCF32592.1 - 0.066 13.4 0.2 0.19 11.9 0.1 1.8 2 0 0 2 2 2 0 Cnl2/NKP2 family protein Glyco_hydro_65m PF03632.15 CCF32592.1 - 0.15 10.9 0.1 0.23 10.3 0.1 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 65 central catalytic domain RmlD_sub_bind PF04321.17 CCF32593.1 - 7e-16 58.2 0.0 2.8e-15 56.2 0.0 1.8 1 1 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.21 CCF32593.1 - 1e-12 48.0 0.0 1.8e-12 47.2 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CCF32593.1 - 0.00043 19.8 0.0 0.0095 15.4 0.0 2.4 2 1 1 3 3 3 2 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 CCF32593.1 - 0.0011 18.2 0.0 0.0018 17.5 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 CCF32593.1 - 0.018 14.1 0.1 0.069 12.1 0.0 1.8 1 1 1 2 2 2 0 3-beta hydroxysteroid dehydrogenase/isomerase family C2-set_2 PF08205.12 CCF32593.1 - 0.05 13.7 0.2 0.11 12.5 0.2 1.5 1 1 0 1 1 1 0 CD80-like C2-set immunoglobulin domain DUF753 PF05444.12 CCF32593.1 - 0.11 12.5 0.6 0.26 11.2 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF753) DnaJ PF00226.31 CCF32594.1 - 5.5e-28 96.9 1.1 8.8e-28 96.2 1.1 1.3 1 0 0 1 1 1 1 DnaJ domain Sigma70_ner PF04546.13 CCF32594.1 - 1.5 8.7 4.7 4.6 7.1 0.0 2.1 2 0 0 2 2 2 0 Sigma-70, non-essential region Arm PF00514.23 CCF32595.1 - 3.1e-97 316.0 16.1 3.8e-13 49.0 0.3 8.4 8 0 0 8 8 8 8 Armadillo/beta-catenin-like repeat IBB PF01749.20 CCF32595.1 - 2.9e-24 85.3 0.5 2.9e-24 85.3 0.5 1.8 2 0 0 2 2 1 1 Importin beta binding domain Arm_3 PF16186.5 CCF32595.1 - 1.7e-23 81.9 5.8 2.5e-23 81.4 4.6 1.9 2 0 0 2 2 2 1 Atypical Arm repeat HEAT_EZ PF13513.6 CCF32595.1 - 3.5e-22 78.5 11.6 7.6e-09 35.9 0.1 6.6 6 1 1 7 7 7 4 HEAT-like repeat HEAT_2 PF13646.6 CCF32595.1 - 2.5e-19 69.5 0.1 1.5e-08 34.9 0.0 5.3 1 1 3 5 5 5 4 HEAT repeats HEAT PF02985.22 CCF32595.1 - 1.3e-18 65.4 3.0 1.7e-05 24.6 0.0 7.1 8 0 0 8 8 8 4 HEAT repeat Arm_2 PF04826.13 CCF32595.1 - 8.4e-08 32.0 0.0 0.027 13.9 0.0 4.0 2 1 2 4 4 4 3 Armadillo-like V-ATPase_H_C PF11698.8 CCF32595.1 - 4.3e-05 23.6 0.0 2.1 8.5 0.0 4.4 3 2 1 4 4 4 2 V-ATPase subunit H Adaptin_N PF01602.20 CCF32595.1 - 4.4e-05 22.2 0.0 0.0024 16.5 0.0 2.5 1 1 0 2 2 2 1 Adaptin N terminal region Cnd1 PF12717.7 CCF32595.1 - 0.00037 20.6 0.0 0.72 9.9 0.0 3.0 3 1 0 3 3 2 2 non-SMC mitotic condensation complex subunit 1 HEAT_PBS PF03130.16 CCF32595.1 - 0.00075 19.9 0.2 1.7 9.5 0.0 4.5 4 0 0 4 4 4 1 PBS lyase HEAT-like repeat NopRA1 PF16201.5 CCF32595.1 - 0.014 14.9 0.0 4.6 6.8 0.0 4.0 2 2 2 4 4 4 0 Nucleolar pre-ribosomal-associated protein 1 RICTOR_V PF14668.6 CCF32595.1 - 0.038 14.2 4.9 3.5 7.9 0.1 4.7 3 2 3 6 6 6 0 Rapamycin-insensitive companion of mTOR, domain 5 Glycos_trans_3N PF02885.17 CCF32595.1 - 0.12 12.2 0.0 7.4 6.5 0.0 3.1 3 0 0 3 3 3 0 Glycosyl transferase family, helical bundle domain NUSAP PF16006.5 CCF32595.1 - 0.7 9.6 2.2 1 9.1 2.2 1.2 1 0 0 1 1 1 0 Nucleolar and spindle-associated protein Med5 PF08689.10 CCF32596.1 - 3.4e-96 323.2 0.0 4.1e-95 319.6 0.0 2.4 1 1 0 1 1 1 1 Mediator complex subunit Med5 SSF PF00474.17 CCF32596.1 - 0.004 16.1 0.2 0.0068 15.3 0.2 1.3 1 0 0 1 1 1 1 Sodium:solute symporter family LigB PF02900.18 CCF32597.1 - 4.7e-07 29.1 0.0 1.3e-06 27.8 0.0 1.8 1 1 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase NCKAP5 PF15246.6 CCF32598.1 - 0.014 15.0 1.3 0.017 14.7 1.3 1.1 1 0 0 1 1 1 0 Nck-associated protein 5, Peripheral clock protein HSDR_N_2 PF13588.6 CCF32599.1 - 0.0014 18.6 0.0 0.0019 18.2 0.0 1.1 1 0 0 1 1 1 1 Type I restriction enzyme R protein N terminus (HSDR_N) RNase_II_C_S1 PF18614.1 CCF32599.1 - 0.11 12.5 0.3 0.16 12.0 0.3 1.3 1 0 0 1 1 1 0 RNase II-type exonuclease C-terminal S1 domain Fungal_trans_2 PF11951.8 CCF32600.1 - 2.1e-05 23.5 4.5 2.1e-05 23.5 4.5 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain Peptidase_M24 PF00557.24 CCF32602.1 - 3.7e-49 167.3 0.0 5.7e-49 166.6 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 CCF32602.1 - 8.3e-39 132.1 0.0 1.3e-38 131.5 0.0 1.3 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain HLH PF00010.26 CCF32603.1 - 5.4e-09 35.9 0.1 1e-08 35.0 0.1 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain LysM PF01476.20 CCF32604.1 - 0.0018 18.3 0.0 0.003 17.6 0.0 1.4 1 0 0 1 1 1 1 LysM domain TRP PF06011.12 CCF32605.1 - 2.7e-110 369.0 18.1 5.1e-110 368.1 18.1 1.4 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 CCF32605.1 - 6e-38 130.3 0.1 9.2e-38 129.7 0.1 1.3 1 0 0 1 1 1 1 ML-like domain Semialdhyde_dhC PF02774.18 CCF32606.1 - 7e-30 104.5 0.1 2.3e-25 89.7 0.0 2.2 1 1 1 2 2 2 2 Semialdehyde dehydrogenase, dimerisation domain Semialdhyde_dh PF01118.24 CCF32606.1 - 4.1e-22 78.9 0.0 1.8e-20 73.6 0.0 2.8 2 1 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.20 CCF32606.1 - 0.0054 16.9 0.0 0.015 15.5 0.0 1.7 2 0 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus SET_assoc PF11767.8 CCF32606.1 - 0.084 12.5 0.0 0.19 11.4 0.0 1.5 1 0 0 1 1 1 0 Histone lysine methyltransferase SET associated dCMP_cyt_deam_1 PF00383.23 CCF32607.1 - 7.9e-08 32.1 0.0 2e-07 30.8 0.0 1.7 1 1 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 CCF32607.1 - 0.014 15.1 0.1 0.028 14.2 0.1 1.4 1 0 0 1 1 1 0 MafB19-like deaminase Fungal_trans PF04082.18 CCF32608.1 - 1.1e-22 80.4 0.0 2e-22 79.5 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF32608.1 - 3.3e-07 30.3 12.6 6.2e-07 29.4 12.6 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Haem_oxygenas_2 PF14518.6 CCF32608.1 - 0.063 13.0 0.2 0.12 12.1 0.2 1.4 1 0 0 1 1 1 0 Iron-containing redox enzyme BatA PF07584.11 CCF32608.1 - 0.11 12.9 3.0 40 4.7 0.2 4.4 4 0 0 4 4 4 0 Aerotolerance regulator N-terminal Aminotran_1_2 PF00155.21 CCF32611.1 - 8.7e-08 31.7 0.0 2.1e-05 23.9 0.0 2.1 2 0 0 2 2 2 2 Aminotransferase class I and II Ribosomal_L4 PF00573.22 CCF32612.1 - 1.6e-33 116.0 0.5 2.1e-33 115.6 0.5 1.2 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.6 CCF32612.1 - 5.9e-27 93.5 1.9 1.4e-26 92.3 1.9 1.7 1 0 0 1 1 1 1 60S ribosomal protein L4 C-terminal domain AA_permease_2 PF13520.6 CCF32613.1 - 2.9e-42 145.0 37.6 4.2e-42 144.5 37.6 1.2 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CCF32613.1 - 5.2e-22 78.1 22.9 5.2e-22 78.1 22.9 2.2 2 0 0 2 2 2 2 Amino acid permease Glyco_hydro_76 PF03663.14 CCF32615.1 - 2.2e-155 517.7 11.7 2.6e-155 517.5 11.7 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 CCF32615.1 - 0.0013 17.9 5.9 0.039 13.0 0.1 2.9 3 0 0 3 3 3 2 Glycosyl Hydrolase Family 88 Dak1 PF02733.17 CCF32616.1 - 3.3e-104 348.1 4.1 4.2e-104 347.8 4.1 1.1 1 0 0 1 1 1 1 Dak1 domain SRAP PF02586.14 CCF32617.1 - 6.7e-76 254.7 0.0 1.1e-75 253.9 0.0 1.3 1 0 0 1 1 1 1 SOS response associated peptidase (SRAP) RNA_pol_Rpb1_1 PF04997.12 CCF32618.1 - 5.3e-85 285.5 0.1 9.9e-85 284.6 0.1 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.17 CCF32618.1 - 5.5e-78 262.1 0.2 9.6e-78 261.3 0.2 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 CCF32618.1 - 4e-73 245.1 0.0 7.3e-73 244.2 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 CCF32618.1 - 2.4e-39 134.8 0.0 7.9e-39 133.1 0.0 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 CCF32618.1 - 8.9e-29 99.6 0.1 3.1e-28 97.8 0.1 2.0 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 VWA PF00092.28 CCF32620.1 - 0.046 14.0 0.0 0.098 12.9 0.0 1.6 1 1 0 1 1 1 0 von Willebrand factor type A domain MarB PF13999.6 CCF32620.1 - 0.065 13.1 0.3 0.41 10.5 0.0 2.3 2 0 0 2 2 2 0 MarB protein DEAD PF00270.29 CCF32621.1 - 1.1e-46 158.8 0.0 4.3e-44 150.4 0.0 2.1 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF32621.1 - 3.6e-11 43.4 0.0 3.5e-09 37.0 0.0 2.7 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCF32621.1 - 3.9e-08 33.5 0.0 5.8e-08 32.9 0.0 1.2 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_RecD PF05127.14 CCF32621.1 - 0.0014 18.5 0.0 0.0024 17.7 0.0 1.3 1 0 0 1 1 1 1 Helicase AAA_30 PF13604.6 CCF32621.1 - 0.022 14.5 0.0 0.079 12.7 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_11 PF13086.6 CCF32621.1 - 0.064 13.0 0.1 7.9 6.2 0.0 2.3 1 1 1 2 2 2 0 AAA domain AAA_19 PF13245.6 CCF32621.1 - 0.1 12.9 0.0 0.23 11.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.9 CCF32621.1 - 0.13 11.5 0.1 0.32 10.2 0.1 1.6 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.6 CCF32621.1 - 0.27 11.5 1.3 1.5 9.1 1.3 2.1 1 1 0 1 1 1 0 AAA domain A_deaminase PF00962.22 CCF32623.1 - 1.1e-34 120.2 0.0 1.4e-34 119.9 0.0 1.0 1 0 0 1 1 1 1 Adenosine/AMP deaminase TatD_DNase PF01026.21 CCF32623.1 - 0.027 13.9 0.0 0.038 13.4 0.0 1.2 1 0 0 1 1 1 0 TatD related DNase Tom22 PF04281.13 CCF32625.1 - 6.2e-44 149.1 0.0 7.5e-44 148.9 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom22 MFS_1 PF07690.16 CCF32626.1 - 4.4e-10 39.0 20.0 5.4e-10 38.7 20.0 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF4291 PF14124.6 CCF32627.1 - 5.3e-65 218.7 0.0 7.8e-65 218.1 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4291) Git3 PF11710.8 CCF32628.1 - 1.1e-15 57.9 7.3 1.1e-15 57.9 7.3 1.7 2 1 0 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 7tm_1 PF00001.21 CCF32628.1 - 1.3e-06 27.9 6.2 2.3e-06 27.1 6.2 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Dicty_CAR PF05462.11 CCF32628.1 - 0.0042 16.3 7.2 0.0078 15.4 7.2 1.4 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor LptF_LptG PF03739.14 CCF32628.1 - 0.056 12.3 0.1 0.056 12.3 0.1 2.5 2 0 0 2 2 2 0 Lipopolysaccharide export system permease LptF/LptG Abhydrolase_1 PF00561.20 CCF32629.1 - 1.1e-23 84.2 0.2 5.5e-23 81.9 0.2 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydro_lipase PF04083.16 CCF32629.1 - 2.9e-21 74.8 0.1 6.2e-21 73.7 0.1 1.6 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Hydrolase_4 PF12146.8 CCF32629.1 - 1.5e-05 24.4 0.0 0.002 17.4 0.0 2.4 1 1 0 1 1 1 1 Serine aminopeptidase, S33 FSH1 PF03959.13 CCF32629.1 - 0.00011 21.9 0.1 0.14 11.8 0.0 2.2 2 0 0 2 2 2 2 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.16 CCF32629.1 - 0.17 11.7 0.1 25 4.6 0.0 2.3 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Pet191_N PF10203.9 CCF32630.1 - 8.3e-28 96.5 5.5 1.1e-27 96.1 5.5 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein PET191 CX9C PF16860.5 CCF32630.1 - 0.012 15.5 5.7 0.31 11.1 0.5 2.6 2 1 1 3 3 3 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, COBRA PF04833.15 CCF32630.1 - 0.062 13.2 0.4 0.085 12.7 0.4 1.3 1 0 0 1 1 1 0 COBRA-like protein PAN_3 PF08277.12 CCF32630.1 - 0.096 12.5 0.6 0.17 11.7 0.6 1.4 1 0 0 1 1 1 0 PAN-like domain MFS_1 PF07690.16 CCF32631.1 - 2.7e-34 118.6 74.2 2.5e-28 99.0 44.4 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Alpha_GJ PF03229.13 CCF32631.1 - 0.04 14.5 1.8 0.081 13.5 0.9 2.0 2 0 0 2 2 2 0 Alphavirus glycoprotein J AIM24 PF01987.17 CCF32632.1 - 2.5e-52 177.6 0.0 3e-52 177.3 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial biogenesis AIM24 Kinesin PF00225.23 CCF32633.1 - 6.7e-81 271.8 0.0 6.7e-81 271.8 0.0 1.7 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 CCF32633.1 - 1.6e-20 73.5 0.0 3.3e-20 72.5 0.0 1.6 1 0 0 1 1 1 1 Microtubule binding HHH_3 PF12836.7 CCF32633.1 - 0.00018 21.7 0.2 0.00083 19.6 0.0 2.2 2 0 0 2 2 2 1 Helix-hairpin-helix motif HHH_5 PF14520.6 CCF32633.1 - 0.031 14.9 0.0 11 6.7 0.0 2.8 2 0 0 2 2 2 0 Helix-hairpin-helix domain MerR-DNA-bind PF09278.11 CCF32633.1 - 0.15 12.6 2.1 1.7 9.3 0.4 3.1 2 1 1 3 3 3 0 MerR, DNA binding Methyltransf_32 PF13679.6 CCF32634.1 - 1.4e-20 73.9 0.0 2.3e-20 73.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Syntaxin-6_N PF09177.11 CCF32635.1 - 1.1e-26 93.3 0.2 5.1e-26 91.1 0.0 2.0 2 0 0 2 2 2 1 Syntaxin 6, N-terminal SNARE PF05739.19 CCF32635.1 - 0.00031 20.7 1.0 0.00071 19.5 1.0 1.6 1 0 0 1 1 1 1 SNARE domain UPF0242 PF06785.11 CCF32635.1 - 0.041 14.0 0.0 8.4 6.4 0.0 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Use1 PF09753.9 CCF32635.1 - 0.08 12.7 0.0 0.12 12.1 0.0 1.4 1 1 0 1 1 1 0 Membrane fusion protein Use1 ATG16 PF08614.11 CCF32635.1 - 0.22 11.7 5.1 3.9 7.6 1.8 2.2 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) NPV_P10 PF05531.12 CCF32635.1 - 0.27 11.7 1.3 29 5.2 0.2 3.2 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein TBCA PF02970.16 CCF32635.1 - 0.41 11.0 4.4 0.33 11.3 0.8 2.5 2 2 1 3 3 3 0 Tubulin binding cofactor A Vps5 PF09325.10 CCF32635.1 - 0.46 10.0 2.6 1.9 8.0 0.2 2.7 3 0 0 3 3 3 0 Vps5 C terminal like GLE1 PF07817.13 CCF32636.1 - 3.7e-65 219.6 0.0 6.5e-65 218.8 0.0 1.4 1 0 0 1 1 1 1 GLE1-like protein Arrestin_C PF02752.22 CCF32637.1 - 3.8e-15 56.5 0.4 3.4e-14 53.4 0.1 2.2 2 1 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain adh_short PF00106.25 CCF32638.1 - 4.9e-25 88.1 0.0 3.1e-19 69.2 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCF32638.1 - 1.5e-17 64.0 0.0 1.3e-16 60.9 0.0 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF32638.1 - 0.00037 20.5 0.0 0.0006 19.8 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF32638.1 - 0.0062 16.0 0.0 0.0089 15.5 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CCF32638.1 - 0.034 13.6 0.0 0.046 13.1 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase p450 PF00067.22 CCF32640.1 - 7.6e-76 255.7 0.0 9.6e-76 255.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 LptF_LptG PF03739.14 CCF32640.1 - 0.26 10.1 1.0 0.43 9.4 1.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG DUF3074 PF11274.8 CCF32641.1 - 4e-45 154.1 0.3 5.8e-45 153.5 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3074) DUF1635 PF07795.11 CCF32642.1 - 0.0037 17.2 0.4 0.0068 16.3 0.4 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1635) CENP-H PF05837.12 CCF32642.1 - 0.43 11.0 6.0 0.18 12.2 2.7 2.1 2 0 0 2 2 2 0 Centromere protein H (CENP-H) Fib_alpha PF08702.10 CCF32642.1 - 0.57 10.4 6.7 0.15 12.3 2.6 2.0 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Glutaredoxin PF00462.24 CCF32643.1 - 1.9e-18 66.4 0.0 3.4e-17 62.4 0.0 2.3 2 0 0 2 2 2 1 Glutaredoxin Thioredoxin PF00085.20 CCF32643.1 - 5.5e-14 52.0 0.0 1.3e-13 50.9 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 CCF32643.1 - 0.011 16.0 0.0 3.3 8.1 0.0 2.6 1 1 1 2 2 2 0 Thioredoxin-like HyaE PF07449.11 CCF32643.1 - 0.012 15.6 0.0 0.057 13.4 0.0 2.0 2 1 0 2 2 2 0 Hydrogenase-1 expression protein HyaE Thioredoxin_3 PF13192.6 CCF32643.1 - 0.093 12.8 0.1 0.38 10.8 0.0 2.1 2 0 0 2 2 2 0 Thioredoxin domain Zds_C PF08632.10 CCF32644.1 - 2.8e-28 97.4 1.2 4.9e-28 96.6 1.2 1.4 1 0 0 1 1 1 1 Activator of mitotic machinery Cdc14 phosphatase activation C-term DUF2433 PF10360.9 CCF32645.1 - 7.4e-50 168.2 0.1 1.1e-49 167.6 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2433) Metallophos PF00149.28 CCF32645.1 - 0.00073 20.1 0.0 0.0023 18.5 0.0 1.9 2 1 0 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CCF32645.1 - 0.013 15.7 0.0 0.038 14.2 0.0 1.8 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain Ubie_methyltran PF01209.18 CCF32646.1 - 1.5e-79 266.6 0.0 3.6e-79 265.4 0.0 1.5 1 1 1 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 CCF32646.1 - 7.2e-16 58.7 0.0 1.4e-15 57.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF32646.1 - 1.3e-14 54.6 0.0 5e-14 52.7 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF32646.1 - 2.1e-12 47.6 0.0 3.4e-12 47.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF32646.1 - 1.1e-10 41.5 0.0 1.4e-10 41.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF32646.1 - 2.1e-08 34.2 0.0 3e-08 33.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 CCF32646.1 - 0.0068 16.3 0.0 0.033 14.0 0.0 2.1 3 0 0 3 3 3 1 Hypothetical methyltransferase ADH_zinc_N PF00107.26 CCF32646.1 - 0.12 12.4 0.0 0.25 11.3 0.0 1.6 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Aminotran_4 PF01063.19 CCF32648.1 - 1.8e-32 113.0 0.0 2.4e-32 112.6 0.0 1.2 1 0 0 1 1 1 1 Amino-transferase class IV DUF4148 PF13663.6 CCF32648.1 - 0.27 11.4 0.8 0.57 10.4 0.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4148) MFS_1 PF07690.16 CCF32649.1 - 4.7e-33 114.6 27.0 4.7e-33 114.6 27.0 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily DSRB PF10781.9 CCF32649.1 - 0.00052 19.6 0.5 0.0013 18.4 0.0 1.8 2 0 0 2 2 2 1 Dextransucrase DSRB TMEM40 PF15817.5 CCF32651.1 - 0.048 13.4 0.0 0.06 13.1 0.0 1.1 1 0 0 1 1 1 0 Transmembrane protein 40 family PAS_3 PF08447.12 CCF32652.1 - 4.5e-14 52.5 0.0 9.8e-14 51.4 0.0 1.5 1 0 0 1 1 1 1 PAS fold PAS PF00989.25 CCF32652.1 - 1.4e-07 31.5 0.1 6.1e-07 29.4 0.0 1.9 2 0 0 2 2 2 1 PAS fold PAS_9 PF13426.7 CCF32652.1 - 0.00015 22.0 0.1 0.00039 20.6 0.0 1.7 2 0 0 2 2 2 1 PAS domain PAS_11 PF14598.6 CCF32652.1 - 0.0011 19.0 0.0 0.0042 17.2 0.0 1.8 2 0 0 2 2 2 1 PAS domain PAS_4 PF08448.10 CCF32652.1 - 0.0018 18.5 0.0 0.0035 17.6 0.0 1.5 1 0 0 1 1 1 1 PAS fold DUF4428 PF14471.6 CCF32652.1 - 0.049 13.6 1.3 0.22 11.5 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4428) PAS_8 PF13188.7 CCF32652.1 - 0.18 11.9 0.0 0.55 10.3 0.0 1.8 1 0 0 1 1 1 0 PAS domain AAA_23 PF13476.6 CCF32653.1 - 4e-35 122.1 1.8 4e-35 122.1 1.8 4.4 1 1 2 3 3 3 1 AAA domain SMC_N PF02463.19 CCF32653.1 - 4.5e-09 36.1 0.1 4.5e-09 36.1 0.1 2.3 2 1 1 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 CCF32653.1 - 0.00063 19.6 2.3 0.00068 19.5 0.0 2.2 2 1 1 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CCF32653.1 - 0.00075 19.2 0.0 0.0016 18.1 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_13 PF13166.6 CCF32653.1 - 0.037 12.7 0.0 0.037 12.7 0.0 4.1 1 1 1 3 3 3 0 AAA domain AAA_16 PF13191.6 CCF32653.1 - 0.041 14.3 0.0 0.041 14.3 0.0 3.5 2 1 0 2 2 2 0 AAA ATPase domain ABC_tran PF00005.27 CCF32653.1 - 0.052 14.1 0.0 0.052 14.1 0.0 3.9 2 1 0 2 2 2 0 ABC transporter AAA_22 PF13401.6 CCF32653.1 - 0.092 13.0 0.1 0.092 13.0 0.1 3.5 3 0 0 3 3 3 0 AAA domain cobW PF02492.19 CCF32653.1 - 0.29 10.7 0.1 0.29 10.7 0.1 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_15 PF13175.6 CCF32653.1 - 2.8 7.6 40.8 8.6e+02 -0.6 41.1 3.6 1 1 0 1 1 1 0 AAA ATPase domain DUF1754 PF08555.10 CCF32656.1 - 4.9e-10 40.1 22.0 1.2e-08 35.6 22.0 2.3 1 1 0 1 1 1 1 Eukaryotic family of unknown function (DUF1754) AA_permease_2 PF13520.6 CCF32657.1 - 1.6e-60 205.1 42.0 2.1e-60 204.8 42.0 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CCF32657.1 - 4.6e-25 88.2 41.8 1.8e-24 86.2 41.8 1.8 1 1 0 1 1 1 1 Amino acid permease S_4TM PF18159.1 CCF32657.1 - 0.71 9.1 0.0 0.71 9.1 0.0 2.6 3 1 1 4 4 4 0 SMODS-associating 4TM effector domain 2-Hacid_dh_C PF02826.19 CCF32658.1 - 1.3e-52 177.7 0.0 1.5e-52 177.5 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 CCF32658.1 - 7.6e-05 22.9 0.0 0.00013 22.1 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase AlaDh_PNT_C PF01262.21 CCF32658.1 - 0.11 11.8 0.0 0.14 11.4 0.0 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_3 PF01494.19 CCF32661.1 - 3e-75 253.6 0.0 3.9e-75 253.3 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.12 CCF32661.1 - 1.2e-41 142.5 0.0 4.2e-41 140.7 0.0 1.9 2 0 0 2 2 2 1 Phenol hydroxylase, C-terminal dimerisation domain Pyr_redox_2 PF07992.14 CCF32661.1 - 0.00033 20.0 0.0 0.0098 15.2 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCF32661.1 - 0.00036 21.0 0.0 0.0034 17.9 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCF32661.1 - 0.031 14.5 0.0 0.078 13.2 0.0 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 CCF32661.1 - 0.047 12.9 0.0 0.092 12.0 0.0 1.4 1 0 0 1 1 1 0 Thi4 family HI0933_like PF03486.14 CCF32661.1 - 0.053 12.2 0.0 0.099 11.3 0.0 1.4 1 0 0 1 1 1 0 HI0933-like protein XdhC_C PF13478.6 CCF32661.1 - 0.054 14.0 0.0 0.12 12.9 0.0 1.6 1 0 0 1 1 1 0 XdhC Rossmann domain UDPG_MGDP_dh_N PF03721.14 CCF32661.1 - 0.088 12.4 0.0 0.18 11.4 0.0 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain WSC PF01822.19 CCF32663.1 - 2e-17 63.1 6.8 2.7e-17 62.7 6.8 1.2 1 0 0 1 1 1 1 WSC domain IMS PF00817.20 CCF32664.1 - 2.6e-39 134.6 0.0 5.9e-39 133.5 0.0 1.7 1 0 0 1 1 1 1 impB/mucB/samB family REV1_C PF16727.5 CCF32664.1 - 2.9e-26 91.7 2.3 7e-26 90.5 2.3 1.7 1 0 0 1 1 1 1 DNA repair protein REV1 C-terminal domain IMS_C PF11799.8 CCF32664.1 - 2.2e-13 50.9 0.0 4.8e-13 49.8 0.0 1.6 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain UBM PF14377.6 CCF32664.1 - 1.1e-09 37.4 9.1 0.0012 18.2 1.0 3.9 4 0 0 4 4 4 3 Ubiquitin binding region BRCT_2 PF16589.5 CCF32664.1 - 1.5e-06 28.5 0.0 6.6e-06 26.4 0.0 2.2 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain mCpol PF18182.1 CCF32664.1 - 0.002 18.5 0.0 0.0049 17.2 0.0 1.6 1 0 0 1 1 1 1 minimal CRISPR polymerase domain DUF1805 PF08827.11 CCF32664.1 - 0.0069 16.7 0.1 0.12 12.7 0.0 2.8 3 0 0 3 3 3 1 Domain of unknown function (DUF1805) MgtE_N PF03448.17 CCF32664.1 - 0.048 14.3 0.1 4.8 7.8 0.1 3.1 2 0 0 2 2 2 0 MgtE intracellular N domain IMS_HHH PF11798.8 CCF32664.1 - 0.19 12.1 0.2 1.5 9.3 0.0 2.6 2 0 0 2 2 2 0 IMS family HHH motif RED_N PF07808.13 CCF32665.1 - 5.9e-11 42.4 5.9 1.1e-10 41.5 5.9 1.4 1 1 0 1 1 1 1 RED-like protein N-terminal region Lsm_interact PF05391.11 CCF32665.1 - 0.041 13.4 2.4 0.064 12.8 0.5 2.4 2 0 0 2 2 2 0 Lsm interaction motif P66_CC PF16563.5 CCF32665.1 - 0.82 9.3 6.1 1.8 8.3 6.1 1.5 1 0 0 1 1 1 0 Coiled-coil and interaction region of P66A and P66B with MBD2 Hydrolase_4 PF12146.8 CCF32667.1 - 1.9e-12 46.9 0.0 3.6e-12 46.1 0.0 1.4 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CCF32667.1 - 9.6e-10 39.4 0.2 1.3e-09 39.0 0.2 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CCF32667.1 - 5.8e-09 36.0 0.2 9.9e-09 35.2 0.2 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold tRNA-synt_2d PF01409.20 CCF32669.1 - 2.4e-48 164.7 0.2 9e-25 87.6 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) FDX-ACB PF03147.14 CCF32669.1 - 5.4e-25 87.6 0.0 1.1e-24 86.6 0.0 1.6 1 0 0 1 1 1 1 Ferredoxin-fold anticodon binding domain Calcipressin PF04847.12 CCF32671.1 - 4e-52 176.7 0.1 4.9e-52 176.4 0.1 1.1 1 0 0 1 1 1 1 Calcipressin MFS_1 PF07690.16 CCF32674.1 - 2e-30 105.9 34.2 3e-19 69.2 12.4 2.4 2 1 0 2 2 2 2 Major Facilitator Superfamily DUF4187 PF13821.6 CCF32675.1 - 3.2e-23 81.3 3.7 1.1e-22 79.6 3.7 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4187) ddrB-ParB PF18763.1 CCF32675.1 - 0.021 14.9 1.4 0.051 13.7 1.4 1.6 1 0 0 1 1 1 0 ddrB-like ParB superfamily domain PPR_2 PF13041.6 CCF32676.1 - 1.4e-10 41.2 0.1 0.00011 22.3 0.0 5.1 5 0 0 5 5 5 1 PPR repeat family PPR PF01535.20 CCF32676.1 - 1.9e-06 27.7 0.1 0.11 12.8 0.0 4.7 4 0 0 4 4 4 2 PPR repeat PPR_3 PF13812.6 CCF32676.1 - 0.00092 19.2 0.0 0.21 11.7 0.0 3.3 3 0 0 3 3 3 1 Pentatricopeptide repeat domain PPR_1 PF12854.7 CCF32676.1 - 0.0016 18.1 0.1 2.9 7.7 0.0 3.6 4 0 0 4 4 4 2 PPR repeat TPR_19 PF14559.6 CCF32676.1 - 0.13 12.8 0.2 13 6.4 0.0 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat RTC_insert PF05189.13 CCF32677.1 - 7.5e-30 103.5 0.1 1.3e-29 102.7 0.1 1.4 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain RTC PF01137.21 CCF32677.1 - 6.1e-29 100.8 0.3 7.4e-29 100.5 0.3 1.0 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase Peptidase_A21 PF03566.13 CCF32678.1 - 0.2 9.9 0.5 0.2 9.9 0.5 1.0 1 0 0 1 1 1 0 Peptidase family A21 tRNA-synt_2d PF01409.20 CCF32679.1 - 7.6e-86 287.6 0.0 1e-85 287.1 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) PheRS_DBD3 PF18553.1 CCF32679.1 - 1.9e-17 63.3 1.3 4.5e-17 62.1 1.3 1.7 1 0 0 1 1 1 1 PheRS DNA binding domain 3 tRNA_synthFbeta PF17759.1 CCF32679.1 - 1.5e-07 31.1 0.0 0.0034 16.8 0.0 2.9 3 0 0 3 3 3 2 Phenylalanyl tRNA synthetase beta chain CLM domain PheRS_DBD2 PF18554.1 CCF32679.1 - 2.3e-05 24.3 0.5 7.4e-05 22.6 0.5 2.0 1 0 0 1 1 1 1 PheRS DNA binding domain 2 tRNA-synt_2 PF00152.20 CCF32679.1 - 3.6e-05 23.0 0.3 0.0015 17.6 0.0 2.9 3 0 0 3 3 3 1 tRNA synthetases class II (D, K and N) tRNA-synt_2b PF00587.25 CCF32679.1 - 0.0036 17.3 0.0 0.02 14.9 0.0 2.0 1 1 1 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) DUF2960 PF11173.8 CCF32679.1 - 1.7 9.2 3.9 26 5.4 0.0 3.9 4 0 0 4 4 4 0 Protein of unknown function (DUF2960) MFS_1 PF07690.16 CCF32680.1 - 9.3e-33 113.6 60.6 2.8e-24 85.7 38.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Pex14_N PF04695.13 CCF32680.1 - 0.02 15.5 2.1 0.038 14.7 2.1 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF3096 PF11295.8 CCF32680.1 - 0.05 13.3 1.3 0.19 11.4 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3096) DUF2304 PF10066.9 CCF32680.1 - 0.38 11.0 1.9 0.63 10.3 0.4 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2304) DUF4679 PF15728.5 CCF32680.1 - 0.6 9.1 5.0 0.85 8.6 5.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4679) Glyco_hydro_67M PF07488.12 CCF32681.1 - 2.9e-139 463.7 0.0 4e-139 463.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 67 middle domain Glyco_hydro_67C PF07477.12 CCF32681.1 - 1.8e-89 299.1 1.6 2.5e-89 298.6 1.6 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 67 C-terminus Glyco_hydro_67N PF03648.14 CCF32681.1 - 4.6e-26 91.5 0.0 8.1e-26 90.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 67 N-terminus Glyco_hydro_20b PF02838.15 CCF32681.1 - 0.021 15.6 0.1 0.066 14.0 0.1 1.8 1 0 0 1 1 1 0 Glycosyl hydrolase family 20, domain 2 MTS PF05175.14 CCF32682.1 - 0.00058 19.5 0.0 0.0015 18.1 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase small domain LSM PF01423.22 CCF32683.1 - 5.4e-18 64.4 0.1 6.9e-18 64.1 0.1 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 CCF32683.1 - 0.0012 18.9 0.0 0.0017 18.5 0.0 1.3 1 0 0 1 1 1 1 Ataxin 2 SM domain SelK_SelG PF10961.8 CCF32683.1 - 0.043 14.4 5.5 0.066 13.8 5.5 1.3 1 0 0 1 1 1 0 Selenoprotein SelK_SelG Tyrosinase PF00264.20 CCF32684.1 - 6e-47 160.8 2.1 6e-47 160.8 2.1 1.7 2 0 0 2 2 2 1 Common central domain of tyrosinase Tyosinase_C PF18132.1 CCF32684.1 - 3.5e-34 118.1 0.0 5.8e-34 117.4 0.0 1.4 1 0 0 1 1 1 1 Tyosinase C-terminal domain RNA_pol_Rpb2_6 PF00562.28 CCF32685.1 - 1e-112 377.1 0.1 1.3e-112 376.7 0.1 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 CCF32685.1 - 1.1e-33 116.5 0.0 1.6e-33 115.9 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_3 PF04565.16 CCF32685.1 - 9.4e-29 99.4 0.4 2.3e-28 98.2 0.0 1.9 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_2 PF04561.14 CCF32685.1 - 8.8e-26 90.7 0.0 1.4e-25 90.0 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpa2_4 PF06883.12 CCF32685.1 - 9e-24 83.3 0.0 1.9e-23 82.2 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_7 PF04560.20 CCF32685.1 - 6.1e-16 58.6 0.0 1.8e-14 53.9 0.0 2.5 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 7 zinc_ribbon_15 PF17032.5 CCF32685.1 - 0.12 13.1 0.2 0.27 12.0 0.2 1.5 1 0 0 1 1 1 0 zinc-ribbon family DZR PF12773.7 CCF32685.1 - 0.17 12.0 1.3 0.34 11.0 1.3 1.4 1 0 0 1 1 1 0 Double zinc ribbon zf-ANAPC11 PF12861.7 CCF32686.1 - 0.0003 20.8 1.2 0.00041 20.4 1.2 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 CCF32686.1 - 0.047 14.0 0.3 0.08 13.2 0.3 1.4 1 0 0 1 1 1 0 RING-H2 zinc finger domain PNRC PF15365.6 CCF32688.1 - 3e-08 33.2 8.4 3e-08 33.2 8.4 4.6 5 0 0 5 5 5 1 Proline-rich nuclear receptor coactivator motif Tyr-DNA_phospho PF06087.12 CCF32689.1 - 1.8e-89 300.6 0.0 2.2e-89 300.3 0.0 1.1 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase UIM PF02809.20 CCF32689.1 - 9.1e-05 22.1 1.7 9.1e-05 22.1 1.7 2.0 2 0 0 2 2 2 1 Ubiquitin interaction motif PLDc_2 PF13091.6 CCF32689.1 - 0.0029 17.5 0.0 0.015 15.2 0.0 2.0 2 0 0 2 2 2 1 PLD-like domain p450 PF00067.22 CCF32690.1 - 4.4e-18 65.3 0.0 4.6e-18 65.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 AP3D1 PF06375.11 CCF32691.1 - 0.19 11.9 9.1 0.21 11.8 9.1 1.1 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 RNA_pol_Rpb4 PF03874.16 CCF32692.1 - 1.1e-25 90.3 5.3 1.4e-25 90.0 5.3 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb4 CPL PF08144.11 CCF32694.1 - 9.3e-46 155.7 0.4 1.3e-43 148.8 0.0 3.9 4 1 0 4 4 4 1 CPL (NUC119) domain RWD PF05773.22 CCF32695.1 - 6.4e-24 84.5 0.9 1.2e-23 83.6 0.9 1.5 1 0 0 1 1 1 1 RWD domain DFRP_C PF16543.5 CCF32695.1 - 6.7e-06 26.5 7.4 6.7e-06 26.5 7.4 2.1 1 1 1 2 2 2 1 DRG Family Regulatory Proteins, Tma46 MAP7 PF05672.11 CCF32695.1 - 0.001 18.8 10.4 0.0018 18.0 10.4 1.4 1 0 0 1 1 1 1 MAP7 (E-MAP-115) family DUF2852 PF11014.8 CCF32695.1 - 0.062 13.5 3.4 0.092 12.9 3.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2852) Folliculin PF11704.8 CCF32695.1 - 0.28 11.0 1.0 0.4 10.5 1.0 1.2 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport DUF3886 PF13025.6 CCF32695.1 - 3.3 8.0 16.6 8.1 6.7 5.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3886) TPR_19 PF14559.6 CCF32696.1 - 7.5e-05 23.2 0.2 0.11 13.0 0.3 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 CCF32696.1 - 0.00041 20.9 4.1 1.5 9.9 0.1 3.9 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 CCF32696.1 - 0.00089 19.5 0.2 0.18 12.1 0.0 3.2 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 CCF32696.1 - 0.0028 18.3 2.0 3.6 8.3 0.0 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 CCF32696.1 - 0.011 15.5 0.3 10 6.2 0.0 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 CCF32696.1 - 0.035 14.3 0.0 6.5 7.0 0.0 2.5 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.17 CCF32696.1 - 0.55 10.5 5.0 0.68 10.2 0.0 3.6 5 0 0 5 5 5 0 Tetratricopeptide repeat Cyt-b5 PF00173.28 CCF32697.1 - 7.3e-20 70.9 0.3 7.9e-20 70.8 0.3 1.0 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Kelch_2 PF07646.15 CCF32697.1 - 0.1 12.6 0.4 0.14 12.1 0.4 1.3 1 0 0 1 1 1 0 Kelch motif p450 PF00067.22 CCF32698.1 - 9.6e-70 235.6 0.0 1.2e-69 235.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 CorA PF01544.18 CCF32699.1 - 2.8e-08 33.5 0.0 3.7e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein efThoc1 PF11957.8 CCF32700.1 - 1.6e-103 347.0 4.5 1.6e-103 347.0 4.5 1.5 2 0 0 2 2 2 1 THO complex subunit 1 transcription elongation factor Guanylate_kin PF00625.21 CCF32700.1 - 5.8e-29 101.1 0.0 1.2e-28 100.0 0.0 1.6 1 0 0 1 1 1 1 Guanylate kinase MMR_HSR1 PF01926.23 CCF32700.1 - 0.0025 17.9 0.0 0.0075 16.3 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_18 PF13238.6 CCF32700.1 - 0.014 16.0 0.0 0.058 13.9 0.0 2.2 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.6 CCF32700.1 - 0.017 15.3 0.0 2 8.6 0.0 2.6 2 0 0 2 2 2 0 AAA domain Cellulase PF00150.18 CCF32701.1 - 1.6e-15 57.3 0.0 3.9e-15 56.0 0.0 1.6 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) PH PF00169.29 CCF32702.1 - 4.4e-26 91.4 1.3 6.6e-15 55.5 0.1 2.2 2 0 0 2 2 2 2 PH domain PH_11 PF15413.6 CCF32702.1 - 4.5e-09 36.7 5.4 0.00036 20.9 0.7 3.1 2 1 0 2 2 2 2 Pleckstrin homology domain PH_9 PF15410.6 CCF32702.1 - 5.7e-08 33.2 1.5 3.5e-05 24.1 0.5 3.5 2 2 0 2 2 2 1 Pleckstrin homology domain PH_8 PF15409.6 CCF32702.1 - 0.0002 21.6 0.2 0.00042 20.5 0.2 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.6 CCF32702.1 - 0.0095 16.0 1.5 0.024 14.8 0.2 2.3 2 2 1 3 3 3 1 PH domain PH_13 PF16652.5 CCF32702.1 - 0.06 13.2 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain Arc PF03869.14 CCF32704.1 - 0.033 14.0 2.9 3.2 7.7 0.0 3.0 2 0 0 2 2 2 0 Arc-like DNA binding domain Lip_prot_lig_C PF10437.9 CCF32704.1 - 0.14 12.1 5.1 2.8 8.0 0.2 4.0 4 0 0 4 4 4 0 Bacterial lipoate protein ligase C-terminus Gemini_C4 PF01492.17 CCF32704.1 - 0.18 11.7 3.4 0.53 10.2 3.4 1.8 1 0 0 1 1 1 0 Geminivirus C4 protein FliD_C PF07195.12 CCF32704.1 - 1.1 8.6 18.2 0.014 14.8 1.8 3.9 4 1 0 4 4 4 0 Flagellar hook-associated protein 2 C-terminus Metallophos PF00149.28 CCF32705.1 - 6.2e-09 36.6 0.0 7e-09 36.5 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CCF32705.1 - 8.2e-07 29.4 0.0 1e-06 29.0 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Chitin_synth_1 PF01644.17 CCF32707.1 - 3.7e-74 248.1 0.4 5.6e-74 247.5 0.4 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 CCF32707.1 - 1.4e-28 98.6 0.0 2.8e-28 97.7 0.0 1.5 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 CCF32707.1 - 8.1e-22 77.5 4.7 1.9e-17 63.1 0.0 2.6 3 0 0 3 3 3 2 Chitin synthase Glyco_trans_2_3 PF13632.6 CCF32707.1 - 1.3e-05 25.2 7.2 1.3e-05 25.2 7.2 2.6 2 1 0 2 2 2 1 Glycosyl transferase family group 2 RETICULATA-like PF11891.8 CCF32708.1 - 0.068 13.0 0.1 0.94 9.3 0.1 2.0 2 0 0 2 2 2 0 Protein RETICULATA-related Mpp10 PF04006.12 CCF32708.1 - 0.083 11.3 2.9 0.099 11.1 2.9 1.0 1 0 0 1 1 1 0 Mpp10 protein EF-hand_2 PF09068.11 CCF32708.1 - 0.19 11.9 0.0 0.29 11.3 0.0 1.3 1 0 0 1 1 1 0 EF hand IGR PF09597.10 CCF32708.1 - 0.22 11.6 0.8 0.8 9.9 0.8 1.9 1 1 1 2 2 2 0 IGR protein motif DUF4611 PF15387.6 CCF32708.1 - 7.1 6.9 7.7 1.8 8.8 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) WCCH PF03716.14 CCF32710.1 - 0.077 12.7 3.0 0.13 11.9 3.0 1.3 1 0 0 1 1 1 0 WCCH motif p450 PF00067.22 CCF32711.1 - 9.9e-66 222.4 0.0 1.3e-65 222.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF2478 PF10649.9 CCF32711.1 - 0.1 12.2 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2478) AA_permease PF00324.21 CCF32712.1 - 6.9e-119 397.6 41.6 7.9e-119 397.4 41.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CCF32712.1 - 1.6e-35 122.8 49.2 2.3e-35 122.2 49.2 1.2 1 0 0 1 1 1 1 Amino acid permease DUF2101 PF09874.9 CCF32712.1 - 0.029 14.1 0.1 0.078 12.7 0.1 1.6 1 0 0 1 1 1 0 Predicted membrane protein (DUF2101) Med1 PF10744.9 CCF32713.1 - 1.3e-126 423.0 0.0 1.6e-126 422.7 0.0 1.1 1 0 0 1 1 1 1 Mediator of RNA polymerase II transcription subunit 1 Ribosomal_S3Ae PF01015.18 CCF32714.1 - 8.3e-16 58.2 0.2 1.1e-15 57.8 0.2 1.2 1 0 0 1 1 1 1 Ribosomal S3Ae family Abhydrolase_1 PF00561.20 CCF32715.1 - 1.5e-15 57.6 0.0 8.6e-14 51.8 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCF32715.1 - 0.00011 22.9 0.0 0.00013 22.7 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCF32715.1 - 0.00013 21.3 0.0 0.00025 20.4 0.0 1.5 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Esterase PF00756.20 CCF32715.1 - 0.00033 20.4 0.0 0.00041 20.1 0.0 1.2 1 0 0 1 1 1 1 Putative esterase PGAP1 PF07819.13 CCF32715.1 - 0.018 14.8 0.0 0.024 14.3 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein Ndr PF03096.14 CCF32715.1 - 0.057 12.1 0.0 0.083 11.6 0.0 1.2 1 0 0 1 1 1 0 Ndr family Thioesterase PF00975.20 CCF32715.1 - 0.064 13.4 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 Thioesterase domain Chlorophyllase2 PF12740.7 CCF32715.1 - 0.12 11.2 0.0 0.18 10.7 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme Bromodomain PF00439.25 CCF32720.1 - 2.2e-05 24.4 0.0 8.1e-05 22.6 0.0 1.8 1 1 0 1 1 1 1 Bromodomain Folliculin PF11704.8 CCF32720.1 - 0.25 11.2 0.9 14 5.5 0.6 3.0 3 0 0 3 3 3 0 Vesicle coat protein involved in Golgi to plasma membrane transport eIF-3_zeta PF05091.12 CCF32720.1 - 0.89 8.5 6.6 1.4 7.8 6.6 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Presenilin PF01080.17 CCF32720.1 - 1 8.1 7.4 2.9 6.5 7.4 1.8 1 0 0 1 1 1 0 Presenilin SpoIIP PF07454.11 CCF32720.1 - 3.1 7.2 6.4 5.7 6.3 6.4 1.3 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) AT_hook PF02178.19 CCF32720.1 - 3.1 8.0 8.4 13 6.0 6.7 3.2 2 0 0 2 2 2 0 AT hook motif DUF4770 PF15994.5 CCF32720.1 - 4.7 7.4 14.6 18 5.5 14.6 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) MCU PF04678.13 CCF32720.1 - 4.9 7.2 9.5 0.98 9.5 0.1 2.3 2 0 0 2 2 2 0 Mitochondrial calcium uniporter DASH_Dad1 PF08649.10 CCF32722.1 - 8.1e-27 93.2 2.9 1e-26 92.9 2.9 1.1 1 0 0 1 1 1 1 DASH complex subunit Dad1 DASH_Dad4 PF08650.10 CCF32722.1 - 0.021 14.8 0.6 0.029 14.3 0.6 1.1 1 0 0 1 1 1 0 DASH complex subunit Dad4 CK2S PF15011.6 CCF32722.1 - 0.069 13.0 0.1 0.077 12.9 0.1 1.2 1 0 0 1 1 1 0 Casein Kinase 2 substrate ATP-synt_E_2 PF08112.11 CCF32722.1 - 0.16 12.3 0.1 0.25 11.6 0.1 1.3 1 0 0 1 1 1 0 ATP synthase epsilon subunit Diacid_rec PF05651.13 CCF32723.1 - 0.072 12.8 0.0 0.18 11.5 0.0 1.6 1 0 0 1 1 1 0 Putative sugar diacid recognition YjbH PF06082.11 CCF32723.1 - 0.28 9.9 0.6 0.37 9.6 0.6 1.1 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH GvpL_GvpF PF06386.11 CCF32723.1 - 0.31 11.0 3.5 1.4 8.8 0.1 2.2 2 0 0 2 2 2 0 Gas vesicle synthesis protein GvpL/GvpF HAP1_N PF04849.13 CCF32723.1 - 0.55 9.4 6.5 1.1 8.4 6.5 1.6 1 1 0 1 1 1 0 HAP1 N-terminal conserved region DASH_Dad2 PF08654.10 CCF32723.1 - 2.9 8.4 6.2 6.5 7.2 0.4 3.0 3 0 0 3 3 3 0 DASH complex subunit Dad2 MRPL52 PF18699.1 CCF32723.1 - 3 8.1 8.1 1.5 9.1 1.2 2.9 2 1 1 3 3 3 0 Mitoribosomal protein mL52 DUF3593 PF12159.8 CCF32724.1 - 2 8.5 4.4 0.49 10.5 0.5 2.0 2 1 1 3 3 3 0 Protein of unknown function (DUF3593) RNA_pol_Rpb5_C PF01191.19 CCF32725.1 - 7.9e-34 115.4 0.2 1.1e-33 114.9 0.2 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain SH3_2 PF07653.17 CCF32725.1 - 0.18 11.5 0.0 0.24 11.1 0.0 1.4 1 1 0 1 1 1 0 Variant SH3 domain Amino_oxidase PF01593.24 CCF32726.1 - 4e-24 85.7 0.2 3e-22 79.6 0.1 2.3 2 1 0 2 2 2 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CCF32726.1 - 1.1e-13 51.2 0.1 3e-13 49.8 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CCF32726.1 - 2e-11 44.1 0.7 3.4e-10 40.1 0.7 2.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCF32726.1 - 6.3e-09 35.5 0.1 2.6e-05 23.6 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CCF32726.1 - 3.6e-08 32.9 2.0 2.4e-05 23.6 1.6 2.2 2 0 0 2 2 2 2 FAD binding domain HI0933_like PF03486.14 CCF32726.1 - 1.4e-07 30.6 0.3 0.0017 17.1 0.9 2.1 2 0 0 2 2 2 2 HI0933-like protein FAD_oxidored PF12831.7 CCF32726.1 - 2e-05 24.2 0.0 0.0004 19.9 0.0 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 CCF32726.1 - 0.0005 19.4 0.1 0.00087 18.6 0.1 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCF32726.1 - 0.0028 18.2 2.2 0.16 12.6 0.8 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 CCF32726.1 - 0.0054 16.0 0.6 0.0096 15.2 0.6 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_9 PF13454.6 CCF32726.1 - 0.02 14.9 2.9 0.15 12.0 0.1 2.5 3 0 0 3 3 2 0 FAD-NAD(P)-binding Lycopene_cycl PF05834.12 CCF32726.1 - 0.021 13.9 0.6 0.021 13.9 0.6 2.0 3 0 0 3 3 3 0 Lycopene cyclase protein Thi4 PF01946.17 CCF32726.1 - 0.029 13.6 0.1 0.05 12.8 0.1 1.3 1 0 0 1 1 1 0 Thi4 family GMC_oxred_N PF00732.19 CCF32726.1 - 0.05 13.0 0.3 2.1 7.6 0.0 2.2 2 0 0 2 2 2 0 GMC oxidoreductase ApbA PF02558.16 CCF32726.1 - 0.057 13.1 0.6 0.11 12.1 0.6 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Trp_halogenase PF04820.14 CCF32726.1 - 0.065 12.1 0.4 6 5.6 0.0 2.4 2 0 0 2 2 2 0 Tryptophan halogenase XdhC_C PF13478.6 CCF32726.1 - 0.099 13.1 0.1 1.1 9.8 0.0 2.3 2 0 0 2 2 2 0 XdhC Rossmann domain adh_short PF00106.25 CCF32726.1 - 0.15 11.5 0.9 0.26 10.7 0.9 1.3 1 0 0 1 1 1 0 short chain dehydrogenase GIDA PF01134.22 CCF32726.1 - 0.15 11.1 3.0 0.21 10.6 1.9 1.7 2 0 0 2 2 2 0 Glucose inhibited division protein A 3HCDH_N PF02737.18 CCF32726.1 - 0.22 11.4 0.5 0.37 10.6 0.5 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DASH_Hsk3 PF08227.11 CCF32727.1 - 3.8e-21 75.2 2.6 5.3e-21 74.7 2.6 1.2 1 0 0 1 1 1 1 DASH complex subunit Hsk3 like BBS2_C PF14782.6 CCF32727.1 - 0.012 14.4 0.0 0.013 14.3 0.0 1.0 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, C-terminal ApbA PF02558.16 CCF32729.1 - 6.4e-25 87.6 0.0 9.5e-25 87.0 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ApbA_C PF08546.11 CCF32729.1 - 1.8e-23 83.1 0.0 2.7e-23 82.5 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal AGH PF17558.2 CCF32729.1 - 0.19 11.9 0.2 0.4 10.9 0.2 1.4 1 0 0 1 1 1 0 Androgenic gland hormone SPRY PF00622.28 CCF32730.1 - 4.6e-27 94.5 0.2 8.2e-27 93.7 0.2 1.4 1 0 0 1 1 1 1 SPRY domain CLTH PF10607.9 CCF32730.1 - 1.3e-25 90.0 0.2 2.7e-25 89.0 0.2 1.5 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 CCF32730.1 - 4.8e-06 26.3 0.4 1.1e-05 25.2 0.1 1.8 2 0 0 2 2 2 1 LisH INO80_Ies4 PF08193.11 CCF32732.1 - 3.4e-83 279.4 17.4 4.1e-83 279.1 17.4 1.2 1 0 0 1 1 1 1 INO80 complex subunit Ies4 ketoacyl-synt PF00109.26 CCF32733.1 - 5.6e-69 232.5 0.0 2.9e-68 230.2 0.0 2.0 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 CCF32733.1 - 4.3e-41 141.5 0.0 6.5e-41 140.9 0.0 1.2 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 CCF32733.1 - 1.1e-40 138.4 0.1 2.3e-40 137.3 0.1 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PS-DH PF14765.6 CCF32733.1 - 3.3e-39 134.9 0.1 1.6e-38 132.7 0.0 1.9 2 0 0 2 2 2 1 Polyketide synthase dehydratase KAsynt_C_assoc PF16197.5 CCF32733.1 - 2.9e-13 50.2 0.1 6.1e-09 36.3 0.1 2.6 2 0 0 2 2 2 2 Ketoacyl-synthetase C-terminal extension Thiolase_N PF00108.23 CCF32733.1 - 4.4e-06 26.3 0.0 9.7e-06 25.1 0.0 1.5 1 0 0 1 1 1 1 Thiolase, N-terminal domain ACP_syn_III PF08545.10 CCF32733.1 - 0.028 14.3 0.2 0.081 12.8 0.2 1.8 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III p450 PF00067.22 CCF32734.1 - 7.5e-51 173.3 0.0 1.1e-50 172.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Med9 PF07544.13 CCF32735.1 - 0.088 12.9 0.6 6.4 6.9 0.0 2.6 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Actin PF00022.19 CCF32736.1 - 3.2e-133 444.3 0.0 1.2e-132 442.4 0.0 1.7 1 1 0 1 1 1 1 Actin RF-1 PF00472.20 CCF32737.1 - 2.7e-24 85.4 4.7 3.8e-24 84.9 4.7 1.2 1 0 0 1 1 1 1 RF-1 domain SPT_ssu-like PF11779.8 CCF32738.1 - 5.2e-21 74.0 5.6 7.2e-21 73.6 5.6 1.2 1 0 0 1 1 1 1 Small subunit of serine palmitoyltransferase-like Cytochrome-c551 PF10643.9 CCF32738.1 - 0.053 13.1 0.9 0.059 12.9 0.9 1.2 1 0 0 1 1 1 0 Photosystem P840 reaction-centre cytochrome c-551 WD40 PF00400.32 CCF32739.1 - 2.2e-33 113.7 20.7 4.3e-05 24.2 0.0 11.5 13 0 0 13 13 13 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF32739.1 - 5e-08 33.1 0.2 1.4 9.3 0.1 7.2 5 3 3 8 8 8 2 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 CCF32739.1 - 0.023 14.7 0.0 4.5 7.4 0.0 4.2 5 0 0 5 5 5 0 Ciliary BBSome complex subunit 2, middle region Ge1_WD40 PF16529.5 CCF32739.1 - 0.052 12.5 0.0 17 4.2 0.0 3.8 4 1 0 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF4596 PF15363.6 CCF32739.1 - 0.085 13.1 0.0 0.21 11.9 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4596) Urm1 PF09138.11 CCF32740.1 - 2.2e-33 114.5 0.0 2.6e-33 114.3 0.0 1.0 1 0 0 1 1 1 1 Urm1 (Ubiquitin related modifier) ThiS PF02597.20 CCF32740.1 - 0.00095 19.8 0.1 0.0018 18.9 0.0 1.5 2 0 0 2 2 2 1 ThiS family NAD_kinase PF01513.21 CCF32743.1 - 1.8e-81 273.5 0.0 2.7e-81 273.0 0.0 1.2 1 0 0 1 1 1 1 ATP-NAD kinase Homeodomain PF00046.29 CCF32745.1 - 1.9e-13 50.0 1.3 2.9e-13 49.4 0.5 1.7 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 CCF32745.1 - 0.018 14.9 0.1 0.04 13.8 0.1 1.6 1 0 0 1 1 1 0 Homeobox KN domain Pkinase PF00069.25 CCF32747.1 - 5.5e-10 39.1 0.0 0.0048 16.3 0.0 3.5 4 0 0 4 4 4 3 Protein kinase domain Pkinase_Tyr PF07714.17 CCF32747.1 - 6.6e-07 28.9 0.0 0.05 12.9 0.0 3.7 3 1 0 3 3 3 3 Protein tyrosine kinase Aldo_ket_red PF00248.21 CCF32748.1 - 8.8e-41 140.0 0.0 1.1e-40 139.7 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family LRR_4 PF12799.7 CCF32749.1 - 3.1e-35 119.6 25.0 8.4e-08 32.4 2.1 6.3 4 1 0 6 6 6 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCF32749.1 - 4.1e-23 80.9 24.5 1.2e-06 28.2 2.8 5.4 2 2 1 4 4 4 4 Leucine rich repeat LRR_9 PF14580.6 CCF32749.1 - 4.5e-14 52.3 11.8 1.4e-05 24.7 3.8 4.1 1 1 3 4 4 4 4 Leucine-rich repeat LRR_6 PF13516.6 CCF32749.1 - 3.7e-06 26.6 18.2 0.35 11.0 0.3 8.1 10 0 0 10 10 10 3 Leucine Rich repeat LRR_1 PF00560.33 CCF32749.1 - 1.8e-05 24.7 13.6 16 6.5 0.3 8.8 8 3 1 9 9 9 1 Leucine Rich Repeat Abhydrolase_6 PF12697.7 CCF32750.1 - 1.2e-05 26.1 2.3 1.2e-05 26.1 2.3 2.2 2 1 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CCF32750.1 - 8.9e-05 22.2 0.0 0.0016 18.1 0.0 2.1 1 1 1 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 CCF32750.1 - 0.0025 17.7 0.0 0.006 16.5 0.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CCF32750.1 - 0.0067 15.7 0.0 0.047 13.0 0.0 2.0 1 1 1 2 2 2 1 Serine aminopeptidase, S33 BTB PF00651.31 CCF32751.1 - 1.3e-06 28.7 0.1 5.3e-06 26.6 0.0 2.0 3 0 0 3 3 3 1 BTB/POZ domain PCI PF01399.27 CCF32752.1 - 3.3e-06 27.5 0.0 5.6e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 PCI domain Thiolase_N PF00108.23 CCF32753.1 - 6.2e-77 258.5 2.6 8.9e-77 258.0 2.6 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 CCF32753.1 - 3.5e-40 136.5 0.2 6.9e-40 135.5 0.2 1.5 1 0 0 1 1 1 1 Thiolase, C-terminal domain ACP_syn_III_C PF08541.10 CCF32753.1 - 0.012 15.8 0.0 0.056 13.6 0.0 2.2 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ketoacyl-synt PF00109.26 CCF32753.1 - 0.13 11.9 2.9 0.11 12.1 0.3 2.1 2 1 1 3 3 3 0 Beta-ketoacyl synthase, N-terminal domain NMO PF03060.15 CCF32754.1 - 8.5e-54 183.1 0.2 6.5e-53 180.2 0.2 1.9 1 1 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 CCF32754.1 - 6.8e-14 51.6 0.0 8.8e-12 44.7 0.0 2.1 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 CCF32754.1 - 0.00071 18.7 0.2 0.0013 17.8 0.2 1.4 1 0 0 1 1 1 1 FMN-dependent dehydrogenase GIDA PF01134.22 CCF32756.1 - 9.4e-154 512.2 0.0 1.2e-153 511.8 0.0 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A GIDA_assoc PF13932.6 CCF32756.1 - 8e-66 222.2 0.1 1.5e-65 221.3 0.1 1.4 1 0 0 1 1 1 1 GidA associated domain FAD_oxidored PF12831.7 CCF32756.1 - 0.014 14.8 0.4 0.025 14.0 0.4 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCF32756.1 - 0.017 14.4 0.7 0.31 10.2 0.5 2.3 1 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Sec1 PF00995.23 CCF32757.1 - 1.1e-135 454.1 0.0 1.3e-135 453.9 0.0 1.0 1 0 0 1 1 1 1 Sec1 family DUF1204 PF06721.11 CCF32757.1 - 0.052 13.0 0.1 0.28 10.6 0.0 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF1204) MMM1 PF10296.9 CCF32758.1 - 8.1e-142 472.1 0.1 2.6e-140 467.2 0.1 2.0 1 1 0 1 1 1 1 Maintenance of mitochondrial morphology protein 1 DUF913 PF06025.12 CCF32759.1 - 9.3e-134 446.0 0.0 9.3e-134 446.0 0.0 5.8 5 1 0 5 5 5 2 Domain of Unknown Function (DUF913) UBM PF14377.6 CCF32759.1 - 5.5e-25 86.0 25.3 1.5e-08 33.8 0.2 4.6 4 0 0 4 4 4 3 Ubiquitin binding region APG6 PF04111.12 CCF32761.1 - 6.6e-62 208.6 0.0 1.1e-61 207.9 0.0 1.3 1 0 0 1 1 1 1 Apg6 BARA domain APG6_N PF17675.1 CCF32761.1 - 2.5e-37 128.4 13.8 3.7e-37 127.8 13.8 1.3 1 0 0 1 1 1 1 Apg6 coiled-coil region zf-C4H2 PF10146.9 CCF32761.1 - 0.0098 16.2 0.1 0.0098 16.2 0.1 2.0 2 0 0 2 2 2 1 Zinc finger-containing protein Rpr2 PF04032.16 CCF32761.1 - 0.066 13.5 0.1 0.33 11.3 0.0 2.2 2 0 0 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain KASH_CCD PF14662.6 CCF32761.1 - 0.19 11.5 10.1 0.32 10.8 10.1 1.2 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH UPF0242 PF06785.11 CCF32761.1 - 0.5 10.4 10.3 0.86 9.7 10.3 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus V_ATPase_I PF01496.19 CCF32761.1 - 2.1 6.2 3.2 2.8 5.7 3.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Scm3 PF10384.9 CCF32763.1 - 3.7e-20 71.4 0.1 3.7e-20 71.4 0.1 2.4 3 0 0 3 3 3 1 Centromere protein Scm3 Dynamin_N PF00350.23 CCF32765.1 - 6.3e-05 23.1 0.0 0.47 10.5 0.0 2.3 2 0 0 2 2 2 2 Dynamin family MMR_HSR1 PF01926.23 CCF32765.1 - 0.0011 19.0 0.0 0.0045 17.1 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_24 PF13479.6 CCF32765.1 - 0.008 15.9 0.0 0.011 15.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain ATP_bind_1 PF03029.17 CCF32765.1 - 0.031 14.1 0.0 0.14 11.9 0.0 2.0 2 1 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_22 PF13401.6 CCF32765.1 - 0.085 13.1 0.0 0.3 11.3 0.0 2.0 1 1 0 1 1 1 0 AAA domain Syntaxin_2 PF14523.6 CCF32765.1 - 0.13 12.7 0.1 0.2 12.1 0.1 1.2 1 0 0 1 1 1 0 Syntaxin-like protein Septin PF00735.18 CCF32765.1 - 0.18 11.1 0.0 0.41 9.9 0.0 1.6 1 1 0 1 1 1 0 Septin Ank_2 PF12796.7 CCF32766.1 - 5e-07 30.2 0.0 0.16 12.6 0.0 4.1 4 0 0 4 4 4 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CCF32766.1 - 1.5e-05 25.4 0.4 11 6.7 0.0 5.3 6 0 0 6 6 6 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCF32766.1 - 3.9e-05 23.7 3.0 9.9 7.1 0.0 6.1 7 0 0 7 7 7 1 Ankyrin repeat Ank_5 PF13857.6 CCF32766.1 - 0.019 15.3 0.6 48 4.4 0.0 4.8 5 1 0 5 5 5 0 Ankyrin repeats (many copies) DUF3340 PF11818.8 CCF32767.1 - 0.023 14.9 4.6 0.045 13.9 4.6 1.4 1 0 0 1 1 1 0 C-terminal domain of tail specific protease (DUF3340) NPCC PF08058.11 CCF32768.1 - 1.1 9.3 4.5 3.6 7.7 4.5 1.7 1 1 0 1 1 1 0 Nuclear pore complex component AMPK1_CBM PF16561.5 CCF32769.1 - 1.8e-06 28.0 0.1 2.9e-06 27.4 0.1 1.3 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase Pkinase PF00069.25 CCF32771.1 - 1.4e-63 214.7 0.0 1.7e-63 214.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF32771.1 - 1.7e-30 106.2 0.0 2.2e-30 105.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 CCF32771.1 - 0.00076 18.5 0.0 0.0013 17.8 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 CCF32771.1 - 0.0066 15.8 0.1 0.031 13.6 0.0 1.9 2 1 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 CCF32771.1 - 0.018 13.8 0.0 0.03 13.1 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Asparaginase PF00710.20 CCF32772.1 - 3.7e-57 193.0 0.0 6e-57 192.3 0.0 1.3 1 0 0 1 1 1 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 CCF32772.1 - 1.1e-26 93.3 0.0 2.1e-26 92.4 0.0 1.5 1 0 0 1 1 1 1 Glutaminase/Asparaginase C-terminal domain Ank_2 PF12796.7 CCF32772.1 - 1.9e-14 54.0 0.1 1.2e-08 35.4 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 CCF32772.1 - 1.1e-08 35.1 0.0 0.0079 16.6 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 CCF32772.1 - 5.8e-08 33.1 0.0 1.1e-05 25.9 0.0 2.6 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 CCF32772.1 - 9.1e-06 25.9 0.2 0.00019 21.7 0.3 2.5 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCF32772.1 - 0.00048 20.4 0.0 0.67 10.7 0.0 3.7 3 0 0 3 3 3 1 Ankyrin repeat GRIM-19 PF06212.12 CCF32773.1 - 3e-24 85.4 0.1 1.2e-23 83.5 0.1 1.7 1 1 0 1 1 1 1 GRIM-19 protein Bac_rhamnosid_C PF17390.2 CCF32774.1 - 6.7e-12 45.0 0.1 3.6e-11 42.7 0.0 2.1 2 0 0 2 2 2 1 Bacterial alpha-L-rhamnosidase C-terminal domain Bac_rhamnosid6H PF17389.2 CCF32774.1 - 1.6e-10 40.8 0.0 3.5e-09 36.4 0.0 2.1 2 0 0 2 2 2 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain DUF1080 PF06439.11 CCF32774.1 - 0.0084 16.2 0.0 0.15 12.2 0.0 2.6 2 1 0 2 2 2 1 Domain of Unknown Function (DUF1080) Cnd1 PF12717.7 CCF32775.1 - 7e-50 169.2 4.5 2.9e-45 154.2 0.4 2.9 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 CCF32775.1 - 7.1e-10 39.1 1.1 0.00045 20.5 0.1 4.7 3 1 1 4 4 4 2 HEAT repeats HEAT PF02985.22 CCF32775.1 - 2e-09 36.9 8.3 0.028 14.6 0.0 6.4 6 0 0 6 6 6 2 HEAT repeat Adaptin_N PF01602.20 CCF32775.1 - 5.3e-06 25.3 2.5 0.002 16.8 0.4 3.2 3 0 0 3 3 3 2 Adaptin N terminal region HEAT_EZ PF13513.6 CCF32775.1 - 1.1e-05 25.8 6.0 0.031 14.8 0.2 5.0 4 1 0 4 4 4 1 HEAT-like repeat RTP1_C1 PF10363.9 CCF32775.1 - 3.1e-05 24.1 0.1 0.045 13.9 0.0 3.6 2 1 1 3 3 3 1 Required for nuclear transport of RNA pol II C-terminus 1 Cnd3 PF12719.7 CCF32775.1 - 0.00088 18.6 4.9 0.005 16.1 2.4 2.8 2 1 0 2 2 2 1 Nuclear condensing complex subunits, C-term domain Ssl1 PF04056.14 CCF32775.1 - 0.044 13.6 0.0 0.45 10.3 0.0 2.5 2 0 0 2 2 2 0 Ssl1-like DUF5445 PF17520.2 CCF32775.1 - 0.13 12.1 0.1 4.1 7.3 0.0 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5445) CPSF_A PF03178.15 CCF32776.1 - 5.3e-82 275.7 0.0 7.3e-82 275.3 0.0 1.2 1 0 0 1 1 1 1 CPSF A subunit region Pal1 PF08316.11 CCF32777.1 - 5.2e-09 37.0 0.2 1.3e-08 35.7 0.0 1.7 2 0 0 2 2 2 1 Pal1 cell morphology protein HVSL PF09749.9 CCF32778.1 - 8e-78 261.2 0.0 9.4e-78 261.0 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised conserved protein MFS_1 PF07690.16 CCF32779.1 - 1.3e-14 53.9 18.4 1.7e-14 53.5 18.4 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily TauD PF02668.16 CCF32780.1 - 2.3e-45 155.5 0.1 3.3e-45 155.0 0.1 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family UL16 PF17622.2 CCF32780.1 - 0.021 14.5 0.0 0.038 13.6 0.0 1.3 1 0 0 1 1 1 0 Viral unique long protein 16 Ax_dynein_light PF10211.9 CCF32780.1 - 0.042 13.8 0.0 0.082 12.9 0.0 1.4 1 0 0 1 1 1 0 Axonemal dynein light chain MFS_1 PF07690.16 CCF32782.1 - 1.8e-30 106.1 30.1 1.3e-29 103.3 28.6 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily HET PF06985.11 CCF32783.1 - 2.2e-26 92.9 0.0 3.8e-26 92.2 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) DLH PF01738.18 CCF32783.1 - 0.047 13.2 0.0 0.13 11.8 0.0 1.7 1 1 1 2 2 2 0 Dienelactone hydrolase family PP2C PF00481.21 CCF32784.1 - 3.4e-43 148.1 0.0 5.8e-43 147.4 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 CCF32784.1 - 0.022 14.7 0.1 0.78 9.6 0.0 2.5 3 0 0 3 3 3 0 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 CCF32784.1 - 0.038 13.6 0.2 0.076 12.6 0.2 1.4 1 0 0 1 1 1 0 Protein phosphatase 2C Pkinase PF00069.25 CCF32785.1 - 5.4e-75 252.1 0.0 7.5e-75 251.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF32785.1 - 8.4e-31 107.2 0.0 3.8e-22 78.8 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 CCF32785.1 - 1.5e-06 27.8 0.1 0.9 8.8 0.0 3.1 3 0 0 3 3 3 3 Kinase-like Pkinase_fungal PF17667.1 CCF32785.1 - 0.013 14.3 0.0 0.022 13.6 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Kdo PF06293.14 CCF32785.1 - 0.028 13.8 0.0 0.045 13.1 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CCF32785.1 - 0.073 13.0 0.0 1.8 8.4 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family SMC_N PF02463.19 CCF32787.1 - 8.2e-73 244.5 20.8 5.4e-72 241.8 20.8 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 CCF32787.1 - 2.5e-24 85.9 0.1 1.2e-23 83.6 0.0 2.4 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 CCF32787.1 - 3.4e-12 46.8 1.9 5.2e-05 23.2 0.0 3.3 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system Tektin PF03148.14 CCF32787.1 - 0.00041 19.2 16.9 0.00041 19.2 16.9 6.7 2 2 5 7 7 7 1 Tektin family AAA_29 PF13555.6 CCF32787.1 - 0.00052 19.7 0.0 0.001 18.8 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain Tropomyosin_1 PF12718.7 CCF32787.1 - 0.0046 17.1 16.0 0.0046 17.1 16.0 8.5 3 2 6 9 9 9 2 Tropomyosin like ParE_toxin PF05016.15 CCF32787.1 - 0.81 10.3 6.4 2 9.1 0.6 3.6 2 0 0 2 2 2 0 ParE toxin of type II toxin-antitoxin system, parDE ABC_tran PF00005.27 CCF32787.1 - 1.1 9.7 0.0 1.1 9.7 0.0 7.1 5 3 0 5 5 5 0 ABC transporter Spc7 PF08317.11 CCF32787.1 - 1.2 8.0 130.7 0.01 14.8 29.2 7.8 2 2 4 7 7 7 0 Spc7 kinetochore protein ELYS PF13934.6 CCF32788.1 - 6e-40 137.6 0.3 7.5e-40 137.3 0.3 1.1 1 0 0 1 1 1 1 Nuclear pore complex assembly PAN_4 PF14295.6 CCF32789.1 - 0.095 12.6 5.1 0.38 10.7 5.1 1.9 1 1 0 1 1 1 0 PAN domain Glyco_transf_22 PF03901.17 CCF32790.1 - 4.3e-60 204.1 22.6 5.4e-60 203.8 22.6 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family PMT_2 PF13231.6 CCF32790.1 - 0.012 15.9 6.7 0.012 15.9 6.7 2.4 2 0 0 2 2 2 0 Dolichyl-phosphate-mannose-protein mannosyltransferase Skp1 PF01466.19 CCF32791.1 - 1.3e-29 102.1 0.4 3.4e-29 100.7 0.4 1.8 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 CCF32791.1 - 1.6e-21 76.2 0.7 3.7e-21 75.1 0.4 1.8 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain SecE PF00584.20 CCF32793.1 - 1.5e-14 53.6 0.0 1.7e-14 53.4 0.0 1.1 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex WD40 PF00400.32 CCF32794.1 - 5.7e-22 77.6 17.1 0.00017 22.3 0.6 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF32794.1 - 0.00068 19.9 0.0 0.16 12.3 0.0 3.3 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 CCF32794.1 - 0.0011 17.6 2.7 0.23 9.9 0.0 3.7 3 1 1 4 4 4 2 Cytochrome D1 heme domain PD40 PF07676.12 CCF32794.1 - 0.025 14.5 0.3 0.15 12.0 0.0 2.5 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat DUF4641 PF15483.6 CCF32794.1 - 0.15 11.2 0.1 0.32 10.1 0.1 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4641) Trypan_PARP PF05887.11 CCF32794.1 - 0.39 10.7 3.6 0.84 9.6 3.6 1.5 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) DUF287 PF03384.14 CCF32794.1 - 1.8 9.0 5.6 1.1 9.7 0.1 3.1 3 0 0 3 3 3 0 Drosophila protein of unknown function, DUF287 BUD22 PF09073.10 CCF32794.1 - 3.2 7.0 8.1 5 6.4 8.1 1.3 1 0 0 1 1 1 0 BUD22 UPF0016 PF01169.19 CCF32795.1 - 8.4e-41 138.2 25.0 2.1e-20 72.8 7.2 2.2 2 0 0 2 2 2 2 Uncharacterized protein family UPF0016 UPF0370 PF13980.6 CCF32795.1 - 0.27 11.3 0.1 0.27 11.3 0.1 2.4 4 0 0 4 4 4 0 Uncharacterised protein family (UPF0370) HET PF06985.11 CCF32796.1 - 1.4e-22 80.7 0.0 3.3e-22 79.4 0.0 1.7 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Peptidase_C2 PF00648.21 CCF32797.1 - 2.7e-58 197.3 0.2 5.9e-57 193.0 0.2 2.2 1 1 0 1 1 1 1 Calpain family cysteine protease COesterase PF00135.28 CCF32799.1 - 4e-66 223.9 0.0 4.9e-66 223.6 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CCF32799.1 - 1.7e-09 37.8 0.3 1.7e-06 28.0 0.0 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CCF32799.1 - 0.00062 19.3 0.1 0.0011 18.5 0.1 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family EKR PF10371.9 CCF32799.1 - 0.17 11.7 0.0 0.37 10.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function NAD_binding_10 PF13460.6 CCF32800.1 - 2.4e-16 60.1 0.0 3.9e-16 59.5 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 CCF32800.1 - 4e-15 56.0 0.0 6.2e-15 55.4 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family Sacchrp_dh_NADP PF03435.18 CCF32800.1 - 2.9e-06 27.6 0.0 5e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 CCF32800.1 - 2.4e-05 24.4 0.0 4.2e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_2 PF03446.15 CCF32800.1 - 0.015 15.4 0.0 0.027 14.7 0.0 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Epimerase PF01370.21 CCF32800.1 - 0.057 12.9 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family 3HCDH_N PF02737.18 CCF32800.1 - 0.14 12.0 0.1 0.25 11.2 0.1 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Fungal_trans PF04082.18 CCF32801.1 - 2e-08 33.6 0.0 3.2e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Git3 PF11710.8 CCF32802.1 - 7.4e-23 81.4 7.1 1.1e-22 80.8 7.1 1.2 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 7tm_1 PF00001.21 CCF32802.1 - 8.3e-13 48.3 0.0 1.1e-12 47.8 0.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Dicty_CAR PF05462.11 CCF32802.1 - 8.7e-09 34.9 8.5 5.8e-07 28.9 6.5 2.1 2 0 0 2 2 2 2 Slime mold cyclic AMP receptor GPR_Gpa2_C PF11970.8 CCF32802.1 - 0.00025 21.0 0.5 0.0022 18.0 0.0 2.4 2 0 0 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 C-term Cu_amine_oxid PF01179.20 CCF32803.1 - 5.1e-72 243.0 2.4 6.2e-72 242.7 2.4 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain DUF1965 PF09248.10 CCF32803.1 - 2.1e-11 43.4 0.8 7.6e-11 41.6 0.1 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF1965) ADH_zinc_N PF00107.26 CCF32804.1 - 3.6e-16 59.3 0.0 5.5e-16 58.7 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCF32804.1 - 1.1e-13 52.4 0.0 2.4e-13 51.3 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCF32804.1 - 3.7e-07 30.0 0.1 1.6e-06 27.9 0.1 1.9 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain NmrA PF05368.13 CCF32805.1 - 9.5e-29 100.6 0.0 1.2e-28 100.3 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CCF32805.1 - 6.4e-15 55.5 0.0 1.1e-14 54.8 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 CCF32805.1 - 0.00014 22.1 0.4 0.00041 20.6 0.1 1.8 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain DapB_N PF01113.20 CCF32805.1 - 0.00023 21.3 0.2 0.00039 20.5 0.2 1.3 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Epimerase PF01370.21 CCF32805.1 - 0.00089 18.8 0.0 0.12 11.8 0.1 3.0 1 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 CCF32805.1 - 0.0082 16.6 0.0 0.014 15.8 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 CCF32805.1 - 0.03 13.3 0.1 0.054 12.5 0.1 1.5 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family zf_Hakai PF18408.1 CCF32805.1 - 0.21 11.3 0.1 0.77 9.5 0.0 2.0 2 0 0 2 2 2 0 C2H2 Hakai zinc finger domain 5_nucleotid_C PF02872.18 CCF32806.1 - 4.6e-42 143.9 0.0 8.7e-42 143.0 0.0 1.4 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 CCF32806.1 - 3.2e-08 34.3 0.4 5.3e-08 33.6 0.1 1.5 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase YmdB PF13277.6 CCF32806.1 - 0.029 13.7 0.0 0.048 13.0 0.0 1.2 1 0 0 1 1 1 0 YmdB-like protein RskA PF10099.9 CCF32809.1 - 0.01 16.1 0.3 0.014 15.7 0.3 1.2 1 0 0 1 1 1 0 Anti-sigma-K factor rskA Tic110 PF16940.5 CCF32809.1 - 0.062 11.8 1.3 0.075 11.5 1.3 1.0 1 0 0 1 1 1 0 Chloroplast envelope transporter B277 PF17623.2 CCF32809.1 - 0.25 10.4 2.3 0.36 9.9 2.3 1.1 1 0 0 1 1 1 0 Domain of unknown function Wzz PF02706.15 CCF32809.1 - 3.5 8.0 4.1 19 5.7 4.1 2.1 1 1 0 1 1 1 0 Chain length determinant protein Tannase PF07519.11 CCF32811.1 - 3.1e-90 303.3 0.1 3.6e-90 303.1 0.1 1.0 1 0 0 1 1 1 1 Tannase and feruloyl esterase Peptidase_S9 PF00326.21 CCF32811.1 - 0.00047 19.7 0.0 0.19 11.2 0.1 2.3 2 0 0 2 2 2 2 Prolyl oligopeptidase family AAA PF00004.29 CCF32812.1 - 5.4e-06 26.9 0.0 8.7e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 CCF32812.1 - 0.00049 20.6 0.0 0.00094 19.7 0.0 1.4 1 0 0 1 1 1 1 ABC transporter TsaE PF02367.17 CCF32812.1 - 0.00085 19.3 0.0 0.0014 18.6 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Cytidylate_kin PF02224.18 CCF32812.1 - 0.0033 17.2 0.0 0.0058 16.4 0.0 1.4 1 0 0 1 1 1 1 Cytidylate kinase AAA_28 PF13521.6 CCF32812.1 - 0.0036 17.6 0.0 0.0061 16.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CCF32812.1 - 0.0037 17.8 0.0 0.0085 16.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CCF32812.1 - 0.0054 17.0 0.3 0.04 14.2 0.1 2.2 1 1 1 2 2 2 1 AAA domain T2SSE PF00437.20 CCF32812.1 - 0.0057 15.8 0.0 0.009 15.1 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_16 PF13191.6 CCF32812.1 - 0.012 15.9 0.1 0.022 15.1 0.1 1.5 1 1 0 1 1 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 CCF32812.1 - 0.016 15.1 0.0 0.036 14.0 0.0 1.5 2 0 0 2 2 1 0 RsgA GTPase Viral_helicase1 PF01443.18 CCF32812.1 - 0.016 14.9 0.0 0.027 14.2 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase PduV-EutP PF10662.9 CCF32812.1 - 0.018 14.8 0.1 0.031 14.0 0.1 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation NACHT PF05729.12 CCF32812.1 - 0.021 14.7 0.0 0.056 13.4 0.0 1.7 1 0 0 1 1 1 0 NACHT domain AAA_33 PF13671.6 CCF32812.1 - 0.021 15.0 0.0 0.039 14.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 CCF32812.1 - 0.022 14.5 0.0 0.035 13.8 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_17 PF13207.6 CCF32812.1 - 0.027 14.9 0.0 0.044 14.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 CCF32812.1 - 0.031 14.7 0.0 0.063 13.7 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_29 PF13555.6 CCF32812.1 - 0.055 13.2 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_5 PF07728.14 CCF32812.1 - 0.077 13.0 0.1 0.18 11.8 0.1 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) PhoH PF02562.16 CCF32812.1 - 0.091 12.2 0.1 0.15 11.5 0.1 1.3 1 0 0 1 1 1 0 PhoH-like protein AAA_23 PF13476.6 CCF32812.1 - 0.12 12.9 0.0 0.21 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 CCF32812.1 - 0.17 11.9 0.0 0.26 11.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 CCF32812.1 - 0.18 11.0 0.0 0.26 10.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) NB-ARC PF00931.22 CCF32812.1 - 0.18 11.0 0.0 0.3 10.3 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain ATP_bind_1 PF03029.17 CCF32812.1 - 0.19 11.5 0.0 0.29 10.9 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_25 PF13481.6 CCF32812.1 - 0.2 11.2 0.7 0.61 9.6 0.6 1.8 1 1 1 2 2 2 0 AAA domain Rad17 PF03215.15 CCF32812.1 - 0.2 11.5 0.0 0.34 10.8 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain RSN1_7TM PF02714.15 CCF32813.1 - 4.5e-65 219.7 24.5 4.5e-65 219.7 24.5 1.6 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 CCF32813.1 - 1.6e-38 132.7 0.0 2.3e-38 132.2 0.0 1.2 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter RSN1_TM PF13967.6 CCF32813.1 - 1.3e-34 119.2 3.4 1.3e-34 119.2 3.4 2.7 3 0 0 3 3 3 1 Late exocytosis, associated with Golgi transport 2-Hacid_dh_C PF02826.19 CCF32814.1 - 3.4e-55 186.2 0.0 5.1e-55 185.6 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CCF32814.1 - 8.2e-33 112.9 0.0 1.1e-32 112.5 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 CCF32814.1 - 2.3e-07 31.1 0.0 1e-06 29.0 0.0 1.9 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase AlaDh_PNT_C PF01262.21 CCF32814.1 - 0.00012 21.5 0.4 0.01 15.1 0.4 2.4 1 1 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain CoA_binding_2 PF13380.6 CCF32814.1 - 0.0024 18.4 0.0 0.0066 16.9 0.0 1.7 1 0 0 1 1 1 1 CoA binding domain IlvN PF07991.12 CCF32814.1 - 0.0064 16.1 0.0 0.043 13.4 0.0 2.1 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain AdoHcyase_NAD PF00670.21 CCF32814.1 - 0.014 15.5 0.0 0.034 14.2 0.0 1.6 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Oxidored_nitro PF00148.19 CCF32814.1 - 0.082 11.6 0.0 0.097 11.4 0.0 1.1 1 0 0 1 1 1 0 Nitrogenase component 1 type Oxidoreductase HisG_C PF08029.11 CCF32814.1 - 0.094 12.9 0.1 0.24 11.6 0.0 1.6 2 0 0 2 2 2 0 HisG, C-terminal domain GFO_IDH_MocA PF01408.22 CCF32814.1 - 0.14 13.0 3.0 2 9.3 0.1 3.1 2 1 0 2 2 2 0 Oxidoreductase family, NAD-binding Rossmann fold Semialdhyde_dh PF01118.24 CCF32814.1 - 1.2 9.6 3.0 24 5.4 0.1 2.4 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain MFS_1 PF07690.16 CCF32815.1 - 1.7e-41 142.3 27.4 1.7e-41 142.3 27.4 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 CCF32815.1 - 3.3e-08 32.4 3.2 4.7e-08 31.9 3.2 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 CCF32815.1 - 1.1e-07 31.2 21.8 3.4e-07 29.5 21.8 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter DUF3169 PF11368.8 CCF32815.1 - 2.7 7.5 9.6 1.5 8.3 0.7 3.5 3 2 1 4 4 4 0 Protein of unknown function (DUF3169) Asp PF00026.23 CCF32816.1 - 1.5e-70 238.1 4.3 1.8e-70 237.9 4.3 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCF32816.1 - 4.6e-12 46.5 2.6 8.7e-10 39.1 2.6 2.4 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 CCF32816.1 - 0.0017 19.0 1.1 0.3 11.8 0.2 3.4 2 2 0 2 2 2 1 Aspartyl protease Methyltransf_25 PF13649.6 CCF32817.1 - 5.4e-12 46.3 0.0 1.3e-11 45.0 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF32817.1 - 1.1e-10 41.6 0.0 1.4e-10 41.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF32817.1 - 1.9e-08 34.8 0.0 5.8e-08 33.3 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain PCMT PF01135.19 CCF32817.1 - 1e-06 28.7 0.0 1.9e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_12 PF08242.12 CCF32817.1 - 1.9e-05 25.3 0.0 3.6e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF32817.1 - 0.00017 21.5 0.0 0.00025 20.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CCF32817.1 - 0.003 17.1 0.1 0.0055 16.3 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.18 CCF32817.1 - 0.0051 16.2 0.0 0.007 15.7 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PrmA PF06325.13 CCF32817.1 - 0.011 15.2 0.2 0.015 14.7 0.2 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) UPF0020 PF01170.18 CCF32817.1 - 0.044 13.4 0.0 5.8 6.5 0.0 2.3 2 0 0 2 2 2 0 Putative RNA methylase family UPF0020 DDE_Tnp_IS66_C PF13817.6 CCF32817.1 - 0.075 13.3 0.0 0.16 12.2 0.0 1.6 1 0 0 1 1 1 0 IS66 C-terminal element Amidase PF01425.21 CCF32818.1 - 1.2e-92 311.3 0.0 2e-92 310.5 0.0 1.3 1 1 0 1 1 1 1 Amidase DAHP_synth_2 PF01474.16 CCF32819.1 - 5.4e-202 671.1 0.0 6.1e-202 670.9 0.0 1.0 1 0 0 1 1 1 1 Class-II DAHP synthetase family Aa_trans PF01490.18 CCF32821.1 - 4e-36 124.6 33.4 4.6e-36 124.4 33.4 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Abhydrolase_1 PF00561.20 CCF32822.1 - 3.8e-13 49.7 0.0 1e-08 35.2 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCF32822.1 - 6e-09 36.8 0.1 7.2e-09 36.6 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCF32822.1 - 4e-06 26.3 0.0 0.0029 16.9 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Ndr PF03096.14 CCF32822.1 - 0.00094 18.0 0.0 0.0024 16.6 0.0 1.6 2 0 0 2 2 2 1 Ndr family Peptidase_M16_C PF05193.21 CCF32823.1 - 2.7e-59 200.2 0.0 4.9e-59 199.4 0.0 1.4 1 0 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 CCF32823.1 - 3.4e-39 134.2 0.0 1e-38 132.7 0.0 1.8 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Jun PF03957.13 CCF32823.1 - 0.071 13.0 4.6 0.13 12.1 4.6 1.4 1 0 0 1 1 1 0 Jun-like transcription factor S1 PF00575.23 CCF32825.1 - 9e-07 29.2 7.9 0.23 11.8 0.1 5.1 5 0 0 5 5 5 3 S1 RNA binding domain 4HBT_3 PF13622.6 CCF32826.1 - 2.3e-80 270.4 0.3 2.7e-80 270.2 0.3 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.15 CCF32826.1 - 3.2e-25 88.5 0.0 2.9e-10 40.1 0.0 4.1 3 1 0 3 3 3 3 Acyl-CoA thioesterase Oxysterol_BP PF01237.18 CCF32827.1 - 3.2e-136 454.0 0.0 3.2e-136 454.0 0.0 2.7 3 0 0 3 3 3 1 Oxysterol-binding protein Ank PF00023.30 CCF32827.1 - 1.8e-16 59.8 0.1 6.3e-05 23.2 0.0 3.8 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 CCF32827.1 - 8.8e-16 57.8 0.1 1.8e-08 34.4 0.0 3.5 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 CCF32827.1 - 4.9e-15 55.9 0.1 4.1e-10 40.1 0.0 2.8 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CCF32827.1 - 2.4e-13 50.3 0.0 7.5e-08 32.8 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCF32827.1 - 2.7e-12 45.7 0.0 0.00072 19.8 0.0 3.8 3 0 0 3 3 3 2 Ankyrin repeat PH PF00169.29 CCF32827.1 - 2.9e-11 43.8 0.8 5.9e-11 42.8 0.8 1.5 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 CCF32827.1 - 1.5e-07 31.6 1.0 3.9e-07 30.3 1.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 CCF32827.1 - 2.9e-05 24.5 2.6 7.8e-05 23.1 2.6 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain Zip PF02535.22 CCF32828.1 - 3.4e-32 112.0 21.0 3.3e-26 92.3 3.4 3.9 2 1 1 3 3 3 3 ZIP Zinc transporter Hat1_N PF10394.9 CCF32829.1 - 1e-43 149.4 0.0 2.5e-43 148.1 0.0 1.7 2 0 0 2 2 2 1 Histone acetyl transferase HAT1 N-terminus Acetyltransf_10 PF13673.7 CCF32829.1 - 0.00031 20.7 0.0 0.00093 19.1 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CCF32829.1 - 0.00097 19.4 0.0 0.0025 18.0 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CCF32829.1 - 0.016 15.6 0.0 0.038 14.4 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain EHN PF06441.12 CCF32831.1 - 2.9e-26 92.0 1.0 5.4e-26 91.1 1.0 1.5 1 0 0 1 1 1 1 Epoxide hydrolase N terminus TaqI_C PF12950.7 CCF32831.1 - 0.0026 17.8 0.0 0.004 17.2 0.0 1.2 1 0 0 1 1 1 1 TaqI-like C-terminal specificity domain TIMELESS PF04821.14 CCF32832.1 - 1.6e-87 293.3 0.0 1.6e-87 293.3 0.0 2.1 3 0 0 3 3 3 1 Timeless protein TIMELESS_C PF05029.13 CCF32832.1 - 8.4e-35 121.0 6.1 8.4e-35 121.0 6.1 3.0 2 1 1 3 3 3 1 Timeless protein C terminal region Nfu_N PF08712.11 CCF32832.1 - 0.015 15.3 0.3 0.055 13.5 0.0 2.1 2 0 0 2 2 2 0 Scaffold protein Nfu/NifU N terminal U1snRNP70_N PF12220.8 CCF32832.1 - 3.7 8.3 8.1 16 6.2 4.5 3.2 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal 3HCDH_N PF02737.18 CCF32833.1 - 3.3e-52 177.0 0.6 4.3e-52 176.6 0.6 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 CCF32833.1 - 2.3e-34 117.9 0.0 4.8e-34 116.8 0.0 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain Sacchrp_dh_NADP PF03435.18 CCF32833.1 - 5e-05 23.6 0.1 9.8e-05 22.6 0.1 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_2 PF03446.15 CCF32833.1 - 0.00071 19.8 0.1 0.0022 18.2 0.1 1.8 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase DAO PF01266.24 CCF32833.1 - 0.0021 17.7 0.0 0.0025 17.4 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCF32833.1 - 0.0084 15.4 0.0 0.011 15.0 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase UDPG_MGDP_dh_N PF03721.14 CCF32833.1 - 0.03 13.9 0.1 0.052 13.1 0.1 1.5 1 1 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain AlaDh_PNT_C PF01262.21 CCF32833.1 - 0.035 13.4 0.3 0.073 12.4 0.3 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain TrkA_N PF02254.18 CCF32833.1 - 0.11 12.8 0.0 0.94 9.8 0.0 2.2 2 0 0 2 2 2 0 TrkA-N domain F420_oxidored PF03807.17 CCF32833.1 - 0.26 11.9 1.9 1.4 9.6 1.9 2.3 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent SMI1_KNR4 PF09346.10 CCF32834.1 - 2.9e-19 69.8 0.1 7.8e-19 68.4 0.1 1.7 1 1 0 1 1 1 1 SMI1 / KNR4 family (SUKH-1) UPF0220 PF05255.11 CCF32835.1 - 2.5e-67 225.6 4.0 2.8e-67 225.4 4.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) zf-RING_UBOX PF13445.6 CCF32836.1 - 0.11 12.5 0.0 0.24 11.4 0.0 1.5 1 0 0 1 1 1 0 RING-type zinc-finger SWIM PF04434.17 CCF32837.1 - 1.4e-05 24.7 0.7 3.2e-05 23.5 0.1 1.9 2 0 0 2 2 2 1 SWIM zinc finger Sulfate_transp PF00916.20 CCF32838.1 - 2e-108 362.5 25.4 2.6e-108 362.2 25.4 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 CCF32838.1 - 3.9e-09 36.2 0.0 7.7e-09 35.2 0.0 1.4 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 CCF32838.1 - 0.00039 20.8 18.1 0.004 17.5 3.8 3.3 2 2 1 3 3 3 2 Molybdate transporter of MFS superfamily SNN_transmemb PF09049.10 CCF32838.1 - 0.094 12.7 1.4 0.62 10.1 1.4 2.5 1 0 0 1 1 1 0 Stannin transmembrane p450 PF00067.22 CCF32839.1 - 4.2e-32 111.5 0.0 6.1e-32 111.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 ketoacyl-synt PF00109.26 CCF32840.1 - 5.3e-78 262.1 0.0 1.4e-77 260.7 0.0 1.8 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 CCF32840.1 - 2.9e-44 151.9 0.0 5.1e-44 151.1 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain PS-DH PF14765.6 CCF32840.1 - 6.2e-43 147.1 0.0 1e-42 146.4 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase Ketoacyl-synt_C PF02801.22 CCF32840.1 - 1.6e-27 95.9 0.2 9.8e-27 93.3 0.0 2.5 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 CCF32840.1 - 2.6e-15 56.8 0.0 5.9e-15 55.7 0.0 1.6 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Thiolase_N PF00108.23 CCF32840.1 - 6.2e-06 25.8 0.1 1.7e-05 24.3 0.0 1.7 2 0 0 2 2 2 1 Thiolase, N-terminal domain ACP_syn_III PF08545.10 CCF32840.1 - 0.22 11.4 2.2 0.37 10.7 0.3 2.4 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Arylsulfotran_2 PF14269.6 CCF32841.1 - 4.4e-74 249.5 1.0 5.6e-74 249.2 1.0 1.1 1 0 0 1 1 1 1 Arylsulfotransferase (ASST) Arylsulfotrans PF05935.11 CCF32841.1 - 2.8e-14 52.8 0.1 4.5e-13 48.9 0.1 2.0 1 1 0 1 1 1 1 Arylsulfotransferase (ASST) DUF3824 PF12868.7 CCF32843.1 - 2.1e-07 31.7 41.1 2.1e-07 31.7 41.1 9.5 4 4 4 8 8 8 3 Domain of unknwon function (DUF3824) DUF4179 PF13786.6 CCF32843.1 - 0.32 11.5 0.9 3.1 8.3 0.0 2.8 4 0 0 4 4 4 0 Domain of unknown function (DUF4179) CopD PF05425.13 CCF32843.1 - 0.44 11.0 5.0 0.53 10.7 0.3 2.9 3 0 0 3 3 3 0 Copper resistance protein D Phage_holin_3_3 PF16083.5 CCF32843.1 - 4.4 7.5 4.7 8.5 6.6 0.5 3.4 2 2 1 3 3 3 0 LydA holin phage, holin superfamily III DnaJ PF00226.31 CCF32844.1 - 4.5e-26 90.7 1.1 7.4e-26 90.1 1.1 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_C PF01556.18 CCF32844.1 - 5.7e-24 84.9 0.0 8.5e-24 84.3 0.0 1.3 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 CCF32844.1 - 5.9e-13 49.0 18.6 1.1e-12 48.1 18.6 1.5 1 0 0 1 1 1 1 DnaJ central domain HypA PF01155.19 CCF32844.1 - 0.0023 17.9 7.1 0.22 11.5 1.2 2.3 2 0 0 2 2 2 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Anti-TRAP PF15777.5 CCF32844.1 - 0.14 12.1 8.3 2 8.5 0.5 2.4 2 0 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein ADK_lid PF05191.14 CCF32844.1 - 0.47 10.5 4.1 51 4.0 0.0 3.9 3 0 0 3 3 3 0 Adenylate kinase, active site lid OB_NTP_bind PF07717.16 CCF32845.1 - 2.1e-21 76.0 0.0 5.1e-21 74.8 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 CCF32845.1 - 4.6e-19 68.7 0.1 4.6e-19 68.7 0.1 4.0 3 1 0 3 3 2 1 Helicase associated domain (HA2) Helicase_C PF00271.31 CCF32845.1 - 6.3e-15 55.5 0.0 1.7e-14 54.1 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 CCF32845.1 - 1.8e-05 24.6 0.0 4.5e-05 23.3 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 CCF32845.1 - 2.4e-05 24.6 0.8 6.9e-05 23.1 0.0 2.2 3 0 0 3 3 3 1 AAA domain AAA_30 PF13604.6 CCF32845.1 - 0.00095 18.9 0.0 0.0026 17.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 CCF32845.1 - 0.0018 17.4 0.0 0.0048 16.0 0.0 1.7 1 0 0 1 1 1 1 Type II/IV secretion system protein SRP54 PF00448.22 CCF32845.1 - 0.0069 16.0 0.3 0.018 14.6 0.3 1.7 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_19 PF13245.6 CCF32845.1 - 0.047 14.0 1.0 0.082 13.2 0.1 1.8 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 CCF32845.1 - 0.16 12.0 2.3 2.4 8.2 0.1 3.2 2 1 0 2 2 2 0 AAA domain ABC_tran PF00005.27 CCF32845.1 - 0.34 11.4 0.0 0.34 11.4 0.0 2.8 3 0 0 3 3 3 0 ABC transporter Chorion_2 PF03964.15 CCF32847.1 - 7.9 7.4 10.5 6.4 7.7 4.3 2.6 2 0 0 2 2 2 0 Chorion family 2 Egh16-like PF11327.8 CCF32848.1 - 1.4e-65 221.1 9.9 2e-65 220.6 9.9 1.2 1 0 0 1 1 1 1 Egh16-like virulence factor Cupin_8 PF13621.6 CCF32850.1 - 1.4e-69 234.7 0.1 1.6e-69 234.5 0.1 1.0 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 CCF32850.1 - 2.3e-06 27.3 0.0 0.00044 19.8 0.1 2.2 2 0 0 2 2 2 2 Cupin superfamily protein JmjC PF02373.22 CCF32850.1 - 0.1 13.0 0.2 1.4 9.4 0.0 2.6 3 0 0 3 3 3 0 JmjC domain, hydroxylase N-SET PF11764.8 CCF32851.1 - 2.7e-44 151.3 0.5 2.7e-44 151.3 0.5 2.3 2 0 0 2 2 2 1 COMPASS (Complex proteins associated with Set1p) component N SET_assoc PF11767.8 CCF32851.1 - 1.4e-25 88.7 0.7 1.4e-25 88.7 0.7 2.6 3 0 0 3 3 3 1 Histone lysine methyltransferase SET associated SET PF00856.28 CCF32851.1 - 3.3e-18 66.7 0.1 3.3e-18 66.7 0.1 3.1 3 1 0 3 3 3 1 SET domain RRM_1 PF00076.22 CCF32851.1 - 0.036 13.9 0.3 1.4 8.8 0.0 2.8 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ZapB PF06005.12 CCF32853.1 - 0.046 14.2 3.0 0.42 11.1 0.1 2.8 3 0 0 3 3 3 0 Cell division protein ZapB MbeD_MobD PF04899.12 CCF32853.1 - 0.33 11.1 0.1 0.33 11.1 0.1 2.4 3 0 0 3 3 3 0 MbeD/MobD like Pup PF05639.11 CCF32853.1 - 4.4 8.3 6.3 4.2 8.4 0.1 2.8 3 0 0 3 3 3 0 Pup-like protein Kelch_6 PF13964.6 CCF32854.1 - 9e-38 127.4 8.2 1.9e-08 34.3 0.0 6.3 5 2 1 6 6 6 5 Kelch motif Kelch_1 PF01344.25 CCF32854.1 - 3.4e-35 119.4 8.7 5.6e-08 32.2 0.2 6.3 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.6 CCF32854.1 - 5.7e-35 119.1 6.4 1.2e-07 31.6 0.2 5.4 4 1 1 5 5 5 5 Galactose oxidase, central domain Kelch_3 PF13415.6 CCF32854.1 - 2e-23 82.1 13.2 7.6e-06 26.1 0.0 6.3 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_2 PF07646.15 CCF32854.1 - 7.7e-20 70.0 15.0 0.00018 21.4 0.2 6.8 6 3 0 6 6 6 4 Kelch motif Kelch_5 PF13854.6 CCF32854.1 - 2.2e-19 69.0 10.2 1.5e-06 28.0 0.1 6.3 6 0 0 6 6 6 6 Kelch motif EFP_N PF08207.12 CCF32854.1 - 0.12 12.5 0.0 0.49 10.5 0.0 1.9 2 0 0 2 2 2 0 Elongation factor P (EF-P) KOW-like domain DUF5122 PF17164.4 CCF32854.1 - 0.33 11.3 6.3 4 7.8 0.6 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF5122) beta-propeller PQQ_3 PF13570.6 CCF32854.1 - 0.92 10.1 13.2 3.7 8.2 0.2 4.4 3 1 1 4 4 4 0 PQQ-like domain MFS_1 PF07690.16 CCF32855.1 - 9.8e-44 149.7 29.2 9.8e-44 149.7 29.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Glyco_hydro_61 PF03443.14 CCF32856.1 - 7.8e-58 195.8 0.0 9.2e-58 195.6 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 DUF4469 PF14734.6 CCF32856.1 - 0.14 12.3 0.0 0.32 11.2 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4469) with IG-like fold DUF1769 PF08588.10 CCF32857.1 - 4.5e-27 94.0 0.5 1.2e-26 92.6 0.2 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1769) DUF3506 PF12014.8 CCF32858.1 - 7.7e-53 178.2 0.0 1.2e-52 177.6 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3506) Glyco_hydro_43 PF04616.14 CCF32859.1 - 2.1e-64 217.6 8.9 1.3e-56 192.1 2.0 2.3 2 0 0 2 2 2 2 Glycosyl hydrolases family 43 Laminin_G_3 PF13385.6 CCF32859.1 - 7.4e-20 71.6 1.8 3.3e-19 69.5 1.8 2.2 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Glyco_hydro_32N PF00251.20 CCF32859.1 - 9.6e-08 31.9 3.1 0.00061 19.5 0.3 2.9 3 0 0 3 3 3 2 Glycosyl hydrolases family 32 N-terminal domain Sialidase PF02973.16 CCF32859.1 - 0.0013 18.3 0.2 0.0025 17.4 0.2 1.4 1 0 0 1 1 1 1 Sialidase, N-terminal domain HSP70 PF00012.20 CCF32860.1 - 5e-259 860.5 5.3 5.7e-259 860.3 5.3 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 CCF32860.1 - 4.8e-17 61.8 0.1 1.1e-15 57.3 0.0 2.1 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 CCF32860.1 - 0.00055 19.7 0.0 0.0013 18.5 0.0 1.6 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.6 CCF32860.1 - 0.0023 18.3 0.8 4 7.9 0.0 3.2 3 1 0 3 3 3 2 Cell division protein FtsA Hydantoinase_A PF01968.18 CCF32860.1 - 0.016 14.5 0.1 0.04 13.2 0.1 1.7 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase Golgin_A5 PF09787.9 CCF32860.1 - 1.7 8.0 8.3 1.7 8.0 5.7 1.9 2 0 0 2 2 2 0 Golgin subfamily A member 5 MutS_III PF05192.18 CCF32860.1 - 3.8 7.7 5.4 11 6.2 0.7 2.6 2 1 0 2 2 2 0 MutS domain III DUF3128 PF11326.8 CCF32861.1 - 4.3e-28 97.5 5.1 6.6e-28 96.9 5.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3128) RNA12 PF10443.9 CCF32862.1 - 3.9e-161 536.7 3.5 1.2e-160 535.2 1.1 2.0 2 0 0 2 2 2 1 RNA12 protein RRM_1 PF00076.22 CCF32862.1 - 1.6e-05 24.6 0.0 6.8e-05 22.6 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ATPase_2 PF01637.18 CCF32862.1 - 0.00071 19.6 1.0 0.022 14.7 0.8 2.8 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea Strep_SA_rep PF06696.11 CCF32862.1 - 0.23 11.5 0.8 0.6 10.2 0.8 1.6 1 0 0 1 1 1 0 Streptococcal surface antigen repeat peroxidase PF00141.23 CCF32863.1 - 1e-20 74.5 0.5 1.7e-20 73.7 0.5 1.3 1 0 0 1 1 1 1 Peroxidase PSI_PSAK PF01241.18 CCF32863.1 - 0.00032 20.6 0.0 0.0007 19.6 0.0 1.5 1 0 0 1 1 1 1 Photosystem I psaG / psaK NAD_binding_10 PF13460.6 CCF32864.1 - 5.2e-33 114.5 0.2 6.3e-33 114.2 0.2 1.1 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CCF32864.1 - 0.00029 20.4 0.0 0.00047 19.7 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 CCF32864.1 - 0.088 12.4 0.0 1 8.9 0.0 2.0 2 0 0 2 2 2 0 NmrA-like family RmlD_sub_bind PF04321.17 CCF32864.1 - 0.12 11.5 0.0 0.18 10.9 0.0 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain Methyltransf_23 PF13489.6 CCF32865.1 - 2.2e-22 79.6 0.0 3.3e-22 79.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF32865.1 - 8.7e-10 39.2 0.0 1.8e-09 38.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF32865.1 - 8.1e-09 35.4 0.0 5.3e-08 32.8 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF32865.1 - 1.8e-06 28.5 0.0 3.7e-06 27.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF32865.1 - 1.2e-05 25.9 0.0 4.9e-05 24.0 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CCF32865.1 - 0.0056 16.2 0.0 0.034 13.7 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase small domain CopK PF11525.8 CCF32865.1 - 0.007 16.0 0.1 0.017 14.7 0.1 1.6 1 0 0 1 1 1 1 Copper resistance protein K Mito_carr PF00153.27 CCF32866.1 - 1.2e-67 223.9 3.4 7.8e-24 83.4 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF4748 PF15932.5 CCF32866.1 - 0.09 12.6 0.7 0.31 10.8 0.7 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4748) CENP-X PF09415.10 CCF32867.1 - 1e-23 83.4 0.0 1e-23 83.4 0.0 2.3 2 1 1 3 3 3 1 CENP-S associating Centromere protein X AT_hook PF02178.19 CCF32867.1 - 0.033 14.0 0.2 0.12 12.3 0.2 2.0 1 0 0 1 1 1 0 AT hook motif DUF4746 PF15928.5 CCF32867.1 - 0.34 10.3 5.3 0.44 9.9 5.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) PRD1_DD PF11087.8 CCF32869.1 - 0.085 12.6 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 PRD1 phage membrane DNA delivery Hemerythrin PF01814.23 CCF32870.1 - 0.035 14.7 0.6 0.066 13.8 0.6 1.4 1 0 0 1 1 1 0 Hemerythrin HHE cation binding domain AAA PF00004.29 CCF32871.1 - 1.7e-42 144.9 0.0 3e-42 144.2 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 CCF32871.1 - 1.3e-11 44.3 0.2 2.3e-10 40.3 0.0 2.4 2 0 0 2 2 2 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 CCF32871.1 - 4.3e-10 39.2 0.1 8e-10 38.4 0.1 1.4 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 CCF32871.1 - 1.1e-07 32.4 0.0 6.7e-05 23.3 0.1 2.9 2 1 1 3 3 3 1 AAA ATPase domain AAA_5 PF07728.14 CCF32871.1 - 1.9e-06 27.9 0.1 3.8e-05 23.7 0.1 2.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 CCF32871.1 - 2.8e-06 27.6 0.0 9.2e-06 25.9 0.0 1.9 3 0 0 3 3 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 CCF32871.1 - 6.8e-06 25.9 0.0 1.5e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 CCF32871.1 - 0.00022 21.5 0.1 0.006 16.9 0.0 2.4 1 1 1 2 2 2 1 AAA domain DUF815 PF05673.13 CCF32871.1 - 0.00034 19.9 0.0 0.00076 18.7 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_18 PF13238.6 CCF32871.1 - 0.00045 20.8 0.0 0.0021 18.6 0.0 2.2 2 1 0 2 2 2 1 AAA domain AAA_7 PF12775.7 CCF32871.1 - 0.0012 18.4 0.0 0.0023 17.4 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region TIP49 PF06068.13 CCF32871.1 - 0.0023 17.2 0.0 0.0043 16.3 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain Mg_chelatase PF01078.21 CCF32871.1 - 0.0037 16.7 0.0 0.0074 15.7 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 CCF32871.1 - 0.0037 17.4 0.0 0.0089 16.2 0.0 1.7 2 0 0 2 2 1 1 AAA domain TsaE PF02367.17 CCF32871.1 - 0.004 17.1 0.0 0.0097 15.9 0.0 1.6 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE IstB_IS21 PF01695.17 CCF32871.1 - 0.0053 16.5 0.0 0.013 15.3 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein RNA_helicase PF00910.22 CCF32871.1 - 0.0061 16.9 0.0 0.012 16.0 0.0 1.5 1 0 0 1 1 1 1 RNA helicase AAA_14 PF13173.6 CCF32871.1 - 0.0065 16.5 0.0 0.016 15.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain Sigma54_activat PF00158.26 CCF32871.1 - 0.0084 15.8 0.0 0.027 14.2 0.0 1.9 1 1 0 1 1 1 1 Sigma-54 interaction domain eIF-1a PF01176.19 CCF32871.1 - 0.012 15.4 0.0 0.023 14.5 0.0 1.4 1 0 0 1 1 1 0 Translation initiation factor 1A / IF-1 AAA_3 PF07726.11 CCF32871.1 - 0.013 15.4 0.0 0.03 14.2 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_11 PF13086.6 CCF32871.1 - 0.016 15.0 0.6 0.26 11.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 CCF32871.1 - 0.019 14.7 0.0 0.057 13.1 0.0 1.9 2 0 0 2 2 1 0 AAA domain AAA_30 PF13604.6 CCF32871.1 - 0.037 13.8 0.0 0.11 12.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 CCF32871.1 - 0.037 13.4 0.4 0.13 11.5 0.0 2.1 3 0 0 3 3 3 0 KaiC Prot_ATP_OB_N PF17758.1 CCF32871.1 - 0.047 13.4 0.0 0.13 11.9 0.0 1.7 1 0 0 1 1 1 0 Proteasomal ATPase OB N-terminal domain DUF4200 PF13863.6 CCF32871.1 - 0.051 14.0 1.6 0.051 14.0 1.6 1.9 2 0 0 2 2 1 0 Domain of unknown function (DUF4200) NACHT PF05729.12 CCF32871.1 - 0.056 13.4 0.1 0.15 12.0 0.0 1.7 2 0 0 2 2 2 0 NACHT domain PhoH PF02562.16 CCF32871.1 - 0.063 12.7 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein AAA_28 PF13521.6 CCF32871.1 - 0.091 13.0 0.0 0.17 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 CCF32871.1 - 0.092 12.3 0.0 0.22 11.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 CCF32871.1 - 0.12 11.7 0.0 0.26 10.5 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin Parvo_NS1 PF01057.17 CCF32871.1 - 0.13 11.3 0.0 0.22 10.6 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 DUF3450 PF11932.8 CCF32871.1 - 0.39 10.0 2.3 0.64 9.3 2.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) AAA_23 PF13476.6 CCF32871.1 - 0.95 9.9 3.8 23 5.4 0.8 2.7 2 1 0 2 2 2 0 AAA domain MmgE_PrpD PF03972.14 CCF32873.1 - 3.5e-150 500.4 0.0 4.3e-150 500.1 0.0 1.1 1 0 0 1 1 1 1 MmgE/PrpD family KORA PF16509.5 CCF32873.1 - 0.14 12.5 0.1 0.36 11.1 0.1 1.7 1 0 0 1 1 1 0 TrfB plasmid transcriptional repressor SH3_1 PF00018.28 CCF32874.1 - 3.1e-12 45.9 0.0 4.9e-12 45.3 0.0 1.3 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 CCF32874.1 - 5.4e-08 32.6 0.0 8.2e-08 32.0 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 CCF32874.1 - 5.1e-05 22.9 0.0 8.2e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain DUF910 PF06014.11 CCF32874.1 - 0.095 12.7 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF910) CARD PF00619.21 CCF32874.1 - 0.22 11.6 0.0 0.35 10.9 0.0 1.2 1 0 0 1 1 1 0 Caspase recruitment domain DUF2076 PF09849.9 CCF32874.1 - 9 6.3 17.9 1.7 8.7 11.3 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) VHS PF00790.19 CCF32875.1 - 2.3e-36 124.7 0.0 5.2e-36 123.6 0.0 1.5 1 0 0 1 1 1 1 VHS domain SH3_1 PF00018.28 CCF32875.1 - 7.4e-17 60.7 0.1 1.9e-16 59.4 0.1 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 CCF32875.1 - 2.8e-15 55.9 1.2 3.9e-15 55.4 0.1 1.9 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 CCF32875.1 - 5e-14 51.7 0.1 1.1e-13 50.6 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain GAT PF03127.14 CCF32875.1 - 8.6e-11 42.0 2.6 1.1e-10 41.6 1.0 2.0 2 0 0 2 2 2 1 GAT domain UIM PF02809.20 CCF32875.1 - 0.0076 16.1 3.3 0.0076 16.1 3.3 1.9 2 0 0 2 2 2 1 Ubiquitin interaction motif DUF3361 PF11841.8 CCF32875.1 - 0.25 11.3 0.4 0.51 10.3 0.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3361) DUF4375 PF14300.6 CCF32875.1 - 1.7 9.0 3.5 1.5 9.1 0.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4375) SNF2_N PF00176.23 CCF32876.1 - 4.8e-69 232.7 2.0 5.1e-67 226.0 2.0 2.9 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CCF32876.1 - 1.2e-18 67.5 0.1 9.6e-18 64.6 0.1 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCF32876.1 - 4.2e-06 26.9 0.0 1.2e-05 25.4 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 CCF32876.1 - 5.8e-06 26.2 0.1 1.6e-05 24.8 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Ran-binding PF05508.11 CCF32877.1 - 4.6e-117 390.5 0.0 5.9e-117 390.1 0.0 1.1 1 0 0 1 1 1 1 RanGTP-binding protein GTP_EFTU PF00009.27 CCF32878.1 - 1.3e-43 148.8 0.0 2.1e-43 148.1 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 CCF32878.1 - 1.4e-29 102.6 0.6 4.2e-29 101.1 0.0 2.2 3 0 0 3 3 3 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 CCF32878.1 - 1.5e-09 38.1 2.6 6.7e-09 36.0 0.4 2.6 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CCF32878.1 - 0.0031 17.6 0.0 0.022 14.8 0.0 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase Fungal_trans PF04082.18 CCF32880.1 - 1.8e-14 53.4 0.3 5.7e-14 51.8 0.1 1.9 2 0 0 2 2 2 1 Fungal specific transcription factor domain Transp_inhibit PF18791.1 CCF32880.1 - 0.12 11.8 0.0 0.24 10.9 0.0 1.4 1 0 0 1 1 1 0 Transport inhibitor response 1 protein domain zf-C2H2_jaz PF12171.8 CCF32881.1 - 6.1e-07 29.6 3.2 1e-06 28.8 3.2 1.4 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CCF32881.1 - 0.00052 20.3 1.0 0.00092 19.5 1.0 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 CCF32881.1 - 0.043 14.2 0.4 0.067 13.5 0.4 1.3 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 CCF32881.1 - 0.049 14.5 0.4 0.096 13.6 0.4 1.5 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2 PF00096.26 CCF32881.1 - 0.054 14.0 0.9 0.091 13.3 0.9 1.4 1 0 0 1 1 1 0 Zinc finger, C2H2 type DUF1691 PF07950.11 CCF32882.1 - 2.7e-40 137.4 8.9 3.4e-33 114.6 5.8 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF1691) CFEM PF05730.11 CCF32883.1 - 7.2e-10 38.8 15.3 8.6e-10 38.6 15.3 1.1 1 0 0 1 1 1 1 CFEM domain PAN_4 PF14295.6 CCF32884.1 - 0.008 16.1 1.7 0.018 14.9 1.7 1.5 1 0 0 1 1 1 1 PAN domain PAN_1 PF00024.26 CCF32884.1 - 0.014 15.3 0.2 0.027 14.4 0.2 1.4 1 0 0 1 1 1 0 PAN domain RAC_head PF16717.5 CCF32885.1 - 7.5e-32 110.2 1.4 7.5e-32 110.2 1.4 4.0 3 1 0 3 3 3 1 Ribosome-associated complex head domain DnaJ PF00226.31 CCF32885.1 - 7.4e-19 67.6 1.3 7.4e-19 67.6 1.3 2.5 3 0 0 3 3 3 1 DnaJ domain V_ATPase_I PF01496.19 CCF32885.1 - 0.25 9.2 7.7 0.46 8.3 7.7 1.4 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RRM_1 PF00076.22 CCF32886.1 - 3.6e-10 39.5 0.0 6e-10 38.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CCF32886.1 - 0.00039 20.2 0.0 0.00059 19.6 0.0 1.2 1 0 0 1 1 1 1 Occluded RNA-recognition motif RRM_3 PF08777.11 CCF32886.1 - 0.00096 19.2 0.0 0.0019 18.2 0.0 1.4 1 0 0 1 1 1 1 RNA binding motif Nup35_RRM_2 PF14605.6 CCF32886.1 - 0.0015 18.5 0.0 0.0026 17.7 0.0 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Sterol_MT_C PF08498.10 CCF32887.1 - 1.6e-28 98.8 0.4 2.8e-28 98.0 0.4 1.4 1 0 0 1 1 1 1 Sterol methyltransferase C-terminal Methyltransf_11 PF08241.12 CCF32887.1 - 5e-22 78.4 0.0 9.4e-22 77.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF32887.1 - 1.4e-20 73.7 0.0 3.3e-20 72.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF32887.1 - 3.4e-18 65.9 0.0 5.3e-18 65.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF32887.1 - 1.2e-12 48.0 0.0 2e-12 47.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 CCF32887.1 - 1.3e-11 44.3 0.1 1.9e-11 43.8 0.1 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.12 CCF32887.1 - 3.7e-11 43.6 0.1 1e-10 42.2 0.0 1.8 2 0 0 2 2 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCF32887.1 - 9.2e-11 41.5 0.0 1.7e-10 40.6 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_29 PF03141.16 CCF32887.1 - 0.00057 18.6 0.0 0.00083 18.0 0.0 1.2 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_15 PF09445.10 CCF32887.1 - 0.00099 18.7 0.0 0.0016 18.1 0.0 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase PCMT PF01135.19 CCF32887.1 - 0.001 18.9 0.0 0.0017 18.2 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MetW PF07021.12 CCF32887.1 - 0.0016 18.1 0.0 0.0027 17.3 0.0 1.4 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW MTS PF05175.14 CCF32887.1 - 0.0029 17.2 0.0 0.0053 16.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain RrnaAD PF00398.20 CCF32887.1 - 0.0033 16.5 0.0 0.0051 15.9 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase PrmA PF06325.13 CCF32887.1 - 0.0045 16.4 0.0 0.0092 15.4 0.0 1.4 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_2 PF00891.18 CCF32887.1 - 0.0072 15.6 0.0 0.012 14.9 0.0 1.4 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_32 PF13679.6 CCF32887.1 - 0.011 15.7 0.1 0.022 14.7 0.0 1.5 2 0 0 2 2 2 0 Methyltransferase domain TehB PF03848.14 CCF32887.1 - 0.02 14.3 0.0 0.04 13.3 0.0 1.5 1 0 0 1 1 1 0 Tellurite resistance protein TehB PHBC_N PF12551.8 CCF32887.1 - 0.11 12.3 1.2 0.26 11.1 0.1 2.2 2 0 0 2 2 2 0 Poly-beta-hydroxybutyrate polymerase N terminal Transket_pyr PF02779.24 CCF32888.1 - 1.5e-45 155.1 0.0 2e-45 154.7 0.0 1.2 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 CCF32888.1 - 4e-36 123.6 0.1 1.2e-35 122.1 0.1 1.8 2 0 0 2 2 2 1 Transketolase, C-terminal domain DSHCT PF08148.12 CCF32889.1 - 1.9e-52 177.2 0.2 4.1e-52 176.1 0.2 1.6 1 0 0 1 1 1 1 DSHCT (NUC185) domain Ski2_N PF17911.1 CCF32889.1 - 1.3e-39 135.1 0.0 8.6e-39 132.4 0.0 2.2 2 0 0 2 2 2 1 Ski2 N-terminal region rRNA_proc-arch PF13234.6 CCF32889.1 - 1.8e-30 106.8 0.0 3e-30 106.1 0.0 1.4 1 0 0 1 1 1 1 rRNA-processing arch domain DEAD PF00270.29 CCF32889.1 - 8e-19 68.1 0.0 1.7e-18 67.0 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF32889.1 - 3.2e-06 27.4 0.0 1.3e-05 25.5 0.0 2.2 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCF32889.1 - 1e-05 25.6 0.1 7.6e-05 22.8 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF3516 PF12029.8 CCF32889.1 - 0.21 10.6 1.6 0.23 10.5 0.3 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3516) Snf7 PF03357.21 CCF32890.1 - 2.2e-06 27.4 25.9 2.2e-06 27.4 25.9 1.5 1 1 0 1 1 1 1 Snf7 Ist1 PF03398.14 CCF32890.1 - 0.0012 18.8 7.9 0.0025 17.8 7.9 1.5 1 1 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway CEL_III_C PF18054.1 CCF32890.1 - 2.4 8.2 6.3 3.6 7.6 6.3 1.4 1 0 0 1 1 1 0 CEL-III C-terminal RFamide_26RFa PF11109.8 CCF32890.1 - 2.6 8.6 10.2 0.16 12.5 1.9 2.1 1 1 1 2 2 2 0 Orexigenic neuropeptide Qrfp/P518 NTP_transf_9 PF04248.12 CCF32891.1 - 4.2e-33 113.1 0.5 5.5e-33 112.7 0.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF427) AAA PF00004.29 CCF32893.1 - 3.7e-11 43.6 0.0 7.8e-11 42.5 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CCF32893.1 - 6.6e-07 29.7 0.0 1.8e-06 28.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 CCF32893.1 - 2.7e-05 24.2 0.0 5.5e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 CCF32893.1 - 6.5e-05 22.7 0.0 0.00013 21.7 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Rad17 PF03215.15 CCF32893.1 - 6.9e-05 22.8 0.0 0.00018 21.5 0.0 1.7 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_16 PF13191.6 CCF32893.1 - 0.00076 19.9 0.0 0.0027 18.1 0.0 2.0 1 0 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 CCF32893.1 - 0.0035 17.5 0.2 0.014 15.6 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 CCF32893.1 - 0.0043 17.1 0.0 0.0082 16.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CCF32893.1 - 0.0061 16.3 0.1 0.014 15.1 0.1 1.5 1 0 0 1 1 1 1 AAA domain NB-ARC PF00931.22 CCF32893.1 - 0.018 14.2 0.0 0.033 13.4 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain NTPase_1 PF03266.15 CCF32893.1 - 0.02 14.8 0.3 0.11 12.4 0.1 2.4 2 1 1 3 3 3 0 NTPase AAA_25 PF13481.6 CCF32893.1 - 0.045 13.3 0.1 0.73 9.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 CCF32893.1 - 0.054 14.1 0.0 0.12 12.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 CCF32893.1 - 0.073 13.4 0.3 0.47 10.8 0.4 2.3 2 1 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 CCF32893.1 - 0.081 12.8 0.0 0.18 11.7 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase ABC_tran PF00005.27 CCF32893.1 - 0.1 13.1 0.0 0.3 11.6 0.0 1.8 1 0 0 1 1 1 0 ABC transporter AAA_17 PF13207.6 CCF32893.1 - 0.1 13.0 0.0 0.37 11.2 0.0 2.0 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 CCF32893.1 - 0.13 12.3 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE IstB_IS21 PF01695.17 CCF32893.1 - 0.18 11.5 0.1 0.54 10.0 0.1 1.8 1 1 0 1 1 1 0 IstB-like ATP binding protein HIT PF01230.23 CCF32894.1 - 5.7e-21 75.1 0.0 1.1e-20 74.1 0.0 1.4 2 0 0 2 2 2 1 HIT domain DcpS_C PF11969.8 CCF32894.1 - 0.00062 20.2 0.0 0.0015 19.0 0.0 1.6 1 1 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding Glyco_hydro_106 PF17132.4 CCF32894.1 - 0.087 11.1 0.0 2.5 6.3 0.0 2.0 2 0 0 2 2 2 0 alpha-L-rhamnosidase Ferrochelatase PF00762.19 CCF32895.1 - 1.3e-96 323.4 0.0 1.6e-96 323.2 0.0 1.0 1 0 0 1 1 1 1 Ferrochelatase Ku_N PF03731.15 CCF32896.1 - 1.9e-14 53.9 0.0 2.6e-14 53.5 0.0 1.2 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain VWA_2 PF13519.6 CCF32896.1 - 0.027 15.1 0.0 0.046 14.4 0.0 1.3 1 0 0 1 1 1 0 von Willebrand factor type A domain VWA PF00092.28 CCF32896.1 - 0.13 12.5 0.0 0.2 11.9 0.0 1.3 1 0 0 1 1 1 0 von Willebrand factor type A domain HET PF06985.11 CCF32897.1 - 0.0005 20.4 3.8 0.0038 17.6 0.0 2.4 1 1 1 2 2 2 1 Heterokaryon incompatibility protein (HET) BUD22 PF09073.10 CCF32897.1 - 1.9 7.7 5.6 2.7 7.2 5.6 1.1 1 0 0 1 1 1 0 BUD22 CAF1A PF12253.8 CCF32897.1 - 2.1 8.6 11.7 5.3 7.3 11.7 1.6 1 0 0 1 1 1 0 Chromatin assembly factor 1 subunit A SDA1 PF05285.12 CCF32897.1 - 6 6.2 5.9 8.8 5.6 5.9 1.2 1 0 0 1 1 1 0 SDA1 MFS_1 PF07690.16 CCF32898.1 - 2.1e-40 138.7 28.3 2.1e-40 138.7 28.3 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF32898.1 - 1.9e-11 43.5 2.6 1.9e-11 43.5 2.6 2.0 2 0 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 CCF32898.1 - 0.00065 18.2 2.7 0.00099 17.6 2.7 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF4179 PF13786.6 CCF32898.1 - 0.16 12.5 1.4 94 3.6 0.1 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4179) Zeta_toxin PF06414.12 CCF32900.1 - 5.9e-47 159.5 0.0 8.4e-47 159.0 0.0 1.1 1 0 0 1 1 1 1 Zeta toxin AAA_33 PF13671.6 CCF32900.1 - 5.1e-07 30.0 0.0 9.3e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain TniB PF05621.11 CCF32900.1 - 0.023 14.1 0.0 0.34 10.3 0.0 2.3 2 0 0 2 2 2 0 Bacterial TniB protein AAA_16 PF13191.6 CCF32900.1 - 0.027 14.8 0.3 0.059 13.7 0.0 1.7 2 1 0 2 2 2 0 AAA ATPase domain SRP54 PF00448.22 CCF32900.1 - 0.056 13.1 0.0 0.081 12.5 0.0 1.2 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Sigma54_activat PF00158.26 CCF32900.1 - 0.16 11.6 0.0 0.26 11.0 0.0 1.2 1 0 0 1 1 1 0 Sigma-54 interaction domain LAGLIDADG_3 PF14528.6 CCF32900.1 - 0.16 12.3 0.0 1.9 8.9 0.0 2.2 2 0 0 2 2 2 0 LAGLIDADG-like domain DUF3450 PF11932.8 CCF32900.1 - 0.19 11.0 1.2 0.31 10.3 1.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) RNA_pol_I_A49 PF06870.12 CCF32901.1 - 4e-101 338.7 0.1 4.9e-101 338.4 0.1 1.1 1 0 0 1 1 1 1 A49-like RNA polymerase I associated factor HeH PF12949.7 CCF32902.1 - 7.9e-08 31.9 0.1 1.3e-07 31.1 0.1 1.4 1 0 0 1 1 1 1 HeH/LEM domain CENP-X PF09415.10 CCF32902.1 - 0.12 12.7 0.5 0.21 12.0 0.1 1.6 2 0 0 2 2 2 0 CENP-S associating Centromere protein X ABC_membrane PF00664.23 CCF32903.1 - 1.4e-90 303.7 25.3 1.9e-45 155.7 7.3 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 CCF32903.1 - 4e-51 173.1 0.0 8.4e-31 107.3 0.1 2.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 CCF32903.1 - 7.1e-10 38.7 3.8 0.0044 16.5 0.4 4.2 2 2 0 3 3 3 3 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 CCF32903.1 - 3.1e-06 27.3 0.1 0.13 12.4 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_16 PF13191.6 CCF32903.1 - 0.00039 20.8 0.3 0.068 13.5 0.1 2.6 2 0 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 CCF32903.1 - 0.00056 19.8 0.0 0.69 9.8 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase UPF0093 PF03653.13 CCF32903.1 - 0.00099 19.4 0.3 0.0042 17.3 0.3 2.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0093) AAA_23 PF13476.6 CCF32903.1 - 0.0026 18.3 1.9 0.29 11.6 0.0 3.1 4 0 0 4 4 3 1 AAA domain AAA_29 PF13555.6 CCF32903.1 - 0.0029 17.3 0.2 3.3 7.5 0.0 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.6 CCF32903.1 - 0.0046 16.8 0.1 0.74 9.6 0.0 2.6 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system Dynamin_N PF00350.23 CCF32903.1 - 0.011 15.8 2.6 0.53 10.3 0.0 2.9 3 0 0 3 3 3 0 Dynamin family ABC_membrane_2 PF06472.15 CCF32903.1 - 0.015 14.8 1.7 0.025 14.0 0.1 2.2 2 0 0 2 2 2 0 ABC transporter transmembrane region 2 AAA_15 PF13175.6 CCF32903.1 - 0.018 14.7 0.3 0.76 9.4 0.0 2.4 2 0 0 2 2 2 0 AAA ATPase domain T2SSE PF00437.20 CCF32903.1 - 0.052 12.6 0.1 0.43 9.6 0.1 2.3 2 1 0 2 2 2 0 Type II/IV secretion system protein DUF87 PF01935.17 CCF32903.1 - 0.066 13.3 3.2 1 9.4 0.1 2.7 3 0 0 3 3 2 0 Helicase HerA, central domain IstB_IS21 PF01695.17 CCF32903.1 - 0.068 12.9 0.0 3.1 7.5 0.0 2.6 2 0 0 2 2 2 0 IstB-like ATP binding protein FtsK_SpoIIIE PF01580.18 CCF32903.1 - 0.13 11.6 0.2 15 4.8 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family NACHT PF05729.12 CCF32903.1 - 0.46 10.4 1.6 1.2 9.0 0.1 2.4 2 0 0 2 2 2 0 NACHT domain AAA_22 PF13401.6 CCF32903.1 - 1.1 9.5 3.4 54 4.0 0.4 3.3 2 1 0 2 2 2 0 AAA domain MWFE PF15879.5 CCF32903.1 - 1.7 8.9 5.0 1.3 9.3 0.4 3.0 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase MWFE subunit Ribosomal_L5_C PF00673.21 CCF32905.1 - 1e-24 86.5 0.0 1.6e-24 85.9 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 CCF32905.1 - 1.8e-07 31.4 0.2 3.3e-07 30.5 0.2 1.4 1 0 0 1 1 1 1 Ribosomal protein L5 Fes1 PF08609.10 CCF32906.1 - 6.8e-29 100.6 4.2 9.7e-29 100.1 1.6 2.2 2 0 0 2 2 2 1 Nucleotide exchange factor Fes1 HEAT PF02985.22 CCF32906.1 - 1.2e-05 25.1 0.0 0.012 15.8 0.0 2.8 2 0 0 2 2 2 2 HEAT repeat HEAT_2 PF13646.6 CCF32906.1 - 6.8e-05 23.2 0.1 0.00022 21.6 0.0 1.9 2 0 0 2 2 2 1 HEAT repeats HEAT_EZ PF13513.6 CCF32906.1 - 0.00021 21.7 0.1 0.00071 20.0 0.1 1.9 1 0 0 1 1 1 1 HEAT-like repeat Arm PF00514.23 CCF32906.1 - 0.00056 19.9 0.0 0.053 13.6 0.0 2.6 2 0 0 2 2 2 1 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 CCF32906.1 - 0.026 14.5 0.1 0.28 11.2 0.0 2.2 1 1 1 2 2 2 0 Spinocerebellar ataxia type 10 protein domain polyprenyl_synt PF00348.17 CCF32910.1 - 7.7e-50 169.3 0.0 1.5e-49 168.4 0.0 1.4 1 0 0 1 1 1 1 Polyprenyl synthetase Terpene_synth_C PF03936.16 CCF32910.1 - 7.5e-05 22.2 0.2 0.57 9.5 0.0 3.4 3 1 0 3 3 3 2 Terpene synthase family, metal binding domain ANTAR PF03861.14 CCF32910.1 - 0.02 14.8 0.2 0.25 11.2 0.0 2.5 2 0 0 2 2 2 0 ANTAR domain DUF459 PF04311.13 CCF32910.1 - 0.028 13.4 0.0 0.064 12.2 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF459) p450 PF00067.22 CCF32911.1 - 5.4e-51 173.8 0.0 7.3e-44 150.3 0.0 2.0 1 1 1 2 2 2 2 Cytochrome P450 FACT-Spt16_Nlob PF14826.6 CCF32912.1 - 4.5e-10 39.6 0.0 5.5e-10 39.3 0.0 1.0 1 0 0 1 1 1 1 FACT complex subunit SPT16 N-terminal lobe domain DUF3130 PF11328.8 CCF32912.1 - 0.07 13.4 0.0 0.11 12.8 0.0 1.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3130 CMD PF02627.20 CCF32913.1 - 1.1e-09 38.2 0.1 2.5e-08 33.8 0.0 2.2 2 0 0 2 2 2 1 Carboxymuconolactone decarboxylase family IMD PF08397.11 CCF32914.1 - 0.072 12.5 0.1 0.14 11.6 0.1 1.6 1 1 0 1 1 1 0 IRSp53/MIM homology domain CsbD PF05532.12 CCF32916.1 - 1.4e-17 63.3 18.3 2e-12 46.8 2.0 3.4 2 1 1 3 3 3 2 CsbD-like PDGLE PF13190.6 CCF32916.1 - 0.33 10.9 1.9 3.4 7.6 1.9 2.3 1 1 0 1 1 1 0 PDGLE domain Aminotran_5 PF00266.19 CCF32917.1 - 1.3e-63 215.2 0.0 1.5e-63 215.0 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 CCF32917.1 - 2.8e-05 23.6 0.0 0.00016 21.1 0.0 1.8 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.21 CCF32917.1 - 0.00084 18.7 0.0 0.0012 18.2 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Pyridoxal_deC PF00282.19 CCF32917.1 - 0.0026 16.6 0.0 0.0038 16.0 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain B12-binding PF02310.19 CCF32917.1 - 0.071 13.1 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 B12 binding domain p450 PF00067.22 CCF32918.1 - 5.8e-27 94.5 0.0 7.9e-27 94.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 PIP49_N PF14875.6 CCF32918.1 - 0.11 12.4 0.1 0.19 11.6 0.1 1.3 1 0 0 1 1 1 0 N-term cysteine-rich ER, FAM69 DNA_meth_N PF18284.1 CCF32918.1 - 0.13 12.2 0.1 0.29 11.1 0.1 1.5 1 0 0 1 1 1 0 DNA methylase N-terminal domain ODAPH PF15848.5 CCF32920.1 - 0.19 12.2 5.2 0.24 11.8 0.9 2.4 2 0 0 2 2 2 0 Odontogenesis associated phosphoprotein Acyl_transf_3 PF01757.22 CCF32921.1 - 1.1e-38 133.2 27.7 1.3e-38 132.9 27.7 1.1 1 0 0 1 1 1 1 Acyltransferase family Gly_transf_sug PF04488.15 CCF32922.1 - 4.5e-12 46.4 1.2 1.2e-11 45.1 0.1 2.1 2 0 0 2 2 2 1 Glycosyltransferase sugar-binding region containing DXD motif T2SSM PF04612.12 CCF32922.1 - 4.1 7.4 0.0 4.1 7.4 0.0 2.2 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein M Pec_lyase_C PF00544.19 CCF32923.1 - 5.2e-38 130.7 7.2 5.2e-38 130.7 7.2 1.5 1 1 0 1 1 1 1 Pectate lyase IQ PF00612.27 CCF32926.1 - 1.6e-05 24.3 0.8 4.8e-05 22.8 0.8 1.9 1 0 0 1 1 1 1 IQ calmodulin-binding motif IMUP PF15761.5 CCF32926.1 - 3.1 8.6 18.5 2 9.2 6.8 3.5 3 0 0 3 3 3 0 Immortalisation up-regulated protein SAS4 PF15460.6 CCF32927.1 - 1.6e-31 108.3 1.3 3.1e-31 107.4 0.1 2.1 2 1 1 3 3 3 1 Something about silencing, SAS, complex subunit 4 Adaptin_binding PF10199.9 CCF32927.1 - 0.0023 18.5 5.8 0.0049 17.5 5.3 1.9 1 1 0 1 1 1 1 Alpha and gamma adaptin binding protein p34 DFRP_C PF16543.5 CCF32927.1 - 0.84 10.2 4.8 1.3 9.6 3.3 2.1 1 1 1 2 2 2 0 DRG Family Regulatory Proteins, Tma46 CDC45 PF02724.14 CCF32927.1 - 3.3 5.9 9.8 5 5.3 9.8 1.2 1 0 0 1 1 1 0 CDC45-like protein Peptidase_M1_N PF17900.1 CCF32928.1 - 0.079 13.1 0.0 0.12 12.6 0.0 1.2 1 0 0 1 1 1 0 Peptidase M1 N-terminal domain Aconitase PF00330.20 CCF32930.1 - 4e-149 497.5 0.0 5.1e-149 497.2 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 CCF32930.1 - 2e-43 147.8 0.0 3.6e-43 147.0 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain zf-C2H2_jaz PF12171.8 CCF32932.1 - 1.8e-10 40.8 0.1 3.4e-10 39.9 0.1 1.5 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 CCF32932.1 - 0.0036 17.6 1.5 0.43 10.9 0.2 2.1 1 1 1 2 2 2 2 C2H2 type zinc-finger (2 copies) Spuma_A9PTase PF03539.14 CCF32932.1 - 0.036 14.2 0.2 0.044 13.9 0.2 1.1 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) zf-C2H2_6 PF13912.6 CCF32932.1 - 0.045 13.8 0.2 0.077 13.0 0.2 1.5 1 0 0 1 1 1 0 C2H2-type zinc finger DASH_Dam1 PF08653.10 CCF32933.1 - 3.4e-27 94.0 1.9 4.9e-27 93.5 1.9 1.3 1 0 0 1 1 1 1 DASH complex subunit Dam1 SQHop_cyclase_C PF13243.6 CCF32935.1 - 8.8e-54 182.8 0.0 1.1e-53 182.4 0.0 1.1 1 0 0 1 1 1 1 Squalene-hopene cyclase C-terminal domain Prenyltrans PF00432.21 CCF32935.1 - 2.5e-19 68.7 6.9 1.2e-11 44.1 0.1 4.0 4 0 0 4 4 4 3 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_N PF13249.6 CCF32935.1 - 3.3e-07 29.7 0.2 0.00018 20.7 0.0 3.3 2 1 1 3 3 3 1 Squalene-hopene cyclase N-terminal domain TED_complement PF07678.14 CCF32935.1 - 0.00054 19.1 0.4 0.0097 15.0 0.1 2.7 2 1 1 3 3 3 1 A-macroglobulin TED domain Pec_lyase PF09492.10 CCF32935.1 - 0.0061 15.9 0.0 0.86 8.9 0.0 3.1 1 1 2 3 3 3 1 Pectic acid lyase Cpn60_TCP1 PF00118.24 CCF32936.1 - 0.0019 16.9 0.1 0.0023 16.7 0.1 1.1 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Prenylcys_lyase PF07156.14 CCF32937.1 - 2.5e-108 362.4 0.0 3.3e-108 362.1 0.0 1.0 1 0 0 1 1 1 1 Prenylcysteine lyase NAD_binding_8 PF13450.6 CCF32937.1 - 1.2e-12 47.9 0.0 3.6e-12 46.3 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 CCF32937.1 - 9.4e-11 41.6 0.0 1.3e-10 41.2 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase DAO PF01266.24 CCF32937.1 - 5.2e-06 26.3 0.2 2.5e-05 24.0 0.3 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCF32937.1 - 0.00074 18.8 0.1 0.024 13.9 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CCF32937.1 - 0.0027 17.7 0.1 0.018 15.0 0.0 2.3 2 0 0 2 2 2 1 FAD-NAD(P)-binding VID27 PF08553.10 CCF32938.1 - 2.2e-192 638.8 0.1 2.8e-192 638.5 0.1 1.1 1 0 0 1 1 1 1 VID27 C-terminal WD40-like domain VID27_N PF17748.1 CCF32938.1 - 2.6e-76 255.3 0.5 2.6e-76 255.3 0.5 2.6 2 0 0 2 2 2 1 VID27 N-terminal region VID27_PH PF17747.1 CCF32938.1 - 2.3e-43 146.9 2.4 3.8e-43 146.2 1.5 1.9 2 0 0 2 2 2 1 VID27 PH-like domain DNA_pol_phi PF04931.13 CCF32938.1 - 1.1 7.3 13.5 1.7 6.6 13.5 1.2 1 0 0 1 1 1 0 DNA polymerase phi Herpes_gE PF02480.16 CCF32938.1 - 1.5 7.5 3.5 2.4 6.8 3.5 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E CDC45 PF02724.14 CCF32938.1 - 5.3 5.2 8.8 7.4 4.7 8.8 1.1 1 0 0 1 1 1 0 CDC45-like protein Glyco_transf_20 PF00982.21 CCF32939.1 - 7.5e-32 110.6 0.2 8.9e-32 110.4 0.2 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 20 TPR_14 PF13428.6 CCF32940.1 - 6.4e-06 26.6 6.2 0.094 13.6 0.0 7.1 7 2 2 9 9 9 1 Tetratricopeptide repeat Suf PF05843.14 CCF32940.1 - 0.0014 18.7 13.0 0.11 12.5 0.1 3.7 3 1 0 3 3 3 3 Suppressor of forked protein (Suf) HTS PF04204.16 CCF32940.1 - 3.8 6.3 10.2 0.64 8.9 3.4 2.1 2 0 0 2 2 2 0 Homoserine O-succinyltransferase Biotin_lipoyl PF00364.22 CCF32942.1 - 1.5e-18 66.4 0.8 3e-18 65.4 0.8 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 CCF32942.1 - 8.7e-07 29.2 0.1 8.7e-07 29.2 0.1 2.1 2 0 0 2 2 2 1 e3 binding domain Biotin_lipoyl_2 PF13533.6 CCF32942.1 - 0.00051 19.8 0.0 0.0045 16.8 0.0 2.3 2 0 0 2 2 2 1 Biotin-lipoyl like HlyD_3 PF13437.6 CCF32942.1 - 0.0087 16.7 0.2 0.21 12.3 0.0 2.9 2 1 1 3 3 3 1 HlyD family secretion protein Methyltransf_23 PF13489.6 CCF32943.1 - 1.8e-21 76.7 0.0 2.6e-21 76.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF32943.1 - 9.6e-13 48.7 0.0 8e-12 45.7 0.0 2.4 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF32943.1 - 7.1e-10 38.9 0.0 0.00022 21.0 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 CCF32943.1 - 1e-09 38.9 0.0 3.5e-09 37.2 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF32943.1 - 5e-06 27.2 0.0 6.4e-05 23.6 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CCF32943.1 - 0.004 16.7 0.0 0.0076 15.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 CCF32943.1 - 0.0084 15.5 0.0 0.015 14.7 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Ubie_methyltran PF01209.18 CCF32943.1 - 0.015 14.6 0.0 0.67 9.3 0.0 2.1 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 CCF32943.1 - 0.12 11.8 0.0 0.26 10.7 0.0 1.5 1 0 0 1 1 1 0 Putative methyltransferase CoA_transf_3 PF02515.17 CCF32944.1 - 6.6e-39 134.1 0.2 7.9e-36 123.9 0.0 2.2 2 0 0 2 2 2 2 CoA-transferase family III A1_Propeptide PF07966.12 CCF32945.1 - 0.018 14.9 1.2 0.048 13.5 0.3 2.0 2 0 0 2 2 2 0 A1 Propeptide Put_Phosphatase PF06888.12 CCF32947.1 - 0.038 13.4 0.0 0.04 13.3 0.0 1.0 1 0 0 1 1 1 0 Putative Phosphatase Cnl2_NKP2 PF09447.10 CCF32947.1 - 0.095 12.9 0.2 0.15 12.2 0.2 1.4 1 1 0 1 1 1 0 Cnl2/NKP2 family protein Aminotran_4 PF01063.19 CCF32949.1 - 4e-20 72.6 0.0 7e-20 71.8 0.0 1.3 1 0 0 1 1 1 1 Amino-transferase class IV Asp PF00026.23 CCF32950.1 - 3.3e-65 220.6 0.1 3.9e-65 220.3 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCF32950.1 - 1.8e-14 54.4 2.0 9.1e-10 39.1 0.0 3.0 2 1 1 3 3 3 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 CCF32950.1 - 6.5e-05 23.5 0.4 0.63 10.7 0.0 2.7 2 1 0 2 2 2 2 Aspartyl protease Btz PF09405.10 CCF32951.1 - 1.3e-27 96.6 2.4 3.1e-27 95.4 2.4 1.6 1 0 0 1 1 1 1 CASC3/Barentsz eIF4AIII binding GNAT_acetyltr_2 PF13718.6 CCF32952.1 - 5.4e-96 320.4 0.0 1.2e-95 319.2 0.0 1.6 1 0 0 1 1 1 1 GNAT acetyltransferase 2 tRNA_bind_2 PF13725.6 CCF32952.1 - 7.9e-94 313.8 0.0 1.4e-93 312.9 0.0 1.5 1 0 0 1 1 1 1 Possible tRNA binding domain Helicase_RecD PF05127.14 CCF32952.1 - 1.1e-65 220.8 0.1 4e-65 219.0 0.0 2.0 2 0 0 2 2 2 1 Helicase DUF1726 PF08351.11 CCF32952.1 - 4.5e-34 116.2 0.0 1.3e-33 114.8 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1726) AAA_30 PF13604.6 CCF32952.1 - 0.00011 21.9 0.5 0.0067 16.2 0.1 2.6 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 CCF32952.1 - 0.0013 19.0 0.0 0.072 13.4 0.0 2.9 2 0 0 2 2 2 1 AAA domain GHMP_kinases_N PF00288.26 CCF32952.1 - 0.072 13.3 0.1 0.18 12.0 0.1 1.7 1 0 0 1 1 1 0 GHMP kinases N terminal domain DUF1713 PF08213.11 CCF32953.1 - 2.5e-10 40.1 22.0 2.5e-10 40.1 22.0 2.0 2 0 0 2 2 2 1 Mitochondrial domain of unknown function (DUF1713) Pet20 PF08692.10 CCF32953.1 - 0.0017 19.1 0.0 0.0017 19.1 0.0 2.1 3 0 0 3 3 3 1 Mitochondrial protein Pet20 PhyH PF05721.13 CCF32954.1 - 3.7e-09 37.1 0.0 3.3e-08 34.0 0.0 2.3 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) NLPC_P60 PF00877.19 CCF32954.1 - 0.013 15.5 0.0 0.022 14.8 0.0 1.3 1 0 0 1 1 1 0 NlpC/P60 family 2OG-FeII_Oxy_3 PF13640.6 CCF32954.1 - 0.044 14.7 0.0 0.091 13.7 0.0 1.5 1 1 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Mpv17_PMP22 PF04117.12 CCF32955.1 - 2.5e-23 82.0 0.2 4.4e-23 81.3 0.2 1.4 1 0 0 1 1 1 1 Mpv17 / PMP22 family HATPase_c PF02518.26 CCF32956.1 - 2.4e-28 98.9 0.2 4.6e-28 98.0 0.2 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CCF32956.1 - 4.3e-22 78.4 0.2 9.6e-22 77.3 0.2 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 CCF32956.1 - 9.5e-22 76.8 0.5 2.7e-21 75.4 0.1 2.1 2 0 0 2 2 1 1 His Kinase A (phospho-acceptor) domain PAS_3 PF08447.12 CCF32956.1 - 2.8e-18 66.0 0.2 1.2e-17 63.9 0.1 2.2 2 0 0 2 2 2 1 PAS fold PAS_4 PF08448.10 CCF32956.1 - 1e-09 38.6 0.1 1.1e-05 25.7 0.0 3.7 3 2 0 3 3 3 2 PAS fold PAS_9 PF13426.7 CCF32956.1 - 1.4e-09 38.1 0.0 2.7e-06 27.6 0.0 3.5 3 0 0 3 3 3 1 PAS domain PAS PF00989.25 CCF32956.1 - 0.00033 20.6 0.0 0.059 13.4 0.0 2.9 2 0 0 2 2 2 1 PAS fold HATPase_c_3 PF13589.6 CCF32956.1 - 0.014 15.2 0.0 0.032 14.1 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_11 PF14598.6 CCF32956.1 - 0.017 15.2 0.0 0.041 14.0 0.0 1.6 1 0 0 1 1 1 0 PAS domain Phage_GP20 PF06810.11 CCF32956.1 - 0.035 13.9 0.7 0.092 12.5 0.7 1.7 1 0 0 1 1 1 0 Phage minor structural protein GP20 GRIP PF01465.20 CCF32956.1 - 0.16 11.9 0.1 1.4 8.9 0.0 2.4 2 0 0 2 2 2 0 GRIP domain LPP PF04728.13 CCF32956.1 - 0.29 11.6 2.7 0.78 10.2 2.7 1.7 1 0 0 1 1 1 0 Lipoprotein leucine-zipper ABC_membrane PF00664.23 CCF32957.1 - 3.2e-55 187.7 19.7 4.6e-33 115.0 3.9 3.4 3 0 0 3 3 3 2 ABC transporter transmembrane region ABC_tran PF00005.27 CCF32957.1 - 2.4e-49 167.3 1.7 1.1e-29 103.6 0.0 3.1 3 0 0 3 3 2 2 ABC transporter SMC_N PF02463.19 CCF32957.1 - 1.3e-08 34.5 1.5 0.012 15.1 0.1 4.1 3 1 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CCF32957.1 - 4.9e-05 23.0 0.2 0.43 10.3 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 CCF32957.1 - 7e-05 23.4 25.6 0.00079 20.0 0.0 3.9 4 0 0 4 4 2 2 AAA domain T2SSE PF00437.20 CCF32957.1 - 0.00018 20.7 0.0 0.015 14.4 0.1 2.6 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_15 PF13175.6 CCF32957.1 - 0.00044 20.1 0.0 1 9.0 0.0 3.2 2 1 0 2 2 2 2 AAA ATPase domain MMR_HSR1 PF01926.23 CCF32957.1 - 0.00051 20.1 0.0 0.11 12.5 0.0 2.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_21 PF13304.6 CCF32957.1 - 0.0013 18.6 1.5 14 5.4 0.0 3.5 3 0 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 CCF32957.1 - 0.0027 17.6 0.0 2.2 8.1 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 CCF32957.1 - 0.0028 17.9 0.0 11 6.2 0.0 3.4 3 0 0 3 3 3 0 AAA domain IstB_IS21 PF01695.17 CCF32957.1 - 0.0047 16.7 0.2 0.34 10.6 0.0 2.7 3 0 0 3 3 2 1 IstB-like ATP binding protein AAA_16 PF13191.6 CCF32957.1 - 0.0059 17.0 4.9 0.9 9.9 0.0 3.2 3 0 0 3 3 2 2 AAA ATPase domain AAA PF00004.29 CCF32957.1 - 0.017 15.5 0.3 10 6.5 0.0 3.5 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) Borrelia_P83 PF05262.11 CCF32957.1 - 0.028 12.9 27.4 0.068 11.6 27.4 1.6 1 0 0 1 1 1 0 Borrelia P83/100 protein AAA_25 PF13481.6 CCF32957.1 - 0.03 13.9 0.0 1.6 8.3 0.0 2.5 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.17 CCF32957.1 - 0.036 14.1 0.0 0.036 14.1 0.0 3.8 4 0 0 4 4 3 0 Helicase HerA, central domain AAA_7 PF12775.7 CCF32957.1 - 0.12 11.9 0.0 18 4.8 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region DEAD PF00270.29 CCF32957.1 - 0.16 11.7 0.1 15 5.3 0.0 3.2 3 0 0 3 3 3 0 DEAD/DEAH box helicase cobW PF02492.19 CCF32957.1 - 0.27 10.8 1.6 1.8 8.1 0.3 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain DUF4192 PF13830.6 CCF32957.1 - 0.28 11.2 8.5 0.54 10.3 8.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4192) ResIII PF04851.15 CCF32957.1 - 0.45 10.5 3.9 11 6.0 0.1 3.3 4 0 0 4 4 2 0 Type III restriction enzyme, res subunit CbiA PF01656.23 CCF32957.1 - 2.1 8.4 6.1 2.1 8.4 0.0 3.4 4 0 0 4 4 3 0 CobQ/CobB/MinD/ParA nucleotide binding domain SAPS PF04499.15 CCF32957.1 - 2.9 6.6 9.7 5.5 5.7 9.7 1.4 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein AAA_12 PF13087.6 CCF32958.1 - 4.5e-14 52.6 0.1 5.9e-14 52.2 0.1 1.2 1 0 0 1 1 1 1 AAA domain zf-CCHC PF00098.23 CCF32958.1 - 0.034 14.2 15.4 0.11 12.6 2.0 2.9 3 0 0 3 3 3 0 Zinc knuckle UvrD_C_2 PF13538.6 CCF32958.1 - 0.064 13.1 0.0 0.21 11.4 0.0 1.9 2 0 0 2 2 2 0 UvrD-like helicase C-terminal domain zf-CCHC_4 PF14392.6 CCF32958.1 - 3.3 7.5 10.6 2.7 7.8 1.6 2.9 2 1 1 3 3 3 0 Zinc knuckle MFS_1 PF07690.16 CCF32959.1 - 9.2e-26 90.6 18.3 1.4e-25 90.0 18.3 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_1 PF07690.16 CCF32960.1 - 4.5e-43 147.5 39.1 4.5e-43 147.5 39.1 1.9 2 1 0 2 2 2 1 Major Facilitator Superfamily Fungal_trans PF04082.18 CCF32962.1 - 0.0022 17.1 0.6 0.025 13.6 0.6 2.2 1 1 0 1 1 1 1 Fungal specific transcription factor domain Ldh_1_C PF02866.18 CCF32963.1 - 6.2e-44 149.9 0.0 8.6e-44 149.4 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 CCF32963.1 - 3.2e-43 147.2 0.0 4.4e-43 146.7 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 CCF32963.1 - 8e-06 25.1 0.0 1.3e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Semialdhyde_dh PF01118.24 CCF32963.1 - 0.018 15.5 0.1 0.11 12.9 0.0 2.1 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain NAD_binding_10 PF13460.6 CCF32963.1 - 0.056 13.3 0.0 0.12 12.3 0.0 1.7 1 0 0 1 1 1 0 NAD(P)H-binding Iso_dh PF00180.20 CCF32964.1 - 4.8e-86 289.0 0.0 5.8e-86 288.8 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase DUF3123 PF11321.8 CCF32965.1 - 0.0098 16.6 2.8 0.011 16.4 1.5 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF3123) Ribosomal_60s PF00428.19 CCF32965.1 - 0.16 12.5 0.9 0.29 11.7 0.9 1.3 1 0 0 1 1 1 0 60s Acidic ribosomal protein Cyclin_N PF00134.23 CCF32967.1 - 2.6e-08 33.6 0.1 4e-08 33.0 0.1 1.2 1 0 0 1 1 1 1 Cyclin, N-terminal domain Zona_pellucida PF00100.23 CCF32967.1 - 0.07 12.9 0.6 0.65 9.7 0.1 2.0 1 1 0 2 2 2 0 Zona pellucida-like domain Palm_thioest PF02089.15 CCF32968.1 - 1.7e-80 270.4 0.0 2e-80 270.1 0.0 1.1 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Lipase_2 PF01674.18 CCF32968.1 - 0.0019 17.8 0.0 0.041 13.4 0.0 2.1 1 1 0 1 1 1 1 Lipase (class 2) DUF915 PF06028.11 CCF32968.1 - 0.003 16.9 0.1 0.064 12.6 0.0 2.1 2 0 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF915) Abhydrolase_2 PF02230.16 CCF32968.1 - 0.21 11.4 0.2 15 5.3 0.0 2.3 1 1 1 2 2 2 0 Phospholipase/Carboxylesterase Ribosomal_L1 PF00687.21 CCF32969.1 - 7e-69 231.7 1.8 7e-69 231.7 1.8 2.1 2 1 0 2 2 2 1 Ribosomal protein L1p/L10e family DPBB_1 PF03330.18 CCF32970.1 - 0.0036 17.5 0.0 0.0065 16.7 0.0 1.6 1 0 0 1 1 1 1 Lytic transglycolase DAO PF01266.24 CCF32971.1 - 6.3e-39 134.5 4.5 8.6e-39 134.1 4.5 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CCF32971.1 - 0.00043 20.4 0.3 0.0012 19.0 0.0 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CCF32971.1 - 0.086 12.1 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase eIF-5_eIF-2B PF01873.17 CCF32972.1 - 1.5e-41 141.0 0.7 2.4e-41 140.3 0.7 1.3 1 0 0 1 1 1 1 Domain found in IF2B/IF5 SLX9 PF15341.6 CCF32972.1 - 0.026 14.9 0.8 0.046 14.1 0.8 1.4 1 0 0 1 1 1 0 Ribosome biogenesis protein SLX9 PilX PF13681.6 CCF32972.1 - 0.13 12.7 0.1 0.6 10.5 0.0 2.1 2 0 0 2 2 2 0 Type IV pilus assembly protein PilX C-term Arc_trans_TRASH PF08394.10 CCF32972.1 - 0.76 10.2 7.0 1.7 9.0 0.2 2.4 1 1 1 2 2 2 0 Archaeal TRASH domain Glyco_hydro_47 PF01532.20 CCF32974.1 - 6e-170 566.1 0.0 7.8e-170 565.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Autophagy_act_C PF03987.15 CCF32975.1 - 1.9e-12 47.6 0.0 4e-12 46.5 0.0 1.6 1 1 0 1 1 1 1 Autophagocytosis associated protein, active-site domain RRM_1 PF00076.22 CCF32976.1 - 1.7e-09 37.4 0.0 4.5e-09 36.0 0.0 1.7 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CCF32976.1 - 7.3e-06 25.6 0.0 1.1e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 CCF32976.1 - 0.0025 17.9 0.2 0.0057 16.7 0.0 1.6 2 0 0 2 2 2 1 Limkain b1 Calcipressin PF04847.12 CCF32976.1 - 0.011 15.5 0.0 0.02 14.7 0.0 1.4 1 0 0 1 1 1 0 Calcipressin RRM_occluded PF16842.5 CCF32976.1 - 0.16 11.8 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 Occluded RNA-recognition motif WD40 PF00400.32 CCF32977.1 - 3.4e-18 65.6 9.7 0.00023 21.9 0.0 6.9 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF32977.1 - 4e-07 30.2 0.0 0.02 15.2 0.0 4.0 4 1 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 CCF32977.1 - 0.008 16.1 0.0 5.4 7.1 0.0 3.0 2 0 0 2 2 2 2 WD40-like Beta Propeller Repeat MFS_1 PF07690.16 CCF32978.1 - 2.8e-36 125.2 34.2 3e-35 121.8 29.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF32978.1 - 6.1e-15 55.0 9.3 6.1e-15 55.0 9.3 3.0 2 1 0 2 2 2 1 Sugar (and other) transporter Fzo_mitofusin PF04799.13 CCF32978.1 - 0.19 11.3 0.1 0.35 10.4 0.1 1.3 1 0 0 1 1 1 0 fzo-like conserved region adh_short_C2 PF13561.6 CCF32979.1 - 4.3e-07 29.7 0.0 5e-07 29.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Methyltrn_RNA_3 PF02598.17 CCF32981.1 - 1.2e-101 340.1 0.0 1.3e-101 339.9 0.0 1.0 1 0 0 1 1 1 1 Putative RNA methyltransferase SpoU_methylase PF00588.19 CCF32981.1 - 0.029 14.5 0.0 8.6 6.5 0.0 2.3 2 0 0 2 2 2 0 SpoU rRNA Methylase family Thioredoxin PF00085.20 CCF32982.1 - 3e-26 91.4 0.0 4.2e-26 90.9 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 CCF32982.1 - 3.8e-06 27.3 0.1 8.6e-06 26.2 0.1 1.5 1 1 0 1 1 1 1 Thioredoxin-like domain OST3_OST6 PF04756.13 CCF32982.1 - 9.3e-06 25.2 0.0 1.1e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 CCF32982.1 - 0.00014 22.1 0.0 0.00056 20.2 0.0 1.8 1 1 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.21 CCF32982.1 - 0.00092 19.1 0.0 0.0016 18.3 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_9 PF14595.6 CCF32982.1 - 0.0021 17.8 0.0 0.0029 17.4 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin SelK_SelG PF10961.8 CCF32982.1 - 0.0024 18.4 0.0 0.0054 17.3 0.0 1.6 1 1 0 1 1 1 1 Selenoprotein SelK_SelG Thioredoxin_7 PF13899.6 CCF32982.1 - 0.015 15.4 0.0 0.025 14.8 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin-like Redoxin PF08534.10 CCF32982.1 - 0.033 13.9 0.0 0.051 13.3 0.0 1.4 1 0 0 1 1 1 0 Redoxin HyaE PF07449.11 CCF32982.1 - 0.041 13.9 0.0 0.12 12.3 0.0 1.7 2 0 0 2 2 2 0 Hydrogenase-1 expression protein HyaE Rsm22 PF09243.10 CCF32983.1 - 3.9e-31 108.3 0.0 9.2e-31 107.1 0.0 1.6 1 1 0 1 1 1 1 Mitochondrial small ribosomal subunit Rsm22 Methyltransf_23 PF13489.6 CCF32983.1 - 0.0015 18.4 0.0 0.0038 17.1 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF32983.1 - 0.012 16.2 0.0 0.034 14.8 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.12 CCF32983.1 - 0.018 15.7 0.0 0.049 14.3 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 CCF32983.1 - 0.044 13.6 0.0 0.1 12.4 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 CCF32983.1 - 0.095 13.5 0.5 0.23 12.2 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain BROMI PF14961.6 CCF32983.1 - 0.34 8.3 1.7 0.49 7.7 1.7 1.1 1 0 0 1 1 1 0 Broad-minded protein NAD_binding_7 PF13241.6 CCF32984.1 - 4.6e-08 33.5 0.0 5.3e-08 33.2 0.0 1.1 1 0 0 1 1 1 1 Putative NAD(P)-binding DUF998 PF06197.13 CCF32985.1 - 0.045 13.4 0.6 0.045 13.4 0.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF998) HNH PF01844.23 CCF32986.1 - 0.0011 19.1 1.8 0.002 18.3 1.8 1.4 1 0 0 1 1 1 1 HNH endonuclease Hydrolase PF00702.26 CCF32987.1 - 0.00038 20.8 0.1 0.0017 18.7 0.1 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 CCF32987.1 - 0.0035 17.4 0.0 0.017 15.2 0.0 2.0 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CCF32987.1 - 0.0041 17.2 0.0 0.0066 16.5 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like ThiJ_like PF17124.5 CCF32988.1 - 4.5e-39 134.2 0.0 5.6e-39 133.9 0.0 1.1 1 0 0 1 1 1 1 ThiJ/PfpI family-like DJ-1_PfpI PF01965.24 CCF32988.1 - 3.1e-06 27.1 0.0 7.6e-06 25.8 0.0 1.6 2 0 0 2 2 2 1 DJ-1/PfpI family S-methyl_trans PF02574.16 CCF32990.1 - 1e-56 192.7 0.0 1.2e-56 192.5 0.0 1.0 1 0 0 1 1 1 1 Homocysteine S-methyltransferase E1-E2_ATPase PF00122.20 CCF32993.1 - 1e-40 139.2 2.3 4.1e-39 134.0 0.1 2.6 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 CCF32993.1 - 6.1e-35 120.6 5.2 6.1e-35 120.6 5.2 2.9 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 CCF32993.1 - 1.5e-15 58.1 0.0 5.2e-08 33.4 0.0 3.3 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CCF32993.1 - 1.7e-11 44.0 0.0 3.6e-11 43.0 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 CCF32993.1 - 1.6e-09 37.3 0.0 4.4e-09 35.9 0.0 1.8 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus DUF2157 PF09925.9 CCF32993.1 - 7.1e-05 22.6 4.4 0.00021 21.1 0.0 3.0 3 0 0 3 3 3 1 Predicted membrane protein (DUF2157) Hydrolase_3 PF08282.12 CCF32993.1 - 0.0038 17.0 0.2 0.011 15.5 0.2 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Kinesin_assoc PF16183.5 CCF32993.1 - 0.17 12.0 0.4 0.41 10.8 0.0 1.8 2 0 0 2 2 2 0 Kinesin-associated DUF2231 PF09990.9 CCF32993.1 - 0.56 10.7 5.9 0.08 13.4 0.7 2.4 2 0 0 2 2 2 0 Predicted membrane protein (DUF2231) DUF3262 PF11660.8 CCF32993.1 - 2 8.8 7.8 5.6 7.4 0.3 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3262) Sugar_tr PF00083.24 CCF32994.1 - 8.8e-17 61.1 2.5 1e-16 60.9 2.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF32994.1 - 0.00015 20.8 5.1 0.00015 20.8 5.1 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF3684 PF12449.8 CCF32996.1 - 0 1500.4 0.0 0 1500.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3684) HATPase_c_3 PF13589.6 CCF32996.1 - 0.0001 22.1 0.0 0.0004 20.2 0.0 2.1 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase ANKH PF07260.11 CCF32997.1 - 0.015 14.6 0.0 0.019 14.2 0.0 1.1 1 0 0 1 1 1 0 Progressive ankylosis protein (ANKH) DUF3433 PF11915.8 CCF32998.1 - 2.9e-31 107.8 8.5 2.9e-17 62.9 2.2 5.0 5 0 0 5 5 5 2 Protein of unknown function (DUF3433) Spt20 PF12090.8 CCF32998.1 - 0.0023 17.6 13.4 0.0023 17.6 13.4 3.4 2 1 0 3 3 3 1 Spt20 family CDC45 PF02724.14 CCF32998.1 - 0.052 11.8 3.3 0.12 10.6 3.3 1.5 1 0 0 1 1 1 0 CDC45-like protein PBP1_TM PF14812.6 CCF32998.1 - 0.16 12.4 1.9 1.9 8.9 0.2 3.0 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Ctr PF04145.15 CCF32999.1 - 3.8e-26 92.5 0.0 5e-26 92.1 0.0 1.2 1 0 0 1 1 1 1 Ctr copper transporter family Sortilin-Vps10 PF15902.5 CCF33000.1 - 3.1e-07 29.5 0.0 2.4e-05 23.3 0.0 2.2 1 1 1 2 2 2 2 Sortilin, neurotensin receptor 3, BNR PF02012.20 CCF33000.1 - 0.00074 19.1 3.6 0.64 10.2 0.1 3.6 2 0 0 2 2 2 2 BNR/Asp-box repeat BNR_2 PF13088.6 CCF33000.1 - 0.015 14.6 0.9 0.11 11.7 0.3 2.4 1 1 2 3 3 3 0 BNR repeat-like domain DUF4185 PF13810.6 CCF33000.1 - 0.031 13.5 2.1 0.054 12.7 0.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4185) Thioredox_DsbH PF03190.15 CCF33000.1 - 0.047 13.7 0.1 0.073 13.0 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF255 BNR_6 PF15899.5 CCF33000.1 - 0.76 10.0 5.2 5.4 7.4 0.0 3.5 4 0 0 4 4 4 0 BNR-Asp box repeat Dynamitin PF04912.14 CCF33001.1 - 0.00016 21.1 2.3 0.00016 21.1 2.3 1.1 1 0 0 1 1 1 1 Dynamitin HAUS-augmin3 PF14932.6 CCF33001.1 - 0.013 15.1 2.7 0.013 15.1 2.7 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 Macoilin PF09726.9 CCF33001.1 - 0.017 13.7 3.5 0.018 13.6 3.5 1.1 1 0 0 1 1 1 0 Macoilin family NBP1 PF08537.10 CCF33001.1 - 0.02 14.3 6.7 0.025 14.0 6.7 1.2 1 0 0 1 1 1 0 Fungal Nap binding protein NBP1 ABC_tran_Xtn PF12848.7 CCF33001.1 - 0.05 13.6 4.8 0.081 13.0 4.8 1.3 1 0 0 1 1 1 0 ABC transporter Tho2 PF11262.8 CCF33001.1 - 0.45 9.7 5.3 0.51 9.5 5.3 1.1 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 V_ATPase_I PF01496.19 CCF33001.1 - 0.91 7.4 3.3 0.86 7.4 3.3 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4337 PF14235.6 CCF33001.1 - 0.93 9.6 6.8 1.3 9.2 6.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) DUF4407 PF14362.6 CCF33001.1 - 2.8 7.2 8.7 3.1 7.1 8.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) HEAT_2 PF13646.6 CCF33002.1 - 4.3e-17 62.3 2.8 5.3e-09 36.4 0.2 2.2 1 1 1 2 2 2 2 HEAT repeats NACHT PF05729.12 CCF33002.1 - 8.7e-14 51.8 0.0 2.7e-13 50.2 0.0 1.9 1 0 0 1 1 1 1 NACHT domain NLRC4_HD2 PF17776.1 CCF33002.1 - 2.4e-07 31.3 2.3 1.7e-05 25.4 0.1 3.3 3 0 0 3 3 3 1 NLRC4 helical domain HD2 HEAT PF02985.22 CCF33002.1 - 5.3e-07 29.3 0.1 0.06 13.6 0.1 2.8 2 0 0 2 2 2 2 HEAT repeat NB-ARC PF00931.22 CCF33002.1 - 4.9e-05 22.6 0.0 0.00011 21.5 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain AAA_16 PF13191.6 CCF33002.1 - 0.00029 21.3 0.0 0.0018 18.7 0.0 2.3 1 1 0 1 1 1 1 AAA ATPase domain HEAT_EZ PF13513.6 CCF33002.1 - 0.00072 20.0 0.1 0.46 11.0 0.1 2.7 2 0 0 2 2 2 1 HEAT-like repeat AAA_22 PF13401.6 CCF33002.1 - 0.0023 18.2 0.1 0.046 14.0 0.0 2.7 2 0 0 2 2 2 1 AAA domain NTPase_1 PF03266.15 CCF33002.1 - 0.016 15.1 0.0 0.04 13.8 0.0 1.6 1 0 0 1 1 1 0 NTPase AAA PF00004.29 CCF33002.1 - 0.028 14.8 0.0 0.12 12.8 0.0 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Vac14_Fab1_bd PF12755.7 CCF33002.1 - 0.035 14.7 0.0 0.097 13.3 0.0 1.8 1 0 0 1 1 1 0 Vacuolar 14 Fab1-binding region BChl_A PF02327.17 CCF33002.1 - 0.062 12.1 0.0 0.1 11.4 0.0 1.2 1 0 0 1 1 1 0 Bacteriochlorophyll A protein AAA_18 PF13238.6 CCF33002.1 - 0.064 13.8 0.0 0.2 12.2 0.0 2.0 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 CCF33002.1 - 0.084 12.6 0.3 0.48 10.1 0.0 2.3 3 0 0 3 3 2 0 AAA domain TsaE PF02367.17 CCF33002.1 - 0.091 12.8 0.0 0.26 11.3 0.0 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE HEAT_PBS PF03130.16 CCF33002.1 - 0.14 12.9 0.0 23 6.0 0.0 2.9 2 0 0 2 2 2 0 PBS lyase HEAT-like repeat PduV-EutP PF10662.9 CCF33002.1 - 0.19 11.5 0.0 0.42 10.4 0.0 1.6 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation NACHT PF05729.12 CCF33003.1 - 5.2e-18 65.5 0.0 8.3e-18 64.8 0.0 1.3 1 0 0 1 1 1 1 NACHT domain NB-ARC PF00931.22 CCF33003.1 - 2e-07 30.5 0.0 4.6e-07 29.3 0.0 1.5 1 1 0 1 1 1 1 NB-ARC domain AAA_22 PF13401.6 CCF33003.1 - 3.2e-06 27.5 0.8 4.1e-05 23.9 0.8 2.1 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CCF33003.1 - 0.00038 20.9 0.1 0.045 14.1 0.0 2.6 3 0 0 3 3 3 1 AAA ATPase domain AAA_18 PF13238.6 CCF33003.1 - 0.00049 20.6 0.3 0.0017 18.9 0.1 2.0 2 1 0 2 2 2 1 AAA domain AAA_14 PF13173.6 CCF33003.1 - 0.0013 18.7 0.4 0.0044 17.1 0.4 1.8 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 CCF33003.1 - 0.0089 15.8 0.0 0.67 9.7 0.0 2.2 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_17 PF13207.6 CCF33003.1 - 0.0099 16.3 0.0 0.074 13.5 0.0 2.4 1 1 0 1 1 1 1 AAA domain NTPase_1 PF03266.15 CCF33003.1 - 0.013 15.4 0.2 0.025 14.5 0.2 1.5 1 0 0 1 1 1 0 NTPase AAA PF00004.29 CCF33003.1 - 0.017 15.6 0.0 0.036 14.5 0.0 1.5 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 CCF33003.1 - 0.019 14.7 0.1 0.037 13.7 0.1 1.5 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CCF33003.1 - 0.022 15.3 0.0 0.037 14.5 0.0 1.4 1 0 0 1 1 1 0 ABC transporter DAP3 PF10236.9 CCF33003.1 - 0.042 13.0 0.0 2.2 7.3 0.0 2.1 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 ResIII PF04851.15 CCF33003.1 - 0.05 13.6 0.0 9.8 6.1 0.0 2.3 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit RNA_helicase PF00910.22 CCF33003.1 - 0.063 13.7 0.0 0.18 12.2 0.0 1.7 2 0 0 2 2 2 0 RNA helicase DNA_alkylation PF08713.11 CCF33003.1 - 0.079 12.7 0.1 0.22 11.2 0.0 1.7 2 0 0 2 2 2 0 DNA alkylation repair enzyme AAA_25 PF13481.6 CCF33003.1 - 0.09 12.3 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 CCF33003.1 - 0.1 12.4 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation TsaE PF02367.17 CCF33003.1 - 0.11 12.5 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RTP1_C2 PF10304.9 CCF33003.1 - 0.11 12.2 0.1 0.2 11.4 0.1 1.5 1 0 0 1 1 1 0 Required for nuclear transport of RNA pol II C-terminus 2 AAA_28 PF13521.6 CCF33003.1 - 0.11 12.7 0.0 5.6 7.2 0.0 2.5 3 0 0 3 3 2 0 AAA domain Sigma54_activat PF00158.26 CCF33003.1 - 0.15 11.8 0.0 1.5 8.5 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain Nucleos_tra2_N PF01773.20 CCF33004.1 - 8.7e-15 55.1 0.2 2.1e-14 53.8 0.2 1.7 1 0 0 1 1 1 1 Na+ dependent nucleoside transporter N-terminus Sugar_tr PF00083.24 CCF33005.1 - 4.8e-69 233.4 26.7 5.6e-69 233.2 26.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF33005.1 - 2.4e-21 76.0 34.4 7.1e-20 71.2 32.0 2.7 2 1 0 3 3 3 2 Major Facilitator Superfamily MFS_2 PF13347.6 CCF33005.1 - 4e-06 25.7 1.7 4e-06 25.7 1.7 3.8 4 1 1 5 5 5 2 MFS/sugar transport protein Pkinase PF00069.25 CCF33006.1 - 8.5e-13 48.3 0.0 3.9e-12 46.1 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF33006.1 - 1.5e-09 37.5 0.0 2.1e-08 33.8 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CCF33007.1 - 0.00019 20.9 0.0 0.00032 20.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain BSP_II PF05432.11 CCF33011.1 - 0.0013 18.5 8.3 0.0016 18.2 8.3 1.1 1 0 0 1 1 1 1 Bone sialoprotein II (BSP-II) Methyltransf_23 PF13489.6 CCF33014.1 - 7.7e-12 45.3 0.0 1.9e-11 44.0 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF33014.1 - 0.00012 22.7 0.0 0.072 13.8 0.0 2.4 1 1 1 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 CCF33014.1 - 0.00015 22.4 0.0 0.042 14.6 0.0 2.4 1 1 1 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.6 CCF33014.1 - 0.0053 16.6 0.0 0.24 11.2 0.0 2.2 1 1 1 2 2 2 1 Methyltransferase domain MTS PF05175.14 CCF33014.1 - 0.0054 16.3 0.0 0.026 14.1 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_11 PF08241.12 CCF33014.1 - 0.012 16.2 0.0 0.6 10.8 0.0 2.4 1 1 0 2 2 2 0 Methyltransferase domain GH131_N PF18271.1 CCF33015.1 - 1e-32 113.9 0.0 1.2e-32 113.6 0.0 1.0 1 0 0 1 1 1 1 Glycoside hydrolase 131 catalytic N-terminal domain DUF3445 PF11927.8 CCF33016.1 - 1.7e-75 253.5 0.0 2e-75 253.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3445) Amidohydro_3 PF07969.11 CCF33017.1 - 1.7e-16 60.8 0.9 1e-10 41.8 0.0 3.2 3 0 0 3 3 3 3 Amidohydrolase family Amidohydro_1 PF01979.20 CCF33017.1 - 3.6e-12 46.3 0.0 3.5e-10 39.7 0.0 3.3 3 1 0 3 3 3 1 Amidohydrolase family NCA2 PF08637.10 CCF33019.1 - 1.9e-109 365.3 0.0 2.8e-109 364.8 0.0 1.2 1 0 0 1 1 1 1 ATP synthase regulation protein NCA2 TMEM171 PF15471.6 CCF33019.1 - 0.23 10.4 0.1 0.37 9.7 0.1 1.2 1 0 0 1 1 1 0 Transmembrane protein family 171 Ras PF00071.22 CCF33020.1 - 2.6e-64 215.7 0.0 3e-64 215.5 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCF33020.1 - 7.5e-34 116.5 0.0 1.3e-33 115.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCF33020.1 - 4.2e-13 49.1 0.0 4.7e-13 49.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 CCF33020.1 - 1.1e-05 25.1 0.0 2.3e-05 24.1 0.0 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 CCF33020.1 - 0.00028 20.3 0.0 0.0003 20.2 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 CCF33020.1 - 0.0023 18.0 0.0 0.0066 16.5 0.0 1.7 1 1 1 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CCF33020.1 - 0.0051 16.7 0.2 2.6 7.9 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase SRPRB PF09439.10 CCF33020.1 - 0.028 13.9 0.0 0.033 13.6 0.0 1.1 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit FeoB_N PF02421.18 CCF33020.1 - 0.051 13.1 0.0 0.25 10.9 0.0 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_22 PF13401.6 CCF33020.1 - 0.13 12.6 0.1 0.47 10.7 0.1 2.0 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 CCF33022.1 - 3.5e-53 179.5 0.0 1e-39 135.9 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CCF33022.1 - 2.2e-08 33.8 0.0 3.1e-07 30.1 0.0 2.6 2 0 0 2 2 2 1 AAA+ lid domain AAA_16 PF13191.6 CCF33022.1 - 1.9e-06 28.3 1.4 0.08 13.3 0.6 4.0 2 2 0 3 3 3 2 AAA ATPase domain AAA_5 PF07728.14 CCF33022.1 - 4.9e-06 26.6 0.1 0.11 12.6 0.0 3.5 3 1 0 3 3 3 2 AAA domain (dynein-related subfamily) Vps4_C PF09336.10 CCF33022.1 - 6.3e-06 26.1 0.0 0.032 14.2 0.0 3.0 3 0 0 3 3 3 2 Vps4 C terminal oligomerisation domain AAA_14 PF13173.6 CCF33022.1 - 0.0002 21.4 0.0 0.12 12.4 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.6 CCF33022.1 - 0.00027 20.6 1.6 0.1 12.2 0.1 3.4 2 2 1 3 3 3 1 AAA domain CDC48_N PF02359.18 CCF33022.1 - 0.00075 19.6 0.0 0.023 14.8 0.0 2.6 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), N-terminal domain AAA_22 PF13401.6 CCF33022.1 - 0.0013 19.0 2.3 3.6 7.9 0.9 4.0 2 2 0 3 3 3 1 AAA domain AAA_28 PF13521.6 CCF33022.1 - 0.0015 18.8 0.0 0.077 13.2 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 CCF33022.1 - 0.0025 18.0 0.0 0.29 11.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 CCF33022.1 - 0.015 15.7 0.0 11 6.4 0.0 2.9 2 0 0 2 2 2 0 RNA helicase RuvB_N PF05496.12 CCF33022.1 - 0.016 15.0 0.0 0.093 12.5 0.0 2.4 2 1 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain DUF815 PF05673.13 CCF33022.1 - 0.03 13.5 0.0 0.11 11.6 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF815) DUF2075 PF09848.9 CCF33022.1 - 0.055 12.7 0.2 0.59 9.3 0.4 2.2 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2075) Torsin PF06309.11 CCF33022.1 - 0.079 13.1 0.0 0.17 12.0 0.0 1.6 1 0 0 1 1 1 0 Torsin Rad17 PF03215.15 CCF33022.1 - 0.089 12.7 0.0 0.21 11.5 0.0 1.6 1 0 0 1 1 1 0 Rad17 P-loop domain SE PF08491.10 CCF33023.1 - 2.1e-87 292.7 0.0 2.6e-87 292.4 0.0 1.1 1 0 0 1 1 1 1 Squalene epoxidase FAD_binding_3 PF01494.19 CCF33023.1 - 6.1e-10 38.9 0.3 7.3e-09 35.3 0.3 2.2 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 CCF33023.1 - 8.1e-10 38.8 0.4 8e-07 29.0 0.5 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase Thi4 PF01946.17 CCF33023.1 - 9.2e-05 21.8 0.0 0.00014 21.2 0.0 1.2 1 0 0 1 1 1 1 Thi4 family GIDA PF01134.22 CCF33023.1 - 0.00014 21.1 0.3 0.00042 19.5 0.3 1.7 1 1 0 1 1 1 1 Glucose inhibited division protein A NAD_binding_8 PF13450.6 CCF33023.1 - 0.00014 22.0 0.5 0.00036 20.7 0.5 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 CCF33023.1 - 0.0015 17.7 0.4 0.0023 17.1 0.4 1.2 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 CCF33023.1 - 0.0035 16.7 0.3 0.0062 15.9 0.3 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase ApbA PF02558.16 CCF33023.1 - 0.0042 16.7 0.1 0.0072 16.0 0.1 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Pyr_redox_2 PF07992.14 CCF33023.1 - 0.0058 15.9 0.1 0.01 15.1 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCF33023.1 - 0.0066 17.0 0.8 0.053 14.1 0.1 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_Gly3P_dh_N PF01210.23 CCF33023.1 - 0.0084 16.1 0.0 0.013 15.4 0.0 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 3HCDH_N PF02737.18 CCF33023.1 - 0.047 13.6 0.1 0.091 12.6 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Lycopene_cycl PF05834.12 CCF33023.1 - 0.054 12.5 0.0 0.12 11.4 0.1 1.5 2 0 0 2 2 2 0 Lycopene cyclase protein HI0933_like PF03486.14 CCF33023.1 - 0.087 11.5 0.1 0.13 11.0 0.1 1.2 1 0 0 1 1 1 0 HI0933-like protein Shikimate_DH PF01488.20 CCF33023.1 - 0.1 12.7 0.0 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NolB PF17398.2 CCF33024.1 - 0.062 13.7 0.0 0.096 13.1 0.0 1.3 1 0 0 1 1 1 0 Nodulation protein NolB F-box-like PF12937.7 CCF33025.1 - 0.043 13.7 1.1 0.36 10.8 0.2 2.4 2 0 0 2 2 2 0 F-box-like Pyrid_ox_like PF16242.5 CCF33026.1 - 1.7e-24 86.1 0.0 2.5e-24 85.6 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase like Putative_PNPOx PF01243.20 CCF33026.1 - 2.8e-09 37.0 0.0 6.6e-09 35.8 0.0 1.6 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase TP_methylase PF00590.20 CCF33027.1 - 6.7e-24 85.0 0.3 1.2e-23 84.2 0.3 1.4 1 1 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases DnaJ_C PF01556.18 CCF33028.1 - 3.5e-37 127.8 0.0 4.7e-37 127.4 0.0 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 CCF33028.1 - 2.4e-23 82.0 4.7 4.2e-23 81.2 4.7 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 CCF33028.1 - 1.2e-13 51.2 16.3 1.9e-13 50.6 16.3 1.3 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 CCF33028.1 - 0.0064 16.4 11.7 0.16 12.0 1.2 2.5 2 0 0 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 CCF33028.1 - 0.32 11.0 7.8 2.2 8.3 1.3 2.3 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA TackOD1 PF18551.1 CCF33028.1 - 2.5 7.8 7.0 7.5 6.2 1.4 2.2 1 1 1 2 2 2 0 Thaumarchaeal output domain 1 RseC_MucC PF04246.12 CCF33028.1 - 8.8 6.3 5.5 6.9 6.6 0.3 2.2 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC tRNA-synt_1c PF00749.21 CCF33029.1 - 5.1e-92 308.1 0.0 6.7e-92 307.7 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain TPR_1 PF00515.28 CCF33030.1 - 8.5e-19 66.5 7.1 7.3e-09 35.1 0.0 4.7 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.17 CCF33030.1 - 2.9e-16 58.2 6.9 1.2e-06 28.2 0.0 4.6 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_12 PF13424.6 CCF33030.1 - 1.7e-11 44.2 0.6 2.9e-07 30.7 0.1 3.0 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 CCF33030.1 - 1.7e-10 40.3 3.2 2.9e-06 27.0 0.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 CCF33030.1 - 6e-09 36.0 0.3 0.061 14.0 0.0 4.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 CCF33030.1 - 3.5e-08 32.9 0.2 9.8e-06 25.3 0.0 3.6 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 CCF33030.1 - 7e-08 32.0 1.7 6.4e-06 25.8 0.2 3.7 2 1 1 3 3 3 1 TPR repeat PB1 PF00564.24 CCF33030.1 - 3.3e-06 26.9 0.1 6.3e-06 26.0 0.1 1.4 1 0 0 1 1 1 1 PB1 domain TPR_9 PF13371.6 CCF33030.1 - 1.1e-05 25.5 0.1 0.19 11.9 0.0 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 CCF33030.1 - 5.4e-05 23.8 0.1 0.0061 17.2 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 CCF33030.1 - 7.2e-05 22.9 0.2 0.15 12.5 0.1 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.6 CCF33030.1 - 0.00082 19.2 1.1 0.23 11.4 0.0 3.8 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 CCF33030.1 - 0.0037 18.0 0.2 0.18 12.7 0.0 3.3 1 1 2 3 3 3 1 Tetratricopeptide repeat DUF3808 PF10300.9 CCF33030.1 - 0.084 11.6 0.0 0.14 10.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3808) TPR_4 PF07721.14 CCF33030.1 - 0.1 13.3 0.0 46 5.1 0.0 3.6 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.6 CCF33030.1 - 0.1 13.1 0.0 1.3 9.6 0.0 2.7 2 1 0 2 2 2 0 Tetratricopeptide repeat Peptidase_M43 PF05572.13 CCF33031.1 - 0.036 14.0 0.0 0.045 13.7 0.0 1.2 1 0 0 1 1 1 0 Pregnancy-associated plasma protein-A Peptidase_M57 PF12388.8 CCF33031.1 - 0.056 13.1 0.4 2.5 7.7 0.1 2.2 1 1 1 2 2 2 0 Dual-action HEIGH metallo-peptidase DUF3810 PF12725.7 CCF33031.1 - 0.06 12.7 0.0 0.077 12.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) Cpn60_TCP1 PF00118.24 CCF33032.1 - 6.8e-88 295.4 12.4 1.3e-87 294.6 12.4 1.4 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family Cofilin_ADF PF00241.20 CCF33033.1 - 1e-39 135.1 0.3 1.2e-39 134.9 0.3 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein SpoVR PF04293.13 CCF33033.1 - 0.089 11.5 0.1 0.12 11.0 0.1 1.2 1 0 0 1 1 1 0 SpoVR like protein Blt1 PF12754.7 CCF33034.1 - 5.3e-41 140.4 0.7 7.3e-41 140.0 0.7 1.2 1 0 0 1 1 1 1 Blt1 N-terminal domain Blt1_C PF17183.4 CCF33034.1 - 1.1e-13 50.6 0.8 1.7e-13 50.0 0.8 1.3 1 0 0 1 1 1 1 Get5 carboxyl domain ubiquitin PF00240.23 CCF33034.1 - 3.8e-05 23.3 0.1 6.2e-05 22.7 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 CCF33034.1 - 0.044 13.6 0.2 0.071 12.9 0.2 1.3 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Methyltr_RsmB-F PF01189.17 CCF33035.1 - 2e-40 138.6 0.0 3.6e-40 137.8 0.0 1.4 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltr_RsmF_N PF17125.5 CCF33035.1 - 2.5e-08 34.3 0.0 5.2e-08 33.3 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of 16S rRNA methyltransferase RsmF Methyltransf_25 PF13649.6 CCF33035.1 - 0.0027 18.4 0.0 0.0063 17.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 CCF33035.1 - 0.0098 15.7 0.0 0.016 15.0 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Met_10 PF02475.16 CCF33035.1 - 0.012 15.4 0.2 0.026 14.3 0.0 1.5 2 0 0 2 2 2 0 Met-10+ like-protein SWIRM-assoc_2 PF16496.5 CCF33035.1 - 9.9 4.9 10.1 14 4.4 10.1 1.2 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal WD40 PF00400.32 CCF33037.1 - 2.8e-12 46.9 0.0 0.017 16.0 0.0 4.7 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF33037.1 - 8e-05 22.9 0.0 1.5 9.2 0.0 4.1 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain EIF_2_alpha PF07541.12 CCF33038.1 - 3.8e-37 126.9 0.0 7.7e-37 125.9 0.0 1.5 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 CCF33038.1 - 4.3e-14 52.6 0.9 8.9e-14 51.6 0.9 1.6 1 0 0 1 1 1 1 S1 RNA binding domain adh_short PF00106.25 CCF33039.1 - 8.4e-07 28.6 0.0 9.7e-07 28.4 0.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF33039.1 - 8.9e-07 28.7 0.0 1.1e-06 28.4 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase XhlA PF10779.9 CCF33039.1 - 0.029 14.5 0.0 0.046 13.9 0.0 1.2 1 0 0 1 1 1 0 Haemolysin XhlA KR PF08659.10 CCF33039.1 - 0.03 14.2 0.0 0.04 13.8 0.0 1.1 1 0 0 1 1 1 0 KR domain Aldo_ket_red PF00248.21 CCF33041.1 - 3.8e-48 164.2 0.0 2.4e-46 158.3 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family UDPGT PF00201.18 CCF33041.1 - 0.11 11.3 0.0 0.15 10.8 0.0 1.1 1 0 0 1 1 1 0 UDP-glucoronosyl and UDP-glucosyl transferase HIT PF01230.23 CCF33042.1 - 8.7e-18 64.9 0.0 1.6e-17 64.1 0.0 1.3 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 CCF33042.1 - 4.6e-06 27.1 0.0 9.3e-06 26.1 0.0 1.4 2 0 0 2 2 2 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 CCF33042.1 - 2.7e-05 24.0 0.0 6.9e-05 22.7 0.0 1.7 2 0 0 2 2 2 1 Protein similar to CwfJ C-terminus 1 DUF2267 PF10025.9 CCF33042.1 - 0.042 14.1 0.2 0.09 13.1 0.2 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2267) DNA_RNApol_7kD PF03604.13 CCF33043.1 - 3.6e-15 55.3 8.1 4.6e-15 55.0 8.1 1.1 1 0 0 1 1 1 1 DNA directed RNA polymerase, 7 kDa subunit GATA PF00320.27 CCF33043.1 - 0.0026 17.3 0.1 0.0026 17.3 0.1 2.2 2 1 0 2 2 2 1 GATA zinc finger Zn-ribbon_8 PF09723.10 CCF33043.1 - 0.0081 16.3 2.2 0.013 15.6 2.2 1.3 1 0 0 1 1 1 1 Zinc ribbon domain HypA PF01155.19 CCF33043.1 - 0.012 15.7 0.4 0.012 15.7 0.4 1.1 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA GFA PF04828.14 CCF33043.1 - 0.022 15.1 1.5 2.9 8.3 0.4 2.1 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme Zn_ribbon_SprT PF17283.2 CCF33043.1 - 0.081 12.9 3.3 0.14 12.1 3.3 1.4 1 0 0 1 1 1 0 SprT-like zinc ribbon domain FYDLN_acid PF09538.10 CCF33043.1 - 0.21 12.3 0.7 0.28 11.9 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) VWA_N2 PF16164.5 CCF33043.1 - 0.35 11.0 2.7 2.1 8.6 0.4 2.0 1 1 1 2 2 2 0 VWA N-terminal zf_UBZ PF18439.1 CCF33043.1 - 0.62 9.7 3.2 9.3 5.9 0.1 2.1 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger TF_Zn_Ribbon PF08271.12 CCF33043.1 - 0.75 9.4 6.5 0.93 9.1 0.1 2.2 1 1 2 3 3 2 0 TFIIB zinc-binding ATP_bind_1 PF03029.17 CCF33044.1 - 3.9e-72 242.9 0.0 5.3e-72 242.5 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_24 PF13479.6 CCF33044.1 - 5.2e-05 23.0 0.0 9.5e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain GTP_EFTU PF00009.27 CCF33044.1 - 0.00018 21.1 0.0 0.035 13.7 0.0 2.8 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 CCF33044.1 - 0.00024 21.2 0.0 0.0051 16.9 0.0 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 CCF33044.1 - 0.00029 21.3 0.0 0.00066 20.1 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 CCF33044.1 - 0.0013 19.0 0.0 0.0055 17.0 0.0 2.1 3 0 0 3 3 2 1 AAA domain PRK PF00485.18 CCF33044.1 - 0.0014 18.4 0.0 0.0039 16.9 0.0 1.8 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family MeaB PF03308.16 CCF33044.1 - 0.0015 17.6 0.0 0.34 9.8 0.0 2.4 2 1 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_33 PF13671.6 CCF33044.1 - 0.0016 18.6 0.7 0.023 14.8 0.0 2.6 3 0 0 3 3 2 1 AAA domain Zeta_toxin PF06414.12 CCF33044.1 - 0.0023 17.2 0.2 0.0059 15.9 0.0 1.7 2 0 0 2 2 2 1 Zeta toxin NACHT PF05729.12 CCF33044.1 - 0.0026 17.7 0.0 0.005 16.8 0.0 1.4 1 0 0 1 1 1 1 NACHT domain NB-ARC PF00931.22 CCF33044.1 - 0.0028 16.9 0.0 0.0092 15.2 0.0 1.7 2 0 0 2 2 2 1 NB-ARC domain G-alpha PF00503.20 CCF33044.1 - 0.0034 16.6 0.0 0.11 11.6 0.0 2.3 2 0 0 2 2 2 1 G-protein alpha subunit cobW PF02492.19 CCF33044.1 - 0.0037 16.9 0.1 0.04 13.5 0.1 2.3 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain SRP54 PF00448.22 CCF33044.1 - 0.0053 16.4 0.0 0.031 13.9 0.0 2.2 3 0 0 3 3 2 1 SRP54-type protein, GTPase domain AAA_30 PF13604.6 CCF33044.1 - 0.0074 16.0 0.0 0.014 15.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 CCF33044.1 - 0.0086 16.0 0.1 8.4 6.3 0.0 3.0 3 0 0 3 3 3 0 RsgA GTPase FeoB_N PF02421.18 CCF33044.1 - 0.0093 15.5 0.1 0.17 11.4 0.0 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B Arf PF00025.21 CCF33044.1 - 0.017 14.6 0.0 2.8 7.4 0.0 2.4 2 0 0 2 2 2 0 ADP-ribosylation factor family Roc PF08477.13 CCF33044.1 - 0.017 15.4 0.0 2.7 8.2 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 CCF33044.1 - 0.031 13.9 0.0 2.8 7.5 0.0 2.7 2 1 0 2 2 2 0 Ras family ATPase_2 PF01637.18 CCF33044.1 - 0.032 14.1 0.1 0.075 12.9 0.0 1.6 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea Pox_A32 PF04665.12 CCF33044.1 - 0.047 13.1 0.5 0.45 9.9 0.0 2.5 3 0 0 3 3 3 0 Poxvirus A32 protein SRPRB PF09439.10 CCF33044.1 - 0.066 12.6 0.4 9.2 5.7 0.0 2.7 3 0 0 3 3 3 0 Signal recognition particle receptor beta subunit AAA_23 PF13476.6 CCF33044.1 - 0.09 13.3 0.0 1.2 9.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 CCF33044.1 - 0.1 13.1 0.0 0.1 13.1 0.0 2.5 2 1 1 3 3 1 0 AAA domain KAP_NTPase PF07693.14 CCF33044.1 - 0.12 11.6 0.0 0.24 10.6 0.0 1.7 1 1 0 1 1 1 0 KAP family P-loop domain CLP1_P PF16575.5 CCF33044.1 - 0.17 11.7 0.1 1.6 8.5 0.0 2.3 3 0 0 3 3 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop Viral_helicase1 PF01443.18 CCF33044.1 - 0.18 11.5 0.0 0.27 10.9 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Cwf_Cwc_15 PF04889.12 CCF33044.1 - 4.3 7.0 10.9 7.3 6.3 10.9 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CwfJ_C_1 PF04677.15 CCF33045.1 - 1.4e-27 96.0 0.0 2.4e-27 95.2 0.0 1.4 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.14 CCF33045.1 - 1.2e-26 93.4 0.1 1.2e-26 93.4 0.1 2.7 2 0 0 2 2 2 1 Protein similar to CwfJ C-terminus 2 FumaraseC_C PF10415.9 CCF33045.1 - 0.15 12.5 0.1 4.4 7.8 0.1 2.8 2 0 0 2 2 2 0 Fumarase C C-terminus PAP_assoc PF03828.19 CCF33047.1 - 2.5e-18 66.0 0.1 6.1e-18 64.8 0.1 1.7 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 CCF33047.1 - 5.9e-07 29.7 0.0 1.1e-06 28.9 0.0 1.4 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 CCF33047.1 - 0.15 12.1 0.0 0.29 11.3 0.0 1.4 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase VHS PF00790.19 CCF33049.1 - 2.9e-23 82.3 0.0 4.8e-23 81.6 0.0 1.3 1 0 0 1 1 1 1 VHS domain GAT PF03127.14 CCF33049.1 - 6.3e-07 29.6 0.3 1.5e-06 28.4 0.3 1.7 1 0 0 1 1 1 1 GAT domain YliH PF10799.8 CCF33049.1 - 0.17 11.8 0.6 0.5 10.3 0.1 2.0 2 0 0 2 2 2 0 Biofilm formation protein (YliH/bssR) RAP1 PF07218.11 CCF33049.1 - 0.23 9.7 2.6 0.28 9.4 2.6 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) PRK PF00485.18 CCF33050.1 - 7.2e-07 29.1 0.0 1e-06 28.7 0.0 1.3 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_16 PF13191.6 CCF33050.1 - 1.8e-05 25.2 0.1 2.7e-05 24.6 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 CCF33050.1 - 2.2e-05 24.9 0.0 3.9e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 CCF33050.1 - 0.0001 22.8 0.0 0.0003 21.4 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 CCF33050.1 - 0.00021 21.3 0.0 0.0006 19.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.12 CCF33050.1 - 0.00021 20.6 0.1 0.002 17.4 0.0 2.2 2 0 0 2 2 2 1 Zeta toxin NACHT PF05729.12 CCF33050.1 - 0.0005 20.0 0.0 0.0014 18.6 0.0 1.8 2 0 0 2 2 2 1 NACHT domain AAA_22 PF13401.6 CCF33050.1 - 0.00075 19.8 0.0 0.0037 17.6 0.0 2.0 1 1 1 2 2 2 1 AAA domain AAA_30 PF13604.6 CCF33050.1 - 0.001 18.8 0.0 0.0017 18.1 0.0 1.5 1 1 0 1 1 1 1 AAA domain NB-ARC PF00931.22 CCF33050.1 - 0.0016 17.7 0.0 0.0027 16.9 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain TsaE PF02367.17 CCF33050.1 - 0.0019 18.2 0.0 0.04 13.9 0.0 2.2 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 CCF33050.1 - 0.0024 18.1 0.0 0.011 15.9 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 CCF33050.1 - 0.0029 17.2 0.0 0.0048 16.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 CCF33050.1 - 0.0053 17.1 0.0 0.0094 16.3 0.0 1.4 1 0 0 1 1 1 1 RNA helicase AAA_28 PF13521.6 CCF33050.1 - 0.0067 16.7 0.0 0.016 15.4 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 CCF33050.1 - 0.0079 16.5 0.1 0.013 15.8 0.1 1.5 1 1 0 1 1 1 1 AAA domain Rad17 PF03215.15 CCF33050.1 - 0.011 15.6 0.0 0.017 15.0 0.0 1.2 1 0 0 1 1 1 0 Rad17 P-loop domain NTPase_1 PF03266.15 CCF33050.1 - 0.016 15.1 0.0 0.04 13.8 0.0 1.6 1 0 0 1 1 1 0 NTPase RuvB_N PF05496.12 CCF33050.1 - 0.02 14.6 0.0 0.04 13.7 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain ABC_tran PF00005.27 CCF33050.1 - 0.021 15.3 0.0 0.044 14.3 0.0 1.5 1 0 0 1 1 1 0 ABC transporter AAA_24 PF13479.6 CCF33050.1 - 0.052 13.3 0.0 0.088 12.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 CCF33050.1 - 0.053 12.9 0.0 0.091 12.1 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Cytidylate_kin PF02224.18 CCF33050.1 - 0.059 13.1 0.2 0.11 12.3 0.2 1.4 1 0 0 1 1 1 0 Cytidylate kinase AAA_17 PF13207.6 CCF33050.1 - 0.093 13.1 0.4 0.37 11.2 0.0 2.1 3 0 0 3 3 2 0 AAA domain ATPase_2 PF01637.18 CCF33050.1 - 0.095 12.6 0.0 0.16 11.9 0.0 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_11 PF13086.6 CCF33050.1 - 0.097 12.4 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 CCF33050.1 - 0.12 11.5 0.0 0.16 11.0 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein SRP54 PF00448.22 CCF33050.1 - 0.15 11.6 0.0 0.23 11.0 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Viral_helicase1 PF01443.18 CCF33050.1 - 0.16 11.6 0.0 0.27 11.0 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Glyco_hydro_3 PF00933.21 CCF33051.1 - 1.6e-53 182.2 0.0 2.1e-53 181.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.22 CCF33051.1 - 5.4e-07 29.8 0.0 0.0001 22.3 0.0 2.2 1 1 1 2 2 2 2 Glycosyl hydrolase family 3 C-terminal domain adh_short PF00106.25 CCF33052.1 - 1.2e-10 41.2 1.1 1.3e-10 41.0 1.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF33052.1 - 1.3e-05 24.9 0.7 1.6e-05 24.6 0.7 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF33052.1 - 0.0045 16.9 0.6 0.0055 16.6 0.6 1.1 1 0 0 1 1 1 1 KR domain ADH_N PF08240.12 CCF33053.1 - 3.2e-30 104.2 3.2 3.5e-30 104.1 3.2 1.0 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Myosin_head PF00063.21 CCF33055.1 - 4.3e-268 891.1 0.0 1.2e-267 889.6 0.0 1.8 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_N PF02736.19 CCF33055.1 - 2.5e-12 46.4 0.6 6e-12 45.2 0.6 1.7 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain Myosin_tail_1 PF01576.19 CCF33055.1 - 5.6e-10 37.7 119.0 5.6e-10 37.7 119.0 5.8 2 2 1 3 3 3 1 Myosin tail AAA_22 PF13401.6 CCF33055.1 - 0.087 13.1 0.0 0.087 13.1 0.0 4.5 4 0 0 4 4 4 0 AAA domain UDPG_MGDP_dh_N PF03721.14 CCF33055.1 - 0.55 9.8 2.2 1.6 8.2 2.2 1.8 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain zf-C3H1 PF10650.9 CCF33056.1 - 0.018 14.7 0.7 0.029 14.1 0.7 1.3 1 0 0 1 1 1 0 Putative zinc-finger domain DUF4201 PF13870.6 CCF33056.1 - 0.15 11.8 11.2 0.013 15.2 5.6 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) V_ATPase_I PF01496.19 CCF33056.1 - 1.6 6.5 4.0 3.7 5.4 4.0 1.5 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RTA1 PF04479.13 CCF33057.1 - 1.3e-74 250.3 3.6 1.3e-74 250.3 3.6 1.5 1 1 1 2 2 2 1 RTA1 like protein CAP PF00188.26 CCF33058.1 - 1.2e-19 71.4 1.9 1.6e-19 71.0 1.9 1.1 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Med13_C PF06333.12 CCF33058.1 - 0.024 13.9 5.2 0.037 13.3 5.2 1.2 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain MoaE PF02391.17 CCF33059.1 - 1.4e-38 131.6 0.0 1.8e-38 131.3 0.0 1.1 1 0 0 1 1 1 1 MoaE protein G-patch PF01585.23 CCF33060.1 - 1.2e-11 44.3 3.1 2.4e-11 43.3 3.1 1.5 1 0 0 1 1 1 1 G-patch domain RRM_1 PF00076.22 CCF33060.1 - 3.8e-07 29.8 0.0 0.015 15.1 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) G-patch_2 PF12656.7 CCF33060.1 - 5.7e-06 26.3 1.7 1.7e-05 24.8 1.7 1.8 1 0 0 1 1 1 1 G-patch domain zf-RanBP PF00641.18 CCF33060.1 - 7.7e-05 21.9 5.1 0.00017 20.9 5.1 1.5 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others RED_N PF07808.13 CCF33060.1 - 0.0017 18.0 3.8 0.0017 18.0 3.8 1.6 2 0 0 2 2 2 1 RED-like protein N-terminal region zf-C2H2_2 PF12756.7 CCF33060.1 - 0.03 14.6 1.1 0.055 13.8 0.5 1.7 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 CCF33060.1 - 5.4 7.4 8.5 0.48 10.8 3.3 1.9 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Choline_kinase PF01633.20 CCF33061.1 - 7.7e-56 189.0 0.9 6e-55 186.1 0.0 2.2 2 0 0 2 2 2 1 Choline/ethanolamine kinase Choline_kin_N PF04428.14 CCF33061.1 - 3.9e-21 74.5 0.0 7.7e-21 73.5 0.0 1.5 1 0 0 1 1 1 1 Choline kinase N terminus APH PF01636.23 CCF33061.1 - 0.00019 21.4 2.2 0.00048 20.1 0.1 2.5 2 0 0 2 2 2 1 Phosphotransferase enzyme family TFIIA PF03153.13 CCF33061.1 - 2.2 8.2 13.8 2.4 8.0 10.3 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Methyltransf_23 PF13489.6 CCF33062.1 - 1e-20 74.2 0.0 1.7e-20 73.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF33062.1 - 8.6e-12 45.6 0.1 3.3e-11 43.7 0.1 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF33062.1 - 3.8e-09 37.2 0.0 2.3e-08 34.7 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF33062.1 - 1.9e-07 31.7 0.0 4e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF33062.1 - 2e-07 30.9 0.0 0.00047 20.0 0.1 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_16 PF10294.9 CCF33062.1 - 0.00051 19.8 0.0 0.00076 19.3 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase MTS PF05175.14 CCF33062.1 - 0.0015 18.1 0.0 0.0042 16.6 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 CCF33062.1 - 0.0024 17.3 0.0 0.0037 16.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_4 PF02390.17 CCF33062.1 - 0.03 13.8 0.0 0.057 12.9 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase CMAS PF02353.20 CCF33062.1 - 0.034 13.5 0.0 0.048 13.0 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.18 CCF33062.1 - 0.043 13.1 0.0 0.32 10.3 0.0 2.1 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family FtsJ PF01728.19 CCF33062.1 - 0.059 13.5 0.1 0.12 12.5 0.0 1.5 2 0 0 2 2 2 0 FtsJ-like methyltransferase DUF938 PF06080.12 CCF33062.1 - 0.086 12.6 0.0 0.14 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Methyltransf_2 PF00891.18 CCF33062.1 - 0.09 12.1 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase domain PCMT PF01135.19 CCF33062.1 - 0.21 11.3 0.0 0.31 10.8 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) FAD_binding_3 PF01494.19 CCF33063.1 - 2.8e-23 82.7 0.0 1.5e-22 80.4 0.0 1.9 1 1 0 1 1 1 1 FAD binding domain Amino_oxidase PF01593.24 CCF33063.1 - 8.4e-06 25.3 0.3 0.0015 17.9 0.0 2.2 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CCF33063.1 - 0.0067 16.6 0.1 0.029 14.6 0.1 2.2 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 CCF33063.1 - 0.046 14.3 1.6 0.19 12.3 0.1 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CCF33063.1 - 0.062 12.5 0.1 7.9 5.6 0.0 2.5 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Mito_carr PF00153.27 CCF33065.1 - 1.2e-67 223.9 0.9 8.8e-25 86.5 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Tim17 PF02466.19 CCF33065.1 - 0.025 14.9 1.1 0.13 12.6 1.1 2.4 1 1 0 1 1 1 0 Tim17/Tim22/Tim23/Pmp24 family Serine_protease PF18405.1 CCF33065.1 - 0.39 9.8 3.0 3.4 6.7 0.0 3.2 3 2 1 4 4 4 0 Gammaproteobacterial serine protease RCC1 PF00415.18 CCF33066.1 - 5.6e-20 71.7 0.4 7.9e-06 26.4 0.1 5.2 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.31 CCF33066.1 - 7.7e-14 51.9 0.0 2.1e-08 34.4 0.0 2.5 2 0 0 2 2 2 2 BTB/POZ domain Ank_4 PF13637.6 CCF33066.1 - 5.7e-10 39.5 0.9 6e-09 36.3 0.1 3.0 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 CCF33066.1 - 6.9e-07 29.8 0.1 2.2e-06 28.1 0.1 1.8 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) RCC1_2 PF13540.6 CCF33066.1 - 1.2e-06 28.2 0.7 1.2e-06 28.2 0.7 3.7 5 0 0 5 5 5 1 Regulator of chromosome condensation (RCC1) repeat Ank_3 PF13606.6 CCF33066.1 - 1e-05 25.5 0.1 0.16 12.6 0.1 3.0 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 CCF33066.1 - 0.0079 16.5 0.0 0.25 11.7 0.1 3.2 3 0 0 3 3 3 1 Ankyrin repeats (many copies) F-box-like_2 PF13013.6 CCF33066.1 - 0.06 13.3 0.1 1.5 8.8 0.1 2.5 2 0 0 2 2 2 0 F-box-like domain Metallothio_6 PF05522.11 CCF33069.1 - 0.22 12.1 20.4 5 7.7 9.6 2.2 1 1 1 2 2 2 0 Metallothionein UPF0506 PF11703.8 CCF33069.1 - 0.89 10.0 20.9 6 7.3 5.4 2.9 1 1 1 2 2 2 0 UPF0506 Ribosomal_L31 PF01197.18 CCF33070.1 - 4.8e-06 26.7 0.0 7.9e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L31 Flavin_Reduct PF01613.18 CCF33071.1 - 3.3e-34 118.2 0.0 4.4e-34 117.8 0.0 1.2 1 0 0 1 1 1 1 Flavin reductase like domain HSP90 PF00183.18 CCF33072.1 - 1.2e-222 740.4 35.2 1.5e-222 740.1 35.2 1.1 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 CCF33072.1 - 4.9e-15 56.0 0.1 9.3e-15 55.1 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 CCF33072.1 - 7.8e-10 38.7 0.1 2.9e-09 36.9 0.1 2.0 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase LOH1CR12 PF10158.9 CCF33072.1 - 0.036 14.1 0.3 0.13 12.3 0.3 1.9 1 0 0 1 1 1 0 Tumour suppressor protein CFIA_Pcf11 PF11526.8 CCF33074.1 - 2.8e-07 30.9 2.1 7.8e-07 29.5 2.1 1.7 1 1 0 1 1 1 1 Subunit of cleavage factor IA Pcf11 CTD_bind PF04818.13 CCF33074.1 - 4.2e-06 27.5 0.0 3.1e-05 24.7 0.0 2.5 2 0 0 2 2 2 1 RNA polymerase II-binding domain. VHS PF00790.19 CCF33074.1 - 0.0011 18.8 0.0 0.0033 17.3 0.0 1.7 2 0 0 2 2 2 1 VHS domain zf-C2H2_4 PF13894.6 CCF33074.1 - 0.045 14.6 3.4 2.1 9.4 0.5 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2HC_2 PF13913.6 CCF33074.1 - 0.95 9.4 4.2 3 7.9 0.8 2.4 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf_UBZ PF18439.1 CCF33074.1 - 2.1 8.0 8.4 0.85 9.3 2.6 2.8 2 1 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-C2H2 PF00096.26 CCF33074.1 - 8.9 7.0 6.9 15 6.2 0.5 3.0 3 0 0 3 3 3 0 Zinc finger, C2H2 type ABC_tran PF00005.27 CCF33075.1 - 1.2e-33 116.6 0.0 2.4e-33 115.5 0.0 1.6 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 CCF33075.1 - 2.9e-16 60.0 0.7 4.1e-16 59.5 0.7 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 CCF33075.1 - 2.8e-05 23.7 0.0 0.0012 18.3 0.0 2.2 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 CCF33075.1 - 0.0014 18.9 0.1 0.012 15.9 0.1 2.2 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 CCF33075.1 - 0.0031 17.9 0.3 0.052 14.0 0.3 2.5 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CCF33075.1 - 0.0061 17.0 0.1 0.015 15.7 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain ABC_ATPase PF09818.9 CCF33075.1 - 0.011 14.6 0.1 0.017 13.9 0.1 1.2 1 0 0 1 1 1 0 Predicted ATPase of the ABC class AAA_5 PF07728.14 CCF33075.1 - 0.015 15.3 0.1 0.072 13.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 CCF33075.1 - 0.057 13.1 0.1 0.23 11.2 0.1 1.8 1 1 0 1 1 1 0 AAA domain Sigma54_activ_2 PF14532.6 CCF33075.1 - 0.081 13.0 0.0 0.87 9.7 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain SbcCD_C PF13558.6 CCF33075.1 - 0.094 13.0 2.1 2.1 8.6 2.0 2.7 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit IstB_IS21 PF01695.17 CCF33075.1 - 0.095 12.4 0.8 1.4 8.7 0.0 2.6 2 1 1 3 3 3 0 IstB-like ATP binding protein AAA_29 PF13555.6 CCF33075.1 - 0.1 12.4 0.0 0.25 11.1 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Hydrolase_4 PF12146.8 CCF33076.1 - 1.3e-48 165.4 0.0 1.6e-48 165.1 0.0 1.0 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CCF33076.1 - 1.7e-12 48.4 0.6 2.1e-12 48.1 0.6 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CCF33076.1 - 2.4e-11 43.8 0.3 7.5e-11 42.2 0.2 1.6 1 1 1 2 2 2 1 alpha/beta hydrolase fold Chlorophyllase PF07224.11 CCF33076.1 - 0.001 18.1 0.0 0.0015 17.6 0.0 1.1 1 0 0 1 1 1 1 Chlorophyllase Chlorophyllase2 PF12740.7 CCF33076.1 - 0.0076 15.2 0.0 0.011 14.6 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme Peptidase_S9 PF00326.21 CCF33076.1 - 0.011 15.2 0.1 0.15 11.5 0.0 2.1 2 0 0 2 2 2 0 Prolyl oligopeptidase family Esterase PF00756.20 CCF33076.1 - 0.022 14.4 0.0 0.032 13.9 0.0 1.4 1 1 0 1 1 1 0 Putative esterase Lipase_3 PF01764.25 CCF33076.1 - 0.15 11.9 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) PGAP1 PF07819.13 CCF33076.1 - 0.18 11.5 0.0 0.26 11.0 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein Cation_efflux PF01545.21 CCF33077.1 - 2e-13 50.5 8.1 2.8e-13 50.0 8.1 1.2 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 CCF33077.1 - 5.1e-05 23.3 0.4 0.0001 22.3 0.4 1.5 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter DUF2207 PF09972.9 CCF33077.1 - 0.14 10.9 0.1 0.25 10.0 0.1 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) HATPase_c_3 PF13589.6 CCF33079.1 - 1.1e-15 57.7 0.5 2.3e-15 56.6 0.5 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 CCF33079.1 - 3.5e-09 37.2 0.1 1e-08 35.7 0.1 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DNA_mis_repair PF01119.19 CCF33079.1 - 2.2e-05 24.1 0.0 6.8e-05 22.5 0.0 1.9 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain DMRL_synthase PF00885.19 CCF33080.1 - 4.7e-58 195.0 0.1 5.7e-58 194.8 0.1 1.1 1 0 0 1 1 1 1 6,7-dimethyl-8-ribityllumazine synthase RXT2_N PF08595.11 CCF33081.1 - 0.034 14.2 3.2 0.22 11.5 2.5 2.3 2 0 0 2 2 2 0 RXT2-like, N-terminal DNA_pol_phi PF04931.13 CCF33081.1 - 4.5 5.2 7.2 6.7 4.7 7.2 1.1 1 0 0 1 1 1 0 DNA polymerase phi Oxidored_FMN PF00724.20 CCF33082.1 - 2.6e-90 303.2 0.0 3e-90 302.9 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family 7tm_2 PF00002.24 CCF33084.1 - 6.9e-13 48.5 4.5 6.9e-13 48.5 4.5 1.6 2 0 0 2 2 2 1 7 transmembrane receptor (Secretin family) Dicty_CAR PF05462.11 CCF33084.1 - 2.1e-11 43.6 4.4 2.1e-11 43.6 4.4 1.9 2 0 0 2 2 2 1 Slime mold cyclic AMP receptor 7tm_1 PF00001.21 CCF33084.1 - 4.2e-08 32.9 2.3 5.7e-08 32.4 2.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Git3 PF11710.8 CCF33084.1 - 6.6e-07 29.3 8.1 1.4e-06 28.3 8.1 1.5 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 Frizzled PF01534.17 CCF33084.1 - 0.00024 20.3 1.6 0.00024 20.3 1.6 2.4 2 1 1 3 3 3 2 Frizzled/Smoothened family membrane region 7TM_GPCR_Srsx PF10320.9 CCF33084.1 - 0.00046 19.7 2.8 0.00046 19.7 2.8 1.7 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx STE3 PF02076.15 CCF33084.1 - 0.0028 16.9 4.7 0.0028 16.9 4.7 2.5 2 2 0 2 2 2 1 Pheromone A receptor TMEMspv1-c74-12 PF11044.8 CCF33084.1 - 0.058 13.4 0.4 0.14 12.2 0.4 1.6 1 0 0 1 1 1 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein CitMHS PF03600.16 CCF33084.1 - 0.065 12.4 0.2 0.087 12.0 0.2 1.3 1 0 0 1 1 1 0 Citrate transporter CoA_transf_3 PF02515.17 CCF33087.1 - 4.5e-67 226.8 0.0 5.8e-67 226.4 0.0 1.1 1 0 0 1 1 1 1 CoA-transferase family III Nudix_N PF12535.8 CCF33087.1 - 0.011 15.4 0.0 0.025 14.2 0.0 1.6 1 0 0 1 1 1 0 Hydrolase of X-linked nucleoside diphosphate N terminal DUF2484 PF10658.9 CCF33087.1 - 0.15 12.4 0.0 0.29 11.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2484) adh_short PF00106.25 CCF33088.1 - 2.7e-22 79.2 0.3 4.2e-18 65.5 0.1 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCF33088.1 - 1.6e-10 41.0 0.4 1.6e-09 37.7 0.4 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF33088.1 - 1.5e-06 28.3 0.1 2.7e-06 27.4 0.1 1.4 1 0 0 1 1 1 1 KR domain DUF1849 PF08904.11 CCF33088.1 - 0.083 12.4 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1849) Dynamin_M PF01031.20 CCF33089.1 - 4.4e-102 341.1 0.0 8.5e-102 340.2 0.0 1.5 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.23 CCF33089.1 - 7.4e-57 192.1 0.0 1.4e-56 191.2 0.0 1.5 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 CCF33089.1 - 9.3e-30 102.6 4.6 9.3e-30 102.6 4.6 2.2 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 CCF33089.1 - 2.2e-05 24.5 0.1 0.00023 21.2 0.1 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_15 PF13175.6 CCF33089.1 - 0.26 11.0 3.8 2.4 7.8 0.1 2.5 3 0 0 3 3 3 0 AAA ATPase domain RPE65 PF03055.15 CCF33090.1 - 5.3e-122 408.3 0.0 6e-122 408.1 0.0 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein DUF397 PF04149.12 CCF33090.1 - 0.027 14.5 0.0 0.054 13.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF397) Sugar_tr PF00083.24 CCF33091.1 - 1.3e-122 409.9 20.2 1.6e-122 409.6 20.2 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF33091.1 - 1.8e-22 79.8 37.6 3.1e-18 65.9 13.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Cupin_2 PF07883.11 CCF33093.1 - 2.2e-15 56.1 0.2 4.3e-15 55.2 0.1 1.6 2 0 0 2 2 2 1 Cupin domain Cupin_1 PF00190.22 CCF33093.1 - 0.00042 20.0 0.0 0.00063 19.4 0.0 1.3 1 0 0 1 1 1 1 Cupin ARD PF03079.14 CCF33093.1 - 0.00082 19.6 0.2 0.0022 18.2 0.0 1.8 2 0 0 2 2 2 1 ARD/ARD' family AraC_binding PF02311.19 CCF33093.1 - 0.0036 17.2 0.0 0.0057 16.6 0.0 1.3 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_6 PF12852.7 CCF33093.1 - 0.018 14.8 0.0 0.024 14.4 0.0 1.2 1 0 0 1 1 1 0 Cupin JmjC PF02373.22 CCF33093.1 - 0.023 15.1 0.0 0.04 14.3 0.0 1.4 1 0 0 1 1 1 0 JmjC domain, hydroxylase Cupin_3 PF05899.12 CCF33093.1 - 0.023 14.4 0.1 0.046 13.4 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF861) Luteo_Vpg PF01659.16 CCF33093.1 - 0.2 12.0 2.8 0.34 11.3 2.8 1.3 1 0 0 1 1 1 0 Luteovirus putative VPg genome linked protein DAPG_hydrolase PF18089.1 CCF33094.1 - 2.1e-79 266.3 0.4 2.5e-79 266.0 0.4 1.1 1 0 0 1 1 1 1 DAPG hydrolase PhiG domain ADH_N PF08240.12 CCF33097.1 - 9.9e-14 51.1 0.1 1.2e-13 50.9 0.1 1.1 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_N_assoc PF13823.6 CCF33097.1 - 0.044 13.7 0.0 0.15 12.0 0.0 1.8 2 0 0 2 2 2 0 Alcohol dehydrogenase GroES-associated Myosin_head PF00063.21 CCF33098.1 - 8.9e-76 255.5 0.0 3.2e-74 250.4 0.0 2.0 1 1 0 1 1 1 1 Myosin head (motor domain) Cyt-b5 PF00173.28 CCF33098.1 - 3.1e-13 49.7 0.1 5.6e-10 39.2 0.1 2.8 2 0 0 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain AAA_25 PF13481.6 CCF33098.1 - 0.016 14.8 0.1 0.27 10.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 CCF33098.1 - 0.022 15.3 1.3 0.091 13.3 0.0 2.4 2 0 0 2 2 2 0 ABC transporter RsgA_GTPase PF03193.16 CCF33098.1 - 0.032 14.2 0.0 0.094 12.6 0.0 1.8 1 0 0 1 1 1 0 RsgA GTPase AAA_29 PF13555.6 CCF33098.1 - 0.037 13.8 0.1 0.1 12.4 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 CCF33098.1 - 0.058 13.5 0.2 2.6 8.2 0.1 2.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_16 PF13191.6 CCF33098.1 - 0.072 13.5 4.5 0.17 12.3 0.1 3.2 4 0 0 4 4 4 0 AAA ATPase domain VirD1 PF07328.11 CCF33098.1 - 0.12 12.3 0.1 0.31 11.0 0.1 1.6 1 0 0 1 1 1 0 T-DNA border endonuclease VirD1 RNA_helicase PF00910.22 CCF33098.1 - 0.13 12.6 0.0 0.59 10.5 0.0 2.1 2 0 0 2 2 2 0 RNA helicase AAA_23 PF13476.6 CCF33098.1 - 0.2 12.1 1.5 0.68 10.4 0.1 2.4 2 0 0 2 2 2 0 AAA domain WD40 PF00400.32 CCF33101.1 - 6e-30 102.9 14.1 1.1e-06 29.2 0.0 7.6 8 0 0 8 8 7 5 WD domain, G-beta repeat F-box-like PF12937.7 CCF33101.1 - 9.4e-08 31.8 0.0 2.1e-07 30.7 0.0 1.6 1 0 0 1 1 1 1 F-box-like ANAPC4_WD40 PF12894.7 CCF33101.1 - 1.8e-07 31.4 0.0 0.032 14.5 0.0 4.8 2 1 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain F-box PF00646.33 CCF33101.1 - 1.2e-06 28.2 0.0 2.9e-06 27.0 0.0 1.7 1 0 0 1 1 1 1 F-box domain Nup160 PF11715.8 CCF33101.1 - 0.00013 20.8 0.9 1.3 7.6 0.0 3.6 1 1 3 4 4 4 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 CCF33101.1 - 0.0038 15.8 0.0 0.0066 15.0 0.0 1.3 1 0 0 1 1 1 1 Cytochrome D1 heme domain PQQ_2 PF13360.6 CCF33101.1 - 0.039 13.5 0.1 0.16 11.6 0.1 1.9 1 1 0 1 1 1 0 PQQ-like domain Ge1_WD40 PF16529.5 CCF33101.1 - 0.054 12.4 0.3 0.16 10.9 0.0 1.8 2 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein STE PF02200.16 CCF33101.1 - 0.11 12.9 0.2 12 6.4 0.0 2.5 2 0 0 2 2 2 0 STE like transcription factor PQQ PF01011.21 CCF33101.1 - 0.13 12.2 0.2 6.6 6.9 0.0 3.6 5 0 0 5 5 5 0 PQQ enzyme repeat BRK PF07533.16 CCF33101.1 - 0.13 11.9 0.0 37 4.0 0.0 3.3 3 0 0 3 3 3 0 BRK domain eIF-3_zeta PF05091.12 CCF33102.1 - 1.2e-202 674.5 0.0 1.5e-202 674.3 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF569 PF04601.13 CCF33102.1 - 0.084 12.6 0.1 0.17 11.5 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF569) bZIP_1 PF00170.21 CCF33103.1 - 2.3e-05 24.4 8.4 2.3e-05 24.4 8.4 1.6 2 0 0 2 2 2 1 bZIP transcription factor PAP1 PF08601.10 CCF33103.1 - 0.051 13.3 5.3 0.9 9.2 0.0 2.3 2 0 0 2 2 2 0 Transcription factor PAP1 bZIP_2 PF07716.15 CCF33103.1 - 0.79 9.9 9.9 3.3 7.9 9.9 2.0 1 1 0 1 1 1 0 Basic region leucine zipper ARS2 PF04959.13 CCF33103.1 - 9.2 6.6 10.2 5.5 7.3 2.0 2.6 2 1 0 2 2 2 0 Arsenite-resistance protein 2 Zn_clus PF00172.18 CCF33104.1 - 3.7e-10 39.8 7.4 7.2e-10 38.8 7.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Spt20 PF12090.8 CCF33104.1 - 4.6 6.8 8.5 7.2 6.2 8.5 1.2 1 0 0 1 1 1 0 Spt20 family adh_short_C2 PF13561.6 CCF33106.1 - 1.9e-27 96.3 1.7 3.4e-27 95.5 1.7 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF33106.1 - 1.8e-20 73.2 0.9 2.4e-20 72.8 0.9 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF33106.1 - 3.6e-08 33.5 0.1 5.9e-08 32.8 0.1 1.3 1 0 0 1 1 1 1 KR domain ADH_zinc_N PF00107.26 CCF33106.1 - 0.0028 17.6 0.1 0.016 15.2 0.1 2.2 2 0 0 2 2 2 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 CCF33106.1 - 0.01 15.2 0.0 0.019 14.3 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain CTP_transf_3 PF02348.19 CCF33106.1 - 0.016 15.1 0.0 0.025 14.5 0.0 1.2 1 0 0 1 1 1 0 Cytidylyltransferase SUKH-4 PF14435.6 CCF33108.1 - 0.16 12.0 0.0 0.17 11.9 0.0 1.1 1 0 0 1 1 1 0 SUKH-4 immunity protein Aldo_ket_red PF00248.21 CCF33109.1 - 2e-55 188.1 0.0 2.6e-55 187.7 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Methyltransf_25 PF13649.6 CCF33111.1 - 1.2e-07 32.4 0.1 2.5e-07 31.3 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF33111.1 - 4.6e-05 24.0 0.1 8.3e-05 23.2 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ribosomal_S26e PF01283.19 CCF33112.1 - 4.9e-53 178.1 8.8 5.8e-53 177.9 8.8 1.0 1 0 0 1 1 1 1 Ribosomal protein S26e zf_CopZ PF18423.1 CCF33112.1 - 0.0074 16.2 0.3 0.055 13.4 0.0 2.1 2 0 0 2 2 2 1 Zinc binding domain DUF4668 PF15701.5 CCF33112.1 - 0.077 12.8 0.7 0.13 12.1 0.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4668) DUF1918 PF08940.11 CCF33112.1 - 0.16 11.7 0.1 0.28 10.8 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1918) Egh16-like PF11327.8 CCF33113.1 - 1.4e-48 165.8 8.0 1.6e-48 165.6 8.0 1.0 1 0 0 1 1 1 1 Egh16-like virulence factor Acetyltransf_1 PF00583.25 CCF33114.1 - 1.9e-19 70.0 0.0 2.4e-19 69.7 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CCF33114.1 - 1.5e-10 41.3 0.0 2.3e-10 40.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CCF33114.1 - 1.3e-08 34.9 0.0 1.9e-08 34.3 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 CCF33114.1 - 5.7e-07 30.3 0.0 6.9e-07 30.0 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 CCF33114.1 - 1.7e-06 28.1 0.0 3e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_4 PF13420.7 CCF33114.1 - 2.4e-06 27.8 0.0 4.4e-06 26.9 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CCF33114.1 - 1.1e-05 25.4 0.0 5.2e-05 23.1 0.0 2.0 3 0 0 3 3 3 1 FR47-like protein Acetyltransf_9 PF13527.7 CCF33114.1 - 2.9e-05 24.1 0.0 3.8e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.6 CCF33114.1 - 0.048 13.6 0.0 0.095 12.7 0.0 1.4 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase Acetyltransf_15 PF17013.5 CCF33114.1 - 0.066 12.7 0.0 0.082 12.4 0.0 1.1 1 0 0 1 1 1 0 Putative acetyl-transferase GNAT_acetyltr_2 PF13718.6 CCF33114.1 - 0.15 11.5 0.1 1.6 8.0 0.0 2.0 2 0 0 2 2 2 0 GNAT acetyltransferase 2 Stealth_CR1 PF17101.5 CCF33114.1 - 0.23 11.3 6.5 1.7 8.5 0.2 3.1 3 0 0 3 3 3 0 Stealth protein CR1, conserved region 1 ADH_zinc_N PF00107.26 CCF33116.1 - 3e-09 36.9 0.0 6.2e-09 35.9 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCF33116.1 - 3.4e-07 30.1 0.0 6.8e-07 29.2 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 CCF33116.1 - 7.6e-05 23.8 0.0 0.00018 22.6 0.0 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Epimerase PF01370.21 CCF33116.1 - 0.0015 18.0 0.0 0.0021 17.5 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Methyltransf_24 PF13578.6 CCF33117.1 - 2.2e-11 44.7 0.2 4.5e-11 43.7 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_3 PF01596.17 CCF33117.1 - 3.9e-08 32.7 0.0 7.1e-08 31.9 0.0 1.4 1 1 0 1 1 1 1 O-methyltransferase HhH-GPD PF00730.25 CCF33119.1 - 2.4e-09 37.6 0.0 8.1e-09 35.9 0.0 2.1 1 1 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 CCF33119.1 - 0.018 14.9 0.0 0.049 13.5 0.0 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix motif Sugar_tr PF00083.24 CCF33120.1 - 2.9e-61 207.7 15.1 3.5e-61 207.4 15.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF33120.1 - 9.2e-21 74.1 29.4 1.5e-18 66.9 11.8 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Pkinase PF00069.25 CCF33122.1 - 2.4e-17 63.2 0.0 1.8e-08 34.1 0.0 2.5 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCF33122.1 - 4.2e-07 29.5 0.0 0.00099 18.5 0.0 2.4 2 1 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 CCF33122.1 - 0.0039 16.6 0.1 0.18 11.1 0.0 2.5 3 0 0 3 3 3 1 Kinase-like APH PF01636.23 CCF33122.1 - 0.068 13.1 6.4 0.27 11.1 0.1 2.3 2 0 0 2 2 2 0 Phosphotransferase enzyme family Epimerase PF01370.21 CCF33124.1 - 9.4e-13 48.2 0.0 1.1e-12 47.9 0.0 1.0 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CCF33124.1 - 1.5e-11 43.8 0.0 2e-11 43.5 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 CCF33124.1 - 6.4e-09 36.0 0.2 8.2e-09 35.6 0.2 1.1 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 CCF33124.1 - 9.6e-09 35.1 0.0 1.1e-08 34.8 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 CCF33124.1 - 2.6e-06 26.8 0.1 0.0041 16.3 0.0 2.0 2 0 0 2 2 2 2 Male sterility protein NmrA PF05368.13 CCF33124.1 - 1.6e-05 24.6 0.2 2.5e-05 24.0 0.2 1.3 1 1 0 1 1 1 1 NmrA-like family adh_short PF00106.25 CCF33124.1 - 0.00028 20.4 0.0 0.00032 20.2 0.0 1.3 1 1 0 1 1 1 1 short chain dehydrogenase Polysacc_synt_2 PF02719.15 CCF33124.1 - 0.0026 17.0 0.0 0.0033 16.6 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Ank_4 PF13637.6 CCF33125.1 - 3e-12 46.8 0.1 2.9e-06 27.7 0.1 3.1 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 CCF33125.1 - 1.2e-11 45.1 0.0 1.5e-11 44.7 0.0 1.2 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 CCF33125.1 - 4.7e-11 42.6 0.2 1.9e-08 34.4 0.4 2.3 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 CCF33125.1 - 9.5e-11 41.7 0.2 4.3e-10 39.6 0.1 1.9 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCF33125.1 - 1.6e-09 37.2 0.0 1.5e-06 28.1 0.1 2.6 2 0 0 2 2 2 2 Ankyrin repeat p450 PF00067.22 CCF33128.1 - 1.4e-57 195.5 0.3 1.8e-57 195.1 0.3 1.1 1 0 0 1 1 1 1 Cytochrome P450 NmrA PF05368.13 CCF33129.1 - 4.2e-23 82.1 0.1 5.7e-23 81.7 0.1 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CCF33129.1 - 1.7e-16 60.6 0.0 2.4e-16 60.2 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CCF33129.1 - 0.00036 20.1 0.1 0.0027 17.2 0.1 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 CCF33129.1 - 0.00089 18.5 0.0 0.0014 17.8 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein Semialdhyde_dh PF01118.24 CCF33129.1 - 0.011 16.1 0.1 0.026 15.0 0.1 1.6 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 CCF33129.1 - 0.014 15.4 0.0 0.028 14.5 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase DapB_N PF01113.20 CCF33129.1 - 0.02 15.0 0.0 0.042 14.0 0.0 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus KR PF08659.10 CCF33129.1 - 0.021 14.8 0.0 0.036 14.0 0.0 1.3 1 0 0 1 1 1 0 KR domain 3Beta_HSD PF01073.19 CCF33129.1 - 0.031 13.3 0.0 0.14 11.2 0.0 1.9 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family FliG_C PF01706.16 CCF33129.1 - 0.039 14.1 0.0 0.11 12.7 0.0 1.7 1 0 0 1 1 1 0 FliG C-terminal domain Ank_2 PF12796.7 CCF33130.1 - 8.6e-43 144.8 0.3 3.3e-11 43.6 0.0 5.8 2 1 4 6 6 6 6 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CCF33130.1 - 7.7e-40 130.3 0.6 0.00091 19.5 0.0 11.7 13 0 0 13 13 13 9 Ankyrin repeat Ank_4 PF13637.6 CCF33130.1 - 5.1e-37 125.8 1.3 8.4e-08 32.6 0.0 8.5 4 2 3 8 8 8 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 CCF33130.1 - 2e-31 107.6 2.6 2.4e-05 24.5 0.0 8.2 6 2 3 9 9 9 8 Ankyrin repeats (many copies) Ank PF00023.30 CCF33130.1 - 1e-25 89.0 13.1 0.0015 18.9 0.0 11.0 10 1 1 11 11 11 7 Ankyrin repeat AAA PF00004.29 CCF33131.1 - 2.1e-38 131.7 0.1 3e-37 128.0 0.0 2.8 2 1 2 4 4 4 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CCF33131.1 - 4.7e-08 32.7 0.3 1.1e-07 31.5 0.3 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 CCF33131.1 - 2.9e-06 27.8 0.5 0.00027 21.4 0.3 3.2 2 1 1 3 3 3 1 AAA ATPase domain RuvB_N PF05496.12 CCF33131.1 - 1e-05 25.3 0.0 2.3e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 CCF33131.1 - 0.0002 21.6 0.5 0.088 13.1 0.1 3.2 1 1 1 2 2 2 1 AAA domain IstB_IS21 PF01695.17 CCF33131.1 - 0.00043 20.1 0.0 0.0015 18.3 0.0 1.9 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_33 PF13671.6 CCF33131.1 - 0.0012 19.0 0.2 0.015 15.4 0.3 2.8 2 1 0 2 2 2 1 AAA domain AAA_14 PF13173.6 CCF33131.1 - 0.002 18.2 0.0 0.0092 16.0 0.0 2.2 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 CCF33131.1 - 0.0031 17.1 0.0 1.3 8.5 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_18 PF13238.6 CCF33131.1 - 0.0073 16.9 0.0 0.063 13.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 CCF33131.1 - 0.013 15.5 0.1 0.038 14.0 0.1 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) TniB PF05621.11 CCF33131.1 - 0.014 14.8 0.0 0.81 9.1 0.0 2.4 1 1 1 2 2 2 0 Bacterial TniB protein MYCBPAP PF14646.6 CCF33131.1 - 0.017 14.1 0.0 0.028 13.4 0.0 1.3 1 0 0 1 1 1 0 MYCBP-associated protein family RNA_helicase PF00910.22 CCF33131.1 - 0.021 15.2 0.0 0.085 13.2 0.0 2.1 1 0 0 1 1 1 0 RNA helicase ATPase_2 PF01637.18 CCF33131.1 - 0.028 14.4 0.1 14 5.5 0.0 2.8 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea Hydin_ADK PF17213.3 CCF33131.1 - 0.037 14.3 0.9 5.4 7.2 0.0 3.2 3 0 0 3 3 3 0 Hydin Adenylate kinase-like domain AAA_24 PF13479.6 CCF33131.1 - 0.04 13.6 0.0 0.095 12.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 CCF33131.1 - 0.041 13.3 0.0 0.089 12.2 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI TIP49 PF06068.13 CCF33131.1 - 0.057 12.6 0.0 0.1 11.8 0.0 1.4 1 0 0 1 1 1 0 TIP49 P-loop domain NACHT PF05729.12 CCF33131.1 - 0.12 12.2 0.3 3 7.7 0.1 2.7 2 0 0 2 2 2 0 NACHT domain BSD PF03909.17 CCF33132.1 - 6.9e-30 102.8 0.8 1.3e-13 50.7 0.1 2.9 2 0 0 2 2 2 2 BSD domain PH_TFIIH PF08567.11 CCF33132.1 - 2.2e-26 92.0 0.3 6.3e-26 90.5 0.0 1.9 2 0 0 2 2 2 1 TFIIH p62 subunit, N-terminal domain FCH PF00611.23 CCF33134.1 - 1.1e-25 89.7 1.8 1.8e-25 89.0 0.1 2.4 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain C1_1 PF00130.22 CCF33134.1 - 1.6e-15 56.7 5.3 2.5e-15 56.1 5.3 1.3 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) SH3_9 PF14604.6 CCF33134.1 - 5.2e-05 23.0 0.1 0.0001 22.1 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 CCF33134.1 - 8.3e-05 22.1 0.0 0.00015 21.3 0.0 1.4 1 0 0 1 1 1 1 SH3 domain Allexi_40kDa PF05549.11 CCF33134.1 - 0.016 14.7 3.6 0.024 14.1 0.3 2.6 2 1 0 2 2 2 0 Allexivirus 40kDa protein SH3_3 PF08239.11 CCF33134.1 - 0.052 13.8 0.1 0.11 12.8 0.1 1.5 1 0 0 1 1 1 0 Bacterial SH3 domain C1_2 PF03107.16 CCF33134.1 - 0.059 13.7 5.9 0.11 12.9 5.9 1.4 1 0 0 1 1 1 0 C1 domain DUF4407 PF14362.6 CCF33134.1 - 0.067 12.5 11.9 0.52 9.6 0.3 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4407) FYVE PF01363.21 CCF33134.1 - 0.19 11.9 3.3 0.4 10.8 3.3 1.4 1 0 0 1 1 1 0 FYVE zinc finger DEAD PF00270.29 CCF33136.1 - 1e-34 119.8 0.0 2.4e-34 118.6 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF33136.1 - 1.7e-24 86.3 0.0 4.1e-24 85.1 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_30 PF13604.6 CCF33136.1 - 0.00027 20.7 0.0 0.0005 19.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 CCF33136.1 - 0.00036 20.6 0.0 0.00078 19.5 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 CCF33136.1 - 0.063 13.6 0.0 1 9.7 0.0 2.3 2 1 0 2 2 2 0 AAA domain AAA_22 PF13401.6 CCF33136.1 - 0.088 13.1 0.5 0.43 10.8 0.3 2.2 2 1 0 2 2 2 0 AAA domain Aspzincin_M35 PF14521.6 CCF33137.1 - 0.0014 19.2 2.9 0.0077 16.8 2.9 1.9 1 1 0 1 1 1 1 Lysine-specific metallo-endopeptidase AMP-binding PF00501.28 CCF33138.1 - 4.1e-87 292.5 0.0 1.1e-86 291.2 0.0 1.6 2 0 0 2 2 2 1 AMP-binding enzyme FtsX PF02687.21 CCF33138.1 - 3.3 8.3 10.9 0.26 11.8 2.2 2.6 2 0 0 2 2 2 0 FtsX-like permease family Ank_5 PF13857.6 CCF33140.1 - 2.1e-36 123.5 6.2 7.1e-09 35.8 0.0 5.6 1 1 5 6 6 6 6 Ankyrin repeats (many copies) Ank_2 PF12796.7 CCF33140.1 - 4e-35 120.3 2.9 9.1e-13 48.6 0.1 3.6 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CCF33140.1 - 1e-31 108.9 4.3 5.1e-09 36.5 0.1 5.1 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCF33140.1 - 8e-27 90.3 0.0 0.00029 21.1 0.0 6.2 6 0 0 6 6 6 6 Ankyrin repeat Ank PF00023.30 CCF33140.1 - 3.3e-21 74.7 1.5 3.3e-05 24.1 0.1 6.2 6 0 0 6 6 6 5 Ankyrin repeat TMF_DNA_bd PF12329.8 CCF33141.1 - 1.8e-14 53.5 2.7 1.8e-14 53.5 2.7 6.2 5 2 1 6 6 6 2 TATA element modulatory factor 1 DNA binding Tropomyosin_1 PF12718.7 CCF33141.1 - 0.001 19.2 9.0 0.001 19.2 9.0 4.3 2 1 1 4 4 4 2 Tropomyosin like Bacillus_HBL PF05791.11 CCF33141.1 - 5.7 6.7 16.1 3.2 7.5 2.1 3.3 3 0 0 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) Ceramidase PF05875.12 CCF33142.1 - 4e-98 328.1 13.0 4.5e-98 327.9 13.0 1.0 1 0 0 1 1 1 1 Ceramidase CDC50 PF03381.15 CCF33143.1 - 5e-103 344.5 0.3 6.1e-103 344.2 0.3 1.1 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family Asp4 PF16996.5 CCF33143.1 - 9.8 6.1 6.8 0.56 10.0 1.1 1.9 2 0 0 2 2 2 0 Accessory secretory protein Sec Asp4 FACT-Spt16_Nlob PF14826.6 CCF33144.1 - 2.4e-56 190.0 1.1 1.1e-55 187.9 1.1 2.2 1 0 0 1 1 1 1 FACT complex subunit SPT16 N-terminal lobe domain SPT16 PF08644.11 CCF33144.1 - 1.3e-55 187.7 0.1 1.3e-55 187.7 0.1 2.5 2 0 0 2 2 2 1 FACT complex subunit (SPT16/CDC68) Peptidase_M24 PF00557.24 CCF33144.1 - 8e-26 91.0 0.0 1.4e-25 90.3 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 Rtt106 PF08512.12 CCF33144.1 - 7.8e-16 58.3 1.1 2.2e-15 56.8 0.2 2.3 2 0 0 2 2 2 1 Histone chaperone Rttp106-like LysM PF01476.20 CCF33146.1 - 2.7e-12 46.5 0.0 1.1e-07 31.8 0.0 2.3 2 0 0 2 2 2 2 LysM domain Herpes_HEPA PF03324.14 CCF33147.1 - 0.09 13.3 0.0 0.16 12.4 0.0 1.4 1 0 0 1 1 1 0 Herpesvirus DNA helicase/primase complex associated protein KR PF08659.10 CCF33148.1 - 2.1e-28 99.5 0.2 4.4e-28 98.4 0.0 1.6 2 0 0 2 2 2 1 KR domain PP-binding PF00550.25 CCF33148.1 - 7e-09 35.9 0.0 4.4e-08 33.4 0.0 2.2 2 0 0 2 2 2 1 Phosphopantetheine attachment site Prefoldin_3 PF13758.6 CCF33149.1 - 2.4e-32 110.9 2.6 2.4e-32 110.9 2.6 2.1 2 0 0 2 2 2 1 Prefoldin subunit DUF3835 PF12927.7 CCF33149.1 - 2e-18 67.0 0.3 2e-18 67.0 0.3 4.0 4 0 0 4 4 4 1 Domain of unknown function (DUF3835) Prefoldin_2 PF01920.20 CCF33149.1 - 0.0047 16.9 14.8 0.032 14.2 0.3 4.6 4 0 0 4 4 4 1 Prefoldin subunit Prefoldin PF02996.17 CCF33149.1 - 0.005 16.7 2.0 0.32 10.9 0.2 2.6 2 0 0 2 2 2 1 Prefoldin subunit TRAF_BIRC3_bd PF16673.5 CCF33149.1 - 0.03 14.1 0.2 0.17 11.7 0.2 2.3 1 0 0 1 1 1 0 TNF receptor-associated factor BIRC3 binding domain Tropomyosin_1 PF12718.7 CCF33149.1 - 5 7.3 19.7 1.2 9.3 0.7 3.7 3 0 0 3 3 3 0 Tropomyosin like THOC7 PF05615.13 CCF33149.1 - 5.2 7.3 10.4 22 5.4 6.8 3.0 2 1 0 2 2 2 0 Tho complex subunit 7 CS PF04969.16 CCF33150.1 - 1.1e-17 64.7 0.2 1.1e-17 64.7 0.2 1.8 2 0 0 2 2 2 1 CS domain MAT1 PF06391.13 CCF33151.1 - 3.9e-35 121.5 5.8 4.7e-35 121.3 5.8 1.1 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 zf-C3HC4_5 PF17121.5 CCF33151.1 - 6e-30 102.9 10.1 9.6e-30 102.2 10.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CCF33151.1 - 0.0017 18.2 4.2 0.0042 16.9 4.3 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CCF33151.1 - 0.01 15.6 5.7 0.03 14.2 5.8 1.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) MRP-S26 PF14943.6 CCF33151.1 - 0.013 15.4 11.8 0.021 14.8 11.8 1.3 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 zf-RING_2 PF13639.6 CCF33151.1 - 0.075 13.4 6.1 0.13 12.6 6.1 1.5 1 0 0 1 1 1 0 Ring finger domain Zn_ribbon_17 PF17120.5 CCF33151.1 - 0.15 11.7 2.1 0.31 10.7 2.1 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_UBOX PF13445.6 CCF33151.1 - 0.85 9.7 5.7 1.5 8.9 5.7 1.4 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_5 PF14634.6 CCF33151.1 - 1.1 9.3 9.1 10 6.2 9.5 2.1 1 1 1 2 2 2 0 zinc-RING finger domain zf-RING_4 PF14570.6 CCF33151.1 - 1.2 9.0 10.3 26 4.7 11.3 2.2 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zf-UDP PF14569.6 CCF33151.1 - 1.3 9.2 5.4 4.5 7.5 5.4 1.8 1 1 0 1 1 1 0 Zinc-binding RING-finger nsp8 PF08717.10 CCF33151.1 - 2 8.3 6.2 1 9.2 3.8 1.7 2 0 0 2 2 2 0 nsp8 replicase FdhE PF04216.12 CCF33151.1 - 5.5 6.8 9.4 5.5 6.8 5.3 2.1 2 0 0 2 2 2 0 Protein involved in formate dehydrogenase formation ANTH PF07651.16 CCF33152.1 - 1.8e-67 227.3 0.5 2.4e-67 226.9 0.5 1.2 1 0 0 1 1 1 1 ANTH domain ENTH PF01417.20 CCF33152.1 - 2.7e-08 33.9 0.0 4.6e-08 33.2 0.0 1.3 1 0 0 1 1 1 1 ENTH domain DUF1720 PF08226.11 CCF33152.1 - 0.00057 20.2 47.8 0.00057 20.2 47.8 5.7 1 1 3 4 4 4 1 Domain of unknown function (DUF1720) Nsp2a_N PF17896.1 CCF33152.1 - 0.14 11.3 0.2 0.21 10.7 0.2 1.1 1 0 0 1 1 1 0 Replicase polyprotein 1a N-terminal domain tRNA-synt_2 PF00152.20 CCF33153.1 - 1.9e-85 286.7 0.0 3e-85 286.1 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA-synt_2b PF00587.25 CCF33153.1 - 0.082 12.9 0.0 0.11 12.4 0.0 1.5 1 1 0 1 1 1 0 tRNA synthetase class II core domain (G, H, P, S and T) Asn_synthase PF00733.21 CCF33154.1 - 9.1e-67 226.2 0.0 1.2e-66 225.8 0.0 1.1 1 0 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.6 CCF33154.1 - 4.4e-34 117.0 0.0 7.5e-34 116.3 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 CCF33154.1 - 2.1e-33 115.3 0.0 5e-33 114.1 0.0 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.8 CCF33154.1 - 0.00065 19.2 0.0 0.0012 18.4 0.0 1.4 1 0 0 1 1 1 1 Aluminium induced protein NAD_synthase PF02540.17 CCF33154.1 - 0.093 11.8 0.0 0.13 11.3 0.0 1.2 1 0 0 1 1 1 0 NAD synthase Sugar_tr PF00083.24 CCF33155.1 - 1.6e-92 310.8 24.9 1.9e-92 310.5 24.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF33155.1 - 6.1e-18 64.9 36.6 5.3e-14 51.9 9.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Spt20 PF12090.8 CCF33157.1 - 0.82 9.2 7.2 1.2 8.7 7.2 1.3 1 0 0 1 1 1 0 Spt20 family CPSF73-100_C PF11718.8 CCF33158.1 - 1.1e-83 280.1 0.0 1.6e-83 279.5 0.0 1.2 1 0 0 1 1 1 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Beta-Casp PF10996.8 CCF33158.1 - 8.8e-30 103.2 0.0 2.2e-29 101.9 0.0 1.7 2 0 0 2 2 2 1 Beta-Casp domain Lactamase_B PF00753.27 CCF33158.1 - 3e-18 66.6 0.6 6e-18 65.6 0.6 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_6 PF16661.5 CCF33158.1 - 3.5e-17 62.5 0.0 5.6e-17 61.8 0.0 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain RMMBL PF07521.12 CCF33158.1 - 6.8e-12 45.1 0.0 1.5e-11 44.1 0.0 1.5 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_3 PF13483.6 CCF33158.1 - 7.8e-06 25.9 0.0 2e-05 24.5 0.0 1.6 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_2 PF12706.7 CCF33158.1 - 1.7e-05 24.5 0.5 4.3e-05 23.1 0.5 1.6 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Beta_lactamase3 PF17030.5 CCF33158.1 - 0.11 11.7 0.0 0.19 11.0 0.0 1.2 1 0 0 1 1 1 0 Putative beta-lactamase-like family V_ATPase_I PF01496.19 CCF33159.1 - 0 1049.5 0.0 0 1049.4 0.0 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family CheZ PF04344.13 CCF33159.1 - 0.037 13.9 3.8 0.18 11.7 0.2 2.2 2 0 0 2 2 2 0 Chemotaxis phosphatase, CheZ SesA PF17107.5 CCF33159.1 - 0.053 13.7 1.7 0.97 9.6 0.1 2.9 3 0 0 3 3 3 0 N-terminal domain on NACHT_NTPase and P-loop NTPases DUF1515 PF07439.11 CCF33159.1 - 0.19 11.8 0.7 0.7 9.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1515) Laminin_II PF06009.12 CCF33159.1 - 0.27 11.3 4.2 7.3 6.6 0.1 2.3 2 0 0 2 2 2 0 Laminin Domain II BLOC1_2 PF10046.9 CCF33159.1 - 0.28 11.5 4.9 0.39 11.1 0.5 2.4 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Serine_rich PF08824.10 CCF33159.1 - 0.39 10.7 3.1 0.99 9.4 0.4 2.3 2 0 0 2 2 2 0 Serine rich protein interaction domain Nup54 PF13874.6 CCF33159.1 - 0.43 10.7 2.8 9.5 6.3 0.1 2.3 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 LXG PF04740.12 CCF33159.1 - 1.2 8.8 4.5 1.1 8.9 0.6 2.1 2 0 0 2 2 2 0 LXG domain of WXG superfamily Snapin_Pallidin PF14712.6 CCF33159.1 - 2.4 8.6 5.8 27 5.3 0.8 2.7 2 1 0 2 2 2 0 Snapin/Pallidin FAM184 PF15665.5 CCF33159.1 - 7.3 6.3 7.3 1.8 8.3 2.8 1.9 2 0 0 2 2 2 0 Family with sequence similarity 184, A and B HET PF06985.11 CCF33162.1 - 2.2e-35 122.2 0.8 3.5e-35 121.5 0.4 1.6 2 0 0 2 2 2 1 Heterokaryon incompatibility protein (HET) FAD_binding_3 PF01494.19 CCF33163.1 - 7.3e-16 58.4 1.1 4.2e-15 55.8 1.1 1.9 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CCF33163.1 - 1.2e-09 37.8 0.9 6.7e-05 22.3 0.7 2.2 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCF33163.1 - 3.3e-08 33.6 0.5 1.1e-07 32.0 0.1 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 CCF33163.1 - 2.2e-07 30.3 0.9 3.8e-07 29.6 0.9 1.4 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 CCF33163.1 - 4.9e-07 29.7 7.1 0.00068 19.3 3.3 2.7 3 0 0 3 3 3 2 FAD dependent oxidoreductase HI0933_like PF03486.14 CCF33163.1 - 3.7e-06 25.9 0.6 3.1e-05 22.9 0.6 2.0 1 1 0 1 1 1 1 HI0933-like protein Lycopene_cycl PF05834.12 CCF33163.1 - 1.7e-05 24.1 0.4 0.021 13.9 0.0 2.1 2 0 0 2 2 2 2 Lycopene cyclase protein Pyr_redox_3 PF13738.6 CCF33163.1 - 5.5e-05 22.6 0.6 0.00026 20.3 1.2 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 CCF33163.1 - 7.9e-05 22.2 0.1 9.4e-05 21.9 0.1 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Trp_halogenase PF04820.14 CCF33163.1 - 8.4e-05 21.6 0.3 0.00026 20.0 0.1 1.9 2 1 1 3 3 3 1 Tryptophan halogenase Pyr_redox PF00070.27 CCF33163.1 - 0.0003 21.3 0.3 0.002 18.6 0.4 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CCF33163.1 - 0.00044 19.6 0.3 0.00077 18.8 0.3 1.4 1 0 0 1 1 1 1 Thi4 family GIDA PF01134.22 CCF33163.1 - 0.0085 15.2 1.4 0.013 14.6 1.4 1.4 1 1 0 1 1 1 1 Glucose inhibited division protein A Amino_oxidase PF01593.24 CCF33163.1 - 0.014 14.7 0.1 0.78 8.9 0.0 2.3 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase FMO-like PF00743.19 CCF33163.1 - 0.025 13.0 0.4 0.036 12.5 0.4 1.1 1 0 0 1 1 1 0 Flavin-binding monooxygenase-like AlaDh_PNT_C PF01262.21 CCF33163.1 - 0.38 10.0 1.1 0.68 9.2 1.1 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain MFS_1 PF07690.16 CCF33164.1 - 4.5e-10 39.0 12.3 4.5e-10 39.0 12.3 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Vut_1 PF02592.15 CCF33164.1 - 0.017 15.4 1.1 0.017 15.4 1.1 2.1 2 1 0 2 2 2 0 Putative vitamin uptake transporter Oxidored-like PF09791.9 CCF33166.1 - 4.8e-25 87.0 3.4 4.8e-25 87.0 3.4 2.1 2 0 0 2 2 2 1 Oxidoreductase-like protein, N-terminal Wtap PF17098.5 CCF33166.1 - 0.021 14.7 0.0 0.035 14.0 0.0 1.3 1 0 0 1 1 1 0 WTAP/Mum2p family ESSS PF10183.9 CCF33166.1 - 0.085 13.1 0.1 0.16 12.2 0.1 1.4 1 0 0 1 1 1 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) Neisseria_TspB PF05616.13 CCF33166.1 - 4.6 5.6 9.2 38 2.6 0.0 2.0 2 0 0 2 2 2 0 Neisseria meningitidis TspB protein Siah-Interact_N PF09032.11 CCF33167.1 - 0.061 13.6 0.0 0.23 11.8 0.0 2.0 1 0 0 1 1 1 0 Siah interacting protein, N terminal Pyr_redox_2 PF07992.14 CCF33169.1 - 6.3e-53 179.9 0.1 8.3e-53 179.5 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCF33169.1 - 4.3e-12 46.4 0.0 1e-10 42.0 0.1 2.8 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCF33169.1 - 0.011 15.0 1.0 3.4 6.8 0.0 2.3 1 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase EcoR124_C PF12008.8 CCF33169.1 - 0.035 13.8 0.4 0.1 12.3 0.0 1.7 2 0 0 2 2 2 0 Type I restriction and modification enzyme - subunit R C terminal NAD_binding_7 PF13241.6 CCF33169.1 - 0.084 13.3 0.0 14 6.1 0.0 2.7 2 0 0 2 2 2 0 Putative NAD(P)-binding TPR_MLP1_2 PF07926.12 CCF33170.1 - 0.00012 22.2 49.8 0.0028 17.7 7.1 3.6 1 1 2 3 3 3 2 TPR/MLP1/MLP2-like protein Golgin_A5 PF09787.9 CCF33170.1 - 0.0066 16.0 51.5 0.06 12.8 12.1 3.2 1 1 2 3 3 3 3 Golgin subfamily A member 5 Leu_zip PF15294.6 CCF33170.1 - 0.14 11.6 43.6 0.38 10.2 1.2 3.7 1 1 2 3 3 3 0 Leucine zipper TraF_2 PF13729.6 CCF33170.1 - 9.2 5.5 8.0 2.5 7.4 3.4 2.1 2 1 0 2 2 2 0 F plasmid transfer operon, TraF, protein COesterase PF00135.28 CCF33172.1 - 2.2e-83 280.9 0.0 2.8e-83 280.5 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CCF33172.1 - 1.4e-07 31.6 0.2 1.2e-06 28.5 0.2 2.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CCF33172.1 - 0.00021 20.8 3.0 0.00058 19.4 3.1 1.5 1 1 0 1 1 1 1 Prolyl oligopeptidase family ACC_epsilon PF13822.6 CCF33173.1 - 2.2 9.0 6.0 0.22 12.2 1.3 1.7 2 0 0 2 2 2 0 Acyl-CoA carboxylase epsilon subunit p450 PF00067.22 CCF33174.1 - 5.3e-50 170.5 0.0 7.4e-50 170.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Dynamin_N PF00350.23 CCF33175.1 - 7.1e-16 58.7 0.0 2.6e-15 56.9 0.0 2.0 1 1 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 CCF33175.1 - 7.3e-08 32.5 0.3 6.2e-06 26.3 0.0 3.3 3 2 0 3 3 3 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CCF33175.1 - 1.2e-06 28.6 0.2 1.8e-05 24.7 0.0 2.9 3 0 0 3 3 3 1 RsgA GTPase AAA_16 PF13191.6 CCF33175.1 - 3.9e-06 27.4 0.1 2.2e-05 24.9 0.1 2.2 2 0 0 2 2 2 1 AAA ATPase domain ABC_tran PF00005.27 CCF33175.1 - 0.0003 21.3 0.0 0.0012 19.4 0.0 2.0 1 0 0 1 1 1 1 ABC transporter AAA_22 PF13401.6 CCF33175.1 - 0.0016 18.8 1.1 0.018 15.3 0.0 3.3 4 1 1 5 5 5 1 AAA domain Roc PF08477.13 CCF33175.1 - 0.0021 18.3 0.0 0.014 15.6 0.0 2.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AIG1 PF04548.16 CCF33175.1 - 0.024 14.0 0.0 0.12 11.7 0.0 2.2 3 0 0 3 3 3 0 AIG1 family AAA_18 PF13238.6 CCF33175.1 - 0.056 14.0 0.2 0.33 11.5 0.1 2.5 2 1 0 2 2 2 0 AAA domain Septin PF00735.18 CCF33175.1 - 0.087 12.1 0.0 0.16 11.2 0.0 1.4 1 0 0 1 1 1 0 Septin Ras PF00071.22 CCF33175.1 - 0.12 11.9 0.1 0.47 10.0 0.0 2.1 2 0 0 2 2 2 0 Ras family CUTL PF16557.5 CCF33175.1 - 1.6 8.9 3.3 32 4.8 0.1 3.7 3 0 0 3 3 3 0 CUT1-like DNA-binding domain of SATB DUF1629 PF07791.11 CCF33176.1 - 0.062 13.4 0.0 0.075 13.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1629) AAA_18 PF13238.6 CCF33177.1 - 6.1e-29 101.2 0.0 1e-28 100.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 CCF33177.1 - 5.4e-09 36.6 0.1 9.3e-08 32.6 0.0 2.3 1 1 1 2 2 2 1 AAA domain AAA_33 PF13671.6 CCF33177.1 - 9.4e-06 25.8 0.1 0.00074 19.7 0.1 2.3 1 1 0 1 1 1 1 AAA domain ADK PF00406.22 CCF33177.1 - 1.5e-05 25.2 0.0 0.0029 17.7 0.0 2.2 2 0 0 2 2 2 1 Adenylate kinase AAA PF00004.29 CCF33177.1 - 2.9e-05 24.5 0.0 0.0016 18.9 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 CCF33177.1 - 3.5e-05 24.1 0.1 0.00018 21.8 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 CCF33177.1 - 0.00057 20.3 0.3 0.0018 18.7 0.3 1.9 1 1 0 1 1 1 1 AAA ATPase domain NTPase_1 PF03266.15 CCF33177.1 - 0.0007 19.6 0.1 0.0014 18.6 0.0 1.6 2 0 0 2 2 2 1 NTPase Thymidylate_kin PF02223.17 CCF33177.1 - 0.001 18.8 0.1 0.85 9.3 0.0 2.1 2 0 0 2 2 2 2 Thymidylate kinase Hydin_ADK PF17213.3 CCF33177.1 - 0.0018 18.6 0.0 0.0032 17.8 0.0 1.4 1 0 0 1 1 1 1 Hydin Adenylate kinase-like domain AAA_22 PF13401.6 CCF33177.1 - 0.002 18.4 0.2 0.0076 16.5 0.0 1.9 2 0 0 2 2 2 1 AAA domain SKI PF01202.22 CCF33177.1 - 0.003 17.7 0.0 1.8 8.7 0.0 2.1 2 0 0 2 2 2 2 Shikimate kinase AAA_5 PF07728.14 CCF33177.1 - 0.0049 16.9 0.0 0.011 15.7 0.0 1.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) KTI12 PF08433.10 CCF33177.1 - 0.0057 16.1 0.0 0.012 15.1 0.0 1.6 2 0 0 2 2 2 1 Chromatin associated protein KTI12 dNK PF01712.19 CCF33177.1 - 0.015 15.2 0.3 2.6 7.9 0.1 2.1 1 1 1 2 2 2 0 Deoxynucleoside kinase Viral_helicase1 PF01443.18 CCF33177.1 - 0.019 14.7 0.0 0.03 14.1 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_30 PF13604.6 CCF33177.1 - 0.027 14.2 2.1 1.3 8.7 0.5 2.4 1 1 1 2 2 2 0 AAA domain Rad17 PF03215.15 CCF33177.1 - 0.028 14.3 0.1 0.065 13.2 0.0 1.6 2 0 0 2 2 1 0 Rad17 P-loop domain RNA_helicase PF00910.22 CCF33177.1 - 0.029 14.7 0.0 0.049 14.0 0.0 1.4 1 0 0 1 1 1 0 RNA helicase AAA_19 PF13245.6 CCF33177.1 - 0.031 14.6 0.1 0.2 12.0 0.1 2.0 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 CCF33177.1 - 0.036 13.8 0.0 0.096 12.4 0.0 1.8 2 0 0 2 2 2 0 AAA domain SRP54 PF00448.22 CCF33177.1 - 0.051 13.2 0.0 0.091 12.4 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_14 PF13173.6 CCF33177.1 - 0.066 13.2 0.0 0.16 12.0 0.0 1.7 2 0 0 2 2 2 0 AAA domain ATP_bind_1 PF03029.17 CCF33177.1 - 0.072 12.9 0.2 0.16 11.7 0.0 1.6 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_3 PF07726.11 CCF33177.1 - 0.087 12.7 0.1 0.22 11.4 0.0 1.6 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Cytidylate_kin2 PF13189.6 CCF33177.1 - 0.12 12.5 0.0 0.32 11.1 0.0 1.8 1 1 0 1 1 1 0 Cytidylate kinase-like family MeaB PF03308.16 CCF33177.1 - 0.14 11.1 0.1 0.23 10.4 0.1 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Ham1p_like PF01725.16 CCF33178.1 - 4.2e-57 193.1 0.0 4.7e-57 192.9 0.0 1.0 1 0 0 1 1 1 1 Ham1 family Peptidase_C78 PF07910.13 CCF33179.1 - 2.2e-49 167.8 0.0 3.1e-49 167.3 0.0 1.2 1 0 0 1 1 1 1 Peptidase family C78 zf-Di19 PF05605.12 CCF33179.1 - 0.0051 17.1 1.1 0.018 15.3 0.2 2.1 2 0 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.26 CCF33179.1 - 0.18 12.3 0.0 0.53 10.9 0.0 1.9 1 0 0 1 1 1 0 Zinc finger, C2H2 type Ras PF00071.22 CCF33180.1 - 3.6e-46 156.7 0.1 4.1e-46 156.5 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCF33180.1 - 3e-16 59.7 0.0 4.2e-16 59.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCF33180.1 - 2.5e-07 30.3 0.0 3.1e-07 30.0 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 CCF33180.1 - 3.7e-06 26.6 0.1 2.1e-05 24.1 0.0 1.8 1 1 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 CCF33180.1 - 0.00014 21.9 0.0 0.00022 21.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CCF33180.1 - 0.00034 20.6 0.0 0.06 13.2 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase SRPRB PF09439.10 CCF33180.1 - 0.00078 18.9 0.0 0.002 17.6 0.0 1.6 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_14 PF13173.6 CCF33180.1 - 0.014 15.4 0.0 0.023 14.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain PI-PLC-X PF00388.19 CCF33181.1 - 2.8e-58 195.6 0.0 4.5e-58 195.0 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 CCF33181.1 - 1.3e-40 138.3 0.1 3.2e-40 137.1 0.0 1.7 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, Y domain Cupin_2 PF07883.11 CCF33182.1 - 1.9e-05 24.3 0.6 2.4e-05 23.9 0.6 1.2 1 0 0 1 1 1 1 Cupin domain Cupin_7 PF12973.7 CCF33182.1 - 0.055 13.4 0.1 0.11 12.4 0.1 1.5 1 1 0 1 1 1 0 ChrR Cupin-like domain VHS PF00790.19 CCF33183.1 - 8e-46 155.4 0.2 3.4e-45 153.3 0.0 2.1 3 0 0 3 3 3 1 VHS domain GAT PF03127.14 CCF33183.1 - 4.5e-19 68.5 0.4 4.5e-19 68.5 0.4 2.3 3 0 0 3 3 3 1 GAT domain Alpha_adaptinC2 PF02883.20 CCF33183.1 - 9.6e-15 54.9 0.5 2.1e-14 53.8 0.0 1.8 2 0 0 2 2 2 1 Adaptin C-terminal domain GGA_N-GAT PF18308.1 CCF33183.1 - 4e-08 32.8 0.0 1.3e-07 31.1 0.0 1.9 1 0 0 1 1 1 1 GGA N-GAT domain Ribo_biogen_C PF04034.13 CCF33184.1 - 5.5e-50 168.4 0.0 7.4e-50 167.9 0.0 1.2 1 0 0 1 1 1 1 Ribosome biogenesis protein, C-terminal RLI PF04068.15 CCF33184.1 - 5.8e-11 42.0 1.1 5.8e-11 42.0 1.1 1.6 2 0 0 2 2 2 1 Possible Fer4-like domain in RNase L inhibitor, RLI BUD22 PF09073.10 CCF33184.1 - 9.3 5.5 23.0 14 4.8 23.0 1.3 1 0 0 1 1 1 0 BUD22 GTP_EFTU PF00009.27 CCF33185.1 - 5.7e-34 117.4 5.6 1.8e-32 112.4 5.6 2.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 CCF33185.1 - 1.3e-26 92.8 1.5 3.4e-26 91.4 1.5 1.8 1 0 0 1 1 1 1 Translation-initiation factor 2 MMR_HSR1 PF01926.23 CCF33185.1 - 1.6e-10 41.1 0.3 4.3e-10 39.7 0.3 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase IF2_N PF04760.15 CCF33185.1 - 1.9e-07 30.8 0.0 5.2e-07 29.4 0.0 1.9 1 0 0 1 1 1 1 Translation initiation factor IF-2, N-terminal region RsgA_GTPase PF03193.16 CCF33185.1 - 9.2e-07 28.9 0.7 6e-05 23.0 0.1 2.4 1 1 1 2 2 2 1 RsgA GTPase Arf PF00025.21 CCF33185.1 - 9.5e-05 21.9 0.0 0.00018 21.0 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 CCF33185.1 - 0.00015 21.2 0.4 0.00049 19.6 0.4 1.7 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU_D2 PF03144.25 CCF33185.1 - 0.00052 20.3 5.6 0.0025 18.2 0.9 3.2 3 0 0 3 3 3 1 Elongation factor Tu domain 2 Ras PF00071.22 CCF33185.1 - 0.00062 19.4 0.2 0.0011 18.6 0.2 1.4 1 0 0 1 1 1 1 Ras family FeoB_N PF02421.18 CCF33185.1 - 0.0013 18.3 0.2 0.0038 16.8 0.2 1.8 1 1 0 1 1 1 1 Ferrous iron transport protein B GTP_EFTU_D4 PF14578.6 CCF33185.1 - 0.0014 18.5 0.3 0.0014 18.5 0.3 2.4 2 0 0 2 2 2 1 Elongation factor Tu domain 4 Roc PF08477.13 CCF33185.1 - 0.0022 18.2 0.1 0.0044 17.2 0.1 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase PduV-EutP PF10662.9 CCF33185.1 - 0.021 14.5 0.4 0.056 13.2 0.4 1.7 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation MMR_HSR1_Xtn PF16897.5 CCF33185.1 - 0.27 11.3 1.3 0.56 10.2 0.1 2.0 2 0 0 2 2 2 0 C-terminal region of MMR_HSR1 domain Dynamin_N PF00350.23 CCF33185.1 - 8.9 6.3 7.8 11 6.0 0.0 3.6 3 1 1 4 4 4 0 Dynamin family PP28 PF10252.9 CCF33187.1 - 3.1e-27 94.8 18.4 3.1e-27 94.8 18.4 3.2 2 1 1 3 3 3 2 Casein kinase substrate phosphoprotein PP28 CoA_trans PF01144.23 CCF33190.1 - 4.6e-97 323.7 0.9 1.8e-59 200.7 0.0 2.0 2 0 0 2 2 2 2 Coenzyme A transferase DUF4330 PF14221.6 CCF33192.1 - 0.025 14.8 0.1 11 6.2 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4330) DUF2530 PF10745.9 CCF33192.1 - 2.4 8.4 5.3 1.9 8.8 0.1 3.1 3 1 0 3 3 3 0 Protein of unknown function (DUF2530) Smim3 PF17307.2 CCF33192.1 - 7.3 6.2 9.5 1.8 8.1 0.5 3.3 3 0 0 3 3 3 0 Small integral membrane protein 3 BNR PF02012.20 CCF33193.1 - 0.00017 21.1 1.2 0.82 9.9 0.0 3.7 3 0 0 3 3 3 2 BNR/Asp-box repeat BNR_2 PF13088.6 CCF33193.1 - 0.001 18.4 0.0 0.0018 17.7 0.0 1.5 1 0 0 1 1 1 1 BNR repeat-like domain Sortilin-Vps10 PF15902.5 CCF33193.1 - 0.14 10.9 0.3 6.9 5.3 0.0 2.3 2 1 0 2 2 2 0 Sortilin, neurotensin receptor 3, Glyco_hydro_35 PF01301.19 CCF33194.1 - 3.9e-87 292.8 0.3 5.7e-87 292.3 0.3 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 BetaGal_dom2 PF10435.9 CCF33194.1 - 1.7e-61 207.2 6.0 2.8e-61 206.5 6.0 1.3 1 0 0 1 1 1 1 Beta-galactosidase, domain 2 BetaGal_dom4_5 PF13364.6 CCF33194.1 - 1.3e-23 83.7 0.9 3.9e-23 82.2 0.9 1.9 1 0 0 1 1 1 1 Beta-galactosidase jelly roll domain BetaGal_dom3 PF13363.6 CCF33194.1 - 7.6e-21 73.5 0.1 2.5e-20 71.8 0.1 1.9 1 0 0 1 1 1 1 Beta-galactosidase, domain 3 SGL PF08450.12 CCF33196.1 - 0.00051 19.7 0.1 0.013 15.1 0.0 2.4 2 0 0 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region PD40 PF07676.12 CCF33196.1 - 0.36 10.8 1.4 1.9 8.5 0.0 2.9 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Dor1 PF04124.12 CCF33197.1 - 1.3e-56 191.8 0.3 6.8e-45 153.2 2.2 2.1 2 0 0 2 2 2 2 Dor1-like family BATS PF06968.13 CCF33197.1 - 0.022 14.9 0.1 0.087 13.0 0.0 2.0 2 0 0 2 2 2 0 Biotin and Thiamin Synthesis associated domain TRAM_LAG1_CLN8 PF03798.16 CCF33198.1 - 1.7e-49 168.3 15.3 1.7e-49 168.3 15.3 1.4 2 0 0 2 2 2 1 TLC domain SHD1 PF03983.12 CCF33199.1 - 2.5e-35 120.1 0.1 4.2e-35 119.4 0.1 1.4 1 0 0 1 1 1 1 SLA1 homology domain 1, SHD1 SH3_1 PF00018.28 CCF33199.1 - 2.6e-34 116.6 8.1 4e-13 48.7 0.2 4.2 4 0 0 4 4 4 3 SH3 domain SH3_9 PF14604.6 CCF33199.1 - 1.5e-33 114.4 10.9 1e-11 44.5 0.3 3.8 4 0 0 4 4 4 3 Variant SH3 domain SH3_2 PF07653.17 CCF33199.1 - 2.3e-24 84.8 0.2 2.9e-08 33.3 0.0 4.4 4 0 0 4 4 4 3 Variant SH3 domain DUF1720 PF08226.11 CCF33199.1 - 2.2e-05 24.8 46.5 2.8e-05 24.5 30.0 6.4 3 1 2 6 6 6 2 Domain of unknown function (DUF1720) SH3_3 PF08239.11 CCF33199.1 - 0.0011 19.2 6.6 0.032 14.5 1.0 3.3 3 0 0 3 3 3 1 Bacterial SH3 domain SAM_4 PF18017.1 CCF33199.1 - 0.0024 17.8 0.0 0.0053 16.7 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_10 PF17902.1 CCF33199.1 - 0.011 15.8 0.0 0.089 12.9 0.1 2.4 2 0 0 2 2 2 0 SH3 domain Lum_binding PF00677.17 CCF33200.1 - 3.2e-45 152.0 0.4 2.3e-22 78.8 0.1 2.1 2 0 0 2 2 2 2 Lumazine binding domain ERCC4 PF02732.15 CCF33201.1 - 2.2e-23 83.2 0.0 3.5e-23 82.5 0.0 1.3 1 0 0 1 1 1 1 ERCC4 domain DUF4373 PF14297.6 CCF33201.1 - 0.0033 18.2 0.7 0.012 16.4 0.3 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4373) HHH_8 PF14716.6 CCF33201.1 - 0.0056 17.0 0.0 0.013 15.9 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix domain HTH_27 PF13463.6 CCF33201.1 - 0.023 15.2 0.0 0.083 13.4 0.0 2.0 1 0 0 1 1 1 0 Winged helix DNA-binding domain PGM_PMM_I PF02878.16 CCF33202.1 - 6.8e-17 61.5 0.1 4.4e-07 29.7 0.0 2.8 1 1 2 3 3 3 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_IV PF00408.20 CCF33202.1 - 1e-10 41.6 0.3 3.8e-10 39.8 0.3 2.0 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_III PF02880.16 CCF33202.1 - 0.00062 20.0 0.0 0.0016 18.7 0.0 1.7 1 1 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 CCF33202.1 - 0.004 17.7 0.6 0.077 13.6 0.6 2.8 1 1 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II Sugar_tr PF00083.24 CCF33203.1 - 4.3e-82 276.4 21.1 5.6e-82 276.0 21.1 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF33203.1 - 1.8e-15 56.8 57.0 8.3e-14 51.3 27.1 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily YebO PF13974.6 CCF33203.1 - 0.15 12.2 0.0 0.35 11.0 0.0 1.6 1 0 0 1 1 1 0 YebO-like protein DUF2456 PF10445.9 CCF33203.1 - 4.6 7.4 8.7 5.9 7.0 0.6 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2456) FRQ PF09421.10 CCF33204.1 - 0 1493.6 52.7 0 1493.4 52.7 1.0 1 0 0 1 1 1 1 Frequency clock protein F_actin_bind PF08919.10 CCF33206.1 - 0.16 12.0 0.0 0.2 11.8 0.0 1.1 1 0 0 1 1 1 0 F-actin binding HOOK PF05622.12 CCF33207.1 - 1.2e-05 23.7 92.3 0.008 14.4 58.0 4.1 2 1 1 3 3 3 3 HOOK protein DUF3040 PF11239.8 CCF33207.1 - 0.42 10.9 2.1 5.2 7.4 1.0 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) Fez1 PF06818.15 CCF33207.1 - 6.7 7.1 74.1 0.44 11.0 23.6 4.4 1 1 2 3 3 3 0 Fez1 ADK_lid PF05191.14 CCF33208.1 - 2.4e-17 62.6 0.0 6.1e-17 61.3 0.0 1.7 2 0 0 2 2 2 1 Adenylate kinase, active site lid ADK PF00406.22 CCF33208.1 - 8e-12 45.5 0.0 1e-11 45.2 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase CN_hydrolase PF00795.22 CCF33209.1 - 5.5e-41 140.6 0.0 7.5e-41 140.2 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase AtuA PF07287.11 CCF33210.1 - 5e-126 420.2 0.1 6e-126 419.9 0.1 1.1 1 0 0 1 1 1 1 Acyclic terpene utilisation family protein AtuA Sugar_tr PF00083.24 CCF33211.1 - 9.9e-36 123.5 15.6 1.1e-19 70.7 0.1 2.0 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 CCF33211.1 - 1.6e-09 37.1 19.6 0.00014 20.9 0.4 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Condensation PF00668.20 CCF33212.1 - 4.3e-118 394.9 0.0 8.6e-85 285.1 0.0 2.2 2 0 0 2 2 2 2 Condensation domain AMP-binding PF00501.28 CCF33212.1 - 2.7e-74 250.3 0.0 4.4e-74 249.6 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.25 CCF33212.1 - 1.1e-25 89.7 0.3 8.7e-12 45.2 0.0 2.8 2 0 0 2 2 2 2 Phosphopantetheine attachment site AMP-binding_C PF13193.6 CCF33212.1 - 2e-08 35.1 0.2 0.011 16.6 0.1 3.0 2 0 0 2 2 2 2 AMP-binding enzyme C-terminal domain Methyltransf_23 PF13489.6 CCF33212.1 - 0.00045 20.1 0.0 0.0085 15.9 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF33212.1 - 0.00058 20.5 0.0 0.01 16.4 0.0 2.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF33212.1 - 0.00059 20.5 0.0 0.0036 18.0 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF33212.1 - 0.0029 18.3 0.0 0.008 16.9 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Acetyltransf_1 PF00583.25 CCF33213.1 - 4.4e-15 55.9 0.1 5.8e-15 55.5 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CCF33213.1 - 3.9e-11 43.2 0.0 6.4e-11 42.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CCF33213.1 - 3.9e-10 39.7 0.0 5.4e-10 39.3 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 CCF33213.1 - 8.7e-05 22.7 0.0 8.7e-05 22.7 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CCF33213.1 - 0.00015 21.6 0.0 0.00026 20.9 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.7 CCF33213.1 - 0.0011 19.7 0.0 0.0014 19.3 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 CCF33213.1 - 0.0098 16.0 0.0 0.017 15.3 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Aminotran_4 PF01063.19 CCF33214.1 - 3.9e-11 43.2 0.0 9e-11 42.1 0.0 1.5 1 1 0 2 2 2 1 Amino-transferase class IV PSII_BNR PF14870.6 CCF33216.1 - 9.8e-10 38.2 1.0 8.2e-06 25.3 0.1 3.4 3 1 1 4 4 4 2 Photosynthesis system II assembly factor YCF48 Sortilin-Vps10 PF15902.5 CCF33216.1 - 2.4e-08 33.2 0.0 1.2e-05 24.3 0.0 2.6 2 1 1 3 3 3 2 Sortilin, neurotensin receptor 3, BNR PF02012.20 CCF33216.1 - 1.4e-05 24.4 20.7 0.25 11.5 0.3 5.9 5 0 0 5 5 5 3 BNR/Asp-box repeat Mo-co_dimer PF03404.16 CCF33216.1 - 0.038 14.0 5.1 13 5.8 0.0 4.5 5 0 0 5 5 5 0 Mo-co oxidoreductase dimerisation domain BNR_2 PF13088.6 CCF33216.1 - 0.2 10.9 4.3 1.4 8.2 0.3 3.0 2 1 2 4 4 4 0 BNR repeat-like domain FeS PF04060.13 CCF33219.1 - 0.044 13.4 0.6 0.092 12.4 0.6 1.5 1 0 0 1 1 1 0 Putative Fe-S cluster zf-C3HC4 PF00097.25 CCF33219.1 - 0.075 12.9 8.1 0.2 11.5 8.1 1.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CCF33219.1 - 0.17 11.8 7.2 0.35 10.8 7.2 1.6 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Rdx PF10262.9 CCF33219.1 - 0.31 11.3 1.4 49 4.2 0.0 3.5 3 1 0 3 3 3 0 Rdx family zf-RING_5 PF14634.6 CCF33219.1 - 0.32 11.0 6.8 0.54 10.3 6.8 1.4 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_4 PF15227.6 CCF33219.1 - 0.35 11.1 6.2 0.11 12.7 2.5 2.0 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING HSP70 PF00012.20 CCF33220.1 - 0.0012 17.2 0.0 0.013 13.7 0.0 2.0 2 0 0 2 2 2 1 Hsp70 protein BRF1 PF07741.13 CCF33220.1 - 0.018 15.3 1.1 0.033 14.5 1.1 1.4 1 0 0 1 1 1 0 Brf1-like TBP-binding domain Imm9 PF15587.6 CCF33220.1 - 0.081 12.6 0.0 0.17 11.5 0.0 1.5 1 0 0 1 1 1 0 Immunity protein 9 ADIP PF11559.8 CCF33221.1 - 0.00011 22.4 12.6 0.00017 21.7 12.6 1.3 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding GIT_CC PF16559.5 CCF33221.1 - 0.00041 20.2 4.2 0.00075 19.3 1.8 2.4 1 1 0 2 2 2 1 GIT coiled-coil Rho guanine nucleotide exchange factor HMMR_N PF15905.5 CCF33221.1 - 0.00082 18.9 12.0 0.0016 18.0 12.0 1.4 1 0 0 1 1 1 1 Hyaluronan mediated motility receptor N-terminal CENP-F_leu_zip PF10473.9 CCF33221.1 - 0.0031 17.6 6.3 0.0031 17.6 6.3 2.7 2 1 1 3 3 2 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GAS PF13851.6 CCF33221.1 - 0.0061 15.9 10.6 0.011 15.1 10.6 1.4 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding Filament PF00038.21 CCF33221.1 - 0.0074 15.9 11.0 0.0074 15.9 11.0 1.9 1 1 1 2 2 2 2 Intermediate filament protein DUF1664 PF07889.12 CCF33221.1 - 0.0096 16.0 8.0 0.012 15.6 3.5 2.5 1 1 1 2 2 2 1 Protein of unknown function (DUF1664) Leu_zip PF15294.6 CCF33221.1 - 0.012 15.1 11.3 0.026 14.1 11.3 1.4 1 0 0 1 1 1 0 Leucine zipper Jnk-SapK_ap_N PF09744.9 CCF33221.1 - 0.017 15.4 9.0 0.017 15.4 9.0 2.5 2 1 1 3 3 2 0 JNK_SAPK-associated protein-1 CCDC144C PF14915.6 CCF33221.1 - 0.018 14.2 12.0 0.043 12.9 12.0 1.6 1 0 0 1 1 1 0 CCDC144C protein coiled-coil region Laminin_I PF06008.14 CCF33221.1 - 0.026 14.3 8.4 0.048 13.4 8.4 1.4 1 0 0 1 1 1 0 Laminin Domain I Ax_dynein_light PF10211.9 CCF33221.1 - 0.045 13.7 13.8 0.14 12.1 13.8 1.7 1 1 0 1 1 1 0 Axonemal dynein light chain SHE3 PF17078.5 CCF33221.1 - 0.064 13.0 8.4 0.15 11.8 8.4 1.6 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 Rootletin PF15035.6 CCF33221.1 - 0.064 13.3 11.3 0.31 11.0 8.8 2.3 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion SlyX PF04102.12 CCF33221.1 - 0.11 13.2 9.6 0.54 10.9 0.3 3.4 3 0 0 3 3 3 0 SlyX Spc7 PF08317.11 CCF33221.1 - 0.13 11.2 10.8 0.24 10.2 10.8 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein Tropomyosin_1 PF12718.7 CCF33221.1 - 0.15 12.2 15.2 1.4 9.0 7.3 2.5 1 1 1 2 2 2 0 Tropomyosin like Laminin_II PF06009.12 CCF33221.1 - 0.15 12.1 10.6 0.08 13.0 5.4 2.3 1 1 1 2 2 2 0 Laminin Domain II UPF0242 PF06785.11 CCF33221.1 - 0.15 12.1 15.7 0.61 10.2 15.7 1.8 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DHR10 PF18595.1 CCF33221.1 - 0.17 11.9 15.5 0.33 11.0 13.3 2.4 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain bZIP_2 PF07716.15 CCF33221.1 - 0.18 11.9 15.6 0.62 10.2 2.8 4.3 3 1 1 4 4 4 0 Basic region leucine zipper Syntaxin-6_N PF09177.11 CCF33221.1 - 0.19 12.3 4.7 0.46 11.1 4.7 1.7 1 0 0 1 1 1 0 Syntaxin 6, N-terminal DUF4200 PF13863.6 CCF33221.1 - 0.2 12.1 16.2 0.38 11.2 15.8 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) DUF2951 PF11166.8 CCF33221.1 - 0.22 11.8 3.0 0.52 10.6 3.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2951) KASH_CCD PF14662.6 CCF33221.1 - 0.24 11.2 14.8 0.11 12.3 7.9 2.7 2 1 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH Fez1 PF06818.15 CCF33221.1 - 0.26 11.7 11.8 0.61 10.5 11.8 1.7 1 0 0 1 1 1 0 Fez1 Mto2_bdg PF12808.7 CCF33221.1 - 0.27 11.6 10.6 0.83 10.0 0.7 3.5 2 1 1 3 3 3 0 Micro-tubular organiser Mto1 C-term Mto2-binding region Golgin_A5 PF09787.9 CCF33221.1 - 0.29 10.5 12.7 0.5 9.8 12.7 1.3 1 0 0 1 1 1 0 Golgin subfamily A member 5 YabA PF06156.13 CCF33221.1 - 0.32 11.7 10.4 2.2 9.0 5.9 3.2 2 1 1 3 3 2 0 Initiation control protein YabA Herpes_BLRF2 PF05812.12 CCF33221.1 - 0.35 11.0 7.9 13 5.9 1.6 3.5 1 1 2 3 3 3 0 Herpesvirus BLRF2 protein AAA_13 PF13166.6 CCF33221.1 - 0.41 9.2 10.3 0.7 8.5 10.3 1.3 1 0 0 1 1 1 0 AAA domain Med9 PF07544.13 CCF33221.1 - 0.42 10.7 12.6 0.58 10.3 0.6 3.2 1 1 2 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 TRAF_BIRC3_bd PF16673.5 CCF33221.1 - 0.48 10.2 9.9 2.2 8.1 2.7 2.6 2 0 0 2 2 2 0 TNF receptor-associated factor BIRC3 binding domain BLOC1_2 PF10046.9 CCF33221.1 - 0.5 10.7 10.5 1.5 9.2 3.8 2.5 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 FlaC_arch PF05377.11 CCF33221.1 - 0.59 10.6 8.7 0.86 10.0 2.4 3.3 1 1 3 4 4 4 0 Flagella accessory protein C (FlaC) Csm1_N PF18504.1 CCF33221.1 - 0.66 10.4 13.5 1.7 9.1 4.3 3.4 1 1 2 3 3 3 0 Csm1 N-terminal domain NPV_P10 PF05531.12 CCF33221.1 - 0.7 10.4 3.3 8.8 6.9 0.2 3.0 2 1 1 3 3 2 0 Nucleopolyhedrovirus P10 protein GTP-bdg_M PF16360.5 CCF33221.1 - 0.81 10.3 9.0 2.1 9.0 0.8 2.4 1 1 1 2 2 2 0 GTP-binding GTPase Middle Region ABC_tran_CTD PF16326.5 CCF33221.1 - 0.91 9.8 9.2 2.8 8.2 0.1 3.1 1 1 2 3 3 3 0 ABC transporter C-terminal domain TSC22 PF01166.18 CCF33221.1 - 1 9.7 6.2 41 4.6 0.1 4.3 4 1 1 5 5 4 0 TSC-22/dip/bun family V_ATPase_I PF01496.19 CCF33221.1 - 1.1 7.1 6.2 1.4 6.8 6.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family YscO PF07321.12 CCF33221.1 - 1.1 9.2 14.2 2.1 8.3 14.2 1.4 1 0 0 1 1 1 0 Type III secretion protein YscO Cnn_1N PF07989.11 CCF33221.1 - 1.2 9.4 10.1 17 5.6 10.1 2.7 1 1 0 1 1 1 0 Centrosomin N-terminal motif 1 Fzo_mitofusin PF04799.13 CCF33221.1 - 1.2 8.7 8.9 0.91 9.1 0.5 2.3 1 1 1 2 2 2 0 fzo-like conserved region FliS_cochap PF16522.5 CCF33221.1 - 1.2 9.0 7.8 0.45 10.5 1.1 2.4 2 0 0 2 2 2 0 Flagellar FLiS export co-chaperone, HP1076 Uso1_p115_C PF04871.13 CCF33221.1 - 1.3 9.4 14.5 1 9.7 10.2 2.3 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Atg14 PF10186.9 CCF33221.1 - 1.5 7.9 11.2 2.2 7.3 11.2 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 XhlA PF10779.9 CCF33221.1 - 1.6 9.0 7.3 4.4 7.6 1.8 2.9 2 1 1 3 3 2 0 Haemolysin XhlA DUF3450 PF11932.8 CCF33221.1 - 2 7.7 13.2 4.3 6.6 7.7 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Phage_GP20 PF06810.11 CCF33221.1 - 2 8.2 12.8 5.1 6.9 9.7 2.4 1 1 1 2 2 2 0 Phage minor structural protein GP20 CENP-H PF05837.12 CCF33221.1 - 2.2 8.7 13.4 1 9.8 7.6 2.6 1 1 1 2 2 2 0 Centromere protein H (CENP-H) Prefoldin_2 PF01920.20 CCF33221.1 - 3 7.9 14.0 1.1e+03 -0.4 14.0 2.8 1 1 0 1 1 1 0 Prefoldin subunit ATG16 PF08614.11 CCF33221.1 - 3.3 7.9 13.3 15 5.8 13.3 2.0 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) HIP1_clath_bdg PF16515.5 CCF33221.1 - 3.4 8.3 13.0 2.9 8.6 4.6 2.5 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Cep57_CLD_2 PF14197.6 CCF33221.1 - 3.7 7.7 10.8 15 5.8 2.8 3.4 2 1 1 3 3 3 0 Centrosome localisation domain of PPC89 TPR_MLP1_2 PF07926.12 CCF33221.1 - 3.9 7.5 17.6 0.72 9.9 9.7 2.4 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein bZIP_1 PF00170.21 CCF33221.1 - 4.3 7.5 12.4 85 3.4 8.3 3.6 2 1 0 2 2 2 0 bZIP transcription factor Shugoshin_N PF07558.11 CCF33221.1 - 5.1 7.0 6.3 2.1 8.3 0.1 3.3 4 0 0 4 4 2 0 Shugoshin N-terminal coiled-coil region DivIC PF04977.15 CCF33221.1 - 5.2 6.9 16.0 1.5 8.6 1.8 3.6 1 1 3 4 4 4 0 Septum formation initiator APG6_N PF17675.1 CCF33221.1 - 5.4 7.6 13.1 15 6.1 13.1 1.8 1 1 0 1 1 1 0 Apg6 coiled-coil region DUF2968 PF11180.8 CCF33221.1 - 6.1 6.4 13.9 0.21 11.2 7.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2968) Syntaxin_2 PF14523.6 CCF33221.1 - 6.9 7.1 11.1 9.1 6.7 4.0 2.6 1 1 1 2 2 2 0 Syntaxin-like protein ZapB PF06005.12 CCF33221.1 - 8.7 6.9 16.1 1.8e+02 2.7 1.1 3.2 1 1 2 3 3 3 0 Cell division protein ZapB DUF16 PF01519.16 CCF33221.1 - 9.8 6.7 14.8 9.8 6.7 2.3 3.2 1 1 2 3 3 3 0 Protein of unknown function DUF16 Aminotran_1_2 PF00155.21 CCF33222.1 - 5e-35 121.3 0.0 6.7e-35 120.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 CCF33222.1 - 1.1e-05 24.4 0.0 1.4e-05 24.0 0.0 1.1 1 0 0 1 1 1 1 Alanine-glyoxylate amino-transferase Beta_elim_lyase PF01212.21 CCF33222.1 - 0.00028 20.3 0.0 0.00045 19.6 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.20 CCF33222.1 - 0.0004 19.0 0.0 0.0006 18.5 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 CCF33222.1 - 0.0079 15.2 0.0 0.013 14.5 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V Alliinase_C PF04864.13 CCF33222.1 - 0.066 12.1 0.5 0.15 10.9 0.5 1.6 1 1 0 1 1 1 0 Allinase CR6_interact PF10147.9 CCF33223.1 - 0.0026 17.5 1.9 0.0054 16.5 1.9 1.6 1 0 0 1 1 1 1 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 ODV-E18 PF10717.9 CCF33223.1 - 0.0074 16.1 0.0 0.017 15.0 0.0 1.6 1 0 0 1 1 1 1 Occlusion-derived virus envelope protein ODV-E18 DUF2076 PF09849.9 CCF33223.1 - 0.017 15.2 1.3 0.017 15.2 1.3 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) RCR PF12273.8 CCF33223.1 - 0.03 15.0 0.2 0.03 15.0 0.2 3.2 2 2 0 2 2 2 0 Chitin synthesis regulation, resistance to Congo red HNH_2 PF13391.6 CCF33224.1 - 5.1e-13 48.9 0.0 1.3e-12 47.7 0.0 1.7 1 0 0 1 1 1 1 HNH endonuclease Fungal_trans PF04082.18 CCF33225.1 - 9.9e-06 24.8 0.0 1.9e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain PS-DH PF14765.6 CCF33226.1 - 1.8e-70 237.5 0.7 2.5e-70 237.1 0.0 1.6 2 0 0 2 2 2 1 Polyketide synthase dehydratase ketoacyl-synt PF00109.26 CCF33226.1 - 1.8e-70 237.4 0.0 3.5e-70 236.5 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 CCF33226.1 - 4.9e-56 189.5 0.0 1.4e-55 188.0 0.0 1.8 2 0 0 2 2 2 1 KR domain Acyl_transf_1 PF00698.21 CCF33226.1 - 1.4e-51 175.9 0.2 2.9e-51 174.9 0.2 1.5 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 CCF33226.1 - 3.2e-30 104.5 0.1 1.1e-29 102.8 0.1 2.0 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 CCF33226.1 - 3.4e-18 66.1 0.0 7.9e-18 65.0 0.0 1.6 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension adh_short PF00106.25 CCF33226.1 - 2.4e-05 23.9 0.0 6.1e-05 22.6 0.0 1.7 1 0 0 1 1 1 1 short chain dehydrogenase ADH_N PF08240.12 CCF33226.1 - 0.00041 20.2 0.0 0.00097 19.0 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Thiolase_N PF00108.23 CCF33226.1 - 0.0012 18.3 0.2 0.0027 17.1 0.2 1.5 1 0 0 1 1 1 1 Thiolase, N-terminal domain PP-binding PF00550.25 CCF33226.1 - 0.0045 17.3 1.4 0.0073 16.6 0.2 2.1 2 0 0 2 2 1 1 Phosphopantetheine attachment site ACP_syn_III PF08545.10 CCF33226.1 - 0.0051 16.6 0.6 0.018 14.9 0.6 2.0 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Pyr_redox_3 PF13738.6 CCF33227.1 - 2.5e-13 50.0 0.0 2.3e-10 40.3 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 CCF33227.1 - 1.4e-11 43.6 0.0 3.3e-06 25.8 0.0 2.4 3 0 0 3 3 3 2 Flavin-binding monooxygenase-like NAD_binding_9 PF13454.6 CCF33227.1 - 1e-07 32.1 0.0 4e-05 23.7 0.0 3.8 3 1 0 3 3 3 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 CCF33227.1 - 4.3e-06 26.2 0.0 0.0019 17.5 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CCF33227.1 - 8.1e-06 25.2 0.0 3.8e-05 23.0 0.0 2.0 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.14 CCF33227.1 - 0.00036 19.4 0.0 0.65 8.6 0.0 2.3 2 0 0 2 2 2 2 HI0933-like protein Thi4 PF01946.17 CCF33227.1 - 0.0054 16.0 0.3 0.0092 15.2 0.0 1.5 2 0 0 2 2 2 1 Thi4 family NAD_binding_8 PF13450.6 CCF33227.1 - 0.039 14.2 0.0 0.11 12.8 0.0 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 CCF33227.1 - 0.04 13.0 0.0 0.24 10.4 0.0 2.2 3 0 0 3 3 3 0 Lycopene cyclase protein DAO PF01266.24 CCF33227.1 - 0.057 13.0 0.0 19 4.7 0.1 3.2 3 0 0 3 3 3 0 FAD dependent oxidoreductase FAD_oxidored PF12831.7 CCF33227.1 - 0.18 11.1 0.0 0.39 10.0 0.0 1.6 2 0 0 2 2 2 0 FAD dependent oxidoreductase GIDA PF01134.22 CCF33227.1 - 0.27 10.3 0.2 2.8 6.9 0.0 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A MFS_1 PF07690.16 CCF33228.1 - 2.5e-35 122.1 51.3 2.5e-35 122.1 51.3 2.4 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF33228.1 - 1.6e-07 30.6 12.4 1.6e-07 30.6 12.4 3.5 3 1 0 3 3 3 2 Sugar (and other) transporter OATP PF03137.20 CCF33228.1 - 0.0055 15.1 1.9 0.0055 15.1 1.9 2.6 2 1 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family Homeobox_KN PF05920.11 CCF33229.1 - 4.1e-16 58.6 1.4 4.1e-16 58.6 1.4 3.6 4 0 0 4 4 4 1 Homeobox KN domain HTH_Tnp_Tc5 PF03221.16 CCF33229.1 - 7.3e-13 48.4 1.9 0.0002 21.3 0.1 4.8 4 1 0 4 4 4 2 Tc5 transposase DNA-binding domain Homeodomain PF00046.29 CCF33229.1 - 6.2e-06 26.0 0.6 2.1e-05 24.3 0.6 1.9 1 0 0 1 1 1 1 Homeodomain zf-C2H2_4 PF13894.6 CCF33229.1 - 0.0035 18.0 3.8 0.0035 18.0 3.8 5.5 6 0 0 6 6 6 1 C2H2-type zinc finger zf-C2H2 PF00096.26 CCF33229.1 - 0.14 12.7 26.6 0.044 14.2 3.9 4.5 4 0 0 4 4 4 0 Zinc finger, C2H2 type Zn_clus PF00172.18 CCF33229.1 - 0.29 11.3 2.5 0.86 9.8 2.5 1.8 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF3425 PF11905.8 CCF33230.1 - 4.1e-13 49.4 0.7 1e-12 48.1 0.7 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF3425) SNase PF00565.17 CCF33231.1 - 4.7e-75 249.0 0.7 2.4e-21 76.2 0.0 5.4 5 0 0 5 5 5 5 Staphylococcal nuclease homologue TUDOR PF00567.24 CCF33231.1 - 6.7e-24 84.2 0.0 1.3e-23 83.4 0.0 1.4 1 0 0 1 1 1 1 Tudor domain SMN PF06003.12 CCF33231.1 - 1.2e-05 24.7 0.0 3.1e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 Survival motor neuron protein (SMN) RNA_pol_Rpb1_3 PF04983.18 CCF33231.1 - 0.085 12.8 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 3 Sod_Cu PF00080.20 CCF33232.1 - 1e-45 155.4 7.3 1.2e-45 155.2 7.3 1.0 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) Glyco_hydro_71 PF03659.14 CCF33234.1 - 7.4e-144 479.2 5.2 1.2e-143 478.5 5.2 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 71 LysM PF01476.20 CCF33235.1 - 3.6e-07 30.2 0.0 0.041 13.9 0.0 2.6 2 0 0 2 2 2 2 LysM domain KR PF08659.10 CCF33236.1 - 1.7e-57 194.3 0.0 2.4e-57 193.7 0.0 1.3 1 0 0 1 1 1 1 KR domain ADH_zinc_N_2 PF13602.6 CCF33236.1 - 1.6e-16 61.5 0.0 3.8e-16 60.4 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 CCF33236.1 - 3e-09 36.9 0.3 1.6e-08 34.6 0.0 2.2 2 0 0 2 2 2 1 Zinc-binding dehydrogenase PP-binding PF00550.25 CCF33236.1 - 2.5e-07 30.9 0.1 5.7e-07 29.8 0.1 1.5 1 0 0 1 1 1 1 Phosphopantetheine attachment site adh_short PF00106.25 CCF33236.1 - 5.6e-06 25.9 0.0 3e-05 23.6 0.0 1.9 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF33236.1 - 0.0052 16.4 0.0 0.011 15.3 0.0 1.5 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Arginase PF00491.21 CCF33237.1 - 3.2e-19 69.5 0.1 3.4e-19 69.4 0.1 1.0 1 0 0 1 1 1 1 Arginase family Acetyltransf_17 PF17668.1 CCF33238.1 - 0.00094 20.0 0.0 0.0029 18.4 0.0 1.9 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain CFEM PF05730.11 CCF33239.1 - 4.3e-05 23.5 7.6 7e-05 22.8 7.6 1.3 1 0 0 1 1 1 1 CFEM domain PHO4 PF01384.20 CCF33239.1 - 0.25 10.4 5.0 0.3 10.1 5.0 1.2 1 0 0 1 1 1 0 Phosphate transporter family HAD_2 PF13419.6 CCF33240.1 - 2.1e-20 73.5 0.0 4.1e-20 72.6 0.0 1.5 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CCF33240.1 - 8.1e-08 32.8 0.0 9.3e-06 26.1 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CCF33240.1 - 1.9e-05 24.6 0.0 3.5e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like NB-ARC PF00931.22 CCF33241.1 - 1.5e-07 30.9 0.0 9e-07 28.3 0.0 2.1 1 1 0 1 1 1 1 NB-ARC domain AAA_22 PF13401.6 CCF33241.1 - 0.00042 20.6 0.0 0.042 14.1 0.0 2.6 2 0 0 2 2 2 1 AAA domain TPR_12 PF13424.6 CCF33241.1 - 0.00091 19.5 0.8 3.7 7.9 0.3 3.8 3 1 1 4 4 4 1 Tetratricopeptide repeat Abhydrolase_6 PF12697.7 CCF33241.1 - 0.001 19.7 0.0 0.006 17.2 0.0 2.3 2 0 0 2 2 2 1 Alpha/beta hydrolase family AAA_16 PF13191.6 CCF33241.1 - 0.0012 19.3 0.0 0.0047 17.3 0.0 2.2 1 0 0 1 1 1 1 AAA ATPase domain DUF676 PF05057.14 CCF33241.1 - 0.0064 16.0 0.0 0.012 15.1 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.13 CCF33241.1 - 0.043 13.5 0.0 0.12 12.1 0.0 1.7 2 0 0 2 2 2 0 PGAP1-like protein TPR_2 PF07719.17 CCF33241.1 - 0.25 11.6 0.9 6.5 7.1 1.2 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat CorA PF01544.18 CCF33242.1 - 4.2e-10 39.4 0.4 7.5e-10 38.6 0.4 1.4 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein Exonuc_VII_L PF02601.15 CCF33242.1 - 0.1 12.2 0.4 0.16 11.5 0.4 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit GMC_oxred_N PF00732.19 CCF33243.1 - 4.2e-64 216.8 0.3 6.3e-64 216.2 0.1 1.4 2 0 0 2 2 2 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCF33243.1 - 2e-33 115.9 0.1 3.9e-33 115.0 0.1 1.5 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 CCF33243.1 - 1.9e-06 27.2 0.1 0.011 14.8 0.0 2.3 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 CCF33243.1 - 0.0013 18.1 1.0 0.023 13.9 0.1 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCF33243.1 - 0.0016 18.1 1.5 0.062 12.9 0.1 2.4 2 1 0 2 2 2 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 CCF33243.1 - 0.0028 16.8 0.0 0.0046 16.1 0.0 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 CCF33243.1 - 0.0075 16.5 0.2 0.029 14.6 0.2 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 CCF33243.1 - 0.019 15.5 0.2 0.32 11.6 0.0 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CCF33243.1 - 0.063 12.5 0.7 0.14 11.4 0.1 1.7 2 0 0 2 2 2 0 Thi4 family FAD_oxidored PF12831.7 CCF33243.1 - 0.16 11.3 0.2 2.4 7.4 0.3 2.2 2 0 0 2 2 2 0 FAD dependent oxidoreductase HHH_5 PF14520.6 CCF33243.1 - 0.17 12.5 0.3 57 4.4 0.1 3.1 3 0 0 3 3 3 0 Helix-hairpin-helix domain Glyco_hydro_31 PF01055.26 CCF33244.1 - 1.4e-113 380.4 3.6 2.1e-113 379.9 3.6 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 CCF33244.1 - 9.7e-05 22.6 0.7 0.00056 20.2 0.1 2.6 2 1 0 2 2 2 1 Galactose mutarotase-like DUF4968 PF16338.5 CCF33244.1 - 0.0052 17.1 0.0 0.011 16.1 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4968) MFS_1 PF07690.16 CCF33245.1 - 3.7e-41 141.2 50.3 2.5e-40 138.5 45.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF33245.1 - 3.1e-05 23.0 13.4 3.1e-05 23.0 13.4 2.8 2 1 1 3 3 3 1 Sugar (and other) transporter Mad3_BUB1_I PF08311.12 CCF33246.1 - 9.8e-45 151.5 0.3 1.6e-44 150.8 0.3 1.3 1 0 0 1 1 1 1 Mad3/BUB1 homology region 1 Mad3_BUB1_I_2 PF17014.5 CCF33246.1 - 0.0035 17.5 0.0 0.0055 16.8 0.0 1.3 1 0 0 1 1 1 1 Putative Mad3/BUB1 like region 1 protein Tugs PF17840.1 CCF33246.1 - 0.046 13.9 0.2 0.35 11.1 0.0 2.2 2 0 0 2 2 2 0 Tethering Ubl4a to BAGS domain F-box-like PF12937.7 CCF33247.1 - 0.0001 22.1 0.3 0.00025 20.9 0.3 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCF33247.1 - 0.33 10.9 4.6 3.5 7.6 4.6 2.4 1 1 0 1 1 1 0 F-box domain Peptidase_S8 PF00082.22 CCF33248.1 - 7.1e-23 81.3 10.6 1.6e-22 80.2 10.6 1.5 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 CCF33248.1 - 5e-18 65.5 0.0 9.4e-18 64.7 0.0 1.5 1 0 0 1 1 1 1 Peptidase inhibitor I9 XFP_N PF09364.10 CCF33249.1 - 6.5e-131 436.5 0.0 3.1e-92 309.2 0.0 2.0 1 1 1 2 2 2 2 XFP N-terminal domain TPP_enzyme_C PF02775.21 CCF33249.1 - 0.00046 20.0 0.2 0.0062 16.3 0.1 2.3 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Catalase PF00199.19 CCF33250.1 - 5e-172 572.3 0.3 5e-172 572.3 0.3 1.5 2 0 0 2 2 2 1 Catalase Catalase-rel PF06628.12 CCF33250.1 - 8.2e-20 70.8 0.1 1.6e-19 69.9 0.1 1.5 1 0 0 1 1 1 1 Catalase-related immune-responsive Catalase_C PF18011.1 CCF33250.1 - 4.2e-07 29.7 0.3 1.1e-06 28.3 0.3 1.8 1 1 0 1 1 1 1 C-terminal domain found in long catalases DJ-1_PfpI PF01965.24 CCF33250.1 - 9e-05 22.3 0.0 0.00015 21.6 0.0 1.3 1 0 0 1 1 1 1 DJ-1/PfpI family DUF2140 PF09911.9 CCF33251.1 - 0.076 12.6 0.1 0.83 9.2 0.1 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2140) DUF1180 PF06679.12 CCF33251.1 - 0.71 10.3 8.2 0.076 13.4 1.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) Glyco_hydro_6 PF01341.17 CCF33252.1 - 2.6e-100 336.1 0.1 3.3e-100 335.8 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 6 Lipase_GDSL_2 PF13472.6 CCF33253.1 - 7.3e-08 33.0 0.2 1e-07 32.5 0.2 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 CCF33253.1 - 4.7e-05 23.4 0.0 5.4e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase S-AdoMet_synt_C PF02773.16 CCF33253.1 - 0.024 14.6 0.1 0.054 13.5 0.1 1.5 1 0 0 1 1 1 0 S-adenosylmethionine synthetase, C-terminal domain APH PF01636.23 CCF33254.1 - 5.5e-15 55.9 0.0 1.5e-14 54.5 0.0 1.6 2 0 0 2 2 2 1 Phosphotransferase enzyme family EcKinase PF02958.20 CCF33254.1 - 0.008 15.5 0.0 0.013 14.8 0.0 1.2 1 0 0 1 1 1 1 Ecdysteroid kinase DUF1679 PF07914.11 CCF33254.1 - 0.032 13.1 0.0 0.06 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) RIO1 PF01163.22 CCF33254.1 - 0.12 12.0 0.0 0.23 11.1 0.0 1.4 1 0 0 1 1 1 0 RIO1 family SBP_bac_3 PF00497.20 CCF33255.1 - 6.6e-28 97.7 0.7 3.6e-27 95.3 0.7 1.8 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Lig_chan-Glu_bd PF10613.9 CCF33255.1 - 0.025 14.7 0.1 0.22 11.7 0.0 2.5 2 1 0 2 2 2 0 Ligated ion channel L-glutamate- and glycine-binding site DUF1746 PF08508.10 CCF33256.1 - 0.034 14.5 0.9 0.043 14.2 0.9 1.0 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1746) PCI PF01399.27 CCF33257.1 - 1e-06 29.2 0.0 2e-06 28.3 0.0 1.5 1 0 0 1 1 1 1 PCI domain CSN7a_helixI PF18392.1 CCF33257.1 - 0.0076 16.1 0.0 0.015 15.2 0.0 1.5 1 0 0 1 1 1 1 COP9 signalosome complex subunit 7a helix I domain E1-E2_ATPase PF00122.20 CCF33259.1 - 3.7e-51 173.2 0.3 1.2e-50 171.5 0.3 1.9 1 0 0 1 1 1 1 E1-E2 ATPase HMA PF00403.26 CCF33259.1 - 7.5e-46 154.4 3.3 5.4e-12 46.0 0.0 4.6 4 0 0 4 4 4 4 Heavy-metal-associated domain Hydrolase PF00702.26 CCF33259.1 - 2.8e-37 129.0 1.3 6.9e-37 127.8 1.3 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 CCF33259.1 - 3.5e-05 23.7 1.3 0.00035 20.4 0.3 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase FAM70 PF14967.6 CCF33259.1 - 0.21 11.0 0.7 23 4.3 0.0 3.2 3 0 0 3 3 3 0 FAM70 protein DUF155 PF02582.14 CCF33260.1 - 7.1e-55 185.8 0.4 1.2e-54 185.1 0.1 1.5 2 0 0 2 2 2 1 Uncharacterised ACR, YagE family COG1723 Insulin_TMD PF17870.1 CCF33260.1 - 0.18 11.9 0.4 0.32 11.1 0.4 1.4 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment zinc_ribbon_15 PF17032.5 CCF33261.1 - 0.00023 21.8 0.6 0.00033 21.4 0.6 1.2 1 0 0 1 1 1 1 zinc-ribbon family RNase_P_p30 PF01876.16 CCF33262.1 - 2.2e-57 194.0 0.0 3.2e-57 193.5 0.0 1.2 1 0 0 1 1 1 1 RNase P subunit p30 RNase_T PF00929.24 CCF33263.1 - 2.6e-07 31.3 0.0 6.7e-07 30.0 0.0 1.7 1 1 0 1 1 1 1 Exonuclease Myb_DNA-binding PF00249.31 CCF33263.1 - 0.049 13.8 0.1 0.12 12.5 0.1 1.7 1 0 0 1 1 1 0 Myb-like DNA-binding domain An_peroxidase PF03098.15 CCF33263.1 - 0.2 10.2 0.0 0.34 9.4 0.0 1.3 1 0 0 1 1 1 0 Animal haem peroxidase DUF5082 PF16888.5 CCF33264.1 - 1.8e-06 28.2 0.5 2.8e-06 27.6 0.5 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF5082) Trimer_CC PF08954.11 CCF33264.1 - 0.00079 18.9 0.1 0.0013 18.2 0.1 1.5 1 1 0 1 1 1 1 Trimerisation motif Prefoldin PF02996.17 CCF33264.1 - 0.005 16.7 0.5 0.0071 16.3 0.3 1.3 1 1 0 1 1 1 1 Prefoldin subunit BLOC1_2 PF10046.9 CCF33264.1 - 0.035 14.4 0.5 0.061 13.6 0.5 1.5 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 SlyX PF04102.12 CCF33264.1 - 0.038 14.6 0.3 0.071 13.7 0.2 1.5 2 0 0 2 2 2 0 SlyX Lectin_N PF03954.14 CCF33264.1 - 0.049 13.4 0.0 0.055 13.2 0.0 1.1 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain DUF948 PF06103.11 CCF33264.1 - 0.059 13.6 0.8 0.11 12.7 0.6 1.5 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) SET PF00856.28 CCF33265.1 - 2.1e-09 38.0 0.0 2.2e-08 34.7 0.0 2.5 2 1 0 2 2 2 1 SET domain zf-MYND PF01753.18 CCF33265.1 - 1.3e-08 34.8 10.2 1.3e-08 34.8 10.2 2.0 2 0 0 2 2 2 1 MYND finger IL11 PF07400.11 CCF33265.1 - 0.025 14.3 0.1 0.51 10.0 0.1 2.3 2 0 0 2 2 2 0 Interleukin 11 SUI1 PF01253.22 CCF33266.1 - 6e-28 97.2 2.2 6e-28 97.2 2.2 1.5 2 0 0 2 2 2 1 Translation initiation factor SUI1 C_LFY_FLO PF17538.2 CCF33266.1 - 0.08 12.4 0.1 0.13 11.7 0.1 1.3 1 0 0 1 1 1 0 DNA Binding Domain (C-terminal) Leafy/Floricaula Polysacc_deac_1 PF01522.21 CCF33267.1 - 3.3e-25 88.4 0.1 1.2e-24 86.5 0.0 1.8 2 0 0 2 2 2 1 Polysaccharide deacetylase Chitin_bind_1 PF00187.19 CCF33267.1 - 1.5e-07 31.8 30.5 1.1e-06 29.0 16.0 2.6 2 0 0 2 2 2 2 Chitin recognition protein DUF2334 PF10096.9 CCF33267.1 - 0.00056 19.6 0.0 0.0012 18.6 0.0 1.4 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2334) zf-C2H2_4 PF13894.6 CCF33268.1 - 0.00095 19.8 16.4 0.042 14.7 1.8 3.8 3 0 0 3 3 3 2 C2H2-type zinc finger DUF4834 PF16118.5 CCF33268.1 - 0.25 12.3 3.8 0.68 10.9 3.8 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) zf-met PF12874.7 CCF33268.1 - 0.4 11.1 10.1 0.82 10.2 0.6 3.4 4 0 0 4 4 4 0 Zinc-finger of C2H2 type TFIIA PF03153.13 CCF33268.1 - 2.1 8.3 23.4 0.036 14.1 10.8 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit zf-C2H2 PF00096.26 CCF33268.1 - 2.1 9.0 14.2 0.3 11.6 1.1 3.2 3 0 0 3 3 3 0 Zinc finger, C2H2 type Peptidase_S64 PF08192.11 CCF33268.1 - 5.5 5.4 8.3 7.7 4.9 8.3 1.1 1 0 0 1 1 1 0 Peptidase family S64 Spt20 PF12090.8 CCF33268.1 - 7 6.2 22.6 0.021 14.5 12.8 1.8 2 0 0 2 2 2 0 Spt20 family Presenilin PF01080.17 CCF33268.1 - 9 4.9 5.6 13 4.4 5.6 1.2 1 0 0 1 1 1 0 Presenilin ABC2_membrane PF01061.24 CCF33269.1 - 2.2e-23 82.8 9.1 2.8e-23 82.4 9.1 1.2 1 0 0 1 1 1 1 ABC-2 type transporter ABC_trans_N PF14510.6 CCF33269.1 - 6.3e-19 68.4 0.0 1.6e-18 67.1 0.0 1.7 1 0 0 1 1 1 1 ABC-transporter N-terminal ABC_tran PF00005.27 CCF33269.1 - 5.4e-08 33.4 0.0 1.4e-05 25.7 0.0 2.3 2 0 0 2 2 2 2 ABC transporter AAA_16 PF13191.6 CCF33269.1 - 0.0088 16.4 0.6 0.017 15.5 0.1 1.8 2 0 0 2 2 2 1 AAA ATPase domain Dabb PF07876.12 CCF33270.1 - 1.1e-21 77.2 0.0 1.3e-21 77.0 0.0 1.0 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain p450 PF00067.22 CCF33272.1 - 2.1e-53 181.7 0.0 2.5e-53 181.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 RNase_H PF00075.24 CCF33272.1 - 0.0065 16.6 0.2 0.012 15.8 0.2 1.4 1 0 0 1 1 1 1 RNase H NmrA PF05368.13 CCF33274.1 - 1e-20 74.3 0.0 1.3e-20 74.0 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CCF33274.1 - 3.4e-17 62.9 0.0 6e-17 62.1 0.0 1.4 1 1 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 CCF33274.1 - 4e-05 23.9 0.2 0.00057 20.2 0.1 2.4 3 0 0 3 3 3 1 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 CCF33274.1 - 0.00028 20.9 0.0 0.00054 20.0 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase DapB_N PF01113.20 CCF33274.1 - 0.00046 20.3 0.7 0.0019 18.4 0.4 2.0 2 0 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus Epimerase PF01370.21 CCF33274.1 - 0.0073 15.8 0.2 0.069 12.6 0.0 2.4 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 CCF33274.1 - 0.049 14.1 0.1 0.46 10.9 0.1 2.3 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain Zn_clus PF00172.18 CCF33275.1 - 4.3e-07 29.9 6.8 8.9e-07 28.9 6.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain LpxD PF04613.14 CCF33275.1 - 0.088 12.6 0.1 0.65 9.8 0.0 2.4 2 0 0 2 2 2 0 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD Lectin_N PF03954.14 CCF33277.1 - 0.0041 16.9 0.9 0.0078 16.0 0.9 1.4 1 0 0 1 1 1 1 Hepatic lectin, N-terminal domain Tropomyosin_1 PF12718.7 CCF33277.1 - 0.015 15.5 3.7 0.015 15.5 3.7 1.7 2 0 0 2 2 2 0 Tropomyosin like CENP-F_leu_zip PF10473.9 CCF33277.1 - 0.095 12.7 4.0 0.2 11.7 4.0 1.5 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 NBP1 PF08537.10 CCF33277.1 - 0.32 10.4 5.1 0.076 12.4 1.4 1.8 2 0 0 2 2 2 0 Fungal Nap binding protein NBP1 Com_YlbF PF06133.11 CCF33277.1 - 0.39 11.3 2.5 0.44 11.2 0.9 1.8 2 0 0 2 2 2 0 Control of competence regulator ComK, YlbF/YmcA FUSC PF04632.12 CCF33277.1 - 0.9 8.0 3.3 6.9 5.1 3.3 1.9 1 1 0 1 1 1 0 Fusaric acid resistance protein family Fungal_trans PF04082.18 CCF33278.1 - 1e-10 41.1 0.0 2e-10 40.2 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF33278.1 - 1.4e-07 31.5 13.4 2.5e-07 30.7 13.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain HpcH_HpaI PF03328.14 CCF33279.1 - 2.1e-28 99.0 0.0 2.7e-28 98.6 0.0 1.1 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family PEP-utilizers_C PF02896.18 CCF33279.1 - 0.08 12.0 0.2 0.56 9.3 0.1 2.4 1 1 0 2 2 2 0 PEP-utilising enzyme, TIM barrel domain DUF3792 PF12670.7 CCF33280.1 - 0.0033 17.6 0.2 0.0041 17.3 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3792) OppC_N PF12911.7 CCF33280.1 - 0.014 15.3 0.0 0.22 11.5 0.0 2.2 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C DUF3149 PF11346.8 CCF33280.1 - 0.03 13.9 0.2 0.03 13.9 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3149) Acyl_transf_3 PF01757.22 CCF33280.1 - 0.05 12.7 0.0 0.053 12.6 0.0 1.0 1 0 0 1 1 1 0 Acyltransferase family DUF2663 PF10864.8 CCF33280.1 - 0.071 13.5 0.0 0.083 13.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2663) Asp-Al_Ex PF06826.12 CCF33280.1 - 0.11 12.3 0.0 0.13 12.0 0.0 1.1 1 0 0 1 1 1 0 Predicted Permease Membrane Region DUF2206 PF09971.9 CCF33280.1 - 0.11 11.2 0.0 0.14 10.9 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2206) ArAE_2_N PF10337.9 CCF33280.1 - 0.2 10.7 1.1 0.23 10.5 1.1 1.1 1 0 0 1 1 1 0 Putative ER transporter, 6TM, N-terminal Cys_Met_Meta_PP PF01053.20 CCF33281.1 - 4.8e-139 463.2 0.0 5.4e-139 463.0 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 CCF33281.1 - 1.8e-07 30.7 0.2 2.8e-07 30.0 0.2 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 CCF33281.1 - 5.2e-07 28.9 0.6 9.4e-07 28.1 0.6 1.3 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 CCF33281.1 - 4.1e-06 26.3 0.9 6.9e-06 25.6 0.9 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.21 CCF33281.1 - 0.031 13.5 0.3 0.061 12.6 0.3 1.6 1 1 0 1 1 1 0 Beta-eliminating lyase Peptidase_S58 PF03576.14 CCF33282.1 - 0.12 11.8 0.4 0.17 11.4 0.4 1.1 1 0 0 1 1 1 0 Peptidase family S58 Pkinase PF00069.25 CCF33283.1 - 3.1e-68 230.0 0.0 4.2e-68 229.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF33283.1 - 5.6e-33 114.3 0.3 1.8e-32 112.6 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF33283.1 - 3.3e-05 23.3 0.0 4.9e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 CCF33283.1 - 0.00054 19.4 0.0 0.0011 18.4 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 CCF33283.1 - 0.0091 15.5 0.1 0.088 12.3 0.1 2.5 3 0 0 3 3 3 1 PhoP regulatory network protein YrbL Condensation PF00668.20 CCF33285.1 - 4.3e-42 144.4 0.1 5.3e-42 144.0 0.1 1.0 1 0 0 1 1 1 1 Condensation domain MFS_1 PF07690.16 CCF33286.1 - 1.4e-16 60.4 14.5 1.7e-16 60.1 14.5 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily FAD_binding_4 PF01565.23 CCF33287.1 - 3e-20 72.4 1.4 7e-20 71.2 1.4 1.7 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 CCF33287.1 - 0.0056 16.7 0.1 0.01 15.9 0.1 1.4 1 0 0 1 1 1 1 Berberine and berberine like RRM_1 PF00076.22 CCF33289.1 - 1e-83 275.2 5.7 4.7e-21 74.4 0.1 5.3 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CCF33289.1 - 5.3e-09 35.7 0.0 0.014 15.0 0.0 5.0 3 2 2 5 5 5 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CCF33289.1 - 1.8e-07 30.9 0.0 7.4e-05 22.5 0.0 3.5 4 0 0 4 4 4 1 Occluded RNA-recognition motif RRM_7 PF16367.5 CCF33289.1 - 3.1e-05 24.0 0.2 0.71 10.0 0.0 5.2 5 0 0 5 5 5 1 RNA recognition motif Nup35_RRM_2 PF14605.6 CCF33289.1 - 0.00031 20.7 1.3 12 6.0 0.1 4.9 4 1 0 4 4 4 0 Nup53/35/40-type RNA recognition motif CbiG_mid PF11761.8 CCF33289.1 - 0.00081 19.5 0.0 12 6.1 0.0 3.6 3 0 0 3 3 3 0 Cobalamin biosynthesis central region OB_RNB PF08206.11 CCF33289.1 - 0.0071 16.0 1.4 7.8 6.3 0.0 3.7 3 0 0 3 3 3 1 Ribonuclease B OB domain YflT PF11181.8 CCF33289.1 - 0.0072 16.8 4.3 0.21 12.1 0.3 3.4 3 0 0 3 3 3 1 Heat induced stress protein YflT Limkain-b1 PF11608.8 CCF33289.1 - 0.035 14.2 1.2 27 4.9 0.0 3.5 3 0 0 3 3 3 0 Limkain b1 Nefa_Nip30_N PF10187.9 CCF33289.1 - 0.098 13.0 0.1 0.098 13.0 0.1 3.4 4 0 0 4 4 3 0 N-terminal domain of NEFA-interacting nuclear protein NIP30 NPR3 PF03666.13 CCF33289.1 - 0.25 10.1 6.2 0.39 9.5 6.2 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SAPS PF04499.15 CCF33289.1 - 0.71 8.6 4.7 1.1 8.0 4.7 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein PhetRS_B1 PF18262.1 CCF33289.1 - 0.94 9.7 2.8 88 3.4 0.8 3.4 3 1 0 3 3 3 0 Phe-tRNA synthetase beta subunit B1 domain CDC45 PF02724.14 CCF33289.1 - 1.4 7.2 13.6 2 6.6 13.6 1.2 1 0 0 1 1 1 0 CDC45-like protein RNA_polI_A34 PF08208.11 CCF33289.1 - 1.6 8.8 18.3 0.21 11.6 12.1 2.2 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 DNA_pol_phi PF04931.13 CCF33289.1 - 2.7 6.0 14.5 3.9 5.5 14.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi Presenilin PF01080.17 CCF33289.1 - 6.7 5.4 6.6 9.5 4.9 6.6 1.2 1 0 0 1 1 1 0 Presenilin HECT PF00632.25 CCF33290.1 - 4.5e-84 282.5 0.0 7.9e-84 281.7 0.0 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) IQ PF00612.27 CCF33290.1 - 0.0028 17.3 2.8 0.0069 16.1 2.8 1.7 1 0 0 1 1 1 1 IQ calmodulin-binding motif DUF3807 PF12720.7 CCF33290.1 - 0.46 10.7 3.2 0.56 10.5 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) Glyco_hydro_125 PF06824.11 CCF33291.1 - 1.2e-176 587.6 0.0 1.4e-176 587.4 0.0 1.0 1 0 0 1 1 1 1 Metal-independent alpha-mannosidase (GH125) Glyco_hydro_92 PF07971.12 CCF33292.1 - 1.1e-146 489.5 0.0 1.4e-146 489.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 CCF33292.1 - 5.3e-67 226.2 0.2 8.4e-67 225.5 0.2 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain DAO PF01266.24 CCF33293.1 - 2.9e-09 37.0 1.5 3.5e-05 23.5 0.3 2.8 2 1 1 3 3 3 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CCF33293.1 - 9.4e-08 32.2 0.0 3.6e-07 30.3 0.0 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CCF33293.1 - 1.3e-06 27.8 0.0 8.9e-06 25.1 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CCF33293.1 - 1e-05 24.9 0.9 0.00012 21.3 1.1 2.1 1 1 0 2 2 2 1 FAD binding domain HI0933_like PF03486.14 CCF33293.1 - 3e-05 22.9 0.6 4.3e-05 22.4 0.6 1.2 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox PF00070.27 CCF33293.1 - 9.4e-05 22.9 0.5 0.32 11.6 0.5 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CCF33293.1 - 9.4e-05 21.8 0.2 0.00023 20.5 0.1 1.6 2 0 0 2 2 2 1 Thi4 family FAD_binding_3 PF01494.19 CCF33293.1 - 0.00029 20.2 0.1 0.00059 19.2 0.2 1.5 2 0 0 2 2 2 1 FAD binding domain NAD_binding_9 PF13454.6 CCF33293.1 - 0.00039 20.4 0.1 0.0015 18.6 0.2 1.8 2 0 0 2 2 2 1 FAD-NAD(P)-binding Trp_halogenase PF04820.14 CCF33293.1 - 0.00041 19.3 0.1 0.02 13.8 0.2 2.1 2 0 0 2 2 2 1 Tryptophan halogenase FAD_oxidored PF12831.7 CCF33293.1 - 0.00044 19.7 0.0 0.00051 19.5 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 CCF33293.1 - 0.002 17.5 0.2 0.0026 17.1 0.2 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 CCF33293.1 - 0.0035 16.5 0.2 0.0062 15.6 0.2 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein AlaDh_PNT_C PF01262.21 CCF33293.1 - 0.017 14.4 0.0 0.028 13.7 0.0 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 CCF33293.1 - 0.024 13.7 0.1 0.032 13.3 0.1 1.1 1 0 0 1 1 1 0 Glucose inhibited division protein A K_oxygenase PF13434.6 CCF33293.1 - 0.1 11.7 0.0 0.14 11.3 0.0 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Cupin_1 PF00190.22 CCF33294.1 - 3.5e-41 140.3 0.0 7.9e-21 74.2 0.0 2.2 2 0 0 2 2 2 2 Cupin Cupin_2 PF07883.11 CCF33294.1 - 9.8e-23 79.7 0.5 2.1e-12 46.6 0.0 2.4 2 0 0 2 2 2 2 Cupin domain AraC_binding PF02311.19 CCF33294.1 - 2.2e-05 24.4 0.1 0.019 14.9 0.0 2.5 2 0 0 2 2 2 2 AraC-like ligand binding domain Cupin_3 PF05899.12 CCF33294.1 - 8.2e-05 22.2 0.0 0.27 10.9 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF861) CENP-C_C PF11699.8 CCF33294.1 - 0.022 15.0 0.0 0.19 11.9 0.0 2.4 3 0 0 3 3 3 0 Mif2/CENP-C like 3-HAO PF06052.12 CCF33294.1 - 0.031 13.9 0.0 0.5 10.0 0.0 2.2 2 0 0 2 2 2 0 3-hydroxyanthranilic acid dioxygenase Cupin_6 PF12852.7 CCF33294.1 - 0.047 13.4 0.0 9.7 5.9 0.0 2.2 2 0 0 2 2 2 0 Cupin Binary_toxB PF03495.14 CCF33295.1 - 0.12 12.6 0.5 0.27 11.4 0.5 1.6 1 0 0 1 1 1 0 Clostridial binary toxin B/anthrax toxin PA Ca-binding domain Cuticle_3 PF11018.8 CCF33295.1 - 3.2 7.9 6.4 8.4 6.6 0.2 2.7 3 0 0 3 3 3 0 Pupal cuticle protein C1 Zn_clus PF00172.18 CCF33297.1 - 0.0069 16.5 10.6 0.012 15.8 10.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Mito_carr PF00153.27 CCF33298.1 - 2.4e-72 239.0 3.3 3.2e-24 84.7 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 CCF33298.1 - 0.0037 16.5 3.0 2.8 7.0 0.1 3.7 2 2 2 4 4 4 2 Gammaproteobacterial serine protease PX PF00787.24 CCF33299.1 - 5.5e-25 87.6 0.0 6.3e-25 87.4 0.0 1.0 1 0 0 1 1 1 1 PX domain DUF3987 PF13148.6 CCF33302.1 - 0.99 8.3 6.0 1.1 8.2 6.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) Ribosomal_L2_C PF03947.18 CCF33303.1 - 9.1e-52 174.5 2.8 2.2e-51 173.3 2.5 1.9 2 0 0 2 2 2 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 CCF33303.1 - 3.8e-24 84.4 0.9 6.1e-24 83.8 0.2 1.7 2 0 0 2 2 2 1 Ribosomal Proteins L2, RNA binding domain zf-CCHC PF00098.23 CCF33305.1 - 2e-45 150.9 60.1 5.3e-08 32.6 2.5 7.2 7 0 0 7 7 7 7 Zinc knuckle zf-CCHC_4 PF14392.6 CCF33305.1 - 4.2e-10 39.2 38.8 0.16 11.7 1.1 7.1 7 0 0 7 7 7 6 Zinc knuckle zf-CCHC_5 PF14787.6 CCF33305.1 - 9.8e-07 28.4 41.9 0.007 16.1 1.0 7.1 4 2 3 7 7 7 5 GAG-polyprotein viral zinc-finger zf-CCHC_3 PF13917.6 CCF33305.1 - 4.5e-05 23.3 41.8 0.094 12.7 0.1 6.9 4 2 1 5 5 5 3 Zinc knuckle zf-CCHC_2 PF13696.6 CCF33305.1 - 0.046 13.5 1.4 0.046 13.5 1.4 7.1 7 0 0 7 7 7 0 Zinc knuckle zf-CCHC_6 PF15288.6 CCF33305.1 - 0.12 12.2 0.2 0.12 12.2 0.2 7.0 6 1 1 7 7 7 0 Zinc knuckle Peptidase_C2 PF00648.21 CCF33306.1 - 6.3e-63 212.6 2.5 2.3e-61 207.4 2.5 2.4 1 1 0 1 1 1 1 Calpain family cysteine protease FTA4 PF13093.6 CCF33307.1 - 3.6e-53 180.5 0.0 4.7e-53 180.1 0.0 1.0 1 0 0 1 1 1 1 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 SPR1 PF15356.6 CCF33307.1 - 1.3 9.6 5.6 1 9.9 0.2 2.3 2 0 0 2 2 2 0 Psoriasis susceptibility locus 2 TRAPP PF04051.16 CCF33308.1 - 1.4e-38 131.9 0.0 1.6e-38 131.7 0.0 1.0 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Apc13p PF05839.11 CCF33309.1 - 4e-31 107.0 0.2 7e-31 106.3 0.2 1.3 1 0 0 1 1 1 1 Apc13p protein Ntox21 PF15526.6 CCF33309.1 - 0.1 12.9 0.7 0.17 12.2 0.7 1.4 1 0 0 1 1 1 0 Novel toxin 21 SBP_bac_5 PF00496.22 CCF33311.1 - 0.00044 19.3 0.6 0.00075 18.6 0.6 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 5 Middle Hexapep PF00132.24 CCF33313.1 - 7.8e-08 31.8 11.4 8.4e-05 22.1 2.4 3.7 4 0 0 4 4 4 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 CCF33313.1 - 7.1e-06 25.7 12.7 0.0021 17.8 1.3 3.1 3 1 0 3 3 3 2 Hexapeptide repeat of succinyl-transferase Complex1_51K PF01512.17 CCF33314.1 - 1.6e-47 161.2 0.0 2.5e-47 160.5 0.0 1.3 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase 51 Kd subunit NADH_4Fe-4S PF10589.9 CCF33314.1 - 4.6e-29 100.3 0.9 8.4e-29 99.5 0.1 1.8 2 0 0 2 2 2 1 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region SLBB PF10531.9 CCF33314.1 - 9.5e-09 35.0 0.0 3e-08 33.4 0.0 1.9 1 0 0 1 1 1 1 SLBB domain PEX11 PF05648.14 CCF33315.1 - 6.8e-15 55.1 0.0 1.6e-09 37.6 0.0 3.0 2 2 0 2 2 2 2 Peroxisomal biogenesis factor 11 (PEX11) AAA_2 PF07724.14 CCF33316.1 - 5.6e-46 156.8 0.0 1.9e-44 151.8 0.0 3.0 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 CCF33316.1 - 4.1e-33 113.4 14.4 3.3e-32 110.5 1.8 3.8 4 0 0 4 4 3 2 AAA lid domain AAA PF00004.29 CCF33316.1 - 1e-26 94.0 0.0 5e-14 52.8 0.0 2.9 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 CCF33316.1 - 1.5e-24 85.9 1.8 5.5e-24 84.0 0.5 2.8 2 0 0 2 2 2 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.14 CCF33316.1 - 5.4e-16 58.9 0.0 5e-10 39.5 0.0 3.2 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 CCF33316.1 - 1.5e-12 47.9 0.0 6.2e-05 23.3 0.0 4.3 2 1 1 3 3 2 2 AAA domain AAA_16 PF13191.6 CCF33316.1 - 6.6e-11 42.9 15.5 1.1e-06 29.1 0.1 5.6 4 4 1 6 6 6 2 AAA ATPase domain Sigma54_activat PF00158.26 CCF33316.1 - 4.3e-09 36.3 0.0 5.5e-06 26.2 0.0 2.7 2 1 0 2 2 2 2 Sigma-54 interaction domain Clp_N PF02861.20 CCF33316.1 - 1.7e-08 34.4 2.7 0.00013 22.0 0.3 3.9 3 0 0 3 3 3 1 Clp amino terminal domain, pathogenicity island component Mg_chelatase PF01078.21 CCF33316.1 - 2.1e-06 27.3 0.0 0.23 10.8 0.0 3.7 2 1 0 3 3 3 2 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 CCF33316.1 - 2.7e-06 27.5 0.0 0.15 12.1 0.0 3.0 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.6 CCF33316.1 - 3.5e-06 27.2 0.4 0.25 11.5 0.0 3.8 2 1 1 3 3 2 2 AAA domain IstB_IS21 PF01695.17 CCF33316.1 - 3.6e-06 26.8 0.0 0.07 12.9 0.0 2.7 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_7 PF12775.7 CCF33316.1 - 5.9e-06 25.9 0.0 0.019 14.5 0.0 2.6 2 0 0 2 2 2 2 P-loop containing dynein motor region ATPase_2 PF01637.18 CCF33316.1 - 3.1e-05 24.0 6.8 0.03 14.3 0.2 4.8 3 2 1 5 5 5 1 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 CCF33316.1 - 4.1e-05 23.9 0.0 0.57 10.6 0.0 3.0 3 0 0 3 3 2 2 RNA helicase AAA_28 PF13521.6 CCF33316.1 - 4.6e-05 23.7 0.0 0.45 10.7 0.0 3.3 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 CCF33316.1 - 5e-05 23.8 4.4 0.14 12.7 0.0 4.0 3 1 1 4 4 3 2 AAA domain RsgA_GTPase PF03193.16 CCF33316.1 - 0.00018 21.5 0.0 0.21 11.5 0.0 2.9 2 0 0 2 2 2 1 RsgA GTPase RuvB_N PF05496.12 CCF33316.1 - 0.00019 21.2 1.3 2.6 7.8 0.7 4.3 3 1 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain AAA_30 PF13604.6 CCF33316.1 - 0.00019 21.2 0.0 1.1 8.9 0.0 3.0 2 0 0 2 2 2 2 AAA domain AAA_3 PF07726.11 CCF33316.1 - 0.00019 21.3 0.1 1 9.2 0.0 3.7 4 0 0 4 4 3 1 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 CCF33316.1 - 0.00023 21.2 0.0 0.34 10.9 0.0 2.6 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 CCF33316.1 - 0.00055 19.9 0.0 0.21 11.5 0.0 3.5 3 0 0 3 3 3 1 NACHT domain ABC_tran PF00005.27 CCF33316.1 - 0.00096 19.7 0.1 1.3 9.6 0.0 3.2 3 0 0 3 3 2 1 ABC transporter T2SSE PF00437.20 CCF33316.1 - 0.0012 18.0 0.6 0.016 14.3 0.0 2.9 3 0 0 3 3 3 1 Type II/IV secretion system protein AAA_24 PF13479.6 CCF33316.1 - 0.0017 18.1 2.7 0.59 9.8 0.0 3.4 4 1 0 4 4 3 1 AAA domain AAA_29 PF13555.6 CCF33316.1 - 0.004 16.9 0.0 4.3 7.2 0.0 2.7 2 0 0 2 2 2 0 P-loop containing region of AAA domain Rad17 PF03215.15 CCF33316.1 - 0.0048 16.8 0.1 4.6 7.1 0.0 3.1 3 0 0 3 3 2 0 Rad17 P-loop domain ResIII PF04851.15 CCF33316.1 - 0.0052 16.8 0.0 0.8 9.7 0.0 3.5 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 CCF33316.1 - 0.0061 16.9 4.8 0.25 11.7 0.0 4.0 5 1 0 5 5 3 1 AAA domain Roc PF08477.13 CCF33316.1 - 0.0063 16.7 0.0 2.1 8.6 0.0 2.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase NTPase_1 PF03266.15 CCF33316.1 - 0.0081 16.1 0.0 0.22 11.4 0.0 3.0 3 0 0 3 3 2 1 NTPase Torsin PF06309.11 CCF33316.1 - 0.0092 16.1 0.0 0.045 13.8 0.0 2.0 2 0 0 2 2 2 1 Torsin Zeta_toxin PF06414.12 CCF33316.1 - 0.012 15.0 0.0 1.2 8.3 0.0 2.7 2 0 0 2 2 2 0 Zeta toxin AAA_25 PF13481.6 CCF33316.1 - 0.014 15.0 1.9 1.7 8.1 0.0 3.5 3 0 0 3 3 3 0 AAA domain SRP54 PF00448.22 CCF33316.1 - 0.023 14.3 0.0 4.6 6.8 0.0 2.8 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain DUF815 PF05673.13 CCF33316.1 - 0.026 13.7 0.0 2.4 7.2 0.0 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF815) AAA_23 PF13476.6 CCF33316.1 - 0.032 14.7 13.6 0.38 11.2 0.0 4.2 4 1 0 4 4 2 0 AAA domain KTI12 PF08433.10 CCF33316.1 - 0.038 13.4 1.2 11 5.4 0.0 3.4 4 0 0 4 4 3 0 Chromatin associated protein KTI12 Cytidylate_kin PF02224.18 CCF33316.1 - 0.064 13.0 6.4 20 4.8 0.9 4.5 5 0 0 5 5 5 0 Cytidylate kinase ATP_bind_1 PF03029.17 CCF33316.1 - 0.076 12.8 0.0 7.1 6.3 0.0 2.6 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_15 PF13175.6 CCF33316.1 - 0.084 12.6 1.2 23 4.5 0.3 3.4 4 0 0 4 4 3 0 AAA ATPase domain PduV-EutP PF10662.9 CCF33316.1 - 0.098 12.4 0.0 7.6 6.3 0.0 2.8 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation CorA PF01544.18 CCF33316.1 - 0.94 8.7 4.5 3.1 7.0 4.5 1.9 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Cob_adeno_trans PF01923.18 CCF33316.1 - 1.8 8.7 10.1 0.14 12.2 3.2 2.6 3 0 0 3 3 2 0 Cobalamin adenosyltransferase Cep57_CLD_2 PF14197.6 CCF33316.1 - 2.4 8.3 13.3 0.2 11.8 7.7 2.2 2 0 0 2 2 1 0 Centrosome localisation domain of PPC89 Mhr1 PF12829.7 CCF33317.1 - 2.8e-36 123.4 0.0 4.5e-36 122.8 0.0 1.3 1 0 0 1 1 1 1 Transcriptional regulation of mitochondrial recombination Sulfotransfer_3 PF13469.6 CCF33318.1 - 7e-06 26.6 0.0 1.4e-05 25.6 0.0 1.4 1 0 0 1 1 1 1 Sulfotransferase family TFIID-18kDa PF02269.16 CCF33320.1 - 8.1e-28 96.3 1.9 4.4e-27 93.9 0.2 2.6 3 0 0 3 3 3 1 Transcription initiation factor IID, 18kD subunit TAFII28 PF04719.14 CCF33320.1 - 0.063 13.4 0.0 0.17 12.0 0.0 1.7 1 1 0 1 1 1 0 hTAFII28-like protein conserved region Myc_N PF01056.18 CCF33320.1 - 0.086 12.7 0.4 0.14 12.0 0.4 1.3 1 0 0 1 1 1 0 Myc amino-terminal region Ist1 PF03398.14 CCF33321.1 - 3.2e-63 212.5 3.3 4.8e-63 212.0 3.3 1.3 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway Glyco_hydro81C PF17652.1 CCF33322.1 - 7.1e-132 439.9 2.6 9.3e-132 439.5 2.6 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 C-terminal domain Glyco_hydro_81 PF03639.13 CCF33322.1 - 2.7e-101 339.0 0.5 3.5e-101 338.6 0.5 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 N-terminal domain Glu_cyclase_2 PF05096.12 CCF33322.1 - 0.061 12.7 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Glutamine cyclotransferase AMP-binding PF00501.28 CCF33323.1 - 6.7e-67 225.9 0.2 4.4e-35 121.1 0.0 4.1 2 2 0 2 2 2 2 AMP-binding enzyme CxC6 PF18721.1 CCF33324.1 - 0.0067 16.7 13.6 0.19 12.0 8.0 3.1 2 0 0 2 2 2 2 CxC6 like cysteine cluster associated with KDZ transposases DUF5308 PF17233.2 CCF33325.1 - 9.6e-55 185.3 4.8 1.1e-54 185.1 4.8 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5308) Transketolase_N PF00456.21 CCF33326.1 - 4.5e-146 486.1 0.0 6.8e-146 485.5 0.0 1.3 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 CCF33326.1 - 1.6e-44 151.7 0.0 2.6e-44 151.0 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 CCF33326.1 - 4.9e-12 45.8 0.0 9.7e-12 44.9 0.0 1.5 1 0 0 1 1 1 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.6 CCF33326.1 - 0.0002 20.6 0.0 0.00036 19.8 0.0 1.4 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase tRNA-synt_1 PF00133.22 CCF33328.1 - 6.3e-165 549.8 0.0 7.9e-165 549.5 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 CCF33328.1 - 5.1e-09 36.3 0.0 8.8e-09 35.5 0.0 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 CCF33328.1 - 3.6e-07 29.3 0.0 0.014 14.1 0.1 2.5 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 CCF33328.1 - 0.013 14.8 0.0 0.022 14.1 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain tRNA-synt_1 PF00133.22 CCF33329.1 - 1.4e-50 172.2 0.0 1.5e-50 172.1 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 CCF33329.1 - 2.3e-06 26.6 0.0 2.8e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (M) Mo25 PF08569.11 CCF33330.1 - 5e-130 433.6 0.0 5.7e-130 433.5 0.0 1.0 1 0 0 1 1 1 1 Mo25-like DNA_topoisoIV PF00521.20 CCF33330.1 - 0.0097 14.8 0.0 0.019 13.9 0.0 1.4 1 0 0 1 1 1 1 DNA gyrase/topoisomerase IV, subunit A adh_short PF00106.25 CCF33331.1 - 2.2e-34 118.6 0.0 2.8e-34 118.3 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF33331.1 - 1.6e-25 90.1 0.0 1.9e-25 89.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF33331.1 - 4.2e-05 23.5 0.1 9.5e-05 22.4 0.1 1.6 1 1 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 CCF33331.1 - 0.00022 21.1 0.4 0.00053 19.9 0.4 1.7 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 CCF33331.1 - 0.0043 17.3 0.1 0.0091 16.3 0.1 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain F420_oxidored PF03807.17 CCF33331.1 - 0.0044 17.6 0.2 0.0098 16.5 0.2 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Epimerase PF01370.21 CCF33331.1 - 0.0044 16.5 0.3 0.008 15.7 0.3 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 2-Hacid_dh_C PF02826.19 CCF33331.1 - 0.011 15.1 0.0 0.029 13.7 0.1 1.6 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TrkA_N PF02254.18 CCF33331.1 - 0.013 15.7 0.5 0.035 14.4 0.3 1.7 2 0 0 2 2 2 0 TrkA-N domain Pyr_redox PF00070.27 CCF33331.1 - 0.014 16.0 0.8 0.032 14.8 0.8 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCF33331.1 - 0.12 12.6 0.3 0.26 11.5 0.3 1.5 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CCF33331.1 - 0.13 11.5 0.7 0.28 10.4 0.3 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 CCF33331.1 - 0.31 10.3 2.5 0.22 10.8 0.7 1.7 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain SWIB PF02201.18 CCF33332.1 - 8e-22 76.9 0.0 2.2e-21 75.5 0.0 1.7 2 0 0 2 2 2 1 SWIB/MDM2 domain DNA_pol_E_B PF04042.16 CCF33332.1 - 0.081 12.3 0.1 0.13 11.6 0.1 1.3 1 0 0 1 1 1 0 DNA polymerase alpha/epsilon subunit B Csm1 PF12539.8 CCF33333.1 - 1e-31 109.4 0.0 2.3e-31 108.3 0.0 1.6 1 0 0 1 1 1 1 Chromosome segregation protein Csm1/Pcs1 HERV-K_REC PF15695.5 CCF33333.1 - 0.0029 17.6 0.3 0.0029 17.6 0.3 2.3 2 0 0 2 2 2 1 Rec (regulator of expression encoded by corf) of HERV-K-113 BST2 PF16716.5 CCF33333.1 - 0.0084 16.7 5.9 0.023 15.3 5.9 1.8 1 0 0 1 1 1 1 Bone marrow stromal antigen 2 GAS PF13851.6 CCF33333.1 - 0.049 13.0 8.6 0.044 13.1 3.8 2.3 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding V_ATPase_I PF01496.19 CCF33333.1 - 0.053 11.4 0.6 0.1 10.5 0.6 1.4 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Spc24 PF08286.11 CCF33333.1 - 0.055 13.7 1.6 0.19 12.0 0.1 2.5 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 Prefoldin PF02996.17 CCF33333.1 - 0.068 13.1 3.8 0.28 11.1 3.7 2.1 1 1 0 1 1 1 0 Prefoldin subunit Sulfatase_C PF14707.6 CCF33333.1 - 0.11 13.3 0.3 0.25 12.1 0.3 1.6 1 0 0 1 1 1 0 C-terminal region of aryl-sulfatase HIP1_clath_bdg PF16515.5 CCF33333.1 - 0.15 12.7 10.6 1.1 9.9 9.6 2.7 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 EMP24_GP25L PF01105.24 CCF33333.1 - 0.15 12.0 0.3 0.39 10.6 0.3 1.7 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD DUF148 PF02520.17 CCF33333.1 - 0.21 11.7 8.8 0.34 11.0 4.4 2.5 2 0 0 2 2 2 0 Domain of unknown function DUF148 CENP-K PF11802.8 CCF33333.1 - 0.29 10.7 4.8 0.54 9.8 4.8 1.4 1 0 0 1 1 1 0 Centromere-associated protein K FliJ PF02050.16 CCF33333.1 - 0.29 11.4 10.5 0.38 11.0 9.1 1.9 1 1 1 2 2 2 0 Flagellar FliJ protein Atg14 PF10186.9 CCF33333.1 - 0.33 10.0 5.7 0.71 8.9 5.7 1.5 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Macoilin PF09726.9 CCF33333.1 - 5.3 5.5 28.4 15 4.0 28.4 1.5 1 1 0 1 1 1 0 Macoilin family XhlA PF10779.9 CCF33333.1 - 7.2 6.9 6.1 18 5.6 0.3 3.5 2 1 0 2 2 2 0 Haemolysin XhlA UPF0242 PF06785.11 CCF33333.1 - 8.3 6.5 10.0 29 4.7 10.0 2.0 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus PigN PF04987.14 CCF33334.1 - 8.7e-165 549.0 29.3 8.7e-165 549.0 29.3 1.8 2 0 0 2 2 2 1 Phosphatidylinositolglycan class N (PIG-N) Phosphodiest PF01663.22 CCF33334.1 - 9.7e-10 38.6 3.6 1.9e-08 34.3 3.5 2.2 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 CCF33334.1 - 2.5e-09 37.0 0.2 4e-09 36.3 0.2 1.3 1 0 0 1 1 1 1 Sulfatase Metalloenzyme PF01676.18 CCF33334.1 - 4.7e-05 22.9 0.0 7.5e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 Metalloenzyme superfamily CBS PF00571.28 CCF33335.1 - 3.7e-35 120.2 3.4 5.1e-09 36.5 0.0 5.2 4 0 0 4 4 4 4 CBS domain PB1 PF00564.24 CCF33335.1 - 6.8e-08 32.3 0.1 2.3e-07 30.7 0.0 2.0 2 0 0 2 2 2 1 PB1 domain Ribosomal_S2 PF00318.20 CCF33336.1 - 1.4e-64 217.3 0.1 1.9e-63 213.6 0.1 2.1 1 1 0 1 1 1 1 Ribosomal protein S2 LDcluster4 PF18306.1 CCF33336.1 - 0.037 13.6 0.2 0.076 12.6 0.2 1.5 1 0 0 1 1 1 0 SLOG cluster4 family DUF1330 PF07045.11 CCF33336.1 - 0.14 12.5 0.2 0.34 11.3 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1330) AA_permease PF00324.21 CCF33338.1 - 1.1e-128 429.9 33.8 1.3e-128 429.6 33.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CCF33338.1 - 4.6e-41 141.0 37.4 6e-41 140.7 37.4 1.1 1 0 0 1 1 1 1 Amino acid permease Amidase PF01425.21 CCF33339.1 - 2.7e-72 244.2 0.0 1.5e-71 241.7 0.0 1.8 1 1 0 1 1 1 1 Amidase Adhesin_P1 PF03257.13 CCF33339.1 - 0.06 13.9 0.1 0.93 10.1 0.0 2.4 2 0 0 2 2 2 0 Mycoplasma adhesin P1 CEP170_C PF15308.6 CCF33340.1 - 8.7 4.8 7.0 11 4.4 7.0 1.1 1 0 0 1 1 1 0 CEP170 C-terminus HSP70 PF00012.20 CCF33341.1 - 6.8e-11 41.1 0.2 3.8e-10 38.6 0.0 1.8 2 0 0 2 2 2 1 Hsp70 protein FtsA PF14450.6 CCF33341.1 - 0.0032 17.9 0.1 0.034 14.6 0.0 2.3 2 0 0 2 2 2 1 Cell division protein FtsA Aminotran_5 PF00266.19 CCF33343.1 - 1.2e-08 34.4 0.0 8.7e-08 31.5 0.0 1.9 2 0 0 2 2 2 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 CCF33343.1 - 0.0051 16.2 0.0 0.0077 15.6 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.21 CCF33343.1 - 0.099 11.8 0.0 0.65 9.1 0.0 2.0 2 0 0 2 2 2 0 Aminotransferase class I and II PLDc_N PF13396.6 CCF33344.1 - 4.8e-12 45.6 3.9 8e-12 44.9 3.9 1.4 1 0 0 1 1 1 1 Phospholipase_D-nuclease N-terminal DUF2207 PF09972.9 CCF33344.1 - 0.25 10.0 1.5 0.24 10.1 1.5 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Peptidase_S8 PF00082.22 CCF33346.1 - 2.1e-14 53.5 0.2 3.3e-14 52.9 0.2 1.2 1 0 0 1 1 1 1 Subtilase family LIM PF00412.22 CCF33347.1 - 2e-15 56.8 17.8 7e-10 39.0 1.7 2.3 2 0 0 2 2 2 2 LIM domain Zn-ribbon_8 PF09723.10 CCF33347.1 - 0.17 12.0 17.8 0.35 11.0 1.2 4.3 3 1 1 4 4 4 0 Zinc ribbon domain zf-ribbon_3 PF13248.6 CCF33347.1 - 0.27 10.7 0.0 0.27 10.7 0.0 5.2 6 1 0 6 6 6 0 zinc-ribbon domain GalP_UDP_transf PF01087.22 CCF33349.1 - 3.6e-60 203.5 0.1 5e-60 203.1 0.1 1.1 1 0 0 1 1 1 1 Galactose-1-phosphate uridyl transferase, N-terminal domain GalP_UDP_tr_C PF02744.17 CCF33349.1 - 0.00097 18.9 0.8 0.0037 17.0 0.2 2.0 2 0 0 2 2 2 1 Galactose-1-phosphate uridyl transferase, C-terminal domain ZZ PF00569.17 CCF33350.1 - 2e-10 40.3 7.5 3.9e-10 39.4 7.5 1.4 1 0 0 1 1 1 1 Zinc finger, ZZ type Myb_DNA-binding PF00249.31 CCF33350.1 - 3e-09 36.9 0.2 2.3e-08 34.1 0.0 2.5 3 0 0 3 3 3 1 Myb-like DNA-binding domain SWIRM PF04433.17 CCF33350.1 - 1.1e-07 32.0 0.0 3.5e-07 30.5 0.0 1.8 1 0 0 1 1 1 1 SWIRM domain CEBP_ZZ PF16366.5 CCF33350.1 - 2 8.7 5.7 5 7.5 5.7 1.6 1 0 0 1 1 1 0 Cytoplasmic polyadenylation element-binding protein ZZ domain Dehydrin PF00257.19 CCF33351.1 - 1.2 9.7 6.5 2 8.9 6.5 1.4 1 0 0 1 1 1 0 Dehydrin COesterase PF00135.28 CCF33352.1 - 2.2e-78 264.4 0.0 2.8e-78 264.0 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CCF33352.1 - 0.033 14.1 0.1 0.1 12.4 0.1 1.8 1 1 0 1 1 1 0 alpha/beta hydrolase fold DUF3237 PF11578.8 CCF33353.1 - 1.2e-21 77.1 0.6 7.2e-16 58.4 0.1 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF3237) Tyrosinase PF00264.20 CCF33354.1 - 3.3e-46 158.4 2.5 8.1e-46 157.1 2.5 1.7 1 0 0 1 1 1 1 Common central domain of tyrosinase Tyosinase_C PF18132.1 CCF33354.1 - 0.0067 17.1 0.0 0.057 14.1 0.0 2.5 1 1 0 1 1 1 1 Tyosinase C-terminal domain Tannase PF07519.11 CCF33356.1 - 5.1e-34 118.0 4.9 6.6e-34 117.6 4.9 1.1 1 0 0 1 1 1 1 Tannase and feruloyl esterase Zn_clus PF00172.18 CCF33357.1 - 1.2e-07 31.7 10.9 1.2e-07 31.7 10.9 2.1 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 CCF33357.1 - 0.015 14.1 0.0 0.22 10.3 0.0 2.0 1 1 1 2 2 2 0 Fungal specific transcription factor domain Myosin_tail_1 PF01576.19 CCF33357.1 - 0.3 8.8 0.1 0.39 8.5 0.1 1.0 1 0 0 1 1 1 0 Myosin tail Glycos_transf_1 PF00534.20 CCF33359.1 - 1.5e-21 76.7 0.0 3.3e-21 75.6 0.0 1.6 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 CCF33359.1 - 1.5e-14 54.5 0.0 2.4e-14 53.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 CCF33359.1 - 0.001 19.4 0.0 0.0032 17.8 0.0 1.8 1 0 0 1 1 1 1 Glycosyl transferases group 1 RhoGEF PF00621.20 CCF33361.1 - 3.6e-32 112.1 0.0 9.1e-32 110.8 0.0 1.7 1 0 0 1 1 1 1 RhoGEF domain BAR PF03114.18 CCF33361.1 - 2.9e-10 40.2 0.0 7.1e-10 38.9 0.0 1.6 1 0 0 1 1 1 1 BAR domain LPD13 PF18825.1 CCF33361.1 - 0.0079 16.0 0.0 0.016 15.0 0.0 1.4 1 0 0 1 1 1 1 Large polyvalent protein-associated domain 13 Seryl_tRNA_N PF02403.22 CCF33361.1 - 0.56 10.5 3.0 20 5.5 0.4 2.7 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Velvet PF11754.8 CCF33362.1 - 1.9e-89 299.9 9.4 2.4e-88 296.3 9.4 2.1 1 1 0 1 1 1 1 Velvet factor W2 PF02020.18 CCF33365.1 - 1.2e-23 83.1 0.4 1.2e-23 83.1 0.4 2.2 4 0 0 4 4 4 1 eIF4-gamma/eIF5/eIF2-epsilon Cu-oxidase_2 PF07731.14 CCF33366.1 - 2.6e-40 137.3 10.3 1e-39 135.4 0.7 3.0 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 CCF33366.1 - 4.2e-37 126.8 2.1 4.2e-37 126.8 2.1 2.2 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase PF00394.22 CCF33366.1 - 4.4e-33 114.6 3.4 6.1e-32 110.9 1.0 2.6 2 0 0 2 2 2 1 Multicopper oxidase DUF5597 PF18120.1 CCF33367.1 - 0.32 11.1 3.1 53 3.9 0.0 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF5597) ADIP PF11559.8 CCF33367.1 - 2.6 8.1 16.3 3 7.9 15.3 1.5 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding UPF0242 PF06785.11 CCF33367.1 - 4 7.5 12.0 5.3 7.1 12.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus TBCC PF07986.12 CCF33368.1 - 1.8e-29 101.9 0.1 2.7e-29 101.3 0.1 1.3 1 0 0 1 1 1 1 Tubulin binding cofactor C TBCC_N PF16752.5 CCF33368.1 - 3.4e-11 43.6 0.0 6.5e-11 42.7 0.0 1.4 1 0 0 1 1 1 1 Tubulin-specific chaperone C N-terminal domain RTX PF02382.15 CCF33368.1 - 0.056 13.1 0.1 0.084 12.5 0.1 1.2 1 0 0 1 1 1 0 N-terminal domain in RTX protein T4SS PF07996.11 CCF33368.1 - 0.12 12.8 0.2 0.21 12.0 0.2 1.3 1 0 0 1 1 1 0 Type IV secretion system proteins Med9 PF07544.13 CCF33369.1 - 4.5e-21 74.7 1.4 7.5e-21 74.0 1.4 1.3 1 0 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 Spc29 PF17082.5 CCF33369.1 - 0.001 18.9 0.6 0.0014 18.5 0.6 1.1 1 0 0 1 1 1 1 Spindle Pole Component 29 Fib_alpha PF08702.10 CCF33369.1 - 0.0083 16.3 1.1 0.015 15.5 1.1 1.3 1 0 0 1 1 1 1 Fibrinogen alpha/beta chain family Formin_GBD_N PF18382.1 CCF33369.1 - 0.044 14.3 0.2 0.068 13.6 0.2 1.3 1 0 0 1 1 1 0 Formin N-terminal GTPase-binding domain Med21 PF11221.8 CCF33369.1 - 0.06 13.6 3.9 0.085 13.1 3.8 1.3 1 1 0 1 1 1 0 Subunit 21 of Mediator complex Phage_GP20 PF06810.11 CCF33369.1 - 0.074 12.9 0.2 0.11 12.3 0.2 1.2 1 0 0 1 1 1 0 Phage minor structural protein GP20 UPF0242 PF06785.11 CCF33369.1 - 0.12 12.4 2.5 0.16 12.1 2.5 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus BBP1_C PF15272.6 CCF33369.1 - 0.27 11.0 2.8 0.36 10.6 2.8 1.1 1 0 0 1 1 1 0 Spindle pole body component BBP1, C-terminal T3SS_needle_E PF08988.10 CCF33369.1 - 0.84 9.8 6.4 0.42 10.8 0.3 2.6 3 0 0 3 3 3 0 Type III secretion system, cytoplasmic E component of needle SlyX PF04102.12 CCF33369.1 - 1.1 10.0 9.6 1.1 9.9 5.4 2.6 2 1 1 3 3 3 0 SlyX iPGM_N PF06415.13 CCF33370.1 - 1.2e-75 253.7 0.0 1.7e-75 253.2 0.0 1.2 1 0 0 1 1 1 1 BPG-independent PGAM N-terminus (iPGM_N) Metalloenzyme PF01676.18 CCF33370.1 - 3.2e-61 206.8 0.0 4e-61 206.5 0.0 1.0 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.23 CCF33370.1 - 1.1e-07 31.5 0.0 1.3e-06 28.1 0.0 2.0 1 1 0 1 1 1 1 Sulfatase AP_endonuc_2 PF01261.24 CCF33370.1 - 0.038 13.4 0.0 0.088 12.2 0.0 1.5 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel DUF1877 PF08974.10 CCF33370.1 - 0.096 12.8 0.1 1.5 8.9 0.0 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF1877) Glyco_hydro_76 PF03663.14 CCF33371.1 - 2.6e-45 155.6 14.8 7.5e-45 154.0 14.8 1.6 1 1 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 CCF33371.1 - 3e-07 29.8 0.9 0.014 14.5 0.0 3.0 2 1 0 3 3 3 2 Glycosyl Hydrolase Family 88 C5-epim_C PF06662.13 CCF33371.1 - 0.0062 16.1 0.1 0.034 13.7 0.0 2.2 2 1 1 3 3 3 1 D-glucuronyl C5-epimerase C-terminus Glyco_hydro_127 PF07944.12 CCF33371.1 - 0.0073 14.9 0.1 0.61 8.5 0.1 2.2 1 1 1 2 2 2 2 Beta-L-arabinofuranosidase, GH127 fn3_3 PF14686.6 CCF33373.1 - 1.9e-27 94.8 1.7 4.4e-27 93.7 1.7 1.6 1 0 0 1 1 1 1 Polysaccharide lyase family 4, domain II CBM-like PF14683.6 CCF33373.1 - 2.2e-23 82.9 0.0 3.9e-23 82.1 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide lyase family 4, domain III CarboxypepD_reg PF13620.6 CCF33373.1 - 0.0078 16.5 0.1 0.024 14.9 0.1 1.8 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain Nudix_N PF12535.8 CCF33373.1 - 0.049 13.3 0.1 0.096 12.3 0.1 1.4 1 0 0 1 1 1 0 Hydrolase of X-linked nucleoside diphosphate N terminal DUF2220 PF09983.9 CCF33373.1 - 0.14 11.5 1.1 0.29 10.5 0.0 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria C-term(DUF2220) Phosphodiest PF01663.22 CCF33374.1 - 1.2e-09 38.3 2.8 3.6e-07 30.1 2.8 2.3 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.18 CCF33374.1 - 0.0017 17.8 0.2 0.003 17.0 0.2 1.3 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.23 CCF33374.1 - 0.0085 15.5 0.0 0.016 14.6 0.0 1.4 1 0 0 1 1 1 1 Sulfatase CPP1-like PF11833.8 CCF33374.1 - 0.033 13.8 3.3 0.05 13.3 2.6 1.6 1 1 0 1 1 1 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like DUF229 PF02995.17 CCF33374.1 - 0.19 10.3 0.1 0.27 9.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF229) DUF2423 PF10338.9 CCF33375.1 - 8.9e-19 67.4 3.2 8.9e-19 67.4 3.2 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF2423) HMG14_17 PF01101.18 CCF33375.1 - 0.042 14.8 2.7 0.042 14.8 2.7 2.5 1 1 1 2 2 2 0 HMG14 and HMG17 DUF3982 PF13138.6 CCF33375.1 - 0.065 13.0 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3982) TP53IP5 PF15331.6 CCF33375.1 - 1.1 9.4 8.4 1.1 9.4 8.4 1.1 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 PINIT PF14324.6 CCF33376.1 - 2.8e-42 144.5 0.4 5e-42 143.7 0.4 1.4 1 0 0 1 1 1 1 PINIT domain zf-MIZ PF02891.20 CCF33376.1 - 7.8e-23 80.0 5.8 2.1e-22 78.6 5.8 1.8 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 CCF33376.1 - 2.6e-06 27.1 1.6 6.5e-06 25.9 1.6 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit SAP PF02037.27 CCF33376.1 - 0.017 14.9 0.0 0.038 13.7 0.0 1.6 1 0 0 1 1 1 0 SAP domain zf-Sec23_Sec24 PF04810.15 CCF33376.1 - 0.051 13.6 2.4 0.089 12.9 0.7 2.3 2 1 0 2 2 2 0 Sec23/Sec24 zinc finger zf-C3HC4_4 PF15227.6 CCF33376.1 - 0.051 13.7 5.7 0.096 12.9 5.7 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 CCF33376.1 - 0.68 9.9 3.2 1.2 9.1 3.2 1.4 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_2 PF13639.6 CCF33376.1 - 0.94 9.9 4.7 1.9 8.9 4.7 1.5 1 0 0 1 1 1 0 Ring finger domain Fungal_trans PF04082.18 CCF33377.1 - 4.1e-30 104.7 0.0 8.7e-30 103.6 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF33377.1 - 1e-10 41.5 13.6 1.9e-10 40.7 13.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fer2 PF00111.27 CCF33377.1 - 0.067 13.2 2.8 1.6 8.7 0.0 2.5 2 0 0 2 2 2 0 2Fe-2S iron-sulfur cluster binding domain Gal4_dimer PF03902.13 CCF33377.1 - 0.091 12.9 0.1 0.4 10.9 0.1 2.1 1 0 0 1 1 1 0 Gal4-like dimerisation domain Spt20 PF12090.8 CCF33377.1 - 0.33 10.5 21.5 0.61 9.7 21.5 1.3 1 0 0 1 1 1 0 Spt20 family Presenilin PF01080.17 CCF33377.1 - 0.46 9.2 0.9 0.74 8.5 0.9 1.2 1 0 0 1 1 1 0 Presenilin Suf PF05843.14 CCF33377.1 - 0.7 9.8 7.5 0.29 11.1 4.8 1.6 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) DUF2722 PF10846.8 CCF33377.1 - 1.1 8.2 17.6 1.7 7.5 17.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Activator_LAG-3 PF11498.8 CCF33377.1 - 2.5 7.0 34.4 4.2 6.2 34.4 1.3 1 0 0 1 1 1 0 Transcriptional activator LAG-3 eIF-3_zeta PF05091.12 CCF33377.1 - 2.6 6.9 6.8 4.1 6.3 6.8 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Med3 PF11593.8 CCF33377.1 - 2.7 7.1 18.3 4.7 6.3 17.4 1.8 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal Sugarporin_N PF11471.8 CCF33377.1 - 4.3 7.4 4.9 9.6 6.2 0.7 2.8 2 0 0 2 2 2 0 Maltoporin periplasmic N-terminal extension DUF4834 PF16118.5 CCF33377.1 - 6.6 7.8 9.1 18 6.3 9.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DUF4175 PF13779.6 CCF33377.1 - 6.9 4.4 22.8 11 3.8 22.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Tautomerase_3 PF14832.6 CCF33378.1 - 2.4e-17 63.4 0.1 2.6e-17 63.3 0.1 1.0 1 0 0 1 1 1 1 Putative oxalocrotonate tautomerase enzyme Epimerase PF01370.21 CCF33379.1 - 1.8e-12 47.2 0.1 2.1e-08 34.0 0.0 2.5 2 1 0 2 2 2 2 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CCF33379.1 - 1.8e-09 37.8 0.0 3.4e-09 36.9 0.0 1.5 1 0 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 CCF33379.1 - 3.4e-08 32.8 0.0 3.7e-06 26.1 0.0 2.1 2 0 0 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family NmrA PF05368.13 CCF33379.1 - 4.6e-07 29.6 0.1 7.9e-07 28.9 0.1 1.6 1 1 0 1 1 1 1 NmrA-like family NAD_binding_4 PF07993.12 CCF33379.1 - 1.9e-06 27.2 0.0 0.00047 19.4 0.0 2.1 2 0 0 2 2 2 2 Male sterility protein GDP_Man_Dehyd PF16363.5 CCF33379.1 - 5.7e-06 26.0 0.0 1.1e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 CCF33379.1 - 2.4e-05 23.7 0.0 3.5e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.25 CCF33379.1 - 0.0016 17.9 0.0 0.0033 16.9 0.0 1.5 1 0 0 1 1 1 1 short chain dehydrogenase CFEM PF05730.11 CCF33380.1 - 4.2e-10 39.6 7.3 5.3e-10 39.3 7.3 1.2 1 0 0 1 1 1 1 CFEM domain Gamma-thionin PF00304.20 CCF33380.1 - 0.016 15.4 1.3 0.016 15.4 1.3 1.6 2 0 0 2 2 2 0 Gamma-thionin family LtrA PF06772.11 CCF33383.1 - 4.2e-24 85.4 13.2 5.3e-24 85.1 13.2 1.1 1 0 0 1 1 1 1 Bacterial low temperature requirement A protein (LtrA) COesterase PF00135.28 CCF33384.1 - 2.9e-88 297.0 0.1 4.1e-72 243.7 0.0 2.0 1 1 1 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.13 CCF33384.1 - 9.8e-05 22.3 0.0 0.00025 21.0 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CCF33384.1 - 0.084 12.3 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family Chromo_shadow PF01393.19 CCF33385.1 - 2.6e-19 69.1 2.4 3.9e-17 62.1 0.3 2.5 2 0 0 2 2 2 2 Chromo shadow domain Chromo PF00385.24 CCF33385.1 - 1.7e-13 50.2 1.8 1.7e-13 50.2 1.8 2.1 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain AT_hook PF02178.19 CCF33385.1 - 2.1 8.5 5.0 0.3 11.1 0.5 2.1 2 0 0 2 2 2 0 AT hook motif DNA_pol_phi PF04931.13 CCF33385.1 - 5.8 4.9 13.4 7.7 4.5 13.4 1.1 1 0 0 1 1 1 0 DNA polymerase phi COPI_assoc PF08507.10 CCF33386.1 - 0.0057 16.7 0.2 0.0069 16.4 0.2 1.1 1 0 0 1 1 1 1 COPI associated protein TRP PF06011.12 CCF33386.1 - 0.02 13.7 0.4 0.022 13.5 0.4 1.0 1 0 0 1 1 1 0 Transient receptor potential (TRP) ion channel DUF5326 PF17260.2 CCF33386.1 - 0.034 14.3 1.7 0.044 13.9 1.7 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5326) DPM3 PF08285.11 CCF33386.1 - 0.034 14.3 0.2 0.042 14.0 0.2 1.1 1 0 0 1 1 1 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) DUF4577 PF15145.6 CCF33386.1 - 0.046 13.8 0.1 0.046 13.8 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4577) DUF2749 PF10907.8 CCF33386.1 - 0.33 11.2 2.2 0.63 10.3 2.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2749) DUF4227 PF14004.6 CCF33386.1 - 0.53 10.3 1.9 0.72 9.9 1.9 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF4227) Syndecan PF01034.20 CCF33386.1 - 1.4 8.8 4.1 2.1 8.4 4.1 1.2 1 0 0 1 1 1 0 Syndecan domain FeoB_associated PF12669.7 CCF33386.1 - 4.9 7.6 5.9 8.8 6.8 5.9 1.4 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein 2Fe-2S_thioredx PF01257.19 CCF33389.1 - 3.8e-58 195.5 0.0 4.7e-58 195.2 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin Kelch_3 PF13415.6 CCF33390.1 - 7.3e-21 74.0 14.7 2.6e-05 24.4 0.1 7.3 8 0 0 8 8 8 5 Galactose oxidase, central domain Kelch_4 PF13418.6 CCF33390.1 - 6.9e-19 67.6 11.3 1.3e-06 28.3 0.1 6.5 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_6 PF13964.6 CCF33390.1 - 9.5e-19 67.0 0.3 2.3e-05 24.5 0.0 4.6 4 0 0 4 4 4 3 Kelch motif Kelch_5 PF13854.6 CCF33390.1 - 1.4e-14 53.7 5.7 0.0006 19.7 0.0 6.6 7 1 0 7 7 7 3 Kelch motif Kelch_1 PF01344.25 CCF33390.1 - 2.6e-14 52.5 9.0 2e-05 24.0 0.0 5.3 6 0 0 6 6 6 3 Kelch motif Kelch_2 PF07646.15 CCF33390.1 - 5.3e-13 48.4 3.5 6e-06 26.0 0.1 5.3 5 0 0 5 5 5 3 Kelch motif UQ_con PF00179.26 CCF33392.1 - 3.1e-31 107.9 0.0 4.1e-31 107.5 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 CCF33392.1 - 0.092 12.6 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 UEV domain Prok-E2_B PF14461.6 CCF33392.1 - 0.15 11.7 0.0 0.17 11.6 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B Anp1 PF03452.14 CCF33393.1 - 3.2e-110 367.7 0.0 3.7e-110 367.5 0.0 1.0 1 0 0 1 1 1 1 Anp1 Glycos_transf_2 PF00535.26 CCF33393.1 - 0.017 14.9 0.0 0.028 14.2 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferase family 2 zf-RING_UBOX PF13445.6 CCF33394.1 - 0.00024 21.1 12.0 0.00035 20.5 10.3 2.1 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 CCF33394.1 - 0.00073 19.8 10.0 0.0017 18.7 10.0 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 CCF33394.1 - 0.0097 15.7 6.7 0.019 14.8 6.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CCF33394.1 - 0.037 14.0 9.8 0.077 13.0 9.8 1.6 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4 PF00097.25 CCF33394.1 - 0.09 12.7 10.4 0.18 11.7 10.4 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) FYVE PF01363.21 CCF33394.1 - 0.12 12.5 6.0 0.34 11.1 6.0 1.7 1 0 0 1 1 1 0 FYVE zinc finger zf-C3HC4_4 PF15227.6 CCF33394.1 - 0.34 11.1 8.9 1.2 9.3 9.0 2.0 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING CorA PF01544.18 CCF33396.1 - 4.2e-14 52.5 0.3 5.6e-14 52.1 0.3 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein DDE_Tnp_ISL3 PF01610.17 CCF33396.1 - 0.037 13.7 0.1 0.059 13.1 0.1 1.3 1 0 0 1 1 1 0 Transposase K_channel_TID PF07941.11 CCF33396.1 - 0.1 13.0 0.2 0.22 12.0 0.2 1.5 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain Polysacc_synt_C PF14667.6 CCF33396.1 - 0.23 11.5 0.8 0.51 10.4 0.1 1.8 1 1 1 2 2 2 0 Polysaccharide biosynthesis C-terminal domain Pkinase PF00069.25 CCF33397.1 - 6.9e-51 173.1 0.0 9.4e-51 172.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF33397.1 - 3.3e-26 92.1 0.5 5.7e-25 88.1 0.3 2.3 2 1 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CCF33397.1 - 0.0022 16.8 0.1 0.015 14.1 0.0 2.1 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 CCF33397.1 - 0.019 14.3 0.0 0.032 13.6 0.0 1.3 1 0 0 1 1 1 0 Kinase-like FTA2 PF13095.6 CCF33397.1 - 0.19 11.3 0.4 7 6.2 0.0 2.2 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 DUF4112 PF13430.6 CCF33398.1 - 6.6e-35 119.6 0.3 8.6e-35 119.2 0.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4112) DCP2 PF05026.13 CCF33399.1 - 8.8e-31 106.1 0.5 8.8e-31 106.1 0.5 1.7 2 0 0 2 2 2 1 Dcp2, box A domain NUDIX PF00293.28 CCF33399.1 - 1.5e-15 57.4 0.1 2.6e-15 56.6 0.1 1.4 1 0 0 1 1 1 1 NUDIX domain DUF1100 PF06500.11 CCF33400.1 - 2.6e-11 43.0 0.0 3.3e-11 42.6 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1100) Peptidase_S15 PF02129.18 CCF33400.1 - 2.4e-06 27.3 0.0 4.2e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Esterase PF00756.20 CCF33400.1 - 2.7e-05 23.9 0.0 0.00035 20.3 0.0 2.1 1 1 0 1 1 1 1 Putative esterase Peptidase_S9 PF00326.21 CCF33400.1 - 4.2e-05 23.1 0.0 7.4e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 CCF33400.1 - 0.019 15.6 2.8 0.021 15.5 1.7 1.6 1 1 1 2 2 2 0 Alpha/beta hydrolase family Esterase_phd PF10503.9 CCF33400.1 - 0.022 14.3 0.2 0.054 13.0 0.0 1.7 2 0 0 2 2 2 0 Esterase PHB depolymerase Hydrolase_4 PF12146.8 CCF33400.1 - 0.075 12.3 0.0 0.31 10.2 0.0 1.8 1 1 1 2 2 2 0 Serine aminopeptidase, S33 Acetyltransf_1 PF00583.25 CCF33401.1 - 3.9e-11 43.2 0.0 5e-11 42.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CCF33401.1 - 8.2e-08 32.6 0.2 1.3e-07 32.0 0.2 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CCF33401.1 - 2.1e-06 27.7 0.0 2.8e-06 27.3 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain AstA PF04958.12 CCF33401.1 - 0.035 12.7 0.0 0.052 12.1 0.0 1.2 1 0 0 1 1 1 0 Arginine N-succinyltransferase beta subunit p450 PF00067.22 CCF33403.1 - 5.5e-13 48.5 0.0 6.7e-13 48.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 MFS_1 PF07690.16 CCF33404.1 - 5e-27 94.8 15.6 5.6e-27 94.6 15.6 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF33404.1 - 2.3e-09 36.6 13.3 3.7e-09 36.0 13.3 1.2 1 1 0 1 1 1 1 Sugar (and other) transporter RabGAP-TBC PF00566.18 CCF33405.1 - 1.7e-19 70.3 0.0 6.8e-19 68.4 0.0 1.9 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Vps52 PF04129.12 CCF33406.1 - 4.3e-115 385.4 0.2 5.6e-115 385.0 0.2 1.0 1 0 0 1 1 1 1 Vps52 / Sac2 family Sec3_C PF09763.9 CCF33406.1 - 3.9e-06 25.6 5.1 5.4e-05 21.8 5.1 2.0 1 1 0 1 1 1 1 Exocyst complex component Sec3 Filament PF00038.21 CCF33406.1 - 0.057 13.0 2.7 0.18 11.4 0.1 2.2 2 0 0 2 2 2 0 Intermediate filament protein CENP-F_leu_zip PF10473.9 CCF33406.1 - 0.19 11.7 0.8 0.34 10.9 0.1 1.7 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Mer2 PF09074.10 CCF33406.1 - 0.32 10.8 2.4 3.1 7.6 0.1 2.4 2 0 0 2 2 2 0 Mer2 THOC7 PF05615.13 CCF33406.1 - 1.3 9.3 4.6 0.67 10.2 0.4 2.6 3 0 0 3 3 3 0 Tho complex subunit 7 Lyase_1 PF00206.20 CCF33407.1 - 8.8e-19 68.0 0.0 1.6e-18 67.2 0.0 1.3 1 0 0 1 1 1 1 Lyase ADSL_C PF10397.9 CCF33407.1 - 3.4e-17 62.8 0.1 1.4e-16 60.7 0.0 2.2 2 0 0 2 2 2 1 Adenylosuccinate lyase C-terminus DUF1748 PF08520.10 CCF33408.1 - 0.021 14.7 0.0 0.081 12.8 0.0 2.1 1 1 0 1 1 1 0 Fungal protein of unknown function (DUF1748) PHO4 PF01384.20 CCF33409.1 - 1.1e-113 379.7 20.2 1.3e-113 379.5 20.2 1.0 1 0 0 1 1 1 1 Phosphate transporter family adh_short PF00106.25 CCF33411.1 - 9.6e-15 54.6 0.1 1.2e-14 54.2 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF33411.1 - 2.6e-13 50.1 0.0 3e-13 49.9 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NmrA PF05368.13 CCF33411.1 - 3.2e-06 26.9 0.5 5.5e-06 26.1 0.5 1.3 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CCF33411.1 - 2.5e-05 24.3 0.7 4.1e-05 23.6 0.7 1.3 1 0 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 CCF33411.1 - 0.00037 20.4 0.0 0.00043 20.2 0.0 1.2 1 0 0 1 1 1 1 KR domain PALP PF00291.25 CCF33411.1 - 0.016 14.6 0.1 0.023 14.1 0.1 1.3 1 0 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme Epimerase PF01370.21 CCF33411.1 - 0.043 13.3 0.0 0.069 12.6 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family DapB_N PF01113.20 CCF33411.1 - 0.073 13.2 0.3 0.26 11.4 0.1 1.8 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus Eno-Rase_NADH_b PF12242.8 CCF33411.1 - 0.15 11.8 0.3 0.26 11.1 0.3 1.4 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Vps4_C PF09336.10 CCF33412.1 - 6.8e-11 42.0 0.0 6e-09 35.8 0.0 2.2 2 0 0 2 2 2 2 Vps4 C terminal oligomerisation domain AAA_lid_3 PF17862.1 CCF33412.1 - 9.9e-06 25.3 0.0 1.7e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 AAA+ lid domain Ribosomal_S17 PF00366.20 CCF33413.1 - 3.4e-21 75.1 0.6 3.4e-21 75.1 0.6 1.5 2 0 0 2 2 2 1 Ribosomal protein S17 EMG1 PF03587.14 CCF33414.1 - 8.7e-79 263.7 0.0 1e-78 263.5 0.0 1.0 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase AMP-binding PF00501.28 CCF33415.1 - 1.6e-82 277.4 0.0 2.2e-82 276.9 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CCF33415.1 - 0.028 15.4 0.4 0.13 13.3 0.2 2.3 1 1 1 2 2 2 0 AMP-binding enzyme C-terminal domain KH_1 PF00013.29 CCF33416.1 - 1.5e-91 300.2 31.6 4.2e-14 52.1 0.1 13.5 15 0 0 15 15 15 10 KH domain KH_2 PF07650.17 CCF33416.1 - 2.5e-11 43.2 24.3 0.022 14.6 0.3 7.2 6 1 0 7 7 7 4 KH domain SLS PF14611.6 CCF33416.1 - 5.9e-11 42.6 5.9 0.15 11.8 0.0 7.3 4 2 4 9 9 9 4 Mitochondrial inner-membrane-bound regulator KH_4 PF13083.6 CCF33416.1 - 0.028 14.3 9.4 0.16 11.9 0.3 5.3 6 0 0 6 6 6 0 KH domain DUF5300 PF17224.3 CCF33416.1 - 1.1 9.6 6.6 72 3.7 0.1 4.8 5 0 0 5 5 5 0 Domain of unknown function (DUF5300) BON PF04972.17 CCF33416.1 - 2.5 8.5 12.5 6.9 7.1 0.0 4.6 5 0 0 5 5 5 0 BON domain Fungal_trans PF04082.18 CCF33417.1 - 3.2e-22 78.8 0.3 4.8e-22 78.3 0.3 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF33417.1 - 5.6e-05 23.2 8.3 0.00012 22.2 8.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 CCF33417.1 - 0.052 12.4 0.2 0.083 11.7 0.2 1.4 1 0 0 1 1 1 0 Fungal specific transcription factor domain Utp14 PF04615.13 CCF33418.1 - 3.2 6.2 11.2 3.5 6.1 11.2 1.1 1 0 0 1 1 1 0 Utp14 protein SOG2 PF10428.9 CCF33418.1 - 4.6 6.3 9.1 5.5 6.1 9.1 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Macoilin PF09726.9 CCF33418.1 - 5.4 5.5 13.2 7 5.1 13.2 1.1 1 0 0 1 1 1 0 Macoilin family Presenilin PF01080.17 CCF33418.1 - 8.7 5.0 11.0 13 4.4 11.0 1.2 1 0 0 1 1 1 0 Presenilin TrkH PF02386.16 CCF33419.1 - 3.9e-28 98.2 3.2 1.8e-25 89.3 0.7 2.1 2 0 0 2 2 2 2 Cation transport protein TFCD_C PF12612.8 CCF33420.1 - 1.3e-28 100.1 0.5 4.7e-28 98.3 0.2 2.2 2 0 0 2 2 2 1 Tubulin folding cofactor D C terminal HEAT PF02985.22 CCF33420.1 - 0.0037 17.4 2.2 1.5 9.3 0.0 5.1 5 0 0 5 5 5 1 HEAT repeat HEAT_2 PF13646.6 CCF33420.1 - 0.0042 17.5 6.2 0.48 10.8 0.2 5.0 4 0 0 4 4 4 1 HEAT repeats IFRD PF05004.13 CCF33420.1 - 0.13 11.4 1.4 2.1 7.4 0.2 2.5 2 0 0 2 2 2 0 Interferon-related developmental regulator (IFRD) Peptidase_C12 PF01088.21 CCF33424.1 - 1.1e-62 211.6 0.0 1.5e-62 211.1 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 Transglut_core2 PF13369.6 CCF33425.1 - 2.8e-18 66.0 0.0 6.8e-18 64.7 0.0 1.7 1 0 0 1 1 1 1 Transglutaminase-like superfamily F-box-like PF12937.7 CCF33425.1 - 7.4e-08 32.2 1.4 2.6e-07 30.4 1.6 1.9 2 0 0 2 2 2 1 F-box-like YccV-like PF08755.11 CCF33425.1 - 0.00029 21.3 1.5 0.0084 16.6 1.5 2.6 1 1 0 1 1 1 1 Hemimethylated DNA-binding protein YccV like F-box PF00646.33 CCF33425.1 - 0.00092 19.0 0.3 0.0025 17.6 0.3 1.8 1 0 0 1 1 1 1 F-box domain DUF2868 PF11067.8 CCF33425.1 - 0.049 13.1 0.9 0.076 12.5 0.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2868) Cnn_1N PF07989.11 CCF33426.1 - 5.9e-21 74.4 0.9 9.1e-21 73.8 0.9 1.3 1 0 0 1 1 1 1 Centrosomin N-terminal motif 1 EthD PF07110.11 CCF33427.1 - 0.0002 22.5 0.0 0.00037 21.6 0.0 1.4 1 1 0 1 1 1 1 EthD domain Sugar_tr PF00083.24 CCF33428.1 - 2.4e-127 425.5 28.5 2.8e-127 425.3 28.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF33428.1 - 5.8e-20 71.5 39.2 6.2e-12 45.1 15.4 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily TauD PF02668.16 CCF33429.1 - 1.3e-08 35.0 0.5 1.5e-08 34.8 0.5 1.0 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family AAA_5 PF07728.14 CCF33430.1 - 1.8e-122 403.8 0.0 2e-21 76.5 0.0 9.8 9 0 0 9 9 9 9 AAA domain (dynein-related subfamily) AAA_lid_7 PF17867.1 CCF33430.1 - 1.5e-53 179.5 2.0 1.5e-21 76.6 0.0 5.2 4 0 0 4 4 4 3 Midasin AAA lid domain AAA_lid_5 PF17865.1 CCF33430.1 - 2.9e-33 114.1 0.4 5.3e-32 110.1 0.0 2.9 2 0 0 2 2 2 1 Midasin AAA lid domain AAA_3 PF07726.11 CCF33430.1 - 2.8e-29 101.6 0.0 9.7e-10 38.4 0.0 7.3 7 0 0 7 7 6 3 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 CCF33430.1 - 3.3e-29 101.7 3.3 1.2e-05 24.9 0.1 7.1 6 1 0 6 6 6 6 P-loop containing dynein motor region AAA PF00004.29 CCF33430.1 - 8.3e-29 100.7 0.1 0.00031 21.2 0.0 7.0 6 0 0 6 6 6 5 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CCF33430.1 - 1.7e-26 93.6 18.8 0.00035 21.0 0.0 9.3 7 2 0 7 7 6 6 AAA ATPase domain Dynein_heavy PF03028.15 CCF33430.1 - 3.9e-24 85.0 0.0 0.0057 16.7 0.0 8.2 7 1 0 7 7 7 4 Dynein heavy chain region D6 P-loop domain AAA_22 PF13401.6 CCF33430.1 - 1.4e-21 77.2 1.1 0.0053 17.0 0.0 7.6 6 0 0 6 6 6 4 AAA domain AAA_6 PF12774.7 CCF33430.1 - 3.2e-21 75.7 0.1 0.0076 15.3 0.0 8.9 8 1 0 8 8 8 5 Hydrolytic ATP binding site of dynein motor region Sigma54_activat PF00158.26 CCF33430.1 - 2e-19 69.9 0.0 0.061 13.0 0.0 6.9 7 0 0 7 7 6 5 Sigma-54 interaction domain AAA_18 PF13238.6 CCF33430.1 - 8.8e-18 65.1 0.7 0.038 14.5 0.0 6.8 6 0 0 6 6 6 3 AAA domain AAA_33 PF13671.6 CCF33430.1 - 1.8e-17 63.9 0.1 0.021 15.0 0.0 7.9 7 1 0 7 7 7 4 AAA domain TsaE PF02367.17 CCF33430.1 - 3.6e-16 59.3 3.7 0.0049 16.9 0.2 6.7 6 0 0 6 6 6 4 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 CCF33430.1 - 1.8e-15 57.1 0.0 0.014 15.4 0.0 7.2 7 0 0 7 7 6 3 AAA domain ABC_tran PF00005.27 CCF33430.1 - 2.1e-15 57.4 2.2 0.081 13.4 0.0 7.3 6 1 0 6 6 6 2 ABC transporter AAA_30 PF13604.6 CCF33430.1 - 2e-14 53.7 0.0 0.086 12.6 0.0 7.6 6 1 0 6 6 6 2 AAA domain T2SSE PF00437.20 CCF33430.1 - 4.8e-14 52.1 4.3 0.034 13.2 0.0 6.5 6 0 0 6 6 6 3 Type II/IV secretion system protein RNA_helicase PF00910.22 CCF33430.1 - 4.9e-14 52.6 0.8 0.55 10.6 0.0 6.6 6 0 0 6 6 6 3 RNA helicase RuvB_N PF05496.12 CCF33430.1 - 1.6e-13 50.7 1.9 0.03 14.1 0.0 6.3 6 0 0 6 6 5 3 Holliday junction DNA helicase RuvB P-loop domain NACHT PF05729.12 CCF33430.1 - 3.5e-13 49.8 8.1 0.067 13.1 0.1 6.4 7 0 0 7 7 5 4 NACHT domain RsgA_GTPase PF03193.16 CCF33430.1 - 1e-11 45.1 1.4 0.65 9.9 0.1 6.6 6 0 0 6 6 6 2 RsgA GTPase AAA_25 PF13481.6 CCF33430.1 - 1.8e-11 44.0 3.4 0.63 9.6 0.0 5.8 5 0 0 5 5 5 4 AAA domain Mg_chelatase PF01078.21 CCF33430.1 - 2.8e-11 43.2 4.8 6.9 6.0 0.0 9.2 10 0 0 10 10 9 0 Magnesium chelatase, subunit ChlI AAA_29 PF13555.6 CCF33430.1 - 3.4e-11 42.7 0.7 0.19 11.5 0.0 6.5 6 0 0 6 6 6 1 P-loop containing region of AAA domain AAA_28 PF13521.6 CCF33430.1 - 8.9e-11 42.3 3.8 0.53 10.5 0.0 6.9 6 0 0 6 6 6 2 AAA domain Sigma54_activ_2 PF14532.6 CCF33430.1 - 1.1e-10 41.8 0.4 0.0065 16.6 0.0 6.1 6 0 0 6 6 5 2 Sigma-54 interaction domain Rad17 PF03215.15 CCF33430.1 - 2.7e-10 40.5 1.8 0.34 10.8 0.0 6.5 6 0 0 6 6 6 2 Rad17 P-loop domain IstB_IS21 PF01695.17 CCF33430.1 - 1.1e-09 38.3 0.3 0.5 10.1 0.0 6.4 6 0 0 6 6 6 1 IstB-like ATP binding protein Zeta_toxin PF06414.12 CCF33430.1 - 3.2e-09 36.4 7.4 0.082 12.2 0.0 7.1 8 0 0 8 8 6 1 Zeta toxin AAA_19 PF13245.6 CCF33430.1 - 1.2e-08 35.4 3.5 4.1 7.7 0.0 6.7 6 0 0 6 6 5 0 AAA domain AAA_23 PF13476.6 CCF33430.1 - 2.5e-08 34.7 6.4 0.69 10.4 0.1 7.0 7 0 0 7 7 6 2 AAA domain NTPase_1 PF03266.15 CCF33430.1 - 2.7e-08 33.9 6.4 1.1 9.1 0.0 7.0 6 0 0 6 6 6 2 NTPase ATPase_2 PF01637.18 CCF33430.1 - 6.1e-08 32.9 0.0 1.2 9.0 0.0 6.6 6 0 0 6 6 6 1 ATPase domain predominantly from Archaea SRP54 PF00448.22 CCF33430.1 - 7.7e-08 32.2 1.5 0.54 9.8 0.1 5.0 5 0 0 5 5 5 1 SRP54-type protein, GTPase domain AAA_24 PF13479.6 CCF33430.1 - 1.7e-07 31.2 0.8 1.4 8.6 0.1 6.3 6 1 0 6 6 6 1 AAA domain AAA_2 PF07724.14 CCF33430.1 - 4.3e-07 30.2 0.0 2 8.5 0.0 5.9 5 0 0 5 5 5 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 CCF33430.1 - 7.3e-07 28.6 2.0 0.59 9.2 0.0 5.2 5 0 0 5 5 5 1 Protein of unknown function (DUF815) PduV-EutP PF10662.9 CCF33430.1 - 1e-06 28.6 2.8 0.086 12.6 0.0 5.0 5 0 0 5 5 5 2 Ethanolamine utilisation - propanediol utilisation Viral_helicase1 PF01443.18 CCF33430.1 - 5e-06 26.4 0.3 0.37 10.5 0.0 5.6 6 0 0 6 6 5 1 Viral (Superfamily 1) RNA helicase TniB PF05621.11 CCF33430.1 - 6.1e-06 25.8 0.9 9.7 5.5 0.0 6.2 7 0 0 7 7 6 0 Bacterial TniB protein CbiA PF01656.23 CCF33430.1 - 1.3e-05 25.3 0.0 1.5 8.9 0.0 5.1 5 1 0 5 5 4 1 CobQ/CobB/MinD/ParA nucleotide binding domain MMR_HSR1 PF01926.23 CCF33430.1 - 1.3e-05 25.2 0.5 39 4.4 0.0 6.2 5 0 0 5 5 5 0 50S ribosome-binding GTPase dNK PF01712.19 CCF33430.1 - 1.4e-05 25.0 3.8 16 5.3 0.0 5.7 5 0 0 5 5 5 0 Deoxynucleoside kinase NB-ARC PF00931.22 CCF33430.1 - 2.1e-05 23.9 3.4 1.6 7.8 0.0 5.6 5 0 0 5 5 5 1 NB-ARC domain TIP49 PF06068.13 CCF33430.1 - 2.6e-05 23.6 0.4 1.9 7.6 0.0 4.8 5 0 0 5 5 5 1 TIP49 P-loop domain ResIII PF04851.15 CCF33430.1 - 8.4e-05 22.6 0.2 13 5.8 0.1 5.5 6 0 0 6 6 5 0 Type III restriction enzyme, res subunit cobW PF02492.19 CCF33430.1 - 9.7e-05 22.0 6.5 2 7.9 0.0 5.6 6 0 0 6 6 6 1 CobW/HypB/UreG, nucleotide-binding domain AAA_17 PF13207.6 CCF33430.1 - 0.00012 22.6 3.9 11 6.5 0.0 5.7 5 0 0 5 5 5 0 AAA domain Roc PF08477.13 CCF33430.1 - 0.00021 21.5 5.0 6.7 6.9 0.1 5.8 6 0 0 6 6 5 0 Ras of Complex, Roc, domain of DAPkinase ATPase PF06745.13 CCF33430.1 - 0.00022 20.7 4.9 8.9 5.6 0.0 5.8 6 0 0 6 6 5 0 KaiC AAA_9 PF12781.7 CCF33430.1 - 0.00044 19.4 0.0 0.095 11.8 0.0 4.1 4 1 1 5 5 4 1 ATP-binding dynein motor region Thymidylate_kin PF02223.17 CCF33430.1 - 0.00057 19.6 1.0 36 3.9 0.0 5.9 6 0 0 6 6 5 0 Thymidylate kinase ATP_bind_1 PF03029.17 CCF33430.1 - 0.00059 19.7 3.9 19 5.0 0.0 5.7 6 0 0 6 6 6 0 Conserved hypothetical ATP binding protein CPT PF07931.12 CCF33430.1 - 0.00064 19.6 4.6 28 4.5 0.0 7.0 8 1 0 8 8 4 0 Chloramphenicol phosphotransferase-like protein KAP_NTPase PF07693.14 CCF33430.1 - 0.0018 17.5 0.0 6.6 5.9 0.0 5.4 6 0 0 6 6 5 0 KAP family P-loop domain KTI12 PF08433.10 CCF33430.1 - 0.0023 17.4 0.1 0.37 10.2 0.0 4.2 4 0 0 4 4 4 1 Chromatin associated protein KTI12 Bac_DnaA PF00308.18 CCF33430.1 - 0.0024 17.8 0.7 23 4.7 0.1 4.9 5 0 0 5 5 4 0 Bacterial dnaA protein DnaB_C PF03796.15 CCF33430.1 - 0.003 16.9 0.6 0.45 9.8 0.0 3.6 4 0 0 4 4 2 1 DnaB-like helicase C terminal domain MeaB PF03308.16 CCF33430.1 - 0.0034 16.4 1.8 9.1 5.2 0.0 3.8 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB DAP3 PF10236.9 CCF33430.1 - 0.01 15.0 5.5 2.6 7.1 0.0 4.8 5 0 0 5 5 5 0 Mitochondrial ribosomal death-associated protein 3 AAA_8 PF12780.7 CCF33430.1 - 0.011 15.1 0.1 12 5.1 0.0 4.5 5 0 0 5 5 4 0 P-loop containing dynein motor region D4 SRPRB PF09439.10 CCF33430.1 - 0.016 14.7 1.7 13 5.1 0.0 4.8 6 0 0 6 6 4 0 Signal recognition particle receptor beta subunit PRK PF00485.18 CCF33430.1 - 0.017 14.9 0.2 30 4.3 0.0 4.5 6 0 0 6 6 3 0 Phosphoribulokinase / Uridine kinase family GAF_2 PF13185.6 CCF33430.1 - 0.017 15.4 0.0 0.33 11.2 0.0 3.3 4 0 0 4 4 1 0 GAF domain Ploopntkinase3 PF18751.1 CCF33430.1 - 0.022 14.7 0.2 18 5.1 0.0 4.1 4 0 0 4 4 4 0 P-loop Nucleotide Kinase3 DEAD PF00270.29 CCF33430.1 - 0.03 14.1 0.5 13 5.5 0.0 3.9 4 0 0 4 4 3 0 DEAD/DEAH box helicase PhoH PF02562.16 CCF33430.1 - 0.14 11.6 0.1 31 3.9 0.0 4.3 5 0 0 5 5 4 0 PhoH-like protein tRNA_lig_kinase PF08303.11 CCF33430.1 - 0.14 12.2 0.9 1.1 9.4 0.2 2.7 2 0 0 2 2 2 0 tRNA ligase kinase domain SKI PF01202.22 CCF33430.1 - 0.15 12.2 1.0 85 3.2 0.0 4.4 4 0 0 4 4 3 0 Shikimate kinase TrbI_Ftype PF09677.10 CCF33430.1 - 0.31 11.4 2.3 1.4 9.3 0.0 3.4 3 0 0 3 3 1 0 Type-F conjugative transfer system protein (TrbI_Ftype) MobB PF03205.14 CCF33430.1 - 0.77 9.7 5.1 76 3.2 0.1 5.2 6 0 0 6 6 5 0 Molybdopterin guanine dinucleotide synthesis protein B Apolipoprotein PF01442.18 CCF33430.1 - 0.92 9.4 18.2 1 9.2 1.7 4.2 4 0 0 4 4 3 0 Apolipoprotein A1/A4/E domain Ribosomal_L12 PF00542.19 CCF33431.1 - 2.2e-21 76.0 9.4 1.7e-20 73.1 6.7 2.4 2 0 0 2 2 2 1 Ribosomal protein L7/L12 C-terminal domain Ribosomal_L12_N PF16320.5 CCF33431.1 - 7.4e-12 44.8 18.6 2.6e-10 39.8 17.9 3.1 1 1 0 1 1 1 1 Ribosomal protein L7/L12 dimerisation domain Methyltransf_34 PF11312.8 CCF33431.1 - 0.049 12.9 0.3 0.05 12.8 0.3 1.1 1 0 0 1 1 1 0 Putative SAM-dependent methyltransferase Ribosomal_60s PF00428.19 CCF33431.1 - 3.2 8.4 17.0 0.084 13.5 9.2 2.3 1 1 1 2 2 2 0 60s Acidic ribosomal protein CTK3 PF12243.8 CCF33432.1 - 3e-51 172.6 0.6 4.4e-51 172.0 0.6 1.2 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 CTK3_C PF12350.8 CCF33432.1 - 2.4e-20 72.5 9.8 2.4e-20 72.5 9.8 2.0 2 0 0 2 2 2 1 CTD kinase subunit gamma CTK3 C-terminus Rcd1 PF04078.13 CCF33432.1 - 0.0064 15.8 0.0 0.011 15.1 0.0 1.3 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like P5CR_dimer PF14748.6 CCF33433.1 - 2.3e-36 124.1 2.9 4.9e-36 123.1 2.9 1.6 1 0 0 1 1 1 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 CCF33433.1 - 9.6e-13 48.5 0.8 7.3e-11 42.5 0.0 2.6 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent SNF2_N PF00176.23 CCF33434.1 - 6.3e-53 179.7 0.0 1.1e-52 178.9 0.0 1.3 1 1 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.15 CCF33434.1 - 0.00084 19.4 0.0 0.001 19.1 0.0 1.2 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SWI2_SNF2 PF18766.1 CCF33434.1 - 0.008 15.9 0.0 0.015 15.0 0.0 1.5 1 1 0 1 1 1 1 SWI2/SNF2 ATPase GEN1_C PF18380.1 CCF33434.1 - 0.03 15.2 0.1 0.054 14.4 0.1 1.4 1 0 0 1 1 1 0 Holliday junction resolvase Gen1 C-terminal domain IGR PF09597.10 CCF33435.1 - 1.4e-24 85.9 0.1 3.3e-24 84.7 0.1 1.7 1 0 0 1 1 1 1 IGR protein motif Glyco_hydro_12 PF01670.16 CCF33436.1 - 4.6e-21 75.8 4.9 1.2e-17 64.6 0.8 2.1 2 0 0 2 2 2 2 Glycosyl hydrolase family 12 Proteasom_PSMB PF10508.9 CCF33436.1 - 0.064 11.8 0.0 0.089 11.3 0.0 1.1 1 0 0 1 1 1 0 Proteasome non-ATPase 26S subunit M20_dimer PF07687.14 CCF33437.1 - 4.2e-07 29.9 0.1 1.1e-06 28.5 0.1 1.7 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M20 PF01546.28 CCF33437.1 - 1.1e-05 25.2 0.0 1.7e-05 24.7 0.0 1.4 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 LEA_6 PF10714.9 CCF33437.1 - 0.068 13.2 0.1 0.28 11.3 0.1 2.0 1 0 0 1 1 1 0 Late embryogenesis abundant protein 18 p450 PF00067.22 CCF33438.1 - 2.7e-34 118.7 0.0 9e-34 117.0 0.0 1.8 1 1 0 1 1 1 1 Cytochrome P450 ComX PF05952.12 CCF33438.1 - 0.19 11.7 0.0 0.4 10.6 0.0 1.5 1 0 0 1 1 1 0 Bacillus competence pheromone ComX Man-6-P_recep PF02157.15 CCF33439.1 - 1.1e-16 60.8 0.0 9.6e-16 57.6 0.0 2.0 1 1 0 2 2 2 1 Mannose-6-phosphate receptor ATG27 PF09451.10 CCF33439.1 - 3.8e-14 53.2 0.0 1.5e-13 51.2 0.0 2.0 1 1 0 1 1 1 1 Autophagy-related protein 27 CIMR PF00878.18 CCF33439.1 - 3.2e-09 37.0 0.1 4e-05 23.7 0.0 2.3 2 0 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat Sugar_tr PF00083.24 CCF33440.1 - 2.2e-93 313.6 21.8 2.5e-93 313.4 21.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF33440.1 - 6.9e-36 123.9 47.9 2.2e-31 109.1 22.0 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily DEAD PF00270.29 CCF33441.1 - 1.2e-39 135.8 0.1 2e-39 135.2 0.1 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF33441.1 - 1.6e-31 108.9 0.6 1.6e-29 102.5 0.0 2.7 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCF33441.1 - 4e-08 33.5 0.0 8.6e-08 32.4 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit GNAT_acetyltran PF12746.7 CCF33441.1 - 0.026 14.1 0.2 0.53 9.8 0.1 2.4 2 0 0 2 2 2 0 GNAT acetyltransferase AAA_19 PF13245.6 CCF33441.1 - 0.029 14.7 0.0 0.047 14.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain Methyltransf_23 PF13489.6 CCF33442.1 - 1.7e-11 44.2 0.0 2.1e-11 43.9 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF33442.1 - 7e-11 42.7 0.0 1e-10 42.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF33442.1 - 2.2e-09 37.9 0.0 3.3e-09 37.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF33442.1 - 2e-08 34.7 0.0 3.5e-08 34.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF33442.1 - 2e-05 24.4 0.0 2.9e-05 23.9 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_33 PF10017.9 CCF33442.1 - 0.28 10.3 0.0 0.39 9.8 0.0 1.1 1 0 0 1 1 1 0 Histidine-specific methyltransferase, SAM-dependent Sugar_tr PF00083.24 CCF33443.1 - 8.4e-85 285.3 16.2 9.5e-85 285.1 16.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF33443.1 - 1.6e-12 47.1 36.6 7.6e-12 44.8 33.8 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily WD40 PF00400.32 CCF33444.1 - 1e-12 48.3 3.4 0.32 11.9 0.0 6.6 5 1 1 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF33444.1 - 0.025 14.9 0.0 8.9 6.7 0.0 3.7 2 1 2 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 CCF33444.1 - 0.13 12.3 0.7 1.3 9.1 0.1 2.9 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat AAA_11 PF13086.6 CCF33445.1 - 1.2e-12 48.2 0.1 1.7e-12 47.7 0.1 1.2 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CCF33445.1 - 9.9e-06 25.4 0.0 1.6e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CCF33445.1 - 0.00036 20.9 0.0 0.00081 19.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain PhoH PF02562.16 CCF33445.1 - 0.0083 15.6 0.0 0.014 14.8 0.0 1.3 1 0 0 1 1 1 1 PhoH-like protein IstB_IS21 PF01695.17 CCF33445.1 - 0.045 13.5 0.0 0.084 12.6 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein T2SSE PF00437.20 CCF33445.1 - 0.073 12.1 0.0 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_33 PF13671.6 CCF33445.1 - 0.08 13.1 0.1 1.4 9.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.9 CCF33445.1 - 0.21 10.8 0.0 0.58 9.3 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA PF00004.29 CCF33445.1 - 0.35 11.3 1.3 2.7 8.4 0.5 2.3 2 1 1 3 3 3 0 ATPase family associated with various cellular activities (AAA) Pex24p PF06398.11 CCF33446.1 - 3.6e-77 259.8 0.0 4.5e-77 259.5 0.0 1.0 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin Syntaxin-18_N PF10496.9 CCF33446.1 - 0.15 12.4 0.7 0.31 11.3 0.0 1.8 2 0 0 2 2 2 0 SNARE-complex protein Syntaxin-18 N-terminus RabGAP-TBC PF00566.18 CCF33448.1 - 7.9e-33 113.9 0.0 1.2e-32 113.4 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF3995 PF13160.6 CCF33450.1 - 0.034 14.5 6.6 0.041 14.2 6.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3995) Exo_endo_phos PF03372.23 CCF33451.1 - 1.2e-16 60.9 0.2 3.1e-15 56.3 0.0 2.5 2 1 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family LRR_4 PF12799.7 CCF33451.1 - 1.4e-07 31.7 3.0 0.00036 20.9 0.1 2.6 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCF33451.1 - 2.6e-07 30.3 9.1 3.1e-06 26.8 0.4 2.4 1 1 1 2 2 2 2 Leucine rich repeat LRR_6 PF13516.6 CCF33451.1 - 0.14 12.3 1.1 0.45 10.7 0.0 2.5 2 0 0 2 2 2 0 Leucine Rich repeat TFIIA PF03153.13 CCF33451.1 - 0.44 10.5 7.6 0.68 9.9 7.6 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Fungal_trans_2 PF11951.8 CCF33452.1 - 0.00015 20.7 0.3 0.0015 17.5 0.3 2.1 1 1 0 1 1 1 1 Fungal specific transcription factor domain p450 PF00067.22 CCF33453.1 - 1.1e-48 166.2 0.0 1.5e-48 165.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 polyprenyl_synt PF00348.17 CCF33454.1 - 6.4e-39 133.5 0.1 1.5e-38 132.3 0.1 1.5 1 0 0 1 1 1 1 Polyprenyl synthetase TPR_12 PF13424.6 CCF33454.1 - 0.011 16.0 1.5 8 6.8 0.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat MFS_1 PF07690.16 CCF33455.1 - 7e-39 133.7 27.1 7e-39 133.7 27.1 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily YfmQ PF10787.9 CCF33455.1 - 0.071 12.9 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein from bacillus cereus group Aminotran_1_2 PF00155.21 CCF33456.1 - 4.7e-44 151.0 0.0 5.5e-44 150.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_3 PF00202.21 CCF33456.1 - 0.2 10.3 0.0 0.32 9.6 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class-III RNA_pol_Rpc4 PF05132.14 CCF33457.1 - 4.7e-33 114.7 1.7 2.4e-32 112.4 0.0 2.8 3 0 0 3 3 3 1 RNA polymerase III RPC4 UreD PF01774.17 CCF33458.1 - 1.9e-73 246.9 0.0 2.3e-73 246.6 0.0 1.1 1 0 0 1 1 1 1 UreD urease accessory protein STAG PF08514.11 CCF33459.1 - 8e-34 115.9 1.6 2.1e-33 114.6 0.4 2.4 2 0 0 2 2 2 1 STAG domain HEAT_2 PF13646.6 CCF33459.1 - 4.3e-05 23.8 0.0 0.13 12.7 0.0 3.8 3 0 0 3 3 3 2 HEAT repeats Cnd1 PF12717.7 CCF33459.1 - 0.00044 20.3 0.1 0.033 14.2 0.1 3.2 2 1 1 3 3 3 1 non-SMC mitotic condensation complex subunit 1 T3SS_basalb_I PF17001.5 CCF33459.1 - 0.0046 17.5 0.1 0.022 15.4 0.1 2.2 1 0 0 1 1 1 1 Type III secretion basal body protein I, YscI, HrpB, PscI DUF1090 PF06476.12 CCF33459.1 - 0.012 15.8 0.8 0.049 13.7 0.8 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1090) DUF1664 PF07889.12 CCF33459.1 - 0.1 12.7 0.2 23 5.0 0.0 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) PMR5N PF14416.6 CCF33460.1 - 4.5 7.7 8.2 29 5.1 4.6 3.1 2 1 0 2 2 2 0 PMR5 N terminal Domain Cu_amine_oxid PF01179.20 CCF33464.1 - 1.1e-55 189.2 0.0 1.4e-55 188.8 0.0 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN2 PF02727.16 CCF33464.1 - 7.1e-05 23.0 0.0 0.00015 22.0 0.0 1.5 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain Gly_transf_sug PF04488.15 CCF33465.1 - 2.2e-14 53.9 0.0 3.9e-14 53.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif SH3_1 PF00018.28 CCF33466.1 - 5.8e-27 93.0 0.0 3e-13 49.2 0.0 2.7 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.6 CCF33466.1 - 1.9e-18 66.1 0.1 3.3e-09 36.4 0.1 2.8 2 0 0 2 2 2 2 Variant SH3 domain PX PF00787.24 CCF33466.1 - 8.4e-13 48.3 0.0 1.7e-12 47.3 0.0 1.5 1 0 0 1 1 1 1 PX domain SH3_2 PF07653.17 CCF33466.1 - 1.7e-12 46.8 0.0 1.5e-07 31.0 0.0 2.6 2 0 0 2 2 2 2 Variant SH3 domain PB1 PF00564.24 CCF33466.1 - 5.1e-08 32.7 0.1 8.3e-08 32.1 0.1 1.3 1 0 0 1 1 1 1 PB1 domain Rad60-SLD PF11976.8 CCF33466.1 - 0.11 12.3 0.4 0.69 9.8 0.3 2.3 1 1 1 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like Spt20 PF12090.8 CCF33466.1 - 3.1 7.4 12.7 6.3 6.3 12.7 1.5 1 0 0 1 1 1 0 Spt20 family Hydin_ADK PF17213.3 CCF33466.1 - 5 7.3 7.6 0.69 10.2 3.5 1.6 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain ADH_zinc_N PF00107.26 CCF33467.1 - 2.4e-21 76.0 0.2 3.6e-21 75.5 0.2 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCF33467.1 - 7.8e-14 52.9 0.9 1e-13 52.5 0.2 1.5 2 0 0 2 2 2 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 CCF33467.1 - 0.0019 17.5 0.2 0.0027 17.0 0.2 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_7 PF13241.6 CCF33467.1 - 0.069 13.6 0.1 0.15 12.5 0.1 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding Glyco_hydro_3 PF00933.21 CCF33471.1 - 9.4e-45 153.3 0.0 1.3e-44 152.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Acetyltransf_1 PF00583.25 CCF33471.1 - 0.00045 20.4 0.0 0.0018 18.5 0.0 2.0 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Glyco_hydro_3_C PF01915.22 CCF33471.1 - 0.0075 16.2 0.0 0.015 15.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_31 PF01055.26 CCF33472.1 - 5.6e-108 362.0 0.4 6.8e-108 361.7 0.4 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 CCF33472.1 - 1.4e-13 50.9 0.3 7.2e-13 48.7 0.1 2.3 3 0 0 3 3 3 1 Galactose mutarotase-like adh_short PF00106.25 CCF33473.1 - 0.00089 18.8 0.0 0.27 10.7 0.0 2.8 3 0 0 3 3 3 2 short chain dehydrogenase DUF3984 PF13136.6 CCF33473.1 - 0.023 14.1 0.4 0.037 13.4 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3984) FAD_binding_4 PF01565.23 CCF33474.1 - 3.2e-24 85.2 4.5 6.7e-24 84.2 4.5 1.6 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 CCF33474.1 - 6e-09 35.9 0.4 1.1e-08 35.1 0.4 1.4 1 0 0 1 1 1 1 Berberine and berberine like UbiA PF01040.18 CCF33476.1 - 8.3e-23 81.0 7.0 1.4e-22 80.2 6.9 1.4 1 1 0 1 1 1 1 UbiA prenyltransferase family zf-piccolo PF05715.13 CCF33477.1 - 2.2 8.5 10.0 0.34 11.1 3.4 2.5 2 0 0 2 2 2 0 Piccolo Zn-finger MRP-L20 PF12824.7 CCF33478.1 - 7e-49 166.1 1.2 8.2e-49 165.9 1.2 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 Neugrin PF06413.11 CCF33478.1 - 6.3e-05 23.1 0.0 0.00011 22.4 0.0 1.3 1 0 0 1 1 1 1 Neugrin HEV_ORF1 PF02444.16 CCF33478.1 - 0.43 11.2 5.2 0.45 11.1 3.5 1.7 2 0 0 2 2 2 0 Hepatitis E virus ORF-2 (Putative capsid protein) KxDL PF10241.9 CCF33479.1 - 1.9e-30 105.0 2.3 2.7e-30 104.5 2.3 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein DUF2385 PF09539.10 CCF33479.1 - 0.0062 17.0 0.8 0.014 15.9 0.8 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2385) XylR_N PF06505.11 CCF33479.1 - 0.34 10.7 1.0 0.47 10.2 0.1 1.6 2 0 0 2 2 2 0 Activator of aromatic catabolism DUF883 PF05957.13 CCF33479.1 - 0.77 10.4 5.7 5.6 7.6 1.6 2.2 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) ATP-synt_F PF01990.17 CCF33481.1 - 4.3e-34 116.7 0.1 5e-34 116.5 0.1 1.0 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit DXP_synthase_N PF13292.6 CCF33481.1 - 0.033 13.4 0.0 0.033 13.4 0.0 1.1 1 0 0 1 1 1 0 1-deoxy-D-xylulose-5-phosphate synthase E1_DerP2_DerF2 PF02221.15 CCF33482.1 - 1.7e-27 96.5 0.4 2e-27 96.2 0.4 1.1 1 0 0 1 1 1 1 ML domain Cpn10 PF00166.21 CCF33483.1 - 8.5e-29 99.5 0.0 9.5e-29 99.3 0.0 1.0 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit 5-FTHF_cyc-lig PF01812.20 CCF33483.1 - 0.093 12.6 0.0 0.11 12.4 0.0 1.1 1 0 0 1 1 1 0 5-formyltetrahydrofolate cyclo-ligase family Pkinase PF00069.25 CCF33484.1 - 1.8e-46 158.6 0.0 4.8e-46 157.3 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF33484.1 - 2.5e-20 72.9 0.0 4.5e-20 72.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CCF33484.1 - 0.024 14.6 0.0 0.046 13.6 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 CCF33484.1 - 0.2 10.6 0.0 0.3 10.0 0.0 1.1 1 0 0 1 1 1 0 Haspin like kinase domain Ribosomal_L11 PF00298.19 CCF33485.1 - 6e-29 100.3 0.0 1.1e-28 99.5 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Ribosomal_L11_N PF03946.14 CCF33485.1 - 2.3e-25 88.2 0.1 3.7e-25 87.5 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Microvir_J PF04726.13 CCF33485.1 - 0.55 10.3 3.1 2.7 8.0 0.3 2.5 2 0 0 2 2 2 0 Microvirus J protein Svf1_C PF17187.4 CCF33486.1 - 3.9e-61 205.7 0.0 3.3e-60 202.7 0.0 2.1 2 0 0 2 2 2 1 Svf1-like C-terminal lipocalin-like domain Svf1 PF08622.10 CCF33486.1 - 4.4e-55 186.2 0.0 6.4e-55 185.7 0.0 1.3 1 0 0 1 1 1 1 Svf1-like N-terminal lipocalin domain CENP-T_C PF15511.6 CCF33487.1 - 5.6e-05 23.2 0.0 9.3e-05 22.5 0.0 1.3 1 1 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Histone PF00125.24 CCF33487.1 - 0.0023 18.3 0.0 0.0031 17.9 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 PCP_red PF08369.10 CCF33487.1 - 0.031 14.5 0.4 0.48 10.7 0.1 2.3 2 0 0 2 2 2 0 Proto-chlorophyllide reductase 57 kD subunit CBFD_NFYB_HMF PF00808.23 CCF33487.1 - 0.068 13.5 0.0 0.11 12.7 0.0 1.4 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Acetyltransf_1 PF00583.25 CCF33488.1 - 0.0013 18.9 0.0 0.0023 18.1 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Mis12 PF05859.12 CCF33490.1 - 4.7e-43 146.5 0.0 8.7e-43 145.6 0.0 1.4 1 0 0 1 1 1 1 Mis12 protein Peptidase_M14 PF00246.24 CCF33491.1 - 2.5e-69 234.3 0.0 3e-69 234.0 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.16 CCF33491.1 - 0.074 13.5 0.0 0.2 12.1 0.0 1.7 1 0 0 1 1 1 0 Carboxypeptidase activation peptide PPR_2 PF13041.6 CCF33492.1 - 2.8e-26 91.4 0.0 1.2e-11 44.6 0.0 5.8 4 1 1 5 5 5 5 PPR repeat family PPR_3 PF13812.6 CCF33492.1 - 3.8e-18 65.3 0.0 1.2e-07 31.6 0.0 4.4 4 0 0 4 4 4 3 Pentatricopeptide repeat domain PPR_long PF17177.4 CCF33492.1 - 2e-14 53.4 0.1 7.2e-08 32.1 0.1 3.3 2 1 0 3 3 3 3 Pentacotripeptide-repeat region of PRORP PPR PF01535.20 CCF33492.1 - 2.9e-10 39.7 0.2 0.065 13.5 0.1 6.3 7 0 0 7 7 7 3 PPR repeat PPR_1 PF12854.7 CCF33492.1 - 1.8e-08 33.9 0.0 0.0094 15.6 0.0 5.0 4 0 0 4 4 4 1 PPR repeat Exog_C PF18026.1 CCF33492.1 - 0.0018 18.3 0.0 9.2 6.4 0.0 4.2 4 1 1 5 5 5 1 Endo/exonuclease (EXOG) C-terminal domain DUF1150 PF06620.11 CCF33492.1 - 0.0072 16.4 0.0 0.025 14.7 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1150) MRP-S27 PF10037.9 CCF33492.1 - 0.064 12.1 0.0 2.5 6.9 0.0 2.7 3 0 0 3 3 3 0 Mitochondrial 28S ribosomal protein S27 Amidohydro_3 PF07969.11 CCF33493.1 - 1.2e-06 28.3 0.2 1.8e-06 27.7 0.2 1.3 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_1 PF01979.20 CCF33493.1 - 3e-06 26.8 0.3 4e-06 26.4 0.3 1.2 1 0 0 1 1 1 1 Amidohydrolase family Urease_alpha PF00449.20 CCF33493.1 - 0.0085 16.4 1.2 0.045 14.1 0.5 2.0 1 1 0 2 2 2 1 Urease alpha-subunit, N-terminal domain CN_hydrolase PF00795.22 CCF33494.1 - 3.3e-45 154.5 0.0 5.1e-45 153.8 0.0 1.3 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Asp_Glu_race PF01177.22 CCF33494.1 - 3.9e-10 39.9 0.0 7.1e-10 39.1 0.0 1.4 1 0 0 1 1 1 1 Asp/Glu/Hydantoin racemase Amdase PF17645.1 CCF33494.1 - 0.031 13.9 0.7 0.063 12.9 0.4 1.8 1 1 1 2 2 2 0 Arylmalonate decarboxylase Fungal_trans PF04082.18 CCF33495.1 - 9.1e-19 67.5 0.9 1.5e-18 66.8 0.9 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF33495.1 - 0.0059 16.7 10.0 0.011 15.8 10.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PDE8 PF08629.10 CCF33495.1 - 0.059 13.4 0.2 0.15 12.0 0.2 1.6 1 0 0 1 1 1 0 PDE8 phosphodiesterase GPR_Gpa2_C PF11970.8 CCF33495.1 - 0.12 12.4 0.0 0.29 11.2 0.0 1.6 1 0 0 1 1 1 0 G protein-coupled glucose receptor regulating Gpa2 C-term NAD_binding_4 PF07993.12 CCF33496.1 - 8.1e-40 136.6 0.0 1.1e-39 136.2 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein PP-binding PF00550.25 CCF33496.1 - 2.4e-11 43.8 0.0 5.8e-11 42.6 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site Epimerase PF01370.21 CCF33496.1 - 4.5e-10 39.4 0.0 7.2e-10 38.7 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 CCF33496.1 - 0.00027 20.9 0.5 0.0027 17.6 0.2 2.6 2 2 0 2 2 2 1 KR domain 3Beta_HSD PF01073.19 CCF33496.1 - 0.0027 16.7 0.0 0.0049 15.9 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 CCF33496.1 - 0.0078 15.6 0.0 0.013 14.9 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase CYSTM PF12734.7 CCF33500.1 - 4.9e-12 46.0 22.0 4.9e-12 46.0 22.0 4.9 2 1 2 4 4 4 1 Cysteine-rich TM module stress tolerance Pex14_N PF04695.13 CCF33500.1 - 0.17 12.6 3.4 0.24 12.1 3.4 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Arrestin_N PF00339.29 CCF33501.1 - 4.5e-20 72.2 0.0 3.5e-19 69.3 0.0 2.3 3 0 0 3 3 3 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 CCF33501.1 - 2.5e-06 28.0 0.0 0.00011 22.7 0.0 2.4 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain ketoacyl-synt PF00109.26 CCF33502.1 - 3.1e-65 220.3 0.0 8e-65 218.9 0.0 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain PS-DH PF14765.6 CCF33502.1 - 6e-50 170.2 0.0 9.2e-50 169.5 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 CCF33502.1 - 4.8e-39 134.7 0.3 2.1e-38 132.6 0.3 2.0 1 1 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 CCF33502.1 - 5.5e-30 103.8 0.0 1.7e-29 102.2 0.0 1.9 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 CCF33502.1 - 3.1e-17 63.1 0.0 8.5e-17 61.6 0.0 1.8 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Thiolase_N PF00108.23 CCF33502.1 - 9.6e-05 21.9 0.2 0.0002 20.9 0.2 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain SAT PF16073.5 CCF33502.1 - 0.016 15.0 0.4 0.039 13.7 0.4 1.7 1 0 0 1 1 1 0 Starter unit:ACP transacylase in aflatoxin biosynthesis Gcn1_N PF12074.8 CCF33503.1 - 1.3e-130 435.8 5.5 3.7e-130 434.4 5.5 1.8 1 0 0 1 1 1 1 Generalcontrol nonderepressible 1 (Gcn1) N-terminal HEAT_EZ PF13513.6 CCF33503.1 - 1.1e-18 67.3 23.2 1.7e-06 28.4 0.0 13.0 12 2 4 16 16 14 3 HEAT-like repeat HEAT PF02985.22 CCF33503.1 - 1.6e-16 59.0 19.7 0.075 13.3 0.0 13.8 17 0 0 17 17 17 5 HEAT repeat HEAT_2 PF13646.6 CCF33503.1 - 1.6e-15 57.2 20.0 1.1e-05 25.7 0.0 10.2 8 2 4 12 12 12 4 HEAT repeats Vac14_Fab1_bd PF12755.7 CCF33503.1 - 4.2e-07 30.5 0.0 0.35 11.5 0.0 5.5 4 1 1 5 5 5 1 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 CCF33503.1 - 1.1e-05 25.6 0.0 0.59 10.2 0.0 5.2 4 1 1 5 5 5 1 non-SMC mitotic condensation complex subunit 1 TIP120 PF08623.10 CCF33503.1 - 2.5e-05 24.1 0.0 0.015 15.1 0.0 4.1 2 1 0 2 2 2 1 TATA-binding protein interacting (TIP20) Ecm29 PF13001.7 CCF33503.1 - 0.0012 17.6 0.0 3.1 6.3 0.0 3.6 2 1 1 3 3 3 2 Proteasome stabiliser Tti2 PF10521.9 CCF33503.1 - 0.004 16.7 0.5 9.3 5.7 0.0 4.5 4 1 1 5 5 5 1 Tti2 family CLASP_N PF12348.8 CCF33503.1 - 0.0051 16.4 0.0 3.9 7.0 0.0 4.0 1 1 1 3 3 3 1 CLASP N terminal RPAP3_C PF13877.6 CCF33503.1 - 0.062 13.8 0.0 0.54 10.8 0.0 2.7 2 0 0 2 2 2 0 Potential Monad-binding region of RPAP3 DLIC PF05783.11 CCF33504.1 - 0.038 12.8 2.7 0.039 12.8 2.7 1.0 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) Cpn60_TCP1 PF00118.24 CCF33505.1 - 1.5e-25 89.8 0.0 2.3e-25 89.2 0.0 1.2 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family SusD-like PF12741.7 CCF33505.1 - 0.041 12.8 0.2 0.067 12.1 0.2 1.2 1 0 0 1 1 1 0 Susd and RagB outer membrane lipoprotein CUE PF02845.16 CCF33506.1 - 1.7e-07 30.8 0.0 2.8e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 CUE domain DUF3697 PF12478.8 CCF33506.1 - 0.089 12.9 2.8 0.59 10.3 0.0 2.8 2 0 0 2 2 2 0 Ubiquitin-associated protein 2 PAP2_3 PF14378.6 CCF33509.1 - 8.4e-25 87.6 11.6 5e-18 65.5 3.9 2.6 2 0 0 2 2 2 2 PAP2 superfamily RtcB PF01139.17 CCF33509.1 - 0.0077 15.5 0.0 0.011 14.9 0.0 1.1 1 0 0 1 1 1 1 tRNA-splicing ligase RtcB ThrE PF06738.12 CCF33509.1 - 0.05 13.0 0.0 0.092 12.1 0.0 1.4 1 0 0 1 1 1 0 Putative threonine/serine exporter Inositol_P PF00459.25 CCF33511.1 - 2.9e-34 118.8 0.0 1.3e-33 116.6 0.0 1.9 1 1 0 1 1 1 1 Inositol monophosphatase family DUF3899 PF13038.6 CCF33512.1 - 0.73 10.4 7.6 0.57 10.7 0.2 3.8 4 1 1 5 5 5 0 Domain of unknown function (DUF3899) MFS_1 PF07690.16 CCF33512.1 - 1.4 7.8 15.1 1.3 7.8 4.2 2.7 2 1 1 3 3 3 0 Major Facilitator Superfamily Glyco_hydro_88 PF07470.13 CCF33513.1 - 2.6e-64 217.5 4.4 3.1e-64 217.2 4.4 1.0 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 Glyco_hydro_127 PF07944.12 CCF33513.1 - 0.0037 15.8 0.0 0.0069 14.9 0.0 1.4 2 0 0 2 2 2 1 Beta-L-arabinofuranosidase, GH127 C5-epim_C PF06662.13 CCF33513.1 - 0.0059 16.1 0.3 0.15 11.6 0.1 2.5 1 1 1 2 2 2 1 D-glucuronyl C5-epimerase C-terminus Arylsulfotran_2 PF14269.6 CCF33515.1 - 0.083 12.2 0.0 0.1 11.9 0.0 1.1 1 0 0 1 1 1 0 Arylsulfotransferase (ASST) N2227 PF07942.12 CCF33516.1 - 1.8e-61 207.7 0.0 2.8e-61 207.1 0.0 1.3 1 0 0 1 1 1 1 N2227-like protein Methyltransf_12 PF08242.12 CCF33516.1 - 1.8e-05 25.4 0.4 0.00013 22.6 0.0 2.5 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF33516.1 - 7.5e-05 23.3 0.1 0.00036 21.1 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF33516.1 - 0.00034 20.5 0.0 0.00082 19.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF33516.1 - 0.011 15.6 0.0 0.14 12.0 0.0 2.5 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_25 PF13649.6 CCF33516.1 - 0.015 16.0 0.2 0.06 14.1 0.0 2.2 3 0 0 3 3 3 0 Methyltransferase domain GAT PF03127.14 CCF33516.1 - 0.041 14.2 0.0 0.086 13.2 0.0 1.4 1 0 0 1 1 1 0 GAT domain YppG PF14179.6 CCF33516.1 - 0.12 13.1 0.0 2.8 8.7 0.0 2.5 3 0 0 3 3 3 0 YppG-like protein DUF1153 PF06627.11 CCF33516.1 - 0.12 12.5 0.0 0.3 11.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1153) Cellulase PF00150.18 CCF33517.1 - 2.2e-30 106.0 0.0 3.3e-30 105.5 0.0 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Kazal_1 PF00050.21 CCF33518.1 - 0.019 15.0 3.1 0.043 13.8 3.1 1.5 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.15 CCF33518.1 - 0.021 14.9 2.7 0.039 14.1 2.7 1.4 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain Sugar_tr PF00083.24 CCF33519.1 - 7.5e-75 252.5 20.4 9e-75 252.3 20.4 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF33519.1 - 5.4e-20 71.6 45.7 3.9e-15 55.6 29.0 2.3 1 1 2 3 3 3 2 Major Facilitator Superfamily NapD PF03927.13 CCF33519.1 - 0.091 12.8 0.0 0.2 11.7 0.0 1.5 1 0 0 1 1 1 0 NapD protein p450 PF00067.22 CCF33520.1 - 1.4e-56 192.1 0.0 1.7e-56 191.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Clr5 PF14420.6 CCF33521.1 - 2.5e-16 59.6 0.9 1.3e-15 57.4 0.1 2.6 3 0 0 3 3 3 1 Clr5 domain Tetraspanin PF00335.20 CCF33522.1 - 2.7e-05 24.0 0.0 5.5e-05 23.0 0.0 1.6 1 1 0 1 1 1 1 Tetraspanin family PI-PLC-X PF00388.19 CCF33523.1 - 3.9e-49 166.0 0.0 5.9e-49 165.4 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 CCF33523.1 - 1.1e-31 109.6 0.0 1.8e-31 108.9 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain DUF4208 PF13907.6 CCF33524.1 - 0.11 13.0 0.4 0.22 12.0 0.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4208) Ribosomal_L36e PF01158.18 CCF33524.1 - 0.95 9.7 5.6 0.12 12.6 1.1 1.8 2 0 0 2 2 2 0 Ribosomal protein L36e DEAD PF00270.29 CCF33525.1 - 2e-44 151.4 0.2 3.1e-44 150.8 0.2 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF33525.1 - 5.4e-18 65.4 0.0 1.7e-17 63.8 0.0 1.9 1 1 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 CCF33525.1 - 1.3e-15 57.4 0.1 2.9e-15 56.2 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 CCF33525.1 - 6.6e-07 29.5 0.0 2.2e-06 27.8 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Ank_2 PF12796.7 CCF33526.1 - 6.5e-56 186.9 2.3 5e-14 52.6 0.0 5.9 2 1 4 6 6 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CCF33526.1 - 2e-41 139.8 1.7 2.6e-10 40.6 0.0 7.9 2 2 6 8 8 8 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCF33526.1 - 7.9e-38 124.2 2.1 0.0011 19.2 0.0 9.8 9 0 0 9 9 9 8 Ankyrin repeat Ank PF00023.30 CCF33526.1 - 4.7e-36 121.7 11.4 1.8e-05 25.0 0.0 9.6 9 0 0 9 9 9 7 Ankyrin repeat Ank_5 PF13857.6 CCF33526.1 - 2e-35 120.4 2.5 1.1e-08 35.2 0.0 7.5 2 2 6 8 8 8 7 Ankyrin repeats (many copies) NACHT PF05729.12 CCF33526.1 - 1.4e-17 64.1 0.1 3e-17 63.0 0.1 1.6 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 CCF33526.1 - 9.6e-06 26.1 0.1 0.00015 22.2 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain PNP_UDP_1 PF01048.20 CCF33526.1 - 8.8e-05 21.9 0.0 0.051 12.8 0.0 2.3 2 0 0 2 2 2 2 Phosphorylase superfamily NB-ARC PF00931.22 CCF33526.1 - 0.0026 17.0 0.6 0.0091 15.2 0.0 2.1 2 0 0 2 2 2 1 NB-ARC domain AAA PF00004.29 CCF33526.1 - 0.0031 18.0 0.0 0.0088 16.5 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CCF33526.1 - 0.006 16.9 0.0 0.016 15.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain Nse4-Nse3_bdg PF15412.6 CCF33526.1 - 0.0092 16.1 0.2 59 3.9 0.0 4.2 5 0 0 5 5 4 0 Binding domain of Nse4/EID3 to Nse3-MAGE DUF4795 PF16043.5 CCF33526.1 - 0.015 14.9 0.4 0.59 9.7 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) AAA_14 PF13173.6 CCF33526.1 - 0.02 14.9 0.0 0.055 13.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain RVP PF00077.20 CCF33526.1 - 0.02 15.2 2.5 22 5.5 0.0 4.2 2 1 2 4 4 3 0 Retroviral aspartyl protease RNA_helicase PF00910.22 CCF33526.1 - 0.03 14.7 0.0 0.083 13.3 0.0 1.8 1 0 0 1 1 1 0 RNA helicase ATPase PF06745.13 CCF33526.1 - 0.037 13.4 0.0 0.085 12.2 0.0 1.5 1 0 0 1 1 1 0 KaiC Viral_helicase1 PF01443.18 CCF33526.1 - 0.088 12.5 0.0 0.19 11.5 0.0 1.5 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase ATPase_2 PF01637.18 CCF33526.1 - 0.15 12.0 0.0 0.34 10.8 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Utp12 PF04003.12 CCF33526.1 - 0.17 12.2 2.0 2.9 8.2 0.5 3.2 2 1 0 2 2 2 0 Dip2/Utp12 Family VWA_3_C PF18571.1 CCF33526.1 - 1.5 8.8 3.8 68 3.4 0.0 4.3 5 0 0 5 5 4 0 von Willebrand factor type A C-terminal domain BCS1_N PF08740.11 CCF33527.1 - 1.8e-33 116.1 0.1 2.5e-33 115.7 0.1 1.1 1 0 0 1 1 1 1 BCS1 N terminal MIF4G PF02854.19 CCF33528.1 - 4.6e-58 196.3 0.0 8e-32 110.6 0.0 3.5 3 1 0 3 3 3 2 MIF4G domain Upf2 PF04050.14 CCF33528.1 - 1.1e-41 142.8 7.3 1.1e-41 142.8 7.3 2.4 2 0 0 2 2 2 1 Up-frameshift suppressor 2 CBP4 PF07960.11 CCF33528.1 - 0.087 12.7 0.0 0.087 12.7 0.0 2.3 3 0 0 3 3 3 0 CBP4 DUF349 PF03993.12 CCF33528.1 - 0.17 12.2 5.2 6.4 7.2 5.2 3.1 1 1 0 1 1 1 0 Domain of Unknown Function (DUF349) CDC45 PF02724.14 CCF33528.1 - 1.2 7.3 7.6 2.1 6.5 7.6 1.4 1 0 0 1 1 1 0 CDC45-like protein Pkinase_Tyr PF07714.17 CCF33529.1 - 0.024 13.9 0.0 0.04 13.2 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase Ribonuc_L-PSP PF01042.21 CCF33531.1 - 8.5e-19 67.7 0.0 1.1e-18 67.4 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP DUF1145 PF06611.12 CCF33532.1 - 0.01 15.8 0.2 0.032 14.2 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1145) Acp26Ab PF05777.12 CCF33532.1 - 0.066 13.8 0.0 0.091 13.4 0.0 1.1 1 0 0 1 1 1 0 Drosophila accessory gland-specific peptide 26Ab (Acp26Ab) DUF1269 PF06897.12 CCF33532.1 - 0.16 12.3 0.6 0.26 11.6 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1269) zf-C2H2 PF00096.26 CCF33533.1 - 1.4e-09 37.9 11.3 0.00016 21.9 5.7 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CCF33533.1 - 6.4e-07 29.5 17.5 2.4e-05 24.5 3.5 3.5 3 1 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 CCF33533.1 - 4.8e-06 26.9 10.4 0.011 16.5 4.2 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-UBR PF02207.20 CCF33533.1 - 0.0036 17.4 1.3 0.0054 16.9 1.3 1.3 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) zf-C2H2_jaz PF12171.8 CCF33533.1 - 0.008 16.4 0.4 0.008 16.4 0.4 2.2 2 1 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.5 CCF33533.1 - 0.039 13.7 0.2 0.039 13.7 0.2 2.3 2 0 0 2 2 2 0 zinc-finger C2H2-type GAGA PF09237.11 CCF33533.1 - 0.33 10.8 4.9 10 6.0 0.2 2.2 1 1 1 2 2 2 0 GAGA factor zf-C2H2_6 PF13912.6 CCF33533.1 - 1.5 8.9 12.0 0.57 10.3 4.2 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger Cupin_1 PF00190.22 CCF33538.1 - 6.5e-36 123.2 0.2 3.1e-17 62.6 0.1 2.1 2 0 0 2 2 2 2 Cupin Cupin_2 PF07883.11 CCF33538.1 - 7.4e-23 80.1 0.1 3.7e-12 45.8 0.2 2.5 2 0 0 2 2 2 2 Cupin domain Cupin_3 PF05899.12 CCF33538.1 - 3.5e-08 33.0 0.1 0.0062 16.2 0.1 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF861) AraC_binding PF02311.19 CCF33538.1 - 3.7e-07 30.1 0.0 0.00041 20.3 0.0 2.5 2 0 0 2 2 2 2 AraC-like ligand binding domain MannoseP_isomer PF01050.18 CCF33538.1 - 2.6e-05 24.1 0.0 0.0057 16.6 0.0 2.2 2 0 0 2 2 2 2 Mannose-6-phosphate isomerase Cupin_6 PF12852.7 CCF33538.1 - 0.0012 18.6 0.0 0.025 14.3 0.0 2.2 1 1 0 2 2 2 1 Cupin 3-HAO PF06052.12 CCF33538.1 - 0.0021 17.7 0.0 0.013 15.1 0.0 2.0 2 0 0 2 2 2 1 3-hydroxyanthranilic acid dioxygenase ARD PF03079.14 CCF33538.1 - 0.2 11.9 0.0 0.96 9.6 0.0 1.9 2 0 0 2 2 2 0 ARD/ARD' family MS_channel PF00924.18 CCF33540.1 - 7.8e-19 68.0 2.4 1.3e-18 67.3 2.4 1.3 1 0 0 1 1 1 1 Mechanosensitive ion channel EF-hand_5 PF13202.6 CCF33540.1 - 0.17 11.4 0.2 0.44 10.1 0.2 1.7 1 0 0 1 1 1 0 EF hand DLH PF01738.18 CCF33541.1 - 2.7e-23 82.7 0.0 5.7e-23 81.6 0.0 1.5 1 1 0 1 1 1 1 Dienelactone hydrolase family BAAT_C PF08840.11 CCF33541.1 - 0.081 12.8 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Peptidase_S15 PF02129.18 CCF33541.1 - 0.17 11.4 0.0 0.26 10.8 0.0 1.2 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Glyco_hydro_12 PF01670.16 CCF33542.1 - 1.4e-23 84.1 0.4 1.5e-23 83.9 0.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 12 Aldose_epim PF01263.20 CCF33542.1 - 0.074 12.3 0.0 0.08 12.2 0.0 1.1 1 0 0 1 1 1 0 Aldose 1-epimerase HTH_52 PF18576.1 CCF33542.1 - 0.093 12.9 0.0 0.12 12.6 0.0 1.2 1 0 0 1 1 1 0 Helix-turn-helix domain LRR_4 PF12799.7 CCF33543.1 - 0.0025 18.2 5.9 1.1 9.8 0.0 5.4 6 0 0 6 6 6 1 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 CCF33543.1 - 0.054 13.6 7.3 0.59 10.3 0.0 4.3 4 0 0 4 4 4 0 Leucine Rich repeat LRR_8 PF13855.6 CCF33543.1 - 0.13 12.1 1.1 16 5.4 0.0 4.4 5 1 0 5 5 5 0 Leucine rich repeat Peptidase_S9 PF00326.21 CCF33544.1 - 9.9e-55 185.3 0.0 1.6e-54 184.6 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family PD40 PF07676.12 CCF33544.1 - 0.0075 16.2 0.0 1 9.4 0.0 2.7 2 0 0 2 2 2 2 WD40-like Beta Propeller Repeat NuA4 PF09340.10 CCF33545.1 - 1.1e-24 86.1 0.1 1.1e-24 86.1 0.1 1.9 2 0 0 2 2 2 1 Histone acetyltransferase subunit NuA4 DUF4407 PF14362.6 CCF33545.1 - 0.072 12.4 4.5 0.089 12.1 4.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) PAS_3 PF08447.12 CCF33547.1 - 2.7e-16 59.6 0.0 3.5e-12 46.5 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.7 CCF33547.1 - 1.3e-09 38.2 0.0 1.2e-06 28.7 0.0 2.5 2 0 0 2 2 2 2 PAS domain PAS PF00989.25 CCF33547.1 - 1.1e-07 31.8 0.0 0.00018 21.5 0.0 2.7 2 0 0 2 2 2 2 PAS fold PAS_11 PF14598.6 CCF33547.1 - 1.1e-05 25.6 0.0 4.2e-05 23.6 0.0 2.0 2 0 0 2 2 2 1 PAS domain PAS_4 PF08448.10 CCF33547.1 - 0.00079 19.7 0.0 0.13 12.5 0.0 2.9 2 0 0 2 2 2 1 PAS fold Med13_C PF06333.12 CCF33547.1 - 0.53 9.5 0.0 0.53 9.5 0.0 3.1 3 0 0 3 3 3 0 Mediator complex subunit 13 C-terminal domain Yip1 PF04893.17 CCF33548.1 - 2.3e-11 43.7 18.0 3.3e-11 43.2 17.8 1.5 1 1 0 1 1 1 1 Yip1 domain Ran_BP1 PF00638.18 CCF33549.1 - 3.7e-12 46.6 1.2 3.3e-05 24.1 0.0 2.8 3 0 0 3 3 3 2 RanBP1 domain DEAD PF00270.29 CCF33550.1 - 3.6e-29 101.8 0.0 8.8e-29 100.5 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF1998 PF09369.10 CCF33550.1 - 1.4e-20 73.8 0.2 4.1e-20 72.3 0.2 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1998) Helicase_C PF00271.31 CCF33550.1 - 6e-12 45.9 0.0 5e-11 42.9 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCF33550.1 - 1.4e-07 31.7 0.0 2.5e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CDT1 PF08839.11 CCF33550.1 - 9.3e-06 26.1 0.0 2.4e-05 24.7 0.0 1.7 1 0 0 1 1 1 1 DNA replication factor CDT1 like Na_Ca_ex PF01699.24 CCF33551.1 - 2.5e-23 82.7 28.5 3.6e-12 46.5 6.9 2.2 2 0 0 2 2 2 2 Sodium/calcium exchanger protein DUF4536 PF15055.6 CCF33551.1 - 0.085 13.1 0.2 0.26 11.5 0.2 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4536) Otopetrin PF03189.13 CCF33551.1 - 0.11 11.3 3.9 0.2 10.5 3.6 1.5 1 1 0 1 1 1 0 Otopetrin Oxidored_q4 PF00507.19 CCF33551.1 - 0.53 10.5 3.6 0.59 10.3 0.3 2.6 2 0 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 DEAD PF00270.29 CCF33553.1 - 5.6e-43 146.7 0.0 8.4e-43 146.2 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF33553.1 - 7.5e-28 97.1 0.6 7.2e-27 93.9 0.3 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain CMS1 PF14617.6 CCF33553.1 - 0.091 12.1 0.0 0.19 11.0 0.0 1.5 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit GatB_Yqey PF02637.18 CCF33555.1 - 4e-11 43.0 0.0 5.6e-11 42.5 0.0 1.2 1 0 0 1 1 1 1 GatB domain RabGAP-TBC PF00566.18 CCF33556.1 - 4.6e-37 127.8 6.4 1.8e-36 125.8 6.4 2.0 1 1 0 1 1 1 1 Rab-GTPase-TBC domain Sugar_tr PF00083.24 CCF33558.1 - 2.2e-117 392.7 24.9 2.6e-117 392.5 24.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF33558.1 - 1.9e-19 69.8 25.1 1.9e-19 69.8 25.1 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 CCF33558.1 - 0.00026 19.5 0.3 0.00026 19.5 0.3 1.5 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) zf-RNPHF PF08080.12 CCF33558.1 - 0.03 14.3 0.2 2.1 8.4 0.0 3.0 2 0 0 2 2 2 0 RNPHF zinc finger Peptidase_M3 PF01432.20 CCF33559.1 - 6.6e-124 414.6 0.0 8.5e-124 414.3 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M3 Mersacidin PF16934.5 CCF33560.1 - 0.05 13.4 0.1 0.054 13.3 0.1 1.2 1 0 0 1 1 1 0 Two-component Enterococcus faecalis cytolysin (EFC) Glyco_hydro_61 PF03443.14 CCF33561.1 - 1.3e-53 182.0 0.0 2.1e-53 181.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 MAGE_N PF12440.8 CCF33561.1 - 1.1 9.9 9.1 0.074 13.7 2.6 2.1 1 1 1 2 2 2 0 Melanoma associated antigen family N terminal p450 PF00067.22 CCF33564.1 - 1.4e-42 146.0 0.0 4.3e-28 98.3 0.0 2.7 2 1 0 2 2 2 2 Cytochrome P450 Peptidase_S10 PF00450.22 CCF33565.1 - 8.6e-51 173.6 4.0 9.7e-51 173.5 4.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase DUF1057 PF06342.12 CCF33565.1 - 0.082 11.9 1.9 0.06 12.4 0.3 1.6 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF1057) Kinesin PF00225.23 CCF33569.1 - 1.2e-94 317.0 0.0 2.1e-94 316.2 0.0 1.4 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 CCF33569.1 - 3.7e-21 75.6 0.0 1.2e-20 74.0 0.0 1.8 2 0 0 2 2 2 1 Microtubule binding PKcGMP_CC PF16808.5 CCF33569.1 - 0.0073 16.1 0.4 0.0073 16.1 0.4 4.0 4 0 0 4 4 4 1 Coiled-coil N-terminus of cGMP-dependent protein kinase ALC PF17527.2 CCF33569.1 - 0.012 15.3 0.4 0.031 13.9 0.4 1.7 1 0 0 1 1 1 0 Phage ALC protein Tho2 PF11262.8 CCF33569.1 - 0.66 9.1 2.7 1.2 8.3 2.7 1.4 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 FapA PF03961.13 CCF33569.1 - 5 5.6 6.7 3.8 6.0 3.4 2.3 3 0 0 3 3 3 0 Flagellar Assembly Protein A Melibiase PF02065.18 CCF33570.1 - 8.7e-146 485.3 0.0 1.1e-145 485.0 0.0 1.1 1 0 0 1 1 1 1 Melibiase Glyco_hydro_36N PF16875.5 CCF33570.1 - 6.6e-81 271.6 0.0 9.6e-81 271.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 36 N-terminal domain Glyco_hydro_36C PF16874.5 CCF33570.1 - 1.8e-23 82.8 0.1 3.4e-23 81.9 0.1 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 36 C-terminal domain GHL10 PF02638.15 CCF33570.1 - 0.00028 20.1 0.0 0.00044 19.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase-like 10 AA_permease_2 PF13520.6 CCF33572.1 - 3.8e-64 217.1 45.9 4.8e-64 216.8 45.9 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CCF33572.1 - 4.1e-14 52.1 41.3 5.4e-14 51.6 41.3 1.1 1 0 0 1 1 1 1 Amino acid permease Phage_holin_3_5 PF16085.5 CCF33572.1 - 0.3 11.3 2.1 1.3 9.2 0.1 2.7 2 0 0 2 2 2 0 Bacteriophage holin Hol, superfamily III Sec1 PF00995.23 CCF33574.1 - 2.5e-116 390.2 0.0 2.9e-116 390.0 0.0 1.0 1 0 0 1 1 1 1 Sec1 family Trs65 PF12735.7 CCF33575.1 - 8.8e-129 429.4 0.0 9.9e-129 429.3 0.0 1.0 1 0 0 1 1 1 1 TRAPP trafficking subunit Trs65 SLD3 PF08639.10 CCF33576.1 - 1e-180 602.1 0.7 1e-180 602.1 0.7 2.0 2 0 0 2 2 2 1 DNA replication regulator SLD3 Glyco_transf_8 PF01501.20 CCF33577.1 - 0.0038 16.8 0.2 0.0043 16.7 0.2 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 8 Nop16 PF09420.10 CCF33578.1 - 2.4e-69 233.6 5.8 2.7e-69 233.4 5.8 1.0 1 0 0 1 1 1 1 Ribosome biogenesis protein Nop16 HTH_38 PF13936.6 CCF33578.1 - 0.0049 16.6 0.2 0.2 11.4 0.0 2.5 2 0 0 2 2 2 1 Helix-turn-helix domain MARVEL PF01284.23 CCF33579.1 - 8.8e-08 32.3 9.2 1.4e-07 31.6 9.2 1.3 1 0 0 1 1 1 1 Membrane-associating domain DUF4281 PF14108.6 CCF33579.1 - 0.00011 22.5 2.1 0.00014 22.2 1.5 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4281) Rit1_C PF17184.4 CCF33580.1 - 2.2e-108 361.9 0.0 2.7e-108 361.6 0.0 1.1 1 0 0 1 1 1 1 Rit1 N-terminal domain Init_tRNA_PT PF04179.12 CCF33580.1 - 3.1e-34 117.6 0.0 6.3e-34 116.6 0.0 1.5 1 0 0 1 1 1 1 Rit1 DUSP-like domain Thyroglobulin_1 PF00086.18 CCF33580.1 - 0.089 12.5 0.0 0.21 11.3 0.0 1.6 1 0 0 1 1 1 0 Thyroglobulin type-1 repeat DUF1996 PF09362.10 CCF33581.1 - 5.4e-81 272.0 0.0 7.4e-81 271.6 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) DUF1774 PF08611.10 CCF33582.1 - 1.9e-37 127.5 1.0 1.9e-37 127.5 1.0 2.6 2 1 0 3 3 3 1 Fungal protein of unknown function (DUF1774) Helicase_C PF00271.31 CCF33583.1 - 9.5e-15 54.9 0.0 2.2e-14 53.7 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-C3HC4_2 PF13923.6 CCF33583.1 - 5.1e-10 39.0 14.1 5.1e-10 39.0 14.1 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CCF33583.1 - 2e-09 37.2 12.1 2e-09 37.2 12.1 2.4 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CCF33583.1 - 5.9e-09 36.1 15.3 1.7e-08 34.7 13.3 2.2 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 CCF33583.1 - 1.7e-08 34.2 15.3 1.7e-08 34.2 15.3 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 CCF33583.1 - 3.9e-08 33.3 7.2 1.2e-07 31.7 7.4 1.8 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 CCF33583.1 - 7.4e-08 32.3 10.3 2e-07 30.9 10.3 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 CCF33583.1 - 2.1e-07 30.8 12.8 4.9e-07 29.6 12.8 1.7 1 0 0 1 1 1 1 zinc-RING finger domain SNF2_N PF00176.23 CCF33583.1 - 1.2e-06 27.5 0.2 1.9e-06 26.8 0.2 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Prok-RING_4 PF14447.6 CCF33583.1 - 1.3e-05 25.0 11.1 1.3e-05 25.0 11.1 2.0 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 CCF33583.1 - 5e-05 23.5 12.9 0.00021 21.5 12.9 2.0 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_6 PF14835.6 CCF33583.1 - 8.6e-05 22.3 3.1 0.0002 21.2 3.1 1.6 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-ANAPC11 PF12861.7 CCF33583.1 - 0.0011 19.0 3.8 0.0023 17.9 3.8 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.6 CCF33583.1 - 0.011 15.5 7.7 0.026 14.3 7.7 1.7 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-Nse PF11789.8 CCF33583.1 - 0.015 15.1 7.9 0.03 14.2 7.9 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_11 PF17123.5 CCF33583.1 - 0.25 11.1 11.1 0.41 10.4 9.8 2.2 2 0 0 2 2 2 0 RING-like zinc finger Vps39_2 PF10367.9 CCF33583.1 - 0.78 10.2 6.8 16 6.0 2.6 3.1 1 1 1 2 2 2 0 Vacuolar sorting protein 39 domain 2 zf-RING_10 PF16685.5 CCF33583.1 - 1.1 9.5 13.7 0.076 13.2 8.4 1.9 2 0 0 2 2 1 0 zinc RING finger of MSL2 DZR PF12773.7 CCF33583.1 - 1.1 9.4 5.9 2.4 8.2 5.9 1.6 1 0 0 1 1 1 0 Double zinc ribbon NPF PF16601.5 CCF33584.1 - 0.11 12.9 0.1 0.11 12.9 0.1 1.0 1 0 0 1 1 1 0 Rabosyn-5 repeating NPF sequence-motif F-box PF00646.33 CCF33585.1 - 2.4e-09 36.8 0.2 3.5e-09 36.3 0.2 1.2 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 CCF33585.1 - 7e-08 32.2 0.2 1.1e-07 31.6 0.2 1.3 1 0 0 1 1 1 1 F-box-like F-box_4 PF15966.5 CCF33585.1 - 0.00078 19.3 0.0 0.0011 18.8 0.0 1.2 1 0 0 1 1 1 1 F-box PRANC PF09372.10 CCF33585.1 - 0.17 12.2 0.0 0.26 11.6 0.0 1.2 1 0 0 1 1 1 0 PRANC domain Peptidase_S10 PF00450.22 CCF33586.1 - 3.2e-129 432.0 0.9 4e-129 431.7 0.9 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Carbpep_Y_N PF05388.11 CCF33586.1 - 6.8e-16 59.0 4.6 6e-15 55.9 4.6 2.3 1 1 0 1 1 1 1 Carboxypeptidase Y pro-peptide SBDS_C PF09377.10 CCF33587.1 - 1e-44 151.3 0.0 1.6e-44 150.6 0.0 1.3 1 0 0 1 1 1 1 SBDS protein C-terminal domain SBDS PF01172.18 CCF33587.1 - 1e-35 121.7 0.2 1.6e-35 121.1 0.2 1.3 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein Ribosomal_S13 PF00416.22 CCF33588.1 - 3.1e-54 182.8 3.0 3.6e-54 182.6 3.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S13/S18 FbpA PF05833.11 CCF33588.1 - 0.063 12.0 0.0 0.086 11.6 0.0 1.1 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) PP28 PF10252.9 CCF33588.1 - 0.078 13.4 0.3 0.18 12.3 0.3 1.6 1 0 0 1 1 1 0 Casein kinase substrate phosphoprotein PP28 GATase_2 PF00310.21 CCF33590.1 - 5.7e-182 605.1 0.0 8e-182 604.6 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Glu_synthase PF01645.17 CCF33590.1 - 2.5e-155 517.2 0.0 4.1e-155 516.5 0.0 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase Glu_syn_central PF04898.14 CCF33590.1 - 6.9e-112 373.5 0.0 5.2e-110 367.3 0.0 2.2 2 0 0 2 2 2 1 Glutamate synthase central domain GXGXG PF01493.19 CCF33590.1 - 6.5e-88 293.3 2.6 1.1e-87 292.5 2.6 1.4 1 0 0 1 1 1 1 GXGXG motif Pyr_redox_2 PF07992.14 CCF33590.1 - 1.5e-23 83.5 0.1 7.7e-23 81.1 0.1 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Fer4_20 PF14691.6 CCF33590.1 - 3.4e-21 75.1 0.1 7.1e-21 74.1 0.1 1.5 1 0 0 1 1 1 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster NAD_binding_8 PF13450.6 CCF33590.1 - 1.4e-08 34.9 0.0 4.5e-08 33.2 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CCF33590.1 - 2.6e-07 30.5 0.3 0.00062 19.4 0.2 2.6 2 0 0 2 2 2 2 FAD dependent oxidoreductase Amino_oxidase PF01593.24 CCF33590.1 - 1.9e-06 27.5 0.1 3.5e-06 26.6 0.1 1.5 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase Pyr_redox PF00070.27 CCF33590.1 - 2.8e-06 27.8 0.1 0.00058 20.4 0.0 3.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCF33590.1 - 1.7e-05 24.2 1.7 0.081 12.2 0.1 3.8 3 1 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CCF33590.1 - 8.4e-05 21.4 0.1 8.4e-05 21.4 0.1 1.7 2 0 0 2 2 2 1 HI0933-like protein FAD_oxidored PF12831.7 CCF33590.1 - 0.00017 21.1 0.1 0.00017 21.1 0.1 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 CCF33590.1 - 0.00041 19.7 0.0 0.00095 18.5 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain FAD_binding_2 PF00890.24 CCF33590.1 - 0.00082 18.6 3.4 0.00088 18.5 0.0 2.4 3 0 0 3 3 2 1 FAD binding domain AlaDh_PNT_C PF01262.21 CCF33590.1 - 0.0021 17.4 0.3 0.086 12.1 0.0 2.3 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_7 PF13241.6 CCF33590.1 - 0.0049 17.3 0.7 1.1 9.7 0.1 3.0 3 0 0 3 3 2 1 Putative NAD(P)-binding Thi4 PF01946.17 CCF33590.1 - 0.0065 15.7 0.5 0.022 14.0 0.0 2.1 2 0 0 2 2 2 1 Thi4 family Lycopene_cycl PF05834.12 CCF33590.1 - 0.0081 15.3 0.8 0.52 9.3 0.1 2.8 4 0 0 4 4 4 1 Lycopene cyclase protein NAD_Gly3P_dh_N PF01210.23 CCF33590.1 - 0.013 15.5 0.0 0.03 14.3 0.0 1.6 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus GIDA PF01134.22 CCF33590.1 - 0.014 14.5 0.5 0.14 11.3 0.0 2.3 2 0 0 2 2 2 0 Glucose inhibited division protein A FMN_dh PF01070.18 CCF33590.1 - 0.04 12.9 0.7 0.13 11.3 0.7 1.8 2 0 0 2 2 2 0 FMN-dependent dehydrogenase FMO-like PF00743.19 CCF33590.1 - 0.054 11.9 0.0 3.6 5.9 0.0 2.7 3 0 0 3 3 3 0 Flavin-binding monooxygenase-like 2-Hacid_dh_C PF02826.19 CCF33590.1 - 0.072 12.5 0.1 0.33 10.3 0.0 2.1 3 0 0 3 3 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AdoHcyase_NAD PF00670.21 CCF33590.1 - 0.13 12.4 0.2 9.1 6.3 0.1 2.8 2 0 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Rossmann-like PF10727.9 CCF33590.1 - 7.4 6.5 5.6 3.1 7.7 0.1 2.7 3 0 0 3 3 2 0 Rossmann-like domain Glyco_transf_90 PF05686.12 CCF33591.1 - 1.4e-05 24.2 0.0 2.3e-05 23.5 0.0 1.5 1 1 0 1 1 1 1 Glycosyl transferase family 90 zf-C2H2_jaz PF12171.8 CCF33592.1 - 0.0015 18.7 0.4 0.0061 16.8 0.4 2.1 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 CCF33592.1 - 0.0027 18.1 1.9 0.0027 18.1 1.9 3.9 3 0 0 3 3 3 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCF33592.1 - 0.0066 17.2 0.8 0.0066 17.2 0.8 4.6 4 0 0 4 4 4 1 C2H2-type zinc finger TipE PF16972.5 CCF33592.1 - 0.18 11.0 0.0 0.26 10.4 0.0 1.2 1 0 0 1 1 1 0 Na+ channel auxiliary subunit TipE p450 PF00067.22 CCF33593.1 - 1.4e-09 37.2 0.0 1.8e-09 36.9 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 MFS_1 PF07690.16 CCF33595.1 - 9.7e-34 116.8 11.5 9.7e-34 116.8 11.5 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily Holin_BhlA PF10960.8 CCF33595.1 - 0.16 11.9 0.0 0.46 10.5 0.0 1.7 1 0 0 1 1 1 0 BhlA holin family ThrE_2 PF12821.7 CCF33596.1 - 9.3e-12 45.2 14.0 9.3e-12 45.2 14.0 2.4 2 1 0 2 2 2 1 Threonine/Serine exporter, ThrE ThrE PF06738.12 CCF33596.1 - 1.6e-11 44.0 19.9 3.7e-07 29.7 0.2 3.0 2 1 1 3 3 3 2 Putative threonine/serine exporter DUF2651 PF10852.8 CCF33596.1 - 0.016 15.8 1.5 0.016 15.8 1.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2651) Intg_mem_TP0381 PF09529.10 CCF33596.1 - 0.025 14.1 7.4 0.046 13.2 7.4 1.4 1 0 0 1 1 1 0 Integral membrane protein (intg_mem_TP0381) bZIP_2 PF07716.15 CCF33600.1 - 9.8e-07 28.8 8.8 2.1e-06 27.7 8.7 1.6 1 1 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 CCF33600.1 - 7.5e-06 26.0 5.4 1.1e-05 25.4 5.4 1.3 1 0 0 1 1 1 1 bZIP transcription factor MDFI PF15316.6 CCF33600.1 - 0.0036 17.4 0.0 0.0042 17.2 0.0 1.1 1 0 0 1 1 1 1 MyoD family inhibitor Atg14 PF10186.9 CCF33600.1 - 0.03 13.4 0.2 0.034 13.2 0.2 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 UBA2_C PF16195.5 CCF33600.1 - 0.03 15.0 1.4 0.048 14.3 1.4 1.4 1 0 0 1 1 1 0 SUMO-activating enzyme subunit 2 C-terminus Phlebovirus_NSM PF07246.11 CCF33600.1 - 0.045 13.1 0.4 0.052 12.9 0.4 1.1 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M bZIP_Maf PF03131.17 CCF33600.1 - 0.045 14.3 5.3 0.082 13.4 5.3 1.4 1 0 0 1 1 1 0 bZIP Maf transcription factor HpcH_HpaI PF03328.14 CCF33601.1 - 1.6e-24 86.3 0.7 2.4e-24 85.7 0.7 1.3 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family SUD-M PF11633.8 CCF33601.1 - 0.11 12.2 0.9 2.3 7.9 0.1 2.3 2 0 0 2 2 2 0 Single-stranded poly(A) binding domain MFS_1 PF07690.16 CCF33602.1 - 1.2e-31 109.9 19.3 1.2e-31 109.9 19.3 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_1_like PF12832.7 CCF33602.1 - 0.0001 21.3 0.1 0.00024 20.1 0.1 1.7 1 1 0 1 1 1 1 MFS_1 like family Aminotran_1_2 PF00155.21 CCF33603.1 - 6.3e-16 58.5 0.0 9.4e-16 57.9 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 CCF33603.1 - 0.024 13.4 0.1 0.056 12.2 0.0 1.6 2 0 0 2 2 2 0 Alanine-glyoxylate amino-transferase Tannase PF07519.11 CCF33605.1 - 1.1e-90 304.8 0.0 1.3e-90 304.6 0.0 1.0 1 0 0 1 1 1 1 Tannase and feruloyl esterase Hydrolase_4 PF12146.8 CCF33605.1 - 2.5e-05 23.7 0.0 0.0063 15.8 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 CCF33605.1 - 9e-05 22.0 0.1 0.075 12.5 0.2 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 CCF33605.1 - 0.0018 18.0 0.1 0.0046 16.6 0.1 1.6 1 0 0 1 1 1 1 alpha/beta hydrolase fold UbiA PF01040.18 CCF33607.1 - 5.5e-11 42.2 2.7 6.4e-11 42.0 0.1 2.1 1 1 1 2 2 2 1 UbiA prenyltransferase family IQCJ-SCHIP1 PF15157.6 CCF33607.1 - 0.27 11.1 2.4 0.46 10.3 2.4 1.4 1 0 0 1 1 1 0 Fusion protein IQCJ-SCHIP1 with IQ-like motif RBR PF17208.3 CCF33607.1 - 8.7 7.1 7.2 53 4.6 1.3 3.0 2 0 0 2 2 2 0 RNA binding Region His_Phos_2 PF00328.22 CCF33609.1 - 2e-49 168.9 0.0 2.5e-49 168.7 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) API5 PF05918.11 CCF33610.1 - 0.0069 15.2 0.8 0.0089 14.9 0.8 1.1 1 0 0 1 1 1 1 Apoptosis inhibitory protein 5 (API5) Mucin PF01456.17 CCF33610.1 - 0.37 10.8 8.9 0.68 9.9 8.9 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein Asp PF00026.23 CCF33611.1 - 8.5e-32 110.8 0.0 1.1e-31 110.4 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCF33611.1 - 7e-07 29.7 0.1 0.32 11.2 0.1 3.5 2 1 1 3 3 3 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 CCF33611.1 - 0.021 15.5 0.0 3.8 8.2 0.0 2.8 2 1 0 2 2 2 0 Aspartyl protease Filament PF00038.21 CCF33612.1 - 0.0054 16.3 1.4 0.006 16.2 1.4 1.2 1 0 0 1 1 1 1 Intermediate filament protein DUF724 PF05266.14 CCF33612.1 - 0.008 16.0 0.7 0.0098 15.7 0.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF724) Peptidase_M61 PF05299.12 CCF33612.1 - 0.01 16.3 0.1 0.025 15.0 0.1 1.6 1 1 1 2 2 2 0 M61 glycyl aminopeptidase DASH_Spc34 PF08657.10 CCF33612.1 - 0.011 15.6 0.7 0.013 15.3 0.7 1.2 1 0 0 1 1 1 0 DASH complex subunit Spc34 CytochromB561_N PF09786.9 CCF33612.1 - 0.014 14.5 2.6 0.017 14.1 2.6 1.0 1 0 0 1 1 1 0 Cytochrome B561, N terminal FliD_N PF02465.18 CCF33612.1 - 0.027 15.2 2.7 0.045 14.5 2.7 1.3 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus SKA1 PF07160.12 CCF33612.1 - 0.028 14.3 0.7 0.033 14.0 0.7 1.1 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 Allexi_40kDa PF05549.11 CCF33612.1 - 0.031 13.8 0.5 0.035 13.6 0.5 1.2 1 0 0 1 1 1 0 Allexivirus 40kDa protein COG2 PF06148.11 CCF33612.1 - 0.036 14.2 0.2 0.046 13.8 0.2 1.1 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 Med2 PF11214.8 CCF33612.1 - 0.038 14.1 0.3 0.062 13.5 0.3 1.3 1 0 0 1 1 1 0 Mediator complex subunit 2 HeLo PF14479.6 CCF33612.1 - 0.044 13.6 0.9 0.054 13.3 0.9 1.1 1 0 0 1 1 1 0 Prion-inhibition and propagation DUF4407 PF14362.6 CCF33612.1 - 0.084 12.2 2.3 0.089 12.1 2.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SlyX PF04102.12 CCF33612.1 - 0.092 13.4 0.5 0.092 13.4 0.5 2.1 2 0 0 2 2 2 0 SlyX ABC_tran_CTD PF16326.5 CCF33612.1 - 0.25 11.6 4.2 0.52 10.6 4.2 1.6 1 1 0 1 1 1 0 ABC transporter C-terminal domain V_ATPase_I PF01496.19 CCF33612.1 - 0.3 9.0 0.5 0.31 8.9 0.5 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family FUSC PF04632.12 CCF33612.1 - 0.49 8.9 2.4 0.57 8.7 2.4 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family DivIC PF04977.15 CCF33612.1 - 3 7.7 5.9 1.4 8.7 3.6 1.6 2 0 0 2 2 2 0 Septum formation initiator DUF569 PF04601.13 CCF33614.1 - 0.056 13.1 0.0 0.064 13.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF569) DUF2861 PF11060.8 CCF33614.1 - 0.11 12.1 0.0 0.12 12.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2861) AMP-binding PF00501.28 CCF33616.1 - 2.2e-71 240.7 0.0 4.7e-71 239.6 0.0 1.5 2 0 0 2 2 2 1 AMP-binding enzyme AMP-binding_C PF13193.6 CCF33616.1 - 9.1e-11 42.6 0.1 2.2e-10 41.4 0.1 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Peptidase_M50B PF13398.6 CCF33617.1 - 6e-59 199.0 18.6 8.4e-59 198.6 18.6 1.2 1 0 0 1 1 1 1 Peptidase M50B-like Peptidase_M50 PF02163.22 CCF33617.1 - 0.029 13.7 0.0 0.051 12.8 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M50 ACR_tran PF00873.19 CCF33617.1 - 0.091 10.4 0.4 0.15 9.7 0.4 1.4 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family Aa_trans PF01490.18 CCF33619.1 - 1.5e-10 40.3 4.4 1.8e-10 40.1 4.4 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein p450 PF00067.22 CCF33620.1 - 3.3e-70 237.1 0.0 4.3e-70 236.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 RdRP PF05183.12 CCF33621.1 - 1.5e-180 601.7 0.0 2.3e-180 601.1 0.0 1.3 1 0 0 1 1 1 1 RNA dependent RNA polymerase DUF2884 PF11101.8 CCF33621.1 - 0.008 15.7 0.5 0.05 13.1 0.6 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2884) Abhydrolase_1 PF00561.20 CCF33622.1 - 5.2e-12 45.9 0.0 7.8e-12 45.4 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CCF33622.1 - 4e-05 23.0 0.0 6.8e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CCF33622.1 - 5.4e-05 23.9 0.0 0.00014 22.6 0.0 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family EthD PF07110.11 CCF33622.1 - 0.00017 22.7 0.1 0.3 12.3 0.0 2.6 2 0 0 2 2 2 2 EthD domain DUF4286 PF14114.6 CCF33622.1 - 0.00051 20.5 0.0 0.24 11.9 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF4286) Ndr PF03096.14 CCF33622.1 - 0.0072 15.1 0.0 0.013 14.3 0.0 1.3 1 0 0 1 1 1 1 Ndr family Esterase PF00756.20 CCF33622.1 - 0.068 12.8 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Putative esterase NCKAP5 PF15246.6 CCF33623.1 - 0.0081 15.8 1.3 0.01 15.5 1.3 1.1 1 0 0 1 1 1 1 Nck-associated protein 5, Peripheral clock protein DUF3622 PF12286.8 CCF33623.1 - 2.7 8.4 5.7 9.1 6.7 0.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3622) MPC PF03650.13 CCF33624.1 - 5.2e-48 161.8 0.4 5.2e-48 161.8 0.4 1.7 2 0 0 2 2 2 1 Mitochondrial pyruvate carriers L51_S25_CI-B8 PF05047.16 CCF33625.1 - 1.3e-12 47.5 0.0 1.7e-12 47.1 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain Helo_like_N PF17111.5 CCF33626.1 - 8e-78 260.6 2.0 4.7e-73 245.0 0.1 2.2 2 0 0 2 2 2 2 Fungal N-terminal domain of STAND proteins DASH_Dad2 PF08654.10 CCF33626.1 - 0.00024 21.5 1.6 0.0017 18.8 0.0 2.7 3 0 0 3 3 2 1 DASH complex subunit Dad2 GIDA PF01134.22 CCF33626.1 - 0.0051 15.9 1.0 0.011 14.9 0.1 2.0 2 0 0 2 2 2 1 Glucose inhibited division protein A DUF148 PF02520.17 CCF33626.1 - 0.0089 16.1 4.7 0.06 13.5 0.1 3.2 3 1 0 3 3 3 1 Domain of unknown function DUF148 DivIC PF04977.15 CCF33626.1 - 0.012 15.4 5.2 0.11 12.3 0.2 3.5 3 0 0 3 3 3 0 Septum formation initiator SCO1-SenC PF02630.14 CCF33626.1 - 0.012 15.5 0.1 0.035 14.0 0.1 1.7 1 0 0 1 1 1 0 SCO1/SenC CEP209_CC5 PF16574.5 CCF33626.1 - 0.026 14.7 0.1 0.11 12.7 0.1 2.0 1 0 0 1 1 1 0 Coiled-coil region of centrosome protein CE290 DUF2937 PF11157.8 CCF33626.1 - 0.032 14.0 0.8 0.17 11.6 0.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2937) COG2 PF06148.11 CCF33626.1 - 0.053 13.6 8.4 9.2 6.4 0.0 4.4 3 2 0 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF1664 PF07889.12 CCF33626.1 - 0.067 13.2 4.9 0.74 9.9 0.1 3.4 4 0 0 4 4 4 0 Protein of unknown function (DUF1664) TBCA PF02970.16 CCF33626.1 - 0.21 11.9 1.5 2.7 8.4 0.1 3.0 1 1 1 2 2 2 0 Tubulin binding cofactor A Baculo_PEP_C PF04513.12 CCF33626.1 - 0.34 10.9 7.5 21 5.2 1.1 3.6 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF848 PF05852.11 CCF33626.1 - 1.4 9.1 5.7 0.63 10.2 0.5 2.9 2 2 1 3 3 3 0 Gammaherpesvirus protein of unknown function (DUF848) FlgN PF05130.12 CCF33626.1 - 2 8.9 14.2 4.6 7.7 1.7 4.1 4 1 0 4 4 4 0 FlgN protein DUF5082 PF16888.5 CCF33626.1 - 3.3 8.0 5.9 3.4 8.0 0.2 3.3 2 1 2 4 4 4 0 Domain of unknown function (DUF5082) KfrA_N PF11740.8 CCF33626.1 - 7.3 7.3 9.1 1 10.1 1.1 3.1 2 1 1 3 3 3 0 Plasmid replication region DNA-binding N-term Helo_like_N PF17111.5 CCF33627.1 - 3.3e-75 252.0 6.4 2e-73 246.3 1.6 2.2 2 0 0 2 2 2 2 Fungal N-terminal domain of STAND proteins AA_permease_2 PF13520.6 CCF33628.1 - 4.6e-89 299.2 31.3 5.6e-89 298.9 31.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CCF33628.1 - 2.2e-22 79.3 27.7 3.1e-22 78.8 27.7 1.1 1 0 0 1 1 1 1 Amino acid permease DUF3632 PF12311.8 CCF33630.1 - 1.1e-16 61.8 1.7 1.5e-16 61.3 0.2 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF3632) MFS_1 PF07690.16 CCF33631.1 - 3.3e-18 65.8 87.8 4.2e-16 58.8 46.1 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily GFA PF04828.14 CCF33632.1 - 4.8e-22 78.1 0.5 6.8e-22 77.6 0.5 1.2 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme NOB1_Zn_bind PF08772.11 CCF33632.1 - 0.11 12.7 1.8 1.2 9.3 0.0 2.2 2 0 0 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like AAR2 PF05282.11 CCF33633.1 - 0.0079 15.6 0.0 0.0085 15.5 0.0 1.1 1 0 0 1 1 1 1 AAR2 protein Secretin_N_2 PF07655.13 CCF33633.1 - 0.45 11.1 6.7 0.78 10.3 6.7 1.3 1 0 0 1 1 1 0 Secretin N-terminal domain PS-DH PF14765.6 CCF33634.1 - 2.8e-60 204.1 0.0 4.6e-60 203.4 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase KR PF08659.10 CCF33634.1 - 3.6e-55 186.7 0.0 2.7e-54 183.8 0.0 2.4 2 0 0 2 2 2 1 KR domain Methyltransf_12 PF08242.12 CCF33634.1 - 2.8e-19 69.7 0.0 7.6e-19 68.3 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain ADH_zinc_N_2 PF13602.6 CCF33634.1 - 6e-19 69.4 0.0 1.7e-16 61.5 0.0 2.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 CCF33634.1 - 1.3e-15 57.5 0.6 2.6e-14 53.3 0.1 2.9 3 0 0 3 3 3 1 Zinc-binding dehydrogenase Methyltransf_23 PF13489.6 CCF33634.1 - 5.9e-12 45.7 0.0 1.1e-11 44.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain adh_short PF00106.25 CCF33634.1 - 1e-10 41.4 0.0 2.2e-07 30.5 0.0 2.7 2 0 0 2 2 2 2 short chain dehydrogenase Methyltransf_25 PF13649.6 CCF33634.1 - 2.3e-10 41.1 0.0 8.5e-10 39.2 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF33634.1 - 4.1e-09 37.0 0.0 1.8e-08 34.9 0.0 2.2 2 0 0 2 2 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCF33634.1 - 4e-06 26.4 0.1 8.6e-06 25.2 0.1 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family adh_short_C2 PF13561.6 CCF33634.1 - 6.2e-06 25.9 0.0 0.00048 19.8 0.0 2.8 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Methyltransf_31 PF13847.6 CCF33634.1 - 9.3e-06 25.5 0.0 3.6e-05 23.6 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain PP-binding PF00550.25 CCF33634.1 - 0.00018 21.8 0.1 0.00041 20.6 0.1 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site Methyltransf_16 PF10294.9 CCF33634.1 - 0.00051 19.8 0.0 0.0011 18.7 0.0 1.5 1 0 0 1 1 1 1 Lysine methyltransferase ADH_N PF08240.12 CCF33634.1 - 0.018 14.9 0.0 0.039 13.8 0.0 1.5 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain Sacchrp_dh_NADP PF03435.18 CCF33634.1 - 0.022 15.0 0.1 0.15 12.3 0.0 2.2 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain 2-Hacid_dh_C PF02826.19 CCF33634.1 - 0.075 12.4 0.0 1.5 8.1 0.0 2.5 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Methyltransf_8 PF05148.15 CCF33634.1 - 0.093 12.6 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 Hypothetical methyltransferase Glyco_hydro_42M PF08532.10 CCF33634.1 - 0.096 12.2 0.0 0.58 9.6 0.0 2.1 2 0 0 2 2 2 0 Beta-galactosidase trimerisation domain PGM_PMM_I PF02878.16 CCF33635.1 - 4.6e-34 117.1 0.0 5.8e-34 116.8 0.0 1.1 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 CCF33635.1 - 0.0076 16.9 0.0 0.014 16.0 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II RNase_T PF00929.24 CCF33636.1 - 2.3e-22 80.3 0.0 2.8e-22 80.0 0.0 1.1 1 0 0 1 1 1 1 Exonuclease GFO_IDH_MocA PF01408.22 CCF33637.1 - 2.2e-11 44.6 0.0 6.7e-11 43.1 0.0 1.8 1 1 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 CCF33637.1 - 0.00024 21.1 0.0 0.00059 19.8 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain ImpA_N PF06812.12 CCF33637.1 - 0.042 13.9 0.4 0.16 12.1 0.0 2.1 3 0 0 3 3 3 0 ImpA, N-terminal, type VI secretion system DUF2464 PF10240.9 CCF33638.1 - 0.021 14.4 0.0 0.037 13.6 0.0 1.3 1 0 0 1 1 1 0 Multivesicular body subunit 12 DUF3336 PF11815.8 CCF33639.1 - 6.6e-36 123.1 0.1 1.7e-34 118.5 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF3336) Patatin PF01734.22 CCF33639.1 - 1.2e-12 48.5 0.2 3.4e-12 47.0 0.2 1.8 1 0 0 1 1 1 1 Patatin-like phospholipase Leo1 PF04004.13 CCF33640.1 - 6.2e-35 120.5 0.0 1e-34 119.7 0.0 1.4 1 0 0 1 1 1 1 Leo1-like protein Epimerase PF01370.21 CCF33642.1 - 6.2e-21 75.0 0.0 8.2e-21 74.6 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CCF33642.1 - 1.5e-17 63.5 0.0 2.4e-17 62.8 0.0 1.4 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 CCF33642.1 - 1.2e-12 47.9 0.0 1.8e-12 47.3 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 CCF33642.1 - 1.9e-12 46.9 0.0 9.4e-12 44.6 0.0 1.9 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 CCF33642.1 - 2e-10 40.8 0.0 3.1e-10 40.2 0.0 1.4 1 1 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 CCF33642.1 - 1.5e-06 28.0 0.0 0.00035 20.2 0.0 2.2 2 0 0 2 2 2 2 NmrA-like family KR PF08659.10 CCF33642.1 - 0.00095 19.1 0.1 0.0037 17.2 0.1 1.9 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 CCF33642.1 - 0.0032 16.7 0.0 0.0055 15.9 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.25 CCF33642.1 - 0.1 12.1 0.0 0.19 11.2 0.0 1.4 1 0 0 1 1 1 0 short chain dehydrogenase DUF1996 PF09362.10 CCF33644.1 - 1.3e-46 159.5 0.5 1.6e-46 159.2 0.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) GFA PF04828.14 CCF33645.1 - 1.2e-15 57.6 2.7 1.9e-15 57.0 2.7 1.3 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme Chromate_transp PF02417.15 CCF33647.1 - 2.9e-17 63.2 0.0 3.3e-17 63.1 0.0 1.1 1 0 0 1 1 1 1 Chromate transporter RabGAP-TBC PF00566.18 CCF33648.1 - 1.1e-27 97.1 0.0 2.1e-27 96.2 0.0 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain SBE2 PF17076.5 CCF33648.1 - 3e-09 35.7 0.0 3e-09 35.7 0.0 1.8 2 0 0 2 2 2 1 SBE2, cell-wall formation DOCK_N PF16172.5 CCF33650.1 - 1e-122 409.7 0.0 1.6e-122 409.1 0.0 1.3 1 0 0 1 1 1 1 DOCK N-terminus DOCK-C2 PF14429.6 CCF33650.1 - 5.1e-37 127.6 0.0 9.4e-37 126.7 0.0 1.5 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins DHR-2 PF06920.13 CCF33650.1 - 1.6e-30 106.3 5.6 2.4e-30 105.7 2.4 2.3 2 1 0 2 2 2 1 Dock homology region 2 SH3_1 PF00018.28 CCF33650.1 - 1.9e-05 24.1 0.0 4.5e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 CCF33650.1 - 0.0018 18.1 0.0 0.01 15.7 0.0 2.3 2 0 0 2 2 2 1 Variant SH3 domain GCIP PF13324.6 CCF33650.1 - 0.029 14.0 2.0 0.069 12.8 2.0 1.6 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting Spt5_N PF11942.8 CCF33650.1 - 0.039 14.9 2.2 0.1 13.6 2.2 1.7 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal Sugar_tr PF00083.24 CCF33651.1 - 2.6e-41 141.9 4.9 3e-41 141.7 4.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF33651.1 - 6.8e-14 51.6 11.7 8.9e-14 51.2 11.7 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.6 CCF33651.1 - 1.6e-05 23.7 0.6 2.7e-05 22.9 0.3 1.5 2 0 0 2 2 2 1 MFS/sugar transport protein MFS_4 PF06779.14 CCF33651.1 - 0.00019 20.9 1.7 0.00028 20.3 1.7 1.2 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB Romo1 PF10247.9 CCF33651.1 - 0.096 13.1 4.5 0.056 13.8 2.1 2.0 1 1 1 2 2 2 0 Reactive mitochondrial oxygen species modulator 1 Fungal_trans PF04082.18 CCF33652.1 - 4.1e-08 32.6 0.1 7.1e-08 31.8 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain CH_2 PF06294.11 CCF33652.1 - 0.074 13.2 0.0 0.14 12.3 0.0 1.4 1 0 0 1 1 1 0 CH-like domain in sperm protein MFS_1 PF07690.16 CCF33653.1 - 9e-28 97.2 36.9 9e-28 97.2 36.9 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily DIOX_N PF14226.6 CCF33654.1 - 9.8e-17 61.8 0.1 1.8e-16 60.9 0.1 1.4 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 CCF33654.1 - 8.3e-05 23.0 0.0 0.00018 22.0 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily zf-C3HC4 PF00097.25 CCF33655.1 - 8.9e-07 28.7 7.6 5.4e-06 26.2 8.2 1.9 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CCF33655.1 - 1e-06 28.7 6.3 4.1e-06 26.7 6.3 2.0 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 CCF33655.1 - 1.2e-06 28.2 7.8 3.2e-06 26.9 3.9 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CCF33655.1 - 1.3e-06 28.3 10.1 2.5e-06 27.3 10.1 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 CCF33655.1 - 2.2e-06 27.9 10.8 3.8e-06 27.1 10.8 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 CCF33655.1 - 6.2e-06 26.0 7.6 1.1e-05 25.1 7.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 CCF33655.1 - 3e-05 24.1 6.9 4.3e-05 23.6 5.9 1.8 2 1 0 2 2 1 1 zinc finger of C3HC4-type, RING zf-4CXXC_R1 PF10497.9 CCF33655.1 - 0.025 14.8 2.3 0.053 13.7 2.3 1.5 1 0 0 1 1 1 0 Zinc-finger domain of monoamine-oxidase A repressor R1 Pox_Ag35 PF03286.14 CCF33655.1 - 0.12 12.1 0.1 0.18 11.6 0.1 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein zf-rbx1 PF12678.7 CCF33655.1 - 0.13 12.6 7.9 0.3 11.4 7.9 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain FYVE PF01363.21 CCF33655.1 - 0.22 11.7 5.7 0.43 10.7 5.7 1.5 1 0 0 1 1 1 0 FYVE zinc finger Prok-RING_4 PF14447.6 CCF33655.1 - 0.44 10.5 11.6 0.95 9.4 10.3 2.1 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 CCF33655.1 - 0.65 9.8 9.0 2.3 8.1 8.4 2.1 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain DUF747 PF05346.11 CCF33656.1 - 7.2e-121 403.5 9.9 8.9e-121 403.2 9.9 1.1 1 0 0 1 1 1 1 Eukaryotic membrane protein family DUF1761 PF08570.10 CCF33656.1 - 0.84 9.9 5.5 0.51 10.6 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1761) HemY_N PF07219.13 CCF33656.1 - 1.8 8.8 10.1 7.4 6.8 2.4 2.7 2 0 0 2 2 2 0 HemY protein N-terminus DLH PF01738.18 CCF33657.1 - 1.5e-27 96.5 0.0 1.8e-27 96.3 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Peptidase_S9 PF00326.21 CCF33657.1 - 0.027 13.9 0.0 0.066 12.7 0.0 1.6 2 0 0 2 2 2 0 Prolyl oligopeptidase family SLATT_5 PF18160.1 CCF33658.1 - 0.16 11.3 0.2 0.32 10.3 0.2 1.4 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 p450 PF00067.22 CCF33660.1 - 7.7e-20 71.1 0.0 1.8e-19 69.8 0.0 1.5 1 1 0 1 1 1 1 Cytochrome P450 BTB PF00651.31 CCF33661.1 - 0.0036 17.5 0.0 0.0069 16.6 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain LETM1 PF07766.13 CCF33662.1 - 9.6e-10 38.2 0.3 7e-09 35.4 0.1 2.0 2 0 0 2 2 2 1 LETM1-like protein DLH PF01738.18 CCF33663.1 - 2.3e-15 56.8 0.0 3e-15 56.4 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_3 PF07859.13 CCF33663.1 - 0.0024 17.7 0.7 0.037 13.9 0.0 2.0 2 0 0 2 2 2 1 alpha/beta hydrolase fold BAAT_C PF08840.11 CCF33663.1 - 0.012 15.5 0.1 1.7 8.5 0.0 2.1 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Tcell_CD4_C PF12104.8 CCF33663.1 - 0.047 13.6 0.6 0.094 12.7 0.6 1.4 1 0 0 1 1 1 0 T cell CD4 receptor C terminal region Abhydrolase_2 PF02230.16 CCF33663.1 - 0.1 12.4 0.0 0.13 12.1 0.0 1.1 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase SNF2_N PF00176.23 CCF33664.1 - 2e-15 56.4 0.0 3.3e-14 52.4 0.0 2.4 1 1 0 1 1 1 1 SNF2 family N-terminal domain DNA_methylase PF00145.17 CCF33664.1 - 6.3e-14 52.1 0.0 1.5e-13 50.9 0.0 1.6 1 0 0 1 1 1 1 C-5 cytosine-specific DNA methylase zf-C3HC4 PF00097.25 CCF33664.1 - 0.0026 17.6 8.3 0.0074 16.1 8.3 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 CCF33664.1 - 0.036 14.2 1.7 0.14 12.3 1.7 2.0 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 CCF33664.1 - 0.074 12.9 8.3 0.22 11.4 8.3 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 CCF33664.1 - 0.13 12.1 6.6 0.3 10.9 6.6 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain SF3A3 PF16837.5 CCF33665.1 - 1.6e-27 95.8 4.1 8.3e-27 93.5 1.3 2.3 2 0 0 2 2 2 1 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 SF3a60_bindingd PF12108.8 CCF33665.1 - 6.2e-12 45.2 0.3 1.5e-11 44.0 0.3 1.7 1 0 0 1 1 1 1 Splicing factor SF3a60 binding domain zf-met PF12874.7 CCF33665.1 - 6.2e-07 29.6 0.2 1.1e-06 28.8 0.2 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 CCF33665.1 - 1e-06 28.9 0.2 1.8e-06 28.1 0.2 1.4 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding PRP9_N PF16958.5 CCF33665.1 - 9.1e-05 22.5 7.6 0.022 14.8 0.8 2.6 2 1 1 3 3 3 2 Pre-mRNA-splicing factor PRP9 N-terminus zf-C2H2_2 PF12756.7 CCF33665.1 - 0.026 14.9 0.1 0.082 13.3 0.1 1.8 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-HYPF PF07503.12 CCF33665.1 - 0.15 11.9 0.3 0.36 10.6 0.3 1.7 1 0 0 1 1 1 0 HypF finger DEAD PF00270.29 CCF33666.1 - 7.7e-42 143.0 0.1 1.3e-41 142.3 0.1 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF33666.1 - 2.7e-33 114.6 0.0 9.7e-33 112.8 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_30 PF13604.6 CCF33666.1 - 0.0005 19.8 0.1 0.00075 19.3 0.1 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CCF33666.1 - 0.0014 18.9 0.1 0.012 16.0 0.1 2.2 2 0 0 2 2 2 1 AAA domain ResIII PF04851.15 CCF33666.1 - 0.0023 18.0 0.0 0.0045 17.0 0.0 1.5 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DUF5393 PF17371.2 CCF33666.1 - 0.053 11.7 0.1 0.084 11.0 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5393) Flavi_DEAD PF07652.14 CCF33666.1 - 0.054 13.5 0.2 0.18 11.8 0.0 2.0 2 1 0 2 2 2 0 Flavivirus DEAD domain TniB PF05621.11 CCF33666.1 - 0.068 12.6 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein Helicase_RecD PF05127.14 CCF33666.1 - 0.081 12.8 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 Helicase AAA_22 PF13401.6 CCF33666.1 - 0.17 12.2 1.0 0.82 9.9 1.0 2.0 1 1 0 1 1 1 0 AAA domain SLATT_5 PF18160.1 CCF33667.1 - 0.05 12.9 0.1 0.05 12.9 0.1 2.5 2 1 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 DUF373 PF04123.13 CCF33667.1 - 7.6 5.9 11.3 0.96 8.8 6.8 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF373) F-box-like PF12937.7 CCF33669.1 - 3.2e-07 30.1 0.0 6.2e-07 29.2 0.0 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCF33669.1 - 6e-06 26.0 0.1 1.5e-05 24.8 0.1 1.7 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 CCF33669.1 - 0.057 13.3 0.2 0.14 12.1 0.0 1.6 2 0 0 2 2 2 0 F-box 4HBT PF03061.22 CCF33670.1 - 4.1e-13 49.5 0.0 5.6e-13 49.0 0.0 1.2 1 0 0 1 1 1 1 Thioesterase superfamily 4HBT_3 PF13622.6 CCF33670.1 - 3e-06 27.7 0.0 4.7e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 Thioesterase-like superfamily Pex2_Pex12 PF04757.14 CCF33671.1 - 1.4e-51 175.2 3.2 1.8e-51 174.9 3.2 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_4 PF15227.6 CCF33671.1 - 0.00071 19.7 3.0 0.0012 18.9 3.0 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 CCF33671.1 - 0.0018 18.1 3.5 0.0033 17.3 3.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CCF33671.1 - 0.0039 17.0 1.8 0.0061 16.4 1.8 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CCF33671.1 - 0.01 16.2 3.6 0.017 15.5 3.6 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 CCF33671.1 - 0.12 12.3 2.6 0.21 11.5 2.6 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CCF33671.1 - 0.15 12.1 2.2 0.26 11.3 2.2 1.5 1 0 0 1 1 1 0 RING-type zinc-finger Glyco_hydro_16 PF00722.21 CCF33672.1 - 1.3e-06 28.0 0.0 4.6e-06 26.2 0.0 1.8 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 Peptidase_M13_N PF05649.13 CCF33674.1 - 3.1e-96 323.4 0.0 1.2e-95 321.5 0.0 1.8 2 0 0 2 2 2 1 Peptidase family M13 Peptidase_M13 PF01431.21 CCF33674.1 - 2.9e-62 209.9 0.3 2.9e-62 209.9 0.3 1.6 2 0 0 2 2 2 1 Peptidase family M13 NPCC PF08058.11 CCF33675.1 - 1.4 9.0 4.5 6.4 6.8 4.5 2.2 1 1 0 1 1 1 0 Nuclear pore complex component FeoB_C PF07664.12 CCF33675.1 - 3.4 7.4 10.0 4.9 6.9 0.2 3.7 3 0 0 3 3 3 0 Ferrous iron transport protein B C terminus Gag_p15 PF08723.10 CCF33677.1 - 0.17 12.1 0.0 0.22 11.7 0.0 1.2 1 0 0 1 1 1 0 Gag protein p15 Na_Ca_ex PF01699.24 CCF33678.1 - 2e-24 86.3 31.4 6.8e-14 52.1 10.6 2.5 3 0 0 3 3 3 2 Sodium/calcium exchanger protein DUF2206 PF09971.9 CCF33678.1 - 0.17 10.6 2.0 1.4 7.6 0.0 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2206) PUNUT PF16913.5 CCF33678.1 - 0.58 9.3 11.8 0.81 8.8 1.5 3.7 4 0 0 4 4 4 0 Purine nucleobase transmembrane transport ATE_C PF04377.15 CCF33679.1 - 2e-46 157.9 1.7 2.2e-46 157.8 0.4 1.8 2 0 0 2 2 2 1 Arginine-tRNA-protein transferase, C terminus ATE_N PF04376.13 CCF33679.1 - 6.5e-19 68.1 0.4 1.5e-18 67.0 0.4 1.7 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, N terminus Acetyltransf_6 PF13480.7 CCF33679.1 - 0.28 11.3 4.5 0.34 11.0 0.2 3.0 4 0 0 4 4 4 0 Acetyltransferase (GNAT) domain Methyltransf_23 PF13489.6 CCF33680.1 - 1.3e-21 77.1 0.0 2.2e-21 76.4 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF33680.1 - 4.5e-12 46.5 0.0 1.3e-11 45.1 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF33680.1 - 5.8e-09 36.5 0.0 3.6e-08 33.9 0.0 2.3 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF33680.1 - 2.1e-08 34.8 0.0 1.6e-07 32.0 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF33680.1 - 6.5e-07 29.3 0.0 0.0012 18.7 0.0 2.5 3 0 0 3 3 3 2 Methyltransferase domain Ubie_methyltran PF01209.18 CCF33680.1 - 0.00097 18.5 0.0 0.53 9.6 0.0 2.2 2 0 0 2 2 2 2 ubiE/COQ5 methyltransferase family MTS PF05175.14 CCF33680.1 - 0.0019 17.8 0.0 0.0052 16.3 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_4 PF02390.17 CCF33680.1 - 0.0056 16.2 0.0 0.01 15.3 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_16 PF10294.9 CCF33680.1 - 0.013 15.2 0.0 0.021 14.6 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase PrmA PF06325.13 CCF33680.1 - 0.016 14.6 0.0 0.029 13.7 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) DUF938 PF06080.12 CCF33680.1 - 0.12 12.2 0.0 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Arylsulfotran_2 PF14269.6 CCF33681.1 - 3.3e-46 158.0 0.0 4.6e-46 157.5 0.0 1.1 1 0 0 1 1 1 1 Arylsulfotransferase (ASST) Arylsulfotrans PF05935.11 CCF33681.1 - 4e-20 72.1 0.0 3.2e-18 65.8 0.0 2.2 1 1 0 1 1 1 1 Arylsulfotransferase (ASST) DUF4690 PF15756.5 CCF33682.1 - 3 8.5 5.8 1 10.0 1.3 2.4 3 0 0 3 3 3 0 Small Novel Rich in Cartilage V-ATPase_H_N PF03224.14 CCF33683.1 - 2.8e-75 253.5 0.0 3.9e-75 253.1 0.0 1.2 1 0 0 1 1 1 1 V-ATPase subunit H V-ATPase_H_C PF11698.8 CCF33683.1 - 4e-36 123.7 0.0 1.9e-35 121.5 0.0 2.2 2 0 0 2 2 2 1 V-ATPase subunit H UNC45-central PF11701.8 CCF33683.1 - 0.05 13.6 0.0 0.13 12.2 0.0 1.7 1 0 0 1 1 1 0 Myosin-binding striated muscle assembly central Ribul_P_3_epim PF00834.19 CCF33684.1 - 2.5e-59 200.0 0.0 1.3e-58 197.6 0.0 1.9 1 1 0 1 1 1 1 Ribulose-phosphate 3 epimerase family ThiG PF05690.14 CCF33684.1 - 0.017 14.4 0.2 0.025 13.9 0.2 1.2 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG QRPTase_C PF01729.19 CCF33684.1 - 0.021 14.6 0.0 0.034 13.9 0.0 1.3 1 0 0 1 1 1 0 Quinolinate phosphoribosyl transferase, C-terminal domain OMPdecase PF00215.24 CCF33684.1 - 0.043 13.4 0.4 0.077 12.6 0.0 1.5 2 0 0 2 2 2 0 Orotidine 5'-phosphate decarboxylase / HUMPS family Pro_dh PF01619.18 CCF33687.1 - 8.8e-63 212.6 0.0 1.1e-62 212.3 0.0 1.1 1 0 0 1 1 1 1 Proline dehydrogenase DUF2156 PF09924.9 CCF33687.1 - 0.057 12.4 0.0 5.2 6.0 0.0 2.5 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2156) Flavin_Reduct PF01613.18 CCF33688.1 - 3e-11 43.6 0.0 4.1e-11 43.2 0.0 1.1 1 0 0 1 1 1 1 Flavin reductase like domain SET PF00856.28 CCF33689.1 - 1.1e-15 58.5 1.0 1.1e-15 58.5 1.0 2.7 3 1 0 3 3 3 1 SET domain AWS PF17907.1 CCF33689.1 - 5.7e-08 32.7 6.4 1.6e-07 31.3 6.4 1.7 1 0 0 1 1 1 1 AWS domain CRAL_TRIO PF00650.20 CCF33691.1 - 1.7e-12 47.4 0.0 2.4e-12 46.9 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 CCF33691.1 - 4.4e-06 26.8 0.0 8.7e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain RRM_1 PF00076.22 CCF33692.1 - 0.038 13.8 0.1 0.095 12.5 0.1 1.8 1 1 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HPIH PF13323.6 CCF33693.1 - 7.1e-33 113.7 0.4 8.7e-33 113.4 0.4 1.1 1 0 0 1 1 1 1 N-terminal domain with HPIH motif Isochorismatase PF00857.20 CCF33694.1 - 1.8e-27 96.6 0.1 2.9e-27 96.0 0.1 1.3 1 1 0 1 1 1 1 Isochorismatase family S1-P1_nuclease PF02265.16 CCF33695.1 - 4.7e-16 59.4 0.4 5.2e-16 59.2 0.4 1.0 1 0 0 1 1 1 1 S1/P1 Nuclease RPAP1_C PF08620.10 CCF33696.1 - 5.5e-27 93.7 0.0 9.5e-27 92.9 0.0 1.4 1 0 0 1 1 1 1 RPAP1-like, C-terminal RPAP1_N PF08621.10 CCF33696.1 - 2.1e-18 65.8 6.3 2.1e-18 65.8 6.3 1.7 2 0 0 2 2 2 1 RPAP1-like, N-terminal Phage_holin_2_3 PF16080.5 CCF33697.1 - 0.078 12.7 0.3 3.9 7.3 0.1 2.7 2 0 0 2 2 2 0 Bacteriophage holin family HP1 Calsarcin PF05556.11 CCF33698.1 - 0.11 12.1 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 Calcineurin-binding protein (Calsarcin) Rubella_E1 PF05748.11 CCF33698.1 - 0.11 11.4 0.0 0.13 11.2 0.0 1.0 1 0 0 1 1 1 0 Rubella membrane glycoprotein E1 Cutinase PF01083.22 CCF33699.1 - 1e-40 139.6 0.4 1.2e-40 139.4 0.4 1.0 1 0 0 1 1 1 1 Cutinase PE-PPE PF08237.11 CCF33699.1 - 0.00036 20.2 0.0 0.00052 19.6 0.0 1.3 1 0 0 1 1 1 1 PE-PPE domain Hydrolase_4 PF12146.8 CCF33699.1 - 0.0021 17.4 0.0 0.003 16.9 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CCF33699.1 - 0.052 14.2 0.0 0.053 14.1 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Wtap PF17098.5 CCF33700.1 - 0.043 13.8 0.6 0.06 13.3 0.6 1.3 1 0 0 1 1 1 0 WTAP/Mum2p family ATP-synt_B PF00430.18 CCF33700.1 - 0.07 13.2 0.5 0.07 13.2 0.5 1.5 2 0 0 2 2 2 0 ATP synthase B/B' CF(0) PE PF00934.20 CCF33700.1 - 0.13 12.6 1.0 0.22 11.9 1.0 1.4 1 0 0 1 1 1 0 PE family Velvet PF11754.8 CCF33701.1 - 6.5e-50 170.4 0.6 1.1e-32 114.0 0.0 3.5 2 2 1 3 3 3 2 Velvet factor Dynamin_N PF00350.23 CCF33702.1 - 0.18 11.8 0.0 0.24 11.4 0.0 1.2 1 0 0 1 1 1 0 Dynamin family Pkinase PF00069.25 CCF33703.1 - 1.9e-23 83.2 0.0 6.7e-13 48.6 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCF33703.1 - 4.6e-08 32.7 0.0 0.00018 20.9 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase p450 PF00067.22 CCF33704.1 - 1.6e-54 185.4 0.0 2.2e-54 185.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 TPR_11 PF13414.6 CCF33707.1 - 5e-14 51.7 0.3 8.4e-06 25.4 0.0 4.0 3 1 1 4 4 4 3 TPR repeat TPR_14 PF13428.6 CCF33707.1 - 4.6e-11 42.6 5.1 4.5e-05 23.9 0.5 5.3 4 1 2 6 6 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 CCF33707.1 - 2.2e-09 37.7 4.1 1.4e-07 31.9 0.2 3.7 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 CCF33707.1 - 1.5e-08 34.2 0.2 0.0017 18.4 0.1 4.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 CCF33707.1 - 7.4e-08 31.9 4.1 9.3e-05 22.3 0.2 4.9 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_16 PF13432.6 CCF33707.1 - 1.6e-07 31.8 1.3 0.00013 22.6 0.4 3.4 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 CCF33707.1 - 2.2e-07 30.9 0.7 5.9e-06 26.3 0.1 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 CCF33707.1 - 1.6e-06 28.1 0.4 0.0012 19.1 0.1 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 CCF33707.1 - 8.5e-06 25.4 1.3 0.00037 20.2 0.1 3.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 CCF33707.1 - 0.00017 21.8 4.3 0.4 11.0 0.3 3.9 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_20 PF14561.6 CCF33707.1 - 0.00018 21.8 2.7 0.008 16.5 0.1 3.4 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 CCF33707.1 - 0.00063 20.2 0.8 2.7 8.8 0.1 4.1 4 0 0 4 4 3 1 Tetratricopeptide repeat FAT PF02259.23 CCF33707.1 - 0.00067 19.0 0.1 0.00097 18.4 0.1 1.4 1 0 0 1 1 1 1 FAT domain TPR_7 PF13176.6 CCF33707.1 - 0.013 15.5 1.6 0.19 11.9 0.1 3.0 3 0 0 3 3 2 0 Tetratricopeptide repeat ChAPs PF09295.10 CCF33707.1 - 0.015 14.4 0.1 0.02 13.9 0.1 1.2 1 0 0 1 1 1 0 ChAPs (Chs5p-Arf1p-binding proteins) Wzy_C_2 PF11846.8 CCF33707.1 - 0.021 14.7 0.0 0.71 9.8 0.0 2.2 2 0 0 2 2 2 0 Virulence factor membrane-bound polymerase, C-terminal Methyltransf_1N PF02870.15 CCF33707.1 - 0.043 14.6 0.1 0.2 12.5 0.0 2.2 2 0 0 2 2 2 0 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain ANAPC3 PF12895.7 CCF33707.1 - 0.044 14.0 0.2 0.14 12.4 0.0 1.9 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 BTAD PF03704.17 CCF33707.1 - 0.078 13.4 2.1 0.95 9.9 0.0 3.0 2 1 0 3 3 3 0 Bacterial transcriptional activator domain Methyltransf_12 PF08242.12 CCF33708.1 - 3.7e-15 56.5 0.1 1.2e-14 54.8 0.0 1.9 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF33708.1 - 2e-14 54.1 0.0 4.7e-14 52.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF33708.1 - 6.1e-11 42.8 0.0 1.2e-10 41.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF33708.1 - 2.1e-10 40.7 0.0 3.4e-10 40.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF33708.1 - 1.9e-07 31.0 0.0 3.3e-07 30.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCF33708.1 - 3.3e-06 26.6 0.0 5.2e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_24 PF13578.6 CCF33708.1 - 2.2e-05 25.4 0.0 5.7e-05 24.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CCF33708.1 - 0.00084 18.9 0.0 0.0014 18.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_8 PF05148.15 CCF33708.1 - 0.0011 18.9 0.0 0.042 13.7 0.0 2.3 1 1 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_32 PF13679.6 CCF33708.1 - 0.0066 16.5 0.0 0.014 15.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain DUF3419 PF11899.8 CCF33708.1 - 0.017 14.3 0.0 0.027 13.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3419) NNMT_PNMT_TEMT PF01234.17 CCF33708.1 - 0.035 13.3 0.0 4.1 6.5 0.0 2.3 1 1 1 2 2 2 0 NNMT/PNMT/TEMT family PrmA PF06325.13 CCF33708.1 - 0.097 12.0 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Y_phosphatase3 PF13350.6 CCF33709.1 - 2.5e-33 116.0 0.0 4.3e-32 111.9 0.0 2.1 1 1 1 2 2 2 1 Tyrosine phosphatase family Y_phosphatase2 PF03162.13 CCF33709.1 - 1.3e-05 24.9 0.0 2.4e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 CCF33709.1 - 0.0017 18.2 0.0 0.94 9.3 0.0 2.3 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 CCF33709.1 - 0.0028 17.3 0.0 0.0039 16.8 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Myotub-related PF06602.14 CCF33709.1 - 0.028 13.3 0.0 0.041 12.8 0.0 1.2 1 0 0 1 1 1 0 Myotubularin-like phosphatase domain MFS_1 PF07690.16 CCF33710.1 - 5.7e-47 160.3 37.3 5.7e-47 160.3 37.3 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF33710.1 - 9e-11 41.3 20.9 1.4e-10 40.7 20.9 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_4 PF06779.14 CCF33710.1 - 1.3e-07 31.3 4.7 1.3e-07 31.3 4.7 2.4 2 1 1 3 3 3 1 Uncharacterised MFS-type transporter YbfB OATP PF03137.20 CCF33710.1 - 0.00029 19.3 6.5 0.00029 19.3 6.5 3.4 3 1 1 4 4 4 1 Organic Anion Transporter Polypeptide (OATP) family MFS_3 PF05977.13 CCF33710.1 - 0.0012 17.4 2.2 0.0019 16.7 2.2 1.4 1 0 0 1 1 1 1 Transmembrane secretion effector p450 PF00067.22 CCF33711.1 - 1.2e-51 175.9 0.0 1.7e-51 175.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Chitin_synth_1 PF01644.17 CCF33712.1 - 2.6e-76 255.1 0.1 4.6e-76 254.3 0.1 1.4 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 CCF33712.1 - 1.7e-27 95.1 0.1 4e-27 94.0 0.1 1.7 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 CCF33712.1 - 2.1e-21 76.2 4.1 5.3e-19 68.2 0.0 2.2 2 0 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 CCF33712.1 - 3.4e-08 33.6 0.3 3.4e-08 33.6 0.3 2.2 3 1 0 3 3 3 1 Glycosyl transferase family group 2 ABC_tran PF00005.27 CCF33713.1 - 1.1e-22 81.0 0.0 1e-09 39.0 0.0 3.7 2 2 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 CCF33713.1 - 1.2e-08 35.1 0.5 0.02 14.7 0.3 3.6 4 0 0 4 4 3 3 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 CCF33713.1 - 1.5e-07 31.5 0.0 0.00059 20.0 0.1 2.4 2 0 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_23 PF13476.6 CCF33713.1 - 6.2e-05 23.6 0.1 0.32 11.4 0.1 2.2 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 CCF33713.1 - 0.00016 21.9 0.1 1.6 9.0 0.0 3.1 4 0 0 4 4 4 2 AAA domain AAA_29 PF13555.6 CCF33713.1 - 0.0004 20.1 0.0 0.58 9.9 0.0 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_33 PF13671.6 CCF33713.1 - 0.0035 17.5 0.0 1.4 9.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 CCF33713.1 - 0.0092 15.7 0.0 3.6 7.3 0.0 2.2 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 CCF33713.1 - 0.016 15.7 0.1 5.9 7.5 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 CCF33713.1 - 0.04 14.3 0.8 4.3 7.7 0.0 2.7 2 2 0 2 2 2 0 AAA ATPase domain Ploopntkinase1 PF18748.1 CCF33713.1 - 0.042 13.4 0.0 0.074 12.6 0.0 1.3 1 0 0 1 1 1 0 P-loop Nucleotide Kinase1 AAA_14 PF13173.6 CCF33713.1 - 0.045 13.8 0.0 2.3 8.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 CCF33713.1 - 0.052 13.9 0.0 2.4 8.6 0.0 2.4 2 0 0 2 2 2 0 RNA helicase PduV-EutP PF10662.9 CCF33713.1 - 0.061 13.1 0.0 0.51 10.1 0.0 2.0 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA PF00004.29 CCF33713.1 - 0.065 13.7 0.1 1.6 9.1 0.0 2.9 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 CCF33713.1 - 0.11 12.7 0.0 27 5.0 0.0 2.6 2 0 0 2 2 2 0 AAA domain SRPRB PF09439.10 CCF33713.1 - 0.12 11.8 0.0 3.4 7.1 0.0 2.1 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit ATPase_2 PF01637.18 CCF33713.1 - 0.19 11.6 0.0 19 5.0 0.0 2.3 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea FtsK_SpoIIIE PF01580.18 CCF33713.1 - 0.2 10.9 0.0 3 7.1 0.0 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family cobW PF02492.19 CCF33713.1 - 0.23 11.1 0.0 5.3 6.6 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain TniB PF05621.11 CCF33713.1 - 0.23 10.9 0.0 20 4.5 0.0 2.2 2 0 0 2 2 2 0 Bacterial TniB protein ATP_bind_1 PF03029.17 CCF33713.1 - 0.29 10.9 0.0 3 7.5 0.0 2.0 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein DUF918 PF06033.11 CCF33714.1 - 0.026 14.5 0.0 0.033 14.2 0.0 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF918) p450 PF00067.22 CCF33715.1 - 9.6e-37 126.8 0.0 1.2e-36 126.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 CCF33716.1 - 1.5e-34 119.5 0.0 1.1e-30 106.9 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 Alkyl_sulf_dimr PF14863.6 CCF33716.1 - 0.082 13.4 0.0 0.14 12.6 0.0 1.3 1 0 0 1 1 1 0 Alkyl sulfatase dimerisation p450 PF00067.22 CCF33717.1 - 3.6e-37 128.2 0.1 3.5e-24 85.4 0.0 2.3 2 1 0 2 2 2 2 Cytochrome P450 MBOAT_2 PF13813.6 CCF33717.1 - 1.8e-22 79.4 2.1 5e-22 78.0 2.1 1.8 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family DUF4418 PF14387.6 CCF33717.1 - 0.064 13.5 0.4 0.16 12.2 0.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4418) ERG4_ERG24 PF01222.17 CCF33718.1 - 7.5e-91 305.0 9.6 8.7e-91 304.8 9.6 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 CCF33718.1 - 3.8e-06 26.6 1.2 9.6e-06 25.3 0.4 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF1295) ICMT PF04140.14 CCF33718.1 - 0.00081 19.8 0.1 0.0035 17.7 0.0 2.1 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family adh_short PF00106.25 CCF33719.1 - 3.6e-24 85.3 0.0 3.5e-19 69.1 0.0 2.1 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCF33719.1 - 4.9e-14 52.4 0.0 6.9e-12 45.4 0.0 2.1 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF33719.1 - 8.8e-08 32.3 0.0 1.4e-07 31.6 0.0 1.2 1 0 0 1 1 1 1 KR domain Rhomboid_SP PF12595.8 CCF33719.1 - 0.0015 17.9 0.0 0.0029 17.0 0.0 1.4 1 0 0 1 1 1 1 Rhomboid serine protease Epimerase PF01370.21 CCF33719.1 - 0.021 14.3 0.0 0.047 13.2 0.0 1.5 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 CCF33719.1 - 0.087 11.9 0.0 0.12 11.5 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein MAPEG PF01124.18 CCF33720.1 - 4.4e-18 65.4 0.4 4.7e-18 65.3 0.4 1.1 1 0 0 1 1 1 1 MAPEG family Glyoxalase PF00903.25 CCF33721.1 - 2.1e-08 34.4 0.0 2.9e-08 33.9 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily AAA PF00004.29 CCF33722.1 - 7.2e-17 62.1 0.0 1.2e-16 61.3 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CCF33722.1 - 0.0013 19.0 0.1 0.01 16.1 0.0 2.2 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.14 CCF33722.1 - 0.0015 18.5 0.0 0.0037 17.3 0.0 1.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CCF33722.1 - 0.0035 17.7 0.1 0.011 16.1 0.1 1.8 1 1 0 1 1 1 1 AAA ATPase domain Zot PF05707.12 CCF33722.1 - 0.0055 16.4 0.0 0.055 13.1 0.0 2.2 2 0 0 2 2 2 1 Zonular occludens toxin (Zot) AAA_2 PF07724.14 CCF33722.1 - 0.0097 16.0 0.0 0.021 14.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_11 PF13086.6 CCF33722.1 - 0.049 13.4 1.9 0.3 10.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 CCF33722.1 - 0.12 12.9 0.3 0.54 10.8 0.0 2.3 2 1 0 2 2 2 0 AAA domain T2SSE PF00437.20 CCF33722.1 - 0.15 11.1 0.0 0.27 10.3 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein BTB PF00651.31 CCF33723.1 - 0.029 14.6 0.0 0.093 13.0 0.0 1.7 2 0 0 2 2 2 0 BTB/POZ domain PGA2 PF07543.12 CCF33724.1 - 0.1 12.6 2.7 0.16 11.9 2.7 1.4 1 0 0 1 1 1 0 Protein trafficking PGA2 Methyltransf_23 PF13489.6 CCF33727.1 - 4.3e-11 42.9 0.0 6.3e-11 42.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF33727.1 - 2e-07 31.5 0.0 1.2e-06 29.1 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF33727.1 - 2.5e-06 28.1 0.0 0.00016 22.3 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF33727.1 - 0.0024 18.6 0.0 0.0062 17.3 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF33727.1 - 0.051 13.4 0.0 0.076 12.8 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Ubie_methyltran PF01209.18 CCF33727.1 - 0.17 11.2 0.0 0.23 10.8 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Cytomega_UL84 PF06284.11 CCF33727.1 - 1.5 7.2 3.1 2.1 6.7 3.1 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein Ldh_2 PF02615.14 CCF33728.1 - 4e-104 348.4 0.4 4.5e-104 348.2 0.4 1.0 1 0 0 1 1 1 1 Malate/L-lactate dehydrogenase Pkinase PF00069.25 CCF33729.1 - 9.5e-60 202.2 0.8 1.3e-59 201.7 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF33729.1 - 3.6e-35 121.5 0.0 7.3e-35 120.5 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.22 CCF33729.1 - 9.8e-20 70.2 31.5 4.7e-12 45.6 11.4 2.4 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) HR1 PF02185.16 CCF33729.1 - 3.9e-19 68.5 19.9 1.3e-12 47.6 4.4 3.2 3 0 0 3 3 3 2 Hr1 repeat Pkinase_C PF00433.24 CCF33729.1 - 2.4e-14 53.8 1.0 1.2e-13 51.6 1.0 2.3 1 0 0 1 1 1 1 Protein kinase C terminal domain C2 PF00168.30 CCF33729.1 - 0.00071 19.8 0.0 0.0014 18.9 0.0 1.4 1 0 0 1 1 1 1 C2 domain PAT1 PF09770.9 CCF33729.1 - 0.016 13.5 16.2 0.028 12.7 16.2 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Presenilin PF01080.17 CCF33729.1 - 0.25 10.1 2.5 0.4 9.4 2.5 1.3 1 0 0 1 1 1 0 Presenilin Haspin_kinase PF12330.8 CCF33729.1 - 1.4 7.8 4.5 4.1 6.3 4.5 1.8 1 1 0 1 1 1 0 Haspin like kinase domain zf-RING_9 PF13901.6 CCF33729.1 - 2.2 8.2 22.6 2.3 8.1 7.5 2.6 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon DUF3597 PF12200.8 CCF33730.1 - 0.033 14.7 1.0 0.04 14.5 1.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3597) PaaX_C PF08223.11 CCF33730.1 - 0.053 13.8 0.3 0.094 13.0 0.2 1.4 1 1 0 1 1 1 0 PaaX-like protein C-terminal domain Casc1_N PF15927.5 CCF33730.1 - 0.16 11.6 2.9 0.18 11.5 2.9 1.1 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 N-terminus Sugar_tr PF00083.24 CCF33731.1 - 1.3e-74 251.7 23.6 1.5e-74 251.5 23.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF33731.1 - 9.4e-20 70.8 28.7 9.4e-20 70.8 28.7 2.1 1 1 0 2 2 2 1 Major Facilitator Superfamily Fungal_trans PF04082.18 CCF33732.1 - 8.9e-10 38.0 0.2 8.9e-10 38.0 0.2 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF33732.1 - 0.00044 20.3 8.2 0.00082 19.5 8.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ANTH PF07651.16 CCF33733.1 - 1.1e-81 273.8 0.0 1.1e-81 273.8 0.0 2.7 3 0 0 3 3 3 1 ANTH domain I_LWEQ PF01608.17 CCF33733.1 - 2e-55 187.3 9.6 2e-55 187.3 9.6 6.4 3 2 5 8 8 8 2 I/LWEQ domain Ribosomal_L21e PF01157.18 CCF33734.1 - 4e-48 161.4 3.1 6.5e-48 160.8 3.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L21e DUF5486 PF17588.2 CCF33734.1 - 0.033 14.1 0.6 0.99 9.3 0.0 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5486) S4 PF01479.25 CCF33735.1 - 2.4e-12 46.4 0.9 2.4e-12 46.4 0.9 2.7 3 0 0 3 3 3 1 S4 domain Ribosomal_S4 PF00163.19 CCF33735.1 - 8.9e-06 26.5 0.1 1.7e-05 25.6 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain Uds1 PF15456.6 CCF33735.1 - 0.094 12.9 0.4 3 8.0 0.0 2.2 2 0 0 2 2 2 0 Up-regulated During Septation tRNA-synt_2 PF00152.20 CCF33737.1 - 1.5e-62 211.5 0.0 2.6e-62 210.7 0.0 1.4 1 1 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 CCF33737.1 - 1.7e-08 34.3 0.0 3e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 CCF33737.1 - 5.3e-06 26.1 0.3 0.0092 15.5 0.0 2.6 3 0 0 3 3 3 2 tRNA synthetases class II core domain (F) HMG-CoA_red PF00368.18 CCF33738.1 - 3.4e-136 454.1 4.2 4.4e-136 453.7 4.2 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase HPIH PF13323.6 CCF33738.1 - 4.4e-44 150.1 3.5 8e-44 149.2 3.5 1.5 1 0 0 1 1 1 1 N-terminal domain with HPIH motif Sterol-sensing PF12349.8 CCF33738.1 - 2.7e-14 53.3 1.8 8.2e-14 51.7 1.8 1.8 1 0 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.18 CCF33738.1 - 4.8e-05 21.7 0.7 4.8e-05 21.7 0.7 1.4 2 0 0 2 2 2 1 Patched family KR PF08659.10 CCF33739.1 - 2.8e-64 216.4 0.3 2.8e-64 216.4 0.3 1.6 2 0 0 2 2 2 1 KR domain ADH_zinc_N PF00107.26 CCF33739.1 - 1.2e-17 64.1 0.4 6.1e-17 61.8 0.3 2.3 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCF33739.1 - 7.2e-16 59.5 0.1 2.3e-15 57.8 0.1 1.9 2 0 0 2 2 1 1 Zinc-binding dehydrogenase adh_short PF00106.25 CCF33739.1 - 1.5e-15 57.2 2.2 4.4e-14 52.4 0.1 2.9 3 0 0 3 3 3 1 short chain dehydrogenase PP-binding PF00550.25 CCF33739.1 - 4.2e-09 36.6 0.1 9.8e-09 35.4 0.1 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site adh_short_C2 PF13561.6 CCF33739.1 - 4.8e-08 32.8 0.0 1.2e-07 31.5 0.0 1.6 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Sacchrp_dh_NADP PF03435.18 CCF33739.1 - 4e-05 23.9 0.3 0.0003 21.0 0.0 2.2 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.21 CCF33739.1 - 0.01 15.3 0.0 0.02 14.3 0.0 1.6 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 CCF33739.1 - 0.033 13.3 0.0 0.054 12.6 0.0 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 CCF33739.1 - 0.04 13.3 0.0 0.065 12.6 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 CCF33739.1 - 0.084 11.9 0.0 0.18 10.7 0.0 1.5 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Shikimate_DH PF01488.20 CCF33739.1 - 0.14 12.2 0.0 0.83 9.7 0.0 2.1 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase ThiF PF00899.21 CCF33739.1 - 0.33 10.3 1.1 1.6 8.0 0.1 2.1 2 0 0 2 2 2 0 ThiF family PrpF PF04303.13 CCF33741.1 - 2e-89 300.2 0.0 2.6e-89 299.8 0.0 1.1 1 0 0 1 1 1 1 PrpF protein PBP PF01161.20 CCF33742.1 - 9.4e-16 58.3 0.0 1.3e-15 57.9 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein Arginosuc_synth PF00764.19 CCF33744.1 - 6.1e-151 503.1 0.0 7e-151 502.9 0.0 1.0 1 0 0 1 1 1 1 Arginosuccinate synthase QueC PF06508.13 CCF33744.1 - 0.1 12.1 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC Ribonuclease PF00545.20 CCF33745.1 - 6.8e-09 36.4 0.0 1e-08 35.8 0.0 1.2 1 0 0 1 1 1 1 ribonuclease DUF3632 PF12311.8 CCF33746.1 - 1e-37 130.2 5.6 1.4e-37 129.8 5.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3632) ABC_tran PF00005.27 CCF33747.1 - 1.3e-51 174.7 0.0 4.8e-30 104.9 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 CCF33747.1 - 2.7e-26 92.8 25.2 3.9e-17 62.8 12.2 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 CCF33747.1 - 3.5e-11 43.0 0.1 0.0001 21.8 0.1 4.2 3 1 1 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CCF33747.1 - 2.2e-09 36.9 0.3 0.0036 17.0 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.6 CCF33747.1 - 1.2e-08 35.1 0.8 0.031 14.1 0.1 3.4 2 1 1 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 CCF33747.1 - 1.7e-08 34.8 0.6 0.012 15.9 0.2 3.3 2 1 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 CCF33747.1 - 7e-07 29.3 0.0 0.041 14.0 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CCF33747.1 - 8.3e-07 29.1 0.0 0.02 14.8 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_30 PF13604.6 CCF33747.1 - 7.9e-06 25.7 0.4 0.12 12.0 0.0 4.0 3 1 0 3 3 3 1 AAA domain AAA_33 PF13671.6 CCF33747.1 - 1.1e-05 25.6 0.0 0.05 13.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_23 PF13476.6 CCF33747.1 - 1.1e-05 26.0 0.1 0.21 12.1 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 CCF33747.1 - 1.8e-05 25.2 2.6 0.13 12.6 0.4 2.9 2 1 0 2 2 2 2 AAA ATPase domain cobW PF02492.19 CCF33747.1 - 8.1e-05 22.3 0.6 0.024 14.2 0.3 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain Dynamin_N PF00350.23 CCF33747.1 - 0.00022 21.3 0.0 0.15 12.1 0.0 2.6 2 0 0 2 2 2 1 Dynamin family DUF87 PF01935.17 CCF33747.1 - 0.00026 21.2 1.4 0.0044 17.2 0.1 2.5 3 0 0 3 3 2 1 Helicase HerA, central domain AAA_18 PF13238.6 CCF33747.1 - 0.00034 21.1 0.0 1.4 9.5 0.0 3.0 3 0 0 3 3 2 2 AAA domain FtsK_SpoIIIE PF01580.18 CCF33747.1 - 0.00046 19.6 0.1 0.21 10.9 0.0 2.3 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_15 PF13175.6 CCF33747.1 - 0.00081 19.2 0.1 0.81 9.3 0.0 2.2 2 0 0 2 2 2 2 AAA ATPase domain T2SSE PF00437.20 CCF33747.1 - 0.0011 18.1 0.1 0.69 8.9 0.0 2.4 2 0 0 2 2 2 1 Type II/IV secretion system protein IstB_IS21 PF01695.17 CCF33747.1 - 0.0018 18.1 1.2 11 5.8 0.0 4.1 4 0 0 4 4 4 0 IstB-like ATP binding protein AAA_7 PF12775.7 CCF33747.1 - 0.0027 17.2 0.1 1.5 8.3 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region GTP_EFTU PF00009.27 CCF33747.1 - 0.0028 17.2 0.1 0.5 9.9 0.0 2.4 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_25 PF13481.6 CCF33747.1 - 0.0029 17.2 2.4 0.28 10.7 0.0 3.0 3 0 0 3 3 3 1 AAA domain NACHT PF05729.12 CCF33747.1 - 0.0038 17.2 2.2 0.8 9.6 0.2 3.0 3 0 0 3 3 3 1 NACHT domain AAA_5 PF07728.14 CCF33747.1 - 0.0071 16.3 0.1 0.77 9.8 0.0 2.7 3 0 0 3 3 2 1 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.12 CCF33747.1 - 0.0082 15.4 2.9 0.91 8.8 0.0 3.0 4 0 0 4 4 2 1 Zeta toxin NB-ARC PF00931.22 CCF33747.1 - 0.0082 15.3 0.1 5.3 6.1 0.0 2.6 2 0 0 2 2 2 0 NB-ARC domain Roc PF08477.13 CCF33747.1 - 0.0091 16.2 0.0 5.7 7.2 0.0 3.1 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase DUF815 PF05673.13 CCF33747.1 - 0.0096 15.1 0.0 2.7 7.1 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF815) RNA_helicase PF00910.22 CCF33747.1 - 0.019 15.4 0.1 18 5.8 0.0 3.1 3 0 0 3 3 3 0 RNA helicase AAA PF00004.29 CCF33747.1 - 0.023 15.1 0.0 2 8.9 0.0 2.8 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) ATP_bind_1 PF03029.17 CCF33747.1 - 0.032 14.0 0.0 2.9 7.6 0.0 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein SbcCD_C PF13558.6 CCF33747.1 - 0.036 14.3 0.2 4.1 7.7 0.0 3.1 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit DEAD PF00270.29 CCF33747.1 - 0.046 13.5 0.4 2.5 7.9 0.0 2.8 3 0 0 3 3 2 0 DEAD/DEAH box helicase Septin PF00735.18 CCF33747.1 - 0.046 13.0 0.0 4.2 6.6 0.0 2.3 2 0 0 2 2 2 0 Septin Adeno_IVa2 PF02456.15 CCF33747.1 - 0.05 12.4 0.0 3.1 6.5 0.1 2.7 3 0 0 3 3 3 0 Adenovirus IVa2 protein Rad17 PF03215.15 CCF33747.1 - 0.058 13.3 0.2 2.7 7.9 0.0 2.4 2 0 0 2 2 2 0 Rad17 P-loop domain ATPase_2 PF01637.18 CCF33747.1 - 0.07 13.0 0.0 2.6 7.9 0.0 2.4 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_24 PF13479.6 CCF33747.1 - 0.075 12.7 1.0 5.6 6.6 0.1 2.4 2 1 0 2 2 2 0 AAA domain KAP_NTPase PF07693.14 CCF33747.1 - 0.083 12.1 0.0 13 4.9 0.0 2.2 2 0 0 2 2 2 0 KAP family P-loop domain PduV-EutP PF10662.9 CCF33747.1 - 0.093 12.5 0.1 3 7.6 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation TsaE PF02367.17 CCF33747.1 - 0.096 12.7 0.0 4.7 7.2 0.0 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 CCF33747.1 - 0.1 12.6 0.0 7.6 6.6 0.0 2.9 3 0 0 3 3 3 0 AAA domain NTPase_1 PF03266.15 CCF33747.1 - 0.11 12.4 1.2 8.4 6.3 0.1 2.6 2 0 0 2 2 2 0 NTPase G-alpha PF00503.20 CCF33747.1 - 0.13 11.4 0.0 5.6 6.0 0.0 2.2 2 0 0 2 2 2 0 G-protein alpha subunit Viral_helicase1 PF01443.18 CCF33747.1 - 0.14 11.8 0.1 21 4.8 0.0 2.5 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_28 PF13521.6 CCF33747.1 - 0.2 11.9 1.1 11 6.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain DUF5325 PF17259.2 CCF33747.1 - 2.5 8.0 5.2 1.3 9.0 1.6 2.5 2 0 0 2 2 1 0 Family of unknown function (DUF5325) Asn_synthase PF00733.21 CCF33748.1 - 2.8e-67 227.9 0.3 3.9e-67 227.4 0.3 1.1 1 0 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.6 CCF33748.1 - 1.4e-33 115.4 0.0 3.2e-33 114.3 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 CCF33748.1 - 1.4e-27 96.6 0.0 1.6e-26 93.1 0.0 2.5 2 0 0 2 2 2 1 Glutamine amidotransferase domain DUF3700 PF12481.8 CCF33748.1 - 0.00068 19.2 0.0 0.0021 17.6 0.0 1.7 2 0 0 2 2 2 1 Aluminium induced protein tRNA_Me_trans PF03054.16 CCF33748.1 - 0.0068 15.2 0.0 0.01 14.6 0.0 1.2 1 0 0 1 1 1 1 tRNA methyl transferase AIRC PF00731.20 CCF33748.1 - 0.19 11.3 0.1 17 4.9 0.0 2.7 2 0 0 2 2 2 0 AIR carboxylase adh_short PF00106.25 CCF33749.1 - 7.8e-22 77.7 0.0 7.4e-14 51.7 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCF33749.1 - 1.8e-13 50.6 0.0 1.2e-06 28.2 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.6 CCF33749.1 - 0.0002 21.3 0.8 0.00027 20.9 0.7 1.4 1 1 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 CCF33749.1 - 0.007 16.3 0.1 0.013 15.5 0.1 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF33749.1 - 0.082 12.4 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family NmrA PF05368.13 CCF33749.1 - 0.18 11.3 0.4 1.4 8.4 0.3 2.1 2 0 0 2 2 2 0 NmrA-like family BBE PF08031.12 CCF33750.1 - 4.6e-07 29.8 0.0 8.2e-07 29.0 0.0 1.5 1 0 0 1 1 1 1 Berberine and berberine like Cytokin-bind PF09265.10 CCF33750.1 - 0.21 11.0 0.0 0.25 10.7 0.0 1.1 1 0 0 1 1 1 0 Cytokinin dehydrogenase 1, FAD and cytokinin binding p450 PF00067.22 CCF33751.1 - 7.9e-54 183.1 0.0 1.5e-53 182.2 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 CCF33752.1 - 8.2e-06 24.8 0.0 1e-05 24.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Dsl1_C PF11989.8 CCF33753.1 - 0.0043 16.8 0.0 0.009 15.7 0.0 1.4 1 0 0 1 1 1 1 Retrograde transport protein Dsl1 C terminal Nop14 PF04147.12 CCF33753.1 - 0.21 9.8 8.6 0.29 9.3 8.6 1.1 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 CCF33753.1 - 0.33 9.2 3.9 0.51 8.6 3.9 1.1 1 0 0 1 1 1 0 CDC45-like protein Cwf_Cwc_15 PF04889.12 CCF33753.1 - 0.54 10.0 9.6 0.88 9.3 9.6 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein p450 PF00067.22 CCF33754.1 - 0.0059 15.4 0.0 0.0064 15.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DSBA PF01323.20 CCF33755.1 - 2.2e-34 118.9 0.0 2.6e-34 118.7 0.0 1.0 1 0 0 1 1 1 1 DSBA-like thioredoxin domain Thioredoxin_5 PF13743.6 CCF33755.1 - 0.0058 16.3 0.0 0.0085 15.8 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_4 PF13462.6 CCF33755.1 - 0.0085 16.3 0.0 0.015 15.5 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin DUF465 PF04325.13 CCF33755.1 - 0.081 13.0 1.4 0.12 12.5 0.5 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF465) p450 PF00067.22 CCF33756.1 - 3.3e-49 167.9 0.0 7.3e-49 166.8 0.0 1.5 1 1 0 1 1 1 1 Cytochrome P450 TFIIA PF03153.13 CCF33757.1 - 0.064 13.2 7.0 0.079 12.9 7.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FancD2 PF14631.6 CCF33757.1 - 4.1 4.7 6.2 4.9 4.4 6.2 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease RR_TM4-6 PF06459.12 CCF33757.1 - 4.9 6.9 11.2 7 6.4 11.2 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF1899 PF08953.11 CCF33758.1 - 8.9e-35 118.4 0.2 2.4e-34 117.0 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF1899) WD40_4 PF16300.5 CCF33758.1 - 5.4e-19 67.8 0.1 1.1e-18 66.9 0.1 1.6 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.32 CCF33758.1 - 7.3e-17 61.5 6.9 1.7e-05 25.5 0.9 4.4 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF33758.1 - 6e-09 36.1 0.1 0.0019 18.5 0.0 4.0 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CCF33758.1 - 0.0061 15.3 0.3 0.51 8.9 0.1 2.2 1 1 1 2 2 2 2 Nucleoporin Nup120/160 DUF16 PF01519.16 CCF33758.1 - 0.063 13.8 1.8 0.14 12.7 1.8 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF16 SlyX PF04102.12 CCF33758.1 - 0.82 10.3 7.7 0.47 11.1 3.7 2.3 2 0 0 2 2 2 0 SlyX DivIC PF04977.15 CCF33758.1 - 1.7 8.5 4.3 3.2 7.6 3.8 1.6 1 1 0 1 1 1 0 Septum formation initiator Anillin PF08174.11 CCF33759.1 - 9.2e-16 58.6 0.0 2.7e-15 57.1 0.0 1.8 1 0 0 1 1 1 1 Cell division protein anillin PH PF00169.29 CCF33759.1 - 8.2e-09 35.9 0.0 3.1e-08 34.1 0.0 2.1 1 1 0 1 1 1 1 PH domain PH_11 PF15413.6 CCF33759.1 - 0.029 14.8 2.2 0.11 12.9 0.0 2.7 3 0 0 3 3 3 0 Pleckstrin homology domain AP-5_subunit_s1 PF15001.6 CCF33759.1 - 0.18 11.7 0.6 0.5 10.3 0.6 1.7 1 0 0 1 1 1 0 AP-5 complex subunit sigma-1 Importin_rep_4 PF18808.1 CCF33760.1 - 3.2e-32 110.7 9.3 1.1e-31 109.0 1.9 4.4 4 1 1 5 5 4 1 Importin repeat HEAT_EZ PF13513.6 CCF33760.1 - 4e-23 81.5 12.7 5.6e-11 42.7 0.3 9.5 8 1 2 10 10 10 3 HEAT-like repeat Importin_rep_5 PF18816.1 CCF33760.1 - 6e-21 74.5 6.0 1.1e-20 73.6 1.5 3.6 4 0 0 4 4 3 1 Importin repeat HEAT PF02985.22 CCF33760.1 - 1.8e-19 68.1 19.8 0.0039 17.3 0.0 12.5 14 0 0 14 14 12 3 HEAT repeat HEAT_2 PF13646.6 CCF33760.1 - 5.8e-19 68.3 12.1 7.3e-07 29.5 0.1 8.6 4 3 2 7 7 7 4 HEAT repeats Importin_rep_6 PF18829.1 CCF33760.1 - 1.1e-13 51.3 2.7 2e-12 47.2 0.2 3.5 3 0 0 3 3 2 1 Importin repeat 6 Vac14_Fab1_bd PF12755.7 CCF33760.1 - 1.2e-13 51.5 0.4 0.0059 17.2 0.0 8.3 6 2 4 10 10 9 2 Vacuolar 14 Fab1-binding region DUF3385 PF11865.8 CCF33760.1 - 4.2e-10 39.8 0.0 0.05 13.5 0.1 6.5 7 1 1 8 8 7 2 Domain of unknown function (DUF3385) RIX1 PF08167.12 CCF33760.1 - 1.2e-08 35.0 0.0 0.00014 21.6 0.0 4.9 3 1 1 4 4 4 2 rRNA processing/ribosome biogenesis Cnd1 PF12717.7 CCF33760.1 - 1.2e-08 35.2 0.6 0.12 12.4 0.0 6.2 6 2 1 7 7 7 1 non-SMC mitotic condensation complex subunit 1 DRIM PF07539.12 CCF33760.1 - 7.6e-08 31.1 6.6 0.00027 19.4 0.7 4.3 2 2 1 3 3 3 2 Down-regulated in metastasis CLASP_N PF12348.8 CCF33760.1 - 3.8e-07 29.9 0.2 0.0021 17.7 0.1 5.2 4 1 1 5 5 5 1 CLASP N terminal MMS19_C PF12460.8 CCF33760.1 - 8.2e-07 28.5 7.4 2.9e-06 26.7 0.5 4.7 5 1 0 6 6 6 1 RNAPII transcription regulator C-terminal DUF3535 PF12054.8 CCF33760.1 - 0.00044 19.6 0.9 0.0013 18.1 0.5 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF3535) UNC45-central PF11701.8 CCF33760.1 - 0.00054 20.0 4.4 0.73 9.8 0.4 4.6 4 0 0 4 4 4 1 Myosin-binding striated muscle assembly central DUF4042 PF13251.6 CCF33760.1 - 0.0011 18.6 0.1 8.2 6.1 0.0 5.0 5 0 0 5 5 5 0 Domain of unknown function (DUF4042) Arm PF00514.23 CCF33760.1 - 0.0015 18.5 9.0 4 7.6 0.0 5.8 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat RTP1_C1 PF10363.9 CCF33760.1 - 0.0019 18.3 1.9 0.25 11.6 0.4 4.8 4 2 2 6 6 6 1 Required for nuclear transport of RNA pol II C-terminus 1 CAS_CSE1 PF03378.15 CCF33760.1 - 0.014 13.9 0.2 5.2 5.4 0.1 3.4 1 1 3 4 4 4 0 CAS/CSE protein, C-terminus Cohesin_HEAT PF12765.7 CCF33760.1 - 0.017 15.4 0.7 2 8.8 0.0 3.5 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion IBN_N PF03810.19 CCF33760.1 - 0.028 14.3 4.3 0.035 14.0 0.1 3.5 4 1 1 5 5 3 0 Importin-beta N-terminal domain Cnd3 PF12719.7 CCF33760.1 - 0.038 13.2 0.0 1.9 7.6 0.0 3.2 2 1 0 2 2 2 0 Nuclear condensing complex subunits, C-term domain DNA_alkylation PF08713.11 CCF33760.1 - 0.041 13.6 0.0 0.49 10.1 0.0 2.7 2 1 1 3 3 2 0 DNA alkylation repair enzyme Xpo1 PF08389.12 CCF33760.1 - 0.051 13.6 0.0 2 8.5 0.0 3.2 2 0 0 2 2 2 0 Exportin 1-like protein Dopey_N PF04118.14 CCF33760.1 - 0.051 12.7 3.0 4.5 6.3 0.1 3.3 3 2 1 4 4 4 0 Dopey, N-terminal RB_A PF01858.17 CCF33760.1 - 0.13 12.1 1.1 7 6.4 0.4 2.8 2 0 0 2 2 2 0 Retinoblastoma-associated protein A domain Telomere_reg-2 PF10193.9 CCF33760.1 - 0.13 12.7 6.9 0.32 11.5 1.9 3.7 3 1 1 4 4 4 0 Telomere length regulation protein DUF445 PF04286.12 CCF33760.1 - 0.4 10.5 3.3 3.2 7.5 0.3 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF445) V-ATPase_H_N PF03224.14 CCF33760.1 - 0.95 8.7 6.7 0.58 9.4 0.5 3.2 2 2 0 3 3 3 0 V-ATPase subunit H F-box-like PF12937.7 CCF33761.1 - 0.00059 19.7 0.0 0.0017 18.2 0.0 1.8 1 0 0 1 1 1 1 F-box-like CFEM PF05730.11 CCF33762.1 - 1.2e-09 38.1 8.5 2.9e-09 36.9 8.5 1.6 1 0 0 1 1 1 1 CFEM domain DUF5585 PF17823.1 CCF33762.1 - 0.3 10.0 28.8 0.33 9.9 28.8 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5585) Adenylsucc_synt PF00709.21 CCF33763.1 - 4.8e-06 25.7 0.4 6e-06 25.4 0.4 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase Adenylsucc_synt PF00709.21 CCF33764.1 - 7.4e-44 150.3 0.0 8.1e-44 150.2 0.0 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase zf-DNA_Pol PF08996.10 CCF33765.1 - 2.5e-32 112.2 0.1 2.7e-32 112.0 0.1 1.0 1 0 0 1 1 1 1 DNA Polymerase alpha zinc finger CRISPR_Cas9_WED PF18061.1 CCF33765.1 - 0.042 13.9 0.0 0.047 13.8 0.0 1.2 1 0 0 1 1 1 0 CRISPR-Cas9 WED domain RF3_C PF16658.5 CCF33765.1 - 0.11 12.4 0.1 0.14 12.0 0.1 1.1 1 0 0 1 1 1 0 Class II release factor RF3, C-terminal domain Cor1 PF04803.12 CCF33765.1 - 0.19 11.9 0.0 0.25 11.6 0.0 1.1 1 0 0 1 1 1 0 Cor1/Xlr/Xmr conserved region MIF4G PF02854.19 CCF33766.1 - 5.1e-51 173.3 0.0 9.4e-51 172.4 0.0 1.4 1 0 0 1 1 1 1 MIF4G domain eIF_4G1 PF12152.8 CCF33766.1 - 5.9e-23 80.8 1.1 1.6e-22 79.4 1.1 1.8 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 4G1 DUF4148 PF13663.6 CCF33766.1 - 0.012 15.8 0.2 1.4 9.1 0.1 3.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4148) Methyltransf_2 PF00891.18 CCF33767.1 - 1.7e-23 83.1 0.0 2e-23 82.8 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Trp_DMAT PF11991.8 CCF33768.1 - 4.3e-70 236.9 0.0 4.8e-70 236.8 0.0 1.0 1 0 0 1 1 1 1 Tryptophan dimethylallyltransferase Lactamase_B PF00753.27 CCF33769.1 - 1.1e-10 41.9 6.0 2.2e-10 40.9 6.0 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CCF33769.1 - 0.0003 20.4 0.1 0.00072 19.1 0.1 1.6 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Abhydrolase_3 PF07859.13 CCF33770.1 - 8.4e-18 65.0 0.2 1.4e-16 61.0 0.2 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CCF33770.1 - 8.1e-09 35.3 0.0 8.7e-05 22.1 0.0 2.5 2 0 0 2 2 2 2 Prolyl oligopeptidase family Methyltransf_23 PF13489.6 CCF33770.1 - 6.8e-08 32.5 0.0 1.3e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain COesterase PF00135.28 CCF33770.1 - 2.5e-07 30.0 0.0 3.9e-07 29.3 0.0 1.2 1 0 0 1 1 1 1 Carboxylesterase family Methyltransf_12 PF08242.12 CCF33770.1 - 1.4e-06 28.9 0.0 6.2e-06 26.9 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Peptidase_S15 PF02129.18 CCF33770.1 - 4.1e-06 26.6 0.0 2.5e-05 24.0 0.0 2.2 2 1 0 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) DLH PF01738.18 CCF33770.1 - 9.8e-05 22.0 0.0 0.041 13.4 0.0 2.2 2 0 0 2 2 2 2 Dienelactone hydrolase family Methyltransf_11 PF08241.12 CCF33770.1 - 0.00022 21.8 0.0 0.00053 20.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Chlorophyllase2 PF12740.7 CCF33770.1 - 0.0008 18.4 0.0 0.0012 17.8 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme Methyltransf_25 PF13649.6 CCF33770.1 - 0.0076 16.9 0.0 0.021 15.5 0.0 1.8 2 0 0 2 2 1 1 Methyltransferase domain Esterase PF00756.20 CCF33770.1 - 0.0077 15.9 0.0 0.018 14.7 0.0 1.6 1 0 0 1 1 1 1 Putative esterase Methyltransf_31 PF13847.6 CCF33770.1 - 0.025 14.4 0.0 0.039 13.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Abhydrolase_2 PF02230.16 CCF33770.1 - 0.04 13.7 0.0 11 5.8 0.0 2.3 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Abhydrolase_6 PF12697.7 CCF33770.1 - 0.042 14.4 18.2 0.01 16.4 14.8 1.7 1 1 1 2 2 2 0 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCF33770.1 - 0.071 12.4 0.1 0.41 9.9 0.1 2.1 1 1 0 1 1 1 0 Serine aminopeptidase, S33 Chlorophyllase PF07224.11 CCF33770.1 - 0.084 11.9 0.0 0.14 11.1 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase HET PF06985.11 CCF33771.1 - 5.9e-30 104.5 0.2 8.7e-30 104.0 0.2 1.3 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Mito_carr PF00153.27 CCF33773.1 - 1.3e-43 146.8 8.1 2e-16 59.7 0.2 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Fungal_trans PF04082.18 CCF33774.1 - 1.6e-26 93.0 0.0 7e-25 87.6 0.0 2.4 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF33774.1 - 3e-08 33.6 9.0 5.5e-08 32.8 9.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 CCF33774.1 - 0.00061 18.7 0.0 0.0019 17.1 0.0 1.8 1 0 0 1 1 1 1 Fungal specific transcription factor domain Fungal_trans_2 PF11951.8 CCF33775.1 - 2.5e-36 125.3 0.0 2.8e-36 125.2 0.0 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain FMO-like PF00743.19 CCF33776.1 - 5.3e-44 150.5 0.0 5.8e-25 87.7 0.0 3.3 3 1 0 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 CCF33776.1 - 3.2e-15 56.2 0.0 4.8e-09 35.9 0.0 3.5 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CCF33776.1 - 6.8e-13 48.5 0.0 6.9e-12 45.2 0.0 2.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CCF33776.1 - 3.1e-12 46.8 1.9 1.7e-09 37.9 0.1 4.1 3 2 1 4 4 4 1 FAD-NAD(P)-binding DAO PF01266.24 CCF33776.1 - 1.7e-10 41.1 0.1 3.8e-06 26.7 0.0 3.6 2 1 1 4 4 4 1 FAD dependent oxidoreductase K_oxygenase PF13434.6 CCF33776.1 - 9.6e-10 38.1 0.0 1.8e-07 30.6 0.0 2.7 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 CCF33776.1 - 6.8e-09 35.8 0.0 7.2e-08 32.6 0.0 2.6 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 CCF33776.1 - 2.7e-07 30.1 0.0 0.00027 20.3 0.0 2.3 2 0 0 2 2 2 2 Thi4 family Pyr_redox PF00070.27 CCF33776.1 - 4.8e-06 27.0 0.0 0.0098 16.4 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CCF33776.1 - 7.2e-06 25.0 0.0 0.0096 14.7 0.2 2.5 3 0 0 3 3 3 2 HI0933-like protein Glu_dehyd_C PF16912.5 CCF33776.1 - 0.00011 21.7 0.0 0.21 11.0 0.0 2.3 2 0 0 2 2 2 2 Glucose dehydrogenase C-terminus Amino_oxidase PF01593.24 CCF33776.1 - 0.00049 19.5 0.0 0.008 15.5 0.0 2.4 3 0 0 3 3 3 1 Flavin containing amine oxidoreductase FAD_binding_2 PF00890.24 CCF33776.1 - 0.00067 18.8 0.1 0.23 10.5 0.0 2.6 3 0 0 3 3 3 2 FAD binding domain Lycopene_cycl PF05834.12 CCF33776.1 - 0.003 16.7 0.0 0.88 8.5 0.0 2.1 2 0 0 2 2 2 2 Lycopene cyclase protein FAD_binding_3 PF01494.19 CCF33776.1 - 0.0034 16.7 0.1 0.098 11.9 0.0 2.2 2 0 0 2 2 2 1 FAD binding domain Shikimate_DH PF01488.20 CCF33776.1 - 0.01 15.9 0.0 0.45 10.6 0.0 2.3 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 CCF33776.1 - 0.02 14.3 0.0 1.1 8.5 0.0 2.2 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain MCRA PF06100.11 CCF33776.1 - 0.024 13.5 0.0 0.042 12.6 0.0 1.4 1 0 0 1 1 1 0 MCRA family TrkA_N PF02254.18 CCF33776.1 - 0.057 13.7 0.0 0.28 11.5 0.0 2.0 2 0 0 2 2 2 0 TrkA-N domain NAD_binding_7 PF13241.6 CCF33776.1 - 0.12 12.8 0.1 22 5.6 0.0 2.6 2 1 0 2 2 2 0 Putative NAD(P)-binding FAD_oxidored PF12831.7 CCF33776.1 - 0.16 11.2 0.0 0.36 10.1 0.0 1.5 1 0 0 1 1 1 0 FAD dependent oxidoreductase Peptidase_M41 PF01434.18 CCF33778.1 - 8.3e-69 231.3 0.0 1.4e-68 230.5 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 CCF33778.1 - 1e-42 145.7 0.0 3e-42 144.2 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CCF33778.1 - 4.1e-12 45.7 0.2 1.1e-11 44.3 0.2 1.7 1 0 0 1 1 1 1 AAA+ lid domain FtsH_ext PF06480.15 CCF33778.1 - 3.5e-09 37.0 0.0 7.8e-09 35.9 0.0 1.6 1 0 0 1 1 1 1 FtsH Extracellular AAA_17 PF13207.6 CCF33778.1 - 0.00039 20.8 0.0 0.73 10.3 0.0 3.1 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 CCF33778.1 - 0.0004 20.4 0.1 0.0019 18.2 0.0 2.3 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 CCF33778.1 - 0.0047 16.2 0.1 0.0098 15.1 0.1 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain RuvB_N PF05496.12 CCF33778.1 - 0.0056 16.4 0.0 0.021 14.6 0.0 2.0 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 CCF33778.1 - 0.0068 16.8 0.2 0.34 11.3 0.1 2.8 1 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 CCF33778.1 - 0.0083 16.4 0.2 1.5 9.1 0.1 2.8 2 0 0 2 2 2 1 AAA domain AAA_2 PF07724.14 CCF33778.1 - 0.017 15.2 0.1 0.093 12.8 0.0 2.2 2 1 0 2 2 2 0 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.17 CCF33778.1 - 0.075 12.8 0.0 0.18 11.5 0.0 1.7 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_25 PF13481.6 CCF33778.1 - 0.097 12.2 0.4 0.64 9.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 CCF33778.1 - 0.32 11.6 1.3 2.3 8.8 0.1 2.8 3 1 0 3 3 3 0 AAA domain HAND PF09110.11 CCF33778.1 - 1.4 9.7 10.0 0.12 13.1 3.0 2.3 2 0 0 2 2 2 0 HAND Fungal_trans PF04082.18 CCF33779.1 - 1.7e-26 92.8 0.0 1e-25 90.3 0.0 2.2 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF33779.1 - 1.1e-10 41.4 12.0 2e-10 40.6 12.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Stm1_N PF09598.10 CCF33779.1 - 4.9 8.1 9.8 0.24 12.3 0.8 2.7 2 0 0 2 2 2 0 Stm1 TRI12 PF06609.13 CCF33780.1 - 1.1e-32 113.2 23.1 1.4e-32 112.9 23.1 1.0 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_1 PF07690.16 CCF33780.1 - 0.0001 21.3 51.5 0.00094 18.2 51.5 2.3 1 1 0 1 1 1 1 Major Facilitator Superfamily RRM_1 PF00076.22 CCF33781.1 - 4.2e-14 52.1 0.1 6.2e-07 29.2 0.0 2.7 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Peptidase_M14 PF00246.24 CCF33782.1 - 1.6e-74 251.3 0.0 1.9e-74 251.0 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase Dynamin_N PF00350.23 CCF33783.1 - 8.5e-16 58.5 0.1 1.1e-14 54.9 0.0 2.8 3 1 0 3 3 3 1 Dynamin family MMR_HSR1 PF01926.23 CCF33783.1 - 0.00069 19.7 0.2 0.023 14.8 0.2 2.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.27 CCF33783.1 - 0.011 16.3 0.6 0.074 13.6 0.0 2.7 3 0 0 3 3 3 0 ABC transporter RsgA_GTPase PF03193.16 CCF33783.1 - 0.012 15.6 0.0 0.082 12.8 0.0 2.4 2 0 0 2 2 2 0 RsgA GTPase GTP_EFTU PF00009.27 CCF33783.1 - 0.012 15.1 1.8 0.91 9.0 0.4 3.4 2 1 0 3 3 3 0 Elongation factor Tu GTP binding domain AIG1 PF04548.16 CCF33783.1 - 0.012 14.9 0.0 0.041 13.2 0.0 1.9 1 0 0 1 1 1 0 AIG1 family EcoEI_R_C PF08463.10 CCF33783.1 - 0.046 13.8 0.3 0.17 12.0 0.3 2.1 1 0 0 1 1 1 0 EcoEI R protein C-terminal IIGP PF05049.13 CCF33783.1 - 0.065 12.3 1.0 0.24 10.4 0.0 2.4 4 0 0 4 4 4 0 Interferon-inducible GTPase (IIGP) AAA_22 PF13401.6 CCF33783.1 - 0.094 13.0 0.0 20 5.4 0.0 3.9 3 0 0 3 3 3 0 AAA domain AAA_16 PF13191.6 CCF33783.1 - 0.12 12.8 0.0 0.12 12.8 0.0 3.5 3 1 1 4 4 4 0 AAA ATPase domain DUF87 PF01935.17 CCF33783.1 - 0.47 10.5 0.0 0.47 10.5 0.0 3.4 3 1 1 4 4 4 0 Helicase HerA, central domain Ammonium_transp PF00909.21 CCF33784.1 - 7.7e-96 321.2 22.1 9.5e-96 320.9 22.1 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family DUF3267 PF11667.8 CCF33784.1 - 0.37 11.1 0.1 0.37 11.1 0.1 3.9 5 1 1 6 6 6 0 Putative zincin peptidase DUF3445 PF11927.8 CCF33785.1 - 2.8e-72 243.0 0.0 3.6e-72 242.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3445) Fas_alpha_ACP PF18325.1 CCF33789.1 - 1.1e-45 156.0 0.0 1.9e-45 155.1 0.0 1.4 1 0 0 1 1 1 1 Fatty acid synthase subunit alpha Acyl carrier domain FAS_I_H PF18314.1 CCF33789.1 - 6.1e-35 120.7 0.0 1.1e-34 119.8 0.0 1.3 1 0 0 1 1 1 1 Fatty acid synthase type I helical domain ketoacyl-synt PF00109.26 CCF33789.1 - 5.1e-21 75.4 0.0 1.5e-20 73.8 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain p450 PF00067.22 CCF33790.1 - 2.2e-63 214.6 0.0 2.8e-63 214.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 PE PF00934.20 CCF33790.1 - 0.051 13.9 0.8 0.11 12.8 0.8 1.5 1 0 0 1 1 1 0 PE family Aminotran_4 PF01063.19 CCF33791.1 - 0.00086 19.2 0.0 0.0011 18.9 0.0 1.2 1 0 0 1 1 1 1 Amino-transferase class IV Abhydrolase_6 PF12697.7 CCF33792.1 - 0.011 16.3 4.7 0.011 16.3 4.7 2.0 2 1 0 2 2 2 0 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CCF33792.1 - 0.018 14.7 0.0 0.05 13.3 0.0 1.7 1 1 0 1 1 1 0 alpha/beta hydrolase fold Methyltransf_2 PF00891.18 CCF33793.1 - 1.1e-15 57.5 0.0 7.4e-09 35.2 0.0 2.2 2 0 0 2 2 2 2 O-methyltransferase domain DUF3662 PF12401.8 CCF33793.1 - 0.041 14.3 0.0 0.098 13.0 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2662) Med4 PF10018.9 CCF33794.1 - 2.5e-12 46.9 4.9 6e-12 45.7 4.8 1.6 1 1 1 2 2 2 1 Vitamin-D-receptor interacting Mediator subunit 4 DUF4011 PF13195.6 CCF33794.1 - 0.02 14.8 0.3 0.021 14.7 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4011) UDPG_MGDP_dh_C PF03720.15 CCF33794.1 - 0.027 14.9 0.2 0.042 14.3 0.2 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain DUF1943 PF09172.11 CCF33794.1 - 0.087 12.0 0.6 0.1 11.8 0.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1943) Casc1_N PF15927.5 CCF33794.1 - 2.8 7.6 16.4 3.9 7.1 16.4 1.2 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 N-terminus EMP70 PF02990.16 CCF33795.1 - 1.1e-201 671.0 8.0 1.7e-201 670.5 8.0 1.2 1 0 0 1 1 1 1 Endomembrane protein 70 Sas10_Utp3 PF04000.15 CCF33796.1 - 4.3e-17 62.5 0.9 4.3e-17 62.5 0.9 2.0 2 0 0 2 2 2 1 Sas10/Utp3/C1D family FMO-like PF00743.19 CCF33797.1 - 6.6e-18 64.4 0.0 3.6e-17 62.0 0.0 2.0 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 CCF33797.1 - 1.9e-17 63.5 0.4 1.1e-15 57.6 0.7 2.3 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CCF33797.1 - 1.3e-12 47.6 0.1 7.2e-11 41.8 0.1 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CCF33797.1 - 4.9e-12 45.7 0.0 3.7e-09 36.2 0.0 2.9 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 CCF33797.1 - 5.9e-06 26.4 0.4 2.9e-05 24.2 0.1 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 CCF33797.1 - 0.00025 21.6 4.1 0.058 14.0 0.0 2.7 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 CCF33797.1 - 0.00035 19.9 0.6 0.1 11.9 0.2 2.2 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_9 PF13454.6 CCF33797.1 - 0.0013 18.7 2.1 0.35 10.9 0.1 3.7 4 0 0 4 4 4 1 FAD-NAD(P)-binding Shikimate_DH PF01488.20 CCF33797.1 - 0.0014 18.7 0.0 2.7 8.1 0.0 2.4 2 0 0 2 2 2 2 Shikimate / quinate 5-dehydrogenase DAO PF01266.24 CCF33797.1 - 0.0041 16.8 9.6 0.058 13.0 9.6 2.8 1 1 0 1 1 1 1 FAD dependent oxidoreductase 3HCDH_N PF02737.18 CCF33797.1 - 0.0097 15.8 0.2 0.016 15.1 0.2 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain HI0933_like PF03486.14 CCF33797.1 - 0.028 13.1 1.9 0.54 8.9 0.6 2.8 3 0 0 3 3 3 0 HI0933-like protein NAD_binding_7 PF13241.6 CCF33797.1 - 0.086 13.3 0.1 2 8.9 0.1 2.4 2 1 0 2 2 2 0 Putative NAD(P)-binding FAD_binding_2 PF00890.24 CCF33797.1 - 0.83 8.7 6.6 0.074 12.1 1.9 1.6 2 0 0 2 2 2 0 FAD binding domain AAA_11 PF13086.6 CCF33798.1 - 1.5e-17 64.2 0.0 2.3e-17 63.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_12 PF13087.6 CCF33798.1 - 2.5e-13 50.1 0.0 4.4e-13 49.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 CCF33798.1 - 0.011 15.5 0.0 2.5 7.8 0.0 3.0 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase AAA_30 PF13604.6 CCF33798.1 - 0.011 15.5 0.1 1.3 8.7 0.0 2.4 2 1 0 2 2 2 0 AAA domain AAA_19 PF13245.6 CCF33798.1 - 0.039 14.3 0.1 0.98 9.7 0.1 2.6 1 1 0 1 1 1 0 AAA domain TPR_MLP1_2 PF07926.12 CCF33798.1 - 0.12 12.5 0.1 0.22 11.6 0.1 1.4 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein FtsK_SpoIIIE PF01580.18 CCF33798.1 - 0.13 11.6 0.0 0.26 10.6 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family UvrD_C_2 PF13538.6 CCF33798.1 - 0.15 11.9 0.0 0.5 10.2 0.0 1.9 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain Adeno_E3_CR2 PF02439.15 CCF33799.1 - 0.27 11.0 3.6 0.47 10.3 3.6 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 KH_6 PF15985.5 CCF33800.1 - 1.1e-17 64.1 0.2 2.6e-17 62.9 0.0 1.8 2 0 0 2 2 2 1 KH domain Rrp40_N PF18311.1 CCF33800.1 - 6.5e-17 61.2 1.5 6.5e-17 61.2 1.5 1.8 2 0 0 2 2 2 1 Exosome complex exonuclease Rrp40 N-terminal domain HSP70 PF00012.20 CCF33801.1 - 2.6e-78 263.7 4.2 4e-78 263.1 4.2 1.3 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 CCF33801.1 - 3e-09 36.2 0.5 4.9e-09 35.5 0.5 1.3 1 0 0 1 1 1 1 MreB/Mbl protein PilM_2 PF11104.8 CCF33801.1 - 0.00069 18.7 0.3 1.2 8.1 0.0 2.7 2 1 1 3 3 3 2 Type IV pilus assembly protein PilM; Hydantoinase_A PF01968.18 CCF33801.1 - 0.0045 16.3 0.2 0.047 13.0 0.1 2.5 1 1 2 3 3 3 1 Hydantoinase/oxoprolinase NT-C2 PF10358.9 CCF33802.1 - 1.8e-27 95.9 0.9 2.2e-26 92.3 0.9 2.1 1 1 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins SUIM_assoc PF16619.5 CCF33802.1 - 0.029 14.4 3.9 0.068 13.2 3.9 1.6 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 ANT PF03374.14 CCF33802.1 - 0.21 11.9 1.3 0.4 11.0 1.3 1.4 1 0 0 1 1 1 0 Phage antirepressor protein KilAC domain DUF1275 PF06912.11 CCF33803.1 - 2.8e-49 167.7 6.8 3.6e-49 167.3 6.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1275) DUF4131 PF13567.6 CCF33803.1 - 1.9 8.1 9.3 5.4 6.6 0.6 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4131) Glyco_hydro_16 PF00722.21 CCF33804.1 - 5.5e-37 126.9 2.5 1.1e-36 126.0 2.5 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Fungal_trans_2 PF11951.8 CCF33806.1 - 9.6e-47 159.6 0.0 1.3e-46 159.2 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF33806.1 - 6.3e-07 29.4 6.0 1.2e-06 28.5 6.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ADH_N PF08240.12 CCF33807.1 - 4.3e-24 84.5 3.4 1.1e-23 83.2 3.4 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCF33807.1 - 5e-16 58.9 0.1 8.3e-16 58.2 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 CCF33807.1 - 1.4e-05 24.7 0.4 0.00032 20.2 0.3 2.2 2 0 0 2 2 2 1 Glucose dehydrogenase C-terminus UDPG_MGDP_dh_N PF03721.14 CCF33807.1 - 0.092 12.3 0.1 0.24 10.9 0.1 1.6 1 1 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain TrkA_N PF02254.18 CCF33807.1 - 0.11 12.7 0.1 0.23 11.7 0.1 1.6 1 0 0 1 1 1 0 TrkA-N domain PglD_N PF17836.1 CCF33807.1 - 0.12 13.0 0.0 2.2 9.0 0.0 2.3 2 0 0 2 2 2 0 PglD N-terminal domain adh_short_C2 PF13561.6 CCF33808.1 - 2.8e-61 207.1 1.0 3.2e-61 206.9 1.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF33808.1 - 1.6e-52 177.9 1.2 2.2e-52 177.4 1.2 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF33808.1 - 7.9e-16 58.5 0.1 1.2e-15 57.9 0.1 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF33808.1 - 1.1e-05 25.1 0.8 7.3e-05 22.3 0.8 2.2 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family FMN_dh PF01070.18 CCF33808.1 - 0.067 12.2 0.0 0.098 11.7 0.0 1.2 1 0 0 1 1 1 0 FMN-dependent dehydrogenase p450 PF00067.22 CCF33809.1 - 3.4e-38 131.6 0.0 4.2e-38 131.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Sugar_tr PF00083.24 CCF33810.1 - 2e-92 310.5 16.0 2.4e-92 310.2 16.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF33810.1 - 2e-22 79.6 56.3 3.8e-15 55.7 32.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Aminotran_1_2 PF00155.21 CCF33811.1 - 1.5e-38 133.0 0.0 1.8e-38 132.7 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 CCF33811.1 - 4.1e-07 29.3 0.0 9.5e-07 28.1 0.0 1.5 2 0 0 2 2 2 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 CCF33811.1 - 3.8e-05 23.1 0.0 5.6e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.20 CCF33811.1 - 4.1e-05 22.3 0.0 5.9e-05 21.8 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_MocR PF12897.7 CCF33811.1 - 0.00015 20.7 0.0 0.00019 20.3 0.0 1.1 1 0 0 1 1 1 1 Alanine-glyoxylate amino-transferase Alliinase_C PF04864.13 CCF33811.1 - 0.056 12.3 0.1 0.12 11.2 0.1 1.6 1 1 0 1 1 1 0 Allinase CPSase_L_D2 PF02786.17 CCF33812.1 - 7.7e-73 244.5 0.0 1.3e-72 243.7 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_C PF02785.19 CCF33812.1 - 9.4e-39 131.9 0.0 2.3e-37 127.4 0.0 2.4 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain Biotin_carb_N PF00289.22 CCF33812.1 - 9.3e-37 126.0 0.0 2.5e-36 124.5 0.0 1.8 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_lipoyl PF00364.22 CCF33812.1 - 4.3e-15 55.3 0.6 4.3e-15 55.3 0.6 2.5 3 0 0 3 3 3 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 CCF33812.1 - 4.6e-07 29.6 0.0 1.5e-06 27.9 0.0 1.8 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus Biotin_lipoyl_2 PF13533.6 CCF33812.1 - 2.4e-06 27.3 0.2 0.02 14.7 0.0 3.1 2 1 1 3 3 3 2 Biotin-lipoyl like HlyD_3 PF13437.6 CCF33812.1 - 0.00031 21.4 0.1 1.1 10.0 0.0 3.0 3 0 0 3 3 2 2 HlyD family secretion protein ATP-grasp_3 PF02655.14 CCF33812.1 - 0.0019 18.3 0.0 0.0058 16.7 0.0 1.9 2 0 0 2 2 2 1 ATP-grasp domain RimK PF08443.11 CCF33812.1 - 0.003 17.2 0.0 0.022 14.4 0.0 2.1 1 1 0 1 1 1 1 RimK-like ATP-grasp domain CoA_binding_2 PF13380.6 CCF33812.1 - 0.0094 16.4 0.0 0.44 11.1 0.0 3.0 2 1 0 2 2 2 1 CoA binding domain HlyD_D23 PF16576.5 CCF33812.1 - 0.044 13.0 0.1 7.9 5.6 0.0 2.6 1 1 1 2 2 2 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion Putative_PNPOx PF01243.20 CCF33813.1 - 6.5e-13 48.7 0.0 8.1e-13 48.4 0.0 1.1 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Gpi16 PF04113.14 CCF33813.1 - 0.002 16.7 0.2 0.0021 16.6 0.2 1.0 1 0 0 1 1 1 1 Gpi16 subunit, GPI transamidase component Pyridox_ox_2 PF12900.7 CCF33813.1 - 0.067 13.2 0.0 0.086 12.8 0.0 1.1 1 0 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase Epimerase PF01370.21 CCF33814.1 - 4.8e-10 39.3 0.0 2.6e-09 36.9 0.0 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 CCF33814.1 - 2e-06 27.2 0.0 2.8e-06 26.7 0.0 1.1 1 0 0 1 1 1 1 Male sterility protein 3Beta_HSD PF01073.19 CCF33814.1 - 6.9e-05 22.0 0.0 0.00021 20.4 0.0 1.7 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Aldedh PF00171.22 CCF33815.1 - 1.5e-117 393.0 0.2 3.9e-116 388.3 0.2 2.0 1 1 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 CCF33815.1 - 0.00023 20.4 0.0 0.00067 18.8 0.0 1.6 1 1 0 1 1 1 1 Acyl-CoA reductase (LuxC) OmdA PF13376.6 CCF33815.1 - 0.17 11.9 0.1 0.29 11.2 0.1 1.3 1 0 0 1 1 1 0 Bacteriocin-protection, YdeI or OmpD-Associated Ald_Xan_dh_C2 PF02738.18 CCF33816.1 - 2.9e-159 531.0 0.2 4.3e-159 530.5 0.2 1.2 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.21 CCF33816.1 - 7.7e-48 162.4 0.0 2e-47 161.1 0.0 1.7 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase Ald_Xan_dh_C PF01315.22 CCF33816.1 - 1.8e-32 112.0 0.0 3.7e-32 111.0 0.0 1.6 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain CO_deh_flav_C PF03450.17 CCF33816.1 - 3.1e-31 107.6 0.8 9.5e-31 106.0 0.1 2.3 2 0 0 2 2 2 1 CO dehydrogenase flavoprotein C-terminal domain Fer2_2 PF01799.20 CCF33816.1 - 2.8e-30 104.1 0.1 6e-30 103.1 0.1 1.6 1 0 0 1 1 1 1 [2Fe-2S] binding domain Fer2 PF00111.27 CCF33816.1 - 2.5e-08 33.7 1.6 5.7e-08 32.6 0.1 2.5 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain DUF218 PF02698.17 CCF33816.1 - 0.0035 17.4 0.0 0.01 15.9 0.0 1.7 1 0 0 1 1 1 1 DUF218 domain Iso_dh PF00180.20 CCF33817.1 - 4e-80 269.6 0.0 4.7e-80 269.3 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase adh_short PF00106.25 CCF33820.1 - 3.6e-23 82.0 0.0 3e-21 75.8 0.0 2.1 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF33820.1 - 7.5e-11 42.0 0.0 4.4e-10 39.5 0.0 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF33820.1 - 3.3e-07 30.4 0.1 5.3e-07 29.7 0.1 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF33820.1 - 0.032 13.7 0.1 0.11 11.9 0.0 2.0 2 1 0 2 2 2 0 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 CCF33820.1 - 0.052 12.7 0.0 0.087 11.9 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein MAP17 PF15807.5 CCF33820.1 - 0.1 12.8 0.0 0.16 12.2 0.0 1.2 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 V-SNARE PF05008.15 CCF33820.1 - 0.22 11.9 0.0 0.71 10.3 0.0 1.8 2 0 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus HET PF06985.11 CCF33822.1 - 3.5e-23 82.6 0.0 5.6e-23 81.9 0.0 1.3 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Abhydrolase_6 PF12697.7 CCF33823.1 - 1.9e-11 45.0 1.1 2.2e-11 44.8 1.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CCF33823.1 - 5.3e-08 32.8 0.0 1.3e-07 31.5 0.0 1.6 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CCF33823.1 - 0.001 18.4 0.0 0.0016 17.8 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF1057 PF06342.12 CCF33823.1 - 0.027 13.5 0.0 0.041 12.9 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) ARD PF03079.14 CCF33824.1 - 1.8e-45 154.9 0.8 2.2e-45 154.7 0.8 1.1 1 0 0 1 1 1 1 ARD/ARD' family Cupin_2 PF07883.11 CCF33824.1 - 7.4e-09 35.2 0.2 1.3e-08 34.5 0.2 1.3 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 CCF33824.1 - 0.00082 19.3 0.1 0.0011 18.9 0.1 1.3 1 0 0 1 1 1 1 AraC-like ligand binding domain DER1 PF04511.15 CCF33825.1 - 4.9e-52 176.7 5.6 5.6e-52 176.5 5.6 1.0 1 0 0 1 1 1 1 Der1-like family Histone PF00125.24 CCF33826.1 - 4.3e-42 143.6 1.2 4.8e-42 143.4 1.2 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 CCF33826.1 - 2.1e-06 27.8 0.0 3.3e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 CCF33826.1 - 0.00011 22.5 0.1 0.00016 22.0 0.1 1.2 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 CCF33826.1 - 0.0065 16.7 0.1 0.0095 16.2 0.1 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 CCF33826.1 - 0.08 13.0 0.0 0.11 12.6 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Creatinase_N_2 PF16189.5 CCF33827.1 - 2.6e-52 177.1 0.0 1e-51 175.2 0.0 2.0 2 0 0 2 2 2 1 Creatinase/Prolidase N-terminal domain Peptidase_M24 PF00557.24 CCF33827.1 - 7.3e-44 150.0 0.1 9.9e-44 149.5 0.1 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Peptidase_M24_C PF16188.5 CCF33827.1 - 3.9e-22 78.1 0.4 1.1e-21 76.6 0.4 1.8 1 0 0 1 1 1 1 C-terminal region of peptidase_M24 Creatinase_N PF01321.18 CCF33827.1 - 2.8e-09 37.7 0.0 3.1e-05 24.6 0.0 2.5 2 0 0 2 2 2 2 Creatinase/Prolidase N-terminal domain DUF1335 PF07056.11 CCF33827.1 - 0.15 12.2 0.0 0.29 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1335) p450 PF00067.22 CCF33828.1 - 1.4e-68 231.8 0.0 1.6e-68 231.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 HMG_CoA_synt_C PF08540.10 CCF33829.1 - 2.9e-95 319.1 0.1 3.8e-95 318.7 0.1 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.17 CCF33829.1 - 1.5e-61 207.3 0.2 2.3e-61 206.7 0.2 1.3 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal ArfGap PF01412.18 CCF33832.1 - 4.7e-36 123.4 0.1 5.5e-36 123.2 0.1 1.0 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf DZR PF12773.7 CCF33832.1 - 0.065 13.3 0.2 0.11 12.5 0.2 1.3 1 0 0 1 1 1 0 Double zinc ribbon TIM21 PF08294.11 CCF33833.1 - 7.3e-46 155.7 0.0 8.9e-46 155.4 0.0 1.1 1 0 0 1 1 1 1 TIM21 Coa1 PF08695.10 CCF33833.1 - 6.5e-07 29.1 0.0 9.7e-07 28.5 0.0 1.2 1 0 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 RNA_pol_Rpb2_6 PF00562.28 CCF33834.1 - 4.1e-121 404.7 0.0 6.3e-121 404.1 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 CCF33834.1 - 2.2e-54 184.1 0.2 3.9e-54 183.3 0.2 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_7 PF04560.20 CCF33834.1 - 1e-33 115.5 0.6 2.5e-33 114.3 0.6 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_2 PF04561.14 CCF33834.1 - 1.6e-30 106.1 0.1 3.5e-30 105.0 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_4 PF04566.13 CCF33834.1 - 3e-22 78.7 0.2 7.7e-22 77.3 0.2 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.16 CCF33834.1 - 2.4e-19 69.3 0.0 4.8e-19 68.3 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 CCF33834.1 - 3.2e-10 40.4 2.4 1.1e-09 38.6 2.4 2.0 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 5 DNA_mis_repair PF01119.19 CCF33836.1 - 3e-20 72.1 0.0 6.6e-20 71.0 0.0 1.5 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain MutL_C PF08676.11 CCF33836.1 - 2e-19 69.8 0.0 4.6e-19 68.6 0.0 1.6 1 0 0 1 1 1 1 MutL C terminal dimerisation domain HATPase_c_3 PF13589.6 CCF33836.1 - 1.3e-11 44.5 0.1 3.5e-11 43.1 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 CCF33836.1 - 5.5e-07 30.1 0.0 1.5e-06 28.7 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Helo_like_N PF17111.5 CCF33837.1 - 1.2e-09 37.9 4.2 8.1e-07 28.6 0.0 3.1 2 1 1 3 3 3 1 Fungal N-terminal domain of STAND proteins V-SNARE PF05008.15 CCF33837.1 - 4.7e-06 26.9 5.7 0.0004 20.7 0.1 3.6 3 0 0 3 3 3 1 Vesicle transport v-SNARE protein N-terminus SesA PF17107.5 CCF33837.1 - 0.0039 17.4 1.3 0.12 12.6 0.0 2.9 3 0 0 3 3 3 1 N-terminal domain on NACHT_NTPase and P-loop NTPases Baculo_PEP_C PF04513.12 CCF33837.1 - 0.097 12.7 3.4 1.4 8.9 0.9 2.9 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Adaptin_binding PF10199.9 CCF33837.1 - 0.1 13.2 0.2 0.91 10.1 0.0 2.4 3 1 0 3 3 3 0 Alpha and gamma adaptin binding protein p34 DUF1664 PF07889.12 CCF33837.1 - 0.1 12.6 6.0 0.1 12.6 1.8 3.0 3 1 0 3 3 3 0 Protein of unknown function (DUF1664) Med9 PF07544.13 CCF33837.1 - 0.17 12.0 0.1 0.17 12.0 0.1 3.0 3 0 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 CHDCT2 PF08074.11 CCF33837.1 - 0.19 11.9 1.5 5.5 7.1 0.1 3.0 3 0 0 3 3 3 0 CHDCT2 (NUC038) domain BLOC1_2 PF10046.9 CCF33837.1 - 0.26 11.6 6.2 14 6.1 0.1 3.7 3 2 1 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 NPV_P10 PF05531.12 CCF33837.1 - 0.74 10.3 4.6 11 6.5 0.7 3.6 3 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein CREPT PF16566.5 CCF33837.1 - 2.2 8.4 5.9 0.46 10.6 0.3 2.6 3 1 0 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour MutS_III PF05192.18 CCF33837.1 - 4.6 7.4 5.7 45 4.2 5.7 2.5 1 1 0 1 1 1 0 MutS domain III DUF3450 PF11932.8 CCF33837.1 - 6 6.1 8.2 3.1 7.0 1.4 3.5 2 1 2 4 4 4 0 Protein of unknown function (DUF3450) Epimerase PF01370.21 CCF33839.1 - 2e-14 53.6 0.0 5e-14 52.3 0.0 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CCF33839.1 - 5.8e-12 45.2 0.0 1.2e-11 44.2 0.0 1.5 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 CCF33839.1 - 8.7e-09 35.5 0.0 1.3e-08 35.0 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 CCF33839.1 - 4e-08 33.0 0.0 2.8e-07 30.2 0.0 1.9 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 CCF33839.1 - 1.3e-07 31.1 0.1 0.00045 19.5 0.0 2.1 2 0 0 2 2 2 2 Male sterility protein NmrA PF05368.13 CCF33839.1 - 5.1e-06 26.2 0.0 7.5e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family Polysacc_synt_2 PF02719.15 CCF33839.1 - 0.00015 21.0 0.0 0.00025 20.3 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.25 CCF33839.1 - 0.00056 19.4 0.0 0.0025 17.3 0.0 1.9 2 0 0 2 2 2 1 short chain dehydrogenase Gpi1 PF05024.15 CCF33841.1 - 1.2e-74 250.4 7.1 2.2e-74 249.6 7.1 1.4 1 0 0 1 1 1 1 N-acetylglucosaminyl transferase component (Gpi1) 7tm_1 PF00001.21 CCF33841.1 - 0.019 14.3 0.9 0.054 12.8 0.9 1.7 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) ABC_membrane PF00664.23 CCF33842.1 - 1.4e-64 218.4 21.3 4.7e-45 154.4 6.3 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 CCF33842.1 - 9.5e-29 100.7 0.1 2.7e-28 99.2 0.0 1.9 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.19 CCF33842.1 - 4.3e-07 29.6 0.0 0.00015 21.3 0.0 2.4 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 CCF33842.1 - 0.0049 17.3 0.2 0.016 15.6 0.2 2.0 1 1 0 1 1 1 1 AAA ATPase domain APS_kinase PF01583.20 CCF33842.1 - 0.034 14.1 0.1 0.067 13.1 0.1 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_29 PF13555.6 CCF33842.1 - 0.035 13.8 0.3 0.088 12.6 0.3 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Zeta_toxin PF06414.12 CCF33842.1 - 0.038 13.3 0.0 0.07 12.4 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_22 PF13401.6 CCF33842.1 - 0.062 13.6 0.1 1.2 9.5 0.1 2.6 1 1 0 1 1 1 0 AAA domain DUF87 PF01935.17 CCF33842.1 - 0.079 13.0 1.5 0.1 12.6 0.4 1.7 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_33 PF13671.6 CCF33842.1 - 0.18 12.0 0.0 0.57 10.3 0.0 1.8 2 0 0 2 2 2 0 AAA domain Pyr_redox_2 PF07992.14 CCF33843.1 - 4.1e-26 91.9 0.0 6.4e-26 91.3 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCF33843.1 - 3.9e-13 49.8 0.5 6.8e-12 45.8 0.1 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CCF33843.1 - 0.00019 20.7 0.1 0.00036 19.8 0.0 1.4 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Lycopene_cycl PF05834.12 CCF33843.1 - 0.0017 17.5 0.0 0.0028 16.8 0.0 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein HI0933_like PF03486.14 CCF33843.1 - 0.0068 15.1 0.1 0.45 9.2 0.1 2.1 2 0 0 2 2 2 2 HI0933-like protein Pyr_redox_3 PF13738.6 CCF33843.1 - 0.01 15.1 0.3 0.029 13.6 0.1 1.9 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 CCF33843.1 - 0.021 13.7 0.0 4.2 6.1 0.2 2.1 2 0 0 2 2 2 0 Tryptophan halogenase DAO PF01266.24 CCF33843.1 - 0.05 13.2 0.1 0.15 11.6 0.1 1.8 2 0 0 2 2 2 0 FAD dependent oxidoreductase HEAT PF02985.22 CCF33845.1 - 0.0011 19.1 5.4 7.1 7.2 0.0 5.6 6 0 0 6 6 6 1 HEAT repeat Cnd1 PF12717.7 CCF33845.1 - 0.0011 19.0 0.2 0.52 10.3 0.1 4.2 3 2 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 Nitr_red_assoc PF09655.10 CCF33845.1 - 0.002 18.8 0.6 1.4 9.5 0.0 3.2 3 0 0 3 3 3 2 Conserved nitrate reductase-associated protein (Nitr_red_assoc) HEAT_EZ PF13513.6 CCF33845.1 - 0.0043 17.5 0.8 0.36 11.4 0.0 4.4 4 0 0 4 4 4 1 HEAT-like repeat F_actin_bind PF08919.10 CCF33845.1 - 0.015 15.4 0.1 0.71 10.0 0.0 3.5 3 0 0 3 3 3 0 F-actin binding HEAT_2 PF13646.6 CCF33845.1 - 0.036 14.5 3.2 1 9.8 0.1 4.3 4 0 0 4 4 4 0 HEAT repeats GFO_IDH_MocA_C PF02894.17 CCF33846.1 - 1.5e-17 63.7 0.4 5.8e-17 61.8 0.3 2.1 2 0 0 2 2 2 1 Oxidoreductase family, C-terminal alpha/beta domain GFO_IDH_MocA PF01408.22 CCF33846.1 - 7.3e-16 59.1 0.0 1.3e-15 58.2 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold MFS_1 PF07690.16 CCF33847.1 - 1.6e-31 109.6 31.8 1.6e-31 109.6 31.8 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily WSC PF01822.19 CCF33848.1 - 3.5e-21 75.2 8.0 3.6e-21 75.2 6.2 1.8 2 0 0 2 2 2 1 WSC domain Fungal_trans PF04082.18 CCF33850.1 - 1.5e-14 53.7 0.0 2.5e-14 53.0 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF33850.1 - 1.8e-05 24.7 6.8 3.2e-05 23.9 6.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain YqeY PF09424.10 CCF33851.1 - 1.6e-23 83.3 2.4 2.1e-23 83.0 2.4 1.1 1 0 0 1 1 1 1 Yqey-like protein DUF2017 PF09438.10 CCF33851.1 - 0.0011 18.9 3.9 0.0014 18.6 3.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF2017) KI67R PF08065.12 CCF33851.1 - 0.15 12.6 0.7 0.21 12.2 0.7 1.2 1 0 0 1 1 1 0 KI67R (NUC007) repeat Methyltransf_25 PF13649.6 CCF33853.1 - 3.5e-12 46.9 0.0 6.7e-12 46.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF33853.1 - 7.4e-12 45.4 0.0 1.3e-11 44.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF33853.1 - 4.2e-09 36.9 0.0 7.4e-09 36.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 CCF33853.1 - 0.0004 19.9 0.0 0.00076 19.0 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_12 PF08242.12 CCF33853.1 - 0.0007 20.3 0.0 0.0014 19.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 CCF33853.1 - 0.039 13.2 0.0 0.12 11.6 0.0 1.9 3 0 0 3 3 3 0 O-methyltransferase domain Ubie_methyltran PF01209.18 CCF33853.1 - 0.043 13.2 0.0 0.23 10.8 0.0 2.1 1 1 1 2 2 2 0 ubiE/COQ5 methyltransferase family Fimbrial_PilY2 PF14481.6 CCF33854.1 - 0.13 11.9 0.0 0.24 11.0 0.0 1.4 1 0 0 1 1 1 0 Type 4 fimbrial biogenesis protein PilY2 DUF3328 PF11807.8 CCF33854.1 - 0.22 11.3 3.7 0.6 9.8 3.7 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF3328) Acetyltransf_1 PF00583.25 CCF33855.1 - 1.3e-06 28.6 0.0 2.5e-06 27.7 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CCF33855.1 - 2e-06 28.1 0.0 4.6e-06 27.0 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CCF33855.1 - 8.2e-06 25.8 0.0 1.9e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 CCF33855.1 - 0.011 15.9 0.0 0.023 14.8 0.0 1.5 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase DUF3328 PF11807.8 CCF33856.1 - 0.033 14.0 4.4 0.24 11.1 4.4 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF3328) p450 PF00067.22 CCF33857.1 - 3.8e-41 141.3 0.0 7.7e-41 140.3 0.0 1.4 1 1 0 1 1 1 1 Cytochrome P450 Alpha-amylase PF00128.24 CCF33858.1 - 5.9e-48 164.2 0.0 1.3e-47 163.1 0.0 1.5 1 1 0 1 1 1 1 Alpha amylase, catalytic domain DUF1966 PF09260.11 CCF33858.1 - 3.7e-12 46.4 0.0 8.7e-12 45.2 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1966) PTR2 PF00854.21 CCF33859.1 - 2.2e-56 191.4 6.2 2.2e-56 191.4 6.2 1.5 1 1 0 1 1 1 1 POT family MFS_1 PF07690.16 CCF33859.1 - 1.6e-05 24.1 10.7 9.2e-05 21.5 9.4 2.0 2 0 0 2 2 2 1 Major Facilitator Superfamily Trep_Strep PF09605.10 CCF33859.1 - 6.3 6.7 10.2 5.1 7.0 1.8 2.9 3 0 0 3 3 3 0 Hypothetical bacterial integral membrane protein (Trep_Strep) DUF3792 PF12670.7 CCF33859.1 - 8.7 6.5 7.7 2.2 8.4 1.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3792) MFS_1 PF07690.16 CCF33860.1 - 1.6e-32 112.8 37.8 5.1e-32 111.2 35.6 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF33860.1 - 7.9e-11 41.5 8.0 7.9e-11 41.5 8.0 2.1 2 1 2 4 4 4 1 Sugar (and other) transporter TRI12 PF06609.13 CCF33860.1 - 0.009 14.5 4.2 0.013 13.9 4.2 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sm_multidrug_ex PF06695.11 CCF33860.1 - 0.01 16.5 1.6 4.7 7.9 3.3 2.8 2 0 0 2 2 2 0 Putative small multi-drug export protein DUF4381 PF14316.6 CCF33860.1 - 9.8 6.4 12.2 16 5.7 0.2 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4381) Velvet PF11754.8 CCF33861.1 - 1.4e-30 107.1 0.0 1.4e-30 107.1 0.0 2.7 2 1 0 2 2 2 1 Velvet factor DUF4636 PF15468.6 CCF33862.1 - 0.033 13.9 0.0 0.036 13.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4636) Dynamin_M PF01031.20 CCF33863.1 - 6.6e-109 363.5 0.0 1.3e-108 362.6 0.0 1.5 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.23 CCF33863.1 - 4.6e-57 192.7 0.6 7.6e-57 192.0 0.0 1.7 2 0 0 2 2 2 1 Dynamin family GED PF02212.18 CCF33863.1 - 1.7e-30 105.0 1.6 1.7e-30 105.0 1.6 2.2 3 0 0 3 3 3 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 CCF33863.1 - 4.7e-05 23.4 0.3 0.00055 20.0 0.3 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase Condensin2nSMC PF12422.8 CCF33863.1 - 0.039 14.1 0.0 0.48 10.6 0.0 2.3 2 0 0 2 2 2 0 Condensin II non structural maintenance of chromosomes subunit COX17 PF05051.13 CCF33864.1 - 0.001 19.4 2.8 0.076 13.4 0.3 2.0 1 1 1 2 2 2 2 Cytochrome C oxidase copper chaperone (COX17) CHCH PF06747.13 CCF33864.1 - 0.001 19.1 0.6 0.0029 17.7 0.6 1.7 1 1 1 2 2 2 1 CHCH domain Pet191_N PF10203.9 CCF33864.1 - 0.001 19.3 1.8 0.011 16.0 2.1 1.9 1 1 1 2 2 2 2 Cytochrome c oxidase assembly protein PET191 NDUF_B7 PF05676.13 CCF33864.1 - 0.011 15.4 0.5 0.011 15.4 0.5 1.1 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Cmc1 PF08583.10 CCF33864.1 - 0.047 13.7 1.9 0.15 12.1 1.9 1.7 1 1 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like UCR_hinge PF02320.16 CCF33864.1 - 0.063 13.5 1.6 0.25 11.6 1.6 1.8 1 1 0 1 1 1 0 Ubiquinol-cytochrome C reductase hinge protein UPF0203 PF05254.12 CCF33864.1 - 0.08 13.2 1.9 2.6 8.4 0.1 2.0 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0203) LIM PF00412.22 CCF33866.1 - 2.4e-16 59.7 20.7 8.5e-09 35.5 6.1 2.9 3 0 0 3 3 3 2 LIM domain DUF2321 PF10083.9 CCF33866.1 - 0.0049 16.5 0.4 0.0049 16.5 0.4 3.3 3 1 1 4 4 4 1 Uncharacterized protein conserved in bacteria (DUF2321) zf-dskA_traR PF01258.17 CCF33866.1 - 0.035 14.0 0.3 0.035 14.0 0.3 4.2 4 0 0 4 4 4 0 Prokaryotic dksA/traR C4-type zinc finger Rad60-SLD PF11976.8 CCF33867.1 - 4.3e-19 68.1 0.1 5e-19 67.9 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 CCF33867.1 - 1.8e-11 43.6 0.1 2.1e-11 43.4 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin family Lactamase_B PF00753.27 CCF33868.1 - 1.3e-07 31.9 0.2 3e-07 30.6 0.1 1.7 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Mito_carr PF00153.27 CCF33869.1 - 7.4e-17 61.1 0.0 6.5e-10 38.8 0.0 3.3 3 1 0 3 3 3 2 Mitochondrial carrier protein GMC_oxred_N PF00732.19 CCF33870.1 - 4.3e-52 177.3 0.0 5.8e-52 176.9 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCF33870.1 - 1.8e-26 93.4 0.0 3.2e-26 92.6 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase DAO PF01266.24 CCF33870.1 - 1.2e-06 28.4 1.0 2.6e-06 27.2 1.0 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CCF33870.1 - 6e-05 22.3 2.1 0.0028 16.8 0.2 2.4 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 CCF33870.1 - 0.00022 20.6 0.1 0.059 12.6 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCF33870.1 - 0.00025 20.4 0.4 0.0062 15.8 0.1 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCF33870.1 - 0.00099 19.3 0.5 0.0067 16.6 0.4 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 CCF33870.1 - 0.0013 18.1 0.1 0.0024 17.2 0.1 1.3 1 0 0 1 1 1 1 Thi4 family TrkA_N PF02254.18 CCF33870.1 - 0.059 13.6 1.7 0.097 12.9 0.4 2.0 2 0 0 2 2 2 0 TrkA-N domain HI0933_like PF03486.14 CCF33870.1 - 0.13 11.0 0.3 0.53 8.9 0.0 1.9 2 0 0 2 2 2 0 HI0933-like protein NAD_binding_9 PF13454.6 CCF33870.1 - 0.13 12.2 3.0 0.25 11.3 0.3 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding Lycopene_cycl PF05834.12 CCF33870.1 - 0.17 10.9 0.5 0.31 10.0 0.1 1.6 2 0 0 2 2 2 0 Lycopene cyclase protein 2OG-FeII_Oxy_2 PF13532.6 CCF33871.1 - 1.4e-31 110.2 0.0 4.5e-31 108.6 0.0 1.7 1 1 1 2 2 2 1 2OG-Fe(II) oxygenase superfamily Pkinase PF00069.25 CCF33872.1 - 1.5e-69 234.4 0.0 1.8e-69 234.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF33872.1 - 2.2e-30 105.8 0.0 2.9e-30 105.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 CCF33872.1 - 0.0022 17.0 0.0 0.016 14.2 0.0 1.9 2 0 0 2 2 2 1 Haspin like kinase domain Kinase-like PF14531.6 CCF33872.1 - 0.0029 17.0 0.0 0.0057 16.0 0.0 1.4 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 CCF33872.1 - 0.0062 16.5 0.1 0.012 15.6 0.1 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 CCF33872.1 - 0.032 13.3 0.0 0.049 12.7 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Methyltransf_2 PF00891.18 CCF33873.1 - 1.6e-20 73.4 0.0 2.5e-20 72.7 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain DUF1993 PF09351.10 CCF33874.1 - 3.6e-54 183.3 0.0 4e-54 183.1 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1993) V-SNARE PF05008.15 CCF33874.1 - 0.14 12.6 0.4 0.22 11.9 0.4 1.3 1 0 0 1 1 1 0 Vesicle transport v-SNARE protein N-terminus Ribosomal_S16 PF00886.19 CCF33876.1 - 2.6e-24 85.0 0.1 4.2e-24 84.4 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S16 Aa_trans PF01490.18 CCF33877.1 - 2.3e-90 303.3 19.3 2.3e-90 303.3 19.3 1.3 2 0 0 2 2 2 1 Transmembrane amino acid transporter protein TetR_C_28 PF17937.1 CCF33877.1 - 0.12 12.9 0.2 0.22 12.0 0.2 1.4 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Dynactin_p22 PF07426.11 CCF33878.1 - 0.00048 20.0 0.0 0.00056 19.8 0.0 1.1 1 0 0 1 1 1 1 Dynactin subunit p22 Pyridox_ox_2 PF12900.7 CCF33881.1 - 2.3e-37 128.1 0.0 3.7e-37 127.4 0.0 1.3 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase p450 PF00067.22 CCF33883.1 - 5.6e-76 256.2 0.0 6.7e-76 255.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 CcmH PF03918.14 CCF33883.1 - 0.14 11.4 0.0 6.4 6.1 0.0 2.3 2 0 0 2 2 2 0 Cytochrome C biogenesis protein Tautomerase_3 PF14832.6 CCF33884.1 - 2.6e-52 176.7 0.0 2.9e-52 176.5 0.0 1.0 1 0 0 1 1 1 1 Putative oxalocrotonate tautomerase enzyme CVNH PF08881.10 CCF33885.1 - 1.9e-37 128.0 0.4 3e-37 127.4 0.4 1.3 1 0 0 1 1 1 1 CVNH domain LysM PF01476.20 CCF33885.1 - 2.5e-15 56.2 0.1 4.4e-15 55.5 0.1 1.4 1 0 0 1 1 1 1 LysM domain Rick_17kDa_Anti PF05433.15 CCF33885.1 - 7.5e-05 22.5 4.8 7.5e-05 22.5 4.8 1.9 2 0 0 2 2 2 1 Glycine zipper 2TM domain Gly-zipper_Omp PF13488.6 CCF33885.1 - 0.046 13.7 6.3 0.11 12.5 6.3 1.6 1 0 0 1 1 1 0 Glycine zipper SelP_N PF04592.14 CCF33885.1 - 0.28 10.5 9.1 0.38 10.1 9.1 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Gly-zipper_YMGG PF13441.6 CCF33885.1 - 0.41 10.4 7.5 0.97 9.2 7.5 1.6 1 0 0 1 1 1 0 YMGG-like Gly-zipper Aldedh PF00171.22 CCF33886.1 - 4.6e-157 523.2 0.1 5.2e-157 523.1 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 CCF33886.1 - 0.022 14.2 0.0 0.26 10.7 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1487) 2OG-FeII_Oxy_3 PF13640.6 CCF33887.1 - 0.034 15.0 0.0 0.059 14.3 0.0 1.4 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Zn_clus PF00172.18 CCF33889.1 - 5.7 7.2 14.8 0.65 10.2 9.6 2.0 2 0 0 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain dCMP_cyt_deam_1 PF00383.23 CCF33890.1 - 8.9e-22 76.9 0.0 3.1e-21 75.1 0.0 1.9 1 1 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 CCF33890.1 - 2.4e-19 69.5 0.0 2.4e-08 33.8 0.0 2.6 3 0 0 3 3 3 2 MafB19-like deaminase Bd3614-deam PF14439.6 CCF33890.1 - 0.0012 19.0 4.3 0.0064 16.6 0.0 2.9 3 0 0 3 3 3 1 Bd3614-like deaminase Xan_ur_permease PF00860.20 CCF33891.1 - 1.2e-14 53.8 12.2 1.8e-14 53.3 12.2 1.2 1 0 0 1 1 1 1 Permease family Sulfate_transp PF00916.20 CCF33891.1 - 0.00016 20.6 3.1 0.00023 20.1 2.5 1.6 1 1 0 1 1 1 1 Sulfate permease family Androgen_recep PF02166.16 CCF33892.1 - 0.49 9.2 10.0 0.82 8.4 10.0 1.2 1 0 0 1 1 1 0 Androgen receptor Trimer_CC PF08954.11 CCF33892.1 - 0.89 9.2 4.7 9.4 5.9 0.6 2.7 2 0 0 2 2 2 0 Trimerisation motif p450 PF00067.22 CCF33894.1 - 9.8e-13 47.7 0.0 1.3e-12 47.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 GCV_H PF01597.19 CCF33895.1 - 0.072 13.0 1.0 0.14 12.1 1.0 1.5 1 0 0 1 1 1 0 Glycine cleavage H-protein Glyco_hydro_61 PF03443.14 CCF33897.1 - 1.8e-62 211.0 0.1 2.2e-62 210.7 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 DUF5624 PF18538.1 CCF33897.1 - 0.0037 17.4 0.0 0.0055 16.8 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF5624) Glyco_hydro_28 PF00295.17 CCF33898.1 - 2.2e-68 230.7 10.2 8.5e-57 192.6 4.0 2.0 2 0 0 2 2 2 2 Glycosyl hydrolases family 28 3-HAO PF06052.12 CCF33899.1 - 1.5e-65 219.5 0.0 1.7e-65 219.3 0.0 1.0 1 0 0 1 1 1 1 3-hydroxyanthranilic acid dioxygenase Cupin_2 PF07883.11 CCF33899.1 - 4.9e-06 26.2 0.0 7.5e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 CCF33899.1 - 0.00016 21.3 0.1 0.00025 20.7 0.1 1.2 1 0 0 1 1 1 1 Cupin DZR PF12773.7 CCF33899.1 - 0.0012 18.9 1.9 0.0043 17.1 1.9 1.9 1 1 0 1 1 1 1 Double zinc ribbon AraC_binding PF02311.19 CCF33899.1 - 0.0052 16.7 0.0 0.0087 16.0 0.0 1.3 1 0 0 1 1 1 1 AraC-like ligand binding domain zf-ACC PF17848.1 CCF33899.1 - 0.12 12.5 1.5 2.5 8.2 0.0 2.7 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain Nudix_N_2 PF14803.6 CCF33899.1 - 0.12 12.3 2.9 8.3 6.4 0.2 2.4 2 0 0 2 2 2 0 Nudix N-terminal RecR PF02132.15 CCF33899.1 - 0.14 11.7 1.7 0.44 10.2 0.0 2.2 2 0 0 2 2 2 0 RecR protein Cupin_4 PF08007.12 CCF33899.1 - 0.16 11.4 0.0 0.19 11.2 0.0 1.2 1 0 0 1 1 1 0 Cupin superfamily protein zf-ribbon_3 PF13248.6 CCF33899.1 - 0.18 11.2 0.1 0.18 11.2 0.1 1.8 2 0 0 2 2 2 0 zinc-ribbon domain Zn-ribbon_8 PF09723.10 CCF33899.1 - 0.21 11.8 1.7 0.52 10.5 0.3 2.1 2 0 0 2 2 2 0 Zinc ribbon domain ADK_lid PF05191.14 CCF33899.1 - 0.5 10.4 2.5 12 6.0 0.2 2.6 2 0 0 2 2 2 0 Adenylate kinase, active site lid FAA_hydrolase PF01557.18 CCF33900.1 - 2.5e-50 171.2 0.0 2.9e-50 171.0 0.0 1.0 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Pkinase_Tyr PF07714.17 CCF33902.1 - 2e-05 24.0 0.0 0.004 16.5 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 CCF33902.1 - 0.0072 15.7 0.0 0.014 14.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Zn_clus PF00172.18 CCF33903.1 - 1.9e-07 31.1 7.0 4e-07 30.1 7.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Helo_like_N PF17111.5 CCF33904.1 - 4e-07 29.6 0.0 4.5e-07 29.4 0.0 1.0 1 0 0 1 1 1 1 Fungal N-terminal domain of STAND proteins SesA PF17107.5 CCF33904.1 - 0.00085 19.5 0.1 0.00094 19.4 0.1 1.1 1 0 0 1 1 1 1 N-terminal domain on NACHT_NTPase and P-loop NTPases DUF3079 PF11278.8 CCF33905.1 - 0.67 9.8 7.3 11 5.9 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3079) Peptidase_S8 PF00082.22 CCF33906.1 - 3e-09 36.6 2.4 8.1e-09 35.1 2.4 1.7 1 1 0 1 1 1 1 Subtilase family zf-CCCH_4 PF18044.1 CCF33907.1 - 9.2e-08 31.7 2.6 1.4e-07 31.1 2.6 1.3 1 0 0 1 1 1 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 CCF33907.1 - 1e-06 28.5 5.9 2e-06 27.7 5.9 1.5 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH PF00642.24 CCF33907.1 - 8.4e-06 25.6 2.6 1.6e-05 24.7 2.6 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.5 CCF33907.1 - 0.002 18.3 0.6 0.0061 16.8 0.1 2.1 2 0 0 2 2 2 1 Zinc-finger containing family zf-CCCH_2 PF14608.6 CCF33907.1 - 0.006 17.0 2.3 0.0094 16.4 2.3 1.3 1 0 0 1 1 1 1 RNA-binding, Nab2-type zinc finger Torus PF16131.5 CCF33907.1 - 0.082 13.6 0.1 0.082 13.6 0.1 3.4 3 0 0 3 3 3 0 Torus domain Flavoprotein PF02441.19 CCF33908.1 - 7.1e-47 159.1 0.1 8.2e-47 158.9 0.1 1.0 1 0 0 1 1 1 1 Flavoprotein Mpp10 PF04006.12 CCF33909.1 - 1.4e-111 374.0 73.1 1.2e-110 370.8 73.1 2.0 1 1 0 1 1 1 1 Mpp10 protein EHN PF06441.12 CCF33910.1 - 2.2e-31 108.4 0.2 4.2e-31 107.5 0.2 1.5 1 0 0 1 1 1 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 CCF33910.1 - 3.7e-06 26.8 0.5 1e-05 25.3 0.1 1.8 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCF33910.1 - 0.0011 19.7 2.4 0.0027 18.3 2.4 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family PP2C PF00481.21 CCF33912.1 - 4.3e-59 200.3 0.0 8.4e-59 199.3 0.0 1.5 1 0 0 1 1 1 1 Protein phosphatase 2C LRR_8 PF13855.6 CCF33912.1 - 1.4e-36 124.0 58.6 6.2e-09 35.5 3.3 9.8 3 3 7 11 11 11 11 Leucine rich repeat Guanylate_cyc PF00211.20 CCF33912.1 - 2.1e-31 109.0 0.0 1.4e-30 106.3 0.0 2.0 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain LRR_4 PF12799.7 CCF33912.1 - 8.7e-28 95.9 76.5 0.00073 19.9 0.1 13.1 7 2 7 16 16 16 12 Leucine Rich repeats (2 copies) Ad_cyc_g-alpha PF08509.11 CCF33912.1 - 2.2e-23 81.7 1.6 5.5e-23 80.4 1.6 1.8 1 0 0 1 1 1 1 Adenylate cyclase G-alpha binding domain LRR_1 PF00560.33 CCF33912.1 - 5.8e-07 29.2 51.8 11 7.0 0.0 16.7 15 3 0 15 15 15 1 Leucine Rich Repeat LRR_9 PF14580.6 CCF33912.1 - 0.0029 17.1 21.3 0.11 12.0 1.9 4.5 2 1 1 4 4 4 3 Leucine-rich repeat LRR_6 PF13516.6 CCF33912.1 - 0.68 10.1 43.2 22 5.4 0.3 12.2 13 0 0 13 13 13 0 Leucine Rich repeat Androgen_recep PF02166.16 CCF33912.1 - 2.9 6.6 13.5 5.7 5.7 13.5 1.4 1 0 0 1 1 1 0 Androgen receptor PTR2 PF00854.21 CCF33915.1 - 2.8e-60 204.2 6.8 6.3e-60 203.1 6.8 1.5 1 1 0 1 1 1 1 POT family PalH PF08733.10 CCF33915.1 - 0.013 14.5 1.9 0.019 14.0 1.0 1.7 1 1 0 1 1 1 0 PalH/RIM21 GFA PF04828.14 CCF33916.1 - 4.1e-10 39.8 0.6 6.4e-10 39.2 0.6 1.3 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme E1_dh PF00676.20 CCF33918.1 - 2.8e-86 289.2 0.0 3.4e-86 288.9 0.0 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.21 CCF33918.1 - 0.00074 19.3 0.1 0.017 14.9 0.0 2.7 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DXP_synthase_N PF13292.6 CCF33918.1 - 0.21 10.8 0.0 0.41 9.8 0.0 1.4 1 0 0 1 1 1 0 1-deoxy-D-xylulose-5-phosphate synthase HECT PF00632.25 CCF33919.1 - 5.6e-77 259.2 0.0 8.4e-77 258.7 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) CLASP_N PF12348.8 CCF33919.1 - 0.013 15.1 0.1 0.11 12.1 0.0 2.3 2 0 0 2 2 2 0 CLASP N terminal HEAT PF02985.22 CCF33919.1 - 0.017 15.3 0.1 5.7 7.5 0.0 3.9 3 0 0 3 3 3 0 HEAT repeat Arm PF00514.23 CCF33919.1 - 0.022 14.8 12.5 12 6.1 0.1 7.2 7 1 1 8 8 8 0 Armadillo/beta-catenin-like repeat RRN3 PF05327.11 CCF33919.1 - 0.044 12.3 11.9 0.023 13.2 2.9 2.5 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 HEAT_EZ PF13513.6 CCF33919.1 - 0.058 13.9 0.0 0.76 10.4 0.0 3.0 2 0 0 2 2 2 0 HEAT-like repeat Sigma70_ner PF04546.13 CCF33919.1 - 0.76 9.6 16.0 0.36 10.7 4.6 3.1 3 0 0 3 3 3 0 Sigma-70, non-essential region GCIP PF13324.6 CCF33919.1 - 1.4 8.5 9.1 3.5 7.2 2.1 2.6 2 0 0 2 2 2 0 Grap2 and cyclin-D-interacting Sec3_C PF09763.9 CCF33920.1 - 1e-239 797.6 1.0 1.3e-239 797.3 1.0 1.0 1 0 0 1 1 1 1 Exocyst complex component Sec3 Sec3-PIP2_bind PF15277.6 CCF33920.1 - 6.4e-29 99.9 0.0 1.3e-28 99.0 0.0 1.6 1 0 0 1 1 1 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH Sec3_C_2 PF15278.6 CCF33920.1 - 0.01 16.1 0.0 0.031 14.6 0.0 1.8 1 0 0 1 1 1 0 Sec3 exocyst complex subunit Vps52 PF04129.12 CCF33920.1 - 0.018 13.8 0.4 0.057 12.2 0.1 1.8 2 0 0 2 2 2 0 Vps52 / Sac2 family MCM PF00493.23 CCF33921.1 - 3.7e-100 333.6 0.0 5.5e-100 333.1 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 CCF33921.1 - 7.1e-40 135.8 1.1 1.3e-39 135.0 1.1 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 CCF33921.1 - 1.1e-27 96.2 3.7 2.6e-27 95.1 3.7 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 CCF33921.1 - 5.8e-18 65.4 0.0 2e-17 63.7 0.0 2.0 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.21 CCF33921.1 - 2.1e-05 24.0 0.0 0.00043 19.7 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 CCF33921.1 - 7.2e-05 22.8 0.0 0.00029 20.8 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 CCF33921.1 - 0.0012 18.7 0.0 0.0046 16.8 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_2 PF17863.1 CCF33921.1 - 0.039 13.8 0.2 0.11 12.4 0.2 1.7 1 0 0 1 1 1 0 AAA lid domain Sigma54_activat PF00158.26 CCF33921.1 - 0.13 12.0 0.2 2.6 7.7 0.0 2.7 3 0 0 3 3 3 0 Sigma-54 interaction domain Oberon_cc PF16312.5 CCF33921.1 - 0.7 9.8 5.9 1.4 8.8 5.9 1.4 1 0 0 1 1 1 0 Coiled-coil region of Oberon Clat_adaptor_s PF01217.20 CCF33922.1 - 9.3e-17 61.3 0.2 5.2e-15 55.6 0.5 2.0 2 0 0 2 2 2 2 Clathrin adaptor complex small chain Sua5_yciO_yrdC PF01300.18 CCF33923.1 - 1.8e-52 177.4 0.0 2.9e-52 176.8 0.0 1.2 1 0 0 1 1 1 1 Telomere recombination SUA5 PF03481.13 CCF33923.1 - 6.5e-30 104.4 0.0 1e-29 103.8 0.0 1.3 1 0 0 1 1 1 1 Putative GTP-binding controlling metal-binding TetR_C_12 PF16914.5 CCF33924.1 - 0.00039 20.5 0.6 0.002 18.2 0.2 2.0 1 1 1 2 2 2 1 Bacterial transcriptional repressor C-terminal DUF2911 PF11138.8 CCF33924.1 - 0.074 12.9 0.0 0.091 12.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2911) zf-RING_2 PF13639.6 CCF33925.1 - 9.6e-13 48.2 4.3 1.5e-12 47.6 4.3 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 CCF33925.1 - 1.3e-10 40.8 1.5 2.8e-10 39.8 1.5 1.6 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 CCF33925.1 - 5.1e-07 29.4 4.1 8.3e-07 28.7 4.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CCF33925.1 - 1.1e-06 28.4 3.2 1.7e-06 27.8 3.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 CCF33925.1 - 4.1e-06 27.0 5.2 1.1e-05 25.6 5.2 1.7 1 1 0 1 1 1 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 CCF33925.1 - 1.7e-05 24.6 3.5 2.9e-05 23.8 3.5 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 CCF33925.1 - 5e-05 23.2 1.9 7.9e-05 22.5 1.9 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 CCF33925.1 - 0.0017 18.1 1.5 0.003 17.4 1.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 CCF33925.1 - 0.0031 17.5 0.8 0.006 16.6 0.8 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 CCF33925.1 - 0.0069 16.4 5.3 0.014 15.4 5.3 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING-like PF08746.11 CCF33925.1 - 0.042 14.2 2.3 0.081 13.3 2.3 1.5 1 0 0 1 1 1 0 RING-like domain zf-RING_4 PF14570.6 CCF33925.1 - 0.072 12.9 2.5 0.13 12.1 2.5 1.3 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain PHD PF00628.29 CCF33925.1 - 0.46 10.4 2.6 0.87 9.5 2.6 1.5 1 0 0 1 1 1 0 PHD-finger FANCL_C PF11793.8 CCF33925.1 - 2.4 8.4 4.7 11 6.2 3.9 2.5 2 1 0 2 2 2 0 FANCL C-terminal domain MFS_5 PF05631.14 CCF33927.1 - 7.2e-71 238.9 3.8 9.7e-71 238.5 3.8 1.1 1 0 0 1 1 1 1 Sugar-tranasporters, 12 TM MFS_1 PF07690.16 CCF33927.1 - 6.7e-23 81.2 28.4 6.7e-23 81.2 28.4 1.6 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF33927.1 - 2.8e-06 26.5 1.7 2.8e-06 26.5 1.7 3.0 1 1 2 3 3 3 2 Sugar (and other) transporter DUF2678 PF10856.8 CCF33927.1 - 3.6 7.6 8.2 1.8 8.5 0.2 3.6 2 2 1 3 3 3 0 Protein of unknown function (DUF2678) DUF805 PF05656.14 CCF33927.1 - 8.1 6.9 15.3 4.8 7.6 3.7 3.6 3 2 0 3 3 3 0 Protein of unknown function (DUF805) zf-primase PF09329.11 CCF33929.1 - 3.8e-18 65.0 1.7 6.9e-18 64.2 1.7 1.4 1 0 0 1 1 1 1 Primase zinc finger tRNA_anti-codon PF01336.25 CCF33929.1 - 0.063 13.3 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain LRS4 PF10422.9 CCF33929.1 - 2.2 7.8 6.8 0.46 10.0 1.8 2.1 2 0 0 2 2 2 0 Monopolin complex subunit LRS4 MMU163 PF17119.5 CCF33930.1 - 5.3e-73 245.2 4.7 1.8e-53 181.3 0.8 2.0 1 1 1 2 2 2 2 Mitochondrial protein up-regulated during meiosis Tom5 PF10642.9 CCF33930.1 - 0.16 12.0 0.1 0.31 11.1 0.1 1.4 1 0 0 1 1 1 0 Mitochondrial import receptor subunit or translocase F-box-like PF12937.7 CCF33931.1 - 0.11 12.4 0.3 0.42 10.6 0.0 2.1 2 0 0 2 2 2 0 F-box-like MFS_1 PF07690.16 CCF33932.1 - 5.6e-32 111.0 59.3 6.4e-29 101.0 17.6 2.5 2 1 0 3 3 3 2 Major Facilitator Superfamily TRI12 PF06609.13 CCF33932.1 - 1.8e-10 39.9 10.2 3.3e-10 39.0 10.2 1.4 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_2 PF13347.6 CCF33932.1 - 0.00085 18.0 27.6 0.0015 17.1 4.9 2.7 3 0 0 3 3 3 2 MFS/sugar transport protein VP_N-CPKC PF11475.8 CCF33932.1 - 0.049 13.5 0.8 0.093 12.6 0.8 1.5 1 0 0 1 1 1 0 Virion protein N terminal domain DUF3040 PF11239.8 CCF33932.1 - 0.092 13.0 0.3 0.092 13.0 0.3 4.6 4 1 1 5 5 5 0 Protein of unknown function (DUF3040) Rubredoxin_2 PF18073.1 CCF33932.1 - 0.16 11.7 1.4 0.5 10.1 1.4 1.9 1 0 0 1 1 1 0 Rubredoxin metal binding domain Pkinase PF00069.25 CCF33933.1 - 1.3e-26 93.6 0.0 1.7e-26 93.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF33933.1 - 8.3e-14 51.5 0.0 1.1e-13 51.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CCF33933.1 - 1.1e-06 27.7 0.0 1.5e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Peptidase_M44 PF03410.13 CCF33933.1 - 0.17 10.4 0.0 0.24 9.9 0.0 1.1 1 0 0 1 1 1 0 Metallopeptidase from vaccinia pox Peptidase_C13 PF01650.18 CCF33935.1 - 7.7e-41 140.3 0.3 1e-40 139.9 0.3 1.1 1 0 0 1 1 1 1 Peptidase C13 family MIS13 PF08202.11 CCF33935.1 - 0.016 14.5 0.1 0.023 14.0 0.1 1.2 1 0 0 1 1 1 0 Mis12-Mtw1 protein family Methyltransf_25 PF13649.6 CCF33936.1 - 4.6e-20 72.1 0.0 8.9e-20 71.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF33936.1 - 3.1e-17 63.0 0.0 5.2e-17 62.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF33936.1 - 6.4e-14 52.0 0.0 8.9e-14 51.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF33936.1 - 3.6e-12 46.9 0.0 6.5e-12 46.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF33936.1 - 1.2e-08 35.0 0.0 1.7e-08 34.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCF33936.1 - 7.1e-08 32.1 0.0 8.6e-08 31.8 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 CCF33936.1 - 4.8e-07 29.5 0.0 8.7e-07 28.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_2 PF00891.18 CCF33936.1 - 2.6e-06 26.9 0.0 3.8e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain CMAS PF02353.20 CCF33936.1 - 5.7e-06 25.8 0.0 7.5e-06 25.4 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase CheR PF01739.18 CCF33936.1 - 0.00024 20.6 0.0 0.0019 17.7 0.0 2.2 1 1 1 2 2 2 1 CheR methyltransferase, SAM binding domain Methyltransf_PK PF05891.12 CCF33936.1 - 0.00034 20.2 0.0 0.00045 19.8 0.0 1.2 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_16 PF10294.9 CCF33936.1 - 0.0036 17.1 0.0 0.0053 16.5 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase FmrO PF07091.11 CCF33936.1 - 0.0087 15.6 0.1 0.011 15.3 0.1 1.1 1 0 0 1 1 1 1 Ribosomal RNA methyltransferase (FmrO) PCMT PF01135.19 CCF33936.1 - 0.012 15.4 0.0 0.016 15.0 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TehB PF03848.14 CCF33936.1 - 0.023 14.1 0.0 0.033 13.6 0.0 1.3 1 0 0 1 1 1 0 Tellurite resistance protein TehB Laminin_G_2 PF02210.24 CCF33937.1 - 0.072 13.7 0.1 0.53 10.9 0.1 2.0 1 1 0 1 1 1 0 Laminin G domain DUF4203 PF13886.6 CCF33938.1 - 8.1e-48 162.8 28.3 1.2e-47 162.2 28.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4203) DUF4229 PF14012.6 CCF33938.1 - 6.9 6.9 7.2 10 6.3 5.6 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF4229) Glyco_hydro_3 PF00933.21 CCF33939.1 - 0.091 12.1 0.0 0.091 12.1 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 3 N terminal domain zf-C2H2_4 PF13894.6 CCF33940.1 - 0.017 15.9 0.2 3.6 8.7 0.0 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger CBP4 PF07960.11 CCF33940.1 - 1.7 8.5 11.6 3.3 7.6 11.6 1.5 1 0 0 1 1 1 0 CBP4 Asp-B-Hydro_N PF05279.11 CCF33940.1 - 4.2 7.4 12.1 6 6.9 12.1 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region V-SNARE PF05008.15 CCF33941.1 - 0.021 15.2 1.8 0.14 12.6 0.1 3.1 2 1 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus DUF4599 PF15371.6 CCF33941.1 - 0.054 14.0 0.9 0.11 13.0 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4599) Sigma70_ner PF04546.13 CCF33941.1 - 0.079 12.8 0.1 0.14 12.0 0.1 1.4 1 0 0 1 1 1 0 Sigma-70, non-essential region Fungal_lectin PF07938.12 CCF33944.1 - 8e-14 51.7 0.2 9.5e-10 38.3 0.0 2.2 1 1 1 2 2 2 2 Fungal fucose-specific lectin DUF825 PF05695.12 CCF33944.1 - 0.16 9.1 0.0 0.22 8.6 0.0 1.0 1 0 0 1 1 1 0 Plant protein of unknown function (DUF825) KR PF08659.10 CCF33946.1 - 5.9e-20 71.9 0.0 9.3e-20 71.3 0.0 1.3 1 0 0 1 1 1 1 KR domain ADH_zinc_N_2 PF13602.6 CCF33946.1 - 1.5e-09 39.0 0.0 2.4e-09 38.3 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 CCF33946.1 - 3.7e-05 23.7 0.0 6.4e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase adh_short PF00106.25 CCF33946.1 - 0.073 12.5 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 short chain dehydrogenase AAA PF00004.29 CCF33947.1 - 8.5e-17 61.8 0.0 1.9e-16 60.7 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CCF33947.1 - 0.00025 21.5 0.1 0.0012 19.2 0.1 2.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 CCF33947.1 - 0.0022 18.3 4.0 0.036 14.4 0.1 3.9 3 1 1 4 4 4 1 AAA domain ATPase PF06745.13 CCF33947.1 - 0.0074 15.7 0.4 0.017 14.5 0.4 1.6 1 0 0 1 1 1 1 KaiC PRD PF00874.20 CCF33947.1 - 0.021 15.1 1.5 5.4 7.4 0.3 2.5 2 0 0 2 2 2 0 PRD domain AAA_30 PF13604.6 CCF33947.1 - 0.029 14.1 0.1 0.087 12.5 0.1 1.8 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 CCF33947.1 - 0.042 13.9 0.0 0.12 12.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 CCF33947.1 - 0.069 12.8 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_33 PF13671.6 CCF33947.1 - 0.11 12.7 0.0 0.34 11.1 0.0 1.9 1 0 0 1 1 1 0 AAA domain NmrA PF05368.13 CCF33948.1 - 2.5e-21 76.3 0.0 3.6e-21 75.8 0.0 1.3 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CCF33948.1 - 7.8e-15 55.2 0.0 1.7e-14 54.1 0.0 1.6 1 1 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 CCF33948.1 - 0.068 12.2 0.0 0.13 11.2 0.0 1.5 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Caps_synth PF05704.12 CCF33952.1 - 3.9e-16 59.3 0.5 5.4e-16 58.8 0.5 1.2 1 0 0 1 1 1 1 Capsular polysaccharide synthesis protein Gly_transf_sug PF04488.15 CCF33952.1 - 3.3e-05 24.4 0.0 5.4e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif TcdA_TcdB PF12919.7 CCF33952.1 - 0.2 10.9 0.0 0.31 10.3 0.0 1.2 1 0 0 1 1 1 0 TcdA/TcdB catalytic glycosyltransferase domain DUF1768 PF08719.11 CCF33953.1 - 3.2e-52 177.0 0.0 3.7e-52 176.8 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) GET2 PF08690.10 CCF33954.1 - 3.6e-46 158.2 0.0 4.9e-46 157.8 0.0 1.1 1 0 0 1 1 1 1 GET complex subunit GET2 SRA1 PF07304.11 CCF33955.1 - 1.5e-08 34.5 10.3 1.5e-08 34.5 10.3 2.6 1 1 1 2 2 2 1 Steroid receptor RNA activator (SRA1) Prp18 PF02840.15 CCF33955.1 - 0.00089 19.3 0.3 0.004 17.2 0.2 1.9 1 1 1 2 2 2 1 Prp18 domain ABC_tran PF00005.27 CCF33956.1 - 4.6e-46 156.7 0.0 9.5e-27 94.2 0.0 2.8 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 CCF33956.1 - 2.6e-31 109.3 37.1 4.5e-25 88.8 14.7 2.6 3 0 0 3 3 3 2 ABC transporter transmembrane region AAA_21 PF13304.6 CCF33956.1 - 1.5e-09 38.1 0.6 0.083 12.7 0.3 4.0 2 2 2 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CCF33956.1 - 2.7e-09 36.8 9.5 0.011 15.1 0.0 4.7 4 1 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CCF33956.1 - 5.6e-07 29.2 0.6 0.0037 17.0 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.18 CCF33956.1 - 3.7e-06 26.5 0.3 0.069 12.5 0.1 2.3 2 0 0 2 2 2 2 FtsK/SpoIIIE family AAA_22 PF13401.6 CCF33956.1 - 2.1e-05 24.8 0.0 0.015 15.6 0.0 2.7 2 1 0 2 2 2 1 AAA domain SbcCD_C PF13558.6 CCF33956.1 - 4.2e-05 23.7 0.4 0.51 10.6 0.1 3.0 2 1 0 2 2 2 2 Putative exonuclease SbcCD, C subunit RsgA_GTPase PF03193.16 CCF33956.1 - 5.8e-05 23.1 0.5 0.28 11.1 0.3 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_23 PF13476.6 CCF33956.1 - 0.00054 20.5 0.0 0.48 10.9 0.0 2.3 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 CCF33956.1 - 0.00077 19.5 0.0 1 9.5 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase cobW PF02492.19 CCF33956.1 - 0.0023 17.6 0.9 1.6 8.3 0.1 2.4 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain AAA_16 PF13191.6 CCF33956.1 - 0.0027 18.1 0.0 3.9 7.8 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain AAA_15 PF13175.6 CCF33956.1 - 0.0037 17.0 0.0 0.91 9.2 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_7 PF12775.7 CCF33956.1 - 0.0041 16.7 0.2 0.25 10.8 0.1 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_25 PF13481.6 CCF33956.1 - 0.0062 16.1 4.3 2.3 7.8 0.6 3.7 3 1 0 3 3 3 2 AAA domain Dynamin_N PF00350.23 CCF33956.1 - 0.0074 16.4 5.4 0.013 15.6 0.1 2.6 3 0 0 3 3 2 1 Dynamin family T2SSE PF00437.20 CCF33956.1 - 0.0074 15.4 0.0 0.7 8.9 0.0 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein Roc PF08477.13 CCF33956.1 - 0.029 14.6 0.2 0.89 9.8 0.0 3.0 3 0 0 3 3 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_33 PF13671.6 CCF33956.1 - 0.03 14.5 0.3 8.2 6.6 0.0 2.8 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 CCF33956.1 - 0.031 14.2 0.0 6 6.8 0.0 2.7 2 0 0 2 2 2 0 NACHT domain Pox_A32 PF04665.12 CCF33956.1 - 0.037 13.5 0.3 0.7 9.3 0.0 2.4 2 0 0 2 2 2 0 Poxvirus A32 protein DUF87 PF01935.17 CCF33956.1 - 0.039 14.0 1.7 0.98 9.5 0.4 2.5 2 0 0 2 2 2 0 Helicase HerA, central domain IstB_IS21 PF01695.17 CCF33956.1 - 0.044 13.5 1.2 13 5.5 0.1 3.4 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_24 PF13479.6 CCF33956.1 - 0.051 13.3 0.0 1.9 8.2 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 CCF33956.1 - 0.071 12.8 1.8 9.4 5.9 0.0 3.2 2 1 0 2 2 2 0 AAA domain ATP_bind_1 PF03029.17 CCF33956.1 - 0.12 12.2 2.6 7 6.4 0.1 3.1 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein NTPase_1 PF03266.15 CCF33956.1 - 0.19 11.6 1.4 1.3 9.0 0.0 2.7 3 0 0 3 3 3 0 NTPase AAA PF00004.29 CCF33956.1 - 0.21 12.0 0.9 12 6.4 0.1 3.2 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Septin PF00735.18 CCF33956.1 - 0.22 10.8 0.3 0.84 8.9 0.0 1.9 2 0 0 2 2 2 0 Septin PIG-L PF02585.17 CCF33957.1 - 1.3e-25 90.5 0.0 2.1e-25 89.8 0.0 1.3 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase AGH PF17558.2 CCF33957.1 - 0.22 11.7 0.1 0.58 10.3 0.0 1.7 2 0 0 2 2 2 0 Androgenic gland hormone ATP13 PF12921.7 CCF33958.1 - 3.7e-14 52.6 1.9 4.4e-14 52.3 0.1 2.0 2 0 0 2 2 2 1 Mitochondrial ATPase expression LSM PF01423.22 CCF33959.1 - 6.6e-15 54.5 0.2 8.5e-15 54.2 0.2 1.1 1 0 0 1 1 1 1 LSM domain DUF755 PF05501.11 CCF33961.1 - 0.021 15.1 15.8 0.026 14.8 15.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF755) SR-25 PF10500.9 CCF33961.1 - 0.028 14.0 12.8 0.033 13.8 12.8 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein AP3D1 PF06375.11 CCF33961.1 - 1.5 9.1 9.4 1.7 8.9 9.4 1.1 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 PNP_UDP_1 PF01048.20 CCF33962.1 - 4.2e-06 26.2 0.0 4.9e-06 26.0 0.0 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily NACHT PF05729.12 CCF33963.1 - 0.00034 20.6 0.0 0.0022 18.0 0.0 2.1 2 0 0 2 2 2 1 NACHT domain AAA_22 PF13401.6 CCF33963.1 - 0.009 16.3 0.0 0.025 14.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain Glyco_hydro_3_C PF01915.22 CCF33963.1 - 0.058 13.3 0.0 0.095 12.6 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 3 C-terminal domain AAA_16 PF13191.6 CCF33963.1 - 0.06 13.7 1.7 1.4 9.2 1.7 2.6 1 1 0 1 1 1 0 AAA ATPase domain MFS_1 PF07690.16 CCF33964.1 - 3.5e-08 32.8 17.2 3.5e-08 32.8 17.2 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily CPP1-like PF11833.8 CCF33964.1 - 0.16 11.6 1.2 0.29 10.8 1.2 1.5 1 0 0 1 1 1 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like DUF4395 PF14340.6 CCF33964.1 - 1.9 8.8 11.7 3.8 7.9 8.5 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4395) Peptidase_M48_N PF16491.5 CCF33964.1 - 2.2 8.2 8.0 0.38 10.6 0.1 2.7 2 1 1 3 3 3 0 CAAX prenyl protease N-terminal, five membrane helices Methyltransf_15 PF09445.10 CCF33966.1 - 4.8e-46 156.4 0.0 6.3e-46 156.0 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Met_10 PF02475.16 CCF33966.1 - 3e-05 23.9 0.0 3.3e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Cons_hypoth95 PF03602.15 CCF33966.1 - 0.00039 20.1 0.0 0.00063 19.4 0.0 1.4 1 0 0 1 1 1 1 Conserved hypothetical protein 95 UPF0020 PF01170.18 CCF33966.1 - 0.031 14.0 0.0 0.084 12.6 0.0 1.7 1 1 0 1 1 1 0 Putative RNA methylase family UPF0020 Methyltransf_25 PF13649.6 CCF33966.1 - 0.095 13.4 0.0 0.23 12.2 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.12 CCF33966.1 - 0.1 13.2 0.0 0.24 12.1 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_5 PF01795.19 CCF33966.1 - 0.16 11.4 0.0 0.22 11.0 0.0 1.1 1 0 0 1 1 1 0 MraW methylase family Dopey_N PF04118.14 CCF33967.1 - 3.9e-15 55.8 0.1 1.3e-14 54.0 0.0 1.9 2 0 0 2 2 2 1 Dopey, N-terminal 4HBT_2 PF13279.6 CCF33969.1 - 6.6e-22 78.3 0.0 1.1e-21 77.6 0.0 1.3 1 0 0 1 1 1 1 Thioesterase-like superfamily 4HBT PF03061.22 CCF33969.1 - 0.016 15.5 0.0 0.048 14.0 0.0 1.8 2 0 0 2 2 2 0 Thioesterase superfamily CoA_transf_3 PF02515.17 CCF33970.1 - 2.1e-110 369.4 0.0 2.3e-110 369.2 0.0 1.0 1 0 0 1 1 1 1 CoA-transferase family III Acyl-CoA_dh_1 PF00441.24 CCF33971.1 - 2.3e-30 105.8 1.9 4.1e-30 105.0 1.9 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 CCF33971.1 - 3e-20 72.2 0.0 5.4e-20 71.4 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 CCF33971.1 - 5.9e-20 72.0 0.1 1.2e-19 71.0 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 CCF33971.1 - 6.4e-15 55.6 5.4 6.5e-15 55.6 3.6 1.9 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Sugar_tr PF00083.24 CCF33972.1 - 1e-44 153.2 6.2 1.1e-44 153.0 6.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF33972.1 - 2.6e-08 33.2 18.8 2.7e-08 33.1 18.0 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily NUSAP PF16006.5 CCF33973.1 - 0.062 13.1 3.9 0.1 12.4 3.9 1.3 1 0 0 1 1 1 0 Nucleolar and spindle-associated protein PAN_4 PF14295.6 CCF33973.1 - 0.98 9.4 8.4 0.32 10.9 0.8 2.9 2 1 0 2 2 2 0 PAN domain Tubulin PF00091.25 CCF33974.1 - 1.7e-27 97.0 0.0 1.8e-27 96.8 0.0 1.0 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain APH PF01636.23 CCF33975.1 - 1.8e-10 41.2 0.0 2.3e-10 40.8 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CCF33975.1 - 6.5e-08 32.4 0.1 9.4e-08 31.9 0.1 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase EcKinase PF02958.20 CCF33975.1 - 6.7e-07 28.9 0.0 9.9e-07 28.3 0.0 1.2 1 0 0 1 1 1 1 Ecdysteroid kinase Kdo PF06293.14 CCF33975.1 - 0.0017 17.7 0.1 0.092 12.1 0.0 2.3 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Fructosamin_kin PF03881.14 CCF33975.1 - 0.049 12.8 0.0 0.085 12.0 0.0 1.3 1 0 0 1 1 1 0 Fructosamine kinase DUF1679 PF07914.11 CCF33975.1 - 0.17 10.7 0.0 0.23 10.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) CTU2 PF10288.9 CCF33976.1 - 1.3e-13 51.2 0.1 1.3e-11 44.7 0.1 2.7 1 1 0 1 1 1 1 Cytoplasmic tRNA 2-thiolation protein 2 zf-FPG_IleRS PF06827.14 CCF33976.1 - 3.2 7.7 8.4 3.1 7.7 5.8 2.2 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS Mito_carr PF00153.27 CCF33977.1 - 3.9e-12 45.9 0.0 4.8e-12 45.6 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial carrier protein Lgl_C PF08596.10 CCF33978.1 - 8.9e-115 383.5 0.0 2.8e-114 381.9 0.0 1.8 2 0 0 2 2 2 1 Lethal giant larvae(Lgl) like, C-terminal ANAPC4_WD40 PF12894.7 CCF33978.1 - 1.5e-05 25.2 0.0 0.45 10.9 0.0 4.7 3 2 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CCF33978.1 - 3.1e-05 24.6 1.2 0.033 15.1 0.0 4.5 5 0 0 5 5 5 1 WD domain, G-beta repeat HsdM_N PF12161.8 CCF33979.1 - 0.014 16.0 0.3 0.74 10.4 0.0 2.1 2 0 0 2 2 2 0 HsdM N-terminal domain DUF4446 PF14584.6 CCF33979.1 - 0.038 14.0 0.1 0.071 13.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) DUF3377 PF11857.8 CCF33979.1 - 0.54 10.2 0.1 0.54 10.2 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3377) PAP1 PF08601.10 CCF33982.1 - 1e-85 288.7 51.5 1.1e-61 209.6 5.7 4.3 1 1 2 4 4 4 3 Transcription factor PAP1 bZIP_1 PF00170.21 CCF33982.1 - 1.4e-09 37.9 12.7 3.2e-09 36.8 12.7 1.6 1 0 0 1 1 1 1 bZIP transcription factor SlyX PF04102.12 CCF33982.1 - 0.0024 18.4 1.2 0.0067 17.0 1.2 1.7 1 0 0 1 1 1 1 SlyX DUF812 PF05667.11 CCF33982.1 - 0.0032 16.4 4.3 0.0043 16.0 4.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF812) SHE3 PF17078.5 CCF33982.1 - 0.0059 16.3 7.4 0.0059 16.3 7.4 1.7 2 0 0 2 2 2 1 SWI5-dependent HO expression protein 3 bZIP_2 PF07716.15 CCF33982.1 - 0.0071 16.4 13.1 0.035 14.2 13.1 2.0 1 1 0 1 1 1 1 Basic region leucine zipper APG6_N PF17675.1 CCF33982.1 - 0.0073 16.8 5.8 0.015 15.8 5.8 1.5 1 0 0 1 1 1 1 Apg6 coiled-coil region TolA_bind_tri PF16331.5 CCF33982.1 - 0.018 15.1 1.0 0.043 13.9 1.0 1.6 1 0 0 1 1 1 0 TolA binding protein trimerisation Helo_like_N PF17111.5 CCF33982.1 - 0.075 12.4 0.9 0.16 11.3 0.9 1.4 1 0 0 1 1 1 0 Fungal N-terminal domain of STAND proteins DOG1 PF14144.6 CCF33982.1 - 0.087 13.1 0.4 0.2 11.9 0.4 1.6 1 0 0 1 1 1 0 Seed dormancy control DUF4407 PF14362.6 CCF33982.1 - 0.09 12.1 2.8 0.14 11.5 2.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) dsrm PF00035.26 CCF33982.1 - 0.091 13.5 0.0 0.27 11.9 0.0 1.8 1 0 0 1 1 1 0 Double-stranded RNA binding motif bZIP_Maf PF03131.17 CCF33982.1 - 0.092 13.3 8.8 0.2 12.2 8.8 1.5 1 0 0 1 1 1 0 bZIP Maf transcription factor PspA_IM30 PF04012.12 CCF33982.1 - 0.12 12.0 9.1 0.22 11.1 9.1 1.4 1 0 0 1 1 1 0 PspA/IM30 family YabA PF06156.13 CCF33982.1 - 0.24 12.1 2.2 0.62 10.7 2.2 1.6 1 0 0 1 1 1 0 Initiation control protein YabA MCU PF04678.13 CCF33982.1 - 0.25 11.4 2.0 0.47 10.5 2.0 1.3 1 0 0 1 1 1 0 Mitochondrial calcium uniporter XhlA PF10779.9 CCF33982.1 - 0.3 11.3 4.4 0.64 10.3 4.4 1.5 1 0 0 1 1 1 0 Haemolysin XhlA UPF0242 PF06785.11 CCF33982.1 - 0.47 10.5 6.1 0.89 9.6 6.1 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus TMCO5 PF14992.6 CCF33982.1 - 0.48 10.0 4.9 0.95 9.0 4.9 1.4 1 0 0 1 1 1 0 TMCO5 family Atg14 PF10186.9 CCF33982.1 - 0.48 9.5 5.5 0.84 8.7 5.5 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 FlaC_arch PF05377.11 CCF33982.1 - 0.55 10.7 2.3 1.2 9.6 2.3 1.6 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) V_ATPase_I PF01496.19 CCF33982.1 - 1.2 6.9 3.0 1.9 6.3 3.0 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Prefoldin_2 PF01920.20 CCF33982.1 - 1.8 8.5 8.6 0.99 9.4 5.6 2.0 2 0 0 2 2 2 0 Prefoldin subunit Jnk-SapK_ap_N PF09744.9 CCF33982.1 - 2.1 8.5 9.1 4.4 7.5 9.1 1.4 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Spc24 PF08286.11 CCF33982.1 - 2.6 8.3 5.4 15 5.9 5.4 2.3 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 LAP1C PF05609.12 CCF33982.1 - 2.6 7.1 11.7 5.6 5.9 11.7 1.5 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) GREB1 PF15782.5 CCF33982.1 - 2.7 5.0 6.3 3.6 4.6 6.3 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Nop53 PF07767.11 CCF33982.1 - 4 6.7 20.7 6.3 6.1 20.7 1.2 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Snapin_Pallidin PF14712.6 CCF33982.1 - 8.4 6.9 8.6 0.31 11.5 1.5 2.2 3 0 0 3 3 2 0 Snapin/Pallidin Sugar_tr PF00083.24 CCF33983.1 - 1.3e-121 406.6 18.1 1.5e-121 406.4 18.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF33983.1 - 2.5e-24 85.9 57.7 1.6e-22 80.0 27.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Abhydrolase_4 PF08386.10 CCF33984.1 - 4.8e-12 45.9 0.0 9.4e-12 45.0 0.0 1.5 1 0 0 1 1 1 1 TAP-like protein Abhydrolase_1 PF00561.20 CCF33984.1 - 8.1e-09 35.5 0.0 1.3e-08 34.8 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Fungal_trans PF04082.18 CCF33985.1 - 2.7e-12 46.3 0.0 4.7e-12 45.5 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF33985.1 - 7.1e-08 32.4 7.1 1.3e-07 31.6 7.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CGI-121 PF08617.10 CCF33986.1 - 1.3e-54 184.7 0.0 1.5e-54 184.5 0.0 1.0 1 0 0 1 1 1 1 Kinase binding protein CGI-121 DUF2860 PF11059.8 CCF33986.1 - 0.12 11.5 0.0 0.16 11.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2860) Pro_dh PF01619.18 CCF33987.1 - 7.6e-73 245.6 0.0 8.9e-73 245.4 0.0 1.0 1 0 0 1 1 1 1 Proline dehydrogenase Serglycin PF04360.12 CCF33988.1 - 4.6 7.2 9.1 0.14 12.1 2.3 1.8 2 0 0 2 2 2 0 Serglycin UDPGT PF00201.18 CCF33989.1 - 4.2e-09 35.7 0.0 5.5e-09 35.4 0.0 1.1 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Ribosomal_L36e PF01158.18 CCF33989.1 - 0.023 14.9 0.0 0.038 14.2 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L36e Abhydrolase_1 PF00561.20 CCF33990.1 - 3.8e-24 85.7 0.2 6.4e-23 81.7 0.2 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCF33990.1 - 2.1e-17 64.5 2.6 3e-17 64.0 2.6 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCF33990.1 - 1.1e-13 51.0 0.0 4.6e-13 49.0 0.0 1.8 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.14 CCF33990.1 - 0.18 10.5 0.0 0.27 9.9 0.0 1.3 1 0 0 1 1 1 0 Ndr family Cys_Met_Meta_PP PF01053.20 CCF33991.1 - 3.6e-150 499.8 0.0 4.1e-150 499.6 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 CCF33991.1 - 9.8e-13 48.1 0.3 1.7e-12 47.3 0.3 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.21 CCF33991.1 - 1.1e-10 41.2 0.0 1.9e-10 40.5 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 CCF33991.1 - 2.2e-08 33.5 0.6 5.5e-08 32.2 0.6 1.6 1 1 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 CCF33991.1 - 1.2e-07 31.4 0.0 2.6e-07 30.2 0.0 1.4 1 1 0 1 1 1 1 Beta-eliminating lyase Met_gamma_lyase PF06838.11 CCF33991.1 - 0.00017 20.3 0.1 0.00021 19.9 0.1 1.2 1 0 0 1 1 1 1 Methionine gamma-lyase SepSecS PF05889.13 CCF33991.1 - 0.011 14.5 0.0 0.015 14.0 0.0 1.1 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Ribosomal_60s PF00428.19 CCF33991.1 - 0.062 13.9 0.4 0.062 13.9 0.4 2.1 2 0 0 2 2 2 0 60s Acidic ribosomal protein GDC-P PF02347.16 CCF33991.1 - 0.12 11.1 0.0 0.18 10.6 0.0 1.1 1 0 0 1 1 1 0 Glycine cleavage system P-protein CPSase_L_D2 PF02786.17 CCF33991.1 - 0.13 11.8 0.0 0.25 10.8 0.0 1.4 1 0 0 1 1 1 0 Carbamoyl-phosphate synthase L chain, ATP binding domain DUF2012 PF09430.10 CCF33992.1 - 2.7e-20 72.7 0.0 4.1e-20 72.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2012) G6PD_C PF02781.16 CCF33996.1 - 5.9e-107 357.2 0.0 7.9e-107 356.8 0.0 1.0 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain Med14 PF08638.11 CCF33997.1 - 3.1e-67 225.7 0.0 6.4e-67 224.7 0.0 1.5 1 0 0 1 1 1 1 Mediator complex subunit MED14 Oxysterol_BP PF01237.18 CCF33999.1 - 1.2e-89 300.8 0.3 3.9e-87 292.5 0.3 2.0 1 1 0 1 1 1 1 Oxysterol-binding protein zf-CCCH PF00642.24 CCF34000.1 - 1.2e-08 34.6 18.6 5.3e-07 29.4 2.6 3.2 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 CCF34000.1 - 0.0058 17.3 3.1 0.4 11.4 0.2 2.4 2 0 0 2 2 2 2 Torus domain zf_CCCH_4 PF18345.1 CCF34000.1 - 0.012 15.6 2.9 0.012 15.6 2.9 3.3 3 0 0 3 3 3 0 Zinc finger domain RRM_1 PF00076.22 CCF34000.1 - 0.014 15.2 0.0 0.021 14.6 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH_3 PF15663.5 CCF34000.1 - 0.057 13.6 1.8 0.37 11.0 0.1 2.3 2 0 0 2 2 2 0 Zinc-finger containing family Lactonase PF10282.9 CCF34002.1 - 2e-87 293.7 0.0 2.4e-87 293.4 0.0 1.0 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller HECW_N PF16562.5 CCF34003.1 - 0.0015 18.4 0.0 0.0031 17.3 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2 PEMT PF04191.13 CCF34003.1 - 0.0053 17.1 0.0 0.0091 16.4 0.0 1.3 1 0 0 1 1 1 1 Phospholipid methyltransferase SKICH PF17751.1 CCF34003.1 - 0.037 14.6 0.1 0.79 10.3 0.1 2.2 1 1 0 1 1 1 0 SKICH domain Adaptin_binding PF10199.9 CCF34004.1 - 2.9e-15 56.9 4.8 4.7e-15 56.3 4.8 1.3 1 0 0 1 1 1 1 Alpha and gamma adaptin binding protein p34 Alpha_GJ PF03229.13 CCF34004.1 - 0.051 14.1 4.1 0.11 13.1 4.1 1.5 1 0 0 1 1 1 0 Alphavirus glycoprotein J Herpes_U47 PF05467.11 CCF34004.1 - 0.057 11.6 3.3 0.077 11.1 3.3 1.1 1 0 0 1 1 1 0 Herpesvirus glycoprotein U47 Esterase_phd PF10503.9 CCF34006.1 - 2.2e-22 79.7 0.2 2.9e-22 79.3 0.2 1.1 1 0 0 1 1 1 1 Esterase PHB depolymerase Peptidase_S9 PF00326.21 CCF34006.1 - 1.2e-09 38.0 0.8 1.6e-09 37.6 0.8 1.1 1 0 0 1 1 1 1 Prolyl oligopeptidase family Esterase PF00756.20 CCF34006.1 - 0.00048 19.8 0.5 0.00071 19.3 0.5 1.2 1 0 0 1 1 1 1 Putative esterase Peptidase_S10 PF00450.22 CCF34006.1 - 0.00056 19.4 0.4 0.0011 18.4 0.2 1.4 1 1 0 1 1 1 1 Serine carboxypeptidase COesterase PF00135.28 CCF34006.1 - 0.0046 15.9 0.6 0.12 11.2 0.1 2.1 2 0 0 2 2 2 1 Carboxylesterase family BAAT_C PF08840.11 CCF34006.1 - 0.0066 16.4 0.1 0.01 15.7 0.1 1.3 1 0 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal DLH PF01738.18 CCF34006.1 - 0.011 15.3 0.7 0.018 14.6 0.3 1.6 2 0 0 2 2 2 0 Dienelactone hydrolase family Abhydrolase_1 PF00561.20 CCF34006.1 - 0.021 14.5 1.2 0.038 13.6 0.7 1.5 1 1 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 CCF34006.1 - 0.03 14.1 0.1 0.082 12.7 0.0 1.7 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 CCF34006.1 - 0.045 13.0 0.0 0.13 11.5 0.0 1.6 1 1 1 2 2 2 0 Serine aminopeptidase, S33 AAA_14 PF13173.6 CCF34006.1 - 0.14 12.2 0.0 0.22 11.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain adh_short_C2 PF13561.6 CCF34007.1 - 2.3e-34 119.0 0.3 3.3e-34 118.5 0.3 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF34007.1 - 9.6e-24 83.9 0.7 1.5e-23 83.3 0.7 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF34007.1 - 0.001 19.0 1.1 0.0023 17.9 1.1 1.5 1 1 0 1 1 1 1 KR domain ECH_1 PF00378.20 CCF34008.1 - 3.3e-23 82.3 0.0 5e-23 81.7 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CCF34008.1 - 3.9e-11 43.0 0.0 4.5e-11 42.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase adh_short_C2 PF13561.6 CCF34009.1 - 5.4e-59 199.6 1.7 6.3e-59 199.4 1.7 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF34009.1 - 2.2e-42 144.7 1.8 2.7e-42 144.4 1.8 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF34009.1 - 5.6e-15 55.7 0.5 7.8e-15 55.2 0.5 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF34009.1 - 0.0054 16.2 0.3 0.021 14.3 0.3 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CCF34009.1 - 0.034 13.6 0.1 0.19 11.1 0.0 1.9 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase DUF134 PF02001.16 CCF34009.1 - 0.068 13.7 0.1 0.16 12.5 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function DUF134 Colicin PF01024.19 CCF34010.1 - 0.12 12.3 0.2 0.24 11.3 0.1 1.5 2 0 0 2 2 2 0 Colicin pore forming domain Alpha-L-AF_C PF06964.12 CCF34011.1 - 5.7e-20 72.1 0.0 1.1e-19 71.1 0.0 1.5 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase C-terminal domain ADH_zinc_N PF00107.26 CCF34012.1 - 5.9e-26 91.0 1.1 1.1e-25 90.2 1.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCF34012.1 - 7.3e-17 62.7 0.1 2.3e-16 61.1 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCF34012.1 - 2.9e-11 43.2 0.1 8.6e-11 41.7 0.1 1.8 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain TrkA_N PF02254.18 CCF34012.1 - 0.001 19.3 0.0 0.0022 18.3 0.0 1.6 1 0 0 1 1 1 1 TrkA-N domain AlaDh_PNT_C PF01262.21 CCF34012.1 - 0.033 13.5 0.5 0.054 12.8 0.5 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Mito_carr PF00153.27 CCF34014.1 - 5.1e-51 170.6 5.9 1.7e-21 76.0 0.3 4.0 4 0 0 4 4 4 4 Mitochondrial carrier protein DND1_DSRM PF14709.7 CCF34014.1 - 0.083 13.1 0.0 0.16 12.3 0.0 1.4 1 0 0 1 1 1 0 double strand RNA binding domain from DEAD END PROTEIN 1 DUF2370 PF10176.9 CCF34016.1 - 3.9e-90 301.4 0.6 1.1e-89 300.0 0.0 1.9 1 1 0 2 2 2 1 Protein of unknown function (DUF2370) PCMT PF01135.19 CCF34017.1 - 6.6e-55 186.1 0.0 8.5e-55 185.8 0.0 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 CCF34017.1 - 1.9e-05 24.5 0.0 3.4e-05 23.7 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 CCF34017.1 - 0.00028 20.9 0.0 0.00044 20.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF34017.1 - 0.0014 19.3 0.0 0.003 18.2 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CCF34017.1 - 0.016 14.7 0.0 0.027 14.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_23 PF13489.6 CCF34017.1 - 0.045 13.6 0.0 0.057 13.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Ubie_methyltran PF01209.18 CCF34017.1 - 0.079 12.3 0.0 0.14 11.5 0.0 1.4 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family RrnaAD PF00398.20 CCF34017.1 - 0.1 11.6 0.0 0.15 11.1 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Methyltransf_11 PF08241.12 CCF34017.1 - 0.11 13.2 0.0 0.2 12.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain MetW PF07021.12 CCF34017.1 - 0.22 11.1 0.0 0.36 10.4 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW COesterase PF00135.28 CCF34018.1 - 1.5e-69 235.2 0.0 5.5e-69 233.4 0.0 1.7 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CCF34018.1 - 7e-07 29.3 0.3 9.3e-06 25.6 0.3 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CCF34018.1 - 0.17 11.3 0.9 0.28 10.6 0.1 1.7 2 0 0 2 2 2 0 Prolyl oligopeptidase family FAD_binding_4 PF01565.23 CCF34019.1 - 1.5e-22 79.8 0.0 2.5e-22 79.1 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 CCF34019.1 - 0.00062 19.8 0.2 0.0014 18.7 0.2 1.6 1 0 0 1 1 1 1 Berberine and berberine like Sortilin-Vps10 PF15902.5 CCF34020.1 - 8.6e-09 34.7 0.1 1.4e-07 30.7 0.0 2.2 2 0 0 2 2 2 1 Sortilin, neurotensin receptor 3, BNR_6 PF15899.5 CCF34020.1 - 0.0007 19.4 0.7 0.92 9.7 0.0 4.5 5 0 0 5 5 5 1 BNR-Asp box repeat BNR PF02012.20 CCF34020.1 - 0.0067 16.2 7.6 18 5.9 0.0 5.4 6 0 0 6 6 6 2 BNR/Asp-box repeat PUD PF03714.14 CCF34020.1 - 0.092 13.6 1.3 0.3 12.0 0.2 2.3 2 1 0 2 2 2 0 Bacterial pullanase-associated domain GspH PF12019.8 CCF34020.1 - 1.6 9.2 7.4 0.1 13.1 1.3 2.1 2 1 0 2 2 2 0 Type II transport protein GspH NPR2 PF06218.11 CCF34021.1 - 1.3e-69 235.1 0.0 9.9e-49 166.3 0.0 2.0 1 1 1 2 2 2 2 Nitrogen permease regulator 2 tRNA-synt_1b PF00579.25 CCF34022.1 - 2.9e-79 266.5 0.0 3.9e-79 266.0 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) TyrRSs_C PF16714.5 CCF34022.1 - 9.7e-47 157.7 0.0 4.5e-46 155.6 0.0 2.0 2 0 0 2 2 2 1 Tyrosyl-tRNA synthetase C-terminal domain APT PF03440.14 CCF34022.1 - 0.15 12.1 0.2 4.1 7.4 0.0 2.5 2 0 0 2 2 2 0 Aerolysin/Pertussis toxin (APT) domain CybS PF05328.12 CCF34023.1 - 4.7e-48 162.3 0.0 6e-48 161.9 0.0 1.1 1 0 0 1 1 1 1 CybS, succinate dehydrogenase cytochrome B small subunit DUF3419 PF11899.8 CCF34024.1 - 1.1e-163 545.0 0.0 1.4e-163 544.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3419) Methyltransf_23 PF13489.6 CCF34024.1 - 2.2e-14 53.6 0.0 1.3e-12 47.9 0.0 2.9 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF34024.1 - 1.1e-09 38.9 0.0 1e-06 29.3 0.0 3.8 4 0 0 4 4 4 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF34024.1 - 1.1e-08 35.8 0.0 7.2e-08 33.1 0.0 2.4 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF34024.1 - 2e-08 34.8 0.0 3.7e-05 24.3 0.0 4.0 4 0 0 4 4 4 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCF34024.1 - 4.4e-07 29.5 0.0 0.0017 17.7 0.0 2.7 3 0 0 3 3 3 2 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 CCF34024.1 - 4.7e-07 29.7 0.0 1.2e-05 25.2 0.0 2.5 2 1 0 2 2 2 1 Methyltransferase domain PCMT PF01135.19 CCF34024.1 - 0.00082 19.2 0.0 0.0021 17.9 0.0 1.6 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_4 PF02390.17 CCF34024.1 - 0.19 11.2 0.0 2.6 7.5 0.0 2.6 3 0 0 3 3 3 0 Putative methyltransferase Hydrolase PF00702.26 CCF34025.1 - 0.00087 19.6 0.0 0.0036 17.6 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Tachystatin_B PF11478.8 CCF34025.1 - 0.033 14.1 1.8 0.044 13.7 0.3 2.0 2 0 0 2 2 2 0 Antimicrobial chitin binding protein tachystatin B HAD_2 PF13419.6 CCF34025.1 - 0.063 13.4 0.0 0.082 13.0 0.0 1.2 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Aminotran_3 PF00202.21 CCF34026.1 - 1.2e-119 399.6 0.0 1.4e-119 399.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 CCF34026.1 - 0.05 12.8 0.0 0.071 12.3 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class I and II Aldedh PF00171.22 CCF34027.1 - 3.2e-161 536.9 0.1 3.6e-161 536.8 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 CCF34027.1 - 0.04 13.4 0.0 3.6 7.0 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1487) EMC1_C PF07774.13 CCF34028.1 - 1.3e-77 260.3 0.0 2e-77 259.6 0.0 1.3 1 0 0 1 1 1 1 ER membrane protein complex subunit 1, C-terminal PQQ_2 PF13360.6 CCF34028.1 - 4.2e-20 72.3 12.1 7.3e-19 68.3 2.7 2.8 3 0 0 3 3 3 2 PQQ-like domain PQQ PF01011.21 CCF34028.1 - 0.016 15.1 1.1 12 6.1 0.0 4.4 3 0 0 3 3 3 0 PQQ enzyme repeat Isy1 PF06246.12 CCF34029.1 - 1.4e-91 306.6 0.7 1.6e-91 306.4 0.7 1.0 1 0 0 1 1 1 1 Isy1-like splicing family Ribosomal_S14 PF00253.21 CCF34030.1 - 2.9e-20 71.7 1.3 5.6e-20 70.9 1.3 1.5 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e DUF604 PF04646.12 CCF34031.1 - 7.9e-09 35.3 0.0 2e-07 30.7 0.0 2.2 1 1 0 1 1 1 1 Protein of unknown function, DUF604 Fringe PF02434.16 CCF34031.1 - 6.2e-07 29.1 0.0 1.2e-06 28.1 0.0 1.6 1 1 0 1 1 1 1 Fringe-like BRO1 PF03097.18 CCF34032.1 - 5.5e-120 400.8 0.0 8.3e-120 400.2 0.0 1.3 1 0 0 1 1 1 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 CCF34032.1 - 2.2e-84 283.2 3.0 2.2e-84 283.2 3.0 1.6 2 0 0 2 2 2 1 ALIX V-shaped domain binding to HIV UPF0242 PF06785.11 CCF34032.1 - 0.65 10.1 5.2 7.9 6.5 4.2 2.6 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus FAM70 PF14967.6 CCF34032.1 - 1.2 8.5 5.2 2 7.8 5.2 1.3 1 0 0 1 1 1 0 FAM70 protein Seryl_tRNA_N PF02403.22 CCF34032.1 - 1.7 8.9 8.7 1.2 9.4 1.9 3.3 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Aldo_ket_red PF00248.21 CCF34033.1 - 3.5e-13 49.4 0.0 4e-13 49.2 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Dynactin_p62 PF05502.13 CCF34034.1 - 2.4e-208 692.7 2.4 5.7e-208 691.5 2.4 1.5 1 1 0 1 1 1 1 Dynactin p62 family Ribosomal_S7e PF01251.18 CCF34035.1 - 1.4e-81 272.7 0.2 1.6e-81 272.4 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e DUF4448 PF14610.6 CCF34036.1 - 1.6e-34 119.3 0.0 2.1e-34 118.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) DUF2946 PF11162.8 CCF34036.1 - 0.45 11.2 0.1 0.45 11.2 0.1 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2946) Nucleoporin_C PF03177.14 CCF34038.1 - 2.5e-191 637.5 20.6 3.3e-191 637.1 20.6 1.1 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal Nucleoporin_N PF08801.11 CCF34038.1 - 7.6e-83 278.7 0.0 9.6e-83 278.3 0.0 1.1 1 0 0 1 1 1 1 Nup133 N terminal like Neuropep_like PF15161.6 CCF34038.1 - 0.065 12.9 0.3 0.15 11.7 0.3 1.5 1 0 0 1 1 1 0 Neuropeptide-like DUF410 PF04190.13 CCF34039.1 - 6e-67 226.1 0.0 7.9e-67 225.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF410) NmrA PF05368.13 CCF34041.1 - 8.4e-18 64.8 0.0 1e-17 64.5 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CCF34041.1 - 1.9e-13 50.7 0.0 2.9e-13 50.1 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Shikimate_DH PF01488.20 CCF34041.1 - 0.00054 20.0 0.0 0.001 19.1 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase DapB_N PF01113.20 CCF34041.1 - 0.0036 17.4 0.0 0.0076 16.4 0.0 1.5 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Epimerase PF01370.21 CCF34041.1 - 0.067 12.6 0.1 0.6 9.5 0.0 2.3 3 0 0 3 3 3 0 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 CCF34041.1 - 0.098 13.1 0.0 0.23 11.9 0.0 1.6 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Porin_3 PF01459.22 CCF34042.1 - 2.4e-86 289.5 0.6 2.9e-86 289.3 0.6 1.0 1 0 0 1 1 1 1 Eukaryotic porin CWC25 PF12542.8 CCF34043.1 - 9.7e-24 84.2 0.3 9.7e-24 84.2 0.3 3.6 4 1 0 4 4 4 1 Pre-mRNA splicing factor Ras PF00071.22 CCF34044.1 - 1.9e-54 183.6 0.0 2.3e-54 183.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCF34044.1 - 1.2e-21 77.1 0.0 2.3e-21 76.2 0.0 1.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCF34044.1 - 1.1e-09 37.9 0.0 1.8e-09 37.3 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 CCF34044.1 - 0.00045 19.6 0.0 0.00058 19.3 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 CCF34044.1 - 0.0041 16.3 0.0 0.0057 15.9 0.0 1.3 1 1 0 1 1 1 1 G-protein alpha subunit SRPRB PF09439.10 CCF34044.1 - 0.0055 16.2 0.0 0.0074 15.7 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 CCF34044.1 - 0.01 15.9 0.0 0.02 15.0 0.0 1.6 1 1 0 1 1 1 0 50S ribosome-binding GTPase ABC_tran PF00005.27 CCF34044.1 - 0.11 13.1 0.0 0.28 11.7 0.0 1.4 1 1 0 1 1 1 0 ABC transporter BAH PF01426.18 CCF34046.1 - 0.0012 18.7 0.2 0.0033 17.3 0.1 1.9 1 1 1 2 2 2 1 BAH domain PHD PF00628.29 CCF34046.1 - 0.003 17.4 1.8 0.003 17.4 1.8 1.8 2 0 0 2 2 2 1 PHD-finger FANCL_C PF11793.8 CCF34046.1 - 0.012 15.7 1.2 0.028 14.6 1.2 1.5 1 0 0 1 1 1 0 FANCL C-terminal domain Lipoprotein_20 PF13942.6 CCF34046.1 - 0.042 13.8 1.8 1.6 8.6 0.2 2.3 2 0 0 2 2 2 0 YfhG lipoprotein RAG2_PHD PF13341.6 CCF34046.1 - 0.11 12.6 0.0 0.35 11.0 0.0 1.8 1 0 0 1 1 1 0 RAG2 PHD domain zf-HC5HC2H PF13771.6 CCF34046.1 - 0.11 12.8 3.1 0.079 13.2 1.2 1.7 2 0 0 2 2 2 0 PHD-like zinc-binding domain DUF1387 PF07139.11 CCF34046.1 - 2.9 7.5 10.0 1 9.0 1.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1387) ATG22 PF11700.8 CCF34047.1 - 9.6e-198 657.6 10.4 1.1e-197 657.4 10.4 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like MFS_2 PF13347.6 CCF34047.1 - 0.0011 17.6 6.2 0.0011 17.6 6.2 2.7 3 0 0 3 3 3 2 MFS/sugar transport protein Tyrosinase PF00264.20 CCF34048.1 - 1.9e-49 169.0 1.2 2.4e-49 168.6 1.2 1.1 1 0 0 1 1 1 1 Common central domain of tyrosinase CRR7 PF12095.8 CCF34049.1 - 0.075 13.5 0.1 8.2 6.9 0.0 2.2 2 0 0 2 2 2 0 Protein CHLORORESPIRATORY REDUCTION 7 Mannitol_dh PF01232.23 CCF34050.1 - 4.3e-16 59.4 0.0 4.7e-16 59.3 0.0 1.0 1 0 0 1 1 1 1 Mannitol dehydrogenase Rossmann domain UDPG_MGDP_dh_N PF03721.14 CCF34050.1 - 0.0005 19.7 0.1 0.00061 19.4 0.1 1.1 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 3HCDH_N PF02737.18 CCF34050.1 - 0.0025 17.7 0.0 0.003 17.5 0.0 1.1 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ApbA PF02558.16 CCF34050.1 - 0.067 12.8 0.0 0.087 12.5 0.0 1.2 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA DUF2250 PF10007.9 CCF34051.1 - 0.16 12.1 1.8 0.18 11.9 1.1 1.5 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2250) OB_NTP_bind PF07717.16 CCF34052.1 - 8.9e-23 80.5 0.0 1.8e-22 79.5 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 CCF34052.1 - 5e-22 78.2 0.1 5e-22 78.2 0.1 2.6 3 0 0 3 3 3 1 Helicase associated domain (HA2) Helicase_C PF00271.31 CCF34052.1 - 5.9e-13 49.1 0.0 1.4e-12 48.0 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain S1 PF00575.23 CCF34052.1 - 7e-12 45.5 1.2 1.4e-11 44.5 1.2 1.5 1 0 0 1 1 1 1 S1 RNA binding domain AAA_22 PF13401.6 CCF34052.1 - 1.4e-07 31.9 0.0 3.3e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain DEAD PF00270.29 CCF34052.1 - 1.9e-05 24.5 0.4 4.7e-05 23.2 0.4 1.6 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_30 PF13604.6 CCF34052.1 - 0.00015 21.5 0.2 0.0004 20.2 0.2 1.6 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CCF34052.1 - 0.00053 20.3 0.3 0.001 19.4 0.3 1.4 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 CCF34052.1 - 0.0021 17.2 0.0 0.0048 16.0 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein PhoH PF02562.16 CCF34052.1 - 0.059 12.8 0.0 0.15 11.5 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein DUF2075 PF09848.9 CCF34052.1 - 0.072 12.3 0.0 0.14 11.4 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) ABC_tran PF00005.27 CCF34052.1 - 0.091 13.3 0.1 1.3 9.6 0.1 2.6 1 1 0 1 1 1 0 ABC transporter AAA_14 PF13173.6 CCF34052.1 - 0.1 12.6 0.1 0.69 10.0 0.1 2.1 1 1 0 1 1 1 0 AAA domain RSRP PF17069.5 CCF34052.1 - 0.31 10.6 22.5 0.71 9.4 22.5 1.5 1 0 0 1 1 1 0 Arginine/Serine-Rich protein 1 IPK PF03770.16 CCF34053.1 - 6.1e-53 179.6 0.0 9.1e-53 179.1 0.0 1.3 1 0 0 1 1 1 1 Inositol polyphosphate kinase Nucleos_tra2_C PF07662.13 CCF34054.1 - 1.2e-72 244.1 2.6 1.2e-72 244.1 2.6 2.8 3 1 0 3 3 3 1 Na+ dependent nucleoside transporter C-terminus Nucleos_tra2_N PF01773.20 CCF34054.1 - 3.8e-22 78.7 1.1 3.8e-22 78.7 1.1 3.5 4 0 0 4 4 4 1 Na+ dependent nucleoside transporter N-terminus ATP1G1_PLM_MAT8 PF02038.16 CCF34054.1 - 0.042 13.3 2.2 0.18 11.3 2.2 2.1 1 0 0 1 1 1 0 ATP1G1/PLM/MAT8 family DUF1449 PF07290.11 CCF34054.1 - 0.8 9.3 6.4 0.37 10.4 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1449) Gate PF07670.14 CCF34054.1 - 4.2 7.7 20.2 0.43 10.9 7.7 3.6 3 0 0 3 3 3 0 Nucleoside recognition Beta_helix PF13229.6 CCF34055.1 - 3.8e-09 36.6 3.8 4.8e-09 36.2 1.8 1.8 2 0 0 2 2 2 1 Right handed beta helix region Chondroitinas_B PF14592.6 CCF34055.1 - 1e-06 27.9 0.0 1.8e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 Chondroitinase B DUF1565 PF07602.11 CCF34055.1 - 0.0016 17.8 0.1 0.0034 16.8 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1565) Fungal_trans PF04082.18 CCF34057.1 - 1.2e-11 44.2 0.0 3.5e-11 42.6 0.0 1.7 1 1 1 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF34057.1 - 0.0004 20.4 6.7 0.00072 19.6 6.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Spt20 PF12090.8 CCF34059.1 - 6e-55 186.4 0.0 6e-55 186.4 0.0 7.0 4 2 0 4 4 4 1 Spt20 family ATG27 PF09451.10 CCF34060.1 - 6.4e-101 337.6 0.0 7.8e-101 337.4 0.0 1.0 1 0 0 1 1 1 1 Autophagy-related protein 27 Asp-B-Hydro_N PF05279.11 CCF34060.1 - 2.6 8.0 6.8 0.23 11.5 1.7 1.7 2 0 0 2 2 2 0 Aspartyl beta-hydroxylase N-terminal region TPR_19 PF14559.6 CCF34061.1 - 0.073 13.6 2.0 8.1 7.0 0.0 3.8 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 CCF34061.1 - 0.2 11.9 5.4 3.8 7.9 0.0 3.5 3 1 0 3 3 3 0 Tetratricopeptide repeat EthD PF07110.11 CCF34062.1 - 6.8e-16 59.2 0.0 8e-16 59.0 0.0 1.1 1 0 0 1 1 1 1 EthD domain MmlI PF09448.10 CCF34062.1 - 1.4e-05 25.5 0.0 2.5e-05 24.7 0.0 1.4 1 1 0 1 1 1 1 Methylmuconolactone methyl-isomerase Ceramidase PF05875.12 CCF34063.1 - 3.1e-59 200.6 3.4 3.7e-59 200.3 3.4 1.0 1 0 0 1 1 1 1 Ceramidase SID-1_RNA_chan PF13965.6 CCF34063.1 - 0.03 12.8 1.4 0.045 12.2 1.4 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Glyco_tranf_2_3 PF13641.6 CCF34064.1 - 2.2e-21 76.8 0.3 2.7e-21 76.5 0.3 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 CCF34064.1 - 5.6e-08 32.5 0.4 2.8e-07 30.2 0.4 2.0 1 1 0 1 1 1 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 CCF34064.1 - 2.6e-05 24.1 0.0 5.1e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_5 PF13712.6 CCF34064.1 - 0.12 12.1 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 Glycosyltransferase like family PHB_acc PF05233.13 CCF34064.1 - 0.21 11.7 0.1 0.38 10.8 0.1 1.4 1 0 0 1 1 1 0 PHB accumulation regulatory domain CcmD PF04995.14 CCF34065.1 - 7.1e-05 22.8 2.3 0.00017 21.6 2.3 1.6 1 0 0 1 1 1 1 Heme exporter protein D (CcmD) TMEM100 PF16311.5 CCF34065.1 - 0.0091 15.6 0.4 0.021 14.4 0.4 1.5 1 0 0 1 1 1 1 Transmembrane protein 100 DUF3433 PF11915.8 CCF34066.1 - 4.6e-19 68.7 3.5 4.6e-19 68.7 3.5 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF3433) Aminotran_1_2 PF00155.21 CCF34068.1 - 4.2e-06 26.2 0.0 4.9e-06 26.0 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II DUF3435 PF11917.8 CCF34072.1 - 6.1e-64 216.5 1.5 9.4e-64 215.9 0.1 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF3435) RRP36 PF06102.12 CCF34072.1 - 3 7.8 10.8 0.27 11.2 5.5 1.9 2 0 0 2 2 2 0 rRNA biogenesis protein RRP36 TRAUB PF08164.12 CCF34073.1 - 7e-20 71.3 1.2 7.8e-20 71.2 1.2 1.2 1 0 0 1 1 1 1 Apoptosis-antagonizing transcription factor, C-terminal Chal_sti_synt_N PF00195.19 CCF34076.1 - 1.1e-22 80.6 0.2 1.8e-22 79.9 0.2 1.2 1 0 0 1 1 1 1 Chalcone and stilbene synthases, N-terminal domain Chal_sti_synt_C PF02797.15 CCF34076.1 - 1.3e-20 74.0 0.0 2.4e-20 73.0 0.0 1.4 1 0 0 1 1 1 1 Chalcone and stilbene synthases, C-terminal domain FAE1_CUT1_RppA PF08392.12 CCF34076.1 - 6.3e-05 22.4 0.3 0.00011 21.7 0.0 1.5 2 0 0 2 2 2 1 FAE1/Type III polyketide synthase-like protein ACP_syn_III_C PF08541.10 CCF34076.1 - 0.003 17.7 0.0 0.0094 16.1 0.0 1.9 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ACP_syn_III PF08545.10 CCF34076.1 - 0.043 13.7 0.7 0.14 12.0 0.3 2.1 2 1 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Glyco_hydro_16 PF00722.21 CCF34077.1 - 6.2e-08 32.3 0.0 2e-07 30.7 0.0 1.9 1 1 0 1 1 1 1 Glycosyl hydrolases family 16 SKN1 PF03935.15 CCF34077.1 - 0.0079 14.6 0.0 0.015 13.8 0.0 1.3 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) LdpA_C PF12617.8 CCF34077.1 - 0.13 11.9 0.1 0.22 11.1 0.1 1.3 1 0 0 1 1 1 0 Iron-Sulfur binding protein C terminal Pex14_N PF04695.13 CCF34077.1 - 1.2 9.8 10.9 2.5 8.7 10.9 1.5 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region bPH_2 PF03703.14 CCF34078.1 - 0.075 13.2 0.0 0.1 12.8 0.0 1.3 1 0 0 1 1 1 0 Bacterial PH domain Cation_ATPase_C PF00689.21 CCF34080.1 - 3.3e-45 154.0 6.0 3.3e-45 154.0 6.0 2.2 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 CCF34080.1 - 2.2e-35 121.8 1.1 2.2e-35 121.8 1.1 3.3 4 0 0 4 4 4 1 E1-E2 ATPase Hydrolase PF00702.26 CCF34080.1 - 3e-22 79.9 3.7 8.1e-22 78.5 3.7 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CCF34080.1 - 4.1e-22 78.1 0.0 8.4e-22 77.1 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 CCF34080.1 - 5.6e-13 48.4 0.0 2.8e-10 39.7 0.0 2.8 2 0 0 2 2 2 2 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 CCF34080.1 - 0.00027 20.8 0.3 0.00097 18.9 0.2 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Adeno_PX PF05829.12 CCF34080.1 - 0.17 11.7 0.6 0.41 10.6 0.1 1.9 2 0 0 2 2 2 0 Adenovirus late L2 mu core protein (Protein X) zf-SCNM1 PF15803.5 CCF34082.1 - 0.077 12.7 0.3 0.18 11.5 0.3 1.6 1 0 0 1 1 1 0 Zinc-finger of sodium channel modifier 1 Kelch_1 PF01344.25 CCF34083.1 - 5e-42 141.3 15.8 9.8e-10 37.9 0.3 6.3 6 0 0 6 6 6 6 Kelch motif Kelch_3 PF13415.6 CCF34083.1 - 1.2e-40 137.1 13.7 3.7e-10 39.8 0.1 7.1 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_5 PF13854.6 CCF34083.1 - 3.2e-40 135.5 14.0 6.3e-07 29.2 0.1 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_4 PF13418.6 CCF34083.1 - 4.8e-37 125.7 15.8 5.5e-08 32.7 0.1 6.4 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_6 PF13964.6 CCF34083.1 - 7e-36 121.4 11.0 4.7e-07 29.9 0.0 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_2 PF07646.15 CCF34083.1 - 1e-32 110.8 16.0 4.5e-08 32.8 0.3 6.6 6 0 0 6 6 6 6 Kelch motif HSF_DNA-bind PF00447.17 CCF34085.1 - 2.6e-26 92.1 2.2 5.6e-26 91.0 2.2 1.5 1 0 0 1 1 1 1 HSF-type DNA-binding Response_reg PF00072.24 CCF34085.1 - 3.3e-21 75.5 0.0 7.2e-21 74.4 0.0 1.6 1 0 0 1 1 1 1 Response regulator receiver domain YabA PF06156.13 CCF34085.1 - 0.086 13.5 4.9 0.18 12.5 4.9 1.5 1 0 0 1 1 1 0 Initiation control protein YabA DUF16 PF01519.16 CCF34085.1 - 0.11 13.0 5.5 0.21 12.1 5.5 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF16 bZIP_1 PF00170.21 CCF34085.1 - 0.19 11.8 1.3 0.3 11.2 0.4 1.8 2 0 0 2 2 2 0 bZIP transcription factor DivIC PF04977.15 CCF34085.1 - 0.26 11.1 3.3 0.53 10.1 3.3 1.5 1 0 0 1 1 1 0 Septum formation initiator DIOX_N PF14226.6 CCF34086.1 - 3.6e-22 79.3 0.0 5.2e-21 75.6 0.0 2.3 2 0 0 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 CCF34086.1 - 2.5e-11 43.9 0.0 4.9e-11 43.0 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily MFS_1 PF07690.16 CCF34087.1 - 3.8e-23 82.0 27.4 3.8e-23 82.0 27.4 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF5336 PF17270.2 CCF34087.1 - 0.03 14.0 0.1 0.058 13.0 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5336) AA_permease_2 PF13520.6 CCF34088.1 - 3.8e-37 128.1 54.1 4.8e-37 127.8 54.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CCF34088.1 - 8.2e-12 44.5 51.5 1.4e-11 43.7 51.5 1.3 1 1 0 1 1 1 1 Amino acid permease VIT1 PF01988.19 CCF34088.1 - 0.016 15.1 0.2 0.016 15.1 0.2 3.0 2 1 0 2 2 2 0 VIT family SNF2_N PF00176.23 CCF34089.1 - 3.5e-72 243.1 1.3 3.5e-72 243.1 1.3 1.9 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CCF34089.1 - 2e-20 73.2 0.2 1.4e-18 67.3 0.0 3.9 3 0 0 3 3 3 1 Helicase conserved C-terminal domain Bromodomain PF00439.25 CCF34089.1 - 2.5e-19 69.1 0.2 6.9e-19 67.7 0.2 1.7 1 0 0 1 1 1 1 Bromodomain HSA PF07529.13 CCF34089.1 - 1.1e-16 60.9 13.7 1.1e-16 60.9 13.7 5.5 6 0 0 6 6 6 1 HSA SnAC PF14619.6 CCF34089.1 - 3.7e-13 49.9 0.3 3.7e-13 49.9 0.3 3.5 2 1 1 3 3 3 1 Snf2-ATP coupling, chromatin remodelling complex QLQ PF08880.11 CCF34089.1 - 1.1e-11 44.3 7.8 4.4e-11 42.3 7.8 2.2 1 0 0 1 1 1 1 QLQ ResIII PF04851.15 CCF34089.1 - 1.7e-10 41.1 0.1 1.7e-10 41.1 0.1 3.6 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit RBR PF17208.3 CCF34089.1 - 0.00013 22.6 4.6 0.00013 22.6 4.6 2.5 1 1 1 2 2 2 1 RNA binding Region LMBR1 PF04791.16 CCF34089.1 - 6.3 5.6 9.9 16 4.3 9.9 1.6 1 0 0 1 1 1 0 LMBR1-like membrane protein Zn_clus PF00172.18 CCF34090.1 - 8.2e-11 41.9 7.6 1.3e-10 41.2 7.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Spem1 PF15670.5 CCF34090.1 - 0.21 11.1 4.6 1.3 8.5 4.5 1.8 1 1 0 1 1 1 0 Spermatid maturation protein 1 Aldedh PF00171.22 CCF34093.1 - 1.5e-73 247.9 0.1 1.7e-73 247.7 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Whi5 PF08528.11 CCF34094.1 - 2e-09 36.9 0.1 3.6e-09 36.0 0.1 1.5 1 0 0 1 1 1 1 Whi5 like TFIIA PF03153.13 CCF34094.1 - 0.049 13.6 16.9 0.063 13.3 16.9 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Presenilin PF01080.17 CCF34094.1 - 1.1 8.0 9.3 1.8 7.3 9.3 1.3 1 0 0 1 1 1 0 Presenilin SEEEED PF14797.6 CCF34094.1 - 2 8.6 12.1 4.1 7.6 12.1 1.5 1 0 0 1 1 1 0 Serine-rich region of AP3B1, clathrin-adaptor complex RTA1 PF04479.13 CCF34095.1 - 5.4e-60 202.5 10.5 8.2e-60 201.9 10.5 1.2 1 0 0 1 1 1 1 RTA1 like protein DUF3007 PF11460.8 CCF34095.1 - 0.49 10.7 0.1 0.49 10.7 0.1 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF3007) MFS_1 PF07690.16 CCF34096.1 - 2.6e-30 105.5 22.0 3.2e-23 82.2 7.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DIOX_N PF14226.6 CCF34097.1 - 1.4e-13 51.6 0.0 3e-13 50.6 0.0 1.5 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 CCF34097.1 - 7.9e-10 39.1 0.0 1.5e-09 38.2 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Aminotran_MocR PF12897.7 CCF34097.1 - 0.1 11.3 0.0 0.99 8.1 0.0 2.0 1 1 1 2 2 2 0 Alanine-glyoxylate amino-transferase NAD_binding_2 PF03446.15 CCF34098.1 - 1.6e-24 86.9 0.3 2.8e-24 86.1 0.3 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 CCF34098.1 - 3.2e-09 37.1 0.0 7.8e-09 35.8 0.0 1.7 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.17 CCF34098.1 - 2.7e-05 24.6 0.3 0.00012 22.6 0.0 2.2 3 0 0 3 3 3 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 CCF34098.1 - 0.00014 21.9 0.0 0.00024 21.2 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 CCF34098.1 - 0.044 13.2 0.0 0.077 12.3 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GST_C PF00043.25 CCF34099.1 - 1.2e-11 44.6 0.0 1.9e-11 44.0 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CCF34099.1 - 6.8e-10 38.8 0.4 2.3e-09 37.1 0.1 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 CCF34099.1 - 1.7e-07 31.3 0.0 3.4e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 CCF34099.1 - 1.4e-06 28.5 0.0 2.8e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 CCF34099.1 - 7.7e-05 23.0 0.0 0.00016 22.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain 2OG-FeII_Oxy PF03171.20 CCF34100.1 - 5.6e-08 33.2 0.0 9.9e-08 32.4 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily TRH PF05438.12 CCF34100.1 - 0.091 12.5 0.0 0.14 11.9 0.0 1.2 1 0 0 1 1 1 0 Thyrotropin-releasing hormone (TRH) DUF3455 PF11937.8 CCF34101.1 - 6.1e-30 104.7 0.1 7.5e-30 104.4 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3455) Peptidase_M43 PF05572.13 CCF34102.1 - 2.7e-09 37.1 0.1 4.1e-09 36.5 0.1 1.3 1 0 0 1 1 1 1 Pregnancy-associated plasma protein-A Reprolysin_4 PF13583.6 CCF34102.1 - 0.00063 19.4 0.1 0.0008 19.1 0.1 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 CCF34102.1 - 0.001 19.3 1.2 0.0014 18.8 1.2 1.5 1 1 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_2 PF13574.6 CCF34102.1 - 0.0049 16.8 0.2 0.0076 16.2 0.2 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.24 CCF34102.1 - 0.0063 16.4 0.1 0.0067 16.3 0.1 1.3 1 1 0 1 1 1 1 Matrixin Metallopep PF12044.8 CCF34102.1 - 0.011 14.4 0.1 0.015 14.0 0.1 1.1 1 0 0 1 1 1 0 Putative peptidase family Reprolysin_3 PF13582.6 CCF34102.1 - 0.02 15.4 0.4 0.034 14.7 0.4 1.6 1 1 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like DUF4953 PF16313.5 CCF34102.1 - 0.072 12.3 0.1 0.1 11.8 0.1 1.2 1 0 0 1 1 1 0 Met-zincin Peptidase_M66 PF10462.9 CCF34102.1 - 0.16 10.9 0.2 0.22 10.4 0.2 1.2 1 0 0 1 1 1 0 Peptidase M66 Oxidored_FMN PF00724.20 CCF34104.1 - 2.9e-80 270.1 0.0 3.8e-80 269.7 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family adh_short PF00106.25 CCF34105.1 - 6.5e-30 104.0 0.0 8.9e-30 103.6 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF34105.1 - 2.4e-19 69.8 0.1 3.2e-19 69.4 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF34105.1 - 1.7e-07 31.3 0.4 7.4e-07 29.3 0.4 1.9 1 1 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 CCF34105.1 - 0.0013 18.7 0.9 0.0038 17.1 0.9 1.9 1 1 0 1 1 1 1 NAD(P)H-binding 3HCDH_N PF02737.18 CCF34105.1 - 0.0042 17.0 0.1 0.0072 16.2 0.1 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Epimerase PF01370.21 CCF34105.1 - 0.0058 16.1 0.1 0.032 13.7 0.1 1.9 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family YjeF_N PF03853.15 CCF34105.1 - 0.073 13.0 0.1 0.26 11.1 0.0 1.9 2 0 0 2 2 2 0 YjeF-related protein N-terminus EamA PF00892.20 CCF34106.1 - 2.8e-11 43.7 21.7 1e-05 25.7 0.3 2.9 3 0 0 3 3 3 2 EamA-like transporter family CSG2 PF16965.5 CCF34106.1 - 5.6e-07 28.9 10.8 2.5e-06 26.7 10.7 2.2 1 1 0 1 1 1 1 Ceramide synthase regulator Nuc_sug_transp PF04142.15 CCF34106.1 - 0.033 13.4 6.5 0.051 12.7 0.0 2.0 2 0 0 2 2 2 0 Nucleotide-sugar transporter DUF202 PF02656.15 CCF34106.1 - 0.079 13.4 9.7 0.2 12.1 1.8 4.0 4 1 0 4 4 4 0 Domain of unknown function (DUF202) Aldo_ket_red PF00248.21 CCF34107.1 - 3.3e-54 184.1 0.0 3.8e-54 183.9 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Glyco_hydro_16 PF00722.21 CCF34109.1 - 9e-14 51.3 0.0 3.6e-13 49.4 0.0 1.8 1 1 0 1 1 1 1 Glycosyl hydrolases family 16 SKN1 PF03935.15 CCF34109.1 - 2.6e-06 26.1 0.6 0.0034 15.9 0.0 2.1 2 0 0 2 2 2 2 Beta-glucan synthesis-associated protein (SKN1) zf-C2H2_2 PF12756.7 CCF34110.1 - 1.3e-35 121.8 12.8 5.8e-30 103.6 4.1 3.5 3 0 0 3 3 3 3 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 CCF34110.1 - 6.8e-09 35.8 14.0 9.4e-08 32.2 3.5 4.2 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CCF34110.1 - 7.1e-07 29.4 2.8 7.1e-07 29.4 2.8 2.5 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 CCF34110.1 - 0.00031 21.3 16.3 0.18 12.8 0.2 5.2 5 0 0 5 5 5 2 C2H2-type zinc finger SnoaL_2 PF12680.7 CCF34110.1 - 0.023 15.4 3.1 0.25 12.0 2.5 2.6 2 0 0 2 2 2 0 SnoaL-like domain zf-3CxxC_2 PF17180.4 CCF34110.1 - 0.42 11.4 3.3 1.8 9.3 0.1 3.0 3 0 0 3 3 3 0 Zinc-binding domain zf-C2H2 PF00096.26 CCF34110.1 - 0.43 11.1 20.2 3.3 8.3 0.6 4.6 4 0 0 4 4 4 0 Zinc finger, C2H2 type MMR_HSR1 PF01926.23 CCF34111.1 - 1.2e-17 64.0 0.0 1.9e-17 63.4 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 CCF34111.1 - 2.1e-07 31.2 0.6 0.0028 17.7 0.8 2.2 2 0 0 2 2 2 2 Dynamin family IIGP PF05049.13 CCF34111.1 - 9.8e-07 28.1 0.0 0.016 14.3 0.1 2.1 2 0 0 2 2 2 2 Interferon-inducible GTPase (IIGP) FeoB_N PF02421.18 CCF34111.1 - 6.1e-06 25.8 0.1 0.00025 20.6 0.2 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 CCF34111.1 - 0.00019 21.0 0.0 0.0014 18.2 0.0 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 CCF34111.1 - 0.0094 15.9 0.4 0.14 12.1 0.1 2.7 3 0 0 3 3 3 1 RsgA GTPase Septin PF00735.18 CCF34111.1 - 0.044 13.1 0.0 0.13 11.5 0.0 1.7 1 1 0 1 1 1 0 Septin AAA_15 PF13175.6 CCF34111.1 - 0.1 12.3 0.0 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain AIG1 PF04548.16 CCF34111.1 - 0.1 11.9 0.1 9.1 5.5 0.0 2.1 2 0 0 2 2 2 0 AIG1 family PRK PF00485.18 CCF34111.1 - 0.28 10.9 0.7 0.51 10.0 0.7 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family zf-C3HC PF07967.13 CCF34112.1 - 9.3e-40 135.7 3.1 2.4e-35 121.5 0.4 3.0 3 0 0 3 3 3 2 C3HC zinc finger-like Rsm1 PF08600.10 CCF34112.1 - 2.2e-27 95.1 2.0 7.7e-27 93.3 0.1 2.4 2 1 0 2 2 2 1 Rsm1-like BIR PF00653.21 CCF34112.1 - 0.00018 22.1 0.2 0.004 17.8 0.1 2.5 2 0 0 2 2 2 1 Inhibitor of Apoptosis domain Dicty_REP PF05086.12 CCF34112.1 - 1.1 7.1 4.6 1.4 6.8 4.6 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein AMP-binding PF00501.28 CCF34116.1 - 3.8e-71 239.9 0.0 7.1e-71 239.0 0.0 1.4 1 0 0 1 1 1 1 AMP-binding enzyme Condensation PF00668.20 CCF34116.1 - 1.1e-68 232.0 0.0 1.7e-68 231.4 0.0 1.1 1 0 0 1 1 1 1 Condensation domain NAD_binding_4 PF07993.12 CCF34116.1 - 5e-20 71.7 0.0 3.2e-19 69.1 0.0 2.2 1 1 0 1 1 1 1 Male sterility protein PP-binding PF00550.25 CCF34116.1 - 3.5e-15 56.1 0.0 2.7e-08 34.1 0.0 2.8 2 0 0 2 2 2 2 Phosphopantetheine attachment site AMP-binding_C PF13193.6 CCF34116.1 - 2.4e-05 25.2 0.1 0.00013 22.9 0.0 2.3 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain RmlD_sub_bind PF04321.17 CCF34116.1 - 0.0019 17.4 1.1 0.016 14.3 0.0 2.6 3 0 0 3 3 3 1 RmlD substrate binding domain DAO PF01266.24 CCF34117.1 - 1.7e-31 110.1 0.1 2.3e-31 109.7 0.1 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 CCF34117.1 - 2.4e-05 24.3 0.1 0.015 15.3 0.0 2.4 2 0 0 2 2 2 2 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 CCF34117.1 - 0.00044 20.4 0.2 0.0015 18.7 0.0 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CCF34117.1 - 0.002 17.4 0.1 0.043 13.0 0.1 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 CCF34117.1 - 0.0082 15.0 0.0 1.1 8.0 0.0 2.3 2 0 0 2 2 2 2 Tryptophan halogenase Pyr_redox_3 PF13738.6 CCF34117.1 - 0.0097 15.2 0.0 1.3 8.2 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CCF34117.1 - 0.045 12.8 0.0 0.15 11.1 0.0 1.8 2 0 0 2 2 2 0 Glucose inhibited division protein A NAD_binding_7 PF13241.6 CCF34117.1 - 0.067 13.6 0.0 0.13 12.7 0.0 1.5 1 1 0 1 1 1 0 Putative NAD(P)-binding Thi4 PF01946.17 CCF34117.1 - 0.16 11.2 0.0 0.3 10.3 0.0 1.3 1 0 0 1 1 1 0 Thi4 family Zn_clus PF00172.18 CCF34118.1 - 4.8e-09 36.2 9.4 1.1e-08 35.0 9.4 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CCF34118.1 - 1.3e-06 27.7 0.6 2.8e-06 26.6 0.6 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain GP3_package PF16677.5 CCF34118.1 - 0.025 14.7 0.1 0.39 10.9 0.0 2.5 2 0 0 2 2 2 0 DNA-packaging protein gp3 SCIMP PF15050.6 CCF34118.1 - 0.083 13.4 0.0 0.27 11.7 0.0 1.8 1 0 0 1 1 1 0 SCIMP protein gerPA PF10676.9 CCF34118.1 - 3.1 8.1 5.1 1.6 9.1 0.8 2.3 2 0 0 2 2 2 0 Spore germination protein gerPA/gerPF COG5 PF10392.9 CCF34119.1 - 0.0094 16.1 0.4 0.011 15.9 0.4 1.0 1 0 0 1 1 1 1 Golgi transport complex subunit 5 Zn_clus PF00172.18 CCF34120.1 - 5.6e-08 32.8 12.3 1.1e-07 31.9 12.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glucosamine_iso PF01182.20 CCF34121.1 - 1.9e-27 96.6 0.0 2e-27 96.5 0.0 1.0 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase DUF2142 PF09913.9 CCF34121.1 - 0.19 10.6 0.0 0.19 10.5 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2142) SET PF00856.28 CCF34122.1 - 8.4e-05 23.0 0.0 0.00028 21.3 0.0 1.9 1 1 0 1 1 1 1 SET domain zf-MYND PF01753.18 CCF34122.1 - 0.011 15.8 5.9 0.011 15.8 5.9 2.2 2 0 0 2 2 2 0 MYND finger DUF1771 PF08590.10 CCF34123.1 - 9.9e-25 86.7 10.7 1.9e-24 85.8 10.7 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1771) Smr PF01713.21 CCF34123.1 - 2.1e-09 37.6 0.2 6.8e-09 36.0 0.2 1.9 1 0 0 1 1 1 1 Smr domain DUF4407 PF14362.6 CCF34123.1 - 0.036 13.4 3.1 0.046 13.1 3.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) OmpH PF03938.14 CCF34123.1 - 0.52 10.6 7.6 0.31 11.4 2.6 2.2 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) zf-Tim10_DDP PF02953.15 CCF34124.1 - 2.9e-18 65.2 5.7 5.1e-18 64.5 5.7 1.4 1 0 0 1 1 1 1 Tim10/DDP family zinc finger UPF0137 PF03677.13 CCF34124.1 - 0.046 13.5 2.0 0.051 13.4 2.0 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0137) c-SKI_SMAD_bind PF08782.10 CCF34124.1 - 0.047 13.9 0.7 0.083 13.1 0.7 1.4 1 0 0 1 1 1 0 c-SKI Smad4 binding domain ABC_tran PF00005.27 CCF34126.1 - 1.2e-39 136.0 0.0 9e-22 78.1 0.0 2.7 3 0 0 3 3 2 2 ABC transporter ABC_membrane PF00664.23 CCF34126.1 - 8.5e-26 91.2 25.7 5.1e-21 75.5 10.2 2.6 3 0 0 3 3 2 2 ABC transporter transmembrane region SMC_N PF02463.19 CCF34126.1 - 3.4e-10 39.7 0.0 0.025 14.0 0.0 4.9 4 1 1 5 5 5 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CCF34126.1 - 2e-05 24.3 0.1 0.13 12.0 0.0 2.9 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 CCF34126.1 - 8.4e-05 22.9 0.0 0.56 10.5 0.0 2.9 3 0 0 3 3 2 2 AAA domain AAA_21 PF13304.6 CCF34126.1 - 0.00031 20.6 0.1 1 9.1 0.0 3.8 3 1 1 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system MMR_HSR1 PF01926.23 CCF34126.1 - 0.0021 18.1 0.1 2.6 8.2 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_33 PF13671.6 CCF34126.1 - 0.0031 17.7 0.0 0.24 11.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain Dynamin_N PF00350.23 CCF34126.1 - 0.0036 17.4 0.0 0.3 11.1 0.0 2.3 2 0 0 2 2 2 1 Dynamin family RsgA_GTPase PF03193.16 CCF34126.1 - 0.0041 17.0 0.1 0.53 10.2 0.0 2.7 3 0 0 3 3 3 1 RsgA GTPase ATP_bind_1 PF03029.17 CCF34126.1 - 0.0047 16.8 0.0 0.067 13.0 0.0 2.3 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein AAA_7 PF12775.7 CCF34126.1 - 0.0061 16.1 0.1 0.75 9.3 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_15 PF13175.6 CCF34126.1 - 0.0066 16.2 0.0 3 7.4 0.0 2.2 2 0 0 2 2 2 2 AAA ATPase domain AAA_23 PF13476.6 CCF34126.1 - 0.015 15.9 0.1 7.4 7.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 CCF34126.1 - 0.021 15.2 0.1 8.7 6.7 0.0 2.8 2 0 0 2 2 2 0 AAA ATPase domain AAA_18 PF13238.6 CCF34126.1 - 0.024 15.2 0.1 3.8 8.1 0.1 2.5 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.17 CCF34126.1 - 0.097 12.7 0.1 0.24 11.4 0.0 1.6 2 0 0 2 2 1 0 Helicase HerA, central domain CLP1_P PF16575.5 CCF34126.1 - 0.27 11.0 0.6 1.4 8.7 0.0 2.2 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop PduV-EutP PF10662.9 CCF34126.1 - 0.28 10.9 0.8 3.6 7.3 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_25 PF13481.6 CCF34126.1 - 0.58 9.7 1.9 17 4.9 0.1 3.1 2 1 0 2 2 2 0 AAA domain DUF3328 PF11807.8 CCF34127.1 - 3.9e-49 167.4 0.0 4.7e-49 167.1 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) DUF3328 PF11807.8 CCF34128.1 - 1.7e-48 165.3 0.0 2.1e-48 165.0 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Myco_arth_vir_N PF09610.10 CCF34129.1 - 0.33 11.1 2.1 0.48 10.5 2.1 1.3 1 0 0 1 1 1 0 Mycoplasma virulence signal region (Myco_arth_vir_N) MFS_1 PF07690.16 CCF34130.1 - 2.7e-12 46.3 36.7 2.7e-12 46.3 36.7 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF973 PF06157.11 CCF34130.1 - 0.11 11.5 4.0 0.19 10.7 4.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF973) GET2 PF08690.10 CCF34130.1 - 0.17 11.5 0.1 0.25 11.0 0.1 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 PTR2 PF00854.21 CCF34131.1 - 1.4e-31 109.7 4.3 1.7e-31 109.5 4.3 1.2 1 0 0 1 1 1 1 POT family Maff2 PF12750.7 CCF34131.1 - 3.2 7.6 5.5 1.1 9.2 0.0 2.9 3 1 0 3 3 3 0 Maff2 family SnoaL PF07366.12 CCF34132.1 - 3.9e-07 29.9 0.0 9e-07 28.7 0.0 1.6 2 0 0 2 2 2 1 SnoaL-like polyketide cyclase SnoaL_2 PF12680.7 CCF34132.1 - 2.1e-05 25.1 0.0 0.0001 22.9 0.0 2.0 2 0 0 2 2 2 1 SnoaL-like domain RNA_pol_Rpc4 PF05132.14 CCF34132.1 - 1.4 9.3 10.2 3.2 8.2 10.2 1.6 1 0 0 1 1 1 0 RNA polymerase III RPC4 Presenilin PF01080.17 CCF34132.1 - 1.6 7.4 9.8 2 7.1 9.8 1.1 1 0 0 1 1 1 0 Presenilin DUF1508 PF07411.12 CCF34133.1 - 0.13 12.1 0.0 0.25 11.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1508) Glyco_hydro_16 PF00722.21 CCF34135.1 - 2.9e-15 56.2 0.6 4.7e-15 55.5 0.6 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 TaqI_C PF12950.7 CCF34135.1 - 0.099 12.7 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 TaqI-like C-terminal specificity domain ATPase_gene1 PF09527.10 CCF34135.1 - 0.15 12.2 1.4 5.4 7.3 0.1 2.5 2 0 0 2 2 2 0 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter zf-C3HC4_3 PF13920.6 CCF34136.1 - 1.6e-08 34.3 4.0 1.6e-08 34.3 4.0 3.4 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CCF34136.1 - 5.2e-07 29.4 8.8 5.2e-07 29.4 8.8 3.5 2 1 2 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CCF34136.1 - 6.9e-07 29.5 8.2 6.9e-07 29.5 8.2 3.7 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4 PF00097.25 CCF34136.1 - 2.2e-06 27.4 8.7 2.2e-06 27.4 8.7 3.3 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CCF34136.1 - 3.2e-06 27.1 12.1 1.3e-05 25.1 12.1 2.1 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 CCF34136.1 - 1.1e-05 25.3 6.8 1.1e-05 25.3 6.8 3.4 2 2 1 3 3 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 CCF34136.1 - 5e-05 23.1 8.2 5e-05 23.1 8.2 3.1 3 2 1 4 4 4 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 CCF34136.1 - 0.0013 19.0 6.6 0.0013 19.0 6.6 3.8 2 2 1 3 3 3 1 RING-H2 zinc finger domain Sina PF03145.16 CCF34136.1 - 0.0018 18.3 2.5 0.0018 18.3 2.5 2.6 2 1 1 3 3 3 1 Seven in absentia protein family zf-C3HC4_4 PF15227.6 CCF34136.1 - 0.0019 18.3 8.3 0.0019 18.3 8.3 2.5 3 0 0 3 3 2 1 zinc finger of C3HC4-type, RING zf-TRAF PF02176.18 CCF34136.1 - 0.023 15.4 25.1 0.027 15.2 4.9 3.2 3 1 0 3 3 2 0 TRAF-type zinc finger U-box PF04564.15 CCF34136.1 - 0.024 14.8 0.4 0.076 13.2 0.3 2.0 2 0 0 2 2 2 0 U-box domain zf-P11 PF03854.14 CCF34136.1 - 0.035 13.8 1.9 0.035 13.8 1.9 3.2 2 2 1 3 3 3 0 P-11 zinc finger zf-RING_6 PF14835.6 CCF34136.1 - 0.17 11.8 4.9 0.079 12.8 1.6 2.2 2 1 0 2 2 2 0 zf-RING of BARD1-type protein Peptidase_C2 PF00648.21 CCF34137.1 - 6.2e-64 215.9 3.8 7e-63 212.4 3.8 2.1 1 1 0 1 1 1 1 Calpain family cysteine protease DUF2785 PF10978.8 CCF34137.1 - 0.075 12.8 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2785) A_deaminase PF00962.22 CCF34138.1 - 1.2e-24 87.2 0.0 1.4e-24 87.1 0.0 1.0 1 0 0 1 1 1 1 Adenosine/AMP deaminase Glyco_transf_24 PF18404.1 CCF34139.1 - 9.5e-149 494.1 3.7 1.3e-148 493.6 3.7 1.2 1 0 0 1 1 1 1 Glucosyltransferase 24 UDP-g_GGTase PF06427.11 CCF34139.1 - 5.3e-44 148.8 0.0 1e-43 147.9 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose:Glycoprotein Glucosyltransferase Thioredoxin_15 PF18403.1 CCF34139.1 - 6.4e-38 130.8 0.0 1.4e-37 129.7 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like domain Glyco_transf_8 PF01501.20 CCF34139.1 - 1.1e-06 28.4 0.3 2e-06 27.6 0.3 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 8 SNF2_N PF00176.23 CCF34140.1 - 7.3e-58 195.9 0.0 1.3e-57 195.1 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Rad54_N PF08658.10 CCF34140.1 - 7.6e-57 192.4 1.5 4.5e-56 189.9 2.2 1.9 2 0 0 2 2 2 1 Rad54 N terminal Helicase_C PF00271.31 CCF34140.1 - 8.6e-16 58.3 0.0 2.2e-15 56.9 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCF34140.1 - 1.8e-08 34.6 0.0 3.6e-08 33.6 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 CCF34140.1 - 0.00082 18.6 0.0 0.0036 16.5 0.0 1.9 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 Zn_Tnp_IS1 PF03811.13 CCF34140.1 - 0.059 13.1 0.7 0.2 11.4 0.7 1.9 1 0 0 1 1 1 0 InsA N-terminal domain SWI2_SNF2 PF18766.1 CCF34140.1 - 0.15 11.7 0.1 0.44 10.2 0.0 1.9 2 1 0 2 2 2 0 SWI2/SNF2 ATPase HET PF06985.11 CCF34141.1 - 2.4e-28 99.3 0.0 3.5e-28 98.8 0.0 1.3 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Pribosyl_synth PF14572.6 CCF34142.1 - 3.2e-25 89.2 0.0 3.5e-25 89.1 0.0 1.0 1 0 0 1 1 1 1 Phosphoribosyl synthetase-associated domain Ribosomal_S6e PF01092.19 CCF34143.1 - 3.2e-59 198.4 0.0 6.4e-59 197.4 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S6e Atg14 PF10186.9 CCF34143.1 - 1.7 7.7 8.2 2.2 7.3 8.2 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Ctf8 PF09696.10 CCF34144.1 - 6.2e-43 146.5 0.0 9.6e-43 145.9 0.0 1.3 1 0 0 1 1 1 1 Ctf8 DUF3287 PF11690.8 CCF34144.1 - 0.16 11.7 0.0 0.19 11.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3287) Glyco_hydro_10 PF00331.20 CCF34145.1 - 2.2e-88 296.4 0.0 2.5e-88 296.3 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 Pkr1 PF08636.10 CCF34147.1 - 6.4e-28 96.7 9.8 8.4e-28 96.3 9.8 1.1 1 0 0 1 1 1 1 ER protein Pkr1 SelK_SelG PF10961.8 CCF34147.1 - 0.04 14.5 3.8 0.079 13.6 3.4 1.7 1 1 0 1 1 1 0 Selenoprotein SelK_SelG OAD_gamma PF04277.13 CCF34147.1 - 0.077 13.6 2.7 10 6.8 2.4 2.4 1 1 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain DUF4813 PF16072.5 CCF34147.1 - 0.16 11.6 11.4 0.23 11.1 11.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4813) Chorion_3 PF05387.11 CCF34147.1 - 0.92 9.1 10.7 1.3 8.6 10.7 1.3 1 0 0 1 1 1 0 Chorion family 3 MFS_2 PF13347.6 CCF34148.1 - 2.2e-11 43.0 12.7 2.2e-11 43.0 12.7 2.9 3 1 1 4 4 4 1 MFS/sugar transport protein MFS_1_like PF12832.7 CCF34148.1 - 0.00035 19.6 4.1 0.00035 19.6 4.1 2.2 2 1 0 2 2 2 1 MFS_1 like family PUCC PF03209.15 CCF34148.1 - 0.0011 18.1 5.1 0.0011 18.1 5.1 1.6 2 0 0 2 2 2 1 PUCC protein zf-RING_UBOX PF13445.6 CCF34149.1 - 0.0042 17.1 7.0 0.0042 17.1 7.0 2.6 2 0 0 2 2 2 1 RING-type zinc-finger Sugar_tr PF00083.24 CCF34150.1 - 1.7e-26 93.1 8.3 2e-26 92.9 8.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter zf-nanos PF05741.13 CCF34151.1 - 0.071 13.3 2.4 0.18 12.1 2.3 1.7 1 1 1 2 2 2 0 Nanos RNA binding domain MFS_1 PF07690.16 CCF34152.1 - 1.6e-26 93.1 38.2 1.1e-23 83.8 19.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily 14-3-3 PF00244.20 CCF34153.1 - 5.2e-08 32.7 0.0 2.9e-07 30.2 0.0 1.9 2 0 0 2 2 2 1 14-3-3 protein DUF2516 PF10724.9 CCF34155.1 - 0.23 11.7 6.8 2.4 8.5 5.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2516) EI24 PF07264.11 CCF34155.1 - 0.65 10.2 9.7 0.13 12.5 5.8 1.6 2 0 0 2 2 2 0 Etoposide-induced protein 2.4 (EI24) EMP70 PF02990.16 CCF34155.1 - 1.2 7.8 8.9 0.073 11.7 3.7 1.5 2 0 0 2 2 2 0 Endomembrane protein 70 DUF2207 PF09972.9 CCF34155.1 - 1.5 7.5 5.8 2.5 6.7 0.6 2.0 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) AAA_16 PF13191.6 CCF34156.1 - 2.2e-08 34.7 0.0 5.5e-08 33.4 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.22 CCF34156.1 - 1.1e-07 31.3 0.0 1.9e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain ATPase_2 PF01637.18 CCF34156.1 - 2e-06 27.9 0.0 3e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_22 PF13401.6 CCF34156.1 - 0.00028 21.2 0.1 0.003 17.8 0.1 2.4 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 CCF34156.1 - 0.0051 16.6 0.1 0.014 15.1 0.0 1.8 2 1 0 2 2 2 1 AAA domain AAA_14 PF13173.6 CCF34156.1 - 0.012 15.7 0.0 0.034 14.2 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 CCF34156.1 - 0.013 16.0 0.0 0.043 14.2 0.0 2.0 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TniB PF05621.11 CCF34156.1 - 0.067 12.6 0.0 0.24 10.8 0.0 1.9 3 0 0 3 3 3 0 Bacterial TniB protein RuvB_N PF05496.12 CCF34156.1 - 0.12 12.2 0.0 0.55 10.0 0.0 1.9 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain MFS_1 PF07690.16 CCF34157.1 - 4.1e-31 108.2 51.8 1.4e-18 66.9 28.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF34157.1 - 5.8e-10 38.6 35.3 2.7e-09 36.4 14.3 2.2 2 0 0 2 2 2 2 Sugar (and other) transporter EMC3_TMCO1 PF01956.16 CCF34157.1 - 0.025 14.3 0.6 0.08 12.7 0.6 1.8 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like MFS_1_like PF12832.7 CCF34157.1 - 0.096 11.5 25.6 0.098 11.5 7.9 2.3 2 0 0 2 2 2 0 MFS_1 like family Protocadherin PF08374.11 CCF34157.1 - 0.26 11.3 0.8 1.5 8.7 0.5 2.1 2 0 0 2 2 2 0 Protocadherin Fungal_trans PF04082.18 CCF34158.1 - 5.7e-15 55.1 0.3 8.8e-15 54.4 0.3 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF34158.1 - 1.3e-05 25.2 13.8 2.3e-05 24.4 13.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain JAMP PF05571.12 CCF34159.1 - 0.79 9.3 3.7 0.41 10.2 1.0 1.7 2 0 0 2 2 2 0 JNK1/MAPK8-associated membrane protein GMC_oxred_N PF00732.19 CCF34160.1 - 2.9e-11 43.3 0.0 3e-11 43.2 0.0 1.0 1 0 0 1 1 1 1 GMC oxidoreductase NAD_binding_8 PF13450.6 CCF34160.1 - 3.1e-06 27.3 0.2 4.2e-06 26.9 0.2 1.2 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CCF34160.1 - 9.3e-06 25.5 0.0 9.3e-06 25.5 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 CCF34160.1 - 1e-05 24.8 0.1 1.2e-05 24.6 0.1 1.0 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_binding_2 PF00890.24 CCF34160.1 - 2.6e-05 23.5 0.0 2.6e-05 23.5 0.0 1.0 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 CCF34160.1 - 3.7e-05 23.1 0.1 4.1e-05 22.9 0.1 1.1 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.14 CCF34160.1 - 0.00061 19.1 0.0 0.00061 19.1 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CCF34160.1 - 0.0022 16.7 0.0 0.0024 16.6 0.0 1.0 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_3 PF13738.6 CCF34160.1 - 0.0026 17.1 0.1 0.0029 16.9 0.1 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 CCF34160.1 - 0.0037 17.5 0.0 0.0043 17.3 0.0 1.1 1 0 0 1 1 1 1 TrkA-N domain NAD_binding_9 PF13454.6 CCF34160.1 - 0.029 14.4 0.1 0.033 14.2 0.1 1.1 1 0 0 1 1 1 0 FAD-NAD(P)-binding K_oxygenase PF13434.6 CCF34160.1 - 0.041 13.0 0.0 0.048 12.8 0.0 1.0 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Trp_halogenase PF04820.14 CCF34160.1 - 0.076 11.8 0.1 0.084 11.7 0.1 1.0 1 0 0 1 1 1 0 Tryptophan halogenase FAD_binding_3 PF01494.19 CCF34160.1 - 0.077 12.2 0.0 0.084 12.1 0.0 1.0 1 0 0 1 1 1 0 FAD binding domain Romo1 PF10247.9 CCF34161.1 - 4.7e-28 97.3 15.2 8.8e-28 96.5 15.2 1.5 1 0 0 1 1 1 1 Reactive mitochondrial oxygen species modulator 1 Tim17 PF02466.19 CCF34161.1 - 0.0084 16.5 3.7 0.01 16.2 3.7 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family LapA_dom PF06305.11 CCF34161.1 - 0.35 10.7 1.9 5.8 6.8 0.0 2.2 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Gly-zipper_YMGG PF13441.6 CCF34161.1 - 2.1 8.1 6.7 0.54 10.1 3.3 1.7 2 0 0 2 2 2 0 YMGG-like Gly-zipper FHA PF00498.26 CCF34162.1 - 1.3e-17 63.9 0.1 3.6e-17 62.5 0.1 1.8 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 CCF34162.1 - 0.0013 19.0 0.0 0.0029 17.9 0.0 1.5 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain GAS PF13851.6 CCF34162.1 - 0.034 13.5 10.1 0.017 14.4 2.0 2.3 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding DUF812 PF05667.11 CCF34162.1 - 0.095 11.6 11.9 0.16 10.8 11.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF812) Vps51 PF08700.11 CCF34162.1 - 0.13 12.3 6.1 1.7 8.8 0.4 2.9 2 0 0 2 2 2 0 Vps51/Vps67 YhfZ_C PF14503.6 CCF34162.1 - 0.19 11.3 0.0 0.19 11.3 0.0 1.9 2 0 0 2 2 2 0 YhfZ C-terminal domain THOC7 PF05615.13 CCF34162.1 - 0.61 10.4 7.4 8.3 6.7 4.5 2.3 2 0 0 2 2 2 0 Tho complex subunit 7 DUF3450 PF11932.8 CCF34162.1 - 0.62 9.3 11.6 0.037 13.3 3.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3450) Prp19 PF08606.11 CCF34162.1 - 0.63 10.1 4.1 1.7 8.7 4.1 1.7 1 0 0 1 1 1 0 Prp19/Pso4-like EzrA PF06160.12 CCF34162.1 - 2 6.5 11.5 3.8 5.6 11.5 1.3 1 1 0 1 1 1 0 Septation ring formation regulator, EzrA Csm1_N PF18504.1 CCF34162.1 - 3.3 8.1 7.6 1.2 9.5 0.7 2.7 2 0 0 2 2 2 0 Csm1 N-terminal domain Fib_alpha PF08702.10 CCF34162.1 - 5.1 7.3 6.2 3.3e+02 1.4 6.5 2.7 2 1 0 2 2 1 0 Fibrinogen alpha/beta chain family Jnk-SapK_ap_N PF09744.9 CCF34162.1 - 5.6 7.2 13.9 6.5 7.0 3.1 2.4 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 FUSC PF04632.12 CCF34162.1 - 5.7 5.3 7.0 0.79 8.2 2.3 1.7 2 0 0 2 2 2 0 Fusaric acid resistance protein family ZapB PF06005.12 CCF34162.1 - 6.1 7.4 8.7 0.47 10.9 1.0 2.6 2 0 0 2 2 2 0 Cell division protein ZapB Ax_dynein_light PF10211.9 CCF34162.1 - 6.6 6.6 10.9 0.78 9.7 2.9 2.4 2 0 0 2 2 2 0 Axonemal dynein light chain Uds1 PF15456.6 CCF34162.1 - 6.8 6.9 12.4 0.24 11.6 5.5 2.1 2 1 0 2 2 1 0 Up-regulated During Septation PRKG1_interact PF15898.5 CCF34162.1 - 7 7.6 11.4 1.8 9.5 3.6 2.8 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain TPR_MLP1_2 PF07926.12 CCF34162.1 - 7.3 6.7 12.7 2.2 8.3 2.6 2.4 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein Pec_lyase_C PF00544.19 CCF34163.1 - 1.1e-22 80.7 9.9 1.3e-21 77.2 9.9 2.0 1 1 0 1 1 1 1 Pectate lyase Beta_helix PF13229.6 CCF34163.1 - 5.9e-07 29.5 21.6 9.5e-05 22.3 10.1 2.2 1 1 1 2 2 2 2 Right handed beta helix region MFS_1 PF07690.16 CCF34164.1 - 2.4e-21 76.0 74.4 4.9e-14 52.0 35.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Aminotran_3 PF00202.21 CCF34165.1 - 6.8e-98 328.0 0.1 8.5e-98 327.7 0.1 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 CCF34165.1 - 0.022 14.0 0.0 0.04 13.1 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class I and II Fungal_trans PF04082.18 CCF34166.1 - 0.029 13.4 0.0 0.043 12.9 0.0 1.2 1 0 0 1 1 1 0 Fungal specific transcription factor domain HTH_psq PF05225.16 CCF34167.1 - 2.1e-08 33.7 0.6 4.2e-08 32.8 0.1 1.8 2 0 0 2 2 2 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.16 CCF34167.1 - 6.7e-05 22.8 0.0 0.00014 21.8 0.0 1.6 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_AsnC-type PF13404.6 CCF34167.1 - 0.0037 17.1 0.1 0.014 15.2 0.1 1.9 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_23 PF13384.6 CCF34167.1 - 0.02 14.7 0.1 0.057 13.2 0.1 1.8 1 0 0 1 1 1 0 Homeodomain-like domain OrsD PF12013.8 CCF34168.1 - 6.3e-08 33.1 0.0 7.3e-08 32.8 0.0 1.1 1 0 0 1 1 1 1 Orsellinic acid/F9775 biosynthesis cluster protein D GAPT PF11770.8 CCF34169.1 - 0.056 13.3 0.0 0.094 12.6 0.0 1.3 1 0 0 1 1 1 0 GRB2-binding adapter (GAPT) Peptidase_M28 PF04389.17 CCF34170.1 - 7.3e-25 87.8 0.0 1e-24 87.3 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 CCF34170.1 - 6.7e-05 22.7 0.1 8.7e-05 22.3 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 ABC_tran PF00005.27 CCF34171.1 - 7.9e-47 159.2 0.0 4.1e-23 82.4 0.0 2.6 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 CCF34171.1 - 1.8e-19 70.7 0.8 0.00018 21.4 0.0 4.2 3 1 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system ABC_tran_Xtn PF12848.7 CCF34171.1 - 2.8e-19 68.9 1.1 2.8e-19 68.9 1.1 2.5 3 0 0 3 3 2 1 ABC transporter SMC_N PF02463.19 CCF34171.1 - 6.8e-12 45.3 0.2 0.00018 21.0 0.1 4.3 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CCF34171.1 - 1.4e-09 38.7 0.5 0.01 16.3 0.0 3.4 3 0 0 3 3 3 2 AAA domain AAA_29 PF13555.6 CCF34171.1 - 4.6e-09 35.9 0.0 0.0028 17.4 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_15 PF13175.6 CCF34171.1 - 5.4e-07 29.6 0.3 0.037 13.8 0.0 2.8 3 1 0 3 3 3 2 AAA ATPase domain RsgA_GTPase PF03193.16 CCF34171.1 - 3.8e-06 26.9 0.0 0.0083 16.0 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 CCF34171.1 - 4e-06 27.3 0.0 0.01 16.2 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain MMR_HSR1 PF01926.23 CCF34171.1 - 2.5e-05 24.3 0.0 0.025 14.6 0.0 2.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_22 PF13401.6 CCF34171.1 - 5.2e-05 23.5 0.0 0.074 13.3 0.1 2.6 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 CCF34171.1 - 0.00015 22.4 0.0 0.29 11.7 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_27 PF13514.6 CCF34171.1 - 0.00017 21.2 0.0 0.047 13.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 CCF34171.1 - 0.00031 21.0 0.0 0.14 12.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 CCF34171.1 - 0.00034 20.6 0.1 0.76 9.7 0.0 2.6 2 0 0 2 2 2 2 NACHT domain AAA_24 PF13479.6 CCF34171.1 - 0.00066 19.5 1.0 1.7 8.3 0.0 3.8 4 0 0 4 4 4 1 AAA domain AAA PF00004.29 CCF34171.1 - 0.00071 20.0 0.2 1.2 9.5 0.0 3.1 3 1 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CCF34171.1 - 0.00085 19.3 0.1 1.3 9.0 0.1 2.7 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 CCF34171.1 - 0.0014 19.0 0.0 3 8.3 0.0 2.8 2 0 0 2 2 2 2 RNA helicase Roc PF08477.13 CCF34171.1 - 0.0028 17.9 0.1 1.9 8.7 0.0 3.0 2 1 1 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase AAA_33 PF13671.6 CCF34171.1 - 0.0041 17.3 0.1 0.8 9.9 0.0 2.8 3 0 0 3 3 2 1 AAA domain AAA_14 PF13173.6 CCF34171.1 - 0.0079 16.2 0.0 1.6 8.8 0.0 2.7 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.22 CCF34171.1 - 0.0084 15.3 0.0 5 6.2 0.0 3.0 3 0 0 3 3 3 1 NB-ARC domain DUF2813 PF11398.8 CCF34171.1 - 0.017 14.4 0.5 3.7 6.7 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2813) AAA_7 PF12775.7 CCF34171.1 - 0.033 13.7 0.3 1.5 8.3 0.0 2.6 3 0 0 3 3 3 0 P-loop containing dynein motor region AAA_25 PF13481.6 CCF34171.1 - 0.034 13.7 0.1 0.97 9.0 0.0 2.9 3 1 0 3 3 3 0 AAA domain AAA_30 PF13604.6 CCF34171.1 - 0.041 13.6 0.1 3.6 7.3 0.0 2.9 2 1 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 CCF34171.1 - 0.076 12.9 0.1 2.8 7.8 0.0 2.5 2 0 0 2 2 2 0 NTPase AAA_17 PF13207.6 CCF34171.1 - 0.079 13.4 0.0 17 5.8 0.0 2.8 2 0 0 2 2 2 0 AAA domain DAP3 PF10236.9 CCF34171.1 - 0.09 11.9 0.1 7.2 5.7 0.0 2.6 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 PduV-EutP PF10662.9 CCF34171.1 - 0.13 12.0 0.2 6.8 6.4 0.0 2.9 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation DUF3584 PF12128.8 CCF34171.1 - 0.16 9.4 0.4 0.41 8.1 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) MARVEL PF01284.23 CCF34172.1 - 0.039 14.0 4.1 2.7 8.0 1.4 2.2 2 0 0 2 2 2 0 Membrane-associating domain DUF4064 PF13273.6 CCF34172.1 - 0.16 12.3 2.3 1.7 8.9 0.4 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) DUF4203 PF13886.6 CCF34172.1 - 3.1 7.4 9.7 0.59 9.8 3.8 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4203) Methyltransf_23 PF13489.6 CCF34173.1 - 2.9e-16 59.8 0.0 4.4e-16 59.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF34173.1 - 1.3e-08 35.4 0.0 4.2e-08 33.8 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF34173.1 - 3.3e-08 34.1 0.0 6.4e-08 33.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF34173.1 - 9.4e-07 29.5 0.0 5.8e-06 27.0 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCF34173.1 - 8.3e-06 25.3 0.0 1.4e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 CCF34173.1 - 0.00043 20.1 0.0 0.002 17.9 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain AAA PF00004.29 CCF34175.1 - 1.2e-46 158.4 0.0 3.4e-42 144.0 0.0 2.8 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CCF34175.1 - 4.5e-10 39.2 0.0 1.7e-09 37.3 0.0 1.9 2 0 0 2 2 1 1 AAA+ lid domain AAA_16 PF13191.6 CCF34175.1 - 3.2e-08 34.1 1.3 0.00086 19.7 0.3 3.7 3 1 0 3 3 3 2 AAA ATPase domain IstB_IS21 PF01695.17 CCF34175.1 - 1.9e-06 27.7 0.0 4.3e-05 23.3 0.0 2.4 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_2 PF07724.14 CCF34175.1 - 1e-05 25.7 0.0 2.6e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 CCF34175.1 - 7.5e-05 23.0 0.1 0.042 14.1 0.2 3.9 2 1 0 2 2 2 1 AAA domain AAA_5 PF07728.14 CCF34175.1 - 0.0013 18.7 0.0 0.0074 16.3 0.0 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 CCF34175.1 - 0.0034 17.6 6.9 0.024 14.8 0.0 4.2 4 0 0 4 4 4 1 AAA domain AAA_18 PF13238.6 CCF34175.1 - 0.0071 16.9 0.0 0.03 14.8 0.0 2.2 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 CCF34175.1 - 0.0091 16.4 0.0 0.066 13.6 0.0 2.4 2 0 0 2 2 2 1 RNA helicase TIP49 PF06068.13 CCF34175.1 - 0.0099 15.1 0.0 0.017 14.3 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain RuvB_N PF05496.12 CCF34175.1 - 0.018 14.8 0.0 0.044 13.5 0.0 1.6 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 CCF34175.1 - 0.039 14.0 0.0 0.11 12.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 CCF34175.1 - 0.046 14.0 0.0 0.14 12.4 0.0 1.9 1 0 0 1 1 1 0 AAA domain Torsin PF06309.11 CCF34175.1 - 0.047 13.8 0.0 1.6 8.8 0.0 2.4 2 0 0 2 2 2 0 Torsin Mg_chelatase PF01078.21 CCF34175.1 - 0.057 12.8 0.1 0.13 11.6 0.1 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Parvo_NS1 PF01057.17 CCF34175.1 - 0.076 12.1 0.2 0.24 10.4 0.0 1.8 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 AAA_3 PF07726.11 CCF34175.1 - 0.11 12.3 0.0 0.27 11.1 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 CCF34175.1 - 0.12 12.9 0.0 0.76 10.3 0.0 2.4 3 0 0 3 3 1 0 ABC transporter AAA_7 PF12775.7 CCF34175.1 - 0.12 11.8 0.0 0.38 10.2 0.0 1.8 1 0 0 1 1 1 0 P-loop containing dynein motor region Sigma54_activat PF00158.26 CCF34175.1 - 0.15 11.7 0.0 3.5 7.3 0.0 2.8 3 0 0 3 3 3 0 Sigma-54 interaction domain TsaE PF02367.17 CCF34175.1 - 0.17 11.9 0.0 0.45 10.5 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Haspin_kinase PF12330.8 CCF34176.1 - 1.1e-36 126.6 0.0 1.5e-36 126.1 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 CCF34176.1 - 0.039 13.9 0.1 0.082 12.8 0.1 1.6 1 1 0 1 1 1 0 Phosphotransferase enzyme family ARID PF01388.21 CCF34179.1 - 6e-18 65.3 0.9 3.2e-17 63.0 0.1 2.6 3 0 0 3 3 3 1 ARID/BRIGHT DNA binding domain zf-C2H2_3rep PF18868.1 CCF34179.1 - 0.025 15.3 0.2 0.062 14.0 0.2 1.6 1 0 0 1 1 1 0 Zinc finger C2H2-type, 3 repeats Arm PF00514.23 CCF34179.1 - 0.033 14.2 1.1 7.5 6.7 0.0 3.2 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat PGC7_Stella PF15549.6 CCF34179.1 - 0.034 14.1 0.1 0.13 12.2 0.0 2.0 2 0 0 2 2 2 0 PGC7/Stella/Dppa3 domain p450 PF00067.22 CCF34180.1 - 1.9e-05 23.6 0.0 2.1e-05 23.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 T5orf172 PF10544.9 CCF34181.1 - 2.8e-16 59.9 0.4 2.8e-16 59.9 0.4 2.4 3 0 0 3 3 3 1 T5orf172 domain MUG113 PF13455.6 CCF34181.1 - 1.9e-12 47.7 0.2 1.5e-11 44.8 0.1 2.4 2 0 0 2 2 2 1 Meiotically up-regulated gene 113 Ribosomal_L22 PF00237.19 CCF34181.1 - 0.13 12.5 0.0 0.3 11.4 0.0 1.6 1 0 0 1 1 1 0 Ribosomal protein L22p/L17e Phage_TTP_1 PF04630.12 CCF34182.1 - 0.1 11.9 0.0 0.14 11.4 0.0 1.2 1 0 0 1 1 1 0 Phage tail tube protein KAR9 PF08580.10 CCF34182.1 - 4.5 5.7 8.3 5.2 5.5 8.3 1.0 1 0 0 1 1 1 0 Yeast cortical protein KAR9 Glyco_transf_28 PF03033.20 CCF34185.1 - 6e-25 87.9 0.0 1.1e-24 87.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain UDPGT PF00201.18 CCF34185.1 - 0.016 14.0 0.1 0.039 12.7 0.1 1.6 1 1 0 1 1 1 0 UDP-glucoronosyl and UDP-glucosyl transferase RTA1 PF04479.13 CCF34186.1 - 2.3e-75 252.7 2.2 2.3e-75 252.7 2.2 1.4 2 0 0 2 2 2 1 RTA1 like protein Cation_ATPase_C PF00689.21 CCF34186.1 - 0.043 13.5 7.5 0.29 10.8 0.7 2.9 2 1 0 2 2 2 0 Cation transporting ATPase, C-terminus DUF3367 PF11847.8 CCF34186.1 - 0.088 10.7 0.0 0.13 10.1 0.0 1.1 1 0 0 1 1 1 0 Alpha-(1->3)-arabinofuranosyltransferase 7TMR-DISM_7TM PF07695.11 CCF34186.1 - 0.14 12.0 13.0 0.033 14.1 3.5 2.3 2 0 0 2 2 2 0 7TM diverse intracellular signalling DUF4173 PF13777.6 CCF34186.1 - 0.41 10.0 4.8 0.86 9.0 0.3 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4173) DUF2759 PF10958.8 CCF34186.1 - 0.93 9.3 7.8 0.68 9.7 1.3 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2759) DUF2207 PF09972.9 CCF34186.1 - 3 6.5 6.4 7.8 5.1 6.5 1.7 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF4131 PF13567.6 CCF34186.1 - 7.5 6.2 9.6 28 4.3 0.3 3.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) p450 PF00067.22 CCF34187.1 - 1.2e-48 166.1 0.1 1.5e-48 165.8 0.1 1.1 1 0 0 1 1 1 1 Cytochrome P450 F-box-like PF12937.7 CCF34188.1 - 0.28 11.1 0.1 0.28 11.1 0.1 2.2 3 0 0 3 3 3 0 F-box-like Hamartin PF04388.12 CCF34189.1 - 9e-24 84.2 3.8 9e-24 84.2 3.8 3.8 1 1 2 3 3 3 2 Hamartin protein Tuberin PF03542.16 CCF34189.1 - 0.012 14.7 0.1 0.028 13.6 0.1 1.5 1 0 0 1 1 1 0 Tuberin DUF1664 PF07889.12 CCF34189.1 - 1.7 8.7 15.6 2.7 8.0 1.8 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Macoilin PF09726.9 CCF34189.1 - 5.1 5.5 44.0 15 4.0 44.0 1.6 1 1 0 1 1 1 0 Macoilin family DJ-1_PfpI PF01965.24 CCF34190.1 - 1.5e-11 44.4 0.0 2.7e-11 43.6 0.0 1.4 1 0 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.5 CCF34190.1 - 0.027 14.2 0.0 0.036 13.8 0.0 1.2 1 0 0 1 1 1 0 ThiJ/PfpI family-like Vps39_1 PF10366.9 CCF34191.1 - 0.034 14.4 0.0 0.087 13.1 0.0 1.7 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 1 CASP_C PF08172.12 CCF34192.1 - 1.3e-95 319.5 17.2 4.8e-95 317.7 0.0 3.7 3 1 1 4 4 4 1 CASP C terminal SlyX PF04102.12 CCF34192.1 - 0.004 17.7 30.3 0.0047 17.5 0.0 6.6 7 0 0 7 7 7 2 SlyX TolA_bind_tri PF16331.5 CCF34192.1 - 0.0047 17.0 30.0 0.11 12.6 0.6 5.7 6 0 0 6 6 6 2 TolA binding protein trimerisation bZIP_2 PF07716.15 CCF34192.1 - 0.015 15.4 2.0 0.015 15.4 2.0 8.2 8 1 0 8 8 8 0 Basic region leucine zipper DUF1664 PF07889.12 CCF34192.1 - 0.1 12.6 0.1 0.1 12.6 0.1 6.0 4 2 1 6 6 6 0 Protein of unknown function (DUF1664) Fez1 PF06818.15 CCF34192.1 - 0.11 12.9 44.6 0.62 10.5 16.6 4.8 4 1 1 5 5 5 0 Fez1 PI3K_P85_iSH2 PF16454.5 CCF34192.1 - 0.13 11.9 35.5 0.067 12.8 2.2 4.6 2 1 1 4 4 4 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain DUF4407 PF14362.6 CCF34192.1 - 0.23 10.8 36.9 0.32 10.3 2.0 4.5 1 1 3 4 4 4 0 Domain of unknown function (DUF4407) IFP_35_N PF07334.13 CCF34192.1 - 0.3 11.2 0.0 0.3 11.2 0.0 4.6 4 0 0 4 4 4 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus FlaC_arch PF05377.11 CCF34192.1 - 0.6 10.6 34.7 0.31 11.5 0.2 6.8 6 1 1 7 7 7 0 Flagella accessory protein C (FlaC) WD40_alt PF14077.6 CCF34192.1 - 1.1 9.2 6.9 1.8 8.5 0.0 3.7 3 1 1 4 4 4 0 Alternative WD40 repeat motif GTP-bdg_M PF16360.5 CCF34192.1 - 1.2 9.8 0.0 1.2 9.8 0.0 5.1 4 1 0 4 4 4 0 GTP-binding GTPase Middle Region LPP PF04728.13 CCF34192.1 - 1.3 9.5 17.3 9 6.8 0.9 6.0 5 0 0 5 5 5 0 Lipoprotein leucine-zipper XRCC4 PF06632.12 CCF34192.1 - 1.5 7.6 23.6 0.014 14.3 8.5 3.0 2 1 1 3 3 3 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 Metal_resist PF13801.6 CCF34192.1 - 1.7 8.9 0.0 1.7 8.9 0.0 3.9 5 0 0 5 5 3 0 Heavy-metal resistance Filament PF00038.21 CCF34192.1 - 2.6 7.5 47.5 2.8 7.4 3.7 3.8 2 1 2 4 4 4 0 Intermediate filament protein APG6_N PF17675.1 CCF34192.1 - 3.2 8.3 61.1 5.6 7.5 0.3 6.0 2 1 3 5 5 5 0 Apg6 coiled-coil region HMMR_C PF15908.5 CCF34192.1 - 5.8 7.2 29.8 3.9 7.7 4.5 4.6 4 1 1 5 5 4 0 Hyaluronan mediated motility receptor C-terminal TPR_MLP1_2 PF07926.12 CCF34192.1 - 7.1 6.7 65.6 0.1 12.7 8.8 7.3 5 1 1 6 6 6 0 TPR/MLP1/MLP2-like protein YabA PF06156.13 CCF34192.1 - 7.2 7.3 36.0 1.1 10.0 0.0 6.1 2 1 3 6 6 6 0 Initiation control protein YabA Cep57_MT_bd PF06657.13 CCF34192.1 - 9.6 6.7 36.4 1.9 9.0 0.3 6.3 6 0 0 6 6 6 0 Centrosome microtubule-binding domain of Cep57 UPF0180 PF03698.13 CCF34193.1 - 0.015 15.5 0.0 0.046 13.9 0.0 1.8 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0180) DUF2999 PF11212.8 CCF34193.1 - 0.029 14.6 0.0 0.58 10.5 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2999) LRR_6 PF13516.6 CCF34193.1 - 0.24 11.5 13.2 7 7.0 0.9 5.7 6 0 0 6 6 6 0 Leucine Rich repeat LRR_1 PF00560.33 CCF34193.1 - 0.56 11.0 15.1 22 6.1 0.1 6.8 6 0 0 6 6 6 0 Leucine Rich Repeat LRR_4 PF12799.7 CCF34193.1 - 3.2 8.3 18.8 1 9.8 1.0 4.4 4 1 1 5 5 5 0 Leucine Rich repeats (2 copies) Sod_Fe_C PF02777.18 CCF34194.1 - 1e-33 115.5 0.6 1.8e-33 114.7 0.1 1.6 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 CCF34194.1 - 3.3e-30 104.4 4.4 3.3e-30 104.4 4.4 2.1 2 1 0 2 2 2 1 Iron/manganese superoxide dismutases, alpha-hairpin domain NmrA PF05368.13 CCF34196.1 - 1e-20 74.3 0.0 1.4e-20 73.9 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CCF34196.1 - 6.7e-15 55.4 0.0 3e-14 53.3 0.0 1.8 2 0 0 2 2 2 1 NAD(P)H-binding Epimerase PF01370.21 CCF34196.1 - 2.4e-08 33.7 0.1 1e-06 28.4 0.1 2.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 CCF34196.1 - 2.6e-05 24.2 0.1 4.2e-05 23.5 0.1 1.3 1 0 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.18 CCF34196.1 - 0.00084 19.6 0.1 0.0017 18.6 0.1 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain TrkA_N PF02254.18 CCF34196.1 - 0.0033 17.7 0.1 0.0074 16.5 0.1 1.6 1 0 0 1 1 1 1 TrkA-N domain Polysacc_synt_2 PF02719.15 CCF34196.1 - 0.0085 15.2 0.4 0.019 14.1 0.3 1.6 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein Shikimate_DH PF01488.20 CCF34196.1 - 0.024 14.7 0.1 0.045 13.8 0.1 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase adh_short PF00106.25 CCF34196.1 - 0.059 12.8 0.1 0.099 12.1 0.1 1.4 1 0 0 1 1 1 0 short chain dehydrogenase GDP_Man_Dehyd PF16363.5 CCF34196.1 - 0.097 12.0 0.0 0.31 10.4 0.0 1.8 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 CCF34196.1 - 0.13 11.4 0.5 0.4 9.8 0.3 1.7 1 1 1 2 2 2 0 Male sterility protein 3Beta_HSD PF01073.19 CCF34196.1 - 0.17 10.9 0.0 0.26 10.2 0.0 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family zf-C3HC4_3 PF13920.6 CCF34197.1 - 3.1e-06 26.9 9.9 4e-06 26.6 9.9 1.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CCF34197.1 - 3.5e-05 23.6 12.3 4.7e-05 23.2 12.3 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CCF34197.1 - 0.0025 17.7 13.1 0.0034 17.2 13.1 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CCF34197.1 - 0.0031 17.8 11.8 0.0042 17.4 11.8 1.2 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 CCF34197.1 - 0.71 9.8 11.4 1.1 9.2 11.4 1.3 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 DZR PF12773.7 CCF34197.1 - 1.1 9.4 7.4 9.2 6.4 7.9 2.0 1 1 0 1 1 1 0 Double zinc ribbon zf-RING_4 PF14570.6 CCF34197.1 - 1.7 8.5 9.5 4.2 7.2 9.6 1.6 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_5 PF14634.6 CCF34197.1 - 1.9 8.5 11.6 3.1 7.9 11.6 1.3 1 0 0 1 1 1 0 zinc-RING finger domain SWIB PF02201.18 CCF34198.1 - 6.7e-32 109.2 0.3 3.4e-31 107.0 0.1 2.0 2 0 0 2 2 2 1 SWIB/MDM2 domain DEK_C PF08766.11 CCF34198.1 - 7.7e-17 61.0 1.0 4.3e-16 58.6 0.6 2.1 2 0 0 2 2 2 1 DEK C terminal domain SRP54_N PF02881.19 CCF34198.1 - 0.46 10.7 3.0 1.6 9.0 0.2 2.8 3 0 0 3 3 3 0 SRP54-type protein, helical bundle domain DTHCT PF08070.11 CCF34198.1 - 0.68 10.7 19.2 0.074 13.8 3.1 2.4 1 1 1 2 2 2 0 DTHCT (NUC029) region XRCC4 PF06632.12 CCF34198.1 - 3.9 6.2 7.8 7.7 5.3 7.6 1.6 1 1 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 adh_short PF00106.25 CCF34199.1 - 5.7e-22 78.1 0.0 1.8e-20 73.3 0.0 2.0 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF34199.1 - 2.4e-12 46.9 0.0 3.8e-12 46.3 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF34199.1 - 3.9e-06 26.9 0.2 7.3e-06 26.0 0.2 1.5 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF34199.1 - 0.00016 21.2 0.0 0.00024 20.6 0.0 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family THF_DHG_CYH_C PF02882.19 CCF34199.1 - 0.0061 15.9 0.0 0.011 15.1 0.0 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain RmlD_sub_bind PF04321.17 CCF34199.1 - 0.075 12.1 0.0 0.12 11.5 0.0 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain GH131_N PF18271.1 CCF34200.1 - 2.2e-63 214.4 0.7 2.5e-63 214.1 0.7 1.0 1 0 0 1 1 1 1 Glycoside hydrolase 131 catalytic N-terminal domain NDT80_PhoG PF05224.12 CCF34201.1 - 1.1e-44 153.0 0.0 1.7e-44 152.3 0.0 1.3 1 0 0 1 1 1 1 NDT80 / PhoG like DNA-binding family Fe-ADH PF00465.19 CCF34202.1 - 3.2e-69 233.5 0.4 3.9e-69 233.2 0.4 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 CCF34202.1 - 3.7e-17 62.9 0.1 4.9e-17 62.5 0.1 1.1 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase ANAPC4_WD40 PF12894.7 CCF34203.1 - 9.3e-08 32.3 0.0 0.00085 19.6 0.0 3.8 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CCF34203.1 - 0.026 15.4 9.4 2.6 9.1 0.0 5.2 4 1 0 4 4 4 0 WD domain, G-beta repeat Serglycin PF04360.12 CCF34203.1 - 0.11 12.5 0.7 0.31 11.0 0.7 1.8 1 0 0 1 1 1 0 Serglycin CDC45 PF02724.14 CCF34203.1 - 0.79 7.9 5.8 1.1 7.5 5.8 1.1 1 0 0 1 1 1 0 CDC45-like protein Cwf_Cwc_15 PF04889.12 CCF34203.1 - 5.7 6.6 8.7 8.7 6.0 8.7 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Glyco_hydro_18 PF00704.28 CCF34204.1 - 8.5e-70 235.9 0.1 9.8e-70 235.7 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 GHL15 PF14885.6 CCF34204.1 - 0.00043 20.3 1.6 0.00052 20.1 0.2 1.8 2 0 0 2 2 2 1 Hypothetical glycosyl hydrolase family 15 DRIM PF07539.12 CCF34205.1 - 1.4e-204 681.0 4.0 1.4e-204 681.0 4.0 2.4 2 0 0 2 2 2 1 Down-regulated in metastasis HEAT PF02985.22 CCF34205.1 - 2.3 8.7 11.2 7.3 7.1 0.1 6.9 8 0 0 8 8 8 0 HEAT repeat CNOT11 PF10155.9 CCF34205.1 - 6.2 7.0 5.7 1.4e+02 2.7 0.8 4.1 4 0 0 4 4 4 0 CCR4-NOT transcription complex subunit 11 zf-DNL PF05180.12 CCF34206.1 - 4.4e-28 97.0 0.3 6e-28 96.6 0.3 1.2 1 0 0 1 1 1 1 DNL zinc finger JHY PF15261.6 CCF34206.1 - 0.099 13.4 0.3 0.16 12.7 0.3 1.3 1 0 0 1 1 1 0 Jhy protein C2 PF00168.30 CCF34207.1 - 1.2e-82 272.8 0.0 1.4e-23 83.1 0.0 5.4 5 0 0 5 5 5 5 C2 domain SMP_LBD PF17047.5 CCF34207.1 - 2e-05 24.1 0.0 3.8e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 Synaptotagmin-like mitochondrial-lipid-binding domain MLVIN_C PF18697.1 CCF34207.1 - 0.071 13.2 0.1 1.6 8.9 0.1 2.6 2 0 0 2 2 2 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain Proteasome PF00227.26 CCF34208.1 - 1.8e-46 158.0 0.1 2.1e-46 157.8 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit NIBRIN_BRCT_II PF16508.5 CCF34210.1 - 3.1e-37 127.5 0.0 1.3e-36 125.5 0.0 2.1 2 0 0 2 2 2 1 Second BRCT domain on Nijmegen syndrome breakage protein Trypan_PARP PF05887.11 CCF34210.1 - 1.8e-07 31.2 19.7 1.8e-07 31.2 19.7 3.2 3 1 1 4 4 4 1 Procyclic acidic repetitive protein (PARP) FHA PF00498.26 CCF34210.1 - 2.6e-07 30.9 0.0 6.2e-07 29.7 0.0 1.7 1 0 0 1 1 1 1 FHA domain RTT107_BRCT_5 PF16770.5 CCF34210.1 - 0.0045 16.9 0.0 0.013 15.4 0.0 1.8 1 0 0 1 1 1 1 Regulator of Ty1 transposition protein 107 BRCT domain Yop-YscD_cpl PF16697.5 CCF34210.1 - 0.055 13.8 0.0 0.62 10.4 0.0 2.5 1 1 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain LIG3_BRCT PF16759.5 CCF34210.1 - 0.14 12.4 0.1 0.92 9.8 0.0 2.4 2 0 0 2 2 2 0 DNA ligase 3 BRCT domain Mannosyl_trans PF05007.13 CCF34211.1 - 1.7e-76 257.6 14.0 2.2e-76 257.2 14.0 1.1 1 0 0 1 1 1 1 Mannosyltransferase (PIG-M) PIG-U PF06728.13 CCF34211.1 - 1.3e-08 34.3 14.0 1.7e-07 30.7 14.0 2.3 1 1 0 1 1 1 1 GPI transamidase subunit PIG-U GT87 PF09594.10 CCF34211.1 - 0.082 12.6 29.4 0.0061 16.3 23.4 2.4 2 1 0 2 2 2 0 Glycosyltransferase family 87 Translin PF01997.16 CCF34212.1 - 1.1e-55 188.8 0.1 1.4e-55 188.5 0.1 1.1 1 0 0 1 1 1 1 Translin family Baculo_PEP_C PF04513.12 CCF34212.1 - 0.022 14.8 0.1 0.047 13.7 0.0 1.5 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus FliJ PF02050.16 CCF34212.1 - 0.027 14.7 0.3 0.089 13.0 0.1 1.8 2 0 0 2 2 2 0 Flagellar FliJ protein NPV_P10 PF05531.12 CCF34212.1 - 0.037 14.5 0.1 0.57 10.7 0.0 2.3 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein LXG PF04740.12 CCF34212.1 - 0.07 12.8 0.1 0.12 12.0 0.1 1.3 1 0 0 1 1 1 0 LXG domain of WXG superfamily Senescence PF06911.12 CCF34212.1 - 0.17 12.2 0.0 0.22 11.8 0.0 1.2 1 0 0 1 1 1 0 Senescence-associated protein tRNA-synt_2 PF00152.20 CCF34213.1 - 1e-69 235.0 0.0 1.3e-69 234.8 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) RTA1 PF04479.13 CCF34216.1 - 2.5e-54 184.0 11.6 2.8e-54 183.9 11.6 1.0 1 0 0 1 1 1 1 RTA1 like protein HlyIII PF03006.20 CCF34216.1 - 0.072 12.8 7.8 0.12 12.1 7.8 1.4 1 1 0 1 1 1 0 Haemolysin-III related DUF485 PF04341.12 CCF34216.1 - 0.14 12.1 4.5 4.2 7.4 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function, DUF485 VPDSG-CTERM PF18205.1 CCF34216.1 - 0.2 11.5 3.4 1.4 8.8 0.6 3.0 2 0 0 2 2 2 0 VPDSG-CTERM motif UPF0121 PF03661.13 CCF34217.1 - 8.2e-07 28.7 0.0 9.4e-07 28.5 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0121) DSPc PF00782.20 CCF34218.1 - 8.2e-09 35.4 0.0 1.7e-08 34.4 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 CCF34218.1 - 0.00016 21.4 0.0 0.0003 20.4 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 CCF34218.1 - 0.02 14.9 0.0 0.035 14.1 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family Fungal_trans PF04082.18 CCF34219.1 - 0.0071 15.4 0.0 0.016 14.3 0.0 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain DUF725 PF05267.12 CCF34219.1 - 0.069 13.1 0.6 0.77 9.8 0.2 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF725) AAA PF00004.29 CCF34220.1 - 5.5e-19 68.9 0.0 8.7e-19 68.3 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CCF34220.1 - 0.0071 16.6 0.6 0.35 11.1 0.6 2.5 1 1 0 1 1 1 1 AAA domain MeaB PF03308.16 CCF34220.1 - 0.023 13.7 0.0 0.035 13.1 0.0 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_16 PF13191.6 CCF34220.1 - 0.056 13.8 0.5 0.12 12.8 0.5 1.6 1 1 0 1 1 1 0 AAA ATPase domain IstB_IS21 PF01695.17 CCF34220.1 - 0.1 12.3 0.0 0.29 10.9 0.0 1.6 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_5 PF07728.14 CCF34220.1 - 0.13 12.3 0.0 0.88 9.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Metallophos PF00149.28 CCF34221.1 - 3.6e-38 132.1 0.5 5.8e-38 131.4 0.5 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 CCF34221.1 - 0.049 14.1 0.1 0.099 13.1 0.1 1.5 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain DUF3112 PF11309.8 CCF34222.1 - 1.1e-15 57.7 5.2 4.9e-11 42.5 0.8 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF3112) PS_Dcarbxylase PF02666.15 CCF34224.1 - 1.3e-56 191.4 0.0 2.2e-56 190.6 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase C2 PF00168.30 CCF34224.1 - 1.6e-39 134.4 0.0 3.5e-18 65.8 0.0 2.8 2 0 0 2 2 2 2 C2 domain EF-hand_5 PF13202.6 CCF34224.1 - 0.0026 17.2 0.0 0.013 14.9 0.0 2.3 2 0 0 2 2 2 1 EF hand EF-hand_1 PF00036.32 CCF34224.1 - 0.0079 15.7 0.0 0.032 13.8 0.0 2.2 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 CCF34224.1 - 0.018 14.9 0.0 0.11 12.4 0.0 2.4 1 0 0 1 1 1 0 EF-hand domain ERp29 PF07749.12 CCF34224.1 - 0.47 11.4 2.7 1.3 9.9 0.5 2.8 2 1 1 3 3 3 0 Endoplasmic reticulum protein ERp29, C-terminal domain Abhydrolase_1 PF00561.20 CCF34225.1 - 5.4e-42 144.2 0.0 6.5e-42 143.9 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold NRBF2 PF08961.10 CCF34225.1 - 0.23 11.1 0.0 0.36 10.4 0.0 1.2 1 0 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator AA_kinase PF00696.28 CCF34226.1 - 4.2e-33 114.9 0.1 1.6e-32 113.0 0.0 1.9 2 0 0 2 2 2 1 Amino acid kinase family ACT_7 PF13840.6 CCF34226.1 - 3.9e-10 39.4 3.3 1.1e-09 38.0 3.1 1.9 2 0 0 2 2 2 1 ACT domain ACT PF01842.25 CCF34226.1 - 4.5e-05 23.1 0.3 0.00011 21.9 0.3 1.7 1 0 0 1 1 1 1 ACT domain Glyco_hydro_5_C PF18564.1 CCF34228.1 - 5.4e-22 78.1 0.0 1.2e-21 77.0 0.0 1.6 1 0 0 1 1 1 1 Glycoside hydrolase family 5 C-terminal domain Cellulase PF00150.18 CCF34228.1 - 1.8e-11 44.0 2.9 4.6e-09 36.1 2.9 2.5 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_42 PF02449.15 CCF34228.1 - 0.019 14.3 0.1 0.23 10.8 0.0 2.2 2 0 0 2 2 2 0 Beta-galactosidase Sugar_tr PF00083.24 CCF34229.1 - 2.6e-78 263.9 12.3 3.3e-78 263.6 12.3 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF34229.1 - 5.4e-12 45.3 42.1 4.9e-08 32.3 17.6 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily Phage_holin_Dp1 PF16938.5 CCF34229.1 - 1.1 9.5 6.3 0.5 10.6 0.1 3.1 3 0 0 3 3 3 0 Putative phage holin Dp-1 DUF4685 PF15737.5 CCF34230.1 - 0.5 10.8 4.8 8.3 6.9 0.0 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4685) 4HBT PF03061.22 CCF34233.1 - 9.6e-14 51.5 0.0 1.4e-13 51.0 0.0 1.2 1 0 0 1 1 1 1 Thioesterase superfamily DUF4442 PF14539.6 CCF34233.1 - 0.016 15.3 0.0 0.021 14.9 0.0 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4442) 4HBT_3 PF13622.6 CCF34233.1 - 0.033 14.4 0.0 0.036 14.3 0.0 1.1 1 0 0 1 1 1 0 Thioesterase-like superfamily Tfb2 PF03849.14 CCF34234.1 - 1.6e-97 326.7 0.0 1.8e-97 326.5 0.0 1.0 1 0 0 1 1 1 1 Transcription factor Tfb2 Herpes_capsid PF06112.11 CCF34234.1 - 1.6 8.8 5.2 25 4.9 5.5 2.2 2 0 0 2 2 2 0 Gammaherpesvirus capsid protein IMPDH PF00478.25 CCF34235.1 - 1.5e-128 428.7 2.0 1.7e-128 428.5 2.0 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.28 CCF34235.1 - 5.3e-14 52.4 0.1 3.5e-06 27.4 0.0 2.5 2 0 0 2 2 2 2 CBS domain FMN_dh PF01070.18 CCF34235.1 - 4.1e-11 42.5 0.7 5.7e-09 35.5 0.7 2.2 2 0 0 2 2 2 2 FMN-dependent dehydrogenase NMO PF03060.15 CCF34235.1 - 3.8e-09 36.4 2.0 0.002 17.6 2.0 2.3 2 0 0 2 2 2 2 Nitronate monooxygenase His_biosynth PF00977.21 CCF34235.1 - 0.00019 21.0 4.3 0.026 14.0 0.3 3.1 3 1 1 4 4 4 2 Histidine biosynthesis protein YpsA PF06908.11 CCF34235.1 - 0.039 14.0 0.2 0.094 12.7 0.0 1.7 2 0 0 2 2 2 0 YspA SLOG family ThiG PF05690.14 CCF34235.1 - 0.058 12.7 2.9 0.17 11.1 0.6 2.4 1 1 2 3 3 3 0 Thiazole biosynthesis protein ThiG PK PF00224.21 CCF34235.1 - 0.098 11.5 0.0 0.37 9.6 0.0 1.8 1 1 1 2 2 2 0 Pyruvate kinase, barrel domain IQ PF00612.27 CCF34236.1 - 1.8e-14 52.1 20.1 0.016 15.0 0.1 11.3 12 0 0 12 12 12 5 IQ calmodulin-binding motif CH PF00307.31 CCF34236.1 - 3.1e-11 43.4 0.0 6.2e-11 42.4 0.0 1.4 1 0 0 1 1 1 1 Calponin homology (CH) domain AAA_13 PF13166.6 CCF34236.1 - 0.24 10.0 5.2 0.68 8.5 1.5 2.1 2 0 0 2 2 2 0 AAA domain Stc1 PF12898.7 CCF34238.1 - 2.3e-20 72.9 3.5 3.8e-20 72.2 1.2 2.2 2 0 0 2 2 2 1 Stc1 domain BPL_LplA_LipB PF03099.19 CCF34238.1 - 0.29 11.0 1.6 2.3 8.1 0.2 2.2 1 1 1 2 2 2 0 Biotin/lipoate A/B protein ligase family BCDHK_Adom3 PF10436.9 CCF34239.1 - 6.9e-76 253.6 0.0 1e-75 253.0 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 CCF34239.1 - 3.5e-10 40.4 0.0 6.3e-10 39.5 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 CCF34239.1 - 0.075 12.9 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF5089 PF17002.5 CCF34240.1 - 0.046 13.6 2.2 0.094 12.6 2.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5089) Com_YlbF PF06133.11 CCF34240.1 - 0.16 12.6 6.1 0.11 13.2 3.9 1.8 2 1 0 2 2 2 0 Control of competence regulator ComK, YlbF/YmcA Spc24 PF08286.11 CCF34240.1 - 2.2 8.6 6.8 7.6 6.8 5.6 2.2 2 1 0 2 2 2 0 Spc24 subunit of Ndc80 DUF5562 PF17717.1 CCF34242.1 - 0.025 14.6 3.9 0.039 13.9 3.9 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5562) MFS_1 PF07690.16 CCF34243.1 - 1.1e-17 64.1 42.6 1.3e-09 37.4 26.7 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 CCF34243.1 - 1.7e-10 40.0 17.8 3.5e-10 38.9 17.8 1.5 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) RabGAP-TBC PF00566.18 CCF34244.1 - 1.9e-48 165.0 0.1 1e-47 162.5 0.1 1.9 1 1 0 1 1 1 1 Rab-GTPase-TBC domain RRM_1 PF00076.22 CCF34246.1 - 4.1e-35 119.4 0.2 1.2e-16 60.3 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CCF34246.1 - 1.5e-10 41.1 0.2 0.00049 20.2 0.0 2.9 2 0 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.6 CCF34246.1 - 3.2e-05 23.8 0.0 0.35 10.9 0.0 2.4 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif TFIIA PF03153.13 CCF34246.1 - 0.087 12.8 29.1 0.14 12.1 29.1 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RRM_3 PF08777.11 CCF34246.1 - 0.098 12.7 1.1 17 5.5 0.0 2.8 3 0 0 3 3 3 0 RNA binding motif DHHC PF01529.20 CCF34248.1 - 0.13 12.4 0.8 0.19 11.9 0.8 1.2 1 0 0 1 1 1 0 DHHC palmitoyltransferase GMC_oxred_C PF05199.13 CCF34249.1 - 1.4e-15 58.1 0.0 1.6e-15 57.9 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase Asn_synthase PF00733.21 CCF34250.1 - 2.1e-65 221.7 0.1 4.1e-65 220.8 0.1 1.4 1 0 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.6 CCF34250.1 - 1e-33 115.9 0.0 3.8e-33 114.0 0.0 1.9 2 0 0 2 2 2 1 Glutamine amidotransferase domain GATase_6 PF13522.6 CCF34250.1 - 3.6e-30 104.9 0.1 1.4e-29 103.0 0.0 2.0 2 0 0 2 2 2 1 Glutamine amidotransferase domain DUF3700 PF12481.8 CCF34250.1 - 5.6e-05 22.7 0.5 0.00034 20.1 0.0 2.2 3 0 0 3 3 3 1 Aluminium induced protein NAD_synthase PF02540.17 CCF34250.1 - 0.063 12.4 0.0 0.1 11.7 0.0 1.3 1 0 0 1 1 1 0 NAD synthase Cwf_Cwc_15 PF04889.12 CCF34250.1 - 0.083 12.6 4.7 0.14 11.9 4.7 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CENP-B_dimeris PF09026.10 CCF34250.1 - 0.096 13.1 5.6 0.19 12.1 5.6 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain PYST-C1 PF09690.10 CCF34250.1 - 0.86 9.4 6.4 1.8 8.4 6.4 1.5 1 0 0 1 1 1 0 Plasmodium yoelii subtelomeric region (PYST-C1) Clathrin PF00637.20 CCF34251.1 - 6.5e-13 48.8 1.4 7.8e-09 35.5 0.1 2.8 3 0 0 3 3 3 2 Region in Clathrin and VPS zf-C3HC4_2 PF13923.6 CCF34251.1 - 0.00015 21.5 0.6 0.00039 20.2 0.6 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) DUF2175 PF09943.9 CCF34251.1 - 0.00028 21.1 0.2 0.00093 19.5 0.1 1.9 2 0 0 2 2 1 1 Uncharacterized protein conserved in archaea (DUF2175) zf-RING_5 PF14634.6 CCF34251.1 - 0.00052 19.9 0.4 0.00052 19.9 0.4 1.9 2 0 0 2 2 2 1 zinc-RING finger domain Zn_ribbon_17 PF17120.5 CCF34251.1 - 0.00063 19.3 0.1 0.0015 18.1 0.1 1.6 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-RING_2 PF13639.6 CCF34251.1 - 0.0039 17.5 0.5 0.0039 17.5 0.5 1.9 2 0 0 2 2 1 1 Ring finger domain zf-RING_UBOX PF13445.6 CCF34251.1 - 0.0047 16.9 0.6 0.013 15.5 0.6 1.7 1 0 0 1 1 1 1 RING-type zinc-finger Vps39_2 PF10367.9 CCF34251.1 - 0.023 15.1 0.0 0.065 13.7 0.0 1.8 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 zf-C3H2C3 PF17122.5 CCF34251.1 - 0.024 14.7 2.5 0.024 14.7 2.5 2.1 2 0 0 2 2 2 0 Zinc-finger zf-RING_11 PF17123.5 CCF34251.1 - 0.025 14.3 4.3 0.025 14.3 4.3 2.3 2 0 0 2 2 2 0 RING-like zinc finger zf-rbx1 PF12678.7 CCF34251.1 - 0.06 13.6 0.2 0.16 12.3 0.2 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain E2R135 PF11570.8 CCF34251.1 - 0.068 13.5 0.4 0.49 10.7 0.1 2.2 2 0 0 2 2 2 0 Coiled-coil receptor-binding R-domain of colicin E2 zf-C3HC4 PF00097.25 CCF34251.1 - 0.12 12.2 0.2 0.12 12.2 0.2 2.2 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) adh_short_C2 PF13561.6 CCF34253.1 - 1.2e-50 172.3 0.1 1.4e-50 172.1 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF34253.1 - 1.5e-49 168.1 0.1 1.8e-49 167.8 0.1 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF34253.1 - 3.4e-14 53.2 1.2 7.1e-14 52.1 1.2 1.6 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF34253.1 - 2.7e-05 23.8 0.2 4.7e-05 23.0 0.1 1.5 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CCF34253.1 - 0.0044 16.4 0.2 0.0065 15.9 0.2 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Exotox-A_cataly PF09009.10 CCF34253.1 - 0.0069 16.1 0.2 0.013 15.3 0.2 1.4 1 0 0 1 1 1 1 Exotoxin A catalytic Glyco_transf_5 PF08323.11 CCF34253.1 - 0.0091 15.7 0.1 0.17 11.5 0.0 2.3 2 1 1 3 3 3 1 Starch synthase catalytic domain Glyco_trans_4_4 PF13579.6 CCF34253.1 - 0.15 12.5 1.1 11 6.5 0.1 2.4 3 0 0 3 3 3 0 Glycosyl transferase 4-like domain MR_MLE_C PF13378.6 CCF34254.1 - 7.8e-41 140.0 0.2 2.5e-21 76.2 0.0 2.1 1 1 1 2 2 2 2 Enolase C-terminal domain-like MR_MLE_N PF02746.16 CCF34254.1 - 3.9e-21 75.4 0.0 7.3e-21 74.6 0.0 1.4 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain MFS_1 PF07690.16 CCF34255.1 - 6.8e-53 179.8 37.1 9.6e-52 176.0 37.0 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF34255.1 - 1.4e-11 43.9 9.5 1.4e-11 43.9 9.5 2.4 2 1 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 CCF34255.1 - 6.8e-11 41.3 20.4 9.7e-11 40.8 20.2 1.4 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.20 CCF34255.1 - 0.029 12.7 13.5 0.021 13.2 2.7 3.0 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family DUF4245 PF14030.6 CCF34255.1 - 0.15 12.0 0.8 1.7 8.6 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4245) DUF1129 PF06570.11 CCF34255.1 - 2.3 7.7 8.9 1.4 8.4 1.2 3.0 2 1 0 3 3 3 0 Protein of unknown function (DUF1129) Pkinase PF00069.25 CCF34256.1 - 1.3e-26 93.6 0.1 1.5e-26 93.4 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF34256.1 - 2.5e-17 63.0 0.0 3.1e-17 62.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Glycos_transf_2 PF00535.26 CCF34256.1 - 0.15 11.8 0.0 0.17 11.7 0.0 1.1 1 0 0 1 1 1 0 Glycosyl transferase family 2 Transglut_core PF01841.19 CCF34257.1 - 4.8e-11 43.1 0.4 1.3e-10 41.7 0.4 1.8 1 0 0 1 1 1 1 Transglutaminase-like superfamily SH3_2 PF07653.17 CCF34257.1 - 7.9e-09 35.1 0.3 1.6e-08 34.1 0.3 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 CCF34257.1 - 0.00011 21.8 0.2 0.00011 21.8 0.2 2.3 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 CCF34257.1 - 0.016 15.1 0.3 0.034 14.0 0.3 1.6 1 0 0 1 1 1 0 Variant SH3 domain DUF883 PF05957.13 CCF34258.1 - 0.66 10.6 7.9 13 6.5 4.9 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) Ribosomal_L32e PF01655.18 CCF34260.1 - 1.9e-49 166.6 1.0 1.9e-49 166.6 1.0 1.4 1 1 1 2 2 2 1 Ribosomal protein L32 PTCB-BRCT PF12738.7 CCF34262.1 - 5.1e-45 151.3 0.0 9.5e-21 73.5 0.0 3.4 3 0 0 3 3 3 3 twin BRCT domain BRCT PF00533.26 CCF34262.1 - 4.6e-34 116.6 0.0 5.1e-11 42.8 0.0 4.6 4 1 0 4 4 4 3 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 CCF34262.1 - 1.5e-18 66.9 0.0 0.00015 22.1 0.0 4.4 4 0 0 4 4 4 3 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 CCF34262.1 - 4.9e-08 33.1 0.3 0.1 12.9 0.0 3.5 3 0 0 3 3 3 2 DNA ligase 3 BRCT domain BRCT_3 PF18428.1 CCF34262.1 - 1.2e-06 28.5 0.1 0.026 14.6 0.0 3.5 3 0 0 3 3 3 2 BRCA1 C Terminus (BRCT) domain SAC3_GANP PF03399.16 CCF34263.1 - 5.3e-25 88.4 1.2 6.6e-23 81.5 1.3 2.1 1 1 0 1 1 1 1 SAC3/GANP family CSN8_PSD8_EIF3K PF10075.9 CCF34263.1 - 0.11 12.5 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 CSN8/PSMD8/EIF3K family EAP30 PF04157.16 CCF34264.1 - 7.6e-43 146.5 0.1 9.9e-43 146.1 0.1 1.2 1 0 0 1 1 1 1 EAP30/Vps36 family Vps36_ESCRT-II PF11605.8 CCF34264.1 - 2.9e-22 78.6 0.0 4.8e-22 78.0 0.0 1.3 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 Vps36-NZF-N PF16988.5 CCF34264.1 - 3.3e-22 77.6 2.3 3.3e-22 77.6 2.3 2.7 2 1 0 2 2 2 1 Vacuolar protein sorting 36 NZF-N zinc-finger domain zf-Sec23_Sec24 PF04810.15 CCF34264.1 - 0.00056 19.9 3.9 0.029 14.4 0.2 2.4 2 0 0 2 2 2 2 Sec23/Sec24 zinc finger GRAM PF02893.20 CCF34264.1 - 0.0073 16.2 0.0 0.013 15.3 0.0 1.3 1 0 0 1 1 1 1 GRAM domain zf-RanBP PF00641.18 CCF34264.1 - 0.0092 15.3 12.9 0.012 14.9 0.8 2.7 3 0 0 3 3 3 2 Zn-finger in Ran binding protein and others DZR PF12773.7 CCF34264.1 - 1.5 8.9 6.4 0.32 11.1 1.3 2.2 2 0 0 2 2 2 0 Double zinc ribbon RAI16-like PF10257.9 CCF34265.1 - 7e-74 248.9 1.9 9.2e-74 248.5 1.9 1.1 1 0 0 1 1 1 1 Retinoic acid induced 16-like protein RhoGEF PF00621.20 CCF34266.1 - 2.3e-32 112.7 0.9 3.6e-32 112.1 0.9 1.3 1 0 0 1 1 1 1 RhoGEF domain Mito_carr PF00153.27 CCF34267.1 - 4.7e-61 202.7 1.1 2.7e-21 75.3 0.3 3.3 3 1 0 3 3 3 3 Mitochondrial carrier protein SPRY PF00622.28 CCF34268.1 - 0.0018 18.4 0.0 0.024 14.8 0.0 2.7 3 0 0 3 3 3 1 SPRY domain PHINT_rpt PF14882.6 CCF34269.1 - 0.19 12.0 2.1 0.47 10.8 1.6 2.0 2 0 0 2 2 2 0 Phage-integrase repeat unit SMC_Nse1 PF07574.13 CCF34270.1 - 2e-73 246.4 0.7 2.7e-73 246.0 0.7 1.1 1 0 0 1 1 1 1 Nse1 non-SMC component of SMC5-6 complex zf-RING-like PF08746.11 CCF34270.1 - 8.8e-15 54.7 12.9 1.4e-14 54.1 12.9 1.3 1 0 0 1 1 1 1 RING-like domain FadR_C PF07840.12 CCF34270.1 - 0.021 14.7 0.1 0.035 14.0 0.1 1.3 1 0 0 1 1 1 0 FadR C-terminal domain Mrr_N PF14338.6 CCF34270.1 - 0.038 14.1 0.0 5.4 7.2 0.0 2.6 2 0 0 2 2 2 0 Mrr N-terminal domain ANAPC2 PF08672.11 CCF34270.1 - 0.062 13.8 0.2 5.3 7.6 0.1 2.8 3 0 0 3 3 3 0 Anaphase promoting complex (APC) subunit 2 zf-RING_2 PF13639.6 CCF34270.1 - 2.3 8.6 9.3 4.1 7.8 9.3 1.4 1 0 0 1 1 1 0 Ring finger domain DUF2303 PF10065.9 CCF34271.1 - 0.16 11.1 0.1 0.24 10.5 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2303) Clr2 PF10383.9 CCF34272.1 - 2.2e-11 44.7 1.0 1.1e-10 42.5 0.0 2.6 2 1 0 2 2 2 1 Transcription-silencing protein Clr2 Clr2_transil PF16761.5 CCF34272.1 - 9.8e-09 35.9 1.2 2.9e-08 34.4 1.2 1.8 1 1 0 1 1 1 1 Transcription-silencing protein, cryptic loci regulator Clr2 TFIIA PF03153.13 CCF34272.1 - 0.19 11.7 19.3 0.31 11.0 19.3 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CAP59_mtransfer PF11735.8 CCF34275.1 - 3.3e-62 210.3 0.0 4.3e-62 210.0 0.0 1.1 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 DUF3827 PF12877.7 CCF34276.1 - 0.89 7.9 9.8 1.1 7.6 9.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) Methyltransf_25 PF13649.6 CCF34277.1 - 8.1e-16 58.5 0.0 1.4e-15 57.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCF34277.1 - 9.5e-16 57.8 0.0 1.4e-15 57.3 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.12 CCF34277.1 - 1.4e-15 57.7 0.0 2.3e-15 57.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF34277.1 - 2.5e-11 43.6 0.0 3.5e-11 43.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF34277.1 - 4.5e-09 36.3 0.0 7.9e-09 35.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF34277.1 - 8.8e-07 29.6 0.0 1.3e-06 29.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 CCF34277.1 - 1.8e-05 24.7 0.0 3.6e-05 23.7 0.0 1.4 1 1 0 1 1 1 1 Hypothetical methyltransferase MTS PF05175.14 CCF34277.1 - 9.6e-05 22.0 0.1 0.00016 21.2 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase small domain MetW PF07021.12 CCF34277.1 - 0.0035 17.0 0.0 0.013 15.1 0.0 1.8 1 1 0 1 1 1 1 Methionine biosynthesis protein MetW PCMT PF01135.19 CCF34277.1 - 0.19 11.4 0.0 0.32 10.7 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Lipocalin_5 PF13924.6 CCF34278.1 - 3e-27 95.1 0.0 3.4e-27 95.0 0.0 1.0 1 0 0 1 1 1 1 Lipocalin-like domain zf-C2H2_2 PF12756.7 CCF34279.1 - 9.8e-27 93.3 1.7 2e-26 92.3 1.7 1.5 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 CCF34279.1 - 0.3 12.0 2.8 10 7.2 0.1 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger Gluconate_2-dh3 PF13618.6 CCF34279.1 - 1.7 8.9 4.1 28 5.0 0.8 2.3 1 1 1 2 2 2 0 Gluconate 2-dehydrogenase subunit 3 DUF1989 PF09347.10 CCF34280.1 - 1.8e-63 213.1 0.0 2.3e-63 212.8 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1989) Cse1 PF08506.10 CCF34281.1 - 8.7e-09 34.7 0.1 5.4e-08 32.1 0.0 2.1 1 1 0 2 2 2 1 Cse1 Vac14_Fab1_bd PF12755.7 CCF34281.1 - 0.0035 17.9 1.0 4.6 7.9 0.0 4.1 3 0 0 3 3 3 1 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 CCF34281.1 - 0.1 12.6 0.9 0.33 11.0 0.1 2.2 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 Metal_resist PF13801.6 CCF34281.1 - 0.23 11.6 4.7 0.77 10.0 4.4 2.0 2 0 0 2 2 2 0 Heavy-metal resistance WH2 PF02205.20 CCF34283.1 - 0.0078 16.0 0.0 0.013 15.3 0.0 1.4 1 0 0 1 1 1 1 WH2 motif eIF-1a PF01176.19 CCF34284.1 - 1.1e-21 76.3 0.1 1.6e-21 75.9 0.1 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 fn3_2 PF16893.5 CCF34286.1 - 2.3e-39 133.4 0.0 3.8e-39 132.7 0.0 1.3 1 0 0 1 1 1 1 Fibronectin type III domain CHS5_N PF16892.5 CCF34286.1 - 2.1e-23 82.0 0.8 3.3e-23 81.4 0.8 1.3 1 0 0 1 1 1 1 Chitin biosynthesis protein CHS5 N-terminus PTCB-BRCT PF12738.7 CCF34286.1 - 8.4e-13 48.1 0.0 1.6e-12 47.2 0.0 1.5 1 0 0 1 1 1 1 twin BRCT domain BRCT PF00533.26 CCF34286.1 - 5.3e-12 46.0 0.0 9.4e-12 45.2 0.0 1.4 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 CCF34286.1 - 5.9e-07 29.8 0.0 1.9e-06 28.2 0.0 1.9 1 1 1 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain fn3 PF00041.21 CCF34286.1 - 0.0015 18.8 0.0 0.0051 17.1 0.0 1.9 1 1 0 1 1 1 1 Fibronectin type III domain DUF3006 PF11213.8 CCF34286.1 - 0.0076 16.5 0.0 0.025 14.8 0.0 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF3006) PPP4R2 PF09184.11 CCF34286.1 - 1.3 8.5 12.9 1.8 8.1 12.9 1.1 1 0 0 1 1 1 0 PPP4R2 adh_short PF00106.25 CCF34287.1 - 2.5e-10 40.2 0.0 4.2e-05 23.1 0.0 2.5 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCF34287.1 - 1.3e-09 38.0 0.0 2.1e-06 27.5 0.0 2.2 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF34287.1 - 4.9e-05 23.3 0.0 7.3e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_4 PF07993.12 CCF34287.1 - 0.0013 17.9 0.0 0.0087 15.3 0.0 1.9 2 0 0 2 2 2 1 Male sterility protein NAD_binding_10 PF13460.6 CCF34287.1 - 0.15 12.0 2.4 0.41 10.5 2.4 1.7 1 1 0 1 1 1 0 NAD(P)H-binding Epimerase PF01370.21 CCF34287.1 - 0.19 11.1 0.1 0.3 10.5 0.1 1.5 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family p450 PF00067.22 CCF34289.1 - 2.9e-75 253.8 0.2 4.2e-75 253.3 0.2 1.1 1 0 0 1 1 1 1 Cytochrome P450 Ank_2 PF12796.7 CCF34291.1 - 1.3e-36 125.0 0.5 3.3e-10 40.4 0.0 5.4 2 1 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CCF34291.1 - 6.4e-24 81.4 0.1 0.0023 18.3 0.0 7.8 7 0 0 7 7 7 7 Ankyrin repeat Ank_4 PF13637.6 CCF34291.1 - 3.7e-23 81.6 1.1 4.4e-06 27.1 0.0 5.9 3 2 2 6 6 6 4 Ankyrin repeats (many copies) Ank PF00023.30 CCF34291.1 - 9.7e-22 76.4 0.2 0.00011 22.5 0.0 7.4 7 0 0 7 7 7 4 Ankyrin repeat Ank_5 PF13857.6 CCF34291.1 - 2.1e-18 66.2 0.0 1.8e-05 24.9 0.0 6.0 3 2 3 6 6 6 4 Ankyrin repeats (many copies) DUF2011 PF09428.10 CCF34291.1 - 0.14 12.4 0.0 0.32 11.3 0.0 1.5 1 0 0 1 1 1 0 Fungal protein of unknown function (DUF2011) FtsJ PF01728.19 CCF34292.1 - 6.4e-14 52.5 0.0 8.9e-14 52.0 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase SPO22 PF08631.10 CCF34294.1 - 1e-78 264.6 7.8 3.4e-74 249.8 0.1 3.9 5 0 0 5 5 5 3 Meiosis protein SPO22/ZIP4 like TPR_2 PF07719.17 CCF34294.1 - 0.14 12.3 2.0 1.4 9.3 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 CCF34294.1 - 0.62 10.6 7.4 0.13 12.8 0.7 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat Pyridoxal_deC PF00282.19 CCF34295.1 - 1.6e-78 264.1 0.0 2e-78 263.7 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain DegT_DnrJ_EryC1 PF01041.17 CCF34295.1 - 0.023 14.0 0.0 0.052 12.9 0.0 1.5 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family DUF4431 PF14485.6 CCF34295.1 - 0.14 12.0 0.0 1.1 9.1 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4431) Lactamase_B PF00753.27 CCF34296.1 - 5e-18 65.8 0.6 8.9e-18 65.0 0.6 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CCF34296.1 - 0.0027 17.2 0.0 0.0045 16.5 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Sulf_transp PF04143.14 CCF34297.1 - 6.6e-30 104.7 30.0 8.9e-30 104.3 29.5 1.5 1 1 0 1 1 1 1 Sulphur transport Ribonuc_L-PSP PF01042.21 CCF34298.1 - 8.1e-27 93.6 0.8 8.9e-27 93.5 0.8 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP DUF1320 PF07030.12 CCF34298.1 - 0.042 14.0 0.1 0.058 13.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1320) BID PF06393.11 CCF34298.1 - 0.13 11.8 0.0 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 BH3 interacting domain (BID) SAP PF02037.27 CCF34299.1 - 4.2e-08 32.7 0.4 6.9e-08 32.1 0.4 1.4 1 0 0 1 1 1 1 SAP domain zf-RING_2 PF13639.6 CCF34299.1 - 0.0079 16.5 13.7 0.0079 16.5 13.7 2.1 2 0 0 2 2 2 1 Ring finger domain PHD PF00628.29 CCF34299.1 - 0.031 14.2 12.2 0.13 12.2 12.4 1.9 1 1 1 2 2 2 0 PHD-finger Rad50_zn_hook PF04423.14 CCF34299.1 - 0.27 11.1 3.2 1.4 8.8 0.8 2.6 2 0 0 2 2 2 0 Rad50 zinc hook motif Aminotran_1_2 PF00155.21 CCF34300.1 - 1.9e-60 204.9 0.0 2.6e-60 204.5 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 CCF34300.1 - 0.24 10.7 0.0 0.4 9.9 0.0 1.3 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Sugar_tr PF00083.24 CCF34302.1 - 3.5e-79 266.8 21.9 4.2e-79 266.5 21.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF34302.1 - 4.4e-24 85.1 49.6 2.2e-22 79.5 27.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Peptidase_A4 PF01828.17 CCF34303.1 - 8.2e-71 237.8 14.6 9.7e-71 237.5 14.6 1.1 1 0 0 1 1 1 1 Peptidase A4 family Arteri_nucleo PF01481.16 CCF34303.1 - 0.041 14.2 0.0 0.072 13.4 0.0 1.3 1 0 0 1 1 1 0 Arterivirus nucleocapsid protein CARDB PF07705.11 CCF34303.1 - 0.059 13.6 0.5 0.23 11.7 0.3 2.2 1 1 1 2 2 2 0 CARDB HLH PF00010.26 CCF34306.1 - 4.5e-12 45.7 0.0 2e-11 43.7 0.0 2.0 1 1 0 1 1 1 1 Helix-loop-helix DNA-binding domain NPR3 PF03666.13 CCF34307.1 - 2.3e-147 491.6 0.1 3.5e-147 491.0 0.1 1.3 1 0 0 1 1 1 1 Nitrogen Permease regulator of amino acid transport activity 3 ATHILA PF03078.15 CCF34307.1 - 0.078 11.8 4.3 0.13 11.1 4.3 1.2 1 0 0 1 1 1 0 ATHILA ORF-1 family ERp29 PF07749.12 CCF34307.1 - 1 10.3 9.4 0.22 12.5 1.9 2.6 2 0 0 2 2 2 0 Endoplasmic reticulum protein ERp29, C-terminal domain WD40 PF00400.32 CCF34308.1 - 3e-11 43.7 1.6 0.00018 22.3 0.0 4.0 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF34308.1 - 0.028 14.7 0.0 1.5 9.2 0.0 2.8 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 CCF34308.1 - 0.054 13.1 0.0 0.52 9.9 0.0 2.2 1 1 0 2 2 2 0 PQQ-like domain PALB2_WD40 PF16756.5 CCF34308.1 - 0.068 12.1 0.0 0.19 10.6 0.0 1.5 1 1 0 1 1 1 0 Partner and localizer of BRCA2 WD40 domain ELO PF01151.18 CCF34310.1 - 7.8e-59 199.2 12.0 9.8e-59 198.9 12.0 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family 4HBT_2 PF13279.6 CCF34311.1 - 1.4e-09 38.5 0.0 3.3e-09 37.3 0.0 1.5 1 1 0 1 1 1 1 Thioesterase-like superfamily MFS_1 PF07690.16 CCF34312.1 - 1.2e-14 54.1 16.1 1.7e-14 53.5 16.1 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF34312.1 - 5e-07 29.0 1.9 7e-07 28.5 1.9 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter Cwf_Cwc_15 PF04889.12 CCF34312.1 - 1.6 8.4 15.3 0.78 9.4 10.8 2.0 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Abhydrolase_3 PF07859.13 CCF34314.1 - 6.1e-56 189.6 0.0 8.6e-56 189.1 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CCF34314.1 - 0.00055 19.5 0.0 0.083 12.4 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family COesterase PF00135.28 CCF34314.1 - 0.00058 18.9 0.2 0.0015 17.5 0.2 1.5 1 1 0 1 1 1 1 Carboxylesterase family Esterase_phd PF10503.9 CCF34314.1 - 0.0029 17.1 0.5 0.0049 16.4 0.5 1.3 1 0 0 1 1 1 1 Esterase PHB depolymerase Peptidase_S15 PF02129.18 CCF34314.1 - 0.12 11.9 0.1 0.33 10.5 0.0 1.6 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_6 PF12697.7 CCF34314.1 - 0.21 12.2 12.0 0.042 14.5 7.6 1.9 1 1 1 2 2 2 0 Alpha/beta hydrolase family PTR2 PF00854.21 CCF34315.1 - 4.6e-27 94.9 1.6 6.4e-27 94.4 1.6 1.2 1 0 0 1 1 1 1 POT family Asp PF00026.23 CCF34316.1 - 1.5e-63 215.1 7.5 1.8e-63 214.9 7.5 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCF34316.1 - 2.7e-08 34.3 1.3 0.0021 18.3 0.3 3.0 2 1 1 3 3 3 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 CCF34316.1 - 9.1e-06 26.2 1.5 0.026 15.2 0.4 2.9 2 1 0 2 2 2 2 Aspartyl protease SUKH-4 PF14435.6 CCF34316.1 - 0.12 12.4 0.0 0.19 11.8 0.0 1.3 1 0 0 1 1 1 0 SUKH-4 immunity protein gag-asp_proteas PF13975.6 CCF34316.1 - 0.13 12.8 2.2 1.9 9.1 0.4 2.8 2 1 0 2 2 2 0 gag-polyprotein putative aspartyl protease Methyltransf_23 PF13489.6 CCF34317.1 - 3.3e-22 79.1 0.0 4.9e-22 78.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF34317.1 - 1.1e-08 35.0 0.0 6e-08 32.6 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF34317.1 - 5.5e-08 33.4 0.0 1.5e-07 32.0 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF34317.1 - 7.7e-07 29.8 0.0 8.9e-06 26.4 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF34317.1 - 0.00022 21.8 0.0 0.00047 20.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 CCF34317.1 - 0.0065 16.6 0.0 0.01 16.0 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase MTS PF05175.14 CCF34317.1 - 0.071 12.7 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_4 PF02390.17 CCF34317.1 - 0.083 12.4 0.0 0.083 12.4 0.0 2.3 2 0 0 2 2 2 0 Putative methyltransferase CMAS PF02353.20 CCF34317.1 - 0.17 11.2 0.0 0.46 9.7 0.0 1.6 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase Alpha-amylase PF00128.24 CCF34319.1 - 9.5e-23 81.3 1.3 2.3e-19 70.2 0.6 2.7 2 1 0 2 2 2 2 Alpha amylase, catalytic domain Glyco_transf_5 PF08323.11 CCF34319.1 - 5.5e-17 62.3 0.4 9.1e-17 61.6 0.4 1.3 1 0 0 1 1 1 1 Starch synthase catalytic domain Glycos_transf_1 PF00534.20 CCF34319.1 - 1.1e-06 28.3 0.0 2e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 CCF34319.1 - 0.019 15.0 0.0 0.038 14.0 0.0 1.5 1 0 0 1 1 1 0 Glycosyltransferase Family 4 Fasciclin PF02469.22 CCF34320.1 - 2e-34 118.6 0.0 1.2e-18 67.5 0.0 2.2 2 0 0 2 2 2 2 Fasciclin domain T6_Ig_like PF18002.1 CCF34321.1 - 0.14 12.0 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 T6 antigen Ig like domain Phage_P2_GpE PF06528.12 CCF34321.1 - 0.16 11.6 0.1 0.32 10.6 0.1 1.5 1 0 0 1 1 1 0 Phage P2 GpE Glyco_hydro_18 PF00704.28 CCF34322.1 - 2.8e-49 168.6 0.6 4.7e-49 167.8 0.6 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Chitin_bind_1 PF00187.19 CCF34322.1 - 4.9e-05 23.7 9.0 4.9e-05 23.7 9.0 2.9 2 0 0 2 2 2 1 Chitin recognition protein LysM PF01476.20 CCF34322.1 - 7.4e-05 22.7 0.0 0.36 10.9 0.0 2.7 2 0 0 2 2 2 2 LysM domain Carboxyl_trans PF01039.22 CCF34324.1 - 1.6e-185 617.5 0.0 1.9e-185 617.3 0.0 1.1 1 0 0 1 1 1 1 Carboxyl transferase domain Sugar_tr PF00083.24 CCF34325.1 - 2.6e-104 349.6 17.1 2.9e-104 349.4 17.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF34325.1 - 1.7e-30 106.1 24.7 4.7e-23 81.7 7.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Endonuc-BglII PF09195.11 CCF34325.1 - 0.16 11.8 0.0 0.28 11.0 0.0 1.3 1 0 0 1 1 1 0 Restriction endonuclease BglII Acetyltransf_2 PF00797.17 CCF34326.1 - 1.4e-43 149.5 0.0 1.8e-43 149.1 0.0 1.1 1 0 0 1 1 1 1 N-acetyltransferase ATP_synth_reg PF14960.6 CCF34326.1 - 0.054 13.0 0.0 0.13 11.8 0.0 1.6 1 0 0 1 1 1 0 ATP synthase regulation Inhibitor_I9 PF05922.16 CCF34327.1 - 0.013 16.2 0.0 0.021 15.5 0.0 1.3 1 1 0 1 1 1 0 Peptidase inhibitor I9 Ank_2 PF12796.7 CCF34328.1 - 6.3e-27 94.0 0.3 1.2e-10 41.8 0.0 4.0 1 1 4 5 5 5 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CCF34328.1 - 5.3e-18 63.2 0.4 5.5e-06 26.3 0.0 4.7 6 0 0 6 6 6 3 Ankyrin repeat Ank_4 PF13637.6 CCF34328.1 - 2.5e-17 63.0 2.0 2.3e-08 34.4 0.1 4.2 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 CCF34328.1 - 1.8e-16 60.0 0.4 5.5e-09 36.1 0.0 3.6 2 2 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 CCF34328.1 - 2.5e-15 56.1 0.5 0.00014 22.1 0.0 4.8 5 0 0 5 5 5 3 Ankyrin repeat Pro_isomerase PF00160.21 CCF34329.1 - 4.3e-47 160.3 0.0 4.9e-47 160.1 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD MFS_1 PF07690.16 CCF34330.1 - 2.5e-31 108.9 31.3 2.5e-31 108.9 31.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily tRNA_int_end_N2 PF12928.7 CCF34331.1 - 1.4e-22 79.7 0.1 3e-22 78.6 0.1 1.6 1 0 0 1 1 1 1 tRNA-splicing endonuclease subunit sen54 N-term G6PD_bact PF10786.9 CCF34331.1 - 0.042 13.4 0.6 0.61 9.6 0.1 2.1 2 0 0 2 2 2 0 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) tRNA_int_endo_N PF02778.14 CCF34331.1 - 0.097 12.4 0.0 0.23 11.1 0.0 1.6 1 0 0 1 1 1 0 tRNA intron endonuclease, N-terminal domain His_Phos_2 PF00328.22 CCF34332.1 - 8.5e-17 61.6 0.0 3e-15 56.4 0.0 2.5 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Acyl-CoA_dh_2 PF08028.11 CCF34335.1 - 3.6e-06 27.3 0.1 5.9e-06 26.6 0.1 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 CCF34335.1 - 6e-06 26.4 0.4 2.1e-05 24.6 0.0 1.9 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 CCF34335.1 - 0.0062 17.2 0.0 0.011 16.4 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Bac_luciferase PF00296.20 CCF34336.1 - 1.5e-64 218.4 0.1 1.9e-64 218.1 0.1 1.1 1 0 0 1 1 1 1 Luciferase-like monooxygenase Rap1_C PF11626.8 CCF34336.1 - 0.097 12.8 0.2 8.8 6.5 0.0 2.4 2 0 0 2 2 2 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain Gpr1_Fun34_YaaH PF01184.19 CCF34337.1 - 4.7e-41 140.7 18.4 6.1e-41 140.3 18.4 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family Fungus-induced PF10917.8 CCF34337.1 - 1.2 9.5 5.6 1.3 9.4 0.4 2.6 1 1 1 2 2 2 0 Fungus-induced protein Peptidase_M43 PF05572.13 CCF34339.1 - 9.1e-12 45.1 0.0 2.1e-11 43.9 0.0 1.6 1 0 0 1 1 1 1 Pregnancy-associated plasma protein-A Reprolysin_5 PF13688.6 CCF34339.1 - 0.0003 21.0 1.4 0.0013 18.9 1.4 1.9 1 1 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_2 PF13574.6 CCF34339.1 - 0.0019 18.1 0.2 0.0035 17.2 0.2 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 CCF34339.1 - 0.0079 15.9 0.1 0.012 15.2 0.1 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.6 CCF34339.1 - 0.0084 16.6 0.2 0.015 15.8 0.2 1.5 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.24 CCF34339.1 - 0.051 13.4 0.1 0.11 12.3 0.1 1.5 1 1 0 1 1 1 0 Matrixin Peptidase_M66 PF10462.9 CCF34339.1 - 0.055 12.4 0.9 0.09 11.7 0.9 1.3 1 0 0 1 1 1 0 Peptidase M66 SnoaL PF07366.12 CCF34340.1 - 3.4e-05 23.6 0.1 0.00014 21.7 0.0 2.0 2 0 0 2 2 2 1 SnoaL-like polyketide cyclase SnoaL_2 PF12680.7 CCF34340.1 - 0.0034 18.0 0.1 0.07 13.8 0.0 2.5 1 1 1 2 2 2 1 SnoaL-like domain Lactamase_B_4 PF13691.6 CCF34343.1 - 5.1e-22 77.3 0.1 1.1e-21 76.2 0.1 1.6 1 0 0 1 1 1 1 tRNase Z endonuclease Lactamase_B_2 PF12706.7 CCF34343.1 - 6.6e-17 61.7 0.1 1.3e-16 60.7 0.1 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 CCF34343.1 - 9.8e-05 22.4 0.0 0.00022 21.3 0.0 1.6 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Spem1 PF15670.5 CCF34344.1 - 2.9 7.4 5.9 3.4 7.2 4.4 1.7 2 0 0 2 2 2 0 Spermatid maturation protein 1 Scs3p PF10261.9 CCF34347.1 - 5.3e-76 255.4 8.7 6.6e-76 255.1 8.7 1.1 1 0 0 1 1 1 1 Inositol phospholipid synthesis and fat-storage-inducing TM ATP_transf PF09830.9 CCF34348.1 - 6.8e-22 77.4 0.1 1.5e-21 76.3 0.1 1.6 1 0 0 1 1 1 1 ATP adenylyltransferase Myb_DNA-bind_4 PF13837.6 CCF34349.1 - 0.0059 17.0 0.5 0.012 16.0 0.0 1.8 2 0 0 2 2 2 1 Myb/SANT-like DNA-binding domain Myb_DNA-binding PF00249.31 CCF34349.1 - 0.032 14.4 0.1 0.096 12.9 0.1 1.9 1 0 0 1 1 1 0 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CCF34349.1 - 0.048 13.9 0.0 0.15 12.3 0.0 1.9 1 0 0 1 1 1 0 Myb-like DNA-binding domain ADH_zinc_N PF00107.26 CCF34351.1 - 1.4e-23 83.3 0.4 4.1e-23 81.8 0.3 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCF34351.1 - 1.2e-12 47.7 0.0 1.1e-11 44.6 0.0 2.2 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 CCF34351.1 - 2.8e-10 41.4 0.0 6e-10 40.3 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Sacchrp_dh_NADP PF03435.18 CCF34351.1 - 0.033 14.4 0.1 0.06 13.6 0.1 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain ADH_zinc_N PF00107.26 CCF34352.1 - 4.4e-11 42.9 0.0 1.3e-10 41.3 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCF34352.1 - 0.00012 22.0 0.0 0.00057 19.8 0.0 2.2 2 1 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain DUF2353 PF09789.9 CCF34353.1 - 0.0086 15.5 0.1 0.013 14.9 0.1 1.1 1 0 0 1 1 1 1 Uncharacterized coiled-coil protein (DUF2353) APG6_N PF17675.1 CCF34353.1 - 0.049 14.2 0.3 0.07 13.7 0.3 1.2 1 0 0 1 1 1 0 Apg6 coiled-coil region bZIP_1 PF00170.21 CCF34353.1 - 0.12 12.5 0.4 0.19 11.8 0.4 1.3 1 0 0 1 1 1 0 bZIP transcription factor CorA PF01544.18 CCF34354.1 - 6.4e-27 94.6 5.3 1.6e-22 80.2 3.4 2.8 2 1 0 2 2 2 2 CorA-like Mg2+ transporter protein Dehydrin PF00257.19 CCF34354.1 - 0.009 16.6 3.6 0.016 15.8 3.6 1.3 1 0 0 1 1 1 1 Dehydrin 4HBT PF03061.22 CCF34356.1 - 1.3e-15 57.5 0.1 2e-15 56.9 0.1 1.3 1 0 0 1 1 1 1 Thioesterase superfamily Zn_clus PF00172.18 CCF34358.1 - 1.8e-08 34.3 8.2 3.4e-08 33.5 8.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 CCF34358.1 - 1.1e-05 24.4 0.0 0.00077 18.4 0.0 2.1 2 0 0 2 2 2 2 Fungal specific transcription factor domain GATase PF00117.28 CCF34359.1 - 3e-10 40.2 0.0 5.3e-10 39.4 0.0 1.4 2 0 0 2 2 2 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 CCF34359.1 - 0.0025 17.6 0.0 0.021 14.6 0.0 2.1 1 1 0 1 1 1 1 Peptidase C26 GATase_3 PF07685.14 CCF34359.1 - 0.07 12.7 0.0 0.1 12.2 0.0 1.2 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain MDM10 PF12519.8 CCF34360.1 - 5.1e-14 52.0 0.1 5.1e-14 52.0 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial distribution and morphology protein 10 AA_permease PF00324.21 CCF34361.1 - 3.5e-17 62.2 1.3 3.5e-17 62.2 1.3 1.7 2 0 0 2 2 2 1 Amino acid permease AAA_22 PF13401.6 CCF34362.1 - 1.2e-07 32.0 0.0 2.6e-07 31.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain PNP_UDP_1 PF01048.20 CCF34362.1 - 5.4e-07 29.1 0.0 1.3e-05 24.6 0.0 2.4 3 0 0 3 3 3 1 Phosphorylase superfamily NACHT PF05729.12 CCF34362.1 - 0.00072 19.5 0.0 0.0015 18.5 0.0 1.5 1 1 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 CCF34362.1 - 0.0073 16.7 0.1 0.046 14.1 0.1 2.4 1 1 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.22 CCF34362.1 - 0.013 14.7 0.0 0.15 11.3 0.0 2.2 1 1 0 1 1 1 0 NB-ARC domain IstB_IS21 PF01695.17 CCF34362.1 - 0.1 12.3 0.0 0.24 11.1 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein RRM_1 PF00076.22 CCF34363.1 - 5.3e-12 45.4 0.5 1.1e-07 31.6 0.0 2.8 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Flot PF15975.5 CCF34363.1 - 0.054 13.7 0.4 0.054 13.7 0.4 2.1 2 0 0 2 2 2 0 Flotillin TFIIF_alpha PF05793.12 CCF34363.1 - 0.59 8.7 27.3 0.89 8.1 27.3 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) AAA_13 PF13166.6 CCF34363.1 - 0.89 8.1 10.7 1.2 7.7 10.7 1.1 1 0 0 1 1 1 0 AAA domain Sds3 PF08598.11 CCF34364.1 - 1.7e-13 51.1 7.8 1.7e-13 51.1 7.8 2.9 2 2 1 3 3 3 1 Sds3-like Coiled-coil_56 PF09813.9 CCF34365.1 - 0.033 14.2 0.0 0.034 14.2 0.0 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 56 DUF3453 PF11935.8 CCF34366.1 - 3.2e-37 128.3 0.0 4.1e-37 128.0 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3453) DDHD PF02862.17 CCF34367.1 - 2.6e-65 220.7 2.0 4.7e-64 216.6 0.0 2.6 3 0 0 3 3 3 1 DDHD domain LIDHydrolase PF10230.9 CCF34367.1 - 0.054 13.0 0.0 0.13 11.7 0.0 1.6 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase NPR3 PF03666.13 CCF34367.1 - 9.3 4.9 10.8 3.7 6.2 0.0 2.6 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 zf-RING_2 PF13639.6 CCF34368.1 - 0.0016 18.7 2.4 0.0037 17.6 2.4 1.6 1 0 0 1 1 1 1 Ring finger domain Ank_2 PF12796.7 CCF34368.1 - 0.014 16.0 0.0 0.034 14.7 0.0 1.7 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) zf-C3HC4_4 PF15227.6 CCF34368.1 - 0.11 12.7 3.5 0.29 11.3 3.5 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 CCF34368.1 - 5 7.2 7.5 3.2 7.8 5.1 2.0 1 1 1 2 2 2 0 RING-type zinc-finger DUF3328 PF11807.8 CCF34369.1 - 5.5e-21 75.3 0.7 2.1e-09 37.5 1.1 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF3328) AMP-binding PF00501.28 CCF34370.1 - 7.6e-61 206.0 1.4 8.5e-59 199.2 0.1 2.2 1 1 1 2 2 2 2 AMP-binding enzyme Condensation PF00668.20 CCF34370.1 - 3.3e-19 68.9 0.0 3.7e-17 62.1 0.0 2.9 3 0 0 3 3 3 1 Condensation domain PP-binding PF00550.25 CCF34370.1 - 1.6e-06 28.4 0.0 8e-06 26.1 0.0 2.2 2 0 0 2 2 2 1 Phosphopantetheine attachment site AMP-binding_C PF13193.6 CCF34370.1 - 0.014 16.3 0.0 0.11 13.5 0.0 2.5 2 0 0 2 2 2 0 AMP-binding enzyme C-terminal domain Cyclophil_like2 PF18050.1 CCF34370.1 - 0.071 13.1 0.0 0.19 11.7 0.0 1.6 1 0 0 1 1 1 0 Cyclophilin-like family T4SS PF07996.11 CCF34371.1 - 0.003 18.0 0.5 0.0033 17.9 0.5 1.0 1 0 0 1 1 1 1 Type IV secretion system proteins Amidase PF01425.21 CCF34372.1 - 1.6e-91 307.6 0.0 2.6e-91 306.8 0.0 1.3 1 1 0 1 1 1 1 Amidase MFS_1 PF07690.16 CCF34373.1 - 5.1e-28 98.0 37.3 5.1e-28 98.0 37.3 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily SRR1 PF07985.12 CCF34373.1 - 0.12 12.4 0.2 0.25 11.4 0.2 1.5 1 0 0 1 1 1 0 SRR1 U1snRNP70_N PF12220.8 CCF34374.1 - 2.4e-25 89.0 3.8 4.5e-25 88.1 3.8 1.5 1 0 0 1 1 1 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RRM_1 PF00076.22 CCF34374.1 - 3.4e-17 62.0 0.0 1.5e-16 60.0 0.0 2.0 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CCF34374.1 - 2e-05 24.6 0.0 3.5e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif L51_S25_CI-B8 PF05047.16 CCF34375.1 - 4.6e-17 61.7 0.1 8e-17 60.9 0.1 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain TIM PF00121.18 CCF34376.1 - 1.2e-86 290.1 0.4 1.3e-86 289.9 0.4 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase DUF2431 PF10354.9 CCF34377.1 - 1.5e-60 204.3 0.0 3.1e-60 203.3 0.0 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF2431) ADH_zinc_N PF00107.26 CCF34377.1 - 0.19 11.7 0.0 4.4 7.3 0.0 2.2 2 0 0 2 2 2 0 Zinc-binding dehydrogenase DNA_pol_phi PF04931.13 CCF34377.1 - 0.26 9.4 12.9 0.49 8.4 12.9 1.4 1 0 0 1 1 1 0 DNA polymerase phi NOA36 PF06524.12 CCF34377.1 - 7.4 5.8 13.6 0.75 9.1 8.0 2.0 2 0 0 2 2 2 0 NOA36 protein SRI PF08236.11 CCF34378.1 - 1.3e-21 76.5 6.9 4.2e-21 74.9 6.9 1.9 1 0 0 1 1 1 1 SRI (Set2 Rpb1 interacting) domain SET PF00856.28 CCF34378.1 - 7.9e-18 65.4 0.2 7.9e-18 65.4 0.2 3.3 2 2 0 2 2 2 1 SET domain AWS PF17907.1 CCF34378.1 - 6.1e-12 45.4 6.8 6.1e-12 45.4 6.8 2.3 2 0 0 2 2 2 1 AWS domain Med26 PF08711.11 CCF34378.1 - 9.1e-06 25.6 1.9 1.1e-05 25.3 0.2 2.1 2 0 0 2 2 2 1 TFIIS helical bundle-like domain WW PF00397.26 CCF34378.1 - 0.002 18.2 0.4 0.0052 16.9 0.4 1.8 1 0 0 1 1 1 1 WW domain PRIMA1 PF16101.5 CCF34378.1 - 0.48 10.5 6.1 1.3 9.1 6.1 1.6 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 DUF445 PF04286.12 CCF34378.1 - 2.3 7.9 7.4 6.9 6.4 0.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF445) PARP PF00644.20 CCF34379.1 - 4.6e-08 32.9 0.1 0.00013 21.6 0.0 3.7 1 1 2 3 3 3 2 Poly(ADP-ribose) polymerase catalytic domain RWD PF05773.22 CCF34379.1 - 0.005 17.1 0.0 0.011 16.1 0.0 1.5 1 0 0 1 1 1 1 RWD domain Pectate_lyase PF03211.13 CCF34380.1 - 2.9e-65 219.6 0.6 3.7e-65 219.3 0.6 1.1 1 0 0 1 1 1 1 Pectate lyase HET PF06985.11 CCF34381.1 - 2.4e-12 47.4 3.0 6.7e-09 36.3 0.3 2.3 1 1 0 2 2 2 2 Heterokaryon incompatibility protein (HET) MaoC_dehydratas PF01575.19 CCF34383.1 - 1.7e-33 114.8 0.0 3.4e-33 113.8 0.0 1.5 1 0 0 1 1 1 1 MaoC like domain adh_short PF00106.25 CCF34383.1 - 1.4e-19 70.3 0.7 4.6e-19 68.6 0.0 2.1 3 0 0 3 3 3 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF34383.1 - 9.3e-15 54.8 0.0 1.8e-14 53.8 0.0 1.5 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF34383.1 - 0.0085 16.0 0.0 0.016 15.2 0.0 1.4 1 0 0 1 1 1 1 KR domain SoxE PF06525.11 CCF34383.1 - 0.018 14.6 0.1 2.5 7.6 0.0 2.4 2 0 0 2 2 2 0 Sulfocyanin (SoxE) domain MaoC_dehydrat_N PF13452.6 CCF34383.1 - 0.04 14.1 0.0 4.1 7.6 0.0 2.7 3 0 0 3 3 3 0 N-terminal half of MaoC dehydratase IBR PF01485.21 CCF34384.1 - 1.2e-05 25.5 5.0 1.2e-05 25.5 5.0 4.4 4 1 0 4 4 4 2 IBR domain, a half RING-finger domain adh_short PF00106.25 CCF34385.1 - 6.8e-53 179.0 0.0 9e-53 178.6 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF34385.1 - 4.9e-34 117.9 0.0 6e-34 117.6 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF34385.1 - 1.4e-13 51.2 0.0 1.9e-13 50.7 0.0 1.3 1 0 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.18 CCF34385.1 - 0.003 17.8 0.0 0.0056 16.9 0.0 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Polysacc_synt_2 PF02719.15 CCF34385.1 - 0.0048 16.1 0.2 0.013 14.7 0.1 1.6 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein HNH_2 PF13391.6 CCF34387.1 - 4.1e-11 42.9 0.0 9.9e-11 41.6 0.0 1.7 1 0 0 1 1 1 1 HNH endonuclease DctQ PF04290.12 CCF34390.1 - 2.5 8.0 12.4 0.18 11.7 5.7 2.3 2 1 0 3 3 3 0 Tripartite ATP-independent periplasmic transporters, DctQ component adh_short_C2 PF13561.6 CCF34391.1 - 3.2e-45 154.5 0.0 1.9e-39 135.6 0.0 2.1 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF34391.1 - 4.9e-43 146.9 0.1 6e-43 146.6 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF34391.1 - 1.2e-13 51.4 0.0 1.8e-13 50.8 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF34391.1 - 0.00049 19.6 0.1 0.0024 17.4 0.1 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3HCDH_N PF02737.18 CCF34391.1 - 0.058 13.3 0.1 0.087 12.7 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF1776 PF08643.10 CCF34391.1 - 0.063 12.6 0.0 0.066 12.6 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Ribosomal_L26 PF16906.5 CCF34391.1 - 0.068 13.6 0.0 0.14 12.7 0.0 1.6 2 0 0 2 2 2 0 Ribosomal proteins L26 eukaryotic, L24P archaeal YAcAr PF10686.9 CCF34391.1 - 0.11 12.5 0.1 4.4 7.3 0.1 2.6 2 1 0 2 2 2 0 YspA, cpYpsA-related SLOG family Polysacc_synt_2 PF02719.15 CCF34391.1 - 0.15 11.2 0.0 0.21 10.7 0.0 1.3 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 CCF34391.1 - 0.16 11.3 0.0 0.4 10.0 0.0 1.8 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase DFP PF04127.15 CCF34391.1 - 0.17 11.7 1.2 0.78 9.5 1.2 2.0 1 1 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein DUF382 PF04037.13 CCF34392.1 - 5.1e-59 198.0 1.0 5.1e-59 198.0 1.0 2.2 3 0 0 3 3 3 1 Domain of unknown function (DUF382) PSP PF04046.16 CCF34392.1 - 7.1e-18 64.2 4.5 1.4e-17 63.2 4.5 1.6 1 0 0 1 1 1 1 PSP VEFS-Box PF09733.9 CCF34393.1 - 6.6e-06 26.0 0.0 1.2e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 VEFS-Box of polycomb protein PHD PF00628.29 CCF34393.1 - 0.0013 18.6 4.4 0.0013 18.6 4.4 2.1 3 0 0 3 3 3 1 PHD-finger MTHFR_C PF12225.8 CCF34393.1 - 0.041 13.5 3.1 0.11 12.2 3.1 1.7 1 0 0 1 1 1 0 Methylene-tetrahydrofolate reductase C terminal F-box-like PF12937.7 CCF34394.1 - 0.0075 16.1 0.1 0.02 14.8 0.1 1.7 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.7 CCF34394.1 - 1.5 9.3 10.1 0.25 11.8 0.8 3.7 5 0 0 5 5 5 0 Leucine Rich repeats (2 copies) Arb2 PF09757.9 CCF34396.1 - 3.1e-99 331.3 0.0 4.4e-99 330.8 0.0 1.2 1 0 0 1 1 1 1 Arb2 domain Hist_deacetyl PF00850.19 CCF34396.1 - 6.5e-82 275.4 0.0 1e-81 274.8 0.0 1.3 1 0 0 1 1 1 1 Histone deacetylase domain AMOP PF03782.17 CCF34396.1 - 0.097 12.8 0.0 0.65 10.1 0.0 2.1 2 0 0 2 2 2 0 AMOP domain F-box PF00646.33 CCF34397.1 - 0.0011 18.7 0.0 0.0028 17.5 0.0 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 CCF34397.1 - 0.0029 17.4 0.1 0.081 12.8 0.0 2.6 2 0 0 2 2 2 1 F-box-like F-box_4 PF15966.5 CCF34397.1 - 0.025 14.5 0.0 0.045 13.6 0.0 1.4 1 0 0 1 1 1 0 F-box Ras PF00071.22 CCF34399.1 - 2.7e-63 212.4 0.2 3.2e-63 212.2 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCF34399.1 - 2.8e-35 121.1 0.2 3.9e-35 120.7 0.2 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCF34399.1 - 4.7e-13 48.9 0.1 6e-13 48.6 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 CCF34399.1 - 7.9e-08 32.4 0.1 1.2e-07 31.8 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CCF34399.1 - 0.00035 20.2 0.1 0.0018 17.9 0.0 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 CCF34399.1 - 0.00044 19.7 0.1 0.00065 19.1 0.1 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 CCF34399.1 - 0.00056 19.8 0.9 0.017 15.0 0.1 2.2 1 1 0 2 2 2 1 RsgA GTPase AAA_22 PF13401.6 CCF34399.1 - 0.0031 17.8 0.0 0.019 15.3 0.0 2.0 1 1 0 1 1 1 1 AAA domain SRPRB PF09439.10 CCF34399.1 - 0.015 14.7 0.0 0.026 13.9 0.0 1.3 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_14 PF13173.6 CCF34399.1 - 0.018 15.0 0.1 0.047 13.7 0.1 1.7 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 CCF34399.1 - 0.02 15.3 0.1 0.032 14.6 0.1 1.5 1 1 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 CCF34399.1 - 0.023 15.2 0.1 0.03 14.8 0.1 1.4 1 1 0 1 1 1 0 ABC transporter AAA_24 PF13479.6 CCF34399.1 - 0.03 14.1 0.1 0.064 13.0 0.1 1.7 1 1 0 1 1 1 0 AAA domain TniB PF05621.11 CCF34399.1 - 0.033 13.6 0.0 0.17 11.3 0.0 1.9 2 0 0 2 2 2 0 Bacterial TniB protein AAA_21 PF13304.6 CCF34399.1 - 0.095 12.5 0.5 0.14 11.9 0.5 1.4 1 1 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system SpoIIID PF12116.8 CCF34399.1 - 0.1 12.7 0.1 1.9 8.6 0.0 2.1 2 0 0 2 2 2 0 Stage III sporulation protein D FeoB_N PF02421.18 CCF34399.1 - 0.1 12.1 0.0 0.24 10.9 0.0 1.6 2 0 0 2 2 2 0 Ferrous iron transport protein B MCM PF00493.23 CCF34399.1 - 0.12 11.5 0.0 0.22 10.6 0.0 1.5 1 1 0 1 1 1 0 MCM P-loop domain AAA_7 PF12775.7 CCF34399.1 - 0.12 11.9 0.0 0.21 11.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Chromo PF00385.24 CCF34400.1 - 6.5e-10 38.8 0.8 1.4e-09 37.7 0.8 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain PAZ_siRNAbind PF12212.8 CCF34400.1 - 0.093 12.6 0.0 0.18 11.6 0.0 1.5 1 0 0 1 1 1 0 PAZ domain LRR_1 PF00560.33 CCF34402.1 - 0.099 13.3 0.0 47 5.1 0.0 3.8 3 0 0 3 3 3 0 Leucine Rich Repeat GST_N_2 PF13409.6 CCF34403.1 - 4e-08 33.4 0.1 4.9e-08 33.2 0.1 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 CCF34403.1 - 1.8e-07 31.5 0.1 2.2e-07 31.2 0.1 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 CCF34403.1 - 7e-07 29.5 0.0 8.8e-07 29.2 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Fungal_lectin PF07938.12 CCF34404.1 - 6.4e-10 38.9 3.0 6.3e-07 29.1 0.3 2.5 1 1 1 2 2 2 2 Fungal fucose-specific lectin FtsX PF02687.21 CCF34404.1 - 0.086 13.3 0.1 0.15 12.5 0.1 1.4 1 0 0 1 1 1 0 FtsX-like permease family Peptidase_S10 PF00450.22 CCF34406.1 - 5.6e-92 309.3 0.0 6.4e-92 309.1 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Hydrolase_4 PF12146.8 CCF34406.1 - 0.04 13.2 0.0 2.6 7.3 0.0 2.1 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Peptidase_S10 PF00450.22 CCF34407.1 - 2.1e-76 258.0 0.0 3e-76 257.5 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Hydrolase_4 PF12146.8 CCF34407.1 - 1.6e-05 24.3 0.0 0.17 11.2 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CCF34407.1 - 0.01 15.5 0.0 0.43 10.2 0.0 2.4 2 0 0 2 2 2 0 alpha/beta hydrolase fold Abhydrolase_4 PF08386.10 CCF34407.1 - 0.013 15.6 0.0 1.3 9.2 0.0 2.8 2 0 0 2 2 2 0 TAP-like protein Aminotran_1_2 PF00155.21 CCF34408.1 - 2.1e-51 175.2 0.0 2.5e-51 175.0 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Peptidase_S10 PF00450.22 CCF34409.1 - 1.3e-14 54.5 0.0 1.5e-14 54.3 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase TRI5 PF06330.11 CCF34410.1 - 0.042 12.7 0.0 0.05 12.5 0.0 1.1 1 0 0 1 1 1 0 Trichodiene synthase (TRI5) Methyltransf_24 PF13578.6 CCF34411.1 - 3.1e-18 66.7 0.1 6.2e-18 65.8 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_3 PF01596.17 CCF34411.1 - 0.00028 20.1 0.1 0.0012 18.1 0.1 1.9 1 1 0 1 1 1 1 O-methyltransferase Cons_hypoth95 PF03602.15 CCF34411.1 - 0.008 15.8 0.0 0.016 14.8 0.0 1.5 2 0 0 2 2 2 1 Conserved hypothetical protein 95 AMP-binding PF00501.28 CCF34412.1 - 3.8e-38 131.2 0.0 5.8e-38 130.6 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CCF34412.1 - 0.0005 21.0 1.7 0.00082 20.3 0.5 2.1 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain PP-binding PF00550.25 CCF34412.1 - 0.00072 19.9 0.0 0.0015 18.8 0.0 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site AATase PF07247.12 CCF34412.1 - 0.078 11.5 0.0 4.5 5.7 0.0 2.1 2 0 0 2 2 2 0 Alcohol acetyltransferase MOR2-PAG1_C PF14225.6 CCF34414.1 - 1.8e-93 313.0 1.0 3.6e-93 312.1 0.1 2.0 2 0 0 2 2 2 1 Cell morphogenesis C-terminal MOR2-PAG1_mid PF14228.6 CCF34414.1 - 1.9e-40 138.5 6.5 4.4e-19 67.7 0.1 3.5 2 1 1 3 3 3 3 Cell morphogenesis central region MOR2-PAG1_N PF14222.6 CCF34414.1 - 2.7e-13 49.7 0.0 4.7e-13 49.0 0.0 1.4 1 0 0 1 1 1 1 Cell morphogenesis N-terminal HEAT_2 PF13646.6 CCF34414.1 - 0.077 13.4 1.5 21 5.6 0.1 5.0 6 1 1 7 7 7 0 HEAT repeats HEAT PF02985.22 CCF34414.1 - 0.12 12.6 1.6 4 7.9 0.0 4.0 3 0 0 3 3 3 0 HEAT repeat DIM1 PF02966.16 CCF34415.1 - 1.1e-69 232.3 0.1 1.3e-69 232.1 0.1 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin PF00085.20 CCF34415.1 - 0.029 14.4 0.0 0.039 13.9 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin Thioredoxin_8 PF13905.6 CCF34415.1 - 0.16 12.3 0.7 0.27 11.6 0.7 1.4 1 1 0 1 1 1 0 Thioredoxin-like DUF2677 PF10838.8 CCF34417.1 - 0.00069 19.6 0.1 0.0012 18.8 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2677) Phosducin PF02114.16 CCF34418.1 - 2.6e-09 36.4 0.1 4.5e-08 32.4 0.1 2.2 1 1 0 1 1 1 1 Phosducin FAD_binding_4 PF01565.23 CCF34420.1 - 1.5e-22 79.9 2.1 2.2e-22 79.3 0.5 2.0 1 1 1 2 2 2 1 FAD binding domain BBE PF08031.12 CCF34420.1 - 1.4e-07 31.5 0.0 2.6e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 Berberine and berberine like ABC_membrane PF00664.23 CCF34421.1 - 4.6e-25 88.8 14.1 6.7e-25 88.3 14.1 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 CCF34421.1 - 1.9e-24 86.8 0.0 1.7e-23 83.6 0.0 2.2 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.6 CCF34421.1 - 3.1e-09 37.1 1.1 0.063 13.1 0.0 3.4 2 1 1 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CCF34421.1 - 9.6e-08 31.7 0.7 0.00025 20.6 0.0 2.9 3 0 0 3 3 3 2 RecF/RecN/SMC N terminal domain zf-H2C2 PF09337.10 CCF34421.1 - 0.0057 16.8 0.1 0.014 15.6 0.1 1.7 1 0 0 1 1 1 1 H2C2 zinc finger SbcCD_C PF13558.6 CCF34421.1 - 0.006 16.8 0.3 1.3 9.3 0.1 2.6 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_16 PF13191.6 CCF34421.1 - 0.0093 16.4 0.6 0.0093 16.4 0.6 1.9 2 0 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 CCF34421.1 - 0.011 15.5 0.2 0.025 14.3 0.2 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.6 CCF34421.1 - 0.022 15.0 0.9 0.6 10.4 0.9 2.5 1 1 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 CCF34421.1 - 0.041 13.9 0.3 0.1 12.7 0.3 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase zf-H3C2 PF16721.5 CCF34421.1 - 0.078 13.3 0.0 0.16 12.4 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger like, probable DNA-binding DUF87 PF01935.17 CCF34421.1 - 0.12 12.5 0.3 0.23 11.5 0.3 1.4 1 0 0 1 1 1 0 Helicase HerA, central domain Dynamin_N PF00350.23 CCF34421.1 - 0.14 12.2 0.2 0.25 11.4 0.2 1.4 1 0 0 1 1 1 0 Dynamin family YebO PF13974.6 CCF34421.1 - 0.4 10.8 2.2 0.67 10.1 0.0 2.5 3 0 0 3 3 3 0 YebO-like protein DUF3325 PF11804.8 CCF34422.1 - 0.09 12.9 0.7 0.35 11.0 0.7 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3325) CCDC71L PF15374.6 CCF34422.1 - 0.22 10.7 3.5 0.34 10.1 3.5 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 71L MFS_1 PF07690.16 CCF34423.1 - 1.8e-23 83.1 23.3 2.1e-23 82.8 23.3 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF2530 PF10745.9 CCF34423.1 - 0.3 11.3 0.1 0.3 11.3 0.1 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2530) Rhomboid PF01694.22 CCF34423.1 - 3.1 7.8 10.1 0.089 12.8 1.7 2.5 2 1 0 2 2 2 0 Rhomboid family DUF2306 PF10067.9 CCF34423.1 - 3.2 8.0 10.5 0.19 11.9 1.3 3.0 3 0 0 3 3 3 0 Predicted membrane protein (DUF2306) WD40 PF00400.32 CCF34425.1 - 1.4e-11 44.8 3.6 0.0024 18.7 0.0 5.3 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF34425.1 - 5.4e-09 36.2 0.0 0.39 11.0 0.0 4.5 1 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CCF34425.1 - 0.031 12.9 0.0 0.05 12.2 0.0 1.3 1 0 0 1 1 1 0 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 CCF34425.1 - 0.082 11.8 0.0 9.7 5.0 0.0 2.2 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Fungal_trans PF04082.18 CCF34426.1 - 5.4e-21 74.8 0.1 1.2e-20 73.7 0.0 1.5 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF34426.1 - 5e-09 36.1 8.4 1e-08 35.1 8.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AMP-binding PF00501.28 CCF34428.1 - 2.2e-90 303.3 0.0 2.6e-90 303.1 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CCF34428.1 - 5.4e-15 56.1 0.1 7.5e-14 52.5 0.0 2.7 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain HMGL-like PF00682.19 CCF34429.1 - 1.8e-40 139.2 0.0 3.4e-40 138.3 0.0 1.5 1 1 0 1 1 1 1 HMGL-like ECH_1 PF00378.20 CCF34429.1 - 4e-36 124.6 0.0 6.6e-36 123.9 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CCF34429.1 - 6.6e-25 88.3 0.0 9.5e-25 87.8 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Ad_Cy_reg PF16701.5 CCF34429.1 - 0.077 12.7 0.1 15 5.3 0.0 2.8 2 0 0 2 2 2 0 Adenylate cyclase regulatory domain Neur PF00064.18 CCF34429.1 - 0.13 11.1 0.0 0.2 10.4 0.0 1.2 1 0 0 1 1 1 0 Neuraminidase ABC_membrane PF00664.23 CCF34430.1 - 3.2e-82 276.3 31.4 7.5e-45 153.7 10.6 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 CCF34430.1 - 1.7e-64 216.4 0.0 3.6e-32 111.8 0.0 3.4 2 1 1 3 3 3 3 ABC transporter SMC_N PF02463.19 CCF34430.1 - 1.1e-13 51.2 7.4 6.5e-05 22.5 1.6 4.2 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 CCF34430.1 - 1.9e-07 31.4 0.5 0.021 15.1 0.1 3.3 3 1 0 3 3 3 2 AAA domain AAA_29 PF13555.6 CCF34430.1 - 9e-07 28.5 2.7 0.0008 19.1 0.5 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 CCF34430.1 - 9.2e-07 29.4 0.9 0.068 13.6 0.1 3.6 3 1 0 3 3 3 2 AAA ATPase domain RsgA_GTPase PF03193.16 CCF34430.1 - 1.1e-05 25.4 0.0 0.23 11.4 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase ABC_ATPase PF09818.9 CCF34430.1 - 2.6e-05 23.2 0.6 0.22 10.3 0.0 3.0 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA_21 PF13304.6 CCF34430.1 - 4.3e-05 23.5 0.1 0.13 12.1 0.0 3.3 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_18 PF13238.6 CCF34430.1 - 4.8e-05 23.9 0.4 0.19 12.3 0.3 2.5 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.6 CCF34430.1 - 7.7e-05 22.5 0.2 1 9.0 0.0 3.6 3 1 0 3 3 3 2 AAA domain AAA_7 PF12775.7 CCF34430.1 - 8.1e-05 22.2 0.0 0.42 10.1 0.0 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA PF00004.29 CCF34430.1 - 0.00011 22.6 3.1 0.77 10.2 0.2 4.5 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_15 PF13175.6 CCF34430.1 - 0.00026 20.8 4.9 0.029 14.1 0.0 2.4 2 1 0 2 2 2 1 AAA ATPase domain DUF3987 PF13148.6 CCF34430.1 - 0.00048 19.3 0.2 0.0011 18.1 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3987) AAA_25 PF13481.6 CCF34430.1 - 0.00057 19.5 0.2 0.7 9.4 0.0 3.3 3 0 0 3 3 3 1 AAA domain Rad17 PF03215.15 CCF34430.1 - 0.0011 18.9 0.3 1 9.2 0.0 2.5 2 0 0 2 2 2 2 Rad17 P-loop domain ATP-synt_ab PF00006.25 CCF34430.1 - 0.0019 17.9 0.5 2.2 7.9 0.0 3.0 3 0 0 3 3 2 2 ATP synthase alpha/beta family, nucleotide-binding domain AAA_5 PF07728.14 CCF34430.1 - 0.0023 17.9 0.1 2.4 8.1 0.0 3.3 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 CCF34430.1 - 0.0085 15.8 0.1 4.2 7.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain SbcCD_C PF13558.6 CCF34430.1 - 0.0096 16.1 1.4 3.4 8.0 0.3 3.6 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit ATP_bind_1 PF03029.17 CCF34430.1 - 0.026 14.3 0.0 0.54 10.0 0.0 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_33 PF13671.6 CCF34430.1 - 0.03 14.5 0.1 2.5 8.3 0.1 2.7 2 0 0 2 2 2 0 AAA domain Dala_Dala_lig_N PF01820.21 CCF34430.1 - 0.039 14.4 0.4 9.2 6.8 0.0 3.1 3 0 0 3 3 3 0 D-ala D-ala ligase N-terminus PRK PF00485.18 CCF34430.1 - 0.046 13.5 0.1 11 5.7 0.0 2.4 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family RNA_helicase PF00910.22 CCF34430.1 - 0.047 14.1 0.2 10 6.5 0.0 3.0 3 0 0 3 3 2 0 RNA helicase IstB_IS21 PF01695.17 CCF34430.1 - 0.051 13.3 0.5 5.3 6.7 0.0 2.9 3 0 0 3 3 2 0 IstB-like ATP binding protein Roc PF08477.13 CCF34430.1 - 0.052 13.8 1.6 4.6 7.5 0.7 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_28 PF13521.6 CCF34430.1 - 0.068 13.4 0.2 12 6.1 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 CCF34430.1 - 0.07 13.6 13.6 0.24 11.9 0.4 3.3 3 0 0 3 3 2 0 AAA domain APS_kinase PF01583.20 CCF34430.1 - 0.073 13.0 0.1 11 5.8 0.0 2.8 2 0 0 2 2 2 0 Adenylylsulphate kinase AAA_14 PF13173.6 CCF34430.1 - 0.17 11.9 0.9 33 4.5 0.3 3.3 3 0 0 3 3 3 0 AAA domain hNIFK_binding PF12196.8 CCF34430.1 - 0.37 10.3 1.2 0.87 9.1 1.2 1.6 1 0 0 1 1 1 0 FHA Ki67 binding domain of hNIFK Apc15p PF05841.11 CCF34430.1 - 4.4 8.1 7.1 0.19 12.5 0.9 1.8 2 0 0 2 2 1 0 Apc15p protein Glyco_hydro_18 PF00704.28 CCF34432.1 - 6.2e-40 137.8 0.1 7.5e-40 137.6 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Glyco_hydro_85 PF03644.13 CCF34432.1 - 0.0033 16.9 0.0 0.004 16.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 85 CoaE PF01121.20 CCF34433.1 - 0.13 11.9 0.0 0.23 11.1 0.0 1.2 1 0 0 1 1 1 0 Dephospho-CoA kinase MFAP1 PF06991.11 CCF34436.1 - 2.6e-68 230.1 28.1 2.6e-68 230.1 28.1 2.6 2 1 0 2 2 2 1 Microfibril-associated/Pre-mRNA processing Zn_clus PF00172.18 CCF34439.1 - 0.00016 21.7 13.2 0.00029 20.9 13.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 CCF34441.1 - 2.2e-32 112.4 43.7 7e-32 110.7 43.7 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 CCF34441.1 - 1.3e-07 30.4 9.6 2.1e-07 29.8 9.6 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.20 CCF34441.1 - 0.0038 15.6 1.5 0.0038 15.6 1.5 2.3 2 0 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family p450 PF00067.22 CCF34442.1 - 9.1e-57 192.8 0.0 1.1e-56 192.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF4051 PF13260.6 CCF34442.1 - 0.043 13.5 0.6 0.099 12.4 0.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4051) PP-binding PF00550.25 CCF34443.1 - 0.064 13.6 0.0 0.075 13.4 0.0 1.1 1 0 0 1 1 1 0 Phosphopantetheine attachment site p450 PF00067.22 CCF34444.1 - 3.2e-47 161.3 0.0 4.1e-34 118.1 0.0 2.5 2 1 0 2 2 2 2 Cytochrome P450 RSN1_7TM PF02714.15 CCF34445.1 - 1e-83 280.9 16.2 1.5e-83 280.3 16.2 1.3 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_ext PF12621.8 CCF34445.1 - 2e-30 104.8 0.1 1.7e-28 98.6 0.0 2.4 2 0 0 2 2 2 1 Extracellular tail, of 10TM putative phosphate transporter PHM7_cyt PF14703.6 CCF34445.1 - 1.5e-24 87.2 0.0 2.2e-24 86.6 0.0 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter RRM_1 PF00076.22 CCF34445.1 - 0.0064 16.3 0.0 0.015 15.1 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transferase PF02458.15 CCF34446.1 - 1.1e-10 40.8 0.0 9.3e-10 37.7 0.0 2.3 2 1 0 2 2 2 1 Transferase family TauD PF02668.16 CCF34447.1 - 1.4e-51 175.9 0.3 1.6e-51 175.7 0.3 1.0 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Fungal_trans PF04082.18 CCF34449.1 - 1.1e-36 126.3 0.0 1.6e-36 125.8 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain T6PP_N PF18572.1 CCF34452.1 - 0.023 14.5 0.5 0.21 11.4 0.0 2.0 2 0 0 2 2 2 0 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain GFO_IDH_MocA PF01408.22 CCF34453.1 - 3.9e-21 76.1 0.1 1.4e-20 74.3 0.0 1.9 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 CCF34453.1 - 1.1e-07 31.9 0.0 2.1e-07 31.0 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain AAA_33 PF13671.6 CCF34453.1 - 0.00031 20.9 0.0 0.00064 19.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain NAD_binding_3 PF03447.16 CCF34453.1 - 0.00034 21.2 0.0 0.00077 20.1 0.0 1.6 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain Fungal_trans_2 PF11951.8 CCF34454.1 - 2.1e-05 23.5 0.0 3e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain GFA PF04828.14 CCF34455.1 - 4.2e-23 81.5 0.4 5.6e-23 81.1 0.4 1.2 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme CTP_transf_like PF01467.26 CCF34456.1 - 2.5e-22 79.6 0.0 3.1e-22 79.3 0.0 1.1 1 0 0 1 1 1 1 Cytidylyltransferase-like PNK3P PF08645.11 CCF34458.1 - 3.4e-58 195.9 0.1 4.9e-58 195.4 0.1 1.2 1 0 0 1 1 1 1 Polynucleotide kinase 3 phosphatase AAA_33 PF13671.6 CCF34458.1 - 1.1e-26 93.8 0.0 4.4e-24 85.3 0.0 2.5 1 1 0 1 1 1 1 AAA domain Rad17 PF03215.15 CCF34458.1 - 0.013 15.4 0.1 0.037 13.9 0.0 1.7 2 0 0 2 2 2 0 Rad17 P-loop domain Med18 PF09637.10 CCF34459.1 - 2.5e-29 102.9 0.0 2.9e-29 102.7 0.0 1.0 1 0 0 1 1 1 1 Med18 protein FRP PF18032.1 CCF34459.1 - 0.1 13.2 3.7 2.6 8.7 0.1 3.0 3 0 0 3 3 3 0 Photoprotection regulator fluorescence recovery protein Acetyltransf_1 PF00583.25 CCF34460.1 - 3.2e-08 33.8 0.0 5.5e-08 33.1 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CCF34460.1 - 1.5e-06 28.5 0.0 2.8e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CCF34460.1 - 0.00026 20.9 0.0 0.00047 20.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 CCF34460.1 - 0.0003 20.8 0.0 0.0099 16.0 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CCF34460.1 - 0.0023 17.9 0.0 0.0071 16.3 0.0 1.8 1 1 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 CCF34460.1 - 0.092 12.9 0.0 0.19 11.9 0.0 1.5 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Zn_clus PF00172.18 CCF34461.1 - 1e-05 25.5 15.4 2.3e-05 24.4 15.4 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CCF34461.1 - 3.7e-05 22.9 0.1 6.2e-05 22.2 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain peroxidase PF00141.23 CCF34464.1 - 1.2e-27 97.1 0.0 1.7e-27 96.6 0.0 1.2 1 0 0 1 1 1 1 Peroxidase ANAPC4_WD40 PF12894.7 CCF34465.1 - 0.17 12.2 0.0 12 6.3 0.0 2.8 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CCF34465.1 - 2.9 8.9 6.2 20 6.2 0.3 4.2 5 0 0 5 5 5 0 WD domain, G-beta repeat DUF1687 PF07955.11 CCF34466.1 - 2.2e-34 118.7 0.4 2.8e-34 118.3 0.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1687) Ribosomal_L14e PF01929.17 CCF34469.1 - 3e-29 101.3 2.2 4e-29 100.9 2.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L14 KOW PF00467.29 CCF34469.1 - 0.0011 18.8 0.1 0.0066 16.4 0.0 2.3 2 0 0 2 2 2 1 KOW motif NAC PF01849.18 CCF34470.1 - 5.6e-23 80.7 0.2 2.1e-22 78.9 0.0 2.0 2 0 0 2 2 2 1 NAC domain PGA2 PF07543.12 CCF34470.1 - 1.8 8.5 12.1 7.3 6.6 0.7 2.1 2 0 0 2 2 2 0 Protein trafficking PGA2 Cwf_Cwc_15 PF04889.12 CCF34470.1 - 2.9 7.6 14.2 4.6 6.9 1.0 2.1 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein DUF2417 PF10329.9 CCF34473.1 - 7.8e-72 241.5 9.1 9.4e-72 241.2 9.1 1.0 1 0 0 1 1 1 1 Region of unknown function (DUF2417) DUF2070 PF09843.9 CCF34473.1 - 0.0083 14.5 11.1 0.011 14.1 11.1 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2070) DUF4267 PF14087.6 CCF34473.1 - 0.48 10.5 4.5 0.23 11.5 1.9 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4267) Pkinase PF00069.25 CCF34475.1 - 4.4e-38 131.2 0.0 5.1e-38 131.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF34475.1 - 1e-21 77.4 0.0 1.2e-21 77.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF34475.1 - 0.00074 18.9 0.0 0.001 18.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 CCF34475.1 - 0.00077 18.9 0.0 0.0013 18.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 CCF34475.1 - 0.0057 15.5 0.0 0.0074 15.1 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 CCF34475.1 - 0.014 15.4 0.4 0.053 13.4 0.0 1.9 2 0 0 2 2 2 0 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 CCF34475.1 - 0.27 10.2 0.0 2.3 7.1 0.0 1.9 1 1 1 2 2 2 0 Poxvirus serine/threonine protein kinase p450 PF00067.22 CCF34476.1 - 1e-60 205.8 0.0 1.2e-60 205.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 ALO PF04030.14 CCF34477.1 - 0.034 14.0 0.0 0.065 13.0 0.0 1.5 1 1 0 1 1 1 0 D-arabinono-1,4-lactone oxidase RabGAP-TBC PF00566.18 CCF34478.1 - 2.3e-47 161.5 0.0 3.6e-47 160.8 0.0 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain EF-hand_6 PF13405.6 CCF34478.1 - 4.9e-07 29.2 0.4 0.014 15.3 0.3 3.6 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 CCF34478.1 - 0.00029 20.2 1.0 0.074 12.6 0.6 3.6 3 0 0 3 3 3 1 EF hand EF-hand_7 PF13499.6 CCF34478.1 - 0.0019 18.6 1.8 0.0038 17.6 0.1 2.5 2 0 0 2 2 2 1 EF-hand domain pair GRAM PF02893.20 CCF34478.1 - 0.017 15.0 0.0 0.038 13.9 0.0 1.6 1 0 0 1 1 1 0 GRAM domain EF-hand_5 PF13202.6 CCF34478.1 - 0.045 13.3 0.2 0.14 11.7 0.2 1.9 1 0 0 1 1 1 0 EF hand Lactamase_B_3 PF13483.6 CCF34479.1 - 0.034 14.1 0.0 0.062 13.2 0.0 1.5 2 0 0 2 2 2 0 Beta-lactamase superfamily domain RIIa PF02197.17 CCF34480.1 - 0.22 11.2 6.9 11 5.8 0.6 3.7 4 0 0 4 4 4 0 Regulatory subunit of type II PKA R-subunit Aa_trans PF01490.18 CCF34481.1 - 2.5e-37 128.5 33.9 2.9e-37 128.4 33.9 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Herpes_teg_N PF04843.12 CCF34481.1 - 0.038 13.7 0.0 0.16 11.7 0.0 1.9 2 0 0 2 2 2 0 Herpesvirus tegument protein, N-terminal conserved region Ank_4 PF13637.6 CCF34483.1 - 3e-07 30.9 0.0 4.4e-06 27.1 0.0 2.8 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 CCF34483.1 - 7.4e-07 29.7 0.0 1.7e-06 28.5 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 CCF34483.1 - 4.6e-06 26.8 0.1 0.023 15.1 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 CCF34483.1 - 5.1e-05 23.5 0.1 0.017 15.5 0.1 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCF34483.1 - 0.00022 21.4 0.0 2.4 9.0 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat NACHT PF05729.12 CCF34483.1 - 0.0031 17.5 0.2 0.014 15.3 0.1 2.0 2 0 0 2 2 2 1 NACHT domain KAP_NTPase PF07693.14 CCF34483.1 - 0.0072 15.6 0.0 0.011 15.0 0.0 1.3 1 0 0 1 1 1 1 KAP family P-loop domain Keratin_2_head PF16208.5 CCF34484.1 - 1.6 8.9 12.8 2.1 8.5 12.8 1.3 1 1 0 1 1 1 0 Keratin type II head ABC_tran PF00005.27 CCF34485.1 - 4e-50 169.9 0.0 5.1e-30 104.8 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 CCF34485.1 - 2e-32 112.9 16.0 1.5e-23 83.8 5.3 3.0 3 0 0 3 3 3 2 ABC transporter transmembrane region SMC_N PF02463.19 CCF34485.1 - 2.5e-10 40.2 0.2 0.0003 20.3 0.0 4.3 3 1 1 4 4 4 1 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 CCF34485.1 - 0.00084 19.4 0.0 0.036 14.2 0.0 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CCF34485.1 - 0.0016 18.3 0.2 1.8 8.5 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 CCF34485.1 - 0.0017 18.8 0.3 0.44 10.9 0.1 2.8 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 CCF34485.1 - 0.0026 18.0 0.5 4.2 7.6 0.0 3.3 2 1 0 2 2 2 1 AAA domain AAA_29 PF13555.6 CCF34485.1 - 0.0043 16.8 0.7 2.5 7.9 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 CCF34485.1 - 0.0076 16.8 1.4 0.95 9.9 0.1 3.0 3 0 0 3 3 3 1 AAA domain T2SSE PF00437.20 CCF34485.1 - 0.011 14.8 0.1 2.1 7.3 0.1 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_25 PF13481.6 CCF34485.1 - 0.012 15.2 0.0 1.3 8.6 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_21 PF13304.6 CCF34485.1 - 0.024 14.5 0.3 9.1 6.0 0.0 3.7 3 1 1 4 4 4 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_30 PF13604.6 CCF34485.1 - 0.029 14.1 0.3 6 6.5 0.1 3.1 3 0 0 3 3 3 0 AAA domain IstB_IS21 PF01695.17 CCF34485.1 - 0.039 13.7 0.8 1.3 8.7 0.0 2.7 3 0 0 3 3 3 0 IstB-like ATP binding protein DUF4834 PF16118.5 CCF34485.1 - 0.073 14.0 0.1 0.33 11.9 0.0 2.1 2 0 0 2 2 1 0 Domain of unknown function (DUF4834) FAM176 PF14851.6 CCF34485.1 - 0.11 12.2 2.1 0.29 10.8 0.0 2.6 3 0 0 3 3 3 0 FAM176 family DUF2075 PF09848.9 CCF34485.1 - 0.11 11.7 0.1 1.7 7.8 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_7 PF12775.7 CCF34485.1 - 0.15 11.5 0.2 14 5.2 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region CbiA PF01656.23 CCF34485.1 - 0.33 11.0 0.9 31 4.6 0.7 2.7 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain DUF87 PF01935.17 CCF34485.1 - 3.4 7.7 9.3 1.1 9.3 0.2 2.8 3 0 0 3 3 3 0 Helicase HerA, central domain MFS_1 PF07690.16 CCF34486.1 - 7.5e-10 38.3 29.6 3.9e-08 32.6 11.3 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3301 PF11743.8 CCF34486.1 - 0.048 13.3 0.1 0.11 12.2 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3301) HIG_1_N PF04588.13 CCF34486.1 - 0.18 12.1 6.0 0.53 10.6 0.4 2.5 2 0 0 2 2 2 0 Hypoxia induced protein conserved region GMC_oxred_N PF00732.19 CCF34487.1 - 9.3e-59 199.2 0.0 1.2e-58 198.9 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCF34487.1 - 2.8e-32 112.2 0.0 5.6e-32 111.2 0.0 1.5 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 CCF34487.1 - 5.4e-07 29.0 0.0 0.027 13.6 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 CCF34487.1 - 0.0005 20.2 0.1 0.0014 18.8 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CCF34487.1 - 0.0012 18.6 0.7 0.0083 15.8 0.1 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 CCF34487.1 - 0.01 15.1 0.0 0.021 14.0 0.0 1.4 1 0 0 1 1 1 0 Thi4 family Lycopene_cycl PF05834.12 CCF34487.1 - 0.014 14.4 0.0 0.032 13.3 0.0 1.5 2 0 0 2 2 2 0 Lycopene cyclase protein Pyr_redox_2 PF07992.14 CCF34487.1 - 0.023 13.9 0.0 0.26 10.5 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CCF34487.1 - 0.087 12.8 0.0 0.2 11.6 0.0 1.6 1 0 0 1 1 1 0 FAD-NAD(P)-binding DAGAT PF03982.13 CCF34487.1 - 0.2 10.5 0.0 0.32 9.9 0.0 1.2 1 0 0 1 1 1 0 Diacylglycerol acyltransferase NmrA PF05368.13 CCF34488.1 - 7.8e-24 84.5 0.1 1.1e-23 84.1 0.1 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CCF34488.1 - 8.6e-18 64.9 0.0 3.3e-17 63.0 0.0 1.9 1 1 0 1 1 1 1 NAD(P)H-binding DapB_N PF01113.20 CCF34488.1 - 0.0083 16.2 0.0 0.021 14.9 0.0 1.8 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus KR PF08659.10 CCF34488.1 - 0.15 11.9 0.0 0.26 11.2 0.0 1.4 1 0 0 1 1 1 0 KR domain NmrA PF05368.13 CCF34489.1 - 0.0012 18.4 0.0 0.0013 18.4 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family Peptidase_S8 PF00082.22 CCF34490.1 - 7.4e-27 94.4 0.0 1.3e-26 93.5 0.0 1.3 1 0 0 1 1 1 1 Subtilase family TPR_12 PF13424.6 CCF34490.1 - 0.00012 22.2 0.0 0.00039 20.7 0.0 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 CCF34490.1 - 0.00023 20.8 0.0 0.0024 17.6 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 CCF34490.1 - 0.0024 17.9 0.5 0.023 14.8 0.1 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 CCF34490.1 - 0.042 14.1 0.0 0.27 11.6 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat Nterm_IS4 PF13006.7 CCF34490.1 - 0.36 11.0 3.2 2.6 8.3 0.0 2.6 2 0 0 2 2 2 0 Insertion element 4 transposase N-terminal DUF5401 PF17380.2 CCF34490.1 - 7.6 4.5 67.5 12 3.8 67.5 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5401) GMC_oxred_N PF00732.19 CCF34491.1 - 1.9e-50 171.9 0.0 2.2e-50 171.7 0.0 1.0 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 CCF34491.1 - 4.4e-08 32.6 0.8 0.00048 19.3 0.1 2.2 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 CCF34491.1 - 0.00012 21.8 2.7 0.0012 18.5 2.7 2.2 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CCF34491.1 - 0.0011 19.1 2.2 0.0013 18.9 0.9 1.8 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CCF34491.1 - 0.0055 16.0 0.2 0.047 12.9 0.1 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCF34491.1 - 0.012 14.9 0.0 0.19 10.9 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CCF34491.1 - 0.015 14.5 0.4 0.037 13.3 0.1 1.7 2 0 0 2 2 2 0 Thi4 family HI0933_like PF03486.14 CCF34491.1 - 0.062 12.0 0.2 0.093 11.4 0.2 1.2 1 0 0 1 1 1 0 HI0933-like protein FAD_binding_3 PF01494.19 CCF34491.1 - 0.13 11.5 0.2 0.24 10.6 0.2 1.4 1 0 0 1 1 1 0 FAD binding domain Pyr_redox PF00070.27 CCF34491.1 - 0.18 12.4 0.3 1.7 9.2 0.4 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase adh_short PF00106.25 CCF34492.1 - 6.3e-32 110.6 0.2 1.5e-31 109.3 0.2 1.5 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF34492.1 - 2.8e-22 79.4 0.0 4.9e-22 78.6 0.0 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF34492.1 - 1.5e-09 38.1 0.0 2.1e-09 37.6 0.0 1.1 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 CCF34492.1 - 0.083 12.8 0.2 0.17 11.8 0.2 1.5 1 1 0 1 1 1 0 NAD(P)H-binding DUF1776 PF08643.10 CCF34492.1 - 0.14 11.5 0.0 0.21 10.9 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Trimer_CC PF08954.11 CCF34492.1 - 0.21 11.2 0.0 0.41 10.2 0.0 1.5 1 0 0 1 1 1 0 Trimerisation motif ketoacyl-synt PF00109.26 CCF34493.1 - 2.9e-58 197.4 0.2 3.7e-58 197.1 0.2 1.1 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 CCF34493.1 - 1e-19 70.7 0.0 3.4e-19 69.0 0.0 1.9 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.23 CCF34493.1 - 0.015 14.7 0.3 0.026 13.9 0.3 1.3 1 0 0 1 1 1 0 Thiolase, N-terminal domain NAD_binding_2 PF03446.15 CCF34494.1 - 7e-19 68.5 0.0 7.9e-19 68.4 0.0 1.1 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.20 CCF34494.1 - 0.00095 19.2 0.0 0.0012 18.9 0.0 1.2 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 CCF34494.1 - 0.011 15.2 0.1 0.019 14.3 0.0 1.5 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FUSC PF04632.12 CCF34495.1 - 0.017 13.7 0.0 0.025 13.1 0.0 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family PP2C PF00481.21 CCF34496.1 - 1.3e-84 283.9 0.0 1.3e-84 283.9 0.0 1.5 2 0 0 2 2 2 1 Protein phosphatase 2C Sugar_tr PF00083.24 CCF34497.1 - 4.1e-101 339.1 17.7 4.5e-101 338.9 17.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF34497.1 - 6.9e-23 81.1 46.1 5.4e-16 58.5 13.2 2.0 1 1 0 2 2 2 2 Major Facilitator Superfamily DUF4410 PF14366.6 CCF34497.1 - 0.12 12.2 0.1 1.4 8.9 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4410) DUF3980 PF13140.6 CCF34497.1 - 0.16 12.5 5.2 38 4.8 0.2 4.0 2 1 1 3 3 3 0 Domain of unknown function (DUF3980) tRNA-synt_2 PF00152.20 CCF34498.1 - 1.3e-25 90.2 0.0 1.7e-25 89.7 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) Collagen_mid PF15984.5 CCF34499.1 - 0.0025 17.6 13.9 0.0033 17.2 13.9 1.2 1 0 0 1 1 1 1 Bacterial collagen, middle region VPS13_C PF16909.5 CCF34499.1 - 0.62 9.8 5.2 0.34 10.7 3.3 1.6 1 1 0 1 1 1 0 Vacuolar-sorting-associated 13 protein C-terminal p450 PF00067.22 CCF34501.1 - 7.9e-76 255.7 0.0 9.9e-76 255.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 BCDHK_Adom3 PF10436.9 CCF34504.1 - 1.8e-47 161.2 0.1 3.2e-47 160.4 0.1 1.4 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 CCF34504.1 - 1.2e-07 32.2 0.0 4.2e-07 30.5 0.0 1.8 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 CCF34504.1 - 0.0025 17.6 0.0 0.0049 16.7 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Septin PF00735.18 CCF34505.1 - 6.9e-114 379.9 0.2 1e-113 379.3 0.2 1.3 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 CCF34505.1 - 2.6e-07 30.7 0.0 5.4e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CCF34505.1 - 7.7e-06 25.9 1.6 3.2e-05 23.9 0.0 2.6 3 0 0 3 3 3 1 RsgA GTPase GTP_EFTU PF00009.27 CCF34505.1 - 1.2e-05 24.9 4.2 7.7e-05 22.3 0.1 2.8 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 CCF34505.1 - 0.002 18.4 0.8 0.0056 16.9 0.1 2.1 2 1 0 2 2 2 1 AAA domain Pox_A32 PF04665.12 CCF34505.1 - 0.0025 17.3 0.1 0.0052 16.3 0.1 1.5 1 0 0 1 1 1 1 Poxvirus A32 protein Roc PF08477.13 CCF34505.1 - 0.0035 17.5 0.1 0.0078 16.4 0.1 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AIG1 PF04548.16 CCF34505.1 - 0.0071 15.7 0.0 0.015 14.6 0.0 1.5 1 0 0 1 1 1 1 AIG1 family IIGP PF05049.13 CCF34505.1 - 0.0089 15.1 0.0 0.016 14.3 0.0 1.4 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) Casc1_N PF15927.5 CCF34505.1 - 0.012 15.3 11.4 0.03 14.0 11.4 1.6 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 N-terminus AAA_24 PF13479.6 CCF34505.1 - 0.013 15.3 0.0 0.027 14.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain Ras PF00071.22 CCF34505.1 - 0.02 14.5 0.5 0.062 12.9 0.5 1.8 1 1 0 1 1 1 0 Ras family KAP_NTPase PF07693.14 CCF34505.1 - 0.028 13.7 0.0 0.04 13.1 0.0 1.6 1 1 0 1 1 1 0 KAP family P-loop domain AAA_16 PF13191.6 CCF34505.1 - 0.036 14.5 1.1 0.095 13.1 0.0 2.2 2 1 0 2 2 2 0 AAA ATPase domain T2SSE PF00437.20 CCF34505.1 - 0.045 12.8 0.4 0.18 10.8 0.0 2.0 2 0 0 2 2 2 0 Type II/IV secretion system protein NACHT PF05729.12 CCF34505.1 - 0.048 13.6 0.0 0.099 12.6 0.0 1.5 1 0 0 1 1 1 0 NACHT domain ABC_tran PF00005.27 CCF34505.1 - 0.053 14.0 0.3 0.2 12.2 0.0 2.0 2 0 0 2 2 2 0 ABC transporter FOXP-CC PF16159.5 CCF34505.1 - 0.066 13.8 1.2 0.066 13.8 1.2 2.5 2 1 1 3 3 2 0 FOXP coiled-coil domain AAA_25 PF13481.6 CCF34505.1 - 0.078 12.5 0.2 0.3 10.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 CCF34505.1 - 0.081 12.6 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain PduV-EutP PF10662.9 CCF34505.1 - 0.13 12.0 0.4 8.3 6.2 0.1 2.7 1 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation RNA_helicase PF00910.22 CCF34505.1 - 0.14 12.5 0.0 0.43 11.0 0.0 1.9 2 0 0 2 2 1 0 RNA helicase Dynamin_N PF00350.23 CCF34505.1 - 0.54 10.3 7.3 4.2 7.4 0.1 3.1 2 1 1 3 3 3 0 Dynamin family FUSC PF04632.12 CCF34505.1 - 3.2 6.2 4.6 4.4 5.7 4.6 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family AAA_11 PF13086.6 CCF34505.1 - 3.8 7.2 7.5 23 4.7 0.1 2.2 2 0 0 2 2 2 0 AAA domain Myc-LZ PF02344.15 CCF34505.1 - 4.3 7.5 9.1 5.2 7.3 3.1 3.2 2 1 0 2 2 2 0 Myc leucine zipper domain WD40 PF00400.32 CCF34506.1 - 6.9e-39 131.2 28.1 1.1e-08 35.5 0.1 12.9 13 0 0 13 13 13 7 WD domain, G-beta repeat Utp12 PF04003.12 CCF34506.1 - 2e-23 82.7 0.0 3.4e-23 82.0 0.0 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.7 CCF34506.1 - 9.4e-20 70.7 0.0 0.011 16.0 0.0 10.0 5 2 5 11 11 11 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CCF34506.1 - 1.7e-08 33.8 0.2 0.64 8.9 0.0 6.3 5 2 2 7 7 7 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 CCF34506.1 - 6e-06 26.3 5.2 0.047 13.6 0.2 5.9 6 2 1 7 7 7 2 Eukaryotic translation initiation factor eIF2A Nbas_N PF15492.6 CCF34506.1 - 0.00075 18.9 0.5 2.9 7.1 0.0 4.0 3 2 1 4 4 4 2 Neuroblastoma-amplified sequence, N terminal Nup160 PF11715.8 CCF34506.1 - 0.029 13.0 3.2 6.4 5.3 0.0 3.9 3 2 1 4 4 4 0 Nucleoporin Nup120/160 PD40 PF07676.12 CCF34506.1 - 0.047 13.6 0.3 30 4.7 0.0 4.5 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Questin_oxidase PF14027.6 CCF34507.1 - 1.1e-96 324.4 1.4 1.3e-96 324.1 1.4 1.1 1 0 0 1 1 1 1 Questin oxidase-like TnpV PF14198.6 CCF34507.1 - 0.1 12.6 2.7 2.1 8.4 0.0 2.8 3 0 0 3 3 3 0 Transposon-encoded protein TnpV ACP_PD PF04336.12 CCF34507.1 - 0.27 11.7 0.1 0.27 11.7 0.1 2.2 2 0 0 2 2 2 0 Acyl carrier protein phosphodiesterase NAP PF00956.18 CCF34509.1 - 4.7e-31 107.9 6.3 3.2e-29 102.0 0.5 2.3 1 1 1 2 2 2 2 Nucleosome assembly protein (NAP) Nha1_C PF08619.10 CCF34509.1 - 0.0013 18.0 4.4 0.0016 17.7 4.4 1.1 1 0 0 1 1 1 1 Alkali metal cation/H+ antiporter Nha1 C terminus Voldacs PF03517.13 CCF34509.1 - 0.15 12.2 11.4 0.28 11.3 11.4 1.4 1 0 0 1 1 1 0 Regulator of volume decrease after cellular swelling DUF3169 PF11368.8 CCF34509.1 - 0.38 10.2 0.0 0.38 10.2 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3169) Sporozoite_P67 PF05642.11 CCF34509.1 - 7.2 4.6 7.6 3.1 5.8 0.5 2.1 2 0 0 2 2 2 0 Sporozoite P67 surface antigen SURF2 PF05477.11 CCF34509.1 - 8.7 6.0 13.9 1.7 8.3 10.4 1.6 2 0 0 2 2 2 0 Surfeit locus protein 2 (SURF2) DUF3328 PF11807.8 CCF34510.1 - 3.2e-30 105.6 6.2 4.8e-29 101.7 6.2 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF3328) Peptidase_S10 PF00450.22 CCF34511.1 - 1.5e-79 268.4 0.0 2e-79 268.0 0.0 1.2 1 0 0 1 1 1 1 Serine carboxypeptidase Sugar_tr PF00083.24 CCF34512.1 - 5.5e-48 164.0 11.2 6.9e-48 163.6 11.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF34512.1 - 9.1e-15 54.4 21.0 3e-14 52.7 21.6 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_1_like PF12832.7 CCF34512.1 - 6.4e-07 28.6 4.7 6.4e-07 28.6 4.7 1.5 2 0 0 2 2 2 1 MFS_1 like family MFS_2 PF13347.6 CCF34512.1 - 0.00014 20.6 7.2 0.00026 19.7 7.3 1.5 1 1 0 1 1 1 1 MFS/sugar transport protein Aldolase_II PF00596.21 CCF34513.1 - 5.1e-45 153.7 0.1 6.4e-45 153.4 0.1 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain TauD PF02668.16 CCF34514.1 - 2.4e-28 99.7 0.2 3.6e-28 99.1 0.2 1.3 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.12 CCF34514.1 - 7.9e-09 36.0 0.1 8.4e-08 32.8 0.1 2.5 2 1 1 3 3 3 1 Protein of unknown function (DUF971) F-box-like PF12937.7 CCF34515.1 - 3.1e-05 23.8 0.2 7e-05 22.6 0.2 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCF34515.1 - 0.0021 17.9 0.3 0.005 16.7 0.0 1.8 2 0 0 2 2 2 1 F-box domain Glyco_hydro_6 PF01341.17 CCF34518.1 - 8.7e-81 272.0 0.2 9.9e-81 271.8 0.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 6 CFEM PF05730.11 CCF34519.1 - 1.2e-09 38.1 8.3 2e-09 37.4 8.3 1.4 1 0 0 1 1 1 1 CFEM domain DUF5602 PF18197.1 CCF34519.1 - 0.0053 17.2 0.6 0.015 15.8 0.6 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF5602) SPX PF03105.19 CCF34519.1 - 1.8 8.4 8.3 2.1 8.2 8.3 1.0 1 0 0 1 1 1 0 SPX domain Ndc1_Nup PF09531.10 CCF34519.1 - 2.7 6.6 8.6 3 6.4 8.6 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Ribosomal_L22 PF00237.19 CCF34520.1 - 1.7e-22 79.6 0.0 2.9e-22 78.8 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e DUF3673 PF12425.8 CCF34520.1 - 0.15 12.0 0.2 0.5 10.3 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3673) COX6C PF02937.15 CCF34521.1 - 0.0028 17.8 0.0 0.0031 17.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIc Mitochondr_Som1 PF11093.8 CCF34522.1 - 6e-14 51.8 0.0 7.3e-14 51.5 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial export protein Som1 BCS1_N PF08740.11 CCF34524.1 - 2e-32 112.7 0.7 2.8e-32 112.2 0.7 1.2 1 0 0 1 1 1 1 BCS1 N terminal DUF3342 PF11822.8 CCF34524.1 - 0.12 12.6 0.6 0.26 11.5 0.6 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3342) DNA_pol_phi PF04931.13 CCF34526.1 - 6.4 4.7 7.6 7.5 4.5 7.6 1.0 1 0 0 1 1 1 0 DNA polymerase phi SH3_9 PF14604.6 CCF34527.1 - 2.4e-07 30.5 0.2 5.5e-07 29.4 0.2 1.7 1 0 0 1 1 1 1 Variant SH3 domain zf-C3HC4 PF00097.25 CCF34527.1 - 5.7e-07 29.3 4.2 5.7e-07 29.3 4.2 5.4 5 2 0 5 5 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CCF34527.1 - 1.3e-06 28.3 2.7 1.3e-06 28.3 2.7 5.1 5 0 0 5 5 5 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 CCF34527.1 - 6.1e-06 26.0 2.9 6.1e-06 26.0 2.9 6.0 6 2 1 7 7 5 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 CCF34527.1 - 1.9e-05 24.5 0.6 1.9e-05 24.5 0.6 3.3 4 0 0 4 4 3 1 zf-RING of BARD1-type protein SH3_1 PF00018.28 CCF34527.1 - 3.3e-05 23.4 0.0 7.2e-05 22.3 0.0 1.5 1 0 0 1 1 1 1 SH3 domain zf-RING_2 PF13639.6 CCF34527.1 - 3.6e-05 24.0 4.5 3.6e-05 24.0 4.5 5.3 4 3 1 5 5 3 1 Ring finger domain zf-RING_5 PF14634.6 CCF34527.1 - 0.00027 20.8 3.4 0.00027 20.8 3.4 6.1 6 1 1 7 7 6 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 CCF34527.1 - 0.0019 18.3 4.7 0.0019 18.3 4.7 5.4 5 2 1 6 6 6 1 zinc finger of C3HC4-type, RING Phage_sheath_1C PF17482.2 CCF34527.1 - 0.016 15.2 0.0 0.027 14.4 0.0 1.2 1 0 0 1 1 1 0 Phage tail sheath C-terminal domain SH3_2 PF07653.17 CCF34527.1 - 0.026 14.2 0.1 0.12 12.1 0.0 2.1 2 0 0 2 2 2 0 Variant SH3 domain PALP PF00291.25 CCF34528.1 - 1.8e-66 224.6 0.4 2.1e-66 224.3 0.4 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme SNF2_N PF00176.23 CCF34530.1 - 7e-63 212.4 0.1 1.3e-62 211.6 0.1 1.3 1 1 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.15 CCF34530.1 - 7.7e-08 32.5 0.0 1.6e-07 31.5 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 CCF34530.1 - 5.8e-07 29.4 0.1 2.3e-06 27.5 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_34 PF13872.6 CCF34530.1 - 0.0034 16.3 0.2 0.013 14.4 0.2 1.9 1 1 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 DEAD_2 PF06733.15 CCF34530.1 - 0.11 12.0 0.0 0.51 9.9 0.0 2.0 2 0 0 2 2 2 0 DEAD_2 Oxysterol_BP PF01237.18 CCF34531.1 - 4.6e-06 25.7 0.2 4.9e-06 25.6 0.2 1.1 1 0 0 1 1 1 1 Oxysterol-binding protein Glyco_hydro_88 PF07470.13 CCF34534.1 - 6.2e-33 114.3 0.1 6.8e-33 114.2 0.1 1.1 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 CENP-T_C PF15511.6 CCF34535.1 - 8e-09 35.6 0.1 9.7e-09 35.3 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Histone PF00125.24 CCF34535.1 - 3.5e-05 24.2 0.1 4.1e-05 23.9 0.1 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TAF PF02969.17 CCF34535.1 - 8.6e-05 22.6 0.1 0.00013 22.1 0.1 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.23 CCF34535.1 - 0.00036 20.7 0.1 0.00065 19.9 0.0 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-S PF15630.6 CCF34535.1 - 0.00042 20.7 0.1 0.00056 20.2 0.1 1.4 1 1 0 1 1 1 1 CENP-S protein TFIID-31kDa PF02291.15 CCF34535.1 - 0.0087 16.1 0.0 0.01 15.9 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 CCF34535.1 - 0.023 14.7 0.0 0.027 14.5 0.0 1.3 1 0 0 1 1 1 0 Bromodomain associated UPF0137 PF03677.13 CCF34535.1 - 0.095 12.5 0.1 0.12 12.2 0.1 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0137) HIGH_NTase1_ass PF16581.5 CCF34535.1 - 0.11 12.5 0.0 0.12 12.4 0.0 1.1 1 0 0 1 1 1 0 Cytidyltransferase-related C-terminal region Histone PF00125.24 CCF34536.1 - 1.6e-51 174.1 2.5 1.8e-51 173.9 2.5 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 CCF34536.1 - 8.4e-06 26.1 0.0 1.3e-05 25.5 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein PAF PF15715.5 CCF34536.1 - 3.4e-05 24.5 1.0 3.9e-05 24.3 1.0 1.2 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-T_C PF15511.6 CCF34536.1 - 3.6e-05 23.8 0.4 6.4e-05 23.0 0.1 1.6 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CBFD_NFYB_HMF PF00808.23 CCF34536.1 - 0.0035 17.6 0.3 0.0065 16.7 0.0 1.5 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 CCF34536.1 - 0.028 14.5 0.2 0.046 13.8 0.0 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 CCF34536.1 - 0.057 13.4 0.0 0.097 12.7 0.0 1.4 1 0 0 1 1 1 0 Bromodomain associated PRP3 PF08572.10 CCF34538.1 - 1.9e-72 243.6 10.3 1.9e-72 243.6 10.3 1.5 2 0 0 2 2 2 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.12 CCF34538.1 - 2.5e-49 167.1 3.3 2.5e-49 167.1 3.3 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1115) BLUF PF04940.12 CCF34538.1 - 0.0048 17.0 0.6 4.3 7.5 0.0 3.1 3 0 0 3 3 3 2 Sensors of blue-light using FAD GET2 PF08690.10 CCF34538.1 - 0.06 13.0 5.5 0.089 12.4 5.5 1.3 1 0 0 1 1 1 0 GET complex subunit GET2 Rgp1 PF08737.10 CCF34538.1 - 0.19 10.9 2.9 0.38 9.9 2.9 1.5 1 0 0 1 1 1 0 Rgp1 RNA_pol_Rpb1_5 PF04998.17 CCF34539.1 - 9.5e-85 284.2 0.0 1.8e-84 283.4 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 CCF34539.1 - 1.2e-67 227.3 0.4 3.5e-67 225.8 0.4 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_1 PF04997.12 CCF34539.1 - 9.5e-36 123.7 0.4 5.5e-34 117.9 0.1 3.0 2 1 0 2 2 2 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_3 PF04983.18 CCF34539.1 - 5.5e-33 114.1 0.0 1.9e-32 112.4 0.0 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 CCF34539.1 - 3.4e-17 62.4 2.0 7.4e-17 61.2 0.1 2.7 3 0 0 3 3 3 1 RNA polymerase Rpb1, domain 4 CNDH2_C PF16858.5 CCF34539.1 - 9.1 6.1 13.2 4.9 6.9 3.7 2.5 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term zf-C2H2 PF00096.26 CCF34540.1 - 3.3e-14 52.5 16.2 0.00019 21.7 0.4 3.9 3 1 1 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCF34540.1 - 1.2e-08 35.0 16.3 0.00081 20.0 0.4 4.1 4 0 0 4 4 3 3 C2H2-type zinc finger zf-H2C2_2 PF13465.6 CCF34540.1 - 0.00073 19.9 0.8 0.00073 19.9 0.8 4.0 5 0 0 5 5 4 2 Zinc-finger double domain zf-C2H2_jaz PF12171.8 CCF34540.1 - 0.011 16.1 8.1 10 6.6 0.1 4.2 2 1 1 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 CCF34540.1 - 0.041 13.9 13.2 0.066 13.2 0.1 3.9 4 0 0 4 4 4 0 C2H2-type zinc finger zf-C2H2_11 PF16622.5 CCF34540.1 - 0.044 13.5 0.2 0.044 13.5 0.2 2.7 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-met PF12874.7 CCF34540.1 - 0.058 13.8 4.8 4.8 7.7 0.1 3.9 4 0 0 4 4 4 0 Zinc-finger of C2H2 type zf-C2HC_2 PF13913.6 CCF34540.1 - 0.065 13.1 1.5 0.25 11.3 1.5 2.1 1 0 0 1 1 1 0 zinc-finger of a C2HC-type zf-BED PF02892.15 CCF34540.1 - 0.13 12.3 8.8 0.048 13.7 4.7 2.3 2 0 0 2 2 2 0 BED zinc finger zf-CHCC PF10276.9 CCF34540.1 - 0.14 12.2 1.8 0.23 11.6 0.1 2.3 2 0 0 2 2 2 0 Zinc-finger domain zf-C2H2_8 PF15909.5 CCF34540.1 - 0.36 11.1 7.2 0.33 11.3 5.0 2.0 1 1 0 2 2 2 0 C2H2-type zinc ribbon zf-C2H2_aberr PF17017.5 CCF34540.1 - 0.81 9.8 6.1 0.98 9.5 0.6 1.9 1 1 1 2 2 2 0 Aberrant zinc-finger zf-LYAR PF08790.11 CCF34540.1 - 0.83 9.6 6.4 4.1 7.4 0.1 3.7 4 0 0 4 4 4 0 LYAR-type C2HC zinc finger p450 PF00067.22 CCF34541.1 - 6.1e-46 157.1 0.0 9e-46 156.6 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 CCF34542.1 - 1.3e-35 123.1 0.0 1.6e-35 122.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 OmpH PF03938.14 CCF34543.1 - 0.0026 18.1 8.1 0.0026 18.1 8.1 1.7 1 1 1 2 2 2 1 Outer membrane protein (OmpH-like) DUF4407 PF14362.6 CCF34543.1 - 0.028 13.8 9.9 0.033 13.6 9.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) BBP1_C PF15272.6 CCF34543.1 - 0.051 13.4 3.0 0.065 13.1 2.4 1.5 1 1 1 2 2 2 0 Spindle pole body component BBP1, C-terminal GARS_A PF01071.19 CCF34543.1 - 0.17 11.7 0.3 14 5.3 0.0 2.5 1 1 2 3 3 3 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain DUF2293 PF10056.9 CCF34543.1 - 0.21 11.8 1.8 0.22 11.8 0.3 1.7 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2293) DUF5521 PF17659.1 CCF34543.1 - 0.35 8.7 1.6 0.38 8.5 1.6 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5521) CMS1 PF14617.6 CCF34544.1 - 6.6e-81 271.4 1.4 7.2e-81 271.2 1.4 1.0 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit DEAD PF00270.29 CCF34544.1 - 2e-07 30.9 0.0 3.6e-07 30.1 0.0 1.3 1 1 0 1 1 1 1 DEAD/DEAH box helicase Herpes_glycop PF01528.16 CCF34544.1 - 0.044 12.6 0.1 0.062 12.1 0.1 1.1 1 0 0 1 1 1 0 Herpesvirus glycoprotein M Pro_isomerase PF00160.21 CCF34547.1 - 1e-33 116.8 0.0 1.8e-33 116.1 0.0 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_1 PF00076.22 CCF34547.1 - 3.1e-15 55.7 0.0 5.8e-15 54.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ABC_membrane PF00664.23 CCF34548.1 - 1.1e-82 277.7 37.7 5.3e-44 150.9 14.7 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 CCF34548.1 - 2.5e-70 235.3 0.5 6.1e-34 117.5 0.0 3.2 3 1 0 3 3 3 2 ABC transporter SMC_N PF02463.19 CCF34548.1 - 1.1e-14 54.4 0.1 6.7e-05 22.4 0.0 4.2 2 2 1 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CCF34548.1 - 3.4e-08 33.1 0.7 0.0039 16.9 0.2 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain Zeta_toxin PF06414.12 CCF34548.1 - 3.7e-08 32.9 0.0 0.003 16.9 0.0 3.2 3 0 0 3 3 3 2 Zeta toxin RsgA_GTPase PF03193.16 CCF34548.1 - 4.3e-08 33.2 0.0 0.0046 16.9 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 CCF34548.1 - 7.4e-07 29.5 0.2 0.029 14.7 0.0 3.7 2 2 0 2 2 2 2 AAA domain ABC_ATPase PF09818.9 CCF34548.1 - 1.1e-06 27.8 0.7 0.07 11.9 0.1 3.6 4 0 0 4 4 4 2 Predicted ATPase of the ABC class AAA_16 PF13191.6 CCF34548.1 - 6.9e-06 26.5 2.7 0.013 15.9 0.1 3.3 3 1 0 3 3 2 2 AAA ATPase domain AAA_15 PF13175.6 CCF34548.1 - 8.5e-06 25.7 0.0 0.11 12.2 0.0 2.4 2 1 0 2 2 2 2 AAA ATPase domain AAA_25 PF13481.6 CCF34548.1 - 8.1e-05 22.3 0.1 0.26 10.8 0.1 2.6 2 0 0 2 2 2 2 AAA domain AAA_21 PF13304.6 CCF34548.1 - 0.00021 21.2 0.9 1.4 8.7 0.1 4.5 5 0 0 5 5 5 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_30 PF13604.6 CCF34548.1 - 0.00077 19.2 5.6 0.83 9.3 0.1 4.1 3 2 1 4 4 4 2 AAA domain AAA_7 PF12775.7 CCF34548.1 - 0.00085 18.9 0.4 1.5 8.3 0.0 3.1 3 0 0 3 3 3 2 P-loop containing dynein motor region AAA_23 PF13476.6 CCF34548.1 - 0.00093 19.7 1.2 1.1 9.7 0.1 2.9 3 0 0 3 3 3 1 AAA domain AAA_33 PF13671.6 CCF34548.1 - 0.00097 19.3 0.0 0.95 9.6 0.0 2.6 2 0 0 2 2 2 1 AAA domain G-alpha PF00503.20 CCF34548.1 - 0.0013 18.0 0.0 1.3 8.1 0.0 2.3 2 0 0 2 2 2 2 G-protein alpha subunit APS_kinase PF01583.20 CCF34548.1 - 0.0054 16.6 0.1 5.5 6.9 0.0 3.1 3 0 0 3 3 3 0 Adenylylsulphate kinase AAA PF00004.29 CCF34548.1 - 0.0064 16.9 0.4 8.4 6.8 0.0 3.9 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) SbcCD_C PF13558.6 CCF34548.1 - 0.011 15.9 1.4 6.9 7.0 0.1 3.6 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit RrnaAD PF00398.20 CCF34548.1 - 0.014 14.5 0.0 0.031 13.4 0.0 1.5 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase AAA_28 PF13521.6 CCF34548.1 - 0.016 15.5 0.2 0.71 10.1 0.0 2.7 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.13 CCF34548.1 - 0.019 14.1 0.0 4.7 6.3 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_5 PF07728.14 CCF34548.1 - 0.024 14.7 0.9 19 5.3 0.0 3.8 4 0 0 4 4 4 0 AAA domain (dynein-related subfamily) PRK PF00485.18 CCF34548.1 - 0.032 14.0 0.0 11 5.7 0.0 2.6 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family MMR_HSR1 PF01926.23 CCF34548.1 - 0.041 14.0 1.2 5.3 7.2 0.0 3.1 3 0 0 3 3 3 0 50S ribosome-binding GTPase NB-ARC PF00931.22 CCF34548.1 - 0.069 12.3 0.3 3.8 6.6 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain Rad17 PF03215.15 CCF34548.1 - 0.098 12.6 0.0 1.2 9.0 0.0 2.2 2 0 0 2 2 2 0 Rad17 P-loop domain Ploopntkinase3 PF18751.1 CCF34548.1 - 0.11 12.4 0.1 4.8 7.1 0.0 2.5 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 RNA_helicase PF00910.22 CCF34548.1 - 0.14 12.6 0.0 5.8 7.4 0.0 2.5 2 0 0 2 2 2 0 RNA helicase DUF87 PF01935.17 CCF34548.1 - 0.15 12.2 0.9 2.4 8.2 0.2 2.7 2 0 0 2 2 2 0 Helicase HerA, central domain SRP54 PF00448.22 CCF34548.1 - 0.21 11.2 3.0 12 5.5 0.0 2.8 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain Peptidase_M56 PF05569.11 CCF34548.1 - 9.9 5.3 8.3 9.9 5.3 0.7 2.7 3 0 0 3 3 2 0 BlaR1 peptidase M56 Glyco_hydro_43 PF04616.14 CCF34549.1 - 4.5e-15 55.7 0.6 7.1e-15 55.1 0.6 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 MctB PF11382.8 CCF34550.1 - 0.055 13.2 0.3 0.059 13.1 0.3 1.1 1 0 0 1 1 1 0 Copper transport outer membrane protein, MctB Apolipoprotein PF01442.18 CCF34551.1 - 0.0048 16.8 14.5 0.022 14.7 6.0 3.4 1 1 1 2 2 2 2 Apolipoprotein A1/A4/E domain DUF148 PF02520.17 CCF34551.1 - 0.36 11.0 6.6 0.41 10.8 0.2 3.4 2 1 1 3 3 3 0 Domain of unknown function DUF148 DUF883 PF05957.13 CCF34551.1 - 0.49 11.0 16.3 33 5.2 2.0 5.5 3 1 3 6 6 6 0 Bacterial protein of unknown function (DUF883) ApoO PF09769.9 CCF34551.1 - 0.69 9.9 4.4 17 5.4 0.3 3.8 3 1 0 3 3 3 0 Apolipoprotein O FRB_dom PF08771.11 CCF34551.1 - 7.4 7.1 6.9 16 6.0 0.1 3.5 5 1 0 5 5 5 0 FKBP12-rapamycin binding domain Bromodomain PF00439.25 CCF34552.1 - 4.7e-12 45.8 0.0 1e-11 44.7 0.0 1.6 1 0 0 1 1 1 1 Bromodomain Utp12 PF04003.12 CCF34554.1 - 5.4e-23 81.4 2.0 9.8e-23 80.5 0.3 2.0 1 1 1 2 2 2 1 Dip2/Utp12 Family BUD22 PF09073.10 CCF34554.1 - 1.8 7.8 38.7 0.3 10.4 20.6 2.1 2 0 0 2 2 2 0 BUD22 Ring_hydroxyl_A PF00848.19 CCF34556.1 - 5e-20 72.4 2.3 7.1e-12 45.7 2.8 2.3 1 1 0 2 2 2 2 Ring hydroxylating alpha subunit (catalytic domain) Rieske PF00355.26 CCF34556.1 - 1.7e-16 59.9 0.0 3.6e-16 58.9 0.0 1.5 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain CorC_HlyC PF03471.17 CCF34556.1 - 0.081 13.0 0.0 0.2 11.7 0.0 1.7 1 0 0 1 1 1 0 Transporter associated domain YppG PF14179.6 CCF34556.1 - 0.13 13.0 0.2 1.2 9.9 0.0 2.1 2 0 0 2 2 2 0 YppG-like protein MTP18 PF10558.9 CCF34557.1 - 1.1e-64 217.5 0.4 1.5e-64 217.1 0.4 1.1 1 0 0 1 1 1 1 Mitochondrial 18 KDa protein (MTP18) ATP19 PF11022.8 CCF34558.1 - 4.4e-29 100.6 0.1 5e-29 100.5 0.1 1.0 1 0 0 1 1 1 1 ATP synthase subunit K SGL PF08450.12 CCF34559.1 - 8e-13 48.5 0.0 1.6e-12 47.5 0.0 1.5 1 1 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 CCF34559.1 - 0.0023 18.1 0.0 0.0051 17.0 0.0 1.5 1 0 0 1 1 1 1 Arylesterase NHL PF01436.21 CCF34559.1 - 0.003 17.5 2.0 0.85 9.8 0.1 3.4 4 0 0 4 4 4 2 NHL repeat 2OG-FeII_Oxy_2 PF13532.6 CCF34561.1 - 1.6e-30 106.8 0.0 2.5e-30 106.1 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Isochorismatase PF00857.20 CCF34561.1 - 9.6e-25 87.8 0.2 3.5e-24 85.9 0.2 1.9 1 1 0 1 1 1 1 Isochorismatase family GST_C PF00043.25 CCF34561.1 - 0.00042 20.5 0.0 0.001 19.2 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CCF34561.1 - 0.0011 18.9 0.0 0.0026 17.7 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 CCF34561.1 - 0.014 15.6 0.0 0.034 14.3 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain SHMT PF00464.19 CCF34562.1 - 1.8e-195 649.2 0.0 2.1e-195 649.0 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase DegT_DnrJ_EryC1 PF01041.17 CCF34562.1 - 0.00035 20.0 0.0 0.00053 19.4 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.21 CCF34562.1 - 0.00096 18.5 0.0 0.0019 17.5 0.0 1.4 1 1 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 CCF34562.1 - 0.0037 16.5 0.0 0.012 14.8 0.0 1.8 1 1 0 1 1 1 1 Aminotransferase class I and II adh_short PF00106.25 CCF34563.1 - 1.6e-25 89.7 0.0 1e-21 77.3 0.0 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCF34563.1 - 2.5e-13 50.2 0.0 1.4e-12 47.7 0.0 2.0 2 1 1 3 3 3 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF34563.1 - 6.1e-08 32.8 0.0 1.1e-07 32.0 0.0 1.3 1 0 0 1 1 1 1 KR domain ADH_zinc_N PF00107.26 CCF34563.1 - 0.0077 16.2 0.0 0.017 15.1 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase GDP_Man_Dehyd PF16363.5 CCF34563.1 - 0.014 14.8 0.0 0.022 14.1 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Fungal_trans_2 PF11951.8 CCF34564.1 - 3e-06 26.3 0.6 4e-06 25.9 0.6 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain FAD_binding_4 PF01565.23 CCF34565.1 - 4e-13 49.3 0.9 4e-13 49.3 0.9 1.7 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.12 CCF34565.1 - 2.4e-11 43.6 0.3 2.4e-11 43.6 0.3 1.7 2 0 0 2 2 2 1 Berberine and berberine like ThiF PF00899.21 CCF34568.1 - 7.3e-42 143.4 0.0 1.2e-41 142.7 0.0 1.2 1 0 0 1 1 1 1 ThiF family Sacchrp_dh_NADP PF03435.18 CCF34568.1 - 5.9e-07 29.8 0.0 1.3e-06 28.7 0.0 1.6 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain TrkA_N PF02254.18 CCF34568.1 - 0.012 15.8 0.2 0.047 14.0 0.1 2.1 2 0 0 2 2 2 0 TrkA-N domain NAD_binding_7 PF13241.6 CCF34568.1 - 0.021 15.2 0.0 0.059 13.8 0.0 1.7 1 0 0 1 1 1 0 Putative NAD(P)-binding UDPG_MGDP_dh_N PF03721.14 CCF34568.1 - 0.044 13.4 0.1 0.084 12.4 0.1 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ALO PF04030.14 CCF34569.1 - 5e-69 233.0 0.0 7.7e-63 212.7 0.0 2.1 1 1 1 2 2 2 2 D-arabinono-1,4-lactone oxidase FAD_binding_4 PF01565.23 CCF34569.1 - 1.3e-06 28.2 0.0 1.5e-05 24.8 0.0 2.2 1 1 0 1 1 1 1 FAD binding domain Not3 PF04065.15 CCF34570.1 - 0.035 13.5 0.0 0.047 13.1 0.0 1.3 1 0 0 1 1 1 0 Not1 N-terminal domain, CCR4-Not complex component ZapA PF05164.13 CCF34570.1 - 0.092 13.2 0.5 0.18 12.2 0.5 1.5 1 1 0 1 1 1 0 Cell division protein ZapA UreE_C PF05194.12 CCF34570.1 - 0.24 11.9 16.6 0.5 10.9 15.9 2.0 1 1 0 1 1 1 0 UreE urease accessory protein, C-terminal domain Lipase_GDSL PF00657.22 CCF34571.1 - 1.1e-11 45.1 0.1 1.9e-11 44.3 0.1 1.4 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 CCF34571.1 - 1.3e-11 45.2 0.8 2.6e-11 44.2 0.8 1.5 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family F-box-like PF12937.7 CCF34572.1 - 3.5e-06 26.8 0.1 4.8e-06 26.4 0.1 1.2 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCF34572.1 - 5.2e-05 23.0 0.1 7.8e-05 22.4 0.1 1.3 1 0 0 1 1 1 1 F-box domain HAGH_C PF16123.5 CCF34572.1 - 0.037 14.5 0.0 0.053 14.0 0.0 1.3 1 0 0 1 1 1 0 Hydroxyacylglutathione hydrolase C-terminus PcrB PF01884.17 CCF34572.1 - 0.15 11.5 0.1 0.21 11.0 0.1 1.1 1 0 0 1 1 1 0 PcrB family RRM_1 PF00076.22 CCF34573.1 - 0.2 11.5 0.0 0.43 10.5 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Trp_DMAT PF11991.8 CCF34575.1 - 1.4e-111 373.5 0.0 1.8e-111 373.1 0.0 1.1 1 0 0 1 1 1 1 Tryptophan dimethylallyltransferase Condensation PF00668.20 CCF34576.1 - 2.5e-60 204.5 0.0 4.1e-32 111.5 0.0 2.5 2 1 0 2 2 2 2 Condensation domain AMP-binding PF00501.28 CCF34576.1 - 1.3e-36 126.1 0.0 2.8e-32 111.9 0.0 2.2 2 0 0 2 2 2 2 AMP-binding enzyme PP-binding PF00550.25 CCF34576.1 - 1.1e-26 92.9 0.1 4.2e-12 46.2 0.0 2.7 2 0 0 2 2 2 2 Phosphopantetheine attachment site JmjN PF02375.17 CCF34576.1 - 0.024 14.6 0.5 0.24 11.4 0.1 2.4 2 0 0 2 2 2 0 jmjN domain WES_acyltransf PF03007.16 CCF34576.1 - 0.081 12.7 0.1 1.3 8.7 0.1 2.4 2 0 0 2 2 2 0 Wax ester synthase-like Acyl-CoA acyltransferase domain HNH_2 PF13391.6 CCF34578.1 - 4.7e-11 42.7 0.0 1.2e-10 41.4 0.0 1.7 2 0 0 2 2 2 1 HNH endonuclease Swi6_N PF18530.1 CCF34578.1 - 0.18 11.9 0.0 0.29 11.3 0.0 1.4 1 0 0 1 1 1 0 Swi6 N-terminal domain HAMP_N3 PF18575.1 CCF34579.1 - 0.00091 18.8 0.0 0.0015 18.1 0.0 1.4 1 0 0 1 1 1 1 HAMP N-terminal domain 3 Aminotran_4 PF01063.19 CCF34579.1 - 0.19 11.6 0.0 0.31 10.9 0.0 1.2 1 0 0 1 1 1 0 Amino-transferase class IV NACHT PF05729.12 CCF34581.1 - 1.2e-08 35.0 0.0 2.1e-08 34.2 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 CCF34581.1 - 4.5e-06 27.1 0.1 1.4e-05 25.5 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 CCF34581.1 - 5.2e-05 23.5 0.0 0.00016 21.9 0.0 1.8 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 CCF34581.1 - 0.0002 21.2 0.0 0.00032 20.5 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein APS_kinase PF01583.20 CCF34581.1 - 0.0076 16.1 0.0 0.017 15.0 0.0 1.6 1 0 0 1 1 1 1 Adenylylsulphate kinase RNA_helicase PF00910.22 CCF34581.1 - 0.016 15.6 0.0 0.036 14.4 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_33 PF13671.6 CCF34581.1 - 0.035 14.3 0.0 0.085 13.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 CCF34581.1 - 0.066 12.7 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_18 PF13238.6 CCF34581.1 - 0.085 13.4 0.0 0.51 10.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain Cytidylate_kin PF02224.18 CCF34581.1 - 0.1 12.3 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 Cytidylate kinase NB-ARC PF00931.22 CCF34581.1 - 0.17 11.0 0.0 0.31 10.2 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain AAA_30 PF13604.6 CCF34581.1 - 0.19 11.4 0.0 0.32 10.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain DEAD PF00270.29 CCF34582.1 - 1.3e-09 38.0 0.1 3.5e-09 36.7 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF34582.1 - 3.3e-05 24.2 0.1 0.00012 22.4 0.1 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HHH_5 PF14520.6 CCF34582.1 - 0.015 15.9 0.0 0.065 13.8 0.0 2.0 2 0 0 2 2 2 0 Helix-hairpin-helix domain BTB PF00651.31 CCF34584.1 - 0.00049 20.3 0.1 0.0017 18.6 0.0 1.8 2 0 0 2 2 2 1 BTB/POZ domain NAD_binding_6 PF08030.12 CCF34586.1 - 2.6e-17 63.4 0.0 4e-17 62.8 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 CCF34586.1 - 4.7e-13 49.3 10.8 4.7e-13 49.3 10.8 1.9 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_1 PF00175.21 CCF34586.1 - 2e-05 25.2 0.0 0.00031 21.4 0.0 2.5 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_8 PF08022.12 CCF34586.1 - 2.1e-05 24.6 0.0 0.0021 18.1 0.0 2.8 2 1 0 2 2 2 1 FAD-binding domain 6PF2K PF01591.18 CCF34588.1 - 4.3e-50 170.1 0.1 1.8e-49 168.0 0.1 1.9 1 1 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 CCF34588.1 - 1.7e-21 76.8 0.1 8.5e-21 74.5 0.1 2.0 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) ZnuA PF01297.17 CCF34588.1 - 0.12 11.8 0.1 0.39 10.1 0.0 1.9 1 1 1 2 2 2 0 Zinc-uptake complex component A periplasmic UCH_1 PF13423.6 CCF34589.1 - 1.8e-39 136.2 0.0 8.3e-39 134.0 0.0 1.9 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase SelP_N PF04592.14 CCF34589.1 - 1.1 8.6 5.9 2.4 7.5 5.9 1.6 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Methyltransf_22 PF13383.6 CCF34590.1 - 1e-18 67.9 0.0 1.4e-18 67.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_21 PF05050.12 CCF34590.1 - 4.4e-06 26.8 0.0 6.4e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase FkbM domain p450 PF00067.22 CCF34591.1 - 4.4e-21 75.2 0.0 5.6e-21 74.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 BCS1_N PF08740.11 CCF34592.1 - 4.6e-23 82.2 0.1 8.6e-23 81.3 0.1 1.5 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 CCF34592.1 - 1.4e-17 64.4 0.1 1.5e-16 61.0 0.0 2.5 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 CCF34592.1 - 0.003 17.3 0.0 0.0052 16.6 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 CCF34592.1 - 0.0033 17.8 0.1 0.01 16.2 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 CCF34592.1 - 0.02 15.4 0.2 0.063 13.8 0.0 1.9 2 1 0 2 2 2 0 AAA domain ATPase PF06745.13 CCF34592.1 - 0.052 12.9 0.0 0.099 12.0 0.0 1.4 1 0 0 1 1 1 0 KaiC AAA_5 PF07728.14 CCF34592.1 - 0.06 13.3 0.1 0.26 11.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) zf-C2H2_4 PF13894.6 CCF34594.1 - 8.4e-08 32.4 11.5 0.021 15.7 0.1 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2 PF00096.26 CCF34594.1 - 2.7e-06 27.5 17.8 0.005 17.2 0.2 3.9 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 CCF34594.1 - 0.00021 21.5 9.6 0.36 11.2 0.2 3.4 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 CCF34594.1 - 0.014 15.4 11.1 0.69 10.0 0.4 3.7 3 1 0 3 3 3 0 C2H2-type zinc finger zf-met PF12874.7 CCF34594.1 - 0.072 13.5 8.0 1.6 9.2 0.2 3.1 3 0 0 3 3 3 0 Zinc-finger of C2H2 type CAP_N PF01213.19 CCF34596.1 - 0.4 10.1 3.6 0.61 9.5 3.6 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Fcf1 PF04900.12 CCF34598.1 - 0.00072 19.9 0.3 0.0015 18.9 0.3 1.6 1 0 0 1 1 1 1 Fcf1 CDC45 PF02724.14 CCF34598.1 - 1.2 7.4 6.7 1.4 7.1 6.7 1.1 1 0 0 1 1 1 0 CDC45-like protein SRP-alpha_N PF04086.13 CCF34598.1 - 7.8 6.3 18.4 9.2 6.1 18.4 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal DUF726 PF05277.12 CCF34599.1 - 4.1e-126 420.5 1.2 5.8e-126 420.0 1.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF726) FliT PF05400.13 CCF34599.1 - 7.8 7.4 9.7 2.3 9.1 1.1 3.1 2 0 0 2 2 2 0 Flagellar protein FliT Usp PF00582.26 CCF34600.1 - 6.4e-24 85.1 5.3 1.6e-15 57.9 0.4 2.9 3 0 0 3 3 3 2 Universal stress protein family AglB_L1 PF18079.1 CCF34602.1 - 2.3 8.5 6.4 0.63 10.4 2.4 2.2 2 0 0 2 2 2 0 Archaeal glycosylation protein B long peripheral domain PTPA PF03095.15 CCF34603.1 - 2.7e-113 378.4 0.0 3.2e-113 378.2 0.0 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein RNase_PH PF01138.21 CCF34604.1 - 3.7e-13 50.1 0.0 5.6e-13 49.5 0.0 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 CCF34604.1 - 0.021 14.8 0.1 0.092 12.8 0.0 2.0 2 0 0 2 2 2 0 3' exoribonuclease family, domain 2 Adaptin_N PF01602.20 CCF34606.1 - 3.9e-115 385.4 0.7 5e-115 385.0 0.7 1.1 1 0 0 1 1 1 1 Adaptin N terminal region COP-gamma_platf PF08752.10 CCF34606.1 - 2.4e-55 186.8 6.7 6.2e-55 185.5 6.7 1.8 1 0 0 1 1 1 1 Coatomer gamma subunit appendage platform subdomain Coatomer_g_Cpla PF16381.5 CCF34606.1 - 1.6e-37 128.1 0.3 4.8e-37 126.6 0.3 1.9 1 0 0 1 1 1 1 Coatomer subunit gamma-1 C-terminal appendage platform HEAT_2 PF13646.6 CCF34606.1 - 7.8e-18 64.6 1.0 3.4e-12 46.6 0.0 5.1 2 1 3 5 5 5 1 HEAT repeats Cnd1 PF12717.7 CCF34606.1 - 5.5e-07 29.8 9.7 0.047 13.7 0.1 4.9 4 1 1 5 5 5 2 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 CCF34606.1 - 0.0019 17.8 5.8 0.005 16.4 0.2 3.2 4 0 0 4 4 4 1 CLASP N terminal HEAT_PBS PF03130.16 CCF34606.1 - 0.002 18.6 0.1 1.5 9.7 0.0 4.1 3 0 0 3 3 3 1 PBS lyase HEAT-like repeat Coatomer_b_Cpla PF14806.6 CCF34606.1 - 0.034 14.1 0.0 0.21 11.5 0.0 2.3 2 0 0 2 2 2 0 Coatomer beta subunit appendage platform RTP1_C1 PF10363.9 CCF34606.1 - 0.069 13.3 0.6 4.3 7.6 0.0 3.5 3 0 0 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 DUF5010 PF16402.5 CCF34606.1 - 0.069 12.0 0.0 0.14 10.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5010) HEAT PF02985.22 CCF34606.1 - 0.14 12.5 8.5 2.2 8.8 0.2 5.3 5 0 0 5 5 5 0 HEAT repeat HEAT_EZ PF13513.6 CCF34606.1 - 0.75 10.4 2.8 1.5 9.5 0.6 2.7 2 0 0 2 2 2 0 HEAT-like repeat CDP-OH_P_transf PF01066.21 CCF34607.1 - 2.3e-17 63.5 0.1 2.3e-17 63.5 0.1 3.1 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase DUF3433 PF11915.8 CCF34608.1 - 1.5e-37 127.9 18.8 3.1e-19 69.2 2.3 3.5 3 0 0 3 3 3 2 Protein of unknown function (DUF3433) stn_TNFRSF12A PF12191.8 CCF34608.1 - 0.023 14.9 0.0 0.059 13.6 0.0 1.6 1 0 0 1 1 1 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain CBS PF00571.28 CCF34609.1 - 2.4e-26 91.9 7.7 7.6e-12 45.5 0.4 4.4 4 0 0 4 4 4 4 CBS domain Acyltransferase PF01553.21 CCF34610.1 - 1.3e-05 24.8 0.0 2.4e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase ABC2_membrane_4 PF12730.7 CCF34610.1 - 0.34 10.9 4.4 2.6 8.0 0.4 2.4 2 0 0 2 2 2 0 ABC-2 family transporter protein Suc_Fer-like PF06999.12 CCF34611.1 - 1.1e-71 240.8 0.0 1.2e-71 240.6 0.0 1.0 1 0 0 1 1 1 1 Sucrase/ferredoxin-like Drf_GBD PF06371.13 CCF34612.1 - 9.7e-16 57.9 0.9 2.9e-14 53.1 0.9 2.4 1 1 0 1 1 1 1 Diaphanous GTPase-binding Domain DUF3535 PF12054.8 CCF34613.1 - 1e-127 427.1 0.1 5.7e-127 424.6 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3535) SNF2_N PF00176.23 CCF34613.1 - 5.5e-65 219.4 0.0 1.4e-64 218.1 0.0 1.6 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CCF34613.1 - 3.4e-19 69.2 0.0 8.7e-19 67.9 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HEAT PF02985.22 CCF34613.1 - 4.4e-16 57.6 5.0 0.035 14.3 0.0 8.8 9 0 0 9 9 9 4 HEAT repeat HEAT_2 PF13646.6 CCF34613.1 - 3.2e-08 33.8 2.6 0.0026 18.1 0.0 6.2 6 0 0 6 6 6 1 HEAT repeats Vac14_Fab1_bd PF12755.7 CCF34613.1 - 2.3e-06 28.1 0.2 0.25 11.9 0.0 3.8 2 1 1 3 3 3 2 Vacuolar 14 Fab1-binding region UME PF08064.13 CCF34613.1 - 0.011 15.7 0.3 14 5.7 0.0 4.8 5 2 0 5 5 5 0 UME (NUC010) domain HEAT_EZ PF13513.6 CCF34613.1 - 0.032 14.7 9.0 5.5 7.6 0.0 6.9 9 0 0 9 9 9 0 HEAT-like repeat PsiE PF06146.12 CCF34613.1 - 0.073 13.5 0.0 0.19 12.1 0.0 1.7 1 0 0 1 1 1 0 Phosphate-starvation-inducible E ERCC3_RAD25_C PF16203.5 CCF34613.1 - 0.14 11.3 0.0 0.29 10.3 0.0 1.4 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase Fungal_trans_2 PF11951.8 CCF34615.1 - 8.3e-42 143.4 0.1 1e-41 143.1 0.1 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain PhyH PF05721.13 CCF34616.1 - 1.3e-18 68.0 0.2 1.7e-18 67.6 0.2 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Brix PF04427.18 CCF34617.1 - 1.7e-44 152.2 0.0 2.4e-44 151.7 0.0 1.2 1 0 0 1 1 1 1 Brix domain DUF1168 PF06658.12 CCF34617.1 - 6.3 6.6 20.1 0.08 12.8 9.6 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1168) DEAD PF00270.29 CCF34618.1 - 8.2e-47 159.2 0.0 1.3e-46 158.6 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF34618.1 - 1.8e-31 108.7 0.4 1.3e-30 106.0 0.1 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCF34618.1 - 4.3e-07 30.1 0.0 8.3e-07 29.2 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit RcsF PF16358.5 CCF34618.1 - 0.08 13.0 0.1 0.17 12.0 0.1 1.5 1 0 0 1 1 1 0 RcsF lipoprotein Kinesin PF00225.23 CCF34619.1 - 7e-57 192.8 0.0 1.1e-56 192.3 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 CCF34619.1 - 1.5e-11 44.4 0.0 7.9e-09 35.6 0.0 2.4 2 0 0 2 2 2 2 Microtubule binding Arm_APC_u3 PF16629.5 CCF34619.1 - 0.033 13.8 0.1 0.07 12.7 0.1 1.5 1 0 0 1 1 1 0 Armadillo-associated region on APC NRBF2 PF08961.10 CCF34619.1 - 1.9 8.0 8.5 0.047 13.3 1.3 2.0 2 0 0 2 2 2 0 Nuclear receptor-binding factor 2, autophagy regulator Bac_rhodopsin PF01036.18 CCF34620.1 - 2.3e-61 207.2 12.7 3e-61 206.8 12.7 1.0 1 0 0 1 1 1 1 Bacteriorhodopsin-like protein DUF3852 PF12963.7 CCF34620.1 - 0.12 12.8 2.1 1.4 9.3 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3852) Arteri_Gl PF00951.18 CCF34620.1 - 3.2 7.5 6.8 0.33 10.7 2.3 1.6 2 0 0 2 2 2 0 Arterivirus GL envelope glycoprotein Pkinase PF00069.25 CCF34621.1 - 0.2 11.0 0.0 0.22 10.8 0.0 1.1 1 0 0 1 1 1 0 Protein kinase domain GCP_C_terminal PF04130.13 CCF34622.1 - 8e-101 337.6 0.0 1.2e-100 337.0 0.0 1.3 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 CCF34622.1 - 5.3e-85 285.7 0.0 1.8e-84 284.0 0.0 1.8 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal SAGA-Tad1 PF12767.7 CCF34623.1 - 2.4e-62 210.8 0.0 3.4e-62 210.2 0.0 1.2 1 0 0 1 1 1 1 Transcriptional regulator of RNA polII, SAGA, subunit ChiW_Ig_like PF18683.1 CCF34624.1 - 0.058 13.6 0.0 0.088 13.0 0.0 1.3 1 0 0 1 1 1 0 Chitinase W immunoglobulin-like domain Mito_carr PF00153.27 CCF34626.1 - 1.9e-23 82.2 2.1 7.2e-12 45.1 0.4 2.1 2 0 0 2 2 2 2 Mitochondrial carrier protein DUF4203 PF13886.6 CCF34626.1 - 0.04 13.6 0.9 1.2 8.7 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4203) Ribonuclease_3 PF00636.26 CCF34628.1 - 1.1e-37 128.8 0.0 2.2e-19 70.0 0.0 2.7 2 0 0 2 2 2 2 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 CCF34628.1 - 4.1e-23 82.0 0.0 1e-10 41.9 0.0 3.6 3 0 0 3 3 3 3 Ribonuclease-III-like Dicer_dimer PF03368.14 CCF34628.1 - 2.8e-22 78.7 0.5 1.3e-21 76.5 0.0 2.4 3 0 0 3 3 3 1 Dicer dimerisation domain Helicase_C PF00271.31 CCF34628.1 - 6.2e-18 65.2 0.1 1.6e-17 63.8 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 CCF34628.1 - 1.1e-14 54.6 0.0 2.1e-14 53.7 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 CCF34628.1 - 1.5e-10 41.4 0.0 3.6e-10 40.1 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD_2 PF06733.15 CCF34628.1 - 0.00014 21.5 0.0 0.0024 17.5 0.0 2.4 2 0 0 2 2 2 1 DEAD_2 SprT-like PF10263.9 CCF34629.1 - 9.1e-15 54.5 0.2 1.5e-14 53.8 0.2 1.3 1 0 0 1 1 1 1 SprT-like family Peptidase_M50 PF02163.22 CCF34629.1 - 0.24 10.6 0.2 0.35 10.1 0.2 1.2 1 0 0 1 1 1 0 Peptidase family M50 SprT-like PF10263.9 CCF34630.1 - 0.057 13.3 0.6 0.13 12.1 0.2 1.9 2 1 0 2 2 2 0 SprT-like family BSP PF04450.12 CCF34630.1 - 0.16 11.7 0.0 0.27 11.0 0.0 1.3 1 0 0 1 1 1 0 Peptidase of plants and bacteria Aquarius_N PF16399.5 CCF34632.1 - 0 1116.7 0.0 0 1116.3 0.0 1.1 1 0 0 1 1 1 1 Intron-binding protein aquarius N-terminus AAA_12 PF13087.6 CCF34632.1 - 3.1e-26 92.2 0.0 6.1e-26 91.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 CCF34632.1 - 1.4e-20 74.2 0.0 4.7e-20 72.5 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CCF34632.1 - 8.1e-08 32.2 0.0 0.00028 20.7 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 CCF34632.1 - 4.7e-06 27.0 0.0 1e-05 25.9 0.0 1.6 1 1 0 1 1 1 1 AAA domain ResIII PF04851.15 CCF34632.1 - 6.9e-06 26.2 0.0 1.5e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_16 PF13191.6 CCF34632.1 - 0.0011 19.4 1.0 0.0082 16.5 0.0 3.0 3 0 0 3 3 2 1 AAA ATPase domain AAA PF00004.29 CCF34632.1 - 0.002 18.5 0.0 0.0073 16.7 0.0 2.0 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DnaB_C PF03796.15 CCF34632.1 - 0.0021 17.4 0.0 0.0049 16.2 0.0 1.6 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain Viral_helicase1 PF01443.18 CCF34632.1 - 0.003 17.3 0.3 0.34 10.6 0.0 2.9 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase PIF1 PF05970.14 CCF34632.1 - 0.012 14.8 0.0 1.9 7.6 0.0 2.2 2 0 0 2 2 2 0 PIF1-like helicase UvrD_C_2 PF13538.6 CCF34632.1 - 0.019 14.8 0.6 0.099 12.5 0.1 2.3 2 0 0 2 2 2 0 UvrD-like helicase C-terminal domain DEAD PF00270.29 CCF34632.1 - 0.027 14.3 0.0 0.058 13.2 0.0 1.5 1 0 0 1 1 1 0 DEAD/DEAH box helicase UvrD-helicase PF00580.21 CCF34632.1 - 0.049 13.2 0.2 0.5 9.8 0.0 2.3 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain DUF2075 PF09848.9 CCF34632.1 - 0.053 12.8 1.1 0.083 12.1 0.0 1.8 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.6 CCF34632.1 - 0.062 13.6 0.0 0.22 11.8 0.0 1.9 1 0 0 1 1 1 0 AAA domain DNA_pack_N PF02500.15 CCF34632.1 - 0.14 11.9 0.3 0.37 10.6 0.3 1.6 1 0 0 1 1 1 0 Probable DNA packing protein, N-terminus efThoc1 PF11957.8 CCF34633.1 - 1.6e-78 264.6 0.5 2e-78 264.3 0.5 1.1 1 0 0 1 1 1 1 THO complex subunit 1 transcription elongation factor FA_hydroxylase PF04116.13 CCF34635.1 - 1.2e-11 45.1 15.2 1.2e-11 45.0 10.2 2.7 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily zf-RING_2 PF13639.6 CCF34637.1 - 1.9e-13 50.5 7.0 1.9e-13 50.5 7.0 2.3 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 CCF34637.1 - 6.7e-12 45.1 9.3 7.2e-09 35.4 2.4 2.2 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CCF34637.1 - 1.5e-10 40.7 16.9 1.5e-09 37.5 6.4 2.3 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 CCF34637.1 - 1.3e-09 37.6 2.3 1.3e-09 37.6 2.3 2.9 3 0 0 3 3 3 1 RING-like zinc finger zf-C3HC4 PF00097.25 CCF34637.1 - 8.8e-09 35.1 13.6 1.1e-06 28.4 5.0 2.3 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 CCF34637.1 - 1.1e-06 28.8 7.0 1.1e-06 28.8 7.0 2.4 2 0 0 2 2 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 CCF34637.1 - 1.4e-06 28.2 3.7 1.4e-06 28.2 3.7 2.3 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 CCF34637.1 - 1.8e-05 24.5 13.0 7.5e-05 22.5 5.1 2.3 2 0 0 2 2 2 2 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 CCF34637.1 - 2.8e-05 24.0 0.9 2.8e-05 24.0 0.9 2.9 2 1 1 3 3 3 1 RING-type zinc-finger HypA PF01155.19 CCF34637.1 - 0.0021 18.1 0.4 0.0021 18.1 0.4 2.0 2 0 0 2 2 2 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-ANAPC11 PF12861.7 CCF34637.1 - 0.0028 17.7 3.9 0.0028 17.7 3.9 2.0 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.6 CCF34637.1 - 0.033 14.3 13.8 0.36 11.0 1.9 3.2 2 1 1 3 3 3 0 zinc finger of C3HC4-type, RING DZR PF12773.7 CCF34637.1 - 0.11 12.5 4.3 2.5 8.2 0.5 2.4 2 0 0 2 2 2 0 Double zinc ribbon DNA_ligase_ZBD PF03119.16 CCF34637.1 - 0.13 12.3 1.9 4.1 7.5 0.2 2.6 2 0 0 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain Prok-RING_1 PF14446.6 CCF34637.1 - 0.15 12.0 12.5 0.62 10.0 1.9 3.4 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 zf-FPG_IleRS PF06827.14 CCF34637.1 - 0.24 11.3 5.2 2.4 8.1 0.1 2.9 3 0 0 3 3 3 0 Zinc finger found in FPG and IleRS zinc_ribbon_9 PF14369.6 CCF34637.1 - 0.45 10.8 8.7 1 9.7 5.7 2.6 2 0 0 2 2 2 0 zinc-ribbon PhnA_Zn_Ribbon PF08274.12 CCF34637.1 - 0.64 10.0 3.8 18 5.4 0.4 2.5 2 0 0 2 2 2 0 PhnA Zinc-Ribbon PHD PF00628.29 CCF34637.1 - 0.67 9.9 14.6 2.9 7.9 1.8 2.5 2 0 0 2 2 2 0 PHD-finger zinc-ribbons_6 PF07191.12 CCF34637.1 - 0.81 9.7 9.3 0.65 10.0 1.3 2.4 2 1 0 2 2 2 0 zinc-ribbons zf-RING_4 PF14570.6 CCF34637.1 - 2.9 7.8 14.2 0.55 10.1 4.3 2.3 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-P11 PF03854.14 CCF34637.1 - 3.4 7.4 8.1 0.079 12.6 1.4 1.7 2 0 0 2 2 1 0 P-11 zinc finger Zn_ribbon_17 PF17120.5 CCF34637.1 - 7.3 6.3 16.8 6.2 6.5 5.8 2.4 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type Zn-ribbon_8 PF09723.10 CCF34637.1 - 9.8 6.4 6.3 10 6.3 0.5 2.7 2 0 0 2 2 2 0 Zinc ribbon domain PYC_OADA PF02436.18 CCF34639.1 - 3.3e-69 232.6 0.0 6e-69 231.8 0.0 1.4 1 0 0 1 1 1 1 Conserved carboxylase domain HMGL-like PF00682.19 CCF34639.1 - 3.7e-21 75.9 0.3 6.5e-21 75.1 0.3 1.3 1 0 0 1 1 1 1 HMGL-like Biotin_lipoyl PF00364.22 CCF34639.1 - 3.4e-19 68.5 4.2 7.4e-19 67.4 1.9 2.5 2 0 0 2 2 2 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 CCF34639.1 - 7.9e-12 44.8 1.8 1.5e-06 27.9 0.1 3.5 2 1 1 3 3 3 2 Biotin-lipoyl like HlyD_D23 PF16576.5 CCF34639.1 - 4.4e-05 22.8 0.1 0.015 14.5 0.0 2.4 1 1 1 2 2 2 2 Barrel-sandwich domain of CusB or HlyD membrane-fusion HlyD_3 PF13437.6 CCF34639.1 - 0.00038 21.1 0.4 2.6 8.8 0.0 3.3 3 0 0 3 3 3 2 HlyD family secretion protein DUF2118 PF09891.9 CCF34639.1 - 0.001 19.1 0.1 0.0064 16.5 0.1 2.2 2 0 0 2 2 2 1 Uncharacterized protein conserved in archaea (DUF2118) GCV_H PF01597.19 CCF34639.1 - 0.0098 15.8 0.9 0.068 13.1 0.2 2.5 2 1 1 3 3 3 1 Glycine cleavage H-protein NQRA PF05896.11 CCF34639.1 - 0.043 13.3 0.2 0.074 12.5 0.2 1.3 1 0 0 1 1 1 0 Na(+)-translocating NADH-quinone reductase subunit A (NQRA) PYNP_C PF07831.13 CCF34639.1 - 0.045 13.4 1.7 0.44 10.2 0.0 3.0 3 0 0 3 3 3 0 Pyrimidine nucleoside phosphorylase C-terminal domain RnfC_N PF13375.6 CCF34639.1 - 0.061 13.3 0.3 0.13 12.2 0.3 1.6 1 0 0 1 1 1 0 RnfC Barrel sandwich hybrid domain Proteasome PF00227.26 CCF34640.1 - 1.4e-43 148.6 1.5 3e-27 95.3 0.0 3.1 4 0 0 4 4 4 2 Proteasome subunit Proteasome_A_N PF10584.9 CCF34640.1 - 5.3e-12 45.2 1.0 6.1e-12 45.0 0.0 1.6 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature Arm-DNA-bind_3 PF13356.6 CCF34640.1 - 0.58 10.6 3.1 8.9 6.8 0.1 3.0 2 1 1 3 3 3 0 Arm DNA-binding domain Glycoprot_B_PH1 PF17416.2 CCF34641.1 - 0.1 12.2 0.3 0.14 11.8 0.3 1.2 1 0 0 1 1 1 0 Herpesvirus Glycoprotein B MAJIN PF15077.6 CCF34641.1 - 0.12 12.1 1.3 0.2 11.4 1.3 1.3 1 0 0 1 1 1 0 Membrane-anchored junction protein CBP4 PF07960.11 CCF34641.1 - 5.4 6.9 11.1 2.1 8.2 7.3 2.2 2 1 1 3 3 3 0 CBP4 UQ_con PF00179.26 CCF34642.1 - 1.5e-32 112.2 0.0 1.8e-32 111.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme DUF572 PF04502.13 CCF34643.1 - 1e-67 229.1 0.0 1.2e-67 228.9 0.0 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) PGBA_N PF15436.6 CCF34645.1 - 0.18 11.4 0.0 0.24 11.0 0.0 1.2 1 0 0 1 1 1 0 Plasminogen-binding protein pgbA N-terminal MFS_1 PF07690.16 CCF34646.1 - 3.3e-46 157.8 38.0 3.3e-46 157.8 38.0 2.8 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF34646.1 - 9.5e-13 47.8 28.4 3e-10 39.6 10.2 3.4 3 1 0 3 3 3 2 Sugar (and other) transporter DUF697 PF05128.12 CCF34646.1 - 0.043 13.5 0.8 0.043 13.5 0.8 3.0 4 0 0 4 4 4 0 Domain of unknown function (DUF697) OATP PF03137.20 CCF34646.1 - 0.74 8.0 12.7 0.15 10.3 5.7 2.5 2 1 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Phage_holin_3_2 PF04550.12 CCF34646.1 - 0.8 10.3 7.5 0.26 11.8 2.8 2.8 2 0 0 2 2 2 0 Phage holin family 2 MFS_1_like PF12832.7 CCF34646.1 - 3.5 6.4 22.8 0.19 10.6 6.8 2.4 3 0 0 3 3 3 0 MFS_1 like family HD_3 PF13023.6 CCF34649.1 - 1.3e-49 168.3 0.0 1.6e-49 168.0 0.0 1.1 1 0 0 1 1 1 1 HD domain HD_2 PF12917.7 CCF34649.1 - 4e-09 36.5 0.0 5.9e-09 35.9 0.0 1.2 1 0 0 1 1 1 1 HD containing hydrolase-like enzyme Peptidase_C6 PF00851.18 CCF34649.1 - 0.037 13.0 0.0 5.7 5.7 0.0 2.1 2 0 0 2 2 2 0 Helper component proteinase Abhydrolase_3 PF07859.13 CCF34651.1 - 2.9e-21 76.3 0.0 3.7e-21 76.0 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CCF34651.1 - 0.015 14.7 0.0 0.019 14.5 0.0 1.2 1 0 0 1 1 1 0 Prolyl oligopeptidase family HATPase_c PF02518.26 CCF34652.1 - 4.6e-20 72.2 0.0 1.2e-19 70.9 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CCF34652.1 - 1.2e-19 70.5 0.0 3.6e-19 69.0 0.0 1.9 1 1 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 CCF34652.1 - 6.6e-13 48.5 0.0 1.9e-12 47.0 0.0 1.8 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain GAF PF01590.26 CCF34652.1 - 1.2e-08 35.7 0.0 5.3e-07 30.3 0.0 3.3 3 1 0 3 3 3 1 GAF domain ATP_sub_h PF10775.9 CCF34653.1 - 0.61 10.1 7.6 16 5.5 0.1 3.2 1 1 2 3 3 3 0 ATP synthase complex subunit h DUF3328 PF11807.8 CCF34654.1 - 2.8e-51 174.4 0.7 3.2e-51 174.2 0.7 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) DUF87 PF01935.17 CCF34655.1 - 0.00081 19.6 0.0 0.39 10.8 0.0 2.4 2 0 0 2 2 2 2 Helicase HerA, central domain AAA_16 PF13191.6 CCF34655.1 - 0.0077 16.6 0.0 0.18 12.2 0.0 2.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 CCF34655.1 - 0.022 15.0 0.2 6.7 7.0 0.0 2.6 2 0 0 2 2 2 0 AAA domain Zot PF05707.12 CCF34655.1 - 0.022 14.4 0.0 0.053 13.2 0.0 1.7 2 0 0 2 2 2 0 Zonular occludens toxin (Zot) FtsK_SpoIIIE PF01580.18 CCF34655.1 - 0.041 13.2 0.0 0.088 12.1 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family Zeta_toxin PF06414.12 CCF34655.1 - 0.11 11.8 0.0 0.23 10.7 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA PF00004.29 CCF34655.1 - 0.16 12.4 0.1 0.65 10.4 0.0 1.9 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF1601 PF07671.11 CCF34655.1 - 0.46 10.4 1.5 8.7 6.3 0.3 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1601) Ribonuclease_T2 PF00445.18 CCF34656.1 - 1.7e-08 35.0 0.0 2.2e-08 34.6 0.0 1.2 1 0 0 1 1 1 1 Ribonuclease T2 family HAMP_N3 PF18575.1 CCF34656.1 - 0.046 13.3 0.0 0.068 12.8 0.0 1.2 1 0 0 1 1 1 0 HAMP N-terminal domain 3 PRCH PF03967.13 CCF34656.1 - 0.19 12.0 0.1 0.26 11.5 0.1 1.1 1 0 0 1 1 1 0 Photosynthetic reaction centre, H-chain N-terminal region Glyco_hydro_16 PF00722.21 CCF34657.1 - 4.5e-08 32.8 0.0 6.2e-08 32.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 SKN1 PF03935.15 CCF34657.1 - 4.2e-05 22.1 1.0 0.078 11.4 1.6 2.1 2 0 0 2 2 2 2 Beta-glucan synthesis-associated protein (SKN1) Peptidase_S8 PF00082.22 CCF34658.1 - 4e-40 138.0 3.8 7.1e-40 137.1 3.8 1.4 1 0 0 1 1 1 1 Subtilase family fn3_5 PF06280.12 CCF34658.1 - 9.8e-18 64.9 0.1 1.6e-17 64.2 0.1 1.3 1 0 0 1 1 1 1 Fn3-like domain Acetyltransf_2 PF00797.17 CCF34659.1 - 7.6e-26 91.4 0.0 8.8e-26 91.2 0.0 1.1 1 0 0 1 1 1 1 N-acetyltransferase Transglut_core PF01841.19 CCF34659.1 - 0.18 12.2 0.0 0.23 11.9 0.0 1.3 1 1 0 1 1 1 0 Transglutaminase-like superfamily HSP70 PF00012.20 CCF34660.1 - 1.1e-07 30.5 0.0 5.7e-06 24.8 0.0 2.2 2 0 0 2 2 2 2 Hsp70 protein Rz1 PF06085.11 CCF34660.1 - 0.16 11.8 0.6 0.73 9.6 0.3 2.2 2 0 0 2 2 2 0 Lipoprotein Rz1 precursor MFS_1 PF07690.16 CCF34661.1 - 2.3e-35 122.2 47.8 2.3e-35 122.2 47.8 2.3 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF34661.1 - 9.1e-07 28.1 9.4 9.1e-07 28.1 9.4 3.1 2 1 1 3 3 3 1 Sugar (and other) transporter UBM PF14377.6 CCF34661.1 - 0.03 13.8 0.4 0.066 12.7 0.4 1.5 1 0 0 1 1 1 0 Ubiquitin binding region Mito_carr PF00153.27 CCF34662.1 - 6.9e-72 237.5 0.1 1.4e-24 85.8 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_6 PF13405.6 CCF34662.1 - 5.6e-17 60.2 4.0 8.6e-08 31.5 0.4 5.3 5 0 0 5 5 5 3 EF-hand domain EF-hand_7 PF13499.6 CCF34662.1 - 2.1e-16 60.1 4.4 4.4e-09 36.7 0.4 3.2 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 CCF34662.1 - 2.3e-15 54.9 7.8 9.3e-08 31.1 0.5 5.1 5 0 0 5 5 5 3 EF hand EF-hand_5 PF13202.6 CCF34662.1 - 9.5e-10 37.5 5.1 3.3e-06 26.4 1.3 4.4 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 CCF34662.1 - 1.7e-07 30.9 2.0 0.27 11.1 0.1 5.1 5 0 0 5 5 5 3 EF-hand domain pair EF-hand_9 PF14658.6 CCF34662.1 - 0.0027 18.0 0.1 18 5.8 0.0 4.1 4 0 0 4 4 4 1 EF-hand domain RNB PF00773.19 CCF34662.1 - 0.23 10.8 0.0 0.75 9.1 0.0 1.7 2 0 0 2 2 2 0 RNB domain PQ-loop PF04193.14 CCF34663.1 - 1.7e-32 110.9 11.1 5.6e-16 58.1 2.8 2.5 2 0 0 2 2 2 2 PQ loop repeat MFS_1 PF07690.16 CCF34666.1 - 6.6e-17 61.5 28.0 3.7e-12 45.9 17.1 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF34666.1 - 0.16 10.8 28.3 0.046 12.6 3.1 3.8 3 1 1 4 4 4 0 Sugar (and other) transporter Pro-kuma_activ PF09286.11 CCF34668.1 - 2.3e-29 102.5 0.0 5.2e-29 101.4 0.0 1.6 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 CCF34668.1 - 2.5e-05 23.7 0.0 4.2e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Subtilase family Gly_transf_sug PF04488.15 CCF34670.1 - 3.4e-09 37.2 0.0 6e-09 36.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Caps_synth PF05704.12 CCF34670.1 - 2.1e-08 33.9 0.0 3e-08 33.4 0.0 1.2 1 0 0 1 1 1 1 Capsular polysaccharide synthesis protein Glyco_hydro_28 PF00295.17 CCF34671.1 - 4.1e-70 236.4 16.2 4.8e-70 236.2 16.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 adh_short PF00106.25 CCF34672.1 - 1.2e-26 93.4 0.0 1.5e-25 89.9 0.0 2.0 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF34672.1 - 2.7e-15 56.6 0.1 1.8e-14 53.9 0.1 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF34672.1 - 0.00018 21.5 0.0 0.00027 20.9 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF34672.1 - 0.0022 17.5 0.0 0.0052 16.3 0.0 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CCF34672.1 - 0.016 14.6 0.0 0.026 13.9 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase adh_short PF00106.25 CCF34673.1 - 3.3e-39 134.4 0.0 4.3e-39 134.0 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF34673.1 - 2.6e-26 92.6 0.0 3.2e-26 92.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF34673.1 - 3.6e-10 40.1 0.0 5.8e-10 39.4 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF34673.1 - 7.3e-06 25.6 0.0 1.5e-05 24.6 0.0 1.5 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family DUF1776 PF08643.10 CCF34673.1 - 0.0003 20.3 0.0 0.00041 19.8 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) ADH_zinc_N PF00107.26 CCF34673.1 - 0.002 18.1 0.2 0.0048 16.9 0.2 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase NmrA PF05368.13 CCF34673.1 - 0.011 15.3 0.0 0.06 12.9 0.1 1.9 2 0 0 2 2 2 0 NmrA-like family Death PF00531.22 CCF34673.1 - 0.05 13.8 0.0 0.14 12.3 0.0 1.7 2 0 0 2 2 2 0 Death domain Pkinase PF00069.25 CCF34676.1 - 6e-69 232.3 1.9 6e-68 229.1 1.9 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF34676.1 - 1.2e-53 182.0 0.1 2.4e-53 181.1 0.1 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 CCF34676.1 - 3.8e-24 84.8 0.7 8.6e-24 83.7 0.0 2.0 2 0 0 2 2 2 1 P21-Rho-binding domain PH_11 PF15413.6 CCF34676.1 - 4.5e-07 30.2 0.1 1.5e-06 28.6 0.0 2.0 2 0 0 2 2 2 1 Pleckstrin homology domain Kinase-like PF14531.6 CCF34676.1 - 4.9e-07 29.4 0.0 7.6e-07 28.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 CCF34676.1 - 6e-06 25.3 0.0 6e-06 25.3 0.0 2.0 2 1 0 2 2 1 1 Fungal protein kinase PH PF00169.29 CCF34676.1 - 0.002 18.6 0.0 0.0052 17.3 0.0 1.8 1 0 0 1 1 1 1 PH domain Seadorna_VP7 PF07387.11 CCF34676.1 - 0.028 13.5 0.0 0.048 12.7 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Haspin_kinase PF12330.8 CCF34676.1 - 0.042 12.8 0.0 0.075 12.0 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 CCF34676.1 - 0.049 13.5 0.2 0.049 13.5 0.2 2.5 2 1 1 3 3 3 0 Phosphotransferase enzyme family Kdo PF06293.14 CCF34676.1 - 0.11 11.9 0.0 0.22 10.9 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family N_BRCA1_IG PF16158.5 CCF34677.1 - 1.1e-34 119.2 0.0 5.5e-34 117.0 0.0 2.3 2 0 0 2 2 2 1 Ig-like domain from next to BRCA1 gene ZZ PF00569.17 CCF34677.1 - 2.9e-17 62.2 62.2 1.1e-05 25.1 8.6 4.4 4 0 0 4 4 4 4 Zinc finger, ZZ type C1_2 PF03107.16 CCF34677.1 - 0.0043 17.3 52.8 0.11 12.8 10.9 4.5 4 0 0 4 4 4 3 C1 domain COPIIcoated_ERV PF07970.12 CCF34678.1 - 5.6e-36 124.4 0.2 1.2e-35 123.4 0.2 1.4 1 1 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 CCF34678.1 - 1.8e-25 89.1 0.0 3.3e-25 88.3 0.0 1.4 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Colicin_V PF02674.16 CCF34678.1 - 0.13 12.3 0.1 0.31 11.0 0.0 1.6 2 0 0 2 2 2 0 Colicin V production protein Aconitase PF00330.20 CCF34679.1 - 1e-146 489.6 0.0 1.4e-146 489.2 0.0 1.2 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 CCF34679.1 - 1.3e-38 132.3 0.0 2.1e-38 131.6 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain DUF521 PF04412.13 CCF34679.1 - 0.015 14.1 0.0 0.024 13.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF521) Ldi PF18566.1 CCF34680.1 - 5e-100 335.1 0.4 5.9e-100 334.8 0.4 1.1 1 0 0 1 1 1 1 Linalool dehydratase/isomerase Cellulase PF00150.18 CCF34681.1 - 3.1e-19 69.5 3.0 5e-19 68.8 3.0 1.3 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_2_C PF02836.17 CCF34681.1 - 1.2e-05 24.6 0.0 2.5e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_42 PF02449.15 CCF34681.1 - 0.0012 18.2 0.1 0.0037 16.7 0.0 1.8 3 0 0 3 3 3 1 Beta-galactosidase Hfq PF17209.3 CCF34681.1 - 0.19 11.4 0.0 0.45 10.2 0.0 1.6 1 0 0 1 1 1 0 Hfq protein Solute_trans_a PF03619.16 CCF34682.1 - 1.9e-65 221.0 19.6 2.2e-65 220.8 19.6 1.0 1 0 0 1 1 1 1 Organic solute transporter Ostalpha FA_hydroxylase PF04116.13 CCF34684.1 - 1.9e-25 89.8 22.9 1.1e-24 87.2 20.6 2.1 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily DUF4727 PF15856.5 CCF34684.1 - 0.09 12.3 0.2 0.09 12.3 0.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4727) Kelch_5 PF13854.6 CCF34685.1 - 6.2e-10 38.8 3.1 1.7e-09 37.4 0.2 3.1 4 0 0 4 4 4 1 Kelch motif Gly-zipper_YMGG PF13441.6 CCF34685.1 - 0.013 15.2 0.2 0.034 13.9 0.2 1.6 1 0 0 1 1 1 0 YMGG-like Gly-zipper Kelch_3 PF13415.6 CCF34685.1 - 0.022 15.1 6.5 0.31 11.4 0.0 5.0 5 0 0 5 5 5 0 Galactose oxidase, central domain Gly-zipper_Omp PF13488.6 CCF34685.1 - 0.022 14.7 3.2 0.066 13.2 3.2 1.8 1 0 0 1 1 1 0 Glycine zipper DUF2207 PF09972.9 CCF34685.1 - 0.026 13.3 0.0 0.041 12.6 0.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Romo1 PF10247.9 CCF34685.1 - 0.051 13.9 0.3 0.19 12.1 0.3 1.9 1 0 0 1 1 1 0 Reactive mitochondrial oxygen species modulator 1 Kelch_4 PF13418.6 CCF34685.1 - 0.064 13.3 0.4 0.064 13.3 0.4 5.9 7 1 0 7 7 7 0 Galactose oxidase, central domain CD34_antigen PF06365.12 CCF34685.1 - 0.12 11.9 0.0 0.21 11.2 0.0 1.3 1 0 0 1 1 1 0 CD34/Podocalyxin family Kelch_1 PF01344.25 CCF34685.1 - 0.16 11.6 7.8 1.3 8.7 0.3 3.9 4 0 0 4 4 4 0 Kelch motif Adeno_E3_CR2 PF02439.15 CCF34685.1 - 0.24 11.2 0.9 0.44 10.4 0.9 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Kelch_6 PF13964.6 CCF34685.1 - 4.2 7.8 14.8 0.76 10.2 0.2 5.3 4 2 1 5 5 5 0 Kelch motif Asp PF00026.23 CCF34686.1 - 2e-50 172.0 0.0 2.5e-50 171.7 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCF34686.1 - 2.5e-09 37.6 0.1 3.9e-09 37.0 0.1 1.4 1 0 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 CCF34686.1 - 0.019 15.6 0.1 16 6.2 0.0 3.1 2 1 0 2 2 2 0 Aspartyl protease gag-asp_proteas PF13975.6 CCF34686.1 - 0.037 14.6 0.6 30 5.2 0.7 3.5 2 1 0 2 2 2 0 gag-polyprotein putative aspartyl protease Glyco_hydr_30_2 PF14587.6 CCF34687.1 - 2.1e-16 60.5 0.1 9.7e-16 58.3 0.1 1.9 1 1 0 1 1 1 1 O-Glycosyl hydrolase family 30 Glyco_hydro_59 PF02057.15 CCF34687.1 - 9e-10 38.3 0.0 1.4e-09 37.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 59 Glyco_hydro_30C PF17189.4 CCF34687.1 - 3.6e-09 36.7 5.9 1.5e-08 34.7 5.8 2.1 2 0 0 2 2 2 1 Glycosyl hydrolase family 30 beta sandwich domain Glyco_hydro_30 PF02055.16 CCF34687.1 - 1.8e-06 27.2 0.4 2.4e-06 26.8 0.4 1.4 1 1 0 1 1 1 1 Glycosyl hydrolase family 30 TIM-barrel domain APG17 PF04108.12 CCF34688.1 - 0.00021 20.6 7.6 0.00021 20.6 7.6 4.8 2 2 2 4 4 4 3 Autophagy protein Apg17 Spc7 PF08317.11 CCF34688.1 - 0.00022 20.2 16.1 0.00022 20.2 16.1 4.5 4 1 1 5 5 5 2 Spc7 kinetochore protein FOXP-CC PF16159.5 CCF34688.1 - 0.098 13.3 4.1 0.76 10.5 0.6 3.8 2 1 1 3 3 3 0 FOXP coiled-coil domain Shugoshin_N PF07558.11 CCF34688.1 - 0.24 11.3 10.5 15 5.6 0.2 4.3 3 1 1 4 4 4 0 Shugoshin N-terminal coiled-coil region BORCS7 PF16088.5 CCF34688.1 - 0.31 11.3 10.6 1.1 9.5 0.3 4.6 4 0 0 4 4 4 0 BLOC-1-related complex sub-unit 7 Titin_Ig-rpts PF06582.12 CCF34688.1 - 0.42 10.6 10.8 0.35 10.9 0.4 4.1 3 0 0 3 3 3 0 Titin repeat UCH PF00443.29 CCF34688.1 - 5.3 6.4 9.7 5.7 6.3 6.8 2.5 2 1 0 2 2 2 0 Ubiquitin carboxyl-terminal hydrolase CENP-H PF05837.12 CCF34689.1 - 2.4e-38 131.0 4.5 1.4e-36 125.3 1.9 2.1 2 0 0 2 2 2 2 Centromere protein H (CENP-H) TMF_TATA_bd PF12325.8 CCF34689.1 - 0.025 14.8 1.8 0.025 14.8 1.8 2.1 2 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding TMCO5 PF14992.6 CCF34689.1 - 0.049 13.2 0.2 0.096 12.3 0.2 1.4 1 0 0 1 1 1 0 TMCO5 family APG6_N PF17675.1 CCF34689.1 - 2.4 8.7 5.4 9.5 6.8 5.5 2.1 1 1 0 1 1 1 0 Apg6 coiled-coil region F-box-like_2 PF13013.6 CCF34691.1 - 0.061 13.3 0.0 0.094 12.7 0.0 1.3 1 0 0 1 1 1 0 F-box-like domain CBM_1 PF00734.18 CCF34692.1 - 1e-11 44.6 9.0 1e-11 44.6 9.0 2.5 2 0 0 2 2 2 1 Fungal cellulose binding domain Yeast-kill-tox PF09207.11 CCF34692.1 - 0.058 14.0 1.9 0.058 14.0 1.9 1.8 2 1 0 2 2 2 0 Yeast killer toxin Adap_comp_sub PF00928.21 CCF34693.1 - 2.2e-83 279.7 0.0 2.7e-83 279.4 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 CCF34693.1 - 8.3e-05 22.6 0.2 0.00015 21.7 0.2 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain muHD PF10291.9 CCF34693.1 - 0.05 13.0 0.1 0.1 12.0 0.1 1.5 1 0 0 1 1 1 0 Muniscin C-terminal mu homology domain RIBIOP_C PF04950.12 CCF34693.1 - 0.065 12.6 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal DUF647 PF04884.14 CCF34695.1 - 3.1e-26 92.5 0.2 3.5e-26 92.3 0.2 1.0 1 0 0 1 1 1 1 Vitamin B6 photo-protection and homoeostasis Rap1_C PF11626.8 CCF34697.1 - 5.5e-24 84.1 0.6 2.3e-23 82.1 0.2 2.2 2 0 0 2 2 2 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain Myb_DNA-bind_2 PF08914.11 CCF34697.1 - 1e-14 54.4 4.7 8.1e-11 41.9 0.1 3.2 3 0 0 3 3 3 2 Rap1 Myb domain BRCT_2 PF16589.5 CCF34697.1 - 1.6e-12 47.6 0.0 3.2e-12 46.7 0.0 1.5 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain ARID PF01388.21 CCF34697.1 - 3.3e-07 30.9 0.0 7.1e-07 29.8 0.0 1.6 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain Rap1-DNA-bind PF09197.10 CCF34697.1 - 1.2e-06 29.1 1.2 0.0033 18.0 0.0 2.9 2 0 0 2 2 2 2 Rap1, DNA-binding DHHC PF01529.20 CCF34698.1 - 5.2e-32 110.8 1.2 5.2e-32 110.8 1.2 2.2 3 0 0 3 3 3 1 DHHC palmitoyltransferase DUF2231 PF09990.9 CCF34698.1 - 8.2 6.9 8.4 2.6 8.5 0.4 2.6 2 0 0 2 2 2 0 Predicted membrane protein (DUF2231) zf-AD PF07776.15 CCF34698.1 - 8.7 6.7 8.3 55 4.1 8.9 1.8 1 1 1 2 2 2 0 Zinc-finger associated domain (zf-AD) AHSA1 PF08327.11 CCF34699.1 - 3.3e-19 69.4 0.4 3.7e-19 69.2 0.4 1.0 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Sugar_tr PF00083.24 CCF34700.1 - 1.7e-105 353.5 21.6 5.1e-103 345.3 21.6 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF34700.1 - 9.9e-21 74.0 32.1 9.9e-21 74.0 32.1 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF4410 PF14366.6 CCF34700.1 - 0.011 15.7 0.0 0.023 14.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4410) DUF1269 PF06897.12 CCF34700.1 - 8.5 6.7 6.6 11 6.3 0.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1269) ADH_zinc_N PF00107.26 CCF34701.1 - 4.3e-12 46.1 0.1 7.6e-12 45.3 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCF34701.1 - 1.2e-07 31.5 0.1 1.5e-06 28.0 0.0 2.3 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain PS-DH PF14765.6 CCF34702.1 - 6e-63 212.8 0.1 1.5e-62 211.6 0.1 1.7 2 0 0 2 2 2 1 Polyketide synthase dehydratase ketoacyl-synt PF00109.26 CCF34702.1 - 1.6e-56 191.7 0.0 4.5e-56 190.2 0.0 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 CCF34702.1 - 1.2e-49 169.5 0.0 2e-49 168.8 0.0 1.4 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 CCF34702.1 - 1.1e-32 112.6 0.0 3.9e-32 110.7 0.0 2.0 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 CCF34702.1 - 6e-24 84.7 0.0 1.3e-23 83.6 0.0 1.6 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Thiolase_N PF00108.23 CCF34702.1 - 0.0026 17.2 0.7 0.0074 15.7 0.7 1.7 1 0 0 1 1 1 1 Thiolase, N-terminal domain ACP_syn_III PF08545.10 CCF34702.1 - 0.078 12.8 1.6 0.21 11.5 1.6 1.6 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III UPRTase PF14681.6 CCF34703.1 - 1.1e-73 247.1 0.0 1.3e-73 246.9 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 CCF34703.1 - 8.3e-05 22.2 0.0 0.00016 21.3 0.0 1.4 1 1 0 1 1 1 1 Phosphoribosyl transferase domain P5CR_dimer PF14748.6 CCF34703.1 - 0.047 13.9 0.0 0.1 12.9 0.0 1.5 1 0 0 1 1 1 0 Pyrroline-5-carboxylate reductase dimerisation NAD_binding_10 PF13460.6 CCF34703.1 - 0.084 12.8 0.1 0.13 12.2 0.1 1.2 1 0 0 1 1 1 0 NAD(P)H-binding TMP-TENI PF02581.17 CCF34703.1 - 0.12 11.7 0.7 0.86 8.9 0.2 2.2 2 1 0 2 2 2 0 Thiamine monophosphate synthase DNA_ligase_A_M PF01068.21 CCF34704.1 - 1.3e-43 149.0 0.0 3e-43 147.9 0.0 1.6 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 CCF34704.1 - 3e-41 141.6 0.0 5.8e-41 140.7 0.0 1.5 1 0 0 1 1 1 1 DNA ligase N terminus RNA_ligase PF09414.10 CCF34704.1 - 1.1e-16 61.5 0.0 2.5e-16 60.4 0.0 1.6 1 0 0 1 1 1 1 RNA ligase BRCT_2 PF16589.5 CCF34704.1 - 2.9e-15 56.4 0.0 1.5e-09 38.1 0.0 2.4 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain DNA_ligase_A_C PF04679.15 CCF34704.1 - 3.7e-15 56.3 0.4 1.6e-14 54.3 0.0 2.4 2 0 0 2 2 2 1 ATP dependent DNA ligase C terminal region BRCT PF00533.26 CCF34704.1 - 8.8e-11 42.0 0.0 8.9e-08 32.4 0.0 2.6 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain DNA_ligase_IV PF11411.8 CCF34704.1 - 0.00046 20.2 0.0 0.00087 19.4 0.0 1.5 1 0 0 1 1 1 1 DNA ligase IV RTT107_BRCT_5 PF16770.5 CCF34704.1 - 0.023 14.5 0.0 4.4 7.3 0.0 2.5 2 0 0 2 2 2 0 Regulator of Ty1 transposition protein 107 BRCT domain VSP PF03302.13 CCF34705.1 - 0.044 12.6 0.2 0.057 12.3 0.2 1.2 1 0 0 1 1 1 0 Giardia variant-specific surface protein DUF5460 PF17544.2 CCF34705.1 - 0.054 12.5 0.0 0.063 12.3 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5460) Aa_trans PF01490.18 CCF34706.1 - 6e-17 61.5 3.0 7.1e-17 61.2 3.0 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Clc-like PF07062.12 CCF34706.1 - 0.1 12.1 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 Clc-like KH_8 PF17903.1 CCF34707.1 - 2e-30 104.7 0.0 4.7e-30 103.5 0.0 1.7 1 0 0 1 1 1 1 Krr1 KH1 domain KH_1 PF00013.29 CCF34707.1 - 0.0035 17.1 0.0 0.0094 15.8 0.0 1.8 1 0 0 1 1 1 1 KH domain DUF2381 PF09544.10 CCF34707.1 - 0.012 15.2 0.8 0.025 14.1 0.5 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2381) ADH_zinc_N PF00107.26 CCF34709.1 - 6.7e-22 77.9 0.2 1e-21 77.3 0.2 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCF34709.1 - 7.6e-10 40.0 0.1 2.5e-09 38.3 0.1 1.9 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCF34709.1 - 0.00052 19.9 0.0 0.0011 18.8 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain adh_short PF00106.25 CCF34709.1 - 0.061 12.8 0.3 0.11 11.9 0.3 1.5 1 1 0 1 1 1 0 short chain dehydrogenase Rhodanese PF00581.20 CCF34711.1 - 3.9e-07 30.5 0.0 9.9e-07 29.2 0.0 1.7 1 0 0 1 1 1 1 Rhodanese-like domain Homeodomain PF00046.29 CCF34711.1 - 1.3e-06 28.1 0.2 3.7e-06 26.7 0.2 1.7 1 0 0 1 1 1 1 Homeodomain PIG-X PF08320.12 CCF34712.1 - 6.4e-68 228.8 0.0 9.2e-68 228.3 0.0 1.2 1 0 0 1 1 1 1 PIG-X / PBN1 TPR_1 PF00515.28 CCF34714.1 - 2.8e-17 61.7 4.9 9.3e-05 22.1 0.0 5.5 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 CCF34714.1 - 6.1e-15 54.1 3.4 0.0091 16.0 0.0 5.9 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_11 PF13414.6 CCF34714.1 - 4.7e-13 48.6 5.7 0.0017 18.0 0.0 5.3 3 1 2 5 5 5 4 TPR repeat TPR_8 PF13181.6 CCF34714.1 - 7.6e-11 41.3 5.7 0.0021 18.1 0.0 5.8 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_10 PF13374.6 CCF34714.1 - 1.5e-10 40.6 3.7 0.0081 16.0 0.1 5.2 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.6 CCF34714.1 - 6.9e-09 35.5 4.5 0.0027 18.0 0.0 5.1 6 1 0 6 6 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 CCF34714.1 - 9.7e-09 35.7 0.6 0.012 16.3 0.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 CCF34714.1 - 3.2e-08 33.7 6.5 0.059 14.2 0.0 5.0 4 1 1 5 5 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 CCF34714.1 - 2.5e-07 30.2 0.3 0.011 15.7 0.0 3.7 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 CCF34714.1 - 3.2e-06 27.3 6.9 0.00049 20.3 0.3 4.8 4 1 1 5 5 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 CCF34714.1 - 0.00012 22.5 2.6 0.002 18.6 0.3 3.1 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_9 PF13371.6 CCF34714.1 - 0.0061 16.7 0.1 0.16 12.1 0.0 3.1 2 1 0 2 2 2 1 Tetratricopeptide repeat Glyco_transf_41 PF13844.6 CCF34714.1 - 0.011 14.2 0.1 0.014 13.8 0.1 1.1 1 0 0 1 1 1 0 Glycosyl transferase family 41 BTAD PF03704.17 CCF34714.1 - 0.074 13.5 0.5 0.33 11.4 0.0 2.2 2 0 0 2 2 2 0 Bacterial transcriptional activator domain Endonuc-FokI_C PF09254.11 CCF34714.1 - 0.22 10.8 0.0 0.47 9.7 0.0 1.4 1 0 0 1 1 1 0 Restriction endonuclease FokI, C terminal TPR_6 PF13174.6 CCF34714.1 - 0.42 11.3 6.2 37 5.2 0.0 4.7 5 0 0 5 5 4 0 Tetratricopeptide repeat Ribosomal_L11_N PF03946.14 CCF34715.1 - 7.1e-22 77.0 0.0 1.2e-21 76.3 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 CCF34715.1 - 2.6e-17 63.1 0.2 4.2e-17 62.4 0.2 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Colicin PF01024.19 CCF34715.1 - 0.092 12.6 0.4 0.35 10.7 0.0 1.9 2 0 0 2 2 2 0 Colicin pore forming domain Edc3_linker PF16598.5 CCF34716.1 - 3 8.6 14.8 0.51 11.0 5.3 3.2 2 1 1 3 3 3 0 Linker region of enhancer of mRNA-decapping protein 3 Mcp5_PH PF12814.7 CCF34717.1 - 2e-44 150.6 0.0 3.5e-44 149.8 0.0 1.4 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology PH PF00169.29 CCF34717.1 - 4.8e-05 23.8 0.0 0.00014 22.3 0.0 1.8 1 0 0 1 1 1 1 PH domain zf-C3HC4_3 PF13920.6 CCF34718.1 - 1.4e-07 31.3 5.2 2.4e-07 30.5 5.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-CCCH PF00642.24 CCF34718.1 - 2.5e-07 30.4 2.3 4.9e-07 29.5 2.3 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-RING_UBOX PF13445.6 CCF34718.1 - 3.7e-07 30.0 6.9 7.5e-07 29.1 6.9 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 CCF34718.1 - 1e-06 28.5 9.8 1.8e-06 27.7 9.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CCF34718.1 - 2.8e-06 27.0 8.4 5.1e-06 26.2 8.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CCF34718.1 - 3e-06 27.1 7.8 5.2e-06 26.3 7.8 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_10 PF16685.5 CCF34718.1 - 5.7e-05 23.2 3.0 0.00014 21.9 3.0 1.6 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf_CCCH_4 PF18345.1 CCF34718.1 - 7.7e-05 22.6 5.8 0.00015 21.7 5.8 1.5 1 0 0 1 1 1 1 Zinc finger domain zf-RING_2 PF13639.6 CCF34718.1 - 0.00011 22.5 7.0 0.00021 21.5 7.0 1.5 1 0 0 1 1 1 1 Ring finger domain zf-CCCH_4 PF18044.1 CCF34718.1 - 0.00021 21.0 2.6 0.00042 20.1 2.6 1.5 1 0 0 1 1 1 1 CCCH-type zinc finger Prok-RING_4 PF14447.6 CCF34718.1 - 0.0047 16.8 5.4 0.0088 15.9 5.4 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 CCF34718.1 - 0.078 13.2 8.4 0.18 12.0 8.4 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Harakiri PF15196.6 CCF34718.1 - 0.11 12.9 1.2 0.29 11.6 1.2 1.7 1 0 0 1 1 1 0 Activator of apoptosis harakiri zf-CCCH_2 PF14608.6 CCF34718.1 - 0.16 12.5 3.2 0.31 11.6 3.2 1.5 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger zf-rbx1 PF12678.7 CCF34718.1 - 0.5 10.7 3.6 1 9.7 3.6 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger domain SPATA3 PF15662.5 CCF34718.1 - 1 10.0 7.5 2.3 8.8 7.5 1.5 1 0 0 1 1 1 0 Spermatogenesis-associated protein 3 family MARVEL PF01284.23 CCF34719.1 - 6.6e-07 29.5 14.7 1.1e-06 28.7 14.7 1.3 1 1 0 1 1 1 1 Membrane-associating domain DUF2070 PF09843.9 CCF34719.1 - 0.14 10.4 11.6 0.17 10.1 11.6 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) MT0933_antitox PF14013.6 CCF34720.1 - 0.075 13.4 5.3 0.091 13.1 3.1 2.1 1 1 1 2 2 2 0 MT0933-like antitoxin protein Cnn_1N PF07989.11 CCF34722.1 - 1.1e-19 70.4 4.7 1.9e-19 69.6 4.7 1.4 1 0 0 1 1 1 1 Centrosomin N-terminal motif 1 Hydrolase_6 PF13344.6 CCF34723.1 - 4.6e-25 87.7 0.0 8.8e-25 86.8 0.0 1.5 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CCF34723.1 - 7.3e-18 64.4 0.0 2e-17 63.0 0.0 1.8 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 CCF34723.1 - 5.2e-05 23.6 0.1 0.5 10.6 0.0 4.0 2 1 2 4 4 4 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 CCF34723.1 - 0.089 12.9 0.0 37 4.3 0.0 3.1 3 1 0 3 3 3 0 Haloacid dehalogenase-like hydrolase SCO1-SenC PF02630.14 CCF34724.1 - 1.3e-33 115.8 0.0 9.1e-31 106.6 0.0 2.2 1 1 0 1 1 1 1 SCO1/SenC PHD PF00628.29 CCF34725.1 - 5.7e-12 45.3 6.1 1.6e-11 43.9 6.1 1.8 1 0 0 1 1 1 1 PHD-finger PHD_4 PF16866.5 CCF34725.1 - 0.1 12.7 5.0 0.26 11.4 5.0 1.7 1 0 0 1 1 1 0 PHD-finger PTN_MK_N PF05196.13 CCF34725.1 - 0.41 10.9 6.1 11 6.3 1.3 2.7 2 0 0 2 2 2 0 PTN/MK heparin-binding protein family, N-terminal domain zf-4CXXC_R1 PF10497.9 CCF34725.1 - 2.1 8.6 7.1 8.2 6.7 2.7 2.4 2 0 0 2 2 2 0 Zinc-finger domain of monoamine-oxidase A repressor R1 zf-RING_2 PF13639.6 CCF34725.1 - 3.8 7.9 6.6 8.6 6.8 6.6 1.6 1 0 0 1 1 1 0 Ring finger domain Egh16-like PF11327.8 CCF34727.1 - 4.5e-66 222.8 12.7 1.5e-65 221.1 12.7 1.7 1 1 0 1 1 1 1 Egh16-like virulence factor PI-PLC-C1 PF16670.5 CCF34728.1 - 0.0066 15.6 0.4 0.84 8.6 0.0 2.9 1 1 1 3 3 3 3 Phosphoinositide phospholipase C, Ca2+-dependent ANAPC8 PF04049.13 CCF34729.1 - 1.1e-43 148.7 0.9 1.9e-43 147.9 0.1 1.9 2 0 0 2 2 2 1 Anaphase promoting complex subunit 8 / Cdc23 TPR_8 PF13181.6 CCF34729.1 - 6.6e-23 79.0 8.4 8.9e-05 22.4 0.0 7.4 7 1 0 7 7 6 4 Tetratricopeptide repeat TPR_1 PF00515.28 CCF34729.1 - 1.2e-21 75.6 5.2 0.00082 19.1 0.0 8.2 8 1 1 9 9 8 4 Tetratricopeptide repeat TPR_2 PF07719.17 CCF34729.1 - 4e-16 57.8 18.3 0.093 12.9 0.0 9.2 9 1 1 10 10 9 4 Tetratricopeptide repeat TPR_14 PF13428.6 CCF34729.1 - 4e-09 36.5 19.3 0.0065 17.2 0.2 8.4 8 2 1 9 9 7 2 Tetratricopeptide repeat TPR_16 PF13432.6 CCF34729.1 - 2.3e-07 31.4 9.0 2.1e-06 28.3 0.1 6.0 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_11 PF13414.6 CCF34729.1 - 2.6e-07 30.2 0.7 3.3e-06 26.7 0.2 3.1 3 0 0 3 3 3 1 TPR repeat TPR_12 PF13424.6 CCF34729.1 - 5.2e-07 29.9 17.4 1.4 9.3 0.1 7.2 6 1 1 7 7 7 3 Tetratricopeptide repeat ANAPC3 PF12895.7 CCF34729.1 - 1.7e-05 25.0 7.3 0.12 12.7 0.4 5.7 4 1 2 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 CCF34729.1 - 9.4e-05 22.8 12.1 0.38 11.3 0.1 6.8 7 1 1 8 8 7 2 Tetratricopeptide repeat TPR_7 PF13176.6 CCF34729.1 - 0.0002 21.2 8.8 0.58 10.3 0.0 5.9 6 0 0 6 6 6 1 Tetratricopeptide repeat DUF3856 PF12968.7 CCF34729.1 - 0.00024 21.2 1.1 0.055 13.5 0.1 3.3 1 1 0 2 2 2 1 Domain of Unknown Function (DUF3856) TPR_17 PF13431.6 CCF34729.1 - 0.00081 19.6 0.7 8.8 7.0 0.0 5.1 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 CCF34729.1 - 0.0018 18.8 14.7 1.8 9.4 0.2 7.5 8 1 1 9 9 8 1 Tetratricopeptide repeat TPR_9 PF13371.6 CCF34729.1 - 0.0058 16.8 15.4 1 9.5 0.1 5.3 6 0 0 6 6 6 2 Tetratricopeptide repeat Sel1 PF08238.12 CCF34729.1 - 0.082 13.6 4.2 92 3.9 0.0 5.5 5 0 0 5 5 5 0 Sel1 repeat DUF842 PF05811.13 CCF34729.1 - 0.21 11.3 0.0 0.39 10.4 0.0 1.4 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF842) polyprenyl_synt PF00348.17 CCF34730.1 - 1.1e-89 299.9 0.0 1.4e-89 299.5 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase Peptidase_M20 PF01546.28 CCF34732.1 - 5.7e-33 114.4 0.1 8.1e-33 113.9 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 CCF34732.1 - 0.0014 18.5 0.0 0.0043 16.9 0.0 1.8 1 1 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 CCF34732.1 - 0.004 16.9 0.0 0.011 15.4 0.0 1.7 2 0 0 2 2 2 1 Peptidase family M28 DUF2834 PF11196.8 CCF34734.1 - 0.0045 17.3 0.5 0.0045 17.3 0.5 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF2834) MARVEL PF01284.23 CCF34735.1 - 4.5e-16 59.2 1.9 5.4e-16 58.9 1.9 1.1 1 0 0 1 1 1 1 Membrane-associating domain Phage_holin_3_6 PF07332.11 CCF34735.1 - 0.57 10.2 8.8 0.11 12.6 2.7 2.1 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Tim17 PF02466.19 CCF34736.1 - 6e-25 87.8 4.0 9.2e-25 87.2 4.0 1.3 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Endonuclease_5 PF04493.14 CCF34736.1 - 0.051 13.3 0.0 0.069 12.8 0.0 1.1 1 0 0 1 1 1 0 Endonuclease V Aspzincin_M35 PF14521.6 CCF34737.1 - 9.4e-05 23.0 0.0 0.00012 22.7 0.0 1.1 1 0 0 1 1 1 1 Lysine-specific metallo-endopeptidase CRAL_TRIO PF00650.20 CCF34738.1 - 3e-37 127.8 0.0 7.3e-37 126.5 0.0 1.6 2 0 0 2 2 2 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 CCF34738.1 - 0.0008 19.6 1.0 0.0026 17.9 0.1 2.2 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 CCF34738.1 - 0.0031 17.7 0.0 0.0065 16.6 0.0 1.5 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain DUF1769 PF08588.10 CCF34738.1 - 0.047 13.9 0.0 0.1 12.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1769) Erf4 PF10256.9 CCF34739.1 - 0.0089 16.1 0.0 0.16 12.0 0.0 2.6 2 1 0 2 2 2 1 Golgin subfamily A member 7/ERF4 family Zip PF02535.22 CCF34739.1 - 3.2 6.9 6.3 1.9 7.6 0.0 2.2 2 0 0 2 2 2 0 ZIP Zinc transporter GAT PF03127.14 CCF34740.1 - 1.1e-19 70.5 1.9 1.9e-18 66.5 0.4 2.5 2 1 0 2 2 2 1 GAT domain VHS PF00790.19 CCF34740.1 - 0.0002 21.2 0.0 0.00056 19.8 0.0 1.7 2 0 0 2 2 2 1 VHS domain DUF3110 PF11360.8 CCF34740.1 - 0.1 12.8 0.1 26 5.1 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3110) UBX PF00789.20 CCF34741.1 - 5.7e-07 29.7 0.0 1.1e-06 28.7 0.0 1.5 1 0 0 1 1 1 1 UBX domain SUB1_ProdP9 PF18213.1 CCF34741.1 - 0.0027 17.5 0.0 0.0071 16.2 0.0 1.6 1 0 0 1 1 1 1 SUB1 protease Prodomain ProdP9 DUF1682 PF07946.14 CCF34741.1 - 0.023 13.9 11.8 0.27 10.4 12.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1682) DUF612 PF04747.12 CCF34741.1 - 0.067 12.3 12.8 0.096 11.8 12.8 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF612 Presenilin PF01080.17 CCF34741.1 - 8.1 5.1 5.4 12 4.6 5.4 1.2 1 0 0 1 1 1 0 Presenilin HSP20 PF00011.21 CCF34742.1 - 9e-13 48.3 0.0 7.2e-12 45.3 0.0 2.0 2 0 0 2 2 2 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 CCF34742.1 - 0.011 15.3 0.0 0.021 14.4 0.0 1.4 1 0 0 1 1 1 0 HSP20-like domain found in ArsA Rad51 PF08423.11 CCF34743.1 - 1.8e-127 423.9 0.0 2.3e-127 423.6 0.0 1.1 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.6 CCF34743.1 - 1.7e-08 34.3 0.0 2.6e-08 33.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain RecA PF00154.21 CCF34743.1 - 2.1e-08 34.0 0.0 2.9e-08 33.5 0.0 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein HHH_5 PF14520.6 CCF34743.1 - 1.2e-06 29.0 0.6 5.3e-06 26.9 0.1 2.2 2 0 0 2 2 2 1 Helix-hairpin-helix domain ATPase PF06745.13 CCF34743.1 - 9.9e-06 25.1 0.0 2.2e-05 24.0 0.0 1.6 1 1 0 1 1 1 1 KaiC DnaB_C PF03796.15 CCF34743.1 - 0.033 13.5 0.1 0.16 11.3 0.0 1.9 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain ssDNA_TraI_N PF18272.1 CCF34743.1 - 0.11 12.5 0.1 0.59 10.2 0.1 2.1 2 0 0 2 2 2 0 single-stranded DNA binding TraI N-terminal subdomain AAA_24 PF13479.6 CCF34743.1 - 0.13 12.0 0.0 0.26 11.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain PAXNEB PF05625.11 CCF34743.1 - 0.19 10.8 0.2 0.84 8.7 0.1 1.8 2 0 0 2 2 2 0 PAXNEB protein Nup160 PF11715.8 CCF34744.1 - 2.6e-148 495.0 0.3 3.3e-148 494.7 0.3 1.1 1 0 0 1 1 1 1 Nucleoporin Nup120/160 TPR_2 PF07719.17 CCF34744.1 - 0.17 12.1 0.1 0.5 10.6 0.1 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat LRR_4 PF12799.7 CCF34745.1 - 2 8.9 16.6 13 6.3 0.1 6.9 7 2 1 8 8 8 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCF34745.1 - 4.6 7.1 10.3 2.2 8.1 0.2 5.1 6 0 0 6 6 6 0 Leucine rich repeat Rad9 PF04139.13 CCF34746.1 - 4.2e-48 164.0 0.0 5.1e-48 163.7 0.0 1.1 1 0 0 1 1 1 1 Rad9 Hus1 PF04005.12 CCF34746.1 - 0.034 13.3 0.0 0.051 12.7 0.0 1.2 1 0 0 1 1 1 0 Hus1-like protein RCC1 PF00415.18 CCF34747.1 - 4.3e-34 116.9 8.9 5.4e-10 39.7 0.0 6.7 6 0 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 CCF34747.1 - 3.2e-17 61.8 21.2 0.0002 21.1 0.2 7.0 7 1 0 7 7 7 4 Regulator of chromosome condensation (RCC1) repeat PDH PF02153.17 CCF34748.1 - 4.2e-14 52.2 0.0 6.3e-14 51.6 0.0 1.2 1 0 0 1 1 1 1 Prephenate dehydrogenase F420_oxidored PF03807.17 CCF34748.1 - 2.7e-07 31.1 0.0 5.8e-07 30.0 0.0 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 CCF34748.1 - 3.3e-07 30.6 0.0 6.4e-07 29.7 0.0 1.5 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.19 CCF34748.1 - 3.6e-05 23.2 0.0 6.5e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 CCF34748.1 - 0.0048 17.0 0.0 0.011 15.7 0.0 1.6 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase ApbA PF02558.16 CCF34748.1 - 0.0073 16.0 0.0 0.015 15.0 0.0 1.5 1 1 0 1 1 1 1 Ketopantoate reductase PanE/ApbA TrkA_N PF02254.18 CCF34748.1 - 0.0098 16.1 0.1 0.028 14.7 0.0 1.8 2 0 0 2 2 2 1 TrkA-N domain 3HCDH_N PF02737.18 CCF34748.1 - 0.064 13.1 0.1 0.12 12.3 0.1 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Mpv17_PMP22 PF04117.12 CCF34750.1 - 6.8e-10 39.0 2.5 6.8e-10 39.0 2.5 2.2 3 0 0 3 3 3 1 Mpv17 / PMP22 family EAP30 PF04157.16 CCF34751.1 - 1.3e-76 257.0 0.2 1.5e-76 256.8 0.2 1.0 1 0 0 1 1 1 1 EAP30/Vps36 family Ribosomal_S9 PF00380.19 CCF34752.1 - 0.0011 19.4 0.0 0.0013 19.2 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S9/S16 DUF3517 PF12030.8 CCF34753.1 - 3.6e-100 335.1 2.1 5.1e-100 334.7 2.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3517) UCH PF00443.29 CCF34753.1 - 4.6e-41 141.0 0.1 9.8e-41 139.9 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CCF34753.1 - 1.5e-20 74.0 0.1 4.4e-20 72.5 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 CCF34753.1 - 0.015 14.8 0.2 0.038 13.5 0.2 1.6 1 0 0 1 1 1 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase Pox_A3L PF05288.11 CCF34753.1 - 0.025 14.5 1.9 0.048 13.6 0.0 2.5 3 0 0 3 3 3 0 Poxvirus A3L Protein MFS_1 PF07690.16 CCF34756.1 - 5.8e-17 61.7 41.1 5.8e-17 61.7 41.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF34756.1 - 2.7e-05 23.2 9.4 2.7e-05 23.2 9.4 3.0 2 1 1 3 3 3 1 Sugar (and other) transporter adh_short PF00106.25 CCF34758.1 - 4.4e-34 117.7 0.7 5.8e-34 117.3 0.7 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF34758.1 - 1.1e-25 90.6 0.8 6.8e-24 84.7 0.8 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF34758.1 - 4.2e-09 36.6 0.1 7.9e-09 35.7 0.1 1.4 2 0 0 2 2 2 1 KR domain PA PF02225.22 CCF34758.1 - 0.043 13.8 0.2 0.091 12.8 0.2 1.5 1 0 0 1 1 1 0 PA domain ParA PF10609.9 CCF34761.1 - 2.9e-90 302.0 0.0 4e-90 301.6 0.0 1.2 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 CCF34761.1 - 1.1e-11 44.8 0.0 1.6e-10 41.1 0.0 2.2 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MipZ PF09140.11 CCF34761.1 - 2.1e-07 30.5 0.0 4.6e-06 26.1 0.0 2.1 2 0 0 2 2 2 1 ATPase MipZ AAA_31 PF13614.6 CCF34761.1 - 3.1e-06 27.2 0.1 0.00026 21.0 0.1 2.2 2 0 0 2 2 2 1 AAA domain ArsA_ATPase PF02374.15 CCF34761.1 - 0.00014 21.2 1.4 0.00015 21.1 0.4 1.5 2 0 0 2 2 2 1 Anion-transporting ATPase AAA_25 PF13481.6 CCF34761.1 - 0.00082 19.0 0.1 0.0016 18.1 0.1 1.4 1 0 0 1 1 1 1 AAA domain MeaB PF03308.16 CCF34761.1 - 0.001 18.1 0.5 0.0018 17.3 0.5 1.3 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB CBP_BcsQ PF06564.12 CCF34761.1 - 0.014 14.8 0.4 0.042 13.3 0.4 1.8 1 1 0 1 1 1 0 Cellulose biosynthesis protein BcsQ Zeta_toxin PF06414.12 CCF34761.1 - 0.04 13.2 0.0 0.068 12.4 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin AAA_26 PF13500.6 CCF34761.1 - 0.052 13.4 0.6 3 7.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain APS_kinase PF01583.20 CCF34761.1 - 0.062 13.2 0.1 0.096 12.6 0.1 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase RsgA_GTPase PF03193.16 CCF34761.1 - 0.15 12.0 1.3 0.36 10.7 1.3 1.6 1 0 0 1 1 1 0 RsgA GTPase AAA_16 PF13191.6 CCF34761.1 - 0.17 12.2 0.3 0.46 10.8 0.3 1.6 2 0 0 2 2 2 0 AAA ATPase domain adh_short_C2 PF13561.6 CCF34762.1 - 2.6e-54 184.3 0.7 3.7e-54 183.7 0.7 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF34762.1 - 3.5e-46 157.1 2.8 4.3e-46 156.8 2.8 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF34762.1 - 9.4e-15 55.0 0.5 1.2e-14 54.6 0.5 1.1 1 0 0 1 1 1 1 KR domain ADH_zinc_N PF00107.26 CCF34762.1 - 0.01 15.8 1.0 1.3 9.0 1.0 2.3 1 1 0 1 1 1 0 Zinc-binding dehydrogenase THF_DHG_CYH_C PF02882.19 CCF34762.1 - 0.017 14.4 0.1 0.029 13.7 0.1 1.4 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DUF1372 PF07116.11 CCF34762.1 - 0.12 12.6 0.0 0.3 11.3 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1372) DUF3606 PF12244.8 CCF34762.1 - 0.32 10.9 1.1 0.59 10.1 1.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3606) LysM PF01476.20 CCF34763.1 - 7.6e-07 29.1 0.3 1.1e-06 28.6 0.3 1.3 1 0 0 1 1 1 1 LysM domain PepSY_2 PF13670.6 CCF34763.1 - 0.19 11.8 0.4 0.29 11.2 0.4 1.4 1 1 0 1 1 1 0 Peptidase propeptide and YPEB domain Pec_lyase_C PF00544.19 CCF34764.1 - 8.9e-30 103.8 3.4 8.9e-30 103.8 3.4 1.5 2 0 0 2 2 2 1 Pectate lyase V-SNARE_C PF12352.8 CCF34765.1 - 1.7e-14 53.8 0.3 1.7e-14 53.8 0.3 2.8 4 0 0 4 4 3 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 CCF34765.1 - 0.00013 21.8 0.1 0.0015 18.4 0.0 2.5 2 1 1 3 3 3 1 Sec20 CK2S PF15011.6 CCF34765.1 - 0.0022 17.9 0.8 0.0041 17.0 0.5 1.6 2 0 0 2 2 2 1 Casein Kinase 2 substrate KxDL PF10241.9 CCF34765.1 - 0.0065 16.7 4.5 0.91 9.8 0.9 3.1 3 0 0 3 3 3 1 Uncharacterized conserved protein Sigma70_r4 PF04545.16 CCF34765.1 - 0.026 14.1 1.3 0.034 13.6 0.1 1.8 2 0 0 2 2 2 0 Sigma-70, region 4 RmuC PF02646.16 CCF34765.1 - 0.028 13.5 0.6 0.043 12.9 0.2 1.6 2 0 0 2 2 2 0 RmuC family Spc7 PF08317.11 CCF34765.1 - 0.034 13.0 6.8 0.049 12.5 5.4 1.8 2 0 0 2 2 2 0 Spc7 kinetochore protein PilJ PF13675.6 CCF34765.1 - 0.048 13.7 1.3 0.11 12.5 1.3 1.7 1 0 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term DUF4407 PF14362.6 CCF34765.1 - 0.11 11.9 2.9 0.23 10.8 2.9 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) TPR_MLP1_2 PF07926.12 CCF34765.1 - 0.27 11.3 8.9 0.65 10.1 4.6 2.8 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein Lectin_N PF03954.14 CCF34765.1 - 0.28 10.9 3.2 0.17 11.7 1.0 1.7 2 1 0 2 2 2 0 Hepatic lectin, N-terminal domain F_actin_bind PF08919.10 CCF34765.1 - 0.31 11.2 3.0 0.77 9.9 3.0 1.7 1 1 0 1 1 1 0 F-actin binding DUF1664 PF07889.12 CCF34765.1 - 0.38 10.8 2.4 2.7 8.0 0.7 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) RTX_C PF08339.10 CCF34765.1 - 0.41 10.7 5.6 0.6 10.2 1.6 2.5 1 1 1 2 2 2 0 RTX C-terminal domain Syntaxin-6_N PF09177.11 CCF34765.1 - 0.47 11.0 3.7 0.83 10.2 2.3 2.1 2 1 1 3 3 3 0 Syntaxin 6, N-terminal DUF4337 PF14235.6 CCF34765.1 - 1.8 8.7 4.1 27 4.8 4.1 2.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4337) MFS_1 PF07690.16 CCF34766.1 - 1.5e-52 178.7 23.9 1.5e-52 178.7 23.9 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF34766.1 - 3.7e-09 36.0 8.1 3.7e-09 36.0 8.1 2.7 3 0 0 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.13 CCF34766.1 - 1.5e-05 23.6 5.5 2.9e-05 22.7 5.5 1.4 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_5 PF05631.14 CCF34766.1 - 0.00027 20.0 4.8 0.00061 18.8 2.4 2.1 2 0 0 2 2 2 1 Sugar-tranasporters, 12 TM Fzo_mitofusin PF04799.13 CCF34766.1 - 0.0078 15.8 1.4 0.94 9.0 0.3 2.4 2 0 0 2 2 2 2 fzo-like conserved region OATP PF03137.20 CCF34766.1 - 0.013 13.8 7.3 0.061 11.6 1.3 2.5 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family DUF624 PF04854.14 CCF34766.1 - 0.088 12.9 0.1 0.088 12.9 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function, DUF624 Phage_holin_2_4 PF16082.5 CCF34766.1 - 0.55 10.0 6.1 3.5 7.4 0.0 3.5 3 0 0 3 3 3 0 Bacteriophage holin family, superfamily II-like MFS_3 PF05977.13 CCF34766.1 - 0.69 8.2 14.0 0.009 14.4 6.1 1.7 2 0 0 2 2 2 0 Transmembrane secretion effector GFA PF04828.14 CCF34767.1 - 1.1e-10 41.7 11.9 6.3e-07 29.6 0.6 2.8 3 0 0 3 3 3 2 Glutathione-dependent formaldehyde-activating enzyme NOB1_Zn_bind PF08772.11 CCF34767.1 - 0.052 13.7 2.0 6.7 6.9 0.1 2.7 2 0 0 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like Zn_clus PF00172.18 CCF34768.1 - 1.5e-07 31.4 11.5 2e-07 31.0 11.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Macro PF01661.21 CCF34768.1 - 0.0059 16.6 0.0 0.0069 16.4 0.0 1.0 1 0 0 1 1 1 1 Macro domain PTR2 PF00854.21 CCF34770.1 - 3.1e-90 302.9 5.2 7.4e-90 301.6 5.2 1.6 1 1 0 1 1 1 1 POT family DUF2104 PF09877.9 CCF34770.1 - 3.2 8.1 8.9 4.1 7.7 0.9 2.7 2 0 0 2 2 2 0 Predicted membrane protein (DUF2104) Glycos_transf_2 PF00535.26 CCF34772.1 - 1.5e-35 122.5 0.0 1.7e-35 122.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 CCF34772.1 - 7.7e-13 48.9 0.0 1e-12 48.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 CCF34772.1 - 3.6e-05 23.4 0.0 4.8e-05 23.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 CCF34772.1 - 5.1e-05 22.8 0.0 8.7e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 adh_short_C2 PF13561.6 CCF34773.1 - 2.2e-49 168.1 4.1 2.4e-39 135.3 3.4 2.0 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF34773.1 - 8e-45 152.7 3.4 1e-44 152.4 3.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF34773.1 - 6.9e-15 55.4 1.3 9.7e-15 54.9 1.3 1.2 1 0 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 CCF34773.1 - 0.0037 17.2 0.8 0.0061 16.5 0.8 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AdoHcyase_NAD PF00670.21 CCF34773.1 - 0.0079 16.3 0.6 0.012 15.6 0.6 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Gly_rich_SFCGS PF14272.6 CCF34773.1 - 0.029 14.4 0.3 0.076 13.0 0.3 1.8 1 0 0 1 1 1 0 Glycine-rich SFCGS UDPG_MGDP_dh_N PF03721.14 CCF34773.1 - 0.031 13.8 0.2 0.072 12.7 0.2 1.6 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain THF_DHG_CYH_C PF02882.19 CCF34773.1 - 0.037 13.4 0.5 0.074 12.4 0.2 1.6 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 2-Hacid_dh_C PF02826.19 CCF34773.1 - 0.084 12.2 0.2 0.13 11.6 0.2 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Ank_2 PF12796.7 CCF34775.1 - 1.4e-05 25.6 0.0 9.4e-05 22.9 0.0 2.4 3 0 0 3 3 3 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CCF34775.1 - 0.0031 17.9 0.6 1.3 9.8 0.0 3.8 4 0 0 4 4 4 1 Ankyrin repeat Ank_4 PF13637.6 CCF34775.1 - 0.005 17.4 1.0 0.2 12.3 0.1 3.7 4 0 0 4 4 4 1 Ankyrin repeats (many copies) AATase PF07247.12 CCF34776.1 - 3e-16 59.1 0.0 1.6e-12 46.8 0.0 2.3 2 1 0 2 2 2 2 Alcohol acetyltransferase Condensation PF00668.20 CCF34776.1 - 1.7e-06 27.0 0.1 0.0001 21.2 0.0 2.1 2 0 0 2 2 2 2 Condensation domain WES_acyltransf PF03007.16 CCF34776.1 - 0.0022 17.8 0.0 0.0051 16.6 0.0 1.5 1 0 0 1 1 1 1 Wax ester synthase-like Acyl-CoA acyltransferase domain Sedlin_N PF04628.13 CCF34778.1 - 5.9e-47 159.1 0.0 6.7e-47 158.9 0.0 1.0 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.12 CCF34778.1 - 0.00012 22.0 0.2 0.0097 15.8 0.0 2.2 1 1 1 2 2 2 2 Sybindin-like family CENP-T_C PF15511.6 CCF34779.1 - 8e-09 35.6 0.1 9.7e-09 35.3 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Histone PF00125.24 CCF34779.1 - 3.5e-05 24.2 0.1 4.1e-05 23.9 0.1 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TAF PF02969.17 CCF34779.1 - 8.6e-05 22.6 0.1 0.00013 22.1 0.1 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.23 CCF34779.1 - 0.00036 20.7 0.1 0.00065 19.9 0.0 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-S PF15630.6 CCF34779.1 - 0.00042 20.7 0.1 0.00056 20.2 0.1 1.4 1 1 0 1 1 1 1 CENP-S protein TFIID-31kDa PF02291.15 CCF34779.1 - 0.0087 16.1 0.0 0.01 15.9 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 CCF34779.1 - 0.023 14.7 0.0 0.027 14.5 0.0 1.3 1 0 0 1 1 1 0 Bromodomain associated UPF0137 PF03677.13 CCF34779.1 - 0.095 12.5 0.1 0.12 12.2 0.1 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0137) HIGH_NTase1_ass PF16581.5 CCF34779.1 - 0.11 12.5 0.0 0.12 12.4 0.0 1.1 1 0 0 1 1 1 0 Cytidyltransferase-related C-terminal region TPR_1 PF00515.28 CCF34780.1 - 1.4e-38 129.2 20.6 8.8e-07 28.5 0.1 9.7 10 0 0 10 10 9 7 Tetratricopeptide repeat TPR_2 PF07719.17 CCF34780.1 - 3.3e-30 101.7 29.5 0.00018 21.4 0.1 10.8 11 0 0 11 11 11 6 Tetratricopeptide repeat ANAPC3 PF12895.7 CCF34780.1 - 2.6e-26 91.7 18.2 5.5e-21 74.6 0.1 5.9 3 1 5 8 8 8 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 CCF34780.1 - 4.1e-26 89.0 12.5 0.0046 17.1 0.0 10.5 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_17 PF13431.6 CCF34780.1 - 1.7e-20 71.8 5.7 0.13 12.7 0.0 9.0 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_14 PF13428.6 CCF34780.1 - 1.2e-17 63.0 21.2 0.092 13.6 0.2 10.5 3 2 7 11 11 11 5 Tetratricopeptide repeat TPR_7 PF13176.6 CCF34780.1 - 2.9e-16 58.2 7.9 0.038 14.0 0.0 7.7 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_19 PF14559.6 CCF34780.1 - 7.7e-16 58.4 14.7 5.1e-05 23.7 0.7 7.8 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_16 PF13432.6 CCF34780.1 - 1e-15 58.1 17.6 4.4e-07 30.4 0.2 8.0 7 1 0 8 8 8 3 Tetratricopeptide repeat TPR_12 PF13424.6 CCF34780.1 - 1.2e-15 57.5 22.9 0.016 15.5 0.0 8.9 4 2 3 8 8 8 6 Tetratricopeptide repeat TPR_11 PF13414.6 CCF34780.1 - 3.2e-15 55.5 10.5 0.00011 21.8 1.1 9.5 7 1 4 11 11 11 3 TPR repeat TPR_6 PF13174.6 CCF34780.1 - 1.4e-09 37.9 10.3 2.6 8.9 0.0 9.4 11 0 0 11 11 9 3 Tetratricopeptide repeat TPR_15 PF13429.6 CCF34780.1 - 1.5e-06 27.7 11.8 0.13 11.5 0.4 4.2 2 1 0 3 3 3 3 Tetratricopeptide repeat DUF2225 PF09986.9 CCF34780.1 - 0.00012 21.9 4.7 0.096 12.4 0.0 3.6 2 1 2 4 4 4 1 Uncharacterized protein conserved in bacteria (DUF2225) TPR_9 PF13371.6 CCF34780.1 - 0.041 14.0 9.0 12 6.2 0.2 5.8 5 2 2 7 7 7 0 Tetratricopeptide repeat RGS PF00615.19 CCF34782.1 - 2.4e-05 24.6 0.0 0.00026 21.3 0.0 2.1 2 0 0 2 2 2 1 Regulator of G protein signaling domain MRAP PF15183.6 CCF34782.1 - 0.8 9.7 3.5 4.4 7.3 0.3 2.4 2 0 0 2 2 2 0 Melanocortin-2 receptor accessory protein family GTP_EFTU PF00009.27 CCF34783.1 - 5.3e-48 163.1 0.0 1.1e-47 162.2 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain HBS1_N PF08938.10 CCF34783.1 - 7.7e-24 83.8 1.9 1.6e-23 82.8 1.9 1.5 1 0 0 1 1 1 1 HBS1 N-terminus MMR_HSR1 PF01926.23 CCF34783.1 - 8.4e-10 38.7 0.0 9.8e-06 25.6 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase GTP_EFTU_D3 PF03143.17 CCF34783.1 - 1.1e-08 35.4 0.0 2.7e-08 34.1 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 CCF34783.1 - 7.9e-08 32.6 0.2 2.5e-07 31.0 0.2 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 Roc PF08477.13 CCF34783.1 - 9.3e-05 22.6 0.0 0.0089 16.2 0.0 2.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 CCF34783.1 - 0.0054 16.3 0.1 0.088 12.4 0.0 2.3 2 0 0 2 2 2 1 Ras family Septin PF00735.18 CCF34783.1 - 0.01 15.1 0.0 0.017 14.4 0.0 1.3 1 0 0 1 1 1 0 Septin SRPRB PF09439.10 CCF34783.1 - 0.06 12.8 0.0 2.4 7.5 0.0 2.3 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit GTP_EFTU_D4 PF14578.6 CCF34783.1 - 0.083 12.8 0.3 0.19 11.6 0.3 1.7 1 0 0 1 1 1 0 Elongation factor Tu domain 4 FeoB_N PF02421.18 CCF34783.1 - 0.086 12.4 0.0 1.6 8.3 0.0 2.6 2 1 0 2 2 2 0 Ferrous iron transport protein B Cpn60_TCP1 PF00118.24 CCF34784.1 - 1.2e-159 532.1 5.8 1.3e-159 532.0 5.8 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Enolase_N PF03952.16 CCF34784.1 - 0.3 11.2 3.1 15 5.8 0.1 3.2 3 0 0 3 3 3 0 Enolase, N-terminal domain His_Phos_1 PF00300.22 CCF34785.1 - 2.6e-07 30.5 0.4 6.6e-07 29.2 0.0 1.6 1 1 1 2 2 2 1 Histidine phosphatase superfamily (branch 1) MFS_1 PF07690.16 CCF34786.1 - 5.6e-19 68.3 57.1 2.4e-11 43.2 28.6 3.4 2 1 0 3 3 3 2 Major Facilitator Superfamily TRI12 PF06609.13 CCF34786.1 - 9.7e-08 30.9 22.8 1.4e-07 30.4 22.8 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) HET PF06985.11 CCF34787.1 - 6.8e-26 91.4 0.0 1.5e-25 90.3 0.0 1.6 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) SdpI PF13630.6 CCF34787.1 - 0.17 12.0 0.0 0.49 10.6 0.0 1.7 1 0 0 1 1 1 0 SdpI/YhfL protein family Chitin_synth_2 PF03142.15 CCF34789.1 - 4.8e-25 88.2 0.3 8.8e-25 87.3 0.3 1.3 1 1 0 1 1 1 1 Chitin synthase Glyco_tranf_2_3 PF13641.6 CCF34789.1 - 3.5e-12 46.7 0.6 4.9e-12 46.2 0.6 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 CCF34789.1 - 3e-09 37.1 4.5 5e-09 36.3 4.4 1.5 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 CCF34789.1 - 0.014 15.2 0.0 0.05 13.4 0.0 2.0 2 0 0 2 2 2 0 Glycosyl transferase family 2 AMP-binding PF00501.28 CCF34790.1 - 1.1e-72 245.0 0.0 1.6e-72 244.5 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme Condensation PF00668.20 CCF34790.1 - 1.6e-32 112.8 0.0 3.2e-32 111.8 0.0 1.5 1 1 0 1 1 1 1 Condensation domain PP-binding PF00550.25 CCF34790.1 - 3.2e-06 27.4 0.1 7.6e-06 26.2 0.1 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site AMP-binding_C PF13193.6 CCF34790.1 - 0.031 15.2 0.0 0.078 14.0 0.0 1.8 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain WES_acyltransf PF03007.16 CCF34790.1 - 0.066 13.0 0.0 0.18 11.6 0.0 1.7 1 0 0 1 1 1 0 Wax ester synthase-like Acyl-CoA acyltransferase domain HTH_28 PF13518.6 CCF34793.1 - 0.15 12.2 0.1 0.23 11.6 0.1 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain Cas_csx3 PF09620.10 CCF34794.1 - 0.019 14.9 0.0 0.031 14.2 0.0 1.4 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_csx3) Glyco_hydro_43 PF04616.14 CCF34795.1 - 8.2e-63 212.4 2.9 1e-62 212.1 2.9 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 GH43_C2 PF17851.1 CCF34795.1 - 1.2e-11 44.7 0.0 2.1e-11 44.0 0.0 1.4 1 0 0 1 1 1 1 Beta xylosidase C-terminal Concanavalin A-like domain PhoLip_ATPase_C PF16212.5 CCF34796.1 - 1.1e-80 271.1 20.8 1.1e-80 271.1 20.8 2.2 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 CCF34796.1 - 5.4e-27 93.3 7.1 1.3e-26 92.0 7.1 1.7 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 CCF34796.1 - 9.8e-12 44.8 0.0 6.9e-11 42.1 0.0 2.2 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 CCF34796.1 - 6.8e-11 42.9 2.5 3.1e-06 27.6 0.6 3.1 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 CCF34796.1 - 2e-08 34.0 0.0 4.9e-08 32.7 0.0 1.7 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.12 CCF34796.1 - 0.0025 17.6 0.3 0.006 16.4 0.3 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Asp PF00026.23 CCF34798.1 - 6.7e-59 199.9 1.9 8.1e-59 199.6 1.9 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCF34798.1 - 6e-12 46.2 0.7 6e-11 42.9 0.3 2.6 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal gag-asp_proteas PF13975.6 CCF34798.1 - 4.8e-05 23.8 0.0 0.07 13.7 0.0 3.3 2 2 0 2 2 2 2 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 CCF34798.1 - 0.00013 22.6 0.1 0.19 12.4 0.0 3.1 2 1 0 2 2 2 2 Aspartyl protease Glyco_hydro_17 PF00332.18 CCF34799.1 - 1.4e-35 123.4 0.2 4.3e-35 121.8 0.2 1.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 17 fn3_5 PF06280.12 CCF34802.1 - 1.4e-09 38.6 0.0 6.6e-09 36.5 0.0 1.9 2 0 0 2 2 2 1 Fn3-like domain ASH PF15780.5 CCF34802.1 - 0.0005 20.2 0.1 0.0017 18.5 0.1 1.9 2 0 0 2 2 2 1 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin DUF916 PF06030.12 CCF34802.1 - 0.0041 17.2 0.0 0.0067 16.5 0.0 1.2 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF916) DUF4232 PF14016.6 CCF34802.1 - 0.17 12.1 0.0 0.58 10.3 0.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF4232) adh_short_C2 PF13561.6 CCF34803.1 - 3.7e-52 177.2 0.1 5.4e-52 176.7 0.1 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF34803.1 - 6.2e-40 136.7 1.1 1e-39 136.1 1.1 1.3 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF34803.1 - 2.5e-08 34.1 0.8 3.8e-08 33.5 0.8 1.3 1 0 0 1 1 1 1 KR domain MR_MLE_C PF13378.6 CCF34804.1 - 2e-42 145.3 0.0 2.6e-42 144.9 0.0 1.1 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 CCF34804.1 - 4.4e-09 36.6 0.0 1e-08 35.4 0.0 1.5 2 0 0 2 2 2 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain Glyco_hydro_42 PF02449.15 CCF34804.1 - 0.034 13.5 0.0 0.28 10.5 0.0 1.9 2 0 0 2 2 2 0 Beta-galactosidase Nuc_deoxyri_tr2 PF15891.5 CCF34805.1 - 3.1e-37 127.2 0.0 4e-37 126.8 0.0 1.1 1 0 0 1 1 1 1 Nucleoside 2-deoxyribosyltransferase like Peptidase_M20 PF01546.28 CCF34806.1 - 5.4e-24 85.0 0.0 9.9e-23 80.9 0.0 2.5 2 1 0 2 2 2 1 Peptidase family M20/M25/M40 WD40 PF00400.32 CCF34806.1 - 8.2e-14 51.8 2.9 0.083 13.8 0.0 7.1 7 0 0 7 7 7 3 WD domain, G-beta repeat Peptidase_M28 PF04389.17 CCF34806.1 - 0.0042 16.8 0.0 0.01 15.5 0.0 1.6 1 0 0 1 1 1 1 Peptidase family M28 M20_dimer PF07687.14 CCF34806.1 - 0.0088 16.0 0.0 0.018 14.9 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain TFIIE-A_C PF11521.8 CCF34806.1 - 0.08 13.3 0.0 0.19 12.0 0.0 1.6 1 0 0 1 1 1 0 C-terminal general transcription factor TFIIE alpha Invas_SpaK PF03519.14 CCF34806.1 - 0.11 12.5 0.6 1.2 9.3 0.0 2.6 3 0 0 3 3 3 0 Invasion protein B family Ge1_WD40 PF16529.5 CCF34806.1 - 0.11 11.4 0.1 0.53 9.2 0.0 2.0 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 CCF34806.1 - 0.12 11.1 0.1 1.4 7.5 0.0 2.4 3 0 0 3 3 3 0 Nup133 N terminal like Asparaginase_2 PF01112.18 CCF34807.1 - 3.7e-21 75.5 0.0 4.7e-21 75.1 0.0 1.1 1 0 0 1 1 1 1 Asparaginase Ribosomal_L24e PF01246.20 CCF34809.1 - 4.2e-28 97.4 0.1 4.2e-28 97.4 0.1 1.8 2 0 0 2 2 2 1 Ribosomal protein L24e A_deamin PF02137.18 CCF34810.1 - 1.2e-30 107.1 0.0 1.5e-30 106.8 0.0 1.1 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain NAC PF01849.18 CCF34811.1 - 1.9e-24 85.4 0.3 8.3e-24 83.3 0.1 2.0 2 0 0 2 2 2 1 NAC domain CBP4 PF07960.11 CCF34812.1 - 3.1e-05 23.8 1.1 4.5e-05 23.3 1.1 1.2 1 0 0 1 1 1 1 CBP4 DUF3854 PF12965.7 CCF34812.1 - 0.09 12.8 0.1 0.093 12.7 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3854) Alba PF01918.21 CCF34813.1 - 2e-05 24.3 0.0 4.6e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 Alba DUF202 PF02656.15 CCF34814.1 - 8.4e-16 58.2 3.5 8.4e-16 58.2 3.5 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF202) Tctex-1 PF03645.13 CCF34815.1 - 7.1e-40 135.4 0.0 8.2e-40 135.2 0.0 1.0 1 0 0 1 1 1 1 Tctex-1 family tRNA_int_endo PF01974.17 CCF34816.1 - 8e-17 61.1 0.0 1.9e-16 59.9 0.0 1.6 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain tRNA_int_endo_N PF02778.14 CCF34816.1 - 0.004 16.8 0.0 0.59 9.8 0.0 2.5 2 0 0 2 2 2 2 tRNA intron endonuclease, N-terminal domain Glyco_transf_21 PF13506.6 CCF34817.1 - 7.3e-13 48.4 0.0 0.00039 19.9 0.0 3.2 3 0 0 3 3 3 3 Glycosyl transferase family 21 Glyco_tranf_2_3 PF13641.6 CCF34817.1 - 2e-08 34.4 0.0 4.2e-07 30.1 0.0 2.4 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 CCF34817.1 - 0.0025 17.7 0.0 0.012 15.4 0.0 1.9 2 0 0 2 2 2 1 Glycosyl transferase family 2 BioY PF02632.14 CCF34817.1 - 0.0096 16.0 0.7 0.021 14.9 0.7 1.5 1 0 0 1 1 1 1 BioY family EF-hand_7 PF13499.6 CCF34818.1 - 3.4e-07 30.6 0.0 0.00017 22.0 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 CCF34818.1 - 4.3e-07 29.0 0.0 0.0052 16.2 0.0 3.2 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 CCF34818.1 - 0.00017 21.3 0.0 0.036 14.0 0.0 2.8 2 1 0 2 2 2 1 EF-hand domain EF-hand_4 PF12763.7 CCF34818.1 - 0.018 15.0 0.0 1.1 9.2 0.0 2.1 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand Phage_ABA_S PF18066.1 CCF34818.1 - 0.089 13.5 0.0 1.5 9.6 0.0 2.1 2 0 0 2 2 2 0 Phage ABA sandwich domain EF-hand_8 PF13833.6 CCF34818.1 - 0.17 11.7 0.1 0.35 10.7 0.1 1.6 1 0 0 1 1 1 0 EF-hand domain pair ParA PF10609.9 CCF34819.1 - 2.5e-95 318.6 0.0 2.8e-95 318.4 0.0 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 CCF34819.1 - 1.8e-10 40.9 0.0 3.7e-10 40.0 0.0 1.6 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 CCF34819.1 - 3.4e-09 36.9 0.7 2.9e-07 30.6 0.7 2.1 1 1 0 1 1 1 1 AAA domain ArsA_ATPase PF02374.15 CCF34819.1 - 2.2e-05 23.8 0.4 0.0027 16.9 0.0 2.9 2 1 1 3 3 3 1 Anion-transporting ATPase Fer4_NifH PF00142.18 CCF34819.1 - 7.8e-05 22.3 0.0 0.13 11.7 0.0 2.4 2 1 0 2 2 2 2 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family MipZ PF09140.11 CCF34819.1 - 8.1e-05 22.0 0.0 0.0001 21.7 0.0 1.2 1 0 0 1 1 1 1 ATPase MipZ CBP_BcsQ PF06564.12 CCF34819.1 - 0.00078 19.0 0.2 0.013 15.0 0.1 2.0 2 0 0 2 2 2 1 Cellulose biosynthesis protein BcsQ AAA_26 PF13500.6 CCF34819.1 - 0.0037 17.1 0.7 0.14 12.0 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 CCF34819.1 - 0.016 14.8 0.0 0.032 13.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain MeaB PF03308.16 CCF34819.1 - 0.18 10.7 0.1 0.3 10.0 0.1 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Zn_Tnp_IS1595 PF12760.7 CCF34819.1 - 0.22 11.5 0.4 0.46 10.5 0.4 1.5 1 0 0 1 1 1 0 Transposase zinc-ribbon domain Tudor_3 PF18115.1 CCF34820.1 - 1.2e-06 28.3 0.0 1.9e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 DNA repair protein Crb2 Tudor domain FlxA PF14282.6 CCF34820.1 - 0.00055 19.9 1.1 0.00055 19.9 1.1 1.8 2 1 0 2 2 2 1 FlxA-like protein DUF4537 PF15057.6 CCF34820.1 - 0.0027 17.7 0.0 0.005 16.8 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4537) IL11 PF07400.11 CCF34820.1 - 0.011 15.3 0.5 0.018 14.7 0.5 1.4 1 0 0 1 1 1 0 Interleukin 11 LBR_tudor PF09465.10 CCF34820.1 - 0.019 14.7 0.0 0.036 13.9 0.0 1.5 1 0 0 1 1 1 0 Lamin-B receptor of TUDOR domain DUF1325 PF07039.11 CCF34820.1 - 0.024 14.7 0.8 0.051 13.7 0.1 1.9 2 0 0 2 2 2 0 SGF29 tudor-like domain CCDC-167 PF15188.6 CCF34820.1 - 0.66 10.4 4.3 1.6 9.2 1.0 2.2 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 TCO89 PF10452.9 CCF34821.1 - 1.1e-05 24.6 30.3 0.00032 19.8 0.2 3.3 3 0 0 3 3 3 2 TORC1 subunit TCO89 Beta_elim_lyase PF01212.21 CCF34822.1 - 2.1e-71 240.6 0.0 2.6e-71 240.3 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.20 CCF34822.1 - 8.1e-05 21.3 0.0 0.00017 20.3 0.0 1.4 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 CCF34822.1 - 0.00085 18.6 0.0 0.0011 18.2 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 CCF34822.1 - 0.0074 15.3 0.0 0.011 14.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 CCF34822.1 - 0.018 14.3 0.0 0.032 13.6 0.0 1.3 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Trehalase PF01204.18 CCF34823.1 - 2e-117 393.1 9.1 1.3e-116 390.5 9.1 1.9 1 1 0 1 1 1 1 Trehalase GDE_C PF06202.14 CCF34823.1 - 0.00042 19.4 0.7 0.0011 18.0 0.0 1.8 2 0 0 2 2 2 1 Amylo-alpha-1,6-glucosidase DUF2981 PF11200.8 CCF34824.1 - 0.01 15.6 0.9 0.014 15.2 0.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) OCD_Mu_crystall PF02423.15 CCF34824.1 - 0.18 10.7 0.0 0.24 10.3 0.0 1.1 1 0 0 1 1 1 0 Ornithine cyclodeaminase/mu-crystallin family DEAD_2 PF06733.15 CCF34825.1 - 1.5e-57 194.0 0.3 3.5e-57 192.8 0.3 1.7 1 0 0 1 1 1 1 DEAD_2 HBB PF06777.11 CCF34825.1 - 5.2e-49 166.5 1.1 3.5e-44 150.8 0.2 2.5 2 0 0 2 2 2 2 Helical and beta-bridge domain Helicase_C_2 PF13307.6 CCF34825.1 - 1.1e-43 149.4 0.0 3.9e-43 147.6 0.0 2.0 2 0 0 2 2 2 1 Helicase C-terminal domain ResIII PF04851.15 CCF34825.1 - 8.8e-05 22.6 0.0 0.0064 16.5 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 CCF34825.1 - 0.00025 20.9 0.0 0.049 13.4 0.0 2.4 2 0 0 2 2 2 1 DEAD/DEAH box helicase SNF2_N PF00176.23 CCF34825.1 - 0.0026 16.5 0.0 0.018 13.8 0.0 2.0 1 1 0 1 1 1 1 SNF2 family N-terminal domain AAA_22 PF13401.6 CCF34825.1 - 0.015 15.6 0.2 1.5 9.1 0.0 2.6 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.9 CCF34825.1 - 0.033 13.4 0.7 1.1 8.4 0.0 2.5 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2075) Stomoxyn PF11585.8 CCF34825.1 - 0.064 13.3 0.2 0.15 12.1 0.2 1.6 1 0 0 1 1 1 0 Insect antimicrobial peptide, stomoxyn PhoH PF02562.16 CCF34825.1 - 0.13 11.6 0.0 8.3 5.8 0.0 2.5 2 0 0 2 2 2 0 PhoH-like protein AAA_11 PF13086.6 CCF34825.1 - 0.31 10.8 1.1 1.1 8.9 1.1 1.9 1 1 0 1 1 1 0 AAA domain DDHD PF02862.17 CCF34826.1 - 1e-24 88.0 0.0 1.2e-12 48.5 0.0 2.1 1 1 0 2 2 2 2 DDHD domain Tyrosinase PF00264.20 CCF34828.1 - 5.2e-49 167.5 2.9 8.1e-49 166.9 2.9 1.3 1 0 0 1 1 1 1 Common central domain of tyrosinase Tyosinase_C PF18132.1 CCF34828.1 - 2.9e-38 131.3 0.0 4.7e-38 130.6 0.0 1.3 1 0 0 1 1 1 1 Tyosinase C-terminal domain ABC_membrane PF00664.23 CCF34829.1 - 6.9e-36 124.3 32.4 2.6e-25 89.6 12.9 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 CCF34829.1 - 4e-35 121.3 0.0 5e-16 59.5 0.0 3.1 3 0 0 3 3 2 2 ABC transporter AAA_21 PF13304.6 CCF34829.1 - 2.8e-07 30.7 3.3 0.011 15.5 0.3 3.0 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system T2SSE PF00437.20 CCF34829.1 - 3.3e-07 29.6 0.5 0.019 14.0 0.1 2.5 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_22 PF13401.6 CCF34829.1 - 1.3e-06 28.7 1.6 0.0044 17.3 0.0 3.0 4 0 0 4 4 2 2 AAA domain SMC_N PF02463.19 CCF34829.1 - 1.5e-06 27.8 0.0 0.0032 16.9 0.0 2.8 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 CCF34829.1 - 5.2e-06 26.9 0.1 0.11 12.9 0.0 2.9 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 CCF34829.1 - 5.6e-06 26.0 0.8 0.0024 17.6 0.1 2.9 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_33 PF13671.6 CCF34829.1 - 6.4e-05 23.1 0.0 0.13 12.4 0.0 2.6 2 0 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 CCF34829.1 - 9.4e-05 22.4 2.0 0.07 13.0 0.1 2.6 2 0 0 2 2 2 2 RsgA GTPase SbcCD_C PF13558.6 CCF34829.1 - 0.00031 20.9 2.2 1.2 9.4 0.4 3.9 3 1 0 3 3 2 2 Putative exonuclease SbcCD, C subunit AAA_7 PF12775.7 CCF34829.1 - 0.00054 19.5 0.4 0.5 9.8 0.1 2.3 2 0 0 2 2 2 2 P-loop containing dynein motor region TsaE PF02367.17 CCF34829.1 - 0.0051 16.8 0.4 1.1 9.3 0.0 2.4 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_25 PF13481.6 CCF34829.1 - 0.0062 16.1 0.6 1.8 8.1 0.0 2.6 2 0 0 2 2 2 1 AAA domain FtsK_SpoIIIE PF01580.18 CCF34829.1 - 0.0076 15.6 0.3 0.028 13.8 0.0 1.9 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA PF00004.29 CCF34829.1 - 0.016 15.7 0.1 1.3 9.5 0.1 2.8 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 CCF34829.1 - 0.02 14.2 1.5 1.7 7.9 0.1 2.9 3 0 0 3 3 3 0 Zeta toxin MMR_HSR1 PF01926.23 CCF34829.1 - 0.022 14.8 0.6 1.6 8.8 0.0 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase cobW PF02492.19 CCF34829.1 - 0.027 14.1 3.5 2.8 7.5 0.2 2.6 3 0 0 3 3 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.6 CCF34829.1 - 0.029 14.9 0.1 8.4 7.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 CCF34829.1 - 0.041 13.8 0.4 1.8 8.5 0.0 2.4 2 0 0 2 2 2 0 NTPase AAA_23 PF13476.6 CCF34829.1 - 0.041 14.4 0.1 0.72 10.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 CCF34829.1 - 0.05 13.0 0.1 1.8 7.9 0.0 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Viral_helicase1 PF01443.18 CCF34829.1 - 0.055 13.2 0.8 3.8 7.2 0.1 2.9 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase NACHT PF05729.12 CCF34829.1 - 0.079 12.9 3.0 4 7.3 0.1 3.7 4 0 0 4 4 3 0 NACHT domain MobB PF03205.14 CCF34829.1 - 0.081 12.8 0.5 11 5.9 0.1 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Septin PF00735.18 CCF34829.1 - 0.13 11.5 0.3 11 5.1 0.0 2.4 2 0 0 2 2 2 0 Septin ATP_bind_1 PF03029.17 CCF34829.1 - 0.14 12.0 1.3 9.8 5.9 0.3 2.6 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Dynamin_N PF00350.23 CCF34829.1 - 0.15 12.1 2.3 3.8 7.6 0.1 2.5 2 0 0 2 2 2 0 Dynamin family AAA_15 PF13175.6 CCF34829.1 - 0.18 11.5 0.1 0.39 10.4 0.0 1.6 2 0 0 2 2 1 0 AAA ATPase domain RNA_helicase PF00910.22 CCF34829.1 - 0.29 11.5 0.9 21 5.6 0.0 2.9 3 0 0 3 3 2 0 RNA helicase CbiA PF01656.23 CCF34829.1 - 0.33 11.0 1.2 7.1 6.7 0.2 3.0 3 0 0 3 3 3 0 CobQ/CobB/MinD/ParA nucleotide binding domain dNK PF01712.19 CCF34829.1 - 0.39 10.6 3.3 5 6.9 0.1 2.6 3 0 0 3 3 2 0 Deoxynucleoside kinase Roc PF08477.13 CCF34829.1 - 0.55 10.5 2.1 53 4.1 0.0 3.3 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase DUF2530 PF10745.9 CCF34829.1 - 4.5 7.6 8.0 4.3 7.6 0.0 3.8 3 0 0 3 3 2 0 Protein of unknown function (DUF2530) Kp4 PF09044.10 CCF34830.1 - 1.7e-39 134.8 0.2 2.3e-39 134.3 0.2 1.1 1 0 0 1 1 1 1 Kp4 MU117 PF15474.6 CCF34830.1 - 0.00021 22.0 0.0 0.00027 21.7 0.0 1.2 1 0 0 1 1 1 1 Meiotically up-regulated gene family AAA_12 PF13087.6 CCF34832.1 - 3e-17 62.9 0.0 4.6e-17 62.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 CCF34832.1 - 4.9e-09 36.4 0.0 3.6e-08 33.5 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CCF34832.1 - 1.2e-08 34.9 0.3 0.0003 20.6 0.1 2.6 3 0 0 3 3 2 2 AAA domain AAA_19 PF13245.6 CCF34832.1 - 0.00011 22.5 0.0 0.00033 21.0 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.6 CCF34832.1 - 0.00059 19.5 0.3 0.0034 17.0 0.0 2.3 3 0 0 3 3 3 1 AAA domain AAA_33 PF13671.6 CCF34832.1 - 0.0053 16.9 1.3 0.014 15.5 0.1 2.3 3 0 0 3 3 2 1 AAA domain NACHT PF05729.12 CCF34832.1 - 0.0069 16.3 0.0 0.015 15.2 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_34 PF13872.6 CCF34832.1 - 0.014 14.3 0.0 0.023 13.6 0.0 1.2 1 0 0 1 1 1 0 P-loop containing NTP hydrolase pore-1 KTI12 PF08433.10 CCF34832.1 - 0.025 14.1 0.0 0.042 13.3 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_24 PF13479.6 CCF34832.1 - 0.028 14.1 0.0 0.059 13.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 CCF34832.1 - 0.03 14.2 0.1 0.22 11.4 0.0 2.4 2 0 0 2 2 2 0 NTPase AAA_22 PF13401.6 CCF34832.1 - 0.033 14.4 0.1 0.35 11.1 0.0 2.6 3 0 0 3 3 3 0 AAA domain AAA_28 PF13521.6 CCF34832.1 - 0.043 14.1 0.3 0.21 11.8 0.1 2.2 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.6 CCF34832.1 - 0.048 14.1 0.1 0.11 12.9 0.1 1.7 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 CCF34832.1 - 0.049 12.7 0.0 0.081 12.0 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein CbiA PF01656.23 CCF34832.1 - 0.061 13.4 0.1 0.12 12.4 0.1 1.5 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain IstB_IS21 PF01695.17 CCF34832.1 - 0.089 12.5 0.0 0.25 11.0 0.0 1.7 1 0 0 1 1 1 0 IstB-like ATP binding protein DnaB_C PF03796.15 CCF34832.1 - 0.1 11.9 0.1 0.19 11.0 0.1 1.4 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain AAA_18 PF13238.6 CCF34832.1 - 0.11 13.0 0.1 0.33 11.5 0.0 1.9 2 0 0 2 2 1 0 AAA domain AAA PF00004.29 CCF34832.1 - 0.22 12.0 0.3 0.95 9.9 0.1 2.1 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) ADH_N PF08240.12 CCF34834.1 - 1.5e-18 66.7 0.3 4.8e-18 65.0 0.2 2.0 2 1 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCF34834.1 - 0.0002 21.3 0.3 0.17 11.9 0.1 2.2 2 0 0 2 2 2 2 Zinc-binding dehydrogenase HI0933_like PF03486.14 CCF34834.1 - 0.00056 18.7 0.2 0.0007 18.4 0.2 1.1 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_2 PF07992.14 CCF34834.1 - 0.077 12.2 0.0 0.1 11.8 0.0 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCF34834.1 - 0.081 12.5 0.2 0.19 11.3 0.1 1.5 2 0 0 2 2 2 0 FAD dependent oxidoreductase Glu_dehyd_C PF16912.5 CCF34834.1 - 0.087 12.3 0.1 0.65 9.5 0.0 1.9 2 0 0 2 2 2 0 Glucose dehydrogenase C-terminus FAD_binding_2 PF00890.24 CCF34834.1 - 0.34 9.9 1.2 0.48 9.4 1.2 1.2 1 0 0 1 1 1 0 FAD binding domain MFS_1 PF07690.16 CCF34835.1 - 1.2e-40 139.5 20.3 1.2e-40 139.5 20.3 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF1772 PF08592.11 CCF34835.1 - 0.81 10.0 6.8 6.1 7.2 0.1 3.0 2 2 0 2 2 2 0 Domain of unknown function (DUF1772) Phage_holin_5_2 PF16079.5 CCF34835.1 - 7.3 7.0 13.9 22 5.5 1.7 3.7 2 1 1 3 3 3 0 Phage holin family Hol44, in holin superfamily V Pec_lyase_C PF00544.19 CCF34836.1 - 1.1e-15 57.8 8.0 1.7e-14 53.9 8.0 2.1 1 1 0 1 1 1 1 Pectate lyase Beta_helix PF13229.6 CCF34836.1 - 4.1e-07 30.0 13.1 0.0021 17.9 1.0 2.2 1 1 1 2 2 2 2 Right handed beta helix region Phage_attach PF05354.11 CCF34836.1 - 0.0038 17.1 0.1 0.011 15.6 0.1 1.7 1 0 0 1 1 1 1 Phage Head-Tail Attachment ERCC4 PF02732.15 CCF34837.1 - 4.6e-32 111.4 0.0 8e-32 110.6 0.0 1.4 1 0 0 1 1 1 1 ERCC4 domain DUF724 PF05266.14 CCF34837.1 - 0.062 13.1 5.9 0.14 12.0 5.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DUF4355 PF14265.6 CCF34837.1 - 0.066 13.5 13.4 0.19 12.0 13.4 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4355) CPSF100_C PF13299.6 CCF34837.1 - 0.29 11.3 11.7 0.44 10.7 7.7 2.3 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal XRN_N PF03159.18 CCF34837.1 - 0.48 9.8 8.6 0.25 10.7 0.3 2.3 2 0 0 2 2 2 0 XRN 5'-3' exonuclease N-terminus Tim54 PF11711.8 CCF34837.1 - 0.51 9.1 12.7 3.3 6.4 8.5 2.2 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 NAM-associated PF14303.6 CCF34837.1 - 7.8 7.2 21.1 0.45 11.2 13.7 2.4 2 0 0 2 2 2 0 No apical meristem-associated C-terminal domain RR_TM4-6 PF06459.12 CCF34837.1 - 8.8 6.1 14.8 0.89 9.3 9.1 1.9 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 His_Phos_1 PF00300.22 CCF34838.1 - 8.4e-23 81.1 1.6 1.2e-22 80.5 0.9 1.7 1 1 1 2 2 2 1 Histidine phosphatase superfamily (branch 1) His_Phos_2 PF00328.22 CCF34838.1 - 0.21 10.9 0.3 0.31 10.3 0.3 1.2 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 2) DUF724 PF05266.14 CCF34839.1 - 0.0043 16.9 1.0 0.019 14.8 0.7 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF724) DUF3934 PF13070.6 CCF34839.1 - 0.025 15.0 0.6 0.025 15.0 0.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3934) DUF591 PF04569.14 CCF34839.1 - 3.1 7.9 5.0 27 4.9 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function Glyco_transf_90 PF05686.12 CCF34840.1 - 3.6e-09 36.0 0.0 0.00041 19.4 0.0 3.3 3 1 0 3 3 3 3 Glycosyl transferase family 90 DUF1079 PF06435.11 CCF34842.1 - 3.9 7.8 5.0 19 5.6 0.0 3.1 3 1 0 3 3 3 0 Repeat of unknown function (DUF1079) ADH_zinc_N PF00107.26 CCF34844.1 - 8.9e-14 51.6 0.0 1.7e-13 50.6 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCF34844.1 - 6.2e-10 40.2 0.0 1.1e-09 39.5 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCF34844.1 - 2.3e-05 24.2 0.1 4.3e-05 23.3 0.1 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Gag_spuma PF03276.14 CCF34844.1 - 0.13 10.7 0.7 0.2 10.1 0.7 1.2 1 0 0 1 1 1 0 Spumavirus gag protein DUF676 PF05057.14 CCF34845.1 - 3.9e-05 23.3 0.0 6e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Hydrolase_4 PF12146.8 CCF34845.1 - 0.0068 15.7 0.0 0.014 14.7 0.0 1.5 1 0 0 1 1 1 1 Serine aminopeptidase, S33 F_bP_aldolase PF01116.20 CCF34846.1 - 3.1e-72 243.4 0.0 3.5e-72 243.2 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II CobS PF02654.15 CCF34846.1 - 0.16 12.2 0.6 0.55 10.4 0.0 2.0 2 0 0 2 2 2 0 Cobalamin-5-phosphate synthase IMS PF00817.20 CCF34847.1 - 1.1e-42 145.5 0.1 2.1e-42 144.7 0.1 1.5 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 CCF34847.1 - 2.1e-14 54.2 1.1 3.2e-14 53.6 0.1 1.8 2 0 0 2 2 2 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 CCF34847.1 - 0.00054 20.1 0.0 0.0014 18.8 0.0 1.8 1 0 0 1 1 1 1 IMS family HHH motif Arg_repressor PF01316.21 CCF34847.1 - 0.21 11.3 3.1 0.54 10.0 2.0 2.1 2 0 0 2 2 2 0 Arginine repressor, DNA binding domain RGS PF00615.19 CCF34848.1 - 0.00034 20.9 0.0 0.0011 19.2 0.0 1.8 1 1 0 1 1 1 1 Regulator of G protein signaling domain Oxidored_q3 PF00499.20 CCF34848.1 - 0.33 10.7 4.5 1.2 8.8 4.5 2.1 1 1 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 zf-rbx1 PF12678.7 CCF34849.1 - 2.2e-11 43.8 1.5 1.2e-09 38.3 0.3 2.1 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 CCF34849.1 - 4.6e-11 42.9 5.3 2.3e-09 37.4 1.0 2.1 2 0 0 2 2 2 2 Ring finger domain zf-C3HC4_2 PF13923.6 CCF34849.1 - 5.3e-09 35.8 3.3 1.4e-06 28.1 0.6 2.2 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CCF34849.1 - 2.9e-08 33.4 3.0 1.6e-07 31.1 3.0 1.9 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CCF34849.1 - 1.8e-07 30.9 2.4 3.6e-06 26.7 0.4 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CCF34849.1 - 1.6e-06 28.0 2.1 9.6e-06 25.5 0.5 2.1 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 CCF34849.1 - 1.7e-06 27.8 1.2 1.7e-06 27.8 1.2 1.9 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 CCF34849.1 - 1.1e-05 25.3 6.3 0.00064 19.7 0.1 3.0 2 1 1 3 3 3 2 RING-type zinc-finger Zn_ribbon_17 PF17120.5 CCF34849.1 - 0.00019 21.0 1.2 0.00019 21.0 1.2 1.7 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type zf-ANAPC11 PF12861.7 CCF34849.1 - 0.0003 20.8 0.8 0.00069 19.6 0.2 1.8 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 CCF34849.1 - 0.00073 19.2 5.5 0.36 10.6 0.1 3.0 3 0 0 3 3 3 2 RING-like zinc finger zf-P11 PF03854.14 CCF34849.1 - 0.0022 17.6 0.5 0.0022 17.6 0.5 1.9 2 0 0 2 2 2 1 P-11 zinc finger zf-RING_10 PF16685.5 CCF34849.1 - 0.006 16.7 1.1 0.065 13.4 0.1 2.0 2 0 0 2 2 2 1 zinc RING finger of MSL2 Rtf2 PF04641.12 CCF34849.1 - 0.0064 15.9 0.0 0.0066 15.8 0.0 1.2 1 0 0 1 1 1 1 Rtf2 RING-finger zf-RING_6 PF14835.6 CCF34849.1 - 0.01 15.7 0.2 0.019 14.8 0.2 1.5 1 0 0 1 1 1 1 zf-RING of BARD1-type protein RINGv PF12906.7 CCF34849.1 - 0.011 15.9 3.3 0.011 15.9 3.3 2.0 2 0 0 2 2 2 0 RING-variant domain zf-RING-like PF08746.11 CCF34849.1 - 0.026 14.8 3.2 0.05 13.9 3.2 1.5 1 0 0 1 1 1 0 RING-like domain zf-RING_4 PF14570.6 CCF34849.1 - 0.052 13.4 1.7 0.086 12.6 0.5 1.8 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-UDP PF14569.6 CCF34849.1 - 0.065 13.4 0.6 0.079 13.1 0.0 1.5 2 0 0 2 2 1 0 Zinc-binding RING-finger zf-C3HC4_4 PF15227.6 CCF34849.1 - 0.15 12.2 8.7 0.63 10.2 3.1 2.7 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-C3H2C3 PF17122.5 CCF34849.1 - 3.1 7.9 9.7 0.74 9.9 5.6 2.0 2 1 0 2 2 2 0 Zinc-finger Ribosomal_L37ae PF01780.19 CCF34850.1 - 1.1e-40 137.6 9.2 1.3e-40 137.4 9.2 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family Zn_Tnp_IS1595 PF12760.7 CCF34850.1 - 0.01 15.8 2.6 0.017 15.1 2.6 1.4 1 0 0 1 1 1 0 Transposase zinc-ribbon domain zf-RING_13 PF17977.1 CCF34850.1 - 0.013 15.6 2.9 0.019 15.1 2.9 1.2 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain C1_2 PF03107.16 CCF34850.1 - 0.024 15.0 2.2 1.3 9.4 0.2 2.1 1 1 1 2 2 2 0 C1 domain DUF1451 PF07295.11 CCF34850.1 - 0.047 13.7 1.3 0.066 13.2 1.3 1.2 1 0 0 1 1 1 0 Zinc-ribbon containing domain Sgf11 PF08209.11 CCF34850.1 - 0.054 13.1 0.3 0.86 9.2 0.0 2.3 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) zf-C2H2 PF00096.26 CCF34850.1 - 4.7 7.9 6.4 8.1 7.1 1.4 2.4 2 0 0 2 2 2 0 Zinc finger, C2H2 type Sacchrp_dh_NADP PF03435.18 CCF34851.1 - 1.7e-14 54.2 0.0 1.2e-13 51.4 0.0 2.1 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain Semialdhyde_dh PF01118.24 CCF34851.1 - 0.08 13.4 0.0 0.13 12.7 0.0 1.3 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.20 CCF34851.1 - 0.18 11.9 0.0 0.28 11.3 0.0 1.3 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus A_deaminase PF00962.22 CCF34852.1 - 0.0029 17.0 0.4 0.032 13.6 0.0 2.0 2 0 0 2 2 2 1 Adenosine/AMP deaminase A_deaminase_N PF08451.11 CCF34852.1 - 0.0047 17.2 0.0 0.015 15.6 0.0 1.8 1 1 0 1 1 1 1 Adenosine/AMP deaminase N-terminal DHDPS PF00701.22 CCF34853.1 - 3.3e-40 137.6 0.0 3.8e-40 137.4 0.0 1.1 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family Sugar_tr PF00083.24 CCF34854.1 - 3.5e-96 322.8 19.0 4e-96 322.6 19.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF34854.1 - 2.1e-20 73.0 16.9 2.1e-20 73.0 16.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_5 PF05631.14 CCF34854.1 - 0.0018 17.3 0.1 0.0018 17.3 0.1 2.7 3 1 1 4 4 4 1 Sugar-tranasporters, 12 TM Fungal_trans_2 PF11951.8 CCF34855.1 - 2e-51 175.1 0.5 2.2e-51 174.9 0.5 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain Pec_lyase_C PF00544.19 CCF34856.1 - 2.4e-42 144.9 5.0 2.9e-42 144.6 4.6 1.3 1 1 0 1 1 1 1 Pectate lyase Beta_helix PF13229.6 CCF34856.1 - 3.7e-07 30.1 14.2 5.9e-05 23.0 3.7 2.2 1 1 1 2 2 2 2 Right handed beta helix region Glycos_transf_3 PF00591.21 CCF34858.1 - 8.9e-63 212.2 0.0 1.5e-62 211.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family, a/b domain Glycos_trans_3N PF02885.17 CCF34858.1 - 4.9e-11 42.3 0.0 1.2e-10 41.1 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferase family, helical bundle domain DAGK_cat PF00781.24 CCF34859.1 - 2.8e-24 85.1 0.0 5.2e-24 84.3 0.0 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain PRKCSH-like PF12999.7 CCF34859.1 - 0.031 14.1 0.0 0.054 13.3 0.0 1.3 1 0 0 1 1 1 0 Glucosidase II beta subunit-like Nop52 PF05997.12 CCF34860.1 - 3.5e-20 72.7 0.0 4.6e-20 72.3 0.0 1.2 1 0 0 1 1 1 1 Nucleolar protein,Nop52 Pectinesterase PF01095.19 CCF34861.1 - 3.3e-139 462.7 59.5 1.5e-43 148.7 4.9 6.2 6 0 0 6 6 6 4 Pectinesterase MFS_1 PF07690.16 CCF34862.1 - 4.4e-08 32.4 32.5 4.4e-07 29.2 33.2 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_1 PF07690.16 CCF34863.1 - 1.1e-37 129.8 58.8 4.4e-37 127.8 57.9 2.2 2 1 0 2 2 2 1 Major Facilitator Superfamily HET PF06985.11 CCF34864.1 - 2e-38 132.0 0.5 3.5e-38 131.2 0.5 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) PUA_3 PF17785.1 CCF34864.1 - 0.067 13.0 0.0 1.4 8.8 0.0 3.1 3 0 0 3 3 3 0 PUA-like domain NO_synthase PF02898.15 CCF34867.1 - 4.4e-92 308.9 0.0 3.1e-90 302.8 0.0 2.1 2 0 0 2 2 2 2 Nitric oxide synthase, oxygenase domain Flavodoxin_1 PF00258.25 CCF34867.1 - 2.7e-10 40.6 0.0 7.3e-10 39.2 0.0 1.8 1 0 0 1 1 1 1 Flavodoxin FAD_binding_1 PF00667.20 CCF34867.1 - 0.00019 21.0 0.0 0.0023 17.5 0.0 2.1 1 1 0 2 2 2 1 FAD binding domain NAD_binding_1 PF00175.21 CCF34867.1 - 0.0059 17.2 0.0 0.014 16.0 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain DUF1707 PF08044.11 CCF34867.1 - 0.17 12.0 1.2 1.6 8.9 0.5 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF1707) Cu-oxidase_3 PF07732.15 CCF34868.1 - 5.7e-44 148.9 2.7 6.7e-44 148.7 0.6 2.3 2 1 1 3 3 3 1 Multicopper oxidase Cu-oxidase PF00394.22 CCF34868.1 - 4.1e-33 114.8 0.0 1.4e-32 113.0 0.0 1.8 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 CCF34868.1 - 3e-07 30.3 1.8 0.014 15.2 0.3 3.8 3 1 0 3 3 3 2 Multicopper oxidase MFS_1 PF07690.16 CCF34870.1 - 3.3e-26 92.1 20.6 4.5e-26 91.6 20.6 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF2776 PF10951.8 CCF34870.1 - 0.44 9.7 5.2 20 4.3 2.6 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF2776) Exo_endo_phos PF03372.23 CCF34871.1 - 1.2e-07 31.5 0.0 2.4e-07 30.5 0.0 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DCP1 PF06058.13 CCF34872.1 - 1.1e-32 112.3 0.0 1.5e-32 111.9 0.0 1.1 1 0 0 1 1 1 1 Dcp1-like decapping family Nramp PF01566.18 CCF34875.1 - 7.7e-16 58.0 0.2 7.7e-16 58.0 0.2 1.9 2 0 0 2 2 2 1 Natural resistance-associated macrophage protein Ribonuc_L-PSP PF01042.21 CCF34876.1 - 1.1e-20 73.8 0.0 1.3e-20 73.6 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP DUF1035 PF06281.12 CCF34877.1 - 0.13 12.3 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1035) Zn_clus PF00172.18 CCF34878.1 - 5.9e-08 32.7 13.5 9.1e-08 32.1 13.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CCF34878.1 - 1.1e-07 31.1 0.0 1.6e-07 30.6 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain DSBA PF01323.20 CCF34878.1 - 0.014 15.2 0.0 0.025 14.4 0.0 1.4 1 0 0 1 1 1 0 DSBA-like thioredoxin domain OrfB_Zn_ribbon PF07282.11 CCF34878.1 - 0.32 10.9 6.3 0.62 10.0 6.3 1.5 1 0 0 1 1 1 0 Putative transposase DNA-binding domain Sugar_tr PF00083.24 CCF34880.1 - 6.1e-67 226.4 29.6 7.4e-67 226.2 29.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF34880.1 - 1.4e-21 76.8 33.9 1.4e-21 76.8 33.9 2.3 1 1 2 3 3 3 1 Major Facilitator Superfamily MFS_2 PF13347.6 CCF34880.1 - 0.017 13.7 35.8 0.062 11.8 10.2 2.8 2 1 0 2 2 2 0 MFS/sugar transport protein AA_permease_C PF13906.6 CCF34880.1 - 1.1 9.4 12.3 0.18 11.9 0.8 3.5 3 0 0 3 3 3 0 C-terminus of AA_permease Abhydrolase_3 PF07859.13 CCF34881.1 - 9.8e-17 61.5 0.0 1.1e-10 41.7 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CCF34881.1 - 1.3e-10 41.1 0.0 4.4e-07 29.6 0.0 2.3 2 0 0 2 2 2 2 Prolyl oligopeptidase family COesterase PF00135.28 CCF34881.1 - 3.9e-06 26.0 0.0 9.4e-06 24.8 0.0 1.5 2 0 0 2 2 2 1 Carboxylesterase family Peptidase_S15 PF02129.18 CCF34881.1 - 7.1e-05 22.5 0.0 0.00071 19.2 0.0 2.4 1 1 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) DLH PF01738.18 CCF34881.1 - 0.0023 17.5 0.0 0.0095 15.5 0.0 1.9 3 0 0 3 3 3 1 Dienelactone hydrolase family Esterase_phd PF10503.9 CCF34881.1 - 0.0052 16.3 0.1 7.4 6.0 0.0 3.0 3 0 0 3 3 3 1 Esterase PHB depolymerase Hydrolase_4 PF12146.8 CCF34881.1 - 0.013 14.8 0.1 0.63 9.3 0.0 2.4 2 1 1 3 3 3 0 Serine aminopeptidase, S33 Abhydrolase_2 PF02230.16 CCF34881.1 - 0.014 15.2 0.0 2.5 7.8 0.0 2.6 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase Abhydrolase_1 PF00561.20 CCF34881.1 - 0.016 14.9 0.6 1.8 8.1 0.0 2.7 2 1 0 2 2 2 0 alpha/beta hydrolase fold AXE1 PF05448.12 CCF34881.1 - 0.071 11.8 0.0 0.42 9.2 0.0 2.0 2 0 0 2 2 2 0 Acetyl xylan esterase (AXE1) Glyco_hydro_43 PF04616.14 CCF34883.1 - 2.6e-72 243.6 2.6 3.4e-72 243.2 2.6 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 GH43_C2 PF17851.1 CCF34883.1 - 5.3e-10 39.4 0.0 8.2e-10 38.7 0.0 1.2 1 0 0 1 1 1 1 Beta xylosidase C-terminal Concanavalin A-like domain Glyco_hydro_32N PF00251.20 CCF34883.1 - 0.02 14.5 1.5 0.02 14.5 0.0 1.7 2 0 0 2 2 2 0 Glycosyl hydrolases family 32 N-terminal domain DUF5005 PF16396.5 CCF34883.1 - 0.11 11.2 0.0 0.66 8.6 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5005) Spc7 PF08317.11 CCF34886.1 - 0.00029 19.8 23.0 0.0018 17.2 4.6 2.5 3 0 0 3 3 3 2 Spc7 kinetochore protein IFT20 PF14931.6 CCF34886.1 - 0.021 15.0 7.0 0.021 15.0 7.0 2.7 2 1 0 2 2 2 0 Intraflagellar transport complex B, subunit 20 CorA PF01544.18 CCF34886.1 - 0.021 14.1 7.2 0.022 14.1 6.6 1.4 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein BLOC1_2 PF10046.9 CCF34886.1 - 0.028 14.7 3.9 0.028 14.7 3.9 3.6 4 1 1 5 5 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 OmpH PF03938.14 CCF34886.1 - 0.03 14.7 34.3 0.2 12.0 5.7 3.1 1 1 2 3 3 3 0 Outer membrane protein (OmpH-like) NPV_P10 PF05531.12 CCF34886.1 - 0.035 14.6 8.8 0.053 14.0 0.6 2.8 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DASH_Dam1 PF08653.10 CCF34886.1 - 0.093 12.5 5.0 1.1 9.1 0.0 3.7 4 1 0 4 4 4 0 DASH complex subunit Dam1 GAS PF13851.6 CCF34886.1 - 0.38 10.1 28.4 0.055 12.8 7.0 3.2 3 0 0 3 3 3 0 Growth-arrest specific micro-tubule binding ATF7IP_BD PF16788.5 CCF34886.1 - 0.39 10.8 11.1 0.09 12.9 5.9 2.2 2 1 0 2 2 2 0 ATF-interacting protein binding domain Fez1 PF06818.15 CCF34886.1 - 0.41 11.1 26.2 0.078 13.4 20.3 2.3 2 1 1 3 3 3 0 Fez1 Laminin_II PF06009.12 CCF34886.1 - 0.49 10.4 17.8 0.19 11.8 2.2 3.1 3 0 0 3 3 3 0 Laminin Domain II DUF3037 PF11236.8 CCF34886.1 - 0.7 10.3 6.1 1.4 9.3 1.2 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3037) HIP1_clath_bdg PF16515.5 CCF34886.1 - 0.8 10.4 25.2 0.81 10.3 7.2 3.0 3 0 0 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Spc24 PF08286.11 CCF34886.1 - 1 9.6 20.6 0.037 14.3 3.9 3.7 3 1 0 3 3 3 0 Spc24 subunit of Ndc80 DUF4407 PF14362.6 CCF34886.1 - 1.5 8.1 24.3 14 4.9 24.2 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) PAXX PF15384.6 CCF34886.1 - 1.6 8.4 12.3 1.1 8.9 0.9 2.8 1 1 1 2 2 2 0 PAXX, PAralog of XRCC4 and XLF, also called C9orf142 MPS2 PF17060.5 CCF34886.1 - 2.2 7.4 15.4 0.8 8.9 11.5 2.0 1 1 0 2 2 2 0 Monopolar spindle protein 2 FapA PF03961.13 CCF34886.1 - 2.4 6.6 16.2 2.6 6.6 4.0 2.2 1 1 0 2 2 2 0 Flagellar Assembly Protein A DUF848 PF05852.11 CCF34886.1 - 2.4 8.2 18.0 0.046 13.8 2.9 2.8 2 1 1 3 3 3 0 Gammaherpesvirus protein of unknown function (DUF848) DUF1664 PF07889.12 CCF34886.1 - 3 7.9 8.4 5.7 7.0 0.6 2.6 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) DUF948 PF06103.11 CCF34886.1 - 3.3 8.0 9.9 0.41 10.9 1.7 2.6 3 0 0 3 3 2 0 Bacterial protein of unknown function (DUF948) DUF2730 PF10805.8 CCF34886.1 - 3.5 7.8 12.4 5.7 7.1 1.3 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF2730) ATG16 PF08614.11 CCF34886.1 - 3.9 7.7 31.4 0.39 10.9 5.8 3.2 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) PRKG1_interact PF15898.5 CCF34886.1 - 5 8.1 28.5 3.2 8.7 9.1 3.1 3 0 0 3 3 3 0 cGMP-dependent protein kinase interacting domain FemAB PF02388.16 CCF34886.1 - 5.3 5.8 17.2 0.089 11.7 5.4 2.3 1 1 1 2 2 2 0 FemAB family YlqD PF11068.8 CCF34886.1 - 6.5 7.1 23.3 1 9.7 6.3 2.9 3 0 0 3 3 3 0 YlqD protein Vps5 PF09325.10 CCF34886.1 - 7.2 6.1 14.4 1.4 8.4 2.0 2.5 2 0 0 2 2 2 0 Vps5 C terminal like AAA_13 PF13166.6 CCF34886.1 - 7.6 5.0 18.5 18 3.8 18.5 1.8 1 1 0 1 1 1 0 AAA domain Atg14 PF10186.9 CCF34886.1 - 8.9 5.3 23.7 0.51 9.4 4.5 2.5 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Ribosomal_L37e PF01907.19 CCF34887.1 - 8.9e-28 96.2 13.3 1.3e-27 95.7 13.3 1.2 1 0 0 1 1 1 1 Ribosomal protein L37e DZR PF12773.7 CCF34887.1 - 0.01 15.9 1.5 0.015 15.3 1.5 1.3 1 0 0 1 1 1 0 Double zinc ribbon zinc_ribbon_2 PF13240.6 CCF34887.1 - 0.11 12.3 2.4 7 6.5 0.3 2.2 2 0 0 2 2 2 0 zinc-ribbon domain HypA PF01155.19 CCF34887.1 - 0.15 12.1 1.0 0.19 11.7 1.0 1.2 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Rubredoxin_2 PF18073.1 CCF34887.1 - 0.19 11.5 3.0 2.5 7.9 0.4 2.3 2 0 0 2 2 2 0 Rubredoxin metal binding domain zn-ribbon_14 PF16503.5 CCF34887.1 - 1 8.9 5.8 1.4 8.5 0.6 2.2 2 0 0 2 2 2 0 Zinc-ribbon ELP6 PF09807.9 CCF34888.1 - 2.1e-12 47.0 0.0 3e-12 46.5 0.0 1.2 1 0 0 1 1 1 1 Elongation complex protein 6 ATPase PF06745.13 CCF34888.1 - 0.01 15.2 0.0 0.013 14.9 0.0 1.1 1 0 0 1 1 1 0 KaiC MFS_1 PF07690.16 CCF34890.1 - 8.2e-38 130.2 27.1 8.2e-38 130.2 27.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF34890.1 - 1.4e-10 40.6 10.7 1.4e-10 40.6 10.7 2.3 3 0 0 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.13 CCF34890.1 - 5.6e-06 25.1 4.8 1.2e-05 23.9 4.8 1.5 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_3 PF05977.13 CCF34890.1 - 0.00014 20.4 0.6 0.00014 20.4 0.6 2.1 2 0 0 2 2 2 1 Transmembrane secretion effector Aminotran_3 PF00202.21 CCF34891.1 - 6.2e-50 170.0 0.0 1.5e-26 93.0 0.0 2.0 2 0 0 2 2 2 2 Aminotransferase class-III Aminotran_5 PF00266.19 CCF34891.1 - 0.12 11.4 0.0 1.5 7.7 0.0 2.0 2 0 0 2 2 2 0 Aminotransferase class-V Asparaginase_2 PF01112.18 CCF34892.1 - 3.3e-73 246.4 5.7 4.2e-73 246.0 5.7 1.0 1 0 0 1 1 1 1 Asparaginase Bac_rhamnosid6H PF17389.2 CCF34894.1 - 1.5e-16 60.6 0.1 1.5e-15 57.3 0.1 2.0 1 1 0 1 1 1 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Cytomega_UL20A PF05984.12 CCF34895.1 - 0.0036 17.6 0.1 0.0049 17.2 0.1 1.4 1 1 0 1 1 1 1 Cytomegalovirus UL20A protein SR-25 PF10500.9 CCF34896.1 - 0.041 13.5 2.9 0.059 13.0 2.9 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein HisKA_7TM PF16927.5 CCF34896.1 - 0.057 13.4 1.4 0.082 12.9 1.4 1.2 1 0 0 1 1 1 0 N-terminal 7TM region of histidine kinase PUL PF08324.11 CCF34897.1 - 6.9e-68 228.9 0.1 1e-67 228.3 0.1 1.3 1 0 0 1 1 1 1 PUL domain PFU PF09070.11 CCF34897.1 - 5.1e-45 152.4 0.2 9.9e-45 151.4 0.2 1.5 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) WD40 PF00400.32 CCF34897.1 - 4e-33 112.9 2.4 6.2e-07 30.0 0.0 7.6 7 0 0 7 7 7 5 WD domain, G-beta repeat WD40_like PF17005.5 CCF34897.1 - 0.036 13.4 0.0 0.072 12.4 0.0 1.5 1 1 0 1 1 1 0 WD40-like domain BBS2_Mid PF14783.6 CCF34897.1 - 0.082 13.0 0.0 5.7 7.0 0.0 3.0 2 1 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region WD40 PF00400.32 CCF34898.1 - 1e-22 80.0 4.7 7.1e-08 33.0 0.1 5.2 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF34898.1 - 0.00041 20.6 0.0 1.8 8.9 0.0 3.6 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CCF34898.1 - 0.0042 16.1 0.0 0.68 8.8 0.0 2.2 2 0 0 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Glyco_hydro_64 PF16483.5 CCF34900.1 - 1.3e-129 432.7 0.0 1.5e-129 432.5 0.0 1.0 1 0 0 1 1 1 1 Beta-1,3-glucanase Glyco_hydro_16 PF00722.21 CCF34901.1 - 1.5e-15 57.1 0.0 2.4e-15 56.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Syndecan PF01034.20 CCF34904.1 - 0.01 15.7 0.0 0.023 14.6 0.0 1.5 1 0 0 1 1 1 0 Syndecan domain EphA2_TM PF14575.6 CCF34904.1 - 0.15 12.9 0.0 0.47 11.4 0.0 1.8 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Gram_pos_anchor PF00746.21 CCF34904.1 - 0.38 10.7 1.4 0.73 9.8 1.4 1.5 1 0 0 1 1 1 0 LPXTG cell wall anchor motif SKG6 PF08693.10 CCF34904.1 - 2.2 7.8 6.8 3.6 7.1 6.8 1.3 1 0 0 1 1 1 0 Transmembrane alpha-helix domain DUF2273 PF10031.9 CCF34904.1 - 2.3 8.3 7.5 3.9 7.6 7.5 1.3 1 0 0 1 1 1 0 Small integral membrane protein (DUF2273) DUF4637 PF15470.6 CCF34905.1 - 1 9.1 3.8 3.1 7.5 2.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) Pyridoxal_deC PF00282.19 CCF34910.1 - 2.7e-14 52.7 0.0 4.5e-14 52.0 0.0 1.4 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 CCF34910.1 - 9.6e-06 24.8 0.0 2.9e-05 23.2 0.0 1.8 1 1 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 CCF34910.1 - 0.061 12.6 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family AICARFT_IMPCHas PF01808.18 CCF34912.1 - 1.8e-92 309.9 0.0 2.4e-92 309.6 0.0 1.1 1 0 0 1 1 1 1 AICARFT/IMPCHase bienzyme MGS PF02142.22 CCF34912.1 - 4.5e-13 49.2 0.1 8.8e-13 48.3 0.1 1.5 1 0 0 1 1 1 1 MGS-like domain zf-H2C2_2 PF13465.6 CCF34913.1 - 1.4e-24 85.3 33.0 2.3e-08 34.1 0.0 7.3 7 0 0 7 7 7 4 Zinc-finger double domain zf-C2H2 PF00096.26 CCF34913.1 - 3e-16 58.9 46.8 0.00034 20.9 0.4 8.4 8 0 0 8 8 7 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCF34913.1 - 1.3e-12 47.4 43.7 0.011 16.6 0.3 8.5 8 0 0 8 8 7 6 C2H2-type zinc finger zf-C2H2_6 PF13912.6 CCF34913.1 - 2.6e-06 27.3 32.3 0.053 13.5 1.3 6.3 6 0 0 6 6 6 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CCF34913.1 - 7.6e-05 22.9 21.8 0.23 11.8 2.5 6.1 5 0 0 5 5 5 2 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.5 CCF34913.1 - 0.011 15.4 0.3 0.011 15.4 0.3 5.8 6 0 0 6 6 6 0 zinc-finger C2H2-type zf-C2H2_9 PF16293.5 CCF34913.1 - 0.047 13.5 5.7 11 6.0 0.1 4.4 4 0 0 4 4 4 0 C2H2 type zinc-finger (1 copy) zf-H2C2_5 PF13909.6 CCF34913.1 - 0.11 12.2 34.4 0.13 12.0 0.9 6.7 6 0 0 6 6 6 0 C2H2-type zinc-finger domain zf-C2H2_aberr PF17017.5 CCF34913.1 - 0.47 10.6 4.9 6.9 6.8 0.4 3.1 2 1 0 3 3 3 0 Aberrant zinc-finger FOXP-CC PF16159.5 CCF34913.1 - 0.87 10.3 23.8 0.47 11.1 0.3 5.5 3 2 2 5 5 5 0 FOXP coiled-coil domain zf-met PF12874.7 CCF34913.1 - 4.3 7.9 16.7 22 5.6 0.2 6.5 6 0 0 6 6 6 0 Zinc-finger of C2H2 type PTCB-BRCT PF12738.7 CCF34915.1 - 0.11 12.5 0.1 12 6.0 0.1 2.4 2 0 0 2 2 2 0 twin BRCT domain AT_hook PF02178.19 CCF34915.1 - 0.18 11.8 11.8 0.45 10.6 0.4 4.2 3 0 0 3 3 3 0 AT hook motif Glyco_hyd_65N_2 PF14498.6 CCF34916.1 - 1.6e-11 44.6 0.0 1.8e-11 44.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain CVNH PF08881.10 CCF34917.1 - 3.3e-14 53.4 0.1 4.8e-14 52.9 0.1 1.3 1 0 0 1 1 1 1 CVNH domain DUF4723 PF15851.5 CCF34917.1 - 0.02 15.0 3.3 0.054 13.6 1.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4723) zf-TFIIIC PF12660.7 CCF34918.1 - 3.8e-11 42.8 1.4 6.4e-11 42.1 1.4 1.4 1 0 0 1 1 1 1 Putative zinc-finger of transcription factor IIIC complex DUF2890 PF11081.8 CCF34919.1 - 0.74 9.9 2.7 0.7 10.0 2.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) Adaptin_N PF01602.20 CCF34920.1 - 1.6e-121 406.4 9.6 2e-121 406.1 9.6 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 CCF34920.1 - 9e-56 188.4 8.4 5.5e-55 185.8 0.1 3.8 3 1 1 4 4 4 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 CCF34920.1 - 1.7e-15 57.2 5.3 5.4e-05 23.5 0.1 4.7 4 1 1 5 5 5 4 HEAT repeats HEAT PF02985.22 CCF34920.1 - 2.1e-10 39.9 4.3 0.00065 19.8 0.0 5.4 6 0 0 6 6 6 3 HEAT repeat CLASP_N PF12348.8 CCF34920.1 - 9.6e-05 22.0 0.2 0.037 13.6 0.0 2.7 2 0 0 2 2 2 2 CLASP N terminal HEAT_EZ PF13513.6 CCF34920.1 - 0.00082 19.8 3.2 35 5.0 0.0 5.9 6 0 0 6 6 6 0 HEAT-like repeat Atx10homo_assoc PF09759.9 CCF34920.1 - 0.0015 18.5 0.0 19 5.4 0.0 4.8 4 1 1 5 5 5 1 Spinocerebellar ataxia type 10 protein domain RTP1_C1 PF10363.9 CCF34920.1 - 0.0026 17.9 1.5 0.42 10.8 0.0 3.5 2 1 1 3 3 3 1 Required for nuclear transport of RNA pol II C-terminus 1 Arm PF00514.23 CCF34920.1 - 0.19 11.9 2.9 4.6 7.4 0.0 4.2 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat DUF1077 PF06417.12 CCF34921.1 - 1.5e-49 166.9 5.6 2.2e-49 166.4 5.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) CCDC14 PF15254.6 CCF34921.1 - 0.074 11.7 0.3 0.097 11.3 0.3 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 14 HET PF06985.11 CCF34923.1 - 3.3e-27 95.6 0.0 5.2e-27 95.0 0.0 1.3 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Corona_nucleoca PF00937.18 CCF34924.1 - 0.48 9.4 4.4 0.61 9.1 4.4 1.2 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein SH3BGR PF04908.15 CCF34925.1 - 2.3e-05 24.5 0.0 7.8e-05 22.8 0.0 2.0 1 1 1 2 2 2 1 SH3-binding, glutamic acid-rich protein Lipase_GDSL_2 PF13472.6 CCF34927.1 - 1.6e-17 64.5 0.2 2.2e-17 64.0 0.2 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 CCF34927.1 - 1.3e-09 38.3 0.0 1.6e-09 38.0 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_3 PF14606.6 CCF34927.1 - 0.0017 18.5 0.0 0.0026 17.9 0.0 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Rax2 PF12768.7 CCF34929.1 - 0.083 12.3 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 Cortical protein marker for cell polarity DUF1168 PF06658.12 CCF34930.1 - 0.035 13.9 0.2 0.062 13.1 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1168) His_Phos_1 PF00300.22 CCF34931.1 - 1.9e-26 92.9 0.0 3.7e-26 92.0 0.0 1.5 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) His_Phos_2 PF00328.22 CCF34931.1 - 0.05 12.9 0.0 0.082 12.2 0.0 1.2 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 2) Transket_pyr PF02779.24 CCF34932.1 - 3.6e-62 209.2 0.0 6.5e-62 208.3 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.20 CCF34932.1 - 7.2e-57 192.6 0.0 9.8e-57 192.2 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component OxoGdeHyase_C PF16870.5 CCF34932.1 - 1.9e-55 186.7 0.0 3.4e-55 185.9 0.0 1.4 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal 2-oxogl_dehyd_N PF16078.5 CCF34932.1 - 7e-20 70.3 1.3 1.5e-19 69.3 1.3 1.6 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase N-terminus baeRF_family12 PF18856.1 CCF34932.1 - 0.089 13.4 0.3 0.31 11.6 0.0 2.0 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 12 YceG_bac PF14266.6 CCF34932.1 - 0.21 10.5 0.1 0.33 9.8 0.1 1.2 1 0 0 1 1 1 0 Putative component of 'biosynthetic module' BioY PF02632.14 CCF34932.1 - 0.21 11.6 0.2 0.36 10.9 0.2 1.2 1 0 0 1 1 1 0 BioY family WW PF00397.26 CCF34933.1 - 4.2e-10 39.5 0.3 1.2e-09 38.1 0.3 1.8 1 0 0 1 1 1 1 WW domain Pga1 PF10333.9 CCF34934.1 - 1.5e-05 24.9 0.7 0.00015 21.7 0.7 2.4 1 1 0 1 1 1 1 GPI-Mannosyltransferase II co-activator PAP2 PF01569.21 CCF34934.1 - 0.11 12.2 0.6 0.19 11.5 0.0 1.8 2 0 0 2 2 2 0 PAP2 superfamily Tubulin PF00091.25 CCF34935.1 - 1.4e-66 224.5 0.0 2.1e-66 223.9 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 CCF34935.1 - 7.8e-50 168.3 0.1 1.3e-49 167.5 0.1 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 CCF34935.1 - 0.003 17.2 0.0 0.0074 16.0 0.0 1.7 2 0 0 2 2 2 1 Tubulin domain p450 PF00067.22 CCF34936.1 - 3e-30 105.4 0.0 3.7e-30 105.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 BatA PF07584.11 CCF34936.1 - 0.2 12.0 3.6 24 5.4 2.7 2.5 2 0 0 2 2 2 0 Aerotolerance regulator N-terminal DUF4118 PF13493.6 CCF34936.1 - 0.88 9.4 4.3 1.8 8.4 4.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4118) DIT1_PvcA PF05141.12 CCF34937.1 - 6.9e-104 347.2 0.0 8.6e-104 346.9 0.0 1.1 1 0 0 1 1 1 1 Pyoverdine/dityrosine biosynthesis protein Pertussis_S2S3 PF02918.15 CCF34937.1 - 0.076 12.9 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 Pertussis toxin, subunit 2 and 3, C-terminal domain GMC_oxred_N PF00732.19 CCF34938.1 - 6.4e-56 189.9 0.0 8.4e-56 189.5 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCF34938.1 - 1.3e-37 129.6 0.2 2.1e-37 128.8 0.2 1.4 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.12 CCF34938.1 - 9e-05 21.7 0.1 0.00014 21.1 0.1 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_binding_2 PF00890.24 CCF34938.1 - 0.0001 21.5 0.2 0.038 13.1 0.5 2.2 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_3 PF13738.6 CCF34938.1 - 0.00028 20.2 0.0 0.079 12.2 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CCF34938.1 - 0.00038 19.8 0.1 0.0021 17.3 0.1 2.0 2 0 0 2 2 2 1 Thi4 family NAD_binding_8 PF13450.6 CCF34938.1 - 0.00049 20.3 0.6 0.0013 18.9 0.6 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CCF34938.1 - 0.0005 19.4 0.2 0.0016 17.7 0.1 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCF34938.1 - 0.0016 18.1 0.6 0.0083 15.8 0.5 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 CCF34938.1 - 0.048 13.7 0.2 0.12 12.3 0.2 1.8 1 1 0 1 1 1 0 FAD-NAD(P)-binding HI0933_like PF03486.14 CCF34938.1 - 0.051 12.3 0.1 0.077 11.7 0.1 1.2 1 0 0 1 1 1 0 HI0933-like protein Trp_halogenase PF04820.14 CCF34938.1 - 0.068 12.0 0.3 0.12 11.2 0.3 1.4 1 0 0 1 1 1 0 Tryptophan halogenase WSC PF01822.19 CCF34940.1 - 1.4e-09 38.0 1.7 1.4e-09 38.0 1.7 3.0 2 1 0 2 2 2 1 WSC domain CPSase_L_D2 PF02786.17 CCF34941.1 - 3.3e-112 373.1 0.2 1.4e-83 279.5 0.0 2.2 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_sm_chain PF00988.22 CCF34941.1 - 3.2e-46 156.3 0.0 8.2e-46 155.0 0.0 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.28 CCF34941.1 - 1e-45 155.9 0.0 2.2e-45 154.8 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase class-I CPSase_L_D3 PF02787.19 CCF34941.1 - 2.3e-40 137.7 0.1 5.8e-40 136.4 0.1 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain MGS PF02142.22 CCF34941.1 - 9.6e-22 77.0 0.0 4e-21 75.0 0.0 2.1 2 0 0 2 2 2 1 MGS-like domain Dala_Dala_lig_C PF07478.13 CCF34941.1 - 2.3e-17 63.2 0.4 1.7e-08 34.3 0.1 2.4 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus OTCace_N PF02729.21 CCF34941.1 - 4.4e-16 59.2 0.1 1.1e-15 58.0 0.1 1.7 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain ATP-grasp PF02222.22 CCF34941.1 - 5.4e-16 58.6 0.1 5.1e-08 32.7 0.1 2.4 2 0 0 2 2 2 2 ATP-grasp domain ATPgrasp_Ter PF15632.6 CCF34941.1 - 1.1e-09 38.1 0.0 0.0001 22.0 0.0 2.7 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_3 PF02655.14 CCF34941.1 - 6.5e-06 26.3 0.4 0.028 14.4 0.1 2.8 2 0 0 2 2 2 2 ATP-grasp domain Peptidase_C26 PF07722.13 CCF34941.1 - 6.8e-06 26.0 0.6 0.00071 19.4 0.1 3.0 2 1 0 2 2 2 1 Peptidase C26 DJ-1_PfpI PF01965.24 CCF34941.1 - 1.7e-05 24.7 0.1 0.024 14.5 0.0 3.7 3 0 0 3 3 3 1 DJ-1/PfpI family GARS_A PF01071.19 CCF34941.1 - 0.0076 16.0 0.5 4.1 7.1 0.1 3.0 3 0 0 3 3 3 2 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Glyco_hydro_17 PF00332.18 CCF34942.1 - 1.1e-08 35.1 3.9 0.0014 18.3 0.5 2.2 1 1 1 2 2 2 2 Glycosyl hydrolases family 17 SNARE PF05739.19 CCF34942.1 - 0.44 10.6 2.0 0.8 9.8 2.0 1.4 1 0 0 1 1 1 0 SNARE domain Ribosomal_S24e PF01282.19 CCF34943.1 - 1.2e-34 118.1 0.1 2.2e-34 117.2 0.0 1.5 1 1 0 1 1 1 1 Ribosomal protein S24e Methyltransf_16 PF10294.9 CCF34944.1 - 2e-20 73.3 0.0 3.1e-20 72.6 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase MTS PF05175.14 CCF34944.1 - 0.0005 19.7 0.0 0.00079 19.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 CCF34944.1 - 0.00093 19.9 0.0 0.0019 18.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain DUF938 PF06080.12 CCF34944.1 - 0.0023 17.7 0.0 0.0036 17.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF938) Methyltransf_23 PF13489.6 CCF34944.1 - 0.003 17.4 0.0 0.0046 16.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 CCF34944.1 - 0.0036 17.1 0.2 0.015 15.1 0.1 2.0 1 1 1 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Met_10 PF02475.16 CCF34944.1 - 0.0077 16.0 0.0 0.011 15.5 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein PrmA PF06325.13 CCF34944.1 - 0.011 15.2 0.1 0.016 14.6 0.1 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_12 PF08242.12 CCF34944.1 - 0.011 16.4 0.0 0.022 15.5 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 CCF34944.1 - 0.056 13.2 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_3 PF01596.17 CCF34944.1 - 0.067 12.4 0.0 0.1 11.8 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase Methyltransf_18 PF12847.7 CCF34944.1 - 0.15 12.0 0.0 0.31 10.9 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Whi5 PF08528.11 CCF34946.1 - 1.3e-10 40.6 0.2 2.2e-10 39.9 0.2 1.4 1 0 0 1 1 1 1 Whi5 like HEM4 PF02602.15 CCF34947.1 - 1.1e-41 142.7 0.0 1.4e-41 142.3 0.0 1.1 1 0 0 1 1 1 1 Uroporphyrinogen-III synthase HemD Cupin_2 PF07883.11 CCF34947.1 - 0.11 12.2 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 Cupin domain Evr1_Alr PF04777.13 CCF34948.1 - 4.5e-32 110.5 0.7 1.9e-31 108.5 0.8 1.8 2 0 0 2 2 2 1 Erv1 / Alr family DDE_Tnp_ISL3 PF01610.17 CCF34948.1 - 0.19 11.4 0.1 0.23 11.2 0.1 1.1 1 0 0 1 1 1 0 Transposase HNH_2 PF13391.6 CCF34950.1 - 0.00021 21.3 0.0 0.0004 20.5 0.0 1.5 1 0 0 1 1 1 1 HNH endonuclease Syja_N PF02383.18 CCF34951.1 - 4.7e-87 292.3 0.0 5.9e-87 292.0 0.0 1.1 1 0 0 1 1 1 1 SacI homology domain Glyco_hydro_76 PF03663.14 CCF34952.1 - 2.9e-123 412.0 11.3 3.5e-123 411.8 11.3 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 BCS1_N PF08740.11 CCF34953.1 - 3.9e-34 118.3 2.4 1.3e-33 116.6 0.1 2.3 2 0 0 2 2 2 1 BCS1 N terminal AAA PF00004.29 CCF34953.1 - 9.4e-18 64.9 0.0 7.8e-17 61.9 0.0 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 CCF34953.1 - 5.1e-05 23.1 0.0 9.1e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_11 PF13086.6 CCF34953.1 - 0.0005 19.9 2.8 0.14 11.9 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 CCF34953.1 - 0.026 14.9 0.1 0.084 13.3 0.1 1.9 1 1 0 1 1 1 0 AAA ATPase domain ATPase PF06745.13 CCF34953.1 - 0.081 12.3 0.1 0.26 10.6 0.0 1.8 2 0 0 2 2 2 0 KaiC SWIRM-assoc_2 PF16496.5 CCF34953.1 - 0.18 10.7 8.9 0.34 9.7 8.9 1.4 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal Hydin_ADK PF17213.3 CCF34953.1 - 0.73 10.1 8.4 4.3 7.6 0.0 2.4 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain SAGA-Tad1 PF12767.7 CCF34953.1 - 6.9 6.3 9.2 15 5.3 9.2 1.5 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit p450 PF00067.22 CCF34954.1 - 3.1e-78 263.6 0.0 4e-78 263.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Glyoxalase PF00903.25 CCF34955.1 - 8.6e-11 42.1 0.0 1.4e-10 41.4 0.0 1.4 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily CppA_N PF14506.6 CCF34955.1 - 0.0009 19.3 0.0 0.0013 18.8 0.0 1.3 1 0 0 1 1 1 1 CppA N-terminal ABC2_membrane PF01061.24 CCF34956.1 - 7e-95 316.4 54.4 1.3e-49 168.4 19.7 3.4 4 0 0 4 4 4 2 ABC-2 type transporter ABC_tran PF00005.27 CCF34956.1 - 1e-34 120.0 0.0 4.5e-16 59.6 0.0 3.4 3 0 0 3 3 3 2 ABC transporter PDR_CDR PF06422.12 CCF34956.1 - 5.4e-34 116.0 12.4 3.7e-32 110.1 0.0 3.6 4 0 0 4 4 3 2 CDR ABC transporter ABC_trans_N PF14510.6 CCF34956.1 - 1.1e-17 64.4 0.6 5e-17 62.3 0.6 2.3 1 1 0 1 1 1 1 ABC-transporter N-terminal RsgA_GTPase PF03193.16 CCF34956.1 - 5.2e-06 26.5 0.1 0.0011 18.9 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 CCF34956.1 - 5.9e-06 26.8 1.3 0.0025 18.2 0.1 2.8 3 0 0 3 3 2 1 AAA ATPase domain AAA_25 PF13481.6 CCF34956.1 - 3.9e-05 23.3 0.1 0.003 17.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_21 PF13304.6 CCF34956.1 - 0.00012 22.0 0.0 1.2 8.9 0.0 3.2 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CCF34956.1 - 0.0003 20.5 1.1 0.034 13.9 0.2 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_33 PF13671.6 CCF34956.1 - 0.00084 19.5 0.0 0.26 11.4 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 CCF34956.1 - 0.0011 19.5 0.0 0.16 12.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 CCF34956.1 - 0.0038 17.5 0.3 0.86 9.9 0.1 2.7 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 CCF34956.1 - 0.0049 16.5 0.5 0.12 12.0 0.0 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain SMC_N PF02463.19 CCF34956.1 - 0.005 16.3 0.0 2.1 7.7 0.0 3.5 3 1 0 3 3 3 1 RecF/RecN/SMC N terminal domain NACHT PF05729.12 CCF34956.1 - 0.011 15.7 0.0 2 8.3 0.0 2.6 2 0 0 2 2 2 0 NACHT domain AAA_30 PF13604.6 CCF34956.1 - 0.012 15.3 0.2 4.9 6.8 0.1 2.4 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.6 CCF34956.1 - 0.036 14.5 0.3 6.4 7.2 0.0 2.9 2 1 0 2 2 2 0 AAA domain HalX PF08663.10 CCF34956.1 - 0.061 13.7 0.5 14 6.1 0.3 2.4 2 0 0 2 2 2 0 HalX domain AAA_23 PF13476.6 CCF34956.1 - 0.068 13.7 0.7 0.2 12.1 0.1 2.0 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 CCF34956.1 - 0.099 13.1 0.0 13 6.2 0.0 2.5 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.6 CCF34956.1 - 0.1 12.9 1.1 2.2 8.6 0.0 2.8 2 1 0 2 2 2 0 AAA domain AAA_28 PF13521.6 CCF34956.1 - 0.16 12.2 0.2 1.8 8.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 CCF34956.1 - 0.2 11.4 0.8 11 5.7 0.1 2.4 2 0 0 2 2 2 0 AAA domain ECF-ribofla_trS PF07155.12 CCF34956.1 - 1.2 9.1 11.9 0.11 12.4 0.2 3.3 3 0 0 3 3 3 0 ECF-type riboflavin transporter, S component ABC2_membrane_3 PF12698.7 CCF34956.1 - 3.4 6.7 50.6 9.3 5.3 15.7 3.9 3 2 0 3 3 3 0 ABC-2 family transporter protein RVT_2 PF07727.14 CCF34958.1 - 0.17 11.5 0.0 0.28 10.8 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Helicase_C PF00271.31 CCF34961.1 - 9.9e-06 25.9 0.0 1.8e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 CCF34961.1 - 3.5e-05 22.7 0.0 0.0084 14.9 0.0 2.2 2 0 0 2 2 2 2 SNF2 family N-terminal domain DUF1290 PF06947.12 CCF34963.1 - 0.0054 16.8 0.0 0.0059 16.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1290) Peptidase_S64 PF08192.11 CCF34964.1 - 0.00026 19.6 0.0 0.00044 18.9 0.0 1.3 1 1 0 1 1 1 1 Peptidase family S64 Trypsin_2 PF13365.6 CCF34964.1 - 0.00039 21.3 0.2 0.0072 17.2 0.2 2.4 1 1 0 1 1 1 1 Trypsin-like peptidase domain SNF2_N PF00176.23 CCF34966.1 - 2.7e-66 223.7 0.4 4.3e-66 223.0 0.4 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CCF34966.1 - 1.8e-18 66.9 0.0 1.1e-17 64.4 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCF34966.1 - 6.1e-09 36.1 0.0 1.2e-08 35.1 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HSA PF07529.13 CCF34966.1 - 3.2e-05 24.2 6.3 3.2e-05 24.2 6.3 2.7 2 1 0 2 2 2 1 HSA HDA2-3 PF11496.8 CCF34966.1 - 0.012 14.8 0.1 0.98 8.5 0.0 2.6 2 1 0 2 2 2 0 Class II histone deacetylase complex subunits 2 and 3 NDUF_B8 PF05821.11 CCF34967.1 - 1e-08 35.2 0.5 2e-08 34.3 0.5 1.4 1 1 0 1 1 1 1 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) ADH_N PF08240.12 CCF34968.1 - 0.0001 22.1 0.1 0.0006 19.7 0.1 2.0 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain MFS_1 PF07690.16 CCF34969.1 - 3.4e-37 128.2 64.9 1.3e-36 126.3 60.9 3.2 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 CCF34969.1 - 4.1e-13 48.6 22.7 6.3e-13 48.0 22.7 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) InaF-motif PF15018.6 CCF34969.1 - 0.047 13.6 1.6 0.17 11.8 1.6 2.0 1 0 0 1 1 1 0 TRP-interacting helix p450 PF00067.22 CCF34970.1 - 1e-52 179.5 0.0 1.4e-52 179.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Amino_oxidase PF01593.24 CCF34971.1 - 3.7e-14 52.9 0.3 1.3e-13 51.1 0.3 1.8 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CCF34971.1 - 6.3e-14 52.0 0.1 1.6e-13 50.7 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 CCF34971.1 - 8.8e-08 31.9 0.0 1.4e-06 28.0 0.1 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CCF34971.1 - 1.4e-06 27.7 0.3 2.5e-06 26.8 0.3 1.4 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 CCF34971.1 - 1.3e-05 25.0 0.3 0.00017 21.3 0.2 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.14 CCF34971.1 - 4.3e-05 22.4 0.1 7.2e-05 21.7 0.1 1.3 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_2 PF07992.14 CCF34971.1 - 0.00018 20.9 0.0 0.00045 19.5 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCF34971.1 - 0.0021 18.6 1.2 0.0065 17.0 0.2 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 CCF34971.1 - 0.0081 15.4 0.0 0.013 14.8 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain ApbA PF02558.16 CCF34971.1 - 0.0096 15.6 0.0 0.017 14.8 0.0 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Thi4 PF01946.17 CCF34971.1 - 0.01 15.1 0.0 0.022 14.0 0.0 1.5 1 0 0 1 1 1 0 Thi4 family Pyr_redox_3 PF13738.6 CCF34971.1 - 0.019 14.2 0.0 0.033 13.4 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DUF4945 PF16303.5 CCF34971.1 - 0.069 13.1 0.0 0.19 11.7 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4945) TrkA_N PF02254.18 CCF34971.1 - 0.099 12.9 0.2 0.28 11.4 0.0 1.9 2 0 0 2 2 2 0 TrkA-N domain NAD_binding_9 PF13454.6 CCF34971.1 - 0.17 11.9 0.6 0.31 11.0 0.1 1.7 2 0 0 2 2 2 0 FAD-NAD(P)-binding SET PF00856.28 CCF34973.1 - 6.3e-13 49.5 0.0 1.1e-12 48.7 0.0 1.4 1 1 0 1 1 1 1 SET domain C2 PF00168.30 CCF34974.1 - 1.3e-10 41.5 0.0 2.8e-10 40.4 0.0 1.6 1 0 0 1 1 1 1 C2 domain zf-C2H2_4 PF13894.6 CCF34975.1 - 0.02 15.7 0.5 0.038 14.8 0.5 1.5 1 0 0 1 1 1 0 C2H2-type zinc finger MRP-S31 PF15433.6 CCF34975.1 - 0.1 12.2 0.9 0.11 12.1 0.9 1.1 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 DUF629 PF04780.12 CCF34975.1 - 0.2 10.2 2.0 0.21 10.1 0.9 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF629) RAB3GAP2_N PF14655.6 CCF34975.1 - 0.24 10.6 1.6 0.31 10.3 1.6 1.2 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus DUF1840 PF08895.11 CCF34975.1 - 0.84 10.0 4.2 0.77 10.1 2.1 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF1840) NTPase_I-T PF01931.18 CCF34976.1 - 6.7e-55 185.3 0.0 7.6e-55 185.1 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF84 Evr1_Alr PF04777.13 CCF34977.1 - 4.9e-26 91.1 0.1 7.4e-26 90.5 0.1 1.3 1 0 0 1 1 1 1 Erv1 / Alr family Proteasome PF00227.26 CCF34978.1 - 1.1e-47 161.9 0.3 1.4e-47 161.7 0.3 1.1 1 0 0 1 1 1 1 Proteasome subunit Glyco_hydro_115 PF15979.5 CCF34982.1 - 8.1e-130 433.2 0.4 8.1e-130 433.2 0.4 1.6 2 0 0 2 2 2 1 Glycosyl hydrolase family 115 GH115_C PF17829.1 CCF34982.1 - 4.1e-43 147.2 0.0 8.6e-43 146.1 0.0 1.6 1 0 0 1 1 1 1 Gylcosyl hydrolase family 115 C-terminal domain Glyco_hydro_18 PF00704.28 CCF34983.1 - 1.5e-15 57.7 0.0 2.2e-15 57.2 0.0 1.3 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 Ceramidase PF05875.12 CCF34984.1 - 3.2e-06 26.8 0.5 3.6e-06 26.6 0.5 1.0 1 0 0 1 1 1 1 Ceramidase Prefoldin_2 PF01920.20 CCF34985.1 - 1.6e-18 66.6 3.2 1.9e-18 66.4 3.0 1.2 1 1 0 1 1 1 1 Prefoldin subunit TMF_TATA_bd PF12325.8 CCF34985.1 - 0.0012 19.0 4.8 0.0038 17.4 0.5 2.1 2 0 0 2 2 2 1 TATA element modulatory factor 1 TATA binding Uso1_p115_C PF04871.13 CCF34985.1 - 0.092 13.1 3.5 0.43 11.0 0.3 2.0 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF641 PF04859.12 CCF34985.1 - 0.11 12.8 3.5 0.86 10.0 0.2 2.1 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) CdvA PF18822.1 CCF34985.1 - 0.53 10.1 9.4 6.9 6.5 3.4 3.0 2 1 0 2 2 2 0 CdvA-like coiled-coil domain DUF4200 PF13863.6 CCF34985.1 - 0.63 10.5 9.5 0.82 10.1 0.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) FliJ PF02050.16 CCF34985.1 - 0.74 10.1 11.2 2.3 8.4 3.7 2.1 2 0 0 2 2 2 0 Flagellar FliJ protein OmpH PF03938.14 CCF34985.1 - 0.75 10.1 8.5 0.68 10.3 1.3 2.1 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) TMF_DNA_bd PF12329.8 CCF34985.1 - 0.76 9.8 8.3 0.18 11.8 3.7 2.0 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding IFT20 PF14931.6 CCF34985.1 - 0.93 9.7 7.6 0.36 11.0 1.1 2.1 2 0 0 2 2 2 0 Intraflagellar transport complex B, subunit 20 PKcGMP_CC PF16808.5 CCF34985.1 - 1 9.3 5.5 0.6 10.0 1.8 2.2 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase FlaC_arch PF05377.11 CCF34985.1 - 2.6 8.5 4.8 4.3 7.8 0.4 2.5 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF16 PF01519.16 CCF34985.1 - 2.6 8.6 7.2 1.8 9.1 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function DUF16 Swi5 PF07061.11 CCF34985.1 - 2.8 8.1 8.6 4.1 7.6 2.2 2.2 2 0 0 2 2 2 0 Swi5 PspA_IM30 PF04012.12 CCF34985.1 - 3 7.4 11.1 3.9 7.0 2.3 2.1 2 0 0 2 2 2 0 PspA/IM30 family ABC_tran_CTD PF16326.5 CCF34985.1 - 5 7.5 9.8 4.5 7.6 1.1 2.2 2 0 0 2 2 2 0 ABC transporter C-terminal domain THOC7 PF05615.13 CCF34985.1 - 5.7 7.2 9.6 13 6.0 1.8 2.1 2 0 0 2 2 2 0 Tho complex subunit 7 Nop53 PF07767.11 CCF34986.1 - 4.1 6.7 50.1 7.7 5.8 50.1 1.5 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Mito_carr PF00153.27 CCF34987.1 - 4.9e-32 109.7 0.7 1.2e-17 63.6 0.2 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein HMG-CoA_red PF00368.18 CCF34989.1 - 4.2e-84 282.7 0.0 5e-84 282.4 0.0 1.0 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase TMEM154 PF15102.6 CCF34990.1 - 0.0052 16.7 0.0 0.0074 16.2 0.0 1.2 1 0 0 1 1 1 1 TMEM154 protein family DUF3377 PF11857.8 CCF34990.1 - 0.046 13.6 0.1 0.073 13.0 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) OSTbeta PF15048.6 CCF34990.1 - 0.13 12.4 0.0 0.17 12.0 0.0 1.2 1 0 0 1 1 1 0 Organic solute transporter subunit beta protein EphA2_TM PF14575.6 CCF34990.1 - 0.16 12.9 0.1 0.19 12.6 0.1 1.3 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Peptidase_C65 PF10275.9 CCF34991.1 - 1.3e-52 178.8 0.0 1.4e-52 178.6 0.0 1.0 1 0 0 1 1 1 1 Peptidase C65 Otubain AMP-binding PF00501.28 CCF34993.1 - 8.2e-90 301.4 0.0 5e-70 236.2 0.0 3.8 3 1 1 4 4 4 3 AMP-binding enzyme Condensation PF00668.20 CCF34993.1 - 9.2e-41 140.0 0.0 8.7e-30 103.8 0.0 3.7 2 2 0 2 2 2 2 Condensation domain PP-binding PF00550.25 CCF34993.1 - 3.1e-19 69.1 0.0 4.4e-09 36.6 0.0 2.7 2 0 0 2 2 2 2 Phosphopantetheine attachment site AMP-binding_C PF13193.6 CCF34993.1 - 6e-05 23.9 0.1 0.66 11.0 0.0 3.6 4 0 0 4 4 4 2 AMP-binding enzyme C-terminal domain PvlArgDC PF01862.16 CCF34993.1 - 0.2 11.5 0.1 0.38 10.5 0.1 1.4 1 0 0 1 1 1 0 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) Sugar_tr PF00083.24 CCF34994.1 - 1.8e-120 402.9 23.4 2.1e-120 402.7 23.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF34994.1 - 1.9e-21 76.4 45.7 4.6e-14 52.1 19.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Acetyltransf_10 PF13673.7 CCF34995.1 - 3.1e-10 40.1 0.0 5.2e-10 39.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CCF34995.1 - 5.5e-09 36.3 0.0 8e-09 35.8 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CCF34995.1 - 2.2e-07 31.2 0.0 3.4e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 CCF34995.1 - 2.1e-05 24.6 0.0 3.9e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_9 PF13527.7 CCF34995.1 - 0.0011 19.0 0.0 0.029 14.4 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CCF34995.1 - 0.015 15.2 0.0 0.031 14.2 0.0 1.5 1 1 0 1 1 1 0 FR47-like protein SIP1 PF04938.12 CCF34996.1 - 3.1e-06 27.1 0.0 9.3e-05 22.2 0.0 2.9 2 1 0 2 2 2 1 Survival motor neuron (SMN) interacting protein 1 (SIP1) CPSase_L_D3 PF02787.19 CCF34996.1 - 0.074 13.4 0.1 0.14 12.5 0.1 1.4 1 0 0 1 1 1 0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain DUF2502 PF10697.9 CCF34996.1 - 0.13 12.7 3.2 0.34 11.3 3.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2502) RNR_inhib PF08591.10 CCF34997.1 - 5e-33 114.6 0.1 1.1e-32 113.5 0.1 1.6 1 0 0 1 1 1 1 Ribonucleotide reductase inhibitor Ald_Xan_dh_C2 PF02738.18 CCF34999.1 - 1.7e-92 310.6 0.0 2.1e-92 310.4 0.0 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase DUF218 PF02698.17 CCF34999.1 - 0.0012 18.9 0.0 0.002 18.1 0.0 1.3 1 0 0 1 1 1 1 DUF218 domain Sel1 PF08238.12 CCF35000.1 - 0.055 14.2 0.2 0.4 11.4 0.0 2.4 2 0 0 2 2 2 0 Sel1 repeat PAS PF00989.25 CCF35000.1 - 0.074 13.0 0.0 0.18 11.8 0.0 1.7 2 0 0 2 2 2 0 PAS fold DUF104 PF01954.16 CCF35000.1 - 0.21 12.0 0.1 0.42 11.1 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF104 DUF1213 PF06740.12 CCF35000.1 - 0.63 10.7 0.1 0.63 10.7 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1213) Transp_cyt_pur PF02133.15 CCF35001.1 - 3e-35 121.8 34.7 4.4e-35 121.3 34.7 1.3 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Rick_17kDa_Anti PF05433.15 CCF35001.1 - 3.5 7.6 12.0 0.1 12.5 3.1 2.6 2 0 0 2 2 2 0 Glycine zipper 2TM domain CoA_transf_3 PF02515.17 CCF35003.1 - 9.6e-44 150.0 0.0 2.7e-43 148.5 0.0 1.7 2 0 0 2 2 2 1 CoA-transferase family III FAD_binding_3 PF01494.19 CCF35004.1 - 6e-12 45.5 0.0 2.5e-11 43.4 0.0 2.0 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CCF35004.1 - 0.0023 17.2 0.0 0.0041 16.4 0.0 1.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCF35004.1 - 0.008 15.5 0.1 0.012 14.9 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCF35004.1 - 0.019 15.2 0.0 0.048 13.9 0.0 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 CCF35004.1 - 0.08 11.6 0.1 0.13 11.0 0.1 1.2 1 0 0 1 1 1 0 HI0933-like protein SesA PF17107.5 CCF35005.1 - 3.5e-36 124.1 2.8 4.6e-36 123.7 1.4 1.7 2 0 0 2 2 2 1 N-terminal domain on NACHT_NTPase and P-loop NTPases Helo_like_N PF17111.5 CCF35005.1 - 0.00062 19.2 1.4 0.0011 18.4 0.1 1.7 1 1 1 2 2 2 1 Fungal N-terminal domain of STAND proteins Cdh1_DBD_1 PF18196.1 CCF35005.1 - 0.046 14.0 2.2 0.053 13.8 0.2 1.8 1 1 1 2 2 2 0 Chromodomain helicase DNA-binding domain 1 DUF3549 PF12069.8 CCF35005.1 - 0.06 12.4 1.3 0.073 12.1 1.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3549) DUF2408 PF10303.9 CCF35005.1 - 0.08 13.5 4.5 0.48 11.0 5.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2408) AAA_25 PF13481.6 CCF35005.1 - 0.14 11.8 0.1 0.2 11.2 0.1 1.3 1 0 0 1 1 1 0 AAA domain Ank_2 PF12796.7 CCF35006.1 - 7.2e-51 170.7 0.1 6e-13 49.2 0.0 4.6 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CCF35006.1 - 4.4e-32 106.5 0.1 0.00091 19.5 0.0 8.8 8 0 0 8 8 8 7 Ankyrin repeat Ank_4 PF13637.6 CCF35006.1 - 4.4e-29 100.5 4.7 5e-09 36.5 0.0 7.2 1 1 6 7 7 7 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 CCF35006.1 - 6.1e-29 99.7 4.5 1.3e-06 28.6 0.1 6.3 3 3 3 6 6 6 6 Ankyrin repeats (many copies) Ank PF00023.30 CCF35006.1 - 4.2e-21 74.4 0.7 0.014 15.8 0.0 8.4 8 0 0 8 8 8 4 Ankyrin repeat NACHT PF05729.12 CCF35006.1 - 0.0002 21.3 0.1 0.00044 20.2 0.1 1.6 1 0 0 1 1 1 1 NACHT domain Humanin PF15040.6 CCF35006.1 - 0.087 12.3 0.1 0.22 11.0 0.1 1.7 1 0 0 1 1 1 0 Humanin family HET PF06985.11 CCF35007.1 - 2.7e-27 95.9 0.2 2.4e-25 89.6 0.0 2.4 2 0 0 2 2 2 2 Heterokaryon incompatibility protein (HET) F-box-like PF12937.7 CCF35009.1 - 5.3e-08 32.6 0.4 1.3e-07 31.4 0.4 1.7 1 0 0 1 1 1 1 F-box-like 2-Hacid_dh_C PF02826.19 CCF35010.1 - 1.1e-39 135.6 0.0 1.8e-39 135.0 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CCF35010.1 - 2.4e-10 40.2 0.0 3.3e-10 39.7 0.0 1.3 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain GFO_IDH_MocA PF01408.22 CCF35010.1 - 0.0011 19.8 0.0 0.0019 19.0 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold TrkA_N PF02254.18 CCF35010.1 - 0.0044 17.3 0.0 0.026 14.8 0.0 2.2 2 1 0 2 2 2 1 TrkA-N domain F420_oxidored PF03807.17 CCF35010.1 - 0.0055 17.3 0.1 0.011 16.3 0.1 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Gp_dh_N PF00044.24 CCF35010.1 - 0.01 16.1 0.0 0.023 15.0 0.0 1.6 1 0 0 1 1 1 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 CCF35010.1 - 0.014 15.7 0.1 0.039 14.2 0.1 1.8 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain DapB_N PF01113.20 CCF35010.1 - 0.02 15.0 0.0 0.041 14.0 0.0 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus UDPG_MGDP_dh_C PF03720.15 CCF35010.1 - 0.031 14.7 0.0 9.6 6.7 0.0 2.4 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain NAD_binding_2 PF03446.15 CCF35010.1 - 0.043 14.0 0.1 0.089 13.0 0.1 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase AAA PF00004.29 CCF35012.1 - 1.6e-49 167.7 0.0 2e-43 148.0 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CCF35012.1 - 0.00012 22.5 0.1 0.022 15.2 0.0 2.9 1 1 0 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 CCF35012.1 - 0.00019 21.2 0.0 0.00057 19.7 0.0 1.8 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain Parvo_NS1 PF01057.17 CCF35012.1 - 0.00078 18.6 0.0 0.0013 17.8 0.0 1.2 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 AAA_22 PF13401.6 CCF35012.1 - 0.0009 19.5 0.1 0.039 14.2 0.0 2.8 2 1 1 3 3 3 1 AAA domain AAA_lid_3 PF17862.1 CCF35012.1 - 0.0014 18.4 3.0 0.12 12.2 0.1 2.9 3 0 0 3 3 3 1 AAA+ lid domain AAA_25 PF13481.6 CCF35012.1 - 0.0033 17.0 0.1 0.021 14.4 0.0 2.3 2 1 0 2 2 2 1 AAA domain AAA_2 PF07724.14 CCF35012.1 - 0.004 17.3 0.0 0.0093 16.1 0.0 1.6 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.17 CCF35012.1 - 0.0068 16.2 0.0 0.016 14.9 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein RNA_helicase PF00910.22 CCF35012.1 - 0.012 16.0 0.0 0.039 14.3 0.0 1.9 1 0 0 1 1 1 0 RNA helicase TIP49 PF06068.13 CCF35012.1 - 0.013 14.7 0.0 0.021 14.0 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain Mg_chelatase PF01078.21 CCF35012.1 - 0.022 14.1 0.9 0.057 12.8 0.1 2.0 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 CCF35012.1 - 0.037 14.0 0.0 0.14 12.2 0.0 2.0 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) ATPase PF06745.13 CCF35012.1 - 0.041 13.2 0.0 0.085 12.2 0.0 1.4 1 0 0 1 1 1 0 KaiC AAA_7 PF12775.7 CCF35012.1 - 0.054 13.0 0.0 0.1 12.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_18 PF13238.6 CCF35012.1 - 0.068 13.7 0.0 0.18 12.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 CCF35012.1 - 0.091 12.2 0.0 0.18 11.2 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein AAA_28 PF13521.6 CCF35012.1 - 0.091 13.0 0.0 0.25 11.5 0.0 1.8 2 0 0 2 2 1 0 AAA domain AAA_33 PF13671.6 CCF35012.1 - 0.1 12.7 0.0 0.4 10.8 0.0 2.0 2 0 0 2 2 1 0 AAA domain TsaE PF02367.17 CCF35012.1 - 0.12 12.4 0.0 0.25 11.4 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF815 PF05673.13 CCF35012.1 - 0.17 11.0 0.0 0.32 10.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) FXR_C1 PF16096.5 CCF35012.1 - 7.4 6.9 9.5 0.69 10.2 3.8 2.3 2 0 0 2 2 2 0 Fragile X-related 1 protein C-terminal region 2 OPT PF03169.15 CCF35014.1 - 1.4e-163 545.9 45.0 1.7e-163 545.6 45.0 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein COX7C PF02935.16 CCF35014.1 - 2.1 8.7 10.6 3.3 8.0 1.8 3.3 2 0 0 2 2 2 0 Cytochrome c oxidase subunit VIIc MBF1 PF08523.10 CCF35015.1 - 7.4e-27 93.6 2.2 1.4e-26 92.7 2.2 1.5 1 0 0 1 1 1 1 Multiprotein bridging factor 1 HTH_3 PF01381.22 CCF35015.1 - 9.4e-11 41.6 0.0 1.5e-10 40.9 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 CCF35015.1 - 0.003 17.9 0.0 0.006 16.9 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain MRP-L27 PF09809.9 CCF35015.1 - 0.011 15.6 0.0 0.014 15.2 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L27 CDT1_C PF16679.5 CCF35016.1 - 1.8e-20 73.2 0.4 1.8e-20 73.2 0.4 2.4 3 0 0 3 3 3 1 DNA replication factor Cdt1 C-terminal domain Peptidase_S8 PF00082.22 CCF35018.1 - 2.1e-27 96.2 1.4 1.8e-25 89.8 0.1 2.1 2 0 0 2 2 2 2 Subtilase family RICTOR_V PF14668.6 CCF35019.1 - 0.034 14.4 0.4 0.18 12.1 0.4 2.2 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, domain 5 Transp_cyt_pur PF02133.15 CCF35020.1 - 1.5e-33 116.2 28.1 2.9e-32 112.0 28.1 2.0 1 1 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Glyco_hydro_47 PF01532.20 CCF35021.1 - 1.8e-174 581.0 0.0 2.1e-174 580.8 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Alpha-L-AF_C PF06964.12 CCF35022.1 - 3.3e-32 111.9 0.1 4.1e-32 111.6 0.1 1.0 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase C-terminal domain FlgD_ig PF13860.6 CCF35022.1 - 0.021 14.7 0.7 0.038 13.9 0.7 1.3 1 0 0 1 1 1 0 FlgD Ig-like domain Tup_N PF08581.10 CCF35023.1 - 0.00094 19.4 12.4 0.36 11.2 0.0 6.1 5 0 0 5 5 5 2 Tup N-terminal Ish1 PF10281.9 CCF35023.1 - 0.015 15.6 0.3 53 4.2 0.0 4.9 4 0 0 4 4 4 0 Putative stress-responsive nuclear envelope protein Baculo_PEP_C PF04513.12 CCF35023.1 - 0.036 14.1 41.5 1.7 8.7 0.3 9.1 5 2 5 10 10 10 0 Baculovirus polyhedron envelope protein, PEP, C terminus AvrB_AvrC PF05394.11 CCF35023.1 - 2.5 7.2 8.4 0.73 9.0 2.5 2.7 3 0 0 3 3 3 0 Avirulence protein RTA1 PF04479.13 CCF35025.1 - 4.5e-44 150.5 5.8 6.4e-44 150.0 5.8 1.2 1 0 0 1 1 1 1 RTA1 like protein DUF4501 PF14946.6 CCF35025.1 - 0.071 13.2 0.1 0.071 13.2 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4501) Inp1 PF12634.7 CCF35026.1 - 3.6e-34 117.7 0.1 2.5e-33 115.0 0.0 2.3 2 0 0 2 2 2 1 Inheritance of peroxisomes protein 1 COesterase PF00135.28 CCF35028.1 - 1.9e-65 221.7 0.0 2.9e-65 221.1 0.0 1.2 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CCF35028.1 - 1.3e-08 35.0 0.5 1.2e-07 31.8 0.5 2.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CCF35028.1 - 0.0022 17.5 1.2 0.004 16.7 0.9 1.4 1 1 0 1 1 1 1 Prolyl oligopeptidase family Chlorophyllase2 PF12740.7 CCF35028.1 - 0.044 12.7 0.0 0.081 11.8 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase enzyme Say1_Mug180 PF10340.9 CCF35028.1 - 0.051 12.4 0.0 2.2 7.1 0.0 2.1 2 0 0 2 2 2 0 Steryl acetyl hydrolase DUF3605 PF12239.8 CCF35029.1 - 1.3e-47 162.0 0.1 1.6e-47 161.6 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3605) CP_ATPgrasp_2 PF14403.6 CCF35029.1 - 0.037 13.0 0.0 0.059 12.3 0.0 1.2 1 0 0 1 1 1 0 Circularly permuted ATP-grasp type 2 His_Phos_2 PF00328.22 CCF35030.1 - 1.2e-13 51.3 0.0 5.8e-08 32.5 0.0 2.1 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 2) ABM PF03992.16 CCF35030.1 - 0.031 14.4 0.0 0.094 12.8 0.0 1.8 1 0 0 1 1 1 0 Antibiotic biosynthesis monooxygenase His_Phos_1 PF00300.22 CCF35030.1 - 0.15 11.7 0.0 4.2 7.0 0.0 2.2 2 0 0 2 2 2 0 Histidine phosphatase superfamily (branch 1) Hexapep_2 PF14602.6 CCF35031.1 - 1.8e-13 50.0 7.7 2e-10 40.2 2.2 3.1 3 0 0 3 3 3 2 Hexapeptide repeat of succinyl-transferase Hexapep PF00132.24 CCF35031.1 - 2.2e-13 49.4 6.9 5e-09 35.5 2.6 3.3 3 0 0 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Mac PF12464.8 CCF35031.1 - 6.2e-10 39.2 0.2 9.8e-10 38.5 0.2 1.3 1 0 0 1 1 1 1 Maltose acetyltransferase YTV PF07639.11 CCF35032.1 - 0.027 14.5 0.3 0.04 14.0 0.3 1.3 1 0 0 1 1 1 0 YTV Rtt106 PF08512.12 CCF35032.1 - 0.12 12.8 0.8 0.14 12.6 0.8 1.1 1 0 0 1 1 1 0 Histone chaperone Rttp106-like adh_short PF00106.25 CCF35034.1 - 3.3e-18 65.8 0.0 1.7e-15 57.0 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCF35034.1 - 2e-08 34.1 0.0 4.5e-08 32.9 0.0 1.5 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF35034.1 - 0.0001 22.3 0.1 0.00015 21.7 0.1 1.2 1 0 0 1 1 1 1 KR domain Pkinase PF00069.25 CCF35035.1 - 8.3e-16 58.1 0.0 1.3e-14 54.2 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF35035.1 - 1.2e-08 34.6 0.0 2e-07 30.6 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 CCF35035.1 - 0.00026 20.4 0.0 0.0004 19.8 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 CCF35035.1 - 0.16 11.5 0.0 0.25 10.9 0.0 1.2 1 0 0 1 1 1 0 RIO1 family MFS_1 PF07690.16 CCF35036.1 - 7.1e-44 150.2 26.1 7.1e-44 150.2 26.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF35036.1 - 7.6e-13 48.1 8.8 7.6e-13 48.1 8.8 2.5 3 0 0 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.13 CCF35036.1 - 2.8e-11 42.6 3.1 4.9e-11 41.8 3.1 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_1_like PF12832.7 CCF35036.1 - 0.077 11.8 11.2 0.11 11.3 0.1 2.8 2 1 1 4 4 4 0 MFS_1 like family MFS_3 PF05977.13 CCF35036.1 - 0.21 9.9 9.4 0.011 14.1 3.5 1.8 2 0 0 2 2 2 0 Transmembrane secretion effector MFS_1 PF07690.16 CCF35037.1 - 2.6e-32 112.1 14.3 2.6e-32 112.1 14.3 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily U3_assoc_6 PF08640.11 CCF35037.1 - 0.082 13.0 0.0 0.15 12.2 0.0 1.3 1 0 0 1 1 1 0 U3 small nucleolar RNA-associated protein 6 Caleosin PF05042.13 CCF35038.1 - 2.3e-69 232.7 0.0 2.7e-69 232.4 0.0 1.1 1 0 0 1 1 1 1 Caleosin related protein EF-hand_6 PF13405.6 CCF35038.1 - 3.3e-05 23.4 0.3 2.4 8.3 0.0 3.6 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 CCF35038.1 - 0.037 13.6 0.2 5 6.9 0.0 3.5 3 0 0 3 3 3 0 EF hand CitT PF12431.8 CCF35039.1 - 1 9.8 2.8 2 8.8 0.1 3.2 2 0 0 2 2 2 0 Transcriptional regulator Xpo1 PF08389.12 CCF35040.1 - 1.8e-29 102.7 1.8 1.5e-28 99.7 0.2 3.5 3 2 2 5 5 5 1 Exportin 1-like protein IBN_N PF03810.19 CCF35040.1 - 7.7e-07 28.9 0.0 4.2e-06 26.6 0.0 2.4 2 0 0 2 2 2 1 Importin-beta N-terminal domain Importin_rep_3 PF18806.1 CCF35040.1 - 0.00063 19.7 0.0 0.13 12.3 0.0 3.9 3 1 0 3 3 3 1 Importin 13 repeat Adaptin_N PF01602.20 CCF35040.1 - 0.0045 15.6 0.7 0.23 10.0 0.1 2.5 2 0 0 2 2 2 2 Adaptin N terminal region UME PF08064.13 CCF35040.1 - 0.012 15.5 2.9 3.5 7.6 0.0 5.5 6 0 0 6 6 6 0 UME (NUC010) domain HEAT_EZ PF13513.6 CCF35040.1 - 0.014 15.9 0.1 1.7 9.2 0.0 4.3 4 0 0 4 4 4 0 HEAT-like repeat Pox_F16 PF04708.12 CCF35040.1 - 0.085 12.3 0.0 0.18 11.2 0.0 1.5 1 0 0 1 1 1 0 Poxvirus F16 protein COG4 PF08318.12 CCF35041.1 - 1.1e-127 425.7 0.0 1.7e-127 425.2 0.0 1.3 1 0 0 1 1 1 1 COG4 transport protein TetR_C_12 PF16914.5 CCF35041.1 - 0.001 19.1 0.5 0.026 14.6 0.1 3.0 2 1 1 3 3 3 1 Bacterial transcriptional repressor C-terminal HSCB_C PF07743.13 CCF35041.1 - 0.019 15.5 4.3 0.16 12.5 0.4 3.4 3 0 0 3 3 3 0 HSCB C-terminal oligomerisation domain Autophagy_C PF10381.9 CCF35041.1 - 1.8 8.2 5.4 11 5.6 0.9 2.4 2 0 0 2 2 2 0 Autophagocytosis associated protein C-terminal E1-E2_ATPase PF00122.20 CCF35042.1 - 1.3e-43 148.7 0.1 1.3e-43 148.7 0.1 1.8 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 CCF35042.1 - 1.4e-42 145.4 0.8 2.7e-42 144.5 0.8 1.5 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 CCF35042.1 - 3.6e-22 79.7 0.0 2.9e-21 76.7 0.0 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 CCF35042.1 - 4.1e-20 71.2 0.0 8e-20 70.3 0.0 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 CCF35042.1 - 8.1e-12 45.1 0.0 1.6e-11 44.1 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 CCF35042.1 - 0.00052 19.8 0.3 0.001 18.9 0.3 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 CCF35042.1 - 0.011 16.1 0.0 0.042 14.3 0.0 2.0 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase C2 PF00168.30 CCF35043.1 - 3.4e-16 59.4 0.0 7.1e-16 58.4 0.0 1.6 1 0 0 1 1 1 1 C2 domain PAT1 PF09770.9 CCF35043.1 - 9.3 4.4 21.5 28 2.8 21.5 1.8 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Peptidase_M24 PF00557.24 CCF35044.1 - 3.6e-39 134.6 0.1 4.6e-39 134.3 0.1 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 YL1 PF05764.13 CCF35044.1 - 0.013 15.7 3.3 0.017 15.3 3.3 1.2 1 0 0 1 1 1 0 YL1 nuclear protein TSGP1 PF07771.11 CCF35044.1 - 0.65 10.2 8.8 1.5 9.0 8.8 1.5 1 0 0 1 1 1 0 Tick salivary peptide group 1 MIP PF00230.20 CCF35045.1 - 1.8e-53 181.6 6.7 2.2e-53 181.3 6.7 1.1 1 0 0 1 1 1 1 Major intrinsic protein CathepsinC_exc PF08773.11 CCF35049.1 - 0.035 14.4 0.2 0.043 14.1 0.2 1.1 1 0 0 1 1 1 0 Cathepsin C exclusion domain AHD PF17793.1 CCF35049.1 - 0.13 12.1 0.1 5.5 6.9 0.0 2.2 1 1 1 2 2 2 0 ANC1 homology domain (AHD) DUF1749 PF08538.10 CCF35050.1 - 2.6e-77 259.9 0.0 3.1e-77 259.6 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1749) Hydrolase_4 PF12146.8 CCF35050.1 - 5.7e-06 25.8 0.0 0.00052 19.4 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CCF35050.1 - 1.4e-05 25.8 0.0 1.7e-05 25.5 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CCF35050.1 - 4.6e-05 23.2 0.0 0.0014 18.4 0.0 2.1 2 0 0 2 2 2 1 alpha/beta hydrolase fold MFS_1 PF07690.16 CCF35052.1 - 1.6e-25 89.8 23.1 1.9e-25 89.5 23.1 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Cyd_oper_YbgE PF09600.10 CCF35052.1 - 5.3 7.5 11.7 0.16 12.3 3.2 2.9 2 0 0 2 2 2 0 Cyd operon protein YbgE (Cyd_oper_YbgE) DEAD PF00270.29 CCF35054.1 - 5.4e-22 78.4 0.1 1.6e-21 76.8 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF35054.1 - 4e-21 75.4 0.2 1.9e-16 60.4 0.0 3.1 3 0 0 3 3 3 2 Helicase conserved C-terminal domain RecQ_Zn_bind PF16124.5 CCF35054.1 - 2.2e-16 60.3 5.2 6.9e-16 58.7 5.2 2.0 1 0 0 1 1 1 1 RecQ zinc-binding RQC PF09382.10 CCF35054.1 - 2.6e-13 49.7 0.1 8.6e-13 48.1 0.0 2.0 2 0 0 2 2 2 1 RQC domain ResIII PF04851.15 CCF35054.1 - 7e-08 32.7 0.0 2e-07 31.2 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HRDC PF00570.23 CCF35054.1 - 0.00052 19.9 0.0 0.0015 18.4 0.0 1.8 1 0 0 1 1 1 1 HRDC domain SecA_DEAD PF07517.14 CCF35054.1 - 0.028 13.7 0.0 0.066 12.5 0.0 1.6 1 0 0 1 1 1 0 SecA DEAD-like domain IFT57 PF10498.9 CCF35054.1 - 2.2 7.2 11.1 0.024 13.6 2.4 2.2 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 KAR9 PF08580.10 CCF35055.1 - 1.1e-169 566.2 0.0 1.1e-169 566.2 0.0 2.5 2 1 0 3 3 3 1 Yeast cortical protein KAR9 Syntaxin-6_N PF09177.11 CCF35055.1 - 0.013 16.1 7.5 0.69 10.5 0.4 4.4 3 1 1 4 4 4 0 Syntaxin 6, N-terminal PLU-1 PF08429.11 CCF35055.1 - 0.063 12.4 2.6 2.1 7.4 0.0 3.0 3 0 0 3 3 3 0 PLU-1-like protein Phosphoprotein PF00922.17 CCF35055.1 - 0.064 12.8 0.0 8.6 5.9 0.0 2.4 2 0 0 2 2 2 0 Vesiculovirus phosphoprotein DUF4263 PF14082.6 CCF35055.1 - 0.08 13.2 0.1 12 6.2 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4263) Com_YlbF PF06133.11 CCF35055.1 - 0.17 12.5 0.9 18 6.0 0.1 3.3 3 1 0 3 3 3 0 Control of competence regulator ComK, YlbF/YmcA HET PF06985.11 CCF35056.1 - 6e-26 91.5 0.4 4.1e-25 88.8 0.4 2.3 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Peptidase_S8 PF00082.22 CCF35057.1 - 3.5e-29 102.0 0.0 6.9e-29 101.0 0.0 1.4 1 1 0 1 1 1 1 Subtilase family fn3_5 PF06280.12 CCF35057.1 - 4.6e-08 33.7 0.0 4.5e-07 30.6 0.0 2.3 2 0 0 2 2 2 1 Fn3-like domain PA PF02225.22 CCF35057.1 - 0.014 15.4 0.0 0.04 13.9 0.0 1.8 1 0 0 1 1 1 0 PA domain FlgD_ig PF13860.6 CCF35057.1 - 0.086 12.7 0.0 1.1 9.2 0.1 2.7 2 0 0 2 2 2 0 FlgD Ig-like domain PNTB PF02233.16 CCF35059.1 - 3.3e-173 576.8 29.1 3.3e-173 576.8 29.1 2.1 2 0 0 2 2 2 1 NAD(P) transhydrogenase beta subunit AlaDh_PNT_C PF01262.21 CCF35059.1 - 2.4e-73 246.0 0.0 7.6e-73 244.3 0.0 1.9 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain AlaDh_PNT_N PF05222.15 CCF35059.1 - 3.9e-49 166.5 0.0 9.3e-49 165.2 0.0 1.7 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain PNTB_4TM PF12769.7 CCF35059.1 - 1.6e-30 105.4 3.0 1.6e-30 105.4 3.0 5.0 3 1 1 4 4 4 1 4TM region of pyridine nucleotide transhydrogenase, mitoch 2-Hacid_dh_C PF02826.19 CCF35059.1 - 0.012 15.0 0.1 0.62 9.4 0.0 2.6 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.14 CCF35059.1 - 0.012 14.9 1.2 0.032 13.5 0.1 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase ADH_zinc_N PF00107.26 CCF35059.1 - 0.022 14.8 0.1 0.12 12.4 0.1 2.3 1 1 0 1 1 1 0 Zinc-binding dehydrogenase NAD_binding_8 PF13450.6 CCF35059.1 - 0.062 13.5 1.6 0.47 10.7 1.7 2.7 2 1 0 2 2 2 0 NAD(P)-binding Rossmann-like domain TPP_enzyme_M PF00205.22 CCF35059.1 - 0.11 12.2 0.5 0.77 9.5 0.5 2.5 1 1 0 1 1 1 0 Thiamine pyrophosphate enzyme, central domain Fumerase PF05681.14 CCF35059.1 - 0.11 11.8 0.1 0.2 11.0 0.1 1.3 1 0 0 1 1 1 0 Fumarate hydratase (Fumerase) NAD_binding_7 PF13241.6 CCF35060.1 - 1.6e-31 108.8 0.0 2.6e-31 108.2 0.0 1.3 1 0 0 1 1 1 1 Putative NAD(P)-binding Sirohm_synth_C PF14823.6 CCF35060.1 - 2.9e-26 90.9 0.0 4.5e-26 90.3 0.0 1.3 1 0 0 1 1 1 1 Sirohaem biosynthesis protein C-terminal Sirohm_synth_M PF14824.6 CCF35060.1 - 3.6e-16 58.3 0.5 6.4e-16 57.5 0.5 1.4 1 0 0 1 1 1 1 Sirohaem biosynthesis protein central Pyr_redox_3 PF13738.6 CCF35060.1 - 0.00077 18.8 0.0 0.0011 18.3 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase ThiF PF00899.21 CCF35060.1 - 0.046 13.1 0.5 0.42 9.9 0.0 2.1 2 0 0 2 2 2 0 ThiF family TrkA_N PF02254.18 CCF35060.1 - 0.071 13.4 0.1 0.14 12.4 0.1 1.5 1 0 0 1 1 1 0 TrkA-N domain Shikimate_DH PF01488.20 CCF35060.1 - 0.11 12.6 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase FYVE PF01363.21 CCF35061.1 - 2.1e-24 85.5 20.1 4.3e-17 62.0 3.5 2.9 3 0 0 3 3 3 2 FYVE zinc finger Rbsn PF11464.8 CCF35061.1 - 1.1e-17 63.5 4.0 2.3e-17 62.5 4.0 1.6 1 0 0 1 1 1 1 Rabenosyn Rab binding domain zf-Di19 PF05605.12 CCF35061.1 - 0.00029 21.0 6.2 0.017 15.4 0.1 2.9 2 0 0 2 2 2 2 Drought induced 19 protein (Di19), zinc-binding zf-AN1 PF01428.16 CCF35061.1 - 0.00086 19.4 1.8 0.00086 19.4 1.8 3.8 3 1 1 4 4 4 1 AN1-like Zinc finger zf-C2H2_2 PF12756.7 CCF35061.1 - 0.017 15.5 0.3 1.2 9.5 0.0 2.8 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-NADH-PPase PF09297.11 CCF35061.1 - 0.14 11.8 0.2 0.14 11.8 0.2 4.0 5 0 0 5 5 5 0 NADH pyrophosphatase zinc ribbon domain Siva PF05458.12 CCF35061.1 - 0.15 11.8 7.9 0.61 9.7 0.4 2.8 2 1 0 2 2 2 0 Cd27 binding protein (Siva) HypA PF01155.19 CCF35061.1 - 0.26 11.3 8.9 1.2 9.2 0.7 3.5 2 1 1 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C2H2_9 PF16293.5 CCF35061.1 - 0.3 11.0 2.2 9.8 6.1 0.0 2.8 2 0 0 2 2 2 0 C2H2 type zinc-finger (1 copy) UBZ_FAAP20 PF15750.5 CCF35061.1 - 0.67 9.9 2.4 4.9 7.2 0.5 2.8 2 0 0 2 2 2 0 Ubiquitin-binding zinc-finger IBR PF01485.21 CCF35061.1 - 1.7 8.9 13.6 0.49 10.7 1.3 3.3 3 0 0 3 3 3 0 IBR domain, a half RING-finger domain C6_DPF PF10170.9 CCF35061.1 - 4.4 7.7 6.4 0.59 10.5 0.3 2.5 2 1 0 2 2 2 0 Cysteine-rich domain PPR_2 PF13041.6 CCF35064.1 - 1.1e-16 60.7 1.1 0.00021 21.4 0.0 5.4 4 1 1 5 5 5 4 PPR repeat family PPR_3 PF13812.6 CCF35064.1 - 1.7e-06 28.0 0.0 0.059 13.4 0.0 3.8 4 0 0 4 4 4 2 Pentatricopeptide repeat domain PPR PF01535.20 CCF35064.1 - 1.9e-05 24.6 13.1 0.00064 19.8 0.0 5.3 6 1 0 6 6 6 2 PPR repeat PPR_1 PF12854.7 CCF35064.1 - 0.00049 19.7 4.4 1.9 8.2 0.0 4.3 4 1 0 4 4 4 2 PPR repeat DUF2095 PF09868.9 CCF35064.1 - 0.055 13.4 0.0 0.14 12.2 0.0 1.7 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2095) PPR_long PF17177.4 CCF35064.1 - 0.11 11.8 0.0 0.54 9.6 0.0 2.0 2 1 0 2 2 2 0 Pentacotripeptide-repeat region of PRORP COX7C PF02935.16 CCF35065.1 - 2.4e-24 85.4 3.8 4.3e-24 84.5 3.8 1.4 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIIc Amidase PF01425.21 CCF35065.1 - 0.12 11.3 0.0 0.13 11.2 0.0 1.0 1 0 0 1 1 1 0 Amidase rRNA_proc-arch PF13234.6 CCF35066.1 - 1.8e-84 283.9 0.0 4.4e-84 282.6 0.0 1.7 1 0 0 1 1 1 1 rRNA-processing arch domain DSHCT PF08148.12 CCF35066.1 - 4.6e-49 166.2 3.0 7.9e-49 165.5 1.5 2.1 2 0 0 2 2 2 1 DSHCT (NUC185) domain DEAD PF00270.29 CCF35066.1 - 3.7e-19 69.1 0.0 3e-18 66.2 0.0 2.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF35066.1 - 2.8e-08 34.1 0.1 1.7e-07 31.6 0.1 2.3 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCF35066.1 - 2.1e-05 24.6 0.0 7e-05 22.9 0.0 1.9 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit T2SSE PF00437.20 CCF35066.1 - 0.022 13.8 0.0 0.054 12.5 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_22 PF13401.6 CCF35066.1 - 0.039 14.2 0.0 0.22 11.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain DUF2407_C PF13373.6 CCF35067.1 - 8.5e-13 48.7 0.5 9.2e-13 48.6 0.5 1.0 1 0 0 1 1 1 1 DUF2407 C-terminal domain CAP_N PF01213.19 CCF35068.1 - 0.59 9.6 8.6 0.57 9.6 8.6 1.0 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Glyco_hydro_76 PF03663.14 CCF35069.1 - 6.4e-162 539.2 13.9 7.5e-162 539.0 13.9 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 CCF35069.1 - 0.0091 15.1 11.8 0.15 11.1 0.4 3.4 3 1 1 4 4 4 3 Glycosyl Hydrolase Family 88 2OG-FeII_Oxy_3 PF13640.6 CCF35070.1 - 2.8e-09 37.7 0.2 5.3e-09 36.9 0.0 1.5 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily PNP_phzG_C PF10590.9 CCF35070.1 - 0.89 9.7 3.8 1.4 9.0 0.5 2.3 2 0 0 2 2 2 0 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region DUF3176 PF11374.8 CCF35071.1 - 5.3e-08 33.0 0.0 5.9e-08 32.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3176) CBM_20 PF00686.19 CCF35072.1 - 2.8e-32 110.5 0.4 4.9e-32 109.7 0.4 1.4 1 0 0 1 1 1 1 Starch binding domain LPMO_10 PF03067.15 CCF35072.1 - 3e-09 37.8 3.4 3.4e-09 37.6 2.3 1.7 2 0 0 2 2 2 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading Pectate_lyase_3 PF12708.7 CCF35073.1 - 3.6e-86 288.5 9.5 3.2e-75 252.7 7.4 2.6 2 0 0 2 2 2 2 Pectate lyase superfamily protein End_N_terminal PF12218.8 CCF35073.1 - 9.5e-07 28.4 1.0 0.011 15.4 0.2 2.7 2 0 0 2 2 2 2 N terminal extension of bacteriophage endosialidase SpdB PF05122.13 CCF35073.1 - 0.087 13.0 3.1 0.23 11.6 3.1 1.7 1 0 0 1 1 1 0 Mobile element transfer protein GFA PF04828.14 CCF35077.1 - 7.2e-25 87.2 0.0 1e-24 86.7 0.0 1.2 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme DZR PF12773.7 CCF35077.1 - 0.094 12.8 3.2 0.8 9.8 0.2 2.5 2 1 0 2 2 2 0 Double zinc ribbon Rif1_N PF12231.8 CCF35079.1 - 2.5e-142 474.3 1.0 3.6e-142 473.8 1.0 1.2 1 0 0 1 1 1 1 Rap1-interacting factor 1 N terminal Vps35 PF03635.17 CCF35079.1 - 0.0042 15.7 0.0 0.05 12.1 0.1 2.0 2 0 0 2 2 2 1 Vacuolar protein sorting-associated protein 35 Gcn1_N PF12074.8 CCF35079.1 - 0.063 12.6 0.0 0.15 11.3 0.0 1.6 1 0 0 1 1 1 0 Generalcontrol nonderepressible 1 (Gcn1) N-terminal Ribosomal_L22e PF01776.17 CCF35080.1 - 5.7e-24 84.6 0.1 7.5e-24 84.2 0.1 1.1 1 0 0 1 1 1 1 Ribosomal L22e protein family DUF3568 PF12092.8 CCF35080.1 - 0.054 13.6 0.6 0.068 13.2 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3568) A_deaminase PF00962.22 CCF35081.1 - 7.8e-24 84.6 0.0 1.5e-23 83.7 0.0 1.4 1 0 0 1 1 1 1 Adenosine/AMP deaminase Formyl_trans_C PF02911.18 CCF35081.1 - 0.11 12.8 0.0 0.22 11.8 0.0 1.5 1 0 0 1 1 1 0 Formyl transferase, C-terminal domain MFS_1 PF07690.16 CCF35082.1 - 4.6e-28 98.2 33.2 1.7e-26 93.0 19.7 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily BSP PF04450.12 CCF35082.1 - 0.12 12.2 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 Peptidase of plants and bacteria Hydantoinase_B PF02538.14 CCF35084.1 - 1.1e-221 736.8 0.1 1.4e-221 736.4 0.1 1.1 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.18 CCF35084.1 - 1.7e-78 263.9 0.3 2.6e-78 263.2 0.3 1.3 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase Polysacc_deac_1 PF01522.21 CCF35086.1 - 8.3e-15 54.8 0.0 3.3e-14 52.9 0.0 1.9 2 0 0 2 2 2 1 Polysaccharide deacetylase Polysacc_deac_2 PF04748.13 CCF35086.1 - 0.14 11.3 0.0 0.26 10.4 0.0 1.4 1 0 0 1 1 1 0 Divergent polysaccharide deacetylase p450 PF00067.22 CCF35087.1 - 1.3e-42 146.1 0.0 3.7e-42 144.7 0.0 1.6 1 1 0 1 1 1 1 Cytochrome P450 Fungal_TACC PF12709.7 CCF35088.1 - 0.018 15.5 0.9 0.018 15.5 0.9 5.0 4 1 1 5 5 5 0 Fungal Transforming acidic coiled-coil (TACC) proteins Filament PF00038.21 CCF35088.1 - 1.1 8.8 49.6 1.3 8.6 1.5 3.4 2 1 1 3 3 3 0 Intermediate filament protein CREPT PF16566.5 CCF35088.1 - 2 8.6 35.8 0.037 14.2 4.0 4.4 4 0 0 4 4 4 0 Cell-cycle alteration and expression-elevated protein in tumour ApoO PF09769.9 CCF35088.1 - 3.7 7.5 23.7 2.6 8.0 0.4 4.5 4 1 0 4 4 4 0 Apolipoprotein O Peptidase_S41 PF03572.18 CCF35089.1 - 7.6e-07 28.8 0.0 2.1e-06 27.4 0.0 1.7 1 1 0 1 1 1 1 Peptidase family S41 BRO1 PF03097.18 CCF35092.1 - 1.1e-132 442.6 0.4 1.1e-132 442.6 0.4 2.3 3 0 0 3 3 3 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 CCF35092.1 - 1.1e-79 267.8 19.0 2.5e-79 266.7 19.0 1.6 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV Phage_tail_APC PF16778.5 CCF35092.1 - 0.16 11.8 2.3 0.3 11.0 0.4 2.5 2 0 0 2 2 2 0 Phage tail assembly chaperone protein Gp58 PF07902.11 CCF35092.1 - 0.3 9.3 7.4 0.76 8.0 7.4 1.6 1 0 0 1 1 1 0 gp58-like protein COG2 PF06148.11 CCF35092.1 - 1 9.4 10.3 0.15 12.1 1.5 3.5 3 0 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF1539 PF07560.11 CCF35092.1 - 3.8 7.6 10.6 1.5 8.9 0.1 3.7 3 1 0 3 3 3 0 Domain of Unknown Function (DUF1539) Cu-oxidase PF00394.22 CCF35095.1 - 1.2e-15 58.0 0.1 2.3e-15 57.1 0.1 1.4 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 CCF35095.1 - 9e-10 38.4 0.1 2.1e-08 34.0 0.0 2.3 2 0 0 2 2 2 1 Multicopper oxidase Abhydrolase_1 PF00561.20 CCF35096.1 - 1.6e-15 57.5 0.0 3.2e-14 53.2 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCF35096.1 - 8.1e-09 36.4 0.2 9.4e-09 36.2 0.2 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCF35096.1 - 1.2e-05 24.7 0.0 0.12 11.6 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_4 PF08386.10 CCF35096.1 - 0.0004 20.4 0.0 0.00065 19.8 0.0 1.3 1 0 0 1 1 1 1 TAP-like protein FSH1 PF03959.13 CCF35096.1 - 0.0029 17.3 0.0 0.011 15.3 0.0 2.0 2 1 1 3 3 3 1 Serine hydrolase (FSH1) Ndr PF03096.14 CCF35096.1 - 0.039 12.6 0.0 0.062 12.0 0.0 1.2 1 0 0 1 1 1 0 Ndr family LIP PF03583.14 CCF35096.1 - 0.056 12.8 0.0 1.2 8.3 0.0 2.2 2 0 0 2 2 2 0 Secretory lipase Abhydrolase_8 PF06259.12 CCF35096.1 - 0.1 12.2 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase Cu-oxidase_3 PF07732.15 CCF35097.1 - 9.9e-32 109.5 0.5 2.4e-30 105.0 0.4 2.8 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 CCF35097.1 - 2e-19 69.7 11.7 9e-16 57.9 1.1 4.2 3 1 0 3 3 3 3 Multicopper oxidase Cu-oxidase PF00394.22 CCF35097.1 - 5.5e-19 68.8 0.0 3.1e-18 66.4 0.0 2.3 3 0 0 3 3 3 1 Multicopper oxidase NmrA PF05368.13 CCF35098.1 - 9.2e-57 192.3 0.4 1.1e-56 192.0 0.4 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CCF35098.1 - 1.9e-16 60.5 0.5 1.9e-16 60.5 0.5 1.3 2 0 0 2 2 2 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 CCF35098.1 - 0.0041 17.4 0.0 0.11 12.7 0.1 2.2 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain Semialdhyde_dh PF01118.24 CCF35098.1 - 0.0064 16.9 0.3 0.012 16.0 0.3 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Pectate_lyase PF03211.13 CCF35099.1 - 4.2e-80 268.1 0.4 5.1e-80 267.8 0.4 1.1 1 0 0 1 1 1 1 Pectate lyase Say1_Mug180 PF10340.9 CCF35101.1 - 3.7e-17 62.2 0.0 1.1e-08 34.4 0.0 2.2 2 0 0 2 2 2 2 Steryl acetyl hydrolase Abhydrolase_3 PF07859.13 CCF35101.1 - 2.4e-14 53.7 0.0 3.9e-14 53.0 0.0 1.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 CCF35101.1 - 0.13 11.1 0.0 0.18 10.6 0.0 1.1 1 0 0 1 1 1 0 Carboxylesterase family mRNA_cap_enzyme PF01331.19 CCF35102.1 - 8.5e-59 198.7 0.9 1.2e-58 198.2 0.9 1.2 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.15 CCF35102.1 - 3.8e-31 107.9 0.0 7.1e-31 107.1 0.0 1.5 1 0 0 1 1 1 1 mRNA capping enzyme, C-terminal domain DNA_ligase_A_M PF01068.21 CCF35102.1 - 6.7e-11 42.2 0.1 6e-07 29.3 0.0 2.3 1 1 1 2 2 2 2 ATP dependent DNA ligase domain RNA_ligase PF09414.10 CCF35102.1 - 0.00016 22.1 0.1 0.00023 21.5 0.1 1.2 1 0 0 1 1 1 1 RNA ligase Aldo_ket_red PF00248.21 CCF35103.1 - 3.8e-41 141.2 0.0 3.4e-39 134.8 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family IBR PF01485.21 CCF35104.1 - 8.6e-10 38.7 39.4 8.3e-06 25.9 3.3 3.8 4 0 0 4 4 4 3 IBR domain, a half RING-finger domain zf-C3HC4_2 PF13923.6 CCF35104.1 - 0.00032 20.5 3.8 0.00032 20.5 3.8 4.1 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CCF35104.1 - 0.00037 20.3 3.4 0.00037 20.3 3.4 3.4 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CCF35104.1 - 0.0016 18.7 4.7 0.0016 18.7 4.7 3.6 3 0 0 3 3 3 1 Ring finger domain zf-RING_UBOX PF13445.6 CCF35104.1 - 0.0019 18.2 4.2 0.0019 18.2 4.2 2.9 3 0 0 3 3 3 1 RING-type zinc-finger zf-RING_5 PF14634.6 CCF35104.1 - 0.0024 17.8 4.0 0.0024 17.8 4.0 3.7 3 0 0 3 3 3 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 CCF35104.1 - 0.0036 17.4 3.0 0.0036 17.4 3.0 3.9 3 2 1 4 4 4 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 CCF35104.1 - 0.004 17.0 4.1 0.004 17.0 4.1 4.3 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 CCF35104.1 - 0.22 11.3 6.4 1.5 8.7 0.1 3.0 2 0 0 2 2 2 0 RING-like zinc finger bZIP_2 PF07716.15 CCF35105.1 - 1.7e-06 28.0 11.9 3.3e-06 27.1 11.9 1.5 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 CCF35105.1 - 1.2e-05 25.3 7.7 2.1e-05 24.5 7.7 1.3 1 0 0 1 1 1 1 bZIP transcription factor DUF641 PF04859.12 CCF35105.1 - 0.0071 16.7 1.6 0.0099 16.2 1.6 1.2 1 0 0 1 1 1 1 Plant protein of unknown function (DUF641) TPD52 PF04201.15 CCF35105.1 - 0.009 15.6 0.5 0.013 15.1 0.5 1.3 1 0 0 1 1 1 1 Tumour protein D52 family SlyX PF04102.12 CCF35105.1 - 0.21 12.2 2.7 0.4 11.3 2.7 1.4 1 0 0 1 1 1 0 SlyX bZIP_Maf PF03131.17 CCF35105.1 - 1.4 9.5 11.6 0.1 13.2 6.7 1.6 2 0 0 2 2 2 0 bZIP Maf transcription factor PKcGMP_CC PF16808.5 CCF35105.1 - 2.7 7.9 7.2 12 5.8 1.2 2.2 1 1 1 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Myb_DNA-binding PF00249.31 CCF35106.1 - 1.1e-14 54.3 2.2 4.1e-11 42.9 0.0 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CCF35106.1 - 3.7e-06 27.1 2.4 0.0042 17.3 0.1 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Ubiquitin_2 PF14560.6 CCF35108.1 - 2.1e-22 79.4 0.0 4.1e-22 78.5 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-like domain CAP_GLY PF01302.25 CCF35108.1 - 3.8e-22 78.1 1.0 5.7e-22 77.5 1.0 1.3 1 0 0 1 1 1 1 CAP-Gly domain ubiquitin PF00240.23 CCF35108.1 - 0.0011 18.7 0.0 0.0027 17.4 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin family T6_Ig_like PF18002.1 CCF35108.1 - 0.049 13.5 0.0 0.075 12.9 0.0 1.2 1 0 0 1 1 1 0 T6 antigen Ig like domain Acetyltransf_1 PF00583.25 CCF35109.1 - 0.037 14.2 0.0 0.26 11.6 0.0 2.2 2 0 0 2 2 2 0 Acetyltransferase (GNAT) family CENP-I PF07778.11 CCF35110.1 - 1.1e-06 27.7 0.0 1.4e-06 27.4 0.0 1.0 1 0 0 1 1 1 1 Mis6 RAMP4 PF06624.12 CCF35113.1 - 3.7e-23 81.4 0.1 4.1e-23 81.2 0.1 1.0 1 0 0 1 1 1 1 Ribosome associated membrane protein RAMP4 Mid1 PF12929.7 CCF35115.1 - 1.6e-158 528.4 3.5 1.9e-158 528.2 3.5 1.0 1 0 0 1 1 1 1 Stretch-activated Ca2+-permeable channel component Fz PF01392.22 CCF35115.1 - 0.0098 16.5 9.5 0.031 14.9 3.1 2.7 3 0 0 3 3 3 2 Fz domain Ras PF00071.22 CCF35117.1 - 1.8e-41 141.4 0.0 2.4e-41 141.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCF35117.1 - 4.3e-22 78.6 0.0 1.2e-21 77.2 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCF35117.1 - 4.7e-06 26.2 0.0 6.6e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Nas2_N PF18265.1 CCF35118.1 - 2.5e-12 46.5 1.8 1.4e-11 44.2 1.8 1.9 1 1 0 1 1 1 1 Nas2 N_terminal domain PDZ_6 PF17820.1 CCF35118.1 - 1.6e-07 31.0 0.0 2.8e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 CCF35118.1 - 9.6e-07 29.1 0.0 1.6e-06 28.3 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 CCF35118.1 - 1.9e-05 24.9 0.0 4.1e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 PDZ domain GRASP55_65 PF04495.14 CCF35118.1 - 0.046 14.0 0.7 6.2 7.1 0.0 2.3 1 1 1 2 2 2 0 GRASP55/65 PDZ-like domain DUF3336 PF11815.8 CCF35118.1 - 0.049 13.4 0.0 0.064 13.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3336) PWI PF01480.17 CCF35119.1 - 5.2e-32 110.0 0.1 7.9e-32 109.4 0.1 1.3 1 0 0 1 1 1 1 PWI domain Toxin_3 PF00537.18 CCF35120.1 - 0.0033 17.6 7.5 0.0053 16.9 7.5 1.4 1 0 0 1 1 1 1 Scorpion toxin-like domain Gamma-thionin PF00304.20 CCF35120.1 - 0.044 14.1 9.8 0.045 14.0 8.8 1.5 1 1 0 1 1 1 0 Gamma-thionin family adh_short PF00106.25 CCF35121.1 - 7.4e-37 126.7 0.1 9.2e-37 126.4 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF35121.1 - 4.8e-25 88.5 0.1 6.5e-25 88.1 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF35121.1 - 4.4e-09 36.5 0.2 1.3e-08 35.0 0.2 1.7 1 1 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 CCF35121.1 - 0.00026 21.0 0.5 0.00048 20.1 0.3 1.5 2 0 0 2 2 2 1 NAD(P)H-binding MFS_1 PF07690.16 CCF35122.1 - 1.2e-38 133.0 53.3 1.7e-38 132.5 49.8 2.5 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 CCF35122.1 - 7.4e-11 41.2 18.0 1.2e-10 40.5 18.0 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.20 CCF35122.1 - 2.6 6.2 9.3 0.029 12.7 1.6 1.8 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family DHO_dh PF01180.21 CCF35123.1 - 5.1e-14 52.2 0.0 2.5e-13 49.9 0.0 1.8 1 1 0 1 1 1 1 Dihydroorotate dehydrogenase NMO PF03060.15 CCF35123.1 - 0.0069 15.8 1.6 0.011 15.1 1.6 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase MFS_1 PF07690.16 CCF35124.1 - 1.3e-11 44.0 46.8 6.5e-10 38.5 27.4 3.5 2 2 1 3 3 3 2 Major Facilitator Superfamily Glyco_transf_20 PF00982.21 CCF35125.1 - 4.4e-199 662.1 0.0 5e-199 661.9 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 20 Glyco_transf_5 PF08323.11 CCF35125.1 - 0.028 14.1 0.1 0.1 12.3 0.0 1.9 2 0 0 2 2 2 0 Starch synthase catalytic domain DEK_C PF08766.11 CCF35126.1 - 0.028 14.3 0.7 0.22 11.5 0.4 2.6 2 0 0 2 2 2 0 DEK C terminal domain PBP1_TM PF14812.6 CCF35126.1 - 0.033 14.5 6.2 0.033 14.5 6.2 5.2 2 2 4 6 6 6 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF4769 PF15992.5 CCF35126.1 - 0.89 9.3 2.9 0.97 9.2 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4769) HCNGP PF07818.13 CCF35127.1 - 1.2e-26 93.1 0.0 2.1e-26 92.4 0.0 1.4 1 0 0 1 1 1 1 HCNGP-like protein DEAD PF00270.29 CCF35128.1 - 4.2e-50 169.9 0.0 5.9e-49 166.2 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF35128.1 - 5.3e-26 91.2 0.0 1.4e-25 89.8 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-RING_5 PF14634.6 CCF35129.1 - 0.028 14.4 1.2 0.028 14.4 1.2 2.8 2 0 0 2 2 2 0 zinc-RING finger domain Autoind_bind PF03472.15 CCF35129.1 - 0.069 12.6 0.0 0.17 11.4 0.0 1.6 1 0 0 1 1 1 0 Autoinducer binding domain Zn_ribbon_17 PF17120.5 CCF35129.1 - 0.07 12.8 0.2 0.07 12.8 0.2 2.6 3 0 0 3 3 3 0 Zinc-ribbon, C4HC2 type zf-H2C2_2 PF13465.6 CCF35129.1 - 0.86 10.1 3.3 5.2 7.7 3.3 2.4 1 0 0 1 1 1 0 Zinc-finger double domain zf-RING_2 PF13639.6 CCF35129.1 - 5.2 7.5 17.0 0.054 13.8 3.7 3.4 3 1 0 3 3 3 0 Ring finger domain WD40 PF00400.32 CCF35130.1 - 2.4e-58 192.7 18.9 3.1e-10 40.4 0.6 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF35130.1 - 3.3e-26 91.4 0.0 7.8e-06 26.1 0.0 7.0 3 3 4 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CCF35130.1 - 3e-10 39.6 0.5 0.17 10.8 0.0 5.3 2 2 2 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 CCF35130.1 - 6.1e-06 25.2 1.4 0.37 9.4 0.1 4.5 2 2 2 5 5 5 2 Nucleoporin Nup120/160 eIF2A PF08662.11 CCF35130.1 - 9.9e-06 25.6 0.0 0.0087 15.9 0.0 2.6 3 0 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A VID27 PF08553.10 CCF35130.1 - 4.1e-05 22.8 0.0 1.6 7.7 0.0 4.6 2 2 2 5 5 5 1 VID27 C-terminal WD40-like domain Cytochrom_D1 PF02239.16 CCF35130.1 - 0.00014 20.5 0.0 0.0085 14.7 0.0 2.5 2 1 1 3 3 3 1 Cytochrome D1 heme domain Nucleoporin_N PF08801.11 CCF35130.1 - 0.0021 16.9 0.0 0.13 11.0 0.0 2.9 2 1 1 3 3 3 1 Nup133 N terminal like Frtz PF11768.8 CCF35130.1 - 0.0036 15.7 0.0 0.21 9.8 0.0 2.4 2 0 0 2 2 2 1 WD repeat-containing and planar cell polarity effector protein Fritz Ribosomal_60s PF00428.19 CCF35130.1 - 0.0068 17.0 12.2 0.028 15.0 2.8 2.7 2 0 0 2 2 2 1 60s Acidic ribosomal protein PALB2_WD40 PF16756.5 CCF35130.1 - 0.015 14.3 1.6 6.7 5.5 0.0 3.3 3 1 1 4 4 4 0 Partner and localizer of BRCA2 WD40 domain WD40_like PF17005.5 CCF35130.1 - 0.26 10.6 0.0 0.53 9.5 0.0 1.4 1 0 0 1 1 1 0 WD40-like domain Corona_nucleoca PF00937.18 CCF35130.1 - 3.1 6.7 15.1 5.1 6.0 15.1 1.3 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein Zn_clus PF00172.18 CCF35131.1 - 1.8e-08 34.4 10.9 2.8e-08 33.7 10.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CCF35131.1 - 3.4e-07 29.6 0.9 4.8e-07 29.1 0.9 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Mito_fiss_reg PF05308.11 CCF35131.1 - 0.32 11.0 4.3 0.49 10.4 4.3 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator DUF1772 PF08592.11 CCF35132.1 - 2.8e-18 66.6 0.0 4.2e-18 66.0 0.0 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF1772) SpoIISB_antitox PF14185.6 CCF35132.1 - 0.0029 17.4 0.1 0.0052 16.6 0.1 1.4 1 0 0 1 1 1 1 Antitoxin SpoIISB, type II toxin-antitoxin system ATG22 PF11700.8 CCF35133.1 - 0.0012 17.6 1.1 0.0013 17.4 1.1 1.1 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like DUF2306 PF10067.9 CCF35133.1 - 0.0036 17.5 0.8 0.0044 17.2 0.8 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2306) RTA1 PF04479.13 CCF35133.1 - 0.041 13.5 2.0 0.051 13.2 2.0 1.1 1 0 0 1 1 1 0 RTA1 like protein DUF4293 PF14126.6 CCF35133.1 - 0.045 14.0 3.5 0.05 13.9 3.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4293) OST3_OST6 PF04756.13 CCF35133.1 - 0.066 12.6 1.0 0.069 12.5 1.0 1.1 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family TMEM43 PF07787.12 CCF35133.1 - 2.4 7.5 3.6 2.7 7.3 3.6 1.0 1 0 0 1 1 1 0 Transmembrane protein 43 DUF5527 PF17665.1 CCF35133.1 - 7 6.2 9.4 10 5.7 9.0 1.6 1 1 1 2 2 2 0 Family of unknown function (DUF5527) SpoIIE PF07228.12 CCF35135.1 - 2.1e-05 24.6 0.0 8.8e-05 22.5 0.0 1.9 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 CCF35135.1 - 0.00048 19.8 0.1 0.00078 19.1 0.1 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C PF00481.21 CCF35135.1 - 0.014 15.1 0.0 0.39 10.3 0.0 2.1 2 0 0 2 2 2 0 Protein phosphatase 2C Fcf1 PF04900.12 CCF35136.1 - 6.4e-31 106.7 0.2 9.3e-31 106.2 0.2 1.2 1 0 0 1 1 1 1 Fcf1 C2 PF00168.30 CCF35137.1 - 1.3e-10 41.5 0.0 2.2e-10 40.7 0.0 1.4 1 0 0 1 1 1 1 C2 domain Oxidored_FMN PF00724.20 CCF35138.1 - 7.7e-66 222.7 0.0 8.9e-66 222.5 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Dus PF01207.17 CCF35138.1 - 0.053 12.6 0.2 0.1 11.7 0.0 1.7 2 1 0 2 2 2 0 Dihydrouridine synthase (Dus) DAO PF01266.24 CCF35139.1 - 6.5e-38 131.2 0.5 7.4e-38 131.0 0.5 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CCF35139.1 - 0.00039 20.6 0.1 0.0009 19.4 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CCF35139.1 - 0.00082 18.7 0.0 0.47 9.6 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CCF35139.1 - 0.0019 18.2 0.1 0.81 9.7 0.0 2.4 2 0 0 2 2 2 2 FAD-NAD(P)-binding Pyr_redox PF00070.27 CCF35139.1 - 0.0091 16.5 0.0 0.1 13.2 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CCF35139.1 - 0.028 13.5 0.0 0.11 11.6 0.0 1.9 2 0 0 2 2 2 0 FAD binding domain Sacchrp_dh_NADP PF03435.18 CCF35139.1 - 0.052 13.8 0.0 0.11 12.8 0.0 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain TrkA_N PF02254.18 CCF35139.1 - 0.069 13.4 0.0 0.15 12.3 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain GIDA PF01134.22 CCF35139.1 - 0.073 12.1 0.3 0.27 10.3 0.0 1.8 2 0 0 2 2 2 0 Glucose inhibited division protein A ApbA PF02558.16 CCF35139.1 - 0.098 12.3 0.0 0.17 11.5 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Ldh_1_N PF00056.23 CCF35139.1 - 0.12 12.4 0.0 0.22 11.6 0.0 1.4 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain Questin_oxidase PF14027.6 CCF35140.1 - 1.2e-93 314.3 3.5 1.5e-93 314.0 3.5 1.1 1 0 0 1 1 1 1 Questin oxidase-like Rad17 PF03215.15 CCF35141.1 - 1.9e-25 89.9 0.0 3.2e-25 89.2 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_16 PF13191.6 CCF35141.1 - 0.0012 19.3 0.0 0.0027 18.1 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 CCF35141.1 - 0.0023 18.3 0.0 0.0076 16.7 0.0 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 CCF35141.1 - 0.0055 16.7 0.0 0.011 15.8 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_30 PF13604.6 CCF35141.1 - 0.029 14.1 0.0 0.056 13.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 CCF35141.1 - 0.066 12.3 0.0 0.12 11.4 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_33 PF13671.6 CCF35141.1 - 0.15 12.3 0.0 0.38 10.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain Cupin_3 PF05899.12 CCF35142.1 - 0.0058 16.3 0.0 0.07 12.8 0.0 2.2 2 1 0 2 2 2 1 Protein of unknown function (DUF861) zf-C2H2 PF00096.26 CCF35144.1 - 0.17 12.4 0.2 0.49 11.0 0.2 1.9 1 0 0 1 1 1 0 Zinc finger, C2H2 type Slu7 PF11708.8 CCF35144.1 - 0.38 10.5 9.0 2.2 8.0 6.1 2.2 2 0 0 2 2 2 0 Pre-mRNA splicing Prp18-interacting factor TAF4 PF05236.14 CCF35144.1 - 0.83 9.3 10.0 0.029 14.1 4.0 1.6 2 0 0 2 2 2 0 Transcription initiation factor TFIID component TAF4 family FOXP-CC PF16159.5 CCF35144.1 - 0.91 10.2 3.8 0.44 11.2 1.0 1.9 2 0 0 2 2 2 0 FOXP coiled-coil domain YabA PF06156.13 CCF35144.1 - 6.8 7.4 6.2 4.3 8.0 0.2 2.3 1 1 1 2 2 2 0 Initiation control protein YabA Sulfatase PF00884.23 CCF35145.1 - 2.6e-57 194.6 0.0 3.3e-57 194.2 0.0 1.1 1 0 0 1 1 1 1 Sulfatase Choline_sulf_C PF12411.8 CCF35145.1 - 3.6e-26 90.7 1.1 3.6e-26 90.7 1.1 2.6 3 0 0 3 3 3 1 Choline sulfatase enzyme C terminal Phosphodiest PF01663.22 CCF35145.1 - 2.8e-09 37.1 0.0 0.0012 18.5 0.0 2.3 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase DUF4976 PF16347.5 CCF35145.1 - 0.0011 19.2 0.0 0.0022 18.2 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4976) DUF229 PF02995.17 CCF35145.1 - 0.088 11.4 0.0 0.13 10.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF229) CDI PF02234.19 CCF35145.1 - 0.19 12.0 1.3 1.2 9.4 0.1 2.6 2 0 0 2 2 2 0 Cyclin-dependent kinase inhibitor Med8 PF10232.9 CCF35146.1 - 7.2e-36 123.9 0.0 9.8e-36 123.5 0.0 1.2 1 0 0 1 1 1 1 Mediator of RNA polymerase II transcription complex subunit 8 baeRF_family3 PF18845.1 CCF35146.1 - 0.16 12.2 2.4 0.17 12.2 0.0 1.9 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 3 Fungal_trans PF04082.18 CCF35147.1 - 0.041 12.9 0.0 0.048 12.7 0.0 1.1 1 0 0 1 1 1 0 Fungal specific transcription factor domain Cation_ATPase_C PF00689.21 CCF35148.1 - 1.7e-46 158.2 5.5 1.7e-46 158.2 5.5 2.0 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 CCF35148.1 - 1.6e-35 122.3 0.4 1.6e-35 122.3 0.4 2.4 2 1 0 2 2 2 1 E1-E2 ATPase Cation_ATPase PF13246.6 CCF35148.1 - 3.2e-22 78.4 0.0 5.9e-22 77.6 0.0 1.4 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 CCF35148.1 - 1.6e-19 71.0 3.1 8.6e-19 68.7 3.1 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 CCF35148.1 - 5.7e-11 41.9 0.0 2.1e-09 36.9 0.0 2.9 3 0 0 3 3 3 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 CCF35148.1 - 4.7e-05 23.3 0.4 0.00084 19.2 0.2 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Pox_T4_N PF04491.12 CCF35148.1 - 0.039 13.8 0.0 0.076 12.9 0.0 1.5 1 0 0 1 1 1 0 Poxvirus T4 protein, N terminus Zn_clus PF00172.18 CCF35149.1 - 1.1e-07 31.9 14.3 2.2e-07 30.9 14.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 CCF35149.1 - 4e-05 22.6 0.2 5.5e-05 22.2 0.2 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain RTA1 PF04479.13 CCF35150.1 - 1.2e-67 227.5 12.4 1.7e-67 227.1 12.4 1.2 1 0 0 1 1 1 1 RTA1 like protein zf-C2H2_4 PF13894.6 CCF35154.1 - 2.5e-07 31.0 2.0 0.013 16.3 0.1 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 CCF35154.1 - 7.5e-06 26.1 2.8 0.037 14.5 0.1 2.4 2 0 0 2 2 2 2 Zinc finger, C2H2 type Axin_b-cat_bind PF08833.10 CCF35154.1 - 0.018 15.1 0.1 0.057 13.5 0.1 1.9 1 0 0 1 1 1 0 Axin beta-catenin binding domain zf-Di19 PF05605.12 CCF35154.1 - 0.23 11.8 1.2 6.4 7.2 0.8 2.2 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Glyco_hydro_115 PF15979.5 CCF35155.1 - 1.9e-135 451.7 1.5 1.9e-135 451.7 1.5 1.7 2 0 0 2 2 2 1 Glycosyl hydrolase family 115 GH115_C PF17829.1 CCF35155.1 - 1.3e-51 174.8 0.1 2.9e-51 173.7 0.1 1.6 1 0 0 1 1 1 1 Gylcosyl hydrolase family 115 C-terminal domain Kinesin PF00225.23 CCF35156.1 - 5.3e-117 390.5 0.0 7.1e-117 390.0 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 CCF35156.1 - 1.7e-28 99.4 0.0 3.4e-28 98.5 0.0 1.5 1 0 0 1 1 1 1 Microtubule binding Herpes_UL14 PF03580.14 CCF35156.1 - 0.0028 17.9 2.0 0.0083 16.4 2.0 1.8 1 0 0 1 1 1 1 Herpesvirus UL14-like protein NmrA PF05368.13 CCF35157.1 - 1.3e-65 221.2 0.0 1.6e-65 221.0 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CCF35157.1 - 1.4e-20 74.0 0.0 2.3e-20 73.3 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 CCF35157.1 - 3.6e-06 26.2 0.1 5.7e-06 25.5 0.1 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 CCF35157.1 - 0.00038 20.0 0.0 0.00068 19.2 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family TrkA_N PF02254.18 CCF35157.1 - 0.054 13.8 0.2 0.13 12.5 0.1 1.7 2 0 0 2 2 2 0 TrkA-N domain Sacchrp_dh_NADP PF03435.18 CCF35157.1 - 0.11 12.8 0.1 0.23 11.7 0.1 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Troponin-I_N PF11636.8 CCF35158.1 - 0.45 10.5 0.1 0.45 10.5 0.1 1.9 2 0 0 2 2 2 0 Troponin I residues 1-32 DUF2401 PF10287.9 CCF35159.1 - 3.7e-85 285.2 0.0 5.1e-85 284.7 0.0 1.2 1 0 0 1 1 1 1 Putative TOS1-like glycosyl hydrolase (DUF2401) DUF2403 PF10290.9 CCF35159.1 - 8.7e-22 77.3 0.0 2.3e-21 76.0 0.0 1.8 1 0 0 1 1 1 1 Glycine-rich protein domain (DUF2403) TALPID3 PF15324.6 CCF35159.1 - 0.94 7.1 4.7 1.3 6.6 4.7 1.2 1 0 0 1 1 1 0 Hedgehog signalling target SelP_N PF04592.14 CCF35159.1 - 9.6 5.5 10.1 15 4.9 10.1 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Rap_GAP PF02145.15 CCF35162.1 - 2.7e-54 183.5 0.0 4.9e-54 182.7 0.0 1.4 1 0 0 1 1 1 1 Rap/ran-GAP Tuberin PF03542.16 CCF35162.1 - 7.2e-39 133.9 4.9 6.5e-35 120.9 0.5 3.1 3 0 0 3 3 3 3 Tuberin SGL PF08450.12 CCF35163.1 - 1.7e-23 83.5 0.1 2.4e-23 83.0 0.1 1.2 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Str_synth PF03088.16 CCF35163.1 - 2.5e-05 24.3 0.0 7e-05 22.9 0.0 1.8 1 1 0 1 1 1 1 Strictosidine synthase Arylesterase PF01731.20 CCF35163.1 - 0.00024 21.2 0.0 0.00069 19.8 0.0 1.8 1 0 0 1 1 1 1 Arylesterase Proteasome_A_N PF10584.9 CCF35164.1 - 0.0027 17.4 0.5 0.0086 15.7 0.0 2.2 3 0 0 3 3 3 1 Proteasome subunit A N-terminal signature PD40 PF07676.12 CCF35164.1 - 0.031 14.2 0.3 0.8 9.7 0.0 3.0 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat DUF1618 PF07762.14 CCF35164.1 - 4.4 7.9 6.4 3.6 8.2 3.8 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1618) Alpha-amylase PF00128.24 CCF35165.1 - 8.6e-118 393.7 1.3 1.2e-117 393.2 1.3 1.1 1 0 0 1 1 1 1 Alpha amylase, catalytic domain DUF3459 PF11941.8 CCF35165.1 - 0.00062 20.0 0.0 0.0012 19.1 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3459) Malt_amylase_C PF16657.5 CCF35165.1 - 0.0024 18.0 0.1 0.006 16.7 0.1 1.7 1 0 0 1 1 1 1 Maltogenic Amylase, C-terminal domain hDGE_amylase PF14701.6 CCF35165.1 - 0.026 13.7 0.1 0.044 12.9 0.1 1.3 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain DUF4328 PF14219.6 CCF35166.1 - 0.049 13.2 0.0 0.07 12.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4328) Herpes_gE PF02480.16 CCF35166.1 - 0.1 11.4 0.0 0.14 10.9 0.0 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E MHYT PF03707.16 CCF35166.1 - 0.44 10.7 3.3 0.67 10.2 2.8 1.5 1 1 0 1 1 1 0 Bacterial signalling protein N terminal repeat DUF2749 PF10907.8 CCF35166.1 - 0.98 9.6 3.4 1 9.6 1.9 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2749) Pkinase PF00069.25 CCF35169.1 - 2.3e-56 191.1 0.0 5.5e-51 173.4 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCF35169.1 - 2.2e-33 115.6 0.0 6.5e-32 110.8 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF35169.1 - 6.3e-05 22.4 0.0 0.00039 19.8 0.0 1.9 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 CCF35169.1 - 7.2e-05 22.8 0.0 0.00013 21.9 0.0 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CCF35169.1 - 0.00091 18.1 0.0 0.0021 16.9 0.0 1.5 2 0 0 2 2 2 1 Fungal protein kinase PDGLE PF13190.6 CCF35169.1 - 0.077 12.9 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 PDGLE domain Kdo PF06293.14 CCF35169.1 - 0.14 11.5 0.0 0.24 10.8 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Sybindin PF04099.12 CCF35170.1 - 3.5e-23 82.1 0.0 4.3e-23 81.8 0.0 1.1 1 0 0 1 1 1 1 Sybindin-like family CC2D2AN-C2 PF15625.6 CCF35170.1 - 0.12 12.1 0.0 0.15 11.8 0.0 1.1 1 0 0 1 1 1 0 CC2D2A N-terminal C2 domain Peroxin-3 PF04882.12 CCF35171.1 - 1.4e-170 568.4 0.0 1.6e-170 568.2 0.0 1.0 1 0 0 1 1 1 1 Peroxin-3 PI-PLC-X PF00388.19 CCF35172.1 - 2.2e-07 30.6 0.0 3.2e-07 30.0 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain Fungal_trans PF04082.18 CCF35173.1 - 8.3e-05 21.7 0.6 0.00023 20.3 0.0 2.0 2 0 0 2 2 2 1 Fungal specific transcription factor domain Spt20 PF12090.8 CCF35173.1 - 0.0041 16.8 25.6 0.056 13.1 10.9 2.2 2 0 0 2 2 2 2 Spt20 family DUF4834 PF16118.5 CCF35173.1 - 0.043 14.8 7.9 2.3 9.2 0.5 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) EPL1 PF10513.9 CCF35173.1 - 0.25 11.7 8.0 4.5 7.6 1.5 2.3 2 0 0 2 2 2 0 Enhancer of polycomb-like Peroxin-13_N PF04088.13 CCF35173.1 - 0.36 11.1 3.4 2.3 8.5 0.3 2.3 2 0 0 2 2 2 0 Peroxin 13, N-terminal region Pex14_N PF04695.13 CCF35173.1 - 0.59 10.8 16.3 1 10.0 4.3 2.5 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region MMR1 PF08505.10 CCF35173.1 - 0.86 9.8 11.3 1.6 8.9 1.1 2.2 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein MPM1 PF17234.2 CCF35173.1 - 1.7 8.9 11.6 1.1 9.5 3.1 2.2 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 CPSF100_C PF13299.6 CCF35173.1 - 2.1 8.5 5.1 19 5.4 1.0 2.2 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal ANAPC_CDC26 PF10471.9 CCF35173.1 - 3.6 8.5 29.3 6.9 7.6 8.1 2.8 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 Hydin_ADK PF17213.3 CCF35173.1 - 5 7.3 8.4 13 6.0 2.6 2.3 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain Presenilin PF01080.17 CCF35173.1 - 5.8 5.6 9.0 12 4.5 9.0 1.4 1 1 0 1 1 1 0 Presenilin Peptidase_S49_N PF08496.10 CCF35173.1 - 6 6.9 8.8 5.7 7.0 2.1 2.2 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Pkinase PF00069.25 CCF35174.1 - 9.6e-43 146.4 0.0 2.2e-41 142.0 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF35174.1 - 4.2e-27 95.1 0.0 6.7e-27 94.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CCF35174.1 - 0.0022 16.8 0.0 0.0036 16.1 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 CCF35174.1 - 0.07 12.5 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Abhydrolase_6 PF12697.7 CCF35175.1 - 3e-18 67.3 0.0 3.8e-18 66.9 0.0 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Get5_C PF18514.1 CCF35175.1 - 0.0081 15.9 0.5 2 8.2 0.1 3.4 3 0 0 3 3 3 1 Get5 C-terminal domain DUF900 PF05990.12 CCF35175.1 - 0.021 14.3 0.0 0.044 13.3 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) DUF676 PF05057.14 CCF35175.1 - 0.072 12.6 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Abhydrolase_8 PF06259.12 CCF35175.1 - 0.089 12.4 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase ADC PF06314.11 CCF35176.1 - 0.00011 21.9 0.0 0.00016 21.3 0.0 1.2 1 0 0 1 1 1 1 Acetoacetate decarboxylase (ADC) HET PF06985.11 CCF35177.1 - 2.7e-36 125.1 2.4 4.5e-36 124.4 2.4 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) WBS_methylT PF12589.8 CCF35178.1 - 3.6e-15 56.5 4.5 6.6e-15 55.6 4.5 1.5 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_11 PF08241.12 CCF35178.1 - 6.6e-12 45.9 0.0 1.3e-11 45.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF35178.1 - 4.7e-11 43.2 0.0 1.2e-10 41.9 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF35178.1 - 1.5e-05 25.6 0.0 5.3e-05 23.9 0.0 2.0 2 1 0 2 2 2 1 Methyltransferase domain PCMT PF01135.19 CCF35178.1 - 0.00025 20.9 0.0 0.00042 20.1 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 CCF35178.1 - 0.0011 18.7 0.0 0.0018 18.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF35178.1 - 0.0019 18.1 0.0 0.0027 17.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 CCF35178.1 - 0.0037 16.6 0.0 0.1 11.9 0.0 2.1 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.18 CCF35178.1 - 0.037 13.4 0.0 0.11 11.8 0.0 1.8 3 0 0 3 3 3 0 ubiE/COQ5 methyltransferase family Methyltransf_2 PF00891.18 CCF35178.1 - 0.071 12.4 0.0 0.13 11.5 0.0 1.4 1 0 0 1 1 1 0 O-methyltransferase domain DUF2264 PF10022.9 CCF35180.1 - 2e-128 428.4 0.9 2.6e-128 428.1 0.9 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2264) HMA PF00403.26 CCF35182.1 - 1.2e-12 48.1 0.1 2.1e-12 47.3 0.1 1.5 1 0 0 1 1 1 1 Heavy-metal-associated domain Sod_Cu PF00080.20 CCF35182.1 - 1e-07 32.2 0.0 1.7e-07 31.5 0.0 1.3 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) Chordopox_RPO7 PF05864.12 CCF35182.1 - 0.1 12.9 0.4 1.8 8.9 0.0 2.2 2 0 0 2 2 2 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) Ribosomal_L13 PF00572.18 CCF35183.1 - 2.1e-39 134.6 0.0 3.2e-39 134.0 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L13 Uricase PF01014.18 CCF35184.1 - 6.9e-81 269.0 0.2 2.4e-42 144.3 0.1 2.0 2 0 0 2 2 2 2 Uricase RICTOR_N PF14664.6 CCF35185.1 - 1.5e-128 428.9 4.4 3.3e-128 427.8 3.5 2.1 2 0 0 2 2 2 1 Rapamycin-insensitive companion of mTOR, N-term RICTOR_M PF14666.6 CCF35185.1 - 3.2e-37 126.5 0.0 6.9e-34 115.7 0.0 4.2 4 0 0 4 4 4 1 Rapamycin-insensitive companion of mTOR, middle domain RasGEF_N_2 PF14663.6 CCF35185.1 - 1e-36 125.6 0.4 2.4e-33 114.7 0.0 3.9 3 0 0 3 3 3 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain RICTOR_V PF14668.6 CCF35185.1 - 5.4e-31 106.7 0.2 4.3e-29 100.5 0.1 3.9 5 0 0 5 5 5 1 Rapamycin-insensitive companion of mTOR, domain 5 HR1 PF02185.16 CCF35185.1 - 8.5e-16 57.8 10.5 2.9e-15 56.1 10.5 1.9 1 0 0 1 1 1 1 Hr1 repeat ATG16 PF08614.11 CCF35185.1 - 0.0011 19.2 2.7 0.0042 17.3 2.7 2.0 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Uds1 PF15456.6 CCF35185.1 - 0.023 14.9 6.1 0.073 13.2 6.1 1.8 1 0 0 1 1 1 0 Up-regulated During Septation DUF4407 PF14362.6 CCF35185.1 - 0.3 10.4 3.5 0.7 9.2 3.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Methyltrn_RNA_4 PF09936.9 CCF35185.1 - 0.39 10.6 1.4 0.4 10.5 0.0 1.7 2 0 0 2 2 1 0 SAM-dependent RNA methyltransferase Mu-like_Pro PF10123.9 CCF35185.1 - 0.53 9.8 5.1 1.1 8.7 5.1 1.5 1 0 0 1 1 1 0 Mu-like prophage I protein CENP-B_dimeris PF09026.10 CCF35185.1 - 1 9.8 5.0 2.5 8.6 5.0 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Phos_pyr_kin PF08543.12 CCF35186.1 - 5.9e-86 287.8 0.6 6.7e-86 287.7 0.6 1.0 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.24 CCF35186.1 - 2.8e-10 40.0 0.0 2.4e-09 36.9 0.0 2.0 1 1 0 1 1 1 1 pfkB family carbohydrate kinase HK PF02110.15 CCF35186.1 - 0.069 12.5 1.4 0.43 9.9 0.0 2.3 3 0 0 3 3 3 0 Hydroxyethylthiazole kinase family Carb_kinase PF01256.17 CCF35186.1 - 0.1 12.1 3.1 0.37 10.2 3.1 2.1 1 1 0 1 1 1 0 Carbohydrate kinase NUFIP1 PF10453.9 CCF35187.1 - 3.6e-07 29.9 1.8 4e-07 29.8 0.0 1.9 2 0 0 2 2 2 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) zf_CCCH_4 PF18345.1 CCF35187.1 - 0.039 14.0 6.8 0.073 13.2 6.8 1.5 1 0 0 1 1 1 0 Zinc finger domain PIEZO PF15917.5 CCF35187.1 - 0.056 12.9 1.7 0.16 11.4 1.7 1.7 1 0 0 1 1 1 0 Piezo zf-CCCH PF00642.24 CCF35187.1 - 0.2 11.6 5.9 0.45 10.5 5.9 1.6 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RNA_pol_Rbc25 PF08292.12 CCF35188.1 - 6.3e-32 110.5 1.4 3.9e-31 108.0 1.4 1.9 1 1 0 1 1 1 1 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.17 CCF35188.1 - 6.2e-14 52.1 0.0 9.5e-14 51.5 0.0 1.3 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 EMC3_TMCO1 PF01956.16 CCF35189.1 - 1.1e-53 181.5 0.9 1.3e-53 181.2 0.9 1.1 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like SPC25 PF06703.11 CCF35190.1 - 9.2e-54 181.6 0.1 1.1e-53 181.4 0.1 1.1 1 0 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) Lactamase_B_2 PF12706.7 CCF35191.1 - 0.0001 21.9 0.0 0.00017 21.2 0.0 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 CCF35191.1 - 0.035 14.0 0.3 0.096 12.6 0.2 1.7 1 1 0 1 1 1 0 Beta-lactamase superfamily domain MFS_1 PF07690.16 CCF35192.1 - 3.5e-20 72.3 13.1 3.5e-20 72.3 13.1 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Polyketide_cyc PF03364.20 CCF35194.1 - 3.8e-27 95.0 0.1 9.8e-27 93.7 0.1 1.7 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc2 PF10604.9 CCF35194.1 - 9.5e-06 25.9 1.1 2.9e-05 24.4 1.1 1.7 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport SNF5 PF04855.12 CCF35197.1 - 8.3e-92 307.3 0.0 1.1e-91 306.9 0.0 1.1 1 0 0 1 1 1 1 SNF5 / SMARCB1 / INI1 GATA PF00320.27 CCF35197.1 - 0.0013 18.3 2.1 0.0034 17.0 2.1 1.8 1 0 0 1 1 1 1 GATA zinc finger HEAT PF02985.22 CCF35200.1 - 0.0064 16.7 2.1 0.8 10.1 0.3 4.7 5 0 0 5 5 5 1 HEAT repeat AA_permease PF00324.21 CCF35201.1 - 8.1e-98 328.1 31.0 9.1e-98 327.9 31.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CCF35201.1 - 1.1e-24 87.1 33.1 1.3e-24 86.8 33.1 1.0 1 0 0 1 1 1 1 Amino acid permease 2-Hacid_dh_C PF02826.19 CCF35202.1 - 3.6e-46 156.7 0.0 3.4e-33 114.5 0.0 2.1 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CCF35202.1 - 0.0012 18.5 0.0 0.0015 18.2 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 CCF35202.1 - 0.029 14.6 0.0 0.044 14.0 0.0 1.3 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase XdhC_C PF13478.6 CCF35202.1 - 0.16 12.5 0.0 0.27 11.8 0.0 1.5 1 0 0 1 1 1 0 XdhC Rossmann domain NUDIX PF00293.28 CCF35203.1 - 2.5e-10 40.5 0.0 2.9e-10 40.3 0.0 1.1 1 0 0 1 1 1 1 NUDIX domain YcxB PF14317.6 CCF35203.1 - 0.11 12.2 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 YcxB-like protein SRP-alpha_N PF04086.13 CCF35204.1 - 0.0098 15.9 11.3 0.013 15.5 11.3 1.1 1 0 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal SWIRM-assoc_2 PF16496.5 CCF35204.1 - 0.018 13.9 8.9 0.022 13.7 8.9 1.2 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal DUF936 PF06075.12 CCF35204.1 - 0.11 11.3 8.3 0.15 11.0 8.3 1.0 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) Vac7 PF12751.7 CCF35204.1 - 0.13 11.7 6.4 0.18 11.2 6.4 1.1 1 0 0 1 1 1 0 Vacuolar segregation subunit 7 NPR3 PF03666.13 CCF35204.1 - 0.14 10.9 6.7 0.15 10.8 6.7 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CDC45 PF02724.14 CCF35204.1 - 0.51 8.6 5.6 0.58 8.4 5.6 1.1 1 0 0 1 1 1 0 CDC45-like protein FAM60A PF15396.6 CCF35204.1 - 0.6 10.1 9.4 1.3 9.0 9.4 1.6 1 1 0 1 1 1 0 Protein Family FAM60A Zip PF02535.22 CCF35204.1 - 0.75 9.0 2.6 0.8 8.9 2.6 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Sec62 PF03839.16 CCF35204.1 - 2.8 7.4 8.2 4.1 6.9 8.2 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 Vfa1 PF08432.10 CCF35204.1 - 3.7 7.8 18.0 5.9 7.2 18.0 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 CCDC106 PF15794.5 CCF35204.1 - 6.3 6.4 15.3 9.7 5.8 15.3 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 PDR_CDR PF06422.12 CCF35205.1 - 0.0032 17.4 2.8 0.0051 16.7 2.8 1.4 1 1 0 1 1 1 1 CDR ABC transporter Chitin_synth_1 PF01644.17 CCF35206.1 - 2.3e-68 229.3 0.0 3.3e-68 228.8 0.0 1.2 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 CCF35206.1 - 1.9e-27 95.0 0.0 3.6e-27 94.1 0.0 1.5 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 CCF35206.1 - 1.3e-26 93.4 0.1 2.1e-21 76.2 0.0 2.3 2 0 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 CCF35206.1 - 1.5e-08 34.8 2.3 7.5e-08 32.5 2.3 2.3 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 CCF35206.1 - 0.025 14.4 0.0 0.053 13.4 0.0 1.5 1 0 0 1 1 1 0 Glycosyltransferase like family 2 Hist_deacetyl PF00850.19 CCF35208.1 - 3.3e-52 177.9 0.1 4.9e-52 177.3 0.1 1.3 1 0 0 1 1 1 1 Histone deacetylase domain RTP801_C PF07809.11 CCF35208.1 - 0.00064 19.6 0.0 0.0013 18.6 0.0 1.4 1 0 0 1 1 1 1 RTP801 C-terminal region TGT PF01702.18 CCF35209.1 - 4.8e-139 463.4 0.0 5.6e-139 463.1 0.0 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase Mit_ribos_Mrp51 PF11709.8 CCF35210.1 - 1.7e-128 429.3 0.0 2.1e-128 429.0 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit Ribosomal_S17e PF00833.18 CCF35211.1 - 1.2e-59 199.5 0.3 1.5e-59 199.2 0.3 1.0 1 0 0 1 1 1 1 Ribosomal S17 RPAP2_Rtr1 PF04181.13 CCF35212.1 - 1e-22 80.2 0.1 1.9e-22 79.3 0.1 1.5 1 0 0 1 1 1 1 Rtr1/RPAP2 family Arm-DNA-bind_3 PF13356.6 CCF35212.1 - 0.039 14.3 0.1 0.65 10.4 0.0 2.4 1 1 1 2 2 2 0 Arm DNA-binding domain SH3_1 PF00018.28 CCF35213.1 - 6.8e-09 35.2 0.1 1e-08 34.6 0.1 1.3 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 CCF35213.1 - 1.3e-07 31.2 0.0 2e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 CCF35213.1 - 6.2e-07 29.2 0.1 9.6e-07 28.6 0.1 1.3 1 0 0 1 1 1 1 Variant SH3 domain Luteo_Vpg PF01659.16 CCF35215.1 - 0.016 15.5 3.7 0.041 14.2 3.7 1.8 1 0 0 1 1 1 0 Luteovirus putative VPg genome linked protein p450 PF00067.22 CCF35216.1 - 5.5e-34 117.7 0.0 6.4e-34 117.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 RNA_pol_Rpb5_C PF01191.19 CCF35216.1 - 0.12 12.2 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 RNA polymerase Rpb5, C-terminal domain FSH1 PF03959.13 CCF35217.1 - 1.7e-27 96.5 0.0 2.1e-27 96.2 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) p450 PF00067.22 CCF35218.1 - 2.6e-51 174.8 0.0 3.1e-51 174.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 ketoacyl-synt PF00109.26 CCF35219.1 - 6.5e-74 248.7 0.1 8.5e-74 248.3 0.1 1.1 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Thiolase_N PF00108.23 CCF35219.1 - 3.8e-07 29.7 0.1 6.7e-07 28.9 0.1 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain Ketoacyl-synt_C PF02801.22 CCF35219.1 - 3e-05 24.0 0.0 6.8e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain ACP_syn_III PF08545.10 CCF35219.1 - 0.064 13.1 0.3 0.47 10.3 0.3 2.3 1 1 1 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III SET PF00856.28 CCF35220.1 - 2e-08 34.8 0.4 6.5e-08 33.1 0.2 2.0 2 1 0 2 2 2 1 SET domain RhoGAP-FF1 PF16512.5 CCF35220.1 - 0.01 16.5 1.4 0.13 13.0 0.1 2.3 2 0 0 2 2 2 0 p190-A and -B Rho GAPs FF domain PHD_like PF12910.7 CCF35220.1 - 0.22 11.5 0.6 0.54 10.3 0.1 1.9 2 0 0 2 2 2 0 Antitoxin of toxin-antitoxin, RelE / RelB, TA system FAM76 PF16046.5 CCF35220.1 - 0.37 10.1 6.6 0.045 13.1 1.6 1.9 2 0 0 2 2 2 0 FAM76 protein HypA PF01155.19 CCF35220.1 - 0.76 9.8 4.6 0.18 11.8 0.3 2.1 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Ribosomal_L14 PF00238.19 CCF35221.1 - 2.4e-45 153.6 3.0 2.8e-45 153.4 3.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e TFIIS_C PF01096.18 CCF35222.1 - 6.5e-17 61.1 3.1 7.1e-17 61.0 3.1 1.0 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Lar_restr_allev PF14354.6 CCF35222.1 - 0.0002 21.7 2.7 0.00022 21.5 2.7 1.0 1 0 0 1 1 1 1 Restriction alleviation protein Lar A2L_zn_ribbon PF08792.10 CCF35222.1 - 0.013 15.2 5.2 0.32 10.8 2.6 2.2 2 0 0 2 2 2 0 A2L zinc ribbon domain Zn-ribbon_8 PF09723.10 CCF35222.1 - 0.87 9.8 9.0 6 7.1 2.9 2.3 2 0 0 2 2 2 0 Zinc ribbon domain IF-2B PF01008.17 CCF35223.1 - 1.5e-42 145.8 0.0 1.7e-42 145.6 0.0 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family TRAPPC10 PF12584.8 CCF35224.1 - 7.3e-25 87.5 0.0 1.4e-24 86.5 0.0 1.5 1 0 0 1 1 1 1 Trafficking protein particle complex subunit 10, TRAPPC10 Foie-gras_1 PF11817.8 CCF35224.1 - 0.034 13.8 0.1 0.054 13.1 0.1 1.3 1 0 0 1 1 1 0 Foie gras liver health family 1 Mito_carr PF00153.27 CCF35226.1 - 3.7e-05 23.6 0.1 4.5e-05 23.3 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial carrier protein DUF1145 PF06611.12 CCF35229.1 - 0.091 12.7 0.0 0.16 12.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1145) SUR7 PF06687.12 CCF35231.1 - 1.7e-30 106.3 14.8 2.1e-30 105.9 14.8 1.1 1 0 0 1 1 1 1 SUR7/PalI family Bacillus_PapR PF05968.11 CCF35231.1 - 0.078 12.9 0.5 0.078 12.9 0.5 2.1 2 0 0 2 2 2 0 Bacillus PapR protein DUF4834 PF16118.5 CCF35231.1 - 0.3 12.1 3.4 5.7 8.0 0.0 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) CD20 PF04103.15 CCF35231.1 - 6.2 6.9 17.7 0.46 10.6 7.9 2.9 3 0 0 3 3 3 0 CD20-like family GST_N_3 PF13417.6 CCF35233.1 - 2e-17 63.3 0.0 4.4e-17 62.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CCF35233.1 - 6.1e-16 58.5 0.1 1.5e-15 57.2 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CCF35233.1 - 1.5e-08 34.6 0.1 3.2e-08 33.5 0.1 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 CCF35233.1 - 2.9e-06 27.5 0.1 5.5e-06 26.6 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 CCF35233.1 - 0.0014 18.8 0.0 0.0028 17.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 CCF35233.1 - 0.0027 18.2 0.0 0.0051 17.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 CCF35233.1 - 0.0085 16.3 0.0 0.016 15.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain DUF4328 PF14219.6 CCF35233.1 - 0.19 11.3 0.0 0.31 10.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4328) Pro_dh PF01619.18 CCF35234.1 - 6.7e-62 209.7 0.0 7.8e-62 209.5 0.0 1.1 1 0 0 1 1 1 1 Proline dehydrogenase P5CR_dimer PF14748.6 CCF35235.1 - 1.1e-28 99.4 0.6 3e-28 98.1 0.6 1.7 1 0 0 1 1 1 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 CCF35235.1 - 2.6e-10 40.7 0.1 5.6e-10 39.7 0.1 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Pkinase PF00069.25 CCF35236.1 - 7e-06 25.6 0.0 7e-06 25.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain ABC1 PF03109.16 CCF35236.1 - 0.0015 18.6 0.1 0.0017 18.5 0.1 1.2 1 1 0 1 1 1 1 ABC1 family Pkinase_Tyr PF07714.17 CCF35236.1 - 0.0051 16.1 0.0 0.0051 16.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase MFS_1 PF07690.16 CCF35238.1 - 5.4e-24 84.8 16.7 5.4e-24 84.8 16.7 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF35238.1 - 1.4e-07 30.8 20.3 0.0008 18.4 1.0 3.3 2 1 1 3 3 3 3 Sugar (and other) transporter DUF5389 PF17364.2 CCF35238.1 - 0.019 15.0 2.8 0.024 14.7 0.3 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5389) Condensation PF00668.20 CCF35240.1 - 1.7e-86 290.7 0.0 2.6e-86 290.1 0.0 1.2 1 0 0 1 1 1 1 Condensation domain AMP-binding PF00501.28 CCF35240.1 - 1.2e-73 248.1 0.0 8e-56 189.4 0.0 2.2 2 0 0 2 2 2 2 AMP-binding enzyme PP-binding PF00550.25 CCF35240.1 - 7.8e-14 51.8 0.2 2.3e-13 50.3 0.2 1.9 1 0 0 1 1 1 1 Phosphopantetheine attachment site AMP-binding_C PF13193.6 CCF35240.1 - 9e-10 39.4 0.2 0.00029 21.8 0.0 3.3 2 0 0 2 2 2 2 AMP-binding enzyme C-terminal domain Methyltransf_23 PF13489.6 CCF35240.1 - 0.0013 18.6 0.0 0.0039 17.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF35240.1 - 0.12 13.2 0.5 0.76 10.6 0.2 2.6 2 1 0 2 2 2 0 Methyltransferase domain Methyltransf_25 PF13649.6 CCF35240.1 - 0.17 12.6 0.0 0.77 10.5 0.0 2.2 1 0 0 1 1 1 0 Methyltransferase domain Condensation PF00668.20 CCF35241.1 - 3.7e-266 883.0 0.0 1.2e-90 304.4 0.0 3.2 3 0 0 3 3 3 3 Condensation domain AMP-binding PF00501.28 CCF35241.1 - 1.5e-231 768.4 9.6 1.5e-76 257.7 0.0 5.3 4 1 1 5 5 5 5 AMP-binding enzyme PP-binding PF00550.25 CCF35241.1 - 2.7e-38 130.1 2.5 1.8e-11 44.2 0.0 4.1 3 0 0 3 3 3 3 Phosphopantetheine attachment site AMP-binding_C PF13193.6 CCF35241.1 - 1.4e-34 118.9 7.2 1.1e-12 48.8 0.4 5.0 4 0 0 4 4 4 3 AMP-binding enzyme C-terminal domain Nop PF01798.18 CCF35242.1 - 2.8e-73 246.2 0.0 4e-73 245.7 0.0 1.2 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin Prp31_C PF09785.9 CCF35242.1 - 3.9e-47 160.1 4.8 6.8e-47 159.3 2.2 2.3 2 0 0 2 2 2 1 Prp31 C terminal domain RRN3 PF05327.11 CCF35242.1 - 0.26 9.8 2.9 0.49 8.9 2.9 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 HAT PF02184.16 CCF35243.1 - 1.8e-22 79.0 76.5 2e-12 46.9 2.2 12.8 15 0 0 15 15 14 5 HAT (Half-A-TPR) repeat TPR_14 PF13428.6 CCF35243.1 - 3e-22 77.4 36.8 2.6e-05 24.7 0.2 11.2 9 3 3 12 12 11 6 Tetratricopeptide repeat Suf PF05843.14 CCF35243.1 - 1.4e-18 67.9 20.3 2.1e-05 24.7 0.1 6.2 3 1 3 6 6 6 5 Suppressor of forked protein (Suf) TPR_19 PF14559.6 CCF35243.1 - 9.6e-17 61.3 6.3 6.1e-05 23.5 0.0 6.8 6 1 2 8 8 7 2 Tetratricopeptide repeat TPR_15 PF13429.6 CCF35243.1 - 3.4e-07 29.8 15.0 0.32 10.2 0.5 6.1 2 1 2 5 5 5 4 Tetratricopeptide repeat TPR_16 PF13432.6 CCF35243.1 - 2.7e-05 24.7 24.2 0.31 11.7 0.1 8.1 8 1 2 10 10 9 3 Tetratricopeptide repeat TPR_17 PF13431.6 CCF35243.1 - 7.2e-05 22.9 12.5 4.4 7.9 0.0 7.5 9 0 0 9 9 7 2 Tetratricopeptide repeat TPR_2 PF07719.17 CCF35243.1 - 8.1e-05 22.5 26.5 0.049 13.8 0.1 9.0 10 0 0 10 10 10 2 Tetratricopeptide repeat TPR_8 PF13181.6 CCF35243.1 - 0.00013 21.9 9.6 0.49 10.7 0.0 7.1 8 0 0 8 8 6 1 Tetratricopeptide repeat ANAPC3 PF12895.7 CCF35243.1 - 0.00051 20.2 2.9 8.3 6.7 0.0 5.3 5 0 0 5 5 5 1 Anaphase-promoting complex, cyclosome, subunit 3 U3_assoc_6 PF08640.11 CCF35243.1 - 0.00096 19.2 26.3 0.074 13.1 0.4 7.0 5 3 3 8 8 8 2 U3 small nucleolar RNA-associated protein 6 TPR_6 PF13174.6 CCF35243.1 - 0.0012 19.3 27.5 2.1 9.2 0.0 8.4 9 2 1 10 10 8 1 Tetratricopeptide repeat NRDE-2 PF08424.10 CCF35243.1 - 0.0017 17.5 22.1 1.2 8.2 2.5 5.9 4 3 1 5 5 5 3 NRDE-2, necessary for RNA interference BSD PF03909.17 CCF35243.1 - 0.019 15.0 0.1 0.084 12.9 0.1 2.2 1 0 0 1 1 1 0 BSD domain Fis1_TPR_C PF14853.6 CCF35243.1 - 0.022 14.8 11.4 15 5.7 0.8 5.9 7 0 0 7 7 6 0 Fis1 C-terminal tetratricopeptide repeat TPR_9 PF13371.6 CCF35243.1 - 0.063 13.4 14.4 1.4 9.2 0.0 5.3 6 1 0 6 6 6 0 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 CCF35243.1 - 0.07 13.1 21.5 2.6 8.1 0.0 6.8 5 2 2 7 7 7 0 Mad3/BUB1 homology region 1 TPR_1 PF00515.28 CCF35243.1 - 0.15 11.9 8.4 14 5.7 0.0 5.0 6 0 0 6 6 4 0 Tetratricopeptide repeat c-SKI_SMAD_bind PF08782.10 CCF35243.1 - 3.4 8.0 6.5 2.6 8.3 0.1 3.7 4 0 0 4 4 3 0 c-SKI Smad4 binding domain La PF05383.17 CCF35246.1 - 3.5e-16 59.0 0.0 5.6e-16 58.3 0.0 1.3 1 0 0 1 1 1 1 La domain peroxidase PF00141.23 CCF35248.1 - 9.2e-29 100.8 0.0 1.5e-28 100.1 0.0 1.3 1 0 0 1 1 1 1 Peroxidase Abhydrolase_3 PF07859.13 CCF35249.1 - 1.4e-40 139.4 0.0 1.2e-30 107.0 0.0 2.7 2 0 0 2 2 2 2 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 CCF35249.1 - 6.2e-14 51.6 0.0 1.3e-13 50.6 0.0 1.4 1 0 0 1 1 1 1 Steryl acetyl hydrolase COesterase PF00135.28 CCF35249.1 - 0.0032 16.4 0.1 0.048 12.5 0.0 2.1 2 0 0 2 2 2 1 Carboxylesterase family WGG PF10273.9 CCF35250.1 - 4e-33 113.9 1.0 8.4e-33 112.9 0.1 1.8 2 0 0 2 2 2 1 Pre-rRNA-processing protein TSR2 RRP7 PF12923.7 CCF35250.1 - 0.013 15.7 1.0 0.027 14.6 0.1 1.9 2 0 0 2 2 2 0 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain Astro_capsid_p PF12226.8 CCF35250.1 - 0.99 8.5 5.3 1.1 8.4 5.3 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein BSD PF03909.17 CCF35251.1 - 9.7e-20 70.3 0.2 1.9e-19 69.4 0.2 1.5 1 0 0 1 1 1 1 BSD domain Sigma70_r2 PF04542.14 CCF35251.1 - 0.0078 16.0 0.5 0.02 14.6 0.0 1.9 2 0 0 2 2 2 1 Sigma-70 region 2 zinc_ribbon_10 PF10058.9 CCF35253.1 - 0.17 11.6 0.1 0.31 10.8 0.1 1.4 1 0 0 1 1 1 0 Predicted integral membrane zinc-ribbon metal-binding protein E1-E2_ATPase PF00122.20 CCF35254.1 - 1.3e-47 161.7 5.9 1.3e-47 161.7 5.9 2.8 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 CCF35254.1 - 8.9e-28 98.0 1.0 2e-27 96.9 1.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 CCF35254.1 - 2.8e-11 43.7 0.1 1.8e-09 37.9 0.0 2.7 2 0 0 2 2 2 1 Heavy-metal-associated domain HAD PF12710.7 CCF35254.1 - 0.036 14.5 0.0 0.096 13.1 0.0 1.7 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 CCF35254.1 - 0.24 11.1 0.7 13 5.4 0.2 2.3 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Peptidase_M24 PF00557.24 CCF35255.1 - 0.18 11.4 0.0 0.25 11.0 0.0 1.2 1 0 0 1 1 1 0 Metallopeptidase family M24 PT PF04886.12 CCF35256.1 - 0.0027 17.2 8.0 0.0066 16.0 8.0 1.7 1 0 0 1 1 1 1 PT repeat ORC6 PF05460.13 CCF35256.1 - 0.0057 16.0 4.0 0.007 15.7 4.0 1.2 1 0 0 1 1 1 1 Origin recognition complex subunit 6 (ORC6) HTH_WhiA PF02650.14 CCF35256.1 - 0.037 14.4 0.0 0.098 13.0 0.0 1.8 1 0 0 1 1 1 0 WhiA C-terminal HTH domain PQ-loop PF04193.14 CCF35257.1 - 7.5e-17 60.9 3.9 1.1e-11 44.4 0.8 2.7 2 0 0 2 2 2 2 PQ loop repeat DUF92 PF01940.16 CCF35257.1 - 0.017 14.6 0.0 0.032 13.7 0.0 1.4 1 0 0 1 1 1 0 Integral membrane protein DUF92 MLVIN_C PF18697.1 CCF35258.1 - 0.0052 16.8 0.2 0.0081 16.2 0.2 1.3 1 1 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain Rep_2 PF01719.17 CCF35258.1 - 0.029 14.1 0.1 0.034 13.9 0.1 1.1 1 0 0 1 1 1 0 Plasmid replication protein SH3_1 PF00018.28 CCF35259.1 - 4.9e-16 58.1 0.1 9.6e-16 57.1 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 CCF35259.1 - 1e-14 54.1 0.2 2.2e-14 53.0 0.2 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 CCF35259.1 - 6.4e-14 51.4 0.1 1.5e-13 50.2 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain WW PF00397.26 CCF35259.1 - 0.021 14.9 0.0 0.05 13.7 0.0 1.6 1 0 0 1 1 1 0 WW domain CFEM PF05730.11 CCF35264.1 - 1.3e-09 38.0 7.9 1.8e-09 37.6 7.9 1.2 1 0 0 1 1 1 1 CFEM domain Peroxidase_2 PF01328.17 CCF35265.1 - 2e-53 181.7 0.0 2.4e-53 181.4 0.0 1.0 1 0 0 1 1 1 1 Peroxidase, family 2 Clat_adaptor_s PF01217.20 CCF35266.1 - 2.9e-05 24.0 0.0 3e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 Clathrin adaptor complex small chain DUF4536 PF15055.6 CCF35267.1 - 9.2e-07 29.0 3.4 1.4e-06 28.4 3.4 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4536) ECR1_N PF14382.6 CCF35268.1 - 2e-16 59.5 2.6 3.9e-16 58.6 2.6 1.5 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region KH_6 PF15985.5 CCF35268.1 - 0.0006 20.1 0.0 0.0012 19.2 0.0 1.5 1 0 0 1 1 1 1 KH domain EXOSC1 PF10447.9 CCF35268.1 - 0.03 14.9 1.3 0.61 10.7 0.1 2.9 2 1 1 3 3 3 0 Exosome component EXOSC1/CSL4 Aldo_ket_red PF00248.21 CCF35269.1 - 2.5e-08 33.5 0.0 3.6e-08 33.0 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Clat_adaptor_s PF01217.20 CCF35270.1 - 6.1e-43 146.2 1.3 6.7e-43 146.0 1.3 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Glyco_hydro_18 PF00704.28 CCF35271.1 - 3.3e-59 201.2 0.1 6e-59 200.3 0.1 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Beta_helix PF13229.6 CCF35272.1 - 0.00062 19.6 22.7 0.0097 15.8 14.3 2.4 1 1 1 2 2 2 2 Right handed beta helix region Mpv17_PMP22 PF04117.12 CCF35273.1 - 2.4e-12 46.9 5.5 5.3e-12 45.8 5.0 1.8 1 1 0 1 1 1 1 Mpv17 / PMP22 family CFEM PF05730.11 CCF35274.1 - 1.4e-09 37.9 3.7 2.4e-09 37.2 3.7 1.4 1 0 0 1 1 1 1 CFEM domain DUF3439 PF11921.8 CCF35274.1 - 2.1 8.3 9.8 1.9 8.5 3.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) CENP-I PF07778.11 CCF35276.1 - 0.26 9.9 3.0 0.33 9.6 3.0 1.1 1 0 0 1 1 1 0 Mis6 DUF4407 PF14362.6 CCF35276.1 - 0.99 8.7 8.4 1.3 8.3 8.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Ac76 PF05814.11 CCF35276.1 - 2.9 7.9 5.6 4.1 7.5 1.9 2.4 1 1 1 2 2 2 0 Orf76 (Ac76) UCR_14kD PF02271.16 CCF35277.1 - 5.9e-43 144.9 0.0 7e-43 144.7 0.0 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex 14kD subunit Anp1 PF03452.14 CCF35278.1 - 8.5e-106 353.2 0.0 1e-105 352.9 0.0 1.1 1 0 0 1 1 1 1 Anp1 DUF3328 PF11807.8 CCF35278.1 - 0.11 12.3 0.1 0.17 11.7 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3328) ABC_tran PF00005.27 CCF35279.1 - 7.5e-49 165.8 0.1 1e-26 94.1 0.0 4.0 2 2 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 CCF35279.1 - 2.5e-13 50.5 6.7 8.9e-05 22.4 0.7 4.6 2 2 0 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CCF35279.1 - 1.3e-12 47.6 0.1 5.7e-05 22.7 0.0 4.0 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CCF35279.1 - 1.2e-09 39.0 1.8 7.2e-05 23.4 0.1 3.1 3 0 0 3 3 3 2 AAA domain Chromo PF00385.24 CCF35279.1 - 3.8e-09 36.3 0.7 7.8e-09 35.3 0.7 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain MMR_HSR1 PF01926.23 CCF35279.1 - 2.5e-07 30.8 0.0 0.0042 17.1 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_29 PF13555.6 CCF35279.1 - 4.6e-07 29.5 0.4 0.0075 16.0 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CCF35279.1 - 4.7e-07 29.9 0.1 0.004 17.1 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 CCF35279.1 - 4.4e-05 23.8 0.0 0.34 11.2 0.0 3.1 2 0 0 2 2 2 2 AAA domain AAA_28 PF13521.6 CCF35279.1 - 9.9e-05 22.6 0.0 0.023 14.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 CCF35279.1 - 0.00019 22.0 0.1 0.13 12.8 0.0 3.0 2 0 0 2 2 2 1 AAA domain DUF87 PF01935.17 CCF35279.1 - 0.0005 20.2 2.4 0.68 10.0 0.1 4.2 4 0 0 4 4 4 1 Helicase HerA, central domain NACHT PF05729.12 CCF35279.1 - 0.00076 19.4 0.2 0.53 10.2 0.0 2.9 3 0 0 3 3 2 1 NACHT domain RNA_helicase PF00910.22 CCF35279.1 - 0.00097 19.5 0.0 2.6 8.5 0.0 2.6 2 0 0 2 2 2 2 RNA helicase ALF PF03752.13 CCF35279.1 - 0.0017 18.2 3.0 0.62 10.1 0.1 3.7 4 0 0 4 4 3 1 Short repeats of unknown function MeaB PF03308.16 CCF35279.1 - 0.002 17.2 0.7 0.39 9.7 0.1 2.5 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_15 PF13175.6 CCF35279.1 - 0.0031 17.3 5.9 0.48 10.1 1.7 3.1 3 1 0 3 3 3 2 AAA ATPase domain AAA_33 PF13671.6 CCF35279.1 - 0.0045 17.2 1.1 4.3 7.5 0.0 3.2 3 0 0 3 3 2 1 AAA domain AAA_30 PF13604.6 CCF35279.1 - 0.007 16.1 0.5 2.2 7.9 0.1 2.9 2 0 0 2 2 2 1 AAA domain SbcCD_C PF13558.6 CCF35279.1 - 0.0077 16.4 0.1 5.7 7.3 0.0 3.4 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_24 PF13479.6 CCF35279.1 - 0.0096 15.7 0.5 0.85 9.3 0.2 2.7 2 0 0 2 2 2 1 AAA domain AAA_13 PF13166.6 CCF35279.1 - 0.011 14.4 0.7 1.2 7.7 0.0 2.8 3 0 0 3 3 2 0 AAA domain AAA PF00004.29 CCF35279.1 - 0.012 16.1 0.0 5.6 7.4 0.0 3.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.13 CCF35279.1 - 0.012 14.7 0.0 1.7 7.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_27 PF13514.6 CCF35279.1 - 0.015 14.9 0.6 7.1 6.2 0.0 3.0 3 0 0 3 3 3 0 AAA domain PduV-EutP PF10662.9 CCF35279.1 - 0.018 14.8 0.0 0.9 9.3 0.0 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Septin PF00735.18 CCF35279.1 - 0.024 13.9 0.0 6.1 6.0 0.0 2.5 2 0 0 2 2 2 0 Septin AAA_16 PF13191.6 CCF35279.1 - 0.035 14.5 0.2 5 7.5 0.0 3.3 4 0 0 4 4 2 0 AAA ATPase domain Dynamin_N PF00350.23 CCF35279.1 - 0.038 14.0 0.0 0.74 9.9 0.0 2.7 2 0 0 2 2 2 0 Dynamin family CLASP_N PF12348.8 CCF35279.1 - 0.041 13.4 0.0 0.13 11.8 0.0 1.8 1 0 0 1 1 1 0 CLASP N terminal SR-25 PF10500.9 CCF35279.1 - 0.044 13.4 3.6 0.084 12.5 3.6 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein NB-ARC PF00931.22 CCF35279.1 - 0.045 12.9 0.0 3.5 6.7 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain Roc PF08477.13 CCF35279.1 - 0.059 13.6 0.0 12 6.2 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase CLP1_P PF16575.5 CCF35279.1 - 0.064 13.1 0.7 26 4.5 0.0 3.7 4 0 0 4 4 4 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_14 PF13173.6 CCF35279.1 - 0.075 13.1 0.0 19 5.3 0.0 2.7 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 CCF35279.1 - 0.078 13.0 0.5 19 5.2 0.1 2.7 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE HEAT PF02985.22 CCF35279.1 - 0.16 12.3 1.1 1.3e+02 3.2 0.1 5.0 6 0 0 6 6 3 0 HEAT repeat NTPase_1 PF03266.15 CCF35279.1 - 0.19 11.6 0.6 25 4.7 0.5 2.8 2 0 0 2 2 2 0 NTPase cobW PF02492.19 CCF35279.1 - 0.42 10.2 1.7 28 4.2 0.1 2.9 3 0 0 3 3 2 0 CobW/HypB/UreG, nucleotide-binding domain DUF3584 PF12128.8 CCF35279.1 - 9 3.7 8.2 4.3 4.7 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3584) HSP70 PF00012.20 CCF35280.1 - 5.3e-11 41.4 0.3 1.5e-09 36.6 0.2 2.0 2 0 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 CCF35280.1 - 0.012 14.5 0.1 0.062 12.1 0.0 1.9 2 0 0 2 2 2 0 MreB/Mbl protein LepB_N PF18640.1 CCF35280.1 - 0.21 11.2 0.0 0.39 10.3 0.0 1.4 1 0 0 1 1 1 0 LepB N-terminal domain Thaumatin PF00314.17 CCF35281.1 - 2.3e-67 226.7 5.3 3.4e-67 226.2 5.3 1.2 1 0 0 1 1 1 1 Thaumatin family Glyco_hydro_64 PF16483.5 CCF35281.1 - 0.1 11.8 0.0 10 5.3 0.0 2.2 2 0 0 2 2 2 0 Beta-1,3-glucanase HIP1_clath_bdg PF16515.5 CCF35282.1 - 0.0094 16.5 3.9 0.0094 16.5 3.9 2.4 2 1 0 2 2 2 1 Clathrin-binding domain of Huntingtin-interacting protein 1 SUZ PF12752.7 CCF35283.1 - 0.016 15.9 0.2 0.15 12.8 0.0 2.1 2 0 0 2 2 2 0 SUZ domain RRM_1 PF00076.22 CCF35283.1 - 0.042 13.7 0.2 0.07 13.0 0.0 1.5 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Oxysterol_BP PF01237.18 CCF35284.1 - 7.9e-39 133.5 0.1 5.2e-38 130.9 0.1 1.8 1 1 0 1 1 1 1 Oxysterol-binding protein Peptidase_S10 PF00450.22 CCF35285.1 - 7.2e-72 243.1 0.0 2.9e-71 241.1 0.0 1.9 1 1 0 1 1 1 1 Serine carboxypeptidase Dynactin_p62 PF05502.13 CCF35286.1 - 0.023 13.5 0.8 0.026 13.3 0.8 1.0 1 0 0 1 1 1 0 Dynactin p62 family Pkinase PF00069.25 CCF35287.1 - 3.6e-12 46.2 0.0 7e-07 28.9 0.0 2.3 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCF35287.1 - 0.0028 17.0 0.0 0.0071 15.6 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Sharpin_PH PF16764.5 CCF35287.1 - 0.0052 16.5 0.0 0.011 15.5 0.0 1.4 1 0 0 1 1 1 1 Sharpin PH domain RTA1 PF04479.13 CCF35288.1 - 3e-72 242.6 8.2 3e-72 242.6 8.2 1.8 2 0 0 2 2 2 1 RTA1 like protein Abhydrolase_6 PF12697.7 CCF35289.1 - 1e-06 29.5 1.4 1e-06 29.5 1.4 2.2 1 1 1 2 2 2 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 CCF35289.1 - 3.1e-05 23.6 0.1 6.6e-05 22.5 0.1 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 CCF35289.1 - 0.0017 18.0 0.0 0.0039 16.9 0.0 1.6 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CCF35289.1 - 0.006 15.9 0.1 0.015 14.5 0.1 1.6 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Esterase PF00756.20 CCF35289.1 - 0.016 14.9 0.6 0.073 12.7 0.0 2.2 3 0 0 3 3 3 0 Putative esterase Abhydrolase_3 PF07859.13 CCF35289.1 - 0.019 14.8 0.0 0.036 13.9 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold AXE1 PF05448.12 CCF35289.1 - 0.11 11.2 0.0 0.24 10.0 0.0 1.5 2 0 0 2 2 2 0 Acetyl xylan esterase (AXE1) ADH_zinc_N PF00107.26 CCF35290.1 - 1.3e-07 31.6 0.0 2.8e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCF35290.1 - 6e-07 29.3 0.1 2.4e-06 27.4 0.0 1.9 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain FAD_binding_4 PF01565.23 CCF35291.1 - 2.2e-27 95.5 5.4 4.9e-27 94.4 5.4 1.6 2 0 0 2 2 2 1 FAD binding domain PMI_typeI PF01238.21 CCF35294.1 - 3.4e-139 464.2 0.0 4e-139 464.0 0.0 1.0 1 0 0 1 1 1 1 Phosphomannose isomerase type I Cupin_2 PF07883.11 CCF35294.1 - 0.072 12.8 0.0 1.6 8.5 0.0 2.4 2 0 0 2 2 2 0 Cupin domain RraB PF06877.11 CCF35294.1 - 0.12 13.2 0.1 0.41 11.4 0.0 1.9 2 0 0 2 2 2 0 Regulator of ribonuclease activity B AraC_binding PF02311.19 CCF35294.1 - 0.14 12.0 0.0 2.3 8.1 0.0 2.4 2 0 0 2 2 2 0 AraC-like ligand binding domain PapG_C PF03628.13 CCF35296.1 - 0.075 12.9 0.0 0.094 12.6 0.0 1.1 1 0 0 1 1 1 0 PapG chaperone-binding domain Aspzincin_M35 PF14521.6 CCF35297.1 - 0.00046 20.7 1.1 0.0035 17.9 1.1 2.2 1 1 0 1 1 1 1 Lysine-specific metallo-endopeptidase Zn_clus PF00172.18 CCF35298.1 - 4.7e-09 36.2 11.8 9e-09 35.3 11.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF3237 PF11578.8 CCF35300.1 - 7.7e-32 110.2 0.0 8.9e-32 110.0 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3237) Amidase PF01425.21 CCF35301.1 - 3e-83 280.3 0.0 2.4e-71 241.1 0.0 2.0 2 0 0 2 2 2 2 Amidase HTH_Tnp_Tc5 PF03221.16 CCF35302.1 - 2.7e-07 30.5 0.7 6e-07 29.4 0.0 1.9 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain zf-C2H2_4 PF13894.6 CCF35302.1 - 0.0032 18.2 22.3 0.0082 16.9 4.8 4.9 4 0 0 4 4 4 1 C2H2-type zinc finger zf_C2H2_ZHX PF18387.1 CCF35302.1 - 0.92 9.2 6.3 0.13 11.9 1.7 1.9 2 0 0 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-H2C2_2 PF13465.6 CCF35302.1 - 5.2 7.7 13.3 4.8 7.8 5.1 3.6 3 0 0 3 3 3 0 Zinc-finger double domain Herpes_capsid PF06112.11 CCF35302.1 - 6.3 6.8 16.1 0.17 12.0 9.1 2.0 2 0 0 2 2 2 0 Gammaherpesvirus capsid protein p450 PF00067.22 CCF35303.1 - 7.6e-52 176.6 0.0 9.4e-52 176.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 LisH PF08513.11 CCF35304.1 - 6e-07 29.2 0.1 1.5e-06 28.0 0.1 1.7 1 0 0 1 1 1 1 LisH WD40 PF00400.32 CCF35304.1 - 2.8e-06 27.9 9.5 0.087 13.7 0.0 6.4 7 0 0 7 7 7 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF35304.1 - 3.4e-06 27.3 0.2 0.16 12.3 0.1 4.7 2 2 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 CCF35304.1 - 0.11 12.4 0.0 20 5.3 0.0 3.3 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat Membr_traf_MHD PF10540.9 CCF35306.1 - 1.2e-18 67.7 1.2 1.6e-15 57.6 1.2 3.0 1 1 0 1 1 1 1 Munc13 (mammalian uncoordinated) homology domain C2 PF00168.30 CCF35306.1 - 5.5e-17 61.9 0.1 3.1e-16 59.5 0.0 2.2 2 0 0 2 2 2 1 C2 domain DUF810 PF05664.11 CCF35306.1 - 4.6e-05 22.2 0.2 7.9e-05 21.4 0.2 1.3 1 0 0 1 1 1 1 Plant family of unknown function (DUF810) Replic_Relax PF13814.6 CCF35306.1 - 0.055 13.5 0.3 0.17 12.0 0.3 1.8 1 0 0 1 1 1 0 Replication-relaxation Tub PF01167.18 CCF35306.1 - 0.12 12.1 1.3 4 7.1 0.0 2.4 2 0 0 2 2 2 0 Tub family RSN1_TM PF13967.6 CCF35308.1 - 6.3e-40 136.5 3.6 8.2e-40 136.1 3.6 1.1 1 0 0 1 1 1 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 CCF35308.1 - 5.6e-28 98.4 0.2 8e-28 97.8 0.2 1.2 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter TMF_TATA_bd PF12325.8 CCF35308.1 - 0.11 12.7 0.0 2.5 8.3 0.0 2.2 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Mito_carr PF00153.27 CCF35312.1 - 2.2e-16 59.6 5.4 4.8e-05 23.2 0.1 5.0 3 2 0 3 3 3 3 Mitochondrial carrier protein Fer2 PF00111.27 CCF35313.1 - 3.4e-13 49.3 1.1 4.9e-13 48.8 1.1 1.2 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Rrp15p PF07890.12 CCF35314.1 - 8.1e-40 136.3 13.7 8.1e-40 136.3 13.7 2.7 2 1 0 2 2 2 1 Rrp15p MR_MLE_N PF02746.16 CCF35314.1 - 0.047 13.9 0.2 0.13 12.5 0.2 1.7 1 0 0 1 1 1 0 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain SH3_1 PF00018.28 CCF35315.1 - 3.3e-05 23.4 0.0 7.8e-05 22.2 0.0 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 CCF35315.1 - 0.042 13.7 0.0 0.11 12.3 0.0 1.8 1 0 0 1 1 1 0 Variant SH3 domain Crystall_4 PF17945.1 CCF35315.1 - 0.086 13.3 0.1 0.36 11.3 0.0 2.0 2 0 0 2 2 2 0 Beta/Gamma crystallin Glyco_hydro_20 PF00728.22 CCF35317.1 - 1.7e-25 90.2 0.1 3.8e-19 69.3 0.0 2.6 1 1 1 2 2 2 2 Glycosyl hydrolase family 20, catalytic domain Glyco_hydro_20b PF02838.15 CCF35317.1 - 1.4e-07 32.3 0.0 2.9e-07 31.3 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 MF_alpha_N PF05436.11 CCF35318.1 - 0.038 13.9 0.6 0.047 13.6 0.6 1.2 1 0 0 1 1 1 0 Mating factor alpha precursor N-terminus tRNA_bind PF01588.20 CCF35320.1 - 2.7e-23 81.9 0.2 6.5e-23 80.7 0.2 1.7 1 0 0 1 1 1 1 Putative tRNA binding domain GST_C_2 PF13410.6 CCF35320.1 - 7.7e-06 25.8 0.0 1.4e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 CCF35320.1 - 0.0012 19.0 1.4 0.01 16.0 0.0 2.7 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 CCF35320.1 - 0.0074 16.5 0.0 0.02 15.1 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain HSP9_HSP12 PF04119.12 CCF35320.1 - 0.3 11.5 3.9 0.8 10.1 3.9 1.7 1 0 0 1 1 1 0 Heat shock protein 9/12 K_channel_TID PF07941.11 CCF35320.1 - 6.1 7.4 7.2 1.2 9.6 3.3 1.9 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain SNF2_N PF00176.23 CCF35321.1 - 2.6e-64 217.1 0.1 6.1e-64 215.9 0.1 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CCF35321.1 - 8.3e-23 80.8 0.0 3.4e-22 78.9 0.0 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCF35321.1 - 3.2e-07 30.5 2.0 4.8e-07 29.9 0.0 2.3 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 CCF35321.1 - 0.00015 21.1 0.0 0.00015 21.1 0.0 1.9 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase DEAD PF00270.29 CCF35321.1 - 0.00041 20.2 0.0 0.0018 18.1 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Tom22 PF04281.13 CCF35321.1 - 9.9 6.0 9.4 0.23 11.3 1.4 2.3 2 0 0 2 2 2 0 Mitochondrial import receptor subunit Tom22 hNIFK_binding PF12196.8 CCF35322.1 - 0.037 13.5 5.3 0.48 10.0 0.1 4.0 3 0 0 3 3 3 0 FHA Ki67 binding domain of hNIFK TMF_TATA_bd PF12325.8 CCF35322.1 - 0.047 13.9 5.4 0.22 11.7 1.1 2.7 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Macoilin PF09726.9 CCF35322.1 - 1.1 7.7 8.0 1.7 7.1 8.0 1.5 1 1 0 1 1 1 0 Macoilin family DUF3844 PF12955.7 CCF35323.1 - 4.4e-35 120.0 2.0 9.1e-35 119.0 2.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3844) AAA_12 PF13087.6 CCF35325.1 - 1.3e-57 194.7 0.0 1.5e-57 194.5 0.0 1.0 1 0 0 1 1 1 1 AAA domain UvrD_C PF13361.6 CCF35325.1 - 0.002 17.6 0.2 0.52 9.6 0.0 2.2 1 1 1 2 2 2 2 UvrD-like helicase C-terminal domain UvrD_C_2 PF13538.6 CCF35325.1 - 0.039 13.8 0.0 0.077 12.8 0.0 1.5 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain Amino_oxidase PF01593.24 CCF35326.1 - 3.5e-20 72.7 0.0 5.5e-20 72.1 0.0 1.3 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CCF35326.1 - 5.7e-14 52.1 0.0 1.4e-13 50.8 0.0 1.7 1 1 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CCF35326.1 - 3.7e-09 36.6 0.3 5.2e-08 32.8 0.3 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCF35326.1 - 2.4e-06 27.0 0.0 0.0002 20.7 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCF35326.1 - 7.9e-05 23.1 0.1 0.0016 18.9 0.1 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CCF35326.1 - 0.00056 19.9 0.0 0.0062 16.5 0.1 2.2 2 0 0 2 2 2 1 FAD-NAD(P)-binding Thi4 PF01946.17 CCF35326.1 - 0.0023 17.2 0.0 0.0037 16.5 0.0 1.2 1 0 0 1 1 1 1 Thi4 family Trp_halogenase PF04820.14 CCF35326.1 - 0.0045 15.9 0.1 0.0066 15.4 0.1 1.2 1 0 0 1 1 1 1 Tryptophan halogenase MCRA PF06100.11 CCF35326.1 - 0.011 14.6 0.0 0.029 13.2 0.0 1.6 2 0 0 2 2 2 0 MCRA family Mqo PF06039.15 CCF35326.1 - 0.048 12.2 0.0 0.078 11.5 0.0 1.2 1 0 0 1 1 1 0 Malate:quinone oxidoreductase (Mqo) zf-CCCH_2 PF14608.6 CCF35327.1 - 7.8e-14 51.6 60.4 2.9e-06 27.5 12.6 5.7 5 1 0 5 5 5 4 RNA-binding, Nab2-type zinc finger Nab2 PF11517.8 CCF35327.1 - 0.0092 16.3 0.0 0.018 15.3 0.0 1.4 1 0 0 1 1 1 1 Nuclear abundant poly(A) RNA-bind protein 2 (Nab2) Glyco_hydro_20 PF00728.22 CCF35328.1 - 7.1e-84 282.2 0.0 8.8e-84 281.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 CCF35328.1 - 1e-29 103.9 0.0 2.4e-29 102.8 0.0 1.7 2 0 0 2 2 2 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.15 CCF35328.1 - 1.9e-07 31.9 0.1 1.3e-05 26.0 0.0 2.3 2 0 0 2 2 2 1 Glycosyl hydrolase family 20, domain 2 p450 PF00067.22 CCF35329.1 - 1.9e-60 204.9 0.0 2.9e-60 204.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Aminotran_1_2 PF00155.21 CCF35330.1 - 1.1e-20 74.2 0.0 1.4e-20 73.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 CCF35330.1 - 6.1e-06 25.3 0.0 1.7e-05 23.8 0.0 1.6 1 1 0 1 1 1 1 Alanine-glyoxylate amino-transferase DegT_DnrJ_EryC1 PF01041.17 CCF35330.1 - 0.00073 18.9 0.0 0.022 14.1 0.0 2.1 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family adh_short PF00106.25 CCF35331.1 - 2e-16 60.0 0.0 6.9e-14 51.8 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCF35331.1 - 3e-12 46.6 0.0 3.6e-11 43.1 0.0 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.6 CCF35331.1 - 5.5e-05 23.1 0.0 8.7e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 CCF35331.1 - 8.8e-05 22.5 0.1 0.00022 21.2 0.1 1.6 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 CCF35331.1 - 0.0067 15.9 0.0 0.0083 15.6 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Glyco_transf_4 PF13439.6 CCF35331.1 - 0.02 14.9 0.1 0.04 13.9 0.1 1.6 1 0 0 1 1 1 0 Glycosyltransferase Family 4 YjeF_N PF03853.15 CCF35331.1 - 0.12 12.3 0.1 0.36 10.7 0.1 1.7 2 0 0 2 2 2 0 YjeF-related protein N-terminus NAD_binding_4 PF07993.12 CCF35331.1 - 0.15 11.2 0.0 4.6 6.3 0.0 2.1 2 0 0 2 2 2 0 Male sterility protein Inhibitor_I36 PF03995.13 CCF35332.1 - 0.015 15.2 0.6 0.023 14.6 0.6 1.2 1 0 0 1 1 1 0 Peptidase inhibitor family I36 MFS_1 PF07690.16 CCF35333.1 - 0.056 12.4 0.2 0.11 11.5 0.2 1.5 1 1 0 1 1 1 0 Major Facilitator Superfamily HECT PF00632.25 CCF35334.1 - 2.2e-95 319.7 0.1 6.6e-95 318.1 0.0 1.8 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) UBM PF14377.6 CCF35334.1 - 1.3e-08 34.0 1.7 3.4e-08 32.7 1.7 1.8 1 0 0 1 1 1 1 Ubiquitin binding region SIMPL PF04402.14 CCF35334.1 - 0.0038 17.7 4.4 0.0038 17.7 4.4 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF541) ALS2CR11 PF15729.5 CCF35334.1 - 0.019 14.1 1.2 0.036 13.2 1.2 1.4 1 0 0 1 1 1 0 Amyotrophic lateral sclerosis 2 candidate 11 BRCC36_C PF18110.1 CCF35334.1 - 0.021 15.0 0.8 2.9 8.1 0.1 3.0 2 0 0 2 2 2 0 BRCC36 C-terminal helical domain UCH PF00443.29 CCF35334.1 - 4.4 6.7 7.5 49 3.3 7.5 2.2 1 1 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase AIF-MLS PF14962.6 CCF35334.1 - 8.4 6.3 12.2 17 5.3 12.2 1.4 1 0 0 1 1 1 0 Mitochondria Localisation Sequence Pribosyl_synth PF14572.6 CCF35335.1 - 1.5e-42 145.7 0.5 6.8e-37 127.3 0.4 2.3 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.6 CCF35335.1 - 3.9e-25 88.1 0.2 1.9e-24 85.8 0.0 2.2 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.27 CCF35335.1 - 4.4e-16 58.8 1.1 6.4e-16 58.3 0.4 1.5 2 0 0 2 2 2 1 Phosphoribosyl transferase domain UPRTase PF14681.6 CCF35335.1 - 0.021 14.3 0.1 0.031 13.7 0.1 1.2 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase tRNA-synt_2 PF00152.20 CCF35336.1 - 1.4e-85 287.2 0.0 2e-85 286.6 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 CCF35336.1 - 8.6e-11 41.7 0.1 2.5e-10 40.2 0.0 1.8 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain tRNA_anti_2 PF13742.6 CCF35336.1 - 0.021 15.0 0.0 0.051 13.8 0.0 1.6 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain SPOUT_MTase PF02590.17 CCF35336.1 - 0.075 13.0 0.6 0.16 11.9 0.6 1.5 1 0 0 1 1 1 0 Predicted SPOUT methyltransferase PBP_sp32 PF07222.12 CCF35336.1 - 4.2 6.7 6.9 1.2 8.5 3.4 1.7 2 0 0 2 2 2 0 Proacrosin binding protein sp32 E1-E2_ATPase PF00122.20 CCF35338.1 - 8.1e-48 162.3 0.5 2.2e-47 160.9 0.5 1.8 1 0 0 1 1 1 1 E1-E2 ATPase HMA PF00403.26 CCF35338.1 - 6.8e-39 132.1 0.8 2.3e-13 50.4 0.1 4.8 4 0 0 4 4 4 4 Heavy-metal-associated domain Hydrolase PF00702.26 CCF35338.1 - 7.9e-35 121.1 1.6 2.8e-34 119.2 1.0 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 CCF35338.1 - 1.8e-07 31.8 0.0 3.7e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 CCF35338.1 - 4.8e-07 29.8 0.1 1.8e-05 24.6 0.1 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase 7TM_GPCR_Srh PF10318.9 CCF35338.1 - 0.035 13.2 2.3 0.043 12.8 0.1 2.1 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srh DUF5105 PF17118.5 CCF35338.1 - 0.067 13.0 1.4 20 4.9 0.0 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF5105) Pox_E10 PF04805.12 CCF35338.1 - 0.31 10.9 3.9 2.2 8.2 0.1 3.6 4 0 0 4 4 4 0 E10-like protein conserved region RPN6_C_helix PF18503.1 CCF35338.1 - 0.72 9.6 2.5 5.3 6.9 0.2 2.6 2 0 0 2 2 2 0 26S proteasome subunit RPN6 C-terminal helix domain DUF3795 PF12675.7 CCF35338.1 - 1.3 9.5 4.7 50 4.4 0.7 4.1 4 1 0 4 4 4 0 Protein of unknown function (DUF3795) PFOR_II PF17147.4 CCF35339.1 - 1.1e-07 32.1 0.1 2.5e-07 30.9 0.1 1.6 1 0 0 1 1 1 1 Pyruvate:ferredoxin oxidoreductase core domain II Transketolase_C PF02780.20 CCF35339.1 - 0.0033 17.3 0.1 0.011 15.7 0.1 1.8 1 0 0 1 1 1 1 Transketolase, C-terminal domain DUF5610 PF18433.1 CCF35339.1 - 0.1 13.1 0.0 0.23 12.0 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF5610) Abhydrolase_1 PF00561.20 CCF35342.1 - 2.8e-17 63.2 0.1 3.7e-17 62.8 0.1 1.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCF35342.1 - 2.9e-13 50.9 2.5 3.5e-13 50.7 2.5 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCF35342.1 - 1.7e-09 37.3 0.2 2.4e-09 36.8 0.2 1.5 1 1 0 1 1 1 1 Serine aminopeptidase, S33 AXE1 PF05448.12 CCF35342.1 - 0.092 11.4 0.0 0.13 10.9 0.0 1.2 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Pro_racemase PF05544.11 CCF35343.1 - 4.6e-57 193.5 0.0 6e-57 193.1 0.0 1.1 1 0 0 1 1 1 1 Proline racemase Calmodulin_bind PF07887.11 CCF35344.1 - 0.023 14.0 0.0 0.036 13.4 0.0 1.2 1 0 0 1 1 1 0 Calmodulin binding protein-like Abhydrolase_1 PF00561.20 CCF35346.1 - 7.7e-46 156.8 0.0 1.9e-45 155.5 0.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCF35346.1 - 0.012 16.2 5.5 0.023 15.3 5.5 1.6 1 1 0 1 1 1 0 Alpha/beta hydrolase family Say1_Mug180 PF10340.9 CCF35346.1 - 0.21 10.4 0.0 0.31 9.9 0.0 1.2 1 0 0 1 1 1 0 Steryl acetyl hydrolase Sugar_tr PF00083.24 CCF35347.1 - 8e-45 153.5 5.2 9e-45 153.4 5.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_2 PF13347.6 CCF35347.1 - 1.4e-05 23.8 3.2 1.4e-05 23.8 3.2 1.4 2 0 0 2 2 2 1 MFS/sugar transport protein EphA2_TM PF14575.6 CCF35348.1 - 6.2e-05 23.8 0.1 0.00024 21.9 0.1 1.9 1 1 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain TMEM154 PF15102.6 CCF35348.1 - 0.00055 19.9 0.0 0.0012 18.8 0.0 1.5 2 0 0 2 2 2 1 TMEM154 protein family Prominin PF05478.11 CCF35348.1 - 0.0008 17.5 6.6 0.00082 17.5 3.7 1.9 2 0 0 2 2 2 1 Prominin ETRAMP PF09716.10 CCF35348.1 - 0.0011 18.9 5.2 0.0024 17.9 5.2 1.5 1 1 0 1 1 1 1 Malarial early transcribed membrane protein (ETRAMP) Shisa PF13908.6 CCF35348.1 - 0.0012 19.1 0.3 0.0031 17.8 0.0 1.7 2 0 0 2 2 2 1 Wnt and FGF inhibitory regulator SR-25 PF10500.9 CCF35348.1 - 0.0016 18.1 6.2 0.0022 17.7 6.2 1.1 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein SARAF PF06682.12 CCF35348.1 - 0.0028 17.4 0.0 0.0031 17.2 0.0 1.1 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis DUF4448 PF14610.6 CCF35348.1 - 0.011 15.6 0.0 0.042 13.6 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4448) TMEM52 PF14979.6 CCF35348.1 - 0.051 13.5 0.6 0.09 12.7 0.6 1.3 1 0 0 1 1 1 0 Transmembrane 52 Herpes_gE PF02480.16 CCF35348.1 - 0.063 12.0 0.0 0.084 11.6 0.0 1.1 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E GRP PF07172.11 CCF35348.1 - 0.1 13.3 9.8 0.1 13.3 4.4 2.4 3 0 0 3 3 2 0 Glycine rich protein family Tweety PF04906.13 CCF35348.1 - 0.2 10.2 3.3 0.52 8.9 1.6 1.9 2 0 0 2 2 2 0 Tweety RCR PF12273.8 CCF35348.1 - 1.5 9.5 11.6 28 5.4 11.6 2.5 1 1 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red zf-ZPR1 PF03367.13 CCF35349.1 - 0.07 13.0 0.0 0.1 12.5 0.0 1.2 1 0 0 1 1 1 0 ZPR1 zinc-finger domain p450 PF00067.22 CCF35350.1 - 1.2e-25 90.2 0.0 3.1e-22 79.0 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 PLN_propep PF16485.5 CCF35351.1 - 0.12 12.1 0.4 0.44 10.3 0.0 2.0 2 0 0 2 2 2 0 Protealysin propeptide HET PF06985.11 CCF35352.1 - 9.2e-32 110.4 0.1 2.7e-31 108.9 0.1 1.8 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) AAL_decarboxy PF03306.13 CCF35352.1 - 0.085 12.2 0.0 0.15 11.3 0.0 1.4 1 0 0 1 1 1 0 Alpha-acetolactate decarboxylase Cpn60_TCP1 PF00118.24 CCF35353.1 - 2.8e-153 511.1 6.4 3.2e-153 510.9 6.4 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family GNAT_acetyltran PF12746.7 CCF35353.1 - 0.044 13.4 0.1 0.12 12.0 0.1 1.7 1 0 0 1 1 1 0 GNAT acetyltransferase zf-C2H2 PF00096.26 CCF35354.1 - 3.4e-11 42.9 17.0 0.00011 22.4 5.4 3.7 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CCF35354.1 - 5e-08 33.0 11.2 0.0021 18.4 2.2 3.7 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 CCF35354.1 - 9.5e-06 26.0 15.9 0.057 14.3 4.5 3.7 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_11 PF16622.5 CCF35354.1 - 0.016 14.9 1.3 0.016 14.9 1.3 2.6 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-C2H2_6 PF13912.6 CCF35354.1 - 0.15 12.1 6.5 5.7 7.1 0.1 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger AT_hook PF02178.19 CCF35354.1 - 0.95 9.5 4.0 2.7 8.2 4.0 1.8 1 0 0 1 1 1 0 AT hook motif C1_4 PF07975.12 CCF35354.1 - 3 8.1 7.6 6.6 7.1 7.6 1.6 1 0 0 1 1 1 0 TFIIH C1-like domain MFS_1 PF07690.16 CCF35355.1 - 1.7e-20 73.2 38.7 1.7e-20 73.2 38.7 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_1_like PF12832.7 CCF35355.1 - 0.00022 20.2 20.2 0.0057 15.6 7.0 3.0 1 1 2 3 3 3 3 MFS_1 like family OATP PF03137.20 CCF35355.1 - 0.054 11.8 0.0 0.054 11.8 0.0 2.9 1 1 2 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family GMC_oxred_N PF00732.19 CCF35356.1 - 1.7e-55 188.5 0.0 2.3e-55 188.1 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCF35356.1 - 2e-34 119.2 0.0 3e-34 118.6 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 CCF35356.1 - 4.1e-08 32.7 0.3 0.0078 15.3 0.0 2.4 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 CCF35356.1 - 7.6e-05 22.4 2.6 0.0028 17.3 2.6 2.3 1 1 0 1 1 1 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 CCF35356.1 - 8.7e-05 21.7 0.2 0.00014 21.0 0.2 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein Thi4 PF01946.17 CCF35356.1 - 0.00041 19.7 0.1 0.00064 19.0 0.1 1.3 1 0 0 1 1 1 1 Thi4 family NAD_binding_8 PF13450.6 CCF35356.1 - 0.0062 16.7 0.1 0.014 15.6 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CCF35356.1 - 0.014 14.6 0.0 0.025 13.8 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCF35356.1 - 0.05 12.9 0.7 2.5 7.3 0.5 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CCF35356.1 - 0.28 10.2 0.3 0.74 8.8 0.1 1.7 2 0 0 2 2 2 0 Glucose inhibited division protein A HTH_psq PF05225.16 CCF35357.1 - 1e-11 44.3 0.1 1.9e-11 43.5 0.1 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.16 CCF35357.1 - 2.6e-11 43.4 0.6 1e-10 41.5 0.0 2.1 3 0 0 3 3 3 1 Tc5 transposase DNA-binding domain HTH_23 PF13384.6 CCF35357.1 - 0.00015 21.5 0.1 0.00045 19.9 0.1 1.8 1 1 0 1 1 1 1 Homeodomain-like domain HTH_7 PF02796.15 CCF35357.1 - 0.00086 19.3 0.1 0.0016 18.5 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_30 PF13556.6 CCF35357.1 - 0.0023 17.7 0.1 0.0058 16.4 0.1 1.6 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain HTH_28 PF13518.6 CCF35357.1 - 0.0058 16.7 0.5 0.016 15.4 0.1 2.0 2 1 1 3 3 3 1 Helix-turn-helix domain HTH_Tnp_1 PF01527.20 CCF35357.1 - 0.015 15.6 0.4 0.039 14.3 0.4 1.8 1 1 1 2 2 2 0 Transposase HTH_1 PF00126.27 CCF35357.1 - 0.026 14.5 0.3 0.056 13.4 0.2 1.6 1 1 0 1 1 1 0 Bacterial regulatory helix-turn-helix protein, lysR family CENP-B_N PF04218.13 CCF35357.1 - 0.076 12.7 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain Fungal_trans_2 PF11951.8 CCF35358.1 - 3e-07 29.6 0.0 4.6e-07 29.0 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF35358.1 - 1.5e-06 28.2 9.3 2.5e-06 27.5 9.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-3CxxC PF13695.6 CCF35360.1 - 1.2e-21 77.1 0.1 1.8e-21 76.5 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding domain Fungal_trans PF04082.18 CCF35361.1 - 5.3e-11 42.1 0.0 1.8e-10 40.3 0.0 1.9 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF35361.1 - 0.0011 19.0 6.3 0.0018 18.4 6.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain dCMP_cyt_deam_1 PF00383.23 CCF35363.1 - 2.1e-08 34.0 0.0 3.1e-08 33.4 0.0 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 CCF35363.1 - 6.3e-06 26.0 0.0 1.4e-05 24.9 0.0 1.4 1 1 0 1 1 1 1 MafB19-like deaminase Methyltransf_16 PF10294.9 CCF35364.1 - 1e-24 87.2 0.0 7.5e-24 84.4 0.0 2.0 1 1 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 CCF35364.1 - 0.00016 21.6 0.0 0.00028 20.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF35364.1 - 0.01 16.6 0.0 0.018 15.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain V_ATPase_I PF01496.19 CCF35366.1 - 0.012 13.6 0.0 0.016 13.2 0.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TMEM132D_C PF15706.5 CCF35366.1 - 0.03 14.1 0.2 0.46 10.3 0.0 2.2 2 0 0 2 2 2 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term DUF5102 PF17104.5 CCF35368.1 - 0.0097 16.0 0.7 0.0097 16.0 0.7 4.3 3 1 2 5 5 5 1 Domain of unknown function (DUF5102) RRM_1 PF00076.22 CCF35369.1 - 1.2e-19 69.9 0.0 1.5e-19 69.6 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CCF35369.1 - 0.00076 19.6 0.0 0.0011 19.0 0.0 1.4 1 1 0 1 1 1 1 RNA recognition motif PAP_PilO PF06864.12 CCF35369.1 - 0.021 13.7 0.0 0.022 13.6 0.0 1.0 1 0 0 1 1 1 0 Pilin accessory protein (PilO) RRM_1 PF00076.22 CCF35370.1 - 7.1e-37 125.1 0.1 2.8e-11 43.1 0.1 4.6 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CCF35370.1 - 4.8e-15 55.2 0.0 0.0085 15.9 0.0 4.3 4 0 0 4 4 4 4 Occluded RNA-recognition motif RRM PF10378.9 CCF35370.1 - 3.2e-07 29.9 12.2 3.2e-07 29.9 12.2 3.8 3 1 1 4 4 4 1 Putative RRM domain DUF4523 PF15023.6 CCF35370.1 - 2.2e-06 27.6 0.0 0.034 14.0 0.0 3.3 3 0 0 3 3 3 2 Protein of unknown function (DUF4523) RRM_7 PF16367.5 CCF35370.1 - 2.2e-05 24.5 0.0 0.21 11.7 0.0 4.0 4 0 0 4 4 4 2 RNA recognition motif RRM_3 PF08777.11 CCF35370.1 - 0.086 12.9 5.7 0.14 12.2 0.2 3.1 4 0 0 4 4 4 0 RNA binding motif RNA_bind PF08675.11 CCF35370.1 - 0.11 12.6 0.8 0.36 10.9 0.0 2.3 3 0 0 3 3 3 0 RNA binding domain Nup35_RRM_2 PF14605.6 CCF35370.1 - 0.15 12.1 0.0 59 3.8 0.0 3.3 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif Neurochondrin PF05536.11 CCF35371.1 - 4.3e-24 84.8 0.0 5.1e-24 84.6 0.0 1.0 1 0 0 1 1 1 1 Neurochondrin Pro-kuma_activ PF09286.11 CCF35372.1 - 0.056 13.7 0.5 0.22 11.8 0.1 2.1 2 1 1 3 3 3 0 Pro-kumamolisin, activation domain AAA PF00004.29 CCF35373.1 - 2.9e-18 66.6 0.1 3.9e-16 59.7 0.0 2.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CCF35373.1 - 0.00039 20.9 0.0 0.0015 19.0 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 CCF35373.1 - 0.0013 19.0 0.4 0.012 15.9 0.0 2.5 1 1 1 2 2 2 1 AAA domain AAA_11 PF13086.6 CCF35373.1 - 0.0084 15.9 2.5 1.3 8.7 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 CCF35373.1 - 0.018 15.0 0.0 0.049 13.6 0.0 1.9 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 CCF35373.1 - 0.039 13.7 0.0 0.11 12.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain Torsin PF06309.11 CCF35373.1 - 0.044 13.9 0.0 0.15 12.2 0.0 1.9 1 0 0 1 1 1 0 Torsin Zot PF05707.12 CCF35373.1 - 0.054 13.1 0.1 1 8.9 0.0 2.3 2 0 0 2 2 2 0 Zonular occludens toxin (Zot) Vps36_ESCRT-II PF11605.8 CCF35373.1 - 0.096 12.9 0.0 0.26 11.5 0.0 1.7 1 0 0 1 1 1 0 Vacuolar protein sorting protein 36 Vps36 Phage_int_SAM_5 PF13102.6 CCF35373.1 - 0.1 12.9 0.6 17 5.8 0.0 2.8 1 1 1 2 2 2 0 Phage integrase SAM-like domain AAA_33 PF13671.6 CCF35373.1 - 0.17 12.1 0.7 0.44 10.7 0.1 2.1 2 0 0 2 2 2 0 AAA domain DUF918 PF06033.11 CCF35374.1 - 0.046 13.7 0.0 0.071 13.1 0.0 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF918) DDE_1 PF03184.19 CCF35374.1 - 0.054 13.1 0.0 0.1 12.2 0.0 1.5 1 0 0 1 1 1 0 DDE superfamily endonuclease MFS_1 PF07690.16 CCF35376.1 - 2.6e-25 89.1 25.8 3.7e-25 88.6 25.5 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF35376.1 - 5e-17 61.9 18.0 7.5e-17 61.3 18.0 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter OapA_N PF08525.11 CCF35376.1 - 1.8 8.6 6.4 12 6.0 0.2 2.8 3 0 0 3 3 3 0 Opacity-associated protein A N-terminal motif Uso1_p115_head PF04869.14 CCF35377.1 - 1.2e-118 395.8 0.1 3.8e-118 394.2 0.0 1.9 2 0 0 2 2 2 1 Uso1 / p115 like vesicle tethering protein, head region Uso1_p115_C PF04871.13 CCF35377.1 - 3.1e-19 69.6 33.3 3.1e-19 69.6 33.3 4.4 1 1 4 5 5 5 1 Uso1 / p115 like vesicle tethering protein, C terminal region DUF5591 PF17884.1 CCF35377.1 - 3.3 7.6 6.4 33 4.3 0.0 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF5591) Methyltransf_25 PF13649.6 CCF35378.1 - 1.8e-13 51.0 0.0 4.8e-13 49.6 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF35378.1 - 1.5e-11 44.8 0.0 3.9e-11 43.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 CCF35378.1 - 1.7e-10 40.8 1.1 2.2e-10 40.4 0.0 1.7 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 CCF35378.1 - 4.6e-08 33.0 0.0 1.1e-07 31.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF35378.1 - 7e-06 26.0 0.0 1.8e-05 24.6 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF35378.1 - 1.1e-05 26.1 0.0 3.3e-05 24.5 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 CCF35378.1 - 1.5e-05 25.0 0.0 2.6e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CCF35378.1 - 1.6e-05 24.5 0.1 3e-05 23.6 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_16 PF10294.9 CCF35378.1 - 0.00038 20.2 0.0 0.0044 16.8 0.0 2.6 3 0 0 3 3 3 1 Lysine methyltransferase RasGAP_C PF03836.15 CCF35378.1 - 0.001 19.2 0.7 0.002 18.3 0.7 1.5 1 0 0 1 1 1 1 RasGAP C-terminus Methyltransf_9 PF08003.11 CCF35378.1 - 0.0038 16.2 0.1 0.0064 15.5 0.1 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1698) CMAS PF02353.20 CCF35378.1 - 0.022 14.1 0.0 0.049 12.9 0.0 1.5 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Mito_fiss_reg PF05308.11 CCF35378.1 - 0.039 14.1 0.1 0.06 13.4 0.1 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator TehB PF03848.14 CCF35378.1 - 0.044 13.2 0.0 0.075 12.4 0.0 1.4 1 0 0 1 1 1 0 Tellurite resistance protein TehB PCMT PF01135.19 CCF35378.1 - 0.1 12.3 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) OPT PF03169.15 CCF35379.1 - 2.3e-150 502.2 26.6 2.7e-150 502.0 26.6 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Phage_holin_2_3 PF16080.5 CCF35379.1 - 0.11 12.2 5.5 0.3 10.9 0.6 3.4 2 0 0 2 2 2 0 Bacteriophage holin family HP1 Phage_holin_2_1 PF04971.12 CCF35379.1 - 1.3 9.0 5.5 0.49 10.4 0.4 2.9 2 0 0 2 2 2 0 Bacteriophage P21 holin S Rav1p_C PF12234.8 CCF35380.1 - 8.6e-281 933.0 0.0 1.1e-280 932.6 0.0 1.1 1 0 0 1 1 1 1 RAVE protein 1 C terminal HTH_Tnp_Tc5 PF03221.16 CCF35382.1 - 1.2e-09 38.1 0.1 3.8e-09 36.4 0.1 1.9 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.13 CCF35382.1 - 0.00032 20.3 0.0 0.00056 19.5 0.0 1.4 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain MarR PF01047.22 CCF35382.1 - 0.011 15.7 0.0 0.03 14.2 0.0 1.8 1 0 0 1 1 1 0 MarR family HTH_Crp_2 PF13545.6 CCF35382.1 - 0.011 15.7 0.0 0.036 14.1 0.0 1.8 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain HTH_Tnp_4 PF13613.6 CCF35382.1 - 0.013 15.2 0.0 0.023 14.4 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix of DDE superfamily endonuclease PTR2 PF00854.21 CCF35383.1 - 8.3e-79 265.2 9.4 1.2e-78 264.7 9.4 1.1 1 0 0 1 1 1 1 POT family MFS_1 PF07690.16 CCF35383.1 - 0.00072 18.6 31.5 0.00072 18.6 31.5 2.7 1 1 1 2 2 2 1 Major Facilitator Superfamily Phage_holin_3_6 PF07332.11 CCF35383.1 - 3.5 7.7 16.9 4.1 7.5 2.7 3.9 4 0 0 4 4 4 0 Putative Actinobacterial Holin-X, holin superfamily III HAT_KAT11 PF08214.11 CCF35384.1 - 3.4e-96 322.6 0.0 5.4e-96 321.9 0.0 1.3 1 0 0 1 1 1 1 Histone acetylation protein GDI PF00996.18 CCF35386.1 - 4.1e-196 651.7 0.0 4.6e-196 651.5 0.0 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor NAD_binding_8 PF13450.6 CCF35386.1 - 0.028 14.6 0.0 0.067 13.4 0.0 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 CCF35386.1 - 0.081 13.5 0.3 0.66 10.6 0.1 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NOG1_N PF17835.1 CCF35387.1 - 5.1e-50 169.6 0.0 1.3e-49 168.2 0.0 1.7 1 0 0 1 1 1 1 NOG1 N-terminal helical domain NOGCT PF08155.11 CCF35387.1 - 1.7e-27 95.1 0.9 4e-27 93.9 0.9 1.7 1 0 0 1 1 1 1 NOGCT (NUC087) domain NOG1 PF06858.14 CCF35387.1 - 3.5e-26 90.8 0.8 8.1e-26 89.6 0.8 1.7 1 0 0 1 1 1 1 Nucleolar GTP-binding protein 1 (NOG1) MMR_HSR1 PF01926.23 CCF35387.1 - 8.1e-15 54.9 0.0 1.8e-14 53.8 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CCF35387.1 - 2.6e-08 33.5 0.0 4.9e-08 32.6 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B Gtr1_RagA PF04670.12 CCF35387.1 - 0.0023 17.3 0.1 0.0039 16.6 0.1 1.4 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 CCF35387.1 - 0.014 15.3 3.8 0.11 12.4 0.1 3.3 3 1 0 3 3 3 0 RsgA GTPase AAA_16 PF13191.6 CCF35387.1 - 0.027 14.9 0.0 0.17 12.2 0.0 2.5 1 1 0 1 1 1 0 AAA ATPase domain MMR_HSR1_Xtn PF16897.5 CCF35387.1 - 0.028 14.5 0.0 0.068 13.2 0.0 1.6 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain APH PF01636.23 CCF35387.1 - 0.074 13.0 0.0 0.18 11.7 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF3585 PF12130.8 CCF35387.1 - 0.68 10.1 11.7 0.23 11.6 7.1 2.2 2 0 0 2 2 2 0 Bivalent Mical/EHBP Rab binding domain Dynamin_N PF00350.23 CCF35387.1 - 1.4 8.9 7.2 1.5 8.8 0.0 2.9 4 0 0 4 4 4 0 Dynamin family DUF1690 PF07956.11 CCF35387.1 - 3.2 8.2 10.6 1.5 9.2 3.6 2.9 3 0 0 3 3 3 0 Protein of Unknown function (DUF1690) Aconitase PF00330.20 CCF35388.1 - 1.8e-107 360.2 0.1 1.5e-106 357.2 0.1 2.0 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 CCF35388.1 - 1.4e-25 90.2 0.0 2.6e-25 89.2 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain ETF PF01012.21 CCF35388.1 - 0.06 13.2 0.2 0.13 12.1 0.2 1.5 1 0 0 1 1 1 0 Electron transfer flavoprotein domain adh_short PF00106.25 CCF35391.1 - 2.3e-09 37.0 0.0 2.1e-08 33.9 0.0 2.0 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF35391.1 - 6.7e-06 25.8 0.0 1.7e-05 24.5 0.0 1.6 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF35391.1 - 0.0056 16.6 0.0 0.0097 15.8 0.0 1.3 1 0 0 1 1 1 1 KR domain NmrA PF05368.13 CCF35392.1 - 1.6e-36 126.0 0.0 2.5e-36 125.4 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CCF35392.1 - 3.7e-15 56.3 0.0 4.4e-15 56.0 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CCF35392.1 - 4.6e-07 29.5 0.0 6.9e-07 29.0 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 CCF35392.1 - 1.9e-05 24.7 0.4 3e-05 24.0 0.4 1.3 1 0 0 1 1 1 1 KR domain 3Beta_HSD PF01073.19 CCF35392.1 - 0.0041 16.2 0.0 0.0059 15.6 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short PF00106.25 CCF35392.1 - 0.029 13.8 0.2 0.063 12.7 0.2 1.6 1 1 0 1 1 1 0 short chain dehydrogenase GDP_Man_Dehyd PF16363.5 CCF35392.1 - 0.082 12.3 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase DapB_N PF01113.20 CCF35392.1 - 0.099 12.8 0.0 0.2 11.8 0.0 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Crystall_2 PF09076.10 CCF35393.1 - 0.17 11.8 0.0 0.19 11.6 0.0 1.1 1 0 0 1 1 1 0 Beta/Gamma crystallin CDP-OH_P_transf PF01066.21 CCF35394.1 - 4.5e-13 49.7 0.5 4.5e-13 49.7 0.5 2.2 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase MFS_1 PF07690.16 CCF35395.1 - 2.4e-28 99.1 26.6 2.4e-28 99.1 26.6 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Phage_holin_5_1 PF06946.11 CCF35395.1 - 0.51 10.7 3.4 24 5.4 0.1 2.5 2 0 0 2 2 2 0 Bacteriophage A118-like holin, Hol118 Sin_N PF04801.13 CCF35397.1 - 1.3e-07 31.3 0.0 2.3e-07 30.4 0.0 1.4 1 1 0 1 1 1 1 Sin-like protein conserved region Snf7 PF03357.21 CCF35398.1 - 3.6e-30 104.8 17.1 4e-30 104.7 17.1 1.0 1 0 0 1 1 1 1 Snf7 CCDC24 PF15669.5 CCF35398.1 - 0.039 13.8 8.3 0.057 13.3 8.3 1.3 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 24 family DUF3138 PF11336.8 CCF35398.1 - 0.095 11.3 7.0 0.032 12.9 3.7 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3138) Allexi_40kDa PF05549.11 CCF35398.1 - 1.1 8.7 6.5 1.7 8.1 6.5 1.4 1 1 0 1 1 1 0 Allexivirus 40kDa protein TraB PF01963.17 CCF35398.1 - 4 7.2 10.2 6.9 6.5 10.2 1.4 1 1 0 1 1 1 0 TraB family Ten1 PF12658.7 CCF35399.1 - 4.7e-30 104.0 0.0 5.5e-30 103.8 0.0 1.1 1 0 0 1 1 1 1 Telomere capping, CST complex subunit Ten1_2 PF15490.6 CCF35399.1 - 0.00028 20.6 0.0 0.00034 20.3 0.0 1.1 1 0 0 1 1 1 1 Telomere-capping, CST complex subunit Rep_fac-A_3 PF08661.11 CCF35399.1 - 0.06 13.7 0.0 0.098 13.0 0.0 1.4 1 1 0 1 1 1 0 Replication factor A protein 3 STPPase_N PF16891.5 CCF35400.1 - 0.11 12.9 0.0 0.2 12.1 0.0 1.4 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain Acetate_kinase PF00871.17 CCF35402.1 - 1.6e-94 316.8 0.0 1.9e-94 316.6 0.0 1.0 1 0 0 1 1 1 1 Acetokinase family Inositol_P PF00459.25 CCF35403.1 - 1.5e-49 168.9 0.9 3.4e-49 167.8 0.9 1.5 1 1 0 1 1 1 1 Inositol monophosphatase family DUF2630 PF10944.8 CCF35403.1 - 0.0018 18.7 0.1 0.0035 17.8 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2630) Ribosomal_L6 PF00347.23 CCF35404.1 - 2.6e-18 66.4 0.0 1.8e-08 34.9 0.0 2.8 2 1 1 3 3 3 2 Ribosomal protein L6 Tubulin PF00091.25 CCF35405.1 - 1.7e-68 230.8 0.0 4.3e-68 229.4 0.0 1.6 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 CCF35405.1 - 8.9e-43 145.5 0.1 1.4e-42 144.8 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 CCF35405.1 - 1.5e-05 25.2 0.0 5.4e-05 23.5 0.0 1.9 2 0 0 2 2 2 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 CCF35405.1 - 0.0039 16.9 0.0 0.0071 16.0 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.6 CCF35405.1 - 0.0046 16.2 0.0 0.024 13.8 0.0 1.9 2 0 0 2 2 2 1 Tubulin like ABC_tran PF00005.27 CCF35406.1 - 2.8e-49 167.2 0.5 4.5e-23 82.3 0.0 3.3 3 0 0 3 3 3 2 ABC transporter ABC_tran_Xtn PF12848.7 CCF35406.1 - 1e-20 73.5 6.9 1e-20 73.5 6.9 4.1 5 0 0 5 5 4 1 ABC transporter AAA_21 PF13304.6 CCF35406.1 - 3.8e-17 63.1 0.6 0.001 19.0 0.0 4.5 3 1 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CCF35406.1 - 6.7e-10 38.8 5.1 0.0018 17.7 0.0 4.5 5 0 0 5 5 4 3 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 CCF35406.1 - 1.3e-06 28.4 0.1 0.015 15.4 0.0 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_18 PF13238.6 CCF35406.1 - 1.4e-06 28.9 0.1 0.068 13.7 0.0 3.4 3 0 0 3 3 3 2 AAA domain AAA_30 PF13604.6 CCF35406.1 - 2.3e-06 27.4 0.2 0.0066 16.2 0.0 3.6 3 1 0 3 3 3 1 AAA domain AAA_29 PF13555.6 CCF35406.1 - 5e-06 26.1 0.2 0.055 13.2 0.0 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 CCF35406.1 - 1.2e-05 25.7 1.8 0.022 15.1 0.2 2.9 3 0 0 3 3 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 CCF35406.1 - 2e-05 24.6 2.2 0.077 12.9 0.1 3.3 2 1 1 3 3 3 2 RsgA GTPase AAA_33 PF13671.6 CCF35406.1 - 2.7e-05 24.4 0.1 0.35 11.0 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_15 PF13175.6 CCF35406.1 - 2.7e-05 24.0 8.2 0.3 10.7 0.0 4.8 5 0 0 5 5 5 2 AAA ATPase domain AAA_24 PF13479.6 CCF35406.1 - 4.7e-05 23.2 1.0 0.74 9.5 0.0 3.4 3 0 0 3 3 3 2 AAA domain AAA_23 PF13476.6 CCF35406.1 - 5.2e-05 23.8 17.8 0.028 14.9 0.0 4.8 5 0 0 5 5 5 2 AAA domain AAA_28 PF13521.6 CCF35406.1 - 6e-05 23.3 1.1 0.042 14.1 0.0 2.9 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 CCF35406.1 - 7.8e-05 23.0 0.1 0.44 10.8 0.1 3.1 3 1 0 3 3 2 2 AAA domain AAA PF00004.29 CCF35406.1 - 0.00075 19.9 0.0 0.53 10.7 0.0 3.0 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 CCF35406.1 - 0.001 19.1 0.2 3.3 7.7 0.0 3.3 3 0 0 3 3 3 2 AAA domain Dynamin_N PF00350.23 CCF35406.1 - 0.0028 17.8 6.4 1.1 9.3 0.0 4.2 4 1 0 4 4 4 1 Dynamin family MeaB PF03308.16 CCF35406.1 - 0.003 16.6 0.1 1.9 7.4 0.0 2.8 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB RNA_helicase PF00910.22 CCF35406.1 - 0.0049 17.2 0.0 3.1 8.2 0.0 2.7 2 0 0 2 2 2 1 RNA helicase NACHT PF05729.12 CCF35406.1 - 0.0064 16.4 0.1 4.3 7.2 0.0 2.7 2 0 0 2 2 2 1 NACHT domain cobW PF02492.19 CCF35406.1 - 0.0069 16.0 0.5 1.6 8.3 0.6 2.5 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_7 PF12775.7 CCF35406.1 - 0.01 15.4 0.0 5.7 6.4 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region NTPase_1 PF03266.15 CCF35406.1 - 0.013 15.5 0.0 1.4 8.8 0.0 2.7 2 0 0 2 2 2 0 NTPase AAA_5 PF07728.14 CCF35406.1 - 0.019 15.0 0.2 6.7 6.7 0.0 3.1 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) Roc PF08477.13 CCF35406.1 - 0.025 14.8 0.1 5.6 7.2 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase MobB PF03205.14 CCF35406.1 - 0.041 13.8 0.3 0.96 9.3 0.1 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Rad17 PF03215.15 CCF35406.1 - 0.055 13.4 0.2 3.1 7.7 0.0 3.1 3 0 0 3 3 3 0 Rad17 P-loop domain NB-ARC PF00931.22 CCF35406.1 - 0.074 12.2 0.1 12 5.0 0.0 2.5 2 0 0 2 2 2 0 NB-ARC domain TsaE PF02367.17 CCF35406.1 - 0.084 12.9 0.0 5.9 6.9 0.0 2.6 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Adeno_IVa2 PF02456.15 CCF35406.1 - 0.17 10.6 0.2 11 4.7 0.1 2.3 2 0 0 2 2 2 0 Adenovirus IVa2 protein ATP_bind_1 PF03029.17 CCF35406.1 - 0.35 10.6 1.3 36 4.0 0.0 3.1 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein DUF87 PF01935.17 CCF35406.1 - 0.46 10.5 8.1 1.7 8.7 0.0 3.9 4 0 0 4 4 4 0 Helicase HerA, central domain AAA_27 PF13514.6 CCF35406.1 - 0.71 9.4 9.8 5.5 6.5 0.0 4.1 6 1 1 7 7 3 0 AAA domain AAA_17 PF13207.6 CCF35406.1 - 1.6 9.1 7.2 19 5.7 0.4 3.8 4 0 0 4 4 3 0 AAA domain SRP54 PF00448.22 CCF35406.1 - 1.8 8.1 6.8 4.7 6.8 0.1 3.6 4 0 0 4 4 4 0 SRP54-type protein, GTPase domain ORC_WH_C PF18137.1 CCF35407.1 - 0.11 12.5 0.0 0.12 12.4 0.0 1.2 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal ADH_N PF08240.12 CCF35412.1 - 3.8e-28 97.5 0.2 7.2e-28 96.6 0.2 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCF35412.1 - 6.1e-25 87.7 0.1 1e-24 87.0 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCF35412.1 - 1.6e-05 26.0 0.0 2.4e-05 25.4 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase adh_short PF00106.25 CCF35412.1 - 0.052 13.0 0.2 0.11 11.9 0.2 1.5 1 0 0 1 1 1 0 short chain dehydrogenase 2-Hacid_dh_C PF02826.19 CCF35412.1 - 0.18 11.2 0.2 0.42 9.9 0.2 1.6 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Actin PF00022.19 CCF35413.1 - 4.8e-88 295.5 0.0 2.2e-52 178.0 0.0 2.0 1 1 1 2 2 2 2 Actin NmrA PF05368.13 CCF35414.1 - 2e-20 73.4 0.0 2.5e-20 73.1 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CCF35414.1 - 1.6e-05 24.9 0.0 2.6e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CCF35414.1 - 8.7e-05 22.1 0.1 0.00018 21.0 0.0 1.6 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family KR PF08659.10 CCF35414.1 - 0.19 11.6 0.0 0.29 11.0 0.0 1.3 1 0 0 1 1 1 0 KR domain adh_short PF00106.25 CCF35415.1 - 1.3e-22 80.3 0.0 4.6e-19 68.6 0.0 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCF35415.1 - 1.2e-13 51.1 0.0 9.3e-11 41.7 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF35415.1 - 2.1e-07 31.0 0.0 3.4e-07 30.3 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF35415.1 - 0.00079 19.0 0.0 0.0013 18.3 0.0 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 CCF35415.1 - 0.0051 16.0 0.1 0.011 14.9 0.1 1.7 1 1 0 1 1 1 1 Male sterility protein Polysacc_synt_2 PF02719.15 CCF35415.1 - 0.0089 15.2 0.0 0.013 14.6 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 CCF35415.1 - 0.018 14.5 0.0 0.031 13.7 0.0 1.4 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 CCF35415.1 - 0.12 11.5 0.0 0.27 10.3 0.0 1.6 2 0 0 2 2 2 0 RmlD substrate binding domain THF_DHG_CYH_C PF02882.19 CCF35415.1 - 0.17 11.2 0.0 0.3 10.4 0.0 1.3 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Mito_carr PF00153.27 CCF35416.1 - 1.8e-51 172.0 5.4 2.9e-25 88.0 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 CCF35416.1 - 0.00098 18.4 1.6 0.12 11.5 0.0 2.5 2 1 0 2 2 2 2 Gammaproteobacterial serine protease DUF4097 PF13349.6 CCF35417.1 - 1e-07 31.6 2.5 2.8e-05 23.6 0.3 3.6 2 1 0 2 2 2 2 Putative adhesin Pkinase PF00069.25 CCF35418.1 - 7.2e-62 209.1 0.0 2.7e-61 207.3 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF35418.1 - 1.4e-27 96.6 0.0 2.8e-27 95.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 CCF35418.1 - 5.9e-10 39.3 0.0 2.3e-08 34.3 0.0 3.0 3 0 0 3 3 3 1 FHA domain Kinase-like PF14531.6 CCF35418.1 - 0.0021 17.4 0.0 0.0045 16.4 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Yop-YscD_cpl PF16697.5 CCF35418.1 - 0.0078 16.5 0.0 0.039 14.3 0.0 2.2 2 0 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain Kdo PF06293.14 CCF35418.1 - 0.044 13.1 0.1 0.086 12.2 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family YueH PF14166.6 CCF35418.1 - 0.16 11.9 0.1 0.54 10.2 0.0 2.0 2 0 0 2 2 2 0 YueH-like protein FTA2 PF13095.6 CCF35418.1 - 0.18 11.4 0.2 0.65 9.6 0.1 2.0 2 1 1 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 CCF35418.1 - 0.97 9.3 3.2 0.81 9.6 0.3 2.3 2 1 1 3 3 3 0 Phosphotransferase enzyme family CRT10 PF08728.10 CCF35419.1 - 6.1e-12 44.5 0.0 8.6e-12 44.1 0.0 1.1 1 0 0 1 1 1 1 CRT10 Cellulase PF00150.18 CCF35420.1 - 2.2e-37 129.0 0.2 2.6e-37 128.8 0.2 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Zn_clus PF00172.18 CCF35421.1 - 9.1e-09 35.3 13.1 1.6e-08 34.5 13.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PurL_C PF16904.5 CCF35421.1 - 0.1 12.9 0.0 0.22 11.8 0.0 1.5 1 0 0 1 1 1 0 Phosphoribosylformylglycinamidine synthase II C-terminus RGS PF00615.19 CCF35423.1 - 0.00013 22.2 0.2 0.043 14.1 0.0 2.3 2 0 0 2 2 2 2 Regulator of G protein signaling domain Pox_A14 PF05767.12 CCF35423.1 - 0.012 15.8 0.0 0.026 14.7 0.0 1.6 1 0 0 1 1 1 0 Poxvirus virion envelope protein A14 Glyco_transf_22 PF03901.17 CCF35424.1 - 8.8e-42 143.8 16.3 1.1e-41 143.4 16.3 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family Yos1 PF08571.10 CCF35425.1 - 2.2e-36 124.0 1.6 2.4e-36 123.8 1.6 1.0 1 0 0 1 1 1 1 Yos1-like UCH PF00443.29 CCF35426.1 - 9.3e-54 182.6 0.7 2e-53 181.5 0.0 1.9 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CCF35426.1 - 3.6e-25 89.2 3.1 2.1e-19 70.3 0.0 2.6 3 0 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase AAA_11 PF13086.6 CCF35426.1 - 0.038 13.8 7.4 0.062 13.1 7.4 1.4 1 0 0 1 1 1 0 AAA domain Macoilin PF09726.9 CCF35426.1 - 5.8 5.3 18.2 9 4.7 18.2 1.2 1 0 0 1 1 1 0 Macoilin family MAJIN PF15077.6 CCF35426.1 - 8.5 6.1 15.6 18 5.0 15.6 1.6 1 0 0 1 1 1 0 Membrane-anchored junction protein Presenilin PF01080.17 CCF35426.1 - 9.8 4.8 17.0 18 3.9 17.0 1.5 1 0 0 1 1 1 0 Presenilin Pan3_PK PF18101.1 CCF35427.1 - 5e-65 217.7 0.1 6.7e-65 217.2 0.1 1.2 1 0 0 1 1 1 1 Pan3 Pseudokinase domain LSM PF01423.22 CCF35428.1 - 2.6e-20 71.9 0.3 3.2e-20 71.6 0.3 1.1 1 0 0 1 1 1 1 LSM domain DUF150_C PF17384.2 CCF35428.1 - 0.087 13.0 0.0 0.13 12.4 0.0 1.3 1 0 0 1 1 1 0 RimP C-terminal SH3 domain IL2RB_N1 PF18707.1 CCF35429.1 - 0.00088 19.8 1.4 0.00088 19.8 1.4 1.1 1 0 0 1 1 1 1 Interleukin-2 receptor subunit beta N-terminal domain 1 VPS9 PF02204.18 CCF35430.1 - 5e-18 65.2 0.2 1.2e-17 64.0 0.2 1.7 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain Ank_2 PF12796.7 CCF35430.1 - 1.6e-14 54.3 0.5 8.5e-05 23.1 0.0 4.6 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CCF35430.1 - 2.6e-14 53.1 0.4 1.6e-10 41.0 0.0 4.8 4 1 1 5 5 5 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 CCF35430.1 - 3.2e-09 37.2 0.3 0.12 12.9 0.0 5.5 4 1 0 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCF35430.1 - 3.9e-07 29.9 1.0 0.77 10.5 0.0 5.4 5 0 0 5 5 5 2 Ankyrin repeat Ank PF00023.30 CCF35430.1 - 0.0012 19.2 0.1 1.4 9.5 0.0 4.3 4 0 0 4 4 4 1 Ankyrin repeat PX PF00787.24 CCF35430.1 - 0.17 11.9 0.5 0.55 10.2 0.0 2.1 3 0 0 3 3 3 0 PX domain NAD_binding_1 PF00175.21 CCF35431.1 - 9.1e-26 90.6 0.0 1.5e-25 89.9 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 CCF35431.1 - 4.4e-15 55.8 0.0 8.2e-15 55.0 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 CCF35431.1 - 2.4e-06 27.8 0.2 0.0078 16.3 0.0 2.5 3 0 0 3 3 3 2 Ferric reductase NAD binding domain APH PF01636.23 CCF35433.1 - 3.3e-06 27.2 0.8 2.6e-05 24.3 0.8 2.3 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CCF35433.1 - 0.0033 17.0 0.2 0.12 11.9 0.1 2.3 2 0 0 2 2 2 2 Choline/ethanolamine kinase 2OG-FeII_Oxy_3 PF13640.6 CCF35434.1 - 3.2e-07 31.2 0.1 8.8e-07 29.7 0.1 1.8 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily AIP3 PF03915.13 CCF35434.1 - 0.064 12.4 0.5 0.092 11.8 0.5 1.1 1 0 0 1 1 1 0 Actin interacting protein 3 TBP PF00352.21 CCF35436.1 - 9.1e-67 221.0 0.1 1e-32 111.9 0.0 2.2 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 CCF35436.1 - 8.6e-05 22.6 0.0 0.29 11.3 0.0 2.9 3 0 0 3 3 3 2 Domain of unknown function (DUF3378) DUF4295 PF14128.6 CCF35436.1 - 0.18 11.7 0.1 0.9 9.4 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4295) DAO PF01266.24 CCF35437.1 - 1.5e-41 143.2 0.2 1.8e-41 142.9 0.2 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CCF35437.1 - 4.5e-06 26.8 0.0 1.1e-05 25.6 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 CCF35437.1 - 5.5e-06 26.5 0.4 0.081 12.9 0.0 2.6 3 0 0 3 3 3 2 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 CCF35437.1 - 0.00028 20.2 0.0 0.9 8.7 0.0 2.7 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CCF35437.1 - 0.0084 15.2 0.0 0.82 8.7 0.0 2.3 2 0 0 2 2 2 1 FAD binding domain GIDA PF01134.22 CCF35437.1 - 0.011 14.8 0.0 0.041 13.0 0.0 1.8 2 0 0 2 2 2 0 Glucose inhibited division protein A Ribosomal_S25 PF03297.15 CCF35437.1 - 0.016 15.4 0.1 0.035 14.3 0.1 1.5 1 0 0 1 1 1 0 S25 ribosomal protein Thi4 PF01946.17 CCF35437.1 - 0.02 14.2 0.0 0.08 12.2 0.0 1.9 2 0 0 2 2 2 0 Thi4 family Glu_dehyd_C PF16912.5 CCF35437.1 - 0.022 14.2 0.0 0.045 13.2 0.0 1.5 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus Trp_halogenase PF04820.14 CCF35437.1 - 0.028 13.3 0.0 1.1 8.0 0.0 2.1 2 0 0 2 2 2 0 Tryptophan halogenase Sacchrp_dh_NADP PF03435.18 CCF35437.1 - 0.039 14.2 0.0 0.11 12.8 0.0 1.9 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain K_oxygenase PF13434.6 CCF35437.1 - 0.076 12.1 0.0 0.16 11.1 0.0 1.4 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Lycopene_cycl PF05834.12 CCF35437.1 - 0.15 11.1 0.1 2 7.4 0.0 2.1 2 0 0 2 2 2 0 Lycopene cyclase protein MCRA PF06100.11 CCF35437.1 - 0.25 10.1 0.0 0.43 9.3 0.0 1.3 1 0 0 1 1 1 0 MCRA family Bac_luciferase PF00296.20 CCF35439.1 - 3.5e-58 197.5 2.5 4.5e-58 197.1 2.5 1.1 1 0 0 1 1 1 1 Luciferase-like monooxygenase AcetylCoA_hydro PF02550.15 CCF35440.1 - 2.8e-45 154.7 0.0 4.6e-45 154.0 0.0 1.3 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase N-terminal domain AcetylCoA_hyd_C PF13336.6 CCF35440.1 - 1.1e-42 145.6 0.0 1.6e-42 145.1 0.0 1.3 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase C-terminal domain PH PF00169.29 CCF35441.1 - 4e-07 30.5 0.1 6e-06 26.7 0.0 2.6 2 0 0 2 2 2 1 PH domain PH_9 PF15410.6 CCF35441.1 - 0.0051 17.2 0.0 0.0051 17.2 0.0 2.7 3 0 0 3 3 3 1 Pleckstrin homology domain UPF0172 PF03665.13 CCF35441.1 - 0.5 10.4 12.7 0.93 9.5 12.7 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0172) GREB1 PF15782.5 CCF35441.1 - 1.1 6.3 19.0 1.9 5.5 19.0 1.3 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DDHD PF02862.17 CCF35441.1 - 4.8 7.3 15.1 0.66 10.1 10.4 2.0 2 0 0 2 2 2 0 DDHD domain AMP-binding PF00501.28 CCF35442.1 - 2.4e-55 187.9 0.0 2.9e-55 187.6 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.25 CCF35442.1 - 8.4e-06 26.1 0.1 3.2e-05 24.2 0.0 2.1 2 0 0 2 2 2 1 Phosphopantetheine attachment site RRM_1 PF00076.22 CCF35443.1 - 1e-16 60.5 0.0 1.6e-16 59.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Spc7 PF08317.11 CCF35443.1 - 0.034 13.0 3.8 0.041 12.8 3.8 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Nup35_RRM_2 PF14605.6 CCF35443.1 - 0.039 14.0 0.0 0.069 13.2 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif BLOC1_2 PF10046.9 CCF35443.1 - 0.042 14.2 0.5 0.063 13.6 0.5 1.3 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 RRM_occluded PF16842.5 CCF35443.1 - 0.12 12.3 0.0 0.24 11.3 0.0 1.5 1 1 0 1 1 1 0 Occluded RNA-recognition motif DUF724 PF05266.14 CCF35443.1 - 0.15 11.9 4.9 0.19 11.5 4.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF724) V_ATPase_I PF01496.19 CCF35443.1 - 0.23 9.4 2.3 0.27 9.1 2.3 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Fib_alpha PF08702.10 CCF35443.1 - 0.38 10.9 2.7 0.55 10.4 2.7 1.1 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF5089 PF17002.5 CCF35443.1 - 0.43 10.4 7.3 0.6 10.0 7.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5089) DUF3450 PF11932.8 CCF35443.1 - 0.53 9.6 5.6 0.7 9.2 5.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) EMP24_GP25L PF01105.24 CCF35443.1 - 0.66 9.9 3.3 0.9 9.5 3.3 1.2 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD UPF0242 PF06785.11 CCF35443.1 - 0.74 9.9 4.8 0.91 9.6 4.8 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DivIC PF04977.15 CCF35443.1 - 1.4 8.8 4.7 2.5 7.9 4.7 1.4 1 0 0 1 1 1 0 Septum formation initiator APG6_N PF17675.1 CCF35443.1 - 1.5 9.3 8.9 2.1 8.9 8.9 1.1 1 0 0 1 1 1 0 Apg6 coiled-coil region Ion_trans PF00520.31 CCF35444.1 - 7.4e-08 31.9 4.3 8.9e-08 31.7 4.3 1.1 1 0 0 1 1 1 1 Ion transport protein Sugar_tr PF00083.24 CCF35445.1 - 4.5e-128 427.9 20.8 5.1e-128 427.8 20.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF35445.1 - 4.4e-26 91.6 37.6 1.8e-20 73.2 14.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily RhodobacterPufX PF11511.8 CCF35445.1 - 0.081 12.5 3.2 1.8 8.2 0.1 3.3 3 0 0 3 3 3 0 Intrinsic membrane protein PufX YqfD PF06898.11 CCF35445.1 - 0.13 11.1 1.9 1.4 7.6 0.0 2.2 2 0 0 2 2 2 0 Putative stage IV sporulation protein YqfD His_Phos_2 PF00328.22 CCF35447.1 - 2.2e-65 221.5 0.0 2.6e-65 221.3 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) zf-LITAF-like PF10601.9 CCF35448.1 - 2.5e-08 34.1 3.5 0.0029 17.9 0.5 2.2 1 1 1 2 2 2 2 LITAF-like zinc ribbon domain Totivirus_coat PF05518.11 CCF35448.1 - 8.1 4.4 10.9 9.3 4.2 10.9 1.2 1 0 0 1 1 1 0 Totivirus coat protein Cyt-b5 PF00173.28 CCF35449.1 - 2.2e-15 56.5 0.0 5.3e-15 55.3 0.0 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain FAD_binding_1 PF00667.20 CCF35449.1 - 4.9e-11 42.6 0.0 1.8e-10 40.8 0.0 1.9 1 1 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 CCF35449.1 - 1.6e-08 35.2 0.0 5.1e-08 33.5 0.0 1.9 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain Glyco_hydro_12 PF01670.16 CCF35450.1 - 1.2e-21 77.7 0.4 1.7e-21 77.2 0.4 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 12 CBM_1 PF00734.18 CCF35450.1 - 1.6e-11 44.0 5.1 1.6e-11 44.0 5.1 3.0 2 0 0 2 2 2 1 Fungal cellulose binding domain Glyco_hydro_12 PF01670.16 CCF35451.1 - 5.9e-22 78.7 0.5 6.9e-22 78.5 0.5 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 12 MFS_1 PF07690.16 CCF35453.1 - 1.4e-42 145.9 15.2 1.4e-42 145.9 15.2 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF35453.1 - 1.4e-13 50.6 1.4 4.6e-13 48.9 1.6 1.7 1 1 0 1 1 1 1 Sugar (and other) transporter OATP PF03137.20 CCF35453.1 - 0.0041 15.5 0.6 0.013 13.8 0.2 2.0 1 1 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family DUF953 PF06110.11 CCF35454.1 - 1.9e-16 59.8 0.0 2.1e-16 59.6 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF953) Thioredoxin_9 PF14595.6 CCF35454.1 - 0.017 14.9 0.0 0.027 14.2 0.0 1.4 1 1 0 1 1 1 0 Thioredoxin FGE-sulfatase PF03781.16 CCF35455.1 - 2.3e-40 138.8 1.7 3.3e-40 138.3 1.7 1.1 1 0 0 1 1 1 1 Sulfatase-modifying factor enzyme 1 AAA_16 PF13191.6 CCF35455.1 - 6.5e-06 26.6 1.9 0.01 16.2 0.1 2.6 1 1 1 2 2 2 2 AAA ATPase domain AAA_25 PF13481.6 CCF35455.1 - 0.00045 19.8 0.0 0.0015 18.2 0.0 1.8 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 CCF35455.1 - 0.00051 20.0 0.0 0.0013 18.7 0.0 1.7 1 0 0 1 1 1 1 NACHT domain AAA_33 PF13671.6 CCF35455.1 - 0.0077 16.4 0.2 0.021 15.0 0.2 1.7 1 0 0 1 1 1 1 AAA domain cobW PF02492.19 CCF35455.1 - 0.013 15.1 0.0 0.021 14.4 0.0 1.2 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_29 PF13555.6 CCF35455.1 - 0.027 14.2 0.0 0.066 13.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.6 CCF35455.1 - 0.031 14.8 0.0 0.047 14.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 CCF35455.1 - 0.039 14.2 0.2 0.31 11.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 CCF35455.1 - 0.042 13.9 0.0 0.074 13.0 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE CbiA PF01656.23 CCF35455.1 - 0.042 13.9 0.6 0.09 12.8 0.6 1.5 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain ABC_tran PF00005.27 CCF35455.1 - 0.053 14.0 0.0 0.12 12.9 0.0 1.5 1 0 0 1 1 1 0 ABC transporter AAA_24 PF13479.6 CCF35455.1 - 0.056 13.2 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 CCF35455.1 - 0.07 13.7 0.0 0.16 12.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 CCF35455.1 - 0.081 12.0 0.0 0.13 11.3 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA PF00004.29 CCF35455.1 - 0.081 13.3 0.0 0.13 12.6 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CCF35455.1 - 0.084 12.9 0.1 0.15 12.1 0.1 1.3 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 CCF35455.1 - 0.087 13.2 0.0 0.15 12.5 0.0 1.3 1 0 0 1 1 1 0 RNA helicase Rad17 PF03215.15 CCF35455.1 - 0.14 12.1 0.0 0.47 10.4 0.0 1.7 2 0 0 2 2 2 0 Rad17 P-loop domain NTPase_1 PF03266.15 CCF35455.1 - 0.15 12.0 0.0 0.24 11.3 0.0 1.3 1 0 0 1 1 1 0 NTPase IstB_IS21 PF01695.17 CCF35455.1 - 0.15 11.8 0.0 0.28 10.9 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein Pox_A32 PF04665.12 CCF35455.1 - 0.15 11.5 0.1 0.25 10.8 0.1 1.2 1 0 0 1 1 1 0 Poxvirus A32 protein AAA_19 PF13245.6 CCF35455.1 - 0.15 12.3 0.0 0.38 11.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain G-alpha PF00503.20 CCF35455.1 - 0.17 11.0 0.0 0.3 10.2 0.0 1.3 1 0 0 1 1 1 0 G-protein alpha subunit ATPase PF06745.13 CCF35455.1 - 0.2 10.9 0.0 0.32 10.3 0.0 1.2 1 0 0 1 1 1 0 KaiC APS_kinase PF01583.20 CCF35455.1 - 0.23 11.4 0.0 0.38 10.6 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase MFS_1 PF07690.16 CCF35456.1 - 2.7e-27 95.6 28.5 2.7e-27 95.6 28.5 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Sel_put PF04328.13 CCF35456.1 - 0.17 12.0 0.0 0.33 11.0 0.0 1.5 1 0 0 1 1 1 0 Selenoprotein, putative Methyltransf_23 PF13489.6 CCF35457.1 - 6e-20 71.7 0.0 8.6e-20 71.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF35457.1 - 1.7e-11 44.1 0.0 1.3e-10 41.3 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF35457.1 - 1.2e-10 42.0 0.0 2.6e-10 40.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF35457.1 - 1.2e-08 35.4 0.0 4.3e-08 33.7 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF35457.1 - 1.7e-06 28.7 0.0 3.8e-05 24.4 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CCF35457.1 - 0.00087 18.9 0.0 0.0014 18.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain FtsJ PF01728.19 CCF35457.1 - 0.0036 17.4 0.0 0.0052 16.9 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_4 PF02390.17 CCF35457.1 - 0.0075 15.8 0.0 0.015 14.8 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase PrmA PF06325.13 CCF35457.1 - 0.0096 15.3 0.0 0.017 14.5 0.0 1.4 1 1 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_16 PF10294.9 CCF35457.1 - 0.043 13.5 0.0 0.067 12.9 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_2 PF00891.18 CCF35457.1 - 0.047 13.0 0.0 0.1 11.9 0.0 1.5 1 0 0 1 1 1 0 O-methyltransferase domain Beta-lactamase PF00144.24 CCF35458.1 - 8.5e-51 173.1 0.2 1.1e-50 172.8 0.2 1.1 1 0 0 1 1 1 1 Beta-lactamase Beta-lactamase2 PF13354.6 CCF35458.1 - 0.022 14.3 0.0 0.095 12.3 0.0 2.0 2 1 0 2 2 2 0 Beta-lactamase enzyme family adh_short PF00106.25 CCF35460.1 - 2.4e-25 89.1 0.5 2.6e-21 76.0 0.4 2.5 3 0 0 3 3 3 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCF35460.1 - 1.5e-12 47.6 0.0 9.2e-11 41.7 0.1 2.1 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF35460.1 - 7.8e-05 22.7 0.1 0.00014 21.8 0.1 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF35460.1 - 0.0055 16.2 0.1 0.029 13.8 0.1 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Methyltransf_PK PF05891.12 CCF35460.1 - 0.026 14.0 0.0 0.043 13.3 0.0 1.3 1 0 0 1 1 1 0 AdoMet dependent proline di-methyltransferase Polysacc_synt_2 PF02719.15 CCF35460.1 - 0.12 11.5 0.0 0.22 10.6 0.0 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein AAA PF00004.29 CCF35461.1 - 4.1e-18 66.1 0.0 6.9e-18 65.3 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CCF35461.1 - 0.00073 20.0 0.1 0.0021 18.5 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.12 CCF35461.1 - 0.0012 18.6 0.0 0.0024 17.6 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 CCF35461.1 - 0.0081 16.7 0.2 0.14 12.7 0.0 3.1 3 2 1 4 4 4 1 AAA domain AAA_22 PF13401.6 CCF35461.1 - 0.012 15.8 0.0 0.037 14.3 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 CCF35461.1 - 0.042 13.9 0.1 0.13 12.3 0.0 1.8 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_17 PF13207.6 CCF35461.1 - 0.087 13.2 0.0 0.22 12.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain NPR3 PF03666.13 CCF35461.1 - 4.4 6.0 4.7 90 1.7 4.9 2.3 3 0 0 3 3 3 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF2968 PF11180.8 CCF35463.1 - 0.068 12.8 0.2 0.13 11.9 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) Zw10 PF06248.13 CCF35463.1 - 0.1 11.1 0.1 0.16 10.5 0.1 1.2 1 0 0 1 1 1 0 Centromere/kinetochore Zw10 Transferase PF02458.15 CCF35464.1 - 8.3e-34 117.0 0.0 5.6e-16 58.2 0.0 3.0 3 0 0 3 3 3 3 Transferase family DUF1195 PF06708.11 CCF35464.1 - 0.015 15.0 0.0 0.027 14.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1195) Apo-VLDL-II PF05418.11 CCF35464.1 - 0.21 12.1 0.0 0.83 10.3 0.0 2.0 2 0 0 2 2 2 0 Apovitellenin I (Apo-VLDL-II) DUF2046 PF09755.9 CCF35466.1 - 0.0016 17.8 0.9 0.02 14.1 0.0 2.1 2 0 0 2 2 2 1 Uncharacterized conserved protein H4 (DUF2046) CASP_C PF08172.12 CCF35466.1 - 0.025 13.9 3.0 2 7.7 0.0 2.3 2 0 0 2 2 2 0 CASP C terminal DivIC PF04977.15 CCF35466.1 - 0.027 14.2 0.3 0.027 14.2 0.3 2.0 3 0 0 3 3 3 0 Septum formation initiator Nop14 PF04147.12 CCF35467.1 - 6 4.9 66.0 7.7 4.6 66.0 1.0 1 0 0 1 1 1 0 Nop14-like family UDPG_MGDP_dh_N PF03721.14 CCF35469.1 - 1.4e-49 168.2 0.0 2.4e-35 121.8 0.0 2.6 1 1 1 2 2 2 2 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh PF00984.19 CCF35469.1 - 1.9e-30 104.9 0.0 4.1e-30 103.8 0.0 1.6 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_C PF03720.15 CCF35469.1 - 1.7e-22 79.8 0.0 1.3e-17 64.1 0.0 3.4 3 0 0 3 3 3 2 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain NAD_binding_2 PF03446.15 CCF35469.1 - 0.009 16.2 0.0 0.36 11.0 0.0 2.8 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Sacchrp_dh_NADP PF03435.18 CCF35469.1 - 0.042 14.1 0.0 0.19 12.0 0.0 2.1 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Haem_degrading PF03928.14 CCF35470.1 - 4.3e-33 113.9 0.0 5.3e-33 113.6 0.0 1.1 1 0 0 1 1 1 1 Haem-degrading Glyco_hydro_7 PF00840.20 CCF35471.1 - 2.9e-141 471.1 0.7 3.7e-141 470.8 0.7 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 7 WD40 PF00400.32 CCF35472.1 - 8.8e-38 127.6 19.6 3.1e-07 31.0 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF35472.1 - 2.5e-14 53.3 0.0 0.00025 21.3 0.1 4.7 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CCF35472.1 - 3.7e-05 22.8 0.1 0.45 9.4 0.0 3.8 3 1 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 CCF35472.1 - 9.8e-05 22.3 0.0 0.11 12.3 0.0 2.8 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 CCF35472.1 - 0.00081 18.8 0.0 0.08 12.3 0.0 3.0 2 1 1 3 3 3 1 WD40-like domain Myb_DNA-bind_6 PF13921.6 CCF35473.1 - 7.5e-15 54.9 0.7 2.3e-14 53.3 0.7 2.0 1 0 0 1 1 1 1 Myb-like DNA-binding domain HSA PF07529.13 CCF35473.1 - 6.8e-13 48.7 0.5 6.8e-13 48.7 0.5 5.7 6 0 0 6 6 6 1 HSA Myb_DNA-binding PF00249.31 CCF35473.1 - 2.1e-05 24.6 0.3 6e-05 23.2 0.3 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain SAM_decarbox PF01536.16 CCF35474.1 - 7.1e-133 443.0 0.0 1.1e-132 442.4 0.0 1.3 1 1 0 1 1 1 1 Adenosylmethionine decarboxylase TYA PF01021.19 CCF35475.1 - 0.091 13.1 0.4 0.2 12.0 0.4 1.5 1 0 0 1 1 1 0 TYA transposon protein COesterase PF00135.28 CCF35476.1 - 4e-64 217.3 0.0 4.8e-64 217.1 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CCF35476.1 - 2e-06 27.8 0.0 2.6e-06 27.5 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCF35476.1 - 0.0068 17.0 4.1 0.012 16.2 0.6 2.0 2 0 0 2 2 2 1 Alpha/beta hydrolase family Asn_synthase PF00733.21 CCF35477.1 - 1.4e-17 64.4 1.9 5.5e-08 32.9 0.1 3.1 2 1 1 3 3 3 3 Asparagine synthase GATase_7 PF13537.6 CCF35477.1 - 2.2e-07 30.8 0.0 1.6e-06 28.0 0.0 2.4 1 1 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 CCF35477.1 - 0.028 14.6 0.0 0.087 13.0 0.0 1.8 1 1 0 1 1 1 0 Glutamine amidotransferase domain DUF3700 PF12481.8 CCF35477.1 - 0.085 12.3 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 Aluminium induced protein DUF3176 PF11374.8 CCF35478.1 - 6.6e-34 116.3 0.9 6.6e-34 116.3 0.9 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF3176) Mito_carr PF00153.27 CCF35479.1 - 2.5e-46 155.5 7.2 1.4e-16 60.2 0.2 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein CBS PF00571.28 CCF35481.1 - 1.6e-07 31.7 0.0 0.12 12.8 0.0 3.1 1 1 1 2 2 2 2 CBS domain DUF4350 PF14258.6 CCF35481.1 - 0.12 12.8 0.1 0.82 10.1 0.0 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4350) Epimerase PF01370.21 CCF35483.1 - 4.6e-22 78.7 0.0 6.1e-22 78.2 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 CCF35483.1 - 2.9e-09 36.4 0.0 4.9e-09 35.7 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 CCF35483.1 - 6.7e-08 32.3 0.0 9e-08 31.9 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 CCF35483.1 - 0.00046 19.3 0.0 0.0015 17.6 0.0 1.8 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Sacchrp_dh_NADP PF03435.18 CCF35483.1 - 0.0021 18.3 0.0 0.0042 17.3 0.0 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain TrkA_N PF02254.18 CCF35483.1 - 0.0062 16.8 0.0 0.017 15.4 0.0 1.7 1 0 0 1 1 1 1 TrkA-N domain KR PF08659.10 CCF35483.1 - 0.016 15.1 0.0 0.027 14.4 0.0 1.4 1 0 0 1 1 1 0 KR domain F_actin_cap_B PF01115.17 CCF35485.1 - 1.4e-104 349.0 0.0 1.6e-104 348.8 0.0 1.0 1 0 0 1 1 1 1 F-actin capping protein, beta subunit Rpn3_C PF08375.11 CCF35486.1 - 1.4e-25 89.5 1.7 1.4e-25 89.5 1.7 2.3 2 0 0 2 2 2 1 Proteasome regulatory subunit C-terminal PCI PF01399.27 CCF35486.1 - 1.9e-20 73.3 0.8 4.5e-20 72.1 0.0 2.1 3 0 0 3 3 3 1 PCI domain TPR_2 PF07719.17 CCF35486.1 - 0.0075 16.3 0.1 0.025 14.7 0.1 2.0 1 0 0 1 1 1 1 Tetratricopeptide repeat UDPGT PF00201.18 CCF35487.1 - 8.8e-08 31.4 0.0 1.3e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_trans_1_4 PF13692.6 CCF35487.1 - 0.017 15.6 0.0 0.044 14.2 0.0 1.7 1 0 0 1 1 1 0 Glycosyl transferases group 1 Glyco_tran_28_C PF04101.16 CCF35487.1 - 0.13 12.2 0.0 0.33 10.9 0.0 1.7 2 0 0 2 2 2 0 Glycosyltransferase family 28 C-terminal domain Putative_PNPOx PF01243.20 CCF35488.1 - 1.2e-05 25.4 0.0 0.0022 18.2 0.0 2.4 2 0 0 2 2 2 2 Pyridoxamine 5'-phosphate oxidase KCH PF16944.5 CCF35489.1 - 6e-101 337.4 9.9 7.1e-101 337.2 9.9 1.1 1 0 0 1 1 1 1 Fungal potassium channel NmrA PF05368.13 CCF35490.1 - 5.8e-15 55.5 0.0 7.7e-15 55.1 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CCF35490.1 - 1.3e-07 31.7 0.0 2.4e-07 30.8 0.0 1.4 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CCF35490.1 - 0.0022 17.5 0.0 0.0042 16.6 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 CCF35490.1 - 0.042 14.1 0.1 0.15 12.3 0.0 2.0 3 0 0 3 3 3 0 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 CCF35490.1 - 0.045 13.8 0.0 0.096 12.7 0.0 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase FSH1 PF03959.13 CCF35491.1 - 5e-32 111.3 0.0 9.8e-32 110.3 0.0 1.5 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Hydrolase_4 PF12146.8 CCF35491.1 - 0.014 14.7 0.0 4.5 6.5 0.0 3.3 3 1 0 3 3 3 0 Serine aminopeptidase, S33 HLH PF00010.26 CCF35494.1 - 0.093 12.7 0.2 1.3 9.0 0.1 2.3 2 0 0 2 2 2 0 Helix-loop-helix DNA-binding domain Peptidase_C1_2 PF03051.15 CCF35496.1 - 1.8e-126 422.4 0.0 2.1e-126 422.2 0.0 1.0 1 0 0 1 1 1 1 Peptidase C1-like family Peptidase_C1 PF00112.23 CCF35496.1 - 0.0018 18.4 0.0 1 9.4 0.0 2.5 2 1 0 2 2 2 2 Papain family cysteine protease TPT PF03151.16 CCF35497.1 - 4.6e-06 26.2 19.3 1.2e-05 24.8 19.3 1.6 1 1 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 CCF35497.1 - 1.5e-05 25.2 12.8 1.5e-05 25.2 12.8 2.2 2 0 0 2 2 2 1 EamA-like transporter family UPF0139 PF03669.13 CCF35497.1 - 0.11 12.4 0.2 0.33 10.8 0.2 1.9 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0139) 7tm_1 PF00001.21 CCF35497.1 - 0.72 9.1 11.0 1 8.6 8.9 2.4 1 1 0 2 2 2 0 7 transmembrane receptor (rhodopsin family) Brix PF04427.18 CCF35498.1 - 2.8e-24 86.3 0.3 4.5e-24 85.6 0.3 1.3 1 0 0 1 1 1 1 Brix domain BUD22 PF09073.10 CCF35498.1 - 1.3 8.2 26.6 2.1 7.6 26.6 1.2 1 0 0 1 1 1 0 BUD22 Sugar_tr PF00083.24 CCF35500.1 - 2.5e-87 293.6 24.1 2.9e-87 293.4 24.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF35500.1 - 6.2e-26 91.2 32.5 4.3e-24 85.1 24.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 CCF35500.1 - 6.9e-08 31.4 1.7 6.9e-08 31.4 1.7 1.9 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Cellulase PF00150.18 CCF35501.1 - 3.9e-31 108.5 3.2 5.2e-31 108.1 3.2 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) MFS_1 PF07690.16 CCF35502.1 - 3e-14 52.7 54.5 6.4e-09 35.2 16.0 2.3 2 1 1 3 3 3 2 Major Facilitator Superfamily TRI12 PF06609.13 CCF35502.1 - 6.4e-07 28.2 22.4 1.1e-06 27.4 22.4 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Methyltransf_23 PF13489.6 CCF35503.1 - 2.3e-13 50.3 0.0 3.6e-13 49.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF35503.1 - 0.0063 17.2 0.0 0.067 13.9 0.0 2.5 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF35503.1 - 0.05 14.4 0.0 0.29 11.9 0.0 2.2 2 1 0 2 2 2 0 Methyltransferase domain Methyltransf_11 PF08241.12 CCF35503.1 - 0.053 14.2 0.0 0.19 12.4 0.0 1.9 2 1 0 2 2 2 0 Methyltransferase domain POP1 PF06978.11 CCF35504.1 - 3.1e-75 252.7 16.9 3.1e-75 252.7 16.9 1.9 2 0 0 2 2 2 1 Ribonucleases P/MRP protein subunit POP1 POPLD PF08170.12 CCF35504.1 - 4.2e-30 103.9 0.2 4.2e-30 103.9 0.2 2.2 2 0 0 2 2 2 1 POPLD (NUC188) domain GCV_T_C PF08669.11 CCF35504.1 - 0.025 14.5 0.0 0.061 13.2 0.0 1.6 1 0 0 1 1 1 0 Glycine cleavage T-protein C-terminal barrel domain Peptidase_S8 PF00082.22 CCF35506.1 - 3.3e-32 111.9 8.7 4.3e-32 111.6 7.8 1.3 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 CCF35506.1 - 1.2e-15 57.9 0.1 2e-15 57.2 0.1 1.4 1 0 0 1 1 1 1 Peptidase inhibitor I9 Abhydrolase_6 PF12697.7 CCF35507.1 - 1.5e-09 38.8 0.0 0.00035 21.3 0.0 2.8 2 0 0 2 2 2 2 Alpha/beta hydrolase family PGAP1 PF07819.13 CCF35507.1 - 1.9e-08 34.3 0.0 0.0032 17.2 0.0 2.5 2 0 0 2 2 2 2 PGAP1-like protein DUF676 PF05057.14 CCF35507.1 - 8.4e-07 28.7 0.1 0.0014 18.2 0.0 2.5 2 0 0 2 2 2 2 Putative serine esterase (DUF676) Hydrolase_4 PF12146.8 CCF35507.1 - 2.4e-05 23.7 0.0 0.28 10.4 0.0 2.6 2 0 0 2 2 2 2 Serine aminopeptidase, S33 DUF900 PF05990.12 CCF35507.1 - 4.1e-05 23.2 0.3 0.015 14.8 0.0 2.9 2 1 1 3 3 3 1 Alpha/beta hydrolase of unknown function (DUF900) NACHT PF05729.12 CCF35507.1 - 0.00023 21.2 0.0 0.00065 19.7 0.0 1.8 1 0 0 1 1 1 1 NACHT domain LCAT PF02450.15 CCF35507.1 - 0.0018 17.5 0.0 0.61 9.2 0.0 2.5 2 0 0 2 2 2 2 Lecithin:cholesterol acyltransferase AAA_33 PF13671.6 CCF35507.1 - 0.0061 16.7 0.0 0.3 11.2 0.0 3.3 4 0 0 4 4 4 1 AAA domain Ank_5 PF13857.6 CCF35507.1 - 0.039 14.3 0.0 0.16 12.4 0.0 2.1 1 0 0 1 1 1 0 Ankyrin repeats (many copies) DUF829 PF05705.14 CCF35507.1 - 0.057 13.3 0.1 0.39 10.6 0.0 2.1 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF829) ABC_tran PF00005.27 CCF35507.1 - 0.065 13.8 0.0 0.33 11.4 0.0 2.1 2 0 0 2 2 2 0 ABC transporter MMR_HSR1 PF01926.23 CCF35507.1 - 0.093 12.8 0.0 0.35 11.0 0.0 2.0 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_16 PF13191.6 CCF35507.1 - 0.11 12.9 0.0 0.65 10.4 0.0 2.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_18 PF13238.6 CCF35507.1 - 0.12 12.9 0.0 0.36 11.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain Dynactin_p22 PF07426.11 CCF35507.1 - 0.17 11.8 0.3 1.4 8.8 0.2 2.1 2 0 0 2 2 2 0 Dynactin subunit p22 AAA_29 PF13555.6 CCF35507.1 - 0.18 11.6 0.2 1.2 9.0 0.0 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain DUF726 PF05277.12 CCF35507.1 - 0.2 10.5 0.1 10 4.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF726) NAD_binding_2 PF03446.15 CCF35508.1 - 1.8e-19 70.5 0.0 3.1e-19 69.7 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 CCF35508.1 - 3.1e-09 37.1 0.0 5.7e-09 36.3 0.0 1.5 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Fumerase_C PF05683.12 CCF35508.1 - 0.051 12.9 0.0 0.081 12.2 0.0 1.3 1 0 0 1 1 1 0 Fumarase C-terminus MFS_1 PF07690.16 CCF35509.1 - 4.6e-32 111.3 25.4 1.2e-31 110.0 25.9 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily PCI PF01399.27 CCF35510.1 - 3.9e-16 59.5 0.5 2.2e-15 57.1 0.1 2.3 3 0 0 3 3 3 1 PCI domain eIF3m_C_helix PF18005.1 CCF35510.1 - 2.3e-12 46.4 0.5 4.4e-12 45.5 0.5 1.5 1 0 0 1 1 1 1 eIF3 subunit M, C-terminal helix AnfO_nitrog PF09582.10 CCF35510.1 - 0.015 14.7 1.3 0.15 11.4 0.1 2.3 2 0 0 2 2 2 0 Iron only nitrogenase protein AnfO (AnfO_nitrog) Presenilin PF01080.17 CCF35510.1 - 9.1 4.9 6.0 13 4.4 6.0 1.2 1 0 0 1 1 1 0 Presenilin DUF3546 PF12066.8 CCF35511.1 - 1.4e-33 115.4 4.0 1.4e-33 115.4 4.0 2.7 4 0 0 4 4 4 1 Domain of unknown function (DUF3546) ARS2 PF04959.13 CCF35511.1 - 6.3e-13 49.5 0.3 2.4e-12 47.6 0.3 2.0 1 1 0 1 1 1 1 Arsenite-resistance protein 2 DUF4187 PF13821.6 CCF35511.1 - 3.5e-12 45.9 0.2 7.8e-12 44.8 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4187) TspO_MBR PF03073.15 CCF35512.1 - 3.8e-46 156.5 7.2 4.5e-46 156.2 7.2 1.1 1 0 0 1 1 1 1 TspO/MBR family Mito_carr PF00153.27 CCF35513.1 - 1.8e-57 191.2 0.1 9.3e-21 73.6 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DEAD PF00270.29 CCF35514.1 - 7.6e-47 159.3 0.0 2.2e-46 157.8 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF35514.1 - 3.8e-29 101.3 0.0 9.8e-28 96.7 0.1 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCF35514.1 - 3e-05 24.1 0.0 9e-05 22.5 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit PRAI PF00697.22 CCF35514.1 - 0.068 12.9 0.0 0.18 11.6 0.0 1.7 1 0 0 1 1 1 0 N-(5'phosphoribosyl)anthranilate (PRA) isomerase Mitoc_mL59 PF18126.1 CCF35515.1 - 2.4e-43 147.5 1.7 2.8e-43 147.3 1.7 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein mL59 zf-CSL PF05207.13 CCF35516.1 - 9.1e-20 70.1 0.6 1.5e-19 69.5 0.6 1.3 1 0 0 1 1 1 1 CSL zinc finger DnaJ PF00226.31 CCF35516.1 - 1.3e-13 50.9 0.7 2.5e-13 49.9 0.7 1.5 1 1 0 1 1 1 1 DnaJ domain 14-3-3 PF00244.20 CCF35517.1 - 1.4e-106 354.9 2.8 1.7e-106 354.7 2.8 1.0 1 0 0 1 1 1 1 14-3-3 protein TPR_12 PF13424.6 CCF35517.1 - 0.14 12.5 1.1 0.41 11.0 0.2 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.6 CCF35517.1 - 0.53 10.8 3.7 0.76 10.3 0.1 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat IATP PF04568.12 CCF35518.1 - 3.3e-29 101.2 1.0 3.7e-29 101.0 1.0 1.0 1 0 0 1 1 1 1 Mitochondrial ATPase inhibitor, IATP Pam16 PF03656.13 CCF35518.1 - 0.0044 17.0 0.1 0.0066 16.5 0.1 1.3 1 1 0 1 1 1 1 Pam16 DUF489 PF04356.12 CCF35518.1 - 0.027 14.5 0.4 0.03 14.3 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF489) NPV_P10 PF05531.12 CCF35518.1 - 0.13 12.8 0.9 0.18 12.3 0.9 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein XhlA PF10779.9 CCF35518.1 - 0.21 11.8 1.9 0.31 11.3 1.9 1.3 1 0 0 1 1 1 0 Haemolysin XhlA DUF1003 PF06210.11 CCF35518.1 - 0.43 10.7 1.6 0.6 10.2 1.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1003) Nsp1_C PF05064.13 CCF35519.1 - 1e-38 131.7 1.5 1e-38 131.7 1.5 1.6 2 0 0 2 2 2 1 Nsp1-like C-terminal region Nucleoporin_FG PF13634.6 CCF35519.1 - 3.1e-14 53.6 190.5 1.3e-05 25.9 34.5 8.1 2 1 4 6 6 5 3 Nucleoporin FG repeat region DUF4201 PF13870.6 CCF35519.1 - 0.023 14.4 1.1 0.17 11.6 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) Nup88 PF10168.9 CCF35519.1 - 0.037 11.8 1.2 0.047 11.5 1.2 1.1 1 0 0 1 1 1 0 Nuclear pore component DUF4200 PF13863.6 CCF35519.1 - 0.12 12.8 3.1 2.4 8.6 0.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) Laminin_II PF06009.12 CCF35519.1 - 0.49 10.4 4.1 14 5.7 0.1 2.5 2 1 0 2 2 2 0 Laminin Domain II PI_PP_I PF18363.1 CCF35519.1 - 0.69 10.1 3.9 0.35 11.1 0.8 1.9 2 1 0 2 2 2 0 Phosphoinositide phosphatase insertion domain NPV_P10 PF05531.12 CCF35519.1 - 0.7 10.4 2.6 3.4 8.2 0.1 2.8 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein APG6_N PF17675.1 CCF35519.1 - 0.76 10.3 6.7 1.1 9.8 6.3 1.4 1 1 0 1 1 1 0 Apg6 coiled-coil region Tropomyosin PF00261.20 CCF35519.1 - 7.6 5.8 10.4 0.96 8.8 2.1 2.1 1 1 1 2 2 2 0 Tropomyosin GAS PF13851.6 CCF35519.1 - 7.7 5.8 9.7 18 4.6 2.9 2.2 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding PhyH PF05721.13 CCF35520.1 - 5.6e-17 62.7 0.0 8.3e-17 62.1 0.0 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Methyltransf_11 PF08241.12 CCF35521.1 - 1.1e-23 83.6 0.1 1.9e-23 82.9 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF35521.1 - 5.8e-23 81.4 0.0 9.4e-23 80.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF35521.1 - 2.1e-22 79.6 0.0 2.8e-22 79.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCF35521.1 - 4.8e-16 58.8 0.0 7.4e-16 58.2 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 CCF35521.1 - 1.9e-15 57.4 0.0 3.2e-15 56.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF35521.1 - 3.9e-15 56.1 0.0 5.4e-15 55.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 CCF35521.1 - 7.9e-07 29.0 0.1 1.8e-06 27.9 0.0 1.6 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 CCF35521.1 - 3.1e-05 23.6 0.0 4.5e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain MetW PF07021.12 CCF35521.1 - 4.8e-05 23.0 0.0 0.00024 20.7 0.0 1.9 1 1 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_24 PF13578.6 CCF35521.1 - 0.00092 20.2 0.1 0.0024 18.9 0.0 1.7 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_PK PF05891.12 CCF35521.1 - 0.0014 18.2 0.0 0.0043 16.6 0.0 1.7 2 0 0 2 2 2 1 AdoMet dependent proline di-methyltransferase Methyltransf_29 PF03141.16 CCF35521.1 - 0.0027 16.3 0.0 0.0041 15.8 0.0 1.2 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase DREV PF05219.12 CCF35521.1 - 0.013 14.6 0.0 0.028 13.5 0.0 1.5 1 1 0 1 1 1 0 DREV methyltransferase RrnaAD PF00398.20 CCF35521.1 - 0.019 14.1 0.0 0.028 13.5 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase CMAS PF02353.20 CCF35521.1 - 0.022 14.1 0.0 0.029 13.7 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_32 PF13679.6 CCF35521.1 - 0.026 14.5 0.0 0.041 13.9 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain PrmA PF06325.13 CCF35521.1 - 0.055 12.8 0.0 0.08 12.3 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_4 PF02390.17 CCF35521.1 - 0.11 11.9 0.0 0.21 11.1 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase p450 PF00067.22 CCF35522.1 - 4.6e-33 114.7 0.0 6.3e-33 114.2 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 KR PF08659.10 CCF35523.1 - 1.7e-56 191.0 0.0 8.9e-56 188.6 0.0 2.3 2 0 0 2 2 2 1 KR domain PS-DH PF14765.6 CCF35523.1 - 1.4e-49 169.0 0.7 2.2e-49 168.3 0.7 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 CCF35523.1 - 1.5e-47 162.7 0.0 1.1e-46 159.8 0.0 2.1 2 0 0 2 2 2 1 Acyl transferase domain Methyltransf_12 PF08242.12 CCF35523.1 - 1.3e-19 70.8 0.0 3.3e-19 69.5 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF35523.1 - 1.8e-13 51.0 0.0 1.1e-12 48.5 0.0 2.5 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF35523.1 - 9.8e-13 48.3 0.0 2.3e-12 47.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain ADH_zinc_N_2 PF13602.6 CCF35523.1 - 2e-12 48.3 0.0 1.5e-10 42.3 0.0 3.1 2 0 0 2 2 2 1 Zinc-binding dehydrogenase adh_short PF00106.25 CCF35523.1 - 3.7e-12 46.1 1.2 3.8e-11 42.8 0.0 2.8 3 1 0 3 3 3 1 short chain dehydrogenase Methyltransf_11 PF08241.12 CCF35523.1 - 1.6e-11 44.7 0.0 5.1e-11 43.1 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain ADH_zinc_N PF00107.26 CCF35523.1 - 1.9e-10 40.8 0.1 2.8e-09 37.0 0.0 2.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Methyltransf_31 PF13847.6 CCF35523.1 - 1.8e-09 37.6 0.0 4e-09 36.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain adh_short_C2 PF13561.6 CCF35523.1 - 4.4e-09 36.2 0.4 1.1e-06 28.4 0.0 2.5 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KAsynt_C_assoc PF16197.5 CCF35523.1 - 5.2e-07 30.1 0.0 0.0014 19.1 0.0 2.7 2 0 0 2 2 2 2 Ketoacyl-synthetase C-terminal extension Ubie_methyltran PF01209.18 CCF35523.1 - 3.1e-05 23.4 0.0 6.3e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family SAT PF16073.5 CCF35523.1 - 0.0016 18.2 0.0 0.0055 16.5 0.0 2.0 1 0 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis MTS PF05175.14 CCF35523.1 - 0.038 13.5 0.0 0.074 12.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain PCMT PF01135.19 CCF35523.1 - 0.048 13.4 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_24 PF13578.6 CCF35523.1 - 0.12 13.5 0.0 0.36 11.9 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain Peptidase_M28 PF04389.17 CCF35524.1 - 3.3e-38 131.4 0.0 4.1e-38 131.1 0.0 1.0 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 CCF35524.1 - 7e-12 45.5 0.2 7e-11 42.2 0.2 1.9 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M42 PF05343.14 CCF35524.1 - 0.00095 18.3 0.0 0.0017 17.5 0.0 1.6 1 1 0 1 1 1 1 M42 glutamyl aminopeptidase MFS_1 PF07690.16 CCF35525.1 - 1.1e-31 110.0 77.4 1.7e-26 93.0 52.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF35525.1 - 0.038 12.9 40.4 0.092 11.6 12.3 2.1 2 0 0 2 2 2 0 Sugar (and other) transporter Cu_amine_oxid PF01179.20 CCF35526.1 - 1.1e-162 541.6 0.0 1.6e-162 541.1 0.0 1.2 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN2 PF02727.16 CCF35526.1 - 5.9e-10 39.3 0.1 1e-09 38.5 0.1 1.4 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain Cu_amine_oxidN3 PF02728.16 CCF35526.1 - 0.00029 21.2 0.0 0.0011 19.4 0.0 1.9 2 0 0 2 2 2 1 Copper amine oxidase, N3 domain DUF2917 PF11142.8 CCF35526.1 - 0.14 11.6 0.2 6.7 6.2 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2917) Cobalamin_bind PF01122.19 CCF35526.1 - 0.25 10.2 0.4 1.1 8.1 0.1 1.8 2 0 0 2 2 2 0 Eukaryotic cobalamin-binding protein Methyltransf_23 PF13489.6 CCF35528.1 - 3.5e-13 49.7 0.0 5.1e-13 49.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF35528.1 - 0.00071 20.2 0.0 0.0013 19.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF35528.1 - 0.0013 19.4 0.0 0.0023 18.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF35528.1 - 0.0017 18.1 0.0 0.004 17.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF35528.1 - 0.019 15.7 0.0 0.037 14.8 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain DUF3489 PF11994.8 CCF35528.1 - 0.023 14.8 0.0 0.04 14.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3489) Peptidase_S8 PF00082.22 CCF35533.1 - 8.3e-17 61.4 0.2 1.7e-16 60.4 0.2 1.5 1 0 0 1 1 1 1 Subtilase family fn3_5 PF06280.12 CCF35533.1 - 1.5e-12 48.2 0.0 2.9e-12 47.3 0.0 1.4 1 0 0 1 1 1 1 Fn3-like domain Phos_pyr_kin PF08543.12 CCF35534.1 - 3.1e-11 43.1 0.0 8.4e-11 41.7 0.0 1.7 2 0 0 2 2 2 1 Phosphomethylpyrimidine kinase PfkB PF00294.24 CCF35534.1 - 7.1e-07 28.8 0.0 7.1e-07 28.8 0.0 1.9 2 0 0 2 2 2 1 pfkB family carbohydrate kinase dUTPase PF00692.19 CCF35535.1 - 2e-44 150.4 0.0 2.5e-44 150.1 0.0 1.1 1 0 0 1 1 1 1 dUTPase CENP-K PF11802.8 CCF35536.1 - 2.3e-10 40.5 7.3 0.00033 20.3 0.0 2.5 2 1 0 2 2 2 2 Centromere-associated protein K PIN_8 PF18476.1 CCF35536.1 - 0.0037 17.2 2.2 0.017 15.0 1.2 2.1 2 0 0 2 2 2 1 PIN like domain DUF2205 PF10224.9 CCF35536.1 - 0.024 14.6 4.4 0.19 11.8 0.0 2.9 2 0 0 2 2 2 0 Short coiled-coil protein PSI_PsaF PF02507.15 CCF35536.1 - 0.056 13.3 2.4 1.4 8.7 0.5 2.5 2 1 0 2 2 2 0 Photosystem I reaction centre subunit III Rbsn PF11464.8 CCF35536.1 - 0.068 12.9 7.4 0.92 9.3 0.6 4.6 4 0 0 4 4 4 0 Rabenosyn Rab binding domain Atg14 PF10186.9 CCF35536.1 - 0.077 12.1 14.4 1.7 7.7 0.1 2.2 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DinB_2 PF12867.7 CCF35536.1 - 0.34 11.4 13.4 7.5 7.1 0.2 3.8 1 1 2 3 3 3 0 DinB superfamily Lzipper-MIP1 PF14389.6 CCF35536.1 - 0.43 10.9 11.7 4.1 7.8 0.4 2.7 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 MIF4G_like_2 PF09090.11 CCF35536.1 - 0.54 9.7 5.1 0.42 10.1 2.4 1.9 2 0 0 2 2 2 0 MIF4G like Mod_r PF07200.13 CCF35536.1 - 1.1 9.4 24.8 4.7 7.3 14.7 3.7 3 1 0 3 3 3 0 Modifier of rudimentary (Mod(r)) protein UPF0242 PF06785.11 CCF35536.1 - 2.3 8.3 15.7 6.3 6.9 9.7 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Exonuc_VII_L PF02601.15 CCF35536.1 - 3.6 7.1 16.7 10 5.6 16.7 1.7 1 1 0 1 1 1 0 Exonuclease VII, large subunit TMPIT PF07851.13 CCF35536.1 - 6.4 5.9 6.0 33 3.6 0.0 2.3 2 0 0 2 2 2 0 TMPIT-like protein Prefoldin PF02996.17 CCF35536.1 - 7.2 6.6 11.4 1.4 8.9 0.5 3.1 2 1 1 3 3 3 0 Prefoldin subunit DSPc PF00782.20 CCF35537.1 - 4.8e-10 39.4 0.0 6.8e-10 38.9 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 CCF35537.1 - 0.0008 19.0 0.0 0.0011 18.6 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 CCF35537.1 - 0.0015 18.7 0.0 0.0024 18.0 0.0 1.4 1 0 0 1 1 1 1 Inositol hexakisphosphate MIF4G_like PF09088.11 CCF35538.1 - 9.2e-91 302.8 0.1 1.4e-90 302.2 0.1 1.3 1 0 0 1 1 1 1 MIF4G like MIF4G_like_2 PF09090.11 CCF35538.1 - 7.4e-74 248.6 0.0 1.1e-73 248.0 0.0 1.3 1 0 0 1 1 1 1 MIF4G like Tape_meas_lam_C PF09718.10 CCF35538.1 - 0.063 13.4 1.1 0.13 12.4 0.1 1.9 2 0 0 2 2 2 0 Lambda phage tail tape-measure protein (Tape_meas_lam_C) WD40 PF00400.32 CCF35539.1 - 2.2e-22 78.9 11.1 5.5e-08 33.3 0.1 7.0 7 0 0 7 7 7 5 WD domain, G-beta repeat NLE PF08154.12 CCF35539.1 - 9.1e-16 58.1 0.4 2.2e-15 56.9 0.4 1.7 1 0 0 1 1 1 1 NLE (NUC135) domain Nup160 PF11715.8 CCF35539.1 - 6.7e-08 31.6 1.1 0.00028 19.7 0.2 3.1 2 1 0 3 3 3 3 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 CCF35539.1 - 0.1 11.6 0.0 0.47 9.4 0.0 2.1 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Chitin_synth_2 PF03142.15 CCF35542.1 - 7.3e-25 87.6 5.1 2.7e-23 82.4 3.9 2.4 2 0 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 CCF35542.1 - 1.9e-18 67.1 3.1 2.3e-17 63.6 4.9 2.0 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 CCF35542.1 - 1.4e-13 51.3 0.0 3.2e-13 50.1 0.0 1.7 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 CCF35542.1 - 0.0015 18.4 0.3 0.23 11.2 0.0 2.5 2 0 0 2 2 2 2 Glycosyl transferase family 2 DUF3439 PF11921.8 CCF35542.1 - 1.3 9.0 4.8 3.9 7.5 4.8 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) HSP70 PF00012.20 CCF35543.1 - 1e-164 549.1 5.3 1e-164 549.1 5.3 1.8 1 1 1 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.13 CCF35543.1 - 4.9e-12 45.3 0.6 3.5e-11 42.5 0.1 2.1 2 0 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.6 CCF35543.1 - 0.014 15.8 6.5 0.32 11.5 0.1 3.1 3 1 0 3 3 3 0 Cell division protein FtsA GTP_EFTU PF00009.27 CCF35544.1 - 1.3e-34 119.4 0.0 6.7e-34 117.1 0.0 2.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 CCF35544.1 - 1.2e-19 70.4 0.0 3e-19 69.1 0.0 1.7 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D4 PF14578.6 CCF35544.1 - 1.7e-08 34.2 0.5 7.8e-08 32.1 0.5 2.2 1 0 0 1 1 1 1 Elongation factor Tu domain 4 MMR_HSR1 PF01926.23 CCF35544.1 - 5.6e-07 29.7 0.2 1e-05 25.6 0.0 2.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 CCF35544.1 - 8.3e-07 29.3 11.8 1.3e-06 28.7 0.1 3.5 4 0 0 4 4 4 2 Elongation factor Tu domain 2 Roc PF08477.13 CCF35544.1 - 0.00045 20.4 0.0 0.0013 18.9 0.0 1.8 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase ATP_bind_1 PF03029.17 CCF35544.1 - 0.0068 16.2 0.0 0.0068 16.2 0.0 2.3 3 0 0 3 3 3 1 Conserved hypothetical ATP binding protein AAA_22 PF13401.6 CCF35544.1 - 0.13 12.6 0.1 1.5 9.1 0.1 2.7 1 1 0 1 1 1 0 AAA domain SNF2_N PF00176.23 CCF35545.1 - 2.9e-71 240.0 0.1 5.2e-71 239.2 0.0 1.4 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CCF35545.1 - 1.5e-13 51.1 0.0 5.6e-13 49.2 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-RING_5 PF14634.6 CCF35545.1 - 5.5e-08 32.6 2.6 9.5e-08 31.9 2.6 1.4 1 0 0 1 1 1 1 zinc-RING finger domain DEAD PF00270.29 CCF35545.1 - 8.8e-07 28.9 0.0 2.3e-06 27.5 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Prok-RING_4 PF14447.6 CCF35545.1 - 0.0039 17.0 3.3 0.016 15.0 3.3 2.0 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 CCF35545.1 - 0.0046 17.3 1.0 0.011 16.0 1.0 1.7 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 CCF35545.1 - 0.023 14.6 2.7 0.11 12.4 2.7 2.1 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CCF35545.1 - 0.034 14.0 3.1 0.078 12.8 0.8 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CCF35545.1 - 4.8 7.3 5.4 1.8 8.7 1.9 2.1 1 1 1 2 2 2 0 RING-type zinc-finger zf-C3HC4_2 PF13923.6 CCF35545.1 - 9.3 6.2 6.6 0.97 9.3 0.3 2.4 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Cyt-b5 PF00173.28 CCF35546.1 - 1.6e-17 63.4 0.0 3.1e-17 62.5 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain FA_desaturase PF00487.24 CCF35546.1 - 3.3e-17 63.2 14.4 3.3e-17 63.2 14.4 1.6 1 1 0 1 1 1 1 Fatty acid desaturase Herpes_capsid PF06112.11 CCF35547.1 - 0.0036 17.4 4.5 0.0053 16.8 4.5 1.2 1 0 0 1 1 1 1 Gammaherpesvirus capsid protein Period_C PF12114.8 CCF35547.1 - 3.3 7.3 9.7 3.9 7.0 9.7 1.2 1 0 0 1 1 1 0 Period protein 2/3C-terminal region PaRep2a PF07903.11 CCF35548.1 - 0.019 14.8 0.1 0.032 14.1 0.1 1.2 1 0 0 1 1 1 0 PaRep2a protein CT_A_B PF02626.15 CCF35549.1 - 4.3e-79 265.9 0.0 6.7e-79 265.2 0.0 1.3 1 0 0 1 1 1 1 Carboxyltransferase domain, subdomain A and B CPSase_L_D2 PF02786.17 CCF35549.1 - 1.3e-53 181.6 0.0 3.2e-53 180.4 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 CCF35549.1 - 1.6e-38 131.7 0.1 5.1e-38 130.0 0.1 1.9 2 0 0 2 2 2 1 Biotin carboxylase, N-terminal domain CT_C_D PF02682.16 CCF35549.1 - 9.9e-32 110.3 0.0 2.3e-31 109.1 0.0 1.6 1 0 0 1 1 1 1 Carboxyltransferase domain, subdomain C and D Biotin_carb_C PF02785.19 CCF35549.1 - 6.9e-31 106.6 0.0 1.4e-30 105.6 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 CCF35549.1 - 5.4e-10 39.0 5.5 3.9e-09 36.2 3.0 3.0 4 0 0 4 4 4 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 CCF35549.1 - 3e-05 23.7 0.0 9e-05 22.1 0.0 1.7 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_5 PF13549.6 CCF35549.1 - 0.0024 17.4 0.0 0.0056 16.2 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp PF02222.22 CCF35549.1 - 0.018 14.6 0.0 0.035 13.7 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain HET PF06985.11 CCF35550.1 - 4.4e-07 30.4 0.4 7.6e-07 29.6 0.4 1.3 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) MatE PF01554.18 CCF35551.1 - 7.7e-54 181.7 35.2 6.1e-35 120.2 11.9 2.3 2 0 0 2 2 2 2 MatE DUF5389 PF17364.2 CCF35551.1 - 0.026 14.6 0.3 0.026 14.6 0.3 2.5 3 1 0 3 3 3 0 Family of unknown function (DUF5389) Como_SCP PF02248.16 CCF35551.1 - 0.032 13.8 0.2 0.063 12.9 0.2 1.4 1 0 0 1 1 1 0 Small coat protein Img2 PF05046.14 CCF35552.1 - 2.5e-20 72.5 0.0 3.2e-20 72.2 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) ARID PF01388.21 CCF35553.1 - 4.2e-19 69.0 0.3 1.7e-18 67.0 0.0 2.3 2 0 0 2 2 2 1 ARID/BRIGHT DNA binding domain CDC73_N PF16050.5 CCF35553.1 - 0.17 11.1 5.7 0.07 12.4 0.3 2.1 2 0 0 2 2 2 0 Paf1 complex subunit CDC73 N-terminal KR PF08659.10 CCF35556.1 - 3.3e-42 144.4 0.2 6.4e-42 143.5 0.2 1.5 1 0 0 1 1 1 1 KR domain adh_short PF00106.25 CCF35556.1 - 7.4e-14 51.6 0.1 3.3e-13 49.6 0.1 2.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF35556.1 - 8.8e-11 41.8 0.5 2.3e-10 40.4 0.1 1.9 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase ADH_zinc_N PF00107.26 CCF35556.1 - 7.2e-05 22.8 1.6 0.0012 18.8 0.1 3.1 3 1 0 3 3 3 1 Zinc-binding dehydrogenase Sacchrp_dh_NADP PF03435.18 CCF35556.1 - 0.0014 18.9 0.5 0.0035 17.6 0.1 1.8 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain ADH_N PF08240.12 CCF35556.1 - 0.022 14.7 0.0 0.047 13.6 0.0 1.6 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain SMC_N PF02463.19 CCF35557.1 - 2.7e-08 33.5 3.8 5e-08 32.6 3.8 1.4 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 CCF35557.1 - 3.1e-07 30.5 0.0 1.2e-06 28.6 0.0 2.1 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_21 PF13304.6 CCF35557.1 - 0.00077 19.4 9.9 0.0014 18.5 6.8 2.9 2 1 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system FliJ PF02050.16 CCF35557.1 - 0.07 13.4 57.3 0.24 11.6 12.4 6.8 3 3 2 6 6 6 0 Flagellar FliJ protein Occludin_ELL PF07303.13 CCF35557.1 - 0.086 13.6 0.3 0.086 13.6 0.3 6.4 3 3 4 8 8 8 0 Occludin homology domain HCMV_UL139 PF12507.8 CCF35557.1 - 5.9 7.3 17.3 0.051 14.0 5.2 3.6 3 2 0 3 3 3 0 Human Cytomegalovirus UL139 protein PPP4R2 PF09184.11 CCF35558.1 - 7.4e-07 29.0 12.1 7.4e-07 29.0 12.1 3.6 1 1 2 3 3 3 1 PPP4R2 Pup PF05639.11 CCF35558.1 - 0.11 13.5 0.1 0.11 13.5 0.1 4.6 3 1 0 4 4 4 0 Pup-like protein RRF PF01765.19 CCF35559.1 - 1.5e-26 93.3 3.0 1.9e-26 92.9 3.0 1.1 1 0 0 1 1 1 1 Ribosome recycling factor DUF3533 PF12051.8 CCF35561.1 - 7.6e-99 331.2 4.5 8.7e-99 331.0 4.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3533) ABC2_membrane_3 PF12698.7 CCF35561.1 - 0.08 12.0 15.4 0.0078 15.4 10.3 1.8 2 0 0 2 2 2 0 ABC-2 family transporter protein DUF3046 PF11248.8 CCF35561.1 - 0.1 13.0 0.0 0.24 11.8 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3046) GTP_cyclohydro2 PF00925.20 CCF35563.1 - 1.3e-36 125.7 0.1 1.6e-36 125.4 0.1 1.1 1 0 0 1 1 1 1 GTP cyclohydrolase II AA_permease_2 PF13520.6 CCF35564.1 - 4.6e-60 203.6 28.0 1.1e-59 202.4 26.3 2.4 1 1 1 2 2 2 1 Amino acid permease AA_permease PF00324.21 CCF35564.1 - 4.5e-09 35.4 18.5 4.5e-09 35.4 18.5 3.1 2 1 0 2 2 2 2 Amino acid permease Shikimate_dh_N PF08501.11 CCF35565.1 - 2.3e-22 79.0 0.0 6.2e-22 77.6 0.0 1.8 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain DHquinase_I PF01487.15 CCF35565.1 - 2.9e-22 80.0 0.0 4.9e-22 79.3 0.0 1.4 1 0 0 1 1 1 1 Type I 3-dehydroquinase SKI PF01202.22 CCF35565.1 - 8.5e-10 39.0 0.6 1.4e-09 38.3 0.2 1.6 2 0 0 2 2 2 1 Shikimate kinase SDH_C PF18317.1 CCF35565.1 - 7.9e-09 35.1 0.2 1.6e-08 34.1 0.2 1.6 1 0 0 1 1 1 1 Shikimate 5'-dehydrogenase C-terminal domain Shikimate_DH PF01488.20 CCF35565.1 - 1e-06 28.8 0.1 2.3e-06 27.7 0.1 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase AAA_25 PF13481.6 CCF35565.1 - 0.00078 19.1 0.0 0.091 12.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain F420_oxidored PF03807.17 CCF35565.1 - 0.084 13.5 0.0 0.31 11.7 0.0 1.9 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Sacchrp_dh_NADP PF03435.18 CCF35565.1 - 0.12 12.6 0.0 0.33 11.2 0.0 1.7 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Fungal_trans PF04082.18 CCF35566.1 - 1.3e-11 44.1 0.0 1.9e-11 43.5 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF35566.1 - 0.00021 21.3 1.5 0.00048 20.2 1.5 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF1688 PF07958.11 CCF35566.1 - 0.047 12.4 0.0 0.069 11.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1688) LMBR1 PF04791.16 CCF35566.1 - 0.18 10.6 0.8 0.28 10.0 0.8 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Sugar_tr PF00083.24 CCF35567.1 - 3.1e-138 461.4 21.0 3.6e-138 461.2 21.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF35567.1 - 1.4e-22 80.2 32.2 1.4e-22 80.2 32.2 2.2 1 1 1 2 2 2 1 Major Facilitator Superfamily Slu7 PF11708.8 CCF35568.1 - 2.4e-06 27.5 0.8 2.4e-06 27.5 0.8 1.8 2 0 0 2 2 2 1 Pre-mRNA splicing Prp18-interacting factor zf-CCHC_4 PF14392.6 CCF35568.1 - 0.008 15.9 0.4 0.013 15.2 0.4 1.3 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.23 CCF35568.1 - 0.031 14.4 2.7 0.055 13.6 2.7 1.4 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_5 PF14787.6 CCF35568.1 - 0.22 11.2 3.1 0.4 10.4 3.1 1.4 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger DNA_pol_B PF00136.21 CCF35569.1 - 9.6e-104 347.6 0.0 1.3e-103 347.2 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 CCF35569.1 - 5.4e-20 71.8 0.0 9.9e-11 41.3 0.0 2.5 2 0 0 2 2 2 2 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 CCF35569.1 - 2.2e-15 56.9 8.4 2.2e-15 56.9 8.4 1.8 2 0 0 2 2 2 1 C4-type zinc-finger of DNA polymerase delta XkdW PF09636.10 CCF35569.1 - 0.093 12.8 0.2 0.29 11.2 0.2 1.8 1 0 0 1 1 1 0 XkdW protein zf-CHCC PF10276.9 CCF35570.1 - 2.2e-15 56.4 2.2 3.3e-15 55.9 2.2 1.3 1 0 0 1 1 1 1 Zinc-finger domain MFS_1 PF07690.16 CCF35571.1 - 3e-30 105.3 25.5 8.9e-26 90.6 4.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MPP6 PF10175.9 CCF35572.1 - 2.1e-07 31.5 10.9 0.00065 20.2 0.8 2.9 2 1 1 3 3 3 2 M-phase phosphoprotein 6 zf-CCHC PF00098.23 CCF35572.1 - 2.4e-05 24.2 4.4 3.8e-05 23.6 4.4 1.3 1 0 0 1 1 1 1 Zinc knuckle Nop14 PF04147.12 CCF35572.1 - 0.0064 14.8 13.5 0.0088 14.3 13.5 1.1 1 0 0 1 1 1 1 Nop14-like family zf-CCHC_2 PF13696.6 CCF35572.1 - 0.044 13.6 2.1 0.078 12.8 2.1 1.4 1 0 0 1 1 1 0 Zinc knuckle Cwf_Cwc_15 PF04889.12 CCF35572.1 - 0.05 13.3 15.2 0.018 14.8 11.5 1.9 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein SpoIIIAH PF12685.7 CCF35572.1 - 1.2 9.0 8.4 2.2 8.0 8.4 1.5 1 0 0 1 1 1 0 SpoIIIAH-like protein DNA_pol_phi PF04931.13 CCF35572.1 - 1.7 6.7 8.4 2.3 6.2 8.4 1.1 1 0 0 1 1 1 0 DNA polymerase phi DUF4692 PF15763.5 CCF35572.1 - 6 7.3 11.0 9.5 6.7 9.4 2.1 2 0 0 2 2 2 0 Regulator of human erythroid cell expansion (RHEX) FAD_binding_2 PF00890.24 CCF35573.1 - 2.3e-83 280.6 1.0 2.8e-83 280.3 1.0 1.1 1 0 0 1 1 1 1 FAD binding domain Cyt-b5 PF00173.28 CCF35573.1 - 1.6e-21 76.2 0.0 1.1e-20 73.6 0.0 2.4 3 0 0 3 3 3 1 Cytochrome b5-like Heme/Steroid binding domain DAO PF01266.24 CCF35573.1 - 2.7e-14 53.5 0.6 5e-14 52.6 0.6 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 CCF35573.1 - 5.5e-10 39.2 1.2 3.9e-09 36.4 1.2 2.0 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCF35573.1 - 1.5e-07 31.0 0.1 2.1e-06 27.2 0.1 2.4 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCF35573.1 - 1.5e-07 31.5 2.9 6.3e-07 29.5 0.8 2.8 2 1 1 3 3 3 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 CCF35573.1 - 3.2e-06 26.6 0.6 6.4e-06 25.7 0.6 1.4 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 CCF35573.1 - 9.5e-06 25.1 0.0 0.097 11.9 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CCF35573.1 - 0.00013 20.8 4.5 0.011 14.5 0.5 3.3 3 0 0 3 3 3 1 HI0933-like protein Amino_oxidase PF01593.24 CCF35573.1 - 0.00065 19.1 0.9 0.26 10.5 0.2 3.0 3 0 0 3 3 3 2 Flavin containing amine oxidoreductase Thi4 PF01946.17 CCF35573.1 - 0.00078 18.7 1.9 0.062 12.5 0.9 2.5 2 0 0 2 2 2 1 Thi4 family Pyr_redox PF00070.27 CCF35573.1 - 0.013 16.1 2.3 2.1 9.0 0.5 2.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CCF35573.1 - 0.013 14.6 4.5 0.17 11.0 1.5 2.3 2 0 0 2 2 2 0 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 CCF35573.1 - 0.04 13.2 0.8 0.076 12.3 0.8 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Pkinase PF00069.25 CCF35574.1 - 1.4e-53 181.9 0.0 2e-53 181.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF35574.1 - 1.2e-20 73.9 0.1 2.4e-20 72.9 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 CCF35574.1 - 0.028 14.3 0.0 0.062 13.2 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family Choline_kinase PF01633.20 CCF35574.1 - 0.059 13.0 0.4 0.13 11.8 0.4 1.6 1 0 0 1 1 1 0 Choline/ethanolamine kinase Vmethyltransf_C PF08456.10 CCF35574.1 - 0.16 11.5 0.0 0.34 10.4 0.0 1.5 1 1 0 1 1 1 0 Viral methyltransferase C-terminal ABC2_membrane PF01061.24 CCF35575.1 - 3.8e-37 127.7 22.3 5.7e-37 127.2 22.3 1.3 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 CCF35575.1 - 1.2e-06 29.1 0.0 1.9e-06 28.4 0.0 1.2 1 0 0 1 1 1 1 ABC transporter PDR_CDR PF06422.12 CCF35575.1 - 0.0042 16.9 0.0 0.0042 16.9 0.0 2.9 3 1 0 3 3 3 1 CDR ABC transporter SMC_N PF02463.19 CCF35575.1 - 0.073 12.5 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain ABC2_membrane_3 PF12698.7 CCF35575.1 - 9.3 5.3 14.9 17 4.4 14.8 1.4 1 1 0 1 1 1 0 ABC-2 family transporter protein DHquinase_II PF01220.19 CCF35576.1 - 2.9e-61 205.2 0.3 3.3e-61 205.0 0.3 1.0 1 0 0 1 1 1 1 Dehydroquinase class II ABC_tran PF00005.27 CCF35577.1 - 1.4e-31 109.8 0.0 2.3e-31 109.1 0.0 1.3 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 CCF35577.1 - 7.3e-29 101.3 9.2 1.2e-28 100.5 9.2 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 CCF35577.1 - 5.7e-05 22.7 0.0 0.0021 17.5 0.0 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 CCF35577.1 - 0.015 15.4 0.1 0.036 14.1 0.1 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_16 PF13191.6 CCF35577.1 - 0.02 15.3 0.3 0.042 14.2 0.3 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 CCF35577.1 - 0.12 12.7 0.2 0.95 9.7 0.2 2.4 1 1 0 1 1 1 0 AAA domain Gpi1 PF05024.15 CCF35577.1 - 0.19 11.8 3.0 0.16 12.1 0.2 2.0 2 0 0 2 2 2 0 N-acetylglucosaminyl transferase component (Gpi1) EF-hand_8 PF13833.6 CCF35578.1 - 0.029 14.2 0.0 0.25 11.2 0.0 2.3 2 0 0 2 2 2 0 EF-hand domain pair IF4E PF01652.18 CCF35579.1 - 3.1e-38 131.1 0.5 4e-38 130.7 0.5 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Nitroreductase PF00881.24 CCF35583.1 - 0.023 14.8 0.1 1.6 8.8 0.0 2.4 2 0 0 2 2 2 0 Nitroreductase family HycH PF07450.11 CCF35583.1 - 0.12 12.7 0.0 0.28 11.6 0.0 1.6 1 0 0 1 1 1 0 Formate hydrogenlyase maturation protein HycH NACHT PF05729.12 CCF35584.1 - 5.3e-19 68.8 0.0 9.4e-19 67.9 0.0 1.4 1 0 0 1 1 1 1 NACHT domain NB-ARC PF00931.22 CCF35584.1 - 3.3e-05 23.2 0.0 0.00012 21.3 0.0 1.8 1 1 0 1 1 1 1 NB-ARC domain AAA_22 PF13401.6 CCF35584.1 - 0.00018 21.8 0.6 0.002 18.4 0.6 2.3 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CCF35584.1 - 0.00091 19.6 0.7 0.045 14.1 0.7 2.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.6 CCF35584.1 - 0.034 14.2 0.0 0.094 12.7 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 CCF35584.1 - 0.055 13.2 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 CCF35584.1 - 0.06 13.3 0.1 0.12 12.3 0.1 1.4 1 0 0 1 1 1 0 NTPase RTP1_C2 PF10304.9 CCF35584.1 - 0.12 12.1 0.6 0.52 10.0 0.1 2.3 2 0 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 2 ABC_tran PF00005.27 CCF35584.1 - 0.18 12.4 0.0 0.38 11.3 0.0 1.5 1 0 0 1 1 1 0 ABC transporter TsaE PF02367.17 CCF35584.1 - 0.19 11.7 0.0 0.81 9.7 0.0 1.9 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE zf-C3HC4_2 PF13923.6 CCF35585.1 - 8.1e-11 41.6 13.2 8.1e-11 41.6 13.2 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CCF35585.1 - 3.7e-07 29.9 12.8 3.7e-07 29.9 12.8 2.9 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CCF35585.1 - 5.6e-07 29.3 9.6 5.6e-07 29.3 9.6 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CCF35585.1 - 1.8e-06 27.9 10.2 1.8e-06 27.9 10.2 2.6 3 0 0 3 3 3 1 RING-type zinc-finger zf-RING_5 PF14634.6 CCF35585.1 - 4.4e-06 26.6 12.3 4.4e-06 26.6 12.3 2.4 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.6 CCF35585.1 - 7.4e-06 26.2 18.1 1.1e-05 25.7 12.2 2.5 2 0 0 2 2 2 1 Ring finger domain SAP PF02037.27 CCF35585.1 - 2.4e-05 24.0 0.4 4.9e-05 23.0 0.4 1.6 1 0 0 1 1 1 1 SAP domain Prok-RING_4 PF14447.6 CCF35585.1 - 8.7e-05 22.3 14.4 0.0022 17.8 10.3 2.3 2 0 0 2 2 2 2 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 CCF35585.1 - 9.3e-05 22.5 11.9 9.3e-05 22.5 11.9 2.4 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.6 CCF35585.1 - 0.00015 21.6 4.6 0.00015 21.6 4.6 1.9 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-rbx1 PF12678.7 CCF35585.1 - 0.00068 19.9 6.1 0.00068 19.9 6.1 2.4 2 0 0 2 2 2 1 RING-H2 zinc finger domain U-box PF04564.15 CCF35585.1 - 0.012 15.8 0.0 0.028 14.6 0.0 1.6 1 0 0 1 1 1 0 U-box domain YDG PF18657.1 CCF35585.1 - 0.18 12.0 0.0 0.39 11.0 0.0 1.6 1 0 0 1 1 1 0 YDG domain Mob_synth_C PF06463.13 CCF35585.1 - 0.2 11.6 3.4 0.45 10.5 3.4 1.5 1 0 0 1 1 1 0 Molybdenum Cofactor Synthesis C zf-RING_10 PF16685.5 CCF35585.1 - 0.33 11.1 11.5 0.041 14.0 6.5 2.0 2 0 0 2 2 2 0 zinc RING finger of MSL2 zf-Di19 PF05605.12 CCF35585.1 - 6.2 7.2 9.2 0.89 9.9 0.1 2.9 2 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-RING_4 PF14570.6 CCF35585.1 - 8.5 6.3 15.4 0.17 11.7 6.5 2.5 2 1 0 2 2 2 0 RING/Ubox like zinc-binding domain CDC27 PF09507.10 CCF35586.1 - 8.7e-86 289.0 27.4 3.7e-85 286.9 27.4 1.7 1 1 0 1 1 1 1 DNA polymerase subunit Cdc27 Glyco_hydro_125 PF06824.11 CCF35587.1 - 1.1e-179 597.7 0.0 1.3e-179 597.5 0.0 1.0 1 0 0 1 1 1 1 Metal-independent alpha-mannosidase (GH125) Aminotran_1_2 PF00155.21 CCF35588.1 - 1e-14 54.5 0.0 1.5e-14 54.0 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 CCF35588.1 - 4.3e-06 25.8 0.0 0.032 13.0 0.0 2.1 2 0 0 2 2 2 2 Alanine-glyoxylate amino-transferase DUF5615 PF18480.1 CCF35588.1 - 0.11 12.2 0.0 0.31 10.8 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF5615) MOZ_SAS PF01853.18 CCF35589.1 - 1.2e-81 272.6 0.1 1.8e-81 272.0 0.1 1.3 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 CCF35589.1 - 1.3e-22 79.2 0.9 2.3e-22 78.3 0.9 1.5 1 0 0 1 1 1 1 MYST family zinc finger domain Tudor-knot PF11717.8 CCF35589.1 - 5.9e-17 61.3 0.0 2.2e-16 59.5 0.0 2.0 2 0 0 2 2 2 1 RNA binding activity-knot of a chromodomain Acetyltransf_7 PF13508.7 CCF35589.1 - 0.00018 21.9 0.0 0.00036 20.9 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CCF35589.1 - 0.0065 16.7 0.0 0.014 15.6 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Pox_Ag35 PF03286.14 CCF35589.1 - 0.41 10.4 5.0 0.78 9.5 5.0 1.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein RNase_T PF00929.24 CCF35590.1 - 2e-16 61.0 0.0 4.8e-16 59.7 0.0 1.7 1 1 0 1 1 1 1 Exonuclease DNA_pol_A_exo1 PF01612.20 CCF35590.1 - 0.00032 20.5 0.0 0.00081 19.1 0.0 1.6 1 1 0 1 1 1 1 3'-5' exonuclease CMAS PF02353.20 CCF35591.1 - 5.1e-71 239.2 0.0 9.1e-71 238.3 0.0 1.3 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_25 PF13649.6 CCF35591.1 - 9.4e-12 45.5 0.0 1.8e-11 44.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF35591.1 - 4.7e-11 43.2 0.0 8.8e-11 42.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF35591.1 - 2.9e-08 33.7 0.0 5.1e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF35591.1 - 4.1e-08 33.2 0.0 6.8e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF35591.1 - 1.1e-05 26.1 0.0 2.2e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 CCF35591.1 - 0.0016 18.2 0.0 0.0033 17.2 0.0 1.5 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_18 PF12847.7 CCF35591.1 - 0.015 15.3 0.0 0.025 14.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_3 PF01596.17 CCF35591.1 - 0.061 12.5 0.0 0.098 11.8 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase Methyltransf_16 PF10294.9 CCF35591.1 - 0.15 11.8 0.0 0.24 11.1 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase DUF938 PF06080.12 CCF35591.1 - 0.21 11.3 0.0 0.79 9.4 0.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF938) DAO PF01266.24 CCF35592.1 - 1.9e-11 44.1 3.1 2.5e-11 43.8 3.1 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CCF35592.1 - 0.98 9.7 3.5 2.6 8.3 3.5 1.8 1 1 0 1 1 1 0 NAD(P)-binding Rossmann-like domain IPK PF03770.16 CCF35593.1 - 5.5e-57 192.8 0.0 1.3e-56 191.7 0.0 1.6 2 0 0 2 2 2 1 Inositol polyphosphate kinase SCIMP PF15050.6 CCF35593.1 - 0.13 12.7 0.0 0.49 10.9 0.0 2.0 1 0 0 1 1 1 0 SCIMP protein MFS_1 PF07690.16 CCF35595.1 - 2.5e-35 122.1 59.9 1.2e-30 106.7 37.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily PNK3P PF08645.11 CCF35596.1 - 1e-20 74.0 0.0 1.4e-20 73.6 0.0 1.2 1 0 0 1 1 1 1 Polynucleotide kinase 3 phosphatase AAA_33 PF13671.6 CCF35596.1 - 0.00019 21.6 0.0 0.00027 21.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CCF35596.1 - 0.018 15.3 0.0 0.039 14.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 CCF35596.1 - 0.054 13.5 0.1 0.077 13.0 0.1 1.2 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE 6PF2K PF01591.18 CCF35596.1 - 0.074 12.4 0.1 0.11 11.8 0.1 1.2 1 0 0 1 1 1 0 6-phosphofructo-2-kinase AAA_17 PF13207.6 CCF35596.1 - 0.091 13.2 0.1 0.13 12.7 0.1 1.2 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 CCF35596.1 - 0.14 11.4 0.0 0.2 10.9 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin Ploopntkinase3 PF18751.1 CCF35596.1 - 0.19 11.6 0.3 0.35 10.8 0.0 1.5 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 MMR_HSR1 PF01926.23 CCF35596.1 - 0.19 11.8 0.0 0.36 10.9 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CCF35596.1 - 0.2 11.6 0.0 0.28 11.1 0.0 1.2 1 0 0 1 1 1 0 RsgA GTPase AAA_30 PF13604.6 CCF35596.1 - 0.21 11.3 0.1 0.33 10.6 0.1 1.2 1 0 0 1 1 1 0 AAA domain MFS_1 PF07690.16 CCF35597.1 - 4.8e-20 71.8 26.2 4.8e-20 71.8 26.2 2.1 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 CCF35597.1 - 2e-09 36.4 1.4 3.4e-09 35.7 1.4 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Pex19 PF04614.12 CCF35598.1 - 1e-73 248.1 14.7 1e-73 248.1 14.7 1.5 1 1 1 2 2 2 1 Pex19 protein family KIX_2 PF16987.5 CCF35598.1 - 0.033 14.2 0.6 0.033 14.2 0.6 2.3 2 0 0 2 2 2 0 KIX domain ABC_tran_Xtn PF12848.7 CCF35598.1 - 0.7 10.0 6.8 1.2 9.3 1.5 2.4 2 0 0 2 2 2 0 ABC transporter GET2 PF08690.10 CCF35598.1 - 1.5 8.4 19.2 0.094 12.4 11.5 2.4 1 1 1 2 2 2 0 GET complex subunit GET2 ABC1 PF03109.16 CCF35600.1 - 7.2e-32 110.1 0.0 1.5e-31 109.0 0.0 1.6 1 0 0 1 1 1 1 ABC1 family SAT PF16073.5 CCF35600.1 - 0.021 14.6 0.0 0.036 13.8 0.0 1.4 1 0 0 1 1 1 0 Starter unit:ACP transacylase in aflatoxin biosynthesis FAD_binding_4 PF01565.23 CCF35601.1 - 2.9e-23 82.2 3.4 5.9e-23 81.1 3.4 1.5 1 0 0 1 1 1 1 FAD binding domain DUF885 PF05960.11 CCF35602.1 - 3.9e-37 129.1 1.0 1.8e-36 126.9 1.0 1.8 1 1 0 1 1 1 1 Bacterial protein of unknown function (DUF885) FliS PF02561.14 CCF35602.1 - 0.0013 18.9 0.0 0.018 15.3 0.0 2.6 3 0 0 3 3 3 1 Flagellar protein FliS DUF4253 PF14062.6 CCF35602.1 - 0.0064 16.6 0.0 0.021 15.0 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4253) DnaB PF00772.21 CCF35602.1 - 0.089 12.9 0.1 0.2 11.8 0.1 1.5 1 0 0 1 1 1 0 DnaB-like helicase N terminal domain G_glu_transpept PF01019.21 CCF35603.1 - 4.5e-13 48.8 0.0 4.9e-13 48.7 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase ALG11_N PF15924.5 CCF35604.1 - 3.3e-85 285.4 0.4 9.3e-85 283.9 0.0 1.9 3 0 0 3 3 3 1 ALG11 mannosyltransferase N-terminus Glycos_transf_1 PF00534.20 CCF35604.1 - 8.4e-22 77.5 0.0 1.7e-21 76.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 CCF35604.1 - 1e-11 45.4 0.0 2.1e-11 44.4 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 CCF35604.1 - 0.0012 18.9 0.1 0.0019 18.2 0.1 1.4 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Metal_CEHH PF14455.6 CCF35604.1 - 0.15 11.6 0.0 0.62 9.6 0.0 1.8 2 0 0 2 2 2 0 Predicted metal binding domain 60KD_IMP PF02096.20 CCF35605.1 - 2e-08 34.3 0.2 2.9e-08 33.8 0.2 1.2 1 0 0 1 1 1 1 60Kd inner membrane protein Syntaxin_2 PF14523.6 CCF35606.1 - 2.1e-25 89.0 5.6 2.1e-25 89.0 5.6 2.6 2 1 0 2 2 2 1 Syntaxin-like protein SNARE PF05739.19 CCF35606.1 - 1.9e-14 53.4 1.2 1.9e-14 53.4 1.2 2.2 2 0 0 2 2 2 1 SNARE domain Syntaxin PF00804.25 CCF35606.1 - 0.0069 16.1 14.6 0.034 13.8 14.6 2.1 1 1 0 1 1 1 1 Syntaxin Synaptobrevin PF00957.21 CCF35606.1 - 0.015 15.0 2.4 0.016 15.0 0.6 2.0 2 0 0 2 2 2 0 Synaptobrevin DUF883 PF05957.13 CCF35606.1 - 0.041 14.5 12.6 0.29 11.7 0.1 3.3 2 1 2 4 4 4 0 Bacterial protein of unknown function (DUF883) MCPsignal PF00015.21 CCF35606.1 - 0.096 12.5 12.9 3.6 7.4 8.9 3.0 1 1 2 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF1664 PF07889.12 CCF35606.1 - 0.1 12.7 12.4 3.9 7.5 0.6 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) T2SSF PF00482.23 CCF35606.1 - 1.4 8.9 4.1 0.63 10.0 0.8 2.2 2 1 0 2 2 2 0 Type II secretion system (T2SS), protein F Occludin_ELL PF07303.13 CCF35606.1 - 6.3 7.6 7.8 1.3 9.8 0.9 2.9 2 2 2 4 4 4 0 Occludin homology domain Tannase PF07519.11 CCF35608.1 - 1.5e-120 403.3 1.3 1.9e-120 402.9 1.3 1.1 1 0 0 1 1 1 1 Tannase and feruloyl esterase Hydrolase_4 PF12146.8 CCF35608.1 - 0.0026 17.0 0.0 0.21 10.8 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CCF35608.1 - 0.013 15.1 0.1 0.08 12.6 0.1 2.0 1 1 0 1 1 1 0 alpha/beta hydrolase fold Ketoacyl-synt_C PF02801.22 CCF35610.1 - 7e-41 139.0 0.0 2.9e-40 137.0 0.1 2.0 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Acyl_transf_1 PF00698.21 CCF35610.1 - 9.8e-31 107.4 0.4 2.2e-30 106.2 0.4 1.5 1 0 0 1 1 1 1 Acyl transferase domain KAsynt_C_assoc PF16197.5 CCF35610.1 - 3e-16 59.8 0.0 5.7e-16 59.0 0.0 1.4 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension MFS_1 PF07690.16 CCF35611.1 - 6.3e-44 150.3 37.1 1.1e-43 149.6 37.1 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 CCF35611.1 - 1.5e-08 33.5 21.4 2.5e-08 32.8 21.4 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) FSH1 PF03959.13 CCF35612.1 - 1.2e-24 87.2 0.1 1.3e-23 83.8 0.1 2.4 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.16 CCF35612.1 - 0.03 14.1 0.9 0.17 11.7 0.0 2.2 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase ketoacyl-synt PF00109.26 CCF35613.1 - 1.1e-76 257.8 0.0 2.4e-76 256.7 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 CCF35613.1 - 6.5e-55 185.8 0.2 1.9e-54 184.3 0.2 1.9 1 0 0 1 1 1 1 KR domain PS-DH PF14765.6 CCF35613.1 - 1.3e-53 182.2 0.0 2.3e-53 181.4 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 CCF35613.1 - 1.5e-48 166.0 4.0 1.6e-48 165.9 1.9 2.1 2 0 0 2 2 2 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 CCF35613.1 - 1.1e-33 115.8 0.1 1.1e-33 115.8 0.1 2.4 3 0 0 3 3 3 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 CCF35613.1 - 1.9e-17 63.7 0.0 6.5e-17 62.0 0.0 2.0 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension adh_short PF00106.25 CCF35613.1 - 6.7e-10 38.7 0.6 1e-07 31.6 0.0 2.6 2 0 0 2 2 2 1 short chain dehydrogenase PP-binding PF00550.25 CCF35613.1 - 2.8e-07 30.8 0.1 1e-06 29.0 0.1 1.9 1 0 0 1 1 1 1 Phosphopantetheine attachment site Thiolase_N PF00108.23 CCF35613.1 - 2e-06 27.4 0.7 1.6e-05 24.4 0.0 2.4 2 0 0 2 2 2 1 Thiolase, N-terminal domain adh_short_C2 PF13561.6 CCF35613.1 - 5.6e-06 26.1 0.2 4.2e-05 23.2 0.0 2.2 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase ADH_zinc_N PF00107.26 CCF35613.1 - 8.3e-05 22.6 0.0 0.00026 21.0 0.0 1.9 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCF35613.1 - 0.00012 23.1 0.0 0.00041 21.4 0.0 2.0 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ACP_syn_III PF08545.10 CCF35613.1 - 0.0025 17.7 0.1 0.0083 16.0 0.1 2.0 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III TetR_C_30 PF17939.1 CCF35613.1 - 0.14 12.4 0.3 4.2 7.6 0.2 3.2 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain AP_endonuc_2 PF01261.24 CCF35615.1 - 8.6e-06 25.3 0.0 3.1e-05 23.5 0.0 1.9 1 1 0 1 1 1 1 Xylose isomerase-like TIM barrel Peptidase_M74 PF03411.13 CCF35615.1 - 0.17 11.4 0.0 0.23 11.0 0.0 1.2 1 0 0 1 1 1 0 Penicillin-insensitive murein endopeptidase RTA1 PF04479.13 CCF35616.1 - 2.3e-51 174.3 6.3 3e-51 174.0 6.3 1.1 1 0 0 1 1 1 1 RTA1 like protein MIG-14_Wnt-bd PF06664.12 CCF35616.1 - 0.084 12.1 1.9 0.14 11.4 1.9 1.4 1 1 0 1 1 1 0 Wnt-binding factor required for Wnt secretion Renin_r PF07850.14 CCF35616.1 - 0.16 12.6 0.2 0.56 10.8 0.2 1.9 1 0 0 1 1 1 0 Renin receptor-like protein Ion_trans PF00520.31 CCF35617.1 - 1e-10 41.3 22.9 2.1e-10 40.3 22.9 1.5 1 0 0 1 1 1 1 Ion transport protein COesterase PF00135.28 CCF35618.1 - 4.8e-31 108.2 0.0 5.9e-31 107.9 0.0 1.2 1 0 0 1 1 1 1 Carboxylesterase family IKI3 PF04762.12 CCF35620.1 - 6.5e-12 44.3 0.0 7.1e-12 44.2 0.0 1.0 1 0 0 1 1 1 1 IKI3 family DUF3984 PF13136.6 CCF35621.1 - 3.7e-65 220.5 24.3 3.1e-64 217.5 24.3 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF3984) WD40 PF00400.32 CCF35623.1 - 0.3 12.0 1.5 0.77 10.7 0.1 2.1 2 1 0 2 2 2 0 WD domain, G-beta repeat tRNA-synt_His PF13393.6 CCF35624.1 - 3.3e-40 138.3 0.0 8.7e-34 117.2 0.0 2.1 2 0 0 2 2 2 2 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 CCF35624.1 - 1.4e-11 44.4 0.0 2.6e-11 43.5 0.0 1.4 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 CCF35624.1 - 0.00026 21.0 0.0 0.0008 19.4 0.0 1.8 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon2 PF12745.7 CCF35624.1 - 0.024 14.1 0.1 0.046 13.2 0.0 1.5 2 0 0 2 2 2 0 Anticodon binding domain of tRNAs tRNA-synt_2 PF00152.20 CCF35624.1 - 0.066 12.3 0.0 0.17 10.9 0.0 1.7 1 1 0 1 1 1 0 tRNA synthetases class II (D, K and N) Tmemb_14 PF03647.13 CCF35625.1 - 7.7e-19 68.2 4.9 3e-18 66.3 4.9 1.7 1 1 0 1 1 1 1 Transmembrane proteins 14C Gram_pos_anchor PF00746.21 CCF35625.1 - 0.15 12.0 0.1 0.15 12.0 0.1 3.6 5 0 0 5 5 5 0 LPXTG cell wall anchor motif EBP PF05241.12 CCF35626.1 - 3.7e-74 248.0 7.1 4.2e-74 247.8 7.1 1.0 1 0 0 1 1 1 1 Emopamil binding protein TMEM208_SND2 PF05620.11 CCF35626.1 - 0.26 11.0 8.7 0.26 11.1 2.1 2.3 2 0 0 2 2 2 0 SRP-independent targeting protein 2/TMEM208 MFS_1 PF07690.16 CCF35627.1 - 7.7e-26 90.8 20.1 1.1e-25 90.4 20.1 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_3 PF05977.13 CCF35627.1 - 0.016 13.7 2.0 0.035 12.5 2.0 1.5 1 1 0 1 1 1 0 Transmembrane secretion effector Sugar_tr PF00083.24 CCF35627.1 - 0.28 10.0 14.3 0.0086 15.0 7.7 1.7 2 1 0 2 2 2 0 Sugar (and other) transporter CDH-cyt PF16010.5 CCF35628.1 - 1.6e-20 73.6 0.0 4.5e-20 72.1 0.0 1.7 2 0 0 2 2 2 1 Cytochrome domain of cellobiose dehydrogenase Cytochrom_B561 PF03188.16 CCF35628.1 - 2.7e-08 34.0 12.1 5.5e-08 33.0 12.1 1.5 1 0 0 1 1 1 1 Eukaryotic cytochrome b561 DUF2427 PF10348.9 CCF35628.1 - 0.00034 20.4 1.1 0.00034 20.4 1.1 2.4 2 1 0 2 2 2 1 Domain of unknown function (DUF2427) DUF4079 PF13301.6 CCF35628.1 - 0.037 14.2 14.5 0.083 13.0 12.0 2.5 1 1 0 2 2 2 0 Protein of unknown function (DUF4079) DUF4532 PF15046.6 CCF35628.1 - 0.078 12.2 0.1 0.12 11.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4532) DUF2157 PF09925.9 CCF35628.1 - 0.76 9.6 12.1 5 6.9 1.3 2.2 1 1 1 2 2 2 0 Predicted membrane protein (DUF2157) DUF3309 PF11752.8 CCF35628.1 - 1.1 9.3 7.9 0.13 12.3 2.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3309) DUF2207 PF09972.9 CCF35628.1 - 1.2 7.8 11.6 2 7.1 0.6 2.6 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) DUF4231 PF14015.6 CCF35628.1 - 1.3 9.5 7.3 2.7 8.5 0.4 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF4231) NAD_binding_5 PF07994.12 CCF35629.1 - 1.2e-12 47.8 0.0 1.4e-12 47.7 0.0 1.0 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Pectate_lyase PF03211.13 CCF35630.1 - 8.6e-79 263.8 8.4 1.1e-78 263.5 8.4 1.1 1 0 0 1 1 1 1 Pectate lyase IBR PF01485.21 CCF35631.1 - 4e-12 46.2 28.3 4e-06 26.9 3.3 3.6 3 0 0 3 3 3 2 IBR domain, a half RING-finger domain zf-RING_UBOX PF13445.6 CCF35631.1 - 5.7e-08 32.7 3.8 5.7e-08 32.7 3.8 3.5 3 1 0 3 3 3 1 RING-type zinc-finger zf-C3HC4 PF00097.25 CCF35631.1 - 4.3e-06 26.5 3.9 4.3e-06 26.5 3.9 3.6 3 2 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CCF35631.1 - 8.7e-06 25.5 3.5 8.7e-06 25.5 3.5 4.3 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CCF35631.1 - 0.00017 21.9 2.0 0.00017 21.9 2.0 3.5 3 1 1 4 4 4 1 Ring finger domain zf-C3HC4_2 PF13923.6 CCF35631.1 - 0.00048 19.9 3.7 0.00048 19.9 3.7 4.3 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 CCF35631.1 - 0.00058 20.0 4.2 0.00058 20.0 4.2 3.6 3 1 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 CCF35631.1 - 0.0068 16.3 2.9 0.0068 16.3 2.9 3.5 3 1 0 3 3 3 1 zinc-RING finger domain Prok-RING_4 PF14447.6 CCF35631.1 - 0.0076 16.1 3.2 0.0076 16.1 3.2 4.4 3 1 1 4 4 4 1 Prokaryotic RING finger family 4 FAD_binding_4 PF01565.23 CCF35632.1 - 1.8e-22 79.6 1.1 3.5e-22 78.6 0.8 1.7 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.12 CCF35632.1 - 0.013 15.6 0.0 0.031 14.4 0.0 1.6 1 0 0 1 1 1 0 Berberine and berberine like COQ7 PF03232.13 CCF35633.1 - 0.028 14.2 0.1 0.033 14.0 0.1 1.2 1 0 0 1 1 1 0 Ubiquinone biosynthesis protein COQ7 PI3K_1B_p101 PF10486.9 CCF35633.1 - 0.36 8.6 6.1 0.4 8.4 6.1 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Neur_chan_memb PF02932.16 CCF35633.1 - 0.41 10.7 1.9 0.46 10.5 1.9 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region UCR_Fe-S_N PF10399.9 CCF35633.1 - 1.4 8.3 4.5 12 5.3 2.4 2.4 2 0 0 2 2 2 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal ATP11 PF06644.11 CCF35633.1 - 3.2 7.5 9.0 3.9 7.2 9.0 1.1 1 0 0 1 1 1 0 ATP11 protein Presenilin PF01080.17 CCF35633.1 - 3.9 6.1 10.0 4.4 5.9 10.0 1.1 1 0 0 1 1 1 0 Presenilin CysA_C_terminal PF17850.1 CCF35634.1 - 0.14 12.7 0.0 6.9 7.3 0.0 2.1 2 0 0 2 2 2 0 CysA C-terminal regulatory domain Dynein_light PF01221.18 CCF35635.1 - 2.7e-39 133.3 1.2 3.1e-39 133.2 1.2 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 SGTA_dimer PF16546.5 CCF35635.1 - 0.076 12.8 0.5 0.11 12.3 0.5 1.2 1 0 0 1 1 1 0 Homodimerisation domain of SGTA RRM_1 PF00076.22 CCF35636.1 - 1.4e-76 252.3 1.2 1.9e-18 66.1 0.0 5.4 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CCF35636.1 - 1e-08 34.9 0.0 0.023 14.5 0.0 5.0 5 0 0 5 5 5 2 Occluded RNA-recognition motif RRM_7 PF16367.5 CCF35636.1 - 1e-07 31.9 0.1 3.5 7.8 0.0 5.0 5 0 0 5 5 5 3 RNA recognition motif Limkain-b1 PF11608.8 CCF35636.1 - 1.4e-05 25.1 0.2 4.3 7.5 0.0 5.5 6 0 0 6 6 6 2 Limkain b1 Smg4_UPF3 PF03467.15 CCF35636.1 - 5.4e-05 23.3 3.7 0.0024 17.9 0.9 3.6 3 2 0 3 3 3 1 Smg-4/UPF3 family Nup35_RRM_2 PF14605.6 CCF35636.1 - 0.00012 21.9 0.0 2.9 8.0 0.0 3.8 4 0 0 4 4 4 2 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 CCF35636.1 - 0.00059 19.8 0.4 3.6 7.7 0.0 5.0 4 1 1 5 5 5 1 RNA binding motif RRM_Rrp7 PF17799.1 CCF35636.1 - 0.00084 19.2 0.0 14 5.4 0.0 4.1 4 0 0 4 4 4 1 Rrp7 RRM-like N-terminal domain RRM_2 PF04059.12 CCF35636.1 - 0.029 14.6 0.0 2.1 8.6 0.0 3.3 3 0 0 3 3 3 0 RNA recognition motif 2 PHM7_cyt PF14703.6 CCF35636.1 - 0.086 13.1 5.4 10 6.3 0.0 5.3 5 2 1 6 6 6 0 Cytosolic domain of 10TM putative phosphate transporter Peptidase_C26 PF07722.13 CCF35636.1 - 0.13 12.0 0.0 0.25 11.1 0.0 1.4 1 0 0 1 1 1 0 Peptidase C26 SRP54 PF00448.22 CCF35637.1 - 3.2e-76 255.3 2.6 5.7e-76 254.5 1.3 1.9 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 CCF35637.1 - 3e-30 104.8 6.1 3e-30 104.8 6.1 3.1 3 1 1 4 4 3 1 Signal peptide binding domain SRP54_N PF02881.19 CCF35637.1 - 6e-21 74.4 0.5 1.8e-20 72.9 0.5 1.9 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain cobW PF02492.19 CCF35637.1 - 1.6e-06 27.8 1.0 1e-05 25.2 0.9 2.3 2 1 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.6 CCF35637.1 - 2.4e-06 27.8 0.0 6.4e-06 26.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 CCF35637.1 - 7e-06 26.5 0.1 2.8e-05 24.6 0.1 2.1 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CCF35637.1 - 0.00014 22.3 0.0 0.00028 21.3 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain MeaB PF03308.16 CCF35637.1 - 0.00092 18.3 0.5 0.0069 15.4 0.5 2.3 1 1 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Zeta_toxin PF06414.12 CCF35637.1 - 0.0011 18.2 0.0 0.0025 17.1 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin APS_kinase PF01583.20 CCF35637.1 - 0.002 18.0 0.0 0.0043 16.9 0.0 1.6 1 0 0 1 1 1 1 Adenylylsulphate kinase MMR_HSR1 PF01926.23 CCF35637.1 - 0.002 18.2 0.3 0.049 13.7 0.1 2.9 2 1 0 2 2 2 1 50S ribosome-binding GTPase Thymidylate_kin PF02223.17 CCF35637.1 - 0.0034 17.1 0.3 0.014 15.1 0.0 2.1 2 0 0 2 2 2 1 Thymidylate kinase SRPRB PF09439.10 CCF35637.1 - 0.0036 16.8 0.6 2 7.8 0.8 3.2 2 1 0 2 2 2 1 Signal recognition particle receptor beta subunit AAA_30 PF13604.6 CCF35637.1 - 0.0037 17.0 0.1 0.0037 17.0 0.1 2.1 2 1 0 2 2 2 1 AAA domain CbiA PF01656.23 CCF35637.1 - 0.0047 17.0 0.0 0.013 15.6 0.0 1.8 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_18 PF13238.6 CCF35637.1 - 0.005 17.4 0.0 0.012 16.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CCF35637.1 - 0.005 17.1 0.0 0.014 15.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 CCF35637.1 - 0.006 16.6 0.4 0.015 15.3 0.4 1.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit ATP_bind_1 PF03029.17 CCF35637.1 - 0.0082 15.9 0.3 0.032 14.0 0.1 2.1 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein MobB PF03205.14 CCF35637.1 - 0.014 15.3 0.3 0.044 13.7 0.0 2.0 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_28 PF13521.6 CCF35637.1 - 0.015 15.6 0.0 0.029 14.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 CCF35637.1 - 0.033 14.5 0.1 0.081 13.3 0.1 1.7 1 0 0 1 1 1 0 AAA domain 6PF2K PF01591.18 CCF35637.1 - 0.065 12.5 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 6-phosphofructo-2-kinase Arf PF00025.21 CCF35637.1 - 0.067 12.6 0.1 0.32 10.4 0.0 2.1 3 0 0 3 3 3 0 ADP-ribosylation factor family AAA PF00004.29 CCF35637.1 - 0.11 12.9 0.4 0.44 11.0 0.4 2.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_31 PF13614.6 CCF35637.1 - 0.12 12.3 0.0 0.32 10.9 0.0 1.7 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CCF35637.1 - 0.13 12.8 0.8 0.37 11.3 0.0 2.1 2 1 0 2 2 2 0 ABC transporter SKA2 PF16740.5 CCF35637.1 - 0.83 9.5 3.1 26 4.7 1.5 2.6 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 Peptidase_M14 PF00246.24 CCF35638.1 - 7.2e-23 81.8 0.4 9.9e-23 81.4 0.4 1.2 1 0 0 1 1 1 1 Zinc carboxypeptidase p450 PF00067.22 CCF35639.1 - 4.4e-52 177.4 0.0 1e-51 176.2 0.0 1.5 1 1 0 1 1 1 1 Cytochrome P450 UL2 PF08196.11 CCF35640.1 - 2.8 8.0 4.8 2.7 8.0 0.2 2.7 3 0 0 3 3 3 0 UL2 protein PH PF00169.29 CCF35641.1 - 0.00015 22.3 0.0 0.00054 20.4 0.0 2.0 1 1 0 1 1 1 1 PH domain SAM_2 PF07647.17 CCF35641.1 - 0.0053 16.8 0.0 0.012 15.7 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) CDK2AP PF09806.9 CCF35641.1 - 0.61 10.1 2.3 1.2 9.1 2.3 1.4 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein Pkinase PF00069.25 CCF35643.1 - 4.3e-32 111.5 0.0 2.1e-22 79.7 0.0 2.7 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCF35643.1 - 2.2e-24 86.2 0.0 4.1e-24 85.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase HALZ PF02183.18 CCF35643.1 - 0.033 14.4 0.2 0.033 14.4 0.2 2.1 3 0 0 3 3 3 0 Homeobox associated leucine zipper Tmemb_cc2 PF10267.9 CCF35643.1 - 0.039 13.1 4.8 0.063 12.4 4.8 1.3 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein FhuF PF06276.12 CCF35643.1 - 0.081 13.3 0.1 0.8 10.1 0.0 2.4 2 0 0 2 2 2 0 Ferric iron reductase FhuF-like transporter Atg14 PF10186.9 CCF35643.1 - 0.15 11.1 8.1 0.25 10.4 8.1 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 GBP_C PF02841.14 CCF35643.1 - 0.28 10.5 7.6 0.44 9.9 7.6 1.2 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain ADIP PF11559.8 CCF35643.1 - 0.3 11.2 16.8 0.33 11.0 11.8 2.4 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding PRKG1_interact PF15898.5 CCF35643.1 - 1.2 10.1 11.7 3.3 8.7 11.7 1.7 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain YabA PF06156.13 CCF35643.1 - 1.3 9.7 4.6 5.1 7.8 4.6 1.9 1 1 0 1 1 1 0 Initiation control protein YabA DivIC PF04977.15 CCF35643.1 - 2.1 8.2 11.4 0.083 12.7 0.5 2.4 1 1 1 2 2 2 0 Septum formation initiator DUF3328 PF11807.8 CCF35644.1 - 1.2e-47 162.6 0.2 1.4e-47 162.3 0.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Glyco_hydro_97 PF10566.9 CCF35644.1 - 0.081 12.2 0.1 0.11 11.7 0.1 1.2 1 0 0 1 1 1 0 Glycoside hydrolase 97 Tox-PL-2 PF15643.6 CCF35644.1 - 0.14 12.3 0.0 0.36 11.0 0.0 1.6 1 0 0 1 1 1 0 Papain fold toxin 2 Apidaecin PF00807.17 CCF35645.1 - 0.024 14.7 34.1 22 5.3 0.3 7.1 7 0 0 7 7 7 0 Apidaecin Trp_DMAT PF11991.8 CCF35646.1 - 6.8e-51 173.8 0.0 8.5e-51 173.5 0.0 1.0 1 0 0 1 1 1 1 Tryptophan dimethylallyltransferase MFS_1 PF07690.16 CCF35647.1 - 5.4e-19 68.3 41.3 7.5e-19 67.9 41.3 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily COesterase PF00135.28 CCF35648.1 - 1.5e-39 136.3 1.1 4.2e-31 108.4 0.2 2.0 1 1 1 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.13 CCF35648.1 - 3e-06 27.3 0.0 4.8e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Cellsynth_D PF03500.13 CCF35648.1 - 0.18 11.7 0.0 0.32 10.9 0.0 1.4 1 0 0 1 1 1 0 Cellulose synthase subunit D F-box-like PF12937.7 CCF35651.1 - 3.3e-06 26.9 0.4 6.8e-06 25.9 0.4 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCF35651.1 - 3.9e-06 26.6 0.2 1.1e-05 25.2 0.2 1.8 1 0 0 1 1 1 1 F-box domain DUF3450 PF11932.8 CCF35651.1 - 0.0035 16.7 0.7 0.0078 15.5 0.7 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) F-box-like_2 PF13013.6 CCF35651.1 - 0.045 13.7 0.0 0.12 12.4 0.0 1.8 1 0 0 1 1 1 0 F-box-like domain Leu_zip PF15294.6 CCF35651.1 - 0.074 12.6 0.1 0.15 11.5 0.1 1.4 1 0 0 1 1 1 0 Leucine zipper Rootletin PF15035.6 CCF35651.1 - 0.34 10.9 2.5 0.69 9.9 2.5 1.4 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion Atg14 PF10186.9 CCF35651.1 - 0.52 9.3 3.8 0.19 10.8 0.8 1.7 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 ATG16 PF08614.11 CCF35651.1 - 2.1 8.6 15.7 0.085 13.1 6.3 2.3 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) APG6_N PF17675.1 CCF35651.1 - 5.7 7.5 6.0 0.47 11.0 0.5 1.9 2 0 0 2 2 2 0 Apg6 coiled-coil region Baculo_PEP_C PF04513.12 CCF35651.1 - 6.7 6.7 6.4 0.64 10.1 1.1 1.9 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Spc7 PF08317.11 CCF35651.1 - 8.8 5.1 7.4 0.29 10.0 1.2 1.6 2 0 0 2 2 2 0 Spc7 kinetochore protein Cerato-platanin PF07249.12 CCF35652.1 - 0.00094 19.3 0.2 0.0024 18.0 0.0 1.7 2 0 0 2 2 2 1 Cerato-platanin Amidase PF01425.21 CCF35653.1 - 6.6e-55 186.9 0.3 6.7e-54 183.5 0.3 2.0 1 1 0 1 1 1 1 Amidase PUMA PF15826.5 CCF35653.1 - 0.061 13.5 2.2 0.37 10.9 0.1 2.2 2 0 0 2 2 2 0 Bcl-2-binding component 3, p53 upregulated modulator of apoptosis PRIMA1 PF16101.5 CCF35654.1 - 0.78 9.8 5.2 1.4 9.0 5.2 1.4 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 DEC-1_N PF04625.13 CCF35654.1 - 1.4 7.8 6.0 1.7 7.6 6.0 1.1 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region CAP_N PF01213.19 CCF35654.1 - 5.8 6.3 9.0 8 5.8 9.0 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal FAD-oxidase_C PF02913.19 CCF35655.1 - 2.4e-62 210.8 0.0 3.4e-62 210.3 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 CCF35655.1 - 3.5e-39 133.7 0.0 6.2e-39 132.9 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain ANF_receptor PF01094.28 CCF35655.1 - 0.046 12.8 0.0 0.07 12.2 0.0 1.2 1 0 0 1 1 1 0 Receptor family ligand binding region SepSecS PF05889.13 CCF35655.1 - 0.079 11.6 0.0 0.13 10.9 0.0 1.2 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS MFS_1 PF07690.16 CCF35657.1 - 3.3e-34 118.4 28.9 3.3e-34 118.4 28.9 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF2427 PF10348.9 CCF35657.1 - 1.2 9.0 6.5 2.3 8.0 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF2427) OPT PF03169.15 CCF35658.1 - 1.1e-95 321.6 25.2 1.4e-48 166.0 8.7 2.0 1 1 1 2 2 2 2 OPT oligopeptide transporter protein Fungal_trans_2 PF11951.8 CCF35659.1 - 1e-06 27.9 0.8 1.7e-06 27.1 0.8 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF35659.1 - 1.3e-06 28.4 7.7 3.1e-06 27.2 7.7 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AAA PF00004.29 CCF35661.1 - 1.6e-17 64.2 0.0 3.4e-17 63.1 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CCF35661.1 - 0.00036 21.0 0.0 0.0011 19.3 0.0 1.9 1 0 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.12 CCF35661.1 - 0.012 15.4 0.0 0.023 14.5 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 CCF35661.1 - 0.014 15.6 0.6 0.056 13.7 0.1 2.2 2 1 0 2 2 2 0 AAA domain AAA_5 PF07728.14 CCF35661.1 - 0.042 13.9 0.0 0.1 12.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 CCF35661.1 - 0.06 13.9 0.1 0.65 10.5 0.0 2.8 3 0 0 3 3 3 0 AAA domain AAA_33 PF13671.6 CCF35661.1 - 0.13 12.4 0.0 0.58 10.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain Vta1 PF04652.16 CCF35661.1 - 0.16 12.0 5.7 0.17 11.8 0.4 2.9 2 1 1 3 3 3 0 Vta1 like tRNA-synt_1g PF09334.11 CCF35666.1 - 1.6e-141 471.6 0.5 1.2e-139 465.4 0.5 2.1 1 1 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 CCF35666.1 - 2.2e-07 29.5 4.5 0.00077 17.8 0.0 4.0 5 0 0 5 5 5 2 tRNA synthetases class I (I, L, M and V) 3HCDH_N PF02737.18 CCF35666.1 - 2.6 7.9 8.1 5.1 6.9 8.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain WD40 PF00400.32 CCF35667.1 - 9.9e-09 35.7 2.3 0.24 12.3 0.0 6.4 5 1 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF35667.1 - 7.7e-07 29.3 0.0 0.39 11.0 0.0 4.3 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CCF35667.1 - 0.016 14.2 0.3 1.5 7.7 0.0 2.6 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 CCF35667.1 - 0.028 14.4 0.2 38 4.4 0.0 4.5 4 1 0 4 4 4 0 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 CCF35667.1 - 0.044 12.3 0.2 0.11 11.0 0.0 1.6 2 0 0 2 2 2 0 Cytochrome D1 heme domain Caps_synth PF05704.12 CCF35671.1 - 1.9e-12 47.2 0.0 3.2e-12 46.4 0.0 1.3 1 0 0 1 1 1 1 Capsular polysaccharide synthesis protein Gly_transf_sug PF04488.15 CCF35671.1 - 7.1e-06 26.6 0.0 1.3e-05 25.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Globin PF00042.22 CCF35672.1 - 5.4e-08 33.4 0.0 9.2e-08 32.6 0.0 1.4 1 0 0 1 1 1 1 Globin NAD_binding_1 PF00175.21 CCF35672.1 - 9.3e-06 26.3 0.0 2.7e-05 24.8 0.0 1.8 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 CCF35672.1 - 0.00096 19.5 0.0 0.0016 18.7 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 CCF35672.1 - 0.01 15.9 0.1 0.059 13.5 0.0 2.2 3 0 0 3 3 3 0 Ferric reductase NAD binding domain Protoglobin PF11563.8 CCF35672.1 - 0.053 13.4 0.0 0.13 12.1 0.0 1.7 1 1 0 1 1 1 0 Protoglobin NOA36 PF06524.12 CCF35673.1 - 1.3 8.3 4.9 2.3 7.5 4.9 1.3 1 0 0 1 1 1 0 NOA36 protein DUF4763 PF15960.5 CCF35674.1 - 0.013 14.8 0.6 0.013 14.8 0.6 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4763) DUF4726 PF15855.5 CCF35674.1 - 0.18 12.1 0.1 0.18 12.1 0.1 3.3 4 0 0 4 4 4 0 Domain of unknown function (DUF4726) DUF4407 PF14362.6 CCF35674.1 - 0.2 11.0 12.2 0.73 9.1 0.4 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) AIM5 PF17050.5 CCF35674.1 - 0.44 11.4 5.6 15 6.5 4.6 3.4 2 1 0 2 2 2 0 Altered inheritance of mitochondria 5 PRIMA1 PF16101.5 CCF35674.1 - 0.58 10.2 9.6 0.059 13.4 1.6 2.3 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 NeA_P2 PF12312.8 CCF35674.1 - 2.9 7.3 5.7 0.61 9.5 0.3 2.2 2 0 0 2 2 2 0 Nepovirus subgroup A polyprotein LMBR1 PF04791.16 CCF35674.1 - 3.6 6.4 3.9 6.1 5.6 3.9 1.4 1 0 0 1 1 1 0 LMBR1-like membrane protein E2F_CC-MB PF16421.5 CCF35674.1 - 6.1 7.3 9.5 1.3 9.4 0.1 3.3 3 1 0 3 3 3 0 E2F transcription factor CC-MB domain AA_permease PF00324.21 CCF35675.1 - 3.3e-44 151.3 10.5 4.3e-44 150.9 10.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CCF35675.1 - 3.3e-12 46.0 14.2 4.7e-12 45.5 14.2 1.2 1 0 0 1 1 1 1 Amino acid permease Vfa1 PF08432.10 CCF35676.1 - 2.6 8.4 7.6 3.3 8.0 7.6 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Zn_clus PF00172.18 CCF35677.1 - 9.5e-08 32.1 12.3 1.6e-07 31.3 12.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Herpes_capsid PF06112.11 CCF35677.1 - 0.093 12.8 3.4 0.2 11.7 3.4 1.6 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein SelP_N PF04592.14 CCF35677.1 - 0.29 10.5 8.3 0.51 9.7 8.3 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region CPSase_L_D2 PF02786.17 CCF35678.1 - 1.2e-67 227.5 2.3 3e-65 219.7 2.3 2.2 1 1 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 CCF35678.1 - 2.2e-25 89.3 0.0 4.6e-25 88.3 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 CCF35678.1 - 2.2e-23 82.4 0.0 2.5e-21 75.8 0.0 2.5 1 1 0 1 1 1 1 Biotin carboxylase C-terminal domain HMGL-like PF00682.19 CCF35678.1 - 1.5e-12 47.6 0.0 3.8e-12 46.3 0.0 1.7 1 1 0 1 1 1 1 HMGL-like Dala_Dala_lig_C PF07478.13 CCF35678.1 - 0.00067 19.2 0.0 0.0029 17.2 0.0 1.9 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.14 CCF35678.1 - 0.027 14.5 0.0 0.055 13.5 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp domain RimK PF08443.11 CCF35678.1 - 0.037 13.6 0.1 2.8 7.5 0.1 2.3 2 0 0 2 2 2 0 RimK-like ATP-grasp domain DUF2097 PF09870.9 CCF35678.1 - 0.068 13.4 3.9 8.1 6.7 0.0 3.0 3 0 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2097) ATP-grasp PF02222.22 CCF35678.1 - 0.074 12.6 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 ATP-grasp domain PI-PLC-X PF00388.19 CCF35680.1 - 2.4e-59 199.1 0.0 4.1e-59 198.3 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 CCF35680.1 - 4.2e-42 143.1 0.1 1e-41 141.9 0.1 1.7 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.30 CCF35680.1 - 8.1e-09 35.7 0.9 2.9e-08 34.0 0.1 2.3 2 0 0 2 2 2 1 C2 domain PH_12 PF16457.5 CCF35680.1 - 0.0001 22.9 0.4 0.0004 20.9 0.4 2.0 1 1 0 1 1 1 1 Pleckstrin homology domain EF-hand_6 PF13405.6 CCF35680.1 - 0.00018 21.2 1.7 1.2 9.3 0.1 4.3 4 0 0 4 4 4 2 EF-hand domain EF-hand_like PF09279.11 CCF35680.1 - 0.014 15.8 0.0 0.034 14.6 0.0 1.6 1 0 0 1 1 1 0 Phosphoinositide-specific phospholipase C, efhand-like EF-hand_7 PF13499.6 CCF35680.1 - 0.051 14.0 0.1 0.67 10.5 0.1 2.8 1 1 0 1 1 1 0 EF-hand domain pair PH PF00169.29 CCF35680.1 - 0.37 11.3 4.0 0.23 12.0 0.6 2.4 2 0 0 2 2 2 0 PH domain MFS_1 PF07690.16 CCF35681.1 - 3.9e-23 82.0 25.3 3.9e-23 82.0 25.3 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF35681.1 - 1.2e-07 30.9 3.9 1.2e-07 30.9 3.9 2.7 3 0 0 3 3 3 2 Sugar (and other) transporter Ima1_N PF09779.9 CCF35683.1 - 6.7e-22 78.8 1.1 1.4e-21 77.7 1.1 1.5 1 0 0 1 1 1 1 Ima1 N-terminal domain PAP2_3 PF14378.6 CCF35685.1 - 2.8e-24 85.9 12.0 2.8e-24 85.9 12.0 1.6 2 0 0 2 2 2 1 PAP2 superfamily PAP2 PF01569.21 CCF35685.1 - 3.2e-10 39.9 4.9 3.2e-10 39.9 4.9 2.3 1 1 1 2 2 2 1 PAP2 superfamily Ribosomal_S27e PF01667.17 CCF35686.1 - 0.34 10.6 7.5 0.25 11.1 3.5 2.0 1 1 1 2 2 2 0 Ribosomal protein S27 Fer4_6 PF12837.7 CCF35686.1 - 0.38 10.9 12.6 0.53 10.4 0.5 3.2 3 0 0 3 3 3 0 4Fe-4S binding domain Fer4 PF00037.27 CCF35686.1 - 0.79 9.6 0.1 0.79 9.6 0.1 2.7 3 0 0 3 3 3 0 4Fe-4S binding domain HypA PF01155.19 CCF35686.1 - 2.9 7.9 6.0 5.5 7.1 6.0 1.5 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Fer4_2 PF12797.7 CCF35686.1 - 3.4 8.0 18.1 1.9 8.7 10.8 3.2 1 1 1 2 2 2 0 4Fe-4S binding domain Fer4_10 PF13237.6 CCF35686.1 - 6.5 7.0 13.9 0.49 10.6 1.7 2.8 2 1 1 3 3 3 0 4Fe-4S dicluster domain c-SKI_SMAD_bind PF08782.10 CCF35686.1 - 7.1 6.9 7.3 1 9.6 3.0 1.7 1 1 1 2 2 2 0 c-SKI Smad4 binding domain Fer4_4 PF12800.7 CCF35686.1 - 8.1 7.2 16.4 15 6.4 11.1 3.0 2 1 0 2 2 2 0 4Fe-4S binding domain Pkinase PF00069.25 CCF35687.1 - 7.2e-70 235.4 0.0 8.9e-70 235.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF35687.1 - 5.4e-28 98.0 0.0 7.3e-28 97.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF35687.1 - 1.5e-07 31.0 0.0 2.1e-07 30.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 CCF35687.1 - 0.00011 21.1 0.1 0.00024 20.0 0.0 1.5 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 CCF35687.1 - 0.0005 20.1 0.1 0.0008 19.4 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 CCF35687.1 - 0.00086 18.7 0.0 0.0016 17.8 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family SAM_DrpA PF18255.1 CCF35687.1 - 0.046 14.0 0.0 0.074 13.3 0.0 1.3 1 0 0 1 1 1 0 DNA processing protein A sterile alpha motif domain PRTase_1 PF11202.8 CCF35688.1 - 0.084 12.1 0.6 0.089 12.0 0.6 1.0 1 0 0 1 1 1 0 Phosphoribosyl transferase (PRTase) adh_short PF00106.25 CCF35689.1 - 1.5e-21 76.8 0.0 3.4e-17 62.6 0.1 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCF35689.1 - 2.6e-08 33.7 0.0 1.7e-07 31.1 0.0 1.9 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF35689.1 - 2.7e-06 27.4 0.3 4.1e-06 26.8 0.3 1.2 1 0 0 1 1 1 1 KR domain Cutinase PF01083.22 CCF35690.1 - 3.2e-28 98.9 0.0 5.4e-28 98.2 0.0 1.3 1 0 0 1 1 1 1 Cutinase Jacalin PF01419.17 CCF35690.1 - 3e-06 27.2 0.9 1e-05 25.5 0.9 1.7 1 1 1 2 2 2 1 Jacalin-like lectin domain FSH1 PF03959.13 CCF35690.1 - 0.001 18.7 0.1 0.0033 17.1 0.0 1.7 2 0 0 2 2 2 1 Serine hydrolase (FSH1) VirJ PF06057.11 CCF35690.1 - 0.0073 16.2 0.0 0.015 15.2 0.0 1.5 1 0 0 1 1 1 1 Bacterial virulence protein (VirJ) Lipase_3 PF01764.25 CCF35690.1 - 0.014 15.2 0.0 0.023 14.5 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) PE-PPE PF08237.11 CCF35690.1 - 0.029 13.9 0.0 0.041 13.4 0.0 1.3 1 0 0 1 1 1 0 PE-PPE domain DUF3089 PF11288.8 CCF35690.1 - 0.077 12.5 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) adh_short PF00106.25 CCF35691.1 - 1.1e-09 38.0 0.0 1.3e-09 37.8 0.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF35691.1 - 3.1e-06 26.9 0.0 3.5e-06 26.8 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 CCF35691.1 - 0.0071 15.8 0.0 0.0071 15.8 0.0 1.0 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CCF35691.1 - 0.022 14.7 0.0 0.027 14.4 0.0 1.1 1 0 0 1 1 1 0 NAD(P)H-binding DUF1382 PF07131.11 CCF35691.1 - 0.03 14.3 0.0 0.039 14.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1382) Sacchrp_dh_NADP PF03435.18 CCF35691.1 - 0.062 13.6 0.0 0.081 13.2 0.0 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain TRAPPC9-Trs120 PF08626.11 CCF35692.1 - 0 1467.9 0.0 0 1467.7 0.0 1.0 1 0 0 1 1 1 1 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit Edc3_linker PF16598.5 CCF35692.1 - 0.26 12.0 0.8 0.77 10.5 0.8 1.8 1 0 0 1 1 1 0 Linker region of enhancer of mRNA-decapping protein 3 Glyco_hydro_63N PF16923.5 CCF35693.1 - 1.1e-80 271.0 0.1 1.2e-80 270.8 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 63 N-terminal domain ICMT PF04140.14 CCF35694.1 - 0.15 12.5 0.0 0.2 12.1 0.0 1.1 1 0 0 1 1 1 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family FF PF01846.19 CCF35695.1 - 1.3e-10 41.2 5.1 2.7e-08 33.9 0.5 3.3 3 0 0 3 3 3 2 FF domain WW PF00397.26 CCF35695.1 - 1.8e-08 34.3 2.0 1.8e-08 34.3 2.0 2.6 2 0 0 2 2 2 1 WW domain DUF5641 PF18701.1 CCF35695.1 - 2.8 8.1 5.3 0.95 9.7 1.8 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5641) PAP2 PF01569.21 CCF35696.1 - 5.6e-27 94.2 1.2 5.6e-27 94.2 1.2 2.1 2 0 0 2 2 2 1 PAP2 superfamily TM140 PF14985.6 CCF35696.1 - 0.032 13.8 0.2 0.089 12.3 0.0 1.8 2 0 0 2 2 2 0 TM140 protein family PAP2_3 PF14378.6 CCF35696.1 - 0.16 11.6 9.4 2.5 7.7 8.7 2.5 1 1 0 1 1 1 0 PAP2 superfamily Proteasome PF00227.26 CCF35697.1 - 1.3e-60 204.2 0.1 1.6e-60 203.8 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 CCF35697.1 - 2.8e-13 49.3 0.1 8.7e-13 47.7 0.1 1.9 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature DUF5624 PF18538.1 CCF35697.1 - 0.011 15.9 0.7 0.035 14.2 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF5624) Nitrate_red_gam PF02665.14 CCF35697.1 - 0.022 14.3 0.0 0.032 13.8 0.0 1.2 1 0 0 1 1 1 0 Nitrate reductase gamma subunit PHD PF00628.29 CCF35698.1 - 4.9e-10 39.1 8.5 1.1e-09 38.0 8.5 1.6 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 CCF35698.1 - 0.082 12.5 3.2 0.17 11.4 3.2 1.6 1 0 0 1 1 1 0 PHD-finger DUF4050 PF13259.6 CCF35698.1 - 2.8 8.2 13.6 0.93 9.8 9.7 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4050) TraH_2 PF06871.11 CCF35698.1 - 3.3 7.3 6.3 0.97 9.0 0.0 2.2 1 1 1 2 2 2 0 TraH_2 Tyosinase_C PF18132.1 CCF35699.1 - 2.3e-27 96.0 0.0 4.8e-27 95.0 0.0 1.5 1 0 0 1 1 1 1 Tyosinase C-terminal domain Tyrosinase PF00264.20 CCF35699.1 - 7.2e-19 69.0 2.8 1.2e-18 68.2 2.8 1.4 1 0 0 1 1 1 1 Common central domain of tyrosinase Methyltransf_2 PF00891.18 CCF35700.1 - 2.6e-22 79.2 0.0 3.9e-22 78.6 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_25 PF13649.6 CCF35700.1 - 0.00079 20.1 0.0 0.0033 18.1 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 CCF35700.1 - 0.0047 16.5 0.0 0.011 15.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase small domain PG_binding_1 PF01471.18 CCF35700.1 - 0.029 14.6 0.0 0.058 13.6 0.0 1.4 1 0 0 1 1 1 0 Putative peptidoglycan binding domain DNA_binding_1 PF01035.20 CCF35700.1 - 0.056 13.6 0.0 0.13 12.4 0.0 1.5 1 0 0 1 1 1 0 6-O-methylguanine DNA methyltransferase, DNA binding domain Methyltransf_16 PF10294.9 CCF35700.1 - 0.066 12.9 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase AflR PF08493.10 CCF35701.1 - 4.2e-10 39.6 4.9 1.4e-09 37.9 4.9 1.9 1 1 0 1 1 1 1 Aflatoxin regulatory protein adh_short PF00106.25 CCF35702.1 - 1.4e-44 151.9 0.1 1.7e-44 151.6 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF35702.1 - 4.8e-38 131.0 0.0 6.4e-38 130.6 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF35702.1 - 2.5e-12 47.1 0.2 3.2e-12 46.7 0.2 1.1 1 0 0 1 1 1 1 KR domain Eno-Rase_NADH_b PF12242.8 CCF35702.1 - 0.017 14.9 0.0 0.073 12.8 0.0 2.0 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase DEADboxA PF12343.8 CCF35703.1 - 0.064 13.8 3.5 0.087 13.4 3.5 1.1 1 0 0 1 1 1 0 Cold shock protein DEAD box A Mucin PF01456.17 CCF35703.1 - 0.76 9.8 16.2 0.75 9.8 16.2 1.1 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF2457 PF10446.9 CCF35703.1 - 2.9 6.9 7.5 3 6.9 7.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Fungal_trans PF04082.18 CCF35706.1 - 2.3e-22 79.3 0.0 3.7e-22 78.6 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Dioxygenase_C PF00775.21 CCF35707.1 - 3.7e-50 169.9 0.0 5.1e-50 169.4 0.0 1.2 1 0 0 1 1 1 1 Dioxygenase Dioxygenase_N PF04444.14 CCF35707.1 - 2.2e-28 97.9 0.1 3.2e-28 97.4 0.1 1.3 1 0 0 1 1 1 1 Catechol dioxygenase N terminus CarboxypepD_reg PF13620.6 CCF35707.1 - 4.6e-05 23.6 0.0 0.00041 20.6 0.0 2.2 2 0 0 2 2 2 1 Carboxypeptidase regulatory-like domain PlyB_C PF18684.1 CCF35707.1 - 0.043 13.5 0.2 1.8 8.3 0.0 2.8 2 1 0 2 2 2 0 Pleurotolysin B C-terminal domain YtkA PF13115.6 CCF35707.1 - 0.11 13.1 0.0 0.22 12.1 0.0 1.5 1 0 0 1 1 1 0 YtkA-like TBP-binding PF09247.11 CCF35707.1 - 0.23 11.7 1.1 0.84 9.9 0.2 2.3 2 0 0 2 2 2 0 TATA box-binding protein binding OPT PF03169.15 CCF35708.1 - 3e-180 600.9 51.0 3.4e-180 600.7 51.0 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein ketoacyl-synt PF00109.26 CCF35709.1 - 3.9e-62 210.1 4.0 1.3e-61 208.4 0.2 2.2 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 CCF35709.1 - 1.5e-36 125.0 2.0 6.7e-36 122.9 1.3 2.0 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.23 CCF35709.1 - 9.9e-07 28.4 0.8 6.3e-06 25.7 0.1 2.1 2 0 0 2 2 2 1 Thiolase, N-terminal domain KAsynt_C_assoc PF16197.5 CCF35709.1 - 0.06 13.8 0.2 0.13 12.7 0.2 1.6 1 0 0 1 1 1 0 Ketoacyl-synthetase C-terminal extension Thiolase_C PF02803.18 CCF35709.1 - 1.2 8.8 5.9 1.5 8.4 0.2 3.6 2 2 1 3 3 3 0 Thiolase, C-terminal domain Hepatitis_core PF00906.20 CCF35712.1 - 0.21 11.1 0.3 0.29 10.7 0.3 1.1 1 0 0 1 1 1 0 Hepatitis core antigen CorA PF01544.18 CCF35713.1 - 1.7e-15 57.1 4.8 1.6e-11 44.1 0.1 3.0 3 0 0 3 3 3 2 CorA-like Mg2+ transporter protein PAPS_reduct PF01507.19 CCF35714.1 - 4.1e-15 56.2 0.0 5.2e-07 29.9 0.0 2.2 1 1 1 2 2 2 2 Phosphoadenosine phosphosulfate reductase family ArsA_HSP20 PF17886.1 CCF35715.1 - 0.063 12.8 0.0 0.17 11.4 0.0 1.6 2 0 0 2 2 2 0 HSP20-like domain found in ArsA Cutinase PF01083.22 CCF35717.1 - 1e-48 165.6 0.5 1.3e-48 165.3 0.5 1.1 1 0 0 1 1 1 1 Cutinase DUF2974 PF11187.8 CCF35717.1 - 0.00055 19.6 0.0 0.00084 19.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2974) PE-PPE PF08237.11 CCF35717.1 - 0.00061 19.4 0.1 0.001 18.7 0.1 1.3 1 0 0 1 1 1 1 PE-PPE domain Lipase_3 PF01764.25 CCF35717.1 - 0.0027 17.6 0.0 0.0038 17.1 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_1 PF00561.20 CCF35717.1 - 0.005 16.5 0.0 0.0065 16.1 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 CCF35717.1 - 0.0084 16.0 0.4 0.019 14.8 0.4 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold VirJ PF06057.11 CCF35717.1 - 0.017 15.0 0.0 0.026 14.4 0.0 1.3 1 0 0 1 1 1 0 Bacterial virulence protein (VirJ) Chlorophyllase2 PF12740.7 CCF35717.1 - 0.02 13.8 0.1 0.027 13.4 0.1 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme Formyl_trans_N PF00551.19 CCF35718.1 - 1.2e-36 126.1 0.0 1.6e-36 125.7 0.0 1.2 1 0 0 1 1 1 1 Formyl transferase ACT PF01842.25 CCF35718.1 - 7.3e-08 32.1 0.0 1.9e-07 30.7 0.0 1.7 1 0 0 1 1 1 1 ACT domain ACT_6 PF13740.6 CCF35718.1 - 0.011 15.7 0.2 0.046 13.7 0.0 2.2 2 1 1 3 3 3 0 ACT domain ABC_membrane PF00664.23 CCF35719.1 - 4.7e-89 298.7 37.5 1e-45 156.5 16.1 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 CCF35719.1 - 6.2e-73 243.8 0.0 4.6e-35 121.1 0.0 2.4 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 CCF35719.1 - 3.6e-15 56.0 0.2 3.6e-05 23.3 0.0 4.2 3 1 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 CCF35719.1 - 1.1e-08 35.5 0.0 0.019 15.2 0.1 4.1 2 2 0 2 2 2 2 AAA domain ABC_ATPase PF09818.9 CCF35719.1 - 1.9e-08 33.5 0.2 0.015 14.2 0.0 3.5 4 0 0 4 4 4 2 Predicted ATPase of the ABC class AAA_29 PF13555.6 CCF35719.1 - 2.3e-08 33.7 0.2 0.0018 18.0 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 CCF35719.1 - 7.1e-08 33.0 0.4 0.0098 16.3 0.0 3.1 2 2 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 CCF35719.1 - 2.7e-07 30.7 0.0 0.014 15.3 0.0 2.7 2 0 0 2 2 2 2 RsgA GTPase AAA_21 PF13304.6 CCF35719.1 - 7.2e-07 29.3 0.2 0.29 10.9 0.0 4.2 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_25 PF13481.6 CCF35719.1 - 1e-05 25.2 0.0 0.17 11.4 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_15 PF13175.6 CCF35719.1 - 4.9e-05 23.2 0.0 0.11 12.2 0.0 2.2 2 0 0 2 2 2 2 AAA ATPase domain AAA_30 PF13604.6 CCF35719.1 - 0.00011 22.0 0.1 0.56 9.9 0.1 3.6 4 0 0 4 4 4 1 AAA domain AAA_23 PF13476.6 CCF35719.1 - 0.0002 21.9 0.0 0.16 12.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 CCF35719.1 - 0.00035 20.7 0.0 1.2 9.3 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 CCF35719.1 - 0.00036 20.5 0.1 1.9 8.5 0.0 3.4 4 0 0 4 4 3 2 AAA domain (dynein-related subfamily) Rad17 PF03215.15 CCF35719.1 - 0.00037 20.5 0.0 0.061 13.2 0.0 2.4 2 0 0 2 2 2 1 Rad17 P-loop domain Zeta_toxin PF06414.12 CCF35719.1 - 0.00071 18.9 0.0 0.092 12.0 0.0 2.9 3 0 0 3 3 3 1 Zeta toxin AAA PF00004.29 CCF35719.1 - 0.0011 19.4 5.0 0.19 12.2 0.4 4.3 2 2 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 CCF35719.1 - 0.0016 18.0 0.0 1.1 8.7 0.0 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region SbcCD_C PF13558.6 CCF35719.1 - 0.0024 18.1 2.0 6.1 7.1 0.1 4.3 3 2 0 3 3 2 0 Putative exonuclease SbcCD, C subunit ATP_bind_1 PF03029.17 CCF35719.1 - 0.0046 16.8 0.1 1.9 8.2 0.0 2.4 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein RNA_helicase PF00910.22 CCF35719.1 - 0.0081 16.5 0.1 1.3 9.5 0.0 2.9 3 0 0 3 3 2 1 RNA helicase MMR_HSR1 PF01926.23 CCF35719.1 - 0.0099 16.0 0.7 9.2 6.4 0.0 3.7 3 0 0 3 3 3 0 50S ribosome-binding GTPase AAA_18 PF13238.6 CCF35719.1 - 0.016 15.8 0.0 6.7 7.3 0.0 2.6 2 0 0 2 2 2 0 AAA domain G-alpha PF00503.20 CCF35719.1 - 0.02 14.0 0.0 3.5 6.7 0.0 2.2 2 0 0 2 2 2 0 G-protein alpha subunit PKHD_C PF18331.1 CCF35719.1 - 0.033 14.3 0.1 0.47 10.6 0.0 2.5 2 0 0 2 2 2 0 PKHD-type hydroxylase C-terminal domain AAA_28 PF13521.6 CCF35719.1 - 0.047 13.9 0.1 2.7 8.2 0.0 2.5 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 CCF35719.1 - 0.068 12.4 0.6 3.2 6.9 0.0 2.5 3 0 0 3 3 2 0 NB-ARC domain DUF3987 PF13148.6 CCF35719.1 - 0.082 11.9 0.0 3.8 6.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) AAA_24 PF13479.6 CCF35719.1 - 0.083 12.6 0.1 7.3 6.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 CCF35719.1 - 0.085 12.2 0.0 2 7.7 0.0 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI APS_kinase PF01583.20 CCF35719.1 - 0.16 11.9 0.0 4.6 7.1 0.0 2.6 2 0 0 2 2 2 0 Adenylylsulphate kinase E1-E2_ATPase PF00122.20 CCF35721.1 - 6e-35 120.4 2.8 2e-28 99.1 0.0 3.8 4 1 1 5 5 5 2 E1-E2 ATPase Cation_ATPase_C PF00689.21 CCF35721.1 - 1.8e-19 70.1 8.4 1.8e-19 70.1 8.4 2.6 2 1 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 CCF35721.1 - 6.3e-19 69.1 0.0 1.4e-17 64.7 0.0 2.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CCF35721.1 - 1.2e-16 60.5 0.0 2.4e-16 59.6 0.0 1.4 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 CCF35721.1 - 1.3e-15 56.8 1.4 3.7e-15 55.4 0.1 2.5 3 0 0 3 3 3 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 CCF35721.1 - 1.1e-05 25.3 1.4 1.3e-05 25.0 0.2 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF2463 PF09591.10 CCF35721.1 - 0.019 14.8 1.1 0.019 14.8 1.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2463) Aminotran_1_2 PF00155.21 CCF35722.1 - 6.2e-69 232.9 0.0 1.3e-68 231.9 0.0 1.5 1 1 0 1 1 1 1 Aminotransferase class I and II ISN1 PF06437.11 CCF35723.1 - 5e-125 417.6 0.0 5.5e-125 417.5 0.0 1.0 1 0 0 1 1 1 1 IMP-specific 5'-nucleotidase FlbD PF06289.11 CCF35723.1 - 0.075 12.6 0.0 0.16 11.6 0.0 1.5 1 0 0 1 1 1 0 Flagellar and Swarming motility proteins NIR_SIR PF01077.22 CCF35724.1 - 6.2e-57 191.6 0.0 8.2e-51 171.7 0.0 2.5 2 0 0 2 2 2 2 Nitrite and sulphite reductase 4Fe-4S domain NIR_SIR_ferr PF03460.17 CCF35724.1 - 2.6e-31 107.3 0.0 3.7e-15 55.5 0.0 2.6 2 0 0 2 2 2 2 Nitrite/Sulfite reductase ferredoxin-like half domain Flavodoxin_1 PF00258.25 CCF35724.1 - 2.2e-30 105.7 0.0 4.9e-30 104.6 0.0 1.6 1 0 0 1 1 1 1 Flavodoxin POR_N PF01855.19 CCF35724.1 - 1.7e-08 34.5 0.1 3.5e-08 33.5 0.1 1.5 1 0 0 1 1 1 1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg PFOR_II PF17147.4 CCF35724.1 - 4.7e-05 23.6 0.0 0.00012 22.3 0.0 1.7 1 0 0 1 1 1 1 Pyruvate:ferredoxin oxidoreductase core domain II RHH_7 PF16777.5 CCF35724.1 - 0.059 13.8 0.0 0.17 12.3 0.0 1.7 1 0 0 1 1 1 0 Transcriptional regulator, RHH-like, CopG AMP-binding PF00501.28 CCF35725.1 - 5e-107 358.1 0.0 2.3e-75 253.8 0.0 2.3 2 0 0 2 2 2 2 AMP-binding enzyme Condensation PF00668.20 CCF35725.1 - 4.2e-71 240.0 0.0 3.4e-35 121.6 0.0 2.2 2 0 0 2 2 2 2 Condensation domain PP-binding PF00550.25 CCF35725.1 - 1.6e-23 82.8 0.1 2.3e-10 40.7 0.0 3.6 3 0 0 3 3 3 2 Phosphopantetheine attachment site AMP-binding_C PF13193.6 CCF35725.1 - 3.9e-07 31.0 0.0 0.046 14.7 0.0 2.8 2 0 0 2 2 2 2 AMP-binding enzyme C-terminal domain Transferase PF02458.15 CCF35725.1 - 2.4e-06 26.5 0.0 0.027 13.1 0.0 2.2 2 0 0 2 2 2 2 Transferase family Imm1 PF14430.6 CCF35725.1 - 0.026 15.2 0.0 0.71 10.5 0.0 2.9 2 0 0 2 2 2 0 Immunity protein Imm1 Pyr_redox_2 PF07992.14 CCF35726.1 - 8.4e-41 140.1 0.3 1.4e-40 139.4 0.3 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NIR_SIR PF01077.22 CCF35726.1 - 5.8e-18 64.9 0.0 1e-17 64.1 0.0 1.4 1 0 0 1 1 1 1 Nitrite and sulphite reductase 4Fe-4S domain Pyr_redox PF00070.27 CCF35726.1 - 2e-16 60.3 1.1 4e-16 59.4 0.2 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Fer2_BFD PF04324.15 CCF35726.1 - 1.1e-15 57.7 6.7 2.1e-11 44.0 6.2 2.8 2 0 0 2 2 2 2 BFD-like [2Fe-2S] binding domain Rieske_2 PF13806.6 CCF35726.1 - 2.4e-13 49.9 0.0 5.2e-06 26.3 0.0 2.8 2 0 0 2 2 2 2 Rieske-like [2Fe-2S] domain Rieske PF00355.26 CCF35726.1 - 1.8e-12 47.0 0.2 3.4e-11 42.9 0.0 2.8 2 1 0 2 2 2 1 Rieske [2Fe-2S] domain NIR_SIR_ferr PF03460.17 CCF35726.1 - 3.1e-08 33.3 0.0 7.1e-08 32.2 0.0 1.7 1 0 0 1 1 1 1 Nitrite/Sulfite reductase ferredoxin-like half domain Rubredoxin_C PF18267.1 CCF35726.1 - 5.6e-06 26.2 0.0 0.086 12.8 0.0 3.6 4 0 0 4 4 4 2 Rubredoxin NAD+ reductase C-terminal domain Amino_oxidase PF01593.24 CCF35726.1 - 0.00011 21.7 0.9 0.3 10.3 0.2 2.3 1 1 0 2 2 2 2 Flavin containing amine oxidoreductase Pyr_redox_3 PF13738.6 CCF35726.1 - 0.00011 21.5 0.0 0.0002 20.7 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CCF35726.1 - 0.15 11.1 0.9 29 3.6 0.1 3.0 2 1 1 3 3 3 0 Glucose inhibited division protein A Fungal_trans_2 PF11951.8 CCF35727.1 - 7.3e-14 51.4 2.9 8.9e-14 51.1 2.1 1.5 2 0 0 2 2 2 1 Fungal specific transcription factor domain p450 PF00067.22 CCF35728.1 - 5.4e-49 167.2 0.0 6.8e-49 166.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 ABC_tran PF00005.27 CCF35729.1 - 3.1e-43 147.6 0.0 1.3e-25 90.5 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 CCF35729.1 - 4e-34 118.5 31.2 1.2e-19 71.1 9.5 3.8 4 0 0 4 4 4 3 ABC transporter transmembrane region SMC_N PF02463.19 CCF35729.1 - 3.5e-13 49.5 0.8 1e-05 25.1 0.0 4.1 3 1 1 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 CCF35729.1 - 1.4e-06 28.4 0.0 0.028 14.2 0.0 4.1 4 0 0 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CCF35729.1 - 5.9e-06 25.9 0.4 0.043 13.6 0.2 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 CCF35729.1 - 7.6e-06 26.2 0.5 0.052 13.8 0.0 3.1 2 1 0 2 2 2 2 AAA domain AAA_16 PF13191.6 CCF35729.1 - 1.6e-05 25.3 0.1 0.19 12.1 0.0 2.9 2 0 0 2 2 2 2 AAA ATPase domain AAA_23 PF13476.6 CCF35729.1 - 1.8e-05 25.3 0.1 0.0062 17.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 CCF35729.1 - 0.00027 20.9 0.0 0.36 10.7 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase T2SSE PF00437.20 CCF35729.1 - 0.00065 18.8 0.4 1.2 8.2 0.0 2.4 2 0 0 2 2 2 2 Type II/IV secretion system protein NACHT PF05729.12 CCF35729.1 - 0.00092 19.2 1.5 0.77 9.7 0.2 2.9 2 0 0 2 2 2 2 NACHT domain DUF87 PF01935.17 CCF35729.1 - 0.0013 18.9 2.6 0.013 15.6 0.3 2.4 2 0 0 2 2 2 1 Helicase HerA, central domain AAA_25 PF13481.6 CCF35729.1 - 0.0014 18.2 0.5 0.044 13.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 CCF35729.1 - 0.0026 17.8 0.1 2.3 8.3 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase SbcCD_C PF13558.6 CCF35729.1 - 0.0062 16.7 0.0 1.4 9.2 0.0 3.1 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA PF00004.29 CCF35729.1 - 0.0079 16.6 0.1 8.9 6.7 0.0 3.2 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Dynamin_N PF00350.23 CCF35729.1 - 0.03 14.4 0.1 2 8.4 0.0 2.4 2 0 0 2 2 2 0 Dynamin family AAA_30 PF13604.6 CCF35729.1 - 0.03 14.0 0.8 9.6 5.9 0.0 3.1 2 1 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 CCF35729.1 - 0.035 13.4 0.2 7.2 5.8 0.1 2.4 2 0 0 2 2 2 0 Zeta toxin DUF2075 PF09848.9 CCF35729.1 - 0.061 12.5 0.8 4.5 6.4 0.0 2.5 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) FtsK_SpoIIIE PF01580.18 CCF35729.1 - 0.064 12.6 0.5 2.5 7.4 0.1 2.5 2 0 0 2 2 2 0 FtsK/SpoIIIE family cobW PF02492.19 CCF35729.1 - 0.066 12.8 2.5 0.23 11.1 0.2 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ATPase_2 PF01637.18 CCF35729.1 - 0.071 13.0 0.0 0.52 10.2 0.0 2.2 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea TsaE PF02367.17 CCF35729.1 - 0.12 12.4 0.1 2.3 8.2 0.0 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE IstB_IS21 PF01695.17 CCF35729.1 - 0.14 11.8 0.2 3.6 7.3 0.0 2.9 3 0 0 3 3 3 0 IstB-like ATP binding protein TrwB_AAD_bind PF10412.9 CCF35729.1 - 0.16 10.9 0.3 8.1 5.2 0.0 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_18 PF13238.6 CCF35729.1 - 0.16 12.5 0.1 33 5.0 0.0 3.1 3 0 0 3 3 3 0 AAA domain ABC_ATPase PF09818.9 CCF35729.1 - 0.44 9.3 1.1 1.1 8.0 0.1 2.0 2 0 0 2 2 2 0 Predicted ATPase of the ABC class PduV-EutP PF10662.9 CCF35729.1 - 0.62 9.8 1.6 4.7 7.0 0.1 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Fungal_trans PF04082.18 CCF35730.1 - 0.06 12.4 0.0 0.1 11.6 0.0 1.3 1 0 0 1 1 1 0 Fungal specific transcription factor domain Mrx7 PF10906.8 CCF35731.1 - 2.8e-07 30.7 0.0 4.8e-07 29.9 0.0 1.4 1 1 0 1 1 1 1 MIOREX complex component 7 Cellulase PF00150.18 CCF35732.1 - 2.4e-15 56.7 0.0 3.4e-15 56.2 0.0 1.2 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) CBM_1 PF00734.18 CCF35732.1 - 4.5e-12 45.7 14.7 8.6e-12 44.8 14.7 1.5 1 0 0 1 1 1 1 Fungal cellulose binding domain SOG2 PF10428.9 CCF35732.1 - 0.0052 16.0 6.6 0.007 15.6 6.6 1.1 1 0 0 1 1 1 1 RAM signalling pathway protein Kei1 PF08552.11 CCF35732.1 - 0.15 11.9 3.3 0.26 11.2 3.3 1.3 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 RNF220 PF15926.5 CCF35732.1 - 0.34 10.5 2.1 0.49 10.0 2.1 1.2 1 0 0 1 1 1 0 E3 ubiquitin-protein ligase RNF220 PLAC8 PF04749.17 CCF35733.1 - 2.6e-23 82.9 13.2 3.4e-23 82.5 13.2 1.1 1 0 0 1 1 1 1 PLAC8 family Acetyltransf_1 PF00583.25 CCF35734.1 - 4.6e-14 52.6 0.0 7e-14 52.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CCF35734.1 - 1.5e-08 34.9 0.0 2.3e-08 34.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CCF35734.1 - 1.4e-06 28.3 0.0 2.1e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CCF35734.1 - 0.0002 21.2 0.0 0.0004 20.3 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.7 CCF35734.1 - 0.0012 19.5 0.0 0.0016 19.2 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 CCF35734.1 - 0.072 13.2 0.0 0.1 12.7 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Corona_5a PF06336.11 CCF35734.1 - 0.095 12.7 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Coronavirus 5a protein Sugar_tr PF00083.24 CCF35735.1 - 6.7e-23 81.3 26.6 3.2e-15 56.0 7.9 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter DUF3808 PF10300.9 CCF35736.1 - 8.7e-131 436.9 0.0 1.1e-130 436.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) HrpB1_HrpK PF09613.10 CCF35736.1 - 0.0019 17.9 1.5 0.0074 15.9 1.5 2.0 1 0 0 1 1 1 1 Bacterial type III secretion protein (HrpB1_HrpK) TPR_2 PF07719.17 CCF35736.1 - 0.026 14.6 1.7 15 6.0 0.0 4.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 CCF35736.1 - 0.22 12.1 7.8 5.2 7.7 0.1 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 CCF35736.1 - 0.28 11.1 3.9 0.47 10.4 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_4 PF07721.14 CCF35736.1 - 0.41 11.4 0.0 0.41 11.4 0.0 4.3 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_12 PF13424.6 CCF35736.1 - 0.5 10.7 5.3 0.58 10.5 0.0 3.7 5 0 0 5 5 5 0 Tetratricopeptide repeat PTS_IIA PF02255.16 CCF35736.1 - 0.72 9.9 6.8 3.2 7.9 0.4 3.6 2 1 1 3 3 3 0 PTS system, Lactose/Cellobiose specific IIA subunit TPR_14 PF13428.6 CCF35736.1 - 1.4 9.9 12.2 4.9 8.2 0.0 5.9 6 0 0 6 6 6 0 Tetratricopeptide repeat Ras PF00071.22 CCF35739.1 - 1.7e-65 219.5 0.5 2e-65 219.3 0.5 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCF35739.1 - 7.1e-36 123.1 0.1 1.3e-35 122.3 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCF35739.1 - 3.2e-16 59.3 0.1 3.9e-16 59.0 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 CCF35739.1 - 1.8e-05 24.7 0.3 0.13 12.2 0.0 2.3 1 1 1 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 CCF35739.1 - 2.6e-05 24.3 0.0 0.0001 22.3 0.0 1.8 1 1 1 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CCF35739.1 - 8.6e-05 22.2 0.4 0.00023 20.8 0.4 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 CCF35739.1 - 0.00027 20.4 0.1 0.00034 20.1 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 CCF35739.1 - 0.00046 19.7 0.0 0.0007 19.1 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA PF00004.29 CCF35739.1 - 0.00077 19.9 0.1 0.17 12.3 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) FeoB_N PF02421.18 CCF35739.1 - 0.0043 16.6 0.0 0.025 14.1 0.0 1.9 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_16 PF13191.6 CCF35739.1 - 0.0095 16.3 0.0 0.013 15.9 0.0 1.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 CCF35739.1 - 0.037 14.3 0.0 0.094 13.0 0.0 1.8 1 1 1 2 2 2 0 AAA domain AAA_29 PF13555.6 CCF35739.1 - 0.057 13.2 0.0 0.15 11.8 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain Septin PF00735.18 CCF35739.1 - 0.066 12.5 0.0 0.18 11.0 0.0 1.7 2 0 0 2 2 2 0 Septin TniB PF05621.11 CCF35739.1 - 0.074 12.5 0.0 0.21 11.0 0.0 1.7 2 0 0 2 2 2 0 Bacterial TniB protein AAA_5 PF07728.14 CCF35739.1 - 0.084 12.9 0.0 0.13 12.3 0.0 1.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 CCF35739.1 - 0.086 12.4 0.0 0.18 11.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region ABC_tran PF00005.27 CCF35739.1 - 0.096 13.2 0.1 0.16 12.5 0.1 1.6 1 1 0 1 1 1 0 ABC transporter LANC_like PF05147.13 CCF35739.1 - 0.1 11.2 0.0 0.25 9.9 0.0 1.8 1 1 0 1 1 1 0 Lanthionine synthetase C-like protein PduV-EutP PF10662.9 CCF35739.1 - 0.11 12.3 0.1 1.4 8.7 0.0 2.2 1 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_25 PF13481.6 CCF35739.1 - 0.2 11.2 0.1 1.5 8.4 0.0 2.2 2 1 0 2 2 2 0 AAA domain Rad51 PF08423.11 CCF35741.1 - 3.9e-40 137.7 0.0 2.4e-37 128.6 0.0 2.0 2 0 0 2 2 2 2 Rad51 AAA_25 PF13481.6 CCF35741.1 - 1.2e-07 31.5 0.0 2.8e-07 30.3 0.0 1.6 1 1 0 1 1 1 1 AAA domain RecA PF00154.21 CCF35741.1 - 3.6e-06 26.7 0.0 0.0014 18.1 0.0 2.1 2 0 0 2 2 2 2 recA bacterial DNA recombination protein ATPase PF06745.13 CCF35741.1 - 5.2e-06 26.0 0.0 1e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 KaiC AAA_24 PF13479.6 CCF35741.1 - 0.0099 15.6 0.0 0.038 13.7 0.0 1.8 1 1 0 1 1 1 1 AAA domain DnaB_C PF03796.15 CCF35741.1 - 0.039 13.3 0.0 8.2 5.7 0.0 2.2 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain AAA_22 PF13401.6 CCF35741.1 - 0.13 12.6 0.0 0.33 11.2 0.0 1.8 1 1 0 1 1 1 0 AAA domain Pox_A32 PF04665.12 CCF35741.1 - 0.29 10.6 0.2 0.55 9.6 0.2 1.4 1 0 0 1 1 1 0 Poxvirus A32 protein CHZ PF09649.10 CCF35743.1 - 0.0012 18.3 0.6 0.0025 17.2 0.6 1.5 1 0 0 1 1 1 1 Histone chaperone domain CHZ AA_permease_2 PF13520.6 CCF35744.1 - 2.5e-79 267.1 34.0 3.1e-79 266.8 34.0 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CCF35744.1 - 7.7e-18 64.3 29.3 1e-17 63.9 29.3 1.1 1 0 0 1 1 1 1 Amino acid permease Aa_trans PF01490.18 CCF35744.1 - 0.12 11.1 14.9 0.048 12.4 6.3 2.7 3 1 0 3 3 3 0 Transmembrane amino acid transporter protein PHD PF00628.29 CCF35745.1 - 4.7e-08 32.8 9.0 9.2e-08 31.9 9.0 1.5 1 0 0 1 1 1 1 PHD-finger SET PF00856.28 CCF35745.1 - 2.2e-05 24.9 0.2 7.6e-05 23.2 0.0 2.0 2 1 0 2 2 2 1 SET domain Glycos_transf_4 PF00953.21 CCF35746.1 - 1.9e-28 99.5 8.8 1.9e-28 99.5 8.8 2.2 2 0 0 2 2 2 1 Glycosyl transferase family 4 Methyltransf_8 PF05148.15 CCF35747.1 - 5.2e-21 75.5 0.1 7.9e-21 74.9 0.1 1.2 1 0 0 1 1 1 1 Hypothetical methyltransferase DUF1387 PF07139.11 CCF35747.1 - 0.2 11.3 21.5 0.24 11.1 21.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) DUF5094 PF17015.5 CCF35747.1 - 1.5 8.9 13.3 0.38 10.9 3.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5094) Fungal_trans_2 PF11951.8 CCF35748.1 - 9e-20 70.8 0.4 7.5e-11 41.5 0.1 3.1 3 0 0 3 3 3 3 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF35748.1 - 5.8e-09 35.9 11.2 9.4e-09 35.3 11.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Proteasome PF00227.26 CCF35749.1 - 6.3e-57 192.1 0.1 8.1e-57 191.8 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 CCF35749.1 - 1.6e-12 46.8 0.0 3.6e-12 45.7 0.0 1.7 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature GCP_N_terminal PF17681.1 CCF35750.1 - 3.7e-64 217.3 0.0 6.9e-64 216.4 0.0 1.4 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 CCF35750.1 - 1.2e-60 205.7 0.7 1.2e-60 205.7 0.7 1.8 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal YqeY PF09424.10 CCF35751.1 - 2.2e-17 63.5 2.4 2.5e-17 63.3 2.4 1.1 1 0 0 1 1 1 1 Yqey-like protein DUF2017 PF09438.10 CCF35751.1 - 0.0016 18.3 0.8 0.0017 18.3 0.8 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF2017) F-box-like PF12937.7 CCF35752.1 - 1e-08 34.9 0.1 1.9e-08 34.1 0.1 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCF35752.1 - 2.8e-07 30.2 0.0 7.7e-07 28.8 0.0 1.8 1 0 0 1 1 1 1 F-box domain T-box_assoc PF16176.5 CCF35752.1 - 0.071 13.2 1.8 0.62 10.1 0.0 2.4 2 0 0 2 2 2 0 T-box transcription factor-associated UIM PF02809.20 CCF35752.1 - 0.24 11.4 27.5 0.53 10.3 2.5 4.8 4 0 0 4 4 4 0 Ubiquitin interaction motif Asp PF00026.23 CCF35754.1 - 4.7e-08 32.8 2.7 3e-07 30.2 2.7 2.1 1 1 0 1 1 1 1 Eukaryotic aspartyl protease Adeno_E3_CR2 PF02439.15 CCF35754.1 - 0.16 11.7 1.0 0.33 10.7 1.0 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Flavodoxin_1 PF00258.25 CCF35755.1 - 9.9e-32 110.1 0.0 1.6e-31 109.5 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin FAD_binding_1 PF00667.20 CCF35755.1 - 9e-23 81.0 0.0 5.7e-21 75.1 0.0 2.5 2 1 0 2 2 2 1 FAD binding domain NAD_binding_1 PF00175.21 CCF35755.1 - 9.4e-09 35.9 0.0 3.5e-08 34.1 0.0 2.0 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain Flavodoxin_3 PF12641.7 CCF35755.1 - 0.035 13.8 0.0 0.073 12.8 0.0 1.5 1 0 0 1 1 1 0 Flavodoxin domain Flavodoxin_5 PF12724.7 CCF35755.1 - 0.096 12.9 0.0 0.24 11.6 0.0 1.7 1 0 0 1 1 1 0 Flavodoxin domain EHN PF06441.12 CCF35757.1 - 1.4e-26 92.9 0.0 2.4e-26 92.2 0.0 1.4 1 0 0 1 1 1 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 CCF35757.1 - 4.5e-05 23.2 0.0 0.00018 21.2 0.0 1.9 2 0 0 2 2 2 1 alpha/beta hydrolase fold HET PF06985.11 CCF35758.1 - 4.4e-22 79.0 0.1 7.4e-22 78.3 0.1 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Aminotran_4 PF01063.19 CCF35759.1 - 1.6e-18 67.4 0.0 5.2e-18 65.7 0.0 1.7 2 0 0 2 2 2 1 Amino-transferase class IV MFS_1 PF07690.16 CCF35760.1 - 6.5e-25 87.8 37.5 1.6e-24 86.5 34.0 2.6 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF35760.1 - 7.2e-12 44.9 6.2 7.2e-12 44.9 6.2 2.4 3 0 0 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.13 CCF35760.1 - 5e-06 25.2 10.2 7.4e-06 24.7 10.2 1.3 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_4 PF06779.14 CCF35760.1 - 0.0057 16.0 9.3 0.0057 16.0 9.3 3.2 2 1 1 3 3 3 1 Uncharacterised MFS-type transporter YbfB p450 PF00067.22 CCF35762.1 - 3.6e-24 85.3 0.0 3.9e-24 85.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 PLDc PF00614.22 CCF35763.1 - 1.1e-16 60.2 0.4 1.1e-07 31.7 0.2 2.7 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_2 PF13091.6 CCF35763.1 - 1.1e-13 51.2 0.0 1.1e-07 31.8 0.0 2.7 2 0 0 2 2 2 2 PLD-like domain PX PF00787.24 CCF35763.1 - 2.3e-07 30.8 0.0 4e-06 26.8 0.0 3.0 3 1 0 3 3 3 1 PX domain PH_2 PF08458.10 CCF35763.1 - 0.057 13.8 0.9 0.11 12.8 0.9 1.5 1 0 0 1 1 1 0 Plant pleckstrin homology-like region Mcp5_PH PF12814.7 CCF35765.1 - 7.4e-45 152.0 0.0 1.4e-44 151.1 0.0 1.4 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology PH_12 PF16457.5 CCF35765.1 - 0.047 14.2 0.1 0.2 12.2 0.1 2.0 1 1 0 1 1 1 0 Pleckstrin homology domain Peptidase_M24 PF00557.24 CCF35766.1 - 2.9e-51 174.1 0.1 3.8e-51 173.8 0.1 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 CCF35766.1 - 5.5e-25 87.5 0.0 1.1e-24 86.5 0.0 1.5 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain DUF4263 PF14082.6 CCF35766.1 - 0.062 13.6 0.0 0.11 12.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4263) Peptidase_C12 PF01088.21 CCF35767.1 - 2.7e-53 180.9 0.0 3.4e-53 180.5 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 NicO PF03824.16 CCF35768.1 - 1.3e-67 228.1 3.9 1.9e-67 227.6 3.9 1.2 1 0 0 1 1 1 1 High-affinity nickel-transport protein NAD_binding_8 PF13450.6 CCF35770.1 - 9.7e-12 45.0 0.0 2.3e-11 43.7 0.0 1.6 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FMO-like PF00743.19 CCF35770.1 - 4.6e-10 38.5 0.1 1.9e-09 36.5 0.1 1.7 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like NAD_binding_9 PF13454.6 CCF35770.1 - 2e-05 24.6 0.1 0.00099 19.1 0.1 2.1 1 1 0 1 1 1 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 CCF35770.1 - 0.00036 19.9 0.0 0.00045 19.5 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCF35770.1 - 0.00044 20.0 0.0 0.039 13.5 0.0 2.0 1 1 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.14 CCF35770.1 - 0.17 10.6 0.0 0.26 9.9 0.0 1.3 1 0 0 1 1 1 0 HI0933-like protein Thi4 PF01946.17 CCF35770.1 - 0.19 11.0 0.0 0.33 10.2 0.0 1.3 1 0 0 1 1 1 0 Thi4 family Polysacc_deac_1 PF01522.21 CCF35771.1 - 2.1e-14 53.5 0.0 3.7e-14 52.7 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase CIA30 PF08547.12 CCF35771.1 - 7.7e-06 26.0 0.0 0.0087 16.1 0.0 3.2 3 0 0 3 3 3 1 Complex I intermediate-associated protein 30 (CIA30) Exop_C PF18559.1 CCF35771.1 - 0.00024 21.0 0.0 0.001 19.0 0.1 2.1 2 0 0 2 2 2 1 Galactose-binding domain-like SGBP_B_XBD PF18329.1 CCF35771.1 - 0.0057 16.6 0.2 0.018 15.0 0.2 1.9 1 0 0 1 1 1 1 Surface glycan-binding protein B xyloglucan binding domain Endotoxin_C PF03944.14 CCF35771.1 - 0.015 15.7 0.0 2.9 8.2 0.0 2.7 2 0 0 2 2 2 0 delta endotoxin FimH_man-bind PF09160.10 CCF35771.1 - 0.049 13.3 0.3 0.17 11.6 0.2 1.9 1 1 0 1 1 1 0 FimH, mannose binding GMC_oxred_N PF00732.19 CCF35772.1 - 6.3e-52 176.8 0.0 8.3e-52 176.4 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCF35772.1 - 4.8e-24 85.5 0.2 7.9e-24 84.8 0.2 1.4 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 CCF35772.1 - 8.7e-05 21.8 0.1 0.028 13.5 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 CCF35772.1 - 0.0035 17.0 0.0 0.067 12.8 0.0 2.4 3 0 0 3 3 3 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CCF35772.1 - 0.01 16.1 0.2 0.029 14.6 0.2 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 CCF35772.1 - 0.073 12.3 0.1 0.073 12.3 0.1 1.8 2 0 0 2 2 2 0 Thi4 family Pyr_redox_3 PF13738.6 CCF35772.1 - 0.082 12.1 0.0 0.85 8.8 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CCF35772.1 - 0.11 11.7 0.0 0.85 8.8 0.0 2.2 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Lipase_GDSL_2 PF13472.6 CCF35773.1 - 2.7e-09 37.7 4.5 5.5e-09 36.7 4.5 1.6 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 CCF35773.1 - 8e-08 32.5 0.0 1.4e-07 31.7 0.0 1.4 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Peptidase_M13_N PF05649.13 CCF35776.1 - 3.6e-65 221.1 0.0 5.8e-65 220.4 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13 PF01431.21 CCF35776.1 - 1.6e-61 207.5 2.9 3.2e-61 206.5 2.9 1.5 1 0 0 1 1 1 1 Peptidase family M13 PilJ PF13675.6 CCF35776.1 - 0.12 12.4 0.2 0.26 11.3 0.2 1.5 1 0 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term Ferrochelatase PF00762.19 CCF35776.1 - 0.15 11.1 0.1 0.82 8.7 0.0 2.1 2 0 0 2 2 2 0 Ferrochelatase Pkinase PF00069.25 CCF35778.1 - 3.9e-69 232.9 0.0 5.4e-69 232.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF35778.1 - 2.4e-31 109.0 0.0 3.1e-31 108.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 CCF35778.1 - 1.4e-12 48.1 3.4 1.7e-12 47.8 1.5 2.3 2 0 0 2 2 2 1 Protein kinase C terminal domain C2 PF00168.30 CCF35778.1 - 4.5e-10 39.7 0.0 3.4e-07 30.5 0.0 2.6 2 0 0 2 2 2 2 C2 domain Kinase-like PF14531.6 CCF35778.1 - 2.5e-09 36.9 0.0 8.3e-09 35.2 0.0 1.7 1 1 1 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 CCF35778.1 - 0.0014 17.7 0.5 0.0042 16.1 0.1 1.9 2 0 0 2 2 2 1 Haspin like kinase domain Adeno_E3_15_3 PF03307.14 CCF35778.1 - 0.0052 16.7 0.0 0.013 15.5 0.0 1.6 1 0 0 1 1 1 1 Adenovirus 15.3kD protein in E3 region Kdo PF06293.14 CCF35778.1 - 0.012 14.9 0.1 0.021 14.1 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CCF35778.1 - 0.043 13.7 0.0 0.088 12.7 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family FTA2 PF13095.6 CCF35778.1 - 0.045 13.4 1.7 2.6 7.6 0.2 3.1 3 1 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 Choline_kinase PF01633.20 CCF35778.1 - 0.062 12.9 0.1 0.12 12.0 0.1 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase ATP_sub_h PF10775.9 CCF35779.1 - 1.7e-26 92.0 0.6 1.7e-26 92.0 0.6 1.4 2 0 0 2 2 2 1 ATP synthase complex subunit h ATP-synt_F6 PF05511.11 CCF35779.1 - 0.11 12.9 0.0 0.14 12.6 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ATP synthase coupling factor 6 CDH-cyt PF16010.5 CCF35780.1 - 4.1e-25 88.5 6.9 4.1e-25 88.5 6.9 1.8 2 0 0 2 2 2 1 Cytochrome domain of cellobiose dehydrogenase DOMON PF03351.17 CCF35780.1 - 1.5e-07 31.7 0.5 3.3e-07 30.6 0.5 1.5 1 0 0 1 1 1 1 DOMON domain DUF2427 PF10348.9 CCF35780.1 - 7.5e-06 25.7 7.8 7.5e-06 25.7 7.8 2.2 1 1 1 2 2 2 1 Domain of unknown function (DUF2427) HeLo PF14479.6 CCF35785.1 - 0.00059 19.7 1.7 0.0016 18.3 0.3 2.1 1 1 1 2 2 2 1 Prion-inhibition and propagation Helo_like_N PF17111.5 CCF35785.1 - 0.018 14.4 0.1 0.059 12.7 0.1 2.1 1 1 0 1 1 1 0 Fungal N-terminal domain of STAND proteins PARP_regulatory PF01358.18 CCF35785.1 - 0.037 13.0 0.1 0.057 12.3 0.1 1.2 1 0 0 1 1 1 0 Poly A polymerase regulatory subunit Prefoldin_2 PF01920.20 CCF35785.1 - 0.14 12.1 0.8 0.57 10.2 0.0 2.3 3 0 0 3 3 3 0 Prefoldin subunit SRR1 PF07985.12 CCF35786.1 - 1.4e-09 37.9 0.0 2.3e-09 37.1 0.0 1.4 1 0 0 1 1 1 1 SRR1 Lactamase_B PF00753.27 CCF35789.1 - 1.1e-09 38.6 0.5 5.1e-09 36.4 0.5 1.9 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CCF35789.1 - 2.7e-05 23.8 0.3 5.6e-05 22.7 0.2 1.5 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Chromo PF00385.24 CCF35790.1 - 0.0063 16.4 0.4 0.021 14.7 0.1 1.9 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain ORC6 PF05460.13 CCF35790.1 - 6.9 5.8 11.0 11 5.2 11.0 1.3 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Methyltransf_16 PF10294.9 CCF35791.1 - 1.3e-14 54.3 0.0 2e-14 53.7 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_12 PF08242.12 CCF35791.1 - 0.00072 20.3 0.0 0.0015 19.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF35791.1 - 0.035 14.8 0.0 0.088 13.5 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain AhpC-TSA PF00578.21 CCF35792.1 - 1.5e-37 128.3 0.0 2e-37 127.9 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 CCF35792.1 - 6.2e-12 45.5 0.0 8.4e-12 45.0 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 CCF35792.1 - 6.4e-12 45.1 0.0 1.1e-11 44.4 0.0 1.4 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin PhzC-PhzF PF02567.16 CCF35794.1 - 6.3e-12 45.5 0.0 8.5e-12 45.1 0.0 1.4 1 1 0 1 1 1 1 Phenazine biosynthesis-like protein RVT_1 PF00078.27 CCF35795.1 - 9.1e-40 136.5 0.0 1.3e-39 136.1 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.24 CCF35795.1 - 1.5e-11 44.6 0.0 3.1e-11 43.7 0.0 1.5 1 0 0 1 1 1 1 RNase H RVT_3 PF13456.6 CCF35795.1 - 0.016 15.0 0.8 0.065 13.0 0.1 2.5 3 0 0 3 3 3 0 Reverse transcriptase-like Not3 PF04065.15 CCF35798.1 - 9.8e-91 303.3 26.4 1.1e-90 303.1 26.4 1.0 1 0 0 1 1 1 1 Not1 N-terminal domain, CCR4-Not complex component Syntaxin_2 PF14523.6 CCF35798.1 - 0.01 16.2 4.3 0.01 16.2 4.3 2.5 2 1 0 2 2 2 0 Syntaxin-like protein HUN PF08729.10 CCF35798.1 - 0.037 14.0 1.4 0.037 14.0 1.4 2.0 2 0 0 2 2 2 0 HPC2 and ubinuclein domain DASH_Dad2 PF08654.10 CCF35798.1 - 0.11 13.0 7.5 0.18 12.2 0.8 2.9 2 1 0 2 2 2 0 DASH complex subunit Dad2 DUF3450 PF11932.8 CCF35798.1 - 0.17 11.1 20.0 0.15 11.3 6.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Sec5 PF15469.6 CCF35798.1 - 0.22 11.3 11.7 0.048 13.5 2.1 2.3 2 0 0 2 2 2 0 Exocyst complex component Sec5 Nnf1 PF03980.14 CCF35798.1 - 0.43 11.0 18.3 1.3 9.4 12.0 3.3 2 1 1 3 3 3 0 Nnf1 Cep57_MT_bd PF06657.13 CCF35798.1 - 0.51 10.8 14.4 0.51 10.8 2.7 3.0 3 0 0 3 3 2 0 Centrosome microtubule-binding domain of Cep57 DUF1192 PF06698.11 CCF35798.1 - 0.52 10.4 13.0 0.041 13.9 4.0 3.3 3 1 1 4 4 3 0 Protein of unknown function (DUF1192) SNARE PF05739.19 CCF35798.1 - 0.69 10.0 3.6 1.3 9.1 1.0 2.6 2 1 0 2 2 2 0 SNARE domain LPP PF04728.13 CCF35798.1 - 1.3 9.5 9.5 0.9 10.0 1.3 3.3 2 2 1 3 3 3 0 Lipoprotein leucine-zipper DUF948 PF06103.11 CCF35798.1 - 2.1 8.7 4.9 13 6.1 0.6 3.0 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF4140 PF13600.6 CCF35798.1 - 2.2 8.8 11.7 2.3 8.7 2.8 2.8 2 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Vps51 PF08700.11 CCF35798.1 - 2.4 8.3 8.3 7.6 6.7 1.2 2.6 2 0 0 2 2 2 0 Vps51/Vps67 CorA PF01544.18 CCF35798.1 - 2.7 7.2 8.8 0.36 10.1 3.0 2.0 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein FlaC_arch PF05377.11 CCF35798.1 - 4.6 7.7 11.9 3.8 8.0 0.8 4.2 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) Sulfatase_C PF14707.6 CCF35798.1 - 4.7 8.0 6.5 1.7 9.4 1.6 2.5 1 1 0 2 2 2 0 C-terminal region of aryl-sulfatase TSC22 PF01166.18 CCF35798.1 - 5.1 7.5 7.4 5.2 7.4 0.4 3.0 3 1 0 3 3 3 0 TSC-22/dip/bun family JIP_LZII PF16471.5 CCF35798.1 - 5.4 7.3 12.1 0.082 13.1 1.3 3.0 3 0 0 3 3 2 0 JNK-interacting protein leucine zipper II NPV_P10 PF05531.12 CCF35798.1 - 8.3 7.0 7.7 6.4 7.3 0.8 3.4 2 2 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Tyr_Deacylase PF02580.16 CCF35799.1 - 1.1e-46 158.9 0.0 1.3e-46 158.7 0.0 1.0 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase Pro_isomerase PF00160.21 CCF35800.1 - 1.2e-37 129.6 0.0 1.9e-37 129.0 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_2 PF07719.17 CCF35800.1 - 3.1e-06 26.9 1.4 0.00053 19.9 0.0 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 CCF35800.1 - 0.00012 21.8 1.4 0.0022 17.7 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 CCF35800.1 - 0.047 13.4 1.8 11 5.8 0.1 3.2 2 1 1 3 3 3 0 TPR repeat TPR_9 PF13371.6 CCF35800.1 - 0.051 13.7 0.3 0.13 12.5 0.2 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 CCF35800.1 - 0.18 12.5 0.7 0.49 11.1 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat Abhydrolase_6 PF12697.7 CCF35802.1 - 7e-08 33.3 5.3 1.2e-07 32.6 5.3 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCF35802.1 - 0.00018 20.8 0.2 0.0004 19.7 0.1 1.5 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CCF35802.1 - 0.0023 17.6 0.7 0.016 14.8 0.7 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CCF35802.1 - 0.088 12.3 0.0 1 8.8 0.0 2.4 3 0 0 3 3 3 0 Prolyl oligopeptidase family TAF4 PF05236.14 CCF35803.1 - 2.8e-25 89.6 6.5 1e-20 74.7 6.2 2.2 2 0 0 2 2 2 2 Transcription initiation factor TFIID component TAF4 family TTL PF03133.15 CCF35804.1 - 2.6e-52 177.8 0.0 3.9e-52 177.2 0.0 1.2 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family SurE PF01975.17 CCF35804.1 - 3.3e-52 177.1 0.0 4.8e-52 176.6 0.0 1.2 1 0 0 1 1 1 1 Survival protein SurE ATPgrasp_YheCD PF14398.6 CCF35804.1 - 0.00014 21.3 0.0 0.00037 19.8 0.0 1.7 2 0 0 2 2 2 1 YheC/D like ATP-grasp Cation_ATPase_C PF00689.21 CCF35805.1 - 3e-43 147.7 7.8 3e-43 147.7 7.8 2.1 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 CCF35805.1 - 2.7e-35 121.5 0.9 2.7e-35 121.5 0.9 3.0 3 1 0 3 3 3 1 E1-E2 ATPase Cation_ATPase PF13246.6 CCF35805.1 - 1.2e-22 79.8 0.0 2.3e-22 78.9 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 CCF35805.1 - 1.2e-20 74.7 0.0 2.6e-20 73.6 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 CCF35805.1 - 8.6e-06 25.7 0.8 1.9e-05 24.5 0.4 1.7 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 CCF35805.1 - 1.4e-05 24.7 0.0 7e-05 22.4 0.0 2.2 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus HAD PF12710.7 CCF35805.1 - 0.05 14.0 0.0 0.095 13.1 0.0 1.4 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase PrgI PF12666.7 CCF35805.1 - 0.28 11.9 4.8 4 8.2 0.3 3.7 3 0 0 3 3 3 0 PrgI family protein Pyr_redox_3 PF13738.6 CCF35806.1 - 1.2e-24 87.1 0.0 5.7e-22 78.3 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CCF35806.1 - 2.3e-17 63.2 0.1 4.8e-13 49.0 0.0 2.7 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 CCF35806.1 - 5.4e-17 61.4 0.0 7e-16 57.7 0.0 2.1 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like K_oxygenase PF13434.6 CCF35806.1 - 9.6e-16 57.8 0.1 5.6e-13 48.8 0.0 3.0 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_3 PF01494.19 CCF35806.1 - 5.4e-09 35.8 0.1 0.00044 19.6 0.0 2.3 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 CCF35806.1 - 3.2e-06 27.0 0.4 0.00059 19.5 0.1 2.4 2 1 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 CCF35806.1 - 4.4e-05 23.5 1.2 0.46 10.5 0.1 3.0 2 1 1 3 3 3 2 FAD-NAD(P)-binding Pyr_redox PF00070.27 CCF35806.1 - 4.5e-05 23.9 0.0 0.3 11.7 0.0 3.4 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 CCF35806.1 - 0.0021 17.4 0.5 0.2 10.9 0.4 2.8 2 1 0 2 2 2 1 Flavin containing amine oxidoreductase FAD_binding_2 PF00890.24 CCF35806.1 - 0.0037 16.4 0.1 0.079 12.0 0.0 2.2 2 0 0 2 2 2 1 FAD binding domain GIDA PF01134.22 CCF35806.1 - 0.0063 15.7 0.2 12 4.9 0.0 3.1 3 0 0 3 3 3 2 Glucose inhibited division protein A Lycopene_cycl PF05834.12 CCF35806.1 - 0.0098 15.0 0.3 0.11 11.6 0.1 2.7 2 1 0 2 2 2 1 Lycopene cyclase protein Shikimate_DH PF01488.20 CCF35806.1 - 0.011 15.8 0.0 0.64 10.1 0.0 2.9 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase HI0933_like PF03486.14 CCF35806.1 - 0.055 12.2 0.2 6.5 5.3 0.0 2.9 3 0 0 3 3 3 0 HI0933-like protein TPR_2 PF07719.17 CCF35807.1 - 1.7e-10 40.2 5.8 1.7e-05 24.5 0.2 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 CCF35807.1 - 1.2e-07 31.2 2.9 0.034 14.0 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 CCF35807.1 - 1.3e-06 28.1 0.5 0.00086 19.3 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 CCF35807.1 - 8.1e-06 26.0 1.5 0.0044 17.3 0.7 3.0 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 CCF35807.1 - 7.5e-05 23.2 1.0 0.0014 19.1 0.2 2.8 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 CCF35807.1 - 0.00064 20.3 9.1 0.009 16.6 3.1 2.7 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 CCF35807.1 - 0.075 13.1 2.9 22 5.4 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 CCF35807.1 - 0.095 12.4 2.4 7.2 6.4 0.0 3.1 3 0 0 3 3 3 0 TPR repeat TPR_4 PF07721.14 CCF35807.1 - 0.23 12.2 0.6 0.23 12.2 0.6 3.1 3 1 0 3 3 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 CCF35807.1 - 0.32 11.7 1.8 1.4 9.7 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 CCF35807.1 - 0.33 10.9 3.4 4.1 7.4 0.1 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 CCF35807.1 - 0.51 11.3 10.3 0.21 12.5 1.2 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat CAML PF14963.6 CCF35808.1 - 0.058 13.5 0.4 0.063 13.4 0.4 1.0 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand LysM PF01476.20 CCF35809.1 - 0.00049 20.1 0.0 0.0008 19.4 0.0 1.3 1 0 0 1 1 1 1 LysM domain UBA_4 PF14555.6 CCF35809.1 - 0.01 15.6 0.0 0.017 14.9 0.0 1.3 1 0 0 1 1 1 0 UBA-like domain MMS1_N PF10433.9 CCF35810.1 - 1.9e-159 531.5 0.0 3.9e-159 530.4 0.0 1.6 2 0 0 2 2 2 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 CCF35810.1 - 6.5e-102 341.1 0.0 2.3e-101 339.3 0.0 1.9 2 0 0 2 2 2 1 CPSF A subunit region ANAPC4_WD40 PF12894.7 CCF35810.1 - 0.15 12.3 0.0 4.2 7.7 0.0 3.2 3 1 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain PQ-loop PF04193.14 CCF35812.1 - 5.9e-08 32.4 2.8 3.3e-07 30.0 2.8 2.0 1 1 0 1 1 1 1 PQ loop repeat Exo_endo_phos PF03372.23 CCF35813.1 - 1.1e-10 41.4 0.2 3.3e-10 39.9 0.2 1.7 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 CCF35813.1 - 0.038 13.8 0.0 0.095 12.5 0.0 1.6 1 1 0 1 1 1 0 Endonuclease-reverse transcriptase RTA1 PF04479.13 CCF35814.1 - 1.8e-71 240.0 9.0 2.6e-71 239.5 9.0 1.2 1 0 0 1 1 1 1 RTA1 like protein Sugar_tr PF00083.24 CCF35816.1 - 6.4e-96 321.9 19.7 7.3e-96 321.8 19.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF35816.1 - 2.9e-13 49.5 37.1 3.7e-09 36.0 14.1 2.2 1 1 0 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 CCF35816.1 - 0.0012 17.5 1.0 0.0012 17.5 1.0 2.6 2 2 0 2 2 2 2 MFS/sugar transport protein MscL PF01741.18 CCF35817.1 - 0.11 12.8 0.1 0.14 12.4 0.1 1.1 1 0 0 1 1 1 0 Large-conductance mechanosensitive channel, MscL SUR7 PF06687.12 CCF35818.1 - 4.1e-27 95.2 0.7 4.8e-27 95.0 0.7 1.0 1 0 0 1 1 1 1 SUR7/PalI family Fig1 PF12351.8 CCF35818.1 - 3.7e-07 30.3 5.6 3.7e-07 30.3 5.6 1.7 2 0 0 2 2 2 1 Ca2+ regulator and membrane fusion protein Fig1 TMEM192 PF14802.6 CCF35818.1 - 0.081 12.0 1.0 0.24 10.5 0.1 1.9 2 0 0 2 2 2 0 TMEM192 family DUF2569 PF10754.9 CCF35818.1 - 1.2 9.6 14.8 1.3 9.5 2.7 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF2569) SCAMP PF04144.13 CCF35818.1 - 1.4 9.2 7.4 1.4 9.2 0.9 2.5 3 0 0 3 3 3 0 SCAMP family MerC PF03203.14 CCF35818.1 - 3.5 8.1 8.3 8.4 6.9 5.0 2.3 2 0 0 2 2 2 0 MerC mercury resistance protein ABC_tran PF00005.27 CCF35819.1 - 6.1e-20 72.1 0.0 1e-19 71.4 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CCF35819.1 - 9.5e-06 25.6 0.0 0.052 13.4 0.0 2.3 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_33 PF13671.6 CCF35819.1 - 0.01 16.0 0.0 0.02 15.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 CCF35819.1 - 0.033 13.9 0.1 0.093 12.5 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_27 PF13514.6 CCF35819.1 - 0.04 13.5 0.0 11 5.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain T2SSE PF00437.20 CCF35819.1 - 0.053 12.6 0.0 0.096 11.7 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein SMC_N PF02463.19 CCF35819.1 - 0.075 12.4 0.0 0.51 9.7 0.0 1.7 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 CCF35819.1 - 0.092 12.6 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase MMR_HSR1 PF01926.23 CCF35819.1 - 0.2 11.8 0.0 0.38 10.8 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_7 PF12775.7 CCF35819.1 - 0.2 11.1 0.0 0.4 10.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region EXS PF03124.14 CCF35820.1 - 4.1e-102 341.9 26.8 5e-102 341.6 26.8 1.1 1 0 0 1 1 1 1 EXS family SPX PF03105.19 CCF35820.1 - 4.3e-88 296.8 3.9 4.3e-88 296.8 3.9 2.2 2 0 0 2 2 2 1 SPX domain DUF883 PF05957.13 CCF35820.1 - 0.18 12.4 1.5 0.95 10.1 1.5 2.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) NOA36 PF06524.12 CCF35820.1 - 4.3 6.6 10.7 8.3 5.6 10.7 1.4 1 0 0 1 1 1 0 NOA36 protein Coq4 PF05019.13 CCF35822.1 - 5e-92 307.2 0.0 5.9e-92 307.0 0.0 1.0 1 0 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 SET PF00856.28 CCF35823.1 - 1e-07 32.5 0.0 1.7e-07 31.8 0.0 1.4 1 0 0 1 1 1 1 SET domain RRM_1 PF00076.22 CCF35824.1 - 0.00013 21.7 0.0 0.00022 21.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Tht1 PF04163.12 CCF35825.1 - 8.9e-11 41.2 3.0 1.8e-10 40.3 3.0 1.3 1 1 0 1 1 1 1 Tht1-like nuclear fusion protein Allexi_40kDa PF05549.11 CCF35825.1 - 0.033 13.7 3.6 0.053 13.0 3.6 1.3 1 0 0 1 1 1 0 Allexivirus 40kDa protein SLX9 PF15341.6 CCF35825.1 - 0.12 12.8 1.6 0.22 11.9 1.6 1.4 1 0 0 1 1 1 0 Ribosome biogenesis protein SLX9 Phasin PF05597.11 CCF35825.1 - 0.16 12.0 4.5 0.066 13.2 1.7 1.8 2 0 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) TMPIT PF07851.13 CCF35825.1 - 0.19 10.9 1.9 0.27 10.4 1.9 1.2 1 0 0 1 1 1 0 TMPIT-like protein ApoLp-III PF07464.11 CCF35825.1 - 1.8 8.7 8.2 1.8 8.7 5.7 2.1 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) L27 PF02828.16 CCF35825.1 - 6.2 6.7 8.5 39 4.1 0.4 3.8 4 0 0 4 4 4 0 L27 domain AATF-Che1 PF13339.6 CCF35825.1 - 7.2 7.3 7.2 59 4.3 7.3 2.3 1 1 0 1 1 1 0 Apoptosis antagonizing transcription factor CN_hydrolase PF00795.22 CCF35826.1 - 1.4e-29 103.2 0.0 1.8e-29 102.9 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Fungal_trans PF04082.18 CCF35827.1 - 1.1e-13 50.8 0.0 1.6e-13 50.3 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Sugar_tr PF00083.24 CCF35828.1 - 9.5e-83 278.5 24.0 1.1e-82 278.3 24.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF35828.1 - 1.3e-18 67.0 30.4 1.3e-18 67.0 30.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Nuc_H_symport PF03825.16 CCF35828.1 - 8.5e-06 25.0 2.0 1.6e-05 24.1 2.0 1.4 1 0 0 1 1 1 1 Nucleoside H+ symporter MFS_2 PF13347.6 CCF35828.1 - 0.035 12.7 24.2 0.042 12.4 7.0 2.9 2 1 1 3 3 3 0 MFS/sugar transport protein GH131_N PF18271.1 CCF35829.1 - 1.5e-78 264.1 0.7 1.7e-78 263.9 0.7 1.0 1 0 0 1 1 1 1 Glycoside hydrolase 131 catalytic N-terminal domain SIR2 PF02146.17 CCF35830.1 - 1.2e-30 106.8 0.0 1.2e-09 38.4 0.0 3.2 3 0 0 3 3 3 3 Sir2 family CCDC117 PF15810.5 CCF35830.1 - 7.7 6.8 8.4 1 9.7 2.2 2.6 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 117 RCC1 PF00415.18 CCF35832.1 - 3.1e-55 184.6 5.7 5e-10 39.9 0.0 7.3 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 CCF35832.1 - 2.1e-35 119.8 26.3 2e-08 33.8 1.1 6.2 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat Amidase PF01425.21 CCF35834.1 - 3.5e-58 197.7 0.2 4.6e-58 197.3 0.2 1.1 1 0 0 1 1 1 1 Amidase CN_hydrolase PF00795.22 CCF35835.1 - 3.2e-26 92.2 0.0 4.8e-26 91.7 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase adh_short PF00106.25 CCF35836.1 - 9.2e-29 100.3 0.0 1.2e-28 99.9 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF35836.1 - 2.2e-18 66.7 0.0 3.7e-18 65.9 0.0 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF35836.1 - 8.6e-10 38.8 0.0 1.3e-09 38.3 0.0 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 CCF35836.1 - 0.013 14.7 0.0 0.018 14.2 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Glyco_tran_WecB PF03808.13 CCF35836.1 - 0.021 14.8 0.0 0.04 13.9 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase WecB/TagA/CpsF family TrbI PF03743.14 CCF35836.1 - 0.057 13.2 0.0 6.5 6.5 0.0 2.2 2 0 0 2 2 2 0 Bacterial conjugation TrbI-like protein Shikimate_DH PF01488.20 CCF35836.1 - 0.15 12.2 0.0 0.26 11.4 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Epimerase PF01370.21 CCF35836.1 - 0.17 11.3 0.0 0.31 10.4 0.0 1.6 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family WD40 PF00400.32 CCF35838.1 - 2.1e-28 98.0 20.6 1.9e-05 25.3 0.0 6.3 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF35838.1 - 1.1e-12 48.1 0.0 0.34 11.3 0.0 5.2 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CCF35838.1 - 0.0064 16.4 0.0 2 8.3 0.0 3.1 1 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 CCF35838.1 - 0.03 13.3 0.3 9.3 5.1 0.0 3.4 1 1 4 5 5 5 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Frtz PF11768.8 CCF35838.1 - 0.075 11.3 0.0 0.14 10.4 0.0 1.5 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz MBOAT PF03062.19 CCF35839.1 - 2.7e-17 63.2 17.7 3.6e-17 62.8 17.7 1.3 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.6 CCF35839.1 - 0.0065 16.7 1.1 0.018 15.3 1.1 1.8 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family ICMT PF04140.14 CCF35840.1 - 4.9e-28 97.4 0.8 4.9e-28 97.4 0.8 1.7 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 CCF35840.1 - 1e-12 48.3 2.2 1e-12 48.3 2.2 2.1 2 1 0 2 2 2 1 Phospholipid methyltransferase DUF1295 PF06966.12 CCF35840.1 - 5.4e-05 22.8 0.7 0.0001 21.9 0.7 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) NnrU PF07298.11 CCF35840.1 - 0.0095 15.5 15.6 0.0096 15.4 13.9 1.8 1 1 1 2 2 2 1 NnrU protein Cyclin_N PF00134.23 CCF35841.1 - 9.8e-14 51.2 0.0 1.7e-13 50.5 0.0 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 CCF35841.1 - 1.7e-07 31.7 0.2 8e-07 29.6 0.2 2.1 1 1 0 1 1 1 1 Cyclin NAD_binding_2 PF03446.15 CCF35843.1 - 2.8e-33 115.3 0.0 3.4e-33 115.0 0.0 1.1 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.19 CCF35843.1 - 7.2e-05 22.2 0.0 9.5e-05 21.8 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.17 CCF35843.1 - 0.0013 19.3 0.0 0.0022 18.6 0.0 1.3 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_11 PF14833.6 CCF35843.1 - 0.0056 16.9 0.1 0.0085 16.3 0.1 1.3 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase TAP35_44 PF07265.11 CCF35843.1 - 0.053 13.5 0.4 0.16 12.0 0.2 1.7 1 1 1 2 2 2 0 Tapetum specific protein TAP35/TAP44 Sacchrp_dh_NADP PF03435.18 CCF35843.1 - 0.083 13.2 0.0 0.23 11.7 0.0 1.8 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain ApbA PF02558.16 CCF35843.1 - 0.099 12.3 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Beta-lactamase PF00144.24 CCF35844.1 - 5.3e-63 213.3 0.1 6.4e-63 213.0 0.1 1.0 1 0 0 1 1 1 1 Beta-lactamase PLDc_3 PF13918.6 CCF35844.1 - 0.005 16.5 0.1 0.0085 15.8 0.1 1.3 1 0 0 1 1 1 1 PLD-like domain Hemerythrin PF01814.23 CCF35845.1 - 5.8e-09 36.7 0.1 7.9e-09 36.2 0.1 1.2 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain His_biosynth PF00977.21 CCF35846.1 - 4.3e-36 124.5 0.0 5.2e-36 124.2 0.0 1.0 1 0 0 1 1 1 1 Histidine biosynthesis protein Ribul_P_3_epim PF00834.19 CCF35846.1 - 0.044 13.2 0.0 0.063 12.6 0.0 1.2 1 0 0 1 1 1 0 Ribulose-phosphate 3 epimerase family DUF4568 PF15132.6 CCF35847.1 - 0.089 12.2 0.0 0.12 11.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4568) MFS_1 PF07690.16 CCF35848.1 - 5.7e-24 84.7 26.9 5.7e-24 84.7 26.9 2.8 1 1 1 2 2 2 2 Major Facilitator Superfamily Adeno_E3B PF03376.14 CCF35848.1 - 4.2 7.7 8.5 1.2 9.4 0.9 3.1 2 1 1 3 3 3 0 Adenovirus E3B protein RhoGAP PF00620.27 CCF35849.1 - 3.2e-06 27.1 0.1 3.9e-06 26.8 0.1 1.1 1 0 0 1 1 1 1 RhoGAP domain Peptidase_M14 PF00246.24 CCF35850.1 - 7.6e-36 124.4 0.7 1.1e-35 123.9 0.7 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase ThuA PF06283.11 CCF35851.1 - 3.1e-60 204.0 0.2 8.9e-60 202.5 0.2 1.6 1 1 0 1 1 1 1 Trehalose utilisation DUF4159 PF13709.6 CCF35851.1 - 0.036 13.5 0.0 0.054 12.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4159) LBP_M PF17385.2 CCF35851.1 - 0.079 12.5 0.1 0.23 11.0 0.1 1.8 1 1 0 1 1 1 0 Lacto-N-biose phosphorylase central domain PLDc_2 PF13091.6 CCF35852.1 - 2.6e-18 66.2 0.0 4.5e-13 49.2 0.0 2.8 2 1 0 2 2 2 2 PLD-like domain PLDc PF00614.22 CCF35852.1 - 0.0068 16.6 0.1 0.94 9.8 0.0 2.4 2 0 0 2 2 2 2 Phospholipase D Active site motif Regulator_TrmB PF11495.8 CCF35852.1 - 0.11 11.6 0.2 13 4.9 0.0 2.7 3 0 0 3 3 3 0 Archaeal transcriptional regulator TrmB Sulfate_transp PF00916.20 CCF35853.1 - 4.1e-87 292.4 19.3 6.9e-87 291.7 19.3 1.4 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 CCF35853.1 - 1.8e-11 43.7 0.0 3.3e-11 42.9 0.0 1.4 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.6 CCF35853.1 - 0.061 13.7 0.1 0.24 11.8 0.0 2.0 2 0 0 2 2 2 0 STAS domain Cupin_1 PF00190.22 CCF35854.1 - 1.9e-41 141.2 0.0 1.4e-20 73.5 0.0 2.1 2 0 0 2 2 2 2 Cupin Cupin_2 PF07883.11 CCF35854.1 - 1.5e-26 91.9 1.1 1.7e-13 50.0 0.2 2.5 2 0 0 2 2 2 2 Cupin domain Cupin_3 PF05899.12 CCF35854.1 - 3.6e-08 33.0 0.1 0.0026 17.4 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF861) AraC_binding PF02311.19 CCF35854.1 - 4.8e-07 29.8 0.2 0.0012 18.7 0.1 2.3 2 0 0 2 2 2 2 AraC-like ligand binding domain MannoseP_isomer PF01050.18 CCF35854.1 - 0.0004 20.3 0.0 0.056 13.3 0.0 2.2 2 0 0 2 2 2 2 Mannose-6-phosphate isomerase ARD PF03079.14 CCF35854.1 - 0.0088 16.2 0.3 3.6 7.7 0.1 2.3 2 0 0 2 2 2 2 ARD/ARD' family 3-HAO PF06052.12 CCF35854.1 - 0.047 13.3 0.0 0.75 9.4 0.0 2.2 2 0 0 2 2 2 0 3-hydroxyanthranilic acid dioxygenase Pneumo_att_G PF05539.11 CCF35855.1 - 0.44 10.1 15.2 0.6 9.7 15.2 1.2 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G Miga PF10265.9 CCF35855.1 - 1.1 8.1 6.7 1.2 8.0 6.7 1.1 1 0 0 1 1 1 0 Mitoguardin Apt1 PF10351.9 CCF35855.1 - 7 5.4 9.0 7.9 5.2 9.0 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF3774 PF12609.8 CCF35856.1 - 0.027 15.5 0.4 0.034 15.2 0.4 1.2 1 0 0 1 1 1 0 Wound-induced protein Prp19 PF08606.11 CCF35856.1 - 0.11 12.5 0.0 0.43 10.6 0.0 1.8 2 0 0 2 2 2 0 Prp19/Pso4-like adh_short PF00106.25 CCF35857.1 - 3.7e-33 114.6 0.3 5e-33 114.2 0.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF35857.1 - 5.5e-24 85.0 1.3 1.4e-22 80.4 1.3 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF35857.1 - 2.1e-05 24.5 0.2 3.1e-05 23.9 0.2 1.4 1 0 0 1 1 1 1 KR domain Shikimate_DH PF01488.20 CCF35857.1 - 0.015 15.3 0.0 0.025 14.6 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Polysacc_synt_2 PF02719.15 CCF35857.1 - 0.022 13.9 0.0 0.03 13.4 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Epimerase PF01370.21 CCF35857.1 - 0.1 12.0 0.2 0.25 10.8 0.2 1.6 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family p450 PF00067.22 CCF35858.1 - 4.5e-71 240.0 0.0 5.3e-71 239.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Cyt-b5 PF00173.28 CCF35859.1 - 0.006 16.7 0.0 0.0072 16.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Fer2 PF00111.27 CCF35860.1 - 0.042 13.8 0.5 0.082 12.9 0.5 1.6 1 0 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain Arrestin_N PF00339.29 CCF35861.1 - 1.2e-16 61.1 0.0 1.8e-16 60.5 0.0 1.3 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 CCF35861.1 - 2.6e-16 60.3 0.0 1.6e-15 57.7 0.0 2.0 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain LDB19 PF13002.7 CCF35861.1 - 0.00046 20.0 0.0 0.00086 19.0 0.0 1.5 1 0 0 1 1 1 1 Arrestin_N terminal like Sarcoglycan_2 PF05510.13 CCF35861.1 - 0.023 13.5 0.0 0.071 11.9 0.0 1.7 2 0 0 2 2 2 0 Sarcoglycan alpha/epsilon zf-H2C2_2 PF13465.6 CCF35864.1 - 0.0091 16.4 2.5 0.71 10.4 0.3 2.3 2 0 0 2 2 2 2 Zinc-finger double domain FOXP-CC PF16159.5 CCF35864.1 - 0.044 14.4 0.1 0.083 13.5 0.0 1.5 1 1 1 2 2 2 0 FOXP coiled-coil domain Ribosomal_S6e PF01092.19 CCF35864.1 - 0.085 12.8 0.3 0.087 12.8 0.3 1.2 1 0 0 1 1 1 0 Ribosomal protein S6e zf-C2H2 PF00096.26 CCF35864.1 - 0.16 12.5 12.4 0.29 11.7 5.1 2.6 2 1 0 2 2 2 0 Zinc finger, C2H2 type TauD PF02668.16 CCF35865.1 - 3.1e-17 63.2 0.1 3.7e-17 63.0 0.1 1.0 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Epimerase PF01370.21 CCF35866.1 - 2e-09 37.3 0.0 2.6e-09 36.9 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CCF35866.1 - 0.00096 18.6 0.0 0.0013 18.2 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 CCF35866.1 - 0.0048 16.1 0.0 1.4 8.0 0.0 2.4 2 0 0 2 2 2 2 Male sterility protein HhH-GPD PF00730.25 CCF35867.1 - 0.01 16.3 0.0 0.019 15.4 0.0 1.5 1 1 0 1 1 1 0 HhH-GPD superfamily base excision DNA repair protein DUF4352 PF11611.8 CCF35868.1 - 0.024 14.9 0.6 0.11 12.8 0.2 2.0 1 1 0 2 2 2 0 Domain of unknown function (DUF4352) Cupredoxin_1 PF13473.6 CCF35868.1 - 0.031 14.4 1.1 1.5 8.9 0.0 2.5 2 1 1 3 3 3 0 Cupredoxin-like domain DUF1191 PF06697.12 CCF35868.1 - 0.15 11.8 0.1 0.31 10.8 0.0 1.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1191) PepSY_2 PF13670.6 CCF35868.1 - 0.41 10.7 2.4 4.9 7.2 0.6 2.9 2 1 0 2 2 2 0 Peptidase propeptide and YPEB domain ADH_zinc_N PF00107.26 CCF35870.1 - 1.1e-10 41.6 0.0 1.9e-10 40.8 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCF35870.1 - 0.0028 17.5 0.2 0.012 15.5 0.2 1.9 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain MCM PF00493.23 CCF35871.1 - 1.5e-80 269.5 0.2 2.1e-80 269.0 0.2 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_lid PF17855.1 CCF35871.1 - 2.1e-23 82.6 0.4 3.9e-23 81.7 0.4 1.5 1 0 0 1 1 1 1 MCM AAA-lid domain Mg_chelatase PF01078.21 CCF35871.1 - 1.2e-07 31.4 0.0 2.2e-06 27.2 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 CCF35871.1 - 0.0021 17.9 0.0 0.0041 17.0 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 CCF35871.1 - 0.0093 15.7 0.0 0.024 14.3 0.0 1.6 2 0 0 2 2 2 1 Sigma-54 interaction domain Nrap_D3 PF17404.2 CCF35871.1 - 0.088 12.9 0.0 0.53 10.4 0.0 2.2 2 0 0 2 2 2 0 Nrap protein domain 3 PfkB PF00294.24 CCF35872.1 - 2.9e-15 56.3 0.1 4.9e-09 35.9 0.8 2.1 2 0 0 2 2 2 2 pfkB family carbohydrate kinase HEPN_DZIP3 PF18738.1 CCF35873.1 - 0.0091 15.8 0.0 0.013 15.2 0.0 1.2 1 0 0 1 1 1 1 DZIP3/ hRUL138-like HEPN CAP_N PF01213.19 CCF35874.1 - 5.5e-65 219.9 0.1 6.2e-65 219.8 0.1 1.0 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal Med21 PF11221.8 CCF35874.1 - 0.024 14.9 0.3 0.046 14.0 0.3 1.5 1 1 0 1 1 1 0 Subunit 21 of Mediator complex DEC-1_N PF04625.13 CCF35874.1 - 0.14 11.2 6.8 0.16 11.0 6.8 1.1 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region PARP PF00644.20 CCF35875.1 - 1.5e-14 54.1 0.3 3.8e-14 52.8 0.2 1.6 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain UQ_con PF00179.26 CCF35875.1 - 2.9e-06 27.0 0.0 5.9e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RAP1 PF07218.11 CCF35876.1 - 0.85 7.8 1.8 0.97 7.6 1.8 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) EI24 PF07264.11 CCF35877.1 - 5.3e-13 49.6 5.1 9.7e-13 48.7 5.1 1.4 1 1 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) Retrotrans_gag PF03732.17 CCF35878.1 - 0.16 12.3 1.3 0.3 11.4 1.3 1.5 1 0 0 1 1 1 0 Retrotransposon gag protein Epimerase PF01370.21 CCF35879.1 - 4.8e-17 62.2 0.0 1.1e-16 61.1 0.0 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CCF35879.1 - 2.9e-12 46.2 0.0 4.1e-12 45.7 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 CCF35879.1 - 1.7e-11 44.1 0.0 3.2e-11 43.2 0.0 1.4 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 CCF35879.1 - 4.3e-09 35.9 0.1 3.1e-07 29.8 0.1 2.1 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 CCF35879.1 - 1.2e-08 35.1 0.0 2.4e-08 34.1 0.0 1.5 1 0 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 CCF35879.1 - 3.4e-06 26.4 0.0 4.9e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein KR PF08659.10 CCF35879.1 - 0.00032 20.7 0.0 0.00066 19.6 0.0 1.5 1 0 0 1 1 1 1 KR domain NmrA PF05368.13 CCF35879.1 - 0.0088 15.6 0.2 0.045 13.3 0.1 2.2 1 1 0 1 1 1 1 NmrA-like family F420_oxidored PF03807.17 CCF35879.1 - 0.031 14.9 0.0 0.17 12.5 0.0 2.1 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent adh_short PF00106.25 CCF35879.1 - 0.081 12.4 0.1 0.17 11.3 0.1 1.7 1 1 0 1 1 1 0 short chain dehydrogenase DUF3425 PF11905.8 CCF35880.1 - 5.3e-17 61.9 0.3 9.6e-17 61.1 0.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) His_Phos_2 PF00328.22 CCF35881.1 - 1.3e-14 54.4 0.0 1.9e-14 53.9 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Crust_neuro_H PF03858.13 CCF35881.1 - 0.0017 19.1 0.1 0.0033 18.2 0.1 1.5 1 0 0 1 1 1 1 Crustacean neurohormone H Fungal_trans PF04082.18 CCF35882.1 - 3.6e-20 72.1 0.3 5.6e-20 71.5 0.3 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF35882.1 - 1.6e-07 31.4 9.0 3.2e-07 30.3 9.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Abhydrolase_6 PF12697.7 CCF35883.1 - 0.0022 18.7 0.7 0.0029 18.3 0.3 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Gryzun PF07919.12 CCF35884.1 - 2.6e-243 809.1 0.0 3.2e-243 808.9 0.0 1.1 1 0 0 1 1 1 1 Gryzun, putative trafficking through Golgi Foie-gras_1 PF11817.8 CCF35884.1 - 2.6e-93 312.4 5.4 2.4e-88 296.1 4.6 2.2 2 0 0 2 2 2 2 Foie gras liver health family 1 Gryzun-like PF12742.7 CCF35884.1 - 0.0037 17.2 0.0 0.0074 16.3 0.0 1.5 1 0 0 1 1 1 1 Gryzun, putative Golgi trafficking RXT2_N PF08595.11 CCF35885.1 - 1.4e-11 44.7 1.7 2.8e-11 43.7 0.2 2.1 2 1 0 2 2 2 1 RXT2-like, N-terminal HpcH_HpaI PF03328.14 CCF35886.1 - 4.3e-28 98.0 0.0 5.6e-28 97.6 0.0 1.1 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family PK PF00224.21 CCF35886.1 - 0.01 14.8 0.2 0.014 14.3 0.2 1.2 1 0 0 1 1 1 0 Pyruvate kinase, barrel domain Usp PF00582.26 CCF35886.1 - 0.11 13.0 0.0 0.16 12.5 0.0 1.2 1 0 0 1 1 1 0 Universal stress protein family Fungal_trans PF04082.18 CCF35888.1 - 3.6e-20 72.1 0.1 6e-19 68.1 0.1 2.2 2 0 0 2 2 2 2 Fungal specific transcription factor domain Not3 PF04065.15 CCF35889.1 - 0.0018 17.7 0.7 0.0019 17.7 0.7 1.1 1 0 0 1 1 1 1 Not1 N-terminal domain, CCR4-Not complex component GAS PF13851.6 CCF35889.1 - 0.0086 15.4 2.9 0.012 15.0 2.9 1.1 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding Fzo_mitofusin PF04799.13 CCF35889.1 - 0.0087 15.6 0.8 0.01 15.4 0.8 1.1 1 0 0 1 1 1 1 fzo-like conserved region Helo_like_N PF17111.5 CCF35889.1 - 0.0088 15.4 2.0 0.07 12.5 0.3 2.0 1 1 1 2 2 2 2 Fungal N-terminal domain of STAND proteins TT_ORF2 PF02957.15 CCF35890.1 - 0.74 10.7 0.0 0.74 10.7 0.0 2.8 3 0 0 3 3 3 0 TT viral ORF2 LCE6A PF15858.5 CCF35892.1 - 0.41 11.4 9.5 0.75 10.6 9.5 1.5 1 0 0 1 1 1 0 Late cornified envelope protein 6A family DUF1720 PF08226.11 CCF35892.1 - 1 9.8 38.0 0.2 12.1 30.4 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF1720) TFIIA PF03153.13 CCF35892.1 - 1.3 8.9 15.2 1.4 8.9 15.2 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Fungal_trans PF04082.18 CCF35893.1 - 8.3e-23 80.8 0.0 1.4e-22 80.0 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF35893.1 - 4.6e-08 33.0 12.1 4.6e-08 33.0 12.1 2.9 3 0 0 3 3 3 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DNA_photolyase PF00875.18 CCF35894.1 - 1.4e-38 132.5 0.0 2.4e-38 131.7 0.0 1.3 1 0 0 1 1 1 1 DNA photolyase CactinC_cactus PF09732.9 CCF35895.1 - 4.2e-51 172.1 3.0 7.2e-51 171.4 3.0 1.3 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein Cactin_mid PF10312.9 CCF35895.1 - 5.7e-47 160.0 9.4 3.1e-26 92.3 0.8 2.2 1 1 1 2 2 2 2 Conserved mid region of cactin SF3A2 PF16835.5 CCF35895.1 - 0.0097 16.3 0.0 0.024 15.0 0.0 1.6 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) EthD PF07110.11 CCF35895.1 - 0.17 13.0 1.1 0.6 11.3 0.2 2.4 2 0 0 2 2 2 0 EthD domain Pro_Al_protease PF02983.14 CCF35897.1 - 0.26 11.4 2.0 3.6 7.7 0.1 2.4 2 0 0 2 2 2 0 Alpha-lytic protease prodomain WD40 PF00400.32 CCF35898.1 - 1.8e-07 31.8 13.1 0.00013 22.7 0.5 4.2 4 1 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF35898.1 - 0.008 16.5 0.1 0.11 12.8 0.1 2.6 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 CCF35898.1 - 0.02 13.5 0.0 0.024 13.2 0.0 1.1 1 0 0 1 1 1 0 Cytochrome D1 heme domain FOXP-CC PF16159.5 CCF35899.1 - 0.02 15.5 3.9 0.27 11.9 0.2 2.3 2 0 0 2 2 2 0 FOXP coiled-coil domain zf-C2H2 PF00096.26 CCF35899.1 - 0.59 10.7 3.5 2.1 8.9 0.1 3.0 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCF35899.1 - 2.1 9.4 5.4 28 5.9 0.5 2.9 3 0 0 3 3 3 0 C2H2-type zinc finger adh_short PF00106.25 CCF35900.1 - 6.7e-25 87.7 0.0 2.1e-24 86.1 0.0 1.6 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF35900.1 - 3e-22 79.3 0.0 3.7e-22 79.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF35900.1 - 0.00021 21.2 0.0 0.0003 20.8 0.0 1.4 1 1 0 1 1 1 1 KR domain CoA_binding_2 PF13380.6 CCF35900.1 - 0.12 12.9 0.0 0.2 12.1 0.0 1.3 1 0 0 1 1 1 0 CoA binding domain DFRP_C PF16543.5 CCF35901.1 - 2.4e-26 92.0 8.3 2.4e-26 92.0 8.3 3.6 3 1 0 3 3 3 1 DRG Family Regulatory Proteins, Tma46 Torus PF16131.5 CCF35901.1 - 5.2e-07 30.3 15.5 6.5e-07 30.0 2.2 3.5 2 1 1 3 3 3 2 Torus domain zf-CCCH PF00642.24 CCF35901.1 - 3.7e-06 26.7 8.4 1.2e-05 25.1 1.2 2.9 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 CCF35901.1 - 2.9e-05 23.7 10.3 0.0026 17.5 2.7 3.3 3 0 0 3 3 3 2 CCCH-type zinc finger zf_CCCH_4 PF18345.1 CCF35901.1 - 0.00013 21.9 6.7 0.00013 21.9 6.7 3.2 3 0 0 3 3 3 2 Zinc finger domain zf-CCCH_3 PF15663.5 CCF35901.1 - 0.017 15.3 4.2 0.53 10.5 2.4 2.8 2 1 0 2 2 2 0 Zinc-finger containing family zf-CCCH_2 PF14608.6 CCF35901.1 - 0.4 11.2 16.1 0.35 11.4 6.7 2.9 2 1 0 2 2 2 0 RNA-binding, Nab2-type zinc finger Ost4 PF10215.9 CCF35902.1 - 3e-20 71.7 0.3 3.4e-20 71.6 0.3 1.1 1 0 0 1 1 1 1 Oligosaccaryltransferase RRM_1 PF00076.22 CCF35903.1 - 3e-15 55.8 0.0 4.7e-15 55.2 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.6 CCF35903.1 - 0.00015 22.3 3.1 0.00015 22.3 3.1 2.8 2 1 1 3 3 3 1 C-terminal duplication domain of Friend of PRMT1 RRM_occluded PF16842.5 CCF35903.1 - 0.017 15.0 0.0 0.03 14.2 0.0 1.4 1 0 0 1 1 1 0 Occluded RNA-recognition motif CS PF04969.16 CCF35904.1 - 1e-08 36.1 0.0 1.6e-08 35.4 0.0 1.3 1 0 0 1 1 1 1 CS domain Snf7 PF03357.21 CCF35905.1 - 2.2e-24 86.0 12.6 2.2e-24 86.0 12.6 2.0 2 0 0 2 2 2 1 Snf7 TPR_MLP1_2 PF07926.12 CCF35905.1 - 0.78 9.8 15.5 0.18 11.8 8.2 2.5 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein Fib_alpha PF08702.10 CCF35905.1 - 1.3 9.3 8.1 0.59 10.3 5.6 1.7 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Acetyltransf_6 PF13480.7 CCF35905.1 - 4.3 7.5 5.7 22 5.2 1.9 2.2 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain PWWP PF00855.17 CCF35906.1 - 7.5e-16 58.3 0.0 7.5e-16 58.3 0.0 3.5 1 1 1 2 2 2 1 PWWP domain Sec63 PF02889.16 CCF35907.1 - 3.4e-155 514.7 0.2 5.5e-82 274.8 0.0 2.1 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 CCF35907.1 - 3.2e-19 69.4 0.0 9.8e-19 67.8 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 CCF35907.1 - 2e-08 34.4 0.0 4e-08 33.4 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 CCF35907.1 - 0.11 12.8 0.0 0.94 9.7 0.0 2.5 1 1 0 1 1 1 0 AAA domain WD40 PF00400.32 CCF35908.1 - 3.7e-41 138.3 18.6 1.4e-05 25.7 0.0 8.0 7 0 0 7 7 7 7 WD domain, G-beta repeat F-box PF00646.33 CCF35908.1 - 1.1e-10 41.0 0.8 5.8e-10 38.8 0.3 2.3 2 1 0 2 2 2 1 F-box domain F-box-like PF12937.7 CCF35908.1 - 2.5e-10 40.1 0.1 5.3e-10 39.0 0.1 1.6 1 0 0 1 1 1 1 F-box-like ANAPC4_WD40 PF12894.7 CCF35908.1 - 6.4e-08 32.8 1.8 2.1 8.7 0.0 5.9 3 2 4 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 CCF35908.1 - 0.0026 17.4 0.5 0.48 10.0 0.0 2.8 2 1 0 2 2 2 1 PQQ-like domain F-box_4 PF15966.5 CCF35908.1 - 0.0041 17.0 0.0 0.011 15.6 0.0 1.7 1 0 0 1 1 1 1 F-box DUF4597 PF15366.6 CCF35908.1 - 0.053 13.3 1.0 0.75 9.6 0.1 3.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4597) Nup160 PF11715.8 CCF35908.1 - 0.081 11.5 4.5 40 2.7 0.0 4.6 3 1 2 5 5 5 0 Nucleoporin Nup120/160 ABC2_membrane PF01061.24 CCF35910.1 - 9e-77 257.2 60.3 9.6e-40 136.2 25.5 2.7 3 0 0 3 3 3 2 ABC-2 type transporter ABC_tran PF00005.27 CCF35910.1 - 1.9e-35 122.3 0.0 3.6e-16 59.9 0.0 2.6 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 CCF35910.1 - 9.2e-27 92.8 2.0 7.3e-23 80.3 0.0 3.3 3 0 0 3 3 2 2 CDR ABC transporter ABC_trans_N PF14510.6 CCF35910.1 - 4.7e-19 68.8 0.4 5.3e-18 65.4 0.1 2.9 2 0 0 2 2 2 1 ABC-transporter N-terminal AAA_16 PF13191.6 CCF35910.1 - 6.9e-06 26.6 0.4 0.036 14.4 0.0 2.9 3 0 0 3 3 3 2 AAA ATPase domain AAA_33 PF13671.6 CCF35910.1 - 8.7e-06 26.0 0.0 0.0054 16.9 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_21 PF13304.6 CCF35910.1 - 8.8e-06 25.7 0.0 0.19 11.5 0.0 2.8 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CCF35910.1 - 2.1e-05 24.2 0.1 0.012 15.3 0.0 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_18 PF13238.6 CCF35910.1 - 2.5e-05 24.8 0.0 0.015 15.9 0.0 2.7 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 CCF35910.1 - 0.00019 21.4 0.0 0.0038 17.2 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase ABC2_membrane_3 PF12698.7 CCF35910.1 - 0.00027 20.1 13.2 0.00027 20.1 13.2 3.2 2 1 0 3 3 2 2 ABC-2 family transporter protein AAA_17 PF13207.6 CCF35910.1 - 0.00035 21.0 0.0 0.032 14.6 0.0 2.6 2 0 0 2 2 2 1 AAA domain SMC_N PF02463.19 CCF35910.1 - 0.0011 18.4 0.0 0.71 9.3 0.0 3.5 3 1 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_25 PF13481.6 CCF35910.1 - 0.0011 18.5 0.1 0.014 15.0 0.1 2.4 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 CCF35910.1 - 0.0022 18.3 0.0 0.34 11.2 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 CCF35910.1 - 0.0027 18.0 1.2 0.055 13.7 0.0 3.1 3 0 0 3 3 3 1 AAA domain NACHT PF05729.12 CCF35910.1 - 0.018 15.0 0.8 6.3 6.7 0.1 2.4 2 0 0 2 2 2 0 NACHT domain AAA_30 PF13604.6 CCF35910.1 - 0.053 13.2 0.4 1.8 8.2 0.1 2.4 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 CCF35910.1 - 0.087 13.3 0.2 0.43 11.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 CCF35910.1 - 0.11 12.1 1.4 0.34 10.5 0.3 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain SUI1 PF01253.22 CCF35911.1 - 1.3e-25 89.7 0.5 1.3e-25 89.7 0.5 1.9 2 0 0 2 2 2 1 Translation initiation factor SUI1 TnpV PF14198.6 CCF35911.1 - 0.049 13.6 0.1 0.085 12.8 0.1 1.3 1 0 0 1 1 1 0 Transposon-encoded protein TnpV Nbl1_Borealin_N PF10444.9 CCF35912.1 - 3.1e-19 68.4 6.3 4.7e-19 67.8 6.3 1.3 1 0 0 1 1 1 1 Nbl1 / Borealin N terminal VWA_2 PF13519.6 CCF35913.1 - 3.4e-27 95.2 0.0 7.7e-27 94.1 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 CCF35913.1 - 9.9e-11 42.2 0.6 1.3e-10 41.8 0.6 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain Ssl1 PF04056.14 CCF35913.1 - 2.5e-07 30.7 0.0 3.5e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 Ssl1-like UIM PF02809.20 CCF35913.1 - 0.021 14.7 0.8 0.057 13.4 0.8 1.8 1 0 0 1 1 1 0 Ubiquitin interaction motif Sybindin PF04099.12 CCF35914.1 - 1.1e-52 177.8 0.0 1.3e-52 177.5 0.0 1.1 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.13 CCF35914.1 - 9.8e-08 32.2 0.1 1.6e-07 31.5 0.1 1.3 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region IBN_N PF03810.19 CCF35915.1 - 2e-10 40.4 0.1 1.6e-09 37.5 0.1 2.6 2 0 0 2 2 2 1 Importin-beta N-terminal domain Xpo1 PF08389.12 CCF35915.1 - 0.0092 16.0 0.0 16 5.5 0.0 4.2 4 0 0 4 4 4 1 Exportin 1-like protein CAS_CSE1 PF03378.15 CCF35915.1 - 0.02 13.4 0.0 0.044 12.3 0.0 1.4 1 0 0 1 1 1 0 CAS/CSE protein, C-terminus PatG_C PF18065.1 CCF35915.1 - 0.1 12.6 0.0 16 5.5 0.0 2.5 2 0 0 2 2 2 0 PatG C-terminal DUF1479 PF07350.12 CCF35917.1 - 0.095 11.4 0.0 0.11 11.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1479) DUF3085 PF11284.8 CCF35918.1 - 0.13 12.5 0.0 0.2 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3085) BBE PF08031.12 CCF35920.1 - 5.3e-13 48.8 0.0 1.1e-12 47.9 0.0 1.6 1 0 0 1 1 1 1 Berberine and berberine like FAD_binding_4 PF01565.23 CCF35920.1 - 1.3e-07 31.4 0.0 0.00053 19.7 0.0 2.9 2 1 1 3 3 3 2 FAD binding domain Cytokin-bind PF09265.10 CCF35920.1 - 0.14 11.6 0.0 0.22 10.9 0.0 1.2 1 0 0 1 1 1 0 Cytokinin dehydrogenase 1, FAD and cytokinin binding Glyco_hydro_43 PF04616.14 CCF35921.1 - 7.4e-105 350.4 0.3 7.4e-105 350.4 0.3 1.4 2 0 0 2 2 2 1 Glycosyl hydrolases family 43 GH43_C2 PF17851.1 CCF35921.1 - 5e-27 94.9 0.0 8.2e-27 94.2 0.0 1.3 1 0 0 1 1 1 1 Beta xylosidase C-terminal Concanavalin A-like domain Glyco_hydro_32N PF00251.20 CCF35921.1 - 0.031 13.8 0.1 0.074 12.6 0.1 1.6 1 1 0 1 1 1 0 Glycosyl hydrolases family 32 N-terminal domain Ada3 PF10198.9 CCF35922.1 - 4.2e-56 188.7 6.5 5.3e-56 188.4 0.1 2.9 2 1 0 2 2 2 1 Histone acetyltransferases subunit 3 Diacid_rec PF05651.13 CCF35922.1 - 0.097 12.3 0.1 0.19 11.4 0.1 1.4 1 0 0 1 1 1 0 Putative sugar diacid recognition LRIF1 PF15741.5 CCF35922.1 - 0.3 9.6 6.9 0.42 9.1 6.9 1.2 1 0 0 1 1 1 0 Ligand-dependent nuclear receptor-interacting factor 1 zf-C2H2_2 PF12756.7 CCF35923.1 - 0.047 14.0 0.0 0.069 13.5 0.0 1.3 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) DUF188 PF02639.14 CCF35923.1 - 0.17 11.6 0.1 0.35 10.5 0.0 1.6 2 0 0 2 2 2 0 Uncharacterized BCR, YaiI/YqxD family COG1671 zf-C2H2_jaz PF12171.8 CCF35923.1 - 1.2 9.5 3.7 4.8 7.6 3.7 1.9 1 1 0 1 1 1 0 Zinc-finger double-stranded RNA-binding Prenyltrans PF00432.21 CCF35924.1 - 2.2e-56 187.3 8.6 1.4e-11 43.9 0.0 6.1 6 0 0 6 6 6 6 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_N PF13249.6 CCF35924.1 - 0.00024 20.3 0.0 0.27 10.3 0.0 3.6 2 1 2 4 4 4 2 Squalene-hopene cyclase N-terminal domain PUF PF00806.19 CCF35926.1 - 0.017 14.8 0.0 0.028 14.1 0.0 1.4 1 0 0 1 1 1 0 Pumilio-family RNA binding repeat Aspzincin_M35 PF14521.6 CCF35927.1 - 1.4e-11 45.1 0.3 1.2e-10 42.1 0.1 2.3 2 1 0 2 2 2 1 Lysine-specific metallo-endopeptidase Peptidase_M35 PF02102.15 CCF35927.1 - 0.00084 18.3 0.0 0.0012 17.8 0.0 1.2 1 0 0 1 1 1 1 Deuterolysin metalloprotease (M35) family MFS_1 PF07690.16 CCF35930.1 - 4.5e-32 111.3 22.3 4.5e-32 111.3 22.3 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Ribosomal_S7 PF00177.21 CCF35932.1 - 0.011 15.4 0.9 0.018 14.7 0.9 1.2 1 0 0 1 1 1 0 Ribosomal protein S7p/S5e LAP1C PF05609.12 CCF35932.1 - 2.4 7.2 14.2 3.2 6.7 14.2 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Peptidase_S49_N PF08496.10 CCF35933.1 - 0.29 11.2 6.5 0.57 10.2 6.5 1.5 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Coatomer_E PF04733.14 CCF35934.1 - 2.4e-62 211.0 6.1 2.7e-62 210.8 6.1 1.0 1 0 0 1 1 1 1 Coatomer epsilon subunit TPR_19 PF14559.6 CCF35934.1 - 1.8e-07 31.5 22.0 0.0061 17.0 6.0 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 CCF35934.1 - 4.1e-07 30.1 0.1 0.32 11.2 0.0 3.3 3 0 0 3 3 3 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 CCF35934.1 - 0.00074 19.8 14.0 0.16 12.3 2.4 5.0 4 2 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 CCF35934.1 - 0.0019 18.3 0.9 5.5 7.5 0.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 CCF35934.1 - 0.0045 17.7 16.9 0.35 11.8 3.1 5.7 4 3 1 5 5 5 1 Tetratricopeptide repeat TPR_1 PF00515.28 CCF35934.1 - 0.011 15.5 3.7 2.4 8.1 0.1 4.5 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_4 PF07721.14 CCF35934.1 - 0.029 15.0 3.3 0.1 13.3 1.3 5.1 7 0 0 7 7 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 CCF35934.1 - 0.036 14.7 5.0 9 7.2 0.2 4.7 4 0 0 4 4 4 0 Tetratricopeptide repeat Type_III_YscG PF09477.10 CCF35934.1 - 0.082 13.0 3.1 0.85 9.7 0.1 3.2 1 1 1 3 3 3 0 Bacterial type II secretion system chaperone protein (type_III_yscG) TPR_2 PF07719.17 CCF35934.1 - 0.13 12.4 0.4 0.13 12.4 0.4 5.5 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_7 PF13176.6 CCF35934.1 - 0.5 10.5 8.5 62 4.0 0.0 5.3 6 1 1 7 7 7 0 Tetratricopeptide repeat TPR_16 PF13432.6 CCF35934.1 - 2.3 8.9 17.8 2.2 9.0 2.4 4.3 4 2 1 5 5 5 0 Tetratricopeptide repeat Ferritin_2 PF13668.6 CCF35935.1 - 6.8e-40 136.4 0.6 1e-39 135.9 0.6 1.3 1 0 0 1 1 1 1 Ferritin-like domain Phage_CII PF05269.11 CCF35936.1 - 0.16 12.2 0.0 0.34 11.2 0.0 1.5 1 0 0 1 1 1 0 Bacteriophage CII protein Epimerase PF01370.21 CCF35937.1 - 7.3e-11 42.0 0.0 1.3e-10 41.2 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CCF35937.1 - 1.1e-07 31.9 0.4 4.5e-07 29.9 0.1 2.0 2 0 0 2 2 2 1 NAD(P)H-binding 3Beta_HSD PF01073.19 CCF35937.1 - 1.1e-05 24.6 0.0 4e-05 22.7 0.0 1.7 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short PF00106.25 CCF35937.1 - 0.00018 21.1 0.1 0.05 13.0 0.0 2.4 2 0 0 2 2 2 2 short chain dehydrogenase GDP_Man_Dehyd PF16363.5 CCF35937.1 - 0.00079 18.9 0.0 0.0011 18.4 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 CCF35937.1 - 0.0009 18.5 0.0 0.0015 17.8 0.0 1.6 1 1 0 1 1 1 1 Male sterility protein Polysacc_synt_2 PF02719.15 CCF35937.1 - 0.021 13.9 0.0 0.037 13.2 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein NmrA PF05368.13 CCF35937.1 - 0.095 12.2 0.1 0.24 10.9 0.1 1.8 1 1 0 1 1 1 0 NmrA-like family CENP-T_C PF15511.6 CCF35938.1 - 3.1e-30 104.5 0.0 5.7e-30 103.6 0.0 1.4 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 CCF35938.1 - 3.5e-08 33.7 0.0 6.7e-08 32.8 0.0 1.4 1 0 0 1 1 1 1 CENP-S protein Histone PF00125.24 CCF35938.1 - 4.1e-05 24.0 0.4 4.1e-05 24.0 0.4 1.9 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CCF35938.1 - 0.00054 20.2 0.0 0.001 19.3 0.0 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone SURF1 PF02104.15 CCF35939.1 - 2.5e-06 27.9 0.0 2.8e-06 27.7 0.0 1.1 1 0 0 1 1 1 1 SURF1 family Ubiq_cyt_C_chap PF03981.12 CCF35940.1 - 7.3e-35 120.1 1.6 1.6e-34 119.0 1.6 1.5 1 0 0 1 1 1 1 Ubiquinol-cytochrome C chaperone DHFR_1 PF00186.19 CCF35941.1 - 8.9e-23 80.8 0.0 7.5e-22 77.8 0.0 2.4 1 1 1 2 2 2 1 Dihydrofolate reductase tRNA-synt_1 PF00133.22 CCF35944.1 - 7.8e-122 407.5 0.0 9.3e-122 407.3 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 CCF35944.1 - 2.8e-14 52.7 0.0 2.6e-10 39.6 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 CCF35944.1 - 0.15 11.6 0.0 0.23 11.0 0.0 1.2 1 0 0 1 1 1 0 Leucyl-tRNA synthetase, Domain 2 PRP9_N PF16958.5 CCF35945.1 - 0.0065 16.5 1.3 0.0065 16.5 1.3 1.9 2 0 0 2 2 2 1 Pre-mRNA-splicing factor PRP9 N-terminus Ferlin_C PF16165.5 CCF35945.1 - 0.051 13.5 4.6 0.57 10.1 1.2 2.5 2 0 0 2 2 2 0 Ferlin C-terminus Mitoc_L55 PF09776.9 CCF35945.1 - 1.9 8.2 7.3 0.098 12.4 0.6 2.2 2 0 0 2 2 2 0 Mitochondrial ribosomal protein L55 Abhydrolase_1 PF00561.20 CCF35947.1 - 7.2e-17 61.9 0.8 8.3e-16 58.4 0.8 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCF35947.1 - 3.7e-13 50.6 3.8 7.4e-13 49.6 3.8 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCF35947.1 - 5.9e-09 35.5 0.0 8.5e-09 35.0 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.14 CCF35947.1 - 0.0016 17.2 0.0 0.0023 16.7 0.0 1.1 1 0 0 1 1 1 1 Ndr family EHN PF06441.12 CCF35947.1 - 0.06 13.7 0.0 0.18 12.2 0.0 1.8 1 0 0 1 1 1 0 Epoxide hydrolase N terminus MMR_HSR1_Xtn PF16897.5 CCF35948.1 - 1.6e-37 127.8 0.6 3e-37 126.8 0.6 1.5 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain MMR_HSR1 PF01926.23 CCF35948.1 - 1.6e-21 76.5 0.1 1.6e-20 73.3 0.0 2.2 1 1 1 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CCF35948.1 - 4.7e-10 39.2 0.1 2.8e-09 36.7 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 CCF35948.1 - 7.8e-05 22.8 0.1 0.03 14.4 0.0 2.4 1 1 1 2 2 2 2 Dynamin family GTP_EFTU PF00009.27 CCF35948.1 - 0.0014 18.2 0.6 4 6.9 0.0 4.0 2 2 0 2 2 2 2 Elongation factor Tu GTP binding domain MeaB PF03308.16 CCF35948.1 - 0.0063 15.5 0.2 0.018 14.0 0.1 1.8 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AIG1 PF04548.16 CCF35948.1 - 0.013 14.9 0.0 0.019 14.3 0.0 1.2 1 0 0 1 1 1 0 AIG1 family Arf PF00025.21 CCF35948.1 - 0.035 13.5 0.3 8 5.9 0.0 2.3 2 0 0 2 2 2 0 ADP-ribosylation factor family RsgA_GTPase PF03193.16 CCF35948.1 - 0.068 13.1 2.1 2.8 7.8 0.3 2.9 2 2 0 2 2 2 0 RsgA GTPase Roc PF08477.13 CCF35948.1 - 0.096 12.9 0.2 3.6 7.8 0.0 2.3 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.6 CCF35948.1 - 0.11 12.8 0.1 0.78 10.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 CCF35948.1 - 0.18 12.2 0.0 0.66 10.3 0.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain p450 PF00067.22 CCF35951.1 - 4.7e-55 187.2 0.0 6e-55 186.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF4235 PF14019.6 CCF35951.1 - 0.24 11.5 0.7 0.46 10.6 0.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4235) FAD_binding_3 PF01494.19 CCF35952.1 - 1.2e-26 93.8 0.4 1.6e-25 90.1 0.4 2.1 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CCF35952.1 - 2.1e-06 27.2 0.7 0.00058 19.2 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCF35952.1 - 1e-05 25.3 0.1 2.5e-05 24.1 0.0 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 CCF35952.1 - 5.9e-05 22.3 1.8 0.00095 18.3 1.8 2.2 1 1 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_3 PF13738.6 CCF35952.1 - 0.00021 20.6 0.5 0.0056 16.0 0.5 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCF35952.1 - 0.00094 19.4 0.4 0.0026 18.0 0.4 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 CCF35952.1 - 0.0031 18.0 1.5 0.015 15.9 0.3 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 CCF35952.1 - 0.0036 16.7 1.2 0.14 11.4 0.1 2.2 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase GIDA PF01134.22 CCF35952.1 - 0.016 14.3 0.0 0.024 13.7 0.0 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A Trp_halogenase PF04820.14 CCF35952.1 - 0.028 13.3 0.8 0.11 11.3 0.1 2.0 1 1 1 2 2 2 0 Tryptophan halogenase FAD_binding_2 PF00890.24 CCF35952.1 - 0.037 13.1 0.8 0.11 11.5 0.4 2.0 2 0 0 2 2 2 0 FAD binding domain HI0933_like PF03486.14 CCF35952.1 - 0.09 11.5 0.5 2.2 6.9 0.1 2.1 2 0 0 2 2 2 0 HI0933-like protein Peptidase_M43 PF05572.13 CCF35953.1 - 1.4e-12 47.8 0.1 2.6e-12 46.9 0.1 1.4 1 0 0 1 1 1 1 Pregnancy-associated plasma protein-A Reprolysin_3 PF13582.6 CCF35953.1 - 0.0052 17.3 0.1 0.014 16.0 0.0 1.8 1 1 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 CCF35953.1 - 0.017 15.2 0.0 0.025 14.7 0.0 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12 RasGEF PF00617.19 CCF35954.1 - 2.8e-49 167.7 0.6 4.5e-49 167.0 0.6 1.3 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 CCF35954.1 - 2.8e-12 46.8 0.0 6.4e-12 45.6 0.0 1.6 1 0 0 1 1 1 1 RasGEF N-terminal motif Ribosomal_S2 PF00318.20 CCF35955.1 - 5.5e-27 94.4 0.1 4.5e-15 55.5 0.1 2.1 1 1 1 2 2 2 2 Ribosomal protein S2 40S_SA_C PF16122.5 CCF35955.1 - 1.7e-06 29.3 12.0 3e-06 28.5 12.0 1.4 1 0 0 1 1 1 1 40S ribosomal protein SA C-terminus Ribosomal_S15 PF00312.22 CCF35956.1 - 4.3e-23 81.3 0.5 4.3e-23 81.3 0.5 2.5 4 0 0 4 4 4 1 Ribosomal protein S15 Staphylokinase PF02821.16 CCF35956.1 - 0.032 14.7 0.1 0.084 13.3 0.1 1.8 1 0 0 1 1 1 0 Staphylokinase/Streptokinase family FlaG PF03646.15 CCF35956.1 - 0.081 13.1 0.5 0.081 13.1 0.5 2.4 2 0 0 2 2 2 0 FlaG protein ATP-synt_DE PF00401.20 CCF35956.1 - 4.3 7.7 11.8 0.34 11.2 1.1 2.6 2 0 0 2 2 2 0 ATP synthase, Delta/Epsilon chain, long alpha-helix domain vATP-synt_AC39 PF01992.16 CCF35957.1 - 3e-108 362.3 0.0 3.4e-108 362.1 0.0 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit NOP5NT PF08156.13 CCF35958.1 - 3e-20 72.4 0.8 4.9e-20 71.7 0.8 1.3 1 0 0 1 1 1 1 NOP5NT (NUC127) domain IMS PF00817.20 CCF35959.1 - 6.9e-40 136.5 0.0 1.2e-39 135.7 0.0 1.4 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 CCF35959.1 - 3.4e-14 53.6 0.0 7e-14 52.5 0.0 1.5 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain zf_UBZ PF18439.1 CCF35959.1 - 5.2e-13 48.3 3.3 1.1e-12 47.2 3.3 1.6 1 0 0 1 1 1 1 Ubiquitin-Binding Zinc Finger IMS_HHH PF11798.8 CCF35959.1 - 0.053 13.9 0.0 0.13 12.6 0.0 1.7 1 0 0 1 1 1 0 IMS family HHH motif zf-C2H2_4 PF13894.6 CCF35959.1 - 0.35 11.8 1.2 1.2 10.2 1.2 2.0 1 0 0 1 1 1 0 C2H2-type zinc finger zf_C2H2_6 PF18450.1 CCF35959.1 - 0.81 9.5 2.0 1.3 8.8 0.1 2.2 2 0 0 2 2 2 0 Zinc Finger domain Sugar_tr PF00083.24 CCF35961.1 - 4.2e-121 405.0 17.6 6.7e-121 404.3 17.6 1.3 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF35961.1 - 2.7e-28 98.9 47.2 2.9e-24 85.7 25.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Ni_hydr_CYTB PF01292.20 CCF35961.1 - 0.0025 17.4 2.9 0.0046 16.6 0.8 2.3 2 0 0 2 2 2 1 Prokaryotic cytochrome b561 eIF-5a PF01287.20 CCF35964.1 - 3.4e-27 94.3 1.5 4.8e-27 93.8 1.5 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.12 CCF35964.1 - 0.0036 17.3 0.1 0.02 14.9 0.0 2.1 2 0 0 2 2 2 1 Elongation factor P (EF-P) KOW-like domain zf-RRN7 PF11781.8 CCF35965.1 - 4.3e-06 26.3 1.5 8.8e-06 25.3 1.5 1.6 1 0 0 1 1 1 1 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 ubiquitin PF00240.23 CCF35966.1 - 2.6e-33 113.6 0.5 3.4e-33 113.2 0.5 1.1 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_L40e PF01020.17 CCF35966.1 - 1.9e-31 107.7 10.1 2.8e-31 107.1 10.1 1.3 1 0 0 1 1 1 1 Ribosomal L40e family Rad60-SLD PF11976.8 CCF35966.1 - 1.2e-14 53.9 0.4 1.7e-14 53.4 0.4 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 CCF35966.1 - 2.8e-05 24.5 0.1 0.00011 22.6 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain Ubiquitin_5 PF18037.1 CCF35966.1 - 0.0036 17.6 0.0 0.0054 17.1 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 CCF35966.1 - 0.0043 16.9 0.0 0.006 16.5 0.0 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 CCF35966.1 - 0.0082 16.2 0.0 0.017 15.2 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 CCF35966.1 - 0.017 15.7 0.1 0.019 15.5 0.1 1.3 1 1 0 1 1 1 0 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 CCF35966.1 - 0.11 12.5 0.6 6.8 6.8 0.0 2.2 2 0 0 2 2 2 0 Ubiquitin-like domain MFS_1 PF07690.16 CCF35968.1 - 5.3e-30 104.5 38.8 7.8e-30 104.0 38.2 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_4 PF06779.14 CCF35968.1 - 0.00075 18.9 16.7 0.0024 17.2 3.4 2.3 2 0 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB FixQ PF05545.11 CCF35968.1 - 0.35 10.9 0.0 0.35 10.9 0.0 3.2 2 0 0 2 2 2 0 Cbb3-type cytochrome oxidase component FixQ DUF4199 PF13858.6 CCF35969.1 - 3.8 7.9 9.2 16 5.8 9.2 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF4199) Shisa PF13908.6 CCF35969.1 - 8.9 6.5 16.3 0.11 12.7 5.4 2.5 1 1 1 2 2 2 0 Wnt and FGF inhibitory regulator AIM5 PF17050.5 CCF35970.1 - 1.6e-21 76.9 4.5 2e-21 76.6 4.5 1.1 1 0 0 1 1 1 1 Altered inheritance of mitochondria 5 PSCyt3 PF07627.11 CCF35970.1 - 0.035 14.4 0.2 0.043 14.1 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1588) Ribosomal_L17 PF01196.19 CCF35971.1 - 3.1e-33 114.5 0.2 5.3e-33 113.8 0.2 1.4 1 0 0 1 1 1 1 Ribosomal protein L17 Mrpl_C PF18502.1 CCF35971.1 - 0.019 15.3 0.6 0.051 13.8 0.1 1.8 2 0 0 2 2 2 0 54S ribosomal protein L8 C-terminal domain UTP25 PF06862.12 CCF35972.1 - 9.9e-201 667.6 0.9 1.3e-200 667.2 0.9 1.1 1 0 0 1 1 1 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 DEAD PF00270.29 CCF35972.1 - 0.00042 20.1 0.0 0.0093 15.7 0.0 2.2 1 1 0 1 1 1 1 DEAD/DEAH box helicase SASRP1 PF15160.6 CCF35972.1 - 0.05 13.3 1.6 0.094 12.4 1.6 1.3 1 0 0 1 1 1 0 Spermatogenesis-associated serine-rich protein 1 SDA1 PF05285.12 CCF35972.1 - 0.49 9.8 26.1 0.83 9.0 26.1 1.3 1 0 0 1 1 1 0 SDA1 JAB PF01398.21 CCF35973.1 - 1.1e-15 57.6 0.0 1.8e-15 56.9 0.0 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease DUF3113 PF11310.8 CCF35973.1 - 0.091 12.7 0.0 0.22 11.5 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3113) zf-C2H2 PF00096.26 CCF35974.1 - 2.3e-08 34.0 13.1 0.00053 20.3 2.2 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CCF35974.1 - 3.2e-05 24.2 11.2 6.4e-05 23.2 2.5 3.2 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 CCF35974.1 - 0.00025 21.6 12.0 0.12 13.2 1.7 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 CCF35974.1 - 0.012 15.6 0.9 0.012 15.6 0.9 2.0 2 0 0 2 2 2 0 C2H2-type zinc finger zf-met PF12874.7 CCF35974.1 - 0.028 14.8 3.7 0.082 13.3 1.6 2.6 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 CCF35974.1 - 0.087 13.1 0.4 0.087 13.1 0.4 2.4 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.10 CCF35974.1 - 0.15 12.2 1.5 0.78 9.9 0.5 2.3 1 1 1 2 2 2 0 Zinc ribbon domain DUF3669 PF12417.8 CCF35975.1 - 5e-12 45.8 0.1 6.3e-12 45.5 0.1 1.1 1 0 0 1 1 1 1 Zinc finger protein SPRY PF00622.28 CCF35976.1 - 8.4e-17 61.4 0.1 3.1e-16 59.6 0.1 2.0 1 1 0 1 1 1 1 SPRY domain Thioesterase PF00975.20 CCF35977.1 - 1.8e-11 44.6 0.0 2.6e-11 44.1 0.0 1.2 1 0 0 1 1 1 1 Thioesterase domain PP-binding PF00550.25 CCF35977.1 - 5.2e-08 33.1 0.3 3.7e-07 30.4 0.2 2.1 2 0 0 2 2 2 1 Phosphopantetheine attachment site Fungal_trans_2 PF11951.8 CCF35978.1 - 2.3e-07 30.0 0.6 2.3e-07 30.0 0.6 2.0 1 1 1 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF35978.1 - 0.0054 16.8 12.0 0.0099 16.0 12.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain KH_1 PF00013.29 CCF35979.1 - 6.9e-30 102.7 1.3 3.5e-07 30.0 0.0 7.5 8 0 0 8 8 8 6 KH domain HAD_2 PF13419.6 CCF35981.1 - 2.9e-13 50.3 0.0 4e-13 49.8 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CCF35981.1 - 1.9e-11 44.7 0.0 8.5e-11 42.5 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CCF35981.1 - 0.0017 18.4 0.0 0.0032 17.5 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 CCF35981.1 - 0.011 16.2 0.0 0.016 15.6 0.0 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Syja_N PF02383.18 CCF35982.1 - 8.4e-74 248.8 0.0 1.8e-73 247.6 0.0 1.6 2 0 0 2 2 2 1 SacI homology domain Exo_endo_phos PF03372.23 CCF35982.1 - 6.2e-10 39.0 0.0 1.2e-09 38.1 0.0 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family COesterase PF00135.28 CCF35985.1 - 8.6e-58 196.4 0.0 2.4e-57 195.0 0.0 1.6 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CCF35985.1 - 3e-05 24.0 0.1 0.00029 20.8 0.1 2.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CCF35985.1 - 0.00068 19.2 0.0 0.0011 18.5 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Esterase PF00756.20 CCF35985.1 - 0.055 13.1 0.1 0.094 12.3 0.1 1.4 1 0 0 1 1 1 0 Putative esterase LPAM_2 PF13627.6 CCF35985.1 - 1.4 8.9 5.3 2.7 8.0 5.3 1.5 1 0 0 1 1 1 0 Prokaryotic lipoprotein-attachment site Abhydrolase_1 PF00561.20 CCF35986.1 - 5.7e-13 49.1 0.0 1.1e-12 48.1 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CCF35986.1 - 1.5e-08 34.2 0.0 2.9e-08 33.3 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CCF35986.1 - 0.00094 19.8 0.0 0.0024 18.5 0.0 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S28 PF05577.12 CCF35986.1 - 0.0011 17.8 0.0 0.0016 17.3 0.0 1.2 1 0 0 1 1 1 1 Serine carboxypeptidase S28 Esterase PF00756.20 CCF35986.1 - 0.013 15.2 0.0 0.02 14.6 0.0 1.3 1 0 0 1 1 1 0 Putative esterase Peptidase_S9 PF00326.21 CCF35986.1 - 0.11 11.9 0.0 0.47 9.9 0.0 1.8 1 1 0 1 1 1 0 Prolyl oligopeptidase family ATG16 PF08614.11 CCF35987.1 - 0.064 13.5 0.8 0.11 12.8 0.8 1.3 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) CENP-O PF09496.10 CCF35988.1 - 1.9e-72 243.7 2.7 5.8e-72 242.1 0.1 2.0 2 0 0 2 2 2 1 Cenp-O kinetochore centromere component DUF2046 PF09755.9 CCF35988.1 - 0.028 13.6 1.5 1.6 7.8 0.3 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein H4 (DUF2046) Tektin PF03148.14 CCF35988.1 - 0.19 10.5 5.6 0.066 12.0 2.9 1.5 2 0 0 2 2 2 0 Tektin family bZIP_2 PF07716.15 CCF35988.1 - 0.27 11.4 1.8 8.5 6.6 0.3 2.5 2 0 0 2 2 2 0 Basic region leucine zipper Cep57_CLD_2 PF14197.6 CCF35988.1 - 0.31 11.1 0.2 0.31 11.1 0.2 2.3 3 0 0 3 3 3 0 Centrosome localisation domain of PPC89 LPP PF04728.13 CCF35988.1 - 8.7 6.8 7.9 0.47 10.9 1.2 2.4 3 0 0 3 3 3 0 Lipoprotein leucine-zipper Acatn PF13000.7 CCF35989.1 - 7.7e-165 549.5 18.6 5.7e-84 282.6 8.0 3.2 1 1 2 3 3 3 3 Acetyl-coenzyme A transporter 1 DFP PF04127.15 CCF35990.1 - 2.1e-05 24.5 0.0 0.0033 17.3 0.0 2.1 2 0 0 2 2 2 2 DNA / pantothenate metabolism flavoprotein bZIP_1 PF00170.21 CCF35991.1 - 5.2e-07 29.7 4.9 1.1e-06 28.6 4.9 1.5 1 0 0 1 1 1 1 bZIP transcription factor MFS_1 PF07690.16 CCF35992.1 - 1.1e-24 87.1 43.9 3.7e-23 82.0 32.4 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DIT1_PvcA PF05141.12 CCF35993.1 - 6.4e-87 291.5 0.0 1e-86 290.8 0.0 1.3 1 0 0 1 1 1 1 Pyoverdine/dityrosine biosynthesis protein Herpes_BLLF1 PF05109.13 CCF35993.1 - 0.17 9.8 0.8 0.24 9.4 0.8 1.2 1 0 0 1 1 1 0 Herpes virus major outer envelope glycoprotein (BLLF1) Hydantoinase_A PF01968.18 CCF35994.1 - 1.2e-25 90.4 11.1 1.3e-20 73.9 1.3 3.2 2 1 1 3 3 3 3 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 CCF35994.1 - 4.2e-25 88.5 0.6 4.1e-23 82.0 0.5 2.8 2 1 0 2 2 2 1 Hydantoinase/oxoprolinase N-terminal region MutL PF13941.6 CCF35994.1 - 0.00051 18.8 1.8 0.59 8.7 0.0 2.4 2 0 0 2 2 2 2 MutL protein BcrAD_BadFG PF01869.20 CCF35994.1 - 0.0043 16.6 0.1 0.0043 16.6 0.1 2.7 3 1 0 3 3 3 1 BadF/BadG/BcrA/BcrD ATPase family StbA PF06406.11 CCF35994.1 - 0.29 10.3 2.7 1.3 8.2 0.0 2.7 3 1 0 3 3 3 0 StbA protein acVLRF1 PF18859.1 CCF35996.1 - 5.5 7.3 8.2 27 5.1 3.0 2.5 2 1 0 2 2 2 0 Actinobacteria/chloroflexi VLRF1 release factor CsbD PF05532.12 CCF35996.1 - 6 6.9 14.3 0.19 11.6 1.4 3.6 4 0 0 4 4 4 0 CsbD-like zf_UBZ PF18439.1 CCF35997.1 - 0.018 14.7 2.3 0.05 13.2 0.1 2.4 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-C2H2_4 PF13894.6 CCF35997.1 - 0.077 13.9 3.4 0.25 12.3 0.1 3.1 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2 PF00096.26 CCF35997.1 - 0.077 13.5 0.1 0.077 13.5 0.1 2.9 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CCF35997.1 - 0.21 12.1 0.4 1.2 9.7 0.0 2.4 2 0 0 2 2 2 0 Zinc-finger double domain HNH_5 PF14279.6 CCF35997.1 - 0.32 10.9 2.2 2.4 8.1 0.1 2.6 3 0 0 3 3 3 0 HNH endonuclease zinc_ribbon_4 PF13717.6 CCF35997.1 - 0.95 9.4 3.3 48 4.0 0.2 3.4 3 0 0 3 3 3 0 zinc-ribbon domain SMC_N PF02463.19 CCF35998.1 - 6.7e-60 202.2 0.4 1.1e-58 198.3 0.4 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 CCF35998.1 - 2.5e-25 89.1 0.0 1.3e-24 86.7 0.0 2.3 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.6 CCF35998.1 - 2.5e-10 41.2 16.8 2.5e-10 41.2 16.8 6.9 2 2 3 5 5 1 1 AAA domain AAA_21 PF13304.6 CCF35998.1 - 9.9e-10 38.7 3.1 1.3e-05 25.1 0.2 4.0 3 2 2 5 5 5 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CCF35998.1 - 5.4e-08 32.5 0.1 1.2e-07 31.4 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 CCF35998.1 - 0.00024 20.9 28.1 0.00024 20.9 28.1 4.4 2 2 1 3 3 2 1 AAA ATPase domain CEP209_CC5 PF16574.5 CCF35998.1 - 0.0067 16.6 9.6 0.0067 16.6 9.6 7.6 7 1 1 8 8 7 1 Coiled-coil region of centrosome protein CE290 UPF0242 PF06785.11 CCF35998.1 - 0.0071 16.5 19.5 0.0071 16.5 19.5 6.8 3 2 3 6 6 3 1 Uncharacterised protein family (UPF0242) N-terminus SbcCD_C PF13558.6 CCF35998.1 - 0.015 15.5 0.0 0.083 13.1 0.0 2.3 2 0 0 2 2 1 0 Putative exonuclease SbcCD, C subunit GAT PF03127.14 CCF35998.1 - 0.049 13.9 11.5 0.11 12.8 1.2 4.0 3 0 0 3 3 2 0 GAT domain DUF3655 PF12379.8 CCF35998.1 - 0.22 11.8 3.9 0.98 9.8 3.9 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3655) RIH_assoc PF08454.11 CCF35998.1 - 0.3 11.0 2.3 1.7 8.5 0.3 2.8 2 0 0 2 2 2 0 RyR and IP3R Homology associated Spc7 PF08317.11 CCF35998.1 - 1.1 8.1 123.0 0.17 10.7 6.0 7.2 3 2 4 7 7 7 0 Spc7 kinetochore protein DUF1730 PF08331.10 CCF35998.1 - 1.2 9.1 9.2 0.49 10.3 0.8 4.3 4 0 0 4 4 4 0 Domain of unknown function (DUF1730) ATG16 PF08614.11 CCF35998.1 - 9 6.5 113.2 0.81 9.9 12.5 7.4 4 2 2 6 6 6 0 Autophagy protein 16 (ATG16) DUF2838 PF10998.8 CCF35999.1 - 2.9e-45 153.1 11.1 2.9e-45 153.1 11.1 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF2838) Tropomyosin_1 PF12718.7 CCF35999.1 - 0.011 15.9 1.0 0.02 15.1 1.0 1.3 1 0 0 1 1 1 0 Tropomyosin like Prominin PF05478.11 CCF35999.1 - 0.2 9.6 0.0 0.27 9.1 0.0 1.1 1 0 0 1 1 1 0 Prominin TBCA PF02970.16 CCF35999.1 - 0.24 11.8 1.8 4.5 7.7 1.6 2.3 2 0 0 2 2 2 0 Tubulin binding cofactor A Val_tRNA-synt_C PF10458.9 CCF35999.1 - 0.47 10.8 4.0 4.4 7.6 3.3 2.4 2 0 0 2 2 2 0 Valyl tRNA synthetase tRNA binding arm TMEM237 PF15383.6 CCF35999.1 - 0.67 9.0 3.8 3.5 6.7 3.8 2.0 1 1 0 1 1 1 0 Transmembrane protein 237 WD40 PF00400.32 CCF36000.1 - 6.6e-20 71.1 15.3 0.00039 21.2 0.1 6.7 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF36000.1 - 3.9e-13 49.5 6.2 4.3e-05 23.7 0.5 4.4 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CCF36000.1 - 6.6e-08 32.7 0.1 0.00084 19.3 0.1 2.9 2 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 CCF36000.1 - 0.047 12.6 0.1 0.35 9.8 0.0 2.3 3 0 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein GMC_oxred_N PF00732.19 CCF36001.1 - 1.1e-33 116.9 0.0 1.6e-33 116.3 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCF36001.1 - 1.3e-33 116.5 0.0 2.8e-33 115.5 0.0 1.6 1 1 0 1 1 1 1 GMC oxidoreductase FMN_dh PF01070.18 CCF36002.1 - 8.2e-105 350.6 0.0 9.6e-105 350.4 0.0 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.25 CCF36002.1 - 0.00032 19.8 0.1 0.00054 19.1 0.1 1.3 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.17 CCF36002.1 - 0.0031 16.7 0.1 0.0043 16.2 0.1 1.1 1 0 0 1 1 1 1 Conserved region in glutamate synthase His_biosynth PF00977.21 CCF36002.1 - 0.0039 16.7 0.3 0.017 14.6 0.2 1.8 1 1 0 1 1 1 1 Histidine biosynthesis protein AMP-binding PF00501.28 CCF36003.1 - 4.4e-149 496.7 0.0 1.3e-76 257.9 0.0 2.2 2 0 0 2 2 2 2 AMP-binding enzyme NAD_binding_4 PF07993.12 CCF36003.1 - 2.4e-39 135.1 0.0 4.2e-39 134.3 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein Condensation PF00668.20 CCF36003.1 - 5.5e-39 134.1 0.0 1.1e-34 120.0 0.0 2.4 2 0 0 2 2 2 2 Condensation domain PP-binding PF00550.25 CCF36003.1 - 3.6e-16 59.3 0.2 1.2e-09 38.4 0.0 3.2 3 0 0 3 3 3 2 Phosphopantetheine attachment site AMP-binding_C PF13193.6 CCF36003.1 - 2.7e-07 31.5 0.0 0.00013 22.9 0.0 2.8 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Epimerase PF01370.21 CCF36003.1 - 5.4e-06 26.1 0.0 1.1e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CCF36003.1 - 0.021 14.2 0.1 0.18 11.1 0.1 2.1 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase DUF1820 PF08850.11 CCF36003.1 - 0.13 12.8 0.0 0.34 11.4 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1820) MFS_1 PF07690.16 CCF36004.1 - 4.3e-39 134.4 38.3 8.8e-39 133.4 38.1 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 CCF36004.1 - 6.4e-13 48.0 5.7 6.4e-13 48.0 5.7 1.6 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 CCF36004.1 - 4.8e-10 38.9 23.2 2.6e-09 36.5 6.2 3.0 2 1 0 3 3 3 2 Sugar (and other) transporter DHHC PF01529.20 CCF36004.1 - 0.6 10.2 4.3 1.2 9.2 0.1 2.8 3 0 0 3 3 3 0 DHHC palmitoyltransferase Meth_synt_2 PF01717.18 CCF36005.1 - 3.7e-11 42.9 0.0 1.1e-08 34.7 0.0 2.8 2 1 0 2 2 2 2 Cobalamin-independent synthase, Catalytic domain DUF934 PF06073.12 CCF36005.1 - 0.087 12.7 0.0 0.21 11.5 0.0 1.6 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF934) Rhodanese PF00581.20 CCF36006.1 - 2.2e-13 50.7 0.0 3.1e-13 50.2 0.0 1.2 1 0 0 1 1 1 1 Rhodanese-like domain Peroxidase_2 PF01328.17 CCF36009.1 - 2.3e-43 148.9 0.0 3e-43 148.5 0.0 1.1 1 0 0 1 1 1 1 Peroxidase, family 2 ADH_N PF08240.12 CCF36010.1 - 1.6e-24 85.9 4.2 2.7e-24 85.2 4.2 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCF36010.1 - 3.4e-20 72.4 0.0 5.3e-20 71.7 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCF36010.1 - 5.2e-11 43.7 0.0 9.3e-11 42.9 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 CCF36010.1 - 0.00081 18.8 0.0 0.0013 18.1 0.0 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 CCF36010.1 - 0.0011 18.4 0.0 0.0017 17.7 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain CBM_10 PF02013.16 CCF36010.1 - 0.1 13.1 1.3 6.9 7.2 0.1 2.7 2 0 0 2 2 2 0 Cellulose or protein binding domain PGAP1 PF07819.13 CCF36011.1 - 1.1e-93 313.3 0.0 1.5e-93 312.8 0.0 1.2 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_1 PF00561.20 CCF36011.1 - 0.0057 16.3 0.0 0.018 14.7 0.0 1.8 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCF36011.1 - 0.011 16.4 1.5 0.019 15.6 0.1 2.2 2 0 0 2 2 2 0 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCF36011.1 - 0.016 14.5 0.0 0.031 13.5 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Palm_thioest PF02089.15 CCF36011.1 - 0.052 13.4 0.0 0.086 12.7 0.0 1.4 1 0 0 1 1 1 0 Palmitoyl protein thioesterase DUF676 PF05057.14 CCF36011.1 - 0.082 12.4 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 Putative serine esterase (DUF676) SARAF PF06682.12 CCF36011.1 - 3.2 7.3 4.2 5.4 6.6 4.2 1.3 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Uds1 PF15456.6 CCF36012.1 - 6.1e-37 126.7 11.6 6.1e-37 126.7 11.6 8.0 3 2 3 7 7 7 1 Up-regulated During Septation Fez1 PF06818.15 CCF36012.1 - 0.0055 17.2 22.0 0.0055 17.2 22.0 6.6 2 1 3 6 6 6 1 Fez1 ATG16 PF08614.11 CCF36012.1 - 0.0069 16.6 27.0 0.0069 16.6 27.0 7.6 4 2 3 7 7 7 3 Autophagy protein 16 (ATG16) UPF0242 PF06785.11 CCF36012.1 - 0.0071 16.5 7.3 0.0071 16.5 7.3 7.3 4 2 2 7 7 7 2 Uncharacterised protein family (UPF0242) N-terminus MOSC PF03473.17 CCF36012.1 - 0.051 13.6 2.1 0.099 12.7 0.2 2.4 2 1 1 3 3 3 0 MOSC domain DUF4407 PF14362.6 CCF36012.1 - 4 6.7 89.9 0.27 10.6 7.2 6.1 2 1 4 6 6 6 0 Domain of unknown function (DUF4407) DUF1751 PF08551.10 CCF36014.1 - 0.009 16.6 0.0 0.013 16.1 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic integral membrane protein (DUF1751) Gly-zipper_Omp PF13488.6 CCF36014.1 - 0.069 13.2 0.1 0.14 12.2 0.1 1.5 1 0 0 1 1 1 0 Glycine zipper Rhomboid PF01694.22 CCF36014.1 - 0.11 12.5 2.1 0.22 11.5 2.1 1.4 1 1 0 1 1 1 0 Rhomboid family DnaJ_C PF01556.18 CCF36015.1 - 1.1e-38 132.7 0.0 1.6e-38 132.1 0.0 1.3 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 CCF36015.1 - 4.6e-23 81.1 0.8 8.6e-23 80.2 0.8 1.5 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 CCF36015.1 - 9.5e-10 38.7 21.6 1.9e-09 37.7 21.6 1.6 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 CCF36015.1 - 0.18 11.8 14.1 0.63 10.1 2.7 2.9 2 0 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 CCF36015.1 - 4.4 7.4 7.3 28 4.8 7.4 2.1 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA SAP30_Sin3_bdg PF13867.6 CCF36016.1 - 2.3e-09 37.4 2.0 3.5e-08 33.7 0.3 2.3 2 0 0 2 2 2 2 Sin3 binding region of histone deacetylase complex subunit SAP30 Glyco_trans_2_3 PF13632.6 CCF36018.1 - 8.1e-13 48.7 0.0 8.1e-13 48.7 0.0 1.6 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 CCF36018.1 - 0.00014 21.7 0.0 0.0015 18.4 0.0 2.2 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 CCF36018.1 - 0.11 12.0 0.0 0.22 11.0 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 21 ORC2 PF04084.14 CCF36019.1 - 6.6e-120 400.0 0.0 7.5e-120 399.8 0.0 1.0 1 0 0 1 1 1 1 Origin recognition complex subunit 2 NTP_transf_3 PF12804.7 CCF36019.1 - 0.029 14.7 0.8 0.05 14.0 0.8 1.4 1 0 0 1 1 1 0 MobA-like NTP transferase domain MatE PF01554.18 CCF36020.1 - 0.038 13.7 2.2 0.68 9.6 0.3 2.9 2 0 0 2 2 2 0 MatE TGT PF01702.18 CCF36021.1 - 3e-46 158.2 0.0 3.5e-46 158.0 0.0 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase NDUFA12 PF05071.16 CCF36022.1 - 5.2e-31 107.3 1.9 7e-31 106.9 1.9 1.2 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 PLDc_2 PF13091.6 CCF36023.1 - 5.2e-16 58.8 0.0 5.4e-08 32.8 0.0 2.5 2 1 0 2 2 2 2 PLD-like domain PLDc PF00614.22 CCF36023.1 - 4e-08 33.1 2.5 0.0065 16.6 0.4 3.2 2 1 0 2 2 2 2 Phospholipase D Active site motif DnaG_DnaB_bind PF08278.11 CCF36023.1 - 0.077 13.6 0.0 0.34 11.5 0.0 2.0 2 0 0 2 2 2 0 DNA primase DnaG DnaB-binding p450 PF00067.22 CCF36025.1 - 3.3e-48 164.6 0.0 3.9e-48 164.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Ribosomal_L27e PF01777.18 CCF36026.1 - 5.5e-36 122.8 3.9 8.2e-36 122.2 3.9 1.3 1 0 0 1 1 1 1 Ribosomal L27e protein family NCE101 PF11654.8 CCF36027.1 - 4.9e-09 35.7 0.0 5.7e-09 35.5 0.0 1.1 1 0 0 1 1 1 1 Non-classical export protein 1 TPR_17 PF13431.6 CCF36028.1 - 0.064 13.7 0.5 2 9.0 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat Glyoxalase PF00903.25 CCF36029.1 - 1.3e-23 83.6 0.3 3.4e-16 59.6 0.0 2.2 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 CCF36029.1 - 2e-12 47.3 0.2 4.7e-05 23.6 0.1 2.5 2 1 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 CCF36029.1 - 2.4e-06 27.8 0.3 0.095 12.8 0.0 2.9 2 1 0 2 2 2 2 Glyoxalase-like domain Glyoxalase_5 PF14696.6 CCF36029.1 - 0.0071 16.5 0.1 0.036 14.2 0.0 2.0 2 0 0 2 2 2 1 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal LysR_substrate PF03466.20 CCF36029.1 - 0.0081 15.5 0.0 0.013 14.9 0.0 1.3 1 0 0 1 1 1 1 LysR substrate binding domain ZinT PF09223.11 CCF36029.1 - 0.15 11.9 0.0 0.28 11.0 0.0 1.4 1 0 0 1 1 1 0 ZinT (YodA) periplasmic lipocalin-like zinc-recruitment Amidase PF01425.21 CCF36031.1 - 1.4e-89 301.2 0.0 2e-89 300.6 0.0 1.2 1 0 0 1 1 1 1 Amidase CT_A_B PF02626.15 CCF36031.1 - 1.2e-87 293.9 0.0 2.1e-87 293.1 0.0 1.4 1 0 0 1 1 1 1 Carboxyltransferase domain, subdomain A and B CPSase_L_D2 PF02786.17 CCF36031.1 - 1.6e-62 210.8 0.1 2.6e-62 210.1 0.1 1.2 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain CT_C_D PF02682.16 CCF36031.1 - 2.9e-39 134.9 0.0 5.5e-39 134.0 0.0 1.4 1 0 0 1 1 1 1 Carboxyltransferase domain, subdomain C and D Biotin_carb_N PF00289.22 CCF36031.1 - 8.3e-39 132.5 0.3 2.5e-38 131.0 0.1 2.0 2 0 0 2 2 2 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 CCF36031.1 - 2.3e-32 111.3 0.0 4.4e-32 110.4 0.0 1.5 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Dala_Dala_lig_C PF07478.13 CCF36031.1 - 4.5e-11 42.7 0.0 8.2e-11 41.8 0.0 1.3 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus Biotin_lipoyl PF00364.22 CCF36031.1 - 2.2e-09 37.0 1.0 5.2e-09 35.8 1.0 1.6 1 0 0 1 1 1 1 Biotin-requiring enzyme ATP-grasp PF02222.22 CCF36031.1 - 0.0017 17.9 0.0 0.0038 16.8 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.6 CCF36031.1 - 0.0018 18.0 0.1 2.4 8.1 0.2 2.6 1 1 1 2 2 2 2 Biotin-lipoyl like GCV_H PF01597.19 CCF36031.1 - 0.1 12.5 0.1 0.23 11.4 0.1 1.5 1 0 0 1 1 1 0 Glycine cleavage H-protein ATP-grasp_5 PF13549.6 CCF36031.1 - 0.13 11.7 0.1 0.46 9.9 0.0 1.9 2 0 0 2 2 2 0 ATP-grasp domain RimK PF08443.11 CCF36031.1 - 0.17 11.5 0.0 0.48 10.0 0.0 1.7 1 1 0 1 1 1 0 RimK-like ATP-grasp domain C2 PF00168.30 CCF36034.1 - 2.9e-21 75.7 0.0 2.1e-10 40.8 0.0 3.5 2 1 1 3 3 3 3 C2 domain WBS_methylT PF12589.8 CCF36034.1 - 6.3 7.6 8.9 1.8 9.3 4.7 2.3 2 0 0 2 2 2 0 Methyltransferase involved in Williams-Beuren syndrome MFS_1 PF07690.16 CCF36035.1 - 3.1e-23 82.3 28.8 3.1e-23 82.3 28.8 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Vma12 PF11712.8 CCF36035.1 - 0.027 14.5 1.9 1.2 9.2 0.1 2.7 2 0 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase CSTF1_dimer PF16699.5 CCF36036.1 - 0.15 11.8 0.1 0.3 10.9 0.1 1.5 1 0 0 1 1 1 0 Cleavage stimulation factor subunit 1, dimerisation domain IBR PF01485.21 CCF36037.1 - 5e-13 49.1 57.9 2.9e-08 33.8 8.2 4.7 4 1 0 4 4 4 3 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.25 CCF36037.1 - 0.0056 16.5 7.0 0.0056 16.5 7.0 5.0 4 2 1 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CCF36037.1 - 0.019 15.3 8.9 0.019 15.3 8.9 4.9 3 2 1 4 4 4 0 Ring finger domain Sterol_MT_C PF08498.10 CCF36038.1 - 5.1e-26 90.8 1.1 1.4e-25 89.3 1.1 1.8 1 0 0 1 1 1 1 Sterol methyltransferase C-terminal Methyltransf_11 PF08241.12 CCF36038.1 - 1e-23 83.8 0.0 2.3e-23 82.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF36038.1 - 2.4e-22 79.4 0.0 6e-22 78.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF36038.1 - 1.3e-19 70.5 0.0 2.1e-19 69.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF36038.1 - 4.9e-16 59.0 0.1 1.1e-15 57.9 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCF36038.1 - 2.6e-14 53.1 0.0 4.4e-14 52.4 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family CMAS PF02353.20 CCF36038.1 - 1.3e-13 50.9 0.2 1.9e-13 50.3 0.2 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.12 CCF36038.1 - 1.5e-11 44.9 0.2 4.2e-11 43.5 0.0 1.8 2 0 0 2 2 1 1 Methyltransferase domain PrmA PF06325.13 CCF36038.1 - 7.3e-06 25.6 0.3 2.7e-05 23.7 0.0 1.8 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 CCF36038.1 - 5.6e-05 22.7 0.0 0.0001 21.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.19 CCF36038.1 - 0.00014 21.7 0.1 0.00054 19.8 0.1 1.8 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_32 PF13679.6 CCF36038.1 - 0.0012 18.9 0.6 0.0022 18.0 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_8 PF05148.15 CCF36038.1 - 0.0012 18.7 0.0 0.0053 16.6 0.0 1.9 1 1 0 1 1 1 1 Hypothetical methyltransferase RrnaAD PF00398.20 CCF36038.1 - 0.0019 17.4 0.0 0.003 16.7 0.0 1.3 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_2 PF00891.18 CCF36038.1 - 0.0024 17.2 0.1 0.004 16.5 0.1 1.4 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_15 PF09445.10 CCF36038.1 - 0.012 15.2 0.0 0.018 14.6 0.0 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Pox_MCEL PF03291.16 CCF36038.1 - 0.017 14.2 0.7 0.098 11.7 0.1 2.0 2 0 0 2 2 2 0 mRNA capping enzyme TehB PF03848.14 CCF36038.1 - 0.019 14.4 0.0 0.03 13.7 0.0 1.3 1 0 0 1 1 1 0 Tellurite resistance protein TehB MetW PF07021.12 CCF36038.1 - 0.021 14.4 0.0 0.037 13.6 0.0 1.4 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW UPF0020 PF01170.18 CCF36038.1 - 0.038 13.7 0.0 0.08 12.6 0.0 1.6 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 ADH_zinc_N PF00107.26 CCF36038.1 - 0.1 12.6 0.1 0.29 11.1 0.0 1.9 2 1 0 2 2 1 0 Zinc-binding dehydrogenase DUF1642 PF07852.11 CCF36038.1 - 0.12 13.0 0.9 0.29 11.7 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1642) FtsJ PF01728.19 CCF36038.1 - 0.12 12.5 0.1 0.34 11.0 0.1 1.6 1 1 1 2 2 2 0 FtsJ-like methyltransferase LrgB PF04172.16 CCF36039.1 - 2.5e-23 82.7 8.5 1.2e-22 80.5 8.5 2.0 1 1 0 1 1 1 1 LrgB-like family HAUS-augmin3 PF14932.6 CCF36040.1 - 0.0053 16.4 16.6 0.13 11.8 16.2 2.5 1 1 0 1 1 1 1 HAUS augmin-like complex subunit 3 DUF501 PF04417.12 CCF36040.1 - 0.056 13.3 1.6 0.11 12.3 1.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF501) HSDR_N_2 PF13588.6 CCF36040.1 - 0.056 13.4 0.2 0.18 11.8 0.0 2.0 1 1 1 2 2 2 0 Type I restriction enzyme R protein N terminus (HSDR_N) Nup54_C PF18437.1 CCF36040.1 - 0.056 13.3 0.1 0.16 11.9 0.1 1.8 1 0 0 1 1 1 0 Nup54 C-terminal interacting domain STAT_alpha PF01017.20 CCF36040.1 - 0.19 11.6 13.7 0.031 14.2 8.8 2.0 3 0 0 3 3 3 0 STAT protein, all-alpha domain DLP_helical PF18709.1 CCF36040.1 - 0.38 9.9 9.3 0.78 8.9 9.3 1.6 1 1 0 1 1 1 0 Dynamin-like helical domain Allexi_40kDa PF05549.11 CCF36040.1 - 0.46 10.0 11.6 0.51 9.8 6.2 2.1 1 1 1 2 2 2 0 Allexivirus 40kDa protein PIN_2 PF10130.9 CCF36040.1 - 0.82 9.9 4.8 1.3 9.2 0.9 2.6 2 1 1 3 3 3 0 PIN domain FUSC PF04632.12 CCF36040.1 - 0.85 8.1 6.1 1.2 7.6 6.1 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family ArAE_2_N PF10337.9 CCF36040.1 - 2.4 7.1 7.5 0.78 8.7 4.5 1.6 2 0 0 2 2 2 0 Putative ER transporter, 6TM, N-terminal Phage_Gp23 PF10669.9 CCF36040.1 - 3.9 7.8 11.6 9.4 6.6 1.8 2.4 1 1 1 2 2 2 0 Protein gp23 (Bacteriophage A118) DUF4061 PF13270.6 CCF36040.1 - 3.9 7.8 10.3 2 8.8 5.1 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4061) DUF4795 PF16043.5 CCF36040.1 - 4 7.0 18.4 6.2 6.4 17.7 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) YabA PF06156.13 CCF36040.1 - 7.7 7.2 14.6 12 6.6 5.7 3.1 1 1 1 2 2 2 0 Initiation control protein YabA PIEZO PF15917.5 CCF36040.1 - 8.4 5.8 10.1 9.1 5.7 7.6 1.9 1 1 0 2 2 2 0 Piezo SNARE PF05739.19 CCF36041.1 - 0.00057 19.8 0.0 0.0024 17.8 0.0 2.0 2 0 0 2 2 2 1 SNARE domain DUF4446 PF14584.6 CCF36041.1 - 0.081 12.9 0.1 0.21 11.5 0.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) TraU PF06834.11 CCF36041.1 - 0.17 11.1 0.0 0.23 10.7 0.0 1.2 1 0 0 1 1 1 0 TraU protein Aminotran_1_2 PF00155.21 CCF36042.1 - 3.4e-88 296.3 0.0 3.9e-88 296.0 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Pes-10 PF07149.11 CCF36043.1 - 4.2 6.3 8.2 5.8 5.9 8.2 1.1 1 0 0 1 1 1 0 Pes-10 PAXIP1_C PF15364.6 CCF36043.1 - 5 7.4 8.2 18 5.7 8.3 1.9 1 1 0 1 1 1 0 PAXIP1-associated-protein-1 C term PTIP binding protein PGP_phosphatase PF09419.10 CCF36044.1 - 1.6e-65 219.8 0.0 1.9e-65 219.6 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial PGP phosphatase Hydrolase_like PF13242.6 CCF36044.1 - 0.00015 21.8 0.0 0.00025 21.0 0.0 1.5 1 1 0 1 1 1 1 HAD-hyrolase-like MTHFR PF02219.17 CCF36044.1 - 0.004 16.5 0.0 0.0053 16.1 0.0 1.1 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase Hydrolase PF00702.26 CCF36044.1 - 0.016 15.5 0.0 0.022 15.1 0.0 1.2 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase PBP1_TM PF14812.6 CCF36045.1 - 2.5 8.5 18.2 4.5 7.7 6.7 2.6 2 1 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Cid2 PF09774.9 CCF36047.1 - 1.2e-54 185.1 0.0 1.5e-54 184.8 0.0 1.1 1 0 0 1 1 1 1 Caffeine-induced death protein 2 NARP1 PF12569.8 CCF36048.1 - 7.2e-192 638.9 21.0 6.4e-190 632.4 15.9 2.2 2 0 0 2 2 2 2 NMDA receptor-regulated protein 1 TPR_19 PF14559.6 CCF36048.1 - 5.8e-20 71.6 24.7 3.4e-05 24.3 2.4 7.1 7 0 0 7 7 6 4 Tetratricopeptide repeat TPR_2 PF07719.17 CCF36048.1 - 3.3e-14 51.8 34.5 0.00017 21.4 0.3 10.8 11 0 0 11 11 11 6 Tetratricopeptide repeat TPR_16 PF13432.6 CCF36048.1 - 2.1e-13 50.7 36.7 0.016 15.9 0.1 10.3 11 2 3 14 14 10 6 Tetratricopeptide repeat ANAPC3 PF12895.7 CCF36048.1 - 4.2e-12 46.1 16.2 6.1e-05 23.2 1.5 5.0 4 1 0 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 CCF36048.1 - 4.9e-11 42.5 22.8 0.0072 17.1 0.0 10.6 7 3 4 11 11 10 2 Tetratricopeptide repeat TPR_1 PF00515.28 CCF36048.1 - 1.8e-10 40.2 16.2 1.9e-05 24.2 0.5 7.7 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_11 PF13414.6 CCF36048.1 - 3.2e-09 36.3 7.6 6.5e-05 22.5 0.1 6.1 7 0 0 7 7 7 1 TPR repeat TPR_9 PF13371.6 CCF36048.1 - 5.9e-09 35.9 9.8 0.0013 18.8 0.3 6.7 5 2 1 6 6 6 2 Tetratricopeptide repeat TPR_12 PF13424.6 CCF36048.1 - 2.2e-08 34.3 24.7 1.1 9.6 0.1 8.6 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_17 PF13431.6 CCF36048.1 - 3.9e-07 30.0 9.5 0.45 11.0 0.0 7.1 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_MalT PF17874.1 CCF36048.1 - 9.3e-06 25.2 11.7 0.037 13.4 0.1 3.4 2 1 1 3 3 3 2 MalT-like TPR region TPR_8 PF13181.6 CCF36048.1 - 7.2e-05 22.7 16.4 0.00078 19.5 0.2 6.9 7 0 0 7 7 7 1 Tetratricopeptide repeat Sel1 PF08238.12 CCF36048.1 - 0.12 13.2 3.1 11 6.9 0.0 3.5 2 0 0 2 2 2 0 Sel1 repeat TPR_4 PF07721.14 CCF36048.1 - 0.18 12.5 17.6 4.7 8.1 0.7 7.0 8 0 0 8 8 7 0 Tetratricopeptide repeat TPR_3 PF07720.12 CCF36048.1 - 0.19 11.7 3.5 0.8 9.8 0.2 3.6 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 CCF36048.1 - 0.66 10.1 12.1 7.5 6.8 0.1 6.1 7 0 0 7 7 5 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 CCF36048.1 - 0.67 10.1 16.1 6.6 6.9 0.0 5.6 6 0 0 6 6 6 0 Fis1 C-terminal tetratricopeptide repeat TPR_10 PF13374.6 CCF36048.1 - 5.3 7.1 16.8 37 4.4 0.0 7.1 8 0 0 8 8 8 0 Tetratricopeptide repeat Ribosomal_L19e PF01280.20 CCF36049.1 - 1.4e-61 206.8 6.4 1.4e-61 206.8 6.4 1.6 1 1 1 2 2 2 1 Ribosomal protein L19e HEAT PF02985.22 CCF36050.1 - 5.8e-14 51.0 13.5 0.017 15.3 0.1 9.5 10 0 0 10 10 9 3 HEAT repeat HEAT_2 PF13646.6 CCF36050.1 - 5.4e-12 45.9 15.5 4.9e-05 23.6 3.1 6.5 4 3 4 8 8 8 5 HEAT repeats HEAT_EZ PF13513.6 CCF36050.1 - 1.4e-10 41.4 22.8 0.049 14.2 0.2 8.6 9 2 2 11 11 9 5 HEAT-like repeat MMS19_C PF12460.8 CCF36050.1 - 3.6e-09 36.3 11.1 0.00033 19.9 0.2 4.6 3 1 1 4 4 4 2 RNAPII transcription regulator C-terminal ParcG PF10274.9 CCF36050.1 - 3.7e-09 36.9 0.7 9.8e-05 22.6 0.0 3.5 2 2 2 4 4 4 2 Parkin co-regulated protein CLASP_N PF12348.8 CCF36050.1 - 8.5e-07 28.8 0.1 0.0036 16.9 0.0 3.2 2 1 1 3 3 3 2 CLASP N terminal Cnd1 PF12717.7 CCF36050.1 - 1.4e-06 28.4 10.7 0.56 10.2 2.6 6.4 2 2 3 6 6 6 1 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 CCF36050.1 - 6.6e-06 26.6 0.8 1.1 9.9 0.0 4.8 4 2 0 4 4 4 1 Vacuolar 14 Fab1-binding region DUF3385 PF11865.8 CCF36050.1 - 0.00013 21.9 0.2 0.46 10.4 0.0 4.0 4 1 1 5 5 5 1 Domain of unknown function (DUF3385) UME PF08064.13 CCF36050.1 - 0.00016 21.5 2.2 1.7 8.6 0.0 5.1 5 2 1 6 6 5 2 UME (NUC010) domain TFCD_C PF12612.8 CCF36050.1 - 0.00017 21.5 1.1 0.0075 16.1 0.0 3.6 2 1 2 4 4 4 1 Tubulin folding cofactor D C terminal DRIM PF07539.12 CCF36050.1 - 0.00027 19.4 8.2 0.086 11.1 0.2 3.7 3 1 1 4 4 4 3 Down-regulated in metastasis Pes-10 PF07149.11 CCF36050.1 - 0.00094 18.3 0.0 0.0019 17.3 0.0 1.4 1 0 0 1 1 1 1 Pes-10 Dopey_N PF04118.14 CCF36050.1 - 0.025 13.7 0.7 2.5 7.1 0.0 3.6 3 1 1 4 4 4 0 Dopey, N-terminal FANCI_S2 PF14676.6 CCF36050.1 - 0.037 14.3 0.9 0.82 10.0 0.0 3.2 3 1 0 3 3 2 0 FANCI solenoid 2 Ipi1_N PF12333.8 CCF36050.1 - 0.038 14.6 0.2 0.97 10.1 0.1 3.1 2 1 1 3 3 3 0 Rix1 complex component involved in 60S ribosome maturation Staph_haemo PF05480.11 CCF36050.1 - 0.042 13.6 0.0 0.15 11.9 0.0 1.9 1 0 0 1 1 1 0 Staphylococcus haemolytic protein DUF937 PF06078.11 CCF36050.1 - 0.058 14.0 1.4 15 6.2 0.0 3.9 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF937) HEAT_PBS PF03130.16 CCF36050.1 - 0.064 13.9 0.9 39 5.3 0.1 3.8 2 0 0 2 2 2 0 PBS lyase HEAT-like repeat DUF1981 PF09324.10 CCF36050.1 - 0.072 13.0 0.0 18 5.3 0.0 3.9 5 0 0 5 5 4 0 Domain of unknown function (DUF1981) U3snoRNP10 PF12397.8 CCF36050.1 - 0.19 12.1 7.7 26 5.2 0.0 4.7 4 1 0 4 4 3 0 U3 small nucleolar RNA-associated protein 10 RIX1 PF08167.12 CCF36050.1 - 0.22 11.3 7.4 0.15 11.8 0.2 3.6 3 1 0 3 3 3 0 rRNA processing/ribosome biogenesis DUF4844 PF16133.5 CCF36050.1 - 1.1 9.9 6.3 4 8.0 0.0 4.0 5 0 0 5 5 4 0 Domain of unknown function (DUF4844) Zn_clus PF00172.18 CCF36052.1 - 2.6e-08 33.8 9.0 3.9e-08 33.3 9.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 CCF36052.1 - 0.00023 20.1 0.5 0.00039 19.4 0.5 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain RTA1 PF04479.13 CCF36053.1 - 7.1e-71 238.1 7.8 7.1e-71 238.1 7.8 1.5 2 0 0 2 2 2 1 RTA1 like protein Glyco_hydro_3 PF00933.21 CCF36054.1 - 3.9e-08 33.0 0.0 5e-08 32.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain p450 PF00067.22 CCF36055.1 - 1.5e-50 172.3 0.0 2.6e-50 171.6 0.0 1.3 1 0 0 1 1 1 1 Cytochrome P450 DASH_Ask1 PF08655.10 CCF36057.1 - 3.4e-31 106.9 0.3 5.3e-31 106.3 0.3 1.3 1 0 0 1 1 1 1 DASH complex subunit Ask1 Lin-8 PF03353.15 CCF36057.1 - 0.24 10.9 5.6 0.16 11.5 4.0 1.5 1 1 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF3073 PF11273.8 CCF36057.1 - 0.41 11.4 0.2 0.41 11.4 0.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3073) GCP_C_terminal PF04130.13 CCF36058.1 - 3.5e-80 269.8 0.0 3.9e-79 266.3 0.0 2.1 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 CCF36058.1 - 3.4e-30 105.7 0.1 5.8e-30 105.0 0.1 1.4 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal Eaf7 PF07904.13 CCF36059.1 - 1.7e-26 92.6 0.3 1.7e-26 92.6 0.3 3.3 2 1 0 2 2 2 1 Chromatin modification-related protein EAF7 Nop14 PF04147.12 CCF36059.1 - 3.6 5.7 48.1 5.9 5.0 48.1 1.3 1 0 0 1 1 1 0 Nop14-like family Bromodomain PF00439.25 CCF36060.1 - 5.4e-19 68.0 0.2 5.4e-19 68.0 0.2 1.8 2 0 0 2 2 2 1 Bromodomain Bromo_TP PF07524.13 CCF36060.1 - 1.5e-08 34.5 0.0 3.1e-08 33.5 0.0 1.5 1 0 0 1 1 1 1 Bromodomain associated DUF4611 PF15387.6 CCF36060.1 - 0.00089 19.4 0.5 2.5 8.4 0.1 3.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4611) PSII_Pbs27 PF13326.6 CCF36060.1 - 0.092 13.1 0.1 0.23 11.8 0.1 1.6 1 0 0 1 1 1 0 Photosystem II Pbs27 ING PF12998.7 CCF36060.1 - 0.25 11.9 5.1 0.94 10.1 0.5 2.9 2 0 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding HEPN_Swt1 PF18731.1 CCF36060.1 - 0.26 11.6 1.4 0.73 10.2 0.2 2.4 2 0 0 2 2 2 0 Swt1-like HEPN ArfGap PF01412.18 CCF36062.1 - 1.6e-31 108.8 0.2 3.1e-31 107.9 0.2 1.5 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf ETF PF01012.21 CCF36063.1 - 2.1e-44 151.6 0.5 2.5e-44 151.4 0.5 1.1 1 0 0 1 1 1 1 Electron transfer flavoprotein domain PEP_mutase PF13714.6 CCF36064.1 - 7e-48 163.2 1.4 8e-48 163.0 1.4 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase ICL PF00463.21 CCF36064.1 - 1.2e-20 73.5 0.8 1.5e-20 73.2 0.8 1.1 1 0 0 1 1 1 1 Isocitrate lyase family MR_MLE_C PF13378.6 CCF36064.1 - 0.0036 16.9 0.7 0.011 15.3 0.5 1.7 1 1 1 2 2 2 1 Enolase C-terminal domain-like Usp PF00582.26 CCF36065.1 - 7.4e-16 58.9 0.5 1.6e-15 57.8 0.0 1.9 2 0 0 2 2 2 1 Universal stress protein family DUF3246 PF11596.8 CCF36065.1 - 4.2 6.7 20.4 0.49 9.8 6.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3246) ABA_GPCR PF12430.8 CCF36066.1 - 2.4e-60 203.4 0.4 2.4e-60 203.4 0.4 1.8 2 0 0 2 2 2 1 Abscisic acid G-protein coupled receptor GPHR_N PF12537.8 CCF36066.1 - 1e-26 92.8 0.2 1.4e-25 89.1 0.0 2.4 2 0 0 2 2 2 1 The Golgi pH Regulator (GPHR) Family N-terminal Transp_cyt_pur PF02133.15 CCF36068.1 - 1.1e-71 242.0 32.3 1.2e-71 241.8 32.3 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Phage_holin_Dp1 PF16938.5 CCF36068.1 - 3.4 8.0 12.8 7.9 6.8 1.2 3.6 4 0 0 4 4 4 0 Putative phage holin Dp-1 Glyco_hydro_2_C PF02836.17 CCF36069.1 - 5.1e-98 327.9 0.1 6.9e-98 327.5 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Bgal_small_N PF02929.17 CCF36069.1 - 6.5e-66 222.4 0.0 1.2e-65 221.6 0.0 1.4 1 0 0 1 1 1 1 Beta galactosidase small chain Glyco_hydro_2_N PF02837.18 CCF36069.1 - 4.3e-49 166.7 2.7 8.7e-49 165.7 2.7 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain DUF4981 PF16353.5 CCF36069.1 - 2.5e-20 72.8 0.0 6.1e-20 71.5 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function(DUF4981) Glyco_hydro_2 PF00703.21 CCF36069.1 - 7.8e-09 36.2 0.0 1.9e-08 34.9 0.0 1.7 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 Glyco_hydro_72 PF03198.14 CCF36069.1 - 0.0016 17.8 0.8 0.0045 16.3 0.0 1.9 2 0 0 2 2 2 1 Glucanosyltransferase Glyco_hydro_42 PF02449.15 CCF36069.1 - 0.015 14.7 0.4 0.041 13.2 0.4 1.7 1 0 0 1 1 1 0 Beta-galactosidase TFIID_20kDa PF03847.13 CCF36070.1 - 3.7e-18 65.8 0.1 8.3e-18 64.7 0.1 1.6 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A CBFD_NFYB_HMF PF00808.23 CCF36070.1 - 0.011 16.0 0.4 0.1 12.9 0.0 2.6 3 0 0 3 3 3 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Arb1 PF09692.10 CCF36071.1 - 2.9e-129 431.8 0.0 3.4e-129 431.6 0.0 1.0 1 0 0 1 1 1 1 Argonaute siRNA chaperone (ARC) complex subunit Arb1 Pmp3 PF01679.17 CCF36072.1 - 4.6e-20 71.5 8.3 5.9e-20 71.2 8.3 1.1 1 0 0 1 1 1 1 Proteolipid membrane potential modulator adh_short_C2 PF13561.6 CCF36073.1 - 6.4e-10 39.0 0.0 6.8e-10 38.9 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Sugar_tr PF00083.24 CCF36074.1 - 1.2e-110 370.5 22.8 1.5e-110 370.2 22.8 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF36074.1 - 1.5e-20 73.4 24.9 1.5e-20 73.4 24.9 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily Glyco_hydro_71 PF03659.14 CCF36076.1 - 1.3e-54 185.5 0.1 1.5e-54 185.3 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 71 FAD_binding_4 PF01565.23 CCF36077.1 - 3.4e-20 72.2 1.7 4e-20 72.0 0.4 1.8 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.12 CCF36077.1 - 4.8e-08 33.0 1.0 1.1e-07 31.8 1.0 1.6 1 0 0 1 1 1 1 Berberine and berberine like SPX PF03105.19 CCF36078.1 - 8.7e-42 144.4 0.0 1e-28 101.4 0.0 2.1 1 1 1 2 2 2 2 SPX domain Na_sulph_symp PF00939.19 CCF36078.1 - 2e-36 126.1 41.2 3e-36 125.5 41.2 1.2 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 CCF36078.1 - 5.6e-26 91.4 41.1 5.6e-26 91.4 41.1 2.2 2 1 1 3 3 3 2 Citrate transporter Sporozoite_P67 PF05642.11 CCF36078.1 - 0.45 8.5 7.7 1.6 6.7 7.4 1.8 1 1 0 1 1 1 0 Sporozoite P67 surface antigen Vps39_1 PF10366.9 CCF36079.1 - 9.4e-34 116.0 0.0 2.3e-32 111.5 0.0 3.2 4 0 0 4 4 4 1 Vacuolar sorting protein 39 domain 1 Vps39_2 PF10367.9 CCF36079.1 - 2.8e-30 105.0 0.0 8.6e-30 103.4 0.0 1.9 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 CNH PF00780.22 CCF36079.1 - 8.5e-18 64.9 0.0 2.1e-17 63.7 0.0 1.5 1 1 0 1 1 1 1 CNH domain Clathrin PF00637.20 CCF36079.1 - 2.3e-06 27.6 0.8 0.0003 20.7 0.9 2.8 3 0 0 3 3 3 1 Region in Clathrin and VPS TPR_1 PF00515.28 CCF36079.1 - 0.089 12.7 2.6 0.62 10.0 0.4 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat Cnd1_N PF12922.7 CCF36079.1 - 0.12 12.2 0.0 0.28 11.0 0.0 1.6 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1, N-term TPR_8 PF13181.6 CCF36079.1 - 0.19 12.0 0.5 8.5 6.9 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat FCP1_C PF09309.10 CCF36079.1 - 0.85 9.4 9.4 5.9 6.7 2.1 3.0 3 0 0 3 3 3 0 FCP1, C-terminal Gon7 PF08738.10 CCF36080.1 - 1.6e-10 41.0 4.0 1.2e-09 38.2 0.7 2.1 1 1 1 2 2 2 2 Gon7 family TMEM174 PF15029.6 CCF36080.1 - 0.25 11.0 1.3 0.28 10.9 1.3 1.0 1 0 0 1 1 1 0 Transmembrane protein 174 HbrB PF08539.11 CCF36081.1 - 8.5e-55 185.3 0.0 8.5e-55 185.3 0.0 2.3 3 0 0 3 3 3 1 HbrB-like MFS_1 PF07690.16 CCF36082.1 - 2.4e-30 105.7 30.0 2.4e-30 105.7 30.0 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF36082.1 - 2.4e-06 26.7 23.9 8.5e-06 24.9 23.9 1.9 1 1 0 1 1 1 1 Sugar (and other) transporter TRI12 PF06609.13 CCF36082.1 - 0.0032 16.0 0.6 0.0032 16.0 0.6 2.1 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Mito_carr PF00153.27 CCF36084.1 - 6.1e-41 138.3 6.8 5.2e-15 55.1 0.2 4.1 3 1 0 3 3 3 3 Mitochondrial carrier protein DUF2293 PF10056.9 CCF36085.1 - 2.5e-34 117.4 0.5 7.5e-34 115.8 0.5 1.9 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2293) DRMBL PF07522.14 CCF36086.1 - 8.9e-06 25.9 0.0 2.4e-05 24.5 0.0 1.7 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase RMMBL PF07521.12 CCF36086.1 - 0.032 14.2 0.0 0.071 13.1 0.0 1.5 1 0 0 1 1 1 0 Zn-dependent metallo-hydrolase RNA specificity domain MFS_1 PF07690.16 CCF36087.1 - 1e-12 47.7 36.0 1e-12 47.7 36.0 2.4 1 1 1 2 2 2 1 Major Facilitator Superfamily Polysacc_deac_1 PF01522.21 CCF36088.1 - 7.3e-20 71.1 0.0 9.3e-20 70.8 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide deacetylase AI-2E_transport PF01594.16 CCF36088.1 - 0.0026 17.0 0.0 0.0034 16.6 0.0 1.1 1 0 0 1 1 1 1 AI-2E family transporter DUF2026 PF09641.10 CCF36089.1 - 0.019 14.6 0.1 0.035 13.8 0.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2026) Skp1 PF01466.19 CCF36089.1 - 0.13 12.4 0.3 0.27 11.4 0.3 1.5 1 0 0 1 1 1 0 Skp1 family, dimerisation domain Helicase_C PF00271.31 CCF36092.1 - 1.5e-17 63.9 0.0 3.6e-15 56.3 0.0 2.4 2 0 0 2 2 2 2 Helicase conserved C-terminal domain DEAD PF00270.29 CCF36092.1 - 3.6e-17 62.7 0.0 5.8e-17 62.0 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase RecQ_Zn_bind PF16124.5 CCF36092.1 - 6.5e-14 52.4 2.1 1.6e-13 51.2 2.1 1.7 1 0 0 1 1 1 1 RecQ zinc-binding RNase_H2_suC PF08615.11 CCF36093.1 - 1.2e-24 87.1 0.0 1.5e-24 86.8 0.0 1.2 1 0 0 1 1 1 1 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) MCM PF00493.23 CCF36094.1 - 3.5e-103 343.5 0.3 5.9e-103 342.8 0.3 1.4 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 CCF36094.1 - 9.1e-39 132.2 0.5 1.7e-38 131.3 0.5 1.4 1 0 0 1 1 1 1 MCM OB domain MCM6_C PF18263.1 CCF36094.1 - 1.6e-32 111.9 0.1 3.3e-32 110.9 0.1 1.6 1 0 0 1 1 1 1 MCM6 C-terminal winged-helix domain MCM_lid PF17855.1 CCF36094.1 - 3.7e-24 85.0 0.1 1.1e-23 83.4 0.1 1.9 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 CCF36094.1 - 3.7e-23 82.1 0.1 1.5e-22 80.2 0.1 2.2 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.21 CCF36094.1 - 2.1e-07 30.5 0.0 7.7e-07 28.7 0.0 2.0 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 CCF36094.1 - 0.001 18.8 0.0 0.0022 17.7 0.0 1.5 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_3 PF07726.11 CCF36094.1 - 0.0017 18.2 0.1 0.005 16.7 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DUF3751 PF12571.8 CCF36094.1 - 0.012 15.6 0.2 5.9 7.0 0.0 2.4 2 0 0 2 2 2 0 Phage tail-collar fibre protein AAA_5 PF07728.14 CCF36094.1 - 0.052 13.6 0.0 0.15 12.1 0.0 1.9 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Ribosomal_L26 PF16906.5 CCF36095.1 - 1.7e-36 124.5 1.5 2.3e-36 124.1 1.5 1.2 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal KOW PF00467.29 CCF36095.1 - 1.1e-07 31.5 2.7 1.1e-07 31.5 2.7 1.9 2 0 0 2 2 2 1 KOW motif GMC_oxred_N PF00732.19 CCF36097.1 - 5e-45 154.1 0.0 6.2e-45 153.8 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase DAO PF01266.24 CCF36097.1 - 4.9e-07 29.7 0.0 5.6e-07 29.5 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CCF36097.1 - 8.2e-06 26.0 0.0 1.9e-05 24.8 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 CCF36097.1 - 0.0026 17.0 0.0 0.0051 16.1 0.0 1.4 1 0 0 1 1 1 1 Thi4 family FAD_binding_2 PF00890.24 CCF36097.1 - 0.0042 16.2 0.0 0.0061 15.7 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CCF36097.1 - 0.0054 16.0 0.0 0.0059 15.9 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CCF36097.1 - 0.022 13.5 0.0 0.028 13.1 0.0 1.1 1 0 0 1 1 1 0 HI0933-like protein Lycopene_cycl PF05834.12 CCF36097.1 - 0.036 13.1 0.1 0.048 12.7 0.1 1.1 1 0 0 1 1 1 0 Lycopene cyclase protein NAD_binding_9 PF13454.6 CCF36097.1 - 0.086 12.8 0.1 0.13 12.2 0.1 1.3 1 0 0 1 1 1 0 FAD-NAD(P)-binding TrkA_N PF02254.18 CCF36097.1 - 0.089 13.1 0.2 0.18 12.1 0.2 1.5 1 0 0 1 1 1 0 TrkA-N domain Pyr_redox PF00070.27 CCF36097.1 - 0.11 13.1 0.1 0.21 12.2 0.1 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 CCF36097.1 - 0.16 10.8 0.0 0.24 10.2 0.0 1.2 1 0 0 1 1 1 0 Tryptophan halogenase Radical_SAM PF04055.21 CCF36098.1 - 7.1e-08 33.0 0.0 1.1e-07 32.4 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.6 CCF36098.1 - 2.9e-05 24.3 0.0 5.5e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 CCF36098.1 - 0.016 15.3 0.0 0.036 14.2 0.0 1.6 1 0 0 1 1 1 0 4Fe-4S single cluster domain DUF4637 PF15470.6 CCF36098.1 - 0.075 12.8 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) DUF737 PF05300.11 CCF36099.1 - 0.012 16.0 0.2 0.018 15.4 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF737) DUF3328 PF11807.8 CCF36100.1 - 3.9e-42 144.5 0.1 5.1e-42 144.1 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Nop10p PF04135.12 CCF36101.1 - 2.6e-22 78.6 0.1 3.1e-22 78.4 0.1 1.1 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family NOB1_Zn_bind PF08772.11 CCF36102.1 - 7.2e-32 109.4 4.0 1.2e-31 108.6 4.0 1.4 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like PIN_6 PF17146.4 CCF36102.1 - 2.2e-29 101.8 0.3 5.3e-29 100.6 0.0 1.8 2 0 0 2 2 2 1 PIN domain of ribonuclease PIN_5 PF08745.11 CCF36102.1 - 0.058 12.8 0.4 11 5.4 0.0 2.9 2 1 1 3 3 3 0 PINc domain ribonuclease Ribosomal_S17e PF00833.18 CCF36102.1 - 0.069 13.1 1.2 0.18 11.8 0.5 1.9 2 0 0 2 2 2 0 Ribosomal S17 Baculo_helicase PF04735.12 CCF36102.1 - 0.2 9.2 0.1 0.26 8.7 0.1 1.0 1 0 0 1 1 1 0 Baculovirus DNA helicase zf-NADH-PPase PF09297.11 CCF36102.1 - 0.27 10.9 4.2 0.3 10.8 0.7 2.5 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain BAF1_ABF1 PF04684.13 CCF36102.1 - 2.5 7.1 10.8 3.5 6.6 10.8 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Zn_clus PF00172.18 CCF36103.1 - 5.5e-19 68.0 27.0 2e-10 40.6 7.0 2.5 2 0 0 2 2 2 2 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CCF36103.1 - 2e-10 40.2 0.1 3.3e-10 39.5 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain GFA PF04828.14 CCF36104.1 - 5.7e-13 49.0 0.3 5e-06 26.8 1.0 2.2 2 0 0 2 2 2 2 Glutathione-dependent formaldehyde-activating enzyme Glutaredoxin PF00462.24 CCF36106.1 - 2.1e-13 50.2 0.1 9.3e-13 48.2 0.0 2.2 2 0 0 2 2 2 1 Glutaredoxin NDUF_B4 PF07225.12 CCF36106.1 - 0.08 12.8 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4) Med16 PF11635.8 CCF36107.1 - 4.3e-80 269.6 0.0 5.9e-80 269.2 0.0 1.1 1 0 0 1 1 1 1 Mediator complex subunit 16 RhoGEF PF00621.20 CCF36108.1 - 1.1e-26 94.2 0.0 2e-26 93.4 0.0 1.4 1 0 0 1 1 1 1 RhoGEF domain DUF3507 PF12015.8 CCF36108.1 - 0.019 14.7 0.0 0.038 13.7 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3507) Dcc1 PF09724.9 CCF36109.1 - 4.1e-09 36.2 0.1 4.4e-09 36.1 0.1 1.1 1 0 0 1 1 1 1 Sister chromatid cohesion protein Dcc1 F-box-like PF12937.7 CCF36113.1 - 0.00045 20.1 0.0 0.0012 18.6 0.0 1.8 1 1 0 1 1 1 1 F-box-like Fungal_trans PF04082.18 CCF36114.1 - 1.6e-25 89.6 0.2 2.5e-25 89.0 0.2 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF36114.1 - 7.3e-08 32.4 8.9 1.4e-07 31.5 8.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sugar_tr PF00083.24 CCF36115.1 - 1.6e-99 333.8 15.1 1.9e-99 333.6 15.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF36115.1 - 5.5e-33 114.4 27.6 2.3e-24 86.0 8.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 CCF36115.1 - 1.7e-07 30.2 11.1 0.00015 20.4 0.9 2.4 2 0 0 2 2 2 2 MFS/sugar transport protein DUF3522 PF12036.8 CCF36115.1 - 0.16 12.2 4.8 0.61 10.3 0.1 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF3522) Shisa PF13908.6 CCF36116.1 - 0.002 18.4 0.0 0.0026 18.0 0.0 1.1 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator EphA2_TM PF14575.6 CCF36116.1 - 0.0022 18.8 0.0 0.0024 18.7 0.0 1.1 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain Adeno_E3_CR2 PF02439.15 CCF36116.1 - 0.03 14.1 3.6 0.047 13.5 3.6 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 TMEM52 PF14979.6 CCF36116.1 - 0.22 11.4 0.9 0.28 11.1 0.9 1.1 1 0 0 1 1 1 0 Transmembrane 52 RCR PF12273.8 CCF36116.1 - 0.22 12.2 0.3 0.22 12.2 0.3 2.0 1 1 1 2 2 2 0 Chitin synthesis regulation, resistance to Congo red CorA PF01544.18 CCF36117.1 - 1.9e-06 27.4 0.0 3.4e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein MRC1 PF09444.10 CCF36118.1 - 4.5e-43 147.3 20.1 4.5e-43 147.3 20.1 9.3 9 2 1 10 10 10 2 MRC1-like domain Pkinase PF00069.25 CCF36120.1 - 7.2e-19 68.2 0.0 1.2e-09 38.0 0.0 2.8 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCF36120.1 - 2e-08 33.8 0.0 0.003 16.9 0.0 2.6 4 0 0 4 4 4 2 Protein tyrosine kinase APH PF01636.23 CCF36120.1 - 8.3e-05 22.6 0.2 0.0049 16.8 0.0 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 CCF36120.1 - 0.013 14.8 0.0 0.29 10.4 0.0 2.5 3 0 0 3 3 3 0 Kinase-like Kdo PF06293.14 CCF36120.1 - 0.068 12.5 0.0 0.22 10.9 0.0 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Glyco_hydro_88 PF07470.13 CCF36121.1 - 5.6e-14 52.0 0.0 7e-14 51.7 0.0 1.0 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 Sugar_tr PF00083.24 CCF36124.1 - 4.4e-95 319.2 26.3 5.5e-95 318.9 26.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF36124.1 - 2.1e-22 79.5 61.1 2.1e-20 73.0 26.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Pam17 PF08566.10 CCF36124.1 - 0.082 12.8 0.2 0.22 11.4 0.2 1.7 1 0 0 1 1 1 0 Mitochondrial import protein Pam17 AA_permease_2 PF13520.6 CCF36125.1 - 2.4e-38 132.1 51.3 2.9e-38 131.8 51.3 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CCF36125.1 - 9.5e-23 80.5 41.5 1.4e-22 79.9 41.5 1.2 1 0 0 1 1 1 1 Amino acid permease DUF3754 PF12576.8 CCF36125.1 - 0.036 14.0 1.0 0.52 10.2 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3754) SYS1 PF09801.9 CCF36125.1 - 7.2 6.8 15.6 1.3 9.1 0.1 3.6 4 1 0 4 4 4 0 Integral membrane protein S linking to the trans Golgi network DUF4848 PF16140.5 CCF36127.1 - 0.12 11.9 0.1 17 4.8 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4848) Zip PF02535.22 CCF36130.1 - 0.15 11.2 5.1 0.19 10.9 5.1 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter Raftlin PF15250.6 CCF36130.1 - 0.6 8.8 10.2 0.73 8.5 10.2 1.0 1 0 0 1 1 1 0 Raftlin DTHCT PF08070.11 CCF36130.1 - 2.1 9.1 31.8 3.2 8.5 31.8 1.3 1 0 0 1 1 1 0 DTHCT (NUC029) region Dsh_C PF12316.8 CCF36130.1 - 5.3 7.4 8.8 8.1 6.8 8.8 1.4 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal RR_TM4-6 PF06459.12 CCF36130.1 - 5.7 6.7 12.7 6.8 6.4 12.7 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 XRN_M PF17846.1 CCF36130.1 - 6.7 5.6 12.5 7.5 5.4 12.5 1.0 1 0 0 1 1 1 0 Xrn1 helical domain Asn_synthase PF00733.21 CCF36131.1 - 2.1e-65 221.7 0.0 3e-65 221.2 0.0 1.1 1 0 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.6 CCF36131.1 - 7.3e-34 116.3 0.0 1.4e-33 115.4 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 CCF36131.1 - 4.7e-33 114.2 0.0 2e-32 112.2 0.0 2.0 2 0 0 2 2 2 1 Glutamine amidotransferase domain DUF3700 PF12481.8 CCF36131.1 - 4.7e-06 26.2 0.0 1.1e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 Aluminium induced protein tRNA_Me_trans PF03054.16 CCF36131.1 - 0.045 12.6 0.0 0.065 12.0 0.0 1.2 1 0 0 1 1 1 0 tRNA methyl transferase NAD_synthase PF02540.17 CCF36131.1 - 0.061 12.4 0.0 0.095 11.8 0.0 1.3 1 0 0 1 1 1 0 NAD synthase Sec10 PF07393.11 CCF36132.1 - 1.4e-31 109.7 0.0 1.7e-31 109.4 0.0 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec10 DUF5302 PF17227.2 CCF36132.1 - 0.0041 18.1 3.1 0.005 17.8 1.7 1.8 2 0 0 2 2 2 1 Family of unknown function (DUF5302) zf-C3HC4 PF00097.25 CCF36133.1 - 7.3e-08 32.2 12.1 1.4e-07 31.2 12.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CCF36133.1 - 1.5e-07 31.2 11.5 2.9e-07 30.2 11.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CCF36133.1 - 4e-07 29.8 8.9 8.4e-07 28.8 8.9 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 CCF36133.1 - 4.1e-07 29.8 10.0 5e-07 29.5 8.9 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CCF36133.1 - 6.6e-07 29.6 13.1 1.3e-06 28.6 13.1 1.5 1 0 0 1 1 1 1 Ring finger domain Helicase_C PF00271.31 CCF36133.1 - 0.00014 22.1 0.0 0.0003 21.1 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-RING_UBOX PF13445.6 CCF36133.1 - 0.00027 20.9 10.4 0.0008 19.4 10.4 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 CCF36133.1 - 0.00053 20.1 9.5 0.0013 18.8 9.5 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.7 CCF36133.1 - 0.00098 19.4 11.3 0.0027 18.0 11.3 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_4 PF14570.6 CCF36133.1 - 0.014 15.2 7.0 0.036 13.9 7.0 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_5 PF14634.6 CCF36133.1 - 0.029 14.3 11.0 0.071 13.1 11.0 1.7 1 1 0 1 1 1 0 zinc-RING finger domain DUF1244 PF06844.11 CCF36133.1 - 0.17 12.1 2.0 0.51 10.5 2.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1244) IBR PF01485.21 CCF36133.1 - 0.45 10.8 7.8 1.2 9.4 7.8 1.7 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain zf-RING_10 PF16685.5 CCF36133.1 - 0.55 10.4 5.5 1.2 9.3 5.5 1.5 1 0 0 1 1 1 0 zinc RING finger of MSL2 SlyX PF04102.12 CCF36133.1 - 8.1 7.2 7.9 71 4.1 0.1 4.2 4 0 0 4 4 3 0 SlyX Gin PF10764.9 CCF36133.1 - 8.6 6.4 7.2 1.7 8.6 3.5 1.8 2 0 0 2 2 1 0 Inhibitor of sigma-G Gin zf-P11 PF03854.14 CCF36133.1 - 9.4 6.0 11.4 2.4 7.9 8.0 1.8 2 0 0 2 2 2 0 P-11 zinc finger Arginase PF00491.21 CCF36134.1 - 4.4e-94 315.1 0.0 5.6e-94 314.8 0.0 1.0 1 0 0 1 1 1 1 Arginase family UPF0489 PF12640.7 CCF36134.1 - 0.032 14.4 0.8 0.062 13.5 0.3 1.7 1 1 1 2 2 2 0 UPF0489 domain Ras PF00071.22 CCF36136.1 - 1.3e-52 177.7 0.0 1.5e-52 177.5 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCF36136.1 - 5.4e-19 68.6 0.0 7.4e-19 68.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCF36136.1 - 1.3e-06 28.0 0.0 1.7e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Ecl1 PF12855.7 CCF36137.1 - 7.6e-39 134.7 18.8 7.6e-39 134.7 18.8 1.9 2 0 0 2 2 2 1 ECL1/2/3 zinc binding proteins zf-MYND PF01753.18 CCF36137.1 - 0.055 13.6 2.5 0.093 12.8 2.5 1.4 1 0 0 1 1 1 0 MYND finger PLATZ PF04640.14 CCF36137.1 - 0.076 13.6 1.0 0.13 12.9 1.0 1.4 1 0 0 1 1 1 0 PLATZ transcription factor zf-FLZ PF04570.14 CCF36137.1 - 0.084 12.4 3.3 0.2 11.2 3.3 1.5 1 1 0 1 1 1 0 zinc-finger of the FCS-type, C2-C2 DUF2256 PF10013.9 CCF36137.1 - 1.4 9.1 6.3 39 4.5 6.3 2.5 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2256) SIN1_PH PF16979.5 CCF36138.1 - 0.14 12.4 0.1 0.19 12.0 0.1 1.2 1 0 0 1 1 1 0 SAPK-interacting protein 1 (Sin1), Pleckstrin-homology Cwf_Cwc_15 PF04889.12 CCF36138.1 - 0.18 11.5 12.8 0.22 11.2 12.8 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Nop14 PF04147.12 CCF36138.1 - 0.86 7.7 12.3 1 7.5 12.3 1.1 1 0 0 1 1 1 0 Nop14-like family Pes-10 PF07149.11 CCF36138.1 - 1.2 8.2 7.5 1.8 7.5 7.5 1.4 1 0 0 1 1 1 0 Pes-10 NOA36 PF06524.12 CCF36138.1 - 1.5 8.0 11.6 2.1 7.6 11.6 1.2 1 0 0 1 1 1 0 NOA36 protein FMN_bind_2 PF04299.12 CCF36139.1 - 2.1e-58 196.8 0.0 2.4e-58 196.6 0.0 1.0 1 0 0 1 1 1 1 Putative FMN-binding domain RcnB PF11776.8 CCF36140.1 - 0.026 14.6 0.2 0.045 13.8 0.2 1.4 1 0 0 1 1 1 0 Nickel/cobalt transporter regulator HET PF06985.11 CCF36141.1 - 1.1e-23 84.2 0.1 8.4e-18 65.1 0.0 2.3 2 0 0 2 2 2 2 Heterokaryon incompatibility protein (HET) GFA PF04828.14 CCF36143.1 - 1.2e-09 38.3 0.1 1.2e-09 38.3 0.1 1.6 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme Ras PF00071.22 CCF36145.1 - 1.1e-51 174.6 0.0 2e-51 173.8 0.0 1.4 1 1 0 1 1 1 1 Ras family Roc PF08477.13 CCF36145.1 - 5.9e-18 65.2 0.0 8.2e-17 61.5 0.0 2.1 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCF36145.1 - 0.00052 19.5 0.0 0.0019 17.7 0.0 1.8 1 1 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 CCF36145.1 - 0.018 15.0 0.0 5.2 6.9 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase Abhydrolase_4 PF08386.10 CCF36145.1 - 0.032 14.4 0.0 0.076 13.1 0.0 1.6 1 0 0 1 1 1 0 TAP-like protein FeoB_N PF02421.18 CCF36145.1 - 0.049 13.2 0.1 0.6 9.6 0.0 2.2 2 1 0 2 2 2 0 Ferrous iron transport protein B AAA_16 PF13191.6 CCF36145.1 - 0.063 13.7 0.0 0.084 13.2 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain AAA_25 PF13481.6 CCF36145.1 - 0.14 11.8 0.0 0.23 11.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain Septin PF00735.18 CCF36145.1 - 0.19 10.9 0.0 0.4 9.9 0.0 1.5 2 0 0 2 2 2 0 Septin HlyIII PF03006.20 CCF36147.1 - 9.7e-54 182.4 14.7 1.3e-53 182.0 14.7 1.1 1 0 0 1 1 1 1 Haemolysin-III related Ycf66_N PF07444.11 CCF36147.1 - 0.019 15.1 2.2 0.25 11.5 0.6 2.6 2 0 0 2 2 2 0 Ycf66 protein N-terminus RhoGAP PF00620.27 CCF36151.1 - 1.1e-27 96.7 0.0 1.7e-27 96.1 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain RRS1 PF04939.12 CCF36152.1 - 1.8e-60 203.5 6.3 2.1e-60 203.3 6.3 1.0 1 0 0 1 1 1 1 Ribosome biogenesis regulatory protein (RRS1) DUF1244 PF06844.11 CCF36152.1 - 0.054 13.7 1.4 0.12 12.6 1.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1244) Dppa2_A PF14049.6 CCF36152.1 - 2.6 8.3 7.3 2.9 8.1 0.0 3.2 2 1 0 3 3 3 0 Dppa2/4 conserved region in higher vertebrates DAP3 PF10236.9 CCF36153.1 - 9.1e-72 241.9 0.0 8.5e-71 238.7 0.0 2.0 1 1 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 MCM PF00493.23 CCF36154.1 - 1.6e-104 347.9 0.4 2.8e-104 347.1 0.0 1.6 2 0 0 2 2 2 1 MCM P-loop domain MCM_OB PF17207.3 CCF36154.1 - 2.2e-28 98.6 0.6 3.8e-28 97.9 0.6 1.3 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 CCF36154.1 - 9e-21 74.1 0.7 2.1e-20 72.9 0.7 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 CCF36154.1 - 3.6e-19 69.3 2.0 4.5e-19 69.0 0.5 2.0 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.21 CCF36154.1 - 1.3e-07 31.2 0.0 1.5e-05 24.5 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 CCF36154.1 - 3.9e-06 26.9 0.0 1.4e-05 25.1 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_lid_2 PF17863.1 CCF36154.1 - 0.0032 17.3 0.1 0.012 15.5 0.1 1.9 1 0 0 1 1 1 1 AAA lid domain AAA_3 PF07726.11 CCF36154.1 - 0.015 15.1 0.0 0.05 13.5 0.0 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Mg_chelatase_C PF13335.6 CCF36154.1 - 0.049 14.3 1.6 0.17 12.5 0.2 2.6 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI C-terminal Sigma54_activat PF00158.26 CCF36154.1 - 0.16 11.7 0.0 0.93 9.2 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA PF00004.29 CCF36155.1 - 7.8e-54 181.7 0.0 3e-43 147.4 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) PEX-1N PF09262.11 CCF36155.1 - 6.3e-27 93.8 0.5 2.1e-26 92.2 0.2 2.1 2 0 0 2 2 1 1 Peroxisome biogenesis factor 1, N-terminal AAA_lid_3 PF17862.1 CCF36155.1 - 2.8e-14 52.6 0.2 2.2e-08 33.8 0.1 2.8 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 CCF36155.1 - 1.1e-10 42.2 4.0 0.00012 22.5 0.1 4.3 2 2 2 4 4 4 2 AAA ATPase domain NACHT PF05729.12 CCF36155.1 - 2e-07 31.1 0.3 0.00022 21.2 0.0 3.2 3 0 0 3 3 3 1 NACHT domain RuvB_N PF05496.12 CCF36155.1 - 4.5e-06 26.5 0.0 0.014 15.1 0.0 2.5 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain TsaE PF02367.17 CCF36155.1 - 9e-06 25.7 0.1 0.02 14.9 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE PEX-2N PF09263.10 CCF36155.1 - 1.6e-05 25.1 0.1 0.38 11.1 0.0 2.8 2 0 0 2 2 2 2 Peroxisome biogenesis factor 1, N-terminal TIP49 PF06068.13 CCF36155.1 - 3.6e-05 23.2 0.0 0.078 12.2 0.0 2.3 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_22 PF13401.6 CCF36155.1 - 3.8e-05 24.0 1.8 0.23 11.7 0.2 3.6 2 2 1 3 3 3 1 AAA domain AAA_33 PF13671.6 CCF36155.1 - 3.9e-05 23.8 0.0 0.26 11.5 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 CCF36155.1 - 9.4e-05 23.0 0.1 0.28 11.7 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_2 PF07724.14 CCF36155.1 - 0.0001 22.5 0.0 0.26 11.4 0.0 2.5 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 CCF36155.1 - 0.00013 21.9 0.1 0.6 10.1 0.0 3.0 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 CCF36155.1 - 0.00029 20.9 0.0 0.45 10.6 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_7 PF12775.7 CCF36155.1 - 0.00038 20.0 0.0 0.015 14.8 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_25 PF13481.6 CCF36155.1 - 0.00099 18.7 3.3 1.3 8.5 0.1 3.3 2 2 0 3 3 3 2 AAA domain Zeta_toxin PF06414.12 CCF36155.1 - 0.0031 16.8 0.1 1 8.6 0.0 2.5 2 0 0 2 2 2 1 Zeta toxin RNA_helicase PF00910.22 CCF36155.1 - 0.0039 17.6 0.0 5.1 7.5 0.0 2.6 2 0 0 2 2 2 1 RNA helicase IstB_IS21 PF01695.17 CCF36155.1 - 0.0042 16.8 0.2 3.5 7.3 0.0 2.4 2 0 0 2 2 2 2 IstB-like ATP binding protein Mg_chelatase PF01078.21 CCF36155.1 - 0.0084 15.5 0.5 0.79 9.1 0.1 2.8 3 0 0 3 3 2 1 Magnesium chelatase, subunit ChlI Cytidylate_kin2 PF13189.6 CCF36155.1 - 0.016 15.3 0.1 4.9 7.3 0.0 2.5 2 0 0 2 2 2 0 Cytidylate kinase-like family Sigma54_activ_2 PF14532.6 CCF36155.1 - 0.021 15.0 0.0 1.4 9.1 0.0 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain Sigma54_activat PF00158.26 CCF36155.1 - 0.033 13.9 0.0 2 8.1 0.0 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain Viral_helicase1 PF01443.18 CCF36155.1 - 0.035 13.8 0.0 4.3 7.0 0.0 2.5 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_28 PF13521.6 CCF36155.1 - 0.044 14.0 0.1 9.7 6.4 0.1 2.5 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.6 CCF36155.1 - 0.06 13.8 1.9 2.5 8.5 0.1 2.9 3 0 0 3 3 3 0 AAA domain Rad17 PF03215.15 CCF36155.1 - 0.074 13.0 0.0 4.5 7.1 0.0 2.3 2 0 0 2 2 2 0 Rad17 P-loop domain ATPase PF06745.13 CCF36155.1 - 0.09 12.1 0.0 13 5.1 0.0 2.4 2 0 0 2 2 2 0 KaiC DUF2075 PF09848.9 CCF36155.1 - 0.093 12.0 0.0 9 5.4 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_29 PF13555.6 CCF36155.1 - 0.093 12.5 0.0 1.6 8.5 0.1 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain ABC_tran PF00005.27 CCF36155.1 - 0.12 12.9 0.1 26 5.3 0.0 2.8 2 0 0 2 2 2 0 ABC transporter AAA_24 PF13479.6 CCF36155.1 - 0.16 11.7 0.2 19 4.9 0.1 2.3 2 0 0 2 2 2 0 AAA domain RPA_C PF08784.11 CCF36157.1 - 1.8e-20 73.5 0.1 5.1e-20 72.1 0.0 1.7 2 0 0 2 2 2 1 Replication protein A C terminal tRNA_anti-codon PF01336.25 CCF36157.1 - 2e-08 34.1 0.0 4e-08 33.1 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain RMI2 PF16100.5 CCF36157.1 - 0.032 14.1 0.0 0.057 13.2 0.0 1.3 1 0 0 1 1 1 0 RecQ-mediated genome instability protein 2 MarR_2 PF12802.7 CCF36157.1 - 0.072 13.0 0.0 0.21 11.5 0.0 1.8 2 0 0 2 2 2 0 MarR family Lon_C PF05362.13 CCF36158.1 - 2.7e-68 229.6 1.0 1.3e-67 227.3 0.6 2.0 2 0 0 2 2 2 1 Lon protease (S16) C-terminal proteolytic domain LON_substr_bdg PF02190.16 CCF36158.1 - 6.5e-27 94.8 0.0 1.4e-26 93.7 0.0 1.6 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain AAA PF00004.29 CCF36158.1 - 6.3e-23 81.7 0.0 1.6e-22 80.4 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ChlI PF13541.6 CCF36158.1 - 1.1e-08 35.0 0.2 8.4e-08 32.1 0.0 2.3 2 0 0 2 2 2 1 Subunit ChlI of Mg-chelatase AAA_5 PF07728.14 CCF36158.1 - 2.9e-07 30.6 0.0 8.2e-07 29.1 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 CCF36158.1 - 3.8e-06 26.8 0.0 9.5e-06 25.5 0.0 1.7 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_16 PF13191.6 CCF36158.1 - 6.4e-06 26.7 0.3 2.3e-05 24.8 0.1 2.1 1 1 1 2 2 2 1 AAA ATPase domain AAA_3 PF07726.11 CCF36158.1 - 0.00012 22.0 0.0 0.00027 20.8 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 CCF36158.1 - 0.00038 20.2 0.1 0.0012 18.6 0.0 1.8 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 CCF36158.1 - 0.00047 20.3 0.0 0.0022 18.2 0.0 2.1 2 1 0 2 2 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 CCF36158.1 - 0.00074 19.8 0.0 0.039 14.2 0.0 2.8 1 1 0 1 1 1 1 AAA domain TIP49 PF06068.13 CCF36158.1 - 0.0019 17.4 0.0 0.0037 16.5 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain NACHT PF05729.12 CCF36158.1 - 0.014 15.4 0.0 0.092 12.7 0.0 2.2 2 0 0 2 2 2 0 NACHT domain AAA_33 PF13671.6 CCF36158.1 - 0.014 15.6 0.0 0.035 14.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 CCF36158.1 - 0.021 15.4 0.0 0.056 14.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 CCF36158.1 - 0.029 14.3 0.1 0.11 12.4 0.0 2.0 2 0 0 2 2 1 0 RsgA GTPase Pilin_PilX PF11530.8 CCF36158.1 - 0.03 14.3 0.0 0.061 13.2 0.0 1.4 1 0 0 1 1 1 0 Minor type IV pilin, PilX AAA_25 PF13481.6 CCF36158.1 - 0.038 13.6 0.1 0.12 12.0 0.0 1.8 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 CCF36158.1 - 0.055 13.4 0.1 0.2 11.5 0.0 2.0 1 1 1 2 2 2 0 NTPase RNA_helicase PF00910.22 CCF36158.1 - 0.064 13.6 0.0 0.22 11.9 0.0 1.9 2 0 0 2 2 1 0 RNA helicase TsaE PF02367.17 CCF36158.1 - 0.077 13.0 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 CCF36158.1 - 0.12 12.4 0.0 0.58 10.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 CCF36158.1 - 0.16 11.3 0.2 0.35 10.2 0.2 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Asp-B-Hydro_N PF05279.11 CCF36158.1 - 0.17 11.9 4.6 0.4 10.7 4.6 1.5 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region AAA_23 PF13476.6 CCF36158.1 - 0.19 12.2 0.0 0.19 12.2 0.0 3.3 1 1 1 2 2 1 0 AAA domain AAA_11 PF13086.6 CCF36158.1 - 0.42 10.4 0.0 0.42 10.4 0.0 2.2 1 1 1 2 2 2 0 AAA domain SOAR PF16533.5 CCF36158.1 - 0.74 9.8 4.8 0.65 10.0 2.4 2.2 2 0 0 2 2 2 0 STIM1 Orai1-activating region Phage_holin_3_3 PF16083.5 CCF36159.1 - 0.022 14.9 0.0 0.028 14.5 0.0 1.1 1 0 0 1 1 1 0 LydA holin phage, holin superfamily III dsDNA_bind PF01984.20 CCF36159.1 - 0.34 11.2 2.2 0.33 11.2 0.2 1.8 1 1 1 2 2 2 0 Double-stranded DNA-binding domain Exo_endo_phos PF03372.23 CCF36160.1 - 7.4e-05 22.4 0.1 0.00022 20.8 0.1 1.8 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF3017 PF11222.8 CCF36162.1 - 0.016 15.4 7.4 0.069 13.4 3.1 2.8 1 1 0 2 2 2 0 Protein of unknown function (DUF3017) SoxG PF04268.12 CCF36163.1 - 0.24 11.5 0.0 0.3 11.2 0.0 1.1 1 0 0 1 1 1 0 Sarcosine oxidase, gamma subunit family MFS_1 PF07690.16 CCF36165.1 - 1.4e-42 145.9 37.0 1.4e-42 145.9 37.0 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF36165.1 - 7.6e-14 51.4 6.6 7.6e-14 51.4 6.6 2.3 2 0 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 CCF36165.1 - 1.5e-12 46.8 14.5 2.4e-12 46.1 14.5 1.3 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.20 CCF36165.1 - 0.00012 20.5 8.3 0.0026 16.1 4.4 2.4 2 0 0 2 2 2 2 Organic Anion Transporter Polypeptide (OATP) family HpcH_HpaI PF03328.14 CCF36166.1 - 3.3e-45 153.9 0.0 6.6e-45 152.9 0.0 1.5 2 0 0 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family C-C_Bond_Lyase PF15617.6 CCF36166.1 - 2.1e-12 46.9 0.0 5.5e-06 25.8 0.0 2.1 2 0 0 2 2 2 2 C-C_Bond_Lyase of the TIM-Barrel fold PK PF00224.21 CCF36166.1 - 0.0066 15.4 0.0 0.0093 14.9 0.0 1.2 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain Mg_trans_NIPA PF05653.14 CCF36168.1 - 2.8e-42 144.8 3.1 5.9e-39 133.9 1.0 2.0 2 0 0 2 2 2 2 Magnesium transporter NIPA EamA PF00892.20 CCF36168.1 - 0.0011 19.1 1.9 0.0011 19.1 1.9 3.3 3 1 0 3 3 3 1 EamA-like transporter family DUF4231 PF14015.6 CCF36168.1 - 0.003 18.0 1.6 5.4 7.5 0.2 3.3 2 1 1 3 3 3 2 Protein of unknown function (DUF4231) Pox_A14 PF05767.12 CCF36168.1 - 0.54 10.4 7.3 1 9.5 2.2 2.7 2 1 1 3 3 3 0 Poxvirus virion envelope protein A14 VMA21 PF09446.10 CCF36168.1 - 1 9.5 7.0 0.11 12.6 2.1 1.9 2 0 0 2 2 2 0 VMA21-like domain SLC35F PF06027.12 CCF36168.1 - 1.6 8.2 7.0 0.2 11.2 1.5 2.1 2 1 1 3 3 3 0 Solute carrier family 35 DUF2976 PF11190.8 CCF36168.1 - 8.9 6.2 7.8 6.7 6.6 0.6 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2976) SLAC1 PF03595.17 CCF36169.1 - 1e-83 281.3 49.8 1.2e-83 281.1 49.8 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel TMEM192 PF14802.6 CCF36169.1 - 4 6.5 4.9 53 2.8 4.9 2.3 1 1 0 1 1 1 0 TMEM192 family CAP_N PF01213.19 CCF36170.1 - 4.6 6.6 5.1 4 6.8 5.1 1.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Actin PF00022.19 CCF36171.1 - 5.2e-14 51.7 0.0 8.4e-13 47.7 0.0 2.1 2 0 0 2 2 2 1 Actin FtsA PF14450.6 CCF36171.1 - 0.063 13.7 0.0 0.11 12.9 0.0 1.7 1 1 0 1 1 1 0 Cell division protein FtsA Borrelia_P83 PF05262.11 CCF36171.1 - 1.2 7.5 3.1 1.8 7.0 3.1 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein Ysc84 PF04366.12 CCF36172.1 - 1.3e-31 109.0 0.0 2.4e-31 108.1 0.0 1.5 1 0 0 1 1 1 1 Las17-binding protein actin regulator Cwf_Cwc_15 PF04889.12 CCF36172.1 - 0.86 9.3 9.2 1.9 8.2 9.2 1.6 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Acyl_transf_3 PF01757.22 CCF36173.1 - 1.2e-22 80.5 32.1 2.4e-22 79.4 32.1 1.5 1 1 0 1 1 1 1 Acyltransferase family Gtr1_RagA PF04670.12 CCF36174.1 - 1.3e-93 312.7 0.0 1.7e-93 312.3 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Roc PF08477.13 CCF36174.1 - 1.1e-07 32.1 0.0 2.2e-07 31.1 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 CCF36174.1 - 2.1e-07 30.7 0.1 4.2e-07 29.7 0.1 1.5 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.23 CCF36174.1 - 2.5e-07 30.8 0.0 4.3e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.21 CCF36174.1 - 1.5e-06 27.8 0.0 2.2e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 CCF36174.1 - 0.0011 18.1 2.9 0.94 8.6 0.6 2.9 2 1 1 3 3 3 2 G-protein alpha subunit ABC_tran PF00005.27 CCF36174.1 - 0.0035 17.9 0.3 0.014 15.9 0.0 2.1 2 1 0 2 2 2 1 ABC transporter AAA_29 PF13555.6 CCF36174.1 - 0.0038 17.0 0.9 0.054 13.2 0.2 2.3 2 0 0 2 2 2 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CCF36174.1 - 0.006 16.5 0.2 0.26 11.2 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase DUF815 PF05673.13 CCF36174.1 - 0.021 14.0 0.1 0.05 12.8 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_7 PF12775.7 CCF36174.1 - 0.038 13.5 0.0 0.47 9.9 0.0 2.1 2 0 0 2 2 2 0 P-loop containing dynein motor region SEP PF08059.13 CCF36175.1 - 1.8e-23 82.9 0.3 3.6e-23 81.9 0.0 1.7 2 0 0 2 2 2 1 SEP domain UBX PF00789.20 CCF36175.1 - 3.8e-11 43.0 0.0 6e-11 42.4 0.0 1.3 1 0 0 1 1 1 1 UBX domain UBA_4 PF14555.6 CCF36175.1 - 4e-11 42.5 0.1 7.3e-11 41.7 0.1 1.4 1 0 0 1 1 1 1 UBA-like domain TAP_C PF03943.13 CCF36175.1 - 0.00049 19.7 0.0 0.00086 18.9 0.0 1.4 1 0 0 1 1 1 1 TAP C-terminal domain TOM13 PF08219.11 CCF36176.1 - 3.5e-36 123.0 0.0 4.6e-36 122.7 0.0 1.1 1 0 0 1 1 1 1 Outer membrane protein TOM13 p450 PF00067.22 CCF36177.1 - 4.1e-43 147.8 0.0 4.8e-43 147.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Trp_DMAT PF11991.8 CCF36178.1 - 1.2e-98 330.9 0.0 1.4e-98 330.7 0.0 1.0 1 0 0 1 1 1 1 Tryptophan dimethylallyltransferase p450 PF00067.22 CCF36180.1 - 1.2e-49 169.4 0.0 1.6e-49 168.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 CCF36181.1 - 7e-19 67.9 0.0 1.1e-18 67.3 0.0 1.3 1 0 0 1 1 1 1 Cytochrome P450 ZnuA PF01297.17 CCF36183.1 - 0.022 14.2 0.2 0.044 13.2 0.1 1.5 2 0 0 2 2 2 0 Zinc-uptake complex component A periplasmic RRM_1 PF00076.22 CCF36184.1 - 7.7e-19 67.3 0.1 1.1e-11 44.3 0.0 3.9 3 1 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CCF36184.1 - 0.0033 17.5 0.1 0.15 12.2 0.2 2.5 2 0 0 2 2 2 1 RNA recognition motif Nup35_RRM_2 PF14605.6 CCF36184.1 - 0.052 13.5 0.0 0.13 12.3 0.0 1.7 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Peptidase_S28 PF05577.12 CCF36185.1 - 6e-49 167.0 0.0 7.7e-48 163.4 0.0 2.0 1 1 0 1 1 1 1 Serine carboxypeptidase S28 GMC_oxred_N PF00732.19 CCF36186.1 - 4.2e-49 167.5 0.0 5.4e-49 167.2 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCF36186.1 - 9.7e-38 129.9 0.0 1.7e-37 129.2 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.12 CCF36186.1 - 0.00033 19.8 0.1 0.0008 18.6 0.0 1.6 2 0 0 2 2 2 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 CCF36186.1 - 0.0034 17.6 0.1 0.0084 16.3 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CCF36186.1 - 0.0039 16.5 0.1 0.0099 15.1 0.1 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCF36186.1 - 0.054 13.1 1.9 0.061 12.9 0.6 1.7 2 0 0 2 2 2 0 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CCF36186.1 - 0.089 11.9 1.1 0.14 11.2 1.1 1.3 1 0 0 1 1 1 0 FAD binding domain HHH PF00633.23 CCF36186.1 - 0.11 12.4 0.0 0.31 11.0 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix motif Thi4 PF01946.17 CCF36186.1 - 0.13 11.5 0.1 0.22 10.7 0.1 1.3 1 0 0 1 1 1 0 Thi4 family HHH_5 PF14520.6 CCF36186.1 - 0.17 12.5 0.8 0.5 11.0 0.1 1.9 2 0 0 2 2 2 0 Helix-hairpin-helix domain PS-DH PF14765.6 CCF36189.1 - 2.7e-44 151.6 0.1 5.6e-44 150.6 0.1 1.5 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 CCF36189.1 - 2.8e-44 151.9 0.0 6.6e-44 150.7 0.0 1.6 1 1 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 CCF36189.1 - 1.6e-38 131.3 0.2 6.1e-38 129.5 0.1 2.2 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 CCF36189.1 - 1e-17 64.6 0.0 5.8e-17 62.2 0.0 2.4 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension ADH_zinc_N PF00107.26 CCF36189.1 - 1.2e-14 54.4 0.0 4.6e-14 52.5 0.0 2.0 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ketoacyl-synt PF00109.26 CCF36189.1 - 1.2e-13 51.2 0.2 2.4e-13 50.3 0.2 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain ADH_zinc_N_2 PF13602.6 CCF36189.1 - 5.2e-10 40.5 0.0 1.6e-09 38.9 0.0 1.9 1 0 0 1 1 1 1 Zinc-binding dehydrogenase KR PF08659.10 CCF36189.1 - 2.3e-09 37.4 0.4 7.7e-09 35.7 0.4 2.0 1 0 0 1 1 1 1 KR domain ADH_N PF08240.12 CCF36189.1 - 2.5e-05 24.1 0.4 6.7e-05 22.7 0.4 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain adh_short PF00106.25 CCF36189.1 - 0.0062 16.0 0.4 0.023 14.1 0.1 2.3 2 0 0 2 2 2 1 short chain dehydrogenase ThiF PF00899.21 CCF36189.1 - 0.061 12.7 0.0 0.13 11.6 0.0 1.5 1 0 0 1 1 1 0 ThiF family Yippee-Mis18 PF03226.14 CCF36190.1 - 1.5e-11 44.5 0.0 2e-11 44.0 0.0 1.2 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Nop14 PF04147.12 CCF36190.1 - 2.5 6.2 5.9 2.3 6.3 5.9 1.0 1 0 0 1 1 1 0 Nop14-like family Peptidase_M20 PF01546.28 CCF36191.1 - 1.1e-33 116.7 0.0 1.6e-33 116.2 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 CCF36191.1 - 2.6e-13 49.8 0.0 4.3e-13 49.1 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 CCF36191.1 - 0.038 13.7 0.0 0.067 12.9 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M28 DWNN PF08783.11 CCF36192.1 - 5.8e-31 106.6 0.0 1e-30 105.8 0.0 1.4 1 0 0 1 1 1 1 DWNN domain zf-CCHC_2 PF13696.6 CCF36192.1 - 1.7e-08 34.1 5.5 1.7e-08 34.1 5.5 1.6 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC PF00098.23 CCF36192.1 - 0.00049 20.0 0.9 0.0012 18.8 0.9 1.7 1 0 0 1 1 1 1 Zinc knuckle zf-C3HC4_2 PF13923.6 CCF36192.1 - 0.0021 17.8 10.5 0.0021 17.8 10.5 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) DUF3332 PF11810.8 CCF36192.1 - 0.019 14.6 1.5 0.037 13.7 1.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3332) zf-RING_6 PF14835.6 CCF36192.1 - 0.055 13.3 1.6 0.094 12.6 1.6 1.3 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_2 PF13639.6 CCF36192.1 - 0.062 13.6 7.6 0.14 12.5 7.6 1.6 1 0 0 1 1 1 0 Ring finger domain zf-Nse PF11789.8 CCF36192.1 - 0.065 13.1 6.5 0.24 11.3 6.6 1.8 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit DUF966 PF06136.13 CCF36192.1 - 0.81 9.3 9.1 0.23 11.2 1.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF966) FYVE_2 PF02318.16 CCF36192.1 - 1.3 9.2 5.3 0.22 11.8 1.0 1.9 3 0 0 3 3 1 0 FYVE-type zinc finger zf-C3HC4_4 PF15227.6 CCF36192.1 - 1.9 8.7 11.0 4.6 7.5 11.0 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING SOBP PF15279.6 CCF36192.1 - 2.1 8.9 26.2 2.2 8.8 17.4 2.2 2 0 0 2 2 2 0 Sine oculis-binding protein zf-RING_UBOX PF13445.6 CCF36192.1 - 2.2 8.4 7.5 4.4 7.4 7.5 1.5 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4 PF00097.25 CCF36192.1 - 3.9 7.4 11.6 7.5 6.5 11.6 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF1272 PF06906.11 CCF36192.1 - 4.5 7.4 8.9 0.63 10.2 3.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1272) zf-C2H2 PF00096.26 CCF36193.1 - 0.21 12.1 3.3 0.36 11.4 3.3 1.4 1 0 0 1 1 1 0 Zinc finger, C2H2 type p450 PF00067.22 CCF36194.1 - 4.3e-53 180.7 0.0 4.9e-53 180.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Antimicrobial20 PF08256.11 CCF36194.1 - 0.2 12.2 2.2 0.92 10.2 2.2 2.2 1 0 0 1 1 1 0 Aurein-like antibiotic peptide CBM_21 PF03370.13 CCF36195.1 - 1e-32 112.6 0.0 1.6e-32 112.0 0.0 1.3 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.5 CCF36195.1 - 7.9e-10 39.2 0.1 1.7e-09 38.1 0.1 1.5 1 0 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) Nramp PF01566.18 CCF36196.1 - 1.7e-81 274.0 26.6 1.7e-81 274.0 26.6 2.5 2 1 0 2 2 2 1 Natural resistance-associated macrophage protein BRAP2 PF07576.12 CCF36197.1 - 4.3e-30 103.9 0.0 8.2e-30 103.0 0.0 1.4 1 0 0 1 1 1 1 BRCA1-associated protein 2 zf-UBP PF02148.19 CCF36197.1 - 1.6e-19 70.0 6.2 9.4e-19 67.5 5.0 2.4 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein zf-RING_2 PF13639.6 CCF36197.1 - 8.4e-09 35.6 9.6 8.4e-09 35.6 9.6 2.3 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 CCF36197.1 - 5.3e-07 29.4 9.8 1.3e-06 28.1 9.8 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 CCF36197.1 - 1.2e-06 28.1 4.8 4.8e-06 26.2 4.8 2.2 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4 PF00097.25 CCF36197.1 - 3e-06 27.0 8.1 8.3e-06 25.6 8.1 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CCF36197.1 - 2.6e-05 24.2 3.6 2.6e-05 24.2 3.6 2.5 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 CCF36197.1 - 0.00011 22.1 8.5 0.00011 22.1 8.5 1.9 2 0 0 2 2 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 CCF36197.1 - 0.00014 21.7 6.9 0.00014 21.7 6.9 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 CCF36197.1 - 0.00033 20.9 6.7 0.001 19.3 6.7 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 CCF36197.1 - 0.0048 16.7 11.2 0.0048 16.7 11.2 2.9 2 1 1 3 3 2 1 Prokaryotic RING finger family 4 zf-RING_6 PF14835.6 CCF36197.1 - 0.0054 16.6 3.2 0.014 15.2 3.2 1.7 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-ANAPC11 PF12861.7 CCF36197.1 - 0.11 12.6 7.3 0.28 11.3 7.3 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.6 CCF36197.1 - 0.24 11.2 6.9 0.54 10.1 6.9 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain FAA_hydro_N_2 PF18288.1 CCF36197.1 - 0.44 11.0 3.2 0.7 10.4 0.2 2.6 1 1 1 2 2 2 0 Fumarylacetoacetase N-terminal domain 2 zf-UBP_var PF17807.1 CCF36197.1 - 1.8 8.4 4.8 0.37 10.6 0.3 2.1 2 0 0 2 2 2 0 Variant UBP zinc finger Rtf2 PF04641.12 CCF36197.1 - 2.5 7.4 12.8 0.048 13.0 0.5 2.4 2 0 0 2 2 2 0 Rtf2 RING-finger ubiquitin PF00240.23 CCF36198.1 - 4.5e-41 138.5 2.5 2.4e-34 116.9 0.6 2.0 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 CCF36198.1 - 1.3e-18 66.6 0.6 1.5e-16 59.9 0.7 2.0 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 CCF36198.1 - 5.7e-07 29.9 0.5 3.9e-05 24.0 0.1 2.7 2 1 0 2 2 2 1 Ubiquitin-like domain Ubiquitin_5 PF18037.1 CCF36198.1 - 0.00093 19.5 0.2 0.0011 19.3 0.2 1.2 1 0 0 1 1 1 1 Ubiquitin-like domain Ubiquitin_4 PF18036.1 CCF36198.1 - 0.0011 18.9 1.1 2.5 8.2 0.1 2.9 3 0 0 3 3 3 2 Ubiquitin-like domain TBK1_ULD PF18396.1 CCF36198.1 - 0.0021 18.0 0.0 0.0026 17.6 0.0 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 CCF36198.1 - 0.004 17.2 0.1 0.012 15.7 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Sde2_N_Ubi PF13019.6 CCF36198.1 - 0.0042 16.9 0.2 0.037 13.9 0.0 1.9 1 1 1 2 2 2 1 Silencing defective 2 N-terminal ubiquitin domain DUF2407 PF10302.9 CCF36198.1 - 0.03 14.9 0.1 0.04 14.5 0.1 1.2 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Methyltrans_RNA PF04452.14 CCF36198.1 - 0.098 12.0 0.1 0.16 11.2 0.0 1.4 2 0 0 2 2 2 0 RNA methyltransferase Nfu_N PF08712.11 CCF36199.1 - 5.2e-29 100.1 0.1 2.3e-28 98.0 0.0 2.1 2 0 0 2 2 2 1 Scaffold protein Nfu/NifU N terminal NifU PF01106.17 CCF36199.1 - 5.4e-27 93.7 0.1 9.2e-27 93.0 0.1 1.4 1 0 0 1 1 1 1 NifU-like domain PSP1 PF04468.12 CCF36202.1 - 9e-28 96.4 1.3 9e-28 96.4 1.3 2.0 3 0 0 3 3 3 1 PSP1 C-terminal conserved region DUF2722 PF10846.8 CCF36202.1 - 0.00056 19.0 3.1 0.00056 19.0 3.1 3.1 3 0 0 3 3 3 2 Protein of unknown function (DUF2722) Spt20 PF12090.8 CCF36202.1 - 0.14 11.7 33.8 0.19 11.3 5.2 3.1 3 0 0 3 3 3 0 Spt20 family Suf PF05843.14 CCF36202.1 - 0.53 10.2 15.8 1.1 9.2 1.4 3.4 3 0 0 3 3 3 0 Suppressor of forked protein (Suf) DUF4834 PF16118.5 CCF36202.1 - 1.4 9.9 16.6 0.16 13.0 1.4 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) ANAPC_CDC26 PF10471.9 CCF36202.1 - 3.6 8.5 34.1 2.2 9.2 6.3 3.8 3 0 0 3 3 3 0 Anaphase-promoting complex APC subunit CDC26 TFIIA PF03153.13 CCF36204.1 - 3.5 7.5 8.3 7.5 6.4 8.3 1.5 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4078 PF13300.6 CCF36205.1 - 7.8e-27 93.4 19.3 7.8e-27 93.4 19.3 2.3 3 0 0 3 3 3 1 Domain of unknown function (DUF4078) MCRS_N PF13325.6 CCF36205.1 - 0.3 11.1 4.3 0.49 10.4 4.3 1.2 1 0 0 1 1 1 0 N-terminal region of micro-spherule protein Ydc2-catalyt PF09159.10 CCF36205.1 - 0.38 10.4 6.2 0.05 13.3 1.8 1.8 1 1 1 2 2 2 0 Mitochondrial resolvase Ydc2 / RNA splicing MRS1 DUF2407_C PF13373.6 CCF36205.1 - 0.45 10.7 5.3 0.51 10.5 0.5 2.3 2 0 0 2 2 2 0 DUF2407 C-terminal domain Amidohydro_2 PF04909.14 CCF36206.1 - 9.2e-31 107.7 0.6 1.1e-30 107.5 0.6 1.0 1 0 0 1 1 1 1 Amidohydrolase Cutinase PF01083.22 CCF36207.1 - 3.9e-29 101.9 0.0 6.4e-29 101.2 0.0 1.3 1 0 0 1 1 1 1 Cutinase PE-PPE PF08237.11 CCF36207.1 - 0.083 12.4 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 PE-PPE domain Abhydrolase_2 PF02230.16 CCF36207.1 - 0.098 12.5 0.0 0.15 11.9 0.0 1.2 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Abhydrolase_3 PF07859.13 CCF36207.1 - 0.15 11.9 0.1 0.24 11.2 0.1 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold TFIIF_alpha PF05793.12 CCF36209.1 - 6e-06 25.1 63.7 6e-06 25.1 63.7 1.9 1 1 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Bud13 PF09736.9 CCF36210.1 - 8.5e-50 168.9 7.9 8.5e-50 168.9 7.9 2.0 3 0 0 3 3 3 1 Pre-mRNA-splicing factor of RES complex Cation_efflux PF01545.21 CCF36212.1 - 2.1e-12 47.2 11.8 2.9e-12 46.8 11.8 1.1 1 0 0 1 1 1 1 Cation efflux family Oleosin PF01277.17 CCF36212.1 - 0.2 11.4 1.5 1.8 8.4 0.4 2.6 2 1 1 3 3 3 0 Oleosin PIG-Y PF15159.6 CCF36213.1 - 7.5e-23 81.2 9.4 1.1e-22 80.7 9.4 1.3 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y DUF1218 PF06749.12 CCF36213.1 - 0.041 14.4 2.6 0.68 10.5 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1218) p450 PF00067.22 CCF36215.1 - 3.3e-13 49.2 0.0 9.8e-07 27.9 0.0 2.2 2 0 0 2 2 2 2 Cytochrome P450 DUF2975 PF11188.8 CCF36218.1 - 0.052 13.4 0.5 0.056 13.3 0.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2975) Aldo_ket_red PF00248.21 CCF36219.1 - 1.2e-50 172.4 0.0 1.3e-50 172.3 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Ribonuclease PF00545.20 CCF36220.1 - 3.7e-09 37.2 0.4 7.9e-09 36.2 0.0 1.6 1 1 1 2 2 2 1 ribonuclease DUF3602 PF12223.8 CCF36221.1 - 1.8e-13 50.9 4.8 2.5e-10 40.8 1.4 2.6 2 1 1 3 3 3 2 Protein of unknown function (DUF3602) URO-D PF01208.17 CCF36222.1 - 7.3e-111 370.7 0.0 8.9e-111 370.4 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) Fungal_trans_2 PF11951.8 CCF36226.1 - 0.13 11.1 0.0 0.19 10.5 0.0 1.2 1 0 0 1 1 1 0 Fungal specific transcription factor domain NAD_binding_10 PF13460.6 CCF36227.1 - 0.00056 19.9 0.0 0.00073 19.5 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 CCF36227.1 - 0.084 12.0 0.0 0.13 11.4 0.0 1.4 1 0 0 1 1 1 0 Male sterility protein DUF4410 PF14366.6 CCF36228.1 - 2.5 8.0 7.9 0.11 12.5 2.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4410) Comm PF15957.5 CCF36229.1 - 0.0025 18.2 0.0 0.0039 17.5 0.0 1.2 1 0 0 1 1 1 1 Commissureless HET PF06985.11 CCF36230.1 - 1.4e-27 96.9 0.0 2.9e-27 95.8 0.0 1.6 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) adh_short PF00106.25 CCF36232.1 - 7.3e-35 120.2 1.0 1.6e-22 79.9 0.1 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCF36232.1 - 1.9e-33 115.9 0.0 2.9e-17 63.0 0.0 2.3 2 1 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF36232.1 - 1.7e-10 41.1 0.4 7.1e-10 39.1 0.4 2.0 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF36232.1 - 0.00061 19.3 0.3 0.013 15.0 0.1 2.1 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CCF36232.1 - 0.048 12.7 0.1 0.081 11.9 0.1 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Imm74 PF15603.6 CCF36232.1 - 0.048 13.9 0.0 0.15 12.2 0.0 1.8 2 0 0 2 2 2 0 Immunity protein 74 Polysacc_synt_2 PF02719.15 CCF36232.1 - 0.12 11.4 0.0 0.18 10.9 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein KH_1 PF00013.29 CCF36233.1 - 2.4e-47 158.6 15.5 7.9e-17 60.8 0.8 3.3 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 CCF36233.1 - 2e-12 46.8 1.8 0.0042 16.9 0.0 3.3 3 0 0 3 3 3 3 KH domain KH_4 PF13083.6 CCF36233.1 - 3.8e-08 33.1 6.5 0.16 11.9 0.1 3.3 3 0 0 3 3 3 3 KH domain MOEP19 PF16005.5 CCF36233.1 - 0.002 18.1 0.0 0.2 11.7 0.0 2.9 3 0 0 3 3 3 1 KH-like RNA-binding domain KH_5 PF13184.6 CCF36233.1 - 0.0099 16.0 5.9 10 6.3 0.1 3.7 3 1 0 3 3 3 3 NusA-like KH domain HMGL-like PF00682.19 CCF36234.1 - 2.5e-39 135.4 0.0 1.7e-38 132.7 0.0 1.9 1 1 0 1 1 1 1 HMGL-like DUF362 PF04015.12 CCF36234.1 - 0.13 12.5 0.0 0.24 11.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF362) ATP-synt_ab PF00006.25 CCF36235.1 - 2e-65 220.4 0.0 3.5e-65 219.7 0.0 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 CCF36235.1 - 7.6e-15 55.2 1.0 1.7e-14 54.0 1.0 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain DUF5535 PF17687.1 CCF36235.1 - 0.038 14.1 0.1 0.094 12.9 0.1 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5535) DUF561 PF04481.12 CCF36235.1 - 0.17 11.0 0.0 0.27 10.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF561) ADH_N PF08240.12 CCF36236.1 - 4.2e-30 103.8 1.6 7e-30 103.1 1.6 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCF36236.1 - 7.9e-16 58.2 0.0 1.2e-15 57.6 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 CCF36236.1 - 3.4e-07 30.0 0.0 5.3e-07 29.3 0.0 1.2 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_N_assoc PF13823.6 CCF36236.1 - 6e-05 22.9 0.0 0.00013 21.8 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-associated ADH_zinc_N_2 PF13602.6 CCF36236.1 - 0.00024 22.2 0.0 0.00038 21.5 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 CCF36236.1 - 0.013 14.8 0.0 0.056 12.7 0.0 1.8 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Sen15 PF09631.10 CCF36237.1 - 1.9e-25 89.1 0.0 4.1e-25 88.0 0.0 1.6 1 1 0 1 1 1 1 Sen15 protein Fungal_trans PF04082.18 CCF36239.1 - 4.3e-12 45.6 0.0 7.3e-12 44.9 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Med22 PF06179.12 CCF36241.1 - 4.4e-06 26.8 0.1 5e-06 26.7 0.1 1.1 1 0 0 1 1 1 1 Surfeit locus protein 5 subunit 22 of Mediator complex HLH PF00010.26 CCF36242.1 - 1.3e-15 57.1 0.0 2.4e-15 56.2 0.0 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain YabA PF06156.13 CCF36242.1 - 0.037 14.6 0.1 0.081 13.6 0.1 1.6 1 0 0 1 1 1 0 Initiation control protein YabA ZapB PF06005.12 CCF36242.1 - 0.038 14.4 1.8 0.11 13.0 1.8 1.7 1 0 0 1 1 1 0 Cell division protein ZapB bZIP_1 PF00170.21 CCF36242.1 - 0.054 13.6 1.2 0.11 12.6 1.2 1.5 1 0 0 1 1 1 0 bZIP transcription factor Nnf1 PF03980.14 CCF36242.1 - 0.056 13.8 1.3 0.14 12.6 1.3 1.7 1 0 0 1 1 1 0 Nnf1 DivIC PF04977.15 CCF36242.1 - 0.16 11.8 2.2 0.41 10.5 2.2 1.7 1 0 0 1 1 1 0 Septum formation initiator DUF5094 PF17015.5 CCF36242.1 - 2.6 8.1 5.0 5.4 7.1 5.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF5094) Ndc1_Nup PF09531.10 CCF36242.1 - 8.8 4.9 11.5 11 4.6 11.5 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup NUDIX PF00293.28 CCF36246.1 - 2.5e-08 34.0 0.1 6e-08 32.8 0.0 1.6 2 0 0 2 2 2 1 NUDIX domain DUF4743 PF15916.5 CCF36246.1 - 0.0086 16.0 0.0 0.014 15.3 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4743) Pmp3 PF01679.17 CCF36247.1 - 0.081 13.1 0.1 0.13 12.5 0.1 1.6 1 1 0 1 1 1 0 Proteolipid membrane potential modulator SnoaL_2 PF12680.7 CCF36248.1 - 3e-12 47.1 0.1 3.8e-12 46.8 0.1 1.1 1 0 0 1 1 1 1 SnoaL-like domain SnoaL PF07366.12 CCF36248.1 - 2.3e-08 33.9 0.5 9.6e-07 28.6 0.5 2.0 1 1 0 1 1 1 1 SnoaL-like polyketide cyclase BRCT PF00533.26 CCF36252.1 - 0.0015 18.9 0.0 0.0031 17.9 0.0 1.6 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain RTT107_BRCT_5 PF16770.5 CCF36252.1 - 0.017 15.0 0.0 0.037 13.9 0.0 1.6 1 0 0 1 1 1 0 Regulator of Ty1 transposition protein 107 BRCT domain BRCT_3 PF18428.1 CCF36252.1 - 0.032 14.3 0.0 8.4 6.5 0.0 2.6 2 0 0 2 2 2 0 BRCA1 C Terminus (BRCT) domain MCM2_N PF12619.8 CCF36252.1 - 0.39 11.0 4.4 0.38 11.0 2.3 2.0 2 0 0 2 2 2 0 Mini-chromosome maintenance protein 2 tRNA-synt_2b PF00587.25 CCF36255.1 - 6.5e-38 130.5 0.0 1e-37 129.9 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 CCF36255.1 - 1.4e-14 54.2 6.7 3.1e-14 53.1 6.7 1.6 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain Vfa1 PF08432.10 CCF36255.1 - 0.051 13.9 7.8 0.089 13.1 7.8 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 TPR_12 PF13424.6 CCF36256.1 - 2.1e-06 27.9 1.0 9.5e-05 22.6 0.1 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 CCF36256.1 - 1e-05 24.9 5.5 2.2e-05 23.8 0.1 3.2 3 1 0 3 3 3 1 SHNi-TPR TPR_1 PF00515.28 CCF36256.1 - 0.00019 21.1 1.0 0.00065 19.4 1.0 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 CCF36256.1 - 0.0004 20.3 1.3 0.0004 20.3 1.3 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 CCF36256.1 - 0.0007 20.2 0.7 0.016 15.9 0.1 3.1 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_3 PF07720.12 CCF36256.1 - 0.28 11.2 2.0 0.83 9.7 1.4 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat p450 PF00067.22 CCF36258.1 - 2.4e-57 194.7 0.2 2.2e-56 191.6 0.2 1.9 1 1 0 1 1 1 1 Cytochrome P450 Amidohydro_1 PF01979.20 CCF36259.1 - 9.3e-19 67.9 0.1 1.9e-18 66.9 0.1 1.5 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 CCF36259.1 - 5.1e-12 46.0 0.2 9.9e-06 25.3 0.0 2.3 2 0 0 2 2 2 2 Amidohydrolase family TPP_enzyme_M PF00205.22 CCF36259.1 - 0.003 17.3 0.0 3.6 7.3 0.0 2.6 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, central domain Caps_synth PF05704.12 CCF36262.1 - 2.9e-11 43.3 0.0 4.6e-11 42.6 0.0 1.2 1 0 0 1 1 1 1 Capsular polysaccharide synthesis protein Gly_transf_sug PF04488.15 CCF36262.1 - 6.4e-05 23.5 0.1 0.00018 22.1 0.1 1.7 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Docking PF08990.11 CCF36262.1 - 0.0039 16.8 0.0 0.0087 15.7 0.0 1.6 1 0 0 1 1 1 1 Erythronolide synthase docking PqqD PF05402.12 CCF36262.1 - 0.19 12.1 0.1 0.93 9.8 0.1 2.2 2 0 0 2 2 2 0 Coenzyme PQQ synthesis protein D (PqqD) p450 PF00067.22 CCF36263.1 - 1.1e-37 130.0 0.0 1.3e-37 129.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Hydrolase_4 PF12146.8 CCF36263.1 - 0.15 11.3 0.8 0.98 8.6 0.2 2.3 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Methyltransf_2 PF00891.18 CCF36264.1 - 5.2e-24 84.7 0.0 8.6e-24 84.0 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain CheR PF01739.18 CCF36264.1 - 0.0068 15.9 0.0 0.012 15.1 0.0 1.3 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain Tropomyosin_1 PF12718.7 CCF36268.1 - 1.6e-53 180.7 31.0 1.9e-53 180.5 31.0 1.0 1 0 0 1 1 1 1 Tropomyosin like Tropomyosin PF00261.20 CCF36268.1 - 2.1e-08 33.9 30.7 0.00016 21.1 5.9 3.0 1 1 2 3 3 3 3 Tropomyosin CENP-F_leu_zip PF10473.9 CCF36268.1 - 0.00027 21.0 3.9 0.00027 21.0 3.9 2.8 1 1 1 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Spc7 PF08317.11 CCF36268.1 - 0.00037 19.5 30.8 0.013 14.4 13.3 2.0 1 1 1 2 2 2 2 Spc7 kinetochore protein DUF4200 PF13863.6 CCF36268.1 - 0.00054 20.3 31.8 0.074 13.5 14.5 2.4 2 1 0 2 2 2 2 Domain of unknown function (DUF4200) TACC_C PF05010.14 CCF36268.1 - 0.00061 19.6 22.6 0.0037 17.1 12.5 2.3 1 1 1 2 2 2 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal DUF724 PF05266.14 CCF36268.1 - 0.00081 19.3 22.1 0.014 15.2 7.2 2.0 2 0 0 2 2 2 2 Protein of unknown function (DUF724) Lebercilin PF15619.6 CCF36268.1 - 0.0012 18.5 30.0 0.14 11.8 15.8 2.1 1 1 1 2 2 2 2 Ciliary protein causing Leber congenital amaurosis disease ATG16 PF08614.11 CCF36268.1 - 0.0018 18.6 30.3 0.27 11.4 13.8 2.2 1 1 1 2 2 2 1 Autophagy protein 16 (ATG16) ADIP PF11559.8 CCF36268.1 - 0.0019 18.3 27.7 0.0085 16.2 7.0 3.1 1 1 2 3 3 3 1 Afadin- and alpha -actinin-Binding KLRAQ PF10205.9 CCF36268.1 - 0.0022 18.2 20.5 0.028 14.7 5.7 3.1 1 1 2 3 3 3 2 Predicted coiled-coil domain-containing protein HOOK PF05622.12 CCF36268.1 - 0.0025 16.1 24.9 0.0034 15.6 24.9 1.2 1 0 0 1 1 1 1 HOOK protein TMF_TATA_bd PF12325.8 CCF36268.1 - 0.003 17.8 23.0 0.015 15.5 13.2 2.4 1 1 1 2 2 2 1 TATA element modulatory factor 1 TATA binding Taxilin PF09728.9 CCF36268.1 - 0.003 16.8 28.7 0.13 11.5 7.5 2.1 1 1 1 2 2 2 2 Myosin-like coiled-coil protein GAS PF13851.6 CCF36268.1 - 0.0061 15.9 30.2 0.025 13.9 30.2 1.9 1 1 0 1 1 1 1 Growth-arrest specific micro-tubule binding Uso1_p115_C PF04871.13 CCF36268.1 - 0.0077 16.6 32.9 0.14 12.5 13.5 2.1 1 1 1 2 2 2 2 Uso1 / p115 like vesicle tethering protein, C terminal region APG6_N PF17675.1 CCF36268.1 - 0.013 16.1 36.7 0.21 12.1 21.9 2.2 1 1 1 2 2 2 0 Apg6 coiled-coil region CENP-K PF11802.8 CCF36268.1 - 0.015 14.9 17.4 0.066 12.8 2.2 2.1 1 1 1 2 2 2 0 Centromere-associated protein K Laminin_II PF06009.12 CCF36268.1 - 0.016 15.2 5.5 0.016 15.2 5.5 2.5 1 1 1 2 2 2 0 Laminin Domain II Fez1 PF06818.15 CCF36268.1 - 0.02 15.3 25.7 0.044 14.2 25.2 1.6 1 1 1 2 2 2 0 Fez1 ERM PF00769.19 CCF36268.1 - 0.027 14.3 33.8 0.047 13.5 15.6 2.1 1 1 1 2 2 2 0 Ezrin/radixin/moesin family TPR_MLP1_2 PF07926.12 CCF36268.1 - 0.031 14.3 33.4 0.21 11.6 9.3 2.5 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Surfac_D-trimer PF09006.11 CCF36268.1 - 0.037 13.9 3.2 0.047 13.6 0.0 2.7 4 0 0 4 4 2 0 Lung surfactant protein D coiled-coil trimerisation FlaC_arch PF05377.11 CCF36268.1 - 0.038 14.4 19.4 0.22 11.9 3.9 4.4 3 2 1 4 4 4 0 Flagella accessory protein C (FlaC) DUF1664 PF07889.12 CCF36268.1 - 0.038 14.0 14.2 0.11 12.5 3.4 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) KASH_CCD PF14662.6 CCF36268.1 - 0.041 13.7 28.2 0.026 14.3 26.0 2.0 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH DUF3450 PF11932.8 CCF36268.1 - 0.043 13.1 26.5 0.46 9.8 13.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) HMMR_N PF15905.5 CCF36268.1 - 0.056 12.9 27.0 0.076 12.5 27.0 1.2 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Fmp27_WPPW PF10359.9 CCF36268.1 - 0.063 12.1 22.7 0.015 14.2 8.9 2.0 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain bZIP_1 PF00170.21 CCF36268.1 - 0.078 13.1 29.6 0.43 10.7 3.5 4.9 2 1 4 6 6 5 0 bZIP transcription factor DUF2203 PF09969.9 CCF36268.1 - 0.08 13.7 16.5 0.54 11.0 3.7 2.2 1 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) NPV_P10 PF05531.12 CCF36268.1 - 0.094 13.2 9.0 13 6.3 0.1 3.2 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Serine_rich PF08824.10 CCF36268.1 - 0.1 12.6 9.3 0.16 11.9 7.5 2.0 1 1 1 2 2 2 0 Serine rich protein interaction domain EzrA PF06160.12 CCF36268.1 - 0.1 10.7 22.6 0.18 9.9 8.0 2.1 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA Rab5-bind PF09311.11 CCF36268.1 - 0.11 11.9 23.2 0.33 10.3 9.0 2.0 1 1 1 2 2 2 0 Rabaptin-like protein Jnk-SapK_ap_N PF09744.9 CCF36268.1 - 0.11 12.8 30.7 0.072 13.3 17.8 2.1 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 Syntaxin-6_N PF09177.11 CCF36268.1 - 0.12 12.9 17.3 0.95 10.1 6.9 2.8 1 1 1 2 2 2 0 Syntaxin 6, N-terminal UPF0242 PF06785.11 CCF36268.1 - 0.12 12.4 29.8 0.15 12.1 10.8 2.0 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus T3SSipB PF16535.5 CCF36268.1 - 0.13 12.7 19.2 1.7 9.1 8.2 2.8 1 1 1 2 2 2 0 Type III cell invasion protein SipB DUF4763 PF15960.5 CCF36268.1 - 0.14 11.4 16.7 0.23 10.7 3.9 2.5 1 1 2 3 3 3 0 Domain of unknown function (DUF4763) DUF5082 PF16888.5 CCF36268.1 - 0.28 11.5 20.9 2.4 8.4 4.7 3.1 1 1 2 3 3 3 0 Domain of unknown function (DUF5082) CALCOCO1 PF07888.11 CCF36268.1 - 0.29 10.0 28.9 1.8 7.3 9.8 2.0 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like CLZ PF16526.5 CCF36268.1 - 0.31 11.4 24.3 1.3 9.4 2.8 3.6 1 1 3 4 4 4 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels SOGA PF11365.8 CCF36268.1 - 0.31 12.2 22.9 3.5 8.8 9.5 3.6 1 1 2 3 3 3 0 Protein SOGA MAD PF05557.13 CCF36268.1 - 0.32 9.3 25.0 0.17 10.2 12.3 1.8 1 1 1 2 2 2 0 Mitotic checkpoint protein Cortex-I_coil PF09304.10 CCF36268.1 - 0.32 11.2 21.6 5.3 7.3 6.1 3.3 1 1 2 3 3 3 0 Cortexillin I, coiled coil Seryl_tRNA_N PF02403.22 CCF36268.1 - 0.34 11.2 25.1 0.34 11.2 0.3 3.1 1 1 1 2 2 1 0 Seryl-tRNA synthetase N-terminal domain KELK PF15796.5 CCF36268.1 - 0.36 11.3 30.5 0.39 11.2 3.3 3.8 1 1 3 4 4 4 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase HAP1_N PF04849.13 CCF36268.1 - 0.39 9.9 27.7 0.96 8.6 27.7 2.0 1 1 0 1 1 1 0 HAP1 N-terminal conserved region Filament PF00038.21 CCF36268.1 - 0.44 10.1 24.8 1.5 8.3 24.8 1.8 1 1 0 1 1 1 0 Intermediate filament protein HMMR_C PF15908.5 CCF36268.1 - 0.46 10.7 18.8 0.12 12.6 4.4 2.6 1 1 2 3 3 3 0 Hyaluronan mediated motility receptor C-terminal TANGO2 PF05742.12 CCF36268.1 - 0.5 10.4 7.3 0.88 9.6 7.1 1.6 1 1 0 1 1 1 0 Transport and Golgi organisation 2 CASP_C PF08172.12 CCF36268.1 - 0.5 9.7 21.2 0.084 12.2 2.5 2.1 1 1 1 2 2 2 0 CASP C terminal DUF3584 PF12128.8 CCF36268.1 - 0.62 7.5 24.6 0.86 7.0 24.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) LPP PF04728.13 CCF36268.1 - 0.69 10.3 11.0 31 5.1 0.1 4.2 3 1 0 3 3 3 0 Lipoprotein leucine-zipper Cep57_CLD_2 PF14197.6 CCF36268.1 - 0.76 9.9 25.4 3.7 7.7 0.2 4.2 2 2 1 3 3 3 0 Centrosome localisation domain of PPC89 DUF3287 PF11690.8 CCF36268.1 - 0.89 9.3 5.4 4.8 6.9 0.2 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF3287) VGPC1_C PF16799.5 CCF36268.1 - 1.1 9.4 8.4 0.53 10.3 3.8 2.7 2 1 0 2 2 2 0 C-terminal membrane-localisation domain of ion-channel, VCN1 WXG100 PF06013.12 CCF36268.1 - 1.1 9.5 16.1 3.3 8.0 0.2 4.1 3 1 1 4 4 4 0 Proteins of 100 residues with WXG BRE1 PF08647.11 CCF36268.1 - 1.4 9.0 30.1 13 5.9 8.9 3.0 1 1 2 3 3 3 0 BRE1 E3 ubiquitin ligase Alanine_zipper PF11839.8 CCF36268.1 - 1.5 9.3 13.1 1.3 9.4 2.8 3.6 1 1 3 4 4 4 0 Alanine-zipper, major outer membrane lipoprotein Cep57_MT_bd PF06657.13 CCF36268.1 - 1.7 9.1 18.7 0.69 10.4 2.5 3.4 1 1 1 3 3 3 0 Centrosome microtubule-binding domain of Cep57 DUF4407 PF14362.6 CCF36268.1 - 1.8 7.8 21.0 5 6.4 21.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DHR10 PF18595.1 CCF36268.1 - 1.9 8.6 33.4 16 5.6 23.4 3.1 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain CHDCT2 PF08074.11 CCF36268.1 - 1.9 8.6 10.1 0.22 11.7 4.2 1.9 1 1 1 2 2 2 0 CHDCT2 (NUC038) domain ZapB PF06005.12 CCF36268.1 - 1.9 9.0 36.9 8.3 6.9 1.2 4.1 1 1 2 3 3 3 0 Cell division protein ZapB DUF4686 PF15742.5 CCF36268.1 - 2.5 7.1 29.7 36 3.3 29.7 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4686) Syntaxin_2 PF14523.6 CCF36268.1 - 2.7 8.4 17.6 1.4 9.4 8.7 2.2 1 1 1 2 2 2 0 Syntaxin-like protein Sec34 PF04136.15 CCF36268.1 - 2.7 7.8 16.3 0.56 10.1 4.2 2.5 1 1 1 2 2 2 0 Sec34-like family Rootletin PF15035.6 CCF36268.1 - 2.8 7.9 27.3 34 4.4 27.4 2.0 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion Atg14 PF10186.9 CCF36268.1 - 2.9 6.9 20.5 2.8 6.9 11.2 2.1 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 AAA_13 PF13166.6 CCF36268.1 - 3 6.4 23.2 0.4 9.3 7.3 2.0 1 1 1 2 2 2 0 AAA domain DUF2937 PF11157.8 CCF36268.1 - 3.1 7.5 8.6 2.5 7.8 4.8 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2937) Fib_alpha PF08702.10 CCF36268.1 - 3.7 7.7 15.8 7.4 6.8 4.6 2.5 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Lectin_N PF03954.14 CCF36268.1 - 4 7.2 15.2 1.5 8.6 3.9 2.7 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain CENP-H PF05837.12 CCF36268.1 - 4.1 7.9 25.1 14 6.2 0.2 3.1 1 1 2 3 3 3 0 Centromere protein H (CENP-H) FUSC PF04632.12 CCF36268.1 - 4.2 5.8 6.4 4.9 5.6 6.4 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family OmpH PF03938.14 CCF36268.1 - 4.5 7.6 33.3 3.4 8.0 17.9 2.7 1 1 1 2 2 1 0 Outer membrane protein (OmpH-like) BST2 PF16716.5 CCF36268.1 - 4.8 7.8 26.1 6 7.5 9.3 3.5 1 1 1 3 3 3 0 Bone marrow stromal antigen 2 XhlA PF10779.9 CCF36268.1 - 4.8 7.5 23.0 4 7.7 2.2 4.1 2 1 1 4 4 4 0 Haemolysin XhlA DUF2730 PF10805.8 CCF36268.1 - 5.1 7.3 12.9 5.2 7.2 6.2 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) DUF4482 PF14818.6 CCF36268.1 - 5.1 8.0 21.5 0.34 11.8 2.4 3.0 1 1 0 2 2 2 0 Domain of unknown function (DUF4482) TMF_DNA_bd PF12329.8 CCF36268.1 - 5.2 7.1 33.4 54 3.9 10.4 3.2 1 1 2 3 3 3 0 TATA element modulatory factor 1 DNA binding DUF745 PF05335.13 CCF36268.1 - 5.3 6.7 19.2 0.25 11.1 5.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF745) CENP-Q PF13094.6 CCF36268.1 - 6.1 7.0 32.1 21 5.3 17.8 3.4 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit PI3K_P85_iSH2 PF16454.5 CCF36268.1 - 6.3 6.4 23.8 32 4.1 23.2 2.2 1 1 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Mod_r PF07200.13 CCF36268.1 - 6.4 6.9 25.4 3.2 7.9 16.1 2.1 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein TFR_dimer PF04253.15 CCF36268.1 - 6.6 6.9 15.2 0.53 10.4 2.1 3.1 1 1 2 3 3 3 0 Transferrin receptor-like dimerisation domain DUF4472 PF14739.6 CCF36268.1 - 6.7 7.5 24.7 5.1 7.9 2.2 2.8 1 1 2 3 3 3 0 Domain of unknown function (DUF4472) YabA PF06156.13 CCF36268.1 - 7 7.3 22.4 9.9 6.9 8.5 3.1 1 1 2 3 3 3 0 Initiation control protein YabA CorA PF01544.18 CCF36268.1 - 7.4 5.8 9.7 5.1 6.3 7.8 1.6 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein TRAF_BIRC3_bd PF16673.5 CCF36268.1 - 8.1 6.3 16.6 8.8 6.2 1.3 4.1 1 1 4 5 5 5 0 TNF receptor-associated factor BIRC3 binding domain Nop25 PF09805.9 CCF36269.1 - 3.8e-38 131.1 17.0 3.8e-38 131.1 17.0 2.3 2 0 0 2 2 2 1 Nucleolar protein 12 (25kDa) ATP-synt_S1 PF05827.12 CCF36270.1 - 0.00093 19.0 0.0 0.0017 18.2 0.0 1.4 1 0 0 1 1 1 1 Vacuolar ATP synthase subunit S1 (ATP6S1) Trm112p PF03966.16 CCF36271.1 - 2.6e-18 66.4 0.1 3.2e-18 66.0 0.1 1.1 1 0 0 1 1 1 1 Trm112p-like protein Zn_ribbon_recom PF13408.6 CCF36271.1 - 0.07 13.7 0.3 0.11 13.0 0.3 1.3 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain Glyco_hydro_3_C PF01915.22 CCF36272.1 - 5.6e-48 163.6 0.1 5.8e-47 160.3 0.1 2.2 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 CCF36272.1 - 5.6e-38 131.1 0.0 9.5e-38 130.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 CCF36272.1 - 1.4e-18 66.8 0.1 2.8e-18 65.8 0.1 1.6 1 0 0 1 1 1 1 Fibronectin type III-like domain Homeobox_KN PF05920.11 CCF36273.1 - 3.6e-22 78.0 0.6 8.3e-22 76.8 0.6 1.7 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 CCF36273.1 - 1e-08 34.9 1.4 2.6e-08 33.6 1.4 1.7 1 0 0 1 1 1 1 Homeodomain Ufd2P_core PF10408.9 CCF36274.1 - 9.9e-137 457.2 1.6 1.2e-136 456.9 1.6 1.1 1 0 0 1 1 1 1 Ubiquitin elongating factor core SOG2 PF10428.9 CCF36274.1 - 0.044 13.0 2.7 0.066 12.4 2.7 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein zf-TRAF PF02176.18 CCF36275.1 - 1.6e-08 35.1 21.1 4.8e-07 30.4 5.9 3.1 1 1 2 3 3 3 2 TRAF-type zinc finger zf-TRAF_2 PF15965.5 CCF36275.1 - 0.00077 19.9 9.1 0.00077 19.9 9.1 2.3 1 1 1 2 2 2 1 TRAF-like zinc-finger FlxA PF14282.6 CCF36275.1 - 0.0033 17.4 1.8 0.66 10.0 0.6 2.4 2 0 0 2 2 2 1 FlxA-like protein Laminin_II PF06009.12 CCF36275.1 - 0.019 15.0 3.3 0.88 9.6 0.1 3.2 3 1 1 4 4 4 0 Laminin Domain II zf_C2HC_14 PF18574.1 CCF36275.1 - 0.057 13.2 10.8 0.28 11.0 1.7 2.9 2 1 1 3 3 2 0 C2HC Zing finger domain BLOC1_2 PF10046.9 CCF36275.1 - 0.096 13.0 5.8 0.36 11.1 0.1 2.7 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF2408 PF10303.9 CCF36275.1 - 0.11 13.1 3.2 0.16 12.5 2.7 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) zf_UBZ PF18439.1 CCF36275.1 - 0.12 12.0 0.1 0.12 12.0 0.1 3.2 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger DivIC PF04977.15 CCF36275.1 - 0.13 12.1 6.2 0.38 10.5 3.8 2.4 2 0 0 2 2 2 0 Septum formation initiator Spc7 PF08317.11 CCF36275.1 - 0.19 10.6 11.1 0.63 8.9 2.3 2.3 3 0 0 3 3 3 0 Spc7 kinetochore protein Prefoldin_2 PF01920.20 CCF36275.1 - 0.32 11.0 11.0 1.2 9.1 3.8 2.7 2 1 0 2 2 2 0 Prefoldin subunit SlyX PF04102.12 CCF36275.1 - 0.35 11.5 8.6 0.25 12.0 0.8 3.1 2 1 0 2 2 2 0 SlyX SKA1 PF07160.12 CCF36275.1 - 0.49 10.2 10.9 2.5 7.9 2.0 3.0 2 1 1 3 3 3 0 Spindle and kinetochore-associated protein 1 TolA_bind_tri PF16331.5 CCF36275.1 - 0.52 10.4 7.0 1.5 9.0 0.6 2.6 2 1 0 2 2 2 0 TolA binding protein trimerisation TMF_DNA_bd PF12329.8 CCF36275.1 - 0.59 10.2 9.0 0.91 9.6 5.1 2.4 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF16 PF01519.16 CCF36275.1 - 0.6 10.6 9.8 0.41 11.2 7.0 2.1 1 1 1 2 2 2 0 Protein of unknown function DUF16 GAS PF13851.6 CCF36275.1 - 0.8 9.0 10.3 0.17 11.3 2.5 2.5 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding DUF848 PF05852.11 CCF36275.1 - 0.88 9.7 11.0 2.3 8.3 1.6 2.6 2 1 1 3 3 3 0 Gammaherpesvirus protein of unknown function (DUF848) PRP1_N PF06424.12 CCF36275.1 - 0.98 9.8 6.4 1.3 9.4 4.5 2.1 2 1 0 2 2 2 0 PRP1 splicing factor, N-terminal XhlA PF10779.9 CCF36275.1 - 3.5 7.9 6.9 13 6.0 0.3 2.4 2 0 0 2 2 2 0 Haemolysin XhlA Amidase PF01425.21 CCF36276.1 - 0.025 13.6 0.0 0.032 13.2 0.0 1.1 1 0 0 1 1 1 0 Amidase Acyltransferase PF01553.21 CCF36277.1 - 1.1e-09 38.0 0.0 0.00052 19.6 0.0 2.1 2 0 0 2 2 2 2 Acyltransferase MFS_1 PF07690.16 CCF36279.1 - 1.1e-09 37.8 8.9 1.3e-09 37.4 8.9 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF36279.1 - 2.2e-07 30.1 0.0 2.3e-07 30.0 0.0 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter Pam17 PF08566.10 CCF36279.1 - 0.047 13.5 0.0 0.064 13.1 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial import protein Pam17 TRI12 PF06609.13 CCF36279.1 - 0.051 12.0 0.2 0.06 11.7 0.2 1.0 1 0 0 1 1 1 0 Fungal trichothecene efflux pump (TRI12) MMgT PF10270.9 CCF36280.1 - 2.4e-35 120.9 0.0 2.9e-35 120.6 0.0 1.1 1 0 0 1 1 1 1 Membrane magnesium transporter HMG_box PF00505.19 CCF36281.1 - 8.2e-14 51.8 0.2 1.5e-12 47.7 0.1 2.3 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 CCF36281.1 - 0.00011 22.8 0.1 0.00025 21.6 0.1 1.7 1 0 0 1 1 1 1 HMG-box domain MATalpha_HMGbox PF04769.12 CCF36281.1 - 0.0038 16.6 0.0 0.0055 16.0 0.0 1.2 1 0 0 1 1 1 1 Mating-type protein MAT alpha 1 HMG-box ARHGEF5_35 PF15441.6 CCF36281.1 - 7.2 5.5 10.5 0.067 12.2 0.9 2.1 3 0 0 3 3 3 0 Rho guanine nucleotide exchange factor 5/35 Peptidase_M20 PF01546.28 CCF36282.1 - 2.3e-10 40.5 0.4 3.6e-10 39.9 0.4 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 CCF36282.1 - 9.6e-07 28.7 0.0 3.5e-06 26.9 0.0 2.0 1 1 0 1 1 1 1 Peptidase dimerisation domain DUF218 PF02698.17 CCF36283.1 - 5.2e-23 81.5 0.0 7.1e-23 81.1 0.0 1.1 1 0 0 1 1 1 1 DUF218 domain Glyco_hydro_3_C PF01915.22 CCF36284.1 - 5.6e-28 98.3 0.0 1.4e-20 74.1 0.0 2.5 1 1 1 2 2 2 2 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 CCF36284.1 - 2.6e-24 85.1 0.2 4.2e-24 84.4 0.2 1.3 1 0 0 1 1 1 1 Fibronectin type III-like domain Pectate_lyase PF03211.13 CCF36285.1 - 9.2e-56 188.6 1.9 1.2e-55 188.2 1.9 1.0 1 0 0 1 1 1 1 Pectate lyase IBR PF01485.21 CCF36286.1 - 3.8e-07 30.2 3.8 3.8e-07 30.2 3.8 3.3 3 1 0 3 3 3 2 IBR domain, a half RING-finger domain FYVE PF01363.21 CCF36287.1 - 0.0036 17.4 1.2 0.0058 16.7 1.2 1.4 1 0 0 1 1 1 1 FYVE zinc finger zf-AN1 PF01428.16 CCF36287.1 - 0.0069 16.5 5.1 0.014 15.6 5.1 1.5 1 0 0 1 1 1 1 AN1-like Zinc finger DUF702 PF05142.12 CCF36287.1 - 0.036 14.5 2.4 0.036 14.5 2.4 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF702) zf-UBP PF02148.19 CCF36287.1 - 0.055 13.8 1.1 0.09 13.1 1.1 1.4 1 0 0 1 1 1 0 Zn-finger in ubiquitin-hydrolases and other protein zf-HIT PF04438.16 CCF36287.1 - 0.056 13.3 4.8 0.1 12.5 4.8 1.4 1 0 0 1 1 1 0 HIT zinc finger zf-B_box PF00643.24 CCF36287.1 - 1.5 9.0 5.1 0.31 11.2 1.4 1.7 2 0 0 2 2 2 0 B-box zinc finger PIG-P PF08510.12 CCF36288.1 - 9.9e-51 170.7 0.8 1.3e-50 170.3 0.8 1.2 1 0 0 1 1 1 1 PIG-P DPM2 PF07297.12 CCF36288.1 - 0.02 15.2 9.0 0.038 14.3 9.0 1.4 1 0 0 1 1 1 0 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) DUF485 PF04341.12 CCF36288.1 - 4 7.5 7.2 0.43 10.6 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function, DUF485 Actin PF00022.19 CCF36289.1 - 3.3e-147 490.3 0.0 3.8e-147 490.2 0.0 1.0 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.13 CCF36289.1 - 1.1e-06 27.7 0.0 0.0024 16.7 0.0 2.3 2 0 0 2 2 2 2 MreB/Mbl protein DUF3591 PF12157.8 CCF36290.1 - 1.9e-175 583.8 2.6 2.7e-175 583.3 2.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3591) RGS PF00615.19 CCF36291.1 - 1.7e-38 131.5 0.4 9.7e-38 129.1 0.0 2.4 3 0 0 3 3 3 1 Regulator of G protein signaling domain DEP PF00610.21 CCF36291.1 - 5.1e-26 90.5 0.0 1.8e-21 75.9 0.0 3.5 3 0 0 3 3 3 2 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Replic_Relax PF13814.6 CCF36291.1 - 0.00053 20.1 0.0 0.21 11.6 0.0 2.4 2 0 0 2 2 2 2 Replication-relaxation NMT PF01233.19 CCF36291.1 - 0.13 12.1 0.0 0.26 11.1 0.0 1.5 1 0 0 1 1 1 0 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain Noelin-1 PF12308.8 CCF36291.1 - 0.17 11.9 0.4 7.4 6.6 0.0 2.5 2 0 0 2 2 2 0 Neurogenesis glycoprotein XhlA PF10779.9 CCF36293.1 - 0.014 15.5 0.1 0.04 14.1 0.1 1.8 1 0 0 1 1 1 0 Haemolysin XhlA PG_binding_1 PF01471.18 CCF36293.1 - 0.023 14.9 1.4 3.4 8.0 0.0 3.1 3 0 0 3 3 3 0 Putative peptidoglycan binding domain Spc7 PF08317.11 CCF36293.1 - 0.056 12.3 3.9 0.097 11.5 3.9 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF1664 PF07889.12 CCF36293.1 - 0.11 12.6 2.5 0.27 11.3 1.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) HMMR_N PF15905.5 CCF36293.1 - 0.2 11.1 5.4 0.32 10.4 5.4 1.2 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Laminin_II PF06009.12 CCF36293.1 - 0.22 11.5 3.6 3 7.9 0.5 2.8 1 1 2 3 3 3 0 Laminin Domain II Tropomyosin_1 PF12718.7 CCF36293.1 - 0.23 11.6 5.6 0.16 12.2 1.4 2.2 1 1 0 1 1 1 0 Tropomyosin like ATG16 PF08614.11 CCF36293.1 - 0.86 9.8 4.9 2.5 8.3 4.7 1.8 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) Peptidase_M35 PF02102.15 CCF36295.1 - 2e-07 30.2 0.1 2.3e-07 30.0 0.1 1.2 1 0 0 1 1 1 1 Deuterolysin metalloprotease (M35) family DUF3869 PF12985.7 CCF36295.1 - 0.19 12.1 3.2 0.2 12.0 2.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3869) DUF2014 PF09427.10 CCF36296.1 - 4.3e-113 377.0 7.0 7.5e-113 376.2 7.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF2014) HLH PF00010.26 CCF36296.1 - 4.1e-17 61.9 1.8 1.5e-16 60.1 0.9 2.2 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain SUIM_assoc PF16619.5 CCF36296.1 - 0.57 10.3 6.5 0.28 11.3 3.7 1.9 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 A_deaminase PF00962.22 CCF36298.1 - 2.2e-22 79.9 0.0 2.6e-22 79.6 0.0 1.1 1 0 0 1 1 1 1 Adenosine/AMP deaminase Amidohydro_3 PF07969.11 CCF36298.1 - 0.025 14.0 0.1 0.046 13.2 0.1 1.3 1 1 0 1 1 1 0 Amidohydrolase family MFS_1 PF07690.16 CCF36299.1 - 9.8e-32 110.2 12.3 9.8e-32 110.2 12.3 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_4 PF06779.14 CCF36299.1 - 0.00057 19.3 0.4 0.0012 18.2 0.4 1.5 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB EamA PF00892.20 CCF36299.1 - 0.066 13.4 0.3 0.066 13.4 0.3 3.5 4 1 0 4 4 4 0 EamA-like transporter family TauD PF02668.16 CCF36300.1 - 1.9e-59 201.7 0.4 2.4e-59 201.3 0.4 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Pkinase PF00069.25 CCF36301.1 - 1.6e-12 47.4 0.0 2.4e-12 46.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF36301.1 - 4.1e-07 29.5 0.0 5.7e-07 29.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CCF36301.1 - 3.7e-05 23.8 0.9 8e-05 22.7 0.2 1.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 CCF36301.1 - 0.00061 19.2 0.0 0.00095 18.6 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 CCF36301.1 - 0.00083 19.0 0.0 0.0021 17.7 0.0 1.7 2 0 0 2 2 2 1 Choline/ethanolamine kinase RIO1 PF01163.22 CCF36301.1 - 0.0019 17.8 0.0 0.0038 16.9 0.0 1.4 1 0 0 1 1 1 1 RIO1 family Baculo_VP39 PF04501.12 CCF36301.1 - 0.05 13.1 0.0 0.076 12.5 0.0 1.4 1 1 0 1 1 1 0 Baculovirus major capsid protein VP39 SET PF00856.28 CCF36302.1 - 3e-19 70.0 0.0 1.6e-18 67.7 0.0 2.0 1 1 0 1 1 1 1 SET domain Pre-SET PF05033.16 CCF36302.1 - 9.4e-19 68.1 8.2 2.2e-18 66.9 5.1 2.3 2 0 0 2 2 2 1 Pre-SET motif Fungal_trans PF04082.18 CCF36303.1 - 1.7e-17 63.3 0.6 4.3e-17 62.0 0.6 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF36303.1 - 3.2e-05 23.9 9.8 5.6e-05 23.2 9.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fcf1 PF04900.12 CCF36304.1 - 2.3e-33 114.5 0.9 7.3e-33 112.9 0.2 2.0 3 0 0 3 3 3 1 Fcf1 PIN_9 PF18477.1 CCF36304.1 - 6.1e-09 36.2 0.0 5e-08 33.3 0.0 2.0 2 0 0 2 2 2 1 PIN like domain GCV_T PF01571.21 CCF36304.1 - 0.035 13.5 0.0 0.055 12.8 0.0 1.2 1 0 0 1 1 1 0 Aminomethyltransferase folate-binding domain TIP49 PF06068.13 CCF36305.1 - 7.1e-168 558.3 0.2 8.5e-168 558.0 0.2 1.0 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 CCF36305.1 - 5.6e-14 52.0 0.0 1.4e-13 50.7 0.0 1.7 1 0 0 1 1 1 1 TIP49 AAA-lid domain AAA PF00004.29 CCF36305.1 - 1.7e-11 44.7 0.2 6.6e-07 29.8 0.1 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 CCF36305.1 - 4.9e-09 36.1 0.1 1.7e-06 27.8 0.0 2.5 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 CCF36305.1 - 0.00024 21.4 0.2 0.28 11.5 0.0 2.5 2 1 0 2 2 2 2 AAA domain AAA_19 PF13245.6 CCF36305.1 - 0.00042 20.7 2.3 0.042 14.2 0.4 2.4 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 CCF36305.1 - 0.00068 20.1 0.1 0.0056 17.1 0.1 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA_28 PF13521.6 CCF36305.1 - 0.0031 17.8 0.1 0.0055 17.0 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CCF36305.1 - 0.0054 17.3 0.0 0.013 16.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 CCF36305.1 - 0.006 16.6 0.1 0.18 11.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 CCF36305.1 - 0.014 15.1 0.1 0.88 9.3 0.1 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_25 PF13481.6 CCF36305.1 - 0.017 14.7 0.1 0.12 11.9 0.1 2.1 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 CCF36305.1 - 0.018 14.3 0.2 0.051 12.9 0.1 1.7 2 0 0 2 2 2 0 Zeta toxin Mg_chelatase PF01078.21 CCF36305.1 - 0.026 13.9 0.1 0.75 9.1 0.1 2.2 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI DUF2075 PF09848.9 CCF36305.1 - 0.033 13.5 0.2 0.07 12.4 0.0 1.6 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) DnaB_C PF03796.15 CCF36305.1 - 0.04 13.2 0.0 0.09 12.1 0.0 1.5 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain AAA_7 PF12775.7 CCF36305.1 - 0.063 12.8 0.1 0.19 11.3 0.0 1.7 2 0 0 2 2 2 0 P-loop containing dynein motor region IstB_IS21 PF01695.17 CCF36305.1 - 0.084 12.6 0.2 0.2 11.4 0.2 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein ResIII PF04851.15 CCF36305.1 - 0.092 12.7 0.1 5 7.1 0.0 2.4 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit EamA PF00892.20 CCF36306.1 - 3.4e-21 75.8 23.8 2e-10 41.0 2.6 2.1 2 0 0 2 2 2 2 EamA-like transporter family Aa_trans PF01490.18 CCF36307.1 - 4.7e-29 101.3 30.6 6.4e-29 100.9 30.6 1.2 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein p450 PF00067.22 CCF36308.1 - 4.4e-73 246.6 0.0 5.4e-73 246.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 ScsC_N PF18312.1 CCF36308.1 - 0.16 11.8 0.2 0.36 10.7 0.2 1.5 1 0 0 1 1 1 0 Copper resistance protein ScsC N-terminal domain XLF PF09302.11 CCF36311.1 - 2.3e-57 194.1 0.3 4e-57 193.3 0.3 1.4 1 0 0 1 1 1 1 XLF-Cernunnos, XRcc4-like factor, NHEJ component TFIIE_alpha PF02002.17 CCF36311.1 - 0.15 11.9 0.0 0.91 9.4 0.0 2.1 2 0 0 2 2 2 0 TFIIE alpha subunit HATPase_c PF02518.26 CCF36313.1 - 1.1e-22 80.6 0.1 2.2e-22 79.7 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CCF36313.1 - 6.9e-21 74.5 0.0 1.7e-20 73.2 0.0 1.7 1 0 0 1 1 1 1 Response regulator receiver domain PAS_4 PF08448.10 CCF36313.1 - 1e-08 35.4 0.0 0.0038 17.5 0.0 2.9 3 0 0 3 3 3 2 PAS fold PAS_9 PF13426.7 CCF36313.1 - 7.3e-08 32.6 0.0 8.1e-07 29.2 0.0 2.7 2 1 1 3 3 3 1 PAS domain HisKA PF00512.25 CCF36313.1 - 5.4e-07 29.6 0.2 5.4e-07 29.6 0.2 1.9 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain GAF_2 PF13185.6 CCF36313.1 - 2.3e-05 24.7 0.0 0.026 14.8 0.0 2.6 2 0 0 2 2 2 2 GAF domain PAS_3 PF08447.12 CCF36313.1 - 0.00016 21.9 0.0 0.00054 20.2 0.0 1.9 1 0 0 1 1 1 1 PAS fold PAS PF00989.25 CCF36313.1 - 0.0015 18.5 0.0 0.0067 16.4 0.0 2.2 2 0 0 2 2 2 1 PAS fold PAS_8 PF13188.7 CCF36313.1 - 0.0027 17.7 0.0 0.011 15.7 0.0 2.1 2 0 0 2 2 2 1 PAS domain GAF_3 PF13492.6 CCF36313.1 - 0.022 15.1 0.0 0.065 13.6 0.0 1.8 1 0 0 1 1 1 0 GAF domain Aldo_ket_red PF00248.21 CCF36317.1 - 5.5e-54 183.3 0.0 6.3e-54 183.2 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Shal-type PF11601.8 CCF36317.1 - 0.073 12.6 0.2 0.15 11.6 0.2 1.5 1 0 0 1 1 1 0 Shal-type voltage-gated potassium channels, N-terminal Epimerase PF01370.21 CCF36318.1 - 1.2e-21 77.3 0.0 1.4e-21 77.1 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CCF36318.1 - 2.1e-15 56.5 0.0 2.8e-15 56.1 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 CCF36318.1 - 7e-11 42.1 0.0 1.1e-10 41.5 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 CCF36318.1 - 9e-08 31.6 0.0 1.4e-07 31.0 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 CCF36318.1 - 9.2e-08 31.6 0.1 0.0037 16.5 0.0 2.5 2 1 0 2 2 2 2 Male sterility protein NAD_binding_10 PF13460.6 CCF36318.1 - 8.2e-05 22.6 0.0 0.00012 22.0 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding adh_short PF00106.25 CCF36318.1 - 0.00015 21.2 0.0 0.0044 16.5 0.0 2.6 2 1 0 2 2 2 1 short chain dehydrogenase NmrA PF05368.13 CCF36318.1 - 0.00048 19.8 0.1 0.019 14.5 0.0 2.1 2 0 0 2 2 2 1 NmrA-like family KR PF08659.10 CCF36318.1 - 0.0023 17.9 0.0 0.0057 16.6 0.0 1.7 1 0 0 1 1 1 1 KR domain Ldh_1_N PF00056.23 CCF36318.1 - 0.025 14.7 0.0 0.049 13.7 0.0 1.5 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 CCF36318.1 - 0.029 14.6 0.0 0.051 13.8 0.0 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Polysacc_synt_2 PF02719.15 CCF36318.1 - 0.065 12.4 0.0 0.2 10.7 0.0 1.7 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein FMN_dh PF01070.18 CCF36319.1 - 1.1e-116 389.7 0.0 1.4e-116 389.4 0.0 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 CCF36319.1 - 3e-19 68.9 0.0 5.9e-19 68.0 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.17 CCF36319.1 - 0.00027 20.2 0.0 0.00059 19.1 0.0 1.5 1 0 0 1 1 1 1 Conserved region in glutamate synthase ThiG PF05690.14 CCF36319.1 - 0.00035 20.0 0.1 0.017 14.4 0.0 2.4 1 1 1 2 2 2 1 Thiazole biosynthesis protein ThiG IMPDH PF00478.25 CCF36319.1 - 0.0015 17.6 0.2 0.0051 15.9 0.2 1.8 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.15 CCF36319.1 - 0.0026 17.2 0.0 0.0044 16.4 0.0 1.3 1 0 0 1 1 1 1 Nitronate monooxygenase TMP-TENI PF02581.17 CCF36319.1 - 0.14 11.5 0.0 0.43 9.9 0.0 1.8 2 0 0 2 2 2 0 Thiamine monophosphate synthase DHDPS PF00701.22 CCF36320.1 - 5.3e-17 61.5 0.0 6e-17 61.3 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family GGDEF_2 PF17853.1 CCF36320.1 - 0.038 14.3 0.0 0.044 14.0 0.0 1.1 1 0 0 1 1 1 0 GGDEF-like domain MRP_L53 PF10780.9 CCF36321.1 - 1.8e-21 76.0 0.6 2.2e-21 75.7 0.6 1.1 1 0 0 1 1 1 1 39S ribosomal protein L53/MRP-L53 Sec20 PF03908.13 CCF36322.1 - 3.1e-14 52.6 0.7 9.8e-14 51.1 0.1 2.1 2 0 0 2 2 2 1 Sec20 G5 PF07501.12 CCF36322.1 - 0.1 13.0 1.2 0.23 11.9 0.1 2.2 2 0 0 2 2 2 0 G5 domain Flg_hook PF02120.16 CCF36322.1 - 0.31 11.0 5.2 2.2 8.2 0.1 3.2 3 0 0 3 3 3 0 Flagellar hook-length control protein FliK ZapB PF06005.12 CCF36322.1 - 0.54 10.7 5.9 34 5.0 5.9 2.8 1 1 0 1 1 1 0 Cell division protein ZapB Hemerythrin PF01814.23 CCF36322.1 - 2.6 8.7 5.9 64 4.2 0.0 3.0 2 1 0 2 2 2 0 Hemerythrin HHE cation binding domain Peptidase_S8 PF00082.22 CCF36324.1 - 5.1e-38 131.0 0.0 2.3e-37 128.9 0.0 2.0 1 1 0 1 1 1 1 Subtilase family fn3_5 PF06280.12 CCF36324.1 - 1.3e-11 45.2 0.4 4.6e-11 43.4 0.1 2.1 2 0 0 2 2 2 1 Fn3-like domain FlgD_ig PF13860.6 CCF36324.1 - 0.12 12.3 0.7 0.41 10.5 0.1 2.3 2 0 0 2 2 2 0 FlgD Ig-like domain MFS_1 PF07690.16 CCF36326.1 - 2.9e-12 46.2 20.6 3.3e-12 46.0 20.6 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.6 CCF36326.1 - 3.8 6.0 15.1 16 3.9 15.4 1.8 1 1 0 1 1 1 0 MFS/sugar transport protein Trp_halogenase PF04820.14 CCF36327.1 - 9.8e-28 97.2 0.0 9.8e-15 54.3 0.0 2.2 1 1 1 2 2 2 2 Tryptophan halogenase FAD_binding_3 PF01494.19 CCF36327.1 - 2.4e-12 46.8 0.0 6.2e-12 45.4 0.0 1.7 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 CCF36327.1 - 1.8e-05 24.8 0.1 7.5e-05 22.9 0.2 2.1 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CCF36327.1 - 2.2e-05 23.8 0.2 8.6e-05 21.9 0.2 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 CCF36327.1 - 0.00022 20.7 0.2 0.00044 19.7 0.2 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CCF36327.1 - 0.00035 19.8 0.1 0.0006 19.0 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain GIDA PF01134.22 CCF36327.1 - 0.0014 17.8 0.1 0.0024 17.0 0.1 1.4 1 0 0 1 1 1 1 Glucose inhibited division protein A HI0933_like PF03486.14 CCF36327.1 - 0.0017 17.2 0.1 0.0025 16.6 0.1 1.2 1 0 0 1 1 1 1 HI0933-like protein DAO PF01266.24 CCF36327.1 - 0.015 14.9 0.8 0.035 13.7 0.3 1.8 2 0 0 2 2 2 0 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 CCF36327.1 - 0.017 14.4 0.0 0.028 13.7 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCF36327.1 - 0.095 13.3 0.1 0.25 11.9 0.1 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Peptidase_S9 PF00326.21 CCF36328.1 - 0.0065 16.0 0.0 0.009 15.5 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 CCF36328.1 - 0.061 12.6 0.0 0.087 12.1 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 CCF36328.1 - 0.13 12.1 0.0 0.23 11.3 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF2205 PF10224.9 CCF36329.1 - 3.5e-35 119.8 0.3 6.9e-35 118.9 0.3 1.5 1 0 0 1 1 1 1 Short coiled-coil protein AAA_32 PF13654.6 CCF36329.1 - 0.033 13.0 0.1 0.04 12.7 0.1 1.1 1 0 0 1 1 1 0 AAA domain Nramp PF01566.18 CCF36331.1 - 2e-79 267.2 13.5 4.7e-79 266.0 13.5 1.5 1 1 0 1 1 1 1 Natural resistance-associated macrophage protein SMK-1 PF04802.15 CCF36332.1 - 2.2e-84 282.1 0.6 4.3e-84 281.1 0.6 1.5 1 0 0 1 1 1 1 Component of IIS longevity pathway SMK-1 DUF5630 PF18632.1 CCF36332.1 - 0.08 12.3 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5630) TPR_7 PF13176.6 CCF36333.1 - 0.006 16.5 0.9 7.1 6.9 0.0 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat Poxvirus PF06227.12 CCF36333.1 - 0.13 12.0 0.1 0.23 11.2 0.1 1.4 1 0 0 1 1 1 0 dsDNA Poxvirus Zn_clus PF00172.18 CCF36335.1 - 2e-07 31.0 11.8 3.8e-07 30.1 11.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2013 PF09431.10 CCF36336.1 - 8e-52 175.1 1.3 8e-52 175.1 1.3 1.8 2 1 0 2 2 2 1 Protein of unknown function (DUF2013) Kinesin PF00225.23 CCF36340.1 - 1.1e-113 379.6 0.0 1.8e-113 378.8 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 CCF36340.1 - 3.8e-26 91.8 0.0 9.3e-26 90.5 0.0 1.6 1 0 0 1 1 1 1 Microtubule binding DUF1087 PF06465.13 CCF36340.1 - 0.0066 16.5 0.1 0.022 14.8 0.1 1.9 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1087) IL11 PF07400.11 CCF36340.1 - 0.067 12.8 0.1 0.16 11.6 0.1 1.6 1 0 0 1 1 1 0 Interleukin 11 YabA PF06156.13 CCF36340.1 - 0.38 11.4 8.5 5.3 7.8 0.0 3.5 3 1 0 3 3 3 0 Initiation control protein YabA DUF87 PF01935.17 CCF36340.1 - 0.72 9.9 0.0 0.72 9.9 0.0 3.0 3 1 0 3 3 3 0 Helicase HerA, central domain DUF5094 PF17015.5 CCF36340.1 - 6 6.9 7.7 2.8 8.0 4.9 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5094) PUL PF08324.11 CCF36341.1 - 1.8e-60 204.6 0.0 2.7e-60 204.0 0.0 1.2 1 0 0 1 1 1 1 PUL domain Peptidase_C97 PF05903.14 CCF36341.1 - 2.9e-35 121.3 0.0 4.6e-35 120.7 0.0 1.3 1 0 0 1 1 1 1 PPPDE putative peptidase domain Thioredoxin PF00085.20 CCF36341.1 - 2.8e-11 43.3 0.0 5.9e-11 42.3 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin TraF PF13728.6 CCF36341.1 - 0.00014 21.7 0.0 0.00024 21.0 0.0 1.3 1 0 0 1 1 1 1 F plasmid transfer operon protein Thioredoxin_9 PF14595.6 CCF36341.1 - 0.016 15.0 0.0 0.029 14.1 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin Redoxin PF08534.10 CCF36341.1 - 0.07 12.8 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 Redoxin Thioredoxin_2 PF13098.6 CCF36341.1 - 0.1 13.0 0.1 0.36 11.3 0.1 2.0 1 1 0 1 1 1 0 Thioredoxin-like domain Glutaredoxin PF00462.24 CCF36341.1 - 0.1 12.8 0.0 0.36 11.1 0.0 1.9 1 0 0 1 1 1 0 Glutaredoxin DUF4524 PF15025.6 CCF36341.1 - 0.14 11.9 0.3 0.9 9.3 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4524) GDA1_CD39 PF01150.17 CCF36342.1 - 1e-102 344.0 0.0 1.3e-102 343.6 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Ppx-GppA PF02541.16 CCF36342.1 - 0.042 13.3 0.0 0.072 12.5 0.0 1.3 1 0 0 1 1 1 0 Ppx/GppA phosphatase family AAA_lid_2 PF17863.1 CCF36343.1 - 2.6e-06 27.2 0.4 6.5e-06 25.9 0.4 1.7 1 0 0 1 1 1 1 AAA lid domain Ras PF00071.22 CCF36344.1 - 3.9e-57 192.4 0.1 4.6e-57 192.1 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCF36344.1 - 4.6e-32 110.7 0.0 6.6e-32 110.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCF36344.1 - 3.2e-13 49.5 0.0 3.8e-13 49.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 CCF36344.1 - 5e-08 33.0 0.0 8.2e-08 32.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 CCF36344.1 - 2.8e-06 26.9 0.0 3.4e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 CCF36344.1 - 4.2e-05 23.2 0.0 0.0018 17.9 0.0 2.2 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 CCF36344.1 - 9.3e-05 22.4 0.1 0.0037 17.2 0.1 2.4 1 1 2 3 3 3 1 RsgA GTPase SRPRB PF09439.10 CCF36344.1 - 0.0024 17.3 0.0 0.003 17.0 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_5 PF07728.14 CCF36344.1 - 0.0038 17.2 0.0 0.0066 16.4 0.0 1.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) PduV-EutP PF10662.9 CCF36344.1 - 0.0058 16.4 0.1 0.13 12.0 0.0 2.2 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.6 CCF36344.1 - 0.0085 16.5 0.0 0.014 15.8 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 CCF36344.1 - 0.0095 16.2 0.0 0.016 15.5 0.0 1.5 1 1 0 1 1 1 1 AAA domain ATP_bind_1 PF03029.17 CCF36344.1 - 0.012 15.5 0.2 0.33 10.7 0.0 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein AAA_24 PF13479.6 CCF36344.1 - 0.02 14.7 0.0 0.042 13.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain Septin PF00735.18 CCF36344.1 - 0.02 14.2 0.1 0.048 12.9 0.0 1.7 2 0 0 2 2 2 0 Septin NB-ARC PF00931.22 CCF36344.1 - 0.021 14.0 0.1 0.29 10.3 0.0 2.0 2 0 0 2 2 2 0 NB-ARC domain AAA_7 PF12775.7 CCF36344.1 - 0.024 14.1 0.1 0.041 13.4 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region cobW PF02492.19 CCF36344.1 - 0.038 13.6 0.0 0.1 12.2 0.0 1.7 1 1 1 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ATPase_2 PF01637.18 CCF36344.1 - 0.059 13.3 0.2 0.13 12.1 0.0 1.6 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea NTPase_1 PF03266.15 CCF36344.1 - 0.096 12.6 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 NTPase TniB PF05621.11 CCF36344.1 - 0.12 11.8 0.0 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein NACHT PF05729.12 CCF36344.1 - 0.12 12.2 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 NACHT domain RNA_helicase PF00910.22 CCF36344.1 - 0.14 12.5 0.0 0.52 10.7 0.0 1.9 2 0 0 2 2 2 0 RNA helicase EamA PF00892.20 CCF36345.1 - 9.4e-10 38.8 36.0 6.6e-06 26.3 5.5 3.1 3 0 0 3 3 3 3 EamA-like transporter family DUF3955 PF13127.6 CCF36345.1 - 5.4e-09 35.7 1.2 5.4e-09 35.7 1.2 3.0 3 0 0 3 3 3 1 Protein of unknown function (DUF3955) PUNUT PF16913.5 CCF36345.1 - 4.9e-08 32.6 1.5 4.9e-08 32.6 1.5 2.1 3 0 0 3 3 3 1 Purine nucleobase transmembrane transport SLC35F PF06027.12 CCF36345.1 - 0.00013 21.6 13.4 0.00013 21.6 13.4 2.0 2 0 0 2 2 2 1 Solute carrier family 35 UAA PF08449.11 CCF36345.1 - 0.0022 17.3 13.9 0.0022 17.3 13.9 1.5 2 0 0 2 2 2 1 UAA transporter family Brr6_like_C_C PF10104.9 CCF36345.1 - 5.1 6.9 7.9 2.5 7.9 0.1 3.0 3 0 0 3 3 3 0 Di-sulfide bridge nucleocytoplasmic transport domain Choline_transpo PF04515.12 CCF36346.1 - 3.7e-27 95.4 22.0 3.7e-27 95.4 22.0 2.3 2 1 0 2 2 2 1 Plasma-membrane choline transporter GST_N PF02798.20 CCF36347.1 - 3e-14 53.1 0.0 5.2e-14 52.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 CCF36347.1 - 2.4e-13 50.3 0.0 4.7e-13 49.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CCF36347.1 - 1.5e-10 41.3 0.0 3.4e-10 40.1 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CCF36347.1 - 1.6e-09 37.9 0.1 3.7e-09 36.7 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 CCF36347.1 - 2.6e-08 34.0 0.0 4.8e-08 33.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CCF36347.1 - 1.2e-07 31.6 0.2 2.5e-07 30.6 0.2 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain MetRS-N PF09635.10 CCF36347.1 - 0.18 12.3 0.0 0.37 11.3 0.0 1.7 1 1 0 1 1 1 0 MetRS-N binding domain SF1-HH PF16275.5 CCF36348.1 - 3.5e-34 117.5 1.3 3.5e-34 117.5 1.3 2.6 1 1 1 2 2 2 1 Splicing factor 1 helix-hairpin domain Glyco_hydro_3 PF00933.21 CCF36349.1 - 9.7e-37 127.0 0.0 1.8e-36 126.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.22 CCF36349.1 - 1.6e-30 106.6 0.0 2.3e-30 106.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Ser_hydrolase PF06821.13 CCF36349.1 - 0.14 12.0 0.0 0.37 10.6 0.0 1.7 1 0 0 1 1 1 0 Serine hydrolase Lipase_GDSL_2 PF13472.6 CCF36350.1 - 2.1e-17 64.1 0.5 2.5e-17 63.8 0.5 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 CCF36350.1 - 8.7e-12 45.4 0.1 1e-11 45.2 0.1 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_3 PF14606.6 CCF36350.1 - 0.00024 21.3 0.0 0.00038 20.6 0.0 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Tryp_inh PF17983.1 CCF36351.1 - 0.038 14.1 9.5 0.038 14.1 9.5 1.6 2 0 0 2 2 2 0 Trypsin inhibitors 1,2 and 3 Toxin_35 PF10530.9 CCF36351.1 - 0.081 12.9 3.4 0.091 12.8 3.4 1.1 1 0 0 1 1 1 0 Toxin with inhibitor cystine knot ICK or Knottin scaffold Cupin_2 PF07883.11 CCF36353.1 - 2.2e-21 75.3 1.3 2.1e-18 65.8 0.2 2.4 2 0 0 2 2 2 2 Cupin domain AraC_binding PF02311.19 CCF36353.1 - 0.00056 19.8 0.3 0.0012 18.7 0.3 1.6 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_3 PF05899.12 CCF36353.1 - 0.0021 17.7 0.0 0.045 13.5 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF861) Cupin_1 PF00190.22 CCF36353.1 - 0.0083 15.7 0.0 0.071 12.7 0.0 2.1 2 0 0 2 2 2 1 Cupin FAA_hydrolase PF01557.18 CCF36354.1 - 7.7e-33 114.0 0.0 1e-32 113.6 0.0 1.2 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family CENP-F_leu_zip PF10473.9 CCF36356.1 - 0.17 11.9 1.0 0.33 11.0 1.0 1.4 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 LTXXQ PF07813.12 CCF36356.1 - 3 8.6 8.3 0.32 11.7 0.7 2.7 2 0 0 2 2 2 0 LTXXQ motif family protein BSP PF04450.12 CCF36359.1 - 1.3e-77 260.3 0.0 1.5e-77 260.1 0.0 1.0 1 0 0 1 1 1 1 Peptidase of plants and bacteria SprT-like PF10263.9 CCF36359.1 - 0.065 13.1 0.1 0.097 12.5 0.1 1.3 1 0 0 1 1 1 0 SprT-like family CLASP_N PF12348.8 CCF36360.1 - 1.1e-138 460.2 0.0 6.4e-90 300.7 0.0 2.1 2 0 0 2 2 2 2 CLASP N terminal HEAT PF02985.22 CCF36360.1 - 9e-05 22.4 0.0 6.1 7.4 0.0 4.7 4 0 0 4 4 4 2 HEAT repeat HEAT_2 PF13646.6 CCF36360.1 - 0.025 15.0 0.1 22 5.5 0.0 4.1 3 1 1 4 4 4 0 HEAT repeats Cnd1 PF12717.7 CCF36360.1 - 0.039 14.0 0.0 3.4 7.7 0.0 2.9 2 2 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 CCF36360.1 - 0.18 10.3 0.0 3.9 5.9 0.0 2.6 2 0 0 2 2 2 0 Adaptin N terminal region DUF3328 PF11807.8 CCF36363.1 - 3.9e-11 43.2 0.5 6.2e-11 42.5 0.5 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF3328) ketoacyl-synt PF00109.26 CCF36364.1 - 5.5e-40 137.5 1.3 2.7e-38 132.0 1.3 2.5 1 1 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 CCF36364.1 - 0.04 13.8 1.0 0.11 12.4 1.0 1.8 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III FAE1_CUT1_RppA PF08392.12 CCF36364.1 - 0.047 13.0 1.3 0.072 12.4 1.3 1.2 1 0 0 1 1 1 0 FAE1/Type III polyketide synthase-like protein Thiolase_N PF00108.23 CCF36364.1 - 0.059 12.7 0.1 0.097 12.0 0.1 1.3 1 0 0 1 1 1 0 Thiolase, N-terminal domain Cu-oxidase_3 PF07732.15 CCF36366.1 - 5.3e-37 126.4 0.7 2.5e-36 124.3 0.6 2.2 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 CCF36366.1 - 4.7e-23 81.4 6.7 8.1e-18 64.5 0.2 3.9 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 CCF36366.1 - 4.5e-17 62.6 0.1 1.2e-16 61.2 0.0 1.8 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase PF00394.22 CCF36367.1 - 1.4e-16 61.0 0.0 2.4e-16 60.3 0.0 1.3 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 CCF36367.1 - 7.1e-10 38.8 0.0 0.00014 21.6 0.0 2.3 2 0 0 2 2 2 2 Multicopper oxidase PhyH PF05721.13 CCF36368.1 - 1.2e-13 51.8 0.0 6.6e-13 49.4 0.0 1.9 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Herpes_UL79 PF03049.14 CCF36370.1 - 0.13 11.9 0.0 0.23 11.1 0.0 1.4 1 0 0 1 1 1 0 UL79 family Zn_clus PF00172.18 CCF36370.1 - 2.1 8.5 8.1 5.6 7.2 8.1 1.7 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain DAO PF01266.24 CCF36371.1 - 1.1e-33 117.2 0.2 1.7e-33 116.6 0.2 1.3 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 CCF36371.1 - 8.3e-07 29.1 0.3 0.014 15.4 0.0 2.3 2 0 0 2 2 2 2 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 CCF36371.1 - 0.0005 19.4 0.4 0.74 9.0 0.2 2.3 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 CCF36371.1 - 0.0016 17.4 0.2 0.36 9.6 0.1 2.2 2 0 0 2 2 2 2 Tryptophan halogenase GIDA PF01134.22 CCF36371.1 - 0.0029 16.8 0.2 0.008 15.3 0.0 1.7 2 0 0 2 2 2 1 Glucose inhibited division protein A Lycopene_cycl PF05834.12 CCF36371.1 - 0.004 16.3 0.2 1.1 8.2 0.0 2.1 2 0 0 2 2 2 2 Lycopene cyclase protein NAD_binding_8 PF13450.6 CCF36371.1 - 0.0053 16.9 0.4 0.014 15.6 0.1 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 CCF36371.1 - 0.026 13.8 0.1 3 7.0 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 CCF36371.1 - 0.026 14.9 0.0 0.045 14.2 0.0 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding Amino_oxidase PF01593.24 CCF36371.1 - 0.069 12.4 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase Transp_cyt_pur PF02133.15 CCF36372.1 - 3.6e-79 266.6 41.2 4.1e-79 266.4 41.2 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Pmp3 PF01679.17 CCF36373.1 - 9.6e-20 70.5 7.6 1.3e-19 70.2 7.6 1.2 1 0 0 1 1 1 1 Proteolipid membrane potential modulator LPMO_10 PF03067.15 CCF36375.1 - 4.4e-09 37.3 0.1 6.7e-09 36.7 0.1 1.3 1 0 0 1 1 1 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading CFEM PF05730.11 CCF36376.1 - 2.7e-13 49.8 7.9 4.5e-13 49.1 7.9 1.4 1 0 0 1 1 1 1 CFEM domain CPCFC PF17223.3 CCF36377.1 - 0.22 11.3 4.2 0.45 10.3 4.2 1.5 1 0 0 1 1 1 0 Cuticle protein CPCFC Fungal_trans PF04082.18 CCF36379.1 - 4.7e-22 78.3 0.5 7.8e-22 77.6 0.5 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF36379.1 - 7.5e-08 32.4 12.3 1.5e-07 31.4 12.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain BBE PF08031.12 CCF36380.1 - 2.9e-08 33.7 0.0 3.8e-08 33.3 0.0 1.3 1 0 0 1 1 1 1 Berberine and berberine like DUF953 PF06110.11 CCF36380.1 - 0.061 12.9 0.2 0.078 12.6 0.2 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF953) Cytokin-bind PF09265.10 CCF36380.1 - 0.26 10.7 0.2 0.28 10.5 0.2 1.1 1 0 0 1 1 1 0 Cytokinin dehydrogenase 1, FAD and cytokinin binding Med12 PF09497.10 CCF36381.1 - 3.4e-28 97.7 0.4 1.1e-27 96.1 0.4 1.9 1 0 0 1 1 1 1 Transcription mediator complex subunit Med12 Cellulase PF00150.18 CCF36383.1 - 3.8e-19 69.2 0.4 5.1e-19 68.8 0.4 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_2_C PF02836.17 CCF36383.1 - 9.2e-05 21.7 0.0 0.00016 20.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_42 PF02449.15 CCF36383.1 - 0.0021 17.5 0.1 0.0046 16.3 0.0 1.6 2 0 0 2 2 2 1 Beta-galactosidase DUF2255 PF10012.9 CCF36383.1 - 0.048 13.8 0.6 0.12 12.5 0.5 1.8 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2255) HGTP_anticodon PF03129.20 CCF36384.1 - 1.9e-21 76.0 4.7 7.1e-21 74.2 0.1 3.2 3 0 0 3 3 3 1 Anticodon binding domain tRNA-synt_2b PF00587.25 CCF36384.1 - 3e-08 33.8 0.0 3.5e-07 30.4 0.0 2.3 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Macoilin PF09726.9 CCF36385.1 - 0.00029 19.6 28.5 0.00056 18.6 28.5 1.5 1 0 0 1 1 1 1 Macoilin family HIRAN PF08797.11 CCF36386.1 - 0.16 11.9 0.0 0.29 11.1 0.0 1.4 1 0 0 1 1 1 0 HIRAN domain R3H PF01424.22 CCF36387.1 - 2.9e-10 40.0 0.4 5.5e-10 39.1 0.4 1.4 1 0 0 1 1 1 1 R3H domain RRM_1 PF00076.22 CCF36387.1 - 1.4e-05 24.8 0.0 4.2e-05 23.3 0.0 1.8 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_2 PF04059.12 CCF36387.1 - 0.064 13.5 0.0 0.11 12.8 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif 2 Peptidase_S8 PF00082.22 CCF36389.1 - 2.2e-30 106.0 0.1 2.9e-30 105.6 0.1 1.2 1 0 0 1 1 1 1 Subtilase family PA PF02225.22 CCF36389.1 - 0.0068 16.4 0.3 0.034 14.2 0.0 2.2 2 0 0 2 2 2 1 PA domain Sugar_tr PF00083.24 CCF36390.1 - 1.5e-41 142.8 16.5 2e-41 142.3 16.5 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF36390.1 - 3.7e-32 111.6 28.5 1.4e-25 89.9 14.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_5 PF05631.14 CCF36390.1 - 0.015 14.3 2.9 0.24 10.3 0.2 2.2 2 0 0 2 2 2 0 Sugar-tranasporters, 12 TM zf-C2H2 PF00096.26 CCF36392.1 - 9.7e-08 32.1 11.6 0.00034 20.9 1.6 3.6 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCF36392.1 - 5.1e-07 30.0 10.6 0.0015 19.2 0.8 3.4 3 0 0 3 3 3 3 C2H2-type zinc finger zf-met PF12874.7 CCF36392.1 - 0.023 15.1 0.1 38 4.9 0.0 3.4 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.6 CCF36392.1 - 0.038 14.4 7.2 0.27 11.7 0.4 3.2 3 0 0 3 3 3 0 Zinc-finger double domain IBR PF01485.21 CCF36392.1 - 0.097 12.9 0.1 0.097 12.9 0.1 2.0 2 1 0 2 2 2 0 IBR domain, a half RING-finger domain zf-C2H2_aberr PF17017.5 CCF36392.1 - 0.99 9.5 2.4 0.72 10.0 0.2 1.7 1 1 1 2 2 2 0 Aberrant zinc-finger CxC6 PF18721.1 CCF36392.1 - 1.7 9.0 8.4 2.6 8.4 0.9 2.5 1 1 1 2 2 2 0 CxC6 like cysteine cluster associated with KDZ transposases zf-TRAF PF02176.18 CCF36392.1 - 5.9 7.7 7.5 1.6 9.4 0.7 2.9 1 1 1 3 3 3 0 TRAF-type zinc finger Acetyltransf_3 PF13302.7 CCF36394.1 - 7.3e-24 85.0 0.0 8.6e-24 84.8 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CCF36394.1 - 2.4e-06 27.8 0.1 0.00059 20.1 0.1 2.1 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.7 CCF36394.1 - 0.0058 16.8 0.0 0.021 15.0 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain adh_short_C2 PF13561.6 CCF36397.1 - 1.1e-21 77.5 3.0 1.6e-16 60.6 0.1 2.6 2 1 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF36397.1 - 5e-14 52.2 0.6 1.5e-08 34.4 0.1 2.3 2 0 0 2 2 2 2 short chain dehydrogenase Sacchrp_dh_NADP PF03435.18 CCF36397.1 - 6.2e-06 26.5 0.1 1.1e-05 25.8 0.1 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain KR PF08659.10 CCF36397.1 - 1.3e-05 25.2 0.2 2e-05 24.6 0.2 1.3 1 0 0 1 1 1 1 KR domain DAO PF01266.24 CCF36397.1 - 0.0056 16.3 1.7 0.01 15.4 1.7 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Peptidase_S28 PF05577.12 CCF36399.1 - 1.3e-50 172.5 0.0 7.8e-36 123.8 0.0 2.0 2 0 0 2 2 2 2 Serine carboxypeptidase S28 Stathmin PF00836.19 CCF36400.1 - 0.05 13.6 5.2 0.078 13.0 5.2 1.2 1 0 0 1 1 1 0 Stathmin family HSP70 PF00012.20 CCF36400.1 - 0.27 9.4 2.5 0.37 8.9 2.5 1.1 1 0 0 1 1 1 0 Hsp70 protein DNA_methylase PF00145.17 CCF36401.1 - 2.5e-39 135.5 0.0 2.9e-28 99.2 0.0 2.4 1 1 1 2 2 2 2 C-5 cytosine-specific DNA methylase Pectinesterase PF01095.19 CCF36402.1 - 9.6e-29 100.0 0.4 1.1e-23 83.5 1.6 2.1 2 0 0 2 2 2 2 Pectinesterase Nuc_sug_transp PF04142.15 CCF36405.1 - 4.7e-29 101.6 17.9 3.6e-25 88.8 16.9 2.3 2 0 0 2 2 2 2 Nucleotide-sugar transporter PsbH PF00737.20 CCF36405.1 - 0.006 16.3 0.1 0.026 14.3 0.1 2.1 1 0 0 1 1 1 1 Photosystem II 10 kDa phosphoprotein Pkinase PF00069.25 CCF36406.1 - 1.1e-64 218.3 0.2 1.3e-64 218.1 0.2 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF36406.1 - 6.4e-18 65.0 0.0 9e-18 64.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CCF36406.1 - 1.3e-07 31.8 0.1 1.1e-05 25.5 0.2 2.4 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CCF36406.1 - 0.0036 16.1 0.0 0.006 15.4 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 CCF36406.1 - 0.01 15.1 0.0 0.019 14.3 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Kdo PF06293.14 CCF36406.1 - 0.017 14.5 0.1 0.027 13.8 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 CCF36406.1 - 0.022 14.3 0.2 0.022 14.3 0.2 2.0 3 0 0 3 3 3 0 Choline/ethanolamine kinase Aconitase_B_N PF11791.8 CCF36406.1 - 0.18 11.9 0.0 0.52 10.4 0.0 1.7 2 0 0 2 2 2 0 Aconitate B N-terminal domain DUF3807 PF12720.7 CCF36407.1 - 1.9e-39 135.8 2.5 2.3e-39 135.5 2.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3807) CCDC106 PF15794.5 CCF36407.1 - 0.73 9.5 4.2 0.91 9.2 4.2 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 MFS_1 PF07690.16 CCF36409.1 - 6.9e-27 94.3 16.9 6.9e-27 94.3 16.9 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily CbtA PF09490.10 CCF36409.1 - 0.0084 15.9 5.0 0.35 10.6 1.1 3.1 3 0 0 3 3 3 2 Probable cobalt transporter subunit (CbtA) CD34_antigen PF06365.12 CCF36409.1 - 0.013 15.1 0.0 0.021 14.4 0.0 1.2 1 0 0 1 1 1 0 CD34/Podocalyxin family Cation_ATPase_C PF00689.21 CCF36409.1 - 0.56 9.9 0.0 0.56 9.9 0.0 3.2 2 1 2 4 4 4 0 Cation transporting ATPase, C-terminus CPP1-like PF11833.8 CCF36409.1 - 0.91 9.1 5.3 6.7 6.3 0.8 3.0 2 1 1 3 3 3 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like Alk_phosphatase PF00245.20 CCF36410.1 - 2.6e-86 290.2 0.0 3.1e-86 289.9 0.0 1.0 1 0 0 1 1 1 1 Alkaline phosphatase Methyltransf_23 PF13489.6 CCF36411.1 - 3.4e-15 56.3 0.1 4.3e-15 55.9 0.1 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF36411.1 - 6.4e-13 49.2 0.0 1.5e-12 48.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF36411.1 - 3.6e-12 46.9 0.1 9.7e-12 45.5 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF36411.1 - 4.8e-12 46.4 0.0 2.1e-11 44.3 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF36411.1 - 3.5e-10 39.9 0.0 6.4e-10 39.0 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCF36411.1 - 3.5e-09 36.4 0.0 5.8e-09 35.6 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_32 PF13679.6 CCF36411.1 - 0.0068 16.4 0.1 0.035 14.1 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain YHYH PF14240.6 CCF36411.1 - 0.022 14.7 0.9 0.029 14.3 0.9 1.2 1 0 0 1 1 1 0 YHYH protein MTS PF05175.14 CCF36411.1 - 0.092 12.3 0.0 0.66 9.5 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase small domain Acetyltransf_1 PF00583.25 CCF36412.1 - 8.5e-12 45.3 0.0 1.3e-11 44.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CCF36412.1 - 4e-09 36.8 0.0 6.1e-09 36.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CCF36412.1 - 1.4e-08 34.8 0.0 1.9e-08 34.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 CCF36412.1 - 0.024 14.7 0.0 0.11 12.5 0.0 1.9 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain FR47 PF08445.10 CCF36412.1 - 0.072 13.1 0.0 0.22 11.5 0.0 1.7 1 1 0 1 1 1 0 FR47-like protein OpcA_G6PD_assem PF10128.9 CCF36412.1 - 0.1 12.1 0.9 0.15 11.6 0.9 1.2 1 0 0 1 1 1 0 Glucose-6-phosphate dehydrogenase subunit MOZ_SAS PF01853.18 CCF36412.1 - 0.13 11.9 0.0 0.18 11.5 0.0 1.1 1 0 0 1 1 1 0 MOZ/SAS family WD40 PF00400.32 CCF36413.1 - 0.006 17.4 8.4 3.9 8.5 0.0 5.0 5 0 0 5 5 5 2 WD domain, G-beta repeat AMP-binding PF00501.28 CCF36414.1 - 5.1e-87 292.2 0.0 6.2e-87 291.9 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme MARVEL PF01284.23 CCF36416.1 - 3.5e-19 69.2 15.8 4.3e-19 69.0 15.8 1.0 1 0 0 1 1 1 1 Membrane-associating domain SDH_C PF18317.1 CCF36416.1 - 0.063 13.1 0.8 0.15 11.9 0.8 1.6 1 0 0 1 1 1 0 Shikimate 5'-dehydrogenase C-terminal domain WD40 PF00400.32 CCF36418.1 - 4.3e-08 33.7 0.1 0.052 14.4 0.0 4.3 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF36418.1 - 0.0042 17.3 0.0 12 6.3 0.0 3.7 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Spb1_C PF07780.12 CCF36420.1 - 1.6e-87 292.6 22.0 1.6e-87 292.6 22.0 3.9 3 1 0 3 3 3 1 Spb1 C-terminal domain FtsJ PF01728.19 CCF36420.1 - 6.1e-56 189.3 0.0 1.1e-55 188.5 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase DUF3381 PF11861.8 CCF36420.1 - 4.9e-52 176.1 11.0 4.9e-52 176.1 11.0 5.0 4 1 1 5 5 5 1 Domain of unknown function (DUF3381) Methyltransf_23 PF13489.6 CCF36420.1 - 6.1e-05 22.9 0.0 0.00058 19.7 0.0 2.5 2 1 0 2 2 2 1 Methyltransferase domain Metallopep PF12044.8 CCF36421.1 - 2.6e-164 546.9 0.0 3.4e-164 546.5 0.0 1.1 1 0 0 1 1 1 1 Putative peptidase family Jacalin PF01419.17 CCF36421.1 - 0.00032 20.6 0.0 0.00079 19.4 0.0 1.6 1 0 0 1 1 1 1 Jacalin-like lectin domain Reprolysin_5 PF13688.6 CCF36421.1 - 0.00056 20.1 0.2 0.0013 18.9 0.2 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_2 PF13574.6 CCF36421.1 - 0.0087 16.0 0.2 0.017 15.0 0.2 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.6 CCF36421.1 - 0.041 14.4 0.1 0.084 13.4 0.1 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like DUF3043 PF11241.8 CCF36422.1 - 0.0083 16.2 0.2 0.015 15.3 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3043) DUF3611 PF12263.8 CCF36422.1 - 0.02 14.8 0.2 0.029 14.3 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3611) WW PF00397.26 CCF36423.1 - 7.7e-09 35.5 2.3 2e-08 34.2 2.3 1.7 1 0 0 1 1 1 1 WW domain WRW PF10206.9 CCF36423.1 - 0.0059 17.0 0.3 0.011 16.0 0.3 1.4 1 0 0 1 1 1 1 Mitochondrial F1F0-ATP synthase, subunit f Fungal_trans PF04082.18 CCF36424.1 - 0.00011 21.4 0.0 0.0002 20.5 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain GATA PF00320.27 CCF36425.1 - 1.6e-29 101.2 17.9 1.6e-15 56.4 3.0 2.5 2 0 0 2 2 2 2 GATA zinc finger TF_Zn_Ribbon PF08271.12 CCF36425.1 - 3.2e-06 26.6 4.8 0.0051 16.3 0.4 2.5 2 0 0 2 2 2 2 TFIIB zinc-binding ArfGap PF01412.18 CCF36425.1 - 0.0005 20.1 1.6 0.5 10.5 0.3 2.4 2 0 0 2 2 2 2 Putative GTPase activating protein for Arf Auto_anti-p27 PF06677.12 CCF36425.1 - 0.0023 18.0 6.2 0.14 12.3 0.9 2.5 2 0 0 2 2 2 2 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Zn-ribbon_8 PF09723.10 CCF36425.1 - 0.0059 16.7 9.6 0.091 12.9 0.1 2.9 3 0 0 3 3 2 2 Zinc ribbon domain OrfB_Zn_ribbon PF07282.11 CCF36425.1 - 0.016 15.2 1.9 0.016 15.2 1.9 2.9 3 0 0 3 3 3 0 Putative transposase DNA-binding domain zf-RRN7 PF11781.8 CCF36425.1 - 0.032 13.9 9.2 0.078 12.7 0.5 2.9 2 1 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 DZR PF12773.7 CCF36425.1 - 0.18 11.8 11.8 0.51 10.4 0.2 3.1 2 1 0 2 2 2 0 Double zinc ribbon NMD3 PF04981.13 CCF36425.1 - 0.33 10.4 1.4 6 6.2 0.1 2.2 2 0 0 2 2 2 0 NMD3 family zf-CHY PF05495.12 CCF36425.1 - 0.53 10.8 2.0 9.8 6.7 0.1 2.6 2 0 0 2 2 2 0 CHY zinc finger CCDC-167 PF15188.6 CCF36425.1 - 0.76 10.2 2.5 1.8 8.9 2.5 1.6 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 eIF-5_eIF-2B PF01873.17 CCF36425.1 - 1.3 8.9 8.8 3.7 7.4 0.5 2.7 3 0 0 3 3 3 0 Domain found in IF2B/IF5 zf-Sec23_Sec24 PF04810.15 CCF36425.1 - 2.2 8.4 14.3 0.071 13.2 0.8 3.2 3 0 0 3 3 3 0 Sec23/Sec24 zinc finger COPI_assoc PF08507.10 CCF36426.1 - 4.2e-35 120.6 6.4 4.6e-35 120.5 6.4 1.0 1 0 0 1 1 1 1 COPI associated protein UCR_Fe-S_N PF10399.9 CCF36426.1 - 0.031 13.6 0.1 0.031 13.6 0.1 1.7 2 0 0 2 2 2 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal TMEM72 PF16054.5 CCF36426.1 - 0.34 10.6 5.5 0.85 9.3 1.8 2.0 2 0 0 2 2 2 0 Transmembrane protein family 72 Cg6151-P PF10233.9 CCF36426.1 - 0.46 10.8 9.6 0.82 10.0 9.5 1.5 1 1 0 1 1 1 0 Uncharacterized conserved protein CG6151-P DUF2583 PF10762.9 CCF36426.1 - 0.66 10.4 3.8 3.8 8.0 0.2 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF2583) DNA_ligase_A_M PF01068.21 CCF36427.1 - 7.2e-23 81.3 0.0 1.2e-22 80.5 0.0 1.3 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 CCF36427.1 - 1.2e-20 74.5 0.0 6.8e-20 72.1 0.0 2.0 2 0 0 2 2 2 1 DNA ligase N terminus RNA_ligase PF09414.10 CCF36427.1 - 4.2e-05 23.9 0.0 8.5e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 RNA ligase 2OG-FeII_Oxy PF03171.20 CCF36428.1 - 1.2e-11 45.0 0.0 1.8e-11 44.4 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Lipase_3 PF01764.25 CCF36429.1 - 3.7e-37 127.4 0.0 5.5e-37 126.8 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 CCF36429.1 - 0.00023 20.5 0.0 0.00042 19.7 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_8 PF06259.12 CCF36429.1 - 0.00065 19.4 0.5 0.0015 18.2 0.0 1.7 2 0 0 2 2 2 1 Alpha/beta hydrolase DUF2974 PF11187.8 CCF36429.1 - 0.0054 16.3 0.5 0.015 14.9 0.5 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF2974) Esterase PF00756.20 CCF36429.1 - 0.006 16.3 0.0 0.0095 15.6 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Abhydrolase_6 PF12697.7 CCF36429.1 - 0.0093 16.6 1.2 0.024 15.3 1.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF676 PF05057.14 CCF36429.1 - 0.063 12.8 0.0 0.098 12.2 0.0 1.2 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Cutinase PF01083.22 CCF36429.1 - 0.079 12.9 3.7 0.067 13.1 0.5 2.4 2 1 0 2 2 2 0 Cutinase Thioesterase PF00975.20 CCF36429.1 - 0.084 13.0 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 Thioesterase domain PGAP1 PF07819.13 CCF36429.1 - 0.089 12.5 0.0 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein Glyco_hydro_3 PF00933.21 CCF36430.1 - 7e-29 101.2 0.0 9.1e-29 100.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain GMC_oxred_N PF00732.19 CCF36431.1 - 5.1e-30 104.9 0.0 9.3e-30 104.0 0.0 1.4 2 0 0 2 2 2 1 GMC oxidoreductase Lycopene_cycl PF05834.12 CCF36431.1 - 0.00014 21.1 0.0 0.00017 20.8 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 CCF36431.1 - 0.00014 22.0 0.3 0.00037 20.6 0.1 1.7 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CCF36431.1 - 0.0004 20.1 0.3 0.00046 19.9 0.3 1.3 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCF36431.1 - 0.00084 18.7 0.0 0.001 18.4 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CCF36431.1 - 0.0013 18.0 0.1 0.0023 17.2 0.1 1.3 1 0 0 1 1 1 1 Thi4 family FAD_binding_2 PF00890.24 CCF36431.1 - 0.0037 16.4 0.0 0.0055 15.8 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 CCF36431.1 - 0.007 15.7 0.0 0.0099 15.2 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CCF36431.1 - 0.015 14.1 0.0 0.02 13.6 0.0 1.1 1 0 0 1 1 1 0 HI0933-like protein TrkA_N PF02254.18 CCF36431.1 - 0.072 13.4 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 TrkA-N domain NAD_binding_9 PF13454.6 CCF36431.1 - 0.14 12.1 0.3 0.4 10.7 0.1 1.8 1 1 1 2 2 2 0 FAD-NAD(P)-binding Trp_halogenase PF04820.14 CCF36431.1 - 0.16 10.8 0.0 0.23 10.2 0.0 1.3 1 0 0 1 1 1 0 Tryptophan halogenase GFA PF04828.14 CCF36432.1 - 1.4e-08 35.0 0.0 1.6e-06 28.4 0.0 2.1 2 0 0 2 2 2 2 Glutathione-dependent formaldehyde-activating enzyme DUF2415 PF10313.9 CCF36433.1 - 2.2e-05 24.3 0.0 6.4e-05 22.8 0.0 1.8 1 0 0 1 1 1 1 Uncharacterised protein domain (DUF2415) WD40 PF00400.32 CCF36433.1 - 0.02 15.7 1.3 0.3 12.0 0.4 3.2 3 0 0 3 3 3 0 WD domain, G-beta repeat Vps51 PF08700.11 CCF36433.1 - 0.22 11.6 0.2 1 9.5 0.0 2.0 2 0 0 2 2 2 0 Vps51/Vps67 RXT2_N PF08595.11 CCF36433.1 - 0.33 11.0 1.3 0.73 9.9 1.3 1.5 1 0 0 1 1 1 0 RXT2-like, N-terminal CENP-B_dimeris PF09026.10 CCF36433.1 - 9.7 6.7 15.8 6.8 7.1 9.5 2.5 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Baculo_PEP_C PF04513.12 CCF36435.1 - 0.00072 19.6 9.8 0.063 13.3 1.9 3.6 2 1 1 3 3 3 3 Baculovirus polyhedron envelope protein, PEP, C terminus ETRAMP PF09716.10 CCF36435.1 - 0.017 15.2 0.0 1.4 9.1 0.0 3.1 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) DUF2207 PF09972.9 CCF36435.1 - 0.23 10.2 4.9 0.68 8.6 0.4 2.5 3 0 0 3 3 3 0 Predicted membrane protein (DUF2207) NPV_P10 PF05531.12 CCF36435.1 - 9.9 6.7 14.9 2.9 8.4 0.2 4.9 4 2 1 5 5 5 0 Nucleopolyhedrovirus P10 protein Trp_syntA PF00290.20 CCF36436.1 - 2.3e-95 318.4 0.0 3.8e-95 317.6 0.0 1.3 1 0 0 1 1 1 1 Tryptophan synthase alpha chain PALP PF00291.25 CCF36436.1 - 8.9e-49 166.5 1.7 2.9e-48 164.8 2.2 1.6 2 0 0 2 2 2 1 Pyridoxal-phosphate dependent enzyme Ribosomal_L28 PF00830.19 CCF36437.1 - 2.7e-19 69.1 0.4 4.5e-19 68.4 0.4 1.4 1 0 0 1 1 1 1 Ribosomal L28 family DUF3439 PF11921.8 CCF36437.1 - 0.029 14.3 2.6 0.047 13.7 2.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Aminotran_1_2 PF00155.21 CCF36439.1 - 2.6e-89 299.9 0.0 2.9e-89 299.8 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Dicty_REP PF05086.12 CCF36440.1 - 0.071 11.1 0.5 0.1 10.6 0.5 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Acetyltransf_7 PF13508.7 CCF36441.1 - 7.6e-05 23.1 0.0 0.00014 22.2 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CCF36441.1 - 0.00094 19.4 0.2 0.26 11.5 0.2 3.1 2 1 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CCF36441.1 - 0.00098 19.1 0.0 0.4 10.6 0.0 2.3 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain FR47 PF08445.10 CCF36441.1 - 0.019 14.9 0.0 1.7 8.7 0.0 2.2 2 0 0 2 2 2 0 FR47-like protein Acyl-thio_N PF12590.8 CCF36442.1 - 0.005 17.4 0.3 0.01 16.4 0.3 1.5 1 0 0 1 1 1 1 Acyl-ATP thioesterase ResIII PF04851.15 CCF36443.1 - 3.3e-24 85.8 0.0 6.4e-24 84.9 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 CCF36443.1 - 8.6e-22 77.6 0.1 1.7e-21 76.6 0.1 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 CCF36443.1 - 5.6e-17 62.1 0.1 7.6e-16 58.4 0.0 2.6 2 1 1 3 3 3 1 DEAD/DEAH box helicase SWI2_SNF2 PF18766.1 CCF36443.1 - 1e-05 25.3 0.1 3e-05 23.8 0.0 1.7 2 0 0 2 2 2 1 SWI2/SNF2 ATPase AAA_22 PF13401.6 CCF36443.1 - 0.008 16.4 0.0 0.032 14.5 0.0 2.0 2 0 0 2 2 2 1 AAA domain Peptidase_M14 PF00246.24 CCF36445.1 - 3.3e-14 53.4 0.0 4.4e-14 53.0 0.0 1.3 1 0 0 1 1 1 1 Zinc carboxypeptidase AstE_AspA PF04952.14 CCF36445.1 - 0.0021 17.2 0.0 0.0029 16.7 0.0 1.3 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family DUF2119 PF09892.9 CCF36445.1 - 0.039 13.3 0.0 0.11 11.9 0.0 1.6 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2119) DUF719 PF05334.13 CCF36446.1 - 0.034 14.4 1.3 0.04 14.1 1.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF719) Presenilin PF01080.17 CCF36446.1 - 0.48 9.1 1.1 0.42 9.3 1.1 1.0 1 0 0 1 1 1 0 Presenilin DUF3659 PF12396.8 CCF36447.1 - 1.4e-17 63.3 4.8 8.9e-13 48.0 0.8 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF3659) 2OG-FeII_Oxy_2 PF13532.6 CCF36448.1 - 5.2e-14 52.9 0.0 6.5e-14 52.6 0.0 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 CCF36448.1 - 0.0033 17.9 0.0 0.0069 16.9 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily RESP18 PF14948.6 CCF36448.1 - 0.11 12.8 0.2 1.5 9.1 0.0 2.1 2 0 0 2 2 2 0 RESP18 domain Macro PF01661.21 CCF36450.1 - 2.2e-39 134.2 0.4 3.6e-39 133.4 0.4 1.4 1 0 0 1 1 1 1 Macro domain tRNA-synt_1c PF00749.21 CCF36451.1 - 8.2e-57 192.5 0.1 8.2e-57 192.5 0.1 1.4 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), catalytic domain Hc1 PF07432.13 CCF36451.1 - 0.3 11.5 15.7 0.31 11.4 14.1 1.9 2 0 0 2 2 2 0 Histone H1-like protein Hc1 AAA PF00004.29 CCF36452.1 - 1.7e-15 57.6 0.0 3.4e-15 56.6 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.11 CCF36452.1 - 1.8e-14 53.9 0.0 5.6e-14 52.3 0.0 1.9 1 0 0 1 1 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.6 CCF36452.1 - 1e-11 44.9 0.0 8.5e-11 41.9 0.0 2.2 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Rad17 PF03215.15 CCF36452.1 - 1.7e-08 34.6 0.0 3.4e-08 33.6 0.0 1.5 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_assoc_2 PF16193.5 CCF36452.1 - 6.2e-07 29.7 0.2 1.9e-06 28.1 0.0 1.9 2 0 0 2 2 1 1 AAA C-terminal domain AAA_30 PF13604.6 CCF36452.1 - 1e-06 28.6 0.5 4e-06 26.7 0.0 2.1 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.6 CCF36452.1 - 8.2e-06 26.1 0.0 4.5e-05 23.8 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CCF36452.1 - 1.2e-05 25.8 0.1 0.00012 22.5 0.0 2.5 2 2 1 3 3 3 1 AAA ATPase domain AAA_11 PF13086.6 CCF36452.1 - 1.4e-05 25.0 0.1 0.00012 22.0 0.0 2.1 1 1 0 2 2 2 1 AAA domain AAA_5 PF07728.14 CCF36452.1 - 5.1e-05 23.3 0.1 0.00015 21.8 0.1 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) DNA_pol3_delta PF06144.13 CCF36452.1 - 7.2e-05 22.6 0.1 0.00013 21.8 0.1 1.3 1 0 0 1 1 1 1 DNA polymerase III, delta subunit DUF815 PF05673.13 CCF36452.1 - 8.1e-05 21.9 0.0 0.00014 21.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_24 PF13479.6 CCF36452.1 - 0.00022 21.0 0.0 0.00041 20.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain Sigma54_activat PF00158.26 CCF36452.1 - 0.00023 20.9 0.0 0.00041 20.1 0.0 1.3 1 0 0 1 1 1 1 Sigma-54 interaction domain RuvB_N PF05496.12 CCF36452.1 - 0.00024 20.9 0.0 0.0013 18.5 0.0 2.1 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_3 PF07726.11 CCF36452.1 - 0.00037 20.4 0.1 0.0028 17.5 0.1 2.4 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.6 CCF36452.1 - 0.0004 20.7 0.1 0.0013 19.1 0.1 1.9 1 1 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 CCF36452.1 - 0.00082 18.8 0.1 0.0041 16.5 0.1 2.1 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 CCF36452.1 - 0.0013 18.7 0.0 0.0024 17.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain PhoH PF02562.16 CCF36452.1 - 0.003 17.0 1.0 0.99 8.8 0.0 2.7 2 1 0 3 3 3 1 PhoH-like protein AAA_28 PF13521.6 CCF36452.1 - 0.0042 17.3 0.0 0.0099 16.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain TniB PF05621.11 CCF36452.1 - 0.0074 15.7 0.0 0.055 12.9 0.0 2.1 2 0 0 2 2 2 1 Bacterial TniB protein AAA_7 PF12775.7 CCF36452.1 - 0.012 15.2 0.0 0.026 14.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_18 PF13238.6 CCF36452.1 - 0.012 16.1 0.0 0.022 15.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain ResIII PF04851.15 CCF36452.1 - 0.013 15.5 0.0 0.064 13.2 0.0 1.9 1 1 0 2 2 2 0 Type III restriction enzyme, res subunit ATPase_2 PF01637.18 CCF36452.1 - 0.02 14.8 0.0 0.31 10.9 0.0 2.1 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea AAA_25 PF13481.6 CCF36452.1 - 0.055 13.0 0.0 0.15 11.6 0.0 1.7 2 0 0 2 2 1 0 AAA domain MCM PF00493.23 CCF36452.1 - 0.068 12.3 0.0 0.32 10.1 0.0 2.0 1 1 0 1 1 1 0 MCM P-loop domain DEAD PF00270.29 CCF36452.1 - 0.086 12.6 0.1 0.57 9.9 0.0 2.1 1 1 1 2 2 2 0 DEAD/DEAH box helicase RNA_helicase PF00910.22 CCF36452.1 - 0.1 13.0 0.0 0.23 11.8 0.0 1.7 1 1 0 1 1 1 0 RNA helicase DUF2075 PF09848.9 CCF36452.1 - 0.12 11.5 0.0 0.25 10.5 0.0 1.4 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Fringe PF02434.16 CCF36453.1 - 5.5e-06 26.0 2.1 6.4e-05 22.5 2.1 2.3 1 1 0 1 1 1 1 Fringe-like PAN_4 PF14295.6 CCF36453.1 - 0.013 15.4 0.4 0.013 15.4 0.4 2.2 2 0 0 2 2 2 0 PAN domain Galactosyl_T PF01762.21 CCF36453.1 - 0.023 14.5 0.2 0.12 12.2 0.1 2.0 1 1 1 2 2 2 0 Galactosyltransferase Terminase_6 PF03237.15 CCF36453.1 - 0.1 12.2 0.1 0.16 11.6 0.1 1.2 1 0 0 1 1 1 0 Terminase-like family Condensation PF00668.20 CCF36454.1 - 9.3e-76 255.3 0.0 5.1e-37 127.6 0.0 4.1 4 0 0 4 4 4 4 Condensation domain AMP-binding PF00501.28 CCF36454.1 - 2.8e-17 62.4 0.0 4.5e-17 61.7 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.25 CCF36454.1 - 1.4e-11 44.5 0.1 2.9e-11 43.5 0.1 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site Transferase PF02458.15 CCF36454.1 - 0.06 12.0 0.0 0.65 8.6 0.0 2.4 3 0 0 3 3 3 0 Transferase family AMP-binding_C PF13193.6 CCF36454.1 - 0.18 12.8 0.0 0.69 10.9 0.0 2.1 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain Wzy_C PF04932.15 CCF36455.1 - 0.0044 16.7 0.8 0.0044 16.7 0.8 1.2 1 0 0 1 1 1 1 O-Antigen ligase Pex24p PF06398.11 CCF36455.1 - 0.15 11.0 0.6 0.14 11.1 0.6 1.1 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin Phage_holin_3_6 PF07332.11 CCF36455.1 - 0.94 9.5 17.0 1.2 9.2 17.0 1.2 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III FA_desaturase PF00487.24 CCF36455.1 - 8.1 6.2 9.3 17 5.1 9.3 1.7 1 1 0 1 1 1 0 Fatty acid desaturase CobD_Cbib PF03186.13 CCF36455.1 - 8.7 5.5 7.1 12 5.0 7.1 1.1 1 0 0 1 1 1 0 CobD/Cbib protein DUF4131 PF13567.6 CCF36455.1 - 9.3 5.9 9.7 13 5.4 9.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) DUF4960 PF16324.5 CCF36456.1 - 0.029 13.9 0.0 0.029 13.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4960) BCAS2 PF05700.11 CCF36460.1 - 4.9e-57 193.0 5.4 5.8e-57 192.7 5.4 1.0 1 0 0 1 1 1 1 Breast carcinoma amplified sequence 2 (BCAS2) cNMP_binding PF00027.29 CCF36461.1 - 2.8e-41 139.5 0.0 6.4e-22 77.4 0.0 2.3 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Sugar_tr PF00083.24 CCF36463.1 - 4.4e-58 197.2 20.8 5e-58 197.0 20.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF36463.1 - 4.1e-19 68.7 33.3 4.1e-19 68.7 33.3 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Nuc_H_symport PF03825.16 CCF36463.1 - 0.00031 19.8 3.4 0.00031 19.8 3.4 2.2 2 0 0 2 2 2 1 Nucleoside H+ symporter MFS_1_like PF12832.7 CCF36463.1 - 3 6.6 15.8 0.06 12.2 5.4 2.3 2 0 0 2 2 2 0 MFS_1 like family Sugar_tr PF00083.24 CCF36464.1 - 4.1e-99 332.5 28.2 4.7e-98 329.0 28.2 1.9 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF36464.1 - 1e-30 106.9 10.4 1e-30 106.9 10.4 2.4 1 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 CCF36464.1 - 0.00011 20.8 0.7 0.00011 20.8 0.7 1.9 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) GH115_C PF17829.1 CCF36465.1 - 4.5e-21 75.4 0.0 8.5e-21 74.5 0.0 1.4 1 0 0 1 1 1 1 Gylcosyl hydrolase family 115 C-terminal domain Glyco_hydro_115 PF15979.5 CCF36465.1 - 3e-09 36.8 0.3 4.3e-09 36.3 0.3 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 115 ELFV_dehydrog PF00208.21 CCF36466.1 - 3.7e-14 53.0 0.0 4.2e-14 52.9 0.0 1.0 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Pyr_redox_2 PF07992.14 CCF36467.1 - 0.027 13.7 0.2 0.039 13.2 0.2 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCF36467.1 - 0.053 13.7 0.3 0.12 12.6 0.3 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain DUF3530 PF12048.8 CCF36467.1 - 0.12 11.8 0.0 0.14 11.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) PSY3 PF16836.5 CCF36467.1 - 0.24 10.9 0.0 0.33 10.4 0.0 1.1 1 0 0 1 1 1 0 Shu complex component Psy3, DNA-binding description Itfg2 PF15907.5 CCF36468.1 - 0.16 11.0 0.0 0.2 10.6 0.0 1.1 1 0 0 1 1 1 0 Integrin-alpha FG-GAP repeat-containing protein 2 Cellulase PF00150.18 CCF36469.1 - 6.2e-45 153.8 0.2 8.4e-45 153.4 0.2 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) CBM_1 PF00734.18 CCF36469.1 - 1.9e-11 43.7 10.3 1.9e-11 43.7 10.3 2.5 2 0 0 2 2 2 1 Fungal cellulose binding domain PQ-loop PF04193.14 CCF36470.1 - 3.2e-37 126.1 13.0 2.1e-20 72.2 0.1 3.0 3 1 0 3 3 3 2 PQ loop repeat TMEM132D_C PF15706.5 CCF36470.1 - 0.14 12.0 0.0 0.3 10.9 0.0 1.6 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term DUF2637 PF10935.8 CCF36470.1 - 1.5 8.7 5.3 12 5.8 0.9 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2637) S1-P1_nuclease PF02265.16 CCF36471.1 - 7.9e-72 242.1 0.0 9.2e-72 241.9 0.0 1.0 1 0 0 1 1 1 1 S1/P1 Nuclease PSI_PSAK PF01241.18 CCF36471.1 - 0.025 14.6 0.6 0.058 13.4 0.6 1.5 1 0 0 1 1 1 0 Photosystem I psaG / psaK VPDSG-CTERM PF18205.1 CCF36471.1 - 0.11 12.3 0.7 0.25 11.2 0.7 1.6 1 0 0 1 1 1 0 VPDSG-CTERM motif Ndc1_Nup PF09531.10 CCF36473.1 - 1.1 7.9 6.3 1.1 7.8 6.3 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup HET PF06985.11 CCF36474.1 - 1.1e-34 119.9 0.6 1.6e-34 119.4 0.6 1.3 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Fungal_trans PF04082.18 CCF36475.1 - 1.6e-11 43.8 0.3 2.9e-11 42.9 0.3 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF36475.1 - 2.8e-06 27.3 11.7 5.3e-06 26.5 11.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PSK PF06404.12 CCF36476.1 - 0.21 12.6 4.0 12 7.0 0.2 2.5 3 0 0 3 3 3 0 Phytosulfokine precursor protein (PSK) Sulfotransfer_4 PF17784.1 CCF36477.1 - 3e-59 200.4 0.2 3.5e-59 200.2 0.2 1.0 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 CCF36477.1 - 0.0012 19.3 0.1 0.0017 18.8 0.1 1.4 1 0 0 1 1 1 1 Sulfotransferase family MFS_1 PF07690.16 CCF36478.1 - 1.7e-26 93.0 19.9 2.7e-26 92.4 19.9 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_1_like PF12832.7 CCF36478.1 - 6.9e-08 31.7 4.8 0.0002 20.4 0.2 2.1 2 0 0 2 2 2 2 MFS_1 like family Sugar_tr PF00083.24 CCF36478.1 - 0.00029 19.8 2.1 0.00029 19.8 2.1 2.0 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_2 PF13347.6 CCF36478.1 - 0.0027 16.3 2.4 0.0027 16.3 2.4 2.8 3 1 0 3 3 3 2 MFS/sugar transport protein TRI12 PF06609.13 CCF36478.1 - 0.0042 15.6 2.8 0.0067 14.9 2.8 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Peptidase_U4 PF03419.13 CCF36478.1 - 4.2 6.6 11.4 6.1 6.1 5.2 2.3 2 0 0 2 2 2 0 Sporulation factor SpoIIGA Ank_4 PF13637.6 CCF36479.1 - 1.3e-11 44.7 0.2 5.3e-09 36.4 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCF36479.1 - 1.2e-07 31.4 0.1 0.00045 20.5 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.7 CCF36479.1 - 1.8e-07 31.7 0.0 3.1e-07 30.9 0.0 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 CCF36479.1 - 1.4e-06 28.5 0.9 0.00014 22.1 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.6 CCF36479.1 - 0.00012 22.3 0.1 0.00026 21.2 0.1 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) FAA_hydrolase PF01557.18 CCF36480.1 - 4.8e-60 202.9 0.0 6e-60 202.6 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FAD_binding_3 PF01494.19 CCF36481.1 - 1e-28 100.6 0.0 1.4e-28 100.2 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 CCF36481.1 - 7.5e-11 42.2 4.4 3e-05 23.8 2.8 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCF36481.1 - 3.7e-10 39.5 0.0 0.00011 21.5 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCF36481.1 - 3.3e-08 33.6 0.6 1.4e-07 31.7 0.3 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 CCF36481.1 - 1e-06 28.1 1.1 1.6e-06 27.4 0.7 1.6 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.14 CCF36481.1 - 2.5e-06 26.5 0.2 0.0033 16.2 0.4 2.2 2 0 0 2 2 2 2 HI0933-like protein Trp_halogenase PF04820.14 CCF36481.1 - 6.3e-06 25.3 0.2 3.8e-05 22.7 0.1 2.0 1 1 1 2 2 2 1 Tryptophan halogenase Pyr_redox PF00070.27 CCF36481.1 - 8.2e-06 26.3 0.0 0.00046 20.7 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 CCF36481.1 - 4.1e-05 22.8 1.2 0.2 10.6 0.0 2.1 2 0 0 2 2 2 2 Lycopene cyclase protein Amino_oxidase PF01593.24 CCF36481.1 - 9e-05 21.9 0.5 0.4 9.9 0.3 2.3 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase FAD_oxidored PF12831.7 CCF36481.1 - 0.00025 20.6 1.1 0.00049 19.6 1.1 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 CCF36481.1 - 0.0022 17.3 1.0 0.0089 15.3 0.7 2.0 2 0 0 2 2 2 1 Thi4 family GIDA PF01134.22 CCF36481.1 - 0.0066 15.6 1.1 0.011 14.9 1.1 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 CCF36481.1 - 0.016 14.5 0.7 0.029 13.6 0.7 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CCF36481.1 - 0.025 14.6 0.2 0.083 12.9 0.2 2.0 1 1 0 1 1 1 0 FAD-NAD(P)-binding SE PF08491.10 CCF36481.1 - 0.082 12.0 0.0 0.16 11.0 0.0 1.5 1 1 0 1 1 1 0 Squalene epoxidase NAD_binding_7 PF13241.6 CCF36481.1 - 0.16 12.4 0.0 0.38 11.2 0.0 1.7 1 1 0 1 1 1 0 Putative NAD(P)-binding AlaDh_PNT_C PF01262.21 CCF36481.1 - 0.21 10.9 1.6 4.5 6.5 1.1 2.5 2 1 1 3 3 3 0 Alanine dehydrogenase/PNT, C-terminal domain PNP_UDP_1 PF01048.20 CCF36482.1 - 1.2e-09 37.8 3.5 2.2e-08 33.7 3.5 2.5 1 1 0 1 1 1 1 Phosphorylase superfamily AAA PF00004.29 CCF36483.1 - 4e-16 59.7 0.0 7.1e-16 58.8 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CCF36483.1 - 0.00056 20.2 0.6 0.0086 16.4 0.1 2.7 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 CCF36483.1 - 0.0026 18.2 0.0 0.0073 16.7 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_30 PF13604.6 CCF36483.1 - 0.045 13.5 0.0 0.096 12.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 CCF36483.1 - 0.049 13.6 0.0 0.23 11.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_19 PF13245.6 CCF36483.1 - 0.061 13.7 0.4 0.23 11.8 0.1 2.0 2 0 0 2 2 2 0 AAA domain Fungal_trans PF04082.18 CCF36485.1 - 2.6e-16 59.4 0.1 2.9e-16 59.3 0.1 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain Nairovirus_M PF07948.11 CCF36485.1 - 0.11 10.7 0.0 0.13 10.4 0.0 1.0 1 0 0 1 1 1 0 Nairovirus M polyprotein-like Scytalone_dh PF02982.14 CCF36486.1 - 2.4e-95 316.7 1.0 2.8e-95 316.5 1.0 1.0 1 0 0 1 1 1 1 Scytalone dehydratase SnoaL_4 PF13577.6 CCF36486.1 - 2e-07 31.2 0.2 2.7e-07 30.8 0.2 1.2 1 0 0 1 1 1 1 SnoaL-like domain Cyt-b5 PF00173.28 CCF36488.1 - 1.6e-13 50.6 0.0 2.1e-13 50.2 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain TPR_17 PF13431.6 CCF36489.1 - 0.018 15.4 0.0 12 6.6 0.0 3.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_9 PF13371.6 CCF36489.1 - 0.056 13.6 0.8 0.41 10.8 0.8 2.5 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_11 PF13414.6 CCF36489.1 - 0.16 11.6 6.1 13 5.5 0.1 4.1 5 0 0 5 5 5 0 TPR repeat TPR_8 PF13181.6 CCF36489.1 - 0.17 12.2 1.4 38 4.8 0.1 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 CCF36489.1 - 0.3 12.0 14.7 6.6 7.8 0.2 5.7 4 1 2 6 6 6 0 Tetratricopeptide repeat MAGI_u1 PF16663.5 CCF36489.1 - 0.82 9.8 8.7 6.3 7.0 1.2 2.7 2 0 0 2 2 2 0 Unstructured region on MAGI TPR_16 PF13432.6 CCF36489.1 - 0.89 10.3 13.0 4.8 7.9 0.3 4.4 4 1 0 4 4 4 0 Tetratricopeptide repeat DUF1439 PF07273.12 CCF36489.1 - 0.96 9.3 3.7 13 5.6 0.1 3.4 4 0 0 4 4 4 0 Protein of unknown function (DUF1439) ChAPs PF09295.10 CCF36490.1 - 3.3e-10 39.5 0.2 3.9e-10 39.3 0.2 1.1 1 0 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) Methyltransf_23 PF13489.6 CCF36491.1 - 7.8e-19 68.1 0.0 1.5e-18 67.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF36491.1 - 4.2e-13 49.8 0.0 1.5e-12 48.0 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF36491.1 - 3e-11 43.3 0.0 0.00013 21.7 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 CCF36491.1 - 7.8e-11 42.5 0.0 1.7e-10 41.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF36491.1 - 1.5e-08 35.3 0.0 2.1e-07 31.6 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCF36491.1 - 3.9e-05 23.1 0.0 0.14 11.4 0.0 2.2 2 0 0 2 2 2 2 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 CCF36491.1 - 0.002 17.6 0.0 0.0041 16.6 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase PrmA PF06325.13 CCF36491.1 - 0.0026 17.2 0.0 0.0049 16.3 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 CCF36491.1 - 0.0032 17.0 0.0 0.0061 16.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain FtsJ PF01728.19 CCF36491.1 - 0.022 14.9 0.0 0.041 14.0 0.0 1.6 1 0 0 1 1 1 0 FtsJ-like methyltransferase DUF938 PF06080.12 CCF36491.1 - 0.037 13.8 0.0 0.075 12.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Tannase PF07519.11 CCF36492.1 - 3.3e-81 273.6 0.0 3.7e-81 273.4 0.0 1.0 1 0 0 1 1 1 1 Tannase and feruloyl esterase Peptidase_S9 PF00326.21 CCF36492.1 - 2.4e-05 23.9 0.2 0.066 12.7 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 CCF36492.1 - 0.019 14.6 0.1 0.07 12.8 0.0 1.8 2 0 0 2 2 2 0 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CCF36492.1 - 0.05 12.9 0.0 0.097 11.9 0.0 1.4 2 0 0 2 2 2 0 Serine aminopeptidase, S33 ketoacyl-synt PF00109.26 CCF36493.1 - 1.8e-59 201.4 0.0 2e-59 201.2 0.0 1.0 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Thiolase_N PF00108.23 CCF36493.1 - 0.00026 20.4 0.1 0.00039 19.9 0.1 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain ACP_syn_III PF08545.10 CCF36493.1 - 0.13 12.2 0.8 0.22 11.4 0.8 1.3 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Methyltransf_23 PF13489.6 CCF36494.1 - 7.4e-19 68.2 0.0 1.2e-18 67.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF36494.1 - 4.2e-10 40.2 0.0 1.7e-09 38.3 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF36494.1 - 3.6e-08 33.9 0.0 7.3e-08 33.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF36494.1 - 1.1e-07 31.8 0.0 0.0042 16.9 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 CCF36494.1 - 2.9e-07 31.1 0.1 3.4e-06 27.7 0.1 2.3 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CCF36494.1 - 0.024 14.2 0.0 0.051 13.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_2 PF00891.18 CCF36494.1 - 0.078 12.3 0.0 0.23 10.7 0.0 1.8 2 0 0 2 2 2 0 O-methyltransferase domain PrmA PF06325.13 CCF36494.1 - 0.092 12.1 0.0 0.16 11.3 0.0 1.4 1 1 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) ABC_tran PF00005.27 CCF36495.1 - 3.1e-46 157.3 2.7 1.8e-24 86.8 0.1 2.5 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 CCF36495.1 - 3.2e-16 60.0 0.3 0.00014 21.8 0.0 4.3 3 1 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CCF36495.1 - 5e-11 42.4 3.0 0.0015 18.0 0.0 4.2 3 1 1 4 4 4 3 RecF/RecN/SMC N terminal domain ABC2_membrane_3 PF12698.7 CCF36495.1 - 1.7e-08 34.0 64.3 1.9e-08 33.8 20.1 3.1 3 1 0 3 3 3 2 ABC-2 family transporter protein AAA_23 PF13476.6 CCF36495.1 - 3e-06 27.9 1.1 0.024 15.2 0.2 2.3 2 0 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 CCF36495.1 - 1.3e-05 25.2 0.6 0.0035 17.3 0.2 2.6 2 0 0 2 2 2 1 RsgA GTPase AAA_29 PF13555.6 CCF36495.1 - 1.6e-05 24.6 0.7 0.095 12.5 0.1 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain NB-ARC PF00931.22 CCF36495.1 - 0.00011 21.4 3.5 0.95 8.6 0.2 3.5 3 1 0 3 3 3 2 NB-ARC domain AAA_22 PF13401.6 CCF36495.1 - 0.00027 21.2 0.1 0.88 9.8 0.0 3.1 3 0 0 3 3 3 2 AAA domain IstB_IS21 PF01695.17 CCF36495.1 - 0.00028 20.7 0.1 20 4.8 0.0 4.4 4 0 0 4 4 4 0 IstB-like ATP binding protein AAA_30 PF13604.6 CCF36495.1 - 0.00051 19.8 0.7 0.96 9.1 0.0 2.9 2 1 0 2 2 2 2 AAA domain AAA_16 PF13191.6 CCF36495.1 - 0.00098 19.5 0.1 0.15 12.4 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain SbcCD_C PF13558.6 CCF36495.1 - 0.0026 18.0 0.2 3.4 8.0 0.1 3.8 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit SRP54 PF00448.22 CCF36495.1 - 0.0078 15.9 1.8 1.6 8.3 0.1 2.5 2 0 0 2 2 2 2 SRP54-type protein, GTPase domain TsaE PF02367.17 CCF36495.1 - 0.018 15.0 0.2 0.36 10.8 0.0 2.3 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA PF00004.29 CCF36495.1 - 0.019 15.4 1.1 11 6.4 0.5 3.4 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 CCF36495.1 - 0.02 14.6 0.0 4.3 7.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 CCF36495.1 - 0.02 14.2 0.5 2.6 7.3 0.0 2.5 2 0 0 2 2 2 0 Zeta toxin MukB PF04310.12 CCF36495.1 - 0.024 14.4 0.2 1 9.1 0.1 2.3 2 0 0 2 2 2 0 MukB N-terminal AAA_15 PF13175.6 CCF36495.1 - 0.042 13.6 0.1 5.2 6.7 0.1 2.6 3 0 0 3 3 3 0 AAA ATPase domain AAA_13 PF13166.6 CCF36495.1 - 0.049 12.3 0.1 5.3 5.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_27 PF13514.6 CCF36495.1 - 0.064 12.8 0.1 6.6 6.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain DUF4162 PF13732.6 CCF36495.1 - 0.087 13.6 0.0 0.33 11.7 0.0 2.0 2 0 0 2 2 1 0 Domain of unknown function (DUF4162) Rad17 PF03215.15 CCF36495.1 - 0.13 12.2 0.1 12 5.8 0.0 2.3 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_14 PF13173.6 CCF36495.1 - 0.17 11.9 0.0 15 5.7 0.0 2.6 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 CCF36495.1 - 0.19 12.1 0.1 9.3 6.7 0.0 2.6 2 0 0 2 2 2 0 RNA helicase Mg_chelatase PF01078.21 CCF36495.1 - 0.23 10.8 0.4 15 4.9 0.1 2.8 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI DUF1793 PF08760.11 CCF36496.1 - 5.6e-73 244.9 1.2 6.6e-73 244.6 1.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1793) RRM_1 PF00076.22 CCF36497.1 - 6e-21 74.0 0.0 8.5e-21 73.6 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CCF36497.1 - 2.3e-05 24.0 0.0 3.3e-05 23.5 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF3450 PF11932.8 CCF36498.1 - 5.8e-05 22.5 21.5 0.0003 20.2 7.6 5.4 2 2 2 5 5 5 3 Protein of unknown function (DUF3450) KASH_CCD PF14662.6 CCF36498.1 - 8.4e-05 22.5 19.3 8.4e-05 22.5 19.3 4.9 1 1 3 4 4 3 2 Coiled-coil region of CCDC155 or KASH HALZ PF02183.18 CCF36498.1 - 0.00019 21.6 41.7 0.00068 19.8 0.6 8.3 7 3 1 9 9 8 3 Homeobox associated leucine zipper Spc7 PF08317.11 CCF36498.1 - 0.00085 18.3 14.9 0.00085 18.3 14.9 3.9 1 1 2 3 3 3 1 Spc7 kinetochore protein APG6_N PF17675.1 CCF36498.1 - 0.0011 19.5 11.9 0.0011 19.5 11.9 6.1 2 1 3 5 5 5 1 Apg6 coiled-coil region ERM PF00769.19 CCF36498.1 - 0.0039 17.0 14.7 0.0039 17.0 14.7 4.4 1 1 3 4 4 3 1 Ezrin/radixin/moesin family ADIP PF11559.8 CCF36498.1 - 0.02 15.0 1.8 0.02 15.0 1.8 6.2 2 2 4 6 6 5 0 Afadin- and alpha -actinin-Binding FPP PF05911.11 CCF36498.1 - 0.028 12.6 57.8 0.068 11.4 25.2 2.6 1 1 0 2 2 2 0 Filament-like plant protein, long coiled-coil GAS PF13851.6 CCF36498.1 - 0.03 13.7 64.3 0.046 13.1 17.5 4.4 1 1 4 5 5 5 0 Growth-arrest specific micro-tubule binding bZIP_2 PF07716.15 CCF36498.1 - 0.16 12.1 0.1 0.16 12.1 0.1 10.2 7 2 6 14 14 14 0 Basic region leucine zipper DUF3584 PF12128.8 CCF36498.1 - 0.43 8.0 58.5 0.27 8.7 41.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) DUF1664 PF07889.12 CCF36498.1 - 1.1 9.3 39.2 0.52 10.3 4.7 5.6 2 1 3 5 5 5 0 Protein of unknown function (DUF1664) BLOC1_2 PF10046.9 CCF36498.1 - 3 8.2 35.9 0.41 11.0 7.8 6.3 2 2 5 7 7 7 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 HMMR_N PF15905.5 CCF36498.1 - 5.3 6.4 64.7 0.76 9.2 22.5 4.1 1 1 3 4 4 4 0 Hyaluronan mediated motility receptor N-terminal DUF5082 PF16888.5 CCF36498.1 - 8.1 6.7 54.7 0.25 11.6 2.0 7.7 3 2 3 7 7 7 0 Domain of unknown function (DUF5082) Golgin_A5 PF09787.9 CCF36498.1 - 9.2 5.6 60.1 0.12 11.9 19.5 4.0 1 1 3 4 4 4 0 Golgin subfamily A member 5 MbeD_MobD PF04899.12 CCF36498.1 - 9.2 6.5 12.7 57 3.9 0.3 5.3 3 2 2 5 5 5 0 MbeD/MobD like Sugar_tr PF00083.24 CCF36499.1 - 7.3e-73 246.0 17.1 8.9e-73 245.7 17.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF36499.1 - 3.3e-23 82.2 17.9 3.3e-23 82.2 17.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF373 PF04123.13 CCF36499.1 - 4.3 6.7 5.3 2.9 7.2 2.7 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF373) Ldl_recept_b PF00058.17 CCF36500.1 - 5.7e-11 42.7 7.8 0.004 17.6 0.0 5.7 5 1 0 5 5 5 3 Low-density lipoprotein receptor repeat class B SGL PF08450.12 CCF36500.1 - 7.1e-05 22.5 0.3 0.69 9.4 0.0 3.0 1 1 1 3 3 3 2 SMP-30/Gluconolactonase/LRE-like region He_PIG PF05345.12 CCF36500.1 - 0.0044 17.2 1.0 0.45 10.8 0.1 2.9 3 0 0 3 3 3 1 Putative Ig domain DUF5074 PF16819.5 CCF36500.1 - 0.15 12.1 0.0 0.44 10.6 0.0 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF5074) 3HCDH_N PF02737.18 CCF36501.1 - 2.3e-50 171.0 0.0 3.1e-50 170.6 0.0 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 CCF36501.1 - 3.3e-16 59.7 0.0 6.4e-16 58.8 0.0 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain UDPG_MGDP_dh_N PF03721.14 CCF36501.1 - 4.8e-05 23.0 0.0 8.9e-05 22.1 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 2-Hacid_dh_C PF02826.19 CCF36501.1 - 0.00061 19.2 0.0 0.0051 16.2 0.0 2.2 1 1 1 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.23 CCF36501.1 - 0.0018 18.3 0.1 0.0052 16.8 0.1 1.7 1 1 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus ApbA PF02558.16 CCF36501.1 - 0.002 17.8 0.1 0.0059 16.3 0.1 1.8 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA NAD_binding_2 PF03446.15 CCF36501.1 - 0.018 15.2 0.0 0.05 13.8 0.0 1.9 1 1 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase TrkA_N PF02254.18 CCF36501.1 - 0.019 15.2 0.0 0.24 11.7 0.0 2.5 2 0 0 2 2 2 0 TrkA-N domain IlvN PF07991.12 CCF36501.1 - 0.063 12.9 0.1 0.5 9.9 0.1 2.2 1 1 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain FAD_binding_3 PF01494.19 CCF36501.1 - 0.093 12.0 0.0 0.14 11.4 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain Pyr_redox PF00070.27 CCF36501.1 - 0.14 12.8 0.7 0.4 11.3 0.1 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase F420_oxidored PF03807.17 CCF36501.1 - 0.16 12.6 0.4 0.57 10.8 0.4 2.1 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Tn916-Xis PF09035.10 CCF36501.1 - 0.17 12.1 0.0 0.34 11.1 0.0 1.4 1 0 0 1 1 1 0 Excisionase from transposon Tn916 TRP PF06011.12 CCF36502.1 - 1.4e-20 73.5 17.4 2.3e-13 49.7 11.9 2.1 2 0 0 2 2 2 2 Transient receptor potential (TRP) ion channel EMC3_TMCO1 PF01956.16 CCF36502.1 - 0.61 9.8 6.6 1.6 8.4 0.3 3.2 3 0 0 3 3 3 0 Integral membrane protein EMC3/TMCO1-like ATP-synt_C PF00137.21 CCF36504.1 - 4.9e-11 42.8 13.0 4.9e-11 42.8 13.0 1.8 2 0 0 2 2 2 1 ATP synthase subunit C MOZ_SAS PF01853.18 CCF36505.1 - 2.3e-54 183.8 0.0 3.3e-54 183.3 0.0 1.1 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 CCF36505.1 - 3.7e-08 32.9 0.2 0.0085 15.7 0.2 2.4 2 0 0 2 2 2 2 MYST family zinc finger domain Acetyltransf_7 PF13508.7 CCF36505.1 - 0.15 12.5 0.0 0.46 11.0 0.0 1.7 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain FAD_binding_1 PF00667.20 CCF36506.1 - 1e-61 208.3 0.0 3e-61 206.8 0.0 1.8 2 0 0 2 2 2 1 FAD binding domain POR PF01558.18 CCF36506.1 - 5.9e-10 39.5 0.0 1.5e-09 38.2 0.0 1.6 1 0 0 1 1 1 1 Pyruvate ferredoxin/flavodoxin oxidoreductase NAD_binding_1 PF00175.21 CCF36506.1 - 7.2e-09 36.3 0.0 1.7e-08 35.0 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain PFOR_II PF17147.4 CCF36506.1 - 6.1e-08 32.9 0.1 2e-07 31.3 0.1 1.9 1 0 0 1 1 1 1 Pyruvate:ferredoxin oxidoreductase core domain II LLC1 PF14945.6 CCF36506.1 - 0.0028 18.2 0.0 0.0056 17.2 0.0 1.5 1 0 0 1 1 1 1 Normal lung function maintenance, Low in Lung Cancer 1 protein Transketolase_C PF02780.20 CCF36506.1 - 0.0091 15.9 0.1 0.022 14.6 0.1 1.6 1 0 0 1 1 1 1 Transketolase, C-terminal domain Fe-ADH PF00465.19 CCF36507.1 - 9.9e-100 333.9 0.0 1.2e-99 333.5 0.0 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 CCF36507.1 - 3.5e-13 49.8 0.0 2e-10 40.8 0.0 2.3 2 0 0 2 2 2 2 Iron-containing alcohol dehydrogenase Peripla_BP_6 PF13458.6 CCF36507.1 - 0.0028 17.4 0.1 0.0046 16.7 0.1 1.3 1 0 0 1 1 1 1 Periplasmic binding protein Peptidase_S58 PF03576.14 CCF36508.1 - 4.8e-116 387.5 0.5 5.4e-116 387.3 0.5 1.0 1 0 0 1 1 1 1 Peptidase family S58 tRNA-synt_2 PF00152.20 CCF36509.1 - 4.5e-74 249.3 0.5 6e-74 248.9 0.5 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 CCF36509.1 - 7.7e-10 38.6 0.2 2.1e-09 37.2 0.1 1.9 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 CCF36509.1 - 1.7e-05 24.4 0.4 0.054 13.0 0.1 2.2 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) DUF2956 PF11169.8 CCF36509.1 - 0.16 12.2 3.2 0.4 10.9 3.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2956) UCR_Fe-S_N PF10399.9 CCF36509.1 - 0.18 11.2 0.0 0.33 10.3 0.0 1.4 1 0 0 1 1 1 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal COX15-CtaA PF02628.15 CCF36510.1 - 4.7e-112 374.2 3.6 5.8e-112 373.9 3.6 1.1 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein Utp14 PF04615.13 CCF36511.1 - 1.2e-193 645.8 64.0 1.2e-193 645.8 64.0 2.2 1 1 1 2 2 2 1 Utp14 protein Na_Ca_ex PF01699.24 CCF36512.1 - 5.7e-46 156.2 33.8 6.3e-25 87.9 14.0 2.2 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Glyco_hydro81C PF17652.1 CCF36513.1 - 1.4e-159 531.0 2.3 1.7e-159 530.7 2.3 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 C-terminal domain Glyco_hydro_81 PF03639.13 CCF36513.1 - 2.6e-117 391.6 0.6 3.3e-117 391.2 0.6 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 N-terminal domain RTA1 PF04479.13 CCF36514.1 - 2.2e-26 92.7 7.8 3e-26 92.3 7.8 1.2 1 0 0 1 1 1 1 RTA1 like protein CENP-R PF06729.12 CCF36514.1 - 0.28 11.1 2.8 0.39 10.6 2.8 1.2 1 0 0 1 1 1 0 Kinetochore component, CENP-R Rhomboid PF01694.22 CCF36515.1 - 9.6e-19 67.9 2.5 1.9e-18 66.9 2.5 1.4 1 0 0 1 1 1 1 Rhomboid family Amastin PF07344.11 CCF36516.1 - 0.017 15.0 2.2 0.023 14.5 2.2 1.3 1 0 0 1 1 1 0 Amastin surface glycoprotein DUF2231 PF09990.9 CCF36516.1 - 0.049 14.1 3.9 0.17 12.4 0.2 2.0 1 1 1 2 2 2 0 Predicted membrane protein (DUF2231) Adeno_E3_14_5 PF04834.12 CCF36516.1 - 0.05 14.1 0.7 0.07 13.7 0.7 1.3 1 0 0 1 1 1 0 Early E3 14.5 kDa protein AKAP28 PF14469.6 CCF36519.1 - 0.023 14.4 0.1 0.16 11.8 0.1 2.1 2 0 0 2 2 2 0 28 kDa A-kinase anchor PHA_gran_rgn PF09650.10 CCF36519.1 - 0.031 14.6 0.1 0.12 12.7 0.1 2.0 1 0 0 1 1 1 0 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn) AMP-binding PF00501.28 CCF36521.1 - 2.1e-56 191.3 0.8 2.8e-56 190.9 0.8 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CCF36521.1 - 7.9e-26 90.8 0.5 1.5e-25 89.9 0.5 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain SNF2_N PF00176.23 CCF36522.1 - 1.2e-43 149.2 0.0 2e-43 148.4 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CCF36522.1 - 1.4e-12 47.9 0.0 4.3e-12 46.4 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 CCF36522.1 - 7.1e-06 25.4 0.0 1.4e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase zf-C3HC4_3 PF13920.6 CCF36522.1 - 0.0034 17.2 10.6 0.0066 16.3 10.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_13 PF17977.1 CCF36522.1 - 0.3 11.2 8.0 1.9 8.7 7.9 2.1 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.6 CCF36522.1 - 0.3 11.3 8.8 0.9 9.8 8.8 1.9 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 CCF36522.1 - 0.49 10.3 9.9 1 9.3 9.9 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Tmemb_55A PF09788.9 CCF36522.1 - 0.61 9.1 4.4 0.93 8.5 3.1 1.8 2 0 0 2 2 2 0 Transmembrane protein 55A zf-RING_2 PF13639.6 CCF36522.1 - 0.98 9.8 9.6 2.1 8.7 9.6 1.6 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4 PF00097.25 CCF36522.1 - 1.1 9.2 9.4 2.3 8.1 9.4 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CCF36522.1 - 1.8 8.6 9.5 4.2 7.4 9.5 1.6 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_UBOX PF13445.6 CCF36522.1 - 2.7 8.1 5.9 7.1 6.7 5.9 1.7 1 0 0 1 1 1 0 RING-type zinc-finger IBR PF01485.21 CCF36523.1 - 5.6e-12 45.7 35.7 2.1e-06 27.9 12.8 2.4 2 0 0 2 2 2 2 IBR domain, a half RING-finger domain Methyltransf_16 PF10294.9 CCF36524.1 - 2.5e-18 66.4 0.0 5.9e-18 65.2 0.0 1.6 2 0 0 2 2 2 1 Lysine methyltransferase Methyltransf_23 PF13489.6 CCF36524.1 - 0.0017 18.2 0.0 0.0027 17.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 CCF36524.1 - 0.019 14.4 0.0 0.039 13.3 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 CCF36524.1 - 0.022 14.3 0.0 0.059 12.9 0.0 1.8 1 1 1 2 2 2 0 Methyltransferase small domain Methyltransf_25 PF13649.6 CCF36524.1 - 0.043 14.5 0.0 0.11 13.2 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain AZUL PF16558.5 CCF36528.1 - 0.018 15.2 0.0 0.034 14.4 0.0 1.4 1 0 0 1 1 1 0 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A SET PF00856.28 CCF36529.1 - 1.5e-09 38.5 0.0 2.3e-09 37.9 0.0 1.4 1 0 0 1 1 1 1 SET domain FtsJ PF01728.19 CCF36530.1 - 4.7e-62 209.2 0.0 6.2e-62 208.8 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase DUF5004 PF16395.5 CCF36530.1 - 0.095 12.7 0.0 0.27 11.2 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF5004) Acetyltransf_1 PF00583.25 CCF36531.1 - 2.2e-09 37.6 0.0 2.6e-09 37.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CCF36531.1 - 8.4e-06 25.7 0.0 1.3e-05 25.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CCF36531.1 - 0.00011 22.5 0.0 0.00017 22.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CCF36531.1 - 0.024 14.6 0.0 0.039 13.9 0.0 1.3 1 0 0 1 1 1 0 FR47-like protein SnoaL_2 PF12680.7 CCF36532.1 - 0.069 13.8 0.1 0.11 13.1 0.1 1.4 1 0 0 1 1 1 0 SnoaL-like domain DUF2576 PF10845.8 CCF36532.1 - 6.9 6.4 8.4 4.5 6.9 0.1 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF2576) BAR PF03114.18 CCF36533.1 - 1.4e-69 234.4 8.9 1.7e-69 234.1 8.9 1.1 1 0 0 1 1 1 1 BAR domain SH3_1 PF00018.28 CCF36533.1 - 2.4e-15 55.9 0.0 4.8e-15 54.9 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 CCF36533.1 - 1.2e-12 47.4 0.0 2.1e-12 46.7 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 CCF36533.1 - 1.7e-09 37.2 0.2 9.2e-09 34.9 0.0 2.2 3 0 0 3 3 3 1 Variant SH3 domain TMPIT PF07851.13 CCF36533.1 - 0.026 13.8 6.5 0.85 8.8 0.0 2.2 1 1 1 2 2 2 0 TMPIT-like protein Sec20 PF03908.13 CCF36533.1 - 0.049 13.6 0.8 4.3 7.3 0.1 2.4 2 0 0 2 2 2 0 Sec20 AAA_15 PF13175.6 CCF36533.1 - 0.29 10.8 5.8 0.39 10.4 5.8 1.2 1 0 0 1 1 1 0 AAA ATPase domain Topoisom_I_N PF02919.15 CCF36533.1 - 1.6 8.2 6.5 0.49 9.9 2.4 2.2 3 0 0 3 3 3 0 Eukaryotic DNA topoisomerase I, DNA binding fragment BRE1 PF08647.11 CCF36533.1 - 5.3 7.2 12.2 19 5.4 0.4 2.6 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase MOSC PF03473.17 CCF36535.1 - 2.1e-17 63.4 0.0 6e-17 61.9 0.0 1.8 1 1 0 1 1 1 1 MOSC domain Fer2 PF00111.27 CCF36535.1 - 2.9e-10 40.0 1.6 6.4e-10 38.8 1.6 1.5 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain 3-alpha PF03475.14 CCF36535.1 - 1.6e-07 31.1 0.0 2.9e-07 30.2 0.0 1.5 1 0 0 1 1 1 1 3-alpha domain NAD_binding_1 PF00175.21 CCF36535.1 - 3.4e-05 24.5 0.7 0.0095 16.6 0.0 3.0 2 1 0 2 2 2 1 Oxidoreductase NAD-binding domain RRP7 PF12923.7 CCF36536.1 - 6.5e-30 103.7 15.7 6.5e-30 103.7 15.7 2.2 3 0 0 3 3 3 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain RRM_Rrp7 PF17799.1 CCF36536.1 - 3.2e-17 62.8 0.0 6.3e-17 61.8 0.0 1.5 1 0 0 1 1 1 1 Rrp7 RRM-like N-terminal domain Usp PF00582.26 CCF36536.1 - 0.015 15.8 4.2 0.037 14.5 0.1 2.4 2 0 0 2 2 2 0 Universal stress protein family VD10_N PF08476.10 CCF36536.1 - 0.15 11.8 0.0 0.28 10.9 0.0 1.4 1 0 0 1 1 1 0 Viral D10 N-terminal PC_rep PF01851.22 CCF36538.1 - 0.44 11.1 8.6 1.3 9.6 0.1 4.7 5 0 0 5 5 5 0 Proteasome/cyclosome repeat eIF3_N PF09440.10 CCF36539.1 - 1.7e-44 151.4 1.2 5.3e-44 149.9 0.4 2.2 2 0 0 2 2 2 1 eIF3 subunit 6 N terminal domain PCI PF01399.27 CCF36539.1 - 1.2e-13 51.5 0.0 3.8e-13 49.9 0.0 1.9 2 0 0 2 2 2 1 PCI domain RPN7 PF10602.9 CCF36539.1 - 0.013 15.2 0.1 0.045 13.5 0.0 1.8 2 0 0 2 2 2 0 26S proteasome subunit RPN7 TPR_14 PF13428.6 CCF36539.1 - 0.3 12.0 2.8 6.3 7.9 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat WSC PF01822.19 CCF36540.1 - 7.2e-25 87.0 22.5 9.1e-19 67.4 13.3 2.1 2 0 0 2 2 2 2 WSC domain DUF2183 PF09949.9 CCF36543.1 - 7.6e-23 80.7 0.1 1.2e-22 80.0 0.1 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2183) Aminotran_1_2 PF00155.21 CCF36544.1 - 1.8e-69 234.7 0.0 2.1e-69 234.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 CCF36544.1 - 0.00043 19.7 0.0 0.00078 18.8 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.20 CCF36544.1 - 0.0018 16.9 0.0 0.0038 15.8 0.0 1.5 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 CCF36544.1 - 0.002 17.5 0.1 0.0054 16.1 0.1 1.6 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 CCF36544.1 - 0.013 14.4 0.0 0.029 13.3 0.0 1.6 1 1 0 1 1 1 0 Aminotransferase class-V Foie-gras_1 PF11817.8 CCF36544.1 - 0.054 13.1 0.1 0.14 11.8 0.0 1.6 2 0 0 2 2 2 0 Foie gras liver health family 1 Myb_DNA-bind_3 PF12776.7 CCF36545.1 - 3.3e-25 88.9 0.6 7.3e-25 87.8 0.6 1.6 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain TFIIA PF03153.13 CCF36545.1 - 0.0095 16.0 17.6 0.014 15.4 17.6 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Lin-8 PF03353.15 CCF36545.1 - 0.25 10.9 5.9 0.39 10.3 5.9 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Suf PF05843.14 CCF36545.1 - 0.44 10.5 8.6 0.61 10.0 8.6 1.4 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Spt20 PF12090.8 CCF36545.1 - 1.7 8.2 22.2 2.6 7.6 22.2 1.3 1 0 0 1 1 1 0 Spt20 family PAT1 PF09770.9 CCF36545.1 - 2.2 6.4 17.4 2.8 6.1 17.4 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Presenilin PF01080.17 CCF36545.1 - 4.7 5.9 4.5 6.1 5.5 4.5 1.2 1 0 0 1 1 1 0 Presenilin Ndc1_Nup PF09531.10 CCF36545.1 - 5.5 5.5 12.1 7.1 5.2 12.1 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF5353 PF17304.2 CCF36547.1 - 1.1e-17 63.5 3.1 1.6e-17 63.0 3.1 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5353) Transport_MerF PF11431.8 CCF36547.1 - 0.1 12.5 0.9 0.1 12.5 0.9 2.1 2 0 0 2 2 2 0 Membrane transport protein MerF HET PF06985.11 CCF36549.1 - 6.1e-11 42.9 4.7 9.4e-09 35.8 0.5 2.4 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) DEAD PF00270.29 CCF36550.1 - 6.1e-26 91.3 0.0 4.1e-25 88.5 0.0 2.2 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF36550.1 - 4.9e-24 84.8 0.0 2.3e-23 82.7 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCF36550.1 - 0.00027 21.0 0.0 0.0006 19.8 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CENP-B_dimeris PF09026.10 CCF36550.1 - 0.045 14.2 5.4 0.11 12.8 5.4 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain NOA36 PF06524.12 CCF36550.1 - 0.37 10.1 5.5 0.93 8.8 5.5 1.6 1 0 0 1 1 1 0 NOA36 protein DNA_pol_phi PF04931.13 CCF36550.1 - 8.8 4.3 13.4 7.5 4.5 10.9 1.9 2 0 0 2 2 2 0 DNA polymerase phi Ank_2 PF12796.7 CCF36551.1 - 3.2e-61 203.9 3.7 2.3e-14 53.7 0.1 6.6 3 1 4 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CCF36551.1 - 7.5e-55 182.6 10.1 3.5e-10 40.2 0.0 11.1 3 2 9 12 12 12 10 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCF36551.1 - 5e-46 149.4 12.6 0.00018 21.6 0.0 13.7 14 0 0 14 14 14 9 Ankyrin repeat Ank_5 PF13857.6 CCF36551.1 - 3.3e-37 126.0 16.2 1.6e-06 28.3 0.1 10.7 6 4 6 12 12 12 9 Ankyrin repeats (many copies) Ank PF00023.30 CCF36551.1 - 3.5e-34 115.7 25.7 7.4e-06 26.2 0.0 13.3 14 0 0 14 14 14 10 Ankyrin repeat Glyco_hydro_61 PF03443.14 CCF36552.1 - 4e-57 193.5 0.1 4.8e-57 193.2 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 DUF1129 PF06570.11 CCF36553.1 - 0.0059 16.1 5.5 0.64 9.5 0.4 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1129) DUF1689 PF07954.11 CCF36553.1 - 0.26 11.7 0.5 0.74 10.2 0.2 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF1689) DUF981 PF06168.11 CCF36553.1 - 0.27 11.1 8.0 1.6 8.7 6.8 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF981) HisKA_7TM PF16927.5 CCF36553.1 - 8.8 6.3 13.8 15 5.6 5.8 2.1 1 1 0 1 1 1 0 N-terminal 7TM region of histidine kinase T4bSS_IcmS PF12608.8 CCF36556.1 - 0.23 11.8 1.8 0.5 10.7 0.8 2.0 2 0 0 2 2 2 0 Type IVb secretion, IcmS, effector-recruitment Nop14 PF04147.12 CCF36556.1 - 4.9 5.2 6.9 6.1 4.9 6.9 1.0 1 0 0 1 1 1 0 Nop14-like family PBP1_TM PF14812.6 CCF36556.1 - 8.2 6.9 7.2 20 5.6 7.2 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Arteri_GP4 PF02497.15 CCF36558.1 - 0.03 14.5 0.6 0.042 14.0 0.6 1.2 1 0 0 1 1 1 0 Arterivirus glycoprotein MGC-24 PF05283.11 CCF36558.1 - 0.075 13.5 6.5 0.1 13.0 6.5 1.2 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin KTI12 PF08433.10 CCF36558.1 - 0.089 12.2 0.8 0.1 12.0 0.8 1.1 1 0 0 1 1 1 0 Chromatin associated protein KTI12 Clathrin PF00637.20 CCF36560.1 - 5.4e-21 75.0 7.5 1.1e-20 74.0 3.1 3.0 2 2 0 2 2 2 1 Region in Clathrin and VPS Vps39_1 PF10366.9 CCF36560.1 - 0.00067 19.9 1.0 0.0019 18.5 0.4 2.1 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 1 SDA1 PF05285.12 CCF36560.1 - 0.0014 18.1 4.6 0.0014 18.1 4.6 2.2 3 0 0 3 3 3 1 SDA1 YL1 PF05764.13 CCF36560.1 - 0.0057 16.8 4.9 0.0057 16.8 4.9 2.2 2 0 0 2 2 2 1 YL1 nuclear protein WD40_like PF17005.5 CCF36560.1 - 0.015 14.6 0.0 0.031 13.6 0.0 1.4 1 0 0 1 1 1 0 WD40-like domain NBP1 PF08537.10 CCF36560.1 - 0.016 14.7 1.0 0.026 13.9 1.0 1.3 1 0 0 1 1 1 0 Fungal Nap binding protein NBP1 zf-RING_5 PF14634.6 CCF36560.1 - 0.021 14.7 2.6 0.052 13.5 2.6 1.7 1 1 0 1 1 1 0 zinc-RING finger domain TPR_7 PF13176.6 CCF36560.1 - 0.039 14.0 0.8 5.6 7.2 0.1 4.0 4 0 0 4 4 3 0 Tetratricopeptide repeat BUD22 PF09073.10 CCF36560.1 - 0.054 12.8 14.8 0.03 13.7 9.3 2.3 2 0 0 2 2 2 0 BUD22 WD40 PF00400.32 CCF36560.1 - 0.064 14.2 0.4 13 6.9 0.1 3.8 3 0 0 3 3 3 0 WD domain, G-beta repeat Pox_Ag35 PF03286.14 CCF36560.1 - 0.14 12.0 8.6 0.87 9.3 7.3 2.3 2 0 0 2 2 2 0 Pox virus Ag35 surface protein PI3K_p85B PF02192.16 CCF36560.1 - 0.2 11.4 0.7 0.45 10.3 0.7 1.5 1 0 0 1 1 1 0 PI3-kinase family, p85-binding domain Mpp10 PF04006.12 CCF36560.1 - 0.2 10.1 10.2 0.41 9.0 10.2 1.4 1 0 0 1 1 1 0 Mpp10 protein zf-RING_2 PF13639.6 CCF36560.1 - 0.55 10.6 2.7 0.99 9.8 0.5 2.2 2 0 0 2 2 2 0 Ring finger domain SpoIIIAH PF12685.7 CCF36560.1 - 0.61 9.9 4.6 0.51 10.1 2.2 2.0 2 0 0 2 2 2 0 SpoIIIAH-like protein zf-RING_UBOX PF13445.6 CCF36560.1 - 0.8 9.8 3.9 0.2 11.7 0.3 1.9 2 0 0 2 2 2 0 RING-type zinc-finger zf-RING_11 PF17123.5 CCF36560.1 - 1.3 8.9 4.1 2.5 7.9 4.1 1.5 1 0 0 1 1 1 0 RING-like zinc finger Cwf_Cwc_15 PF04889.12 CCF36560.1 - 1.8 8.3 25.4 1.3 8.8 19.9 2.4 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein RXT2_N PF08595.11 CCF36560.1 - 4.4 7.3 16.4 0.093 12.8 8.2 2.1 2 0 0 2 2 2 0 RXT2-like, N-terminal DNA_pol_phi PF04931.13 CCF36560.1 - 6.2 4.8 28.5 0.18 9.9 21.2 1.9 2 0 0 2 2 2 0 DNA polymerase phi ANAPC1 PF12859.7 CCF36561.1 - 2.3e-42 144.6 1.0 2.3e-42 144.6 1.0 2.2 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 1 zf-CCHC PF00098.23 CCF36563.1 - 3.9e-45 150.0 63.9 6.3e-09 35.5 1.9 7.2 7 0 0 7 7 7 7 Zinc knuckle zf-CCHC_2 PF13696.6 CCF36563.1 - 1.6e-11 43.8 52.0 0.0014 18.4 1.2 7.4 7 0 0 7 7 7 6 Zinc knuckle zf-CCHC_3 PF13917.6 CCF36563.1 - 2e-11 43.7 42.3 0.0038 17.1 1.0 7.3 1 1 6 7 7 7 6 Zinc knuckle zf-CCHC_4 PF14392.6 CCF36563.1 - 3.6e-11 42.6 41.0 0.019 14.7 0.3 7.1 7 0 0 7 7 7 6 Zinc knuckle zf-CCHC_6 PF15288.6 CCF36563.1 - 1.4e-10 40.8 48.9 0.00076 19.3 0.9 7.3 4 1 3 7 7 7 6 Zinc knuckle Hydrolase_6 PF13344.6 CCF36564.1 - 3.1e-23 81.8 0.0 6.8e-23 80.7 0.0 1.6 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CCF36564.1 - 6e-14 51.9 0.0 2.5e-13 49.9 0.0 2.1 2 0 0 2 2 2 1 HAD-hyrolase-like Hydrolase PF00702.26 CCF36564.1 - 0.0079 16.5 0.0 6.5 7.0 0.0 2.7 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase Sec23_trunk PF04811.15 CCF36565.1 - 1.5e-50 172.1 0.0 2.3e-50 171.4 0.0 1.3 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 CCF36565.1 - 1.5e-26 92.2 0.1 1.4e-25 89.1 0.0 2.5 2 1 0 2 2 2 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 CCF36565.1 - 3.7e-18 66.0 0.0 9e-18 64.8 0.0 1.7 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Gelsolin PF00626.22 CCF36565.1 - 3.8e-10 39.5 0.0 8.8e-10 38.4 0.0 1.7 1 0 0 1 1 1 1 Gelsolin repeat Ribosomal_L36 PF00444.18 CCF36566.1 - 3.4e-21 75.1 10.3 5e-21 74.6 10.3 1.3 1 0 0 1 1 1 1 Ribosomal protein L36 Rimk_N PF18030.1 CCF36566.1 - 0.0032 17.8 0.3 1.7 9.0 0.1 2.2 1 1 1 2 2 2 2 RimK PreATP-grasp domain Ribosomal_L35p PF01632.19 CCF36566.1 - 0.65 10.5 7.7 0.44 11.1 5.3 2.0 2 1 0 2 2 2 0 Ribosomal protein L35 Peptidase_S8 PF00082.22 CCF36568.1 - 1.6e-15 57.2 0.0 2e-15 56.8 0.0 1.1 1 0 0 1 1 1 1 Subtilase family Lar_N PF09861.9 CCF36568.1 - 0.15 11.2 0.0 0.24 10.5 0.0 1.2 1 0 0 1 1 1 0 Lactate racemase N-terminal domain TPR_4 PF07721.14 CCF36568.1 - 0.23 12.2 1.0 18 6.3 0.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF983 PF06170.12 CCF36569.1 - 0.026 14.9 0.0 0.045 14.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF983) PAPS_reduct PF01507.19 CCF36570.1 - 2.2e-43 148.3 0.4 5.5e-43 147.0 0.0 1.7 2 0 0 2 2 2 1 Phosphoadenosine phosphosulfate reductase family Tox-REase-5 PF15648.6 CCF36570.1 - 0.089 13.3 0.1 0.24 11.9 0.1 1.7 1 0 0 1 1 1 0 Restriction endonuclease fold toxin 5 TYW3 PF02676.14 CCF36571.1 - 8.5e-74 247.5 0.0 1.2e-73 247.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase TYW3 DUF1690 PF07956.11 CCF36572.1 - 1.1e-15 58.2 0.3 1.2e-15 58.1 0.3 1.1 1 0 0 1 1 1 1 Protein of Unknown function (DUF1690) CHCH PF06747.13 CCF36572.1 - 0.12 12.5 0.0 0.16 12.1 0.0 1.1 1 0 0 1 1 1 0 CHCH domain Carb_anhydrase PF00194.21 CCF36573.1 - 4.9e-23 82.0 0.0 8.7e-23 81.1 0.0 1.4 1 1 0 1 1 1 1 Eukaryotic-type carbonic anhydrase TcpF PF06340.11 CCF36574.1 - 0.058 12.3 0.0 0.076 11.9 0.0 1.2 1 0 0 1 1 1 0 Vibrio cholerae toxin co-regulated pilus biosynthesis protein F Dehydratase_hem PF13816.6 CCF36575.1 - 6.9e-23 81.5 0.0 7.3e-23 81.4 0.0 1.0 1 0 0 1 1 1 1 Haem-containing dehydratase DUF4188 PF13826.6 CCF36575.1 - 0.0012 19.2 0.0 0.0013 19.0 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4188) PNP_UDP_1 PF01048.20 CCF36576.1 - 9.1e-06 25.1 0.2 9.7e-06 25.0 0.2 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily BET PF17035.5 CCF36577.1 - 0.12 12.6 2.1 0.31 11.2 0.7 2.1 2 0 0 2 2 2 0 Bromodomain extra-terminal - transcription regulation Bac_rhamnosid6H PF17389.2 CCF36580.1 - 7.3e-12 45.2 0.0 4.7e-11 42.5 0.0 1.9 2 0 0 2 2 2 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain HA2 PF04408.23 CCF36581.1 - 3.5e-17 62.6 0.2 8.5e-16 58.2 0.0 2.6 2 0 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.31 CCF36581.1 - 1.7e-16 60.5 0.0 4.3e-16 59.2 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 CCF36581.1 - 1e-15 57.8 0.0 2.1e-15 56.8 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 CCF36581.1 - 3.3e-11 43.3 0.1 7e-11 42.2 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 CCF36581.1 - 0.00024 21.2 0.0 0.00053 20.0 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit RWD PF05773.22 CCF36581.1 - 0.00034 20.9 0.1 0.00067 19.9 0.1 1.5 1 0 0 1 1 1 1 RWD domain dsRBD2 PF17842.1 CCF36581.1 - 0.0069 16.6 0.0 0.019 15.2 0.0 1.6 1 0 0 1 1 1 1 Double-stranded RNA binding domain 2 IHABP4_N PF16174.5 CCF36581.1 - 0.013 16.1 3.9 0.013 16.1 3.9 2.5 2 0 0 2 2 2 0 Intracellular hyaluronan-binding protein 4 N-terminal ATPase PF06745.13 CCF36581.1 - 0.014 14.7 0.4 0.036 13.4 0.0 1.8 2 0 0 2 2 2 0 KaiC DND1_DSRM PF14709.7 CCF36581.1 - 0.015 15.5 0.1 0.048 13.9 0.1 1.8 1 0 0 1 1 1 0 double strand RNA binding domain from DEAD END PROTEIN 1 AAA_29 PF13555.6 CCF36581.1 - 0.028 14.2 0.0 0.063 13.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.6 CCF36581.1 - 0.038 14.3 2.3 0.96 9.7 1.8 3.2 3 1 0 3 3 2 0 AAA domain T2SSE PF00437.20 CCF36581.1 - 0.048 12.7 0.0 0.16 11.0 0.0 1.8 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_23 PF13476.6 CCF36581.1 - 0.074 13.5 1.5 0.23 12.0 0.1 2.4 2 0 0 2 2 2 0 AAA domain InPase PF18823.1 CCF36581.1 - 0.2 11.3 2.4 0.41 10.3 2.4 1.4 1 0 0 1 1 1 0 Inorganic Pyrophosphatase zf-C2HE PF16278.5 CCF36582.1 - 1.9e-17 63.5 0.0 4.5e-17 62.2 0.0 1.7 1 0 0 1 1 1 1 C2HE / C2H2 / C2HC zinc-binding finger HIT PF01230.23 CCF36582.1 - 1.5e-16 60.9 0.1 2.6e-16 60.1 0.1 1.4 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 CCF36582.1 - 2.2e-15 57.1 7.5 2.3e-14 53.8 7.5 2.1 1 1 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding TRAP_alpha PF03896.16 CCF36584.1 - 2.5e-09 36.7 0.0 4e-09 36.1 0.0 1.4 1 1 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit Cyclin_N PF00134.23 CCF36585.1 - 9.3e-44 148.2 0.2 2.1e-43 147.1 0.2 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 CCF36585.1 - 4.7e-36 123.5 0.1 1.3e-35 122.0 0.0 1.8 2 0 0 2 2 2 1 Cyclin, C-terminal domain DUF2383 PF09537.10 CCF36585.1 - 0.12 12.7 0.1 0.37 11.1 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF2383) FAD_binding_4 PF01565.23 CCF36587.1 - 3.6e-23 81.9 1.0 5.7e-23 81.2 1.0 1.3 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 CCF36587.1 - 5.1e-10 39.3 0.5 1.3e-09 38.0 0.5 1.7 1 0 0 1 1 1 1 Berberine and berberine like Cytokin-bind PF09265.10 CCF36587.1 - 0.2 11.0 0.0 0.32 10.4 0.0 1.2 1 0 0 1 1 1 0 Cytokinin dehydrogenase 1, FAD and cytokinin binding Glyoxalase PF00903.25 CCF36588.1 - 6.4e-13 49.0 0.1 1.3e-12 48.1 0.0 1.5 2 0 0 2 2 2 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 CCF36588.1 - 0.0076 17.0 0.0 0.032 15.0 0.0 1.9 2 0 0 2 2 2 1 Glyoxalase-like domain Glyoxalase_2 PF12681.7 CCF36588.1 - 0.013 15.4 0.0 0.019 14.9 0.0 1.2 1 0 0 1 1 1 0 Glyoxalase-like domain NinF PF05810.12 CCF36588.1 - 0.061 13.2 0.1 0.15 12.0 0.0 1.7 2 0 0 2 2 2 0 NinF protein Peptidase_C48 PF02902.19 CCF36588.1 - 0.062 13.1 0.0 0.082 12.7 0.0 1.2 1 0 0 1 1 1 0 Ulp1 protease family, C-terminal catalytic domain Fungal_trans PF04082.18 CCF36589.1 - 3.4e-22 78.7 0.0 5.3e-22 78.1 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF36589.1 - 4.2e-08 33.2 15.2 6.6e-08 32.5 15.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pox_Ag35 PF03286.14 CCF36589.1 - 0.3 10.9 5.1 0.95 9.2 5.1 1.8 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Clusterin PF01093.17 CCF36589.1 - 0.38 9.7 3.8 0.64 9.0 3.8 1.3 1 0 0 1 1 1 0 Clusterin Acetyltransf_3 PF13302.7 CCF36591.1 - 1.1e-35 123.3 0.0 1.4e-35 123.0 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CCF36591.1 - 0.034 14.4 0.0 0.53 10.5 0.0 2.1 1 1 0 1 1 1 0 Acetyltransferase (GNAT) family FR47 PF08445.10 CCF36591.1 - 0.1 12.6 0.0 6.1 6.9 0.0 2.3 2 0 0 2 2 2 0 FR47-like protein Adeno_E1A PF02703.14 CCF36591.1 - 0.15 11.6 0.2 0.18 11.3 0.2 1.2 1 0 0 1 1 1 0 Early E1A protein Cse1 PF08506.10 CCF36592.1 - 5.4e-81 272.3 1.6 6.6e-81 272.0 1.6 1.1 1 0 0 1 1 1 1 Cse1 IBN_N PF03810.19 CCF36592.1 - 7.4e-14 51.4 0.0 2.4e-13 49.8 0.0 1.9 1 0 0 1 1 1 1 Importin-beta N-terminal domain Fanconi_C PF02106.15 CCF36592.1 - 0.014 14.2 0.3 0.02 13.6 0.3 1.1 1 0 0 1 1 1 0 Fanconi anaemia group C protein Xpo1 PF08389.12 CCF36592.1 - 0.04 14.0 0.8 0.15 12.1 0.8 2.0 1 1 0 1 1 1 0 Exportin 1-like protein DUF3384 PF11864.8 CCF36593.1 - 1.5e-138 462.7 0.0 2e-138 462.3 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3384) MFS_1 PF07690.16 CCF36594.1 - 2.6e-31 108.9 26.9 1.5e-28 99.8 15.1 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF36594.1 - 4.5e-14 52.2 9.2 1.1e-13 50.9 0.0 2.4 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_3 PF05977.13 CCF36594.1 - 0.0088 14.5 8.9 0.22 9.9 4.8 2.2 2 0 0 2 2 2 2 Transmembrane secretion effector TetR_C_14 PF17754.1 CCF36594.1 - 0.095 12.6 0.0 1.6 8.7 0.0 2.5 2 0 0 2 2 2 0 MftR C-terminal domain GP4 PF03010.14 CCF36597.1 - 0.072 13.0 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 GP4 TFIIF_alpha PF05793.12 CCF36598.1 - 4.8 5.7 42.5 7.2 5.1 42.5 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) VPS28 PF03997.12 CCF36599.1 - 2e-68 229.8 0.2 2.3e-68 229.6 0.2 1.0 1 0 0 1 1 1 1 VPS28 protein MMM1 PF10296.9 CCF36600.1 - 6.6e-06 25.4 0.0 1.4e-05 24.3 0.0 1.5 2 0 0 2 2 2 1 Maintenance of mitochondrial morphology protein 1 PIP5K PF01504.18 CCF36601.1 - 1.8e-33 116.0 0.0 4.7e-24 85.1 0.0 2.2 1 1 1 2 2 2 2 Phosphatidylinositol-4-phosphate 5-Kinase baeRF_family5 PF18846.1 CCF36601.1 - 0.035 14.3 0.0 0.067 13.4 0.0 1.3 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 5 Methyltransf_PK PF05891.12 CCF36602.1 - 6.7e-13 48.7 0.1 7.1e-13 48.6 0.1 1.0 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_PK PF05891.12 CCF36603.1 - 1.6e-65 220.7 0.0 1.7e-65 220.6 0.0 1.0 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_25 PF13649.6 CCF36603.1 - 0.00032 21.4 0.0 0.0005 20.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF36603.1 - 0.00055 20.5 0.0 0.00077 20.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain NIF PF03031.18 CCF36606.1 - 2.9e-54 183.1 0.5 3.9e-54 182.7 0.5 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase DUF3586 PF12131.8 CCF36607.1 - 0.15 12.3 2.8 0.79 10.0 0.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3586) AMP-binding PF00501.28 CCF36608.1 - 6.2e-70 235.9 0.1 5.4e-50 170.2 0.0 2.3 1 1 1 2 2 2 2 AMP-binding enzyme Condensation PF00668.20 CCF36608.1 - 2.2e-31 109.0 0.0 8.2e-30 103.9 0.0 2.3 1 1 0 1 1 1 1 Condensation domain PP-binding PF00550.25 CCF36608.1 - 1.1e-11 44.8 0.1 3.8e-11 43.2 0.0 2.0 2 0 0 2 2 2 1 Phosphopantetheine attachment site AMP-binding_C PF13193.6 CCF36608.1 - 5.7e-07 30.4 0.0 3.7e-06 27.8 0.0 2.6 1 1 0 1 1 1 1 AMP-binding enzyme C-terminal domain NOB1_Zn_bind PF08772.11 CCF36608.1 - 0.14 12.3 0.4 4.4 7.5 0.2 2.4 2 0 0 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like adh_short_C2 PF13561.6 CCF36609.1 - 5.7e-63 212.6 0.3 8.9e-63 212.0 0.3 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF36609.1 - 5.2e-51 172.9 0.4 7.7e-51 172.3 0.4 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF36609.1 - 2.1e-10 40.8 0.1 2.9e-10 40.3 0.1 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF36609.1 - 0.00031 20.3 0.1 0.0007 19.1 0.1 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family PA PF02225.22 CCF36609.1 - 0.0031 17.5 0.1 0.011 15.7 0.0 1.9 2 0 0 2 2 2 1 PA domain GDP_Man_Dehyd PF16363.5 CCF36609.1 - 0.023 14.1 0.1 0.037 13.4 0.1 1.4 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 CCF36609.1 - 0.035 13.3 0.0 0.052 12.7 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein TFIIB PF00382.19 CCF36610.1 - 3.1e-05 23.9 0.0 0.088 12.9 0.0 2.5 2 0 0 2 2 2 2 Transcription factor TFIIB repeat Cyclin_N PF00134.23 CCF36610.1 - 0.00099 18.8 0.0 0.04 13.7 0.0 2.3 2 0 0 2 2 2 1 Cyclin, N-terminal domain DUF2737 PF10930.8 CCF36610.1 - 0.054 13.1 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2737) Vps5 PF09325.10 CCF36611.1 - 3e-11 43.3 1.6 5e-11 42.6 1.6 1.2 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.24 CCF36611.1 - 1e-10 41.6 0.0 2.9e-10 40.1 0.0 1.8 1 0 0 1 1 1 1 PX domain NST1 PF13945.6 CCF36611.1 - 0.04 14.0 1.2 0.082 13.0 1.2 1.4 1 0 0 1 1 1 0 Salt tolerance down-regulator Cullin PF00888.22 CCF36612.1 - 9.8e-23 80.6 0.0 1.9e-22 79.6 0.0 1.4 1 0 0 1 1 1 1 Cullin family ANAPC2 PF08672.11 CCF36612.1 - 7.6e-22 77.6 0.4 4.1e-21 75.2 0.1 2.5 3 0 0 3 3 3 1 Anaphase promoting complex (APC) subunit 2 TPR_16 PF13432.6 CCF36614.1 - 6.7e-09 36.3 19.6 0.012 16.2 0.1 7.6 6 2 1 7 7 6 4 Tetratricopeptide repeat TPR_19 PF14559.6 CCF36614.1 - 2e-08 34.6 17.3 0.067 13.7 0.0 6.9 5 2 2 7 7 7 3 Tetratricopeptide repeat TPR_1 PF00515.28 CCF36614.1 - 5.4e-08 32.3 6.7 0.072 12.9 0.0 8.0 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_11 PF13414.6 CCF36614.1 - 1.2e-06 28.0 0.1 0.036 13.8 0.0 5.2 7 0 0 7 7 7 2 TPR repeat TPR_17 PF13431.6 CCF36614.1 - 4.8e-06 26.6 0.2 0.064 13.7 0.0 6.0 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_2 PF07719.17 CCF36614.1 - 1.9e-05 24.4 17.0 0.91 9.8 0.0 8.1 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_12 PF13424.6 CCF36614.1 - 0.00069 19.9 18.8 0.039 14.3 0.7 6.4 7 1 1 8 8 8 3 Tetratricopeptide repeat TPR_8 PF13181.6 CCF36614.1 - 0.00073 19.5 8.7 4.4 7.8 0.0 7.4 9 0 0 9 9 9 1 Tetratricopeptide repeat TPR_20 PF14561.6 CCF36614.1 - 0.0015 18.8 7.3 1.4 9.3 0.1 5.0 6 0 0 6 6 5 2 Tetratricopeptide repeat ANAPC3 PF12895.7 CCF36614.1 - 0.0019 18.4 13.1 0.016 15.4 1.7 5.4 6 0 0 6 6 6 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 CCF36614.1 - 0.011 15.9 7.8 0.061 13.5 0.2 4.7 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.6 CCF36614.1 - 0.024 15.4 28.5 12 7.0 0.1 9.1 7 2 4 11 11 10 0 Tetratricopeptide repeat Abhydrolase_3 PF07859.13 CCF36616.1 - 9.3e-37 126.9 0.0 1.1e-36 126.7 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 CCF36616.1 - 0.0022 16.9 1.2 0.11 11.3 0.0 2.0 2 0 0 2 2 2 2 Carboxylesterase family DNA_binding_1 PF01035.20 CCF36617.1 - 1.7e-19 69.7 0.7 5.7e-19 68.0 0.7 1.7 1 1 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain HMG_box PF00505.19 CCF36618.1 - 7.8e-22 77.5 0.7 1.4e-21 76.7 0.7 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 CCF36618.1 - 7.4e-07 29.7 1.5 8.4e-07 29.5 0.2 1.8 2 0 0 2 2 2 1 HMG-box domain Coatomer_WDAD PF04053.14 CCF36619.1 - 2.5e-174 580.5 0.0 8.7e-174 578.7 0.0 1.8 2 0 0 2 2 2 1 Coatomer WD associated region WD40 PF00400.32 CCF36619.1 - 2.8e-39 132.4 7.3 4.4e-06 27.3 0.0 9.0 9 0 0 9 9 9 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF36619.1 - 9e-08 32.3 0.0 4 7.8 0.0 6.0 4 2 1 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CCF36619.1 - 4.3e-05 22.4 2.2 0.036 12.7 0.1 3.9 2 2 1 3 3 3 3 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 CCF36619.1 - 0.0043 17.1 0.0 1.1 9.4 0.0 3.6 2 2 1 3 3 3 1 Ciliary BBSome complex subunit 2, middle region Mannitol_dh_C PF08125.13 CCF36620.1 - 2.6e-10 40.2 0.0 3e-10 40.0 0.0 1.1 1 0 0 1 1 1 1 Mannitol dehydrogenase C-terminal domain FRG1 PF06229.12 CCF36621.1 - 7.3e-48 162.8 0.1 1.3e-47 162.0 0.1 1.3 1 0 0 1 1 1 1 FRG1-like domain Fascin PF06268.13 CCF36621.1 - 0.0044 17.2 0.0 0.015 15.5 0.0 1.9 2 0 0 2 2 2 1 Fascin domain 2OG-FeII_Oxy PF03171.20 CCF36622.1 - 0.00063 20.2 0.0 0.0033 17.9 0.0 2.0 1 1 1 2 2 2 1 2OG-Fe(II) oxygenase superfamily Thioredoxin_4 PF13462.6 CCF36623.1 - 3.8e-06 27.2 0.0 1.2e-05 25.5 0.0 1.8 1 1 0 1 1 1 1 Thioredoxin HTH_AsnC-type PF13404.6 CCF36623.1 - 0.045 13.6 0.1 0.11 12.4 0.0 1.6 2 0 0 2 2 2 0 AsnC-type helix-turn-helix domain DSBA PF01323.20 CCF36623.1 - 0.21 11.4 1.7 6.5 6.5 0.3 2.4 1 1 1 2 2 2 0 DSBA-like thioredoxin domain Glyco_hydro_17 PF00332.18 CCF36625.1 - 4.5e-06 26.5 0.7 1.8e-05 24.5 0.3 2.0 1 1 1 2 2 2 1 Glycosyl hydrolases family 17 Cyt-b5 PF00173.28 CCF36626.1 - 1.7e-10 40.9 0.0 3.2e-10 40.0 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain FA_desaturase PF00487.24 CCF36626.1 - 6.8e-07 29.4 22.6 6.8e-07 29.4 22.6 1.5 1 1 0 1 1 1 1 Fatty acid desaturase Ribosomal_S27e PF01667.17 CCF36626.1 - 0.066 12.9 0.0 1.2 8.9 0.0 2.2 2 0 0 2 2 2 0 Ribosomal protein S27 Tubulin PF00091.25 CCF36627.1 - 2.9e-67 226.7 0.0 4.4e-67 226.1 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 CCF36627.1 - 1.5e-34 118.9 0.4 3.1e-34 117.9 0.1 1.6 2 0 0 2 2 2 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 CCF36627.1 - 1.6e-07 31.6 0.0 3.4e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain PRK PF00485.18 CCF36631.1 - 1.1e-05 25.2 0.2 4.7e-05 23.2 0.2 1.8 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family T2SSE PF00437.20 CCF36631.1 - 0.00015 20.9 0.0 0.015 14.4 0.0 2.2 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_18 PF13238.6 CCF36631.1 - 0.00042 20.9 0.1 0.0023 18.5 0.1 2.1 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CCF36631.1 - 0.00049 20.5 0.0 0.00069 20.0 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.22 CCF36631.1 - 0.0012 18.0 0.0 0.0017 17.6 0.0 1.2 1 0 0 1 1 1 1 NB-ARC domain Zeta_toxin PF06414.12 CCF36631.1 - 0.0025 17.1 0.1 0.0071 15.6 0.0 1.7 2 0 0 2 2 2 1 Zeta toxin MeaB PF03308.16 CCF36631.1 - 0.0034 16.4 0.0 0.0053 15.8 0.0 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Thymidylate_kin PF02223.17 CCF36631.1 - 0.007 16.1 0.0 0.19 11.4 0.0 2.1 2 0 0 2 2 2 1 Thymidylate kinase AAA_33 PF13671.6 CCF36631.1 - 0.012 15.7 0.1 0.11 12.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 CCF36631.1 - 0.013 15.8 0.0 0.02 15.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.6 CCF36631.1 - 0.048 14.1 0.1 0.41 11.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain RuvB_N PF05496.12 CCF36631.1 - 0.12 12.1 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain NTPase_1 PF03266.15 CCF36631.1 - 0.14 12.1 0.1 0.21 11.5 0.1 1.3 1 0 0 1 1 1 0 NTPase cobW PF02492.19 CCF36631.1 - 0.14 11.8 0.3 0.21 11.1 0.3 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA PF00004.29 CCF36631.1 - 0.16 12.4 0.0 0.26 11.7 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Viral_helicase1 PF01443.18 CCF36631.1 - 0.19 11.4 0.0 0.26 11.0 0.0 1.2 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase CoaE PF01121.20 CCF36631.1 - 0.21 11.3 0.8 7.6 6.2 0.1 2.4 3 0 0 3 3 3 0 Dephospho-CoA kinase COPI_C PF06957.11 CCF36632.1 - 0.084 11.6 0.2 0.15 10.8 0.0 1.5 1 1 1 2 2 2 0 Coatomer (COPI) alpha subunit C-terminus PRELI PF04707.14 CCF36633.1 - 3.4e-39 134.2 0.0 4.2e-39 133.9 0.0 1.1 1 0 0 1 1 1 1 PRELI-like family Peptidase_M24 PF00557.24 CCF36634.1 - 1.4e-45 155.5 0.1 1.8e-45 155.2 0.1 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 PHD PF00628.29 CCF36635.1 - 3.8e-05 23.5 7.8 6.7e-05 22.7 7.8 1.4 1 0 0 1 1 1 1 PHD-finger ING PF12998.7 CCF36635.1 - 0.027 15.1 0.0 0.077 13.6 0.0 1.9 1 1 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding RXT2_N PF08595.11 CCF36635.1 - 1.9 8.5 9.0 0.26 11.3 1.1 3.1 3 0 0 3 3 3 0 RXT2-like, N-terminal Pneumo_M2 PF07380.11 CCF36636.1 - 0.0018 18.5 0.0 0.0025 18.1 0.0 1.3 1 0 0 1 1 1 1 Pneumovirus M2 protein XPG_I PF00867.18 CCF36637.1 - 3e-14 53.1 0.4 6.5e-14 52.1 0.4 1.6 1 0 0 1 1 1 1 XPG I-region MFS_1 PF07690.16 CCF36638.1 - 2.7e-34 118.6 20.7 2.7e-34 118.6 20.7 1.5 1 1 1 2 2 2 1 Major Facilitator Superfamily bZIP_1 PF00170.21 CCF36639.1 - 8.5e-11 41.8 4.6 1.3e-10 41.2 4.6 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 CCF36639.1 - 3.1e-06 27.2 2.0 6.1e-06 26.2 2.0 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 CCF36639.1 - 0.0012 19.3 3.3 0.0031 18.0 3.3 1.7 1 0 0 1 1 1 1 bZIP Maf transcription factor YlqD PF11068.8 CCF36639.1 - 0.11 12.9 1.8 0.19 12.1 1.8 1.4 1 0 0 1 1 1 0 YlqD protein DUF4407 PF14362.6 CCF36639.1 - 0.43 9.9 1.7 0.57 9.5 1.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Fungal_trans PF04082.18 CCF36640.1 - 1.4e-15 57.1 0.1 2.8e-15 56.1 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain p450 PF00067.22 CCF36641.1 - 3.5e-66 223.8 0.0 7.5e-64 216.2 0.0 2.0 1 1 0 1 1 1 1 Cytochrome P450 NAD-GH PF10712.9 CCF36642.1 - 1.1e-13 50.6 0.8 1.3e-13 50.3 0.8 1.1 1 0 0 1 1 1 1 NAD-specific glutamate dehydrogenase Autophagy_N PF03986.13 CCF36643.1 - 2.2e-46 157.2 0.5 3.8e-46 156.4 0.0 1.6 2 0 0 2 2 2 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_C PF10381.9 CCF36643.1 - 5.3e-16 57.8 0.6 9.8e-16 57.0 0.6 1.5 1 0 0 1 1 1 1 Autophagocytosis associated protein C-terminal Autophagy_act_C PF03987.15 CCF36643.1 - 8.2e-16 58.3 0.2 1.9e-15 57.2 0.2 1.6 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain TRP PF06011.12 CCF36645.1 - 1.2e-44 152.8 6.0 1.5e-44 152.4 6.0 1.2 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 CCF36645.1 - 6.7e-44 149.6 0.8 9.2e-44 149.2 0.8 1.2 1 0 0 1 1 1 1 ML-like domain E1_DerP2_DerF2 PF02221.15 CCF36645.1 - 0.00045 20.6 0.2 0.0008 19.8 0.1 1.5 2 0 0 2 2 2 1 ML domain CclA_1 PF16942.5 CCF36645.1 - 0.16 12.3 6.5 2.3 8.5 0.2 3.0 3 0 0 3 3 3 0 Putative cyclic bacteriocin Peroxidase_2 PF01328.17 CCF36647.1 - 9.5e-26 91.5 0.1 9e-25 88.3 0.0 2.1 2 0 0 2 2 2 1 Peroxidase, family 2 Cyclase PF04199.13 CCF36648.1 - 1.1e-08 35.4 0.0 1.4e-08 35.0 0.0 1.2 1 0 0 1 1 1 1 Putative cyclase MFS_1 PF07690.16 CCF36649.1 - 5.2e-38 130.9 55.6 1.2e-34 119.8 29.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Lipocalin_5 PF13924.6 CCF36650.1 - 2.5e-07 30.6 0.0 2.8e-07 30.4 0.0 1.1 1 0 0 1 1 1 1 Lipocalin-like domain HPP PF04982.13 CCF36653.1 - 0.0037 17.4 1.0 0.0087 16.2 1.0 1.6 1 0 0 1 1 1 1 HPP family LRR_8 PF13855.6 CCF36654.1 - 7.8e-13 48.0 6.8 6.4e-08 32.2 3.0 3.3 1 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 CCF36654.1 - 8.7e-13 48.3 3.8 0.00046 20.5 0.8 3.6 3 0 0 3 3 3 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 CCF36654.1 - 1.1e-05 25.3 4.1 22 6.1 0.2 5.7 5 1 0 5 5 5 2 Leucine Rich Repeat LRR_9 PF14580.6 CCF36654.1 - 0.0033 16.9 0.5 0.011 15.2 0.3 1.8 1 1 1 2 2 2 2 Leucine-rich repeat LRR_6 PF13516.6 CCF36654.1 - 0.04 14.0 11.4 14 6.1 0.0 5.1 5 0 0 5 5 5 0 Leucine Rich repeat Nuc_sug_transp PF04142.15 CCF36655.1 - 4.7e-104 347.9 7.2 7e-104 347.4 7.2 1.2 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 CCF36655.1 - 1.4e-07 31.8 26.3 0.00047 20.3 4.4 2.5 2 0 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 CCF36655.1 - 4.1e-07 29.5 5.8 0.00018 20.8 2.0 2.3 2 0 0 2 2 2 2 UAA transporter family TPT PF03151.16 CCF36655.1 - 6.8e-05 22.3 13.7 0.0029 17.0 5.4 2.3 2 0 0 2 2 2 2 Triose-phosphate Transporter family Il13Ra_Ig PF18001.1 CCF36655.1 - 0.14 12.2 0.0 0.29 11.3 0.0 1.4 1 0 0 1 1 1 0 Interleukin-13 receptor subunit alpha Ig-like domain DUF2306 PF10067.9 CCF36655.1 - 0.15 12.3 4.4 0.39 10.9 4.4 1.7 1 0 0 1 1 1 0 Predicted membrane protein (DUF2306) DMT_6 PF04342.12 CCF36655.1 - 1.4 9.2 8.0 11 6.3 1.2 2.7 3 0 0 3 3 3 0 Putative member of DMT superfamily (DUF486) TMEM234 PF10639.9 CCF36655.1 - 6.1 6.9 9.0 4.8 7.2 1.2 2.3 2 0 0 2 2 2 0 Putative transmembrane family 234 Sec63 PF02889.16 CCF36656.1 - 3.4e-09 36.3 0.0 4.6e-09 35.8 0.0 1.1 1 0 0 1 1 1 1 Sec63 Brl domain HHH_5 PF14520.6 CCF36656.1 - 6e-06 26.8 0.0 1.5e-05 25.5 0.0 1.7 2 0 0 2 2 2 1 Helix-hairpin-helix domain HHH PF00633.23 CCF36656.1 - 0.00039 20.1 0.6 0.0008 19.2 0.1 1.8 2 0 0 2 2 2 1 Helix-hairpin-helix motif DUF4332 PF14229.6 CCF36656.1 - 0.0058 16.9 0.0 0.016 15.4 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4332) Helo_like_N PF17111.5 CCF36657.1 - 3.1e-07 30.0 0.0 3.6e-07 29.8 0.0 1.0 1 0 0 1 1 1 1 Fungal N-terminal domain of STAND proteins SesA PF17107.5 CCF36657.1 - 4.2e-06 26.9 0.0 5.1e-06 26.7 0.0 1.1 1 0 0 1 1 1 1 N-terminal domain on NACHT_NTPase and P-loop NTPases Syntaxin_2 PF14523.6 CCF36657.1 - 0.0016 18.7 0.0 0.0027 18.0 0.0 1.3 1 1 0 1 1 1 1 Syntaxin-like protein Syntaxin-6_N PF09177.11 CCF36657.1 - 0.02 15.4 0.0 0.033 14.7 0.0 1.4 1 1 0 1 1 1 0 Syntaxin 6, N-terminal DUF2383 PF09537.10 CCF36657.1 - 0.11 12.9 0.1 0.25 11.7 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF2383) Hce2 PF14856.6 CCF36658.1 - 5e-16 58.9 0.4 4.7e-10 39.7 0.0 2.2 2 0 0 2 2 2 2 Pathogen effector; putative necrosis-inducing factor AAA_12 PF13087.6 CCF36659.1 - 4.9e-41 140.5 0.0 8.5e-41 139.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 CCF36659.1 - 8.2e-30 104.5 0.1 1.3e-29 103.9 0.1 1.3 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CCF36659.1 - 5.8e-12 45.7 0.0 5.4e-06 26.2 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 CCF36659.1 - 1.9e-08 34.8 0.0 8.8e-08 32.6 0.0 2.1 1 1 0 1 1 1 1 AAA domain Helicase_RecD PF05127.14 CCF36659.1 - 0.0011 18.9 0.1 0.2 11.5 0.0 2.5 2 0 0 2 2 2 1 Helicase DUF2075 PF09848.9 CCF36659.1 - 0.0037 16.6 0.3 0.019 14.2 0.0 2.3 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) AAA_5 PF07728.14 CCF36659.1 - 0.0086 16.1 0.1 0.88 9.6 0.0 2.7 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) Viral_helicase1 PF01443.18 CCF36659.1 - 0.0098 15.7 0.0 6.7 6.4 0.0 2.9 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase DREPP PF05558.12 CCF36659.1 - 0.03 14.2 2.0 0.58 10.0 2.1 2.2 2 0 0 2 2 2 0 DREPP plasma membrane polypeptide ResIII PF04851.15 CCF36659.1 - 0.03 14.3 0.0 0.1 12.6 0.0 1.8 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_16 PF13191.6 CCF36659.1 - 0.03 14.7 0.0 0.15 12.5 0.0 2.2 1 0 0 1 1 1 0 AAA ATPase domain UvrD-helicase PF00580.21 CCF36659.1 - 0.14 11.6 0.4 1.2 8.6 0.4 2.2 1 1 0 1 1 1 0 UvrD/REP helicase N-terminal domain Sugar_tr PF00083.24 CCF36660.1 - 4.1e-42 144.6 3.2 4.8e-42 144.4 3.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF36660.1 - 1.6e-12 47.0 5.9 2e-12 46.7 5.9 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 CCF36660.1 - 7.9e-05 21.3 1.0 9.8e-05 21.0 1.0 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Folate_carrier PF01770.18 CCF36660.1 - 0.001 17.9 2.1 0.002 17.0 2.1 1.4 1 0 0 1 1 1 1 Reduced folate carrier EpsG PF14897.6 CCF36660.1 - 0.048 13.0 6.5 0.14 11.4 6.7 1.7 1 1 1 2 2 2 0 EpsG family DUF764 PF05561.11 CCF36660.1 - 0.057 13.2 0.2 10 5.9 0.0 2.3 2 0 0 2 2 2 0 Borrelia burgdorferi protein of unknown function (DUF764) Phage_holin_3_2 PF04550.12 CCF36660.1 - 0.086 13.4 2.8 0.17 12.4 2.8 1.5 1 0 0 1 1 1 0 Phage holin family 2 DUF1304 PF06993.12 CCF36660.1 - 0.26 11.3 5.6 0.077 13.0 1.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1304) DUF1240 PF06836.12 CCF36660.1 - 0.32 11.5 2.1 0.98 10.0 0.2 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1240) Glyco_hydro_43 PF04616.14 CCF36661.1 - 1.9e-35 122.6 6.0 2.6e-35 122.2 6.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 GH43_C2 PF17851.1 CCF36661.1 - 1.8e-18 67.0 0.0 3.2e-18 66.2 0.0 1.4 1 0 0 1 1 1 1 Beta xylosidase C-terminal Concanavalin A-like domain DUF676 PF05057.14 CCF36662.1 - 2.3e-05 24.0 0.0 3.7e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_6 PF12697.7 CCF36662.1 - 0.0012 19.5 0.2 0.0014 19.3 0.2 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.13 CCF36662.1 - 0.0018 18.0 0.0 0.003 17.3 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_9 PF10081.9 CCF36662.1 - 0.0047 16.1 0.0 0.0096 15.0 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta-hydrolase family Abhydrolase_8 PF06259.12 CCF36662.1 - 0.01 15.5 0.0 0.023 14.3 0.0 1.6 1 0 0 1 1 1 0 Alpha/beta hydrolase LCAT PF02450.15 CCF36662.1 - 0.048 12.8 0.0 0.066 12.4 0.0 1.1 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase Tyrosinase PF00264.20 CCF36663.1 - 2.2e-25 90.2 0.1 6.6e-25 88.7 0.1 1.8 1 1 0 1 1 1 1 Common central domain of tyrosinase NPR3 PF03666.13 CCF36664.1 - 0.096 11.5 2.8 0.096 11.5 2.8 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Raftlin PF15250.6 CCF36664.1 - 0.26 10.0 4.4 0.3 9.8 4.4 1.1 1 0 0 1 1 1 0 Raftlin SLC12 PF03522.15 CCF36664.1 - 2.4 7.1 6.5 2.8 6.9 6.5 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Neur_chan_memb PF02932.16 CCF36664.1 - 2.5 8.1 5.1 3.2 7.7 5.1 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Zip PF02535.22 CCF36664.1 - 2.7 7.1 3.9 2.9 7.0 3.9 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 CCF36664.1 - 2.7 6.7 10.2 3.2 6.4 10.2 1.1 1 0 0 1 1 1 0 Presenilin Suf PF05843.14 CCF36664.1 - 4.4 7.2 6.6 5.5 6.9 6.6 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) RT_RNaseH PF17917.1 CCF36665.1 - 8e-24 83.9 0.0 1.7e-23 82.9 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CCF36665.1 - 4.7e-19 68.3 0.0 9.4e-19 67.3 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 CCF36665.1 - 4.3e-07 30.1 0.0 9.6e-07 29.0 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain AA_permease PF00324.21 CCF36666.1 - 6.8e-120 400.9 43.9 8.5e-120 400.6 43.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CCF36666.1 - 4.6e-31 108.1 44.3 6.2e-31 107.7 44.3 1.1 1 0 0 1 1 1 1 Amino acid permease ATP-synt_8 PF00895.20 CCF36666.1 - 6.7 7.2 5.8 16 6.0 0.2 2.9 2 0 0 2 2 2 0 ATP synthase protein 8 Fungal_trans PF04082.18 CCF36668.1 - 2e-09 36.9 0.3 3e-09 36.3 0.3 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain RsbRD_N PF14361.6 CCF36668.1 - 0.065 13.9 0.8 0.18 12.5 0.4 1.9 2 0 0 2 2 2 0 RsbT co-antagonist protein rsbRD N-terminal domain CHASE6_C PF17150.4 CCF36668.1 - 0.13 13.0 0.1 0.24 12.1 0.1 1.4 1 0 0 1 1 1 0 C-terminal domain of two-partite extracellular sensor domain DUF1205 PF06722.12 CCF36669.1 - 0.065 13.3 1.1 2.7 8.2 0.6 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1205) Aldo_ket_red PF00248.21 CCF36670.1 - 6.8e-40 137.1 0.0 8.2e-40 136.8 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family NAD_binding_6 PF08030.12 CCF36670.1 - 0.086 13.0 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Ferric reductase NAD binding domain TAFII28 PF04719.14 CCF36671.1 - 3.2e-32 110.5 0.2 7.9e-32 109.2 0.2 1.7 1 1 0 1 1 1 1 hTAFII28-like protein conserved region TT_ORF2 PF02957.15 CCF36671.1 - 6.7 7.7 7.2 1.1 10.2 2.6 2.1 2 0 0 2 2 2 0 TT viral ORF2 GTP_cyclohydroI PF01227.22 CCF36672.1 - 6.6e-75 250.5 0.4 8.7e-75 250.1 0.4 1.1 1 0 0 1 1 1 1 GTP cyclohydrolase I QueF PF14489.6 CCF36672.1 - 0.0032 17.6 0.0 0.006 16.7 0.0 1.4 1 0 0 1 1 1 1 QueF-like protein Aa_trans PF01490.18 CCF36673.1 - 6.3e-11 41.6 4.9 8.6e-11 41.2 4.9 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Mo-co_dimer PF03404.16 CCF36674.1 - 4.7e-61 204.8 0.1 9.5e-61 203.8 0.1 1.5 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain Oxidored_molyb PF00174.19 CCF36674.1 - 2.6e-55 186.7 0.0 4.2e-55 186.0 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain FAD_binding_6 PF00970.24 CCF36674.1 - 1.5e-33 115.1 0.0 2.6e-33 114.3 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain Cyt-b5 PF00173.28 CCF36674.1 - 3.9e-20 71.8 0.0 8.7e-20 70.6 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain NAD_binding_1 PF00175.21 CCF36674.1 - 4.9e-12 46.4 0.0 1.4e-11 44.9 0.0 1.8 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 CCF36674.1 - 0.059 13.5 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 Ferric reductase NAD binding domain AIRC PF00731.20 CCF36676.1 - 4.5e-61 204.8 1.4 9.3e-61 203.7 0.8 1.9 2 0 0 2 2 2 1 AIR carboxylase ATP-grasp PF02222.22 CCF36676.1 - 4.4e-50 169.6 0.0 9e-50 168.6 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain PurK_C PF17769.1 CCF36676.1 - 1.3e-13 50.4 0.0 2.9e-13 49.3 0.0 1.6 1 0 0 1 1 1 1 Phosphoribosylaminoimidazole carboxylase C-terminal domain Dala_Dala_lig_C PF07478.13 CCF36676.1 - 1.3e-06 28.1 0.0 2.8e-06 27.0 0.0 1.6 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus PrpR_N PF06506.11 CCF36676.1 - 0.0054 16.3 0.0 0.098 12.2 0.0 2.5 3 0 0 3 3 3 1 Propionate catabolism activator XdhC_C PF13478.6 CCF36676.1 - 0.04 14.4 0.1 5.8 7.4 0.0 2.6 2 0 0 2 2 2 0 XdhC Rossmann domain CPSase_L_D2 PF02786.17 CCF36677.1 - 3.5e-85 284.8 0.0 6.4e-85 283.9 0.0 1.4 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp PF02222.22 CCF36677.1 - 3.3e-09 36.6 0.0 5.1e-09 35.9 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 CCF36677.1 - 6.8e-09 35.6 0.0 1.3e-08 34.6 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.6 CCF36677.1 - 0.00013 21.7 0.0 0.00027 20.7 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_5 PF13549.6 CCF36677.1 - 0.023 14.2 0.1 0.065 12.7 0.1 1.8 1 1 0 1 1 1 0 ATP-grasp domain GARS_A PF01071.19 CCF36677.1 - 0.049 13.4 0.2 0.17 11.6 0.0 1.9 2 0 0 2 2 2 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Glyco_hydro_3_C PF01915.22 CCF36678.1 - 8.7e-66 221.8 0.0 1.6e-65 220.9 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 CCF36678.1 - 9.3e-49 166.5 0.0 1.6e-48 165.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 CCF36678.1 - 5e-23 81.0 0.2 1e-22 80.0 0.2 1.6 1 0 0 1 1 1 1 Fibronectin type III-like domain PA14 PF07691.12 CCF36678.1 - 6.5e-11 42.2 0.1 1.3e-10 41.3 0.1 1.4 1 0 0 1 1 1 1 PA14 domain Lipase_GDSL_2 PF13472.6 CCF36678.1 - 0.07 13.5 0.0 0.17 12.3 0.0 1.6 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family DUF3327 PF11806.8 CCF36678.1 - 0.14 12.8 0.3 0.32 11.7 0.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3327) Zn_clus PF00172.18 CCF36679.1 - 0.025 14.7 4.7 1.8 8.7 0.2 2.3 1 1 1 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain OsmC PF02566.19 CCF36680.1 - 5.2e-17 62.2 0.0 8e-17 61.6 0.0 1.3 1 0 0 1 1 1 1 OsmC-like protein ATG2_CAD PF13329.6 CCF36682.1 - 1.3e-21 76.9 0.1 2.6e-21 75.9 0.1 1.5 1 0 0 1 1 1 1 Autophagy-related protein 2 CAD motif Chorein_N PF12624.7 CCF36682.1 - 9.1e-07 29.0 0.1 2.3e-06 27.7 0.1 1.6 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 OPT PF03169.15 CCF36683.1 - 4.7e-91 306.3 20.6 5.4e-91 306.1 20.6 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Acetyltransf_3 PF13302.7 CCF36684.1 - 2e-14 54.5 0.0 3.7e-14 53.6 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CCF36684.1 - 0.00014 22.0 0.1 0.00023 21.4 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Fringe PF02434.16 CCF36685.1 - 0.038 13.4 0.0 0.06 12.8 0.0 1.2 1 0 0 1 1 1 0 Fringe-like NAD_binding_10 PF13460.6 CCF36686.1 - 2.4e-15 56.9 0.0 2.9e-15 56.7 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 CCF36686.1 - 4.8e-14 52.5 0.0 5.9e-14 52.2 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 CCF36686.1 - 3.1e-08 33.4 0.1 7.2e-08 32.2 0.1 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 CCF36686.1 - 1.7e-06 28.1 0.0 2.1e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 KR domain TrkA_N PF02254.18 CCF36686.1 - 2.7e-05 24.4 0.1 3.3e-05 24.1 0.1 1.3 1 1 0 1 1 1 1 TrkA-N domain Shikimate_DH PF01488.20 CCF36686.1 - 0.0014 18.7 0.1 0.0019 18.3 0.1 1.1 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase adh_short PF00106.25 CCF36686.1 - 0.0026 17.3 0.1 0.0033 16.9 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase PglD_N PF17836.1 CCF36686.1 - 0.0032 18.1 0.1 0.0053 17.4 0.1 1.4 1 0 0 1 1 1 1 PglD N-terminal domain Sacchrp_dh_NADP PF03435.18 CCF36686.1 - 0.0034 17.6 0.1 0.006 16.8 0.1 1.4 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Polysacc_synt_2 PF02719.15 CCF36686.1 - 0.0035 16.5 0.1 0.0051 16.0 0.1 1.4 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein LpxI_N PF17930.1 CCF36686.1 - 0.0096 15.8 0.0 0.014 15.3 0.0 1.3 1 0 0 1 1 1 1 LpxI N-terminal domain GDP_Man_Dehyd PF16363.5 CCF36686.1 - 0.058 12.8 0.1 0.13 11.6 0.0 1.6 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase DapB_N PF01113.20 CCF36686.1 - 0.16 12.1 1.1 6.5 6.9 0.2 2.1 1 1 1 2 2 2 0 Dihydrodipicolinate reductase, N-terminus FAD_binding_3 PF01494.19 CCF36687.1 - 6.5e-24 84.8 0.0 9.6e-14 51.4 0.0 2.0 2 0 0 2 2 2 2 FAD binding domain Lycopene_cycl PF05834.12 CCF36687.1 - 0.0025 16.9 0.1 3.1 6.7 0.1 2.9 3 0 0 3 3 3 2 Lycopene cyclase protein Pyr_redox PF00070.27 CCF36687.1 - 0.017 15.7 0.1 0.017 15.7 0.1 2.1 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CCF36687.1 - 0.027 13.7 1.6 0.078 12.2 0.1 2.3 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCF36687.1 - 0.027 13.7 0.4 0.96 8.6 0.2 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 CCF36687.1 - 0.054 12.8 0.0 0.81 8.9 0.0 2.1 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CCF36687.1 - 0.085 13.1 0.1 0.2 11.9 0.1 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain MFS_1 PF07690.16 CCF36688.1 - 1.4e-11 44.0 55.2 8.4e-08 31.5 30.8 2.6 1 1 1 2 2 2 2 Major Facilitator Superfamily Pox_A14 PF05767.12 CCF36688.1 - 0.57 10.4 8.5 0.11 12.7 2.7 2.7 2 0 0 2 2 2 0 Poxvirus virion envelope protein A14 SnoaL_2 PF12680.7 CCF36689.1 - 1.1e-09 38.8 0.2 1.4e-09 38.5 0.2 1.1 1 0 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.6 CCF36689.1 - 0.0011 19.3 0.0 0.0015 18.9 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) SnoaL PF07366.12 CCF36689.1 - 0.083 12.7 0.0 2.6 7.9 0.0 2.2 1 1 1 2 2 2 0 SnoaL-like polyketide cyclase 2-Hacid_dh_C PF02826.19 CCF36690.1 - 3.4e-41 140.6 0.0 2.7e-29 101.8 0.0 2.1 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain W2 PF02020.18 CCF36691.1 - 3.4e-22 78.4 2.7 7.2e-22 77.3 2.7 1.6 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon Hexapep PF00132.24 CCF36691.1 - 4.5e-07 29.3 6.9 0.00027 20.5 1.6 4.0 1 1 2 3 3 3 2 Bacterial transferase hexapeptide (six repeats) NTP_transferase PF00483.23 CCF36691.1 - 0.001 18.7 0.0 0.0017 18.0 0.0 1.3 1 0 0 1 1 1 1 Nucleotidyl transferase DUF4954 PF16314.5 CCF36691.1 - 0.0059 14.8 0.1 0.0094 14.1 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) NTP_transf_3 PF12804.7 CCF36691.1 - 0.017 15.5 0.0 0.045 14.1 0.0 1.7 1 0 0 1 1 1 0 MobA-like NTP transferase domain Fucokinase PF07959.12 CCF36691.1 - 0.058 12.3 0.5 0.71 8.7 0.5 2.1 1 1 0 1 1 1 0 L-fucokinase Hexapep_2 PF14602.6 CCF36691.1 - 0.13 12.0 7.6 0.33 10.8 1.2 3.5 2 2 1 3 3 3 0 Hexapeptide repeat of succinyl-transferase HAD_SAK_1 PF10307.9 CCF36692.1 - 1.1e-79 267.0 0.0 1.5e-79 266.6 0.0 1.2 1 0 0 1 1 1 1 HAD domain family 1 in Swiss Army Knife RNA repair proteins DIOX_N PF14226.6 CCF36693.1 - 3.4e-25 89.1 0.1 5.1e-25 88.5 0.1 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 CCF36693.1 - 8.1e-20 71.2 0.3 2.9e-19 69.4 0.0 1.9 3 0 0 3 3 3 1 2OG-Fe(II) oxygenase superfamily LPD26 PF18842.1 CCF36693.1 - 0.2 11.6 0.1 0.62 10.1 0.0 1.8 2 0 0 2 2 2 0 Large polyvalent protein associated domain 26 MFS_1 PF07690.16 CCF36695.1 - 1.8e-29 102.8 33.3 1.8e-29 102.8 33.3 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF36695.1 - 2.2e-07 30.1 17.3 2.2e-07 30.1 17.3 3.3 2 2 1 3 3 3 1 Sugar (and other) transporter Metallophos PF00149.28 CCF36697.1 - 5.1e-08 33.7 0.4 1.1e-07 32.5 0.4 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CCF36697.1 - 1.9e-05 24.9 0.0 0.00023 21.4 0.0 2.0 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Sugar_tr PF00083.24 CCF36699.1 - 2.9e-87 293.4 13.6 3.2e-87 293.3 13.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF36699.1 - 3.3e-30 105.2 22.1 1e-25 90.5 2.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 CCF36699.1 - 0.00016 20.4 15.0 0.00038 19.1 2.6 2.6 2 1 0 2 2 2 2 MFS/sugar transport protein PUCC PF03209.15 CCF36699.1 - 0.0018 17.4 2.8 0.0018 17.4 2.8 2.9 2 1 1 3 3 3 2 PUCC protein OATP PF03137.20 CCF36699.1 - 1.5 7.0 13.5 0.083 11.2 1.2 2.9 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family Glyco_hydro_28 PF00295.17 CCF36700.1 - 7.1e-49 166.6 4.8 1e-48 166.1 4.8 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Beta_helix PF13229.6 CCF36700.1 - 0.0036 17.2 8.3 0.0063 16.4 8.3 1.5 1 0 0 1 1 1 1 Right handed beta helix region GST_C PF00043.25 CCF36702.1 - 1.4e-13 50.9 0.0 3.4e-13 49.6 0.0 1.8 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 CCF36702.1 - 5.1e-12 46.0 0.0 1.1e-11 44.9 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CCF36702.1 - 4.4e-07 29.8 0.0 1e-06 28.6 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 CCF36702.1 - 0.00012 22.3 0.0 0.00029 21.0 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 CCF36702.1 - 0.00018 21.8 0.0 0.00036 20.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Ribosomal_S9 PF00380.19 CCF36703.1 - 2.2e-40 138.0 0.2 3.3e-40 137.4 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein S9/S16 KR PF08659.10 CCF36705.1 - 4e-57 193.0 0.0 8.9e-57 191.9 0.0 1.6 1 0 0 1 1 1 1 KR domain PS-DH PF14765.6 CCF36705.1 - 1.1e-44 152.9 1.3 1.9e-43 148.8 1.3 2.3 1 1 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 CCF36705.1 - 2.2e-41 142.4 0.0 4.6e-41 141.4 0.0 1.5 1 1 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 CCF36705.1 - 5.4e-32 110.3 0.1 1.7e-31 108.7 0.0 2.0 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 CCF36705.1 - 2.2e-18 66.8 0.0 5.5e-18 65.4 0.0 1.8 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension adh_short PF00106.25 CCF36705.1 - 2.2e-05 24.0 0.0 5.9e-05 22.6 0.0 1.7 1 0 0 1 1 1 1 short chain dehydrogenase OrsD PF12013.8 CCF36708.1 - 4.6e-16 59.3 0.3 2.6e-15 56.8 0.1 1.9 2 0 0 2 2 2 1 Orsellinic acid/F9775 biosynthesis cluster protein D 4HBT PF03061.22 CCF36709.1 - 5.9e-08 33.0 0.0 8.1e-08 32.5 0.0 1.2 1 0 0 1 1 1 1 Thioesterase superfamily NmrA PF05368.13 CCF36710.1 - 4.1e-17 62.5 0.2 5.2e-17 62.2 0.2 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CCF36710.1 - 6.9e-14 52.2 0.1 1.4e-13 51.1 0.1 1.6 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CCF36710.1 - 1.8e-07 30.9 0.0 3.2e-06 26.8 0.0 2.1 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CCF36710.1 - 7.6e-05 21.8 0.0 0.00012 21.2 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family F420_oxidored PF03807.17 CCF36710.1 - 0.00081 19.9 1.0 0.0022 18.5 0.5 1.9 1 1 1 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent KR PF08659.10 CCF36710.1 - 0.0013 18.7 0.1 0.0021 18.0 0.1 1.3 1 0 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.18 CCF36710.1 - 0.008 16.4 0.0 0.013 15.7 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Polysacc_synt_2 PF02719.15 CCF36710.1 - 0.021 14.0 0.0 0.034 13.3 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein DapB_N PF01113.20 CCF36710.1 - 0.027 14.6 0.5 0.056 13.6 0.5 1.6 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Glyoxalase_3 PF13468.6 CCF36710.1 - 0.029 14.5 0.0 0.049 13.7 0.0 1.3 1 0 0 1 1 1 0 Glyoxalase-like domain GDP_Man_Dehyd PF16363.5 CCF36710.1 - 0.031 13.7 0.0 0.82 9.0 0.1 2.1 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase LpxI_N PF17930.1 CCF36710.1 - 0.058 13.3 0.2 0.55 10.1 0.2 2.1 2 0 0 2 2 2 0 LpxI N-terminal domain RmlD_sub_bind PF04321.17 CCF36710.1 - 0.14 11.2 0.3 0.3 10.2 0.3 1.4 1 0 0 1 1 1 0 RmlD substrate binding domain VMA21 PF09446.10 CCF36711.1 - 1.8e-16 60.0 9.3 2.5e-16 59.5 9.3 1.2 1 0 0 1 1 1 1 VMA21-like domain DUF2406 PF10295.9 CCF36712.1 - 3.2e-27 95.0 0.5 3.2e-27 95.0 0.5 2.3 2 0 0 2 2 2 1 Uncharacterised protein (DUF2406) TFIIA PF03153.13 CCF36712.1 - 4.5 7.2 27.5 5.1 7.0 12.1 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Ribosomal_L35Ae PF01247.18 CCF36714.1 - 1.9e-41 140.1 0.6 2.2e-41 139.9 0.6 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.18 CCF36714.1 - 1.9e-05 24.8 0.1 0.017 15.3 0.0 2.2 2 0 0 2 2 2 2 RimM N-terminal domain Citrate_bind PF16114.5 CCF36715.1 - 2.8e-89 297.3 0.0 3.1e-89 297.2 0.0 1.0 1 0 0 1 1 1 1 ATP citrate lyase citrate-binding Reovirus_M2 PF05993.12 CCF36715.1 - 0.0039 15.4 0.0 0.0045 15.2 0.0 1.0 1 0 0 1 1 1 1 Reovirus major virion structural protein Mu-1/Mu-1C (M2) Response_reg PF00072.24 CCF36717.1 - 8.2e-21 74.3 0.0 1.9e-14 53.8 0.0 2.3 2 0 0 2 2 2 2 Response regulator receiver domain Bot1p PF12298.8 CCF36718.1 - 4.5e-48 163.7 5.0 6.4e-48 163.2 5.0 1.3 1 0 0 1 1 1 1 Eukaryotic mitochondrial regulator protein KR PF08659.10 CCF36719.1 - 1.7e-55 187.8 0.1 2.4e-55 187.2 0.1 1.3 1 0 0 1 1 1 1 KR domain adh_short PF00106.25 CCF36719.1 - 1.1e-10 41.2 0.1 2.2e-10 40.3 0.1 1.4 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF36719.1 - 1.6e-06 27.9 0.0 3.4e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase PP-binding PF00550.25 CCF36719.1 - 0.0044 17.3 0.1 0.011 16.0 0.1 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site Polysacc_synt_2 PF02719.15 CCF36719.1 - 0.043 13.0 0.0 0.07 12.2 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Epimerase PF01370.21 CCF36719.1 - 0.044 13.2 0.0 0.076 12.5 0.0 1.4 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family PX PF00787.24 CCF36719.1 - 0.2 11.7 0.0 0.35 10.9 0.0 1.4 1 0 0 1 1 1 0 PX domain DUF4149 PF13664.6 CCF36720.1 - 1.5e-21 76.6 0.7 2e-21 76.2 0.1 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4149) Erg28 PF03694.13 CCF36720.1 - 0.05 14.0 0.3 0.09 13.2 0.3 1.4 1 0 0 1 1 1 0 Erg28 like protein DUF4976 PF16347.5 CCF36721.1 - 0.0073 16.5 0.0 0.015 15.5 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4976) PH PF00169.29 CCF36722.1 - 0.092 13.3 0.0 0.19 12.2 0.0 1.6 1 0 0 1 1 1 0 PH domain G-patch PF01585.23 CCF36724.1 - 8.1e-05 22.4 0.3 0.00018 21.4 0.3 1.6 1 0 0 1 1 1 1 G-patch domain GRIN_C PF15235.6 CCF36724.1 - 0.0021 18.3 0.6 0.0041 17.4 0.6 1.4 1 0 0 1 1 1 1 G protein-regulated inducer of neurite outgrowth C-terminus DUF2116 PF09889.9 CCF36724.1 - 1.3 9.1 3.3 2.3 8.3 0.8 2.3 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) adh_short PF00106.25 CCF36725.1 - 2.4e-12 46.7 0.1 1.2e-11 44.5 0.0 2.2 2 1 0 2 2 2 1 short chain dehydrogenase Epimerase PF01370.21 CCF36725.1 - 0.00012 21.6 0.0 0.00021 20.8 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family adh_short_C2 PF13561.6 CCF36725.1 - 0.00086 18.9 0.0 0.0021 17.7 0.0 1.6 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF36725.1 - 0.0045 16.9 0.0 0.0089 15.9 0.0 1.5 1 0 0 1 1 1 1 KR domain E1-N PF14463.6 CCF36725.1 - 0.024 14.5 0.1 0.037 13.8 0.1 1.3 1 0 0 1 1 1 0 E1 N-terminal domain AAA_11 PF13086.6 CCF36725.1 - 0.058 13.2 6.8 1.3 8.7 8.4 2.0 2 0 0 2 2 2 0 AAA domain Presenilin PF01080.17 CCF36725.1 - 0.23 10.2 1.2 0.3 9.8 1.2 1.2 1 0 0 1 1 1 0 Presenilin Synaptobrevin PF00957.21 CCF36726.1 - 1.8e-24 85.3 0.0 2.3e-24 85.0 0.0 1.1 1 0 0 1 1 1 1 Synaptobrevin HeLo PF14479.6 CCF36728.1 - 1.3e-27 97.0 1.9 2.2e-27 96.2 1.9 1.4 1 0 0 1 1 1 1 Prion-inhibition and propagation Pkinase PF00069.25 CCF36728.1 - 0.0003 20.2 0.0 0.00052 19.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF36728.1 - 0.0035 16.7 0.1 0.014 14.7 0.1 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase DUF3322 PF11795.8 CCF36728.1 - 0.011 15.8 0.1 0.044 13.8 0.0 2.0 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria N-term (DUF3322) HCMVantigenic_N PF12154.8 CCF36730.1 - 0.0053 16.8 2.3 1.7 8.9 0.0 3.3 2 0 0 2 2 2 1 Glycoprotein B N-terminal antigenic domain of HCMV GLTSCR1 PF15249.6 CCF36730.1 - 0.091 13.2 1.9 0.25 11.8 1.9 1.9 1 1 0 1 1 1 0 Conserved region of unknown function on GLTSCR protein UBA_3 PF09288.10 CCF36730.1 - 0.18 11.6 0.1 0.37 10.6 0.1 1.5 1 0 0 1 1 1 0 Fungal ubiquitin-associated domain SOGA PF11365.8 CCF36730.1 - 2.3 9.4 8.7 0.15 13.2 0.9 2.9 3 0 0 3 3 3 0 Protein SOGA FapA PF03961.13 CCF36730.1 - 4.5 5.8 7.9 0.17 10.4 2.1 1.5 2 0 0 2 2 2 0 Flagellar Assembly Protein A TMEM72 PF16054.5 CCF36732.1 - 0.084 12.6 0.2 1.9 8.2 0.0 2.0 1 1 1 2 2 2 0 Transmembrane protein family 72 Mito_carr PF00153.27 CCF36733.1 - 1e-47 160.0 2.0 2.6e-19 68.9 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Heliorhodopsin PF18761.1 CCF36733.1 - 0.12 11.7 0.5 8.8 5.6 0.0 2.5 2 0 0 2 2 2 0 Heliorhodopsin Methyltransf_23 PF13489.6 CCF36734.1 - 7e-12 45.5 0.0 9.8e-12 45.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF36734.1 - 3.4e-11 43.2 0.0 4.2e-11 42.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF36734.1 - 1.8e-10 41.3 0.1 5.6e-10 39.7 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF36734.1 - 1.9e-09 38.1 0.1 4.8e-09 36.8 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF36734.1 - 3.4e-08 34.1 0.0 5.8e-08 33.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCF36734.1 - 0.091 12.1 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Pyr_redox_2 PF07992.14 CCF36735.1 - 7e-09 35.3 0.0 7.6e-09 35.2 0.0 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCF36735.1 - 2e-05 24.7 0.1 2.6e-05 24.4 0.1 1.4 1 1 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 CCF36735.1 - 5.3e-05 22.1 0.0 0.0022 16.8 0.0 2.0 2 0 0 2 2 2 1 HI0933-like protein FAD_binding_3 PF01494.19 CCF36735.1 - 6.3e-05 22.4 0.0 9.6e-05 21.8 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 CCF36735.1 - 0.00027 20.7 0.3 0.00037 20.2 0.2 1.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 CCF36735.1 - 0.00055 19.9 0.2 0.082 12.9 0.0 2.1 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox_3 PF13738.6 CCF36735.1 - 0.00084 18.7 0.4 0.0052 16.1 0.2 1.9 1 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CCF36735.1 - 0.001 18.3 0.4 0.0017 17.5 0.3 1.4 1 1 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 CCF36735.1 - 0.0034 16.7 0.0 0.0054 16.0 0.0 1.3 1 0 0 1 1 1 1 Thi4 family Lycopene_cycl PF05834.12 CCF36735.1 - 0.0064 15.6 0.6 0.015 14.4 0.2 1.6 1 1 1 2 2 2 1 Lycopene cyclase protein GIDA PF01134.22 CCF36735.1 - 0.0091 15.1 0.2 0.029 13.5 0.1 1.7 1 1 1 2 2 2 1 Glucose inhibited division protein A K_oxygenase PF13434.6 CCF36735.1 - 0.022 13.9 0.2 1 8.5 0.1 2.0 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) FAD_oxidored PF12831.7 CCF36735.1 - 0.036 13.4 0.1 0.06 12.7 0.1 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase Trp_halogenase PF04820.14 CCF36735.1 - 0.051 12.4 0.0 0.068 12.0 0.0 1.1 1 0 0 1 1 1 0 Tryptophan halogenase PIEZO PF15917.5 CCF36736.1 - 0.12 11.8 3.7 0.17 11.4 3.7 1.2 1 0 0 1 1 1 0 Piezo rRNA_processing PF08524.11 CCF36736.1 - 0.14 12.2 8.3 0.17 11.9 8.0 1.4 1 1 0 1 1 1 0 rRNA processing Suf PF05843.14 CCF36736.1 - 0.14 12.1 7.2 0.2 11.6 7.2 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Presenilin PF01080.17 CCF36736.1 - 5.3 5.7 4.9 6.4 5.4 4.9 1.1 1 0 0 1 1 1 0 Presenilin 4HBT PF03061.22 CCF36737.1 - 4e-09 36.7 0.1 6.7e-09 36.0 0.1 1.3 1 0 0 1 1 1 1 Thioesterase superfamily Coiled PF05710.12 CCF36737.1 - 0.0093 16.8 2.8 0.014 16.2 2.8 1.3 1 0 0 1 1 1 1 Coiled coil SR-25 PF10500.9 CCF36737.1 - 0.089 12.4 7.3 0.11 12.1 7.3 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein MFS_1 PF07690.16 CCF36738.1 - 6e-27 94.5 19.0 6e-27 94.5 19.0 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_1_like PF12832.7 CCF36738.1 - 0.0011 17.9 0.5 0.2 10.5 0.7 2.5 2 0 0 2 2 2 2 MFS_1 like family Pectate_lyase PF03211.13 CCF36739.1 - 2.8e-84 281.7 9.8 3.4e-84 281.5 9.8 1.0 1 0 0 1 1 1 1 Pectate lyase Pkinase PF00069.25 CCF36740.1 - 2.9e-65 220.3 0.0 3.9e-65 219.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF36740.1 - 3e-40 138.1 0.1 4.4e-40 137.6 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase POLO_box PF00659.18 CCF36740.1 - 2.1e-05 24.6 0.0 0.0041 17.3 0.0 2.8 2 0 0 2 2 2 1 POLO box duplicated region Kinase-like PF14531.6 CCF36740.1 - 3.4e-05 23.3 0.0 5.4e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 CCF36740.1 - 0.0037 16.6 0.0 0.0068 15.8 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 CCF36740.1 - 0.017 13.9 0.1 0.036 12.8 0.1 1.5 1 0 0 1 1 1 0 Fungal protein kinase OPA3 PF07047.12 CCF36741.1 - 1.8e-47 160.2 1.3 2.8e-47 159.6 1.3 1.4 1 0 0 1 1 1 1 Optic atrophy 3 protein (OPA3) HXXSHH PF07586.11 CCF36741.1 - 0.27 10.8 6.4 0.04 13.5 0.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1552) DUF755 PF05501.11 CCF36741.1 - 0.3 11.4 10.1 0.84 9.9 10.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF755) HAUS6_N PF14661.6 CCF36741.1 - 0.52 9.9 8.2 0.47 10.0 1.4 2.1 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus SR-25 PF10500.9 CCF36741.1 - 0.58 9.7 20.2 0.02 14.5 14.1 1.6 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein DUF2681 PF10883.8 CCF36741.1 - 0.87 10.0 5.5 5 7.6 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2681) Herpes_DNAp_acc PF04929.12 CCF36741.1 - 1.8 7.4 7.7 3.3 6.6 7.7 1.3 1 0 0 1 1 1 0 Herpes DNA replication accessory factor GREB1 PF15782.5 CCF36741.1 - 2.3 5.2 7.8 2.8 5.0 7.8 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer GAGA_bind PF06217.12 CCF36741.1 - 3.9 7.7 8.7 1.4 9.1 5.5 1.7 2 0 0 2 2 2 0 GAGA binding protein-like family Cwf_Cwc_15 PF04889.12 CCF36741.1 - 9.1 5.9 15.1 2.8 7.6 4.4 2.1 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein YopE PF03545.13 CCF36742.1 - 0.073 13.2 0.2 0.19 11.9 0.1 1.7 2 0 0 2 2 2 0 Yersinia virulence determinant (YopE) She9_MDM33 PF05546.11 CCF36743.1 - 1.6e-62 210.9 8.0 2e-62 210.5 8.0 1.1 1 0 0 1 1 1 1 She9 / Mdm33 family SOG2 PF10428.9 CCF36743.1 - 0.015 14.5 18.0 0.018 14.3 18.0 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Citrate_synt PF00285.21 CCF36743.1 - 0.017 14.2 2.2 0.026 13.6 1.4 1.6 1 1 1 2 2 2 0 Citrate synthase, C-terminal domain DUF1319 PF07028.11 CCF36743.1 - 0.056 13.7 0.2 0.31 11.3 0.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1319) Erythro-docking PF09277.11 CCF36743.1 - 0.19 11.7 1.5 3.3 7.7 0.1 2.7 2 0 0 2 2 2 0 Erythronolide synthase, docking Tropomyosin_1 PF12718.7 CCF36743.1 - 1.9 8.6 8.2 1 9.5 1.6 2.1 1 1 1 2 2 2 0 Tropomyosin like Mito_carr PF00153.27 CCF36744.1 - 6.4e-65 215.1 5.3 9.9e-24 83.1 0.2 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF4748 PF15932.5 CCF36744.1 - 0.15 11.8 1.5 0.58 9.9 1.5 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4748) Abhydrolase_3 PF07859.13 CCF36745.1 - 1.8e-40 139.1 0.0 2.3e-40 138.7 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 CCF36745.1 - 0.00041 19.4 0.0 0.0005 19.1 0.0 1.2 1 0 0 1 1 1 1 Carboxylesterase family Peptidase_S9 PF00326.21 CCF36745.1 - 0.00062 19.3 0.0 0.5 9.8 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family DLH PF01738.18 CCF36745.1 - 0.11 12.0 0.0 0.18 11.3 0.0 1.2 1 0 0 1 1 1 0 Dienelactone hydrolase family OPT PF03169.15 CCF36746.1 - 3.3e-129 432.3 45.2 3.8e-129 432.1 45.2 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein HET PF06985.11 CCF36747.1 - 1e-29 103.8 0.2 1.7e-29 103.0 0.2 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Thioredoxin PF00085.20 CCF36748.1 - 1.1e-27 96.0 0.0 1.4e-27 95.6 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.13 CCF36748.1 - 4.7e-05 22.9 0.0 5.1e-05 22.8 0.0 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Redoxin PF08534.10 CCF36748.1 - 5.4e-05 22.9 0.0 0.00015 21.5 0.0 1.6 1 1 0 1 1 1 1 Redoxin Thioredoxin_9 PF14595.6 CCF36748.1 - 5.7e-05 22.9 0.0 6.9e-05 22.6 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 CCF36748.1 - 6.7e-05 23.1 0.0 0.00047 20.4 0.0 1.9 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.6 CCF36748.1 - 7.9e-05 23.1 0.0 0.00027 21.4 0.0 1.7 1 1 0 1 1 1 1 Thioredoxin-like domain Glutaredoxin PF00462.24 CCF36748.1 - 0.00092 19.4 0.0 0.0024 18.0 0.0 1.7 1 1 1 2 2 2 1 Glutaredoxin Thioredoxin_7 PF13899.6 CCF36748.1 - 0.00097 19.3 0.0 0.0017 18.5 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.21 CCF36748.1 - 0.0021 18.0 0.0 0.0027 17.6 0.0 1.3 1 1 0 1 1 1 1 AhpC/TSA family TraF PF13728.6 CCF36748.1 - 0.0041 17.0 0.0 0.005 16.7 0.0 1.1 1 0 0 1 1 1 1 F plasmid transfer operon protein DAO PF01266.24 CCF36749.1 - 2.8e-36 125.8 2.1 3.2e-36 125.6 2.1 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CCF36749.1 - 0.00031 20.9 0.1 0.00088 19.5 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 CCF36749.1 - 0.0031 16.6 0.0 0.0053 15.9 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 CCF36749.1 - 0.0067 15.7 1.6 0.0067 15.7 0.1 1.7 2 0 0 2 2 2 1 Thi4 family Pyr_redox PF00070.27 CCF36749.1 - 0.017 15.7 0.1 0.057 14.0 0.1 1.9 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CCF36749.1 - 0.02 14.1 0.1 0.075 12.3 0.0 1.9 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 CCF36749.1 - 0.16 10.8 0.1 0.34 9.7 0.1 1.5 2 0 0 2 2 2 0 Tryptophan halogenase HI0933_like PF03486.14 CCF36749.1 - 0.2 10.3 0.1 0.31 9.7 0.1 1.2 1 0 0 1 1 1 0 HI0933-like protein PTR2 PF00854.21 CCF36750.1 - 2.4e-22 79.3 0.2 3e-22 79.0 0.2 1.1 1 0 0 1 1 1 1 POT family DUF2534 PF10749.9 CCF36750.1 - 0.079 13.1 0.4 0.27 11.4 0.4 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2534) LapA_dom PF06305.11 CCF36750.1 - 6.4 6.7 11.1 15 5.5 0.3 3.6 4 0 0 4 4 4 0 Lipopolysaccharide assembly protein A domain Mucin PF01456.17 CCF36752.1 - 2.2 8.3 16.1 4.8 7.2 16.2 1.5 1 1 0 1 1 1 0 Mucin-like glycoprotein DNA_pol_viral_N PF00242.17 CCF36752.1 - 6 6.2 10.0 0.83 9.1 4.0 1.9 1 1 1 2 2 2 0 DNA polymerase (viral) N-terminal domain GATase PF00117.28 CCF36754.1 - 0.00072 19.4 0.0 0.00098 18.9 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I ADH_zinc_N PF00107.26 CCF36755.1 - 6.8e-20 71.4 1.4 1.1e-19 70.7 1.4 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCF36755.1 - 1.1e-19 70.4 4.3 1.5e-18 66.6 0.5 3.0 2 1 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 CCF36755.1 - 0.00016 22.7 0.0 0.00029 21.9 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase CoA_binding PF02629.19 CCF36755.1 - 0.0039 17.8 0.3 0.01 16.5 0.3 1.7 1 0 0 1 1 1 1 CoA binding domain 2-Hacid_dh_C PF02826.19 CCF36755.1 - 0.0086 15.5 0.3 0.016 14.6 0.3 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Mur_ligase PF01225.25 CCF36755.1 - 0.033 14.5 0.7 0.1 12.9 0.7 1.9 1 0 0 1 1 1 0 Mur ligase family, catalytic domain AlaDh_PNT_C PF01262.21 CCF36755.1 - 0.93 8.7 6.1 2.7 7.2 6.0 1.7 1 1 1 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Clr5 PF14420.6 CCF36756.1 - 1.1e-22 80.0 0.4 2.3e-22 79.0 0.4 1.6 1 0 0 1 1 1 1 Clr5 domain Asp_protease PF09668.10 CCF36758.1 - 8.2e-60 200.0 0.4 1.2e-59 199.5 0.4 1.3 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 CCF36758.1 - 2.3e-24 85.7 0.1 6e-24 84.4 0.1 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 CCF36758.1 - 6.3e-12 46.0 0.1 1.3e-11 44.9 0.1 1.6 1 0 0 1 1 1 1 Aspartyl protease UBA PF00627.31 CCF36758.1 - 5.3e-10 39.0 0.0 1.6e-09 37.5 0.0 1.8 1 0 0 1 1 1 1 UBA/TS-N domain ubiquitin PF00240.23 CCF36758.1 - 6.4e-08 32.2 0.0 1.5e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family RVP PF00077.20 CCF36758.1 - 9.5e-05 22.7 0.0 0.00023 21.4 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease RVP_2 PF08284.11 CCF36758.1 - 0.00011 22.0 0.0 0.00019 21.2 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease Rad60-SLD PF11976.8 CCF36758.1 - 0.11 12.3 0.1 0.26 11.1 0.0 1.7 2 0 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like Methyltransf_8 PF05148.15 CCF36759.1 - 1.1e-35 123.5 0.5 3.5e-34 118.6 0.0 2.7 2 1 1 3 3 3 1 Hypothetical methyltransferase Methyltransf_11 PF08241.12 CCF36759.1 - 4.8e-07 30.3 0.0 2.4e-06 28.1 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF36759.1 - 3.4e-05 24.5 0.1 0.0042 17.8 0.1 2.6 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF36759.1 - 0.0017 18.2 0.1 0.47 10.2 0.0 2.2 1 1 1 2 2 2 2 Methyltransferase domain MTS PF05175.14 CCF36759.1 - 0.0099 15.4 0.1 1 8.9 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase small domain Methyltransf_32 PF13679.6 CCF36759.1 - 0.014 15.4 0.0 0.03 14.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain G-gamma PF00631.22 CCF36761.1 - 8.9e-26 89.7 0.0 1.1e-25 89.3 0.0 1.2 1 0 0 1 1 1 1 GGL domain Ribosomal_L11 PF00298.19 CCF36761.1 - 0.17 12.4 0.0 0.22 12.1 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein L11, RNA binding domain zf-RING_2 PF13639.6 CCF36762.1 - 4.4e-07 30.1 13.4 6.9e-07 29.5 13.4 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 CCF36762.1 - 1.2e-05 25.0 10.2 1.8e-05 24.5 10.2 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CCF36762.1 - 3.7e-05 23.5 10.4 5.8e-05 22.9 10.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CCF36762.1 - 5.4e-05 22.9 13.4 8.4e-05 22.3 13.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 CCF36762.1 - 0.00016 21.9 9.8 0.00034 20.8 9.8 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 CCF36762.1 - 0.053 13.4 6.7 0.092 12.6 6.7 1.3 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 CCF36762.1 - 0.62 9.9 5.9 1.4 8.7 5.9 1.6 1 0 0 1 1 1 0 RING-like zinc finger zf-ANAPC11 PF12861.7 CCF36762.1 - 1.1 9.4 5.7 2.5 8.2 5.7 1.6 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Drc1-Sld2 PF11719.8 CCF36763.1 - 3.8e-93 313.5 24.6 4.3e-93 313.3 24.6 1.0 1 0 0 1 1 1 1 DNA replication and checkpoint protein FMO-like PF00743.19 CCF36764.1 - 0.041 12.3 0.0 0.059 11.8 0.0 1.1 1 0 0 1 1 1 0 Flavin-binding monooxygenase-like UPF0149 PF03695.13 CCF36764.1 - 0.048 14.0 0.5 0.097 13.0 0.5 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0149) Fungal_trans PF04082.18 CCF36765.1 - 1.9e-08 33.7 0.0 4.9e-08 32.3 0.0 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF36765.1 - 1.6e-07 31.3 14.9 2.7e-07 30.6 14.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF503 PF04456.12 CCF36765.1 - 0.14 12.0 0.2 0.33 10.8 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF503) CH PF00307.31 CCF36766.1 - 1.3e-67 224.8 0.0 1.5e-17 63.7 0.0 4.1 4 0 0 4 4 4 4 Calponin homology (CH) domain MBOAT PF03062.19 CCF36767.1 - 2e-44 152.4 25.4 5e-44 151.1 20.4 2.1 2 0 0 2 2 2 2 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.6 CCF36767.1 - 6.1e-06 26.4 5.4 1.5e-05 25.2 5.4 1.6 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family Peptidase_M20 PF01546.28 CCF36768.1 - 1.5e-30 106.5 0.0 2.1e-30 106.0 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 CCF36768.1 - 1.8e-08 34.2 0.0 3.9e-08 33.2 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 CCF36768.1 - 0.0041 16.8 0.0 0.0074 16.0 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 WG_beta_rep PF14903.6 CCF36768.1 - 0.0069 16.7 0.1 0.015 15.5 0.1 1.6 1 0 0 1 1 1 1 WG containing repeat Peptidase_M42 PF05343.14 CCF36768.1 - 0.07 12.1 0.0 0.72 8.8 0.0 2.3 3 0 0 3 3 3 0 M42 glutamyl aminopeptidase Sortilin-Vps10 PF15902.5 CCF36769.1 - 1.2e-11 44.1 0.4 0.00019 20.4 0.0 4.2 3 1 1 5 5 5 4 Sortilin, neurotensin receptor 3, CBM_1 PF00734.18 CCF36769.1 - 4.4e-11 42.5 5.5 1.3e-10 41.0 5.5 1.9 1 0 0 1 1 1 1 Fungal cellulose binding domain Kelch_3 PF13415.6 CCF36769.1 - 0.0062 16.8 0.2 0.0062 16.8 0.2 3.8 4 0 0 4 4 4 1 Galactose oxidase, central domain BNR PF02012.20 CCF36769.1 - 0.0063 16.3 29.6 1.4 9.2 0.1 8.8 7 0 0 7 7 7 3 BNR/Asp-box repeat BNR_6 PF15899.5 CCF36769.1 - 0.041 13.9 7.0 67 4.0 0.1 6.4 7 0 0 7 7 7 0 BNR-Asp box repeat Toxin_7 PF05980.12 CCF36769.1 - 0.42 10.9 1.3 0.76 10.1 1.3 1.4 1 0 0 1 1 1 0 Toxin 7 Mucin PF01456.17 CCF36769.1 - 3.9 7.5 18.6 0.44 10.5 13.5 2.0 2 0 0 2 2 2 0 Mucin-like glycoprotein SprA-related PF12118.8 CCF36769.1 - 4.9 6.2 10.6 8.9 5.3 10.6 1.4 1 0 0 1 1 1 0 SprA-related family Ank_2 PF12796.7 CCF36770.1 - 2.7e-58 194.5 0.0 1.6e-16 60.6 0.0 5.7 2 1 4 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CCF36770.1 - 2.3e-57 190.7 6.6 7.7e-12 45.5 0.0 7.1 2 2 5 7 7 7 7 Ankyrin repeats (many copies) Ank PF00023.30 CCF36770.1 - 4.5e-48 159.7 5.6 2.1e-07 31.1 0.0 9.3 9 0 0 9 9 9 8 Ankyrin repeat Ank_5 PF13857.6 CCF36770.1 - 1.3e-42 143.2 6.8 8.4e-10 38.7 0.1 9.2 1 1 8 9 9 9 9 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCF36770.1 - 5.8e-42 136.9 0.3 2.1e-07 30.7 0.0 9.7 9 0 0 9 9 9 7 Ankyrin repeat EthD PF07110.11 CCF36772.1 - 0.0021 19.2 0.0 0.0074 17.4 0.0 1.8 1 1 0 1 1 1 1 EthD domain DJ-1_PfpI PF01965.24 CCF36773.1 - 7.8e-08 32.3 0.0 2.5e-07 30.6 0.0 1.9 1 1 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.5 CCF36773.1 - 0.034 13.8 0.1 0.045 13.4 0.1 1.4 1 1 0 1 1 1 0 ThiJ/PfpI family-like Epimerase PF01370.21 CCF36774.1 - 2.9e-18 66.2 0.0 6.5e-18 65.1 0.0 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 CCF36774.1 - 4.3e-12 45.7 0.0 3.6e-10 39.5 0.0 2.1 1 1 0 1 1 1 1 Male sterility protein 3Beta_HSD PF01073.19 CCF36774.1 - 2.5e-11 43.1 0.0 4.2e-11 42.4 0.0 1.4 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 CCF36774.1 - 8.3e-11 41.9 0.0 1.4e-10 41.1 0.0 1.4 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 CCF36774.1 - 2.2e-06 27.7 0.1 4.9e-06 26.6 0.0 1.6 2 0 0 2 2 2 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 CCF36774.1 - 2.8e-06 26.7 0.0 3.6e-06 26.3 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NmrA PF05368.13 CCF36774.1 - 7.8e-05 22.3 0.1 0.0002 21.0 0.1 1.7 2 0 0 2 2 2 1 NmrA-like family KR PF08659.10 CCF36774.1 - 0.0015 18.5 0.1 0.0026 17.7 0.1 1.4 1 1 0 1 1 1 1 KR domain RmlD_sub_bind PF04321.17 CCF36774.1 - 0.013 14.6 0.1 0.036 13.2 0.1 1.6 2 0 0 2 2 2 0 RmlD substrate binding domain adh_short PF00106.25 CCF36774.1 - 0.028 13.9 0.1 0.063 12.7 0.1 1.6 1 0 0 1 1 1 0 short chain dehydrogenase NAD_binding_10 PF13460.6 CCF36775.1 - 2.4e-13 50.4 0.6 4.2e-13 49.6 0.6 1.4 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 CCF36775.1 - 6.1e-13 48.9 0.1 8.6e-13 48.4 0.1 1.2 1 0 0 1 1 1 1 NmrA-like family Sacchrp_dh_NADP PF03435.18 CCF36775.1 - 2.7e-10 40.6 0.1 4.8e-10 39.8 0.1 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain F420_oxidored PF03807.17 CCF36775.1 - 6.2e-06 26.7 0.1 1.3e-05 25.7 0.1 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent GFO_IDH_MocA PF01408.22 CCF36775.1 - 1.9e-05 25.5 0.0 3.4e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Epimerase PF01370.21 CCF36775.1 - 0.00019 21.0 0.1 0.00029 20.4 0.1 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 CCF36775.1 - 0.00019 21.9 0.1 0.00032 21.1 0.1 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.20 CCF36775.1 - 0.00084 19.5 0.0 0.0018 18.4 0.0 1.5 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus ApbA PF02558.16 CCF36775.1 - 0.0016 18.1 0.1 0.022 14.4 0.1 2.2 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA KR PF08659.10 CCF36775.1 - 0.0039 17.1 0.6 0.0091 15.9 0.6 1.7 1 1 0 1 1 1 1 KR domain adh_short PF00106.25 CCF36775.1 - 0.0063 16.0 0.1 0.013 15.0 0.1 1.6 1 0 0 1 1 1 1 short chain dehydrogenase Shikimate_DH PF01488.20 CCF36775.1 - 0.011 15.8 0.0 0.019 15.1 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Ldh_1_N PF00056.23 CCF36775.1 - 0.015 15.3 0.3 0.054 13.6 0.3 1.9 1 1 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain TrkA_N PF02254.18 CCF36775.1 - 0.024 14.9 0.1 0.068 13.4 0.1 1.8 1 1 0 1 1 1 0 TrkA-N domain 3Beta_HSD PF01073.19 CCF36775.1 - 0.04 12.9 0.0 0.063 12.3 0.0 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family THF_DHG_CYH_C PF02882.19 CCF36775.1 - 0.12 11.7 0.0 0.3 10.4 0.0 1.7 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DUF4538 PF15061.6 CCF36776.1 - 0.012 15.3 1.8 0.012 15.3 1.8 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4538) VEGFR-2_TMD PF17988.1 CCF36776.1 - 0.074 12.5 2.9 0.2 11.1 2.9 1.8 1 0 0 1 1 1 0 VEGFR-2 Transmembrane domain UL41A PF17591.2 CCF36776.1 - 1.8 8.7 5.7 0.35 11.0 1.2 2.2 2 0 0 2 2 2 0 Herpesvirus UL41A GCV_T PF01571.21 CCF36777.1 - 1.5e-64 217.8 0.0 3.2e-64 216.8 0.0 1.5 2 0 0 2 2 2 1 Aminomethyltransferase folate-binding domain DAO PF01266.24 CCF36777.1 - 2.9e-46 158.7 1.7 4.4e-46 158.1 1.7 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAO_M PF16350.5 CCF36777.1 - 3.8e-20 72.0 0.0 6.9e-20 71.1 0.0 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase central domain GCV_T_C PF08669.11 CCF36777.1 - 1.4e-18 66.6 0.1 3.8e-18 65.2 0.1 1.8 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain Pyr_redox_2 PF07992.14 CCF36777.1 - 3.6e-05 23.1 0.3 0.15 11.3 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCF36777.1 - 4.3e-05 24.0 0.6 0.052 14.1 0.2 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CCF36777.1 - 0.0011 18.2 0.2 0.004 16.3 0.2 1.9 2 0 0 2 2 2 1 FAD binding domain Trp_halogenase PF04820.14 CCF36777.1 - 0.0032 16.4 1.5 0.032 13.1 0.0 2.1 2 0 0 2 2 2 1 Tryptophan halogenase TrkA_N PF02254.18 CCF36777.1 - 0.0038 17.5 0.4 0.012 15.8 0.1 2.0 2 0 0 2 2 2 1 TrkA-N domain Shikimate_DH PF01488.20 CCF36777.1 - 0.0064 16.6 0.1 0.014 15.5 0.1 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase ThiF PF00899.21 CCF36777.1 - 0.0097 15.3 0.0 0.02 14.3 0.0 1.4 1 0 0 1 1 1 1 ThiF family NAD_binding_9 PF13454.6 CCF36777.1 - 0.079 13.0 1.5 0.66 9.9 0.1 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 CCF36777.1 - 0.12 12.6 0.0 0.33 11.2 0.0 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain F420_oxidored PF03807.17 CCF36777.1 - 0.14 12.8 0.2 0.93 10.1 0.1 2.4 3 0 0 3 3 2 0 NADP oxidoreductase coenzyme F420-dependent Sacchrp_dh_NADP PF03435.18 CCF36777.1 - 0.26 11.5 0.5 0.65 10.3 0.5 1.7 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain HET PF06985.11 CCF36781.1 - 3.2e-14 53.5 0.0 9.7e-14 51.9 0.0 1.8 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) UPF0029 PF01205.19 CCF36782.1 - 3.4e-33 114.1 0.0 6.8e-33 113.1 0.0 1.5 2 0 0 2 2 2 1 Uncharacterized protein family UPF0029 RWD PF05773.22 CCF36782.1 - 2.3e-06 27.9 0.0 1e-05 25.8 0.0 1.9 1 1 0 1 1 1 1 RWD domain Use1 PF09753.9 CCF36784.1 - 1e-12 48.3 5.0 7.3e-12 45.5 0.0 2.2 2 0 0 2 2 2 1 Membrane fusion protein Use1 GldM_N PF12081.8 CCF36784.1 - 0.045 13.9 2.7 0.049 13.7 1.0 1.8 2 0 0 2 2 2 0 GldM N-terminal domain Phage_Gp23 PF10669.9 CCF36784.1 - 2.2 8.6 8.8 8.3 6.8 0.3 3.4 2 2 1 3 3 3 0 Protein gp23 (Bacteriophage A118) NAD_binding_10 PF13460.6 CCF36785.1 - 8.5e-18 64.9 0.0 1.1e-17 64.6 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 CCF36785.1 - 0.11 12.1 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 NmrA-like family adh_short PF00106.25 CCF36786.1 - 5.3e-32 110.9 0.0 5.8e-24 84.6 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCF36786.1 - 5.1e-21 75.3 0.0 5e-16 59.0 0.0 2.0 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF36786.1 - 2.9e-09 37.1 0.0 4.2e-09 36.6 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF36786.1 - 0.0017 17.9 0.1 0.0026 17.2 0.1 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 CCF36786.1 - 0.0064 15.7 0.0 0.0088 15.2 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 CCF36786.1 - 0.0077 16.1 0.0 0.045 13.6 0.0 2.0 2 0 0 2 2 2 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 CCF36786.1 - 0.013 15.0 0.4 0.018 14.5 0.1 1.4 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 CCF36786.1 - 0.068 12.2 0.1 0.29 10.1 0.1 1.9 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Fungal_trans PF04082.18 CCF36788.1 - 1.7e-38 132.2 0.0 5.8e-38 130.5 0.0 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF36788.1 - 0.0029 17.7 1.3 0.005 16.9 1.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Crystall PF00030.19 CCF36789.1 - 0.14 12.4 0.1 0.19 12.0 0.1 1.2 1 0 0 1 1 1 0 Beta/Gamma crystallin Sugar_tr PF00083.24 CCF36790.1 - 4.7e-82 276.2 24.5 6.3e-82 275.8 24.5 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF36790.1 - 8.1e-29 100.6 26.3 8.1e-29 100.6 26.3 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 CCF36790.1 - 7.2e-07 28.0 2.7 1.5e-06 27.0 2.7 1.4 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF1761 PF08570.10 CCF36790.1 - 0.82 9.9 12.7 0.78 10.0 6.1 3.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1761) OPT PF03169.15 CCF36791.1 - 2.3e-29 102.5 0.6 2.9e-29 102.2 0.6 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Chs7 PF12271.8 CCF36792.1 - 1.6e-122 408.4 17.0 1.8e-122 408.2 17.0 1.0 1 0 0 1 1 1 1 Chitin synthase export chaperone DUF3382 PF11862.8 CCF36792.1 - 0.012 15.9 1.3 0.012 15.9 1.3 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF3382) Cyclin PF08613.11 CCF36794.1 - 2.6e-12 47.4 0.5 4.8e-12 46.5 0.5 1.5 1 1 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 CCF36794.1 - 0.00051 19.8 0.0 0.00083 19.1 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Ndc1_Nup PF09531.10 CCF36796.1 - 4.6 5.8 6.5 5.3 5.6 6.5 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF3021 PF11457.8 CCF36796.1 - 4.9 7.5 9.2 9.8 6.5 0.4 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3021) FATC PF02260.20 CCF36797.1 - 1.5e-13 50.3 0.1 1.9e-13 49.9 0.1 1.1 1 0 0 1 1 1 1 FATC domain Cullin PF00888.22 CCF36798.1 - 3.2e-178 594.2 0.1 4.1e-178 593.8 0.1 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 CCF36798.1 - 2.2e-24 85.2 0.3 6.4e-24 83.8 0.3 1.8 1 0 0 1 1 1 1 Cullin protein neddylation domain WHEP-TRS PF00458.20 CCF36798.1 - 0.062 13.5 0.2 2.6 8.3 0.0 2.8 2 0 0 2 2 2 0 WHEP-TRS domain Ribosomal_L10 PF00466.20 CCF36799.1 - 5.6e-22 77.8 0.0 7.6e-22 77.3 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L10 RL10P_insert PF17777.1 CCF36799.1 - 5.7e-20 71.1 0.0 9.3e-20 70.4 0.0 1.4 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P DUF4710 PF15828.5 CCF36799.1 - 0.06 13.5 0.2 0.098 12.8 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4710) Lactonase PF10282.9 CCF36801.1 - 6.2e-78 262.5 0.0 7.5e-78 262.2 0.0 1.0 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller Acetyltransf_3 PF13302.7 CCF36802.1 - 2.3e-11 44.5 0.1 4.8e-11 43.5 0.0 1.5 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CCF36802.1 - 5.8e-08 33.0 0.0 9.5e-08 32.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family SCA7 PF08313.12 CCF36803.1 - 6.3e-32 109.3 0.2 2.1e-31 107.6 0.2 1.9 1 0 0 1 1 1 1 SCA7, zinc-binding domain Nop53 PF07767.11 CCF36803.1 - 2.1 7.6 32.1 0.62 9.4 27.7 1.9 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) Glyco_hydro_70 PF02324.16 CCF36805.1 - 0.088 11.0 0.0 0.11 10.7 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 70 DUF2489 PF10675.9 CCF36806.1 - 0.025 14.5 0.0 0.058 13.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2489) Forkhead PF00250.18 CCF36808.1 - 1.7e-14 53.8 0.0 3.3e-14 52.9 0.0 1.4 1 0 0 1 1 1 1 Forkhead domain FHA PF00498.26 CCF36808.1 - 7.7e-06 26.2 0.1 1.5e-05 25.3 0.1 1.5 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 CCF36808.1 - 0.085 13.2 0.0 0.23 11.8 0.0 1.7 1 0 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain Di19_C PF14571.6 CCF36808.1 - 0.37 11.3 4.2 3.9 8.1 0.1 3.1 2 0 0 2 2 2 0 Stress-induced protein Di19, C-terminal CAP59_mtransfer PF11735.8 CCF36809.1 - 3.1e-38 131.8 0.1 3.8e-38 131.6 0.1 1.1 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 DUF4684 PF15736.5 CCF36810.1 - 0.011 14.5 2.3 0.012 14.4 2.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4684) DIE2_ALG10 PF04922.12 CCF36811.1 - 7.7 5.7 7.8 0.99 8.6 3.8 1.5 2 0 0 2 2 2 0 DIE2/ALG10 family TPR_1 PF00515.28 CCF36814.1 - 2.5e-37 125.2 13.1 2.1e-06 27.3 0.1 8.4 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_2 PF07719.17 CCF36814.1 - 1.3e-36 121.7 11.8 3.6e-06 26.7 0.0 8.4 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_11 PF13414.6 CCF36814.1 - 1.5e-28 98.2 12.0 6.8e-09 35.3 0.3 7.3 6 1 1 7 7 7 6 TPR repeat DnaJ PF00226.31 CCF36814.1 - 5.8e-27 93.6 4.3 5.8e-27 93.6 4.3 2.8 3 0 0 3 3 2 1 DnaJ domain TPR_16 PF13432.6 CCF36814.1 - 2.5e-22 79.2 2.3 3.1e-06 27.7 0.1 6.2 5 1 0 5 5 5 5 Tetratricopeptide repeat TPR_19 PF14559.6 CCF36814.1 - 4.2e-19 68.8 12.1 1.1e-05 25.8 0.1 6.1 3 2 2 5 5 5 4 Tetratricopeptide repeat TPR_17 PF13431.6 CCF36814.1 - 7.5e-15 54.2 11.9 0.00061 20.0 0.0 7.2 6 0 0 6 6 6 4 Tetratricopeptide repeat ANAPC3 PF12895.7 CCF36814.1 - 1.3e-14 54.2 7.6 1.9e-06 28.0 0.3 3.7 3 0 0 3 3 3 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 CCF36814.1 - 2.7e-14 53.2 13.8 0.029 14.7 0.3 6.6 4 2 2 6 6 6 4 Tetratricopeptide repeat TPR_8 PF13181.6 CCF36814.1 - 6.6e-13 47.8 18.5 0.0014 18.6 0.2 7.6 9 0 0 9 9 7 4 Tetratricopeptide repeat TPR_9 PF13371.6 CCF36814.1 - 1e-12 48.0 5.1 0.0092 16.1 0.1 5.0 3 2 2 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.6 CCF36814.1 - 1.9e-12 46.9 12.7 0.00028 21.4 0.0 7.6 7 2 1 8 8 6 2 Tetratricopeptide repeat TPR_7 PF13176.6 CCF36814.1 - 5.2e-10 38.6 8.8 0.35 11.0 0.0 7.6 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_6 PF13174.6 CCF36814.1 - 1.2e-06 28.7 17.7 0.085 13.5 0.0 8.3 9 1 1 10 10 7 1 Tetratricopeptide repeat TPR_10 PF13374.6 CCF36814.1 - 3.5e-05 23.5 11.0 0.28 11.1 0.0 6.1 6 1 1 7 7 6 1 Tetratricopeptide repeat NARP1 PF12569.8 CCF36814.1 - 0.00015 20.8 3.7 0.0012 17.9 0.5 2.8 2 1 0 2 2 2 1 NMDA receptor-regulated protein 1 TPR_4 PF07721.14 CCF36814.1 - 0.00022 21.5 2.5 0.13 13.0 0.0 4.9 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_15 PF13429.6 CCF36814.1 - 0.00047 19.5 9.3 0.18 11.0 0.0 4.2 2 2 2 4 4 4 2 Tetratricopeptide repeat ChAPs PF09295.10 CCF36814.1 - 0.0066 15.5 0.1 0.014 14.4 0.1 1.5 1 0 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) Alkyl_sulf_dimr PF14863.6 CCF36814.1 - 0.0069 16.8 2.5 5.3 7.5 0.0 4.3 3 2 1 4 4 4 1 Alkyl sulfatase dimerisation TPR_20 PF14561.6 CCF36814.1 - 0.014 15.7 11.3 0.93 9.9 0.2 5.0 3 2 2 5 5 5 0 Tetratricopeptide repeat DUF928 PF06051.12 CCF36814.1 - 0.063 13.1 0.2 0.14 12.0 0.2 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF928) PPR PF01535.20 CCF36814.1 - 0.064 13.5 0.2 27 5.3 0.0 3.6 4 0 0 4 4 2 0 PPR repeat RPT PF13446.6 CCF36814.1 - 0.097 12.6 0.1 0.77 9.7 0.0 2.6 2 0 0 2 2 1 0 A repeated domain in UCH-protein Coatomer_E PF04733.14 CCF36814.1 - 0.11 11.9 1.2 7.3 5.9 0.0 2.7 3 0 0 3 3 3 0 Coatomer epsilon subunit BTAD PF03704.17 CCF36814.1 - 0.32 11.4 10.4 24 5.3 0.1 4.9 3 2 3 6 6 5 0 Bacterial transcriptional activator domain DUF357 PF04010.13 CCF36814.1 - 4.7 7.4 5.4 3.7 7.7 0.3 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF357) EF-hand_6 PF13405.6 CCF36815.1 - 2.4e-12 45.7 0.3 3.2e-06 26.6 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 CCF36815.1 - 1.1e-10 40.2 2.6 5.1e-05 22.5 0.2 2.4 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 CCF36815.1 - 1.9e-08 34.6 4.0 8.6e-06 26.1 1.0 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 CCF36815.1 - 4.1e-07 29.8 0.7 0.0012 18.6 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 CCF36815.1 - 3e-06 26.5 5.4 0.0022 17.4 0.8 2.3 2 0 0 2 2 2 2 EF hand EF-hand_9 PF14658.6 CCF36815.1 - 0.018 15.4 0.0 6.7 7.1 0.0 2.3 2 0 0 2 2 2 0 EF-hand domain ORC6 PF05460.13 CCF36815.1 - 2 7.6 7.1 4.6 6.4 7.1 1.6 1 1 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Afi1 PF07792.12 CCF36816.1 - 3.5e-47 160.2 0.5 5.7e-47 159.5 0.5 1.4 1 0 0 1 1 1 1 Docking domain of Afi1 for Arf3 in vesicle trafficking SPA PF08616.10 CCF36816.1 - 5.9e-36 122.9 0.0 1e-35 122.1 0.0 1.4 1 0 0 1 1 1 1 Stabilization of polarity axis Avl9 PF09794.9 CCF36816.1 - 1.6e-07 30.4 0.0 0.011 14.4 0.0 3.8 3 1 1 4 4 4 2 Transport protein Avl9 Cwf_Cwc_15 PF04889.12 CCF36816.1 - 0.0016 18.2 5.7 0.0029 17.4 5.7 1.3 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein DUF2347 PF09804.9 CCF36816.1 - 0.071 12.7 0.0 0.26 10.8 0.0 2.0 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) Astro_capsid_p PF12226.8 CCF36816.1 - 2.8 7.0 4.7 4.6 6.3 4.7 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Esterase PF00756.20 CCF36817.1 - 1.1e-51 176.0 0.0 1.3e-51 175.7 0.0 1.0 1 0 0 1 1 1 1 Putative esterase Esterase_phd PF10503.9 CCF36817.1 - 2e-05 24.2 0.1 0.00015 21.3 0.1 2.0 1 1 0 1 1 1 1 Esterase PHB depolymerase Chlorophyllase2 PF12740.7 CCF36817.1 - 0.0023 16.9 0.0 0.0038 16.2 0.0 1.4 1 1 0 1 1 1 1 Chlorophyllase enzyme Hydrolase_4 PF12146.8 CCF36817.1 - 0.0041 16.4 0.0 0.0062 15.8 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 CCF36817.1 - 0.0041 16.6 0.0 0.0083 15.6 0.0 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 CCF36817.1 - 0.0083 16.7 0.0 0.01 16.4 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 CCF36817.1 - 0.024 14.5 0.0 0.037 13.8 0.0 1.3 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Chlorophyllase PF07224.11 CCF36817.1 - 0.078 12.0 0.0 0.19 10.7 0.0 1.6 2 0 0 2 2 2 0 Chlorophyllase PAF-AH_p_II PF03403.13 CCF36817.1 - 0.09 11.3 0.0 0.14 10.7 0.0 1.2 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II Lipase_3 PF01764.25 CCF36817.1 - 0.14 12.0 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) NAD_binding_4 PF07993.12 CCF36818.1 - 3.4e-30 105.1 0.0 5.5e-30 104.4 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein HTH_51 PF18558.1 CCF36818.1 - 7.5e-16 57.8 0.0 1.7e-15 56.7 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain Methyltransf_12 PF08242.12 CCF36818.1 - 7e-11 42.8 0.0 1.7e-10 41.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF36818.1 - 1.1e-09 38.8 0.0 3.8e-09 37.1 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF36818.1 - 1.1e-08 35.6 0.0 5.2e-08 33.4 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF36818.1 - 5.3e-07 29.6 0.0 3.2e-06 27.1 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF36818.1 - 5.7e-06 26.2 0.0 1.1e-05 25.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Epimerase PF01370.21 CCF36818.1 - 2.1e-05 24.1 0.0 3.6e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 CCF36818.1 - 0.0027 16.9 0.0 0.016 14.3 0.0 2.1 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein KR PF08659.10 CCF36818.1 - 0.0072 16.3 0.0 0.017 15.0 0.0 1.6 1 0 0 1 1 1 1 KR domain NodS PF05401.11 CCF36818.1 - 0.028 14.0 0.0 0.21 11.2 0.0 2.1 2 0 0 2 2 2 0 Nodulation protein S (NodS) Cnl2_NKP2 PF09447.10 CCF36818.1 - 0.047 13.9 0.3 0.12 12.5 0.3 1.7 1 1 0 1 1 1 0 Cnl2/NKP2 family protein DXP_reductoisom PF02670.16 CCF36818.1 - 0.069 13.9 0.0 0.14 12.8 0.0 1.5 1 0 0 1 1 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase Ubie_methyltran PF01209.18 CCF36818.1 - 0.11 11.9 0.0 1.9 7.7 0.0 2.2 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family adh_short_C2 PF13561.6 CCF36819.1 - 3.8e-34 118.3 0.0 1.2e-33 116.6 0.0 1.7 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF36819.1 - 4.1e-31 108.0 0.1 1.3e-30 106.3 0.1 1.7 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF36819.1 - 1.5e-07 31.5 0.1 5.6e-07 29.7 0.1 1.7 1 1 0 1 1 1 1 KR domain IlvN PF07991.12 CCF36819.1 - 0.055 13.0 0.1 0.076 12.6 0.1 1.2 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain CHB_HEX_C_1 PF13290.6 CCF36819.1 - 0.081 12.9 0.0 0.18 11.8 0.0 1.6 1 0 0 1 1 1 0 Chitobiase/beta-hexosaminidase C-terminal domain Cullin_binding PF03556.15 CCF36820.1 - 0.047 14.1 0.5 0.058 13.8 0.4 1.4 1 1 0 1 1 1 0 Cullin binding Peptidase_M43 PF05572.13 CCF36821.1 - 1.1e-09 38.4 0.1 2.1e-09 37.5 0.1 1.4 1 0 0 1 1 1 1 Pregnancy-associated plasma protein-A Reprolysin_5 PF13688.6 CCF36821.1 - 0.053 13.7 0.0 0.1 12.7 0.0 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12 Clr5 PF14420.6 CCF36823.1 - 1.9e-14 53.6 0.1 2.8e-14 53.1 0.1 1.2 1 0 0 1 1 1 1 Clr5 domain DUF3669 PF12417.8 CCF36825.1 - 6.7e-23 80.7 0.1 1.3e-22 79.8 0.1 1.5 1 0 0 1 1 1 1 Zinc finger protein p450 PF00067.22 CCF36826.1 - 4e-17 62.1 0.0 8.8e-17 61.0 0.0 1.4 1 1 0 1 1 1 1 Cytochrome P450 FlxA PF14282.6 CCF36827.1 - 0.019 15.0 1.1 0.022 14.8 1.1 1.3 1 0 0 1 1 1 0 FlxA-like protein DivIC PF04977.15 CCF36827.1 - 0.051 13.3 2.0 0.089 12.6 2.0 1.4 1 0 0 1 1 1 0 Septum formation initiator Fzo_mitofusin PF04799.13 CCF36827.1 - 0.052 13.1 0.5 0.066 12.8 0.5 1.2 1 0 0 1 1 1 0 fzo-like conserved region Sipho_Gp157 PF05565.11 CCF36827.1 - 0.064 13.3 0.2 0.075 13.0 0.2 1.1 1 0 0 1 1 1 0 Siphovirus Gp157 DUF3450 PF11932.8 CCF36827.1 - 0.071 12.4 1.8 0.081 12.2 1.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) K_trans PF02705.16 CCF36828.1 - 1.2e-183 611.5 15.8 1.4e-183 611.3 15.8 1.0 1 0 0 1 1 1 1 K+ potassium transporter GTP_EFTU PF00009.27 CCF36829.1 - 1.1e-45 155.6 0.0 2.8e-45 154.3 0.0 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.6 CCF36829.1 - 4.1e-23 81.3 0.0 2.8e-22 78.6 0.0 2.2 2 0 0 2 2 2 1 Elongation Factor G, domain II EFG_C PF00679.24 CCF36829.1 - 9.3e-12 44.8 0.0 0.00011 22.1 0.0 2.9 3 0 0 3 3 3 2 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 CCF36829.1 - 1.3e-05 25.5 0.0 3.3e-05 24.2 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_IV PF03764.18 CCF36829.1 - 0.00018 21.3 0.0 0.00051 19.8 0.0 1.9 1 1 0 1 1 1 1 Elongation factor G, domain IV RF3_C PF16658.5 CCF36829.1 - 0.00029 20.7 0.0 0.014 15.2 0.0 2.5 2 0 0 2 2 2 1 Class II release factor RF3, C-terminal domain zf-C3HC4_3 PF13920.6 CCF36831.1 - 2.7e-11 43.1 7.8 4.1e-11 42.6 7.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CCF36831.1 - 1.5e-08 34.3 10.3 3e-08 33.3 10.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CCF36831.1 - 3.8e-08 33.0 8.6 6.8e-08 32.3 8.6 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 CCF36831.1 - 1.2e-07 31.9 9.0 2.1e-07 31.2 9.0 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 CCF36831.1 - 3.2e-07 30.2 9.4 5.3e-07 29.5 9.4 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 CCF36831.1 - 4.2e-07 29.7 9.8 6.7e-07 29.1 9.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CCF36831.1 - 6.9e-07 29.2 3.2 6.9e-07 29.2 3.2 2.2 1 1 1 2 2 2 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 CCF36831.1 - 1.5e-05 25.0 3.5 2.8e-05 24.1 3.5 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.6 CCF36831.1 - 0.00047 19.9 5.4 0.00089 19.0 5.4 1.5 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.7 CCF36831.1 - 0.002 18.4 5.5 0.0052 17.1 5.5 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 CCF36831.1 - 0.011 15.8 7.9 0.02 15.1 7.9 1.4 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING TerY_C PF15616.6 CCF36831.1 - 0.049 13.7 1.5 0.088 12.9 1.5 1.3 1 0 0 1 1 1 0 TerY-C metal binding domain zf-RING_11 PF17123.5 CCF36831.1 - 0.051 13.3 9.8 0.16 11.7 7.0 2.4 2 0 0 2 2 2 0 RING-like zinc finger zf-RING_6 PF14835.6 CCF36831.1 - 0.26 11.2 2.9 0.47 10.4 2.9 1.3 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-P11 PF03854.14 CCF36831.1 - 0.88 9.3 5.0 1.7 8.4 5.0 1.4 1 0 0 1 1 1 0 P-11 zinc finger DZR PF12773.7 CCF36831.1 - 2.6 8.1 6.2 6.7 6.8 6.2 1.7 1 1 0 1 1 1 0 Double zinc ribbon PI-PLC-Y PF00387.19 CCF36833.1 - 8e-27 93.9 0.0 1.2e-26 93.3 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.30 CCF36833.1 - 8.9e-05 22.7 0.0 0.00023 21.4 0.0 1.7 1 1 0 1 1 1 1 C2 domain Glyco_hydro_28 PF00295.17 CCF36834.1 - 1.4e-49 168.9 3.9 2e-49 168.4 3.9 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 CBM60 PF16841.5 CCF36834.1 - 0.15 12.5 0.2 1.1 9.7 0.2 2.4 2 0 0 2 2 2 0 Ca-dependent carbohydrate-binding module xylan-binding VIT PF08487.10 CCF36836.1 - 9.6e-31 106.3 0.1 1.6e-30 105.5 0.1 1.4 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA_3 PF13768.6 CCF36836.1 - 2.8e-23 82.6 0.0 1.6e-22 80.2 0.0 2.1 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_2 PF13519.6 CCF36836.1 - 1.1e-14 55.0 0.0 2.5e-14 53.8 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 CCF36836.1 - 2.7e-12 47.3 0.0 4.9e-12 46.4 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VIT_2 PF13757.6 CCF36836.1 - 1.1e-07 31.6 0.0 2.2e-07 30.7 0.0 1.4 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain vWA-TerF-like PF10138.9 CCF36836.1 - 0.0042 17.2 0.0 0.0073 16.4 0.0 1.3 1 0 0 1 1 1 1 vWA found in TerF C terminus VWA_CoxE PF05762.14 CCF36836.1 - 0.033 13.6 0.0 5.3 6.4 0.0 2.2 2 0 0 2 2 2 0 VWA domain containing CoxE-like protein SID-1_RNA_chan PF13965.6 CCF36839.1 - 0.062 11.7 0.0 0.066 11.6 0.0 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF2826 PF11442.8 CCF36840.1 - 0.39 10.5 2.3 14 5.5 0.0 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2826) Mog1 PF04603.12 CCF36841.1 - 3.1e-37 128.0 0.0 3.7e-37 127.8 0.0 1.1 1 0 0 1 1 1 1 Ran-interacting Mog1 protein SprT-like PF10263.9 CCF36842.1 - 7.5e-38 128.9 0.4 2.4e-37 127.2 0.4 1.9 1 0 0 1 1 1 1 SprT-like family Zn_ribbon_SprT PF17283.2 CCF36842.1 - 6.9e-10 38.7 4.5 1.4e-09 37.7 4.5 1.5 1 0 0 1 1 1 1 SprT-like zinc ribbon domain HMG_box PF00505.19 CCF36842.1 - 0.00029 21.2 0.2 0.00029 21.2 0.2 2.1 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 CCF36842.1 - 0.038 14.6 0.2 0.11 13.1 0.2 1.8 1 0 0 1 1 1 0 HMG-box domain Zn-ribbon_8 PF09723.10 CCF36842.1 - 0.062 13.4 1.4 0.15 12.2 1.4 1.7 1 0 0 1 1 1 0 Zinc ribbon domain YABBY PF04690.13 CCF36842.1 - 0.073 13.6 2.2 0.32 11.6 2.2 2.0 1 1 0 1 1 1 0 YABBY protein Peptidase_M90 PF06167.12 CCF36842.1 - 0.073 12.7 0.1 0.16 11.5 0.1 1.5 1 0 0 1 1 1 0 Glucose-regulated metallo-peptidase M90 DUF4379 PF14311.6 CCF36842.1 - 0.98 9.8 8.3 0.54 10.7 4.4 2.6 2 0 0 2 2 2 0 Probable Zinc-ribbon domain HalOD2 PF18547.1 CCF36842.1 - 0.98 9.4 3.4 0.5 10.3 0.6 2.0 2 0 0 2 2 2 0 Halobacterial output domain 2 Porin_3 PF01459.22 CCF36844.1 - 1.9e-68 230.9 11.9 2.1e-68 230.7 11.9 1.0 1 0 0 1 1 1 1 Eukaryotic porin OMP_b-brl PF13505.6 CCF36844.1 - 0.84 9.7 14.3 0.42 10.7 10.9 2.2 1 1 0 2 2 2 0 Outer membrane protein beta-barrel domain Asn_synthase PF00733.21 CCF36845.1 - 8.3e-94 315.2 0.1 6e-55 187.3 0.0 2.1 1 1 1 2 2 2 2 Asparagine synthase GATase_7 PF13537.6 CCF36845.1 - 1.8e-39 134.4 0.0 2.9e-39 133.8 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 CCF36845.1 - 6.9e-30 104.0 0.0 1.3e-29 103.1 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.8 CCF36845.1 - 9.7e-09 35.0 0.0 1.8e-08 34.2 0.0 1.3 1 0 0 1 1 1 1 Aluminium induced protein NAD_synthase PF02540.17 CCF36845.1 - 0.0011 18.2 0.0 0.0034 16.5 0.0 1.8 1 1 0 1 1 1 1 NAD synthase AA_permease PF00324.21 CCF36847.1 - 5.9e-93 312.1 33.0 7.3e-93 311.7 33.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CCF36847.1 - 3.3e-25 88.8 33.7 4.1e-25 88.5 33.7 1.0 1 0 0 1 1 1 1 Amino acid permease DUF4389 PF14333.6 CCF36847.1 - 0.5 10.3 9.5 5.7 6.9 0.6 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4389) zf-C2H2_3 PF13878.6 CCF36850.1 - 2.2e-08 33.8 0.7 2.3e-08 33.7 0.7 1.1 1 0 0 1 1 1 1 zinc-finger of acetyl-transferase ESCO Vma12 PF11712.8 CCF36851.1 - 3.5e-42 143.8 0.0 5e-42 143.3 0.0 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum-based factor for assembly of V-ATPase DUF1772 PF08592.11 CCF36851.1 - 0.023 15.0 0.4 0.037 14.4 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1772) polyprenyl_synt PF00348.17 CCF36852.1 - 6.6e-74 248.2 0.0 9.7e-74 247.6 0.0 1.2 1 0 0 1 1 1 1 Polyprenyl synthetase HEPPP_synt_1 PF07307.11 CCF36852.1 - 0.014 15.0 0.0 0.022 14.4 0.0 1.2 1 0 0 1 1 1 0 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1 MFS_1 PF07690.16 CCF36855.1 - 7.8e-19 67.8 65.4 4.8e-11 42.2 33.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 CCF36855.1 - 0.0018 16.9 10.9 0.0018 16.9 10.9 2.7 3 0 0 3 3 3 2 MFS/sugar transport protein Peptidase_M43 PF05572.13 CCF36856.1 - 9.5e-11 41.8 0.4 2.2e-10 40.6 0.4 1.7 1 1 0 1 1 1 1 Pregnancy-associated plasma protein-A Reprolysin_5 PF13688.6 CCF36856.1 - 7.5e-05 23.0 0.3 0.00018 21.7 0.3 1.6 1 1 0 1 1 1 1 Metallo-peptidase family M12 Astacin PF01400.24 CCF36856.1 - 0.0031 17.2 0.0 0.0062 16.2 0.0 1.4 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) Reprolysin_3 PF13582.6 CCF36856.1 - 0.017 15.7 0.8 0.025 15.1 0.2 1.7 2 1 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.24 CCF36856.1 - 0.062 13.1 0.1 0.1 12.4 0.1 1.3 1 0 0 1 1 1 0 Matrixin Reprolysin_2 PF13574.6 CCF36856.1 - 0.12 12.3 0.7 0.28 11.0 0.2 1.9 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 CCF36856.1 - 0.13 11.9 0.0 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like PI3_PI4_kinase PF00454.27 CCF36857.1 - 1.3e-32 113.6 0.0 5.8e-32 111.5 0.0 1.9 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase Pik1 PF11522.8 CCF36857.1 - 1.8e-19 69.4 0.0 3.6e-19 68.5 0.0 1.6 1 0 0 1 1 1 1 Yeast phosphatidylinositol-4-OH kinase Pik1 DUF4135 PF13575.6 CCF36857.1 - 0.033 13.5 0.0 0.057 12.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) CXCR4_N PF12109.8 CCF36857.1 - 0.15 12.3 0.1 0.37 11.0 0.1 1.6 1 0 0 1 1 1 0 CXCR4 Chemokine receptor N terminal PI3Ka PF00613.20 CCF36857.1 - 0.16 11.3 0.5 0.3 10.5 0.5 1.4 1 0 0 1 1 1 0 Phosphoinositide 3-kinase family, accessory domain (PIK domain) Acetyltransf_1 PF00583.25 CCF36858.1 - 4.7e-06 26.8 0.0 6.5e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CCF36858.1 - 0.019 15.4 0.0 0.027 14.9 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Hexokinase_1 PF00349.21 CCF36859.1 - 3.2e-76 255.7 0.0 4.5e-76 255.2 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_2 PF03727.16 CCF36859.1 - 5.5e-76 255.2 0.0 7.4e-76 254.7 0.0 1.2 1 0 0 1 1 1 1 Hexokinase DUF4574 PF15141.6 CCF36859.1 - 0.082 12.8 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 Ubiquinol-cytochrome-c reductase complex assembly factor 3 p450 PF00067.22 CCF36860.1 - 8.2e-10 38.0 0.0 1e-09 37.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Abhydrolase_6 PF12697.7 CCF36861.1 - 1.7e-22 81.1 1.5 1.7e-22 81.1 1.5 1.7 2 0 0 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCF36861.1 - 1.6e-07 30.9 0.0 2.5e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CCF36861.1 - 1.2e-06 28.3 0.6 0.011 15.4 0.3 3.0 2 1 0 2 2 2 2 alpha/beta hydrolase fold Thioesterase PF00975.20 CCF36861.1 - 0.0045 17.1 0.0 0.0084 16.2 0.0 1.4 1 0 0 1 1 1 1 Thioesterase domain PGAP1 PF07819.13 CCF36861.1 - 0.045 13.5 0.0 0.069 12.9 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein Abhydrolase_5 PF12695.7 CCF36861.1 - 0.093 12.5 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family TRP PF06011.12 CCF36862.1 - 7.8e-75 252.2 2.0 9.7e-75 251.9 2.0 1.0 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel zf-C2H2_11 PF16622.5 CCF36864.1 - 0.043 13.6 0.1 0.12 12.1 0.1 1.8 1 0 0 1 1 1 0 zinc-finger C2H2-type 2OG-FeII_Oxy_3 PF13640.6 CCF36865.1 - 1.4e-09 38.7 0.0 1.9e-09 38.3 0.0 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Methyltransf_23 PF13489.6 CCF36866.1 - 6.8e-21 74.8 0.0 1.1e-20 74.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF36866.1 - 2.9e-11 43.9 0.0 7.2e-11 42.6 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF36866.1 - 5.2e-10 39.3 0.0 2.1e-09 37.3 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF36866.1 - 3.2e-08 34.1 0.0 6.1e-08 33.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF36866.1 - 1.4e-07 32.2 0.0 1.6e-06 28.7 0.0 2.6 2 1 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 CCF36866.1 - 0.00022 20.8 0.0 0.00035 20.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_2 PF00891.18 CCF36866.1 - 0.00031 20.1 0.0 0.001 18.4 0.0 1.8 2 0 0 2 2 2 1 O-methyltransferase domain PrmA PF06325.13 CCF36866.1 - 0.01 15.2 0.0 0.015 14.7 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) FtsJ PF01728.19 CCF36866.1 - 0.041 14.0 0.0 0.066 13.3 0.0 1.2 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_4 PF02390.17 CCF36866.1 - 0.088 12.3 0.0 0.21 11.0 0.0 1.6 1 0 0 1 1 1 0 Putative methyltransferase CMAS PF02353.20 CCF36866.1 - 0.11 11.8 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_16 PF10294.9 CCF36866.1 - 0.16 11.7 0.0 0.27 11.0 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase Bystin PF05291.11 CCF36868.1 - 5.6e-126 419.7 0.0 7.3e-126 419.4 0.0 1.1 1 0 0 1 1 1 1 Bystin DUF383 PF04063.14 CCF36869.1 - 2.1e-66 223.3 0.3 6.8e-65 218.3 0.1 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF383) DUF384 PF04064.13 CCF36869.1 - 3.3e-22 78.1 0.4 8.9e-22 76.7 0.4 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF384) NTP_transf_9 PF04248.12 CCF36870.1 - 2.3e-33 113.9 1.5 2.7e-33 113.7 1.5 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF427) RSN1_7TM PF02714.15 CCF36871.1 - 8.4e-79 264.7 19.2 8.4e-79 264.7 19.2 2.1 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 CCF36871.1 - 2.5e-41 141.0 0.1 2.5e-41 141.0 0.1 2.7 3 0 0 3 3 3 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 CCF36871.1 - 3.4e-26 92.5 2.4 2.3e-15 57.3 0.2 2.4 2 0 0 2 2 2 2 Cytosolic domain of 10TM putative phosphate transporter PHM7_ext PF12621.8 CCF36871.1 - 5.4e-16 58.5 0.0 1.5e-15 57.2 0.0 1.7 1 0 0 1 1 1 1 Extracellular tail, of 10TM putative phosphate transporter FAD_binding_3 PF01494.19 CCF36872.1 - 4e-11 42.8 0.0 4.4e-11 42.6 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 CCF36872.1 - 1.4e-07 31.7 0.3 3.3e-07 30.4 0.3 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CCF36872.1 - 0.001 18.4 0.0 0.0023 17.2 0.1 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCF36872.1 - 0.001 18.7 1.8 0.0027 17.3 1.7 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CCF36872.1 - 0.0012 18.1 0.8 0.0021 17.2 0.8 1.4 1 0 0 1 1 1 1 FAD binding domain ThiF PF00899.21 CCF36872.1 - 0.011 15.1 0.1 0.021 14.2 0.1 1.5 2 0 0 2 2 2 0 ThiF family Pyr_redox_3 PF13738.6 CCF36872.1 - 0.042 13.1 0.3 0.069 12.4 0.3 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CCF36872.1 - 0.062 12.4 1.1 0.085 11.9 1.1 1.1 1 0 0 1 1 1 0 Glucose inhibited division protein A Thi4 PF01946.17 CCF36872.1 - 0.075 12.3 0.0 0.13 11.5 0.0 1.4 1 0 0 1 1 1 0 Thi4 family HI0933_like PF03486.14 CCF36872.1 - 0.13 11.0 0.5 0.18 10.5 0.5 1.1 1 0 0 1 1 1 0 HI0933-like protein 3HCDH_N PF02737.18 CCF36872.1 - 0.27 11.1 1.1 0.43 10.4 1.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NCE101 PF11654.8 CCF36873.1 - 0.13 12.0 0.0 0.27 11.0 0.0 1.6 1 0 0 1 1 1 0 Non-classical export protein 1 TMEM154 PF15102.6 CCF36874.1 - 0.0016 18.3 0.0 0.003 17.5 0.0 1.4 1 0 0 1 1 1 1 TMEM154 protein family DUF4448 PF14610.6 CCF36874.1 - 0.039 13.7 0.0 0.056 13.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) EphA2_TM PF14575.6 CCF36874.1 - 0.34 11.8 0.2 0.34 11.8 0.2 1.6 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain ALAD PF00490.21 CCF36875.1 - 2.5e-121 404.7 0.0 3e-121 404.5 0.0 1.1 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase Inhibitor_I9 PF05922.16 CCF36877.1 - 6.5e-09 36.3 0.1 8.7e-09 35.9 0.1 1.1 1 0 0 1 1 1 1 Peptidase inhibitor I9 YlbD_coat PF14071.6 CCF36879.1 - 0.039 14.2 0.0 0.05 13.8 0.0 1.2 1 0 0 1 1 1 0 Putative coat protein Amidohydro_1 PF01979.20 CCF36879.1 - 0.044 13.1 0.0 0.048 13.0 0.0 1.1 1 0 0 1 1 1 0 Amidohydrolase family Citrate_synt PF00285.21 CCF36882.1 - 1.8e-21 76.6 0.0 2.1e-18 66.5 0.0 2.8 1 1 1 2 2 2 2 Citrate synthase, C-terminal domain CoA_binding PF02629.19 CCF36882.1 - 7.4e-19 68.2 0.0 2.5e-18 66.6 0.0 1.9 2 0 0 2 2 2 1 CoA binding domain Ligase_CoA PF00549.19 CCF36882.1 - 3.9e-14 52.7 0.1 6.3e-14 52.1 0.1 1.3 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.6 CCF36882.1 - 3.4e-05 23.7 0.0 0.00029 20.7 0.0 2.2 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain RdRP PF05183.12 CCF36884.1 - 4.5e-133 445.0 0.0 6.1e-133 444.5 0.0 1.1 1 0 0 1 1 1 1 RNA dependent RNA polymerase Syntaxin-6_N PF09177.11 CCF36884.1 - 0.16 12.5 0.4 0.53 10.9 0.4 1.9 1 0 0 1 1 1 0 Syntaxin 6, N-terminal MFS_1 PF07690.16 CCF36887.1 - 1.4e-21 76.8 7.3 1.4e-21 76.8 7.3 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily Sensor PF13796.6 CCF36887.1 - 0.00011 22.2 8.9 0.00057 20.0 8.9 2.1 1 1 0 1 1 1 1 Putative sensor CSTF2_hinge PF14327.6 CCF36888.1 - 2.2e-33 114.5 2.4 4.1e-33 113.7 2.4 1.5 1 0 0 1 1 1 1 Hinge domain of cleavage stimulation factor subunit 2 RRM_1 PF00076.22 CCF36888.1 - 3.1e-22 78.2 0.0 5.2e-22 77.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CSTF_C PF14304.6 CCF36888.1 - 8.5e-11 41.3 1.2 8.5e-11 41.3 1.2 3.2 4 0 0 4 4 4 1 Transcription termination and cleavage factor C-terminal Spo7_2_N PF15407.6 CCF36888.1 - 0.055 13.1 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Sporulation protein family 7 RRM_7 PF16367.5 CCF36888.1 - 0.065 13.4 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif RRM_occluded PF16842.5 CCF36888.1 - 0.15 11.9 0.0 0.37 10.7 0.0 1.6 1 1 0 1 1 1 0 Occluded RNA-recognition motif COPIIcoated_ERV PF07970.12 CCF36889.1 - 2.7e-90 302.0 0.3 4.9e-90 301.2 0.2 1.5 2 0 0 2 2 2 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 CCF36889.1 - 2.5e-30 104.7 0.1 1.1e-29 102.6 0.0 2.0 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Steroid_dh PF02544.16 CCF36891.1 - 3.1e-32 111.6 0.6 4.3e-32 111.2 0.6 1.2 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.12 CCF36891.1 - 0.0002 21.0 1.7 0.0013 18.3 0.6 2.1 1 1 1 2 2 2 1 Protein of unknown function (DUF1295) PEMT PF04191.13 CCF36891.1 - 0.039 14.3 0.2 0.27 11.7 0.1 2.2 2 0 0 2 2 2 0 Phospholipid methyltransferase GCN5L1 PF06320.13 CCF36892.1 - 7e-20 71.3 0.3 1e-19 70.7 0.3 1.2 1 0 0 1 1 1 1 GCN5-like protein 1 (GCN5L1) PRCC PF10253.9 CCF36892.1 - 0.025 15.4 6.2 0.037 14.8 6.2 1.1 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting TFIIA PF03153.13 CCF36892.1 - 0.092 12.7 2.2 0.097 12.7 2.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FeoB_associated PF12669.7 CCF36892.1 - 0.29 11.6 2.2 0.51 10.8 2.2 1.3 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein DUF1979 PF09322.10 CCF36892.1 - 0.51 10.3 1.7 19 5.2 0.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1979) Fungal_trans PF04082.18 CCF36892.1 - 0.71 8.8 2.1 1 8.4 2.1 1.2 1 0 0 1 1 1 0 Fungal specific transcription factor domain DUF1993 PF09351.10 CCF36893.1 - 4.8e-53 179.6 0.0 5.5e-53 179.4 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1993) DinB PF05163.12 CCF36893.1 - 0.059 13.3 0.0 0.081 12.9 0.0 1.3 1 1 0 1 1 1 0 DinB family SOG2 PF10428.9 CCF36894.1 - 1e-81 275.7 11.5 3.6e-53 181.5 0.0 3.6 3 1 1 4 4 4 2 RAM signalling pathway protein LRR_8 PF13855.6 CCF36894.1 - 3.3e-17 62.0 0.6 1.1e-08 34.6 0.0 2.6 2 0 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 CCF36894.1 - 3.9e-14 52.5 2.7 1.5e-05 25.3 0.4 3.7 2 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 CCF36894.1 - 0.011 16.2 4.3 8.8 7.3 0.1 4.5 4 0 0 4 4 4 0 Leucine Rich Repeat LRR_6 PF13516.6 CCF36894.1 - 0.013 15.5 4.7 1.7 8.9 0.1 4.1 3 0 0 3 3 3 0 Leucine Rich repeat DUF2408 PF10303.9 CCF36894.1 - 0.04 14.5 0.0 0.33 11.5 0.0 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2408) MAP17 PF15807.5 CCF36895.1 - 0.13 12.5 0.0 0.13 12.5 0.0 1.0 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 NigD_N PF12667.7 CCF36896.1 - 0.0078 16.3 0.0 0.013 15.6 0.0 1.3 1 0 0 1 1 1 1 NigD-like N-terminal OB domain TMEM51 PF15345.6 CCF36896.1 - 0.0097 15.8 0.0 0.011 15.7 0.0 1.2 1 0 0 1 1 1 1 Transmembrane protein 51 SRTM1 PF15872.5 CCF36896.1 - 0.013 15.6 0.0 0.014 15.5 0.0 1.1 1 0 0 1 1 1 0 Serine-rich and transmembrane domain-containing protein 1 DUF3357 PF11837.8 CCF36896.1 - 0.016 15.7 0.1 0.018 15.5 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) zf-CCHC PF00098.23 CCF36900.1 - 0.01 15.9 2.3 0.01 15.9 2.3 5.5 5 0 0 5 5 5 0 Zinc knuckle IPU_b_solenoid PF18783.1 CCF36901.1 - 0.19 11.8 0.1 0.54 10.3 0.0 1.7 2 0 0 2 2 2 0 Isopullulanase beta-solenoid repeat Ank_3 PF13606.6 CCF36902.1 - 1.7e-08 34.0 0.0 0.0067 16.8 0.0 3.7 3 1 0 3 3 3 2 Ankyrin repeat Ank_2 PF12796.7 CCF36902.1 - 2.8e-07 31.0 0.0 8.8e-07 29.4 0.0 1.9 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CCF36902.1 - 9.8e-07 29.2 0.0 3.2e-05 24.4 0.0 2.8 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 CCF36902.1 - 7.2e-06 26.2 0.2 4.3 7.8 0.0 4.5 4 1 1 5 5 5 3 Ankyrin repeats (many copies) Ank PF00023.30 CCF36902.1 - 0.00012 22.4 0.0 0.63 10.6 0.0 3.1 3 0 0 3 3 3 2 Ankyrin repeat TFIIS_C PF01096.18 CCF36903.1 - 5.9e-21 74.0 3.2 5.9e-21 74.0 3.2 2.7 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 CCF36903.1 - 3.4e-07 30.0 1.9 3.8e-06 26.7 0.2 2.5 2 0 0 2 2 2 1 RNA polymerases M/15 Kd subunit IBR PF01485.21 CCF36903.1 - 0.0077 16.4 6.2 1 9.6 0.2 2.4 2 1 0 2 2 2 2 IBR domain, a half RING-finger domain Desulfoferrod_N PF06397.12 CCF36903.1 - 0.012 15.2 0.7 0.11 12.1 0.1 2.3 2 0 0 2 2 2 0 Desulfoferrodoxin, N-terminal domain zf-3CxxC_2 PF17180.4 CCF36903.1 - 0.23 12.2 5.1 5.4 7.8 0.1 2.4 2 1 0 2 2 2 0 Zinc-binding domain zinc_ribbon_4 PF13717.6 CCF36903.1 - 4.9 7.2 9.2 25 4.9 0.3 3.7 4 0 0 4 4 4 0 zinc-ribbon domain Med31 PF05669.12 CCF36904.1 - 8e-36 121.9 1.3 9.5e-36 121.7 1.3 1.0 1 0 0 1 1 1 1 SOH1 F-box-like PF12937.7 CCF36906.1 - 0.0082 16.0 0.1 0.04 13.8 0.0 2.3 2 1 0 2 2 2 1 F-box-like DHHC PF01529.20 CCF36908.1 - 0.09 12.9 0.3 0.09 12.9 0.3 1.9 1 1 0 2 2 2 0 DHHC palmitoyltransferase PIG-P PF08510.12 CCF36908.1 - 0.39 10.6 3.7 0.78 9.7 3.7 1.5 1 0 0 1 1 1 0 PIG-P Phage_holin_3_6 PF07332.11 CCF36909.1 - 0.22 11.6 3.0 0.5 10.4 3.0 1.5 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III HeLo PF14479.6 CCF36911.1 - 7.9e-09 35.6 0.1 9.6e-09 35.4 0.1 1.1 1 0 0 1 1 1 1 Prion-inhibition and propagation DUF2573 PF10835.8 CCF36911.1 - 0.0067 16.7 0.6 0.02 15.2 0.6 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF2573) Osmo_CC PF08946.10 CCF36911.1 - 0.049 13.9 0.1 0.084 13.1 0.1 1.3 1 0 0 1 1 1 0 Osmosensory transporter coiled coil Laminin_II PF06009.12 CCF36911.1 - 0.074 13.1 0.1 0.092 12.8 0.1 1.1 1 0 0 1 1 1 0 Laminin Domain II Pkinase PF00069.25 CCF36912.1 - 9.3e-25 87.5 0.0 2e-24 86.4 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF36912.1 - 2.1e-14 53.5 0.0 6.2e-14 51.9 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CCF36912.1 - 0.0018 17.7 0.0 0.0035 16.7 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CCF36912.1 - 0.034 14.1 0.9 0.14 12.1 0.1 2.2 2 1 1 3 3 3 0 Phosphotransferase enzyme family Glft2_N PF17994.1 CCF36912.1 - 0.09 12.7 0.0 0.48 10.3 0.0 2.0 2 0 0 2 2 2 0 Galactofuranosyltransferase 2 N-terminal Pox_ser-thr_kin PF05445.11 CCF36912.1 - 0.15 11.0 0.0 0.21 10.5 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase RRN3 PF05327.11 CCF36912.1 - 0.2 10.2 1.8 0.24 9.9 1.8 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Paf1 PF03985.13 CCF36912.1 - 0.38 9.7 12.9 0.66 8.9 12.9 1.3 1 0 0 1 1 1 0 Paf1 Nop14 PF04147.12 CCF36912.1 - 0.64 8.2 13.7 0.87 7.7 13.7 1.2 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 CCF36912.1 - 1.2 8.5 15.3 1.8 7.9 15.3 1.1 1 0 0 1 1 1 0 SDA1 DNA_pol_phi PF04931.13 CCF36912.1 - 2.2 6.3 18.5 2.9 5.9 18.5 1.2 1 0 0 1 1 1 0 DNA polymerase phi DUF2457 PF10446.9 CCF36912.1 - 2.7 7.0 19.5 4.1 6.4 19.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) BUD22 PF09073.10 CCF36912.1 - 2.9 7.1 17.0 4.2 6.6 17.0 1.1 1 0 0 1 1 1 0 BUD22 CDC45 PF02724.14 CCF36912.1 - 3.1 6.0 11.3 4.2 5.5 11.3 1.1 1 0 0 1 1 1 0 CDC45-like protein Pes-10 PF07149.11 CCF36912.1 - 4.9 6.1 9.2 7 5.6 9.2 1.2 1 0 0 1 1 1 0 Pes-10 Oxidored_q6 PF01058.22 CCF36914.1 - 7.6e-22 77.5 0.0 1.1e-21 77.1 0.0 1.2 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit Fungal_trans_2 PF11951.8 CCF36915.1 - 3.6e-09 35.9 1.3 5e-09 35.5 1.3 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF36915.1 - 1.8e-07 31.2 12.5 3.1e-07 30.4 12.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pro_dh PF01619.18 CCF36917.1 - 3.5e-58 197.5 0.0 4.4e-58 197.2 0.0 1.1 1 0 0 1 1 1 1 Proline dehydrogenase AP_endonuc_2 PF01261.24 CCF36917.1 - 0.03 13.7 0.1 0.057 12.9 0.1 1.4 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel Glyco_transf_22 PF03901.17 CCF36918.1 - 5.7e-84 282.8 15.2 6.6e-84 282.5 15.2 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family GMC_oxred_N PF00732.19 CCF36919.1 - 1.7e-56 191.8 0.0 4.7e-56 190.3 0.1 1.6 2 0 0 2 2 2 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCF36919.1 - 9.9e-35 120.2 0.0 1.8e-34 119.3 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.12 CCF36919.1 - 9e-05 21.7 0.2 0.00018 20.7 0.1 1.5 2 0 0 2 2 2 1 Lycopene cyclase protein DAO PF01266.24 CCF36919.1 - 0.00041 20.1 0.4 0.0037 16.9 0.2 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCF36919.1 - 0.0055 16.0 0.2 0.13 11.5 0.1 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCF36919.1 - 0.03 14.6 0.9 0.097 12.9 0.9 1.9 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 CCF36919.1 - 0.18 10.9 0.9 0.22 10.6 0.1 1.6 2 0 0 2 2 2 0 FAD binding domain GIDA PF01134.22 CCF36919.1 - 0.61 9.1 2.6 9.8 5.1 0.7 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A Trp_halogenase PF04820.14 CCF36919.1 - 0.64 8.8 2.3 0.57 9.0 0.6 1.8 3 0 0 3 3 3 0 Tryptophan halogenase GMC_oxred_C PF05199.13 CCF36920.1 - 7.1e-21 75.2 0.4 1.2e-20 74.6 0.4 1.4 1 0 0 1 1 1 1 GMC oxidoreductase DUF4050 PF13259.6 CCF36921.1 - 5.9e-62 209.2 0.1 5.9e-62 209.2 0.1 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF4050) BUD22 PF09073.10 CCF36921.1 - 0.0034 16.8 13.1 0.0068 15.8 13.1 1.4 1 0 0 1 1 1 1 BUD22 Spore_coat_CotO PF14153.6 CCF36921.1 - 3.5 7.5 11.0 1.4 8.8 7.1 2.0 2 0 0 2 2 2 0 Spore coat protein CotO COX4 PF02936.14 CCF36922.1 - 3.1e-49 166.5 0.0 3.6e-49 166.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV Alpha-amylase_C PF02806.18 CCF36923.1 - 1e-27 96.5 0.1 1.8e-27 95.7 0.1 1.4 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain Hexapep_2 PF14602.6 CCF36924.1 - 9.5e-14 50.9 8.9 3.4e-10 39.5 2.9 3.4 3 0 0 3 3 3 3 Hexapeptide repeat of succinyl-transferase Hexapep PF00132.24 CCF36924.1 - 1.9e-13 49.6 13.3 4.6e-10 38.8 3.8 3.7 4 0 0 4 4 4 3 Bacterial transferase hexapeptide (six repeats) Mac PF12464.8 CCF36924.1 - 4.7e-09 36.3 0.0 7.4e-09 35.7 0.0 1.4 1 0 0 1 1 1 1 Maltose acetyltransferase Tmemb_170 PF10190.9 CCF36925.1 - 1.1e-24 86.8 14.5 1.2e-24 86.6 14.5 1.0 1 0 0 1 1 1 1 Putative transmembrane protein 170 DUF4383 PF14325.6 CCF36925.1 - 0.067 13.5 10.3 0.2 12.0 10.2 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4383) PS-DH PF14765.6 CCF36927.1 - 2.6e-61 207.5 0.0 5.3e-61 206.5 0.0 1.6 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 CCF36927.1 - 4e-44 151.4 0.1 6.6e-44 150.7 0.1 1.3 1 0 0 1 1 1 1 Acyl transferase domain ADH_zinc_N_2 PF13602.6 CCF36927.1 - 3e-20 73.6 0.0 6.2e-17 62.9 0.0 3.9 3 0 0 3 3 3 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 CCF36927.1 - 4.1e-19 68.8 0.8 3.8e-16 59.2 0.1 3.1 4 0 0 4 4 4 2 Zinc-binding dehydrogenase Methyltransf_23 PF13489.6 CCF36927.1 - 5.9e-06 26.2 0.0 1.4e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain ADH_N PF08240.12 CCF36927.1 - 2.1e-05 24.3 0.6 5.1e-05 23.1 0.6 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain PCMT PF01135.19 CCF36927.1 - 0.097 12.4 0.0 0.19 11.4 0.0 1.5 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DUF3180 PF11377.8 CCF36927.1 - 1.7 8.8 6.1 1.2 9.2 0.8 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3180) Lyase_1 PF00206.20 CCF36928.1 - 4.5e-87 292.4 0.0 5.7e-87 292.0 0.0 1.1 1 0 0 1 1 1 1 Lyase ASL_C2 PF14698.6 CCF36928.1 - 1.6e-21 76.8 0.0 3.3e-21 75.8 0.0 1.5 1 0 0 1 1 1 1 Argininosuccinate lyase C-terminal NTP_transf_9 PF04248.12 CCF36929.1 - 3.5e-39 132.6 0.3 4.9e-31 106.5 0.1 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF427) DUF3425 PF11905.8 CCF36930.1 - 0.0031 17.5 0.1 0.0041 17.1 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) tRNA-synt_2 PF00152.20 CCF36931.1 - 3.3e-79 266.2 0.0 4.1e-79 265.9 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA-synt_2d PF01409.20 CCF36931.1 - 0.16 11.4 0.0 2.9 7.3 0.0 2.1 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) ATP-sulfurylase PF01747.17 CCF36933.1 - 4.5e-87 291.0 0.1 6.8e-87 290.4 0.1 1.2 1 0 0 1 1 1 1 ATP-sulfurylase APS_kinase PF01583.20 CCF36933.1 - 2e-58 196.8 0.0 3.1e-58 196.2 0.0 1.3 1 0 0 1 1 1 1 Adenylylsulphate kinase PUA_2 PF14306.6 CCF36933.1 - 3.1e-54 182.9 0.0 5.3e-54 182.2 0.0 1.4 1 0 0 1 1 1 1 PUA-like domain AAA_18 PF13238.6 CCF36933.1 - 0.11 13.1 0.0 0.22 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain KTI12 PF08433.10 CCF36933.1 - 0.15 11.5 0.0 0.23 10.9 0.0 1.2 1 0 0 1 1 1 0 Chromatin associated protein KTI12 Alpha-amylase PF00128.24 CCF36934.1 - 6.7e-51 173.8 1.2 9.7e-51 173.3 1.2 1.2 1 0 0 1 1 1 1 Alpha amylase, catalytic domain DUF1966 PF09260.11 CCF36934.1 - 2.9e-26 91.6 0.1 5.7e-26 90.6 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1966) Glyco_hydro_3_C PF01915.22 CCF36938.1 - 6.4e-58 196.1 0.0 1.8e-57 194.6 0.0 1.8 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 CCF36938.1 - 2.3e-56 191.5 0.0 3.6e-56 190.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 CCF36938.1 - 1.4e-22 79.6 0.1 3.3e-22 78.4 0.1 1.7 1 0 0 1 1 1 1 Fibronectin type III-like domain PA14 PF07691.12 CCF36938.1 - 2e-22 79.6 0.0 3.1e-22 79.0 0.0 1.3 1 0 0 1 1 1 1 PA14 domain GvpG PF05120.12 CCF36938.1 - 0.063 13.3 0.6 0.14 12.2 0.6 1.5 1 0 0 1 1 1 0 Gas vesicle protein G Metallophos PF00149.28 CCF36939.1 - 2.2e-07 31.6 6.1 9.8e-07 29.5 6.1 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase NAPRTase PF04095.16 CCF36941.1 - 1e-37 130.1 0.1 5.1e-32 111.4 0.2 2.0 1 1 1 2 2 2 2 Nicotinate phosphoribosyltransferase (NAPRTase) family CP2 PF04516.15 CCF36941.1 - 0.017 14.4 0.0 0.022 14.0 0.0 1.2 1 0 0 1 1 1 0 CP2 transcription factor STT3_PglB_C PF18527.1 CCF36941.1 - 0.11 12.6 0.1 0.24 11.5 0.0 1.6 2 0 0 2 2 2 0 STT3/PglB C-terminal beta-barrel domain WSC PF01822.19 CCF36942.1 - 1.4e-18 66.8 6.9 4.2e-18 65.3 6.9 1.9 1 0 0 1 1 1 1 WSC domain RCC1 PF00415.18 CCF36944.1 - 2.8e-33 114.3 7.9 1e-08 35.7 0.0 8.3 7 2 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 CCF36944.1 - 1.5e-16 59.7 23.0 5e-11 42.1 0.0 7.5 7 2 0 7 7 7 2 Regulator of chromosome condensation (RCC1) repeat DNA_gyraseA_C PF03989.13 CCF36944.1 - 0.029 13.8 0.0 7.9 6.0 0.0 2.7 2 0 0 2 2 2 0 DNA gyrase C-terminal domain, beta-propeller NmrA PF05368.13 CCF36946.1 - 6.2e-29 101.2 0.0 7.8e-29 100.9 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CCF36946.1 - 1.8e-12 47.5 0.5 2.4e-12 47.1 0.5 1.2 1 0 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 CCF36946.1 - 0.00021 21.2 0.0 0.0011 18.9 0.0 1.9 1 1 1 2 2 2 1 KR domain Epimerase PF01370.21 CCF36946.1 - 0.0025 17.3 0.0 0.02 14.3 0.0 2.0 1 1 1 2 2 2 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 CCF36946.1 - 0.036 14.5 0.1 0.064 13.7 0.1 1.4 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.20 CCF36946.1 - 0.044 13.9 0.1 0.13 12.4 0.0 1.8 1 1 1 2 2 2 0 Dihydrodipicolinate reductase, N-terminus DUF1365 PF07103.11 CCF36948.1 - 2.6e-61 207.4 0.0 3.3e-61 207.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1365) NAS PF03059.16 CCF36949.1 - 8e-42 143.5 0.0 1.1e-41 143.1 0.0 1.0 1 0 0 1 1 1 1 Nicotianamine synthase protein Methyltransf_31 PF13847.6 CCF36949.1 - 1.3e-09 38.1 0.0 2.6e-09 37.0 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF36949.1 - 0.00023 21.8 0.0 0.00057 20.5 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain AlaDh_PNT_C PF01262.21 CCF36949.1 - 0.00078 18.8 0.0 0.0012 18.2 0.0 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Methyltransf_11 PF08241.12 CCF36949.1 - 0.014 16.0 0.0 0.047 14.4 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 CCF36949.1 - 0.17 11.1 0.1 0.36 10.0 0.1 1.5 1 1 0 1 1 1 0 NNMT/PNMT/TEMT family ATG16 PF08614.11 CCF36951.1 - 9e-06 26.0 5.1 1.9e-05 25.0 5.1 1.5 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Tropomyosin_1 PF12718.7 CCF36951.1 - 0.0027 17.9 7.5 0.003 17.7 2.0 2.3 1 1 1 2 2 2 1 Tropomyosin like CCDC92 PF14916.6 CCF36951.1 - 0.0058 16.4 2.0 0.014 15.1 2.0 1.6 1 0 0 1 1 1 1 Coiled-coil domain of unknown function DivIC PF04977.15 CCF36951.1 - 0.014 15.2 5.2 0.014 15.2 5.2 2.2 2 1 0 2 2 2 0 Septum formation initiator ADIP PF11559.8 CCF36951.1 - 0.017 15.2 3.1 0.05 13.7 3.1 1.8 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF45 PF01863.17 CCF36951.1 - 0.03 14.4 0.7 0.065 13.3 0.7 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF45 Troponin PF00992.20 CCF36951.1 - 0.042 14.2 7.5 0.12 12.7 7.5 1.7 1 1 0 1 1 1 0 Troponin bZIP_1 PF00170.21 CCF36951.1 - 0.096 12.8 6.1 0.55 10.4 2.8 2.4 2 0 0 2 2 2 0 bZIP transcription factor ZapB PF06005.12 CCF36951.1 - 0.13 12.8 7.6 0.35 11.3 7.6 1.9 1 0 0 1 1 1 0 Cell division protein ZapB Jnk-SapK_ap_N PF09744.9 CCF36951.1 - 0.15 12.3 8.3 0.23 11.7 7.6 1.6 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 CENP-Q PF13094.6 CCF36951.1 - 0.15 12.2 5.5 0.32 11.2 5.5 1.5 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit SHE3 PF17078.5 CCF36951.1 - 0.17 11.6 7.5 0.41 10.3 7.5 1.6 1 1 0 1 1 1 0 SWI5-dependent HO expression protein 3 Z1 PF10593.9 CCF36951.1 - 0.21 11.0 2.7 0.21 11.1 0.6 1.9 1 1 1 2 2 2 0 Z1 domain FlxA PF14282.6 CCF36951.1 - 0.47 10.5 5.9 11 6.1 0.0 2.5 1 1 1 2 2 2 0 FlxA-like protein RRP36 PF06102.12 CCF36951.1 - 0.54 10.2 5.8 0.77 9.7 4.9 1.8 1 1 0 1 1 1 0 rRNA biogenesis protein RRP36 TMF_DNA_bd PF12329.8 CCF36951.1 - 0.57 10.2 5.1 1.4 8.9 3.2 2.2 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding Mod_r PF07200.13 CCF36951.1 - 0.61 10.2 9.2 0.14 12.3 5.5 1.8 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein APG6_N PF17675.1 CCF36951.1 - 0.85 10.1 10.4 1.5 9.3 10.4 1.5 1 0 0 1 1 1 0 Apg6 coiled-coil region Herpes_UL6 PF01763.16 CCF36951.1 - 0.96 7.9 4.3 2.9 6.3 1.3 2.2 1 1 1 2 2 2 0 Herpesvirus UL6 like TolA_bind_tri PF16331.5 CCF36951.1 - 1.4 9.0 8.9 4.5 7.4 8.3 2.1 2 0 0 2 2 1 0 TolA binding protein trimerisation Prefoldin_2 PF01920.20 CCF36951.1 - 7.7 6.5 9.8 3.8 7.5 1.9 2.9 2 1 0 2 2 2 0 Prefoldin subunit NGP1NT PF08153.12 CCF36952.1 - 9.6e-51 171.3 0.0 1.6e-50 170.6 0.0 1.4 1 0 0 1 1 1 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.23 CCF36952.1 - 9.5e-18 64.4 0.0 8.5e-14 51.6 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.18 CCF36952.1 - 2.5e-05 23.9 0.1 0.00012 21.6 0.0 1.9 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 CCF36952.1 - 4.8e-05 23.3 0.0 0.00017 21.5 0.0 2.0 2 1 0 2 2 2 1 RsgA GTPase Arf PF00025.21 CCF36952.1 - 0.0016 17.9 0.1 0.23 10.9 0.0 2.3 2 0 0 2 2 2 2 ADP-ribosylation factor family GTP_EFTU PF00009.27 CCF36952.1 - 0.0042 16.6 0.0 0.29 10.7 0.0 2.8 1 1 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 CCF36952.1 - 0.082 13.3 0.0 0.22 11.9 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain Roc PF08477.13 CCF36952.1 - 0.11 12.7 0.0 4.3 7.6 0.0 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.23 CCF36952.1 - 0.13 12.3 0.4 5 7.1 0.1 3.0 2 1 1 3 3 3 0 Dynamin family GMC_oxred_N PF00732.19 CCF36953.1 - 1.6e-37 129.5 0.0 2.5e-37 128.8 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCF36953.1 - 1e-05 26.1 0.0 2.1e-05 25.1 0.0 1.6 1 1 0 1 1 1 1 GMC oxidoreductase zf-C2H2 PF00096.26 CCF36954.1 - 0.00074 19.8 1.0 0.0018 18.6 1.0 1.7 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCF36954.1 - 0.008 16.9 0.7 0.027 15.3 0.3 2.2 1 1 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CCF36954.1 - 0.017 15.4 0.2 0.044 14.1 0.2 1.7 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding Sprouty PF05210.13 CCF36954.1 - 0.019 15.4 0.9 0.026 14.9 0.9 1.3 1 0 0 1 1 1 0 Sprouty protein (Spry) Oxidored_q6 PF01058.22 CCF36955.1 - 2e-23 82.6 0.1 2.6e-23 82.3 0.1 1.1 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit DEC-1_C PF04626.13 CCF36955.1 - 0.08 13.3 0.3 0.12 12.8 0.3 1.2 1 0 0 1 1 1 0 Dec-1 protein, C terminal region Fungal_trans_2 PF11951.8 CCF36956.1 - 8.4e-07 28.1 0.2 2.6e-06 26.5 0.0 1.8 2 1 0 2 2 2 1 Fungal specific transcription factor domain p450 PF00067.22 CCF36957.1 - 3.8e-48 164.4 0.0 4.9e-48 164.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Phosphonate-bd PF12974.7 CCF36957.1 - 0.13 11.8 0.1 0.22 11.1 0.1 1.3 1 0 0 1 1 1 0 ABC transporter, phosphonate, periplasmic substrate-binding protein ADH_zinc_N PF00107.26 CCF36958.1 - 1.1e-21 77.1 0.2 1.9e-21 76.4 0.2 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCF36958.1 - 6.3e-12 46.7 0.1 1.3e-11 45.7 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCF36958.1 - 2.6e-06 27.3 0.0 6.5e-06 26.0 0.0 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Glu_dehyd_C PF16912.5 CCF36958.1 - 0.0031 17.0 1.3 0.0047 16.4 0.3 1.7 1 1 1 2 2 2 1 Glucose dehydrogenase C-terminus Sacchrp_dh_NADP PF03435.18 CCF36958.1 - 0.0043 17.3 0.2 0.022 15.0 0.1 2.0 1 1 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain DEAD PF00270.29 CCF36959.1 - 0.0054 16.5 0.0 0.0081 15.9 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase EI24 PF07264.11 CCF36960.1 - 2.2e-08 34.5 21.1 4.7e-08 33.5 21.1 1.4 1 1 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) Lip_A_acyltrans PF03279.13 CCF36960.1 - 0.42 9.7 4.6 3.4 6.8 1.6 2.3 2 0 0 2 2 2 0 Bacterial lipid A biosynthesis acyltransferase AAA_12 PF13087.6 CCF36962.1 - 5e-40 137.3 0.0 7.8e-40 136.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 CCF36962.1 - 2.3e-23 83.3 0.1 2.1e-22 80.1 0.1 2.2 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CCF36962.1 - 4.6e-09 36.8 0.0 3.2e-08 34.0 0.0 2.5 1 1 0 1 1 1 1 AAA domain zf-CCCH_4 PF18044.1 CCF36962.1 - 2.3e-08 33.6 1.6 1.2e-07 31.3 1.6 2.4 1 0 0 1 1 1 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 CCF36962.1 - 8.3e-06 25.7 6.0 2.9e-05 24.0 6.0 2.1 1 0 0 1 1 1 1 Zinc finger domain AAA_30 PF13604.6 CCF36962.1 - 1e-05 25.3 0.0 0.0081 15.9 0.0 3.1 3 0 0 3 3 3 2 AAA domain DUF2075 PF09848.9 CCF36962.1 - 7.1e-05 22.2 0.1 0.28 10.4 0.0 2.2 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) Viral_helicase1 PF01443.18 CCF36962.1 - 0.0024 17.6 0.5 0.033 13.9 0.0 2.8 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase ResIII PF04851.15 CCF36962.1 - 0.019 15.0 0.0 0.038 14.0 0.0 1.4 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_22 PF13401.6 CCF36962.1 - 0.071 13.4 0.3 1.5 9.1 0.0 3.1 3 0 0 3 3 3 0 AAA domain SWI2_SNF2 PF18766.1 CCF36962.1 - 0.12 12.0 0.1 0.47 10.1 0.0 1.9 2 0 0 2 2 2 0 SWI2/SNF2 ATPase AAA_16 PF13191.6 CCF36962.1 - 5.5 7.4 6.0 11 6.4 0.6 3.6 3 1 0 3 3 2 0 AAA ATPase domain MFS_1 PF07690.16 CCF36963.1 - 2.3e-25 89.3 60.5 5.4e-24 84.8 41.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2754 PF10953.8 CCF36963.1 - 5.1 7.4 6.0 8.4 6.7 0.2 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2754) Epimerase PF01370.21 CCF36965.1 - 2.9e-12 46.6 0.1 8.5e-12 45.0 0.1 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CCF36965.1 - 1.2e-09 37.6 0.0 1.6e-09 37.2 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 CCF36965.1 - 8.8e-09 35.5 0.0 1.4e-08 34.8 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 CCF36965.1 - 4e-08 32.7 0.0 5.4e-05 22.5 0.0 2.1 2 0 0 2 2 2 2 Male sterility protein GDP_Man_Dehyd PF16363.5 CCF36965.1 - 1.1e-07 31.6 0.1 7.7e-07 28.8 0.0 2.0 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NmrA PF05368.13 CCF36965.1 - 0.0012 18.4 0.0 0.002 17.7 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family Polysacc_synt_2 PF02719.15 CCF36965.1 - 0.21 10.7 0.0 0.31 10.1 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein bZIP_2 PF07716.15 CCF36968.1 - 1.2e-05 25.2 18.6 4.5e-05 23.5 18.6 2.0 1 1 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 CCF36968.1 - 3.8e-05 23.7 17.1 8.1e-05 22.6 17.1 1.5 1 0 0 1 1 1 1 bZIP transcription factor bZIP_Maf PF03131.17 CCF36968.1 - 0.0054 17.2 11.3 0.014 15.9 11.3 1.7 1 0 0 1 1 1 1 bZIP Maf transcription factor TPR_2 PF07719.17 CCF36969.1 - 5.2e-08 32.4 8.8 9.1e-07 28.5 1.8 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 CCF36969.1 - 8.6e-08 31.7 8.9 7.5e-05 22.4 1.6 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 CCF36969.1 - 3.1e-06 27.0 5.9 2.2e-05 24.3 1.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 CCF36969.1 - 0.0057 16.9 6.5 0.012 15.8 4.7 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 CCF36969.1 - 0.013 16.1 3.5 0.018 15.6 1.5 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat NYD-SP28 PF14772.6 CCF36969.1 - 0.058 13.4 1.9 0.61 10.2 0.3 2.6 2 0 0 2 2 2 0 Sperm tail TPR_7 PF13176.6 CCF36969.1 - 0.07 13.2 2.5 0.13 12.4 0.2 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_3 PF07720.12 CCF36969.1 - 0.099 12.7 1.6 0.19 11.8 1.6 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_14 PF13428.6 CCF36969.1 - 0.17 12.8 3.5 0.44 11.5 0.2 2.9 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 CCF36969.1 - 5 7.9 12.8 0.96 10.1 0.8 3.0 3 1 0 3 3 3 0 Tetratricopeptide repeat Aldo_ket_red PF00248.21 CCF36970.1 - 5.7e-67 226.0 0.0 7.1e-67 225.7 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family zf-HC5HC2H_2 PF13832.6 CCF36971.1 - 1.3e-33 115.4 7.7 1.3e-33 115.4 7.7 2.4 2 0 0 2 2 2 1 PHD-zinc-finger like domain EPL1 PF10513.9 CCF36971.1 - 2.5e-28 99.5 0.1 2.5e-28 99.5 0.1 2.4 3 0 0 3 3 3 1 Enhancer of polycomb-like zf-HC5HC2H PF13771.6 CCF36971.1 - 3.8e-26 91.2 7.5 3.8e-26 91.2 7.5 2.7 3 0 0 3 3 3 1 PHD-like zinc-binding domain PHD_2 PF13831.6 CCF36971.1 - 3.4e-14 52.1 1.9 3.4e-14 52.1 1.9 2.5 2 0 0 2 2 2 1 PHD-finger PHD PF00628.29 CCF36971.1 - 1.8e-09 37.4 23.4 1.3e-08 34.6 9.5 2.7 2 0 0 2 2 2 2 PHD-finger zf-PHD-like PF15446.6 CCF36971.1 - 2.2 7.9 13.3 0.017 14.7 1.6 2.4 2 0 0 2 2 2 0 PHD/FYVE-zinc-finger like domain ARGLU PF15346.6 CCF36972.1 - 9 6.2 41.9 0.78 9.6 22.4 2.4 2 0 0 2 2 2 0 Arginine and glutamate-rich 1 INSC_LBD PF16748.5 CCF36975.1 - 0.13 11.7 0.1 0.23 10.9 0.1 1.3 1 0 0 1 1 1 0 Inscuteable LGN-binding domain SH3_1 PF00018.28 CCF36976.1 - 3.7e-09 36.1 0.0 5.9e-09 35.4 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 CCF36976.1 - 7.8e-08 32.1 0.1 1.7e-07 31.0 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 CCF36976.1 - 2.2e-05 24.0 0.0 8.3e-05 22.2 0.0 1.9 2 0 0 2 2 2 1 Variant SH3 domain DUF3112 PF11309.8 CCF36977.1 - 8.7e-11 41.7 0.0 8.7e-11 41.7 0.0 2.6 3 0 0 3 3 3 1 Protein of unknown function (DUF3112) ECSCR PF15820.5 CCF36977.1 - 0.1 12.5 0.8 20 5.1 0.4 2.5 2 0 0 2 2 2 0 Endothelial cell-specific chemotaxis regulator WD40 PF00400.32 CCF36979.1 - 4.4e-34 115.9 27.6 2.1e-07 31.5 0.0 7.0 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF36979.1 - 3.2e-15 56.2 5.1 0.00062 20.0 0.1 4.3 2 2 2 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CCF36979.1 - 1.8e-06 27.2 0.2 0.17 10.8 0.0 3.5 2 2 2 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 CCF36979.1 - 2.7e-05 24.1 1.7 0.00011 22.1 0.0 2.4 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 CCF36979.1 - 0.0054 15.4 6.6 0.64 8.6 0.1 3.2 2 2 1 4 4 4 2 Nucleoporin Nup120/160 DinB PF05163.12 CCF36979.1 - 0.058 13.3 0.3 0.1 12.6 0.3 1.3 1 0 0 1 1 1 0 DinB family FAD_binding_9 PF08021.11 CCF36979.1 - 0.077 13.2 0.0 0.47 10.7 0.0 2.1 2 0 0 2 2 2 0 Siderophore-interacting FAD-binding domain WD40_like PF17005.5 CCF36979.1 - 0.18 11.1 0.0 10 5.3 0.0 2.6 3 0 0 3 3 3 0 WD40-like domain NAD_binding_8 PF13450.6 CCF36980.1 - 7e-06 26.2 0.0 1.1e-05 25.6 0.0 1.3 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 CCF36980.1 - 2e-05 24.1 0.0 2.6e-05 23.7 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase HI0933_like PF03486.14 CCF36980.1 - 0.21 10.2 0.0 0.28 9.9 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein adh_short PF00106.25 CCF36981.1 - 1e-14 54.5 0.2 1.3e-14 54.1 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF36981.1 - 1.3e-11 44.5 0.1 1.4e-11 44.4 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.6 CCF36981.1 - 4e-07 30.1 2.2 1.1e-06 28.6 0.5 2.0 2 0 0 2 2 2 1 NAD(P)H-binding NmrA PF05368.13 CCF36981.1 - 1e-05 25.2 1.1 2.4e-05 24.0 1.1 1.6 1 0 0 1 1 1 1 NmrA-like family KR PF08659.10 CCF36981.1 - 9.6e-05 22.4 0.1 0.00012 22.0 0.1 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF36981.1 - 0.0014 18.2 0.1 0.0022 17.5 0.1 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family F420_oxidored PF03807.17 CCF36981.1 - 0.028 15.0 0.2 0.065 13.8 0.2 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent GDP_Man_Dehyd PF16363.5 CCF36981.1 - 0.028 13.8 0.1 0.042 13.2 0.1 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase DapB_N PF01113.20 CCF36981.1 - 0.051 13.7 1.9 0.48 10.6 0.8 2.1 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus YcbB PF08664.10 CCF36981.1 - 0.054 13.5 0.0 0.094 12.8 0.0 1.3 1 0 0 1 1 1 0 YcbB domain RmlD_sub_bind PF04321.17 CCF36981.1 - 0.062 12.4 0.0 0.12 11.5 0.0 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain DUF2263 PF10021.9 CCF36983.1 - 4.4e-12 46.6 0.0 1.1e-11 45.3 0.0 1.7 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2263) Macro PF01661.21 CCF36983.1 - 0.0014 18.7 0.0 0.025 14.6 0.0 2.2 2 0 0 2 2 2 1 Macro domain BUD22 PF09073.10 CCF36983.1 - 0.0087 15.5 6.0 0.015 14.7 6.0 1.4 1 0 0 1 1 1 1 BUD22 EcKinase PF02958.20 CCF36984.1 - 1.4e-13 50.9 0.0 2.7e-13 49.9 0.0 1.4 1 1 0 1 1 1 1 Ecdysteroid kinase APH PF01636.23 CCF36984.1 - 1.9e-08 34.5 0.7 9.6e-07 29.0 0.0 2.6 1 1 1 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CCF36984.1 - 0.0003 20.4 0.0 0.0006 19.5 0.0 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase DUF1679 PF07914.11 CCF36984.1 - 0.23 10.3 0.0 0.43 9.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) Peptidase_M20 PF01546.28 CCF36985.1 - 1.5e-22 80.3 0.4 2.6e-22 79.6 0.4 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 CCF36985.1 - 3.2e-13 49.6 0.1 6.1e-13 48.6 0.1 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Spatacsin_C PF14649.6 CCF36985.1 - 0.088 11.9 0.0 0.14 11.3 0.0 1.2 1 0 0 1 1 1 0 Spatacsin C-terminus Gln-synt_C PF00120.24 CCF36987.1 - 3.2e-86 289.5 0.0 4e-86 289.1 0.0 1.1 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N_2 PF16952.5 CCF36987.1 - 0.076 12.9 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 Glutamine synthetase N-terminal domain FA_hydroxylase PF04116.13 CCF36988.1 - 4.4e-26 91.8 18.7 4.4e-26 91.8 18.7 2.0 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily zf-primase PF09329.11 CCF36989.1 - 0.094 12.5 0.1 0.26 11.1 0.1 1.7 1 1 0 1 1 1 0 Primase zinc finger PAN_1 PF00024.26 CCF36990.1 - 0.057 13.4 0.0 0.12 12.3 0.0 1.5 1 1 0 1 1 1 0 PAN domain Pyr_redox_2 PF07992.14 CCF36993.1 - 1.1e-51 175.9 1.2 1.3e-51 175.6 1.2 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCF36993.1 - 1.1e-18 67.5 0.9 2.8e-17 62.9 0.1 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCF36993.1 - 1.3e-18 67.3 2.3 1.4e-16 60.8 0.5 2.9 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 CCF36993.1 - 2.6e-06 27.8 0.1 0.00042 20.7 0.1 2.5 2 1 0 2 2 2 1 Putative NAD(P)-binding Thi4 PF01946.17 CCF36993.1 - 4.9e-05 22.7 0.2 0.00064 19.0 0.1 2.2 2 0 0 2 2 2 1 Thi4 family NAD_binding_8 PF13450.6 CCF36993.1 - 0.00014 22.0 0.6 0.042 14.1 0.0 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 CCF36993.1 - 0.00018 20.7 0.1 0.0058 15.8 0.0 2.8 2 1 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 CCF36993.1 - 0.00044 19.9 0.5 4.1 6.9 0.0 3.3 3 0 0 3 3 3 2 FAD dependent oxidoreductase GIDA PF01134.22 CCF36993.1 - 0.00097 18.3 4.8 0.55 9.2 0.3 3.9 3 1 0 4 4 4 2 Glucose inhibited division protein A Shikimate_DH PF01488.20 CCF36993.1 - 0.0021 18.2 0.4 0.81 9.7 0.1 2.7 2 1 1 3 3 3 1 Shikimate / quinate 5-dehydrogenase FAD_binding_2 PF00890.24 CCF36993.1 - 0.0055 15.8 6.6 0.25 10.4 0.5 2.9 3 0 0 3 3 3 2 FAD binding domain Attacin_N PF03768.15 CCF36993.1 - 0.027 14.6 0.0 0.077 13.1 0.0 1.8 1 0 0 1 1 1 0 Attacin, N-terminal region HI0933_like PF03486.14 CCF36993.1 - 0.027 13.2 0.2 2.6 6.7 0.1 3.0 3 0 0 3 3 3 0 HI0933-like protein Trp_halogenase PF04820.14 CCF36993.1 - 0.035 13.0 0.3 0.47 9.2 0.0 2.1 2 0 0 2 2 2 0 Tryptophan halogenase FAD_oxidored PF12831.7 CCF36993.1 - 0.037 13.4 0.4 0.061 12.7 0.0 1.6 2 0 0 2 2 2 0 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 CCF36993.1 - 0.12 11.6 0.6 2.8 7.1 0.0 2.5 2 1 1 3 3 3 0 FAD binding domain MFS_1 PF07690.16 CCF36994.1 - 2.6e-34 118.7 38.1 1.4e-24 86.7 7.5 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 CCF36994.1 - 8.9e-05 21.1 0.3 0.00014 20.5 0.3 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Pkinase PF00069.25 CCF36996.1 - 4.3e-24 85.3 0.0 9.1e-24 84.2 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF36996.1 - 1.4e-15 57.3 0.0 2.2e-15 56.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Sec63 PF02889.16 CCF36997.1 - 3.5e-49 167.3 0.1 6.8e-49 166.3 0.1 1.5 1 0 0 1 1 1 1 Sec63 Brl domain Helicase_PWI PF18149.1 CCF36997.1 - 1e-34 119.0 1.3 3.9e-34 117.2 1.3 2.1 1 0 0 1 1 1 1 N-terminal helicase PWI domain DEAD PF00270.29 CCF36997.1 - 8.7e-30 103.8 0.0 6.6e-29 100.9 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 CCF36997.1 - 9.7e-15 55.0 0.0 2e-14 53.9 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 CCF36997.1 - 4.8e-09 36.5 0.1 1.3e-07 31.9 0.0 2.9 2 1 0 2 2 2 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 CCF36997.1 - 0.0015 18.8 0.1 0.008 16.4 0.1 2.2 1 1 0 1 1 1 1 AAA domain SSrecog PF03531.14 CCF36997.1 - 0.21 11.5 0.5 2 8.4 0.1 2.5 2 0 0 2 2 2 0 Structure-specific recognition protein (SSRP1) DUF2031 PF09592.10 CCF36998.1 - 0.032 13.8 0.5 0.051 13.1 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2031) Exonuc_VII_S PF02609.16 CCF36998.1 - 0.075 13.1 0.4 0.075 13.1 0.4 2.2 2 0 0 2 2 2 0 Exonuclease VII small subunit Hep_59 PF07052.11 CCF36998.1 - 0.12 13.1 0.3 0.12 13.1 0.3 2.9 3 1 0 3 3 3 0 Hepatocellular carcinoma-associated antigen 59 FMO-like PF00743.19 CCF36999.1 - 0.046 12.1 0.0 0.046 12.1 0.0 1.2 1 0 0 1 1 1 0 Flavin-binding monooxygenase-like Aldo_ket_red PF00248.21 CCF37000.1 - 4.4e-69 232.9 0.0 5e-69 232.7 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family AsnC_trans_reg2 PF17805.1 CCF37000.1 - 0.11 12.6 0.0 0.24 11.6 0.0 1.6 1 0 0 1 1 1 0 AsnC-like ligand binding domain PIP49_C PF12260.8 CCF37001.1 - 0.19 11.4 0.0 0.23 11.1 0.0 1.1 1 0 0 1 1 1 0 Protein-kinase domain of FAM69 CFEM PF05730.11 CCF37002.1 - 3.7e-14 52.6 10.3 5.8e-14 51.9 10.3 1.3 1 0 0 1 1 1 1 CFEM domain Gamma-thionin PF00304.20 CCF37002.1 - 0.022 15.0 1.4 0.022 15.0 1.4 1.7 2 0 0 2 2 2 0 Gamma-thionin family NESP55 PF06390.12 CCF37003.1 - 0.00029 20.5 2.2 0.00038 20.1 2.2 1.2 1 0 0 1 1 1 1 Neuroendocrine-specific golgi protein P55 (NESP55) HET PF06985.11 CCF37004.1 - 1.5e-12 48.1 4.1 6.9e-10 39.5 0.6 2.4 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) RPEL PF02755.15 CCF37005.1 - 8.3e-22 76.2 5.3 3.6e-10 39.2 1.0 2.5 2 0 0 2 2 2 2 RPEL repeat DHHC PF01529.20 CCF37007.1 - 2.3e-22 79.5 1.2 2.3e-22 79.5 1.2 2.0 2 1 0 2 2 2 1 DHHC palmitoyltransferase DUF2722 PF10846.8 CCF37007.1 - 0.00099 18.2 1.8 0.0013 17.8 1.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Yip1 PF04893.17 CCF37007.1 - 0.0067 16.2 4.5 0.023 14.4 0.2 2.2 2 0 0 2 2 2 1 Yip1 domain Spt20 PF12090.8 CCF37007.1 - 0.045 13.4 8.9 0.067 12.8 8.9 1.2 1 0 0 1 1 1 0 Spt20 family DUF3682 PF12446.8 CCF37007.1 - 5.4 7.5 11.4 11 6.6 11.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) SUIM_assoc PF16619.5 CCF37007.1 - 6.8 6.8 20.0 16 5.6 20.0 1.6 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Amidohydro_3 PF07969.11 CCF37009.1 - 3.8e-58 198.1 0.3 4.3e-58 197.9 0.3 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_1 PF01979.20 CCF37009.1 - 8e-06 25.4 0.0 0.086 12.1 0.0 2.4 2 0 0 2 2 2 2 Amidohydrolase family DUF4551 PF15087.6 CCF37010.1 - 0.06 12.2 7.2 0.068 12.0 7.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Spt20 PF12090.8 CCF37010.1 - 0.1 12.2 11.9 0.13 11.9 11.9 1.2 1 0 0 1 1 1 0 Spt20 family FAM70 PF14967.6 CCF37010.1 - 0.86 9.0 3.6 0.92 8.9 3.6 1.1 1 0 0 1 1 1 0 FAM70 protein Neur_chan_memb PF02932.16 CCF37010.1 - 2.2 8.3 5.3 2.4 8.1 5.3 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Pex14_N PF04695.13 CCF37010.1 - 2.4 8.8 12.7 3.2 8.4 12.7 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Ndc1_Nup PF09531.10 CCF37010.1 - 7.7 5.1 6.3 7.4 5.1 6.3 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup UCR_hinge PF02320.16 CCF37012.1 - 9.1e-27 93.1 11.6 9.1e-27 93.1 11.6 1.9 2 1 0 2 2 1 1 Ubiquinol-cytochrome C reductase hinge protein Mpp10 PF04006.12 CCF37012.1 - 0.046 12.2 21.7 0.054 11.9 21.7 1.0 1 0 0 1 1 1 0 Mpp10 protein RR_TM4-6 PF06459.12 CCF37012.1 - 0.051 13.4 17.2 0.061 13.1 17.2 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4471 PF14740.6 CCF37012.1 - 0.061 12.5 3.6 0.082 12.1 3.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) Sigma70_ner PF04546.13 CCF37012.1 - 0.11 12.4 16.9 0.14 12.0 16.9 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region CDC45 PF02724.14 CCF37012.1 - 0.41 8.9 14.5 0.41 8.9 14.5 1.0 1 0 0 1 1 1 0 CDC45-like protein BUD22 PF09073.10 CCF37012.1 - 0.47 9.7 23.0 0.54 9.6 23.0 1.0 1 0 0 1 1 1 0 BUD22 Nop14 PF04147.12 CCF37012.1 - 0.89 7.7 24.9 0.97 7.6 24.9 1.0 1 0 0 1 1 1 0 Nop14-like family Myc_N PF01056.18 CCF37012.1 - 1.2 9.0 15.8 1.3 8.9 15.8 1.2 1 0 0 1 1 1 0 Myc amino-terminal region Cellulose_synt PF03552.14 CCF37012.1 - 1.5 7.3 2.8 1.5 7.2 2.8 1.0 1 0 0 1 1 1 0 Cellulose synthase SpoIIP PF07454.11 CCF37012.1 - 2.3 7.6 12.4 2.6 7.4 12.4 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) NPR3 PF03666.13 CCF37012.1 - 2.4 6.9 8.4 2.6 6.8 8.4 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Neur_chan_memb PF02932.16 CCF37012.1 - 3 7.8 7.4 3.3 7.7 7.4 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Sec62 PF03839.16 CCF37012.1 - 3.3 7.2 7.2 4 6.9 7.2 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 LAP1C PF05609.12 CCF37012.1 - 3.4 6.6 14.4 3.6 6.6 14.4 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DUF4045 PF13254.6 CCF37012.1 - 3.7 7.1 15.7 4.1 7.0 15.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Tim54 PF11711.8 CCF37012.1 - 4.4 6.0 17.1 5 5.8 17.1 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 CobT PF06213.12 CCF37012.1 - 4.5 6.6 24.4 5.2 6.4 24.4 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT SLC12 PF03522.15 CCF37012.1 - 4.6 6.2 6.0 5 6.0 6.0 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Raftlin PF15250.6 CCF37012.1 - 5.9 5.5 11.2 6.6 5.4 11.2 1.0 1 0 0 1 1 1 0 Raftlin PPL5 PF18168.1 CCF37012.1 - 6.4 6.0 7.6 7.4 5.8 7.6 1.2 1 0 0 1 1 1 0 Prim-pol family 5 SAPS PF04499.15 CCF37012.1 - 7.6 5.2 10.3 8.1 5.1 10.3 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Paf1 PF03985.13 CCF37012.1 - 8.6 5.2 25.5 10 5.0 25.5 1.2 1 0 0 1 1 1 0 Paf1 Eapp_C PF10238.9 CCF37013.1 - 0.032 14.3 0.0 0.033 14.3 0.0 1.1 1 0 0 1 1 1 0 E2F-associated phosphoprotein Zn_clus PF00172.18 CCF37014.1 - 1.2e-11 44.5 12.9 1.4e-11 44.3 12.9 1.1 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RseC_MucC PF04246.12 CCF37014.1 - 1.6 8.7 7.8 17 5.4 7.8 1.9 1 1 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC Fungal_trans PF04082.18 CCF37015.1 - 6.5e-12 45.0 0.6 4.6e-11 42.3 0.2 2.3 1 1 1 2 2 2 1 Fungal specific transcription factor domain Malate_synthase PF01274.22 CCF37016.1 - 8.3e-101 337.8 0.0 9.1e-101 337.7 0.0 1.0 1 0 0 1 1 1 1 Malate synthase APH PF01636.23 CCF37017.1 - 5.3e-33 114.9 0.0 7.5e-33 114.4 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 CCF37017.1 - 0.0069 16.0 0.0 0.47 10.0 0.0 2.2 2 0 0 2 2 2 2 RIO1 family Fructosamin_kin PF03881.14 CCF37017.1 - 0.0087 15.3 0.0 0.038 13.2 0.0 1.9 1 1 0 1 1 1 1 Fructosamine kinase EcKinase PF02958.20 CCF37017.1 - 0.026 13.8 0.0 0.038 13.3 0.0 1.2 1 0 0 1 1 1 0 Ecdysteroid kinase Kdo PF06293.14 CCF37017.1 - 0.032 13.6 0.0 0.26 10.6 0.0 2.0 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family CBFB_NFYA PF02045.15 CCF37018.1 - 1e-28 99.7 4.6 2.3e-28 98.6 4.6 1.6 1 0 0 1 1 1 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B TFIIA PF03153.13 CCF37018.1 - 0.038 14.0 18.6 0.047 13.7 18.6 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Hus1 PF04005.12 CCF37018.1 - 0.058 12.5 0.1 0.11 11.6 0.1 1.3 1 0 0 1 1 1 0 Hus1-like protein Ligase_CoA PF00549.19 CCF37019.1 - 1.9e-18 66.7 0.4 3.1e-18 66.0 0.4 1.3 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.6 CCF37019.1 - 5.9e-10 39.1 0.1 9.2e-10 38.5 0.1 1.3 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding PF02629.19 CCF37019.1 - 0.00053 20.6 2.0 0.00053 20.6 2.0 2.3 3 0 0 3 3 3 1 CoA binding domain Fungal_trans PF04082.18 CCF37020.1 - 2.6e-24 85.7 0.0 3.8e-24 85.2 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF37020.1 - 3.7e-05 23.8 11.0 6.7e-05 22.9 11.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sugar_tr PF00083.24 CCF37023.1 - 3.9e-78 263.3 22.3 4.8e-78 263.0 22.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF37023.1 - 4.9e-26 91.5 28.4 2e-20 73.0 13.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 CCF37023.1 - 0.012 14.0 4.3 0.029 12.7 0.3 2.8 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family ABC_membrane PF00664.23 CCF37025.1 - 2.2e-53 181.7 34.8 1.7e-32 113.2 15.3 3.1 3 0 0 3 3 3 3 ABC transporter transmembrane region ABC_tran PF00005.27 CCF37025.1 - 1.5e-47 161.5 0.0 4.6e-27 95.2 0.0 2.7 2 0 0 2 2 2 2 ABC transporter AAA_16 PF13191.6 CCF37025.1 - 1.1e-05 25.9 0.1 0.15 12.5 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain SMC_N PF02463.19 CCF37025.1 - 3.6e-05 23.3 0.3 0.96 8.8 0.1 3.4 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 CCF37025.1 - 4.7e-05 23.5 1.8 0.054 13.6 0.1 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase Zeta_toxin PF06414.12 CCF37025.1 - 9.1e-05 21.8 0.0 0.0092 15.3 0.0 2.3 2 0 0 2 2 2 1 Zeta toxin RsgA_GTPase PF03193.16 CCF37025.1 - 0.00013 21.9 1.1 0.057 13.3 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 CCF37025.1 - 0.00033 20.3 1.2 0.42 10.4 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 CCF37025.1 - 0.00063 20.3 2.4 1 9.9 0.0 3.2 3 0 0 3 3 3 2 AAA domain AAA_30 PF13604.6 CCF37025.1 - 0.00087 19.1 1.0 0.45 10.2 0.1 2.6 2 0 0 2 2 2 2 AAA domain AAA_21 PF13304.6 CCF37025.1 - 0.0037 17.1 1.1 1.8 8.3 0.1 2.7 3 0 0 3 3 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 CCF37025.1 - 0.0054 17.0 1.4 3.7 7.8 0.0 3.1 2 1 0 2 2 2 1 AAA domain TrwB_AAD_bind PF10412.9 CCF37025.1 - 0.0059 15.6 0.4 0.83 8.5 0.0 2.4 2 0 0 2 2 2 1 Type IV secretion-system coupling protein DNA-binding domain DUF87 PF01935.17 CCF37025.1 - 0.011 15.8 3.2 0.14 12.2 0.4 2.3 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_28 PF13521.6 CCF37025.1 - 0.024 14.9 0.5 0.13 12.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain Roc PF08477.13 CCF37025.1 - 0.032 14.5 0.1 6.5 7.0 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_7 PF12775.7 CCF37025.1 - 0.063 12.8 0.6 3.1 7.3 0.1 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region NACHT PF05729.12 CCF37025.1 - 0.068 13.1 0.6 0.58 10.1 0.0 2.4 2 0 0 2 2 2 0 NACHT domain AAA_15 PF13175.6 CCF37025.1 - 0.071 12.8 0.2 1.1 8.8 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain SRP54 PF00448.22 CCF37025.1 - 0.072 12.7 0.5 0.64 9.6 0.1 2.4 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain Dynamin_N PF00350.23 CCF37025.1 - 0.1 12.7 3.9 0.71 9.9 0.3 2.5 2 0 0 2 2 2 0 Dynamin family MeaB PF03308.16 CCF37025.1 - 0.12 11.3 1.2 0.65 8.9 0.2 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB IstB_IS21 PF01695.17 CCF37025.1 - 0.15 11.8 0.0 3.5 7.3 0.0 2.3 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_18 PF13238.6 CCF37025.1 - 0.2 12.2 0.8 6.6 7.3 0.0 2.6 2 0 0 2 2 2 0 AAA domain ATP_bind_1 PF03029.17 CCF37025.1 - 0.51 10.1 2.1 13 5.5 0.3 2.5 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein NB-ARC PF00931.22 CCF37025.1 - 0.67 9.1 1.8 13 4.9 0.5 2.3 2 0 0 2 2 2 0 NB-ARC domain cobW PF02492.19 CCF37025.1 - 1.2 8.7 3.2 1.7 8.2 0.3 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain FKBP_N PF01346.18 CCF37026.1 - 0.079 13.9 0.2 0.26 12.3 0.2 1.9 1 0 0 1 1 1 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase Podoplanin PF05808.11 CCF37027.1 - 2.7e-05 24.4 0.1 7.8e-05 22.8 0.1 1.8 1 0 0 1 1 1 1 Podoplanin MtrF PF09472.10 CCF37027.1 - 0.047 13.1 2.8 0.086 12.2 2.8 1.4 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) Insulin_TMD PF17870.1 CCF37027.1 - 0.07 13.2 0.1 0.16 12.1 0.1 1.5 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment Ku_C PF03730.14 CCF37028.1 - 0.11 13.1 6.5 0.21 12.3 0.5 3.0 3 0 0 3 3 3 0 Ku70/Ku80 C-terminal arm PIN PF01850.21 CCF37028.1 - 1.2 9.6 5.8 0.27 11.7 1.2 2.2 1 1 1 2 2 2 0 PIN domain HsdM_N PF12161.8 CCF37028.1 - 2 9.1 8.4 4.4 7.9 8.1 1.7 1 1 0 1 1 1 0 HsdM N-terminal domain SUR7 PF06687.12 CCF37030.1 - 7.4e-07 29.0 0.1 2.4e-06 27.3 0.1 1.8 1 1 0 1 1 1 1 SUR7/PalI family UPF0182 PF03699.13 CCF37030.1 - 0.073 11.2 0.1 0.067 11.3 0.1 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0182) DUF4405 PF14358.6 CCF37030.1 - 0.6 10.7 0.1 0.6 10.7 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4405) HTH_Tnp_Tc5 PF03221.16 CCF37033.1 - 9e-11 41.6 0.1 1.8e-10 40.7 0.1 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 CCF37033.1 - 1.6e-08 34.1 0.1 2.9e-08 33.3 0.1 1.4 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_28 PF13518.6 CCF37033.1 - 0.0012 18.9 0.4 0.0056 16.8 0.1 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_7 PF02796.15 CCF37033.1 - 0.005 16.9 0.6 0.0094 16.0 0.6 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_23 PF13384.6 CCF37033.1 - 0.0052 16.5 0.1 0.014 15.2 0.1 1.7 1 0 0 1 1 1 1 Homeodomain-like domain HTH_Tnp_IS630 PF01710.16 CCF37033.1 - 0.017 15.1 0.0 0.031 14.3 0.0 1.4 1 0 0 1 1 1 0 Transposase HTH_Tnp_ISL3 PF13542.6 CCF37033.1 - 0.042 13.3 0.0 0.084 12.3 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 HTH_8 PF02954.19 CCF37033.1 - 0.043 13.6 0.2 0.14 12.0 0.2 1.9 1 1 0 1 1 1 0 Bacterial regulatory protein, Fis family p450 PF00067.22 CCF37034.1 - 2.1e-44 152.1 0.0 2.5e-44 151.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 HisKA_2 PF07568.12 CCF37034.1 - 0.21 11.7 0.1 0.67 10.1 0.0 1.8 2 0 0 2 2 2 0 Histidine kinase FAD_binding_4 PF01565.23 CCF37035.1 - 4.8e-21 75.0 0.3 1.1e-20 73.8 0.3 1.7 1 0 0 1 1 1 1 FAD binding domain Nrap_D4 PF17405.2 CCF37036.1 - 2e-60 203.8 0.1 3.4e-60 203.1 0.1 1.3 1 0 0 1 1 1 1 Nrap protein nucleotidyltransferase domain 4 Nrap_D5 PF17406.2 CCF37036.1 - 8.8e-59 197.9 0.4 8.9e-58 194.6 0.4 2.3 2 0 0 2 2 2 1 Nrap protein PAP/OAS1-like domain 5 Nrap_D3 PF17404.2 CCF37036.1 - 6.6e-46 156.3 0.0 1.4e-45 155.2 0.0 1.6 1 0 0 1 1 1 1 Nrap protein domain 3 Nrap_D6 PF17407.2 CCF37036.1 - 2.5e-35 121.6 0.0 7.2e-35 120.1 0.0 1.8 1 0 0 1 1 1 1 Nrap protein domain 6 Nrap_D2 PF17403.2 CCF37036.1 - 1.9e-33 115.4 0.1 5e-30 104.3 0.0 2.5 2 0 0 2 2 2 2 Nrap protein PAP/OAS-like domain I-set PF07679.16 CCF37037.1 - 0.017 15.1 0.1 2.9 8.0 0.0 3.9 5 0 0 5 5 5 0 Immunoglobulin I-set domain PPTA PF01239.22 CCF37038.1 - 7.2e-35 117.7 19.3 7.8e-08 31.8 0.2 5.4 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat TPR_14 PF13428.6 CCF37038.1 - 0.078 13.8 3.3 0.44 11.5 1.0 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 CCF37038.1 - 0.14 12.7 2.8 19 5.9 1.3 3.5 2 1 1 3 3 3 0 Tetratricopeptide repeat GHMP_kinases_N PF00288.26 CCF37040.1 - 2e-17 63.2 0.0 4.8e-17 61.9 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 CCF37040.1 - 1.7e-08 34.7 0.0 4.1e-08 33.5 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal GalKase_gal_bdg PF10509.9 CCF37040.1 - 0.002 17.7 0.0 0.0051 16.3 0.0 1.7 1 0 0 1 1 1 1 Galactokinase galactose-binding signature Response_reg PF00072.24 CCF37041.1 - 3.5e-20 72.2 0.0 1.8e-19 70.0 0.0 2.1 2 0 0 2 2 2 1 Response regulator receiver domain HATPase_c PF02518.26 CCF37041.1 - 9e-20 71.3 0.0 1.6e-19 70.5 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Pro_isomerase PF00160.21 CCF37042.1 - 2.8e-50 170.7 0.9 3.3e-50 170.4 0.9 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Ribosomal_S13 PF00416.22 CCF37043.1 - 9.7e-16 58.3 0.2 2.1e-13 50.8 0.2 2.0 1 1 0 1 1 1 1 Ribosomal protein S13/S18 Peptidase_M19 PF01244.21 CCF37044.1 - 2.5e-102 342.3 0.0 2.9e-102 342.1 0.0 1.0 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) RhoGAP PF00620.27 CCF37045.1 - 7.4e-17 61.6 0.1 2.2e-16 60.0 0.0 1.8 2 0 0 2 2 2 1 RhoGAP domain DEP PF00610.21 CCF37045.1 - 1.8e-13 50.3 0.0 3.7e-13 49.3 0.0 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) FCH PF00611.23 CCF37045.1 - 2.1e-11 43.9 0.1 7.5e-11 42.2 0.0 2.0 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain BAR PF03114.18 CCF37045.1 - 0.014 15.1 0.6 0.043 13.4 0.6 1.8 1 0 0 1 1 1 0 BAR domain Med4 PF10018.9 CCF37045.1 - 0.03 14.0 1.5 0.087 12.5 0.0 2.5 2 0 0 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 MMS22L_C PF14911.6 CCF37045.1 - 0.041 13.0 0.0 0.069 12.2 0.0 1.2 1 0 0 1 1 1 0 S-phase genomic integrity recombination mediator, C-terminal DUF2951 PF11166.8 CCF37045.1 - 0.046 13.9 0.5 0.3 11.3 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2951) Adaptin_N PF01602.20 CCF37046.1 - 6.4e-67 226.3 0.0 1e-66 225.6 0.0 1.3 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 CCF37046.1 - 0.00013 22.0 0.0 0.0046 17.0 0.0 2.3 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 CCF37046.1 - 0.049 14.0 0.1 0.45 10.9 0.0 2.6 2 1 0 2 2 2 0 HEAT repeats CFEM PF05730.11 CCF37047.1 - 1.4e-06 28.3 5.2 2.2e-06 27.7 5.2 1.3 1 0 0 1 1 1 1 CFEM domain Condensation PF00668.20 CCF37048.1 - 0.029 13.1 0.1 0.082 11.6 0.0 1.7 2 0 0 2 2 2 0 Condensation domain DUF1676 PF07898.13 CCF37049.1 - 0.15 12.1 0.0 0.17 11.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1676) Skp1 PF01466.19 CCF37050.1 - 3.4e-30 103.9 0.4 4.2e-30 103.6 0.4 1.1 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Myb_DNA-binding PF00249.31 CCF37050.1 - 0.039 14.2 0.6 7.8 6.8 0.3 2.2 2 0 0 2 2 2 0 Myb-like DNA-binding domain Ribosomal_L39 PF00832.20 CCF37051.1 - 9.5e-23 79.6 8.7 1.1e-22 79.3 8.7 1.1 1 0 0 1 1 1 1 Ribosomal L39 protein Arf PF00025.21 CCF37052.1 - 1.1e-73 246.4 0.0 1.2e-73 246.3 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 CCF37052.1 - 1.2e-14 54.6 0.0 1.6e-14 54.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 CCF37052.1 - 1.5e-13 50.6 0.0 1.9e-13 50.3 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 CCF37052.1 - 4.4e-12 45.8 0.3 6.2e-08 32.2 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 CCF37052.1 - 5.5e-11 42.3 0.0 6.5e-11 42.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 CCF37052.1 - 2e-08 33.9 0.0 2.4e-08 33.6 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 CCF37052.1 - 7.1e-07 29.3 0.0 1.2e-06 28.6 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CCF37052.1 - 0.00018 21.1 0.0 0.015 14.8 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 CCF37052.1 - 0.01 15.4 0.8 0.045 13.3 0.8 1.9 1 1 0 1 1 1 0 Ferrous iron transport protein B Toprim_4 PF13662.6 CCF37052.1 - 0.072 13.6 0.0 1.5 9.4 0.0 2.3 2 0 0 2 2 2 0 Toprim domain AAA_18 PF13238.6 CCF37052.1 - 0.14 12.7 0.1 0.22 12.1 0.1 1.5 1 1 0 1 1 1 0 AAA domain HNH_repeat PF18780.1 CCF37052.1 - 0.2 11.5 0.5 0.33 10.8 0.5 1.4 1 0 0 1 1 1 0 Homing endonuclease repeat eIF-3_zeta PF05091.12 CCF37054.1 - 8.5e-13 48.1 0.0 8.5e-13 48.1 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) HTH_29 PF13551.6 CCF37055.1 - 7.3e-06 25.9 0.4 1.9e-05 24.6 0.4 1.6 1 1 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.6 CCF37055.1 - 8.9e-05 22.2 0.0 0.00011 21.9 0.0 1.1 1 0 0 1 1 1 1 Homeodomain-like domain HTH_32 PF13565.6 CCF37055.1 - 0.0056 17.3 0.1 0.22 12.2 0.0 2.2 1 1 1 2 2 2 1 Homeodomain-like domain Sigma70_r4_2 PF08281.12 CCF37055.1 - 0.014 15.1 0.1 0.019 14.6 0.1 1.3 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_28 PF13518.6 CCF37055.1 - 0.028 14.6 1.0 0.071 13.3 1.0 1.7 1 1 0 1 1 1 0 Helix-turn-helix domain HTH_10 PF04967.12 CCF37055.1 - 0.032 14.0 0.0 0.07 12.9 0.0 1.5 1 0 0 1 1 1 0 HTH DNA binding domain GerE PF00196.19 CCF37055.1 - 0.06 12.9 0.0 0.086 12.4 0.0 1.2 1 0 0 1 1 1 0 Bacterial regulatory proteins, luxR family MarR_2 PF12802.7 CCF37055.1 - 0.073 13.0 0.2 0.1 12.5 0.2 1.2 1 0 0 1 1 1 0 MarR family Helo_like_N PF17111.5 CCF37056.1 - 0.0014 18.0 0.0 0.0018 17.7 0.0 1.1 1 0 0 1 1 1 1 Fungal N-terminal domain of STAND proteins MMS1_N PF10433.9 CCF37057.1 - 5.3e-58 196.9 0.0 2.3e-57 194.7 0.0 2.0 2 0 0 2 2 2 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 CCF37057.1 - 0.088 12.1 0.0 3.6 6.8 0.0 3.0 4 0 0 4 4 4 0 CPSF A subunit region Rad21_Rec8_N PF04825.13 CCF37058.1 - 3.3e-37 127.0 0.0 6e-37 126.2 0.0 1.4 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.16 CCF37058.1 - 4.8e-09 35.4 0.0 9.3e-09 34.4 0.0 1.5 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein HSP20 PF00011.21 CCF37059.1 - 5.4e-11 42.6 0.0 6.7e-11 42.2 0.0 1.1 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 CCF37059.1 - 0.0047 16.5 0.0 0.15 11.7 0.0 2.7 1 1 0 1 1 1 1 HSP20-like domain found in ArsA Glyco_hydro_61 PF03443.14 CCF37060.1 - 3e-41 141.6 0.1 3.4e-41 141.5 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 DUF1593 PF07632.11 CCF37061.1 - 5.1e-94 314.5 0.0 6.4e-94 314.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1593) Root_cap PF06830.11 CCF37061.1 - 0.11 12.6 0.0 0.34 11.1 0.0 1.8 1 0 0 1 1 1 0 Root cap TLD PF07534.16 CCF37062.1 - 2.9e-25 89.1 0.0 3.9e-13 49.8 0.0 2.5 3 0 0 3 3 3 2 TLD DUF1856 PF08983.10 CCF37062.1 - 0.15 12.3 3.8 0.38 11.0 3.8 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1856) Pkinase PF00069.25 CCF37063.1 - 5.7e-68 229.1 0.0 7.5e-68 228.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF37063.1 - 5.8e-32 111.0 0.0 7.6e-32 110.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CCF37063.1 - 0.00034 20.0 0.3 0.00056 19.3 0.3 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 CCF37063.1 - 0.0011 18.0 0.2 0.0018 17.3 0.2 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 CCF37063.1 - 0.0078 15.6 0.0 0.013 14.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 CCF37063.1 - 0.026 14.5 0.0 0.039 13.9 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 CCF37063.1 - 0.058 12.4 0.0 0.089 11.8 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Gag_p6 PF08705.11 CCF37063.1 - 0.1 12.9 0.1 0.2 11.9 0.1 1.4 1 0 0 1 1 1 0 Gag protein p6 S_100 PF01023.19 CCF37063.1 - 0.13 12.0 0.2 0.38 10.5 0.2 1.8 1 0 0 1 1 1 0 S-100/ICaBP type calcium binding domain SDA1 PF05285.12 CCF37067.1 - 1.7e-92 310.6 46.2 1.7e-92 310.6 46.2 2.8 2 1 0 2 2 2 2 SDA1 NUC130_3NT PF08158.12 CCF37067.1 - 8.8e-19 67.6 0.2 2.5e-18 66.1 0.2 1.9 1 0 0 1 1 1 1 NUC130/3NT domain YL1 PF05764.13 CCF37067.1 - 1.7 8.7 39.4 0.95 9.5 1.3 2.5 2 0 0 2 2 2 0 YL1 nuclear protein DZR PF12773.7 CCF37068.1 - 0.00063 19.7 26.0 0.035 14.1 9.7 4.0 4 0 0 4 4 4 2 Double zinc ribbon FhuF_C PF11575.8 CCF37068.1 - 0.0067 16.3 0.5 0.0067 16.3 0.5 4.7 6 0 0 6 6 6 1 FhuF 2Fe-2S C-terminal domain YhfH PF14149.6 CCF37068.1 - 0.034 14.1 0.1 0.034 14.1 0.1 3.6 5 0 0 5 5 5 0 YhfH-like protein FAD_binding_3 PF01494.19 CCF37069.1 - 2.7e-12 46.6 0.2 4.8e-12 45.8 0.1 1.4 1 1 0 1 1 1 1 FAD binding domain Tir_receptor_C PF07489.11 CCF37069.1 - 0.098 12.6 4.8 0.15 12.0 4.8 1.3 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus FSA_C PF10479.9 CCF37069.1 - 0.29 9.2 4.2 0.38 8.8 4.2 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus DUF3439 PF11921.8 CCF37069.1 - 0.41 10.6 11.9 0.8 9.7 11.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Dicty_REP PF05086.12 CCF37069.1 - 0.74 7.7 5.4 0.96 7.4 5.4 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein SSP160 PF06933.11 CCF37069.1 - 0.84 7.8 18.5 1.2 7.3 18.5 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Mucin PF01456.17 CCF37069.1 - 2.4 8.2 20.6 0.53 10.3 17.4 1.5 2 0 0 2 2 2 0 Mucin-like glycoprotein CAP PF00188.26 CCF37070.1 - 2.4e-18 67.2 0.2 3.9e-18 66.5 0.2 1.3 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Peptidase_C2 PF00648.21 CCF37071.1 - 8e-06 25.1 0.0 8.9e-06 24.9 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease Peptidase_C1 PF00112.23 CCF37071.1 - 0.027 14.6 0.1 0.03 14.4 0.1 1.1 1 0 0 1 1 1 0 Papain family cysteine protease MR_MLE_C PF13378.6 CCF37072.1 - 5.3e-48 163.5 0.2 6.7e-48 163.1 0.2 1.1 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 CCF37072.1 - 0.035 14.3 0.1 0.075 13.2 0.1 1.7 1 1 0 1 1 1 0 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain Sugar_tr PF00083.24 CCF37073.1 - 3.2e-94 316.3 18.2 3.7e-94 316.2 18.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF37073.1 - 1.3e-40 139.5 40.5 1.4e-34 119.6 21.6 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 CCF37073.1 - 2.4e-06 26.3 10.3 0.0002 19.9 2.1 2.2 2 0 0 2 2 2 2 Fungal trichothecene efflux pump (TRI12) FA_desaturase PF00487.24 CCF37074.1 - 6.7e-24 85.1 21.2 1.5e-23 84.0 21.2 1.6 1 1 0 1 1 1 1 Fatty acid desaturase DUF3474 PF11960.8 CCF37074.1 - 7.6e-08 32.6 0.0 1.1e-06 28.9 0.0 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF3474) BES1_N PF05687.13 CCF37074.1 - 6.5 7.1 5.4 13 6.2 5.4 1.4 1 0 0 1 1 1 0 BES1/BZR1 plant transcription factor, N-terminal HET PF06985.11 CCF37075.1 - 3.4e-09 37.2 0.0 6.9e-09 36.2 0.0 1.5 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) SLAC1 PF03595.17 CCF37076.1 - 6.5e-85 285.2 37.1 7.5e-85 285.0 37.1 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel LemA PF04011.12 CCF37077.1 - 0.018 14.9 1.1 0.021 14.7 1.1 1.3 1 1 0 1 1 1 0 LemA family DUF4874 PF16173.5 CCF37077.1 - 0.053 13.2 0.2 0.06 13.0 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4874) DUF1843 PF08898.10 CCF37077.1 - 0.12 12.9 0.7 0.18 12.3 0.4 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF1843) DUF4407 PF14362.6 CCF37077.1 - 0.75 9.1 3.5 0.79 9.0 3.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) MFS_1 PF07690.16 CCF37078.1 - 1.2e-16 60.6 49.7 2e-09 36.9 16.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1 PF07690.16 CCF37079.1 - 1.1e-19 70.7 40.9 1.1e-19 70.7 40.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Ferric_reduct PF01794.19 CCF37080.1 - 4.2e-21 75.3 12.1 1.3e-20 73.8 12.1 1.9 1 0 0 1 1 1 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 CCF37080.1 - 2.4e-06 27.8 0.1 0.016 15.3 0.0 2.3 1 1 1 2 2 2 2 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 CCF37080.1 - 0.00031 20.8 0.0 0.00075 19.6 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_1 PF00175.21 CCF37080.1 - 0.085 13.5 0.3 0.47 11.1 0.3 2.1 1 1 0 1 1 1 0 Oxidoreductase NAD-binding domain Rcd1 PF04078.13 CCF37081.1 - 7.4e-126 418.7 5.3 9.5e-126 418.4 5.3 1.1 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like DUF2722 PF10846.8 CCF37081.1 - 0.00013 21.1 7.9 0.00016 20.8 7.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) TFIIA PF03153.13 CCF37081.1 - 0.0037 17.3 21.8 0.005 16.9 21.8 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit RskA PF10099.9 CCF37081.1 - 0.005 17.2 4.9 0.0093 16.3 4.9 1.4 1 0 0 1 1 1 1 Anti-sigma-K factor rskA eIF-3_zeta PF05091.12 CCF37081.1 - 0.34 9.8 9.5 0.46 9.4 9.5 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) PAT1 PF09770.9 CCF37081.1 - 0.48 8.6 15.4 0.61 8.3 15.4 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Med15 PF09606.10 CCF37081.1 - 0.52 8.9 25.5 0.68 8.6 25.5 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal UPF0560 PF10577.9 CCF37081.1 - 0.67 8.4 14.7 0.87 8.0 14.7 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Connexin PF00029.19 CCF37081.1 - 1 9.1 4.1 1.7 8.3 4.1 1.4 1 0 0 1 1 1 0 Connexin Kei1 PF08552.11 CCF37081.1 - 1.3 8.9 5.5 2.3 8.1 5.5 1.5 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 PepSY_TM PF03929.16 CCF37081.1 - 1.5 8.4 4.3 2.2 7.9 4.3 1.2 1 0 0 1 1 1 0 PepSY-associated TM region Otopetrin PF03189.13 CCF37081.1 - 1.7 7.4 6.0 0.12 11.2 1.1 1.5 2 0 0 2 2 2 0 Otopetrin Androgen_recep PF02166.16 CCF37081.1 - 2.6 6.8 23.9 3.7 6.3 23.9 1.2 1 0 0 1 1 1 0 Androgen receptor CCDC53 PF10152.9 CCF37081.1 - 3.1 8.2 11.1 6.7 7.1 11.1 1.5 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Suf PF05843.14 CCF37081.1 - 3.9 7.4 11.7 5.8 6.8 11.7 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Spore_coat_CotO PF14153.6 CCF37081.1 - 3.9 7.4 14.7 6.4 6.7 14.7 1.3 1 0 0 1 1 1 0 Spore coat protein CotO Roughex PF06020.11 CCF37081.1 - 4.4 6.3 8.5 5.9 5.9 8.5 1.2 1 0 0 1 1 1 0 Drosophila roughex protein Presenilin PF01080.17 CCF37081.1 - 4.4 6.0 12.0 6.5 5.4 12.0 1.2 1 0 0 1 1 1 0 Presenilin Band_3_cyto PF07565.13 CCF37081.1 - 5.3 6.8 10.3 2 8.1 7.0 1.9 2 0 0 2 2 2 0 Band 3 cytoplasmic domain Plasmodium_Vir PF05795.11 CCF37081.1 - 5.9 6.2 6.6 8.3 5.7 6.6 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Pex14_N PF04695.13 CCF37081.1 - 9 6.9 18.7 17 6.0 18.7 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Pkinase PF00069.25 CCF37082.1 - 1.3e-56 191.9 0.0 1.8e-56 191.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF37082.1 - 1e-31 110.2 0.0 1.5e-31 109.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.19 CCF37082.1 - 2.8e-20 71.8 0.3 5.2e-20 71.0 0.3 1.5 1 0 0 1 1 1 1 Kinase associated domain 1 Kdo PF06293.14 CCF37082.1 - 1.9e-05 24.1 0.1 3.9e-05 23.1 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 CCF37082.1 - 5.1e-05 22.7 0.0 8e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 CCF37082.1 - 0.00022 20.3 0.1 0.00033 19.7 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 CCF37082.1 - 0.0033 17.4 0.0 0.0076 16.2 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family SDP_N PF12278.8 CCF37082.1 - 0.017 15.3 3.7 0.07 13.3 0.6 2.5 2 0 0 2 2 2 0 Sex determination protein N terminal RIO1 PF01163.22 CCF37082.1 - 0.037 13.6 1.2 0.12 12.0 0.1 2.1 2 0 0 2 2 2 0 RIO1 family YrbL-PhoP_reg PF10707.9 CCF37082.1 - 0.067 12.7 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Choline_kinase PF01633.20 CCF37082.1 - 0.16 11.5 0.6 0.42 10.2 0.6 1.5 1 1 1 2 2 2 0 Choline/ethanolamine kinase AAA_18 PF13238.6 CCF37083.1 - 4e-11 43.6 0.1 4.1e-10 40.3 0.1 2.7 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 CCF37083.1 - 3.8e-09 36.8 0.0 5.2e-09 36.4 0.0 1.2 1 0 0 1 1 1 1 AAA domain SKI PF01202.22 CCF37083.1 - 2e-08 34.5 0.0 2.3e-08 34.3 0.0 1.2 1 0 0 1 1 1 1 Shikimate kinase AAA_16 PF13191.6 CCF37083.1 - 7.8e-06 26.4 0.0 1.3e-05 25.6 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 CCF37083.1 - 4.4e-05 23.8 0.1 0.00011 22.5 0.1 1.8 2 1 0 2 2 1 1 AAA domain AAA PF00004.29 CCF37083.1 - 8.8e-05 22.9 0.0 0.00015 22.2 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CCF37083.1 - 0.00095 19.2 0.0 0.0018 18.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 CCF37083.1 - 0.0011 18.5 0.1 0.0018 17.9 0.1 1.2 1 0 0 1 1 1 1 P-loop containing dynein motor region CPT PF07931.12 CCF37083.1 - 0.0014 18.5 0.2 0.0072 16.2 0.0 2.1 2 1 0 2 2 2 1 Chloramphenicol phosphotransferase-like protein Zeta_toxin PF06414.12 CCF37083.1 - 0.0017 17.7 0.0 0.0031 16.8 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin APS_kinase PF01583.20 CCF37083.1 - 0.0017 18.3 0.0 0.0028 17.6 0.0 1.4 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_17 PF13207.6 CCF37083.1 - 0.0024 18.3 0.0 0.0064 16.9 0.0 1.7 1 1 0 1 1 1 1 AAA domain NTPase_1 PF03266.15 CCF37083.1 - 0.0024 17.8 0.7 0.0055 16.6 0.5 1.6 2 0 0 2 2 2 1 NTPase Rad17 PF03215.15 CCF37083.1 - 0.0026 17.7 0.0 0.0039 17.2 0.0 1.3 1 0 0 1 1 1 1 Rad17 P-loop domain ABC_tran PF00005.27 CCF37083.1 - 0.0026 18.3 0.0 0.0037 17.8 0.0 1.2 1 0 0 1 1 1 1 ABC transporter TsaE PF02367.17 CCF37083.1 - 0.0037 17.3 0.0 0.0056 16.7 0.0 1.2 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_30 PF13604.6 CCF37083.1 - 0.0041 16.9 0.0 0.007 16.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 CCF37083.1 - 0.0047 17.2 1.6 0.01 16.1 1.6 1.9 1 1 0 1 1 1 1 AAA domain T2SSE PF00437.20 CCF37083.1 - 0.0049 16.0 0.1 0.0081 15.2 0.1 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein RNA_helicase PF00910.22 CCF37083.1 - 0.0052 17.2 0.0 0.0074 16.7 0.0 1.2 1 0 0 1 1 1 1 RNA helicase PhoH PF02562.16 CCF37083.1 - 0.0057 16.1 0.0 0.0087 15.5 0.0 1.2 1 0 0 1 1 1 1 PhoH-like protein Cytidylate_kin PF02224.18 CCF37083.1 - 0.0057 16.4 0.0 0.0076 16.0 0.0 1.2 1 0 0 1 1 1 1 Cytidylate kinase NB-ARC PF00931.22 CCF37083.1 - 0.0061 15.8 0.0 0.011 15.0 0.0 1.4 2 0 0 2 2 1 1 NB-ARC domain AAA_14 PF13173.6 CCF37083.1 - 0.0063 16.6 0.0 0.011 15.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 CCF37083.1 - 0.0074 15.9 0.2 0.018 14.6 0.0 1.7 1 1 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 CCF37083.1 - 0.0085 15.5 0.0 0.013 14.9 0.0 1.2 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_23 PF13476.6 CCF37083.1 - 0.0095 16.5 0.0 0.013 16.0 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 CCF37083.1 - 0.014 15.1 0.0 0.017 14.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain Ploopntkinase3 PF18751.1 CCF37083.1 - 0.016 15.1 0.0 0.024 14.5 0.0 1.2 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 AAA_19 PF13245.6 CCF37083.1 - 0.018 15.4 0.1 0.031 14.6 0.1 1.3 1 0 0 1 1 1 0 AAA domain CoaE PF01121.20 CCF37083.1 - 0.021 14.5 0.0 0.043 13.5 0.0 1.5 1 0 0 1 1 1 0 Dephospho-CoA kinase ATPase_2 PF01637.18 CCF37083.1 - 0.022 14.7 0.0 0.032 14.1 0.0 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea ResIII PF04851.15 CCF37083.1 - 0.034 14.1 0.1 0.057 13.4 0.1 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Sigma54_activat PF00158.26 CCF37083.1 - 0.041 13.6 0.0 0.084 12.6 0.0 1.4 2 0 0 2 2 1 0 Sigma-54 interaction domain Sigma54_activ_2 PF14532.6 CCF37083.1 - 0.047 13.8 0.0 0.087 12.9 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain NACHT PF05729.12 CCF37083.1 - 0.048 13.6 0.0 0.078 12.9 0.0 1.3 1 0 0 1 1 1 0 NACHT domain AAA_29 PF13555.6 CCF37083.1 - 0.055 13.2 0.0 0.1 12.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CCF37083.1 - 0.057 13.3 0.0 0.08 12.8 0.0 1.2 1 0 0 1 1 1 0 RsgA GTPase ATPase PF06745.13 CCF37083.1 - 0.061 12.7 0.0 0.098 12.0 0.0 1.2 1 0 0 1 1 1 0 KaiC DUF2075 PF09848.9 CCF37083.1 - 0.075 12.3 0.0 0.095 11.9 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) RuvB_N PF05496.12 CCF37083.1 - 0.092 12.5 0.0 0.15 11.8 0.0 1.2 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 CCF37083.1 - 0.1 12.7 0.0 0.14 12.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) cobW PF02492.19 CCF37083.1 - 0.11 12.0 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain PIF1 PF05970.14 CCF37083.1 - 0.12 11.6 0.0 0.17 11.0 0.0 1.1 1 0 0 1 1 1 0 PIF1-like helicase IstB_IS21 PF01695.17 CCF37083.1 - 0.12 12.1 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_11 PF13086.6 CCF37083.1 - 0.14 11.9 0.0 0.2 11.4 0.0 1.1 1 0 0 1 1 1 0 AAA domain AAA_PrkA PF08298.11 CCF37083.1 - 0.15 10.9 0.0 0.2 10.5 0.0 1.1 1 0 0 1 1 1 0 PrkA AAA domain PduV-EutP PF10662.9 CCF37083.1 - 0.18 11.5 0.1 0.28 10.9 0.1 1.2 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Cytidylate_kin2 PF13189.6 CCF37083.1 - 0.18 11.9 0.0 0.65 10.1 0.0 1.8 2 0 0 2 2 2 0 Cytidylate kinase-like family dNK PF01712.19 CCF37083.1 - 0.19 11.5 0.0 0.35 10.7 0.0 1.5 1 1 0 1 1 1 0 Deoxynucleoside kinase AAA_6 PF12774.7 CCF37083.1 - 0.21 10.5 0.0 0.27 10.1 0.0 1.1 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region TrwB_AAD_bind PF10412.9 CCF37083.1 - 0.22 10.4 0.1 0.3 9.9 0.1 1.1 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain Aldedh PF00171.22 CCF37084.1 - 9.3e-44 149.7 0.1 1.1e-43 149.4 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 CCF37084.1 - 0.2 11.1 0.0 0.3 10.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1487) Methyltransf_23 PF13489.6 CCF37086.1 - 8e-19 68.1 0.0 1.4e-18 67.3 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF37086.1 - 5.6e-11 43.0 0.0 1.2e-10 42.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF37086.1 - 4.7e-08 33.0 0.0 3.9e-07 30.0 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF37086.1 - 4e-07 30.6 0.0 1.1e-06 29.2 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF37086.1 - 3.6e-06 27.6 0.0 1.3e-05 25.9 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CCF37086.1 - 0.0088 15.6 0.0 0.015 14.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.18 CCF37086.1 - 0.023 14.0 0.0 1.2 8.4 0.0 2.2 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 CCF37086.1 - 0.056 12.9 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_2 PF00891.18 CCF37086.1 - 0.11 11.8 0.0 0.36 10.1 0.0 1.8 2 0 0 2 2 2 0 O-methyltransferase domain FtsJ PF01728.19 CCF37086.1 - 0.18 11.9 0.0 0.32 11.1 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase zf-MYND PF01753.18 CCF37088.1 - 9.4e-11 41.6 13.6 1.4e-10 41.1 13.6 1.3 1 0 0 1 1 1 1 MYND finger LSM PF01423.22 CCF37089.1 - 1.4e-17 63.1 0.0 1.9e-17 62.7 0.0 1.2 1 0 0 1 1 1 1 LSM domain Ribosomal_L5 PF00281.19 CCF37090.1 - 8.5e-19 67.7 0.1 2e-18 66.5 0.0 1.5 2 0 0 2 2 2 1 Ribosomal protein L5 Tti2 PF10521.9 CCF37091.1 - 3.1e-68 230.4 0.3 4.6e-68 229.8 0.3 1.2 1 0 0 1 1 1 1 Tti2 family Syja_N PF02383.18 CCF37092.1 - 2.4e-75 253.8 0.0 6.2e-75 252.5 0.0 1.7 2 0 0 2 2 2 1 SacI homology domain HD_6 PF18019.1 CCF37092.1 - 0.15 12.2 0.9 0.58 10.2 0.1 2.1 2 0 0 2 2 2 0 HD domain DBR1 PF05011.13 CCF37093.1 - 5.9e-35 120.7 2.3 2.5e-34 118.7 0.0 2.2 1 1 1 2 2 2 1 Lariat debranching enzyme, C-terminal domain Metallophos PF00149.28 CCF37093.1 - 2.4e-05 25.0 0.1 3.4e-05 24.4 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase CDC45 PF02724.14 CCF37093.1 - 0.066 11.5 0.2 0.097 10.9 0.2 1.2 1 0 0 1 1 1 0 CDC45-like protein Abhydrolase_6 PF12697.7 CCF37094.1 - 2.4e-16 61.0 3.8 3.9e-16 60.3 3.8 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCF37094.1 - 4.1e-15 55.7 1.0 7.8e-15 54.8 1.0 1.5 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CCF37094.1 - 3.8e-12 46.4 1.5 1.6e-10 41.1 1.5 2.1 2 0 0 2 2 2 1 alpha/beta hydrolase fold Thioesterase PF00975.20 CCF37094.1 - 1e-06 29.0 0.8 2.1e-06 28.0 0.8 1.4 1 1 1 2 2 2 1 Thioesterase domain PGAP1 PF07819.13 CCF37094.1 - 0.00019 21.2 0.6 0.0022 17.7 0.6 2.3 2 1 0 2 2 2 1 PGAP1-like protein Peptidase_S9 PF00326.21 CCF37094.1 - 0.00073 19.1 0.6 0.0077 15.7 0.2 2.5 3 0 0 3 3 3 1 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 CCF37094.1 - 0.00074 19.4 0.1 0.0016 18.3 0.1 1.6 1 0 0 1 1 1 1 alpha/beta hydrolase fold Lipase_2 PF01674.18 CCF37094.1 - 0.0042 16.6 0.0 0.0064 16.0 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 2) AXE1 PF05448.12 CCF37094.1 - 0.012 14.3 0.8 2.4 6.7 0.1 2.8 2 1 1 3 3 3 0 Acetyl xylan esterase (AXE1) Eno-Rase_NADH_b PF12242.8 CCF37094.1 - 0.015 15.0 0.5 0.062 13.1 0.1 2.0 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Lipase_3 PF01764.25 CCF37094.1 - 0.047 13.6 0.1 0.077 12.9 0.1 1.3 1 0 0 1 1 1 0 Lipase (class 3) DUF1100 PF06500.11 CCF37094.1 - 0.085 11.6 0.0 0.12 11.2 0.0 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1100) LIDHydrolase PF10230.9 CCF37094.1 - 0.14 11.7 0.0 0.22 11.0 0.0 1.3 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase DUF2974 PF11187.8 CCF37094.1 - 0.18 11.3 0.3 0.36 10.3 0.1 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) LSM PF01423.22 CCF37095.1 - 1e-18 66.8 0.1 1.3e-18 66.4 0.1 1.1 1 0 0 1 1 1 1 LSM domain PRMT5_C PF17286.2 CCF37096.1 - 3.5e-31 108.4 1.7 3.8e-31 108.3 1.7 1.0 1 0 0 1 1 1 1 PRMT5 oligomerisation domain AA_permease_2 PF13520.6 CCF37097.1 - 1.1e-58 199.1 34.4 2.9e-55 187.8 23.5 2.1 1 1 1 2 2 2 2 Amino acid permease AA_permease PF00324.21 CCF37097.1 - 4.4e-20 71.7 19.6 4.4e-20 71.7 19.6 1.5 1 1 1 2 2 2 1 Amino acid permease Aa_trans PF01490.18 CCF37097.1 - 0.00053 18.8 10.8 0.003 16.4 10.8 2.0 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein TRAP-delta PF05404.12 CCF37100.1 - 0.11 12.0 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 Translocon-associated protein, delta subunit precursor (TRAP-delta) Sugar_tr PF00083.24 CCF37101.1 - 5.7e-10 38.6 2.2 7.2e-10 38.3 2.2 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF37101.1 - 1.3e-08 34.2 8.0 1.3e-08 34.2 8.0 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily Saf_2TM PF18303.1 CCF37101.1 - 0.027 14.0 0.0 1 8.9 0.0 2.4 2 0 0 2 2 2 0 SAVED-fused 2TM effector domain NiFe_hyd_3_EhaA PF17367.2 CCF37101.1 - 4.4 7.5 7.7 26 5.1 0.2 3.4 4 0 0 4 4 4 0 NiFe-hydrogenase-type-3 Eha complex subunit A Glyco_hydro_125 PF06824.11 CCF37105.1 - 4.9e-178 592.3 0.0 5.6e-178 592.1 0.0 1.0 1 0 0 1 1 1 1 Metal-independent alpha-mannosidase (GH125) zf-C3HC4_3 PF13920.6 CCF37106.1 - 0.00073 19.4 11.8 0.0011 18.7 11.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Defensin_propep PF00879.18 CCF37106.1 - 0.31 11.4 2.1 1.1 9.5 2.1 2.1 1 0 0 1 1 1 0 Defensin propeptide zf-RING_6 PF14835.6 CCF37106.1 - 0.38 10.7 7.5 0.72 9.8 7.5 1.3 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Prok-RING_4 PF14447.6 CCF37106.1 - 6.4 6.7 12.8 11 5.9 12.8 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Ras PF00071.22 CCF37107.1 - 8.8e-58 194.5 0.0 1e-57 194.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCF37107.1 - 3.2e-34 117.7 0.0 4.9e-34 117.1 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCF37107.1 - 2.6e-14 53.1 0.0 4.5e-14 52.3 0.0 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 CCF37107.1 - 3.7e-06 26.6 0.0 5.9e-06 25.9 0.0 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 CCF37107.1 - 3.1e-05 23.5 0.0 3.9e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 CCF37107.1 - 7.8e-05 22.7 0.0 0.00013 22.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 CCF37107.1 - 0.00077 19.9 0.1 0.0012 19.2 0.1 1.5 1 1 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 CCF37107.1 - 0.021 14.8 0.1 2 8.3 0.0 2.3 2 1 0 2 2 2 0 RsgA GTPase AAA_22 PF13401.6 CCF37107.1 - 0.17 12.2 0.0 1.3 9.3 0.0 2.1 2 1 0 2 2 2 0 AAA domain Dynamin_N PF00350.23 CCF37109.1 - 2.1e-35 122.3 0.1 3.7e-35 121.5 0.1 1.4 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 CCF37109.1 - 5.2e-24 85.0 0.0 2.9e-22 79.2 0.0 2.3 1 1 0 1 1 1 1 Dynamin central region GED PF02212.18 CCF37109.1 - 2.2e-05 24.5 1.7 3e-05 24.1 0.2 1.9 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 CCF37109.1 - 0.0015 18.6 0.5 0.019 15.0 0.5 2.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 CCF37109.1 - 0.074 12.4 0.1 3.8 6.8 0.1 2.4 2 0 0 2 2 2 0 AIG1 family FeoB_N PF02421.18 CCF37109.1 - 0.076 12.5 0.1 6.4 6.3 0.1 2.3 2 0 0 2 2 2 0 Ferrous iron transport protein B LMBR1 PF04791.16 CCF37110.1 - 4.3e-17 62.2 5.0 4.3e-17 62.2 5.0 1.4 1 1 1 2 2 2 1 LMBR1-like membrane protein TMEM208_SND2 PF05620.11 CCF37110.1 - 0.64 9.8 0.0 0.64 9.8 0.0 3.2 4 0 0 4 4 4 0 SRP-independent targeting protein 2/TMEM208 TMEM220 PF15071.6 CCF37110.1 - 0.98 10.2 7.8 28 5.5 5.3 3.9 3 1 0 3 3 3 0 Transmembrane family 220, helix MMS1_N PF10433.9 CCF37111.1 - 2.5e-16 59.4 0.0 6.6e-16 58.0 0.0 1.6 1 1 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term RRN9 PF10680.9 CCF37112.1 - 0.089 13.1 0.0 0.1 12.9 0.0 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor Fungal_trans PF04082.18 CCF37113.1 - 2.1e-05 23.7 0.1 3.7e-05 22.9 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF37114.1 - 1.1e-08 35.1 7.8 2.2e-08 34.1 7.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Trypan_PARP PF05887.11 CCF37114.1 - 9.7e-06 25.6 17.7 9.7e-06 25.6 17.7 2.8 3 0 0 3 3 3 1 Procyclic acidic repetitive protein (PARP) DUF2235 PF09994.9 CCF37115.1 - 1.1e-84 284.2 0.0 2e-84 283.4 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) Zn_clus PF00172.18 CCF37116.1 - 2.1e-08 34.1 5.7 3.4e-08 33.5 5.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SSXRD PF09514.10 CCF37116.1 - 0.64 9.6 2.8 1.6 8.4 0.6 2.3 2 0 0 2 2 2 0 SSXRD motif DNA_methylase PF00145.17 CCF37118.1 - 0.17 11.2 0.0 0.27 10.5 0.0 1.3 1 0 0 1 1 1 0 C-5 cytosine-specific DNA methylase PhoD PF09423.10 CCF37119.1 - 5.3e-43 147.4 0.0 8.9e-43 146.6 0.0 1.3 1 0 0 1 1 1 1 PhoD-like phosphatase EMP24_GP25L PF01105.24 CCF37120.1 - 2.7e-46 157.8 1.3 3.2e-46 157.6 1.3 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Chromo PF00385.24 CCF37121.1 - 0.06 13.3 0.7 0.2 11.6 0.7 1.9 1 0 0 1 1 1 0 Chromo (CHRromatin Organisation MOdifier) domain Pox_A_type_inc PF04508.12 CCF37121.1 - 0.96 9.4 3.3 4.3 7.4 0.2 3.3 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat PKcGMP_CC PF16808.5 CCF37121.1 - 1.6 8.7 9.4 3.8 7.4 0.7 3.9 3 1 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase COX5A PF02284.16 CCF37122.1 - 2.6e-40 136.6 0.2 3.4e-40 136.2 0.2 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Va GTP_EFTU PF00009.27 CCF37123.1 - 3.8e-19 69.0 0.0 6.1e-19 68.3 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 CCF37123.1 - 6.6e-10 39.2 0.7 4.1e-09 36.7 0.5 2.4 2 0 0 2 2 2 1 Elongation factor Tu domain 2 GTP_EFTU_D3 PF03143.17 CCF37123.1 - 0.0001 22.6 0.1 0.00026 21.3 0.1 1.7 1 1 0 1 1 1 1 Elongation factor Tu C-terminal domain MMR_HSR1 PF01926.23 CCF37123.1 - 0.0011 19.1 0.1 0.0036 17.4 0.1 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.9 CCF37123.1 - 0.0041 16.9 0.2 0.7 9.6 0.1 3.2 2 1 1 3 3 3 1 Ethanolamine utilisation - propanediol utilisation RsgA_GTPase PF03193.16 CCF37123.1 - 0.0066 16.4 0.3 2.1 8.2 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase Dynamin_N PF00350.23 CCF37123.1 - 0.06 13.4 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 Dynamin family Roc PF08477.13 CCF37123.1 - 0.1 12.8 0.1 0.86 9.8 0.0 2.3 1 1 1 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Hexapep PF00132.24 CCF37124.1 - 6e-08 32.1 3.0 0.00086 18.9 0.5 3.7 1 1 3 4 4 4 4 Bacterial transferase hexapeptide (six repeats) DUF4954 PF16314.5 CCF37124.1 - 3.7e-05 22.1 1.2 5.2e-05 21.6 0.9 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4954) Fucokinase PF07959.12 CCF37124.1 - 5.3e-05 22.3 0.2 5.8e-05 22.2 0.2 1.1 1 0 0 1 1 1 1 L-fucokinase Hexapep_2 PF14602.6 CCF37124.1 - 0.0026 17.4 6.2 0.038 13.7 0.2 3.7 3 1 0 3 3 3 1 Hexapeptide repeat of succinyl-transferase Ifi-6-16 PF06140.13 CCF37125.1 - 2.9e-14 52.7 7.5 3.1e-11 43.0 2.5 2.2 2 0 0 2 2 2 2 Interferon-induced 6-16 family DUF883 PF05957.13 CCF37125.1 - 0.012 16.2 0.1 0.049 14.2 0.0 1.8 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF883) Promethin PF16015.5 CCF37125.1 - 0.036 14.0 4.1 0.065 13.2 4.1 1.4 1 0 0 1 1 1 0 Promethin Flagellar_rod PF05149.12 CCF37125.1 - 0.2 11.1 0.0 0.24 10.8 0.0 1.1 1 0 0 1 1 1 0 Paraflagellar rod protein OppC_N PF12911.7 CCF37125.1 - 0.94 9.5 3.9 17 5.5 0.9 2.4 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C Syndecan PF01034.20 CCF37129.1 - 0.12 12.3 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 Syndecan domain He_PIG PF05345.12 CCF37130.1 - 2.4e-14 53.2 11.3 0.00017 21.7 0.2 4.9 4 0 0 4 4 4 3 Putative Ig domain Cadherin_C_2 PF16492.5 CCF37130.1 - 0.00038 21.1 0.2 0.002 18.8 0.0 2.2 2 0 0 2 2 2 1 Cadherin cytoplasmic C-terminal BatD PF13584.6 CCF37130.1 - 0.0056 15.6 0.0 0.0094 14.8 0.0 1.3 1 0 0 1 1 1 1 Oxygen tolerance TMEM154 PF15102.6 CCF37130.1 - 0.012 15.5 0.6 0.012 15.5 0.6 2.2 2 1 0 2 2 2 0 TMEM154 protein family DUF4448 PF14610.6 CCF37130.1 - 0.027 14.3 0.0 0.047 13.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) Herpes_gE PF02480.16 CCF37130.1 - 0.07 11.9 0.0 0.11 11.2 0.0 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E EphA2_TM PF14575.6 CCF37130.1 - 0.077 13.9 0.0 0.19 12.6 0.0 1.7 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Ly49 PF08391.10 CCF37130.1 - 0.23 11.8 0.1 0.46 10.9 0.1 1.4 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region Methyltransf_16 PF10294.9 CCF37131.1 - 1.9e-39 135.2 0.0 8.2e-39 133.1 0.0 1.8 1 1 0 1 1 1 1 Lysine methyltransferase KH_1 PF00013.29 CCF37133.1 - 8.1e-08 32.0 0.1 2.2e-07 30.6 0.0 1.7 2 0 0 2 2 2 1 KH domain DUF974 PF06159.13 CCF37134.1 - 3.6e-82 275.9 0.0 4.3e-82 275.6 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF974) Ank PF00023.30 CCF37135.1 - 7.4e-14 51.5 0.2 0.00098 19.5 0.0 3.3 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.6 CCF37135.1 - 8.8e-13 48.5 0.0 0.00011 22.7 0.0 3.5 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 CCF37135.1 - 2.6e-11 43.9 0.1 0.00014 22.4 0.0 3.0 2 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CCF37135.1 - 4.2e-10 39.0 0.2 0.00093 19.5 0.0 4.1 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 CCF37135.1 - 3.2e-07 30.5 1.3 0.087 13.2 0.0 3.5 4 0 0 4 4 4 2 Ankyrin repeats (many copies) OPT PF03169.15 CCF37136.1 - 7.2e-44 150.4 2.1 8.5e-44 150.2 2.1 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DAO PF01266.24 CCF37137.1 - 8.9e-36 124.2 0.1 1.1e-35 123.9 0.1 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CCF37137.1 - 5e-06 26.7 0.0 1.2e-05 25.4 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Glu_dehyd_C PF16912.5 CCF37137.1 - 0.0022 17.5 0.0 0.0037 16.8 0.0 1.3 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus Pyr_redox_2 PF07992.14 CCF37137.1 - 0.01 15.1 0.0 0.16 11.1 0.0 2.4 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 CCF37137.1 - 0.014 14.6 0.0 0.022 14.0 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain Thi4 PF01946.17 CCF37137.1 - 0.016 14.5 0.0 0.025 13.8 0.0 1.2 1 0 0 1 1 1 0 Thi4 family Trp_halogenase PF04820.14 CCF37137.1 - 0.016 14.0 0.0 0.93 8.3 0.0 2.1 2 0 0 2 2 2 0 Tryptophan halogenase Pyr_redox PF00070.27 CCF37137.1 - 0.042 14.4 0.0 0.098 13.2 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CCF37137.1 - 0.16 11.9 0.0 9.9 6.1 0.0 2.6 2 0 0 2 2 2 0 FAD-NAD(P)-binding CBM_48 PF02922.18 CCF37139.1 - 3.7e-15 56.1 0.2 9.5e-15 54.7 0.1 1.7 2 0 0 2 2 2 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) AMPK1_CBM PF16561.5 CCF37139.1 - 0.0039 17.4 0.1 0.0087 16.3 0.1 1.6 1 1 1 2 2 2 1 Glycogen recognition site of AMP-activated protein kinase AAA_2 PF07724.14 CCF37140.1 - 1e-31 110.4 0.0 2.4e-31 109.2 0.0 1.7 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA PF00004.29 CCF37140.1 - 8.8e-13 48.8 0.0 1.6e-12 48.0 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 CCF37140.1 - 1e-08 35.1 0.0 2.2e-08 34.0 0.0 1.5 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.14 CCF37140.1 - 1.8e-08 34.5 0.0 4e-08 33.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 CCF37140.1 - 3.7e-05 24.0 0.3 0.00093 19.5 0.3 2.6 1 1 0 1 1 1 1 AAA domain MCM PF00493.23 CCF37140.1 - 0.0003 20.0 0.0 0.00066 18.8 0.0 1.5 1 0 0 1 1 1 1 MCM P-loop domain AAA_7 PF12775.7 CCF37140.1 - 0.0017 17.9 0.0 0.0028 17.2 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_16 PF13191.6 CCF37140.1 - 0.0024 18.3 0.1 0.017 15.5 0.0 2.2 1 1 1 2 2 2 1 AAA ATPase domain AAA_14 PF13173.6 CCF37140.1 - 0.003 17.6 0.0 0.0055 16.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 CCF37140.1 - 0.017 14.9 0.0 0.031 14.0 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_18 PF13238.6 CCF37140.1 - 0.033 14.7 0.1 0.033 14.7 0.1 1.9 2 1 0 2 2 1 0 AAA domain TniB PF05621.11 CCF37140.1 - 0.059 12.8 0.1 0.43 10.0 0.0 2.1 2 0 0 2 2 2 0 Bacterial TniB protein ABC_tran PF00005.27 CCF37140.1 - 0.11 13.0 0.3 0.27 11.7 0.1 1.8 2 0 0 2 2 2 0 ABC transporter Rad17 PF03215.15 CCF37140.1 - 0.14 12.1 0.0 0.24 11.3 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_24 PF13479.6 CCF37140.1 - 0.14 11.9 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 CCF37140.1 - 0.17 11.3 0.0 1.2 8.5 0.0 2.1 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_29 PF13555.6 CCF37140.1 - 0.18 11.5 0.0 0.39 10.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain T2SSE PF00437.20 CCF37140.1 - 0.19 10.8 0.1 0.32 10.0 0.1 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_19 PF13245.6 CCF37140.1 - 0.2 12.0 0.8 0.45 10.9 0.1 1.9 2 1 0 2 2 2 0 AAA domain ATP-synt_ab PF00006.25 CCF37141.1 - 2.4e-55 187.5 0.1 7.8e-33 113.9 0.0 2.3 2 0 0 2 2 2 2 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 CCF37141.1 - 9.2e-24 83.8 0.4 2.4e-23 82.4 0.4 1.8 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain NB-ARC PF00931.22 CCF37141.1 - 0.017 14.3 0.4 0.092 11.9 0.1 2.0 2 0 0 2 2 2 0 NB-ARC domain AAA PF00004.29 CCF37141.1 - 0.018 15.5 0.4 6.4 7.2 0.0 3.5 4 0 0 4 4 4 0 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 CCF37141.1 - 0.032 14.1 0.1 0.032 14.1 0.1 1.9 3 0 0 3 3 3 0 RsgA GTPase RNA_helicase PF00910.22 CCF37141.1 - 0.042 14.2 0.0 0.19 12.1 0.0 2.0 2 0 0 2 2 2 0 RNA helicase ATPase PF06745.13 CCF37141.1 - 0.044 13.1 0.1 0.08 12.3 0.1 1.4 1 0 0 1 1 1 0 KaiC NACHT PF05729.12 CCF37141.1 - 0.056 13.4 0.0 0.15 12.0 0.0 1.7 1 0 0 1 1 1 0 NACHT domain AAA_19 PF13245.6 CCF37141.1 - 0.062 13.6 1.6 0.53 10.6 0.2 2.5 3 0 0 3 3 3 0 AAA domain T3SS_ATPase_C PF18269.1 CCF37141.1 - 0.063 13.1 0.7 0.35 10.8 0.7 2.1 1 1 0 1 1 1 0 T3SS EscN ATPase C-terminal domain AAA_16 PF13191.6 CCF37141.1 - 0.16 12.4 0.1 0.51 10.7 0.1 2.0 1 1 0 1 1 1 0 AAA ATPase domain Mus7 PF09462.10 CCF37142.1 - 6.4e-99 332.5 4.6 8.8e-99 332.0 4.6 1.2 1 0 0 1 1 1 1 Mus7/MMS22 family SKG6 PF08693.10 CCF37143.1 - 0.00044 19.6 4.9 0.0011 18.4 4.9 1.6 1 0 0 1 1 1 1 Transmembrane alpha-helix domain CBM-like PF14683.6 CCF37143.1 - 0.046 13.6 0.2 0.087 12.7 0.2 1.5 1 0 0 1 1 1 0 Polysaccharide lyase family 4, domain III MGC-24 PF05283.11 CCF37143.1 - 0.11 12.9 2.9 0.32 11.5 2.9 1.7 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Ank_5 PF13857.6 CCF37144.1 - 4.1e-08 33.3 0.0 7.6e-08 32.5 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 CCF37144.1 - 0.014 15.8 0.3 0.071 13.6 0.5 2.0 2 0 0 2 2 2 0 Ankyrin repeat CBP4 PF07960.11 CCF37144.1 - 3.5 7.5 9.6 6.7 6.6 3.5 2.2 2 0 0 2 2 2 0 CBP4 LigB PF02900.18 CCF37147.1 - 2.7e-05 23.4 0.0 0.0037 16.4 0.0 2.7 1 1 0 2 2 2 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase Cupin_2 PF07883.11 CCF37148.1 - 5.2e-06 26.1 0.0 7.6e-06 25.5 0.0 1.3 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 CCF37148.1 - 0.064 12.9 0.0 0.097 12.3 0.0 1.2 1 0 0 1 1 1 0 Cupin FAA_hydrolase PF01557.18 CCF37149.1 - 7.6e-25 87.9 0.0 8.4e-25 87.7 0.0 1.0 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Cys_box PF17869.1 CCF37150.1 - 0.091 12.9 0.2 0.21 11.7 0.2 1.6 1 0 0 1 1 1 0 Anosmin cysteine rich domain eIF2A PF08662.11 CCF37151.1 - 1.8e-78 262.9 0.0 7.7e-78 260.8 0.0 1.9 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A WD40 PF00400.32 CCF37151.1 - 0.0053 17.6 0.5 1.6 9.7 0.1 4.4 4 1 0 4 4 4 1 WD domain, G-beta repeat CIA30 PF08547.12 CCF37152.1 - 2.7e-46 157.5 0.0 3.5e-46 157.1 0.0 1.1 1 0 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) ANAPC5 PF12862.7 CCF37153.1 - 8.9e-33 112.2 5.3 1.6e-32 111.4 3.1 2.5 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 5 TPR_10 PF13374.6 CCF37153.1 - 0.043 13.7 1.2 6.8 6.7 0.2 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 CCF37153.1 - 0.34 11.5 15.5 1.3 9.6 1.0 5.7 5 1 0 5 5 5 0 Tetratricopeptide repeat DDE_1 PF03184.19 CCF37156.1 - 2e-32 112.2 0.0 3.9e-32 111.3 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 CCF37156.1 - 1.1e-11 44.6 0.0 3.1e-11 43.1 0.0 1.8 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 CCF37156.1 - 9.8e-09 34.8 0.0 1.8e-08 34.0 0.0 1.4 1 0 0 1 1 1 1 helix-turn-helix, Psq domain DDE_3 PF13358.6 CCF37156.1 - 0.0016 18.2 0.0 0.0051 16.6 0.0 1.8 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_23 PF13384.6 CCF37156.1 - 0.0089 15.8 0.0 0.036 13.9 0.0 2.0 1 0 0 1 1 1 1 Homeodomain-like domain CENP-B_N PF04218.13 CCF37156.1 - 0.049 13.3 0.0 0.093 12.4 0.0 1.4 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain KIND PF16474.5 CCF37157.1 - 1.8 8.4 5.0 3.1 7.6 0.4 2.7 2 1 1 3 3 3 0 Kinase non-catalytic C-lobe domain NAD_binding_8 PF13450.6 CCF37158.1 - 1.4e-14 54.0 0.1 2.6e-14 53.2 0.1 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 CCF37158.1 - 4.4e-07 29.5 0.6 2.2e-05 24.0 0.1 3.0 3 1 0 3 3 3 1 Flavin containing amine oxidoreductase DAO PF01266.24 CCF37158.1 - 0.00023 20.9 0.1 0.0017 18.0 0.1 2.1 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 CCF37158.1 - 0.019 15.0 0.1 0.93 9.5 0.0 3.1 2 1 1 3 3 3 0 FAD-NAD(P)-binding Methyltransf_25 PF13649.6 CCF37159.1 - 0.15 12.8 0.0 0.49 11.1 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase domain MFS_1 PF07690.16 CCF37160.1 - 3.3e-15 55.9 17.6 4.6e-15 55.4 17.6 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily EBV-NA1 PF02905.14 CCF37162.1 - 0.098 12.5 0.4 0.18 11.6 0.4 1.5 1 1 0 1 1 1 0 Epstein Barr virus nuclear antigen-1, DNA-binding domain Repressor_Mnt PF11423.8 CCF37162.1 - 0.19 11.5 0.0 0.31 10.8 0.0 1.3 1 0 0 1 1 1 0 Regulatory protein Mnt BTB PF00651.31 CCF37163.1 - 0.019 15.2 0.0 0.029 14.6 0.0 1.2 1 0 0 1 1 1 0 BTB/POZ domain EF-hand_4 PF12763.7 CCF37163.1 - 0.1 12.6 0.2 14 5.7 0.0 2.2 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand Cyclin PF08613.11 CCF37164.1 - 1.8e-30 106.5 1.1 2.5e-30 106.0 0.1 1.8 2 1 0 2 2 2 1 Cyclin Cyclin_N PF00134.23 CCF37164.1 - 0.0012 18.6 0.1 0.0019 18.0 0.1 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain zf-AN1 PF01428.16 CCF37166.1 - 4.5e-13 49.1 5.2 4.5e-13 49.1 5.2 1.5 1 1 0 1 1 1 1 AN1-like Zinc finger Transp_Tc5_C PF04236.15 CCF37166.1 - 0.97 9.8 7.4 0.44 10.9 5.4 1.5 2 0 0 2 2 2 0 Tc5 transposase C-terminal domain HhH-GPD PF00730.25 CCF37167.1 - 4.7e-18 65.6 0.0 8.7e-18 64.8 0.0 1.5 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 CCF37167.1 - 3e-09 36.3 0.0 6.8e-09 35.2 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix motif XFP_N PF09364.10 CCF37168.1 - 7.6e-166 551.4 0.0 9.9e-166 551.0 0.0 1.1 1 0 0 1 1 1 1 XFP N-terminal domain XFP_C PF09363.10 CCF37168.1 - 9.4e-81 270.1 0.0 1.3e-80 269.6 0.0 1.2 1 0 0 1 1 1 1 XFP C-terminal domain XFP PF03894.15 CCF37168.1 - 1.5e-80 269.1 0.0 2.4e-80 268.4 0.0 1.3 1 0 0 1 1 1 1 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase PALP PF00291.25 CCF37171.1 - 1.4e-38 133.0 0.1 1.6e-38 132.8 0.1 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Na_Ala_symp PF01235.17 CCF37171.1 - 0.043 13.1 0.0 0.061 12.6 0.0 1.1 1 0 0 1 1 1 0 Sodium:alanine symporter family LYTB PF02401.18 CCF37171.1 - 0.098 11.9 0.0 0.16 11.2 0.0 1.2 1 0 0 1 1 1 0 LytB protein OPT PF03169.15 CCF37172.1 - 6.4e-140 467.7 48.5 7.5e-140 467.5 48.5 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein UCR_UQCRX_QCR9 PF05365.12 CCF37172.1 - 9.9 6.2 8.8 44 4.1 0.0 4.4 4 0 0 4 4 4 0 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like F_bP_aldolase PF01116.20 CCF37173.1 - 5.7e-13 49.0 0.1 5.9e-13 48.9 0.1 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II CobS PF02654.15 CCF37173.1 - 0.01 16.1 0.0 0.011 15.9 0.0 1.1 1 0 0 1 1 1 0 Cobalamin-5-phosphate synthase ABC2_membrane PF01061.24 CCF37174.1 - 1.7e-48 164.8 34.9 5.2e-43 146.9 20.6 2.6 3 0 0 3 3 3 2 ABC-2 type transporter ABC_tran PF00005.27 CCF37174.1 - 2.8e-35 121.8 0.2 4.3e-16 59.7 0.0 3.2 3 0 0 3 3 3 2 ABC transporter PDR_CDR PF06422.12 CCF37174.1 - 1.6e-28 98.4 0.0 4.9e-28 96.9 0.0 1.9 1 0 0 1 1 1 1 CDR ABC transporter ABC_trans_N PF14510.6 CCF37174.1 - 4.2e-14 52.9 3.0 5e-14 52.7 0.7 2.4 3 0 0 3 3 1 1 ABC-transporter N-terminal ABC2_membrane_3 PF12698.7 CCF37174.1 - 3.8e-06 26.2 7.3 3.8e-06 26.2 7.3 1.7 2 0 0 2 2 2 1 ABC-2 family transporter protein RsgA_GTPase PF03193.16 CCF37174.1 - 7.1e-06 26.0 0.0 2.9e-05 24.0 0.0 1.9 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 CCF37174.1 - 9.2e-06 26.1 0.7 0.0029 18.0 0.1 3.1 3 1 0 3 3 2 1 AAA ATPase domain AAA_21 PF13304.6 CCF37174.1 - 9.4e-06 25.6 0.0 0.034 14.0 0.0 2.6 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CCF37174.1 - 2.5e-05 24.0 0.0 0.018 14.7 0.1 3.0 3 0 0 3 3 2 1 P-loop containing region of AAA domain AAA_25 PF13481.6 CCF37174.1 - 3.2e-05 23.6 0.2 0.0097 15.5 0.1 2.5 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 CCF37174.1 - 0.00012 22.4 0.2 0.033 14.5 0.1 2.9 2 1 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 CCF37174.1 - 0.0002 21.4 0.1 0.18 11.9 0.1 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_18 PF13238.6 CCF37174.1 - 0.00021 21.9 0.1 0.003 18.1 0.0 2.7 3 0 0 3 3 2 1 AAA domain T2SSE PF00437.20 CCF37174.1 - 0.00078 18.6 0.0 0.38 9.8 0.0 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_17 PF13207.6 CCF37174.1 - 0.0012 19.3 1.3 0.37 11.2 0.0 2.9 3 0 0 3 3 2 1 AAA domain NACHT PF05729.12 CCF37174.1 - 0.0013 18.7 0.0 0.096 12.6 0.0 2.7 2 0 0 2 2 2 1 NACHT domain AAA_30 PF13604.6 CCF37174.1 - 0.0017 18.1 0.0 0.42 10.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.6 CCF37174.1 - 0.0027 18.2 4.7 0.018 15.6 0.0 3.2 4 0 0 4 4 4 1 AAA domain cobW PF02492.19 CCF37174.1 - 0.0042 16.7 0.1 0.11 12.1 0.0 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_28 PF13521.6 CCF37174.1 - 0.0042 17.3 0.2 0.0042 17.3 0.2 2.7 3 0 0 3 3 2 1 AAA domain AAA_33 PF13671.6 CCF37174.1 - 0.018 15.2 4.6 0.12 12.5 0.0 3.1 4 0 0 4 4 2 0 AAA domain FtsK_SpoIIIE PF01580.18 CCF37174.1 - 0.023 14.1 0.0 8.4 5.7 0.0 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family RNA_helicase PF00910.22 CCF37174.1 - 0.032 14.6 0.0 3.7 8.0 0.0 2.7 2 0 0 2 2 2 0 RNA helicase dNK PF01712.19 CCF37174.1 - 0.057 13.3 0.0 0.21 11.4 0.0 1.9 2 0 0 2 2 2 0 Deoxynucleoside kinase TsaE PF02367.17 CCF37174.1 - 0.057 13.4 0.1 0.24 11.4 0.2 1.9 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA PF00004.29 CCF37174.1 - 0.36 11.3 5.3 1.4 9.4 0.1 3.3 4 0 0 4 4 2 0 ATPase family associated with various cellular activities (AAA) GET2 PF08690.10 CCF37174.1 - 1.1 8.9 10.5 0.24 11.1 5.1 2.3 2 0 0 2 2 2 0 GET complex subunit GET2 Aminotran_3 PF00202.21 CCF37175.1 - 2.2e-23 82.6 1.7 1.4e-12 47.0 0.3 2.0 2 0 0 2 2 2 2 Aminotransferase class-III DUF5560 PF17715.1 CCF37177.1 - 0.00039 19.9 0.5 0.00039 19.9 0.5 2.1 3 0 0 3 3 3 1 Family of unknown function (DUF5560) BTB PF00651.31 CCF37178.1 - 0.0083 16.3 0.0 0.014 15.6 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain Peptidase_A4 PF01828.17 CCF37179.1 - 2.3e-55 187.3 1.4 2.7e-55 187.1 1.4 1.1 1 0 0 1 1 1 1 Peptidase A4 family TPP_enzyme_N PF02776.18 CCF37180.1 - 3.7e-54 182.9 0.1 1.8e-51 174.1 0.0 2.4 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 CCF37180.1 - 8.4e-51 171.8 0.2 1.5e-49 167.7 0.1 2.5 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 CCF37180.1 - 5.7e-40 136.2 0.4 1.6e-39 134.8 0.4 1.8 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain ABC2_membrane PF01061.24 CCF37182.1 - 1.1e-78 263.5 63.8 1.2e-40 139.2 27.7 3.8 4 0 0 4 4 4 2 ABC-2 type transporter ABC_tran PF00005.27 CCF37182.1 - 1.8e-37 128.9 0.1 3.6e-17 63.2 0.0 3.0 3 0 0 3 3 3 2 ABC transporter PDR_CDR PF06422.12 CCF37182.1 - 8.6e-37 124.9 6.0 2.8e-30 104.1 0.2 3.2 3 0 0 3 3 2 2 CDR ABC transporter ABC_trans_N PF14510.6 CCF37182.1 - 7.7e-19 68.1 0.1 2.1e-18 66.7 0.1 1.8 1 0 0 1 1 1 1 ABC-transporter N-terminal AAA_25 PF13481.6 CCF37182.1 - 2.3e-07 30.6 0.1 5.6e-05 22.8 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 CCF37182.1 - 6.3e-07 29.9 0.1 0.00023 21.6 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain AAA_33 PF13671.6 CCF37182.1 - 3e-06 27.4 0.2 0.0029 17.8 0.0 3.0 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 CCF37182.1 - 2.5e-05 24.2 0.1 0.0045 16.9 0.0 2.6 2 0 0 2 2 2 1 RsgA GTPase AAA_18 PF13238.6 CCF37182.1 - 0.00031 21.3 0.1 0.0046 17.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 CCF37182.1 - 0.0012 18.5 2.3 0.052 13.3 0.1 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_22 PF13401.6 CCF37182.1 - 0.0029 17.9 0.7 2 8.7 0.1 3.1 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 CCF37182.1 - 0.0037 17.0 0.1 0.89 9.2 0.1 2.9 3 0 0 3 3 3 1 AAA domain cobW PF02492.19 CCF37182.1 - 0.0056 16.3 1.6 0.053 13.1 0.1 2.2 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain SMC_N PF02463.19 CCF37182.1 - 0.008 15.6 0.0 1.6 8.1 0.0 3.2 2 2 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 CCF37182.1 - 0.013 15.3 0.0 1.4 8.7 0.0 2.6 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system MMR_HSR1 PF01926.23 CCF37182.1 - 0.026 14.6 0.1 7.8 6.6 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase NACHT PF05729.12 CCF37182.1 - 0.028 14.3 0.8 2.3 8.1 0.2 2.5 2 0 0 2 2 2 0 NACHT domain dNK PF01712.19 CCF37182.1 - 0.043 13.7 0.0 1.8 8.4 0.0 2.3 2 0 0 2 2 2 0 Deoxynucleoside kinase Ploopntkinase3 PF18751.1 CCF37182.1 - 0.062 13.2 0.2 0.62 10.0 0.0 2.3 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 AAA_17 PF13207.6 CCF37182.1 - 0.074 13.5 0.0 1.5 9.2 0.0 2.8 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 CCF37182.1 - 0.094 13.1 0.1 27 5.2 0.0 2.7 2 0 0 2 2 2 0 RNA helicase Zeta_toxin PF06414.12 CCF37182.1 - 0.13 11.5 0.1 6.1 6.1 0.0 2.6 2 0 0 2 2 2 0 Zeta toxin GMC_oxred_N PF00732.19 CCF37183.1 - 3.3e-50 171.2 0.1 1.4e-49 169.1 0.0 1.8 2 0 0 2 2 2 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCF37183.1 - 1.1e-31 110.3 0.1 1.7e-31 109.7 0.1 1.3 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.12 CCF37183.1 - 1e-05 24.8 0.1 1.6e-05 24.1 0.1 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein GIDA PF01134.22 CCF37183.1 - 7.3e-05 22.0 0.0 0.06 12.4 0.0 2.1 2 0 0 2 2 2 2 Glucose inhibited division protein A Pyr_redox_2 PF07992.14 CCF37183.1 - 0.018 14.3 0.1 0.034 13.4 0.1 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCF37183.1 - 0.063 13.5 0.1 0.15 12.3 0.1 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Glyco_hydro_7 PF00840.20 CCF37184.1 - 5.4e-143 476.8 11.6 6.8e-143 476.5 11.6 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 7 HET PF06985.11 CCF37185.1 - 8.5e-33 113.8 0.2 1.3e-32 113.1 0.2 1.3 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) FAINT PF04385.15 CCF37185.1 - 0.05 13.7 0.0 0.11 12.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function, DUF529 DUF3328 PF11807.8 CCF37186.1 - 1.4e-25 90.4 0.1 1.7e-25 90.1 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Peptidase_S10 PF00450.22 CCF37187.1 - 1.1e-71 242.5 0.1 1.4e-71 242.1 0.1 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Lipase_3 PF01764.25 CCF37187.1 - 0.015 15.1 0.0 0.051 13.4 0.0 1.7 1 1 1 2 2 2 0 Lipase (class 3) AA_permease PF00324.21 CCF37189.1 - 2e-63 214.7 29.2 2.5e-63 214.4 29.2 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CCF37189.1 - 8.9e-17 61.0 34.0 1.8e-16 60.0 34.0 1.5 1 1 0 1 1 1 1 Amino acid permease SLC12 PF03522.15 CCF37189.1 - 1.8e-14 53.6 0.1 2.4e-09 36.7 0.0 2.2 2 0 0 2 2 2 2 Solute carrier family 12 FXR_C1 PF16096.5 CCF37189.1 - 0.086 13.1 0.1 0.16 12.2 0.1 1.3 1 0 0 1 1 1 0 Fragile X-related 1 protein C-terminal region 2 DUF4231 PF14015.6 CCF37189.1 - 0.51 10.8 4.5 30 5.1 0.1 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) Asp PF00026.23 CCF37190.1 - 1.3e-51 175.9 0.0 1.8e-51 175.4 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCF37190.1 - 1.9e-09 38.0 0.4 1.9e-09 38.0 0.4 2.5 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 CCF37190.1 - 0.061 14.0 0.6 12 6.6 0.0 3.2 3 0 0 3 3 3 0 Aspartyl protease gag-asp_proteas PF13975.6 CCF37190.1 - 0.12 12.9 0.2 20 5.8 0.0 3.3 2 1 0 2 2 2 0 gag-polyprotein putative aspartyl protease SOG2 PF10428.9 CCF37190.1 - 0.5 9.5 5.6 0.85 8.8 5.6 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein 2OG-FeII_Oxy_2 PF13532.6 CCF37191.1 - 2e-16 60.7 0.1 4.9e-16 59.5 0.0 1.7 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily DUF4334 PF14232.6 CCF37193.1 - 2.4e-24 85.1 0.4 5.8e-24 83.8 0.2 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4334) GXWXG PF14231.6 CCF37193.1 - 2.6e-19 69.0 0.9 4e-19 68.4 0.9 1.3 1 0 0 1 1 1 1 GXWXG protein DUF3328 PF11807.8 CCF37194.1 - 6e-11 42.5 0.4 7.8e-11 42.2 0.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) MM_CoA_mutase PF01642.22 CCF37194.1 - 0.25 9.9 0.0 0.3 9.6 0.0 1.1 1 0 0 1 1 1 0 Methylmalonyl-CoA mutase GPI2 PF06432.11 CCF37195.1 - 2.4e-43 148.6 0.1 2.9e-43 148.3 0.1 1.1 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase DFP PF04127.15 CCF37196.1 - 0.04 13.8 0.0 0.055 13.3 0.0 1.1 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein Glyco_hydro_61 PF03443.14 CCF37197.1 - 1.1e-55 188.8 0.1 1.4e-55 188.4 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 CAP_N PF01213.19 CCF37197.1 - 5.9 6.3 5.9 8.2 5.8 5.9 1.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal COesterase PF00135.28 CCF37198.1 - 3.3e-82 277.0 3.2 7.5e-82 275.8 3.2 1.5 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CCF37198.1 - 9e-06 25.7 0.1 4.5e-05 23.4 0.0 2.2 2 0 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CCF37198.1 - 0.0026 17.3 0.1 0.0026 17.3 0.1 2.1 2 1 0 2 2 2 1 Prolyl oligopeptidase family ABC1 PF03109.16 CCF37199.1 - 2.9e-22 79.1 0.0 5.6e-13 49.1 0.0 2.8 2 1 1 3 3 3 2 ABC1 family APH PF01636.23 CCF37199.1 - 0.0042 17.0 0.2 0.03 14.3 0.1 2.5 2 1 0 2 2 2 1 Phosphotransferase enzyme family POTRA_TamA_1 PF17243.2 CCF37199.1 - 0.019 15.0 0.0 2.2 8.5 0.0 2.6 2 0 0 2 2 2 0 POTRA domain TamA domain 1 SCP2 PF02036.17 CCF37202.1 - 3.2e-26 91.8 0.4 3.7e-26 91.6 0.4 1.1 1 0 0 1 1 1 1 SCP-2 sterol transfer family Alkyl_sulf_C PF14864.6 CCF37202.1 - 3.7e-05 24.0 0.2 5.2e-05 23.5 0.1 1.3 1 1 0 1 1 1 1 Alkyl sulfatase C-terminal SCP2_2 PF13530.6 CCF37202.1 - 0.028 14.8 0.0 0.035 14.5 0.0 1.2 1 0 0 1 1 1 0 Sterol carrier protein domain Ran_BP1 PF00638.18 CCF37203.1 - 2.1e-10 40.9 0.0 1e-09 38.7 0.0 2.0 1 1 0 1 1 1 1 RanBP1 domain Nucleoporin_FG PF13634.6 CCF37203.1 - 0.00034 21.4 41.8 0.0025 18.6 22.6 10.2 2 1 7 9 9 9 4 Nucleoporin FG repeat region DUF92 PF01940.16 CCF37204.1 - 2.5e-90 302.0 1.4 3.2e-90 301.7 1.4 1.1 1 0 0 1 1 1 1 Integral membrane protein DUF92 Mito_carr PF00153.27 CCF37205.1 - 8.9e-41 137.7 4.0 3e-15 55.9 0.1 3.7 3 1 0 3 3 3 3 Mitochondrial carrier protein Ribosomal_L22e PF01776.17 CCF37206.1 - 3.9e-46 155.9 1.7 4.8e-46 155.6 1.7 1.0 1 0 0 1 1 1 1 Ribosomal L22e protein family DUF3568 PF12092.8 CCF37206.1 - 0.11 12.6 0.9 0.19 11.8 0.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3568) DPBB_1 PF03330.18 CCF37207.1 - 6.7e-08 32.7 1.1 3.5e-07 30.4 0.1 2.6 2 1 0 2 2 2 1 Lytic transglycolase Barwin PF00967.17 CCF37207.1 - 7.5e-06 25.8 0.1 1.4e-05 24.9 0.1 1.4 1 0 0 1 1 1 1 Barwin family Pollen_allerg_1 PF01357.21 CCF37207.1 - 0.00078 19.4 0.2 0.0018 18.3 0.2 1.6 1 0 0 1 1 1 1 Pollen allergen BNR PF02012.20 CCF37207.1 - 0.061 13.3 0.2 0.19 11.9 0.2 1.9 1 0 0 1 1 1 0 BNR/Asp-box repeat EF-hand_1 PF00036.32 CCF37209.1 - 3.2e-11 41.9 7.5 3.8e-05 22.9 0.5 3.9 3 0 0 3 3 3 2 EF hand ZZ PF00569.17 CCF37209.1 - 4e-10 39.3 7.3 7.1e-10 38.5 7.3 1.3 1 0 0 1 1 1 1 Zinc finger, ZZ type EF-hand_6 PF13405.6 CCF37209.1 - 1.3e-07 31.0 6.2 0.00071 19.3 0.4 4.2 4 0 0 4 4 4 2 EF-hand domain EF-hand_7 PF13499.6 CCF37209.1 - 0.00019 21.8 16.5 0.0037 17.7 0.5 4.0 3 1 0 4 4 4 2 EF-hand domain pair EF-hand_8 PF13833.6 CCF37209.1 - 0.00023 21.0 2.8 0.7 9.8 0.0 3.6 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_4 PF12763.7 CCF37209.1 - 0.025 14.5 0.8 0.14 12.1 0.0 2.6 3 1 0 3 3 3 0 Cytoskeletal-regulatory complex EF hand C1_2 PF03107.16 CCF37209.1 - 0.09 13.1 9.4 0.17 12.2 9.4 1.4 1 0 0 1 1 1 0 C1 domain EF-hand_5 PF13202.6 CCF37209.1 - 1.3 8.7 11.3 1.3 8.6 0.7 3.7 3 0 0 3 3 3 0 EF hand DUF2737 PF10930.8 CCF37210.1 - 0.16 11.6 0.0 0.22 11.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2737) adh_short PF00106.25 CCF37211.1 - 3.8e-37 127.7 0.2 6.7e-37 126.9 0.2 1.4 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF37211.1 - 1.4e-32 113.1 0.3 3.7e-30 105.2 0.3 2.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF37211.1 - 2.2e-09 37.5 2.0 2.5e-08 34.0 2.0 2.2 1 1 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 CCF37211.1 - 0.076 12.9 0.3 0.12 12.2 0.3 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Epimerase PF01370.21 CCF37211.1 - 0.17 11.3 0.1 0.23 10.9 0.1 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family N1221 PF07923.13 CCF37211.1 - 0.21 10.7 0.0 0.27 10.4 0.0 1.1 1 0 0 1 1 1 0 N1221-like protein FAD_binding_3 PF01494.19 CCF37212.1 - 9.1e-59 199.4 0.3 1.5e-31 110.0 0.1 2.7 2 1 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 CCF37212.1 - 9.8e-07 28.9 0.0 2.7e-06 27.5 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CCF37212.1 - 1.2e-06 28.3 0.8 5.2e-06 26.3 0.1 2.1 2 1 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 CCF37212.1 - 0.00021 20.6 0.0 0.00033 20.0 0.0 1.2 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.14 CCF37212.1 - 0.0006 19.1 0.1 0.0031 16.8 0.1 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCF37212.1 - 0.0036 16.6 0.0 0.0057 15.9 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CCF37212.1 - 0.016 13.9 0.0 0.022 13.5 0.0 1.1 1 0 0 1 1 1 0 HI0933-like protein Glu_dehyd_C PF16912.5 CCF37212.1 - 0.018 14.6 0.0 0.036 13.5 0.0 1.5 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus ApbA PF02558.16 CCF37212.1 - 0.082 12.5 0.0 0.16 11.6 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Pyr_redox PF00070.27 CCF37212.1 - 0.12 13.0 0.0 0.25 11.9 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 CCF37212.1 - 0.18 11.6 0.7 1.2 9.0 0.0 2.5 3 0 0 3 3 3 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain LysM PF01476.20 CCF37214.1 - 0.00021 21.3 0.0 0.00027 21.0 0.0 1.1 1 0 0 1 1 1 1 LysM domain Aldo_ket_red PF00248.21 CCF37215.1 - 1.9e-69 234.1 0.0 2.2e-69 233.9 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family IDEAL PF08858.10 CCF37215.1 - 0.055 13.2 0.1 0.14 11.9 0.1 1.6 1 0 0 1 1 1 0 IDEAL domain CedA PF10729.9 CCF37215.1 - 0.11 12.3 0.0 0.25 11.2 0.0 1.6 1 0 0 1 1 1 0 Cell division activator CedA Amidohydro_3 PF07969.11 CCF37217.1 - 3.7e-67 227.8 0.1 4.5e-67 227.5 0.1 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_1 PF01979.20 CCF37217.1 - 1.8e-05 24.2 0.0 0.0004 19.8 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase family WSC PF01822.19 CCF37218.1 - 5.1e-11 42.6 8.8 5.1e-11 42.6 8.8 2.0 2 0 0 2 2 2 1 WSC domain Podoplanin PF05808.11 CCF37218.1 - 0.00026 21.1 10.8 0.00043 20.4 10.8 1.3 1 0 0 1 1 1 1 Podoplanin SKG6 PF08693.10 CCF37218.1 - 0.00082 18.7 0.4 0.0019 17.6 0.4 1.6 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Gram_pos_anchor PF00746.21 CCF37218.1 - 0.0027 17.6 0.3 0.0065 16.4 0.3 1.7 1 0 0 1 1 1 1 LPXTG cell wall anchor motif TMEM154 PF15102.6 CCF37218.1 - 0.0066 16.3 0.5 0.0066 16.3 0.5 2.2 1 1 1 2 2 2 1 TMEM154 protein family DUF2207 PF09972.9 CCF37218.1 - 0.014 14.2 0.0 0.019 13.7 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF4366 PF14283.6 CCF37218.1 - 0.021 14.9 0.1 0.041 13.9 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) PTP_tm PF18861.1 CCF37218.1 - 0.076 13.0 0.2 0.12 12.3 0.2 1.3 1 0 0 1 1 1 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J DUF1180 PF06679.12 CCF37218.1 - 0.12 12.7 5.1 0.23 11.9 5.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) EphA2_TM PF14575.6 CCF37218.1 - 0.17 12.8 0.0 0.39 11.6 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Adeno_E3_CR2 PF02439.15 CCF37218.1 - 0.18 11.6 0.0 0.36 10.6 0.0 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Phage_holin_2_4 PF16082.5 CCF37218.1 - 0.19 11.5 0.0 0.19 11.5 0.0 1.7 2 0 0 2 2 1 0 Bacteriophage holin family, superfamily II-like TALPID3 PF15324.6 CCF37218.1 - 2.1 5.9 11.9 3.6 5.1 11.9 1.3 1 0 0 1 1 1 0 Hedgehog signalling target NAD_binding_4 PF07993.12 CCF37219.1 - 2.6e-38 131.7 0.0 4.6e-38 130.9 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.21 CCF37219.1 - 3.1e-17 62.9 0.0 4.5e-17 62.3 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CCF37219.1 - 3e-11 42.9 0.0 4e-11 42.4 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family PP-binding PF00550.25 CCF37219.1 - 1.5e-09 38.1 0.4 2.7e-09 37.2 0.4 1.5 1 0 0 1 1 1 1 Phosphopantetheine attachment site RmlD_sub_bind PF04321.17 CCF37219.1 - 9e-05 21.7 0.1 0.071 12.2 0.0 2.2 2 0 0 2 2 2 2 RmlD substrate binding domain NAD_binding_10 PF13460.6 CCF37219.1 - 0.00039 20.4 0.0 0.00066 19.6 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 CCF37219.1 - 0.00065 19.2 0.0 0.00093 18.7 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase ketoacyl-synt PF00109.26 CCF37220.1 - 3.5e-57 193.9 0.0 4e-57 193.7 0.0 1.0 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Thiolase_N PF00108.23 CCF37220.1 - 1.5e-06 27.8 0.0 2.2e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain ACP_syn_III PF08545.10 CCF37220.1 - 0.00067 19.5 0.1 0.0012 18.7 0.1 1.4 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III p450 PF00067.22 CCF37221.1 - 1.6e-30 106.3 0.0 1.8e-30 106.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF4448 PF14610.6 CCF37221.1 - 0.075 12.8 0.0 0.1 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) PP2C PF00481.21 CCF37224.1 - 1e-30 107.2 0.0 2e-30 106.3 0.0 1.3 1 1 0 1 1 1 1 Protein phosphatase 2C OST3_OST6 PF04756.13 CCF37227.1 - 6e-111 370.5 0.0 7.1e-111 370.2 0.0 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family HXXEE PF13787.6 CCF37227.1 - 0.087 13.6 0.3 0.087 13.6 0.3 1.9 2 0 0 2 2 2 0 Protein of unknown function with HXXEE motif MerC PF03203.14 CCF37227.1 - 0.44 11.0 5.8 2.3 8.7 0.2 2.6 2 0 0 2 2 2 0 MerC mercury resistance protein QCR10 PF09796.9 CCF37227.1 - 0.63 10.1 2.8 11 6.2 0.0 3.1 2 1 1 3 3 3 0 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) DUF2721 PF11026.8 CCF37227.1 - 0.84 9.5 4.6 2.8 7.8 0.2 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2721) WD40 PF00400.32 CCF37228.1 - 1e-45 152.8 21.4 1.1e-08 35.5 0.2 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF37228.1 - 6.7e-09 35.9 0.7 0.098 13.0 0.0 4.5 2 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CCF37228.1 - 1.4e-05 23.9 6.5 0.078 11.6 0.1 4.3 1 1 3 4 4 4 3 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 CCF37228.1 - 0.0024 16.9 0.1 8.3 5.3 0.0 4.0 2 2 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 CCF37228.1 - 0.0077 15.6 0.0 0.5 9.6 0.0 2.3 2 1 0 2 2 2 1 WD40-like domain PD40 PF07676.12 CCF37228.1 - 0.018 15.0 0.6 22 5.1 0.0 4.4 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat TAF8_C PF10406.9 CCF37229.1 - 4e-17 62.5 0.2 4e-17 62.5 0.2 2.0 2 0 0 2 2 2 1 Transcription factor TFIID complex subunit 8 C-term Bromo_TP PF07524.13 CCF37229.1 - 1.6e-11 44.0 0.0 2.3e-11 43.5 0.0 1.3 1 0 0 1 1 1 1 Bromodomain associated DUF4953 PF16313.5 CCF37229.1 - 0.019 14.2 0.7 0.028 13.6 0.7 1.2 1 0 0 1 1 1 0 Met-zincin PilP PF04351.13 CCF37229.1 - 0.44 10.5 2.1 1.7 8.6 2.1 1.9 1 1 0 1 1 1 0 Pilus assembly protein, PilP LRR_8 PF13855.6 CCF37230.1 - 2.3e-12 46.5 0.2 1.3e-07 31.2 0.1 3.8 2 2 1 4 4 4 3 Leucine rich repeat LRR_4 PF12799.7 CCF37230.1 - 1.1e-09 38.4 1.2 0.049 14.1 0.0 4.8 3 1 3 6 6 6 5 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 CCF37230.1 - 0.027 14.0 0.0 1.7 8.1 0.1 2.6 1 1 2 3 3 3 0 Leucine-rich repeat LRR_1 PF00560.33 CCF37230.1 - 0.046 14.3 4.3 6.5 7.7 0.1 4.6 3 2 0 3 3 3 0 Leucine Rich Repeat RsmF_methylt_CI PF17126.5 CCF37230.1 - 0.1 12.6 0.0 12 6.0 0.0 3.0 3 0 0 3 3 3 0 RsmF rRNA methyltransferase first C-terminal domain bZIP_1 PF00170.21 CCF37231.1 - 1.4e-09 37.9 7.1 2.4e-09 37.1 7.1 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_Maf PF03131.17 CCF37231.1 - 0.001 19.6 1.2 0.001 19.6 1.2 2.2 2 0 0 2 2 2 1 bZIP Maf transcription factor bZIP_2 PF07716.15 CCF37231.1 - 0.0097 16.0 8.3 0.0097 16.0 8.3 2.1 2 0 0 2 2 2 1 Basic region leucine zipper p450 PF00067.22 CCF37232.1 - 9.1e-63 212.6 0.0 1.1e-62 212.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Rhodanese PF00581.20 CCF37233.1 - 0.0081 16.7 0.0 0.012 16.1 0.0 1.2 1 0 0 1 1 1 1 Rhodanese-like domain Ilar_coat PF01787.16 CCF37234.1 - 0.13 12.1 3.6 0.15 11.9 3.6 1.2 1 0 0 1 1 1 0 Ilarvirus coat protein DUF3752 PF12572.8 CCF37235.1 - 3.8e-49 167.1 11.8 3.8e-49 167.1 11.8 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF3752) Vps8 PF12816.7 CCF37236.1 - 4.2e-39 134.1 1.3 6.5e-39 133.5 1.3 1.3 1 0 0 1 1 1 1 Golgi CORVET complex core vacuolar protein 8 TauD PF02668.16 CCF37237.1 - 4.6e-35 121.7 0.5 7.3e-34 117.8 0.5 2.0 1 1 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Aldo_ket_red PF00248.21 CCF37238.1 - 9.6e-46 156.3 0.0 1.2e-45 156.0 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Voltage_CLC PF00654.20 CCF37240.1 - 2.6e-88 296.7 27.3 4.5e-88 295.9 27.3 1.3 1 0 0 1 1 1 1 Voltage gated chloride channel CBS PF00571.28 CCF37240.1 - 0.0027 18.1 0.0 0.025 15.0 0.0 2.3 2 0 0 2 2 2 1 CBS domain LacI PF00356.21 CCF37240.1 - 0.36 10.7 1.8 0.92 9.4 1.8 1.6 1 0 0 1 1 1 0 Bacterial regulatory proteins, lacI family UPF0154 PF03672.13 CCF37240.1 - 2.7 8.1 5.0 8.2 6.5 1.0 2.9 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0154) TIR_2 PF13676.6 CCF37241.1 - 0.16 12.5 0.0 0.62 10.7 0.0 1.9 2 0 0 2 2 2 0 TIR domain Sel1 PF08238.12 CCF37243.1 - 1.9e-11 44.2 0.6 0.0063 17.2 0.1 3.9 4 0 0 4 4 4 3 Sel1 repeat TraC PF07820.12 CCF37243.1 - 1.7 9.0 4.4 0.37 11.1 0.2 2.1 2 0 0 2 2 2 0 TraC-like protein Dopey_N PF04118.14 CCF37244.1 - 1.2e-119 399.0 0.0 2e-119 398.3 0.0 1.3 1 0 0 1 1 1 1 Dopey, N-terminal Mon1 PF03164.14 CCF37245.1 - 1.6e-151 505.0 0.0 1.9e-151 504.8 0.0 1.0 1 0 0 1 1 1 1 Trafficking protein Mon1 IFRD_C PF04836.12 CCF37245.1 - 0.15 12.7 0.1 0.33 11.6 0.1 1.5 1 0 0 1 1 1 0 Interferon-related protein conserved region Mid2 PF04478.12 CCF37246.1 - 0.022 14.6 0.0 0.038 13.8 0.0 1.4 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor Sporozoite_P67 PF05642.11 CCF37246.1 - 1.6 6.7 8.7 2 6.4 8.7 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF4148 PF13663.6 CCF37248.1 - 0.13 12.5 0.1 1.8 8.8 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4148) AAA PF00004.29 CCF37249.1 - 2.1e-09 37.9 0.5 4.2e-08 33.7 0.4 2.8 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 CCF37249.1 - 5e-06 26.6 0.0 0.0014 18.5 0.0 3.1 3 0 0 3 3 3 1 Rad17 P-loop domain AAA_16 PF13191.6 CCF37249.1 - 3.2e-05 24.4 0.0 0.0001 22.7 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 CCF37249.1 - 0.0072 16.6 0.1 0.028 14.7 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CCF37249.1 - 0.019 15.5 0.0 0.11 13.1 0.0 2.1 1 1 0 1 1 1 0 AAA domain AAA_14 PF13173.6 CCF37249.1 - 0.035 14.1 0.0 0.092 12.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.13 CCF37249.1 - 0.057 12.6 0.0 0.089 12.0 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain TsaE PF02367.17 CCF37249.1 - 0.068 13.2 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RuvB_N PF05496.12 CCF37249.1 - 0.12 12.1 0.0 0.35 10.6 0.0 1.7 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 CCF37249.1 - 0.13 12.6 0.0 0.4 11.1 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_7 PF12775.7 CCF37249.1 - 0.15 11.6 0.0 0.26 10.8 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region NTPase_1 PF03266.15 CCF37249.1 - 0.2 11.6 0.0 4.3 7.2 0.0 2.3 2 0 0 2 2 2 0 NTPase AT_hook PF02178.19 CCF37249.1 - 0.65 10.1 7.5 3.5 7.8 7.5 2.4 1 0 0 1 1 1 0 AT hook motif Utp8 PF10395.9 CCF37250.1 - 0.00018 20.2 0.0 0.0045 15.6 0.0 2.5 2 1 0 2 2 2 1 Utp8 family BCOR PF15808.5 CCF37251.1 - 2.7 8.1 10.1 0.67 10.1 4.5 2.1 1 1 1 2 2 2 0 BCL-6 co-repressor, non-ankyrin-repeat region DUF1741 PF08427.10 CCF37252.1 - 3.2e-85 285.5 0.0 6.7e-85 284.5 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1741) FMN_red PF03358.15 CCF37253.1 - 1.5e-23 83.2 0.0 2e-23 82.8 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 CCF37253.1 - 2.7e-05 24.0 0.0 3.5e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin-like fold preATP-grasp_3 PF18301.1 CCF37253.1 - 0.11 12.8 0.0 0.25 11.7 0.0 1.6 1 0 0 1 1 1 0 pre ATP-grasp 3 domain Asp PF00026.23 CCF37254.1 - 3.4e-26 92.4 0.0 9.6e-26 90.9 0.0 1.7 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCF37254.1 - 5.1e-06 26.9 0.1 2.1e-05 24.9 0.1 1.9 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Glyco_hydro_18 PF00704.28 CCF37255.1 - 6.7e-05 22.8 0.1 7.2e-05 22.7 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Mito_carr PF00153.27 CCF37256.1 - 3.1e-53 177.7 3.2 8.9e-18 64.0 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Phage_Coat_B PF05356.11 CCF37256.1 - 0.046 13.6 0.7 2.8 7.9 0.0 2.9 3 0 0 3 3 3 0 Phage Coat protein B PT-VENN PF04829.13 CCF37256.1 - 7.7 6.7 7.3 11 6.2 0.1 3.3 4 0 0 4 4 4 0 Pre-toxin domain with VENN motif PNP_UDP_1 PF01048.20 CCF37257.1 - 7.1e-11 41.8 0.2 1.3e-09 37.7 0.2 2.3 1 1 0 1 1 1 1 Phosphorylase superfamily DDE_1 PF03184.19 CCF37258.1 - 6.8e-19 68.2 0.0 2.1e-18 66.6 0.0 1.8 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_psq PF05225.16 CCF37258.1 - 2.2e-11 43.3 0.1 4.4e-11 42.3 0.1 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.16 CCF37258.1 - 6.9e-11 42.0 0.2 2.7e-10 40.1 0.0 2.1 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_23 PF13384.6 CCF37258.1 - 0.00027 20.6 0.1 0.00092 18.9 0.1 2.0 1 0 0 1 1 1 1 Homeodomain-like domain HTH_7 PF02796.15 CCF37258.1 - 0.0017 18.4 0.1 0.0035 17.4 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_30 PF13556.6 CCF37258.1 - 0.0053 16.5 0.1 0.012 15.4 0.1 1.6 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain HTH_28 PF13518.6 CCF37258.1 - 0.011 15.9 0.1 0.034 14.3 0.1 2.0 1 1 0 1 1 1 0 Helix-turn-helix domain HTH_Tnp_1 PF01527.20 CCF37258.1 - 0.038 14.3 0.3 0.088 13.1 0.1 1.7 1 1 0 1 1 1 0 Transposase HTH_1 PF00126.27 CCF37258.1 - 0.074 13.0 0.8 0.18 11.8 0.8 1.7 1 0 0 1 1 1 0 Bacterial regulatory helix-turn-helix protein, lysR family CENP-B_N PF04218.13 CCF37258.1 - 0.16 11.6 0.0 0.35 10.5 0.0 1.5 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain adh_short PF00106.25 CCF37259.1 - 1.3e-20 73.7 0.4 3.4e-18 65.8 0.2 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCF37259.1 - 3.3e-14 53.0 0.1 8.3e-12 45.2 0.0 2.2 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF37259.1 - 2.9e-07 30.6 0.1 6.2e-07 29.5 0.1 1.5 1 0 0 1 1 1 1 KR domain Strep_pep PF14404.6 CCF37259.1 - 0.033 14.4 0.1 0.081 13.2 0.1 1.6 1 0 0 1 1 1 0 Ribosomally synthesized peptide in Streptomyces species Spo7 PF03907.13 CCF37261.1 - 6e-95 316.9 0.2 1.2e-94 316.0 0.2 1.5 1 0 0 1 1 1 1 Spo7-like protein p450 PF00067.22 CCF37264.1 - 4e-53 180.8 0.0 5e-53 180.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 NmrA PF05368.13 CCF37265.1 - 6.4e-27 94.6 0.0 1.5e-26 93.4 0.0 1.5 1 1 1 2 2 2 1 NmrA-like family NAD_binding_10 PF13460.6 CCF37265.1 - 2.6e-23 82.8 0.1 4.2e-23 82.2 0.1 1.4 1 1 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 CCF37265.1 - 0.0091 16.3 0.0 0.023 15.0 0.0 1.7 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain HTH_psq PF05225.16 CCF37265.1 - 0.12 12.2 0.0 0.31 10.8 0.0 1.7 2 0 0 2 2 2 0 helix-turn-helix, Psq domain NAD_binding_4 PF07993.12 CCF37266.1 - 6.9e-43 146.7 0.0 1.1e-42 145.9 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.28 CCF37266.1 - 4.7e-36 124.3 0.0 7.8e-36 123.6 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme Epimerase PF01370.21 CCF37266.1 - 5e-11 42.5 0.0 1.4e-10 41.1 0.0 1.8 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family AAA_33 PF13671.6 CCF37266.1 - 1.1e-10 41.8 0.0 2.4e-10 40.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain PP-binding PF00550.25 CCF37266.1 - 9.9e-10 38.6 0.9 3.2e-09 37.0 0.1 2.3 2 0 0 2 2 2 1 Phosphopantetheine attachment site SKI PF01202.22 CCF37266.1 - 6.3e-07 29.6 0.0 1.2e-06 28.8 0.0 1.4 1 0 0 1 1 1 1 Shikimate kinase AAA_18 PF13238.6 CCF37266.1 - 3e-06 27.8 0.0 8e-06 26.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain APS_kinase PF01583.20 CCF37266.1 - 5.4e-05 23.1 0.0 9.8e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 Adenylylsulphate kinase Cytidylate_kin PF02224.18 CCF37266.1 - 6.7e-05 22.7 0.2 0.00086 19.1 0.0 2.5 2 1 1 3 3 2 1 Cytidylate kinase AAA_25 PF13481.6 CCF37266.1 - 0.00022 20.8 0.1 0.00063 19.4 0.1 1.7 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 CCF37266.1 - 0.00034 21.0 0.0 0.00075 19.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain KR PF08659.10 CCF37266.1 - 0.00094 19.1 0.1 0.02 14.8 0.1 2.6 2 0 0 2 2 2 1 KR domain AAA_PrkA PF08298.11 CCF37266.1 - 0.015 14.3 0.0 0.025 13.5 0.0 1.3 1 0 0 1 1 1 0 PrkA AAA domain AAA_16 PF13191.6 CCF37266.1 - 0.022 15.1 0.1 0.077 13.4 0.0 1.9 2 0 0 2 2 1 0 AAA ATPase domain AAA PF00004.29 CCF37266.1 - 0.024 15.0 0.0 0.052 14.0 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.20 CCF37266.1 - 0.036 13.1 0.3 0.52 9.3 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_22 PF13401.6 CCF37266.1 - 0.059 13.6 0.0 0.18 12.1 0.0 1.9 1 0 0 1 1 1 0 AAA domain CoaE PF01121.20 CCF37266.1 - 0.06 13.0 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 Dephospho-CoA kinase dNK PF01712.19 CCF37266.1 - 0.078 12.8 0.1 1.6 8.5 0.0 2.3 2 0 0 2 2 2 0 Deoxynucleoside kinase CPT PF07931.12 CCF37266.1 - 0.082 12.7 0.1 0.29 11.0 0.1 2.0 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein 3Beta_HSD PF01073.19 CCF37266.1 - 0.084 11.9 0.0 0.26 10.3 0.0 1.8 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family IstB_IS21 PF01695.17 CCF37266.1 - 0.084 12.6 0.0 0.19 11.5 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_5 PF07728.14 CCF37266.1 - 0.094 12.7 0.0 0.21 11.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Semialdhyde_dh PF01118.24 CCF37266.1 - 0.099 13.1 0.0 0.26 11.7 0.0 1.7 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain AAA_29 PF13555.6 CCF37266.1 - 0.15 11.9 0.0 0.33 10.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Zeta_toxin PF06414.12 CCF37266.1 - 0.19 11.0 0.0 0.46 9.7 0.0 1.7 1 0 0 1 1 1 0 Zeta toxin DHDPS PF00701.22 CCF37267.1 - 1.4e-37 129.0 0.0 1.6e-37 128.8 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family MFS_1 PF07690.16 CCF37268.1 - 2.7e-30 105.5 22.2 2.7e-30 105.5 22.2 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF2584 PF10763.9 CCF37268.1 - 0.087 13.0 0.0 0.16 12.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2584) STAG PF08514.11 CCF37269.1 - 0.017 15.0 0.7 0.07 13.0 0.7 1.9 1 1 1 2 2 2 0 STAG domain ATG16 PF08614.11 CCF37269.1 - 0.43 10.8 5.2 1.1 9.5 5.2 1.7 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) Acetyltransf_1 PF00583.25 CCF37270.1 - 9.8e-14 51.6 0.0 1.3e-13 51.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CCF37270.1 - 3.1e-10 40.1 0.0 4.7e-10 39.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CCF37270.1 - 4.6e-09 36.6 0.0 6.5e-09 36.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CCF37270.1 - 6.3e-06 26.1 0.0 1e-05 25.4 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 CCF37270.1 - 0.002 18.2 0.0 0.0031 17.6 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 CCF37270.1 - 0.0056 16.8 0.1 0.014 15.6 0.1 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain adh_short_C2 PF13561.6 CCF37271.1 - 2.3e-61 207.4 0.7 2.7e-61 207.1 0.7 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF37271.1 - 2.3e-45 154.5 0.7 2.9e-45 154.1 0.7 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF37271.1 - 1.7e-11 44.3 0.5 2.3e-11 43.9 0.5 1.2 1 0 0 1 1 1 1 KR domain ZapC PF07126.12 CCF37271.1 - 0.063 12.9 0.0 0.1 12.1 0.0 1.3 1 0 0 1 1 1 0 Cell-division protein ZapC 3HCDH_N PF02737.18 CCF37271.1 - 0.086 12.7 0.1 0.13 12.1 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Acyltransferase PF01553.21 CCF37272.1 - 1.1e-32 112.5 0.0 1.7e-32 111.8 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Ribonuc_L-PSP PF01042.21 CCF37272.1 - 0.073 13.1 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Endoribonuclease L-PSP Rap1-DNA-bind PF09197.10 CCF37273.1 - 0.039 14.6 0.0 0.054 14.1 0.0 1.3 1 0 0 1 1 1 0 Rap1, DNA-binding ATP-synt_DE_N PF02823.16 CCF37276.1 - 1.3e-16 60.3 0.0 2.1e-16 59.6 0.0 1.3 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain F-box_4 PF15966.5 CCF37277.1 - 0.001 18.9 0.0 0.0027 17.6 0.0 1.8 1 0 0 1 1 1 1 F-box F-box PF00646.33 CCF37277.1 - 0.032 14.1 0.1 0.092 12.7 0.1 1.8 1 0 0 1 1 1 0 F-box domain DUF3759 PF12585.8 CCF37278.1 - 0.12 12.4 0.0 0.2 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3759) Na_H_Exchanger PF00999.21 CCF37279.1 - 1.6e-33 116.1 10.7 2e-33 115.7 10.7 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family YrhC PF14143.6 CCF37279.1 - 0.094 12.8 0.1 0.094 12.8 0.1 3.0 4 0 0 4 4 4 0 YrhC-like protein OCD_Mu_crystall PF02423.15 CCF37280.1 - 1.2e-09 37.5 0.2 8.5e-05 21.6 0.0 2.8 3 0 0 3 3 3 2 Ornithine cyclodeaminase/mu-crystallin family Trehalase PF01204.18 CCF37281.1 - 3.3e-07 29.5 3.3 4e-07 29.2 3.3 1.1 1 0 0 1 1 1 1 Trehalase Band_7 PF01145.25 CCF37283.1 - 1.4e-23 83.8 3.0 2.2e-23 83.2 3.0 1.4 1 0 0 1 1 1 1 SPFH domain / Band 7 family ubiquitin PF00240.23 CCF37284.1 - 3.8e-25 87.4 0.2 4.2e-25 87.3 0.2 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 CCF37284.1 - 2.5e-13 49.7 0.1 2.7e-13 49.5 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 CCF37284.1 - 0.00021 21.7 0.1 0.00077 19.9 0.1 1.7 1 1 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 CCF37284.1 - 0.0032 17.4 0.0 0.0038 17.1 0.0 1.1 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_4 PF18036.1 CCF37284.1 - 0.023 14.8 0.3 3.3 7.8 0.2 2.0 2 0 0 2 2 2 0 Ubiquitin-like domain JmjC PF02373.22 CCF37285.1 - 2.5e-10 40.8 0.1 8.2e-10 39.1 0.1 1.9 1 0 0 1 1 1 1 JmjC domain, hydroxylase zf-4CXXC_R1 PF10497.9 CCF37285.1 - 9.7e-09 35.4 11.6 9.7e-09 35.4 11.6 2.7 2 0 0 2 2 2 1 Zinc-finger domain of monoamine-oxidase A repressor R1 Cupin_2 PF07883.11 CCF37285.1 - 0.0029 17.3 0.0 0.0071 16.0 0.0 1.6 1 0 0 1 1 1 1 Cupin domain AT_hook PF02178.19 CCF37285.1 - 0.12 12.3 19.9 1.1 9.4 4.9 3.1 2 0 0 2 2 2 0 AT hook motif WD40 PF00400.32 CCF37286.1 - 2.8e-28 97.6 8.8 4.1e-05 24.3 0.1 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat F-box-like PF12937.7 CCF37286.1 - 1.9e-12 46.9 0.5 4.9e-12 45.5 0.5 1.8 1 0 0 1 1 1 1 F-box-like ANAPC4_WD40 PF12894.7 CCF37286.1 - 1.9e-06 28.1 0.9 0.13 12.6 0.0 3.9 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain F-box PF00646.33 CCF37286.1 - 2e-05 24.3 0.1 8.1e-05 22.4 0.1 2.0 2 0 0 2 2 2 1 F-box domain F-box_4 PF15966.5 CCF37286.1 - 0.04 13.8 0.0 0.098 12.5 0.0 1.6 1 0 0 1 1 1 0 F-box Nup160 PF11715.8 CCF37286.1 - 0.19 10.3 2.4 3.5 6.2 0.0 2.6 3 0 0 3 3 3 0 Nucleoporin Nup120/160 YTH PF04146.15 CCF37288.1 - 2.6e-62 209.6 0.2 5.7e-62 208.5 0.0 1.7 2 0 0 2 2 2 1 YT521-B-like domain RRM_1 PF00076.22 CCF37288.1 - 0.0025 17.6 0.0 0.0069 16.2 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CCF37288.1 - 0.15 11.9 0.0 0.38 10.6 0.0 1.6 1 0 0 1 1 1 0 Occluded RNA-recognition motif Aldo_ket_red PF00248.21 CCF37289.1 - 3.4e-13 49.4 0.0 3.9e-13 49.3 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family GPP34 PF05719.11 CCF37290.1 - 4.3e-70 235.9 0.2 5.4e-70 235.6 0.2 1.1 1 0 0 1 1 1 1 Golgi phosphoprotein 3 (GPP34) SURF6 PF04935.12 CCF37291.1 - 1.5e-44 152.2 24.8 1.9e-44 151.9 24.8 1.1 1 0 0 1 1 1 1 Surfeit locus protein 6 DUF3584 PF12128.8 CCF37291.1 - 2.8 5.3 17.1 3.3 5.1 17.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Rpr2 PF04032.16 CCF37292.1 - 3.2e-13 49.8 0.9 5.3e-13 49.1 0.1 1.7 2 0 0 2 2 2 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain zf-PHD-like PF15446.6 CCF37292.1 - 0.019 14.6 1.0 0.024 14.2 1.0 1.3 1 0 0 1 1 1 0 PHD/FYVE-zinc-finger like domain Nudix_N_2 PF14803.6 CCF37292.1 - 0.09 12.7 2.6 0.29 11.1 0.6 2.4 2 0 0 2 2 2 0 Nudix N-terminal Zn_Tnp_IS1595 PF12760.7 CCF37292.1 - 0.17 11.9 1.2 2.8 8.0 0.2 2.3 2 0 0 2 2 2 0 Transposase zinc-ribbon domain zf-RING_7 PF02591.15 CCF37292.1 - 3.4 7.9 6.4 3.4 7.9 0.1 3.1 2 1 1 3 3 3 0 C4-type zinc ribbon domain Met_10 PF02475.16 CCF37293.1 - 8.3e-05 22.4 0.0 0.00076 19.3 0.0 2.2 1 1 0 1 1 1 1 Met-10+ like-protein EF-hand_6 PF13405.6 CCF37294.1 - 3e-07 29.8 0.6 0.032 14.2 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 CCF37294.1 - 1.7e-05 25.2 5.8 0.00099 19.5 0.9 1.8 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 CCF37294.1 - 5e-05 22.6 0.0 0.00022 20.6 0.0 2.0 2 0 0 2 2 2 1 EF hand EF-hand_1 PF00036.32 CCF37294.1 - 0.00011 21.5 0.1 0.00086 18.7 0.0 2.2 2 0 0 2 2 2 1 EF hand PepSY_2 PF13670.6 CCF37294.1 - 0.14 12.2 0.5 0.25 11.4 0.0 1.7 2 0 0 2 2 2 0 Peptidase propeptide and YPEB domain ORC6 PF05460.13 CCF37295.1 - 7.9e-38 130.6 0.0 3.3e-37 128.6 0.0 1.8 1 1 0 1 1 1 1 Origin recognition complex subunit 6 (ORC6) SelB-wing_2 PF09106.11 CCF37295.1 - 0.13 12.5 0.1 0.38 11.0 0.1 1.8 1 0 0 1 1 1 0 Elongation factor SelB, winged helix Tyrosinase PF00264.20 CCF37296.1 - 2.3e-54 185.1 0.0 3.1e-54 184.6 0.0 1.2 1 0 0 1 1 1 1 Common central domain of tyrosinase Fungal_trans PF04082.18 CCF37297.1 - 2.1e-09 36.8 0.2 4.3e-09 35.8 0.0 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain DUF1127 PF06568.11 CCF37297.1 - 5.7 6.7 9.2 2 8.2 0.7 3.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1127) ADH_zinc_N PF00107.26 CCF37298.1 - 4.6e-23 81.6 0.9 9.2e-23 80.6 0.9 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCF37298.1 - 1.4e-13 52.1 0.0 2.5e-13 51.2 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCF37298.1 - 1.3e-08 34.6 0.0 1.1e-07 31.6 0.0 2.3 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_N_2 PF16884.5 CCF37298.1 - 0.17 11.8 0.0 0.45 10.4 0.0 1.7 1 0 0 1 1 1 0 N-terminal domain of oxidoreductase Na_Ca_ex PF01699.24 CCF37299.1 - 2e-30 105.7 31.6 2e-17 63.5 17.2 2.4 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Conotoxin PF02950.17 CCF37300.1 - 0.11 13.6 2.5 0.14 13.2 2.5 1.3 1 0 0 1 1 1 0 Conotoxin P21-Arc PF04062.14 CCF37301.1 - 3.5e-09 36.9 0.0 2.1e-08 34.4 0.0 1.9 1 1 1 2 2 2 1 ARP2/3 complex ARPC3 (21 kDa) subunit TnpW PF14202.6 CCF37302.1 - 0.12 12.2 0.2 0.84 9.5 0.1 2.2 2 0 0 2 2 2 0 Transposon-encoded protein TnpW MR_MLE_C PF13378.6 CCF37303.1 - 5.8e-61 205.9 0.1 7.4e-61 205.5 0.1 1.0 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 CCF37303.1 - 4.6e-10 39.7 0.0 1.1e-09 38.5 0.0 1.6 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain Fungal_trans_2 PF11951.8 CCF37304.1 - 0.00018 20.5 0.0 0.00059 18.8 0.0 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain ResIII PF04851.15 CCF37306.1 - 3.6e-26 92.2 0.0 8.5e-26 91.0 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 CCF37306.1 - 3.5e-11 43.2 0.0 8.1e-11 42.0 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF37306.1 - 2.6e-08 34.2 0.1 1.8e-06 28.3 0.1 2.8 2 1 0 2 2 2 1 Helicase conserved C-terminal domain SWI2_SNF2 PF18766.1 CCF37306.1 - 5.6e-05 22.9 0.0 0.00012 21.9 0.0 1.5 1 0 0 1 1 1 1 SWI2/SNF2 ATPase DUF2075 PF09848.9 CCF37306.1 - 0.008 15.5 0.0 0.014 14.6 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) SwrA PF17423.2 CCF37306.1 - 0.013 15.5 0.0 0.036 14.0 0.0 1.7 1 0 0 1 1 1 0 Swarming motility protein DUF3328 PF11807.8 CCF37307.1 - 6.3e-21 75.2 3.1 6.7e-21 75.1 1.4 1.9 1 1 1 2 2 2 1 Domain of unknown function (DUF3328) Baculo_PEP_C PF04513.12 CCF37308.1 - 3.1 7.8 11.0 0.29 11.2 2.1 2.5 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF202 PF02656.15 CCF37309.1 - 2.5e-22 79.1 0.9 2.5e-22 79.1 0.9 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF202) SPX PF03105.19 CCF37309.1 - 2.6 7.8 9.8 3.5 7.5 9.8 1.1 1 0 0 1 1 1 0 SPX domain Diphthami_syn_2 PF01902.17 CCF37310.1 - 4.6e-20 72.1 0.0 4e-16 59.2 0.0 3.4 2 1 0 2 2 2 2 Diphthamide synthase Ribonuc_L-PSP PF01042.21 CCF37310.1 - 6e-11 42.4 0.0 1.2e-06 28.5 0.0 4.1 4 0 0 4 4 4 2 Endoribonuclease L-PSP Uma2 PF05685.12 CCF37310.1 - 0.14 11.7 0.3 0.34 10.4 0.3 1.6 1 0 0 1 1 1 0 Putative restriction endonuclease Rho_GDI PF02115.17 CCF37311.1 - 2.6e-49 167.6 0.2 2.8e-49 167.5 0.2 1.0 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor E1_DerP2_DerF2 PF02221.15 CCF37311.1 - 0.051 14.0 0.0 0.11 13.0 0.0 1.6 1 1 0 1 1 1 0 ML domain Metallophos PF00149.28 CCF37312.1 - 5.2e-37 128.3 0.7 7e-37 127.9 0.7 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CCF37312.1 - 0.13 12.4 0.0 0.22 11.7 0.0 1.3 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain STPPase_N PF16891.5 CCF37312.1 - 0.17 12.3 0.2 0.46 11.0 0.2 1.7 1 1 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain ABC_membrane PF00664.23 CCF37313.1 - 2.9e-41 142.0 12.1 3.6e-41 141.6 12.1 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 CCF37313.1 - 2.9e-34 118.5 0.0 1.5e-33 116.2 0.0 2.0 2 0 0 2 2 2 1 ABC transporter AAA_16 PF13191.6 CCF37313.1 - 4.2e-06 27.2 0.0 9.1e-06 26.1 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain SMC_N PF02463.19 CCF37313.1 - 1.5e-05 24.6 0.0 0.003 17.0 0.0 2.3 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 CCF37313.1 - 0.00035 20.9 0.0 0.0017 18.6 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_21 PF13304.6 CCF37313.1 - 0.0017 18.2 0.1 0.057 13.2 0.0 2.3 1 1 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system MMR_HSR1 PF01926.23 CCF37313.1 - 0.0022 18.1 0.0 0.0076 16.3 0.0 2.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CCF37313.1 - 0.0024 17.8 0.0 0.013 15.5 0.0 2.0 2 0 0 2 2 2 1 RsgA GTPase AAA_14 PF13173.6 CCF37313.1 - 0.004 17.2 0.0 0.028 14.4 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 CCF37313.1 - 0.022 15.2 0.0 0.1 13.0 0.0 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 CCF37313.1 - 0.025 14.2 0.0 0.055 13.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 CCF37313.1 - 0.028 13.7 0.0 0.089 12.1 0.0 1.8 1 0 0 1 1 1 0 Zeta toxin AAA_7 PF12775.7 CCF37313.1 - 0.031 13.8 0.1 0.093 12.2 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_33 PF13671.6 CCF37313.1 - 0.032 14.4 0.0 0.08 13.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 CCF37313.1 - 0.038 13.7 0.0 0.1 12.4 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain Tir_receptor_C PF07489.11 CCF37313.1 - 0.054 13.5 1.2 0.1 12.5 1.2 1.4 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus AAA_18 PF13238.6 CCF37313.1 - 0.068 13.7 0.0 0.23 12.0 0.0 2.0 2 0 0 2 2 1 0 AAA domain AAA_28 PF13521.6 CCF37313.1 - 0.069 13.4 0.0 0.16 12.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 CCF37313.1 - 0.07 13.0 0.0 0.18 11.7 0.0 1.7 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea Rad17 PF03215.15 CCF37313.1 - 0.077 12.9 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain SbcCD_C PF13558.6 CCF37313.1 - 0.083 13.1 0.5 1.8 8.8 0.5 2.5 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit Septin PF00735.18 CCF37313.1 - 0.094 12.0 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 Septin AAA_15 PF13175.6 CCF37313.1 - 0.1 12.3 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_30 PF13604.6 CCF37313.1 - 0.11 12.2 0.0 0.23 11.1 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 CCF37313.1 - 0.14 11.9 0.0 0.39 10.4 0.0 1.7 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 CCF37313.1 - 0.17 11.8 0.3 0.51 10.2 0.0 2.0 3 0 0 3 3 2 0 NACHT domain UPF0176_N PF17773.1 CCF37314.1 - 0.041 14.3 0.0 0.048 14.0 0.0 1.1 1 0 0 1 1 1 0 UPF0176 acylphosphatase like domain Sugar_tr PF00083.24 CCF37315.1 - 4.8e-90 302.6 18.3 5.5e-90 302.4 18.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF37315.1 - 1e-18 67.4 38.5 1.3e-12 47.3 10.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DEAD PF00270.29 CCF37316.1 - 4.4e-48 163.4 0.0 1.5e-47 161.6 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF37316.1 - 7.3e-34 116.5 0.0 4e-31 107.6 0.0 2.6 3 0 0 3 3 3 2 Helicase conserved C-terminal domain ResIII PF04851.15 CCF37316.1 - 5.5e-05 23.2 0.1 0.00018 21.5 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 CCF37316.1 - 0.00023 20.4 0.0 0.00023 20.4 0.0 1.7 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase SecA_DEAD PF07517.14 CCF37316.1 - 0.0012 18.2 0.0 0.0057 16.0 0.0 2.1 2 0 0 2 2 2 1 SecA DEAD-like domain UTP25 PF06862.12 CCF37316.1 - 0.042 12.6 0.0 0.087 11.6 0.0 1.5 1 0 0 1 1 1 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 Peptidase_S49_N PF08496.10 CCF37316.1 - 0.083 13.0 1.5 0.16 12.0 1.5 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal CMS1 PF14617.6 CCF37316.1 - 2.5 7.4 7.8 39 3.5 0.0 2.5 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit AP3D1 PF06375.11 CCF37316.1 - 4.7 7.4 11.3 8.4 6.6 11.3 1.4 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Rft-1 PF04506.13 CCF37317.1 - 1.2e-150 502.7 12.9 1.3e-150 502.5 12.9 1.0 1 0 0 1 1 1 1 Rft protein Polysacc_synt_3 PF13440.6 CCF37317.1 - 0.0011 18.2 0.4 0.0011 18.2 0.4 3.1 2 1 1 3 3 3 2 Polysaccharide biosynthesis protein adh_short PF00106.25 CCF37318.1 - 3e-25 88.8 0.7 7.3e-24 84.3 0.7 2.1 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF37318.1 - 9.9e-19 67.8 0.3 2.7e-17 63.1 0.3 2.1 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF37318.1 - 0.00014 21.8 2.2 0.00033 20.6 2.2 1.6 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF37318.1 - 0.0024 17.4 0.6 0.027 13.9 0.6 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF3425 PF11905.8 CCF37319.1 - 2.5e-14 53.3 0.0 6.1e-14 52.1 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) DnaJ PF00226.31 CCF37320.1 - 4.8e-07 29.8 0.0 9.7e-07 28.8 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain MARVEL PF01284.23 CCF37321.1 - 0.0013 18.8 1.4 0.0023 18.0 1.4 1.5 1 1 0 1 1 1 1 Membrane-associating domain Peptidase_C2 PF00648.21 CCF37322.1 - 2.2e-16 59.7 0.0 3.4e-16 59.1 0.0 1.3 1 0 0 1 1 1 1 Calpain family cysteine protease Peptidase_C1 PF00112.23 CCF37322.1 - 0.053 13.6 0.3 0.086 12.9 0.3 1.3 1 0 0 1 1 1 0 Papain family cysteine protease CobT PF06213.12 CCF37323.1 - 0.14 11.5 18.8 0.15 11.4 18.8 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT MRP-S26 PF14943.6 CCF37323.1 - 0.25 11.2 13.7 0.28 11.1 13.7 1.0 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 Spt20 PF12090.8 CCF37323.1 - 0.26 10.9 43.1 0.28 10.8 43.1 1.1 1 0 0 1 1 1 0 Spt20 family SpoIIP PF07454.11 CCF37323.1 - 0.62 9.5 15.5 0.64 9.4 15.5 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF4518 PF15008.6 CCF37323.1 - 0.66 9.1 18.0 0.77 8.9 18.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4518) Paf1 PF03985.13 CCF37323.1 - 0.66 8.9 15.5 0.68 8.9 15.5 1.0 1 0 0 1 1 1 0 Paf1 DUF4820 PF16091.5 CCF37323.1 - 0.66 9.3 12.1 0.68 9.3 12.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) DUF2722 PF10846.8 CCF37323.1 - 0.7 8.8 35.9 0.76 8.7 35.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) TERB2 PF15101.6 CCF37323.1 - 0.75 9.8 21.4 0.71 9.9 21.4 1.0 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Presenilin PF01080.17 CCF37323.1 - 0.75 8.5 15.8 0.76 8.5 15.8 1.0 1 0 0 1 1 1 0 Presenilin MPM1 PF17234.2 CCF37323.1 - 0.78 10.0 16.9 0.86 9.8 16.9 1.1 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 Rxt3 PF08642.10 CCF37323.1 - 1 10.1 9.4 1.1 10.0 9.4 1.1 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 CPSF100_C PF13299.6 CCF37323.1 - 1.1 9.4 11.8 1.1 9.4 11.8 1.0 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal CCDC53 PF10152.9 CCF37323.1 - 1.1 9.6 14.0 1.2 9.5 14.0 1.0 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex FAM176 PF14851.6 CCF37323.1 - 1.2 8.8 9.3 1.3 8.7 9.3 1.0 1 0 0 1 1 1 0 FAM176 family BRF1 PF07741.13 CCF37323.1 - 1.2 9.5 12.5 1.1 9.6 12.5 1.1 1 0 0 1 1 1 0 Brf1-like TBP-binding domain AIF_C PF14721.6 CCF37323.1 - 1.3 9.4 11.6 1.5 9.2 11.6 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term ATP-synt_E PF05680.12 CCF37323.1 - 1.3 9.4 13.6 1.9 8.9 13.6 1.2 1 0 0 1 1 1 0 ATP synthase E chain Peptidase_S49_N PF08496.10 CCF37323.1 - 1.3 9.0 11.2 1.3 9.0 11.2 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal RED_N PF07808.13 CCF37323.1 - 1.4 8.4 17.5 1.5 8.3 17.5 1.0 1 0 0 1 1 1 0 RED-like protein N-terminal region DUF4834 PF16118.5 CCF37323.1 - 1.4 9.9 19.2 2.1 9.4 19.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DUF4746 PF15928.5 CCF37323.1 - 1.6 8.1 11.2 1.6 8.1 11.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) EIIBC-GUT_N PF03612.14 CCF37323.1 - 1.7 8.4 14.1 1.7 8.3 14.1 1.0 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DDHD PF02862.17 CCF37323.1 - 1.8 8.7 13.7 1.8 8.6 13.7 1.0 1 0 0 1 1 1 0 DDHD domain WASH-7_C PF14746.6 CCF37323.1 - 1.9 8.2 15.0 2.1 8.0 15.0 1.1 1 0 0 1 1 1 0 WASH complex subunit 7, C-terminal MTP18 PF10558.9 CCF37323.1 - 2.1 8.3 8.7 2.1 8.2 8.7 1.0 1 0 0 1 1 1 0 Mitochondrial 18 KDa protein (MTP18) RPA43_OB PF17875.1 CCF37323.1 - 2.1 9.0 13.2 2.1 9.0 13.2 1.0 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I Pex14_N PF04695.13 CCF37323.1 - 2.2 8.9 24.4 2.4 8.8 24.4 1.0 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region MMU163 PF17119.5 CCF37323.1 - 2.2 7.4 7.9 2.1 7.4 7.9 1.0 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis Tim54 PF11711.8 CCF37323.1 - 2.3 6.9 12.9 2.3 6.9 12.9 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF702 PF05142.12 CCF37323.1 - 2.3 8.7 14.9 2.5 8.6 14.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF702) RNA_pol_Rbc25 PF08292.12 CCF37323.1 - 2.3 8.4 11.1 2.6 8.3 11.1 1.1 1 0 0 1 1 1 0 RNA polymerase III subunit Rpc25 EOS1 PF12326.8 CCF37323.1 - 2.5 8.0 9.1 2.8 7.8 9.1 1.0 1 0 0 1 1 1 0 N-glycosylation protein RR_TM4-6 PF06459.12 CCF37323.1 - 2.5 7.9 16.2 2.8 7.7 16.2 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CTU2 PF10288.9 CCF37323.1 - 2.5 8.4 14.2 2.8 8.2 14.2 1.1 1 0 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 FHIPEP PF00771.20 CCF37323.1 - 2.7 6.3 10.4 2.6 6.4 10.4 1.0 1 0 0 1 1 1 0 FHIPEP family DUF2828 PF11443.8 CCF37323.1 - 2.9 5.9 13.7 3.2 5.7 13.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Connexin PF00029.19 CCF37323.1 - 2.9 7.6 12.7 3 7.5 12.7 1.0 1 0 0 1 1 1 0 Connexin Sec62 PF03839.16 CCF37323.1 - 3.1 7.3 10.2 3.2 7.2 10.2 1.0 1 0 0 1 1 1 0 Translocation protein Sec62 DUF4407 PF14362.6 CCF37323.1 - 3.2 7.0 16.7 3.6 6.8 16.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SLC12 PF03522.15 CCF37323.1 - 3.4 6.6 14.3 3.3 6.6 14.3 1.0 1 0 0 1 1 1 0 Solute carrier family 12 FAM60A PF15396.6 CCF37323.1 - 3.4 7.6 10.7 3.4 7.6 10.7 1.0 1 0 0 1 1 1 0 Protein Family FAM60A DUF3464 PF11947.8 CCF37323.1 - 3.4 7.4 15.4 3.9 7.2 15.4 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Ureide_permease PF07168.11 CCF37323.1 - 3.4 6.3 6.9 3.5 6.3 6.9 1.0 1 0 0 1 1 1 0 Ureide permease TFIIA PF03153.13 CCF37323.1 - 3.5 7.5 38.0 3.2 7.6 38.0 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit G0-G1_switch_2 PF15103.6 CCF37323.1 - 3.5 8.1 11.2 4.1 7.9 11.2 1.1 1 0 0 1 1 1 0 G0/G1 switch protein 2 EPL1 PF10513.9 CCF37323.1 - 3.7 7.9 17.5 4.1 7.8 17.5 1.1 1 0 0 1 1 1 0 Enhancer of polycomb-like Orf78 PF06024.12 CCF37323.1 - 3.7 7.9 10.6 4.4 7.7 10.6 1.1 1 0 0 1 1 1 0 Orf78 (ac78) MDM10 PF12519.8 CCF37323.1 - 3.9 6.2 12.9 3.6 6.3 12.9 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Gti1_Pac2 PF09729.9 CCF37323.1 - 4.1 7.5 12.9 4.1 7.5 12.9 1.0 1 0 0 1 1 1 0 Gti1/Pac2 family Folate_carrier PF01770.18 CCF37323.1 - 4.1 6.0 9.8 4.4 5.9 9.8 1.0 1 0 0 1 1 1 0 Reduced folate carrier Otopetrin PF03189.13 CCF37323.1 - 4.2 6.1 9.3 4.5 6.0 9.3 1.0 1 0 0 1 1 1 0 Otopetrin Renin_r PF07850.14 CCF37323.1 - 4.2 8.0 6.1 5 7.8 6.1 1.3 1 0 0 1 1 1 0 Renin receptor-like protein PPL5 PF18168.1 CCF37323.1 - 4.5 6.5 10.3 4 6.7 10.3 1.0 1 0 0 1 1 1 0 Prim-pol family 5 HA2 PF04408.23 CCF37323.1 - 4.7 7.5 7.5 5.3 7.4 7.5 1.2 1 0 0 1 1 1 0 Helicase associated domain (HA2) Band_3_cyto PF07565.13 CCF37323.1 - 4.8 6.9 14.9 5.1 6.8 14.9 1.0 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Suf PF05843.14 CCF37323.1 - 5.2 7.0 20.4 5.4 6.9 20.4 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Neur_chan_memb PF02932.16 CCF37323.1 - 5.3 7.0 10.9 5.3 7.0 10.9 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region V_ATPase_I PF01496.19 CCF37323.1 - 5.3 4.8 16.7 5.2 4.9 16.7 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF1075 PF06388.11 CCF37323.1 - 5.5 7.1 8.6 6.4 6.8 8.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1075) CLN3 PF02487.17 CCF37323.1 - 5.8 5.9 12.2 5.7 5.9 12.2 1.0 1 0 0 1 1 1 0 CLN3 protein DUF2367 PF10164.9 CCF37323.1 - 5.8 7.5 10.2 6.7 7.3 10.2 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2367) Coilin_N PF15862.5 CCF37323.1 - 6 6.7 17.8 7.4 6.4 17.8 1.2 1 0 0 1 1 1 0 Coilin N-terminus DUF4175 PF13779.6 CCF37323.1 - 6 4.6 34.3 6.3 4.6 34.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) YABBY PF04690.13 CCF37323.1 - 6.3 7.3 11.4 5.8 7.5 11.4 1.0 1 0 0 1 1 1 0 YABBY protein ALMT PF11744.8 CCF37323.1 - 6.3 5.5 12.0 6 5.6 12.0 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter FAM91_C PF14648.6 CCF37323.1 - 6.5 5.5 10.0 6.6 5.5 10.0 1.0 1 0 0 1 1 1 0 FAM91 C-terminus PIP5K PF01504.18 CCF37323.1 - 6.8 5.8 13.8 7.1 5.8 13.8 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase eIF-3_zeta PF05091.12 CCF37323.1 - 7.1 5.5 23.0 6.6 5.6 23.0 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4770 PF15994.5 CCF37323.1 - 7.1 6.8 18.5 7.3 6.8 18.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) Ctr PF04145.15 CCF37323.1 - 7.2 7.2 10.4 7.1 7.2 10.4 1.0 1 0 0 1 1 1 0 Ctr copper transporter family DUF2126 PF09899.9 CCF37323.1 - 7.5 4.5 11.0 7.8 4.4 11.0 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) FlaG PF03646.15 CCF37323.1 - 8.2 6.7 22.1 12 6.2 22.1 1.3 1 0 0 1 1 1 0 FlaG protein CSG2 PF16965.5 CCF37323.1 - 8.8 5.2 9.3 8.7 5.2 9.3 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator PAT1 PF09770.9 CCF37323.1 - 8.8 4.5 26.0 9.2 4.4 26.0 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Hid1 PF12722.7 CCF37323.1 - 9.3 4.2 13.5 8.8 4.3 13.5 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein FAM150 PF15129.6 CCF37323.1 - 9.4 6.4 14.2 9.4 6.4 14.2 1.1 1 0 0 1 1 1 0 FAM150 family Kei1 PF08552.11 CCF37323.1 - 9.5 6.0 10.4 10 5.9 10.4 1.0 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 EVC2_like PF12297.8 CCF37324.1 - 0.94 8.1 1.7 1.1 7.8 1.7 1.1 1 0 0 1 1 1 0 Ellis van Creveld protein 2 like protein DAHP_synth_1 PF00793.20 CCF37325.1 - 4.7e-103 343.8 0.1 5.9e-103 343.5 0.1 1.0 1 0 0 1 1 1 1 DAHP synthetase I family YIEGIA PF14045.6 CCF37325.1 - 0.19 10.5 0.1 0.34 9.7 0.1 1.3 1 0 0 1 1 1 0 YIEGIA protein Ribosomal_L50 PF10501.9 CCF37327.1 - 7.8e-17 61.4 0.0 1.5e-16 60.5 0.0 1.5 1 0 0 1 1 1 1 Ribosomal subunit 39S Sugarporin_N PF11471.8 CCF37327.1 - 0.31 11.0 10.3 1.5 8.8 7.7 2.5 2 0 0 2 2 2 0 Maltoporin periplasmic N-terminal extension HSP70 PF00012.20 CCF37328.1 - 9.1e-224 744.1 8.0 1e-223 743.9 8.0 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 CCF37328.1 - 4.4e-16 58.6 0.3 4e-15 55.5 0.1 2.0 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 CCF37328.1 - 0.0051 16.6 0.0 0.012 15.3 0.0 1.6 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain DNA_mis_repair PF01119.19 CCF37330.1 - 4.4e-33 113.5 0.0 6.5e-33 112.9 0.0 1.2 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 CCF37330.1 - 1.5e-11 44.3 0.0 3e-11 43.3 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 CCF37330.1 - 2.6e-05 24.7 0.0 5.8e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Thioredoxin_8 PF13905.6 CCF37330.1 - 0.042 14.2 0.0 0.077 13.3 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin-like Beta-lactamase PF00144.24 CCF37331.1 - 3.8e-54 184.2 0.0 4.4e-54 183.9 0.0 1.0 1 0 0 1 1 1 1 Beta-lactamase Cu-oxidase_3 PF07732.15 CCF37333.1 - 9.8e-49 164.3 5.1 3.1e-46 156.3 1.0 2.3 2 0 0 2 2 2 2 Multicopper oxidase Cu-oxidase PF00394.22 CCF37333.1 - 2.3e-28 99.3 0.1 2.5e-27 95.9 0.0 2.4 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 CCF37333.1 - 0.00059 19.6 7.9 0.0049 16.6 3.0 3.2 2 1 0 2 2 2 1 Multicopper oxidase SARAF PF06682.12 CCF37333.1 - 0.0091 15.7 0.0 0.015 14.9 0.0 1.3 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis FAD_binding_4 PF01565.23 CCF37334.1 - 1.9e-18 66.6 1.8 1.9e-18 66.6 1.8 1.9 2 0 0 2 2 2 1 FAD binding domain MMR_HSR1 PF01926.23 CCF37335.1 - 5.2e-11 42.6 0.0 8.7e-11 41.9 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CCF37335.1 - 0.001 18.6 0.1 0.0024 17.4 0.1 1.6 1 1 0 1 1 1 1 Ferrous iron transport protein B MeaB PF03308.16 CCF37335.1 - 0.0095 14.9 0.1 0.016 14.2 0.1 1.4 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB RsgA_GTPase PF03193.16 CCF37335.1 - 0.013 15.4 0.6 0.049 13.5 0.6 1.9 1 1 0 1 1 1 0 RsgA GTPase Arf PF00025.21 CCF37335.1 - 0.044 13.2 0.0 0.075 12.5 0.0 1.3 1 0 0 1 1 1 0 ADP-ribosylation factor family AAA_25 PF13481.6 CCF37335.1 - 0.11 12.0 0.1 0.52 9.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 CCF37335.1 - 0.12 12.9 0.2 0.47 11.0 0.1 1.9 2 0 0 2 2 2 0 AAA domain PHD PF00628.29 CCF37336.1 - 1.6e-09 37.5 2.3 3.5e-09 36.4 2.3 1.6 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 CCF37336.1 - 0.0013 18.3 3.1 0.0021 17.6 3.1 1.4 1 0 0 1 1 1 1 PHD-finger UIM PF02809.20 CCF37336.1 - 0.0017 18.1 3.4 0.0048 16.7 3.4 1.8 1 0 0 1 1 1 1 Ubiquitin interaction motif CEBP_ZZ PF16366.5 CCF37336.1 - 0.087 13.1 1.9 0.19 12.0 1.9 1.6 1 0 0 1 1 1 0 Cytoplasmic polyadenylation element-binding protein ZZ domain zf-CW PF07496.15 CCF37336.1 - 0.097 12.7 1.1 0.23 11.5 1.1 1.6 1 0 0 1 1 1 0 CW-type Zinc Finger SNF2_N PF00176.23 CCF37337.1 - 1.1e-53 182.2 0.0 1.9e-53 181.4 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CCF37337.1 - 3.4e-18 66.0 0.1 8.5e-18 64.7 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCF37337.1 - 3.4e-05 23.9 0.0 0.00014 21.9 0.0 2.1 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 CCF37337.1 - 7.8e-05 22.0 0.8 0.00025 20.3 0.0 2.0 1 1 1 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase UBA PF00627.31 CCF37337.1 - 9.1e-05 22.3 0.0 0.00026 20.8 0.0 1.8 1 0 0 1 1 1 1 UBA/TS-N domain HBS1_N PF08938.10 CCF37337.1 - 0.048 14.0 2.4 0.07 13.4 0.0 2.5 2 0 0 2 2 2 0 HBS1 N-terminus VMA21 PF09446.10 CCF37338.1 - 5.4e-16 58.4 9.3 7.8e-16 57.9 9.3 1.3 1 0 0 1 1 1 1 VMA21-like domain bZIP_1 PF00170.21 CCF37339.1 - 1.1e-05 25.5 11.9 0.0015 18.6 0.5 3.4 2 1 1 3 3 3 2 bZIP transcription factor TMF_DNA_bd PF12329.8 CCF37339.1 - 0.0018 18.2 12.8 0.15 12.1 2.9 3.1 2 1 1 3 3 3 2 TATA element modulatory factor 1 DNA binding EzrA PF06160.12 CCF37339.1 - 0.003 15.8 11.3 0.0068 14.6 4.1 2.1 1 1 1 2 2 2 2 Septation ring formation regulator, EzrA DUF724 PF05266.14 CCF37339.1 - 0.0061 16.4 7.3 0.0061 16.4 7.3 1.9 1 1 1 2 2 2 1 Protein of unknown function (DUF724) HMMR_N PF15905.5 CCF37339.1 - 0.0062 16.1 10.4 0.0068 15.9 7.0 1.9 1 1 1 2 2 2 2 Hyaluronan mediated motility receptor N-terminal CEP63 PF17045.5 CCF37339.1 - 0.0076 16.2 14.7 0.26 11.2 4.0 2.9 1 1 2 3 3 3 2 Centrosomal protein of 63 kDa Csm1_N PF18504.1 CCF37339.1 - 0.011 16.0 14.8 1.9 8.8 1.2 4.1 1 1 3 4 4 4 0 Csm1 N-terminal domain TPR_MLP1_2 PF07926.12 CCF37339.1 - 0.012 15.7 18.7 0.042 13.9 13.5 2.4 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein ATG16 PF08614.11 CCF37339.1 - 0.012 15.9 18.8 0.14 12.4 18.8 2.2 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) Spc7 PF08317.11 CCF37339.1 - 0.014 14.3 14.8 0.0076 15.2 11.0 1.8 1 1 1 2 2 2 0 Spc7 kinetochore protein Bap31_Bap29_C PF18035.1 CCF37339.1 - 0.015 15.3 3.1 1.4 9.0 0.4 2.6 2 0 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain DUF1192 PF06698.11 CCF37339.1 - 0.019 15.0 7.7 2 8.5 0.2 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) ZapB PF06005.12 CCF37339.1 - 0.022 15.2 17.9 15 6.1 12.4 3.3 1 1 0 2 2 2 0 Cell division protein ZapB DUF1664 PF07889.12 CCF37339.1 - 0.03 14.4 1.8 0.03 14.4 1.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF4618 PF15397.6 CCF37339.1 - 0.03 13.8 13.4 0.21 11.0 5.8 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4618) Mod_r PF07200.13 CCF37339.1 - 0.031 14.4 15.8 0.48 10.5 4.0 2.8 1 1 2 3 3 3 0 Modifier of rudimentary (Mod(r)) protein Atg14 PF10186.9 CCF37339.1 - 0.032 13.3 11.7 0.074 12.1 11.7 1.5 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Fib_alpha PF08702.10 CCF37339.1 - 0.035 14.3 7.4 0.017 15.3 5.1 1.6 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Shugoshin_N PF07558.11 CCF37339.1 - 0.035 14.0 0.9 0.035 14.0 0.9 2.5 4 0 0 4 4 1 0 Shugoshin N-terminal coiled-coil region MPS2 PF17060.5 CCF37339.1 - 0.04 13.2 8.0 0.048 12.9 8.0 1.2 1 0 0 1 1 1 0 Monopolar spindle protein 2 JIP_LZII PF16471.5 CCF37339.1 - 0.042 14.0 8.3 4.2 7.6 0.3 3.5 2 1 1 3 3 3 0 JNK-interacting protein leucine zipper II HAP1_N PF04849.13 CCF37339.1 - 0.043 13.0 14.1 0.085 12.0 14.0 1.5 1 1 0 1 1 1 0 HAP1 N-terminal conserved region UPF0242 PF06785.11 CCF37339.1 - 0.059 13.5 14.1 0.14 12.2 13.7 1.8 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF4407 PF14362.6 CCF37339.1 - 0.06 12.7 13.0 0.094 12.1 13.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) NPV_P10 PF05531.12 CCF37339.1 - 0.061 13.8 3.1 0.25 11.9 0.2 2.6 3 0 0 3 3 2 0 Nucleopolyhedrovirus P10 protein Cut12 PF11500.8 CCF37339.1 - 0.068 13.1 8.6 1.3 9.0 8.2 2.5 1 1 0 1 1 1 0 Spindle pole body formation-associated protein PKcGMP_CC PF16808.5 CCF37339.1 - 0.069 13.0 11.9 0.94 9.4 0.3 4.4 5 0 0 5 5 4 0 Coiled-coil N-terminus of cGMP-dependent protein kinase NRBF2 PF08961.10 CCF37339.1 - 0.07 12.7 10.4 0.11 12.1 1.6 2.6 1 1 2 3 3 3 0 Nuclear receptor-binding factor 2, autophagy regulator DUF4200 PF13863.6 CCF37339.1 - 0.096 13.1 15.7 0.29 11.5 12.6 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) DUF5082 PF16888.5 CCF37339.1 - 0.1 12.9 10.3 1.9 8.8 6.7 3.3 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) HIP1_clath_bdg PF16515.5 CCF37339.1 - 0.12 13.0 15.8 0.64 10.7 7.1 2.7 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 HrpB7 PF09486.10 CCF37339.1 - 0.12 12.7 18.8 0.028 14.8 14.4 1.8 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) TSC22 PF01166.18 CCF37339.1 - 0.14 12.5 6.2 2.6 8.4 0.1 3.2 3 0 0 3 3 3 0 TSC-22/dip/bun family Golgin_A5 PF09787.9 CCF37339.1 - 0.18 11.3 14.2 0.15 11.5 12.4 1.6 1 1 1 2 2 2 0 Golgin subfamily A member 5 FAM76 PF16046.5 CCF37339.1 - 0.18 11.2 8.5 0.15 11.4 0.5 2.2 1 1 1 2 2 2 0 FAM76 protein DUF641 PF04859.12 CCF37339.1 - 0.18 12.1 12.0 0.84 10.0 5.4 2.3 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) Spc42p PF11544.8 CCF37339.1 - 0.19 11.7 3.4 0.42 10.6 0.5 2.5 1 1 1 2 2 2 0 Spindle pole body component Spc42p ADIP PF11559.8 CCF37339.1 - 0.2 11.8 15.6 0.4 10.8 2.4 2.7 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding TolA_bind_tri PF16331.5 CCF37339.1 - 0.23 11.6 20.4 0.43 10.7 4.1 3.1 2 1 1 3 3 3 0 TolA binding protein trimerisation APG6_N PF17675.1 CCF37339.1 - 0.26 11.8 16.6 1.1 9.8 4.8 2.1 1 1 1 2 2 2 0 Apg6 coiled-coil region BLOC1_2 PF10046.9 CCF37339.1 - 0.31 11.3 8.4 4.2 7.7 0.4 3.0 1 1 2 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 WDCP PF15390.6 CCF37339.1 - 0.67 8.3 6.2 0.87 7.9 6.2 1.2 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family GIT_CC PF16559.5 CCF37339.1 - 0.92 9.4 8.7 5.8 6.9 0.4 3.3 3 0 0 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor TMF_TATA_bd PF12325.8 CCF37339.1 - 1.3 9.3 16.3 1.2 9.3 11.3 2.8 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Sigma54_AID PF00309.20 CCF37339.1 - 1.6 8.7 9.1 0.31 10.9 0.5 2.9 3 0 0 3 3 3 0 Sigma-54 factor, Activator interacting domain (AID) GrpE PF01025.19 CCF37339.1 - 1.6 8.4 11.4 1.2 8.7 3.9 2.4 1 1 1 2 2 2 0 GrpE V_ATPase_I PF01496.19 CCF37339.1 - 1.7 6.5 8.8 2 6.3 8.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family MCC-bdg_PDZ PF10506.9 CCF37339.1 - 1.7 8.7 12.3 2.4 8.3 1.8 3.0 1 1 2 3 3 3 0 PDZ domain of MCC-2 bdg protein for Usher syndrome Exonuc_VII_L PF02601.15 CCF37339.1 - 2.1 7.9 11.9 2.9 7.4 11.9 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit SlyX PF04102.12 CCF37339.1 - 2.2 9.0 19.4 3.9 8.2 1.3 4.0 1 1 3 4 4 4 0 SlyX Uds1 PF15456.6 CCF37339.1 - 2.2 8.5 15.4 0.68 10.1 9.5 2.2 1 1 1 2 2 2 0 Up-regulated During Septation Prominin PF05478.11 CCF37339.1 - 2.3 6.1 5.5 2.4 6.0 5.5 1.1 1 0 0 1 1 1 0 Prominin I_LWEQ PF01608.17 CCF37339.1 - 2.5 8.3 12.0 13 6.0 11.9 2.0 1 1 0 1 1 1 0 I/LWEQ domain DUF4349 PF14257.6 CCF37339.1 - 2.8 7.3 17.6 3.3 7.1 3.1 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4349) TMPIT PF07851.13 CCF37339.1 - 3.4 6.8 7.7 2.3 7.4 5.6 1.6 1 1 1 2 2 2 0 TMPIT-like protein DivIC PF04977.15 CCF37339.1 - 4.9 7.0 18.0 6.2 6.7 0.5 4.0 2 1 2 4 4 4 0 Septum formation initiator CENP-H PF05837.12 CCF37339.1 - 5.2 7.5 17.2 1.6 9.2 10.4 2.4 1 1 1 2 2 2 0 Centromere protein H (CENP-H) YabA PF06156.13 CCF37339.1 - 5.5 7.7 12.0 2.8 8.6 3.1 3.0 1 1 2 3 3 3 0 Initiation control protein YabA Fmp27_WPPW PF10359.9 CCF37339.1 - 5.7 5.7 14.9 7 5.4 5.7 2.0 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain Myb_DNA-bind_6 PF13921.6 CCF37340.1 - 2.2e-14 53.4 0.2 9.2e-08 32.2 0.0 2.2 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 CCF37340.1 - 1.6e-12 47.4 0.1 4.1e-05 23.7 0.1 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain DUF4085 PF13315.6 CCF37340.1 - 0.16 11.6 0.1 0.22 11.2 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4085) Cyclin_N PF00134.23 CCF37342.1 - 5.2e-44 149.1 0.0 1.7e-43 147.4 0.0 1.8 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 CCF37342.1 - 1.3e-33 115.6 0.0 2e-33 115.0 0.0 1.3 1 0 0 1 1 1 1 Cyclin, C-terminal domain Polysacc_deac_1 PF01522.21 CCF37343.1 - 2.8e-27 95.1 0.0 5.1e-27 94.2 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase Chitin_bind_1 PF00187.19 CCF37343.1 - 6.7e-06 26.5 18.0 6.7e-06 26.5 18.0 2.0 2 0 0 2 2 2 1 Chitin recognition protein YonK PF09642.10 CCF37343.1 - 0.028 14.6 0.2 2.1 8.6 0.0 2.3 2 0 0 2 2 2 0 YonK protein DUF2334 PF10096.9 CCF37343.1 - 0.081 12.6 0.1 0.29 10.7 0.0 1.7 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2334) Defensin_int PF17858.1 CCF37343.1 - 3.3 7.8 7.1 10 6.2 4.0 2.8 2 1 1 3 3 3 0 Platypus intermediate defensin-like peptide PAP2 PF01569.21 CCF37344.1 - 1e-21 77.1 1.6 1e-21 77.1 1.6 2.5 2 1 0 2 2 2 1 PAP2 superfamily Myelin_PLP PF01275.19 CCF37344.1 - 0.057 13.3 0.0 11 5.8 0.1 2.4 2 0 0 2 2 2 0 Myelin proteolipid protein (PLP or lipophilin) MAP17 PF15807.5 CCF37344.1 - 0.42 10.8 1.1 0.82 9.9 1.1 1.4 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 CK_II_beta PF01214.18 CCF37345.1 - 4e-77 258.1 0.1 5e-77 257.8 0.1 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit Rhomboid_SP PF12595.8 CCF37345.1 - 0.14 11.5 0.0 0.22 10.8 0.0 1.2 1 0 0 1 1 1 0 Rhomboid serine protease Abhydrolase_6 PF12697.7 CCF37346.1 - 1.9e-15 58.1 0.7 2.2e-15 57.9 0.7 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.7 CCF37346.1 - 0.0038 17.0 0.1 0.0094 15.7 0.0 1.6 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_8 PF06259.12 CCF37346.1 - 0.0048 16.6 0.7 0.0076 15.9 0.7 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase Hydrolase_4 PF12146.8 CCF37346.1 - 0.0098 15.2 0.0 0.021 14.1 0.0 1.5 1 1 0 1 1 1 1 Serine aminopeptidase, S33 NPP1 PF05630.11 CCF37348.1 - 4e-67 226.1 0.0 4.6e-67 225.9 0.0 1.0 1 0 0 1 1 1 1 Necrosis inducing protein (NPP1) MFS_1 PF07690.16 CCF37349.1 - 3.3e-15 55.9 18.5 3.3e-15 55.9 18.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily UNC-93 PF05978.16 CCF37349.1 - 1.4e-07 31.3 2.2 1.4e-07 31.3 2.2 2.2 3 0 0 3 3 3 1 Ion channel regulatory protein UNC-93 TauD PF02668.16 CCF37350.1 - 7.7e-19 68.5 2.3 8.7e-18 65.1 2.3 2.0 1 1 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family CRIC_ras_sig PF10534.9 CCF37350.1 - 0.1 12.8 0.0 0.22 11.7 0.0 1.5 1 0 0 1 1 1 0 Connector enhancer of kinase suppressor of ras MFS_1 PF07690.16 CCF37351.1 - 6.2e-26 91.1 22.2 1.1e-25 90.4 22.2 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Gly-zipper_Omp PF13488.6 CCF37351.1 - 0.26 11.3 5.8 11 6.1 0.0 3.2 2 1 0 2 2 2 0 Glycine zipper Trehalose_recp PF06151.13 CCF37352.1 - 0.0016 17.1 0.8 0.0024 16.6 0.8 1.2 1 0 0 1 1 1 1 Trehalose receptor TPR_2 PF07719.17 CCF37353.1 - 1e-06 28.4 0.0 0.47 10.7 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 CCF37353.1 - 2.2e-05 24.6 0.3 0.001 19.3 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 CCF37353.1 - 2.7e-05 23.8 0.0 0.047 13.5 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 CCF37353.1 - 0.0011 19.6 0.2 0.099 13.3 0.8 3.2 2 1 0 2 2 2 1 Tetratricopeptide repeat DnaJ PF00226.31 CCF37353.1 - 0.014 15.5 0.0 0.03 14.5 0.0 1.5 1 0 0 1 1 1 0 DnaJ domain UQ_con PF00179.26 CCF37354.1 - 1.7e-50 170.3 0.0 1.9e-50 170.2 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 CCF37354.1 - 0.081 12.6 0.0 0.16 11.7 0.0 1.7 1 1 0 1 1 1 0 Prokaryotic E2 family B Glyco_hydro_3 PF00933.21 CCF37356.1 - 2.2e-62 211.3 0.0 3.3e-62 210.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.22 CCF37356.1 - 3e-52 177.5 0.0 5.9e-52 176.6 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 CCF37356.1 - 3.1e-23 81.7 0.3 7e-23 80.5 0.3 1.7 1 0 0 1 1 1 1 Fibronectin type III-like domain DUF11 PF01345.18 CCF37356.1 - 0.0097 16.2 0.1 0.029 14.7 0.1 1.9 1 0 0 1 1 1 1 Domain of unknown function DUF11 Hydrolase PF00702.26 CCF37357.1 - 0.00065 20.0 0.0 0.0018 18.6 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 CCF37357.1 - 0.0023 18.0 0.0 0.004 17.3 0.0 1.4 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase HAD PF12710.7 CCF37357.1 - 0.071 13.5 0.0 0.11 12.9 0.0 1.4 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Bmt2 PF11968.8 CCF37358.1 - 7.4e-82 274.5 0.0 9.7e-82 274.1 0.0 1.1 1 0 0 1 1 1 1 25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2 Methyltransf_23 PF13489.6 CCF37358.1 - 8e-05 22.5 0.0 0.0001 22.2 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain WW PF00397.26 CCF37359.1 - 1.2e-09 38.1 4.1 2.4e-09 37.1 4.1 1.5 1 0 0 1 1 1 1 WW domain TPR_10 PF13374.6 CCF37359.1 - 1.8 8.5 5.6 4.6 7.2 0.6 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat MFS_1 PF07690.16 CCF37360.1 - 6e-23 81.3 24.0 2e-22 79.6 24.0 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF37360.1 - 2.1e-14 53.2 6.3 2.7e-14 52.9 6.3 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter TRI12 PF06609.13 CCF37360.1 - 5.5e-05 21.8 2.6 8.2e-05 21.2 2.6 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) UNC-93 PF05978.16 CCF37360.1 - 0.27 10.9 4.7 0.034 13.9 0.7 1.5 2 0 0 2 2 2 0 Ion channel regulatory protein UNC-93 OATP PF03137.20 CCF37360.1 - 0.66 8.2 7.5 0.42 8.8 3.8 2.3 2 1 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family HTH_psq PF05225.16 CCF37361.1 - 2.5e-12 46.3 0.2 7.8e-12 44.7 0.1 1.9 2 0 0 2 2 2 1 helix-turn-helix, Psq domain HTH_23 PF13384.6 CCF37361.1 - 7.8e-05 22.4 0.1 0.00018 21.2 0.1 1.7 1 1 0 1 1 1 1 Homeodomain-like domain HTH_7 PF02796.15 CCF37361.1 - 0.00036 20.5 0.1 0.00069 19.6 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_30 PF13556.6 CCF37361.1 - 0.001 18.8 0.4 0.0022 17.7 0.1 1.8 2 0 0 2 2 2 1 PucR C-terminal helix-turn-helix domain HTH_28 PF13518.6 CCF37361.1 - 0.0031 17.6 0.1 0.0067 16.5 0.1 1.7 1 1 0 1 1 1 1 Helix-turn-helix domain HTH_1 PF00126.27 CCF37361.1 - 0.0042 17.0 1.3 0.025 14.5 0.3 2.4 2 1 1 3 3 3 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_Tnp_1 PF01527.20 CCF37361.1 - 0.0093 16.3 0.1 0.014 15.7 0.1 1.3 1 1 0 1 1 1 1 Transposase CENP-B_N PF04218.13 CCF37361.1 - 0.041 13.5 0.0 0.07 12.8 0.0 1.4 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain SpoIIID PF12116.8 CCF37361.1 - 0.07 13.2 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 Stage III sporulation protein D HTH_8 PF02954.19 CCF37361.1 - 0.075 12.8 1.6 1.3 8.9 0.0 3.1 2 2 1 3 3 3 0 Bacterial regulatory protein, Fis family OPT PF03169.15 CCF37362.1 - 2.8e-37 128.7 7.0 3.2e-37 128.5 7.0 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein ADH_zinc_N_2 PF13602.6 CCF37363.1 - 4.5e-13 50.4 0.0 8.9e-13 49.4 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 CCF37363.1 - 2.3e-12 47.0 0.1 3.9e-12 46.3 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCF37363.1 - 2.1e-06 27.5 0.1 7.4e-06 25.8 0.0 1.9 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain Epimerase PF01370.21 CCF37363.1 - 0.029 13.8 0.0 0.043 13.3 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family PEP-utilizers_C PF02896.18 CCF37363.1 - 0.19 10.8 0.0 0.28 10.3 0.0 1.2 1 0 0 1 1 1 0 PEP-utilising enzyme, TIM barrel domain Abhydrolase_1 PF00561.20 CCF37364.1 - 1.5e-09 37.9 0.0 7.7e-09 35.6 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Glyco_trans_1_2 PF13524.6 CCF37364.1 - 0.015 15.7 0.0 0.037 14.4 0.1 1.6 2 0 0 2 2 2 0 Glycosyl transferases group 1 Abhydrolase_8 PF06259.12 CCF37364.1 - 0.087 12.5 0.0 0.2 11.3 0.0 1.4 1 1 0 1 1 1 0 Alpha/beta hydrolase Metallophos PF00149.28 CCF37365.1 - 1.3e-32 114.0 0.0 3.6e-28 99.5 0.0 2.2 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase Glyco_hydro_65N PF03636.15 CCF37365.1 - 0.021 14.4 0.0 0.035 13.7 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain DUF866 PF05907.13 CCF37366.1 - 5.6e-67 224.5 0.1 6.2e-67 224.3 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF866) HalOD2 PF18547.1 CCF37366.1 - 0.056 13.4 0.6 0.79 9.7 0.0 2.2 2 0 0 2 2 2 0 Halobacterial output domain 2 Zn_ribbon_SprT PF17283.2 CCF37366.1 - 0.064 13.2 2.6 2.6 8.0 0.1 2.3 2 0 0 2 2 2 0 SprT-like zinc ribbon domain DUF4379 PF14311.6 CCF37366.1 - 0.54 10.7 4.4 0.21 12.0 1.2 2.0 1 1 1 2 2 2 0 Probable Zinc-ribbon domain Glyco_hydro_61 PF03443.14 CCF37367.1 - 3.5e-48 164.3 0.6 4.7e-48 163.9 0.0 1.5 2 0 0 2 2 2 1 Glycosyl hydrolase family 61 DUF963 PF06131.11 CCF37367.1 - 2.4 7.7 12.9 0.24 10.8 8.0 1.9 2 0 0 2 2 2 0 Schizosaccharomyces pombe repeat of unknown function (DUF963) p450 PF00067.22 CCF37368.1 - 9e-58 196.1 0.0 1.1e-57 195.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 O-FucT PF10250.9 CCF37369.1 - 5.3e-15 56.0 0.0 2.8e-14 53.6 0.0 2.1 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase HTH_Tnp_Tc5 PF03221.16 CCF37371.1 - 3.2e-13 49.5 0.3 1e-11 44.7 0.0 2.5 3 0 0 3 3 3 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 CCF37371.1 - 4.1e-09 36.0 0.0 7.1e-09 35.3 0.0 1.4 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_23 PF13384.6 CCF37371.1 - 0.0042 16.8 0.4 0.014 15.2 0.1 2.0 2 0 0 2 2 2 1 Homeodomain-like domain CENP-B_N PF04218.13 CCF37371.1 - 0.023 14.3 0.0 0.042 13.5 0.0 1.3 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HTH_28 PF13518.6 CCF37371.1 - 0.064 13.4 0.6 0.28 11.3 0.0 2.4 3 0 0 3 3 3 0 Helix-turn-helix domain G-patch PF01585.23 CCF37373.1 - 1e-15 57.3 2.1 2.3e-15 56.2 2.1 1.6 1 0 0 1 1 1 1 G-patch domain TIP_N PF12457.8 CCF37373.1 - 4.6e-12 46.2 16.1 4.6e-12 46.2 16.1 3.5 2 2 1 3 3 3 1 Tuftelin interacting protein N terminal G-patch_2 PF12656.7 CCF37373.1 - 8e-09 35.5 8.0 4.9e-08 32.9 1.5 3.8 2 2 2 4 4 4 1 G-patch domain FUSC PF04632.12 CCF37373.1 - 0.08 11.5 0.5 0.11 11.0 0.5 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family PEHE PF15275.6 CCF37373.1 - 0.1 13.2 2.4 0.3 11.7 2.4 1.8 1 0 0 1 1 1 0 PEHE domain Nop14 PF04147.12 CCF37373.1 - 1.5 7.0 25.6 0.54 8.4 7.1 2.2 2 0 0 2 2 2 0 Nop14-like family SpoIIIAH PF12685.7 CCF37373.1 - 2.7 7.8 8.6 4.7 7.0 2.8 2.2 2 0 0 2 2 2 0 SpoIIIAH-like protein Tim54 PF11711.8 CCF37373.1 - 6.7 5.4 10.9 0.13 11.0 2.0 2.0 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 Epimerase PF01370.21 CCF37374.1 - 1.5e-14 54.1 0.2 2.6e-14 53.3 0.2 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CCF37374.1 - 1.6e-11 43.7 0.0 3.2e-11 42.8 0.0 1.5 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 CCF37374.1 - 4.4e-10 39.8 0.0 6.1e-10 39.3 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 CCF37374.1 - 8.1e-10 38.3 0.0 7.3e-07 28.6 0.0 2.2 2 0 0 2 2 2 2 Male sterility protein NmrA PF05368.13 CCF37374.1 - 5.6e-09 35.9 0.1 9.3e-09 35.2 0.1 1.4 1 0 0 1 1 1 1 NmrA-like family GDP_Man_Dehyd PF16363.5 CCF37374.1 - 3.4e-08 33.3 0.1 1.1e-07 31.6 0.1 1.8 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 CCF37374.1 - 7.8e-05 22.0 0.0 0.00012 21.3 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 CCF37374.1 - 0.093 11.8 0.2 6.2 5.8 0.0 2.2 2 0 0 2 2 2 0 RmlD substrate binding domain FAD_binding_4 PF01565.23 CCF37375.1 - 2.7e-05 23.9 0.1 4.4e-05 23.2 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain DUF3176 PF11374.8 CCF37376.1 - 3.4e-30 104.4 3.9 7.8e-30 103.2 3.9 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3176) DoxX_2 PF13564.6 CCF37376.1 - 0.0066 16.5 4.0 0.0066 16.5 4.0 2.6 2 1 1 3 3 3 1 DoxX-like family Pex14_N PF04695.13 CCF37376.1 - 0.22 12.2 10.3 0.061 14.0 5.1 2.2 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region RTX PF02382.15 CCF37376.1 - 0.23 11.1 2.0 0.36 10.5 2.0 1.2 1 0 0 1 1 1 0 N-terminal domain in RTX protein SUIM_assoc PF16619.5 CCF37376.1 - 0.75 9.9 11.1 1.6 8.8 11.1 1.5 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CCF37376.1 - 3.1 7.3 8.3 4.7 6.7 8.3 1.2 1 0 0 1 1 1 0 Spt20 family Trypan_PARP PF05887.11 CCF37376.1 - 9.2 6.2 7.2 0.4 10.6 1.2 1.8 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) PIG-F PF06699.11 CCF37377.1 - 1.7e-63 214.1 3.0 2e-63 213.8 3.0 1.0 1 0 0 1 1 1 1 GPI biosynthesis protein family Pig-F PsbI PF02532.14 CCF37377.1 - 0.037 14.0 3.0 0.081 12.9 0.0 2.7 3 0 0 3 3 3 0 Photosystem II reaction centre I protein (PSII 4.8 kDa protein) Pmp3 PF01679.17 CCF37378.1 - 1.3e-24 86.2 7.5 1.4e-24 86.0 7.5 1.0 1 0 0 1 1 1 1 Proteolipid membrane potential modulator Zn_clus PF00172.18 CCF37379.1 - 1.4e-10 41.1 10.4 2.3e-10 40.4 10.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CCF37379.1 - 8.4e-07 28.3 2.6 3.9e-06 26.1 2.5 2.0 1 1 0 1 1 1 1 Fungal specific transcription factor domain DUF3544 PF12064.8 CCF37379.1 - 0.84 9.9 6.6 0.1 12.9 1.8 1.8 2 0 0 2 2 2 0 Protein kinase C-binding protein 1 Glyco_hydro_88 PF07470.13 CCF37380.1 - 7.5e-38 130.5 2.9 9.3e-38 130.2 2.9 1.0 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 MBOAT_2 PF13813.6 CCF37381.1 - 1.1e-16 60.8 7.5 2.1e-16 59.9 5.9 2.2 2 0 0 2 2 2 1 Membrane bound O-acyl transferase family Mak16 PF04874.14 CCF37382.1 - 4.9e-29 100.9 17.0 4.9e-29 100.9 17.0 2.5 2 0 0 2 2 2 1 Mak16 protein C-terminal region Ribosomal_L28e PF01778.17 CCF37382.1 - 3.2e-12 47.2 0.0 7.4e-12 46.0 0.0 1.6 1 0 0 1 1 1 1 Ribosomal L28e protein family TFIIF_alpha PF05793.12 CCF37382.1 - 3.6e-06 25.9 30.4 4.2e-06 25.6 30.4 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) BUD22 PF09073.10 CCF37382.1 - 1.5e-05 24.5 23.6 1.7e-05 24.3 23.6 1.0 1 0 0 1 1 1 1 BUD22 PPP4R2 PF09184.11 CCF37382.1 - 0.3 10.6 19.3 0.45 10.1 19.3 1.4 1 0 0 1 1 1 0 PPP4R2 PYC_OADA PF02436.18 CCF37382.1 - 0.54 10.0 3.7 0.58 9.9 2.8 1.6 1 1 0 1 1 1 0 Conserved carboxylase domain TFIIA PF03153.13 CCF37382.1 - 0.69 9.9 20.0 0.91 9.4 20.0 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Rgp1 PF08737.10 CCF37382.1 - 2.1 7.4 6.0 2.5 7.2 6.0 1.1 1 0 0 1 1 1 0 Rgp1 Nop14 PF04147.12 CCF37382.1 - 6.7 4.8 36.2 7.6 4.6 36.2 1.2 1 0 0 1 1 1 0 Nop14-like family Mso1_Sec1_bdg PF14475.6 CCF37383.1 - 5.4e-20 70.7 0.1 9.1e-20 70.0 0.1 1.3 1 0 0 1 1 1 1 Sec1-binding region of Mso1 PH_RBD PF12068.8 CCF37384.1 - 3.3e-08 33.2 0.0 4.9e-05 22.9 0.0 3.1 2 1 0 2 2 2 1 Rab-binding domain (RBD) PLA2_B PF01735.18 CCF37386.1 - 1.9e-83 280.5 0.2 5e-83 279.2 0.2 1.6 1 1 0 1 1 1 1 Lysophospholipase catalytic domain ketoacyl-synt PF00109.26 CCF37388.1 - 2.1e-69 234.0 0.0 4.7e-69 232.8 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 CCF37388.1 - 5e-38 129.7 0.1 1.3e-37 128.4 0.1 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Acyl_transf_1 PF00698.21 CCF37388.1 - 1.2e-25 90.7 0.2 1.9e-25 90.1 0.2 1.2 1 0 0 1 1 1 1 Acyl transferase domain KAsynt_C_assoc PF16197.5 CCF37388.1 - 6.1e-13 49.2 0.0 3.1e-12 46.9 0.0 2.2 1 1 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Thiolase_N PF00108.23 CCF37388.1 - 0.0021 17.5 0.1 0.021 14.2 0.1 2.1 2 0 0 2 2 2 1 Thiolase, N-terminal domain ACP_syn_III PF08545.10 CCF37388.1 - 0.031 14.1 1.0 0.35 10.8 1.0 2.5 1 1 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III SAT PF16073.5 CCF37388.1 - 0.11 12.3 0.2 0.51 10.0 0.0 2.1 2 0 0 2 2 2 0 Starter unit:ACP transacylase in aflatoxin biosynthesis Glyco_hydr_30_2 PF14587.6 CCF37389.1 - 2.1e-14 53.9 0.9 1.1e-13 51.6 0.5 2.2 2 0 0 2 2 2 1 O-Glycosyl hydrolase family 30 CTD PF12815.7 CCF37390.1 - 1.1e-22 80.4 34.6 2.2e-19 69.8 18.8 4.5 1 1 2 3 3 3 2 Spt5 C-terminal nonapeptide repeat binding Spt4 Cornifin PF02389.15 CCF37390.1 - 0.022 15.0 3.4 0.056 13.7 3.4 1.7 1 0 0 1 1 1 0 Cornifin (SPRR) family KOW PF00467.29 CCF37390.1 - 0.1 12.6 0.4 0.1 12.6 0.4 3.6 4 0 0 4 4 4 0 KOW motif Oxidored_molyb PF00174.19 CCF37391.1 - 8.2e-58 194.8 0.0 1.2e-57 194.3 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.16 CCF37391.1 - 1.5e-26 93.0 0.0 2.8e-26 92.2 0.0 1.4 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain Cyt-b5 PF00173.28 CCF37391.1 - 6.5e-12 45.4 0.1 1.1e-11 44.7 0.1 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain TAL_FSA PF00923.19 CCF37393.1 - 1.7e-33 116.3 0.0 2e-33 116.0 0.0 1.0 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase WbqC PF08889.11 CCF37393.1 - 0.001 19.1 0.0 0.0016 18.4 0.0 1.2 1 0 0 1 1 1 1 WbqC-like protein family NUDIX PF00293.28 CCF37394.1 - 8.2e-19 67.9 0.1 9.6e-19 67.7 0.1 1.1 1 0 0 1 1 1 1 NUDIX domain NUDIX_4 PF14815.6 CCF37394.1 - 0.027 14.5 0.0 0.036 14.0 0.0 1.2 1 0 0 1 1 1 0 NUDIX domain MFS_1 PF07690.16 CCF37395.1 - 3.9e-43 147.7 31.5 4.1e-41 141.1 11.5 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF37395.1 - 1.7e-07 30.5 4.0 1.7e-07 30.5 4.0 3.0 3 0 0 3 3 3 1 Sugar (and other) transporter BT1 PF03092.16 CCF37395.1 - 4.5 5.4 11.4 0.11 10.7 3.4 2.2 3 0 0 3 3 3 0 BT1 family Crust_neurohorm PF01147.17 CCF37396.1 - 0.011 15.6 2.5 0.016 15.1 2.5 1.2 1 0 0 1 1 1 0 Crustacean CHH/MIH/GIH neurohormone family SF3A2 PF16835.5 CCF37399.1 - 1.3e-34 118.4 0.1 2.2e-34 117.7 0.1 1.3 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) zf-met PF12874.7 CCF37399.1 - 3.4e-06 27.2 0.9 6.9e-06 26.3 0.9 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type CactinC_cactus PF09732.9 CCF37399.1 - 5.1e-05 23.2 0.2 7.4e-05 22.7 0.2 1.2 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein PRP4 PF08799.11 CCF37399.1 - 0.061 12.9 1.5 0.11 12.1 1.5 1.4 1 0 0 1 1 1 0 pre-mRNA processing factor 4 (PRP4) like MMS19_N PF14500.6 CCF37402.1 - 4.5e-61 206.7 0.2 1.2e-60 205.3 0.2 1.7 1 0 0 1 1 1 1 Dos2-interacting transcription regulator of RNA-Pol-II DCB PF16213.5 CCF37402.1 - 0.39 10.4 2.7 8.5 6.0 0.0 3.9 4 0 0 4 4 4 0 Dimerisation and cyclophilin-binding domain of Mon2 Sugar_tr PF00083.24 CCF37403.1 - 3.8e-10 39.2 0.4 9.9e-10 37.8 0.1 1.6 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF37403.1 - 0.00042 19.3 6.1 0.00066 18.7 6.1 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Epimerase PF01370.21 CCF37404.1 - 2.4e-14 53.4 0.2 9.8e-14 51.4 0.2 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CCF37404.1 - 9.5e-13 47.8 0.0 3.3e-12 46.0 0.0 1.7 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 CCF37404.1 - 1.4e-11 44.4 0.0 4.3e-10 39.5 0.0 2.7 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 CCF37404.1 - 1.2e-09 37.7 0.0 1.1e-07 31.3 0.0 2.1 2 0 0 2 2 2 2 Male sterility protein NAD_binding_10 PF13460.6 CCF37404.1 - 1.1e-05 25.5 0.0 2.8e-05 24.1 0.0 1.7 2 0 0 2 2 2 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 CCF37404.1 - 0.0011 18.2 0.0 0.0046 16.1 0.0 1.9 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein NmrA PF05368.13 CCF37404.1 - 0.058 12.9 0.0 0.088 12.4 0.0 1.4 1 0 0 1 1 1 0 NmrA-like family adh_short PF00106.25 CCF37404.1 - 0.19 11.2 0.0 2.4 7.6 0.0 2.2 2 0 0 2 2 2 0 short chain dehydrogenase Oxidored_FMN PF00724.20 CCF37405.1 - 1.4e-19 70.6 0.0 1.7e-19 70.3 0.0 1.2 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Fungal_trans PF04082.18 CCF37406.1 - 4e-18 65.4 0.0 7.1e-18 64.6 0.0 1.4 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF37406.1 - 5.9e-06 26.3 8.1 5.9e-06 26.3 8.1 2.0 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MDM1 PF15501.6 CCF37406.1 - 0.0036 16.5 1.3 0.0053 16.0 1.3 1.1 1 0 0 1 1 1 1 Nuclear protein MDM1 ABC_tran_CTD PF16326.5 CCF37406.1 - 0.37 11.1 3.2 0.21 11.8 0.5 2.0 2 0 0 2 2 2 0 ABC transporter C-terminal domain Miga PF10265.9 CCF37407.1 - 7.6 5.4 9.0 1 8.3 0.4 2.4 2 0 0 2 2 2 0 Mitoguardin BC10 PF06726.12 CCF37408.1 - 9e-18 64.3 11.4 1.5e-17 63.6 11.4 1.3 1 0 0 1 1 1 1 Bladder cancer-related protein BC10 ECM11 PF15463.6 CCF37409.1 - 2e-44 151.4 4.9 2e-44 151.4 4.9 1.6 2 0 0 2 2 2 1 Extracellular mutant protein 11 ApoC-I PF04691.12 CCF37409.1 - 0.38 10.7 3.5 0.18 11.7 0.7 1.9 2 0 0 2 2 2 0 Apolipoprotein C-I (ApoC-1) AAA_18 PF13238.6 CCF37410.1 - 1.8e-05 25.3 0.1 4e-05 24.2 0.0 1.6 2 0 0 2 2 1 1 AAA domain SRP54 PF00448.22 CCF37410.1 - 5.8e-05 22.8 0.0 8.9e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain MeaB PF03308.16 CCF37410.1 - 0.00011 21.3 0.0 0.00017 20.7 0.0 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB NACHT PF05729.12 CCF37410.1 - 0.0021 18.0 0.0 0.0039 17.1 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 CCF37410.1 - 0.0023 18.4 0.0 0.0037 17.7 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 CCF37410.1 - 0.0041 17.5 0.0 0.0067 16.9 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) CBP_BcsQ PF06564.12 CCF37410.1 - 0.0043 16.6 1.9 0.032 13.7 0.3 2.3 2 1 0 2 2 2 1 Cellulose biosynthesis protein BcsQ ArsA_ATPase PF02374.15 CCF37410.1 - 0.0043 16.3 0.2 0.0074 15.5 0.2 1.2 1 0 0 1 1 1 1 Anion-transporting ATPase NTPase_1 PF03266.15 CCF37410.1 - 0.0043 17.0 0.1 0.0067 16.3 0.1 1.3 1 0 0 1 1 1 1 NTPase AAA_14 PF13173.6 CCF37410.1 - 0.0068 16.4 0.0 0.014 15.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain KAP_NTPase PF07693.14 CCF37410.1 - 0.0069 15.7 0.0 0.012 14.9 0.0 1.3 1 0 0 1 1 1 1 KAP family P-loop domain AAA_30 PF13604.6 CCF37410.1 - 0.0084 15.8 0.0 0.015 15.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_31 PF13614.6 CCF37410.1 - 0.0089 16.0 0.2 0.015 15.2 0.2 1.3 1 0 0 1 1 1 1 AAA domain MobB PF03205.14 CCF37410.1 - 0.01 15.7 0.0 0.024 14.5 0.0 1.7 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Zeta_toxin PF06414.12 CCF37410.1 - 0.011 15.0 0.0 0.017 14.4 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin TsaE PF02367.17 CCF37410.1 - 0.011 15.7 0.0 0.022 14.7 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE CbiA PF01656.23 CCF37410.1 - 0.012 15.7 0.4 0.02 15.0 0.3 1.3 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Thymidylate_kin PF02223.17 CCF37410.1 - 0.015 15.0 0.1 0.026 14.2 0.1 1.4 1 0 0 1 1 1 0 Thymidylate kinase AAA_33 PF13671.6 CCF37410.1 - 0.018 15.2 0.0 0.033 14.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 CCF37410.1 - 0.02 14.6 0.0 0.036 13.8 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein APS_kinase PF01583.20 CCF37410.1 - 0.021 14.8 0.0 0.032 14.1 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase ATP_bind_1 PF03029.17 CCF37410.1 - 0.023 14.5 0.0 0.038 13.8 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein PRK PF00485.18 CCF37410.1 - 0.034 13.9 0.0 0.19 11.4 0.0 1.9 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family NB-ARC PF00931.22 CCF37410.1 - 0.044 13.0 0.4 0.099 11.8 0.1 1.6 2 0 0 2 2 2 0 NB-ARC domain AAA_5 PF07728.14 CCF37410.1 - 0.05 13.6 0.0 0.12 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_28 PF13521.6 CCF37410.1 - 0.05 13.8 0.0 0.095 12.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 CCF37410.1 - 0.073 12.8 0.0 0.13 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain 6PF2K PF01591.18 CCF37410.1 - 0.075 12.3 0.0 0.11 11.8 0.0 1.2 1 0 0 1 1 1 0 6-phosphofructo-2-kinase ABC_tran PF00005.27 CCF37410.1 - 0.087 13.3 0.9 0.18 12.3 0.2 1.9 2 1 0 2 2 2 0 ABC transporter adh_short PF00106.25 CCF37411.1 - 7.9e-86 286.5 9.7 1.1e-44 152.2 0.9 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCF37411.1 - 4e-67 226.2 4.9 1.6e-35 122.8 0.3 2.2 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF37411.1 - 3.3e-31 108.6 3.5 6.8e-15 55.4 0.1 2.2 2 0 0 2 2 2 2 KR domain THF_DHG_CYH_C PF02882.19 CCF37411.1 - 3.1e-05 23.3 1.4 0.0055 16.0 0.4 2.4 2 0 0 2 2 2 2 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Epimerase PF01370.21 CCF37411.1 - 0.0019 17.7 5.1 0.0096 15.4 0.1 2.8 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family FAM25 PF15825.5 CCF37411.1 - 0.076 13.4 7.6 1.2 9.5 1.1 2.5 2 0 0 2 2 2 0 FAM25 family Glucodextran_B PF09136.10 CCF37411.1 - 0.49 10.8 0.1 0.49 10.8 0.1 2.7 3 0 0 3 3 3 0 Glucodextranase, domain B 3HCDH_N PF02737.18 CCF37411.1 - 6.9 6.5 7.2 22 4.8 0.6 2.5 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Glyco_hydr_30_2 PF14587.6 CCF37412.1 - 7.4e-05 22.5 3.2 0.00015 21.5 3.2 1.5 1 1 0 1 1 1 1 O-Glycosyl hydrolase family 30 An_peroxidase PF03098.15 CCF37413.1 - 1.1e-32 113.3 0.1 8.3e-23 80.7 0.2 3.4 1 1 1 2 2 2 2 Animal haem peroxidase Peroxidase_2 PF01328.17 CCF37414.1 - 3.2e-40 138.7 0.0 3.9e-40 138.4 0.0 1.0 1 0 0 1 1 1 1 Peroxidase, family 2 Glycos_trans_3N PF02885.17 CCF37414.1 - 0.055 13.3 0.0 0.97 9.3 0.0 2.1 2 0 0 2 2 2 0 Glycosyl transferase family, helical bundle domain Goodbye PF17109.5 CCF37415.1 - 0.0061 17.0 0.4 9.3 6.7 0.0 4.5 3 2 0 3 3 3 2 fungal STAND N-terminal Goodbye domain Pex14_N PF04695.13 CCF37416.1 - 0.0051 17.5 0.2 0.0051 17.5 0.2 1.9 1 1 1 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region GATase_4 PF13230.6 CCF37417.1 - 1.5e-08 33.9 0.2 8.9e-07 28.1 0.1 2.6 2 1 0 2 2 2 2 Glutamine amidotransferases class-II GATase_6 PF13522.6 CCF37417.1 - 1.5e-06 28.5 0.0 2.4e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain Popeye PF04831.13 CCF37419.1 - 0.36 11.0 2.6 0.77 9.9 2.6 1.5 1 0 0 1 1 1 0 Popeye protein conserved region Fip1 PF05182.13 CCF37420.1 - 8.8e-21 73.1 1.5 1.7e-20 72.2 1.5 1.4 1 0 0 1 1 1 1 Fip1 motif Nucleoporin_FG PF13634.6 CCF37421.1 - 4.7e-24 85.1 159.1 7.7e-09 36.3 32.4 3.9 1 1 3 4 4 4 4 Nucleoporin FG repeat region TFIIA PF03153.13 CCF37421.1 - 0.005 16.9 17.7 0.0084 16.2 17.7 1.4 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Prominin PF05478.11 CCF37421.1 - 0.018 13.0 0.3 0.086 10.8 0.1 1.8 2 0 0 2 2 2 0 Prominin DUF1640 PF07798.11 CCF37421.1 - 0.041 13.9 0.4 0.15 12.1 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1640) SAM_Exu PF18609.1 CCF37421.1 - 0.074 13.2 0.0 0.19 11.8 0.0 1.7 1 0 0 1 1 1 0 Exuperantia SAM-like domain Tup_N PF08581.10 CCF37421.1 - 0.3 11.4 4.7 0.3 11.4 0.0 2.6 3 0 0 3 3 3 0 Tup N-terminal DUF812 PF05667.11 CCF37421.1 - 0.47 9.3 4.4 2.2 7.1 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF812) RNA_pol_3_Rpc31 PF11705.8 CCF37422.1 - 6.1e-06 26.7 19.5 8e-06 26.3 19.5 1.2 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 NTF2 PF02136.20 CCF37423.1 - 6.7e-25 88.0 0.2 1.1e-24 87.3 0.2 1.3 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain RRM_1 PF00076.22 CCF37423.1 - 1.5e-05 24.7 0.1 2.9e-05 23.8 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 CCF37423.1 - 0.05 13.7 0.0 0.15 12.1 0.0 1.8 1 0 0 1 1 1 0 RNA binding motif EHN PF06441.12 CCF37424.1 - 4e-10 40.0 0.0 7.3e-10 39.2 0.0 1.5 1 0 0 1 1 1 1 Epoxide hydrolase N terminus Nnf1 PF03980.14 CCF37425.1 - 7.2e-34 116.5 2.6 7.2e-34 116.5 2.6 2.4 3 1 1 4 4 4 1 Nnf1 DUF3135 PF11333.8 CCF37425.1 - 0.036 14.3 1.4 14 6.0 0.5 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF3135) DUF655 PF04919.12 CCF37425.1 - 0.072 13.0 0.0 0.1 12.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF655) GST_C_2 PF13410.6 CCF37425.1 - 0.18 11.9 1.0 0.58 10.2 1.0 1.9 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain DUF2203 PF09969.9 CCF37425.1 - 0.98 10.2 3.2 1 10.1 0.1 2.4 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2203) HAUS6_N PF14661.6 CCF37425.1 - 4.3 6.8 6.8 2.6 7.6 2.5 2.3 2 1 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus CCDC53 PF10152.9 CCF37425.1 - 9.5 6.6 19.9 6 7.3 14.3 2.6 2 2 0 2 2 2 0 Subunit CCDC53 of WASH complex PH_9 PF15410.6 CCF37426.1 - 4.3e-08 33.5 0.0 7e-08 32.9 0.0 1.2 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 CCF37426.1 - 0.0004 20.9 0.1 0.0007 20.1 0.1 1.4 1 0 0 1 1 1 1 PH domain DUF1682 PF07946.14 CCF37426.1 - 0.2 10.8 0.0 0.39 9.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Cellulase PF00150.18 CCF37428.1 - 2.5e-14 53.4 3.7 3.3e-14 53.0 3.7 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) UBA_e1_thiolCys PF10585.9 CCF37428.1 - 0.0037 17.2 0.0 0.0054 16.7 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site PS_Dcarbxylase PF02666.15 CCF37430.1 - 3.6e-49 167.0 0.0 5.1e-49 166.6 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase Cytochrom_B561 PF03188.16 CCF37431.1 - 0.1 12.7 7.9 0.21 11.7 7.9 1.5 1 0 0 1 1 1 0 Eukaryotic cytochrome b561 DUF4079 PF13301.6 CCF37431.1 - 0.12 12.5 12.0 1.5 9.0 1.8 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4079) MFS_2 PF13347.6 CCF37432.1 - 2.2e-11 43.0 4.6 2.2e-11 43.0 4.6 3.0 3 1 0 3 3 3 1 MFS/sugar transport protein RasGAP PF00616.19 CCF37432.1 - 0.14 11.8 0.1 0.25 11.0 0.1 1.3 1 0 0 1 1 1 0 GTPase-activator protein for Ras-like GTPase MAGI_u1 PF16663.5 CCF37432.1 - 0.25 11.5 3.6 1.1 9.3 0.3 2.7 2 0 0 2 2 2 0 Unstructured region on MAGI Na_H_Exchanger PF00999.21 CCF37433.1 - 2.6e-72 243.8 39.7 3.3e-72 243.4 39.7 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family PHO4 PF01384.20 CCF37433.1 - 0.0031 16.6 0.0 0.011 14.8 0.0 2.0 1 1 0 1 1 1 1 Phosphate transporter family PepSY_TM PF03929.16 CCF37433.1 - 0.8 9.3 5.0 2.3 7.8 5.0 1.8 1 1 0 1 1 1 0 PepSY-associated TM region CorA PF01544.18 CCF37434.1 - 4.7e-06 26.1 0.0 6.1e-06 25.8 0.0 1.1 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein SUR7 PF06687.12 CCF37434.1 - 0.012 15.2 0.5 0.015 14.9 0.5 1.1 1 0 0 1 1 1 0 SUR7/PalI family TMEM43 PF07787.12 CCF37434.1 - 0.015 14.7 0.3 0.018 14.4 0.3 1.2 1 0 0 1 1 1 0 Transmembrane protein 43 Rick_17kDa_Anti PF05433.15 CCF37438.1 - 3.3e-06 26.8 1.3 0.013 15.3 0.1 2.3 2 0 0 2 2 2 2 Glycine zipper 2TM domain Gly-zipper_Omp PF13488.6 CCF37438.1 - 0.004 17.1 0.4 1.2 9.2 0.0 2.2 2 0 0 2 2 2 2 Glycine zipper Amidohydro_1 PF01979.20 CCF37440.1 - 2.2e-77 260.7 0.7 4.4e-77 259.7 0.6 1.5 2 0 0 2 2 2 1 Amidohydrolase family Urease_alpha PF00449.20 CCF37440.1 - 2e-55 186.3 2.5 4.4e-55 185.2 2.5 1.6 1 0 0 1 1 1 1 Urease alpha-subunit, N-terminal domain Urease_beta PF00699.20 CCF37440.1 - 3.3e-40 136.1 0.7 7.3e-40 134.9 0.0 2.0 3 0 0 3 3 3 1 Urease beta subunit Urease_gamma PF00547.18 CCF37440.1 - 9.8e-37 125.2 0.0 2.4e-36 124.0 0.0 1.7 1 0 0 1 1 1 1 Urease, gamma subunit Amidohydro_3 PF07969.11 CCF37440.1 - 1.5e-10 41.2 0.4 1.2e-06 28.3 0.0 2.3 2 0 0 2 2 2 2 Amidohydrolase family Amidohydro_2 PF04909.14 CCF37440.1 - 0.0016 18.3 0.0 0.013 15.3 0.0 2.1 2 0 0 2 2 2 1 Amidohydrolase Glyco_hydro_72 PF03198.14 CCF37442.1 - 7.9e-118 393.3 3.8 9.8e-118 393.0 3.8 1.0 1 0 0 1 1 1 1 Glucanosyltransferase G-alpha PF00503.20 CCF37445.1 - 9.1e-117 390.2 0.7 1e-116 390.0 0.7 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 CCF37445.1 - 7.8e-16 58.0 0.2 5e-10 39.1 0.2 2.6 2 1 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 CCF37445.1 - 0.0018 17.6 4.0 0.096 12.0 0.1 2.5 1 1 1 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 CCF37445.1 - 0.0032 17.7 0.2 1.2 9.4 0.1 2.6 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 CCF37445.1 - 0.1 12.4 0.0 0.22 11.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF1776 PF08643.10 CCF37447.1 - 4.7e-105 351.2 0.0 5.7e-105 350.9 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) adh_short PF00106.25 CCF37447.1 - 0.022 14.2 0.0 0.093 12.2 0.0 1.9 2 0 0 2 2 2 0 short chain dehydrogenase Vps53_N PF04100.12 CCF37448.1 - 5.7e-98 328.4 0.4 9.8e-98 327.6 0.4 1.4 1 0 0 1 1 1 1 Vps53-like, N-terminal DUF2451 PF10474.9 CCF37448.1 - 0.00011 22.1 0.2 0.00035 20.4 0.2 1.8 1 1 1 2 2 2 1 Protein of unknown function C-terminus (DUF2451) RINT1_TIP1 PF04437.13 CCF37448.1 - 0.00026 20.0 0.9 0.039 12.8 0.0 3.0 3 0 0 3 3 3 1 RINT-1 / TIP-1 family Sec6 PF06046.13 CCF37448.1 - 0.0014 17.1 0.4 0.045 12.1 0.2 2.2 2 0 0 2 2 2 1 Exocyst complex component Sec6 VPS53_C PF16854.5 CCF37448.1 - 0.012 15.5 0.0 0.059 13.2 0.0 2.0 1 1 1 2 2 2 0 Vacuolar protein sorting-associated protein 53 C-terminus Vps54_N PF10475.9 CCF37448.1 - 0.04 13.2 5.4 0.085 12.1 5.4 1.5 1 0 0 1 1 1 0 Vacuolar-sorting protein 54, of GARP complex FliG_N PF14842.6 CCF37448.1 - 0.12 13.0 0.2 0.58 10.7 0.2 2.2 2 0 0 2 2 2 0 FliG N-terminal domain DUF5082 PF16888.5 CCF37448.1 - 0.2 11.9 0.9 0.46 10.8 0.4 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) Zw10 PF06248.13 CCF37448.1 - 0.21 10.1 2.3 0.41 9.1 2.3 1.4 1 0 0 1 1 1 0 Centromere/kinetochore Zw10 Spc7 PF08317.11 CCF37449.1 - 6.7e-128 425.9 6.8 1.1e-127 425.2 6.8 1.3 1 0 0 1 1 1 1 Spc7 kinetochore protein Spc7_N PF15402.6 CCF37449.1 - 1.4e-100 338.1 48.4 5.9e-88 296.2 24.9 3.5 2 1 2 4 4 4 3 N-terminus of kinetochore NMS complex subunit Spc7 Spc7_C2 PF15577.6 CCF37449.1 - 9.3e-24 83.3 0.1 1.8e-23 82.4 0.1 1.5 1 0 0 1 1 1 1 Spc7_C2 Lebercilin PF15619.6 CCF37449.1 - 0.016 14.9 10.2 0.042 13.5 10.2 1.7 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease Pox_A_type_inc PF04508.12 CCF37449.1 - 0.021 14.7 5.2 4 7.4 1.9 3.8 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat Exonuc_VII_L PF02601.15 CCF37449.1 - 0.025 14.2 3.1 0.053 13.1 3.1 1.5 1 0 0 1 1 1 0 Exonuclease VII, large subunit Erythro_esteras PF05139.14 CCF37449.1 - 0.081 12.7 1.4 0.19 11.5 1.4 1.6 1 0 0 1 1 1 0 Erythromycin esterase Peptidase_C50 PF03568.17 CCF37449.1 - 0.12 11.5 3.7 0.2 10.7 3.7 1.3 1 0 0 1 1 1 0 Peptidase family C50 MscS_porin PF12795.7 CCF37449.1 - 0.12 11.9 10.6 0.26 10.8 10.6 1.5 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain HemX PF04375.14 CCF37449.1 - 0.13 11.6 4.1 0.22 10.8 4.1 1.4 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Csm1_N PF18504.1 CCF37449.1 - 0.15 12.4 9.8 0.78 10.1 5.2 3.4 3 0 0 3 3 3 0 Csm1 N-terminal domain BLOC1_2 PF10046.9 CCF37449.1 - 0.17 12.2 6.0 0.34 11.2 4.6 2.3 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 PV-1 PF06637.11 CCF37449.1 - 0.2 10.5 8.0 0.32 9.8 8.0 1.2 1 0 0 1 1 1 0 PV-1 protein (PLVAP) Laminin_I PF06008.14 CCF37449.1 - 0.2 11.4 10.1 0.42 10.3 10.1 1.4 1 0 0 1 1 1 0 Laminin Domain I Baculo_PEP_C PF04513.12 CCF37449.1 - 0.2 11.7 0.1 0.39 10.8 0.1 1.4 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus COG2 PF06148.11 CCF37449.1 - 0.36 10.9 4.7 0.13 12.3 1.7 1.8 2 0 0 2 2 1 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF16 PF01519.16 CCF37449.1 - 0.42 11.1 5.1 1.2 9.7 4.7 2.0 1 1 0 1 1 1 0 Protein of unknown function DUF16 TPR_MLP1_2 PF07926.12 CCF37449.1 - 0.56 10.3 18.1 0.42 10.7 14.2 2.6 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein HMMR_N PF15905.5 CCF37449.1 - 0.58 9.6 16.1 0.047 13.2 10.8 1.8 2 0 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal SHE3 PF17078.5 CCF37449.1 - 0.62 9.7 12.4 0.027 14.2 6.4 1.7 2 0 0 2 2 2 0 SWI5-dependent HO expression protein 3 HrpB7 PF09486.10 CCF37449.1 - 0.69 10.3 13.9 2.4 8.5 13.4 1.9 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) FUSC PF04632.12 CCF37449.1 - 0.74 8.3 6.1 0.38 9.2 3.7 1.7 2 0 0 2 2 2 0 Fusaric acid resistance protein family Seryl_tRNA_N PF02403.22 CCF37449.1 - 0.91 9.8 7.8 3.1 8.1 7.8 1.9 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain kleA_kleC PF17383.2 CCF37449.1 - 1 9.7 5.8 3.2 8.1 5.8 1.9 1 0 0 1 1 1 0 Uncharacterized KorC regulated protein A Laminin_II PF06009.12 CCF37449.1 - 1 9.4 4.8 4.1 7.4 4.1 2.3 1 1 1 2 2 2 0 Laminin Domain II Mod_r PF07200.13 CCF37449.1 - 1.2 9.3 9.4 3.6 7.7 9.4 1.9 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein Atg14 PF10186.9 CCF37449.1 - 1.3 8.1 7.4 0.54 9.3 3.6 2.0 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 KASH_CCD PF14662.6 CCF37449.1 - 1.4 8.7 14.9 0.17 11.7 10.1 1.9 2 0 0 2 2 1 0 Coiled-coil region of CCDC155 or KASH KxDL PF10241.9 CCF37449.1 - 3.8 7.8 5.5 2.3 8.6 1.1 2.9 2 1 1 3 3 2 0 Uncharacterized conserved protein Cnn_1N PF07989.11 CCF37449.1 - 4.4 7.5 10.9 1.4 9.1 2.9 3.2 2 1 1 3 3 3 0 Centrosomin N-terminal motif 1 Prefoldin_2 PF01920.20 CCF37449.1 - 6.8 6.7 11.3 12 5.9 5.0 3.3 1 1 1 2 2 2 0 Prefoldin subunit DUF4407 PF14362.6 CCF37449.1 - 9 5.6 10.3 0.18 11.2 3.2 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) DUF2968 PF11180.8 CCF37449.1 - 9.3 5.8 9.6 17 5.0 9.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) Pkinase PF00069.25 CCF37450.1 - 1.7e-55 188.2 0.0 2.5e-55 187.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF37450.1 - 9.7e-43 146.3 0.0 1.5e-42 145.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF37450.1 - 0.0012 18.2 0.0 0.016 14.6 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 CCF37450.1 - 0.0087 14.9 0.0 0.056 12.2 0.0 2.0 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 CCF37450.1 - 0.013 15.4 0.0 0.061 13.2 0.0 2.0 1 1 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 CCF37450.1 - 0.042 13.2 0.0 0.086 12.2 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 CCF37450.1 - 0.065 12.2 0.0 1.4 7.8 0.0 2.1 2 0 0 2 2 2 0 Haspin like kinase domain Complex1_49kDa PF00346.19 CCF37452.1 - 5e-124 412.8 0.0 7.4e-124 412.2 0.0 1.3 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit NiFeSe_Hases PF00374.19 CCF37452.1 - 0.023 13.6 0.0 0.045 12.6 0.0 1.4 1 1 0 1 1 1 0 Nickel-dependent hydrogenase FAD_binding_3 PF01494.19 CCF37453.1 - 1.3e-25 90.5 0.0 1.3e-23 83.9 0.0 2.2 1 1 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.12 CCF37453.1 - 7.4e-06 25.2 0.2 0.00016 20.9 0.0 2.5 2 1 0 2 2 2 1 Lycopene cyclase protein DAO PF01266.24 CCF37453.1 - 6.1e-05 22.8 0.0 0.064 12.8 0.0 2.1 1 1 1 2 2 2 2 FAD dependent oxidoreductase SE PF08491.10 CCF37453.1 - 0.00023 20.3 0.0 0.00035 19.7 0.0 1.2 1 0 0 1 1 1 1 Squalene epoxidase Pyr_redox_2 PF07992.14 CCF37453.1 - 0.00086 18.6 0.0 0.007 15.6 0.0 2.0 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CCF37453.1 - 0.0032 17.5 0.0 0.007 16.4 0.0 1.6 1 0 0 1 1 1 1 FAD-NAD(P)-binding Thi4 PF01946.17 CCF37453.1 - 0.01 15.1 0.0 0.32 10.2 0.0 2.3 2 0 0 2 2 2 0 Thi4 family K_oxygenase PF13434.6 CCF37453.1 - 0.035 13.2 0.0 0.09 11.9 0.0 1.7 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 CCF37453.1 - 0.058 13.6 0.0 0.16 12.2 0.0 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain BamHI PF02923.15 CCF37453.1 - 0.084 12.6 0.0 0.2 11.4 0.0 1.6 1 0 0 1 1 1 0 Restriction endonuclease BamHI Trp_halogenase PF04820.14 CCF37453.1 - 0.085 11.7 0.0 2.1 7.1 0.0 2.5 3 0 0 3 3 3 0 Tryptophan halogenase HI0933_like PF03486.14 CCF37453.1 - 0.16 10.7 0.0 0.21 10.2 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein MSC PF09402.10 CCF37454.1 - 4.3e-115 384.8 0.0 5.7e-115 384.4 0.0 1.1 1 0 0 1 1 1 1 Man1-Src1p-C-terminal domain HeH PF12949.7 CCF37454.1 - 1e-16 60.3 0.1 2.3e-16 59.2 0.1 1.6 1 0 0 1 1 1 1 HeH/LEM domain Thymopoietin PF08198.11 CCF37454.1 - 0.064 12.9 0.0 0.15 11.7 0.0 1.5 1 0 0 1 1 1 0 Thymopoietin protein DUF2630 PF10944.8 CCF37454.1 - 0.17 12.4 0.9 3 8.4 0.1 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2630) Mt_ATP-synt_B PF05405.14 CCF37455.1 - 8.6e-53 178.3 2.8 1.1e-52 177.9 2.8 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) tRNA_anti-codon PF01336.25 CCF37455.1 - 0.097 12.7 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain Mcm10 PF09332.11 CCF37456.1 - 0.15 11.5 4.8 0.29 10.5 4.8 1.4 1 0 0 1 1 1 0 Mcm10 replication factor DUF3176 PF11374.8 CCF37457.1 - 1.8e-35 121.4 2.1 5.8e-35 119.7 2.1 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF3176) ADH_N PF08240.12 CCF37459.1 - 2.2e-11 43.6 0.0 2.5e-11 43.4 0.0 1.1 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain COesterase PF00135.28 CCF37461.1 - 9e-72 242.6 0.0 2.1e-71 241.3 0.0 1.4 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CCF37461.1 - 1.1e-06 28.6 0.0 6.5e-06 26.2 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CCF37461.1 - 0.024 14.1 0.0 0.038 13.5 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family Ribonuc_L-PSP PF01042.21 CCF37462.1 - 6.5e-39 132.7 0.0 7.6e-39 132.5 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP Clat_adaptor_s PF01217.20 CCF37463.1 - 2e-35 121.8 1.4 2.3e-35 121.6 1.4 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain PulA_N1 PF17999.1 CCF37463.1 - 0.013 16.2 0.2 0.021 15.6 0.2 1.4 1 1 0 1 1 1 0 Pullulanase N1-terminal domain Maf1 PF09174.10 CCF37465.1 - 2.2e-56 190.8 0.0 3.1e-56 190.3 0.0 1.2 1 0 0 1 1 1 1 Maf1 regulator CH PF00307.31 CCF37467.1 - 7.8e-47 158.0 0.1 1.5e-22 79.8 0.0 2.8 3 0 0 3 3 3 2 Calponin homology (CH) domain EFhand_Ca_insen PF08726.10 CCF37467.1 - 2.2e-23 82.1 0.4 1e-22 80.0 0.0 2.3 2 0 0 2 2 2 1 Ca2+ insensitive EF hand CAMSAP_CH PF11971.8 CCF37467.1 - 1.2e-10 41.0 0.1 4.7e-06 26.4 0.0 2.6 2 0 0 2 2 2 2 CAMSAP CH domain EF-hand_6 PF13405.6 CCF37467.1 - 0.00063 19.5 1.3 0.0029 17.4 0.1 2.8 3 0 0 3 3 3 1 EF-hand domain EF-hand_7 PF13499.6 CCF37467.1 - 0.0093 16.4 5.0 0.029 14.8 3.1 2.8 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.6 CCF37467.1 - 0.031 14.1 1.4 0.35 10.7 0.1 2.8 1 1 1 2 2 2 0 EF-hand domain pair DUF1088 PF06469.11 CCF37467.1 - 0.045 13.4 0.5 5.3 6.7 0.0 2.5 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1088) EF-hand_1 PF00036.32 CCF37467.1 - 0.058 13.0 0.2 0.71 9.6 0.0 2.6 2 0 0 2 2 2 0 EF hand Cytochrom_B562 PF07361.11 CCF37467.1 - 0.29 11.8 4.2 1.4 9.6 0.2 3.5 3 1 0 3 3 3 0 Cytochrome b562 Spectrin PF00435.21 CCF37467.1 - 0.32 11.5 3.7 21 5.7 1.6 2.8 2 0 0 2 2 2 0 Spectrin repeat PUF PF00806.19 CCF37468.1 - 1.1e-64 210.7 15.3 9.7e-09 34.5 0.1 8.3 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat SapB_2 PF03489.17 CCF37468.1 - 0.11 12.6 0.6 7.3 6.8 0.1 3.0 2 0 0 2 2 2 0 Saposin-like type B, region 2 DPBB_1 PF03330.18 CCF37469.1 - 0.00075 19.7 0.0 0.0015 18.8 0.0 1.5 1 0 0 1 1 1 1 Lytic transglycolase Barwin PF00967.17 CCF37469.1 - 0.0029 17.5 0.7 0.0077 16.1 0.3 1.7 1 1 1 2 2 2 1 Barwin family CorA PF01544.18 CCF37470.1 - 0.0014 18.0 0.0 0.0014 18.0 0.0 1.6 2 0 0 2 2 2 1 CorA-like Mg2+ transporter protein Trep_Strep PF09605.10 CCF37470.1 - 0.19 11.7 0.2 12 5.8 0.0 2.1 2 0 0 2 2 2 0 Hypothetical bacterial integral membrane protein (Trep_Strep) DUF3543 PF12063.8 CCF37471.1 - 9.1e-91 303.7 0.6 1.4e-90 303.0 0.6 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3543) Pkinase PF00069.25 CCF37471.1 - 5.6e-60 202.9 0.0 1.1e-59 201.9 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF37471.1 - 1.3e-42 145.8 0.0 2.4e-42 145.0 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase MIT PF04212.18 CCF37471.1 - 0.0027 17.7 0.1 0.26 11.4 0.1 2.6 2 0 0 2 2 2 1 MIT (microtubule interacting and transport) domain WD40 PF00400.32 CCF37472.1 - 1.6e-30 104.6 9.8 6.8e-07 29.9 0.5 6.1 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF37472.1 - 1.2e-08 35.1 0.1 0.12 12.7 0.0 4.8 3 2 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CCF37472.1 - 2e-05 23.4 5.7 0.02 13.5 0.3 4.6 3 2 2 5 5 5 2 Nucleoporin Nup120/160 DUF5082 PF16888.5 CCF37472.1 - 0.015 15.6 0.1 0.036 14.4 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) EzrA PF06160.12 CCF37472.1 - 0.06 11.5 1.6 0.1 10.7 1.6 1.3 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA ATG16 PF08614.11 CCF37472.1 - 0.063 13.5 2.6 0.12 12.6 2.6 1.4 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Cupin_8 PF13621.6 CCF37473.1 - 7.1e-31 107.8 0.0 1.1e-30 107.1 0.0 1.2 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 CCF37473.1 - 4.6e-09 36.2 0.0 3.2e-06 26.8 0.0 2.2 2 0 0 2 2 2 2 Cupin superfamily protein JmjC PF02373.22 CCF37473.1 - 0.00076 19.9 0.0 0.005 17.3 0.0 2.1 2 0 0 2 2 2 1 JmjC domain, hydroxylase Cupin_2 PF07883.11 CCF37473.1 - 0.026 14.2 0.0 0.055 13.2 0.0 1.4 1 0 0 1 1 1 0 Cupin domain CENP-C_C PF11699.8 CCF37474.1 - 2e-35 120.9 0.2 3.9e-35 119.9 0.2 1.5 1 0 0 1 1 1 1 Mif2/CENP-C like Mif2_N PF15624.6 CCF37474.1 - 8.4e-34 117.2 5.8 8.4e-34 117.2 5.8 3.6 2 1 0 2 2 2 1 Kinetochore CENP-C fungal homologue, Mif2, N-terminal Cupin_2 PF07883.11 CCF37474.1 - 7e-08 32.1 0.0 1.6e-07 30.9 0.0 1.6 1 0 0 1 1 1 1 Cupin domain Cupin_3 PF05899.12 CCF37474.1 - 0.0023 17.6 0.0 0.0068 16.1 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF861) Cupin_6 PF12852.7 CCF37474.1 - 0.024 14.4 0.0 0.06 13.1 0.0 1.7 1 0 0 1 1 1 0 Cupin Cupin_1 PF00190.22 CCF37474.1 - 0.025 14.2 0.1 0.048 13.3 0.1 1.4 1 0 0 1 1 1 0 Cupin RNase_HII PF01351.18 CCF37475.1 - 1.4e-48 165.4 0.0 1.7e-48 165.1 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease HII Adeno_VII PF03228.14 CCF37475.1 - 0.037 14.6 0.1 0.24 12.0 0.1 2.0 2 0 0 2 2 2 0 Adenoviral core protein VII SKG6 PF08693.10 CCF37476.1 - 0.095 12.1 0.5 0.14 11.6 0.5 1.3 1 0 0 1 1 1 0 Transmembrane alpha-helix domain BHD_2 PF10404.9 CCF37476.1 - 0.73 10.8 4.6 0.69 10.9 3.2 1.6 2 0 0 2 2 2 0 Rad4 beta-hairpin domain 2 NAD_binding_8 PF13450.6 CCF37477.1 - 6.6e-12 45.5 0.2 1.8e-11 44.1 0.2 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 CCF37477.1 - 2.1e-05 24.0 0.0 5.3e-05 22.7 0.0 1.6 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase FAD_oxidored PF12831.7 CCF37477.1 - 8.3e-05 22.1 0.0 0.00014 21.4 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CCF37477.1 - 0.00012 21.3 0.4 0.00017 20.8 0.4 1.2 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 CCF37477.1 - 0.00054 19.6 1.3 0.0014 18.3 0.5 2.0 3 0 0 3 3 3 1 FAD dependent oxidoreductase HI0933_like PF03486.14 CCF37477.1 - 0.00094 18.0 0.3 0.0017 17.1 0.3 1.4 1 0 0 1 1 1 1 HI0933-like protein Thi4 PF01946.17 CCF37477.1 - 0.0013 18.0 0.1 0.0023 17.2 0.1 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.14 CCF37477.1 - 0.0044 16.3 0.1 0.0089 15.3 0.1 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 CCF37477.1 - 0.017 14.0 0.3 0.11 11.3 0.2 1.9 2 0 0 2 2 2 0 Tryptophan halogenase Pyr_redox PF00070.27 CCF37477.1 - 0.037 14.6 0.1 0.15 12.7 0.0 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase GMC_oxred_N PF00732.19 CCF37477.1 - 0.06 12.7 0.0 0.1 12.0 0.0 1.3 1 0 0 1 1 1 0 GMC oxidoreductase GIDA PF01134.22 CCF37477.1 - 0.081 12.0 0.4 0.12 11.4 0.4 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A TrkA_N PF02254.18 CCF37477.1 - 0.085 13.1 0.5 0.26 11.5 0.1 1.9 2 0 0 2 2 2 0 TrkA-N domain Pyr_redox_3 PF13738.6 CCF37477.1 - 0.11 11.7 0.2 0.23 10.6 0.1 1.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Cupin_1 PF00190.22 CCF37479.1 - 2.8e-17 62.7 0.0 4.4e-17 62.1 0.0 1.2 1 0 0 1 1 1 1 Cupin Cupin_2 PF07883.11 CCF37479.1 - 0.0012 18.5 0.0 0.004 16.8 0.0 1.8 1 1 0 1 1 1 1 Cupin domain Glyco_hydro_47 PF01532.20 CCF37480.1 - 6.3e-166 552.8 0.1 7.4e-166 552.6 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 SKG6 PF08693.10 CCF37481.1 - 3.2e-06 26.4 1.9 8.2e-06 25.1 1.9 1.7 1 0 0 1 1 1 1 Transmembrane alpha-helix domain ATP-synt_I PF03899.15 CCF37481.1 - 0.034 14.5 0.2 0.2 12.0 0.0 2.1 2 0 0 2 2 2 0 ATP synthase I chain SMP PF04927.12 CCF37482.1 - 8.4e-05 23.0 3.2 0.00015 22.2 3.2 1.4 1 0 0 1 1 1 1 Seed maturation protein ZapB PF06005.12 CCF37483.1 - 1e-05 25.9 11.3 0.05 14.0 1.9 3.2 2 1 1 3 3 3 3 Cell division protein ZapB GAS PF13851.6 CCF37483.1 - 8.1e-05 22.1 12.5 0.00032 20.1 5.9 2.1 1 1 1 2 2 2 2 Growth-arrest specific micro-tubule binding APG6_N PF17675.1 CCF37483.1 - 0.00071 20.1 7.3 0.00071 20.1 7.3 2.1 1 1 1 2 2 2 1 Apg6 coiled-coil region KASH_CCD PF14662.6 CCF37483.1 - 0.0085 15.9 14.5 0.048 13.5 7.8 2.9 1 1 1 2 2 2 2 Coiled-coil region of CCDC155 or KASH DUF1664 PF07889.12 CCF37483.1 - 0.023 14.7 1.3 0.061 13.4 0.4 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) HrpB7 PF09486.10 CCF37483.1 - 0.067 13.6 8.8 0.23 11.8 1.8 2.4 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) Spectrin PF00435.21 CCF37483.1 - 0.079 13.5 2.9 0.093 13.2 1.4 1.8 1 1 0 1 1 1 0 Spectrin repeat Takusan PF04822.13 CCF37483.1 - 0.14 12.0 3.3 0.094 12.6 0.8 2.0 1 1 1 2 2 2 0 Takusan JIP_LZII PF16471.5 CCF37483.1 - 0.2 11.8 12.6 2 8.6 4.1 3.8 1 1 2 3 3 3 0 JNK-interacting protein leucine zipper II DUF4407 PF14362.6 CCF37483.1 - 0.21 10.9 4.3 0.31 10.4 4.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Laminin_II PF06009.12 CCF37483.1 - 0.21 11.6 2.3 0.36 10.9 2.3 1.4 1 0 0 1 1 1 0 Laminin Domain II TMF_TATA_bd PF12325.8 CCF37483.1 - 0.23 11.7 6.0 0.65 10.2 6.0 1.8 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding SKA2 PF16740.5 CCF37483.1 - 0.24 11.2 2.6 0.76 9.6 2.3 1.9 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 2 DUF4515 PF14988.6 CCF37483.1 - 0.24 11.2 13.8 0.24 11.2 1.7 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4515) YabA PF06156.13 CCF37483.1 - 0.26 12.0 11.4 4 8.1 0.7 3.2 1 1 2 3 3 3 0 Initiation control protein YabA ADIP PF11559.8 CCF37483.1 - 0.27 11.3 13.1 0.08 13.0 6.1 2.1 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding SOGA PF11365.8 CCF37483.1 - 0.33 12.1 9.9 0.52 11.5 3.9 2.6 2 1 0 2 2 2 0 Protein SOGA HIP1_clath_bdg PF16515.5 CCF37483.1 - 0.37 11.4 10.5 4.2 8.0 0.5 2.5 1 1 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Fungal_TACC PF12709.7 CCF37483.1 - 0.37 11.3 7.1 8.4 6.9 0.9 3.3 2 1 2 4 4 4 0 Fungal Transforming acidic coiled-coil (TACC) proteins HALZ PF02183.18 CCF37483.1 - 0.42 10.9 15.1 12 6.3 0.1 4.5 4 0 0 4 4 4 0 Homeobox associated leucine zipper bZIP_1 PF00170.21 CCF37483.1 - 0.49 10.5 12.9 26 5.0 0.1 4.4 1 1 4 5 5 5 0 bZIP transcription factor DUF3450 PF11932.8 CCF37483.1 - 0.89 8.8 6.8 2.3 7.5 1.6 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Spc7 PF08317.11 CCF37483.1 - 1 8.2 9.0 1.6 7.5 9.0 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein THOC7 PF05615.13 CCF37483.1 - 1.2 9.4 11.0 0.5 10.6 4.3 2.2 1 1 1 2 2 2 0 Tho complex subunit 7 Fez1 PF06818.15 CCF37483.1 - 5.6 7.4 11.8 21 5.5 11.8 1.8 1 1 0 1 1 1 0 Fez1 UPF0449 PF15136.6 CCF37483.1 - 7.4 7.1 10.1 0.48 10.9 1.2 3.0 1 1 2 3 3 3 0 Uncharacterised protein family UPF0449 TMF_DNA_bd PF12329.8 CCF37483.1 - 9.4 6.3 9.3 3.7 7.6 3.4 2.6 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding Elongin_A PF06881.11 CCF37484.1 - 9.7e-30 103.2 2.4 1.6e-29 102.5 2.4 1.3 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A TFIIF_beta_N PF17683.1 CCF37485.1 - 2.9e-32 112.2 0.4 7.2e-32 110.9 0.0 1.8 2 0 0 2 2 2 1 TFIIF, beta subunit N-terminus TFIIF_beta PF02270.15 CCF37485.1 - 2.9e-23 81.8 0.6 5.3e-23 80.9 0.6 1.4 1 0 0 1 1 1 1 TFIIF, beta subunit HTH domain HAD PF12710.7 CCF37486.1 - 6.9e-17 62.5 0.2 6.6e-16 59.3 0.2 2.4 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CCF37486.1 - 0.00037 20.9 0.0 0.00063 20.1 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 CCF37486.1 - 0.00081 19.5 0.0 0.0094 16.1 0.0 2.4 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.12 CCF37486.1 - 0.015 14.7 0.1 1 8.7 0.0 2.8 2 1 0 2 2 2 0 Putative Phosphatase Rsa3 PF14615.6 CCF37487.1 - 1.4e-21 75.7 0.4 1.9e-21 75.3 0.4 1.2 1 0 0 1 1 1 1 Ribosome-assembly protein 3 Ytp1 PF10355.9 CCF37488.1 - 2.1e-120 401.1 3.4 3e-120 400.6 3.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (Ytp1) DUF2427 PF10348.9 CCF37488.1 - 3.6e-31 107.1 7.1 3.6e-31 107.1 7.1 3.2 3 0 0 3 3 3 1 Domain of unknown function (DUF2427) Ca_hom_mod PF14798.6 CCF37488.1 - 0.12 11.4 1.9 0.14 11.3 0.1 1.9 2 0 0 2 2 2 0 Calcium homeostasis modulator DUF1700 PF08006.11 CCF37488.1 - 5 6.6 7.2 7.4 6.1 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1700) GFA PF04828.14 CCF37489.1 - 8.2e-22 77.4 0.9 8.2e-22 77.4 0.9 1.3 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme Ferric_reduct PF01794.19 CCF37490.1 - 2.5e-19 69.6 3.9 2.5e-19 69.6 3.9 2.3 4 0 0 4 4 4 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 CCF37490.1 - 9e-14 51.9 0.0 1.8e-12 47.7 0.0 2.3 1 1 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 CCF37490.1 - 4.4e-13 49.3 0.1 3.7e-12 46.3 0.0 2.3 2 0 0 2 2 2 1 FAD-binding domain NAD_binding_1 PF00175.21 CCF37490.1 - 0.00019 22.1 0.0 0.09 13.4 0.0 2.6 2 0 0 2 2 2 2 Oxidoreductase NAD-binding domain DUF4405 PF14358.6 CCF37490.1 - 0.42 11.2 7.4 0.064 13.8 0.8 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4405) DUF4153 PF13687.6 CCF37491.1 - 0.034 13.8 0.0 0.047 13.3 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4153) KilA-N PF04383.13 CCF37492.1 - 0.00072 19.4 0.0 0.011 15.6 0.0 2.4 1 1 0 1 1 1 1 KilA-N domain Med12 PF09497.10 CCF37493.1 - 0.14 12.5 0.0 4.3 7.7 0.0 2.6 1 1 1 2 2 2 0 Transcription mediator complex subunit Med12 p450 PF00067.22 CCF37496.1 - 1.1e-28 100.3 0.0 1.2e-28 100.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 MFS_1 PF07690.16 CCF37497.1 - 9.1e-36 123.5 49.0 9.1e-36 123.5 49.0 3.1 2 1 0 2 2 2 1 Major Facilitator Superfamily OATP PF03137.20 CCF37497.1 - 4.9e-05 21.8 0.1 0.00011 20.7 0.1 1.5 1 1 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family RasGAP PF00616.19 CCF37498.1 - 8.3e-51 172.6 0.0 2.7e-50 171.0 0.0 1.9 2 0 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.15 CCF37498.1 - 2.8e-49 166.8 2.3 2.8e-49 166.8 2.3 2.5 3 1 0 3 3 3 1 RasGAP C-terminus IQ PF00612.27 CCF37498.1 - 4.9e-07 29.0 6.9 0.053 13.3 0.2 5.8 5 0 0 5 5 5 4 IQ calmodulin-binding motif FixS PF03597.15 CCF37499.1 - 0.077 12.7 2.3 0.1 12.3 2.3 1.2 1 0 0 1 1 1 0 Cytochrome oxidase maturation protein cbb3-type HET PF06985.11 CCF37501.1 - 1.2e-19 71.1 0.0 3e-19 69.8 0.0 1.7 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Tannase PF07519.11 CCF37502.1 - 7.3e-07 28.4 1.7 1.4e-06 27.5 1.7 1.5 1 1 0 1 1 1 1 Tannase and feruloyl esterase Macoilin PF09726.9 CCF37503.1 - 1.3 7.5 26.3 2 6.9 26.3 1.2 1 0 0 1 1 1 0 Macoilin family Rox3 PF08633.10 CCF37504.1 - 6.5e-63 212.7 0.2 6.5e-63 212.7 0.2 1.4 2 0 0 2 2 2 1 Rox3 mediator complex subunit MCM PF00493.23 CCF37506.1 - 4.6e-106 352.9 0.2 3.4e-105 350.1 0.0 2.0 2 0 0 2 2 2 1 MCM P-loop domain MCM_OB PF17207.3 CCF37506.1 - 4.5e-36 123.5 0.1 8.3e-36 122.6 0.1 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 CCF37506.1 - 1.3e-27 96.0 1.4 3.3e-27 94.7 1.4 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 CCF37506.1 - 3.4e-15 56.5 1.0 8.7e-15 55.2 1.0 1.7 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 CCF37506.1 - 1.6e-06 27.7 0.0 0.00018 20.9 0.0 2.4 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 CCF37506.1 - 2.3e-05 24.4 0.0 4.9e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 CCF37506.1 - 0.00039 20.3 0.0 0.0017 18.2 0.0 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 CCF37506.1 - 0.06 13.1 0.0 1.2 8.8 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain Vps54 PF07928.12 CCF37507.1 - 1.1e-52 178.0 1.9 2.9e-52 176.7 0.0 2.7 4 0 0 4 4 4 1 Vps54-like protein Vps54_N PF10475.9 CCF37507.1 - 1e-05 25.0 0.7 1e-05 25.0 0.7 1.8 2 0 0 2 2 2 1 Vacuolar-sorting protein 54, of GARP complex DUF2451 PF10474.9 CCF37507.1 - 4.1e-05 23.5 0.0 0.00011 22.1 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function C-terminus (DUF2451) DUF5364 PF17322.2 CCF37507.1 - 0.022 15.1 0.5 0.072 13.4 0.5 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5364) FliJ PF02050.16 CCF37507.1 - 0.18 12.1 2.1 1.1 9.5 0.6 2.7 2 0 0 2 2 2 0 Flagellar FliJ protein Sec8_exocyst PF04048.14 CCF37507.1 - 0.5 10.3 2.6 0.75 9.7 0.2 2.5 3 0 0 3 3 3 0 Sec8 exocyst complex component specific domain COG2 PF06148.11 CCF37507.1 - 1.1 9.4 6.7 0.29 11.2 1.3 2.7 3 0 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 COG5 PF10392.9 CCF37507.1 - 1.5 9.0 5.1 11 6.2 1.2 3.0 2 0 0 2 2 2 0 Golgi transport complex subunit 5 CobS PF02654.15 CCF37513.1 - 0.028 14.6 0.2 0.038 14.2 0.2 1.2 1 0 0 1 1 1 0 Cobalamin-5-phosphate synthase Mucin PF01456.17 CCF37513.1 - 0.32 11.0 7.2 13 5.7 0.0 2.2 2 0 0 2 2 2 0 Mucin-like glycoprotein UPF0126 PF03458.13 CCF37515.1 - 0.014 15.3 1.8 0.017 15.0 1.8 1.1 1 0 0 1 1 1 0 UPF0126 domain Cytochrome-c551 PF10643.9 CCF37515.1 - 0.049 13.2 0.6 0.059 12.9 0.6 1.1 1 0 0 1 1 1 0 Photosystem P840 reaction-centre cytochrome c-551 4HBT_2 PF13279.6 CCF37517.1 - 1.6e-07 31.8 0.0 2.5e-07 31.2 0.0 1.4 1 0 0 1 1 1 1 Thioesterase-like superfamily adh_short PF00106.25 CCF37518.1 - 1.4e-14 54.1 0.1 1.6e-14 53.9 0.1 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF37518.1 - 7.2e-14 51.9 0.1 8.9e-14 51.6 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF37518.1 - 1.6e-06 28.1 0.0 1.7e-06 28.1 0.0 1.1 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 CCF37518.1 - 0.00038 19.7 0.0 0.00043 19.5 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Ldh_1_N PF00056.23 CCF37518.1 - 0.00071 19.7 0.1 0.00076 19.6 0.1 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 CCF37518.1 - 0.0023 17.8 0.0 0.0025 17.7 0.0 1.1 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Epimerase PF01370.21 CCF37518.1 - 0.0024 17.4 0.0 0.0026 17.2 0.0 1.0 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family ThiF PF00899.21 CCF37518.1 - 0.016 14.6 0.7 0.021 14.2 0.7 1.1 1 0 0 1 1 1 0 ThiF family THF_DHG_CYH_C PF02882.19 CCF37518.1 - 0.06 12.7 0.0 0.086 12.2 0.0 1.2 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 2-Hacid_dh_C PF02826.19 CCF37518.1 - 0.15 11.4 0.0 0.18 11.2 0.0 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GDP_Man_Dehyd PF16363.5 CCF37518.1 - 0.16 11.4 0.0 0.19 11.1 0.0 1.1 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase p450 PF00067.22 CCF37519.1 - 1.9e-23 83.0 0.0 4.4e-23 81.8 0.0 1.5 2 0 0 2 2 2 1 Cytochrome P450 p450 PF00067.22 CCF37520.1 - 9.5e-16 57.6 0.0 1.7e-15 56.7 0.0 1.4 1 0 0 1 1 1 1 Cytochrome P450 Asp PF00026.23 CCF37521.1 - 2e-28 99.7 0.0 2.4e-28 99.5 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_C PF14541.6 CCF37521.1 - 0.015 15.0 0.0 0.066 13.0 0.0 2.0 2 0 0 2 2 2 0 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.6 CCF37521.1 - 0.02 15.5 0.1 0.13 12.9 0.1 2.3 2 0 0 2 2 2 0 Aspartyl protease DUF3443 PF11925.8 CCF37521.1 - 0.033 13.1 0.0 3.7 6.3 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3443) gag-asp_proteas PF13975.6 CCF37521.1 - 0.047 14.2 0.0 0.51 10.9 0.0 2.3 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease TAXi_N PF14543.6 CCF37521.1 - 0.19 11.9 0.1 21 5.3 0.0 2.5 1 1 1 2 2 2 0 Xylanase inhibitor N-terminal Acyl_transf_1 PF00698.21 CCF37523.1 - 2.4e-68 231.0 0.2 3.3e-68 230.5 0.2 1.2 1 0 0 1 1 1 1 Acyl transferase domain PS-DH PF14765.6 CCF37523.1 - 3.5e-57 193.9 0.2 5.6e-57 193.2 0.2 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase KAsynt_C_assoc PF16197.5 CCF37523.1 - 3.1e-24 85.6 0.0 7.1e-24 84.4 0.0 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension ADH_N PF08240.12 CCF37523.1 - 6.5e-06 26.0 0.0 1.7e-05 24.6 0.0 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Methyltransf_11 PF08241.12 CCF37523.1 - 0.0086 16.7 0.0 0.073 13.7 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF37523.1 - 0.016 15.0 0.0 0.036 13.9 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 CCF37523.1 - 0.024 15.4 0.0 0.06 14.1 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain RNA_pol_Rpb1_1 PF04997.12 CCF37524.1 - 6.2e-107 357.5 0.1 7.6e-107 357.2 0.1 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 PF00623.20 CCF37524.1 - 1.2e-76 256.6 0.0 1.8e-76 256.0 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 CCF37524.1 - 1.5e-11 44.5 0.0 2.6e-11 43.7 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 WD40 PF00400.32 CCF37525.1 - 5.1e-15 55.6 8.2 2e-05 25.2 0.2 5.2 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF37525.1 - 1.3e-09 38.2 0.8 0.00024 21.4 0.0 5.0 2 2 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CCF37525.1 - 3.9e-05 23.6 0.6 0.036 13.9 0.0 3.1 3 1 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A Thg1 PF04446.12 CCF37526.1 - 3.5e-23 82.0 0.0 3.8e-23 81.9 0.0 1.0 1 0 0 1 1 1 1 tRNAHis guanylyltransferase PABP PF00658.18 CCF37528.1 - 2.4e-27 94.9 0.6 4.1e-27 94.2 0.6 1.3 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain AhpC-TSA_2 PF13911.6 CCF37530.1 - 3.7e-17 62.5 0.2 1.3e-16 60.7 0.0 1.9 3 0 0 3 3 3 1 AhpC/TSA antioxidant enzyme AhpC-TSA PF00578.21 CCF37530.1 - 0.005 16.7 0.0 0.014 15.3 0.0 1.7 1 1 0 1 1 1 1 AhpC/TSA family ParB_C PF18064.1 CCF37530.1 - 0.15 12.3 1.7 0.38 11.0 1.7 1.7 1 0 0 1 1 1 0 Centromere-binding protein ParB C-terminal SNARE_assoc PF09335.11 CCF37531.1 - 9.4e-20 71.3 8.9 2.1e-19 70.1 7.5 2.1 2 0 0 2 2 2 1 SNARE associated Golgi protein DUF1772 PF08592.11 CCF37531.1 - 0.0025 18.2 0.8 0.018 15.4 0.1 2.3 2 1 0 2 2 2 1 Domain of unknown function (DUF1772) Phage_holin_3_6 PF07332.11 CCF37531.1 - 0.065 13.3 9.1 0.35 10.9 2.0 2.7 2 1 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III DUF3278 PF11683.8 CCF37531.1 - 0.07 13.2 0.6 0.16 12.0 0.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3278) YrhC PF14143.6 CCF37531.1 - 0.17 12.0 2.3 0.29 11.3 0.7 2.3 2 1 0 2 2 2 0 YrhC-like protein Phage_holin_5_2 PF16079.5 CCF37531.1 - 1.3 9.5 0.1 1.3 9.5 0.1 3.0 3 0 0 3 3 3 0 Phage holin family Hol44, in holin superfamily V SieB PF14163.6 CCF37531.1 - 3.1 7.3 10.7 1.6 8.2 0.2 3.1 1 1 3 4 4 4 0 Super-infection exclusion protein B RACo_linker PF17650.1 CCF37532.1 - 0.022 14.6 0.0 0.046 13.6 0.0 1.5 1 0 0 1 1 1 0 RACo linker region DUF1729 PF08354.10 CCF37533.1 - 2.6e-139 464.1 0.0 4e-139 463.4 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) Acyl_transf_1 PF00698.21 CCF37533.1 - 4.2e-67 226.9 0.0 5.7e-67 226.5 0.0 1.2 1 0 0 1 1 1 1 Acyl transferase domain MaoC_dehydratas PF01575.19 CCF37533.1 - 1e-26 92.9 0.1 3e-26 91.4 0.0 1.8 2 0 0 2 2 2 1 MaoC like domain FAS_meander PF17951.1 CCF37533.1 - 3.6e-23 82.0 0.0 6.7e-23 81.1 0.0 1.4 1 0 0 1 1 1 1 Fatty acid synthase meander beta sheet domain MaoC_dehydrat_N PF13452.6 CCF37533.1 - 1.4e-06 28.5 0.0 4.6e-06 26.8 0.0 1.8 1 1 0 1 1 1 1 N-terminal half of MaoC dehydratase Lipoprotein_20 PF13942.6 CCF37533.1 - 0.079 12.9 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 YfhG lipoprotein GREB1 PF15782.5 CCF37534.1 - 1.1 6.3 6.8 1.3 6.1 6.8 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer FRG2 PF15315.6 CCF37535.1 - 0.11 12.7 6.8 0.25 11.5 6.8 1.5 1 0 0 1 1 1 0 Facioscapulohumeral muscular dystrophy candidate 2 MFS_1 PF07690.16 CCF37537.1 - 5.4e-36 124.3 37.9 5.4e-36 124.3 37.9 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF37537.1 - 2.9e-06 26.4 32.5 9.2e-06 24.8 5.5 2.9 3 0 0 3 3 3 2 Sugar (and other) transporter DuoxA PF10204.9 CCF37537.1 - 0.05 12.6 10.4 0.39 9.7 0.3 3.3 3 0 0 3 3 3 0 Dual oxidase maturation factor Methyltransf_23 PF13489.6 CCF37538.1 - 4.1e-08 33.2 0.0 5.3e-08 32.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF37538.1 - 0.00029 20.7 0.0 0.031 14.1 0.1 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_25 PF13649.6 CCF37538.1 - 0.0003 21.4 0.0 0.00068 20.3 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CCF37538.1 - 0.1 12.1 0.0 0.17 11.4 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_4 PF02390.17 CCF37538.1 - 0.14 11.7 0.0 0.27 10.7 0.0 1.5 1 0 0 1 1 1 0 Putative methyltransferase PH_10 PF15411.6 CCF37539.1 - 2.1e-41 141.0 0.3 4.6e-41 139.9 0.3 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain CDC24 PF06395.11 CCF37539.1 - 9.5e-33 112.3 0.0 2e-32 111.3 0.0 1.6 1 0 0 1 1 1 1 CDC24 Calponin RhoGEF PF00621.20 CCF37539.1 - 2.5e-29 102.8 0.1 4.2e-29 102.1 0.1 1.4 1 0 0 1 1 1 1 RhoGEF domain PB1 PF00564.24 CCF37539.1 - 1.9e-08 34.2 0.0 4.4e-08 32.9 0.0 1.7 1 0 0 1 1 1 1 PB1 domain CH PF00307.31 CCF37539.1 - 0.034 14.3 0.0 0.098 12.8 0.0 1.7 1 0 0 1 1 1 0 Calponin homology (CH) domain Mannosyl_trans3 PF11051.8 CCF37540.1 - 0.0048 16.3 0.0 0.0075 15.7 0.0 1.2 1 0 0 1 1 1 1 Mannosyltransferase putative Kelch_4 PF13418.6 CCF37541.1 - 3.3e-19 68.6 0.7 1.1e-08 35.0 0.0 5.0 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_5 PF13854.6 CCF37541.1 - 1.4e-18 66.5 2.0 0.0021 18.0 0.0 5.6 6 0 0 6 6 6 5 Kelch motif Kelch_3 PF13415.6 CCF37541.1 - 8e-15 54.7 4.0 1.6e-06 28.3 0.0 5.7 6 1 0 6 6 6 2 Galactose oxidase, central domain Kelch_2 PF07646.15 CCF37541.1 - 5.8e-08 32.4 2.2 0.0053 16.7 0.0 4.6 5 1 1 6 6 6 2 Kelch motif Kelch_6 PF13964.6 CCF37541.1 - 9.4e-08 32.1 0.3 0.52 10.7 0.0 4.4 4 1 1 5 5 5 3 Kelch motif Kelch_1 PF01344.25 CCF37541.1 - 8.8e-06 25.2 1.0 1.4 8.6 0.0 4.7 4 0 0 4 4 4 2 Kelch motif S10_plectin PF03501.15 CCF37542.1 - 0.15 12.1 0.0 0.18 11.9 0.0 1.2 1 0 0 1 1 1 0 Plectin/S10 domain Rieske PF00355.26 CCF37543.1 - 1.9e-10 40.5 0.0 3.4e-10 39.7 0.0 1.4 1 1 0 1 1 1 1 Rieske [2Fe-2S] domain UCR_TM PF02921.14 CCF37543.1 - 1.8e-09 37.9 2.8 2.9e-09 37.3 1.0 2.3 2 1 0 2 2 2 1 Ubiquinol cytochrome reductase transmembrane region CPSF_A PF03178.15 CCF37544.1 - 2.6e-49 168.3 0.0 2.9e-49 168.1 0.0 1.0 1 0 0 1 1 1 1 CPSF A subunit region Fungal_trans PF04082.18 CCF37545.1 - 1e-15 57.5 0.2 1.8e-15 56.7 0.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF37545.1 - 8.5e-06 25.8 7.0 1.8e-05 24.7 7.0 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Spt20 PF12090.8 CCF37545.1 - 2.1 7.9 10.5 4 7.0 10.5 1.4 1 0 0 1 1 1 0 Spt20 family Syntaxin PF00804.25 CCF37547.1 - 2.5e-17 63.2 14.7 3.2e-17 62.9 12.8 2.0 1 1 0 1 1 1 1 Syntaxin SNARE PF05739.19 CCF37547.1 - 7.6e-12 45.0 0.9 7.6e-12 45.0 0.9 2.5 3 0 0 3 3 3 1 SNARE domain DUF515 PF04415.12 CCF37547.1 - 0.014 13.9 1.1 0.019 13.4 0.6 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF515) Orf78 PF06024.12 CCF37547.1 - 0.015 15.6 0.4 0.044 14.1 0.2 1.8 1 1 0 1 1 1 0 Orf78 (ac78) LAP1C PF05609.12 CCF37547.1 - 0.037 13.1 11.9 0.092 11.8 11.9 1.6 1 1 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DUF2140 PF09911.9 CCF37547.1 - 0.046 13.3 0.1 0.11 12.1 0.1 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2140) OppC_N PF12911.7 CCF37547.1 - 0.069 13.1 0.1 0.13 12.2 0.1 1.4 1 0 0 1 1 1 0 N-terminal TM domain of oligopeptide transport permease C Chordopox_A33R PF05966.12 CCF37547.1 - 0.087 12.1 0.3 0.68 9.2 0.1 2.1 2 0 0 2 2 2 0 Chordopoxvirus A33R protein YajC PF02699.15 CCF37547.1 - 0.14 12.1 3.2 0.093 12.6 0.6 2.0 2 0 0 2 2 2 0 Preprotein translocase subunit V-SNARE PF05008.15 CCF37547.1 - 0.19 12.1 10.6 1.9 8.9 5.6 3.4 2 1 1 3 3 3 0 Vesicle transport v-SNARE protein N-terminus Mod_r PF07200.13 CCF37547.1 - 0.22 11.6 12.3 0.29 11.3 3.4 2.8 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Allexi_40kDa PF05549.11 CCF37547.1 - 0.37 10.3 6.1 0.44 10.0 0.3 2.2 2 0 0 2 2 2 0 Allexivirus 40kDa protein DUF4330 PF14221.6 CCF37547.1 - 0.4 10.9 5.5 0.55 10.4 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4330) DUF4083 PF13314.6 CCF37547.1 - 0.8 9.7 3.2 6.8 6.7 0.4 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4083) TMCO5 PF14992.6 CCF37547.1 - 0.97 9.0 7.7 45 3.5 7.7 2.1 1 1 0 1 1 1 0 TMCO5 family SKA1 PF07160.12 CCF37547.1 - 2.2 8.1 8.5 0.94 9.3 2.9 2.2 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 DUF2229 PF09989.9 CCF37547.1 - 3.4 7.3 6.0 2.5 7.7 1.9 2.1 1 1 1 2 2 2 0 CoA enzyme activase uncharacterised domain (DUF2229) Cytochrom_C_2 PF01322.20 CCF37547.1 - 6.2 7.7 8.0 22 6.0 0.8 3.0 1 1 0 2 2 2 0 Cytochrome C' EI24 PF07264.11 CCF37548.1 - 1.1e-17 64.9 1.6 1.9e-15 57.5 1.6 2.1 1 1 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) FmdA_AmdA PF03069.15 CCF37549.1 - 8.6e-72 242.0 0.0 9.6e-72 241.9 0.0 1.0 1 0 0 1 1 1 1 Acetamidase/Formamidase family SMP_LBD PF17047.5 CCF37550.1 - 1.5e-23 83.2 0.1 2e-23 82.8 0.1 1.2 1 0 0 1 1 1 1 Synaptotagmin-like mitochondrial-lipid-binding domain C2 PF00168.30 CCF37550.1 - 5.7e-19 68.3 0.0 2.9e-14 53.2 0.0 2.4 2 0 0 2 2 2 2 C2 domain HET PF06985.11 CCF37551.1 - 4.1e-35 121.3 0.0 8.8e-35 120.2 0.0 1.6 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Glyco_hydro_1 PF00232.18 CCF37552.1 - 1.6e-139 465.2 0.1 2e-139 464.9 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 p450 PF00067.22 CCF37553.1 - 5.3e-47 160.6 0.0 7.1e-47 160.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 BolA PF01722.18 CCF37554.1 - 3.4e-10 40.1 0.0 7.9e-10 38.9 0.0 1.5 1 1 0 1 1 1 1 BolA-like protein COesterase PF00135.28 CCF37555.1 - 7.5e-86 289.0 0.0 3.2e-85 287.0 0.0 1.7 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CCF37555.1 - 9.6e-05 22.3 0.1 0.00038 20.4 0.0 1.9 2 0 0 2 2 2 1 alpha/beta hydrolase fold HTH_psq PF05225.16 CCF37556.1 - 8e-11 41.5 0.0 1.6e-10 40.5 0.0 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.16 CCF37556.1 - 9.6e-09 35.2 0.0 2.2e-08 34.0 0.0 1.7 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_23 PF13384.6 CCF37556.1 - 0.0046 16.7 0.1 0.039 13.8 0.0 2.3 2 0 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.6 CCF37556.1 - 0.059 13.5 0.3 0.29 11.3 0.0 2.3 3 0 0 3 3 3 0 Helix-turn-helix domain DUF3328 PF11807.8 CCF37562.1 - 6.6e-50 169.9 0.6 8.6e-50 169.5 0.6 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) adh_short PF00106.25 CCF37563.1 - 5.9e-21 74.8 0.0 4.6e-17 62.1 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCF37563.1 - 2.4e-14 53.5 0.0 1.6e-13 50.8 0.0 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF37563.1 - 8.6e-06 25.8 0.0 1.4e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 KR domain CTP_synth_N PF06418.14 CCF37564.1 - 3.9e-88 295.2 0.1 5.4e-88 294.7 0.1 1.2 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.28 CCF37564.1 - 4.1e-51 173.5 0.0 6.1e-51 172.9 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 CCF37564.1 - 0.001 18.9 0.0 0.0028 17.5 0.0 1.8 1 1 0 1 1 1 1 Peptidase C26 TPP_enzyme_M_2 PF16582.5 CCF37564.1 - 0.015 15.0 0.0 0.029 14.1 0.0 1.4 1 0 0 1 1 1 0 Middle domain of thiamine pyrophosphate Ribonuc_red_lgC PF02867.15 CCF37565.1 - 1.2e-193 644.4 0.0 1.6e-193 644.0 0.0 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 CCF37565.1 - 6.7e-25 86.9 0.0 2.3e-23 82.0 0.0 2.5 2 0 0 2 2 2 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 CCF37565.1 - 4.4e-17 62.4 0.0 9e-17 61.4 0.0 1.6 1 0 0 1 1 1 1 ATP cone domain FAD_binding_3 PF01494.19 CCF37566.1 - 3.3e-09 36.4 2.2 2.6e-07 30.2 2.2 2.9 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 CCF37566.1 - 5.2e-05 23.4 0.0 0.00018 21.6 0.0 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CCF37566.1 - 0.0072 15.9 0.2 0.031 13.9 0.0 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCF37566.1 - 0.011 15.0 0.0 0.019 14.2 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCF37566.1 - 0.035 14.7 0.0 0.068 13.7 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCF37566.1 - 0.2 10.8 0.0 0.3 10.3 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Cg6151-P PF10233.9 CCF37567.1 - 8.5e-41 138.8 14.1 1e-40 138.6 14.1 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein CG6151-P QCR10 PF09796.9 CCF37567.1 - 0.22 11.6 1.4 16 5.6 0.1 2.6 2 0 0 2 2 2 0 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) Sugar_tr PF00083.24 CCF37568.1 - 4.8e-74 249.8 22.4 6e-74 249.5 22.4 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF37568.1 - 3.3e-16 59.2 22.8 3.3e-16 59.2 22.8 2.3 2 1 1 3 3 3 1 Major Facilitator Superfamily MFS_2 PF13347.6 CCF37568.1 - 4.6e-09 35.4 16.3 2.3e-05 23.1 4.3 2.4 2 1 0 2 2 2 2 MFS/sugar transport protein Abhydrolase_9_N PF15420.6 CCF37569.1 - 0.053 13.5 0.1 0.086 12.8 0.1 1.2 1 0 0 1 1 1 0 Alpha/beta-hydrolase family N-terminus fn3_5 PF06280.12 CCF37570.1 - 0.024 15.3 0.1 0.047 14.4 0.1 1.4 1 0 0 1 1 1 0 Fn3-like domain Glyco_hydro_88 PF07470.13 CCF37573.1 - 3.1e-09 36.4 0.4 9.1e-09 34.8 0.7 1.5 2 0 0 2 2 2 1 Glycosyl Hydrolase Family 88 MFS_1 PF07690.16 CCF37574.1 - 1.2e-23 83.6 24.7 1.2e-23 83.6 24.7 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF454 PF04304.13 CCF37574.1 - 0.023 14.7 0.4 0.023 14.7 0.4 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF454) Peptidase_M1 PF01433.20 CCF37575.1 - 2e-43 148.5 0.4 2.7e-43 148.1 0.4 1.2 1 0 0 1 1 1 1 Peptidase family M1 domain Leuk-A4-hydro_C PF09127.11 CCF37575.1 - 1.1e-37 128.5 0.0 2.8e-37 127.2 0.0 1.7 2 0 0 2 2 2 1 Leukotriene A4 hydrolase, C-terminal Peptidase_M1_N PF17900.1 CCF37575.1 - 1.8e-29 103.2 0.0 2.7e-29 102.7 0.0 1.2 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Svf1 PF08622.10 CCF37575.1 - 0.0077 16.3 0.0 0.048 13.7 0.0 2.0 2 0 0 2 2 2 1 Svf1-like N-terminal lipocalin domain TbpB_B_D PF01298.18 CCF37575.1 - 0.019 15.4 0.1 0.035 14.5 0.1 1.4 1 0 0 1 1 1 0 C-lobe and N-lobe beta barrels of Tf-binding protein B Peptidase_M61 PF05299.12 CCF37575.1 - 0.49 10.8 2.7 12 6.3 2.7 2.6 1 1 0 1 1 1 0 M61 glycyl aminopeptidase APG9 PF04109.16 CCF37576.1 - 3.5e-195 649.6 14.6 4e-195 649.4 14.6 1.0 1 0 0 1 1 1 1 Autophagy protein Apg9 DUF4413 PF14372.6 CCF37576.1 - 0.049 14.0 0.0 1.9 8.9 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4413) DUF3694 PF12473.8 CCF37577.1 - 8.2e-52 175.9 0.0 2e-51 174.7 0.0 1.7 1 0 0 1 1 1 1 Kinesin protein KIF1B PF12423.8 CCF37577.1 - 6.7e-07 29.7 0.2 6.7e-07 29.7 0.2 2.8 2 0 0 2 2 2 1 Kinesin protein 1B PH PF00169.29 CCF37577.1 - 0.0037 17.8 0.0 0.094 13.2 0.0 2.5 1 1 0 1 1 1 1 PH domain zf-C4H2 PF10146.9 CCF37577.1 - 0.096 13.0 6.0 0.25 11.6 6.0 1.7 1 0 0 1 1 1 0 Zinc finger-containing protein Exonuc_VII_L PF02601.15 CCF37577.1 - 0.78 9.2 9.1 1.4 8.4 9.1 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit OmpH PF03938.14 CCF37577.1 - 1.7 9.0 16.5 4.1 7.8 16.5 1.6 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Arm-DNA-bind_5 PF17293.2 CCF37577.1 - 3.6 8.1 5.6 22 5.5 5.6 2.4 1 1 0 1 1 1 0 Arm DNA-binding domain DUF1664 PF07889.12 CCF37577.1 - 4.1 7.5 10.0 11 6.1 9.5 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Vir_act_alpha_C PF10400.9 CCF37577.1 - 5.3 7.8 10.0 3.9 8.2 1.2 2.8 1 1 1 2 2 2 0 Virulence activator alpha C-term Cyt-b5 PF00173.28 CCF37578.1 - 2.8e-22 78.7 0.1 3.1e-22 78.5 0.1 1.0 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain YqzH PF14164.6 CCF37578.1 - 0.0068 16.4 0.8 0.043 13.9 0.1 2.2 2 1 1 3 3 3 1 YqzH-like protein BRX PF08381.11 CCF37578.1 - 0.02 14.2 0.8 0.11 11.9 0.8 2.0 1 1 0 1 1 1 0 Transcription factor regulating root and shoot growth via Pin3 DUF3328 PF11807.8 CCF37580.1 - 9.9e-20 71.3 0.1 1.3e-19 70.9 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) FixS PF03597.15 CCF37580.1 - 6.9 6.5 5.8 18 5.1 5.8 1.7 1 0 0 1 1 1 0 Cytochrome oxidase maturation protein cbb3-type Myb_DNA-binding PF00249.31 CCF37581.1 - 1.3e-31 108.5 11.3 1.7e-12 47.3 0.2 3.3 3 0 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CCF37581.1 - 1.1e-24 86.4 10.3 1.3e-12 47.8 0.7 3.4 1 1 2 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 CCF37581.1 - 1.5e-06 28.0 0.1 0.011 15.6 0.0 2.6 2 0 0 2 2 2 2 Myb DNA-binding like SLIDE PF09111.10 CCF37581.1 - 4.1e-05 23.6 0.0 0.1 12.6 0.0 3.3 1 1 2 3 3 3 1 SLIDE Myb_DNA-bind_2 PF08914.11 CCF37581.1 - 0.0053 16.9 2.6 0.31 11.2 0.1 3.4 3 1 1 4 4 3 1 Rap1 Myb domain SANT_DAMP1_like PF16282.5 CCF37581.1 - 0.0075 16.4 0.3 0.3 11.3 0.0 2.6 2 1 1 3 3 3 1 SANT/Myb-like domain of DAMP1 Fe_bilin_red PF05996.12 CCF37581.1 - 0.042 13.5 0.1 0.065 12.9 0.1 1.2 1 0 0 1 1 1 0 Ferredoxin-dependent bilin reductase DHR-2 PF06920.13 CCF37581.1 - 0.11 11.1 0.1 0.13 10.8 0.1 1.1 1 0 0 1 1 1 0 Dock homology region 2 Cwf_Cwc_15 PF04889.12 CCF37581.1 - 0.21 11.3 10.7 0.47 10.2 10.7 1.5 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF3246 PF11596.8 CCF37581.1 - 0.55 9.6 11.1 0.58 9.5 9.7 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3246) NOA36 PF06524.12 CCF37581.1 - 0.65 9.3 10.0 1 8.6 10.0 1.3 1 0 0 1 1 1 0 NOA36 protein DNA_pol_phi PF04931.13 CCF37581.1 - 1.7 6.6 8.1 2.3 6.2 8.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi CENP-B_dimeris PF09026.10 CCF37581.1 - 8.4 6.9 13.5 17 5.9 13.5 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain NEXCaM_BD PF16644.5 CCF37582.1 - 0.035 14.4 2.0 0.058 13.7 2.0 1.3 1 0 0 1 1 1 0 Regulatory region of Na+/H+ exchanger NHE binds to calmodulin Xpo1 PF08389.12 CCF37584.1 - 2.2e-36 125.2 0.3 4.1e-36 124.3 0.3 1.4 1 0 0 1 1 1 1 Exportin 1-like protein TetR_C_3 PF08362.11 CCF37584.1 - 0.054 13.4 0.0 0.46 10.4 0.0 2.0 2 0 0 2 2 2 0 YcdC-like protein, C-terminal region DUF2347 PF09804.9 CCF37586.1 - 1e-109 366.5 0.0 1.3e-109 366.2 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2347) DUF4484 PF14831.6 CCF37586.1 - 7.2e-65 219.0 0.0 1.3e-64 218.1 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4484) SPA PF08616.10 CCF37586.1 - 0.00016 21.6 0.0 0.00035 20.5 0.0 1.5 1 1 0 1 1 1 1 Stabilization of polarity axis Avl9 PF09794.9 CCF37586.1 - 0.0017 17.2 0.0 0.011 14.4 0.0 2.1 2 0 0 2 2 2 1 Transport protein Avl9 CENP-B_dimeris PF09026.10 CCF37586.1 - 0.0077 16.6 6.5 0.0077 16.6 6.5 1.9 2 0 0 2 2 2 1 Centromere protein B dimerisation domain Importin_rep_4 PF18808.1 CCF37586.1 - 0.027 14.7 1.3 0.049 13.9 0.5 1.8 2 0 0 2 2 1 0 Importin repeat Nro1 PF12753.7 CCF37586.1 - 0.11 11.4 0.6 0.18 10.7 0.6 1.3 1 0 0 1 1 1 0 Nuclear pore complex subunit Nro1 DUF3727 PF12527.8 CCF37586.1 - 0.13 12.5 1.7 0.29 11.4 1.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3727) NOA36 PF06524.12 CCF37586.1 - 0.49 9.7 3.7 0.78 9.0 3.7 1.2 1 0 0 1 1 1 0 NOA36 protein DUF4611 PF15387.6 CCF37586.1 - 3.4 7.9 8.2 2.4 8.4 2.0 3.6 5 0 0 5 5 5 0 Domain of unknown function (DUF4611) PBP1_TM PF14812.6 CCF37586.1 - 4.8 7.6 6.4 13 6.2 6.4 1.7 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal AOX PF01786.17 CCF37588.1 - 6.9e-79 264.4 0.0 7.4e-79 264.3 0.0 1.0 1 0 0 1 1 1 1 Alternative oxidase Zip PF02535.22 CCF37589.1 - 7.2e-59 199.7 7.9 9.3e-59 199.3 7.9 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter Ribosomal_S19e PF01090.19 CCF37590.1 - 8.4e-60 200.4 0.1 9.5e-60 200.2 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e DUF3648 PF12364.8 CCF37591.1 - 0.14 12.4 0.0 0.23 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3648) Peptidase_S41 PF03572.18 CCF37593.1 - 5.8e-07 29.2 0.0 1.1e-06 28.3 0.0 1.5 1 0 0 1 1 1 1 Peptidase family S41 FAD_binding_4 PF01565.23 CCF37595.1 - 4.2e-24 84.9 3.1 7.2e-24 84.1 3.1 1.4 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 CCF37595.1 - 0.044 13.9 0.0 0.093 12.9 0.0 1.5 1 0 0 1 1 1 0 Berberine and berberine like Glyco_trans_2_3 PF13632.6 CCF37597.1 - 4.7e-51 173.5 5.3 4.7e-51 173.5 5.3 2.0 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 CCF37597.1 - 2.2e-06 27.6 0.0 6.2e-06 26.1 0.0 1.8 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 CCF37597.1 - 0.0016 17.9 0.0 0.0035 16.8 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 21 p450 PF00067.22 CCF37598.1 - 7.4e-45 153.5 0.0 1.9e-44 152.2 0.0 1.5 1 1 0 1 1 1 1 Cytochrome P450 VWA_2 PF13519.6 CCF37598.1 - 0.11 13.1 0.1 0.47 11.1 0.0 2.0 2 0 0 2 2 2 0 von Willebrand factor type A domain adh_short PF00106.25 CCF37599.1 - 2.3e-21 76.2 0.0 3.2e-21 75.7 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF37599.1 - 1.4e-17 64.1 0.0 2e-17 63.5 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NmrA PF05368.13 CCF37599.1 - 0.0022 17.6 0.1 0.0037 16.9 0.1 1.3 1 0 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 CCF37599.1 - 0.0092 15.5 0.0 1.8 8.0 0.0 2.2 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CCF37599.1 - 0.033 14.1 0.5 0.097 12.5 0.5 1.8 1 1 0 1 1 1 0 NAD(P)H-binding DUF711 PF05167.12 CCF37599.1 - 0.038 12.9 0.0 0.043 12.7 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised ACR (DUF711) Aldedh PF00171.22 CCF37600.1 - 2.6e-14 52.6 11.5 3.4e-09 35.8 7.4 2.9 1 1 0 2 2 2 2 Aldehyde dehydrogenase family DUF2190 PF09956.9 CCF37600.1 - 0.032 14.7 1.4 0.29 11.7 0.3 2.8 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2190) URO-D PF01208.17 CCF37600.1 - 0.039 13.1 0.0 0.063 12.4 0.0 1.2 1 0 0 1 1 1 0 Uroporphyrinogen decarboxylase (URO-D) RNase_PH PF01138.21 CCF37603.1 - 1.7e-36 125.7 0.1 2.5e-36 125.1 0.1 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 Thioredoxin PF00085.20 CCF37604.1 - 3.8e-35 120.0 0.0 2e-27 95.2 0.0 2.6 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_6 PF13848.6 CCF37604.1 - 2.5e-12 47.1 0.0 0.00012 22.0 0.0 3.2 2 1 1 3 3 3 2 Thioredoxin-like domain Thioredoxin_2 PF13098.6 CCF37604.1 - 5.3e-08 33.3 0.6 0.0045 17.4 0.1 2.9 2 1 1 3 3 3 2 Thioredoxin-like domain OST3_OST6 PF04756.13 CCF37604.1 - 1.1e-07 31.5 0.0 1.3e-06 28.0 0.0 2.1 2 0 0 2 2 2 1 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 CCF37604.1 - 9.7e-05 22.6 0.1 2 8.8 0.0 4.4 3 2 1 4 4 4 1 Thioredoxin-like ERp29_N PF07912.13 CCF37604.1 - 0.00015 21.9 0.0 0.76 9.9 0.0 2.4 1 1 1 2 2 2 2 ERp29, N-terminal domain AhpC-TSA PF00578.21 CCF37604.1 - 0.00034 20.5 0.1 0.69 9.8 0.0 2.5 2 0 0 2 2 2 2 AhpC/TSA family Thioredoxin_7 PF13899.6 CCF37604.1 - 0.0025 18.0 0.0 0.0052 16.9 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like HyaE PF07449.11 CCF37604.1 - 0.0073 16.3 0.0 9.2 6.3 0.0 3.2 2 1 0 2 2 2 1 Hydrogenase-1 expression protein HyaE Thioredoxin_3 PF13192.6 CCF37604.1 - 0.012 15.6 0.0 0.8 9.8 0.0 2.6 2 0 0 2 2 2 0 Thioredoxin domain TraF PF13728.6 CCF37604.1 - 0.065 13.1 0.0 0.065 13.1 0.0 4.2 4 1 0 4 4 3 0 F plasmid transfer operon protein QSOX_Trx1 PF18108.1 CCF37604.1 - 0.068 13.3 0.0 0.19 11.9 0.0 1.7 1 0 0 1 1 1 0 QSOX Trx-like domain Calsequestrin PF01216.17 CCF37604.1 - 0.12 11.4 0.0 0.62 9.0 0.0 2.1 2 1 0 2 2 2 0 Calsequestrin CCDC53 PF10152.9 CCF37604.1 - 0.13 12.7 6.0 1.8 8.9 1.0 2.3 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex Cellulase PF00150.18 CCF37606.1 - 4.3e-20 72.3 0.2 8.2e-20 71.4 0.2 1.4 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) DUF4350 PF14258.6 CCF37606.1 - 0.11 13.0 0.0 2.2 8.8 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4350) zf-CCCH_4 PF18044.1 CCF37607.1 - 3.8e-09 36.1 3.6 6.3e-09 35.4 3.6 1.4 1 0 0 1 1 1 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 CCF37607.1 - 5.2e-07 29.5 7.7 8.4e-07 28.8 7.7 1.4 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH PF00642.24 CCF37607.1 - 5.8e-06 26.1 3.2 1e-05 25.3 3.2 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 CCF37607.1 - 0.015 16.0 0.7 0.015 16.0 0.7 1.5 2 0 0 2 2 2 0 Torus domain zf-CCCH_2 PF14608.6 CCF37607.1 - 0.15 12.5 4.4 0.33 11.5 4.4 1.6 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger Dimerisation PF08100.11 CCF37608.1 - 0.14 12.2 0.0 0.22 11.6 0.0 1.3 1 0 0 1 1 1 0 Dimerisation domain SBF PF01758.16 CCF37609.1 - 4e-50 170.2 10.4 4e-50 170.2 10.4 2.1 2 1 0 2 2 2 1 Sodium Bile acid symporter family Fungal_trans_2 PF11951.8 CCF37610.1 - 3e-10 39.5 0.1 5.4e-10 38.6 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF37610.1 - 1.4e-06 28.3 12.3 2.9e-06 27.3 12.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Herpes_UL25 PF01499.16 CCF37610.1 - 0.081 11.4 0.0 0.13 10.7 0.0 1.3 1 0 0 1 1 1 0 Herpesvirus UL25 family Fungal_trans PF04082.18 CCF37611.1 - 3.7e-15 55.7 0.2 7.2e-15 54.7 0.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF37611.1 - 5.4e-07 29.6 8.6 9.3e-07 28.9 8.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_hydro_20 PF00728.22 CCF37612.1 - 1.1e-28 100.6 0.0 5.5e-28 98.4 0.0 2.0 1 1 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glyco_hydro_20b PF02838.15 CCF37612.1 - 1.1e-07 32.6 0.1 3.7e-07 31.0 0.0 1.8 2 0 0 2 2 2 1 Glycosyl hydrolase family 20, domain 2 Rhomboid PF01694.22 CCF37613.1 - 3.4e-35 121.3 9.2 3.4e-35 121.3 9.2 2.1 3 0 0 3 3 3 1 Rhomboid family DNA_pol_B PF00136.21 CCF37614.1 - 3.1e-150 500.9 3.9 5e-150 500.2 3.9 1.3 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 CCF37614.1 - 2.4e-77 260.4 0.1 6.2e-77 259.0 0.0 1.8 2 0 0 2 2 2 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 CCF37614.1 - 2.5e-17 63.1 6.6 6.1e-17 61.9 6.6 1.7 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta DNA_pol_B_exo2 PF10108.9 CCF37614.1 - 0.002 17.9 0.0 0.0039 16.9 0.0 1.4 1 0 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.6 CCF37614.1 - 0.0027 17.7 0.2 0.024 14.7 0.2 2.6 1 1 0 1 1 1 1 RNase_H superfamily DNA_pol_B_2 PF03175.13 CCF37614.1 - 0.013 14.4 1.6 0.025 13.5 0.1 2.1 2 1 0 2 2 2 0 DNA polymerase type B, organellar and viral C1_1 PF00130.22 CCF37614.1 - 0.085 12.8 9.4 0.043 13.7 0.7 2.7 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF1948 PF09185.10 CCF37614.1 - 0.2 11.5 1.8 0.22 11.4 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1948) ELFV_dehydrog PF00208.21 CCF37615.1 - 7.7e-86 287.8 4.9 9.6e-86 287.4 4.9 1.1 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.18 CCF37615.1 - 2.5e-51 173.0 0.0 5.1e-51 171.9 0.0 1.6 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain NAD_binding_7 PF13241.6 CCF37615.1 - 0.033 14.6 0.1 0.098 13.1 0.1 1.8 2 0 0 2 2 2 0 Putative NAD(P)-binding Glyco_hydro_16 PF00722.21 CCF37616.1 - 2.1e-10 40.3 0.4 2.9e-10 39.9 0.4 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 NTP_transferase PF00483.23 CCF37618.1 - 5.3e-31 108.1 0.0 6.6e-31 107.8 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.24 CCF37618.1 - 9.2e-09 34.7 6.5 1.4e-06 27.7 0.0 3.6 3 1 0 3 3 3 2 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 CCF37618.1 - 1.1e-06 29.0 0.0 1.7e-06 28.5 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain TRAPPC-Trs85 PF12739.7 CCF37619.1 - 1.5e-117 393.0 0.0 2.4e-117 392.3 0.0 1.3 1 0 0 1 1 1 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit Snf7 PF03357.21 CCF37620.1 - 3.7e-17 62.4 14.2 5.2e-17 62.0 13.5 1.5 1 1 0 1 1 1 1 Snf7 HAUS-augmin3 PF14932.6 CCF37620.1 - 0.014 15.0 5.7 0.014 15.0 5.7 2.3 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 3 DUF4778 PF16008.5 CCF37620.1 - 1.1 9.3 9.8 0.089 12.8 1.6 2.2 1 1 0 2 2 2 0 Domain of unknown function (DUF4778) MCU PF04678.13 CCF37620.1 - 1.5 8.9 10.6 3.9 7.5 0.9 2.4 1 1 1 2 2 2 0 Mitochondrial calcium uniporter DUF948 PF06103.11 CCF37620.1 - 7.6 6.9 14.5 1.1 9.6 2.1 3.2 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF948) Glyco_hydro_28 PF00295.17 CCF37621.1 - 6.3e-35 120.8 0.4 2.3e-32 112.3 0.1 2.1 1 1 1 2 2 2 2 Glycosyl hydrolases family 28 Mcl1_mid PF12341.8 CCF37621.1 - 0.02 14.3 0.1 0.047 13.0 0.0 1.6 2 0 0 2 2 2 0 Minichromosome loss protein, Mcl1, middle region SMYLE_N PF18615.1 CCF37622.1 - 0.18 11.4 0.0 0.4 10.2 0.0 1.5 2 0 0 2 2 2 0 Short myomegalin-like EB1 binding proteins, N-terminal domain PKD_channel PF08016.12 CCF37623.1 - 0.00019 20.3 4.0 0.057 12.1 0.3 2.2 2 0 0 2 2 2 2 Polycystin cation channel Sm_multidrug_ex PF06695.11 CCF37623.1 - 2.3 8.9 5.8 0.7 10.5 1.5 2.2 2 0 0 2 2 2 0 Putative small multi-drug export protein Fasciclin PF02469.22 CCF37625.1 - 1.3e-44 151.5 6.1 9e-24 84.1 1.0 2.1 2 0 0 2 2 2 2 Fasciclin domain AA_permease_2 PF13520.6 CCF37626.1 - 5.1e-56 190.3 21.4 5.8e-56 190.1 21.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CCF37626.1 - 2.3e-07 29.8 19.5 2.9e-07 29.4 19.5 1.1 1 0 0 1 1 1 1 Amino acid permease Aa_trans PF01490.18 CCF37626.1 - 2.4e-05 23.2 9.4 3.1e-05 22.9 9.4 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Tetraspanin PF00335.20 CCF37626.1 - 0.39 10.4 4.5 0.7 9.6 1.0 2.4 2 0 0 2 2 2 0 Tetraspanin family LysM PF01476.20 CCF37627.1 - 4.6e-12 45.8 0.0 4.8e-06 26.5 0.0 2.1 2 0 0 2 2 2 2 LysM domain HTH_23 PF13384.6 CCF37627.1 - 0.01 15.6 0.0 0.96 9.3 0.0 2.2 2 0 0 2 2 2 0 Homeodomain-like domain HTH_Tnp_1 PF01527.20 CCF37627.1 - 0.018 15.4 0.0 0.55 10.6 0.0 2.1 2 0 0 2 2 2 0 Transposase zf-met PF12874.7 CCF37629.1 - 0.17 12.4 1.0 0.52 10.8 0.2 2.2 2 0 0 2 2 2 0 Zinc-finger of C2H2 type CFEM PF05730.11 CCF37630.1 - 7.3e-11 42.0 11.6 9e-11 41.7 11.6 1.1 1 0 0 1 1 1 1 CFEM domain Gamma-thionin PF00304.20 CCF37630.1 - 0.51 10.6 5.9 0.41 10.9 1.9 2.1 2 0 0 2 2 2 0 Gamma-thionin family LMWPc PF01451.21 CCF37631.1 - 8.3e-40 136.4 0.0 9.5e-40 136.3 0.0 1.0 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase p450 PF00067.22 CCF37633.1 - 5.4e-51 173.8 0.0 7.1e-51 173.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 CCF37634.1 - 2.4e-66 224.4 0.0 3.3e-66 223.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 adh_short_C2 PF13561.6 CCF37635.1 - 3.6e-62 210.0 0.1 4.1e-62 209.8 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF37635.1 - 1.3e-46 158.5 0.5 1.5e-46 158.3 0.5 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF37635.1 - 2.4e-13 50.4 2.1 3.4e-13 49.9 2.1 1.2 1 0 0 1 1 1 1 KR domain IreB PF06135.12 CCF37635.1 - 0.16 12.2 0.0 0.31 11.3 0.0 1.4 1 0 0 1 1 1 0 IreB regulatory phosphoprotein APH PF01636.23 CCF37636.1 - 2.2e-09 37.6 0.7 8.1e-09 35.7 0.0 2.0 2 0 0 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 CCF37636.1 - 0.15 11.0 0.0 0.23 10.4 0.0 1.1 1 0 0 1 1 1 0 Haspin like kinase domain DHDPS PF00701.22 CCF37638.1 - 4.5e-28 97.8 0.0 5.3e-28 97.6 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family DUF818 PF05677.12 CCF37638.1 - 0.086 11.8 0.0 0.12 11.3 0.0 1.1 1 0 0 1 1 1 0 Chlamydia CHLPS protein (DUF818) Aldo_ket_red PF00248.21 CCF37639.1 - 1.8e-46 158.7 0.0 2.2e-46 158.4 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family DapB_N PF01113.20 CCF37639.1 - 0.15 12.2 0.6 8.8 6.5 0.1 2.3 1 1 1 2 2 2 0 Dihydrodipicolinate reductase, N-terminus Complex1_LYR_2 PF13233.6 CCF37641.1 - 5.9e-21 75.0 0.1 8.4e-21 74.5 0.1 1.2 1 0 0 1 1 1 1 Complex1_LYR-like Syja_N PF02383.18 CCF37642.1 - 1.3e-09 37.8 0.0 1.5e-09 37.7 0.0 1.1 1 0 0 1 1 1 1 SacI homology domain Ribosomal_L7Ae PF01248.26 CCF37643.1 - 1.2e-24 85.9 0.1 1.5e-24 85.5 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PELOTA_1 PF15608.6 CCF37643.1 - 0.00043 20.1 0.0 0.00054 19.8 0.0 1.2 1 0 0 1 1 1 1 PELOTA RNA binding domain ATP-synt_C PF00137.21 CCF37644.1 - 4.9e-34 116.5 33.3 7.7e-22 77.4 14.6 2.1 2 0 0 2 2 2 2 ATP synthase subunit C MFS_5 PF05631.14 CCF37647.1 - 5.3e-09 35.5 2.6 5.3e-09 35.5 2.6 1.4 1 1 0 1 1 1 1 Sugar-tranasporters, 12 TM MFS_1 PF07690.16 CCF37647.1 - 0.013 14.5 8.5 0.024 13.6 8.5 1.6 1 1 0 1 1 1 0 Major Facilitator Superfamily DUF1686 PF07937.11 CCF37647.1 - 0.021 14.7 1.1 5.3 6.9 0.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1686) PhoLip_ATPase_C PF16212.5 CCF37647.1 - 1.3 8.7 7.4 2 8.1 7.4 1.5 1 1 0 1 1 1 0 Phospholipid-translocating P-type ATPase C-terminal O-FucT PF10250.9 CCF37648.1 - 0.00079 19.2 0.0 0.00093 19.0 0.0 1.1 1 0 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase DDE_1 PF03184.19 CCF37649.1 - 7.7e-23 81.0 0.1 3.8e-22 78.8 0.1 2.0 1 1 0 1 1 1 1 DDE superfamily endonuclease adh_short PF00106.25 CCF37650.1 - 1.1e-43 149.0 0.2 1.3e-43 148.7 0.2 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF37650.1 - 1e-35 123.4 0.1 1.1e-35 123.3 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF37650.1 - 3.7e-13 49.8 0.5 5.4e-13 49.2 0.5 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF37650.1 - 0.00051 19.6 0.1 0.00086 18.8 0.1 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CCF37650.1 - 0.00083 18.8 0.0 0.0014 18.1 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 CCF37650.1 - 0.0055 16.6 0.0 0.01 15.7 0.0 1.5 1 1 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 CCF37650.1 - 0.0076 15.4 0.0 0.011 14.9 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein HSP70 PF00012.20 CCF37651.1 - 3.7e-59 200.4 16.0 5e-56 190.1 1.0 2.8 2 1 1 3 3 3 3 Hsp70 protein MreB_Mbl PF06723.13 CCF37651.1 - 0.0048 15.8 0.4 0.012 14.4 0.1 1.8 2 0 0 2 2 2 1 MreB/Mbl protein Lyase_8_N PF08124.11 CCF37651.1 - 0.14 11.0 1.0 0.36 9.7 1.0 1.6 1 0 0 1 1 1 0 Polysaccharide lyase family 8, N terminal alpha-helical domain DUF3484 PF11983.8 CCF37651.1 - 0.19 12.8 1.4 2 9.6 0.0 2.9 2 0 0 2 2 2 0 Membrane-attachment and polymerisation-promoting switch EMP70 PF02990.16 CCF37652.1 - 1.7e-36 126.0 0.0 2.1e-36 125.7 0.0 1.0 1 0 0 1 1 1 1 Endomembrane protein 70 Arrestin_N PF00339.29 CCF37654.1 - 1.6e-05 25.0 0.0 0.00013 22.1 0.0 2.5 2 1 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Bul1_C PF04426.12 CCF37654.1 - 0.00023 20.7 0.0 0.00042 19.8 0.0 1.4 1 0 0 1 1 1 1 Bul1 C terminus Bul1_N PF04425.12 CCF37654.1 - 0.035 12.9 2.6 0.63 8.7 0.4 2.8 2 1 1 3 3 3 0 Bul1 N terminus Archaeal_AmoA PF12942.7 CCF37655.1 - 0.13 11.9 0.0 0.24 11.1 0.0 1.3 1 0 0 1 1 1 0 Archaeal ammonia monooxygenase subunit A (AmoA) Epimerase PF01370.21 CCF37656.1 - 6.5e-11 42.2 0.0 1e-10 41.5 0.0 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CCF37656.1 - 2.3e-07 30.1 0.0 2.9e-07 29.8 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 CCF37656.1 - 1.8e-06 28.0 0.0 2.5e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 CCF37656.1 - 4.6e-05 23.0 0.0 6.4e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 CCF37656.1 - 0.0002 20.6 0.0 0.11 11.6 0.0 2.1 2 0 0 2 2 2 2 Male sterility protein Polysacc_synt_2 PF02719.15 CCF37656.1 - 0.00066 18.9 0.0 0.0008 18.6 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NmrA PF05368.13 CCF37656.1 - 0.0013 18.4 0.0 0.0021 17.7 0.0 1.4 1 1 0 1 1 1 1 NmrA-like family adh_short PF00106.25 CCF37656.1 - 0.011 15.2 0.0 0.023 14.2 0.0 1.6 1 0 0 1 1 1 0 short chain dehydrogenase Cutinase PF01083.22 CCF37658.1 - 1.4e-46 158.7 1.1 1.7e-46 158.5 1.1 1.0 1 0 0 1 1 1 1 Cutinase PE-PPE PF08237.11 CCF37658.1 - 6.2e-06 25.9 0.1 8.5e-06 25.5 0.1 1.2 1 0 0 1 1 1 1 PE-PPE domain VirJ PF06057.11 CCF37658.1 - 0.036 13.9 0.0 0.052 13.4 0.0 1.2 1 0 0 1 1 1 0 Bacterial virulence protein (VirJ) Abhydrolase_2 PF02230.16 CCF37658.1 - 0.066 13.0 0.0 0.15 11.9 0.0 1.5 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Abhydrolase_1 PF00561.20 CCF37658.1 - 0.1 12.2 0.0 0.15 11.6 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Ferric_reduct PF01794.19 CCF37659.1 - 7.6e-20 71.3 9.9 7.6e-20 71.3 9.9 2.2 2 0 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 CCF37659.1 - 0.0013 18.8 0.0 0.0075 16.3 0.0 2.2 2 0 0 2 2 2 1 FAD-binding domain DUF4405 PF14358.6 CCF37659.1 - 6 7.5 12.9 7.5 7.2 1.7 3.8 3 1 0 3 3 3 0 Domain of unknown function (DUF4405) MARVEL PF01284.23 CCF37660.1 - 8.3e-07 29.1 3.9 9.9e-07 28.9 3.9 1.2 1 0 0 1 1 1 1 Membrane-associating domain YqhR PF11085.8 CCF37660.1 - 2.2 8.2 8.8 3.2 7.7 8.8 1.2 1 0 0 1 1 1 0 Conserved membrane protein YqhR Phage_holin_3_6 PF07332.11 CCF37660.1 - 6.5 6.8 19.1 0.072 13.1 6.8 2.0 1 1 1 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III BAR PF03114.18 CCF37662.1 - 7.7e-15 55.2 0.8 1.4e-14 54.4 0.7 1.5 1 1 1 2 2 2 1 BAR domain SH3_9 PF14604.6 CCF37662.1 - 1.6e-09 37.5 0.1 3e-09 36.6 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 CCF37662.1 - 2.1e-09 36.8 0.2 4.1e-09 35.9 0.2 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 CCF37662.1 - 6.2e-08 32.2 0.1 1.2e-07 31.3 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain DUF2203 PF09969.9 CCF37662.1 - 0.19 12.4 0.6 0.7 10.6 0.4 1.8 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) DUF2439 PF10382.9 CCF37664.1 - 4.4e-28 97.4 0.1 9e-28 96.4 0.1 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF2439) LysM PF01476.20 CCF37665.1 - 1.3e-13 50.7 0.5 0.0041 17.1 0.0 4.2 5 0 0 5 5 5 3 LysM domain ETF_alpha PF00766.19 CCF37665.1 - 0.073 13.1 2.3 10 6.3 0.1 2.4 2 0 0 2 2 2 0 Electron transfer flavoprotein FAD-binding domain Ldh_2 PF02615.14 CCF37665.1 - 0.4 9.8 3.8 0.59 9.2 3.8 1.2 1 0 0 1 1 1 0 Malate/L-lactate dehydrogenase TAA-Trp-ring PF15401.6 CCF37665.1 - 3.3 8.2 8.2 9.6 6.8 0.2 3.1 3 0 0 3 3 3 0 Tryptophan-ring motif of head of Trimeric autotransporter adhesin Glyco_hydro_18 PF00704.28 CCF37666.1 - 3.4e-63 214.3 1.7 5.8e-63 213.5 0.6 1.9 2 0 0 2 2 2 1 Glycosyl hydrolases family 18 Chitin_bind_1 PF00187.19 CCF37666.1 - 8.8e-10 38.9 17.7 8.8e-10 38.9 17.7 4.7 6 0 0 6 6 6 2 Chitin recognition protein Aldo_ket_red PF00248.21 CCF37667.1 - 1.1e-51 175.8 0.0 1.3e-51 175.6 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Pkinase PF00069.25 CCF37668.1 - 2e-60 204.4 0.0 3.3e-60 203.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF37668.1 - 2.6e-37 128.5 0.0 3.7e-37 128.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF37668.1 - 7e-10 38.7 0.0 2.7e-09 36.7 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 CCF37668.1 - 0.00011 21.2 0.0 0.00011 21.2 0.0 2.1 2 0 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 CCF37668.1 - 0.0013 18.7 1.8 0.016 15.1 0.0 2.5 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 CCF37668.1 - 0.033 13.6 0.0 0.07 12.5 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 CCF37668.1 - 0.1 11.6 0.0 0.16 11.0 0.0 1.1 1 0 0 1 1 1 0 Seadornavirus VP7 Peptidase_M16_C PF05193.21 CCF37671.1 - 1.6e-17 64.2 0.0 5e-14 52.7 0.0 2.6 2 0 0 2 2 2 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 CCF37671.1 - 1.5e-06 28.3 0.0 9.1e-06 25.7 0.0 2.2 3 0 0 3 3 3 1 Insulinase (Peptidase family M16) M16C_assoc PF08367.11 CCF37671.1 - 0.0025 17.0 3.0 0.89 8.6 0.0 2.3 2 0 0 2 2 2 2 Peptidase M16C associated RecA_dep_nuc PF16786.5 CCF37671.1 - 0.046 13.9 0.0 0.45 10.7 0.0 2.3 2 0 0 2 2 2 0 Recombination enhancement, RecA-dependent nuclease Sporozoite_P67 PF05642.11 CCF37671.1 - 0.67 8.0 6.0 0.99 7.4 6.0 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen RNA_pol_3_Rpc31 PF11705.8 CCF37671.1 - 4.9 7.3 14.5 0.086 13.1 7.3 1.7 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 HeLo PF14479.6 CCF37672.1 - 5.7e-24 85.1 0.5 1.4e-22 80.5 0.5 2.0 1 1 0 1 1 1 1 Prion-inhibition and propagation Helo_like_N PF17111.5 CCF37672.1 - 0.062 12.7 0.0 0.088 12.2 0.0 1.3 1 0 0 1 1 1 0 Fungal N-terminal domain of STAND proteins ETX_MTX2 PF03318.13 CCF37673.1 - 0.0042 16.9 1.7 0.0076 16.0 1.7 1.3 1 0 0 1 1 1 1 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2 WD40 PF00400.32 CCF37677.1 - 9e-05 23.2 0.0 0.26 12.2 0.0 3.3 3 0 0 3 3 3 1 WD domain, G-beta repeat Nup160 PF11715.8 CCF37677.1 - 0.019 13.7 0.0 0.02 13.6 0.0 1.1 1 0 0 1 1 1 0 Nucleoporin Nup120/160 INSIG PF07281.12 CCF37678.1 - 2e-89 298.8 0.9 2.6e-89 298.5 0.9 1.1 1 0 0 1 1 1 1 Insulin-induced protein (INSIG) p450 PF00067.22 CCF37679.1 - 6.4e-29 101.0 0.0 7.3e-29 100.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 SMC_N PF02463.19 CCF37681.1 - 3.9e-12 46.1 0.4 6.5e-12 45.3 0.4 1.3 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 CCF37681.1 - 0.0012 19.1 0.0 0.0023 18.2 0.0 1.5 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain SbcCD_C PF13558.6 CCF37681.1 - 0.049 13.9 0.0 0.13 12.5 0.0 1.7 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit DUF1664 PF07889.12 CCF37681.1 - 0.28 11.2 11.4 6.9 6.7 0.5 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) zf-C4H2 PF10146.9 CCF37681.1 - 0.34 11.2 14.3 0.31 11.3 12.1 2.0 1 1 0 1 1 1 0 Zinc finger-containing protein COQ9 PF08511.11 CCF37682.1 - 4.6e-30 103.2 0.1 6.9e-30 102.6 0.1 1.3 1 0 0 1 1 1 1 COQ9 PRP1_N PF06424.12 CCF37686.1 - 0.045 14.2 0.4 0.045 14.2 0.4 2.7 2 1 0 2 2 2 0 PRP1 splicing factor, N-terminal DUF5428 PF17493.2 CCF37687.1 - 0.018 15.4 0.1 0.026 14.9 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5428) MFS_1 PF07690.16 CCF37688.1 - 1.9e-06 27.0 4.2 1.9e-06 27.0 4.2 1.9 2 0 0 2 2 2 2 Major Facilitator Superfamily Nudix_N PF12535.8 CCF37689.1 - 0.1 12.2 0.0 13 5.5 0.0 2.4 2 0 0 2 2 2 0 Hydrolase of X-linked nucleoside diphosphate N terminal dCMP_cyt_deam_2 PF08211.12 CCF37690.1 - 0.3 11.3 1.2 0.39 10.9 0.1 1.7 2 0 0 2 2 2 0 Cytidine and deoxycytidylate deaminase zinc-binding region MFS_1 PF07690.16 CCF37691.1 - 3.9e-41 141.1 49.5 5e-39 134.2 49.5 2.2 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF37691.1 - 1e-12 47.7 10.0 1e-12 47.7 10.0 2.4 3 0 0 3 3 3 1 Sugar (and other) transporter ThiF PF00899.21 CCF37692.1 - 2.2e-16 60.0 0.0 2.7e-16 59.7 0.0 1.0 1 0 0 1 1 1 1 ThiF family NUDIX PF00293.28 CCF37693.1 - 9.6e-26 90.4 0.0 1.4e-25 89.8 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain MatE PF01554.18 CCF37694.1 - 9.4e-55 184.7 29.3 1.3e-32 112.7 11.1 2.3 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.6 CCF37694.1 - 0.00092 19.3 9.2 0.00092 19.3 9.2 3.9 3 1 1 5 5 5 1 Polysaccharide biosynthesis C-terminal domain Form-deh_trans PF09163.11 CCF37694.1 - 2.1 8.2 6.8 0.11 12.3 0.9 1.9 2 0 0 2 2 2 0 Formate dehydrogenase N, transmembrane F-box-like PF12937.7 CCF37695.1 - 0.043 13.7 0.3 5.8 6.9 0.0 3.1 3 0 0 3 3 3 0 F-box-like Totivirus_coat PF05518.11 CCF37695.1 - 6.9 4.6 7.8 10 4.0 7.8 1.1 1 0 0 1 1 1 0 Totivirus coat protein Ribosomal_L22 PF00237.19 CCF37696.1 - 3.7e-41 139.5 0.0 5.3e-41 139.0 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e LTD PF00932.19 CCF37696.1 - 0.12 12.7 0.0 0.15 12.4 0.0 1.5 1 1 0 1 1 1 0 Lamin Tail Domain Amidohydro_2 PF04909.14 CCF37698.1 - 1.5e-22 80.8 0.4 1.8e-22 80.5 0.4 1.1 1 0 0 1 1 1 1 Amidohydrolase CHD5 PF04420.14 CCF37699.1 - 4.7e-62 208.6 3.2 6.2e-62 208.1 3.2 1.2 1 0 0 1 1 1 1 CHD5-like protein Peptidase_S49_N PF08496.10 CCF37699.1 - 0.072 13.1 2.4 0.31 11.1 0.4 2.1 2 0 0 2 2 2 0 Peptidase family S49 N-terminal DUF565 PF04483.12 CCF37699.1 - 0.44 11.1 2.6 3.7 8.2 0.7 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF565) IES5 PF17335.2 CCF37700.1 - 0.046 14.0 0.0 0.073 13.3 0.0 1.4 1 0 0 1 1 1 0 Ino80 complex subunit 5 Neisseria_TspB PF05616.13 CCF37701.1 - 0.22 10.0 0.0 0.24 9.9 0.0 1.0 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein COesterase PF00135.28 CCF37702.1 - 1.7e-48 165.8 0.0 1.3e-47 162.8 0.0 1.9 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CCF37702.1 - 0.00022 21.1 0.1 0.00068 19.6 0.1 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CCF37702.1 - 0.0087 15.6 0.5 0.045 13.2 0.1 2.0 2 0 0 2 2 2 1 Prolyl oligopeptidase family Esterase_phd PF10503.9 CCF37702.1 - 0.021 14.3 0.5 0.045 13.2 0.3 1.4 1 1 0 1 1 1 0 Esterase PHB depolymerase Esterase PF00756.20 CCF37702.1 - 0.15 11.7 0.3 0.25 11.0 0.1 1.4 2 0 0 2 2 2 0 Putative esterase XPG_I_2 PF12813.7 CCF37704.1 - 3.1e-29 102.2 0.0 6e-29 101.3 0.0 1.4 1 0 0 1 1 1 1 XPG domain containing SAM_adeno_trans PF01887.16 CCF37704.1 - 0.22 11.0 0.2 0.67 9.3 0.0 1.8 2 0 0 2 2 2 0 S-adenosyl-l-methionine hydroxide adenosyltransferase Pribosyltran_N PF13793.6 CCF37706.1 - 5.9e-43 145.5 0.1 5.7e-41 139.1 0.0 2.3 2 0 0 2 2 2 2 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 CCF37706.1 - 3.1e-34 118.6 0.1 9.7e-29 100.7 0.0 2.2 2 0 0 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 CCF37706.1 - 2.2e-09 37.0 0.0 6.4e-05 22.5 0.0 2.5 2 0 0 2 2 2 2 Phosphoribosyl transferase domain PAP_assoc PF03828.19 CCF37707.1 - 1.6e-17 63.4 0.0 9.2e-12 45.0 0.0 2.6 2 0 0 2 2 2 2 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 CCF37707.1 - 0.00087 19.5 0.0 0.0021 18.3 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain DUF3405 PF11885.8 CCF37709.1 - 5.1e-183 609.4 1.1 5.1e-183 609.4 1.1 2.0 2 1 0 2 2 2 1 Protein of unknown function (DUF3405) Ytp1 PF10355.9 CCF37710.1 - 2.6e-67 226.9 18.7 2.6e-67 226.9 18.7 2.4 2 1 0 2 2 2 1 Protein of unknown function (Ytp1) DUF2427 PF10348.9 CCF37710.1 - 2.1e-32 111.0 4.4 2.1e-32 111.0 4.4 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF2427) Cytochrom_B561 PF03188.16 CCF37710.1 - 0.009 16.2 7.5 0.009 16.2 7.5 3.3 5 1 0 5 5 5 1 Eukaryotic cytochrome b561 DUF2530 PF10745.9 CCF37710.1 - 0.2 11.9 5.5 1.1 9.5 0.3 3.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2530) MID_pPIWI_RE PF18157.1 CCF37711.1 - 0.12 12.6 3.2 0.15 12.3 3.2 1.1 1 0 0 1 1 1 0 MID domain of pPIWI_RE PP1_bind PF15276.6 CCF37712.1 - 0.097 13.0 0.4 0.1 12.9 0.4 1.3 1 1 0 1 1 1 0 Protein phosphatase 1 binding Myosin_head PF00063.21 CCF37714.1 - 1.6e-258 859.5 0.0 2.3e-258 858.9 0.0 1.2 1 0 0 1 1 1 1 Myosin head (motor domain) IQ PF00612.27 CCF37714.1 - 2.7e-22 76.4 31.5 9.3e-07 28.1 1.1 6.8 6 0 0 6 6 6 5 IQ calmodulin-binding motif GAS PF13851.6 CCF37714.1 - 0.00076 18.9 18.5 0.0021 17.5 18.5 1.7 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding Myosin_N PF02736.19 CCF37714.1 - 0.00077 19.2 1.0 0.00077 19.2 1.0 2.3 2 0 0 2 2 2 1 Myosin N-terminal SH3-like domain Baculo_PEP_C PF04513.12 CCF37714.1 - 0.00077 19.5 3.7 0.0019 18.2 3.7 1.8 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus AAA_16 PF13191.6 CCF37714.1 - 0.0015 18.9 0.0 0.006 17.0 0.0 2.1 1 0 0 1 1 1 1 AAA ATPase domain DUF812 PF05667.11 CCF37714.1 - 0.0038 16.2 15.1 0.0056 15.6 15.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF812) AAA_22 PF13401.6 CCF37714.1 - 0.0075 16.5 2.4 0.0086 16.4 0.1 2.3 2 1 0 2 2 1 1 AAA domain FlaC_arch PF05377.11 CCF37714.1 - 0.018 15.5 6.9 0.092 13.1 0.1 2.9 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Sec34 PF04136.15 CCF37714.1 - 0.047 13.6 6.0 0.12 12.3 6.0 1.7 1 0 0 1 1 1 0 Sec34-like family IQCJ-SCHIP1 PF15157.6 CCF37714.1 - 0.066 13.1 6.1 2.6 7.9 0.5 3.3 1 1 1 3 3 3 0 Fusion protein IQCJ-SCHIP1 with IQ-like motif HSF_DNA-bind PF00447.17 CCF37714.1 - 0.073 13.7 0.2 0.34 11.6 0.2 2.1 1 0 0 1 1 1 0 HSF-type DNA-binding Phage_GP20 PF06810.11 CCF37714.1 - 0.13 12.1 10.6 0.051 13.4 3.4 2.5 1 1 1 2 2 2 0 Phage minor structural protein GP20 TolA_bind_tri PF16331.5 CCF37714.1 - 0.13 12.3 13.6 2.1 8.5 8.0 2.7 1 1 1 2 2 2 0 TolA binding protein trimerisation DUF5407 PF17401.2 CCF37714.1 - 0.25 11.6 1.1 0.75 10.1 1.1 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5407) ABC_tran PF00005.27 CCF37714.1 - 0.52 10.8 3.0 1.1 9.7 0.0 2.7 2 0 0 2 2 2 0 ABC transporter TMCO5 PF14992.6 CCF37714.1 - 0.67 9.5 14.1 1.4 8.5 14.1 1.5 1 0 0 1 1 1 0 TMCO5 family ATG16 PF08614.11 CCF37714.1 - 0.85 9.8 22.3 3 8.0 7.1 2.8 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Jnk-SapK_ap_N PF09744.9 CCF37714.1 - 0.91 9.7 21.4 0.39 10.9 8.5 2.8 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 TMPIT PF07851.13 CCF37714.1 - 1.1 8.5 9.6 2.8 7.1 9.6 1.7 1 0 0 1 1 1 0 TMPIT-like protein Atg14 PF10186.9 CCF37714.1 - 5.2 6.1 16.0 10 5.1 16.0 1.5 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DivIC PF04977.15 CCF37714.1 - 5.4 6.9 18.6 0.89 9.4 3.8 4.3 2 1 1 4 4 3 0 Septum formation initiator TMF_TATA_bd PF12325.8 CCF37714.1 - 5.5 7.3 17.0 2.7 8.3 11.9 2.5 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF4665 PF15679.5 CCF37714.1 - 5.6 7.7 9.8 2.8 8.6 3.8 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4665) DUF4164 PF13747.6 CCF37714.1 - 6.9 7.0 10.5 12 6.3 8.7 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4164) CENP-F_leu_zip PF10473.9 CCF37714.1 - 7.6 6.6 21.0 0.63 10.1 5.7 2.5 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1664 PF07889.12 CCF37714.1 - 7.6 6.6 8.8 7.5 6.6 0.4 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) EMP24_GP25L PF01105.24 CCF37714.1 - 8 6.4 14.1 1.4e+02 2.3 14.1 2.4 1 1 0 1 1 1 0 emp24/gp25L/p24 family/GOLD DUF5595 PF18077.1 CCF37714.1 - 8.8 6.5 8.8 41 4.4 0.4 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF5595) Pkinase PF00069.25 CCF37715.1 - 9e-64 215.4 0.0 1.3e-63 214.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF37715.1 - 1.1e-47 162.5 0.0 1.6e-47 162.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF37715.1 - 4.7e-09 36.0 0.0 4.7e-07 29.4 0.0 2.1 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.14 CCF37715.1 - 0.00066 19.1 0.0 0.0039 16.6 0.0 2.0 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 CCF37715.1 - 0.0083 14.9 0.3 0.0083 14.9 0.3 2.3 2 1 0 2 2 2 1 Fungal protein kinase APH PF01636.23 CCF37715.1 - 0.016 15.1 0.0 0.038 13.9 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family FTA2 PF13095.6 CCF37715.1 - 0.036 13.7 0.0 0.064 12.9 0.0 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 TPR_12 PF13424.6 CCF37716.1 - 1.5e-09 38.0 0.1 1.9e-09 37.7 0.1 1.1 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_10 PF13374.6 CCF37716.1 - 0.00012 21.8 0.8 0.0034 17.2 0.2 2.5 2 1 0 2 2 2 1 Tetratricopeptide repeat PFK PF00365.20 CCF37719.1 - 2.8e-57 194.2 0.0 3.3e-57 194.0 0.0 1.1 1 0 0 1 1 1 1 Phosphofructokinase FAD_binding_1 PF00667.20 CCF37720.1 - 1.1e-44 152.6 0.0 1.5e-44 152.2 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 CCF37720.1 - 3.7e-09 37.2 0.0 1e-08 35.8 0.0 1.8 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain RVT_1 PF00078.27 CCF37721.1 - 9.1e-05 22.1 0.0 0.0002 21.0 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) FdsD PF11390.8 CCF37721.1 - 0.029 14.7 0.0 0.096 13.0 0.0 1.9 1 0 0 1 1 1 0 NADH-dependant formate dehydrogenase delta subunit FdsD UPF0122 PF04297.14 CCF37721.1 - 0.13 12.5 0.3 0.34 11.2 0.0 1.7 2 0 0 2 2 2 0 Putative helix-turn-helix protein, YlxM / p13 like MFS_1 PF07690.16 CCF37722.1 - 2.5e-43 148.4 42.5 2.5e-43 148.4 42.5 1.8 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF37722.1 - 4.1e-15 55.6 10.6 4.1e-15 55.6 10.6 2.6 3 0 0 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.13 CCF37722.1 - 4.8e-07 28.6 13.2 1.1e-06 27.4 13.2 1.6 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) AMP-binding PF00501.28 CCF37723.1 - 2.1e-17 62.9 0.1 2.9e-17 62.4 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme NPCC PF08058.11 CCF37724.1 - 7.5e-28 97.2 0.0 1.1e-27 96.7 0.0 1.2 1 0 0 1 1 1 1 Nuclear pore complex component Hid1 PF12722.7 CCF37725.1 - 3.9e-274 911.8 0.0 4.8e-274 911.5 0.0 1.0 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein Dymeclin PF09742.9 CCF37725.1 - 7.9e-105 351.6 0.4 1e-104 351.3 0.4 1.0 1 0 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein DUF913 PF06025.12 CCF37725.1 - 0.0085 15.1 0.5 0.025 13.6 0.5 1.7 2 0 0 2 2 2 1 Domain of Unknown Function (DUF913) Adeno_GP19K PF04881.13 CCF37725.1 - 0.019 15.0 0.0 0.04 13.9 0.0 1.5 1 0 0 1 1 1 0 Adenovirus GP19K Ank_4 PF13637.6 CCF37725.1 - 0.055 14.1 0.0 1.9 9.2 0.0 2.8 3 0 0 3 3 3 0 Ankyrin repeats (many copies) Response_reg PF00072.24 CCF37726.1 - 1.3e-20 73.6 0.0 2.8e-20 72.6 0.0 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HATPase_c PF02518.26 CCF37726.1 - 3.5e-20 72.6 0.3 8.8e-20 71.3 0.1 1.9 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CCF37726.1 - 2.2e-11 43.6 0.1 8.8e-11 41.7 0.1 2.1 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain Ank_2 PF12796.7 CCF37728.1 - 9.4e-18 64.6 1.1 6.3e-10 39.5 0.1 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CCF37728.1 - 3.2e-14 52.8 1.4 1.5e-08 34.7 0.2 3.3 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 CCF37728.1 - 4.6e-10 39.8 3.6 5.9e-05 23.5 0.2 3.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCF37728.1 - 3e-09 36.4 0.2 0.00052 20.3 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 CCF37728.1 - 6.8e-09 35.8 2.0 1.8e-05 24.9 0.2 3.4 4 0 0 4 4 4 2 Ankyrin repeat ZapB PF06005.12 CCF37730.1 - 2e-05 24.9 9.8 0.0099 16.3 4.6 2.6 2 0 0 2 2 2 2 Cell division protein ZapB HALZ PF02183.18 CCF37730.1 - 3.8e-05 23.8 6.1 0.0019 18.4 0.8 2.6 2 0 0 2 2 2 2 Homeobox associated leucine zipper CENP-K PF11802.8 CCF37730.1 - 0.00049 19.8 3.4 0.0009 18.9 3.4 1.3 1 0 0 1 1 1 1 Centromere-associated protein K Fez1 PF06818.15 CCF37730.1 - 0.0037 17.8 7.7 0.0078 16.7 7.7 1.5 1 0 0 1 1 1 1 Fez1 SHE3 PF17078.5 CCF37730.1 - 0.0042 16.8 9.5 0.083 12.6 4.4 2.3 1 1 1 2 2 2 1 SWI5-dependent HO expression protein 3 bZIP_1 PF00170.21 CCF37730.1 - 0.0056 16.8 1.6 0.019 15.1 1.6 1.9 1 0 0 1 1 1 1 bZIP transcription factor Lge1 PF11488.8 CCF37730.1 - 0.017 15.3 0.3 0.048 13.8 0.3 1.7 1 0 0 1 1 1 0 Transcriptional regulatory protein LGE1 NPV_P10 PF05531.12 CCF37730.1 - 0.025 15.1 3.6 0.033 14.7 0.4 2.7 3 0 0 3 3 2 0 Nucleopolyhedrovirus P10 protein YabA PF06156.13 CCF37730.1 - 0.033 14.8 3.8 0.44 11.2 0.9 2.4 2 0 0 2 2 2 0 Initiation control protein YabA DUF3450 PF11932.8 CCF37730.1 - 0.07 12.4 9.6 0.072 12.4 4.5 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) CENP-F_leu_zip PF10473.9 CCF37730.1 - 0.093 12.8 11.0 1.1 9.2 9.7 2.9 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Uds1 PF15456.6 CCF37730.1 - 0.12 12.6 5.7 2.1 8.5 0.9 2.4 1 1 1 2 2 2 0 Up-regulated During Septation BRE1 PF08647.11 CCF37730.1 - 0.12 12.4 7.3 0.021 14.9 2.9 1.9 2 0 0 2 2 1 0 BRE1 E3 ubiquitin ligase DUF2205 PF10224.9 CCF37730.1 - 0.13 12.3 5.9 0.1 12.6 0.6 2.4 2 0 0 2 2 2 0 Short coiled-coil protein V_ATPase_I PF01496.19 CCF37730.1 - 0.13 10.1 0.7 0.19 9.6 0.7 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Tropomyosin PF00261.20 CCF37730.1 - 0.14 11.5 10.4 3.1 7.1 10.4 2.1 1 1 0 1 1 1 0 Tropomyosin Snapin_Pallidin PF14712.6 CCF37730.1 - 0.15 12.5 6.1 1.2 9.6 0.3 2.6 2 0 0 2 2 2 0 Snapin/Pallidin Sec34 PF04136.15 CCF37730.1 - 0.22 11.4 4.6 2.6 7.9 1.3 2.3 2 0 0 2 2 2 0 Sec34-like family ADIP PF11559.8 CCF37730.1 - 0.24 11.5 11.0 0.18 11.9 6.5 2.2 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding GAS PF13851.6 CCF37730.1 - 0.42 9.9 8.4 1.5 8.2 1.6 2.2 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Fib_alpha PF08702.10 CCF37730.1 - 0.47 10.6 3.3 0.83 9.8 0.5 2.4 2 1 1 3 3 2 0 Fibrinogen alpha/beta chain family DUF4407 PF14362.6 CCF37730.1 - 0.5 9.7 3.5 0.86 8.9 3.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TMF_TATA_bd PF12325.8 CCF37730.1 - 0.7 10.1 8.3 0.44 10.8 1.1 2.3 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding GIT_CC PF16559.5 CCF37730.1 - 0.79 9.6 4.4 12 5.8 0.4 2.7 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor HAP1_N PF04849.13 CCF37730.1 - 0.96 8.6 11.9 2.6 7.1 2.2 2.2 1 1 1 2 2 2 0 HAP1 N-terminal conserved region DHR10 PF18595.1 CCF37730.1 - 1.3 9.1 10.2 2.7 8.1 3.7 2.5 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain UPF0242 PF06785.11 CCF37730.1 - 1.3 9.1 8.6 17 5.4 8.7 2.2 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Spc7 PF08317.11 CCF37730.1 - 1.5 7.6 10.0 3.7 6.3 4.9 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF4201 PF13870.6 CCF37730.1 - 2 8.1 9.5 16 5.1 8.7 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) DUF4200 PF13863.6 CCF37730.1 - 2.2 8.7 5.9 4.3 7.8 0.6 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) DivIC PF04977.15 CCF37730.1 - 2.5 7.9 6.8 1.4 8.7 1.0 2.6 2 0 0 2 2 2 0 Septum formation initiator Laminin_II PF06009.12 CCF37730.1 - 3.3 7.7 9.4 0.5 10.4 2.5 2.6 2 1 1 3 3 3 0 Laminin Domain II ABC_tran_CTD PF16326.5 CCF37730.1 - 3.4 8.0 6.9 32 4.9 0.3 3.4 2 1 0 2 2 2 0 ABC transporter C-terminal domain Taxilin PF09728.9 CCF37730.1 - 3.5 6.7 10.0 14 4.7 10.1 1.8 1 1 0 1 1 1 0 Myosin-like coiled-coil protein ERM PF00769.19 CCF37730.1 - 6.8 6.4 15.9 0.45 10.3 9.8 2.0 2 1 0 2 2 1 0 Ezrin/radixin/moesin family BLOC1_2 PF10046.9 CCF37730.1 - 7.7 6.9 6.9 2.9 8.2 0.3 2.7 2 1 1 3 3 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Chromo PF00385.24 CCF37731.1 - 2.2e-07 30.6 0.1 2.2e-07 30.6 0.1 1.6 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain ELM2 PF01448.24 CCF37731.1 - 0.0072 17.1 1.2 0.017 15.9 1.2 1.6 1 0 0 1 1 1 1 ELM2 domain Myc_N PF01056.18 CCF37731.1 - 0.02 14.8 0.1 0.031 14.2 0.1 1.4 2 0 0 2 2 2 0 Myc amino-terminal region Peptidase_S41 PF03572.18 CCF37732.1 - 1.3e-08 34.6 0.0 4.7e-08 32.8 0.0 1.9 1 1 0 1 1 1 1 Peptidase family S41 PAPA-1 PF04795.12 CCF37733.1 - 0.00016 22.4 3.4 0.00027 21.7 3.4 1.4 1 0 0 1 1 1 1 PAPA-1-like conserved region TFIIB PF00382.19 CCF37735.1 - 5.8e-41 138.4 1.2 2.2e-23 82.1 0.0 2.2 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 CCF37735.1 - 1.5e-14 53.2 1.4 2.7e-14 52.4 1.4 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_C PF02984.19 CCF37735.1 - 0.00031 20.8 0.0 1.3 9.1 0.1 2.4 2 1 0 2 2 2 2 Cyclin, C-terminal domain RB_B PF01857.20 CCF37735.1 - 0.0097 15.9 0.0 0.029 14.4 0.0 1.7 1 1 1 2 2 2 1 Retinoblastoma-associated protein B domain Trp_repressor PF01371.19 CCF37735.1 - 0.034 14.3 0.0 9.5 6.4 0.0 2.5 2 0 0 2 2 2 0 Trp repressor protein Sigma70_r4_2 PF08281.12 CCF37735.1 - 0.034 13.8 0.0 0.11 12.1 0.0 1.9 1 0 0 1 1 1 0 Sigma-70, region 4 YceG PF02618.16 CCF37735.1 - 0.034 13.7 0.1 0.12 11.9 0.1 1.7 1 1 0 1 1 1 0 YceG-like family zf-ribbon_3 PF13248.6 CCF37735.1 - 0.06 12.8 1.4 0.8 9.2 0.0 2.5 2 0 0 2 2 2 0 zinc-ribbon domain HTH_Tnp_ISL3 PF13542.6 CCF37735.1 - 0.11 11.9 0.1 2.2 7.8 0.1 2.6 2 1 0 2 2 2 0 Helix-turn-helix domain of transposase family ISL3 Thioredoxin PF00085.20 CCF37736.1 - 6.5e-15 55.0 0.0 8.7e-15 54.6 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.13 CCF37736.1 - 0.018 14.4 0.0 0.022 14.1 0.0 1.1 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family Wzy_C PF04932.15 CCF37736.1 - 0.052 13.2 0.0 0.063 12.9 0.0 1.0 1 0 0 1 1 1 0 O-Antigen ligase Thioredoxin_7 PF13899.6 CCF37736.1 - 0.1 12.8 0.0 0.19 11.9 0.0 1.5 1 1 0 1 1 1 0 Thioredoxin-like Vta1 PF04652.16 CCF37737.1 - 2.4e-53 180.0 5.3 3e-53 179.7 4.0 1.7 2 0 0 2 2 2 1 Vta1 like Vta1_C PF18097.1 CCF37737.1 - 1.8e-16 59.5 0.0 1.8e-16 59.5 0.0 2.3 3 0 0 3 3 3 1 Vta1 C-terminal domain adh_short_C2 PF13561.6 CCF37738.1 - 1.3e-60 204.9 0.2 1.5e-60 204.6 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF37738.1 - 2.1e-44 151.4 0.3 2.5e-44 151.1 0.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF37738.1 - 4.1e-09 36.6 0.1 6.8e-09 35.9 0.1 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF37738.1 - 4.5e-05 23.0 0.1 7.5e-05 22.3 0.1 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1776 PF08643.10 CCF37738.1 - 0.0017 17.8 0.0 0.0026 17.2 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) ADH_zinc_N PF00107.26 CCF37738.1 - 0.0052 16.8 0.2 0.018 15.0 0.2 2.0 1 1 0 1 1 1 1 Zinc-binding dehydrogenase UQ_con PF00179.26 CCF37739.1 - 6.1e-48 162.0 0.0 6.9e-48 161.9 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 CCF37739.1 - 0.00054 19.7 0.0 0.00073 19.3 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 CCF37739.1 - 0.0042 16.9 0.1 0.0082 16.0 0.1 1.5 1 1 0 1 1 1 1 UEV domain RWD PF05773.22 CCF37739.1 - 0.071 13.4 0.0 0.091 13.1 0.0 1.3 1 0 0 1 1 1 0 RWD domain WD40 PF00400.32 CCF37740.1 - 4.4e-09 36.8 23.0 0.00079 20.2 0.6 5.3 6 0 0 6 6 6 4 WD domain, G-beta repeat RWD PF05773.22 CCF37740.1 - 0.01 16.1 0.0 0.019 15.2 0.0 1.4 1 0 0 1 1 1 0 RWD domain WD40 PF00400.32 CCF37741.1 - 3.5e-21 75.1 12.8 2.4e-07 31.3 0.1 7.0 7 1 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF37741.1 - 0.00043 20.5 0.7 12 6.3 0.0 4.5 4 1 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain VCBS PF13517.6 CCF37741.1 - 0.063 13.9 0.3 0.44 11.2 0.1 2.6 3 0 0 3 3 3 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Arm PF00514.23 CCF37742.1 - 8.5e-08 32.0 12.6 0.12 12.5 0.0 7.5 8 0 0 8 8 8 2 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 CCF37742.1 - 7.1e-05 23.2 11.6 0.047 14.2 0.0 6.8 8 0 0 8 8 8 2 HEAT-like repeat HEAT PF02985.22 CCF37742.1 - 8.4e-05 22.5 9.5 26 5.4 0.0 7.2 7 0 0 7 7 7 1 HEAT repeat TIMELESS PF04821.14 CCF37742.1 - 0.0058 15.9 1.0 0.079 12.2 0.0 2.8 3 0 0 3 3 3 1 Timeless protein DUF747 PF05346.11 CCF37742.1 - 0.047 13.1 0.0 0.08 12.4 0.0 1.3 1 0 0 1 1 1 0 Eukaryotic membrane protein family DUF3361 PF11841.8 CCF37742.1 - 0.13 12.2 4.9 7 6.6 0.0 3.6 4 1 0 4 4 4 0 Domain of unknown function (DUF3361) HEAT_2 PF13646.6 CCF37742.1 - 0.61 10.5 7.2 1.3 9.5 0.1 4.8 5 0 0 5 5 5 0 HEAT repeats zf-C2H2 PF00096.26 CCF37743.1 - 0.0031 17.9 21.6 0.04 14.4 0.8 5.1 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CCF37743.1 - 0.031 14.7 0.4 0.031 14.7 0.4 3.7 5 0 0 5 5 5 0 Zinc-finger double domain zf-CHCC PF10276.9 CCF37743.1 - 0.088 12.9 2.8 4.5 7.4 0.4 2.5 2 0 0 2 2 2 0 Zinc-finger domain zf-C2H2_4 PF13894.6 CCF37743.1 - 0.81 10.7 22.9 0.18 12.7 1.4 5.3 4 0 0 4 4 4 0 C2H2-type zinc finger zf-C2H2_2 PF12756.7 CCF37743.1 - 3.7 7.9 11.9 12 6.3 2.7 3.6 2 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) DSPc PF00782.20 CCF37744.1 - 0.031 14.1 0.0 0.046 13.5 0.0 1.3 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain MIP PF00230.20 CCF37746.1 - 6.3e-41 140.5 13.7 7.8e-41 140.3 13.7 1.0 1 0 0 1 1 1 1 Major intrinsic protein Aminotran_3 PF00202.21 CCF37747.1 - 2.5e-05 23.1 0.0 3.4e-05 22.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III DUF2207 PF09972.9 CCF37748.1 - 0.19 10.4 0.0 1.7 7.3 0.1 1.9 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) YrhK PF14145.6 CCF37748.1 - 0.22 11.4 0.1 0.22 11.4 0.1 2.9 4 0 0 4 4 4 0 YrhK-like protein Peptidase_U4 PF03419.13 CCF37748.1 - 0.25 10.6 1.0 0.49 9.6 1.0 1.4 1 0 0 1 1 1 0 Sporulation factor SpoIIGA DUF4395 PF14340.6 CCF37748.1 - 1.3 9.4 9.0 0.32 11.3 1.6 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4395) Tyrosinase PF00264.20 CCF37749.1 - 2.4e-54 185.0 0.3 3.1e-54 184.6 0.3 1.1 1 0 0 1 1 1 1 Common central domain of tyrosinase Glyco_hydro_47 PF01532.20 CCF37750.1 - 4.7e-21 75.2 0.0 5e-21 75.1 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 IATP PF04568.12 CCF37751.1 - 0.057 13.8 1.6 0.087 13.3 1.6 1.3 1 0 0 1 1 1 0 Mitochondrial ATPase inhibitor, IATP VIT1 PF01988.19 CCF37752.1 - 2.3e-63 213.9 5.4 3.4e-63 213.4 5.4 1.2 1 0 0 1 1 1 1 VIT family SLATT_fungal PF18142.1 CCF37752.1 - 0.029 14.4 0.0 0.064 13.3 0.0 1.7 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain Oxysterol_BP PF01237.18 CCF37753.1 - 2.5e-49 168.1 0.0 5.3e-47 160.4 0.0 2.2 1 1 0 1 1 1 1 Oxysterol-binding protein AKAP2_C PF15304.6 CCF37753.1 - 0.043 13.1 0.4 0.043 13.1 0.4 1.8 2 0 0 2 2 2 0 A-kinase anchor protein 2 C-terminus UQ_con PF00179.26 CCF37754.1 - 2.5e-40 137.3 0.0 3.6e-40 136.8 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UBA_3 PF09288.10 CCF37754.1 - 2.1e-06 27.5 0.3 4.1e-06 26.5 0.3 1.5 1 0 0 1 1 1 1 Fungal ubiquitin-associated domain Prok-E2_B PF14461.6 CCF37754.1 - 0.0005 19.8 0.0 0.00087 19.0 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 CCF37754.1 - 0.047 14.0 0.0 0.067 13.5 0.0 1.3 1 0 0 1 1 1 0 RWD domain UEV PF05743.13 CCF37754.1 - 0.053 13.4 0.0 0.082 12.8 0.0 1.3 1 0 0 1 1 1 0 UEV domain DUF1421 PF07223.11 CCF37754.1 - 0.15 11.9 0.4 0.32 10.9 0.4 1.6 1 0 0 1 1 1 0 UBA-like domain (DUF1421) AAA PF00004.29 CCF37755.1 - 1.7e-15 57.6 0.0 3.3e-15 56.7 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 CCF37755.1 - 7.8e-12 45.0 0.2 1.5e-11 44.0 0.2 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain DUF815 PF05673.13 CCF37755.1 - 0.0002 20.6 0.0 0.0003 20.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_16 PF13191.6 CCF37755.1 - 0.00053 20.4 0.0 0.001 19.5 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain Prot_ATP_OB_N PF17758.1 CCF37755.1 - 0.002 17.7 0.0 0.0044 16.6 0.0 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB N-terminal domain AAA_28 PF13521.6 CCF37755.1 - 0.0024 18.1 0.0 0.0058 16.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CCF37755.1 - 0.0031 17.8 0.0 0.0065 16.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 CCF37755.1 - 0.0035 17.5 0.2 0.013 15.6 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 CCF37755.1 - 0.0059 16.6 0.1 0.01 15.9 0.1 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 CCF37755.1 - 0.0073 16.1 0.0 0.013 15.3 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain IstB_IS21 PF01695.17 CCF37755.1 - 0.013 15.2 0.0 0.025 14.3 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_3 PF07726.11 CCF37755.1 - 0.016 15.1 0.0 0.028 14.3 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TIP49 PF06068.13 CCF37755.1 - 0.023 13.9 0.0 0.034 13.4 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_18 PF13238.6 CCF37755.1 - 0.037 14.6 0.3 0.073 13.6 0.0 1.7 2 0 0 2 2 1 0 AAA domain Mg_chelatase PF01078.21 CCF37755.1 - 0.045 13.1 0.1 0.082 12.3 0.1 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 CCF37755.1 - 0.049 14.0 0.0 0.089 13.2 0.0 1.4 1 0 0 1 1 1 0 RNA helicase Zeta_toxin PF06414.12 CCF37755.1 - 0.069 12.4 0.1 0.13 11.5 0.1 1.3 1 0 0 1 1 1 0 Zeta toxin DUF2075 PF09848.9 CCF37755.1 - 0.11 11.7 0.0 0.15 11.3 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_25 PF13481.6 CCF37755.1 - 0.12 12.0 0.1 0.33 10.5 0.1 1.7 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 CCF37755.1 - 0.17 11.6 0.1 0.27 10.9 0.1 1.2 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 CCF37755.1 - 0.19 11.7 0.0 0.31 11.0 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE PhoH PF02562.16 CCF37755.1 - 0.2 11.1 0.1 0.33 10.4 0.1 1.3 1 0 0 1 1 1 0 PhoH-like protein ATPase PF06745.13 CCF37755.1 - 0.2 11.0 0.0 0.34 10.2 0.0 1.3 1 0 0 1 1 1 0 KaiC Aa_trans PF01490.18 CCF37756.1 - 1.6e-59 201.7 32.4 2e-59 201.3 32.4 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein EST1_DNA_bind PF10373.9 CCF37757.1 - 1.6e-22 80.4 1.1 2.6e-22 79.6 0.0 1.8 2 1 0 2 2 2 1 Est1 DNA/RNA binding domain EST1 PF10374.9 CCF37757.1 - 1.8e-22 80.5 0.7 1.8e-22 80.5 0.7 1.9 2 0 0 2 2 2 1 Telomerase activating protein Est1 TMEM154 PF15102.6 CCF37758.1 - 0.15 12.0 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 TMEM154 protein family G10 PF01125.17 CCF37759.1 - 8e-64 213.8 3.7 9e-64 213.7 3.7 1.0 1 0 0 1 1 1 1 G10 protein Complex1_LYR_2 PF13233.6 CCF37760.1 - 2.8e-07 31.2 0.1 3.8e-07 30.8 0.1 1.3 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.15 CCF37760.1 - 6.2e-05 23.0 0.2 0.00013 21.9 0.2 1.6 1 1 0 1 1 1 1 Complex 1 protein (LYR family) KilA-N PF04383.13 CCF37761.1 - 0.072 12.9 0.0 0.19 11.6 0.0 1.7 1 1 0 1 1 1 0 KilA-N domain RR_TM4-6 PF06459.12 CCF37761.1 - 1.9 8.2 10.1 3.6 7.3 10.1 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SUN PF03856.13 CCF37762.1 - 1.7e-91 306.1 11.7 2.4e-91 305.6 11.7 1.2 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) TALPID3 PF15324.6 CCF37762.1 - 3.8 5.0 18.0 5.3 4.6 18.0 1.1 1 0 0 1 1 1 0 Hedgehog signalling target Peptidase_S8 PF00082.22 CCF37764.1 - 2.6e-23 82.7 0.1 3.6e-23 82.3 0.1 1.2 1 0 0 1 1 1 1 Subtilase family PA PF02225.22 CCF37764.1 - 2.2e-08 34.0 0.0 6.6e-08 32.5 0.0 1.8 1 0 0 1 1 1 1 PA domain RPT PF13446.6 CCF37764.1 - 0.015 15.2 0.0 0.033 14.1 0.0 1.5 1 0 0 1 1 1 0 A repeated domain in UCH-protein SET PF00856.28 CCF37765.1 - 2e-08 34.8 0.0 1.7e-07 31.8 0.0 2.0 1 1 1 2 2 2 1 SET domain DUF1679 PF07914.11 CCF37766.1 - 0.00055 18.9 0.1 0.00067 18.6 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) Pkinase PF00069.25 CCF37766.1 - 0.0024 17.3 1.7 0.012 15.0 1.7 1.9 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.23 CCF37766.1 - 0.016 15.2 0.0 0.021 14.8 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Acyl_transf_3 PF01757.22 CCF37767.1 - 1.2e-26 93.6 28.7 1.6e-26 93.2 28.7 1.1 1 0 0 1 1 1 1 Acyltransferase family Glycos_transf_2 PF00535.26 CCF37768.1 - 5.5e-21 75.1 0.0 8e-21 74.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 CCF37768.1 - 4.6e-19 68.6 0.0 7.4e-19 67.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_trans_2_3 PF13632.6 CCF37768.1 - 2.5e-16 60.2 1.6 2.5e-16 60.2 1.6 2.3 3 0 0 3 3 3 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 CCF37768.1 - 1.4e-12 48.1 0.0 1.8e-12 47.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Cellulose_synt PF03552.14 CCF37768.1 - 3e-06 26.0 0.6 0.0037 15.8 0.2 2.3 2 1 0 2 2 2 2 Cellulose synthase Helo_like_N PF17111.5 CCF37769.1 - 5.4e-08 32.5 0.7 8e-08 31.9 0.7 1.2 1 0 0 1 1 1 1 Fungal N-terminal domain of STAND proteins SesA PF17107.5 CCF37769.1 - 0.071 13.3 0.4 0.55 10.4 0.1 2.4 2 0 0 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Abhydrolase_3 PF07859.13 CCF37771.1 - 0.017 15.0 0.0 0.03 14.2 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Ion_trans_2 PF07885.16 CCF37772.1 - 9.8e-35 118.4 23.2 2.1e-20 72.5 2.4 3.0 3 0 0 3 3 3 2 Ion channel Ion_trans PF00520.31 CCF37772.1 - 0.006 15.8 0.9 0.006 15.8 0.9 3.0 3 1 0 3 3 3 2 Ion transport protein DUF2569 PF10754.9 CCF37772.1 - 7.6 7.0 14.1 0.54 10.7 6.2 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2569) UDPGT PF00201.18 CCF37773.1 - 2.2e-14 53.1 0.0 1.5e-12 47.1 0.0 2.2 2 0 0 2 2 2 2 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_transf_28 PF03033.20 CCF37773.1 - 0.00089 19.3 0.0 0.0018 18.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain Glyco_transf_4 PF13439.6 CCF37773.1 - 0.13 12.2 0.2 0.43 10.6 0.2 1.8 1 1 0 1 1 1 0 Glycosyltransferase Family 4 Glyco_tran_28_C PF04101.16 CCF37773.1 - 0.16 11.9 0.0 0.24 11.4 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase family 28 C-terminal domain adh_short_C2 PF13561.6 CCF37773.1 - 0.47 10.0 3.7 1.3 8.5 0.5 2.5 2 1 1 3 3 3 0 Enoyl-(Acyl carrier protein) reductase Trp_DMAT PF11991.8 CCF37774.1 - 1.2e-97 327.6 0.0 1.5e-97 327.3 0.0 1.1 1 0 0 1 1 1 1 Tryptophan dimethylallyltransferase Sel1 PF08238.12 CCF37775.1 - 4.1e-18 65.4 28.1 3.7e-07 30.6 0.3 7.6 7 0 0 7 7 7 6 Sel1 repeat TPR_1 PF00515.28 CCF37775.1 - 0.0006 19.5 0.4 0.0033 17.2 0.4 2.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_6 PF13174.6 CCF37775.1 - 7.2 7.5 10.3 4.8 8.0 0.1 4.4 4 1 0 4 4 4 0 Tetratricopeptide repeat zf-C2H2 PF00096.26 CCF37776.1 - 1.8e-22 78.4 25.6 1.8e-05 24.9 0.2 4.9 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CCF37776.1 - 1.3e-17 63.3 31.4 1.7e-06 28.2 1.2 6.4 6 0 0 6 6 6 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 CCF37776.1 - 4.9e-12 45.6 22.9 0.0041 17.8 1.3 4.8 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CCF37776.1 - 3e-06 27.4 0.1 4.6 7.6 0.0 4.4 4 0 0 4 4 4 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CCF37776.1 - 0.00081 19.7 7.9 2.7 8.5 0.0 4.3 4 0 0 4 4 4 2 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 CCF37776.1 - 0.0011 18.7 8.1 0.02 14.7 0.8 3.3 3 0 0 3 3 3 2 zinc-finger C2H2-type zf_UBZ PF18439.1 CCF37776.1 - 0.0026 17.3 2.0 1.2 8.8 0.2 3.3 3 0 0 3 3 3 2 Ubiquitin-Binding Zinc Finger zf-C2HC_2 PF13913.6 CCF37776.1 - 0.1 12.5 6.6 4.5 7.3 0.2 3.6 3 0 0 3 3 3 0 zinc-finger of a C2HC-type C1_4 PF07975.12 CCF37776.1 - 0.13 12.5 0.7 3 8.2 0.0 2.7 2 1 1 3 3 3 0 TFIIH C1-like domain Zn-ribbon_8 PF09723.10 CCF37776.1 - 0.32 11.2 8.6 2.2 8.4 0.7 3.3 1 1 3 4 4 4 0 Zinc ribbon domain zf-C2H2_aberr PF17017.5 CCF37776.1 - 0.34 11.0 1.1 3.1 7.9 0.1 2.1 2 0 0 2 2 2 0 Aberrant zinc-finger zf-MYST PF17772.1 CCF37776.1 - 1.1 9.0 3.9 4.2 7.1 0.1 2.9 3 0 0 3 3 3 0 MYST family zinc finger domain DUF2256 PF10013.9 CCF37776.1 - 2.2 8.5 8.3 22 5.3 0.0 3.6 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2256) XPA_N PF01286.18 CCF37776.1 - 2.6 8.2 7.3 0.84 9.7 0.5 3.1 4 0 0 4 4 4 0 XPA protein N-terminal zf-LYAR PF08790.11 CCF37776.1 - 2.9 7.9 4.2 6.2 6.8 0.1 3.3 4 0 0 4 4 4 0 LYAR-type C2HC zinc finger DZR PF12773.7 CCF37776.1 - 3.5 7.7 8.5 1.6e+02 2.4 8.5 2.4 1 1 0 1 1 1 0 Double zinc ribbon FOXP-CC PF16159.5 CCF37776.1 - 3.6 8.3 7.0 19 6.0 0.2 3.3 3 1 1 4 4 3 0 FOXP coiled-coil domain Ogr_Delta PF04606.12 CCF37776.1 - 5.1 7.2 8.5 13 5.8 0.3 2.4 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger SQHop_cyclase_N PF13249.6 CCF37778.1 - 7.5e-29 100.7 0.1 1.3e-28 100.0 0.1 1.4 1 1 0 1 1 1 1 Squalene-hopene cyclase N-terminal domain Prenyltrans PF00432.21 CCF37778.1 - 3.5e-08 33.1 0.2 5.5e-06 26.0 0.0 2.6 2 0 0 2 2 2 2 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_C PF13243.6 CCF37778.1 - 0.0072 15.5 0.0 0.015 14.4 0.0 1.4 1 1 0 1 1 1 1 Squalene-hopene cyclase C-terminal domain ABM PF03992.16 CCF37779.1 - 0.0023 18.0 0.2 0.019 15.1 0.1 2.0 2 0 0 2 2 2 1 Antibiotic biosynthesis monooxygenase DUF4937 PF16291.5 CCF37779.1 - 0.024 14.9 0.1 0.048 13.9 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4937 Cu-oxidase_2 PF07731.14 CCF37780.1 - 4.3e-18 65.4 0.2 4.8e-18 65.2 0.2 1.1 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase_3 PF07732.15 CCF37780.1 - 0.049 13.6 0.0 0.064 13.3 0.0 1.2 1 0 0 1 1 1 0 Multicopper oxidase MFS_1 PF07690.16 CCF37781.1 - 8.7e-32 110.4 71.2 3.1e-25 88.9 37.0 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF37781.1 - 1.8e-14 53.5 28.6 7.3e-10 38.3 11.9 2.7 2 1 1 3 3 3 2 Sugar (and other) transporter adh_short PF00106.25 CCF37782.1 - 1.1e-35 122.9 0.0 8.7e-35 120.0 0.0 1.9 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF37782.1 - 4.9e-27 95.0 0.0 4.6e-17 62.4 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF37782.1 - 0.02 14.8 0.0 1.5 8.7 0.0 2.1 2 0 0 2 2 2 0 KR domain 2-Hacid_dh_C PF02826.19 CCF37782.1 - 0.025 14.0 0.0 0.04 13.3 0.0 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Fungal_trans PF04082.18 CCF37784.1 - 2.8e-11 42.9 1.1 8.3e-11 41.4 1.1 1.7 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF37784.1 - 1.1e-07 31.8 8.6 2.5e-07 30.7 8.6 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Phosphoesterase PF04185.14 CCF37786.1 - 1.5e-23 83.6 1.1 6.7e-23 81.5 1.1 1.8 1 1 0 1 1 1 1 Phosphoesterase family SUB1_ProdP9 PF18213.1 CCF37788.1 - 0.0043 16.9 0.0 0.0078 16.0 0.0 1.3 1 0 0 1 1 1 1 SUB1 protease Prodomain ProdP9 Pkinase PF00069.25 CCF37789.1 - 2.2e-05 23.9 0.0 3.5e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain TA_inhibitor PF17574.2 CCF37789.1 - 0.048 13.7 0.1 0.11 12.6 0.1 1.5 1 0 0 1 1 1 0 Inhibitor of toxin/antitoxin system (Gp4.5) Pkinase_Tyr PF07714.17 CCF37789.1 - 0.12 11.6 0.0 0.17 11.2 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase dsrm PF00035.26 CCF37791.1 - 0.0049 17.6 0.0 0.007 17.0 0.0 1.2 1 0 0 1 1 1 1 Double-stranded RNA binding motif DND1_DSRM PF14709.7 CCF37791.1 - 0.028 14.7 0.0 0.11 12.7 0.0 1.9 1 1 0 1 1 1 0 double strand RNA binding domain from DEAD END PROTEIN 1 DUF2850 PF11012.8 CCF37791.1 - 0.15 12.4 0.0 0.22 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2850) DUF918 PF06033.11 CCF37792.1 - 0.098 12.7 0.0 0.12 12.4 0.0 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF918) SKG6 PF08693.10 CCF37793.1 - 3.9e-08 32.6 0.9 8.8e-08 31.4 0.9 1.6 1 0 0 1 1 1 1 Transmembrane alpha-helix domain DUF4448 PF14610.6 CCF37793.1 - 0.00013 21.8 0.0 0.00021 21.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) Podoplanin PF05808.11 CCF37793.1 - 0.0013 18.8 1.1 0.0028 17.8 1.1 1.5 1 0 0 1 1 1 1 Podoplanin Rax2 PF12768.7 CCF37793.1 - 0.011 15.2 0.0 0.018 14.5 0.0 1.3 1 0 0 1 1 1 0 Cortical protein marker for cell polarity VSP PF03302.13 CCF37793.1 - 0.084 11.7 5.1 0.13 11.1 5.1 1.3 1 0 0 1 1 1 0 Giardia variant-specific surface protein TRI12 PF06609.13 CCF37794.1 - 7.9e-15 54.3 1.9 9.4e-15 54.0 1.9 1.0 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_1 PF07690.16 CCF37794.1 - 8.1e-07 28.3 19.8 4.2e-05 22.6 19.3 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily Transposase_28 PF04195.12 CCF37796.1 - 0.092 13.0 0.0 0.2 11.9 0.0 1.4 1 0 0 1 1 1 0 Putative gypsy type transposon LRR_6 PF13516.6 CCF37796.1 - 0.16 12.1 14.2 15 6.0 0.0 6.8 7 0 0 7 7 7 0 Leucine Rich repeat Barttin PF15462.6 CCF37796.1 - 0.93 9.2 4.0 2.7 7.7 2.5 2.2 2 0 0 2 2 2 0 Bartter syndrome, infantile, with sensorineural deafness (Barttin) RNA_pol_Rpc4 PF05132.14 CCF37797.1 - 0.072 13.5 5.4 0.07 13.6 5.4 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 SR-25 PF10500.9 CCF37797.1 - 0.1 12.2 21.1 0.14 11.8 21.1 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein PEX11 PF05648.14 CCF37797.1 - 0.32 10.4 1.1 0.35 10.3 1.1 1.1 1 0 0 1 1 1 0 Peroxisomal biogenesis factor 11 (PEX11) Presenilin PF01080.17 CCF37797.1 - 3.1 6.5 3.1 3.1 6.5 3.1 1.0 1 0 0 1 1 1 0 Presenilin Vfa1 PF08432.10 CCF37797.1 - 3.3 8.0 16.2 3.7 7.9 16.2 1.0 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Atrophin-1 PF03154.15 CCF37797.1 - 3.9 5.7 9.3 4.1 5.6 9.3 1.0 1 0 0 1 1 1 0 Atrophin-1 family Eapp_C PF10238.9 CCF37797.1 - 7.2 6.7 8.3 7.8 6.6 8.3 1.1 1 0 0 1 1 1 0 E2F-associated phosphoprotein CDC45 PF02724.14 CCF37797.1 - 9.4 4.4 7.8 10 4.3 7.8 1.0 1 0 0 1 1 1 0 CDC45-like protein Aldo_ket_red PF00248.21 CCF37798.1 - 5.2e-49 167.0 0.1 5.6e-47 160.4 0.1 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family YflT PF11181.8 CCF37798.1 - 0.097 13.2 0.1 0.72 10.4 0.0 2.3 3 0 0 3 3 3 0 Heat induced stress protein YflT DUF1833 PF08875.11 CCF37798.1 - 0.18 11.4 0.0 0.29 10.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1833) ADH_N PF08240.12 CCF37799.1 - 5.4e-27 93.8 0.4 5.4e-27 93.8 0.4 1.8 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCF37799.1 - 6.2e-15 55.3 0.4 1.2e-14 54.4 0.4 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 CCF37799.1 - 1.4e-06 28.0 0.1 0.013 15.0 0.0 2.6 2 1 0 2 2 2 2 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 CCF37799.1 - 0.01 15.2 0.7 0.01 15.2 0.7 1.7 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain UDPG_MGDP_dh_N PF03721.14 CCF37799.1 - 0.013 15.1 0.4 0.032 13.8 0.1 1.8 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain HI0933_like PF03486.14 CCF37799.1 - 0.013 14.2 0.3 0.02 13.6 0.3 1.2 1 0 0 1 1 1 0 HI0933-like protein ADH_N_2 PF16884.5 CCF37799.1 - 0.17 11.8 0.2 1.3 8.9 0.1 2.4 2 1 0 2 2 2 0 N-terminal domain of oxidoreductase 7tm_2 PF00002.24 CCF37800.1 - 0.08 12.2 0.0 0.11 11.7 0.0 1.2 1 0 0 1 1 1 0 7 transmembrane receptor (Secretin family) Abhydrolase_1 PF00561.20 CCF37801.1 - 4.4e-09 36.4 0.0 1.2e-08 34.9 0.0 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCF37801.1 - 1.4e-07 32.4 4.4 2.9e-06 28.1 4.4 2.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCF37801.1 - 1.4e-05 24.4 0.0 0.0017 17.6 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 DLH PF01738.18 CCF37801.1 - 0.2 11.2 0.0 0.34 10.4 0.0 1.3 1 0 0 1 1 1 0 Dienelactone hydrolase family GST_N PF02798.20 CCF37803.1 - 3.2e-07 30.6 0.0 6.9e-07 29.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CCF37803.1 - 4.8e-05 23.6 0.1 0.00014 22.1 0.1 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CCF37803.1 - 0.00091 19.2 0.0 0.0021 18.0 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 CCF37803.1 - 0.0023 18.3 0.0 0.006 17.0 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CCF37803.1 - 0.035 14.3 0.0 0.071 13.3 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 CCF37803.1 - 0.046 13.9 0.0 0.13 12.4 0.0 1.8 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain BPL_N PF09825.9 CCF37804.1 - 3e-41 141.8 0.0 3.9e-41 141.4 0.0 1.1 1 0 0 1 1 1 1 Biotin-protein ligase, N terminal BPL_LplA_LipB PF03099.19 CCF37804.1 - 3.6e-22 78.7 0.0 5.4e-22 78.1 0.0 1.3 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family IBN_N PF03810.19 CCF37807.1 - 6.4e-14 51.6 0.5 1.4e-11 44.2 0.0 4.1 3 1 1 4 4 4 2 Importin-beta N-terminal domain Xpo1 PF08389.12 CCF37807.1 - 0.00036 20.6 0.0 0.0094 16.0 0.0 2.8 2 0 0 2 2 2 1 Exportin 1-like protein NDK PF00334.19 CCF37809.1 - 4.2e-51 172.5 0.0 5.2e-51 172.2 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Glyco_hydro_31 PF01055.26 CCF37810.1 - 1.6e-136 456.0 3.0 2.4e-136 455.5 3.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 CCF37810.1 - 2.6e-23 82.1 0.5 8.4e-23 80.5 0.1 2.1 2 0 0 2 2 2 1 Galactose mutarotase-like DUF5110 PF17137.4 CCF37810.1 - 4.4e-06 26.9 1.0 1.7e-05 25.0 0.6 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF5110) MS_channel PF00924.18 CCF37811.1 - 1.5e-20 73.7 0.6 2.4e-20 73.0 0.6 1.3 1 0 0 1 1 1 1 Mechanosensitive ion channel EF-hand_7 PF13499.6 CCF37811.1 - 0.0073 16.7 0.1 0.021 15.2 0.1 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 CCF37811.1 - 0.036 13.6 0.2 0.12 12.0 0.2 1.9 1 0 0 1 1 1 0 EF hand EF-hand_6 PF13405.6 CCF37811.1 - 0.15 12.1 0.0 0.43 10.6 0.0 1.8 1 0 0 1 1 1 0 EF-hand domain IspA PF04279.15 CCF37811.1 - 1.7 8.8 8.4 0.11 12.7 2.8 1.8 2 0 0 2 2 2 0 Intracellular septation protein A UBD PF16455.5 CCF37812.1 - 4.8e-15 55.7 0.0 1e-14 54.6 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-binding domain ubiquitin PF00240.23 CCF37812.1 - 1.3e-06 28.1 0.0 2.5e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD_2 PF13881.6 CCF37812.1 - 0.006 16.7 0.0 0.01 15.9 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 CCF37812.1 - 0.0073 16.8 0.5 0.024 15.2 0.1 1.8 1 1 1 2 2 2 1 DUF2407 ubiquitin-like domain Adaptin_N PF01602.20 CCF37813.1 - 1.3e-95 320.9 13.2 1.3e-95 320.9 13.2 1.7 2 0 0 2 2 2 1 Adaptin N terminal region Coatamer_beta_C PF07718.12 CCF37813.1 - 3.9e-60 201.8 0.7 9e-60 200.6 0.7 1.7 1 0 0 1 1 1 1 Coatomer beta C-terminal region Coatomer_b_Cpla PF14806.6 CCF37813.1 - 3.8e-57 191.8 0.0 1.3e-56 190.1 0.0 1.9 1 0 0 1 1 1 1 Coatomer beta subunit appendage platform Cnd1 PF12717.7 CCF37813.1 - 5.9e-13 49.2 7.8 7.6e-11 42.3 0.1 3.0 1 1 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 CCF37813.1 - 1.3e-08 35.1 4.0 8.3e-05 22.9 0.0 4.3 2 2 1 3 3 3 2 HEAT repeats Coatomer_g_Cpla PF16381.5 CCF37813.1 - 0.0005 20.2 0.0 0.0016 18.6 0.0 2.0 1 0 0 1 1 1 1 Coatomer subunit gamma-1 C-terminal appendage platform HEAT PF02985.22 CCF37813.1 - 0.0012 18.9 0.5 4.1 7.9 0.0 4.6 4 0 0 4 4 4 1 HEAT repeat AP4E_app_platf PF14807.6 CCF37813.1 - 0.011 16.1 0.2 0.037 14.4 0.2 2.0 1 0 0 1 1 1 0 Adaptin AP4 complex epsilon appendage platform DUF5578 PF17741.1 CCF37813.1 - 0.021 14.3 3.6 1.9 7.9 0.1 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5578) HEAT_EZ PF13513.6 CCF37813.1 - 0.18 12.3 0.8 17 6.0 0.0 3.8 3 0 0 3 3 3 0 HEAT-like repeat RPN1_RPN2_N PF17781.1 CCF37814.1 - 5.2e-108 361.1 1.8 6.6e-108 360.8 1.8 1.1 1 0 0 1 1 1 1 RPN1/RPN2 N-terminal domain DUF848 PF05852.11 CCF37814.1 - 0.022 14.9 1.6 0.046 13.8 1.6 1.5 1 0 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) HAND PF09110.11 CCF37814.1 - 0.066 14.0 6.8 0.17 12.6 6.8 1.6 1 0 0 1 1 1 0 HAND RIO1 PF01163.22 CCF37815.1 - 3.5e-43 147.4 0.1 1.2e-30 106.5 0.0 2.2 2 0 0 2 2 2 2 RIO1 family Rio2_N PF09202.11 CCF37815.1 - 9.8e-30 102.6 0.0 2.7e-29 101.2 0.0 1.8 2 0 0 2 2 2 1 Rio2, N-terminal APH PF01636.23 CCF37815.1 - 1e-07 32.1 0.0 0.00088 19.3 0.0 2.8 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 CCF37815.1 - 2.7e-07 30.2 0.1 0.00077 18.9 0.0 2.5 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family RRM_1 PF00076.22 CCF37816.1 - 1.6e-15 56.6 0.0 1.1e-10 41.2 0.0 2.6 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Acetyltransf_1 PF00583.25 CCF37817.1 - 7.1e-07 29.5 0.1 1.8e-06 28.2 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CCF37817.1 - 0.00038 20.8 0.0 0.00081 19.8 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CCF37817.1 - 0.0018 18.2 0.0 0.0051 16.8 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain E1-E2_ATPase PF00122.20 CCF37818.1 - 6e-37 126.9 2.8 5.5e-36 123.8 0.4 3.3 3 1 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 CCF37818.1 - 1.6e-16 61.3 0.1 3.3e-16 60.2 0.1 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 CCF37818.1 - 9.8e-11 41.2 0.0 2.4e-10 39.9 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 CCF37818.1 - 0.0038 17.0 0.0 0.0069 16.1 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Baculo_11_kDa PF06143.11 CCF37818.1 - 0.22 11.1 1.5 0.57 9.8 1.5 1.7 1 0 0 1 1 1 0 Baculovirus 11 kDa family 4HBT_3 PF13622.6 CCF37819.1 - 8.3e-21 75.4 0.0 1e-20 75.1 0.0 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily COX5B PF01215.19 CCF37821.1 - 1.9e-56 189.3 0.1 2.4e-56 189.0 0.1 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Vb DUF4604 PF15377.6 CCF37822.1 - 2.5e-15 57.3 19.7 2.8e-15 57.2 19.7 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) HLH PF00010.26 CCF37823.1 - 2.3e-12 46.7 1.3 4.6e-12 45.7 1.3 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain TFIIA PF03153.13 CCF37823.1 - 0.47 10.4 20.3 0.61 10.0 20.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DivIC PF04977.15 CCF37823.1 - 3.8 7.4 9.9 0.096 12.5 1.4 2.4 2 1 0 2 2 2 0 Septum formation initiator DUF2985 PF11204.8 CCF37824.1 - 2.9e-39 133.1 1.4 2.9e-39 133.1 1.4 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF2985) Nuc_sug_transp PF04142.15 CCF37825.1 - 1.7e-10 40.6 1.0 1.1e-09 37.9 1.0 2.0 1 1 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 CCF37825.1 - 1e-09 38.7 23.7 3.7e-05 23.9 4.0 2.7 2 1 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 CCF37825.1 - 0.00043 19.7 2.0 0.00043 19.7 2.0 2.1 2 0 0 2 2 2 1 Triose-phosphate Transporter family PUNUT PF16913.5 CCF37825.1 - 0.00087 18.6 2.3 0.0009 18.6 0.3 1.9 2 0 0 2 2 2 1 Purine nucleobase transmembrane transport DUF423 PF04241.15 CCF37825.1 - 0.095 12.9 3.6 2 8.6 0.7 3.1 1 1 1 2 2 2 0 Protein of unknown function (DUF423) DUF2975 PF11188.8 CCF37825.1 - 0.77 9.6 15.3 25 4.8 0.0 3.6 2 1 0 2 2 2 0 Protein of unknown function (DUF2975) PDR_assoc PF08370.11 CCF37825.1 - 0.91 9.3 5.1 7.2 6.4 0.1 3.3 3 0 0 3 3 3 0 Plant PDR ABC transporter associated DUF2613 PF11021.8 CCF37825.1 - 6.1 7.0 8.7 1.4 9.1 0.6 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF2613) Yippee-Mis18 PF03226.14 CCF37826.1 - 5.1e-12 45.9 0.2 5.4e-12 45.8 0.2 1.0 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly RRM_1 PF00076.22 CCF37827.1 - 1.2e-16 60.3 0.0 1.9e-16 59.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1932 PF09130.11 CCF37829.1 - 4.4e-27 93.8 0.1 8.8e-27 92.9 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1932) FAD_binding_4 PF01565.23 CCF37832.1 - 1.5e-23 83.1 2.1 3.1e-23 82.1 2.1 1.6 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 CCF37832.1 - 7.2e-06 26.0 0.4 1.7e-05 24.8 0.4 1.7 1 0 0 1 1 1 1 Berberine and berberine like SKIP_SNW PF02731.15 CCF37834.1 - 1.6e-71 239.2 4.8 1.6e-71 239.2 4.8 2.5 2 0 0 2 2 2 1 SKIP/SNW domain DUF4603 PF15376.6 CCF37834.1 - 2.9 5.2 18.5 4.2 4.6 18.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4603) zf-C2H2_4 PF13894.6 CCF37835.1 - 0.055 14.3 0.3 0.055 14.3 0.3 2.1 2 0 0 2 2 2 0 C2H2-type zinc finger Frag1 PF10277.9 CCF37836.1 - 3.6e-25 88.8 6.2 4.2e-25 88.6 6.2 1.0 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family Pkinase PF00069.25 CCF37837.1 - 2.4e-64 217.2 0.0 2.9e-64 217.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF37837.1 - 2.1e-35 122.2 0.0 3e-35 121.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF37837.1 - 0.00078 18.8 0.0 0.0019 17.6 0.0 1.6 2 0 0 2 2 2 1 Kinase-like Sec10 PF07393.11 CCF37838.1 - 7e-79 266.1 0.0 8.2e-79 265.8 0.0 1.0 1 0 0 1 1 1 1 Exocyst complex component Sec10 ESSS PF10183.9 CCF37839.1 - 0.03 14.5 0.0 0.03 14.5 0.0 1.0 1 0 0 1 1 1 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) ApbA PF02558.16 CCF37840.1 - 2e-33 115.2 0.0 2.7e-33 114.7 0.0 1.2 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ApbA_C PF08546.11 CCF37840.1 - 5e-28 97.8 0.0 9.5e-28 96.9 0.0 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal DUF3292 PF11696.8 CCF37843.1 - 1.8e-243 809.7 0.0 2.1e-243 809.5 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3292) Pex24p PF06398.11 CCF37843.1 - 0.059 12.3 0.0 0.091 11.7 0.0 1.2 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin Abhydrolase_6 PF12697.7 CCF37844.1 - 7e-23 82.4 2.6 8.3e-23 82.1 2.6 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCF37844.1 - 6.1e-06 25.7 0.0 1.2e-05 24.8 0.0 1.5 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_5 PF12695.7 CCF37844.1 - 0.003 17.3 0.0 0.0046 16.8 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Thioesterase PF00975.20 CCF37844.1 - 0.0086 16.2 0.1 0.015 15.5 0.1 1.4 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_8 PF06259.12 CCF37844.1 - 0.018 14.7 0.0 0.036 13.7 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase Fungal_trans PF04082.18 CCF37845.1 - 4.7e-10 39.0 0.0 7.6e-10 38.3 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF37845.1 - 0.0035 17.4 10.5 0.0076 16.3 10.5 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain adh_short PF00106.25 CCF37846.1 - 3e-22 79.1 0.0 4.6e-22 78.4 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF37846.1 - 1.4e-15 57.5 0.0 5.9e-15 55.5 0.0 1.8 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase HCO3_cotransp PF00955.21 CCF37847.1 - 1.7e-72 244.9 9.9 3.2e-41 141.7 0.0 2.1 1 1 1 2 2 2 2 HCO3- transporter family BPL_LplA_LipB PF03099.19 CCF37848.1 - 0.0011 18.9 0.0 0.0017 18.2 0.0 1.3 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family Phytase PF02333.15 CCF37848.1 - 0.23 10.4 0.0 0.31 9.9 0.0 1.1 1 0 0 1 1 1 0 Phytase Peptidase_C65 PF10275.9 CCF37849.1 - 3.7e-38 131.4 0.0 4.9e-38 131.0 0.0 1.1 1 0 0 1 1 1 1 Peptidase C65 Otubain ABC_membrane PF00664.23 CCF37850.1 - 2.6e-38 132.2 28.1 2.5e-19 70.0 11.1 3.3 3 0 0 3 3 3 2 ABC transporter transmembrane region ABC_tran PF00005.27 CCF37850.1 - 1.1e-37 129.6 0.0 4.6e-18 66.1 0.0 2.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 CCF37850.1 - 3e-08 33.4 1.7 0.0074 15.7 0.0 3.3 2 1 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CCF37850.1 - 5.1e-08 33.6 0.5 0.00032 21.3 0.1 2.6 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.6 CCF37850.1 - 5.8e-07 29.2 2.0 0.016 15.0 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_25 PF13481.6 CCF37850.1 - 6.4e-07 29.1 0.2 0.027 14.0 0.0 3.0 3 0 0 3 3 3 2 AAA domain AAA_21 PF13304.6 CCF37850.1 - 3.3e-06 27.1 0.9 0.23 11.2 0.3 3.3 2 1 1 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 CCF37850.1 - 9.6e-06 26.1 0.1 0.063 13.6 0.0 2.9 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 CCF37850.1 - 2.4e-05 24.3 0.1 0.075 12.9 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 CCF37850.1 - 0.00017 21.9 0.2 0.61 10.4 0.0 2.7 2 0 0 2 2 2 2 AAA domain T2SSE PF00437.20 CCF37850.1 - 0.0002 20.5 0.5 0.037 13.1 0.2 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein MMR_HSR1 PF01926.23 CCF37850.1 - 0.00056 20.0 0.5 0.034 14.2 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase Viral_helicase1 PF01443.18 CCF37850.1 - 0.0018 18.0 0.1 0.62 9.8 0.0 2.3 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase NACHT PF05729.12 CCF37850.1 - 0.0022 17.9 0.2 2.8 7.8 0.0 2.5 2 0 0 2 2 2 2 NACHT domain FtsK_SpoIIIE PF01580.18 CCF37850.1 - 0.0023 17.3 0.1 0.35 10.2 0.0 2.4 2 0 0 2 2 2 1 FtsK/SpoIIIE family cobW PF02492.19 CCF37850.1 - 0.003 17.2 2.0 0.77 9.3 0.9 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain DUF87 PF01935.17 CCF37850.1 - 0.0035 17.5 0.0 0.0035 17.5 0.0 2.1 2 0 0 2 2 2 1 Helicase HerA, central domain NB-ARC PF00931.22 CCF37850.1 - 0.004 16.4 1.3 2.6 7.2 0.1 3.1 3 0 0 3 3 3 1 NB-ARC domain AAA_30 PF13604.6 CCF37850.1 - 0.0045 16.7 0.1 0.37 10.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain Pox_A32 PF04665.12 CCF37850.1 - 0.0083 15.6 3.0 0.31 10.5 0.1 2.3 2 0 0 2 2 2 1 Poxvirus A32 protein Dynamin_N PF00350.23 CCF37850.1 - 0.019 15.0 1.2 3.6 7.6 0.2 2.4 2 0 0 2 2 2 0 Dynamin family AAA_33 PF13671.6 CCF37850.1 - 0.03 14.5 2.1 6.6 6.9 0.0 2.8 3 0 0 3 3 2 0 AAA domain AAA_28 PF13521.6 CCF37850.1 - 0.032 14.5 0.3 2.7 8.2 0.0 2.7 2 0 0 2 2 2 0 AAA domain Septin PF00735.18 CCF37850.1 - 0.033 13.5 0.1 5.7 6.1 0.0 2.2 2 0 0 2 2 2 0 Septin MobB PF03205.14 CCF37850.1 - 0.035 14.0 0.5 2.7 7.9 0.0 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B CbiA PF01656.23 CCF37850.1 - 0.043 13.9 0.5 2.8 8.0 0.0 2.8 2 1 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain NTPase_1 PF03266.15 CCF37850.1 - 0.044 13.7 1.7 6.4 6.7 0.0 2.4 2 0 0 2 2 2 0 NTPase AAA_15 PF13175.6 CCF37850.1 - 0.051 13.3 1.3 1 9.0 0.2 2.1 2 0 0 2 2 2 0 AAA ATPase domain Roc PF08477.13 CCF37850.1 - 0.052 13.8 0.3 14 5.9 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase DEAD PF00270.29 CCF37850.1 - 0.063 13.0 0.0 18 5.0 0.0 2.7 2 0 0 2 2 2 0 DEAD/DEAH box helicase AAA_18 PF13238.6 CCF37850.1 - 0.067 13.7 0.0 21 5.7 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 CCF37850.1 - 0.1 12.1 0.5 1.8 8.1 0.1 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region DUF2075 PF09848.9 CCF37850.1 - 0.1 11.8 0.3 1 8.5 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_14 PF13173.6 CCF37850.1 - 0.12 12.4 0.1 12 6.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain SbcCD_C PF13558.6 CCF37850.1 - 0.14 12.4 0.0 0.44 10.8 0.0 1.8 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_24 PF13479.6 CCF37850.1 - 0.17 11.6 0.4 8.6 6.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain ATP_bind_1 PF03029.17 CCF37850.1 - 0.75 9.5 2.4 7.3 6.3 0.1 2.3 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Profilin PF00235.19 CCF37851.1 - 1.1e-43 148.5 2.1 1.2e-43 148.3 2.1 1.0 1 0 0 1 1 1 1 Profilin Got1 PF04178.12 CCF37852.1 - 3.4e-15 56.5 11.8 4.2e-15 56.2 11.8 1.1 1 0 0 1 1 1 1 Got1/Sft2-like family YL1_C PF08265.11 CCF37853.1 - 1.1e-15 57.0 0.2 1.9e-15 56.3 0.2 1.4 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain tRNA-synt_1d PF00750.19 CCF37854.1 - 1.2e-65 221.8 0.1 1.7e-65 221.3 0.1 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 CCF37854.1 - 4.1e-14 52.8 0.0 9.4e-14 51.6 0.0 1.7 1 0 0 1 1 1 1 DALR anticodon binding domain Homeodomain PF00046.29 CCF37857.1 - 6.2e-20 70.8 4.5 1.3e-19 69.8 4.5 1.6 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 CCF37857.1 - 0.0016 18.3 0.5 0.0047 16.8 0.5 1.8 1 0 0 1 1 1 1 Homeobox KN domain Hamartin PF04388.12 CCF37857.1 - 0.13 10.9 5.0 0.21 10.2 5.0 1.2 1 0 0 1 1 1 0 Hamartin protein NAM-associated PF14303.6 CCF37857.1 - 1 10.1 8.4 1.6 9.4 8.4 1.3 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain DUF1180 PF06679.12 CCF37857.1 - 9.6 6.6 8.1 35 4.8 8.1 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) SAD_SRA PF02182.17 CCF37859.1 - 2.8e-37 127.8 0.5 4e-37 127.3 0.0 1.5 2 0 0 2 2 2 1 SAD/SRA domain Ribonuclease PF00545.20 CCF37859.1 - 0.045 14.5 0.1 12 6.7 0.0 2.6 2 0 0 2 2 2 0 ribonuclease Orn_Arg_deC_N PF02784.16 CCF37860.1 - 6.8e-84 281.1 0.0 1.1e-83 280.5 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 CCF37860.1 - 3.3e-19 68.9 0.1 1.2e-18 67.2 0.0 1.8 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Bul1_C PF04426.12 CCF37861.1 - 0.00035 20.1 0.0 0.00047 19.7 0.0 1.2 1 0 0 1 1 1 1 Bul1 C terminus FAD_binding_4 PF01565.23 CCF37862.1 - 6.6e-21 74.5 5.7 1.1e-20 73.8 5.7 1.3 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 CCF37862.1 - 2.7e-07 30.6 0.0 5.3e-07 29.6 0.0 1.5 1 0 0 1 1 1 1 Berberine and berberine like Bac_surface_Ag PF01103.23 CCF37863.1 - 6.1e-39 134.4 0.6 8.4e-39 133.9 0.6 1.2 1 0 0 1 1 1 1 Surface antigen TB2_DP1_HVA22 PF03134.19 CCF37864.1 - 1.4e-22 79.4 9.6 2.3e-22 78.7 9.6 1.3 1 0 0 1 1 1 1 TB2/DP1, HVA22 family RFX_DNA_binding PF02257.15 CCF37865.1 - 2e-27 95.6 0.1 4.8e-27 94.4 0.1 1.6 1 0 0 1 1 1 1 RFX DNA-binding domain FMN_dh PF01070.18 CCF37866.1 - 7.1e-87 291.7 0.3 7.2e-48 163.4 0.1 2.1 1 1 1 2 2 2 2 FMN-dependent dehydrogenase IMPDH PF00478.25 CCF37866.1 - 0.0014 17.7 0.1 0.0029 16.6 0.1 1.7 2 0 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.17 CCF37866.1 - 0.0053 15.9 0.0 0.0086 15.3 0.0 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase Peptidase_M19 PF01244.21 CCF37866.1 - 0.0061 15.8 0.0 0.017 14.3 0.0 1.7 2 0 0 2 2 2 1 Membrane dipeptidase (Peptidase family M19) His_biosynth PF00977.21 CCF37866.1 - 0.065 12.7 0.2 0.6 9.5 0.2 2.4 1 1 0 1 1 1 0 Histidine biosynthesis protein Ino80_Iec3 PF14612.6 CCF37867.1 - 9.8e-27 95.1 4.1 1.3e-24 88.2 0.2 2.6 2 1 1 3 3 3 2 IEC3 subunit of the Ino80 complex, chromatin re-modelling Iso_dh PF00180.20 CCF37868.1 - 1.7e-73 247.8 0.0 2e-73 247.5 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase AAA PF00004.29 CCF37869.1 - 5.7e-15 55.9 0.0 1.4e-14 54.7 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) TFIIF_alpha PF05793.12 CCF37869.1 - 0.00044 19.0 32.5 0.00044 19.0 32.5 2.6 3 0 0 3 3 3 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) AAA_22 PF13401.6 CCF37869.1 - 0.0047 17.2 3.4 0.15 12.3 0.1 3.1 2 1 1 3 3 3 1 AAA domain AAA_5 PF07728.14 CCF37869.1 - 0.01 15.9 0.0 0.033 14.2 0.0 1.9 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CCF37869.1 - 0.041 14.3 0.3 0.18 12.2 0.3 2.1 1 1 0 1 1 1 0 AAA ATPase domain AAA_11 PF13086.6 CCF37869.1 - 0.043 13.6 16.5 0.15 11.8 0.0 3.8 4 0 0 4 4 4 0 AAA domain AAA_18 PF13238.6 CCF37869.1 - 0.091 13.3 2.1 0.1 13.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain Apt1 PF10351.9 CCF37869.1 - 0.67 8.7 21.7 1.7 7.4 21.7 1.8 1 0 0 1 1 1 0 Golgi-body localisation protein domain Mg_chelatase PF01078.21 CCF37869.1 - 0.68 9.3 2.7 0.55 9.6 0.2 2.1 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Hamartin PF04388.12 CCF37869.1 - 1.8 7.1 18.8 2.7 6.5 18.8 1.2 1 0 0 1 1 1 0 Hamartin protein FAD_binding_4 PF01565.23 CCF37870.1 - 2.5e-23 82.3 3.7 4.6e-23 81.5 2.6 1.9 1 1 1 2 2 2 1 FAD binding domain BBE PF08031.12 CCF37870.1 - 8.9e-08 32.1 0.4 1.9e-07 31.1 0.4 1.5 1 0 0 1 1 1 1 Berberine and berberine like MFS_1 PF07690.16 CCF37872.1 - 3.6e-35 121.5 60.5 8.3e-25 87.5 33.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Glyco_hydro_92 PF07971.12 CCF37873.1 - 1.7e-144 482.2 1.0 2.2e-144 481.9 1.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 CCF37873.1 - 1.1e-54 185.9 1.4 1.1e-54 185.9 1.4 1.5 2 0 0 2 2 2 1 Glycosyl hydrolase family 92 N-terminal domain MFS_1 PF07690.16 CCF37874.1 - 1.5e-17 63.6 13.7 2.4e-17 62.9 13.7 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily TMEM132D_C PF15706.5 CCF37874.1 - 0.036 13.8 0.6 0.067 13.0 0.0 1.7 2 0 0 2 2 2 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term NAD_binding_2 PF03446.15 CCF37875.1 - 3.7e-22 79.2 0.2 5.8e-22 78.6 0.2 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 CCF37875.1 - 3.3e-09 37.0 0.2 8.4e-09 35.7 0.0 1.7 2 0 0 2 2 2 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase CbbQ_C PF08406.10 CCF37875.1 - 0.018 15.3 0.3 0.16 12.2 0.1 2.3 2 0 0 2 2 2 0 CbbQ/NirQ/NorQ C-terminal Inhibitor_I9 PF05922.16 CCF37876.1 - 7.5e-13 49.0 0.0 1.3e-12 48.2 0.0 1.4 1 0 0 1 1 1 1 Peptidase inhibitor I9 Peptidase_S8 PF00082.22 CCF37876.1 - 3.9e-09 36.2 0.1 1.1e-08 34.7 0.1 1.8 1 1 0 1 1 1 1 Subtilase family DUF1314 PF07013.11 CCF37876.1 - 0.034 14.0 0.0 0.07 13.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1314) RAP1 PF07218.11 CCF37877.1 - 0.0086 14.4 1.0 0.012 13.9 1.0 1.1 1 0 0 1 1 1 1 Rhoptry-associated protein 1 (RAP-1) MCLC PF05934.11 CCF37877.1 - 0.14 10.9 0.7 0.18 10.5 0.7 1.1 1 0 0 1 1 1 0 Mid-1-related chloride channel (MCLC) Fungal_trans PF04082.18 CCF37878.1 - 1.3e-09 37.4 0.0 2e-09 36.9 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF37878.1 - 3.8e-08 33.3 7.5 5.9e-08 32.7 7.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pkinase PF00069.25 CCF37879.1 - 1.6e-19 70.4 0.0 7.1e-11 42.0 0.0 2.9 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCF37879.1 - 8.5e-08 31.8 0.1 0.0064 15.8 0.0 3.3 3 1 0 3 3 3 2 Protein tyrosine kinase p450 PF00067.22 CCF37880.1 - 0.0057 15.4 0.0 0.0069 15.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Methyltransf_23 PF13489.6 CCF37882.1 - 7.9e-17 61.6 0.0 1.3e-16 60.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF37882.1 - 3.3e-05 24.6 0.0 0.00011 22.8 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF37882.1 - 5.4e-05 23.8 0.0 0.37 11.5 0.0 3.3 2 1 1 3 3 3 2 Methyltransferase domain Methyltransf_11 PF08241.12 CCF37882.1 - 7.1e-05 23.4 0.0 0.0066 17.1 0.0 2.7 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF37882.1 - 0.009 15.8 0.0 0.15 11.9 0.0 2.4 3 0 0 3 3 3 1 Methyltransferase domain UPF0029 PF01205.19 CCF37883.1 - 3.5e-25 88.4 0.0 1.1e-24 86.8 0.0 1.9 2 0 0 2 2 2 1 Uncharacterized protein family UPF0029 TrkH PF02386.16 CCF37884.1 - 2.3e-142 475.0 10.8 1.3e-141 472.5 6.2 2.1 2 0 0 2 2 2 2 Cation transport protein HCO3_cotransp PF00955.21 CCF37885.1 - 2.2e-84 284.1 11.9 1.2e-45 156.3 5.9 2.0 1 1 1 2 2 2 2 HCO3- transporter family Zn_clus PF00172.18 CCF37886.1 - 5.6e-07 29.6 7.5 8.1e-07 29.1 7.5 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_transf_90 PF05686.12 CCF37887.1 - 2.2e-19 69.6 0.0 1.6e-15 56.9 0.0 2.2 2 0 0 2 2 2 2 Glycosyl transferase family 90 DUF2779 PF11074.8 CCF37887.1 - 0.057 13.9 0.0 0.12 12.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function(DUF2779) Fungal_trans PF04082.18 CCF37889.1 - 2.5e-12 46.4 0.0 5.8e-12 45.2 0.0 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain SPX PF03105.19 CCF37889.1 - 3.3 7.5 7.4 5 6.9 7.4 1.2 1 0 0 1 1 1 0 SPX domain Ribosomal_60s PF00428.19 CCF37890.1 - 2e-17 63.5 3.5 2.5e-17 63.2 3.5 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein MutS_V PF00488.21 CCF37891.1 - 9.6e-69 231.2 0.0 2.4e-68 229.9 0.0 1.7 2 0 0 2 2 2 1 MutS domain V MutS_III PF05192.18 CCF37891.1 - 8.1e-44 150.1 5.0 1.4e-43 149.4 5.0 1.4 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.20 CCF37891.1 - 9.5e-18 64.5 0.0 2.1e-17 63.4 0.0 1.6 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.17 CCF37891.1 - 1.2e-06 28.9 0.0 2.8e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 MutS domain II AAA_29 PF13555.6 CCF37891.1 - 0.081 12.7 0.0 0.19 11.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Thioredoxin_12 PF18400.1 CCF37892.1 - 0.1 12.4 0.7 0.19 11.6 0.7 1.4 1 0 0 1 1 1 0 Thioredoxin-like domain Astro_capsid_p PF12226.8 CCF37892.1 - 1.5 7.9 10.4 1.6 7.8 9.7 1.3 1 1 0 1 1 1 0 Turkey astrovirus capsid protein GET2 PF08690.10 CCF37892.1 - 8.2 6.0 9.2 3.6 7.2 4.8 2.2 2 0 0 2 2 2 0 GET complex subunit GET2 Glyco_hydro_38N PF01074.22 CCF37893.1 - 1e-88 297.5 1.4 1.5e-88 296.9 1.4 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 CCF37893.1 - 1.4e-54 185.4 0.3 1.2e-53 182.4 0.1 2.1 2 0 0 2 2 2 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 CCF37893.1 - 5.3e-28 97.0 0.0 1.1e-27 96.0 0.0 1.6 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro38C2 PF17677.1 CCF37893.1 - 2.4e-11 43.6 0.0 1.1e-10 41.5 0.0 2.1 1 1 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain Pkinase PF00069.25 CCF37894.1 - 2.5e-20 73.0 0.0 4.3e-20 72.2 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF37894.1 - 3.8e-07 29.6 0.0 0.00022 20.6 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 CCF37894.1 - 0.063 13.2 0.0 0.14 12.1 0.0 1.5 2 0 0 2 2 2 0 Phosphotransferase enzyme family Aldedh PF00171.22 CCF37895.1 - 3.2e-83 279.8 0.0 3.8e-83 279.5 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DEAD PF00270.29 CCF37899.1 - 2.5e-19 69.7 0.0 3.3e-19 69.3 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 CCF37899.1 - 0.0019 18.2 0.0 0.0034 17.4 0.0 1.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF4636 PF15468.6 CCF37899.1 - 0.12 12.1 0.8 0.2 11.3 0.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4636) NACHT PF05729.12 CCF37900.1 - 5.9e-12 45.8 0.0 9.8e-12 45.1 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 CCF37900.1 - 1.2e-08 35.6 0.3 2.6e-08 34.5 0.1 1.6 2 0 0 2 2 2 1 AAA ATPase domain PNP_UDP_1 PF01048.20 CCF37900.1 - 1.3e-07 31.2 0.4 4.8e-07 29.3 0.4 1.8 1 1 0 1 1 1 1 Phosphorylase superfamily AAA_22 PF13401.6 CCF37900.1 - 2.5e-06 27.8 0.0 8.1e-06 26.1 0.0 1.8 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.22 CCF37900.1 - 0.0023 17.1 0.2 0.0079 15.4 0.2 1.8 1 1 0 1 1 1 1 NB-ARC domain ABC_tran PF00005.27 CCF37900.1 - 0.061 13.8 0.0 0.78 10.2 0.0 2.3 2 0 0 2 2 2 0 ABC transporter ATPase_2 PF01637.18 CCF37900.1 - 0.12 12.3 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 CCF37900.1 - 0.15 12.4 0.0 0.47 10.9 0.0 1.9 1 0 0 1 1 1 0 RNA helicase AAA_7 PF12775.7 CCF37900.1 - 0.17 11.4 0.0 0.32 10.5 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region TCTP PF00838.17 CCF37901.1 - 1.7e-69 233.4 1.5 1.9e-69 233.3 1.5 1.0 1 0 0 1 1 1 1 Translationally controlled tumour protein Ribosomal_L14 PF00238.19 CCF37903.1 - 9.7e-33 112.8 0.0 1.2e-32 112.6 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e MFS_1 PF07690.16 CCF37904.1 - 1.3e-22 80.2 20.5 1.3e-22 80.2 20.5 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.6 CCF37904.1 - 7.5e-11 41.2 15.5 0.00043 19.0 1.0 3.1 3 0 0 3 3 3 3 MFS/sugar transport protein MFS_1_like PF12832.7 CCF37904.1 - 1.7e-07 30.5 13.4 4.9e-05 22.4 4.0 2.6 2 1 0 2 2 2 2 MFS_1 like family Sugar_tr PF00083.24 CCF37904.1 - 8.5e-06 24.9 6.2 1.4e-05 24.2 6.2 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter TRI12 PF06609.13 CCF37904.1 - 0.0026 16.3 2.9 0.0028 16.1 2.0 1.4 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Tom22 PF04281.13 CCF37904.1 - 0.024 14.4 0.0 0.24 11.2 0.0 2.3 2 0 0 2 2 2 0 Mitochondrial import receptor subunit Tom22 Nuc_H_symport PF03825.16 CCF37904.1 - 0.25 10.3 9.7 0.93 8.4 9.7 1.8 1 1 0 1 1 1 0 Nucleoside H+ symporter RexB PF15968.5 CCF37904.1 - 0.47 10.9 4.7 0.18 12.2 1.4 2.0 2 0 0 2 2 2 0 Membrane-anchored ion channel, Abi component DUF1761 PF08570.10 CCF37904.1 - 0.91 9.8 8.3 0.17 12.2 1.5 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1761) adh_short PF00106.25 CCF37905.1 - 5.8e-44 149.9 0.0 9.7e-44 149.2 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF37905.1 - 4.8e-32 111.4 0.0 5.9e-32 111.1 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF37905.1 - 4.6e-10 39.7 0.0 6.9e-10 39.1 0.0 1.3 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 CCF37905.1 - 2.9e-06 26.9 0.0 4.9e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) NAD_binding_10 PF13460.6 CCF37905.1 - 1.4e-05 25.1 0.0 3.5e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 NAD(P)H-binding ADH_zinc_N PF00107.26 CCF37905.1 - 0.0009 19.2 0.0 0.0026 17.7 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Epimerase PF01370.21 CCF37905.1 - 0.0017 17.9 0.2 0.011 15.3 0.1 2.2 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 CCF37905.1 - 0.015 14.4 0.1 0.03 13.4 0.0 1.5 2 0 0 2 2 2 0 RmlD substrate binding domain 2-Hacid_dh_C PF02826.19 CCF37905.1 - 0.026 13.9 0.0 0.06 12.7 0.0 1.6 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NmrA PF05368.13 CCF37905.1 - 0.052 13.1 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 NmrA-like family TrkA_N PF02254.18 CCF37905.1 - 0.11 12.8 0.0 0.21 11.9 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain Ecm29 PF13001.7 CCF37908.1 - 3.4e-106 355.9 0.0 9.8e-105 351.1 0.0 2.6 2 0 0 2 2 2 1 Proteasome stabiliser HEAT PF02985.22 CCF37908.1 - 0.00016 21.7 8.0 3.4 8.2 0.0 6.7 8 0 0 8 8 8 2 HEAT repeat IFRD PF05004.13 CCF37908.1 - 0.041 13.0 0.0 0.89 8.6 0.0 3.0 4 0 0 4 4 4 0 Interferon-related developmental regulator (IFRD) MFS_1 PF07690.16 CCF37910.1 - 6.2e-23 81.3 22.6 6.2e-23 81.3 22.6 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF37910.1 - 0.00027 19.9 36.4 0.023 13.6 36.2 3.0 1 1 0 1 1 1 1 Sugar (and other) transporter DUF5336 PF17270.2 CCF37910.1 - 0.26 10.9 0.0 0.26 10.9 0.0 3.3 4 0 0 4 4 4 0 Family of unknown function (DUF5336) OATP PF03137.20 CCF37910.1 - 0.32 9.2 9.4 0.12 10.6 1.9 2.3 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Lyase_1 PF00206.20 CCF37911.1 - 1.1e-25 90.7 0.2 1.8e-25 90.0 0.2 1.3 1 0 0 1 1 1 1 Lyase ASL_C2 PF14698.6 CCF37911.1 - 5.8e-12 46.2 0.0 1.7e-11 44.7 0.0 1.9 1 0 0 1 1 1 1 Argininosuccinate lyase C-terminal Pup_ligase PF03136.15 CCF37911.1 - 0.026 13.5 0.0 0.046 12.7 0.0 1.4 1 0 0 1 1 1 0 Pup-ligase protein CSS-motif PF12792.7 CCF37911.1 - 0.11 12.0 1.1 0.81 9.1 0.1 2.1 2 0 0 2 2 2 0 CSS motif domain associated with EAL Abhydrolase_3 PF07859.13 CCF37912.1 - 0.00049 20.0 0.1 0.0015 18.5 0.0 1.7 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_1 PF00561.20 CCF37912.1 - 0.001 18.8 0.1 0.66 9.6 0.0 2.5 2 1 0 3 3 3 2 alpha/beta hydrolase fold Esterase PF00756.20 CCF37912.1 - 0.0048 16.6 0.1 0.008 15.8 0.1 1.3 1 0 0 1 1 1 1 Putative esterase Abhydrolase_6 PF12697.7 CCF37912.1 - 0.0049 17.5 1.3 0.0062 17.2 1.3 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Lipase_3 PF01764.25 CCF37912.1 - 0.0095 15.8 0.0 0.017 15.0 0.0 1.5 1 1 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 CCF37912.1 - 0.021 14.1 0.0 0.045 13.0 0.0 1.6 1 1 0 1 1 1 0 Serine aminopeptidase, S33 DUF915 PF06028.11 CCF37912.1 - 0.024 13.9 0.0 0.035 13.4 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) Thioesterase PF00975.20 CCF37912.1 - 0.13 12.4 0.1 0.32 11.1 0.1 1.6 1 1 1 2 2 2 0 Thioesterase domain Exo_endo_phos PF03372.23 CCF37913.1 - 8.1e-08 32.1 0.2 1.5e-07 31.2 0.2 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family NB-ARC PF00931.22 CCF37913.1 - 0.018 14.3 0.0 0.031 13.5 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain FANCI_HD1 PF14679.6 CCF37915.1 - 0.095 12.7 0.1 0.16 12.0 0.1 1.5 1 1 0 1 1 1 0 FANCI helical domain 1 Sec7 PF01369.20 CCF37916.1 - 1.1e-73 246.9 6.2 7.6e-73 244.1 1.0 3.1 3 0 0 3 3 3 2 Sec7 domain DUF1981 PF09324.10 CCF37916.1 - 7.6e-34 115.4 12.7 1.1e-32 111.7 0.3 5.3 6 0 0 6 6 6 2 Domain of unknown function (DUF1981) Methyltransf_25 PF13649.6 CCF37917.1 - 1.5e-18 67.3 0.0 1.3e-17 64.2 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF37917.1 - 7.1e-15 55.4 0.0 2e-14 54.0 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF37917.1 - 2.5e-10 40.4 0.0 3e-10 40.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF37917.1 - 2.6e-09 37.1 0.0 4.5e-09 36.3 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF37917.1 - 8.4e-08 32.9 0.0 4.2e-07 30.6 0.0 2.2 3 0 0 3 3 3 1 Methyltransferase domain CMAS PF02353.20 CCF37917.1 - 9.4e-06 25.1 0.0 1.1e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase MTS PF05175.14 CCF37917.1 - 0.011 15.3 0.0 0.018 14.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Pox_MCEL PF03291.16 CCF37917.1 - 0.17 11.0 0.0 0.64 9.1 0.0 1.7 1 1 1 2 2 2 0 mRNA capping enzyme Bac_rhodopsin PF01036.18 CCF37918.1 - 1.9e-33 115.9 19.8 2.5e-33 115.5 19.8 1.0 1 0 0 1 1 1 1 Bacteriorhodopsin-like protein MCLC PF05934.11 CCF37918.1 - 0.86 8.3 3.1 1.1 7.9 3.1 1.1 1 0 0 1 1 1 0 Mid-1-related chloride channel (MCLC) Complex1_LYR PF05347.15 CCF37921.1 - 2.9e-18 65.7 2.3 4e-18 65.2 2.3 1.2 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 CCF37921.1 - 7.1e-05 23.5 0.8 8.7e-05 23.2 0.8 1.2 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR_1 PF13232.6 CCF37921.1 - 0.06 13.9 0.2 0.082 13.5 0.2 1.2 1 0 0 1 1 1 0 Complex1_LYR-like KR PF08659.10 CCF37923.1 - 5.1e-54 182.9 0.3 1e-52 178.7 0.1 2.8 3 0 0 3 3 3 1 KR domain Methyltransf_23 PF13489.6 CCF37923.1 - 2.7e-18 66.3 0.0 6.4e-18 65.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF37923.1 - 3.9e-18 66.0 0.0 1.5e-17 64.1 0.0 2.2 1 0 0 1 1 1 1 Methyltransferase domain adh_short PF00106.25 CCF37923.1 - 2.1e-15 56.7 0.1 5.6e-15 55.3 0.1 1.7 1 0 0 1 1 1 1 short chain dehydrogenase Methyltransf_25 PF13649.6 CCF37923.1 - 8e-14 52.1 0.1 8.1e-13 48.9 0.0 2.8 3 0 0 3 3 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF37923.1 - 8.1e-13 48.4 0.0 1.9e-12 47.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF37923.1 - 1.1e-12 48.5 0.0 4.4e-12 46.5 0.0 2.2 1 0 0 1 1 1 1 Methyltransferase domain Condensation PF00668.20 CCF37923.1 - 9.7e-11 41.0 0.0 1.5e-10 40.4 0.0 1.2 1 0 0 1 1 1 1 Condensation domain adh_short_C2 PF13561.6 CCF37923.1 - 2.5e-06 27.2 0.1 5.8e-06 26.0 0.1 1.6 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Ubie_methyltran PF01209.18 CCF37923.1 - 1.1e-05 25.0 0.0 2.8e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PP-binding PF00550.25 CCF37923.1 - 2.9e-05 24.3 0.1 6.8e-05 23.1 0.1 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site Methyltransf_16 PF10294.9 CCF37923.1 - 0.00014 21.6 0.0 0.00028 20.7 0.0 1.4 1 0 0 1 1 1 1 Lysine methyltransferase N2227 PF07942.12 CCF37923.1 - 0.01 15.1 0.3 0.13 11.4 0.0 2.3 2 0 0 2 2 2 0 N2227-like protein Methyltransf_33 PF10017.9 CCF37923.1 - 0.034 13.3 0.0 0.077 12.1 0.0 1.5 1 0 0 1 1 1 0 Histidine-specific methyltransferase, SAM-dependent PCMT PF01135.19 CCF37923.1 - 0.038 13.8 0.0 0.088 12.5 0.0 1.6 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DREV PF05219.12 CCF37923.1 - 0.054 12.6 0.0 0.12 11.4 0.0 1.5 1 0 0 1 1 1 0 DREV methyltransferase DPPIV_N PF00930.21 CCF37924.1 - 7.7e-110 367.0 0.1 1.1e-109 366.5 0.1 1.2 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 CCF37924.1 - 3.1e-38 131.4 0.2 5.1e-38 130.7 0.2 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 CCF37924.1 - 0.00012 22.8 0.8 0.00048 20.8 0.1 2.4 3 0 0 3 3 3 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCF37924.1 - 0.016 14.5 0.1 0.054 12.8 0.0 1.9 3 0 0 3 3 3 0 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 CCF37924.1 - 0.088 12.7 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold RNA_pol_Rpb6 PF01192.22 CCF37926.1 - 3.5e-17 62.0 0.7 6.7e-17 61.2 0.2 1.7 2 0 0 2 2 2 1 RNA polymerase Rpb6 zf-C2H2 PF00096.26 CCF37927.1 - 2.9e-29 99.8 50.7 5.5e-05 23.4 0.7 10.4 10 0 0 10 10 10 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCF37927.1 - 6.2e-20 70.2 54.5 0.048 14.5 0.6 10.9 10 1 0 10 10 10 9 C2H2-type zinc finger FOXP-CC PF16159.5 CCF37927.1 - 1.4e-11 44.8 26.4 0.086 13.5 0.5 7.7 3 1 5 8 8 8 5 FOXP coiled-coil domain zf-H2C2_2 PF13465.6 CCF37927.1 - 2.6e-09 37.1 54.0 0.00077 19.8 1.5 11.0 11 1 0 11 11 11 4 Zinc-finger double domain zf-C2H2_jaz PF12171.8 CCF37927.1 - 1.1e-06 28.7 24.9 0.58 10.5 0.0 8.9 11 0 0 11 11 11 3 Zinc-finger double-stranded RNA-binding zf-C2H2_8 PF15909.5 CCF37927.1 - 2.8e-05 24.3 17.5 0.063 13.6 5.6 5.0 3 1 2 5 5 5 3 C2H2-type zinc ribbon zf-met PF12874.7 CCF37927.1 - 5.4e-05 23.4 15.5 0.032 14.6 0.0 7.4 8 0 0 8 8 8 2 Zinc-finger of C2H2 type zf-C2H2_aberr PF17017.5 CCF37927.1 - 0.0032 17.6 15.0 2.6 8.2 0.3 5.7 3 1 3 6 6 6 1 Aberrant zinc-finger DUF4187 PF13821.6 CCF37927.1 - 0.0034 17.1 2.0 0.02 14.7 0.4 2.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4187) zf-C2H2_6 PF13912.6 CCF37927.1 - 1.1 9.3 0.0 1.1 9.3 0.0 5.5 6 0 0 6 6 6 0 C2H2-type zinc finger Zip PF02535.22 CCF37928.1 - 2.6e-08 33.5 7.3 3.2e-08 33.2 2.1 2.0 1 1 1 2 2 2 2 ZIP Zinc transporter Inhibitor_I9 PF05922.16 CCF37929.1 - 1.7e-21 76.7 0.7 1.7e-21 76.7 0.7 1.6 2 0 0 2 2 2 1 Peptidase inhibitor I9 Peptidase_S8 PF00082.22 CCF37929.1 - 1.1e-05 24.8 7.8 1.6e-05 24.3 7.8 1.5 1 1 0 1 1 1 1 Subtilase family Aldo_ket_red PF00248.21 CCF37930.1 - 1.6e-71 240.9 0.0 1.9e-71 240.6 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family DUF5543 PF17697.1 CCF37931.1 - 0.14 12.4 2.4 0.12 12.7 0.6 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5543) TFIIA PF03153.13 CCF37932.1 - 2.9e-89 301.0 13.5 4.6e-89 300.3 13.5 1.3 1 1 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF3295 PF11702.8 CCF37932.1 - 1.3 8.3 8.7 0.25 10.7 0.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3295) Spt20 PF12090.8 CCF37932.1 - 9.2 5.8 14.4 15 5.1 14.4 1.3 1 0 0 1 1 1 0 Spt20 family ANAPC4_WD40 PF12894.7 CCF37933.1 - 1.6e-17 63.5 5.3 3.4e-05 24.1 0.1 4.3 3 1 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CCF37933.1 - 2e-16 60.1 18.3 0.00033 21.4 0.1 6.5 7 0 0 7 7 7 5 WD domain, G-beta repeat Ge1_WD40 PF16529.5 CCF37933.1 - 2.9e-06 26.5 0.1 0.00034 19.7 0.0 3.3 2 1 1 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 CCF37933.1 - 3.9e-06 26.9 0.2 0.0006 19.8 0.1 2.5 1 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A Kelch_4 PF13418.6 CCF37934.1 - 2.3e-26 91.5 9.6 1.3e-08 34.7 0.0 5.2 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_6 PF13964.6 CCF37934.1 - 2.9e-21 75.0 4.0 7.8e-05 22.8 0.0 5.0 3 1 2 5 5 5 4 Kelch motif Kelch_5 PF13854.6 CCF37934.1 - 3.2e-20 71.7 7.3 1.5e-06 28.0 0.0 5.0 5 0 0 5 5 5 4 Kelch motif Kelch_1 PF01344.25 CCF37934.1 - 2.2e-19 68.8 0.7 0.00012 21.6 0.0 4.9 5 0 0 5 5 5 3 Kelch motif Kelch_3 PF13415.6 CCF37934.1 - 1.3e-17 63.6 2.9 1.2e-06 28.7 0.1 5.2 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_2 PF07646.15 CCF37934.1 - 9.5e-16 57.1 4.3 0.0019 18.1 0.0 4.7 4 0 0 4 4 4 4 Kelch motif BTB PF00651.31 CCF37934.1 - 2.8e-09 37.2 0.0 4.8e-09 36.4 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.15 CCF37934.1 - 0.031 14.4 0.0 0.061 13.4 0.0 1.4 1 0 0 1 1 1 0 BTB And C-terminal Kelch peroxidase PF00141.23 CCF37935.1 - 4.2e-09 36.4 1.1 8.3e-09 35.5 1.1 1.5 1 1 0 1 1 1 1 Peroxidase Mucin PF01456.17 CCF37938.1 - 5.7 6.9 17.1 8 6.5 17.1 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein Ribosomal_L16 PF00252.18 CCF37939.1 - 6.9e-44 149.1 0.0 9.1e-44 148.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e Ribosomal_L7Ae PF01248.26 CCF37940.1 - 1.3e-21 76.2 0.0 1.5e-21 76.0 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family TBP PF00352.21 CCF37941.1 - 9.2e-31 105.6 0.0 3.2e-29 100.7 0.0 2.0 1 1 1 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 CCF37941.1 - 0.0011 19.0 0.0 0.0018 18.4 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3378) Terpene_synth_C PF03936.16 CCF37943.1 - 0.038 13.3 0.2 1.5 8.1 0.0 2.1 2 0 0 2 2 2 0 Terpene synthase family, metal binding domain YhzD PF14120.6 CCF37945.1 - 0.011 15.9 1.0 0.021 14.9 1.0 1.4 1 0 0 1 1 1 0 YhzD-like protein Tyrosinase PF00264.20 CCF37946.1 - 5.4e-38 131.5 5.5 1.4e-37 130.1 5.5 1.6 1 1 0 1 1 1 1 Common central domain of tyrosinase HET PF06985.11 CCF37948.1 - 3.2e-19 69.7 0.0 4.4e-19 69.3 0.0 1.3 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Myb_DNA-binding PF00249.31 CCF37949.1 - 1.5e-17 63.5 1.7 1.6e-09 37.8 0.2 2.1 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CCF37949.1 - 7.8e-11 42.1 0.5 0.00017 21.7 0.0 2.4 1 1 2 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_2 PF08914.11 CCF37949.1 - 0.044 14.0 0.3 0.14 12.4 0.1 2.0 1 1 1 2 2 2 0 Rap1 Myb domain Rod-binding PF10135.9 CCF37949.1 - 0.077 13.6 0.2 0.21 12.2 0.2 1.7 1 1 0 1 1 1 0 Rod binding protein PLA2_B PF01735.18 CCF37950.1 - 2.2e-193 643.2 0.0 2.5e-193 643.0 0.0 1.0 1 0 0 1 1 1 1 Lysophospholipase catalytic domain FAM220 PF15487.6 CCF37951.1 - 2.3 7.8 12.2 4.6 6.8 12.2 1.5 1 0 0 1 1 1 0 FAM220 family Spt20 PF12090.8 CCF37951.1 - 3.6 7.1 24.7 6.7 6.3 24.7 1.4 1 0 0 1 1 1 0 Spt20 family MMR1 PF08505.10 CCF37951.1 - 9.5 6.4 23.0 14 5.8 22.6 1.6 1 1 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein ACBP PF00887.19 CCF37952.1 - 4.7e-12 45.9 0.1 5.3e-12 45.8 0.1 1.1 1 0 0 1 1 1 1 Acyl CoA binding protein Ribonuclease_3 PF00636.26 CCF37953.1 - 2.2e-12 47.5 0.0 7.1e-12 45.9 0.0 1.8 2 0 0 2 2 2 1 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 CCF37953.1 - 5.3e-08 33.1 0.0 1.4e-07 31.8 0.0 1.7 1 0 0 1 1 1 1 Ribonuclease-III-like dsrm PF00035.26 CCF37953.1 - 0.0017 19.0 0.1 0.0042 17.7 0.1 1.8 1 1 0 1 1 1 1 Double-stranded RNA binding motif Staufen_C PF16482.5 CCF37953.1 - 0.16 12.2 0.0 0.33 11.1 0.0 1.5 1 0 0 1 1 1 0 Staufen C-terminal domain MRP-S33 PF08293.11 CCF37954.1 - 7.8e-31 106.2 0.0 9.5e-31 105.9 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit S27 PUF PF00806.19 CCF37955.1 - 5.9e-39 129.6 0.8 2.5e-06 26.9 0.0 8.8 9 0 0 9 9 9 7 Pumilio-family RNA binding repeat RasGEF PF00617.19 CCF37955.1 - 0.067 13.4 0.2 0.38 10.9 0.0 2.3 2 0 0 2 2 2 0 RasGEF domain DUF5572 PF17733.1 CCF37956.1 - 4.2e-18 64.9 0.4 8e-18 64.0 0.4 1.5 1 0 0 1 1 1 1 Family of unknown function (DUF5572) Pribosyl_synth PF14572.6 CCF37957.1 - 7.3e-42 143.5 1.6 2.4e-36 125.5 0.4 2.3 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.6 CCF37957.1 - 5e-32 110.3 0.0 1.2e-31 109.1 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.27 CCF37957.1 - 3.6e-18 65.6 0.2 8e-18 64.5 0.2 1.5 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 CCF37957.1 - 0.0011 18.5 0.1 0.0018 17.8 0.1 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRTase_2 PF15609.6 CCF37957.1 - 0.15 11.5 0.1 0.26 10.8 0.1 1.3 1 0 0 1 1 1 0 Phosphoribosyl transferase Beta-lactamase PF00144.24 CCF37958.1 - 8.4e-32 110.7 0.0 1.2e-31 110.2 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase BTRD1 PF17660.1 CCF37958.1 - 3.2e-14 52.4 1.2 8.4e-06 25.5 0.1 3.7 4 0 0 4 4 4 2 Bacterial tandem repeat domain 1 DUF3533 PF12051.8 CCF37958.1 - 0.036 13.0 0.1 0.05 12.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) BRF1 PF07741.13 CCF37960.1 - 0.076 13.4 0.5 0.081 13.3 0.5 1.1 1 0 0 1 1 1 0 Brf1-like TBP-binding domain Spore_coat_CotO PF14153.6 CCF37960.1 - 0.14 12.1 5.2 0.16 11.9 5.2 1.1 1 0 0 1 1 1 0 Spore coat protein CotO DUF2968 PF11180.8 CCF37960.1 - 0.25 11.0 10.7 0.29 10.8 10.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) Spt20 PF12090.8 CCF37960.1 - 1.4 8.5 11.6 1.6 8.3 11.6 1.1 1 0 0 1 1 1 0 Spt20 family Presenilin PF01080.17 CCF37960.1 - 4.2 6.0 4.3 4.2 6.0 4.3 1.0 1 0 0 1 1 1 0 Presenilin DDE_1 PF03184.19 CCF37961.1 - 1.2e-14 54.4 0.0 1.4e-14 54.1 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease CCDC14 PF15254.6 CCF37962.1 - 0.027 13.1 0.1 0.027 13.1 0.1 1.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 14 SR-25 PF10500.9 CCF37963.1 - 6.5 6.3 21.9 8.5 5.9 21.9 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DLH PF01738.18 CCF37964.1 - 1e-15 57.9 0.0 1.5e-15 57.4 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family adh_short PF00106.25 CCF37965.1 - 3.9e-47 160.2 0.5 5.1e-47 159.9 0.5 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF37965.1 - 7.4e-35 120.6 0.2 9.1e-35 120.3 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF37965.1 - 6.5e-11 42.5 0.2 1.2e-10 41.6 0.2 1.3 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 CCF37965.1 - 7e-05 22.1 0.3 0.00014 21.1 0.3 1.6 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 CCF37965.1 - 0.00028 20.4 0.6 0.016 14.7 0.2 2.4 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CCF37965.1 - 0.0011 18.9 0.3 0.0042 17.0 0.3 1.9 1 1 0 1 1 1 1 NAD(P)H-binding F420_oxidored PF03807.17 CCF37965.1 - 0.0024 18.4 0.2 0.012 16.2 0.1 2.0 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 CCF37965.1 - 0.0038 17.3 0.1 0.0089 16.1 0.1 1.7 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Glyco_tran_WecB PF03808.13 CCF37965.1 - 0.12 12.3 0.0 0.2 11.6 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferase WecB/TagA/CpsF family DJ-1_PfpI PF01965.24 CCF37966.1 - 3.3e-15 56.3 0.0 1.3e-14 54.4 0.0 1.9 1 1 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.5 CCF37966.1 - 8.8e-13 48.4 0.0 2.3e-12 47.0 0.0 1.6 1 1 0 1 1 1 1 ThiJ/PfpI family-like GATase_3 PF07685.14 CCF37966.1 - 0.097 12.3 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain PSD4 PF07631.11 CCF37966.1 - 0.18 12.3 0.0 0.32 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1592) Rrn6 PF10214.9 CCF37968.1 - 0.5 8.8 6.5 0.67 8.4 6.5 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Amino_oxidase PF01593.24 CCF37969.1 - 6.7e-44 150.9 0.1 7.2e-43 147.5 0.1 2.2 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CCF37969.1 - 7.8e-15 54.9 0.1 2.5e-14 53.3 0.0 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CCF37969.1 - 5e-08 32.5 0.1 3.3e-05 23.3 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CCF37969.1 - 1.2e-05 25.4 0.2 0.068 13.2 0.0 2.4 2 0 0 2 2 2 2 FAD-NAD(P)-binding DAO PF01266.24 CCF37969.1 - 4.5e-05 23.2 0.7 0.00084 19.0 0.1 2.4 3 0 0 3 3 3 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 CCF37969.1 - 5.8e-05 23.6 0.1 0.00014 22.3 0.1 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CCF37969.1 - 0.00012 21.3 0.3 0.0002 20.6 0.3 1.3 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 CCF37969.1 - 0.00016 20.5 0.2 0.0039 16.0 0.1 2.1 2 0 0 2 2 2 1 HI0933-like protein FAD_binding_3 PF01494.19 CCF37969.1 - 0.0014 18.0 0.9 0.0021 17.4 0.9 1.2 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 CCF37969.1 - 0.0089 15.3 0.0 0.015 14.6 0.0 1.2 1 0 0 1 1 1 1 Thi4 family FAD_oxidored PF12831.7 CCF37969.1 - 0.014 14.8 0.0 0.028 13.8 0.0 1.5 2 0 0 2 2 2 0 FAD dependent oxidoreductase 3HCDH_N PF02737.18 CCF37969.1 - 0.049 13.5 0.2 0.09 12.7 0.2 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Lycopene_cycl PF05834.12 CCF37969.1 - 0.054 12.5 0.4 0.087 11.9 0.4 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein AlaDh_PNT_C PF01262.21 CCF37969.1 - 0.2 10.9 0.0 0.32 10.3 0.0 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_3 PF13738.6 CCF37969.1 - 0.25 10.6 2.3 0.43 9.8 0.9 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HpcH_HpaI PF03328.14 CCF37970.1 - 3.3e-31 108.1 0.0 4.2e-31 107.8 0.0 1.1 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family PEP-utilizers_C PF02896.18 CCF37970.1 - 2.6e-05 23.5 0.2 0.00041 19.5 0.2 2.6 2 1 0 2 2 2 1 PEP-utilising enzyme, TIM barrel domain 2-Hacid_dh_C PF02826.19 CCF37971.1 - 2.1e-48 164.0 0.0 3e-48 163.5 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CCF37971.1 - 1.7e-22 79.6 0.0 1.9e-22 79.4 0.0 1.0 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain AdoHcyase_NAD PF00670.21 CCF37971.1 - 4.7e-05 23.5 0.0 8.1e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain NAD_binding_2 PF03446.15 CCF37971.1 - 0.017 15.3 0.0 0.03 14.5 0.0 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.12 CCF37971.1 - 0.031 13.8 0.0 0.051 13.2 0.0 1.4 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain MFS_1 PF07690.16 CCF37973.1 - 8.6e-36 123.6 50.2 8.6e-36 123.6 50.2 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF37973.1 - 5.5e-11 42.0 11.9 5.5e-11 42.0 11.9 2.1 2 0 0 2 2 2 1 Sugar (and other) transporter OATP PF03137.20 CCF37973.1 - 0.15 10.3 12.4 0.023 13.0 3.2 2.3 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family HNH_2 PF13391.6 CCF37974.1 - 1.7e-09 37.7 0.0 3e-09 36.9 0.0 1.4 1 0 0 1 1 1 1 HNH endonuclease Zn_clus PF00172.18 CCF37975.1 - 2.5e-07 30.7 9.9 3.9e-07 30.1 9.9 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 CCF37975.1 - 0.018 13.9 0.0 0.027 13.3 0.0 1.3 1 0 0 1 1 1 0 Fungal specific transcription factor domain Fumarate_red_C PF02300.17 CCF37975.1 - 0.061 13.4 0.3 0.12 12.5 0.3 1.4 1 0 0 1 1 1 0 Fumarate reductase subunit C Fungal_trans PF04082.18 CCF37976.1 - 2.6e-68 230.0 0.0 3.6e-68 229.5 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Hep_59 PF07052.11 CCF37978.1 - 1e-16 61.6 0.3 1.1e-15 58.3 0.0 2.9 2 1 0 2 2 2 1 Hepatocellular carcinoma-associated antigen 59 LIN37 PF15306.6 CCF37978.1 - 7.6 6.7 8.5 0.97 9.6 0.2 2.8 3 0 0 3 3 3 0 LIN37 Acylphosphatase PF00708.18 CCF37979.1 - 1.4e-23 83.1 0.1 1.5e-23 83.0 0.1 1.0 1 0 0 1 1 1 1 Acylphosphatase Ank_2 PF12796.7 CCF37980.1 - 3e-45 152.7 0.9 2.6e-14 53.5 0.0 9.4 6 2 4 10 10 10 7 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CCF37980.1 - 2.1e-30 101.4 8.5 0.0056 17.1 0.0 13.7 15 0 0 15 15 15 6 Ankyrin repeat Ank_4 PF13637.6 CCF37980.1 - 3.5e-29 100.8 2.9 7e-08 32.9 0.0 9.9 10 1 1 11 11 11 6 Ankyrin repeats (many copies) Ank PF00023.30 CCF37980.1 - 2.5e-25 87.7 9.4 0.0031 17.9 0.0 11.8 12 0 0 12 12 12 6 Ankyrin repeat Ank_5 PF13857.6 CCF37980.1 - 1.9e-24 85.4 8.1 0.00047 20.4 0.0 10.7 10 2 1 11 11 11 6 Ankyrin repeats (many copies) adh_short_C2 PF13561.6 CCF37981.1 - 9.1e-57 192.3 7.7 1.1e-56 192.0 7.7 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF37981.1 - 9.5e-49 165.5 5.0 1.2e-48 165.2 5.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF37981.1 - 7.3e-14 52.1 3.9 1.1e-13 51.5 3.9 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF37981.1 - 0.0035 16.8 2.8 0.0088 15.5 2.7 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family PNGaseA PF12222.8 CCF37981.1 - 0.011 14.6 0.0 0.016 14.1 0.0 1.2 1 0 0 1 1 1 0 Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A Ketoacyl-synt_C PF02801.22 CCF37981.1 - 0.014 15.4 0.2 0.034 14.2 0.2 1.6 1 0 0 1 1 1 0 Beta-ketoacyl synthase, C-terminal domain 3HCDH_N PF02737.18 CCF37981.1 - 0.033 14.1 1.0 0.054 13.4 1.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain THF_DHG_CYH_C PF02882.19 CCF37981.1 - 0.066 12.5 2.3 0.069 12.5 0.9 1.8 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain COesterase PF00135.28 CCF37982.1 - 1.5e-87 294.6 0.3 9.3e-79 265.6 0.1 2.0 1 1 0 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.13 CCF37982.1 - 2.3e-15 57.0 0.1 3.7e-15 56.3 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Cupin_1 PF00190.22 CCF37984.1 - 1.8e-15 56.8 0.2 2.8e-15 56.2 0.0 1.4 2 0 0 2 2 2 1 Cupin Cupin_2 PF07883.11 CCF37984.1 - 0.02 14.6 0.1 0.04 13.6 0.1 1.6 1 1 0 1 1 1 0 Cupin domain MFS_1 PF07690.16 CCF37985.1 - 1.6e-36 126.0 28.5 1.6e-36 126.0 28.5 1.5 1 1 1 2 2 2 1 Major Facilitator Superfamily HpcH_HpaI PF03328.14 CCF37986.1 - 1.2e-21 76.9 0.0 2e-21 76.1 0.0 1.3 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family WD40 PF00400.32 CCF37987.1 - 3e-12 46.9 5.6 0.00054 20.7 0.0 5.2 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF37987.1 - 0.00034 20.8 0.5 1.5 9.2 0.0 3.9 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Peptidase_S28 PF05577.12 CCF37988.1 - 6.4e-45 153.7 0.2 1.7e-44 152.3 0.2 1.6 1 1 0 1 1 1 1 Serine carboxypeptidase S28 DUF2920 PF11144.8 CCF37988.1 - 0.13 11.4 0.1 0.2 10.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2920) Sugar_tr PF00083.24 CCF37990.1 - 6.2e-15 55.0 11.1 6.8e-15 54.9 11.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF37990.1 - 0.00015 20.9 5.6 0.00016 20.7 5.6 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily 7tm_1 PF00001.21 CCF37990.1 - 0.02 14.3 0.3 0.033 13.5 0.3 1.4 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Sugar_tr PF00083.24 CCF37991.1 - 9.6e-105 351.0 20.4 1.2e-104 350.7 20.4 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF37991.1 - 3.3e-24 85.5 32.7 6.5e-21 74.6 26.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 CCF37991.1 - 1.2e-06 27.2 10.2 3.3e-06 25.8 4.5 2.1 2 0 0 2 2 2 2 Fungal trichothecene efflux pump (TRI12) Skp1 PF01466.19 CCF37991.1 - 0.54 10.4 1.9 0.78 9.9 1.1 1.6 2 0 0 2 2 2 0 Skp1 family, dimerisation domain DUF3566 PF12089.8 CCF37991.1 - 1.2 9.5 5.1 24 5.3 0.1 3.7 4 0 0 4 4 4 0 Transmembrane domain of unknown function (DUF3566) Pirin PF02678.16 CCF37993.1 - 3.6e-30 104.1 0.0 9.3e-30 102.8 0.0 1.7 1 0 0 1 1 1 1 Pirin Pirin_C PF05726.13 CCF37993.1 - 6.4e-26 90.7 0.0 1.2e-24 86.6 0.0 2.3 2 0 0 2 2 2 1 Pirin C-terminal cupin domain Cupin_2 PF07883.11 CCF37993.1 - 2.6e-06 27.1 2.9 0.00039 20.1 0.7 2.5 2 0 0 2 2 2 2 Cupin domain Cupin_3 PF05899.12 CCF37993.1 - 0.011 15.4 0.5 0.65 9.7 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF861) Androgen_recep PF02166.16 CCF37993.1 - 0.14 11.0 0.7 0.19 10.5 0.7 1.2 1 0 0 1 1 1 0 Androgen receptor Sec6 PF06046.13 CCF37994.1 - 4.5e-167 556.9 8.8 7.2e-167 556.2 8.8 1.3 1 0 0 1 1 1 1 Exocyst complex component Sec6 Vps53_N PF04100.12 CCF37994.1 - 0.0074 15.3 1.5 0.0074 15.3 1.5 2.2 2 1 1 3 3 3 1 Vps53-like, N-terminal OmdA PF13376.6 CCF37994.1 - 0.098 12.7 3.1 0.29 11.2 0.0 3.0 3 0 0 3 3 3 0 Bacteriocin-protection, YdeI or OmpD-Associated DUF755 PF05501.11 CCF37994.1 - 0.22 11.8 0.5 0.43 10.9 0.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF755) CAP59_mtransfer PF11735.8 CCF37995.1 - 3.4e-63 213.5 0.0 4.2e-63 213.3 0.0 1.1 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 ABC_tran PF00005.27 CCF37996.1 - 1.7e-43 148.4 6.0 1.1e-21 77.8 0.0 3.7 3 1 0 3 3 2 2 ABC transporter AAA_21 PF13304.6 CCF37996.1 - 6.9e-12 45.8 7.9 0.00024 21.0 0.0 4.5 4 0 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CCF37996.1 - 9.6e-10 38.1 0.4 0.00017 21.3 0.0 3.5 3 0 0 3 3 3 2 P-loop containing region of AAA domain SMC_N PF02463.19 CCF37996.1 - 3.7e-09 36.3 2.3 0.041 13.3 0.0 4.4 4 1 0 5 5 5 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 CCF37996.1 - 1.4e-06 28.4 1.1 0.09 12.9 0.1 3.5 4 0 0 4 4 3 2 50S ribosome-binding GTPase ABC_tran_Xtn PF12848.7 CCF37996.1 - 2.9e-06 27.2 2.9 1e-05 25.5 2.9 1.9 1 0 0 1 1 1 1 ABC transporter RsgA_GTPase PF03193.16 CCF37996.1 - 6.2e-06 26.2 2.5 0.057 13.3 0.0 3.0 3 0 0 3 3 3 2 RsgA GTPase AAA_30 PF13604.6 CCF37996.1 - 6.7e-06 25.9 0.3 0.035 13.8 0.0 3.0 3 0 0 3 3 3 2 AAA domain AAA_18 PF13238.6 CCF37996.1 - 2e-05 25.1 0.1 0.42 11.2 0.1 3.1 2 0 0 2 2 2 2 AAA domain AAA_28 PF13521.6 CCF37996.1 - 2.3e-05 24.7 0.4 0.027 14.7 0.0 2.7 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 CCF37996.1 - 2.6e-05 24.2 0.1 0.017 15.0 0.0 2.6 2 0 0 2 2 2 1 NACHT domain AAA_22 PF13401.6 CCF37996.1 - 2.6e-05 24.5 0.8 0.3 11.3 0.0 3.3 3 1 0 3 3 3 2 AAA domain MeaB PF03308.16 CCF37996.1 - 9.6e-05 21.5 0.7 0.059 12.3 0.1 2.5 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_16 PF13191.6 CCF37996.1 - 0.00021 21.7 4.3 0.27 11.6 0.1 3.0 2 2 0 2 2 2 2 AAA ATPase domain DUF87 PF01935.17 CCF37996.1 - 0.00027 21.1 11.2 0.017 15.2 0.3 3.3 4 0 0 4 4 4 2 Helicase HerA, central domain AAA_33 PF13671.6 CCF37996.1 - 0.00046 20.4 4.2 0.39 10.9 0.1 3.5 2 1 0 2 2 2 2 AAA domain AAA_27 PF13514.6 CCF37996.1 - 0.00088 18.9 0.0 0.046 13.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain Thymidylate_kin PF02223.17 CCF37996.1 - 0.0013 18.4 0.1 0.34 10.6 0.0 2.7 2 0 0 2 2 2 1 Thymidylate kinase AAA PF00004.29 CCF37996.1 - 0.0014 19.1 0.1 0.74 10.3 0.0 2.8 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.13 CCF37996.1 - 0.0037 16.5 0.1 2.2 7.4 0.0 2.7 2 0 0 2 2 2 1 Protein of unknown function (DUF815) NTPase_1 PF03266.15 CCF37996.1 - 0.0038 17.2 0.2 2.7 7.9 0.0 2.9 3 0 0 3 3 3 1 NTPase AAA_14 PF13173.6 CCF37996.1 - 0.0039 17.2 0.1 4.2 7.4 0.0 3.4 4 0 0 4 4 3 0 AAA domain Dynamin_N PF00350.23 CCF37996.1 - 0.0049 16.9 3.4 1.4 9.0 0.0 3.1 3 0 0 3 3 2 2 Dynamin family RNA_helicase PF00910.22 CCF37996.1 - 0.0062 16.9 0.1 1.5 9.3 0.0 2.5 2 0 0 2 2 2 1 RNA helicase Arf PF00025.21 CCF37996.1 - 0.0071 15.8 0.6 0.14 11.6 0.1 2.3 2 0 0 2 2 2 1 ADP-ribosylation factor family AAA_24 PF13479.6 CCF37996.1 - 0.0098 15.6 1.0 1.9 8.2 0.0 2.8 3 0 0 3 3 2 1 AAA domain TsaE PF02367.17 CCF37996.1 - 0.013 15.5 0.6 2.8 8.0 0.0 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase_2 PF01637.18 CCF37996.1 - 0.015 15.3 0.0 0.8 9.6 0.0 2.4 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea ATP-synt_ab PF00006.25 CCF37996.1 - 0.017 14.8 0.0 2.8 7.5 0.0 2.4 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_15 PF13175.6 CCF37996.1 - 0.021 14.5 0.2 0.021 14.5 0.2 3.7 3 1 0 4 4 4 0 AAA ATPase domain MukB PF04310.12 CCF37996.1 - 0.029 14.2 0.1 0.24 11.2 0.0 2.2 2 0 0 2 2 2 0 MukB N-terminal Roc PF08477.13 CCF37996.1 - 0.033 14.4 0.6 12 6.2 0.0 2.8 3 0 0 3 3 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_17 PF13207.6 CCF37996.1 - 0.036 14.5 7.9 4.3 7.8 0.0 4.0 4 0 0 4 4 3 0 AAA domain AAA_23 PF13476.6 CCF37996.1 - 0.048 14.2 21.1 2.8 8.4 0.2 4.0 3 1 0 3 3 3 0 AAA domain ATP_bind_1 PF03029.17 CCF37996.1 - 0.049 13.4 0.1 21 4.8 0.1 3.1 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein AAA_5 PF07728.14 CCF37996.1 - 0.052 13.5 0.3 2 8.4 0.0 3.1 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.12 CCF37996.1 - 0.059 12.7 0.8 7.5 5.8 0.1 2.5 2 0 0 2 2 2 0 Zeta toxin AAA_7 PF12775.7 CCF37996.1 - 0.06 12.9 0.1 2.7 7.4 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region G-alpha PF00503.20 CCF37996.1 - 0.073 12.2 0.2 0.81 8.8 0.0 2.3 2 0 0 2 2 2 0 G-protein alpha subunit MobB PF03205.14 CCF37996.1 - 0.079 12.9 0.3 17 5.3 0.2 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Viral_helicase1 PF01443.18 CCF37996.1 - 0.11 12.3 0.1 20 4.8 0.0 2.9 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase Ploopntkinase1 PF18748.1 CCF37996.1 - 0.14 11.6 0.0 21 4.5 0.0 2.6 3 0 0 3 3 2 0 P-loop Nucleotide Kinase1 NB-ARC PF00931.22 CCF37996.1 - 0.16 11.2 7.2 1.8 7.7 0.0 3.7 4 0 0 4 4 4 0 NB-ARC domain cobW PF02492.19 CCF37996.1 - 0.2 11.2 1.5 18 4.9 0.0 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain dNK PF01712.19 CCF37996.1 - 0.2 11.5 0.3 9.8 6.0 0.1 2.3 2 0 0 2 2 2 0 Deoxynucleoside kinase PduV-EutP PF10662.9 CCF37996.1 - 0.24 11.1 0.5 3.1 7.5 0.0 2.5 3 0 0 3 3 2 0 Ethanolamine utilisation - propanediol utilisation SET PF00856.28 CCF37997.1 - 2.1e-13 51.0 0.0 5.9e-13 49.6 0.0 1.7 1 1 0 1 1 1 1 SET domain SAF PF08666.12 CCF37997.1 - 0.012 16.2 0.1 6.8 7.4 0.0 2.6 2 0 0 2 2 2 0 SAF domain Pkinase PF00069.25 CCF37999.1 - 4.8e-62 209.7 0.0 5.4e-62 209.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF37999.1 - 6.6e-41 140.3 0.0 8.8e-41 139.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF37999.1 - 1.7e-08 34.1 0.0 3.9e-08 32.9 0.0 1.6 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 CCF37999.1 - 1.8e-07 30.3 0.0 2.5e-07 29.8 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 CCF37999.1 - 0.0019 17.2 0.1 0.0027 16.7 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 CCF37999.1 - 0.0079 16.1 0.0 0.047 13.6 0.0 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 CCF37999.1 - 0.014 14.7 0.0 0.026 13.9 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 CCF37999.1 - 0.061 12.9 0.0 0.089 12.4 0.0 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 DSHCT PF08148.12 CCF37999.1 - 0.066 12.9 0.1 0.14 11.8 0.0 1.6 2 0 0 2 2 2 0 DSHCT (NUC185) domain Seadorna_VP7 PF07387.11 CCF37999.1 - 0.072 12.1 0.0 0.099 11.7 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Ysc84 PF04366.12 CCF38000.1 - 3.9e-41 139.8 0.5 7.6e-41 138.9 0.5 1.5 1 0 0 1 1 1 1 Las17-binding protein actin regulator SH3_1 PF00018.28 CCF38000.1 - 9.7e-14 50.7 0.2 2.5e-13 49.4 0.1 1.8 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 CCF38000.1 - 5.5e-12 45.2 0.0 1.7e-11 43.6 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 CCF38000.1 - 1.4e-10 40.9 0.0 3e-10 39.8 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain DUF3104 PF11302.8 CCF38000.1 - 0.051 13.3 0.1 0.11 12.2 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3104) Glyco_hydro_18 PF00704.28 CCF38001.1 - 4.1e-74 250.1 0.2 4.9e-74 249.9 0.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Chitin_bind_1 PF00187.19 CCF38001.1 - 9.3e-09 35.6 21.7 9.3e-09 35.6 21.7 2.3 2 0 0 2 2 2 1 Chitin recognition protein HTH_psq PF05225.16 CCF38002.1 - 5.5e-11 42.0 0.0 8.7e-11 41.4 0.0 1.3 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_23 PF13384.6 CCF38002.1 - 0.0067 16.2 0.1 0.022 14.5 0.0 1.7 2 0 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.6 CCF38002.1 - 0.075 13.2 0.0 0.17 12.1 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain DDHD PF02862.17 CCF38003.1 - 7.5e-05 23.0 0.0 0.00014 22.1 0.0 1.5 1 0 0 1 1 1 1 DDHD domain Hydrolase_4 PF12146.8 CCF38003.1 - 0.02 14.2 0.0 0.41 9.9 0.0 2.3 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CCF38003.1 - 0.022 14.4 0.0 0.052 13.2 0.0 1.6 1 1 0 1 1 1 0 alpha/beta hydrolase fold COG5 PF10392.9 CCF38009.1 - 0.031 14.5 1.3 0.078 13.2 1.3 1.6 1 0 0 1 1 1 0 Golgi transport complex subunit 5 DUF3490 PF11995.8 CCF38009.1 - 0.17 11.7 1.1 0.74 9.6 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3490) Vps54_N PF10475.9 CCF38009.1 - 0.2 10.9 0.5 0.34 10.1 0.5 1.3 1 0 0 1 1 1 0 Vacuolar-sorting protein 54, of GARP complex DHHC PF01529.20 CCF38011.1 - 1.1 9.3 7.2 2.4 8.3 3.6 2.6 2 1 1 3 3 3 0 DHHC palmitoyltransferase DUF2070 PF09843.9 CCF38011.1 - 3.7 5.7 7.1 5 5.3 7.1 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Methyltransf_2 PF00891.18 CCF38012.1 - 6.9e-21 74.5 0.0 1.1e-20 73.8 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain Dimerisation2 PF16864.5 CCF38012.1 - 0.046 13.7 0.0 0.1 12.6 0.0 1.5 1 0 0 1 1 1 0 Dimerisation domain THF_DHG_CYH PF00763.23 CCF38013.1 - 2.6e-26 92.2 0.0 3.9e-26 91.6 0.0 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain THF_DHG_CYH_C PF02882.19 CCF38013.1 - 1.7e-14 53.4 0.0 9.6e-09 34.8 0.0 2.6 2 1 0 2 2 2 2 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Apq12 PF12716.7 CCF38015.1 - 1.1e-15 57.2 16.6 2.2e-15 56.3 16.6 1.5 1 0 0 1 1 1 1 Nuclear pore assembly and biogenesis YqjK PF13997.6 CCF38015.1 - 1.8 8.8 7.8 0.5 10.6 0.9 2.3 2 0 0 2 2 2 0 YqjK-like protein ATP_bind_1 PF03029.17 CCF38016.1 - 5e-72 242.6 0.0 6.4e-72 242.2 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_24 PF13479.6 CCF38016.1 - 0.00045 20.0 0.0 0.0008 19.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain CLP1_P PF16575.5 CCF38016.1 - 0.00053 19.8 0.0 0.0012 18.7 0.0 1.5 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_14 PF13173.6 CCF38016.1 - 0.00069 19.6 0.0 0.0019 18.3 0.0 1.9 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 CCF38016.1 - 0.0035 17.7 0.0 0.0088 16.4 0.0 1.7 1 0 0 1 1 1 1 RNA helicase AAA_18 PF13238.6 CCF38016.1 - 0.0041 17.7 0.0 0.0099 16.4 0.0 1.7 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 CCF38016.1 - 0.011 15.7 0.1 0.45 10.4 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase CbiA PF01656.23 CCF38016.1 - 0.011 15.8 0.0 0.012 15.6 0.0 1.3 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain GTP_EFTU PF00009.27 CCF38016.1 - 0.013 15.1 0.0 3.6 7.1 0.0 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 CCF38016.1 - 0.015 15.5 0.0 0.03 14.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 CCF38016.1 - 0.018 15.2 0.0 0.027 14.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 CCF38016.1 - 0.054 13.0 0.0 0.087 12.3 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region KAP_NTPase PF07693.14 CCF38016.1 - 0.078 12.2 0.0 0.078 12.2 0.0 1.3 1 1 0 1 1 1 0 KAP family P-loop domain SRP54 PF00448.22 CCF38016.1 - 0.079 12.6 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain ABC_tran PF00005.27 CCF38016.1 - 0.079 13.5 0.0 0.16 12.5 0.0 1.4 1 0 0 1 1 1 0 ABC transporter PPV_E1_C PF00519.17 CCF38016.1 - 0.091 11.6 0.0 0.14 11.0 0.0 1.2 1 0 0 1 1 1 0 Papillomavirus helicase AAA_16 PF13191.6 CCF38016.1 - 0.099 13.0 0.0 0.24 11.8 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain cobW PF02492.19 CCF38016.1 - 0.1 12.2 0.1 7 6.2 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_29 PF13555.6 CCF38016.1 - 0.1 12.3 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Septin PF00735.18 CCF38016.1 - 0.11 11.8 0.0 0.17 11.1 0.0 1.3 1 0 0 1 1 1 0 Septin Cytidylate_kin PF02224.18 CCF38016.1 - 0.11 12.2 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 Cytidylate kinase PduV-EutP PF10662.9 CCF38016.1 - 0.12 12.2 0.0 1.7 8.4 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation NACHT PF05729.12 CCF38016.1 - 0.13 12.2 0.0 0.21 11.5 0.0 1.3 1 0 0 1 1 1 0 NACHT domain AAA_25 PF13481.6 CCF38016.1 - 0.14 11.8 0.0 1.1 8.8 0.0 2.1 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 CCF38016.1 - 0.14 12.2 0.0 0.4 10.8 0.0 2.0 1 1 0 1 1 1 0 50S ribosome-binding GTPase Ribosomal_L5_C PF00673.21 CCF38017.1 - 1.2e-22 79.9 0.0 1.8e-22 79.3 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 CCF38017.1 - 1.1e-19 70.5 0.0 3.2e-19 69.0 0.0 1.8 2 0 0 2 2 2 1 Ribosomal protein L5 ATP-synt_ab PF00006.25 CCF38018.1 - 2e-72 243.3 0.0 3e-72 242.7 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.27 CCF38018.1 - 9.5e-47 158.4 0.1 1.7e-46 157.7 0.1 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.23 CCF38018.1 - 3.9e-15 56.1 3.0 1.1e-14 54.7 3.0 1.8 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain Sugar_tr PF00083.24 CCF38019.1 - 6e-67 226.4 28.2 6.9e-67 226.2 28.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF38019.1 - 4e-18 65.5 41.4 2.9e-15 56.0 30.2 2.9 2 1 1 3 3 3 2 Major Facilitator Superfamily MFS_1_like PF12832.7 CCF38019.1 - 0.00068 18.6 0.7 0.00068 18.6 0.7 2.5 1 1 1 2 2 2 1 MFS_1 like family adh_short PF00106.25 CCF38020.1 - 3.1e-35 121.4 0.0 4.6e-35 120.8 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF38020.1 - 5.7e-25 88.2 0.0 8e-25 87.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF38020.1 - 8.3e-08 32.4 0.7 8.2e-05 22.6 0.0 2.3 2 0 0 2 2 2 2 KR domain Epimerase PF01370.21 CCF38020.1 - 0.0054 16.2 0.0 0.0095 15.4 0.0 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 CCF38020.1 - 0.0055 15.8 0.0 0.0089 15.2 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain HRDC PF00570.23 CCF38020.1 - 0.45 10.5 1.7 2.5 8.1 0.4 2.3 2 0 0 2 2 2 0 HRDC domain Hydrolase_4 PF12146.8 CCF38021.1 - 3.6e-08 33.0 0.1 3.6e-08 33.0 0.1 1.0 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 CCF38021.1 - 1e-07 31.7 0.0 1.2e-07 31.5 0.0 1.0 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 CCF38021.1 - 1.5e-07 31.3 0.4 1.5e-07 31.3 0.4 1.0 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_6 PF12697.7 CCF38021.1 - 2.3e-05 25.1 0.8 2.5e-05 25.0 0.8 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CCF38021.1 - 0.013 15.1 0.0 0.015 14.9 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF5534 PF17686.1 CCF38022.1 - 2.2 8.5 6.0 0.59 10.4 0.9 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5534) p450 PF00067.22 CCF38023.1 - 3.4e-51 174.4 0.0 4.7e-51 174.0 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 ketoacyl-synt PF00109.26 CCF38024.1 - 7.9e-50 169.8 0.0 8.9e-50 169.6 0.0 1.0 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Thiolase_N PF00108.23 CCF38024.1 - 4.8e-05 22.8 0.1 7.5e-05 22.2 0.1 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain ACP_syn_III PF08545.10 CCF38024.1 - 0.001 18.9 0.4 0.0026 17.6 0.4 1.7 1 1 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III UPF0139 PF03669.13 CCF38026.1 - 4.6e-07 29.6 0.0 6.2e-07 29.2 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0139) Tir_receptor_C PF07489.11 CCF38028.1 - 0.044 13.8 1.9 0.056 13.4 1.9 1.1 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus Pro-kuma_activ PF09286.11 CCF38029.1 - 2.4e-36 125.1 0.1 6.8e-36 123.7 0.0 1.7 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 CCF38029.1 - 6.8e-05 22.3 0.3 0.00011 21.6 0.3 1.2 1 0 0 1 1 1 1 Subtilase family BcsB PF03170.13 CCF38031.1 - 0.031 12.7 0.0 0.36 9.2 0.0 1.9 1 1 1 2 2 2 0 Bacterial cellulose synthase subunit S_layer_C PF05124.12 CCF38031.1 - 0.045 13.8 0.0 0.05 13.6 0.0 1.2 1 0 0 1 1 1 0 S-layer like family, C-terminal region Glyco_hydro_67N PF03648.14 CCF38031.1 - 0.082 13.2 0.1 0.43 10.9 0.1 2.0 1 1 0 1 1 1 0 Glycosyl hydrolase family 67 N-terminus EamA PF00892.20 CCF38035.1 - 1.9e-05 24.8 4.3 2.4e-05 24.5 4.3 1.1 1 0 0 1 1 1 1 EamA-like transporter family TPT PF03151.16 CCF38035.1 - 0.00018 20.9 1.3 0.00021 20.7 1.3 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family PHO4 PF01384.20 CCF38035.1 - 0.041 12.9 5.1 0.048 12.7 4.8 1.2 1 1 0 1 1 1 0 Phosphate transporter family Peptidase_A24 PF01478.18 CCF38035.1 - 0.7 10.3 4.3 5.4 7.5 3.4 2.2 1 1 0 1 1 1 0 Type IV leader peptidase family PNP_UDP_1 PF01048.20 CCF38036.1 - 4.1e-13 49.1 0.8 6.8e-12 45.1 0.8 2.2 1 1 0 1 1 1 1 Phosphorylase superfamily NACHT_sigma PF17106.5 CCF38036.1 - 6.8e-10 38.9 14.5 1.4e-09 38.0 12.8 2.2 2 0 0 2 2 2 1 Sigma domain on NACHT-NTPases WD40 PF00400.32 CCF38037.1 - 2.4e-35 119.9 29.3 3.1e-07 31.0 0.1 9.0 9 0 0 9 9 9 6 WD domain, G-beta repeat NACHT PF05729.12 CCF38037.1 - 1.5e-17 64.0 0.0 2.8e-17 63.1 0.0 1.4 1 0 0 1 1 1 1 NACHT domain ANAPC4_WD40 PF12894.7 CCF38037.1 - 2.1e-16 60.0 5.1 0.019 15.3 0.1 8.5 4 2 4 9 9 9 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CCF38037.1 - 1.2e-07 31.0 12.1 0.22 10.5 0.5 6.3 3 2 5 8 8 8 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 CCF38037.1 - 4.7e-06 26.6 3.2 0.17 11.7 0.0 3.4 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A RAB3GAP2_N PF14655.6 CCF38037.1 - 0.00094 18.5 0.1 0.0019 17.5 0.1 1.4 1 0 0 1 1 1 1 Rab3 GTPase-activating protein regulatory subunit N-terminus NACHT_sigma PF17106.5 CCF38037.1 - 0.0015 18.6 8.9 0.0015 18.6 8.9 1.9 2 0 0 2 2 2 1 Sigma domain on NACHT-NTPases AAA_16 PF13191.6 CCF38037.1 - 0.0016 18.8 0.0 0.0039 17.6 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain DUF1513 PF07433.11 CCF38037.1 - 0.0037 16.4 4.5 34 3.4 0.0 5.1 3 1 1 5 5 5 0 Protein of unknown function (DUF1513) Nup160 PF11715.8 CCF38037.1 - 0.0064 15.2 11.9 0.31 9.6 0.2 4.6 4 1 1 5 5 5 2 Nucleoporin Nup120/160 DUF1353 PF07087.11 CCF38037.1 - 0.063 13.0 0.0 0.15 11.8 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1353) PD40 PF07676.12 CCF38037.1 - 0.16 12.0 0.2 1.2 9.1 0.1 2.7 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat zf-C2H2 PF00096.26 CCF38038.1 - 0.00037 20.8 0.8 0.00037 20.8 0.8 4.5 5 0 0 5 5 5 1 Zinc finger, C2H2 type zf-C2H2_8 PF15909.5 CCF38038.1 - 0.071 13.4 2.9 0.076 13.3 0.3 2.4 3 0 0 3 3 3 0 C2H2-type zinc ribbon IBR PF01485.21 CCF38038.1 - 0.22 11.8 2.6 8.9 6.6 0.0 2.5 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain zf-C2H2_jaz PF12171.8 CCF38038.1 - 0.5 10.7 0.1 0.5 10.7 0.1 2.1 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Sina PF03145.16 CCF38038.1 - 6.4 6.7 12.7 3.9 7.4 2.3 2.2 1 1 1 2 2 2 0 Seven in absentia protein family MutS_I PF01624.20 CCF38039.1 - 1.7e-16 60.5 0.2 2.3e-16 60.0 0.2 1.2 1 0 0 1 1 1 1 MutS domain I Pex14_N PF04695.13 CCF38041.1 - 0.00023 21.8 2.8 0.00023 21.8 2.8 1.7 2 0 0 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Presenilin PF01080.17 CCF38041.1 - 0.038 12.8 0.0 0.038 12.8 0.0 1.4 2 0 0 2 2 2 0 Presenilin TFIIA PF03153.13 CCF38041.1 - 0.29 11.1 9.4 0.39 10.7 9.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit p450 PF00067.22 CCF38042.1 - 6e-23 81.3 0.0 6.5e-23 81.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Esterase_phd PF10503.9 CCF38043.1 - 8.7e-23 81.0 1.0 1.4e-22 80.3 1.0 1.3 1 0 0 1 1 1 1 Esterase PHB depolymerase CBM_1 PF00734.18 CCF38043.1 - 5e-13 48.7 3.8 5e-13 48.7 3.8 2.4 2 0 0 2 2 2 1 Fungal cellulose binding domain Peptidase_S9 PF00326.21 CCF38043.1 - 5.5e-10 39.1 1.9 8.6e-10 38.4 1.9 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Esterase PF00756.20 CCF38043.1 - 0.019 14.6 0.4 0.028 14.1 0.4 1.4 1 0 0 1 1 1 0 Putative esterase DUF4142 PF13628.6 CCF38045.1 - 0.097 12.9 0.5 0.16 12.2 0.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4142) CMAS PF02353.20 CCF38046.1 - 1.5e-24 86.7 0.1 1.8e-24 86.5 0.1 1.0 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.6 CCF38046.1 - 0.048 13.5 0.0 0.07 13.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain RRM_1 PF00076.22 CCF38047.1 - 0.01 15.6 0.0 0.011 15.5 0.0 1.1 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) STAS PF01740.21 CCF38048.1 - 1.9e-10 40.4 0.0 2.8e-10 39.8 0.0 1.2 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.6 CCF38048.1 - 0.0022 18.3 1.1 0.0022 18.3 1.1 2.5 2 1 0 2 2 2 1 STAS domain Sulfate_transp PF00916.20 CCF38048.1 - 0.032 13.0 0.1 0.044 12.5 0.1 1.2 1 0 0 1 1 1 0 Sulfate permease family DNA_pol_B_thumb PF14791.6 CCF38050.1 - 9.5e-21 73.7 0.0 2.3e-20 72.5 0.0 1.7 1 0 0 1 1 1 1 DNA polymerase beta thumb DNA_pol_B_palm PF14792.6 CCF38050.1 - 1.1e-14 54.6 0.0 2e-14 53.7 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase beta palm HHH_8 PF14716.6 CCF38050.1 - 2.3e-08 34.3 0.0 4.4e-08 33.4 0.0 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix domain DNA_pol_lambd_f PF10391.9 CCF38050.1 - 0.00056 19.7 0.1 0.0027 17.5 0.0 2.2 3 0 0 3 3 3 1 Fingers domain of DNA polymerase lambda NTP_transf_2 PF01909.23 CCF38050.1 - 0.021 15.1 0.0 0.045 14.0 0.0 1.5 1 0 0 1 1 1 0 Nucleotidyltransferase domain BRCT_2 PF16589.5 CCF38050.1 - 0.16 12.4 0.0 0.36 11.3 0.0 1.6 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain TFIIE_alpha PF02002.17 CCF38051.1 - 1.6e-14 53.7 0.2 3.7e-14 52.5 0.2 1.6 1 0 0 1 1 1 1 TFIIE alpha subunit zf-CCHC_2 PF13696.6 CCF38051.1 - 0.011 15.5 0.2 0.011 15.5 0.2 2.0 2 0 0 2 2 2 0 Zinc knuckle DUF4407 PF14362.6 CCF38051.1 - 0.016 14.6 2.4 0.024 14.0 2.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) zf-Dof PF02701.15 CCF38051.1 - 0.069 13.3 0.4 0.15 12.3 0.4 1.5 1 0 0 1 1 1 0 Dof domain, zinc finger zf-FPG_IleRS PF06827.14 CCF38051.1 - 0.092 12.6 1.7 5.1 7.0 0.2 2.4 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS zf_UBZ PF18439.1 CCF38051.1 - 0.23 11.1 1.7 8 6.1 0.0 2.8 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger R3H-assoc PF13902.6 CCF38051.1 - 0.78 10.1 8.5 14 6.1 5.9 3.0 3 1 0 3 3 3 0 R3H-associated N-terminal domain E1-E2_ATPase PF00122.20 CCF38052.1 - 1.8e-48 164.5 3.8 4.6e-48 163.1 3.8 1.7 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 CCF38052.1 - 2.7e-21 76.8 0.1 5e-21 76.0 0.1 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 CCF38052.1 - 9.2e-06 25.6 0.2 0.00053 19.8 0.1 2.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 CCF38052.1 - 0.00034 21.0 5.0 0.00046 20.6 0.1 3.2 3 0 0 3 3 3 1 Heavy-metal-associated domain HAD PF12710.7 CCF38052.1 - 0.095 13.1 0.0 0.22 11.9 0.0 1.6 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Amidohydro_2 PF04909.14 CCF38053.1 - 5.2e-23 82.3 0.1 2e-22 80.3 0.0 1.8 2 0 0 2 2 2 1 Amidohydrolase Spt5-NGN PF03439.13 CCF38053.1 - 0.15 12.0 0.0 0.32 10.9 0.0 1.5 1 0 0 1 1 1 0 Early transcription elongation factor of RNA pol II, NGN section AMPK1_CBM PF16561.5 CCF38054.1 - 0.032 14.4 0.0 0.07 13.4 0.0 1.5 1 1 0 1 1 1 0 Glycogen recognition site of AMP-activated protein kinase Neur_chan_memb PF02932.16 CCF38054.1 - 0.21 11.6 1.5 0.29 11.2 1.5 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Sec3_C PF09763.9 CCF38054.1 - 0.81 8.0 4.8 0.91 7.8 4.8 1.1 1 0 0 1 1 1 0 Exocyst complex component Sec3 Presenilin PF01080.17 CCF38054.1 - 1.4 7.6 5.1 1.7 7.3 5.1 1.1 1 0 0 1 1 1 0 Presenilin NPR3 PF03666.13 CCF38054.1 - 4.2 6.0 9.3 5.6 5.6 9.3 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 FAM76 PF16046.5 CCF38054.1 - 6 6.1 10.2 8.8 5.6 10.2 1.2 1 0 0 1 1 1 0 FAM76 protein HD PF01966.22 CCF38055.1 - 3.8e-07 30.4 0.9 6.8e-07 29.5 0.2 1.8 2 0 0 2 2 2 1 HD domain SRI PF08236.11 CCF38055.1 - 0.014 15.5 0.1 0.066 13.4 0.1 1.9 2 0 0 2 2 2 0 SRI (Set2 Rpb1 interacting) domain F-box-like PF12937.7 CCF38057.1 - 2e-05 24.4 1.0 0.00018 21.4 0.9 2.4 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 CCF38057.1 - 2.2e-05 24.2 1.0 5.9e-05 22.8 1.0 1.7 1 0 0 1 1 1 1 F-box domain Fasciclin PF02469.22 CCF38058.1 - 1.2e-29 103.2 0.2 1.1e-19 70.9 0.0 2.6 2 1 0 2 2 2 2 Fasciclin domain MTHFR PF02219.17 CCF38058.1 - 0.11 11.8 0.0 0.17 11.2 0.0 1.2 1 0 0 1 1 1 0 Methylenetetrahydrofolate reductase MFS_1 PF07690.16 CCF38059.1 - 7.2e-39 133.7 17.7 1.2e-38 133.0 11.6 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF38059.1 - 1.6e-12 47.1 0.7 1.6e-12 47.1 0.7 2.2 2 0 0 2 2 2 1 Sugar (and other) transporter NPR3 PF03666.13 CCF38060.1 - 0.043 12.6 1.3 0.067 12.0 1.3 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 PP28 PF10252.9 CCF38060.1 - 2.3 8.8 11.0 1.6 9.2 0.7 2.3 2 0 0 2 2 2 0 Casein kinase substrate phosphoprotein PP28 adh_short_C2 PF13561.6 CCF38061.1 - 2.2e-18 66.7 0.1 2.4e-18 66.6 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF38061.1 - 1.9e-13 50.3 0.1 2.4e-13 50.0 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase Kp4 PF09044.10 CCF38062.1 - 1.7e-44 150.9 0.7 2e-44 150.6 0.7 1.1 1 0 0 1 1 1 1 Kp4 MU117 PF15474.6 CCF38062.1 - 0.015 16.1 1.2 0.033 15.0 1.2 1.6 1 1 0 1 1 1 0 Meiotically up-regulated gene family PTR2 PF00854.21 CCF38063.1 - 4.8e-67 226.5 2.4 8.1e-67 225.8 2.4 1.4 1 0 0 1 1 1 1 POT family Sugar_tr PF00083.24 CCF38063.1 - 0.041 12.7 17.7 0.048 12.5 0.4 3.2 3 0 0 3 3 3 0 Sugar (and other) transporter zf-RanBP PF00641.18 CCF38064.1 - 2.5e-18 65.1 13.3 8.6e-11 41.0 1.6 2.3 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others RRM_1 PF00076.22 CCF38064.1 - 5.2e-08 32.6 0.0 1e-07 31.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNase_T PF00929.24 CCF38064.1 - 1.8e-06 28.6 0.0 2.7e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 Exonuclease HET PF06985.11 CCF38065.1 - 0.0045 17.3 1.0 0.0085 16.4 0.2 1.9 2 0 0 2 2 2 1 Heterokaryon incompatibility protein (HET) Ank_2 PF12796.7 CCF38065.1 - 0.12 12.9 0.0 0.37 11.4 0.0 1.8 1 1 0 1 1 1 0 Ankyrin repeats (3 copies) CBM-like PF14683.6 CCF38066.1 - 1.5e-34 119.2 0.0 2.9e-34 118.3 0.0 1.5 1 0 0 1 1 1 1 Polysaccharide lyase family 4, domain III fn3_3 PF14686.6 CCF38066.1 - 3.6e-07 29.9 0.7 1.1e-06 28.4 0.2 2.1 2 0 0 2 2 2 1 Polysaccharide lyase family 4, domain II CarboxypepD_reg PF13620.6 CCF38066.1 - 1.9e-06 28.1 0.6 0.0024 18.1 0.2 2.6 2 0 0 2 2 2 2 Carboxypeptidase regulatory-like domain Vps35 PF03635.17 CCF38068.1 - 0 1021.3 0.0 0 1021.1 0.0 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 Pkinase PF00069.25 CCF38070.1 - 8.9e-21 74.4 0.0 2e-14 53.6 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCF38070.1 - 4.6e-09 35.9 0.0 1.6e-05 24.3 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase DEK_C PF08766.11 CCF38070.1 - 0.021 14.7 0.3 0.068 13.1 0.0 1.9 2 0 0 2 2 2 0 DEK C terminal domain APC_N_CC PF16689.5 CCF38070.1 - 0.12 12.4 0.3 0.54 10.4 0.0 2.1 2 0 0 2 2 2 0 Coiled-coil N-terminus of APC, dimerisation domain Lipase_GDSL_2 PF13472.6 CCF38072.1 - 8e-15 55.7 0.5 1e-14 55.3 0.5 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 CCF38072.1 - 0.00018 21.5 0.0 0.00026 21.0 0.0 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase DHquinase_I PF01487.15 CCF38072.1 - 0.091 13.0 0.0 0.14 12.4 0.0 1.3 1 0 0 1 1 1 0 Type I 3-dehydroquinase DUF3328 PF11807.8 CCF38074.1 - 1e-38 133.3 0.2 1.4e-38 132.9 0.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) DUF3994 PF13159.6 CCF38075.1 - 0.0039 17.7 0.6 23 5.6 0.0 3.6 1 1 3 4 4 4 2 Domain of unknown function (DUF3994) DUF1515 PF07439.11 CCF38075.1 - 0.04 14.0 0.7 0.19 11.8 0.2 2.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1515) CBP_BcsF PF11120.8 CCF38075.1 - 0.048 13.8 0.8 52 4.1 0.0 3.5 4 0 0 4 4 4 0 Cellulose biosynthesis protein BcsF COX_ARM PF06481.14 CCF38075.1 - 0.13 12.2 0.1 34 4.4 0.0 2.9 3 0 0 3 3 3 0 COX Aromatic Rich Motif DUF1804 PF08822.11 CCF38075.1 - 0.13 12.2 0.7 1.9 8.5 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1804) SUN PF03856.13 CCF38076.1 - 1.3e-74 250.8 12.0 1.6e-74 250.4 12.0 1.1 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) Med13_C PF06333.12 CCF38076.1 - 1.2 8.3 9.9 1.8 7.7 9.9 1.3 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain PARM PF17061.5 CCF38076.1 - 5.8 7.0 30.1 9 6.3 30.1 1.2 1 0 0 1 1 1 0 PARM DUF4551 PF15087.6 CCF38076.1 - 7.3 5.3 9.2 10 4.8 9.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) PCI PF01399.27 CCF38077.1 - 0.005 17.3 0.0 0.077 13.5 0.0 2.3 2 0 0 2 2 2 1 PCI domain Thiolase_N PF00108.23 CCF38078.1 - 1.4e-87 293.4 0.5 2.2e-87 292.7 0.5 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 CCF38078.1 - 8.2e-37 125.6 1.5 1.3e-36 125.0 0.6 1.8 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 CCF38078.1 - 3.5e-05 23.5 0.6 9.1e-05 22.2 0.6 1.7 1 1 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain UQ_con PF00179.26 CCF38079.1 - 5.4e-52 175.2 0.1 6.1e-52 175.0 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 CCF38079.1 - 0.00062 19.5 0.0 0.00069 19.3 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 CCF38079.1 - 0.036 14.4 0.0 0.048 14.0 0.0 1.4 1 1 0 1 1 1 0 RWD domain Kinesin PF00225.23 CCF38080.1 - 3.7e-113 377.8 0.3 3.7e-113 377.8 0.3 1.9 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 CCF38080.1 - 3.6e-27 95.1 0.1 1.8e-26 92.9 0.1 2.3 1 0 0 1 1 1 1 Microtubule binding ERG2_Sigma1R PF04622.12 CCF38080.1 - 0.67 9.2 2.1 1.5 8.1 0.0 2.6 3 0 0 3 3 3 0 ERG2 and Sigma1 receptor like protein LAGLIDADG_WhiA PF14527.6 CCF38080.1 - 4.9 7.3 7.1 15 5.8 0.4 3.7 3 0 0 3 3 3 0 WhiA LAGLIDADG-like domain Mito_carr PF00153.27 CCF38081.1 - 0.015 15.2 0.1 5.3 7.0 0.0 2.4 2 0 0 2 2 2 0 Mitochondrial carrier protein Atthog PF18800.1 CCF38081.1 - 0.39 10.6 3.8 0.77 9.7 1.0 2.3 2 0 0 2 2 2 0 Attenuator of Hedgehog LCM PF04072.14 CCF38082.1 - 2.4e-19 70.0 0.0 8.4e-19 68.2 0.0 1.9 2 1 0 2 2 2 1 Leucine carboxyl methyltransferase F-box-like PF12937.7 CCF38083.1 - 0.0018 18.1 0.1 0.0036 17.2 0.1 1.6 1 0 0 1 1 1 1 F-box-like Metallophos PF00149.28 CCF38084.1 - 2.3e-10 41.3 0.7 5.3e-10 40.1 0.7 1.6 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase 5_nucleotid_C PF02872.18 CCF38084.1 - 0.089 13.0 0.0 0.19 11.9 0.0 1.5 1 0 0 1 1 1 0 5'-nucleotidase, C-terminal domain SnoaL_2 PF12680.7 CCF38085.1 - 6.7e-07 29.9 0.0 1e-06 29.3 0.0 1.2 1 0 0 1 1 1 1 SnoaL-like domain LigB PF02900.18 CCF38087.1 - 4.5e-33 114.5 0.0 5.2e-33 114.3 0.0 1.0 1 0 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase FAD_binding_3 PF01494.19 CCF38088.1 - 1.1e-21 77.5 0.2 1.7e-21 76.9 0.2 1.3 1 0 0 1 1 1 1 FAD binding domain ADC PF06314.11 CCF38088.1 - 8.7e-16 58.2 0.1 4.4e-15 55.9 0.1 1.9 1 1 0 1 1 1 1 Acetoacetate decarboxylase (ADC) FAD_binding_2 PF00890.24 CCF38088.1 - 8e-07 28.5 3.1 6e-06 25.6 1.9 2.3 2 0 0 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.6 CCF38088.1 - 1.4e-06 28.4 0.3 3.9e-06 27.0 0.3 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CCF38088.1 - 2.2e-06 27.1 0.1 3.6e-06 26.4 0.1 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 CCF38088.1 - 0.00013 21.4 1.3 0.00013 21.4 1.3 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase DAO PF01266.24 CCF38088.1 - 0.00015 21.5 3.5 0.00022 20.9 2.9 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.22 CCF38088.1 - 0.0014 17.8 0.5 0.0022 17.2 0.5 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A HI0933_like PF03486.14 CCF38088.1 - 0.0023 16.7 0.2 0.0033 16.2 0.2 1.2 1 0 0 1 1 1 1 HI0933-like protein Thi4 PF01946.17 CCF38088.1 - 0.0064 15.8 0.3 0.012 14.9 0.3 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.6 CCF38088.1 - 0.037 13.3 0.7 0.067 12.4 0.7 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 CCF38088.1 - 0.14 10.9 0.2 0.25 10.2 0.2 1.3 1 0 0 1 1 1 0 Tryptophan halogenase Pyr_redox PF00070.27 CCF38088.1 - 0.17 12.5 0.3 0.33 11.5 0.3 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DUF3873 PF12989.7 CCF38088.1 - 0.19 12.2 0.3 0.41 11.0 0.3 1.6 1 0 0 1 1 1 0 Domain of unknown function, B. Theta Gene description (DUF3873) AlaDh_PNT_C PF01262.21 CCF38088.1 - 0.23 10.8 0.6 0.42 9.9 0.6 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain DUF1279 PF06916.13 CCF38089.1 - 6.3e-25 87.5 0.0 3.5e-24 85.2 0.0 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF1279) DUF726 PF05277.12 CCF38090.1 - 7e-123 409.9 0.1 9.3e-123 409.5 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF726) Thioesterase PF00975.20 CCF38090.1 - 0.00087 19.5 0.0 0.0017 18.5 0.0 1.4 1 0 0 1 1 1 1 Thioesterase domain PE-PPE PF08237.11 CCF38090.1 - 0.05 13.1 0.0 0.1 12.1 0.0 1.4 1 0 0 1 1 1 0 PE-PPE domain Abhydrolase_6 PF12697.7 CCF38090.1 - 0.065 13.8 1.5 0.087 13.4 0.1 1.9 2 0 0 2 2 2 0 Alpha/beta hydrolase family Noc2 PF03715.13 CCF38091.1 - 2.6e-130 434.0 1.0 3.6e-130 433.6 1.0 1.2 1 0 0 1 1 1 1 Noc2p family Nop14 PF04147.12 CCF38091.1 - 0.0022 16.3 0.1 0.0022 16.3 0.1 2.2 1 1 1 2 2 2 1 Nop14-like family Cwf_Cwc_15 PF04889.12 CCF38091.1 - 0.024 14.4 15.7 0.032 13.9 15.7 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein RNA_pol_3_Rpc31 PF11705.8 CCF38091.1 - 0.12 12.6 23.8 0.18 12.0 23.8 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 NOA36 PF06524.12 CCF38091.1 - 1.2 8.3 17.6 1.7 7.9 17.6 1.2 1 0 0 1 1 1 0 NOA36 protein PPP4R2 PF09184.11 CCF38091.1 - 1.3 8.6 14.8 1.8 8.1 14.8 1.2 1 0 0 1 1 1 0 PPP4R2 TFIIA PF03153.13 CCF38091.1 - 3.6 7.5 15.5 5.6 6.9 15.5 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit BUD22 PF09073.10 CCF38091.1 - 4.1 6.6 19.3 5.5 6.2 19.3 1.2 1 0 0 1 1 1 0 BUD22 Astro_capsid_p PF12226.8 CCF38091.1 - 4.9 6.2 12.0 7.5 5.6 12.0 1.4 1 0 0 1 1 1 0 Turkey astrovirus capsid protein TauD PF02668.16 CCF38092.1 - 1.2e-26 94.1 1.3 1.8e-26 93.5 1.3 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family CsiD PF08943.10 CCF38092.1 - 0.021 13.9 0.0 0.035 13.2 0.0 1.2 1 0 0 1 1 1 0 CsiD Fungal_trans_2 PF11951.8 CCF38093.1 - 1.6e-09 37.1 0.0 1.2e-07 30.9 0.0 2.3 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF38093.1 - 2.1e-05 24.5 11.0 3.5e-05 23.8 11.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PP2C PF00481.21 CCF38094.1 - 3.3e-62 210.5 0.2 1.5e-51 175.5 0.3 3.0 1 1 1 2 2 2 2 Protein phosphatase 2C DUF1194 PF06707.11 CCF38094.1 - 0.092 11.9 0.5 0.16 11.2 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1194) Actin PF00022.19 CCF38095.1 - 4.6e-111 371.3 0.0 2.9e-110 368.7 0.0 1.8 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 CCF38095.1 - 0.032 13.0 0.0 0.23 10.2 0.0 2.1 1 1 0 1 1 1 0 MreB/Mbl protein Actin_micro PF17003.5 CCF38095.1 - 0.05 12.8 0.1 0.28 10.3 0.0 2.0 2 0 0 2 2 2 0 Putative actin-like family Cutinase PF01083.22 CCF38096.1 - 6.1e-32 111.0 0.0 1e-31 110.3 0.0 1.3 1 1 0 1 1 1 1 Cutinase DUF2235 PF09994.9 CCF38096.1 - 0.035 13.5 0.0 0.051 12.9 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized alpha/beta hydrolase domain (DUF2235) AA_permease PF00324.21 CCF38097.1 - 1.8e-124 416.0 36.6 2.2e-124 415.7 36.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CCF38097.1 - 3e-28 98.8 38.7 3.6e-28 98.5 38.7 1.0 1 0 0 1 1 1 1 Amino acid permease Erf4 PF10256.9 CCF38098.1 - 0.0008 19.5 0.0 0.0016 18.5 0.0 1.4 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family HET PF06985.11 CCF38099.1 - 2.4e-30 105.8 0.3 7.3e-30 104.2 0.0 2.0 2 1 0 2 2 2 1 Heterokaryon incompatibility protein (HET) FAD_binding_4 PF01565.23 CCF38100.1 - 1.4e-18 67.0 4.4 1.4e-18 67.0 4.4 1.9 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.12 CCF38100.1 - 3.1e-12 46.4 0.7 1.1e-11 44.7 0.1 2.0 2 0 0 2 2 2 1 Berberine and berberine like Sfi1 PF08457.10 CCF38101.1 - 0.0001 21.0 9.0 0.00013 20.6 9.0 1.2 1 0 0 1 1 1 1 Sfi1 spindle body protein DUF4724 PF15852.5 CCF38102.1 - 3.4 8.2 5.6 5 7.7 0.7 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4724) p450 PF00067.22 CCF38104.1 - 2.4e-58 198.0 0.0 3.2e-58 197.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 HAMP PF00672.25 CCF38105.1 - 3.3e-40 136.2 20.5 4.6e-08 33.3 0.4 7.8 7 0 0 7 7 7 6 HAMP domain HATPase_c PF02518.26 CCF38105.1 - 1.1e-30 106.4 0.0 5e-30 104.3 0.0 2.2 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CCF38105.1 - 1.1e-26 93.2 0.9 8.7e-26 90.3 0.3 2.7 2 0 0 2 2 2 1 Response regulator receiver domain HisKA PF00512.25 CCF38105.1 - 7.7e-17 61.1 0.5 7.7e-17 61.1 0.5 4.0 5 0 0 5 5 4 1 His Kinase A (phospho-acceptor) domain Syntaxin_2 PF14523.6 CCF38105.1 - 2.7e-07 30.9 17.1 1.1 9.6 0.1 7.6 2 1 4 7 7 7 4 Syntaxin-like protein GLE1 PF07817.13 CCF38105.1 - 9.4e-05 21.7 3.5 1.7 7.8 0.1 4.6 2 1 2 4 4 4 3 GLE1-like protein Fib_alpha PF08702.10 CCF38105.1 - 0.00017 21.8 33.3 0.084 13.1 0.8 7.5 7 1 1 8 8 8 2 Fibrinogen alpha/beta chain family DUF4279 PF14106.6 CCF38105.1 - 0.0014 18.8 0.0 46 4.3 0.0 5.4 6 0 0 6 6 5 0 Domain of unknown function (DUF4279) DUF948 PF06103.11 CCF38105.1 - 0.0016 18.7 46.2 0.23 11.7 1.3 9.6 4 3 2 6 6 6 3 Bacterial protein of unknown function (DUF948) DUF4795 PF16043.5 CCF38105.1 - 0.015 14.9 26.8 0.51 9.9 0.1 5.9 1 1 1 4 4 4 0 Domain of unknown function (DUF4795) Laminin_II PF06009.12 CCF38105.1 - 0.027 14.5 38.3 0.44 10.6 0.2 7.8 7 1 1 8 8 8 0 Laminin Domain II DUF3829 PF12889.7 CCF38105.1 - 0.031 13.8 11.0 1.2 8.5 0.1 5.0 4 2 1 5 5 5 0 Protein of unknown function (DUF3829) DUF1759 PF03564.15 CCF38105.1 - 0.032 14.2 0.3 46 3.9 0.1 4.3 4 0 0 4 4 4 0 Protein of unknown function (DUF1759) TPR_MLP1_2 PF07926.12 CCF38107.1 - 0.0035 17.4 19.4 0.0035 17.4 19.4 2.1 1 1 1 2 2 2 1 TPR/MLP1/MLP2-like protein Fez1 PF06818.15 CCF38107.1 - 0.012 16.1 15.1 0.012 16.1 15.1 1.7 1 1 1 2 2 2 0 Fez1 Atg14 PF10186.9 CCF38107.1 - 7.9 5.5 11.8 13 4.7 11.8 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 ADIP PF11559.8 CCF38107.1 - 8.7 6.4 21.6 1.9 8.6 6.0 2.5 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding LrgA PF03788.14 CCF38108.1 - 0.036 14.0 7.3 0.027 14.4 3.8 2.1 1 1 1 2 2 2 0 LrgA family C5HCH PF17982.1 CCF38109.1 - 0.34 11.1 3.5 0.68 10.1 3.5 1.4 1 0 0 1 1 1 0 NSD Cys-His rich domain Corona_S2 PF01601.16 CCF38110.1 - 0.042 12.4 16.6 0.056 11.9 16.6 1.1 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein Tannase PF07519.11 CCF38111.1 - 3.3e-88 296.6 0.3 4.5e-88 296.2 0.3 1.2 1 0 0 1 1 1 1 Tannase and feruloyl esterase MFS_1 PF07690.16 CCF38113.1 - 7.2e-05 21.9 0.2 9.2e-05 21.5 0.2 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_1 PF07690.16 CCF38114.1 - 4.5e-06 25.8 0.1 6.2e-06 25.4 0.1 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Cu_amine_oxid PF01179.20 CCF38115.1 - 0.039 12.9 0.1 0.063 12.2 0.1 1.2 1 0 0 1 1 1 0 Copper amine oxidase, enzyme domain Sugar_tr PF00083.24 CCF38117.1 - 6.1e-101 338.5 29.1 7.5e-101 338.2 29.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF38117.1 - 6.5e-34 117.4 29.9 6.5e-34 117.4 29.9 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 CCF38117.1 - 5.8e-05 21.7 3.5 0.00011 20.7 3.5 1.4 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) PT-VENN PF04829.13 CCF38117.1 - 0.018 15.1 1.1 0.054 13.6 1.1 1.8 1 0 0 1 1 1 0 Pre-toxin domain with VENN motif DUF1385 PF07136.11 CCF38117.1 - 0.36 10.1 4.1 0.99 8.7 1.4 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1385) PHA_synth_III_E PF09712.10 CCF38118.1 - 0.069 12.2 0.3 0.11 11.6 0.3 1.3 1 0 0 1 1 1 0 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E) Erv26 PF04148.13 CCF38119.1 - 2.6e-52 177.7 0.1 3e-52 177.5 0.1 1.0 1 0 0 1 1 1 1 Transmembrane adaptor Erv26 DUF3377 PF11857.8 CCF38119.1 - 0.1 12.5 0.0 0.19 11.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) AflR PF08493.10 CCF38120.1 - 1 8.7 6.2 1.2 8.5 6.2 1.0 1 0 0 1 1 1 0 Aflatoxin regulatory protein adh_short PF00106.25 CCF38121.1 - 6e-25 87.8 0.0 7.7e-21 74.4 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCF38121.1 - 1e-13 51.4 0.0 6.1e-13 48.9 0.0 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Polysacc_synt_2 PF02719.15 CCF38121.1 - 0.002 17.4 0.0 0.0026 17.0 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Vac14_Fab1_bd PF12755.7 CCF38123.1 - 3.1e-44 149.5 0.0 7.9e-43 145.0 0.0 2.2 2 0 0 2 2 2 1 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 CCF38123.1 - 1.1e-08 35.4 0.4 3.6e-05 24.2 0.1 3.5 3 0 0 3 3 3 2 HEAT-like repeat HEAT PF02985.22 CCF38123.1 - 1.6e-05 24.7 3.8 0.0002 21.3 0.0 3.7 5 0 0 5 5 5 1 HEAT repeat Cnd1 PF12717.7 CCF38123.1 - 0.00075 19.6 0.0 0.3 11.1 0.0 2.5 2 0 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 CCF38123.1 - 0.0044 17.4 0.2 0.071 13.5 0.0 2.7 3 0 0 3 3 3 1 HEAT repeats Arm PF00514.23 CCF38123.1 - 0.051 13.6 0.0 0.24 11.5 0.0 2.2 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat Aldo_ket_red PF00248.21 CCF38124.1 - 1.5e-43 149.1 0.0 1.6e-42 145.7 0.0 1.9 1 1 0 1 1 1 1 Aldo/keto reductase family CENP-B_dimeris PF09026.10 CCF38125.1 - 0.002 18.5 9.8 0.0051 17.2 9.8 1.6 1 0 0 1 1 1 1 Centromere protein B dimerisation domain DUF2457 PF10446.9 CCF38125.1 - 0.014 14.5 7.7 0.024 13.8 7.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Sigma70_ner PF04546.13 CCF38125.1 - 0.092 12.6 3.7 0.19 11.6 3.7 1.4 1 0 0 1 1 1 0 Sigma-70, non-essential region RXT2_N PF08595.11 CCF38125.1 - 0.18 11.8 3.6 0.37 10.8 3.6 1.4 1 0 0 1 1 1 0 RXT2-like, N-terminal Cwf_Cwc_15 PF04889.12 CCF38125.1 - 0.21 11.3 10.4 0.39 10.4 10.4 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein RRN3 PF05327.11 CCF38125.1 - 0.59 8.6 3.7 0.85 8.1 3.7 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DNA_pol_phi PF04931.13 CCF38125.1 - 1.1 7.3 11.5 1.6 6.8 10.2 1.7 2 0 0 2 2 2 0 DNA polymerase phi GCIP PF13324.6 CCF38125.1 - 4.6 6.8 5.6 8.4 5.9 5.6 1.3 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting Pkinase PF00069.25 CCF38126.1 - 2e-64 217.5 0.0 3e-64 217.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF38126.1 - 2.5e-43 148.3 0.0 3.8e-43 147.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 CCF38126.1 - 9e-18 64.4 0.0 3.1e-17 62.7 0.0 2.0 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.6 CCF38126.1 - 2.5e-07 30.3 1.6 2.9e-07 30.1 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 CCF38126.1 - 7.7e-07 28.2 0.0 1.8e-06 27.0 0.0 1.6 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 CCF38126.1 - 0.0058 15.6 0.0 0.013 14.5 0.0 1.5 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 CCF38126.1 - 0.021 14.2 0.1 0.17 11.2 0.0 2.1 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CCF38126.1 - 0.033 14.1 0.5 0.24 11.3 0.0 2.4 2 1 0 2 2 2 0 Phosphotransferase enzyme family FTA2 PF13095.6 CCF38126.1 - 0.21 11.2 0.8 0.51 9.9 0.0 2.0 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 AAA PF00004.29 CCF38127.1 - 1.2e-17 64.6 0.0 2.3e-17 63.7 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CCF38127.1 - 0.00012 22.6 0.1 0.00055 20.4 0.1 2.0 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 CCF38127.1 - 0.031 14.6 0.5 0.3 11.4 0.3 2.3 1 1 1 2 2 2 0 AAA domain AAA_5 PF07728.14 CCF38127.1 - 0.037 14.0 0.0 0.093 12.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) CPT PF07931.12 CCF38127.1 - 0.1 12.4 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein GAGA_bind PF06217.12 CCF38127.1 - 1 9.6 12.8 1.7 8.8 12.8 1.4 1 0 0 1 1 1 0 GAGA binding protein-like family SURF4 PF02077.15 CCF38128.1 - 2e-98 329.2 8.4 2.3e-98 329.1 8.4 1.0 1 0 0 1 1 1 1 SURF4 family Halogen_Hydrol PF10112.9 CCF38128.1 - 3.5 7.6 6.5 15 5.5 1.9 2.7 3 0 0 3 3 3 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein zf-C2H2 PF00096.26 CCF38131.1 - 2.6e-20 71.6 31.2 4.1e-06 26.9 0.2 4.7 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CCF38131.1 - 6.1e-18 64.4 28.6 2.2e-06 27.8 0.6 5.1 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 CCF38131.1 - 2.8e-09 37.0 27.9 0.013 16.2 1.2 4.8 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CCF38131.1 - 0.00015 21.9 3.2 0.51 10.7 0.5 4.2 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-C2H2_8 PF15909.5 CCF38131.1 - 0.007 16.6 9.6 0.97 9.8 6.5 2.7 1 1 1 2 2 2 2 C2H2-type zinc ribbon zf-C2H2_11 PF16622.5 CCF38131.1 - 0.015 15.0 2.0 0.015 15.0 2.0 2.5 2 0 0 2 2 2 0 zinc-finger C2H2-type FOXP-CC PF16159.5 CCF38131.1 - 0.021 15.4 10.3 7.4 7.3 0.3 4.8 2 1 2 4 4 4 0 FOXP coiled-coil domain zf-TRAF PF02176.18 CCF38131.1 - 0.033 14.9 2.3 0.033 14.9 2.3 3.3 1 1 2 3 3 3 0 TRAF-type zinc finger zf-met PF12874.7 CCF38131.1 - 0.036 14.5 1.0 0.036 14.5 1.0 4.6 5 1 1 6 6 6 0 Zinc-finger of C2H2 type zf-C2H2_aberr PF17017.5 CCF38131.1 - 8.1 6.6 11.3 3.1 7.9 0.1 3.4 1 1 2 3 3 3 0 Aberrant zinc-finger CFEM PF05730.11 CCF38132.1 - 8.4e-14 51.4 6.7 1.5e-13 50.7 6.7 1.4 1 0 0 1 1 1 1 CFEM domain RhodobacterPufX PF11511.8 CCF38132.1 - 3.2 7.4 5.9 30 4.3 0.3 2.9 2 0 0 2 2 2 0 Intrinsic membrane protein PufX UPF0182 PF03699.13 CCF38132.1 - 8.3 4.4 9.1 4.8 5.2 7.2 1.6 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0182) p450 PF00067.22 CCF38133.1 - 3.4e-68 230.5 0.0 4.2e-68 230.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 NmrA PF05368.13 CCF38134.1 - 3.3e-17 62.8 0.2 4.1e-17 62.5 0.2 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CCF38134.1 - 5.3e-10 39.5 0.7 6.8e-10 39.1 0.1 1.5 2 0 0 2 2 2 1 NAD(P)H-binding Epimerase PF01370.21 CCF38134.1 - 7.4e-06 25.6 0.2 1.9e-05 24.2 0.1 1.7 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family KR PF08659.10 CCF38134.1 - 1.9e-05 24.7 0.0 3e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 KR domain LpxI_N PF17930.1 CCF38134.1 - 0.00042 20.2 0.1 0.00083 19.3 0.1 1.4 1 0 0 1 1 1 1 LpxI N-terminal domain NAD_binding_4 PF07993.12 CCF38134.1 - 0.0076 15.4 0.0 0.014 14.6 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein CoA_binding_3 PF13727.6 CCF38134.1 - 0.0092 16.0 0.1 0.014 15.4 0.1 1.3 1 0 0 1 1 1 1 CoA-binding domain 3Beta_HSD PF01073.19 CCF38134.1 - 0.018 14.1 0.1 0.026 13.5 0.1 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 CCF38134.1 - 0.022 13.9 0.0 0.032 13.3 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein adh_short PF00106.25 CCF38134.1 - 0.04 13.4 0.1 0.068 12.6 0.1 1.4 1 0 0 1 1 1 0 short chain dehydrogenase DapB_N PF01113.20 CCF38134.1 - 0.11 12.6 0.4 0.58 10.3 0.3 2.1 1 1 1 2 2 2 0 Dihydrodipicolinate reductase, N-terminus TrkA_N PF02254.18 CCF38134.1 - 0.12 12.6 0.4 0.2 11.9 0.4 1.4 1 0 0 1 1 1 0 TrkA-N domain zf-C2H2_4 PF13894.6 CCF38135.1 - 1.2e-06 28.8 13.9 0.058 14.3 0.9 3.8 3 1 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_2 PF12756.7 CCF38135.1 - 3.8e-05 24.0 7.0 0.023 15.0 0.8 3.1 2 1 1 3 3 3 2 C2H2 type zinc-finger (2 copies) zf-C2H2_6 PF13912.6 CCF38135.1 - 0.00039 20.3 4.6 0.00048 20.1 2.0 2.4 2 0 0 2 2 2 1 C2H2-type zinc finger zf-met PF12874.7 CCF38135.1 - 0.00075 19.8 14.4 0.003 17.9 1.9 4.2 4 0 0 4 4 4 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 CCF38135.1 - 0.00086 19.5 0.6 0.00086 19.5 0.6 3.6 4 0 0 4 4 4 1 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 CCF38135.1 - 0.0017 18.7 19.3 0.16 12.5 2.4 3.8 4 0 0 4 4 4 2 Zinc finger, C2H2 type OTT_1508_deam PF14441.6 CCF38135.1 - 0.022 14.8 0.9 0.022 14.8 0.9 2.1 2 1 0 2 2 2 0 OTT_1508-like deaminase zf-H2C2_2 PF13465.6 CCF38135.1 - 0.04 14.4 17.0 1.4 9.5 1.1 3.6 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2H2_11 PF16622.5 CCF38135.1 - 0.075 12.8 1.2 0.075 12.8 1.2 2.2 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-Di19 PF05605.12 CCF38135.1 - 0.085 13.2 0.8 0.085 13.2 0.8 2.8 2 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Rad50_zn_hook PF04423.14 CCF38135.1 - 0.24 11.3 3.0 0.85 9.5 0.0 2.6 3 0 0 3 3 3 0 Rad50 zinc hook motif zf-C2H2_9 PF16293.5 CCF38135.1 - 0.27 11.1 5.1 5.9 6.8 0.4 3.3 2 1 1 3 3 3 0 C2H2 type zinc-finger (1 copy) zf_ZIC PF18366.1 CCF38135.1 - 3.3 7.9 5.9 12 6.1 0.1 2.9 3 0 0 3 3 3 0 Zic proteins zinc finger domain TFX_C PF14601.6 CCF38136.1 - 0.027 14.5 0.0 0.33 11.0 0.0 2.4 3 0 0 3 3 3 0 DNA_binding protein, TFX, C-term Abdominal-A PF12407.8 CCF38136.1 - 0.046 13.3 1.4 0.078 12.6 1.4 1.3 1 0 0 1 1 1 0 Homeobox protein TPR_2 PF07719.17 CCF38137.1 - 0.00053 19.9 10.1 0.0091 16.0 1.6 3.5 4 0 0 4 4 4 2 Tetratricopeptide repeat SET PF00856.28 CCF38137.1 - 0.0024 18.3 0.2 0.0069 16.8 0.1 1.8 2 0 0 2 2 2 1 SET domain TPR_9 PF13371.6 CCF38137.1 - 0.0034 17.5 0.6 0.089 12.9 0.0 2.7 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 CCF38137.1 - 0.011 15.9 1.0 0.058 13.6 0.6 2.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 CCF38137.1 - 0.017 15.8 8.8 0.089 13.5 0.6 2.9 1 1 2 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 CCF38137.1 - 0.028 14.2 0.8 6.4 6.8 0.7 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat CENP-L PF13092.6 CCF38137.1 - 0.06 13.6 0.0 0.1 12.8 0.0 1.3 1 0 0 1 1 1 0 Kinetochore complex Sim4 subunit Fta1 TPR_11 PF13414.6 CCF38137.1 - 0.068 12.9 0.9 0.38 10.5 0.0 2.5 2 0 0 2 2 2 0 TPR repeat UCR_hinge PF02320.16 CCF38137.1 - 0.53 10.5 1.6 0.53 10.5 0.2 1.7 2 0 0 2 2 2 0 Ubiquinol-cytochrome C reductase hinge protein MutS_V PF00488.21 CCF38138.1 - 4.1e-70 235.7 0.4 1.2e-69 234.2 0.1 1.9 2 0 0 2 2 2 1 MutS domain V MutS_III PF05192.18 CCF38138.1 - 1.9e-35 122.8 2.1 4.4e-35 121.6 2.1 1.6 1 0 0 1 1 1 1 MutS domain III MutS_IV PF05190.18 CCF38138.1 - 0.00028 21.2 0.0 0.00072 19.9 0.0 1.7 1 0 0 1 1 1 1 MutS family domain IV MutS_II PF05188.17 CCF38138.1 - 0.0028 17.9 0.0 0.018 15.3 0.0 2.4 2 0 0 2 2 2 1 MutS domain II DUF4911 PF16256.5 CCF38138.1 - 0.016 15.2 0.1 0.04 13.9 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4911) AAA_27 PF13514.6 CCF38138.1 - 0.037 13.6 0.0 0.098 12.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 CCF38138.1 - 0.19 11.5 0.1 0.58 9.9 0.1 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain GFO_IDH_MocA PF01408.22 CCF38141.1 - 2.7e-24 86.3 0.0 4.2e-24 85.7 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 CCF38141.1 - 1.4e-16 60.6 0.0 2.5e-16 59.7 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain NAD_binding_3 PF03447.16 CCF38141.1 - 0.046 14.4 0.0 0.11 13.2 0.0 1.6 2 0 0 2 2 2 0 Homoserine dehydrogenase, NAD binding domain Methyltransf_23 PF13489.6 CCF38142.1 - 4.1e-13 49.5 0.0 5.7e-13 49.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF38142.1 - 1.6e-09 38.3 0.0 4.7e-09 36.9 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF38142.1 - 2e-07 31.5 0.0 4.6e-07 30.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCF38142.1 - 0.00019 20.8 0.0 0.00063 19.2 0.0 1.7 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 CCF38142.1 - 0.00088 19.1 0.0 0.019 14.8 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 CCF38142.1 - 0.0022 18.1 0.0 0.0032 17.6 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_12 PF08242.12 CCF38142.1 - 0.0025 18.5 0.0 0.0095 16.7 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 CCF38142.1 - 0.038 13.8 0.0 8 6.2 0.0 2.3 2 0 0 2 2 2 0 Hypothetical methyltransferase F-box-like PF12937.7 CCF38143.1 - 1.8e-06 27.7 0.8 3.5e-06 26.8 0.1 2.0 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 CCF38143.1 - 0.0011 18.7 0.0 0.0033 17.3 0.0 1.8 1 0 0 1 1 1 1 F-box domain HET PF06985.11 CCF38144.1 - 2.7e-26 92.7 0.0 4.8e-26 91.9 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) MaoC_dehydrat_N PF13452.6 CCF38146.1 - 0.0012 18.9 0.0 0.005 17.0 0.0 1.9 2 0 0 2 2 2 1 N-terminal half of MaoC dehydratase DUF1929 PF09118.11 CCF38146.1 - 0.056 13.8 0.0 0.13 12.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1929) GATase_6 PF13522.6 CCF38148.1 - 1.1e-11 45.0 0.0 2.3e-11 44.0 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain Pribosyltran PF00156.27 CCF38148.1 - 6.4e-08 32.3 0.0 1.3e-07 31.3 0.0 1.5 1 0 0 1 1 1 1 Phosphoribosyl transferase domain GATase_7 PF13537.6 CCF38148.1 - 2.9e-07 30.4 0.0 6.6e-07 29.3 0.0 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase domain ADH_zinc_N PF00107.26 CCF38148.1 - 0.03 14.3 0.0 11 6.0 0.0 2.7 2 0 0 2 2 2 0 Zinc-binding dehydrogenase HET PF06985.11 CCF38149.1 - 2e-25 89.9 0.0 1e-23 84.3 0.0 2.1 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) RTA1 PF04479.13 CCF38150.1 - 6.5e-62 208.8 16.3 6.5e-62 208.8 16.3 1.6 1 1 1 2 2 2 1 RTA1 like protein MHYT PF03707.16 CCF38150.1 - 0.15 12.2 0.2 0.15 12.2 0.2 3.3 3 1 1 4 4 4 0 Bacterial signalling protein N terminal repeat MFS_1 PF07690.16 CCF38151.1 - 1.7e-19 70.0 11.5 2.4e-19 69.5 11.5 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF38151.1 - 3.6e-09 36.0 7.8 4.2e-09 35.8 7.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1_like PF12832.7 CCF38151.1 - 0.0042 16.0 8.0 0.0053 15.7 8.0 1.1 1 0 0 1 1 1 1 MFS_1 like family TRI12 PF06609.13 CCF38151.1 - 0.034 12.6 2.7 0.042 12.2 2.7 1.1 1 0 0 1 1 1 0 Fungal trichothecene efflux pump (TRI12) zf-RNPHF PF08080.12 CCF38151.1 - 0.11 12.5 0.0 16 5.6 0.0 2.5 2 0 0 2 2 2 0 RNPHF zinc finger AMP-binding PF00501.28 CCF38152.1 - 3.6e-18 65.4 0.0 4.2e-18 65.2 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme Amidohydro_2 PF04909.14 CCF38153.1 - 9.1e-44 150.4 0.2 1e-43 150.2 0.2 1.0 1 0 0 1 1 1 1 Amidohydrolase Y_phosphatase PF00102.27 CCF38154.1 - 1e-60 205.3 0.1 7.9e-33 114.0 0.0 3.2 3 0 0 3 3 3 3 Protein-tyrosine phosphatase Rhodanese PF00581.20 CCF38154.1 - 4e-12 46.6 0.0 1.1e-11 45.1 0.0 1.8 1 0 0 1 1 1 1 Rhodanese-like domain DSPc PF00782.20 CCF38154.1 - 0.022 14.6 0.1 0.055 13.3 0.1 1.6 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 CCF38154.1 - 0.052 13.5 0.2 0.11 12.4 0.2 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family AAA PF00004.29 CCF38155.1 - 7.7e-44 149.3 0.0 1.3e-43 148.6 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CCF38155.1 - 2.3e-14 52.9 0.0 4.3e-14 52.0 0.0 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 CCF38155.1 - 1.1e-07 31.9 0.0 2.7e-07 30.7 0.0 1.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 CCF38155.1 - 1.4e-07 31.8 0.0 2.6e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 CCF38155.1 - 4.4e-06 27.2 0.0 0.00011 22.6 0.0 2.6 2 1 0 3 3 3 1 AAA ATPase domain Prot_ATP_ID_OB PF16450.5 CCF38155.1 - 2.4e-05 24.2 3.4 6.4e-05 22.8 3.4 1.8 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_22 PF13401.6 CCF38155.1 - 2.5e-05 24.5 0.2 0.006 16.9 0.2 2.4 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 CCF38155.1 - 5.8e-05 22.9 0.0 0.00011 22.0 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 CCF38155.1 - 0.00057 20.4 0.0 0.019 15.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.13 CCF38155.1 - 0.001 18.4 0.0 0.002 17.4 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_33 PF13671.6 CCF38155.1 - 0.0015 18.7 0.0 0.0029 17.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain Prot_ATP_OB_N PF17758.1 CCF38155.1 - 0.0026 17.3 0.1 0.0088 15.7 0.1 1.9 1 0 0 1 1 1 1 Proteasomal ATPase OB N-terminal domain IstB_IS21 PF01695.17 CCF38155.1 - 0.0029 17.4 0.0 0.0052 16.5 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_3 PF07726.11 CCF38155.1 - 0.0032 17.3 0.0 0.01 15.7 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 CCF38155.1 - 0.008 15.6 0.0 0.017 14.5 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI ATPase PF06745.13 CCF38155.1 - 0.0085 15.5 0.0 0.019 14.3 0.0 1.6 1 0 0 1 1 1 1 KaiC TsaE PF02367.17 CCF38155.1 - 0.011 15.8 0.0 0.02 14.9 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 CCF38155.1 - 0.011 16.0 0.0 0.02 15.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 CCF38155.1 - 0.021 14.0 0.0 0.038 13.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Sigma54_activat PF00158.26 CCF38155.1 - 0.023 14.4 0.0 0.097 12.4 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_7 PF12775.7 CCF38155.1 - 0.027 14.0 0.0 0.044 13.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region PhoH PF02562.16 CCF38155.1 - 0.029 13.8 0.0 0.14 11.6 0.0 2.0 2 0 0 2 2 2 0 PhoH-like protein AAA_24 PF13479.6 CCF38155.1 - 0.032 14.0 0.0 0.1 12.3 0.0 1.8 3 0 0 3 3 2 0 AAA domain RNA_helicase PF00910.22 CCF38155.1 - 0.034 14.5 0.0 0.064 13.6 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_14 PF13173.6 CCF38155.1 - 0.034 14.2 0.0 0.059 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain HR1 PF02185.16 CCF38155.1 - 0.052 13.7 1.0 0.13 12.4 1.0 1.6 1 0 0 1 1 1 0 Hr1 repeat AAA_25 PF13481.6 CCF38155.1 - 0.054 13.1 0.1 0.17 11.5 0.0 1.8 2 0 0 2 2 2 0 AAA domain Parvo_NS1 PF01057.17 CCF38155.1 - 0.058 12.5 0.0 0.1 11.7 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 DUF2072 PF09845.9 CCF38155.1 - 0.084 13.1 0.1 0.17 12.2 0.1 1.5 1 0 0 1 1 1 0 Zn-ribbon containing protein Zeta_toxin PF06414.12 CCF38155.1 - 0.11 11.8 0.0 0.19 11.0 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin Na_Ca_ex PF01699.24 CCF38156.1 - 9.1e-22 77.6 29.2 2.9e-14 53.3 13.9 3.5 5 0 0 5 5 5 2 Sodium/calcium exchanger protein YccF PF03733.13 CCF38156.1 - 1.1e-16 61.3 11.4 1.1e-16 61.3 11.4 4.2 3 0 0 3 3 3 2 Inner membrane component domain Oxidored_molyb PF00174.19 CCF38157.1 - 2.7e-50 170.3 0.0 4.1e-50 169.8 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.16 CCF38157.1 - 1.2e-18 67.4 0.3 2.2e-18 66.6 0.3 1.4 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain GHMP_kinases_C PF08544.13 CCF38158.1 - 6.3e-05 23.3 0.0 9e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 GHMP kinases C terminal PfkB PF00294.24 CCF38159.1 - 4.1e-11 42.7 0.0 9.3e-11 41.6 0.0 1.5 1 1 0 1 1 1 1 pfkB family carbohydrate kinase STPPase_N PF16891.5 CCF38160.1 - 3.2e-17 62.7 0.0 5.7e-17 61.9 0.0 1.4 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Metallophos PF00149.28 CCF38160.1 - 7.1e-11 43.0 0.0 9.2e-09 36.1 0.0 2.2 1 1 1 2 2 2 2 Calcineurin-like phosphoesterase TauD PF02668.16 CCF38161.1 - 1.2e-54 185.9 2.2 1.6e-54 185.5 2.2 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family RMI2 PF16100.5 CCF38161.1 - 0.18 11.6 0.0 0.32 10.8 0.0 1.4 1 0 0 1 1 1 0 RecQ-mediated genome instability protein 2 MFS_1 PF07690.16 CCF38162.1 - 5e-30 104.6 26.2 6.6e-30 104.2 17.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 CCF38162.1 - 4.9e-06 25.7 0.8 4.9e-06 25.7 0.8 2.7 2 2 0 2 2 2 1 MFS_1 like family Fungal_trans_2 PF11951.8 CCF38163.1 - 3.7e-11 42.5 0.0 1.7e-10 40.3 0.0 2.0 2 0 0 2 2 2 1 Fungal specific transcription factor domain Rax2 PF12768.7 CCF38164.1 - 1.9e-74 249.8 0.2 7.4e-74 247.8 0.0 2.1 3 0 0 3 3 3 1 Cortical protein marker for cell polarity HLH PF00010.26 CCF38168.1 - 4.1e-12 45.9 2.1 6.8e-12 45.2 1.2 1.9 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain NRBF2 PF08961.10 CCF38168.1 - 0.00084 19.0 4.1 0.0016 18.1 4.1 1.4 1 0 0 1 1 1 1 Nuclear receptor-binding factor 2, autophagy regulator KLRAQ PF10205.9 CCF38168.1 - 0.014 15.6 0.6 0.033 14.4 0.6 1.5 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein Rootletin PF15035.6 CCF38168.1 - 0.038 14.0 8.7 0.079 13.0 8.7 1.5 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion HALZ PF02183.18 CCF38168.1 - 0.072 13.3 0.6 0.14 12.4 0.6 1.5 1 0 0 1 1 1 0 Homeobox associated leucine zipper DUF4776 PF16003.5 CCF38168.1 - 0.13 11.3 1.7 0.18 10.7 1.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) Phage_GPO PF05929.11 CCF38168.1 - 0.25 10.9 3.8 0.47 10.0 3.8 1.3 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase DivIC PF04977.15 CCF38168.1 - 0.29 10.9 1.2 0.85 9.4 0.7 2.0 2 0 0 2 2 2 0 Septum formation initiator YabA PF06156.13 CCF38168.1 - 0.81 10.4 3.3 1.2 9.8 2.1 1.9 1 1 0 1 1 1 0 Initiation control protein YabA GIT_CC PF16559.5 CCF38168.1 - 1.5 8.7 7.1 2.1 8.3 0.9 2.4 1 1 1 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor RRM_1 PF00076.22 CCF38170.1 - 2.4e-14 52.9 0.0 6.3e-14 51.6 0.0 1.7 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CCF38170.1 - 0.065 12.8 0.0 0.095 12.3 0.0 1.2 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1866 PF08952.11 CCF38170.1 - 0.2 11.5 0.0 0.38 10.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1866) Peptidase_M43 PF05572.13 CCF38171.1 - 1.9e-17 63.6 0.0 4e-17 62.6 0.0 1.5 2 0 0 2 2 2 1 Pregnancy-associated plasma protein-A Reprolysin_3 PF13582.6 CCF38171.1 - 0.0019 18.7 0.0 0.0031 18.0 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 CCF38171.1 - 0.0049 16.8 0.0 0.0081 16.1 0.0 1.4 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like DUF4953 PF16313.5 CCF38171.1 - 0.013 14.7 0.1 0.019 14.2 0.1 1.2 1 0 0 1 1 1 0 Met-zincin Reprolysin_5 PF13688.6 CCF38171.1 - 0.03 14.5 0.0 0.041 14.0 0.0 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12 NAD_binding_8 PF13450.6 CCF38174.1 - 2.9e-09 37.0 0.0 3.2e-09 36.9 0.0 1.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 CCF38174.1 - 4.6e-07 29.9 0.0 5e-07 29.8 0.0 1.0 1 0 0 1 1 1 1 FAD-NAD(P)-binding DAO PF01266.24 CCF38174.1 - 0.00011 21.9 0.2 0.00012 21.8 0.2 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCF38174.1 - 0.00016 21.0 0.0 0.00016 21.0 0.0 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 CCF38174.1 - 0.0002 20.8 0.1 0.00022 20.6 0.1 1.0 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase Thi4 PF01946.17 CCF38174.1 - 0.0004 19.7 0.1 0.00041 19.7 0.1 1.0 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.14 CCF38174.1 - 0.00047 19.0 0.1 0.00051 18.9 0.1 1.0 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_3 PF01494.19 CCF38174.1 - 0.00073 18.9 0.0 0.00073 18.9 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain MCRA PF06100.11 CCF38174.1 - 0.0044 15.9 0.0 0.0046 15.8 0.0 1.0 1 0 0 1 1 1 1 MCRA family FAD_oxidored PF12831.7 CCF38174.1 - 0.032 13.6 0.1 0.035 13.5 0.1 1.0 1 0 0 1 1 1 0 FAD dependent oxidoreductase Trp_halogenase PF04820.14 CCF38174.1 - 0.087 11.7 0.1 0.091 11.6 0.1 1.0 1 0 0 1 1 1 0 Tryptophan halogenase FAD_binding_2 PF00890.24 CCF38174.1 - 0.17 10.9 0.4 0.17 11.0 0.4 1.0 1 0 0 1 1 1 0 FAD binding domain FMO-like PF00743.19 CCF38174.1 - 0.18 10.2 0.0 0.18 10.2 0.0 1.0 1 0 0 1 1 1 0 Flavin-binding monooxygenase-like Shikimate_DH PF01488.20 CCF38174.1 - 0.2 11.7 0.0 0.2 11.7 0.0 1.1 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase GIDA PF01134.22 CCF38174.1 - 0.23 10.5 0.2 0.21 10.6 0.2 1.0 1 0 0 1 1 1 0 Glucose inhibited division protein A MFS_1 PF07690.16 CCF38175.1 - 5.6e-35 120.9 29.5 5.9e-34 117.5 31.1 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily DUF2964 PF11177.8 CCF38175.1 - 9.7 6.5 6.8 4.6 7.5 0.1 3.2 3 1 0 3 3 3 0 Protein of unknown function (DUF2964) MFS_1 PF07690.16 CCF38176.1 - 4.4e-46 157.4 37.6 7.1e-46 156.7 37.6 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF38176.1 - 6.3e-14 51.7 4.9 6.3e-14 51.7 4.9 1.8 2 1 0 2 2 2 1 Sugar (and other) transporter MFS_4 PF06779.14 CCF38176.1 - 1.2e-06 28.1 3.6 1.2e-06 28.1 3.6 2.5 3 0 0 3 3 3 1 Uncharacterised MFS-type transporter YbfB SMN PF06003.12 CCF38176.1 - 0.19 11.0 1.8 0.29 10.3 1.8 1.3 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) Transglut_core PF01841.19 CCF38177.1 - 9.1e-09 35.8 0.0 1.9e-08 34.7 0.0 1.6 1 0 0 1 1 1 1 Transglutaminase-like superfamily Gln_amidase PF15644.6 CCF38177.1 - 0.096 13.7 0.0 0.28 12.2 0.0 1.9 1 1 0 1 1 1 0 Papain fold toxin 1, glutamine deamidase NTP_transferase PF00483.23 CCF38178.1 - 6.2e-06 26.0 0.0 8.9e-06 25.5 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 CCF38178.1 - 0.002 18.5 0.0 0.0032 17.8 0.0 1.4 1 0 0 1 1 1 1 MobA-like NTP transferase domain Rootletin PF15035.6 CCF38179.1 - 0.01 15.8 1.4 0.012 15.6 1.4 1.1 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion CENP-F_leu_zip PF10473.9 CCF38179.1 - 0.017 15.2 1.9 0.021 14.8 1.9 1.2 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 KASH_CCD PF14662.6 CCF38179.1 - 0.021 14.7 1.7 0.023 14.5 1.7 1.0 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH Rx_N PF18052.1 CCF38179.1 - 0.037 14.3 1.2 0.055 13.8 1.2 1.5 1 1 0 1 1 1 0 Rx N-terminal domain BIR PF00653.21 CCF38180.1 - 1.3e-12 48.1 0.1 2e-12 47.6 0.1 1.3 1 0 0 1 1 1 1 Inhibitor of Apoptosis domain Peptidase_S8 PF00082.22 CCF38181.1 - 5.8e-28 98.0 4.7 8.5e-28 97.5 4.7 1.2 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 CCF38181.1 - 1.8e-11 44.5 0.0 6.3e-11 42.8 0.0 1.9 2 0 0 2 2 2 1 Peptidase inhibitor I9 IMUP PF15761.5 CCF38181.1 - 5 7.9 8.4 64 4.3 0.0 3.4 3 0 0 3 3 3 0 Immortalisation up-regulated protein Zn_clus PF00172.18 CCF38182.1 - 1.2e-07 31.8 7.4 1.9e-07 31.1 7.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF3439 PF11921.8 CCF38182.1 - 0.0087 16.0 7.3 0.017 15.1 7.3 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3439) PSI_integrin PF17205.3 CCF38182.1 - 0.012 15.4 0.6 0.012 15.4 0.6 1.7 2 0 0 2 2 2 0 Integrin plexin domain GIT_CC PF16559.5 CCF38182.1 - 0.098 12.5 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor Dicty_REP PF05086.12 CCF38182.1 - 0.87 7.5 2.0 1.1 7.2 2.0 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Mucin PF01456.17 CCF38182.1 - 1.6 8.7 13.5 3.6 7.6 13.5 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein AA_permease PF00324.21 CCF38183.1 - 9.6e-140 466.3 34.9 1.1e-139 466.2 34.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CCF38183.1 - 1.8e-39 135.8 37.2 2.4e-39 135.4 37.2 1.0 1 0 0 1 1 1 1 Amino acid permease PDGLE PF13190.6 CCF38185.1 - 0.036 13.9 0.1 0.04 13.8 0.1 1.0 1 0 0 1 1 1 0 PDGLE domain Methyltransf_23 PF13489.6 CCF38186.1 - 1.6e-17 63.8 0.0 6.2e-17 61.9 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF38186.1 - 5e-12 45.9 0.0 2.6e-11 43.5 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF38186.1 - 5.2e-09 36.7 0.0 1.3e-08 35.4 0.0 1.7 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF38186.1 - 1.2e-06 29.0 0.0 3.6e-06 27.5 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF38186.1 - 2e-06 28.4 0.0 8.1e-06 26.5 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CCF38186.1 - 0.0027 17.3 0.0 0.0075 15.8 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_16 PF10294.9 CCF38186.1 - 0.0028 17.4 0.0 0.0044 16.8 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase PrmA PF06325.13 CCF38186.1 - 0.046 13.1 0.0 0.068 12.6 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_2 PF00891.18 CCF38186.1 - 0.055 12.8 0.0 0.12 11.6 0.0 1.5 2 0 0 2 2 2 0 O-methyltransferase domain Methyltransf_4 PF02390.17 CCF38186.1 - 0.057 12.9 0.0 0.11 11.9 0.0 1.5 1 0 0 1 1 1 0 Putative methyltransferase CMAS PF02353.20 CCF38186.1 - 0.085 12.1 0.0 0.14 11.4 0.0 1.4 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase Cu-oxidase_2 PF07731.14 CCF38187.1 - 1.3e-23 83.3 0.6 1.8e-23 82.8 0.6 1.2 1 0 0 1 1 1 1 Multicopper oxidase Fungal_trans PF04082.18 CCF38188.1 - 8.9e-12 44.6 0.0 1.5e-11 43.9 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF38188.1 - 0.0033 17.5 5.2 0.0056 16.8 5.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pyr_redox_2 PF07992.14 CCF38190.1 - 2.8e-40 138.4 0.0 3.3e-40 138.2 0.0 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCF38190.1 - 6.5e-11 42.4 3.0 0.0077 15.8 0.0 4.1 4 0 0 4 4 4 4 FAD dependent oxidoreductase Pyr_redox PF00070.27 CCF38190.1 - 7.7e-11 42.4 0.3 3.2e-08 34.0 0.0 2.7 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CCF38190.1 - 1.1e-06 28.7 0.4 0.18 11.8 0.0 3.4 2 1 1 3 3 3 3 FAD-NAD(P)-binding Pyr_redox_3 PF13738.6 CCF38190.1 - 0.0052 16.1 0.0 3.2 6.9 0.0 3.4 4 0 0 4 4 4 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 CCF38190.1 - 0.041 12.7 1.3 17 4.1 0.0 3.0 2 1 1 3 3 3 0 Tryptophan halogenase NAD_binding_8 PF13450.6 CCF38190.1 - 0.13 12.5 0.1 17 5.7 0.0 2.8 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Fungal_trans PF04082.18 CCF38191.1 - 5.8e-09 35.4 0.0 2e-08 33.6 0.1 1.9 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF38191.1 - 0.0017 18.4 4.6 0.004 17.3 4.6 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RcsF PF16358.5 CCF38191.1 - 0.081 13.0 0.0 0.23 11.5 0.0 1.8 1 0 0 1 1 1 0 RcsF lipoprotein Gpr1_Fun34_YaaH PF01184.19 CCF38192.1 - 4.3e-31 108.1 24.9 5.3e-31 107.8 24.9 1.1 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family DUF3827 PF12877.7 CCF38192.1 - 0.59 8.4 1.5 0.78 8.0 1.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) Adeno_E3B PF03376.14 CCF38192.1 - 2.3 8.5 5.6 5.3 7.4 5.6 1.6 1 0 0 1 1 1 0 Adenovirus E3B protein BTB PF00651.31 CCF38193.1 - 8.6e-09 35.6 0.0 8.1e-07 29.3 0.0 2.3 2 0 0 2 2 2 2 BTB/POZ domain Bac_DnaA PF00308.18 CCF38193.1 - 0.17 11.7 0.0 0.26 11.1 0.0 1.2 1 0 0 1 1 1 0 Bacterial dnaA protein Cutinase PF01083.22 CCF38194.1 - 2.1e-31 109.2 0.2 3.6e-31 108.5 0.2 1.3 1 1 0 1 1 1 1 Cutinase PE-PPE PF08237.11 CCF38194.1 - 0.013 15.1 0.0 0.021 14.4 0.0 1.3 1 0 0 1 1 1 0 PE-PPE domain VirJ PF06057.11 CCF38194.1 - 0.098 12.5 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 Bacterial virulence protein (VirJ) BIR PF00653.21 CCF38196.1 - 3.4e-46 155.8 2.6 4.6e-22 78.4 0.0 2.6 2 0 0 2 2 2 2 Inhibitor of Apoptosis domain HRXXH PF13933.6 CCF38197.1 - 2e-106 355.1 0.1 2.4e-106 354.8 0.1 1.1 1 0 0 1 1 1 1 Putative peptidase family Aspzincin_M35 PF14521.6 CCF38197.1 - 5.4e-06 27.0 0.0 1.2e-05 25.9 0.0 1.6 1 0 0 1 1 1 1 Lysine-specific metallo-endopeptidase MFS_1 PF07690.16 CCF38198.1 - 1.4e-38 132.7 46.5 6.6e-38 130.5 46.3 2.5 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF38198.1 - 6.9e-13 48.2 8.3 6.9e-13 48.2 8.3 2.8 3 0 0 3 3 3 2 Sugar (and other) transporter TRI12 PF06609.13 CCF38198.1 - 0.00082 17.9 21.4 0.0019 16.7 21.4 1.5 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Steroid_dh PF02544.16 CCF38199.1 - 2.6e-14 53.5 0.7 2.9e-14 53.3 0.7 1.1 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.12 CCF38199.1 - 0.023 14.2 2.4 0.03 13.8 2.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1295) DUF639 PF04842.12 CCF38199.1 - 0.11 11.9 0.1 0.14 11.5 0.1 1.2 1 0 0 1 1 1 0 Plant protein of unknown function (DUF639) MFS_1 PF07690.16 CCF38200.1 - 3.5e-26 92.0 25.7 1.1e-25 90.3 25.0 1.8 2 0 0 2 2 2 1 Major Facilitator Superfamily LapA_dom PF06305.11 CCF38200.1 - 1.8 8.4 4.4 74 3.3 0.1 3.8 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain p450 PF00067.22 CCF38201.1 - 3.6e-51 174.4 0.0 4.8e-51 173.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Cu-oxidase_2 PF07731.14 CCF38202.1 - 1.2e-19 70.4 0.7 3e-19 69.1 0.7 1.7 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase PF00394.22 CCF38202.1 - 6.1e-15 55.7 0.1 1.1e-14 54.9 0.1 1.4 1 0 0 1 1 1 1 Multicopper oxidase Glyco_transf_5 PF08323.11 CCF38203.1 - 5.5e-15 55.7 0.3 1.2e-14 54.7 0.1 1.6 2 0 0 2 2 2 1 Starch synthase catalytic domain Alpha-amylase PF00128.24 CCF38203.1 - 4e-14 52.9 7.0 4.1e-14 52.9 1.5 3.0 2 1 0 2 2 2 1 Alpha amylase, catalytic domain p450 PF00067.22 CCF38205.1 - 1.5e-58 198.7 0.0 2.6e-58 197.9 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 CFEM PF05730.11 CCF38206.1 - 5e-12 45.7 10.6 7.8e-12 45.1 10.6 1.3 1 0 0 1 1 1 1 CFEM domain Annexin PF00191.20 CCF38207.1 - 1.3e-16 60.4 0.3 0.00024 21.1 0.0 4.3 4 0 0 4 4 4 3 Annexin DUF5617 PF18493.1 CCF38207.1 - 0.033 14.3 0.2 0.077 13.1 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5617) adh_short PF00106.25 CCF38210.1 - 1.9e-38 131.9 0.0 4.2e-38 130.8 0.0 1.5 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF38210.1 - 7.5e-28 97.7 0.0 1.3e-27 96.9 0.0 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF38210.1 - 4.3e-13 49.6 0.0 6.5e-13 49.0 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF38210.1 - 3.5e-07 30.0 0.0 5.2e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CCF38210.1 - 8.6e-07 28.7 0.2 9.8e-06 25.2 0.2 2.0 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 CCF38210.1 - 2.9e-06 27.3 0.0 6.5e-06 26.2 0.0 1.6 1 1 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 CCF38210.1 - 1.9e-05 24.9 0.0 4.7e-05 23.7 0.0 1.6 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain F420_oxidored PF03807.17 CCF38210.1 - 0.0024 18.4 0.0 0.013 16.0 0.0 2.1 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent NmrA PF05368.13 CCF38210.1 - 0.0059 16.2 0.0 0.0087 15.6 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family Enoyl_reductase PF12241.8 CCF38210.1 - 0.017 14.5 0.0 0.027 13.8 0.0 1.3 1 0 0 1 1 1 0 Trans-2-enoyl-CoA reductase catalytic region Polysacc_synt_2 PF02719.15 CCF38210.1 - 0.026 13.7 0.0 0.075 12.1 0.0 1.7 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein GST_C_2 PF13410.6 CCF38212.1 - 1.5e-09 37.7 0.1 4e-09 36.4 0.1 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 CCF38212.1 - 3.8e-07 30.3 0.0 6.2e-07 29.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 CCF38212.1 - 1.5e-06 28.5 0.0 4.4e-06 27.0 0.0 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_5 PF16865.5 CCF38212.1 - 0.0016 19.0 0.0 0.0024 18.4 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 CCF38212.1 - 0.002 18.3 0.1 0.0054 16.9 0.1 1.8 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 CCF38212.1 - 0.0091 16.2 0.1 0.016 15.4 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 CCF38212.1 - 0.011 15.6 0.1 0.02 14.7 0.1 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain SCAN PF02023.17 CCF38212.1 - 0.12 12.2 0.1 0.25 11.2 0.1 1.5 1 0 0 1 1 1 0 SCAN domain RTA1 PF04479.13 CCF38213.1 - 4.6e-52 176.6 6.1 5.9e-52 176.3 6.1 1.1 1 0 0 1 1 1 1 RTA1 like protein Lipase_GDSL_2 PF13472.6 CCF38214.1 - 7.4e-16 59.1 0.0 9.9e-16 58.6 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 CCF38214.1 - 8.7e-07 29.1 0.0 2.2e-06 27.8 0.0 1.7 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Sugar_tr PF00083.24 CCF38215.1 - 1.2e-111 373.8 23.9 3.2e-111 372.4 23.9 1.6 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF38215.1 - 1.2e-23 83.6 36.2 1.1e-17 64.0 15.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily ECH_1 PF00378.20 CCF38216.1 - 2.6e-21 76.1 0.0 7.4e-16 58.2 0.0 3.1 3 0 0 3 3 3 3 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CCF38216.1 - 2.1e-11 43.9 0.2 1.2e-08 34.8 0.0 2.6 3 0 0 3 3 3 2 Enoyl-CoA hydratase/isomerase Pkinase PF00069.25 CCF38218.1 - 2e-57 194.6 0.0 2.6e-57 194.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF38218.1 - 1.8e-21 76.6 0.0 3e-21 75.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF38218.1 - 4.1e-06 26.3 0.0 6.8e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 CCF38218.1 - 0.00021 21.3 0.4 0.013 15.5 0.2 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 CCF38218.1 - 0.00032 20.1 0.1 0.00052 19.4 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 CCF38218.1 - 0.00035 19.6 0.2 0.00063 18.8 0.2 1.3 1 1 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 CCF38218.1 - 0.016 14.8 0.0 0.043 13.4 0.0 1.7 1 0 0 1 1 1 0 RIO1 family Pkinase_fungal PF17667.1 CCF38218.1 - 0.02 13.7 0.1 0.052 12.3 0.0 1.6 2 0 0 2 2 2 0 Fungal protein kinase FMO-like PF00743.19 CCF38219.1 - 5.7e-11 41.5 0.0 7.4e-11 41.2 0.0 1.1 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like K_oxygenase PF13434.6 CCF38219.1 - 9.2e-10 38.2 0.0 3.1e-08 33.2 0.1 2.0 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 CCF38219.1 - 7.5e-09 35.3 0.0 1.4e-08 34.4 0.0 1.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CCF38219.1 - 2e-06 27.2 0.0 3.4e-06 26.5 0.0 1.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCF38219.1 - 4.2e-06 26.9 0.1 5.3e-05 23.4 0.0 2.6 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CCF38219.1 - 0.015 14.9 0.3 3.8 7.0 0.1 2.2 1 1 0 2 2 2 0 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 CCF38219.1 - 0.037 14.0 0.1 0.46 10.5 0.1 2.4 1 1 0 1 1 1 0 FAD-NAD(P)-binding Thi4 PF01946.17 CCF38219.1 - 0.045 13.0 0.1 0.091 12.0 0.1 1.4 1 0 0 1 1 1 0 Thi4 family Chor_lyase PF04345.13 CCF38219.1 - 0.14 11.8 0.0 0.22 11.2 0.0 1.2 1 0 0 1 1 1 0 Chorismate lyase ThiF PF00899.21 CCF38221.1 - 9.7e-30 103.7 0.0 1.3e-29 103.3 0.0 1.1 1 0 0 1 1 1 1 ThiF family Oxidored_FMN PF00724.20 CCF38223.1 - 9.9e-67 225.6 0.0 2.9e-63 214.2 0.0 2.1 1 1 1 2 2 2 2 NADH:flavin oxidoreductase / NADH oxidase family Dus PF01207.17 CCF38223.1 - 0.015 14.4 0.1 0.13 11.3 0.1 2.0 2 0 0 2 2 2 0 Dihydrouridine synthase (Dus) Meth_synt_2 PF01717.18 CCF38224.1 - 3.2e-143 476.9 0.0 3.6e-143 476.7 0.0 1.0 1 0 0 1 1 1 1 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.12 CCF38224.1 - 6.8e-06 25.8 0.0 5.9e-05 22.7 0.0 2.1 2 1 0 2 2 2 1 Cobalamin-independent synthase, N-terminal domain URO-D PF01208.17 CCF38224.1 - 0.0054 15.9 0.0 0.014 14.6 0.0 1.6 2 0 0 2 2 2 1 Uroporphyrinogen decarboxylase (URO-D) DUF3018 PF11455.8 CCF38224.1 - 0.058 13.3 0.1 0.24 11.3 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3018) Zn_clus PF00172.18 CCF38226.1 - 0.0011 19.0 7.4 0.0017 18.5 7.4 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-U1 PF06220.12 CCF38227.1 - 4.5e-07 29.5 0.2 7e-07 28.9 0.2 1.3 1 0 0 1 1 1 1 U1 zinc finger PIR PF00399.19 CCF38228.1 - 0.022 14.3 7.4 0.68 9.6 3.6 3.4 2 0 0 2 2 2 0 Yeast PIR protein repeat FAD-oxidase_C PF02913.19 CCF38229.1 - 5.1e-06 26.3 0.0 5.3e-06 26.2 0.0 1.1 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain adh_short PF00106.25 CCF38230.1 - 7.3e-34 116.9 0.0 1.6e-33 115.8 0.0 1.5 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF38230.1 - 1.6e-22 80.2 0.0 2.6e-22 79.5 0.0 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF38230.1 - 5.2e-11 42.8 0.0 6.8e-11 42.4 0.0 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF38230.1 - 1.1e-06 28.3 0.0 1.4e-06 28.0 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CCF38230.1 - 1.7e-05 24.8 0.0 2.5e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 CCF38230.1 - 0.0052 16.0 0.0 0.0074 15.5 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 CCF38230.1 - 0.01 15.0 0.0 0.023 13.9 0.0 1.5 1 1 0 1 1 1 0 Male sterility protein Methyltransf_31 PF13847.6 CCF38230.1 - 0.045 13.6 0.0 0.064 13.0 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain EPL1 PF10513.9 CCF38231.1 - 1.6e-21 77.4 3.5 1.6e-21 77.4 3.5 3.6 3 1 0 3 3 3 1 Enhancer of polycomb-like Spt20 PF12090.8 CCF38231.1 - 8.7 5.9 15.7 23 4.5 15.3 1.9 2 0 0 2 2 2 0 Spt20 family DUF1180 PF06679.12 CCF38232.1 - 0.011 16.2 0.2 0.011 16.1 0.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) ASL_C2 PF14698.6 CCF38233.1 - 1e-18 67.8 0.1 2.6e-18 66.5 0.0 1.7 2 0 0 2 2 2 1 Argininosuccinate lyase C-terminal Lyase_1 PF00206.20 CCF38233.1 - 7.6e-15 55.1 0.0 1e-14 54.6 0.0 1.2 1 0 0 1 1 1 1 Lyase Rtt106 PF08512.12 CCF38234.1 - 3.8e-30 104.2 0.0 1.3e-29 102.5 0.0 1.8 2 0 0 2 2 2 1 Histone chaperone Rttp106-like PH_18 PF18469.1 CCF38234.1 - 4.7e-05 23.4 0.0 0.00017 21.6 0.0 1.9 2 1 0 2 2 2 1 Pleckstrin homology domain Cwf_Cwc_15 PF04889.12 CCF38234.1 - 1 9.0 26.6 1.5 8.5 26.6 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Rad52_Rad22 PF04098.15 CCF38236.1 - 9.1e-62 207.5 0.0 1.3e-61 207.0 0.0 1.2 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein DnaJ PF00226.31 CCF38237.1 - 5.9e-15 55.1 2.4 7.9e-15 54.7 2.4 1.2 1 0 0 1 1 1 1 DnaJ domain FA_desaturase PF00487.24 CCF38238.1 - 1.3e-18 67.7 15.2 1.3e-18 67.7 15.2 1.9 1 1 1 2 2 2 1 Fatty acid desaturase Cyt-b5 PF00173.28 CCF38238.1 - 0.0035 17.5 0.0 0.0078 16.3 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain FA_hydroxylase PF04116.13 CCF38238.1 - 0.15 12.4 14.2 0.51 10.7 6.5 2.7 2 1 0 2 2 2 0 Fatty acid hydroxylase superfamily COesterase PF00135.28 CCF38239.1 - 1.6e-71 241.7 0.0 3.1e-64 217.7 0.0 2.0 2 0 0 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.13 CCF38239.1 - 3.8e-06 26.9 0.0 1.7e-05 24.8 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_M13_N PF05649.13 CCF38240.1 - 6.8e-61 207.0 0.0 8.8e-61 206.7 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13 PF01431.21 CCF38240.1 - 1.3e-57 194.7 0.1 2e-57 194.1 0.1 1.3 1 0 0 1 1 1 1 Peptidase family M13 Peroxidase_2 PF01328.17 CCF38241.1 - 2e-51 175.2 0.0 2.5e-51 174.9 0.0 1.0 1 0 0 1 1 1 1 Peroxidase, family 2 FA_hydroxylase PF04116.13 CCF38242.1 - 2e-22 80.0 8.7 2e-22 80.0 8.7 2.3 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Nuc_H_symport PF03825.16 CCF38243.1 - 0.0047 16.0 0.1 0.0055 15.7 0.1 1.0 1 0 0 1 1 1 1 Nucleoside H+ symporter MFS_1_like PF12832.7 CCF38243.1 - 0.034 13.0 0.3 0.036 12.9 0.3 1.0 1 0 0 1 1 1 0 MFS_1 like family E1-E2_ATPase PF00122.20 CCF38244.1 - 0.068 12.7 0.6 0.12 11.9 0.6 1.3 1 0 0 1 1 1 0 E1-E2 ATPase RasGEF_N_2 PF14663.6 CCF38244.1 - 0.081 13.3 0.1 0.15 12.5 0.1 1.5 1 1 0 1 1 1 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain DUF3176 PF11374.8 CCF38244.1 - 0.12 12.6 4.6 0.11 12.7 3.5 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3176) LANC_like PF05147.13 CCF38245.1 - 6.9e-19 67.6 0.0 2.9e-18 65.6 0.0 1.8 1 1 0 1 1 1 1 Lanthionine synthetase C-like protein Chitin_bind_1 PF00187.19 CCF38246.1 - 9.4e-19 67.6 43.6 6e-10 39.4 20.5 2.4 2 0 0 2 2 2 2 Chitin recognition protein 4HBT_3 PF13622.6 CCF38247.1 - 2.2e-50 172.2 0.0 2.6e-50 172.0 0.0 1.0 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.15 CCF38247.1 - 0.015 15.2 0.0 0.024 14.5 0.0 1.3 1 0 0 1 1 1 0 Acyl-CoA thioesterase NPHI_C PF08469.10 CCF38247.1 - 0.038 13.9 0.0 0.21 11.5 0.0 1.9 2 0 0 2 2 2 0 Nucleoside triphosphatase I C-terminal Aa_trans PF01490.18 CCF38248.1 - 1.4e-43 149.1 31.4 1.6e-43 149.0 31.4 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein LEAP-2 PF07359.11 CCF38249.1 - 0.63 9.9 7.5 1.5 8.7 0.6 2.4 1 1 1 2 2 2 0 Liver-expressed antimicrobial peptide 2 precursor (LEAP-2) MFS_1 PF07690.16 CCF38250.1 - 1.4e-49 168.9 19.2 2.9e-49 167.9 19.2 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF38250.1 - 3.5e-08 32.8 11.3 3.5e-08 32.8 11.3 2.3 3 0 0 3 3 3 1 Sugar (and other) transporter MFS_3 PF05977.13 CCF38250.1 - 0.0004 18.9 4.4 0.0004 18.9 4.4 2.1 3 0 0 3 3 3 1 Transmembrane secretion effector TRI12 PF06609.13 CCF38250.1 - 0.0004 18.9 4.7 0.00065 18.3 4.7 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.20 CCF38250.1 - 0.096 11.0 3.5 0.12 10.6 2.8 1.4 1 1 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Tom5 PF10642.9 CCF38250.1 - 0.72 9.9 2.6 3 7.9 2.6 2.1 1 0 0 1 1 1 0 Mitochondrial import receptor subunit or translocase Syntaxin-18_N PF10496.9 CCF38251.1 - 3.8e-12 46.3 0.2 1.1e-11 44.8 0.1 1.9 2 1 0 2 2 2 1 SNARE-complex protein Syntaxin-18 N-terminus Phage_int_SAM_2 PF12834.7 CCF38251.1 - 0.0056 17.3 0.7 0.28 11.9 0.1 2.0 1 1 0 2 2 2 1 Phage integrase, N-terminal Rx_N PF18052.1 CCF38251.1 - 0.075 13.3 0.6 6.8 7.0 0.0 2.2 2 0 0 2 2 2 0 Rx N-terminal domain CH PF00307.31 CCF38252.1 - 5.2e-07 29.8 0.7 6.5e-07 29.5 0.7 1.1 1 0 0 1 1 1 1 Calponin homology (CH) domain CH_2 PF06294.11 CCF38252.1 - 0.012 15.7 0.2 0.017 15.2 0.2 1.3 1 1 0 1 1 1 0 CH-like domain in sperm protein DEAD PF00270.29 CCF38253.1 - 1.6e-46 158.3 0.1 3.1e-46 157.4 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF38253.1 - 8.4e-30 103.4 0.4 6e-29 100.6 0.2 2.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain UTP25 PF06862.12 CCF38253.1 - 0.00019 20.4 0.8 0.00089 18.2 0.1 2.3 1 1 2 3 3 3 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 DUF2802 PF10975.8 CCF38253.1 - 0.2 11.8 2.7 5.2 7.3 1.6 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2802) WSK PF03832.13 CCF38253.1 - 1.7 8.4 12.5 1.9 8.2 4.9 2.8 2 0 0 2 2 2 0 WSK motif Cys_Met_Meta_PP PF01053.20 CCF38254.1 - 7e-10 38.0 0.0 3.7e-09 35.6 0.0 1.8 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Terpene_synth_C PF03936.16 CCF38255.1 - 1.4e-07 31.1 0.1 6.7e-07 28.9 0.1 1.9 1 1 0 1 1 1 1 Terpene synthase family, metal binding domain ANTAR PF03861.14 CCF38255.1 - 0.18 11.7 0.0 0.43 10.5 0.0 1.6 1 0 0 1 1 1 0 ANTAR domain zf-U1 PF06220.12 CCF38255.1 - 0.2 11.5 1.8 5 7.0 0.4 2.7 3 0 0 3 3 3 0 U1 zinc finger Polysacc_deac_1 PF01522.21 CCF38256.1 - 0.00029 20.7 0.0 0.0005 20.0 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase Polysacc_deac_2 PF04748.13 CCF38256.1 - 0.0037 16.5 0.0 0.0057 15.9 0.0 1.4 1 1 0 1 1 1 1 Divergent polysaccharide deacetylase DNA_pol_B_thumb PF14791.6 CCF38256.1 - 0.098 12.8 0.1 0.3 11.3 0.0 1.8 2 0 0 2 2 2 0 DNA polymerase beta thumb MRP-L28 PF09812.9 CCF38257.1 - 0.00086 19.5 0.2 0.0013 18.9 0.2 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L28 Herpes_UL49_2 PF04823.12 CCF38257.1 - 0.085 13.0 2.9 0.15 12.2 0.1 2.2 2 1 0 2 2 2 0 Herpesvirus UL49 tegument protein DUF4202 PF13875.6 CCF38260.1 - 3.6e-08 33.5 0.0 3.9e-08 33.4 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4202) TrmO_C PF18389.1 CCF38260.1 - 0.047 13.8 0.5 0.056 13.6 0.5 1.2 1 1 0 1 1 1 0 TrmO C-terminal domain Sigma70_r4_2 PF08281.12 CCF38260.1 - 0.085 12.6 0.0 0.21 11.3 0.0 1.6 2 0 0 2 2 2 0 Sigma-70, region 4 Myb_DNA-bind_6 PF13921.6 CCF38261.1 - 0.00015 21.9 0.1 0.0032 17.7 0.0 2.5 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 CCF38261.1 - 0.00019 21.6 0.1 0.00037 20.6 0.1 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Dicty_REP PF05086.12 CCF38263.1 - 8.3 4.2 6.4 10 3.9 6.4 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Glyco_hydro_35 PF01301.19 CCF38264.1 - 1.5e-62 212.0 0.1 1.7e-62 211.8 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 Cellulase PF00150.18 CCF38264.1 - 3.4e-06 26.7 0.0 5e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_42 PF02449.15 CCF38264.1 - 3.9e-06 26.5 0.2 1.5e-05 24.5 0.2 1.8 1 1 0 1 1 1 1 Beta-galactosidase WRNPLPNID PF15017.6 CCF38264.1 - 0.18 12.7 0.0 0.37 11.7 0.0 1.4 1 0 0 1 1 1 0 Putative WW-binding domain and destruction box SH2_2 PF14633.6 CCF38265.1 - 6.2e-84 280.7 0.0 1.3e-83 279.7 0.0 1.6 1 0 0 1 1 1 1 SH2 domain HTH_44 PF14641.6 CCF38265.1 - 2.2e-39 134.4 1.0 6.5e-39 132.9 1.0 1.8 1 0 0 1 1 1 1 Helix-turn-helix DNA-binding domain of SPT6 HHH_7 PF14635.6 CCF38265.1 - 7e-31 106.7 0.0 1.5e-30 105.6 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif YqgF PF14639.6 CCF38265.1 - 1.9e-29 102.4 0.0 1.8e-28 99.3 0.0 2.5 2 0 0 2 2 2 1 Holliday-junction resolvase-like of SPT6 SPT6_acidic PF14632.6 CCF38265.1 - 4.4e-07 30.4 4.9 4.4e-07 30.4 4.9 6.9 4 2 3 7 7 7 1 Acidic N-terminal SPT6 HHH_9 PF17674.1 CCF38265.1 - 5.3e-06 27.2 5.8 2.1e-05 25.4 2.0 3.8 3 1 0 3 3 3 1 HHH domain SH2 PF00017.24 CCF38265.1 - 0.00018 21.5 0.0 0.00049 20.1 0.0 1.8 1 0 0 1 1 1 1 SH2 domain HHH_3 PF12836.7 CCF38265.1 - 0.00022 21.4 0.0 0.00064 19.9 0.0 1.9 1 0 0 1 1 1 1 Helix-hairpin-helix motif PSD4 PF07631.11 CCF38265.1 - 0.17 12.4 4.2 2.6 8.6 0.0 3.5 3 1 0 3 3 3 0 Protein of unknown function (DUF1592) Exo_endo_phos PF03372.23 CCF38266.1 - 1.6e-09 37.6 0.0 2.9e-09 36.8 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-GRF PF06839.12 CCF38266.1 - 0.00061 19.8 5.0 0.0017 18.4 5.0 1.8 1 1 0 1 1 1 1 GRF zinc finger Exo_endo_phos_2 PF14529.6 CCF38266.1 - 0.0038 17.1 0.0 1.7 8.5 0.0 2.4 1 1 1 2 2 2 2 Endonuclease-reverse transcriptase HMG_box PF00505.19 CCF38267.1 - 7.1e-22 77.6 1.1 1.1e-21 77.0 1.1 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 CCF38267.1 - 9.6e-08 32.5 0.3 1.6e-07 31.8 0.3 1.3 1 0 0 1 1 1 1 HMG-box domain MATalpha_HMGbox PF04769.12 CCF38267.1 - 0.0073 15.6 0.0 0.011 15.0 0.0 1.3 1 0 0 1 1 1 1 Mating-type protein MAT alpha 1 HMG-box BCL9 PF11502.8 CCF38268.1 - 0.73 9.7 4.2 1.9 8.4 4.2 1.7 1 0 0 1 1 1 0 B-cell lymphoma 9 protein APG6_N PF17675.1 CCF38268.1 - 8.5 6.9 10.0 4.3 7.9 3.9 3.3 3 1 0 3 3 3 0 Apg6 coiled-coil region WD40 PF00400.32 CCF38269.1 - 2.4e-11 44.0 6.3 0.00041 21.1 0.0 5.3 4 0 0 4 4 4 3 WD domain, G-beta repeat ADH_zinc_N PF00107.26 CCF38270.1 - 1.2e-25 90.0 0.1 1.9e-25 89.3 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCF38270.1 - 5.5e-07 30.7 0.0 0.0004 21.4 0.0 2.3 1 1 1 2 2 2 2 Zinc-binding dehydrogenase ADH_N PF08240.12 CCF38270.1 - 1.6e-06 27.9 0.0 6.5e-06 26.0 0.0 1.9 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain adh_short PF00106.25 CCF38270.1 - 0.15 11.5 0.6 0.23 10.9 0.6 1.3 1 0 0 1 1 1 0 short chain dehydrogenase Spt5-NGN PF03439.13 CCF38271.1 - 4.3e-25 87.4 0.1 7.6e-25 86.6 0.1 1.4 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section Spt5_N PF11942.8 CCF38271.1 - 6.8e-22 78.3 10.0 6.8e-22 78.3 10.0 3.6 3 0 0 3 3 3 1 Spt5 transcription elongation factor, acidic N-terminal KOW PF00467.29 CCF38271.1 - 7.3e-05 22.6 0.6 7.3e-05 22.6 0.6 4.4 4 0 0 4 4 4 1 KOW motif Glyco_trans_2_3 PF13632.6 CCF38272.1 - 7.9e-51 172.8 2.9 7.9e-51 172.8 2.9 1.7 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 CCF38272.1 - 4.7e-07 29.8 0.0 8e-07 29.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 CCF38272.1 - 0.00045 19.7 0.0 0.001 18.6 0.0 1.5 1 1 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_3 PF13641.6 CCF38272.1 - 0.0072 16.2 0.0 0.012 15.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 CLTH PF10607.9 CCF38273.1 - 3.5e-37 127.5 0.0 6.1e-37 126.8 0.0 1.4 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 CCF38273.1 - 0.001 18.9 0.1 0.0027 17.6 0.1 1.8 1 0 0 1 1 1 1 LisH DUF2795 PF11387.8 CCF38273.1 - 0.02 15.1 0.0 1.4 9.2 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2795) Transket_pyr PF02779.24 CCF38274.1 - 2.1e-42 144.8 0.0 3.2e-42 144.2 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 CCF38274.1 - 9.9e-33 112.7 0.1 2.8e-32 111.2 0.0 1.8 2 0 0 2 2 2 1 Transketolase, C-terminal domain PFOR_II PF17147.4 CCF38274.1 - 5.1e-05 23.5 0.0 0.003 17.8 0.0 2.4 2 0 0 2 2 2 1 Pyruvate:ferredoxin oxidoreductase core domain II F-actin_cap_A PF01267.17 CCF38275.1 - 9.6e-100 333.4 0.0 1.1e-99 333.2 0.0 1.0 1 0 0 1 1 1 1 F-actin capping protein alpha subunit DUF3822 PF12864.7 CCF38275.1 - 0.017 14.3 0.1 0.031 13.5 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3822) ACAS_N PF16177.5 CCF38275.1 - 0.02 14.8 0.0 0.049 13.6 0.0 1.6 1 0 0 1 1 1 0 Acetyl-coenzyme A synthetase N-terminus CSTF2_hinge PF14327.6 CCF38275.1 - 0.14 12.6 0.0 0.35 11.4 0.0 1.6 2 0 0 2 2 2 0 Hinge domain of cleavage stimulation factor subunit 2 Amidohydro_1 PF01979.20 CCF38276.1 - 1.2e-44 153.1 0.2 1.4e-44 152.8 0.2 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 CCF38276.1 - 5.4e-21 75.6 0.1 1.7e-14 54.2 0.1 2.2 2 0 0 2 2 2 2 Amidohydrolase family FtsL PF04999.13 CCF38276.1 - 0.11 12.5 0.0 0.22 11.6 0.0 1.4 1 0 0 1 1 1 0 Cell division protein FtsL DUF1640 PF07798.11 CCF38278.1 - 1.5e-57 194.4 9.5 1.8e-57 194.2 9.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) GNAT_acetyltr_2 PF13718.6 CCF38278.1 - 0.025 14.0 0.8 0.068 12.6 0.0 1.8 1 1 1 2 2 2 0 GNAT acetyltransferase 2 Lzipper-MIP1 PF14389.6 CCF38278.1 - 0.094 13.0 2.9 12 6.3 0.0 2.6 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 Metal_resist PF13801.6 CCF38278.1 - 0.35 11.1 4.3 0.15 12.3 1.2 2.0 2 0 0 2 2 2 0 Heavy-metal resistance cwf21 PF08312.12 CCF38278.1 - 0.95 9.7 6.2 0.52 10.5 3.6 1.9 2 1 0 2 2 2 0 cwf21 domain DUF1690 PF07956.11 CCF38278.1 - 1.2 9.5 13.5 0.91 9.9 6.4 2.2 1 1 1 2 2 2 0 Protein of Unknown function (DUF1690) BST2 PF16716.5 CCF38278.1 - 6.9 7.3 12.7 0.78 10.4 1.8 2.3 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 Pkinase PF00069.25 CCF38280.1 - 1.9e-63 214.3 0.0 1.2e-62 211.7 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF38280.1 - 5.2e-28 98.0 0.0 2.5e-27 95.8 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Haspin_kinase PF12330.8 CCF38280.1 - 0.015 14.3 0.0 0.039 12.9 0.0 1.6 1 1 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 CCF38280.1 - 0.051 12.9 0.1 0.1 12.0 0.1 1.4 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CCF38280.1 - 0.062 13.2 0.0 0.19 11.6 0.0 1.8 1 0 0 1 1 1 0 Phosphotransferase enzyme family WD40 PF00400.32 CCF38281.1 - 2.7e-12 47.0 11.1 0.00044 21.0 0.5 4.9 4 1 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF38281.1 - 1.7e-08 34.6 0.0 0.00034 20.9 0.0 3.3 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CCF38281.1 - 0.00042 20.3 0.1 0.001 19.0 0.0 1.5 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 CCF38281.1 - 0.00045 20.1 0.1 1.9 8.6 0.0 3.1 3 0 0 3 3 3 2 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 CCF38281.1 - 0.0063 15.1 0.0 0.011 14.2 0.0 1.3 1 0 0 1 1 1 1 Cytochrome D1 heme domain Ras PF00071.22 CCF38283.1 - 3.4e-13 49.5 0.0 4.5e-13 49.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCF38283.1 - 1.4e-09 38.2 0.0 1.9e-09 37.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 CCF38283.1 - 2.7e-05 24.2 0.0 3.7e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CCF38283.1 - 0.012 15.2 0.0 1.8 8.1 0.0 2.1 1 1 0 2 2 2 0 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 CCF38283.1 - 0.022 14.7 0.1 0.63 9.9 0.1 2.2 1 1 0 2 2 2 0 RsgA GTPase Dynamin_N PF00350.23 CCF38283.1 - 0.024 14.7 0.5 0.24 11.4 0.1 2.0 1 1 0 2 2 2 0 Dynamin family AAA_24 PF13479.6 CCF38283.1 - 0.054 13.2 0.0 0.083 12.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 CCF38283.1 - 0.067 13.6 0.0 0.12 12.8 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_22 PF13401.6 CCF38283.1 - 0.075 13.3 0.0 0.12 12.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain Septin PF00735.18 CCF38283.1 - 0.096 11.9 0.0 0.13 11.5 0.0 1.2 1 0 0 1 1 1 0 Septin AAA_18 PF13238.6 CCF38283.1 - 0.18 12.3 0.1 0.51 10.9 0.0 1.8 3 0 0 3 3 3 0 AAA domain AIG1 PF04548.16 CCF38283.1 - 0.2 11.0 0.2 0.29 10.4 0.2 1.2 1 0 0 1 1 1 0 AIG1 family Ribosomal_S4e PF00900.20 CCF38284.1 - 5.9e-37 125.4 0.7 1.4e-36 124.2 0.2 1.9 2 0 0 2 2 2 1 Ribosomal family S4e 40S_S4_C PF16121.5 CCF38284.1 - 1.2e-23 82.4 0.1 2.3e-23 81.5 0.1 1.5 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus RS4NT PF08071.12 CCF38284.1 - 9.4e-18 64.0 4.9 1.9e-17 63.1 4.9 1.5 1 0 0 1 1 1 1 RS4NT (NUC023) domain S4 PF01479.25 CCF38284.1 - 6.4e-06 25.8 0.0 1.2e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 S4 domain KOW PF00467.29 CCF38284.1 - 1.4e-05 24.8 1.8 1.4e-05 24.8 1.8 2.9 3 0 0 3 3 3 1 KOW motif Myb_DNA-binding PF00249.31 CCF38285.1 - 9.2e-15 54.6 0.0 4.5e-07 29.9 0.0 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CCF38285.1 - 1.1e-09 38.4 0.0 0.00059 20.0 0.0 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain SLIDE PF09111.10 CCF38285.1 - 3.2e-05 23.9 0.1 0.11 12.5 0.0 2.5 2 0 0 2 2 2 2 SLIDE Nop16 PF09420.10 CCF38285.1 - 0.018 15.1 1.1 0.049 13.7 0.1 2.1 2 0 0 2 2 2 0 Ribosome biogenesis protein Nop16 CHDCT2 PF08074.11 CCF38285.1 - 0.038 14.2 0.0 0.19 11.9 0.0 2.1 2 0 0 2 2 2 0 CHDCT2 (NUC038) domain SANT_DAMP1_like PF16282.5 CCF38285.1 - 0.11 12.7 0.0 0.27 11.4 0.0 1.6 1 0 0 1 1 1 0 SANT/Myb-like domain of DAMP1 Septin PF00735.18 CCF38288.1 - 5.1e-33 114.6 0.0 4.3e-11 42.6 0.0 3.2 3 0 0 3 3 3 3 Septin AAA_23 PF13476.6 CCF38288.1 - 0.012 16.1 0.8 0.033 14.7 0.0 2.0 3 0 0 3 3 3 0 AAA domain AAA_16 PF13191.6 CCF38288.1 - 0.02 15.3 0.0 0.066 13.6 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain FtsK_SpoIIIE PF01580.18 CCF38288.1 - 0.073 12.4 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family Dynamin_N PF00350.23 CCF38288.1 - 0.081 13.0 0.0 1.7 8.6 0.0 2.7 3 0 0 3 3 3 0 Dynamin family AAA_18 PF13238.6 CCF38288.1 - 0.089 13.3 0.0 0.9 10.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain G-alpha PF00503.20 CCF38288.1 - 0.095 11.8 0.0 0.52 9.4 0.0 2.0 2 0 0 2 2 2 0 G-protein alpha subunit DUF1035 PF06281.12 CCF38289.1 - 0.14 12.2 0.1 0.23 11.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1035) GrpB PF04229.14 CCF38290.1 - 6.5e-50 169.5 0.0 7.7e-50 169.2 0.0 1.1 1 0 0 1 1 1 1 GrpB protein FAD_binding_3 PF01494.19 CCF38291.1 - 6.4e-25 88.1 0.0 8.7e-25 87.7 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 CCF38291.1 - 1.3e-07 32.0 0.3 0.00089 19.8 0.2 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CCF38291.1 - 3.7e-07 29.7 0.1 0.02 14.1 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCF38291.1 - 3.4e-05 23.6 0.2 0.15 11.6 0.1 2.2 1 1 1 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CCF38291.1 - 0.0021 18.3 0.1 0.005 17.0 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 CCF38291.1 - 0.033 12.9 0.1 2.6 6.7 0.0 2.1 2 0 0 2 2 2 0 HI0933-like protein AlaDh_PNT_C PF01262.21 CCF38291.1 - 0.14 11.4 0.0 0.23 10.8 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain RhgB_N PF09284.10 CCF38294.1 - 6.4e-108 360.0 4.6 1.1e-107 359.3 4.6 1.4 1 0 0 1 1 1 1 Rhamnogalacturonan lyase B, N-terminal CBM-like PF14683.6 CCF38294.1 - 8.3e-45 152.6 0.0 2.7e-44 151.0 0.0 1.9 2 0 0 2 2 2 1 Polysaccharide lyase family 4, domain III fn3_3 PF14686.6 CCF38294.1 - 2.5e-24 84.8 7.4 8.2e-24 83.2 7.4 2.0 1 0 0 1 1 1 1 Polysaccharide lyase family 4, domain II CarboxypepD_reg PF13620.6 CCF38294.1 - 0.00062 20.0 6.7 0.00062 20.0 6.7 3.3 3 1 0 3 3 3 1 Carboxypeptidase regulatory-like domain Acylphosphatase PF00708.18 CCF38294.1 - 0.0033 17.8 0.0 0.016 15.6 0.0 2.0 2 0 0 2 2 2 1 Acylphosphatase DUF2012 PF09430.10 CCF38294.1 - 0.035 14.2 0.0 0.081 13.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2012) Kelch_2 PF07646.15 CCF38294.1 - 0.042 13.9 0.0 18 5.5 0.0 2.8 2 0 0 2 2 2 0 Kelch motif CarbopepD_reg_2 PF13715.6 CCF38294.1 - 0.16 12.0 4.5 0.11 12.5 1.3 2.4 2 1 0 2 2 2 0 CarboxypepD_reg-like domain zf-C2H2_4 PF13894.6 CCF38295.1 - 0.0036 18.0 3.6 0.011 16.5 0.2 2.8 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2 PF00096.26 CCF38295.1 - 0.0067 16.8 3.4 0.012 16.1 0.7 2.5 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-met PF12874.7 CCF38295.1 - 0.079 13.4 0.0 0.2 12.1 0.0 1.7 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2_8 PF15909.5 CCF38295.1 - 0.11 12.8 2.4 0.26 11.6 2.4 1.6 1 0 0 1 1 1 0 C2H2-type zinc ribbon Sugar_tr PF00083.24 CCF38296.1 - 6.4e-94 315.4 24.1 7.3e-94 315.2 24.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF38296.1 - 9.4e-26 90.6 57.5 3.4e-22 78.9 31.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily NmrA PF05368.13 CCF38297.1 - 9.4e-32 110.4 0.6 2.8e-31 108.9 0.6 1.6 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CCF38297.1 - 5e-11 42.8 0.1 3.1e-10 40.2 0.1 2.2 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CCF38297.1 - 0.0016 17.9 0.1 0.015 14.8 0.0 2.0 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 CCF38297.1 - 0.002 18.4 0.1 0.0059 16.9 0.1 1.8 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Semialdhyde_dh PF01118.24 CCF38297.1 - 0.003 18.0 0.1 0.01 16.2 0.0 1.9 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 CCF38297.1 - 0.032 13.2 0.1 0.054 12.5 0.1 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Sugar_tr PF00083.24 CCF38298.1 - 7.2e-90 302.0 11.3 1.1e-89 301.4 11.3 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF38298.1 - 3.7e-30 105.1 30.4 5.2e-30 104.6 23.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 CCF38298.1 - 1.6e-06 26.8 3.3 1.6e-06 26.8 3.3 1.6 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Asp_Glu_race PF01177.22 CCF38299.1 - 0.00018 21.5 0.0 0.00029 20.8 0.0 1.3 1 0 0 1 1 1 1 Asp/Glu/Hydantoin racemase RasGEF PF00617.19 CCF38300.1 - 9.1e-51 172.6 0.0 1.9e-50 171.5 0.0 1.6 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 CCF38300.1 - 8.2e-16 58.1 0.0 2.7e-15 56.5 0.0 2.0 1 0 0 1 1 1 1 RasGEF N-terminal motif SH3_9 PF14604.6 CCF38300.1 - 3.2e-06 26.9 0.0 5.6e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 CCF38300.1 - 3.7e-05 23.3 0.0 7.2e-05 22.3 0.0 1.5 1 0 0 1 1 1 1 SH3 domain 4HBT_3 PF13622.6 CCF38301.1 - 2e-51 175.6 0.2 2.3e-51 175.4 0.2 1.0 1 0 0 1 1 1 1 Thioesterase-like superfamily DUF4871 PF16167.5 CCF38302.1 - 0.051 13.6 0.6 4.1 7.4 0.5 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4871) Herpes_DNAp_acc PF04929.12 CCF38304.1 - 7 5.5 8.5 8.3 5.3 2.9 2.0 1 1 1 2 2 2 0 Herpes DNA replication accessory factor WSC PF01822.19 CCF38305.1 - 4.4e-28 97.3 21.7 6e-15 55.2 13.4 2.1 2 0 0 2 2 2 2 WSC domain RNB PF00773.19 CCF38306.1 - 1.9e-57 195.1 0.0 2.2e-57 194.9 0.0 1.0 1 0 0 1 1 1 1 RNB domain INCENP_ARK-bind PF03941.15 CCF38307.1 - 1.1e-17 63.7 0.2 1.1e-17 63.7 0.2 3.2 4 0 0 4 4 4 1 Inner centromere protein, ARK binding region 2OG-FeII_Oxy PF03171.20 CCF38308.1 - 2.6e-13 50.3 0.0 4.5e-13 49.5 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 CCF38308.1 - 4.4e-09 37.1 0.0 8.2e-09 36.3 0.0 1.4 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal Hepcidin PF06446.12 CCF38309.1 - 0.011 16.1 1.7 0.015 15.7 1.7 1.2 1 0 0 1 1 1 0 Hepcidin Orbi_VP6 PF01516.16 CCF38311.1 - 0.88 9.0 5.7 1.2 8.6 5.7 1.1 1 0 0 1 1 1 0 Orbivirus helicase VP6 Pkinase PF00069.25 CCF38312.1 - 2.8e-74 249.8 0.0 3.8e-74 249.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF38312.1 - 2.1e-37 128.8 0.0 3.3e-37 128.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase AdenylateSensor PF16579.5 CCF38312.1 - 7.8e-19 68.3 0.8 2e-10 41.2 0.3 3.2 2 1 0 2 2 2 2 Adenylate sensor of SNF1-like protein kinase UBA_2 PF08587.11 CCF38312.1 - 1.6e-15 57.0 0.2 3.4e-15 55.9 0.2 1.6 1 0 0 1 1 1 1 Ubiquitin associated domain (UBA) Kinase-like PF14531.6 CCF38312.1 - 2.7e-05 23.6 0.0 4.5e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 CCF38312.1 - 0.0013 18.4 0.0 0.0023 17.5 0.0 1.4 1 0 0 1 1 1 1 RIO1 family Haspin_kinase PF12330.8 CCF38312.1 - 0.0028 16.7 0.1 0.0058 15.6 0.1 1.6 2 0 0 2 2 2 1 Haspin like kinase domain YukC PF10140.9 CCF38312.1 - 0.0092 14.9 0.1 0.015 14.2 0.1 1.2 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukC APH PF01636.23 CCF38312.1 - 0.074 13.0 0.7 0.35 10.7 0.3 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family 4HBT PF03061.22 CCF38316.1 - 0.014 15.7 0.1 0.019 15.3 0.1 1.2 1 0 0 1 1 1 0 Thioesterase superfamily adh_short_C2 PF13561.6 CCF38317.1 - 2.5e-57 194.1 0.0 3.4e-57 193.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF38317.1 - 1.6e-45 155.0 0.0 2.2e-45 154.5 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF38317.1 - 9.3e-12 45.2 0.0 1.3e-11 44.8 0.0 1.1 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 CCF38317.1 - 0.029 13.8 0.0 0.036 13.4 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) SnoaL_2 PF12680.7 CCF38318.1 - 0.0022 18.6 0.0 0.0038 17.8 0.0 1.4 1 0 0 1 1 1 1 SnoaL-like domain Ribosomal_L2_C PF03947.18 CCF38320.1 - 1.2e-41 141.9 4.8 1.9e-41 141.2 4.8 1.3 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 CCF38320.1 - 4.1e-15 55.5 0.1 9.6e-15 54.3 0.1 1.7 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain DNA_pol_B_palm PF14792.6 CCF38321.1 - 5.2e-36 123.3 0.0 1e-35 122.4 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase beta palm DNA_pol_B_thumb PF14791.6 CCF38321.1 - 5e-26 90.7 0.1 5.5e-24 84.1 0.1 2.5 2 0 0 2 2 2 1 DNA polymerase beta thumb DNA_pol_lambd_f PF10391.9 CCF38321.1 - 1.7e-19 69.4 0.0 5.8e-19 67.7 0.0 2.1 1 0 0 1 1 1 1 Fingers domain of DNA polymerase lambda HHH_8 PF14716.6 CCF38321.1 - 6.3e-17 61.7 0.1 1.5e-16 60.5 0.1 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix domain HHH_5 PF14520.6 CCF38321.1 - 0.013 16.1 0.7 6.2 7.5 0.0 3.2 3 0 0 3 3 3 0 Helix-hairpin-helix domain HTH_3 PF01381.22 CCF38321.1 - 0.021 14.9 0.0 0.11 12.5 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix BRCT PF00533.26 CCF38321.1 - 0.037 14.4 0.0 0.17 12.3 0.0 2.1 2 0 0 2 2 2 0 BRCA1 C Terminus (BRCT) domain NTP_transf_2 PF01909.23 CCF38321.1 - 0.09 13.1 0.0 0.2 12.0 0.0 1.6 1 0 0 1 1 1 0 Nucleotidyltransferase domain BRCT_2 PF16589.5 CCF38321.1 - 0.13 12.7 0.0 0.35 11.3 0.0 1.8 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain Cdd1 PF11731.8 CCF38321.1 - 0.17 12.1 0.0 17 5.7 0.0 2.9 1 1 2 3 3 3 0 Pathogenicity locus Methyltransf_2 PF00891.18 CCF38322.1 - 3.8e-24 85.2 0.0 5.8e-24 84.6 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_25 PF13649.6 CCF38322.1 - 1.2e-05 25.9 0.0 3.4e-05 24.5 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CCF38322.1 - 0.00019 21.0 0.0 0.00033 20.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain CheR PF01739.18 CCF38322.1 - 0.0064 16.0 0.0 0.0099 15.4 0.0 1.2 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain Ubie_methyltran PF01209.18 CCF38322.1 - 0.016 14.6 0.0 0.024 14.0 0.0 1.1 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 CCF38322.1 - 0.021 15.6 0.0 0.063 14.0 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_31 PF13847.6 CCF38322.1 - 0.025 14.4 0.0 0.046 13.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Glyco_hydro_43 PF04616.14 CCF38323.1 - 8.4e-32 110.6 4.6 1.4e-30 106.6 4.6 2.1 1 1 0 1 1 1 1 Glycosyl hydrolases family 43 Peptidase_S9_N PF02897.15 CCF38323.1 - 0.087 11.6 0.0 0.17 10.7 0.0 1.4 1 0 0 1 1 1 0 Prolyl oligopeptidase, N-terminal beta-propeller domain DUF2052 PF09747.9 CCF38324.1 - 2.1e-28 99.8 15.7 9.9e-16 58.5 10.2 2.1 1 1 1 2 2 2 2 Coiled-coil domain containing protein (DUF2052) Glyco_hydro_6 PF01341.17 CCF38325.1 - 1.2e-100 337.2 0.0 1.6e-100 336.8 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 6 Fimbrial_K88 PF02432.15 CCF38325.1 - 0.12 12.4 0.0 0.26 11.3 0.0 1.5 1 0 0 1 1 1 0 Fimbrial, major and minor subunit p450 PF00067.22 CCF38326.1 - 3.3e-28 98.6 0.0 3.2e-25 88.8 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 NPP1 PF05630.11 CCF38327.1 - 1.1e-33 117.0 0.8 4e-33 115.2 0.8 1.7 1 1 0 1 1 1 1 Necrosis inducing protein (NPP1) WSC PF01822.19 CCF38329.1 - 2.2e-15 56.6 1.3 2.2e-15 56.6 1.3 2.6 3 0 0 3 3 3 1 WSC domain Neisseria_TspB PF05616.13 CCF38329.1 - 9.1 4.6 10.8 17 3.7 10.8 1.4 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein APOBEC_C PF05240.14 CCF38331.1 - 0.059 13.3 0.0 0.073 13.0 0.0 1.2 1 0 0 1 1 1 0 APOBEC-like C-terminal domain Ank_2 PF12796.7 CCF38332.1 - 2.2e-36 124.3 3.4 1.9e-16 60.4 0.1 2.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CCF38332.1 - 4.6e-22 77.8 7.0 2.3e-09 37.3 0.5 3.1 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 CCF38332.1 - 6.7e-21 73.7 0.7 5.6e-05 23.4 0.1 5.1 5 0 0 5 5 5 4 Ankyrin repeat Ank_4 PF13637.6 CCF38332.1 - 7.3e-21 74.3 0.2 2.6e-08 34.3 0.0 4.1 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCF38332.1 - 3e-16 57.9 0.0 0.0071 16.8 0.0 4.4 4 0 0 4 4 4 4 Ankyrin repeat Epimerase PF01370.21 CCF38333.1 - 3.5e-27 95.4 0.0 4.8e-27 95.0 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CCF38333.1 - 2.6e-20 73.1 0.0 3.7e-20 72.6 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 CCF38333.1 - 3.5e-20 72.2 0.0 4.6e-20 71.8 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 CCF38333.1 - 1e-15 57.6 0.1 5.5e-15 55.2 0.1 1.9 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 CCF38333.1 - 6.3e-13 49.0 0.0 9.6e-13 48.4 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 CCF38333.1 - 3.7e-07 29.9 0.0 6.9e-07 29.1 0.0 1.4 1 0 0 1 1 1 1 NmrA-like family Polysacc_synt_2 PF02719.15 CCF38333.1 - 3.4e-06 26.4 0.0 4.8e-06 25.9 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein KR PF08659.10 CCF38333.1 - 6.1e-06 26.3 0.0 1.7e-05 24.8 0.0 1.7 1 1 0 1 1 1 1 KR domain adh_short PF00106.25 CCF38333.1 - 0.0014 18.1 0.0 0.0042 16.6 0.0 1.8 2 0 0 2 2 2 1 short chain dehydrogenase RmlD_sub_bind PF04321.17 CCF38333.1 - 0.057 12.5 0.0 0.21 10.7 0.0 1.8 2 0 0 2 2 2 0 RmlD substrate binding domain FA_desaturase PF00487.24 CCF38334.1 - 0.086 12.7 0.4 0.098 12.5 0.4 1.1 1 0 0 1 1 1 0 Fatty acid desaturase DUF1772 PF08592.11 CCF38335.1 - 4.7e-16 59.4 0.4 4.7e-16 59.4 0.4 2.0 1 1 1 2 2 2 2 Domain of unknown function (DUF1772) DAO PF01266.24 CCF38336.1 - 7.6e-46 157.3 4.2 9.3e-46 157.0 4.2 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 CCF38336.1 - 0.012 15.6 0.2 0.59 10.1 0.0 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 CCF38336.1 - 0.041 14.1 0.1 0.12 12.6 0.1 1.9 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Glyco_transf_28 PF03033.20 CCF38337.1 - 4.4e-18 65.7 0.0 1.2e-17 64.3 0.0 1.8 1 1 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain UDPGT PF00201.18 CCF38337.1 - 0.0034 16.2 0.0 0.0061 15.4 0.0 1.3 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase ATG_C PF09333.11 CCF38337.1 - 0.0075 16.6 0.0 0.053 13.9 0.0 2.3 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain VPS13_C PF16909.5 CCF38337.1 - 0.0089 15.8 0.6 0.02 14.7 0.1 1.8 2 0 0 2 2 2 1 Vacuolar-sorting-associated 13 protein C-terminal Glyco_tran_28_C PF04101.16 CCF38337.1 - 0.052 13.5 0.0 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 Glycosyltransferase family 28 C-terminal domain Proteasome PF00227.26 CCF38339.1 - 7.8e-46 156.0 0.0 1.1e-45 155.5 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 CCF38339.1 - 1e-13 50.7 0.3 2.1e-13 49.6 0.3 1.6 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature DUF2373 PF10180.9 CCF38340.1 - 9.9e-24 83.0 0.3 1.8e-23 82.1 0.3 1.5 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2373) zf-C2H2 PF00096.26 CCF38341.1 - 1.1e-09 38.2 23.8 3.3e-06 27.3 2.3 3.5 3 0 0 3 3 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CCF38341.1 - 1.6e-08 34.6 14.3 1.4e-07 31.6 6.1 3.5 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_jaz PF12171.8 CCF38341.1 - 3.1e-06 27.3 5.1 0.0014 18.8 0.7 2.5 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CCF38341.1 - 3.4e-06 27.2 6.0 0.00011 22.5 0.3 2.7 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 CCF38341.1 - 6.9e-06 26.5 18.9 0.00098 19.8 1.3 3.0 3 0 0 3 3 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 CCF38341.1 - 0.0025 17.8 11.3 0.025 14.6 2.9 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf_C2H2_ZHX PF18387.1 CCF38341.1 - 0.0029 17.2 4.7 0.13 11.9 0.2 2.5 1 1 1 2 2 2 2 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2_3rep PF18868.1 CCF38341.1 - 0.21 12.3 2.7 3.1 8.5 0.2 2.6 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_11 PF16622.5 CCF38341.1 - 0.25 11.1 8.1 1.5 8.6 0.2 2.8 2 0 0 2 2 2 0 zinc-finger C2H2-type zf_UBZ PF18439.1 CCF38341.1 - 0.56 9.8 5.4 5.8 6.6 0.4 3.3 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger DUF4636 PF15468.6 CCF38341.1 - 0.57 9.8 4.8 0.96 9.1 4.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4636) zf-BED PF02892.15 CCF38341.1 - 0.88 9.6 7.7 0.68 10.0 3.4 2.6 1 1 1 2 2 2 0 BED zinc finger zf-C2H2_2 PF12756.7 CCF38341.1 - 1.3 9.4 5.2 16 5.9 0.5 2.5 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) Zn-ribbon_8 PF09723.10 CCF38341.1 - 1.7 8.8 5.9 7.7 6.7 0.9 2.8 1 1 1 2 2 2 0 Zinc ribbon domain TRAM_LAG1_CLN8 PF03798.16 CCF38342.1 - 3.8e-36 124.7 18.6 7.5e-36 123.7 18.6 1.5 1 0 0 1 1 1 1 TLC domain TRAM1 PF08390.11 CCF38342.1 - 3.5e-25 87.4 0.0 7.7e-25 86.3 0.0 1.6 1 0 0 1 1 1 1 TRAM1-like protein But2 PF09792.9 CCF38344.1 - 0.0054 17.1 0.0 0.0082 16.6 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin 3 binding protein But2 C-terminal domain WD40 PF00400.32 CCF38345.1 - 8e-09 36.0 7.7 9.5e-06 26.3 0.0 7.2 7 1 0 7 7 7 1 WD domain, G-beta repeat SUR7 PF06687.12 CCF38346.1 - 4.1e-37 127.9 11.8 5.7e-37 127.4 11.8 1.2 1 0 0 1 1 1 1 SUR7/PalI family TMEM43 PF07787.12 CCF38346.1 - 0.031 13.7 0.3 0.056 12.8 0.3 1.4 1 0 0 1 1 1 0 Transmembrane protein 43 FlgD_ig PF13860.6 CCF38348.1 - 0.0082 16.0 1.9 0.012 15.5 0.0 2.1 3 0 0 3 3 3 1 FlgD Ig-like domain Dynamitin PF04912.14 CCF38349.1 - 1.8e-76 258.0 4.6 2e-76 257.8 4.6 1.0 1 0 0 1 1 1 1 Dynamitin Spore_III_AB PF09548.10 CCF38349.1 - 0.019 15.1 0.3 0.57 10.3 0.1 2.6 2 1 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) FlgN PF05130.12 CCF38349.1 - 0.022 15.2 1.0 0.022 15.2 1.0 2.0 2 0 0 2 2 2 0 FlgN protein ZapB PF06005.12 CCF38349.1 - 0.026 15.0 5.2 0.2 12.1 1.1 2.5 2 0 0 2 2 2 0 Cell division protein ZapB ATF7IP_BD PF16788.5 CCF38349.1 - 0.032 14.3 0.1 0.071 13.2 0.1 1.5 1 0 0 1 1 1 0 ATF-interacting protein binding domain FH2 PF02181.23 CCF38349.1 - 0.043 12.9 0.5 0.19 10.8 0.0 1.9 2 0 0 2 2 2 0 Formin Homology 2 Domain DASH_Spc19 PF08287.11 CCF38349.1 - 0.12 12.2 4.7 0.26 11.2 0.2 2.3 2 0 0 2 2 2 0 Spc19 KfrA_N PF11740.8 CCF38349.1 - 0.29 11.8 0.1 0.29 11.8 0.1 3.1 2 1 0 3 3 3 0 Plasmid replication region DNA-binding N-term Phage_GP20 PF06810.11 CCF38349.1 - 0.36 10.6 3.8 0.7 9.7 0.7 2.3 2 0 0 2 2 2 0 Phage minor structural protein GP20 CENP-F_leu_zip PF10473.9 CCF38349.1 - 0.41 10.7 5.0 3.7 7.6 1.0 2.3 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 SlyX PF04102.12 CCF38349.1 - 0.55 10.9 4.4 21 5.8 0.3 3.2 2 1 1 3 3 3 0 SlyX DUF1192 PF06698.11 CCF38349.1 - 1.3 9.1 6.4 1.1 9.4 0.7 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) DHR10 PF18595.1 CCF38349.1 - 2.8 8.0 10.4 11 6.2 0.5 2.8 2 1 0 2 2 2 0 Designed helical repeat protein 10 domain RTC4 PF14474.6 CCF38350.1 - 2.1e-33 115.0 0.0 4.4e-33 114.0 0.0 1.5 1 0 0 1 1 1 1 RTC4-like domain FAM193_C PF15914.5 CCF38350.1 - 0.29 10.9 0.9 0.64 9.8 0.9 1.5 1 0 0 1 1 1 0 FAM193 family C-terminal TauD PF02668.16 CCF38351.1 - 8.3e-55 186.4 0.0 1.1e-54 186.0 0.0 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family MFS_1 PF07690.16 CCF38352.1 - 1.6e-22 79.9 19.2 2.2e-22 79.5 19.2 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Zn_clus PF00172.18 CCF38353.1 - 4.1e-08 33.2 5.7 7e-08 32.5 5.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CCF38353.1 - 1.7e-07 30.5 0.0 2.9e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Alpha-amylase PF00128.24 CCF38354.1 - 3.7e-38 132.0 0.0 8.8e-38 130.7 0.0 1.5 1 1 1 2 2 2 1 Alpha amylase, catalytic domain Malt_amylase_C PF16657.5 CCF38354.1 - 3.3e-05 23.9 0.0 7.2e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 Maltogenic Amylase, C-terminal domain DUF3459 PF11941.8 CCF38354.1 - 0.00082 19.6 0.0 0.0039 17.5 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3459) Alpha-amylase_C PF02806.18 CCF38354.1 - 0.0075 16.7 0.0 0.021 15.3 0.0 1.7 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain Glyco_hydro_42C PF08533.10 CCF38354.1 - 0.07 12.9 0.0 0.62 9.8 0.0 2.5 2 1 0 2 2 2 0 Beta-galactosidase C-terminal domain Melibiase_C PF17801.1 CCF38354.1 - 0.093 12.8 0.0 0.19 11.8 0.0 1.6 1 0 0 1 1 1 0 Alpha galactosidase C-terminal beta sandwich domain CBS PF00571.28 CCF38355.1 - 3.2e-15 56.3 3.7 0.00011 22.6 0.0 5.4 5 1 0 5 5 5 3 CBS domain Zn_clus PF00172.18 CCF38357.1 - 2e-07 31.0 10.7 3.9e-07 30.1 10.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 CCF38357.1 - 3.2e-05 22.9 0.1 0.00041 19.3 0.0 2.1 2 0 0 2 2 2 1 Fungal specific transcription factor domain Calreticulin PF00262.18 CCF38357.1 - 0.021 13.7 0.1 0.035 13.0 0.1 1.2 1 0 0 1 1 1 0 Calreticulin family Terminase_4 PF05119.12 CCF38357.1 - 0.12 12.8 0.0 0.29 11.6 0.0 1.7 1 0 0 1 1 1 0 Phage terminase, small subunit p450 PF00067.22 CCF38358.1 - 1.1e-72 245.2 0.0 1.4e-72 245.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 PhoLip_ATPase_C PF16212.5 CCF38359.1 - 2.2e-54 184.9 10.1 3.1e-54 184.4 10.1 1.2 1 0 0 1 1 1 1 Phospholipid-translocating P-type ATPase C-terminal Hydrolase PF00702.26 CCF38359.1 - 2.4e-09 37.8 0.8 5.1e-07 30.2 0.0 2.4 1 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 CCF38359.1 - 0.0006 19.6 0.1 0.083 12.6 0.0 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Ribosomal_L7Ae PF01248.26 CCF38359.1 - 0.0046 16.7 0.0 0.01 15.5 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Hydrolase_6 PF13344.6 CCF38359.1 - 0.13 12.4 0.0 0.41 10.8 0.0 1.8 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Ctr PF04145.15 CCF38360.1 - 3e-28 99.3 0.4 3.9e-28 98.9 0.4 1.1 1 0 0 1 1 1 1 Ctr copper transporter family ADIP PF11559.8 CCF38361.1 - 8.3e-42 142.8 6.0 1.9e-41 141.7 6.0 1.7 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding Golgin_A5 PF09787.9 CCF38361.1 - 0.0012 18.4 1.3 0.0012 18.4 1.3 2.3 2 0 0 2 2 2 1 Golgin subfamily A member 5 DegS PF05384.11 CCF38361.1 - 0.0061 16.1 4.6 0.013 14.9 4.6 1.5 1 0 0 1 1 1 1 Sensor protein DegS SHE3 PF17078.5 CCF38361.1 - 0.042 13.6 4.3 0.95 9.1 0.1 2.5 2 0 0 2 2 2 0 SWI5-dependent HO expression protein 3 DUF641 PF04859.12 CCF38361.1 - 0.043 14.2 5.0 0.35 11.2 1.4 2.7 2 1 1 3 3 3 0 Plant protein of unknown function (DUF641) Phage_GP20 PF06810.11 CCF38361.1 - 0.12 12.1 2.3 7.3 6.4 0.8 2.6 1 1 1 2 2 2 0 Phage minor structural protein GP20 Prominin PF05478.11 CCF38361.1 - 0.56 8.1 1.6 0.88 7.4 1.6 1.2 1 0 0 1 1 1 0 Prominin Spc7 PF08317.11 CCF38361.1 - 7 5.4 13.0 0.069 12.0 4.2 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein AdoMet_MTase PF07757.13 CCF38362.1 - 1.2e-38 131.8 0.0 2.1e-38 131.1 0.0 1.4 1 0 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase DUF726 PF05277.12 CCF38364.1 - 2.6e-10 39.8 11.8 3.9e-10 39.2 11.8 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF726) p450 PF00067.22 CCF38365.1 - 1.6e-67 228.3 0.0 2e-67 228.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Sec23_trunk PF04811.15 CCF38366.1 - 6e-36 124.2 0.0 8.7e-36 123.7 0.0 1.1 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain zf-Sec23_Sec24 PF04810.15 CCF38366.1 - 4.2e-17 61.9 4.7 6.7e-17 61.2 4.7 1.3 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Vps36-NZF-N PF16988.5 CCF38366.1 - 0.016 14.5 0.1 0.036 13.4 0.1 1.5 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain Cyclin PF08613.11 CCF38368.1 - 6.1e-43 147.0 1.7 4.4e-25 88.9 0.1 2.4 2 0 0 2 2 2 2 Cyclin Glyoxalase PF00903.25 CCF38369.1 - 0.0078 16.4 0.1 0.03 14.5 0.1 1.8 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 CCF38369.1 - 0.014 16.2 0.0 0.016 16.0 0.0 1.2 1 0 0 1 1 1 0 Glyoxalase-like domain Peptidase_M16_M PF16187.5 CCF38370.1 - 5.7e-96 321.1 1.6 9.4e-96 320.4 1.6 1.4 1 0 0 1 1 1 1 Middle or third domain of peptidase_M16 Peptidase_M16_C PF05193.21 CCF38370.1 - 2.1e-34 119.1 0.1 1.7e-19 70.6 0.0 3.1 3 0 0 3 3 3 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 CCF38370.1 - 3.4e-32 111.5 0.1 1.1e-31 109.9 0.1 1.9 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) CheR_N PF03705.15 CCF38370.1 - 0.076 12.7 0.1 0.51 10.1 0.1 2.5 2 1 1 3 3 3 0 CheR methyltransferase, all-alpha domain APP_Cu_bd PF12924.7 CCF38371.1 - 0.24 12.2 2.0 27 5.6 0.0 2.9 3 0 0 3 3 3 0 Copper-binding of amyloid precursor, CuBD CotH PF08757.11 CCF38372.1 - 0.48 9.9 0.0 0.48 9.9 0.0 1.8 2 0 0 2 2 2 0 CotH kinase protein PAT1 PF09770.9 CCF38372.1 - 9.9 4.3 14.2 10 4.2 14.2 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DTHCT PF08070.11 CCF38374.1 - 0.033 14.9 14.9 0.05 14.3 14.8 1.4 1 1 0 1 1 1 0 DTHCT (NUC029) region PBP1_TM PF14812.6 CCF38374.1 - 0.35 11.3 8.7 0.53 10.7 8.3 1.6 1 1 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Myb_DNA-bind_4 PF13837.6 CCF38375.1 - 0.032 14.6 0.1 0.035 14.5 0.1 1.1 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain Fapy_DNA_glyco PF01149.24 CCF38377.1 - 1.4e-29 103.1 0.0 2.3e-29 102.3 0.0 1.4 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase N-terminal domain H2TH PF06831.14 CCF38377.1 - 1.2e-19 70.1 0.0 2e-19 69.4 0.0 1.3 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase H2TH domain FbpA PF05833.11 CCF38377.1 - 0.0039 16.0 0.0 0.074 11.8 0.0 2.1 2 0 0 2 2 2 1 Fibronectin-binding protein A N-terminus (FbpA) TFIIE-A_C PF11521.8 CCF38377.1 - 2.5 8.4 6.9 5.4 7.4 6.4 1.9 1 1 0 1 1 1 0 C-terminal general transcription factor TFIIE alpha FAD_binding_3 PF01494.19 CCF38380.1 - 3.1e-20 72.7 0.0 1.1e-19 70.9 0.0 1.7 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CCF38380.1 - 4.1e-06 26.2 0.0 0.021 14.0 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCF38380.1 - 9.6e-05 22.9 0.1 0.32 11.6 0.1 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCF38380.1 - 0.0038 17.4 0.0 0.0077 16.4 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CCF38380.1 - 0.014 15.0 0.1 0.5 9.9 0.0 2.2 2 0 0 2 2 2 0 FAD dependent oxidoreductase Trp_halogenase PF04820.14 CCF38380.1 - 0.02 13.8 0.0 0.63 8.8 0.0 2.1 2 0 0 2 2 2 0 Tryptophan halogenase OPT PF03169.15 CCF38382.1 - 9.7e-85 285.4 46.9 1.2e-84 285.1 46.9 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Bax1-I PF01027.20 CCF38384.1 - 1.2e-35 123.2 10.5 1.2e-35 123.2 10.5 2.0 2 0 0 2 2 2 1 Inhibitor of apoptosis-promoting Bax1 Haem_degrading PF03928.14 CCF38384.1 - 0.13 12.4 0.5 2.1 8.4 0.0 2.4 2 0 0 2 2 2 0 Haem-degrading DUF1686 PF07937.11 CCF38384.1 - 2.8 7.8 6.3 30 4.4 2.8 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1686) PMSR PF01625.21 CCF38385.1 - 1.4e-58 197.4 0.1 1.6e-58 197.2 0.1 1.0 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase CHRD PF07452.12 CCF38386.1 - 4.5e-09 37.3 0.0 7.5e-09 36.6 0.0 1.4 1 1 0 1 1 1 1 CHRD domain E1-E2_ATPase PF00122.20 CCF38387.1 - 1.3e-37 129.1 20.0 6.5e-32 110.5 0.0 3.9 3 1 1 4 4 4 2 E1-E2 ATPase Cation_ATPase_C PF00689.21 CCF38387.1 - 1.2e-25 90.3 5.3 1.2e-25 90.3 5.3 2.3 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 CCF38387.1 - 1.8e-16 61.1 1.1 3.6e-15 56.8 1.1 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 CCF38387.1 - 9.1e-14 50.9 0.0 2.1e-13 49.7 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 CCF38387.1 - 8.1e-13 48.3 0.0 1.7e-12 47.2 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 CCF38387.1 - 3.7e-06 26.9 1.0 4.2e-05 23.4 0.4 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase IncE PF17627.2 CCF38387.1 - 0.025 14.6 1.5 0.091 12.8 1.5 2.0 1 0 0 1 1 1 0 Inclusion membrane protein E Adap_comp_sub PF00928.21 CCF38390.1 - 5.4e-83 278.4 0.0 9.6e-83 277.6 0.0 1.4 2 0 0 2 2 2 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 CCF38390.1 - 6.1e-09 35.9 0.2 1e-08 35.2 0.2 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain TauD PF02668.16 CCF38391.1 - 8.6e-05 22.5 0.1 0.00018 21.4 0.0 1.5 2 0 0 2 2 2 1 Taurine catabolism dioxygenase TauD, TfdA family DAO PF01266.24 CCF38392.1 - 2.3e-32 112.9 0.0 2.9e-32 112.6 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CCF38392.1 - 1e-06 28.9 0.1 2.7e-06 27.5 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CCF38392.1 - 4.4e-06 26.2 0.0 0.0022 17.3 0.0 2.6 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCF38392.1 - 0.0005 20.6 0.0 0.00095 19.7 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CCF38392.1 - 0.0018 18.2 0.0 0.029 14.3 0.0 2.2 2 0 0 2 2 2 1 FAD-NAD(P)-binding FAD_binding_3 PF01494.19 CCF38392.1 - 0.0053 16.0 0.0 0.0099 15.2 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain 3HCDH_N PF02737.18 CCF38392.1 - 0.0059 16.5 0.0 0.0084 16.0 0.0 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 CCF38392.1 - 0.0089 16.2 0.0 0.015 15.5 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_Gly3P_dh_N PF01210.23 CCF38392.1 - 0.02 14.9 0.0 0.037 14.0 0.0 1.4 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus GIDA PF01134.22 CCF38392.1 - 0.021 13.9 0.0 2 7.4 0.0 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A HI0933_like PF03486.14 CCF38392.1 - 0.034 12.9 0.0 0.12 11.1 0.0 1.7 2 0 0 2 2 2 0 HI0933-like protein K_oxygenase PF13434.6 CCF38392.1 - 0.052 12.7 0.0 0.12 11.5 0.0 1.5 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) Glu_dehyd_C PF16912.5 CCF38392.1 - 0.058 12.9 0.0 0.1 12.1 0.0 1.4 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus ApbA PF02558.16 CCF38392.1 - 0.069 12.8 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA TrkA_N PF02254.18 CCF38392.1 - 0.1 12.9 0.0 0.24 11.7 0.0 1.6 2 0 0 2 2 1 0 TrkA-N domain FAD_binding_2 PF00890.24 CCF38392.1 - 0.13 11.3 0.0 0.27 10.3 0.0 1.5 1 0 0 1 1 1 0 FAD binding domain 2-Hacid_dh_C PF02826.19 CCF38392.1 - 0.16 11.3 0.0 0.26 10.6 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Thi4 PF01946.17 CCF38392.1 - 0.18 11.0 0.1 0.39 9.9 0.0 1.5 2 0 0 2 2 2 0 Thi4 family DUF4449 PF14613.6 CCF38393.1 - 6.7e-70 234.4 3.1 1.2e-69 233.6 3.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF4449) YlqD PF11068.8 CCF38393.1 - 0.073 13.5 5.1 0.099 13.0 3.8 1.9 1 1 0 1 1 1 0 YlqD protein Prp18 PF02840.15 CCF38393.1 - 0.085 12.9 0.0 0.085 12.9 0.0 2.5 3 1 1 4 4 4 0 Prp18 domain adh_short PF00106.25 CCF38394.1 - 9.1e-40 136.2 0.0 1.2e-39 135.8 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF38394.1 - 1.1e-33 116.7 0.0 5.3e-33 114.5 0.0 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF38394.1 - 0.00056 19.9 0.0 0.00078 19.4 0.0 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 CCF38394.1 - 0.13 12.1 0.2 0.24 11.3 0.2 1.5 1 1 0 1 1 1 0 NAD(P)H-binding Amidohydro_1 PF01979.20 CCF38396.1 - 7.9e-25 87.9 0.0 1.6e-23 83.6 0.0 2.2 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 CCF38396.1 - 3.7e-15 56.4 0.7 6.2e-09 35.8 0.1 2.3 2 0 0 2 2 2 2 Amidohydrolase family Aldo_ket_red PF00248.21 CCF38397.1 - 2.7e-66 223.8 0.0 3.3e-66 223.5 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family polyprenyl_synt PF00348.17 CCF38398.1 - 9.7e-51 172.3 0.0 3.3e-50 170.5 0.0 1.8 2 0 0 2 2 2 1 Polyprenyl synthetase Terpene_synth_C PF03936.16 CCF38398.1 - 0.00012 21.6 0.4 0.00098 18.5 0.1 2.3 2 0 0 2 2 2 1 Terpene synthase family, metal binding domain Phage_lysis PF03245.13 CCF38398.1 - 0.034 14.3 1.8 0.047 13.8 0.1 2.0 2 0 0 2 2 2 0 Bacteriophage Rz lysis protein Phage_TAC_11 PF11836.8 CCF38398.1 - 0.044 13.9 0.1 0.12 12.5 0.1 1.7 1 0 0 1 1 1 0 Phage tail tube protein, GTA-gp10 DUF4376 PF14301.6 CCF38398.1 - 0.14 12.6 1.0 3.3 8.1 0.3 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4376) DUF4650 PF15509.6 CCF38398.1 - 0.14 11.5 2.6 0.21 10.9 2.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4650) p450 PF00067.22 CCF38399.1 - 2.7e-52 178.1 0.0 4e-52 177.5 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 Ribosomal_L16 PF00252.18 CCF38399.1 - 0.094 12.7 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L16p/L10e DUF3328 PF11807.8 CCF38400.1 - 3.6e-36 125.0 1.5 5.4e-36 124.4 1.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Cypo_polyhedrin PF05865.11 CCF38400.1 - 0.047 13.1 0.1 0.077 12.4 0.1 1.3 1 0 0 1 1 1 0 Cypovirus polyhedrin protein ADH_zinc_N PF00107.26 CCF38401.1 - 0.0019 18.2 0.3 0.0033 17.4 0.3 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase SR-25 PF10500.9 CCF38401.1 - 0.018 14.7 6.9 0.027 14.1 6.9 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein IMUP PF15761.5 CCF38401.1 - 0.46 11.2 5.6 0.85 10.3 5.6 1.4 1 0 0 1 1 1 0 Immortalisation up-regulated protein UbiA PF01040.18 CCF38402.1 - 2.9e-31 108.7 15.9 4.2e-31 108.1 15.9 1.3 1 0 0 1 1 1 1 UbiA prenyltransferase family LCM PF04072.14 CCF38403.1 - 0.00013 22.0 0.0 0.00016 21.6 0.0 1.1 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase NUC153 PF08159.12 CCF38404.1 - 5.4e-11 42.1 1.8 1.4e-10 40.8 1.8 1.7 1 0 0 1 1 1 1 NUC153 domain WD40 PF00400.32 CCF38404.1 - 7e-05 23.5 0.2 10 7.2 0.0 4.1 5 0 0 5 5 5 2 WD domain, G-beta repeat ETS_PEA3_N PF04621.13 CCF38406.1 - 1.4 8.8 5.2 11 5.8 0.0 2.2 2 0 0 2 2 2 0 PEA3 subfamily ETS-domain transcription factor N terminal domain Sugar_tr PF00083.24 CCF38408.1 - 2.7e-29 102.3 35.4 2.1e-18 66.4 10.0 2.9 2 1 1 3 3 3 3 Sugar (and other) transporter MFS_1 PF07690.16 CCF38408.1 - 7e-22 77.8 26.4 2.1e-15 56.5 15.9 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily Dynamin_N PF00350.23 CCF38409.1 - 5.5e-31 107.9 0.0 1.3e-30 106.7 0.0 1.7 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 CCF38409.1 - 5.1e-24 85.0 0.0 1.7e-21 76.7 0.0 2.2 2 0 0 2 2 2 2 Dynamin central region MMR_HSR1 PF01926.23 CCF38409.1 - 0.0025 17.9 0.0 0.017 15.2 0.0 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 CCF38409.1 - 0.0097 16.3 0.1 0.039 14.3 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain GED PF02212.18 CCF38409.1 - 0.013 15.6 0.8 0.084 13.0 0.1 2.5 2 0 0 2 2 2 0 Dynamin GTPase effector domain AAA_21 PF13304.6 CCF38409.1 - 0.09 12.6 0.1 1.1 9.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system Chitin_synth_2 PF03142.15 CCF38410.1 - 1.1e-42 146.3 4.7 1.3e-33 116.4 0.9 2.3 2 1 0 2 2 2 2 Chitin synthase Glycos_transf_2 PF00535.26 CCF38410.1 - 7.1e-08 32.4 0.0 0.0045 16.8 0.0 2.4 2 0 0 2 2 2 2 Glycosyl transferase family 2 Glyco_trans_2_3 PF13632.6 CCF38410.1 - 1.1e-05 25.4 11.1 1.6e-05 24.9 4.8 3.2 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 CCF38410.1 - 0.00043 20.2 0.0 0.97 9.3 0.0 3.0 3 0 0 3 3 3 2 Glycosyltransferase like family 2 PHO4 PF01384.20 CCF38410.1 - 0.9 8.5 2.5 1.4 7.9 1.0 1.8 2 0 0 2 2 2 0 Phosphate transporter family p450 PF00067.22 CCF38412.1 - 1.4e-72 244.9 0.0 1.8e-72 244.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 DUF3377 PF11857.8 CCF38413.1 - 0.01 15.7 3.9 15 5.6 0.0 4.3 4 0 0 4 4 4 0 Domain of unknown function (DUF3377) CrgA PF06781.12 CCF38413.1 - 0.11 12.5 1.7 0.55 10.3 0.0 3.1 3 2 0 3 3 3 0 Cell division protein CrgA CLTH PF10607.9 CCF38414.1 - 9.6e-32 109.9 0.0 1.8e-31 109.0 0.0 1.5 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain zf-RING_UBOX PF13445.6 CCF38414.1 - 8.4e-10 38.5 2.6 1.5e-09 37.7 2.6 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 CCF38414.1 - 7.6e-07 29.0 2.1 1.3e-06 28.3 2.1 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 CCF38414.1 - 5.7e-05 22.9 2.1 9.7e-05 22.2 2.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CCF38414.1 - 5.9e-05 23.3 2.8 0.0001 22.6 2.8 1.4 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 CCF38414.1 - 0.00011 22.0 2.5 0.0002 21.1 2.5 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 CCF38414.1 - 0.00039 20.2 3.5 0.00072 19.4 3.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CCF38414.1 - 0.00062 19.5 3.9 0.0012 18.7 3.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Rtf2 PF04641.12 CCF38414.1 - 0.002 17.5 0.1 0.0033 16.8 0.1 1.3 1 0 0 1 1 1 1 Rtf2 RING-finger zf-C3HC4_4 PF15227.6 CCF38414.1 - 0.0044 17.2 3.4 0.0089 16.2 3.4 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 CCF38414.1 - 0.097 12.5 2.0 0.17 11.7 2.0 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C2HC5 PF06221.13 CCF38414.1 - 0.12 12.4 0.3 0.24 11.4 0.3 1.4 1 0 0 1 1 1 0 Putative zinc finger motif, C2HC5-type Ctr PF04145.15 CCF38415.1 - 2.4e-38 132.0 0.2 3.1e-38 131.7 0.2 1.1 1 0 0 1 1 1 1 Ctr copper transporter family YfhO PF09586.10 CCF38415.1 - 0.24 9.6 5.6 0.42 8.8 5.6 1.3 1 0 0 1 1 1 0 Bacterial membrane protein YfhO Hemerythrin PF01814.23 CCF38416.1 - 1.6e-07 32.0 0.0 2e-07 31.7 0.0 1.2 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain Peptidase_C12 PF01088.21 CCF38417.1 - 2.5e-48 164.6 0.0 3e-48 164.4 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 TPR_1 PF00515.28 CCF38418.1 - 4.7e-45 149.6 20.3 1.3e-07 31.1 0.2 9.5 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_2 PF07719.17 CCF38418.1 - 5.2e-37 123.0 22.3 1.6e-05 24.7 0.1 9.7 9 0 0 9 9 9 8 Tetratricopeptide repeat STI1 PF17830.1 CCF38418.1 - 2.3e-31 107.5 11.5 1.3e-16 60.3 1.1 3.0 2 0 0 2 2 2 2 STI1 domain TPR_11 PF13414.6 CCF38418.1 - 2.5e-21 75.1 21.5 0.00077 19.1 0.3 8.6 6 2 3 9 9 9 7 TPR repeat TPR_8 PF13181.6 CCF38418.1 - 1.7e-19 68.3 25.7 3.8e-05 23.6 0.2 8.2 9 0 0 9 9 7 5 Tetratricopeptide repeat TPR_16 PF13432.6 CCF38418.1 - 2.4e-16 60.1 8.2 0.00072 20.2 0.0 6.3 4 3 2 6 6 6 3 Tetratricopeptide repeat TPR_12 PF13424.6 CCF38418.1 - 2.4e-15 56.6 16.3 2.7e-11 43.6 0.7 5.3 3 2 2 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 CCF38418.1 - 3.4e-15 54.9 11.8 2.8e-05 23.8 0.1 7.4 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_17 PF13431.6 CCF38418.1 - 2.3e-13 49.5 6.0 0.59 10.6 0.1 7.8 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_9 PF13371.6 CCF38418.1 - 2.8e-13 49.8 0.5 0.00037 20.6 0.0 5.2 4 2 2 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 CCF38418.1 - 1.8e-12 47.6 12.9 7.7e-05 23.1 0.0 6.2 5 1 1 6 6 6 4 Tetratricopeptide repeat TPR_14 PF13428.6 CCF38418.1 - 1.3e-11 44.2 11.6 4.2 8.4 0.1 8.3 5 3 2 8 8 7 2 Tetratricopeptide repeat TPR_6 PF13174.6 CCF38418.1 - 3.5e-07 30.4 7.3 0.79 10.5 0.0 7.3 6 1 0 6 6 6 2 Tetratricopeptide repeat TPR_10 PF13374.6 CCF38418.1 - 6.9e-05 22.6 17.1 0.015 15.2 0.1 6.3 6 1 1 7 7 6 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 CCF38418.1 - 0.00014 21.2 0.7 0.57 9.7 0.1 4.2 4 0 0 4 4 4 1 SHNi-TPR ANAPC3 PF12895.7 CCF38418.1 - 0.019 15.2 4.0 0.025 14.8 0.9 2.7 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPM_phosphatase PF04536.14 CCF38418.1 - 0.037 14.2 4.0 13 6.0 0.0 4.2 4 0 0 4 4 4 0 TPM domain DUF5486 PF17588.2 CCF38418.1 - 0.093 12.6 3.2 0.63 10.0 1.2 2.7 2 0 0 2 2 2 0 Family of unknown function (DUF5486) DUF3658 PF12395.8 CCF38418.1 - 0.11 12.5 0.6 3.5 7.6 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function TPR_3 PF07720.12 CCF38418.1 - 0.14 12.2 0.2 0.14 12.2 0.2 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat RPN7 PF10602.9 CCF38418.1 - 0.17 11.6 4.3 0.77 9.4 1.4 3.4 2 2 1 3 3 3 0 26S proteasome subunit RPN7 MIT PF04212.18 CCF38418.1 - 2.7 8.1 21.3 3.3 7.8 2.4 6.1 5 1 0 5 5 5 0 MIT (microtubule interacting and transport) domain MFS_1 PF07690.16 CCF38419.1 - 1.4e-39 136.1 49.0 1.4e-39 136.1 49.0 2.3 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 CCF38419.1 - 1.9e-08 33.2 26.3 2.5e-08 32.8 26.3 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) SSP160 PF06933.11 CCF38420.1 - 0.017 13.4 11.4 0.027 12.7 11.4 1.3 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 YqfQ PF14181.6 CCF38420.1 - 0.31 11.2 6.2 0.56 10.4 6.2 1.4 1 0 0 1 1 1 0 YqfQ-like protein Adaptin_N PF01602.20 CCF38421.1 - 1.4e-123 413.3 3.6 1.5e-123 413.1 3.6 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 CCF38421.1 - 2.1e-10 40.9 6.3 3.6e-06 27.1 0.1 4.1 2 1 2 4 4 4 2 non-SMC mitotic condensation complex subunit 1 DUF3730 PF12530.8 CCF38421.1 - 1.7e-08 34.3 1.1 5.5e-05 22.8 0.1 2.9 1 1 2 3 3 3 2 Protein of unknown function (DUF3730) HEAT_2 PF13646.6 CCF38421.1 - 4.5e-06 27.0 0.4 0.48 10.8 0.0 3.8 2 2 2 4 4 4 2 HEAT repeats HEAT PF02985.22 CCF38421.1 - 0.00049 20.1 2.9 2.2 8.7 0.1 4.6 4 1 1 5 5 5 1 HEAT repeat TIP120 PF08623.10 CCF38421.1 - 0.003 17.3 0.3 1.5 8.6 0.1 3.0 2 2 1 3 3 3 2 TATA-binding protein interacting (TIP20) RIX1 PF08167.12 CCF38421.1 - 0.015 15.1 0.1 0.19 11.4 0.0 2.5 2 1 1 3 3 3 0 rRNA processing/ribosome biogenesis HEAT_EZ PF13513.6 CCF38421.1 - 0.029 14.9 3.5 28 5.3 0.0 4.8 4 2 0 4 4 4 0 HEAT-like repeat Vac14_Fab1_bd PF12755.7 CCF38421.1 - 0.041 14.5 0.6 1.9 9.1 0.1 3.5 2 1 1 3 3 3 0 Vacuolar 14 Fab1-binding region Cohesin_HEAT PF12765.7 CCF38421.1 - 0.082 13.2 0.7 0.3 11.4 0.1 2.4 2 0 0 2 2 2 0 HEAT repeat associated with sister chromatid cohesion RICTOR_M PF14666.6 CCF38421.1 - 0.12 12.2 0.4 0.41 10.5 0.0 2.2 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, middle domain EF-hand_1 PF00036.32 CCF38422.1 - 1.1e-41 137.3 12.9 7.8e-10 37.6 0.9 4.1 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 CCF38422.1 - 3.5e-36 123.5 5.8 3.9e-19 68.9 2.2 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 CCF38422.1 - 6.8e-35 118.7 11.4 2.3e-15 56.1 0.6 4.0 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 CCF38422.1 - 2.1e-30 102.0 9.5 1.9e-09 36.7 0.2 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 CCF38422.1 - 6.5e-26 88.6 10.6 2.6e-06 26.7 0.3 4.3 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 CCF38422.1 - 1.5e-16 60.5 0.4 2.3e-09 37.4 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 CCF38422.1 - 3.4e-09 36.6 1.9 0.00075 19.4 0.2 2.3 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 CCF38422.1 - 5.6e-09 36.3 0.2 0.0016 18.7 0.1 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region UPF0154 PF03672.13 CCF38422.1 - 9.9e-07 28.7 0.0 0.0077 16.2 0.0 3.0 2 1 1 3 3 3 2 Uncharacterised protein family (UPF0154) EFhand_Ca_insen PF08726.10 CCF38422.1 - 5.8e-06 26.3 1.6 2.3e-05 24.4 0.2 2.3 2 1 0 2 2 2 1 Ca2+ insensitive EF hand EF-hand_11 PF08976.11 CCF38422.1 - 9.1e-05 23.3 0.2 0.0022 18.8 0.1 2.0 1 1 1 2 2 2 1 EF-hand domain TerB PF05099.13 CCF38422.1 - 0.00012 22.0 0.3 0.35 10.8 0.0 2.2 1 1 1 2 2 2 2 Tellurite resistance protein TerB Caleosin PF05042.13 CCF38422.1 - 0.00045 20.2 1.8 0.44 10.5 0.0 3.5 1 1 3 4 4 4 1 Caleosin related protein RNA_pol_Rpb4 PF03874.16 CCF38422.1 - 0.00062 20.1 0.8 0.66 10.3 0.1 2.7 2 1 1 3 3 3 2 RNA polymerase Rpb4 DUF3349 PF11829.8 CCF38422.1 - 0.0014 19.3 0.4 3.7 8.4 0.0 2.9 1 1 2 3 3 3 1 Protein of unknown function (DUF3349) Dockerin_1 PF00404.18 CCF38422.1 - 0.0053 16.9 7.0 0.38 11.0 0.8 2.9 1 1 2 3 3 3 2 Dockerin type I domain DUF5580 PF17743.1 CCF38422.1 - 0.006 15.2 0.0 0.0062 15.1 0.0 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5580) SurA_N_2 PF13623.6 CCF38422.1 - 0.0091 15.9 0.9 0.32 10.9 0.1 2.2 1 1 1 2 2 2 1 SurA N-terminal domain EF-hand_14 PF17959.1 CCF38422.1 - 0.012 16.0 0.5 6.2 7.2 0.1 2.4 1 1 1 2 2 2 0 EF-hand domain Poly_export PF02563.16 CCF38422.1 - 0.023 14.9 0.0 0.18 12.1 0.0 2.5 2 1 0 2 2 2 0 Polysaccharide biosynthesis/export protein DUF4497 PF14924.6 CCF38422.1 - 0.036 14.5 0.0 8.7 6.9 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4497) RuvA_C PF07499.13 CCF38422.1 - 0.058 13.9 0.1 8.5 6.9 0.0 3.0 3 0 0 3 3 3 0 RuvA, C-terminal domain MotA_activ PF09114.10 CCF38422.1 - 0.061 13.4 0.3 1.2 9.3 0.0 2.3 1 1 0 2 2 2 0 Transcription factor MotA, activation domain dCache_2 PF08269.11 CCF38422.1 - 0.066 12.4 0.1 1.1 8.4 0.1 2.1 1 1 1 2 2 2 0 Cache domain DUF5132 PF17195.4 CCF38422.1 - 0.15 12.2 0.5 21 5.3 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF5132) RloB PF13707.6 CCF38422.1 - 0.16 12.2 1.1 0.76 9.9 0.2 2.0 1 1 1 2 2 2 0 RloB-like protein CFEM PF05730.11 CCF38423.1 - 0.00012 22.1 3.4 0.00017 21.6 3.4 1.3 1 0 0 1 1 1 1 CFEM domain TMEM37 PF15108.6 CCF38423.1 - 0.036 14.0 1.3 0.054 13.4 1.3 1.2 1 0 0 1 1 1 0 Voltage-dependent calcium channel gamma-like subunit protein family Defensin_2 PF01097.18 CCF38423.1 - 0.15 12.0 4.0 0.26 11.2 4.0 1.4 1 0 0 1 1 1 0 Arthropod defensin DUF202 PF02656.15 CCF38423.1 - 0.34 11.4 0.1 0.34 11.4 0.1 2.4 2 1 1 3 3 3 0 Domain of unknown function (DUF202) GST_N_3 PF13417.6 CCF38424.1 - 0.00043 20.6 0.0 0.00093 19.6 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CCF38424.1 - 0.055 13.8 0.0 0.12 12.7 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Sugar_tr PF00083.24 CCF38428.1 - 1.5e-29 103.2 7.8 2.4e-29 102.5 4.3 1.9 2 0 0 2 2 2 2 Sugar (and other) transporter RNase_H PF00075.24 CCF38429.1 - 6e-10 39.5 0.0 9e-10 38.9 0.0 1.3 1 0 0 1 1 1 1 RNase H RVT_3 PF13456.6 CCF38429.1 - 0.08 12.8 0.3 0.18 11.6 0.3 1.5 1 1 0 1 1 1 0 Reverse transcriptase-like Zn_clus PF00172.18 CCF38430.1 - 2e-08 34.2 10.3 3.2e-08 33.5 10.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 CCF38430.1 - 0.0031 16.4 0.7 0.035 12.9 0.2 2.2 2 0 0 2 2 2 1 Fungal specific transcription factor domain DUF2183 PF09949.9 CCF38431.1 - 1.3e-31 108.8 0.1 4.1e-31 107.3 0.0 1.9 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2183) Pox_A12 PF04651.13 CCF38434.1 - 0.074 13.1 3.2 0.12 12.5 3.2 1.3 1 0 0 1 1 1 0 Poxvirus A12 protein Pex2_Pex12 PF04757.14 CCF38435.1 - 8.4e-41 140.0 1.9 1.1e-40 139.7 1.9 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_2 PF13923.6 CCF38435.1 - 8.6e-12 44.7 8.4 1.3e-11 44.1 8.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CCF38435.1 - 4.9e-11 42.8 8.7 7.4e-11 42.2 8.7 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 CCF38435.1 - 3.6e-10 39.5 6.1 5.5e-10 39.0 6.1 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CCF38435.1 - 4.1e-10 39.4 6.4 6.3e-10 38.8 6.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CCF38435.1 - 1.2e-07 31.6 6.8 2.4e-07 30.7 6.8 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.7 CCF38435.1 - 3.7e-07 30.3 5.8 6.7e-07 29.5 5.8 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 CCF38435.1 - 5e-07 29.6 5.5 8e-07 28.9 5.5 1.3 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 CCF38435.1 - 1.9e-06 27.6 6.9 3.1e-06 26.9 6.9 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 CCF38435.1 - 4.7e-06 26.7 7.7 7.7e-06 26.0 7.7 1.3 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_10 PF16685.5 CCF38435.1 - 0.00059 19.9 5.9 0.001 19.2 5.9 1.3 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-RING_6 PF14835.6 CCF38435.1 - 0.001 18.9 2.4 0.0018 18.1 2.4 1.3 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-Nse PF11789.8 CCF38435.1 - 0.0077 16.0 0.5 0.012 15.4 0.5 1.3 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_4 PF14570.6 CCF38435.1 - 0.05 13.4 6.2 0.11 12.4 6.2 1.5 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-ANAPC11 PF12861.7 CCF38435.1 - 0.055 13.5 1.6 0.097 12.7 1.6 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 CCF38435.1 - 0.34 10.7 3.3 0.69 9.7 3.3 1.6 1 0 0 1 1 1 0 RING-like zinc finger CN_hydrolase PF00795.22 CCF38436.1 - 2.8e-41 141.6 0.0 3.1e-41 141.4 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Rep_fac-A_3 PF08661.11 CCF38438.1 - 1.5e-19 70.3 0.0 1.6e-19 70.2 0.0 1.0 1 0 0 1 1 1 1 Replication factor A protein 3 GST_N PF02798.20 CCF38439.1 - 2.5e-07 30.9 0.0 4.7e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 CCF38439.1 - 2.6e-07 31.0 0.0 5.6e-07 29.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CCF38439.1 - 1e-06 28.9 0.0 1.8e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 CCF38439.1 - 4e-06 27.0 0.0 8.1e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CCF38439.1 - 1.4e-05 25.0 0.3 6.5e-05 22.9 0.0 2.1 1 1 1 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 CCF38439.1 - 4.9e-05 23.5 0.0 9.8e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Fungal_trans PF04082.18 CCF38440.1 - 2.5e-28 98.9 0.0 3.5e-28 98.4 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF38440.1 - 3.7e-07 30.2 8.9 7.6e-07 29.2 8.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SIR2 PF02146.17 CCF38441.1 - 7e-40 136.8 0.0 1.2e-39 136.1 0.0 1.3 1 1 0 1 1 1 1 Sir2 family TPP_enzyme_M PF00205.22 CCF38441.1 - 0.048 13.4 0.0 1.8 8.3 0.0 2.3 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain ADH_zinc_N PF00107.26 CCF38442.1 - 1.1e-22 80.3 0.0 2e-22 79.5 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCF38442.1 - 6.4e-20 71.1 6.5 1.1e-19 70.4 6.5 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 CCF38442.1 - 4.1e-07 31.1 0.0 6.5e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 CCF38442.1 - 2.2e-05 23.9 1.0 3.6e-05 23.1 0.7 1.5 1 1 1 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 CCF38442.1 - 0.00031 20.1 0.3 0.00049 19.5 0.3 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Gag_MA PF01140.19 CCF38442.1 - 0.011 15.5 0.0 0.023 14.4 0.0 1.5 1 0 0 1 1 1 0 Matrix protein (MA), p15 Shikimate_DH PF01488.20 CCF38442.1 - 0.089 12.9 0.0 0.14 12.2 0.0 1.2 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Glyco_transf_28 PF03033.20 CCF38444.1 - 0.034 14.2 0.0 0.065 13.3 0.0 1.5 1 0 0 1 1 1 0 Glycosyltransferase family 28 N-terminal domain UDPGT PF00201.18 CCF38444.1 - 0.09 11.6 0.0 0.15 10.8 0.0 1.3 1 0 0 1 1 1 0 UDP-glucoronosyl and UDP-glucosyl transferase FMO-like PF00743.19 CCF38445.1 - 2e-15 56.2 0.3 2e-14 52.9 0.0 2.2 2 1 0 2 2 2 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 CCF38445.1 - 2.3e-12 46.9 0.0 9.1e-12 45.0 0.0 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 CCF38445.1 - 6.5e-10 38.8 0.6 1.5e-08 34.2 0.7 2.7 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CCF38445.1 - 1.1e-08 34.7 0.0 4e-07 29.6 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CCF38445.1 - 1.4e-05 24.4 0.4 0.00012 21.4 0.0 2.2 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 CCF38445.1 - 1.8e-05 24.8 0.1 0.02 14.9 0.0 3.6 3 0 0 3 3 3 1 FAD-NAD(P)-binding DAO PF01266.24 CCF38445.1 - 0.00012 21.8 2.5 0.0033 17.1 2.5 2.9 1 1 0 1 1 1 1 FAD dependent oxidoreductase Mqo PF06039.15 CCF38445.1 - 0.0061 15.2 0.3 0.63 8.5 0.0 2.3 2 0 0 2 2 2 2 Malate:quinone oxidoreductase (Mqo) Thi4 PF01946.17 CCF38445.1 - 0.007 15.6 0.3 0.031 13.5 0.1 2.1 3 0 0 3 3 3 1 Thi4 family Shikimate_DH PF01488.20 CCF38445.1 - 0.016 15.3 0.0 3.9 7.5 0.0 3.6 4 0 0 4 4 4 0 Shikimate / quinate 5-dehydrogenase AlaDh_PNT_C PF01262.21 CCF38445.1 - 0.073 12.4 0.2 1.6 8.0 0.4 2.2 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 CCF38445.1 - 1.4 7.5 2.6 5.1 5.7 1.0 2.3 3 0 0 3 3 3 0 HI0933-like protein Pkinase PF00069.25 CCF38447.1 - 3.8e-13 49.4 0.0 1.9e-12 47.2 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF38447.1 - 2.6e-07 30.2 0.0 4.3e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Methyltransf_23 PF13489.6 CCF38448.1 - 3.7e-10 39.9 0.0 3.9e-10 39.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF38448.1 - 1.6e-09 38.4 0.1 1.4e-08 35.3 0.1 2.3 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF38448.1 - 3.5e-06 26.9 0.2 8.5e-05 22.4 0.2 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF38448.1 - 2.1e-05 25.2 0.4 0.00044 21.0 0.2 2.6 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF38448.1 - 2.2e-05 25.0 0.0 4.7e-05 24.0 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 CCF38448.1 - 0.00076 18.8 0.0 0.00094 18.5 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase domain MTS PF05175.14 CCF38448.1 - 0.0014 18.2 0.0 0.0022 17.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.17 CCF38448.1 - 0.0089 15.5 0.0 0.013 14.9 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase FtsJ PF01728.19 CCF38448.1 - 0.015 15.4 0.0 0.017 15.2 0.0 1.1 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_16 PF10294.9 CCF38448.1 - 0.02 14.6 0.0 0.023 14.4 0.0 1.1 1 0 0 1 1 1 0 Lysine methyltransferase PrmA PF06325.13 CCF38448.1 - 0.022 14.2 0.0 0.028 13.8 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) CMAS PF02353.20 CCF38448.1 - 0.026 13.8 0.0 0.029 13.7 0.0 1.1 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.18 CCF38448.1 - 0.096 12.0 0.0 0.33 10.3 0.0 1.9 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family DIOX_N PF14226.6 CCF38449.1 - 4.1e-27 95.3 0.2 6.7e-27 94.6 0.2 1.5 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 CCF38449.1 - 3.7e-24 85.1 0.0 1.1e-23 83.7 0.0 1.8 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Transp_cyt_pur PF02133.15 CCF38450.1 - 1.5e-45 155.8 22.5 1.9e-45 155.5 22.5 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin MFS_1 PF07690.16 CCF38454.1 - 8.6e-24 84.1 20.9 8.6e-24 84.1 20.9 1.5 1 1 1 2 2 2 1 Major Facilitator Superfamily Mito_carr PF00153.27 CCF38456.1 - 6.7e-26 90.1 1.2 5.9e-14 51.8 0.1 2.1 2 0 0 2 2 2 2 Mitochondrial carrier protein Fungal_trans PF04082.18 CCF38457.1 - 4.2e-57 193.2 0.1 6e-57 192.7 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 CCF38457.1 - 4.8e-08 33.0 4.1 0.0016 18.8 0.2 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type FOXP-CC PF16159.5 CCF38457.1 - 0.011 16.3 0.2 2.1 9.0 0.1 2.6 2 0 0 2 2 2 0 FOXP coiled-coil domain zf-C2H2_4 PF13894.6 CCF38457.1 - 0.31 12.0 10.7 0.58 11.1 0.2 3.2 3 0 0 3 3 3 0 C2H2-type zinc finger p450 PF00067.22 CCF38459.1 - 5e-52 177.2 0.0 6e-52 176.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 TRI12 PF06609.13 CCF38461.1 - 0.00013 20.6 2.8 0.00018 20.1 2.4 1.5 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) GPHR_N PF12537.8 CCF38461.1 - 0.038 14.1 0.5 0.069 13.2 0.3 1.6 1 1 1 2 2 2 0 The Golgi pH Regulator (GPHR) Family N-terminal DUF4235 PF14019.6 CCF38461.1 - 0.19 11.8 1.1 0.56 10.3 0.1 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF4235) Phage_holin_3_6 PF07332.11 CCF38461.1 - 5.2 7.1 7.9 0.78 9.8 3.3 1.8 1 1 1 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Zn_clus PF00172.18 CCF38462.1 - 2.5e-08 33.9 10.6 3.3e-08 33.5 10.6 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain p450 PF00067.22 CCF38463.1 - 4.9e-14 51.9 0.0 5.7e-14 51.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF924 PF06041.11 CCF38464.1 - 3.1e-48 164.3 0.2 4.3e-48 163.8 0.2 1.2 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF924) Amidohydro_3 PF07969.11 CCF38465.1 - 1.1e-73 249.3 2.7 1.3e-73 249.1 2.7 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_1 PF01979.20 CCF38465.1 - 1.4e-12 47.6 0.0 1.3e-08 34.6 0.0 3.2 2 1 0 2 2 2 2 Amidohydrolase family Fungal_trans PF04082.18 CCF38466.1 - 1.3e-10 40.8 0.0 2.1e-10 40.1 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF38466.1 - 2.8e-07 30.6 5.4 5.2e-07 29.7 5.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Transp_cyt_pur PF02133.15 CCF38467.1 - 1.1e-40 139.7 24.4 8.3e-24 84.1 11.8 2.0 1 1 1 2 2 2 2 Permease for cytosine/purines, uracil, thiamine, allantoin DUF917 PF06032.12 CCF38468.1 - 3e-70 236.8 0.0 6.7e-70 235.7 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF917) Hydant_A_N PF05378.13 CCF38468.1 - 3.6e-29 101.7 4.7 1.8e-26 92.9 0.3 3.3 3 1 0 3 3 3 2 Hydantoinase/oxoprolinase N-terminal region Hydantoinase_A PF01968.18 CCF38468.1 - 3.5e-21 75.7 14.4 1.6e-11 44.0 5.9 4.2 3 1 0 3 3 3 2 Hydantoinase/oxoprolinase MutL PF13941.6 CCF38468.1 - 8.7e-06 24.6 2.9 0.031 12.9 0.9 2.5 2 0 0 2 2 2 2 MutL protein StbA PF06406.11 CCF38468.1 - 0.00075 18.8 0.1 0.46 9.7 0.0 2.6 2 0 0 2 2 2 2 StbA protein BcrAD_BadFG PF01869.20 CCF38468.1 - 0.0024 17.4 3.3 0.035 13.6 0.7 2.5 2 1 0 2 2 2 1 BadF/BadG/BcrA/BcrD ATPase family FtsA PF14450.6 CCF38468.1 - 0.015 15.7 0.0 18 5.8 0.1 3.7 3 1 0 3 3 3 0 Cell division protein FtsA ROK PF00480.20 CCF38468.1 - 0.017 14.6 0.1 0.065 12.7 0.2 1.9 2 0 0 2 2 2 0 ROK family DUF3663 PF12404.8 CCF38468.1 - 0.14 12.3 0.1 0.32 11.1 0.1 1.5 1 0 0 1 1 1 0 Peptidase Zn_clus PF00172.18 CCF38469.1 - 2.4e-08 33.9 8.4 4.2e-08 33.2 8.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_hydro_16 PF00722.21 CCF38470.1 - 5.4e-13 48.8 0.1 7.3e-13 48.4 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 SKN1 PF03935.15 CCF38470.1 - 3.7e-05 22.3 2.8 0.036 12.5 2.5 2.1 2 0 0 2 2 2 2 Beta-glucan synthesis-associated protein (SKN1) DHH PF01368.20 CCF38471.1 - 0.012 15.9 0.1 0.02 15.1 0.1 1.4 1 0 0 1 1 1 0 DHH family Glyco_hydro_16 PF00722.21 CCF38474.1 - 1.1e-08 34.7 0.2 2e-05 24.1 0.1 2.2 2 0 0 2 2 2 2 Glycosyl hydrolases family 16 SKN1 PF03935.15 CCF38474.1 - 6.4e-06 24.8 0.0 0.007 14.8 0.2 2.1 2 0 0 2 2 2 2 Beta-glucan synthesis-associated protein (SKN1) HSP70 PF00012.20 CCF38476.1 - 5.9e-19 67.7 2.6 6.2e-19 67.6 2.6 1.0 1 0 0 1 1 1 1 Hsp70 protein Paralemmin PF03285.15 CCF38476.1 - 0.013 15.1 1.3 0.036 13.6 1.0 1.6 1 1 0 1 1 1 0 Paralemmin 2OG-FeII_Oxy PF03171.20 CCF38479.1 - 0.0001 22.7 0.0 0.011 16.2 0.0 2.3 2 0 0 2 2 2 2 2OG-Fe(II) oxygenase superfamily ECH_2 PF16113.5 CCF38481.1 - 1.1e-113 380.2 0.0 6.2e-96 321.8 0.0 2.2 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 CCF38481.1 - 1.5e-27 96.5 0.0 1.7e-26 93.1 0.0 2.4 3 0 0 3 3 3 1 Enoyl-CoA hydratase/isomerase TFIIA PF03153.13 CCF38482.1 - 1 9.3 21.8 1.2 9.0 21.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit MFS_1 PF07690.16 CCF38484.1 - 1.6e-33 116.1 31.3 2.3e-33 115.6 31.3 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily MgtE PF01769.16 CCF38486.1 - 0.051 14.0 9.8 0.09 13.2 9.8 1.4 1 0 0 1 1 1 0 Divalent cation transporter FA_desaturase PF00487.24 CCF38486.1 - 1.1 9.0 8.6 1.7 8.4 8.6 1.3 1 0 0 1 1 1 0 Fatty acid desaturase DUF2207 PF09972.9 CCF38486.1 - 1.2 7.8 13.9 1.5 7.5 13.9 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) tRNA_anti-like PF12869.7 CCF38486.1 - 8.2 6.0 12.7 6.1e+02 -0.1 12.7 2.3 1 1 0 1 1 1 0 tRNA_anti-like DUF4122 PF13498.6 CCF38489.1 - 0.1 12.3 0.0 0.16 11.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4122) WD40 PF00400.32 CCF38490.1 - 8.2e-34 115.1 7.8 2e-07 31.6 0.2 7.0 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF38490.1 - 2.1e-13 50.4 0.3 1.1e-05 25.6 0.0 4.2 3 2 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CCF38490.1 - 0.011 15.6 0.3 1.2 8.9 0.0 2.9 2 1 1 3 3 3 0 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 CCF38490.1 - 0.015 14.3 1.1 7.7 5.4 0.0 3.3 2 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 CCF38490.1 - 0.028 13.1 1.0 0.75 8.4 0.0 2.6 1 1 2 3 3 3 0 Nucleoporin Nup120/160 SSXRD PF09514.10 CCF38490.1 - 1.4 8.6 6.2 5.4 6.7 6.2 2.1 1 0 0 1 1 1 0 SSXRD motif Cornichon PF03311.14 CCF38491.1 - 3.1e-50 169.6 13.0 3.6e-50 169.4 13.0 1.0 1 0 0 1 1 1 1 Cornichon protein HET PF06985.11 CCF38492.1 - 1.3e-29 103.4 0.0 4.4e-29 101.7 0.0 1.9 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Aconitase PF00330.20 CCF38493.1 - 1.7e-100 337.2 0.2 1.3e-95 321.2 0.2 2.9 1 1 1 2 2 2 2 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 CCF38493.1 - 3.3e-22 79.2 0.0 6.4e-22 78.3 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain NAD_binding_10 PF13460.6 CCF38494.1 - 1.9e-22 80.1 0.7 2.4e-22 79.7 0.7 1.1 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CCF38494.1 - 8e-06 25.5 0.0 1.3e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CCF38494.1 - 0.00013 21.5 0.0 0.00045 19.7 0.0 1.7 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 CCF38494.1 - 0.0072 15.5 1.5 0.021 13.9 0.0 2.2 2 1 0 2 2 2 1 RmlD substrate binding domain 2OG-FeII_Oxy PF03171.20 CCF38495.1 - 1.7e-05 25.3 0.0 3e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 CCF38495.1 - 9.8e-05 23.1 0.0 0.00063 20.5 0.0 2.2 2 0 0 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal PIGA PF08288.12 CCF38496.1 - 4.1e-45 152.3 3.0 9.3e-45 151.1 0.9 2.3 2 0 0 2 2 2 1 PIGA (GPI anchor biosynthesis) Glyco_transf_4 PF13439.6 CCF38496.1 - 3.3e-30 105.3 0.5 5.1e-30 104.7 0.5 1.3 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glycos_transf_1 PF00534.20 CCF38496.1 - 2.9e-27 95.3 0.0 4.2e-27 94.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 CCF38496.1 - 8.6e-23 81.3 0.1 1.9e-22 80.1 0.1 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 CCF38496.1 - 3.9e-12 46.9 0.0 7e-12 46.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_4_2 PF13477.6 CCF38496.1 - 6.2e-06 26.3 0.1 1.2e-05 25.4 0.1 1.4 1 0 0 1 1 1 1 Glycosyl transferase 4-like Glyco_trans_1_2 PF13524.6 CCF38496.1 - 6.7e-05 23.2 0.0 0.00085 19.7 0.0 2.3 2 0 0 2 2 2 1 Glycosyl transferases group 1 DEAD PF00270.29 CCF38497.1 - 5.4e-32 111.0 0.0 2.3e-16 60.1 0.0 2.4 1 1 0 2 2 2 2 DEAD/DEAH box helicase ResIII PF04851.15 CCF38497.1 - 2.2e-08 34.3 1.9 5.5e-08 33.0 0.0 2.4 2 2 0 2 2 2 1 Type III restriction enzyme, res subunit UvrD-helicase PF00580.21 CCF38497.1 - 0.087 12.3 0.0 0.087 12.3 0.0 2.2 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain ABC2_membrane PF01061.24 CCF38499.1 - 3.2e-21 75.7 24.3 4e-21 75.4 24.3 1.1 1 0 0 1 1 1 1 ABC-2 type transporter ABC2_membrane_3 PF12698.7 CCF38499.1 - 0.00039 19.6 14.7 0.00039 19.6 14.7 1.4 1 1 0 1 1 1 1 ABC-2 family transporter protein PDR_CDR PF06422.12 CCF38499.1 - 0.00061 19.6 1.8 0.00087 19.2 0.1 2.2 2 0 0 2 2 2 1 CDR ABC transporter DNApol_Exo PF18136.1 CCF38500.1 - 8.2e-104 346.7 0.0 1.5e-103 345.9 0.0 1.4 1 0 0 1 1 1 1 DNA mitochondrial polymerase exonuclease domain DNA_pol_A PF00476.20 CCF38500.1 - 4.8e-55 187.1 0.0 8.1e-55 186.4 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase family A Recep_L_domain PF01030.24 CCF38501.1 - 0.0064 16.6 5.8 0.25 11.5 0.1 4.1 1 1 3 4 4 4 1 Receptor L domain P53_C PF11619.8 CCF38501.1 - 0.14 12.2 0.2 1.2 9.3 0.0 2.5 3 0 0 3 3 3 0 Transcription factor P53 - C terminal domain ADH_N PF08240.12 CCF38502.1 - 3.1e-26 91.4 2.3 7.8e-26 90.1 2.3 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCF38502.1 - 1.2e-15 57.7 0.2 2.1e-15 56.9 0.2 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase UDPG_MGDP_dh_N PF03721.14 CCF38502.1 - 0.045 13.3 0.1 0.079 12.5 0.1 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain AlaDh_PNT_C PF01262.21 CCF38502.1 - 0.068 12.5 0.2 0.13 11.6 0.2 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain TrkA_N PF02254.18 CCF38502.1 - 0.17 12.2 0.1 0.17 12.2 0.1 1.6 2 0 0 2 2 2 0 TrkA-N domain CENP-N PF05238.13 CCF38504.1 - 2.5e-136 455.3 0.0 2.9e-136 455.1 0.0 1.0 1 0 0 1 1 1 1 Kinetochore protein CHL4 like TatD_DNase PF01026.21 CCF38505.1 - 1.3e-48 165.7 0.0 2.1e-48 164.9 0.0 1.4 1 1 0 1 1 1 1 TatD related DNase PAC4 PF16093.5 CCF38506.1 - 1.3e-22 79.8 0.1 1.7e-22 79.4 0.1 1.2 1 0 0 1 1 1 1 Proteasome assembly chaperone 4 IBN_N PF03810.19 CCF38507.1 - 0.0015 18.4 0.2 0.019 14.9 0.2 2.3 1 1 0 1 1 1 1 Importin-beta N-terminal domain MRFAP1 PF15155.6 CCF38508.1 - 0.0018 18.8 0.6 0.003 18.1 0.6 1.4 1 1 0 1 1 1 1 MORF4 family-associated protein1 SesA PF17107.5 CCF38508.1 - 0.0026 18.0 0.3 0.0031 17.7 0.3 1.2 1 0 0 1 1 1 1 N-terminal domain on NACHT_NTPase and P-loop NTPases CENP-Q PF13094.6 CCF38508.1 - 0.011 16.0 2.7 0.02 15.1 2.6 1.4 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Helo_like_N PF17111.5 CCF38508.1 - 0.022 14.1 0.2 0.029 13.7 0.2 1.3 1 0 0 1 1 1 0 Fungal N-terminal domain of STAND proteins Rab5-bind PF09311.11 CCF38508.1 - 0.026 13.9 2.7 0.22 10.9 3.4 1.8 1 1 1 2 2 2 0 Rabaptin-like protein GvpL_GvpF PF06386.11 CCF38508.1 - 0.047 13.6 2.2 0.058 13.3 2.2 1.1 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF CorA PF01544.18 CCF38508.1 - 0.062 12.6 2.9 0.069 12.4 2.9 1.1 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein PKcGMP_CC PF16808.5 CCF38508.1 - 0.079 12.8 1.2 0.079 12.8 1.2 2.6 3 0 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase V-SNARE PF05008.15 CCF38508.1 - 0.2 12.1 3.0 0.39 11.1 0.7 2.3 2 1 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus Latarcin PF10279.9 CCF38508.1 - 0.25 11.8 5.9 0.35 11.3 0.3 2.4 1 1 1 2 2 2 0 Latarcin precursor p450 PF00067.22 CCF38509.1 - 5.8e-44 150.6 0.0 7.6e-44 150.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Peptidase_S15 PF02129.18 CCF38510.1 - 2.5e-35 122.4 0.5 3.1e-35 122.1 0.5 1.1 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Hydrolase_4 PF12146.8 CCF38510.1 - 0.0034 16.7 0.0 0.0089 15.3 0.0 1.7 1 1 0 1 1 1 1 Serine aminopeptidase, S33 PepX_C PF08530.10 CCF38510.1 - 0.014 15.3 2.1 0.058 13.3 0.2 2.6 2 1 0 2 2 2 0 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain FAD_binding_3 PF01494.19 CCF38511.1 - 0.00051 19.4 0.2 0.0015 17.9 0.2 1.6 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 CCF38511.1 - 0.0066 16.7 1.0 0.016 15.4 1.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CCF38511.1 - 0.055 12.7 0.2 0.088 12.0 0.2 1.4 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCF38511.1 - 0.095 12.3 1.5 0.17 11.4 1.5 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase Trp_halogenase PF04820.14 CCF38511.1 - 0.14 11.0 1.5 10 4.8 1.8 2.1 2 0 0 2 2 2 0 Tryptophan halogenase AlaDh_PNT_C PF01262.21 CCF38511.1 - 0.2 10.9 1.0 0.33 10.2 1.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_2 PF00890.24 CCF38511.1 - 0.63 9.0 4.0 1.4 7.9 3.8 1.6 2 0 0 2 2 2 0 FAD binding domain FMN_dh PF01070.18 CCF38512.1 - 6.4e-119 397.0 0.1 7.6e-119 396.8 0.1 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Glu_synthase PF01645.17 CCF38512.1 - 2.9e-07 29.9 0.0 5.1e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 CCF38512.1 - 8.1e-05 21.8 1.4 0.00072 18.7 0.1 2.4 3 0 0 3 3 3 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.15 CCF38512.1 - 0.0012 18.3 0.3 0.0023 17.4 0.3 1.4 1 0 0 1 1 1 1 Nitronate monooxygenase His_biosynth PF00977.21 CCF38512.1 - 0.0086 15.6 1.3 0.42 10.0 0.1 2.3 1 1 0 2 2 2 1 Histidine biosynthesis protein G3P_antiterm PF04309.12 CCF38512.1 - 0.029 13.8 0.1 0.32 10.4 0.0 2.1 2 0 0 2 2 2 0 Glycerol-3-phosphate responsive antiterminator ThiG PF05690.14 CCF38512.1 - 0.041 13.2 0.2 6.3 6.0 0.1 2.2 2 0 0 2 2 2 0 Thiazole biosynthesis protein ThiG DUF561 PF04481.12 CCF38512.1 - 0.13 11.4 0.2 1.2 8.2 0.0 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF561) DUF1929 PF09118.11 CCF38514.1 - 2e-23 82.5 0.0 5.7e-23 81.0 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1929) Kelch_6 PF13964.6 CCF38514.1 - 5e-14 52.0 0.0 0.0042 17.3 0.0 4.1 3 0 0 3 3 3 3 Kelch motif PAN_1 PF00024.26 CCF38514.1 - 3.8e-13 49.2 5.8 1.1e-06 28.5 1.1 2.4 2 0 0 2 2 2 2 PAN domain Kelch_1 PF01344.25 CCF38514.1 - 9e-13 47.6 0.3 0.00027 20.4 0.2 4.1 3 1 0 3 3 3 3 Kelch motif Kelch_4 PF13418.6 CCF38514.1 - 4.8e-10 39.3 6.8 0.0016 18.4 0.0 6.0 6 1 0 6 6 6 2 Galactose oxidase, central domain Kelch_2 PF07646.15 CCF38514.1 - 4.5e-09 35.9 0.0 0.026 14.5 0.0 4.9 4 1 0 4 4 4 2 Kelch motif Glyoxal_oxid_N PF07250.11 CCF38514.1 - 1.9e-06 27.2 0.0 0.11 11.7 0.1 3.0 2 1 0 2 2 2 2 Glyoxal oxidase N-terminus PAN_4 PF14295.6 CCF38514.1 - 4.2e-05 23.4 8.0 0.039 13.9 0.8 2.6 2 0 0 2 2 2 2 PAN domain Kelch_3 PF13415.6 CCF38514.1 - 0.037 14.3 0.0 4 7.8 0.0 3.5 3 0 0 3 3 3 0 Galactose oxidase, central domain MANEC PF07502.14 CCF38514.1 - 0.043 14.1 7.5 1.1 9.6 0.4 2.4 2 0 0 2 2 2 0 MANEC domain Ras PF00071.22 CCF38515.1 - 7.2e-40 136.2 0.0 1.4e-37 128.8 0.0 2.1 2 0 0 2 2 2 2 Ras family Roc PF08477.13 CCF38515.1 - 1.8e-31 108.8 0.0 2.7e-31 108.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCF38515.1 - 4.7e-11 42.5 0.0 7.5e-11 41.8 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 CCF38515.1 - 1.6e-05 24.9 0.0 2.9e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 CCF38515.1 - 0.0061 16.0 0.0 0.0089 15.5 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit RTP1_C2 PF10304.9 CCF38515.1 - 0.023 14.4 0.6 0.042 13.6 0.6 1.4 1 0 0 1 1 1 0 Required for nuclear transport of RNA pol II C-terminus 2 Herpes_TAF50 PF03326.13 CCF38515.1 - 0.027 13.1 0.3 0.036 12.7 0.3 1.1 1 0 0 1 1 1 0 Herpesvirus transcription activation factor (transactivator) Gtr1_RagA PF04670.12 CCF38515.1 - 0.21 10.9 0.0 0.33 10.3 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Sec63 PF02889.16 CCF38516.1 - 3.6e-53 180.4 0.0 4.7e-53 180.0 0.0 1.2 1 0 0 1 1 1 1 Sec63 Brl domain Helicase_C PF00271.31 CCF38516.1 - 6e-08 33.0 0.0 5.8e-07 29.8 0.0 2.6 2 1 0 2 2 2 1 Helicase conserved C-terminal domain Fungal_trans PF04082.18 CCF38518.1 - 3e-26 92.1 0.1 4e-26 91.6 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF38518.1 - 4e-11 42.9 8.3 6.8e-11 42.1 8.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Mito_carr PF00153.27 CCF38519.1 - 6.7e-53 176.6 5.6 3.3e-18 65.4 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein MFS_1 PF07690.16 CCF38520.1 - 7.3e-35 120.5 25.3 1e-34 120.0 25.3 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 CCF38520.1 - 7.9e-07 28.7 5.1 1.6e-06 27.7 5.1 1.4 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB Peptidase_M1 PF01433.20 CCF38520.1 - 0.11 12.1 0.1 0.29 10.7 0.1 1.7 1 1 0 1 1 1 0 Peptidase family M1 domain HET PF06985.11 CCF38521.1 - 6.9e-10 39.5 4.0 7.8e-08 32.8 0.1 2.5 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) Zn_clus PF00172.18 CCF38522.1 - 5.9e-07 29.5 13.3 1.1e-06 28.6 13.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain GFO_IDH_MocA PF01408.22 CCF38523.1 - 7.8e-14 52.5 0.0 1.4e-13 51.7 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_3 PF03447.16 CCF38523.1 - 0.021 15.5 0.2 0.044 14.5 0.2 1.5 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain GATase PF00117.28 CCF38524.1 - 0.084 12.6 0.0 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 Glutamine amidotransferase class-I Nucleopor_Nup85 PF07575.13 CCF38526.1 - 2.7e-17 62.6 0.0 3e-11 42.6 0.0 2.8 2 1 0 2 2 2 2 Nup85 Nucleoporin Annexin PF00191.20 CCF38527.1 - 5.5e-70 231.4 6.2 9.1e-20 70.5 0.0 4.4 4 1 0 4 4 4 4 Annexin DUF3574 PF12098.8 CCF38527.1 - 0.00094 18.9 0.7 4 7.3 0.0 3.7 4 0 0 4 4 4 1 Protein of unknown function (DUF3574) Acetyltransf_11 PF13720.6 CCF38527.1 - 0.022 15.2 2.5 33 5.0 0.0 3.8 4 0 0 4 4 4 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 Myb_DNA-bind_7 PF15963.5 CCF38527.1 - 0.086 12.7 0.2 1.8 8.5 0.1 2.5 2 0 0 2 2 2 0 Myb DNA-binding like Minor_tail_Z PF06763.11 CCF38527.1 - 0.17 11.6 0.2 2.8 7.7 0.1 2.3 2 0 0 2 2 2 0 Prophage minor tail protein Z (GPZ) DUF2255 PF10012.9 CCF38527.1 - 0.29 11.3 2.0 13 5.9 0.0 3.5 4 1 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2255) YlbE PF14003.6 CCF38527.1 - 0.35 11.3 1.7 30 5.2 0.0 3.1 3 0 0 3 3 3 0 YlbE-like protein NUDIX PF00293.28 CCF38528.1 - 3.5e-18 65.9 0.1 4.5e-18 65.6 0.1 1.1 1 0 0 1 1 1 1 NUDIX domain SPX PF03105.19 CCF38529.1 - 6.3e-40 138.3 0.7 8.8e-40 137.8 0.7 1.2 1 0 0 1 1 1 1 SPX domain zf-C3HC4 PF00097.25 CCF38529.1 - 1.9e-08 34.0 10.4 3.4e-08 33.2 10.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CCF38529.1 - 6.8e-08 32.2 9.2 1.3e-07 31.3 9.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 CCF38529.1 - 1.1e-07 31.8 8.6 2.2e-07 30.9 8.6 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 CCF38529.1 - 1.6e-07 31.1 9.4 2.7e-07 30.3 9.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CCF38529.1 - 5.2e-06 26.7 11.7 1.1e-05 25.6 11.7 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 CCF38529.1 - 7.9e-05 22.6 7.5 0.00017 21.5 7.5 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 CCF38529.1 - 0.00014 21.8 9.8 0.00035 20.5 9.8 1.7 1 1 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 CCF38529.1 - 0.022 14.6 10.5 0.12 12.2 10.9 2.0 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 CCF38529.1 - 0.029 14.2 5.6 0.029 14.2 5.6 1.9 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.7 CCF38529.1 - 0.042 14.1 9.5 0.12 12.7 9.5 1.7 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 CCF38529.1 - 0.081 13.0 2.6 0.17 12.0 2.6 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger FoP_duplication PF13865.6 CCF38529.1 - 0.1 13.2 0.1 0.19 12.3 0.1 1.4 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 TerY_C PF15616.6 CCF38529.1 - 0.11 12.6 1.2 0.19 11.8 1.2 1.5 1 0 0 1 1 1 0 TerY-C metal binding domain zf-RING_6 PF14835.6 CCF38529.1 - 0.11 12.4 2.8 0.26 11.2 2.8 1.6 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_10 PF16685.5 CCF38529.1 - 0.33 11.1 5.4 0.72 10.0 5.4 1.6 1 1 0 1 1 1 0 zinc RING finger of MSL2 Cys_Met_Meta_PP PF01053.20 CCF38530.1 - 6.6e-35 120.4 0.0 9.2e-35 119.9 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 CCF38530.1 - 0.049 12.8 0.0 0.08 12.1 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class I and II Bestrophin PF01062.21 CCF38532.1 - 5.3e-38 131.1 0.3 9.6e-38 130.2 0.3 1.3 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel DUF4720 PF15846.5 CCF38533.1 - 0.91 9.4 3.0 1.1 9.1 0.1 2.6 4 0 0 4 4 4 0 Domain of unknown function (DUF4720) p450 PF00067.22 CCF38534.1 - 1.4e-39 136.2 0.0 2e-39 135.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Aldedh PF00171.22 CCF38535.1 - 8e-154 512.5 0.0 9e-154 512.4 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family PTR2 PF00854.21 CCF38536.1 - 7.9e-55 186.3 4.1 7.9e-55 186.3 4.1 1.8 1 1 1 2 2 2 1 POT family AZUL PF16558.5 CCF38538.1 - 1.8e-22 79.3 2.3 4.7e-22 78.0 2.3 1.7 1 0 0 1 1 1 1 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A Nse5 PF08691.10 CCF38541.1 - 0.26 9.9 0.0 0.32 9.6 0.0 1.0 1 0 0 1 1 1 0 DNA repair proteins Nse5 and Nse6 OPT PF03169.15 CCF38542.1 - 1.1e-67 229.1 20.6 2.3e-67 228.1 20.6 1.4 1 1 0 1 1 1 1 OPT oligopeptide transporter protein DUF3328 PF11807.8 CCF38543.1 - 1.6e-52 178.5 1.5 2e-52 178.2 1.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Ssu72 PF04722.13 CCF38544.1 - 1.8e-83 278.8 0.0 2.1e-83 278.6 0.0 1.0 1 0 0 1 1 1 1 Ssu72-like protein zf-C2H2 PF00096.26 CCF38546.1 - 4.2e-10 39.5 16.6 4.5e-05 23.7 4.2 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 CCF38546.1 - 5.4e-07 29.4 12.0 0.00052 19.9 1.3 2.4 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CCF38546.1 - 3.7e-06 27.1 3.1 0.032 14.5 1.0 2.6 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 CCF38546.1 - 5.5e-06 26.8 13.9 0.016 16.0 3.6 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 CCF38546.1 - 3.6e-05 24.0 12.1 0.00032 21.0 3.2 3.4 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_11 PF16622.5 CCF38546.1 - 0.042 13.6 11.2 0.27 11.0 1.2 2.3 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-C2HC_2 PF13913.6 CCF38546.1 - 0.048 13.6 8.5 0.2 11.6 0.6 2.4 2 0 0 2 2 2 0 zinc-finger of a C2HC-type DUF2256 PF10013.9 CCF38546.1 - 0.051 13.7 2.1 8.3 6.6 0.3 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-met PF12874.7 CCF38546.1 - 0.24 11.9 9.5 1.3 9.5 1.3 2.8 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 CCF38546.1 - 0.3 11.5 7.0 4.6 7.6 0.8 2.2 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-Dof PF02701.15 CCF38546.1 - 0.72 10.0 5.2 4 7.6 5.4 1.9 1 1 1 2 2 2 0 Dof domain, zinc finger DUF1773 PF08593.10 CCF38547.1 - 0.16 13.0 0.0 0.27 12.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function Folliculin PF11704.8 CCF38548.1 - 2.2e-60 203.7 0.3 9.8e-60 201.6 0.0 2.1 2 1 0 2 2 2 1 Vesicle coat protein involved in Golgi to plasma membrane transport DOPA_dioxygen PF08883.11 CCF38551.1 - 4.5e-44 149.0 0.2 9.1e-44 148.0 0.2 1.5 1 1 0 1 1 1 1 Dopa 4,5-dioxygenase family BHD_3 PF10405.9 CCF38552.1 - 2.5e-26 91.9 0.2 4.4e-26 91.1 0.2 1.4 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BHD_1 PF10403.9 CCF38552.1 - 3.8e-22 77.9 0.0 8.7e-22 76.7 0.0 1.7 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 BHD_2 PF10404.9 CCF38552.1 - 7.2e-17 62.1 0.3 7.2e-17 62.1 0.3 3.5 2 1 0 2 2 2 1 Rad4 beta-hairpin domain 2 Rad4 PF03835.15 CCF38552.1 - 0.014 15.1 6.2 0.23 11.1 0.2 2.7 2 1 1 3 3 3 0 Rad4 transglutaminase-like domain Transglut_core PF01841.19 CCF38552.1 - 0.056 13.9 0.0 0.19 12.2 0.0 1.9 2 0 0 2 2 2 0 Transglutaminase-like superfamily Nop14 PF04147.12 CCF38552.1 - 2.1 6.5 10.5 3.1 5.9 10.5 1.1 1 0 0 1 1 1 0 Nop14-like family DUF4611 PF15387.6 CCF38552.1 - 3.2 8.0 8.1 87 3.4 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) AZUL PF16558.5 CCF38553.1 - 2.7e-07 30.7 0.9 7.1e-07 29.4 0.0 2.0 2 0 0 2 2 2 1 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A GDP_Man_Dehyd PF16363.5 CCF38555.1 - 1.1e-07 31.6 0.0 1.1e-07 31.6 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 CCF38555.1 - 2.3e-07 30.5 0.1 2.3e-07 30.5 0.1 1.0 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CCF38555.1 - 0.00015 20.9 0.1 0.00015 20.9 0.1 1.0 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short PF00106.25 CCF38555.1 - 0.00035 20.1 0.0 0.00035 20.1 0.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase NAD_binding_4 PF07993.12 CCF38555.1 - 0.0017 17.6 0.1 0.0017 17.6 0.1 1.1 1 0 0 1 1 1 1 Male sterility protein RmlD_sub_bind PF04321.17 CCF38555.1 - 0.0068 15.5 0.0 0.0068 15.5 0.0 1.0 1 0 0 1 1 1 1 RmlD substrate binding domain NmrA PF05368.13 CCF38555.1 - 0.0085 15.7 0.1 0.0085 15.7 0.1 1.1 1 0 0 1 1 1 1 NmrA-like family KR PF08659.10 CCF38555.1 - 0.019 14.9 0.1 0.019 14.9 0.1 1.1 1 0 0 1 1 1 0 KR domain NAD_binding_10 PF13460.6 CCF38555.1 - 0.065 13.1 0.0 0.065 13.1 0.0 1.1 1 0 0 1 1 1 0 NAD(P)H-binding Amdase PF17645.1 CCF38555.1 - 0.12 11.9 0.0 0.13 11.8 0.0 1.0 1 0 0 1 1 1 0 Arylmalonate decarboxylase UDPG_MGDP_dh_N PF03721.14 CCF38555.1 - 0.14 11.7 0.1 0.14 11.7 0.1 1.1 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 3HCDH_N PF02737.18 CCF38555.1 - 0.18 11.7 0.1 0.18 11.7 0.1 1.1 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 CCF38556.1 - 1.2e-47 161.9 0.0 1.8e-47 161.3 0.0 1.2 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh PF00984.19 CCF38556.1 - 1.8e-26 92.2 0.0 3.4e-26 91.3 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_C PF03720.15 CCF38556.1 - 4.5e-20 72.0 0.0 1.3e-17 64.1 0.0 2.7 3 0 0 3 3 3 2 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain Peptidase_S8 PF00082.22 CCF38557.1 - 1.1e-13 51.1 0.0 1.6e-13 50.6 0.0 1.1 1 0 0 1 1 1 1 Subtilase family MFS_1 PF07690.16 CCF38558.1 - 2.9e-25 88.9 27.7 5.6e-25 88.0 27.4 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily OTT_1508_deam PF14441.6 CCF38559.1 - 1.3e-15 57.1 2.9 4.5e-15 55.4 2.9 2.0 1 0 0 1 1 1 1 OTT_1508-like deaminase Pectinesterase PF01095.19 CCF38560.1 - 1.1e-49 168.8 8.4 1.3e-49 168.5 8.4 1.0 1 0 0 1 1 1 1 Pectinesterase DLL_N PF12413.8 CCF38560.1 - 0.21 12.8 7.9 0.84 10.9 0.3 3.2 3 1 0 3 3 3 0 Homeobox protein distal-less-like N terminal Cation_ATPase_C PF00689.21 CCF38563.1 - 9.3e-30 103.7 5.3 9.3e-30 103.7 5.3 2.0 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 CCF38563.1 - 5.1e-24 84.8 13.7 2.3e-17 63.1 0.3 3.4 4 0 0 4 4 4 2 E1-E2 ATPase Hydrolase PF00702.26 CCF38563.1 - 6.1e-21 75.7 0.2 1.3e-16 61.6 0.2 3.0 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CCF38563.1 - 5.8e-20 71.2 0.0 1.3e-19 70.1 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 CCF38563.1 - 2.6e-06 27.4 2.0 0.00018 21.3 0.6 2.6 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase cwf18 PF08315.12 CCF38566.1 - 3.7e-45 153.9 6.3 3.7e-45 153.9 6.3 1.6 2 0 0 2 2 2 1 cwf18 pre-mRNA splicing factor Pam16 PF03656.13 CCF38566.1 - 0.13 12.3 3.3 0.15 12.0 1.6 1.9 1 1 1 2 2 2 0 Pam16 PPR_2 PF13041.6 CCF38568.1 - 2.8e-08 33.8 0.0 5.6e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 PPR repeat family PPR PF01535.20 CCF38568.1 - 7.5e-06 25.9 0.0 1.6e-05 24.9 0.0 1.6 1 0 0 1 1 1 1 PPR repeat PPR_1 PF12854.7 CCF38568.1 - 6.5e-05 22.6 0.0 0.00024 20.7 0.0 2.0 3 0 0 3 3 3 1 PPR repeat PPR_3 PF13812.6 CCF38568.1 - 0.00011 22.2 0.0 0.00018 21.5 0.0 1.4 1 0 0 1 1 1 1 Pentatricopeptide repeat domain PPR_long PF17177.4 CCF38568.1 - 0.041 13.3 0.0 0.048 13.0 0.0 1.1 1 0 0 1 1 1 0 Pentacotripeptide-repeat region of PRORP NatB_MDM20 PF09797.9 CCF38569.1 - 1.8e-50 172.0 0.0 2.9e-50 171.3 0.0 1.3 1 0 0 1 1 1 1 N-acetyltransferase B complex (NatB) non catalytic subunit zf-C4pol PF14260.6 CCF38569.1 - 0.3 11.6 8.0 0.57 10.7 0.6 3.4 3 0 0 3 3 3 0 C4-type zinc-finger of DNA polymerase delta Ilm1 PF10311.9 CCF38570.1 - 1.2e-66 223.5 0.3 1.3e-66 223.3 0.3 1.0 1 0 0 1 1 1 1 Increased loss of mitochondrial DNA protein 1 DPBB_1 PF03330.18 CCF38573.1 - 3e-08 33.8 0.0 1.3e-07 31.7 0.0 2.0 2 0 0 2 2 2 1 Lytic transglycolase Barwin PF00967.17 CCF38573.1 - 5.8e-05 22.9 0.2 0.00011 22.1 0.2 1.4 1 0 0 1 1 1 1 Barwin family TMEM154 PF15102.6 CCF38573.1 - 0.078 12.9 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 TMEM154 protein family Hpt PF01627.23 CCF38574.1 - 1.6e-13 50.7 0.1 2.3e-13 50.2 0.1 1.3 1 0 0 1 1 1 1 Hpt domain NusB PF01029.18 CCF38574.1 - 0.055 13.7 0.1 0.25 11.6 0.0 1.8 2 0 0 2 2 2 0 NusB family AKAP7_NLS PF10469.9 CCF38576.1 - 1e-30 107.2 0.0 1.2e-30 107.0 0.0 1.1 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain Tmemb_cc2 PF10267.9 CCF38577.1 - 0.36 9.9 4.3 0.42 9.7 4.3 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein SRC-1 PF08832.10 CCF38577.1 - 2.4 9.3 10.8 2.3 9.3 2.0 2.3 2 0 0 2 2 2 0 Steroid receptor coactivator Gti1_Pac2 PF09729.9 CCF38578.1 - 7.7e-61 205.3 0.0 1.3e-60 204.6 0.0 1.4 1 0 0 1 1 1 1 Gti1/Pac2 family CDP-OH_P_transf PF01066.21 CCF38579.1 - 1.9e-15 57.4 0.3 1.9e-15 57.4 0.3 2.5 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Comm PF15957.5 CCF38580.1 - 1.7 9.0 3.7 4.7 7.6 1.6 2.4 2 0 0 2 2 2 0 Commissureless DUF805 PF05656.14 CCF38580.1 - 5.2 7.5 13.6 16 6.0 13.4 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF805) Abhydrolase_6 PF12697.7 CCF38581.1 - 3e-10 41.1 0.0 3.6e-09 37.5 0.0 2.2 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCF38581.1 - 0.00041 19.7 0.0 0.045 13.0 0.0 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Lipase_3 PF01764.25 CCF38581.1 - 0.18 11.7 0.1 0.84 9.5 0.1 1.8 1 1 0 2 2 2 0 Lipase (class 3) MFS_1 PF07690.16 CCF38583.1 - 6.9e-06 25.2 4.9 9.1e-06 24.8 4.9 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF38583.1 - 0.00047 19.2 0.0 0.00053 19.0 0.0 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter EI24 PF07264.11 CCF38583.1 - 0.048 13.9 1.3 0.061 13.6 1.3 1.1 1 0 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) SWI-SNF_Ssr4 PF08549.10 CCF38585.1 - 3.4e-96 323.5 3.1 4.1e-96 323.3 3.1 1.0 1 0 0 1 1 1 1 Fungal domain of unknown function (DUF1750) 6PGD PF00393.19 CCF38586.1 - 5.4e-128 426.4 0.0 7.6e-128 425.9 0.0 1.2 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 CCF38586.1 - 4.6e-49 166.6 0.0 7.7e-49 165.9 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase DNA_pol3_beta PF00712.19 CCF38586.1 - 0.018 15.2 0.1 0.045 13.9 0.1 1.6 1 0 0 1 1 1 0 DNA polymerase III beta subunit, N-terminal domain PGK PF00162.19 CCF38586.1 - 0.037 13.0 0.0 0.074 12.0 0.0 1.5 1 0 0 1 1 1 0 Phosphoglycerate kinase NAD_binding_11 PF14833.6 CCF38586.1 - 0.12 12.6 0.1 0.66 10.2 0.0 2.3 2 0 0 2 2 2 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase ANT PF03374.14 CCF38586.1 - 0.17 12.2 0.0 4.4 7.7 0.0 2.4 2 0 0 2 2 2 0 Phage antirepressor protein KilAC domain RRM_1 PF00076.22 CCF38587.1 - 4.1e-17 61.8 0.0 7.5e-17 60.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Cytotoxic PF09000.10 CCF38587.1 - 0.022 15.1 0.0 0.06 13.7 0.0 1.8 1 0 0 1 1 1 0 Cytotoxic OB_RNB PF08206.11 CCF38587.1 - 0.14 11.8 0.2 0.28 10.9 0.2 1.4 1 0 0 1 1 1 0 Ribonuclease B OB domain TPT PF03151.16 CCF38588.1 - 6.9e-20 71.6 13.9 8.9e-20 71.2 13.9 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 CCF38588.1 - 2.3e-05 24.6 34.8 0.0027 17.9 7.3 2.5 2 1 0 2 2 2 2 EamA-like transporter family PI3K_1B_p101 PF10486.9 CCF38588.1 - 0.093 10.5 6.2 0.14 9.9 6.2 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit PUNUT PF16913.5 CCF38588.1 - 0.11 11.7 14.8 0.42 9.8 14.2 2.0 1 1 0 1 1 1 0 Purine nucleobase transmembrane transport DNase_NucA_NucB PF14040.6 CCF38589.1 - 0.066 13.6 0.0 0.073 13.5 0.0 1.0 1 0 0 1 1 1 0 Deoxyribonuclease NucA/NucB Slx4 PF09494.10 CCF38590.1 - 3.8e-18 65.2 0.1 4.4e-18 65.0 0.1 1.1 1 0 0 1 1 1 1 Slx4 endonuclease NUDIX PF00293.28 CCF38591.1 - 4.9e-08 33.1 0.0 1.2e-07 31.9 0.0 1.7 1 0 0 1 1 1 1 NUDIX domain Sporozoite_P67 PF05642.11 CCF38592.1 - 0.68 8.0 5.7 1.1 7.3 5.7 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen CDC45 PF02724.14 CCF38592.1 - 5.4 5.2 5.9 7.3 4.8 5.9 1.1 1 0 0 1 1 1 0 CDC45-like protein Cwf_Cwc_15 PF04889.12 CCF38592.1 - 6.5 6.4 11.7 10 5.7 11.7 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Zn_clus PF00172.18 CCF38593.1 - 3.9e-07 30.1 10.3 6e-07 29.5 10.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Aldedh PF00171.22 CCF38595.1 - 3e-121 405.1 3.3 3.7e-121 404.9 3.3 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family SecE PF00584.20 CCF38596.1 - 0.66 10.0 5.7 4.5 7.3 0.0 2.1 2 0 0 2 2 2 0 SecE/Sec61-gamma subunits of protein translocation complex GST_N_2 PF13409.6 CCF38597.1 - 1.5e-07 31.6 0.0 2.6e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 CCF38597.1 - 2.2e-05 24.8 0.0 5.6e-05 23.5 0.0 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CCF38597.1 - 0.00011 22.1 0.5 0.00026 20.9 0.4 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 CCF38597.1 - 0.0091 16.2 0.0 0.014 15.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Sugar_tr PF00083.24 CCF38598.1 - 3.5e-75 253.6 23.7 4.1e-75 253.4 23.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF38598.1 - 8.5e-19 67.7 29.9 8.5e-19 67.7 29.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Fungal_trans PF04082.18 CCF38599.1 - 2.6e-27 95.5 0.1 6e-27 94.3 0.0 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain DEAD PF00270.29 CCF38600.1 - 1.1e-49 168.6 0.0 3e-49 167.2 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF38600.1 - 5.8e-27 94.2 0.0 5.1e-24 84.8 0.0 2.6 2 0 0 2 2 2 2 Helicase conserved C-terminal domain DBP10CT PF08147.12 CCF38600.1 - 2.4e-21 75.7 4.1 2.4e-21 75.7 4.1 2.3 2 0 0 2 2 2 1 DBP10CT (NUC160) domain AP2 PF00847.20 CCF38600.1 - 0.5 10.7 10.6 0.036 14.3 2.7 3.0 2 1 0 2 2 2 0 AP2 domain Sorting_nexin PF03700.13 CCF38600.1 - 0.72 10.4 9.7 0.7 10.5 3.3 2.7 2 1 0 2 2 2 0 Sorting nexin, N-terminal domain HSP70 PF00012.20 CCF38601.1 - 3.7e-11 41.9 0.1 1.5e-08 33.3 0.1 2.0 2 0 0 2 2 2 2 Hsp70 protein Tropomyosin PF00261.20 CCF38602.1 - 0.029 13.8 2.0 0.052 12.9 2.0 1.4 1 0 0 1 1 1 0 Tropomyosin TssN PF17555.2 CCF38603.1 - 0.035 13.5 0.8 2.9 7.2 0.2 2.1 2 0 0 2 2 2 0 Type VI secretion system, TssN Colicin_V PF02674.16 CCF38603.1 - 0.089 12.8 6.9 1.3 9.0 1.9 2.2 2 0 0 2 2 2 0 Colicin V production protein Lipoprotein_18 PF06804.11 CCF38603.1 - 0.24 10.4 0.1 0.52 9.3 0.0 1.5 2 0 0 2 2 2 0 NlpB/DapX lipoprotein 5TM-5TMR_LYT PF07694.12 CCF38603.1 - 0.31 10.5 4.7 1.1 8.8 0.2 2.1 2 0 0 2 2 2 0 5TMR of 5TMR-LYT CUE PF02845.16 CCF38604.1 - 2.1e-05 24.1 0.2 0.016 14.9 0.2 2.7 2 0 0 2 2 2 2 CUE domain Smr PF01713.21 CCF38604.1 - 0.0022 18.3 0.1 0.007 16.7 0.1 1.9 1 0 0 1 1 1 1 Smr domain Pfk_N PF18468.1 CCF38604.1 - 0.12 12.8 0.0 0.28 11.6 0.0 1.5 1 0 0 1 1 1 0 Phosphofructokinase N-terminal domain yeast DUF1771 PF08590.10 CCF38604.1 - 0.15 12.5 8.0 0.29 11.5 8.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1771) FlgM PF04316.13 CCF38604.1 - 0.6 10.5 2.5 14 6.1 0.0 3.5 4 0 0 4 4 4 0 Anti-sigma-28 factor, FlgM Glyco_transf_34 PF05637.12 CCF38605.1 - 6.7e-65 219.1 1.5 1e-64 218.5 1.5 1.3 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family Glyco_hydro_16 PF00722.21 CCF38606.1 - 2.8e-08 33.5 0.0 5.7e-08 32.4 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 SNF2_N PF00176.23 CCF38608.1 - 1.9e-33 115.6 0.0 4.5e-32 111.1 0.0 2.0 2 0 0 2 2 2 2 SNF2 family N-terminal domain DEAD PF00270.29 CCF38608.1 - 7.8e-08 32.3 0.0 1.3e-07 31.6 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 CCF38608.1 - 6.1e-06 26.3 0.0 0.008 16.2 0.0 2.2 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Baculo_LEF5_C PF11792.8 CCF38610.1 - 0.0064 16.1 0.9 0.022 14.4 0.2 2.1 2 0 0 2 2 2 1 Baculoviridae late expression factor 5 C-terminal domain Methyltransf_23 PF13489.6 CCF38611.1 - 0.0014 18.5 0.0 0.0018 18.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain PRP21_like_P PF12230.8 CCF38615.1 - 2.7e-57 194.1 18.1 1.6e-56 191.6 18.1 2.0 1 1 0 1 1 1 1 Pre-mRNA splicing factor PRP21 like protein Surp PF01805.20 CCF38615.1 - 1.4e-40 137.1 4.8 4.5e-21 74.6 0.3 2.6 2 0 0 2 2 2 2 Surp module NinF PF05810.12 CCF38615.1 - 0.0053 16.6 0.1 0.015 15.1 0.1 1.7 1 0 0 1 1 1 1 NinF protein zf_UBZ PF18439.1 CCF38615.1 - 0.0091 15.6 0.4 0.019 14.6 0.4 1.6 1 0 0 1 1 1 1 Ubiquitin-Binding Zinc Finger Ribosomal_60s PF00428.19 CCF38615.1 - 1.4 9.5 15.0 3.1 8.5 0.6 3.6 3 0 0 3 3 3 0 60s Acidic ribosomal protein DUF2920 PF11144.8 CCF38616.1 - 0.078 12.1 0.0 0.089 12.0 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2920) PMT PF02366.18 CCF38617.1 - 1.3e-07 31.4 0.1 1.6e-07 31.2 0.1 1.1 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase CDH-cyt PF16010.5 CCF38618.1 - 3.8e-12 46.2 0.1 4.1e-12 46.1 0.1 1.0 1 0 0 1 1 1 1 Cytochrome domain of cellobiose dehydrogenase Rep_fac-A_C PF08646.10 CCF38620.1 - 4.9e-58 195.0 6.1 3.6e-57 192.2 4.0 2.4 2 0 0 2 2 2 1 Replication factor-A C terminal domain REPA_OB_2 PF16900.5 CCF38620.1 - 1.5e-38 130.6 1.2 3.9e-38 129.3 0.6 2.0 2 0 0 2 2 2 1 Replication protein A OB domain Rep-A_N PF04057.12 CCF38620.1 - 3.5e-24 84.8 0.1 1.1e-23 83.1 0.1 1.9 2 0 0 2 2 2 1 Replication factor-A protein 1, N-terminal domain tRNA_anti-codon PF01336.25 CCF38620.1 - 6e-17 61.4 0.6 1.1e-10 41.3 0.0 4.3 4 1 0 4 4 4 2 OB-fold nucleic acid binding domain CDC24_OB3 PF17244.2 CCF38620.1 - 8.5e-05 22.4 0.9 0.016 15.0 0.2 2.8 3 0 0 3 3 3 2 Cell division control protein 24, OB domain 3 DUF223 PF02721.14 CCF38620.1 - 0.028 14.7 0.0 0.062 13.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function DUF223 DUF4539 PF15072.6 CCF38620.1 - 0.085 12.9 0.1 1.9 8.6 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4539) DUF116 PF01976.17 CCF38620.1 - 0.11 12.0 1.4 0.22 11.0 0.4 2.0 2 0 0 2 2 2 0 Protein of unknown function DUF116 DLH PF01738.18 CCF38621.1 - 6.7e-09 35.6 0.0 2.4e-07 30.6 0.0 2.2 2 0 0 2 2 2 2 Dienelactone hydrolase family Goodbye PF17109.5 CCF38622.1 - 1.5e-31 109.4 0.1 3.8e-31 108.1 0.1 1.8 1 0 0 1 1 1 1 fungal STAND N-terminal Goodbye domain TPR_1 PF00515.28 CCF38622.1 - 1.1e-12 47.1 8.9 9.1e-05 22.1 0.0 4.9 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.17 CCF38622.1 - 3.8e-09 36.0 8.2 0.00015 21.6 0.0 5.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 CCF38622.1 - 1.8e-08 34.6 13.1 0.00077 19.7 0.2 5.3 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 CCF38622.1 - 3.6e-08 32.9 4.7 0.0031 17.4 0.1 4.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 CCF38622.1 - 1.9e-06 27.6 15.9 0.0038 17.3 0.1 6.1 6 0 0 6 6 6 2 Tetratricopeptide repeat AAA_16 PF13191.6 CCF38622.1 - 2.4e-06 28.0 0.0 0.00022 21.7 0.0 3.3 2 1 1 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 CCF38622.1 - 0.00065 20.0 0.0 0.0044 17.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain TPR_14 PF13428.6 CCF38622.1 - 0.00073 20.1 0.3 0.18 12.7 0.0 4.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 CCF38622.1 - 0.001 19.6 5.3 0.003 18.0 0.0 3.5 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 CCF38622.1 - 0.0015 19.2 0.3 0.097 13.3 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.6 CCF38622.1 - 0.0023 17.7 6.2 0.29 11.1 0.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat NACHT PF05729.12 CCF38622.1 - 0.0028 17.6 0.0 0.0082 16.1 0.0 1.9 1 0 0 1 1 1 1 NACHT domain TPR_6 PF13174.6 CCF38622.1 - 0.016 15.8 4.0 8.1 7.3 0.0 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF2075 PF09848.9 CCF38622.1 - 0.018 14.3 0.1 0.061 12.5 0.0 1.9 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) RNA_helicase PF00910.22 CCF38622.1 - 0.15 12.5 0.0 0.84 10.1 0.0 2.4 2 0 0 2 2 1 0 RNA helicase UPF0122 PF04297.14 CCF38622.1 - 2.1 8.6 4.6 27 5.1 0.1 3.8 4 1 0 4 4 3 0 Putative helix-turn-helix protein, YlxM / p13 like FAA_hydrolase PF01557.18 CCF38623.1 - 6.2e-55 186.2 0.0 8.2e-55 185.8 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family B12-binding PF02310.19 CCF38624.1 - 0.027 14.5 0.0 0.042 13.9 0.0 1.3 1 0 0 1 1 1 0 B12 binding domain FtsK_SpoIIIE PF01580.18 CCF38624.1 - 0.11 11.8 0.0 0.13 11.6 0.0 1.1 1 0 0 1 1 1 0 FtsK/SpoIIIE family DXP_reductoisom PF02670.16 CCF38624.1 - 0.14 12.9 0.0 0.17 12.6 0.0 1.2 1 0 0 1 1 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase FAD_binding_3 PF01494.19 CCF38625.1 - 2e-23 83.2 0.0 2.6e-23 82.8 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 CCF38625.1 - 1.2e-13 51.4 2.0 6e-06 26.1 0.0 2.2 1 1 1 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCF38625.1 - 2.3e-08 33.6 0.0 0.00063 19.1 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCF38625.1 - 1.8e-06 28.1 3.3 7.4e-06 26.1 0.9 2.8 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 CCF38625.1 - 2.6e-06 27.9 0.0 0.0017 18.8 0.1 2.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CCF38625.1 - 2.8e-06 26.3 0.3 0.00031 19.6 0.6 2.1 2 0 0 2 2 2 1 HI0933-like protein FAD_binding_2 PF00890.24 CCF38625.1 - 1.3e-05 24.4 1.5 2.9e-05 23.3 1.5 1.5 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 CCF38625.1 - 0.00028 20.4 1.5 0.0004 19.8 1.5 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.22 CCF38625.1 - 0.0011 18.2 0.5 0.0017 17.5 0.5 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A Lycopene_cycl PF05834.12 CCF38625.1 - 0.0037 16.4 0.0 0.0057 15.8 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Thi4 PF01946.17 CCF38625.1 - 0.0087 15.3 0.1 0.014 14.6 0.1 1.2 1 0 0 1 1 1 1 Thi4 family Amino_oxidase PF01593.24 CCF38625.1 - 0.0093 15.3 0.6 1 8.5 0.0 2.8 3 0 0 3 3 3 1 Flavin containing amine oxidoreductase Trp_halogenase PF04820.14 CCF38625.1 - 0.014 14.3 0.5 0.064 12.1 0.1 1.9 1 1 1 2 2 2 0 Tryptophan halogenase 3HCDH_N PF02737.18 CCF38625.1 - 0.033 14.1 0.2 0.056 13.3 0.2 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain SE PF08491.10 CCF38625.1 - 0.08 12.0 0.0 0.21 10.6 0.0 1.7 1 1 0 1 1 1 0 Squalene epoxidase AlaDh_PNT_C PF01262.21 CCF38625.1 - 0.15 11.4 0.2 0.27 10.5 0.2 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_3 PF13738.6 CCF38625.1 - 0.23 10.7 0.0 0.57 9.4 0.0 1.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase MCRA PF06100.11 CCF38625.1 - 0.24 10.2 0.1 15 4.3 0.1 2.1 2 0 0 2 2 2 0 MCRA family LON_substr_bdg PF02190.16 CCF38627.1 - 1.3e-27 97.1 0.0 1.9e-27 96.5 0.0 1.3 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain zf-C3HC4_2 PF13923.6 CCF38627.1 - 2e-13 49.9 19.3 6.8e-12 45.0 9.7 2.7 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 CCF38627.1 - 2.7e-11 43.4 18.8 3.3e-06 27.2 7.8 2.7 2 1 0 2 2 2 2 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 CCF38627.1 - 3.9e-10 39.6 21.6 1.9e-08 34.2 4.9 3.3 2 1 1 3 3 3 2 RING-type zinc-finger zf-C3HC4_3 PF13920.6 CCF38627.1 - 2.8e-09 36.7 18.7 8.5e-08 31.9 6.5 2.4 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CCF38627.1 - 1.6e-08 34.4 22.0 5.9e-06 26.1 9.1 2.5 2 0 0 2 2 2 2 zinc-RING finger domain zf-C3HC4 PF00097.25 CCF38627.1 - 2.3e-08 33.8 18.3 1.8e-06 27.7 9.1 2.5 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CCF38627.1 - 3e-08 33.8 23.5 1.3e-07 31.8 9.9 2.8 2 0 0 2 2 2 2 Ring finger domain Prok-RING_4 PF14447.6 CCF38627.1 - 4e-06 26.6 17.0 0.00012 21.9 7.5 2.5 2 0 0 2 2 2 2 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 CCF38627.1 - 0.00059 19.6 2.5 0.00059 19.6 2.5 2.9 2 1 0 2 2 2 1 RING/Ubox like zinc-binding domain zf-RING_10 PF16685.5 CCF38627.1 - 0.0032 17.6 6.4 0.0032 17.6 6.4 2.5 2 0 0 2 2 2 1 zinc RING finger of MSL2 zf-P11 PF03854.14 CCF38627.1 - 0.0044 16.7 5.9 0.0044 16.7 5.9 2.3 2 1 0 2 2 1 1 P-11 zinc finger zf-rbx1 PF12678.7 CCF38627.1 - 0.0051 17.1 5.3 0.0051 17.1 5.3 2.1 2 0 0 2 2 1 1 RING-H2 zinc finger domain U-box PF04564.15 CCF38627.1 - 0.01 16.0 0.0 0.11 12.6 0.0 2.4 2 0 0 2 2 2 0 U-box domain zinc_ribbon_2 PF13240.6 CCF38627.1 - 2 8.2 4.8 1.4 8.7 0.2 3.1 2 1 0 2 2 2 0 zinc-ribbon domain DZR PF12773.7 CCF38627.1 - 5.1 7.2 12.6 0.77 9.8 1.1 2.9 2 1 1 3 3 3 0 Double zinc ribbon Med2 PF11214.8 CCF38629.1 - 0.0059 16.7 0.3 0.014 15.5 0.1 1.7 2 0 0 2 2 2 1 Mediator complex subunit 2 Syntaxin-6_N PF09177.11 CCF38629.1 - 0.085 13.4 0.4 0.15 12.6 0.4 1.3 1 0 0 1 1 1 0 Syntaxin 6, N-terminal Rad60-SLD PF11976.8 CCF38631.1 - 7.9e-21 73.7 0.1 2e-20 72.4 0.1 1.7 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 CCF38631.1 - 6.5e-07 29.0 0.0 2.3e-06 27.3 0.0 1.8 2 0 0 2 2 2 1 Ubiquitin family TmoB PF06234.12 CCF38631.1 - 0.0089 16.1 0.0 0.017 15.2 0.0 1.4 1 0 0 1 1 1 1 Toluene-4-monooxygenase system protein B (TmoB) LSM PF01423.22 CCF38632.1 - 2.3e-21 75.3 0.0 2.6e-21 75.1 0.0 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 CCF38632.1 - 6.7e-05 23.0 0.0 8.2e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM14 PF12701.7 CCF38632.1 - 0.0013 18.8 0.1 0.0015 18.6 0.1 1.2 1 0 0 1 1 1 1 Scd6-like Sm domain Hfq PF17209.3 CCF38632.1 - 0.11 12.2 0.1 0.14 11.8 0.1 1.2 1 0 0 1 1 1 0 Hfq protein Abhydrolase_1 PF00561.20 CCF38634.1 - 2.3e-19 70.1 0.2 4.3e-16 59.3 0.2 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CCF38634.1 - 1.9e-14 53.5 0.1 7.2e-14 51.6 0.1 1.7 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CCF38634.1 - 4.1e-08 34.1 0.0 5.1e-08 33.8 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 CCF38634.1 - 9.6e-05 22.3 0.5 5 6.9 0.1 4.0 2 1 1 4 4 4 2 Phospholipase/Carboxylesterase Ndr PF03096.14 CCF38634.1 - 0.0067 15.2 0.1 0.0096 14.6 0.1 1.4 1 1 0 1 1 1 1 Ndr family Cu-oxidase_3 PF07732.15 CCF38635.1 - 4.3e-39 133.2 2.4 4.3e-39 133.2 2.4 2.2 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 CCF38635.1 - 1.9e-37 128.0 10.3 4e-37 127.0 1.1 2.9 2 1 0 2 2 2 2 Multicopper oxidase Cu-oxidase PF00394.22 CCF38635.1 - 5.1e-36 124.2 0.0 1.5e-35 122.7 0.0 1.8 1 0 0 1 1 1 1 Multicopper oxidase TIP49_C PF17856.1 CCF38635.1 - 0.18 12.0 0.0 0.35 11.0 0.0 1.4 1 0 0 1 1 1 0 TIP49 AAA-lid domain PAN_1 PF00024.26 CCF38636.1 - 2.6e-05 24.1 0.7 3.6e-05 23.7 0.7 1.3 1 1 0 1 1 1 1 PAN domain PAN_3 PF08277.12 CCF38636.1 - 0.0034 17.1 1.2 0.005 16.6 0.9 1.6 1 1 0 1 1 1 1 PAN-like domain PAN_4 PF14295.6 CCF38636.1 - 0.15 12.0 5.5 0.32 10.9 5.5 1.8 1 1 0 1 1 1 0 PAN domain MFS_1 PF07690.16 CCF38640.1 - 2.9e-27 95.5 68.2 1.9e-21 76.4 41.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily YrvL PF14184.6 CCF38640.1 - 0.097 12.8 6.2 0.23 11.6 6.2 1.6 1 0 0 1 1 1 0 Regulatory protein YrvL PAN_4 PF14295.6 CCF38641.1 - 0.021 14.7 1.0 0.021 14.7 1.0 2.5 3 0 0 3 3 3 0 PAN domain Mucin PF01456.17 CCF38641.1 - 4.9 7.1 55.4 5.7 6.9 21.8 2.6 2 0 0 2 2 2 0 Mucin-like glycoprotein Ferric_reduct PF01794.19 CCF38642.1 - 1.5e-23 83.2 11.1 1.5e-23 83.2 11.1 2.2 2 0 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 CCF38642.1 - 2.2e-06 27.7 0.0 1.6e-05 24.9 0.0 2.2 1 1 0 1 1 1 1 FAD-binding domain SAC3_GANP PF03399.16 CCF38643.1 - 1.7e-73 247.6 0.0 2.1e-73 247.3 0.0 1.1 1 0 0 1 1 1 1 SAC3/GANP family LTV PF04180.14 CCF38644.1 - 7.9e-133 443.9 12.0 8.9e-133 443.7 12.0 1.0 1 0 0 1 1 1 1 Low temperature viability protein PBP PF01161.20 CCF38646.1 - 2.4e-16 60.3 0.1 3.6e-16 59.7 0.1 1.2 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein Pyr_redox_2 PF07992.14 CCF38647.1 - 1.2e-33 116.7 0.6 1.4e-33 116.4 0.6 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCF38647.1 - 3.8e-10 40.2 0.3 5e-09 36.6 0.1 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CCF38647.1 - 1.1e-06 28.7 0.3 0.69 9.9 0.0 3.5 3 0 0 3 3 3 3 FAD-NAD(P)-binding Pyr_redox_3 PF13738.6 CCF38647.1 - 3.6e-05 23.2 3.8 7.6e-05 22.1 1.1 2.4 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CCF38647.1 - 8.8e-05 21.8 1.6 0.039 13.1 0.1 2.7 2 1 1 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 CCF38647.1 - 0.00046 19.9 5.7 1.3 8.5 0.0 3.7 2 1 2 4 4 4 3 FAD dependent oxidoreductase HI0933_like PF03486.14 CCF38647.1 - 0.002 16.9 1.2 1.6 7.4 0.0 3.3 3 1 1 4 4 4 2 HI0933-like protein Lycopene_cycl PF05834.12 CCF38647.1 - 0.014 14.5 0.1 0.064 12.3 0.0 1.9 2 0 0 2 2 2 0 Lycopene cyclase protein Catalase_C PF18011.1 CCF38647.1 - 0.026 14.2 0.1 0.051 13.2 0.1 1.4 1 0 0 1 1 1 0 C-terminal domain found in long catalases ATP-synt PF00231.19 CCF38647.1 - 0.14 11.8 0.0 0.3 10.8 0.0 1.7 1 1 0 1 1 1 0 ATP synthase cobW PF02492.19 CCF38649.1 - 6.8e-41 139.8 0.0 1.1e-40 139.1 0.0 1.3 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain MobB PF03205.14 CCF38649.1 - 0.00056 19.8 0.0 0.0011 18.9 0.0 1.4 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B RsgA_GTPase PF03193.16 CCF38649.1 - 0.0065 16.4 0.0 4.7 7.1 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase Viral_helicase1 PF01443.18 CCF38649.1 - 0.0074 16.1 0.0 0.021 14.6 0.0 1.8 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.6 CCF38649.1 - 0.013 15.8 0.0 0.044 14.1 0.0 1.8 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.9 CCF38649.1 - 0.049 12.9 0.0 0.097 11.9 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) NTPase_1 PF03266.15 CCF38649.1 - 0.065 13.2 0.1 0.15 12.0 0.1 1.6 1 0 0 1 1 1 0 NTPase AAA_29 PF13555.6 CCF38649.1 - 0.071 12.9 0.2 0.34 10.7 0.1 2.1 2 0 0 2 2 2 0 P-loop containing region of AAA domain DUF463 PF04317.12 CCF38649.1 - 0.14 11.1 0.1 0.25 10.3 0.1 1.4 1 0 0 1 1 1 0 YcjX-like family, DUF463 tRNA-synt_1 PF00133.22 CCF38650.1 - 4.5e-48 163.9 0.0 4.2e-17 61.6 0.1 6.1 2 1 3 5 5 5 5 tRNA synthetases class I (I, L, M and V) tRNA-synt_1_2 PF13603.6 CCF38650.1 - 9.9e-42 142.6 0.0 1.8e-41 141.7 0.0 1.4 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1g PF09334.11 CCF38650.1 - 3.4e-29 101.8 1.0 6e-20 71.4 0.0 4.6 4 1 0 4 4 4 2 tRNA synthetases class I (M) Anticodon_1 PF08264.13 CCF38650.1 - 1.3e-14 54.4 0.0 2.5e-14 53.5 0.0 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 CCF38650.1 - 0.008 15.6 0.0 3.8 6.8 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1c PF00749.21 CCF38650.1 - 0.11 11.3 0.3 5.8 5.7 0.0 2.2 2 0 0 2 2 2 0 tRNA synthetases class I (E and Q), catalytic domain TIG PF01833.24 CCF38651.1 - 6.7e-11 42.1 0.2 2e-10 40.6 0.3 1.8 2 0 0 2 2 2 1 IPT/TIG domain Ank_2 PF12796.7 CCF38651.1 - 1.9e-07 31.6 0.0 4.2e-07 30.5 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 CCF38651.1 - 4.1e-07 30.2 0.1 0.00036 20.8 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 CCF38651.1 - 1.2e-06 28.7 0.1 3.5e-06 27.2 0.0 1.9 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 CCF38651.1 - 2.9e-05 24.5 0.0 0.00016 22.1 0.1 2.3 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCF38651.1 - 0.00014 22.0 0.1 0.03 14.9 0.0 2.8 2 0 0 2 2 2 1 Ankyrin repeat FAM176 PF14851.6 CCF38651.1 - 8.3 6.1 6.9 4.3 7.0 0.8 2.4 2 0 0 2 2 2 0 FAM176 family Cyclin_N PF00134.23 CCF38652.1 - 7.3e-39 132.4 0.2 1.6e-38 131.3 0.2 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 CCF38652.1 - 2.1e-11 43.9 0.2 8.8e-11 41.9 0.2 2.0 1 1 0 1 1 1 1 Cyclin, C-terminal domain Ribosomal_S5 PF00333.20 CCF38653.1 - 1.4e-26 92.2 1.6 2.1e-26 91.7 0.8 1.7 2 0 0 2 2 2 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 CCF38653.1 - 2.1e-23 81.6 0.0 3.5e-23 80.8 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain FoP_duplication PF13865.6 CCF38653.1 - 1.1 9.8 13.7 2.6 8.7 13.7 1.6 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 Rhodanese PF00581.20 CCF38654.1 - 3.7e-18 66.0 0.0 1.4e-10 41.6 0.0 2.3 2 1 0 2 2 2 2 Rhodanese-like domain DAP_epimerase PF01678.19 CCF38654.1 - 0.13 12.4 0.0 2.9 8.1 0.0 2.3 2 0 0 2 2 2 0 Diaminopimelate epimerase Fungal_trans PF04082.18 CCF38655.1 - 5.3e-14 51.9 0.3 1.1e-13 50.8 0.3 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 CCF38655.1 - 1.6e-10 40.8 11.6 9.6e-05 22.6 0.1 3.6 3 0 0 3 3 3 2 Zinc finger, C2H2 type Zn_clus PF00172.18 CCF38655.1 - 3e-06 27.2 10.0 3e-06 27.2 10.0 2.1 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-C2H2_4 PF13894.6 CCF38655.1 - 3.2e-06 27.5 14.6 0.0023 18.6 0.1 3.6 3 0 0 3 3 3 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 CCF38655.1 - 0.0013 19.1 6.1 0.0016 18.7 0.3 3.3 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_11 PF16622.5 CCF38655.1 - 0.01 15.6 5.9 1.9 8.3 2.7 2.9 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-C2H2_jaz PF12171.8 CCF38655.1 - 0.043 14.1 6.4 0.81 10.0 0.1 3.0 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CCF38655.1 - 0.067 13.6 4.8 4 8.0 0.8 3.3 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2HC_2 PF13913.6 CCF38655.1 - 0.1 12.5 3.8 7.4 6.6 0.2 2.6 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-C2H2_6 PF13912.6 CCF38655.1 - 0.12 12.4 0.1 0.12 12.4 0.1 1.9 2 0 0 2 2 2 0 C2H2-type zinc finger Peptidase_S8 PF00082.22 CCF38656.1 - 9.1e-21 74.4 0.0 1.5e-20 73.7 0.0 1.3 1 0 0 1 1 1 1 Subtilase family F-box-like PF12937.7 CCF38657.1 - 3.7e-06 26.7 1.2 4.7e-05 23.2 2.2 2.2 2 0 0 2 2 2 1 F-box-like SnoaL_4 PF13577.6 CCF38659.1 - 0.025 14.7 0.0 0.042 14.0 0.0 1.4 1 1 0 1 1 1 0 SnoaL-like domain SnoaL_2 PF12680.7 CCF38659.1 - 0.03 15.0 0.0 0.1 13.3 0.0 1.7 1 1 1 2 2 2 0 SnoaL-like domain TPR_12 PF13424.6 CCF38661.1 - 8.2e-41 138.2 40.5 4.8e-12 46.0 1.0 5.0 3 2 3 6 6 6 6 Tetratricopeptide repeat TPR_10 PF13374.6 CCF38661.1 - 5.1e-40 134.3 23.7 7.4e-08 32.0 0.2 8.0 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_1 PF00515.28 CCF38661.1 - 8.4e-15 53.9 16.2 0.011 15.5 0.1 6.9 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_2 PF07719.17 CCF38661.1 - 1.6e-13 49.7 23.4 0.012 15.7 0.2 7.6 7 1 0 7 7 7 4 Tetratricopeptide repeat TPR_19 PF14559.6 CCF38661.1 - 2.4e-12 47.2 19.0 0.0017 18.8 0.6 6.8 2 2 5 7 7 7 3 Tetratricopeptide repeat TPR_7 PF13176.6 CCF38661.1 - 6e-12 44.7 18.5 0.068 13.2 0.0 8.2 7 1 0 7 7 7 5 Tetratricopeptide repeat TPR_MalT PF17874.1 CCF38661.1 - 1.3e-09 37.9 19.2 0.00039 19.9 6.3 2.7 1 1 0 2 2 2 2 MalT-like TPR region TPR_8 PF13181.6 CCF38661.1 - 1.1e-07 31.5 16.9 0.51 10.7 0.2 7.1 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_20 PF14561.6 CCF38661.1 - 2e-06 28.0 22.4 0.0075 16.6 0.3 7.1 1 1 4 6 6 6 2 Tetratricopeptide repeat TPR_4 PF07721.14 CCF38661.1 - 2.9e-06 27.4 15.4 3.9 8.4 0.1 7.6 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_14 PF13428.6 CCF38661.1 - 5.6e-06 26.7 17.3 0.69 10.9 0.1 7.0 6 2 0 6 6 6 2 Tetratricopeptide repeat TPR_16 PF13432.6 CCF38661.1 - 6.2e-06 26.8 14.8 0.73 10.5 1.5 6.7 6 1 1 7 7 6 1 Tetratricopeptide repeat TPR_17 PF13431.6 CCF38661.1 - 7.8e-05 22.8 12.1 24 5.6 0.0 7.4 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_11 PF13414.6 CCF38661.1 - 0.00068 19.3 8.3 3.7 7.3 0.0 5.4 5 1 1 6 6 6 2 TPR repeat DUF1376 PF07120.11 CCF38661.1 - 0.011 16.1 0.3 0.082 13.2 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1376) RPN6_N PF18055.1 CCF38661.1 - 0.028 14.8 5.8 3.1 8.2 0.3 3.5 2 1 1 3 3 3 0 26S proteasome regulatory subunit RPN6 N-terminal domain Pkinase PF00069.25 CCF38662.1 - 0.0055 16.1 0.0 0.0079 15.6 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain mRNA_decap_C PF16741.5 CCF38662.1 - 0.059 12.7 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 mRNA-decapping enzyme C-terminus DUF2778 PF10908.8 CCF38662.1 - 0.16 12.3 0.0 0.2 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2778) SieB PF14163.6 CCF38662.1 - 0.19 11.2 0.0 0.27 10.7 0.0 1.2 1 0 0 1 1 1 0 Super-infection exclusion protein B MFS_1 PF07690.16 CCF38663.1 - 4e-35 121.4 12.0 4.1e-27 95.0 4.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 CCF38663.1 - 0.00069 19.0 0.3 0.0017 17.7 0.3 1.7 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB MFS_1_like PF12832.7 CCF38663.1 - 0.0033 16.4 1.7 0.0033 16.4 1.7 1.8 2 0 0 2 2 2 1 MFS_1 like family VIT1 PF01988.19 CCF38663.1 - 5.6 6.8 6.3 2.3 8.0 1.8 2.5 2 1 0 2 2 2 0 VIT family GMC_oxred_N PF00732.19 CCF38664.1 - 8.4e-45 153.4 0.0 1.2e-44 152.9 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCF38664.1 - 4.3e-31 108.4 0.1 1.5e-29 103.4 0.1 2.4 1 1 0 1 1 1 1 GMC oxidoreductase Pyr_redox_2 PF07992.14 CCF38664.1 - 0.038 13.2 0.0 0.059 12.6 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Peptidase_M28 PF04389.17 CCF38665.1 - 6.1e-39 133.8 0.0 9.2e-39 133.2 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 CCF38665.1 - 2.9e-10 40.0 0.1 6e-10 39.0 0.1 1.5 1 0 0 1 1 1 1 PA domain Peptidase_M20 PF01546.28 CCF38665.1 - 0.003 17.3 0.0 0.0057 16.4 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Fungal_trans PF04082.18 CCF38666.1 - 1.3e-18 67.0 0.0 2.2e-18 66.3 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF38666.1 - 2.1e-10 40.6 11.5 4.9e-10 39.4 11.5 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain HAUS-augmin3 PF14932.6 CCF38666.1 - 0.027 14.1 0.9 0.043 13.4 0.9 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 KIAA1430 PF13879.6 CCF38666.1 - 0.087 13.6 2.2 0.15 12.8 2.2 1.4 1 0 0 1 1 1 0 KIAA1430 homologue TerB_C PF15615.6 CCF38666.1 - 0.29 11.4 3.6 0.52 10.6 3.6 1.3 1 0 0 1 1 1 0 TerB-C domain DivIC PF04977.15 CCF38666.1 - 0.75 9.6 4.7 0.2 11.5 1.5 1.6 1 1 0 1 1 1 0 Septum formation initiator Spt20 PF12090.8 CCF38666.1 - 0.91 9.1 12.9 1.3 8.6 12.9 1.1 1 0 0 1 1 1 0 Spt20 family MFS_1 PF07690.16 CCF38667.1 - 1.5e-14 53.7 50.5 1.9e-13 50.1 50.1 2.4 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 CCF38667.1 - 1.3e-06 27.2 24.9 1.7e-06 26.7 24.9 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) ASFV_L11L PF05293.11 CCF38667.1 - 0.38 11.1 2.4 0.83 10.0 1.8 1.9 1 1 0 1 1 1 0 African swine fever virus (ASFV) L11L protein DUF5345 PF17280.2 CCF38667.1 - 3.4 7.7 14.0 4 7.5 0.0 4.3 4 0 0 4 4 4 0 Family of unknown function (DUF5345) Methyltransf_25 PF13649.6 CCF38668.1 - 5.5e-06 27.0 0.1 0.015 16.0 0.0 3.8 3 1 0 3 3 3 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF38668.1 - 0.00047 20.0 0.0 0.00082 19.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.6 CCF38668.1 - 0.0099 16.9 0.0 0.038 15.0 0.0 1.9 1 1 0 2 2 2 1 Methyltransferase domain PCMT PF01135.19 CCF38668.1 - 0.022 14.5 0.0 0.033 13.9 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 CCF38668.1 - 0.026 14.3 0.0 0.084 12.7 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_11 PF08241.12 CCF38668.1 - 0.036 14.7 0.0 4.2 8.1 0.0 2.7 1 1 0 1 1 1 0 Methyltransferase domain MetW PF07021.12 CCF38668.1 - 0.11 12.0 0.0 0.26 10.8 0.0 1.5 2 0 0 2 2 2 0 Methionine biosynthesis protein MetW TehB PF03848.14 CCF38668.1 - 0.14 11.6 0.0 0.22 10.9 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TehB Fungal_trans_2 PF11951.8 CCF38669.1 - 2.8e-08 33.0 0.1 4e-08 32.5 0.1 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF38669.1 - 1.2e-07 31.7 11.4 2.1e-07 30.9 11.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_hydro_64 PF16483.5 CCF38670.1 - 3.1e-93 313.0 1.0 7.1e-67 226.3 0.0 2.0 1 1 1 2 2 2 2 Beta-1,3-glucanase eIF3_subunit PF08597.10 CCF38671.1 - 2.2e-73 247.1 23.9 2.5e-73 247.0 23.9 1.0 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit DUF572 PF04502.13 CCF38671.1 - 0.81 9.2 18.5 1.3 8.6 18.5 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) LicD PF04991.13 CCF38671.1 - 0.93 9.6 3.8 0.39 10.8 0.8 1.9 1 1 1 2 2 2 0 LicD family Nop53 PF07767.11 CCF38671.1 - 1 8.7 26.0 0.15 11.4 18.7 2.0 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) CCSAP PF15748.5 CCF38671.1 - 2.9 8.0 16.4 0.48 10.5 11.1 1.9 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated CDC45 PF02724.14 CCF38671.1 - 3.9 5.7 14.1 5.7 5.1 14.1 1.2 1 0 0 1 1 1 0 CDC45-like protein Ribosomal_S25 PF03297.15 CCF38671.1 - 6.3 7.1 18.8 0.42 10.8 2.3 2.6 2 0 0 2 2 2 0 S25 ribosomal protein Endonuc_Holl PF10107.9 CCF38671.1 - 7.4 6.4 9.5 46 3.8 0.0 2.4 2 0 0 2 2 2 0 Endonuclease related to archaeal Holliday junction resolvase MDM31_MDM32 PF08118.11 CCF38672.1 - 5.8e-49 167.2 0.5 2.8e-48 164.9 0.5 1.8 1 1 0 1 1 1 1 Yeast mitochondrial distribution and morphology (MDM) proteins DUF3526 PF12040.8 CCF38672.1 - 0.15 12.6 0.0 0.19 12.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3526) AMP-binding PF00501.28 CCF38673.1 - 4.2e-100 335.3 0.0 5.3e-100 335.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CCF38673.1 - 7.5e-14 52.5 0.0 1.7e-13 51.3 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Acetyltransf_10 PF13673.7 CCF38674.1 - 0.057 13.4 0.0 0.073 13.0 0.0 1.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain IstB_IS21_ATP PF08483.11 CCF38674.1 - 0.083 12.8 0.0 0.57 10.1 0.0 2.1 2 0 0 2 2 2 0 IstB-like ATP binding N-terminal NmrA PF05368.13 CCF38677.1 - 4.4e-18 65.7 0.1 5.7e-18 65.3 0.1 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CCF38677.1 - 1.2e-14 54.6 0.6 2e-14 53.9 0.4 1.6 1 1 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 CCF38677.1 - 1.7e-05 25.1 0.4 8e-05 22.9 0.0 2.1 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain DapB_N PF01113.20 CCF38677.1 - 6.9e-05 23.0 0.1 0.00014 22.0 0.1 1.5 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Shikimate_DH PF01488.20 CCF38677.1 - 0.0045 17.1 0.0 0.01 15.9 0.0 1.6 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Epimerase PF01370.21 CCF38677.1 - 0.011 15.2 0.0 0.022 14.2 0.0 1.5 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family DXP_reductoisom PF02670.16 CCF38677.1 - 0.016 15.9 0.5 0.049 14.3 0.5 2.0 1 1 0 1 1 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase NAD_binding_3 PF03447.16 CCF38677.1 - 0.029 15.0 0.5 0.56 10.9 0.1 2.3 2 0 0 2 2 2 0 Homoserine dehydrogenase, NAD binding domain KR PF08659.10 CCF38677.1 - 0.055 13.4 0.2 0.12 12.3 0.2 1.7 1 1 0 1 1 1 0 KR domain Semialdhyde_dh PF01118.24 CCF38677.1 - 0.062 13.7 0.1 0.13 12.7 0.1 1.5 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain CbiJ PF02571.14 CCF38677.1 - 0.11 12.0 0.4 0.17 11.3 0.0 1.5 2 0 0 2 2 2 0 Precorrin-6x reductase CbiJ/CobK GMC_oxred_N PF00732.19 CCF38680.1 - 2.1e-53 181.7 0.1 2.7e-53 181.3 0.1 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCF38680.1 - 3.1e-30 105.6 0.1 6.5e-30 104.6 0.1 1.6 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.12 CCF38680.1 - 1.3e-07 31.0 0.4 0.00033 19.8 0.2 2.3 2 0 0 2 2 2 2 Lycopene cyclase protein Pyr_redox_3 PF13738.6 CCF38680.1 - 3.5e-07 29.8 0.0 0.0011 18.2 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CCF38680.1 - 8.7e-06 25.1 0.2 0.00092 18.4 0.1 2.2 2 0 0 2 2 2 2 FAD binding domain Thi4 PF01946.17 CCF38680.1 - 2.8e-05 23.5 0.3 0.025 13.8 0.1 2.8 3 0 0 3 3 3 2 Thi4 family DAO PF01266.24 CCF38680.1 - 5.2e-05 23.0 3.8 0.00028 20.6 3.7 2.1 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCF38680.1 - 8.6e-05 21.9 0.1 0.00076 18.8 0.1 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCF38680.1 - 9.1e-05 22.6 0.1 0.00022 21.4 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 CCF38680.1 - 0.0058 15.9 0.8 0.022 14.0 0.4 1.9 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.14 CCF38680.1 - 0.022 13.5 0.4 0.14 10.8 0.2 1.9 2 0 0 2 2 2 0 HI0933-like protein Trp_halogenase PF04820.14 CCF38680.1 - 0.054 12.3 0.3 0.08 11.8 0.3 1.2 1 0 0 1 1 1 0 Tryptophan halogenase Pyr_redox PF00070.27 CCF38680.1 - 0.12 12.9 0.7 0.33 11.6 0.7 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase p450 PF00067.22 CCF38681.1 - 2.1e-33 115.8 0.0 2.5e-33 115.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 APH PF01636.23 CCF38682.1 - 1.5e-18 67.6 0.3 2.4e-18 66.9 0.3 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CCF38682.1 - 5.4e-05 22.9 0.0 9.6e-05 22.1 0.0 1.4 2 0 0 2 2 2 1 Choline/ethanolamine kinase RIO1 PF01163.22 CCF38682.1 - 0.032 13.8 0.0 4.2 6.9 0.0 2.3 2 0 0 2 2 2 0 RIO1 family MFS_1 PF07690.16 CCF38683.1 - 1.8e-43 148.9 47.1 7.8e-43 146.7 47.1 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 CCF38683.1 - 3.5e-11 42.2 13.1 5.4e-11 41.6 13.1 1.3 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF3824 PF12868.7 CCF38683.1 - 1 10.0 3.1 1.6 9.4 3.1 1.2 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) OATP PF03137.20 CCF38683.1 - 1.2 7.3 12.6 1.2 7.4 4.8 2.5 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family TMEM100 PF16311.5 CCF38683.1 - 4.5 6.9 7.2 3 7.5 0.0 3.1 3 0 0 3 3 3 0 Transmembrane protein 100 TIP120 PF08623.10 CCF38684.1 - 3.1e-71 238.5 0.5 2.4e-69 232.4 0.0 3.5 3 0 0 3 3 3 1 TATA-binding protein interacting (TIP20) HEAT_2 PF13646.6 CCF38684.1 - 2.4e-12 47.0 11.8 0.36 11.3 1.4 8.4 8 1 0 9 9 9 4 HEAT repeats HEAT PF02985.22 CCF38684.1 - 4.9e-07 29.5 20.9 0.18 12.1 0.1 10.9 12 1 0 12 12 12 3 HEAT repeat Adaptin_N PF01602.20 CCF38684.1 - 2.7e-05 22.9 10.6 0.38 9.3 0.1 5.4 5 2 0 5 5 5 3 Adaptin N terminal region RTP1_C1 PF10363.9 CCF38684.1 - 0.00011 22.3 9.3 0.38 11.0 0.0 5.5 6 1 0 6 6 6 2 Required for nuclear transport of RNA pol II C-terminus 1 Cnd1 PF12717.7 CCF38684.1 - 0.001 19.1 15.6 0.63 10.1 0.0 5.9 5 1 1 6 6 6 3 non-SMC mitotic condensation complex subunit 1 DUF3361 PF11841.8 CCF38684.1 - 0.034 14.1 8.4 2.1 8.3 0.0 4.7 4 1 0 5 5 5 0 Domain of unknown function (DUF3361) RIX1 PF08167.12 CCF38684.1 - 0.099 12.4 0.4 2.4 7.8 0.0 3.4 4 0 0 4 4 4 0 rRNA processing/ribosome biogenesis CDC27 PF09507.10 CCF38685.1 - 0.061 12.7 49.4 0.077 12.4 49.4 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Mitofilin PF09731.9 CCF38685.1 - 3.7 6.3 40.7 4.7 5.9 40.7 1.3 1 0 0 1 1 1 0 Mitochondrial inner membrane protein PhoLip_ATPase_C PF16212.5 CCF38686.1 - 2.4e-74 250.2 22.0 2.4e-74 250.2 22.0 2.1 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 CCF38686.1 - 1.6e-23 82.1 3.9 1.2e-22 79.3 0.1 3.5 4 0 0 4 4 4 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.20 CCF38686.1 - 4e-14 52.5 0.0 1.3e-13 50.9 0.0 1.8 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 CCF38686.1 - 4.7e-14 53.2 0.0 6.6e-06 26.6 0.0 3.3 2 1 1 3 3 3 3 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CCF38686.1 - 1.4e-12 47.5 0.0 1.2e-11 44.5 0.0 2.3 2 0 0 2 2 2 1 Cation transport ATPase (P-type) GGDEF_2 PF17853.1 CCF38686.1 - 0.00072 19.8 0.3 0.2 11.9 0.0 2.6 2 0 0 2 2 2 1 GGDEF-like domain Hydrolase_3 PF08282.12 CCF38686.1 - 0.0018 18.1 0.0 0.012 15.4 0.0 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 CCF38686.1 - 0.0083 16.5 0.0 3.9 7.8 0.0 2.6 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase DUF2162 PF09930.9 CCF38686.1 - 1.2 8.6 11.0 0.48 9.8 6.6 2.2 2 0 0 2 2 2 0 Predicted transporter (DUF2162) Mito_carr PF00153.27 CCF38687.1 - 1.4e-37 127.4 9.4 6.3e-16 58.1 0.2 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein BetaGal_dom2 PF10435.9 CCF38689.1 - 8.5e-60 201.7 7.2 1.4e-59 201.0 7.2 1.3 1 0 0 1 1 1 1 Beta-galactosidase, domain 2 BetaGal_dom4_5 PF13364.6 CCF38689.1 - 7.3e-53 178.0 1.7 3.7e-25 88.7 0.0 2.7 2 0 0 2 2 2 2 Beta-galactosidase jelly roll domain BetaGal_dom3 PF13363.6 CCF38689.1 - 4.2e-20 71.1 0.0 9.3e-20 70.0 0.0 1.6 1 0 0 1 1 1 1 Beta-galactosidase, domain 3 SelB-wing_3 PF09107.11 CCF38689.1 - 0.063 12.9 0.0 0.13 11.9 0.0 1.5 1 0 0 1 1 1 0 Elongation factor SelB, winged helix SNF2_N PF00176.23 CCF38691.1 - 8.3e-66 222.1 1.0 8.3e-66 222.1 1.0 2.2 2 0 0 2 2 2 1 SNF2 family N-terminal domain DBINO PF13892.6 CCF38691.1 - 3.1e-48 163.5 19.7 3.1e-48 163.5 19.7 6.4 8 1 0 8 8 8 1 DNA-binding domain ResIII PF04851.15 CCF38691.1 - 3.7e-08 33.6 0.0 3.7e-08 33.6 0.0 3.1 3 1 0 3 3 3 1 Type III restriction enzyme, res subunit Fe_hyd_lg_C PF02906.14 CCF38691.1 - 0.069 12.8 1.2 0.17 11.6 1.2 1.6 1 0 0 1 1 1 0 Iron only hydrogenase large subunit, C-terminal domain Piwi PF02171.17 CCF38692.1 - 4.2e-81 272.5 0.0 6e-81 272.0 0.0 1.2 1 0 0 1 1 1 1 Piwi domain ArgoN PF16486.5 CCF38692.1 - 1.5e-21 77.5 0.0 1.3e-20 74.4 0.0 2.3 2 0 0 2 2 2 1 N-terminal domain of argonaute ArgoL1 PF08699.10 CCF38692.1 - 6.4e-16 57.8 0.1 5.4e-15 54.8 0.1 2.5 2 0 0 2 2 2 1 Argonaute linker 1 domain ArgoL2 PF16488.5 CCF38692.1 - 1.4e-11 44.6 0.0 6.8e-11 42.3 0.0 2.3 2 0 0 2 2 2 1 Argonaute linker 2 domain PAZ PF02170.22 CCF38692.1 - 1.6e-11 44.2 0.0 3e-11 43.3 0.0 1.4 1 0 0 1 1 1 1 PAZ domain ArgoMid PF16487.5 CCF38692.1 - 1.6e-07 31.5 2.1 2.4e-07 30.9 0.1 2.4 3 0 0 3 3 3 1 Mid domain of argonaute SGT1 PF07093.11 CCF38693.1 - 5e-94 315.8 12.9 3.5e-85 286.6 0.0 2.1 2 0 0 2 2 2 2 SGT1 protein AAA_15 PF13175.6 CCF38694.1 - 1.8e-15 57.5 0.0 4.2e-15 56.3 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_23 PF13476.6 CCF38694.1 - 7.6e-15 56.0 26.9 1.6e-12 48.4 22.3 3.5 2 1 0 2 2 2 1 AAA domain SMC_N PF02463.19 CCF38694.1 - 3e-10 39.9 0.2 3e-10 39.9 0.2 2.0 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain Spc7 PF08317.11 CCF38694.1 - 0.00067 18.6 13.3 0.00067 18.6 13.3 3.3 1 1 2 3 3 3 1 Spc7 kinetochore protein AAA_21 PF13304.6 CCF38694.1 - 0.00074 19.4 4.0 0.0013 18.6 2.6 2.1 1 1 1 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CCF38694.1 - 0.0015 18.3 0.0 0.0034 17.1 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain WXG100 PF06013.12 CCF38694.1 - 0.0055 16.9 6.3 0.0055 16.9 6.3 2.9 2 1 1 3 3 2 1 Proteins of 100 residues with WXG DUF745 PF05335.13 CCF38694.1 - 0.0071 16.1 29.6 0.042 13.6 16.1 3.4 1 1 1 3 3 3 2 Protein of unknown function (DUF745) Muted PF14942.6 CCF38694.1 - 0.014 15.7 4.5 0.014 15.7 4.5 3.3 2 1 2 4 4 4 0 Organelle biogenesis, Muted-like protein DUF2813 PF11398.8 CCF38694.1 - 0.024 13.9 0.0 0.024 13.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2813) ABC_tran PF00005.27 CCF38694.1 - 0.08 13.5 0.0 0.08 13.5 0.0 3.2 2 1 0 2 2 1 0 ABC transporter Baculo_p24 PF05073.12 CCF38694.1 - 0.08 12.7 10.2 0.24 11.2 0.6 2.6 1 1 1 2 2 2 0 Baculovirus P24 capsid protein DASH_Duo1 PF08651.10 CCF38694.1 - 0.24 11.2 3.1 15 5.4 0.8 3.0 2 0 0 2 2 2 0 DASH complex subunit Duo1 Laminin_II PF06009.12 CCF38694.1 - 0.25 11.4 20.8 0.35 10.9 4.8 3.5 2 1 1 3 3 3 0 Laminin Domain II AAA_22 PF13401.6 CCF38694.1 - 0.34 11.2 2.4 1.3 9.3 0.0 2.7 2 1 0 2 2 2 0 AAA domain DUF812 PF05667.11 CCF38694.1 - 0.51 9.2 30.8 0.17 10.7 23.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF812) ComP_DUS PF16732.5 CCF38694.1 - 0.63 11.0 3.2 0.6 11.0 0.5 2.4 2 0 0 2 2 2 0 Type IV minor pilin ComP, DNA uptake sequence receptor AAA_13 PF13166.6 CCF38694.1 - 0.86 8.2 33.4 0.17 10.5 18.2 3.3 2 1 0 3 3 3 0 AAA domain Occludin_ELL PF07303.13 CCF38694.1 - 1.4 9.7 17.8 2.4 8.9 4.6 3.7 2 1 1 3 3 3 0 Occludin homology domain Exonuc_VII_L PF02601.15 CCF38694.1 - 1.9 8.0 29.2 1.8e+04 -7.4 29.2 3.0 1 1 0 1 1 0 0 Exonuclease VII, large subunit Filament PF00038.21 CCF38694.1 - 6.7 6.2 33.6 10 5.6 18.0 3.1 1 1 2 3 3 3 0 Intermediate filament protein Lebercilin PF15619.6 CCF38694.1 - 8.7 5.9 39.4 3.5 7.3 9.3 4.1 1 1 1 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease DUF1664 PF07889.12 CCF38694.1 - 8.8 6.4 19.0 0.84 9.7 4.7 3.9 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) Zn_clus PF00172.18 CCF38695.1 - 7.9e-09 35.5 4.9 1.1e-08 35.0 4.9 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Cu_amine_oxid PF01179.20 CCF38696.1 - 8.1e-121 403.8 7.7 9.8e-121 403.5 7.7 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain DUF1965 PF09248.10 CCF38696.1 - 8.8e-32 108.7 1.3 2.4e-31 107.3 1.3 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1965) Cu_amine_oxidN2 PF02727.16 CCF38696.1 - 1e-05 25.7 0.0 2.4e-05 24.5 0.0 1.6 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain Peptidase_S8 PF00082.22 CCF38697.1 - 4.4e-46 157.5 0.1 8.1e-46 156.6 0.1 1.4 1 0 0 1 1 1 1 Subtilase family fn3_5 PF06280.12 CCF38697.1 - 2.8e-07 31.2 0.0 5.5e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 Fn3-like domain UQ_con PF00179.26 CCF38700.1 - 8.3e-36 122.7 0.0 4.7e-22 78.1 0.0 2.2 2 0 0 2 2 2 2 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 CCF38700.1 - 0.0019 17.9 0.0 0.24 11.1 0.0 2.4 2 0 0 2 2 2 2 Prokaryotic E2 family B FDC-SP PF15215.6 CCF38700.1 - 0.057 14.0 0.0 0.13 12.8 0.0 1.6 1 0 0 1 1 1 0 Follicular dendritic cell secreted peptide DUF5390 PF17365.2 CCF38700.1 - 0.11 12.8 0.6 0.19 12.0 0.6 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5390) DUF4251 PF14059.6 CCF38701.1 - 0.15 12.1 0.0 0.18 11.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4251) Helicase_C PF00271.31 CCF38702.1 - 5.6e-18 65.3 0.0 1.3e-17 64.1 0.0 1.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 CCF38702.1 - 0.0077 15.5 0.0 0.0091 15.2 0.0 1.2 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Homez PF11569.8 CCF38702.1 - 0.1 12.1 0.1 0.3 10.6 0.1 1.7 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez MFS_1 PF07690.16 CCF38703.1 - 2.7e-26 92.3 44.8 5.5e-23 81.4 33.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily UCH_1 PF13423.6 CCF38705.1 - 1.7e-102 343.3 0.0 2.6e-102 342.7 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RNase_T PF00929.24 CCF38705.1 - 7.8e-23 81.8 0.0 1.3e-22 81.1 0.0 1.4 1 0 0 1 1 1 1 Exonuclease LIP1 PF15904.5 CCF38705.1 - 0.0098 16.2 0.1 0.29 11.5 0.0 2.5 2 0 0 2 2 2 1 LKB1 serine/threonine kinase interacting protein 1 ANAPC4_WD40 PF12894.7 CCF38705.1 - 0.012 15.8 0.0 7.7 6.9 0.0 2.7 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain UCH PF00443.29 CCF38705.1 - 0.017 14.6 0.0 0.048 13.1 0.0 1.8 1 1 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase adh_short_C2 PF13561.6 CCF38706.1 - 4.9e-41 140.8 0.8 1.8e-39 135.7 0.8 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF38706.1 - 6.2e-38 130.2 0.3 1.2e-37 129.2 0.3 1.5 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF38706.1 - 2.9e-11 43.6 0.5 6.3e-11 42.5 0.5 1.7 1 1 0 1 1 1 1 KR domain Pyr_redox PF00070.27 CCF38706.1 - 0.014 15.9 0.3 0.063 13.8 0.3 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Polysacc_synt_2 PF02719.15 CCF38706.1 - 0.024 13.8 0.0 0.045 12.9 0.0 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein DUF3611 PF12263.8 CCF38706.1 - 0.079 12.9 0.3 0.14 12.1 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3611) NAD_binding_10 PF13460.6 CCF38706.1 - 0.08 12.8 0.4 0.69 9.8 0.0 2.1 1 1 1 2 2 2 0 NAD(P)H-binding Shikimate_DH PF01488.20 CCF38706.1 - 0.19 11.8 0.0 0.32 11.0 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase BUD22 PF09073.10 CCF38707.1 - 5.7e-100 335.7 48.7 1.3e-99 334.5 48.7 1.5 1 1 0 1 1 1 1 BUD22 Antifungal_prot PF11402.8 CCF38708.1 - 0.0039 17.4 1.9 0.0084 16.3 1.9 1.5 1 0 0 1 1 1 1 Antifungal protein Sperm_Ag_HE2 PF05324.13 CCF38708.1 - 0.079 13.4 0.0 0.11 12.9 0.0 1.2 1 0 0 1 1 1 0 Sperm antigen HE2 DUF4167 PF13763.6 CCF38708.1 - 0.17 12.1 0.0 0.24 11.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4167) BBP1_C PF15272.6 CCF38709.1 - 0.0066 16.3 0.8 0.014 15.2 0.8 1.5 1 0 0 1 1 1 1 Spindle pole body component BBP1, C-terminal CdvA PF18822.1 CCF38709.1 - 0.057 13.3 0.1 0.13 12.1 0.1 1.5 1 0 0 1 1 1 0 CdvA-like coiled-coil domain Lipocalin_5 PF13924.6 CCF38710.1 - 7.5e-30 103.6 0.0 8.5e-30 103.4 0.0 1.0 1 0 0 1 1 1 1 Lipocalin-like domain RNase_H PF00075.24 CCF38711.1 - 1.6e-16 60.8 0.0 6e-16 58.9 0.0 1.8 1 1 0 1 1 1 1 RNase H RVT_3 PF13456.6 CCF38711.1 - 0.024 14.4 0.0 4.8 7.0 0.0 2.3 2 0 0 2 2 2 0 Reverse transcriptase-like DUF4139 PF13598.6 CCF38713.1 - 1.1e-39 136.3 0.5 2.2e-39 135.4 0.5 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4139) DUF4140 PF13600.6 CCF38713.1 - 8.5e-26 90.3 0.2 8.5e-26 90.3 0.2 3.8 4 0 0 4 4 4 1 N-terminal domain of unknown function (DUF4140) DUF2608 PF11019.8 CCF38713.1 - 0.063 12.8 0.0 0.13 11.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2608) RSN1_TM PF13967.6 CCF38714.1 - 4.6e-07 29.7 0.2 5.1e-07 29.6 0.2 1.1 1 0 0 1 1 1 1 Late exocytosis, associated with Golgi transport Aldolase_II PF00596.21 CCF38715.1 - 8.4e-21 74.8 0.1 9.5e-21 74.6 0.1 1.0 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain CN_hydrolase PF00795.22 CCF38716.1 - 4.9e-33 114.6 0.0 6.7e-33 114.1 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Fungal_trans_2 PF11951.8 CCF38717.1 - 1.2e-17 63.8 0.2 1.5e-17 63.5 0.2 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain HhH-GPD PF00730.25 CCF38718.1 - 6.3e-15 55.6 0.0 1.3e-14 54.6 0.0 1.5 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein PALP PF00291.25 CCF38720.1 - 2.4e-37 129.0 0.3 5.5e-37 127.8 0.3 1.5 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme PALP PF00291.25 CCF38721.1 - 1.5e-10 41.0 0.0 1.9e-10 40.6 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Arginosuc_synth PF00764.19 CCF38722.1 - 5.1e-38 131.4 0.0 3.3e-24 85.9 0.0 2.1 1 1 1 2 2 2 2 Arginosuccinate synthase GREB1 PF15782.5 CCF38723.1 - 0.0036 14.5 16.8 0.0048 14.1 16.8 1.4 1 0 0 1 1 1 1 Gene regulated by oestrogen in breast cancer zf-Di19 PF05605.12 CCF38723.1 - 0.017 15.4 0.0 0.043 14.1 0.0 1.7 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding UPF0242 PF06785.11 CCF38723.1 - 0.019 15.1 1.1 0.019 15.1 1.1 2.4 2 0 0 2 2 1 0 Uncharacterised protein family (UPF0242) N-terminus zf-C2H2_4 PF13894.6 CCF38723.1 - 0.038 14.8 0.1 0.1 13.5 0.1 1.7 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2HC_2 PF13913.6 CCF38723.1 - 0.058 13.3 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 zinc-finger of a C2HC-type zf-ribbon_3 PF13248.6 CCF38723.1 - 0.071 12.6 0.2 0.13 11.7 0.2 1.4 1 0 0 1 1 1 0 zinc-ribbon domain zf-C2H2 PF00096.26 CCF38723.1 - 0.1 13.1 0.1 0.22 12.0 0.1 1.6 1 0 0 1 1 1 0 Zinc finger, C2H2 type SLC12 PF03522.15 CCF38723.1 - 0.6 9.1 24.3 0.1 11.6 18.2 2.4 2 0 0 2 2 2 0 Solute carrier family 12 FAM76 PF16046.5 CCF38723.1 - 2 7.7 23.7 0.56 9.5 17.0 2.5 2 0 0 2 2 2 0 FAM76 protein SID-1_RNA_chan PF13965.6 CCF38723.1 - 2.4 6.5 6.8 3.8 5.8 6.8 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Zip PF02535.22 CCF38723.1 - 3 7.0 10.6 6.3 5.9 10.6 1.6 1 0 0 1 1 1 0 ZIP Zinc transporter AAT PF03417.16 CCF38723.1 - 4.1 7.0 12.9 8.6 6.0 12.9 1.5 1 0 0 1 1 1 0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase Cellulose_synt PF03552.14 CCF38723.1 - 6 5.2 9.4 9.5 4.6 9.4 1.2 1 0 0 1 1 1 0 Cellulose synthase DUF4407 PF14362.6 CCF38723.1 - 6.6 6.0 35.0 0.91 8.8 0.6 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4407) eIF-3_zeta PF05091.12 CCF38723.1 - 8.6 5.2 36.5 9.1 5.1 0.3 2.5 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Otopetrin PF03189.13 CCF38723.1 - 8.8 5.0 9.6 17 4.1 9.6 1.5 1 0 0 1 1 1 0 Otopetrin FAM101 PF15068.6 CCF38723.1 - 8.8 6.2 14.1 1.4 8.9 9.2 2.1 2 0 0 2 2 2 0 FAM101 family Abhydrolase_3 PF07859.13 CCF38725.1 - 4.6e-32 111.6 0.0 5.9e-32 111.2 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 CCF38725.1 - 2.8e-13 49.5 0.0 4.1e-13 48.9 0.0 1.1 1 0 0 1 1 1 1 Steryl acetyl hydrolase AraC_binding_2 PF14525.6 CCF38725.1 - 0.045 13.4 1.4 0.13 11.9 0.1 2.2 2 1 1 3 3 3 0 AraC-binding-like domain Peptidase_S9 PF00326.21 CCF38725.1 - 0.049 13.1 0.0 1.1 8.6 0.0 2.1 2 0 0 2 2 2 0 Prolyl oligopeptidase family Peptidase_M14 PF00246.24 CCF38727.1 - 7.2e-17 62.1 0.0 1.5e-15 57.8 0.0 2.0 1 1 1 2 2 2 2 Zinc carboxypeptidase AstE_AspA PF04952.14 CCF38727.1 - 0.022 13.8 0.0 0.034 13.2 0.0 1.3 1 0 0 1 1 1 0 Succinylglutamate desuccinylase / Aspartoacylase family MFS_1 PF07690.16 CCF38728.1 - 5e-18 65.1 41.4 1.5e-11 43.9 23.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF38728.1 - 1.1e-10 40.9 24.6 6.1e-09 35.3 24.2 3.0 1 1 0 1 1 1 1 Sugar (and other) transporter IU_nuc_hydro PF01156.19 CCF38729.1 - 2.2e-15 57.0 0.0 2.9e-15 56.6 0.0 1.2 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase APH PF01636.23 CCF38730.1 - 1e-08 35.4 0.0 4.2e-08 33.4 0.0 2.1 1 1 0 1 1 1 1 Phosphotransferase enzyme family Prp18 PF02840.15 CCF38731.1 - 0.0038 17.3 4.5 0.082 13.0 0.0 2.3 1 1 1 2 2 2 2 Prp18 domain TANGO2 PF05742.12 CCF38731.1 - 0.074 13.1 1.0 0.15 12.1 1.0 1.4 1 0 0 1 1 1 0 Transport and Golgi organisation 2 VCBS PF13517.6 CCF38732.1 - 9.6e-17 61.3 26.8 5.3e-09 36.5 8.2 3.1 1 1 2 3 3 3 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Dockerin_1 PF00404.18 CCF38732.1 - 0.002 18.3 0.8 1.1 9.5 0.1 2.8 3 0 0 3 3 3 2 Dockerin type I domain TcdB_toxin_midN PF12256.8 CCF38732.1 - 0.0042 16.5 1.0 2 7.8 0.0 2.4 1 1 2 3 3 3 2 Insecticide toxin TcdB middle/N-terminal region FG-GAP PF01839.23 CCF38732.1 - 0.0056 16.8 10.8 0.42 10.8 2.8 3.2 2 1 0 2 2 2 2 FG-GAP repeat PliI PF16743.5 CCF38732.1 - 0.052 13.3 0.1 1.1 9.0 0.1 2.2 2 0 0 2 2 2 0 Periplasmic lysozyme inhibitor of I-type lysozyme EF-hand_5 PF13202.6 CCF38732.1 - 2 8.0 4.4 19 5.0 0.2 2.9 3 0 0 3 3 3 0 EF hand MFS_1 PF07690.16 CCF38735.1 - 1.4e-32 113.0 45.1 7.8e-32 110.6 45.1 2.5 1 1 0 1 1 1 1 Major Facilitator Superfamily OATP PF03137.20 CCF38735.1 - 0.0003 19.2 3.5 0.0003 19.2 3.5 1.7 2 0 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family DUF2919 PF11143.8 CCF38735.1 - 0.0043 17.4 0.8 0.1 12.9 0.2 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF2919) Gluconate_2-dh3 PF13618.6 CCF38736.1 - 0.16 12.2 0.0 0.3 11.3 0.0 1.4 1 0 0 1 1 1 0 Gluconate 2-dehydrogenase subunit 3 PHO4 PF01384.20 CCF38738.1 - 1.1e-100 337.0 15.9 1.3e-100 336.8 15.9 1.0 1 0 0 1 1 1 1 Phosphate transporter family UPF0444 PF15475.6 CCF38738.1 - 1.4 9.3 8.4 1.2 9.4 0.7 2.7 2 0 0 2 2 2 0 Transmembrane protein C12orf23, UPF0444 SUR7 PF06687.12 CCF38739.1 - 1.6e-20 73.7 3.1 2.3e-20 73.2 3.1 1.3 1 0 0 1 1 1 1 SUR7/PalI family EphA2_TM PF14575.6 CCF38739.1 - 0.007 17.2 1.4 0.17 12.8 0.0 2.9 3 0 0 3 3 3 1 Ephrin type-A receptor 2 transmembrane domain Claudin_2 PF13903.6 CCF38739.1 - 0.0073 16.1 7.5 0.03 14.1 0.3 2.8 1 1 1 3 3 3 2 PMP-22/EMP/MP20/Claudin tight junction Trp_oprn_chp PF09534.10 CCF38739.1 - 0.017 14.9 1.7 0.077 12.8 0.0 2.4 2 1 1 3 3 3 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) WBP-1 PF11669.8 CCF38739.1 - 0.037 14.6 0.0 0.07 13.8 0.0 1.4 1 0 0 1 1 1 0 WW domain-binding protein 1 DUF1772 PF08592.11 CCF38739.1 - 0.12 12.7 3.7 0.079 13.3 0.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1772) Herpes_gE PF02480.16 CCF38739.1 - 0.14 10.9 2.5 2.3 6.9 0.0 2.1 1 1 1 2 2 2 0 Alphaherpesvirus glycoprotein E PAG PF15347.6 CCF38739.1 - 0.17 10.8 0.0 0.26 10.2 0.0 1.2 1 0 0 1 1 1 0 Phosphoprotein associated with glycosphingolipid-enriched Phage_holin_3_6 PF07332.11 CCF38739.1 - 0.27 11.3 13.7 0.29 11.2 2.5 3.0 3 0 0 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III LYRIC PF15686.5 CCF38739.1 - 0.28 10.7 0.0 0.43 10.1 0.0 1.2 1 0 0 1 1 1 0 Lysine-rich CEACAM1 co-isolated protein family LapA_dom PF06305.11 CCF38739.1 - 0.93 9.4 0.0 0.93 9.4 0.0 2.7 2 1 0 2 2 1 0 Lipopolysaccharide assembly protein A domain DUF2975 PF11188.8 CCF38739.1 - 1.4 8.8 6.6 0.29 11.0 1.8 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF2975) DUF2207 PF09972.9 CCF38739.1 - 2.8 6.6 6.5 16 4.1 0.0 2.1 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) DUF5527 PF17665.1 CCF38739.1 - 5.8 6.5 7.9 1.3 8.5 0.0 2.8 3 0 0 3 3 3 0 Family of unknown function (DUF5527) APH PF01636.23 CCF38740.1 - 2.2e-10 40.9 6.2 4.5e-09 36.6 6.2 2.2 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CCF38740.1 - 0.086 12.4 0.0 1.1 8.7 0.0 2.1 2 0 0 2 2 2 0 Choline/ethanolamine kinase WD40 PF00400.32 CCF38741.1 - 1.3e-07 32.2 16.8 0.012 16.5 0.4 5.6 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF38741.1 - 0.0019 18.4 0.0 1.1 9.7 0.0 3.9 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain MraZ PF02381.18 CCF38741.1 - 0.082 12.9 0.0 16 5.6 0.0 2.6 2 0 0 2 2 2 0 MraZ protein, putative antitoxin-like MR_MLE_C PF13378.6 CCF38742.1 - 0.024 14.2 0.0 0.037 13.6 0.0 1.3 1 0 0 1 1 1 0 Enolase C-terminal domain-like Suc_Fer-like PF06999.12 CCF38742.1 - 0.047 13.6 0.0 0.051 13.4 0.0 1.2 1 0 0 1 1 1 0 Sucrase/ferredoxin-like Ribosomal_L11_N PF03946.14 CCF38743.1 - 1.4e-25 88.9 0.1 1.5e-25 88.8 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Sec23_trunk PF04811.15 CCF38744.1 - 3e-79 266.0 0.0 4.1e-79 265.6 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 CCF38744.1 - 4.5e-31 107.5 0.3 9.3e-31 106.4 0.3 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 CCF38744.1 - 1.2e-25 89.3 0.1 4.5e-25 87.5 0.1 2.1 2 0 0 2 2 2 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 CCF38744.1 - 1.4e-15 57.1 5.7 2.5e-15 56.2 5.7 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 CCF38744.1 - 8.7e-12 44.8 0.0 2.6e-11 43.3 0.0 1.8 2 0 0 2 2 2 1 Gelsolin repeat Vps36-NZF-N PF16988.5 CCF38744.1 - 0.039 13.4 0.7 0.099 12.1 0.1 1.9 2 0 0 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain ArAE_2_N PF10337.9 CCF38745.1 - 1e-34 120.4 20.1 1.1e-27 97.3 0.1 3.8 3 1 1 4 4 4 3 Putative ER transporter, 6TM, N-terminal FUSC_2 PF13515.6 CCF38745.1 - 1e-10 41.8 14.4 1e-10 41.8 14.4 2.8 2 1 0 2 2 2 1 Fusaric acid resistance protein-like DUF2433 PF10360.9 CCF38745.1 - 0.093 12.8 0.3 0.24 11.5 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2433) Terminase_4 PF05119.12 CCF38745.1 - 0.14 12.7 2.0 6.7 7.2 0.0 2.7 2 0 0 2 2 2 0 Phage terminase, small subunit Wx5_PLAF3D7 PF09688.10 CCF38745.1 - 0.54 10.3 4.4 4.7 7.2 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (Wx5_PLAF3D7) Serglycin PF04360.12 CCF38745.1 - 4.8 7.1 6.5 3.3 7.7 3.9 1.9 2 0 0 2 2 2 0 Serglycin Trypan_PARP PF05887.11 CCF38745.1 - 8.5 6.4 15.1 5.5 7.0 12.0 2.2 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) SHR3_chaperone PF08229.11 CCF38746.1 - 0.00019 20.4 0.8 0.04 12.9 0.2 2.3 2 0 0 2 2 2 2 ER membrane protein SH3 DUF917 PF06032.12 CCF38747.1 - 8.5e-127 422.8 1.1 2.4e-126 421.3 0.2 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF917) Hydantoinase_A PF01968.18 CCF38747.1 - 1.2e-15 57.5 5.9 2.2e-15 56.7 3.0 2.2 1 1 1 2 2 2 1 Hydantoinase/oxoprolinase p450 PF00067.22 CCF38748.1 - 3.7e-48 164.4 0.0 4.7e-48 164.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 ILVD_EDD PF00920.21 CCF38750.1 - 4.9e-214 711.7 0.7 5.7e-214 711.5 0.7 1.0 1 0 0 1 1 1 1 Dehydratase family CLP_protease PF00574.23 CCF38751.1 - 4.9e-70 235.1 0.2 6.7e-70 234.7 0.2 1.1 1 0 0 1 1 1 1 Clp protease FMO-like PF00743.19 CCF38751.1 - 0.14 10.5 0.1 0.19 10.1 0.1 1.1 1 0 0 1 1 1 0 Flavin-binding monooxygenase-like MFS_1 PF07690.16 CCF38752.1 - 1.1e-26 93.7 50.4 3.5e-15 55.8 25.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 CCF38752.1 - 0.59 8.9 21.1 0.36 9.6 8.4 2.8 1 1 0 2 2 2 0 MFS_1 like family Actin PF00022.19 CCF38753.1 - 7.7e-71 238.8 0.0 5.4e-69 232.8 0.0 2.0 1 1 0 1 1 1 1 Actin F-box PF00646.33 CCF38754.1 - 2.5e-05 24.0 0.0 4.9e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 CCF38754.1 - 7.8e-05 22.5 0.0 0.00017 21.4 0.0 1.5 1 0 0 1 1 1 1 F-box-like PHD_Oberon PF07227.11 CCF38754.1 - 0.083 12.8 0.2 0.14 12.0 0.2 1.2 1 0 0 1 1 1 0 PHD - plant homeodomain finger protein PRANC PF09372.10 CCF38754.1 - 0.21 11.9 0.0 0.42 11.0 0.0 1.4 1 0 0 1 1 1 0 PRANC domain Histone PF00125.24 CCF38755.1 - 4.4e-17 62.7 0.0 5.8e-17 62.3 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 CCF38755.1 - 1.1e-12 47.4 0.8 1.9e-12 46.7 0.1 1.7 2 0 0 2 2 2 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.23 CCF38755.1 - 0.0001 22.5 0.0 0.00017 21.8 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Glyco_tranf_2_3 PF13641.6 CCF38756.1 - 1.8e-13 50.9 0.0 3e-13 50.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 CCF38756.1 - 9.6e-13 48.3 0.0 1.8e-12 47.4 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_trans_2_3 PF13632.6 CCF38756.1 - 3.1e-11 43.6 0.1 3.1e-11 43.6 0.1 2.5 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.6 CCF38756.1 - 5.6e-11 42.2 0.0 1e-10 41.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 Cellulose_synt PF03552.14 CCF38756.1 - 1e-05 24.3 7.3 0.0098 14.4 1.1 3.7 2 1 2 4 4 4 2 Cellulose synthase Dicty_CAR PF05462.11 CCF38756.1 - 2.4 7.2 9.6 0.11 11.6 0.5 2.5 3 0 0 3 3 3 0 Slime mold cyclic AMP receptor Anoctamin PF04547.12 CCF38756.1 - 8.6 5.1 7.7 1.1 8.1 0.1 2.5 3 0 0 3 3 3 0 Calcium-activated chloride channel TPT PF03151.16 CCF38757.1 - 2.1e-35 122.5 16.7 2.6e-35 122.2 16.7 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family UAA PF08449.11 CCF38757.1 - 0.0004 19.7 18.8 0.00077 18.8 18.8 1.5 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.20 CCF38757.1 - 0.018 15.2 33.6 0.2 11.9 14.4 2.5 2 1 0 2 2 2 0 EamA-like transporter family BTP PF05232.12 CCF38757.1 - 0.36 10.9 5.6 15 5.8 0.0 3.5 3 0 0 3 3 3 0 Chlorhexidine efflux transporter APH PF01636.23 CCF38759.1 - 1.7e-07 31.4 0.2 3.9e-07 30.3 0.2 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family SIR2 PF02146.17 CCF38761.1 - 7.3e-56 188.9 0.0 9.6e-56 188.5 0.0 1.2 1 0 0 1 1 1 1 Sir2 family DUF3107 PF11305.8 CCF38761.1 - 0.38 11.0 2.0 2.9 8.2 0.7 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3107) BAH PF01426.18 CCF38762.1 - 3.7e-18 65.5 0.1 1.5e-17 63.6 0.0 2.0 2 0 0 2 2 2 1 BAH domain ELM2 PF01448.24 CCF38762.1 - 0.11 13.2 5.9 1.5 9.6 5.9 3.1 1 1 0 1 1 1 0 ELM2 domain FYVE_2 PF02318.16 CCF38762.1 - 0.72 10.1 10.7 3.4 7.9 1.8 2.9 3 0 0 3 3 3 0 FYVE-type zinc finger Trypsin_2 PF13365.6 CCF38763.1 - 3.4e-11 44.2 1.3 7.8e-10 39.8 0.0 3.1 3 0 0 3 3 3 1 Trypsin-like peptidase domain Trypsin PF00089.26 CCF38763.1 - 2.7e-07 30.6 0.1 6.1e-07 29.5 0.1 1.5 1 0 0 1 1 1 1 Trypsin Peptidase_C3 PF00548.20 CCF38763.1 - 0.0018 18.3 0.7 0.0032 17.4 0.7 1.4 1 0 0 1 1 1 1 3C cysteine protease (picornain 3C) CorA PF01544.18 CCF38764.1 - 0.0009 18.6 4.8 0.0015 17.9 4.8 1.5 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein RNA_pol_L_2 PF13656.6 CCF38765.1 - 6.1e-29 99.6 0.0 7.7e-29 99.3 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 CCF38765.1 - 9.2e-11 41.0 0.0 1.3e-10 40.5 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Glyco_hydro_47 PF01532.20 CCF38767.1 - 6.5e-169 562.7 0.0 7.6e-169 562.4 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Sugar_tr PF00083.24 CCF38768.1 - 0.0044 15.9 0.2 0.0051 15.7 0.2 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter Shikimate_dh_N PF08501.11 CCF38769.1 - 3.8e-21 75.1 0.0 8e-21 74.1 0.0 1.6 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain SDH_C PF18317.1 CCF38769.1 - 6.1e-07 29.1 0.1 1.2e-06 28.1 0.1 1.5 1 0 0 1 1 1 1 Shikimate 5'-dehydrogenase C-terminal domain Shikimate_DH PF01488.20 CCF38769.1 - 0.05 13.7 0.0 0.092 12.8 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase COX16 PF14138.6 CCF38771.1 - 3.7e-34 117.1 0.3 5e-34 116.7 0.3 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein COX16 zf-P11 PF03854.14 CCF38772.1 - 0.005 16.5 3.0 0.0077 15.9 3.0 1.3 1 0 0 1 1 1 1 P-11 zinc finger Tho2 PF11262.8 CCF38778.1 - 2.3e-80 270.0 0.0 3.1e-80 269.6 0.0 1.2 1 0 0 1 1 1 1 Transcription factor/nuclear export subunit protein 2 SAM_2 PF07647.17 CCF38779.1 - 1.7e-09 37.7 0.1 2.8e-09 37.0 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 CCF38779.1 - 3.1e-05 24.3 0.3 5.6e-05 23.5 0.3 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) IGR PF09597.10 CCF38779.1 - 0.019 15.1 0.4 0.05 13.7 0.2 1.7 2 0 0 2 2 2 0 IGR protein motif TPR_MLP1_2 PF07926.12 CCF38780.1 - 1.8e-39 134.8 31.6 1.8e-39 134.8 31.6 12.5 6 3 5 11 11 10 4 TPR/MLP1/MLP2-like protein ZapB PF06005.12 CCF38780.1 - 0.0019 18.6 6.7 0.0019 18.6 6.7 18.0 7 6 5 13 13 12 1 Cell division protein ZapB DUF5082 PF16888.5 CCF38780.1 - 0.0068 16.7 2.3 0.0068 16.7 2.3 12.1 6 3 5 13 13 10 3 Domain of unknown function (DUF5082) JIP_LZII PF16471.5 CCF38780.1 - 0.0099 16.0 6.6 0.026 14.7 1.2 17.0 13 5 3 18 18 16 4 JNK-interacting protein leucine zipper II FlaC_arch PF05377.11 CCF38780.1 - 0.011 16.2 1.1 0.011 16.2 1.1 14.3 13 3 1 14 14 13 0 Flagella accessory protein C (FlaC) BST2 PF16716.5 CCF38780.1 - 0.011 16.2 3.2 0.011 16.2 3.2 14.0 6 5 9 15 15 12 0 Bone marrow stromal antigen 2 Fez1 PF06818.15 CCF38780.1 - 0.033 14.6 160.0 0.087 13.3 6.8 8.4 1 1 6 8 8 8 0 Fez1 CBP_BcsF PF11120.8 CCF38780.1 - 0.072 13.2 1.5 0.2 11.8 0.5 2.1 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsF Halo_GVPC PF05465.13 CCF38780.1 - 0.51 10.6 4.2 7.5 6.9 0.0 4.3 3 0 0 3 3 3 0 Halobacterial gas vesicle protein C (GVPC) repeat Surfac_D-trimer PF09006.11 CCF38780.1 - 3.9 7.4 5.0 29 4.7 0.0 3.9 4 0 0 4 4 3 0 Lung surfactant protein D coiled-coil trimerisation Cation_ATPase PF13246.6 CCF38780.1 - 4.3 7.5 7.4 9.8 6.3 0.4 3.8 2 1 1 3 3 3 0 Cation transport ATPase (P-type) Glyco_hydro_47 PF01532.20 CCF38781.1 - 6.4e-117 391.2 0.0 8.3e-117 390.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 FAA_hydrolase PF01557.18 CCF38782.1 - 7.5e-64 215.4 0.0 1.1e-63 214.8 0.0 1.3 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Abhydrolase_1 PF00561.20 CCF38782.1 - 8.9e-24 84.5 0.0 4.1e-15 56.1 0.0 2.2 1 1 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCF38782.1 - 1.5e-18 68.3 1.2 2.4e-18 67.5 1.2 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCF38782.1 - 6e-17 61.7 0.0 2e-16 60.0 0.0 1.7 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Ser_hydrolase PF06821.13 CCF38782.1 - 8.8e-09 35.4 0.0 5.7e-06 26.3 0.0 2.6 1 1 0 1 1 1 1 Serine hydrolase Esterase PF00756.20 CCF38782.1 - 0.01 15.5 0.0 0.017 14.8 0.0 1.3 1 0 0 1 1 1 0 Putative esterase Abhydrolase_4 PF08386.10 CCF38782.1 - 0.021 14.9 0.0 0.051 13.7 0.0 1.7 1 0 0 1 1 1 0 TAP-like protein LCAT PF02450.15 CCF38782.1 - 0.047 12.9 0.0 0.082 12.1 0.0 1.3 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase LIDHydrolase PF10230.9 CCF38782.1 - 0.054 13.0 0.0 0.092 12.3 0.0 1.3 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase AA_permease PF00324.21 CCF38784.1 - 9.1e-125 416.9 41.0 1.1e-124 416.7 41.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CCF38784.1 - 6.9e-29 100.9 45.9 9.6e-29 100.5 45.9 1.1 1 0 0 1 1 1 1 Amino acid permease DUF3580 PF12117.8 CCF38785.1 - 0.052 13.8 0.1 0.061 13.6 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3580) AMP-binding PF00501.28 CCF38786.1 - 6.6e-72 242.4 0.0 7.9e-72 242.1 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CCF38786.1 - 1.4e-09 38.8 0.2 3.2e-09 37.6 0.2 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain GH3 PF03321.13 CCF38786.1 - 0.26 10.1 0.0 6.6 5.5 0.0 2.1 2 0 0 2 2 2 0 GH3 auxin-responsive promoter Fungal_trans_2 PF11951.8 CCF38788.1 - 6.2e-08 31.9 0.0 8.7e-08 31.4 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain FMO-like PF00743.19 CCF38789.1 - 4.9e-25 88.0 0.0 2.8e-21 75.6 0.0 2.5 2 1 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 CCF38789.1 - 3.9e-11 42.7 0.0 5.8e-10 38.9 0.0 2.5 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CCF38789.1 - 7.6e-10 38.5 0.0 1.6e-09 37.4 0.0 1.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CCF38789.1 - 3e-08 33.2 0.1 8.3e-06 25.2 0.0 3.2 2 1 1 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 CCF38789.1 - 7.3e-08 32.5 0.0 3e-07 30.6 0.0 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 CCF38789.1 - 7.1e-06 26.1 0.0 0.0001 22.3 0.0 2.7 2 1 0 2 2 2 1 FAD-NAD(P)-binding DAO PF01266.24 CCF38789.1 - 0.00041 20.0 0.0 0.0018 17.9 0.0 1.8 2 1 1 3 3 3 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 CCF38789.1 - 0.00043 20.8 0.6 0.63 10.6 0.1 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CCF38789.1 - 0.0035 16.6 0.1 0.0075 15.5 0.0 1.5 2 0 0 2 2 2 1 Thi4 family Shikimate_DH PF01488.20 CCF38789.1 - 0.032 14.3 0.1 5.6 7.0 0.0 2.3 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase HI0933_like PF03486.14 CCF38789.1 - 0.15 10.8 0.1 0.34 9.6 0.0 1.6 2 0 0 2 2 2 0 HI0933-like protein NmrA PF05368.13 CCF38790.1 - 7.6e-12 45.3 0.0 9e-12 45.0 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CCF38790.1 - 9.9e-11 41.9 0.0 1.4e-10 41.3 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Gcd10p PF04189.13 CCF38791.1 - 6.5e-125 416.2 0.0 8e-125 415.9 0.0 1.1 1 0 0 1 1 1 1 Gcd10p family FeoB_Cyto PF17910.1 CCF38791.1 - 0.0042 17.6 0.0 0.023 15.3 0.0 2.2 1 1 0 1 1 1 1 FeoB cytosolic helical domain P21-Arc PF04062.14 CCF38792.1 - 2.2e-71 239.5 0.0 2.5e-71 239.3 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex ARPC3 (21 kDa) subunit zf-C2H2 PF00096.26 CCF38794.1 - 3.6 8.2 11.2 6.7 7.4 0.2 3.0 2 1 0 2 2 2 0 Zinc finger, C2H2 type Kinesin PF00225.23 CCF38795.1 - 3.4e-94 315.5 0.0 2.2e-93 312.8 0.0 2.5 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 CCF38795.1 - 1.7e-18 67.0 0.0 2.7e-15 56.6 0.0 3.2 2 0 0 2 2 2 2 Microtubule binding HisKA PF00512.25 CCF38795.1 - 3.1 7.9 10.7 3.4 7.8 2.1 4.1 3 0 0 3 3 3 0 His Kinase A (phospho-acceptor) domain AlkA_N PF06029.11 CCF38795.1 - 3.7 7.9 6.9 2.8 8.2 0.5 3.6 3 0 0 3 3 3 0 AlkA N-terminal domain PhoLip_ATPase_N PF16209.5 CCF38796.1 - 1.4e-18 66.4 0.0 2.9e-18 65.3 0.0 1.5 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.20 CCF38796.1 - 1.9e-11 43.8 0.0 4e-11 42.8 0.0 1.5 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase PF13246.6 CCF38796.1 - 2.9e-10 40.1 0.0 6.6e-10 39.0 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) CDC50 PF03381.15 CCF38797.1 - 4.4e-51 174.1 0.0 5.3e-51 173.8 0.0 1.0 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family DUF3285 PF11688.8 CCF38797.1 - 0.019 14.9 0.2 0.035 14.0 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3285) Lipase_GDSL_2 PF13472.6 CCF38798.1 - 2.1e-12 47.8 0.2 2.8e-12 47.4 0.2 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 CCF38798.1 - 1.3e-05 25.3 0.0 1.8e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Gloverin PF10793.9 CCF38798.1 - 0.062 13.2 0.4 2.2 8.1 0.0 2.2 2 0 0 2 2 2 0 Gloverin-like protein ALGX PF16822.5 CCF38798.1 - 0.097 12.3 0.3 0.21 11.3 0.3 1.5 1 0 0 1 1 1 0 SGNH hydrolase-like domain, acetyltransferase AlgX ABC_tran PF00005.27 CCF38800.1 - 4.1e-33 114.8 0.0 2.9e-15 57.0 0.0 2.5 2 0 0 2 2 2 2 ABC transporter RLI PF04068.15 CCF38800.1 - 9.6e-14 50.9 5.3 9.6e-14 50.9 5.3 2.0 2 0 0 2 2 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI SMC_N PF02463.19 CCF38800.1 - 4.8e-12 45.8 0.5 0.00016 21.2 0.0 3.4 2 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 CCF38800.1 - 6.5e-09 36.0 7.5 0.24 11.1 1.8 4.6 3 2 2 5 5 4 4 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 CCF38800.1 - 7.3e-06 26.5 0.0 0.027 14.9 0.0 2.5 3 0 0 3 3 2 2 AAA ATPase domain AAA_22 PF13401.6 CCF38800.1 - 1.5e-05 25.3 0.0 0.0034 17.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 CCF38800.1 - 1.6e-05 25.4 0.1 0.016 15.7 0.1 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_15 PF13175.6 CCF38800.1 - 1.8e-05 24.6 0.4 0.14 11.8 0.0 3.1 2 1 0 3 3 3 2 AAA ATPase domain AAA_23 PF13476.6 CCF38800.1 - 6.2e-05 23.6 0.0 0.018 15.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain Fer4 PF00037.27 CCF38800.1 - 0.00011 21.8 1.3 0.00011 21.8 1.3 2.7 3 0 0 3 3 3 1 4Fe-4S binding domain RsgA_GTPase PF03193.16 CCF38800.1 - 0.00012 22.1 0.0 0.43 10.5 0.0 2.8 3 0 0 3 3 2 2 RsgA GTPase Fer4_10 PF13237.6 CCF38800.1 - 0.00022 21.3 8.3 0.01 15.9 0.1 2.4 2 0 0 2 2 2 1 4Fe-4S dicluster domain AAA_29 PF13555.6 CCF38800.1 - 0.00025 20.7 0.3 0.49 10.2 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain Rad17 PF03215.15 CCF38800.1 - 0.0003 20.8 0.1 0.05 13.5 0.0 2.6 2 1 0 2 2 2 1 Rad17 P-loop domain AAA_18 PF13238.6 CCF38800.1 - 0.00049 20.6 0.1 1.7 9.2 0.0 2.8 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 CCF38800.1 - 0.00065 20.1 0.1 0.36 11.2 0.0 2.8 2 0 0 2 2 2 1 RNA helicase AAA_24 PF13479.6 CCF38800.1 - 0.0022 17.7 2.1 0.22 11.2 0.1 2.7 2 1 0 2 2 2 1 AAA domain Fer4_21 PF14697.6 CCF38800.1 - 0.0023 18.0 10.4 0.0047 17.0 10.4 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain AAA_33 PF13671.6 CCF38800.1 - 0.0028 17.8 0.0 0.5 10.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 CCF38800.1 - 0.0029 17.5 1.3 0.27 11.1 0.0 2.5 2 0 0 2 2 2 1 NACHT domain SRP54 PF00448.22 CCF38800.1 - 0.0033 17.1 3.0 0.098 12.3 0.1 2.3 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_13 PF13166.6 CCF38800.1 - 0.0039 15.9 0.0 0.0039 15.9 0.0 1.9 3 0 0 3 3 2 1 AAA domain TsaE PF02367.17 CCF38800.1 - 0.0049 16.9 0.1 0.049 13.6 0.0 2.2 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_5 PF07728.14 CCF38800.1 - 0.0061 16.6 0.2 0.3 11.1 0.0 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Thymidylate_kin PF02223.17 CCF38800.1 - 0.0073 16.0 0.4 2.3 7.9 0.0 2.8 3 0 0 3 3 3 1 Thymidylate kinase Fer4_6 PF12837.7 CCF38800.1 - 0.0087 16.1 11.4 0.019 15.0 1.1 2.5 2 0 0 2 2 2 1 4Fe-4S binding domain AAA_28 PF13521.6 CCF38800.1 - 0.011 16.0 0.3 1.5 9.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 CCF38800.1 - 0.012 15.2 0.2 0.22 11.0 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region NB-ARC PF00931.22 CCF38800.1 - 0.012 14.8 0.0 0.88 8.7 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain Fer4_7 PF12838.7 CCF38800.1 - 0.014 16.0 7.4 0.015 15.9 0.3 2.5 2 0 0 2 2 2 0 4Fe-4S dicluster domain Fer4_9 PF13187.6 CCF38800.1 - 0.061 13.5 10.5 0.13 12.4 10.5 1.6 1 0 0 1 1 1 0 4Fe-4S dicluster domain AAA_30 PF13604.6 CCF38800.1 - 0.063 13.0 0.2 3.8 7.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain Fer4_16 PF13484.6 CCF38800.1 - 0.08 13.9 0.3 0.08 13.9 0.3 2.7 2 0 0 2 2 2 0 4Fe-4S double cluster binding domain MMR_HSR1 PF01926.23 CCF38800.1 - 0.12 12.4 0.9 18 5.4 0.0 2.7 2 1 0 2 2 2 0 50S ribosome-binding GTPase VirE PF05272.11 CCF38800.1 - 0.13 11.9 0.0 7.6 6.2 0.0 2.4 2 0 0 2 2 2 0 Virulence-associated protein E ATPase PF06745.13 CCF38800.1 - 0.15 11.3 0.0 0.42 9.9 0.0 1.7 1 0 0 1 1 1 0 KaiC TniB PF05621.11 CCF38800.1 - 0.18 11.2 0.1 1.3 8.4 0.0 2.3 2 0 0 2 2 2 0 Bacterial TniB protein PduV-EutP PF10662.9 CCF38800.1 - 0.21 11.3 3.4 0.62 9.8 0.0 2.8 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation NTPase_1 PF03266.15 CCF38800.1 - 0.27 11.2 1.6 6.7 6.6 0.1 2.5 2 0 0 2 2 2 0 NTPase CLP1_P PF16575.5 CCF38800.1 - 0.36 10.6 1.0 1.5 8.5 0.0 2.2 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop Fer4_2 PF12797.7 CCF38800.1 - 3.7 7.8 10.2 0.48 10.6 1.1 2.6 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_8 PF13183.6 CCF38800.1 - 7.7 7.1 11.7 0.64 10.5 1.6 2.4 1 1 1 2 2 2 0 4Fe-4S dicluster domain p450 PF00067.22 CCF38804.1 - 2.4e-70 237.6 0.0 3.6e-70 237.0 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 Flavodoxin_1 PF00258.25 CCF38804.1 - 2.8e-19 69.7 0.0 5.5e-19 68.8 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin FAD_binding_1 PF00667.20 CCF38804.1 - 3.2e-14 53.1 0.0 6.3e-14 52.1 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 CCF38804.1 - 6.6e-07 30.0 0.0 1.8e-06 28.5 0.0 1.8 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 CCF38804.1 - 0.0021 18.2 0.0 0.0048 17.0 0.0 1.5 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_6 PF00970.24 CCF38804.1 - 0.057 13.8 0.0 0.2 12.0 0.0 1.9 2 0 0 2 2 2 0 Oxidoreductase FAD-binding domain PrmA PF06325.13 CCF38804.1 - 0.16 11.3 0.0 0.3 10.4 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) RasGAP PF00616.19 CCF38806.1 - 9.6e-30 103.8 0.0 6e-21 75.1 0.0 2.5 1 1 1 2 2 2 2 GTPase-activator protein for Ras-like GTPase C2 PF00168.30 CCF38806.1 - 0.0012 19.1 0.0 0.0026 18.0 0.0 1.6 1 0 0 1 1 1 1 C2 domain HET PF06985.11 CCF38807.1 - 1.6e-13 51.2 3.0 1.4e-10 41.7 0.2 2.5 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) MFS_1 PF07690.16 CCF38808.1 - 2.8e-08 33.1 8.3 1.1e-07 31.1 8.1 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily ketoacyl-synt PF00109.26 CCF38809.1 - 5.8e-74 248.9 0.0 1.1e-73 248.0 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain PS-DH PF14765.6 CCF38809.1 - 3.4e-55 187.4 0.0 7.4e-55 186.3 0.0 1.5 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 CCF38809.1 - 7.8e-40 137.3 0.1 1.6e-39 136.3 0.1 1.5 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 CCF38809.1 - 1.8e-35 121.5 0.0 4.9e-35 120.1 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Methyltransf_12 PF08242.12 CCF38809.1 - 4.2e-19 69.1 0.0 9.5e-19 68.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain KAsynt_C_assoc PF16197.5 CCF38809.1 - 7.7e-15 55.3 0.0 1.8e-14 54.1 0.0 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Methyltransf_25 PF13649.6 CCF38809.1 - 3e-11 43.9 0.0 1.1e-10 42.1 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF38809.1 - 1.1e-10 41.6 0.0 2.5e-10 40.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF38809.1 - 2e-08 34.8 0.0 5.1e-08 33.5 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Thiolase_N PF00108.23 CCF38809.1 - 7.4e-07 28.8 0.0 1.5e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain Methyltransf_31 PF13847.6 CCF38809.1 - 6.5e-06 26.0 0.0 1.6e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCF38809.1 - 9.3e-06 25.1 0.0 1.8e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family NodS PF05401.11 CCF38809.1 - 0.0023 17.6 0.0 0.0043 16.7 0.0 1.3 1 0 0 1 1 1 1 Nodulation protein S (NodS) ACP_syn_III PF08545.10 CCF38809.1 - 0.005 16.7 0.4 0.017 14.9 0.4 2.0 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Methyltransf_2 PF00891.18 CCF38809.1 - 0.0099 15.2 0.0 0.027 13.8 0.0 1.7 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_8 PF05148.15 CCF38809.1 - 0.084 12.7 0.0 0.22 11.3 0.0 1.6 1 0 0 1 1 1 0 Hypothetical methyltransferase Beta-lactamase PF00144.24 CCF38810.1 - 1.5e-49 169.0 0.0 1.8e-49 168.8 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase Peptidase_S13 PF02113.15 CCF38810.1 - 0.17 10.5 0.0 0.3 9.8 0.0 1.3 1 0 0 1 1 1 0 D-Ala-D-Ala carboxypeptidase 3 (S13) family p450 PF00067.22 CCF38811.1 - 1.2e-35 123.2 0.0 1.9e-35 122.5 0.0 1.3 1 0 0 1 1 1 1 Cytochrome P450 B12D PF06522.11 CCF38811.1 - 0.1 12.4 0.8 0.6 9.9 0.2 2.4 2 0 0 2 2 2 0 NADH-ubiquinone reductase complex 1 MLRQ subunit ketoacyl-synt PF00109.26 CCF38812.1 - 4.1e-78 262.5 0.2 6.5e-78 261.8 0.1 1.4 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 CCF38812.1 - 8.9e-34 116.0 0.0 1.7e-33 115.1 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 CCF38812.1 - 7.8e-10 39.2 0.0 1.8e-09 38.1 0.0 1.6 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Thiolase_N PF00108.23 CCF38812.1 - 5e-07 29.3 0.1 1e-06 28.3 0.1 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain ACP_syn_III PF08545.10 CCF38812.1 - 0.056 13.3 0.9 0.63 9.9 0.7 2.4 1 1 1 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Glutaredoxin PF00462.24 CCF38813.1 - 9.7e-16 57.7 0.0 2.2e-15 56.6 0.0 1.6 1 0 0 1 1 1 1 Glutaredoxin G_glu_transpept PF01019.21 CCF38814.1 - 1.8e-125 419.6 0.0 4e-125 418.5 0.0 1.5 1 1 0 1 1 1 1 Gamma-glutamyltranspeptidase Agouti PF05039.12 CCF38815.1 - 0.54 11.0 1.6 0.83 10.4 0.1 2.0 2 0 0 2 2 2 0 Agouti protein bZIP_2 PF07716.15 CCF38816.1 - 2.3e-05 24.4 7.2 4.1e-05 23.6 7.2 1.3 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 CCF38816.1 - 3.6e-05 23.8 5.6 5.9e-05 23.1 5.6 1.2 1 0 0 1 1 1 1 bZIP transcription factor TTKRSYEDQ PF10212.9 CCF38816.1 - 0.016 14.2 0.1 0.022 13.8 0.1 1.1 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein Fes1 PF08609.10 CCF38816.1 - 0.12 13.2 0.4 0.3 12.0 0.4 1.7 1 1 0 1 1 1 0 Nucleotide exchange factor Fes1 DUF5451 PF17532.2 CCF38816.1 - 0.13 12.5 1.1 0.25 11.6 0.8 1.5 1 1 0 1 1 1 0 Family of unknown function (DUF5451) BolA PF01722.18 CCF38820.1 - 1.8e-29 101.9 1.9 2.2e-29 101.5 1.9 1.1 1 0 0 1 1 1 1 BolA-like protein DNA_gyraseB PF00204.25 CCF38823.1 - 0.019 14.5 0.5 0.019 14.4 0.5 1.1 1 0 0 1 1 1 0 DNA gyrase B ADH_zinc_N PF00107.26 CCF38825.1 - 4.6e-30 104.3 0.7 4.6e-30 104.3 0.7 1.5 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCF38825.1 - 1e-20 75.1 0.1 2.7e-20 73.8 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCF38825.1 - 2.1e-08 34.0 0.0 5.3e-08 32.7 0.0 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain TrkA_N PF02254.18 CCF38825.1 - 0.00034 20.8 0.0 0.0006 20.1 0.0 1.4 1 0 0 1 1 1 1 TrkA-N domain Collagen PF01391.18 CCF38827.1 - 0.03 14.1 4.9 0.045 13.5 4.9 1.3 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) Clr5 PF14420.6 CCF38828.1 - 6.2e-13 48.8 3.5 1.2e-12 47.8 3.5 1.6 1 1 0 1 1 1 1 Clr5 domain zf-Nse PF11789.8 CCF38831.1 - 7.5e-05 22.5 0.0 0.00014 21.6 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit PBP1_TM PF14812.6 CCF38831.1 - 6.7 7.2 10.7 2.5 8.5 5.6 2.3 2 1 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Hexokinase_2 PF03727.16 CCF38832.1 - 2.2e-55 187.7 0.0 2.8e-55 187.3 0.0 1.1 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 CCF38832.1 - 1.4e-38 132.8 0.0 2.1e-38 132.2 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Glucosamine_iso PF01182.20 CCF38833.1 - 2.1e-20 73.6 0.0 3.6e-20 72.8 0.0 1.3 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase NDT80_PhoG PF05224.12 CCF38834.1 - 2.4e-33 115.9 0.0 5.1e-33 114.9 0.0 1.5 2 0 0 2 2 2 1 NDT80 / PhoG like DNA-binding family Amidohydro_1 PF01979.20 CCF38835.1 - 2.2e-16 60.1 0.0 3.4e-16 59.5 0.0 1.3 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 CCF38835.1 - 3.6e-11 43.2 0.4 4.9e-09 36.2 0.3 2.2 2 0 0 2 2 2 2 Amidohydrolase family Glyco_hydro_3 PF00933.21 CCF38836.1 - 2.4e-10 40.3 0.0 2.8e-10 40.1 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Sof1 PF04158.14 CCF38836.1 - 0.14 12.5 0.0 0.18 12.1 0.0 1.1 1 0 0 1 1 1 0 Sof1-like domain CsiD PF08943.10 CCF38836.1 - 0.17 11.0 0.0 0.18 10.8 0.0 1.1 1 0 0 1 1 1 0 CsiD zf-B_box PF00643.24 CCF38837.1 - 0.011 15.9 3.7 0.02 15.0 3.7 1.4 1 0 0 1 1 1 0 B-box zinc finger CEBP_ZZ PF16366.5 CCF38837.1 - 0.31 11.3 5.1 0.56 10.5 5.1 1.4 1 0 0 1 1 1 0 Cytoplasmic polyadenylation element-binding protein ZZ domain Wzy_C PF04932.15 CCF38838.1 - 3.1 7.4 14.7 16 5.1 11.2 2.6 2 1 0 2 2 2 0 O-Antigen ligase Pkinase PF00069.25 CCF38839.1 - 2.9e-26 92.4 0.0 3.8e-26 92.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF38839.1 - 8.5e-14 51.5 0.0 1.2e-13 51.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CCF38839.1 - 5.3e-09 35.3 0.5 7.4e-09 34.9 0.0 1.4 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 CCF38839.1 - 0.00021 21.3 0.0 0.0016 18.4 0.0 2.1 1 1 0 2 2 2 1 Phosphotransferase enzyme family p450 PF00067.22 CCF38840.1 - 5.7e-12 45.1 0.0 6.4e-12 45.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Pkinase PF00069.25 CCF38842.1 - 3.2e-45 154.5 0.0 4.3e-45 154.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF38842.1 - 1.4e-16 60.6 0.0 1.8e-16 60.2 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 CCF38842.1 - 0.00012 21.2 0.0 0.00017 20.7 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 CCF38842.1 - 0.0013 18.7 0.0 0.0022 18.0 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 CCF38842.1 - 0.033 13.5 0.0 0.051 12.9 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Sugar_tr PF00083.24 CCF38843.1 - 5.7e-30 104.6 12.3 6.8e-30 104.3 12.3 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF38843.1 - 2.8e-09 36.4 13.7 3.6e-09 36.0 13.7 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_1_like PF12832.7 CCF38843.1 - 4e-07 29.2 2.9 4.7e-07 29.0 2.9 1.1 1 0 0 1 1 1 1 MFS_1 like family UNC-93 PF05978.16 CCF38843.1 - 2.8 7.6 9.6 0.066 12.9 3.0 1.5 2 0 0 2 2 2 0 Ion channel regulatory protein UNC-93 SelP_N PF04592.14 CCF38844.1 - 0.03 13.7 8.3 0.051 13.0 8.3 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region SMC_Nse1 PF07574.13 CCF38844.1 - 0.043 13.7 0.0 0.063 13.2 0.0 1.2 1 0 0 1 1 1 0 Nse1 non-SMC component of SMC5-6 complex YCII PF03795.14 CCF38845.1 - 9.5e-10 38.8 0.0 1.3e-09 38.3 0.0 1.1 1 0 0 1 1 1 1 YCII-related domain Pkinase PF00069.25 CCF38846.1 - 1.1e-19 70.8 0.0 3e-19 69.4 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF38846.1 - 1.1e-10 41.2 0.0 4.3e-10 39.3 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CCF38846.1 - 0.0061 15.9 0.0 0.0095 15.3 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CCF38846.1 - 0.054 13.4 0.1 0.082 12.8 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.6 CCF38846.1 - 0.069 12.4 0.0 0.16 11.3 0.0 1.5 2 0 0 2 2 2 0 Kinase-like Apt1 PF10351.9 CCF38848.1 - 0.017 14.0 5.3 0.022 13.6 5.3 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF4614 PF15391.6 CCF38848.1 - 1.8 8.6 17.9 3.2 7.7 17.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) PH_12 PF16457.5 CCF38848.1 - 3.2 8.3 6.2 5.3 7.6 6.2 1.3 1 0 0 1 1 1 0 Pleckstrin homology domain Sec3_C PF09763.9 CCF38848.1 - 3.9 5.8 6.9 5.2 5.3 6.9 1.1 1 0 0 1 1 1 0 Exocyst complex component Sec3 Macoilin PF09726.9 CCF38848.1 - 7.2 5.0 12.3 11 4.5 12.3 1.1 1 0 0 1 1 1 0 Macoilin family DUF4834 PF16118.5 CCF38848.1 - 7.4 7.6 5.0 15 6.6 3.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) CENP-I PF07778.11 CCF38849.1 - 6.3e-14 51.6 0.0 8.8e-14 51.1 0.0 1.1 1 0 0 1 1 1 1 Mis6 PKHD_C PF18331.1 CCF38849.1 - 0.062 13.4 0.0 0.14 12.2 0.0 1.6 1 0 0 1 1 1 0 PKHD-type hydroxylase C-terminal domain ABC_tran PF00005.27 CCF38850.1 - 6.5e-16 59.1 0.6 6.4e-15 55.9 0.1 2.4 2 1 0 2 2 1 1 ABC transporter AAA_21 PF13304.6 CCF38850.1 - 1e-11 45.2 0.5 0.00013 21.9 0.2 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system DUF3584 PF12128.8 CCF38850.1 - 0.0018 15.9 0.2 0.0023 15.5 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) SMC_N PF02463.19 CCF38850.1 - 0.0034 16.8 0.0 2.2 7.6 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CCF38850.1 - 0.0035 17.0 0.4 0.0035 17.0 0.4 1.9 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_23 PF13476.6 CCF38850.1 - 0.0043 17.6 0.2 0.006 17.1 0.2 1.2 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 CCF38850.1 - 0.016 15.4 0.4 0.033 14.5 0.4 1.5 1 0 0 1 1 1 0 AAA domain AAA_15 PF13175.6 CCF38850.1 - 0.017 14.9 0.1 0.022 14.5 0.1 1.1 1 0 0 1 1 1 0 AAA ATPase domain AAA_16 PF13191.6 CCF38850.1 - 0.018 15.4 0.7 0.029 14.7 0.7 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 CCF38850.1 - 0.034 14.4 0.5 0.16 12.2 0.0 2.2 3 0 0 3 3 3 0 AAA domain PduV-EutP PF10662.9 CCF38850.1 - 0.034 13.9 0.1 0.054 13.2 0.1 1.3 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_25 PF13481.6 CCF38850.1 - 0.038 13.6 0.0 0.075 12.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain SRP54 PF00448.22 CCF38850.1 - 0.038 13.6 0.1 0.061 12.9 0.1 1.4 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain RsgA_GTPase PF03193.16 CCF38850.1 - 0.039 13.9 0.1 0.068 13.1 0.1 1.3 1 0 0 1 1 1 0 RsgA GTPase Arf PF00025.21 CCF38850.1 - 0.065 12.7 0.3 0.16 11.4 0.3 1.7 1 1 0 1 1 1 0 ADP-ribosylation factor family AAA PF00004.29 CCF38850.1 - 0.12 12.8 0.2 0.36 11.3 0.2 2.0 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Roc PF08477.13 CCF38850.1 - 0.14 12.4 0.1 0.78 10.0 0.0 2.0 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_13 PF13166.6 CCF38850.1 - 0.14 10.7 0.1 0.2 10.3 0.1 1.1 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 CCF38850.1 - 0.16 12.1 0.1 0.31 11.2 0.1 1.4 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 CCF38850.1 - 0.18 11.7 0.1 0.29 11.0 0.1 1.3 1 0 0 1 1 1 0 NACHT domain Glyco_transf_15 PF01793.16 CCF38851.1 - 1.9e-51 175.2 1.0 1.6e-34 119.7 0.2 3.0 2 1 0 2 2 2 2 Glycolipid 2-alpha-mannosyltransferase BTB PF00651.31 CCF38852.1 - 9e-05 22.7 0.0 0.00027 21.1 0.0 1.8 1 1 0 1 1 1 1 BTB/POZ domain Cyclin PF08613.11 CCF38853.1 - 2.5e-42 145.0 0.0 4e-42 144.3 0.0 1.3 1 0 0 1 1 1 1 Cyclin Pex14_N PF04695.13 CCF38853.1 - 0.0052 17.5 1.2 0.0052 17.5 1.2 2.0 2 0 0 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region COesterase PF00135.28 CCF38854.1 - 3.4e-93 313.3 0.0 4.2e-93 312.9 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CCF38854.1 - 0.0032 17.4 0.1 0.028 14.3 0.1 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold DNA_primase_S PF01896.19 CCF38855.1 - 0.12 12.4 0.0 0.2 11.7 0.0 1.3 1 0 0 1 1 1 0 DNA primase small subunit DUF3537 PF12056.8 CCF38857.1 - 8.4 5.1 6.9 18 4.0 6.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3537) La PF05383.17 CCF38858.1 - 0.0044 17.0 0.0 0.0074 16.3 0.0 1.3 1 0 0 1 1 1 1 La domain Got1 PF04178.12 CCF38860.1 - 8e-34 116.5 16.1 1.1e-33 116.1 16.1 1.1 1 0 0 1 1 1 1 Got1/Sft2-like family DUF2070 PF09843.9 CCF38860.1 - 3.1 6.0 5.6 3.8 5.7 5.6 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) ATP12 PF07542.11 CCF38862.1 - 6.4e-06 26.3 0.0 1.4e-05 25.1 0.0 1.6 1 0 0 1 1 1 1 ATP12 chaperone protein Fungal_trans PF04082.18 CCF38865.1 - 1e-09 37.8 0.1 4.7e-09 35.7 0.0 2.0 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF38865.1 - 2.5e-08 33.9 9.1 4.4e-08 33.1 9.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SOG2 PF10428.9 CCF38865.1 - 0.099 11.8 0.3 0.17 11.1 0.3 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein CwfJ_C_1 PF04677.15 CCF38866.1 - 6.3e-24 84.2 0.0 1.2e-23 83.3 0.0 1.3 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.14 CCF38866.1 - 2.9e-13 50.5 0.6 6.9e-13 49.3 0.6 1.6 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 ISN1 PF06437.11 CCF38867.1 - 0.089 11.7 0.0 0.15 10.9 0.0 1.3 1 0 0 1 1 1 0 IMP-specific 5'-nucleotidase DUF3818 PF12825.7 CCF38868.1 - 4.9e-60 203.4 0.2 1.4e-34 119.6 0.1 2.1 1 1 1 2 2 2 2 Domain of unknown function in PX-proteins (DUF3818) PXB PF12828.7 CCF38868.1 - 7.7e-41 139.1 0.0 1.3e-40 138.4 0.0 1.4 1 0 0 1 1 1 1 PX-associated Peptidase_C48 PF02902.19 CCF38869.1 - 1.3e-14 54.6 0.0 4.1e-14 52.9 0.0 1.8 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain AIG2_2 PF13772.6 CCF38870.1 - 3.8e-06 27.2 0.0 6.5e-05 23.2 0.0 2.2 2 0 0 2 2 2 1 AIG2-like family Zn_clus PF00172.18 CCF38871.1 - 2.6e-09 37.0 7.9 2.6e-09 37.0 7.9 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-CCCH PF00642.24 CCF38872.1 - 5.4e-11 42.1 8.6 1.5e-05 24.8 2.1 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 CCF38872.1 - 1.4e-10 40.7 11.8 2.6e-05 23.9 3.5 2.6 2 0 0 2 2 2 2 CCCH-type zinc finger zf_CCCH_4 PF18345.1 CCF38872.1 - 3.9e-10 39.5 17.4 6.9e-05 22.8 4.2 2.4 2 0 0 2 2 2 2 Zinc finger domain Torus PF16131.5 CCF38872.1 - 9.3e-09 36.0 6.2 0.00011 22.9 0.5 2.4 1 1 1 2 2 2 2 Torus domain zf-CCCH_3 PF15663.5 CCF38872.1 - 4.4e-05 23.6 1.1 8.8e-05 22.7 1.1 1.4 1 0 0 1 1 1 1 Zinc-finger containing family zf-CCCH_2 PF14608.6 CCF38872.1 - 0.034 14.6 20.7 0.077 13.5 5.4 2.7 3 0 0 3 3 3 0 RNA-binding, Nab2-type zinc finger PP-binding PF00550.25 CCF38873.1 - 2.1e-12 47.2 0.0 2.9e-12 46.8 0.0 1.2 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.6 CCF38873.1 - 3.2e-05 24.1 0.1 4e-05 23.8 0.1 1.2 1 0 0 1 1 1 1 Acyl-carrier DEAD PF00270.29 CCF38874.1 - 5.7e-46 156.5 1.3 9.2e-46 155.8 1.3 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF38874.1 - 6e-32 110.3 0.4 8.7e-31 106.5 0.0 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCF38874.1 - 2.6e-06 27.5 0.0 4.3e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 CCF38874.1 - 0.00018 21.3 0.1 0.00037 20.3 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CCF38874.1 - 0.00031 21.1 1.8 0.0012 19.2 0.7 2.2 2 1 0 2 2 2 1 AAA domain CMS1 PF14617.6 CCF38874.1 - 0.024 14.0 0.0 0.051 12.9 0.0 1.5 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit AAA_22 PF13401.6 CCF38874.1 - 0.031 14.5 0.9 0.19 12.0 0.9 2.2 1 1 0 1 1 1 0 AAA domain Helicase_RecD PF05127.14 CCF38874.1 - 0.058 13.3 0.0 0.12 12.3 0.0 1.6 1 0 0 1 1 1 0 Helicase UvrD-helicase PF00580.21 CCF38874.1 - 0.07 12.6 0.4 0.1 12.1 0.3 1.4 1 1 0 1 1 1 0 UvrD/REP helicase N-terminal domain Flavi_DEAD PF07652.14 CCF38874.1 - 0.079 12.9 0.2 0.38 10.7 0.2 2.2 1 1 0 1 1 1 0 Flavivirus DEAD domain IL17R_D_N PF16742.5 CCF38874.1 - 0.084 12.9 0.0 0.23 11.5 0.0 1.7 1 0 0 1 1 1 0 N-terminus of interleukin 17 receptor D fragilysinNterm PF16376.5 CCF38874.1 - 0.092 12.5 0.0 0.27 11.0 0.0 1.7 1 0 0 1 1 1 0 N-terminal domain of fragilysin tRNA-synt_1b PF00579.25 CCF38874.1 - 0.093 12.0 0.2 0.47 9.7 0.0 2.1 3 0 0 3 3 3 0 tRNA synthetases class I (W and Y) dCMP_cyt_deam_1 PF00383.23 CCF38875.1 - 6.3e-14 51.7 0.2 8.3e-14 51.3 0.2 1.1 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region dCMP_cyt_deam_2 PF08211.12 CCF38875.1 - 1.1e-08 35.4 2.1 1e-07 32.2 0.1 2.1 2 0 0 2 2 2 1 Cytidine and deoxycytidylate deaminase zinc-binding region LmjF365940-deam PF14421.6 CCF38875.1 - 0.0034 17.0 1.7 0.4 10.3 0.0 2.1 1 1 1 2 2 2 2 A distinct subfamily of CDD/CDA-like deaminases XOO_2897-deam PF14440.6 CCF38875.1 - 0.098 12.8 0.0 0.2 11.8 0.0 1.5 2 0 0 2 2 2 0 Xanthomonas XOO_2897-like deaminase adh_short_C2 PF13561.6 CCF38876.1 - 3.8e-31 108.5 0.0 3.5e-30 105.3 0.0 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF38876.1 - 5.5e-23 81.4 0.0 8e-23 80.9 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF38876.1 - 0.079 12.9 0.0 0.42 10.5 0.0 2.1 2 1 0 2 2 2 0 KR domain DnaJ_C PF01556.18 CCF38877.1 - 5.1e-38 130.5 0.1 7e-38 130.0 0.1 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 CCF38877.1 - 2.8e-26 91.4 3.1 4.9e-26 90.6 3.1 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 CCF38877.1 - 1.3e-15 57.5 20.0 2.3e-15 56.7 20.0 1.4 1 0 0 1 1 1 1 DnaJ central domain HypA PF01155.19 CCF38877.1 - 0.16 12.0 9.9 0.64 10.1 2.7 2.4 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc-ribbons_6 PF07191.12 CCF38877.1 - 0.17 11.9 6.3 2.5 8.2 1.8 2.4 2 0 0 2 2 2 0 zinc-ribbons zinc_ribbon_9 PF14369.6 CCF38877.1 - 0.43 10.9 3.2 32 4.9 0.1 3.2 3 0 0 3 3 3 0 zinc-ribbon Anti-TRAP PF15777.5 CCF38877.1 - 1.5 8.9 18.2 0.82 9.7 3.1 2.8 1 1 1 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein DUF2614 PF11023.8 CCF38877.1 - 3.6 7.7 6.7 9 6.4 1.2 2.2 1 1 1 2 2 2 0 Zinc-ribbon containing domain Fungal_trans_2 PF11951.8 CCF38878.1 - 3.3e-06 26.2 0.0 4.5e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF38878.1 - 0.00094 19.3 10.4 0.0016 18.5 10.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain COesterase PF00135.28 CCF38879.1 - 9.2e-79 265.6 0.0 1.8e-78 264.7 0.0 1.4 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CCF38879.1 - 7.6e-06 25.9 0.1 6.6e-05 22.9 0.1 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold peroxidase PF00141.23 CCF38880.1 - 1.7e-13 50.8 0.0 4.8e-13 49.3 0.1 1.7 2 0 0 2 2 2 1 Peroxidase PSI_PSAK PF01241.18 CCF38880.1 - 0.15 12.1 0.0 0.32 11.1 0.0 1.5 1 0 0 1 1 1 0 Photosystem I psaG / psaK MARVEL PF01284.23 CCF38882.1 - 6.7e-23 81.3 16.2 7.8e-23 81.1 16.2 1.0 1 0 0 1 1 1 1 Membrane-associating domain p450 PF00067.22 CCF38883.1 - 1.6e-59 201.9 0.0 3.5e-59 200.8 0.0 1.4 1 1 0 1 1 1 1 Cytochrome P450 Methyltransf_23 PF13489.6 CCF38884.1 - 1.7e-06 28.0 0.0 2.9e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF38884.1 - 8.6e-05 23.2 0.0 0.00018 22.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.9 CCF38884.1 - 0.0011 18.7 0.0 0.0016 18.2 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_2 PF00891.18 CCF38884.1 - 0.0016 17.8 0.0 0.0022 17.4 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase domain PrmA PF06325.13 CCF38884.1 - 0.0036 16.7 0.0 0.0053 16.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 CCF38884.1 - 0.012 15.2 0.0 0.017 14.7 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_31 PF13847.6 CCF38884.1 - 0.018 14.9 0.0 0.026 14.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 CCF38884.1 - 0.032 15.0 0.0 0.073 13.8 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.12 CCF38884.1 - 0.18 12.5 0.0 0.39 11.4 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain AMP-binding PF00501.28 CCF38885.1 - 1.5e-33 116.0 0.0 2.4e-33 115.4 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme Phage_tail_X PF05489.12 CCF38885.1 - 0.13 12.0 0.1 4.4 7.0 0.0 2.7 2 0 0 2 2 2 0 Phage Tail Protein X Epimerase PF01370.21 CCF38887.1 - 0.022 14.2 0.0 0.035 13.6 0.0 1.4 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family Cu_bind_like PF02298.17 CCF38888.1 - 0.00064 19.7 0.0 0.00097 19.1 0.0 1.3 1 0 0 1 1 1 1 Plastocyanin-like domain NYD-SP28_assoc PF14775.6 CCF38889.1 - 0.046 13.8 2.0 0.074 13.2 2.0 1.3 1 0 0 1 1 1 0 Sperm tail C-terminal domain Fmp27_WPPW PF10359.9 CCF38889.1 - 0.1 11.4 0.1 0.12 11.2 0.1 1.0 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain 2-Hacid_dh_C PF02826.19 CCF38891.1 - 3.4e-57 192.7 0.0 6.1e-57 191.8 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CCF38891.1 - 2.5e-22 79.0 0.0 2.8e-22 78.8 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 CCF38891.1 - 3.4e-05 24.1 0.1 6.8e-05 23.1 0.0 1.5 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.12 CCF38891.1 - 0.085 12.4 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain Ank_2 PF12796.7 CCF38892.1 - 4.9e-22 78.3 0.0 2.7e-07 31.1 0.0 4.3 2 1 0 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CCF38892.1 - 7.2e-20 70.8 1.4 0.00012 22.3 0.1 6.0 3 3 3 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCF38892.1 - 5.6e-15 54.0 1.0 0.19 12.4 0.1 7.2 7 0 0 7 7 7 4 Ankyrin repeat Ank_4 PF13637.6 CCF38892.1 - 1.2e-13 51.3 1.0 0.071 13.7 0.0 5.5 3 1 3 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.30 CCF38892.1 - 8.6e-12 44.9 3.6 0.0046 17.3 0.1 6.7 6 0 0 6 6 6 4 Ankyrin repeat Zn_clus PF00172.18 CCF38892.1 - 4 7.6 7.4 8.3 6.6 7.4 1.5 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain FMO-like PF00743.19 CCF38895.1 - 4.4e-24 84.8 0.0 3.7e-11 42.2 0.1 3.1 2 1 1 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 CCF38895.1 - 3.4e-15 56.1 0.1 1.3e-10 41.1 0.3 3.7 3 1 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CCF38895.1 - 5.4e-11 42.3 0.0 2.2e-10 40.2 0.0 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CCF38895.1 - 2.4e-09 36.8 0.2 1.3e-06 27.8 0.1 2.5 2 1 1 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 CCF38895.1 - 5e-07 29.8 0.0 0.00021 21.3 0.0 2.8 3 0 0 3 3 3 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 CCF38895.1 - 1.7e-06 28.2 0.0 5.6e-06 26.5 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CCF38895.1 - 0.00022 21.0 0.3 0.45 10.0 0.0 2.5 3 0 0 3 3 3 2 FAD dependent oxidoreductase Pyr_redox PF00070.27 CCF38895.1 - 0.0068 16.9 0.2 0.35 11.5 0.0 2.7 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CCF38895.1 - 0.0078 15.5 0.1 0.026 13.8 0.0 1.7 2 0 0 2 2 2 1 Thi4 family Glu_dehyd_C PF16912.5 CCF38895.1 - 0.046 13.2 0.0 0.095 12.2 0.0 1.5 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus HI0933_like PF03486.14 CCF38895.1 - 0.11 11.2 0.0 0.2 10.3 0.0 1.4 1 0 0 1 1 1 0 HI0933-like protein MFS_1 PF07690.16 CCF38896.1 - 5e-11 42.1 21.1 8.3e-11 41.4 21.1 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.16 CCF38896.1 - 9e-06 25.5 1.7 9e-06 25.5 1.7 1.8 2 0 0 2 2 2 1 Ion channel regulatory protein UNC-93 Sugar_tr PF00083.24 CCF38896.1 - 0.088 11.6 13.2 0.31 9.9 13.2 1.9 1 1 0 1 1 1 0 Sugar (and other) transporter ADH_N PF08240.12 CCF38897.1 - 3.8e-29 100.8 3.0 6.5e-29 100.0 3.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCF38897.1 - 1e-24 87.0 0.2 1e-24 87.0 0.2 2.1 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCF38897.1 - 1.9e-08 35.4 0.3 1e-07 33.1 0.1 2.1 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 CCF38897.1 - 2.8e-08 33.5 1.9 2.2e-07 30.6 1.9 2.0 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 CCF38897.1 - 7.9e-07 28.6 1.8 7.9e-07 28.6 1.8 1.8 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain PPR PF01535.20 CCF38897.1 - 0.15 12.3 0.1 1.3 9.4 0.0 2.3 2 0 0 2 2 2 0 PPR repeat Ribonuc_L-PSP PF01042.21 CCF38898.1 - 4.6e-21 75.1 0.0 5.2e-21 74.9 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP Aldedh PF00171.22 CCF38899.1 - 7.5e-159 529.1 2.9 1.4e-113 379.9 0.5 2.0 1 1 1 2 2 2 2 Aldehyde dehydrogenase family MOSC_N PF03476.16 CCF38900.1 - 5.5e-10 39.2 0.0 8.3e-09 35.4 0.0 2.3 1 1 0 1 1 1 1 MOSC N-terminal beta barrel domain Cyt-b5 PF00173.28 CCF38901.1 - 4.7e-23 81.1 0.1 6.1e-23 80.8 0.1 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain U62_UL91 PF17442.2 CCF38901.1 - 0.096 12.7 0.1 0.18 11.8 0.1 1.4 1 0 0 1 1 1 0 Functional domain of U62 and UL91 proteins TFA2_Winged_2 PF18121.1 CCF38902.1 - 1.6e-19 69.3 1.2 3.1e-19 68.4 0.5 1.8 2 0 0 2 2 2 1 TFA2 Winged helix domain 2 TFIIE_beta PF02186.15 CCF38902.1 - 1.1e-11 44.9 0.0 3e-11 43.4 0.0 1.8 1 0 0 1 1 1 1 TFIIE beta subunit core domain Malate_DH PF12434.8 CCF38902.1 - 0.34 11.0 1.8 3.7 7.7 0.1 2.9 2 0 0 2 2 2 0 Malate dehydrogenase enzyme DUF3123 PF11321.8 CCF38902.1 - 0.62 10.8 4.9 1.1 9.9 1.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3123) DSBA PF01323.20 CCF38903.1 - 3e-34 118.5 0.0 3.5e-34 118.3 0.0 1.0 1 0 0 1 1 1 1 DSBA-like thioredoxin domain Thioredoxin_4 PF13462.6 CCF38903.1 - 2.1e-06 28.0 0.0 9.5e-05 22.6 0.0 2.1 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_5 PF13743.6 CCF38903.1 - 0.1 12.3 0.0 0.26 11.0 0.0 1.8 1 1 0 1 1 1 0 Thioredoxin Glyco_hydro_61 PF03443.14 CCF38904.1 - 1.1e-62 211.7 1.4 1.1e-62 211.6 0.1 1.7 2 0 0 2 2 2 1 Glycosyl hydrolase family 61 CBM_1 PF00734.18 CCF38904.1 - 1.1e-22 79.7 17.3 2.1e-11 43.6 3.4 2.7 2 0 0 2 2 2 2 Fungal cellulose binding domain DDE_1 PF03184.19 CCF38905.1 - 2.6e-32 111.9 0.0 6.7e-32 110.5 0.0 1.8 1 1 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 CCF38905.1 - 2.7e-09 36.9 0.0 7.4e-09 35.5 0.0 1.8 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 CCF38905.1 - 3.6e-05 23.4 0.0 7.6e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_23 PF13384.6 CCF38905.1 - 0.065 13.0 0.4 0.71 9.8 0.0 2.6 2 0 0 2 2 2 0 Homeodomain-like domain Inhibitor_I9 PF05922.16 CCF38907.1 - 0.002 18.7 0.4 0.003 18.2 0.4 1.3 1 0 0 1 1 1 1 Peptidase inhibitor I9 Cyc-maltodext_C PF10438.9 CCF38907.1 - 0.14 12.3 0.8 0.39 10.8 0.1 1.9 1 1 1 2 2 2 0 Cyclo-malto-dextrinase C-terminal domain Pkinase PF00069.25 CCF38908.1 - 2.3e-17 63.2 0.4 7.9e-17 61.5 0.4 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF38908.1 - 2.2e-09 37.0 0.2 1.5e-08 34.3 0.2 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase DUF1604 PF07713.13 CCF38909.1 - 1.2e-40 137.1 0.7 8.7e-39 131.2 0.8 2.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1604) G-patch PF01585.23 CCF38909.1 - 5.5e-06 26.2 1.7 1.8e-05 24.5 0.6 2.3 2 0 0 2 2 2 1 G-patch domain G-patch_2 PF12656.7 CCF38909.1 - 0.0062 16.6 4.1 0.0067 16.5 1.1 2.7 2 1 0 2 2 2 1 G-patch domain Cu-oxidase_3 PF07732.15 CCF38911.1 - 2.5e-41 140.4 1.8 1.7e-39 134.5 1.4 2.2 2 0 0 2 2 2 2 Multicopper oxidase Cu-oxidase PF00394.22 CCF38911.1 - 4.9e-25 88.5 0.1 1.1e-24 87.4 0.1 1.5 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 CCF38911.1 - 8.8e-06 25.5 4.9 0.083 12.6 2.0 3.7 3 1 0 3 3 3 3 Multicopper oxidase zf-RING_2 PF13639.6 CCF38913.1 - 0.028 14.8 4.2 0.082 13.3 4.3 1.8 1 1 0 1 1 1 0 Ring finger domain DUF4428 PF14471.6 CCF38913.1 - 0.29 11.1 1.6 1.9 8.5 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4428) Tim54 PF11711.8 CCF38914.1 - 3e-37 128.3 0.1 4.3e-37 127.8 0.1 1.2 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 TFIIA PF03153.13 CCF38915.1 - 0.11 12.5 20.6 0.12 12.3 20.6 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.9 CCF38915.1 - 1.6 6.9 16.0 1.7 6.8 16.0 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Spt20 PF12090.8 CCF38915.1 - 2.5 7.7 24.7 3.9 7.0 24.7 1.4 1 0 0 1 1 1 0 Spt20 family Presenilin PF01080.17 CCF38915.1 - 3.3 6.4 3.8 3.7 6.2 3.8 1.1 1 0 0 1 1 1 0 Presenilin Suf PF05843.14 CCF38915.1 - 5.5 6.9 9.6 6.9 6.6 9.6 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF3328 PF11807.8 CCF38917.1 - 0.00043 20.1 2.2 0.0016 18.3 2.2 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF3328) DUF3180 PF11377.8 CCF38917.1 - 0.066 13.4 0.1 0.1 12.7 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3180) SKG6 PF08693.10 CCF38918.1 - 0.041 13.3 0.2 0.082 12.3 0.2 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain EVC2_like PF12297.8 CCF38918.1 - 0.063 12.0 0.0 0.089 11.5 0.0 1.1 1 0 0 1 1 1 0 Ellis van Creveld protein 2 like protein Granulin PF00396.18 CCF38918.1 - 5.4 7.4 26.8 0.41 11.0 4.6 3.4 2 1 1 3 3 3 0 Granulin Peptidase_M3 PF01432.20 CCF38919.1 - 8.4e-122 407.7 0.0 1.1e-121 407.3 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M3 YcgL PF05166.13 CCF38919.1 - 0.08 13.3 0.0 14 6.1 0.0 2.9 2 0 0 2 2 2 0 YcgL domain Peptidase_M50B PF13398.6 CCF38919.1 - 0.083 12.5 0.1 0.14 11.7 0.1 1.3 1 0 0 1 1 1 0 Peptidase M50B-like AATF-Che1 PF13339.6 CCF38919.1 - 0.13 12.9 0.7 0.44 11.2 0.2 2.1 2 0 0 2 2 2 0 Apoptosis antagonizing transcription factor ApoO PF09769.9 CCF38920.1 - 4.2e-44 149.7 0.3 1.3e-42 144.8 0.1 2.2 2 0 0 2 2 2 2 Apolipoprotein O Dus PF01207.17 CCF38921.1 - 1.4e-43 149.1 0.2 1e-42 146.4 0.2 2.0 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) PucR PF07905.11 CCF38921.1 - 0.13 12.5 0.1 0.54 10.6 0.0 2.1 1 1 1 2 2 2 0 Purine catabolism regulatory protein-like family Pyrophosphatase PF00719.19 CCF38922.1 - 2.9e-58 196.2 0.1 3.8e-58 195.8 0.1 1.1 1 0 0 1 1 1 1 Inorganic pyrophosphatase SEN1_N PF12726.7 CCF38923.1 - 1.1e-29 103.2 0.1 1.3e-29 103.0 0.1 1.1 1 0 0 1 1 1 1 SEN1 N terminal DUF89 PF01937.19 CCF38924.1 - 0.16 10.9 0.0 0.16 10.9 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function DUF89 HhH-GPD PF00730.25 CCF38925.1 - 7.2e-09 36.1 0.0 1.8e-08 34.8 0.0 1.7 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein DnaJ PF00226.31 CCF38926.1 - 0.0038 17.3 0.0 0.0056 16.8 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain Mito_carr PF00153.27 CCF38927.1 - 7.9e-68 224.5 5.5 9.1e-23 80.0 0.1 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 CCF38927.1 - 0.0077 15.4 5.8 0.67 9.0 0.5 3.3 1 1 3 4 4 4 2 Gammaproteobacterial serine protease Bac_export_2 PF01312.19 CCF38927.1 - 0.041 13.1 0.0 0.063 12.5 0.0 1.2 1 0 0 1 1 1 0 FlhB HrpN YscU SpaS Family HypA PF01155.19 CCF38928.1 - 0.0032 17.5 3.1 0.0038 17.2 3.1 1.1 1 0 0 1 1 1 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DZR PF12773.7 CCF38928.1 - 0.15 12.1 9.4 1 9.5 9.4 2.0 1 1 0 1 1 1 0 Double zinc ribbon DUF3725 PF12523.8 CCF38928.1 - 0.29 11.5 0.2 0.29 11.5 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3725) DUF4379 PF14311.6 CCF38928.1 - 3.1 8.2 12.0 27 5.2 12.2 2.4 1 1 1 2 2 2 0 Probable Zinc-ribbon domain RecR PF02132.15 CCF38928.1 - 6.8 6.4 10.2 0.86 9.2 3.4 2.6 1 1 1 2 2 2 0 RecR protein Homeobox_KN PF05920.11 CCF38929.1 - 2e-14 53.2 3.1 4.5e-14 52.1 3.1 1.7 1 0 0 1 1 1 1 Homeobox KN domain zf-C2H2 PF00096.26 CCF38929.1 - 2.1e-06 27.9 20.3 0.0038 17.6 4.3 4.6 4 0 0 4 4 4 3 Zinc finger, C2H2 type Homeodomain PF00046.29 CCF38929.1 - 8.8e-06 25.5 1.4 2.2e-05 24.2 1.4 1.6 1 0 0 1 1 1 1 Homeodomain zf-C2H2_4 PF13894.6 CCF38929.1 - 0.0015 19.2 4.1 0.0015 19.2 4.1 4.6 4 1 0 4 4 4 2 C2H2-type zinc finger zf-C2H2_2 PF12756.7 CCF38929.1 - 0.48 10.8 6.7 11 6.4 0.2 3.3 2 1 0 3 3 3 0 C2H2 type zinc-finger (2 copies) A2L_zn_ribbon PF08792.10 CCF38929.1 - 1.2 8.9 4.9 4.2 7.2 0.0 2.8 3 0 0 3 3 3 0 A2L zinc ribbon domain MFS_1 PF07690.16 CCF38930.1 - 8.5e-41 140.0 41.4 8.5e-41 140.0 41.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily R3H PF01424.22 CCF38931.1 - 3e-15 56.0 0.0 6.2e-15 54.9 0.0 1.5 1 0 0 1 1 1 1 R3H domain G-patch PF01585.23 CCF38931.1 - 7.1e-11 41.8 1.0 1.9e-10 40.5 1.0 1.8 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 CCF38931.1 - 0.0093 16.0 0.8 0.0093 16.0 0.8 2.4 3 0 0 3 3 3 1 G-patch domain Histone PF00125.24 CCF38932.1 - 9.1e-22 77.8 2.0 1.1e-21 77.5 2.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CCF38932.1 - 2e-05 24.8 0.0 4.7e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 CCF38932.1 - 0.00033 21.1 0.0 0.00056 20.4 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A RP-C PF03428.13 CCF38932.1 - 0.045 13.4 0.1 0.11 12.1 0.1 1.6 1 1 0 1 1 1 0 Replication protein C N-terminal domain Totivirus_coat PF05518.11 CCF38933.1 - 4.9 5.1 12.3 5.3 5.0 12.3 1.0 1 0 0 1 1 1 0 Totivirus coat protein Cation_efflux PF01545.21 CCF38935.1 - 1.9e-51 174.6 8.9 9.8e-51 172.3 8.9 1.9 1 1 0 1 1 1 1 Cation efflux family HABP4_PAI-RBP1 PF04774.15 CCF38936.1 - 6.4 7.6 9.9 0.22 12.3 2.4 2.2 2 0 0 2 2 2 0 Hyaluronan / mRNA binding family SAPS PF04499.15 CCF38937.1 - 1.4e-193 644.2 0.0 5.3e-193 642.2 0.0 2.0 2 0 0 2 2 2 1 SIT4 phosphatase-associated protein p450 PF00067.22 CCF38938.1 - 1.6e-67 228.3 0.0 1.7e-67 228.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 PPR_2 PF13041.6 CCF38939.1 - 0.00027 21.1 0.0 10 6.4 0.0 4.6 4 0 0 4 4 4 1 PPR repeat family PPR PF01535.20 CCF38939.1 - 0.003 17.7 0.0 11 6.6 0.0 3.9 3 0 0 3 3 3 2 PPR repeat PPR_3 PF13812.6 CCF38939.1 - 0.12 12.4 0.0 33 4.6 0.0 3.7 4 0 0 4 4 4 0 Pentatricopeptide repeat domain DUF3850 PF12961.7 CCF38939.1 - 0.17 12.0 0.0 0.41 10.7 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3850) Ribosomal_S18 PF01084.20 CCF38940.1 - 5.5e-11 42.5 0.0 1e-10 41.6 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S18 S4 PF01479.25 CCF38941.1 - 3.1e-11 42.8 0.0 7.8e-11 41.5 0.0 1.7 1 0 0 1 1 1 1 S4 domain Ribosomal_S4 PF00163.19 CCF38941.1 - 3e-09 37.7 1.6 6.1e-09 36.7 1.6 1.5 1 1 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain THDPS_N_2 PF14805.6 CCF38941.1 - 0.048 13.9 0.0 0.084 13.1 0.0 1.5 1 0 0 1 1 1 0 Tetrahydrodipicolinate N-succinyltransferase N-terminal Glyco_hydro_61 PF03443.14 CCF38942.1 - 3.6e-64 216.5 0.0 4.4e-64 216.2 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 NPCBM_assoc PF10633.9 CCF38942.1 - 0.091 13.0 0.1 0.62 10.3 0.0 2.1 2 0 0 2 2 2 0 NPCBM-associated, NEW3 domain of alpha-galactosidase DUF2462 PF09495.10 CCF38943.1 - 5.5e-17 62.3 9.5 5.5e-17 62.3 9.5 1.6 1 1 1 2 2 2 1 Protein of unknown function (DUF2462) DUF4588 PF15251.6 CCF38945.1 - 5.7e-09 36.1 0.3 8.6e-09 35.5 0.3 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4588) PHtD_u1 PF16645.5 CCF38945.1 - 5.5 7.5 11.8 0.65 10.5 4.7 2.7 1 1 1 2 2 2 0 Unstructured region on Pneumococcal histidine triad protein SNF2_N PF00176.23 CCF38946.1 - 7.9e-76 255.0 0.1 1.5e-75 254.1 0.1 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.10 CCF38946.1 - 4.7e-42 142.6 1.0 4.7e-42 142.6 1.0 3.0 3 0 0 3 3 3 1 SLIDE HAND PF09110.11 CCF38946.1 - 1.4e-35 122.4 6.5 1.4e-35 122.4 6.5 4.1 4 0 0 4 4 4 1 HAND Helicase_C PF00271.31 CCF38946.1 - 1.6e-17 63.8 0.3 6.3e-17 61.9 0.0 2.2 2 0 0 2 2 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCF38946.1 - 3e-11 43.6 0.1 2.3e-10 40.7 0.0 2.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 CCF38946.1 - 0.00012 21.9 0.0 0.00041 20.2 0.0 1.9 1 0 0 1 1 1 1 DEAD/DEAH box helicase Myb_DNA-binding PF00249.31 CCF38946.1 - 0.00018 21.6 0.9 0.18 12.1 0.0 3.3 3 0 0 3 3 3 2 Myb-like DNA-binding domain SWI2_SNF2 PF18766.1 CCF38946.1 - 0.00027 20.7 0.0 0.00087 19.0 0.0 1.8 1 0 0 1 1 1 1 SWI2/SNF2 ATPase DUF1086 PF06461.11 CCF38946.1 - 0.0003 20.7 0.1 0.00069 19.5 0.1 1.5 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1086) HDA2-3 PF11496.8 CCF38946.1 - 0.00032 20.0 0.0 0.0012 18.1 0.0 2.0 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 Occludin_ELL PF07303.13 CCF38946.1 - 0.032 14.9 3.5 0.11 13.3 3.5 1.9 1 0 0 1 1 1 0 Occludin homology domain WavE PF07507.11 CCF38947.1 - 0.042 13.0 0.0 0.044 13.0 0.0 1.0 1 0 0 1 1 1 0 WavE lipopolysaccharide synthesis WD40 PF00400.32 CCF38948.1 - 8.6e-29 99.2 31.5 0.00016 22.4 0.2 10.6 10 1 1 11 11 11 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF38948.1 - 1.7e-15 57.1 5.6 0.00028 21.1 0.1 6.2 4 2 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain CPSF_A PF03178.15 CCF38948.1 - 0.0006 19.2 0.0 0.0031 16.9 0.0 2.0 2 0 0 2 2 2 1 CPSF A subunit region PD40 PF07676.12 CCF38948.1 - 0.002 18.0 0.3 5.9 7.0 0.0 4.4 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 CCF38948.1 - 0.015 14.3 4.9 0.92 8.4 0.2 3.9 3 1 1 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Glyco_tran_28_C PF04101.16 CCF38949.1 - 8.6e-18 64.9 0.0 2.1e-17 63.6 0.0 1.6 1 1 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain UDPGT PF00201.18 CCF38949.1 - 0.14 11.0 0.1 0.19 10.5 0.1 1.1 1 0 0 1 1 1 0 UDP-glucoronosyl and UDP-glucosyl transferase FtsX PF02687.21 CCF38950.1 - 8.5 6.9 7.6 1.7 9.2 4.1 1.7 2 0 0 2 2 2 0 FtsX-like permease family Ank_2 PF12796.7 CCF38951.1 - 9.3e-57 189.6 7.0 4.6e-13 49.5 0.0 7.0 4 2 2 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CCF38951.1 - 3.9e-42 142.1 0.3 4.1e-06 27.2 0.0 8.8 6 2 3 9 9 8 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCF38951.1 - 1.7e-33 110.9 3.0 0.0067 16.9 0.0 11.7 12 0 0 12 12 11 7 Ankyrin repeat Ank PF00023.30 CCF38951.1 - 8.5e-30 101.9 11.6 0.0032 17.8 0.0 11.3 12 0 0 12 12 11 7 Ankyrin repeat Ank_5 PF13857.6 CCF38951.1 - 1.6e-26 92.0 12.1 0.00017 21.8 0.3 10.0 5 2 5 10 10 10 8 Ankyrin repeats (many copies) Abhydrolase_6 PF12697.7 CCF38951.1 - 6.1e-05 23.7 0.0 6.1e-05 23.7 0.0 2.5 2 1 0 2 2 1 1 Alpha/beta hydrolase family AAA_16 PF13191.6 CCF38951.1 - 8.6e-05 23.0 0.1 0.00052 20.4 0.1 2.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 CCF38951.1 - 0.00015 22.0 0.6 0.00063 20.0 0.0 2.4 3 0 0 3 3 3 1 AAA domain DUF676 PF05057.14 CCF38951.1 - 0.00067 19.2 0.0 0.0014 18.2 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Hydrolase_4 PF12146.8 CCF38951.1 - 0.0014 17.9 0.0 0.0034 16.7 0.0 1.6 1 0 0 1 1 1 1 Serine aminopeptidase, S33 PGAP1 PF07819.13 CCF38951.1 - 0.0079 15.9 0.0 0.019 14.7 0.0 1.6 1 0 0 1 1 1 1 PGAP1-like protein Cutinase PF01083.22 CCF38951.1 - 0.01 15.8 0.0 0.028 14.4 0.0 1.6 1 0 0 1 1 1 0 Cutinase Thioesterase PF00975.20 CCF38951.1 - 0.054 13.6 0.1 0.88 9.6 0.0 2.7 2 0 0 2 2 2 0 Thioesterase domain Lipase_3 PF01764.25 CCF38951.1 - 0.092 12.6 0.0 0.25 11.2 0.0 1.7 1 0 0 1 1 1 0 Lipase (class 3) SUIM_assoc PF16619.5 CCF38951.1 - 1.9 8.6 16.5 4.9 7.3 5.3 2.9 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 MRP-S28 PF10213.9 CCF38952.1 - 6.6e-49 165.5 1.2 1.4e-48 164.5 1.2 1.5 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit protein CALM_bind PF16025.5 CCF38952.1 - 0.025 15.0 0.2 0.076 13.5 0.2 1.8 1 0 0 1 1 1 0 Calcium-dependent calmodulin binding TFR_dimer PF04253.15 CCF38954.1 - 7.1e-29 100.4 0.0 1.1e-28 99.7 0.0 1.3 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 CCF38954.1 - 3.4e-16 59.5 0.0 7e-16 58.5 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 CCF38954.1 - 4.9e-13 48.9 0.2 1e-12 47.9 0.2 1.5 1 0 0 1 1 1 1 PA domain Nicastrin PF05450.15 CCF38954.1 - 0.074 12.5 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 Nicastrin DUF3439 PF11921.8 CCF38954.1 - 1.2 9.1 4.3 2.3 8.2 4.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) DUF4246 PF14033.6 CCF38956.1 - 1.2e-183 611.4 0.2 1.4e-183 611.1 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF4246) HTH_33 PF13592.6 CCF38956.1 - 0.021 14.4 0.0 0.056 13.1 0.0 1.7 1 0 0 1 1 1 0 Winged helix-turn helix RTA1 PF04479.13 CCF38957.1 - 6.1e-59 199.1 4.2 9.7e-59 198.4 4.2 1.2 1 0 0 1 1 1 1 RTA1 like protein DUF3169 PF11368.8 CCF38957.1 - 0.18 11.3 4.6 0.29 10.6 0.0 3.1 2 2 2 4 4 4 0 Protein of unknown function (DUF3169) Epimerase PF01370.21 CCF38958.1 - 8.1e-22 77.8 0.0 1.3e-21 77.2 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CCF38958.1 - 5e-14 52.4 0.0 7.2e-14 51.9 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 CCF38958.1 - 2.3e-13 49.8 0.0 3.1e-13 49.4 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 CCF38958.1 - 7.6e-09 35.1 0.0 8.6e-09 34.9 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 CCF38958.1 - 3e-08 33.2 0.0 1.4e-05 24.4 0.0 2.2 2 0 0 2 2 2 2 Male sterility protein NAD_binding_10 PF13460.6 CCF38958.1 - 5.2e-07 29.7 0.0 1.3e-06 28.5 0.0 1.4 1 1 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 CCF38958.1 - 1.2e-06 27.9 0.0 5.7e-06 25.7 0.1 1.9 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein KR PF08659.10 CCF38958.1 - 0.00026 21.0 0.2 0.16 11.9 0.0 2.2 2 0 0 2 2 2 2 KR domain FTA4 PF13093.6 CCF38959.1 - 1.3e-26 93.7 0.0 1.4e-26 93.6 0.0 1.0 1 0 0 1 1 1 1 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 DUF2306 PF10067.9 CCF38960.1 - 2.9e-12 47.0 8.6 2.9e-12 47.0 8.6 2.0 2 0 0 2 2 2 1 Predicted membrane protein (DUF2306) Fn3-like PF14310.6 CCF38961.1 - 1.2e-25 89.4 0.6 1.8e-25 88.9 0.6 1.2 1 0 0 1 1 1 1 Fibronectin type III-like domain BiPBP_C PF06832.12 CCF38961.1 - 0.049 13.7 0.0 0.12 12.4 0.0 1.7 2 0 0 2 2 2 0 Penicillin-Binding Protein C-terminus Family CARDB PF07705.11 CCF38961.1 - 0.069 13.4 0.5 0.11 12.8 0.5 1.4 1 1 0 1 1 1 0 CARDB CLN3 PF02487.17 CCF38962.1 - 1e-52 179.5 3.8 1.3e-52 179.2 3.8 1.0 1 0 0 1 1 1 1 CLN3 protein Keratin_assoc PF09775.9 CCF38962.1 - 0.15 11.7 1.0 0.22 11.2 1.0 1.3 1 0 0 1 1 1 0 Keratinocyte-associated protein 2 Acetyltransf_8 PF13523.6 CCF38963.1 - 8.3e-36 122.8 0.1 1.3e-35 122.2 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain MCU PF04678.13 CCF38964.1 - 0.00013 22.1 0.8 0.00042 20.5 0.0 1.9 2 0 0 2 2 2 1 Mitochondrial calcium uniporter DUF1281 PF06924.11 CCF38964.1 - 0.1 12.1 0.2 0.12 11.9 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1281) Pex14_N PF04695.13 CCF38964.1 - 0.31 11.7 3.4 0.41 11.3 3.4 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region RRN3 PF05327.11 CCF38964.1 - 8.2 4.8 8.6 9 4.7 8.6 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 THOC7 PF05615.13 CCF38967.1 - 6.2e-42 143.0 8.4 6.2e-42 143.0 8.4 2.1 1 1 1 2 2 2 1 Tho complex subunit 7 Herpes_UL17 PF04559.12 CCF38967.1 - 0.072 11.9 0.8 0.092 11.5 0.8 1.2 1 0 0 1 1 1 0 Herpesvirus UL17 protein DUF4407 PF14362.6 CCF38967.1 - 2.7 7.3 13.6 4.3 6.6 13.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) NUDE_C PF04880.13 CCF38967.1 - 3.8 8.0 12.9 1.1 9.7 0.3 2.7 3 0 0 3 3 3 0 NUDE protein, C-terminal conserved region FUSC PF04632.12 CCF38967.1 - 4.5 5.7 5.0 6 5.3 5.0 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family TBCA PF02970.16 CCF38968.1 - 4.8e-22 78.1 4.8 4.8e-22 78.1 4.8 1.4 1 1 0 1 1 1 1 Tubulin binding cofactor A GCP_N_terminal PF17681.1 CCF38968.1 - 0.065 12.9 0.1 0.072 12.7 0.1 1.1 1 0 0 1 1 1 0 Gamma tubulin complex component N-terminal Csm1_N PF18504.1 CCF38968.1 - 0.35 11.2 6.6 0.2 12.0 1.6 2.4 1 1 1 2 2 2 0 Csm1 N-terminal domain Abhydrolase_6 PF12697.7 CCF38969.1 - 6.6e-18 66.1 5.9 7.7e-18 65.9 5.9 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Thioesterase PF00975.20 CCF38969.1 - 0.0012 19.0 0.1 0.0018 18.4 0.1 1.3 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_1 PF00561.20 CCF38969.1 - 0.0023 17.6 0.0 0.17 11.5 0.0 2.3 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CCF38969.1 - 0.0027 17.0 0.7 0.004 16.4 0.7 1.6 1 1 0 1 1 1 1 Serine aminopeptidase, S33 DUF900 PF05990.12 CCF38969.1 - 0.046 13.2 0.0 0.069 12.6 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Lipase_2 PF01674.18 CCF38969.1 - 0.085 12.4 0.0 0.11 12.0 0.0 1.1 1 0 0 1 1 1 0 Lipase (class 2) PGAP1 PF07819.13 CCF38969.1 - 0.22 11.2 0.0 0.34 10.6 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein RRM_1 PF00076.22 CCF38970.1 - 7.8e-12 44.8 0.0 1.1e-11 44.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 CCF38970.1 - 0.00015 21.6 0.0 0.00022 21.1 0.0 1.3 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Topoisom_bac PF01131.20 CCF38971.1 - 3.4e-74 250.3 0.0 4e-74 250.1 0.0 1.1 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.22 CCF38971.1 - 1.5e-19 70.1 0.0 2.8e-19 69.2 0.0 1.5 1 0 0 1 1 1 1 Toprim domain DUF1295 PF06966.12 CCF38972.1 - 1.3e-35 123.0 11.0 1.6e-35 122.7 11.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) ICMT PF04140.14 CCF38972.1 - 0.019 15.4 2.7 0.15 12.5 0.4 2.7 2 1 0 2 2 2 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family Hydrolase_like PF13242.6 CCF38973.1 - 2.6e-16 59.4 0.1 3.2e-16 59.2 0.1 1.1 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 CCF38973.1 - 0.065 13.5 0.0 0.078 13.2 0.0 1.2 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase GDA1_CD39 PF01150.17 CCF38974.1 - 1.8e-106 356.3 0.0 2.6e-106 355.8 0.0 1.1 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family DUF775 PF05603.12 CCF38975.1 - 1.3e-59 201.1 0.0 1.5e-59 200.9 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF775) NUDIX PF00293.28 CCF38976.1 - 9.7e-11 41.8 0.1 1.9e-10 40.9 0.1 1.4 1 0 0 1 1 1 1 NUDIX domain DUF4743 PF15916.5 CCF38976.1 - 5.2e-10 39.3 0.0 9.8e-10 38.5 0.0 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4743) RNA_pol_Rpb8 PF03870.15 CCF38977.1 - 3.8e-47 160.0 0.2 4.3e-47 159.8 0.2 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 RNA_pol_RpbG PF16992.5 CCF38977.1 - 0.00011 22.3 0.1 0.03 14.4 0.0 2.1 2 0 0 2 2 2 2 DNA-directed RNA polymerase, subunit G NB-ARC PF00931.22 CCF38977.1 - 0.091 11.9 0.0 0.12 11.6 0.0 1.1 1 0 0 1 1 1 0 NB-ARC domain PAXNEB PF05625.11 CCF38978.1 - 1.4e-100 337.1 0.0 1.6e-100 336.8 0.0 1.0 1 0 0 1 1 1 1 PAXNEB protein tRNA_int_endo PF01974.17 CCF38979.1 - 6.9e-14 51.7 0.0 1.3e-13 50.8 0.0 1.4 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain HemY_N PF07219.13 CCF38979.1 - 0.34 11.1 1.1 0.58 10.4 1.1 1.3 1 0 0 1 1 1 0 HemY protein N-terminus zf-C3HC4_3 PF13920.6 CCF38980.1 - 4.8e-09 35.9 12.5 7.8e-09 35.3 12.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CCF38980.1 - 0.04 13.8 13.0 0.067 13.1 13.0 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 GGA_N-GAT PF18308.1 CCF38980.1 - 1.4 8.6 4.6 19 5.0 0.2 2.6 2 0 0 2 2 2 0 GGA N-GAT domain Abhydrolase_3 PF07859.13 CCF38981.1 - 1.3e-43 149.3 0.0 1.7e-43 148.9 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 CCF38981.1 - 1.7e-06 27.2 0.1 8.2e-06 25.0 0.1 1.8 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_6 PF12697.7 CCF38981.1 - 0.00053 20.7 2.3 0.00053 20.7 2.3 1.6 2 0 0 2 2 2 1 Alpha/beta hydrolase family AXE1 PF05448.12 CCF38981.1 - 0.015 14.0 0.1 4.4 5.9 0.0 2.1 2 0 0 2 2 2 0 Acetyl xylan esterase (AXE1) Abhydrolase_2 PF02230.16 CCF38981.1 - 0.033 14.0 0.0 0.066 13.0 0.0 1.4 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase DUF829 PF05705.14 CCF38981.1 - 0.044 13.7 0.0 0.15 11.9 0.0 1.9 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF829) Esterase PF00756.20 CCF38981.1 - 0.05 13.2 0.0 4.7 6.8 0.0 2.4 2 0 0 2 2 2 0 Putative esterase Peptidase_S9 PF00326.21 CCF38981.1 - 0.16 11.4 0.0 0.44 10.0 0.0 1.7 1 0 0 1 1 1 0 Prolyl oligopeptidase family His_Phos_2 PF00328.22 CCF38982.1 - 3.3e-07 30.0 0.7 1.3e-06 28.0 0.7 1.8 1 1 1 2 2 2 1 Histidine phosphatase superfamily (branch 2) DUF348 PF03990.14 CCF38982.1 - 0.095 12.5 0.1 8.7 6.2 0.1 2.5 2 0 0 2 2 2 0 G5-linked-Ubiquitin-like domain YajC PF02699.15 CCF38982.1 - 0.1 12.5 0.1 0.56 10.1 0.2 2.0 2 0 0 2 2 2 0 Preprotein translocase subunit DHDPS PF00701.22 CCF38983.1 - 2.3e-48 164.4 0.0 2.8e-48 164.1 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family PEP_mutase PF13714.6 CCF38983.1 - 0.0059 16.1 0.0 0.0099 15.4 0.0 1.3 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase HEAT PF02985.22 CCF38984.1 - 4.5e-16 57.6 3.1 0.0052 16.9 0.1 7.7 7 0 0 7 7 6 4 HEAT repeat HEAT_2 PF13646.6 CCF38984.1 - 1.3e-11 44.7 10.8 0.0027 18.0 0.3 7.4 5 1 3 8 8 8 5 HEAT repeats HEAT_EZ PF13513.6 CCF38984.1 - 3.7e-11 43.3 14.9 1.1e-05 25.8 0.1 8.0 7 1 2 9 9 9 4 HEAT-like repeat RIX1 PF08167.12 CCF38984.1 - 1.6e-07 31.3 1.6 0.092 12.5 0.0 4.2 4 0 0 4 4 4 3 rRNA processing/ribosome biogenesis Cnd1 PF12717.7 CCF38984.1 - 2.7e-07 30.8 0.3 0.0079 16.2 0.0 3.8 3 1 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 CCF38984.1 - 3e-05 22.8 0.2 0.048 12.2 0.1 3.2 2 2 0 2 2 2 2 Adaptin N terminal region CLASP_N PF12348.8 CCF38984.1 - 3.6e-05 23.5 0.0 0.00077 19.1 0.0 3.0 3 0 0 3 3 3 1 CLASP N terminal IBN_N PF03810.19 CCF38984.1 - 7.3e-05 22.6 1.3 0.00044 20.1 0.7 2.7 2 0 0 2 2 2 1 Importin-beta N-terminal domain Vac14_Fab1_bd PF12755.7 CCF38984.1 - 0.00019 22.0 0.0 0.36 11.5 0.0 4.0 2 1 2 4 4 4 1 Vacuolar 14 Fab1-binding region Arm PF00514.23 CCF38984.1 - 0.00088 19.2 2.1 18 5.6 0.0 5.5 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat Tti2 PF10521.9 CCF38984.1 - 0.027 14.0 0.1 6.8 6.1 0.0 3.1 3 0 0 3 3 3 0 Tti2 family RTP1_C1 PF10363.9 CCF38984.1 - 0.064 13.4 1.2 1.2 9.4 0.0 3.6 4 0 0 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 DUF2659 PF10858.8 CCF38984.1 - 0.11 12.1 0.3 0.21 11.2 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2659) Glyco_hydro_cc PF11790.8 CCF38986.1 - 3.5e-17 62.8 0.0 4.1e-17 62.6 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core MFS_1 PF07690.16 CCF38987.1 - 2.2e-20 72.9 35.4 9.8e-11 41.2 8.7 3.2 3 0 0 3 3 3 3 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF38987.1 - 0.012 14.5 1.8 0.012 14.5 1.8 3.6 4 0 0 4 4 4 0 Sugar (and other) transporter LacY_symp PF01306.19 CCF38987.1 - 7.5 5.2 15.5 0.067 12.0 5.0 2.5 3 0 0 3 3 3 0 LacY proton/sugar symporter adh_short PF00106.25 CCF38992.1 - 2.3e-24 86.0 0.5 4.1e-21 75.3 0.9 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCF38992.1 - 1.1e-13 51.3 0.2 3.2e-12 46.5 0.6 2.1 1 1 1 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF38992.1 - 1.6e-09 37.9 0.2 2.5e-09 37.3 0.2 1.3 1 0 0 1 1 1 1 KR domain Aldo_ket_red PF00248.21 CCF38993.1 - 4.1e-62 210.0 0.0 5.9e-62 209.5 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family Zn_clus PF00172.18 CCF38994.1 - 2.4e-10 40.4 8.1 4.1e-10 39.6 8.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 CCF38994.1 - 5.9e-08 31.9 0.0 8.7e-08 31.4 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain FAD_binding_4 PF01565.23 CCF38995.1 - 7.7e-17 61.3 4.1 4.4e-16 58.9 4.1 2.2 1 1 0 1 1 1 1 FAD binding domain BBE PF08031.12 CCF38995.1 - 4e-09 36.4 0.0 6.6e-09 35.7 0.0 1.4 1 0 0 1 1 1 1 Berberine and berberine like Methyltransf_11 PF08241.12 CCF38996.1 - 1.2e-08 35.5 0.1 1.9e-08 34.8 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF38996.1 - 5.1e-08 33.5 0.1 1.2e-07 32.4 0.1 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF38996.1 - 4.7e-05 23.2 0.0 6.3e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF38996.1 - 0.0003 21.5 0.0 0.00042 21.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 CCF38996.1 - 0.0019 17.4 0.0 0.0027 16.9 0.0 1.2 1 0 0 1 1 1 1 NNMT/PNMT/TEMT family Methyltransf_23 PF13489.6 CCF38996.1 - 0.017 15.0 0.0 0.026 14.4 0.0 1.3 1 1 0 1 1 1 0 Methyltransferase domain STAS_2 PF13466.6 CCF38996.1 - 0.064 13.6 0.3 0.15 12.4 0.3 1.6 1 0 0 1 1 1 0 STAS domain FAD_binding_3 PF01494.19 CCF38997.1 - 3.4e-21 75.9 0.0 4.8e-21 75.4 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 CCF38997.1 - 5.5e-06 26.2 4.4 0.0017 18.0 1.5 2.2 1 1 1 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCF38997.1 - 1.6e-05 24.3 0.2 0.00047 19.5 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCF38997.1 - 0.00087 19.5 0.2 0.0023 18.1 0.2 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain SE PF08491.10 CCF38997.1 - 0.025 13.6 0.0 0.069 12.2 0.0 1.6 2 0 0 2 2 2 0 Squalene epoxidase Pyr_redox PF00070.27 CCF38997.1 - 0.052 14.1 0.1 0.16 12.5 0.1 2.0 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CCF38997.1 - 0.052 12.2 0.1 0.074 11.7 0.1 1.1 1 0 0 1 1 1 0 HI0933-like protein NAD_binding_9 PF13454.6 CCF38997.1 - 0.065 13.2 0.4 1.4 8.9 0.3 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 CCF38997.1 - 0.067 12.3 0.3 0.11 11.6 0.3 1.3 1 0 0 1 1 1 0 FAD binding domain GIDA PF01134.22 CCF38997.1 - 0.077 12.1 0.0 0.1 11.6 0.0 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A FmiP_Thoc5 PF09766.9 CCF38998.1 - 8.4e-31 107.6 5.9 1.2e-30 107.0 5.9 1.2 1 0 0 1 1 1 1 Fms-interacting protein/Thoc5 HD_3 PF13023.6 CCF38998.1 - 0.033 14.1 0.2 0.033 14.1 0.2 1.7 2 0 0 2 2 2 0 HD domain SPATA1_C PF15743.5 CCF38998.1 - 0.1 12.7 9.2 0.14 12.3 1.8 2.3 2 1 0 2 2 2 0 Spermatogenesis-associated C-terminus DUF1664 PF07889.12 CCF38998.1 - 0.12 12.4 2.8 1.7 8.7 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Laminin_II PF06009.12 CCF38998.1 - 0.12 12.4 3.5 0.074 13.1 0.4 2.1 2 0 0 2 2 2 0 Laminin Domain II Casc1_N PF15927.5 CCF38998.1 - 0.31 10.7 12.9 0.27 10.9 4.2 2.6 2 1 1 3 3 3 0 Cancer susceptibility candidate 1 N-terminus V_ATPase_I PF01496.19 CCF38998.1 - 0.85 7.5 2.8 0.96 7.3 2.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF3450 PF11932.8 CCF38998.1 - 1.3 8.3 12.0 0.46 9.7 4.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) YabA PF06156.13 CCF38998.1 - 9.9 6.9 9.0 6.5 7.5 1.8 2.2 2 0 0 2 2 2 0 Initiation control protein YabA Kelch_6 PF13964.6 CCF39000.1 - 0.078 13.3 0.0 0.24 11.7 0.0 1.9 1 0 0 1 1 1 0 Kelch motif Kelch_5 PF13854.6 CCF39002.1 - 1.6e-11 43.9 0.6 1.6e-11 43.9 0.6 3.1 4 0 0 4 4 4 1 Kelch motif Kelch_4 PF13418.6 CCF39002.1 - 0.00067 19.6 1.2 0.22 11.5 0.0 4.0 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_3 PF13415.6 CCF39002.1 - 0.0019 18.5 3.7 0.0036 17.5 0.1 3.6 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_1 PF01344.25 CCF39002.1 - 0.0025 17.3 4.1 0.3 10.7 0.6 4.0 4 0 0 4 4 4 1 Kelch motif stn_TNFRSF12A PF12191.8 CCF39002.1 - 0.0054 16.9 0.5 0.011 15.9 0.5 1.5 1 0 0 1 1 1 1 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain Kelch_6 PF13964.6 CCF39002.1 - 0.055 13.8 4.0 0.15 12.4 0.1 3.5 4 1 0 4 4 4 0 Kelch motif Kelch_2 PF07646.15 CCF39002.1 - 1.3 9.2 6.7 30 4.8 0.3 4.3 6 0 0 6 6 6 0 Kelch motif PTP_tm PF18861.1 CCF39002.1 - 1.9 8.4 3.7 1.7 8.6 1.7 1.9 2 0 0 2 2 2 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J Glyco_hydro_3 PF00933.21 CCF39003.1 - 9.5e-43 146.8 0.0 1.2e-42 146.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fungal_trans PF04082.18 CCF39004.1 - 1.7e-13 50.2 0.9 2.4e-12 46.5 0.1 2.8 2 1 0 2 2 2 1 Fungal specific transcription factor domain 2OG-FeII_Oxy_3 PF13640.6 CCF39006.1 - 1.4e-09 38.7 0.1 2.7e-09 37.8 0.1 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Peptidase_M35 PF02102.15 CCF39007.1 - 6.3e-11 41.7 0.1 6.7e-11 41.7 0.1 1.0 1 0 0 1 1 1 1 Deuterolysin metalloprotease (M35) family Nop14 PF04147.12 CCF39008.1 - 0.029 12.6 7.8 0.033 12.4 7.8 1.0 1 0 0 1 1 1 0 Nop14-like family FAM176 PF14851.6 CCF39008.1 - 0.35 10.5 5.8 0.51 10.0 5.8 1.3 1 0 0 1 1 1 0 FAM176 family CDC45 PF02724.14 CCF39008.1 - 0.54 8.5 8.7 0.65 8.2 8.7 1.0 1 0 0 1 1 1 0 CDC45-like protein NOA36 PF06524.12 CCF39008.1 - 1.1 8.5 13.2 1.3 8.2 13.2 1.2 1 0 0 1 1 1 0 NOA36 protein SDA1 PF05285.12 CCF39008.1 - 1.6 8.1 14.9 2 7.8 14.9 1.0 1 0 0 1 1 1 0 SDA1 RRN3 PF05327.11 CCF39008.1 - 3.6 6.0 8.6 4 5.9 8.6 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Fungal_trans_2 PF11951.8 CCF39009.1 - 6.6e-21 74.5 0.0 7.9e-21 74.3 0.0 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF4632 PF15451.6 CCF39009.1 - 2.3 8.3 4.6 8.5 6.5 0.1 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4632) HET PF06985.11 CCF39012.1 - 1.9e-26 93.1 0.0 3.2e-26 92.4 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) YbjN PF10722.9 CCF39012.1 - 0.046 13.8 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 Putative bacterial sensory transduction regulator DUF3328 PF11807.8 CCF39013.1 - 1.1e-18 67.9 4.9 1.6e-18 67.3 4.9 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) DUF3328 PF11807.8 CCF39014.1 - 5.4e-30 104.8 2.1 7.9e-30 104.3 2.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) MFS_1 PF07690.16 CCF39015.1 - 2.7e-23 82.5 26.1 4.8e-23 81.7 22.4 2.6 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 CCF39015.1 - 2e-09 36.5 1.0 2.8e-09 36.0 1.0 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 CCF39015.1 - 0.051 12.4 11.1 0.028 13.3 2.2 2.2 2 0 0 2 2 2 0 Sugar (and other) transporter HET PF06985.11 CCF39016.1 - 1.7e-19 70.6 0.0 5.9e-19 68.9 0.0 1.9 2 0 0 2 2 2 1 Heterokaryon incompatibility protein (HET) Fungal_trans_2 PF11951.8 CCF39017.1 - 1e-07 31.1 0.0 2.1e-07 30.1 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF39017.1 - 4.8e-06 26.6 10.0 1.2e-05 25.3 10.0 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sugar_tr PF00083.24 CCF39018.1 - 1.2e-118 396.8 20.9 1.4e-118 396.6 20.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF39018.1 - 5.5e-24 84.7 21.3 5.5e-24 84.7 21.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily COesterase PF00135.28 CCF39019.1 - 2.6e-83 280.6 0.0 3.4e-83 280.2 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CCF39019.1 - 0.0035 17.2 0.1 0.014 15.2 0.1 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Pec_lyase_C PF00544.19 CCF39020.1 - 2e-29 102.7 4.7 2.8e-29 102.2 4.7 1.2 1 0 0 1 1 1 1 Pectate lyase Beta_helix PF13229.6 CCF39020.1 - 0.0021 17.9 2.0 0.023 14.6 2.0 2.1 1 1 0 1 1 1 1 Right handed beta helix region VSP PF03302.13 CCF39021.1 - 0.00014 20.9 0.1 0.0002 20.3 0.1 1.2 1 0 0 1 1 1 1 Giardia variant-specific surface protein Podoplanin PF05808.11 CCF39021.1 - 0.00062 19.9 0.2 0.00062 19.9 0.2 2.6 2 1 0 3 3 3 1 Podoplanin DUF4690 PF15756.5 CCF39021.1 - 0.014 16.0 0.7 0.061 13.9 0.1 2.4 2 0 0 2 2 2 0 Small Novel Rich in Cartilage Yip1 PF04893.17 CCF39021.1 - 0.025 14.3 0.2 0.037 13.7 0.2 1.2 1 0 0 1 1 1 0 Yip1 domain Amnionless PF14828.6 CCF39021.1 - 0.042 12.7 0.0 0.062 12.1 0.0 1.3 1 0 0 1 1 1 0 Amnionless MGC-24 PF05283.11 CCF39021.1 - 0.08 13.4 0.5 0.44 11.0 0.0 2.3 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Syndecan PF01034.20 CCF39021.1 - 0.14 12.1 0.1 0.25 11.3 0.1 1.3 1 0 0 1 1 1 0 Syndecan domain MtrF PF09472.10 CCF39021.1 - 1.1 8.7 2.7 2.3 7.7 2.7 1.4 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) DUF846 PF05832.12 CCF39022.1 - 1.8e-51 173.8 10.8 2.2e-51 173.6 10.8 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) DUF4870 PF09685.10 CCF39022.1 - 0.63 10.2 12.2 0.2 11.8 0.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4870) Pex24p PF06398.11 CCF39022.1 - 8.2 5.3 11.1 7.1 5.5 1.2 2.1 2 0 0 2 2 2 0 Integral peroxisomal membrane peroxin MRP-S26 PF14943.6 CCF39023.1 - 2.6 7.9 18.5 0.57 10.1 8.0 2.4 2 0 0 2 2 2 0 Mitochondrial ribosome subunit S26 Mago_nashi PF02792.14 CCF39024.1 - 1e-72 242.9 0.1 1.1e-72 242.7 0.1 1.0 1 0 0 1 1 1 1 Mago nashi protein RXT2_N PF08595.11 CCF39025.1 - 8.9e-34 116.8 0.0 8.9e-34 116.8 0.0 2.5 3 0 0 3 3 3 1 RXT2-like, N-terminal PEMT PF04191.13 CCF39026.1 - 3.1e-34 117.6 4.1 1.1e-33 115.7 3.2 1.9 2 0 0 2 2 2 1 Phospholipid methyltransferase Methyltransf_23 PF13489.6 CCF39028.1 - 6.3e-14 52.1 0.0 9.4e-14 51.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF39028.1 - 4.2e-09 37.0 0.0 9.3e-09 35.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF39028.1 - 2e-07 30.9 0.0 5.4e-07 29.5 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF39028.1 - 4e-07 30.6 0.0 8.1e-07 29.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF39028.1 - 4.2e-07 30.6 0.0 2.2e-06 28.3 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 CCF39028.1 - 0.00015 21.3 0.0 0.002 17.6 0.0 2.3 2 0 0 2 2 2 1 Putative methyltransferase Ubie_methyltran PF01209.18 CCF39028.1 - 0.00076 18.9 0.0 0.035 13.4 0.0 2.5 2 1 0 2 2 2 1 ubiE/COQ5 methyltransferase family PrmA PF06325.13 CCF39028.1 - 0.00097 18.6 0.0 0.0021 17.5 0.0 1.5 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 CCF39028.1 - 0.0039 16.8 0.0 0.009 15.6 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_2 PF00891.18 CCF39028.1 - 0.0081 15.5 0.0 0.013 14.8 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain CMAS PF02353.20 CCF39028.1 - 0.032 13.5 0.0 0.053 12.8 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_16 PF10294.9 CCF39028.1 - 0.07 12.9 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase GidB PF02527.15 CCF39028.1 - 0.098 12.0 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G UPF0146 PF03686.13 CCF39028.1 - 0.13 12.1 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0146) PBP PF01161.20 CCF39031.1 - 3.4e-16 59.8 0.0 4.4e-16 59.4 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein MdcE PF06833.11 CCF39031.1 - 0.019 14.5 0.2 0.031 13.8 0.2 1.2 1 0 0 1 1 1 0 Malonate decarboxylase gamma subunit (MdcE) ADH_zinc_N PF00107.26 CCF39033.1 - 1.6e-12 47.5 0.0 2.5e-12 46.9 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCF39033.1 - 4e-05 23.5 0.0 7.1e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 CCF39033.1 - 0.00082 20.4 0.0 0.0014 19.6 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase TraB PF01963.17 CCF39033.1 - 0.17 11.8 0.0 0.25 11.2 0.0 1.2 1 0 0 1 1 1 0 TraB family Sugar_tr PF00083.24 CCF39034.1 - 8.8e-43 146.8 5.9 1e-42 146.6 5.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter Amidase PF01425.21 CCF39035.1 - 2e-70 238.0 0.2 9e-68 229.3 0.0 2.1 2 0 0 2 2 2 2 Amidase Defensin_like PF10868.8 CCF39036.1 - 0.047 14.5 13.1 0.067 14.0 13.1 1.3 1 0 0 1 1 1 0 Cysteine-rich antifungal protein 2, defensin-like p450 PF00067.22 CCF39037.1 - 5.1e-29 101.3 0.0 2.1e-18 66.4 0.0 2.4 2 1 0 2 2 2 2 Cytochrome P450 ImcF-related_N PF14331.6 CCF39037.1 - 0.011 15.1 0.1 0.15 11.4 0.0 2.2 2 0 0 2 2 2 0 ImcF-related N-terminal domain Trp_DMAT PF11991.8 CCF39038.1 - 3e-96 323.0 0.0 3.6e-96 322.7 0.0 1.1 1 0 0 1 1 1 1 Tryptophan dimethylallyltransferase p450 PF00067.22 CCF39039.1 - 1.2e-14 54.0 0.0 1.7e-14 53.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Kei1 PF08552.11 CCF39040.1 - 6e-59 199.1 3.3 9.3e-59 198.5 3.3 1.3 1 0 0 1 1 1 1 Inositolphosphorylceramide synthase subunit Kei1 SPC12 PF06645.13 CCF39040.1 - 0.024 14.7 2.5 0.024 14.7 2.5 2.0 2 1 0 2 2 2 0 Microsomal signal peptidase 12 kDa subunit (SPC12) DUF2975 PF11188.8 CCF39040.1 - 0.047 13.6 1.3 0.21 11.5 0.6 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF2975) Ras PF00071.22 CCF39041.1 - 1.2e-59 200.5 0.5 1.6e-59 200.2 0.5 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCF39041.1 - 1.5e-37 128.5 0.1 2.5e-37 127.7 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCF39041.1 - 3.1e-18 65.8 0.3 3.8e-18 65.5 0.3 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 CCF39041.1 - 4.8e-07 29.5 0.2 3e-06 26.9 0.2 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 CCF39041.1 - 7.6e-06 25.5 0.1 1.4e-05 24.7 0.1 1.4 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 CCF39041.1 - 1.5e-05 25.0 0.1 3.3e-05 23.9 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 CCF39041.1 - 1.9e-05 24.2 0.5 2.4e-05 23.8 0.5 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 CCF39041.1 - 0.00011 22.2 0.1 0.069 13.1 0.1 2.2 2 0 0 2 2 2 2 RsgA GTPase ATP_bind_1 PF03029.17 CCF39041.1 - 0.0043 16.9 0.2 0.013 15.3 0.0 1.6 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein FlgH PF02107.16 CCF39041.1 - 0.034 13.7 0.9 0.047 13.3 0.9 1.2 1 0 0 1 1 1 0 Flagellar L-ring protein TIR_2 PF13676.6 CCF39041.1 - 0.055 14.1 0.1 0.1 13.2 0.1 1.4 1 0 0 1 1 1 0 TIR domain AAA_28 PF13521.6 CCF39041.1 - 0.092 13.0 0.1 4.3 7.5 0.1 2.2 1 1 0 1 1 1 0 AAA domain TetR_C_16 PF17920.1 CCF39041.1 - 0.12 12.6 0.0 0.89 9.8 0.0 2.0 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Nop53 PF07767.11 CCF39042.1 - 3.1e-60 204.7 4.0 3.4e-60 204.5 4.0 1.0 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) His_Phos_1 PF00300.22 CCF39043.1 - 2e-13 50.5 0.1 4.1e-13 49.5 0.1 1.4 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) DUF2235 PF09994.9 CCF39044.1 - 6.4e-78 262.0 0.0 1.7e-76 257.4 0.0 2.1 1 1 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) DUF155 PF02582.14 CCF39046.1 - 3.3e-53 180.4 0.5 4.7e-53 179.9 0.5 1.2 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 HMG_box PF00505.19 CCF39047.1 - 9.5e-11 42.0 0.4 2.6e-10 40.6 0.3 1.8 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 CCF39047.1 - 1.4e-05 25.6 0.6 1.4e-05 25.6 0.6 2.4 3 0 0 3 3 3 1 HMG-box domain CCDC106 PF15794.5 CCF39047.1 - 0.0078 16.0 0.6 0.0078 16.0 0.6 2.2 2 0 0 2 2 2 1 Coiled-coil domain-containing protein 106 HAUS4 PF14735.6 CCF39047.1 - 0.029 14.1 0.0 0.047 13.4 0.0 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 4 SlyX PF04102.12 CCF39047.1 - 3 8.5 7.8 0.77 10.4 0.2 3.0 2 1 1 3 3 3 0 SlyX LRR_4 PF12799.7 CCF39048.1 - 1.8e-26 91.7 36.1 2.1e-05 24.8 4.4 8.9 3 1 9 12 12 12 9 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCF39048.1 - 7.2e-20 70.5 55.3 1.1e-08 34.8 0.5 7.5 2 2 6 9 9 9 8 Leucine rich repeat LRR_9 PF14580.6 CCF39048.1 - 2.4e-08 33.7 14.5 0.02 14.4 0.5 5.4 1 1 4 5 5 5 5 Leucine-rich repeat LRR_6 PF13516.6 CCF39048.1 - 4.9e-07 29.3 16.6 4.4 7.6 0.1 8.3 8 0 0 8 8 8 4 Leucine Rich repeat LRR_1 PF00560.33 CCF39048.1 - 0.0015 18.8 20.8 19 6.3 0.5 9.7 10 1 0 10 10 10 1 Leucine Rich Repeat NMT1 PF09084.11 CCF39049.1 - 0.0038 17.2 0.0 0.024 14.6 0.0 2.1 1 1 1 2 2 2 1 NMT1/THI5 like SBP_bac_3 PF00497.20 CCF39049.1 - 0.012 15.1 0.0 0.041 13.3 0.0 2.0 1 1 0 1 1 1 0 Bacterial extracellular solute-binding proteins, family 3 CTP_transf_like PF01467.26 CCF39050.1 - 8.5e-08 32.5 0.2 1e-06 29.0 0.2 2.5 1 1 0 1 1 1 1 Cytidylyltransferase-like WLM PF08325.10 CCF39051.1 - 3.1e-56 190.5 0.0 6.9e-56 189.4 0.0 1.6 1 0 0 1 1 1 1 WLM domain zf-RanBP PF00641.18 CCF39051.1 - 0.0001 21.6 2.7 0.00021 20.6 2.7 1.5 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Peptidase_M54 PF07998.11 CCF39051.1 - 0.19 11.7 0.0 0.27 11.2 0.0 1.1 1 0 0 1 1 1 0 Peptidase family M54 KR PF08659.10 CCF39052.1 - 3.2e-16 59.8 0.0 8.2e-16 58.4 0.0 1.7 2 0 0 2 2 2 1 KR domain Thymidylat_synt PF00303.19 CCF39053.1 - 9.4e-110 365.9 0.0 1.1e-109 365.8 0.0 1.0 1 0 0 1 1 1 1 Thymidylate synthase HTH_ABP1_N PF18107.1 CCF39054.1 - 2.4e-24 84.8 2.2 7.2e-24 83.3 2.2 1.8 1 0 0 1 1 1 1 Fission yeast centromere protein N-terminal domain HTH_Tnp_Tc5 PF03221.16 CCF39054.1 - 1.4e-17 63.5 1.7 8.8e-17 60.9 0.2 2.6 2 1 1 3 3 3 1 Tc5 transposase DNA-binding domain DUF4604 PF15377.6 CCF39054.1 - 0.012 16.0 0.2 0.023 15.1 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) MFS_1 PF07690.16 CCF39057.1 - 5.1e-34 117.8 26.8 5.1e-34 117.8 26.8 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily BT1 PF03092.16 CCF39057.1 - 0.02 13.2 3.2 0.032 12.5 1.0 2.0 2 0 0 2 2 2 0 BT1 family Ribonuc_L-PSP PF01042.21 CCF39058.1 - 8.4e-39 132.3 0.0 9.2e-39 132.2 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP Pirin PF02678.16 CCF39058.1 - 0.099 12.6 0.0 0.13 12.3 0.0 1.2 1 0 0 1 1 1 0 Pirin Abhydrolase_3 PF07859.13 CCF39059.1 - 8.2e-54 182.7 0.2 1.7e-53 181.6 0.2 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CCF39059.1 - 5.3e-05 22.8 0.0 0.00011 21.8 0.0 1.4 1 1 0 1 1 1 1 Prolyl oligopeptidase family COesterase PF00135.28 CCF39059.1 - 0.087 11.7 0.6 2 7.2 0.0 2.1 1 1 0 2 2 2 0 Carboxylesterase family p450 PF00067.22 CCF39060.1 - 9.2e-63 212.6 0.0 1e-62 212.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Sulfotransfer_4 PF17784.1 CCF39062.1 - 1.6e-35 122.9 0.0 1.7e-35 122.8 0.0 1.0 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 CCF39062.1 - 0.0043 17.5 0.1 0.012 16.0 0.1 1.9 1 1 0 1 1 1 1 Sulfotransferase family WD40 PF00400.32 CCF39063.1 - 5.3e-17 61.9 8.7 0.00035 21.3 0.1 5.9 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF39063.1 - 2.4e-06 27.7 0.0 0.097 13.0 0.0 4.1 1 1 4 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 CCF39063.1 - 0.00025 20.5 0.0 0.00057 19.3 0.0 1.6 1 0 0 1 1 1 1 WD40-like domain Ge1_WD40 PF16529.5 CCF39063.1 - 0.095 11.6 0.3 5.5 5.8 0.0 2.8 2 1 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 CCF39063.1 - 0.11 11.1 0.1 5.3 5.6 0.0 2.2 2 0 0 2 2 2 0 Nucleoporin Nup120/160 HHV-1_VABD PF16852.5 CCF39064.1 - 3.8 7.6 5.8 0.76 9.8 1.4 2.1 2 0 0 2 2 2 0 Herpes viral adaptor-to-host cellular mRNA binding domain LEA_4 PF02987.16 CCF39067.1 - 0.0031 17.6 4.3 0.0031 17.6 4.3 3.2 2 1 0 3 3 3 2 Late embryogenesis abundant protein Herpes_UL17 PF04559.12 CCF39067.1 - 3.3 6.4 7.5 3.6 6.3 7.5 1.0 1 0 0 1 1 1 0 Herpesvirus UL17 protein ALMT PF11744.8 CCF39067.1 - 6.1 5.5 8.6 7 5.4 8.6 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Atg14 PF10186.9 CCF39067.1 - 8.7 5.3 18.0 10 5.1 18.0 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 TPP_enzyme_N PF02776.18 CCF39068.1 - 1.3e-34 119.3 1.5 2.4e-34 118.4 0.7 1.8 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 CCF39068.1 - 5.2e-18 65.3 0.0 1.3e-16 60.8 0.0 2.5 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 CCF39068.1 - 1.2e-17 63.9 0.0 2.9e-17 62.7 0.0 1.7 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain FSA_C PF10479.9 CCF39070.1 - 0.59 8.2 2.4 0.8 7.8 2.4 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus zf-RING_2 PF13639.6 CCF39071.1 - 1.4e-12 47.7 5.1 2.3e-12 47.0 5.1 1.3 1 0 0 1 1 1 1 Ring finger domain PA PF02225.22 CCF39071.1 - 2e-10 40.5 0.0 5.5e-10 39.1 0.0 1.7 1 0 0 1 1 1 1 PA domain zf-C3HC4_2 PF13923.6 CCF39071.1 - 2.4e-09 36.9 3.9 3.8e-09 36.2 3.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 CCF39071.1 - 6.9e-09 35.9 2.1 1.4e-08 34.9 2.1 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 CCF39071.1 - 1.3e-08 34.6 3.1 2.1e-08 33.9 3.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 CCF39071.1 - 3.4e-08 33.1 2.2 3.4e-08 33.1 2.2 1.8 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_5 PF14634.6 CCF39071.1 - 6.1e-07 29.3 2.4 9.4e-07 28.7 2.4 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 CCF39071.1 - 5.3e-06 26.3 1.7 5.2e-05 23.2 2.4 2.2 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 CCF39071.1 - 9.5e-06 25.4 2.9 1.4e-05 24.8 2.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 CCF39071.1 - 0.0012 18.8 0.7 0.0022 18.0 0.7 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 CCF39071.1 - 0.0063 16.4 2.6 0.011 15.6 2.6 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 CCF39071.1 - 0.05 13.8 3.5 0.16 12.1 3.6 1.8 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING Zn_ribbon_17 PF17120.5 CCF39071.1 - 0.064 12.9 3.0 0.13 12.0 3.0 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type FANCL_C PF11793.8 CCF39071.1 - 0.11 12.7 2.4 0.26 11.5 2.4 1.7 1 1 0 1 1 1 0 FANCL C-terminal domain RINGv PF12906.7 CCF39071.1 - 0.19 11.9 2.4 0.4 10.9 2.4 1.6 1 1 0 1 1 1 0 RING-variant domain PHD PF00628.29 CCF39071.1 - 1.1 9.2 2.4 1.9 8.4 2.4 1.4 1 0 0 1 1 1 0 PHD-finger zf-RING-like PF08746.11 CCF39071.1 - 1.3 9.4 3.2 2.2 8.7 3.2 1.4 1 0 0 1 1 1 0 RING-like domain DUF4083 PF13314.6 CCF39071.1 - 7.9 6.5 5.1 18 5.4 0.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4083) MFS_1 PF07690.16 CCF39072.1 - 1.5e-39 135.9 26.0 2.4e-39 135.3 26.0 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily HupE_UreJ PF04955.12 CCF39072.1 - 0.0033 16.9 2.9 0.0033 16.9 2.9 2.1 2 1 0 2 2 2 1 HupE / UreJ protein Fungal_trans PF04082.18 CCF39073.1 - 1e-15 57.5 0.0 1.5e-15 56.9 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF39073.1 - 7.2e-08 32.4 8.4 7.2e-08 32.4 8.4 1.6 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CCF39074.1 - 4.4e-16 58.7 2.0 7.1e-16 58.0 2.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-H2C2_2 PF13465.6 CCF39074.1 - 1.1e-07 32.0 13.4 1.1e-05 25.6 5.8 3.1 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2 PF00096.26 CCF39074.1 - 0.00072 19.9 14.6 0.039 14.4 5.3 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_3rep PF18868.1 CCF39074.1 - 0.033 14.8 0.8 3.1 8.5 0.1 2.7 2 1 1 3 3 3 0 Zinc finger C2H2-type, 3 repeats DUF3541 PF12060.8 CCF39074.1 - 0.084 12.6 0.2 0.15 11.8 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3541) Zn-ribbon_8 PF09723.10 CCF39074.1 - 1.3 9.2 4.1 4.1 7.6 4.1 1.9 1 0 0 1 1 1 0 Zinc ribbon domain RhgB_N PF09284.10 CCF39075.1 - 2.3e-75 253.4 0.8 3.2e-75 252.9 0.8 1.2 1 0 0 1 1 1 1 Rhamnogalacturonan lyase B, N-terminal CBM-like PF14683.6 CCF39075.1 - 3.3e-34 118.2 0.4 1.2e-33 116.3 0.1 2.2 2 0 0 2 2 2 1 Polysaccharide lyase family 4, domain III fn3_3 PF14686.6 CCF39075.1 - 6.9e-17 61.0 4.2 2.2e-16 59.4 4.2 1.9 1 0 0 1 1 1 1 Polysaccharide lyase family 4, domain II CarboxypepD_reg PF13620.6 CCF39075.1 - 0.00065 19.9 2.6 0.00079 19.7 0.4 2.1 2 0 0 2 2 2 1 Carboxypeptidase regulatory-like domain Cupin_5 PF06172.11 CCF39075.1 - 0.032 14.4 0.0 0.065 13.4 0.0 1.6 1 0 0 1 1 1 0 Cupin superfamily (DUF985) An_peroxidase PF03098.15 CCF39076.1 - 1.4e-40 139.4 0.0 2.9e-28 98.8 0.0 3.2 1 1 1 2 2 2 2 Animal haem peroxidase p450 PF00067.22 CCF39076.1 - 0.001 17.9 0.1 0.082 11.6 0.0 2.7 2 1 0 2 2 2 1 Cytochrome P450 NOC3p PF07540.11 CCF39078.1 - 6.4e-29 100.3 4.3 7e-29 100.1 0.4 2.9 3 0 0 3 3 3 1 Nucleolar complex-associated protein CBF PF03914.17 CCF39078.1 - 5.7e-26 91.6 2.0 9.4e-26 90.9 1.0 1.9 2 0 0 2 2 2 1 CBF/Mak21 family RRN3 PF05327.11 CCF39078.1 - 0.02 13.4 0.1 0.02 13.4 0.1 2.6 2 1 0 3 3 3 0 RNA polymerase I specific transcription initiation factor RRN3 UPF0113_N PF17833.1 CCF39079.1 - 7e-26 90.6 0.0 9.5e-26 90.2 0.0 1.2 1 0 0 1 1 1 1 UPF0113 Pre-PUA domain UPF0113 PF03657.13 CCF39079.1 - 4.1e-25 87.9 0.0 1.9e-24 85.7 0.0 1.9 2 0 0 2 2 2 1 UPF0113 PUA domain AA_kinase PF00696.28 CCF39080.1 - 2.5e-39 135.3 1.2 3.5e-39 134.9 1.2 1.2 1 0 0 1 1 1 1 Amino acid kinase family PUA PF01472.20 CCF39080.1 - 6.8e-14 51.6 0.2 5.7e-13 48.6 0.0 2.4 2 0 0 2 2 2 1 PUA domain Peptidase_M76 PF09768.9 CCF39081.1 - 5.1e-68 228.2 1.3 6.4e-68 227.9 1.3 1.1 1 0 0 1 1 1 1 Peptidase M76 family SprT-like PF10263.9 CCF39081.1 - 0.017 14.9 2.0 0.09 12.6 0.6 2.2 1 1 1 2 2 2 0 SprT-like family Peptidase_M91 PF14891.6 CCF39081.1 - 0.1 12.9 0.1 0.17 12.2 0.1 1.4 1 0 0 1 1 1 0 Effector protein DUF3123 PF11321.8 CCF39081.1 - 2.3 8.9 4.0 4.2 8.1 4.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3123) Pkinase PF00069.25 CCF39082.1 - 1.3e-58 198.5 0.0 4e-52 177.2 0.0 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCF39082.1 - 6.8e-34 117.3 0.0 1.2e-31 109.9 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF39082.1 - 1.3e-06 28.0 0.0 3.3e-06 26.6 0.0 1.6 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 CCF39082.1 - 0.00059 19.3 0.2 0.0009 18.6 0.2 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 CCF39082.1 - 0.023 14.2 0.2 0.26 10.8 0.0 2.1 1 1 1 2 2 2 0 PhoP regulatory network protein YrbL RIO1 PF01163.22 CCF39082.1 - 0.028 14.0 0.0 0.077 12.6 0.0 1.7 1 1 1 2 2 2 0 RIO1 family Haspin_kinase PF12330.8 CCF39082.1 - 0.039 12.9 5.4 0.07 12.1 0.0 2.1 2 0 0 2 2 2 0 Haspin like kinase domain FTA2 PF13095.6 CCF39082.1 - 0.074 12.7 0.1 0.18 11.4 0.0 1.6 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 CCF39082.1 - 0.11 11.2 1.3 0.18 10.5 1.3 1.4 1 1 0 1 1 1 0 Fungal protein kinase APH PF01636.23 CCF39082.1 - 0.18 11.7 0.0 0.26 11.2 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Peptidase_S8 PF00082.22 CCF39083.1 - 3.7e-11 42.9 0.1 5.1e-11 42.4 0.1 1.2 1 0 0 1 1 1 1 Subtilase family BRX PF08381.11 CCF39085.1 - 0.1 12.0 0.4 0.17 11.2 0.4 1.3 1 0 0 1 1 1 0 Transcription factor regulating root and shoot growth via Pin3 Glyco_hydro_3_C PF01915.22 CCF39086.1 - 5.2e-49 167.0 0.0 8.2e-49 166.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 CCF39086.1 - 1.7e-24 85.7 0.2 3.2e-24 84.8 0.2 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain Glyco_hydro_3 PF00933.21 CCF39086.1 - 3.1e-22 79.4 0.0 5.4e-22 78.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain fn3_5 PF06280.12 CCF39087.1 - 0.02 15.6 0.0 0.044 14.5 0.0 1.6 2 0 0 2 2 2 0 Fn3-like domain Nodulin-like PF06813.13 CCF39088.1 - 7.5e-05 22.3 4.2 0.006 16.1 0.1 3.0 3 1 0 3 3 3 2 Nodulin-like HEV_ORF1 PF02444.16 CCF39088.1 - 6.5 7.4 6.2 35 5.0 0.6 3.6 4 0 0 4 4 4 0 Hepatitis E virus ORF-2 (Putative capsid protein) ECH_1 PF00378.20 CCF39091.1 - 3.1e-25 89.0 0.0 4e-25 88.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CCF39091.1 - 1.3e-13 51.2 0.0 1.5e-13 51.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Vps51 PF08700.11 CCF39092.1 - 1.3e-13 50.8 0.0 5.2e-13 48.9 0.0 2.0 1 0 0 1 1 1 1 Vps51/Vps67 DUF4054 PF13262.6 CCF39092.1 - 0.032 14.3 0.1 0.086 12.9 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF4054) CaMKII_AD PF08332.10 CCF39092.1 - 0.13 12.4 0.0 0.35 11.0 0.0 1.7 1 0 0 1 1 1 0 Calcium/calmodulin dependent protein kinase II association domain Menin PF05053.13 CCF39092.1 - 1.8 6.9 5.5 2.8 6.2 5.5 1.2 1 0 0 1 1 1 0 Menin REV1_C PF16727.5 CCF39092.1 - 2.9 8.3 5.3 0.83 10.1 0.3 2.8 3 0 0 3 3 3 0 DNA repair protein REV1 C-terminal domain RR_TM4-6 PF06459.12 CCF39092.1 - 4.6 7.0 10.2 9 6.0 10.2 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Aldedh PF00171.22 CCF39093.1 - 1e-85 288.0 0.3 1.2e-85 287.8 0.3 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Rhodanese PF00581.20 CCF39095.1 - 4.5e-13 49.7 0.0 9.3e-13 48.6 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain Methyltransf_31 PF13847.6 CCF39096.1 - 1.9e-28 99.2 0.0 2.7e-28 98.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF39096.1 - 8.7e-23 80.9 0.0 1.7e-22 79.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF39096.1 - 9.1e-20 71.1 0.0 1.9e-19 70.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCF39096.1 - 3.2e-16 59.4 0.0 5.2e-16 58.7 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 CCF39096.1 - 1.2e-09 38.2 0.0 1.8e-09 37.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF39096.1 - 1.4e-09 38.5 0.0 2.5e-09 37.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 CCF39096.1 - 7.8e-08 32.1 0.0 1.1e-07 31.5 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) PCMT PF01135.19 CCF39096.1 - 1e-06 28.6 0.0 2.4e-06 27.5 0.0 1.6 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 CCF39096.1 - 1.2e-05 25.0 0.0 2.1e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_2 PF00891.18 CCF39096.1 - 1.5e-05 24.4 0.0 2.1e-05 23.9 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_4 PF02390.17 CCF39096.1 - 1.9e-05 24.2 0.0 5.2e-05 22.8 0.0 1.7 1 1 0 1 1 1 1 Putative methyltransferase UPF0020 PF01170.18 CCF39096.1 - 2.1e-05 24.3 0.0 3.4e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_32 PF13679.6 CCF39096.1 - 0.0002 21.4 0.0 0.00032 20.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 CCF39096.1 - 0.0012 18.8 0.0 0.002 18.0 0.0 1.3 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_3 PF01596.17 CCF39096.1 - 0.0072 15.5 0.0 0.011 14.9 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase CMAS PF02353.20 CCF39096.1 - 0.0095 15.3 0.0 0.014 14.7 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase DOT1 PF08123.13 CCF39096.1 - 0.012 15.1 0.1 0.019 14.5 0.1 1.4 1 1 0 1 1 1 0 Histone methylation protein DOT1 Methyltransf_18 PF12847.7 CCF39096.1 - 0.032 14.2 0.0 0.053 13.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain FtsJ PF01728.19 CCF39096.1 - 0.04 14.0 0.0 0.081 13.0 0.0 1.4 1 1 0 1 1 1 0 FtsJ-like methyltransferase TehB PF03848.14 CCF39096.1 - 0.063 12.7 0.0 0.18 11.2 0.0 1.8 2 0 0 2 2 2 0 Tellurite resistance protein TehB Methyltransf_15 PF09445.10 CCF39096.1 - 0.078 12.5 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Sugar_tr PF00083.24 CCF39097.1 - 3.2e-84 283.4 22.9 3.6e-84 283.2 22.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF39097.1 - 6.2e-21 74.7 41.0 4.1e-16 58.8 30.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Fijivirus_P9-2 PF06837.11 CCF39097.1 - 0.13 11.7 0.2 0.29 10.6 0.2 1.5 1 0 0 1 1 1 0 Fijivirus P9-2 protein Acetyltransf_7 PF13508.7 CCF39098.1 - 4.2e-12 46.3 0.0 5.9e-12 45.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CCF39098.1 - 4.4e-12 46.3 0.0 5.7e-12 45.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CCF39098.1 - 1.5e-11 44.4 0.0 1.8e-11 44.0 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CCF39098.1 - 0.001 19.0 0.0 0.0024 17.8 0.0 1.6 2 0 0 2 2 2 1 FR47-like protein DUF4821 PF16092.5 CCF39098.1 - 0.0035 17.0 0.0 0.005 16.5 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4821) Acetyltransf_CG PF14542.6 CCF39098.1 - 0.076 13.2 0.0 0.15 12.2 0.0 1.5 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase RicinB_lectin_2 PF14200.6 CCF39099.1 - 4.4e-08 33.7 0.0 0.00019 22.1 0.0 2.0 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain-like VirK PF06903.12 CCF39099.1 - 0.051 13.7 0.0 3.1 7.9 0.0 2.1 2 0 0 2 2 2 0 VirK protein DUF4482 PF14818.6 CCF39100.1 - 0.054 14.4 6.4 0.097 13.5 6.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4482) dCache_2 PF08269.11 CCF39100.1 - 0.095 11.9 0.0 0.13 11.4 0.0 1.1 1 0 0 1 1 1 0 Cache domain YflT PF11181.8 CCF39100.1 - 0.27 11.8 0.8 0.51 10.9 0.8 1.3 1 0 0 1 1 1 0 Heat induced stress protein YflT SesA PF17107.5 CCF39101.1 - 4.2e-37 127.0 0.6 1.2e-36 125.5 0.2 1.8 2 0 0 2 2 2 1 N-terminal domain on NACHT_NTPase and P-loop NTPases Helo_like_N PF17111.5 CCF39101.1 - 0.00053 19.4 0.1 0.002 17.6 0.0 1.8 1 1 2 3 3 3 1 Fungal N-terminal domain of STAND proteins MnmE_helical PF12631.7 CCF39101.1 - 0.025 14.7 0.1 0.034 14.3 0.1 1.3 1 0 0 1 1 1 0 MnmE helical domain Ank_2 PF12796.7 CCF39102.1 - 4e-97 318.9 24.9 3.1e-15 56.5 0.3 9.0 1 1 8 10 10 10 10 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CCF39102.1 - 1.9e-79 261.1 12.7 8.2e-11 42.2 0.0 11.5 7 4 4 11 11 11 10 Ankyrin repeats (many copies) Ank PF00023.30 CCF39102.1 - 6.5e-73 238.2 16.3 7.6e-05 23.0 0.0 15.7 15 0 0 15 15 15 15 Ankyrin repeat Ank_3 PF13606.6 CCF39102.1 - 7.5e-68 216.4 6.4 0.00031 20.9 0.0 16.3 16 0 0 16 16 16 14 Ankyrin repeat Ank_5 PF13857.6 CCF39102.1 - 7.4e-67 220.5 16.1 7.6e-09 35.7 0.1 11.1 5 2 6 12 12 12 12 Ankyrin repeats (many copies) DUF2520 PF10728.9 CCF39102.1 - 0.0023 17.7 5.2 4.9 6.9 0.4 5.2 2 1 3 5 5 5 1 Domain of unknown function (DUF2520) DUF4265 PF14085.6 CCF39102.1 - 0.038 14.0 0.1 2.6 8.0 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4265) PD40 PF07676.12 CCF39105.1 - 0.025 14.5 0.0 0.053 13.5 0.0 1.5 1 0 0 1 1 1 0 WD40-like Beta Propeller Repeat SGL PF08450.12 CCF39105.1 - 0.04 13.5 0.0 0.07 12.7 0.0 1.4 1 0 0 1 1 1 0 SMP-30/Gluconolactonase/LRE-like region WD40 PF00400.32 CCF39106.1 - 1.1e-24 86.2 22.6 1.2e-05 25.9 0.2 7.0 6 2 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF39106.1 - 6.2e-14 52.1 5.3 9.8e-06 25.8 0.0 4.1 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain TFIIIC_delta PF12657.7 CCF39106.1 - 1.8e-06 28.0 7.7 0.0047 16.9 0.2 3.0 2 2 0 2 2 2 2 Transcription factor IIIC subunit delta N-term Ge1_WD40 PF16529.5 CCF39106.1 - 0.011 14.7 0.8 1.1 8.1 0.0 3.4 2 2 1 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein IKI3 PF04762.12 CCF39106.1 - 0.77 7.7 3.1 3.4 5.5 0.0 2.2 2 0 0 2 2 2 0 IKI3 family fn3_5 PF06280.12 CCF39107.1 - 1e-18 68.1 0.0 2e-18 67.2 0.0 1.5 1 0 0 1 1 1 1 Fn3-like domain Peptidase_S8 PF00082.22 CCF39107.1 - 4.2e-09 36.1 0.0 8.7e-09 35.1 0.0 1.6 1 0 0 1 1 1 1 Subtilase family FlgD_ig PF13860.6 CCF39107.1 - 1.9e-06 27.6 0.1 6.2e-06 26.0 0.0 1.9 2 0 0 2 2 2 1 FlgD Ig-like domain EFG_IV PF03764.18 CCF39108.1 - 4.7e-24 84.5 0.0 1.9e-23 82.5 0.0 2.0 2 1 1 3 3 3 1 Elongation factor G, domain IV EFG_C PF00679.24 CCF39108.1 - 3.1e-19 68.8 0.0 5.3e-19 68.0 0.0 1.4 1 0 0 1 1 1 1 Elongation factor G C-terminus DNA_pol_phi PF04931.13 CCF39109.1 - 9.2e-161 536.6 21.0 1.5e-160 535.9 21.0 1.4 1 0 0 1 1 1 1 DNA polymerase phi DUF29 PF01724.16 CCF39109.1 - 0.003 17.8 1.1 2.8 8.2 0.1 2.7 2 0 0 2 2 2 2 Domain of unknown function DUF29 DUF3619 PF12279.8 CCF39109.1 - 0.031 14.6 2.7 0.15 12.4 0.8 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3619) L27_1 PF09058.10 CCF39109.1 - 0.062 13.3 2.4 3.6 7.6 0.2 3.4 2 1 0 2 2 2 0 L27_1 DUF1676 PF07898.13 CCF39109.1 - 0.22 11.5 3.9 0.75 9.8 3.9 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1676) SDA1 PF05285.12 CCF39109.1 - 0.63 9.4 40.6 0.013 15.0 32.5 2.3 2 1 0 2 2 2 0 SDA1 Mg_trans_NIPA PF05653.14 CCF39114.1 - 1e-90 303.9 25.5 1.3e-90 303.5 25.5 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 CCF39114.1 - 5.5e-06 26.6 7.8 5.5e-06 26.6 7.8 3.2 3 0 0 3 3 3 1 EamA-like transporter family SLC35F PF06027.12 CCF39114.1 - 3.2 7.2 17.3 15 5.0 16.6 2.1 1 1 1 2 2 2 0 Solute carrier family 35 DUF5373 PF17343.2 CCF39114.1 - 6 6.7 14.7 2.3 8.0 1.8 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5373) DUF805 PF05656.14 CCF39114.1 - 8.2 6.9 12.6 11 6.5 4.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF805) Pkinase PF00069.25 CCF39117.1 - 3.6e-30 105.2 0.0 1.5e-29 103.2 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF39117.1 - 2.6e-11 43.3 0.1 5.6e-10 38.9 0.0 2.5 2 1 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CCF39117.1 - 0.0011 17.8 0.0 0.0016 17.3 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase RIO1 PF01163.22 CCF39117.1 - 0.2 11.2 0.0 0.33 10.5 0.0 1.3 1 0 0 1 1 1 0 RIO1 family DUF3592 PF12158.8 CCF39118.1 - 0.034 14.2 0.1 0.034 14.2 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3592) Gram_pos_anchor PF00746.21 CCF39119.1 - 2.2 8.3 4.6 3.7 7.6 4.6 1.3 1 0 0 1 1 1 0 LPXTG cell wall anchor motif Mgm101p PF06420.12 CCF39120.1 - 1.8e-86 287.9 0.0 2.3e-86 287.6 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial genome maintenance MGM101 Ndc1_Nup PF09531.10 CCF39120.1 - 0.072 11.8 2.9 0.091 11.4 2.9 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup TB2_DP1_HVA22 PF03134.19 CCF39121.1 - 5.4e-27 93.5 8.7 8.4e-27 92.9 8.7 1.3 1 0 0 1 1 1 1 TB2/DP1, HVA22 family AA_permease_2 PF13520.6 CCF39122.1 - 3.4e-63 213.9 50.0 4.2e-63 213.6 50.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CCF39122.1 - 1.4e-28 99.8 37.0 1.8e-28 99.4 37.0 1.1 1 0 0 1 1 1 1 Amino acid permease GMC_oxred_N PF00732.19 CCF39123.1 - 1.5e-56 192.0 0.1 2.4e-56 191.3 0.1 1.3 1 1 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCF39123.1 - 3e-31 108.9 0.4 5.1e-31 108.1 0.4 1.4 1 0 0 1 1 1 1 GMC oxidoreductase Pyr_redox_2 PF07992.14 CCF39123.1 - 6.1e-05 22.4 0.2 0.015 14.5 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCF39123.1 - 0.00026 21.1 0.0 0.00089 19.4 0.0 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 CCF39123.1 - 0.00091 18.4 0.2 0.024 13.7 0.0 2.3 2 1 0 2 2 2 1 FAD binding domain DAO PF01266.24 CCF39123.1 - 0.00099 18.8 0.2 0.0059 16.2 0.0 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 CCF39123.1 - 0.0012 18.2 0.0 0.002 17.4 0.0 1.2 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.6 CCF39123.1 - 0.0031 16.8 0.0 0.26 10.5 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CCF39123.1 - 0.015 14.0 0.0 0.091 11.4 0.0 1.9 2 0 0 2 2 2 0 HI0933-like protein Lycopene_cycl PF05834.12 CCF39123.1 - 0.053 12.6 0.0 0.085 11.9 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein NAD_binding_9 PF13454.6 CCF39123.1 - 0.08 12.9 0.1 0.22 11.5 0.0 1.7 2 0 0 2 2 2 0 FAD-NAD(P)-binding TrkA_N PF02254.18 CCF39123.1 - 0.083 13.2 0.1 0.15 12.3 0.1 1.4 1 0 0 1 1 1 0 TrkA-N domain Pyr_redox PF00070.27 CCF39123.1 - 0.16 12.5 0.1 0.32 11.6 0.1 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase COesterase PF00135.28 CCF39124.1 - 5.9e-89 299.3 0.0 7.3e-89 299.0 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CCF39124.1 - 0.0011 18.9 0.1 0.0023 17.8 0.0 1.5 2 0 0 2 2 2 1 alpha/beta hydrolase fold TraL PF07178.11 CCF39125.1 - 0.024 15.1 3.7 0.63 10.6 0.3 2.2 2 0 0 2 2 2 0 TraL protein DUF4120 PF13496.6 CCF39126.1 - 0.022 15.1 0.2 0.091 13.1 0.1 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4120) DUF1415 PF07209.12 CCF39126.1 - 0.072 12.8 0.0 0.83 9.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1415) PQ-loop PF04193.14 CCF39127.1 - 1.8e-20 72.4 17.3 9.7e-12 44.5 0.8 3.3 3 1 1 4 4 4 2 PQ loop repeat R3H PF01424.22 CCF39128.1 - 0.00047 20.1 0.0 0.00071 19.5 0.0 1.3 1 0 0 1 1 1 1 R3H domain TraT PF05818.12 CCF39128.1 - 0.18 11.5 0.0 0.19 11.4 0.0 1.1 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein Amidase PF01425.21 CCF39129.1 - 1.5e-69 235.1 0.0 4.2e-68 230.3 0.0 2.0 1 1 0 1 1 1 1 Amidase NAD_binding_4 PF07993.12 CCF39131.1 - 2.8e-32 111.9 0.0 4.2e-32 111.3 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein Peptidase_M36 PF02128.15 CCF39132.1 - 5.4e-55 187.1 0.0 6e-55 186.9 0.0 1.0 1 0 0 1 1 1 1 Fungalysin metallopeptidase (M36) DUF3602 PF12223.8 CCF39135.1 - 1.1e-25 90.0 14.0 1.1e-23 83.6 4.8 1.9 1 1 1 2 2 2 2 Protein of unknown function (DUF3602) Ank_2 PF12796.7 CCF39136.1 - 2.2e-59 198.0 0.0 1.2e-14 54.7 0.0 5.5 3 1 3 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CCF39136.1 - 2.7e-56 187.2 4.8 2.3e-08 34.4 0.1 9.5 4 2 6 10 10 10 10 Ankyrin repeats (many copies) Ank_5 PF13857.6 CCF39136.1 - 2.6e-50 167.8 5.5 1e-09 38.5 0.0 9.0 5 2 4 9 9 9 8 Ankyrin repeats (many copies) Ank PF00023.30 CCF39136.1 - 1.4e-44 148.6 8.9 5e-06 26.7 0.1 12.1 12 0 0 12 12 12 8 Ankyrin repeat Ank_3 PF13606.6 CCF39136.1 - 2.4e-42 138.0 8.1 8.3e-07 28.8 0.1 12.1 12 1 0 12 12 12 8 Ankyrin repeat MOZART1 PF12554.8 CCF39136.1 - 0.063 13.1 0.0 11 5.8 0.0 3.8 4 0 0 4 4 4 0 Mitotic-spindle organizing gamma-tubulin ring associated Pectate_lyase_3 PF12708.7 CCF39137.1 - 6e-89 297.5 9.3 2.5e-79 266.1 0.9 2.9 3 0 0 3 3 3 2 Pectate lyase superfamily protein End_N_terminal PF12218.8 CCF39137.1 - 1.5e-07 31.0 1.6 0.0022 17.6 0.1 2.7 2 0 0 2 2 2 2 N terminal extension of bacteriophage endosialidase Beta_helix PF13229.6 CCF39137.1 - 0.0018 18.1 1.0 0.0073 16.2 1.0 2.0 1 1 0 1 1 1 1 Right handed beta helix region Forkhead PF00250.18 CCF39138.1 - 3.3e-35 120.2 0.1 6.2e-35 119.3 0.1 1.5 1 0 0 1 1 1 1 Forkhead domain NAS PF03059.16 CCF39139.1 - 3.5e-40 138.1 0.0 5.6e-40 137.4 0.0 1.2 1 0 0 1 1 1 1 Nicotianamine synthase protein Methyltransf_31 PF13847.6 CCF39139.1 - 2.4e-08 33.9 0.0 5.3e-08 32.8 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF39139.1 - 0.0027 18.4 0.0 0.0067 17.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain AlaDh_PNT_C PF01262.21 CCF39139.1 - 0.041 13.2 0.0 0.061 12.6 0.0 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Methyltransf_11 PF08241.12 CCF39139.1 - 0.056 14.1 0.0 0.12 13.0 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Fungal_trans PF04082.18 CCF39140.1 - 3e-16 59.3 0.0 6.2e-16 58.2 0.0 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain SAVED PF18145.1 CCF39140.1 - 0.064 13.0 0.2 0.17 11.6 0.1 1.6 2 0 0 2 2 2 0 SMODS-associated and fused to various effectors sensor domain CoA_transf_3 PF02515.17 CCF39141.1 - 2.6e-44 151.9 0.1 3.5e-41 141.6 0.0 2.4 2 1 0 2 2 2 2 CoA-transferase family III p450 PF00067.22 CCF39142.1 - 3.6e-11 42.5 0.0 3.6e-11 42.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF2264 PF10022.9 CCF39143.1 - 2.5e-114 382.1 0.0 2.8e-114 381.9 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2264) MFS_1 PF07690.16 CCF39144.1 - 8.8e-23 80.8 24.0 8.8e-23 80.8 24.0 1.9 1 1 0 2 2 2 1 Major Facilitator Superfamily YajC PF02699.15 CCF39144.1 - 0.051 13.5 1.6 0.065 13.1 0.0 1.9 2 0 0 2 2 2 0 Preprotein translocase subunit DUF2070 PF09843.9 CCF39144.1 - 2.7 6.2 7.0 4.3 5.5 7.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) PI3_PI4_kinase PF00454.27 CCF39145.1 - 1.9e-44 152.3 0.0 3e-44 151.7 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase RXT2_N PF08595.11 CCF39146.1 - 0.1 12.7 3.5 0.13 12.3 3.5 1.4 1 1 0 1 1 1 0 RXT2-like, N-terminal NOA36 PF06524.12 CCF39146.1 - 0.12 11.7 7.1 0.14 11.5 7.1 1.1 1 0 0 1 1 1 0 NOA36 protein Astro_capsid_p PF12226.8 CCF39146.1 - 2.1 7.4 5.4 2.5 7.2 5.4 1.1 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Spc7_N PF15402.6 CCF39146.1 - 6.5 4.9 10.6 7.5 4.7 10.6 1.0 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 Ndc1_Nup PF09531.10 CCF39148.1 - 4.6e-143 478.1 0.0 5.2e-143 478.0 0.0 1.0 1 0 0 1 1 1 1 Nucleoporin protein Ndc1-Nup Hexose_dehydrat PF03559.14 CCF39148.1 - 0.017 14.5 0.1 0.027 13.9 0.1 1.3 1 0 0 1 1 1 0 NDP-hexose 2,3-dehydratase Chondroitinas_B PF14592.6 CCF39148.1 - 0.15 11.0 0.0 0.22 10.4 0.0 1.1 1 0 0 1 1 1 0 Chondroitinase B NICE-3 PF07406.11 CCF39149.1 - 0.0066 16.5 0.1 0.61 10.1 0.0 2.4 2 0 0 2 2 2 2 NICE-3 protein DUF4129 PF13559.6 CCF39149.1 - 0.016 15.5 0.0 0.05 13.9 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4129) DUF3537 PF12056.8 CCF39149.1 - 1.9 7.2 3.8 2.9 6.6 3.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3537) Zn_clus PF00172.18 CCF39151.1 - 1.9e-06 27.9 7.2 3.2e-06 27.1 7.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CCF39151.1 - 2.1e-05 23.7 0.1 2.1e-05 23.7 0.1 2.2 3 0 0 3 3 3 1 Fungal specific transcription factor domain RHD_DNA_bind PF00554.22 CCF39151.1 - 0.1 12.5 0.4 0.21 11.5 0.4 1.4 1 0 0 1 1 1 0 Rel homology DNA-binding domain DUF4503 PF14951.6 CCF39151.1 - 0.65 8.4 4.6 1 7.7 4.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4503) Asn_synthase PF00733.21 CCF39152.1 - 1.7e-66 225.3 0.0 2.4e-66 224.8 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.6 CCF39152.1 - 1.1e-34 119.0 0.0 1.7e-34 118.4 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 CCF39152.1 - 3e-33 114.9 0.0 5.3e-33 114.1 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.8 CCF39152.1 - 1.9e-06 27.5 0.0 3.4e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 Aluminium induced protein NAD_synthase PF02540.17 CCF39152.1 - 0.06 12.5 0.0 0.096 11.8 0.0 1.2 1 0 0 1 1 1 0 NAD synthase 3Beta_HSD PF01073.19 CCF39153.1 - 1.1e-26 93.5 0.0 8e-26 90.7 0.0 2.0 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 CCF39153.1 - 2.6e-08 33.6 0.0 4.6e-08 32.8 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 CCF39153.1 - 1.5e-07 30.9 0.1 4.1e-07 29.4 0.0 1.7 2 0 0 2 2 2 1 Male sterility protein NAD_binding_10 PF13460.6 CCF39153.1 - 3.4e-05 23.8 0.0 0.00019 21.4 0.0 2.1 1 1 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 CCF39153.1 - 0.00033 20.6 0.2 0.00075 19.5 0.2 1.5 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 CCF39153.1 - 0.00055 19.2 0.0 0.0008 18.6 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 CCF39153.1 - 0.043 12.9 0.0 0.1 11.7 0.0 1.6 2 0 0 2 2 2 0 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 CCF39153.1 - 0.086 12.2 0.0 0.13 11.7 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Sacchrp_dh_NADP PF03435.18 CCF39153.1 - 0.095 13.0 0.0 0.2 11.9 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain PS-DH PF14765.6 CCF39154.1 - 9.2e-64 215.5 0.0 1.3e-63 215.0 0.0 1.2 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 CCF39154.1 - 7.4e-53 180.1 0.0 1.1e-52 179.5 0.0 1.2 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 CCF39154.1 - 5.3e-24 84.5 0.0 1.2e-23 83.4 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 CCF39154.1 - 5.7e-24 84.7 0.0 1.3e-23 83.6 0.0 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Methyltransf_12 PF08242.12 CCF39154.1 - 1.8e-20 73.5 0.0 1.2e-19 70.9 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF39154.1 - 1.4e-12 48.1 0.0 4.1e-12 46.6 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF39154.1 - 1.8e-11 44.1 0.0 7.4e-11 42.1 0.0 2.0 3 0 0 3 3 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF39154.1 - 5.8e-11 42.9 0.0 2e-10 41.2 0.0 2.0 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF39154.1 - 1.2e-09 38.2 0.0 2.9e-09 37.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCF39154.1 - 0.00078 18.8 0.0 0.0015 18.0 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_16 PF10294.9 CCF39154.1 - 0.035 13.9 0.0 0.1 12.3 0.0 1.7 1 1 0 1 1 1 0 Lysine methyltransferase Thioesterase PF00975.20 CCF39154.1 - 0.07 13.2 0.0 0.2 11.8 0.0 1.7 1 0 0 1 1 1 0 Thioesterase domain RrnaAD PF00398.20 CCF39154.1 - 0.11 11.6 0.0 0.18 10.8 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase NUDIX PF00293.28 CCF39155.1 - 1.1e-06 28.8 2.7 3.2e-06 27.2 2.7 1.9 1 1 0 1 1 1 1 NUDIX domain ER_lumen_recept PF00810.18 CCF39156.1 - 4.3e-40 137.9 7.6 4.3e-40 137.9 7.6 1.8 3 0 0 3 3 3 1 ER lumen protein retaining receptor DUF4234 PF14018.6 CCF39156.1 - 1.6 8.9 14.0 0.2 11.8 1.0 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4234) ADK PF00406.22 CCF39158.1 - 1.2e-36 126.1 0.0 1.9e-20 73.5 0.0 2.1 2 0 0 2 2 2 2 Adenylate kinase ADK_lid PF05191.14 CCF39158.1 - 5.2e-15 55.1 0.0 1.2e-14 54.0 0.0 1.6 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_17 PF13207.6 CCF39158.1 - 2.6e-14 53.8 0.0 9.8e-11 42.2 0.0 2.2 1 1 0 2 2 2 2 AAA domain AAA_18 PF13238.6 CCF39158.1 - 5.7e-05 23.7 0.0 0.0005 20.6 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 CCF39158.1 - 0.016 15.4 0.0 0.04 14.1 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 CCF39158.1 - 0.035 14.1 0.0 0.076 13.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Guanylate_kin PF00625.21 CCF39158.1 - 0.17 11.6 0.0 0.37 10.5 0.0 1.5 2 0 0 2 2 2 0 Guanylate kinase AAA_22 PF13401.6 CCF39158.1 - 0.19 12.0 0.0 0.32 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain LETM1 PF07766.13 CCF39159.1 - 3.7e-106 354.4 1.3 3.7e-106 354.4 1.3 1.5 2 0 0 2 2 2 1 LETM1-like protein SAP PF02037.27 CCF39159.1 - 0.0013 18.4 0.1 0.057 13.2 0.0 3.1 3 0 0 3 3 3 1 SAP domain RAP1 PF07218.11 CCF39159.1 - 0.41 8.9 6.2 0.65 8.2 6.2 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF1180 PF06679.12 CCF39159.1 - 5.7 7.3 12.6 0.21 12.0 5.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) RTA1 PF04479.13 CCF39160.1 - 4.6e-48 163.6 14.2 1.3e-26 93.5 3.3 2.3 2 1 1 3 3 3 2 RTA1 like protein DUF2157 PF09925.9 CCF39160.1 - 0.15 11.8 6.6 1.1 9.0 6.6 2.3 1 1 0 1 1 1 0 Predicted membrane protein (DUF2157) DUF4131 PF13567.6 CCF39160.1 - 3.4 7.3 9.9 0.96 9.1 3.0 2.4 1 1 0 2 2 2 0 Domain of unknown function (DUF4131) Cupin_3 PF05899.12 CCF39161.1 - 1.5e-06 27.8 0.0 2.4e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF861) EutQ PF06249.12 CCF39161.1 - 0.0012 18.6 0.0 0.0013 18.5 0.0 1.1 1 0 0 1 1 1 1 Ethanolamine utilisation protein EutQ Pirin PF02678.16 CCF39161.1 - 0.13 12.3 0.0 0.16 12.0 0.0 1.2 1 0 0 1 1 1 0 Pirin MFS_1 PF07690.16 CCF39163.1 - 5.6e-34 117.6 52.1 8.3e-33 113.8 52.0 2.9 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF39163.1 - 1e-09 37.8 32.7 5.2e-08 32.2 14.2 2.8 3 1 0 3 3 3 2 Sugar (and other) transporter adh_short PF00106.25 CCF39164.1 - 1.2e-27 96.7 0.2 1.3e-24 86.7 0.1 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCF39164.1 - 1.6e-15 57.3 0.0 9.5e-15 54.8 0.0 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF39164.1 - 3.1e-07 30.5 0.3 6.3e-07 29.5 0.3 1.5 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF39164.1 - 8.8e-07 28.6 0.1 1.2e-06 28.2 0.1 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 CCF39164.1 - 0.036 13.6 0.2 0.064 12.8 0.2 1.4 1 0 0 1 1 1 0 NmrA-like family GDP_Man_Dehyd PF16363.5 CCF39164.1 - 0.16 11.3 0.4 0.4 10.0 0.3 1.8 1 1 1 2 2 2 0 GDP-mannose 4,6 dehydratase adh_short PF00106.25 CCF39166.1 - 1.7e-31 109.2 0.1 3.1e-23 82.3 0.1 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCF39166.1 - 1.2e-21 77.4 0.1 1.5e-16 60.7 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF39166.1 - 2.8e-10 40.4 0.0 4.4e-10 39.7 0.0 1.3 1 0 0 1 1 1 1 KR domain EthD PF07110.11 CCF39167.1 - 2.6e-10 41.3 0.1 3.1e-10 41.1 0.1 1.1 1 0 0 1 1 1 1 EthD domain Polyketide_cyc2 PF10604.9 CCF39168.1 - 0.013 15.8 0.0 0.022 15.0 0.0 1.4 1 0 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport MFS_1 PF07690.16 CCF39169.1 - 1.1e-41 142.9 31.2 1.1e-41 142.9 31.2 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF39169.1 - 1.3e-14 54.0 11.8 3e-14 52.7 11.8 1.7 1 1 0 1 1 1 1 Sugar (and other) transporter DUF1129 PF06570.11 CCF39169.1 - 0.6 9.6 7.1 0.14 11.6 0.2 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1129) DUF3817 PF12823.7 CCF39169.1 - 3.4 8.5 8.4 0.64 10.9 0.5 3.6 3 2 1 4 4 4 0 Domain of unknown function (DUF3817) Fasciclin PF02469.22 CCF39170.1 - 1e-28 100.1 0.0 7.3e-18 65.0 0.0 2.3 2 0 0 2 2 2 2 Fasciclin domain RINGv PF12906.7 CCF39172.1 - 0.0001 22.4 7.7 0.00017 21.6 7.7 1.4 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.6 CCF39172.1 - 0.00096 19.4 6.4 0.0015 18.8 6.4 1.3 1 0 0 1 1 1 1 Ring finger domain FANCL_C PF11793.8 CCF39172.1 - 0.0013 18.8 3.9 0.0024 18.0 3.9 1.4 1 0 0 1 1 1 1 FANCL C-terminal domain NBD_C PF17042.5 CCF39172.1 - 0.086 13.4 0.9 0.14 12.7 0.9 1.3 1 0 0 1 1 1 0 Nucleotide-binding C-terminal domain zf-RING_4 PF14570.6 CCF39172.1 - 0.53 10.1 4.8 1.1 9.1 4.8 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.7 CCF39172.1 - 3 8.2 5.7 5.8 7.3 5.7 1.4 1 0 0 1 1 1 0 RING-H2 zinc finger domain Abhydrolase_2 PF02230.16 CCF39173.1 - 7.7e-23 81.4 0.0 5.5e-16 59.0 0.1 2.1 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 CCF39173.1 - 0.064 12.7 0.1 0.23 10.9 0.1 1.9 1 1 0 1 1 1 0 Prolyl oligopeptidase family OrsD PF12013.8 CCF39174.1 - 5.9e-13 49.3 0.1 1e-12 48.5 0.1 1.4 1 0 0 1 1 1 1 Orsellinic acid/F9775 biosynthesis cluster protein D RNA_POL_M_15KD PF02150.16 CCF39174.1 - 0.064 13.2 0.1 3 7.8 0.0 2.6 2 0 0 2 2 2 0 RNA polymerases M/15 Kd subunit zf-H2C2_5 PF13909.6 CCF39174.1 - 1.1 9.0 9.3 0.41 10.5 3.8 2.4 2 0 0 2 2 2 0 C2H2-type zinc-finger domain Abhydrolase_1 PF00561.20 CCF39175.1 - 2.4e-23 83.1 0.2 7.2e-21 75.0 0.2 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_4 PF08386.10 CCF39175.1 - 1.3e-20 73.4 0.0 2.8e-20 72.4 0.0 1.6 1 0 0 1 1 1 1 TAP-like protein p450 PF00067.22 CCF39176.1 - 3.1e-39 135.0 0.0 4e-39 134.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 ApbA_C PF08546.11 CCF39176.1 - 0.12 12.5 0.0 0.27 11.4 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA C terminal Cerato-platanin PF07249.12 CCF39177.1 - 6.3e-57 190.8 2.8 7.3e-57 190.6 2.8 1.0 1 0 0 1 1 1 1 Cerato-platanin CKS PF01111.19 CCF39179.1 - 9.5e-33 112.3 1.5 1.5e-32 111.6 1.5 1.3 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit Bromodomain PF00439.25 CCF39180.1 - 6.6e-33 112.6 0.1 1.9e-15 56.7 0.0 2.4 2 0 0 2 2 2 2 Bromodomain Nop14 PF04147.12 CCF39180.1 - 0.0035 15.6 6.4 0.0035 15.6 6.4 1.6 2 0 0 2 2 2 1 Nop14-like family SDA1 PF05285.12 CCF39180.1 - 0.037 13.5 9.4 0.076 12.4 9.4 1.4 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 CCF39180.1 - 0.21 9.8 5.8 0.3 9.3 5.8 1.2 1 0 0 1 1 1 0 CDC45-like protein PPP4R2 PF09184.11 CCF39180.1 - 0.78 9.3 12.7 1.7 8.2 12.7 1.5 1 0 0 1 1 1 0 PPP4R2 DUF4746 PF15928.5 CCF39180.1 - 0.89 8.9 7.0 2.2 7.6 7.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Cwf_Cwc_15 PF04889.12 CCF39180.1 - 2.2 8.0 15.4 0.12 12.1 9.9 1.7 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Pox_Ag35 PF03286.14 CCF39180.1 - 4.9 6.9 9.0 14 5.4 9.0 1.8 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Peptidase_M24 PF00557.24 CCF39181.1 - 2.5e-08 33.9 0.0 3.2e-08 33.5 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 Chorismate_synt PF01264.21 CCF39182.1 - 1e-137 458.2 0.0 1.2e-137 458.1 0.0 1.0 1 0 0 1 1 1 1 Chorismate synthase BPL_LplA_LipB PF03099.19 CCF39183.1 - 3e-06 27.2 0.0 5.7e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family DUF5402 PF17393.2 CCF39183.1 - 0.18 11.7 0.0 0.38 10.7 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5402) TMEM208_SND2 PF05620.11 CCF39184.1 - 7.2e-52 175.6 0.1 7.9e-52 175.4 0.1 1.0 1 0 0 1 1 1 1 SRP-independent targeting protein 2/TMEM208 DUF3605 PF12239.8 CCF39185.1 - 5.8e-58 195.6 0.0 7e-58 195.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3605) EBP PF05241.12 CCF39186.1 - 2.8e-59 199.6 14.0 3.3e-59 199.3 14.0 1.0 1 0 0 1 1 1 1 Emopamil binding protein GAS2 PF02187.17 CCF39187.1 - 3.3e-06 27.1 0.0 7.2e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain Fungal_trans_2 PF11951.8 CCF39188.1 - 1.1e-20 73.9 0.5 1.5e-20 73.4 0.5 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF39188.1 - 8.7e-08 32.2 5.2 1.2e-07 31.7 5.2 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Methyltransf_2 PF00891.18 CCF39189.1 - 1.2e-18 67.2 0.0 1.8e-18 66.6 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain Thg1 PF04446.12 CCF39189.1 - 0.064 13.3 0.1 0.11 12.5 0.1 1.3 1 0 0 1 1 1 0 tRNAHis guanylyltransferase Rrf2 PF02082.20 CCF39189.1 - 0.068 13.5 0.0 0.15 12.5 0.0 1.5 1 0 0 1 1 1 0 Transcriptional regulator DEC-1_N PF04625.13 CCF39191.1 - 0.044 12.8 9.3 0.055 12.5 9.3 1.1 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region Peptidase_S10 PF00450.22 CCF39192.1 - 1.1e-44 153.5 0.0 1.5e-44 153.1 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Aha1_N PF09229.11 CCF39193.1 - 4.2e-43 146.9 0.9 5.1e-43 146.6 0.9 1.1 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal OMS28_porin PF03532.13 CCF39193.1 - 0.053 12.8 0.2 0.074 12.3 0.2 1.2 1 0 0 1 1 1 0 OMS28 porin TNV_CP PF03898.13 CCF39193.1 - 0.055 12.7 0.1 0.097 11.9 0.1 1.3 1 0 0 1 1 1 0 Satellite tobacco necrosis virus coat protein ATG7_N PF16420.5 CCF39194.1 - 4.7e-111 371.2 0.0 6.5e-111 370.7 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-like modifier-activating enzyme ATG7 N-terminus ThiF PF00899.21 CCF39194.1 - 6.3e-45 153.4 0.0 8.9e-45 152.9 0.0 1.1 1 0 0 1 1 1 1 ThiF family Shikimate_DH PF01488.20 CCF39194.1 - 0.11 12.5 0.0 0.54 10.3 0.0 1.9 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Glycophorin_A PF01102.18 CCF39195.1 - 0.00061 20.0 0.4 0.0015 18.7 0.4 1.6 1 0 0 1 1 1 1 Glycophorin A Kelch_3 PF13415.6 CCF39195.1 - 0.026 14.8 10.3 0.15 12.4 0.0 4.3 4 0 0 4 4 4 0 Galactose oxidase, central domain Amnionless PF14828.6 CCF39195.1 - 0.063 12.1 0.0 0.092 11.6 0.0 1.2 1 0 0 1 1 1 0 Amnionless CD34_antigen PF06365.12 CCF39195.1 - 0.1 12.2 0.0 0.2 11.2 0.0 1.4 1 0 0 1 1 1 0 CD34/Podocalyxin family Nitrate_red_gam PF02665.14 CCF39195.1 - 0.12 12.0 0.3 0.2 11.1 0.3 1.3 1 0 0 1 1 1 0 Nitrate reductase gamma subunit Herpes_gE PF02480.16 CCF39195.1 - 0.14 10.9 0.0 0.24 10.1 0.0 1.4 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E CD34_antigen PF06365.12 CCF39196.1 - 0.12 12.0 0.0 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 CD34/Podocalyxin family B12D PF06522.11 CCF39196.1 - 0.12 12.2 0.0 0.28 11.0 0.0 1.6 1 0 0 1 1 1 0 NADH-ubiquinone reductase complex 1 MLRQ subunit HAD PF12710.7 CCF39197.1 - 1.4e-19 71.3 0.1 1.9e-19 70.8 0.1 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CCF39197.1 - 1.4e-14 54.9 0.8 2.3e-14 54.2 0.8 1.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 CCF39197.1 - 2.9e-07 30.5 1.5 1.2e-06 28.4 0.1 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF705 PF05152.12 CCF39197.1 - 0.0097 15.4 0.0 0.016 14.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF705) HAD_2 PF13419.6 CCF39197.1 - 0.13 12.3 0.3 21 5.2 0.1 2.7 2 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.12 CCF39197.1 - 0.24 10.8 0.0 13 5.1 0.0 2.2 2 0 0 2 2 2 0 Putative Phosphatase Gpi16 PF04113.14 CCF39198.1 - 1.7e-245 815.7 0.0 2.2e-245 815.4 0.0 1.0 1 0 0 1 1 1 1 Gpi16 subunit, GPI transamidase component LUC7 PF03194.15 CCF39199.1 - 1.8e-70 237.5 1.2 2.2e-70 237.2 1.2 1.0 1 0 0 1 1 1 1 LUC7 N_terminus DUF1241 PF06840.11 CCF39199.1 - 0.13 11.9 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1241) Zn_clus PF00172.18 CCF39200.1 - 2.1e-08 34.1 10.7 3.4e-08 33.5 10.7 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 CCF39200.1 - 0.03 13.2 0.7 0.048 12.5 0.7 1.3 1 0 0 1 1 1 0 Fungal specific transcription factor domain zf-PARP PF00645.18 CCF39200.1 - 2.1 9.3 5.0 5.7 7.9 5.0 1.7 1 0 0 1 1 1 0 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region IF4E PF01652.18 CCF39201.1 - 1.8e-44 151.4 0.6 2.2e-44 151.1 0.6 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E MFS_1 PF07690.16 CCF39204.1 - 2.9e-12 46.2 33.8 2.9e-12 46.2 33.8 2.5 2 1 0 2 2 2 1 Major Facilitator Superfamily Myb_Cef PF11831.8 CCF39205.1 - 7.5e-51 173.0 8.7 7.5e-51 173.0 8.7 2.8 2 0 0 2 2 2 1 pre-mRNA splicing factor component Myb_DNA-binding PF00249.31 CCF39205.1 - 2.6e-23 81.9 5.3 8.5e-11 41.9 0.9 2.8 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CCF39205.1 - 7.3e-22 77.4 7.1 6.8e-15 55.1 2.9 3.3 2 1 1 3 3 3 2 Myb-like DNA-binding domain TAF1D PF15333.6 CCF39205.1 - 0.065 13.0 6.6 0.14 11.9 6.6 1.6 1 0 0 1 1 1 0 TATA box-binding protein-associated factor 1D Rap1_C PF11626.8 CCF39205.1 - 0.22 11.6 0.1 0.22 11.6 0.1 3.2 4 0 0 4 4 4 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain RAP1 PF07218.11 CCF39207.1 - 1.1 7.5 3.4 1.8 6.8 3.4 1.2 1 1 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF4149 PF13664.6 CCF39208.1 - 2.7e-20 72.6 3.2 3.6e-20 72.2 1.5 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4149) DUF1772 PF08592.11 CCF39208.1 - 0.00046 20.5 0.1 0.00065 20.0 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1772) Protocadherin PF08374.11 CCF39208.1 - 0.034 14.1 0.0 0.044 13.8 0.0 1.1 1 0 0 1 1 1 0 Protocadherin Ku_PK_bind PF08785.11 CCF39209.1 - 6.4e-32 110.2 0.0 1.7e-31 108.8 0.0 1.8 2 0 0 2 2 2 1 Ku C terminal domain like Ku PF02735.16 CCF39209.1 - 5e-30 104.7 0.0 7.9e-30 104.1 0.0 1.3 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.15 CCF39209.1 - 2.5e-12 47.0 0.0 8.6e-12 45.3 0.0 1.8 2 0 0 2 2 2 1 Ku70/Ku80 N-terminal alpha/beta domain VWA PF00092.28 CCF39209.1 - 0.00013 22.3 0.0 0.00025 21.4 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain IlvC PF01450.19 CCF39209.1 - 0.059 13.7 0.0 0.22 11.8 0.0 1.9 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, catalytic domain Pam16 PF03656.13 CCF39211.1 - 1.5e-06 28.3 0.0 1.7e-06 28.0 0.0 1.2 1 1 0 1 1 1 1 Pam16 DnaJ PF00226.31 CCF39211.1 - 3.3e-05 23.9 0.0 5e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain DUF3918 PF13056.6 CCF39211.1 - 0.021 14.4 1.1 0.021 14.4 1.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3918) Ribosomal_L24e PF01246.20 CCF39212.1 - 3.4e-31 107.3 6.0 6.4e-31 106.4 6.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L24e Tox-REase-2 PF15646.6 CCF39212.1 - 0.15 12.2 2.2 0.29 11.3 0.5 2.2 2 1 0 2 2 2 0 Restriction endonuclease fold toxin 2 ABC_tran_CTD PF16326.5 CCF39214.1 - 7.1e-05 23.0 4.6 7.1e-05 23.0 4.6 5.5 4 3 0 5 5 5 1 ABC transporter C-terminal domain EzrA PF06160.12 CCF39214.1 - 0.00031 19.1 18.4 0.00031 19.1 18.4 3.2 2 1 1 3 3 3 1 Septation ring formation regulator, EzrA Occludin_ELL PF07303.13 CCF39214.1 - 0.0089 16.7 3.7 0.0089 16.7 3.7 5.2 2 1 3 5 5 5 2 Occludin homology domain BAG PF02179.16 CCF39214.1 - 0.016 15.6 1.0 0.016 15.6 1.0 4.4 4 0 0 4 4 4 0 BAG domain CorA PF01544.18 CCF39214.1 - 1.4 8.2 9.4 3.5 6.9 9.4 1.7 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein DUF4041 PF13250.6 CCF39214.1 - 2.1 8.3 7.1 4 7.4 0.2 3.7 4 0 0 4 4 4 0 Domain of unknown function (DUF4041) DUF4239 PF14023.6 CCF39214.1 - 3.8 7.2 10.0 1.7 8.4 1.9 2.9 1 1 0 2 2 2 0 Protein of unknown function (DUF4239) DUF749 PF05370.11 CCF39214.1 - 8.5 6.5 11.1 1.3 9.2 0.3 3.9 3 1 1 4 4 4 0 Domain of unknown function (DUF749) Ku PF02735.16 CCF39216.1 - 2e-45 155.0 0.0 3e-45 154.4 0.0 1.2 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_C PF03730.14 CCF39216.1 - 1.3e-28 99.5 2.2 2.9e-28 98.4 2.2 1.6 1 0 0 1 1 1 1 Ku70/Ku80 C-terminal arm Ku_N PF03731.15 CCF39216.1 - 1.4e-12 47.8 0.1 2.1e-12 47.3 0.1 1.3 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain SAP PF02037.27 CCF39216.1 - 1.4e-10 40.6 0.1 6.4e-10 38.6 0.1 2.1 2 0 0 2 2 2 1 SAP domain Cas_Cmr5 PF09701.10 CCF39216.1 - 0.0073 16.6 0.0 0.016 15.5 0.0 1.6 1 0 0 1 1 1 1 CRISPR-associated protein (Cas_Cmr5) GMC_oxred_C PF05199.13 CCF39217.1 - 2.3e-19 70.3 0.0 2.7e-19 70.1 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase Peptidase_M41 PF01434.18 CCF39220.1 - 4.5e-57 193.0 1.3 7.6e-57 192.2 1.3 1.4 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 CCF39220.1 - 7e-43 146.2 0.0 1.6e-42 145.0 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CCF39220.1 - 3.1e-08 33.3 0.1 6.5e-08 32.3 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain TIP49 PF06068.13 CCF39220.1 - 5.3e-05 22.6 0.0 0.00012 21.4 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_5 PF07728.14 CCF39220.1 - 5.8e-05 23.1 0.0 0.00019 21.4 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CCF39220.1 - 0.00023 21.6 0.8 0.0039 17.6 0.3 3.0 2 1 0 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 CCF39220.1 - 0.0011 18.7 0.0 0.0024 17.7 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 CCF39220.1 - 0.0012 19.1 0.0 0.15 12.4 0.0 2.9 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 CCF39220.1 - 0.0023 18.1 0.0 0.0053 16.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 CCF39220.1 - 0.0095 15.3 0.4 0.021 14.2 0.4 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 CCF39220.1 - 0.018 14.7 0.0 0.042 13.6 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_2 PF07724.14 CCF39220.1 - 0.026 14.7 0.0 0.074 13.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_25 PF13481.6 CCF39220.1 - 0.062 12.9 0.6 2.8 7.5 0.2 2.4 1 1 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 CCF39220.1 - 0.091 12.0 1.3 0.3 10.4 0.5 2.1 1 1 1 2 2 2 0 Zeta toxin AAA_17 PF13207.6 CCF39220.1 - 0.14 12.6 0.0 0.35 11.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain ATG16 PF08614.11 CCF39221.1 - 0.011 16.0 19.9 0.011 16.0 19.9 11.9 3 3 9 12 12 12 0 Autophagy protein 16 (ATG16) Epimerase PF01370.21 CCF39222.1 - 6.6e-10 38.9 0.2 1.2e-09 38.0 0.2 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 CCF39222.1 - 1.8e-05 24.4 0.4 2.3e-05 24.1 0.4 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CCF39222.1 - 5.4e-05 23.2 0.0 5.6e-05 23.1 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding adh_short PF00106.25 CCF39222.1 - 0.00082 18.9 0.5 0.0013 18.2 0.5 1.4 1 1 0 1 1 1 1 short chain dehydrogenase GDP_Man_Dehyd PF16363.5 CCF39222.1 - 0.008 15.6 0.1 0.0094 15.4 0.1 1.4 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 CCF39222.1 - 0.051 12.7 0.0 0.19 10.8 0.0 1.9 2 0 0 2 2 2 0 RmlD substrate binding domain Methyltransf_23 PF13489.6 CCF39224.1 - 8.1e-14 51.8 0.0 1.6e-13 50.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF39224.1 - 3.1e-11 43.8 0.0 1e-10 42.2 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF39224.1 - 8.1e-09 36.1 0.0 2.6e-08 34.5 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF39224.1 - 1.2e-08 34.9 0.0 1.1e-07 31.8 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF39224.1 - 4.4e-08 33.7 0.0 1.4e-07 32.0 0.0 1.9 2 0 0 2 2 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCF39224.1 - 3.2e-06 26.6 0.0 1.7e-05 24.3 0.0 2.0 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 CCF39224.1 - 0.00048 19.6 0.0 0.0012 18.3 0.0 1.6 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_2 PF00891.18 CCF39224.1 - 0.0037 16.6 0.0 0.011 15.0 0.0 1.8 1 1 0 1 1 1 1 O-methyltransferase domain MTS PF05175.14 CCF39224.1 - 0.0058 16.2 0.0 0.012 15.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain CMAS PF02353.20 CCF39224.1 - 0.1 11.9 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase RXT2_N PF08595.11 CCF39224.1 - 4.4 7.3 8.1 4.5 7.3 4.3 2.4 2 0 0 2 2 2 0 RXT2-like, N-terminal Aa_trans PF01490.18 CCF39226.1 - 6.6e-49 166.7 41.9 7.6e-49 166.5 41.9 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein COX2_TM PF02790.15 CCF39226.1 - 0.023 14.8 3.2 0.023 14.8 3.2 2.8 3 0 0 3 3 3 0 Cytochrome C oxidase subunit II, transmembrane domain Lactonase PF10282.9 CCF39227.1 - 4e-58 197.3 0.2 1e-57 195.9 0.2 1.5 1 1 0 1 1 1 1 Lactonase, 7-bladed beta-propeller SBP56 PF05694.11 CCF39227.1 - 0.00036 19.5 0.0 0.64 8.8 0.0 2.2 2 0 0 2 2 2 2 56kDa selenium binding protein (SBP56) DUF5437 PF17505.2 CCF39227.1 - 0.0099 15.9 0.1 0.022 14.8 0.1 1.6 1 0 0 1 1 1 1 Family of unknown function (DUF5437) Cytochrom_D1 PF02239.16 CCF39227.1 - 0.06 11.9 0.1 4.7 5.6 0.0 2.1 1 1 1 2 2 2 0 Cytochrome D1 heme domain YmzC PF14157.6 CCF39227.1 - 0.18 11.9 0.0 0.39 10.8 0.0 1.5 1 0 0 1 1 1 0 YmzC-like protein NAD_binding_10 PF13460.6 CCF39228.1 - 1.3e-08 34.9 0.0 1.6e-08 34.6 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding MFS_1 PF07690.16 CCF39229.1 - 1.9e-39 135.6 43.6 3.2e-25 88.8 18.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 CCF39229.1 - 0.032 13.1 17.9 0.13 11.1 1.9 2.8 1 1 0 2 2 2 0 MFS_1 like family SVM_signal PF12113.8 CCF39229.1 - 1.5 8.8 5.4 0.23 11.4 0.7 2.0 2 0 0 2 2 2 0 SVM protein signal sequence Sulfate_transp PF00916.20 CCF39231.1 - 2.2e-88 296.6 21.6 2.8e-88 296.2 21.6 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 CCF39231.1 - 4.9e-11 42.3 0.0 9.3e-11 41.4 0.0 1.4 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.6 CCF39231.1 - 0.048 14.0 0.0 0.12 12.7 0.0 1.7 1 0 0 1 1 1 0 STAS domain Lactamase_B PF00753.27 CCF39232.1 - 7.4e-18 65.3 2.8 1.1e-17 64.7 2.8 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CCF39232.1 - 0.0023 17.5 0.3 0.0043 16.6 0.3 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain CFEM PF05730.11 CCF39233.1 - 1.2e-10 41.3 8.7 1.9e-10 40.7 8.7 1.3 1 0 0 1 1 1 1 CFEM domain Glyco_transf_90 PF05686.12 CCF39236.1 - 9e-06 24.8 0.9 0.023 13.6 0.0 3.4 3 1 0 3 3 3 2 Glycosyl transferase family 90 Terpene_synth_C PF03936.16 CCF39237.1 - 0.0033 16.8 0.0 0.0041 16.5 0.0 1.2 1 0 0 1 1 1 1 Terpene synthase family, metal binding domain Mac PF12464.8 CCF39237.1 - 0.12 12.6 0.3 1.8 8.9 0.2 2.5 2 0 0 2 2 2 0 Maltose acetyltransferase Redoxin PF08534.10 CCF39238.1 - 1.6e-25 89.5 0.0 1.9e-25 89.3 0.0 1.1 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 CCF39238.1 - 9.2e-08 32.0 0.0 1.2e-07 31.7 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family His_Phos_2 PF00328.22 CCF39239.1 - 1.3e-75 255.1 0.2 1.9e-75 254.6 0.2 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) PPIP5K2_N PF18086.1 CCF39239.1 - 2.5e-36 123.7 0.1 4.7e-36 122.8 0.1 1.4 1 0 0 1 1 1 1 Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain RimK PF08443.11 CCF39239.1 - 4.6e-06 26.4 0.0 8.1e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 RimK-like ATP-grasp domain Fungal_trans PF04082.18 CCF39240.1 - 7.2e-10 38.3 0.0 1.3e-09 37.5 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF39240.1 - 1.3e-06 28.4 9.5 1.3e-06 28.4 9.5 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ABC_tran PF00005.27 CCF39241.1 - 5.1e-31 108.0 0.0 1.1e-17 64.9 0.1 2.8 2 1 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 CCF39241.1 - 1.4e-12 48.1 0.1 8.9e-05 22.4 0.0 3.3 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC2_membrane_3 PF12698.7 CCF39241.1 - 7.3e-09 35.2 17.5 1e-08 34.7 17.5 1.2 1 0 0 1 1 1 1 ABC-2 family transporter protein SMC_N PF02463.19 CCF39241.1 - 1e-06 28.4 0.1 0.15 11.5 0.1 3.2 3 0 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CCF39241.1 - 0.00098 19.7 0.2 0.0017 18.9 0.2 1.3 1 0 0 1 1 1 1 AAA domain ABC2_membrane PF01061.24 CCF39241.1 - 0.0014 18.1 12.2 0.0014 18.1 12.2 1.9 3 0 0 3 3 3 1 ABC-2 type transporter RsgA_GTPase PF03193.16 CCF39241.1 - 0.0022 17.9 0.0 0.0037 17.2 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 CCF39241.1 - 0.003 17.3 0.1 0.0065 16.2 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain IstB_IS21 PF01695.17 CCF39241.1 - 0.0078 16.0 0.0 5.5 6.7 0.0 3.1 3 0 0 3 3 3 1 IstB-like ATP binding protein AAA_16 PF13191.6 CCF39241.1 - 0.018 15.4 0.0 0.032 14.6 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain SbcCD_C PF13558.6 CCF39241.1 - 0.034 14.4 0.0 17 5.8 0.0 3.2 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit MMR_HSR1 PF01926.23 CCF39241.1 - 0.11 12.6 0.1 0.24 11.5 0.1 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_15 PF13175.6 CCF39241.1 - 0.14 11.8 0.3 0.22 11.2 0.3 1.2 1 0 0 1 1 1 0 AAA ATPase domain AAA_14 PF13173.6 CCF39241.1 - 0.17 11.9 0.0 0.49 10.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 CCF39241.1 - 0.18 12.1 0.0 0.45 10.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 CCF39241.1 - 0.22 11.4 0.0 0.41 10.5 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Transcrip_reg PF01709.20 CCF39244.1 - 2.3e-16 60.0 0.0 2.8e-16 59.7 0.0 1.0 1 0 0 1 1 1 1 Transcriptional regulator Pet100 PF09803.9 CCF39246.1 - 2e-18 66.7 1.3 3.7e-18 65.8 1.3 1.5 1 1 0 1 1 1 1 Pet100 GAPT PF11770.8 CCF39246.1 - 0.086 12.7 0.0 0.096 12.5 0.0 1.0 1 0 0 1 1 1 0 GRB2-binding adapter (GAPT) zf-RING_4 PF14570.6 CCF39248.1 - 3.5e-21 74.7 12.2 5.1e-21 74.2 12.2 1.3 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-C3HC4_3 PF13920.6 CCF39248.1 - 6e-09 35.6 7.6 9.7e-09 35.0 7.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Rtf2 PF04641.12 CCF39248.1 - 1.3e-06 28.0 4.4 1.4e-06 27.9 4.4 1.1 1 0 0 1 1 1 1 Rtf2 RING-finger Prok-RING_4 PF14447.6 CCF39248.1 - 1e-05 25.3 9.3 0.00047 20.0 4.4 2.3 1 1 1 2 2 2 2 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 CCF39248.1 - 1.5e-05 25.2 10.0 2.2e-05 24.7 10.0 1.3 1 0 0 1 1 1 1 Ring finger domain FYVE_2 PF02318.16 CCF39248.1 - 0.0021 18.3 4.7 0.0021 18.3 4.7 2.1 1 1 1 2 2 2 1 FYVE-type zinc finger zf-C3HC4 PF00097.25 CCF39248.1 - 0.0031 17.4 9.6 0.0065 16.3 9.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Baculo_IE-1 PF05290.11 CCF39248.1 - 0.004 17.1 5.4 0.004 17.1 5.4 1.6 2 0 0 2 2 2 1 Baculovirus immediate-early protein (IE-0) zf-RING_5 PF14634.6 CCF39248.1 - 0.0058 16.6 9.4 0.012 15.6 9.4 1.6 1 0 0 1 1 1 1 zinc-RING finger domain FYVE PF01363.21 CCF39248.1 - 0.0061 16.7 7.6 0.011 15.8 7.6 1.6 1 1 0 1 1 1 1 FYVE zinc finger Rad50_zn_hook PF04423.14 CCF39248.1 - 0.017 14.9 4.0 0.94 9.4 0.1 2.9 3 0 0 3 3 3 0 Rad50 zinc hook motif zf-UDP PF14569.6 CCF39248.1 - 0.05 13.7 6.8 0.1 12.7 6.8 1.5 1 1 0 1 1 1 0 Zinc-binding RING-finger Peptidase_S55 PF05580.12 CCF39248.1 - 0.071 13.0 0.4 0.084 12.8 0.4 1.1 1 0 0 1 1 1 0 SpoIVB peptidase S55 zf-RING_UBOX PF13445.6 CCF39248.1 - 0.08 13.0 7.5 0.22 11.6 6.0 2.2 1 1 1 2 2 2 0 RING-type zinc-finger zf-C3HC4_2 PF13923.6 CCF39248.1 - 0.11 12.3 11.0 0.33 10.8 11.2 1.7 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 CCF39248.1 - 0.17 12.0 3.2 0.51 10.4 0.9 2.2 1 1 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger EST1 PF10374.9 CCF39248.1 - 0.21 12.3 2.1 0.3 11.7 2.1 1.2 1 0 0 1 1 1 0 Telomerase activating protein Est1 zf-Di19 PF05605.12 CCF39248.1 - 0.56 10.5 4.9 24 5.3 0.0 3.2 2 1 1 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding NOB1_Zn_bind PF08772.11 CCF39248.1 - 1.5 9.0 7.5 0.096 12.9 2.4 1.7 1 1 1 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like CTU2 PF10288.9 CCF39248.1 - 2.4 8.4 10.4 14 6.0 10.4 2.1 1 1 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 zf-C3HC4_4 PF15227.6 CCF39248.1 - 5.1 7.4 12.4 74 3.6 12.4 2.3 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING Complex1_30kDa PF00329.19 CCF39249.1 - 1.6e-46 157.9 0.0 2.1e-46 157.5 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit DUF2087 PF09860.9 CCF39249.1 - 0.065 13.4 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2087) RabGAP-TBC PF00566.18 CCF39251.1 - 6.4e-22 78.3 0.9 1.9e-21 76.7 0.9 1.8 1 1 0 1 1 1 1 Rab-GTPase-TBC domain Pes-10 PF07149.11 CCF39252.1 - 1.3 8.0 11.4 1.8 7.5 11.4 1.1 1 0 0 1 1 1 0 Pes-10 SDA1 PF05285.12 CCF39252.1 - 7.5 5.9 14.2 9.9 5.5 14.2 1.3 1 0 0 1 1 1 0 SDA1 SNF2_N PF00176.23 CCF39253.1 - 1.7e-24 86.2 0.0 2.6e-24 85.6 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.15 CCF39253.1 - 2e-05 24.7 0.0 6.4e-05 23.0 0.0 1.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_34 PF13872.6 CCF39253.1 - 0.056 12.3 0.0 0.21 10.4 0.0 1.8 2 0 0 2 2 2 0 P-loop containing NTP hydrolase pore-1 Anophelin PF10731.9 CCF39253.1 - 0.22 11.4 0.2 0.43 10.5 0.2 1.4 1 0 0 1 1 1 0 Thrombin inhibitor from mosquito TruB_N PF01509.18 CCF39254.1 - 1.4e-22 80.7 0.1 2.4e-19 70.1 0.1 3.4 1 1 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 CCF39254.1 - 1.8e-22 79.2 0.8 3.3e-22 78.4 0.8 1.5 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain PUA PF01472.20 CCF39254.1 - 2e-22 78.9 0.9 3.9e-22 78.0 0.9 1.5 1 0 0 1 1 1 1 PUA domain UPF0113 PF03657.13 CCF39254.1 - 0.00046 20.4 0.0 0.0011 19.1 0.0 1.6 1 0 0 1 1 1 1 UPF0113 PUA domain DKCLD PF08068.12 CCF39254.1 - 0.0058 16.7 0.0 0.26 11.4 0.0 2.6 2 0 0 2 2 2 1 DKCLD (NUC011) domain PseudoU_synth_2 PF00849.22 CCF39254.1 - 0.026 14.6 0.4 0.065 13.3 0.0 1.8 2 0 0 2 2 2 0 RNA pseudouridylate synthase Med19 PF10278.9 CCF39254.1 - 0.31 11.0 10.0 0.66 9.9 10.0 1.4 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 DUF2235 PF09994.9 CCF39255.1 - 1.9e-80 270.3 0.0 2.6e-80 269.8 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) HET PF06985.11 CCF39256.1 - 0.0028 18.0 0.1 0.0032 17.8 0.1 1.2 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) RAI1 PF08652.11 CCF39257.1 - 3e-28 97.8 0.0 1e-27 96.1 0.0 2.0 2 0 0 2 2 2 1 RAI1 like PD-(D/E)XK nuclease Ribosomal_S6e PF01092.19 CCF39257.1 - 0.021 14.8 0.0 0.043 13.8 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein S6e Pkinase PF00069.25 CCF39258.1 - 2.7e-68 230.2 0.0 3.9e-68 229.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF39258.1 - 6.1e-48 163.4 0.0 1.2e-47 162.3 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF39258.1 - 4.9e-06 26.1 0.0 7e-05 22.3 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 CCF39258.1 - 2.2e-05 23.4 0.0 3.8e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 CCF39258.1 - 0.0046 16.0 0.0 0.01 14.8 0.0 1.5 1 1 0 1 1 1 1 Haspin like kinase domain Mannitol_dh_C PF08125.13 CCF39261.1 - 5.3e-74 248.8 0.0 7.3e-74 248.3 0.0 1.2 1 0 0 1 1 1 1 Mannitol dehydrogenase C-terminal domain Mannitol_dh PF01232.23 CCF39261.1 - 1.1e-38 132.7 0.0 3e-38 131.3 0.0 1.8 1 1 0 1 1 1 1 Mannitol dehydrogenase Rossmann domain Memo PF01875.17 CCF39262.1 - 2.4e-71 240.0 0.0 2.9e-71 239.8 0.0 1.0 1 0 0 1 1 1 1 Memo-like protein DUF3638 PF12340.8 CCF39263.1 - 1.6e-94 315.4 0.3 2.6e-94 314.8 0.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3638) DUF3645 PF12359.8 CCF39263.1 - 3.6e-16 58.2 0.1 7.4e-16 57.2 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3645) bVLRF1 PF18826.1 CCF39263.1 - 0.16 11.8 0.1 0.33 10.8 0.1 1.5 1 0 0 1 1 1 0 bacteroidetes VLRF1 release factor LprI PF07007.12 CCF39263.1 - 1 10.0 2.9 5.4 7.7 0.5 2.6 2 0 0 2 2 2 0 Lysozyme inhibitor LprI TEA PF01285.18 CCF39267.1 - 8.7e-27 93.0 0.3 2e-26 91.8 0.3 1.7 1 0 0 1 1 1 1 TEA/ATTS domain Pro_isomerase PF00160.21 CCF39269.1 - 5.4e-32 111.3 0.2 6.5e-32 111.0 0.2 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Thioredoxin_3 PF13192.6 CCF39269.1 - 0.047 13.7 0.0 0.056 13.5 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin domain E1_dh PF00676.20 CCF39269.1 - 0.13 11.2 0.1 0.2 10.6 0.1 1.2 1 0 0 1 1 1 0 Dehydrogenase E1 component DnaJ PF00226.31 CCF39270.1 - 7e-21 74.1 1.8 2.2e-16 59.7 0.5 2.9 2 0 0 2 2 2 2 DnaJ domain zf-C2H2_jaz PF12171.8 CCF39270.1 - 1.5e-09 37.9 2.2 1.5e-09 37.9 2.2 1.8 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CCF39270.1 - 4.9e-08 33.1 7.8 8.5e-08 32.3 1.9 2.5 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 CCF39270.1 - 7.3e-07 29.5 6.0 0.0012 19.2 1.5 2.3 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.26 CCF39270.1 - 5.7e-06 26.5 6.9 0.023 15.1 0.9 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCF39270.1 - 1.2e-05 25.8 4.2 0.071 14.0 0.3 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 CCF39270.1 - 0.0086 16.1 8.4 0.08 13.0 1.6 2.4 2 0 0 2 2 2 2 C2H2-type zinc finger RPT PF13446.6 CCF39270.1 - 0.043 13.8 0.1 0.24 11.4 0.0 2.3 1 1 1 2 2 2 0 A repeated domain in UCH-protein Actin_micro PF17003.5 CCF39270.1 - 0.046 12.9 0.9 0.33 10.1 0.1 2.0 2 0 0 2 2 2 0 Putative actin-like family zf-C2H2_3rep PF18868.1 CCF39270.1 - 0.12 13.1 2.2 21 5.8 0.0 2.6 2 0 0 2 2 2 0 Zinc finger C2H2-type, 3 repeats Lact-deh-memb PF09330.11 CCF39270.1 - 0.27 10.6 1.5 0.46 9.8 1.5 1.3 1 0 0 1 1 1 0 D-lactate dehydrogenase, membrane binding DUF2256 PF10013.9 CCF39270.1 - 0.9 9.7 3.0 17 5.6 0.0 3.0 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2256) Peptidase_C54 PF03416.19 CCF39271.1 - 9.1e-96 320.5 0.0 1.3e-95 320.0 0.0 1.2 1 0 0 1 1 1 1 Peptidase family C54 DHO_dh PF01180.21 CCF39272.1 - 8.4e-68 228.7 0.5 9.6e-57 192.4 0.0 2.1 2 0 0 2 2 2 2 Dihydroorotate dehydrogenase PcrB PF01884.17 CCF39272.1 - 0.0019 17.7 0.7 0.15 11.5 0.1 2.5 2 0 0 2 2 2 2 PcrB family FMN_dh PF01070.18 CCF39272.1 - 0.068 12.2 0.5 0.94 8.4 0.3 2.3 2 0 0 2 2 2 0 FMN-dependent dehydrogenase Mpv17_PMP22 PF04117.12 CCF39273.1 - 3.7e-17 62.3 0.1 9e-17 61.1 0.1 1.7 1 0 0 1 1 1 1 Mpv17 / PMP22 family Glyco_hydro_71 PF03659.14 CCF39274.1 - 4e-137 457.0 3.6 4e-137 457.0 3.6 1.5 2 0 0 2 2 2 1 Glycosyl hydrolase family 71 Pkinase PF00069.25 CCF39278.1 - 8.9e-50 169.5 0.0 1.4e-49 168.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF39278.1 - 1.9e-27 96.2 0.0 2.7e-27 95.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF39278.1 - 0.00035 20.0 0.0 0.00094 18.6 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 CCF39278.1 - 0.022 14.1 0.0 0.038 13.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CCF39278.1 - 0.083 12.8 0.1 0.73 9.7 0.0 2.4 2 1 1 3 3 3 0 Phosphotransferase enzyme family RIO1 PF01163.22 CCF39278.1 - 0.093 12.3 0.0 0.21 11.2 0.0 1.6 1 1 0 1 1 1 0 RIO1 family GST_N_2 PF13409.6 CCF39280.1 - 1.3e-09 38.2 0.1 5.3e-09 36.2 0.1 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 CCF39280.1 - 0.0057 17.0 0.3 0.011 16.1 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain Anophelin PF10731.9 CCF39281.1 - 3.1 7.7 4.1 1.9 8.4 0.6 2.2 2 1 0 2 2 2 0 Thrombin inhibitor from mosquito SRP9-21 PF05486.12 CCF39282.1 - 2.5e-37 127.2 2.3 3.2e-37 126.8 2.3 1.1 1 0 0 1 1 1 1 Signal recognition particle 9 kDa protein (SRP9) Ribonuc_red_sm PF00268.21 CCF39283.1 - 3.6e-122 407.2 2.3 4.6e-122 406.8 2.3 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain ABC_membrane PF00664.23 CCF39284.1 - 8.3e-55 186.4 9.0 1.2e-54 185.8 9.0 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 CCF39284.1 - 2.1e-44 151.4 0.1 3.4e-33 115.1 0.0 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 CCF39284.1 - 2.9e-13 49.8 3.0 4.2e-05 23.1 0.0 3.5 2 1 1 3 3 3 3 RecF/RecN/SMC N terminal domain AAA PF00004.29 CCF39284.1 - 0.00054 20.4 0.8 10 6.6 0.0 3.6 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) SbcCD_C PF13558.6 CCF39284.1 - 0.0011 19.1 0.4 1.7 8.9 0.4 3.5 2 1 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_22 PF13401.6 CCF39284.1 - 0.0026 18.0 0.1 0.019 15.3 0.0 2.4 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 CCF39284.1 - 0.003 18.0 0.0 0.012 16.0 0.0 2.0 1 1 0 1 1 1 1 AAA ATPase domain ABC_ATPase PF09818.9 CCF39284.1 - 0.0099 14.7 0.3 0.13 11.1 0.0 2.4 3 0 0 3 3 3 1 Predicted ATPase of the ABC class AAA_15 PF13175.6 CCF39284.1 - 0.029 14.1 0.8 0.035 13.8 0.0 1.5 2 0 0 2 2 2 0 AAA ATPase domain CRCB PF02537.15 CCF39284.1 - 0.07 13.4 0.3 0.25 11.7 0.3 2.0 1 0 0 1 1 1 0 CrcB-like protein, Camphor Resistance (CrcB) RsgA_GTPase PF03193.16 CCF39284.1 - 0.073 13.0 0.0 0.48 10.3 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase AAA_5 PF07728.14 CCF39284.1 - 0.12 12.4 0.1 1 9.4 0.0 2.5 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 CCF39284.1 - 0.14 11.7 0.3 0.8 9.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain ATP-synt_ab PF00006.25 CCF39284.1 - 0.15 11.7 0.0 0.38 10.4 0.0 1.8 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain Hydrolase_4 PF12146.8 CCF39285.1 - 2.3e-13 50.0 0.2 7e-13 48.4 0.1 1.8 1 1 1 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CCF39285.1 - 1.6e-12 48.5 4.4 2.2e-12 48.1 4.4 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CCF39285.1 - 4.5e-12 46.2 0.1 1.3e-11 44.6 0.1 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.7 CCF39285.1 - 0.016 15.0 0.0 0.047 13.4 0.0 1.7 2 0 0 2 2 2 0 Alpha/beta hydrolase family Ndr PF03096.14 CCF39285.1 - 0.027 13.2 0.1 0.08 11.6 0.1 1.7 1 1 0 1 1 1 0 Ndr family UPF0227 PF05728.12 CCF39285.1 - 0.063 13.2 0.0 0.35 10.8 0.0 2.0 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0227) Lipase_3 PF01764.25 CCF39285.1 - 0.07 13.0 0.1 0.12 12.2 0.1 1.4 1 0 0 1 1 1 0 Lipase (class 3) DLH PF01738.18 CCF39285.1 - 0.13 11.8 0.0 0.7 9.4 0.0 2.2 2 1 0 2 2 2 0 Dienelactone hydrolase family PGAP1 PF07819.13 CCF39285.1 - 0.16 11.6 0.1 1.2 8.8 0.0 2.0 2 0 0 2 2 2 0 PGAP1-like protein Pyrid_oxidase_2 PF13883.6 CCF39287.1 - 2.2e-40 138.4 0.0 3.5e-40 137.8 0.0 1.3 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase F-box-like PF12937.7 CCF39288.1 - 0.037 13.9 0.0 0.57 10.1 0.0 2.7 2 0 0 2 2 2 0 F-box-like Ribosomal_S30 PF04758.14 CCF39289.1 - 1.2e-29 102.3 8.0 1.3e-29 102.1 8.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S30 RRP14 PF15459.6 CCF39291.1 - 9e-17 61.4 1.0 9e-17 61.4 1.0 4.5 4 1 0 4 4 4 1 60S ribosome biogenesis protein Rrp14 POPLD PF08170.12 CCF39291.1 - 2.9 8.3 0.0 2.9 8.3 0.0 3.6 3 2 2 5 5 5 0 POPLD (NUC188) domain Red1 PF07964.11 CCF39291.1 - 7.9 4.6 34.9 9.8 4.3 34.9 1.1 1 0 0 1 1 1 0 Rec10 / Red1 HUN PF08729.10 CCF39292.1 - 1.8e-07 31.0 0.7 4.4e-07 29.8 0.7 1.6 1 0 0 1 1 1 1 HPC2 and ubinuclein domain PIG-U PF06728.13 CCF39294.1 - 2.8e-124 415.0 24.7 3.2e-124 414.8 24.7 1.0 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U Mannosyl_trans PF05007.13 CCF39294.1 - 0.00013 21.9 0.2 0.00013 21.9 0.2 1.7 1 1 0 1 1 1 1 Mannosyltransferase (PIG-M) 8TM_micro PF17028.5 CCF39294.1 - 0.3 10.7 8.3 1.3 8.6 8.3 2.0 1 1 0 1 1 1 0 8TM Microsporidial transmembrane domain Pescadillo_N PF06732.11 CCF39295.1 - 6.6e-124 412.9 0.2 1e-123 412.2 0.2 1.2 1 0 0 1 1 1 1 Pescadillo N-terminus BRCT PF00533.26 CCF39295.1 - 1.1e-05 25.7 0.1 5.4e-05 23.5 0.0 2.2 3 0 0 3 3 3 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 CCF39295.1 - 0.00051 20.4 0.1 0.0028 18.0 0.1 2.2 1 1 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain 3-dmu-9_3-mt PF06983.13 CCF39295.1 - 0.042 14.4 0.1 0.08 13.5 0.1 1.4 1 0 0 1 1 1 0 3-demethylubiquinone-9 3-methyltransferase Astro_capsid_p PF12226.8 CCF39295.1 - 0.68 9.0 12.0 0.14 11.2 1.1 2.2 2 0 0 2 2 2 0 Turkey astrovirus capsid protein DUF3138 PF11336.8 CCF39296.1 - 3.2 6.2 10.1 0.026 13.2 1.4 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3138) Voldacs PF03517.13 CCF39297.1 - 6.5e-19 68.4 0.1 2.1e-18 66.8 0.1 1.8 1 1 0 1 1 1 1 Regulator of volume decrease after cellular swelling SMI1_KNR4 PF09346.10 CCF39299.1 - 2.3e-11 44.2 0.0 3.6e-11 43.6 0.0 1.4 1 0 0 1 1 1 1 SMI1 / KNR4 family (SUKH-1) SUKH_5 PF14567.6 CCF39299.1 - 0.14 11.9 0.0 0.25 11.1 0.0 1.4 1 0 0 1 1 1 0 SMI1-KNR4 cell-wall Dynamin_N PF00350.23 CCF39301.1 - 5.4e-14 52.6 0.0 3.7e-13 49.9 0.0 2.3 1 1 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 CCF39301.1 - 1.5e-06 28.3 0.1 7.7e-05 22.7 0.1 2.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_23 PF13476.6 CCF39301.1 - 0.00076 20.0 4.4 0.17 12.4 0.0 3.3 3 0 0 3 3 3 1 AAA domain RsgA_GTPase PF03193.16 CCF39301.1 - 0.00081 19.3 0.2 0.0027 17.6 0.0 2.0 2 0 0 2 2 2 1 RsgA GTPase ABC_tran PF00005.27 CCF39301.1 - 0.0016 18.9 0.1 0.0071 16.9 0.0 2.0 1 1 0 1 1 1 1 ABC transporter IIGP PF05049.13 CCF39301.1 - 0.024 13.7 0.0 0.089 11.8 0.0 1.9 2 0 0 2 2 2 0 Interferon-inducible GTPase (IIGP) Roc PF08477.13 CCF39301.1 - 0.072 13.3 0.1 0.29 11.4 0.0 2.0 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 CCF39301.1 - 0.092 12.5 0.1 1.1 9.0 0.0 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain Pro_racemase PF05544.11 CCF39302.1 - 0.049 12.7 0.1 0.049 12.7 0.1 1.1 1 0 0 1 1 1 0 Proline racemase Sec1 PF00995.23 CCF39303.1 - 2e-92 311.3 0.0 2.5e-92 311.0 0.0 1.0 1 0 0 1 1 1 1 Sec1 family AMP-binding PF00501.28 CCF39305.1 - 5.2e-131 437.1 0.0 2.1e-79 267.1 0.1 2.1 2 0 0 2 2 2 2 AMP-binding enzyme Condensation PF00668.20 CCF39305.1 - 9.1e-84 281.7 0.0 1.4e-83 281.1 0.0 1.1 1 0 0 1 1 1 1 Condensation domain PP-binding PF00550.25 CCF39305.1 - 3.6e-12 46.4 0.1 1.3e-11 44.7 0.0 2.0 2 0 0 2 2 2 1 Phosphopantetheine attachment site AMP-binding_C PF13193.6 CCF39305.1 - 0.11 13.5 1.5 27 5.8 0.0 3.1 2 0 0 2 2 2 0 AMP-binding enzyme C-terminal domain Peptidase_S8 PF00082.22 CCF39307.1 - 2.2e-35 122.4 2.5 2.2e-35 122.4 2.5 1.5 2 0 0 2 2 2 1 Subtilase family P_proprotein PF01483.20 CCF39307.1 - 1.3e-28 98.8 2.9 1.8e-28 98.4 1.5 2.0 2 0 0 2 2 2 1 Proprotein convertase P-domain S8_pro-domain PF16470.5 CCF39307.1 - 0.0073 17.1 0.0 0.022 15.5 0.0 1.9 1 0 0 1 1 1 1 Peptidase S8 pro-domain PhoD PF09423.10 CCF39308.1 - 1.1e-07 31.2 0.0 3.1e-07 29.7 0.0 1.6 1 1 0 1 1 1 1 PhoD-like phosphatase Heme_oxygenase PF01126.20 CCF39310.1 - 7.2e-07 29.2 0.0 1.3e-05 25.1 0.0 2.0 2 0 0 2 2 2 1 Heme oxygenase Peptidase_M3_N PF08439.10 CCF39310.1 - 0.028 14.7 0.1 0.057 13.7 0.1 1.5 1 0 0 1 1 1 0 Oligopeptidase F WD40 PF00400.32 CCF39311.1 - 1.3e-05 25.9 0.2 0.095 13.6 0.0 4.2 4 0 0 4 4 4 2 WD domain, G-beta repeat Glyco_hydro_31 PF01055.26 CCF39312.1 - 5e-146 487.3 3.9 6.3e-146 487.0 3.9 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 CCF39312.1 - 7.1e-32 110.0 0.0 1.2e-31 109.3 0.0 1.4 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase 7tm_2 PF00002.24 CCF39314.1 - 8.7e-06 25.2 12.8 8.7e-06 25.2 12.8 1.8 1 1 1 2 2 2 1 7 transmembrane receptor (Secretin family) Dicty_CAR PF05462.11 CCF39314.1 - 0.0032 16.6 3.6 0.0032 16.6 3.6 1.8 1 1 1 2 2 2 1 Slime mold cyclic AMP receptor Saf_2TM PF18303.1 CCF39314.1 - 0.0039 16.8 0.2 0.24 11.0 0.0 3.2 3 0 0 3 3 3 1 SAVED-fused 2TM effector domain EF-hand_7 PF13499.6 CCF39317.1 - 2e-09 37.8 0.0 4.1e-09 36.8 0.0 1.5 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 CCF39317.1 - 2.2e-07 29.9 0.0 0.0044 16.5 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 CCF39317.1 - 4e-06 26.3 0.0 0.035 14.0 0.0 2.7 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 CCF39317.1 - 1.3e-05 24.9 0.0 2.2e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_4 PF12763.7 CCF39317.1 - 0.011 15.7 0.0 0.018 15.0 0.0 1.3 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 CCF39317.1 - 0.1 13.0 0.0 0.19 12.1 0.0 1.5 1 1 0 1 1 1 0 EF-hand domain WSC PF01822.19 CCF39318.1 - 2.4e-53 178.3 33.7 3.8e-19 68.7 10.0 3.6 3 0 0 3 3 3 3 WSC domain DUF1922 PF09082.10 CCF39318.1 - 0.62 10.4 3.8 1.1 9.6 0.8 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF1922) DUF4667 PF15700.5 CCF39318.1 - 2.5 8.1 13.7 0.066 13.3 6.4 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4667) Glyco_transf_34 PF05637.12 CCF39320.1 - 4e-72 242.8 0.0 4.9e-72 242.5 0.0 1.0 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family RINGv PF12906.7 CCF39321.1 - 4.5e-10 39.5 2.4 1.5e-09 37.8 0.5 2.2 2 0 0 2 2 2 1 RING-variant domain PHD_4 PF16866.5 CCF39321.1 - 0.074 13.2 1.0 4.3 7.5 0.0 2.4 1 1 1 2 2 2 0 PHD-finger ZYG-11_interact PF05884.12 CCF39321.1 - 0.19 11.1 0.4 0.28 10.6 0.4 1.2 1 0 0 1 1 1 0 Interactor of ZYG-11 Proteasome_A_N PF10584.9 CCF39322.1 - 1.5e-11 43.8 0.0 1.9e-11 43.4 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Fungal_trans_2 PF11951.8 CCF39323.1 - 7.4e-05 21.7 0.0 0.00012 21.0 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Plasmod_dom_1 PF09715.10 CCF39323.1 - 0.15 12.2 0.2 1.1 9.4 0.1 2.2 2 0 0 2 2 2 0 Plasmodium protein of unknown function (Plasmod_dom_1) FAD_binding_4 PF01565.23 CCF39324.1 - 1.6e-20 73.2 0.1 2.1e-20 72.9 0.1 1.1 1 0 0 1 1 1 1 FAD binding domain Oxidored_FMN PF00724.20 CCF39325.1 - 1.2e-89 301.0 0.0 1.4e-89 300.8 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family ADH_zinc_N_2 PF13602.6 CCF39327.1 - 0.00032 21.7 0.0 0.00034 21.7 0.0 1.1 1 0 0 1 1 1 1 Zinc-binding dehydrogenase CPSase_sm_chain PF00988.22 CCF39327.1 - 0.044 13.6 0.0 0.079 12.8 0.0 1.4 2 0 0 2 2 2 0 Carbamoyl-phosphate synthase small chain, CPSase domain Aldo_ket_red PF00248.21 CCF39327.1 - 0.066 12.4 0.1 0.07 12.3 0.1 1.1 1 0 0 1 1 1 0 Aldo/keto reductase family Sipho_tail PF05709.11 CCF39327.1 - 0.12 11.7 0.1 0.13 11.6 0.1 1.2 1 0 0 1 1 1 0 Phage tail protein Iso_dh PF00180.20 CCF39328.1 - 3.4e-98 329.0 0.0 5.6e-98 328.3 0.0 1.3 1 1 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Pmp3 PF01679.17 CCF39329.1 - 3.9e-06 27.0 0.1 6e-06 26.4 0.1 1.2 1 0 0 1 1 1 1 Proteolipid membrane potential modulator GTP_EFTU PF00009.27 CCF39330.1 - 3e-59 199.8 0.2 5.4e-59 199.0 0.2 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.6 CCF39330.1 - 5.8e-33 112.8 0.0 1.2e-32 111.9 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_IV PF03764.18 CCF39330.1 - 8.7e-33 112.7 0.0 1.7e-32 111.7 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.24 CCF39330.1 - 4.4e-23 81.1 0.0 9e-23 80.1 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 CCF39330.1 - 6.4e-14 52.1 0.0 1.5e-13 51.0 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 CCF39330.1 - 2.2e-07 30.8 0.0 4.8e-07 29.7 0.0 1.6 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain MMR_HSR1 PF01926.23 CCF39330.1 - 0.13 12.3 0.1 0.28 11.3 0.1 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase DUF3328 PF11807.8 CCF39331.1 - 9.4e-21 74.6 0.0 1.2e-20 74.2 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) CRAL_TRIO PF00650.20 CCF39332.1 - 9.2e-26 90.5 0.0 1.4e-25 89.9 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 CCF39332.1 - 2.9e-09 37.0 0.0 7.1e-09 35.7 0.0 1.6 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain DUF1179 PF06678.11 CCF39332.1 - 0.099 12.6 1.6 0.27 11.2 0.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1179) Acid_PPase PF12689.7 CCF39333.1 - 3.6e-64 215.7 0.0 4.3e-64 215.4 0.0 1.1 1 0 0 1 1 1 1 Acid Phosphatase ThrE PF06738.12 CCF39334.1 - 4.2e-67 226.0 18.0 2.6e-66 223.4 3.9 2.6 3 0 0 3 3 3 2 Putative threonine/serine exporter ThrE_2 PF12821.7 CCF39334.1 - 1.1e-07 32.1 25.1 9.3e-06 25.8 0.5 4.1 4 0 0 4 4 4 3 Threonine/Serine exporter, ThrE NPR2 PF06218.11 CCF39334.1 - 0.11 11.2 0.0 0.17 10.6 0.0 1.3 1 0 0 1 1 1 0 Nitrogen permease regulator 2 FA_desaturase PF00487.24 CCF39336.1 - 4.3e-16 59.5 5.0 5.3e-16 59.2 5.0 1.1 1 0 0 1 1 1 1 Fatty acid desaturase AnfG_VnfG PF03139.15 CCF39338.1 - 0.0052 16.9 0.3 0.0079 16.3 0.3 1.3 1 0 0 1 1 1 1 Vanadium/alternative nitrogenase delta subunit HATPase_c_3 PF13589.6 CCF39339.1 - 1.6e-16 60.4 0.0 2.6e-16 59.7 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 CCF39339.1 - 0.057 13.9 0.0 0.18 12.3 0.0 1.9 2 0 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PI3_PI4_kinase PF00454.27 CCF39341.1 - 1e-49 169.6 0.1 5.8e-49 167.2 0.0 2.1 2 0 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.23 CCF39341.1 - 4.8e-12 45.8 11.2 4.8e-12 45.8 11.2 1.8 2 0 0 2 2 2 1 FAT domain FATC PF02260.20 CCF39341.1 - 7.2e-12 44.9 0.1 1.8e-11 43.6 0.1 1.7 1 0 0 1 1 1 1 FATC domain Mac PF12464.8 CCF39342.1 - 1.6e-11 44.3 0.0 2.9e-11 43.4 0.0 1.4 1 0 0 1 1 1 1 Maltose acetyltransferase Hexapep PF00132.24 CCF39342.1 - 2.8e-11 42.7 11.0 4e-10 39.0 2.3 3.3 3 1 0 3 3 3 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 CCF39342.1 - 1.6e-09 37.3 12.7 1.3e-08 34.4 1.6 3.3 3 1 1 4 4 4 3 Hexapeptide repeat of succinyl-transferase ACT_6 PF13740.6 CCF39342.1 - 0.1 12.6 0.0 0.22 11.5 0.0 1.6 1 0 0 1 1 1 0 ACT domain Exo5 PF09810.9 CCF39343.1 - 9.1e-137 456.4 0.0 1.1e-136 456.2 0.0 1.1 1 0 0 1 1 1 1 Exonuclease V - a 5' deoxyribonuclease PDDEXK_1 PF12705.7 CCF39343.1 - 0.0064 16.4 0.1 0.68 9.8 0.0 2.8 2 1 0 2 2 2 1 PD-(D/E)XK nuclease superfamily CFAP91 PF14738.6 CCF39343.1 - 0.073 13.1 0.2 0.17 11.9 0.2 1.6 1 1 0 1 1 1 0 Cilia- and flagella-associated protein 91 PIG-S PF10510.9 CCF39345.1 - 1.3e-170 568.7 0.1 1.5e-170 568.5 0.1 1.0 1 0 0 1 1 1 1 Phosphatidylinositol-glycan biosynthesis class S protein PALP PF00291.25 CCF39346.1 - 6.3e-66 222.8 0.2 7.9e-66 222.4 0.2 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CBS PF00571.28 CCF39346.1 - 2.3e-12 47.1 0.0 7.3e-09 36.0 0.0 2.9 2 0 0 2 2 2 2 CBS domain SRPRB PF09439.10 CCF39347.1 - 3.7e-28 98.2 0.0 8.7e-28 97.0 0.0 1.6 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 CCF39347.1 - 2.1e-05 24.6 0.0 3.2e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.6 CCF39347.1 - 0.00056 20.2 0.0 0.0011 19.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CCF39347.1 - 0.0006 20.2 0.3 0.0012 19.3 0.3 1.7 1 1 0 1 1 1 1 AAA ATPase domain Arf PF00025.21 CCF39347.1 - 0.0024 17.4 0.0 0.13 11.7 0.0 2.5 1 1 0 1 1 1 1 ADP-ribosylation factor family Septin PF00735.18 CCF39347.1 - 0.0024 17.2 0.0 0.0047 16.2 0.0 1.4 2 0 0 2 2 2 1 Septin AAA PF00004.29 CCF39347.1 - 0.012 16.0 0.1 0.072 13.5 0.1 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) SRP54 PF00448.22 CCF39347.1 - 0.019 14.6 0.1 1.1 8.8 0.0 2.2 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain Roc PF08477.13 CCF39347.1 - 0.021 15.0 0.0 0.06 13.6 0.0 1.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase TniB PF05621.11 CCF39347.1 - 0.033 13.6 0.0 0.056 12.8 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein cobW PF02492.19 CCF39347.1 - 0.042 13.4 0.2 4.4 6.8 0.4 2.2 1 1 1 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain GTP_EFTU PF00009.27 CCF39347.1 - 0.049 13.2 0.0 0.47 10.0 0.0 2.1 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain ABC_tran PF00005.27 CCF39347.1 - 0.057 13.9 0.0 0.089 13.3 0.0 1.3 1 0 0 1 1 1 0 ABC transporter AAA_30 PF13604.6 CCF39347.1 - 0.11 12.2 0.3 0.2 11.4 0.3 1.4 1 1 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 CCF39347.1 - 0.13 12.1 0.2 0.66 9.9 0.2 2.0 2 0 0 2 2 2 0 RsgA GTPase Ras PF00071.22 CCF39347.1 - 0.16 11.6 0.0 0.54 9.8 0.0 1.8 2 0 0 2 2 2 0 Ras family Gtr1_RagA PF04670.12 CCF39347.1 - 0.23 10.8 0.0 0.45 9.8 0.0 1.5 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region DHHC PF01529.20 CCF39348.1 - 1.4e-36 125.5 13.0 1.4e-36 125.5 13.0 1.9 2 0 0 2 2 2 1 DHHC palmitoyltransferase Ank_2 PF12796.7 CCF39348.1 - 1.7e-27 95.8 0.0 1.6e-12 47.8 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CCF39348.1 - 1.4e-24 86.1 0.3 3.4e-06 27.5 0.2 4.6 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 CCF39348.1 - 1.1e-22 79.8 0.1 1.5e-07 31.5 0.0 5.5 3 2 2 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 CCF39348.1 - 2.3e-21 75.2 0.3 0.0023 18.3 0.0 5.5 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.6 CCF39348.1 - 3.2e-20 70.1 0.4 8.7e-05 22.6 0.0 5.9 5 0 0 5 5 5 4 Ankyrin repeat Vps62 PF06101.11 CCF39350.1 - 2.3e-11 42.7 0.4 2.3e-11 42.7 0.4 1.7 2 0 0 2 2 2 1 Vacuolar protein sorting-associated protein 62 TFIIIC_sub6 PF10419.9 CCF39351.1 - 3.2e-22 78.2 0.0 5.2e-22 77.5 0.0 1.3 1 0 0 1 1 1 1 TFIIIC subunit triple barrel domain Glyco_transf_8 PF01501.20 CCF39352.1 - 0.0004 20.0 0.0 0.00047 19.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 8 SNF2_N PF00176.23 CCF39353.1 - 9.1e-51 172.6 0.2 1.4e-50 171.9 0.2 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain VIGSSK PF14773.6 CCF39353.1 - 2.5e-25 88.4 3.1 8.4e-25 86.7 3.1 2.0 1 0 0 1 1 1 1 Helicase-associated putative binding domain, C-terminal Helicase_C PF00271.31 CCF39353.1 - 2.5e-19 69.7 0.0 3.8e-18 65.8 0.0 2.7 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 CCF39353.1 - 9.1e-08 31.6 0.0 5.5e-07 29.1 0.0 2.2 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase ResIII PF04851.15 CCF39353.1 - 1.3e-07 31.8 0.0 1.2e-06 28.6 0.0 2.6 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_34 PF13872.6 CCF39353.1 - 0.04 12.8 1.1 4.8 6.0 0.1 2.4 2 0 0 2 2 2 0 P-loop containing NTP hydrolase pore-1 HDA2-3 PF11496.8 CCF39353.1 - 0.047 12.9 0.0 0.5 9.5 0.0 2.5 2 0 0 2 2 2 0 Class II histone deacetylase complex subunits 2 and 3 TruD PF01142.18 CCF39354.1 - 5e-65 219.9 0.0 4e-59 200.5 0.0 3.1 3 0 0 3 3 3 3 tRNA pseudouridine synthase D (TruD) Vfa1 PF08432.10 CCF39354.1 - 0.67 10.3 6.4 0.64 10.3 1.7 2.7 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Pkinase PF00069.25 CCF39355.1 - 1.5e-15 57.3 0.0 1.7e-15 57.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF39355.1 - 2.6e-06 26.9 0.0 3.3e-06 26.6 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Glyco_trans_1_4 PF13692.6 CCF39356.1 - 6.9e-07 29.8 0.0 2.3e-06 28.0 0.0 1.9 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 CCF39356.1 - 2.6e-06 27.1 0.0 7.2e-06 25.7 0.0 1.8 2 1 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 CCF39356.1 - 0.0015 18.9 0.0 0.0031 17.9 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 GMC_oxred_C PF05199.13 CCF39357.1 - 2.4e-22 80.0 0.2 3.1e-22 79.6 0.2 1.2 1 0 0 1 1 1 1 GMC oxidoreductase Condensation PF00668.20 CCF39358.1 - 3.2e-83 279.9 0.0 4.3e-83 279.5 0.0 1.1 1 0 0 1 1 1 1 Condensation domain AMP-binding PF00501.28 CCF39358.1 - 3.4e-72 243.4 0.1 4.5e-72 243.0 0.1 1.2 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.25 CCF39358.1 - 2.7e-13 50.1 0.3 7.6e-13 48.6 0.3 1.9 1 0 0 1 1 1 1 Phosphopantetheine attachment site AMP-binding_C PF13193.6 CCF39358.1 - 5.8e-07 30.4 0.1 0.0056 17.6 0.2 3.0 2 0 0 2 2 2 2 AMP-binding enzyme C-terminal domain Methyltransf_25 PF13649.6 CCF39358.1 - 9.2e-07 29.5 0.0 3.4e-06 27.7 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF39358.1 - 2.1e-06 27.6 0.0 4.7e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF39358.1 - 1.5e-05 25.6 0.0 4.7e-05 23.9 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF39358.1 - 2.4e-05 25.0 0.0 6.1e-05 23.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF39358.1 - 0.00036 20.4 0.0 0.0011 18.8 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain PRMT5_TIM PF17285.2 CCF39359.1 - 1.4e-43 149.0 0.0 1.6e-43 148.8 0.0 1.0 1 0 0 1 1 1 1 PRMT5 TIM barrel domain OB_NTP_bind PF07717.16 CCF39360.1 - 4.6e-22 78.2 0.2 7.3e-21 74.3 0.0 2.7 3 0 0 3 3 3 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 CCF39360.1 - 3.6e-17 62.6 0.0 9.9e-17 61.2 0.0 1.8 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 CCF39360.1 - 3.2e-11 43.6 0.0 1.9e-10 41.0 0.0 2.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DEAD PF00270.29 CCF39360.1 - 1.8e-08 34.4 0.1 3.6e-08 33.4 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 CCF39360.1 - 5.4e-06 26.7 0.0 1.4e-05 25.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 CCF39360.1 - 1.5e-05 24.8 0.1 6.4e-05 22.7 0.1 1.9 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain T2SSE PF00437.20 CCF39360.1 - 0.00049 19.2 0.0 0.00093 18.3 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_30 PF13604.6 CCF39360.1 - 0.0021 17.8 0.0 0.0037 17.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CCF39360.1 - 0.0074 16.6 0.1 0.016 15.5 0.1 1.5 1 0 0 1 1 1 1 AAA domain Flavi_DEAD PF07652.14 CCF39360.1 - 0.021 14.8 0.1 0.046 13.7 0.1 1.5 1 0 0 1 1 1 0 Flavivirus DEAD domain ResIII PF04851.15 CCF39360.1 - 0.022 14.7 0.1 3.4 7.7 0.0 2.4 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit DUF2075 PF09848.9 CCF39360.1 - 0.025 13.9 0.0 0.038 13.2 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_23 PF13476.6 CCF39360.1 - 0.055 14.0 0.0 0.11 12.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain Exc PF07825.11 CCF39364.1 - 0.014 15.4 0.0 0.034 14.1 0.0 1.6 1 0 0 1 1 1 0 Excisionase-like protein MIF PF01187.18 CCF39367.1 - 4.7e-11 43.0 0.0 7.4e-11 42.3 0.0 1.3 1 0 0 1 1 1 1 Macrophage migration inhibitory factor (MIF) Gtr1_RagA PF04670.12 CCF39368.1 - 3.3e-70 236.0 0.1 4.1e-70 235.7 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Roc PF08477.13 CCF39368.1 - 0.019 15.2 0.0 0.042 14.1 0.0 1.7 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 CCF39368.1 - 0.023 14.2 0.0 0.039 13.5 0.0 1.3 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 CCF39368.1 - 0.037 14.4 0.0 0.09 13.1 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain MMR_HSR1 PF01926.23 CCF39368.1 - 0.12 12.5 0.0 0.24 11.5 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase ANAPC4 PF12896.7 CCF39369.1 - 3.2e-70 235.8 0.0 5.1e-70 235.1 0.0 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 4 ANAPC4_WD40 PF12894.7 CCF39369.1 - 5.7e-11 42.6 0.0 2.9e-10 40.3 0.0 2.2 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CCF39369.1 - 0.065 14.1 0.0 0.76 10.8 0.0 3.0 1 0 0 1 1 1 0 WD domain, G-beta repeat Adap_comp_sub PF00928.21 CCF39370.1 - 1.4e-17 63.9 0.2 2.2e-17 63.3 0.2 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 CCF39370.1 - 3.4e-08 33.5 0.1 5.9e-08 32.8 0.1 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain RPM2 PF08579.11 CCF39370.1 - 0.0072 16.7 0.3 0.015 15.7 0.3 1.5 1 0 0 1 1 1 1 Mitochondrial ribonuclease P subunit (RPM2) DUF2420 PF10336.9 CCF39371.1 - 4.6e-11 42.7 0.0 1e-10 41.6 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2420) ExbD PF02472.16 CCF39371.1 - 0.13 12.4 0.4 0.49 10.6 0.1 2.2 2 0 0 2 2 2 0 Biopolymer transport protein ExbD/TolR Pkinase PF00069.25 CCF39373.1 - 3.9e-33 114.9 0.0 5.5e-33 114.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF39373.1 - 2.1e-15 56.7 0.0 3.8e-15 55.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF39373.1 - 0.00027 20.4 0.0 0.00045 19.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 CCF39373.1 - 0.052 13.5 0.0 0.14 12.0 0.0 1.6 1 1 1 2 2 2 0 Phosphotransferase enzyme family TauD PF02668.16 CCF39374.1 - 1.5e-18 67.6 0.2 2e-18 67.2 0.2 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family CsiD PF08943.10 CCF39374.1 - 0.0074 15.4 0.2 0.011 14.9 0.2 1.1 1 0 0 1 1 1 1 CsiD Fungal_trans_2 PF11951.8 CCF39375.1 - 3e-30 105.3 0.7 4.4e-18 65.2 0.1 2.2 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF39375.1 - 7.9e-09 35.5 12.2 1.8e-08 34.3 12.2 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AT_hook PF02178.19 CCF39375.1 - 0.069 13.1 5.4 0.21 11.6 5.4 1.9 1 0 0 1 1 1 0 AT hook motif ketoacyl-synt PF00109.26 CCF39376.1 - 3.8e-71 239.6 0.0 1.5e-70 237.6 0.0 2.1 3 0 0 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 CCF39376.1 - 1.1e-30 106.1 0.9 5.4e-30 103.8 0.0 2.6 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Acyl_transf_1 PF00698.21 CCF39376.1 - 4.3e-28 98.8 0.4 7.4e-28 98.0 0.4 1.3 1 0 0 1 1 1 1 Acyl transferase domain KAsynt_C_assoc PF16197.5 CCF39376.1 - 1.7e-14 54.3 0.0 4.1e-14 53.0 0.0 1.6 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Thiolase_N PF00108.23 CCF39376.1 - 0.00021 20.7 0.0 0.0004 19.8 0.0 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain RGS PF00615.19 CCF39378.1 - 5.2e-05 23.5 0.0 0.00027 21.2 0.0 2.0 1 1 0 1 1 1 1 Regulator of G protein signaling domain Meth_synt_2 PF01717.18 CCF39379.1 - 7.8e-08 31.9 0.0 2e-06 27.3 0.0 2.6 2 1 0 2 2 2 1 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.12 CCF39379.1 - 0.0049 16.4 0.1 0.02 14.4 0.0 2.0 3 0 0 3 3 3 1 Cobalamin-independent synthase, N-terminal domain Spt20 PF12090.8 CCF39380.1 - 0.058 13.0 3.8 0.053 13.1 3.8 1.1 1 0 0 1 1 1 0 Spt20 family Androgen_recep PF02166.16 CCF39380.1 - 0.073 11.9 5.3 0.074 11.9 5.3 1.0 1 0 0 1 1 1 0 Androgen receptor PMM PF03332.13 CCF39381.1 - 9.3e-101 336.2 0.2 1.1e-100 336.0 0.2 1.0 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase Hydrolase_3 PF08282.12 CCF39381.1 - 0.0072 16.1 0.0 0.065 13.0 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 CCF39381.1 - 0.12 12.8 0.0 4.6 7.6 0.0 2.8 3 0 0 3 3 3 0 haloacid dehalogenase-like hydrolase DUF4834 PF16118.5 CCF39382.1 - 0.14 13.1 0.0 0.18 12.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) RIX1 PF08167.12 CCF39384.1 - 3.1e-64 216.2 0.0 7e-64 215.0 0.1 1.6 2 0 0 2 2 2 1 rRNA processing/ribosome biogenesis PPP4R2 PF09184.11 CCF39384.1 - 2.9 7.4 9.2 5.5 6.5 9.2 1.5 1 0 0 1 1 1 0 PPP4R2 Epimerase PF01370.21 CCF39385.1 - 3e-14 53.1 0.0 7e-14 51.9 0.0 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CCF39385.1 - 2.2e-11 43.3 0.0 4.2e-11 42.4 0.0 1.4 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 CCF39385.1 - 3.4e-10 39.9 0.0 1.9e-09 37.4 0.0 2.0 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 CCF39385.1 - 4.2e-10 39.8 0.0 1.4e-09 38.1 0.0 1.8 2 0 0 2 2 2 1 NAD(P)H-binding adh_short PF00106.25 CCF39385.1 - 1e-06 28.3 0.1 0.00035 20.1 0.0 3.0 3 0 0 3 3 3 1 short chain dehydrogenase NmrA PF05368.13 CCF39385.1 - 2.8e-06 27.1 0.0 4.5e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family NAD_binding_4 PF07993.12 CCF39385.1 - 1.3e-05 24.5 0.0 0.00036 19.8 0.0 2.1 2 0 0 2 2 2 1 Male sterility protein Polysacc_synt_2 PF02719.15 CCF39385.1 - 0.00028 20.1 0.0 0.00049 19.3 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 CCF39385.1 - 0.01 15.0 0.0 0.056 12.5 0.0 2.1 2 1 0 2 2 2 0 RmlD substrate binding domain DNA_pol_A_exo1 PF01612.20 CCF39387.1 - 3.4e-42 144.1 0.3 5.2e-42 143.5 0.3 1.3 1 0 0 1 1 1 1 3'-5' exonuclease HRDC PF00570.23 CCF39387.1 - 9.5e-12 44.7 0.1 6.4e-11 42.1 0.0 2.4 1 1 1 2 2 2 1 HRDC domain Borrelia_P83 PF05262.11 CCF39387.1 - 2.2 6.7 36.9 3.5 6.0 36.9 1.3 1 0 0 1 1 1 0 Borrelia P83/100 protein 2-Hacid_dh PF00389.30 CCF39388.1 - 3.8e-18 65.5 0.0 4.5e-18 65.2 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 2-Hacid_dh_C PF02826.19 CCF39388.1 - 8.5e-14 51.3 0.0 1.8e-13 50.2 0.0 1.7 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.17 CCF39388.1 - 9.5e-05 22.9 0.0 0.00023 21.7 0.0 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent IlvN PF07991.12 CCF39388.1 - 0.00022 20.8 0.0 0.00046 19.8 0.0 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain NAD_binding_2 PF03446.15 CCF39388.1 - 0.0072 16.5 0.0 0.016 15.4 0.0 1.6 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.18 CCF39388.1 - 0.011 15.6 0.0 0.019 14.8 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain XdhC_C PF13478.6 CCF39388.1 - 0.043 14.3 0.0 0.11 13.0 0.0 1.7 1 0 0 1 1 1 0 XdhC Rossmann domain Sacchrp_dh_NADP PF03435.18 CCF39388.1 - 0.053 13.8 0.0 0.11 12.8 0.0 1.6 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Pyr_redox PF00070.27 CCF39388.1 - 0.15 12.7 0.0 0.72 10.4 0.0 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase MFS_1 PF07690.16 CCF39389.1 - 4.3e-50 170.6 54.3 1.8e-49 168.5 54.5 1.8 2 0 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 CCF39389.1 - 6.9e-20 71.0 22.4 1.2e-18 66.9 18.0 2.2 1 1 0 2 2 2 2 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 CCF39389.1 - 7.8e-16 58.0 8.4 7.8e-16 58.0 8.4 2.4 2 0 0 2 2 2 2 Sugar (and other) transporter Kinocilin PF15033.6 CCF39389.1 - 0.34 10.6 8.1 0.84 9.3 0.5 3.2 3 0 0 3 3 3 0 Kinocilin protein WD40 PF00400.32 CCF39390.1 - 2e-14 53.7 6.5 0.0083 17.0 0.1 5.6 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF39390.1 - 4.2e-07 30.2 0.3 0.0029 17.8 0.2 3.9 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CCF39390.1 - 1.8e-05 23.6 1.6 0.00015 20.5 0.3 2.5 2 1 1 3 3 3 1 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 CCF39390.1 - 0.064 12.0 0.0 6.9 5.3 0.0 2.9 2 1 1 3 3 3 0 Nup133 N terminal like HA2 PF04408.23 CCF39391.1 - 1.4e-22 80.0 0.0 1.4e-22 80.0 0.0 3.8 4 0 0 4 4 4 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 CCF39391.1 - 1.3e-19 70.3 0.0 5.4e-19 68.3 0.0 2.1 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 CCF39391.1 - 2e-14 53.8 0.0 4.6e-14 52.7 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 CCF39391.1 - 5.3e-08 32.8 0.0 9.8e-08 32.0 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF2075 PF09848.9 CCF39391.1 - 4.4e-05 22.9 0.0 9e-05 21.9 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.6 CCF39391.1 - 6.9e-05 23.1 0.1 0.00019 21.7 0.1 1.7 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 CCF39391.1 - 0.0016 17.6 0.0 0.0032 16.6 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein SRP54 PF00448.22 CCF39391.1 - 0.0023 17.6 0.1 0.0051 16.5 0.1 1.6 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain ResIII PF04851.15 CCF39391.1 - 0.0025 17.9 0.0 0.9 9.5 0.0 2.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 CCF39391.1 - 0.0027 18.1 0.0 0.0061 16.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CCF39391.1 - 0.0027 17.4 0.0 0.0067 16.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 CCF39391.1 - 0.0062 15.9 0.0 0.013 14.8 0.0 1.5 1 0 0 1 1 1 1 KaiC Flavi_DEAD PF07652.14 CCF39391.1 - 0.016 15.1 0.0 0.032 14.2 0.0 1.4 1 0 0 1 1 1 0 Flavivirus DEAD domain GAD PF02938.14 CCF39391.1 - 0.047 13.9 0.0 0.13 12.6 0.0 1.7 1 0 0 1 1 1 0 GAD domain ABC_tran PF00005.27 CCF39391.1 - 0.08 13.5 0.0 0.27 11.7 0.0 2.0 1 0 0 1 1 1 0 ABC transporter TrwB_AAD_bind PF10412.9 CCF39391.1 - 0.097 11.6 0.0 0.17 10.8 0.0 1.3 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain AAA_14 PF13173.6 CCF39391.1 - 0.098 12.7 0.2 0.56 10.3 0.2 2.2 1 1 0 1 1 1 0 AAA domain Myosin_head PF00063.21 CCF39391.1 - 0.11 10.6 0.0 0.18 10.0 0.0 1.2 1 0 0 1 1 1 0 Myosin head (motor domain) AAA_25 PF13481.6 CCF39391.1 - 0.12 11.9 0.0 0.28 10.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF4360 PF14273.6 CCF39392.1 - 1e-34 120.0 0.1 1.2e-34 119.8 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4360) Ribosomal_S9 PF00380.19 CCF39395.1 - 6.1e-28 97.8 0.1 7.3e-28 97.5 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Uds1 PF15456.6 CCF39396.1 - 4.4e-33 114.2 7.0 4.4e-33 114.2 7.0 2.3 2 0 0 2 2 2 1 Up-regulated During Septation Stathmin PF00836.19 CCF39396.1 - 0.025 14.5 0.2 0.025 14.5 0.2 2.4 2 0 0 2 2 2 0 Stathmin family Spc7 PF08317.11 CCF39396.1 - 0.15 11.0 3.9 0.24 10.2 3.9 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein GOLGA2L5 PF15070.6 CCF39396.1 - 0.37 9.4 4.5 0.084 11.5 0.7 1.7 2 0 0 2 2 2 0 Putative golgin subfamily A member 2-like protein 5 LIM_bind PF01803.16 CCF39397.1 - 2e-76 256.7 0.0 2e-76 256.7 0.0 5.0 3 1 1 4 4 4 1 LIM-domain binding protein Serinc PF03348.15 CCF39398.1 - 1e-163 545.3 5.9 1.2e-163 545.1 5.9 1.0 1 0 0 1 1 1 1 Serine incorporator (Serinc) Aldo_ket_red PF00248.21 CCF39399.1 - 1.6e-65 221.2 0.1 2.1e-65 220.9 0.1 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Cir_N PF10197.9 CCF39400.1 - 8.4e-09 35.5 3.5 8.4e-09 35.5 3.5 5.0 3 1 0 3 3 3 1 N-terminal domain of CBF1 interacting co-repressor CIR SIR2 PF02146.17 CCF39402.1 - 3.6e-29 101.9 0.2 3.6e-18 66.1 0.0 2.1 2 0 0 2 2 2 2 Sir2 family PsbI PF02532.14 CCF39403.1 - 0.071 13.1 0.2 0.094 12.7 0.2 1.2 1 0 0 1 1 1 0 Photosystem II reaction centre I protein (PSII 4.8 kDa protein) TTL PF03133.15 CCF39404.1 - 1.5e-36 126.1 0.0 6.3e-36 124.0 0.0 1.8 1 1 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 CCF39404.1 - 0.00028 20.2 0.0 0.00061 19.1 0.0 1.5 1 0 0 1 1 1 1 YheC/D like ATP-grasp Dala_Dala_lig_C PF07478.13 CCF39404.1 - 0.024 14.2 0.0 0.062 12.8 0.0 1.6 2 0 0 2 2 2 0 D-ala D-ala ligase C-terminus HAUS6_N PF14661.6 CCF39405.1 - 1.6e-56 191.5 1.1 1.6e-56 191.5 1.1 1.8 2 0 0 2 2 2 1 HAUS augmin-like complex subunit 6 N-terminus PWI PF01480.17 CCF39407.1 - 3.4e-15 56.1 0.5 8.7e-15 54.8 0.5 1.8 1 0 0 1 1 1 1 PWI domain LCD1 PF09798.9 CCF39407.1 - 3.8 5.9 6.3 4.8 5.6 6.3 1.2 1 0 0 1 1 1 0 DNA damage checkpoint protein Nuc_sug_transp PF04142.15 CCF39408.1 - 2.1e-45 155.3 0.7 2.8e-45 154.8 0.7 1.0 1 0 0 1 1 1 1 Nucleotide-sugar transporter UAA PF08449.11 CCF39408.1 - 0.00031 20.1 0.4 0.00031 20.1 0.4 1.8 2 0 0 2 2 2 1 UAA transporter family PUNUT PF16913.5 CCF39408.1 - 0.0055 16.0 1.4 0.0081 15.4 1.4 1.3 1 0 0 1 1 1 1 Purine nucleobase transmembrane transport Phage_holin_5_1 PF06946.11 CCF39408.1 - 0.016 15.6 1.3 0.04 14.3 0.1 2.2 2 0 0 2 2 2 0 Bacteriophage A118-like holin, Hol118 CRT-like PF08627.10 CCF39408.1 - 0.059 12.3 0.4 0.091 11.7 0.4 1.3 1 0 0 1 1 1 0 CRT-like, chloroquine-resistance transporter-like UPF0220 PF05255.11 CCF39408.1 - 0.14 11.7 0.1 0.14 11.7 0.1 2.5 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0220) EamA PF00892.20 CCF39408.1 - 0.59 10.3 21.2 0.096 12.9 1.6 2.7 2 1 0 2 2 2 0 EamA-like transporter family Lactamase_B PF00753.27 CCF39409.1 - 3.9e-07 30.3 0.1 5.3e-07 29.8 0.1 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_5 PF14597.6 CCF39409.1 - 0.0087 15.6 0.0 0.012 15.1 0.0 1.1 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily FYVE_2 PF02318.16 CCF39409.1 - 0.057 13.6 0.2 0.1 12.8 0.2 1.3 1 0 0 1 1 1 0 FYVE-type zinc finger AA_permease PF00324.21 CCF39410.1 - 2.6e-110 369.3 36.2 3.5e-110 368.8 36.2 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CCF39410.1 - 3.3e-20 72.3 39.3 4.4e-20 71.9 39.3 1.0 1 0 0 1 1 1 1 Amino acid permease SET PF00856.28 CCF39412.1 - 6.2e-09 36.5 0.0 7.9e-08 32.9 0.0 2.1 1 1 0 1 1 1 1 SET domain Epimerase PF01370.21 CCF39413.1 - 2.6e-21 76.2 0.0 3.7e-21 75.7 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CCF39413.1 - 1e-13 50.9 0.0 1.7e-13 50.3 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 CCF39413.1 - 1.2e-11 44.3 0.0 6.3e-11 41.9 0.0 1.9 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 CCF39413.1 - 3.7e-10 40.0 0.2 5.6e-10 39.4 0.2 1.3 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 CCF39413.1 - 2.7e-08 33.6 0.0 4.9e-08 32.7 0.0 1.5 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 CCF39413.1 - 9.2e-08 31.6 0.0 1.8e-07 30.6 0.0 1.4 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein KR PF08659.10 CCF39413.1 - 5e-06 26.5 0.1 8e-06 25.9 0.1 1.3 1 0 0 1 1 1 1 KR domain adh_short PF00106.25 CCF39413.1 - 1.1e-05 24.9 0.1 4.8e-05 22.9 0.1 1.9 2 0 0 2 2 2 1 short chain dehydrogenase F420_oxidored PF03807.17 CCF39413.1 - 0.00081 19.9 0.0 0.003 18.1 0.0 2.0 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent NmrA PF05368.13 CCF39413.1 - 0.0029 17.2 0.3 0.0082 15.7 0.3 1.8 1 1 0 1 1 1 1 NmrA-like family RmlD_sub_bind PF04321.17 CCF39413.1 - 0.012 14.7 0.1 0.047 12.8 0.0 2.0 2 0 0 2 2 2 0 RmlD substrate binding domain adh_short_C2 PF13561.6 CCF39413.1 - 0.026 14.1 0.9 0.051 13.1 0.9 1.5 1 1 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase Glyco_trans_4_4 PF13579.6 CCF39413.1 - 0.053 14.0 1.5 1 9.8 0.0 2.2 2 0 0 2 2 2 0 Glycosyl transferase 4-like domain SpoU_sub_bind PF08032.12 CCF39413.1 - 0.13 12.5 0.1 0.57 10.5 0.0 2.0 2 0 0 2 2 2 0 RNA 2'-O ribose methyltransferase substrate binding Flg_hook PF02120.16 CCF39413.1 - 0.13 12.1 0.0 0.42 10.5 0.0 1.8 2 0 0 2 2 2 0 Flagellar hook-length control protein FliK Molybdopterin_N PF18364.1 CCF39414.1 - 0.07 13.2 0.3 6.8 6.8 0.0 2.5 1 1 1 2 2 2 0 Molybdopterin oxidoreductase N-terminal domain Acetyltransf_1 PF00583.25 CCF39416.1 - 2.4e-08 34.2 0.0 3.2e-08 33.8 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CCF39416.1 - 1.2e-06 28.5 0.0 1.8e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CCF39416.1 - 1.5e-05 25.3 0.0 2.3e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CCF39416.1 - 0.0011 18.9 0.0 0.003 17.5 0.0 1.7 2 0 0 2 2 2 1 FR47-like protein HsbA PF12296.8 CCF39417.1 - 1.1e-18 67.8 6.9 1.5e-18 67.4 6.9 1.2 1 0 0 1 1 1 1 Hydrophobic surface binding protein A zf-C2H2 PF00096.26 CCF39418.1 - 0.00024 21.4 12.8 0.0063 16.9 2.1 2.5 2 0 0 2 2 2 2 Zinc finger, C2H2 type Integrin_B_tail PF07965.12 CCF39418.1 - 0.026 15.0 0.8 0.06 13.8 0.3 1.7 1 1 1 2 2 2 0 Integrin beta tail domain zf-H2C2_2 PF13465.6 CCF39418.1 - 0.031 14.7 2.3 0.031 14.7 2.3 2.8 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2H2_4 PF13894.6 CCF39418.1 - 0.033 15.0 10.4 0.21 12.5 1.5 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger zf-met PF12874.7 CCF39418.1 - 0.17 12.3 7.7 0.42 11.1 0.4 2.5 2 0 0 2 2 2 0 Zinc-finger of C2H2 type FOXP-CC PF16159.5 CCF39418.1 - 0.27 11.9 3.2 0.26 12.0 0.5 2.0 1 1 1 2 2 2 0 FOXP coiled-coil domain ATP_bind_3 PF01171.20 CCF39419.1 - 3e-41 141.2 0.1 1.1e-28 100.2 0.0 2.4 2 0 0 2 2 2 2 PP-loop family Asn_synthase PF00733.21 CCF39419.1 - 0.024 14.3 0.0 0.074 12.7 0.0 1.8 2 0 0 2 2 2 0 Asparagine synthase TPPII_N PF12583.8 CCF39419.1 - 6.3 7.4 14.0 0.74 10.4 4.8 2.3 2 0 0 2 2 2 0 Tripeptidyl peptidase II N terminal Mito_carr PF00153.27 CCF39420.1 - 2.9e-46 155.3 7.5 2.8e-19 68.8 0.3 4.1 3 1 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 CCF39420.1 - 0.0097 15.1 1.8 0.17 11.0 0.2 2.3 2 0 0 2 2 2 2 Gammaproteobacterial serine protease VWA_2 PF13519.6 CCF39421.1 - 3.4e-08 34.1 0.0 4.8e-08 33.6 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 CCF39421.1 - 2.6e-06 27.8 0.0 3.9e-06 27.2 0.0 1.3 1 1 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 CCF39421.1 - 0.11 12.5 0.0 6.7 6.6 0.0 2.1 2 0 0 2 2 2 0 von Willebrand factor type A domain SUV3_C PF12513.8 CCF39422.1 - 3.4e-17 62.1 0.2 3.4e-17 62.1 0.2 2.0 2 0 0 2 2 2 1 Mitochondrial degradasome RNA helicase subunit C terminal Suv3_C_1 PF18147.1 CCF39422.1 - 1.4e-10 40.8 1.1 3.5e-10 39.6 0.1 2.2 2 0 0 2 2 2 1 Suv3 C-terminal domain 1 DUF4093 PF13331.6 CCF39422.1 - 0.11 12.9 0.0 0.2 12.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4093) Peptidase_C12 PF01088.21 CCF39423.1 - 1.5e-55 188.2 0.0 1.8e-55 188.0 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 DAHP_synth_1 PF00793.20 CCF39425.1 - 3e-19 68.9 0.0 3.7e-19 68.7 0.0 1.1 1 0 0 1 1 1 1 DAHP synthetase I family Far-17a_AIG1 PF04750.14 CCF39426.1 - 1.6e-45 154.9 10.2 1.9e-45 154.7 10.2 1.0 1 0 0 1 1 1 1 FAR-17a/AIG1-like protein DUF3185 PF11381.8 CCF39426.1 - 0.31 11.1 3.6 0.24 11.4 1.8 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3185) WD40 PF00400.32 CCF39427.1 - 4e-11 43.3 0.1 0.00037 21.2 0.0 5.1 5 1 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF39427.1 - 0.0002 21.6 0.0 0.04 14.2 0.0 3.1 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CCF39427.1 - 0.0084 15.1 0.4 0.14 11.1 0.1 2.3 1 1 1 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF5643 PF18705.1 CCF39427.1 - 0.033 14.1 0.1 0.12 12.3 0.0 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5643) She2p PF11435.8 CCF39427.1 - 0.17 11.6 0.3 3.6 7.2 0.0 2.2 2 0 0 2 2 2 0 RNA binding protein She2p Cyt-b5 PF00173.28 CCF39431.1 - 8.9e-11 41.8 0.1 1e-10 41.6 0.1 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain TPR_12 PF13424.6 CCF39432.1 - 2.7e-10 40.4 0.5 0.005 17.1 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 CCF39432.1 - 7.3e-05 22.6 1.0 0.15 12.3 0.0 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 CCF39432.1 - 0.0075 16.2 0.1 6.1 7.1 0.0 4.3 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_1 PF00515.28 CCF39432.1 - 0.0096 15.7 1.3 12 5.9 0.2 4.0 4 1 0 4 4 4 1 Tetratricopeptide repeat Gloverin PF10793.9 CCF39432.1 - 0.028 14.3 0.1 0.051 13.4 0.1 1.4 1 0 0 1 1 1 0 Gloverin-like protein TPR_8 PF13181.6 CCF39432.1 - 0.051 13.8 0.4 26 5.3 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat RPN7 PF10602.9 CCF39432.1 - 0.07 12.8 0.3 3.5 7.3 0.0 2.5 3 0 0 3 3 3 0 26S proteasome subunit RPN7 TPR_10 PF13374.6 CCF39432.1 - 0.08 12.8 0.8 19 5.3 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_21 PF09976.9 CCF39432.1 - 0.15 11.8 0.7 0.95 9.1 0.0 2.4 3 0 0 3 3 3 0 Tetratricopeptide repeat-like domain GH43_C2 PF17851.1 CCF39433.1 - 2.5e-14 53.5 0.0 2.7e-14 53.4 0.0 1.0 1 0 0 1 1 1 1 Beta xylosidase C-terminal Concanavalin A-like domain ADH_N PF08240.12 CCF39434.1 - 3.3e-22 78.4 3.4 5.3e-22 77.8 3.4 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCF39434.1 - 2e-16 60.2 0.0 5.4e-16 58.8 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCF39434.1 - 5.9e-05 24.1 0.0 0.00011 23.2 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase adh_short PF00106.25 CCF39434.1 - 0.0038 16.7 0.1 0.14 11.6 0.0 2.8 2 1 1 3 3 3 1 short chain dehydrogenase 2-Hacid_dh_C PF02826.19 CCF39434.1 - 0.016 14.6 0.0 0.027 13.8 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain XdhC_C PF13478.6 CCF39434.1 - 0.072 13.6 0.0 0.18 12.3 0.0 1.7 2 0 0 2 2 2 0 XdhC Rossmann domain AlaDh_PNT_C PF01262.21 CCF39434.1 - 0.091 12.0 0.1 0.28 10.5 0.1 1.8 1 1 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain PDEase_I PF00233.19 CCF39435.1 - 2.6e-65 220.5 0.1 3.9e-65 219.9 0.1 1.3 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase MOR2-PAG1_N PF14222.6 CCF39436.1 - 3.2e-223 742.7 0.0 4.1e-223 742.3 0.0 1.1 1 0 0 1 1 1 1 Cell morphogenesis N-terminal Bgal_small_N PF02929.17 CCF39437.1 - 1.5e-58 198.3 0.1 2e-58 197.9 0.1 1.2 1 0 0 1 1 1 1 Beta galactosidase small chain Mito_carr PF00153.27 CCF39439.1 - 4.3e-37 125.9 1.9 2.1e-13 50.0 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein RibD_C PF01872.17 CCF39440.1 - 2e-35 122.4 0.0 2.4e-35 122.2 0.0 1.0 1 0 0 1 1 1 1 RibD C-terminal domain Transp_cyt_pur PF02133.15 CCF39441.1 - 7e-19 67.9 28.2 3.8e-16 58.9 28.2 2.8 1 1 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin DUF2428 PF10350.9 CCF39443.1 - 7.7e-61 205.8 0.1 1.5e-60 204.8 0.1 1.5 1 0 0 1 1 1 1 Putative death-receptor fusion protein (DUF2428) HEAT PF02985.22 CCF39443.1 - 1.7e-06 27.8 0.2 0.025 14.8 0.0 4.3 3 0 0 3 3 3 2 HEAT repeat HEAT_2 PF13646.6 CCF39443.1 - 0.00084 19.7 2.9 0.64 10.5 0.1 4.3 5 0 0 5 5 5 2 HEAT repeats HEAT_EZ PF13513.6 CCF39443.1 - 0.16 12.5 1.7 13 6.5 0.2 3.2 3 0 0 3 3 3 0 HEAT-like repeat Response_reg PF00072.24 CCF39444.1 - 1.1e-27 96.5 0.6 1.8e-27 95.7 0.6 1.4 1 0 0 1 1 1 1 Response regulator receiver domain HATPase_c PF02518.26 CCF39444.1 - 2.1e-26 92.6 0.1 1.4e-23 83.5 0.6 3.4 3 1 0 3 3 3 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CCF39444.1 - 3e-14 52.8 0.0 6.2e-14 51.8 0.0 1.6 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 CCF39444.1 - 0.0031 17.9 0.0 0.048 14.0 0.0 2.4 2 0 0 2 2 2 1 HAMP domain Methyltransf_23 PF13489.6 CCF39446.1 - 6.6e-09 35.8 0.0 9.2e-09 35.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF39446.1 - 7.5e-07 29.7 0.0 1.6e-06 28.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF39446.1 - 5.3e-06 27.0 0.0 1.5e-05 25.6 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF39446.1 - 1.9e-05 25.3 0.0 3.9e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF39446.1 - 8e-05 22.5 0.0 0.00012 21.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCF39446.1 - 0.00062 19.2 0.0 0.0011 18.3 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_8 PF05148.15 CCF39446.1 - 0.14 12.0 0.0 0.23 11.3 0.0 1.5 1 1 0 1 1 1 0 Hypothetical methyltransferase WH2 PF02205.20 CCF39448.1 - 1.8e-09 37.1 3.9 2.5e-08 33.5 0.9 3.0 3 0 0 3 3 3 2 WH2 motif Condensation PF00668.20 CCF39449.1 - 1.6e-21 76.5 0.0 1.8e-21 76.3 0.0 1.0 1 0 0 1 1 1 1 Condensation domain Zn_clus PF00172.18 CCF39450.1 - 2.3e-08 34.0 7.2 4.2e-08 33.2 7.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_hydro_3_C PF01915.22 CCF39452.1 - 1.2e-56 191.9 0.0 3e-56 190.6 0.0 1.6 2 0 0 2 2 2 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 CCF39452.1 - 1.1e-52 179.4 0.0 1.7e-52 178.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 CCF39452.1 - 1.5e-24 85.9 0.5 3.7e-24 84.6 0.5 1.7 1 0 0 1 1 1 1 Fibronectin type III-like domain PA14 PF07691.12 CCF39452.1 - 1.7e-05 24.6 0.0 3.6e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 PA14 domain Mx_ML PF17536.2 CCF39452.1 - 0.083 12.6 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 Matrix and Matrix long proteins N-terminal CoaE PF01121.20 CCF39455.1 - 5.7e-42 143.4 0.0 2.2e-41 141.5 0.0 1.8 1 1 0 1 1 1 1 Dephospho-CoA kinase AAA_18 PF13238.6 CCF39455.1 - 0.013 16.0 0.1 0.37 11.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain Lipase_3 PF01764.25 CCF39456.1 - 4.1e-06 26.7 0.0 1e-05 25.4 0.0 1.6 1 0 0 1 1 1 1 Lipase (class 3) UPF0227 PF05728.12 CCF39456.1 - 0.0013 18.7 0.0 0.0021 18.0 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0227) Abhydrolase_1 PF00561.20 CCF39456.1 - 0.038 13.6 0.0 0.084 12.5 0.0 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CCF39456.1 - 0.044 13.0 0.0 0.08 12.2 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 YL1 PF05764.13 CCF39457.1 - 8.2e-72 242.2 29.6 8.2e-72 242.2 29.6 2.3 3 0 0 3 3 3 2 YL1 nuclear protein DUF2849 PF11011.8 CCF39457.1 - 0.06 14.0 0.1 0.06 14.0 0.1 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF2849) SDA1 PF05285.12 CCF39457.1 - 0.06 12.8 37.5 0.02 14.3 26.1 2.3 2 1 0 2 2 2 0 SDA1 Sugar_tr PF00083.24 CCF39458.1 - 1.2e-70 238.6 13.4 1.5e-70 238.3 13.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF39458.1 - 7.7e-34 117.1 21.2 9.7e-34 116.8 21.2 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 CCF39458.1 - 6.5e-06 24.8 2.2 6.5e-06 24.8 2.2 1.7 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.20 CCF39458.1 - 1.4e-05 23.6 9.6 6.4e-05 21.4 2.2 2.4 1 1 1 2 2 2 2 Organic Anion Transporter Polypeptide (OATP) family RseC_MucC PF04246.12 CCF39458.1 - 2 8.4 4.5 0.45 10.5 0.8 1.8 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC Glyco_hydro_2_N PF02837.18 CCF39459.1 - 2.4e-05 24.3 0.0 3.5e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Rgp1 PF08737.10 CCF39460.1 - 1.5e-159 531.7 0.0 3.1e-159 530.6 0.0 1.5 1 0 0 1 1 1 1 Rgp1 Arrestin_N PF00339.29 CCF39460.1 - 0.00029 20.9 0.1 0.0011 19.0 0.0 1.9 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain GlcNAc-1_reg PF18440.1 CCF39461.1 - 0.0021 18.3 0.1 0.0085 16.3 0.0 1.9 2 0 0 2 2 2 1 Putative GlcNAc-1 phosphotransferase regulatory domain DNA_pol_phi PF04931.13 CCF39462.1 - 8.5e-53 179.6 0.3 1.8e-52 178.5 0.0 1.6 2 0 0 2 2 2 1 DNA polymerase phi Mannosyl_trans3 PF11051.8 CCF39463.1 - 1.8e-47 162.0 0.0 2.5e-28 99.2 0.0 2.2 1 1 1 2 2 2 2 Mannosyltransferase putative DIOX_N PF14226.6 CCF39464.1 - 6.5e-29 101.1 0.0 9.8e-29 100.5 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 CCF39464.1 - 2.1e-17 63.5 0.0 3.6e-17 62.7 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily MFS_1 PF07690.16 CCF39465.1 - 3.2e-26 92.1 50.7 2.6e-22 79.2 31.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF39465.1 - 0.00056 18.9 34.0 0.0015 17.5 14.7 2.4 2 0 0 2 2 2 2 Sugar (and other) transporter UL41A PF17591.2 CCF39465.1 - 0.93 9.6 5.7 5.2 7.2 0.2 3.3 3 0 0 3 3 3 0 Herpesvirus UL41A FAD_binding_3 PF01494.19 CCF39466.1 - 3.1e-20 72.7 0.0 7.5e-20 71.5 0.0 1.7 1 1 0 1 1 1 1 FAD binding domain NAD_binding_9 PF13454.6 CCF39466.1 - 7.4e-05 22.8 0.0 0.00019 21.5 0.0 1.7 2 0 0 2 2 2 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 CCF39466.1 - 0.00014 22.0 0.2 0.00069 19.8 0.3 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Trp_halogenase PF04820.14 CCF39466.1 - 0.0029 16.5 0.2 0.21 10.4 0.3 2.2 2 0 0 2 2 2 1 Tryptophan halogenase Pyr_redox_2 PF07992.14 CCF39466.1 - 0.0067 15.7 0.2 0.048 12.9 0.1 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCF39466.1 - 0.0069 16.0 0.9 0.013 15.1 0.9 1.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 CCF39466.1 - 0.0093 15.1 0.0 3.8 6.4 0.0 2.1 2 0 0 2 2 2 2 Lycopene cyclase protein Pyr_redox PF00070.27 CCF39466.1 - 0.03 14.9 0.2 0.067 13.8 0.2 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DUF924 PF06041.11 CCF39466.1 - 0.091 12.9 0.0 0.15 12.2 0.0 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF924) SE PF08491.10 CCF39466.1 - 0.25 10.4 0.0 3.7 6.5 0.0 2.0 2 0 0 2 2 2 0 Squalene epoxidase HI0933_like PF03486.14 CCF39466.1 - 0.44 9.2 0.9 0.65 8.6 0.9 1.2 1 0 0 1 1 1 0 HI0933-like protein ketoacyl-synt PF00109.26 CCF39467.1 - 1.4e-70 237.8 0.1 3.2e-70 236.6 0.1 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 CCF39467.1 - 8.7e-32 109.6 0.0 1.9e-31 108.5 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Acyl_transf_1 PF00698.21 CCF39467.1 - 1.8e-26 93.4 0.0 4.4e-26 92.1 0.0 1.6 2 0 0 2 2 2 1 Acyl transferase domain SAT PF16073.5 CCF39467.1 - 4e-15 56.2 4.7 2.4e-11 43.8 0.1 3.7 3 1 0 3 3 3 2 Starter unit:ACP transacylase in aflatoxin biosynthesis Thiolase_N PF00108.23 CCF39467.1 - 2.3e-08 33.8 0.6 6.1e-08 32.3 0.2 1.9 2 0 0 2 2 2 1 Thiolase, N-terminal domain KAsynt_C_assoc PF16197.5 CCF39467.1 - 0.0041 17.6 0.0 0.01 16.3 0.0 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension ACP_syn_III PF08545.10 CCF39467.1 - 0.1 12.5 2.4 0.65 9.9 2.4 2.4 1 1 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Cep57_CLD PF14073.6 CCF39469.1 - 5.1e-05 23.4 8.5 5.1e-05 23.4 8.5 3.9 1 1 1 3 3 1 1 Centrosome localisation domain of Cep57 Lebercilin PF15619.6 CCF39469.1 - 0.0012 18.6 14.1 0.0012 18.6 14.1 4.8 1 1 2 4 4 3 2 Ciliary protein causing Leber congenital amaurosis disease DUF1664 PF07889.12 CCF39469.1 - 0.014 15.4 35.9 0.05 13.6 3.2 6.5 2 2 4 7 7 7 0 Protein of unknown function (DUF1664) SlyX PF04102.12 CCF39469.1 - 0.065 13.9 0.3 0.065 13.9 0.3 8.1 4 2 3 8 8 8 0 SlyX Flagellin_C PF00700.21 CCF39469.1 - 0.1 12.9 1.6 0.8 10.1 0.2 3.0 2 0 0 2 2 2 0 Bacterial flagellin C-terminal helical region PLN_propep PF16485.5 CCF39469.1 - 0.1 12.3 0.3 0.25 11.1 0.3 1.7 1 0 0 1 1 1 0 Protealysin propeptide FPP PF05911.11 CCF39469.1 - 0.32 9.1 66.0 0.36 9.0 12.4 3.4 1 1 2 3 3 3 0 Filament-like plant protein, long coiled-coil TACC_C PF05010.14 CCF39469.1 - 0.54 10.0 73.0 0.084 12.7 6.8 5.7 1 1 3 5 5 5 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal MKRN1_C PF15815.5 CCF39469.1 - 0.82 10.1 5.8 2.1 8.8 0.4 3.5 3 0 0 3 3 3 0 E3 ubiquitin-protein ligase makorin-1, C-terminal Spc7 PF08317.11 CCF39469.1 - 2.7 6.8 77.8 1.8 7.4 15.3 4.9 1 1 4 5 5 5 0 Spc7 kinetochore protein ADIP PF11559.8 CCF39469.1 - 5.3 7.1 66.0 0.027 14.6 5.0 6.5 1 1 6 7 7 7 0 Afadin- and alpha -actinin-Binding Fez1 PF06818.15 CCF39469.1 - 5.5 7.4 79.8 2.4 8.5 15.0 4.4 1 1 3 4 4 4 0 Fez1 Fib_alpha PF08702.10 CCF39469.1 - 6.3 7.0 43.5 0.029 14.6 6.3 5.7 2 2 1 5 5 5 0 Fibrinogen alpha/beta chain family Clathrin PF00637.20 CCF39470.1 - 7e-183 599.8 27.9 1.5e-33 115.7 0.9 6.1 6 0 0 6 6 6 6 Region in Clathrin and VPS TPR_14 PF13428.6 CCF39470.1 - 3.8e-07 30.4 0.1 2.7 9.1 0.0 6.6 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_7 PF13176.6 CCF39470.1 - 2.5e-05 24.0 0.9 9.7 6.5 0.0 5.9 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.6 CCF39470.1 - 0.00015 21.7 0.6 0.13 12.5 0.1 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat Vps39_1 PF10366.9 CCF39470.1 - 0.0024 18.1 3.3 1.7 8.9 0.0 5.6 5 1 1 6 6 6 1 Vacuolar sorting protein 39 domain 1 TPR_12 PF13424.6 CCF39470.1 - 0.0068 16.7 0.3 9.4 6.6 0.0 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 CCF39470.1 - 0.016 15.7 0.0 19 5.9 0.1 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 CCF39470.1 - 0.026 14.6 1.3 1.2 9.4 0.1 4.2 4 0 0 4 4 2 0 Tetratricopeptide repeat 6PF2K PF01591.18 CCF39470.1 - 0.056 12.7 1.2 0.27 10.5 0.2 2.4 2 0 0 2 2 2 0 6-phosphofructo-2-kinase TPR_10 PF13374.6 CCF39470.1 - 0.099 12.5 0.2 15 5.7 0.0 4.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 CCF39470.1 - 0.28 11.1 3.9 1.1 9.2 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat HA2 PF04408.23 CCF39471.1 - 1.2e-17 64.2 0.3 3.5e-17 62.6 0.0 2.0 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 CCF39471.1 - 5.9e-15 55.4 0.0 1.3e-14 54.3 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 CCF39471.1 - 1.2e-14 54.6 0.0 3.1e-14 53.3 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_30 PF13604.6 CCF39471.1 - 5.3e-05 23.0 1.3 8.5e-05 22.3 0.1 1.8 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 CCF39471.1 - 0.00019 21.7 0.1 0.00064 20.0 0.1 1.9 1 1 0 1 1 1 1 AAA domain DEAD PF00270.29 CCF39471.1 - 0.0012 18.7 0.7 0.0045 16.8 0.7 1.9 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_19 PF13245.6 CCF39471.1 - 0.0012 19.2 0.1 0.0037 17.6 0.1 1.8 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 CCF39471.1 - 0.015 14.4 0.1 0.04 13.0 0.0 1.7 2 0 0 2 2 2 0 Type II/IV secretion system protein cobW PF02492.19 CCF39471.1 - 0.019 14.5 0.3 1.2 8.7 0.1 2.6 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain AAA_23 PF13476.6 CCF39471.1 - 0.023 15.2 0.4 0.054 14.0 0.0 1.8 2 1 0 2 2 2 0 AAA domain AAA_33 PF13671.6 CCF39471.1 - 0.092 12.9 0.6 0.23 11.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 CCF39471.1 - 0.11 12.0 0.3 0.42 10.1 0.0 2.1 3 0 0 3 3 3 0 P-loop containing dynein motor region ABC_tran PF00005.27 CCF39471.1 - 0.16 12.5 0.6 0.93 10.0 0.2 2.2 2 1 0 2 2 2 0 ABC transporter FBPase_2 PF06874.11 CCF39471.1 - 0.26 9.6 1.0 0.55 8.5 0.1 1.8 2 0 0 2 2 2 0 Firmicute fructose-1,6-bisphosphatase CUE PF02845.16 CCF39472.1 - 2.6e-12 46.2 0.0 4e-12 45.6 0.0 1.3 1 0 0 1 1 1 1 CUE domain DUF3621 PF12285.8 CCF39472.1 - 0.23 11.8 2.8 0.57 10.6 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3621) DNA_primase_lrg PF04104.14 CCF39473.1 - 5e-70 235.9 0.0 8e-70 235.3 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit PRR20 PF15708.5 CCF39474.1 - 2.4 8.0 5.4 2.6 7.9 5.4 1.0 1 0 0 1 1 1 0 Proline-rich protein family 20 Ank_2 PF12796.7 CCF39475.1 - 2.1e-05 25.0 0.0 0.00059 20.4 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 CCF39475.1 - 0.00053 20.3 0.1 4.9 7.8 0.1 3.7 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 CCF39475.1 - 0.0054 17.3 0.0 0.078 13.6 0.0 2.8 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCF39475.1 - 0.032 14.7 0.0 39 5.3 0.0 3.5 3 0 0 3 3 3 0 Ankyrin repeat TetR_C_11 PF16859.5 CCF39475.1 - 0.038 14.3 0.2 0.083 13.2 0.2 1.6 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Aspzincin_M35 PF14521.6 CCF39476.1 - 7.3e-35 120.6 4.0 7.3e-35 120.6 4.0 1.4 1 1 1 2 2 2 1 Lysine-specific metallo-endopeptidase Peptidase_M35 PF02102.15 CCF39476.1 - 1.4e-19 70.2 10.9 1.8e-19 69.8 10.9 1.0 1 0 0 1 1 1 1 Deuterolysin metalloprotease (M35) family HRXXH PF13933.6 CCF39476.1 - 0.0022 17.6 1.6 0.0054 16.3 0.4 1.9 2 0 0 2 2 2 1 Putative peptidase family Inhibitor_I67 PF11405.8 CCF39476.1 - 2.9 8.2 6.9 0.39 11.0 2.0 2.0 2 0 0 2 2 2 0 Bromelain inhibitor VI IL3Ra_N PF18611.1 CCF39477.1 - 0.018 15.0 0.7 0.029 14.4 0.7 1.3 1 0 0 1 1 1 0 IL-3 receptor alpha chain N-terminal domain DUF3586 PF12131.8 CCF39477.1 - 0.05 13.8 1.5 0.075 13.3 1.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3586) Inhibitor_I36 PF03995.13 CCF39477.1 - 0.18 11.7 5.5 0.085 12.8 3.4 1.7 2 1 0 2 2 2 0 Peptidase inhibitor family I36 Cnd2 PF05786.14 CCF39479.1 - 0.0018 17.0 2.1 0.0028 16.4 2.1 1.3 1 0 0 1 1 1 1 Condensin complex subunit 2 HEAT PF02985.22 CCF39479.1 - 0.018 15.3 0.0 0.2 12.0 0.0 3.0 1 0 0 1 1 1 0 HEAT repeat CNDH2_C PF16858.5 CCF39479.1 - 0.057 13.3 4.4 5.3 6.8 4.5 2.2 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term RTP1_C1 PF10363.9 CCF39479.1 - 0.2 11.8 3.9 2 8.6 0.2 3.9 5 1 1 6 6 6 0 Required for nuclear transport of RNA pol II C-terminus 1 BUD22 PF09073.10 CCF39479.1 - 0.32 10.3 12.3 0.7 9.2 12.3 1.6 1 0 0 1 1 1 0 BUD22 Nop14 PF04147.12 CCF39479.1 - 0.58 8.3 13.9 0.92 7.6 13.9 1.2 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 CCF39479.1 - 0.75 9.2 13.0 1.2 8.5 13.0 1.3 1 0 0 1 1 1 0 SDA1 Arm PF00514.23 CCF39479.1 - 1.1 9.4 7.1 2.1 8.5 0.3 3.9 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat DnaJ PF00226.31 CCF39480.1 - 3.8e-13 49.3 4.0 9.9e-13 48.0 0.4 2.8 3 0 0 3 3 3 1 DnaJ domain Herpes_env PF01673.18 CCF39480.1 - 0.52 9.2 3.5 0.63 8.9 3.5 1.1 1 0 0 1 1 1 0 Herpesvirus putative major envelope glycoprotein ALMT PF11744.8 CCF39480.1 - 5.4 5.7 7.2 7 5.4 7.2 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DEAD PF00270.29 CCF39481.1 - 1.3e-12 47.9 0.0 1.6e-12 47.5 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Glyco_transf_20 PF00982.21 CCF39482.1 - 2.7e-165 550.6 0.0 3.8e-165 550.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 CCF39482.1 - 8.2e-46 156.0 0.0 1.5e-45 155.2 0.0 1.4 1 0 0 1 1 1 1 Trehalose-phosphatase Hydrolase_3 PF08282.12 CCF39482.1 - 0.0021 17.9 0.0 0.04 13.7 0.0 2.3 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase ParB_C PF18064.1 CCF39482.1 - 0.016 15.4 0.1 0.044 13.9 0.1 1.7 1 0 0 1 1 1 0 Centromere-binding protein ParB C-terminal Glyco_transf_5 PF08323.11 CCF39482.1 - 0.08 12.6 0.4 0.15 11.7 0.4 1.4 1 0 0 1 1 1 0 Starch synthase catalytic domain PNP_UDP_1 PF01048.20 CCF39483.1 - 5.8e-40 137.0 0.4 6.8e-40 136.8 0.4 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily tRNA-synt_1b PF00579.25 CCF39484.1 - 9.8e-59 199.1 0.0 1.3e-58 198.7 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) Atx10homo_assoc PF09759.9 CCF39485.1 - 3.1e-12 46.4 0.0 7.5e-12 45.1 0.0 1.6 1 0 0 1 1 1 1 Spinocerebellar ataxia type 10 protein domain Clr5 PF14420.6 CCF39486.1 - 7.5e-19 67.7 3.1 7.5e-19 67.7 3.1 1.6 2 0 0 2 2 2 1 Clr5 domain PH PF00169.29 CCF39487.1 - 0.0013 19.2 0.0 0.0025 18.3 0.0 1.5 1 0 0 1 1 1 1 PH domain Apolipoprotein PF01442.18 CCF39487.1 - 0.038 13.9 0.1 0.076 12.9 0.1 1.5 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain eRF1_3 PF03465.15 CCF39487.1 - 0.1 13.1 0.1 0.46 11.0 0.0 2.1 2 0 0 2 2 2 0 eRF1 domain 3 Dioxygenase_C PF00775.21 CCF39489.1 - 4.5e-46 156.6 0.0 7e-46 156.0 0.0 1.2 1 0 0 1 1 1 1 Dioxygenase Dioxygenase_N PF04444.14 CCF39489.1 - 3.8e-30 103.5 0.0 8e-30 102.5 0.0 1.6 1 0 0 1 1 1 1 Catechol dioxygenase N terminus CarboxypepD_reg PF13620.6 CCF39489.1 - 0.0079 16.4 0.0 0.022 15.0 0.0 1.8 1 1 0 1 1 1 1 Carboxypeptidase regulatory-like domain Big_1 PF02369.16 CCF39489.1 - 0.013 15.5 0.0 0.027 14.5 0.0 1.5 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 1) DUF824 PF05688.11 CCF39489.1 - 0.041 13.7 0.0 0.076 12.9 0.0 1.4 1 0 0 1 1 1 0 Salmonella repeat of unknown function (DUF824) SpaA PF17802.1 CCF39489.1 - 0.077 13.3 0.0 0.24 11.8 0.0 1.7 2 0 0 2 2 2 0 Prealbumin-like fold domain AP_endonuc_2 PF01261.24 CCF39490.1 - 1.7e-34 119.1 0.0 2.7e-34 118.4 0.0 1.3 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel Inositol_P PF00459.25 CCF39491.1 - 4.3e-80 269.1 0.0 4.8e-80 269.0 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family Fe-ADH PF00465.19 CCF39492.1 - 2.4e-14 52.9 0.0 2.7e-14 52.8 0.0 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase DUF2703 PF10865.8 CCF39492.1 - 0.12 12.5 0.0 0.16 12.2 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2703) RNase_H PF00075.24 CCF39493.1 - 8.5e-22 77.9 0.0 1.2e-21 77.4 0.0 1.2 1 0 0 1 1 1 1 RNase H RVT_3 PF13456.6 CCF39493.1 - 0.11 12.3 0.1 2.6 7.9 0.1 2.2 1 1 0 1 1 1 0 Reverse transcriptase-like Ribosomal_L1 PF00687.21 CCF39494.1 - 9.8e-46 156.1 0.1 1.1e-45 155.9 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family p450 PF00067.22 CCF39496.1 - 1.6e-47 162.4 0.0 2e-47 162.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 AAA_12 PF13087.6 CCF39497.1 - 9.3e-63 211.4 0.0 1.5e-62 210.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 CCF39497.1 - 6.7e-51 173.6 1.0 1.1e-50 172.9 1.0 1.3 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 CCF39497.1 - 1.4e-06 28.2 0.0 0.022 14.5 0.0 3.2 2 1 1 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_19 PF13245.6 CCF39497.1 - 0.0015 18.9 0.0 0.0051 17.2 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CCF39497.1 - 0.011 15.4 0.1 0.14 11.9 0.0 2.3 2 1 0 2 2 2 0 AAA domain UvrD-helicase PF00580.21 CCF39497.1 - 0.034 13.7 0.2 1.3 8.5 0.5 2.1 1 1 1 2 2 2 0 UvrD/REP helicase N-terminal domain tRNA-synt_1d PF00750.19 CCF39500.1 - 5.6e-102 341.2 2.8 8e-102 340.7 2.8 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 CCF39500.1 - 3.1e-30 104.8 0.1 8.4e-30 103.4 0.1 1.8 1 0 0 1 1 1 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.16 CCF39500.1 - 0.0064 17.1 0.0 0.023 15.3 0.0 2.0 2 0 0 2 2 2 1 Arginyl tRNA synthetase N terminal domain DHHC PF01529.20 CCF39501.1 - 0.017 15.2 5.6 12 6.0 1.6 3.4 2 1 1 3 3 3 0 DHHC palmitoyltransferase Metallophos PF00149.28 CCF39502.1 - 2.2e-32 113.2 0.1 2.7e-22 80.3 0.0 2.2 1 1 0 2 2 2 2 Calcineurin-like phosphoesterase STPPase_N PF16891.5 CCF39502.1 - 0.034 14.6 0.1 0.086 13.3 0.1 1.7 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain TPR_MLP1_2 PF07926.12 CCF39503.1 - 0.19 11.8 5.5 2.2 8.3 0.1 2.7 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein Pentapeptide_2 PF01469.18 CCF39503.1 - 0.94 9.4 6.9 1.9 8.4 6.9 1.4 1 0 0 1 1 1 0 Pentapeptide repeats (8 copies) AFG1_ATPase PF03969.16 CCF39504.1 - 3.8e-34 118.2 0.0 5.3e-34 117.7 0.0 1.2 1 0 0 1 1 1 1 AFG1-like ATPase AAA_16 PF13191.6 CCF39504.1 - 0.0021 18.5 0.0 0.019 15.3 0.0 2.2 1 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 CCF39504.1 - 0.0067 16.7 0.0 0.02 15.2 0.0 1.8 2 1 1 3 3 3 1 AAA domain AAA_5 PF07728.14 CCF39504.1 - 0.014 15.4 0.0 0.024 14.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 CCF39504.1 - 0.025 14.6 0.0 0.041 13.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 CCF39504.1 - 0.028 14.8 0.0 0.06 13.7 0.0 1.6 1 0 0 1 1 1 0 RNA helicase TsaE PF02367.17 CCF39504.1 - 0.041 13.9 0.0 0.065 13.2 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 CCF39504.1 - 0.05 13.5 0.0 0.092 12.7 0.0 1.4 1 0 0 1 1 1 0 NACHT domain Glyco_hydro_92 PF07971.12 CCF39505.1 - 9.5e-118 394.0 0.4 1.4e-117 393.5 0.4 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 CCF39505.1 - 1.3e-48 165.9 1.6 2.1e-48 165.3 1.6 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain Flavoprotein PF02441.19 CCF39506.1 - 2.5e-18 66.3 0.0 4.1e-18 65.6 0.0 1.3 1 0 0 1 1 1 1 Flavoprotein Ank_4 PF13637.6 CCF39506.1 - 0.1 13.2 0.0 1.3 9.7 0.0 2.8 3 1 0 3 3 3 0 Ankyrin repeats (many copies) SDF PF00375.18 CCF39507.1 - 1.1e-62 212.3 20.9 1.2e-62 212.1 20.9 1.0 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family Thioredoxin_5 PF13743.6 CCF39513.1 - 0.019 14.7 0.0 0.055 13.2 0.0 1.7 1 0 0 1 1 1 0 Thioredoxin SLATT_6 PF18169.1 CCF39513.1 - 0.038 13.6 0.4 0.071 12.7 0.0 1.6 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 6 YlaH PF14036.6 CCF39514.1 - 0.71 10.2 11.2 0.1 12.9 5.9 2.3 2 0 0 2 2 2 0 YlaH-like protein Serpentine_r_xa PF03383.15 CCF39514.1 - 0.99 9.4 7.0 0.31 11.0 3.4 2.1 1 1 1 2 2 2 0 Caenorhabditis serpentine receptor-like protein, class xa Fungal_trans_2 PF11951.8 CCF39515.1 - 0.0043 15.9 0.1 0.0058 15.5 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Aldo_ket_red PF00248.21 CCF39516.1 - 3.3e-46 157.8 0.0 4.4e-46 157.4 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Frankia_peptide PF14407.6 CCF39516.1 - 0.021 14.8 0.0 0.074 13.0 0.0 1.9 1 0 0 1 1 1 0 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. Med21 PF11221.8 CCF39517.1 - 1.9e-38 131.9 4.2 2.2e-38 131.7 4.2 1.0 1 0 0 1 1 1 1 Subunit 21 of Mediator complex Med9 PF07544.13 CCF39517.1 - 0.0006 19.9 5.9 0.0014 18.7 0.7 2.6 1 1 1 2 2 2 1 RNA polymerase II transcription mediator complex subunit 9 Herpes_UL6 PF01763.16 CCF39517.1 - 0.033 12.7 0.1 0.033 12.7 0.1 1.0 1 0 0 1 1 1 0 Herpesvirus UL6 like DUF3802 PF12290.8 CCF39517.1 - 0.15 12.5 1.2 0.29 11.7 0.8 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3802) TMF_DNA_bd PF12329.8 CCF39517.1 - 0.85 9.7 7.5 7.2 6.7 7.6 2.1 1 1 0 1 1 1 0 TATA element modulatory factor 1 DNA binding DUF2034 PF10356.9 CCF39518.1 - 5.1e-29 101.0 0.0 3.3e-15 56.0 0.0 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF2034) Mrr_cat PF04471.12 CCF39518.1 - 7.6e-05 22.7 0.0 0.00015 21.8 0.0 1.5 1 0 0 1 1 1 1 Restriction endonuclease adh_short PF00106.25 CCF39519.1 - 1.1e-23 83.7 0.3 2.6e-20 72.7 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCF39519.1 - 4.9e-13 49.2 0.2 1.4e-10 41.1 0.2 2.1 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF39519.1 - 6.4e-11 42.5 0.1 2.2e-10 40.8 0.0 1.7 1 1 1 2 2 2 1 KR domain Epimerase PF01370.21 CCF39519.1 - 8.3e-06 25.4 0.1 1.3e-05 24.8 0.1 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 CCF39519.1 - 0.0017 17.6 0.1 0.0034 16.6 0.0 1.5 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein Patatin PF01734.22 CCF39520.1 - 0.0018 18.5 0.1 0.002 18.3 0.1 1.1 1 0 0 1 1 1 1 Patatin-like phospholipase M20_dimer PF07687.14 CCF39521.1 - 1.5e-22 79.6 0.1 2.9e-22 78.6 0.1 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M20 PF01546.28 CCF39521.1 - 7.3e-20 71.6 0.4 2.1e-18 66.8 0.4 2.2 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M28 PF04389.17 CCF39521.1 - 0.0012 18.6 0.0 0.002 17.9 0.0 1.6 1 1 0 1 1 1 1 Peptidase family M28 Methyltransf_3 PF01596.17 CCF39524.1 - 3.1e-31 108.2 0.0 4.9e-31 107.6 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase PCMT PF01135.19 CCF39524.1 - 4.7e-10 39.6 0.0 6.2e-10 39.2 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_24 PF13578.6 CCF39524.1 - 2.5e-09 38.1 0.0 5.8e-09 36.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF39524.1 - 1e-07 31.9 0.0 1.5e-07 31.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF39524.1 - 1.7e-05 25.4 0.0 3.7e-05 24.4 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_4 PF02390.17 CCF39524.1 - 0.016 14.7 0.0 0.028 13.9 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase Epiglycanin_TR PF05647.11 CCF39525.1 - 0.28 11.1 11.5 2.2 8.2 2.4 2.5 1 1 1 2 2 2 0 Tandem-repeating region of mucin, epiglycanin-like PGK PF00162.19 CCF39526.1 - 8.8e-151 502.1 2.1 9.9e-151 502.0 2.1 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase PA PF02225.22 CCF39526.1 - 0.00082 19.4 0.2 0.063 13.3 0.0 3.2 3 1 1 4 4 4 1 PA domain FIVAR PF07554.13 CCF39526.1 - 0.0099 16.6 0.3 8.3 7.3 0.0 3.7 4 0 0 4 4 4 1 FIVAR domain DUF3530 PF12048.8 CCF39526.1 - 0.18 11.2 0.0 0.26 10.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) DSS1_SEM1 PF05160.13 CCF39527.1 - 9e-24 83.3 12.7 9e-24 83.3 12.7 1.4 1 1 0 1 1 1 1 DSS1/SEM1 family MFS_1 PF07690.16 CCF39528.1 - 9.4e-17 60.9 55.7 1.6e-13 50.4 44.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Lactamase_B_2 PF12706.7 CCF39529.1 - 1.6e-15 57.2 0.1 2.3e-15 56.6 0.1 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 CCF39529.1 - 9.3e-13 48.4 0.0 1.5e-12 47.7 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 CCF39529.1 - 0.052 13.6 0.3 1.9 8.4 0.2 2.2 2 0 0 2 2 2 0 Metallo-beta-lactamase superfamily Tannase PF07519.11 CCF39530.1 - 6.2e-124 414.5 0.1 7.2e-124 414.2 0.1 1.0 1 0 0 1 1 1 1 Tannase and feruloyl esterase Hydrolase_4 PF12146.8 CCF39530.1 - 0.04 13.2 0.0 0.08 12.2 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CCF39530.1 - 0.043 13.5 0.0 0.075 12.7 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF1391 PF07151.12 CCF39530.1 - 0.69 9.8 2.5 3.9 7.4 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1391) AMP-binding PF00501.28 CCF39531.1 - 1e-47 162.7 0.1 1.3e-47 162.4 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.25 CCF39531.1 - 7e-10 39.1 0.0 2.2e-09 37.5 0.1 1.8 2 0 0 2 2 2 1 Phosphopantetheine attachment site AMP-binding_C PF13193.6 CCF39531.1 - 0.16 13.0 0.0 0.62 11.1 0.0 2.0 1 1 0 1 1 1 0 AMP-binding enzyme C-terminal domain MFS_1 PF07690.16 CCF39532.1 - 1.9e-28 99.4 26.6 6.2e-28 97.7 26.9 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily 7TM_GPCR_Sra PF02117.16 CCF39532.1 - 0.15 10.8 0.1 0.25 10.1 0.1 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Sra TPR_1 PF00515.28 CCF39533.1 - 1.1e-07 31.4 2.5 1.8e-05 24.3 0.2 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 CCF39533.1 - 2.8e-05 23.7 2.2 0.00024 20.7 0.1 3.1 3 0 0 3 3 3 1 TPR repeat TPR_2 PF07719.17 CCF39533.1 - 0.00013 21.8 0.2 0.00013 21.8 0.2 4.9 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.6 CCF39533.1 - 0.00014 21.7 4.9 0.046 13.8 0.1 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 CCF39533.1 - 0.0063 17.1 14.9 1.9 9.2 0.0 5.4 6 1 0 6 6 6 3 Tetratricopeptide repeat TPR_8 PF13181.6 CCF39533.1 - 0.017 15.3 1.4 0.58 10.5 0.1 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 CCF39533.1 - 0.042 14.7 0.1 0.042 14.7 0.1 5.3 6 0 0 6 6 6 0 Tetratricopeptide repeat Sod_Cu PF00080.20 CCF39536.1 - 7e-08 32.7 0.2 9.4e-08 32.3 0.2 1.2 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) FAD_binding_1 PF00667.20 CCF39537.1 - 2.1e-40 138.7 0.0 3.7e-40 137.9 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 CCF39537.1 - 3.8e-31 108.2 0.5 1e-30 106.8 0.0 2.0 3 0 0 3 3 3 1 Flavodoxin NAD_binding_1 PF00175.21 CCF39537.1 - 2.4e-21 76.4 0.0 5.6e-21 75.2 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain MFS_1 PF07690.16 CCF39539.1 - 2.1e-35 122.3 68.9 6.3e-35 120.7 49.0 2.6 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 CCF39539.1 - 0.00066 18.7 12.2 0.00066 18.7 12.2 2.6 2 1 1 3 3 3 1 MFS_1 like family DUF3272 PF11676.8 CCF39539.1 - 0.025 14.8 0.7 0.23 11.7 0.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3272) CxC2 PF18803.1 CCF39542.1 - 0.04 14.1 0.1 0.084 13.0 0.1 1.4 1 0 0 1 1 1 0 CxC2 like cysteine cluster associated with KDZ transposases Hist_deacetyl PF00850.19 CCF39543.1 - 8.3e-82 275.1 0.0 1.4e-81 274.3 0.0 1.4 1 0 0 1 1 1 1 Histone deacetylase domain JAB PF01398.21 CCF39544.1 - 6.3e-33 113.3 0.0 1.2e-32 112.4 0.0 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 CCF39544.1 - 4e-12 46.5 0.6 8.5e-12 45.5 0.6 1.5 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function Prok-JAB PF14464.6 CCF39544.1 - 4e-07 29.8 0.0 7.4e-07 29.0 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain AP3D1 PF06375.11 CCF39545.1 - 0.1 12.8 4.0 0.11 12.7 4.0 1.1 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Glyco_hydro_10 PF00331.20 CCF39546.1 - 3.2e-56 190.8 0.0 3.5e-56 190.7 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 Phosphoesterase PF04185.14 CCF39546.1 - 0.11 11.7 0.0 0.13 11.5 0.0 1.1 1 0 0 1 1 1 0 Phosphoesterase family MFS_1 PF07690.16 CCF39547.1 - 1.6e-31 109.5 28.2 1.6e-31 109.5 28.2 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily OSTbeta PF15048.6 CCF39547.1 - 0.013 15.7 0.0 0.024 14.8 0.0 1.4 1 0 0 1 1 1 0 Organic solute transporter subunit beta protein Rad51 PF08423.11 CCF39547.1 - 0.021 14.1 0.0 0.033 13.4 0.0 1.2 1 0 0 1 1 1 0 Rad51 Ribosomal_L7Ae PF01248.26 CCF39549.1 - 6.1e-08 32.3 0.0 7.8e-08 32.0 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Glyco_hydro_16 PF00722.21 CCF39550.1 - 1.7e-09 37.4 0.4 2.8e-09 36.7 0.4 1.4 1 1 0 1 1 1 1 Glycosyl hydrolases family 16 2-oxoacid_dh PF00198.23 CCF39551.1 - 5.7e-79 264.8 0.0 8.1e-79 264.3 0.0 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 CCF39551.1 - 3.9e-18 65.0 4.0 7.3e-18 64.2 4.0 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 CCF39551.1 - 0.0022 17.8 0.4 0.59 10.0 0.0 2.4 1 1 1 2 2 2 2 Biotin-lipoyl like HlyD_3 PF13437.6 CCF39551.1 - 0.0027 18.4 0.6 0.15 12.7 0.3 2.4 1 1 1 2 2 2 2 HlyD family secretion protein RnfC_N PF13375.6 CCF39551.1 - 0.006 16.5 1.5 2.2 8.3 0.0 3.2 1 1 2 3 3 3 1 RnfC Barrel sandwich hybrid domain GCV_H PF01597.19 CCF39551.1 - 0.057 13.3 0.3 0.11 12.3 0.3 1.5 1 0 0 1 1 1 0 Glycine cleavage H-protein FAM76 PF16046.5 CCF39551.1 - 0.15 11.3 9.6 4.6 6.5 6.5 2.1 2 0 0 2 2 2 0 FAM76 protein Presenilin PF01080.17 CCF39551.1 - 0.92 8.2 6.3 1.3 7.7 6.3 1.1 1 0 0 1 1 1 0 Presenilin Mitofilin PF09731.9 CCF39551.1 - 1 8.1 14.2 1.3 7.7 14.2 1.2 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Ndc1_Nup PF09531.10 CCF39551.1 - 2.1 6.9 7.2 3 6.4 7.2 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Coilin_N PF15862.5 CCF39551.1 - 2.5 7.9 6.4 4.9 6.9 6.4 1.5 1 0 0 1 1 1 0 Coilin N-terminus SPATA3 PF15662.5 CCF39551.1 - 4.5 7.8 12.1 8 7.1 12.1 1.3 1 0 0 1 1 1 0 Spermatogenesis-associated protein 3 family DUF2052 PF09747.9 CCF39551.1 - 6 7.0 9.4 9.7 6.3 9.4 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) DUF4551 PF15087.6 CCF39551.1 - 6.1 5.6 6.7 7.3 5.3 6.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Apt1 PF10351.9 CCF39551.1 - 6.5 5.5 9.3 9.1 5.0 9.3 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Catalase PF00199.19 CCF39553.1 - 1e-23 84.1 0.2 1.4e-23 83.7 0.2 1.2 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 CCF39553.1 - 1.8e-15 56.9 0.1 3.5e-15 55.9 0.1 1.5 1 0 0 1 1 1 1 Catalase-related immune-responsive DJ-1_PfpI PF01965.24 CCF39554.1 - 4.4e-17 62.4 0.0 7.5e-17 61.6 0.0 1.3 1 1 0 1 1 1 1 DJ-1/PfpI family GATase_3 PF07685.14 CCF39554.1 - 0.14 11.7 0.0 0.23 11.1 0.0 1.3 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain IU_nuc_hydro PF01156.19 CCF39555.1 - 6.1e-14 52.3 0.0 1e-13 51.6 0.0 1.3 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase Amidase PF01425.21 CCF39556.1 - 4.7e-33 114.8 0.6 8.6e-32 110.7 0.3 2.0 2 0 0 2 2 2 1 Amidase MafB PF06255.13 CCF39556.1 - 0.06 12.8 0.1 0.13 11.7 0.1 1.5 1 0 0 1 1 1 0 Neisseria toxin MafB BT1 PF03092.16 CCF39556.1 - 1.1 7.4 2.2 0.86 7.8 0.2 1.6 2 0 0 2 2 2 0 BT1 family MFS_1 PF07690.16 CCF39557.1 - 6e-22 78.0 18.0 7.8e-22 77.7 18.0 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF2070 PF09843.9 CCF39557.1 - 0.044 12.1 4.2 0.057 11.7 4.2 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) TMEM107 PF14995.6 CCF39557.1 - 1.2 9.5 12.1 0.055 13.9 4.1 2.6 1 1 1 2 2 2 0 Transmembrane protein Peptidase_U4 PF03419.13 CCF39557.1 - 1.6 8.0 9.1 2.2 7.5 9.1 1.1 1 0 0 1 1 1 0 Sporulation factor SpoIIGA Ank_2 PF12796.7 CCF39558.1 - 9.2e-22 77.4 20.3 0.0012 19.4 0.0 11.6 8 2 3 12 12 12 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CCF39558.1 - 7.5e-14 51.9 13.2 0.31 11.7 0.1 12.8 10 3 4 14 14 14 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCF39558.1 - 1.8e-07 30.9 21.2 6.2 7.7 0.0 13.9 18 1 1 19 19 19 2 Ankyrin repeat Ank_5 PF13857.6 CCF39558.1 - 0.00023 21.4 7.2 2.4 8.6 0.0 8.4 10 0 0 10 10 10 1 Ankyrin repeats (many copies) Ank PF00023.30 CCF39558.1 - 1.3 9.6 30.9 7.8 7.1 0.1 10.8 11 2 2 13 13 13 0 Ankyrin repeat Gly-zipper_Omp PF13488.6 CCF39559.1 - 0.00016 21.6 2.2 0.00029 20.8 2.2 1.3 1 0 0 1 1 1 1 Glycine zipper Gly-zipper_YMGG PF13441.6 CCF39559.1 - 0.011 15.4 2.9 0.019 14.7 2.9 1.3 1 0 0 1 1 1 0 YMGG-like Gly-zipper Rick_17kDa_Anti PF05433.15 CCF39559.1 - 0.069 13.0 5.7 0.13 12.1 5.7 1.3 1 0 0 1 1 1 0 Glycine zipper 2TM domain SNF PF00209.18 CCF39560.1 - 1.5e-40 139.4 11.5 7.2e-39 133.9 11.5 2.0 1 1 0 1 1 1 1 Sodium:neurotransmitter symporter family DUF4605 PF15378.6 CCF39560.1 - 0.23 11.3 0.1 0.23 11.3 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4605) DUF3810 PF12725.7 CCF39560.1 - 4.5 6.5 5.7 0.36 10.1 0.9 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) SNN_cytoplasm PF09051.10 CCF39562.1 - 0.091 12.6 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 Stannin cytoplasmic Aa_trans PF01490.18 CCF39563.1 - 5.1e-26 91.3 24.0 5.1e-26 91.3 24.0 1.8 2 0 0 2 2 2 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 CCF39563.1 - 2.2e-07 30.3 11.6 2.2e-07 30.3 11.6 2.5 2 1 0 3 3 3 1 Tryptophan/tyrosine permease family DUF202 PF02656.15 CCF39563.1 - 0.62 10.5 17.7 1.4 9.4 0.0 4.8 4 2 0 4 4 4 0 Domain of unknown function (DUF202) An_peroxidase PF03098.15 CCF39565.1 - 4.6e-30 104.7 0.0 1.6e-21 76.5 0.0 3.5 1 1 1 2 2 2 2 Animal haem peroxidase p450 PF00067.22 CCF39565.1 - 2.3e-08 33.3 0.0 5.4e-07 28.7 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 DUF2235 PF09994.9 CCF39566.1 - 5.7e-88 295.0 0.1 7.8e-88 294.6 0.1 1.2 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) Tautomerase_3 PF14832.6 CCF39567.1 - 6.3e-11 42.6 0.0 1.8e-10 41.2 0.0 1.7 1 1 0 1 1 1 1 Putative oxalocrotonate tautomerase enzyme p450 PF00067.22 CCF39568.1 - 4e-40 138.0 0.0 5.6e-40 137.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Sugar_tr PF00083.24 CCF39569.1 - 6.9e-112 374.6 24.6 7.9e-112 374.4 24.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF39569.1 - 1.5e-19 70.1 26.1 1.5e-19 70.1 26.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 CCF39569.1 - 0.00049 18.8 0.3 0.00049 18.8 0.3 3.8 2 1 2 4 4 4 1 MFS/sugar transport protein Ycf70 PF17382.2 CCF39569.1 - 0.64 10.4 7.2 99 3.4 0.3 4.7 5 1 0 5 5 5 0 Uncharacterized Ycf70-like DUF1772 PF08592.11 CCF39569.1 - 6.4 7.1 13.1 16 5.8 0.4 3.9 3 2 0 3 3 3 0 Domain of unknown function (DUF1772) Lactonase PF10282.9 CCF39571.1 - 4.4e-06 26.2 0.3 0.0025 17.2 0.0 3.3 1 1 0 2 2 2 2 Lactonase, 7-bladed beta-propeller DUF1815 PF08844.10 CCF39571.1 - 0.027 14.4 0.0 0.055 13.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1815) AA_permease PF00324.21 CCF39572.1 - 7.7e-101 338.0 37.1 9.3e-101 337.8 37.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CCF39572.1 - 4.4e-22 78.5 39.7 5.8e-22 78.1 39.7 1.0 1 0 0 1 1 1 1 Amino acid permease Ole-e-6 PF09253.10 CCF39572.1 - 0.013 15.5 0.4 0.027 14.4 0.4 1.5 1 0 0 1 1 1 0 Pollen allergen ole e 6 GST_C_3 PF14497.6 CCF39574.1 - 6.9e-06 26.2 0.0 1.5e-05 25.1 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 CCF39574.1 - 0.00083 19.5 0.0 0.0016 18.6 0.0 1.5 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 CCF39574.1 - 0.0024 18.2 0.0 0.0058 16.9 0.0 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 CCF39574.1 - 0.015 15.7 0.1 0.35 11.3 0.0 2.6 2 1 1 3 3 3 0 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CCF39574.1 - 0.019 15.2 0.0 0.052 13.9 0.0 1.8 1 1 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CCF39574.1 - 0.035 14.1 0.0 0.071 13.1 0.0 1.7 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain p450 PF00067.22 CCF39575.1 - 6.1e-28 97.8 0.0 8.1e-28 97.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 adh_short PF00106.25 CCF39577.1 - 6.7e-12 45.3 0.9 1e-11 44.7 0.9 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF39577.1 - 7.8e-10 38.7 0.3 1.1e-09 38.2 0.3 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.6 CCF39577.1 - 5.1e-07 29.8 2.0 8.7e-07 29.0 2.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 CCF39577.1 - 0.0005 20.0 0.6 0.00083 19.3 0.6 1.3 1 0 0 1 1 1 1 KR domain NmrA PF05368.13 CCF39577.1 - 0.00053 19.6 2.9 0.00074 19.1 3.0 1.4 1 1 0 1 1 1 1 NmrA-like family PALP PF00291.25 CCF39577.1 - 0.0013 18.3 2.4 0.0025 17.3 2.4 1.6 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Semialdhyde_dh PF01118.24 CCF39577.1 - 0.0055 17.1 0.7 0.015 15.7 0.7 1.7 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Epimerase PF01370.21 CCF39577.1 - 0.01 15.3 0.3 0.015 14.8 0.3 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CCF39577.1 - 0.012 15.0 0.3 0.016 14.6 0.3 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase ADH_zinc_N PF00107.26 CCF39577.1 - 0.039 13.9 0.9 0.091 12.7 0.9 1.6 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Ketoacyl-synt_C PF02801.22 CCF39578.1 - 5.8e-30 103.7 2.3 6.7e-30 103.5 0.3 2.2 3 0 0 3 3 3 1 Beta-ketoacyl synthase, C-terminal domain Acyl_transf_1 PF00698.21 CCF39578.1 - 6.1e-27 94.9 0.3 8.2e-19 68.2 0.8 2.3 1 1 1 2 2 2 2 Acyl transferase domain KAsynt_C_assoc PF16197.5 CCF39578.1 - 0.00036 21.0 0.0 0.00087 19.7 0.0 1.6 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension TraI_2 PF07514.11 CCF39581.1 - 0.038 12.9 0.3 0.041 12.8 0.3 1.0 1 0 0 1 1 1 0 Putative helicase Amino_oxidase PF01593.24 CCF39582.1 - 2.1e-38 132.8 0.0 2.2e-29 103.1 0.1 2.1 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CCF39582.1 - 3.6e-06 27.1 0.0 1e-05 25.6 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain YdjM PF04307.14 CCF39582.1 - 0.052 12.9 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 LexA-binding, inner membrane-associated putative hydrolase NAD_binding_4 PF07993.12 CCF39583.1 - 4.8e-23 81.6 0.0 6.1e-23 81.3 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.21 CCF39583.1 - 0.0013 18.3 0.0 0.0017 17.9 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family SIR2 PF02146.17 CCF39584.1 - 4.6e-62 209.1 0.0 7.2e-62 208.4 0.0 1.3 1 0 0 1 1 1 1 Sir2 family TPP_enzyme_M PF00205.22 CCF39584.1 - 1.1e-05 25.2 0.1 0.01 15.6 0.0 2.3 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, central domain DUF592 PF04574.13 CCF39584.1 - 8.4e-05 22.4 0.0 0.00016 21.5 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF592) Mito_carr PF00153.27 CCF39585.1 - 1.8e-12 47.0 0.0 2.6e-12 46.5 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial carrier protein F-box-like PF12937.7 CCF39586.1 - 0.00053 19.8 0.2 0.00094 19.0 0.2 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCF39586.1 - 0.012 15.5 0.0 0.02 14.8 0.0 1.4 1 0 0 1 1 1 0 F-box domain zinc_ribbon_16 PF17034.5 CCF39587.1 - 7.3e-16 58.5 9.7 1.9e-15 57.2 9.7 1.8 1 1 0 1 1 1 1 Zinc-ribbon like family Zn_ribbon_17 PF17120.5 CCF39587.1 - 4.3e-06 26.2 5.8 4.3e-06 26.2 5.8 2.3 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type DZR PF12773.7 CCF39587.1 - 0.54 10.3 4.6 2.3 8.3 2.3 2.8 2 1 0 2 2 2 0 Double zinc ribbon dNK PF01712.19 CCF39588.1 - 0.012 15.5 0.4 0.027 14.3 0.4 1.6 1 0 0 1 1 1 0 Deoxynucleoside kinase Phage_Mu_Gam PF07352.12 CCF39588.1 - 0.11 12.5 7.3 1.3 8.9 0.8 2.4 2 0 0 2 2 2 0 Bacteriophage Mu Gam like protein VPS9 PF02204.18 CCF39590.1 - 8.7e-26 90.2 0.0 1.6e-25 89.3 0.0 1.5 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain DUF5601 PF18151.1 CCF39590.1 - 0.019 15.3 0.1 0.061 13.6 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5601) Sigma70_ner PF04546.13 CCF39590.1 - 0.32 10.8 3.8 0.18 11.7 1.1 1.8 1 1 1 2 2 2 0 Sigma-70, non-essential region Methyltransf_23 PF13489.6 CCF39591.1 - 5e-21 75.2 0.0 6.8e-21 74.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF39591.1 - 1.6e-11 44.8 0.0 4.1e-11 43.4 0.0 1.7 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF39591.1 - 3e-09 37.4 0.0 6.2e-09 36.4 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF39591.1 - 3.3e-09 36.7 0.0 4.2e-08 33.1 0.0 2.4 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF39591.1 - 6.8e-08 33.2 0.0 4.1e-07 30.7 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 CCF39591.1 - 0.001 19.2 0.0 0.0015 18.7 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase MTS PF05175.14 CCF39591.1 - 0.034 13.7 0.0 0.084 12.4 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase small domain CMAS PF02353.20 CCF39591.1 - 0.095 12.0 0.0 0.17 11.1 0.0 1.4 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase Gamma-thionin PF00304.20 CCF39592.1 - 0.19 12.0 14.4 0.3 11.4 3.1 2.3 2 0 0 2 2 2 0 Gamma-thionin family Colipase-like PF15083.6 CCF39592.1 - 2.3 8.4 5.3 10 6.3 0.5 2.1 2 0 0 2 2 2 0 Colipase-like Colipase PF01114.18 CCF39592.1 - 3.7 7.3 16.7 4.5 7.0 5.6 2.3 2 0 0 2 2 2 0 Colipase, N-terminal domain Toxin_11 PF07473.11 CCF39592.1 - 9.4 6.4 16.3 11 6.2 4.3 2.4 2 0 0 2 2 2 0 Spasmodic peptide gm9a; conotoxin from Conus species PepX_C PF08530.10 CCF39593.1 - 7.4e-06 26.1 0.0 9.7e-06 25.7 0.0 1.1 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain FAA_hydrolase PF01557.18 CCF39594.1 - 7.1e-50 169.7 0.0 9.6e-50 169.3 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FAA_hydrolase_N PF09298.11 CCF39594.1 - 1.5e-13 50.9 0.0 6.6e-13 48.8 0.0 1.9 2 0 0 2 2 2 1 Fumarylacetoacetase N-terminal Zn_clus PF00172.18 CCF39596.1 - 0.00077 19.5 12.3 0.0014 18.7 12.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CHZ PF09649.10 CCF39596.1 - 0.0062 16.0 0.0 0.0062 16.0 0.0 2.0 2 0 0 2 2 2 1 Histone chaperone domain CHZ MFS_1 PF07690.16 CCF39598.1 - 5.9e-32 110.9 43.9 5.9e-32 110.9 43.9 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2070 PF09843.9 CCF39598.1 - 0.036 12.4 9.8 0.051 11.9 9.8 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Tax PF02959.16 CCF39598.1 - 0.044 13.2 0.5 1.8 8.0 0.1 2.2 2 0 0 2 2 2 0 HTLV Tax Abhydrolase_3 PF07859.13 CCF39599.1 - 2.5e-05 24.3 0.2 0.00096 19.1 0.2 2.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCF39599.1 - 0.00017 22.3 4.3 0.00029 21.5 4.3 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCF39599.1 - 0.058 12.7 0.0 0.58 9.4 0.0 2.0 2 0 0 2 2 2 0 Serine aminopeptidase, S33 DUF1057 PF06342.12 CCF39599.1 - 0.18 10.8 0.0 0.29 10.1 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) Endosulfine PF04667.17 CCF39600.1 - 5.9e-28 96.8 0.1 9.3e-28 96.2 0.1 1.3 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region UPF0160 PF03690.13 CCF39601.1 - 3.9e-133 444.0 0.0 4.4e-133 443.8 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) Diphthamide_syn PF01866.17 CCF39602.1 - 4.2e-117 390.9 0.0 5.2e-117 390.6 0.0 1.1 1 0 0 1 1 1 1 Putative diphthamide synthesis protein Aldose_epim PF01263.20 CCF39603.1 - 2.2e-50 171.7 0.2 2.9e-50 171.3 0.2 1.2 1 0 0 1 1 1 1 Aldose 1-epimerase TPR_1 PF00515.28 CCF39604.1 - 1.5e-23 81.5 5.5 9.2e-08 31.6 0.0 6.1 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.17 CCF39604.1 - 3.5e-22 76.7 11.8 1.3e-06 28.1 0.1 6.4 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_14 PF13428.6 CCF39604.1 - 3.9e-18 64.6 5.6 7.2e-06 26.4 0.0 5.9 3 1 2 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.6 CCF39604.1 - 5.3e-18 65.4 8.4 1.2e-06 29.1 2.0 4.5 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 CCF39604.1 - 3.3e-15 55.5 8.2 2.4e-07 30.3 0.0 4.7 3 2 2 5 5 5 3 TPR repeat TPR_17 PF13431.6 CCF39604.1 - 9.1e-14 50.8 4.1 0.0055 17.0 0.0 5.3 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 CCF39604.1 - 9.8e-14 50.4 5.0 2e-05 24.4 0.0 6.1 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 CCF39604.1 - 5.5e-13 49.2 15.1 0.0003 21.3 1.2 5.6 5 1 1 6 6 6 4 Tetratricopeptide repeat TPR_7 PF13176.6 CCF39604.1 - 5.8e-13 47.9 3.3 0.032 14.3 0.0 6.2 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_6 PF13174.6 CCF39604.1 - 9.4e-10 38.5 2.5 0.25 12.1 0.2 6.4 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_12 PF13424.6 CCF39604.1 - 2.9e-09 37.1 9.7 0.013 15.8 0.2 5.0 3 1 1 5 5 5 4 Tetratricopeptide repeat TPR_9 PF13371.6 CCF39604.1 - 5e-09 36.2 1.7 0.011 15.9 0.4 3.6 2 2 1 3 3 3 2 Tetratricopeptide repeat TPR_20 PF14561.6 CCF39604.1 - 2.2e-07 31.1 8.7 0.004 17.5 0.2 4.7 4 1 1 5 5 4 3 Tetratricopeptide repeat ANAPC3 PF12895.7 CCF39604.1 - 0.0014 18.8 6.8 0.27 11.5 0.4 2.6 2 0 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 DUF484 PF04340.12 CCF39604.1 - 0.002 17.9 0.0 0.0071 16.1 0.0 1.9 1 0 0 1 1 1 1 Protein of unknown function, DUF484 TPR_15 PF13429.6 CCF39604.1 - 0.011 15.0 7.6 0.2 10.8 0.5 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 CCF39604.1 - 0.024 14.5 0.3 0.024 14.5 0.3 4.5 6 0 0 6 6 5 0 Tetratricopeptide repeat NatB_MDM20 PF09797.9 CCF39604.1 - 0.056 12.4 0.0 0.12 11.3 0.0 1.4 1 0 0 1 1 1 0 N-acetyltransferase B complex (NatB) non catalytic subunit DUF4919 PF16266.5 CCF39604.1 - 0.057 13.4 1.0 0.18 11.7 0.0 2.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4919) DUF1641 PF07849.11 CCF39604.1 - 0.11 12.4 0.2 0.24 11.3 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1641) Xpo1 PF08389.12 CCF39605.1 - 5.4e-10 39.5 0.0 7.7e-10 39.0 0.0 1.3 1 0 0 1 1 1 1 Exportin 1-like protein IBN_N PF03810.19 CCF39605.1 - 0.00015 21.6 0.0 0.00025 20.9 0.0 1.4 1 0 0 1 1 1 1 Importin-beta N-terminal domain FAM178 PF14816.6 CCF39605.1 - 0.018 14.0 0.0 0.023 13.7 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function, FAM178 adh_short PF00106.25 CCF39606.1 - 1e-14 54.5 0.0 1.5e-09 37.6 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCF39606.1 - 9.3e-11 41.7 0.1 1.4e-07 31.4 0.0 2.1 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF39606.1 - 0.089 12.7 0.1 0.21 11.5 0.0 1.6 2 0 0 2 2 2 0 KR domain Pkinase PF00069.25 CCF39607.1 - 4.9e-11 42.5 0.0 8.6e-11 41.7 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF39607.1 - 1.1e-06 28.1 0.0 3.8e-06 26.4 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF39607.1 - 0.00033 20.1 0.0 0.0011 18.4 0.0 1.8 2 0 0 2 2 2 1 Kinase-like ORC4_C PF14629.6 CCF39608.1 - 3.5e-65 219.5 0.0 6e-65 218.7 0.0 1.4 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 4 C-terminus AAA_16 PF13191.6 CCF39608.1 - 3.2e-13 50.4 0.1 9.9e-13 48.8 0.1 1.9 1 0 0 1 1 1 1 AAA ATPase domain PHD PF00628.29 CCF39608.1 - 1.8e-11 43.7 7.7 3.5e-11 42.8 7.7 1.5 1 0 0 1 1 1 1 PHD-finger AAA PF00004.29 CCF39608.1 - 6.8e-09 36.2 0.0 1.5e-08 35.1 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) PHD_2 PF13831.6 CCF39608.1 - 1.8e-08 33.8 4.1 3.7e-08 32.8 4.1 1.5 1 0 0 1 1 1 1 PHD-finger AAA_22 PF13401.6 CCF39608.1 - 4e-08 33.6 0.4 1.8e-07 31.5 0.0 2.2 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 CCF39608.1 - 1.4e-06 28.3 0.0 6.1e-06 26.3 0.0 2.0 1 1 0 1 1 1 1 NACHT domain KAP_NTPase PF07693.14 CCF39608.1 - 9.1e-06 25.1 0.0 3.2e-05 23.3 0.0 1.6 1 1 1 2 2 2 1 KAP family P-loop domain AAA_19 PF13245.6 CCF39608.1 - 1.7e-05 25.1 0.1 4.9e-05 23.7 0.1 1.7 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 CCF39608.1 - 0.00012 22.1 0.0 0.00028 20.9 0.0 1.6 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea NB-ARC PF00931.22 CCF39608.1 - 0.00019 20.7 0.1 0.00037 19.8 0.1 1.4 1 0 0 1 1 1 1 NB-ARC domain TniB PF05621.11 CCF39608.1 - 0.00021 20.8 0.1 0.0035 16.8 0.1 2.3 1 1 0 1 1 1 1 Bacterial TniB protein AAA_30 PF13604.6 CCF39608.1 - 0.00021 21.0 0.1 0.00054 19.7 0.1 1.7 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 CCF39608.1 - 0.00036 20.6 0.1 0.0011 19.0 0.1 2.0 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.27 CCF39608.1 - 0.00081 19.9 0.1 0.0033 18.0 0.0 2.1 2 1 0 2 2 1 1 ABC transporter ATP-synt_ab PF00006.25 CCF39608.1 - 0.00097 18.8 0.0 0.0024 17.6 0.0 1.6 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain DUF815 PF05673.13 CCF39608.1 - 0.0016 17.7 0.1 0.0029 16.8 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) SMC_N PF02463.19 CCF39608.1 - 0.0021 17.5 0.0 0.0072 15.8 0.0 1.8 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain C1_1 PF00130.22 CCF39608.1 - 0.0046 16.8 0.6 0.012 15.5 0.6 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) FYVE_2 PF02318.16 CCF39608.1 - 0.0093 16.2 2.0 0.021 15.0 2.0 1.5 1 0 0 1 1 1 1 FYVE-type zinc finger AAA_29 PF13555.6 CCF39608.1 - 0.015 15.1 0.0 0.035 13.9 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Sigma54_activat PF00158.26 CCF39608.1 - 0.025 14.3 0.1 0.045 13.5 0.1 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain RNA_helicase PF00910.22 CCF39608.1 - 0.035 14.5 0.0 0.31 11.4 0.0 2.4 2 0 0 2 2 2 0 RNA helicase AAA_7 PF12775.7 CCF39608.1 - 0.043 13.3 0.0 0.1 12.1 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region Prok-RING_1 PF14446.6 CCF39608.1 - 0.073 13.0 7.7 0.16 11.9 7.7 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 AAA_28 PF13521.6 CCF39608.1 - 0.084 13.1 0.0 0.24 11.6 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 CCF39608.1 - 0.087 13.4 0.1 0.35 11.4 0.0 2.1 2 0 0 2 2 1 0 AAA domain Viral_helicase1 PF01443.18 CCF39608.1 - 0.091 12.5 0.8 0.48 10.1 0.0 2.5 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase MobB PF03205.14 CCF39608.1 - 0.094 12.6 0.0 0.27 11.1 0.0 1.8 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B MMR_HSR1 PF01926.23 CCF39608.1 - 0.13 12.4 0.0 0.42 10.7 0.0 2.0 1 1 0 1 1 1 0 50S ribosome-binding GTPase cobW PF02492.19 CCF39608.1 - 0.13 11.8 0.0 0.44 10.1 0.0 1.9 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_5 PF07728.14 CCF39608.1 - 0.16 11.9 0.0 0.54 10.2 0.0 2.0 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) PduV-EutP PF10662.9 CCF39608.1 - 0.18 11.6 0.2 0.59 9.9 0.2 2.0 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_23 PF13476.6 CCF39608.1 - 0.22 12.0 0.2 0.22 12.0 0.2 2.4 2 1 0 2 2 1 0 AAA domain zf-HC5HC2H PF13771.6 CCF39608.1 - 0.49 10.7 3.2 1.2 9.5 3.2 1.6 1 0 0 1 1 1 0 PHD-like zinc-binding domain Zf_RING PF16744.5 CCF39608.1 - 0.61 10.2 4.0 2.2 8.4 4.0 2.0 1 1 0 1 1 1 0 KIAA1045 RING finger MAGI_u1 PF16663.5 CCF39608.1 - 5.6 7.1 7.9 1.7 8.8 0.1 3.3 3 0 0 3 3 2 0 Unstructured region on MAGI BppU_N PF10651.9 CCF39609.1 - 0.059 13.1 0.2 0.1 12.3 0.2 1.3 1 0 0 1 1 1 0 BppU N-terminal domain DUF4307 PF14155.6 CCF39609.1 - 0.17 11.7 0.7 0.33 10.8 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4307) zf-HIT PF04438.16 CCF39609.1 - 0.2 11.6 0.3 0.38 10.7 0.3 1.4 1 0 0 1 1 1 0 HIT zinc finger Frag1 PF10277.9 CCF39610.1 - 6.4e-22 78.2 5.9 6.4e-22 78.2 5.9 3.0 3 1 0 3 3 3 2 Frag1/DRAM/Sfk1 family Exo_endo_phos PF03372.23 CCF39610.1 - 0.032 13.7 0.0 0.067 12.7 0.0 1.5 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family UCH PF00443.29 CCF39611.1 - 6.1e-40 137.3 0.0 9e-40 136.8 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RPT PF13446.6 CCF39611.1 - 5e-24 84.0 2.0 7.1e-11 41.9 0.1 3.0 3 0 0 3 3 3 2 A repeated domain in UCH-protein UCH_1 PF13423.6 CCF39611.1 - 1.7e-06 27.9 0.7 0.014 15.0 0.1 2.4 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Tim17 PF02466.19 CCF39612.1 - 9.7e-07 29.2 10.0 1.9e-06 28.2 8.9 1.9 1 1 1 2 2 2 1 Tim17/Tim22/Tim23/Pmp24 family rhaM PF05336.13 CCF39612.1 - 0.072 13.2 0.0 0.13 12.4 0.0 1.3 1 0 0 1 1 1 0 L-rhamnose mutarotase Cytochrom_B558a PF05038.13 CCF39612.1 - 0.85 9.2 3.4 0.35 10.4 0.2 1.9 2 1 0 2 2 2 0 Cytochrome Cytochrome b558 alpha-subunit ECH_1 PF00378.20 CCF39613.1 - 1.6e-16 60.4 0.0 1.9e-16 60.1 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CCF39613.1 - 0.18 11.3 0.0 1.5 8.3 0.0 1.9 1 1 0 1 1 1 0 Enoyl-CoA hydratase/isomerase NAD_binding_8 PF13450.6 CCF39614.1 - 1.2e-13 51.0 0.1 3.8e-13 49.5 0.1 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CCF39614.1 - 1.2e-09 38.2 0.2 3.8e-07 30.0 0.0 2.6 2 1 1 3 3 3 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCF39614.1 - 1.8e-06 27.4 0.0 0.00031 20.1 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCF39614.1 - 2.9e-05 24.5 0.0 0.3 11.7 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CCF39614.1 - 0.00015 21.0 0.0 0.00024 20.3 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 CCF39614.1 - 0.00043 19.1 0.0 0.026 13.2 0.0 2.1 2 0 0 2 2 2 1 HI0933-like protein NAD_binding_9 PF13454.6 CCF39614.1 - 0.0012 18.8 0.0 0.0055 16.7 0.0 2.0 2 0 0 2 2 2 1 FAD-NAD(P)-binding Thi4 PF01946.17 CCF39614.1 - 0.0015 17.8 0.0 0.0028 16.9 0.0 1.3 1 0 0 1 1 1 1 Thi4 family FAD_binding_3 PF01494.19 CCF39614.1 - 0.092 12.0 0.0 0.22 10.7 0.0 1.6 2 0 0 2 2 2 0 FAD binding domain Lycopene_cycl PF05834.12 CCF39614.1 - 0.1 11.6 0.0 0.16 11.0 0.0 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein NAD_binding_7 PF13241.6 CCF39614.1 - 0.16 12.5 0.0 0.39 11.2 0.0 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding Staph_opine_DH PF10100.9 CCF39614.1 - 0.23 10.1 0.0 3.4 6.2 0.0 2.0 2 0 0 2 2 2 0 Staphylopine dehydrogenase Shikimate_DH PF01488.20 CCF39614.1 - 0.23 11.5 0.0 0.42 10.7 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Sugar_tr PF00083.24 CCF39617.1 - 7.3e-96 321.8 23.1 8.9e-96 321.5 23.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF39617.1 - 1.7e-18 66.7 52.8 5.1e-16 58.6 27.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Trp_oprn_chp PF09534.10 CCF39617.1 - 0.024 14.4 0.5 1.5 8.6 0.0 2.5 3 0 0 3 3 3 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) TAF PF02969.17 CCF39617.1 - 0.15 12.3 0.1 0.29 11.3 0.1 1.5 1 0 0 1 1 1 0 TATA box binding protein associated factor (TAF) LapA_dom PF06305.11 CCF39617.1 - 0.17 11.7 2.7 6.3 6.7 0.1 3.3 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain WD40 PF00400.32 CCF39618.1 - 6.9e-12 45.7 1.7 0.028 15.3 0.1 4.5 4 0 0 4 4 4 4 WD domain, G-beta repeat PQQ_3 PF13570.6 CCF39618.1 - 0.0051 17.3 1.1 1.9 9.1 0.0 3.7 4 0 0 4 4 4 1 PQQ-like domain WD40_like PF17005.5 CCF39618.1 - 0.018 14.4 0.0 0.045 13.1 0.0 1.6 2 0 0 2 2 2 0 WD40-like domain Nup160 PF11715.8 CCF39618.1 - 0.033 12.9 0.0 5.9 5.4 0.0 2.1 2 0 0 2 2 2 0 Nucleoporin Nup120/160 DUF1556 PF07590.11 CCF39618.1 - 0.11 12.8 2.2 0.2 12.0 2.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1556) DUF737 PF05300.11 CCF39618.1 - 0.3 11.4 3.5 0.5 10.7 3.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF737) DUF3237 PF11578.8 CCF39619.1 - 2.5e-37 128.0 0.1 2.8e-37 127.8 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3237) DUF2264 PF10022.9 CCF39620.1 - 6.2e-18 65.0 0.0 6.9e-18 64.9 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2264) FH2 PF02181.23 CCF39621.1 - 1.4e-87 294.3 4.1 1.9e-87 293.8 4.1 1.1 1 0 0 1 1 1 1 Formin Homology 2 Domain Methyltransf_5 PF01795.19 CCF39621.1 - 0.0045 16.6 1.4 0.007 15.9 1.4 1.2 1 0 0 1 1 1 1 MraW methylase family DUF4634 PF15465.6 CCF39621.1 - 0.031 14.6 0.1 0.099 12.9 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4634) HET PF06985.11 CCF39623.1 - 4.2e-29 101.8 0.0 9e-29 100.7 0.0 1.6 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) zf-CCHC_2 PF13696.6 CCF39623.1 - 2.3 8.1 5.0 3.6 7.5 2.1 2.3 2 0 0 2 2 2 0 Zinc knuckle DUF3659 PF12396.8 CCF39625.1 - 4.3e-130 423.7 66.7 6.7e-23 80.4 1.8 7.7 7 0 0 7 7 7 7 Protein of unknown function (DUF3659) GCV_T_C PF08669.11 CCF39625.1 - 0.0097 15.8 6.6 4 7.4 0.0 5.1 6 1 0 6 6 6 3 Glycine cleavage T-protein C-terminal barrel domain Cys_Met_Meta_PP PF01053.20 CCF39627.1 - 2e-41 141.8 0.0 2.4e-41 141.5 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 CCF39627.1 - 0.0011 18.0 0.0 0.0016 17.4 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 CCF39627.1 - 0.024 13.8 0.0 0.049 12.8 0.0 1.4 1 1 0 1 1 1 0 Aminotransferase class I and II VIT PF08487.10 CCF39629.1 - 1.2e-32 112.4 0.1 2.4e-32 111.5 0.1 1.5 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA_3 PF13768.6 CCF39629.1 - 1.5e-28 99.7 0.0 2.6e-28 98.9 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VIT_2 PF13757.6 CCF39629.1 - 1.8e-12 47.0 0.1 4.4e-12 45.7 0.1 1.7 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA_2 PF13519.6 CCF39629.1 - 2.5e-08 34.5 0.0 7.4e-08 33.0 0.0 1.8 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 CCF39629.1 - 1.4e-07 31.9 0.0 2.3e-07 31.2 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 CCF39629.1 - 0.0049 16.3 0.1 0.015 14.7 0.1 1.7 1 1 0 1 1 1 1 VWA domain containing CoxE-like protein Baculo_19 PF04798.12 CCF39630.1 - 0.072 12.8 0.1 0.13 12.0 0.1 1.4 1 0 0 1 1 1 0 Baculovirus 19 kDa protein conserved region Pam17 PF08566.10 CCF39630.1 - 1.3 8.8 2.7 0.75 9.6 0.3 1.8 2 0 0 2 2 2 0 Mitochondrial import protein Pam17 E1-E2_ATPase PF00122.20 CCF39632.1 - 1.9e-14 53.6 0.4 1.9e-14 53.6 0.4 2.0 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_N PF00690.26 CCF39632.1 - 4e-06 26.4 0.1 1.2e-05 24.9 0.0 1.8 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus DUF4334 PF14232.6 CCF39633.1 - 1.4e-28 98.6 4.5 9.6e-28 95.9 1.8 2.7 3 0 0 3 3 3 1 Domain of unknown function (DUF4334) GXWXG PF14231.6 CCF39633.1 - 8.1e-26 89.9 0.2 1.8e-25 88.7 0.2 1.6 2 0 0 2 2 2 1 GXWXG protein Urease_linker PF18473.1 CCF39633.1 - 0.097 12.6 0.4 0.25 11.3 0.4 1.7 1 0 0 1 1 1 0 Urease subunit beta-alpha linker domain FAD_binding_4 PF01565.23 CCF39634.1 - 5.4e-17 61.8 3.5 8.2e-17 61.2 2.5 1.9 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.12 CCF39634.1 - 3.4e-05 23.8 0.2 0.00011 22.2 0.2 1.9 1 0 0 1 1 1 1 Berberine and berberine like DUF1765 PF08578.10 CCF39635.1 - 2.9e-44 150.5 1.6 5.2e-44 149.7 1.6 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1765) Cadherin_C PF01049.17 CCF39635.1 - 0.085 13.2 0.8 0.17 12.2 0.8 1.4 1 0 0 1 1 1 0 Cadherin cytoplasmic region NUC153 PF08159.12 CCF39636.1 - 5.3e-14 51.7 0.5 5.3e-14 51.7 0.5 3.5 3 0 0 3 3 3 2 NUC153 domain Glyco_transf_41 PF13844.6 CCF39637.1 - 1.9e-87 293.7 0.0 4.1e-53 180.5 0.0 3.3 1 1 2 3 3 3 3 Glycosyl transferase family 41 UAA PF08449.11 CCF39638.1 - 9.8e-08 31.5 9.2 1.2e-07 31.3 9.2 1.1 1 0 0 1 1 1 1 UAA transporter family adh_short PF00106.25 CCF39639.1 - 5.3e-29 101.1 0.0 7.8e-29 100.5 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF39639.1 - 2.2e-19 70.0 0.0 3.4e-19 69.3 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF39639.1 - 7.8e-09 35.7 0.0 1.4e-08 34.8 0.0 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF39639.1 - 1.8e-06 27.6 0.1 3.5e-06 26.7 0.1 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CCF39639.1 - 1.7e-05 24.0 0.1 2.4e-05 23.5 0.1 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 CCF39639.1 - 0.00011 21.5 0.0 0.00015 21.1 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 CCF39639.1 - 0.0025 17.0 0.0 0.0059 15.7 0.0 1.6 2 0 0 2 2 2 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 CCF39639.1 - 0.012 15.5 0.0 0.019 14.8 0.0 1.3 1 0 0 1 1 1 0 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 CCF39639.1 - 0.02 14.3 0.0 0.033 13.6 0.0 1.4 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase ARD PF03079.14 CCF39640.1 - 6.4e-39 133.7 1.5 7.9e-39 133.3 1.5 1.1 1 0 0 1 1 1 1 ARD/ARD' family Cupin_2 PF07883.11 CCF39640.1 - 2.9e-09 36.5 0.1 3.9e-09 36.1 0.1 1.2 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 CCF39640.1 - 0.0004 20.3 0.5 0.00048 20.0 0.5 1.3 1 1 0 1 1 1 1 AraC-like ligand binding domain p450 PF00067.22 CCF39641.1 - 3.1e-34 118.5 0.0 3.8e-34 118.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 AbrB_C PF18277.1 CCF39641.1 - 0.072 12.7 0.0 2.9 7.6 0.0 2.5 2 0 0 2 2 2 0 AbrB C-terminal domain DUF2783 PF10932.8 CCF39641.1 - 0.12 12.1 0.0 0.28 10.9 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2783) NADH_B2 PF14813.6 CCF39641.1 - 0.13 12.1 0.1 0.28 11.0 0.1 1.5 1 0 0 1 1 1 0 NADH dehydrogenase 1 beta subcomplex subunit 2 zf-C2H2 PF00096.26 CCF39642.1 - 1.1e-06 28.8 12.6 0.002 18.5 2.0 5.1 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCF39642.1 - 2.1e-06 28.0 13.9 0.00054 20.6 1.8 4.6 4 0 0 4 4 4 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CCF39642.1 - 0.0022 18.2 6.5 0.1 12.9 1.2 3.0 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CCF39642.1 - 0.15 12.5 7.1 0.16 12.4 0.2 3.1 3 0 0 3 3 3 0 Zinc-finger of C2H2 type Sina PF03145.16 CCF39642.1 - 0.16 11.9 2.7 0.36 10.7 2.7 1.5 1 0 0 1 1 1 0 Seven in absentia protein family DUF629 PF04780.12 CCF39642.1 - 3.3 6.1 5.5 2.9 6.3 2.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF629) FOXP-CC PF16159.5 CCF39642.1 - 4.7 7.9 5.9 15 6.3 0.7 3.3 2 1 1 3 3 3 0 FOXP coiled-coil domain zf-C2H2_2 PF12756.7 CCF39642.1 - 5.6 7.4 7.6 0.88 9.9 1.6 2.6 2 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) Cu-oxidase_3 PF07732.15 CCF39643.1 - 6.7e-38 129.3 3.3 1.5e-37 128.2 3.3 1.6 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 CCF39643.1 - 3.2e-35 120.9 1.7 3.2e-35 120.9 1.7 3.3 2 1 0 2 2 2 1 Multicopper oxidase Cu-oxidase PF00394.22 CCF39643.1 - 3.6e-24 85.7 0.1 3.6e-24 85.7 0.1 2.5 3 1 0 3 3 3 1 Multicopper oxidase DUF3669 PF12417.8 CCF39645.1 - 7e-28 96.6 0.2 1.5e-27 95.5 0.2 1.6 1 0 0 1 1 1 1 Zinc finger protein Metallophos PF00149.28 CCF39646.1 - 1.7e-09 38.4 0.0 1.2e-08 35.8 0.0 2.0 1 1 1 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CCF39646.1 - 1.3e-05 25.4 0.1 5.7e-05 23.4 0.0 2.0 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain HORMA PF02301.18 CCF39647.1 - 2.5e-33 115.5 0.0 3.2e-33 115.1 0.0 1.1 1 0 0 1 1 1 1 HORMA domain ATG101 PF07855.12 CCF39647.1 - 0.0013 18.7 0.3 0.0065 16.5 0.3 2.1 1 1 0 1 1 1 1 Autophagy-related protein 101 DUF2660 PF10859.8 CCF39647.1 - 0.031 14.8 0.0 0.067 13.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2660) DUF3530 PF12048.8 CCF39647.1 - 0.39 10.1 5.3 1.2 8.4 3.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3530) UCH PF00443.29 CCF39648.1 - 5.1e-35 121.2 0.0 9.5e-35 120.3 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP_var PF17807.1 CCF39648.1 - 2.3e-22 78.5 1.6 4.8e-21 74.3 0.1 2.5 2 0 0 2 2 2 1 Variant UBP zinc finger zf-UBP PF02148.19 CCF39648.1 - 7.9e-22 77.4 14.2 1.8e-19 69.8 2.2 3.1 3 0 0 3 3 3 2 Zn-finger in ubiquitin-hydrolases and other protein UBA PF00627.31 CCF39648.1 - 1e-19 70.0 0.1 2.4e-10 40.1 0.2 2.7 2 0 0 2 2 2 2 UBA/TS-N domain UCH_1 PF13423.6 CCF39648.1 - 7.1e-16 58.7 0.1 4.4e-14 52.8 0.0 3.3 3 1 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase UBA_3 PF09288.10 CCF39648.1 - 0.078 12.8 0.0 1.4 8.8 0.0 2.9 3 0 0 3 3 3 0 Fungal ubiquitin-associated domain NifU_N PF01592.16 CCF39649.1 - 2.4e-52 176.5 0.0 3e-52 176.1 0.0 1.1 1 0 0 1 1 1 1 NifU-like N terminal domain zf-CCCH PF00642.24 CCF39651.1 - 7.4e-23 79.9 33.6 6.3e-08 32.3 0.7 5.4 4 1 1 5 5 5 5 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 CCF39651.1 - 1e-19 69.9 32.5 1.1e-06 28.5 1.9 5.4 5 0 0 5 5 5 5 Zinc finger domain Torus PF16131.5 CCF39651.1 - 5e-12 46.5 24.4 0.0003 21.5 0.4 5.3 1 1 4 5 5 5 5 Torus domain zf-CCCH_4 PF18044.1 CCF39651.1 - 1e-10 41.1 35.3 9.4e-06 25.3 0.4 5.6 5 0 0 5 5 5 5 CCCH-type zinc finger zf-CCCH_3 PF15663.5 CCF39651.1 - 0.0024 18.1 0.6 0.0024 18.1 0.6 2.8 1 1 2 3 3 3 1 Zinc-finger containing family zf-C3H1 PF10650.9 CCF39651.1 - 1.6 8.5 5.8 2.3 8.0 0.4 3.5 3 0 0 3 3 3 0 Putative zinc-finger domain RRS1 PF04939.12 CCF39653.1 - 0.43 10.4 1.2 0.74 9.7 1.2 1.3 1 0 0 1 1 1 0 Ribosome biogenesis regulatory protein (RRS1) Fungal_trans PF04082.18 CCF39655.1 - 8.7e-21 74.1 0.8 2.6e-20 72.6 0.1 2.0 2 0 0 2 2 2 1 Fungal specific transcription factor domain TFIIA PF03153.13 CCF39655.1 - 1.8 8.5 11.9 2.7 7.9 11.9 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit GDPD PF03009.17 CCF39656.1 - 3.4e-09 36.8 0.0 4.7e-09 36.3 0.0 1.2 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family GDPD_2 PF13653.6 CCF39656.1 - 2.3e-06 27.8 0.9 4.1e-06 27.1 0.9 1.4 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family GDPD PF03009.17 CCF39657.1 - 1.4e-16 61.0 0.0 1.4e-16 61.0 0.0 1.0 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family MFS_1 PF07690.16 CCF39658.1 - 3.9e-28 98.4 32.7 3.9e-28 98.4 32.7 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily DUF3377 PF11857.8 CCF39658.1 - 3.6 7.6 4.7 7.9 6.5 1.7 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3377) Fungal_trans PF04082.18 CCF39661.1 - 5.3e-06 25.6 0.1 9.7e-06 24.8 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain NAD_binding_11 PF14833.6 CCF39663.1 - 1.5e-67 225.4 1.4 8.8e-35 119.6 0.1 2.5 2 0 0 2 2 2 2 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase NAD_binding_2 PF03446.15 CCF39663.1 - 2.6e-67 225.9 1.5 1.3e-34 119.7 1.3 2.8 2 0 0 2 2 2 2 NAD binding domain of 6-phosphogluconate dehydrogenase SBD_N PF07005.11 CCF39663.1 - 1e-59 202.0 0.0 2.8e-59 200.6 0.0 1.8 1 0 0 1 1 1 1 Sugar-binding N-terminal domain NBD_C PF17042.5 CCF39663.1 - 4.3e-44 151.0 1.3 4.3e-44 151.0 1.3 2.3 2 0 0 2 2 2 1 Nucleotide-binding C-terminal domain 2-Hacid_dh_C PF02826.19 CCF39663.1 - 7.1e-11 41.8 0.0 7.2e-06 25.5 0.0 2.4 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.17 CCF39663.1 - 1e-10 42.1 3.4 0.00024 21.6 0.5 5.0 4 2 2 6 6 6 2 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.18 CCF39663.1 - 5.6e-06 26.4 2.2 0.0011 18.8 0.7 2.4 2 0 0 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ApbA PF02558.16 CCF39663.1 - 0.00044 19.9 0.4 0.1 12.2 0.2 2.8 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA UDPG_MGDP_dh_C PF03720.15 CCF39663.1 - 0.0091 16.4 0.0 2.7 8.5 0.0 2.8 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain UDPG_MGDP_dh PF00984.19 CCF39663.1 - 0.019 15.2 0.5 12 6.2 0.0 3.3 3 1 0 3 3 3 0 UDP-glucose/GDP-mannose dehydrogenase family, central domain Rossmann-like PF10727.9 CCF39663.1 - 0.027 14.3 1.3 0.091 12.6 0.6 2.3 2 0 0 2 2 2 0 Rossmann-like domain UDPG_MGDP_dh_N PF03721.14 CCF39663.1 - 0.054 13.1 0.1 22 4.6 0.1 3.4 2 1 1 3 3 3 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NUP214 PF16755.5 CCF39664.1 - 2.1e-06 27.2 0.0 7.7e-06 25.4 0.0 1.8 1 1 0 1 1 1 1 Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 ANAPC4_WD40 PF12894.7 CCF39664.1 - 0.00013 22.2 0.0 0.0039 17.5 0.1 2.6 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CCF39664.1 - 0.22 12.5 1.0 0.6 11.1 0.0 2.3 2 0 0 2 2 2 0 WD domain, G-beta repeat Proteasome PF00227.26 CCF39665.1 - 9.9e-48 162.2 0.1 1.2e-47 161.9 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.8 CCF39665.1 - 1.2e-12 47.0 0.1 1.2e-12 47.0 0.1 1.9 3 0 0 3 3 3 1 Proteasome beta subunits C terminal Sel1 PF08238.12 CCF39666.1 - 3.3e-10 40.3 8.1 0.0051 17.4 0.1 3.7 3 0 0 3 3 3 3 Sel1 repeat adh_short_C2 PF13561.6 CCF39669.1 - 1.6e-46 158.7 0.5 8.7e-42 143.3 0.0 2.1 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF39669.1 - 2.6e-43 147.8 0.1 3.5e-43 147.4 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF39669.1 - 2.9e-15 56.7 0.1 4e-15 56.2 0.1 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF39669.1 - 0.00032 20.2 0.1 0.0035 16.9 0.1 2.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Yae1_N PF09811.9 CCF39670.1 - 3.8e-09 36.1 4.9 5.6e-09 35.6 4.9 1.3 1 0 0 1 1 1 1 Essential protein Yae1, N terminal Ribosomal_60s PF00428.19 CCF39670.1 - 0.071 13.7 4.7 1.5 9.5 0.6 2.1 2 0 0 2 2 2 0 60s Acidic ribosomal protein Trns_repr_metal PF02583.17 CCF39670.1 - 0.1 13.0 0.0 0.19 12.1 0.0 1.4 1 0 0 1 1 1 0 Metal-sensitive transcriptional repressor His_Phos_2 PF00328.22 CCF39672.1 - 0.00022 20.7 0.5 0.047 13.0 0.0 2.7 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 2) PDGLE PF13190.6 CCF39672.1 - 0.022 14.7 0.1 0.071 13.0 0.1 1.9 1 0 0 1 1 1 0 PDGLE domain DUF575 PF04746.12 CCF39672.1 - 0.12 12.6 0.5 0.2 11.9 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF575) Git3 PF11710.8 CCF39673.1 - 2.1e-18 66.9 12.7 4.1e-18 65.9 12.7 1.5 1 1 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 GPR_Gpa2_C PF11970.8 CCF39673.1 - 6.8e-09 35.7 2.0 1.1e-08 35.1 0.2 2.3 2 0 0 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 C-term Cutinase PF01083.22 CCF39674.1 - 1.5e-49 168.4 3.4 1.8e-49 168.1 3.4 1.0 1 0 0 1 1 1 1 Cutinase PE-PPE PF08237.11 CCF39674.1 - 0.00059 19.5 0.2 0.0011 18.6 0.2 1.5 1 0 0 1 1 1 1 PE-PPE domain VirJ PF06057.11 CCF39674.1 - 0.005 16.7 0.0 0.008 16.1 0.0 1.3 1 0 0 1 1 1 1 Bacterial virulence protein (VirJ) Abhydrolase_3 PF07859.13 CCF39674.1 - 0.011 15.6 0.3 0.018 14.9 0.3 1.3 1 1 0 1 1 1 0 alpha/beta hydrolase fold Amidase PF01425.21 CCF39676.1 - 5.4e-29 101.4 0.0 8.6e-29 100.8 0.0 1.2 1 0 0 1 1 1 1 Amidase UDG PF03167.19 CCF39679.1 - 6.6e-20 71.7 0.0 1.3e-19 70.7 0.0 1.5 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily POR_N PF01855.19 CCF39679.1 - 0.23 11.2 0.1 0.35 10.6 0.1 1.2 1 0 0 1 1 1 0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg Aldedh PF00171.22 CCF39681.1 - 8.8e-31 106.9 0.2 9.6e-31 106.8 0.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family tRNA-synt_2b PF00587.25 CCF39682.1 - 5.5e-36 124.2 0.0 3.2e-32 111.9 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 CCF39682.1 - 5.6e-11 42.5 0.1 1.9e-10 40.8 0.1 1.9 2 0 0 2 2 2 1 Anticodon binding domain EIIBC-GUT_C PF07663.11 CCF39682.1 - 0.12 12.6 0.0 0.43 10.8 0.0 1.8 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II C-terminus HLH PF00010.26 CCF39683.1 - 6.7e-09 35.6 0.0 1.1e-08 34.9 0.0 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Umbravirus_LDM PF04817.12 CCF39683.1 - 0.0094 15.3 0.1 0.011 15.1 0.1 1.1 1 0 0 1 1 1 1 Umbravirus long distance movement (LDM) family DUF3006 PF11213.8 CCF39683.1 - 2 8.7 5.8 25 5.2 0.4 2.9 2 2 1 3 3 3 0 Protein of unknown function (DUF3006) Methyltransf_23 PF13489.6 CCF39684.1 - 7.2e-20 71.5 0.0 1.1e-19 70.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF39684.1 - 1e-09 39.0 0.0 2.1e-09 37.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF39684.1 - 1.2e-06 29.0 0.0 2.2e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF39684.1 - 4.4e-05 24.1 0.0 0.00024 21.8 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF39684.1 - 6.2e-05 22.8 0.0 0.00043 20.1 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.9 CCF39684.1 - 0.018 14.8 0.0 0.029 14.1 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase MTS PF05175.14 CCF39684.1 - 0.039 13.5 0.0 0.071 12.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_2 PF00891.18 CCF39684.1 - 0.097 12.0 0.0 0.71 9.1 0.0 2.2 2 1 0 2 2 2 0 O-methyltransferase domain Peptidase_M13_N PF05649.13 CCF39685.1 - 0.0018 18.0 0.1 0.0021 17.8 0.1 1.1 1 0 0 1 1 1 1 Peptidase family M13 Methyltransf_10 PF05971.12 CCF39686.1 - 4.2e-66 223.3 0.0 5.6e-66 222.9 0.0 1.1 1 0 0 1 1 1 1 RNA methyltransferase MTS PF05175.14 CCF39686.1 - 3.4e-05 23.5 0.0 6.2e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 CCF39686.1 - 0.0016 17.9 0.0 0.0082 15.6 0.0 1.9 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.7 CCF39686.1 - 0.0019 18.2 0.0 0.0033 17.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.18 CCF39686.1 - 0.022 14.4 0.0 0.041 13.6 0.0 1.3 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 Methyltransf_25 PF13649.6 CCF39686.1 - 0.023 15.4 0.0 0.069 13.9 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_11 PF08241.12 CCF39686.1 - 0.14 12.9 0.0 0.3 11.7 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain PhoLip_ATPase_C PF16212.5 CCF39687.1 - 9.8e-76 254.8 26.4 9.8e-76 254.8 26.4 2.6 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal Cation_ATPase PF13246.6 CCF39687.1 - 1.2e-11 44.5 0.0 5.5e-11 42.4 0.0 2.0 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 CCF39687.1 - 9e-11 42.5 2.3 4e-07 30.5 0.4 3.0 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 CCF39687.1 - 0.00014 21.5 0.1 0.00063 19.3 0.0 2.1 2 0 0 2 2 2 1 E1-E2 ATPase PhoLip_ATPase_N PF16209.5 CCF39687.1 - 0.00022 20.8 1.3 0.00081 19.0 1.3 1.9 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Hydrolase_3 PF08282.12 CCF39687.1 - 0.011 15.5 0.6 0.022 14.5 0.6 1.4 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Aldedh PF00171.22 CCF39688.1 - 9.2e-115 383.8 0.0 1.1e-114 383.5 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DEAD PF00270.29 CCF39689.1 - 1.5e-41 142.1 0.0 2.4e-41 141.4 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF39689.1 - 4.5e-27 94.6 0.0 1.4e-26 93.0 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 CCF39689.1 - 0.011 14.5 0.0 0.016 13.9 0.0 1.1 1 0 0 1 1 1 0 SNF2 family N-terminal domain K_channel_TID PF07941.11 CCF39689.1 - 5.7 7.5 13.5 14 6.2 13.5 1.8 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain Ipi1_N PF12333.8 CCF39690.1 - 1.4e-30 105.9 1.1 4.5e-30 104.2 0.0 2.1 2 0 0 2 2 2 1 Rix1 complex component involved in 60S ribosome maturation TPR_20 PF14561.6 CCF39690.1 - 0.034 14.5 0.1 0.077 13.3 0.1 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat Sugar_tr PF00083.24 CCF39691.1 - 5.1e-70 236.6 16.8 5.9e-70 236.4 16.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF39691.1 - 7e-14 51.5 25.1 7e-14 51.5 25.1 2.3 1 1 2 3 3 3 1 Major Facilitator Superfamily MFS_1_like PF12832.7 CCF39691.1 - 0.0082 15.0 7.7 0.5 9.2 0.2 2.8 1 1 0 2 2 2 2 MFS_1 like family FMO-like PF00743.19 CCF39692.1 - 1.1e-31 109.8 0.0 1.4e-31 109.6 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 CCF39692.1 - 9.4e-08 31.7 0.0 1e-07 31.5 0.0 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CCF39692.1 - 5.1e-07 29.8 0.0 1e-05 25.6 0.0 2.0 1 1 0 1 1 1 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 CCF39692.1 - 5.3e-07 29.8 0.1 8.7e-07 29.1 0.1 1.5 1 1 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CCF39692.1 - 2.4e-06 27.0 0.0 4.9e-06 26.0 0.0 1.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CCF39692.1 - 2.6e-06 26.8 0.4 6.4e-05 22.3 0.1 2.0 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 CCF39692.1 - 0.0013 18.4 0.0 0.8 9.2 0.0 2.2 2 1 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox PF00070.27 CCF39692.1 - 0.0027 18.2 0.0 0.089 13.4 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Occludin_ELL PF07303.13 CCF39692.1 - 0.019 15.7 0.9 0.026 15.2 0.9 1.2 1 0 0 1 1 1 0 Occludin homology domain Amino_oxidase PF01593.24 CCF39692.1 - 0.023 14.0 0.0 0.53 9.5 0.0 2.0 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase FAD_binding_3 PF01494.19 CCF39692.1 - 0.026 13.8 0.3 0.15 11.3 0.1 1.9 2 0 0 2 2 2 0 FAD binding domain IlvN PF07991.12 CCF39692.1 - 0.038 13.6 0.0 0.054 13.1 0.0 1.3 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain HI0933_like PF03486.14 CCF39692.1 - 0.17 10.6 0.0 0.49 9.0 0.1 1.6 2 0 0 2 2 2 0 HI0933-like protein adh_short_C2 PF13561.6 CCF39693.1 - 1.9e-50 171.6 0.1 2.6e-50 171.2 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF39693.1 - 7.9e-44 149.5 0.2 1.1e-43 149.0 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF39693.1 - 6.6e-07 29.4 0.0 1.1e-06 28.7 0.0 1.4 1 0 0 1 1 1 1 KR domain DUF1614 PF07758.11 CCF39693.1 - 0.084 12.9 0.0 0.13 12.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1614) RPN2_C PF18004.1 CCF39694.1 - 2e-48 164.3 4.3 6.6e-48 162.6 4.7 1.7 2 0 0 2 2 2 1 26S proteasome regulatory subunit RPN2 C-terminal domain PC_rep PF01851.22 CCF39694.1 - 1.3e-40 135.8 20.5 9.8e-09 35.2 0.0 8.3 8 0 0 8 8 8 7 Proteasome/cyclosome repeat HEAT_2 PF13646.6 CCF39694.1 - 8.1e-22 77.4 0.0 8.4e-15 54.9 0.0 5.7 4 1 2 6 6 6 2 HEAT repeats HEAT PF02985.22 CCF39694.1 - 2.8e-07 30.2 0.8 2.5 8.6 0.0 6.5 6 0 0 6 6 6 2 HEAT repeat HEAT_EZ PF13513.6 CCF39694.1 - 0.0001 22.7 0.1 0.017 15.6 0.0 4.3 3 1 1 4 4 4 2 HEAT-like repeat Cnd1 PF12717.7 CCF39694.1 - 0.0054 16.8 0.2 2.4 8.2 0.0 3.5 2 1 1 3 3 3 1 non-SMC mitotic condensation complex subunit 1 TPR_19 PF14559.6 CCF39694.1 - 0.067 13.7 0.8 19 5.9 1.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat ILVD_EDD PF00920.21 CCF39695.1 - 5.7e-41 140.7 0.2 6.4e-41 140.5 0.2 1.0 1 0 0 1 1 1 1 Dehydratase family Glyco_transf_15 PF01793.16 CCF39696.1 - 1.4e-90 303.8 6.2 1.8e-89 300.2 6.2 2.0 1 1 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase DUF3328 PF11807.8 CCF39697.1 - 1.4e-19 70.8 8.0 1.7e-19 70.5 8.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) stn_TNFRSF12A PF12191.8 CCF39699.1 - 0.2 11.9 0.4 0.35 11.1 0.4 1.4 1 0 0 1 1 1 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain Hamartin PF04388.12 CCF39699.1 - 1.9 7.1 10.6 2 7.0 10.6 1.1 1 0 0 1 1 1 0 Hamartin protein Abhydro_lipase PF04083.16 CCF39700.1 - 1.7e-10 40.4 0.0 3e-10 39.5 0.0 1.4 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.20 CCF39700.1 - 0.033 13.8 0.0 0.059 13.0 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold SurE PF01975.17 CCF39701.1 - 4.8e-27 95.0 0.0 6.9e-27 94.5 0.0 1.2 1 0 0 1 1 1 1 Survival protein SurE DUF5397 PF17375.2 CCF39702.1 - 0.11 12.3 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5397) Carn_acyltransf PF00755.20 CCF39705.1 - 5e-143 477.8 0.1 6e-143 477.6 0.1 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase SWIRM PF04433.17 CCF39706.1 - 3.5e-31 107.4 0.1 7.5e-31 106.3 0.1 1.6 1 0 0 1 1 1 1 SWIRM domain SWIRM-assoc_1 PF16495.5 CCF39706.1 - 9.6e-30 102.4 5.9 2.1e-29 101.3 5.9 1.6 1 0 0 1 1 1 1 SWIRM-associated region 1 Myb_DNA-binding PF00249.31 CCF39706.1 - 4.6e-10 39.5 0.0 1.2e-09 38.2 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CCF39706.1 - 6.3e-06 26.3 0.0 1.5e-05 25.2 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain ZZ PF00569.17 CCF39706.1 - 0.024 14.5 3.9 0.049 13.5 3.9 1.5 1 0 0 1 1 1 0 Zinc finger, ZZ type DUF3439 PF11921.8 CCF39706.1 - 0.068 13.1 0.6 0.16 12.0 0.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) SANT_DAMP1_like PF16282.5 CCF39706.1 - 0.14 12.4 0.0 0.3 11.3 0.0 1.5 1 0 0 1 1 1 0 SANT/Myb-like domain of DAMP1 ETF PF01012.21 CCF39707.1 - 1.8e-43 148.6 1.3 2.9e-43 147.9 1.3 1.3 1 0 0 1 1 1 1 Electron transfer flavoprotein domain ETF_alpha PF00766.19 CCF39707.1 - 3.1e-34 116.9 1.3 5.7e-34 116.0 0.3 2.0 2 0 0 2 2 2 1 Electron transfer flavoprotein FAD-binding domain Pyr_redox_2 PF07992.14 CCF39708.1 - 9.8e-10 38.1 0.0 1.1e-08 34.7 0.0 2.2 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCF39708.1 - 0.023 14.9 0.0 0.073 13.3 0.0 1.8 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 CCF39708.1 - 0.16 10.6 0.0 0.26 10.0 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein XRN_M PF17846.1 CCF39710.1 - 3.8e-135 451.3 0.1 1.4e-134 449.4 0.0 1.9 2 1 0 2 2 2 1 Xrn1 helical domain XRN_N PF03159.18 CCF39710.1 - 7.8e-99 330.0 0.0 1.8e-98 328.8 0.0 1.6 2 0 0 2 2 2 1 XRN 5'-3' exonuclease N-terminus zf-CCHC_2 PF13696.6 CCF39710.1 - 0.12 12.2 2.2 0.29 11.0 2.2 1.6 1 0 0 1 1 1 0 Zinc knuckle NAD_binding_8 PF13450.6 CCF39711.1 - 2.5e-05 24.4 0.0 3.1e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 CCF39711.1 - 0.00036 19.9 0.0 0.00039 19.8 0.0 1.0 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 CCF39711.1 - 0.0018 18.0 0.0 0.0018 17.9 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 CCF39711.1 - 0.021 13.9 0.0 0.022 13.8 0.0 1.1 1 0 0 1 1 1 0 Lycopene cyclase protein Pyr_redox_2 PF07992.14 CCF39711.1 - 0.024 13.9 0.0 0.027 13.7 0.0 1.0 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CCF39711.1 - 0.048 12.9 0.0 0.056 12.7 0.0 1.1 1 0 0 1 1 1 0 Thi4 family NAD_binding_9 PF13454.6 CCF39711.1 - 0.048 13.6 0.0 0.055 13.5 0.0 1.2 1 0 0 1 1 1 0 FAD-NAD(P)-binding HI0933_like PF03486.14 CCF39711.1 - 0.06 12.0 0.0 0.066 11.9 0.0 1.1 1 0 0 1 1 1 0 HI0933-like protein Pyr_redox PF00070.27 CCF39711.1 - 0.22 12.1 0.0 0.26 11.9 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Lactamase_B_3 PF13483.6 CCF39714.1 - 1.3e-07 31.6 0.0 2.4e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_2 PF12706.7 CCF39714.1 - 2.5e-06 27.1 0.1 4.1e-06 26.5 0.1 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain DUF962 PF06127.11 CCF39715.1 - 8.3e-27 93.1 0.0 1.5e-26 92.3 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF962) Promethin PF16015.5 CCF39715.1 - 8.6 6.3 9.3 0.38 10.7 3.6 1.7 2 0 0 2 2 2 0 Promethin SHS2_Rpb7-N PF03876.17 CCF39716.1 - 1.6e-15 57.2 0.0 2.5e-15 56.6 0.0 1.3 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.23 CCF39716.1 - 9.7e-12 45.1 0.0 1.6e-11 44.3 0.0 1.3 1 0 0 1 1 1 1 S1 RNA binding domain Fungal_trans_2 PF11951.8 CCF39717.1 - 1.6e-68 231.3 2.6 2.5e-68 230.6 2.6 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF39717.1 - 7.3e-09 35.6 6.2 1.6e-08 34.5 6.2 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain OPT PF03169.15 CCF39718.1 - 1.5e-160 535.8 40.5 1.8e-160 535.6 40.5 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Ribosomal_S25 PF03297.15 CCF39719.1 - 7.5e-39 132.0 3.9 8.2e-39 131.9 3.9 1.0 1 0 0 1 1 1 1 S25 ribosomal protein HTH_24 PF13412.6 CCF39719.1 - 0.0034 16.9 0.2 0.0053 16.3 0.2 1.3 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding MarR_2 PF12802.7 CCF39719.1 - 0.012 15.5 0.0 0.014 15.2 0.0 1.2 1 0 0 1 1 1 0 MarR family HTH_DeoR PF08220.12 CCF39719.1 - 0.016 14.9 0.1 0.031 14.0 0.1 1.5 1 1 1 2 2 2 0 DeoR-like helix-turn-helix domain Rrf2 PF02082.20 CCF39719.1 - 0.1 12.9 0.0 0.15 12.4 0.0 1.2 1 0 0 1 1 1 0 Transcriptional regulator FtsK_gamma PF09397.10 CCF39719.1 - 0.12 12.2 0.0 0.21 11.4 0.0 1.5 1 1 0 1 1 1 0 Ftsk gamma domain Glyco_hydro_61 PF03443.14 CCF39722.1 - 4e-47 160.8 0.0 5.3e-47 160.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 Gin PF10764.9 CCF39723.1 - 0.028 14.4 0.2 0.046 13.7 0.2 1.3 1 0 0 1 1 1 0 Inhibitor of sigma-G Gin Peptidase_M43 PF05572.13 CCF39724.1 - 5.3e-14 52.4 0.4 8.7e-14 51.7 0.4 1.3 1 0 0 1 1 1 1 Pregnancy-associated plasma protein-A Reprolysin_3 PF13582.6 CCF39724.1 - 2.1e-06 28.2 0.1 3.3e-06 27.6 0.1 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 CCF39724.1 - 3.3e-06 27.4 0.2 4.8e-06 26.9 0.2 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12 Peptidase_M10 PF00413.24 CCF39724.1 - 3e-05 23.9 0.0 4.9e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Matrixin Reprolysin_2 PF13574.6 CCF39724.1 - 0.0082 16.1 0.1 0.013 15.5 0.1 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 CCF39724.1 - 0.0089 15.7 1.9 0.014 15.0 1.9 1.4 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M66 PF10462.9 CCF39724.1 - 0.056 12.4 0.8 0.071 12.0 0.8 1.2 1 0 0 1 1 1 0 Peptidase M66 DUF4953 PF16313.5 CCF39724.1 - 0.059 12.6 0.3 0.14 11.4 0.3 1.5 1 0 0 1 1 1 0 Met-zincin Ecm33 PF12454.8 CCF39724.1 - 0.15 12.3 0.3 0.41 10.8 0.2 1.8 2 0 0 2 2 2 0 GPI-anchored cell wall organization protein Peptidase_M57 PF12388.8 CCF39724.1 - 0.15 11.6 2.3 0.26 10.9 1.5 1.7 1 1 1 2 2 2 0 Dual-action HEIGH metallo-peptidase p450 PF00067.22 CCF39725.1 - 1.2e-54 185.8 0.0 1.6e-54 185.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 GRDP-like PF07173.12 CCF39726.1 - 2e-20 73.9 0.1 2e-16 60.9 0.0 2.6 2 1 0 2 2 2 2 Glycine-rich domain-containing protein-like Kelch_5 PF13854.6 CCF39727.1 - 6e-10 38.9 1.4 4.6e-07 29.7 0.0 3.2 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 CCF39727.1 - 0.048 13.7 4.1 0.21 11.6 0.5 3.2 3 1 0 3 3 3 0 Galactose oxidase, central domain Kelch_2 PF07646.15 CCF39727.1 - 0.087 12.8 2.2 1.2 9.3 0.2 3.0 3 1 0 3 3 3 0 Kelch motif DUF4701 PF15773.5 CCF39728.1 - 0.12 11.4 0.0 0.12 11.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4701) ADH_N PF08240.12 CCF39729.1 - 1.7e-27 95.4 0.3 3.5e-27 94.4 0.3 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCF39729.1 - 1.9e-22 79.6 1.0 3.7e-22 78.7 1.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 CCF39729.1 - 3.3e-09 36.6 0.3 5.3e-09 35.9 0.3 1.3 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 CCF39729.1 - 0.0014 19.7 0.1 0.004 18.2 0.1 1.8 1 1 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 CCF39729.1 - 0.054 12.8 1.3 0.089 12.1 1.3 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 CCF39729.1 - 0.091 12.1 0.1 0.23 10.8 0.1 1.6 1 1 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AdoHcyase_NAD PF00670.21 CCF39729.1 - 0.11 12.6 0.6 0.29 11.2 0.5 1.8 2 0 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Pyr_redox_3 PF13738.6 CCF39729.1 - 0.15 11.3 0.2 0.24 10.6 0.2 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase MFS_1 PF07690.16 CCF39730.1 - 1.3e-30 106.6 71.7 2.2e-20 72.9 36.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Cupin_2 PF07883.11 CCF39731.1 - 8.6e-15 54.2 0.1 1.8e-14 53.2 0.0 1.5 2 0 0 2 2 2 1 Cupin domain Cupin_1 PF00190.22 CCF39731.1 - 5.2e-06 26.1 0.0 6.1e-06 25.9 0.0 1.1 1 0 0 1 1 1 1 Cupin AraC_binding PF02311.19 CCF39731.1 - 0.00022 21.1 0.0 0.0003 20.7 0.0 1.2 1 0 0 1 1 1 1 AraC-like ligand binding domain MannoseP_isomer PF01050.18 CCF39731.1 - 0.0019 18.1 0.0 0.0023 17.9 0.0 1.1 1 0 0 1 1 1 1 Mannose-6-phosphate isomerase CENP-C_C PF11699.8 CCF39731.1 - 0.0041 17.3 0.0 0.0057 16.8 0.0 1.2 1 0 0 1 1 1 1 Mif2/CENP-C like Cupin_6 PF12852.7 CCF39731.1 - 0.017 14.9 0.1 0.055 13.2 0.0 1.7 2 0 0 2 2 2 0 Cupin PAS_9 PF13426.7 CCF39732.1 - 1.3e-15 57.5 0.0 1.9e-15 57.0 0.0 1.1 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 CCF39732.1 - 0.0001 22.3 0.0 0.0029 17.6 0.0 2.1 1 1 0 1 1 1 1 PAS fold PAS_3 PF08447.12 CCF39732.1 - 0.14 12.5 0.0 0.81 10.0 0.0 2.0 1 1 0 1 1 1 0 PAS fold BLM10_mid PF16507.5 CCF39733.1 - 1.3e-67 228.6 0.0 5.8e-67 226.5 0.0 2.1 3 0 0 3 3 3 1 Proteasome-substrate-size regulator, mid region DUF3437 PF11919.8 CCF39733.1 - 2.1e-29 101.2 0.0 1e-28 99.0 0.0 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF3437) HEAT PF02985.22 CCF39733.1 - 0.019 15.2 2.5 5.7 7.5 0.1 4.8 4 0 0 4 4 4 0 HEAT repeat Methyltransf_11 PF08241.12 CCF39734.1 - 3.7e-13 49.9 0.0 8.7e-13 48.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF39734.1 - 1.7e-05 25.4 0.0 4.1e-05 24.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCF39734.1 - 0.03 13.7 0.0 0.05 12.9 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 CCF39734.1 - 0.036 13.9 0.0 0.079 12.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 CCF39734.1 - 0.042 13.7 0.0 0.085 12.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 CCF39734.1 - 0.15 12.8 0.0 0.35 11.7 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_8 PF05148.15 CCF39734.1 - 0.2 11.5 0.0 0.35 10.7 0.0 1.3 1 0 0 1 1 1 0 Hypothetical methyltransferase Aspzincin_M35 PF14521.6 CCF39735.1 - 3.6e-05 24.3 0.8 0.002 18.7 0.8 2.7 1 1 0 1 1 1 1 Lysine-specific metallo-endopeptidase SOBP PF15279.6 CCF39735.1 - 9e-05 23.2 9.7 9e-05 23.2 9.7 2.0 2 0 0 2 2 2 1 Sine oculis-binding protein RAM PF15320.6 CCF39735.1 - 0.099 13.2 1.8 0.24 12.0 1.8 1.6 1 0 0 1 1 1 0 mRNA cap methylation, RNMT-activating mini protein Hydin_ADK PF17213.3 CCF39735.1 - 0.82 9.9 4.8 0.46 10.7 0.1 2.2 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain DGF-1_C PF11040.8 CCF39735.1 - 4.3 7.4 8.9 1.5 8.9 0.1 2.8 2 0 0 2 2 2 0 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus PhyH PF05721.13 CCF39737.1 - 7.3e-21 75.4 0.1 9.5e-21 75.0 0.1 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Lon_C PF05362.13 CCF39738.1 - 4e-64 215.9 0.0 7e-64 215.1 0.0 1.4 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain LON_substr_bdg PF02190.16 CCF39738.1 - 3.7e-34 118.4 0.2 1.1e-33 116.9 0.0 2.0 2 1 0 2 2 1 1 ATP-dependent protease La (LON) substrate-binding domain AAA PF00004.29 CCF39738.1 - 6.6e-22 78.4 0.0 2.2e-21 76.7 0.0 2.0 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ChlI PF13541.6 CCF39738.1 - 5.7e-07 29.4 0.1 2.5e-06 27.3 0.0 2.1 2 0 0 2 2 2 1 Subunit ChlI of Mg-chelatase AAA_2 PF07724.14 CCF39738.1 - 6.9e-07 29.5 0.0 3.5e-06 27.3 0.0 2.1 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 CCF39738.1 - 1.2e-06 28.6 0.0 3e-06 27.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 CCF39738.1 - 2.9e-05 24.4 0.0 0.00047 20.4 0.0 2.7 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 CCF39738.1 - 0.00012 21.8 0.0 0.00097 18.9 0.0 2.5 4 0 0 4 4 3 1 Holliday junction DNA helicase RuvB P-loop domain AAA_PrkA PF08298.11 CCF39738.1 - 0.00014 20.9 0.0 0.00029 19.9 0.0 1.4 1 0 0 1 1 1 1 PrkA AAA domain AAA_18 PF13238.6 CCF39738.1 - 0.00015 22.3 0.1 0.014 15.9 0.0 3.3 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.6 CCF39738.1 - 0.00022 21.7 0.1 0.002 18.5 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain IstB_IS21 PF01695.17 CCF39738.1 - 0.0041 16.9 0.0 0.05 13.3 0.0 2.3 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_14 PF13173.6 CCF39738.1 - 0.0071 16.4 0.0 0.03 14.4 0.0 2.0 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 CCF39738.1 - 0.024 15.0 0.0 0.1 13.0 0.0 2.2 1 0 0 1 1 1 0 RNA helicase RsgA_GTPase PF03193.16 CCF39738.1 - 0.038 13.9 0.0 0.11 12.4 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase AAA_30 PF13604.6 CCF39738.1 - 0.052 13.3 0.1 0.14 11.8 0.0 1.7 2 0 0 2 2 1 0 AAA domain NTPase_1 PF03266.15 CCF39738.1 - 0.061 13.2 0.3 1.1 9.1 0.0 2.6 1 1 1 2 2 2 0 NTPase DNTTIP1_dimer PF18192.1 CCF39738.1 - 0.08 13.3 0.3 1.5 9.2 0.1 2.9 2 0 0 2 2 2 0 DNTTIP1 dimerisation domain AAA_7 PF12775.7 CCF39738.1 - 0.088 12.3 1.1 0.18 11.3 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_28 PF13521.6 CCF39738.1 - 0.092 13.0 0.5 4.9 7.4 0.0 3.1 3 0 0 3 3 3 0 AAA domain MMR_HSR1 PF01926.23 CCF39738.1 - 0.51 10.4 2.1 8.9 6.4 0.0 3.0 3 0 0 3 3 3 0 50S ribosome-binding GTPase ClpB_D2-small PF10431.9 CCF39738.1 - 0.68 10.0 5.5 0.24 11.5 0.6 2.6 2 0 0 2 2 2 0 C-terminal, D2-small domain, of ClpB protein ABC_tran PF00005.27 CCF39738.1 - 1.3 9.5 5.3 0.72 10.4 0.1 2.9 3 0 0 3 3 3 0 ABC transporter TFB6 PF17110.5 CCF39739.1 - 0.79 9.5 3.8 0.76 9.5 0.7 1.9 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH Avl9 PF09794.9 CCF39740.1 - 1.6e-143 478.0 0.0 2e-143 477.7 0.0 1.1 1 0 0 1 1 1 1 Transport protein Avl9 DUF2347 PF09804.9 CCF39740.1 - 1.7e-06 27.9 1.0 6e-05 22.8 0.1 3.2 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2347) SPA PF08616.10 CCF39740.1 - 3.5e-06 26.9 0.1 0.00026 20.9 0.0 2.3 2 0 0 2 2 2 2 Stabilization of polarity axis AAA PF00004.29 CCF39744.1 - 5.1e-15 56.1 0.0 1e-14 55.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CCF39744.1 - 0.0016 18.5 0.0 0.0037 17.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 CCF39744.1 - 0.0036 17.6 0.3 0.17 12.2 0.1 2.5 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 CCF39744.1 - 0.0056 17.1 0.0 0.015 15.7 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_24 PF13479.6 CCF39744.1 - 0.066 12.9 0.0 0.21 11.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain CPT PF07931.12 CCF39744.1 - 0.11 12.3 0.0 1.1 9.0 0.0 2.2 1 1 1 2 2 2 0 Chloramphenicol phosphotransferase-like protein RuvB_N PF05496.12 CCF39744.1 - 0.15 11.8 0.0 0.3 10.8 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain DUF1479 PF07350.12 CCF39745.1 - 4e-23 81.9 0.0 5.1e-23 81.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1479) FA_desaturase PF00487.24 CCF39745.1 - 0.0093 15.8 0.2 0.012 15.5 0.2 1.1 1 0 0 1 1 1 1 Fatty acid desaturase OPT PF03169.15 CCF39751.1 - 3.7e-39 134.9 0.6 4.2e-39 134.7 0.6 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein PI3K_1B_p101 PF10486.9 CCF39754.1 - 1.8 6.3 5.4 2 6.1 5.4 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Rad1 PF02144.16 CCF39755.1 - 3.6e-71 239.5 0.0 4.2e-71 239.2 0.0 1.0 1 0 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 Bromodomain PF00439.25 CCF39756.1 - 1.5e-24 85.9 0.6 3.2e-24 84.8 0.6 1.6 1 0 0 1 1 1 1 Bromodomain Acetyltransf_1 PF00583.25 CCF39756.1 - 6.3e-08 32.9 0.0 1.1e-07 32.1 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CCF39756.1 - 6.1e-07 29.4 0.2 1.5e-06 28.1 0.2 1.7 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CCF39756.1 - 0.00032 21.1 0.4 0.00061 20.2 0.1 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CCF39756.1 - 0.1 12.6 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 FR47-like protein Acetyltransf_3 PF13302.7 CCF39756.1 - 0.12 13.0 0.0 5.3 7.7 0.0 2.3 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain DUF1656 PF07869.12 CCF39757.1 - 0.33 11.0 5.1 0.18 11.8 2.8 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1656) Sugar_tr PF00083.24 CCF39758.1 - 1.3e-36 126.5 31.3 4.6e-25 88.4 13.2 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 CCF39758.1 - 6.1e-20 71.4 39.5 4.3e-10 39.0 24.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3139 PF11337.8 CCF39758.1 - 0.015 16.0 1.5 4.7 7.9 0.2 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3139) Phage_holin_2_4 PF16082.5 CCF39758.1 - 0.22 11.3 3.1 0.3 10.9 0.1 2.7 2 1 0 2 2 2 0 Bacteriophage holin family, superfamily II-like PhoD PF09423.10 CCF39759.1 - 4.2e-40 137.8 5.0 1.5e-39 136.0 5.0 1.8 1 1 0 1 1 1 1 PhoD-like phosphatase Pur_ac_phosph_N PF16656.5 CCF39759.1 - 0.033 14.8 0.0 0.14 12.8 0.0 2.1 1 0 0 1 1 1 0 Purple acid Phosphatase, N-terminal domain Phage_lysozyme2 PF18013.1 CCF39760.1 - 0.13 12.2 0.6 0.28 11.2 0.1 1.6 1 1 1 2 2 2 0 Phage tail lysozyme Methyltransf_23 PF13489.6 CCF39761.1 - 9.3e-12 45.1 0.0 1.3e-11 44.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF39761.1 - 5.6e-11 43.0 0.0 2e-10 41.3 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF39761.1 - 5e-09 36.8 0.0 8.7e-09 36.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF39761.1 - 1.4e-08 34.7 0.0 2.8e-08 33.7 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF39761.1 - 5.6e-08 33.3 0.0 1.3e-07 32.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCF39761.1 - 0.00071 19.0 0.0 0.0053 16.1 0.0 2.1 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family FtsJ PF01728.19 CCF39761.1 - 0.0045 17.1 0.2 0.24 11.5 0.0 2.3 1 1 1 2 2 2 1 FtsJ-like methyltransferase CheR PF01739.18 CCF39761.1 - 0.0052 16.3 0.0 0.073 12.5 0.0 2.4 1 1 2 3 3 3 1 CheR methyltransferase, SAM binding domain MetW PF07021.12 CCF39761.1 - 0.0085 15.7 0.0 0.014 15.0 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW NodS PF05401.11 CCF39761.1 - 0.0087 15.7 0.0 0.014 15.0 0.0 1.3 1 0 0 1 1 1 1 Nodulation protein S (NodS) Abhydrolase_6 PF12697.7 CCF39762.1 - 6.9e-10 39.9 1.5 9.2e-10 39.5 1.5 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCF39762.1 - 0.05 12.9 0.1 0.087 12.1 0.1 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Reprolysin_5 PF13688.6 CCF39763.1 - 2.4e-55 187.8 5.8 3.3e-55 187.3 5.8 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_2 PF13574.6 CCF39763.1 - 1.3e-48 165.5 2.0 1.8e-48 165.0 2.0 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 CCF39763.1 - 2.7e-45 154.5 1.6 4.2e-45 153.9 1.6 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.6 CCF39763.1 - 3.9e-12 46.8 0.0 7.7e-12 45.8 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin PF01421.19 CCF39763.1 - 0.00014 21.8 4.3 0.0072 16.2 4.4 3.1 1 1 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease SnoaL_3 PF13474.6 CCF39763.1 - 0.086 13.1 0.1 0.28 11.4 0.1 1.8 2 0 0 2 2 2 0 SnoaL-like domain Peptidase_M66 PF10462.9 CCF39763.1 - 0.12 11.3 0.3 0.18 10.8 0.3 1.3 1 0 0 1 1 1 0 Peptidase M66 Toxin_12 PF07740.12 CCF39764.1 - 0.22 12.3 15.7 0.48 11.1 10.1 2.4 2 0 0 2 2 2 0 Ion channel inhibitory toxin Toxin_21 PF08091.11 CCF39764.1 - 9.3 6.3 21.7 0.83 9.6 11.9 2.4 1 1 1 2 2 2 0 Spider insecticidal peptide NACHT_N PF17100.5 CCF39766.1 - 1.1e-34 120.2 0.0 2.6e-34 119.0 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of NWD NACHT-NTPase NACHT PF05729.12 CCF39766.1 - 1.9e-05 24.6 0.0 0.00015 21.7 0.0 2.3 1 1 1 2 2 2 1 NACHT domain AAA_22 PF13401.6 CCF39766.1 - 0.0012 19.2 0.0 0.0036 17.6 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CCF39766.1 - 0.0026 18.2 0.4 0.0093 16.4 0.3 2.0 1 1 0 1 1 1 1 AAA ATPase domain SLC35F PF06027.12 CCF39767.1 - 1.1e-96 323.9 22.8 1.5e-96 323.5 22.8 1.1 1 0 0 1 1 1 1 Solute carrier family 35 CRT-like PF08627.10 CCF39767.1 - 1.4e-09 37.4 4.6 2.2e-09 36.7 4.6 1.3 1 0 0 1 1 1 1 CRT-like, chloroquine-resistance transporter-like EamA PF00892.20 CCF39767.1 - 3.6e-06 27.2 38.2 0.0022 18.2 10.8 2.2 2 0 0 2 2 2 2 EamA-like transporter family FUSC-like PF12805.7 CCF39767.1 - 0.51 9.4 7.1 0.064 12.3 1.4 2.2 2 1 0 2 2 2 0 FUSC-like inner membrane protein yccS GH131_N PF18271.1 CCF39769.1 - 2e-62 211.2 1.2 2.3e-62 211.0 1.2 1.0 1 0 0 1 1 1 1 Glycoside hydrolase 131 catalytic N-terminal domain Polysacc_lyase PF14099.6 CCF39769.1 - 0.016 15.1 4.0 0.023 14.5 4.0 1.4 1 1 0 1 1 1 0 Polysaccharide lyase PNP_UDP_1 PF01048.20 CCF39770.1 - 3.1e-08 33.2 0.6 0.00021 20.6 0.4 3.3 2 1 1 3 3 3 2 Phosphorylase superfamily NACHT PF05729.12 CCF39770.1 - 9.5e-05 22.4 0.0 0.00021 21.3 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 CCF39770.1 - 0.0021 18.5 2.3 0.014 15.8 0.0 3.3 4 0 0 4 4 4 1 AAA ATPase domain NB-ARC PF00931.22 CCF39770.1 - 0.0022 17.2 0.0 0.077 12.2 0.0 2.4 2 0 0 2 2 2 1 NB-ARC domain AAA_22 PF13401.6 CCF39770.1 - 0.0024 18.1 0.0 0.011 16.0 0.0 2.1 3 0 0 3 3 3 1 AAA domain Sulfotransfer_2 PF03567.14 CCF39770.1 - 0.02 14.8 0.0 0.039 13.8 0.0 1.4 1 0 0 1 1 1 0 Sulfotransferase family Pox_G9-A16 PF03003.16 CCF39771.1 - 0.12 12.1 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 Pox virus entry-fusion-complex G9/A16 BBE PF08031.12 CCF39772.1 - 5.3e-16 58.4 0.6 9.8e-16 57.6 0.6 1.5 1 0 0 1 1 1 1 Berberine and berberine like WD40 PF00400.32 CCF39774.1 - 2e-36 123.3 8.4 2.6e-07 31.2 0.0 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF39774.1 - 7.6e-14 51.8 0.1 0.00069 19.9 0.0 4.5 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 CCF39774.1 - 0.015 14.6 0.0 11 5.2 0.0 3.1 3 1 0 3 3 3 0 WD40-like domain Nucleoporin_N PF08801.11 CCF39774.1 - 0.017 13.9 0.4 9.2 4.9 0.0 3.3 2 1 1 3 3 3 0 Nup133 N terminal like Asp PF00026.23 CCF39775.1 - 1.7e-27 96.7 0.0 5.1e-27 95.1 0.0 1.6 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCF39775.1 - 0.008 16.4 0.1 0.06 13.6 0.0 2.1 1 1 1 2 2 2 1 Xylanase inhibitor N-terminal p450 PF00067.22 CCF39776.1 - 1.7e-51 175.5 0.0 5.2e-37 127.7 0.0 2.7 2 1 0 2 2 2 2 Cytochrome P450 DUF2065 PF09838.9 CCF39776.1 - 0.056 13.5 0.1 0.12 12.5 0.1 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2065) DAHP_synth_1 PF00793.20 CCF39777.1 - 0.1 11.4 0.0 0.14 11.0 0.0 1.1 1 0 0 1 1 1 0 DAHP synthetase I family GST_C_3 PF14497.6 CCF39779.1 - 4.9e-33 113.3 0.0 7.9e-33 112.6 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 CCF39779.1 - 8.9e-06 25.8 0.0 1.8e-05 24.9 0.0 1.5 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CCF39779.1 - 0.00037 20.5 0.0 0.00083 19.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 CCF39779.1 - 0.064 13.6 0.5 0.89 9.9 0.1 2.5 2 1 0 2 2 2 0 Glutathione S-transferase, N-terminal domain Pkinase PF00069.25 CCF39782.1 - 4.5e-21 75.4 0.0 8e-21 74.6 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Response_reg PF00072.24 CCF39782.1 - 8.2e-16 58.2 0.0 1.4e-15 57.4 0.0 1.4 1 0 0 1 1 1 1 Response regulator receiver domain Pkinase_Tyr PF07714.17 CCF39782.1 - 8.4e-06 25.3 0.0 1.4e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Fungal_trans PF04082.18 CCF39783.1 - 3.8e-15 55.6 0.0 5.4e-15 55.1 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF39783.1 - 1.1e-07 31.8 9.8 2.1e-07 30.9 9.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Hydrolase PF00702.26 CCF39784.1 - 0.0047 17.2 0.0 0.006 16.9 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Tachystatin_B PF11478.8 CCF39784.1 - 0.02 14.8 1.0 0.033 14.1 0.3 1.7 2 0 0 2 2 2 0 Antimicrobial chitin binding protein tachystatin B HAD_2 PF13419.6 CCF39784.1 - 0.04 14.0 0.0 0.049 13.7 0.0 1.1 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Arf PF00025.21 CCF39785.1 - 1.5e-07 31.1 0.0 1.5e-07 31.0 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 CCF39785.1 - 0.013 15.1 0.0 0.014 15.0 0.0 1.0 1 0 0 1 1 1 0 Ras family MMR_HSR1_Xtn PF16897.5 CCF39785.1 - 0.075 13.0 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain Glyco_transf_17 PF04724.13 CCF39787.1 - 2e-48 165.3 0.0 8.1e-48 163.2 0.0 2.0 1 1 0 1 1 1 1 Glycosyltransferase family 17 ETC_C1_NDUFA4 PF04800.12 CCF39787.1 - 0.095 13.0 0.1 0.18 12.1 0.1 1.4 1 0 0 1 1 1 0 ETC complex I subunit conserved region PRO8NT PF08082.11 CCF39788.1 - 6.2e-80 266.5 3.5 8.1e-80 266.1 3.5 1.1 1 0 0 1 1 1 1 PRO8NT (NUC069), PrP8 N-terminal domain eIF-3c_N PF05470.12 CCF39789.1 - 6e-177 589.6 26.6 6e-177 589.6 26.6 3.1 1 1 1 2 2 2 1 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.27 CCF39789.1 - 2e-14 54.0 0.1 1.2e-13 51.5 0.0 2.5 1 1 0 1 1 1 1 PCI domain Dynactin_p22 PF07426.11 CCF39789.1 - 0.0047 16.8 1.6 0.0047 16.8 1.6 2.8 3 0 0 3 3 3 1 Dynactin subunit p22 DASH_Ask1 PF08655.10 CCF39789.1 - 0.096 12.6 0.2 0.55 10.2 0.1 2.3 2 0 0 2 2 2 0 DASH complex subunit Ask1 DUF2779 PF11074.8 CCF39789.1 - 0.16 12.5 3.9 1.2 9.6 0.1 3.7 3 2 0 3 3 3 0 Domain of unknown function(DUF2779) Aminotran_5 PF00266.19 CCF39790.1 - 1.6e-08 33.9 0.0 5.8e-08 32.1 0.0 1.9 1 1 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 CCF39790.1 - 8.7e-06 24.5 0.0 1.2e-05 24.0 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 CCF39790.1 - 0.0064 15.8 0.1 0.011 15.1 0.1 1.4 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.21 CCF39790.1 - 0.065 12.4 0.0 0.11 11.7 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class I and II PHO4 PF01384.20 CCF39791.1 - 6.3e-116 387.1 17.3 7.3e-116 386.9 17.3 1.0 1 0 0 1 1 1 1 Phosphate transporter family DZR PF12773.7 CCF39792.1 - 0.01 15.9 2.3 0.021 14.8 2.2 1.6 1 1 0 1 1 1 0 Double zinc ribbon DUF2318 PF10080.9 CCF39792.1 - 0.97 9.6 4.3 16 5.7 0.3 2.2 1 1 1 2 2 2 0 Predicted membrane protein (DUF2318) Zn_ribbon_17 PF17120.5 CCF39792.1 - 2.4 7.8 8.6 13 5.5 8.6 2.0 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type ThiF PF00899.21 CCF39793.1 - 1.6e-18 66.9 0.0 3.7e-18 65.8 0.0 1.5 1 1 0 1 1 1 1 ThiF family HTH_Tnp_IS1 PF12759.7 CCF39794.1 - 0.072 12.7 0.2 0.12 12.0 0.2 1.4 1 0 0 1 1 1 0 InsA C-terminal domain DUF4448 PF14610.6 CCF39795.1 - 0.0083 15.9 0.0 0.013 15.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) Asp PF00026.23 CCF39795.1 - 0.03 13.7 0.0 0.088 12.2 0.0 1.7 2 1 0 2 2 2 0 Eukaryotic aspartyl protease SKG6 PF08693.10 CCF39795.1 - 0.058 12.8 4.1 0.14 11.6 4.1 1.7 1 0 0 1 1 1 0 Transmembrane alpha-helix domain LapA_dom PF06305.11 CCF39795.1 - 0.08 12.8 0.1 0.14 12.0 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain ICL PF00463.21 CCF39796.1 - 5.3e-299 992.1 0.4 6e-299 991.9 0.4 1.0 1 0 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.6 CCF39796.1 - 2.4e-11 43.6 0.1 7.7e-11 41.9 0.0 1.8 2 0 0 2 2 2 1 Phosphoenolpyruvate phosphomutase DAO PF01266.24 CCF39797.1 - 6.2e-11 42.5 0.0 6.3e-11 42.5 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CCF39797.1 - 2e-05 24.7 0.2 3.6e-05 23.9 0.2 1.4 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 CCF39797.1 - 0.0011 18.3 0.0 0.0013 18.1 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.12 CCF39797.1 - 0.0021 17.2 0.0 0.0021 17.2 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox PF00070.27 CCF39797.1 - 0.0089 16.6 0.0 0.0099 16.4 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CCF39797.1 - 0.013 15.5 0.1 0.018 15.0 0.1 1.4 1 1 0 1 1 1 0 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 CCF39797.1 - 0.013 14.8 0.0 0.015 14.5 0.0 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 CCF39797.1 - 0.025 14.8 0.0 0.043 14.1 0.0 1.3 1 0 0 1 1 1 0 TrkA-N domain Glu_dehyd_C PF16912.5 CCF39797.1 - 0.03 13.8 0.0 0.03 13.8 0.0 1.1 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus Shikimate_DH PF01488.20 CCF39797.1 - 0.031 14.3 0.0 0.042 13.9 0.0 1.1 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Sacchrp_dh_NADP PF03435.18 CCF39797.1 - 0.034 14.4 0.0 0.037 14.3 0.0 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Thi4 PF01946.17 CCF39797.1 - 0.042 13.1 0.0 0.054 12.7 0.0 1.1 1 0 0 1 1 1 0 Thi4 family FAD_binding_2 PF00890.24 CCF39797.1 - 0.043 12.9 0.0 0.053 12.6 0.0 1.1 1 0 0 1 1 1 0 FAD binding domain ThiF PF00899.21 CCF39797.1 - 0.074 12.4 0.0 0.1 12.0 0.0 1.1 1 0 0 1 1 1 0 ThiF family ApbA PF02558.16 CCF39797.1 - 0.099 12.3 0.1 0.13 11.9 0.1 1.1 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Ldh_1_N PF00056.23 CCF39797.1 - 0.15 12.2 0.0 0.16 12.1 0.0 1.1 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain Pyr_redox_3 PF13738.6 CCF39797.1 - 0.2 10.9 0.0 0.26 10.5 0.0 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NUDIX PF00293.28 CCF39798.1 - 3.6e-18 65.9 1.3 4.5e-18 65.6 1.3 1.1 1 0 0 1 1 1 1 NUDIX domain NUDIX_2 PF13869.6 CCF39798.1 - 0.03 13.9 0.0 0.041 13.5 0.0 1.2 1 0 0 1 1 1 0 Nucleotide hydrolase LSM PF01423.22 CCF39799.1 - 1.2e-14 53.8 0.0 1.8e-14 53.2 0.0 1.3 1 0 0 1 1 1 1 LSM domain Mob1_phocein PF03637.17 CCF39800.1 - 7.9e-71 237.5 0.0 9.7e-71 237.2 0.0 1.1 1 0 0 1 1 1 1 Mob1/phocein family OSCP PF00213.18 CCF39801.1 - 6.7e-49 166.3 1.5 6.7e-49 166.3 1.5 1.4 2 0 0 2 2 2 1 ATP synthase delta (OSCP) subunit KfrA_N PF11740.8 CCF39801.1 - 0.037 14.7 1.1 0.037 14.7 1.1 2.0 2 0 0 2 2 2 0 Plasmid replication region DNA-binding N-term FMO-like PF00743.19 CCF39802.1 - 3.4e-28 98.4 0.0 4.2e-19 68.4 0.0 2.4 2 1 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 CCF39802.1 - 2.4e-14 53.3 0.0 9.8e-12 44.7 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CCF39802.1 - 3.9e-11 42.7 0.0 1.8e-09 37.2 0.0 2.4 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 CCF39802.1 - 2.7e-10 40.0 0.0 6.4e-10 38.7 0.0 1.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CCF39802.1 - 7.7e-07 29.2 0.1 9e-05 22.5 0.1 2.5 1 1 0 1 1 1 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 CCF39802.1 - 2.4e-06 27.7 0.0 1.7e-05 25.0 0.0 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CCF39802.1 - 9.7e-06 25.4 0.9 0.024 14.3 0.0 3.0 3 0 0 3 3 3 2 FAD dependent oxidoreductase Amino_oxidase PF01593.24 CCF39802.1 - 0.00052 19.4 0.0 0.73 9.0 0.0 2.3 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase FAD_binding_3 PF01494.19 CCF39802.1 - 0.21 10.8 0.3 1.1 8.5 0.0 2.0 2 0 0 2 2 2 0 FAD binding domain Cellulase PF00150.18 CCF39803.1 - 1.7e-48 165.5 4.2 2.1e-48 165.2 4.2 1.0 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Pho88 PF10032.9 CCF39804.1 - 1.2e-80 269.0 0.0 1.4e-80 268.8 0.0 1.0 1 0 0 1 1 1 1 Phosphate transport (Pho88) AnkUBD PF18418.1 CCF39804.1 - 0.1 12.8 0.0 0.32 11.2 0.0 1.8 2 0 0 2 2 2 0 Ankyrin ubiquitin-binding domain DUF423 PF04241.15 CCF39807.1 - 0.67 10.2 4.2 0.44 10.8 1.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF423) Sec16_C PF12931.7 CCF39808.1 - 4.9e-115 384.3 0.3 6.9e-115 383.8 0.3 1.2 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 Sec16 PF12932.7 CCF39808.1 - 1.2e-34 119.4 0.3 3.2e-34 118.0 0.0 1.9 2 0 0 2 2 2 1 Vesicle coat trafficking protein Sec16 mid-region Nup96 PF12110.8 CCF39808.1 - 0.0024 17.1 0.1 0.0054 15.9 0.1 1.6 2 0 0 2 2 2 1 Nuclear protein 96 Git3 PF11710.8 CCF39812.1 - 5.5e-21 75.3 4.2 1.2e-20 74.1 4.2 1.6 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 7tm_1 PF00001.21 CCF39812.1 - 0.00037 19.9 5.2 0.00054 19.4 5.2 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) GPR_Gpa2_C PF11970.8 CCF39812.1 - 0.00096 19.2 0.1 0.0028 17.7 0.1 1.8 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 C-term Dicty_CAR PF05462.11 CCF39812.1 - 0.0018 17.5 5.3 0.0028 16.9 5.3 1.2 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor LCE6A PF15858.5 CCF39812.1 - 1.3 9.8 6.6 4.1 8.2 6.6 1.8 1 0 0 1 1 1 0 Late cornified envelope protein 6A family Sugar_tr PF00083.24 CCF39813.1 - 0.00021 20.3 2.8 0.00024 20.1 2.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter GET2 PF08690.10 CCF39813.1 - 0.22 11.2 0.1 0.23 11.1 0.1 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 SUR7 PF06687.12 CCF39814.1 - 0.016 14.9 0.1 0.016 14.9 0.1 1.1 1 0 0 1 1 1 0 SUR7/PalI family MFS_1 PF07690.16 CCF39818.1 - 1.9e-34 119.2 58.2 8.4e-28 97.3 35.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF39818.1 - 0.0059 15.5 7.3 0.0059 15.5 7.3 3.2 1 1 1 3 3 3 2 Sugar (and other) transporter DUF2461 PF09365.10 CCF39820.1 - 5.4e-83 278.1 0.5 8.5e-83 277.4 0.5 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein (DUF2461) Pox_Ag35 PF03286.14 CCF39820.1 - 0.0025 17.6 5.4 0.0025 17.6 5.4 3.2 2 1 1 3 3 3 1 Pox virus Ag35 surface protein SDA1 PF05285.12 CCF39820.1 - 4.2 6.7 34.6 1.9 7.9 8.6 2.5 2 0 0 2 2 2 0 SDA1 Pkinase PF00069.25 CCF39822.1 - 7.1e-17 61.6 0.0 1.6e-07 30.9 0.0 2.5 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCF39822.1 - 1.6e-05 24.3 0.3 0.16 11.2 0.0 3.4 4 0 0 4 4 4 2 Protein tyrosine kinase APH PF01636.23 CCF39822.1 - 0.011 15.7 1.7 0.035 14.0 0.0 2.1 2 0 0 2 2 2 0 Phosphotransferase enzyme family Kinase-like PF14531.6 CCF39822.1 - 0.05 12.9 0.1 27 3.9 0.0 3.0 3 0 0 3 3 3 0 Kinase-like Kdo PF06293.14 CCF39822.1 - 0.1 11.9 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RGP PF03214.13 CCF39823.1 - 0.068 12.3 0.0 0.079 12.1 0.0 1.1 1 0 0 1 1 1 0 Reversibly glycosylated polypeptide OTT_1508_deam PF14441.6 CCF39824.1 - 2.7e-18 65.7 0.0 5e-18 64.9 0.0 1.5 1 0 0 1 1 1 1 OTT_1508-like deaminase DUF3734 PF12536.8 CCF39825.1 - 0.012 15.9 3.1 0.012 15.9 3.1 2.4 2 1 0 2 2 2 0 Patatin phospholipase DUF2271 PF10029.9 CCF39825.1 - 0.027 14.1 0.9 0.054 13.1 0.9 1.5 1 0 0 1 1 1 0 Predicted periplasmic protein (DUF2271) F-box PF00646.33 CCF39827.1 - 6.8e-09 35.4 0.5 6.8e-09 35.4 0.5 2.6 3 0 0 3 3 3 1 F-box domain F-box-like PF12937.7 CCF39827.1 - 1.8e-07 30.9 2.4 3.3e-07 30.1 0.3 2.3 2 0 0 2 2 2 1 F-box-like RPEL PF02755.15 CCF39827.1 - 1e-05 25.1 0.1 0.00019 21.0 0.1 2.6 2 0 0 2 2 2 1 RPEL repeat F-box_4 PF15966.5 CCF39827.1 - 0.0021 18.0 2.4 0.0034 17.3 0.0 2.2 2 0 0 2 2 2 1 F-box zf-RING_UBOX PF13445.6 CCF39828.1 - 2.5e-05 24.2 8.0 2.5e-05 24.2 8.0 1.8 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 CCF39828.1 - 0.00038 20.3 12.4 0.0009 19.1 9.9 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CCF39828.1 - 0.0028 17.6 10.8 0.02 14.8 11.0 2.2 1 1 1 2 2 2 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 CCF39828.1 - 0.02 15.1 10.8 0.037 14.2 10.8 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 CCF39828.1 - 0.025 14.9 11.3 0.025 14.9 11.3 1.8 2 0 0 2 2 2 0 Ring finger domain zf-C3HC4_2 PF13923.6 CCF39828.1 - 0.031 14.1 10.9 0.031 14.1 10.9 1.9 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CCF39828.1 - 0.11 12.3 11.2 0.69 9.8 11.1 2.1 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 CEBP_ZZ PF16366.5 CCF39828.1 - 1.2 9.5 9.9 0.21 11.9 5.5 1.9 1 1 1 2 2 2 0 Cytoplasmic polyadenylation element-binding protein ZZ domain zf-CRD PF17979.1 CCF39828.1 - 2.4 8.2 11.0 1.4 9.1 8.7 1.7 1 1 1 2 2 2 0 Cysteine rich domain with multizinc binding regions FYVE PF01363.21 CCF39828.1 - 5.7 7.2 12.7 2.8e+02 1.7 12.7 2.6 1 1 0 1 1 1 0 FYVE zinc finger Peptidase_M14 PF00246.24 CCF39829.1 - 5.4e-38 131.4 0.1 7.9e-38 130.9 0.1 1.2 1 0 0 1 1 1 1 Zinc carboxypeptidase Zn_clus PF00172.18 CCF39831.1 - 8.6e-10 38.6 11.2 1.3e-09 38.0 11.2 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF695 PF05117.12 CCF39831.1 - 0.04 14.1 0.0 0.11 12.7 0.0 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF695) DUF2312 PF10073.9 CCF39831.1 - 0.051 13.2 0.4 0.12 12.0 0.4 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2312) Trimer_CC PF08954.11 CCF39831.1 - 0.33 10.6 3.7 0.84 9.2 3.7 1.7 1 0 0 1 1 1 0 Trimerisation motif Sld5 PF05916.11 CCF39833.1 - 1.6e-31 109.0 0.0 2.5e-31 108.4 0.0 1.3 1 0 0 1 1 1 1 GINS complex protein Pkinase PF00069.25 CCF39834.1 - 1.9e-10 40.5 0.0 1.2e-06 28.1 0.0 2.5 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCF39834.1 - 7.8e-07 28.6 0.0 2.5e-06 27.0 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF39834.1 - 0.17 11.2 0.0 0.3 10.3 0.0 1.3 1 0 0 1 1 1 0 Kinase-like CDC48_2 PF02933.17 CCF39834.1 - 0.18 11.6 0.1 0.43 10.4 0.1 1.6 1 0 0 1 1 1 0 Cell division protein 48 (CDC48), domain 2 Glyco_hydro_72 PF03198.14 CCF39835.1 - 1.3e-88 297.3 0.9 1.9e-87 293.5 0.9 2.0 1 1 0 1 1 1 1 Glucanosyltransferase Cellulase PF00150.18 CCF39835.1 - 0.00034 20.1 0.8 0.0014 18.1 0.8 1.9 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_2_C PF02836.17 CCF39835.1 - 0.0011 18.2 0.1 0.0033 16.6 0.1 1.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Herpes_capsid PF06112.11 CCF39835.1 - 1.7 8.7 6.1 2.8 8.0 6.1 1.2 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein Malate_synthase PF01274.22 CCF39838.1 - 1.6e-131 439.2 0.0 1.8e-131 439.0 0.0 1.0 1 0 0 1 1 1 1 Malate synthase IlvC PF01450.19 CCF39839.1 - 6e-33 114.1 0.0 6.7e-33 114.0 0.0 1.0 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain FPP PF05911.11 CCF39840.1 - 0.00024 19.5 4.8 0.00024 19.5 4.8 1.8 2 0 0 2 2 2 1 Filament-like plant protein, long coiled-coil DUF745 PF05335.13 CCF39840.1 - 0.086 12.6 7.9 0.18 11.5 7.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF745) Golgin_A5 PF09787.9 CCF39840.1 - 0.19 11.1 10.5 0.39 10.1 10.5 1.4 1 0 0 1 1 1 0 Golgin subfamily A member 5 GAS PF13851.6 CCF39840.1 - 0.23 10.8 14.4 0.89 8.9 12.5 2.2 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding DUF5082 PF16888.5 CCF39840.1 - 0.53 10.6 6.6 2.4 8.5 6.6 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF5082) DUF4407 PF14362.6 CCF39840.1 - 0.76 9.1 7.4 1.3 8.3 7.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Filament PF00038.21 CCF39840.1 - 0.88 9.1 14.4 2.6 7.6 14.4 1.6 1 1 0 1 1 1 0 Intermediate filament protein Atg14 PF10186.9 CCF39840.1 - 0.94 8.5 9.1 1.7 7.7 9.1 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Spc7 PF08317.11 CCF39840.1 - 1 8.2 15.1 0.23 10.3 11.3 1.8 2 0 0 2 2 2 0 Spc7 kinetochore protein DUF3450 PF11932.8 CCF39840.1 - 2.3 7.4 8.9 3.9 6.7 8.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DUF1664 PF07889.12 CCF39840.1 - 2.5 8.1 5.2 4.5 7.3 4.6 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) 5_nucleotid PF05761.14 CCF39840.1 - 3.3 6.5 4.7 15 4.3 0.0 2.1 2 0 0 2 2 2 0 5' nucleotidase family Tropomyosin_1 PF12718.7 CCF39840.1 - 5.3 7.2 21.5 1.7 8.8 18.3 1.7 2 0 0 2 2 2 0 Tropomyosin like DUF1308 PF07000.11 CCF39841.1 - 0.00035 20.5 0.0 0.015 15.3 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF1308) DUF3391 PF11871.8 CCF39841.1 - 0.052 14.1 0.0 0.15 12.6 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3391) SnoaL_2 PF12680.7 CCF39842.1 - 0.00028 21.5 0.1 0.00053 20.6 0.1 1.5 1 1 1 2 2 2 1 SnoaL-like domain SnoaL_4 PF13577.6 CCF39842.1 - 0.048 13.8 0.0 0.063 13.4 0.0 1.4 1 1 0 1 1 1 0 SnoaL-like domain SnoaL PF07366.12 CCF39842.1 - 0.063 13.1 0.0 0.089 12.6 0.0 1.2 1 0 0 1 1 1 0 SnoaL-like polyketide cyclase WD40 PF00400.32 CCF39844.1 - 2.5e-08 34.4 4.1 0.87 10.6 0.0 6.6 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF39844.1 - 1.7e-07 31.4 0.0 4.3 7.7 0.0 5.2 1 1 5 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain HEAT PF02985.22 CCF39844.1 - 7.9e-06 25.7 0.7 1.1 9.8 0.1 4.5 5 0 0 5 5 5 2 HEAT repeat BBS2_Mid PF14783.6 CCF39844.1 - 0.0011 19.0 0.1 0.89 9.6 0.0 2.7 1 1 1 2 2 2 2 Ciliary BBSome complex subunit 2, middle region HEAT_2 PF13646.6 CCF39844.1 - 0.0033 17.8 0.0 0.15 12.5 0.0 2.8 2 1 1 3 3 3 2 HEAT repeats Atx10homo_assoc PF09759.9 CCF39844.1 - 0.0072 16.3 0.3 0.013 15.5 0.3 1.4 1 0 0 1 1 1 1 Spinocerebellar ataxia type 10 protein domain HPS3_N PF14761.6 CCF39844.1 - 0.014 14.9 0.0 0.035 13.6 0.0 1.6 1 0 0 1 1 1 0 Hermansky-Pudlak syndrome 3 Cnd1 PF12717.7 CCF39844.1 - 0.021 14.9 0.1 0.48 10.4 0.0 3.0 2 1 1 3 3 3 0 non-SMC mitotic condensation complex subunit 1 Sugar_tr PF00083.24 CCF39845.1 - 5.1e-54 183.8 5.3 6.5e-54 183.5 5.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF39845.1 - 9.6e-11 41.2 14.0 1.2e-10 40.8 14.0 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Zn_clus PF00172.18 CCF39847.1 - 9.4e-07 28.9 15.5 1.6e-06 28.1 15.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain HalX PF08663.10 CCF39847.1 - 0.0051 17.1 0.1 0.01 16.1 0.1 1.5 1 0 0 1 1 1 1 HalX domain DUF3138 PF11336.8 CCF39847.1 - 0.081 11.5 0.0 0.11 11.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) EMP24_GP25L PF01105.24 CCF39847.1 - 0.12 12.3 0.4 0.18 11.8 0.0 1.5 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD AATF-Che1 PF13339.6 CCF39848.1 - 4.5e-28 98.7 1.4 4.5e-28 98.7 1.4 3.4 3 1 0 3 3 3 1 Apoptosis antagonizing transcription factor TRAUB PF08164.12 CCF39848.1 - 1.1e-15 57.9 0.2 1.1e-15 57.9 0.2 3.2 3 0 0 3 3 3 1 Apoptosis-antagonizing transcription factor, C-terminal Peptidase_S64 PF08192.11 CCF39848.1 - 1.5 7.2 10.9 2.7 6.3 10.9 1.4 1 0 0 1 1 1 0 Peptidase family S64 SEN1_N PF12726.7 CCF39851.1 - 3e-176 587.9 11.6 3.9e-176 587.5 11.6 1.1 1 0 0 1 1 1 1 SEN1 N terminal AAA_11 PF13086.6 CCF39851.1 - 9.4e-32 110.8 0.1 9.4e-32 110.8 0.1 3.2 3 0 0 3 3 3 1 AAA domain AAA_30 PF13604.6 CCF39851.1 - 6.2e-06 26.1 0.1 1.8e-05 24.5 0.1 1.9 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CCF39851.1 - 7.3e-06 26.4 0.2 2.4e-05 24.7 0.2 1.9 1 0 0 1 1 1 1 AAA domain UvrD-helicase PF00580.21 CCF39851.1 - 0.0007 19.2 1.2 0.01 15.4 0.0 2.9 1 1 2 3 3 3 1 UvrD/REP helicase N-terminal domain AAA_22 PF13401.6 CCF39851.1 - 0.037 14.3 0.0 0.17 12.2 0.0 2.2 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 CCF39851.1 - 0.088 13.2 0.4 0.26 11.7 0.4 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PARP PF00644.20 CCF39852.1 - 1.3e-58 197.8 0.7 2.7e-58 196.8 0.0 1.9 2 0 0 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.14 CCF39852.1 - 2.7e-44 150.6 0.1 5.2e-44 149.7 0.1 1.5 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain WGR PF05406.15 CCF39852.1 - 3.6e-22 78.2 0.8 1e-21 76.8 0.8 1.8 1 0 0 1 1 1 1 WGR domain BRCT PF00533.26 CCF39852.1 - 3.2e-10 40.2 0.0 6.8e-10 39.2 0.0 1.6 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 CCF39852.1 - 2.8e-08 33.6 0.2 6.8e-08 32.3 0.2 1.7 1 0 0 1 1 1 1 twin BRCT domain BRCT_2 PF16589.5 CCF39852.1 - 2.5e-05 24.6 0.0 5.5e-05 23.5 0.0 1.6 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain CENP-U PF13097.6 CCF39852.1 - 0.38 10.7 6.3 0.73 9.8 6.3 1.4 1 0 0 1 1 1 0 CENP-A nucleosome associated complex (NAC) subunit MCM_bind PF09739.9 CCF39852.1 - 0.69 8.3 2.4 1 7.7 2.4 1.2 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor F-box PF00646.33 CCF39853.1 - 0.00037 20.3 1.3 0.00095 19.0 1.3 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 CCF39853.1 - 0.0004 20.2 0.1 0.00076 19.3 0.1 1.4 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.7 CCF39853.1 - 0.038 14.4 0.7 61 4.2 0.1 3.7 3 0 0 3 3 3 0 Leucine Rich repeats (2 copies) F-box_4 PF15966.5 CCF39853.1 - 0.098 12.6 0.4 0.36 10.7 0.1 2.2 2 0 0 2 2 2 0 F-box Glyco_hydro_88 PF07470.13 CCF39854.1 - 2.3e-66 224.2 5.7 2.9e-66 223.9 5.7 1.0 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 Aminotran_1_2 PF00155.21 CCF39855.1 - 6.6e-30 104.5 0.0 7.3e-30 104.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II PHD PF00628.29 CCF39856.1 - 2.9e-13 49.5 16.9 5.4e-08 32.6 8.2 2.5 2 0 0 2 2 2 2 PHD-finger zf-HC5HC2H PF13771.6 CCF39856.1 - 0.015 15.5 5.0 0.23 11.8 1.6 2.5 2 0 0 2 2 2 0 PHD-like zinc-binding domain C1_1 PF00130.22 CCF39856.1 - 0.15 12.0 14.0 0.52 10.2 0.5 2.9 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) AdoMet_Synthase PF01941.19 CCF39856.1 - 0.17 10.6 0.0 0.26 10.0 0.0 1.1 1 0 0 1 1 1 0 S-adenosylmethionine synthetase (AdoMet synthetase) PHD_2 PF13831.6 CCF39856.1 - 0.2 11.3 13.9 0.36 10.4 4.1 3.2 3 0 0 3 3 3 0 PHD-finger zf-PHD-like PF15446.6 CCF39856.1 - 1.3 8.6 10.0 8.4 6.0 3.8 2.7 2 0 0 2 2 2 0 PHD/FYVE-zinc-finger like domain Prok-RING_1 PF14446.6 CCF39856.1 - 6.1 6.8 14.3 13 5.8 1.2 2.7 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 Zf_RING PF16744.5 CCF39856.1 - 8.6 6.6 13.9 3.8 7.7 0.3 2.9 2 1 1 3 3 3 0 KIAA1045 RING finger Sugar_tr PF00083.24 CCF39857.1 - 3e-84 283.5 18.5 3.4e-84 283.3 18.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF39857.1 - 9.6e-18 64.2 26.2 1.4e-16 60.4 20.6 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 CCF39857.1 - 7.7e-05 21.4 21.6 0.0032 16.1 7.2 2.9 2 1 1 3 3 3 2 MFS/sugar transport protein Pro_isomerase PF00160.21 CCF39859.1 - 1.2e-40 139.4 0.2 1.4e-40 139.1 0.2 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Fungal_trans PF04082.18 CCF39860.1 - 0.0036 16.4 0.0 0.0063 15.6 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF2897 PF11446.8 CCF39861.1 - 0.11 12.4 0.5 0.16 11.8 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2897) FMN_dh PF01070.18 CCF39862.1 - 6.1e-99 331.3 0.8 2e-98 329.6 0.8 1.7 1 1 0 1 1 1 1 FMN-dependent dehydrogenase Glu_synthase PF01645.17 CCF39862.1 - 6.3e-07 28.9 0.2 9.9e-07 28.2 0.2 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 CCF39862.1 - 2.3e-05 23.6 0.3 0.00032 19.8 0.1 2.1 2 0 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain ThiG PF05690.14 CCF39862.1 - 0.002 17.5 0.5 0.69 9.2 0.2 2.6 2 1 0 3 3 3 2 Thiazole biosynthesis protein ThiG NMO PF03060.15 CCF39862.1 - 0.0062 16.0 0.3 0.01 15.2 0.3 1.4 1 0 0 1 1 1 1 Nitronate monooxygenase His_biosynth PF00977.21 CCF39862.1 - 0.037 13.5 0.1 0.08 12.4 0.1 1.6 2 0 0 2 2 2 0 Histidine biosynthesis protein Lipase_3 PF01764.25 CCF39863.1 - 1.6e-13 50.7 0.0 3.5e-12 46.4 0.0 2.4 1 1 0 1 1 1 1 Lipase (class 3) Amino_oxidase PF01593.24 CCF39864.1 - 2.1e-08 33.9 0.0 3.7e-08 33.1 0.0 1.4 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CCF39864.1 - 1.2e-07 31.8 0.1 2.9e-07 30.6 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CCF39864.1 - 0.00086 18.6 0.1 0.011 15.0 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 CCF39864.1 - 0.0098 15.2 0.1 0.015 14.6 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.12 CCF39864.1 - 0.044 12.8 1.3 0.093 11.8 0.2 1.9 2 0 0 2 2 2 0 Lycopene cyclase protein Pyr_redox_3 PF13738.6 CCF39864.1 - 0.045 13.0 0.1 0.081 12.2 0.1 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CCF39864.1 - 0.047 12.4 0.1 0.07 11.8 0.1 1.2 1 0 0 1 1 1 0 HI0933-like protein Thi4 PF01946.17 CCF39864.1 - 0.048 12.9 0.1 0.089 12.0 0.1 1.4 1 0 0 1 1 1 0 Thi4 family FAD_binding_2 PF00890.24 CCF39864.1 - 0.096 11.7 0.2 0.15 11.1 0.2 1.2 1 0 0 1 1 1 0 FAD binding domain DAO PF01266.24 CCF39864.1 - 0.11 12.0 0.1 0.18 11.3 0.1 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase DUF1344 PF07076.11 CCF39864.1 - 0.12 12.3 0.1 0.25 11.3 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1344) FAD_oxidored PF12831.7 CCF39864.1 - 0.15 11.4 0.0 0.21 10.9 0.0 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase 6PF2K PF01591.18 CCF39865.1 - 4.7e-64 215.7 0.0 3.7e-46 157.2 0.0 2.2 2 0 0 2 2 2 2 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 CCF39865.1 - 1.5e-29 103.1 0.0 3.1e-23 82.5 0.0 2.5 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 CCF39865.1 - 0.0023 18.1 0.0 0.018 15.2 0.0 2.2 1 1 0 1 1 1 1 AAA domain CARD PF00619.21 CCF39865.1 - 0.02 14.9 0.5 0.093 12.8 0.5 2.0 1 1 0 1 1 1 0 Caspase recruitment domain KTI12 PF08433.10 CCF39865.1 - 0.061 12.8 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 RuBisCO_small PF00101.20 CCF39865.1 - 0.069 13.1 0.0 43 4.2 0.1 3.2 3 0 0 3 3 3 0 Ribulose bisphosphate carboxylase, small chain Gaa1 PF04114.14 CCF39866.1 - 1.4e-139 466.4 11.2 5.8e-93 312.6 0.0 2.0 1 1 1 2 2 2 2 Gaa1-like, GPI transamidase component Rhomboid PF01694.22 CCF39867.1 - 7.2e-15 55.3 9.9 8.8e-15 55.0 9.9 1.1 1 0 0 1 1 1 1 Rhomboid family Glyco_hydro_10 PF00331.20 CCF39869.1 - 7.5e-98 327.6 0.0 8.7e-98 327.3 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 RIG-I_C PF18119.1 CCF39870.1 - 0.023 14.7 0.1 0.029 14.4 0.1 1.2 1 0 0 1 1 1 0 RIG-I receptor C-terminal domain Ribosomal_60s PF00428.19 CCF39871.1 - 4.7e-27 94.4 10.2 5.7e-27 94.1 10.2 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein UBA PF00627.31 CCF39872.1 - 9.6e-07 28.6 0.0 2.2e-06 27.5 0.0 1.7 1 0 0 1 1 1 1 UBA/TS-N domain UBX PF00789.20 CCF39872.1 - 2.3e-05 24.5 0.5 6.7e-05 23.0 0.0 2.0 2 0 0 2 2 2 1 UBX domain THRAP3_BCLAF1 PF15440.6 CCF39872.1 - 0.0055 15.8 16.1 0.0059 15.7 16.1 1.1 1 0 0 1 1 1 1 THRAP3/BCLAF1 family zf-C2H2_6 PF13912.6 CCF39872.1 - 0.027 14.5 0.3 0.057 13.4 0.3 1.5 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2_2 PF12756.7 CCF39872.1 - 0.063 13.6 1.0 0.1 12.9 0.2 1.8 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.26 CCF39872.1 - 0.068 13.7 0.4 0.14 12.7 0.4 1.6 1 0 0 1 1 1 0 Zinc finger, C2H2 type SOBP PF15279.6 CCF39872.1 - 1.5 9.4 5.0 1.9 9.0 5.0 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein V_ATPase_I PF01496.19 CCF39872.1 - 5.7 4.7 10.0 6.4 4.6 10.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family GAGA_bind PF06217.12 CCF39872.1 - 8.6 6.6 15.4 12 6.1 15.4 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family Motile_Sperm PF00635.26 CCF39873.1 - 1.3e-24 86.1 2.4 1.9e-24 85.6 0.5 2.2 2 1 1 3 3 3 1 MSP (Major sperm protein) domain ASH PF15780.5 CCF39873.1 - 0.0007 19.7 1.6 0.0037 17.5 0.1 2.6 2 1 1 3 3 3 1 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin TRIQK PF15168.6 CCF39873.1 - 0.054 13.4 0.1 0.099 12.5 0.1 1.4 1 0 0 1 1 1 0 Triple QxxK/R motif-containing protein family FA_desaturase PF00487.24 CCF39874.1 - 2.2e-24 86.7 16.1 2.2e-24 86.7 16.1 1.7 1 1 1 2 2 2 2 Fatty acid desaturase Lipid_DES PF08557.10 CCF39874.1 - 1.4e-18 66.0 0.1 2.6e-18 65.2 0.1 1.5 1 0 0 1 1 1 1 Sphingolipid Delta4-desaturase (DES) ICE2 PF08426.10 CCF39875.1 - 1.2e-35 123.5 0.8 1.3e-35 123.3 0.8 1.0 1 0 0 1 1 1 1 ICE2 SMC_N PF02463.19 CCF39878.1 - 6.1e-06 25.8 10.8 1.3e-05 24.8 10.8 1.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain NPV_P10 PF05531.12 CCF39878.1 - 0.058 13.9 8.3 0.23 11.9 0.1 4.0 3 2 1 4 4 4 0 Nucleopolyhedrovirus P10 protein BLOC1_2 PF10046.9 CCF39878.1 - 0.18 12.1 0.2 0.18 12.1 0.2 4.1 2 2 2 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TPR_MLP1_2 PF07926.12 CCF39878.1 - 0.42 10.7 35.6 0.55 10.3 0.1 4.3 2 1 2 4 4 4 0 TPR/MLP1/MLP2-like protein Occludin_ELL PF07303.13 CCF39878.1 - 1.3 9.8 16.6 4.2 8.1 3.9 3.7 2 1 2 4 4 4 0 Occludin homology domain Fez1 PF06818.15 CCF39878.1 - 2.8 8.3 36.4 1.3 9.4 2.7 2.8 1 1 2 3 3 3 0 Fez1 MCC-bdg_PDZ PF10506.9 CCF39878.1 - 7.4 6.7 11.0 5.4 7.1 0.6 4.2 4 0 0 4 4 4 0 PDZ domain of MCC-2 bdg protein for Usher syndrome DUF5082 PF16888.5 CCF39878.1 - 9.9 6.5 20.4 0.91 9.8 0.4 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF5082) Na_Ca_ex PF01699.24 CCF39879.1 - 2e-44 151.2 35.7 4.1e-24 85.3 14.4 2.2 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Swi5 PF07061.11 CCF39882.1 - 1.9e-19 69.5 0.0 1.9e-19 69.5 0.0 1.0 1 0 0 1 1 1 1 Swi5 AdoMet_Synthase PF01941.19 CCF39882.1 - 0.12 11.1 0.1 0.13 11.0 0.1 1.0 1 0 0 1 1 1 0 S-adenosylmethionine synthetase (AdoMet synthetase) Lactamase_B_3 PF13483.6 CCF39883.1 - 7e-06 26.0 0.0 1.1e-05 25.4 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_2 PF12706.7 CCF39883.1 - 4.6e-05 23.0 2.0 0.00072 19.1 0.7 2.9 2 1 0 2 2 2 1 Beta-lactamase superfamily domain UIM PF02809.20 CCF39884.1 - 0.36 10.8 2.9 0.7 9.9 2.9 1.5 1 0 0 1 1 1 0 Ubiquitin interaction motif NAD_binding_6 PF08030.12 CCF39889.1 - 4.7e-32 111.3 0.0 1e-31 110.2 0.0 1.5 2 0 0 2 2 2 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 CCF39889.1 - 8.8e-20 70.8 1.9 1.4e-19 70.2 0.0 2.3 3 0 0 3 3 3 1 FAD-binding domain Ferric_reduct PF01794.19 CCF39889.1 - 4.5e-05 23.6 2.3 9.6e-05 22.5 2.3 1.6 1 0 0 1 1 1 1 Ferric reductase like transmembrane component DUF2017 PF09438.10 CCF39889.1 - 0.24 11.3 0.0 0.37 10.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2017) Fungal_trans_2 PF11951.8 CCF39890.1 - 5.7e-08 32.0 0.3 7.9e-08 31.5 0.3 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain ABC_tran PF00005.27 CCF39891.1 - 9.6e-15 55.3 0.0 1.2e-14 55.0 0.0 1.0 1 0 0 1 1 1 1 ABC transporter AAA_29 PF13555.6 CCF39891.1 - 0.0006 19.5 0.3 0.00087 19.0 0.3 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain PRK PF00485.18 CCF39891.1 - 0.002 17.9 0.4 0.017 14.9 0.4 1.9 1 1 1 2 2 2 1 Phosphoribulokinase / Uridine kinase family AAA_21 PF13304.6 CCF39891.1 - 0.0023 17.8 0.1 0.003 17.4 0.1 1.1 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system CbiA PF01656.23 CCF39891.1 - 0.0054 16.8 0.1 0.0092 16.0 0.1 1.3 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_33 PF13671.6 CCF39891.1 - 0.0093 16.1 0.1 0.011 15.9 0.1 1.3 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CCF39891.1 - 0.01 16.1 0.2 0.01 16.1 0.2 1.4 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 CCF39891.1 - 0.015 15.7 0.2 0.018 15.5 0.2 1.4 1 1 0 1 1 1 0 AAA ATPase domain AAA_18 PF13238.6 CCF39891.1 - 0.018 15.6 0.5 0.018 15.6 0.5 1.3 1 1 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.18 CCF39891.1 - 0.02 14.2 0.3 0.032 13.6 0.3 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family T2SSE PF00437.20 CCF39891.1 - 0.023 13.7 0.4 0.051 12.6 0.1 1.7 1 1 1 2 2 2 0 Type II/IV secretion system protein RsgA_GTPase PF03193.16 CCF39891.1 - 0.041 13.8 0.2 0.041 13.8 0.2 1.4 2 0 0 2 2 1 0 RsgA GTPase AAA_23 PF13476.6 CCF39891.1 - 0.046 14.2 0.2 0.057 13.9 0.1 1.4 2 0 0 2 2 1 0 AAA domain TrwB_AAD_bind PF10412.9 CCF39891.1 - 0.052 12.4 0.1 0.071 12.0 0.1 1.2 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain MMR_HSR1 PF01926.23 CCF39891.1 - 0.078 13.1 0.1 0.13 12.3 0.0 1.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_24 PF13479.6 CCF39891.1 - 0.085 12.6 0.1 0.1 12.3 0.1 1.3 1 1 0 1 1 1 0 AAA domain cobW PF02492.19 CCF39891.1 - 0.09 12.4 1.1 0.17 11.4 0.4 1.7 1 1 1 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 CCF39891.1 - 0.12 11.3 0.3 0.12 11.3 0.3 1.6 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Hpr_kinase_C PF07475.12 CCF39891.1 - 0.13 11.8 0.2 0.17 11.4 0.2 1.2 1 0 0 1 1 1 0 HPr Serine kinase C-terminal domain AAA_15 PF13175.6 CCF39891.1 - 0.14 11.8 0.0 0.14 11.8 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain APS_kinase PF01583.20 CCF39891.1 - 0.16 11.9 0.4 0.27 11.1 0.2 1.5 1 1 0 1 1 1 0 Adenylylsulphate kinase Dynamin_N PF00350.23 CCF39891.1 - 0.16 12.0 0.9 0.17 12.0 0.9 1.4 1 1 0 1 1 1 0 Dynamin family NAD_binding_4 PF07993.12 CCF39892.1 - 3.7e-32 111.5 0.0 5.5e-32 111.0 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.21 CCF39892.1 - 5.2e-12 45.7 0.0 7.3e-12 45.3 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CCF39892.1 - 0.002 17.6 0.0 0.0068 15.8 0.0 1.7 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase PRAI PF00697.22 CCF39892.1 - 0.016 15.0 0.0 0.03 14.1 0.0 1.4 1 0 0 1 1 1 0 N-(5'phosphoribosyl)anthranilate (PRA) isomerase RmlD_sub_bind PF04321.17 CCF39892.1 - 0.017 14.2 0.0 2.1 7.4 0.0 2.9 2 1 0 2 2 2 0 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 CCF39892.1 - 0.045 12.9 0.0 0.23 10.6 0.0 1.9 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein KR PF08659.10 CCF39892.1 - 0.18 11.7 0.0 0.4 10.6 0.0 1.5 1 0 0 1 1 1 0 KR domain tRNA-synt_2b PF00587.25 CCF39893.1 - 1.5e-30 106.5 0.0 1.1e-28 100.4 0.0 2.3 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 CCF39893.1 - 2.6e-20 72.4 0.2 5.2e-20 71.4 0.2 1.5 1 0 0 1 1 1 1 Anticodon binding domain tRNA_SAD PF07973.14 CCF39893.1 - 4.8e-11 42.6 0.0 1.2e-10 41.4 0.0 1.7 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain TGS PF02824.21 CCF39893.1 - 9.9e-11 41.5 0.0 2e-10 40.6 0.0 1.5 1 0 0 1 1 1 1 TGS domain PepSY_like PF11396.8 CCF39893.1 - 0.032 14.8 0.5 0.42 11.2 0.1 2.8 3 0 0 3 3 3 0 Putative beta-lactamase-inhibitor-like, PepSY-like CDP-OH_P_transf PF01066.21 CCF39894.1 - 6.6e-11 42.8 0.1 2e-10 41.3 0.1 1.8 1 0 0 1 1 1 1 CDP-alcohol phosphatidyltransferase FAD_binding_3 PF01494.19 CCF39896.1 - 9.6e-26 90.8 0.2 6e-15 55.3 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 CCF39896.1 - 0.00047 19.5 2.1 0.083 12.1 0.1 2.6 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 CCF39896.1 - 0.0028 16.6 0.6 0.082 11.7 0.0 2.3 2 0 0 2 2 2 1 Tryptophan halogenase Pyr_redox_3 PF13738.6 CCF39896.1 - 0.011 15.0 1.3 0.19 11.0 0.7 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCF39896.1 - 0.028 14.0 0.7 0.071 12.7 0.3 1.7 2 0 0 2 2 2 0 FAD dependent oxidoreductase Amino_oxidase PF01593.24 CCF39896.1 - 0.031 13.6 0.3 0.66 9.2 0.0 2.2 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CCF39896.1 - 0.13 12.5 0.3 0.28 11.4 0.3 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 CCF39896.1 - 0.22 12.1 5.8 0.23 12.0 0.4 3.0 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase MT0933_antitox PF14013.6 CCF39897.1 - 0.034 14.4 5.4 0.034 14.4 5.4 1.7 2 0 0 2 2 2 0 MT0933-like antitoxin protein Cpn60_TCP1 PF00118.24 CCF39898.1 - 2.2e-153 511.4 13.1 2.5e-153 511.2 13.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family CRT10 PF08728.10 CCF39901.1 - 0.22 9.6 0.0 0.52 8.4 0.0 1.5 2 0 0 2 2 2 0 CRT10 YCII PF03795.14 CCF39902.1 - 1.2e-08 35.2 0.0 1.6e-08 34.8 0.0 1.1 1 0 0 1 1 1 1 YCII-related domain DUF2408 PF10303.9 CCF39903.1 - 1.4e-40 139.0 3.6 3.9e-27 95.5 0.1 3.9 3 1 1 4 4 4 3 Protein of unknown function (DUF2408) Csm1_N PF18504.1 CCF39903.1 - 0.035 14.4 5.0 2.6 8.4 0.1 3.8 4 0 0 4 4 4 0 Csm1 N-terminal domain Spc7 PF08317.11 CCF39903.1 - 0.052 12.4 3.7 0.15 10.9 3.7 1.7 1 1 0 1 1 1 0 Spc7 kinetochore protein Blo-t-5 PF11642.8 CCF39903.1 - 0.089 12.8 1.2 0.79 9.7 0.2 2.8 2 1 1 3 3 3 0 Mite allergen Blo t 5 Laminin_II PF06009.12 CCF39903.1 - 0.21 11.6 2.5 0.47 10.5 1.0 2.2 1 1 1 2 2 2 0 Laminin Domain II Nup54 PF13874.6 CCF39903.1 - 0.42 10.7 2.7 1.1 9.4 2.6 1.8 1 1 0 1 1 1 0 Nucleoporin complex subunit 54 ABC_tran_CTD PF16326.5 CCF39903.1 - 0.46 10.8 4.0 0.76 10.1 1.6 2.6 1 1 2 3 3 3 0 ABC transporter C-terminal domain Prefoldin_2 PF01920.20 CCF39903.1 - 0.47 10.4 3.6 8.9 6.3 0.1 2.9 2 1 0 2 2 2 0 Prefoldin subunit K-box PF01486.17 CCF39903.1 - 1.2 9.3 6.3 0.95 9.7 1.0 2.7 1 1 0 2 2 2 0 K-box region DASH_Dad3 PF08656.10 CCF39903.1 - 2.4 8.3 6.7 2.4e+02 1.9 7.2 3.0 2 1 0 2 2 2 0 DASH complex subunit Dad3 Snapin_Pallidin PF14712.6 CCF39903.1 - 2.6 8.5 8.1 7.9 7.0 0.5 3.9 3 1 1 4 4 4 0 Snapin/Pallidin Spc24 PF08286.11 CCF39903.1 - 5.3 7.3 8.8 2.7 8.3 0.7 3.5 2 1 2 4 4 4 0 Spc24 subunit of Ndc80 zf-Tim10_DDP PF02953.15 CCF39904.1 - 1.9e-22 78.7 1.5 2.4e-22 78.3 1.5 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger CorA PF01544.18 CCF39905.1 - 1e-41 143.2 0.0 1.4e-41 142.7 0.0 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein EMP70 PF02990.16 CCF39905.1 - 0.13 10.9 2.4 0.19 10.4 2.4 1.1 1 0 0 1 1 1 0 Endomembrane protein 70 MFS_1 PF07690.16 CCF39906.1 - 9.3e-30 103.7 37.4 4.4e-29 101.5 30.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF39906.1 - 2.4e-13 49.8 8.9 2.4e-13 49.8 8.9 1.7 1 1 0 2 2 2 1 Sugar (and other) transporter BTB_2 PF02214.22 CCF39907.1 - 0.00035 20.9 0.0 0.00075 19.8 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain Wbp11 PF09429.10 CCF39908.1 - 0.045 14.1 0.5 0.092 13.2 0.5 1.4 1 0 0 1 1 1 0 WW domain binding protein 11 TT1725 PF18324.1 CCF39909.1 - 0.0067 16.5 0.0 0.013 15.5 0.0 1.4 1 0 0 1 1 1 1 Hypothetical protein TT1725 XPG_I PF00867.18 CCF39910.1 - 7.6e-27 93.5 0.0 1.9e-26 92.3 0.0 1.7 1 0 0 1 1 1 1 XPG I-region GEN1_C PF18380.1 CCF39910.1 - 2.3e-12 47.7 0.0 9.9e-12 45.7 0.0 2.1 2 0 0 2 2 2 1 Holliday junction resolvase Gen1 C-terminal domain XPG_N PF00752.17 CCF39910.1 - 4e-05 24.0 0.0 8.9e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I_2 PF12813.7 CCF39910.1 - 0.22 11.0 0.6 0.38 10.2 0.0 1.6 2 0 0 2 2 2 0 XPG domain containing Dicty_REP PF05086.12 CCF39910.1 - 1.5 6.7 5.2 2.1 6.2 5.2 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Peptidase_C48 PF02902.19 CCF39911.1 - 3.5e-17 63.0 0.0 5.9e-17 62.2 0.0 1.3 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain SPATIAL PF15256.6 CCF39911.1 - 0.033 14.5 0.2 0.079 13.3 0.2 1.6 1 0 0 1 1 1 0 SPATIAL Glyco_hydro_61 PF03443.14 CCF39912.1 - 1.9e-11 44.3 0.0 2.2e-11 44.1 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 Melittin PF01372.17 CCF39915.1 - 0.028 14.3 0.3 1.3 9.1 0.1 2.5 2 0 0 2 2 2 0 Melittin tRNA-synt_2b PF00587.25 CCF39916.1 - 2.1e-32 112.6 0.0 3.6e-32 111.8 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 CCF39916.1 - 2.4e-08 34.0 0.0 7e-08 32.5 0.0 1.8 1 0 0 1 1 1 1 Anticodon binding domain Ribosomal_L31e PF01198.19 CCF39916.1 - 0.053 13.8 0.0 1.3 9.3 0.0 2.4 2 0 0 2 2 2 0 Ribosomal protein L31e Prefoldin PF02996.17 CCF39917.1 - 2.3e-25 88.9 0.8 3.1e-25 88.4 0.8 1.2 1 0 0 1 1 1 1 Prefoldin subunit CLZ PF16526.5 CCF39917.1 - 0.0057 17.0 6.6 0.77 10.2 0.7 2.2 2 0 0 2 2 2 2 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Prefoldin_2 PF01920.20 CCF39917.1 - 0.021 14.8 6.8 0.44 10.5 0.3 2.1 2 0 0 2 2 2 0 Prefoldin subunit Med30 PF11315.8 CCF39917.1 - 0.024 14.8 4.1 1 9.5 0.2 2.1 2 0 0 2 2 2 0 Mediator complex subunit 30 DUF1539 PF07560.11 CCF39917.1 - 0.047 13.8 0.6 1.8 8.6 0.6 2.1 1 1 0 1 1 1 0 Domain of Unknown Function (DUF1539) UDPG_MGDP_dh_N PF03721.14 CCF39917.1 - 0.055 13.0 0.5 0.067 12.8 0.1 1.4 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain DUF1805 PF08827.11 CCF39917.1 - 0.14 12.5 0.1 0.37 11.2 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1805) Fib_alpha PF08702.10 CCF39917.1 - 0.76 10.0 6.5 7.3 6.8 1.7 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family GIT_CC PF16559.5 CCF39917.1 - 1.1 9.2 9.0 0.3 11.0 2.6 2.3 2 1 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor Spc24 PF08286.11 CCF39917.1 - 2.9 8.2 6.5 9.3 6.6 0.5 2.2 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 SNF2_N PF00176.23 CCF39919.1 - 5e-06 25.5 0.0 5.5e-06 25.3 0.0 1.1 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CCF39920.1 - 7.2e-13 48.9 0.0 8.2e-13 48.7 0.0 1.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 CCF39920.1 - 0.12 11.6 0.0 0.13 11.4 0.0 1.0 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase AA_permease PF00324.21 CCF39921.1 - 2.2e-65 221.1 11.8 3.1e-65 220.6 11.8 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CCF39921.1 - 3.5e-16 59.0 16.2 4.7e-16 58.6 16.2 1.1 1 0 0 1 1 1 1 Amino acid permease Endonuclease_NS PF01223.23 CCF39923.1 - 6e-67 225.8 0.0 7.4e-67 225.5 0.0 1.1 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease WD40 PF00400.32 CCF39924.1 - 4.3e-08 33.7 6.9 0.00013 22.6 0.5 2.4 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF39924.1 - 0.023 15.0 0.0 0.55 10.6 0.0 2.1 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain bZIP_2 PF07716.15 CCF39925.1 - 0.0015 18.6 12.8 0.0024 17.9 12.8 1.3 1 0 0 1 1 1 1 Basic region leucine zipper EMP24_GP25L PF01105.24 CCF39925.1 - 0.27 11.1 0.9 0.39 10.7 0.9 1.1 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD bZIP_1 PF00170.21 CCF39925.1 - 2.4 8.3 13.3 4.7 7.4 13.3 1.4 1 1 0 1 1 1 0 bZIP transcription factor Cellulase PF00150.18 CCF39926.1 - 1.9e-21 76.7 1.8 2.6e-21 76.3 1.8 1.2 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) CBM_1 PF00734.18 CCF39926.1 - 1.4e-11 44.1 11.1 1.4e-11 44.1 11.1 2.5 2 0 0 2 2 2 1 Fungal cellulose binding domain Glyco_hydro_2_C PF02836.17 CCF39926.1 - 1.7e-05 24.1 0.1 2.7e-05 23.4 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain DUF4038 PF13204.6 CCF39926.1 - 7.4e-05 22.5 0.3 0.00011 21.9 0.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF4038) Glyco_hydro_42 PF02449.15 CCF39926.1 - 0.00051 19.5 0.3 0.0012 18.3 0.2 1.5 2 0 0 2 2 2 1 Beta-galactosidase Toxin_7 PF05980.12 CCF39926.1 - 2.2 8.6 7.4 0.32 11.3 2.6 2.2 2 0 0 2 2 2 0 Toxin 7 LysM PF01476.20 CCF39927.1 - 2.3e-11 43.6 0.0 3.8e-11 42.9 0.0 1.4 1 0 0 1 1 1 1 LysM domain Actino_peptide PF14408.6 CCF39927.1 - 0.053 13.6 0.1 0.091 12.9 0.1 1.5 1 0 0 1 1 1 0 Ribosomally synthesised peptide in actinomycetes DUF903 PF06004.12 CCF39927.1 - 0.066 13.1 1.0 0.17 11.8 1.0 1.6 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF903) IcmF-related PF06761.12 CCF39928.1 - 0.11 12.0 0.0 0.12 11.8 0.0 1.1 1 0 0 1 1 1 0 Intracellular multiplication and human macrophage-killing ExoD PF06055.12 CCF39928.1 - 0.22 10.9 0.6 0.35 10.2 0.5 1.4 1 1 1 2 2 2 0 Exopolysaccharide synthesis, ExoD Utp14 PF04615.13 CCF39929.1 - 2 6.9 13.9 2.4 6.6 13.9 1.1 1 0 0 1 1 1 0 Utp14 protein Macoilin PF09726.9 CCF39929.1 - 2.5 6.6 7.1 2.7 6.4 7.1 1.1 1 0 0 1 1 1 0 Macoilin family Mitofilin PF09731.9 CCF39929.1 - 2.6 6.8 17.7 3.4 6.4 17.7 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein SOBP PF15279.6 CCF39929.1 - 4.6 7.8 23.3 5.8 7.4 23.3 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein FMO-like PF00743.19 CCF39930.1 - 3.2e-14 52.2 0.1 1.2e-10 40.5 0.1 2.8 2 2 0 2 2 2 2 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 CCF39930.1 - 8.4e-11 41.9 0.0 1.7e-10 40.9 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CCF39930.1 - 4.2e-08 32.8 0.0 9.3e-05 21.8 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCF39930.1 - 3.6e-06 26.5 0.0 8.8e-05 21.9 0.0 2.7 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CCF39930.1 - 0.00089 18.5 0.0 0.54 9.3 0.0 2.8 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 CCF39930.1 - 0.0033 17.4 0.0 0.03 14.3 0.0 2.5 3 0 0 3 3 3 1 FAD-NAD(P)-binding DAO PF01266.24 CCF39930.1 - 0.0045 16.6 0.0 2.7 7.5 0.0 3.1 2 1 1 3 3 3 1 FAD dependent oxidoreductase KAAG1 PF15354.6 CCF39931.1 - 0.11 13.1 0.5 0.35 11.4 0.3 1.8 1 1 1 2 2 2 0 Kidney-associated antigen 1 Aldedh PF00171.22 CCF39935.1 - 2.5e-168 560.4 0.5 2.8e-168 560.2 0.5 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family adh_short_C2 PF13561.6 CCF39936.1 - 4.9e-49 167.0 0.0 8.1e-49 166.3 0.0 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF39936.1 - 2.8e-36 124.8 0.0 4.4e-36 124.2 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase Fungal_trans_2 PF11951.8 CCF39936.1 - 2e-19 69.7 0.0 2e-18 66.4 0.0 2.0 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF39936.1 - 7e-08 32.5 13.3 1.3e-07 31.6 11.6 2.1 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain KR PF08659.10 CCF39936.1 - 0.0052 16.7 0.0 0.011 15.7 0.0 1.4 1 0 0 1 1 1 1 KR domain Fungal_trans PF04082.18 CCF39936.1 - 0.0063 15.6 0.2 0.012 14.7 0.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain HTH_psq PF05225.16 CCF39937.1 - 5e-12 45.3 0.1 9.4e-12 44.5 0.1 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.16 CCF39937.1 - 1.4e-11 44.2 0.1 7.6e-11 41.9 0.0 1.9 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_23 PF13384.6 CCF39937.1 - 7.8e-05 22.4 0.1 0.00021 21.0 0.1 1.8 1 1 1 2 2 2 1 Homeodomain-like domain HTH_7 PF02796.15 CCF39937.1 - 0.00044 20.3 0.1 0.00083 19.4 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_30 PF13556.6 CCF39937.1 - 0.001 18.8 0.1 0.0027 17.4 0.1 1.8 2 0 0 2 2 2 1 PucR C-terminal helix-turn-helix domain HTH_28 PF13518.6 CCF39937.1 - 0.0028 17.7 0.7 0.0083 16.2 0.1 2.1 2 1 1 3 3 3 1 Helix-turn-helix domain HTH_Tnp_1 PF01527.20 CCF39937.1 - 0.007 16.7 0.5 0.019 15.2 0.5 1.8 1 1 1 2 2 2 1 Transposase HTH_1 PF00126.27 CCF39937.1 - 0.012 15.5 0.4 0.03 14.3 0.3 1.7 1 1 0 1 1 1 0 Bacterial regulatory helix-turn-helix protein, lysR family CENP-B_N PF04218.13 CCF39937.1 - 0.051 13.2 0.0 0.086 12.5 0.0 1.4 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain SpoIIID PF12116.8 CCF39937.1 - 0.076 13.1 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 Stage III sporulation protein D HTH_8 PF02954.19 CCF39937.1 - 0.13 12.1 0.3 1.5 8.6 0.0 2.4 1 1 1 2 2 2 0 Bacterial regulatory protein, Fis family GSP_synth PF03738.14 CCF39939.1 - 2.4e-108 362.7 0.0 2.9e-108 362.4 0.0 1.0 1 0 0 1 1 1 1 Glutathionylspermidine synthase preATP-grasp CRAL_TRIO PF00650.20 CCF39940.1 - 2e-41 141.4 0.0 3.6e-41 140.6 0.0 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 CCF39940.1 - 8.2e-15 54.7 0.3 2e-14 53.5 0.3 1.7 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 CCF39940.1 - 3.3e-07 30.5 0.0 5.9e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain HIT PF01230.23 CCF39941.1 - 4.2e-13 49.9 0.5 6.6e-13 49.2 0.5 1.3 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 CCF39941.1 - 0.00066 20.1 0.1 0.0012 19.3 0.1 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CN_hydrolase PF00795.22 CCF39943.1 - 4.3e-31 108.2 0.1 5.2e-24 85.0 0.0 2.1 2 0 0 2 2 2 2 Carbon-nitrogen hydrolase OPT PF03169.15 CCF39944.1 - 5.4e-99 332.5 29.8 6.1e-99 332.3 29.8 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein AA_permease PF00324.21 CCF39945.1 - 3.9e-85 286.2 29.3 4.9e-85 285.9 29.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CCF39945.1 - 1.3e-32 113.2 32.0 1.6e-32 112.9 32.0 1.0 1 0 0 1 1 1 1 Amino acid permease ABC2_membrane PF01061.24 CCF39947.1 - 2.5e-38 131.6 27.8 2.5e-38 131.6 27.8 1.5 2 0 0 2 2 2 1 ABC-2 type transporter ABC2_membrane_3 PF12698.7 CCF39947.1 - 1.6e-10 40.6 9.0 1.6e-10 40.6 9.0 1.4 1 1 0 1 1 1 1 ABC-2 family transporter protein PDR_CDR PF06422.12 CCF39947.1 - 0.00049 19.9 0.6 0.00049 19.9 0.6 2.3 3 0 0 3 3 3 1 CDR ABC transporter Aldolase_II PF00596.21 CCF39948.1 - 1.7e-50 171.6 0.2 2.2e-50 171.2 0.2 1.2 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain CTP_transf_1 PF01148.20 CCF39949.1 - 3.3e-30 105.8 0.2 3.6e-30 105.6 0.2 1.1 1 0 0 1 1 1 1 Cytidylyltransferase family HTH_IclR PF09339.10 CCF39950.1 - 0.25 11.2 1.1 0.63 9.9 1.1 1.6 1 0 0 1 1 1 0 IclR helix-turn-helix domain Exo_endo_phos PF03372.23 CCF39953.1 - 1.6e-08 34.4 0.0 2.5e-08 33.7 0.0 1.3 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 CCF39953.1 - 0.056 13.3 0.0 0.4 10.5 0.0 2.3 2 1 0 2 2 2 0 Endonuclease-reverse transcriptase Thioredoxin PF00085.20 CCF39954.1 - 5.2e-26 90.6 0.1 1.1e-25 89.6 0.1 1.5 1 0 0 1 1 1 1 Thioredoxin PITH PF06201.13 CCF39954.1 - 4.1e-14 53.1 0.1 6.8e-14 52.3 0.1 1.4 1 0 0 1 1 1 1 PITH domain OST3_OST6 PF04756.13 CCF39954.1 - 1.2e-08 34.7 0.1 2e-08 34.0 0.1 1.3 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family AhpC-TSA PF00578.21 CCF39954.1 - 6e-05 22.9 0.2 0.0002 21.3 0.1 1.8 2 0 0 2 2 2 1 AhpC/TSA family Thioredoxin_2 PF13098.6 CCF39954.1 - 9.9e-05 22.7 0.1 0.00031 21.2 0.1 1.8 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 CCF39954.1 - 0.00039 20.7 0.0 0.00075 19.8 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like Redoxin PF08534.10 CCF39954.1 - 0.0026 17.5 0.1 0.0054 16.4 0.1 1.5 1 0 0 1 1 1 1 Redoxin Thioredoxin_7 PF13899.6 CCF39954.1 - 0.01 16.0 0.0 0.02 15.1 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin-like Thioredoxin_9 PF14595.6 CCF39954.1 - 0.02 14.6 0.0 0.044 13.6 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin TraF PF13728.6 CCF39954.1 - 0.13 12.1 0.0 0.21 11.4 0.0 1.3 1 0 0 1 1 1 0 F plasmid transfer operon protein O-FucT PF10250.9 CCF39955.1 - 1.2e-16 61.4 0.0 2.7e-15 56.9 0.0 2.2 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase HET PF06985.11 CCF39956.1 - 1.1e-07 32.3 0.0 1.2e-07 32.2 0.0 1.1 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) DDE_1 PF03184.19 CCF39958.1 - 3.6e-13 49.5 0.0 1e-12 48.1 0.0 1.7 1 1 0 1 1 1 1 DDE superfamily endonuclease HTH_psq PF05225.16 CCF39958.1 - 1.5e-08 34.2 0.0 2.8e-08 33.4 0.0 1.4 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.16 CCF39958.1 - 9e-08 32.0 0.0 2.4e-07 30.7 0.0 1.7 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_23 PF13384.6 CCF39958.1 - 0.0022 17.7 0.2 0.011 15.5 0.0 2.2 2 0 0 2 2 2 1 Homeodomain-like domain CBM-like PF14683.6 CCF39959.1 - 5.8e-24 84.8 0.5 1.1e-23 83.9 0.5 1.5 1 0 0 1 1 1 1 Polysaccharide lyase family 4, domain III fn3_3 PF14686.6 CCF39959.1 - 2.4e-23 81.7 0.0 7.7e-23 80.1 0.0 2.0 1 0 0 1 1 1 1 Polysaccharide lyase family 4, domain II Big_7 PF17957.1 CCF39959.1 - 0.35 11.7 0.1 0.35 11.7 0.1 3.5 3 1 0 3 3 3 0 Bacterial Ig domain Pkinase PF00069.25 CCF39961.1 - 7e-09 35.4 0.0 3.4e-08 33.2 0.0 2.0 2 1 0 2 2 2 1 Protein kinase domain DUF908 PF06012.12 CCF39962.1 - 2.1e-123 412.3 3.9 2.7e-123 411.9 3.9 1.1 1 0 0 1 1 1 1 Domain of Unknown Function (DUF908) DUF913 PF06025.12 CCF39962.1 - 0.055 12.4 0.3 0.19 10.7 0.0 2.0 3 0 0 3 3 3 0 Domain of Unknown Function (DUF913) Exonuc_V_gamma PF04257.14 CCF39962.1 - 0.058 11.6 0.1 0.091 11.0 0.1 1.2 1 0 0 1 1 1 0 Exodeoxyribonuclease V, gamma subunit TisB_toxin PF13939.6 CCF39962.1 - 0.21 11.4 2.1 5.4 6.9 0.0 2.4 2 0 0 2 2 2 0 Toxin TisB, type I toxin-antitoxin system MFS_1 PF07690.16 CCF39963.1 - 3.2e-14 52.6 25.9 3.7e-14 52.4 25.9 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily CDC73_C PF05179.14 CCF39964.1 - 3.1e-53 179.6 0.0 3.9e-53 179.3 0.0 1.1 1 0 0 1 1 1 1 RNA pol II accessory factor, Cdc73 family, C-terminal AMP-binding PF00501.28 CCF39966.1 - 1e-51 175.9 0.0 1.4e-51 175.4 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.25 CCF39966.1 - 8.4e-13 48.5 0.0 1.8e-12 47.4 0.0 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site Condensation PF00668.20 CCF39966.1 - 9.4e-07 27.8 0.0 1.3e-06 27.4 0.0 1.1 1 0 0 1 1 1 1 Condensation domain ABC2_membrane PF01061.24 CCF39967.1 - 4.7e-64 215.7 52.4 4.1e-34 117.8 20.2 3.5 3 1 1 4 4 4 3 ABC-2 type transporter PDR_CDR PF06422.12 CCF39967.1 - 2.9e-26 91.2 0.0 2.9e-26 91.2 0.0 3.2 3 0 0 3 3 2 1 CDR ABC transporter ABC_tran PF00005.27 CCF39967.1 - 2.8e-15 57.0 0.0 4.7e-15 56.3 0.0 1.4 1 0 0 1 1 1 1 ABC transporter RsgA_GTPase PF03193.16 CCF39967.1 - 5.7e-05 23.1 0.0 0.0001 22.2 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 CCF39967.1 - 0.00052 20.4 0.1 0.001 19.5 0.1 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.6 CCF39967.1 - 0.0011 18.8 0.0 0.22 11.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system cobW PF02492.19 CCF39967.1 - 0.0041 16.7 0.5 0.0067 16.0 0.5 1.3 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_28 PF13521.6 CCF39967.1 - 0.007 16.6 0.5 0.02 15.2 0.0 2.0 2 0 0 2 2 2 1 AAA domain SMC_N PF02463.19 CCF39967.1 - 0.011 15.2 0.0 0.17 11.3 0.0 2.2 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 CCF39967.1 - 0.012 15.9 0.2 0.03 14.6 0.1 1.7 2 0 0 2 2 1 0 AAA domain TsaE PF02367.17 CCF39967.1 - 0.034 14.1 0.1 0.077 13.0 0.1 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_24 PF13479.6 CCF39967.1 - 0.036 13.8 0.1 0.1 12.3 0.1 1.7 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 CCF39967.1 - 0.039 14.1 0.0 0.077 13.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 CCF39967.1 - 0.045 13.7 0.3 0.094 12.6 0.3 1.5 1 0 0 1 1 1 0 NACHT domain MMR_HSR1 PF01926.23 CCF39967.1 - 0.049 13.7 0.2 0.1 12.7 0.2 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_18 PF13238.6 CCF39967.1 - 0.062 13.8 0.0 0.12 13.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 CCF39967.1 - 0.064 13.0 0.2 0.17 11.7 0.2 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain RecA PF00154.21 CCF39967.1 - 0.089 12.2 0.0 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 recA bacterial DNA recombination protein AAA_13 PF13166.6 CCF39967.1 - 0.14 10.7 0.2 2.3 6.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain PRK PF00485.18 CCF39967.1 - 0.17 11.6 0.2 0.29 10.9 0.2 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family AAA_17 PF13207.6 CCF39967.1 - 0.21 12.0 0.0 0.49 10.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 CCF39967.1 - 0.25 10.6 0.5 0.45 9.7 0.5 1.3 1 0 0 1 1 1 0 Zeta toxin IGPS PF00218.21 CCF39969.1 - 3.8e-95 317.9 0.0 5.7e-95 317.3 0.0 1.3 1 0 0 1 1 1 1 Indole-3-glycerol phosphate synthase PRAI PF00697.22 CCF39969.1 - 1.6e-49 168.3 0.0 7e-45 153.2 0.0 2.4 1 1 1 2 2 2 2 N-(5'phosphoribosyl)anthranilate (PRA) isomerase GATase PF00117.28 CCF39969.1 - 9.2e-05 22.3 0.0 0.00023 21.0 0.0 1.7 2 0 0 2 2 2 1 Glutamine amidotransferase class-I NanE PF04131.14 CCF39969.1 - 0.012 14.8 0.1 0.64 9.2 0.0 2.9 3 0 0 3 3 3 0 Putative N-acetylmannosamine-6-phosphate epimerase QRPTase_C PF01729.19 CCF39969.1 - 0.018 14.9 0.5 0.72 9.6 0.1 2.7 2 0 0 2 2 2 0 Quinolinate phosphoribosyl transferase, C-terminal domain FMN_dh PF01070.18 CCF39969.1 - 0.028 13.4 0.1 0.15 11.1 0.0 2.1 2 0 0 2 2 2 0 FMN-dependent dehydrogenase GGA_N-GAT PF18308.1 CCF39969.1 - 0.16 11.6 0.1 0.38 10.4 0.1 1.6 1 0 0 1 1 1 0 GGA N-GAT domain BRCT PF00533.26 CCF39970.1 - 0.0033 17.8 0.1 0.0072 16.7 0.1 1.5 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain YafQ_toxin PF15738.5 CCF39970.1 - 0.0084 16.4 0.5 0.021 15.1 0.5 1.6 1 0 0 1 1 1 1 Bacterial toxin of type II toxin-antitoxin system, YafQ PTCB-BRCT PF12738.7 CCF39970.1 - 0.0089 16.0 0.4 0.035 14.1 0.4 2.0 1 1 0 1 1 1 1 twin BRCT domain BRCT_2 PF16589.5 CCF39970.1 - 0.046 14.1 0.0 0.096 13.1 0.0 1.5 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain RTT107_BRCT_6 PF16771.5 CCF39970.1 - 0.28 11.4 3.1 0.35 11.1 2.2 1.5 1 1 0 1 1 1 0 Regulator of Ty1 transposition protein 107 BRCT domain DNA_pol3_delta2 PF13177.6 CCF39972.1 - 3.5e-11 43.2 0.1 8.2e-11 42.0 0.1 1.6 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.29 CCF39972.1 - 1.2e-06 28.9 0.2 2.8e-06 27.8 0.2 1.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CCF39972.1 - 2e-06 28.2 0.0 2.5e-05 24.6 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 CCF39972.1 - 0.00019 21.8 0.7 0.0093 16.4 0.3 2.9 2 1 0 2 2 2 1 AAA ATPase domain AAA_24 PF13479.6 CCF39972.1 - 0.00041 20.1 0.4 0.0013 18.5 0.4 1.8 1 1 0 1 1 1 1 AAA domain Rep_fac_C PF08542.11 CCF39972.1 - 0.00061 20.1 1.0 0.0014 19.0 0.0 2.1 3 0 0 3 3 3 1 Replication factor C C-terminal domain Rad17 PF03215.15 CCF39972.1 - 0.0046 16.9 0.0 0.0084 16.0 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain ABC_tran PF00005.27 CCF39972.1 - 0.01 16.4 0.0 0.021 15.3 0.0 1.5 1 0 0 1 1 1 0 ABC transporter T4SS-DNA_transf PF02534.14 CCF39972.1 - 0.083 11.7 0.1 0.2 10.4 0.0 1.6 2 0 0 2 2 2 0 Type IV secretory system Conjugative DNA transfer AAA_29 PF13555.6 CCF39972.1 - 0.19 11.5 0.1 4.1 7.2 0.0 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain Ribosomal_L16 PF00252.18 CCF39973.1 - 3.8e-33 114.3 0.6 5.2e-33 113.9 0.6 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e RFC1 PF08519.12 CCF39974.1 - 3.6e-57 192.9 0.0 1.4e-56 191.0 0.0 2.0 2 0 0 2 2 2 1 Replication factor RFC1 C terminal domain BRCT PF00533.26 CCF39974.1 - 4.1e-15 55.9 0.0 9.7e-15 54.7 0.0 1.7 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain AAA PF00004.29 CCF39974.1 - 4.9e-09 36.7 0.1 1.2e-08 35.4 0.1 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 CCF39974.1 - 4.6e-06 26.7 0.0 1.1e-05 25.5 0.0 1.5 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_22 PF13401.6 CCF39974.1 - 0.0014 18.9 0.0 0.0078 16.5 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CCF39974.1 - 0.0035 17.8 0.0 0.015 15.7 0.0 2.1 1 0 0 1 1 1 1 AAA ATPase domain DNA_pol3_delta PF06144.13 CCF39974.1 - 0.0086 15.9 0.0 0.019 14.8 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_18 PF13238.6 CCF39974.1 - 0.014 15.9 0.1 0.057 14.0 0.1 2.1 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 CCF39974.1 - 0.069 13.4 1.6 0.27 11.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain RuvB_N PF05496.12 CCF39974.1 - 0.082 12.6 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain PTCB-BRCT PF12738.7 CCF39974.1 - 0.13 12.2 0.0 0.36 10.8 0.0 1.8 1 0 0 1 1 1 0 twin BRCT domain LRR19-TM PF15176.6 CCF39975.1 - 0.012 15.6 1.0 0.018 15.1 1.0 1.3 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain CBP4 PF07960.11 CCF39976.1 - 2.7e-28 98.4 0.8 3.9e-28 97.9 0.8 1.2 1 0 0 1 1 1 1 CBP4 COQ7 PF03232.13 CCF39976.1 - 0.0034 17.2 0.0 0.0042 16.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquinone biosynthesis protein COQ7 DUF3854 PF12965.7 CCF39976.1 - 0.056 13.4 0.9 0.086 12.8 0.9 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3854) RHIM PF12721.7 CCF39977.1 - 6.2 7.4 7.1 9.9 6.7 7.1 1.3 1 0 0 1 1 1 0 RIP homotypic interaction motif ACC_epsilon PF13822.6 CCF39978.1 - 0.062 14.0 0.1 0.092 13.4 0.1 1.2 1 0 0 1 1 1 0 Acyl-CoA carboxylase epsilon subunit Fig1 PF12351.8 CCF39979.1 - 3.9e-57 193.2 2.7 3.9e-57 193.2 2.7 2.0 2 0 0 2 2 2 1 Ca2+ regulator and membrane fusion protein Fig1 SUR7 PF06687.12 CCF39979.1 - 1.8e-05 24.5 12.9 2e-05 24.3 12.3 1.4 1 1 0 1 1 1 1 SUR7/PalI family DUF898 PF05987.13 CCF39979.1 - 0.0015 17.7 10.5 0.003 16.7 10.5 1.6 1 1 0 1 1 1 1 Bacterial protein of unknown function (DUF898) Glyco_hydro_47 PF01532.20 CCF39980.1 - 3.7e-102 342.6 0.0 4.4e-102 342.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 UCH PF00443.29 CCF39981.1 - 1.1e-16 61.1 0.0 1.2e-16 61.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CCF39981.1 - 3.4e-12 46.6 0.1 4.1e-12 46.3 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase PHD PF00628.29 CCF39981.1 - 0.1 12.5 2.6 0.65 9.9 0.6 2.4 2 0 0 2 2 2 0 PHD-finger RTA1 PF04479.13 CCF39982.1 - 1.5e-54 184.7 6.5 2e-54 184.3 6.5 1.2 1 0 0 1 1 1 1 RTA1 like protein ArAE_2 PF10334.9 CCF39984.1 - 0.00064 19.6 0.0 0.0098 15.7 0.0 2.2 2 0 0 2 2 2 1 Aromatic acid exporter family member 2 MOSC PF03473.17 CCF39989.1 - 2.4e-27 95.5 0.0 3.2e-27 95.1 0.0 1.2 1 0 0 1 1 1 1 MOSC domain adh_short_C2 PF13561.6 CCF39990.1 - 1.2e-35 123.1 0.4 1.5e-35 122.9 0.4 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF39990.1 - 4.4e-28 98.1 0.3 5.4e-28 97.8 0.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase Glyco_hydro_3_C PF01915.22 CCF39991.1 - 4.3e-55 186.8 0.0 6.5e-55 186.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 CCF39991.1 - 4e-53 180.9 0.0 6.2e-53 180.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain PA14 PF07691.12 CCF39991.1 - 5.3e-15 55.5 0.0 1e-14 54.6 0.0 1.4 1 0 0 1 1 1 1 PA14 domain Fungal_trans PF04082.18 CCF39992.1 - 3.3e-07 29.6 0.2 3.6e-07 29.5 0.2 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Arabinose_trans PF04602.12 CCF39992.1 - 0.11 11.3 0.8 0.14 10.9 0.8 1.1 1 0 0 1 1 1 0 Mycobacterial cell wall arabinan synthesis protein Sugar_tr PF00083.24 CCF39993.1 - 2.1e-91 307.1 26.6 2.4e-91 306.9 26.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF39993.1 - 4.3e-20 71.9 21.9 4.3e-20 71.9 21.9 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Actin PF00022.19 CCF39994.1 - 4.6e-128 427.3 0.0 1.9e-127 425.3 0.0 1.7 1 1 0 1 1 1 1 Actin Zn_clus PF00172.18 CCF39997.1 - 2.9e-05 24.1 8.0 4.6e-05 23.5 8.0 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PSRT PF07636.11 CCF39997.1 - 0.049 13.3 0.5 0.11 12.1 0.5 1.6 1 0 0 1 1 1 0 PSRT PRCH PF03967.13 CCF39997.1 - 0.11 12.7 0.0 0.33 11.2 0.0 1.8 2 0 0 2 2 2 0 Photosynthetic reaction centre, H-chain N-terminal region NPP1 PF05630.11 CCF39998.1 - 2.4e-63 213.8 0.3 2.9e-63 213.6 0.3 1.1 1 0 0 1 1 1 1 Necrosis inducing protein (NPP1) Aldo_ket_red PF00248.21 CCF40000.1 - 3.6e-71 239.8 0.0 4e-71 239.6 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family DUF1110 PF06533.12 CCF40002.1 - 0.028 14.4 0.9 0.051 13.5 0.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1110) ZapB PF06005.12 CCF40002.1 - 0.14 12.7 1.9 19 5.8 0.3 3.2 2 1 0 2 2 2 0 Cell division protein ZapB Ustilago_mating PF05722.12 CCF40003.1 - 0.04 13.5 0.4 0.059 12.9 0.4 1.2 1 0 0 1 1 1 0 Ustilago B locus mating-type protein p450 PF00067.22 CCF40004.1 - 1.7e-29 102.9 0.0 5.1e-29 101.3 0.0 1.7 1 1 0 1 1 1 1 Cytochrome P450 AltA1 PF16541.5 CCF40006.1 - 9.6e-27 94.0 0.9 1.3e-26 93.6 0.9 1.2 1 0 0 1 1 1 1 Alternaria alternata allergen 1 DUF3095 PF11294.8 CCF40007.1 - 0.063 12.3 0.0 0.085 11.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3095) Glycos_transf_2 PF00535.26 CCF40007.1 - 0.16 11.8 0.0 0.28 11.0 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 2 ERG4_ERG24 PF01222.17 CCF40008.1 - 1.3e-24 86.7 0.0 1.5e-24 86.5 0.0 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family Peptidase_M28 PF04389.17 CCF40009.1 - 1.8e-39 135.5 0.0 3.1e-39 134.7 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 CCF40009.1 - 1.8e-11 43.9 0.3 5.3e-11 42.4 0.1 2.0 2 0 0 2 2 2 1 PA domain Peptidase_M20 PF01546.28 CCF40009.1 - 1.8e-05 24.5 0.0 3.5e-05 23.6 0.0 1.5 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 Vps51 PF08700.11 CCF40010.1 - 2.9e-14 52.9 0.0 5.7e-14 52.0 0.0 1.5 1 0 0 1 1 1 1 Vps51/Vps67 Sas10 PF09368.10 CCF40011.1 - 4.7e-30 103.9 8.5 4.7e-30 103.9 8.5 3.3 3 0 0 3 3 3 1 Sas10 C-terminal domain Sas10_Utp3 PF04000.15 CCF40011.1 - 2.6e-11 44.0 0.0 2.6e-11 44.0 0.0 3.1 2 1 0 2 2 2 1 Sas10/Utp3/C1D family zf-CpG_bind_C PF12269.8 CCF40011.1 - 0.18 11.6 5.6 0.84 9.4 5.6 2.1 1 0 0 1 1 1 0 CpG binding protein zinc finger C terminal domain adh_short PF00106.25 CCF40012.1 - 1.9e-31 109.1 0.0 2.4e-31 108.7 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF40012.1 - 7.4e-23 81.3 0.0 9.5e-23 81.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF40012.1 - 1.1e-08 35.2 0.0 1.8e-08 34.5 0.0 1.3 1 0 0 1 1 1 1 KR domain Shikimate_DH PF01488.20 CCF40012.1 - 0.002 18.2 0.1 0.0037 17.3 0.1 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 CCF40012.1 - 0.0022 18.5 0.0 0.078 13.6 0.3 2.4 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent THF_DHG_CYH_C PF02882.19 CCF40012.1 - 0.02 14.2 0.0 0.034 13.5 0.0 1.3 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain NAD_binding_10 PF13460.6 CCF40012.1 - 0.028 14.3 0.2 0.17 11.8 0.2 1.9 2 0 0 2 2 2 0 NAD(P)H-binding ApbA PF02558.16 CCF40012.1 - 0.029 14.0 0.0 0.055 13.1 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA 3HCDH_N PF02737.18 CCF40012.1 - 0.17 11.8 0.2 0.27 11.1 0.2 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Urb2 PF10441.9 CCF40013.1 - 1.2e-64 218.1 1.2 3.8e-64 216.4 1.2 2.0 1 0 0 1 1 1 1 Urb2/Npa2 family partial_CstF PF15861.5 CCF40013.1 - 0.082 12.7 0.1 0.39 10.5 0.1 2.2 1 0 0 1 1 1 0 Partial cleavage stimulation factor domain DUF543 PF04418.12 CCF40014.1 - 3e-30 104.0 0.0 3.4e-30 103.8 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF543) Fungal_trans PF04082.18 CCF40017.1 - 2.6e-09 36.5 0.0 3.9e-09 35.9 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF40017.1 - 2e-06 27.8 10.2 5.4e-06 26.4 10.2 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Hema_HEFG PF02710.14 CCF40018.1 - 0.13 12.5 0.0 0.14 12.4 0.0 1.1 1 0 0 1 1 1 0 Hemagglutinin domain of haemagglutinin-esterase-fusion glycoprotein Amino_oxidase PF01593.24 CCF40020.1 - 7.4e-29 101.3 0.4 7.9e-28 97.9 0.4 2.2 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase Mre11_DNA_bind PF04152.14 CCF40021.1 - 8.5e-38 130.3 0.2 1.2e-37 129.8 0.2 1.2 1 0 0 1 1 1 1 Mre11 DNA-binding presumed domain Metallophos PF00149.28 CCF40021.1 - 5.4e-16 59.7 2.3 9.4e-16 58.9 2.3 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CCF40021.1 - 8.5e-05 22.8 0.0 0.00077 19.7 0.0 2.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Fip1 PF05182.13 CCF40021.1 - 0.12 11.9 0.2 0.28 10.7 0.2 1.6 1 0 0 1 1 1 0 Fip1 motif LRV PF01816.17 CCF40022.1 - 0.079 13.4 0.6 0.26 11.8 0.1 2.1 2 0 0 2 2 2 0 Leucine rich repeat variant EF-hand_4 PF12763.7 CCF40024.1 - 7.5e-25 86.9 0.0 6.4e-13 48.5 0.0 2.5 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand DUF1720 PF08226.11 CCF40024.1 - 8.5e-06 26.1 57.6 7.1e-05 23.1 32.3 7.1 6 2 2 8 8 8 3 Domain of unknown function (DUF1720) EF-hand_1 PF00036.32 CCF40024.1 - 0.0066 15.9 0.0 0.83 9.4 0.0 2.5 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 CCF40024.1 - 0.11 13.0 6.0 1.8 9.1 0.0 3.3 4 0 0 4 4 4 0 EF-hand domain pair EF-hand_6 PF13405.6 CCF40024.1 - 0.15 12.0 0.0 35 4.7 0.0 3.3 3 0 0 3 3 3 0 EF-hand domain p450 PF00067.22 CCF40025.1 - 1.6e-17 63.5 0.0 1.8e-17 63.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Amidase PF01425.21 CCF40027.1 - 4.2e-30 105.1 1.6 6.9e-30 104.4 1.6 1.2 1 0 0 1 1 1 1 Amidase zf-UBR PF02207.20 CCF40028.1 - 3.6e-19 68.7 9.4 7.4e-19 67.7 9.4 1.6 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) ClpS PF02617.17 CCF40028.1 - 2.3e-09 36.9 0.0 5.6e-09 35.7 0.0 1.6 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS PS-DH PF14765.6 CCF40029.1 - 1.3e-26 93.5 0.0 1.6e-26 93.3 0.0 1.0 1 0 0 1 1 1 1 Polyketide synthase dehydratase FAD_binding_4 PF01565.23 CCF40030.1 - 2.1e-29 102.0 0.6 5.2e-29 100.8 0.4 1.7 2 0 0 2 2 2 1 FAD binding domain Hydant_A_N PF05378.13 CCF40031.1 - 1.1e-51 175.1 0.0 1.4e-51 174.7 0.0 1.1 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase N-terminal region RNase_H PF00075.24 CCF40032.1 - 2.1e-14 53.9 0.2 4.3e-14 52.9 0.2 1.5 1 0 0 1 1 1 1 RNase H zf-RVT PF13966.6 CCF40032.1 - 0.037 14.7 1.1 0.085 13.6 0.3 2.1 2 1 0 2 2 2 0 zinc-binding in reverse transcriptase COG2 PF06148.11 CCF40033.1 - 1e-24 87.1 0.0 1.6e-24 86.5 0.0 1.2 1 0 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 Vps51 PF08700.11 CCF40033.1 - 0.0018 18.3 0.0 0.0066 16.5 0.0 2.0 1 1 1 2 2 2 1 Vps51/Vps67 Spc7 PF08317.11 CCF40033.1 - 0.091 11.6 0.1 0.14 11.0 0.1 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Vps54_N PF10475.9 CCF40033.1 - 0.25 10.6 0.0 1.8 7.8 0.0 1.9 1 1 1 2 2 2 0 Vacuolar-sorting protein 54, of GARP complex CENP-B_dimeris PF09026.10 CCF40033.1 - 0.66 10.4 6.9 0.16 12.4 3.3 1.8 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Ribosomal_L1 PF00687.21 CCF40034.1 - 1.6e-09 37.8 0.0 1.8e-09 37.7 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Salt_tol_Pase PF09506.10 CCF40034.1 - 0.1 11.4 0.0 0.11 11.2 0.0 1.1 1 0 0 1 1 1 0 Glucosylglycerol-phosphate phosphatase (Salt_tol_Pase) cobW PF02492.19 CCF40035.1 - 1.8e-22 79.8 0.5 2.1e-22 79.5 0.5 1.1 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_16 PF13191.6 CCF40035.1 - 0.00086 19.7 0.0 0.00097 19.6 0.0 1.1 1 0 0 1 1 1 1 AAA ATPase domain AAA_23 PF13476.6 CCF40035.1 - 0.0033 18.0 0.1 0.0039 17.7 0.1 1.2 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 CCF40035.1 - 0.012 15.6 0.0 0.014 15.3 0.0 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea MMR_HSR1 PF01926.23 CCF40035.1 - 0.022 14.9 0.0 0.027 14.5 0.0 1.2 1 0 0 1 1 1 0 50S ribosome-binding GTPase TsaE PF02367.17 CCF40035.1 - 0.024 14.6 0.2 0.033 14.2 0.1 1.4 1 1 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_29 PF13555.6 CCF40035.1 - 0.025 14.3 0.0 0.036 13.8 0.0 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_18 PF13238.6 CCF40035.1 - 0.033 14.7 0.0 0.042 14.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 CCF40035.1 - 0.038 13.1 0.1 0.043 12.9 0.1 1.1 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_22 PF13401.6 CCF40035.1 - 0.04 14.2 0.0 0.049 13.9 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 CCF40035.1 - 0.053 13.2 0.1 0.061 13.0 0.1 1.2 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 CCF40035.1 - 0.061 13.2 0.1 0.086 12.7 0.0 1.3 1 1 0 1 1 1 0 RsgA GTPase MeaB PF03308.16 CCF40035.1 - 0.068 12.1 0.0 0.092 11.7 0.0 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ABC_tran PF00005.27 CCF40035.1 - 0.088 13.3 0.3 0.13 12.8 0.3 1.3 1 1 0 1 1 1 0 ABC transporter Zeta_toxin PF06414.12 CCF40035.1 - 0.094 12.0 0.0 0.12 11.6 0.0 1.1 1 0 0 1 1 1 0 Zeta toxin AAA_14 PF13173.6 CCF40035.1 - 0.095 12.7 0.0 0.11 12.5 0.0 1.1 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 CCF40035.1 - 0.15 11.7 0.0 0.2 11.4 0.0 1.1 1 0 0 1 1 1 0 AAA domain Mob1_phocein PF03637.17 CCF40036.1 - 3.2e-22 79.3 0.1 5.7e-22 78.5 0.1 1.3 1 0 0 1 1 1 1 Mob1/phocein family FAM209 PF15206.6 CCF40036.1 - 0.086 12.6 0.0 0.18 11.6 0.0 1.5 1 0 0 1 1 1 0 FAM209 family CxC6 PF18721.1 CCF40036.1 - 0.18 12.1 3.6 0.34 11.2 3.6 1.4 1 0 0 1 1 1 0 CxC6 like cysteine cluster associated with KDZ transposases Fungal_trans_2 PF11951.8 CCF40037.1 - 4.1e-11 42.3 2.6 1.4e-10 40.6 2.6 1.8 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF40037.1 - 5.2e-07 29.7 9.1 9.3e-07 28.9 9.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PhoD_N PF16655.5 CCF40037.1 - 0.026 15.1 0.0 0.063 13.8 0.0 1.6 1 0 0 1 1 1 0 PhoD-like phosphatase, N-terminal domain Zn_clus PF00172.18 CCF40038.1 - 1e-10 41.5 12.5 1.6e-10 40.9 12.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CCF40038.1 - 0.061 12.3 0.0 0.11 11.5 0.0 1.3 1 0 0 1 1 1 0 Fungal specific transcription factor domain SecY PF00344.20 CCF40039.1 - 2.2e-71 240.6 7.4 2.9e-71 240.3 7.4 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.9 CCF40039.1 - 3.3e-17 62.0 0.2 1e-16 60.5 0.2 1.9 1 0 0 1 1 1 1 Plug domain of Sec61p RELT PF12606.8 CCF40039.1 - 1.4 8.0 3.6 4.1 6.5 3.6 1.8 1 0 0 1 1 1 0 Tumour necrosis factor receptor superfamily member 19 IPPT PF01715.17 CCF40040.1 - 1e-25 90.9 0.0 1.2e-25 90.7 0.0 1.1 1 0 0 1 1 1 1 IPP transferase IPT PF01745.16 CCF40040.1 - 1e-05 25.1 0.0 1.1e-05 25.0 0.0 1.1 1 0 0 1 1 1 1 Isopentenyl transferase AAA_33 PF13671.6 CCF40040.1 - 0.0019 18.3 0.0 0.0022 18.1 0.0 1.1 1 0 0 1 1 1 1 AAA domain Hpr_kinase_C PF07475.12 CCF40040.1 - 0.0033 17.0 0.0 0.0044 16.6 0.0 1.1 1 0 0 1 1 1 1 HPr Serine kinase C-terminal domain RNA_helicase PF00910.22 CCF40040.1 - 0.0043 17.4 0.0 0.0087 16.4 0.0 1.6 1 1 0 1 1 1 1 RNA helicase AAA_28 PF13521.6 CCF40040.1 - 0.01 16.1 0.1 0.011 16.0 0.1 1.3 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 CCF40040.1 - 0.011 16.1 0.0 0.012 16.0 0.0 1.2 1 1 0 1 1 1 0 AAA ATPase domain AAA_5 PF07728.14 CCF40040.1 - 0.016 15.2 0.0 0.022 14.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 CCF40040.1 - 0.017 15.6 0.1 0.02 15.4 0.1 1.3 1 1 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 CCF40040.1 - 0.025 14.3 0.0 0.029 14.1 0.0 1.2 1 0 0 1 1 1 0 IstB-like ATP binding protein PhoH PF02562.16 CCF40040.1 - 0.029 13.8 0.0 0.038 13.4 0.0 1.2 1 0 0 1 1 1 0 PhoH-like protein Zeta_toxin PF06414.12 CCF40040.1 - 0.033 13.5 0.0 0.041 13.1 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin ABC_tran PF00005.27 CCF40040.1 - 0.038 14.5 0.0 0.043 14.3 0.0 1.2 1 0 0 1 1 1 0 ABC transporter AAA_22 PF13401.6 CCF40040.1 - 0.046 14.0 0.0 0.082 13.2 0.0 1.5 1 1 1 2 2 2 0 AAA domain Cytidylate_kin PF02224.18 CCF40040.1 - 0.06 13.1 0.0 0.06 13.1 0.0 1.1 1 0 0 1 1 1 0 Cytidylate kinase AAA PF00004.29 CCF40040.1 - 0.077 13.4 0.0 0.077 13.4 0.0 1.2 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF87 PF01935.17 CCF40040.1 - 0.1 12.7 0.0 0.13 12.3 0.0 1.2 1 0 0 1 1 1 0 Helicase HerA, central domain KTI12 PF08433.10 CCF40040.1 - 0.11 12.0 0.0 0.13 11.7 0.0 1.1 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_25 PF13481.6 CCF40040.1 - 0.13 11.8 0.0 0.38 10.3 0.0 1.7 2 0 0 2 2 2 0 AAA domain Sugar_tr PF00083.24 CCF40041.1 - 1.2e-25 90.3 13.3 1.4e-25 90.1 13.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF40041.1 - 1.8e-10 40.3 10.3 2.6e-10 39.8 10.3 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 CCF40041.1 - 0.0015 17.0 2.4 0.0017 16.9 2.4 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_5 PF05631.14 CCF40041.1 - 0.0043 16.0 2.5 0.0059 15.6 2.5 1.2 1 0 0 1 1 1 1 Sugar-tranasporters, 12 TM MFS_3 PF05977.13 CCF40041.1 - 0.3 9.4 4.1 0.63 8.4 4.1 1.5 1 1 0 1 1 1 0 Transmembrane secretion effector DUF3792 PF12670.7 CCF40041.1 - 0.65 10.2 15.1 0.25 11.5 8.2 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3792) DUF2530 PF10745.9 CCF40041.1 - 5.2 7.4 7.2 4.9 7.5 2.9 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2530) FR47 PF08445.10 CCF40042.1 - 4.8e-05 23.3 0.0 8.6e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_1 PF00583.25 CCF40042.1 - 0.00016 21.9 0.0 0.00029 21.0 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family DAO PF01266.24 CCF40044.1 - 1.6e-27 97.0 0.0 2.5e-26 93.1 0.0 2.0 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 CCF40044.1 - 3.4e-07 30.4 0.1 0.009 16.0 0.0 2.4 2 0 0 2 2 2 2 FAD-NAD(P)-binding Trp_halogenase PF04820.14 CCF40044.1 - 1.5e-06 27.3 0.3 0.0039 16.1 0.2 2.2 2 0 0 2 2 2 2 Tryptophan halogenase Pyr_redox_2 PF07992.14 CCF40044.1 - 5.8e-05 22.5 0.0 0.076 12.2 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCF40044.1 - 0.002 18.3 0.0 0.0062 16.7 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 CCF40044.1 - 0.0062 15.7 0.0 0.18 10.8 0.0 2.3 2 1 0 2 2 2 1 Glucose inhibited division protein A FAD_binding_3 PF01494.19 CCF40044.1 - 0.011 15.0 0.0 0.019 14.2 0.0 1.4 1 0 0 1 1 1 0 FAD binding domain Sacchrp_dh_NADP PF03435.18 CCF40044.1 - 0.017 15.4 0.0 0.044 14.0 0.0 1.7 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 CCF40044.1 - 0.02 15.0 0.0 0.033 14.2 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.18 CCF40044.1 - 0.022 15.0 0.0 0.045 14.0 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain ApbA PF02558.16 CCF40044.1 - 0.054 13.1 0.0 0.15 11.7 0.0 1.7 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA GMC_oxred_N PF00732.19 CCF40044.1 - 0.095 12.1 0.1 5.4 6.3 0.0 2.3 2 0 0 2 2 2 0 GMC oxidoreductase NAD_binding_7 PF13241.6 CCF40044.1 - 0.1 13.1 0.0 0.19 12.2 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding Thi4 PF01946.17 CCF40044.1 - 0.15 11.3 0.0 0.29 10.3 0.0 1.4 1 0 0 1 1 1 0 Thi4 family MFS_1 PF07690.16 CCF40045.1 - 1.2e-06 27.7 8.6 1.2e-06 27.7 8.6 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily Popeye PF04831.13 CCF40046.1 - 0.15 12.2 2.7 0.16 12.1 2.7 1.2 1 0 0 1 1 1 0 Popeye protein conserved region CAP_GLY PF01302.25 CCF40047.1 - 3.8e-25 87.7 0.6 6e-25 87.1 0.6 1.3 1 0 0 1 1 1 1 CAP-Gly domain Pyr_redox_2 PF07992.14 CCF40049.1 - 9e-16 58.0 0.0 1.3e-10 41.0 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCF40049.1 - 6e-06 25.7 0.0 0.0035 16.7 0.0 2.8 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 CCF40049.1 - 2e-05 23.9 0.1 0.0018 17.4 0.1 2.2 2 0 0 2 2 2 1 Lycopene cyclase protein K_oxygenase PF13434.6 CCF40049.1 - 0.00011 21.5 0.1 0.066 12.4 0.0 2.2 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.14 CCF40049.1 - 0.00017 20.4 0.3 0.003 16.3 0.0 2.1 2 0 0 2 2 2 1 HI0933-like protein GIDA PF01134.22 CCF40049.1 - 0.00062 19.0 1.2 0.21 10.6 0.1 2.2 1 1 1 2 2 2 2 Glucose inhibited division protein A FAD_binding_2 PF00890.24 CCF40049.1 - 0.00067 18.8 0.1 0.0074 15.4 0.0 2.2 2 0 0 2 2 2 1 FAD binding domain NAD_binding_9 PF13454.6 CCF40049.1 - 0.0011 19.0 1.0 1.3 9.0 0.2 2.5 2 0 0 2 2 2 2 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 CCF40049.1 - 0.0027 17.9 0.1 0.0065 16.7 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CCF40049.1 - 0.004 16.8 2.6 0.016 14.8 0.7 2.2 1 1 1 2 2 2 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 CCF40049.1 - 0.025 13.9 0.1 0.04 13.2 0.1 1.3 1 0 0 1 1 1 0 FAD binding domain Thi4 PF01946.17 CCF40049.1 - 0.057 12.6 0.1 0.13 11.5 0.1 1.5 2 0 0 2 2 2 0 Thi4 family Lipase_GDSL_2 PF13472.6 CCF40051.1 - 1.8e-23 83.9 3.7 3.1e-23 83.1 3.7 1.4 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 CCF40051.1 - 7.6e-10 39.1 0.0 1.3e-09 38.4 0.0 1.4 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase GATA PF00320.27 CCF40053.1 - 1.8e-16 59.4 2.3 3.6e-16 58.5 2.3 1.5 1 0 0 1 1 1 1 GATA zinc finger DUF1752 PF08550.10 CCF40053.1 - 1.7e-11 43.7 0.3 3.6e-11 42.7 0.3 1.5 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) p450 PF00067.22 CCF40055.1 - 1.7e-10 40.2 0.6 3.6e-09 35.9 0.6 2.3 1 1 0 1 1 1 1 Cytochrome P450 TauD PF02668.16 CCF40056.1 - 7.1e-30 104.7 1.6 1e-29 104.2 1.6 1.3 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family CsiD PF08943.10 CCF40056.1 - 0.0097 15.0 0.0 0.016 14.3 0.0 1.2 1 0 0 1 1 1 1 CsiD AA_permease_2 PF13520.6 CCF40057.1 - 2.7e-70 237.3 38.8 3.5e-70 237.0 38.8 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CCF40057.1 - 7.5e-17 61.1 34.1 1.1e-16 60.5 34.1 1.2 1 0 0 1 1 1 1 Amino acid permease TMEM237 PF15383.6 CCF40057.1 - 0.1 11.7 0.3 0.23 10.5 0.3 1.5 1 0 0 1 1 1 0 Transmembrane protein 237 YCII PF03795.14 CCF40058.1 - 0.047 14.1 0.0 0.056 13.9 0.0 1.1 1 0 0 1 1 1 0 YCII-related domain Pectate_lyase PF03211.13 CCF40060.1 - 2.4e-70 236.2 0.4 3.2e-70 235.8 0.4 1.0 1 0 0 1 1 1 1 Pectate lyase DUF3328 PF11807.8 CCF40062.1 - 8.5e-49 166.3 0.7 1.1e-48 165.9 0.7 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Y_phosphatase PF00102.27 CCF40064.1 - 1.7e-12 47.4 0.0 2.1e-12 47.1 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase MARVEL PF01284.23 CCF40065.1 - 1.2e-18 67.5 13.5 1.5e-18 67.2 13.5 1.1 1 0 0 1 1 1 1 Membrane-associating domain Solute_trans_a PF03619.16 CCF40065.1 - 0.02 14.4 1.4 0.039 13.5 1.4 1.5 1 1 0 1 1 1 0 Organic solute transporter Ostalpha ABC2_membrane_5 PF13346.6 CCF40065.1 - 0.35 10.4 7.1 0.5 9.9 7.1 1.4 1 1 0 1 1 1 0 ABC-2 family transporter protein PAP2 PF01569.21 CCF40065.1 - 4 7.2 11.0 1.2 8.9 7.4 1.8 2 0 0 2 2 2 0 PAP2 superfamily DUF924 PF06041.11 CCF40066.1 - 2.9e-32 112.2 0.1 3.7e-32 111.9 0.1 1.1 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF924) Glyco_hydro_11 PF00457.17 CCF40067.1 - 3.7e-62 209.1 14.6 4.5e-62 208.8 14.6 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 11 MFS_1 PF07690.16 CCF40068.1 - 6.6e-39 133.8 59.2 1.9e-32 112.6 46.1 3.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 CCF40068.1 - 3.4e-13 48.9 27.9 4.8e-13 48.4 27.9 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF412 PF04217.13 CCF40068.1 - 0.1 12.5 2.4 6.9 6.6 0.1 3.2 3 1 0 3 3 3 0 Protein of unknown function, DUF412 Cytochrome_C7 PF14522.6 CCF40071.1 - 0.026 14.5 0.0 0.027 14.5 0.0 1.1 1 0 0 1 1 1 0 Cytochrome c7 and related cytochrome c Gmx_para_CXXCG PF09535.10 CCF40071.1 - 0.047 13.0 4.3 1 8.6 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (Gmx_para_CXXCG) Ebp2 PF05890.12 CCF40072.1 - 1.9e-88 296.5 14.1 1.9e-88 296.5 14.1 2.9 2 1 0 2 2 2 1 Eukaryotic rRNA processing protein EBP2 Fic PF02661.18 CCF40073.1 - 2e-19 70.3 0.0 4.4e-19 69.2 0.0 1.6 1 0 0 1 1 1 1 Fic/DOC family McrBC PF10117.9 CCF40073.1 - 0.086 12.0 0.0 0.11 11.7 0.0 1.2 1 0 0 1 1 1 0 McrBC 5-methylcytosine restriction system component CP2 PF04516.15 CCF40075.1 - 6e-87 290.8 0.0 8.5e-87 290.2 0.0 1.2 1 0 0 1 1 1 1 CP2 transcription factor Tektin PF03148.14 CCF40075.1 - 0.04 12.7 0.0 0.062 12.0 0.0 1.2 1 0 0 1 1 1 0 Tektin family TMF_DNA_bd PF12329.8 CCF40075.1 - 0.07 13.1 0.5 0.15 12.0 0.5 1.5 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding Glyco_tranf_2_3 PF13641.6 CCF40077.1 - 1.4e-15 57.8 0.5 1.9e-15 57.4 0.5 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 CCF40077.1 - 0.0015 18.3 0.0 0.0028 17.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 SSF PF00474.17 CCF40078.1 - 1e-16 60.8 34.9 1.6e-16 60.2 33.3 1.9 2 0 0 2 2 2 1 Sodium:solute symporter family p450 PF00067.22 CCF40080.1 - 2.2e-37 128.9 0.0 3.7e-36 124.9 0.0 2.0 2 0 0 2 2 2 2 Cytochrome P450 HpaB PF03241.13 CCF40080.1 - 0.087 11.9 0.0 1.6 7.8 0.0 2.1 2 0 0 2 2 2 0 4-hydroxyphenylacetate 3-hydroxylase C terminal Orthopox_A36R PF05950.11 CCF40082.1 - 1.4 9.0 6.7 2.7 8.1 6.7 1.4 1 0 0 1 1 1 0 Orthopoxvirus A36R protein DTHCT PF08070.11 CCF40082.1 - 6.8 7.5 23.2 5 7.9 20.3 2.0 1 1 1 2 2 2 0 DTHCT (NUC029) region Acetyltransf_3 PF13302.7 CCF40084.1 - 0.13 12.9 0.0 0.16 12.6 0.0 1.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain stn_TNFRSF12A PF12191.8 CCF40085.1 - 0.023 14.9 0.1 0.049 13.9 0.1 1.5 1 0 0 1 1 1 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain Cadherin_C_2 PF16492.5 CCF40086.1 - 0.47 11.2 3.6 0.48 11.2 2.1 1.9 2 1 0 2 2 2 0 Cadherin cytoplasmic C-terminal RskA PF10099.9 CCF40088.1 - 0.016 15.5 0.7 0.018 15.4 0.7 1.0 1 0 0 1 1 1 0 Anti-sigma-K factor rskA Baculo_11_kDa PF06143.11 CCF40089.1 - 2 8.0 4.9 2.6 7.7 1.7 2.7 2 0 0 2 2 2 0 Baculovirus 11 kDa family HABP4_PAI-RBP1 PF04774.15 CCF40089.1 - 2.8 8.8 10.3 0.22 12.3 4.9 1.9 2 0 0 2 2 2 0 Hyaluronan / mRNA binding family Ribosomal_L13e PF01294.18 CCF40091.1 - 7.7e-73 244.2 1.6 1.1e-72 243.6 1.6 1.2 1 0 0 1 1 1 1 Ribosomal protein L13e MCM2_N PF12619.8 CCF40091.1 - 0.0047 17.2 2.1 0.018 15.3 2.4 1.8 2 0 0 2 2 2 1 Mini-chromosome maintenance protein 2 GP68 PF17469.2 CCF40092.1 - 0.11 12.9 0.1 12 6.4 0.0 2.3 2 0 0 2 2 2 0 Phage protein Gp68 PS-DH PF14765.6 CCF40093.1 - 1.5e-48 165.6 0.0 2.8e-48 164.7 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 CCF40093.1 - 2.4e-11 43.7 0.0 4.9e-11 42.7 0.0 1.5 2 0 0 2 2 2 1 Acyl transferase domain 2OG-FeII_Oxy_3 PF13640.6 CCF40094.1 - 1.4e-07 32.3 0.0 2.1e-07 31.7 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF621 PF04789.15 CCF40094.1 - 0.028 13.6 0.2 0.038 13.1 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF621) HTH_psq PF05225.16 CCF40095.1 - 7.1e-09 35.3 0.0 1.2e-08 34.5 0.0 1.4 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.16 CCF40095.1 - 2.8e-08 33.7 0.0 7.8e-08 32.2 0.0 1.7 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_23 PF13384.6 CCF40095.1 - 0.0013 18.4 0.1 0.0048 16.7 0.0 1.9 2 0 0 2 2 2 1 Homeodomain-like domain DDE_1 PF03184.19 CCF40095.1 - 0.0037 16.9 0.0 0.0094 15.6 0.0 1.6 2 0 0 2 2 2 1 DDE superfamily endonuclease DPM2 PF07297.12 CCF40096.1 - 1.7e-18 66.7 0.0 1.9e-18 66.5 0.0 1.0 1 0 0 1 1 1 1 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) DUF4229 PF14012.6 CCF40096.1 - 0.0019 18.3 0.2 0.0022 18.1 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF4229) LapA_dom PF06305.11 CCF40096.1 - 0.0022 17.8 0.2 0.0028 17.4 0.2 1.2 1 0 0 1 1 1 1 Lipopolysaccharide assembly protein A domain Asparaginase_2 PF01112.18 CCF40098.1 - 7.5e-44 150.0 2.4 5.8e-28 97.8 0.0 2.2 2 0 0 2 2 2 2 Asparaginase Tfb4 PF03850.14 CCF40099.1 - 2.7e-47 161.6 1.3 3.2e-47 161.3 1.3 1.1 1 0 0 1 1 1 1 Transcription factor Tfb4 BCMA-Tall_bind PF09257.10 CCF40102.1 - 0.089 12.9 0.1 0.15 12.2 0.1 1.4 1 0 0 1 1 1 0 BCMA, TALL-1 binding FeS_assembly_P PF01883.19 CCF40104.1 - 3e-07 30.5 0.1 2.1e-06 27.8 0.1 2.2 1 1 0 1 1 1 1 Iron-sulfur cluster assembly protein Thioredoxin PF00085.20 CCF40105.1 - 5.4e-25 87.4 0.0 7.6e-25 86.9 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 CCF40105.1 - 5.3e-07 30.1 0.1 1.8e-06 28.3 0.1 1.9 1 1 0 1 1 1 1 Thioredoxin-like domain OST3_OST6 PF04756.13 CCF40105.1 - 9.4e-07 28.5 0.2 3.6e-06 26.6 0.0 1.7 1 1 0 2 2 2 1 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 CCF40105.1 - 2e-06 28.0 0.0 1.9e-05 24.9 0.0 2.0 1 1 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.21 CCF40105.1 - 2.4e-05 24.2 0.0 3.6e-05 23.7 0.0 1.5 1 1 0 1 1 1 1 AhpC/TSA family Thioredoxin_7 PF13899.6 CCF40105.1 - 3.4e-05 24.0 0.1 5e-05 23.4 0.1 1.2 1 0 0 1 1 1 1 Thioredoxin-like Redoxin PF08534.10 CCF40105.1 - 9.5e-05 22.1 0.1 0.00015 21.5 0.1 1.3 1 1 0 1 1 1 1 Redoxin HyaE PF07449.11 CCF40105.1 - 0.00014 21.8 0.0 0.0002 21.3 0.0 1.2 1 0 0 1 1 1 1 Hydrogenase-1 expression protein HyaE TraF PF13728.6 CCF40105.1 - 0.00024 21.0 0.0 0.00035 20.5 0.0 1.2 1 0 0 1 1 1 1 F plasmid transfer operon protein Thioredoxin_9 PF14595.6 CCF40105.1 - 0.003 17.3 0.0 0.0039 17.0 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin PTR2 PF00854.21 CCF40105.1 - 0.031 13.1 0.0 0.034 13.0 0.0 1.1 1 0 0 1 1 1 0 POT family Thioredoxin_5 PF13743.6 CCF40105.1 - 0.1 12.3 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin Pkinase PF00069.25 CCF40108.1 - 4.3e-78 262.3 0.0 5.1e-78 262.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF40108.1 - 4.5e-38 131.0 0.0 6e-38 130.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 CCF40108.1 - 0.001 18.1 0.0 0.011 14.6 0.0 2.1 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 CCF40108.1 - 0.011 15.1 0.1 0.019 14.3 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CCF40108.1 - 0.021 14.7 0.1 0.068 13.1 0.1 1.8 1 1 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.6 CCF40108.1 - 0.051 12.9 0.1 0.13 11.5 0.1 1.7 1 1 1 2 2 2 0 Kinase-like Acyltransferase PF01553.21 CCF40109.1 - 0.00077 19.1 0.0 0.0011 18.5 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase ERCC4 PF02732.15 CCF40111.1 - 6.4e-20 71.9 0.0 2e-19 70.3 0.0 1.9 2 0 0 2 2 2 1 ERCC4 domain Abhydro_lipase PF04083.16 CCF40112.1 - 5.5e-20 70.7 0.0 1.1e-19 69.7 0.0 1.6 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.20 CCF40112.1 - 4.8e-06 26.4 0.0 1.5e-05 24.8 0.0 1.7 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CCF40112.1 - 0.0062 15.8 0.0 0.044 13.1 0.0 2.0 2 0 0 2 2 2 1 Serine aminopeptidase, S33 MFS_1 PF07690.16 CCF40113.1 - 1.8e-25 89.6 21.0 3.1e-25 88.9 21.0 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily DnaA_N PF11638.8 CCF40113.1 - 0.087 12.6 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 DnaA N-terminal domain DUF2892 PF11127.8 CCF40113.1 - 2.6 8.2 5.9 1.3 9.1 2.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2892) Sortilin-Vps10 PF15902.5 CCF40114.1 - 8.2e-154 512.7 11.8 1.1e-153 512.3 11.8 1.1 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 CCF40114.1 - 2.3e-61 207.1 29.3 5.1e-44 150.6 7.5 3.2 3 0 0 3 3 3 2 Sortilin, neurotensin receptor 3, C-terminal preSET_CXC PF18264.1 CCF40114.1 - 0.21 12.1 8.0 3.4 8.2 0.7 2.9 2 0 0 2 2 2 0 CXC domain BNR PF02012.20 CCF40114.1 - 0.65 10.2 35.3 1.1 9.5 0.8 6.5 7 0 0 7 7 7 0 BNR/Asp-box repeat CHB_HEX_C PF03174.13 CCF40114.1 - 6.2 6.9 5.4 1.6 8.8 0.1 2.9 4 0 0 4 4 4 0 Chitobiase/beta-hexosaminidase C-terminal domain Cyclin PF08613.11 CCF40115.1 - 2e-09 38.0 0.0 3.3e-09 37.3 0.0 1.4 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 CCF40115.1 - 0.06 13.1 0.0 0.1 12.4 0.0 1.4 1 0 0 1 1 1 0 Cyclin, N-terminal domain Galactosyl_T PF01762.21 CCF40116.1 - 2.8e-13 50.1 0.6 2.2e-12 47.2 0.6 2.0 1 1 0 1 1 1 1 Galactosyltransferase DUF4131 PF13567.6 CCF40116.1 - 0.064 12.9 0.0 0.1 12.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) Malic_M PF03949.15 CCF40117.1 - 1.3e-88 296.6 0.0 1.7e-88 296.2 0.0 1.1 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 CCF40117.1 - 1.1e-64 217.5 0.0 1.7e-64 217.0 0.0 1.2 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain COesterase PF00135.28 CCF40118.1 - 7.9e-93 312.0 0.0 9.8e-93 311.7 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CCF40118.1 - 6.4e-08 32.7 0.2 3.1e-07 30.5 0.1 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Pantoate_transf PF02548.15 CCF40118.1 - 0.11 11.9 0.0 0.17 11.2 0.0 1.2 1 0 0 1 1 1 0 Ketopantoate hydroxymethyltransferase MFS_1 PF07690.16 CCF40119.1 - 9e-34 116.9 33.4 1.1e-33 116.7 33.4 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 CCF40119.1 - 4.4e-05 22.9 21.9 0.00032 20.1 8.5 2.5 2 1 1 3 3 3 2 Uncharacterised MFS-type transporter YbfB Ribosomal_S21e PF01249.18 CCF40120.1 - 1.2e-40 137.4 0.1 1.4e-40 137.3 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S21e Glyco_hydro2_C5 PF18565.1 CCF40120.1 - 0.026 14.4 0.0 0.032 14.1 0.0 1.2 1 0 0 1 1 1 0 Glycoside hydrolase family 2 C-terminal domain 5 Haem_oxygenas_2 PF14518.6 CCF40120.1 - 0.1 12.4 0.0 0.11 12.3 0.0 1.1 1 0 0 1 1 1 0 Iron-containing redox enzyme Slx4 PF09494.10 CCF40121.1 - 8.5e-24 83.3 0.0 1.9e-23 82.2 0.0 1.6 2 0 0 2 2 2 1 Slx4 endonuclease His_biosynth PF00977.21 CCF40125.1 - 1.6e-32 112.8 0.0 6.8e-32 110.8 0.0 1.8 1 1 0 1 1 1 1 Histidine biosynthesis protein Dus PF01207.17 CCF40125.1 - 0.012 14.8 0.0 0.018 14.2 0.0 1.2 1 0 0 1 1 1 0 Dihydrouridine synthase (Dus) SAP PF02037.27 CCF40125.1 - 0.14 11.9 0.0 0.22 11.3 0.0 1.3 1 0 0 1 1 1 0 SAP domain ODC_AZ PF02100.17 CCF40126.1 - 2.7e-44 149.8 0.3 3.8e-44 149.3 0.3 1.2 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme U-box PF04564.15 CCF40127.1 - 3.3e-18 65.6 0.0 6.2e-18 64.7 0.0 1.5 1 0 0 1 1 1 1 U-box domain TPR_2 PF07719.17 CCF40127.1 - 1.4e-09 37.4 5.0 0.00014 21.7 0.2 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 CCF40127.1 - 5.5e-08 32.4 5.1 6.5e-07 28.9 0.5 2.7 2 1 0 2 2 2 1 TPR repeat TPR_19 PF14559.6 CCF40127.1 - 1.2e-07 32.1 4.4 0.0011 19.4 0.6 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 CCF40127.1 - 2.5e-07 30.2 3.9 0.0084 15.9 0.2 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 CCF40127.1 - 2.8e-07 31.0 6.7 0.00021 21.9 0.3 2.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 CCF40127.1 - 3e-06 27.2 1.9 0.038 14.4 0.1 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 CCF40127.1 - 9.4e-06 26.0 1.0 0.0049 17.6 0.1 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 CCF40127.1 - 0.00035 20.7 0.1 0.001 19.1 0.1 1.8 1 1 0 1 1 1 1 Tetratricopeptide repeat ANAPC3 PF12895.7 CCF40127.1 - 0.0038 17.4 1.7 0.016 15.4 1.5 2.1 1 1 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 CCF40127.1 - 0.0066 16.7 6.4 1.9 8.8 0.8 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 CCF40127.1 - 0.028 14.6 3.5 2.7 8.4 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 CCF40127.1 - 0.044 13.7 0.1 0.044 13.7 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 CCF40127.1 - 0.052 13.6 0.5 2.6 8.3 0.0 3.4 2 1 1 3 3 3 0 Tetratricopeptide repeat Herpes_UL87 PF03043.14 CCF40127.1 - 0.063 11.8 0.1 0.092 11.2 0.0 1.3 1 1 0 1 1 1 0 Herpesvirus UL87 family C_Hendra PF16821.5 CCF40127.1 - 0.13 12.1 3.7 0.24 11.3 3.7 1.4 1 0 0 1 1 1 0 C protein from hendra and measles viruses CHIP_TPR_N PF18391.1 CCF40127.1 - 0.29 11.9 12.8 0.69 10.7 12.8 1.7 1 1 0 1 1 1 0 CHIP N-terminal tetratricopeptide repeat domain TPR_6 PF13174.6 CCF40127.1 - 0.82 10.4 3.7 22 5.9 0.9 3.4 3 0 0 3 3 2 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 CCF40127.1 - 2.3 8.4 5.4 2.1 8.5 0.4 3.3 4 1 1 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat Glyco_hydro_10 PF00331.20 CCF40129.1 - 2.2e-80 270.2 0.0 2.6e-80 269.9 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 Glyco_hydro_42 PF02449.15 CCF40129.1 - 0.065 12.6 0.1 0.13 11.5 0.0 1.4 2 0 0 2 2 2 0 Beta-galactosidase HTH_42 PF06224.12 CCF40129.1 - 0.078 12.5 0.1 0.11 12.0 0.1 1.2 1 0 0 1 1 1 0 Winged helix DNA-binding domain CENP-L PF13092.6 CCF40130.1 - 4.9e-57 192.7 0.0 1.9e-56 190.7 0.0 1.8 2 0 0 2 2 2 1 Kinetochore complex Sim4 subunit Fta1 TFIID_NTD2 PF04494.15 CCF40132.1 - 1.6e-40 138.4 1.2 2.3e-40 137.9 1.2 1.2 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit, NTD2 domain WD40 PF00400.32 CCF40132.1 - 6.2e-40 134.5 27.2 9.2e-08 32.6 0.3 6.9 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF40132.1 - 6.1e-11 42.5 1.2 0.037 14.3 0.0 5.3 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain LisH PF08513.11 CCF40132.1 - 2.8e-06 27.1 0.0 6.2e-06 26.0 0.0 1.6 1 0 0 1 1 1 1 LisH Nucleoporin_N PF08801.11 CCF40132.1 - 3.1e-05 22.9 0.1 0.71 8.6 0.0 3.8 2 2 1 3 3 3 3 Nup133 N terminal like eIF2A PF08662.11 CCF40132.1 - 5.2e-05 23.2 0.1 0.055 13.3 0.0 3.3 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 CCF40132.1 - 0.00039 19.2 0.7 0.06 12.0 0.1 3.1 1 1 0 2 2 2 1 Nucleoporin Nup120/160 RAB3GAP2_N PF14655.6 CCF40132.1 - 0.00052 19.4 0.0 0.52 9.5 0.0 2.7 2 1 1 3 3 3 2 Rab3 GTPase-activating protein regulatory subunit N-terminus AsnC_trans_reg PF01037.21 CCF40132.1 - 0.083 12.9 0.1 0.52 10.3 0.0 2.3 2 0 0 2 2 2 0 Lrp/AsnC ligand binding domain Ribul_P_3_epim PF00834.19 CCF40133.1 - 2.5e-32 111.9 0.1 9.6e-32 110.0 0.1 1.8 1 1 0 1 1 1 1 Ribulose-phosphate 3 epimerase family ThiG PF05690.14 CCF40133.1 - 0.0085 15.4 0.2 0.011 15.1 0.2 1.1 1 0 0 1 1 1 1 Thiazole biosynthesis protein ThiG QRPTase_C PF01729.19 CCF40133.1 - 0.011 15.5 0.0 0.015 15.0 0.0 1.2 1 0 0 1 1 1 0 Quinolinate phosphoribosyl transferase, C-terminal domain OMPdecase PF00215.24 CCF40133.1 - 0.025 14.2 0.0 0.034 13.7 0.0 1.2 1 0 0 1 1 1 0 Orotidine 5'-phosphate decarboxylase / HUMPS family Aminotran_5 PF00266.19 CCF40134.1 - 1.5e-53 182.1 0.0 3.8e-53 180.8 0.0 1.6 1 1 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 CCF40134.1 - 0.00012 20.7 0.0 0.00018 20.2 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 CCF40134.1 - 0.0086 15.3 0.0 0.013 14.7 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II 2OG-FeII_Oxy_4 PF13661.6 CCF40135.1 - 8.7e-08 32.7 0.0 1.6e-07 31.9 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.6 CCF40135.1 - 0.0045 17.8 0.0 0.0071 17.2 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily SNO PF01174.19 CCF40137.1 - 6e-47 159.9 0.0 2.1e-45 154.9 0.0 2.0 1 1 0 1 1 1 1 SNO glutamine amidotransferase family GATase_3 PF07685.14 CCF40137.1 - 1.5e-07 31.2 0.0 4.5e-07 29.7 0.0 1.7 2 0 0 2 2 2 1 CobB/CobQ-like glutamine amidotransferase domain Peptidase_S51 PF03575.17 CCF40137.1 - 0.00012 21.8 0.0 0.00018 21.2 0.0 1.2 1 0 0 1 1 1 1 Peptidase family S51 DJ-1_PfpI PF01965.24 CCF40137.1 - 0.00018 21.3 0.0 0.00038 20.3 0.0 1.4 1 0 0 1 1 1 1 DJ-1/PfpI family GATase PF00117.28 CCF40137.1 - 0.00032 20.5 0.0 0.58 9.9 0.0 2.1 2 0 0 2 2 2 2 Glutamine amidotransferase class-I DUF2457 PF10446.9 CCF40138.1 - 3.1e-184 613.5 28.5 3.1e-184 613.5 28.5 2.9 2 1 1 3 3 3 1 Protein of unknown function (DUF2457) TFIIA PF03153.13 CCF40138.1 - 0.00049 20.2 20.7 0.00085 19.4 20.7 1.4 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit SDA1 PF05285.12 CCF40138.1 - 0.19 11.1 27.1 0.4 10.0 27.1 1.5 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 CCF40138.1 - 0.4 8.9 26.9 0.71 8.0 26.9 1.3 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 CCF40138.1 - 1.7 6.9 23.8 0.33 9.2 19.4 1.8 2 0 0 2 2 2 0 CDC45-like protein SURF2 PF05477.11 CCF40138.1 - 8.3 6.0 10.5 19 4.9 10.5 1.6 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) Arf PF00025.21 CCF40139.1 - 5.2e-50 169.3 0.0 6.4e-50 169.0 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 CCF40139.1 - 6.5e-09 35.4 0.0 1.1e-08 34.7 0.0 1.3 1 0 0 1 1 1 1 G-protein alpha subunit Ras PF00071.22 CCF40139.1 - 0.00014 21.5 0.0 0.00019 21.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCF40139.1 - 0.00052 20.2 0.0 0.00068 19.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 CCF40139.1 - 0.0097 15.4 0.0 0.013 15.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 CCF40139.1 - 0.06 12.9 0.0 0.068 12.7 0.0 1.1 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 CCF40139.1 - 0.072 13.2 0.0 0.099 12.7 0.0 1.2 1 0 0 1 1 1 0 50S ribosome-binding GTPase DUF3336 PF11815.8 CCF40140.1 - 1.3e-52 177.1 3.1 2.2e-52 176.4 3.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.22 CCF40140.1 - 2.3e-20 73.7 0.0 7.5e-18 65.4 0.0 2.8 2 1 0 2 2 2 2 Patatin-like phospholipase DnaJ PF00226.31 CCF40141.1 - 6.4e-16 58.2 1.5 2.4e-15 56.4 1.5 2.0 1 1 0 1 1 1 1 DnaJ domain MCR_D PF02505.14 CCF40141.1 - 0.031 14.1 0.4 0.084 12.7 0.1 1.7 2 0 0 2 2 2 0 Methyl-coenzyme M reductase operon protein D Rax2 PF12768.7 CCF40141.1 - 0.17 11.3 0.2 0.36 10.3 0.2 1.4 1 1 0 1 1 1 0 Cortical protein marker for cell polarity Fungal_trans PF04082.18 CCF40142.1 - 3.3e-29 101.7 0.0 5.5e-29 101.0 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF40142.1 - 6.2e-09 35.8 9.5 9.9e-09 35.2 9.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ArAE_1_C PF11728.8 CCF40142.1 - 0.21 11.6 0.2 1.8 8.6 0.1 2.1 2 0 0 2 2 2 0 Putative aromatic acid exporter C-terminal domain SUIM_assoc PF16619.5 CCF40142.1 - 0.52 10.4 9.7 17 5.6 0.0 2.8 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 SGL PF08450.12 CCF40145.1 - 0.025 14.2 0.0 0.34 10.5 0.0 2.3 2 1 0 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region RCC1_2 PF13540.6 CCF40145.1 - 0.25 11.2 2.4 4.3 7.3 0.5 2.5 2 0 0 2 2 2 0 Regulator of chromosome condensation (RCC1) repeat GFA PF04828.14 CCF40146.1 - 1.7e-08 34.7 8.7 2.9e-06 27.5 0.1 2.9 3 1 0 3 3 3 2 Glutathione-dependent formaldehyde-activating enzyme zf-NADH-PPase PF09297.11 CCF40146.1 - 0.014 15.0 0.1 0.014 15.0 0.1 3.0 4 0 0 4 4 4 0 NADH pyrophosphatase zinc ribbon domain Nudix_N_2 PF14803.6 CCF40146.1 - 0.015 15.2 3.6 1.5 8.8 0.1 3.4 3 0 0 3 3 3 0 Nudix N-terminal 2OG-FeII_Oxy_2 PF13532.6 CCF40147.1 - 4.8e-37 128.0 0.0 6.9e-37 127.5 0.0 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily zf-GRF PF06839.12 CCF40147.1 - 1.5e-10 41.0 7.2 3e-10 40.0 7.2 1.5 1 0 0 1 1 1 1 GRF zinc finger WD40 PF00400.32 CCF40148.1 - 2.9e-17 62.7 10.9 0.00064 20.5 0.0 6.7 6 1 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF40148.1 - 0.00014 22.1 0.1 0.28 11.5 0.0 3.8 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 CCF40148.1 - 0.023 14.7 0.0 0.3 11.1 0.0 2.6 3 0 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region DEAD PF00270.29 CCF40149.1 - 7.9e-42 143.0 0.0 1.7e-41 141.9 0.0 1.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF40149.1 - 1.1e-21 77.2 0.0 2.6e-21 76.1 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 CCF40149.1 - 0.00088 18.6 0.0 0.0015 17.8 0.0 1.2 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase ResIII PF04851.15 CCF40149.1 - 0.014 15.4 0.0 0.024 14.6 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_22 PF13401.6 CCF40149.1 - 0.054 13.8 0.0 0.17 12.2 0.0 1.8 1 1 0 1 1 1 0 AAA domain DUF4531 PF15041.6 CCF40154.1 - 0.19 11.8 0.0 0.3 11.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4531) Mito_carr PF00153.27 CCF40155.1 - 1.1e-59 198.4 3.8 1.7e-23 82.3 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 CCF40155.1 - 2.9e-05 23.3 0.3 0.0028 16.9 0.0 2.9 2 1 1 3 3 3 2 Gammaproteobacterial serine protease Ribosomal_L18 PF17135.4 CCF40156.1 - 6.5e-93 309.3 3.0 7.3e-93 309.2 3.0 1.0 1 0 0 1 1 1 1 Ribosomal protein 60S L18 and 50S L18e Ribosomal_L27A PF00828.19 CCF40156.1 - 0.003 18.2 0.1 0.003 18.2 0.1 2.0 2 1 0 2 2 2 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A FtsJ PF01728.19 CCF40157.1 - 4.5e-20 72.5 0.1 5.3e-20 72.3 0.1 1.0 1 0 0 1 1 1 1 FtsJ-like methyltransferase 7tm_2 PF00002.24 CCF40159.1 - 3.9e-08 32.9 10.9 3.9e-08 32.9 10.9 1.8 2 0 0 2 2 2 1 7 transmembrane receptor (Secretin family) Dicty_CAR PF05462.11 CCF40159.1 - 6.8e-07 28.7 8.4 6.8e-07 28.7 8.4 1.9 2 0 0 2 2 2 1 Slime mold cyclic AMP receptor Git3 PF11710.8 CCF40159.1 - 2.9e-06 27.2 8.4 4.8e-06 26.5 8.4 1.3 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 ADH_zinc_N PF00107.26 CCF40160.1 - 2.3e-11 43.8 0.0 5e-11 42.7 0.0 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCF40160.1 - 9.7e-08 31.9 0.2 2.5e-07 30.5 0.2 1.6 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 CCF40160.1 - 0.005 17.9 0.0 0.011 16.8 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Plant_vir_prot PF01307.17 CCF40160.1 - 0.068 13.4 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 Plant viral movement protein NmrA PF05368.13 CCF40161.1 - 1.6e-24 86.7 0.6 2e-24 86.5 0.6 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CCF40161.1 - 4.3e-17 62.6 0.1 6.6e-17 62.0 0.1 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 CCF40161.1 - 3.8e-06 27.2 0.0 9.7e-06 25.9 0.0 1.7 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Urocanase PF01175.18 CCF40161.1 - 0.029 14.0 0.0 0.41 10.2 0.0 2.1 2 0 0 2 2 2 0 Urocanase Rossmann-like domain NAD_binding_7 PF13241.6 CCF40161.1 - 0.033 14.6 0.1 0.082 13.4 0.1 1.7 2 0 0 2 2 2 0 Putative NAD(P)-binding Semialdhyde_dh PF01118.24 CCF40161.1 - 0.059 13.8 0.1 0.14 12.6 0.0 1.7 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain Epimerase PF01370.21 CCF40161.1 - 0.068 12.6 0.0 0.2 11.1 0.0 1.9 2 1 0 2 2 2 0 NAD dependent epimerase/dehydratase family Kinesin PF00225.23 CCF40162.1 - 3.2e-34 118.4 0.0 3.6e-34 118.2 0.0 1.0 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 CCF40162.1 - 2.8e-22 79.3 0.0 3.9e-22 78.8 0.0 1.2 1 0 0 1 1 1 1 Microtubule binding AdoHcyase_NAD PF00670.21 CCF40162.1 - 0.12 12.4 0.0 0.17 11.9 0.0 1.2 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Pyr_redox_3 PF13738.6 CCF40163.1 - 8e-06 25.3 0.1 1.5e-05 24.4 0.1 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CCF40163.1 - 0.00015 21.0 2.7 0.022 13.9 1.2 2.3 2 0 0 2 2 2 2 FAD binding domain Lycopene_cycl PF05834.12 CCF40163.1 - 0.00051 19.2 0.1 0.0009 18.4 0.1 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 CCF40163.1 - 0.0012 18.2 0.6 0.0037 16.5 0.2 2.0 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CCF40163.1 - 0.0018 17.5 0.9 0.11 11.6 0.0 2.1 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_3 PF01494.19 CCF40163.1 - 0.002 17.5 0.3 0.0044 16.3 0.1 1.6 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.14 CCF40163.1 - 0.0031 16.3 0.6 0.0049 15.6 0.6 1.3 1 0 0 1 1 1 1 HI0933-like protein NAD_binding_8 PF13450.6 CCF40163.1 - 0.015 15.5 0.6 0.04 14.2 0.6 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain AlaDh_PNT_C PF01262.21 CCF40163.1 - 0.068 12.4 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain TrkA_N PF02254.18 CCF40163.1 - 0.12 12.6 0.0 0.26 11.6 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain Pyr_redox PF00070.27 CCF40163.1 - 0.13 12.9 0.0 0.27 11.8 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CCF40163.1 - 0.15 11.1 0.7 0.54 9.3 0.1 2.1 3 0 0 3 3 3 0 Glucose inhibited division protein A LCAT PF02450.15 CCF40164.1 - 2.5e-108 362.7 0.0 3.1e-108 362.4 0.0 1.1 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase Abhydrolase_6 PF12697.7 CCF40164.1 - 0.0029 18.2 0.3 0.0087 16.7 0.1 1.8 1 1 1 2 2 2 1 Alpha/beta hydrolase family DUF1778 PF08681.11 CCF40164.1 - 0.088 12.7 0.0 0.21 11.5 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1778) TFIIB PF00382.19 CCF40167.1 - 8.7e-31 105.8 8.6 4.1e-19 68.4 0.1 2.7 3 0 0 3 3 3 2 Transcription factor TFIIB repeat BRF1 PF07741.13 CCF40167.1 - 2.7e-25 88.6 0.7 2.7e-25 88.6 0.7 3.6 4 0 0 4 4 4 1 Brf1-like TBP-binding domain Cyclin_N PF00134.23 CCF40167.1 - 2.4e-09 37.0 2.1 0.00041 20.1 0.2 2.4 2 0 0 2 2 2 2 Cyclin, N-terminal domain DUF1213 PF06740.12 CCF40167.1 - 0.026 15.1 3.1 0.28 11.8 0.9 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1213) Thioredoxin PF00085.20 CCF40167.1 - 0.11 12.5 0.0 0.24 11.4 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin DUF1349 PF07081.11 CCF40168.1 - 3.4e-26 92.1 0.1 4.1e-26 91.8 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1349) MARVEL PF01284.23 CCF40169.1 - 0.037 14.0 12.2 0.057 13.4 12.2 1.3 1 0 0 1 1 1 0 Membrane-associating domain Peptidase_S24 PF00717.23 CCF40170.1 - 1.9e-07 30.9 0.0 2.9e-07 30.3 0.0 1.3 1 0 0 1 1 1 1 Peptidase S24-like ERO1 PF04137.15 CCF40172.1 - 1.4e-135 452.1 0.0 1.8e-135 451.7 0.0 1.1 1 0 0 1 1 1 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) Alk_phosphatase PF00245.20 CCF40173.1 - 6.4e-75 252.7 0.2 1e-74 252.0 0.2 1.3 1 1 0 1 1 1 1 Alkaline phosphatase Phosphodiest PF01663.22 CCF40173.1 - 1.8e-07 31.1 0.0 2.6e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 CCF40173.1 - 3.1e-07 30.1 0.0 5.3e-07 29.3 0.0 1.5 1 0 0 1 1 1 1 Sulfatase DUF229 PF02995.17 CCF40173.1 - 0.00037 19.2 0.3 0.0007 18.3 0.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF229) DUF1501 PF07394.12 CCF40173.1 - 0.0077 15.3 0.1 0.012 14.7 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1501) Zn_clus PF00172.18 CCF40174.1 - 0.0017 18.5 7.7 0.0043 17.2 7.7 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Orf78 PF06024.12 CCF40175.1 - 0.077 13.3 0.0 0.16 12.3 0.0 1.5 1 0 0 1 1 1 0 Orf78 (ac78) UbiA PF01040.18 CCF40176.1 - 1.7e-30 106.2 15.5 1.7e-30 106.2 15.5 1.5 1 1 0 1 1 1 1 UbiA prenyltransferase family PQ-loop PF04193.14 CCF40176.1 - 0.11 12.2 0.2 0.11 12.2 0.2 2.1 2 0 0 2 2 2 0 PQ loop repeat Zn_clus PF00172.18 CCF40177.1 - 2.6e-06 27.5 10.4 5.3e-06 26.5 10.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Occludin_ELL PF07303.13 CCF40177.1 - 0.11 13.3 0.0 0.2 12.4 0.0 1.4 1 0 0 1 1 1 0 Occludin homology domain LTXXQ PF07813.12 CCF40179.1 - 0.1 13.3 0.1 0.15 12.8 0.1 1.3 1 0 0 1 1 1 0 LTXXQ motif family protein FF PF01846.19 CCF40181.1 - 2.2e-49 165.4 10.0 5.3e-15 55.3 0.2 6.8 6 1 0 6 6 6 5 FF domain WW PF00397.26 CCF40181.1 - 6.7e-19 67.7 18.9 4.7e-11 42.6 4.1 2.8 2 0 0 2 2 2 2 WW domain RhoGAP-FF1 PF16512.5 CCF40181.1 - 0.029 15.0 10.6 1 10.1 0.1 4.3 3 1 1 4 4 4 0 p190-A and -B Rho GAPs FF domain RhoGAP PF00620.27 CCF40181.1 - 0.04 13.7 1.7 0.37 10.6 0.3 2.7 2 0 0 2 2 2 0 RhoGAP domain Lipin_mid PF16876.5 CCF40181.1 - 0.047 13.8 0.6 2.2 8.5 0.5 3.0 1 1 1 2 2 2 0 Lipin/Ned1/Smp2 multi-domain protein middle domain HycH PF07450.11 CCF40181.1 - 0.14 12.5 0.7 0.4 11.1 0.1 2.1 2 0 0 2 2 2 0 Formate hydrogenlyase maturation protein HycH Glyco_hyd_101C PF17451.2 CCF40181.1 - 0.47 10.8 7.8 9.6 6.5 2.4 2.8 1 1 1 2 2 2 0 Glycosyl hydrolase 101 beta sandwich domain DUF4051 PF13260.6 CCF40181.1 - 1.2 8.9 6.1 2.6 7.9 0.3 3.9 3 0 0 3 3 3 0 Protein of unknown function (DUF4051) Glycophorin_A PF01102.18 CCF40183.1 - 0.0055 16.9 1.2 0.02 15.1 0.0 2.3 1 1 1 2 2 2 1 Glycophorin A DUF4448 PF14610.6 CCF40183.1 - 0.011 15.5 0.0 0.027 14.2 0.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF4448) SKG6 PF08693.10 CCF40183.1 - 0.02 14.3 1.5 0.02 14.3 1.5 2.4 3 0 0 3 3 3 0 Transmembrane alpha-helix domain DGF-1_5 PF11038.8 CCF40183.1 - 0.19 11.1 3.2 0.44 9.8 3.2 1.6 1 1 0 1 1 1 0 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 Syndecan PF01034.20 CCF40183.1 - 0.39 10.7 1.3 0.65 10.0 1.3 1.3 1 0 0 1 1 1 0 Syndecan domain PALP PF00291.25 CCF40185.1 - 7e-64 216.1 3.3 7.9e-64 215.9 3.3 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CoA_transf_3 PF02515.17 CCF40186.1 - 4.4e-36 124.8 0.0 1.9e-33 116.1 0.0 2.1 2 0 0 2 2 2 2 CoA-transferase family III Peptidase_M20 PF01546.28 CCF40187.1 - 4e-07 29.9 0.0 4.9e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Tsp45I PF06300.12 CCF40187.1 - 0.052 13.1 0.0 0.083 12.4 0.0 1.2 1 0 0 1 1 1 0 Tsp45I type II restriction enzyme ADH_zinc_N PF00107.26 CCF40188.1 - 6.1e-13 48.9 0.0 1.5e-12 47.6 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCF40188.1 - 0.0022 17.8 0.0 0.0044 16.9 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_N_2 PF16884.5 CCF40188.1 - 0.03 14.2 0.0 0.19 11.6 0.0 2.1 2 0 0 2 2 2 0 N-terminal domain of oxidoreductase KR PF08659.10 CCF40190.1 - 4e-59 199.5 0.3 8.1e-59 198.5 0.3 1.5 1 0 0 1 1 1 1 KR domain ADH_zinc_N_2 PF13602.6 CCF40190.1 - 1.9e-16 61.4 0.0 4.3e-16 60.2 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 CCF40190.1 - 5.4e-16 58.8 0.4 1.9e-15 57.0 0.0 2.2 3 0 0 3 3 3 1 Zinc-binding dehydrogenase adh_short PF00106.25 CCF40190.1 - 8.5e-08 31.9 0.2 2.6e-06 27.0 0.0 2.4 2 0 0 2 2 2 1 short chain dehydrogenase PP-binding PF00550.25 CCF40190.1 - 1.3e-06 28.6 0.1 3.6e-06 27.2 0.0 1.8 2 0 0 2 2 2 1 Phosphopantetheine attachment site adh_short_C2 PF13561.6 CCF40190.1 - 0.00022 20.8 0.1 0.00078 19.1 0.0 1.8 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase ADH_N PF08240.12 CCF40190.1 - 0.022 14.6 0.7 0.071 13.0 0.1 2.0 2 0 0 2 2 2 0 Alcohol dehydrogenase GroES-like domain Prot_ATP_ID_OB PF16450.5 CCF40190.1 - 0.033 14.1 0.1 1.1 9.3 0.0 2.7 2 0 0 2 2 2 0 Proteasomal ATPase OB C-terminal domain Chorismate_bind PF00425.18 CCF40191.1 - 9.7e-68 228.5 0.0 3e-67 226.9 0.0 1.9 1 1 0 1 1 1 1 chorismate binding enzyme GATase PF00117.28 CCF40191.1 - 5.3e-24 85.0 0.0 2.8e-23 82.7 0.0 2.0 1 1 0 1 1 1 1 Glutamine amidotransferase class-I Anth_synt_I_N PF04715.13 CCF40191.1 - 4.8e-14 52.8 0.0 2.2e-13 50.7 0.0 2.0 2 0 0 2 2 2 1 Anthranilate synthase component I, N terminal region Peptidase_C26 PF07722.13 CCF40191.1 - 7.4e-05 22.6 0.1 0.00025 20.9 0.1 1.8 1 1 0 1 1 1 1 Peptidase C26 TrkH PF02386.16 CCF40193.1 - 5.8e-87 292.2 0.8 7.2e-87 291.9 0.8 1.0 1 0 0 1 1 1 1 Cation transport protein DUF5345 PF17280.2 CCF40193.1 - 0.0087 16.0 0.1 0.0087 16.0 0.1 2.0 2 0 0 2 2 2 1 Family of unknown function (DUF5345) zf-C2H2_jaz PF12171.8 CCF40195.1 - 0.043 14.1 0.1 0.14 12.5 0.0 2.0 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.6 CCF40195.1 - 0.17 12.4 4.3 0.21 12.1 2.5 2.2 2 0 0 2 2 2 0 Zinc-finger double domain zf-C2H2 PF00096.26 CCF40195.1 - 0.27 11.8 2.1 1.3 9.6 0.1 2.7 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf_UBZ PF18439.1 CCF40195.1 - 0.44 10.2 8.1 1 9.0 0.0 3.0 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger zf-C2H2_4 PF13894.6 CCF40195.1 - 0.48 11.4 6.7 0.59 11.1 0.2 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger zf-Di19 PF05605.12 CCF40195.1 - 0.76 10.1 0.1 0.76 10.1 0.1 3.1 3 1 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding CMD PF02627.20 CCF40197.1 - 1.7e-18 66.4 0.2 3.7e-18 65.4 0.1 1.6 2 0 0 2 2 2 1 Carboxymuconolactone decarboxylase family TraC PF07820.12 CCF40197.1 - 0.073 13.4 1.1 0.76 10.2 0.1 2.4 3 0 0 3 3 3 0 TraC-like protein Acetyltransf_10 PF13673.7 CCF40198.1 - 6.5e-11 42.3 0.0 8.6e-11 41.9 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CCF40198.1 - 9e-10 38.8 0.0 1.2e-09 38.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CCF40198.1 - 7e-06 26.4 0.0 9.8e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 CCF40198.1 - 8.2e-06 25.9 0.1 0.0002 21.5 0.1 2.1 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 CCF40198.1 - 6.5e-05 23.1 0.0 8.4e-05 22.7 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_6 PF13480.7 CCF40198.1 - 0.00011 22.4 0.7 0.00015 21.9 0.7 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain PanZ PF12568.8 CCF40198.1 - 0.012 15.3 0.1 0.014 15.1 0.1 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain, PanZ NTP_transf_3 PF12804.7 CCF40198.1 - 0.078 13.3 0.2 1 9.7 0.2 2.0 1 1 0 1 1 1 0 MobA-like NTP transferase domain WcbI PF18588.1 CCF40198.1 - 0.081 12.5 0.1 0.17 11.5 0.0 1.5 2 0 0 2 2 2 0 Polysaccharide biosynthesis enzyme WcbI Tyrosinase PF00264.20 CCF40199.1 - 6.1e-53 180.4 0.7 8e-53 180.0 0.7 1.1 1 0 0 1 1 1 1 Common central domain of tyrosinase ECH_1 PF00378.20 CCF40201.1 - 1.6e-15 57.1 0.0 3e-15 56.2 0.0 1.4 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Formyl_trans_C PF02911.18 CCF40201.1 - 1.4e-08 34.9 0.0 2.6e-08 34.0 0.0 1.4 1 0 0 1 1 1 1 Formyl transferase, C-terminal domain Formyl_trans_N PF00551.19 CCF40201.1 - 0.046 13.5 0.0 0.24 11.1 0.0 2.0 1 1 0 1 1 1 0 Formyl transferase RIG-I_C PF18119.1 CCF40201.1 - 0.19 11.8 0.1 1.6 8.7 0.0 2.1 2 0 0 2 2 2 0 RIG-I receptor C-terminal domain DUF2710 PF10921.8 CCF40202.1 - 0.017 15.5 0.0 0.29 11.6 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2710) DMPK_coil PF08826.10 CCF40202.1 - 0.019 15.1 1.0 0.042 14.0 0.1 2.1 2 0 0 2 2 2 0 DMPK coiled coil domain like MAD PF05557.13 CCF40202.1 - 0.033 12.6 1.1 0.051 12.0 1.1 1.2 1 0 0 1 1 1 0 Mitotic checkpoint protein Rx_N PF18052.1 CCF40202.1 - 0.19 12.1 2.4 0.48 10.7 0.3 2.3 2 1 0 2 2 2 0 Rx N-terminal domain DUF3759 PF12585.8 CCF40203.1 - 3.6e-40 135.9 5.7 4.9e-40 135.5 5.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3759) DUF3824 PF12868.7 CCF40203.1 - 0.2 12.3 3.7 1.2 9.8 3.7 2.0 1 1 0 1 1 1 0 Domain of unknwon function (DUF3824) CortBP2 PF09727.9 CCF40206.1 - 0.0018 18.3 1.0 0.0022 17.9 1.0 1.2 1 0 0 1 1 1 1 Cortactin-binding protein-2 MscS_porin PF12795.7 CCF40206.1 - 0.27 10.7 11.8 0.63 9.5 11.8 1.5 1 1 0 1 1 1 0 Mechanosensitive ion channel porin domain NARP1 PF12569.8 CCF40208.1 - 0.068 12.1 2.5 1.3 7.8 1.5 2.2 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 Med3 PF11593.8 CCF40208.1 - 0.096 11.9 1.4 0.14 11.3 1.4 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DUF1387 PF07139.11 CCF40208.1 - 1.2 8.8 7.9 0.76 9.5 5.9 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1387) DUF4142 PF13628.6 CCF40209.1 - 0.062 13.5 0.8 0.17 12.1 0.8 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4142) CMAS PF02353.20 CCF40211.1 - 2e-13 50.2 0.0 2.8e-13 49.8 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_25 PF13649.6 CCF40211.1 - 9.3e-11 42.3 0.1 1.7e-09 38.2 0.0 2.6 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF40211.1 - 1.1e-09 38.3 0.0 2.4e-09 37.2 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF40211.1 - 4.4e-07 30.5 0.0 2.6e-06 28.0 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF40211.1 - 3.1e-06 27.0 0.0 4.5e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF40211.1 - 0.00025 21.7 0.0 0.0016 19.1 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_32 PF13679.6 CCF40211.1 - 0.0045 17.0 0.0 0.0086 16.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 CCF40211.1 - 0.006 16.4 0.0 0.0093 15.7 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MetW PF07021.12 CCF40211.1 - 0.015 14.9 0.0 0.036 13.7 0.0 1.6 2 0 0 2 2 2 0 Methionine biosynthesis protein MetW DOT1 PF08123.13 CCF40211.1 - 0.036 13.6 0.0 0.062 12.8 0.0 1.3 1 0 0 1 1 1 0 Histone methylation protein DOT1 RrnaAD PF00398.20 CCF40211.1 - 0.19 10.7 0.0 0.27 10.2 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Lactamase_B PF00753.27 CCF40212.1 - 1.2e-07 32.0 1.9 3e-07 30.7 1.9 1.6 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CCF40212.1 - 4e-07 29.8 0.2 6e-07 29.2 0.2 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Mod_r PF07200.13 CCF40214.1 - 0.0033 17.5 9.0 0.0063 16.6 9.0 1.3 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein HOOK PF05622.12 CCF40214.1 - 0.0087 14.3 6.5 0.014 13.6 6.5 1.3 1 0 0 1 1 1 1 HOOK protein DUF4404 PF14357.6 CCF40214.1 - 0.022 15.4 3.1 0.022 15.4 3.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) CENP-F_leu_zip PF10473.9 CCF40214.1 - 0.08 13.0 13.7 0.32 11.0 2.9 2.3 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 FapA PF03961.13 CCF40214.1 - 0.3 9.7 2.6 0.4 9.2 2.6 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Pinin_SDK_memA PF04696.13 CCF40214.1 - 0.3 11.1 11.4 0.6 10.2 11.4 1.4 1 0 0 1 1 1 0 pinin/SDK/memA/ protein conserved region ATG16 PF08614.11 CCF40214.1 - 0.89 9.7 15.4 0.051 13.8 8.7 2.1 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) Atg14 PF10186.9 CCF40214.1 - 0.97 8.4 7.2 1.9 7.5 7.2 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DASH_Spc19 PF08287.11 CCF40214.1 - 1 9.2 12.4 1 9.3 7.7 2.3 1 1 1 2 2 2 0 Spc19 APG6_N PF17675.1 CCF40214.1 - 1.8 9.1 11.2 3.4 8.2 11.2 1.4 1 0 0 1 1 1 0 Apg6 coiled-coil region UbiA PF01040.18 CCF40215.1 - 5.4e-24 84.9 11.0 6.7e-24 84.6 11.0 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family CBP PF12192.8 CCF40216.1 - 0.0001 22.4 0.7 0.00017 21.7 0.7 1.3 1 0 0 1 1 1 1 Fungal calcium binding protein adh_short PF00106.25 CCF40219.1 - 5.4e-38 130.4 0.0 8e-38 129.9 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF40219.1 - 1.4e-20 73.8 0.0 2.2e-20 73.2 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF40219.1 - 5.6e-08 32.9 0.1 3.4e-07 30.4 0.1 2.0 1 1 0 1 1 1 1 KR domain 3Beta_HSD PF01073.19 CCF40219.1 - 4.4e-05 22.6 0.0 6.1e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 CCF40219.1 - 0.00052 19.6 0.0 0.00083 18.9 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1776 PF08643.10 CCF40219.1 - 0.0045 16.4 0.0 0.0072 15.7 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Polysacc_synt_2 PF02719.15 CCF40219.1 - 0.21 10.7 0.1 0.33 10.0 0.1 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein G6PD_C PF02781.16 CCF40221.1 - 1.6e-101 339.3 0.0 2.7e-101 338.6 0.0 1.4 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 CCF40221.1 - 6.1e-60 202.9 0.0 1.3e-59 201.8 0.0 1.6 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain Solute_trans_a PF03619.16 CCF40223.1 - 2.4e-100 335.5 10.2 2.9e-100 335.2 10.2 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha Glyco_hydro_92 PF07971.12 CCF40224.1 - 1.8e-57 195.3 0.0 2.2e-57 195.0 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 HSP70 PF00012.20 CCF40225.1 - 4.1e-39 134.3 0.2 2.3e-32 112.0 0.1 2.0 2 0 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 CCF40225.1 - 0.00051 19.0 0.1 0.00068 18.6 0.1 1.1 1 0 0 1 1 1 1 MreB/Mbl protein DUF503 PF04456.12 CCF40225.1 - 0.04 13.8 0.4 24 4.9 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF503) Methyltransf_4 PF02390.17 CCF40227.1 - 1.2e-54 184.3 0.0 1.8e-54 183.8 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_25 PF13649.6 CCF40227.1 - 4e-05 24.2 0.0 0.00014 22.5 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_32 PF13679.6 CCF40227.1 - 0.0019 18.2 0.0 0.0033 17.4 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF40227.1 - 0.003 18.3 0.0 0.014 16.1 0.0 2.1 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF40227.1 - 0.0075 16.9 0.0 0.042 14.5 0.0 2.3 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF40227.1 - 0.0094 15.8 0.0 0.014 15.2 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CCF40227.1 - 0.012 15.2 0.0 0.029 13.9 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase small domain PCMT PF01135.19 CCF40227.1 - 0.019 14.7 0.1 0.073 12.8 0.1 1.9 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.20 CCF40227.1 - 0.079 12.2 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Amidase02_C PF12123.8 CCF40227.1 - 0.14 11.9 0.0 0.34 10.6 0.0 1.6 1 0 0 1 1 1 0 N-acetylmuramoyl-l-alanine amidase PXA PF02194.15 CCF40228.1 - 2.9e-36 125.1 0.2 3.6e-36 124.8 0.2 1.1 1 0 0 1 1 1 1 PXA domain DUF5601 PF18151.1 CCF40228.1 - 0.063 13.6 0.0 0.12 12.7 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5601) Phage_holin_3_6 PF07332.11 CCF40228.1 - 0.073 13.1 4.4 0.13 12.3 4.4 1.3 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III Npa1 PF11707.8 CCF40229.1 - 1.2e-98 330.6 0.0 2.6e-98 329.5 0.0 1.6 1 0 0 1 1 1 1 Ribosome 60S biogenesis N-terminal NopRA1 PF16201.5 CCF40229.1 - 3e-61 206.5 4.2 2.5e-59 200.3 0.1 4.3 4 0 0 4 4 4 1 Nucleolar pre-ribosomal-associated protein 1 FHA PF00498.26 CCF40230.1 - 2.3e-06 27.9 0.0 4e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 CCF40230.1 - 0.0071 16.6 0.0 0.012 15.9 0.0 1.3 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Glyco_hydro_18 PF00704.28 CCF40231.1 - 5.6e-17 62.4 0.1 2e-16 60.6 0.1 1.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 GHL6 PF14871.6 CCF40231.1 - 0.12 12.5 0.0 0.23 11.6 0.0 1.3 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase 6 zf-ANAPC11 PF12861.7 CCF40233.1 - 6.1e-45 151.2 11.6 7e-45 151.0 11.6 1.0 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 CCF40233.1 - 7.8e-22 77.3 11.9 1.1e-21 76.8 11.9 1.2 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 CCF40233.1 - 1.3e-07 31.8 15.3 3.1e-06 27.4 15.3 2.5 1 1 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 CCF40233.1 - 3.8e-05 23.6 9.0 0.00027 20.9 5.2 2.5 2 1 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 CCF40233.1 - 0.00013 21.7 13.6 0.00056 19.7 13.6 2.1 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CCF40233.1 - 0.00053 19.8 7.1 0.00053 19.8 7.1 2.2 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 CCF40233.1 - 0.0025 17.6 3.2 0.0025 17.6 3.2 2.4 1 1 1 2 2 2 1 RING/Ubox like zinc-binding domain FANCL_C PF11793.8 CCF40233.1 - 0.0046 17.1 16.8 0.12 12.6 16.8 3.1 1 1 0 1 1 1 1 FANCL C-terminal domain zf-C3HC4_2 PF13923.6 CCF40233.1 - 0.0057 16.5 13.2 0.0057 16.5 13.2 2.5 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 CCF40233.1 - 0.0062 16.1 12.3 0.054 13.1 12.3 2.2 1 1 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-C3HC4_4 PF15227.6 CCF40233.1 - 0.0082 16.3 11.3 0.0092 16.1 8.7 2.3 1 1 1 2 2 2 1 zinc finger of C3HC4-type, RING zf-Nse PF11789.8 CCF40233.1 - 0.011 15.6 4.4 0.018 14.8 4.4 1.5 1 1 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-HIT PF04438.16 CCF40233.1 - 0.022 14.6 3.4 0.08 12.8 1.0 2.4 2 0 0 2 2 2 0 HIT zinc finger YacG PF03884.14 CCF40233.1 - 0.086 12.6 7.3 0.092 12.5 0.4 2.6 2 0 0 2 2 2 0 DNA gyrase inhibitor YacG Rad50_zn_hook PF04423.14 CCF40233.1 - 0.12 12.3 3.8 0.29 11.0 0.0 2.5 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-RING_5 PF14634.6 CCF40233.1 - 0.16 12.0 17.5 5.7 7.0 17.8 2.8 1 1 1 2 2 2 0 zinc-RING finger domain zf-RING_11 PF17123.5 CCF40233.1 - 0.2 11.4 12.7 0.68 9.7 9.6 2.8 2 1 0 2 2 2 0 RING-like zinc finger DUF2256 PF10013.9 CCF40233.1 - 0.37 10.9 0.3 0.37 10.9 0.3 3.4 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2256) UBZ_FAAP20 PF15750.5 CCF40233.1 - 0.69 9.9 6.8 2 8.5 0.3 2.8 2 1 1 3 3 3 0 Ubiquitin-binding zinc-finger Opy2 PF09463.10 CCF40233.1 - 3.1 8.2 10.7 5.7 7.4 6.2 2.4 2 1 0 2 2 2 0 Opy2 protein zf-RING-like PF08746.11 CCF40233.1 - 3.4 8.0 13.2 26 5.2 13.2 2.2 1 1 0 1 1 1 0 RING-like domain RINGv PF12906.7 CCF40233.1 - 3.4 7.9 13.3 6.2 7.0 11.9 2.3 1 1 1 2 2 2 0 RING-variant domain DZR PF12773.7 CCF40233.1 - 3.7 7.6 13.0 4.1 7.5 5.9 2.2 1 1 1 2 2 2 0 Double zinc ribbon zf-C2H2_9 PF16293.5 CCF40233.1 - 4 7.4 7.5 7.2 6.5 0.1 3.2 3 1 0 3 3 2 0 C2H2 type zinc-finger (1 copy) ACTH_assoc PF16102.5 CCF40234.1 - 0.00084 19.9 7.1 0.24 12.2 0.1 3.9 3 0 0 3 3 3 2 ACTH-associated domain adh_short PF00106.25 CCF40235.1 - 1.5e-28 99.6 0.7 1.2e-17 64.1 0.2 3.2 2 1 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCF40235.1 - 6.6e-23 81.5 0.6 8.8e-13 48.3 0.0 3.1 3 0 0 3 3 3 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF40235.1 - 3.4e-06 27.1 0.1 1.1e-05 25.4 0.0 1.9 2 1 0 2 2 2 1 KR domain Pectate_lyase PF03211.13 CCF40236.1 - 1.4e-63 214.2 1.2 1.8e-63 213.8 1.2 1.1 1 0 0 1 1 1 1 Pectate lyase Glyco_hydro_16 PF00722.21 CCF40237.1 - 3.7e-11 42.8 1.5 4.8e-11 42.4 1.5 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 AMP-binding PF00501.28 CCF40238.1 - 1.1e-78 264.8 0.0 1.3e-78 264.5 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CCF40238.1 - 1.4e-15 58.0 0.2 2.9e-15 57.0 0.2 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Striatin PF08232.12 CCF40239.1 - 6.7e-42 143.7 6.7 6.7e-42 143.7 6.7 2.6 2 1 0 2 2 1 1 Striatin family WD40 PF00400.32 CCF40239.1 - 8.5e-27 92.9 17.6 2.8e-05 24.8 0.0 7.9 7 1 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF40239.1 - 1e-05 25.7 0.0 4.7 7.6 0.0 4.7 3 1 2 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain ADH_N_2 PF16884.5 CCF40239.1 - 0.034 14.0 0.1 0.19 11.6 0.0 2.1 2 0 0 2 2 2 0 N-terminal domain of oxidoreductase Ge1_WD40 PF16529.5 CCF40239.1 - 0.12 11.3 0.0 0.86 8.5 0.0 2.3 2 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 CCF40239.1 - 0.15 10.6 0.0 0.31 9.5 0.0 1.4 1 0 0 1 1 1 0 Cytochrome D1 heme domain Spt20 PF12090.8 CCF40239.1 - 0.45 10.1 40.8 1.3 8.6 40.8 1.7 1 0 0 1 1 1 0 Spt20 family GREB1 PF15782.5 CCF40239.1 - 1 6.4 10.8 1.3 6.1 10.8 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer EPL1 PF10513.9 CCF40239.1 - 4.2 7.7 14.8 0.19 12.1 8.1 2.1 2 0 0 2 2 2 0 Enhancer of polycomb-like RNA_pol_Rbc25 PF08292.12 CCF40239.1 - 4.6 7.5 8.5 14 5.9 8.5 1.8 1 0 0 1 1 1 0 RNA polymerase III subunit Rpc25 Zip PF02535.22 CCF40239.1 - 5.4 6.1 5.8 11 5.2 5.8 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter SAT PF16073.5 CCF40242.1 - 3.5e-69 233.2 0.6 5.5e-69 232.6 0.6 1.3 1 0 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis ketoacyl-synt PF00109.26 CCF40242.1 - 1.2e-28 100.4 0.0 3.3e-28 99.0 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain DUF3877 PF12993.7 CCF40243.1 - 0.1 12.4 0.1 0.12 12.2 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function, E. rectale Gene description (DUF3877) Bcr-Abl_Oligo PF09036.10 CCF40244.1 - 0.029 14.4 0.9 0.029 14.4 0.9 2.5 3 0 0 3 3 3 0 Bcr-Abl oncoprotein oligomerisation domain Pox_A_type_inc PF04508.12 CCF40244.1 - 0.035 14.0 3.6 0.035 14.0 3.6 4.1 4 0 0 4 4 4 0 Viral A-type inclusion protein repeat DUF4201 PF13870.6 CCF40244.1 - 0.04 13.6 0.0 0.04 13.6 0.0 3.5 1 1 2 3 3 3 0 Domain of unknown function (DUF4201) LPD23 PF18838.1 CCF40244.1 - 0.057 13.2 0.1 0.11 12.3 0.1 1.5 1 0 0 1 1 1 0 Large polyvalent protein associated domain 23 V_ATPase_I PF01496.19 CCF40244.1 - 0.67 7.8 9.6 37 2.0 9.6 2.0 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family DASH_Spc34 PF08657.10 CCF40244.1 - 0.88 9.3 6.5 1.2 8.9 5.8 1.4 1 1 0 1 1 1 0 DASH complex subunit Spc34 TSC22 PF01166.18 CCF40244.1 - 2.7 8.4 6.1 14 6.1 0.8 3.2 3 1 0 3 3 3 0 TSC-22/dip/bun family ABC_tran_CTD PF16326.5 CCF40244.1 - 3.5 7.9 8.2 9.3 6.6 0.5 2.7 2 0 0 2 2 2 0 ABC transporter C-terminal domain ADIP PF11559.8 CCF40244.1 - 5.2 7.1 14.6 5.2 7.1 6.3 2.5 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding adh_short PF00106.25 CCF40246.1 - 1.6e-23 83.2 0.0 2.4e-23 82.6 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF40246.1 - 1.6e-13 50.8 0.0 2.1e-13 50.4 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF40246.1 - 0.072 13.0 0.0 0.3 11.0 0.1 1.9 2 0 0 2 2 2 0 KR domain HhH-GPD PF00730.25 CCF40248.1 - 1.2e-10 41.8 0.0 2.1e-10 41.0 0.0 1.5 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein DUF3445 PF11927.8 CCF40248.1 - 0.14 11.8 0.0 0.2 11.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3445) Ndc1_Nup PF09531.10 CCF40248.1 - 1.2 7.7 3.6 1.4 7.5 3.6 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Pkinase PF00069.25 CCF40250.1 - 3.6e-51 174.1 0.0 4.6e-51 173.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF40250.1 - 1.1e-23 83.8 0.0 3e-23 82.4 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.11 CCF40250.1 - 0.025 13.5 0.1 0.04 12.9 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase RIO1 PF01163.22 CCF40250.1 - 0.063 12.9 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 RIO1 family APH PF01636.23 CCF40250.1 - 0.3 11.0 2.0 0.43 10.5 0.1 2.0 2 1 1 3 3 3 0 Phosphotransferase enzyme family HET PF06985.11 CCF40252.1 - 2.7e-12 47.3 3.8 3.7e-09 37.1 0.1 2.1 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) Transp_cyt_pur PF02133.15 CCF40253.1 - 3.4e-153 510.6 31.8 3.9e-153 510.4 31.8 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Pkinase PF00069.25 CCF40254.1 - 2.1e-51 174.8 0.0 5.2e-51 173.5 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF40254.1 - 8.9e-20 71.1 0.0 4e-19 68.9 0.0 2.0 2 1 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF40254.1 - 0.023 14.0 0.3 6.7 5.9 0.1 2.4 2 0 0 2 2 2 0 Kinase-like PRA1 PF03208.19 CCF40255.1 - 1.3e-08 34.5 2.9 2.4e-08 33.7 2.9 1.3 1 0 0 1 1 1 1 PRA1 family protein FA_desaturase PF00487.24 CCF40255.1 - 0.41 10.4 4.0 0.71 9.7 4.0 1.4 1 0 0 1 1 1 0 Fatty acid desaturase Ribosomal_60s PF00428.19 CCF40255.1 - 1.6 9.4 4.9 5 7.8 4.9 1.8 1 0 0 1 1 1 0 60s Acidic ribosomal protein Rrn6 PF10214.9 CCF40255.1 - 3.1 6.2 14.3 4.4 5.7 14.3 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor CTP_transf_like PF01467.26 CCF40256.1 - 0.015 15.5 0.0 0.095 12.9 0.0 2.3 2 1 0 2 2 2 0 Cytidylyltransferase-like Glycos_transf_1 PF00534.20 CCF40257.1 - 2.2e-36 125.0 0.0 1.1e-34 119.4 0.0 2.2 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 CCF40257.1 - 1.3e-16 61.1 0.1 2.2e-16 60.3 0.1 1.3 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.6 CCF40257.1 - 1.5e-15 57.8 0.0 5.2e-15 56.1 0.0 1.9 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 CCF40257.1 - 9.9e-08 32.6 0.7 2.1e-07 31.5 0.2 1.7 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain ALG11_N PF15924.5 CCF40257.1 - 0.0036 17.4 0.6 0.14 12.2 0.1 2.8 1 1 1 2 2 2 1 ALG11 mannosyltransferase N-terminus Glyco_trans_1_2 PF13524.6 CCF40257.1 - 0.0063 16.9 0.0 0.013 15.8 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 ECH_1 PF00378.20 CCF40258.1 - 3.3e-17 62.7 0.0 4.1e-17 62.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CCF40258.1 - 4.3e-08 33.0 0.0 5.5e-08 32.7 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Peptidase_S49 PF01343.18 CCF40258.1 - 0.002 18.1 0.0 1.2 9.1 0.0 2.5 3 0 0 3 3 3 2 Peptidase family S49 RabGAP-TBC PF00566.18 CCF40259.1 - 2e-49 168.1 0.0 3e-49 167.6 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain zf-C2H2 PF00096.26 CCF40260.1 - 0.00063 20.1 3.7 0.13 12.8 0.4 2.5 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCF40260.1 - 0.0043 17.8 2.0 3.4 8.8 0.2 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-ribbon_3 PF13248.6 CCF40260.1 - 0.035 13.5 0.1 0.077 12.4 0.1 1.6 1 0 0 1 1 1 0 zinc-ribbon domain Zn-ribbon_8 PF09723.10 CCF40260.1 - 0.044 13.9 0.2 0.1 12.7 0.2 1.7 1 0 0 1 1 1 0 Zinc ribbon domain zf-H2C2_2 PF13465.6 CCF40260.1 - 0.091 13.2 1.0 0.14 12.7 0.0 1.8 2 0 0 2 2 2 0 Zinc-finger double domain Glyco_hydro_43 PF04616.14 CCF40261.1 - 4.7e-38 131.1 1.3 5.7e-38 130.9 1.3 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 LRR_10 PF18805.1 CCF40261.1 - 0.025 14.2 0.2 0.1 12.3 0.2 2.0 2 0 0 2 2 2 0 Leucine-rich repeat Pantoate_ligase PF02569.15 CCF40263.1 - 4.4e-86 288.4 0.0 5e-86 288.2 0.0 1.0 1 0 0 1 1 1 1 Pantoate-beta-alanine ligase Acyltransferase PF01553.21 CCF40264.1 - 2.9e-16 59.3 0.0 5.4e-16 58.4 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase RAP PF08373.10 CCF40264.1 - 0.058 13.5 0.0 0.15 12.2 0.0 1.6 1 0 0 1 1 1 0 RAP domain SGL PF08450.12 CCF40265.1 - 1.3e-13 51.1 0.0 5.2e-13 49.2 0.0 1.8 1 1 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region NHL PF01436.21 CCF40265.1 - 0.12 12.4 0.0 11 6.3 0.0 3.5 3 0 0 3 3 3 0 NHL repeat HET PF06985.11 CCF40266.1 - 0.038 14.3 0.5 0.077 13.4 0.0 1.8 2 0 0 2 2 2 0 Heterokaryon incompatibility protein (HET) COesterase PF00135.28 CCF40267.1 - 3.3e-66 224.2 0.0 4.6e-66 223.7 0.0 1.2 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CCF40267.1 - 1.5e-06 28.3 0.4 0.00018 21.4 0.0 2.9 3 0 0 3 3 3 2 alpha/beta hydrolase fold MR_MLE_C PF13378.6 CCF40268.1 - 2.5e-57 194.0 0.0 3.8e-57 193.4 0.0 1.2 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 CCF40268.1 - 0.017 14.3 0.0 0.028 13.6 0.0 1.3 1 0 0 1 1 1 0 Methylaspartate ammonia-lyase C-terminus MR_MLE_N PF02746.16 CCF40268.1 - 0.042 14.1 0.0 0.12 12.6 0.0 1.7 2 0 0 2 2 2 0 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain Methyltransf_16 PF10294.9 CCF40269.1 - 2.7e-10 40.2 0.0 3.8e-10 39.8 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase PrmA PF06325.13 CCF40269.1 - 0.0053 16.2 0.0 0.0091 15.4 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Vps39_2 PF10367.9 CCF40270.1 - 4.6e-09 36.7 0.0 6e-09 36.3 0.0 1.1 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 CorC_HlyC PF03471.17 CCF40270.1 - 0.015 15.3 0.1 0.029 14.4 0.0 1.4 1 1 0 1 1 1 0 Transporter associated domain Cation_ATPase_C PF00689.21 CCF40272.1 - 4.9e-47 160.0 5.8 9.7e-47 159.0 5.8 1.5 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 CCF40272.1 - 4.1e-33 114.4 0.2 4.1e-33 114.4 0.2 2.3 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase PF13246.6 CCF40272.1 - 3e-21 75.3 0.0 8.2e-21 73.9 0.0 1.8 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 CCF40272.1 - 3.5e-18 66.7 0.8 2.1e-15 57.6 0.0 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 CCF40272.1 - 0.0012 18.6 0.4 0.0023 17.7 0.4 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Herpes_capsid PF06112.11 CCF40274.1 - 0.29 11.2 6.4 0.31 11.1 6.4 1.1 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein UDG PF03167.19 CCF40275.1 - 1.4e-23 83.6 0.1 3.2e-23 82.4 0.1 1.5 2 0 0 2 2 2 1 Uracil DNA glycosylase superfamily GSH_synth_ATP PF03917.17 CCF40275.1 - 0.13 11.0 0.0 0.16 10.7 0.0 1.2 1 0 0 1 1 1 0 Eukaryotic glutathione synthase, ATP binding domain DUF1708 PF08101.11 CCF40277.1 - 1.4e-182 607.7 0.0 1.9e-182 607.2 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1708) Sel1 PF08238.12 CCF40278.1 - 2.6e-24 85.1 18.9 0.00033 21.2 0.2 8.0 8 0 0 8 8 8 6 Sel1 repeat TPR_7 PF13176.6 CCF40278.1 - 0.031 14.3 1.1 0.84 9.8 0.1 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat OPA3 PF07047.12 CCF40278.1 - 0.036 13.8 0.1 0.067 13.0 0.1 1.4 1 0 0 1 1 1 0 Optic atrophy 3 protein (OPA3) TPR_1 PF00515.28 CCF40278.1 - 0.052 13.4 0.3 1.4 8.8 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 CCF40278.1 - 0.1 12.8 0.2 5.5 7.5 0.0 3.6 3 1 1 4 4 4 0 Tetratricopeptide repeat PspB PF06667.12 CCF40278.1 - 0.13 12.3 0.2 0.54 10.4 0.0 2.0 2 0 0 2 2 2 0 Phage shock protein B O-FucT PF10250.9 CCF40280.1 - 1.4e-09 38.1 0.0 7.4e-09 35.7 0.0 2.0 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase Galactosyl_T PF01762.21 CCF40280.1 - 0.14 12.0 0.0 0.24 11.2 0.0 1.3 1 0 0 1 1 1 0 Galactosyltransferase DUF4478 PF14793.6 CCF40280.1 - 0.16 11.9 0.0 0.31 11.0 0.0 1.4 1 0 0 1 1 1 0 Pyrimidine/purine nucleotide 5'-monophosphate nucleosidases FMO-like PF00743.19 CCF40281.1 - 2.9e-31 108.5 0.0 3.3e-20 72.0 0.0 3.0 3 0 0 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 CCF40281.1 - 3e-11 43.2 0.2 1.7e-06 27.5 0.0 3.2 2 1 1 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CCF40281.1 - 5e-07 29.2 0.0 0.0008 18.7 0.1 3.0 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCF40281.1 - 1.9e-06 28.0 0.0 5.5e-06 26.5 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 CCF40281.1 - 2.2e-05 24.5 0.1 0.00085 19.3 0.1 3.0 2 1 0 2 2 2 1 FAD-NAD(P)-binding DAO PF01266.24 CCF40281.1 - 0.00015 21.5 0.7 0.027 14.1 0.3 2.4 2 0 0 2 2 2 2 FAD dependent oxidoreductase K_oxygenase PF13434.6 CCF40281.1 - 0.00024 20.4 0.2 0.039 13.1 0.0 3.1 2 1 1 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.14 CCF40281.1 - 0.034 12.8 0.4 0.057 12.1 0.4 1.3 1 0 0 1 1 1 0 HI0933-like protein Semialdhyde_dh PF01118.24 CCF40281.1 - 0.063 13.7 0.0 0.38 11.2 0.0 2.2 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain Glu_dehyd_C PF16912.5 CCF40281.1 - 0.072 12.6 0.0 0.15 11.5 0.0 1.5 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus OCD_Mu_crystall PF02423.15 CCF40281.1 - 0.11 11.4 0.2 0.17 10.8 0.2 1.2 1 0 0 1 1 1 0 Ornithine cyclodeaminase/mu-crystallin family Thi4 PF01946.17 CCF40281.1 - 0.18 11.0 0.1 0.32 10.2 0.1 1.2 1 0 0 1 1 1 0 Thi4 family MRP PF09387.10 CCF40282.1 - 0.093 12.7 0.6 0.11 12.5 0.6 1.0 1 0 0 1 1 1 0 Mitochondrial RNA binding protein MRP adh_short PF00106.25 CCF40283.1 - 9.2e-20 70.9 0.0 1.4e-19 70.3 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF40283.1 - 1.2e-15 57.8 0.0 1.7e-15 57.2 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase SNRNP27 PF08648.12 CCF40284.1 - 2.4e-27 94.8 2.4 4.2e-27 94.0 2.4 1.4 1 0 0 1 1 1 1 U4/U6.U5 small nuclear ribonucleoproteins PGAP1 PF07819.13 CCF40286.1 - 1.2e-06 28.5 0.5 6.1e-05 22.8 0.1 2.1 1 1 1 2 2 2 1 PGAP1-like protein DUF676 PF05057.14 CCF40286.1 - 7.8e-06 25.5 0.0 1e-05 25.2 0.0 1.1 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_6 PF12697.7 CCF40286.1 - 2e-05 25.3 0.1 2e-05 25.3 0.1 2.1 1 1 1 2 2 2 1 Alpha/beta hydrolase family UPF0227 PF05728.12 CCF40286.1 - 5e-05 23.3 0.1 6.4e-05 23.0 0.1 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0227) Abhydrolase_3 PF07859.13 CCF40286.1 - 0.0017 18.3 0.0 0.0021 18.0 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Thioesterase PF00975.20 CCF40286.1 - 0.002 18.3 0.1 0.0036 17.5 0.1 1.4 1 1 0 1 1 1 1 Thioesterase domain Lipase_3 PF01764.25 CCF40286.1 - 0.0027 17.6 0.0 0.0034 17.3 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 CCF40286.1 - 0.0035 16.7 0.0 0.0053 16.1 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CCF40286.1 - 0.0039 16.9 0.2 0.013 15.2 0.2 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold DUF915 PF06028.11 CCF40286.1 - 0.013 14.8 0.1 1.8 7.8 0.0 2.1 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) LIDHydrolase PF10230.9 CCF40286.1 - 0.031 13.8 0.1 0.038 13.6 0.1 1.2 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase CHASE2 PF05226.11 CCF40286.1 - 0.083 12.6 0.0 0.091 12.5 0.0 1.1 1 0 0 1 1 1 0 CHASE2 domain LCAT PF02450.15 CCF40286.1 - 0.17 11.0 0.0 0.23 10.6 0.0 1.1 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase DUF900 PF05990.12 CCF40286.1 - 0.22 11.0 0.6 0.86 9.1 0.6 1.8 1 1 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Zip PF02535.22 CCF40288.1 - 1.1e-55 189.2 6.6 2.3e-55 188.1 6.6 1.5 1 1 0 1 1 1 1 ZIP Zinc transporter CTD_bind PF04818.13 CCF40289.1 - 3.4e-12 47.0 0.0 7.1e-12 46.0 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase II-binding domain. B56 PF01603.20 CCF40290.1 - 1e-192 640.7 3.9 1.2e-192 640.5 3.9 1.0 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) Sec7_N PF12783.7 CCF40290.1 - 0.00065 19.6 1.6 0.31 10.9 0.0 2.4 2 0 0 2 2 2 2 Guanine nucleotide exchange factor in Golgi transport N-terminal Tau95 PF09734.9 CCF40291.1 - 2.3e-37 128.9 0.2 4.9e-37 127.9 0.2 1.6 1 0 0 1 1 1 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain Tau95_N PF17682.1 CCF40291.1 - 2.8e-32 111.6 0.0 4.7e-32 110.9 0.0 1.4 1 0 0 1 1 1 1 Tau95 Triple barrel domain BCS1_N PF08740.11 CCF40292.1 - 1.5e-49 168.6 0.1 2.7e-49 167.7 0.1 1.4 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 CCF40292.1 - 2.6e-16 60.2 0.0 1.6e-07 31.8 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 CCF40292.1 - 0.004 16.9 0.0 0.0068 16.2 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_25 PF13481.6 CCF40292.1 - 0.027 14.0 0.0 0.057 13.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 CCF40292.1 - 0.041 13.9 0.0 0.13 12.3 0.0 1.9 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) ATPase PF06745.13 CCF40292.1 - 0.061 12.7 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 KaiC AAA_16 PF13191.6 CCF40292.1 - 0.092 13.1 0.2 0.35 11.2 0.2 2.1 1 1 0 1 1 1 0 AAA ATPase domain AAA_18 PF13238.6 CCF40292.1 - 0.14 12.7 0.1 0.55 10.8 0.1 2.1 1 1 0 1 1 1 0 AAA domain CwsA PF10814.8 CCF40293.1 - 0.077 13.2 0.1 0.13 12.4 0.1 1.3 1 0 0 1 1 1 0 Cell wall synthesis protein CwsA NIBRIN_BRCT_II PF16508.5 CCF40293.1 - 0.082 13.2 0.0 0.17 12.2 0.0 1.5 1 1 1 2 2 2 0 Second BRCT domain on Nijmegen syndrome breakage protein DUF3148 PF11347.8 CCF40293.1 - 0.11 12.3 0.0 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3148) IBN_N PF03810.19 CCF40294.1 - 2.2e-13 49.9 0.1 4.7e-13 48.9 0.1 1.6 1 0 0 1 1 1 1 Importin-beta N-terminal domain Xpo1 PF08389.12 CCF40294.1 - 2.3e-13 50.4 1.8 2.3e-13 50.4 1.8 1.8 2 0 0 2 2 2 1 Exportin 1-like protein Mem_trans PF03547.18 CCF40294.1 - 0.0079 14.6 0.0 0.014 13.8 0.0 1.5 1 1 0 1 1 1 1 Membrane transport protein Aminotran_5 PF00266.19 CCF40295.1 - 9.4e-27 93.9 0.0 1.2e-26 93.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 CCF40295.1 - 0.00012 21.4 0.0 0.00026 20.3 0.0 1.6 1 1 0 1 1 1 1 Aminotransferase class I and II B12-binding PF02310.19 CCF40295.1 - 0.00071 19.6 0.1 0.079 13.0 0.0 2.8 2 1 1 3 3 3 1 B12 binding domain RusA PF05866.11 CCF40295.1 - 0.16 12.5 0.0 0.32 11.5 0.0 1.5 1 0 0 1 1 1 0 Endodeoxyribonuclease RusA tRNA-synt_1b PF00579.25 CCF40297.1 - 4e-19 69.0 0.6 8.3e-19 68.0 0.0 1.8 2 1 0 2 2 2 1 tRNA synthetases class I (W and Y) DUF1682 PF07946.14 CCF40297.1 - 1 8.5 7.3 1.6 7.8 7.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) DUF4295 PF14128.6 CCF40298.1 - 0.064 13.1 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4295) WD40 PF00400.32 CCF40300.1 - 0.0018 19.1 1.9 0.54 11.2 0.0 4.2 5 1 0 5 5 5 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF40300.1 - 0.0026 18.0 0.0 0.64 10.4 0.0 3.7 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Hira PF07569.11 CCF40300.1 - 0.069 12.9 0.0 0.77 9.4 0.0 2.2 2 0 0 2 2 2 0 TUP1-like enhancer of split MFS_1 PF07690.16 CCF40302.1 - 7.4e-14 51.4 6.0 1e-13 51.0 6.0 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF40302.1 - 4.6e-06 25.7 1.5 6.5e-06 25.3 1.5 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter TRI12 PF06609.13 CCF40302.1 - 0.0084 14.6 0.2 0.011 14.2 0.2 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 CCF40303.1 - 4.9e-78 263.0 18.8 5.6e-78 262.8 18.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF40303.1 - 9.4e-29 100.4 25.6 1.4e-28 99.8 25.6 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily AA_permease_C PF13906.6 CCF40303.1 - 0.13 12.4 1.4 0.69 10.0 1.4 2.3 1 0 0 1 1 1 0 C-terminus of AA_permease Phage_holin_3_2 PF04550.12 CCF40303.1 - 0.23 12.1 1.9 0.78 10.3 1.9 1.9 1 0 0 1 1 1 0 Phage holin family 2 Peptidase_S28 PF05577.12 CCF40304.1 - 0.2 10.4 0.0 0.25 10.1 0.0 1.1 1 0 0 1 1 1 0 Serine carboxypeptidase S28 FA_hydroxylase PF04116.13 CCF40306.1 - 3.3e-23 82.5 10.8 3.3e-23 82.5 10.8 2.0 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily DUF829 PF05705.14 CCF40307.1 - 1.1e-43 149.8 0.0 1.7e-43 149.3 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF829) SesA PF17107.5 CCF40308.1 - 0.072 13.3 0.1 0.18 12.0 0.1 1.7 1 1 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Sec2p PF06428.11 CCF40308.1 - 0.076 13.0 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 GDP/GTP exchange factor Sec2p PBP PF01161.20 CCF40312.1 - 8.8e-16 58.4 0.0 1.1e-15 58.1 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein NUDIX_4 PF14815.6 CCF40313.1 - 4.3e-21 74.9 0.0 1.1e-20 73.6 0.0 1.8 1 0 0 1 1 1 1 NUDIX domain HhH-GPD PF00730.25 CCF40313.1 - 1.8e-19 70.1 0.0 4.6e-19 68.9 0.0 1.7 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 CCF40313.1 - 2.1e-07 30.5 0.1 7e-07 28.8 0.1 1.9 1 0 0 1 1 1 1 Helix-hairpin-helix motif FeS PF04060.13 CCF40313.1 - 0.011 15.4 0.9 0.03 14.0 0.9 1.8 1 0 0 1 1 1 0 Putative Fe-S cluster EndIII_4Fe-2S PF10576.9 CCF40313.1 - 0.15 12.5 0.8 0.44 11.0 0.8 1.8 1 0 0 1 1 1 0 Iron-sulfur binding domain of endonuclease III PTPRCAP PF15713.5 CCF40313.1 - 2 8.7 12.1 21 5.4 0.1 3.3 2 1 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated Fungal_trans_2 PF11951.8 CCF40314.1 - 8.3e-10 38.0 0.2 1.3e-09 37.4 0.2 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain YgbA_NO PF11756.8 CCF40314.1 - 0.056 13.8 0.4 0.11 12.8 0.4 1.5 1 0 0 1 1 1 0 Nitrous oxide-stimulated promoter ABC_membrane PF00664.23 CCF40315.1 - 5.4e-75 252.6 40.5 2.1e-46 158.8 11.8 2.4 2 1 1 3 3 3 2 ABC transporter transmembrane region ABC_tran PF00005.27 CCF40315.1 - 1.7e-13 51.2 0.0 1.6e-12 48.1 0.0 2.2 1 1 0 1 1 1 1 ABC transporter SMC_N PF02463.19 CCF40315.1 - 8.8e-06 25.3 0.6 0.064 12.7 0.0 2.3 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CCF40315.1 - 0.00045 19.9 0.2 0.0014 18.4 0.2 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 CCF40315.1 - 0.0029 18.1 0.2 0.005 17.4 0.2 1.3 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CCF40315.1 - 0.0073 16.7 0.1 0.043 14.2 0.1 2.3 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 CCF40315.1 - 0.012 15.8 0.1 0.1 12.9 0.1 2.2 1 1 0 1 1 1 0 AAA domain AAA_30 PF13604.6 CCF40315.1 - 0.039 13.7 0.1 0.26 11.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 CCF40315.1 - 0.049 13.5 0.0 0.095 12.6 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_21 PF13304.6 CCF40315.1 - 0.1 12.4 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_25 PF13481.6 CCF40315.1 - 0.11 12.1 0.1 0.38 10.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain Hydant_A_N PF05378.13 CCF40316.1 - 3e-62 209.5 2.0 2.3e-60 203.4 0.1 2.1 2 0 0 2 2 2 2 Hydantoinase/oxoprolinase N-terminal region Hydantoinase_A PF01968.18 CCF40316.1 - 4.3e-33 114.8 1.1 6.2e-33 114.3 0.1 1.7 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase Nexin_C PF08628.12 CCF40317.1 - 6.4e-24 84.7 0.1 1.5e-23 83.5 0.1 1.7 1 0 0 1 1 1 1 Sorting nexin C terminal PX PF00787.24 CCF40317.1 - 6.9e-06 26.0 0.0 1.3e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 PX domain zf-C2H2 PF00096.26 CCF40320.1 - 3.1e-05 24.2 13.7 0.067 13.7 2.3 3.5 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCF40320.1 - 0.0058 17.4 11.0 2.2 9.3 1.5 3.5 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_aberr PF17017.5 CCF40320.1 - 0.028 14.5 0.1 0.4 10.8 0.0 2.2 2 0 0 2 2 2 0 Aberrant zinc-finger FmiP_Thoc5 PF09766.9 CCF40320.1 - 0.036 13.4 0.9 0.053 12.8 0.9 1.2 1 0 0 1 1 1 0 Fms-interacting protein/Thoc5 Herpes_BLRF2 PF05812.12 CCF40320.1 - 0.084 13.0 0.3 0.18 12.0 0.3 1.5 1 0 0 1 1 1 0 Herpesvirus BLRF2 protein DUF4763 PF15960.5 CCF40320.1 - 0.088 12.1 2.1 0.14 11.4 2.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) APG6_N PF17675.1 CCF40320.1 - 0.11 13.0 1.9 0.17 12.4 1.9 1.2 1 0 0 1 1 1 0 Apg6 coiled-coil region HIP1_clath_bdg PF16515.5 CCF40320.1 - 0.11 13.1 4.4 0.2 12.3 4.2 1.4 1 1 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 GAS PF13851.6 CCF40320.1 - 0.12 11.8 2.2 0.18 11.2 2.2 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding DivIC PF04977.15 CCF40320.1 - 0.13 12.0 0.5 0.24 11.2 0.5 1.4 1 0 0 1 1 1 0 Septum formation initiator FOXP-CC PF16159.5 CCF40320.1 - 0.15 12.7 0.2 0.15 12.7 0.2 3.4 3 1 0 3 3 3 0 FOXP coiled-coil domain HAUS5 PF14817.6 CCF40320.1 - 0.23 10.2 3.0 0.31 9.7 3.0 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 5 UPF0242 PF06785.11 CCF40320.1 - 0.26 11.4 1.4 0.35 10.9 1.4 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Nup188 PF10487.9 CCF40321.1 - 2.1e-16 59.1 0.0 1.2e-12 46.7 0.0 2.2 2 0 0 2 2 2 2 Nucleoporin subcomplex protein binding to Pom34 GATase PF00117.28 CCF40322.1 - 4.6e-46 157.0 0.0 5.6e-46 156.7 0.0 1.1 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 CCF40322.1 - 2.9e-05 24.0 0.3 0.00026 20.8 0.3 2.0 1 1 0 1 1 1 1 Peptidase C26 Sugar_tr PF00083.24 CCF40326.1 - 3.9e-56 190.8 1.8 4.8e-56 190.5 1.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF40326.1 - 4e-11 42.5 7.6 4.8e-11 42.2 7.6 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF3188 PF11384.8 CCF40326.1 - 0.011 15.4 0.1 0.048 13.4 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3188) TctB PF07331.11 CCF40326.1 - 0.79 10.0 9.6 6.2 7.1 1.2 2.6 1 1 1 2 2 2 0 Tripartite tricarboxylate transporter TctB family DUF1011 PF06237.12 CCF40326.1 - 3.8 7.9 8.7 0.17 12.2 2.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1011) Mitofilin PF09731.9 CCF40328.1 - 2.6e-147 492.4 27.3 4e-125 419.1 22.4 2.0 2 0 0 2 2 2 2 Mitochondrial inner membrane protein DUF1848 PF08902.11 CCF40328.1 - 0.091 12.5 1.0 0.2 11.3 1.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1848) DUF3496 PF12001.8 CCF40328.1 - 2.3 8.6 10.3 0.57 10.6 6.7 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3496) Tubulin PF00091.25 CCF40329.1 - 0.52 10.5 4.6 1 9.5 0.7 2.0 1 1 0 2 2 2 0 Tubulin/FtsZ family, GTPase domain RTP1_C1 PF10363.9 CCF40330.1 - 1.9e-25 89.2 1.2 3e-24 85.3 0.1 3.0 3 0 0 3 3 3 1 Required for nuclear transport of RNA pol II C-terminus 1 RTP1_C2 PF10304.9 CCF40330.1 - 5.5e-15 54.7 0.9 1.8e-14 53.1 0.9 1.9 1 0 0 1 1 1 1 Required for nuclear transport of RNA pol II C-terminus 2 Adaptin_N PF01602.20 CCF40330.1 - 0.027 13.0 0.2 0.053 12.1 0.2 1.6 1 0 0 1 1 1 0 Adaptin N terminal region XRCC4 PF06632.12 CCF40331.1 - 0.017 14.0 0.2 0.017 14.0 0.2 1.8 2 0 0 2 2 2 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 Thr_synth_N PF14821.6 CCF40333.1 - 5.6e-28 97.0 0.0 1.3e-27 95.8 0.0 1.7 1 0 0 1 1 1 1 Threonine synthase N terminus PALP PF00291.25 CCF40333.1 - 6e-19 68.5 0.0 1.3e-17 64.2 0.0 2.1 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme MCM_bind PF09739.9 CCF40334.1 - 0.061 11.8 6.5 0.033 12.6 3.9 1.7 2 0 0 2 2 2 0 Mini-chromosome maintenance replisome factor DNA_methylase PF00145.17 CCF40335.1 - 3.8e-37 128.4 0.0 6.8e-37 127.6 0.0 1.4 1 0 0 1 1 1 1 C-5 cytosine-specific DNA methylase BAH PF01426.18 CCF40335.1 - 2.4e-06 27.4 0.0 0.025 14.4 0.0 2.8 2 1 0 2 2 2 2 BAH domain DNMT1-RFD PF12047.8 CCF40335.1 - 0.14 12.2 0.0 1.3 9.1 0.0 2.2 2 0 0 2 2 2 0 Cytosine specific DNA methyltransferase replication foci domain DUF155 PF02582.14 CCF40336.1 - 1e-47 162.5 0.0 1.4e-47 162.1 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 Cupin_1 PF00190.22 CCF40336.1 - 0.13 11.8 0.0 0.23 11.1 0.0 1.4 1 0 0 1 1 1 0 Cupin DUF2681 PF10883.8 CCF40338.1 - 0.58 10.6 0.0 0.58 10.6 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) DUF4834 PF16118.5 CCF40339.1 - 0.0074 17.2 0.0 0.016 16.2 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) Amnionless PF14828.6 CCF40339.1 - 0.022 13.6 0.0 0.028 13.3 0.0 1.1 1 0 0 1 1 1 0 Amnionless DUF4106 PF13388.6 CCF40339.1 - 0.42 9.8 5.9 0.58 9.3 5.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) Astro_capsid_p PF12226.8 CCF40339.1 - 4.5 6.3 6.9 6.4 5.8 6.9 1.1 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Nexin_C PF08628.12 CCF40340.1 - 4e-29 101.4 0.1 1.5e-28 99.6 0.1 2.1 1 0 0 1 1 1 1 Sorting nexin C terminal PXA PF02194.15 CCF40340.1 - 5.9e-29 101.3 0.3 4e-28 98.6 0.0 2.7 3 0 0 3 3 3 1 PXA domain PX PF00787.24 CCF40340.1 - 2.3e-20 72.7 0.5 5.8e-20 71.4 0.5 1.7 1 0 0 1 1 1 1 PX domain RGS PF00615.19 CCF40340.1 - 2.3e-11 44.0 0.1 7.8e-11 42.3 0.1 2.0 1 0 0 1 1 1 1 Regulator of G protein signaling domain Amidohydro_1 PF01979.20 CCF40341.1 - 2.4e-29 102.8 0.0 3.9e-29 102.0 0.0 1.3 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 CCF40341.1 - 9.8e-13 48.4 1.1 2.6e-08 33.8 0.1 2.4 2 1 0 2 2 2 2 Amidohydrolase family Cupin_2 PF07883.11 CCF40342.1 - 1.9e-10 40.3 0.5 2.4e-10 40.0 0.5 1.2 1 0 0 1 1 1 1 Cupin domain Cupin_7 PF12973.7 CCF40342.1 - 0.00017 21.4 0.1 0.00023 21.0 0.1 1.2 1 0 0 1 1 1 1 ChrR Cupin-like domain AraC_binding PF02311.19 CCF40342.1 - 0.00029 20.8 0.4 0.00038 20.4 0.4 1.1 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_3 PF05899.12 CCF40342.1 - 0.00062 19.4 0.0 0.00094 18.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF861) Cupin_6 PF12852.7 CCF40342.1 - 0.0011 18.7 0.8 0.0014 18.3 0.8 1.1 1 0 0 1 1 1 1 Cupin Cupin_1 PF00190.22 CCF40342.1 - 0.032 13.8 0.0 0.036 13.7 0.0 1.1 1 0 0 1 1 1 0 Cupin Zip PF02535.22 CCF40343.1 - 1.5e-35 123.0 31.0 1.1e-14 54.4 2.5 3.1 2 1 1 3 3 3 3 ZIP Zinc transporter Deltameth_res PF16020.5 CCF40343.1 - 0.29 11.0 1.0 1 9.3 0.0 2.5 2 0 0 2 2 2 0 Deltamethrin resistance HSP70 PF00012.20 CCF40346.1 - 9.7e-264 876.1 15.5 1.1e-263 875.9 15.5 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 CCF40346.1 - 1.8e-17 63.2 2.4 1.1e-16 60.5 0.5 2.1 2 0 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.6 CCF40346.1 - 0.00015 22.2 4.5 0.36 11.3 0.2 3.6 3 1 0 3 3 3 2 Cell division protein FtsA DDR PF08841.10 CCF40346.1 - 0.0067 15.5 0.3 0.12 11.4 0.1 2.2 2 0 0 2 2 2 1 Diol dehydratase reactivase ATPase-like domain Hydantoinase_A PF01968.18 CCF40346.1 - 0.0077 15.5 2.8 0.15 11.3 0.1 3.1 3 0 0 3 3 3 1 Hydantoinase/oxoprolinase Pyr_redox_2 PF07992.14 CCF40347.1 - 2.1e-38 132.3 0.2 2.9e-38 131.8 0.2 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCF40347.1 - 2e-10 41.0 2.0 2.1e-09 37.8 0.1 2.7 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCF40347.1 - 9.7e-06 25.0 0.0 1.8e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CCF40347.1 - 5.9e-05 22.4 0.1 0.00014 21.2 0.1 1.5 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.14 CCF40347.1 - 0.0022 16.8 5.5 0.2 10.3 0.1 3.2 3 1 1 4 4 4 2 HI0933-like protein Lycopene_cycl PF05834.12 CCF40347.1 - 0.0032 16.6 0.1 0.018 14.1 0.0 2.2 3 0 0 3 3 3 1 Lycopene cyclase protein Trp_halogenase PF04820.14 CCF40347.1 - 0.0072 15.2 0.5 5.4 5.7 0.1 3.1 2 1 1 3 3 3 1 Tryptophan halogenase AlaDh_PNT_C PF01262.21 CCF40347.1 - 0.032 13.5 0.2 3.4 6.9 0.0 2.4 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_9 PF13454.6 CCF40347.1 - 0.065 13.2 0.3 26 4.8 0.0 3.8 3 1 1 4 4 4 0 FAD-NAD(P)-binding DAO PF01266.24 CCF40347.1 - 0.11 12.1 0.5 3.6 7.1 0.0 3.0 4 0 0 4 4 4 0 FAD dependent oxidoreductase GIDA PF01134.22 CCF40347.1 - 1.1 8.3 6.7 1.6 7.7 0.0 3.2 4 0 0 4 4 4 0 Glucose inhibited division protein A AAA_12 PF13087.6 CCF40348.1 - 2.5e-32 112.1 0.0 3.8e-32 111.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 CCF40348.1 - 3.7e-07 30.2 0.1 6.2e-07 29.5 0.1 1.3 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 CCF40348.1 - 0.00081 19.2 0.0 0.49 10.1 0.0 2.2 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase Methyltransf_23 PF13489.6 CCF40349.1 - 3.5e-20 72.5 0.0 5.5e-20 71.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF40349.1 - 2.8e-13 50.4 0.0 7.2e-13 49.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF40349.1 - 3.1e-12 46.6 0.0 4.4e-11 42.8 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF40349.1 - 1.8e-10 41.4 0.0 4.1e-10 40.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF40349.1 - 1.2e-08 35.5 0.0 1e-07 32.6 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCF40349.1 - 0.00062 19.2 0.0 0.49 9.7 0.0 2.2 2 0 0 2 2 2 2 ubiE/COQ5 methyltransferase family FtsJ PF01728.19 CCF40349.1 - 0.0015 18.7 0.0 0.0072 16.5 0.0 1.9 1 1 1 2 2 2 1 FtsJ-like methyltransferase Methyltransf_4 PF02390.17 CCF40349.1 - 0.0021 17.5 0.0 0.013 15.0 0.0 2.0 2 0 0 2 2 2 1 Putative methyltransferase MTS PF05175.14 CCF40349.1 - 0.0098 15.5 0.0 0.018 14.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 CCF40349.1 - 0.01 15.3 0.0 0.015 14.7 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_16 PF10294.9 CCF40349.1 - 0.02 14.7 0.0 0.031 14.0 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_2 PF00891.18 CCF40349.1 - 0.18 11.1 0.0 2 7.7 0.0 2.3 3 0 0 3 3 3 0 O-methyltransferase domain RTA1 PF04479.13 CCF40351.1 - 1.3e-64 217.6 10.9 1.7e-64 217.2 10.9 1.1 1 0 0 1 1 1 1 RTA1 like protein Tmemb_40 PF10160.9 CCF40351.1 - 0.0014 18.2 0.5 0.0029 17.1 0.5 1.5 1 0 0 1 1 1 1 Predicted membrane protein DUF5367 PF17329.2 CCF40351.1 - 4.7 7.4 9.0 0.94 9.6 0.6 3.3 3 1 1 4 4 4 0 Family of unknown function (DUF5367) Rieske PF00355.26 CCF40352.1 - 8.5e-09 35.3 0.0 1.4e-08 34.6 0.0 1.4 1 1 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.6 CCF40352.1 - 2.3e-05 24.2 0.0 3.9e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain TFIIF_alpha PF05793.12 CCF40353.1 - 0.00081 18.1 15.6 0.0012 17.5 15.6 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Myc_target_1 PF15179.6 CCF40353.1 - 0.058 13.3 1.6 4.6 7.1 0.0 2.8 2 0 0 2 2 2 0 Myc target protein 1 RIFIN PF02009.16 CCF40353.1 - 0.12 12.3 0.0 0.54 10.1 0.0 1.9 2 0 0 2 2 2 0 Rifin Mpp10 PF04006.12 CCF40353.1 - 0.93 7.9 16.3 1.4 7.3 16.3 1.2 1 0 0 1 1 1 0 Mpp10 protein Nop14 PF04147.12 CCF40353.1 - 5.3 5.1 22.1 8.1 4.5 22.1 1.2 1 0 0 1 1 1 0 Nop14-like family SPT6_acidic PF14632.6 CCF40354.1 - 1.1e-21 77.2 32.8 1.1e-21 77.2 32.8 3.0 2 1 1 3 3 3 3 Acidic N-terminal SPT6 Spore_coat_CotO PF14153.6 CCF40354.1 - 1.1 9.1 14.5 1.4 8.8 14.5 1.2 1 0 0 1 1 1 0 Spore coat protein CotO Fumble PF03630.14 CCF40355.1 - 2.2e-144 480.7 0.0 2.8e-144 480.4 0.0 1.1 1 0 0 1 1 1 1 Fumble Chromo PF00385.24 CCF40356.1 - 0.0014 18.5 0.1 0.0022 17.8 0.1 1.3 1 1 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain SRP40_C PF05022.12 CCF40357.1 - 8.4e-23 81.0 0.5 8.4e-23 81.0 0.5 2.4 2 0 0 2 2 2 1 SRP40, C-terminal domain A_deaminase PF00962.22 CCF40358.1 - 3.4e-22 79.2 0.0 4.6e-22 78.8 0.0 1.1 1 0 0 1 1 1 1 Adenosine/AMP deaminase NUDIX PF00293.28 CCF40361.1 - 1.7e-08 34.6 0.0 2.3e-08 34.2 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain VRR_NUC PF08774.11 CCF40363.1 - 1.1e-22 80.1 0.0 3e-22 78.7 0.0 1.7 1 0 0 1 1 1 1 VRR-NUC domain Solute_trans_a PF03619.16 CCF40365.1 - 9.5e-87 290.9 24.5 1.1e-86 290.6 24.5 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha K_oxygenase PF13434.6 CCF40366.1 - 9.3e-14 51.3 0.0 1.4e-08 34.3 0.0 2.3 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 CCF40366.1 - 6.1e-09 35.5 0.0 0.02 14.1 0.0 3.6 3 1 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CCF40366.1 - 1.7e-08 34.1 0.0 0.00039 19.8 0.1 2.7 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCF40366.1 - 3.6e-06 26.8 2.7 0.002 17.8 2.6 3.2 1 1 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 CCF40366.1 - 0.00058 19.2 0.0 0.051 12.8 0.0 2.3 2 0 0 2 2 2 1 FAD binding domain NAD_binding_9 PF13454.6 CCF40366.1 - 0.0016 18.5 0.0 0.04 13.9 0.0 2.6 2 0 0 2 2 2 1 FAD-NAD(P)-binding Lycopene_cycl PF05834.12 CCF40366.1 - 0.011 14.8 0.1 0.022 13.8 0.1 1.5 1 0 0 1 1 1 0 Lycopene cyclase protein Thi4 PF01946.17 CCF40366.1 - 0.012 14.8 0.0 0.023 13.9 0.0 1.4 1 0 0 1 1 1 0 Thi4 family Pyr_redox PF00070.27 CCF40366.1 - 0.017 15.7 0.2 13 6.4 0.0 3.6 4 0 0 4 4 3 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CCF40366.1 - 0.024 13.4 0.0 0.28 9.9 0.0 2.2 2 0 0 2 2 2 0 HI0933-like protein NAD_binding_8 PF13450.6 CCF40366.1 - 0.09 13.0 0.2 0.64 10.3 0.0 2.4 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Peptidase_M20 PF01546.28 CCF40367.1 - 2e-31 109.3 0.0 3.4e-31 108.6 0.0 1.4 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 CCF40367.1 - 1.9e-14 53.5 0.0 4.4e-14 52.3 0.0 1.7 2 0 0 2 2 2 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 CCF40367.1 - 0.035 13.8 0.0 0.08 12.6 0.0 1.5 1 1 0 1 1 1 0 Peptidase family M28 Peptidase_S9 PF00326.21 CCF40368.1 - 6.1e-16 58.5 0.0 1e-15 57.8 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 CCF40368.1 - 9.7e-07 28.8 0.1 4.2e-06 26.8 0.1 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold DLH PF01738.18 CCF40368.1 - 4.1e-05 23.2 0.0 8.4e-05 22.2 0.0 1.5 1 0 0 1 1 1 1 Dienelactone hydrolase family Hydrolase_4 PF12146.8 CCF40368.1 - 0.0026 17.1 0.0 0.077 12.3 0.0 2.1 1 1 1 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CCF40368.1 - 0.0061 16.2 0.0 0.61 9.7 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 CCF40368.1 - 0.035 12.9 0.0 0.051 12.4 0.0 1.2 1 0 0 1 1 1 0 Steryl acetyl hydrolase FSH1 PF03959.13 CCF40368.1 - 0.078 12.6 0.0 0.11 12.2 0.0 1.4 1 1 0 1 1 1 0 Serine hydrolase (FSH1) Sugar_tr PF00083.24 CCF40369.1 - 5.3e-126 421.1 27.0 6.1e-126 420.9 27.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF40369.1 - 4.6e-20 71.9 55.2 6.3e-17 61.5 35.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily SirB PF04247.12 CCF40369.1 - 0.089 12.9 0.4 0.089 12.9 0.4 3.1 4 0 0 4 4 4 0 Invasion gene expression up-regulator, SirB Myb_DNA-binding PF00249.31 CCF40371.1 - 1.2e-20 73.5 14.7 3.1e-11 43.3 0.1 4.6 4 1 0 4 4 4 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CCF40371.1 - 1.2e-17 63.9 1.6 3.1e-08 33.7 0.1 2.7 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.6 CCF40371.1 - 0.00076 19.8 6.7 0.0036 17.6 0.2 3.5 3 0 0 3 3 3 1 Myb/SANT-like DNA-binding domain SANT_DAMP1_like PF16282.5 CCF40371.1 - 0.14 12.4 0.2 0.66 10.2 0.0 2.2 1 1 1 2 2 2 0 SANT/Myb-like domain of DAMP1 SWIRM-assoc_2 PF16496.5 CCF40373.1 - 0.28 10.0 0.7 0.36 9.6 0.7 1.1 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal Methyltransf_23 PF13489.6 CCF40375.1 - 3.8e-12 46.3 0.0 4.6e-12 46.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF40375.1 - 3.5e-05 24.4 0.0 0.00017 22.2 0.0 2.1 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF40375.1 - 4.3e-05 23.4 0.0 0.00072 19.4 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF40375.1 - 0.00067 20.3 0.0 0.0011 19.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF40375.1 - 0.01 16.6 0.0 0.082 13.7 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 CCF40375.1 - 0.1 12.1 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain BTB PF00651.31 CCF40376.1 - 3.9e-06 27.1 0.0 7.3e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain FKBP_C PF00254.28 CCF40377.1 - 4.4e-14 52.6 0.1 7.9e-14 51.8 0.1 1.4 1 1 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase 2OG-FeII_Oxy PF03171.20 CCF40378.1 - 4.3e-22 78.5 0.1 1.3e-21 77.0 0.0 1.8 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 CCF40378.1 - 3.3e-20 73.0 0.0 5.3e-20 72.3 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal NiFeSe_Hases PF00374.19 CCF40378.1 - 0.042 12.7 0.0 0.052 12.4 0.0 1.1 1 0 0 1 1 1 0 Nickel-dependent hydrogenase CorA PF01544.18 CCF40380.1 - 3.9e-12 46.1 0.0 9.1e-12 44.9 0.0 1.5 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein Cep57_CLD_2 PF14197.6 CCF40380.1 - 2.6 8.2 5.9 1.4 9.0 0.4 2.4 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 Stm1_N PF09598.10 CCF40380.1 - 3 8.8 8.3 0.72 10.8 2.3 2.8 2 0 0 2 2 2 0 Stm1 Spc7 PF08317.11 CCF40381.1 - 0.00015 20.7 195.9 0.011 14.6 14.5 9.3 1 1 9 10 10 10 7 Spc7 kinetochore protein Sec2p PF06428.11 CCF40381.1 - 0.0015 18.4 4.6 0.0015 18.4 4.6 15.3 3 2 9 14 14 14 2 GDP/GTP exchange factor Sec2p Filament PF00038.21 CCF40381.1 - 0.0077 15.8 167.0 0.045 13.3 34.9 7.2 1 1 5 6 6 6 5 Intermediate filament protein AAA_5 PF07728.14 CCF40381.1 - 0.048 13.6 0.1 0.19 11.7 0.1 2.1 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) DUF211 PF02680.14 CCF40381.1 - 1.2 9.3 4.3 2.8 8.1 0.1 3.3 2 1 1 3 3 3 0 Uncharacterized ArCR, COG1888 GSP_synth PF03738.14 CCF40382.1 - 1.2e-110 370.3 0.0 1.4e-110 370.1 0.0 1.0 1 0 0 1 1 1 1 Glutathionylspermidine synthase preATP-grasp CSN8_PSD8_EIF3K PF10075.9 CCF40383.1 - 9.7e-20 71.0 0.0 1.5e-19 70.4 0.0 1.3 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family Dehydratase_hem PF13816.6 CCF40383.1 - 0.16 11.4 0.0 0.23 10.8 0.0 1.2 1 0 0 1 1 1 0 Haem-containing dehydratase Coatomer_WDAD PF04053.14 CCF40384.1 - 1.1e-145 486.1 0.0 2.4e-145 485.0 0.0 1.5 1 0 0 1 1 1 1 Coatomer WD associated region COPI_C PF06957.11 CCF40384.1 - 5.8e-100 334.9 0.0 8.1e-100 334.4 0.0 1.1 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus WD40 PF00400.32 CCF40384.1 - 3e-35 119.6 15.2 2.5e-07 31.3 0.2 7.5 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF40384.1 - 3.4e-09 36.9 0.8 0.0016 18.7 0.0 5.9 3 2 4 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CCF40384.1 - 0.015 13.9 6.9 2.4 6.7 0.1 3.9 2 1 1 4 4 4 0 Nucleoporin Nup120/160 Clathrin PF00637.20 CCF40384.1 - 0.077 12.9 0.2 0.67 9.8 0.0 2.3 2 0 0 2 2 2 0 Region in Clathrin and VPS IPPT PF01715.17 CCF40384.1 - 0.16 11.8 0.0 0.31 10.8 0.0 1.4 1 0 0 1 1 1 0 IPP transferase Thioredoxin_14 PF18402.1 CCF40385.1 - 8.2e-71 238.9 0.3 5.4e-70 236.2 0.2 2.3 2 1 1 3 3 3 1 Thioredoxin-like domain Thioredoxin_13 PF18401.1 CCF40385.1 - 1.4e-47 161.0 0.4 1.7e-45 154.3 0.1 2.8 3 0 0 3 3 3 1 Thioredoxin-like domain Thioredoxin_12 PF18400.1 CCF40385.1 - 3.8e-47 160.6 0.0 2.3e-46 158.1 0.0 2.3 3 0 0 3 3 3 1 Thioredoxin-like domain Thioredoxin_15 PF18403.1 CCF40385.1 - 9.8e-36 123.7 0.0 3.5e-34 118.6 0.0 2.8 3 0 0 3 3 3 1 Thioredoxin-like domain Cyclin_C_2 PF16899.5 CCF40386.1 - 1.3e-36 125.1 0.1 4.5e-34 116.9 0.0 2.5 2 0 0 2 2 2 2 Cyclin C-terminal domain Cyclin_N PF00134.23 CCF40386.1 - 0.00046 19.9 0.1 0.0012 18.6 0.0 1.6 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 CCF40386.1 - 0.07 13.2 0.2 5.8 7.0 0.0 3.2 4 0 0 4 4 4 0 Cyclin, C-terminal domain ATG11 PF10377.9 CCF40387.1 - 2.6e-46 156.8 0.1 2.6e-46 156.8 0.1 4.5 5 1 0 5 5 5 1 Autophagy-related protein 11 Tropomyosin PF00261.20 CCF40387.1 - 2.3e-05 23.9 10.2 2.3e-05 23.9 10.2 5.2 1 1 2 4 4 4 1 Tropomyosin Spc7 PF08317.11 CCF40387.1 - 2.5e-05 23.3 75.3 0.00027 19.9 17.2 4.5 1 1 3 4 4 4 3 Spc7 kinetochore protein KxDL PF10241.9 CCF40387.1 - 0.01 16.1 0.8 0.01 16.1 0.8 6.4 5 2 1 7 7 7 0 Uncharacterized conserved protein CENP-F_leu_zip PF10473.9 CCF40387.1 - 0.01 15.9 16.2 0.01 15.9 16.2 5.9 2 1 4 6 6 6 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF3584 PF12128.8 CCF40387.1 - 0.13 9.7 70.5 0.12 9.9 32.6 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) EzrA PF06160.12 CCF40387.1 - 0.53 8.4 55.7 0.017 13.3 19.3 2.4 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA Shugoshin_N PF07558.11 CCF40387.1 - 1.9 8.4 16.5 17 5.4 0.2 5.7 5 1 1 6 6 6 0 Shugoshin N-terminal coiled-coil region adh_short PF00106.25 CCF40389.1 - 1.5e-17 63.7 0.0 6e-16 58.5 0.0 2.0 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF40389.1 - 5.1e-10 39.3 0.2 1.1e-08 34.9 0.2 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF40389.1 - 7.7e-06 25.9 0.0 1.3e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF40389.1 - 0.11 11.9 0.0 0.13 11.7 0.0 1.3 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CCF40389.1 - 0.14 11.5 0.0 0.25 10.7 0.0 1.4 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase UFD1 PF03152.14 CCF40390.1 - 8.1e-69 230.5 0.0 1e-68 230.2 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 GYF PF02213.16 CCF40391.1 - 2.5e-11 43.0 2.6 6.6e-11 41.7 2.6 1.7 1 0 0 1 1 1 1 GYF domain GYF_2 PF14237.6 CCF40391.1 - 0.02 14.7 0.2 0.047 13.5 0.2 1.6 1 0 0 1 1 1 0 GYF domain 2 NACHT PF05729.12 CCF40392.1 - 3.8e-11 43.2 0.0 8.3e-11 42.1 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 CCF40392.1 - 3.2e-07 30.9 0.0 9.5e-07 29.3 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain Abhydrolase_6 PF12697.7 CCF40392.1 - 2e-06 28.6 0.2 3.6e-06 27.7 0.2 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF676 PF05057.14 CCF40392.1 - 0.00021 20.9 0.0 0.00039 20.0 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) DUF726 PF05277.12 CCF40392.1 - 0.00053 19.0 0.0 0.00085 18.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF726) AAA_22 PF13401.6 CCF40392.1 - 0.0014 18.9 0.0 0.0047 17.2 0.0 1.9 1 1 0 1 1 1 1 AAA domain Hydrolase_4 PF12146.8 CCF40392.1 - 0.0018 17.6 0.0 0.0032 16.8 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 AAA PF00004.29 CCF40392.1 - 0.0028 18.1 0.0 0.021 15.2 0.0 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Cutinase PF01083.22 CCF40392.1 - 0.0058 16.6 0.0 0.01 15.8 0.0 1.4 1 0 0 1 1 1 1 Cutinase RNA_helicase PF00910.22 CCF40392.1 - 0.014 15.8 0.0 0.049 14.0 0.0 1.9 2 0 0 2 2 2 0 RNA helicase KAP_NTPase PF07693.14 CCF40392.1 - 0.017 14.4 0.3 0.17 11.1 0.0 2.1 1 1 0 2 2 2 0 KAP family P-loop domain Lipase_3 PF01764.25 CCF40392.1 - 0.021 14.7 0.0 0.049 13.5 0.0 1.6 1 0 0 1 1 1 0 Lipase (class 3) APS_kinase PF01583.20 CCF40392.1 - 0.17 11.8 0.1 0.38 10.6 0.1 1.6 1 0 0 1 1 1 0 Adenylylsulphate kinase Abhydrolase_3 PF07859.13 CCF40392.1 - 0.18 11.6 0.0 0.33 10.8 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold HAD_2 PF13419.6 CCF40393.1 - 4.5e-24 85.5 0.0 6.4e-24 85.0 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CCF40393.1 - 6.6e-13 49.4 0.0 2.7e-12 47.5 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CCF40393.1 - 2.2e-06 27.6 0.0 5.7e-06 26.3 0.0 1.7 2 0 0 2 2 2 1 HAD-hyrolase-like NIF PF03031.18 CCF40393.1 - 0.0019 18.0 0.0 0.15 11.9 0.0 2.3 1 1 0 1 1 1 1 NLI interacting factor-like phosphatase HAD PF12710.7 CCF40393.1 - 0.0024 18.3 0.0 0.0042 17.5 0.0 1.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hypoth_Ymh PF09509.10 CCF40393.1 - 0.067 13.1 0.0 0.19 11.6 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (Hypoth_ymh) Prefoldin PF02996.17 CCF40393.1 - 0.068 13.1 0.1 0.11 12.4 0.1 1.3 1 0 0 1 1 1 0 Prefoldin subunit GH131_N PF18271.1 CCF40394.1 - 1.1e-21 77.6 0.0 1.2e-21 77.5 0.0 1.0 1 0 0 1 1 1 1 Glycoside hydrolase 131 catalytic N-terminal domain SurE PF01975.17 CCF40395.1 - 3.3e-44 151.0 0.0 4.1e-44 150.7 0.0 1.1 1 0 0 1 1 1 1 Survival protein SurE CEP170_C PF15308.6 CCF40397.1 - 0.023 13.3 1.9 0.031 12.9 1.9 1.1 1 0 0 1 1 1 0 CEP170 C-terminus Myb_DNA-bind_5 PF13873.6 CCF40397.1 - 0.13 12.4 0.2 0.3 11.2 0.2 1.5 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain PRA1 PF03208.19 CCF40398.1 - 6.8e-35 119.8 0.7 1e-34 119.2 0.7 1.2 1 0 0 1 1 1 1 PRA1 family protein RRN3 PF05327.11 CCF40398.1 - 5.7 5.4 8.3 7.9 4.9 8.3 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Astro_capsid_p PF12226.8 CCF40398.1 - 6 5.9 13.0 10 5.2 13.0 1.4 1 0 0 1 1 1 0 Turkey astrovirus capsid protein CSRNP_N PF16019.5 CCF40399.1 - 0.54 10.1 3.7 1.5 8.7 3.7 1.7 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus PCI PF01399.27 CCF40400.1 - 2e-22 79.7 0.8 4.6e-22 78.5 0.5 1.8 2 0 0 2 2 2 1 PCI domain RPN6_C_helix PF18503.1 CCF40400.1 - 8.9e-09 34.9 0.5 1.9e-08 33.9 0.5 1.6 1 0 0 1 1 1 1 26S proteasome subunit RPN6 C-terminal helix domain DDRGK PF09756.9 CCF40400.1 - 1.4e-05 24.7 1.0 2.5e-05 24.0 1.0 1.3 1 0 0 1 1 1 1 DDRGK domain TPR_12 PF13424.6 CCF40400.1 - 0.00098 19.4 11.1 0.24 11.7 0.4 4.1 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 CCF40400.1 - 0.0027 17.7 0.4 17 5.8 0.2 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 CCF40400.1 - 0.0034 17.5 1.4 6.9 7.2 0.1 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 CCF40400.1 - 0.0041 16.9 0.1 1.1 9.2 0.1 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 CCF40400.1 - 0.0075 16.2 2.2 0.05 13.7 0.6 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.6 CCF40400.1 - 0.019 14.8 0.6 7.1 6.6 0.1 4.0 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_MalT PF17874.1 CCF40400.1 - 0.052 12.9 0.4 0.052 12.9 0.4 2.6 1 1 0 2 2 2 0 MalT-like TPR region HTH_Crp_2 PF13545.6 CCF40400.1 - 0.081 12.9 0.0 0.22 11.6 0.0 1.8 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain TPR_4 PF07721.14 CCF40400.1 - 0.12 13.1 0.1 0.66 10.8 0.0 2.4 2 0 0 2 2 1 0 Tetratricopeptide repeat DUF4398 PF14346.6 CCF40400.1 - 0.15 12.7 6.7 0.51 11.0 0.3 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4398) DUF2564 PF10819.8 CCF40400.1 - 2 8.8 6.3 4 7.9 1.6 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2564) SIS PF01380.22 CCF40401.1 - 4.9e-10 39.4 0.0 8.1e-10 38.7 0.0 1.3 1 0 0 1 1 1 1 SIS domain HECT PF00632.25 CCF40402.1 - 1.4e-94 317.1 0.0 1.8e-94 316.7 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.26 CCF40402.1 - 1.5e-34 117.8 24.7 7e-13 48.4 6.3 4.0 4 0 0 4 4 4 3 WW domain C2 PF00168.30 CCF40402.1 - 6.9e-19 68.1 0.1 2e-18 66.6 0.1 1.8 1 0 0 1 1 1 1 C2 domain DUF3292 PF11696.8 CCF40403.1 - 6.5e-211 702.2 0.1 7.8e-211 701.9 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3292) DUF4141 PF13605.6 CCF40403.1 - 0.033 13.4 1.6 0.039 13.2 0.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4141) Pectate_lyase PF03211.13 CCF40404.1 - 2.5e-83 278.6 11.9 2.9e-83 278.4 11.9 1.0 1 0 0 1 1 1 1 Pectate lyase Ribosomal_S8 PF00410.19 CCF40406.1 - 6.1e-13 48.8 0.0 5.9e-12 45.7 0.0 2.0 1 1 0 1 1 1 1 Ribosomal protein S8 WD40 PF00400.32 CCF40407.1 - 6.1e-45 150.3 18.1 7e-07 29.8 0.4 8.5 8 0 0 8 8 8 7 WD domain, G-beta repeat F-box-like PF12937.7 CCF40407.1 - 3.6e-13 49.2 0.1 7.1e-13 48.2 0.1 1.5 1 0 0 1 1 1 1 F-box-like Nup160 PF11715.8 CCF40407.1 - 4.6e-13 48.7 2.9 0.014 14.1 0.1 4.2 2 2 1 4 4 4 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 CCF40407.1 - 3.5e-10 40.0 0.3 0.29 11.5 0.0 6.5 2 2 5 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain F-box PF00646.33 CCF40407.1 - 7.7e-10 38.4 0.0 2e-09 37.1 0.0 1.7 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 CCF40407.1 - 4.5e-05 23.3 0.0 0.00014 21.8 0.0 1.8 1 0 0 1 1 1 1 F-box BBS2_Mid PF14783.6 CCF40407.1 - 0.0049 16.9 0.0 0.78 9.8 0.0 3.7 3 2 1 4 4 4 1 Ciliary BBSome complex subunit 2, middle region WD40_like PF17005.5 CCF40407.1 - 0.0068 15.8 0.1 0.8 9.0 0.0 2.4 2 1 0 3 3 3 1 WD40-like domain BRK PF07533.16 CCF40407.1 - 0.025 14.2 0.1 21 4.8 0.0 3.7 4 0 0 4 4 4 0 BRK domain Ge1_WD40 PF16529.5 CCF40407.1 - 0.57 9.1 3.4 37 3.1 0.0 4.4 4 2 2 6 6 6 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PALB2_WD40 PF16756.5 CCF40407.1 - 0.91 8.4 3.9 15 4.4 0.1 3.6 2 2 2 4 4 4 0 Partner and localizer of BRCA2 WD40 domain NTP_transf_2 PF01909.23 CCF40408.1 - 0.027 14.7 0.0 0.034 14.4 0.0 1.2 1 0 0 1 1 1 0 Nucleotidyltransferase domain NR_Repeat PF14046.6 CCF40409.1 - 2.2 8.5 0.0 2.2 8.5 0.0 2.8 3 0 0 3 3 3 0 Nuclear receptor repeat DotD PF16816.5 CCF40410.1 - 0.018 15.0 0.0 0.026 14.5 0.0 1.2 1 0 0 1 1 1 0 DotD protein NFACT-C PF11923.8 CCF40411.1 - 1e-41 141.2 0.4 1e-41 141.2 0.4 3.6 2 1 1 3 3 3 1 NFACT protein C-terminal domain NFACT-R_1 PF05670.13 CCF40411.1 - 1.5e-33 115.7 0.3 4e-33 114.3 0.0 1.9 2 0 0 2 2 2 1 NFACT protein RNA binding domain FbpA PF05833.11 CCF40411.1 - 1.4e-29 103.2 17.4 1.4e-29 103.2 17.4 2.5 2 1 0 2 2 2 1 Fibronectin-binding protein A N-terminus (FbpA) TFIIF_alpha PF05793.12 CCF40411.1 - 0.00011 21.0 3.6 0.00011 21.0 3.6 2.3 2 0 0 2 2 2 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) TFIIA PF03153.13 CCF40412.1 - 0.00011 22.4 26.1 0.00011 22.4 26.1 2.1 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit EPL1 PF10513.9 CCF40412.1 - 0.12 12.8 13.2 0.023 15.1 4.4 3.1 3 0 0 3 3 3 0 Enhancer of polycomb-like eIF-3_zeta PF05091.12 CCF40412.1 - 0.3 10.0 11.3 0.49 9.3 11.3 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SID-1_RNA_chan PF13965.6 CCF40412.1 - 0.59 8.5 0.9 0.99 7.7 0.9 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Connexin PF00029.19 CCF40412.1 - 4 7.1 7.3 7.5 6.2 7.3 1.4 1 0 0 1 1 1 0 Connexin RR_TM4-6 PF06459.12 CCF40412.1 - 4.6 7.0 9.5 11 5.7 9.5 1.6 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CLN3 PF02487.17 CCF40412.1 - 4.7 6.1 5.9 8.1 5.4 5.9 1.3 1 0 0 1 1 1 0 CLN3 protein Globin PF00042.22 CCF40415.1 - 1.9e-09 38.1 0.0 3e-09 37.4 0.0 1.3 1 0 0 1 1 1 1 Globin NAD_binding_1 PF00175.21 CCF40415.1 - 2.6e-07 31.3 0.0 4.8e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 CCF40415.1 - 7.5e-05 23.0 0.0 0.00014 22.2 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain Protoglobin PF11563.8 CCF40415.1 - 0.00054 19.9 0.1 0.00082 19.3 0.1 1.3 1 0 0 1 1 1 1 Protoglobin NAD_binding_6 PF08030.12 CCF40415.1 - 0.0076 16.4 0.0 0.021 15.0 0.0 1.7 1 1 0 1 1 1 1 Ferric reductase NAD binding domain Fer4_2 PF12797.7 CCF40416.1 - 0.19 11.9 0.6 0.19 11.9 0.6 2.8 4 0 0 4 4 4 0 4Fe-4S binding domain p450 PF00067.22 CCF40417.1 - 2.3e-54 184.9 0.0 2.4e-54 184.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 FAD_binding_3 PF01494.19 CCF40420.1 - 5e-18 65.5 0.1 3.7e-10 39.6 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 CCF40420.1 - 1.9e-10 40.9 1.7 0.00014 21.6 0.1 2.2 1 1 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCF40420.1 - 9.8e-06 25.0 0.0 2.5e-05 23.7 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CCF40420.1 - 0.00011 21.1 0.4 0.0099 14.6 0.1 2.1 2 0 0 2 2 2 2 HI0933-like protein Lycopene_cycl PF05834.12 CCF40420.1 - 0.00029 20.0 0.9 0.0015 17.7 0.9 1.9 1 1 0 1 1 1 1 Lycopene cyclase protein FAD_binding_2 PF00890.24 CCF40420.1 - 0.00047 19.4 2.7 0.0023 17.1 0.5 2.1 1 1 1 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.6 CCF40420.1 - 0.0022 18.2 0.1 0.0057 16.9 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 CCF40420.1 - 0.0022 17.4 1.2 0.086 12.1 0.0 2.6 3 0 0 3 3 3 1 Flavin containing amine oxidoreductase Pyr_redox PF00070.27 CCF40420.1 - 0.036 14.6 0.1 5.3 7.7 0.1 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 CCF40420.1 - 0.084 11.7 0.0 0.15 10.9 0.0 1.4 2 0 0 2 2 2 0 Tryptophan halogenase Pyr_redox_3 PF13738.6 CCF40420.1 - 0.21 10.8 0.0 0.29 10.3 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase RNA_pol_Rpc4 PF05132.14 CCF40421.1 - 3.2e-19 69.8 0.1 3.7e-19 69.6 0.1 1.0 1 0 0 1 1 1 1 RNA polymerase III RPC4 Abhydrolase_7 PF12715.7 CCF40422.1 - 0.14 11.4 0.0 0.19 11.0 0.0 1.1 1 0 0 1 1 1 0 Abhydrolase family Glyco_hydro_63 PF03200.16 CCF40423.1 - 1.8e-07 30.3 9.8 3e-06 26.3 0.1 4.4 5 1 0 5 5 5 2 Glycosyl hydrolase family 63 C-terminal domain TTSSLRR PF12468.8 CCF40423.1 - 0.11 12.7 0.1 0.3 11.4 0.1 1.6 1 0 0 1 1 1 0 Type III secretion system leucine rich repeat protein Hep_59 PF07052.11 CCF40423.1 - 0.17 12.7 1.2 0.35 11.6 1.2 1.6 1 0 0 1 1 1 0 Hepatocellular carcinoma-associated antigen 59 MFS_1 PF07690.16 CCF40424.1 - 1.1e-28 100.2 21.3 1.3e-28 99.9 21.3 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Cellulase PF00150.18 CCF40426.1 - 6.9e-50 170.0 4.2 9.7e-50 169.6 4.2 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) CBM_1 PF00734.18 CCF40426.1 - 8.8e-12 44.8 11.3 8.8e-12 44.8 11.3 2.5 2 0 0 2 2 2 1 Fungal cellulose binding domain SSP160 PF06933.11 CCF40426.1 - 0.49 8.5 13.2 0.063 11.5 8.5 1.8 2 0 0 2 2 2 0 Special lobe-specific silk protein SSP160 MGC-24 PF05283.11 CCF40426.1 - 1.8 9.0 6.6 3.4 8.1 6.6 1.4 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin FAD_binding_7 PF03441.14 CCF40427.1 - 2.7e-75 252.3 0.1 2.9e-75 252.2 0.1 1.0 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DUF4045 PF13254.6 CCF40428.1 - 1.8e-89 301.3 51.4 5.6e-57 194.3 37.0 7.1 3 2 3 7 7 7 2 Domain of unknown function (DUF4045) Gelsolin PF00626.22 CCF40428.1 - 0.017 15.0 0.1 0.12 12.2 0.0 2.4 2 0 0 2 2 2 0 Gelsolin repeat CTU2 PF10288.9 CCF40429.1 - 0.045 14.0 1.1 0.055 13.7 1.1 1.1 1 0 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 Arf PF00025.21 CCF40430.1 - 3.4e-62 209.0 0.3 3.8e-62 208.8 0.3 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 CCF40430.1 - 4.4e-09 36.0 0.5 0.0015 17.8 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 CCF40430.1 - 1.4e-08 34.6 0.0 1.6e-08 34.3 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCF40430.1 - 3.9e-07 30.3 0.1 8.5e-07 29.2 0.1 1.5 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 CCF40430.1 - 2e-06 27.3 0.0 2.4e-06 27.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 CCF40430.1 - 1.1e-05 24.9 0.0 1.5e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 CCF40430.1 - 1.5e-05 25.0 0.0 4.8e-05 23.4 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CCF40430.1 - 0.0058 16.2 0.0 0.12 11.9 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain NACHT PF05729.12 CCF40430.1 - 0.018 15.0 0.2 0.2 11.6 0.0 2.0 2 0 0 2 2 2 0 NACHT domain Dynamin_N PF00350.23 CCF40430.1 - 0.044 13.8 0.0 0.75 9.8 0.0 2.1 2 0 0 2 2 2 0 Dynamin family PduV-EutP PF10662.9 CCF40430.1 - 0.11 12.3 0.0 0.21 11.3 0.0 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation 6PF2K PF01591.18 CCF40430.1 - 0.15 11.4 0.1 0.38 10.0 0.1 1.6 2 0 0 2 2 2 0 6-phosphofructo-2-kinase Acetyltransf_7 PF13508.7 CCF40431.1 - 0.0044 17.4 0.0 0.012 16.1 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CCF40431.1 - 0.1 12.8 0.0 0.29 11.4 0.0 1.8 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family SNAP-25 PF00835.19 CCF40431.1 - 0.17 12.2 3.8 3 8.2 1.6 2.8 2 0 0 2 2 2 0 SNAP-25 family Ecl1 PF12855.7 CCF40433.1 - 1.7e-13 52.1 21.8 3.1e-13 51.3 21.8 1.3 1 1 0 1 1 1 1 ECL1/2/3 zinc binding proteins HipA_C PF07804.12 CCF40433.1 - 0.07 12.8 0.1 0.088 12.5 0.1 1.1 1 0 0 1 1 1 0 HipA-like C-terminal domain zf-MYND PF01753.18 CCF40433.1 - 0.075 13.1 1.8 0.14 12.3 1.8 1.4 1 0 0 1 1 1 0 MYND finger Tho1_MOS11_C PF18592.1 CCF40434.1 - 1.8e-07 30.8 1.8 1.8e-07 30.8 1.8 2.3 2 0 0 2 2 2 1 Tho1/MOS11 C-terminal domain Ank_2 PF12796.7 CCF40435.1 - 1.4e-56 189.0 4.0 1.5e-11 44.7 0.1 6.9 3 1 1 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CCF40435.1 - 2.1e-46 155.7 7.4 2.9e-06 27.7 0.0 10.3 4 2 5 10 10 10 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCF40435.1 - 4e-39 128.1 12.2 0.00088 19.6 0.0 13.5 14 0 0 14 14 14 9 Ankyrin repeat Ank_5 PF13857.6 CCF40435.1 - 2.8e-37 126.3 12.5 2.4e-07 30.9 0.0 9.5 5 2 4 9 9 9 9 Ankyrin repeats (many copies) Ank PF00023.30 CCF40435.1 - 2.6e-28 97.2 24.2 0.0031 17.9 0.3 13.3 12 1 0 12 12 12 8 Ankyrin repeat FCD PF07729.12 CCF40435.1 - 5.5 7.4 6.8 28 5.1 0.0 3.7 4 1 0 4 4 4 0 FCD domain TPR_8 PF13181.6 CCF40436.1 - 8.1e-07 28.8 0.3 0.00093 19.2 0.0 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 CCF40436.1 - 4.6e-05 23.2 0.2 0.01 15.9 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 CCF40436.1 - 9.6e-05 22.6 0.2 0.00028 21.1 0.2 1.8 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 CCF40436.1 - 0.00068 19.4 0.2 0.074 12.9 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 CCF40436.1 - 0.0025 18.3 0.4 0.0078 16.7 0.4 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_10 PF13374.6 CCF40436.1 - 0.008 16.0 0.1 0.13 12.2 0.1 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 CCF40436.1 - 0.013 16.1 2.3 0.036 14.7 0.6 2.4 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 CCF40436.1 - 0.035 13.8 0.2 0.49 10.1 0.0 2.6 3 0 0 3 3 3 0 TPR repeat DUF5633 PF18656.1 CCF40436.1 - 0.04 13.8 0.9 0.078 12.9 0.0 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5633) TPR_14 PF13428.6 CCF40436.1 - 0.051 14.4 5.5 2.6 9.1 0.2 3.2 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 CCF40436.1 - 0.091 12.8 0.5 5.9 7.2 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TRP PF06011.12 CCF40437.1 - 2.3e-22 79.4 18.6 2.2e-21 76.1 19.6 2.0 2 1 0 2 2 2 1 Transient receptor potential (TRP) ion channel RFamide_26RFa PF11109.8 CCF40437.1 - 0.15 12.5 1.6 0.19 12.2 0.1 1.8 2 0 0 2 2 2 0 Orexigenic neuropeptide Qrfp/P518 Cellulase PF00150.18 CCF40438.1 - 4e-10 39.6 2.3 4e-10 39.6 2.3 1.5 2 0 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) Radical_SAM PF04055.21 CCF40438.1 - 0.026 14.9 0.0 0.079 13.3 0.0 1.8 1 0 0 1 1 1 0 Radical SAM superfamily EphA2_TM PF14575.6 CCF40438.1 - 0.036 14.9 0.0 0.036 14.9 0.0 2.3 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Adipogenin PF15202.6 CCF40438.1 - 0.042 13.9 0.0 0.084 12.9 0.0 1.5 1 0 0 1 1 1 0 Adipogenin DUF4064 PF13273.6 CCF40438.1 - 0.064 13.5 0.0 0.13 12.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) TMEM154 PF15102.6 CCF40438.1 - 0.19 11.6 0.0 0.44 10.4 0.0 1.5 1 0 0 1 1 1 0 TMEM154 protein family Synaptobrevin PF00957.21 CCF40438.1 - 3 7.7 3.8 5.4 6.9 3.8 1.4 1 0 0 1 1 1 0 Synaptobrevin SNARE PF05739.19 CCF40438.1 - 3.3 7.8 6.5 8 6.5 6.5 1.6 1 0 0 1 1 1 0 SNARE domain PsaX PF08078.12 CCF40438.1 - 7.8 6.6 5.5 8.1 6.5 0.0 2.3 2 0 0 2 2 2 0 PsaX family Transket_pyr PF02779.24 CCF40439.1 - 4.7e-20 72.0 0.1 6.6e-20 71.5 0.1 1.2 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain MCR_gamma PF02240.16 CCF40439.1 - 0.012 14.9 0.3 0.019 14.2 0.3 1.3 1 0 0 1 1 1 0 Methyl-coenzyme M reductase gamma subunit MFS_1 PF07690.16 CCF40440.1 - 3.7e-28 98.5 11.5 4.4e-28 98.2 11.5 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 CCF40440.1 - 5.5e-06 25.9 4.5 7.5e-06 25.5 4.5 1.1 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB DUF2157 PF09925.9 CCF40440.1 - 0.93 9.3 5.4 3.1 7.6 5.4 1.8 1 1 0 1 1 1 0 Predicted membrane protein (DUF2157) ECH_2 PF16113.5 CCF40441.1 - 0.051 13.1 0.0 0.059 12.8 0.0 1.0 1 0 0 1 1 1 0 Enoyl-CoA hydratase/isomerase Peptidase_M22 PF00814.25 CCF40442.1 - 0.025 14.3 0.3 0.038 13.7 0.3 1.2 1 0 0 1 1 1 0 Glycoprotease family Cut8 PF08559.10 CCF40442.1 - 0.11 12.1 0.0 0.16 11.6 0.0 1.1 1 0 0 1 1 1 0 Cut8, nuclear proteasome tether protein ABC_membrane PF00664.23 CCF40443.1 - 4.2e-85 285.7 33.1 1.7e-53 182.1 16.6 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 CCF40443.1 - 4.2e-66 221.6 0.0 1.5e-31 109.7 0.0 2.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 CCF40443.1 - 1.5e-13 50.7 0.0 2.8e-05 23.6 0.0 3.3 1 1 1 3 3 3 2 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 CCF40443.1 - 4.5e-08 33.2 0.0 0.022 14.7 0.0 3.5 3 0 0 3 3 3 2 RsgA GTPase AAA_16 PF13191.6 CCF40443.1 - 4.9e-08 33.5 0.2 0.0055 17.1 0.0 3.0 2 1 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 CCF40443.1 - 3.4e-07 29.9 1.3 0.0033 17.1 0.3 3.3 3 0 0 3 3 3 2 P-loop containing region of AAA domain AAA_25 PF13481.6 CCF40443.1 - 3.9e-05 23.3 0.1 0.27 10.8 0.1 3.1 2 0 0 2 2 2 2 AAA domain ABC_ATPase PF09818.9 CCF40443.1 - 4.7e-05 22.4 1.4 0.13 11.0 0.1 2.9 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA_22 PF13401.6 CCF40443.1 - 8.4e-05 22.9 0.7 0.2 11.9 0.0 3.3 2 2 0 2 2 2 2 AAA domain AAA_15 PF13175.6 CCF40443.1 - 0.0001 22.2 0.1 0.47 10.1 0.0 2.5 3 0 0 3 3 2 2 AAA ATPase domain AAA PF00004.29 CCF40443.1 - 0.00023 21.6 1.9 4.1 7.8 0.1 4.5 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_21 PF13304.6 CCF40443.1 - 0.00063 19.7 0.4 2.1 8.1 0.0 3.5 3 1 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system Zeta_toxin PF06414.12 CCF40443.1 - 0.00073 18.9 0.1 1.3 8.3 0.0 2.8 3 0 0 3 3 2 2 Zeta toxin AAA_30 PF13604.6 CCF40443.1 - 0.0021 17.8 3.3 1.9 8.2 0.1 3.9 4 1 0 4 4 3 2 AAA domain SbcCD_C PF13558.6 CCF40443.1 - 0.0022 18.2 1.7 3.4 8.0 0.2 3.7 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit APS_kinase PF01583.20 CCF40443.1 - 0.0038 17.1 0.0 2.3 8.1 0.0 3.7 3 1 1 4 4 4 1 Adenylylsulphate kinase G-alpha PF00503.20 CCF40443.1 - 0.0039 16.4 0.0 2.3 7.3 0.0 2.4 2 0 0 2 2 2 2 G-protein alpha subunit AAA_28 PF13521.6 CCF40443.1 - 0.0049 17.1 0.7 0.48 10.6 0.1 2.7 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 CCF40443.1 - 0.005 16.8 0.1 7.9 6.5 0.0 3.4 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 CCF40443.1 - 0.0087 16.2 0.0 6.7 6.9 0.0 2.8 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 CCF40443.1 - 0.0094 15.5 0.0 2.9 7.3 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region DUF87 PF01935.17 CCF40443.1 - 0.015 15.4 2.1 4.3 7.4 0.1 2.9 3 0 0 3 3 3 0 Helicase HerA, central domain AAA_18 PF13238.6 CCF40443.1 - 0.024 15.2 0.0 12 6.5 0.0 2.8 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 CCF40443.1 - 0.042 14.3 2.4 1.8 9.0 0.0 3.1 3 1 0 3 3 3 0 AAA domain DUF815 PF05673.13 CCF40443.1 - 0.069 12.3 0.1 7.2 5.7 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF815) AAA_24 PF13479.6 CCF40443.1 - 0.073 12.8 0.0 6.1 6.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 CCF40443.1 - 0.11 12.9 0.0 13 6.2 0.0 3.0 2 0 0 2 2 2 0 RNA helicase Rad17 PF03215.15 CCF40443.1 - 0.15 11.9 0.0 0.93 9.4 0.0 2.1 2 0 0 2 2 2 0 Rad17 P-loop domain MMR_HSR1 PF01926.23 CCF40443.1 - 0.5 10.5 3.6 5.6 7.1 0.0 3.0 3 0 0 3 3 2 0 50S ribosome-binding GTPase WD40 PF00400.32 CCF40444.1 - 2.8e-22 78.6 1.3 1.3e-10 41.7 0.0 2.5 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF40444.1 - 2.5e-07 30.9 0.0 0.00036 20.8 0.0 2.2 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CCF40444.1 - 2.9e-06 26.5 0.4 0.0043 16.1 0.0 2.1 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 CCF40444.1 - 0.0044 15.7 0.0 0.019 13.6 0.1 1.7 1 1 1 2 2 2 1 Nucleoporin Nup120/160 Big_3_5 PF16640.5 CCF40444.1 - 0.59 10.3 4.1 2.8 8.2 4.1 1.9 1 1 0 1 1 1 0 Bacterial Ig-like domain (group 3) Aldedh PF00171.22 CCF40445.1 - 4.3e-122 408.0 0.0 7.2e-122 407.2 0.0 1.3 1 1 0 1 1 1 1 Aldehyde dehydrogenase family Imm49 PF15575.6 CCF40445.1 - 0.16 11.7 0.1 0.28 10.9 0.1 1.3 1 0 0 1 1 1 0 Immunity protein 49 BRO1 PF03097.18 CCF40446.1 - 7.7e-12 44.7 0.1 1e-11 44.3 0.1 1.1 1 0 0 1 1 1 1 BRO1-like domain Alg6_Alg8 PF03155.15 CCF40447.1 - 2.2e-128 429.3 27.4 1.6e-80 271.5 12.1 2.2 2 0 0 2 2 2 2 ALG6, ALG8 glycosyltransferase family Utp12 PF04003.12 CCF40448.1 - 5.7e-21 74.8 0.1 9.6e-21 74.1 0.1 1.3 1 0 0 1 1 1 1 Dip2/Utp12 Family WD40 PF00400.32 CCF40448.1 - 0.012 16.5 0.0 0.023 15.6 0.0 1.5 1 0 0 1 1 1 0 WD domain, G-beta repeat Pkinase PF00069.25 CCF40449.1 - 5e-17 62.1 0.0 6.5e-17 61.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF40449.1 - 1.9e-10 40.5 0.0 2.2e-10 40.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF40449.1 - 0.00042 19.7 0.0 0.0013 18.1 0.0 1.6 1 1 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.11 CCF40449.1 - 0.023 13.8 0.1 0.033 13.2 0.1 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Choline_kinase PF01633.20 CCF40449.1 - 0.11 12.1 0.1 0.14 11.7 0.1 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase POTRA_3 PF17287.2 CCF40449.1 - 0.11 12.0 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 POTRA domain APH PF01636.23 CCF40449.1 - 0.11 12.4 0.1 0.16 11.9 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 CCF40449.1 - 0.13 11.6 0.3 0.2 11.0 0.3 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF446 PF04287.12 CCF40450.1 - 0.13 12.4 0.3 0.25 11.4 0.2 1.5 1 1 1 2 2 2 0 tRNA pseudouridine synthase C SnoaL_4 PF13577.6 CCF40451.1 - 3e-13 50.0 0.6 4.4e-13 49.5 0.6 1.2 1 0 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.6 CCF40451.1 - 0.074 13.5 1.2 0.12 12.8 1.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4440) DUF3636 PF12331.8 CCF40452.1 - 6.2e-42 142.9 0.2 1.3e-41 141.9 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3636) Golgin_A5 PF09787.9 CCF40452.1 - 0.23 10.9 6.7 0.39 10.2 6.7 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 TMF_TATA_bd PF12325.8 CCF40452.1 - 0.42 10.9 5.0 0.78 10.0 5.0 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding DUF4407 PF14362.6 CCF40452.1 - 0.58 9.5 6.2 1.2 8.4 6.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Defensin_like PF10868.8 CCF40454.1 - 4.3e-11 43.4 10.2 5e-11 43.2 10.2 1.1 1 0 0 1 1 1 1 Cysteine-rich antifungal protein 2, defensin-like Methyltransf_2 PF00891.18 CCF40455.1 - 1.6e-27 96.2 0.0 2.4e-27 95.6 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain FAD_binding_3 PF01494.19 CCF40455.1 - 4.5e-08 32.7 0.0 0.0018 17.6 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 CCF40455.1 - 0.00092 19.4 0.0 0.0024 18.0 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Methyltransf_25 PF13649.6 CCF40455.1 - 0.034 14.8 0.0 0.079 13.7 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Lactamase_B_5 PF14597.6 CCF40456.1 - 0.13 11.7 0.0 0.19 11.2 0.0 1.2 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily GAF_2 PF13185.6 CCF40458.1 - 6.3e-06 26.5 0.1 1.1e-05 25.8 0.1 1.2 1 1 0 1 1 1 1 GAF domain GAF PF01590.26 CCF40458.1 - 0.00062 20.4 0.1 0.00073 20.2 0.1 1.0 1 0 0 1 1 1 1 GAF domain Spermine_synth PF01564.17 CCF40459.1 - 6.5e-75 250.7 0.0 1.1e-74 249.9 0.0 1.3 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Spermine_synt_N PF17284.2 CCF40459.1 - 1.1e-20 73.2 0.1 1.9e-20 72.5 0.1 1.4 1 0 0 1 1 1 1 Spermidine synthase tetramerisation domain Methyltransf_25 PF13649.6 CCF40459.1 - 0.00058 20.5 0.0 0.0012 19.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF40459.1 - 0.0048 17.6 0.2 0.032 15.0 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain DUF43 PF01861.16 CCF40459.1 - 0.0049 16.1 0.0 0.0079 15.4 0.0 1.3 1 0 0 1 1 1 1 Branched-chain polyamine synthase A C-terminal domain Methyltransf_18 PF12847.7 CCF40459.1 - 0.096 12.6 0.0 0.18 11.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain SAM_3 PF18016.1 CCF40460.1 - 0.17 11.7 0.3 0.37 10.6 0.3 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Ank_4 PF13637.6 CCF40461.1 - 1.2e-23 83.2 0.1 1.1e-13 51.4 0.0 2.6 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 CCF40461.1 - 2.9e-22 79.1 0.0 9.2e-17 61.4 0.0 2.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CCF40461.1 - 2e-19 69.4 1.1 3.9e-11 43.0 0.1 2.8 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCF40461.1 - 8.5e-17 59.5 0.0 2.2e-05 24.5 0.0 4.0 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.30 CCF40461.1 - 1.7e-14 53.5 0.1 1.1e-06 28.7 0.0 3.5 4 0 0 4 4 4 3 Ankyrin repeat Nitro_FeMo-Co PF02579.17 CCF40461.1 - 0.06 13.7 0.2 0.44 10.9 0.0 1.9 1 1 1 2 2 2 0 Dinitrogenase iron-molybdenum cofactor Pkinase PF00069.25 CCF40463.1 - 5.5e-71 239.0 0.0 7.5e-71 238.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF40463.1 - 6e-34 117.5 0.0 8.2e-34 117.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 CCF40463.1 - 2.4e-13 50.5 1.3 6.9e-13 49.1 1.3 1.8 1 0 0 1 1 1 1 Protein kinase C terminal domain Haspin_kinase PF12330.8 CCF40463.1 - 4.1e-06 26.0 0.0 6.2e-06 25.4 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain C2 PF00168.30 CCF40463.1 - 0.0061 16.8 0.0 0.014 15.6 0.0 1.6 1 0 0 1 1 1 1 C2 domain Kinase-like PF14531.6 CCF40463.1 - 0.0095 15.3 0.0 0.022 14.1 0.0 1.6 2 0 0 2 2 2 1 Kinase-like FTA2 PF13095.6 CCF40463.1 - 0.06 13.0 0.1 0.73 9.4 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 CCF40463.1 - 0.15 11.4 0.1 0.3 10.4 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Peptidase_S10 PF00450.22 CCF40464.1 - 8.8e-87 292.2 0.0 1.1e-86 291.9 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase RRM_1 PF00076.22 CCF40465.1 - 1e-38 131.0 0.0 1.6e-18 66.2 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CCF40465.1 - 3.4e-06 27.1 0.0 0.082 13.0 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif DUF4140 PF13600.6 CCF40465.1 - 0.069 13.6 0.0 0.069 13.6 0.0 3.5 3 1 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) Macoilin PF09726.9 CCF40465.1 - 3 6.3 30.7 4.4 5.8 30.7 1.2 1 0 0 1 1 1 0 Macoilin family LAP1C PF05609.12 CCF40465.1 - 4.3 6.3 33.9 6.8 5.7 33.9 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) NDUFB10 PF10249.9 CCF40466.1 - 0.0039 17.7 0.0 0.0046 17.5 0.0 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit 10 HWE_HK PF07536.14 CCF40466.1 - 0.12 13.1 0.0 0.17 12.6 0.0 1.2 1 0 0 1 1 1 0 HWE histidine kinase Ribosomal_L37 PF08561.10 CCF40467.1 - 1.2e-41 142.0 1.3 2e-41 141.3 1.3 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L37 TAFII55_N PF04658.13 CCF40468.1 - 1e-47 161.9 2.4 1.2e-47 161.6 0.0 2.1 2 0 0 2 2 2 1 TAFII55 protein conserved region GPI-anchored PF10342.9 CCF40469.1 - 8.2e-07 29.7 0.1 2.3e-06 28.3 0.1 1.8 1 0 0 1 1 1 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family SWI-SNF_Ssr4 PF08549.10 CCF40470.1 - 8.1e-218 725.6 18.1 4.8e-217 723.0 18.1 1.8 1 1 0 1 1 1 1 Fungal domain of unknown function (DUF1750) Vir_act_alpha_C PF10400.9 CCF40470.1 - 1.3 9.7 7.6 1 10.1 1.0 2.7 3 0 0 3 3 3 0 Virulence activator alpha C-term HrpB7 PF09486.10 CCF40470.1 - 8.1 6.8 9.9 12 6.2 1.1 2.3 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) zf-C2H2_aberr PF17017.5 CCF40471.1 - 1.8e-05 25.0 2.0 0.017 15.3 0.2 2.2 2 0 0 2 2 2 2 Aberrant zinc-finger zf-C2H2 PF00096.26 CCF40471.1 - 0.00057 20.2 10.1 0.18 12.3 0.8 3.4 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCF40471.1 - 0.0015 19.2 11.5 0.13 13.2 0.6 3.6 3 0 0 3 3 3 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 CCF40471.1 - 0.0083 16.5 9.3 0.089 13.3 0.5 3.2 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_jaz PF12171.8 CCF40471.1 - 0.053 13.8 1.1 5.5 7.4 0.1 2.8 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding TAL_FSA PF00923.19 CCF40472.1 - 1.2e-39 136.4 0.0 1.3e-39 136.2 0.0 1.1 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase Transp_cyt_pur PF02133.15 CCF40473.1 - 4.5e-80 269.6 34.0 5.1e-80 269.4 34.0 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin DUF3487 PF11990.8 CCF40473.1 - 9.7 6.1 8.2 5.4 6.9 1.6 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3487) SSF PF00474.17 CCF40474.1 - 3.9e-23 82.0 24.6 5.3e-23 81.5 24.6 1.1 1 0 0 1 1 1 1 Sodium:solute symporter family SieB PF14163.6 CCF40474.1 - 5 6.6 5.6 16 5.0 0.0 3.1 3 0 0 3 3 3 0 Super-infection exclusion protein B Mit_KHE1 PF10173.9 CCF40475.1 - 1 9.4 0.0 1 9.4 0.0 3.0 4 0 0 4 4 4 0 Mitochondrial K+-H+ exchange-related Lactamase_B PF00753.27 CCF40476.1 - 3.9e-20 72.7 1.9 4.7e-20 72.4 1.9 1.1 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CCF40476.1 - 0.0083 15.7 0.1 0.013 15.0 0.1 1.5 1 1 0 1 1 1 1 Beta-lactamase superfamily domain EthD PF07110.11 CCF40477.1 - 1.2e-06 29.6 0.1 2.3e-06 28.6 0.1 1.5 1 1 0 1 1 1 1 EthD domain Fungal_trans_2 PF11951.8 CCF40479.1 - 2.9e-09 36.2 0.0 3.6e-09 35.9 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Ufm1 PF03671.14 CCF40479.1 - 0.0037 17.3 0.0 0.0086 16.1 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin fold modifier 1 protein Zn_clus PF00172.18 CCF40480.1 - 1.8e-07 31.2 10.2 3.2e-07 30.4 10.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Helicase_PWI PF18149.1 CCF40481.1 - 2.8e-05 24.3 0.0 4.1e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 N-terminal helicase PWI domain Synaptobrevin PF00957.21 CCF40482.1 - 2.9e-14 52.6 0.6 4.2e-14 52.1 0.6 1.2 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 CCF40482.1 - 1.2e-12 47.6 0.0 2.7e-12 46.5 0.0 1.6 1 1 0 1 1 1 1 Regulated-SNARE-like domain Cnd2 PF05786.14 CCF40483.1 - 0 1018.6 7.5 0 1018.4 7.5 1.1 1 0 0 1 1 1 1 Condensin complex subunit 2 TIMELESS_C PF05029.13 CCF40483.1 - 0.028 13.6 10.8 0.048 12.8 10.8 1.3 1 0 0 1 1 1 0 Timeless protein C terminal region CNDH2_N PF06278.11 CCF40483.1 - 0.044 14.0 0.0 0.044 14.0 0.0 2.6 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal TraH_2 PF06871.11 CCF40483.1 - 0.76 9.4 4.2 1.6 8.3 4.2 1.5 1 0 0 1 1 1 0 TraH_2 Vfa1 PF08432.10 CCF40483.1 - 4.9 7.5 8.1 15 5.9 0.8 2.5 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 DUF1751 PF08551.10 CCF40484.1 - 0.028 15.0 0.5 0.051 14.2 0.1 1.6 1 1 0 1 1 1 0 Eukaryotic integral membrane protein (DUF1751) DER1 PF04511.15 CCF40484.1 - 0.034 14.1 1.2 0.039 13.9 1.2 1.1 1 0 0 1 1 1 0 Der1-like family Prenyltransf PF01255.19 CCF40485.1 - 6.2e-82 274.5 0.0 9.8e-82 273.8 0.0 1.2 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase MSA-2c PF12238.8 CCF40485.1 - 0.032 14.2 0.3 0.044 13.8 0.3 1.2 1 0 0 1 1 1 0 Merozoite surface antigen 2c ING PF12998.7 CCF40486.1 - 5.1e-08 33.4 0.0 0.00079 20.0 0.0 2.5 2 0 0 2 2 2 2 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 CCF40486.1 - 5.2e-06 26.2 7.8 8.8e-06 25.5 7.8 1.4 1 0 0 1 1 1 1 PHD-finger GatB_Yqey PF02637.18 CCF40486.1 - 0.044 13.7 0.0 0.14 12.0 0.0 1.9 1 0 0 1 1 1 0 GatB domain zf-HC5HC2H PF13771.6 CCF40486.1 - 0.07 13.4 3.3 0.14 12.4 3.3 1.5 1 0 0 1 1 1 0 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 CCF40486.1 - 0.26 11.5 2.3 0.53 10.5 2.3 1.4 1 0 0 1 1 1 0 PHD-zinc-finger like domain PHD_2 PF13831.6 CCF40486.1 - 0.36 10.4 3.2 0.66 9.6 3.2 1.4 1 0 0 1 1 1 0 PHD-finger PRIMA1 PF16101.5 CCF40487.1 - 1.7 8.7 5.5 0.84 9.7 2.1 1.9 1 1 1 2 2 2 0 Proline-rich membrane anchor 1 LRR_4 PF12799.7 CCF40488.1 - 0.015 15.7 0.2 0.54 10.8 0.0 3.5 3 0 0 3 3 3 0 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 CCF40488.1 - 0.018 15.0 0.0 12 6.3 0.0 4.2 4 0 0 4 4 4 0 Leucine Rich repeat LRR_8 PF13855.6 CCF40488.1 - 0.039 13.7 0.9 2.6 7.9 0.0 3.4 4 0 0 4 4 4 0 Leucine rich repeat F-box-like PF12937.7 CCF40488.1 - 0.048 13.6 0.0 0.11 12.4 0.0 1.7 1 0 0 1 1 1 0 F-box-like AflR PF08493.10 CCF40488.1 - 0.091 12.2 10.8 0.17 11.3 10.8 1.4 1 0 0 1 1 1 0 Aflatoxin regulatory protein Pectate_lyase_3 PF12708.7 CCF40489.1 - 5.9e-22 78.6 0.4 7.3e-22 78.3 0.4 1.1 1 0 0 1 1 1 1 Pectate lyase superfamily protein End_N_terminal PF12218.8 CCF40489.1 - 0.044 13.5 0.4 0.078 12.7 0.4 1.5 1 0 0 1 1 1 0 N terminal extension of bacteriophage endosialidase DUF3405 PF11885.8 CCF40492.1 - 3.1e-191 636.5 0.0 3.1e-191 636.5 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF3405) APG6_N PF17675.1 CCF40492.1 - 0.0045 17.5 24.2 0.0094 16.5 24.2 1.5 1 0 0 1 1 1 1 Apg6 coiled-coil region UPF0242 PF06785.11 CCF40492.1 - 0.0058 16.8 9.9 0.009 16.1 9.9 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus Asp-B-Hydro_N PF05279.11 CCF40492.1 - 0.23 11.5 20.5 0.37 10.8 20.5 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region HSP70 PF00012.20 CCF40492.1 - 0.63 8.2 12.8 0.91 7.6 12.8 1.1 1 0 0 1 1 1 0 Hsp70 protein DUF3450 PF11932.8 CCF40492.1 - 1.2 8.3 16.1 2.1 7.6 16.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DUF4407 PF14362.6 CCF40492.1 - 3.2 7.0 12.3 5.2 6.3 12.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Fmp27_WPPW PF10359.9 CCF40492.1 - 7.8 5.2 12.3 32 3.2 12.9 1.6 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain APG12 PF04110.13 CCF40495.1 - 1.3e-28 99.3 0.0 1.6e-28 98.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Atg8 PF02991.16 CCF40495.1 - 4.9e-07 29.9 0.0 5.9e-07 29.6 0.0 1.1 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like Pantoate_transf PF02548.15 CCF40496.1 - 6.8e-106 353.4 0.2 8e-106 353.2 0.2 1.0 1 0 0 1 1 1 1 Ketopantoate hydroxymethyltransferase PEP_mutase PF13714.6 CCF40496.1 - 1.1e-08 34.9 0.7 1.9e-08 34.1 0.1 1.6 2 0 0 2 2 2 1 Phosphoenolpyruvate phosphomutase DUF4861 PF16153.5 CCF40496.1 - 0.018 14.0 0.0 0.026 13.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4861) TRI12 PF06609.13 CCF40497.1 - 2.2e-08 33.0 3.4 2.4e-08 32.9 3.4 1.0 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_1 PF07690.16 CCF40497.1 - 2.5e-06 26.7 20.1 3.2e-06 26.3 20.1 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF4516 PF14990.6 CCF40497.1 - 0.47 10.2 2.4 1.9 8.3 0.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4516) TOM13 PF08219.11 CCF40497.1 - 0.52 10.3 1.9 5.5 7.0 0.1 2.3 1 1 1 2 2 2 0 Outer membrane protein TOM13 MFS_1 PF07690.16 CCF40498.1 - 9.9e-11 41.1 14.9 2.8e-10 39.6 14.9 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 CCF40498.1 - 7.2e-10 37.9 2.8 8.3e-10 37.7 2.8 1.0 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 CCF40498.1 - 0.0012 17.8 5.6 0.0012 17.8 5.6 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter DUF5612 PF18462.1 CCF40498.1 - 0.045 13.5 0.3 0.071 12.9 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5612) DUF2301 PF10063.9 CCF40498.1 - 0.16 12.4 0.6 0.42 11.0 0.6 1.6 1 0 0 1 1 1 0 Uncharacterized integral membrane protein (DUF2301) DEAD PF00270.29 CCF40500.1 - 4.3e-13 49.4 0.0 5.4e-13 49.1 0.0 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 CCF40500.1 - 0.21 11.5 0.0 0.23 11.5 0.0 1.1 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Nic96 PF04097.14 CCF40502.1 - 3.7e-201 669.8 0.0 4.9e-201 669.4 0.0 1.1 1 0 0 1 1 1 1 Nup93/Nic96 Nucleoporin_FG PF13634.6 CCF40502.1 - 9.5e-05 23.2 87.2 0.0026 18.6 44.4 4.1 2 1 1 3 3 3 2 Nucleoporin FG repeat region zf-C2H2_jaz PF12171.8 CCF40503.1 - 0.001 19.3 1.3 0.001 19.3 1.3 3.5 4 0 0 4 4 4 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CCF40503.1 - 0.0012 19.1 0.4 0.0012 19.1 0.4 2.7 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 CCF40503.1 - 0.004 17.5 0.9 0.004 17.5 0.9 2.3 1 1 1 2 2 2 1 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.26 CCF40503.1 - 0.041 14.3 0.8 0.041 14.3 0.8 3.4 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCF40503.1 - 0.051 14.4 0.4 0.051 14.4 0.4 3.8 4 0 0 4 4 4 0 C2H2-type zinc finger zf-C2H2_8 PF15909.5 CCF40503.1 - 0.21 11.9 0.2 0.21 11.9 0.2 2.0 1 1 1 2 2 2 0 C2H2-type zinc ribbon Ran_BP1 PF00638.18 CCF40504.1 - 4.9e-50 168.9 1.6 8.3e-50 168.1 1.6 1.4 1 0 0 1 1 1 1 RanBP1 domain WH1 PF00568.23 CCF40504.1 - 0.0011 18.9 0.3 0.0041 17.0 0.3 1.8 1 1 0 1 1 1 1 WH1 domain PS-DH PF14765.6 CCF40504.1 - 0.019 14.2 0.3 0.037 13.3 0.3 1.4 1 0 0 1 1 1 0 Polyketide synthase dehydratase VID27_PH PF17747.1 CCF40504.1 - 0.1 12.9 0.0 0.15 12.3 0.0 1.4 1 1 0 1 1 1 0 VID27 PH-like domain PHD20L1_u1 PF16660.5 CCF40504.1 - 0.11 13.2 2.8 0.21 12.3 2.8 1.4 1 0 0 1 1 1 0 PHD finger protein 20-like protein 1 CDC27 PF09507.10 CCF40504.1 - 0.68 9.3 15.3 0.91 8.8 15.3 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 DUF2677 PF10838.8 CCF40505.1 - 0.0071 16.3 0.0 0.016 15.2 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2677) Orn_DAP_Arg_deC PF00278.22 CCF40505.1 - 0.12 12.7 0.0 0.75 10.1 0.0 2.2 2 1 0 2 2 2 0 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Pox_MCEL PF03291.16 CCF40506.1 - 3.5e-71 240.1 0.0 8.8e-48 163.1 0.0 2.4 2 0 0 2 2 2 2 mRNA capping enzyme Methyltransf_25 PF13649.6 CCF40506.1 - 1.3e-10 41.8 0.3 0.00011 22.8 0.0 2.8 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_12 PF08242.12 CCF40506.1 - 3.3e-09 37.4 0.1 0.0036 18.0 0.0 3.0 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_11 PF08241.12 CCF40506.1 - 7.2e-07 29.8 0.1 0.055 14.1 0.0 2.6 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.6 CCF40506.1 - 6.1e-06 26.1 0.0 0.0011 18.8 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_23 PF13489.6 CCF40506.1 - 1.5e-05 24.9 0.0 2.9e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 CCF40506.1 - 0.00032 20.0 0.0 0.00053 19.3 0.0 1.3 1 0 0 1 1 1 1 NNMT/PNMT/TEMT family CCD48 PF15799.5 CCF40506.1 - 0.0063 14.9 7.1 0.01 14.2 7.1 1.3 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 48 RPN7 PF10602.9 CCF40507.1 - 1.5e-56 190.8 2.1 1.7e-56 190.7 0.3 1.8 2 0 0 2 2 2 1 26S proteasome subunit RPN7 PCI PF01399.27 CCF40507.1 - 1.4e-15 57.7 0.0 3.3e-15 56.5 0.0 1.6 1 0 0 1 1 1 1 PCI domain TPR_14 PF13428.6 CCF40507.1 - 0.12 13.2 2.2 2.5 9.1 0.1 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat Aminotran_1_2 PF00155.21 CCF40508.1 - 6.9e-37 127.4 0.0 9.5e-37 127.0 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Pec_lyase_C PF00544.19 CCF40509.1 - 7.2e-41 140.1 3.3 1.3e-40 139.2 3.3 1.4 1 0 0 1 1 1 1 Pectate lyase Beta_helix PF13229.6 CCF40509.1 - 0.0023 17.8 7.2 0.0086 15.9 0.4 2.6 2 2 0 2 2 2 2 Right handed beta helix region Pyr_redox_3 PF13738.6 CCF40511.1 - 1.9e-11 43.8 0.1 1.1e-10 41.3 0.1 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 CCF40511.1 - 8.3e-10 37.7 0.0 1.5e-09 36.8 0.0 1.3 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 CCF40511.1 - 5.1e-09 35.8 0.0 9.1e-08 31.7 0.0 2.2 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCF40511.1 - 7.8e-08 32.4 0.0 1.4e-06 28.4 0.0 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 CCF40511.1 - 2.8e-07 30.0 0.0 4.3e-06 26.1 0.0 2.2 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 CCF40511.1 - 6.7e-07 29.2 1.0 6.9e-05 22.6 0.1 3.5 4 0 0 4 4 4 1 FAD dependent oxidoreductase Thi4 PF01946.17 CCF40511.1 - 1.3e-05 24.6 0.0 0.00077 18.8 0.0 2.3 2 0 0 2 2 2 1 Thi4 family Mqo PF06039.15 CCF40511.1 - 0.0019 16.9 0.0 0.021 13.4 0.0 2.4 2 1 1 3 3 3 1 Malate:quinone oxidoreductase (Mqo) Pyr_redox PF00070.27 CCF40511.1 - 0.0023 18.4 0.0 3.6 8.2 0.0 2.9 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 CCF40511.1 - 0.0097 15.2 0.0 0.014 14.7 0.0 1.3 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_9 PF13454.6 CCF40511.1 - 0.012 15.6 3.0 11 5.9 0.1 3.9 4 0 0 4 4 4 0 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 CCF40511.1 - 0.018 14.2 0.2 5.3 6.0 0.0 2.5 2 1 1 3 3 3 0 FAD binding domain Shikimate_DH PF01488.20 CCF40511.1 - 0.14 12.2 0.0 1.2 9.2 0.0 2.2 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Lactamase_B_2 PF12706.7 CCF40512.1 - 2.2e-07 30.6 2.7 1.3e-05 24.9 2.7 2.6 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 CCF40512.1 - 1.9e-05 24.8 0.1 3.7e-05 23.8 0.1 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Cu_amine_oxid PF01179.20 CCF40513.1 - 4.3e-161 536.4 0.0 5.3e-161 536.1 0.0 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN3 PF02728.16 CCF40513.1 - 2.2e-22 79.3 0.1 4.7e-22 78.3 0.1 1.6 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain Cu_amine_oxidN2 PF02727.16 CCF40513.1 - 1.2e-14 54.3 0.0 2e-14 53.6 0.0 1.4 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain MFS_1 PF07690.16 CCF40514.1 - 7.6e-37 127.0 26.8 4.1e-36 124.6 28.5 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily YdjM PF04307.14 CCF40514.1 - 0.39 10.0 6.4 0.46 9.8 4.6 2.0 1 1 1 2 2 2 0 LexA-binding, inner membrane-associated putative hydrolase LapA_dom PF06305.11 CCF40514.1 - 1.1 9.1 4.0 5.9 6.8 0.1 3.6 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain EBP50_C PF09007.11 CCF40515.1 - 0.016 16.2 2.2 0.016 16.2 2.2 2.4 2 0 0 2 2 2 0 EBP50, C-terminal RAP1 PF07218.11 CCF40515.1 - 0.018 13.4 1.6 0.023 13.0 1.6 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Apt1 PF10351.9 CCF40515.1 - 0.14 11.0 5.1 0.23 10.3 5.1 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain NPR3 PF03666.13 CCF40515.1 - 8 5.1 10.6 62 2.2 0.0 2.1 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 PPP4R2 PF09184.11 CCF40516.1 - 0.11 12.0 5.3 0.25 10.9 5.3 1.5 1 0 0 1 1 1 0 PPP4R2 CDC45 PF02724.14 CCF40516.1 - 0.2 9.9 6.5 0.29 9.4 6.5 1.2 1 0 0 1 1 1 0 CDC45-like protein ZapA PF05164.13 CCF40516.1 - 0.23 11.9 0.8 0.45 11.0 0.8 1.4 1 0 0 1 1 1 0 Cell division protein ZapA Nop14 PF04147.12 CCF40516.1 - 0.4 8.8 9.1 0.6 8.3 9.1 1.2 1 0 0 1 1 1 0 Nop14-like family Cwf_Cwc_15 PF04889.12 CCF40516.1 - 0.5 10.1 14.9 1 9.0 14.9 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein RXT2_N PF08595.11 CCF40516.1 - 0.57 10.2 6.7 1.1 9.2 6.7 1.4 1 0 0 1 1 1 0 RXT2-like, N-terminal DNA_pol_phi PF04931.13 CCF40516.1 - 0.61 8.1 13.0 0.84 7.7 13.0 1.1 1 0 0 1 1 1 0 DNA polymerase phi Nop53 PF07767.11 CCF40516.1 - 0.65 9.3 9.0 1 8.7 9.0 1.2 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) TFB6 PF17110.5 CCF40516.1 - 0.79 9.4 3.7 1.3 8.7 3.7 1.3 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH RNA_pol_3_Rpc31 PF11705.8 CCF40516.1 - 0.87 9.8 12.7 2.1 8.5 12.7 1.6 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 PBP1_TM PF14812.6 CCF40516.1 - 1.1 9.7 8.2 3 8.3 8.2 1.8 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal RRN3 PF05327.11 CCF40516.1 - 1.4 7.4 4.5 1.9 7.0 4.5 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 FAM176 PF14851.6 CCF40516.1 - 2.1 8.0 5.8 4.9 6.8 5.8 1.6 1 0 0 1 1 1 0 FAM176 family DUF4611 PF15387.6 CCF40516.1 - 2.8 8.2 9.7 7.5 6.8 9.7 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) SRP-alpha_N PF04086.13 CCF40516.1 - 4.2 7.2 13.9 0.68 9.8 9.5 1.8 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal NOA36 PF06524.12 CCF40516.1 - 6.4 6.0 15.9 10 5.4 15.9 1.2 1 0 0 1 1 1 0 NOA36 protein TRAP_alpha PF03896.16 CCF40516.1 - 7.6 5.6 7.7 12 5.0 7.7 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DLH PF01738.18 CCF40517.1 - 5.8e-06 26.0 0.1 6.1e-06 26.0 0.1 1.0 1 0 0 1 1 1 1 Dienelactone hydrolase family ADH_zinc_N PF00107.26 CCF40518.1 - 2.2e-25 89.1 0.1 3.6e-25 88.4 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCF40518.1 - 5e-20 72.9 0.0 7.6e-20 72.3 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCF40518.1 - 7.7e-09 35.4 0.0 3.5e-08 33.3 0.0 1.9 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain p450 PF00067.22 CCF40519.1 - 5.7e-39 134.1 0.0 1.1e-38 133.2 0.0 1.4 1 1 0 1 1 1 1 Cytochrome P450 Transp_cyt_pur PF02133.15 CCF40520.1 - 2.1e-16 59.8 2.1 2.4e-16 59.6 2.1 1.1 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin XRN_N PF03159.18 CCF40522.1 - 2.1e-97 325.3 0.0 3e-97 324.8 0.0 1.2 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus XRN_M PF17846.1 CCF40522.1 - 1.4e-41 142.9 1.4 2.6e-41 142.0 1.4 1.4 1 1 0 1 1 1 1 Xrn1 helical domain Sterile PF03015.19 CCF40522.1 - 0.092 13.0 0.0 0.97 9.7 0.0 2.6 2 1 0 2 2 2 0 Male sterility protein CAF1C_H4-bd PF12265.8 CCF40523.1 - 8.8e-26 90.0 0.2 2.7e-25 88.4 0.2 1.9 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 CCF40523.1 - 3e-12 46.9 0.1 0.00031 21.5 0.0 4.2 4 0 0 4 4 4 3 WD domain, G-beta repeat Cpn60_TCP1 PF00118.24 CCF40524.1 - 4.5e-151 503.8 6.2 5.1e-151 503.6 6.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family TetR_C_14 PF17754.1 CCF40524.1 - 0.04 13.9 0.1 4.5 7.2 0.0 2.5 2 0 0 2 2 2 0 MftR C-terminal domain EAL PF00563.20 CCF40524.1 - 0.07 12.6 0.0 0.16 11.5 0.0 1.5 1 0 0 1 1 1 0 EAL domain PP1_inhibitor PF05361.12 CCF40524.1 - 0.074 13.1 0.2 0.23 11.5 0.1 1.8 1 1 0 1 1 1 0 PKC-activated protein phosphatase-1 inhibitor MFS_1 PF07690.16 CCF40525.1 - 2e-05 23.7 20.6 5.1e-05 22.4 19.8 2.0 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF40525.1 - 0.0041 16.0 5.6 0.0041 16.0 5.6 1.6 2 0 0 2 2 2 1 Sugar (and other) transporter zf-C2H2_jaz PF12171.8 CCF40528.1 - 0.0075 16.5 0.2 0.021 15.1 0.2 1.8 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 CCF40528.1 - 0.12 13.3 7.6 0.41 11.6 0.1 3.3 3 0 0 3 3 3 0 C2H2-type zinc finger DUF4187 PF13821.6 CCF40528.1 - 0.13 12.1 1.0 0.3 10.9 0.4 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4187) zf-C2H2 PF00096.26 CCF40528.1 - 6.3 7.5 9.9 2.2 8.9 0.4 3.3 3 0 0 3 3 3 0 Zinc finger, C2H2 type Fungal_trans_2 PF11951.8 CCF40529.1 - 3.5e-10 39.3 0.5 5.2e-10 38.7 0.5 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain MutS_V PF00488.21 CCF40531.1 - 4.1e-60 203.0 0.7 7.1e-60 202.3 0.7 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 CCF40531.1 - 4e-28 98.9 0.9 4e-28 98.9 0.9 2.1 2 1 0 2 2 2 1 MutS domain III MutS_IV PF05190.18 CCF40531.1 - 4.8e-06 26.8 0.0 1.4e-05 25.4 0.0 1.9 1 0 0 1 1 1 1 MutS family domain IV AAA_27 PF13514.6 CCF40531.1 - 0.04 13.5 0.1 0.63 9.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain Pox_A32 PF04665.12 CCF40531.1 - 0.073 12.5 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 Poxvirus A32 protein Menin PF05053.13 CCF40532.1 - 0.26 9.6 21.6 0.33 9.3 21.6 1.0 1 0 0 1 1 1 0 Menin ROS_MUCR PF05443.11 CCF40533.1 - 0.071 13.2 4.0 0.12 12.4 0.1 3.1 3 1 0 3 3 3 0 ROS/MUCR transcriptional regulator protein GAT PF03127.14 CCF40533.1 - 0.17 12.2 0.2 0.17 12.2 0.2 2.4 2 0 0 2 2 2 0 GAT domain DUF5321 PF17254.2 CCF40534.1 - 5.5e-61 204.7 2.7 6.7e-61 204.4 2.7 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5321) Mur_ligase_M PF08245.12 CCF40536.1 - 2.7e-05 24.3 0.0 7e-05 22.9 0.0 1.7 1 1 0 1 1 1 1 Mur ligase middle domain Glyco_hydro_28 PF00295.17 CCF40537.1 - 5.2e-33 114.5 2.3 6.5e-33 114.2 2.3 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Beta_helix PF13229.6 CCF40537.1 - 0.00088 19.2 12.7 0.0043 16.9 12.8 2.1 1 1 1 2 2 2 1 Right handed beta helix region Spt20 PF12090.8 CCF40538.1 - 0.043 13.4 20.4 0.098 12.3 13.2 2.1 2 0 0 2 2 2 0 Spt20 family DUF533 PF04391.12 CCF40538.1 - 0.2 11.2 0.1 0.2 11.2 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF533) Fungal_trans PF04082.18 CCF40539.1 - 2e-19 69.6 0.0 4.1e-19 68.7 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain PsiA PF06952.11 CCF40541.1 - 0.08 12.2 0.0 0.24 10.6 0.0 1.6 1 1 0 2 2 2 0 PsiA protein Zn_clus PF00172.18 CCF40542.1 - 5.5e-09 36.0 9.0 8.8e-09 35.4 9.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Flu_C_NS1 PF03506.13 CCF40542.1 - 0.15 12.0 0.2 0.24 11.4 0.2 1.2 1 0 0 1 1 1 0 Influenza C non-structural protein (NS1) p450 PF00067.22 CCF40543.1 - 1.4e-56 192.2 0.0 1.8e-56 191.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Anp1 PF03452.14 CCF40544.1 - 5.9e-101 337.3 1.9 6.1e-101 337.3 0.0 1.8 2 0 0 2 2 2 1 Anp1 Smg8_Smg9 PF10220.9 CCF40544.1 - 1.1 7.5 8.0 1.4 7.2 8.0 1.1 1 0 0 1 1 1 0 Smg8_Smg9 Jnk-SapK_ap_N PF09744.9 CCF40544.1 - 1.5 9.1 18.5 0.28 11.4 14.9 1.5 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 Sec7 PF01369.20 CCF40545.1 - 5e-66 221.9 0.0 1.1e-65 220.7 0.0 1.6 2 0 0 2 2 2 1 Sec7 domain Sec7_N PF12783.7 CCF40545.1 - 5.1e-16 59.0 0.0 5e-15 55.7 0.0 2.7 2 0 0 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DCB PF16213.5 CCF40545.1 - 0.0034 17.1 0.1 0.056 13.1 0.0 2.6 2 0 0 2 2 2 1 Dimerisation and cyclophilin-binding domain of Mon2 RRM_1 PF00076.22 CCF40546.1 - 7.9e-26 89.7 0.5 5.9e-12 45.2 0.2 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CCF40546.1 - 8.1e-07 28.7 0.0 6.2e-05 22.6 0.0 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1866 PF08952.11 CCF40546.1 - 0.01 15.6 0.0 0.8 9.5 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1866) Limkain-b1 PF11608.8 CCF40546.1 - 0.032 14.3 0.0 1.8 8.7 0.0 2.6 2 0 0 2 2 2 0 Limkain b1 ATP-synt_D PF01813.17 CCF40547.1 - 9.9e-71 237.6 1.4 1.2e-70 237.3 1.4 1.1 1 0 0 1 1 1 1 ATP synthase subunit D SYCE1 PF15233.6 CCF40547.1 - 0.033 14.3 1.7 0.57 10.2 0.3 2.4 2 0 0 2 2 2 0 Synaptonemal complex central element protein 1 CobA_CobO_BtuR PF02572.15 CCF40547.1 - 0.42 10.9 3.4 0.91 9.8 0.1 2.3 2 1 1 3 3 3 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP DUF5446 PF17522.2 CCF40547.1 - 0.65 10.2 2.4 0.8 9.9 0.7 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5446) NRDE-2 PF08424.10 CCF40548.1 - 2e-05 23.9 3.1 0.017 14.2 2.5 3.6 1 1 1 2 2 2 1 NRDE-2, necessary for RNA interference Suf PF05843.14 CCF40548.1 - 4.9e-05 23.5 0.0 0.00033 20.8 0.0 2.0 1 1 1 2 2 2 1 Suppressor of forked protein (Suf) TPR_14 PF13428.6 CCF40548.1 - 0.00034 21.2 0.8 5.9 8.0 0.0 4.1 3 2 2 5 5 5 2 Tetratricopeptide repeat Egg_lysin PF01303.17 CCF40548.1 - 0.078 13.2 0.4 0.37 11.0 0.2 2.2 2 0 0 2 2 2 0 Egg lysin (Sperm-lysin) DUF2183 PF09949.9 CCF40549.1 - 6.6e-31 106.6 0.0 1.9e-30 105.1 0.0 1.9 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2183) LNS2 PF08235.13 CCF40549.1 - 0.0011 18.5 0.0 0.0025 17.3 0.0 1.5 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) AIF_C PF14721.6 CCF40549.1 - 0.43 10.9 2.3 0.42 11.0 0.1 2.0 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term HTH_32 PF13565.6 CCF40550.1 - 2.6 8.7 7.7 1 10.1 4.1 2.0 1 1 1 2 2 2 0 Homeodomain-like domain BRD4_CDT PF17105.5 CCF40550.1 - 3 7.5 6.5 1.8 8.2 2.6 2.4 2 0 0 2 2 2 0 C-terminal domain of bromodomain protein 4 SMP PF04927.12 CCF40551.1 - 5.9e-12 45.9 1.3 8.1e-08 32.6 0.0 2.7 3 0 0 3 3 3 2 Seed maturation protein CSRNP_N PF16019.5 CCF40551.1 - 0.11 12.4 0.6 0.15 12.0 0.6 1.2 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus OmdA PF13376.6 CCF40552.1 - 4.2e-21 74.7 0.9 5.5e-21 74.3 0.9 1.2 1 0 0 1 1 1 1 Bacteriocin-protection, YdeI or OmpD-Associated Sugar_tr PF00083.24 CCF40553.1 - 2.8e-90 303.3 17.9 3.6e-90 303.0 17.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF40553.1 - 4.1e-17 62.1 59.6 1.4e-13 50.5 33.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TauD PF02668.16 CCF40554.1 - 6.3e-45 154.0 0.5 8.5e-45 153.6 0.5 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF1257 PF06868.11 CCF40554.1 - 0.044 14.1 0.1 0.16 12.2 0.0 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF1257) Crl PF07417.12 CCF40554.1 - 0.066 13.3 0.0 0.19 11.8 0.0 1.7 2 0 0 2 2 2 0 Sigma factor-binding transcriptional regulator Crl Pox_mRNA-cap PF03341.13 CCF40554.1 - 0.15 11.3 0.0 0.4 9.9 0.0 1.7 1 0 0 1 1 1 0 Poxvirus mRNA capping enzyme, small subunit CAP59_mtransfer PF11735.8 CCF40555.1 - 1.1e-14 54.7 0.0 2e-14 53.8 0.0 1.4 2 0 0 2 2 2 1 Cryptococcal mannosyltransferase 1 DUF3951 PF13131.6 CCF40555.1 - 0.043 14.0 0.0 0.071 13.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3951) TALPID3 PF15324.6 CCF40555.1 - 0.65 7.6 6.2 0.8 7.3 6.2 1.0 1 0 0 1 1 1 0 Hedgehog signalling target D-ser_dehydrat PF14031.6 CCF40557.1 - 8.5e-25 87.2 0.1 1.6e-24 86.4 0.1 1.4 1 0 0 1 1 1 1 Putative serine dehydratase domain Ala_racemase_N PF01168.20 CCF40557.1 - 3e-10 40.1 0.0 5.4e-10 39.3 0.0 1.4 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain Cpn10 PF00166.21 CCF40557.1 - 0.11 12.5 0.1 0.23 11.5 0.1 1.5 1 0 0 1 1 1 0 Chaperonin 10 Kd subunit Fungal_trans_2 PF11951.8 CCF40558.1 - 1.1e-39 136.4 9.7 3.2e-39 134.8 9.7 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF40558.1 - 8.8e-05 22.5 9.0 0.00013 22.0 9.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 CCF40559.1 - 1.9e-14 53.4 48.5 2.4e-13 49.8 46.8 2.9 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_1 PF07690.16 CCF40560.1 - 1.3e-39 136.1 49.2 1.9e-31 109.3 23.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 CCF40560.1 - 0.00065 18.1 4.7 0.00093 17.6 1.1 2.7 2 1 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1_like PF12832.7 CCF40560.1 - 0.088 11.7 16.8 0.15 10.9 3.9 2.4 1 1 1 2 2 2 0 MFS_1 like family PTR2 PF00854.21 CCF40560.1 - 3.4 6.4 6.9 0.23 10.3 0.4 2.0 2 0 0 2 2 2 0 POT family CHASE2 PF05226.11 CCF40561.1 - 0.17 11.6 0.0 0.19 11.4 0.0 1.0 1 0 0 1 1 1 0 CHASE2 domain F-box PF00646.33 CCF40562.1 - 1.6e-05 24.6 1.9 2.4e-05 24.1 1.3 1.6 1 1 1 2 2 2 1 F-box domain F-box-like PF12937.7 CCF40562.1 - 2.7e-05 24.0 2.2 4.9e-05 23.1 2.2 1.5 1 0 0 1 1 1 1 F-box-like UBM PF14377.6 CCF40562.1 - 0.018 14.4 0.3 0.041 13.3 0.1 1.6 1 1 0 1 1 1 0 Ubiquitin binding region DUF3079 PF11278.8 CCF40562.1 - 0.05 13.4 0.8 0.12 12.2 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3079) PRANC PF09372.10 CCF40562.1 - 0.056 13.8 0.0 0.078 13.3 0.0 1.2 1 0 0 1 1 1 0 PRANC domain F-box_4 PF15966.5 CCF40562.1 - 0.12 12.3 0.2 0.15 11.9 0.2 1.2 1 0 0 1 1 1 0 F-box Dynamin_N PF00350.23 CCF40563.1 - 4.1e-08 33.5 0.0 5.8e-08 33.0 0.0 1.4 1 1 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 CCF40563.1 - 8.4e-05 22.6 0.0 0.00023 21.2 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.27 CCF40563.1 - 0.00019 21.9 0.0 0.00044 20.8 0.0 1.5 1 1 0 1 1 1 1 ABC transporter RsgA_GTPase PF03193.16 CCF40563.1 - 0.00091 19.2 0.0 0.0016 18.4 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase DUF87 PF01935.17 CCF40563.1 - 0.0039 17.3 1.0 0.028 14.5 0.6 2.2 1 1 1 2 2 2 1 Helicase HerA, central domain AIG1 PF04548.16 CCF40563.1 - 0.0047 16.3 0.0 0.0076 15.6 0.0 1.3 1 0 0 1 1 1 1 AIG1 family IIGP PF05049.13 CCF40563.1 - 0.016 14.3 0.1 0.052 12.6 0.1 1.7 1 1 1 2 2 2 0 Interferon-inducible GTPase (IIGP) MeaB PF03308.16 CCF40563.1 - 0.026 13.5 0.0 0.046 12.7 0.0 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_16 PF13191.6 CCF40563.1 - 0.044 14.2 0.1 0.062 13.7 0.1 1.5 1 1 0 1 1 1 0 AAA ATPase domain Adeno_IVa2 PF02456.15 CCF40563.1 - 0.066 12.0 0.0 0.094 11.5 0.0 1.1 1 0 0 1 1 1 0 Adenovirus IVa2 protein AAA_28 PF13521.6 CCF40563.1 - 0.1 12.8 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 CCF40563.1 - 0.17 12.5 0.0 0.44 11.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain Peptidase_S28 PF05577.12 CCF40564.1 - 2.8e-44 151.6 0.6 3.2e-43 148.1 0.6 2.0 1 1 0 1 1 1 1 Serine carboxypeptidase S28 DUF2920 PF11144.8 CCF40564.1 - 6.3e-05 22.3 0.0 9.6e-05 21.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2920) adh_short PF00106.25 CCF40565.1 - 8.6e-25 87.3 0.0 1.4e-24 86.7 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF40565.1 - 2.9e-15 56.5 0.1 3.8e-15 56.1 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF40565.1 - 1.2e-07 31.8 0.1 1.9e-07 31.2 0.1 1.5 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF40565.1 - 1.4e-07 31.2 0.0 2e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CCF40565.1 - 0.00012 21.6 0.0 0.00016 21.2 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 CCF40565.1 - 0.0022 17.9 0.2 0.0042 17.0 0.2 1.3 1 1 0 1 1 1 1 NAD(P)H-binding WD40 PF00400.32 CCF40568.1 - 0.7 10.9 9.6 97 4.1 0.0 5.7 5 1 1 6 6 6 0 WD domain, G-beta repeat Pkinase PF00069.25 CCF40569.1 - 1.4e-36 126.3 0.0 1.7e-36 126.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF40569.1 - 7.9e-29 100.7 0.0 9.9e-29 100.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CCF40569.1 - 0.0011 17.8 0.0 0.0015 17.4 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 CCF40569.1 - 0.0062 15.9 0.0 0.0099 15.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 CCF40569.1 - 0.17 11.3 0.0 0.24 10.7 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 CCF40569.1 - 0.19 10.7 0.0 0.24 10.3 0.0 1.1 1 0 0 1 1 1 0 Haspin like kinase domain FAM176 PF14851.6 CCF40572.1 - 0.065 12.9 2.9 0.065 12.9 2.9 1.0 1 0 0 1 1 1 0 FAM176 family Ribosomal_L40e PF01020.17 CCF40574.1 - 3.7e-32 110.0 10.1 5.3e-32 109.5 10.1 1.2 1 0 0 1 1 1 1 Ribosomal L40e family Yip1 PF04893.17 CCF40575.1 - 8.1e-11 41.9 18.3 1.3e-10 41.3 18.3 1.4 1 1 0 1 1 1 1 Yip1 domain Rhodanese PF00581.20 CCF40576.1 - 1.7e-10 41.3 0.0 2.6e-10 40.8 0.0 1.2 1 0 0 1 1 1 1 Rhodanese-like domain CLPTM1 PF05602.12 CCF40577.1 - 2.1e-152 508.1 0.0 2.6e-152 507.8 0.0 1.1 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) DUF1772 PF08592.11 CCF40577.1 - 0.44 10.9 2.1 4.6 7.6 0.3 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF1772) MFS_1 PF07690.16 CCF40578.1 - 5.4e-15 55.2 32.8 1.6e-12 47.1 35.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily UNC-93 PF05978.16 CCF40578.1 - 1.3e-05 24.9 7.5 1.8e-05 24.5 6.0 2.1 2 0 0 2 2 2 1 Ion channel regulatory protein UNC-93 Sugar_tr PF00083.24 CCF40579.1 - 4.8e-103 345.4 19.7 5.6e-103 345.2 19.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF40579.1 - 2.4e-19 69.5 39.8 7.3e-16 58.0 13.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily AAA_16 PF13191.6 CCF40580.1 - 7.6e-06 26.4 2.2 1.6e-05 25.3 0.3 2.5 2 2 0 2 2 2 1 AAA ATPase domain ATPase_2 PF01637.18 CCF40580.1 - 0.0003 20.8 0.1 0.00073 19.5 0.1 1.6 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea DUF815 PF05673.13 CCF40580.1 - 0.024 13.8 0.0 0.049 12.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA PF00004.29 CCF40580.1 - 0.076 13.4 0.1 0.21 12.0 0.1 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ATPase PF06745.13 CCF40580.1 - 0.082 12.2 1.1 0.18 11.1 1.1 1.6 1 1 0 1 1 1 0 KaiC DUF632 PF04782.12 CCF40580.1 - 0.11 11.8 0.2 0.19 11.0 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF632) NTPase_1 PF03266.15 CCF40580.1 - 0.12 12.3 0.1 0.29 11.0 0.1 1.7 1 0 0 1 1 1 0 NTPase AAA_7 PF12775.7 CCF40580.1 - 0.13 11.7 0.0 0.26 10.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_29 PF13555.6 CCF40580.1 - 0.19 11.5 0.1 0.4 10.5 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain cobW PF02492.19 CCF40580.1 - 0.22 11.1 0.2 4.8 6.7 0.1 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain E1-E2_ATPase PF00122.20 CCF40581.1 - 4.3e-35 120.9 0.8 4.3e-35 120.9 0.8 2.1 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 CCF40581.1 - 7e-26 91.0 2.3 7e-26 91.0 2.3 2.9 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 CCF40581.1 - 7.4e-22 77.2 0.0 1.8e-21 76.0 0.0 1.7 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 CCF40581.1 - 2.7e-14 54.0 0.2 2.5e-13 50.8 0.2 2.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 CCF40581.1 - 3.5e-08 33.0 0.0 8.3e-08 31.8 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 CCF40581.1 - 6.5e-05 22.8 0.5 0.00064 19.5 0.8 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF202 PF02656.15 CCF40581.1 - 4.6 7.8 6.9 1.1 9.7 1.0 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF202) NACHT PF05729.12 CCF40582.1 - 8.8e-06 25.7 0.0 2e-05 24.6 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 CCF40582.1 - 4.2e-05 24.0 0.0 0.0001 22.7 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain KAP_NTPase PF07693.14 CCF40582.1 - 0.00076 18.8 0.1 0.015 14.6 0.0 2.2 2 0 0 2 2 2 1 KAP family P-loop domain AAA_22 PF13401.6 CCF40582.1 - 0.0058 16.9 0.0 0.018 15.3 0.0 1.9 1 0 0 1 1 1 1 AAA domain DUF1039 PF06287.11 CCF40582.1 - 0.0071 16.7 0.0 0.018 15.4 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1039) ABC_tran PF00005.27 CCF40582.1 - 0.026 15.0 0.0 0.072 13.6 0.0 1.8 1 0 0 1 1 1 0 ABC transporter AAA_30 PF13604.6 CCF40582.1 - 0.066 12.9 0.1 0.27 10.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 CCF40582.1 - 0.097 12.4 0.0 0.22 11.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 CCF40582.1 - 0.1 12.7 0.1 1.6 8.8 0.0 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA PF00004.29 CCF40582.1 - 0.11 13.0 0.0 0.43 11.0 0.0 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Phage_min_cap2 PF06152.11 CCF40582.1 - 0.13 11.1 0.0 0.26 10.2 0.0 1.4 1 0 0 1 1 1 0 Phage minor capsid protein 2 Fungal_trans PF04082.18 CCF40583.1 - 0.00016 20.8 0.0 0.00028 20.0 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Nup188_C PF18378.1 CCF40585.1 - 4.6e-150 499.6 0.0 7.2e-150 498.9 0.0 1.3 1 0 0 1 1 1 1 Nuclear pore protein NUP188 C-terminal domain Nup188 PF10487.9 CCF40585.1 - 4.5e-12 44.8 0.0 1.5e-11 43.0 0.0 1.8 1 1 0 1 1 1 1 Nucleoporin subcomplex protein binding to Pom34 SIP1 PF04938.12 CCF40585.1 - 0.19 11.4 0.0 0.6 9.8 0.0 1.8 2 0 0 2 2 2 0 Survival motor neuron (SMN) interacting protein 1 (SIP1) Antimicrobial15 PF08110.12 CCF40585.1 - 0.24 11.7 3.2 1.4 9.3 0.1 2.8 2 0 0 2 2 2 0 Ocellatin family Croc_4 PF17691.1 CCF40587.1 - 0.12 12.4 1.7 8.1 6.5 0.2 2.5 3 0 0 3 3 3 0 Contingent replication of cDNA 4 SnoaL_4 PF13577.6 CCF40588.1 - 7.8e-10 39.0 0.0 1.1e-09 38.5 0.0 1.2 1 0 0 1 1 1 1 SnoaL-like domain Ras PF00071.22 CCF40589.1 - 4.7e-56 188.9 0.0 5.4e-56 188.7 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCF40589.1 - 8.3e-22 77.7 0.0 1.2e-21 77.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCF40589.1 - 4.2e-07 29.6 0.0 6.8e-07 28.9 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 CCF40589.1 - 0.0011 18.4 0.0 0.0016 17.9 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit NB-ARC PF00931.22 CCF40589.1 - 0.056 12.6 0.1 0.53 9.4 0.0 2.0 1 1 1 2 2 2 0 NB-ARC domain Gtr1_RagA PF04670.12 CCF40589.1 - 0.17 11.2 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Skp1 PF01466.19 CCF40589.1 - 0.21 11.8 0.6 1.2 9.3 0.1 2.4 3 0 0 3 3 3 0 Skp1 family, dimerisation domain Glyco_hydro_47 PF01532.20 CCF40590.1 - 5.1e-163 543.2 0.0 5.8e-163 543.0 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Rrn6 PF10214.9 CCF40591.1 - 0.017 13.6 0.2 0.017 13.6 0.2 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor FYVE_2 PF02318.16 CCF40591.1 - 4.8 7.4 7.5 10 6.4 0.0 3.0 3 0 0 3 3 3 0 FYVE-type zinc finger ADH_zinc_N_2 PF13602.6 CCF40592.1 - 7.2e-10 40.0 0.1 7.5e-10 40.0 0.1 1.0 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Amino_oxidase PF01593.24 CCF40593.1 - 1.2e-17 64.3 0.0 1.9e-17 63.7 0.0 1.3 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase PALP PF00291.25 CCF40595.1 - 2.6e-20 73.0 0.1 2.6e-20 73.0 0.1 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Cation_efflux PF01545.21 CCF40596.1 - 2.7e-25 89.3 1.7 4.9e-16 59.1 0.0 2.1 2 0 0 2 2 2 2 Cation efflux family IML1 PF12257.8 CCF40597.1 - 8.7e-120 399.1 0.0 1.2e-119 398.7 0.0 1.2 1 0 0 1 1 1 1 Vacuolar membrane-associated protein Iml1 DEP PF00610.21 CCF40597.1 - 1.5e-26 92.2 0.2 3.2e-26 91.2 0.2 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Exo_endo_phos PF03372.23 CCF40598.1 - 1.2e-09 38.1 0.1 2.1e-09 37.3 0.1 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family BBS2_Mid PF14783.6 CCF40598.1 - 0.091 12.8 0.1 0.42 10.7 0.0 2.3 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region Mito_carr PF00153.27 CCF40599.1 - 2.9e-31 107.2 0.2 4.1e-22 77.9 0.1 2.0 2 0 0 2 2 2 2 Mitochondrial carrier protein Fungal_trans PF04082.18 CCF40600.1 - 9.5e-23 80.6 0.4 1.7e-22 79.8 0.4 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF40600.1 - 1.9e-09 37.5 8.2 4e-09 36.4 8.2 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RNA_pol_Rpb2_7 PF04560.20 CCF40600.1 - 0.091 13.2 0.0 0.22 11.9 0.0 1.6 1 0 0 1 1 1 0 RNA polymerase Rpb2, domain 7 ABC_membrane PF00664.23 CCF40601.1 - 1.5e-06 28.1 0.1 2.1e-06 27.6 0.1 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region Abhydrolase_6 PF12697.7 CCF40602.1 - 1.3e-18 68.4 1.1 1.5e-18 68.2 1.1 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCF40602.1 - 8.1e-06 25.3 0.0 0.0054 16.0 0.0 2.5 2 1 0 2 2 2 2 Serine aminopeptidase, S33 DUF900 PF05990.12 CCF40602.1 - 0.0019 17.8 0.0 0.0024 17.4 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) Abhydrolase_8 PF06259.12 CCF40602.1 - 0.0054 16.4 0.0 0.009 15.7 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase Abhydrolase_1 PF00561.20 CCF40602.1 - 0.0067 16.1 0.0 0.25 10.9 0.0 2.1 2 0 0 2 2 2 1 alpha/beta hydrolase fold PGAP1 PF07819.13 CCF40602.1 - 0.018 14.8 0.0 0.031 14.0 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Neisseria_TspB PF05616.13 CCF40604.1 - 1.6 7.2 8.0 2 6.8 8.0 1.1 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein IPT PF01745.16 CCF40605.1 - 0.036 13.5 0.0 0.95 8.8 0.1 2.1 2 0 0 2 2 2 0 Isopentenyl transferase NS3_envE PF02723.14 CCF40605.1 - 0.18 11.9 2.4 0.18 11.9 0.2 2.2 2 0 0 2 2 2 0 Non-structural protein NS3/Small envelope protein E Mem_trans PF03547.18 CCF40607.1 - 1.9e-22 79.2 4.3 5.2e-22 77.8 4.3 1.6 1 1 0 1 1 1 1 Membrane transport protein Peptidase_C14 PF00656.22 CCF40609.1 - 9.2e-40 137.1 0.0 1.2e-32 113.8 0.0 2.1 1 1 1 2 2 2 2 Caspase domain GST_N PF02798.20 CCF40610.1 - 1.8e-12 47.4 0.0 2.7e-12 46.8 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 CCF40610.1 - 8e-12 45.4 0.0 1.3e-11 44.7 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CCF40610.1 - 4.4e-10 39.6 0.0 7.2e-10 39.0 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CCF40610.1 - 3.2e-09 36.7 0.2 6.5e-09 35.7 0.2 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 CCF40610.1 - 3.5e-07 30.4 0.0 5.2e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 CCF40610.1 - 7e-06 26.2 0.0 1.2e-05 25.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain MBOAT PF03062.19 CCF40611.1 - 3.5e-16 59.5 1.2 3.5e-16 59.5 1.2 2.4 3 0 0 3 3 3 1 MBOAT, membrane-bound O-acyltransferase family SUZ PF12752.7 CCF40612.1 - 1.7e-15 57.5 4.9 1.7e-15 57.5 4.9 3.2 3 0 0 3 3 3 1 SUZ domain R3H PF01424.22 CCF40612.1 - 2.5e-08 33.8 0.1 5.8e-08 32.6 0.1 1.6 1 0 0 1 1 1 1 R3H domain Transferase PF02458.15 CCF40613.1 - 0.023 13.3 0.0 0.03 13.0 0.0 1.1 1 0 0 1 1 1 0 Transferase family DUF4531 PF15041.6 CCF40613.1 - 0.034 14.2 0.0 0.34 11.0 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4531) Fungal_trans PF04082.18 CCF40614.1 - 4.2e-15 55.5 0.0 6.7e-15 54.8 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Methyltransf_25 PF13649.6 CCF40615.1 - 3.1e-17 63.1 0.0 7.7e-17 61.8 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF40615.1 - 2.9e-12 47.1 0.0 7.3e-12 45.8 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF40615.1 - 9.2e-08 32.1 0.0 1.9e-07 31.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF40615.1 - 5.3e-07 29.5 0.0 1e-06 28.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF40615.1 - 5.9e-07 30.2 0.0 1.1e-06 29.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCF40615.1 - 9.8e-06 25.1 0.0 1.6e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_8 PF05148.15 CCF40615.1 - 0.064 13.1 0.0 0.1 12.4 0.0 1.2 1 0 0 1 1 1 0 Hypothetical methyltransferase FtsJ PF01728.19 CCF40615.1 - 0.071 13.2 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase DnaJ PF00226.31 CCF40616.1 - 6.9e-09 35.7 0.1 1.3e-08 34.8 0.1 1.5 1 0 0 1 1 1 1 DnaJ domain Zn_clus PF00172.18 CCF40617.1 - 1.7e-06 28.0 8.7 2.5e-06 27.5 8.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2043 PF09740.9 CCF40617.1 - 1.8 9.3 3.6 2.9 8.6 3.6 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2043) MFS_1 PF07690.16 CCF40618.1 - 4.8e-13 48.8 38.8 7.3e-13 48.2 38.8 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.16 CCF40618.1 - 4.6e-05 23.2 7.7 4.6e-05 23.2 7.7 2.6 2 2 0 2 2 2 1 Ion channel regulatory protein UNC-93 AIRS_C PF02769.22 CCF40619.1 - 7.3e-33 113.9 0.1 9e-33 113.6 0.1 1.1 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain AIRS PF00586.24 CCF40619.1 - 8.9e-10 39.1 0.4 8.9e-10 39.1 0.4 1.7 2 0 0 2 2 2 1 AIR synthase related protein, N-terminal domain RcsD_ABL PF16359.5 CCF40620.1 - 0.056 13.6 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 RcsD-ABL domain DUF4678 PF15727.5 CCF40621.1 - 0.0067 15.7 1.2 0.009 15.3 1.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4678) DUF2267 PF10025.9 CCF40621.1 - 0.044 14.1 0.1 0.099 12.9 0.1 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2267) IDO PF01231.18 CCF40622.1 - 1.3e-34 119.8 0.0 1.7e-34 119.4 0.0 1.1 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase MFS_1 PF07690.16 CCF40623.1 - 1.6e-39 135.8 36.3 1.6e-39 135.8 36.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily PTR2 PF00854.21 CCF40623.1 - 0.00055 18.9 5.5 0.025 13.4 2.3 2.3 1 1 1 2 2 2 2 POT family CxC4 PF18717.1 CCF40624.1 - 0.12 12.2 0.1 0.16 11.8 0.1 1.2 1 0 0 1 1 1 0 CxC4 like cysteine cluster associated with KDZ transposases Dicty_REP PF05086.12 CCF40625.1 - 0.045 11.7 8.9 0.068 11.1 8.9 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein FTHFS PF01268.19 CCF40626.1 - 2.1e-256 851.5 0.1 2.4e-256 851.3 0.1 1.0 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase GTP_EFTU PF00009.27 CCF40626.1 - 0.18 11.3 0.2 0.37 10.3 0.0 1.7 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain SNARE PF05739.19 CCF40627.1 - 5.1e-16 58.4 0.7 1e-15 57.4 0.7 1.5 1 0 0 1 1 1 1 SNARE domain Syntaxin PF00804.25 CCF40627.1 - 0.00027 20.7 10.7 0.002 17.8 10.7 2.0 1 1 0 1 1 1 1 Syntaxin MCPsignal PF00015.21 CCF40627.1 - 0.0067 16.3 7.2 0.22 11.3 0.9 2.6 3 0 0 3 3 3 2 Methyl-accepting chemotaxis protein (MCP) signalling domain GCP_C_terminal PF04130.13 CCF40627.1 - 0.04 13.4 0.3 0.14 11.6 0.0 1.8 2 0 0 2 2 2 0 Gamma tubulin complex component C-terminal DUF2207 PF09972.9 CCF40627.1 - 0.13 11.0 0.3 8.1 5.1 0.0 2.0 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) DNA_repr_REX1B PF14966.6 CCF40627.1 - 0.17 12.6 2.3 0.4 11.4 0.2 2.6 2 1 0 2 2 2 0 DNA repair REX1-B FeoB_associated PF12669.7 CCF40627.1 - 0.28 11.6 1.6 0.58 10.6 1.6 1.5 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein CALCOCO1 PF07888.11 CCF40627.1 - 1.1 8.1 6.8 2.3 7.0 0.6 2.1 2 0 0 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like SlyX PF04102.12 CCF40627.1 - 6.7 7.4 11.9 1.8 9.3 0.2 3.7 3 1 1 4 4 4 0 SlyX PPR_2 PF13041.6 CCF40628.1 - 0.011 15.9 0.1 0.18 12.0 0.0 2.6 2 0 0 2 2 2 0 PPR repeat family PPR_long PF17177.4 CCF40628.1 - 0.011 15.1 0.0 0.018 14.4 0.0 1.2 1 0 0 1 1 1 0 Pentacotripeptide-repeat region of PRORP COX7a PF02238.15 CCF40629.1 - 3.6e-22 78.5 0.3 4.3e-22 78.3 0.3 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VII Clathrin_lg_ch PF01086.17 CCF40630.1 - 6e-75 252.2 4.7 6.7e-75 252.1 4.7 1.0 1 0 0 1 1 1 1 Clathrin light chain CTD_bind PF04818.13 CCF40631.1 - 2e-17 63.7 0.2 6.4e-17 62.1 0.0 2.0 2 0 0 2 2 2 1 RNA polymerase II-binding domain. CREPT PF16566.5 CCF40631.1 - 0.0013 18.9 0.1 0.0041 17.3 0.1 1.8 1 0 0 1 1 1 1 Cell-cycle alteration and expression-elevated protein in tumour CTK3 PF12243.8 CCF40631.1 - 0.1 12.6 0.1 0.28 11.2 0.1 1.7 2 0 0 2 2 2 0 CTD kinase subunit gamma CTK3 ABC_tran_CTD PF16326.5 CCF40631.1 - 0.1 12.8 7.9 1.9 8.8 6.4 2.8 2 1 0 2 2 2 0 ABC transporter C-terminal domain ABC_membrane PF00664.23 CCF40632.1 - 6.1e-50 170.4 6.0 7.5e-50 170.1 6.0 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 CCF40632.1 - 0.0024 18.4 0.4 0.0054 17.2 0.0 1.8 2 0 0 2 2 2 1 ABC transporter ABC_tran PF00005.27 CCF40634.1 - 8.9e-19 68.4 0.0 1.7e-18 67.5 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CCF40634.1 - 1.4e-05 25.0 0.1 0.031 14.1 0.2 2.4 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CCF40634.1 - 4.5e-05 23.0 0.1 0.078 12.4 0.0 2.2 1 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 CCF40634.1 - 0.0008 19.7 0.2 0.0024 18.2 0.2 1.8 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CCF40634.1 - 0.0046 16.7 0.4 0.015 15.1 0.4 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 CCF40634.1 - 0.0079 16.6 0.1 0.021 15.2 0.1 1.7 1 0 0 1 1 1 1 AAA ATPase domain T2SSE PF00437.20 CCF40634.1 - 0.022 13.9 0.1 0.037 13.1 0.1 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_23 PF13476.6 CCF40634.1 - 0.025 15.1 0.3 0.045 14.3 0.3 1.3 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 CCF40634.1 - 0.026 14.2 0.1 0.055 13.2 0.1 1.5 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 CCF40634.1 - 0.04 13.9 0.1 0.081 12.9 0.1 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE cobW PF02492.19 CCF40634.1 - 0.043 13.4 1.0 0.072 12.7 1.0 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain MMR_HSR1 PF01926.23 CCF40634.1 - 0.084 13.0 0.1 0.17 12.0 0.1 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase ABC_membrane PF00664.23 CCF40634.1 - 0.092 12.4 8.3 0.066 12.9 0.8 2.3 2 0 0 2 2 2 0 ABC transporter transmembrane region AAA_33 PF13671.6 CCF40634.1 - 0.094 12.9 0.1 0.17 12.0 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 CCF40634.1 - 0.098 13.0 0.0 0.2 12.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 CCF40634.1 - 0.1 12.5 0.3 0.19 11.6 0.3 1.3 1 0 0 1 1 1 0 RsgA GTPase AAA_11 PF13086.6 CCF40634.1 - 0.11 12.2 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain TrwB_AAD_bind PF10412.9 CCF40634.1 - 0.12 11.3 0.4 0.25 10.2 0.4 1.5 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_7 PF12775.7 CCF40634.1 - 0.14 11.6 0.1 0.29 10.6 0.1 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region MobB PF03205.14 CCF40634.1 - 0.15 12.0 0.3 0.28 11.1 0.3 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B NACHT PF05729.12 CCF40634.1 - 0.18 11.7 0.2 0.34 10.8 0.2 1.4 1 0 0 1 1 1 0 NACHT domain NTPase_1 PF03266.15 CCF40634.1 - 0.38 10.7 1.4 1.3 8.9 0.2 2.1 2 0 0 2 2 2 0 NTPase GST_C_2 PF13410.6 CCF40635.1 - 1.9e-07 31.0 0.0 3.4e-07 30.2 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 CCF40635.1 - 3.6e-07 30.4 0.0 6.9e-07 29.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 CCF40635.1 - 4e-07 30.3 0.0 9e-07 29.2 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 CCF40635.1 - 2.4e-05 24.4 0.0 5.1e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 CCF40635.1 - 0.00021 21.5 0.0 0.00041 20.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CCF40635.1 - 0.00084 19.5 0.0 0.0015 18.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 CCF40635.1 - 0.07 13.7 0.0 0.13 12.8 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain NDUF_B4 PF07225.12 CCF40636.1 - 0.0017 18.2 0.0 0.0018 18.2 0.0 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4) AA_permease_2 PF13520.6 CCF40638.1 - 1.8e-31 109.4 17.2 1.8e-31 109.4 17.2 1.3 1 1 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CCF40638.1 - 7.9e-06 24.7 12.6 1.1e-05 24.3 12.6 1.1 1 0 0 1 1 1 1 Amino acid permease Fun_ATP-synt_8 PF05933.13 CCF40638.1 - 0.046 13.9 1.7 0.16 12.2 1.7 1.9 1 0 0 1 1 1 0 Fungal ATP synthase protein 8 (A6L) Vpu PF00558.19 CCF40638.1 - 3.7 7.4 6.7 0.3 10.9 1.8 1.7 2 0 0 2 2 2 0 Vpu protein DUF4381 PF14316.6 CCF40638.1 - 6.2 7.0 6.7 4.1 7.6 2.9 2.5 1 1 0 2 2 2 0 Domain of unknown function (DUF4381) CN_hydrolase PF00795.22 CCF40640.1 - 1.5e-37 129.4 0.0 1.9e-37 129.0 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase FMN_red PF03358.15 CCF40644.1 - 0.0018 18.1 0.0 0.0024 17.6 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase ApbA PF02558.16 CCF40646.1 - 3.2e-07 30.1 0.0 3.3e-07 30.1 0.0 1.0 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ThiF PF00899.21 CCF40646.1 - 0.0036 16.7 0.5 0.0043 16.4 0.5 1.1 1 0 0 1 1 1 1 ThiF family FAD_binding_3 PF01494.19 CCF40646.1 - 0.18 11.0 0.1 0.18 11.0 0.1 1.0 1 0 0 1 1 1 0 FAD binding domain DAO PF01266.24 CCF40646.1 - 0.64 9.5 3.2 0.69 9.4 3.2 1.2 1 1 0 1 1 1 0 FAD dependent oxidoreductase DUF2470 PF10615.9 CCF40647.1 - 1.6e-22 79.9 0.0 2.2e-22 79.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2470) Glyco_hydro_12 PF01670.16 CCF40648.1 - 2.5e-31 109.4 9.0 2.9e-31 109.1 9.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 12 PPV_E2_C PF00511.17 CCF40648.1 - 4.9 7.4 7.5 27 5.0 3.1 2.4 1 1 1 2 2 2 0 E2 (early) protein, C terminal Methyltransf_23 PF13489.6 CCF40649.1 - 2e-19 70.0 0.0 3e-19 69.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF40649.1 - 1.1e-11 45.3 0.0 2.8e-11 44.0 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF40649.1 - 4.6e-08 33.0 0.0 4.6e-07 29.8 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF40649.1 - 2.9e-07 31.0 0.0 5.8e-07 30.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF40649.1 - 7.5e-06 26.6 0.0 6.2e-05 23.7 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CCF40649.1 - 0.00012 21.6 0.0 0.00075 19.1 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase small domain FtsJ PF01728.19 CCF40649.1 - 0.0026 17.9 0.0 0.035 14.2 0.0 2.2 2 1 0 2 2 2 1 FtsJ-like methyltransferase PrmA PF06325.13 CCF40649.1 - 0.0029 17.0 0.0 0.0045 16.4 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Ubie_methyltran PF01209.18 CCF40649.1 - 0.023 14.0 0.0 0.28 10.5 0.0 2.1 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family Methyltransf_16 PF10294.9 CCF40649.1 - 0.036 13.8 0.0 0.058 13.1 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_4 PF02390.17 CCF40649.1 - 0.042 13.3 0.0 0.1 12.1 0.0 1.6 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_23 PF13489.6 CCF40651.1 - 1.2e-22 80.5 0.0 1.8e-22 79.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF40651.1 - 8.8e-13 48.8 0.0 2.1e-12 47.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF40651.1 - 2.9e-10 40.7 0.0 5.2e-10 39.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF40651.1 - 4.3e-10 39.6 0.0 2.6e-09 37.0 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF40651.1 - 5.2e-08 33.5 0.0 3.3e-07 31.0 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 CCF40651.1 - 0.0007 19.1 0.0 0.0012 18.3 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 CCF40651.1 - 0.001 18.7 0.0 0.0018 17.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain GidB PF02527.15 CCF40651.1 - 0.084 12.2 0.0 0.42 9.9 0.0 1.9 1 1 0 1 1 1 0 rRNA small subunit methyltransferase G Ubie_methyltran PF01209.18 CCF40651.1 - 0.11 11.8 0.0 0.76 9.1 0.0 2.0 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family PCMT PF01135.19 CCF40651.1 - 0.15 11.8 0.0 0.33 10.7 0.0 1.6 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) LRR_adjacent PF08191.11 CCF40651.1 - 0.16 12.2 0.1 0.29 11.3 0.1 1.4 1 0 0 1 1 1 0 LRR adjacent Cornifin PF02389.15 CCF40652.1 - 0.16 12.2 0.0 0.29 11.3 0.0 1.3 1 0 0 1 1 1 0 Cornifin (SPRR) family Herpes_UL56 PF04534.12 CCF40654.1 - 0.15 11.5 3.2 0.24 10.9 0.4 1.9 1 1 0 2 2 2 0 Herpesvirus UL56 protein UME PF08064.13 CCF40655.1 - 9.6e-36 121.8 0.1 1.1e-34 118.4 0.0 2.9 2 0 0 2 2 2 1 UME (NUC010) domain MFS_1 PF07690.16 CCF40656.1 - 7.3e-34 117.2 26.3 7.3e-34 117.2 26.3 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily Methyltrans_SAM PF10672.9 CCF40656.1 - 0.13 11.4 0.0 0.21 10.7 0.0 1.2 1 0 0 1 1 1 0 S-adenosylmethionine-dependent methyltransferase FMN_dh PF01070.18 CCF40657.1 - 2.7e-111 371.9 0.0 3.8e-111 371.5 0.0 1.2 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 CCF40657.1 - 1.1e-17 64.0 0.0 2.1e-17 63.0 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.17 CCF40657.1 - 1.6e-07 30.8 0.0 2.3e-07 30.3 0.0 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase NMO PF03060.15 CCF40657.1 - 8.1e-05 22.2 0.3 0.00012 21.6 0.3 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 CCF40657.1 - 0.00011 21.3 0.1 0.00021 20.4 0.1 1.4 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain ThiG PF05690.14 CCF40657.1 - 0.0019 17.5 0.1 0.67 9.2 0.0 2.2 2 0 0 2 2 2 2 Thiazole biosynthesis protein ThiG His_biosynth PF00977.21 CCF40657.1 - 0.051 13.0 0.1 0.53 9.7 0.0 2.2 2 0 0 2 2 2 0 Histidine biosynthesis protein Trp_DMAT PF11991.8 CCF40659.1 - 2e-59 201.9 0.0 2.2e-59 201.7 0.0 1.0 1 0 0 1 1 1 1 Tryptophan dimethylallyltransferase DUF3531 PF12049.8 CCF40659.1 - 0.097 12.6 0.0 0.13 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3531) FAD_binding_4 PF01565.23 CCF40660.1 - 8.2e-25 87.2 0.1 1.6e-24 86.2 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain TrkA_C PF02080.21 CCF40660.1 - 0.092 12.6 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 TrkA-C domain mRNA_triPase PF02940.15 CCF40661.1 - 3.1e-56 190.5 0.0 4.3e-56 190.1 0.0 1.2 1 0 0 1 1 1 1 mRNA capping enzyme, beta chain Xan_ur_permease PF00860.20 CCF40662.1 - 2.3e-30 105.6 9.8 3.4e-30 105.0 9.8 1.2 1 0 0 1 1 1 1 Permease family Pec_lyase_C PF00544.19 CCF40663.1 - 1.6e-17 63.8 7.5 1.1e-15 57.8 7.5 2.3 1 1 0 1 1 1 1 Pectate lyase Pas_Saposin PF09016.10 CCF40664.1 - 0.1 12.9 0.1 0.57 10.6 0.1 2.0 1 1 1 2 2 2 0 Pas factor saposin fold AlaDh_PNT_C PF01262.21 CCF40667.1 - 1.9e-05 24.1 0.0 0.00018 20.9 0.0 2.0 1 1 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Cmc1 PF08583.10 CCF40668.1 - 9.9e-17 60.7 0.8 9.9e-17 60.7 0.8 2.0 3 0 0 3 3 3 1 Cytochrome c oxidase biogenesis protein Cmc1 like CHCH PF06747.13 CCF40668.1 - 0.011 15.8 0.3 6.5 7.0 0.0 2.3 2 0 0 2 2 2 0 CHCH domain CX9C PF16860.5 CCF40668.1 - 0.081 12.9 0.2 0.19 11.8 0.2 1.6 1 1 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, DUF3128 PF11326.8 CCF40668.1 - 0.084 13.2 8.0 6.4 7.2 8.0 2.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3128) fn3 PF00041.21 CCF40669.1 - 4.5e-08 33.3 0.0 1.3e-07 31.8 0.0 1.8 1 0 0 1 1 1 1 Fibronectin type III domain DUF3584 PF12128.8 CCF40669.1 - 8.6 3.7 43.8 14 3.1 43.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) UDPGP PF01704.18 CCF40670.1 - 8.7e-56 189.3 0.0 1.1e-55 189.0 0.0 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase NTP_transf_3 PF12804.7 CCF40670.1 - 0.091 13.1 0.0 0.21 11.9 0.0 1.6 1 0 0 1 1 1 0 MobA-like NTP transferase domain MFS_1 PF07690.16 CCF40671.1 - 2.2e-34 119.0 38.5 2.2e-34 119.0 38.5 1.7 1 1 2 3 3 3 1 Major Facilitator Superfamily Vma12 PF11712.8 CCF40671.1 - 0.17 12.0 0.9 1.3 9.1 0.2 2.5 2 0 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Pam17 PF08566.10 CCF40671.1 - 0.38 10.6 1.8 2.7 7.8 0.1 2.7 2 0 0 2 2 2 0 Mitochondrial import protein Pam17 ADH_zinc_N PF00107.26 CCF40672.1 - 1.9e-11 44.0 0.1 4.5e-11 42.8 0.1 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCF40672.1 - 0.00026 20.8 0.1 0.00067 19.5 0.1 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 CCF40672.1 - 0.00069 20.7 0.0 0.0018 19.3 0.0 1.8 1 1 0 1 1 1 1 Zinc-binding dehydrogenase Exo70 PF03081.15 CCF40674.1 - 1.6e-19 70.3 0.2 1.1e-18 67.5 0.0 2.3 2 1 1 3 3 3 1 Exo70 exocyst complex subunit Baculo_PEP_C PF04513.12 CCF40674.1 - 0.053 13.6 5.1 16 5.5 0.1 3.6 4 0 0 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF2203 PF09969.9 CCF40674.1 - 0.12 13.1 2.5 0.26 12.0 0.2 2.4 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2203) MukF_M PF17192.4 CCF40674.1 - 0.28 10.9 2.3 8.3 6.1 0.1 2.6 3 0 0 3 3 3 0 MukF middle domain Aminotran_3 PF00202.21 CCF40675.1 - 5.5e-83 278.9 0.0 6.7e-83 278.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 CCF40675.1 - 0.033 13.3 0.0 0.11 11.6 0.0 1.8 2 0 0 2 2 2 0 Aminotransferase class I and II PHY PF00360.20 CCF40676.1 - 1.4e-29 102.7 0.0 3.7e-29 101.3 0.0 1.6 2 0 0 2 2 2 1 Phytochrome region HATPase_c PF02518.26 CCF40676.1 - 3.2e-19 69.5 0.2 6e-19 68.6 0.2 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase GAF PF01590.26 CCF40676.1 - 4e-14 53.4 0.0 1.5e-13 51.5 0.0 2.1 1 0 0 1 1 1 1 GAF domain HisKA PF00512.25 CCF40676.1 - 1.3e-12 47.6 0.7 4.8e-12 45.7 0.7 2.0 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_2 PF08446.11 CCF40676.1 - 6.7e-08 33.2 0.0 2.2e-07 31.5 0.0 1.9 2 0 0 2 2 2 1 PAS fold HATPase_c_3 PF13589.6 CCF40676.1 - 0.019 14.8 0.1 0.044 13.6 0.1 1.6 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Cornifin PF02389.15 CCF40676.1 - 0.13 12.5 0.2 0.33 11.1 0.2 1.7 1 0 0 1 1 1 0 Cornifin (SPRR) family ECH_1 PF00378.20 CCF40677.1 - 1.7e-40 138.9 0.0 3e-40 138.1 0.0 1.2 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CCF40677.1 - 1.4e-31 110.3 0.0 3.5e-28 99.1 0.0 2.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase Tfb5 PF06331.12 CCF40678.1 - 1.7e-27 95.2 0.8 1.8e-27 95.1 0.8 1.0 1 0 0 1 1 1 1 Transcription factor TFIIH complex subunit Tfb5 TENA_THI-4 PF03070.16 CCF40679.1 - 8e-44 150.0 0.2 1e-40 139.8 0.1 2.0 1 1 1 2 2 2 2 TENA/THI-4/PQQC family Kazal_3 PF18434.1 CCF40680.1 - 0.019 14.7 0.5 0.028 14.1 0.5 1.3 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain DEAD PF00270.29 CCF40681.1 - 6.7e-50 169.3 0.0 4.5e-49 166.6 0.0 1.9 1 1 1 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 CCF40681.1 - 2e-05 24.7 0.0 0.00018 21.5 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 CCF40681.1 - 0.00039 20.8 0.0 0.0013 19.0 0.0 1.9 3 0 0 3 3 3 1 Helicase conserved C-terminal domain AAA_19 PF13245.6 CCF40681.1 - 0.019 15.3 0.0 6.4 7.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain DUF5335 PF17269.2 CCF40681.1 - 0.12 12.2 0.1 0.21 11.5 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5335) AAA_22 PF13401.6 CCF40681.1 - 0.3 11.3 0.9 29 4.9 0.0 3.0 3 0 0 3 3 3 0 AAA domain Zn_clus PF00172.18 CCF40682.1 - 0.0032 17.5 10.9 0.0044 17.1 10.9 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RTBV_P12 PF06361.11 CCF40682.1 - 0.018 15.4 0.5 0.03 14.7 0.2 1.5 2 0 0 2 2 2 0 Rice tungro bacilliform virus P12 protein Aminotran_1_2 PF00155.21 CCF40683.1 - 4.7e-81 272.8 0.0 5.9e-81 272.4 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 CCF40683.1 - 4.4e-05 22.2 0.0 7e-05 21.5 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 CCF40683.1 - 0.00052 19.1 0.1 0.0013 17.8 0.0 1.6 2 0 0 2 2 2 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 CCF40683.1 - 0.021 14.1 0.5 0.038 13.3 0.5 1.3 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family MFS_1 PF07690.16 CCF40684.1 - 7.5e-13 48.1 31.7 7.5e-13 48.1 31.7 1.5 1 1 1 2 2 2 1 Major Facilitator Superfamily UNC-93 PF05978.16 CCF40684.1 - 0.0007 19.3 5.2 0.0007 19.3 5.2 2.1 2 0 0 2 2 2 1 Ion channel regulatory protein UNC-93 Tyrosinase PF00264.20 CCF40685.1 - 9e-40 137.3 0.0 1.1e-39 137.0 0.0 1.1 1 0 0 1 1 1 1 Common central domain of tyrosinase GPI-anchored PF10342.9 CCF40686.1 - 4.7e-18 65.7 3.2 4.7e-18 65.7 3.2 2.9 2 1 1 3 3 3 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family MG2 PF01835.19 CCF40686.1 - 0.056 13.9 0.9 0.12 12.8 0.1 1.9 1 1 1 2 2 2 0 MG2 domain Srg PF02118.21 CCF40686.1 - 0.063 12.9 2.2 0.089 12.4 2.2 1.2 1 0 0 1 1 1 0 Srg family chemoreceptor RIFIN PF02009.16 CCF40686.1 - 0.49 10.2 3.2 0.55 10.1 3.2 1.1 1 0 0 1 1 1 0 Rifin Macoilin PF09726.9 CCF40686.1 - 2.3 6.7 7.1 2.2 6.7 7.1 1.0 1 0 0 1 1 1 0 Macoilin family Stevor PF17410.2 CCF40686.1 - 5.5 6.4 5.6 6.6 6.2 5.6 1.1 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame FSA_C PF10479.9 CCF40686.1 - 5.7 4.9 23.5 6.6 4.7 23.5 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Methyltransf_16 PF10294.9 CCF40687.1 - 0.19 11.4 0.0 0.56 9.9 0.0 1.6 2 0 0 2 2 2 0 Lysine methyltransferase NAD_binding_8 PF13450.6 CCF40688.1 - 1.7e-09 37.7 0.0 5.7e-09 36.1 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FMO-like PF00743.19 CCF40688.1 - 3.1e-06 25.9 0.1 2.5e-05 22.9 0.1 2.3 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like NAD_binding_9 PF13454.6 CCF40688.1 - 0.00083 19.4 0.1 0.037 14.0 0.0 2.9 3 0 0 3 3 3 1 FAD-NAD(P)-binding K_oxygenase PF13434.6 CCF40688.1 - 0.002 17.3 0.0 0.37 9.9 0.0 3.1 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 CCF40688.1 - 0.029 13.6 0.0 0.44 9.7 0.1 2.5 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Peptidase_M18 PF02127.15 CCF40689.1 - 1.8e-123 412.5 0.0 2.1e-123 412.3 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) DUF908 PF06012.12 CCF40691.1 - 0.022 14.2 0.3 0.046 13.1 0.2 1.5 1 1 1 2 2 2 0 Domain of Unknown Function (DUF908) Mo25 PF08569.11 CCF40691.1 - 0.086 12.2 0.0 0.092 12.1 0.0 1.0 1 0 0 1 1 1 0 Mo25-like HET PF06985.11 CCF40692.1 - 9.1e-28 97.4 0.0 1.5e-27 96.7 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) p450 PF00067.22 CCF40693.1 - 3.6e-14 52.4 0.0 5.4e-13 48.5 0.0 2.0 2 0 0 2 2 2 2 Cytochrome P450 DUF2481 PF10654.9 CCF40694.1 - 0.074 13.0 0.1 0.11 12.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2481) DUF1275 PF06912.11 CCF40695.1 - 6.6e-48 163.2 16.1 8e-48 162.9 16.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1275) adh_short PF00106.25 CCF40696.1 - 9.5e-17 61.1 0.0 1.2e-16 60.7 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF40696.1 - 3.4e-11 43.1 0.0 4.4e-11 42.8 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF40696.1 - 0.11 12.4 0.0 0.47 10.4 0.0 2.0 1 1 0 1 1 1 0 KR domain Sds3 PF08598.11 CCF40697.1 - 3e-23 83.0 3.6 3.9e-23 82.6 3.6 1.1 1 0 0 1 1 1 1 Sds3-like COG5 PF10392.9 CCF40698.1 - 1.8e-05 24.9 2.0 0.00037 20.7 0.2 2.9 3 0 0 3 3 3 1 Golgi transport complex subunit 5 COG7 PF10191.9 CCF40698.1 - 0.021 13.1 0.0 0.048 11.9 0.0 1.5 1 0 0 1 1 1 0 Golgi complex component 7 (COG7) DUF4795 PF16043.5 CCF40698.1 - 0.19 11.3 4.0 0.11 12.1 0.8 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) BEX PF04538.12 CCF40698.1 - 0.84 10.2 4.4 0.94 10.1 0.5 2.5 1 1 1 2 2 2 0 Brain expressed X-linked like family SLAC1 PF03595.17 CCF40699.1 - 4.1e-12 46.0 9.9 4.5e-12 45.9 9.9 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel DUF4293 PF14126.6 CCF40699.1 - 0.11 12.8 2.5 0.12 12.6 2.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4293) Corona_M PF01635.18 CCF40699.1 - 0.3 10.4 7.4 1.6 8.0 2.2 2.0 1 1 1 2 2 2 0 Coronavirus M matrix/glycoprotein PI3Ka PF00613.20 CCF40701.1 - 5.5e-59 198.7 1.2 8.6e-59 198.0 1.2 1.3 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 CCF40701.1 - 9.9e-47 159.8 0.0 1e-30 107.4 0.0 3.0 2 1 1 3 3 3 2 Phosphatidylinositol 3- and 4-kinase PI3K_C2 PF00792.24 CCF40701.1 - 0.0073 16.2 0.0 0.016 15.1 0.0 1.6 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 Condensation PF00668.20 CCF40703.1 - 1.8e-66 224.7 0.0 2.4e-66 224.3 0.0 1.1 1 0 0 1 1 1 1 Condensation domain AMP-binding PF00501.28 CCF40703.1 - 7.4e-62 209.3 0.0 1e-61 208.8 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.25 CCF40703.1 - 4e-09 36.7 0.4 8.9e-09 35.6 0.4 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site AMP-binding_C PF13193.6 CCF40703.1 - 0.14 13.1 0.0 0.28 12.2 0.0 1.5 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain ENTH PF01417.20 CCF40704.1 - 7.8e-46 155.2 0.1 1.1e-45 154.7 0.1 1.3 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.16 CCF40704.1 - 0.00032 19.8 0.0 0.00044 19.3 0.0 1.1 1 0 0 1 1 1 1 ANTH domain Brix PF04427.18 CCF40706.1 - 3.5e-33 115.3 0.1 4.7e-33 114.9 0.1 1.2 1 0 0 1 1 1 1 Brix domain Syntaxin PF00804.25 CCF40707.1 - 2.4e-27 95.9 10.8 2.4e-27 95.9 10.8 1.7 2 0 0 2 2 2 1 Syntaxin SNARE PF05739.19 CCF40707.1 - 2.7e-11 43.3 0.5 7.1e-11 41.9 0.5 1.8 1 0 0 1 1 1 1 SNARE domain Syntaxin_2 PF14523.6 CCF40707.1 - 7.5e-05 23.0 6.6 7.5e-05 23.0 6.6 2.4 2 1 0 2 2 2 1 Syntaxin-like protein DUF2207 PF09972.9 CCF40707.1 - 0.026 13.3 2.1 0.076 11.8 0.1 2.0 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Fib_alpha PF08702.10 CCF40707.1 - 0.028 14.6 12.4 0.17 12.1 3.4 2.2 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF3094 PF11293.8 CCF40707.1 - 0.031 14.0 0.1 0.094 12.4 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3094) TMCO5 PF14992.6 CCF40707.1 - 0.06 12.9 12.4 2.7 7.5 12.4 2.8 1 1 0 1 1 1 0 TMCO5 family FUSC PF04632.12 CCF40707.1 - 0.072 11.6 13.7 0.053 12.1 4.5 2.1 2 0 0 2 2 2 0 Fusaric acid resistance protein family SQS_PSY PF00494.19 CCF40707.1 - 0.1 12.0 4.8 0.18 11.3 0.8 2.2 2 0 0 2 2 2 0 Squalene/phytoene synthase DUF4094 PF13334.6 CCF40707.1 - 0.44 11.0 7.5 1.2 9.6 0.1 3.7 2 2 1 3 3 3 0 Domain of unknown function (DUF4094) PBP1_TM PF14812.6 CCF40707.1 - 0.5 10.8 0.0 0.5 10.8 0.0 2.3 3 0 0 3 3 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Tup_N PF08581.10 CCF40707.1 - 0.54 10.6 6.8 3 8.2 0.2 3.5 3 0 0 3 3 3 0 Tup N-terminal MCU PF04678.13 CCF40707.1 - 0.55 10.3 12.5 0.048 13.8 3.3 2.4 1 1 0 2 2 2 0 Mitochondrial calcium uniporter SLATT_5 PF18160.1 CCF40707.1 - 0.69 9.2 4.0 2.8 7.2 0.0 2.9 3 0 0 3 3 3 0 SMODS and SLOG-associating 2TM effector domain family 5 Use1 PF09753.9 CCF40707.1 - 0.7 9.6 17.0 6.9 6.3 17.0 2.0 1 1 0 1 1 1 0 Membrane fusion protein Use1 Tweety PF04906.13 CCF40707.1 - 3.9 6.0 8.5 0.36 9.4 2.3 2.2 1 1 2 3 3 3 0 Tweety SKA1 PF07160.12 CCF40707.1 - 4.4 7.1 15.2 0.32 10.8 3.8 2.5 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 1 Allexi_40kDa PF05549.11 CCF40707.1 - 5.3 6.5 9.4 1.5 8.3 2.5 2.2 2 0 0 2 2 2 0 Allexivirus 40kDa protein JIP_LZII PF16471.5 CCF40707.1 - 8.4 6.7 11.0 26 5.1 0.1 4.1 4 1 1 5 5 5 0 JNK-interacting protein leucine zipper II TPR_1 PF00515.28 CCF40708.1 - 5.9e-47 155.7 19.3 3.3e-06 26.7 0.0 11.5 11 0 0 11 11 11 10 Tetratricopeptide repeat TPR_2 PF07719.17 CCF40708.1 - 6.8e-43 141.4 14.6 0.00014 21.7 0.0 11.4 11 0 0 11 11 11 9 Tetratricopeptide repeat TPR_11 PF13414.6 CCF40708.1 - 1.6e-26 91.7 12.9 2e-05 24.2 0.0 8.6 5 2 3 8 8 8 6 TPR repeat TPR_17 PF13431.6 CCF40708.1 - 1.5e-23 81.4 7.1 7e-05 22.9 0.0 9.2 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_8 PF13181.6 CCF40708.1 - 3.3e-23 79.9 21.4 0.0045 17.1 0.0 11.2 11 0 0 11 11 11 6 Tetratricopeptide repeat TPR_16 PF13432.6 CCF40708.1 - 4.8e-22 78.3 9.8 0.0015 19.2 0.0 7.7 6 2 3 9 9 8 5 Tetratricopeptide repeat TPR_12 PF13424.6 CCF40708.1 - 1.3e-20 73.4 21.3 0.0036 17.6 0.4 9.3 3 3 6 9 9 9 7 Tetratricopeptide repeat TPR_19 PF14559.6 CCF40708.1 - 6.6e-15 55.4 14.8 4.9e-05 23.8 1.1 7.3 5 1 2 7 7 7 3 Tetratricopeptide repeat TPR_9 PF13371.6 CCF40708.1 - 3.5e-13 49.5 4.9 1.9e-05 24.7 0.0 5.8 5 2 2 7 7 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 CCF40708.1 - 4.3e-11 42.7 19.3 0.041 14.7 0.6 9.7 4 3 8 12 12 11 2 Tetratricopeptide repeat TPR_7 PF13176.6 CCF40708.1 - 1.5e-10 40.3 15.1 0.035 14.1 0.1 8.9 9 0 0 9 9 9 2 Tetratricopeptide repeat SHNi-TPR PF10516.9 CCF40708.1 - 9.3e-09 34.6 1.8 0.23 11.0 0.0 5.4 5 0 0 5 5 5 2 SHNi-TPR ANAPC3 PF12895.7 CCF40708.1 - 4.1e-08 33.3 11.2 0.31 11.3 0.0 6.1 2 2 3 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_MalT PF17874.1 CCF40708.1 - 1e-07 31.7 0.4 4.3e-07 29.6 0.3 2.0 1 1 0 2 2 2 1 MalT-like TPR region TPR_10 PF13374.6 CCF40708.1 - 3e-07 30.1 14.1 0.086 12.7 0.3 8.2 9 0 0 9 9 8 1 Tetratricopeptide repeat MAS20 PF02064.15 CCF40708.1 - 8.2e-05 22.7 9.8 0.00093 19.3 1.0 4.2 4 1 1 5 5 4 1 MAS20 protein import receptor TPR_6 PF13174.6 CCF40708.1 - 0.00017 22.0 18.4 13 6.7 0.0 8.8 10 0 0 10 10 9 0 Tetratricopeptide repeat MIT PF04212.18 CCF40708.1 - 0.0067 16.5 9.6 15 5.7 0.1 5.9 6 0 0 6 6 6 0 MIT (microtubule interacting and transport) domain DUF3856 PF12968.7 CCF40708.1 - 0.029 14.5 5.3 8.2 6.5 0.0 5.5 4 2 2 6 6 6 0 Domain of Unknown Function (DUF3856) TAF1_subA PF14929.6 CCF40708.1 - 0.056 12.9 1.6 0.2 11.0 0.1 2.3 2 1 1 3 3 3 0 TAF RNA Polymerase I subunit A HrpB1_HrpK PF09613.10 CCF40708.1 - 0.079 12.6 0.2 0.49 10.0 0.2 2.2 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB1_HrpK) Sel1 PF08238.12 CCF40708.1 - 0.2 12.4 7.0 11 6.9 0.1 4.7 5 0 0 5 5 4 0 Sel1 repeat TPR_20 PF14561.6 CCF40708.1 - 0.24 11.8 5.4 3.5 8.0 0.1 4.6 4 1 0 5 5 5 0 Tetratricopeptide repeat TPR_3 PF07720.12 CCF40708.1 - 1.4 9.0 15.0 0.57 10.2 0.3 5.5 6 0 0 6 6 6 0 Tetratricopeptide repeat Aminotran_4 PF01063.19 CCF40709.1 - 5e-16 59.3 0.0 9.6e-16 58.3 0.0 1.4 1 1 0 1 1 1 1 Amino-transferase class IV zf-C4pol PF14260.6 CCF40710.1 - 3.4e-05 24.2 0.3 5.1e-05 23.6 0.1 1.4 2 0 0 2 2 2 1 C4-type zinc-finger of DNA polymerase delta MMM1 PF10296.9 CCF40711.1 - 3.8e-07 29.5 0.4 2.2e-06 27.0 0.0 2.0 2 1 0 2 2 2 1 Maintenance of mitochondrial morphology protein 1 CbeA_antitoxin PF06154.11 CCF40712.1 - 0.17 12.5 0.0 0.21 12.2 0.0 1.1 1 0 0 1 1 1 0 CbeA_antitoxin, type IV, cytoskeleton bundling-enhancing factor A ADH_N PF08240.12 CCF40713.1 - 9.5e-24 83.4 1.2 1.8e-23 82.5 1.2 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCF40713.1 - 3.1e-18 66.0 0.0 5.8e-18 65.1 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 CCF40713.1 - 0.00011 22.0 0.0 0.00024 20.9 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase YAcAr PF10686.9 CCF40713.1 - 0.014 15.3 0.0 0.026 14.5 0.0 1.4 1 0 0 1 1 1 0 YspA, cpYpsA-related SLOG family MFS_1 PF07690.16 CCF40714.1 - 9.6e-49 166.2 58.8 6.1e-47 160.3 58.5 2.8 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 CCF40714.1 - 1e-18 67.1 14.1 1.5e-18 66.6 14.1 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 CCF40714.1 - 2e-12 46.7 11.7 2e-12 46.7 11.7 3.1 2 1 1 3 3 3 1 Sugar (and other) transporter SSP160 PF06933.11 CCF40715.1 - 0.11 10.6 3.9 0.13 10.4 3.9 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 NPCBM_assoc PF10633.9 CCF40717.1 - 0.15 12.3 0.0 0.18 12.1 0.0 1.1 1 0 0 1 1 1 0 NPCBM-associated, NEW3 domain of alpha-galactosidase Peptidase_M28 PF04389.17 CCF40719.1 - 1.1e-34 119.9 0.0 1.9e-34 119.1 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 CCF40719.1 - 0.049 13.3 0.0 0.082 12.6 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M20/M25/M40 Tcp11 PF05794.13 CCF40720.1 - 9.6e-100 334.7 0.1 9.6e-100 334.7 0.1 2.5 3 0 0 3 3 3 1 T-complex protein 11 DUF2955 PF11168.8 CCF40722.1 - 0.0037 17.1 1.8 0.0073 16.2 1.8 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2955) Fungal_trans_2 PF11951.8 CCF40723.1 - 2e-12 46.6 3.5 1.6e-08 33.8 1.6 2.1 2 0 0 2 2 2 2 Fungal specific transcription factor domain F-box-like PF12937.7 CCF40724.1 - 2.9e-05 23.9 0.2 0.00011 22.1 0.2 2.0 2 0 0 2 2 2 1 F-box-like F-box_4 PF15966.5 CCF40724.1 - 0.012 15.5 0.1 0.022 14.6 0.1 1.4 1 0 0 1 1 1 0 F-box MFS_1 PF07690.16 CCF40726.1 - 4e-08 32.6 30.8 4e-08 32.6 30.8 2.2 1 1 0 2 2 2 1 Major Facilitator Superfamily DNA_pol_E_B PF04042.16 CCF40727.1 - 1.9e-50 171.2 0.0 2.7e-50 170.7 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B DNA_pol_D_N PF18018.1 CCF40727.1 - 6.7e-39 133.0 0.0 1.1e-38 132.3 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase delta subunit OB-fold domain Elong-fact-P_C PF09285.11 CCF40727.1 - 0.14 11.9 0.4 0.5 10.2 0.1 2.0 2 0 0 2 2 2 0 Elongation factor P, C-terminal MFS_1 PF07690.16 CCF40729.1 - 1.1e-13 50.8 17.8 1.3e-13 50.7 17.8 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily OppC_N PF12911.7 CCF40729.1 - 0.14 12.2 1.9 0.96 9.5 0.0 2.9 3 0 0 3 3 3 0 N-terminal TM domain of oligopeptide transport permease C MFS_1 PF07690.16 CCF40730.1 - 0.00012 21.2 0.1 0.00021 20.3 0.1 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily 2-Hacid_dh_C PF02826.19 CCF40731.1 - 3.4e-52 176.4 0.1 4.8e-52 175.9 0.1 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CCF40731.1 - 1.5e-23 82.9 0.1 1.9e-23 82.6 0.1 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain AlaDh_PNT_C PF01262.21 CCF40731.1 - 0.00088 18.6 0.9 0.0031 16.8 0.9 1.9 1 1 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain AdoHcyase_NAD PF00670.21 CCF40731.1 - 0.0028 17.7 0.0 0.0055 16.8 0.0 1.4 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain NAD_binding_2 PF03446.15 CCF40731.1 - 0.0072 16.5 0.0 0.016 15.4 0.0 1.6 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_Gly3P_dh_N PF01210.23 CCF40731.1 - 0.023 14.7 0.1 0.073 13.0 0.1 1.8 1 1 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus DUF1348 PF07080.11 CCF40732.1 - 5.9e-58 194.4 7.9 7.2e-58 194.1 7.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1348) SnoaL_2 PF12680.7 CCF40732.1 - 0.012 16.3 0.4 0.018 15.7 0.4 1.3 1 0 0 1 1 1 0 SnoaL-like domain STE3 PF02076.15 CCF40733.1 - 6.5e-13 48.5 0.6 8.3e-13 48.2 0.6 1.1 1 0 0 1 1 1 1 Pheromone A receptor DUF3530 PF12048.8 CCF40734.1 - 0.15 11.5 0.2 0.15 11.5 0.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) DUF3328 PF11807.8 CCF40735.1 - 1.1e-16 61.3 0.4 1.6e-16 60.7 0.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) zf-C2H2_4 PF13894.6 CCF40736.1 - 0.01 16.6 3.7 2.2 9.3 0.9 3.2 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.26 CCF40736.1 - 0.011 16.2 3.9 0.22 12.1 0.1 2.9 2 0 0 2 2 2 0 Zinc finger, C2H2 type Ribosom_S12_S23 PF00164.25 CCF40741.1 - 6.9e-23 80.4 0.2 9.1e-23 80.1 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 DUF5315 PF17242.2 CCF40742.1 - 1.8e-30 104.6 0.8 3.7e-30 103.5 0.8 1.5 1 0 0 1 1 1 1 Disordered region of unknown function (DUF5315) Aldedh PF00171.22 CCF40744.1 - 1.4e-107 360.1 0.0 1.7e-107 359.8 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family PhoD PF09423.10 CCF40745.1 - 5.3e-07 29.0 1.6 8.4e-05 21.7 0.2 2.4 3 0 0 3 3 3 2 PhoD-like phosphatase RNB PF00773.19 CCF40746.1 - 1.4e-98 330.3 0.0 1.8e-98 329.9 0.0 1.1 1 0 0 1 1 1 1 RNB domain Rrp44_S1 PF17215.3 CCF40746.1 - 2.3e-32 110.8 0.2 7.9e-32 109.1 0.3 1.9 2 0 0 2 2 2 1 S1 domain OB_Dis3 PF17849.1 CCF40746.1 - 2.3e-17 62.8 0.0 5.2e-17 61.6 0.0 1.7 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) Dis3l2_C_term PF17877.1 CCF40746.1 - 0.0055 17.0 0.0 0.015 15.6 0.0 1.7 1 0 0 1 1 1 1 DIS3-like exonuclease 2 C terminal CSD2 PF17876.1 CCF40746.1 - 0.007 16.5 0.0 0.04 14.1 0.0 2.1 2 0 0 2 2 2 1 Cold shock domain Fungal_trans PF04082.18 CCF40747.1 - 8.1e-11 41.4 0.0 1.6e-10 40.5 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF40747.1 - 3.1e-07 30.4 12.4 5.6e-07 29.6 12.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Abhydrolase_1 PF00561.20 CCF40748.1 - 2.5e-11 43.7 0.9 1.2e-09 38.3 0.8 2.5 2 1 0 3 3 3 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCF40748.1 - 5.6e-11 43.5 0.2 8.1e-11 42.9 0.2 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCF40748.1 - 3.5e-09 36.3 0.1 4.9e-09 35.8 0.1 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 CSTF2_hinge PF14327.6 CCF40751.1 - 1.1e-29 102.7 3.2 2.9e-29 101.3 3.2 1.7 1 0 0 1 1 1 1 Hinge domain of cleavage stimulation factor subunit 2 Fungal_trans PF04082.18 CCF40751.1 - 3.6e-19 68.8 0.0 6.1e-19 68.1 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain CSTF_C PF14304.6 CCF40751.1 - 1.9e-10 40.1 1.2 1.9e-10 40.1 1.2 2.7 3 0 0 3 3 3 1 Transcription termination and cleavage factor C-terminal Fungal_trans PF04082.18 CCF40752.1 - 3.8e-16 58.9 0.0 5.9e-16 58.3 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF40752.1 - 8.4e-08 32.2 7.7 1.6e-07 31.4 7.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MGTL PF17059.5 CCF40752.1 - 0.18 11.7 0.8 0.58 10.0 0.8 1.9 1 0 0 1 1 1 0 MgtA leader peptide Cellulase PF00150.18 CCF40753.1 - 1.7e-06 27.7 0.0 7.1e-06 25.6 0.0 1.8 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) DEAD PF00270.29 CCF40754.1 - 2.9e-37 128.1 0.0 2.4e-36 125.1 0.0 2.4 2 1 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF40754.1 - 4.1e-24 85.1 0.0 1e-23 83.8 0.0 1.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 CCF40754.1 - 5.9e-20 71.3 0.0 1.2e-19 70.3 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 CCF40754.1 - 0.012 15.7 0.0 0.043 13.8 0.0 1.9 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit Zn_clus PF00172.18 CCF40755.1 - 1.4e-08 34.7 10.2 2.3e-08 34.0 10.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CCF40755.1 - 0.00025 20.2 0.0 0.00034 19.7 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-Mss51 PF13824.6 CCF40756.1 - 4.2e-08 33.2 2.9 7.8e-08 32.3 2.9 1.5 1 0 0 1 1 1 1 Zinc-finger of mitochondrial splicing suppressor 51 PXA PF02194.15 CCF40757.1 - 2.1e-48 164.7 0.9 3e-48 164.2 0.9 1.2 1 0 0 1 1 1 1 PXA domain Cutinase PF01083.22 CCF40758.1 - 2.3e-45 154.7 1.6 2.9e-45 154.4 1.6 1.1 1 0 0 1 1 1 1 Cutinase DUF2974 PF11187.8 CCF40758.1 - 0.011 15.3 0.1 0.022 14.3 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) PE-PPE PF08237.11 CCF40758.1 - 0.022 14.3 0.2 0.03 13.9 0.2 1.2 1 0 0 1 1 1 0 PE-PPE domain Aminotran_3 PF00202.21 CCF40759.1 - 8.6e-114 380.3 0.0 1.1e-113 379.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 CCF40759.1 - 3.7e-05 23.1 0.0 7.5e-05 22.1 0.0 1.6 1 1 0 1 1 1 1 Aminotransferase class I and II HET PF06985.11 CCF40760.1 - 1.2e-38 132.7 0.4 2.2e-38 131.9 0.4 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Abhydrolase_3 PF07859.13 CCF40761.1 - 1.7e-33 116.3 0.0 9.4e-24 84.4 0.0 2.4 2 0 0 2 2 2 2 alpha/beta hydrolase fold Lipase_3 PF01764.25 CCF40761.1 - 0.085 12.7 0.0 0.21 11.4 0.0 1.6 1 0 0 1 1 1 0 Lipase (class 3) Say1_Mug180 PF10340.9 CCF40761.1 - 0.15 10.9 0.0 0.23 10.3 0.0 1.2 1 0 0 1 1 1 0 Steryl acetyl hydrolase Pkinase PF00069.25 CCF40763.1 - 3.2e-64 216.8 0.0 3.8e-64 216.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF40763.1 - 3.5e-25 88.8 0.0 4.6e-25 88.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF40763.1 - 2.1e-06 27.3 0.0 9.9e-06 25.1 0.0 1.9 1 1 1 2 2 2 1 Kinase-like APH PF01636.23 CCF40763.1 - 0.0034 17.3 0.1 0.014 15.3 0.0 1.9 2 1 1 3 3 3 1 Phosphotransferase enzyme family DUF1229 PF06797.11 CCF40763.1 - 0.006 16.8 0.2 0.0095 16.2 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1229) Kdo PF06293.14 CCF40763.1 - 0.1 11.9 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 CCF40763.1 - 0.15 11.7 0.0 0.25 10.9 0.0 1.5 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Zn_clus PF00172.18 CCF40764.1 - 1.8e-06 28.0 8.2 3.6e-06 27.0 8.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4570 PF15134.6 CCF40764.1 - 0.1 12.6 0.1 0.21 11.6 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4570) Aldo_ket_red PF00248.21 CCF40765.1 - 3.3e-47 161.1 0.0 3.9e-47 160.8 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family TBPIP PF07106.13 CCF40765.1 - 0.05 13.5 0.0 32 4.6 0.0 3.2 2 1 1 3 3 3 0 TBPIP/Hop2 winged helix domain Shal-type PF11601.8 CCF40765.1 - 0.072 12.6 0.2 0.15 11.6 0.2 1.5 1 0 0 1 1 1 0 Shal-type voltage-gated potassium channels, N-terminal PUF PF00806.19 CCF40767.1 - 2.9e-60 196.7 11.3 1.6e-07 30.6 0.0 8.2 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat DIOX_N PF14226.6 CCF40769.1 - 1.1e-18 68.1 0.0 1.7e-18 67.5 0.0 1.2 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 CCF40769.1 - 7.5e-15 55.3 0.0 1.5e-14 54.3 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily MKT1_C PF12246.8 CCF40770.1 - 3.9e-74 248.9 0.1 5.9e-74 248.3 0.1 1.3 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication MKT1_N PF12247.8 CCF40770.1 - 6.4e-31 106.6 0.0 1.2e-30 105.7 0.0 1.5 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication UQ_con PF00179.26 CCF40772.1 - 1.6e-52 176.8 0.0 1.8e-52 176.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 CCF40772.1 - 0.0048 16.6 0.0 0.0059 16.3 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 CCF40772.1 - 0.037 14.3 0.0 0.045 14.0 0.0 1.2 1 0 0 1 1 1 0 RWD domain UEV PF05743.13 CCF40772.1 - 0.046 13.6 0.0 0.072 13.0 0.0 1.3 1 0 0 1 1 1 0 UEV domain Alk_phosphatase PF00245.20 CCF40773.1 - 7.9e-72 242.5 0.0 1.6e-71 241.5 0.0 1.5 1 1 0 1 1 1 1 Alkaline phosphatase Sulfatase PF00884.23 CCF40773.1 - 1.5e-05 24.6 0.1 2.6e-05 23.8 0.1 1.4 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 CCF40773.1 - 0.00043 20.0 0.1 0.00065 19.4 0.1 1.3 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.17 CCF40773.1 - 0.0054 15.4 0.1 0.0079 14.8 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF229) ODV-E18 PF10717.9 CCF40773.1 - 0.1 12.4 0.8 0.25 11.2 0.8 1.6 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 MFS_1 PF07690.16 CCF40774.1 - 1.6e-26 93.1 33.9 2.1e-26 92.7 33.9 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF3487 PF11990.8 CCF40774.1 - 2.9 7.8 6.9 1.6 8.6 0.2 3.4 3 1 0 3 3 3 0 Protein of unknown function (DUF3487) OPT PF03169.15 CCF40775.1 - 2.4e-118 396.4 39.9 2.7e-118 396.3 39.9 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein KdpC PF02669.15 CCF40776.1 - 0.13 12.1 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 K+-transporting ATPase, c chain Epimerase PF01370.21 CCF40776.1 - 0.17 11.3 0.0 0.26 10.7 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Glyco_hydro_18 PF00704.28 CCF40777.1 - 9e-78 262.1 0.8 1.1e-77 261.9 0.8 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 HTH_psq PF05225.16 CCF40778.1 - 8.9e-12 44.6 0.1 1.6e-11 43.7 0.1 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.16 CCF40778.1 - 1.9e-11 43.8 0.6 8.6e-11 41.7 0.0 2.2 3 0 0 3 3 3 1 Tc5 transposase DNA-binding domain HTH_23 PF13384.6 CCF40778.1 - 0.00012 21.7 0.1 0.00039 20.1 0.1 1.9 1 1 0 1 1 1 1 Homeodomain-like domain HTH_7 PF02796.15 CCF40778.1 - 0.00075 19.5 0.1 0.0014 18.7 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_30 PF13556.6 CCF40778.1 - 0.002 17.9 0.1 0.0051 16.6 0.1 1.7 2 0 0 2 2 2 1 PucR C-terminal helix-turn-helix domain HTH_28 PF13518.6 CCF40778.1 - 0.0065 16.6 1.1 0.014 15.5 0.1 2.1 2 1 1 3 3 3 1 Helix-turn-helix domain HTH_Tnp_1 PF01527.20 CCF40778.1 - 0.014 15.7 0.3 0.031 14.6 0.3 1.8 1 1 0 1 1 1 0 Transposase HTH_1 PF00126.27 CCF40778.1 - 0.035 14.0 0.8 0.072 13.1 0.8 1.5 1 0 0 1 1 1 0 Bacterial regulatory helix-turn-helix protein, lysR family CENP-B_N PF04218.13 CCF40778.1 - 0.066 12.9 0.0 0.15 11.7 0.0 1.5 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain SpoIIID PF12116.8 CCF40778.1 - 0.13 12.4 0.0 0.24 11.5 0.0 1.5 1 0 0 1 1 1 0 Stage III sporulation protein D Phosducin PF02114.16 CCF40781.1 - 4.8e-12 45.4 0.1 7.3e-12 44.8 0.1 1.2 1 0 0 1 1 1 1 Phosducin Thioredoxin PF00085.20 CCF40781.1 - 0.0037 17.2 0.0 0.006 16.5 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin LRR_4 PF12799.7 CCF40782.1 - 2.3e-06 27.8 0.3 1.7e-05 25.1 0.2 2.5 2 0 0 2 2 2 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCF40782.1 - 4e-06 26.5 0.8 9.1e-06 25.4 0.6 1.8 2 0 0 2 2 2 1 Leucine rich repeat LRR_1 PF00560.33 CCF40782.1 - 0.0073 16.7 1.1 6.1 7.8 0.0 4.0 3 0 0 3 3 3 1 Leucine Rich Repeat LRR_6 PF13516.6 CCF40782.1 - 0.13 12.4 2.2 7 7.0 0.1 2.8 2 0 0 2 2 2 0 Leucine Rich repeat polyprenyl_synt PF00348.17 CCF40783.1 - 4e-65 219.4 0.0 5.1e-65 219.1 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase Pex24p PF06398.11 CCF40784.1 - 6.2e-88 295.2 0.0 7.3e-88 295.0 0.0 1.1 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin DUF3292 PF11696.8 CCF40784.1 - 0.011 14.1 3.0 0.012 14.0 0.7 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3292) Reticulon PF02453.17 CCF40784.1 - 0.018 15.0 1.6 0.054 13.4 1.6 1.7 1 1 0 1 1 1 0 Reticulon DUF639 PF04842.12 CCF40784.1 - 0.6 9.5 2.1 0.39 10.1 0.2 1.6 2 0 0 2 2 2 0 Plant protein of unknown function (DUF639) THOC2_N PF16134.5 CCF40787.1 - 1.9e-189 631.4 0.0 2.3e-189 631.1 0.0 1.0 1 0 0 1 1 1 1 THO complex subunit 2 N-terminus Thoc2 PF11732.8 CCF40787.1 - 1.6e-28 98.6 0.1 3.4e-28 97.5 0.1 1.6 1 0 0 1 1 1 1 Transcription- and export-related complex subunit RVT_1 PF00078.27 CCF40788.1 - 1.7e-40 138.9 0.0 2.9e-40 138.2 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 CCF40788.1 - 9.3e-21 73.9 0.1 2.7e-20 72.4 0.1 1.9 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 CCF40788.1 - 4.5e-08 32.9 0.3 8.7e-08 32.0 0.3 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family G_glu_transpept PF01019.21 CCF40789.1 - 5.9e-129 431.1 0.5 1.1e-66 225.7 0.5 2.0 1 1 1 2 2 2 2 Gamma-glutamyltranspeptidase DJ-1_PfpI PF01965.24 CCF40790.1 - 7.4e-08 32.4 0.0 3.6e-07 30.1 0.0 2.1 1 1 0 1 1 1 1 DJ-1/PfpI family DUF1688 PF07958.11 CCF40792.1 - 6.8e-178 591.7 0.0 7.8e-178 591.5 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1688) PLDc PF00614.22 CCF40793.1 - 5e-08 32.8 0.1 1.2e-07 31.6 0.1 1.7 1 0 0 1 1 1 1 Phospholipase D Active site motif PLDc_2 PF13091.6 CCF40793.1 - 6e-05 22.9 0.0 0.00033 20.5 0.0 2.1 2 0 0 2 2 2 1 PLD-like domain RNB PF00773.19 CCF40794.1 - 1e-40 140.1 0.0 1.6e-40 139.5 0.0 1.2 1 0 0 1 1 1 1 RNB domain PAP_assoc PF03828.19 CCF40795.1 - 1.7e-13 50.6 0.0 3.6e-13 49.5 0.0 1.6 1 0 0 1 1 1 1 Cid1 family poly A polymerase Condensation PF00668.20 CCF40796.1 - 7.9e-47 160.0 0.0 1e-46 159.6 0.0 1.1 1 0 0 1 1 1 1 Condensation domain PP-binding PF00550.25 CCF40796.1 - 4.5e-08 33.3 0.1 1.1e-07 32.1 0.1 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site SPOR PF05036.13 CCF40796.1 - 0.051 13.9 0.0 0.16 12.4 0.0 1.9 1 0 0 1 1 1 0 Sporulation related domain AA_permease_2 PF13520.6 CCF40797.1 - 5.9e-42 144.0 17.1 2.4e-41 142.0 17.1 1.7 1 1 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CCF40797.1 - 8.1e-07 28.0 19.6 3.1e-06 26.1 19.6 1.8 1 1 0 1 1 1 1 Amino acid permease DUF4632 PF15451.6 CCF40798.1 - 0.029 14.4 0.1 0.69 10.0 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4632) Allantoicase PF03561.15 CCF40798.1 - 0.11 12.5 0.0 0.15 12.0 0.0 1.1 1 0 0 1 1 1 0 Allantoicase repeat EST1 PF10374.9 CCF40798.1 - 0.52 10.9 3.4 50 4.5 0.0 3.1 3 0 0 3 3 3 0 Telomerase activating protein Est1 Rad50_zn_hook PF04423.14 CCF40799.1 - 0.0011 18.7 0.1 0.0018 18.0 0.1 1.4 1 0 0 1 1 1 1 Rad50 zinc hook motif zf-Di19 PF05605.12 CCF40799.1 - 0.045 14.0 0.1 0.13 12.6 0.1 1.7 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_12 PF18658.1 CCF40799.1 - 0.084 12.5 0.0 0.17 11.5 0.0 1.5 1 1 0 1 1 1 0 Zinc-finger C2H2-type Pkinase PF00069.25 CCF40800.1 - 7.5e-57 192.7 0.0 1.1e-56 192.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF40800.1 - 3.3e-35 121.6 0.0 4.9e-35 121.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF40800.1 - 9.3e-12 44.8 0.0 6.9e-10 38.7 0.0 2.1 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 CCF40800.1 - 0.01 15.8 0.1 0.53 10.1 0.0 2.3 2 0 0 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 CCF40800.1 - 0.083 12.2 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family EF-1_beta_acid PF10587.9 CCF40800.1 - 5.8 7.5 9.8 13 6.3 9.8 1.6 1 0 0 1 1 1 0 Eukaryotic elongation factor 1 beta central acidic region Epimerase PF01370.21 CCF40801.1 - 4.9e-11 42.6 0.2 1.6e-10 40.9 0.2 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CCF40801.1 - 1.7e-07 31.4 0.6 8.2e-07 29.1 0.3 2.2 1 1 1 2 2 2 1 NAD(P)H-binding NAD_binding_4 PF07993.12 CCF40801.1 - 1.1e-06 28.0 0.4 0.00051 19.3 0.1 2.2 1 1 1 2 2 2 2 Male sterility protein NmrA PF05368.13 CCF40801.1 - 4.4e-05 23.1 0.3 0.00019 21.1 0.1 1.9 2 0 0 2 2 2 1 NmrA-like family 3Beta_HSD PF01073.19 CCF40801.1 - 8.7e-05 21.7 0.0 0.00027 20.1 0.0 1.8 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family TrkA_N PF02254.18 CCF40801.1 - 0.053 13.8 0.0 0.33 11.2 0.0 2.1 2 0 0 2 2 2 0 TrkA-N domain KRTAP PF11759.8 CCF40804.1 - 0.99 10.0 14.0 0.8 10.3 12.0 1.9 2 0 0 2 2 2 0 Keratin-associated matrix XPG_I PF00867.18 CCF40805.1 - 7.3e-22 77.5 0.0 2e-21 76.1 0.0 1.8 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 CCF40805.1 - 3.4e-06 27.5 0.0 7.9e-06 26.3 0.0 1.6 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I_2 PF12813.7 CCF40805.1 - 4.6e-05 23.0 0.0 9.7e-05 22.0 0.0 1.5 1 0 0 1 1 1 1 XPG domain containing 5_3_exonuc PF01367.20 CCF40805.1 - 0.018 15.7 0.0 0.064 13.9 0.0 1.9 2 0 0 2 2 2 0 5'-3' exonuclease, C-terminal SAM fold HHH_5 PF14520.6 CCF40805.1 - 0.12 13.0 0.1 12 6.6 0.0 2.7 2 0 0 2 2 2 0 Helix-hairpin-helix domain Tma16 PF11176.8 CCF40806.1 - 4.6e-47 159.6 0.3 5.6e-47 159.3 0.3 1.1 1 0 0 1 1 1 1 Translation machinery-associated protein 16 FliJ PF02050.16 CCF40806.1 - 0.037 14.3 1.8 0.037 14.3 1.8 1.8 3 0 0 3 3 3 0 Flagellar FliJ protein MAM33 PF02330.16 CCF40807.1 - 1.9e-76 256.7 0.5 2.8e-76 256.2 0.5 1.3 1 0 0 1 1 1 1 Mitochondrial glycoprotein CAP PF00188.26 CCF40808.1 - 3.7e-22 79.5 2.1 4.6e-22 79.2 2.1 1.1 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Mannosyl_trans3 PF11051.8 CCF40810.1 - 2.6e-40 138.5 0.0 6.1e-40 137.3 0.0 1.6 1 1 0 1 1 1 1 Mannosyltransferase putative Glyco_hydro_3 PF00933.21 CCF40811.1 - 1.1e-37 130.1 0.0 1.4e-37 129.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.22 CCF40811.1 - 3.1e-06 27.3 0.0 0.0003 20.8 0.0 2.3 1 1 1 2 2 2 2 Glycosyl hydrolase family 3 C-terminal domain AA_permease PF00324.21 CCF40812.1 - 1.1e-06 27.6 6.7 1.7e-06 27.0 6.7 1.3 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CCF40812.1 - 2.4e-06 26.7 9.8 2.6e-06 26.6 9.8 1.0 1 0 0 1 1 1 1 Amino acid permease DUF1576 PF07613.11 CCF40812.1 - 0.081 12.4 1.6 0.092 12.3 1.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1576) OPT PF03169.15 CCF40813.1 - 1.5e-45 156.0 39.1 1.7e-45 155.8 39.1 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein ACT PF01842.25 CCF40814.1 - 0.00028 20.6 0.0 0.00038 20.2 0.0 1.2 1 0 0 1 1 1 1 ACT domain p450 PF00067.22 CCF40816.1 - 1.3e-48 165.9 0.0 1.6e-48 165.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 F-box-like PF12937.7 CCF40817.1 - 1.3e-05 25.0 0.1 2.8e-05 23.9 0.1 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCF40817.1 - 0.00021 21.1 0.1 0.00046 20.0 0.1 1.6 1 0 0 1 1 1 1 F-box domain HAGH_C PF16123.5 CCF40817.1 - 0.14 12.7 0.0 0.37 11.3 0.0 1.7 1 0 0 1 1 1 0 Hydroxyacylglutathione hydrolase C-terminus Methyltransf_23 PF13489.6 CCF40818.1 - 4.9e-24 85.0 0.0 7.7e-24 84.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF40818.1 - 1.1e-10 42.1 0.0 2.9e-10 40.7 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF40818.1 - 2.2e-08 34.6 0.0 4.3e-08 33.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF40818.1 - 3.1e-08 33.6 0.0 6e-07 29.4 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF40818.1 - 2.6e-07 31.3 0.0 3.3e-06 27.7 0.0 2.6 2 1 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 CCF40818.1 - 0.0032 17.0 0.0 0.0058 16.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain DREV PF05219.12 CCF40818.1 - 0.0061 15.7 0.0 0.011 14.8 0.0 1.3 1 0 0 1 1 1 1 DREV methyltransferase Methyltransf_2 PF00891.18 CCF40818.1 - 0.014 14.7 0.0 0.042 13.1 0.0 1.7 2 0 0 2 2 2 0 O-methyltransferase domain LpqV PF17301.2 CCF40818.1 - 0.066 13.5 1.6 0.11 12.7 1.6 1.4 1 0 0 1 1 1 0 Putative lipoprotein LpqV PrmA PF06325.13 CCF40818.1 - 0.11 11.9 0.0 0.2 11.0 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) OST-HTH PF12872.7 CCF40818.1 - 0.13 12.1 0.3 2.7 7.9 0.0 3.0 4 0 0 4 4 4 0 OST-HTH/LOTUS domain p450 PF00067.22 CCF40819.1 - 3.3e-77 260.2 0.0 4.4e-77 259.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 FAD_binding_1 PF00667.20 CCF40819.1 - 8.9e-27 94.1 0.0 3e-26 92.4 0.0 1.8 2 0 0 2 2 2 1 FAD binding domain Flavodoxin_1 PF00258.25 CCF40819.1 - 1.3e-26 93.5 0.0 2.6e-26 92.5 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 CCF40819.1 - 6.3e-12 46.1 0.0 1.8e-11 44.7 0.0 1.8 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Flavodoxin_5 PF12724.7 CCF40819.1 - 0.0001 22.6 0.0 0.00098 19.4 0.0 2.2 2 0 0 2 2 2 1 Flavodoxin domain DcpS PF05652.12 CCF40820.1 - 3e-36 124.4 0.0 4.6e-36 123.8 0.0 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme (DcpS) N-terminal DcpS_C PF11969.8 CCF40820.1 - 1.7e-32 112.2 0.1 2.6e-32 111.7 0.1 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding GILT PF03227.16 CCF40821.1 - 6.4e-19 68.2 0.1 9.9e-19 67.6 0.1 1.3 1 0 0 1 1 1 1 Gamma interferon inducible lysosomal thiol reductase (GILT) TMCO5 PF14992.6 CCF40822.1 - 0.2 11.2 3.5 0.31 10.6 3.5 1.2 1 0 0 1 1 1 0 TMCO5 family Glyco_transf_90 PF05686.12 CCF40823.1 - 1.1e-13 50.9 1.7 1.4e-10 40.7 0.0 2.7 3 0 0 3 3 3 2 Glycosyl transferase family 90 Nop53 PF07767.11 CCF40824.1 - 3.5e-40 138.6 15.0 4.2e-40 138.4 15.0 1.1 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) HTH_32 PF13565.6 CCF40824.1 - 3.7 8.2 8.5 0.19 12.4 2.0 2.2 2 1 0 2 2 2 0 Homeodomain-like domain Pyr_redox_2 PF07992.14 CCF40825.1 - 1.4e-41 142.7 0.0 2e-41 142.2 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCF40825.1 - 3.6e-14 53.1 0.0 1.4e-09 38.3 0.0 3.5 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase EF-hand_1 PF00036.32 CCF40825.1 - 7.2e-07 28.3 0.4 1.5e-06 27.3 0.4 1.6 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 CCF40825.1 - 8.1e-06 25.4 0.6 2.5e-05 23.8 0.6 1.9 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.6 CCF40825.1 - 4.2e-05 22.8 1.4 9.4e-05 21.7 1.4 1.5 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 CCF40825.1 - 8.9e-05 22.9 0.2 0.00021 21.7 0.2 1.6 1 0 0 1 1 1 1 EF-hand domain pair PCRF PF03462.18 CCF40825.1 - 0.015 15.1 0.0 0.2 11.5 0.0 2.1 2 0 0 2 2 2 0 PCRF domain PTPS PF01242.19 CCF40825.1 - 0.036 14.0 0.1 6.6 6.7 0.0 2.7 3 0 0 3 3 3 0 6-pyruvoyl tetrahydropterin synthase Spc24 PF08286.11 CCF40825.1 - 0.15 12.4 0.0 0.28 11.4 0.0 1.4 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 Methyltransf_23 PF13489.6 CCF40826.1 - 1.3e-22 80.4 0.0 2.7e-22 79.3 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF40826.1 - 1.2e-12 48.4 0.0 4.5e-12 46.5 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF40826.1 - 1.1e-10 42.1 0.0 2.7e-10 40.7 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF40826.1 - 6.7e-10 39.0 0.0 2.7e-08 33.8 0.0 2.5 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF40826.1 - 5.4e-08 33.5 0.0 4.6e-07 30.5 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 CCF40826.1 - 0.00097 18.6 0.0 0.0022 17.5 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase FtsJ PF01728.19 CCF40826.1 - 0.002 18.3 0.0 0.004 17.3 0.0 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase CMAS PF02353.20 CCF40826.1 - 0.0046 16.3 0.0 0.0085 15.4 0.0 1.4 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_2 PF00891.18 CCF40826.1 - 0.019 14.3 0.0 0.039 13.2 0.0 1.5 1 0 0 1 1 1 0 O-methyltransferase domain MTS PF05175.14 CCF40826.1 - 0.024 14.2 0.0 0.062 12.9 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase small domain Ubie_methyltran PF01209.18 CCF40826.1 - 0.068 12.5 0.0 1.1 8.5 0.0 2.5 2 1 0 2 2 2 0 ubiE/COQ5 methyltransferase family FAD_binding_3 PF01494.19 CCF40830.1 - 1.2e-13 51.1 0.0 1.4e-13 50.8 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain SE PF08491.10 CCF40830.1 - 0.059 12.4 0.0 0.073 12.1 0.0 1.2 1 0 0 1 1 1 0 Squalene epoxidase 2-Hacid_dh_C PF02826.19 CCF40831.1 - 7.9e-51 171.9 0.0 1.1e-50 171.5 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 CCF40831.1 - 4.8e-06 26.8 0.3 1e-05 25.8 0.3 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh PF00389.30 CCF40831.1 - 0.00082 19.0 0.0 0.0017 18.0 0.0 1.4 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain AdoHcyase_NAD PF00670.21 CCF40831.1 - 0.00095 19.3 0.1 0.0016 18.5 0.1 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain IlvN PF07991.12 CCF40831.1 - 0.0023 17.5 0.0 0.0038 16.8 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain 3HCDH_N PF02737.18 CCF40831.1 - 0.0062 16.4 2.4 0.75 9.6 0.4 2.5 2 1 1 3 3 3 2 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain XdhC_C PF13478.6 CCF40831.1 - 0.0062 17.0 0.0 0.01 16.3 0.0 1.3 1 0 0 1 1 1 1 XdhC Rossmann domain ACT PF01842.25 CCF40831.1 - 0.052 13.3 0.0 0.12 12.2 0.0 1.7 1 0 0 1 1 1 0 ACT domain GMC_oxred_N PF00732.19 CCF40832.1 - 1.1e-51 176.0 0.0 1.4e-51 175.7 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase DAO PF01266.24 CCF40832.1 - 1.5e-06 28.0 0.0 2.4e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CCF40832.1 - 3e-06 26.6 0.1 0.0051 15.9 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_3 PF13738.6 CCF40832.1 - 0.00021 20.7 0.0 0.001 18.4 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCF40832.1 - 0.00029 21.0 0.0 0.00085 19.5 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 CCF40832.1 - 0.00044 19.4 0.1 0.00064 18.9 0.1 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Thi4 PF01946.17 CCF40832.1 - 0.00052 19.3 0.2 0.0013 18.0 0.0 1.6 2 0 0 2 2 2 1 Thi4 family Pyr_redox_2 PF07992.14 CCF40832.1 - 0.0013 18.0 0.1 0.01 15.1 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CCF40832.1 - 0.0069 15.1 0.0 0.12 11.1 0.0 2.0 2 0 0 2 2 2 1 HI0933-like protein NAD_binding_9 PF13454.6 CCF40832.1 - 0.11 12.5 0.2 0.29 11.1 0.0 1.8 2 0 0 2 2 2 0 FAD-NAD(P)-binding RhoGAP PF00620.27 CCF40833.1 - 2.2e-46 157.5 1.8 6.9e-46 155.8 0.0 2.6 2 2 1 3 3 3 1 RhoGAP domain DUF4407 PF14362.6 CCF40833.1 - 0.046 13.1 4.5 0.085 12.2 4.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SlyX PF04102.12 CCF40833.1 - 0.053 14.1 0.8 0.053 14.1 0.8 3.6 3 1 1 4 4 4 0 SlyX IFT20 PF14931.6 CCF40833.1 - 0.3 11.3 9.2 0.034 14.3 1.3 2.4 2 0 0 2 2 2 0 Intraflagellar transport complex B, subunit 20 TMF_TATA_bd PF12325.8 CCF40833.1 - 0.42 10.8 11.4 0.18 12.0 3.0 3.4 3 1 0 3 3 3 0 TATA element modulatory factor 1 TATA binding Fez1 PF06818.15 CCF40833.1 - 1.1 9.6 11.6 2.8 8.3 11.6 1.6 1 0 0 1 1 1 0 Fez1 APG6_N PF17675.1 CCF40833.1 - 1.2 9.7 12.6 0.26 11.8 7.5 2.4 1 1 1 2 2 2 0 Apg6 coiled-coil region PRKG1_interact PF15898.5 CCF40833.1 - 1.3 9.9 8.4 20 6.1 0.2 2.8 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain DUF948 PF06103.11 CCF40833.1 - 1.8 8.8 7.3 19 5.6 0.7 3.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) KASH_CCD PF14662.6 CCF40833.1 - 3.3 7.5 15.3 24 4.7 15.3 2.1 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH Metal_resist PF13801.6 CCF40833.1 - 9.5 6.4 8.7 10 6.4 6.9 2.0 2 0 0 2 2 2 0 Heavy-metal resistance ATP-synt_B PF00430.18 CCF40834.1 - 0.14 12.3 9.9 0.18 11.9 9.9 1.1 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) DUF4407 PF14362.6 CCF40834.1 - 1.4 8.2 5.7 1.4 8.2 5.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) NmrA PF05368.13 CCF40836.1 - 4.8e-21 75.4 0.4 6.1e-21 75.1 0.4 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CCF40836.1 - 5.7e-18 65.5 0.0 1.2e-17 64.4 0.0 1.5 1 0 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 CCF40836.1 - 2.8e-07 30.9 0.8 0.0021 18.3 0.1 2.2 2 0 0 2 2 2 2 Saccharopine dehydrogenase NADP binding domain 3Beta_HSD PF01073.19 CCF40836.1 - 0.00086 18.4 0.1 0.0029 16.7 0.0 1.8 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 CCF40836.1 - 0.0028 17.1 0.1 0.0067 15.9 0.0 1.7 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family Shikimate_DH PF01488.20 CCF40836.1 - 0.035 14.2 0.5 0.063 13.3 0.1 1.5 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase DUF2280 PF10045.9 CCF40836.1 - 0.038 14.3 0.2 0.087 13.1 0.2 1.6 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2280) Acetyltransf_7 PF13508.7 CCF40837.1 - 3.1e-06 27.5 0.0 1.4e-05 25.4 0.0 2.0 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CCF40837.1 - 5.8e-05 23.3 0.0 0.0001 22.5 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CCF40837.1 - 9.2e-05 22.4 0.0 0.00021 21.2 0.0 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain MOZ_SAS PF01853.18 CCF40837.1 - 0.24 11.1 0.0 0.34 10.5 0.0 1.2 1 0 0 1 1 1 0 MOZ/SAS family MAPEG PF01124.18 CCF40839.1 - 7.2e-21 74.5 0.2 8.4e-21 74.2 0.2 1.0 1 0 0 1 1 1 1 MAPEG family EthD PF07110.11 CCF40841.1 - 5.9e-22 78.6 0.1 8.4e-22 78.1 0.1 1.2 1 0 0 1 1 1 1 EthD domain MmlI PF09448.10 CCF40841.1 - 0.002 18.6 0.0 0.0028 18.1 0.0 1.3 1 0 0 1 1 1 1 Methylmuconolactone methyl-isomerase tRNA-synt_1e PF01406.19 CCF40842.1 - 6.3e-112 373.8 0.1 8.5e-112 373.4 0.1 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 CCF40842.1 - 1.7e-06 27.0 0.2 0.032 13.0 0.1 2.5 3 0 0 3 3 3 2 tRNA synthetases class I (M) DALR_2 PF09190.11 CCF40842.1 - 0.012 16.1 0.2 0.03 14.8 0.2 1.7 1 0 0 1 1 1 0 DALR domain tRNA-synt_1c PF00749.21 CCF40842.1 - 0.067 12.1 0.0 0.13 11.1 0.0 1.4 1 0 0 1 1 1 0 tRNA synthetases class I (E and Q), catalytic domain DUF1599 PF07659.11 CCF40842.1 - 0.15 12.5 0.3 0.47 11.0 0.1 1.9 2 0 0 2 2 2 0 Nucleotide modification associated domain 1 GCD14 PF08704.10 CCF40843.1 - 7.2e-56 189.6 0.0 7.1e-41 140.5 0.0 2.2 2 0 0 2 2 2 2 tRNA methyltransferase complex GCD14 subunit Myb_DNA-binding PF00249.31 CCF40844.1 - 0.0004 20.5 0.0 0.29 11.4 0.0 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Ketoacyl-synt_C PF02801.22 CCF40845.1 - 1.8e-36 124.8 0.0 3.6e-36 123.8 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain ketoacyl-synt PF00109.26 CCF40845.1 - 2.6e-26 92.7 0.3 3.2e-12 46.6 0.1 2.2 1 1 1 2 2 2 2 Beta-ketoacyl synthase, N-terminal domain KAsynt_C_assoc PF16197.5 CCF40845.1 - 7.4e-08 32.8 0.0 1.6e-07 31.7 0.0 1.6 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension ICMT PF04140.14 CCF40848.1 - 9.7e-05 22.7 0.0 0.00022 21.6 0.0 1.6 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 CCF40848.1 - 0.00017 22.0 0.0 0.00065 20.1 0.0 1.9 2 0 0 2 2 2 1 Phospholipid methyltransferase DUF2985 PF11204.8 CCF40849.1 - 1.6e-37 127.5 0.4 1.6e-37 127.5 0.4 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF2985) Phage_holin_3_6 PF07332.11 CCF40849.1 - 0.61 10.1 2.3 1.7 8.7 0.3 2.1 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Cu_bind_like PF02298.17 CCF40850.1 - 0.0022 18.0 0.0 0.0058 16.6 0.0 1.6 1 1 0 1 1 1 1 Plastocyanin-like domain DUF4449 PF14613.6 CCF40851.1 - 0.0007 19.7 0.0 0.0032 17.6 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF4449) Ntox35 PF15534.6 CCF40851.1 - 0.13 12.7 0.0 11 6.6 0.0 2.4 2 0 0 2 2 2 0 Bacterial toxin 35 LBP_BPI_CETP PF01273.25 CCF40851.1 - 0.14 11.8 0.0 0.28 10.8 0.0 1.5 1 0 0 1 1 1 0 LBP / BPI / CETP family, N-terminal domain DUF445 PF04286.12 CCF40851.1 - 0.3 10.9 2.4 1.6 8.5 2.4 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF445) PHD PF00628.29 CCF40852.1 - 1.2e-08 34.7 8.6 2.4e-08 33.7 8.6 1.5 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 CCF40852.1 - 0.011 15.2 5.2 0.024 14.2 5.2 1.5 1 0 0 1 1 1 0 PHD-finger Mem_trans PF03547.18 CCF40852.1 - 0.31 9.4 1.3 0.35 9.2 1.3 1.2 1 0 0 1 1 1 0 Membrane transport protein Ion_trans PF00520.31 CCF40853.1 - 1.3e-124 414.3 78.4 5.6e-42 143.7 12.6 4.7 4 1 0 4 4 4 4 Ion transport protein PKD_channel PF08016.12 CCF40853.1 - 0.0016 17.2 0.8 0.0016 17.2 0.8 7.0 6 1 1 7 7 7 5 Polycystin cation channel JSRP PF15312.6 CCF40853.1 - 0.054 13.4 0.0 0.21 11.5 0.0 2.0 1 0 0 1 1 1 0 Junctional sarcoplasmic reticulum protein Histidinol_dh PF00815.20 CCF40854.1 - 5e-160 533.0 4.8 6.6e-160 532.6 4.8 1.2 1 0 0 1 1 1 1 Histidinol dehydrogenase PRA-CH PF01502.18 CCF40854.1 - 1.2e-24 85.9 0.0 2.4e-24 84.9 0.0 1.5 1 0 0 1 1 1 1 Phosphoribosyl-AMP cyclohydrolase PRA-PH PF01503.17 CCF40854.1 - 1e-13 51.5 1.0 1.7e-13 50.8 0.2 1.8 2 0 0 2 2 2 1 Phosphoribosyl-ATP pyrophosphohydrolase Phasin_2 PF09361.10 CCF40854.1 - 0.0043 17.3 0.6 0.44 10.8 0.3 3.3 2 0 0 2 2 2 1 Phasin protein Seryl_tRNA_N PF02403.22 CCF40854.1 - 0.41 10.9 1.8 9 6.6 0.1 2.8 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Peptidase_M16 PF00675.20 CCF40855.1 - 8.5e-57 191.3 0.4 2.9e-56 189.6 0.5 1.9 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 CCF40855.1 - 3.9e-37 128.0 0.0 2.7e-36 125.3 0.0 2.1 2 0 0 2 2 2 1 Peptidase M16 inactive domain Esterase PF00756.20 CCF40855.1 - 0.0015 18.2 0.0 0.0031 17.2 0.0 1.5 1 0 0 1 1 1 1 Putative esterase Raffinose_syn PF05691.12 CCF40856.1 - 3e-55 187.3 1.7 7.3e-51 172.9 1.5 3.1 2 1 0 2 2 2 2 Raffinose synthase or seed imbibition protein Sip1 Pribosyltran PF00156.27 CCF40857.1 - 8.4e-15 54.6 0.0 1.4e-14 54.0 0.0 1.4 1 1 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 CCF40857.1 - 0.0017 17.9 0.0 0.0025 17.3 0.0 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pex2_Pex12 PF04757.14 CCF40859.1 - 2.3e-37 128.8 1.3 3.4e-37 128.2 1.3 1.2 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_4 PF15227.6 CCF40859.1 - 0.0013 18.9 3.9 0.0027 17.8 3.9 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 CCF40859.1 - 0.053 13.6 1.9 0.16 12.0 1.9 1.8 1 1 0 1 1 1 0 RING-type zinc-finger zf-C3HC4 PF00097.25 CCF40859.1 - 0.19 11.6 2.7 0.47 10.4 2.7 1.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CCF40859.1 - 0.83 9.6 3.9 0.45 10.4 0.7 2.1 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) TFIID_30kDa PF03540.13 CCF40861.1 - 1.5e-25 88.9 0.3 2.3e-25 88.3 0.3 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit FoP_duplication PF13865.6 CCF40861.1 - 0.12 12.9 0.4 0.25 11.9 0.4 1.5 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 Ribosomal_S19 PF00203.21 CCF40862.1 - 3.8e-28 97.2 0.0 4.5e-28 97.0 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S19 CSD2 PF17876.1 CCF40864.1 - 0.057 13.6 0.1 0.15 12.3 0.1 1.7 1 0 0 1 1 1 0 Cold shock domain Macoilin PF09726.9 CCF40864.1 - 2.8 6.4 8.8 3.4 6.1 8.8 1.0 1 0 0 1 1 1 0 Macoilin family DUF3433 PF11915.8 CCF40865.1 - 1.4e-08 35.1 1.1 3.4e-08 33.8 1.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3433) DUF805 PF05656.14 CCF40866.1 - 1.4 9.3 14.4 2.1 8.8 7.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF805) DUF423 PF04241.15 CCF40867.1 - 1.6 9.0 5.1 0.56 10.5 0.6 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF423) zf-FPG_IleRS PF06827.14 CCF40868.1 - 0.0014 18.5 0.3 0.08 12.8 0.1 2.3 2 0 0 2 2 2 1 Zinc finger found in FPG and IleRS Mut7-C PF01927.16 CCF40868.1 - 0.056 13.5 0.1 0.057 13.5 0.1 1.1 1 0 0 1 1 1 0 Mut7-C RNAse domain DUF1660 PF07874.11 CCF40868.1 - 0.07 13.6 2.0 3.7 8.1 0.0 2.3 1 1 1 2 2 2 0 Prophage protein (DUF1660) zinc_ribbon_9 PF14369.6 CCF40868.1 - 0.11 12.8 3.2 2.3 8.5 0.2 2.5 2 0 0 2 2 2 0 zinc-ribbon PalH PF08733.10 CCF40869.1 - 3.5e-109 364.8 1.2 4.5e-109 364.5 1.2 1.0 1 0 0 1 1 1 1 PalH/RIM21 CAAD PF14159.6 CCF40869.1 - 0.031 14.1 0.5 0.11 12.4 0.1 2.0 2 0 0 2 2 2 0 CAAD domains of cyanobacterial aminoacyl-tRNA synthetase Cation_ATPase_C PF00689.21 CCF40869.1 - 6.8 6.4 9.7 2.9 7.6 6.1 2.1 2 0 0 2 2 2 0 Cation transporting ATPase, C-terminus MARVEL PF01284.23 CCF40870.1 - 1e-09 38.6 12.3 1e-09 38.6 12.3 2.1 1 1 1 2 2 2 1 Membrane-associating domain ADH_zinc_N PF00107.26 CCF40871.1 - 0.00016 21.7 0.0 0.00025 21.0 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Asp PF00026.23 CCF40872.1 - 2.7e-108 362.1 0.1 3.8e-108 361.6 0.1 1.2 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCF40872.1 - 8.9e-16 58.6 0.6 2.6e-13 50.6 0.6 2.4 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 CCF40872.1 - 2.6e-05 24.8 0.0 0.24 12.0 0.0 3.3 2 2 1 3 3 3 2 Aspartyl protease gag-asp_proteas PF13975.6 CCF40872.1 - 0.00026 21.5 0.0 0.54 10.9 0.0 2.9 2 0 0 2 2 2 2 gag-polyprotein putative aspartyl protease TAXi_C PF14541.6 CCF40872.1 - 0.0021 17.9 0.0 0.014 15.2 0.0 2.2 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal DUF3039 PF11238.8 CCF40873.1 - 6.9 6.5 13.1 1.9 8.3 0.3 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3039) Ank_4 PF13637.6 CCF40876.1 - 2e-30 104.8 3.5 1.6e-08 34.9 0.0 6.5 5 2 2 7 7 7 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 CCF40876.1 - 3.6e-30 104.4 2.0 6.3e-10 39.5 0.0 4.2 3 1 1 4 4 4 3 Ankyrin repeats (3 copies) SPX PF03105.19 CCF40876.1 - 5.1e-20 72.7 16.9 1.9e-09 38.0 0.8 3.2 1 1 2 3 3 3 3 SPX domain Ank_3 PF13606.6 CCF40876.1 - 2.9e-19 67.1 7.4 0.00023 21.4 0.0 7.7 9 0 0 9 9 9 4 Ankyrin repeat Ank_5 PF13857.6 CCF40876.1 - 7.1e-18 64.4 9.0 0.00059 20.1 0.1 6.8 1 1 6 7 7 7 6 Ankyrin repeats (many copies) Ank PF00023.30 CCF40876.1 - 1.1e-13 50.9 8.3 0.00023 21.4 0.0 7.5 8 0 0 8 8 8 3 Ankyrin repeat GDPD PF03009.17 CCF40876.1 - 2.7e-07 30.6 0.0 1.2e-06 28.5 0.0 2.0 2 0 0 2 2 2 1 Glycerophosphoryl diester phosphodiesterase family RVP PF00077.20 CCF40876.1 - 0.011 16.0 0.0 0.032 14.6 0.0 1.7 1 0 0 1 1 1 0 Retroviral aspartyl protease MHC_I_C PF06623.11 CCF40876.1 - 0.15 12.0 3.6 0.33 10.9 3.6 1.5 1 0 0 1 1 1 0 MHC_I C-terminus Herpes_pp85 PF04637.12 CCF40877.1 - 1.5 7.2 10.3 2 6.7 10.3 1.1 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) SR-25 PF10500.9 CCF40877.1 - 2.7 7.5 12.6 3.7 7.1 12.6 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Coa1 PF08695.10 CCF40878.1 - 4.9e-29 100.5 0.6 1.2e-24 86.3 0.0 2.1 1 1 1 2 2 2 2 Cytochrome oxidase complex assembly protein 1 Class_IIIsignal PF04021.12 CCF40878.1 - 7.5 6.7 5.8 0.73 9.9 1.1 1.8 2 0 0 2 2 2 0 Class III signal peptide Ribosomal_L3 PF00297.22 CCF40879.1 - 3.5e-17 62.4 2.8 2.1e-12 46.7 0.8 2.0 1 1 1 2 2 2 2 Ribosomal protein L3 NAD_synthase PF02540.17 CCF40880.1 - 1.2e-22 80.3 0.0 3.2e-22 78.9 0.0 1.7 1 1 0 1 1 1 1 NAD synthase CN_hydrolase PF00795.22 CCF40880.1 - 2.1e-11 43.6 0.0 3.2e-11 43.1 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Asn_synthase PF00733.21 CCF40880.1 - 0.00015 21.6 0.1 0.00028 20.7 0.1 1.4 1 0 0 1 1 1 1 Asparagine synthase Na_Ca_ex PF01699.24 CCF40881.1 - 2.9e-38 131.2 40.0 4.4e-19 68.9 20.1 2.2 2 0 0 2 2 2 2 Sodium/calcium exchanger protein DUF3087 PF11286.8 CCF40881.1 - 0.17 11.4 0.4 0.45 10.0 0.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3087) Cation_ATPase_C PF00689.21 CCF40882.1 - 1.4e-26 93.3 13.5 3.1e-26 92.2 13.5 1.6 1 1 0 1 1 1 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 CCF40882.1 - 2.1e-19 70.6 0.0 7e-15 55.9 0.0 2.5 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CCF40882.1 - 1.7e-15 56.9 0.0 3.2e-15 56.0 0.0 1.4 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 CCF40882.1 - 0.00018 21.3 0.1 0.00046 20.0 0.2 1.6 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF4462 PF14692.6 CCF40882.1 - 0.28 10.7 0.9 0.61 9.6 0.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4462) YecR PF13992.6 CCF40883.1 - 0.021 15.1 0.0 1.1 9.6 0.0 2.4 2 0 0 2 2 2 0 YecR-like lipoprotein FAM70 PF14967.6 CCF40883.1 - 1.4 8.3 5.4 2 7.8 5.4 1.2 1 0 0 1 1 1 0 FAM70 protein Glyco_hydro_76 PF03663.14 CCF40884.1 - 2e-63 215.1 5.0 2.4e-63 214.9 5.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 GMC_oxred_N PF00732.19 CCF40885.1 - 0.00081 18.9 0.0 0.001 18.5 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase Thi4 PF01946.17 CCF40885.1 - 0.0019 17.5 0.0 0.0025 17.1 0.0 1.2 1 0 0 1 1 1 1 Thi4 family NAD_binding_8 PF13450.6 CCF40885.1 - 0.0024 18.0 0.1 0.0036 17.5 0.1 1.3 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 CCF40885.1 - 0.037 13.1 0.0 0.045 12.8 0.0 1.1 1 0 0 1 1 1 0 Lycopene cyclase protein DAO PF01266.24 CCF40885.1 - 0.046 13.3 0.0 0.055 13.0 0.0 1.1 1 0 0 1 1 1 0 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 CCF40885.1 - 0.048 13.6 0.1 0.067 13.2 0.1 1.2 1 0 0 1 1 1 0 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 CCF40885.1 - 0.11 11.5 0.1 0.14 11.2 0.1 1.1 1 0 0 1 1 1 0 FAD binding domain Pyr_redox_2 PF07992.14 CCF40885.1 - 0.12 11.6 0.0 0.16 11.2 0.0 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CCF40885.1 - 0.19 10.4 0.0 0.22 10.2 0.0 1.1 1 0 0 1 1 1 0 HI0933-like protein Fungal_trans PF04082.18 CCF40886.1 - 7.6e-12 44.8 0.6 1.2e-11 44.2 0.6 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 CCF40886.1 - 4.6e-09 36.2 14.3 0.00058 20.2 1.4 3.2 2 0 0 2 2 2 2 Zinc finger, C2H2 type Zn_clus PF00172.18 CCF40886.1 - 5.6e-06 26.4 12.1 5.6e-06 26.4 12.1 2.4 2 1 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-H2C2_2 PF13465.6 CCF40886.1 - 3.2e-05 24.2 3.2 3.2e-05 24.2 3.2 2.7 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_6 PF13912.6 CCF40886.1 - 0.00063 19.7 6.6 0.0065 16.5 1.9 2.6 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_4 PF13894.6 CCF40886.1 - 0.028 15.3 21.5 0.047 14.5 0.6 3.8 4 0 0 4 4 4 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CCF40886.1 - 0.053 13.8 2.4 1.4 9.2 0.6 2.6 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Acyl_transf_3 PF01757.22 CCF40887.1 - 7.3e-43 146.9 32.4 9.7e-43 146.5 32.4 1.2 1 0 0 1 1 1 1 Acyltransferase family DUF1749 PF08538.10 CCF40890.1 - 2.6e-87 292.7 0.0 3e-87 292.5 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1749) Abhydrolase_1 PF00561.20 CCF40890.1 - 2.5e-07 30.6 0.1 3.8e-06 26.7 0.0 2.1 1 1 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCF40890.1 - 9.4e-07 29.7 0.0 1.2e-06 29.3 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCF40890.1 - 3.4e-06 26.5 0.0 2.8e-05 23.5 0.0 2.0 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 CCF40890.1 - 0.00022 20.8 0.0 0.56 9.6 0.0 3.2 2 1 1 3 3 3 2 Prolyl oligopeptidase family Ndr PF03096.14 CCF40890.1 - 0.0061 15.3 0.0 0.0084 14.8 0.0 1.1 1 0 0 1 1 1 1 Ndr family Ser_hydrolase PF06821.13 CCF40890.1 - 0.012 15.5 0.0 0.024 14.5 0.0 1.6 1 1 0 1 1 1 0 Serine hydrolase Suc_Fer-like PF06999.12 CCF40892.1 - 2.2e-58 197.4 0.0 2.7e-58 197.1 0.0 1.1 1 0 0 1 1 1 1 Sucrase/ferredoxin-like Pkinase PF00069.25 CCF40893.1 - 8.1e-65 218.8 0.0 1.1e-64 218.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF40893.1 - 7.3e-40 136.9 0.0 9.4e-40 136.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF40893.1 - 0.00011 21.6 0.0 0.00023 20.6 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 CCF40893.1 - 0.00017 20.5 0.0 0.00026 19.9 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 CCF40893.1 - 0.037 13.0 0.0 0.05 12.5 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Seadorna_VP7 PF07387.11 CCF40893.1 - 0.074 12.1 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 HAD_2 PF13419.6 CCF40894.1 - 1.2e-13 51.5 0.0 7.6e-08 32.6 0.0 2.2 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CCF40894.1 - 1.2e-10 42.0 0.0 6e-06 26.7 0.0 2.5 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CCF40894.1 - 1.7e-06 28.0 0.1 4.3e-06 26.7 0.1 1.7 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 CCF40894.1 - 9.6e-05 22.9 0.0 0.00043 20.7 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase PGP_phosphatase PF09419.10 CCF40894.1 - 0.0013 18.4 0.0 0.53 9.9 0.0 2.3 2 0 0 2 2 2 2 Mitochondrial PGP phosphatase FUSC_2 PF13515.6 CCF40895.1 - 3.4e-26 91.8 9.8 3.4e-26 91.8 9.8 2.9 2 1 1 3 3 3 1 Fusaric acid resistance protein-like FUSC PF04632.12 CCF40895.1 - 0.00012 20.8 0.6 0.00012 20.8 0.6 2.7 3 0 0 3 3 3 2 Fusaric acid resistance protein family ArAE_2 PF10334.9 CCF40895.1 - 0.003 17.4 0.0 0.0093 15.8 0.0 1.8 1 0 0 1 1 1 1 Aromatic acid exporter family member 2 FlxA PF14282.6 CCF40896.1 - 0.091 12.8 0.1 0.23 11.4 0.1 1.6 1 0 0 1 1 1 0 FlxA-like protein Rer1 PF03248.13 CCF40897.1 - 3.5e-76 254.7 11.0 4e-76 254.5 11.0 1.0 1 0 0 1 1 1 1 Rer1 family ECH_1 PF00378.20 CCF40898.1 - 6.8e-77 258.2 0.0 7.8e-77 258.0 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CCF40898.1 - 5.2e-37 128.1 0.1 3.4e-36 125.4 0.1 1.9 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Thg1 PF04446.12 CCF40898.1 - 0.089 12.8 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 tRNAHis guanylyltransferase Lipocalin_9 PF17186.4 CCF40900.1 - 0.45 10.8 3.6 0.35 11.2 0.6 2.1 1 1 1 2 2 2 0 Lipocalin-like domain LRR_8 PF13855.6 CCF40901.1 - 2.7e-31 107.1 43.2 5.3e-07 29.3 1.6 8.1 6 2 3 9 9 9 8 Leucine rich repeat LRR_4 PF12799.7 CCF40901.1 - 3.1e-24 84.6 40.6 8.1e-05 22.9 3.8 9.5 3 3 7 11 11 11 9 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 CCF40901.1 - 0.0016 17.9 20.6 0.26 10.8 0.1 5.5 2 2 4 6 6 6 4 Leucine-rich repeat LRR_1 PF00560.33 CCF40901.1 - 0.0021 18.4 33.5 0.55 11.0 0.5 10.8 12 2 2 14 14 14 2 Leucine Rich Repeat LRR_6 PF13516.6 CCF40901.1 - 0.032 14.3 27.0 1.4 9.1 0.4 9.8 12 0 0 12 12 12 0 Leucine Rich repeat PK PF00224.21 CCF40902.1 - 6e-171 568.0 3.3 7.9e-171 567.6 3.3 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 CCF40902.1 - 5.1e-37 126.7 0.0 1.3e-36 125.4 0.0 1.7 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 CCF40902.1 - 0.00019 20.6 0.7 0.00065 18.9 0.3 2.0 1 1 1 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family IMPDH PF00478.25 CCF40902.1 - 0.069 12.1 0.0 1.3 8.0 0.0 2.2 2 0 0 2 2 2 0 IMP dehydrogenase / GMP reductase domain NAD_binding_1 PF00175.21 CCF40904.1 - 7.7e-33 113.4 0.0 1.8e-32 112.2 0.0 1.6 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 CCF40904.1 - 8.8e-24 83.7 0.0 1.5e-23 83.0 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 CCF40904.1 - 1.5e-09 38.1 0.0 6.9e-05 23.0 0.0 2.3 2 0 0 2 2 2 2 Ferric reductase NAD binding domain FAD_binding_9 PF08021.11 CCF40904.1 - 0.1 12.9 0.0 0.21 11.8 0.0 1.6 1 0 0 1 1 1 0 Siderophore-interacting FAD-binding domain Aminotran_4 PF01063.19 CCF40906.1 - 4.5e-09 36.5 0.0 5.2e-09 36.3 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV SAT PF16073.5 CCF40907.1 - 8.7e-35 120.6 0.1 1.3e-34 120.0 0.1 1.2 1 0 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis FAS_N PF17828.1 CCF40907.1 - 3e-11 43.4 0.0 5.3e-11 42.6 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain in fatty acid synthase subunit beta PhyH PF05721.13 CCF40908.1 - 7e-59 199.6 0.0 9e-59 199.3 0.0 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Claudin_2 PF13903.6 CCF40909.1 - 0.035 13.9 7.0 0.18 11.5 7.0 2.1 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction Benyvirus_P25 PF05744.11 CCF40909.1 - 0.11 11.8 0.3 0.58 9.4 0.0 1.9 2 0 0 2 2 2 0 Benyvirus P25/P26 protein CbiQ PF02361.16 CCF40909.1 - 1.8 8.2 8.6 0.049 13.2 1.8 1.7 2 0 0 2 2 2 0 Cobalt transport protein S1 PF00575.23 CCF40910.1 - 3.3e-71 235.6 29.0 2.1e-15 56.8 1.3 9.3 9 0 0 9 9 9 8 S1 RNA binding domain TPR_19 PF14559.6 CCF40910.1 - 4.4e-06 27.1 2.3 0.56 10.8 0.0 4.4 3 1 0 4 4 4 2 Tetratricopeptide repeat RNase_II_C_S1 PF18614.1 CCF40910.1 - 9.2e-06 25.5 5.7 4.7 7.2 0.0 6.6 6 0 0 6 6 6 1 RNase II-type exonuclease C-terminal S1 domain TPR_14 PF13428.6 CCF40910.1 - 2.6e-05 24.7 4.2 3.5 8.7 0.0 5.5 4 1 2 6 6 5 2 Tetratricopeptide repeat S1_2 PF13509.6 CCF40910.1 - 0.0001 22.3 0.6 7.8 6.6 0.0 4.8 4 0 0 4 4 4 1 S1 domain RNase_H2_suC PF08615.11 CCF40910.1 - 0.0013 18.9 0.0 0.0064 16.7 0.0 2.1 1 1 0 1 1 1 1 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) DUF2187 PF09953.9 CCF40910.1 - 0.0047 16.9 3.0 0.043 13.8 0.0 3.8 3 0 0 3 3 3 1 Uncharacterized protein conserved in bacteria (DUF2187) TPR_17 PF13431.6 CCF40910.1 - 0.0086 16.4 0.0 72 4.1 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat SDA1 PF05285.12 CCF40910.1 - 0.011 15.2 17.9 0.019 14.4 17.9 1.3 1 0 0 1 1 1 0 SDA1 TPR_16 PF13432.6 CCF40910.1 - 0.039 14.6 0.4 10 6.9 0.0 3.4 3 1 0 3 3 3 0 Tetratricopeptide repeat AEP1 PF17049.5 CCF40910.1 - 0.049 12.7 0.1 0.086 11.9 0.1 1.3 1 0 0 1 1 1 0 ATPase expression protein 1 TPR_6 PF13174.6 CCF40910.1 - 0.057 14.1 0.6 14 6.6 0.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat CDC45 PF02724.14 CCF40910.1 - 0.25 9.6 11.3 0.4 8.9 11.3 1.2 1 0 0 1 1 1 0 CDC45-like protein RNA_pol_Rbc25 PF08292.12 CCF40910.1 - 2.4 8.4 8.0 40 4.5 0.0 5.3 6 0 0 6 6 5 0 RNA polymerase III subunit Rpc25 Nop14 PF04147.12 CCF40910.1 - 4 5.5 19.5 5.8 5.0 19.5 1.1 1 0 0 1 1 1 0 Nop14-like family RRN3 PF05327.11 CCF40910.1 - 9 4.7 7.6 14 4.1 7.6 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 LsmAD PF06741.13 CCF40912.1 - 1.5e-28 99.2 0.9 1.5e-28 99.2 0.9 2.5 2 0 0 2 2 2 1 LsmAD domain Tantalus PF15386.6 CCF40912.1 - 0.0065 16.5 0.0 0.018 15.2 0.0 1.8 1 0 0 1 1 1 1 Drosophila Tantalus-like Peptidase_M16 PF00675.20 CCF40913.1 - 1.8e-16 60.4 0.1 3.4e-16 59.6 0.1 1.4 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 CCF40913.1 - 6.4e-12 45.9 0.0 1.2e-11 44.9 0.0 1.4 1 0 0 1 1 1 1 Peptidase M16 inactive domain HTH_9 PF08221.11 CCF40914.1 - 6.6e-11 42.2 0.3 1.4e-08 34.7 0.1 2.3 2 0 0 2 2 2 2 RNA polymerase III subunit RPC82 helix-turn-helix domain RNA_pol_Rpc82 PF05645.13 CCF40914.1 - 0.045 13.5 0.0 2.7 7.7 0.0 2.1 2 0 0 2 2 2 0 RNA polymerase III subunit RPC82 TFIIE_alpha PF02002.17 CCF40914.1 - 0.11 12.4 0.0 0.58 10.0 0.0 2.1 2 1 1 3 3 3 0 TFIIE alpha subunit FMO-like PF00743.19 CCF40917.1 - 1.2e-16 60.2 1.1 3.3e-14 52.2 0.9 2.8 1 1 1 2 2 2 2 Flavin-binding monooxygenase-like K_oxygenase PF13434.6 CCF40917.1 - 2e-09 37.1 0.0 1.6e-06 27.5 0.0 3.1 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 CCF40917.1 - 2.2e-07 31.0 0.0 5.4e-07 29.8 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 CCF40917.1 - 5.6e-06 25.8 0.0 6.7e-05 22.3 0.0 2.3 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CCF40917.1 - 2.4e-05 23.7 0.0 0.0057 15.9 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CCF40917.1 - 0.047 13.7 0.0 1.7 8.6 0.0 2.5 2 0 0 2 2 2 0 FAD-NAD(P)-binding VRR_NUC PF08774.11 CCF40917.1 - 0.062 13.4 0.0 8.7 6.5 0.0 2.6 2 0 0 2 2 2 0 VRR-NUC domain HTH_51 PF18558.1 CCF40918.1 - 4.1e-24 84.3 0.0 7.9e-24 83.4 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain Methyltransf_12 PF08242.12 CCF40918.1 - 6.1e-11 42.9 0.0 1.2e-10 41.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF40918.1 - 1.5e-07 31.4 0.0 2.7e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF40918.1 - 1.6e-07 32.0 0.0 3.4e-07 30.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PP-binding PF00550.25 CCF40918.1 - 2.2e-06 27.9 0.0 7.5e-06 26.2 0.0 2.0 1 0 0 1 1 1 1 Phosphopantetheine attachment site PS-DH PF14765.6 CCF40918.1 - 8.5e-05 21.9 0.0 0.00014 21.2 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Methyltransf_31 PF13847.6 CCF40918.1 - 0.00064 19.5 0.0 0.0013 18.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF40918.1 - 0.0029 18.2 0.0 0.0055 17.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.20 CCF40918.1 - 0.011 14.8 0.0 0.026 13.6 0.0 1.6 2 0 0 2 2 2 0 Ribosomal RNA adenine dimethylase Methyltransf_16 PF10294.9 CCF40918.1 - 0.045 13.5 0.0 0.079 12.7 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_33 PF10017.9 CCF40918.1 - 0.093 11.9 0.0 0.18 10.9 0.0 1.3 1 0 0 1 1 1 0 Histidine-specific methyltransferase, SAM-dependent Methyltransf_28 PF02636.17 CCF40918.1 - 0.11 12.1 0.0 0.2 11.2 0.0 1.4 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Dynamin_N PF00350.23 CCF40920.1 - 4.8e-44 150.4 0.0 8.9e-44 149.5 0.0 1.5 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 CCF40920.1 - 7.8e-12 45.0 0.0 3.3e-09 36.4 0.0 2.4 2 0 0 2 2 2 2 Dynamin central region MMR_HSR1 PF01926.23 CCF40920.1 - 3.1e-06 27.2 0.0 4.5e-05 23.5 0.0 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase DUF4872 PF16169.5 CCF40920.1 - 0.02 14.6 1.2 0.092 12.5 0.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4872) AAA_28 PF13521.6 CCF40920.1 - 0.032 14.5 0.0 0.097 12.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_21 PF13304.6 CCF40920.1 - 0.037 13.8 0.0 0.077 12.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 CCF40920.1 - 0.063 13.7 0.1 0.063 13.7 0.1 2.9 3 1 0 3 3 3 0 AAA ATPase domain AAA_15 PF13175.6 CCF40920.1 - 0.082 12.6 0.1 0.21 11.2 0.1 1.6 1 0 0 1 1 1 0 AAA ATPase domain Roc PF08477.13 CCF40920.1 - 0.12 12.5 0.0 0.46 10.7 0.0 2.0 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Ferric_reduct PF01794.19 CCF40922.1 - 1.5e-21 76.8 14.0 1.5e-21 76.8 14.0 2.6 2 1 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 CCF40922.1 - 1.4e-10 41.2 0.0 3.3e-10 40.0 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 CCF40922.1 - 9.3e-06 25.8 0.0 1.5e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain DUF4405 PF14358.6 CCF40922.1 - 0.026 15.1 17.1 0.061 13.9 3.5 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4405) DUF2075 PF09848.9 CCF40922.1 - 0.047 12.9 0.0 0.06 12.6 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Cupin_1 PF00190.22 CCF40923.1 - 5.8e-39 133.1 0.0 5.9e-20 71.4 0.0 2.1 2 0 0 2 2 2 2 Cupin Cupin_2 PF07883.11 CCF40923.1 - 2.7e-27 94.3 0.7 4.6e-13 48.7 0.1 2.3 2 0 0 2 2 2 2 Cupin domain Cupin_3 PF05899.12 CCF40923.1 - 4e-09 36.1 0.0 0.00019 21.1 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF861) AraC_binding PF02311.19 CCF40923.1 - 8.2e-08 32.2 0.2 0.00026 20.9 0.0 2.4 2 0 0 2 2 2 2 AraC-like ligand binding domain MannoseP_isomer PF01050.18 CCF40923.1 - 0.00013 21.9 0.0 0.013 15.4 0.0 2.2 2 0 0 2 2 2 1 Mannose-6-phosphate isomerase 3-HAO PF06052.12 CCF40923.1 - 0.0043 16.7 0.0 0.059 13.0 0.0 2.1 2 0 0 2 2 2 1 3-hydroxyanthranilic acid dioxygenase ARD PF03079.14 CCF40923.1 - 0.069 13.3 3.0 5 7.3 0.0 2.5 3 0 0 3 3 3 0 ARD/ARD' family Cupin_7 PF12973.7 CCF40923.1 - 0.079 12.9 0.9 0.98 9.4 0.1 2.9 3 1 0 3 3 3 0 ChrR Cupin-like domain DUF3140 PF11338.8 CCF40924.1 - 7.5e-34 116.0 1.6 7.5e-34 116.0 1.6 3.5 2 1 1 3 3 3 1 Protein of unknown function (DUF3140) Hva1_TUDOR PF11160.8 CCF40924.1 - 1.3e-13 50.9 2.2 1.3e-13 50.9 2.2 3.3 3 0 0 3 3 3 1 Hypervirulence associated proteins TUDOR domain Mitofilin PF09731.9 CCF40924.1 - 0.58 8.9 27.2 0.72 8.6 27.2 1.2 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Sec8_exocyst PF04048.14 CCF40926.1 - 5.1e-47 159.3 0.2 1.4e-46 157.9 0.2 1.9 1 0 0 1 1 1 1 Sec8 exocyst complex component specific domain Vps54_N PF10475.9 CCF40926.1 - 3.1e-08 33.3 0.4 5.6e-08 32.4 0.4 1.4 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex DUF1759 PF03564.15 CCF40926.1 - 0.13 12.2 0.5 2 8.4 0.1 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1759) Mannosyl_trans2 PF04188.13 CCF40928.1 - 4.9e-62 210.7 2.4 5.9e-62 210.4 2.4 1.0 1 0 0 1 1 1 1 Mannosyltransferase (PIG-V) PMT PF02366.18 CCF40928.1 - 0.45 10.1 9.8 0.071 12.7 4.8 2.1 2 1 0 2 2 2 0 Dolichyl-phosphate-mannose-protein mannosyltransferase MFAP1 PF06991.11 CCF40929.1 - 2.3e-35 122.4 12.8 2.3e-35 122.4 12.8 1.9 2 0 0 2 2 2 1 Microfibril-associated/Pre-mRNA processing Pol_alpha_B_N PF08418.10 CCF40930.1 - 5.2e-89 298.4 0.5 6.6e-89 298.1 0.5 1.1 1 0 0 1 1 1 1 DNA polymerase alpha subunit B N-terminal DNA_pol_E_B PF04042.16 CCF40930.1 - 4.4e-43 147.1 0.2 6.1e-43 146.6 0.2 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B NMO PF03060.15 CCF40931.1 - 8e-49 166.8 0.1 1.1e-48 166.3 0.1 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 CCF40931.1 - 7.9e-08 31.7 0.1 3.3e-06 26.3 0.0 2.5 2 1 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 CCF40931.1 - 0.0046 16.0 2.1 0.0078 15.3 2.1 1.3 1 0 0 1 1 1 1 FMN-dependent dehydrogenase zf-C2H2_4 PF13894.6 CCF40933.1 - 2.3e-14 52.8 14.9 0.007 17.1 0.1 5.5 5 0 0 5 5 5 5 C2H2-type zinc finger zf-C2H2 PF00096.26 CCF40933.1 - 8.7e-13 48.0 17.0 0.016 15.6 0.4 5.5 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 CCF40933.1 - 6.1e-08 32.5 11.3 0.00011 22.1 0.1 4.9 5 0 0 5 5 5 2 C2H2-type zinc finger zf-C2H2_8 PF15909.5 CCF40933.1 - 1.4e-07 31.8 8.6 0.00017 21.8 0.7 2.9 2 1 0 3 3 3 2 C2H2-type zinc ribbon zf-H2C2_2 PF13465.6 CCF40933.1 - 0.00014 22.2 16.0 0.032 14.7 0.2 5.3 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2_9 PF16293.5 CCF40933.1 - 0.00049 19.9 10.8 0.19 11.6 0.1 5.1 2 2 3 5 5 5 1 C2H2 type zinc-finger (1 copy) zf-C2H2_jaz PF12171.8 CCF40933.1 - 0.0051 17.1 4.8 23 5.4 0.0 4.7 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 CCF40933.1 - 0.0077 16.5 16.6 0.75 10.1 5.6 3.5 2 1 1 3 3 3 3 Drought induced 19 protein (Di19), zinc-binding Trm112p PF03966.16 CCF40933.1 - 0.01 16.4 1.1 0.38 11.4 0.4 2.9 2 1 0 2 2 2 0 Trm112p-like protein Zn-ribbon_8 PF09723.10 CCF40933.1 - 0.032 14.3 8.8 3.4 7.9 0.3 3.6 3 0 0 3 3 3 0 Zinc ribbon domain zf-C2H2_aberr PF17017.5 CCF40933.1 - 0.048 13.8 4.8 0.58 10.3 0.2 2.6 2 1 0 2 2 2 0 Aberrant zinc-finger zf-C2H2_2 PF12756.7 CCF40933.1 - 0.049 14.0 17.1 6.8 7.1 2.0 4.9 2 2 1 3 3 3 0 C2H2 type zinc-finger (2 copies) FOXP-CC PF16159.5 CCF40933.1 - 0.14 12.8 5.4 21 5.8 0.0 4.2 2 2 1 4 4 4 0 FOXP coiled-coil domain zinc-ribbons_6 PF07191.12 CCF40933.1 - 0.81 9.7 9.2 39 4.3 0.2 3.9 2 1 1 3 3 3 0 zinc-ribbons zinc_ribbon_9 PF14369.6 CCF40933.1 - 1.8 8.9 0.0 1.8 8.9 0.0 3.2 4 0 0 4 4 4 0 zinc-ribbon zf-C2H2_12 PF18658.1 CCF40933.1 - 1.9 8.1 7.1 2.1 8.0 2.8 2.7 1 1 1 2 2 2 0 Zinc-finger C2H2-type zf-C2H2_3rep PF18868.1 CCF40933.1 - 2.3 8.9 7.7 12 6.6 1.6 3.3 3 2 0 3 3 3 0 Zinc finger C2H2-type, 3 repeats zf-NADH-PPase PF09297.11 CCF40933.1 - 4.8 6.9 8.8 26 4.6 0.1 4.2 4 0 0 4 4 4 0 NADH pyrophosphatase zinc ribbon domain Taxilin PF09728.9 CCF40935.1 - 2.9e-46 158.0 29.9 3.4e-46 157.9 29.9 1.0 1 0 0 1 1 1 1 Myosin-like coiled-coil protein DHR10 PF18595.1 CCF40935.1 - 0.0023 18.0 21.5 0.0023 18.0 21.5 1.7 1 1 0 1 1 1 1 Designed helical repeat protein 10 domain Cep57_CLD_2 PF14197.6 CCF40935.1 - 0.0072 16.4 2.2 0.0072 16.4 2.2 2.5 2 0 0 2 2 2 1 Centrosome localisation domain of PPC89 DUF4810 PF16068.5 CCF40935.1 - 0.013 16.1 0.0 0.013 16.1 0.0 3.1 2 1 2 4 4 4 0 Domain of unknown function (DUF4810) DUF4201 PF13870.6 CCF40935.1 - 0.026 14.2 19.1 1 9.1 18.6 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4201) Laminin_I PF06008.14 CCF40935.1 - 0.039 13.7 18.1 0.1 12.3 10.3 2.1 1 1 1 2 2 2 0 Laminin Domain I IFT57 PF10498.9 CCF40935.1 - 0.15 11.0 18.3 0.047 12.7 8.3 2.4 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 Tn7_Tnp_TnsA_C PF08721.11 CCF40935.1 - 0.16 12.6 1.8 3.7 8.3 0.1 2.6 2 1 0 2 2 2 0 TnsA endonuclease C terminal Jnk-SapK_ap_N PF09744.9 CCF40935.1 - 0.24 11.6 23.5 0.93 9.7 22.8 2.0 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 DUF4239 PF14023.6 CCF40935.1 - 0.31 10.7 8.3 0.41 10.3 8.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4239) DUF724 PF05266.14 CCF40935.1 - 0.4 10.5 17.4 0.024 14.4 9.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF724) KASH_CCD PF14662.6 CCF40935.1 - 0.42 10.4 18.2 1.1 9.0 18.0 1.7 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH PRKG1_interact PF15898.5 CCF40935.1 - 0.46 11.4 18.7 2.9 8.8 13.6 2.4 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain MAD PF05557.13 CCF40935.1 - 0.51 8.6 21.6 0.61 8.4 21.6 1.0 1 0 0 1 1 1 0 Mitotic checkpoint protein BLOC1_2 PF10046.9 CCF40935.1 - 0.68 10.3 13.9 1.1 9.6 5.1 2.5 1 1 2 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 RmuC PF02646.16 CCF40935.1 - 0.82 8.7 15.6 0.8 8.8 5.4 2.4 1 1 2 3 3 3 0 RmuC family Spc7 PF08317.11 CCF40935.1 - 0.84 8.5 18.3 1.1 8.0 18.3 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein YabA PF06156.13 CCF40935.1 - 1.1 10.0 12.0 0.32 11.7 6.9 2.3 1 1 1 2 2 2 0 Initiation control protein YabA LMBR1 PF04791.16 CCF40935.1 - 1.1 8.1 11.8 1.3 7.8 11.8 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Sec20 PF03908.13 CCF40935.1 - 1.4 8.9 8.0 0.46 10.4 2.5 2.4 1 1 2 3 3 3 0 Sec20 APC_N_CC PF16689.5 CCF40935.1 - 1.4 9.0 10.8 0.36 10.9 4.1 2.5 1 1 1 2 2 2 0 Coiled-coil N-terminus of APC, dimerisation domain WXG100 PF06013.12 CCF40935.1 - 2 8.7 9.8 12 6.2 0.5 3.3 1 1 2 3 3 3 0 Proteins of 100 residues with WXG TMPIT PF07851.13 CCF40935.1 - 2.4 7.3 15.4 1.7 7.8 7.0 2.0 1 1 1 2 2 2 0 TMPIT-like protein CENP-F_leu_zip PF10473.9 CCF40935.1 - 2.6 8.1 25.5 1.8 8.6 14.4 2.1 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Borrelia_P83 PF05262.11 CCF40935.1 - 3.3 6.1 18.6 0.052 12.0 9.3 1.9 1 1 1 2 2 2 0 Borrelia P83/100 protein GAS PF13851.6 CCF40935.1 - 3.3 7.0 26.4 1.2 8.4 13.9 2.1 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DUF4611 PF15387.6 CCF40935.1 - 3.5 7.9 9.4 0.27 11.5 3.8 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4611) Laminin_II PF06009.12 CCF40935.1 - 4 7.5 13.9 5.9 6.9 6.3 2.1 1 1 1 2 2 2 0 Laminin Domain II DUF948 PF06103.11 CCF40935.1 - 4.1 7.7 8.8 7.1 7.0 4.3 2.5 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) ERM PF00769.19 CCF40935.1 - 4.1 7.1 30.3 98 2.6 30.3 2.1 1 1 0 1 1 1 0 Ezrin/radixin/moesin family DUF3810 PF12725.7 CCF40935.1 - 4.2 6.6 7.1 1.8 7.8 4.5 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3810) DUF1664 PF07889.12 CCF40935.1 - 4.5 7.3 11.2 5.1 7.2 6.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Prominin PF05478.11 CCF40935.1 - 4.9 5.0 7.7 6.6 4.6 7.7 1.2 1 0 0 1 1 1 0 Prominin UPF0242 PF06785.11 CCF40935.1 - 5 7.2 20.0 9 6.3 20.0 1.4 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF4200 PF13863.6 CCF40935.1 - 5.5 7.4 30.2 5.7 7.4 5.5 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) FliD_N PF02465.18 CCF40935.1 - 6.2 7.6 14.3 5.3e+02 1.4 11.4 2.7 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 N-terminus Exonuc_VII_L PF02601.15 CCF40935.1 - 6.2 6.3 12.5 8.4 5.9 12.5 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit KxDL PF10241.9 CCF40935.1 - 6.7 7.1 13.2 0.97 9.7 7.0 2.2 1 1 1 2 2 2 0 Uncharacterized conserved protein DUF2203 PF09969.9 CCF40935.1 - 8.5 7.1 14.9 3.9 8.2 6.3 2.2 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) FAM76 PF16046.5 CCF40935.1 - 8.8 5.6 15.6 12 5.2 15.6 1.1 1 0 0 1 1 1 0 FAM76 protein BRE1 PF08647.11 CCF40935.1 - 9.6 6.4 24.0 0.65 10.1 10.7 2.2 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase Ribosomal_S27e PF01667.17 CCF40936.1 - 0.012 15.3 0.1 1.8 8.3 0.1 2.5 2 0 0 2 2 2 0 Ribosomal protein S27 zinc_ribbon_4 PF13717.6 CCF40936.1 - 0.037 13.9 5.2 0.16 11.9 0.6 2.7 3 0 0 3 3 3 0 zinc-ribbon domain zinc_ribbon_5 PF13719.6 CCF40936.1 - 0.64 9.8 5.9 11 5.9 4.9 2.5 1 1 1 2 2 2 0 zinc-ribbon domain Sugar_tr PF00083.24 CCF40937.1 - 5.5e-31 107.9 4.3 6e-31 107.8 4.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF40937.1 - 8.7e-13 47.9 11.1 1e-12 47.7 11.1 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 CCF40937.1 - 0.00043 19.7 2.3 0.00053 19.4 2.3 1.0 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB HlyIII PF03006.20 CCF40938.1 - 2.2e-31 109.4 4.7 2.7e-31 109.0 4.7 1.1 1 0 0 1 1 1 1 Haemolysin-III related TssN PF17555.2 CCF40938.1 - 0.004 16.6 0.2 0.0052 16.2 0.2 1.2 1 0 0 1 1 1 1 Type VI secretion system, TssN DUF962 PF06127.11 CCF40938.1 - 0.094 12.8 0.5 0.14 12.2 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF962) TMA7 PF09072.10 CCF40939.1 - 6.4e-26 91.0 18.6 7.2e-26 90.8 18.6 1.0 1 0 0 1 1 1 1 Translation machinery associated TMA7 MFS_1 PF07690.16 CCF40941.1 - 2.7e-38 131.8 35.2 2.7e-38 131.8 35.2 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 CCF40941.1 - 0.00057 18.4 5.0 0.00057 18.4 5.0 1.6 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Sacchrp_dh_C PF16653.5 CCF40942.1 - 3.3e-77 260.2 0.0 1.3e-76 258.2 0.0 1.8 1 1 0 1 1 1 1 Saccharopine dehydrogenase C-terminal domain Sacchrp_dh_NADP PF03435.18 CCF40942.1 - 3.8e-21 75.7 0.4 5.9e-21 75.1 0.4 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 CCF40942.1 - 1.7e-08 34.6 0.1 2.8e-08 33.9 0.1 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_10 PF13460.6 CCF40942.1 - 0.0069 16.3 0.2 0.01 15.8 0.2 1.2 1 0 0 1 1 1 1 NAD(P)H-binding F420_oxidored PF03807.17 CCF40942.1 - 0.05 14.2 0.0 0.1 13.2 0.0 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent TatD_DNase PF01026.21 CCF40943.1 - 1.1e-40 139.7 0.0 1.4e-40 139.3 0.0 1.1 1 0 0 1 1 1 1 TatD related DNase zf-C2H2 PF00096.26 CCF40944.1 - 0.027 14.9 5.8 1.1 9.8 1.0 2.7 2 0 0 2 2 2 0 Zinc finger, C2H2 type Inj_translocase PF16928.5 CCF40944.1 - 0.031 13.7 2.9 0.077 12.4 2.9 1.6 1 0 0 1 1 1 0 DNA/protein translocase of phage P22 injectosome zf-C2H2_4 PF13894.6 CCF40944.1 - 2.5 9.2 6.6 21 6.3 0.5 3.2 2 1 0 2 2 2 0 C2H2-type zinc finger DUF2464 PF10240.9 CCF40944.1 - 3 7.4 5.6 5 6.6 5.6 1.4 1 1 0 1 1 1 0 Multivesicular body subunit 12 SUIM_assoc PF16619.5 CCF40944.1 - 6.4 6.9 13.2 0.65 10.1 6.5 2.3 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Sterol-sensing PF12349.8 CCF40945.1 - 8.2e-38 129.6 10.0 1.4e-37 128.9 10.0 1.3 1 0 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.18 CCF40945.1 - 4.1e-11 41.7 2.8 5.7e-11 41.2 2.8 1.1 1 0 0 1 1 1 1 Patched family MMPL PF03176.15 CCF40945.1 - 0.0044 16.0 0.0 0.0098 14.9 0.0 1.5 1 0 0 1 1 1 1 MMPL family GAS PF13851.6 CCF40946.1 - 0.048 13.0 3.1 0.99 8.7 2.1 2.2 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DUF4051 PF13260.6 CCF40946.1 - 0.065 13.0 0.1 0.15 11.8 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4051) TMF_TATA_bd PF12325.8 CCF40946.1 - 0.18 12.1 8.6 0.69 10.1 0.1 3.3 2 1 0 3 3 3 0 TATA element modulatory factor 1 TATA binding CheZ PF04344.13 CCF40946.1 - 0.31 10.9 4.1 1.1 9.1 0.5 2.3 1 1 1 2 2 2 0 Chemotaxis phosphatase, CheZ Seryl_tRNA_N PF02403.22 CCF40946.1 - 1.9 8.8 6.0 0.57 10.4 0.7 2.8 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain COG2 PF06148.11 CCF40946.1 - 2.5 8.2 5.5 13 5.9 0.1 3.1 2 1 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 PspB PF06667.12 CCF40946.1 - 3.7 7.7 5.3 9.6 6.3 0.1 3.8 3 2 2 5 5 5 0 Phage shock protein B DnaJ PF00226.31 CCF40947.1 - 1.5e-21 76.3 2.3 5.3e-21 74.5 2.3 2.0 1 0 0 1 1 1 1 DnaJ domain TPR_2 PF07719.17 CCF40947.1 - 4.3e-16 57.6 0.3 0.1 12.8 0.0 8.0 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_1 PF00515.28 CCF40947.1 - 8.8e-16 57.0 0.0 0.0038 17.0 0.0 6.1 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_9 PF13371.6 CCF40947.1 - 1.6e-14 53.8 1.2 0.0012 18.9 0.0 4.8 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.6 CCF40947.1 - 1.8e-12 46.9 3.7 0.031 15.1 0.1 6.9 3 2 3 7 7 7 3 Tetratricopeptide repeat TPR_8 PF13181.6 CCF40947.1 - 1.3e-11 43.7 0.0 0.067 13.4 0.0 6.6 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_19 PF14559.6 CCF40947.1 - 1.6e-10 41.3 1.5 0.0069 16.9 0.2 4.8 3 1 2 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.6 CCF40947.1 - 4.7e-08 32.9 0.4 0.0032 17.7 0.1 4.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 CCF40947.1 - 1.2e-06 28.1 0.3 0.026 14.2 0.0 3.9 3 1 1 4 4 3 2 TPR repeat TPR_16 PF13432.6 CCF40947.1 - 3.6e-06 27.5 6.0 0.26 12.0 0.1 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat PknG_TPR PF16918.5 CCF40947.1 - 5e-06 25.5 0.4 0.0036 16.1 0.2 3.2 3 1 0 3 3 3 2 Protein kinase G tetratricopeptide repeat TPR_7 PF13176.6 CCF40947.1 - 1.5e-05 24.7 0.7 1 9.6 0.0 5.4 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 CCF40947.1 - 0.00016 22.1 9.8 3.3 8.5 0.0 7.9 9 0 0 9 9 9 1 Tetratricopeptide repeat TPR_12 PF13424.6 CCF40947.1 - 0.00049 20.3 3.3 0.67 10.3 0.2 5.4 5 2 1 6 6 6 1 Tetratricopeptide repeat ANAPC3 PF12895.7 CCF40947.1 - 0.0012 19.0 4.4 0.22 11.8 0.0 4.6 4 1 0 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.6 CCF40947.1 - 0.0014 17.9 4.9 9.3 5.4 0.0 4.9 3 2 2 5 5 5 1 Tetratricopeptide repeat TPR_20 PF14561.6 CCF40947.1 - 0.098 13.0 3.6 4.6 7.6 0.0 4.4 3 2 1 4 4 4 0 Tetratricopeptide repeat MA3 PF02847.17 CCF40947.1 - 0.23 11.4 0.7 0.84 9.6 0.0 2.2 3 0 0 3 3 3 0 MA3 domain UDPGT PF00201.18 CCF40949.1 - 0.00011 21.2 0.0 0.00015 20.7 0.0 1.2 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 CCF40949.1 - 0.0047 16.9 0.0 0.0084 16.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_transf_28 PF03033.20 CCF40949.1 - 0.085 12.9 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Glycosyltransferase family 28 N-terminal domain B12-binding PF02310.19 CCF40949.1 - 0.086 12.9 0.1 0.3 11.1 0.0 2.0 2 0 0 2 2 2 0 B12 binding domain AAA_19 PF13245.6 CCF40949.1 - 0.11 12.9 0.0 0.17 12.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain p450 PF00067.22 CCF40950.1 - 4.9e-49 167.3 0.0 7e-49 166.8 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 NTP_transf_5 PF14907.6 CCF40950.1 - 0.11 12.1 0.1 0.18 11.4 0.1 1.3 1 0 0 1 1 1 0 Uncharacterised nucleotidyltransferase adh_short_C2 PF13561.6 CCF40951.1 - 4.1e-40 137.8 0.3 9.4e-40 136.6 0.3 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF40951.1 - 2.1e-39 135.0 0.4 3.5e-39 134.3 0.4 1.4 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF40951.1 - 9.8e-07 28.8 2.2 9.8e-07 28.8 2.2 1.6 2 0 0 2 2 2 1 KR domain TrkA_N PF02254.18 CCF40951.1 - 0.0005 20.3 0.1 0.00085 19.6 0.1 1.3 1 0 0 1 1 1 1 TrkA-N domain Epimerase PF01370.21 CCF40951.1 - 0.00072 19.1 1.4 0.0022 17.5 0.4 2.1 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family ADH_zinc_N PF00107.26 CCF40951.1 - 0.0013 18.8 0.8 0.0026 17.8 0.8 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase NAD_binding_10 PF13460.6 CCF40951.1 - 0.0021 18.0 0.2 0.0058 16.5 0.1 1.7 2 0 0 2 2 2 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 CCF40951.1 - 0.0096 16.2 0.5 0.017 15.3 0.5 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain 3Beta_HSD PF01073.19 CCF40951.1 - 0.016 14.2 0.2 0.024 13.7 0.2 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 CCF40951.1 - 0.029 13.8 0.2 0.029 13.8 0.2 1.5 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase 3HCDH_N PF02737.18 CCF40951.1 - 0.043 13.7 1.8 0.068 13.0 1.8 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF3127 PF11325.8 CCF40951.1 - 0.051 13.8 0.0 0.11 12.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3127) p450 PF00067.22 CCF40952.1 - 7.2e-55 186.6 0.0 1e-54 186.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 adh_short PF00106.25 CCF40953.1 - 1.5e-16 60.5 0.0 8e-16 58.1 0.0 1.8 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF40953.1 - 1.1e-13 51.4 0.2 8.8e-13 48.4 0.2 2.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Lon_C PF05362.13 CCF40953.1 - 0.05 13.1 0.4 0.094 12.2 0.3 1.5 2 0 0 2 2 2 0 Lon protease (S16) C-terminal proteolytic domain NADHdh PF00146.21 CCF40953.1 - 0.21 10.8 0.0 0.28 10.5 0.0 1.1 1 0 0 1 1 1 0 NADH dehydrogenase Tox-REase-7 PF15649.6 CCF40954.1 - 0.087 13.1 0.1 0.14 12.5 0.1 1.4 1 0 0 1 1 1 0 Restriction endonuclease fold toxin 7 SPOR PF05036.13 CCF40958.1 - 0.037 14.4 0.1 0.045 14.1 0.1 1.2 1 0 0 1 1 1 0 Sporulation related domain COesterase PF00135.28 CCF40959.1 - 6.9e-34 117.6 0.0 1.1e-33 117.0 0.0 1.2 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CCF40959.1 - 0.0014 18.5 0.1 0.003 17.4 0.1 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF5095 PF17016.5 CCF40960.1 - 0.16 11.6 0.2 0.17 11.6 0.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF5095) Abhydrolase_1 PF00561.20 CCF40961.1 - 2.3e-27 96.2 0.0 3.5e-27 95.7 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCF40961.1 - 1.3e-15 58.7 2.2 2e-15 58.0 2.2 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCF40961.1 - 4.1e-11 42.6 0.1 7e-08 32.0 0.1 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Ndr PF03096.14 CCF40961.1 - 0.003 16.3 0.0 0.0044 15.8 0.0 1.2 1 0 0 1 1 1 1 Ndr family Peptidase_M16_C PF05193.21 CCF40963.1 - 3.3e-24 85.9 0.0 1.5e-23 83.8 0.0 1.9 2 0 0 2 2 2 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 CCF40963.1 - 1.1e-07 32.0 0.0 2.4e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) UvrA_inter PF17760.1 CCF40963.1 - 0.015 15.4 0.0 0.032 14.3 0.0 1.5 1 0 0 1 1 1 0 UvrA interaction domain Glyco_hydro_61 PF03443.14 CCF40964.1 - 7.4e-65 218.7 0.1 1.1e-64 218.1 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 PRCC PF10253.9 CCF40964.1 - 2.6 8.8 11.7 4.9 7.9 11.7 1.5 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting AIP3 PF03915.13 CCF40966.1 - 1.6e-159 531.4 9.1 2.4e-159 530.8 9.1 1.3 1 0 0 1 1 1 1 Actin interacting protein 3 RasGAP_C PF03836.15 CCF40966.1 - 0.0033 17.6 2.4 0.12 12.6 0.3 3.8 4 0 0 4 4 4 1 RasGAP C-terminus Lectin_N PF03954.14 CCF40966.1 - 0.0041 16.9 1.1 0.031 14.0 0.1 2.9 2 0 0 2 2 2 1 Hepatic lectin, N-terminal domain DivIC PF04977.15 CCF40966.1 - 0.13 12.1 4.8 8.5 6.2 0.1 3.6 3 0 0 3 3 3 0 Septum formation initiator Med11 PF10280.9 CCF40966.1 - 0.3 11.6 7.1 2.1 8.8 0.1 3.7 2 2 0 2 2 2 0 Mediator complex protein DUF1664 PF07889.12 CCF40966.1 - 0.68 10.0 6.6 7.9 6.5 0.3 3.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) NPV_P10 PF05531.12 CCF40966.1 - 0.75 10.3 7.3 1.8 9.1 0.3 3.8 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein Baculo_PEP_C PF04513.12 CCF40966.1 - 1.1 9.3 0.0 1.1 9.3 0.0 3.8 5 0 0 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus FliL PF03748.14 CCF40966.1 - 5.3 7.7 5.6 1.6 9.4 0.1 3.1 4 1 1 5 5 5 0 Flagellar basal body-associated protein FliL ATP-synt_Eps PF04627.13 CCF40967.1 - 1.7e-23 82.4 1.3 2e-23 82.1 1.3 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase epsilon chain Mak10 PF04112.13 CCF40968.1 - 9.4e-56 187.9 0.0 1.2e-55 187.6 0.0 1.1 1 0 0 1 1 1 1 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase Rubella_E2 PF05749.11 CCF40968.1 - 0.091 12.2 0.2 0.16 11.4 0.0 1.5 2 0 0 2 2 2 0 Rubella membrane glycoprotein E2 AA_permease PF00324.21 CCF40971.1 - 1.6e-130 435.9 46.0 2e-130 435.6 46.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CCF40971.1 - 3e-30 105.4 52.1 3.7e-30 105.1 52.1 1.0 1 0 0 1 1 1 1 Amino acid permease DUF4579 PF15158.6 CCF40971.1 - 8.8 6.0 7.1 21 4.8 1.9 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4579) DUF1772 PF08592.11 CCF40972.1 - 4.7e-16 59.4 0.1 5.3e-16 59.2 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1772) Zn_clus PF00172.18 CCF40973.1 - 1.5e-06 28.2 7.6 2.8e-06 27.4 7.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 CCF40973.1 - 8.5e-05 21.5 0.0 0.00014 20.8 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Mac PF12464.8 CCF40973.1 - 0.12 12.7 0.2 0.25 11.6 0.2 1.6 1 0 0 1 1 1 0 Maltose acetyltransferase Sugar_tr PF00083.24 CCF40974.1 - 1.8e-65 221.6 2.5 2.1e-65 221.4 2.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF40974.1 - 1.2e-08 34.3 5.5 1.5e-08 34.0 5.5 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Glyco_hydro_17 PF00332.18 CCF40975.1 - 0.00034 20.3 0.2 0.00045 19.9 0.2 1.5 1 1 0 1 1 1 1 Glycosyl hydrolases family 17 DUF4126 PF13548.6 CCF40976.1 - 0.0085 15.8 0.6 0.0086 15.8 0.6 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4126) MIP PF00230.20 CCF40978.1 - 3.2e-12 46.6 3.5 3.6e-12 46.5 3.5 1.0 1 0 0 1 1 1 1 Major intrinsic protein DUF3477 PF11963.8 CCF40979.1 - 0.14 11.4 0.1 0.18 11.0 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3477) Cyclase PF04199.13 CCF40980.1 - 1.2e-07 32.1 0.0 2e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 Putative cyclase Peptidase_M28 PF04389.17 CCF40981.1 - 4.3e-30 104.9 0.2 1.2e-29 103.5 0.0 1.6 2 0 0 2 2 2 1 Peptidase family M28 Peptidase_M20 PF01546.28 CCF40981.1 - 0.00028 20.7 0.0 0.00042 20.1 0.0 1.4 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 RXT2_N PF08595.11 CCF40982.1 - 1.2 9.2 9.7 7 6.7 3.8 2.5 2 0 0 2 2 2 0 RXT2-like, N-terminal FAM176 PF14851.6 CCF40982.1 - 5.1 6.7 9.2 3.2 7.4 0.9 3.0 3 0 0 3 3 3 0 FAM176 family HGTP_anticodon2 PF12745.7 CCF40984.1 - 8.7e-85 284.4 5.4 1.2e-84 284.0 5.4 1.1 1 0 0 1 1 1 1 Anticodon binding domain of tRNAs tRNA-synt_His PF13393.6 CCF40984.1 - 3.4e-07 29.8 0.1 8.8e-07 28.5 0.0 1.7 2 0 0 2 2 2 1 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 CCF40984.1 - 9.4e-05 22.5 0.0 0.00042 20.4 0.0 2.1 2 0 0 2 2 2 1 Anticodon binding domain LAGLIDADG_3 PF14528.6 CCF40984.1 - 0.044 14.1 0.0 1.6 9.1 0.0 2.5 2 0 0 2 2 2 0 LAGLIDADG-like domain Pkinase PF00069.25 CCF40987.1 - 9.3e-55 185.8 0.0 1.2e-54 185.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF40987.1 - 3e-25 89.0 0.0 4.6e-25 88.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF40987.1 - 1.5e-07 31.1 0.0 2.8e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 CCF40987.1 - 0.071 13.0 0.0 2.9 7.7 0.0 2.4 2 0 0 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 CCF40987.1 - 0.077 12.3 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Cas6 PF09559.10 CCF40988.1 - 0.0078 16.2 0.0 0.0086 16.1 0.0 1.2 1 0 0 1 1 1 1 Cas6 Crispr UQ_con PF00179.26 CCF40989.1 - 9.7e-48 161.4 0.0 1.2e-47 161.1 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 CCF40989.1 - 5.9e-06 26.0 0.0 7.8e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 CCF40989.1 - 0.022 15.1 0.0 0.025 14.9 0.0 1.3 1 0 0 1 1 1 0 RWD domain UEV PF05743.13 CCF40989.1 - 0.028 14.3 0.1 0.044 13.7 0.1 1.4 1 1 0 1 1 1 0 UEV domain Ribosomal_L31e PF01198.19 CCF40990.1 - 6.2e-39 132.1 0.4 8.5e-39 131.7 0.4 1.2 1 0 0 1 1 1 1 Ribosomal protein L31e RGS PF00615.19 CCF40991.1 - 2.3e-12 47.2 0.0 1.2e-10 41.7 0.0 2.2 1 1 0 1 1 1 1 Regulator of G protein signaling domain SNF2_N PF00176.23 CCF40992.1 - 2.1e-66 224.0 0.0 2.7e-66 223.7 0.0 1.1 1 0 0 1 1 1 1 SNF2 family N-terminal domain HIRAN PF08797.11 CCF40992.1 - 2.3e-18 65.9 0.0 4.7e-18 64.9 0.0 1.5 1 0 0 1 1 1 1 HIRAN domain CDO_I PF05995.12 CCF40993.1 - 1.7e-39 134.8 0.0 1.9e-39 134.7 0.0 1.0 1 0 0 1 1 1 1 Cysteine dioxygenase type I DEC1 PF15859.5 CCF40993.1 - 0.056 13.5 0.0 0.092 12.8 0.0 1.3 1 0 0 1 1 1 0 Deleted in esophageal cancer 1 family PCO_ADO PF07847.12 CCF40993.1 - 0.091 12.2 0.1 0.091 12.2 0.1 1.7 2 1 0 2 2 2 0 PCO_ADO GFA PF04828.14 CCF40995.1 - 4.2e-13 49.5 0.2 6.5e-05 23.2 0.0 3.4 2 1 1 3 3 3 3 Glutathione-dependent formaldehyde-activating enzyme SET PF00856.28 CCF40997.1 - 8.4e-06 26.3 0.0 1.4e-05 25.6 0.0 1.3 1 0 0 1 1 1 1 SET domain PYRIN PF02758.16 CCF40997.1 - 0.051 13.7 0.1 0.096 12.8 0.1 1.5 1 0 0 1 1 1 0 PAAD/DAPIN/Pyrin domain Zn_clus PF00172.18 CCF40998.1 - 9.2e-08 32.1 9.0 2.2e-07 30.9 9.0 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CCF40998.1 - 0.00061 18.9 0.4 0.0065 15.5 0.0 2.4 2 1 0 2 2 2 1 Fungal specific transcription factor domain FMO-like PF00743.19 CCF40999.1 - 3.8e-12 45.4 0.0 2.5e-09 36.1 0.0 2.0 2 0 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 CCF40999.1 - 7.3e-12 45.1 0.0 1.5e-09 37.6 0.0 2.3 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CCF40999.1 - 1.8e-09 37.2 0.0 1.2e-06 28.0 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CCF40999.1 - 2.9e-08 33.2 0.0 1.6e-06 27.5 0.0 2.1 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) IlvN PF07991.12 CCF40999.1 - 0.079 12.5 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain Pyr_redox PF00070.27 CCF40999.1 - 0.17 12.4 0.0 0.36 11.4 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_4 PF01565.23 CCF41000.1 - 4.6e-22 78.3 0.6 7.6e-22 77.6 0.6 1.4 1 0 0 1 1 1 1 FAD binding domain Mito_carr PF00153.27 CCF41001.1 - 2e-10 40.5 0.0 3.6e-10 39.6 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial carrier protein GTP_EFTU PF00009.27 CCF41002.1 - 0.14 11.7 0.3 0.18 11.3 0.3 1.1 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain NAD_binding_6 PF08030.12 CCF41003.1 - 4.8e-24 85.3 0.0 7.3e-24 84.7 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 CCF41003.1 - 1.1e-22 80.2 0.0 2.4e-22 79.1 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.19 CCF41003.1 - 3.3e-18 66.0 10.3 3.3e-18 66.0 10.3 2.4 1 1 1 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_1 PF00175.21 CCF41003.1 - 0.18 12.5 0.0 2.7 8.7 0.0 2.2 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain Arginase PF00491.21 CCF41005.1 - 4e-81 272.6 0.1 4.9e-81 272.3 0.1 1.0 1 0 0 1 1 1 1 Arginase family Nse4_C PF08743.10 CCF41006.1 - 4.1e-34 116.7 0.1 7.7e-34 115.8 0.1 1.5 1 0 0 1 1 1 1 Nse4 C-terminal Nse4-Nse3_bdg PF15412.6 CCF41006.1 - 8e-17 61.1 2.5 1.8e-16 60.0 0.0 2.7 3 0 0 3 3 3 1 Binding domain of Nse4/EID3 to Nse3-MAGE Dehydrin PF00257.19 CCF41006.1 - 0.041 14.4 2.0 0.098 13.2 2.0 1.7 1 0 0 1 1 1 0 Dehydrin CholecysA-Rec_N PF09193.10 CCF41009.1 - 0.027 14.5 0.0 0.051 13.6 0.0 1.4 1 0 0 1 1 1 0 Cholecystokinin A receptor, N-terminal ketoacyl-synt PF00109.26 CCF41010.1 - 8.1e-51 173.0 0.0 9.1e-51 172.9 0.0 1.0 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Thiolase_N PF00108.23 CCF41010.1 - 0.00024 20.6 0.0 0.00034 20.1 0.0 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain ACP_syn_III PF08545.10 CCF41010.1 - 0.18 11.7 0.1 0.41 10.5 0.1 1.7 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III SAT PF16073.5 CCF41011.1 - 1.6e-33 116.5 0.0 1.9e-33 116.2 0.0 1.1 1 0 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis tRNA-synt_1g PF09334.11 CCF41013.1 - 8.4e-96 321.1 0.1 5.8e-95 318.3 0.1 1.9 1 1 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 CCF41013.1 - 4.3e-21 74.8 4.6 9.3e-09 34.1 0.1 3.9 1 1 1 3 3 3 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 CCF41013.1 - 1.2e-08 34.7 0.0 0.0048 16.3 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain Anticodon_1 PF08264.13 CCF41013.1 - 0.027 14.4 0.0 0.11 12.5 0.0 1.9 2 0 0 2 2 2 0 Anticodon-binding domain of tRNA NTF2 PF02136.20 CCF41014.1 - 0.01 16.4 0.1 0.047 14.3 0.1 1.9 1 1 0 1 1 1 0 Nuclear transport factor 2 (NTF2) domain FAD_binding_3 PF01494.19 CCF41015.1 - 5.9e-21 75.1 0.0 4.5e-20 72.2 0.0 2.0 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CCF41015.1 - 0.0019 17.5 0.2 0.036 13.3 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCF41015.1 - 0.0032 18.0 1.4 0.011 16.3 0.0 2.6 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 CCF41015.1 - 0.0046 16.3 0.1 0.2 10.9 0.0 2.2 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase Lycopene_cycl PF05834.12 CCF41015.1 - 0.0072 15.4 1.1 0.32 10.0 0.0 2.6 3 0 0 3 3 3 1 Lycopene cyclase protein DAO PF01266.24 CCF41015.1 - 0.018 14.6 0.0 0.076 12.6 0.0 2.1 1 1 1 2 2 2 0 FAD dependent oxidoreductase Trp_halogenase PF04820.14 CCF41015.1 - 0.029 13.2 0.0 3 6.6 0.0 2.5 2 1 1 3 3 3 0 Tryptophan halogenase NAD_binding_8 PF13450.6 CCF41015.1 - 0.055 13.7 0.0 0.23 11.7 0.0 2.1 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 CCF41015.1 - 0.17 11.1 0.1 9 5.4 0.1 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Vps8 PF12816.7 CCF41016.1 - 4.1e-26 91.7 1.6 4.8e-26 91.5 1.6 1.0 1 0 0 1 1 1 1 Golgi CORVET complex core vacuolar protein 8 PTH2 PF01981.16 CCF41018.1 - 5.7e-45 152.4 0.3 7.5e-45 152.0 0.3 1.2 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 CPT PF07931.12 CCF41019.1 - 4.9e-05 23.2 0.0 8.4e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein AAA_18 PF13238.6 CCF41019.1 - 0.00031 21.3 0.0 0.00088 19.8 0.0 1.8 1 1 0 1 1 1 1 AAA domain DUF826 PF05696.11 CCF41019.1 - 0.0051 16.9 0.1 0.011 15.7 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF826) PRK PF00485.18 CCF41019.1 - 0.0077 16.0 0.0 0.017 14.8 0.0 1.8 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_28 PF13521.6 CCF41019.1 - 0.028 14.6 0.0 0.046 14.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain CoaE PF01121.20 CCF41019.1 - 0.095 12.4 0.0 0.21 11.2 0.0 1.6 1 0 0 1 1 1 0 Dephospho-CoA kinase AAA_16 PF13191.6 CCF41019.1 - 0.17 12.2 0.0 0.33 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain Glyco_hydro_15 PF00723.21 CCF41020.1 - 1.6e-101 340.3 0.0 1.9e-101 340.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 CBM_20 PF00686.19 CCF41020.1 - 3.8e-34 116.5 0.5 7.9e-34 115.4 0.5 1.6 1 0 0 1 1 1 1 Starch binding domain SART-1 PF03343.13 CCF41021.1 - 6.2e-187 623.0 66.4 7.1e-187 622.8 66.4 1.0 1 0 0 1 1 1 1 SART-1 family PRIMA1 PF16101.5 CCF41022.1 - 0.36 10.9 3.7 0.65 10.0 3.7 1.4 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 VHS PF00790.19 CCF41023.1 - 2.1e-41 141.1 0.1 2.1e-41 141.1 0.1 2.2 2 0 0 2 2 2 1 VHS domain FYVE PF01363.21 CCF41023.1 - 4.4e-14 52.4 7.6 7.3e-14 51.7 7.6 1.3 1 0 0 1 1 1 1 FYVE zinc finger UIM PF02809.20 CCF41023.1 - 5.6e-06 25.9 16.9 0.0016 18.2 1.5 3.3 3 0 0 3 3 3 2 Ubiquitin interaction motif GAT PF03127.14 CCF41023.1 - 3e-05 24.3 0.1 0.00016 21.9 0.0 2.3 2 0 0 2 2 2 1 GAT domain FYVE_2 PF02318.16 CCF41023.1 - 0.12 12.5 3.0 0.33 11.2 3.0 1.7 1 0 0 1 1 1 0 FYVE-type zinc finger Fer4_2 PF12797.7 CCF41023.1 - 1.8 8.9 10.5 1.5 9.0 0.2 2.6 2 0 0 2 2 2 0 4Fe-4S binding domain HAD_2 PF13419.6 CCF41024.1 - 1.4e-20 74.1 0.0 1.9e-20 73.7 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CCF41024.1 - 3.6e-09 37.2 0.0 0.00015 22.2 0.0 2.2 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 CCF41024.1 - 1.1e-05 25.9 0.0 1.5e-05 25.5 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CCF41024.1 - 0.00019 21.5 0.0 0.00031 20.8 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like GHL6 PF14871.6 CCF41024.1 - 0.0084 16.3 0.0 0.034 14.3 0.0 2.0 2 0 0 2 2 2 1 Hypothetical glycosyl hydrolase 6 Hydrolase_6 PF13344.6 CCF41024.1 - 0.015 15.3 0.0 0.51 10.5 0.1 2.8 2 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase TIP41 PF04176.13 CCF41025.1 - 1.2e-68 230.0 0.5 1.5e-68 229.6 0.5 1.1 1 0 0 1 1 1 1 TIP41-like family ABC1 PF03109.16 CCF41028.1 - 4.8e-22 78.4 0.0 1.3e-21 76.9 0.0 1.7 1 0 0 1 1 1 1 ABC1 family APH PF01636.23 CCF41028.1 - 7.1e-05 22.8 0.0 0.00017 21.6 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase PF00069.25 CCF41029.1 - 4.4e-37 127.9 0.0 4.8e-37 127.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF41029.1 - 1e-26 93.8 0.0 1.3e-26 93.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CCF41029.1 - 0.00037 19.9 0.0 0.00053 19.4 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CCF41029.1 - 0.00079 19.4 0.0 0.13 12.2 0.0 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family WD40 PF00400.32 CCF41030.1 - 1.9e-12 47.5 0.3 0.49 11.4 0.0 6.7 7 0 0 7 7 7 4 WD domain, G-beta repeat UDPGT PF00201.18 CCF41031.1 - 0.004 16.0 0.0 0.006 15.4 0.0 1.2 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase ATG_C PF09333.11 CCF41031.1 - 0.0064 16.8 0.0 0.82 10.0 0.0 2.7 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain Glyco_tran_28_C PF04101.16 CCF41031.1 - 0.02 14.8 0.0 0.035 14.1 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase family 28 C-terminal domain ArgJ PF01960.18 CCF41031.1 - 0.14 10.8 0.0 0.2 10.4 0.0 1.1 1 0 0 1 1 1 0 ArgJ family NMT1 PF09084.11 CCF41032.1 - 1.6e-78 263.6 0.0 1.9e-78 263.3 0.0 1.1 1 0 0 1 1 1 1 NMT1/THI5 like NMT1_2 PF13379.6 CCF41032.1 - 7.3e-06 25.9 0.0 0.34 10.6 0.0 3.6 3 1 1 4 4 4 2 NMT1-like family GDPD PF03009.17 CCF41036.1 - 2e-21 76.9 0.0 2.1e-21 76.8 0.0 1.0 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Plus-3 PF03126.18 CCF41037.1 - 6.3e-30 103.9 0.0 2.2e-29 102.2 0.0 2.0 2 0 0 2 2 2 1 Plus-3 domain Glucan_synthase PF02364.15 CCF41039.1 - 0 1375.8 0.0 0 1374.7 0.0 1.5 1 0 0 1 1 1 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.6 CCF41039.1 - 1.1e-43 148.6 0.2 4.1e-43 146.8 0.2 2.0 1 0 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 DUF4083 PF13314.6 CCF41040.1 - 0.064 13.2 0.1 0.17 11.8 0.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4083) DUF5102 PF17104.5 CCF41042.1 - 2.3e-98 329.8 0.9 2.6e-98 329.7 0.9 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF5102) DUF2452 PF10504.9 CCF41042.1 - 0.14 11.6 0.0 0.22 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2452) eIF2_C PF09173.11 CCF41043.1 - 2.7e-34 117.3 0.5 6.2e-34 116.1 0.5 1.7 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU PF00009.27 CCF41043.1 - 1.5e-22 80.1 1.3 1e-21 77.4 1.3 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 CCF41043.1 - 7.9e-11 42.2 0.1 1.7e-10 41.2 0.1 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CCF41043.1 - 0.0037 17.3 0.0 0.0086 16.2 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase MMR_HSR1_Xtn PF16897.5 CCF41043.1 - 0.0052 16.8 0.9 0.018 15.0 0.1 2.1 2 0 0 2 2 2 1 C-terminal region of MMR_HSR1 domain RsgA_GTPase PF03193.16 CCF41043.1 - 0.023 14.6 0.3 0.23 11.4 0.1 2.2 2 0 0 2 2 2 0 RsgA GTPase MARVEL PF01284.23 CCF41045.1 - 0.0096 16.0 8.4 0.081 13.0 6.0 2.4 2 1 0 2 2 2 1 Membrane-associating domain Cation_efflux PF01545.21 CCF41045.1 - 1.1 8.9 4.9 3.4 7.4 4.9 1.7 1 1 1 2 2 2 0 Cation efflux family Cpn60_TCP1 PF00118.24 CCF41046.1 - 3.3e-146 487.8 16.3 3.7e-146 487.6 16.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family HECT PF00632.25 CCF41046.1 - 0.18 11.3 0.0 0.28 10.6 0.0 1.2 1 0 0 1 1 1 0 HECT-domain (ubiquitin-transferase) AAA PF00004.29 CCF41047.1 - 1.2e-40 138.9 0.0 2.2e-40 138.2 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CCF41047.1 - 2.1e-07 30.6 0.0 5.3e-07 29.3 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 CCF41047.1 - 6.3e-05 23.0 0.1 0.00043 20.3 0.0 2.5 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 CCF41047.1 - 0.00011 22.4 0.0 0.0069 16.7 0.0 2.5 1 1 1 2 2 2 1 AAA domain AAA_2 PF07724.14 CCF41047.1 - 0.0003 20.9 0.0 0.00083 19.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 CCF41047.1 - 0.00051 20.5 0.1 0.01 16.2 0.0 2.3 1 1 0 2 2 2 1 AAA ATPase domain DUF815 PF05673.13 CCF41047.1 - 0.0018 17.5 0.0 0.0033 16.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 CCF41047.1 - 0.008 15.9 0.0 0.016 15.0 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 CCF41047.1 - 0.025 14.8 0.1 0.063 13.5 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 CCF41047.1 - 0.031 13.8 0.0 0.097 12.2 0.0 1.8 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_33 PF13671.6 CCF41047.1 - 0.051 13.7 0.0 0.094 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 CCF41047.1 - 0.056 13.8 0.0 0.16 12.4 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_30 PF13604.6 CCF41047.1 - 0.069 12.9 0.1 0.59 9.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_3 PF07726.11 CCF41047.1 - 0.08 12.8 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 CCF41047.1 - 0.093 12.4 0.1 0.28 10.9 0.0 1.9 2 1 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 CCF41047.1 - 0.1 12.5 0.6 11 5.9 0.0 2.9 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea Mg_chelatase PF01078.21 CCF41047.1 - 0.16 11.3 0.0 0.36 10.2 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Cytochrom_C1 PF02167.15 CCF41049.1 - 1.8e-91 305.7 0.0 2.2e-91 305.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome C1 family Cytochrome_CBB3 PF13442.6 CCF41049.1 - 0.006 16.9 0.0 0.014 15.7 0.0 1.7 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III DAHP_synth_1 PF00793.20 CCF41050.1 - 2e-81 272.9 0.0 2.3e-81 272.7 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family Sugar_tr PF00083.24 CCF41051.1 - 1.5e-70 238.3 17.6 1.7e-70 238.1 17.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF41051.1 - 8e-21 74.3 50.9 1.1e-12 47.5 21.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily ABC2_membrane_2 PF12679.7 CCF41051.1 - 0.44 9.8 10.0 0.9 8.8 10.0 1.6 1 0 0 1 1 1 0 ABC-2 family transporter protein Fungal_trans PF04082.18 CCF41052.1 - 2e-22 79.5 0.0 3.3e-22 78.8 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF41052.1 - 8.5e-06 25.8 15.8 1.5e-05 25.0 15.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain 14-3-3 PF00244.20 CCF41053.1 - 1.6e-107 358.1 0.3 2e-107 357.8 0.3 1.1 1 0 0 1 1 1 1 14-3-3 protein Ribosomal_60s PF00428.19 CCF41053.1 - 0.015 15.9 7.6 0.071 13.7 3.9 2.5 2 0 0 2 2 2 0 60s Acidic ribosomal protein CorA PF01544.18 CCF41055.1 - 0.00048 19.5 1.0 0.00079 18.8 0.1 1.7 2 0 0 2 2 2 1 CorA-like Mg2+ transporter protein ICE2 PF08426.10 CCF41057.1 - 7.1e-09 35.3 0.0 8e-09 35.1 0.0 1.0 1 0 0 1 1 1 1 ICE2 Hydrolase_4 PF12146.8 CCF41058.1 - 0.11 11.7 0.0 5.8 6.1 0.0 2.4 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Fungal_trans PF04082.18 CCF41060.1 - 1.1e-23 83.6 0.2 1.8e-23 82.9 0.2 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF41061.1 - 2.8e-08 33.8 9.8 4.5e-08 33.1 9.8 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SUIM_assoc PF16619.5 CCF41061.1 - 0.0068 16.5 9.0 0.014 15.5 0.5 2.7 1 1 1 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 TFIIE-A_C PF11521.8 CCF41061.1 - 0.011 16.0 4.4 0.033 14.5 4.4 1.8 1 0 0 1 1 1 0 C-terminal general transcription factor TFIIE alpha Cwf_Cwc_15 PF04889.12 CCF41061.1 - 0.21 11.3 11.3 0.071 12.8 7.5 1.9 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Myc_N PF01056.18 CCF41061.1 - 0.85 9.5 11.6 0.027 14.4 2.4 2.2 2 0 0 2 2 2 0 Myc amino-terminal region DUF3245 PF11595.8 CCF41061.1 - 1.4 9.4 6.1 5.4 7.5 6.1 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3245) FAM176 PF14851.6 CCF41061.1 - 1.6 8.4 6.3 0.55 9.9 2.1 2.2 2 0 0 2 2 2 0 FAM176 family PBP1_TM PF14812.6 CCF41061.1 - 3.1 8.2 12.9 0.15 12.4 6.1 2.1 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal COG6 PF06419.11 CCF41062.1 - 5.5e-218 725.2 4.3 6.3e-218 725.0 4.3 1.0 1 0 0 1 1 1 1 Conserved oligomeric complex COG6 Sec34 PF04136.15 CCF41062.1 - 0.043 13.7 3.6 0.096 12.6 0.1 3.2 4 0 0 4 4 4 0 Sec34-like family RmuC PF02646.16 CCF41062.1 - 0.18 10.9 2.5 0.3 10.2 0.3 2.4 2 0 0 2 2 2 0 RmuC family COG2 PF06148.11 CCF41062.1 - 0.19 11.8 4.4 0.094 12.8 0.3 2.5 3 0 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Muted PF14942.6 CCF41062.1 - 8.8 6.7 7.1 2.1 8.7 0.8 2.9 3 0 0 3 3 3 0 Organelle biogenesis, Muted-like protein Ribosomal_L1 PF00687.21 CCF41063.1 - 1.5e-22 80.3 0.1 2e-22 79.9 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family tRNA-synt_1c PF00749.21 CCF41064.1 - 6.3e-105 350.5 0.1 9e-105 350.0 0.1 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 CCF41064.1 - 5.2e-39 133.9 0.0 1.1e-38 132.9 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain tRNA-synt_1e PF01406.19 CCF41064.1 - 0.0063 15.9 0.2 0.014 14.8 0.2 1.5 1 1 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain 2-Hacid_dh_C PF02826.19 CCF41065.1 - 3.3e-36 124.3 0.0 4.6e-36 123.8 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CCF41065.1 - 7.4e-09 35.4 0.0 1e-08 34.9 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 CCF41065.1 - 3.7e-06 27.2 0.0 5.9e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase ADH_zinc_N PF00107.26 CCF41068.1 - 0.0016 18.4 0.3 0.0034 17.4 0.3 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCF41068.1 - 0.0076 16.1 0.0 0.015 15.2 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Glyco_hydro_79C PF16862.5 CCF41069.1 - 9e-19 68.3 1.1 2.2e-18 67.0 1.1 1.7 1 0 0 1 1 1 1 Glycosyl hydrolase family 79 C-terminal beta domain HTH_51 PF18558.1 CCF41071.1 - 1.2e-30 105.2 0.1 3.2e-30 103.8 0.1 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain Methyltransf_12 PF08242.12 CCF41071.1 - 3e-17 63.2 0.0 1.1e-16 61.3 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF41071.1 - 2.3e-12 47.4 0.0 4.6e-12 46.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF41071.1 - 1.7e-11 44.6 0.0 3.4e-11 43.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF41071.1 - 3.5e-11 43.2 0.0 6.5e-11 42.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF41071.1 - 1.4e-07 31.4 0.0 2.5e-07 30.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCF41071.1 - 7.4e-06 25.5 0.0 0.00016 21.1 0.0 2.7 3 0 0 3 3 3 1 ubiE/COQ5 methyltransferase family Methyltransf_24 PF13578.6 CCF41071.1 - 0.0014 19.6 0.0 0.0067 17.4 0.0 2.1 3 0 0 3 3 3 1 Methyltransferase domain NodS PF05401.11 CCF41071.1 - 0.028 14.0 0.0 0.049 13.2 0.0 1.3 1 0 0 1 1 1 0 Nodulation protein S (NodS) Methyltransf_33 PF10017.9 CCF41071.1 - 0.061 12.5 0.0 0.094 11.9 0.0 1.2 1 0 0 1 1 1 0 Histidine-specific methyltransferase, SAM-dependent PNGaseA PF12222.8 CCF41072.1 - 2.3e-161 537.5 0.0 3.1e-161 537.1 0.0 1.1 1 0 0 1 1 1 1 Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A Pkinase PF00069.25 CCF41073.1 - 3.9e-27 95.3 0.0 2.1e-26 92.9 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF41073.1 - 5e-07 29.3 0.0 0.0007 19.0 0.0 2.6 3 0 0 3 3 3 2 Protein tyrosine kinase Glyco_hydro_10 PF00331.20 CCF41074.1 - 1e-100 337.0 0.2 1.2e-100 336.7 0.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 Glyco_hydro_42 PF02449.15 CCF41074.1 - 0.085 12.2 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 Beta-galactosidase HTH_42 PF06224.12 CCF41074.1 - 0.11 12.1 0.1 0.17 11.4 0.1 1.2 1 0 0 1 1 1 0 Winged helix DNA-binding domain PhyH PF05721.13 CCF41076.1 - 2.2e-11 44.4 0.1 4.7e-11 43.3 0.1 1.5 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DUF1479 PF07350.12 CCF41076.1 - 1.4e-07 30.6 0.1 4.4e-05 22.4 0.1 2.8 2 1 0 2 2 2 2 Protein of unknown function (DUF1479) 2OG-FeII_Oxy_3 PF13640.6 CCF41076.1 - 0.038 14.9 0.0 0.07 14.0 0.0 1.5 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Fungal_trans PF04082.18 CCF41077.1 - 6.6e-10 38.5 0.1 2.3e-09 36.7 0.0 1.9 2 0 0 2 2 2 1 Fungal specific transcription factor domain Roughex PF06020.11 CCF41077.1 - 0.27 10.3 6.9 0.44 9.6 6.9 1.2 1 0 0 1 1 1 0 Drosophila roughex protein SUIM_assoc PF16619.5 CCF41077.1 - 3 8.0 14.6 0.082 13.0 3.3 2.6 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 zf-C2H2 PF00096.26 CCF41079.1 - 6.4e-24 83.0 22.9 1.3e-06 28.5 0.7 4.5 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CCF41079.1 - 1.9e-18 66.0 25.9 4.2e-09 36.4 1.0 4.8 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 CCF41079.1 - 2.4e-14 52.8 19.5 0.00023 21.7 0.5 4.6 4 0 0 4 4 4 4 C2H2-type zinc finger zf-met PF12874.7 CCF41079.1 - 0.00042 20.6 12.2 1.4 9.5 0.2 4.9 5 0 0 5 5 5 2 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 CCF41079.1 - 0.00053 19.9 9.6 0.023 14.7 0.7 3.8 3 0 0 3 3 3 1 C2H2-type zinc finger zf-H2C2_5 PF13909.6 CCF41079.1 - 0.0026 17.5 0.2 0.0026 17.5 0.2 3.7 4 0 0 4 4 4 2 C2H2-type zinc-finger domain zf-C2H2_11 PF16622.5 CCF41079.1 - 0.0074 16.0 0.5 2.2 8.1 0.0 2.9 3 0 0 3 3 3 1 zinc-finger C2H2-type zf-C2H2_8 PF15909.5 CCF41079.1 - 0.0098 16.2 5.6 0.066 13.5 3.0 3.0 1 1 2 3 3 3 1 C2H2-type zinc ribbon zf-C2H2_aberr PF17017.5 CCF41079.1 - 0.021 15.0 6.2 2.6 8.2 0.1 3.1 1 1 3 4 4 4 0 Aberrant zinc-finger zf-LYAR PF08790.11 CCF41079.1 - 0.16 11.9 8.8 7.2 6.6 0.2 4.3 4 0 0 4 4 4 0 LYAR-type C2HC zinc finger zf-C2H2_jaz PF12171.8 CCF41079.1 - 0.2 12.0 11.6 0.51 10.7 0.1 4.3 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding FOXP-CC PF16159.5 CCF41079.1 - 0.29 11.8 17.3 0.15 12.7 1.0 3.8 3 1 2 5 5 4 0 FOXP coiled-coil domain zf_UBZ PF18439.1 CCF41079.1 - 0.87 9.2 4.6 5.3 6.7 0.1 3.8 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger zf-C2HE PF16278.5 CCF41079.1 - 1.8 9.1 9.6 0.87 10.1 0.3 3.1 2 1 1 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger DUF1752 PF08550.10 CCF41080.1 - 1.1e-10 41.2 7.3 1.5e-10 40.7 5.8 2.1 2 0 0 2 2 2 1 Fungal protein of unknown function (DUF1752) RRM_1 PF00076.22 CCF41081.1 - 3.2e-16 58.9 0.0 6.1e-13 48.4 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CCF41081.1 - 0.044 13.6 0.0 0.086 12.7 0.0 1.4 1 0 0 1 1 1 0 Occluded RNA-recognition motif RRM_Rrp7 PF17799.1 CCF41081.1 - 0.089 12.6 0.0 0.37 10.6 0.0 1.8 2 0 0 2 2 2 0 Rrp7 RRM-like N-terminal domain Cu-oxidase_3 PF07732.15 CCF41082.1 - 3.5e-36 123.8 1.4 6.8e-36 122.9 0.0 2.2 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 CCF41082.1 - 1.7e-29 102.3 5.9 5.1e-24 84.6 0.3 3.9 3 1 1 4 4 4 2 Multicopper oxidase Cu-oxidase PF00394.22 CCF41082.1 - 2.7e-13 50.3 0.9 1.4e-11 44.8 0.1 2.7 2 1 0 2 2 2 1 Multicopper oxidase RHD_dimer PF16179.5 CCF41082.1 - 0.15 12.1 0.0 13 5.8 0.0 2.3 2 0 0 2 2 2 0 Rel homology dimerisation domain NmrA PF05368.13 CCF41083.1 - 3.2e-13 49.8 0.0 1.1e-12 48.0 0.0 1.7 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CCF41083.1 - 6.5e-12 45.7 0.0 1.1e-11 45.0 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CCF41083.1 - 0.00035 20.1 0.1 0.0018 17.8 0.0 1.9 1 1 1 2 2 2 1 NAD dependent epimerase/dehydratase family NAD_binding_2 PF03446.15 CCF41083.1 - 0.0039 17.4 0.0 0.023 14.9 0.0 2.0 2 1 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_7 PF13241.6 CCF41083.1 - 0.0095 16.4 0.0 0.021 15.3 0.0 1.6 1 0 0 1 1 1 1 Putative NAD(P)-binding F420_oxidored PF03807.17 CCF41083.1 - 0.023 15.3 0.0 0.041 14.5 0.0 1.4 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 CCF41083.1 - 0.051 13.6 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 CCF41083.1 - 0.055 12.8 0.0 0.1 11.9 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FAD_binding_4 PF01565.23 CCF41084.1 - 1e-19 70.7 0.2 1.5e-19 70.1 0.2 1.3 1 0 0 1 1 1 1 FAD binding domain ketoacyl-synt PF00109.26 CCF41085.1 - 5e-68 229.4 0.5 1.2e-67 228.2 0.1 1.9 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 CCF41085.1 - 2.3e-40 139.1 1.6 3.9e-40 138.3 1.6 1.3 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 CCF41085.1 - 8.9e-33 112.8 4.5 1.6e-32 112.0 3.0 2.3 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Thioesterase PF00975.20 CCF41085.1 - 2.8e-25 89.8 0.1 1.4e-24 87.5 0.0 2.3 2 0 0 2 2 2 1 Thioesterase domain PS-DH PF14765.6 CCF41085.1 - 2.9e-13 49.7 0.0 4.8e-13 49.0 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase PP-binding PF00550.25 CCF41085.1 - 2.6e-11 43.7 0.2 6.2e-11 42.5 0.2 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site KAsynt_C_assoc PF16197.5 CCF41085.1 - 2e-06 28.2 0.0 6.1e-06 26.7 0.0 1.9 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Thiolase_N PF00108.23 CCF41085.1 - 3.3e-05 23.4 0.8 0.00016 21.2 0.1 2.4 2 1 0 2 2 2 1 Thiolase, N-terminal domain ACP_syn_III PF08545.10 CCF41085.1 - 0.054 13.4 0.9 0.43 10.5 0.0 2.8 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Abhydrolase_3 PF07859.13 CCF41085.1 - 0.074 12.9 0.0 0.19 11.5 0.0 1.7 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF2974 PF11187.8 CCF41085.1 - 0.15 11.6 0.1 1.3 8.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) DUF1992 PF09350.10 CCF41086.1 - 1.1e-20 73.5 0.3 4.2e-20 71.7 0.3 2.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1992) TRCF PF03461.15 CCF41086.1 - 0.0063 16.9 0.1 0.11 12.9 0.0 2.4 2 0 0 2 2 2 1 TRCF domain adh_short PF00106.25 CCF41087.1 - 4.2e-36 124.2 0.0 5.4e-36 123.9 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF41087.1 - 9e-19 67.9 0.0 1.1e-18 67.7 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF41087.1 - 0.00015 21.8 0.2 0.00029 20.8 0.2 1.4 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF41087.1 - 0.005 16.3 0.2 0.011 15.2 0.2 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CCF41087.1 - 0.014 15.3 0.1 0.02 14.8 0.1 1.3 1 0 0 1 1 1 0 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 CCF41087.1 - 0.031 14.5 0.2 0.052 13.8 0.2 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 CCF41087.1 - 0.11 12.6 0.0 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 CCF41087.1 - 0.11 13.1 0.1 0.23 12.1 0.1 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent HHH_5 PF14520.6 CCF41087.1 - 0.14 12.8 0.7 0.79 10.4 0.7 2.1 1 1 0 1 1 1 0 Helix-hairpin-helix domain adh_short_C2 PF13561.6 CCF41088.1 - 1.8e-37 129.1 0.7 2.9e-37 128.5 0.7 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF41088.1 - 2.4e-32 112.0 0.4 3.2e-32 111.6 0.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF41088.1 - 9.6e-09 35.4 1.3 1.6e-07 31.5 1.3 2.0 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 CCF41088.1 - 0.017 14.2 0.0 0.025 13.7 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Epimerase PF01370.21 CCF41088.1 - 0.062 12.8 0.0 0.92 8.9 0.0 2.1 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family ABC_tran PF00005.27 CCF41090.1 - 6.2e-08 33.2 0.0 3.2e-07 31.0 0.0 1.9 2 0 0 2 2 2 1 ABC transporter ALIX_LYPXL_bnd PF13949.6 CCF41090.1 - 0.0077 15.6 0.1 0.011 15.1 0.1 1.3 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV End3 PF12761.7 CCF41090.1 - 0.013 15.6 0.8 0.027 14.6 0.8 1.5 1 0 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 THOC7 PF05615.13 CCF41090.1 - 0.016 15.5 1.6 0.016 15.5 1.6 1.6 2 0 0 2 2 2 0 Tho complex subunit 7 GPS2_interact PF15784.5 CCF41090.1 - 0.11 13.0 2.9 0.22 12.0 2.9 1.5 1 0 0 1 1 1 0 G-protein pathway suppressor 2-interacting domain DUF3539 PF12058.8 CCF41090.1 - 0.3 11.2 1.1 1.5 9.0 1.1 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF3539) Epiglycanin_C PF14654.6 CCF41091.1 - 0.13 12.4 0.0 0.25 11.4 0.0 1.5 1 0 0 1 1 1 0 Mucin, catalytic, TM and cytoplasmic tail region AAA PF00004.29 CCF41094.1 - 3.4e-17 63.1 0.0 2.8e-08 34.3 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 CCF41094.1 - 0.00092 19.0 0.0 0.0033 17.2 0.0 1.8 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 CCF41094.1 - 0.0011 19.4 1.4 0.0042 17.5 1.4 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.6 CCF41094.1 - 0.0011 18.5 0.5 0.0094 15.5 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 CCF41094.1 - 0.0013 18.6 10.3 1.8 8.3 10.6 2.2 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 CCF41094.1 - 0.0019 18.2 0.1 0.0087 16.1 0.0 2.1 1 1 1 2 2 2 1 AAA domain (dynein-related subfamily) ATPase PF06745.13 CCF41094.1 - 0.015 14.6 0.7 0.045 13.1 0.0 2.2 2 1 1 3 3 3 0 KaiC AAA_18 PF13238.6 CCF41094.1 - 0.052 14.1 0.1 0.052 14.1 0.1 3.3 2 2 0 2 2 1 0 AAA domain AAA_29 PF13555.6 CCF41094.1 - 0.052 13.3 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain IstB_IS21 PF01695.17 CCF41094.1 - 0.059 13.1 0.0 0.13 11.9 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein DUF755 PF05501.11 CCF41094.1 - 0.2 12.0 20.4 0.35 11.1 20.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF755) Borrelia_P83 PF05262.11 CCF41094.1 - 0.21 10.0 21.2 0.29 9.6 21.2 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein RR_TM4-6 PF06459.12 CCF41094.1 - 0.35 10.7 16.6 0.52 10.1 16.6 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Raftlin PF15250.6 CCF41094.1 - 0.4 9.4 8.4 0.54 9.0 8.4 1.1 1 0 0 1 1 1 0 Raftlin DDRGK PF09756.9 CCF41094.1 - 0.74 9.4 37.0 3.3 7.3 0.0 2.5 3 0 0 3 3 2 0 DDRGK domain TFIIF_alpha PF05793.12 CCF41094.1 - 0.86 8.1 29.7 1.2 7.6 29.7 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF3807 PF12720.7 CCF41094.1 - 1.9 8.7 21.9 3.4 7.9 21.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) DDHD PF02862.17 CCF41094.1 - 2.1 8.4 9.8 3.6 7.7 9.8 1.4 1 0 0 1 1 1 0 DDHD domain DUF702 PF05142.12 CCF41094.1 - 2.2 8.8 9.1 4.8 7.6 9.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF702) NARP1 PF12569.8 CCF41094.1 - 2.9 6.7 20.7 4 6.2 20.7 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 BORG_CEP PF14957.6 CCF41094.1 - 3 9.0 9.7 5.9 8.1 9.7 1.5 1 0 0 1 1 1 0 Cdc42 effector DUF913 PF06025.12 CCF41094.1 - 3.6 6.5 9.3 5.5 5.9 9.3 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Vfa1 PF08432.10 CCF41094.1 - 4.1 7.7 22.1 6.9 7.0 22.1 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Neur_chan_memb PF02932.16 CCF41094.1 - 5.2 7.0 9.1 8 6.5 9.1 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region ALMT PF11744.8 CCF41094.1 - 5.8 5.6 11.4 7.4 5.3 11.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter PBP_sp32 PF07222.12 CCF41094.1 - 8.3 5.8 12.7 12 5.2 12.7 1.3 1 0 0 1 1 1 0 Proacrosin binding protein sp32 Glyco_hydro_127 PF07944.12 CCF41095.1 - 5.2e-41 140.7 0.0 2.3e-38 132.0 0.0 2.0 1 1 1 2 2 2 2 Beta-L-arabinofuranosidase, GH127 DUF4986 PF16375.5 CCF41095.1 - 0.014 16.1 0.0 0.023 15.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function Pertactin PF03212.14 CCF41095.1 - 0.033 14.1 0.1 0.11 12.5 0.1 1.8 1 1 0 1 1 1 0 Pertactin Oxidored_FMN PF00724.20 CCF41096.1 - 0.004 16.5 0.0 0.0052 16.1 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Dus PF01207.17 CCF41096.1 - 0.14 11.2 0.0 0.15 11.1 0.0 1.1 1 0 0 1 1 1 0 Dihydrouridine synthase (Dus) Fungal_trans PF04082.18 CCF41098.1 - 4e-18 65.4 0.0 8.7e-18 64.3 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF41098.1 - 4.3e-07 29.9 17.5 7.8e-07 29.1 17.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain WD40 PF00400.32 CCF41099.1 - 5e-24 84.1 0.2 1.4e-07 32.1 0.2 5.8 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF41099.1 - 2e-11 44.0 0.0 0.0095 16.2 0.0 4.7 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 CCF41099.1 - 0.0019 17.8 0.0 0.011 15.3 0.0 2.1 1 1 0 1 1 1 1 PQQ-like domain eIF2A PF08662.11 CCF41099.1 - 0.0024 17.8 0.1 2.6 7.9 0.0 2.8 2 2 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A Coatomer_WDAD PF04053.14 CCF41099.1 - 0.0027 16.8 0.1 0.099 11.7 0.0 2.0 1 1 1 2 2 2 1 Coatomer WD associated region WD40_like PF17005.5 CCF41099.1 - 0.0045 16.4 0.0 0.11 11.8 0.0 2.6 1 1 1 2 2 2 1 WD40-like domain Nup160 PF11715.8 CCF41099.1 - 0.0049 15.6 0.0 0.0067 15.1 0.0 1.2 1 0 0 1 1 1 1 Nucleoporin Nup120/160 adh_short PF00106.25 CCF41100.1 - 2.2e-22 79.5 0.0 8.1e-22 77.6 0.0 1.7 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF41100.1 - 4.4e-19 69.0 0.0 7.6e-19 68.2 0.0 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF41100.1 - 0.00035 20.5 0.0 0.00049 20.0 0.0 1.2 1 0 0 1 1 1 1 KR domain Microtub_bd PF16796.5 CCF41101.1 - 1.3e-56 190.7 0.1 1.9e-56 190.2 0.1 1.2 1 0 0 1 1 1 1 Microtubule binding Kinesin PF00225.23 CCF41101.1 - 6.4e-45 153.5 0.1 6.4e-45 153.5 0.1 1.5 2 0 0 2 2 2 1 Kinesin motor domain AAA_22 PF13401.6 CCF41101.1 - 0.0058 16.9 1.1 0.23 11.7 0.3 2.4 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 CCF41101.1 - 0.026 14.9 0.0 0.041 14.3 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain Bac_DnaA PF00308.18 CCF41101.1 - 0.039 13.8 0.0 0.085 12.7 0.0 1.6 1 0 0 1 1 1 0 Bacterial dnaA protein ATPase_2 PF01637.18 CCF41101.1 - 0.067 13.1 0.2 0.27 11.1 0.0 1.9 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea AAA_24 PF13479.6 CCF41101.1 - 0.14 11.9 0.5 0.52 10.0 0.1 2.2 2 1 0 2 2 2 0 AAA domain DUF1768 PF08719.11 CCF41102.1 - 2e-54 184.2 0.0 2.6e-54 183.8 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) TauD PF02668.16 CCF41102.1 - 0.015 15.1 0.0 0.027 14.3 0.0 1.4 1 1 0 1 1 1 0 Taurine catabolism dioxygenase TauD, TfdA family Use1 PF09753.9 CCF41102.1 - 5.4 6.7 9.3 7.7 6.2 9.3 1.1 1 0 0 1 1 1 0 Membrane fusion protein Use1 Tim44 PF04280.15 CCF41103.1 - 2.7e-38 131.4 0.1 8.6e-38 129.7 0.0 1.9 2 0 0 2 2 2 1 Tim44-like domain PPL5 PF18168.1 CCF41103.1 - 0.21 10.9 8.2 0.38 10.0 8.2 1.3 1 0 0 1 1 1 0 Prim-pol family 5 DehI PF10778.9 CCF41103.1 - 0.42 10.7 2.8 0.37 10.9 0.3 2.2 2 0 0 2 2 2 0 Halocarboxylic acid dehydrogenase DehI DNA_pol_phi PF04931.13 CCF41103.1 - 0.66 8.0 11.8 1 7.4 11.8 1.2 1 0 0 1 1 1 0 DNA polymerase phi DUF3347 PF11827.8 CCF41103.1 - 1.8 8.7 9.1 0.83 9.8 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3347) BNIP3 PF06553.12 CCF41103.1 - 9.3 5.9 12.7 0.37 10.4 6.7 1.7 2 0 0 2 2 2 0 BNIP3 Ribosomal_S11 PF00411.19 CCF41104.1 - 3.4e-09 37.1 0.0 5.5e-09 36.4 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S11 Phage_Mu_Gam PF07352.12 CCF41104.1 - 0.21 11.5 0.0 0.33 10.9 0.0 1.3 1 0 0 1 1 1 0 Bacteriophage Mu Gam like protein Peptidase_C97 PF05903.14 CCF41105.1 - 6.6e-36 123.4 0.0 8.2e-36 123.1 0.0 1.1 1 0 0 1 1 1 1 PPPDE putative peptidase domain LRAT PF04970.13 CCF41105.1 - 0.0025 18.1 0.0 0.004 17.5 0.0 1.2 1 0 0 1 1 1 1 Lecithin retinol acyltransferase DUF778 PF05608.12 CCF41105.1 - 0.18 12.2 0.1 0.36 11.2 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF778) YchF-GTPase_C PF06071.13 CCF41106.1 - 1.7e-35 121.0 0.1 4.9e-35 119.6 0.1 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 CCF41106.1 - 2.3e-16 59.9 0.0 5.9e-16 58.6 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase TGS PF02824.21 CCF41106.1 - 0.00024 21.1 0.0 0.0006 19.8 0.0 1.7 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.18 CCF41106.1 - 0.00045 19.8 0.0 0.00091 18.8 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B BetaGal_dom3 PF13363.6 CCF41106.1 - 0.018 14.6 0.0 0.036 13.6 0.0 1.4 1 0 0 1 1 1 0 Beta-galactosidase, domain 3 AAA_18 PF13238.6 CCF41106.1 - 0.055 14.0 0.0 9.7 6.8 0.0 3.2 3 1 0 3 3 3 0 AAA domain AAA_14 PF13173.6 CCF41106.1 - 0.13 12.3 0.0 0.38 10.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain TPR_19 PF14559.6 CCF41107.1 - 0.0053 17.2 1.8 0.49 10.9 0.1 2.8 1 1 2 3 3 3 2 Tetratricopeptide repeat HemY_N PF07219.13 CCF41107.1 - 0.045 14.0 1.2 0.18 12.0 0.8 2.2 1 1 1 2 2 2 0 HemY protein N-terminus TPR_16 PF13432.6 CCF41107.1 - 0.14 12.9 4.2 0.28 11.9 0.4 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 CCF41107.1 - 0.14 12.8 1.0 6.6 7.6 0.0 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_4 PF07721.14 CCF41107.1 - 0.72 10.7 8.5 0.7 10.7 0.7 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat CLZ PF16526.5 CCF41108.1 - 0.19 12.1 0.6 0.48 10.8 0.6 1.7 1 0 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels PspB PF06667.12 CCF41108.1 - 0.21 11.7 1.3 0.39 10.8 0.6 1.8 2 0 0 2 2 2 0 Phage shock protein B SSXT PF05030.12 CCF41110.1 - 0.011 15.3 0.4 0.35 10.5 0.0 2.5 2 0 0 2 2 2 0 SSXT protein (N-terminal region) DUF5527 PF17665.1 CCF41111.1 - 0.16 11.5 0.1 0.16 11.5 0.1 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5527) FAT PF02259.23 CCF41112.1 - 9.6e-72 242.1 6.2 9.6e-72 242.1 6.2 1.6 2 0 0 2 2 2 1 FAT domain PI3_PI4_kinase PF00454.27 CCF41112.1 - 1.1e-35 123.7 0.1 2.3e-35 122.6 0.1 1.6 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 CCF41112.1 - 1.4e-07 31.2 0.2 2.8e-07 30.2 0.2 1.5 1 0 0 1 1 1 1 FATC domain TPR_8 PF13181.6 CCF41112.1 - 0.013 15.7 0.4 0.055 13.7 0.4 2.2 1 0 0 1 1 1 0 Tetratricopeptide repeat AAA_32 PF13654.6 CCF41112.1 - 0.028 13.2 0.0 0.046 12.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain HET PF06985.11 CCF41113.1 - 1.8e-31 109.4 0.1 3.3e-31 108.6 0.1 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) DUF624 PF04854.14 CCF41114.1 - 2.1 8.5 5.3 0.59 10.3 0.2 2.3 2 1 0 2 2 2 0 Protein of unknown function, DUF624 Fungal_trans PF04082.18 CCF41115.1 - 1.7e-41 142.0 0.0 2.9e-41 141.3 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF41115.1 - 3.4e-08 33.5 6.7 7.2e-08 32.4 6.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Abhydrolase_4 PF08386.10 CCF41116.1 - 2.1e-20 72.7 0.1 8.1e-20 70.9 0.0 2.0 3 0 0 3 3 3 1 TAP-like protein Abhydrolase_1 PF00561.20 CCF41116.1 - 7.2e-18 65.2 0.0 1.8e-16 60.6 0.0 2.0 2 0 0 2 2 2 1 alpha/beta hydrolase fold Fib_alpha PF08702.10 CCF41117.1 - 0.62 10.2 18.6 0.62 10.2 4.6 3.1 2 1 2 4 4 4 0 Fibrinogen alpha/beta chain family DUF4615 PF15393.6 CCF41117.1 - 1.2 9.7 12.2 0.27 11.8 6.6 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4615) FapA PF03961.13 CCF41117.1 - 3 6.3 16.2 0.24 9.9 10.8 1.8 2 0 0 2 2 2 0 Flagellar Assembly Protein A Herpes_UL6 PF01763.16 CCF41117.1 - 3.6 6.0 9.0 0.56 8.7 5.3 1.5 2 0 0 2 2 2 0 Herpesvirus UL6 like DUF3450 PF11932.8 CCF41117.1 - 7.8 5.7 21.3 9.8 5.4 17.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) DotU PF09850.9 CCF41117.1 - 8.4 6.1 8.0 8.2 6.1 2.6 2.4 1 1 1 2 2 2 0 Type VI secretion system protein DotU HTH_39 PF14090.6 CCF41118.1 - 0.017 14.9 0.2 0.044 13.5 0.2 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain F-box-like PF12937.7 CCF41119.1 - 7.3e-09 35.4 0.2 7.3e-09 35.4 0.2 2.7 3 0 0 3 3 3 1 F-box-like F-box PF00646.33 CCF41119.1 - 0.21 11.5 4.6 2.7 8.0 2.2 3.5 3 1 0 3 3 3 0 F-box domain GCR1_C PF12550.8 CCF41120.1 - 4.8e-19 68.5 0.2 1.3e-18 67.0 0.2 1.8 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes FMO-like PF00743.19 CCF41120.1 - 4e-05 22.3 0.0 6.5e-05 21.6 0.0 1.3 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Oxidored_FMN PF00724.20 CCF41120.1 - 0.00018 20.9 0.4 0.4 9.9 0.2 2.3 1 1 1 2 2 2 2 NADH:flavin oxidoreductase / NADH oxidase family Pyr_redox_3 PF13738.6 CCF41120.1 - 0.24 10.6 0.6 1.8 7.7 0.1 2.4 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase SBP_bac_6 PF13343.6 CCF41121.1 - 8.2e-09 35.2 1.3 1.1e-08 34.8 1.3 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_11 PF13531.6 CCF41121.1 - 6.9e-05 22.7 0.1 0.00012 22.0 0.1 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein MFS_1 PF07690.16 CCF41122.1 - 7.4e-18 64.6 57.6 1.4e-10 40.6 43.2 4.1 1 1 2 3 3 3 3 Major Facilitator Superfamily DUF2208 PF09973.9 CCF41122.1 - 1.4 8.5 5.6 3.4 7.2 5.6 1.6 1 0 0 1 1 1 0 Predicted membrane protein (DUF2208) GWT1 PF06423.12 CCF41122.1 - 4.3 7.5 6.5 77 3.4 0.0 3.0 2 1 1 3 3 3 0 GWT1 dCMP_cyt_deam_1 PF00383.23 CCF41123.1 - 6.2e-06 26.0 0.1 8.1e-06 25.7 0.1 1.1 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 CCF41123.1 - 0.031 14.0 0.0 0.068 12.9 0.0 1.6 1 1 0 1 1 1 0 MafB19-like deaminase BTB PF00651.31 CCF41125.1 - 1.6e-06 28.3 0.6 0.00028 21.1 0.0 3.0 2 1 1 3 3 3 2 BTB/POZ domain Tetraspanin PF00335.20 CCF41127.1 - 2.3e-05 24.2 7.0 3.2e-05 23.7 7.0 1.2 1 0 0 1 1 1 1 Tetraspanin family DUF4191 PF13829.6 CCF41127.1 - 1.7 8.0 0.0 1.7 8.0 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4191) GerA PF03323.13 CCF41127.1 - 1.9 6.8 4.3 2.2 6.7 0.9 2.4 3 0 0 3 3 3 0 Bacillus/Clostridium GerA spore germination protein FAD_binding_3 PF01494.19 CCF41128.1 - 2.1e-13 50.2 0.4 4.7e-12 45.8 0.0 2.3 2 1 0 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.6 CCF41128.1 - 0.0018 18.5 0.0 0.0044 17.2 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain SE PF08491.10 CCF41128.1 - 0.0024 17.0 0.0 1.2 8.1 0.0 2.2 2 0 0 2 2 2 2 Squalene epoxidase DAO PF01266.24 CCF41128.1 - 0.0039 16.8 0.0 0.0076 15.9 0.0 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCF41128.1 - 0.0042 16.3 0.1 0.02 14.1 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 CCF41128.1 - 0.032 13.1 0.0 0.69 8.7 0.0 2.2 2 0 0 2 2 2 0 Tryptophan halogenase NAD_binding_9 PF13454.6 CCF41128.1 - 0.05 13.6 0.0 1.9 8.5 0.0 2.8 3 0 0 3 3 3 0 FAD-NAD(P)-binding Opy2 PF09463.10 CCF41129.1 - 6.5e-09 36.0 17.5 1.2e-08 35.1 17.5 1.5 1 0 0 1 1 1 1 Opy2 protein DASH_Dad4 PF08650.10 CCF41130.1 - 1.9e-33 114.2 7.7 2.1e-33 114.1 7.7 1.0 1 0 0 1 1 1 1 DASH complex subunit Dad4 Biotin_carb_C PF02785.19 CCF41130.1 - 0.043 13.9 0.1 0.047 13.8 0.1 1.1 1 0 0 1 1 1 0 Biotin carboxylase C-terminal domain GM_CSF PF01109.17 CCF41130.1 - 0.077 13.2 0.7 0.088 13.0 0.7 1.1 1 0 0 1 1 1 0 Granulocyte-macrophage colony-stimulating factor Actin PF00022.19 CCF41131.1 - 2.7e-57 194.2 0.0 5.5e-33 114.2 0.0 2.2 2 0 0 2 2 2 2 Actin ATG2_CAD PF13329.6 CCF41132.1 - 5.8e-56 188.5 1.9 1.6e-55 187.1 1.5 1.9 2 0 0 2 2 2 1 Autophagy-related protein 2 CAD motif ATG_C PF09333.11 CCF41132.1 - 1.2e-33 115.3 0.1 4.8e-32 110.2 0.1 3.0 3 0 0 3 3 3 1 Autophagy-related protein C terminal domain VPS13_C PF16909.5 CCF41132.1 - 0.076 12.8 0.1 0.29 10.9 0.1 2.0 1 0 0 1 1 1 0 Vacuolar-sorting-associated 13 protein C-terminal DNA_pol_E_B PF04042.16 CCF41133.1 - 1.9e-63 213.6 0.0 2.4e-63 213.3 0.0 1.1 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B TPR_2 PF07719.17 CCF41134.1 - 3.8e-05 23.5 1.2 0.024 14.7 0.0 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 CCF41134.1 - 6.7e-05 22.5 0.3 0.00016 21.2 0.3 1.7 1 0 0 1 1 1 1 TPR repeat TPR_12 PF13424.6 CCF41134.1 - 0.0008 19.6 0.5 0.0018 18.5 0.3 1.7 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 CCF41134.1 - 0.0015 18.3 0.2 0.1 12.5 0.1 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 CCF41134.1 - 0.022 15.6 0.8 0.48 11.4 0.0 2.7 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 CCF41134.1 - 0.025 14.6 2.9 2.6 8.3 0.1 3.1 2 1 1 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 CCF41134.1 - 0.056 13.7 1.7 0.18 12.1 1.7 1.9 1 1 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF3316 PF11777.8 CCF41134.1 - 0.11 12.6 0.1 0.14 12.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3316) HAD_2 PF13419.6 CCF41135.1 - 1.3e-15 57.9 0.0 1.6e-07 31.6 0.0 2.2 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CCF41135.1 - 2.9e-07 31.0 0.0 1.1e-05 25.9 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CCF41135.1 - 0.00092 19.2 0.0 0.0019 18.2 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like SPOC PF07744.13 CCF41136.1 - 1.4e-26 93.2 0.0 2.5e-26 92.4 0.0 1.4 1 0 0 1 1 1 1 SPOC domain TFIIS_M PF07500.14 CCF41136.1 - 3.5e-15 56.4 1.0 7e-15 55.5 1.0 1.5 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain Med7 PF05983.11 CCF41138.1 - 8.6e-58 195.6 0.1 1e-57 195.3 0.1 1.1 1 0 0 1 1 1 1 MED7 protein zf-met PF12874.7 CCF41139.1 - 0.018 15.4 0.4 0.029 14.7 0.4 1.3 1 0 0 1 1 1 0 Zinc-finger of C2H2 type DUF1677 PF07911.13 CCF41139.1 - 0.019 15.3 0.1 0.019 15.3 0.1 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF1677) FAM76 PF16046.5 CCF41139.1 - 0.16 11.3 6.0 0.38 10.1 1.5 2.1 2 0 0 2 2 2 0 FAM76 protein zf-C2H2_jaz PF12171.8 CCF41139.1 - 0.18 12.1 0.4 0.33 11.3 0.4 1.3 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding Cwf_Cwc_15 PF04889.12 CCF41139.1 - 0.98 9.1 21.9 1.3 8.7 11.3 2.4 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein CCDC106 PF15794.5 CCF41139.1 - 6.7 6.4 17.5 0.13 12.0 1.1 2.7 2 1 1 3 3 3 0 Coiled-coil domain-containing protein 106 HAUS6_N PF14661.6 CCF41139.1 - 8.2 5.9 10.4 0.44 10.1 3.4 1.9 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus LAMTOR PF15454.6 CCF41141.1 - 4.6e-11 43.2 0.1 7.8e-11 42.4 0.1 1.4 1 0 0 1 1 1 1 Late endosomal/lysosomal adaptor and MAPK and MTOR activator DUF3854 PF12965.7 CCF41142.1 - 0.091 12.7 0.2 0.12 12.4 0.2 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF3854) MFS_1 PF07690.16 CCF41144.1 - 8.4e-26 90.7 40.4 5.1e-22 78.3 35.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TPR_1 PF00515.28 CCF41145.1 - 3.7e-30 102.5 18.4 2.5e-07 30.2 0.0 12.4 13 0 0 13 13 12 6 Tetratricopeptide repeat TPR_2 PF07719.17 CCF41145.1 - 5.5e-30 101.1 29.7 5.6e-06 26.1 0.0 13.8 14 0 0 14 14 14 7 Tetratricopeptide repeat TPR_16 PF13432.6 CCF41145.1 - 1.7e-26 92.5 29.4 1.7e-06 28.5 0.0 10.3 10 2 1 11 11 9 5 Tetratricopeptide repeat TPR_19 PF14559.6 CCF41145.1 - 8e-25 87.1 14.9 1.1e-06 29.1 0.3 9.2 8 1 1 9 9 9 5 Tetratricopeptide repeat TPR_14 PF13428.6 CCF41145.1 - 8.5e-24 82.2 18.6 0.0013 19.4 0.3 13.0 9 5 5 14 14 13 3 Tetratricopeptide repeat TPR_17 PF13431.6 CCF41145.1 - 9e-23 79.0 5.6 0.11 13.0 0.0 11.9 12 0 0 12 12 12 4 Tetratricopeptide repeat TPR_12 PF13424.6 CCF41145.1 - 2.2e-20 72.7 28.2 1.8e-05 24.9 0.0 10.4 9 3 2 11 11 9 5 Tetratricopeptide repeat TPR_8 PF13181.6 CCF41145.1 - 2.4e-18 64.8 22.4 7.9e-05 22.6 0.0 12.7 15 0 0 15 15 13 3 Tetratricopeptide repeat TPR_11 PF13414.6 CCF41145.1 - 1.5e-16 59.7 12.4 0.031 14.0 0.0 9.7 10 1 1 11 11 10 5 TPR repeat TPR_7 PF13176.6 CCF41145.1 - 2.2e-14 52.3 18.5 0.00014 21.6 0.0 11.3 12 1 1 13 13 11 3 Tetratricopeptide repeat TPR_6 PF13174.6 CCF41145.1 - 5e-11 42.5 22.0 0.026 15.1 0.0 13.2 15 0 0 15 15 13 2 Tetratricopeptide repeat TPR_9 PF13371.6 CCF41145.1 - 6e-10 39.1 8.1 0.027 14.6 0.0 6.3 6 1 0 6 6 5 3 Tetratricopeptide repeat ANAPC3 PF12895.7 CCF41145.1 - 2.9e-08 33.8 12.1 0.089 13.0 0.0 7.5 8 1 0 8 8 8 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_20 PF14561.6 CCF41145.1 - 4.1e-07 30.2 2.9 1.1 9.6 0.0 5.1 4 0 0 4 4 4 2 Tetratricopeptide repeat DUF4192 PF13830.6 CCF41145.1 - 0.0019 18.3 3.8 1.3 9.0 0.1 3.0 3 0 0 3 3 3 2 Domain of unknown function (DUF4192) DUF3517 PF12030.8 CCF41145.1 - 0.0028 16.6 0.0 0.0054 15.7 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3517) HrpB1_HrpK PF09613.10 CCF41145.1 - 0.0082 15.8 1.0 4.2 7.0 0.0 3.9 3 1 1 4 4 4 1 Bacterial type III secretion protein (HrpB1_HrpK) Coatomer_WDAD PF04053.14 CCF41145.1 - 0.0082 15.2 0.0 0.021 13.9 0.0 1.6 1 0 0 1 1 1 1 Coatomer WD associated region TOM20_plant PF06552.12 CCF41145.1 - 0.03 14.1 3.2 69 3.1 0.0 4.9 5 0 0 5 5 5 0 Plant specific mitochondrial import receptor subunit TOM20 FAT PF02259.23 CCF41145.1 - 0.08 12.1 3.5 5.3 6.1 0.0 4.6 4 2 1 6 6 6 0 FAT domain Vta1_C PF18097.1 CCF41145.1 - 0.088 12.5 0.1 11 5.8 0.0 2.8 2 0 0 2 2 2 0 Vta1 C-terminal domain TPR_10 PF13374.6 CCF41145.1 - 0.29 11.1 17.5 23 5.0 0.0 7.4 9 0 0 9 9 8 0 Tetratricopeptide repeat SPO22 PF08631.10 CCF41145.1 - 2.3 7.6 11.0 15 5.0 0.0 5.5 5 2 3 8 8 8 0 Meiosis protein SPO22/ZIP4 like RskA PF10099.9 CCF41147.1 - 0.0091 16.3 4.6 0.0091 16.3 4.6 3.3 2 1 0 2 2 2 1 Anti-sigma-K factor rskA REGB_T4 PF10715.9 CCF41147.1 - 0.016 15.4 0.0 0.068 13.4 0.0 2.0 2 0 0 2 2 2 0 T4-page Endoribonuclease RegB DUF4179 PF13786.6 CCF41147.1 - 0.03 14.8 2.6 0.23 12.0 0.2 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4179) SANTA PF09133.10 CCF41147.1 - 0.065 13.7 0.3 0.28 11.7 0.3 2.1 1 0 0 1 1 1 0 SANTA (SANT Associated) SUIM_assoc PF16619.5 CCF41147.1 - 1 9.4 18.6 8.1 6.6 18.6 2.6 1 1 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 GFA PF04828.14 CCF41148.1 - 0.00037 20.8 0.7 0.00065 20.0 0.0 1.7 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme CN_hydrolase PF00795.22 CCF41149.1 - 1.6e-43 149.0 0.2 3.2e-43 147.9 0.0 1.6 2 1 0 2 2 2 1 Carbon-nitrogen hydrolase DNA_pol_A_exo1 PF01612.20 CCF41150.1 - 9.7e-05 22.1 0.0 0.00014 21.6 0.0 1.2 1 0 0 1 1 1 1 3'-5' exonuclease RNase_T PF00929.24 CCF41150.1 - 0.00016 22.2 0.0 0.00024 21.7 0.0 1.3 1 0 0 1 1 1 1 Exonuclease DUF5051 PF16473.5 CCF41150.1 - 0.0052 16.8 0.0 0.0077 16.2 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease, RNase T-like HET PF06985.11 CCF41151.1 - 1.4e-12 48.2 3.8 7.5e-10 39.3 0.6 2.3 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) PepX_C PF08530.10 CCF41154.1 - 9.6e-28 97.7 0.6 2.9e-25 89.5 0.6 2.2 1 1 0 1 1 1 1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain TPR_14 PF13428.6 CCF41155.1 - 1.8e-11 43.9 0.1 4.5e-06 27.0 0.1 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 CCF41155.1 - 3.2e-10 39.4 0.2 5.9e-06 26.1 0.0 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 CCF41155.1 - 3.5e-10 39.2 0.1 1e-05 25.2 0.1 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 CCF41155.1 - 1.4e-09 37.4 0.3 5.4e-06 26.0 0.0 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 CCF41155.1 - 9.8e-06 26.1 0.2 2.4e-05 24.9 0.2 1.6 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 CCF41155.1 - 1.1e-05 25.0 0.6 0.00049 19.7 0.2 2.3 1 1 1 2 2 2 1 TPR repeat TPR_12 PF13424.6 CCF41155.1 - 2.2e-05 24.6 0.7 6.8e-05 23.1 0.7 1.7 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_17 PF13431.6 CCF41155.1 - 4.7e-05 23.5 0.2 0.26 11.7 0.0 3.4 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 CCF41155.1 - 5.9e-05 23.5 0.4 0.00032 21.2 0.5 1.9 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_10 PF13374.6 CCF41155.1 - 0.00062 19.6 0.4 0.29 11.1 0.0 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 CCF41155.1 - 0.00091 19.7 0.2 0.05 14.3 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.6 CCF41155.1 - 0.0024 18.0 0.1 0.0036 17.4 0.1 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_15 PF13429.6 CCF41155.1 - 0.0029 16.9 0.1 0.004 16.4 0.1 1.2 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_7 PF13176.6 CCF41155.1 - 0.0044 17.0 0.1 4.3 7.6 0.0 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat ANAPC3 PF12895.7 CCF41155.1 - 0.0059 16.8 0.0 0.0081 16.4 0.0 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.6 CCF41155.1 - 0.0084 16.2 0.2 4.9 7.3 0.0 2.6 2 1 1 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat TPR_20 PF14561.6 CCF41155.1 - 0.032 14.5 0.4 0.051 13.9 0.4 1.2 1 0 0 1 1 1 0 Tetratricopeptide repeat Dioxygenase_N PF04444.14 CCF41155.1 - 0.079 12.8 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Catechol dioxygenase N terminus MIT PF04212.18 CCF41155.1 - 0.12 12.4 0.5 4.2 7.5 0.2 2.2 1 1 1 2 2 2 0 MIT (microtubule interacting and transport) domain RPN7 PF10602.9 CCF41155.1 - 0.14 11.8 0.0 0.17 11.6 0.0 1.1 1 0 0 1 1 1 0 26S proteasome subunit RPN7 GTP_EFTU PF00009.27 CCF41158.1 - 3.2e-46 157.3 0.0 4.8e-46 156.8 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFTUD2 PF16004.5 CCF41158.1 - 3.2e-33 114.9 3.9 7.6e-33 113.7 3.9 1.7 1 0 0 1 1 1 1 116 kDa U5 small nuclear ribonucleoprotein component N-terminus EFG_IV PF03764.18 CCF41158.1 - 1.9e-11 43.8 0.0 6.9e-11 42.0 0.0 2.0 2 0 0 2 2 2 1 Elongation factor G, domain IV GTP_EFTU_D2 PF03144.25 CCF41158.1 - 2.2e-09 37.6 0.0 7.9e-09 35.8 0.0 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 CCF41158.1 - 1.6e-08 34.5 0.2 3.6e-07 30.2 0.0 2.4 2 0 0 2 2 2 1 Elongation Factor G, domain II MMR_HSR1 PF01926.23 CCF41158.1 - 0.00036 20.6 0.1 0.00074 19.6 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Thiolase_N PF00108.23 CCF41159.1 - 1.2e-92 310.0 2.3 1.8e-92 309.4 2.3 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 CCF41159.1 - 3.4e-47 159.1 0.2 9.7e-47 157.7 0.2 1.8 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 CCF41159.1 - 5.6e-06 26.1 0.9 2e-05 24.3 0.7 2.1 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 CCF41159.1 - 0.32 10.9 3.8 5.4 6.9 0.1 2.8 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Sin3a_C PF16879.5 CCF41160.1 - 1.2e-76 258.2 3.8 2.1e-76 257.4 1.2 2.5 3 0 0 3 3 3 1 C-terminal domain of Sin3a protein PAH PF02671.21 CCF41160.1 - 8.7e-45 150.6 8.6 7e-18 64.5 2.8 4.4 3 1 1 4 4 4 3 Paired amphipathic helix repeat Sin3_corepress PF08295.12 CCF41160.1 - 1.2e-38 131.1 0.0 2.7e-38 130.0 0.0 1.6 1 0 0 1 1 1 1 Sin3 family co-repressor Nuf2 PF03800.14 CCF41160.1 - 0.11 12.7 1.8 1.5 9.0 0.0 3.3 4 0 0 4 4 4 0 Nuf2 family Fasciclin PF02469.22 CCF41161.1 - 4.2e-05 23.8 0.0 6.2e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 Fasciclin domain Linker_histone PF00538.19 CCF41162.1 - 2.9e-26 91.6 0.1 2.9e-26 91.6 0.1 2.1 2 0 0 2 2 2 1 linker histone H1 and H5 family ADH_N PF08240.12 CCF41163.1 - 2.4e-21 75.7 3.5 4.4e-21 74.8 3.5 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCF41163.1 - 5.5e-19 68.4 0.0 8.8e-19 67.8 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCF41163.1 - 4.5e-05 24.5 0.0 7.1e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 CCF41163.1 - 0.0076 15.6 0.3 0.012 15.0 0.3 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 CCF41163.1 - 0.13 11.5 0.1 0.21 10.9 0.1 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Fungal_trans_2 PF11951.8 CCF41164.1 - 9e-11 41.2 0.0 1.1e-10 40.8 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF41164.1 - 2.9e-08 33.7 10.7 4.6e-08 33.0 10.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Phosphoesterase PF04185.14 CCF41165.1 - 2.3e-21 76.4 0.1 3e-21 76.0 0.1 1.1 1 0 0 1 1 1 1 Phosphoesterase family Homeobox_KN PF05920.11 CCF41166.1 - 0.025 14.5 0.1 0.051 13.5 0.0 1.5 2 0 0 2 2 2 0 Homeobox KN domain IPP-2 PF04979.14 CCF41167.1 - 1.2e-24 87.6 10.4 1.2e-24 87.6 10.4 1.9 2 0 0 2 2 2 1 Protein phosphatase inhibitor 2 (IPP-2) Ssl1 PF04056.14 CCF41168.1 - 2.8e-73 245.8 0.0 3.7e-73 245.5 0.0 1.1 1 0 0 1 1 1 1 Ssl1-like C1_4 PF07975.12 CCF41168.1 - 3.4e-16 59.2 7.5 3.4e-16 59.2 7.5 2.9 2 2 0 2 2 2 1 TFIIH C1-like domain VWA_2 PF13519.6 CCF41168.1 - 3.8e-15 56.4 0.0 8.8e-15 55.3 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 CCF41168.1 - 0.002 18.4 0.0 0.0031 17.8 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain zinc_ribbon_15 PF17032.5 CCF41168.1 - 0.0064 17.2 1.9 0.0064 17.2 1.9 2.3 1 1 1 2 2 2 1 zinc-ribbon family HypA PF01155.19 CCF41168.1 - 0.87 9.6 9.3 1.1 9.4 0.7 2.6 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DZR PF12773.7 CCF41168.1 - 4 7.5 21.5 1.2 9.2 6.1 3.3 2 1 0 2 2 2 0 Double zinc ribbon Zn-ribbon_8 PF09723.10 CCF41168.1 - 5.4 7.2 15.8 5.1 7.3 5.3 3.0 2 0 0 2 2 2 0 Zinc ribbon domain COesterase PF00135.28 CCF41170.1 - 5.6e-81 272.9 0.0 3e-73 247.5 0.0 2.0 1 1 0 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.13 CCF41170.1 - 1.1e-11 45.0 0.1 1.7e-11 44.4 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold MFS_1 PF07690.16 CCF41171.1 - 1.3e-27 96.6 20.6 2.9e-27 95.5 20.2 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily CopD PF05425.13 CCF41171.1 - 0.2 12.1 0.0 0.2 12.1 0.0 3.7 4 0 0 4 4 4 0 Copper resistance protein D Aldo_ket_red PF00248.21 CCF41172.1 - 1.1e-60 205.3 0.0 1.3e-60 205.1 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family WD40 PF00400.32 CCF41173.1 - 5e-06 27.1 5.9 0.19 12.6 1.6 5.0 4 1 0 4 4 4 2 WD domain, G-beta repeat Ribosomal_L13 PF00572.18 CCF41174.1 - 0.0098 16.1 0.1 0.099 12.9 0.1 2.0 1 1 0 1 1 1 1 Ribosomal protein L13 BAG PF02179.16 CCF41175.1 - 1.4e-20 73.5 1.5 2.4e-20 72.7 1.5 1.4 1 0 0 1 1 1 1 BAG domain ubiquitin PF00240.23 CCF41175.1 - 5.8e-05 22.8 0.0 0.00012 21.7 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family Ubiquitin_5 PF18037.1 CCF41175.1 - 0.03 14.6 0.0 0.08 13.3 0.0 1.7 1 0 0 1 1 1 0 Ubiquitin-like domain Ubiquitin_4 PF18036.1 CCF41175.1 - 0.14 12.2 0.0 0.3 11.1 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-like domain Caps_synth_GfcC PF06251.11 CCF41175.1 - 0.18 11.4 0.9 4.3 6.9 0.2 2.2 2 0 0 2 2 2 0 Capsule biosynthesis GfcC RRM_1 PF00076.22 CCF41176.1 - 1.3e-21 76.2 0.0 1.4e-09 37.6 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PEX11 PF05648.14 CCF41177.1 - 3.7e-13 49.5 0.0 3.8e-13 49.4 0.0 1.0 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) Sugar_tr PF00083.24 CCF41180.1 - 0.0082 15.0 2.7 0.012 14.6 2.7 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter DUF202 PF02656.15 CCF41180.1 - 0.24 11.8 1.4 0.68 10.4 1.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF202) Peptidase_M18 PF02127.15 CCF41181.1 - 6.4e-173 575.5 0.0 1.3e-172 574.5 0.0 1.4 1 1 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.14 CCF41181.1 - 1.1e-05 24.6 0.1 0.0057 15.7 0.0 2.9 3 0 0 3 3 3 2 M42 glutamyl aminopeptidase His_Phos_1 PF00300.22 CCF41182.1 - 2.8e-07 30.4 1.2 0.15 11.7 0.0 4.2 3 1 1 4 4 4 4 Histidine phosphatase superfamily (branch 1) zf-CCHC PF00098.23 CCF41183.1 - 1.5e-18 66.0 18.3 4.8e-10 39.0 4.5 3.1 3 0 0 3 3 3 3 Zinc knuckle zf-CCHC_4 PF14392.6 CCF41183.1 - 3e-05 23.7 5.1 0.032 14.0 1.1 2.1 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_3 PF13917.6 CCF41183.1 - 0.00057 19.8 10.3 0.05 13.6 2.6 2.1 1 1 1 2 2 2 2 Zinc knuckle zf-CCHC_2 PF13696.6 CCF41183.1 - 0.0031 17.3 2.3 0.0031 17.3 2.3 3.0 3 1 0 3 3 3 2 Zinc knuckle Prim_Zn_Ribbon PF08273.12 CCF41183.1 - 0.012 15.9 8.1 0.012 15.9 8.1 1.7 1 1 1 2 2 2 0 Zinc-binding domain of primase-helicase zf-CCHC_5 PF14787.6 CCF41183.1 - 0.014 15.1 8.4 0.29 10.9 0.7 2.4 2 1 0 2 2 2 0 GAG-polyprotein viral zinc-finger zf-CCHC_6 PF15288.6 CCF41183.1 - 0.074 12.9 1.8 0.074 12.9 1.8 2.3 1 1 1 2 2 2 0 Zinc knuckle zf-C2H2_10 PF16588.5 CCF41183.1 - 0.31 10.8 0.4 0.31 10.8 0.4 2.4 2 0 0 2 2 2 0 C2H2 zinc-finger AFP PF02420.15 CCF41183.1 - 9.4 7.0 13.3 1.2 9.7 2.6 3.4 4 0 0 4 4 4 0 Insect antifreeze protein repeat Acyl-CoA_dh_1 PF00441.24 CCF41184.1 - 2.4e-34 118.7 1.0 3.6e-34 118.2 1.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Cyt-b5 PF00173.28 CCF41184.1 - 1.4e-19 69.9 0.1 3.4e-19 68.8 0.1 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Acyl-CoA_dh_M PF02770.19 CCF41184.1 - 4.2e-15 55.7 0.2 7e-15 55.0 0.2 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 CCF41184.1 - 6.7e-13 49.3 0.1 5.4e-12 46.4 0.0 2.3 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 CCF41184.1 - 4.9e-05 23.6 0.6 0.0001 22.6 0.0 1.7 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain DUF3666 PF12408.8 CCF41184.1 - 0.02 14.1 0.0 4.5 6.6 0.0 2.6 2 0 0 2 2 2 0 Ribose-5-phosphate isomerase PI31_Prot_N PF11566.8 CCF41185.1 - 3.1e-58 196.2 0.0 3.8e-58 195.9 0.0 1.1 1 0 0 1 1 1 1 PI31 proteasome regulator N-terminal PI31_Prot_C PF08577.11 CCF41185.1 - 3.4e-19 69.8 20.8 3.4e-19 69.8 20.8 2.7 3 1 0 3 3 3 1 PI31 proteasome regulator HORMA PF02301.18 CCF41186.1 - 4.1e-09 36.3 0.0 5.5e-09 35.9 0.0 1.1 1 0 0 1 1 1 1 HORMA domain DUF3455 PF11937.8 CCF41186.1 - 0.11 12.8 0.0 0.16 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3455) FA_desaturase PF00487.24 CCF41187.1 - 5.1e-16 59.3 16.0 5.1e-16 59.3 16.0 1.4 2 0 0 2 2 2 1 Fatty acid desaturase DUF3474 PF11960.8 CCF41187.1 - 0.00045 20.4 0.0 0.00087 19.5 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3474) Tannase PF07519.11 CCF41188.1 - 1.2e-24 87.1 0.0 1.3e-24 87.0 0.0 1.0 1 0 0 1 1 1 1 Tannase and feruloyl esterase Mito_carr PF00153.27 CCF41189.1 - 1.5e-19 69.7 5.5 5.1e-08 32.7 0.2 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein VIT1 PF01988.19 CCF41189.1 - 9.3 6.0 9.5 5.4 6.8 1.1 2.7 2 1 0 2 2 2 0 VIT family Acyl-CoA_dh_2 PF08028.11 CCF41190.1 - 8.9e-06 26.0 0.0 1.1e-05 25.8 0.0 1.1 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain UCH PF00443.29 CCF41191.1 - 7.5e-12 45.3 0.0 1.1e-11 44.7 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Rhodanese PF00581.20 CCF41191.1 - 2.3e-06 28.1 0.0 5.3e-06 26.9 0.0 1.6 1 0 0 1 1 1 1 Rhodanese-like domain FYTT PF07078.11 CCF41192.1 - 0.01 15.2 0.6 0.011 15.0 0.6 1.0 1 0 0 1 1 1 0 Forty-two-three protein Methyltransf_11 PF08241.12 CCF41193.1 - 0.00027 21.5 0.0 0.00082 20.0 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF41193.1 - 0.0051 17.5 0.0 0.013 16.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Ank_2 PF12796.7 CCF41194.1 - 5.5e-05 23.7 0.1 0.0017 18.9 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) F-box-like PF12937.7 CCF41194.1 - 0.00025 20.8 0.0 0.0005 19.9 0.0 1.5 1 0 0 1 1 1 1 F-box-like Ank_3 PF13606.6 CCF41194.1 - 0.001 19.4 0.4 0.092 13.3 0.0 3.0 3 0 0 3 3 3 1 Ankyrin repeat Ank_5 PF13857.6 CCF41194.1 - 0.0066 16.7 0.0 0.022 15.1 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 CCF41194.1 - 0.0081 16.7 0.2 0.12 12.9 0.1 2.8 2 1 1 3 3 3 1 Ankyrin repeats (many copies) DUF3742 PF12553.8 CCF41194.1 - 0.1 12.7 0.1 0.25 11.5 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3742) F-box_4 PF15966.5 CCF41194.1 - 0.14 12.0 0.0 0.35 10.8 0.0 1.7 1 0 0 1 1 1 0 F-box PKD_channel PF08016.12 CCF41197.1 - 5e-07 28.8 15.0 3.5e-05 22.7 15.0 2.4 1 1 0 1 1 1 1 Polycystin cation channel Ion_trans PF00520.31 CCF41197.1 - 1.5e-05 24.4 26.4 0.00021 20.6 22.8 2.6 2 1 0 2 2 2 1 Ion transport protein GLE1 PF07817.13 CCF41197.1 - 0.026 13.7 0.8 0.6 9.3 0.2 2.3 2 0 0 2 2 2 0 GLE1-like protein AP3D1 PF06375.11 CCF41197.1 - 0.81 9.9 5.7 1.4 9.1 5.7 1.4 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 MFS_1 PF07690.16 CCF41198.1 - 6.9e-32 110.7 27.8 6.9e-32 110.7 27.8 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily Phage_holin_2_4 PF16082.5 CCF41198.1 - 0.34 10.7 1.7 0.78 9.5 0.0 2.5 2 0 0 2 2 2 0 Bacteriophage holin family, superfamily II-like NAT PF04768.13 CCF41199.1 - 5.1e-49 166.2 0.0 7.2e-49 165.7 0.0 1.2 1 0 0 1 1 1 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase Semialdhyde_dh PF01118.24 CCF41199.1 - 2.1e-29 102.4 0.0 4.3e-29 101.4 0.0 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.20 CCF41199.1 - 0.024 14.8 0.0 0.054 13.6 0.0 1.6 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Sacchrp_dh_NADP PF03435.18 CCF41199.1 - 0.17 12.2 0.0 0.31 11.3 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Fasciclin PF02469.22 CCF41200.1 - 1e-10 41.9 0.1 2.1e-10 40.9 0.0 1.5 2 0 0 2 2 2 1 Fasciclin domain UNC-93 PF05978.16 CCF41202.1 - 3.2e-15 56.2 2.3 3.2e-15 56.2 2.3 2.8 3 0 0 3 3 3 1 Ion channel regulatory protein UNC-93 MFS_1 PF07690.16 CCF41202.1 - 6.3e-14 51.7 24.0 6.3e-14 51.7 24.0 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Glyco_hydro_16 PF00722.21 CCF41207.1 - 7.2e-12 45.1 0.5 1.7e-11 43.9 0.5 1.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 16 BfiI_DBD PF18243.1 CCF41207.1 - 0.11 12.1 0.1 0.29 10.7 0.1 1.7 2 0 0 2 2 2 0 Metal-independent restriction enzyme BfiI DNA binding domain MFS_1 PF07690.16 CCF41208.1 - 3.4e-39 134.8 17.4 3.4e-39 134.8 17.4 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 CCF41208.1 - 5.4e-06 25.1 4.0 8.3e-06 24.5 4.0 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) PsbI PF02532.14 CCF41208.1 - 0.052 13.5 0.7 0.052 13.5 0.7 2.3 2 0 0 2 2 2 0 Photosystem II reaction centre I protein (PSII 4.8 kDa protein) EphA2_TM PF14575.6 CCF41209.1 - 0.016 16.1 0.0 0.029 15.3 0.0 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Adeno_E3_CR2 PF02439.15 CCF41209.1 - 0.023 14.5 0.9 0.057 13.2 0.9 1.6 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 DUF5305 PF17231.2 CCF41209.1 - 0.029 13.8 6.9 0.088 12.2 6.9 1.7 1 1 0 1 1 1 0 Family of unknown function (DUF5305) TMEM154 PF15102.6 CCF41209.1 - 0.33 10.9 9.7 1 9.3 9.7 1.8 1 1 0 1 1 1 0 TMEM154 protein family Syndecan PF01034.20 CCF41209.1 - 0.41 10.6 2.4 0.75 9.8 2.4 1.3 1 0 0 1 1 1 0 Syndecan domain ABC_membrane PF00664.23 CCF41210.1 - 2.8e-52 178.1 19.3 3.5e-35 122.0 7.5 3.1 3 0 0 3 3 3 3 ABC transporter transmembrane region ABC_tran PF00005.27 CCF41210.1 - 1.3e-18 67.9 0.0 1.2e-14 55.0 0.0 2.4 2 0 0 2 2 2 2 ABC transporter AAA_29 PF13555.6 CCF41210.1 - 0.00033 20.3 0.3 0.23 11.2 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 CCF41210.1 - 0.00058 20.3 0.0 0.0095 16.3 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 CCF41210.1 - 0.0013 18.7 0.3 0.018 15.0 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_7 PF12775.7 CCF41210.1 - 0.023 14.2 0.7 0.038 13.5 0.0 1.6 2 0 0 2 2 2 0 P-loop containing dynein motor region DUF3377 PF11857.8 CCF41210.1 - 0.042 13.8 0.1 0.1 12.5 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) Rad17 PF03215.15 CCF41210.1 - 0.044 13.7 0.1 0.11 12.5 0.1 1.6 1 0 0 1 1 1 0 Rad17 P-loop domain TMEM43 PF07787.12 CCF41210.1 - 0.13 11.6 0.3 0.38 10.1 0.3 1.8 1 0 0 1 1 1 0 Transmembrane protein 43 AAA_5 PF07728.14 CCF41210.1 - 0.21 11.6 0.3 0.54 10.2 0.1 1.8 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_21 PF13304.6 CCF41210.1 - 0.26 11.0 0.1 1 9.1 0.1 2.0 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_33 PF13671.6 CCF41210.1 - 0.29 11.3 2.2 0.81 9.8 0.1 2.7 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 CCF41210.1 - 0.89 9.8 3.2 0.6 10.4 0.5 2.1 2 0 0 2 2 2 0 AAA domain Peptidase_U4 PF03419.13 CCF41210.1 - 7.1 5.8 9.5 2.1 7.6 1.2 2.5 2 0 0 2 2 2 0 Sporulation factor SpoIIGA Polysacc_synt_4 PF04669.13 CCF41211.1 - 1.4e-22 80.2 1.1 6e-21 74.9 1.1 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis DUF2491 PF10679.9 CCF41211.1 - 0.037 13.2 0.5 0.044 13.0 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2491) Folliculin PF11704.8 CCF41212.1 - 8.5 6.2 17.1 0.9 9.4 12.2 1.7 1 1 1 2 2 2 0 Vesicle coat protein involved in Golgi to plasma membrane transport Aa_trans PF01490.18 CCF41213.1 - 1.6e-71 241.2 32.8 1.9e-71 240.9 32.8 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Claudin_2 PF13903.6 CCF41213.1 - 0.0073 16.1 2.5 0.0073 16.1 2.5 2.7 3 0 0 3 3 3 1 PMP-22/EMP/MP20/Claudin tight junction PRIMA1 PF16101.5 CCF41215.1 - 0.061 13.4 1.4 0.61 10.1 1.2 2.1 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 DUF2841 PF11001.8 CCF41216.1 - 6.6e-44 148.9 7.1 9.6e-44 148.4 7.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2841) Sec34 PF04136.15 CCF41216.1 - 0.12 12.3 0.0 0.21 11.5 0.0 1.3 1 0 0 1 1 1 0 Sec34-like family Methyltransf_2 PF00891.18 CCF41218.1 - 2.3e-26 92.4 0.0 3.3e-26 91.9 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_25 PF13649.6 CCF41218.1 - 0.055 14.2 0.0 0.15 12.7 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain CVNH PF08881.10 CCF41221.1 - 7.3e-15 55.5 5.3 9.6e-11 42.3 0.7 1.5 1 1 1 2 2 2 2 CVNH domain Secretogranin_V PF05281.11 CCF41221.1 - 0.14 11.8 1.1 0.17 11.5 0.7 1.3 1 1 0 1 1 1 0 Neuroendocrine protein 7B2 precursor (Secretogranin V) DUF1158 PF06643.11 CCF41222.1 - 0.13 12.8 0.0 0.2 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1158) MFS_1 PF07690.16 CCF41224.1 - 1.4e-38 132.8 9.9 2.3e-38 132.1 9.9 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF41224.1 - 3.2e-08 32.9 6.3 3.2e-08 32.9 6.3 3.2 2 2 1 3 3 3 1 Sugar (and other) transporter MFS_3 PF05977.13 CCF41224.1 - 0.00076 18.0 4.4 0.00076 18.0 4.4 2.3 2 0 0 2 2 2 1 Transmembrane secretion effector MFS_1 PF07690.16 CCF41227.1 - 1.5e-29 103.1 32.2 2e-29 102.6 32.2 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF773 PF05600.12 CCF41229.1 - 0.043 12.6 0.1 0.14 10.8 0.0 1.7 2 0 0 2 2 2 0 CDK5 regulatory subunit-associated protein 3 Baculo_PEP_C PF04513.12 CCF41229.1 - 0.18 11.9 4.3 0.87 9.6 1.4 2.8 2 2 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Dicty_REP PF05086.12 CCF41231.1 - 1.5 6.7 6.1 2 6.3 6.1 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Glyco_hydro_72 PF03198.14 CCF41232.1 - 7.3e-117 390.1 0.2 8.8e-117 389.8 0.2 1.0 1 0 0 1 1 1 1 Glucanosyltransferase Cellulase PF00150.18 CCF41232.1 - 0.0051 16.3 0.0 0.061 12.8 0.0 2.1 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) BC10 PF06726.12 CCF41233.1 - 0.0025 18.0 0.2 0.0055 16.9 0.1 1.6 1 1 1 2 2 2 1 Bladder cancer-related protein BC10 Cyclase PF04199.13 CCF41234.1 - 4e-14 53.0 0.2 5.4e-14 52.6 0.2 1.2 1 0 0 1 1 1 1 Putative cyclase tRNA_synthFbeta PF17759.1 CCF41235.1 - 3.5e-47 160.6 0.0 5.3e-47 160.0 0.0 1.3 1 0 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain PhetRS_B1 PF18262.1 CCF41235.1 - 1.5e-31 108.4 0.3 1.2e-30 105.6 0.1 2.3 2 0 0 2 2 2 1 Phe-tRNA synthetase beta subunit B1 domain B3_4 PF03483.17 CCF41235.1 - 2.6e-27 95.6 0.0 4.2e-27 94.9 0.0 1.3 1 0 0 1 1 1 1 B3/4 domain B5 PF03484.15 CCF41235.1 - 2.7e-16 59.6 0.0 1.3e-13 51.0 0.0 2.6 2 0 0 2 2 2 2 tRNA synthetase B5 domain tRNA-synt_2d PF01409.20 CCF41235.1 - 0.17 11.3 0.0 16 4.9 0.0 2.2 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) DUF2256 PF10013.9 CCF41236.1 - 0.0058 16.7 2.5 1.4 9.1 0.4 2.4 2 0 0 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2256) FYVE PF01363.21 CCF41236.1 - 0.057 13.6 0.1 0.12 12.6 0.1 1.5 1 0 0 1 1 1 0 FYVE zinc finger DBR1 PF05011.13 CCF41238.1 - 0.042 14.3 0.0 0.11 12.9 0.0 1.7 1 0 0 1 1 1 0 Lariat debranching enzyme, C-terminal domain HPIH PF13323.6 CCF41239.1 - 0.069 13.0 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 N-terminal domain with HPIH motif Methyltransf_34 PF11312.8 CCF41241.1 - 3.9e-86 289.1 0.0 4.3e-86 288.9 0.0 1.1 1 0 0 1 1 1 1 Putative SAM-dependent methyltransferase Syja_N PF02383.18 CCF41242.1 - 6.5e-60 203.1 0.1 9.8e-60 202.5 0.1 1.3 1 0 0 1 1 1 1 SacI homology domain hSac2 PF12456.8 CCF41242.1 - 9.8e-41 138.1 0.0 1.8e-40 137.3 0.0 1.4 1 0 0 1 1 1 1 Inositol phosphatase DUF1428 PF07237.11 CCF41242.1 - 0.028 14.7 0.1 0.099 12.9 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1428) MFS_1 PF07690.16 CCF41245.1 - 2.3e-25 89.3 53.8 3.3e-16 59.2 23.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Pec_lyase_C PF00544.19 CCF41246.1 - 6.3e-44 150.1 5.8 9.6e-44 149.5 5.8 1.2 1 0 0 1 1 1 1 Pectate lyase Beta_helix PF13229.6 CCF41246.1 - 4.9e-05 23.2 4.8 0.0028 17.5 4.8 2.4 1 1 0 1 1 1 1 Right handed beta helix region Abhydrolase_1 PF00561.20 CCF41247.1 - 4.8e-13 49.3 0.1 6.5e-13 48.9 0.1 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CCF41247.1 - 0.00037 19.9 0.0 0.0024 17.2 0.0 2.1 2 1 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CCF41247.1 - 0.02 15.5 0.0 0.031 14.9 0.0 1.5 1 1 0 1 1 1 0 Alpha/beta hydrolase family HTH_psq PF05225.16 CCF41248.1 - 7.2e-11 41.7 0.0 1.6e-10 40.6 0.0 1.6 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.16 CCF41248.1 - 1.8e-08 34.2 0.0 4.5e-08 33.0 0.0 1.6 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_23 PF13384.6 CCF41248.1 - 0.0058 16.4 0.1 0.037 13.8 0.0 2.2 2 0 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.6 CCF41248.1 - 0.046 13.9 0.0 0.28 11.3 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain HSCB_C PF07743.13 CCF41251.1 - 2.3e-20 72.8 9.3 1.9e-19 69.9 6.5 2.2 2 0 0 2 2 2 1 HSCB C-terminal oligomerisation domain DnaJ PF00226.31 CCF41251.1 - 2.1e-07 30.9 0.4 5.1e-07 29.7 0.4 1.6 1 0 0 1 1 1 1 DnaJ domain ThiD2 PF17792.1 CCF41251.1 - 0.038 14.5 1.5 0.038 14.5 1.5 2.3 3 0 0 3 3 3 0 ThiD2 family FMN_dh PF01070.18 CCF41252.1 - 1.1e-110 369.9 0.0 1.4e-110 369.6 0.0 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 CCF41252.1 - 3.8e-19 68.6 0.0 1e-18 67.3 0.0 1.8 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.17 CCF41252.1 - 3.2e-07 29.8 0.1 5.1e-07 29.2 0.1 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 CCF41252.1 - 1.5e-05 24.2 0.2 3.8e-05 22.8 0.1 1.7 2 0 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain His_biosynth PF00977.21 CCF41252.1 - 0.014 14.9 0.0 0.024 14.1 0.0 1.3 1 0 0 1 1 1 0 Histidine biosynthesis protein NMO PF03060.15 CCF41252.1 - 0.025 14.0 0.2 0.038 13.4 0.2 1.2 1 0 0 1 1 1 0 Nitronate monooxygenase Ribul_P_3_epim PF00834.19 CCF41252.1 - 0.05 13.0 0.0 0.076 12.4 0.0 1.3 1 0 0 1 1 1 0 Ribulose-phosphate 3 epimerase family EHN PF06441.12 CCF41253.1 - 4.4e-31 107.4 0.3 6.7e-31 106.9 0.3 1.3 1 0 0 1 1 1 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 CCF41253.1 - 1.4e-08 34.7 0.1 2.2e-08 34.1 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Metallophos PF00149.28 CCF41254.1 - 3.4e-12 47.3 0.5 3.9e-12 47.1 0.5 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CCF41254.1 - 0.16 12.2 0.0 0.19 11.9 0.0 1.2 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain Cyclin PF08613.11 CCF41255.1 - 1.1e-06 29.0 0.0 1.1e-06 29.0 0.0 2.1 3 0 0 3 3 3 1 Cyclin Cyclin_N PF00134.23 CCF41255.1 - 0.019 14.7 0.1 0.044 13.5 0.1 1.7 1 1 0 1 1 1 0 Cyclin, N-terminal domain DUF1295 PF06966.12 CCF41256.1 - 4.5e-58 196.5 0.3 5.9e-58 196.2 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) Steroid_dh PF02544.16 CCF41256.1 - 7.5e-07 29.2 0.1 7.5e-07 29.2 0.1 2.8 1 1 1 3 3 3 1 3-oxo-5-alpha-steroid 4-dehydrogenase ICMT PF04140.14 CCF41256.1 - 4e-05 23.9 0.7 0.00063 20.1 0.0 2.7 2 1 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 CCF41256.1 - 0.00096 19.5 1.6 0.0035 17.7 0.0 2.7 2 1 1 3 3 3 1 Phospholipid methyltransferase ERG4_ERG24 PF01222.17 CCF41256.1 - 0.022 13.5 0.3 0.022 13.5 0.3 2.3 2 1 0 2 2 2 0 Ergosterol biosynthesis ERG4/ERG24 family DUF1056 PF06341.11 CCF41256.1 - 1.1 9.6 6.3 4.1 7.8 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1056) DUF4118 PF13493.6 CCF41256.1 - 1.4 8.8 10.0 1.4 8.7 4.9 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4118) GFA PF04828.14 CCF41257.1 - 1.1e-19 70.5 0.9 1.7e-19 70.0 0.9 1.2 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme Sugar_tr PF00083.24 CCF41258.1 - 1.7e-65 221.6 13.1 2e-65 221.4 13.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF41258.1 - 0.00015 20.8 27.3 0.00015 20.8 27.3 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily PEPCK_ATP PF01293.20 CCF41259.1 - 9.9e-192 637.7 0.0 1.1e-191 637.5 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase AAA_16 PF13191.6 CCF41259.1 - 0.09 13.1 0.0 0.14 12.5 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.6 CCF41259.1 - 0.14 12.3 0.1 0.25 11.5 0.1 1.4 1 0 0 1 1 1 0 AAA domain p450 PF00067.22 CCF41261.1 - 3.3e-51 174.5 0.0 4.4e-51 174.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 FixS PF03597.15 CCF41261.1 - 1.1 9.0 3.0 2.3 8.0 3.0 1.5 1 0 0 1 1 1 0 Cytochrome oxidase maturation protein cbb3-type Cupin_8 PF13621.6 CCF41262.1 - 2.2e-26 93.1 0.0 2.7e-26 92.8 0.0 1.2 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 CCF41262.1 - 0.0039 16.7 0.0 0.0095 15.4 0.0 1.7 2 0 0 2 2 2 1 Cupin superfamily protein JmjC PF02373.22 CCF41262.1 - 0.0054 17.2 0.0 0.072 13.5 0.0 2.5 2 1 0 2 2 2 1 JmjC domain, hydroxylase Cupin_2 PF07883.11 CCF41262.1 - 0.02 14.6 0.0 0.041 13.6 0.0 1.5 1 0 0 1 1 1 0 Cupin domain CK_II_beta PF01214.18 CCF41263.1 - 1.8e-74 249.5 0.0 3.8e-74 248.4 0.0 1.5 1 1 0 1 1 1 1 Casein kinase II regulatory subunit RRN3 PF05327.11 CCF41263.1 - 0.027 13.0 3.3 0.041 12.4 3.3 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 PRP38_assoc PF12871.7 CCF41263.1 - 1.7 9.3 21.5 3.9 8.1 4.3 2.2 2 0 0 2 2 2 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Spt5_N PF11942.8 CCF41263.1 - 3.1 8.8 19.9 0.3 12.1 9.3 2.5 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal Glyco_hydro_43 PF04616.14 CCF41264.1 - 9e-40 136.8 6.8 1.1e-39 136.5 6.8 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 PD40 PF07676.12 CCF41264.1 - 0.036 14.0 0.6 0.11 12.4 0.6 1.9 1 0 0 1 1 1 0 WD40-like Beta Propeller Repeat DUF2434 PF10361.9 CCF41265.1 - 4.7e-20 71.8 0.6 5.4e-20 71.6 0.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2434) Peptidase_M26_C PF07580.14 CCF41265.1 - 0.23 9.9 0.0 0.29 9.6 0.0 1.0 1 0 0 1 1 1 0 M26 IgA1-specific Metallo-endopeptidase C-terminal region COG5 PF10392.9 CCF41266.1 - 4.2e-40 137.0 0.9 4.2e-40 137.0 0.9 2.4 3 0 0 3 3 3 1 Golgi transport complex subunit 5 SRX PF09201.10 CCF41266.1 - 0.078 12.8 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 SRX, signal recognition particle receptor alpha subunit Pyr_redox_2 PF07992.14 CCF41267.1 - 1.7e-06 27.5 0.1 2.5e-06 26.9 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase MHYT PF03707.16 CCF41269.1 - 2.3e-17 62.9 20.4 1.4e-10 41.2 0.9 4.4 4 0 0 4 4 4 3 Bacterial signalling protein N terminal repeat DUF4131 PF13567.6 CCF41269.1 - 1.1 8.8 9.7 0.66 9.6 1.3 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) MFS_1 PF07690.16 CCF41270.1 - 3.4e-37 128.2 42.4 1.6e-36 126.0 27.2 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily MWFE PF15879.5 CCF41270.1 - 0.12 12.6 3.0 0.17 12.1 0.0 2.8 3 0 0 3 3 3 0 NADH-ubiquinone oxidoreductase MWFE subunit K_oxygenase PF13434.6 CCF41271.1 - 1.4e-81 274.4 0.0 1.7e-81 274.0 0.0 1.0 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 CCF41271.1 - 9.3e-06 25.1 0.0 1.6e-05 24.3 0.0 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCF41271.1 - 1.8e-05 24.2 0.0 4.6e-05 22.8 0.0 1.7 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CCF41271.1 - 0.0045 17.0 0.1 0.028 14.4 0.0 2.1 2 1 0 2 2 2 1 FAD-NAD(P)-binding FMO-like PF00743.19 CCF41271.1 - 0.23 9.8 0.0 0.31 9.4 0.0 1.1 1 0 0 1 1 1 0 Flavin-binding monooxygenase-like ABC2_membrane PF01061.24 CCF41272.1 - 6.1e-45 153.2 32.7 5.2e-39 133.8 25.8 2.7 3 0 0 3 3 3 2 ABC-2 type transporter PDR_CDR PF06422.12 CCF41272.1 - 3.8e-34 116.4 0.0 3.8e-34 116.4 0.0 2.9 3 0 0 3 3 3 1 CDR ABC transporter ABC_tran PF00005.27 CCF41272.1 - 4.9e-23 82.2 0.0 3.1e-16 60.1 0.0 3.4 3 0 0 3 3 3 2 ABC transporter ABC2_membrane_3 PF12698.7 CCF41272.1 - 5.2e-08 32.4 11.1 9.9e-08 31.5 11.1 1.4 1 0 0 1 1 1 1 ABC-2 family transporter protein AAA_25 PF13481.6 CCF41272.1 - 2.5e-05 24.0 0.0 5.1e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 CCF41272.1 - 3.3e-05 23.8 0.1 7.6e-05 22.7 0.1 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_18 PF13238.6 CCF41272.1 - 0.00067 20.2 0.0 0.0018 18.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CCF41272.1 - 0.00093 19.6 0.1 0.0026 18.1 0.1 1.8 1 0 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.6 CCF41272.1 - 0.0025 17.7 0.0 1.1 9.0 0.0 2.7 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_33 PF13671.6 CCF41272.1 - 0.005 17.0 0.1 0.014 15.6 0.1 1.8 1 0 0 1 1 1 1 AAA domain SMC_N PF02463.19 CCF41272.1 - 0.0061 16.0 0.0 0.51 9.7 0.0 2.5 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CCF41272.1 - 0.0089 15.8 0.1 0.02 14.6 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain cobW PF02492.19 CCF41272.1 - 0.081 12.5 0.1 0.15 11.7 0.1 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_17 PF13207.6 CCF41272.1 - 0.18 12.2 0.0 0.79 10.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain Syd PF07348.12 CCF41274.1 - 0.044 13.4 0.0 0.053 13.2 0.0 1.1 1 0 0 1 1 1 0 Syd protein (SUKH-2) LRR_4 PF12799.7 CCF41275.1 - 0.00074 19.9 0.0 0.31 11.5 0.1 3.2 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) F-box-like PF12937.7 CCF41275.1 - 0.0015 18.4 0.8 0.0048 16.7 0.3 2.2 2 1 0 2 2 2 1 F-box-like LRR_8 PF13855.6 CCF41275.1 - 0.0019 18.0 4.0 0.026 14.3 1.7 3.0 3 0 0 3 3 3 1 Leucine rich repeat BAR PF03114.18 CCF41276.1 - 3.4e-67 226.6 5.3 5e-67 226.0 5.3 1.2 1 0 0 1 1 1 1 BAR domain CP12 PF02672.15 CCF41276.1 - 0.0027 18.4 1.5 0.0085 16.8 0.0 2.5 3 1 0 3 3 3 1 CP12 domain FliD_N PF02465.18 CCF41276.1 - 2.9 8.7 7.1 2.3 9.0 2.3 2.6 2 1 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus Pept_tRNA_hydro PF01195.19 CCF41277.1 - 1.9e-26 93.1 0.0 2.2e-26 92.9 0.0 1.0 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase Acetyltransf_1 PF00583.25 CCF41278.1 - 1.1e-09 38.5 0.1 1.4e-09 38.1 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CCF41278.1 - 1.3e-06 28.3 0.1 1.7e-06 28.0 0.1 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CCF41278.1 - 0.0081 16.6 0.1 0.013 15.9 0.1 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain UCH PF00443.29 CCF41279.1 - 3e-47 161.3 0.0 4.9e-47 160.6 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CCF41279.1 - 9.6e-09 35.3 0.0 0.003 17.2 0.0 2.4 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase SAE2 PF08573.10 CCF41280.1 - 7.5e-36 123.6 0.0 7.5e-36 123.6 0.0 4.0 3 1 1 4 4 4 1 DNA repair protein endonuclease SAE2/CtIP C-terminus KIAA1430 PF13879.6 CCF41280.1 - 0.058 14.2 5.2 0.27 12.0 5.2 2.2 1 1 0 1 1 1 0 KIAA1430 homologue HALZ PF02183.18 CCF41280.1 - 0.46 10.7 8.5 5.7 7.2 1.9 2.8 2 0 0 2 2 2 0 Homeobox associated leucine zipper V_ATPase_I PF01496.19 CCF41280.1 - 0.91 7.4 5.8 1.4 6.8 5.8 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Ribosomal_S4 PF00163.19 CCF41280.1 - 0.93 10.4 8.7 1.5 9.8 4.4 3.2 1 1 1 2 2 2 0 Ribosomal protein S4/S9 N-terminal domain TMF_DNA_bd PF12329.8 CCF41280.1 - 9.7 6.3 20.4 0.08 13.0 7.8 3.2 2 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding zf-CCHC PF00098.23 CCF41283.1 - 9.2e-07 28.7 8.6 0.0003 20.7 0.9 2.2 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 CCF41283.1 - 0.06 13.1 1.8 0.81 9.5 0.1 2.2 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_6 PF15288.6 CCF41283.1 - 0.26 11.1 7.5 0.43 10.5 1.1 2.3 1 1 1 2 2 2 0 Zinc knuckle zf-ribbon_3 PF13248.6 CCF41283.1 - 0.53 9.8 6.7 0.59 9.6 0.7 2.7 1 1 2 3 3 3 0 zinc-ribbon domain Amidase PF01425.21 CCF41284.1 - 1e-67 229.1 0.2 1.1e-66 225.6 0.0 2.0 2 0 0 2 2 2 2 Amidase Herpes_capsid PF06112.11 CCF41286.1 - 0.97 9.5 15.0 1.1 9.3 15.0 1.1 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein AF-4 PF05110.13 CCF41286.1 - 2 6.4 19.0 1.8 6.5 19.0 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Macoilin PF09726.9 CCF41286.1 - 8.3 4.8 10.8 7.8 4.9 10.8 1.0 1 0 0 1 1 1 0 Macoilin family BOP1NT PF08145.12 CCF41287.1 - 9.4e-51 173.2 0.0 1.7e-50 172.4 0.0 1.4 1 0 0 1 1 1 1 BOP1NT (NUC169) domain FAD_binding_3 PF01494.19 CCF41288.1 - 7.8e-28 97.7 0.0 1.1e-27 97.2 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CCF41288.1 - 1.7e-06 27.5 0.4 0.0011 18.3 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCF41288.1 - 1.8e-06 27.8 0.7 0.0031 17.1 0.6 2.2 1 1 1 2 2 2 2 FAD dependent oxidoreductase Pyr_redox PF00070.27 CCF41288.1 - 1.3e-05 25.6 0.6 0.00032 21.2 0.2 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 CCF41288.1 - 4.6e-05 22.9 0.0 0.011 15.1 0.0 2.2 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CCF41288.1 - 0.00012 22.2 0.0 0.00038 20.6 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 CCF41288.1 - 0.0049 16.0 0.5 2.3 7.1 0.0 2.4 3 0 0 3 3 3 2 Lycopene cyclase protein Pyr_redox_3 PF13738.6 CCF41288.1 - 0.011 15.0 0.0 0.13 11.5 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 CCF41288.1 - 0.39 9.5 3.2 1.4 7.7 0.2 2.1 1 1 1 2 2 2 0 Tryptophan halogenase CUE PF02845.16 CCF41290.1 - 2.5e-06 27.1 0.1 4.4e-06 26.3 0.1 1.4 1 0 0 1 1 1 1 CUE domain NOA36 PF06524.12 CCF41290.1 - 0.64 9.3 5.5 1 8.6 5.5 1.2 1 0 0 1 1 1 0 NOA36 protein API5 PF05918.11 CCF41290.1 - 0.82 8.4 4.1 1.6 7.5 4.1 1.4 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) Rhabdo_matrix PF03397.14 CCF41291.1 - 0.033 14.0 0.0 0.056 13.2 0.0 1.3 1 0 0 1 1 1 0 Rhabdovirus matrix protein NCA2 PF08637.10 CCF41293.1 - 0.019 14.2 0.0 0.022 13.9 0.0 1.2 1 0 0 1 1 1 0 ATP synthase regulation protein NCA2 FMO-like PF00743.19 CCF41294.1 - 7.2e-26 90.7 0.0 4.1e-14 51.9 0.0 3.1 3 0 0 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 CCF41294.1 - 5.8e-13 48.8 0.5 4.4e-08 32.7 0.0 3.1 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CCF41294.1 - 5e-12 45.7 0.0 1e-09 38.0 0.0 2.5 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CCF41294.1 - 1.5e-10 40.8 0.5 1.7e-07 30.7 0.0 3.3 3 1 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 CCF41294.1 - 7.7e-08 32.5 0.7 0.00045 20.2 0.0 3.5 3 0 0 3 3 3 2 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 CCF41294.1 - 0.0012 19.1 1.3 0.0016 18.6 0.0 1.9 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 CCF41294.1 - 0.0024 17.1 0.1 0.033 13.4 0.0 2.1 2 0 0 2 2 2 1 Thi4 family DAO PF01266.24 CCF41294.1 - 0.0054 16.4 5.4 0.14 11.7 0.4 3.3 1 1 1 3 3 3 1 FAD dependent oxidoreductase Shikimate_DH PF01488.20 CCF41294.1 - 0.068 13.2 0.0 2.9 8.0 0.1 2.8 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase Semialdhyde_dh PF01118.24 CCF41294.1 - 0.14 12.6 0.0 0.95 9.9 0.0 2.3 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain UPF0149 PF03695.13 CCF41294.1 - 0.15 12.4 1.2 0.3 11.3 0.6 1.7 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0149) HCBP_related PF06594.11 CCF41294.1 - 0.5 10.3 2.9 7.4 6.6 2.9 2.5 1 1 0 1 1 1 0 Haemolysin-type calcium binding protein related domain Fungal_trans PF04082.18 CCF41296.1 - 2.2e-09 36.7 0.3 5.4e-09 35.5 0.3 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF41296.1 - 5.6e-05 23.2 7.3 0.00012 22.2 7.3 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Polysacc_deac_1 PF01522.21 CCF41297.1 - 7.3e-20 71.1 0.0 1.7e-19 69.9 0.0 1.6 1 0 0 1 1 1 1 Polysaccharide deacetylase DUF2334 PF10096.9 CCF41297.1 - 1.7e-05 24.6 0.1 4.7e-05 23.1 0.1 1.7 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2334) DUF2194 PF09960.9 CCF41297.1 - 0.062 11.6 0.0 0.077 11.3 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein conserved in bacteria (DUF2194) ADH_N PF08240.12 CCF41298.1 - 4.2e-21 74.9 0.1 8e-21 74.0 0.1 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCF41298.1 - 1.4e-16 60.7 0.2 3.6e-16 59.3 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase XdhC_C PF13478.6 CCF41298.1 - 0.0094 16.5 0.1 0.048 14.2 0.0 2.1 2 0 0 2 2 2 1 XdhC Rossmann domain 2-Hacid_dh_C PF02826.19 CCF41298.1 - 0.064 12.6 0.0 0.098 12.0 0.0 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Amidase PF01425.21 CCF41299.1 - 1.9e-90 304.0 0.0 2.4e-90 303.7 0.0 1.1 1 0 0 1 1 1 1 Amidase MSP1b PF03429.13 CCF41299.1 - 0.21 9.6 0.0 0.35 8.9 0.0 1.2 1 0 0 1 1 1 0 Major surface protein 1B adh_short_C2 PF13561.6 CCF41300.1 - 2.6e-60 203.9 0.2 3.2e-60 203.6 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF41300.1 - 1e-43 149.1 0.1 1.3e-43 148.7 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF41300.1 - 1.1e-07 32.0 0.1 1.8e-07 31.2 0.1 1.5 1 1 0 1 1 1 1 KR domain ThiF PF00899.21 CCF41300.1 - 0.0029 17.0 1.7 0.088 12.2 1.6 2.7 2 1 0 2 2 2 1 ThiF family Epimerase PF01370.21 CCF41300.1 - 0.02 14.4 0.1 0.097 12.1 0.1 2.0 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 CCF41300.1 - 0.021 14.0 0.0 0.031 13.4 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein DUF5448 PF17526.2 CCF41300.1 - 0.086 13.0 0.0 0.29 11.3 0.0 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5448) Fungal_trans PF04082.18 CCF41302.1 - 4.8e-16 58.6 0.0 7.9e-16 57.9 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain GATA PF00320.27 CCF41303.1 - 3e-15 55.5 3.5 4.8e-15 54.9 3.5 1.3 1 0 0 1 1 1 1 GATA zinc finger Ribosomal_S5_C PF03719.15 CCF41303.1 - 0.19 11.2 0.0 0.44 10.0 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein S5, C-terminal domain Aldo_ket_red PF00248.21 CCF41305.1 - 3.2e-30 105.3 0.0 4.9e-30 104.7 0.0 1.3 1 1 0 1 1 1 1 Aldo/keto reductase family IDO PF01231.18 CCF41306.1 - 7.1e-51 173.3 0.1 9.2e-51 173.0 0.1 1.1 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase INO80_Ies4 PF08193.11 CCF41309.1 - 0.00022 21.3 3.0 0.00022 21.3 3.0 2.0 2 0 0 2 2 2 1 INO80 complex subunit Ies4 SNF5 PF04855.12 CCF41309.1 - 0.0017 18.2 0.0 0.0031 17.4 0.0 1.4 1 0 0 1 1 1 1 SNF5 / SMARCB1 / INI1 Zn_clus PF00172.18 CCF41311.1 - 0.048 13.8 4.1 0.088 12.9 4.1 1.4 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2834 PF11196.8 CCF41312.1 - 2.2e-05 24.7 1.2 2.2e-05 24.7 1.2 3.4 3 1 0 3 3 3 1 Protein of unknown function (DUF2834) DUF1270 PF06900.11 CCF41312.1 - 0.14 12.6 1.6 0.81 10.1 0.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1270) Glyco_hydro_76 PF03663.14 CCF41314.1 - 1.2e-154 515.3 14.2 1.4e-154 515.0 14.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 CCF41314.1 - 0.0045 16.1 13.0 0.032 13.3 0.2 3.2 1 1 1 3 3 3 3 Glycosyl Hydrolase Family 88 Sugar_tr PF00083.24 CCF41315.1 - 1.6e-129 432.7 23.5 1.9e-129 432.5 23.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF41315.1 - 4.1e-29 101.6 60.2 5.3e-22 78.2 30.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily BT1 PF03092.16 CCF41315.1 - 0.0098 14.2 0.4 0.0098 14.2 0.4 2.6 2 1 0 2 2 2 2 BT1 family Sugar_tr PF00083.24 CCF41317.1 - 1.9e-06 27.0 1.7 2.1e-06 26.9 1.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF41317.1 - 0.012 14.5 0.0 0.013 14.4 0.0 1.1 1 0 0 1 1 1 0 Major Facilitator Superfamily DUF560 PF04575.13 CCF41317.1 - 0.18 11.3 0.1 0.24 10.8 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF560) Carb_anhydrase PF00194.21 CCF41318.1 - 5.5e-35 121.1 0.0 6.8e-35 120.8 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase UPF0164 PF03687.13 CCF41318.1 - 0.13 11.0 0.0 0.18 10.6 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0164) MFS_1 PF07690.16 CCF41319.1 - 6e-20 71.5 75.4 2.9e-15 56.1 44.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MDM31_MDM32 PF08118.11 CCF41321.1 - 4.3e-251 834.1 0.0 4.3e-251 834.1 0.0 1.3 2 0 0 2 2 2 1 Yeast mitochondrial distribution and morphology (MDM) proteins Sgf11 PF08209.11 CCF41323.1 - 0.023 14.2 3.1 0.023 14.2 3.1 1.7 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) DGCR6 PF07324.11 CCF41323.1 - 0.11 12.1 0.0 0.17 11.5 0.0 1.2 1 0 0 1 1 1 0 DiGeorge syndrome critical region 6 (DGCR6) protein zf_UBZ PF18439.1 CCF41323.1 - 0.2 11.3 2.1 1.9 8.1 0.3 2.3 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Coilin_N PF15862.5 CCF41323.1 - 3.4 7.5 7.7 0.23 11.3 1.8 2.1 2 0 0 2 2 2 0 Coilin N-terminus MFS_1 PF07690.16 CCF41325.1 - 1.6e-32 112.8 34.5 2.4e-31 108.9 30.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Spectrin_like PF18373.1 CCF41325.1 - 0.22 11.6 0.1 1.4 9.1 0.1 2.1 2 0 0 2 2 2 0 Spectrin like domain FBPase PF00316.20 CCF41326.1 - 1.1e-21 77.1 0.2 3e-21 75.8 0.2 1.6 1 1 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain PAP2 PF01569.21 CCF41327.1 - 2.3e-24 85.7 2.1 2.3e-24 85.7 2.1 1.7 2 0 0 2 2 2 1 PAP2 superfamily DUF983 PF06170.12 CCF41327.1 - 0.96 9.9 6.6 24 5.4 2.9 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF983) Sporozoite_P67 PF05642.11 CCF41328.1 - 9.8 4.1 9.9 11 4.0 9.9 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen p450 PF00067.22 CCF41329.1 - 2.5e-36 125.5 0.0 1.3e-27 96.7 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 2-Hacid_dh_C PF02826.19 CCF41330.1 - 1.2e-31 109.4 0.0 1.8e-30 105.6 0.0 2.2 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain adh_short PF00106.25 CCF41331.1 - 6.1e-36 123.7 0.2 7.4e-36 123.4 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF41331.1 - 1.7e-31 109.6 0.4 2.1e-31 109.3 0.4 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF41331.1 - 1.1e-10 41.8 0.2 3e-10 40.3 0.2 1.8 1 1 0 1 1 1 1 KR domain 3Beta_HSD PF01073.19 CCF41331.1 - 0.01 14.9 0.0 0.018 14.0 0.0 1.4 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Flu_PB1 PF00602.17 CCF41331.1 - 0.063 11.4 0.1 0.16 10.1 0.0 1.6 2 0 0 2 2 2 0 Influenza RNA-dependent RNA polymerase subunit PB1 Ras PF00071.22 CCF41332.1 - 4.5e-43 146.6 0.0 6.8e-43 146.1 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCF41332.1 - 3.9e-30 104.5 0.0 5.8e-30 104.0 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCF41332.1 - 1.1e-10 41.2 0.0 3.4e-10 39.7 0.0 1.7 2 0 0 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 CCF41332.1 - 0.00022 21.3 0.0 0.00041 20.4 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_33 PF13671.6 CCF41332.1 - 0.0036 17.5 0.0 0.006 16.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain Gtr1_RagA PF04670.12 CCF41332.1 - 0.009 15.4 0.0 0.012 15.0 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 CCF41332.1 - 0.017 15.1 0.0 0.067 13.1 0.0 2.0 1 1 0 2 2 2 0 RsgA GTPase AAA_28 PF13521.6 CCF41332.1 - 0.018 15.3 0.0 0.026 14.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain GTP_EFTU PF00009.27 CCF41332.1 - 0.019 14.5 0.0 0.12 11.9 0.0 2.3 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain SRPRB PF09439.10 CCF41332.1 - 0.042 13.3 0.0 0.064 12.7 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit PduV-EutP PF10662.9 CCF41332.1 - 0.048 13.4 0.0 1.3 8.8 0.0 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.6 CCF41332.1 - 0.064 13.5 0.0 0.11 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CCF41332.1 - 0.067 13.7 0.0 0.14 12.7 0.0 1.5 1 0 0 1 1 1 0 ABC transporter AAA_16 PF13191.6 CCF41332.1 - 0.1 13.0 0.0 0.18 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain Tropomodulin PF03250.14 CCF41332.1 - 0.16 12.0 0.0 0.27 11.3 0.0 1.3 1 0 0 1 1 1 0 Tropomodulin AAA_7 PF12775.7 CCF41332.1 - 0.17 11.4 0.0 0.27 10.7 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region Mannosidase_ig PF17786.1 CCF41333.1 - 1.1e-16 61.2 0.4 1.2e-15 57.8 0.1 2.7 2 0 0 2 2 2 1 Mannosidase Ig/CBM-like domain Glyco_hydro_2 PF00703.21 CCF41333.1 - 1.1e-13 51.8 0.1 3e-13 50.4 0.1 1.8 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 Ig_mannosidase PF17753.1 CCF41333.1 - 8.7e-07 28.6 0.0 2.4e-06 27.2 0.0 1.7 1 0 0 1 1 1 1 Ig-fold domain Glyco_hydro_2_N PF02837.18 CCF41333.1 - 0.00065 19.6 0.0 0.0028 17.6 0.0 2.0 2 0 0 2 2 2 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2_C PF02836.17 CCF41333.1 - 0.0021 17.2 0.3 0.0068 15.6 0.3 1.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain DUF3344 PF11824.8 CCF41333.1 - 0.16 11.6 1.5 3.5 7.2 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3344) Alg6_Alg8 PF03155.15 CCF41334.1 - 3.3e-177 590.3 25.9 3.8e-177 590.1 25.9 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family MerC PF03203.14 CCF41334.1 - 0.011 16.2 5.8 0.011 16.2 5.8 3.3 3 2 0 3 3 3 0 MerC mercury resistance protein Ank_2 PF12796.7 CCF41335.1 - 1.7e-60 201.6 3.1 1.1e-16 61.2 0.1 7.2 3 1 4 7 7 7 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CCF41335.1 - 1.4e-48 162.6 13.5 4.9e-12 46.1 0.0 8.7 2 1 7 9 9 9 7 Ankyrin repeats (many copies) Ank PF00023.30 CCF41335.1 - 1.8e-43 145.1 10.1 2.2e-08 34.2 0.1 11.4 12 0 0 12 12 12 7 Ankyrin repeat Ank_3 PF13606.6 CCF41335.1 - 4.8e-41 134.0 1.4 1.1e-05 25.5 0.0 10.4 11 0 0 11 11 11 6 Ankyrin repeat Ank_5 PF13857.6 CCF41335.1 - 2.7e-33 113.6 6.9 4.6e-09 36.4 0.1 7.3 2 1 6 8 8 7 6 Ankyrin repeats (many copies) VWA_3_C PF18571.1 CCF41335.1 - 0.0096 15.8 4.8 17 5.4 0.0 4.8 5 0 0 5 5 5 0 von Willebrand factor type A C-terminal domain HTH_Tnp_Tc5 PF03221.16 CCF41335.1 - 0.019 15.0 0.2 9 6.4 0.0 4.3 3 1 1 4 4 4 0 Tc5 transposase DNA-binding domain TniB PF05621.11 CCF41335.1 - 0.098 12.1 0.3 0.18 11.2 0.3 1.4 1 0 0 1 1 1 0 Bacterial TniB protein Yqai PF09466.10 CCF41335.1 - 0.17 12.2 5.1 87 3.5 0.1 4.3 2 1 1 3 3 3 0 Hypothetical protein Yqai C1_2 PF03107.16 CCF41335.1 - 0.19 12.1 7.2 0.36 11.2 7.2 1.4 1 0 0 1 1 1 0 C1 domain RVP PF00077.20 CCF41335.1 - 0.34 11.2 1.2 50 4.3 0.0 3.2 1 1 2 3 3 3 0 Retroviral aspartyl protease zf-UBR PF02207.20 CCF41335.1 - 0.37 11.0 10.8 0.032 14.4 5.9 1.7 2 0 0 2 2 2 0 Putative zinc finger in N-recognin (UBR box) Mit_KHE1 PF10173.9 CCF41336.1 - 7.7e-62 208.8 0.0 7.7e-62 208.8 0.0 1.6 2 0 0 2 2 2 1 Mitochondrial K+-H+ exchange-related DUF4471 PF14740.6 CCF41336.1 - 0.37 10.0 3.7 0.53 9.4 3.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) DDE_1 PF03184.19 CCF41338.1 - 8.8e-35 119.9 0.0 1.8e-34 118.9 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 CCF41338.1 - 3.6e-10 39.7 0.1 8.7e-10 38.5 0.1 1.7 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 CCF41338.1 - 6.2e-08 32.3 0.1 1.2e-07 31.4 0.1 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain DDE_3 PF13358.6 CCF41338.1 - 7.3e-05 22.5 0.0 0.00024 20.9 0.0 1.9 1 1 0 1 1 1 1 DDE superfamily endonuclease HTH_28 PF13518.6 CCF41338.1 - 0.0099 16.0 1.0 0.021 14.9 0.2 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_7 PF02796.15 CCF41338.1 - 0.016 15.3 0.6 0.037 14.1 0.6 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase HTH_23 PF13384.6 CCF41338.1 - 0.024 14.4 1.0 0.052 13.3 0.1 2.0 2 0 0 2 2 2 0 Homeodomain-like domain HTH_Tnp_IS630 PF01710.16 CCF41338.1 - 0.064 13.3 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 Transposase HTH_Tnp_ISL3 PF13542.6 CCF41338.1 - 0.14 11.6 0.0 0.33 10.4 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 Zn_clus PF00172.18 CCF41339.1 - 0.00041 20.4 12.8 0.00041 20.4 12.8 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-C2H2 PF00096.26 CCF41339.1 - 0.0042 17.5 0.3 0.0042 17.5 0.3 2.2 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-met PF12874.7 CCF41339.1 - 0.0087 16.4 0.2 0.019 15.4 0.2 1.6 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 CCF41339.1 - 0.04 14.2 0.1 0.077 13.3 0.1 1.5 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding Cation_efflux PF01545.21 CCF41341.1 - 9.1e-50 169.2 6.1 1.2e-49 168.8 6.1 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 CCF41341.1 - 2.1e-05 24.5 0.1 4.8e-05 23.4 0.1 1.6 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter DJ-1_PfpI PF01965.24 CCF41342.1 - 3.3e-15 56.3 0.0 4.2e-15 55.9 0.0 1.1 1 0 0 1 1 1 1 DJ-1/PfpI family ABC_tran PF00005.27 CCF41343.1 - 2.1e-51 174.0 0.0 1.8e-30 106.3 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 CCF41343.1 - 1.2e-45 156.3 22.1 1.7e-26 93.5 8.6 3.2 2 1 1 3 3 3 3 ABC transporter transmembrane region AAA_29 PF13555.6 CCF41343.1 - 1.3e-08 34.4 0.1 0.0027 17.4 0.0 3.1 3 0 0 3 3 3 2 P-loop containing region of AAA domain SMC_N PF02463.19 CCF41343.1 - 4.1e-08 32.9 1.1 0.0008 18.9 0.0 3.3 2 1 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 CCF41343.1 - 4.8e-07 30.3 1.0 0.034 14.5 1.3 3.0 2 1 0 2 2 2 2 AAA ATPase domain AAA_30 PF13604.6 CCF41343.1 - 1.4e-06 28.1 0.3 0.049 13.3 0.0 3.6 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.6 CCF41343.1 - 2.3e-06 27.9 0.1 0.061 13.6 0.0 3.2 2 1 0 2 2 2 2 AAA domain APS_kinase PF01583.20 CCF41343.1 - 3.6e-06 26.9 0.1 0.0032 17.4 0.0 2.5 2 0 0 2 2 2 2 Adenylylsulphate kinase RsgA_GTPase PF03193.16 CCF41343.1 - 5e-06 26.5 0.0 0.017 15.0 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase Zeta_toxin PF06414.12 CCF41343.1 - 5.3e-06 25.9 0.0 0.085 12.1 0.0 2.7 2 0 0 2 2 2 2 Zeta toxin AAA_21 PF13304.6 CCF41343.1 - 6.1e-06 26.3 0.2 1.1 9.0 0.0 3.3 2 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_18 PF13238.6 CCF41343.1 - 5.5e-05 23.7 0.0 0.26 11.8 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_23 PF13476.6 CCF41343.1 - 6.7e-05 23.5 0.2 0.28 11.6 0.0 2.8 3 0 0 3 3 2 2 AAA domain DUF87 PF01935.17 CCF41343.1 - 0.00011 22.4 0.0 0.17 11.9 0.0 2.7 3 0 0 3 3 2 2 Helicase HerA, central domain AAA_33 PF13671.6 CCF41343.1 - 0.00019 21.6 0.0 0.2 11.8 0.0 2.8 2 0 0 2 2 2 1 AAA domain DUF3987 PF13148.6 CCF41343.1 - 0.00034 19.8 0.0 0.71 8.8 0.0 2.8 2 0 0 2 2 2 2 Protein of unknown function (DUF3987) AAA_25 PF13481.6 CCF41343.1 - 0.00038 20.1 0.1 0.46 10.0 0.0 3.4 3 0 0 3 3 3 1 AAA domain AAA_5 PF07728.14 CCF41343.1 - 0.0043 17.1 0.2 9.2 6.3 0.0 3.6 4 0 0 4 4 4 0 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 CCF41343.1 - 0.0063 16.3 0.0 3.6 7.2 0.0 3.0 2 1 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 CCF41343.1 - 0.007 16.4 0.1 1.9 8.6 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA PF00004.29 CCF41343.1 - 0.015 15.7 0.0 65 4.0 0.0 3.5 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) SRP54 PF00448.22 CCF41343.1 - 0.018 14.7 0.0 0.55 9.8 0.0 2.5 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain G-alpha PF00503.20 CCF41343.1 - 0.028 13.6 0.0 4.6 6.3 0.0 2.2 2 0 0 2 2 2 0 G-protein alpha subunit ABC_ATPase PF09818.9 CCF41343.1 - 0.034 12.9 0.2 0.066 12.0 0.2 1.4 1 0 0 1 1 1 0 Predicted ATPase of the ABC class AAA_17 PF13207.6 CCF41343.1 - 0.036 14.5 3.4 4.3 7.8 0.0 3.3 4 0 0 4 4 3 0 AAA domain Cytidylate_kin PF02224.18 CCF41343.1 - 0.044 13.5 0.5 12 5.5 0.0 2.9 3 0 0 3 3 3 0 Cytidylate kinase RNA_helicase PF00910.22 CCF41343.1 - 0.045 14.1 0.1 9.3 6.7 0.0 3.1 3 0 0 3 3 2 0 RNA helicase NB-ARC PF00931.22 CCF41343.1 - 0.074 12.2 0.0 9.6 5.3 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain AAA_15 PF13175.6 CCF41343.1 - 0.14 11.8 0.0 4.1 7.0 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain CDC45 PF02724.14 CCF41343.1 - 3.6 5.8 6.8 6.1 5.0 6.8 1.3 1 0 0 1 1 1 0 CDC45-like protein UvrD-helicase PF00580.21 CCF41346.1 - 4.6e-65 220.2 0.1 3.7e-63 214.0 0.1 2.4 1 1 0 1 1 1 1 UvrD/REP helicase N-terminal domain UvrD_C PF13361.6 CCF41346.1 - 6.1e-64 216.6 0.0 7.2e-63 213.1 0.0 2.0 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 CCF41346.1 - 2.2e-31 109.1 0.0 4.7e-31 108.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 CCF41346.1 - 1.4e-14 53.7 0.0 2.8e-14 52.7 0.0 1.6 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_30 PF13604.6 CCF41346.1 - 6.3e-08 32.6 0.6 0.00074 19.3 0.2 2.4 2 0 0 2 2 2 2 AAA domain Viral_helicase1 PF01443.18 CCF41346.1 - 5.3e-05 23.1 0.0 0.69 9.6 0.0 3.2 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_12 PF13087.6 CCF41346.1 - 0.0013 18.4 0.0 0.017 14.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 CCF41346.1 - 0.029 14.2 0.1 0.11 12.2 0.1 2.0 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 CCF41346.1 - 0.86 10.0 2.8 4.1 7.7 0.6 3.1 2 2 0 2 2 2 0 AAA ATPase domain NPC1_N PF16414.5 CCF41347.1 - 5.5e-84 281.5 9.8 7.5e-84 281.1 9.8 1.2 1 0 0 1 1 1 1 Niemann-Pick C1 N terminus Patched PF02460.18 CCF41347.1 - 4.5e-62 210.3 20.4 2.2e-47 161.7 0.9 3.2 3 0 0 3 3 3 3 Patched family Sterol-sensing PF12349.8 CCF41347.1 - 9.4e-52 174.9 6.2 9.4e-52 174.9 6.2 3.3 3 0 0 3 3 3 1 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.15 CCF41347.1 - 5.2e-05 22.3 8.1 5.2e-05 22.3 8.1 3.0 3 0 0 3 3 3 2 MMPL family Folate_rec PF03024.14 CCF41347.1 - 7.7e-05 22.6 2.1 0.00017 21.5 2.1 1.5 1 0 0 1 1 1 1 Folate receptor family PAS_9 PF13426.7 CCF41349.1 - 9.6e-14 51.5 0.0 1.6e-12 47.6 0.0 2.4 2 0 0 2 2 2 1 PAS domain PAS PF00989.25 CCF41349.1 - 0.002 18.1 0.0 0.0082 16.1 0.0 2.0 2 0 0 2 2 2 1 PAS fold PAS_4 PF08448.10 CCF41349.1 - 0.036 14.3 0.0 0.44 10.8 0.0 2.4 2 0 0 2 2 2 0 PAS fold DHHC PF01529.20 CCF41351.1 - 5.4e-27 94.5 0.8 5.4e-27 94.5 0.8 2.1 2 0 0 2 2 2 1 DHHC palmitoyltransferase Methyltransf_23 PF13489.6 CCF41352.1 - 3.5e-07 30.2 0.0 3.9e-07 30.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF41352.1 - 0.042 14.6 0.0 0.071 13.9 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 CCF41352.1 - 0.21 12.3 0.0 0.41 11.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 CCF41354.1 - 1.3e-12 47.9 0.0 1.4e-12 47.7 0.0 1.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF41354.1 - 5e-08 33.5 0.0 9.8e-08 32.6 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF41354.1 - 1e-05 25.4 0.0 0.00011 22.1 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF41354.1 - 0.00042 21.0 0.0 0.003 18.3 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 CCF41354.1 - 0.0011 19.1 0.0 0.0013 18.9 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase MTS PF05175.14 CCF41354.1 - 0.0021 17.6 0.0 0.0022 17.5 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.17 CCF41354.1 - 0.0025 17.3 0.0 0.0033 16.9 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_11 PF08241.12 CCF41354.1 - 0.0065 17.1 0.0 0.011 16.4 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 CCF41354.1 - 0.011 15.4 0.1 0.12 12.1 0.1 1.9 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_16 PF10294.9 CCF41354.1 - 0.042 13.6 0.0 0.05 13.3 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_2 PF00891.18 CCF41354.1 - 0.074 12.3 0.0 0.091 12.0 0.0 1.1 1 0 0 1 1 1 0 O-methyltransferase domain PrmA PF06325.13 CCF41354.1 - 0.15 11.4 0.0 0.15 11.4 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Bac_export_2 PF01312.19 CCF41355.1 - 0.095 11.9 1.5 0.14 11.4 1.5 1.3 1 0 0 1 1 1 0 FlhB HrpN YscU SpaS Family DUF4118 PF13493.6 CCF41355.1 - 2.4 8.0 12.5 0.045 13.5 4.0 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4118) Fungal_trans PF04082.18 CCF41356.1 - 0.0006 18.9 0.0 0.00093 18.3 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Polysacc_deac_1 PF01522.21 CCF41357.1 - 4.1e-11 42.9 0.0 6.4e-11 42.2 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase AltA1 PF16541.5 CCF41358.1 - 0.037 14.9 0.0 0.05 14.5 0.0 1.3 1 0 0 1 1 1 0 Alternaria alternata allergen 1 Helo_like_N PF17111.5 CCF41359.1 - 1.2e-07 31.3 0.1 1.5e-07 31.0 0.1 1.1 1 0 0 1 1 1 1 Fungal N-terminal domain of STAND proteins HTH_20 PF12840.7 CCF41361.1 - 0.16 12.1 0.6 4.8 7.3 0.6 2.4 1 1 0 1 1 1 0 Helix-turn-helix domain E1-E2_ATPase PF00122.20 CCF41362.1 - 4e-49 166.6 4.4 4e-49 166.6 4.4 2.6 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 CCF41362.1 - 2.4e-17 63.9 0.1 7.4e-17 62.3 0.1 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 CCF41362.1 - 0.0019 18.0 0.1 0.0036 17.1 0.1 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CCF41362.1 - 0.024 14.7 0.0 0.046 13.8 0.0 1.4 1 0 0 1 1 1 0 Cation transport ATPase (P-type) O-antigen_lig PF13425.6 CCF41362.1 - 4.6 5.9 12.3 0.1 11.4 5.0 1.8 2 0 0 2 2 2 0 O-antigen ligase like membrane protein DUF2613 PF11021.8 CCF41362.1 - 9.3 6.5 8.4 14 5.9 0.6 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2613) ABM PF03992.16 CCF41363.1 - 0.00025 21.1 0.2 0.00034 20.7 0.2 1.3 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase DUF3425 PF11905.8 CCF41365.1 - 2e-20 73.0 1.3 2.9e-20 72.5 1.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) bZIP_1 PF00170.21 CCF41365.1 - 0.0079 16.3 10.6 0.014 15.5 7.7 2.2 1 1 1 2 2 2 1 bZIP transcription factor Metal_resist PF13801.6 CCF41365.1 - 0.0085 16.3 7.4 0.02 15.1 7.4 1.6 1 0 0 1 1 1 1 Heavy-metal resistance M PF02370.16 CCF41365.1 - 0.07 13.7 3.7 1.9 9.3 0.6 2.8 2 0 0 2 2 2 0 M protein repeat TPR_21 PF09976.9 CCF41365.1 - 0.16 11.7 1.9 0.25 11.1 1.9 1.2 1 0 0 1 1 1 0 Tetratricopeptide repeat-like domain COG5 PF10392.9 CCF41365.1 - 0.23 11.6 1.3 0.41 10.8 1.3 1.3 1 0 0 1 1 1 0 Golgi transport complex subunit 5 Atg14 PF10186.9 CCF41365.1 - 3.2 6.8 5.2 5 6.1 5.2 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 bZIP_2 PF07716.15 CCF41365.1 - 6.8 6.9 12.9 1.1 9.5 6.5 2.3 2 0 0 2 2 2 0 Basic region leucine zipper Spindle_Spc25 PF08234.12 CCF41366.1 - 4.3e-26 90.9 0.1 1.1e-25 89.6 0.1 1.8 1 0 0 1 1 1 1 Chromosome segregation protein Spc25 Atg14 PF10186.9 CCF41366.1 - 0.052 12.6 13.1 0.1 11.7 13.1 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4407 PF14362.6 CCF41366.1 - 0.094 12.1 10.7 0.12 11.7 10.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) PdxA PF04166.12 CCF41366.1 - 0.26 10.7 3.5 0.32 10.4 3.5 1.3 1 1 0 1 1 1 0 Pyridoxal phosphate biosynthetic protein PdxA Tau95 PF09734.9 CCF41366.1 - 0.28 12.0 4.6 0.59 10.9 3.9 1.8 2 0 0 2 2 2 0 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain FapA PF03961.13 CCF41366.1 - 0.49 9.0 7.6 0.67 8.5 7.6 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A TPR_MLP1_2 PF07926.12 CCF41366.1 - 2.5 8.2 22.5 10 6.2 22.3 2.0 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Tho2 PF11262.8 CCF41366.1 - 5.4 6.1 12.4 9.9 5.3 12.4 1.5 1 1 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 Bap31_Bap29_C PF18035.1 CCF41366.1 - 5.4 7.1 12.3 99 3.1 12.3 2.8 1 1 0 1 1 1 0 Bap31/Bap29 cytoplasmic coiled-coil domain HTH_psq PF05225.16 CCF41367.1 - 3.4e-11 42.7 0.0 5.7e-11 42.0 0.0 1.4 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.16 CCF41367.1 - 1e-09 38.3 0.1 1.8e-09 37.5 0.1 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain O-FucT PF10250.9 CCF41368.1 - 3.9e-10 40.0 0.0 9.3e-10 38.7 0.0 1.5 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase Acyl-CoA_dh_1 PF00441.24 CCF41370.1 - 2.4e-05 24.6 0.1 2.6e-05 24.5 0.1 1.1 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Sec63 PF02889.16 CCF41371.1 - 1.1e-10 41.2 0.0 2e-09 37.0 0.0 2.1 1 1 0 1 1 1 1 Sec63 Brl domain Gelsolin PF00626.22 CCF41372.1 - 8.8e-10 38.3 0.0 0.0023 17.8 0.0 3.2 3 1 0 3 3 3 2 Gelsolin repeat AAR2 PF05282.11 CCF41373.1 - 7.5e-52 176.9 0.0 1.4e-51 176.0 0.0 1.4 1 1 0 1 1 1 1 AAR2 protein UPF0524 PF15823.5 CCF41373.1 - 0.066 12.6 0.1 0.12 11.7 0.1 1.3 1 0 0 1 1 1 0 UPF0524 of C3orf70 MINDY_DUB PF04424.13 CCF41374.1 - 8.6e-23 80.6 0.0 1.4e-22 79.9 0.0 1.3 1 0 0 1 1 1 1 MINDY deubiquitinase MFS_1 PF07690.16 CCF41375.1 - 8.6e-14 51.2 12.1 8.6e-14 51.2 12.1 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3328 PF11807.8 CCF41376.1 - 6.3e-10 39.2 0.5 2.1e-08 34.2 0.1 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF3328) 2OG-FeII_Oxy PF03171.20 CCF41378.1 - 6.7e-14 52.2 0.0 1.3e-13 51.3 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 CCF41378.1 - 0.039 14.7 0.0 0.079 13.7 0.0 1.5 1 0 0 1 1 1 0 non-haem dioxygenase in morphine synthesis N-terminal CNH PF00780.22 CCF41379.1 - 4e-24 85.7 0.0 5e-24 85.4 0.0 1.1 1 0 0 1 1 1 1 CNH domain MFS_1 PF07690.16 CCF41380.1 - 6.4e-18 64.8 26.3 6.4e-18 64.8 26.3 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily NUDIX PF00293.28 CCF41381.1 - 9.2e-16 58.1 0.7 1.4e-15 57.5 0.2 1.5 2 0 0 2 2 2 1 NUDIX domain NUDIX PF00293.28 CCF41382.1 - 3.7e-07 30.3 0.0 5.9e-07 29.6 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain Abhydrolase_1 PF00561.20 CCF41383.1 - 4.1e-48 164.3 0.0 1.8e-47 162.2 0.0 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Esterase PF00756.20 CCF41383.1 - 0.0004 20.1 0.0 0.00067 19.4 0.0 1.3 1 0 0 1 1 1 1 Putative esterase zf-RING_6 PF14835.6 CCF41383.1 - 0.094 12.6 0.1 0.23 11.4 0.1 1.6 1 0 0 1 1 1 0 zf-RING of BARD1-type protein IFP_35_N PF07334.13 CCF41385.1 - 0.052 13.6 0.6 0.083 13.0 0.6 1.4 1 0 0 1 1 1 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus EVI2A PF05399.11 CCF41386.1 - 0.18 11.3 0.3 0.25 10.9 0.3 1.1 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) WD40 PF00400.32 CCF41387.1 - 0.0025 18.6 2.9 0.22 12.5 0.1 4.2 4 0 0 4 4 4 1 WD domain, G-beta repeat VRP3 PF03536.15 CCF41387.1 - 0.092 12.2 0.0 0.21 11.1 0.0 1.5 1 0 0 1 1 1 0 Salmonella virulence-associated 28kDa protein p450 PF00067.22 CCF41389.1 - 1.2e-24 86.9 0.0 1.4e-24 86.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Phage_Treg PF04761.12 CCF41389.1 - 0.051 13.7 0.0 0.12 12.5 0.0 1.6 1 0 0 1 1 1 0 Lactococcus bacteriophage putative transcription regulator AA_permease_2 PF13520.6 CCF41390.1 - 1e-19 70.7 3.2 1.3e-19 70.4 3.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CCF41390.1 - 2.8e-10 39.4 2.1 3.5e-10 39.1 2.1 1.0 1 0 0 1 1 1 1 Amino acid permease peroxidase PF00141.23 CCF41391.1 - 2.5e-83 279.3 0.0 1.1e-43 149.6 0.0 2.3 2 0 0 2 2 2 2 Peroxidase GST_C_3 PF14497.6 CCF41391.1 - 0.048 13.8 0.0 17 5.7 0.0 2.5 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain Myb_DNA-binding PF00249.31 CCF41392.1 - 0.00089 19.4 0.2 0.017 15.3 0.1 2.4 2 0 0 2 2 2 1 Myb-like DNA-binding domain AIM24 PF01987.17 CCF41393.1 - 4e-49 167.2 0.9 4.5e-49 167.0 0.9 1.0 1 0 0 1 1 1 1 Mitochondrial biogenesis AIM24 Helicase_C PF00271.31 CCF41395.1 - 6.4e-09 36.2 0.0 1.6e-08 34.9 0.0 1.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain PHP_C PF13263.6 CCF41395.1 - 0.14 11.9 0.0 0.24 11.2 0.0 1.3 1 0 0 1 1 1 0 PHP-associated SH3_1 PF00018.28 CCF41396.1 - 0.00018 21.0 0.1 0.0004 19.9 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 CCF41396.1 - 0.00052 19.8 0.1 0.00096 19.0 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain CYYR1 PF10873.8 CCF41396.1 - 8.5 6.8 10.1 0.16 12.4 1.4 2.4 1 1 1 2 2 2 0 Cysteine and tyrosine-rich protein 1 Pkinase PF00069.25 CCF41397.1 - 1.3e-19 70.7 0.0 2e-19 70.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain HEAT PF02985.22 CCF41397.1 - 4.7e-13 48.2 9.0 0.027 14.7 0.1 6.7 6 0 0 6 6 6 3 HEAT repeat WD40 PF00400.32 CCF41397.1 - 1.3e-09 38.4 19.2 1.4e-06 28.9 0.1 6.3 6 0 0 6 6 6 2 WD domain, G-beta repeat HEAT_2 PF13646.6 CCF41397.1 - 2.4e-07 31.1 2.7 0.22 11.9 0.0 4.8 2 2 1 4 4 4 3 HEAT repeats Pkinase_Tyr PF07714.17 CCF41397.1 - 7.1e-05 22.2 0.0 0.00011 21.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Cnd1 PF12717.7 CCF41397.1 - 0.001 19.2 0.1 6.4 6.8 0.0 3.8 2 2 2 4 4 4 1 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 CCF41397.1 - 0.0026 18.2 5.1 0.068 13.7 0.2 3.7 4 0 0 4 4 4 1 HEAT-like repeat Kinase-like PF14531.6 CCF41397.1 - 0.018 14.4 0.0 0.036 13.4 0.0 1.4 1 1 0 1 1 1 0 Kinase-like ANAPC4_WD40 PF12894.7 CCF41397.1 - 0.023 15.0 0.0 3 8.2 0.0 2.8 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Adaptin_N PF01602.20 CCF41397.1 - 0.039 12.5 0.2 1 7.8 0.0 2.2 2 0 0 2 2 2 0 Adaptin N terminal region RTP1_C1 PF10363.9 CCF41397.1 - 0.29 11.3 1.3 3.8 7.7 0.1 2.6 2 0 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 RasGEF_N_2 PF14663.6 CCF41397.1 - 0.36 11.2 1.2 2 8.8 0.1 2.4 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain LRR_9 PF14580.6 CCF41398.1 - 3.4e-55 186.2 0.1 5.8e-55 185.5 0.0 1.4 2 0 0 2 2 2 1 Leucine-rich repeat LRR_4 PF12799.7 CCF41398.1 - 2.6e-10 40.4 1.4 9.9e-06 25.8 0.2 3.3 3 1 1 4 4 4 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCF41398.1 - 1.2e-07 31.4 0.1 3.9e-07 29.7 0.1 2.0 1 0 0 1 1 1 1 Leucine rich repeat DUF4349 PF14257.6 CCF41398.1 - 0.0048 16.4 1.6 0.0093 15.4 1.6 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4349) T4_Gp59_C PF08994.10 CCF41398.1 - 0.098 13.3 0.0 0.24 12.0 0.0 1.6 2 0 0 2 2 2 0 T4 gene Gp59 loader of gp41 DNA helicase C-term PspB PF06667.12 CCF41398.1 - 0.16 12.0 1.4 0.52 10.4 1.4 1.8 1 0 0 1 1 1 0 Phage shock protein B ODV-E18 PF10717.9 CCF41401.1 - 3.4 7.6 6.1 24 4.9 0.1 2.8 2 1 1 3 3 3 0 Occlusion-derived virus envelope protein ODV-E18 Glyco_hydro_106 PF17132.4 CCF41402.1 - 4.5e-06 25.2 0.1 0.019 13.3 0.0 3.1 2 1 0 2 2 2 2 alpha-L-rhamnosidase Glyco_hydro_42M PF08532.10 CCF41402.1 - 0.071 12.6 0.0 0.16 11.4 0.0 1.5 1 0 0 1 1 1 0 Beta-galactosidase trimerisation domain NAD_binding_10 PF13460.6 CCF41403.1 - 1.3e-06 28.4 0.0 2.8e-06 27.3 0.0 1.5 1 1 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 CCF41403.1 - 3e-05 23.7 0.1 0.0071 15.9 0.0 2.2 2 0 0 2 2 2 2 NmrA-like family 2-Hacid_dh_C PF02826.19 CCF41403.1 - 0.0041 16.5 0.0 0.4 10.0 0.0 2.3 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Epimerase PF01370.21 CCF41403.1 - 0.017 14.6 0.0 0.16 11.4 0.0 2.0 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family RibD_C PF01872.17 CCF41404.1 - 1.8e-18 67.1 0.0 2.1e-17 63.6 0.0 1.9 1 1 0 1 1 1 1 RibD C-terminal domain DHFR_1 PF00186.19 CCF41404.1 - 5.4e-05 22.9 0.0 6.5e-05 22.7 0.0 1.1 1 0 0 1 1 1 1 Dihydrofolate reductase DUF3433 PF11915.8 CCF41405.1 - 4.1e-31 107.3 11.6 5.3e-18 65.3 2.1 3.0 2 0 0 2 2 2 2 Protein of unknown function (DUF3433) NmrA PF05368.13 CCF41406.1 - 2.6e-16 59.9 0.1 3.8e-16 59.3 0.1 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CCF41406.1 - 9.3e-09 35.4 0.4 1.5e-08 34.7 0.4 1.4 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CCF41406.1 - 0.00059 19.4 0.1 0.00094 18.7 0.1 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family HrpF PF06266.12 CCF41406.1 - 0.069 13.4 0.0 0.6 10.4 0.0 2.2 2 0 0 2 2 2 0 HrpF protein Beach PF02138.18 CCF41407.1 - 9e-119 395.9 0.0 1.4e-118 395.3 0.0 1.3 1 0 0 1 1 1 1 Beige/BEACH domain Laminin_G_3 PF13385.6 CCF41407.1 - 4.7e-11 43.0 0.0 1.1e-10 41.9 0.0 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily PH_BEACH PF14844.6 CCF41407.1 - 1.6e-10 41.0 0.0 4.2e-10 39.6 0.0 1.7 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH WD40 PF00400.32 CCF41407.1 - 0.0015 19.3 3.2 0.69 10.9 0.1 4.4 4 0 0 4 4 4 1 WD domain, G-beta repeat TFIIA PF03153.13 CCF41407.1 - 0.069 13.1 1.8 0.14 12.1 1.8 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DDOST_48kD PF03345.14 CCF41409.1 - 4.1e-149 496.9 0.0 3.3e-148 493.9 0.0 1.9 1 1 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta NAPRTase_C PF17956.1 CCF41409.1 - 0.13 12.7 0.0 0.28 11.6 0.0 1.6 1 0 0 1 1 1 0 Nicotinate phosphoribosyltransferase C-terminal domain Rogdi_lz PF10259.9 CCF41411.1 - 0.067 12.6 0.2 0.13 11.7 0.1 1.5 2 0 0 2 2 2 0 Rogdi leucine zipper containing protein HSDR_N_2 PF13588.6 CCF41411.1 - 0.1 12.6 0.1 0.33 11.0 0.0 1.8 2 0 0 2 2 2 0 Type I restriction enzyme R protein N terminus (HSDR_N) DUF3328 PF11807.8 CCF41412.1 - 2.8e-24 86.1 0.0 4.1e-24 85.6 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) DJ-1_PfpI PF01965.24 CCF41412.1 - 0.23 11.3 0.0 0.36 10.6 0.0 1.2 1 0 0 1 1 1 0 DJ-1/PfpI family Fungal_trans_2 PF11951.8 CCF41413.1 - 1e-32 113.4 0.9 2.1e-32 112.4 0.9 1.5 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF41413.1 - 5.8e-06 26.3 6.7 1.1e-05 25.5 6.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Chi-conotoxin PF16981.5 CCF41413.1 - 0.19 12.0 2.0 0.55 10.5 2.0 1.8 1 0 0 1 1 1 0 chi-Conotoxin or t superfamily FliMN_C PF01052.20 CCF41414.1 - 0.14 12.1 2.5 30 4.7 0.1 3.0 1 1 2 3 3 3 0 Type III flagellar switch regulator (C-ring) FliN C-term DUF4969 PF16339.5 CCF41414.1 - 0.22 11.9 2.2 0.34 11.3 0.7 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4969) DUF5040 PF16443.5 CCF41414.1 - 0.41 10.0 1.3 13 5.1 0.1 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF5040) Tyrosinase PF00264.20 CCF41415.1 - 1.1e-18 68.4 0.4 1.5e-18 68.0 0.4 1.2 1 0 0 1 1 1 1 Common central domain of tyrosinase DUF3328 PF11807.8 CCF41416.1 - 3.7e-06 26.9 0.0 5e-06 26.5 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) DUF3328 PF11807.8 CCF41418.1 - 7.6e-46 156.6 0.0 8.4e-46 156.5 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) ATP1G1_PLM_MAT8 PF02038.16 CCF41419.1 - 0.0039 16.6 1.2 0.0074 15.7 1.2 1.3 1 0 0 1 1 1 1 ATP1G1/PLM/MAT8 family Jun PF03957.13 CCF41419.1 - 0.037 13.9 0.1 0.052 13.4 0.1 1.3 1 0 0 1 1 1 0 Jun-like transcription factor DUF3224 PF11528.8 CCF41420.1 - 0.14 11.9 1.3 0.27 11.1 0.5 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3224) Sec61_beta PF03911.16 CCF41421.1 - 2.9e-19 68.8 1.9 4.2e-19 68.3 1.9 1.3 1 0 0 1 1 1 1 Sec61beta family Glyco_transf_25 PF01755.17 CCF41422.1 - 1.1e-12 48.2 0.0 4.9e-10 39.6 0.0 2.2 2 0 0 2 2 2 2 Glycosyltransferase family 25 (LPS biosynthesis protein) DUF1799 PF08809.11 CCF41422.1 - 0.047 13.9 0.3 0.11 12.7 0.3 1.5 1 0 0 1 1 1 0 Phage related hypothetical protein (DUF1799) Tup_N PF08581.10 CCF41423.1 - 3.8e-05 23.9 32.8 0.13 12.6 1.3 6.1 2 1 4 6 6 6 4 Tup N-terminal Spc7 PF08317.11 CCF41423.1 - 0.00017 20.6 60.5 0.011 14.6 20.3 3.1 1 1 2 3 3 3 3 Spc7 kinetochore protein Rab5-bind PF09311.11 CCF41423.1 - 0.00058 19.3 44.1 0.0037 16.7 10.8 3.9 1 1 3 4 4 4 3 Rabaptin-like protein CCDC-167 PF15188.6 CCF41423.1 - 0.017 15.4 2.8 0.017 15.4 2.8 5.1 1 1 2 3 3 3 0 Coiled-coil domain-containing protein 167 Spectrin PF00435.21 CCF41423.1 - 0.033 14.7 9.2 0.033 14.7 9.2 4.2 1 1 2 4 4 4 0 Spectrin repeat TPR_MLP1_2 PF07926.12 CCF41423.1 - 0.29 11.2 78.7 0.034 14.2 7.2 4.4 1 1 2 4 4 4 0 TPR/MLP1/MLP2-like protein rve_3 PF13683.6 CCF41423.1 - 0.54 10.1 11.1 6.1 6.7 0.2 4.7 2 1 3 5 5 5 0 Integrase core domain Lebercilin PF15619.6 CCF41423.1 - 0.7 9.5 58.0 0.76 9.4 9.6 4.6 1 1 4 5 5 5 0 Ciliary protein causing Leber congenital amaurosis disease DASH_Dam1 PF08653.10 CCF41423.1 - 2.2 8.2 8.0 25 4.8 0.1 4.4 4 1 2 6 6 6 0 DASH complex subunit Dam1 Filament PF00038.21 CCF41423.1 - 5 6.6 49.4 0.38 10.3 18.0 3.1 1 1 2 3 3 3 0 Intermediate filament protein Tmemb_cc2 PF10267.9 CCF41423.1 - 9.8 5.2 45.7 0.81 8.8 25.1 3.0 1 1 2 3 3 3 0 Predicted transmembrane and coiled-coil 2 protein DUF2418 PF10332.9 CCF41424.1 - 7e-38 129.1 0.5 7.1e-37 125.8 0.4 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF2418) Response_reg PF00072.24 CCF41426.1 - 3.2e-07 30.5 0.0 4.7e-06 26.7 0.0 2.1 1 1 0 1 1 1 1 Response regulator receiver domain Pyr_redox_2 PF07992.14 CCF41428.1 - 7.4e-51 173.1 3.4 1.3e-50 172.4 3.4 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Rieske PF00355.26 CCF41428.1 - 1.9e-15 56.5 0.0 4.5e-15 55.4 0.0 1.6 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Pyr_redox PF00070.27 CCF41428.1 - 2e-13 50.7 0.8 2e-13 50.7 0.8 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Reductase_C PF14759.6 CCF41428.1 - 5.3e-06 26.9 0.0 1.5e-05 25.5 0.0 1.8 1 0 0 1 1 1 1 Reductase C-terminal Rieske_2 PF13806.6 CCF41428.1 - 0.00012 22.0 0.0 0.00044 20.1 0.0 2.0 2 0 0 2 2 2 1 Rieske-like [2Fe-2S] domain K_oxygenase PF13434.6 CCF41428.1 - 0.00037 19.7 0.0 0.94 8.5 0.0 2.5 2 1 1 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 CCF41428.1 - 0.0093 16.0 3.6 0.72 9.8 0.0 3.0 3 0 0 3 3 3 2 FAD-NAD(P)-binding DUF1188 PF06690.11 CCF41428.1 - 0.016 14.8 0.1 0.023 14.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1188) FAD_binding_3 PF01494.19 CCF41429.1 - 3.4e-13 49.6 0.0 3.6e-13 49.5 0.0 1.0 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 CCF41429.1 - 3.1e-05 23.7 0.1 3.3e-05 23.7 0.1 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 CCF41429.1 - 0.0017 18.9 0.0 0.002 18.6 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CCF41429.1 - 0.0031 16.8 0.0 0.0033 16.7 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCF41429.1 - 0.0038 17.4 0.0 0.0041 17.3 0.0 1.2 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 CCF41429.1 - 0.043 12.9 0.0 0.045 12.8 0.0 1.0 1 0 0 1 1 1 0 FAD binding domain GIDA PF01134.22 CCF41429.1 - 0.077 12.1 0.0 0.078 12.0 0.0 1.0 1 0 0 1 1 1 0 Glucose inhibited division protein A Thi4 PF01946.17 CCF41429.1 - 0.17 11.1 0.0 0.19 11.0 0.0 1.0 1 0 0 1 1 1 0 Thi4 family Cutinase PF01083.22 CCF41430.1 - 3.3e-26 92.3 1.4 5e-26 91.7 1.4 1.3 1 0 0 1 1 1 1 Cutinase FAD_binding_2 PF00890.24 CCF41434.1 - 6.3e-70 236.4 0.2 9.3e-70 235.8 0.2 1.1 1 0 0 1 1 1 1 FAD binding domain FAD_binding_3 PF01494.19 CCF41434.1 - 1.4e-06 27.8 0.1 5.1e-06 26.0 0.0 1.8 2 0 0 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.6 CCF41434.1 - 3.3e-06 27.2 0.1 9.6e-06 25.7 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CCF41434.1 - 5e-05 23.0 2.3 0.0002 21.0 2.3 1.9 1 1 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.22 CCF41434.1 - 5.9e-05 22.3 0.1 8.8e-05 21.7 0.1 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A FAD_oxidored PF12831.7 CCF41434.1 - 0.00018 21.0 0.0 0.00031 20.2 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCF41434.1 - 0.0014 17.9 0.1 0.0056 16.0 0.1 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CCF41434.1 - 0.0037 16.0 0.1 0.0075 15.0 0.1 1.5 1 0 0 1 1 1 1 HI0933-like protein Thi4 PF01946.17 CCF41434.1 - 0.0047 16.2 0.1 0.01 15.1 0.1 1.5 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.6 CCF41434.1 - 0.034 13.4 0.2 0.095 11.9 0.1 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCF41434.1 - 0.056 14.0 0.1 5.2 7.7 0.1 3.1 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase EAR PF07897.11 CCF41434.1 - 0.075 12.7 0.0 0.19 11.3 0.0 1.7 1 0 0 1 1 1 0 Ethylene-responsive binding factor-associated repression Fungal_trans PF04082.18 CCF41436.1 - 1.9e-17 63.2 0.7 3.2e-17 62.5 0.7 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF41436.1 - 3.7e-06 27.0 6.1 7.2e-06 26.0 6.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Dickkopf_N PF04706.12 CCF41436.1 - 8.2 7.0 11.4 2.1 8.9 3.2 2.3 1 1 1 2 2 2 0 Dickkopf N-terminal cysteine-rich region Dala_Dala_lig_C PF07478.13 CCF41437.1 - 1.6e-09 37.6 0.0 2.4e-09 37.1 0.0 1.2 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.14 CCF41437.1 - 0.002 18.2 0.0 0.003 17.6 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain CPSase_L_D2 PF02786.17 CCF41437.1 - 0.0036 16.8 0.0 0.0044 16.5 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp_4 PF13535.6 CCF41437.1 - 0.0037 16.9 0.0 0.017 14.8 0.0 1.9 1 1 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.19 CCF41437.1 - 0.04 13.7 0.0 0.057 13.2 0.0 1.2 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ImcF-related_N PF14331.6 CCF41437.1 - 0.043 13.2 0.0 0.074 12.4 0.0 1.3 1 0 0 1 1 1 0 ImcF-related N-terminal domain RimK PF08443.11 CCF41437.1 - 0.1 12.2 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 RimK-like ATP-grasp domain Ins134_P3_kin PF05770.11 CCF41437.1 - 0.16 11.5 0.0 0.3 10.6 0.0 1.5 1 0 0 1 1 1 0 Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain DUF3387 PF11867.8 CCF41438.1 - 0.17 11.3 0.2 6.3 6.1 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3387) Ribosomal_L18A PF01775.17 CCF41439.1 - 2.7e-54 182.4 0.3 3.5e-54 182.1 0.3 1.1 1 0 0 1 1 1 1 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A Phytase PF02333.15 CCF41441.1 - 5.7e-46 157.2 0.1 6.1e-46 157.1 0.1 1.0 1 0 0 1 1 1 1 Phytase MIase PF02426.16 CCF41442.1 - 0.12 12.6 0.2 0.19 11.9 0.2 1.4 1 0 0 1 1 1 0 Muconolactone delta-isomerase DUF4220 PF13968.6 CCF41443.1 - 0.0014 18.1 0.0 0.0026 17.2 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4220) Sugar_tr PF00083.24 CCF41445.1 - 3.5e-85 286.6 23.2 4.2e-85 286.3 23.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF41445.1 - 1e-19 70.7 34.3 1.7e-14 53.5 11.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily PUCC PF03209.15 CCF41445.1 - 0.0046 16.0 9.2 0.01 14.9 0.3 2.5 2 1 0 2 2 2 2 PUCC protein MOSC PF03473.17 CCF41446.1 - 1.1e-23 83.7 0.0 1.7e-23 83.1 0.0 1.3 1 0 0 1 1 1 1 MOSC domain MOSC_N PF03476.16 CCF41446.1 - 7.6e-11 41.9 0.0 1.8e-10 40.7 0.0 1.7 1 1 0 1 1 1 1 MOSC N-terminal beta barrel domain CsoSCA PF08936.10 CCF41447.1 - 0.15 10.7 0.2 0.22 10.2 0.2 1.1 1 0 0 1 1 1 0 Carboxysome Shell Carbonic Anhydrase Rad10 PF03834.14 CCF41448.1 - 5.8e-47 158.4 0.0 7.9e-47 158.0 0.0 1.2 1 0 0 1 1 1 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) AA_permease PF00324.21 CCF41450.1 - 1.4e-33 116.2 6.6 1.7e-33 116.0 6.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CCF41450.1 - 1.6e-10 40.4 5.1 2e-10 40.1 5.1 1.1 1 0 0 1 1 1 1 Amino acid permease DUF4064 PF13273.6 CCF41450.1 - 0.92 9.8 5.7 5.6 7.3 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) T_cell_tran_alt PF15128.6 CCF41450.1 - 0.97 9.3 4.3 0.17 11.7 0.5 1.7 2 0 0 2 2 2 0 T-cell leukemia translocation-altered Caldesmon PF02029.15 CCF41451.1 - 0.0074 15.1 0.4 0.012 14.4 0.4 1.2 1 0 0 1 1 1 1 Caldesmon bZIP_2 PF07716.15 CCF41452.1 - 0.0055 16.7 8.9 0.035 14.2 8.9 2.1 1 1 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 CCF41452.1 - 0.013 15.6 4.6 0.027 14.6 4.6 1.7 1 0 0 1 1 1 0 bZIP transcription factor DUF3435 PF11917.8 CCF41454.1 - 9.8e-107 357.5 0.1 3.4e-106 355.7 0.1 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF3435) zf-C2H2 PF00096.26 CCF41454.1 - 3 8.5 7.5 3.5 8.2 1.4 2.8 2 0 0 2 2 2 0 Zinc finger, C2H2 type PRP38 PF03371.15 CCF41456.1 - 6.6e-55 185.6 0.0 8.2e-55 185.3 0.0 1.1 1 0 0 1 1 1 1 PRP38 family DUF1509 PF07420.11 CCF41456.1 - 0.58 9.1 11.1 0.83 8.5 11.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1509) Corona_nucleoca PF00937.18 CCF41456.1 - 1.7 7.6 5.8 2.2 7.2 5.8 1.2 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein CDC45 PF02724.14 CCF41456.1 - 2.6 6.2 8.7 3.1 6.0 8.7 1.1 1 0 0 1 1 1 0 CDC45-like protein Amidase PF01425.21 CCF41457.1 - 4.2e-36 124.9 0.0 5.6e-36 124.5 0.0 1.2 1 0 0 1 1 1 1 Amidase Ank_4 PF13637.6 CCF41458.1 - 3.6e-13 49.7 1.8 1.8e-06 28.4 0.0 4.4 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 CCF41458.1 - 7.6e-10 39.2 0.0 0.0082 16.7 0.0 3.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CCF41458.1 - 2.4e-09 36.7 0.3 0.00042 20.5 0.0 4.7 5 0 0 5 5 5 2 Ankyrin repeat Ank PF00023.30 CCF41458.1 - 8.8e-09 35.4 1.5 0.0013 19.1 0.1 4.1 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 CCF41458.1 - 9.7e-07 29.0 0.1 0.054 13.8 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeats (many copies) KilA-N PF04383.13 CCF41458.1 - 3.8e-05 23.5 1.1 0.00027 20.8 0.3 2.5 2 1 0 2 2 2 1 KilA-N domain Peptidase_S10 PF00450.22 CCF41459.1 - 1e-15 58.1 0.0 1.2e-15 57.9 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase BTB PF00651.31 CCF41460.1 - 2.8e-07 30.8 0.0 7.7e-07 29.3 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain Abhydrolase_6 PF12697.7 CCF41463.1 - 1.2e-05 26.1 2.4 1.8e-05 25.5 2.4 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCF41463.1 - 8.7e-05 21.9 0.0 0.0002 20.7 0.1 1.5 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CCF41463.1 - 0.015 15.0 0.1 0.041 13.5 0.2 1.7 2 1 0 2 2 2 0 alpha/beta hydrolase fold ADH_zinc_N PF00107.26 CCF41464.1 - 3.4e-16 59.4 0.1 4.4e-16 59.0 0.1 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCF41464.1 - 7.6e-10 40.0 0.0 1.5e-09 39.0 0.0 1.5 1 1 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 CCF41464.1 - 0.024 13.9 0.1 0.035 13.4 0.1 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Epimerase PF01370.21 CCF41464.1 - 0.1 12.0 0.2 0.13 11.7 0.2 1.1 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family MOSC PF03473.17 CCF41465.1 - 4.3e-22 78.5 0.0 7.7e-22 77.7 0.0 1.4 1 0 0 1 1 1 1 MOSC domain MOSC_N PF03476.16 CCF41465.1 - 6.5e-12 45.4 0.0 3.3e-11 43.1 0.0 2.1 3 0 0 3 3 3 1 MOSC N-terminal beta barrel domain SMC_N PF02463.19 CCF41466.1 - 1.1e-70 237.5 1.4 1.1e-69 234.3 1.4 2.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 CCF41466.1 - 3.5e-20 72.4 5.2 3.9e-20 72.3 0.3 3.1 3 0 0 3 3 3 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.6 CCF41466.1 - 2.5e-10 41.2 18.3 2.5e-10 41.2 18.3 6.9 2 2 1 3 3 3 1 AAA domain AAA_21 PF13304.6 CCF41466.1 - 1.8e-08 34.6 13.1 0.00016 21.6 0.1 4.2 4 2 1 5 5 5 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CCF41466.1 - 0.00013 21.7 0.1 0.0003 20.5 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain Myosin_tail_1 PF01576.19 CCF41466.1 - 0.00037 18.5 47.5 0.00037 18.5 47.5 2.1 2 0 0 2 2 2 1 Myosin tail GAS PF13851.6 CCF41466.1 - 0.0024 17.2 9.1 0.0024 17.2 9.1 7.5 3 2 4 7 7 7 2 Growth-arrest specific micro-tubule binding ABC_tran PF00005.27 CCF41466.1 - 0.15 12.5 0.0 0.15 12.5 0.0 6.0 4 2 0 4 4 4 0 ABC transporter FDX-ACB PF03147.14 CCF41466.1 - 8.2 6.9 10.5 2.8 8.4 1.5 4.2 4 0 0 4 4 4 0 Ferredoxin-fold anticodon binding domain NT5C PF06941.12 CCF41467.1 - 0.037 13.9 0.0 0.056 13.3 0.0 1.2 1 0 0 1 1 1 0 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) PGM_PMM_III PF02880.16 CCF41469.1 - 2.9e-26 91.9 0.0 5.2e-26 91.1 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 CCF41469.1 - 4.6e-13 49.7 0.0 1.2e-12 48.3 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 CCF41469.1 - 2.5e-06 27.6 0.0 4.7e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Aa_trans PF01490.18 CCF41470.1 - 4.1e-81 272.8 17.3 4.9e-81 272.5 17.3 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein BUD22 PF09073.10 CCF41470.1 - 0.17 11.2 3.3 0.25 10.6 3.3 1.2 1 0 0 1 1 1 0 BUD22 PBP1_TM PF14812.6 CCF41470.1 - 2.1 8.8 12.5 3.5 8.1 6.5 2.4 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal SPX PF03105.19 CCF41470.1 - 3.2 7.6 6.5 4.8 7.0 6.5 1.2 1 0 0 1 1 1 0 SPX domain NOA36 PF06524.12 CCF41470.1 - 6.3 6.0 10.9 0.72 9.1 2.1 2.1 2 0 0 2 2 2 0 NOA36 protein Velvet PF11754.8 CCF41474.1 - 9.4e-39 133.9 0.5 4.7e-31 108.6 0.2 3.1 2 1 1 3 3 3 2 Velvet factor EPL1 PF10513.9 CCF41474.1 - 0.065 13.6 4.9 0.09 13.2 4.9 1.3 1 0 0 1 1 1 0 Enhancer of polycomb-like Spt20 PF12090.8 CCF41474.1 - 0.12 12.0 29.0 0.17 11.5 29.0 1.3 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.13 CCF41474.1 - 0.94 9.4 30.3 1.4 8.9 30.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SpoIIP PF07454.11 CCF41474.1 - 1.3 8.4 7.1 1.4 8.3 6.4 1.4 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) Glyco_hydro_11 PF00457.17 CCF41475.1 - 1.5e-43 148.4 14.2 1.8e-43 148.2 14.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 11 Ribosomal_S7 PF00177.21 CCF41477.1 - 2.3e-24 85.7 0.0 4.4e-24 84.8 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e EOS1 PF12326.8 CCF41478.1 - 8.9e-16 58.3 4.8 1.7e-15 57.4 1.3 2.1 1 1 1 2 2 2 1 N-glycosylation protein FA_desaturase PF00487.24 CCF41478.1 - 0.04 13.8 2.5 0.079 12.8 0.1 2.1 2 0 0 2 2 2 0 Fatty acid desaturase SLATT_5 PF18160.1 CCF41478.1 - 0.13 11.6 0.7 0.25 10.6 0.7 1.4 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 SUI1 PF01253.22 CCF41479.1 - 6.1e-27 94.0 4.2 8.5e-27 93.5 4.2 1.2 1 0 0 1 1 1 1 Translation initiation factor SUI1 Ank_4 PF13637.6 CCF41480.1 - 1.6e-31 108.2 0.9 2.6e-09 37.4 0.1 9.2 5 2 4 9 9 9 6 Ankyrin repeats (many copies) Ank_2 PF12796.7 CCF41480.1 - 2.1e-29 101.9 0.0 8e-12 45.6 0.0 6.4 4 3 2 6 6 6 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CCF41480.1 - 5.7e-28 93.9 8.4 0.017 15.6 0.0 10.6 12 0 0 12 12 12 9 Ankyrin repeat Ank_5 PF13857.6 CCF41480.1 - 1.7e-23 82.4 7.1 8.5e-10 38.7 0.2 7.6 5 2 3 8 8 8 7 Ankyrin repeats (many copies) Ank PF00023.30 CCF41480.1 - 2.1e-23 81.7 4.8 0.0063 16.9 0.0 8.4 10 0 0 10 10 10 5 Ankyrin repeat Zf_RING PF16744.5 CCF41481.1 - 0.055 13.6 0.9 0.15 12.2 0.9 1.7 1 0 0 1 1 1 0 KIAA1045 RING finger TPR_2 PF07719.17 CCF41481.1 - 0.076 13.2 0.4 0.076 13.2 0.4 2.5 3 0 0 3 3 3 0 Tetratricopeptide repeat BLACT_WH PF17778.1 CCF41481.1 - 0.13 12.3 0.0 0.32 11.0 0.0 1.8 1 0 0 1 1 1 0 Beta-lactamase associated winged helix domain TPR_11 PF13414.6 CCF41481.1 - 0.54 10.0 4.4 2.4 7.9 0.4 3.0 3 0 0 3 3 3 0 TPR repeat Auxin_repressed PF05564.12 CCF41482.1 - 0.59 10.8 3.9 18 6.0 0.8 2.5 2 0 0 2 2 2 0 Dormancy/auxin associated protein KTI12 PF08433.10 CCF41483.1 - 1.9e-63 214.5 0.0 3.8e-63 213.5 0.0 1.5 1 1 0 1 1 1 1 Chromatin associated protein KTI12 Mucin PF01456.17 CCF41483.1 - 0.035 14.1 12.6 0.33 11.0 4.4 2.2 2 0 0 2 2 2 0 Mucin-like glycoprotein AAA_18 PF13238.6 CCF41483.1 - 0.11 13.1 0.0 0.35 11.4 0.0 2.0 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.6 CCF41483.1 - 0.11 12.6 4.4 0.41 10.8 4.4 2.0 1 1 0 1 1 1 0 AAA domain Nop53 PF07767.11 CCF41483.1 - 0.11 11.8 1.6 0.23 10.8 1.6 1.4 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) DUF3246 PF11596.8 CCF41483.1 - 1.3 8.4 12.3 0.11 11.9 5.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3246) NOA36 PF06524.12 CCF41483.1 - 2.1 7.6 4.4 3.7 6.8 4.4 1.3 1 0 0 1 1 1 0 NOA36 protein Lactamase_B PF00753.27 CCF41486.1 - 3.2e-14 53.4 0.2 4.2e-14 53.0 0.2 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CCF41486.1 - 1.2e-05 24.9 0.0 1.5e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain MDH PF02315.16 CCF41486.1 - 0.17 12.0 0.0 0.31 11.1 0.0 1.4 1 0 0 1 1 1 0 Methanol dehydrogenase beta subunit Lipase_GDSL_2 PF13472.6 CCF41487.1 - 1.5e-11 45.0 0.4 1.9e-11 44.7 0.4 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 CCF41487.1 - 0.0024 17.8 0.0 0.003 17.6 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Tad PF13400.6 CCF41488.1 - 1.9 8.8 0.0 1.9 8.8 0.0 3.2 4 0 0 4 4 4 0 Putative Flp pilus-assembly TadE/G-like Abhydrolase_1 PF00561.20 CCF41490.1 - 1.1e-22 80.9 0.2 2.2e-21 76.6 0.2 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CCF41490.1 - 9.1e-21 74.2 0.1 1.1e-12 47.7 0.1 2.0 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CCF41490.1 - 7.9e-20 72.4 0.1 1e-19 72.0 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 CCF41490.1 - 8.2e-07 28.7 0.0 0.037 13.5 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family Ndr PF03096.14 CCF41490.1 - 7.1e-06 24.9 0.0 8.7e-06 24.6 0.0 1.1 1 0 0 1 1 1 1 Ndr family Abhydrolase_3 PF07859.13 CCF41490.1 - 0.00048 20.1 0.0 0.0012 18.7 0.0 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.7 CCF41490.1 - 0.00074 19.3 0.0 0.93 9.2 0.0 2.2 2 0 0 2 2 2 2 Alpha/beta hydrolase family Abhydrolase_4 PF08386.10 CCF41490.1 - 0.00079 19.5 0.0 0.0014 18.7 0.0 1.4 1 0 0 1 1 1 1 TAP-like protein FSH1 PF03959.13 CCF41490.1 - 0.0025 17.5 0.0 0.0041 16.8 0.0 1.3 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Thioesterase PF00975.20 CCF41490.1 - 0.042 14.0 0.0 0.068 13.3 0.0 1.3 1 0 0 1 1 1 0 Thioesterase domain Ser_hydrolase PF06821.13 CCF41490.1 - 0.044 13.6 0.0 2.2 8.1 0.0 2.1 2 0 0 2 2 2 0 Serine hydrolase AXE1 PF05448.12 CCF41490.1 - 0.06 12.0 0.2 4.1 6.0 0.0 2.8 2 1 1 3 3 3 0 Acetyl xylan esterase (AXE1) UPF0227 PF05728.12 CCF41490.1 - 0.16 11.9 0.0 0.34 10.8 0.0 1.6 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0227) Fungal_trans PF04082.18 CCF41491.1 - 5.4e-16 58.4 0.1 8.1e-16 57.8 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Ribonuclease_T2 PF00445.18 CCF41495.1 - 4.5e-35 121.5 0.6 6.2e-35 121.1 0.6 1.1 1 0 0 1 1 1 1 Ribonuclease T2 family BTB PF00651.31 CCF41496.1 - 0.00097 19.3 0.0 0.0013 18.9 0.0 1.2 1 0 0 1 1 1 1 BTB/POZ domain PH PF00169.29 CCF41497.1 - 0.00027 21.4 0.0 0.001 19.5 0.1 2.0 2 0 0 2 2 2 1 PH domain DUF5344 PF17279.2 CCF41497.1 - 0.063 13.9 0.2 0.96 10.1 0.0 2.8 3 0 0 3 3 3 0 Family of unknown function (DUF5344) WEMBL PF05701.11 CCF41497.1 - 0.12 11.0 2.0 0.18 10.4 2.0 1.2 1 0 0 1 1 1 0 Weak chloroplast movement under blue light Ribosomal_L15e PF00827.17 CCF41498.1 - 2.1e-89 298.4 9.8 2.5e-89 298.1 9.8 1.0 1 0 0 1 1 1 1 Ribosomal L15 N_NLPC_P60 PF12912.7 CCF41499.1 - 0.0065 16.8 0.1 0.041 14.3 0.1 2.0 2 0 0 2 2 2 1 NLPC_P60 stabilising domain, N term MoeA_N PF03453.17 CCF41499.1 - 0.062 13.1 0.0 0.091 12.5 0.0 1.2 1 0 0 1 1 1 0 MoeA N-terminal region (domain I and II) RED_N PF07808.13 CCF41500.1 - 2.6e-07 30.5 10.0 2.6e-07 30.5 10.0 3.0 2 1 0 2 2 2 1 RED-like protein N-terminal region DUF2924 PF11149.8 CCF41500.1 - 0.022 15.1 0.5 0.022 15.1 0.5 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2924) IU_nuc_hydro PF01156.19 CCF41501.1 - 5e-85 285.7 0.1 6e-85 285.5 0.1 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase Mito_carr PF00153.27 CCF41502.1 - 4.9e-64 212.3 0.7 4.8e-21 74.5 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Sod_Fe_C PF02777.18 CCF41504.1 - 1.8e-14 53.7 0.0 5.2e-12 45.8 0.0 2.4 1 1 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 CCF41504.1 - 0.0046 17.4 0.1 0.0071 16.8 0.1 1.3 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain F-box-like PF12937.7 CCF41505.1 - 0.00093 19.0 0.0 0.014 15.3 0.0 2.9 3 1 0 3 3 3 1 F-box-like NUP50 PF08911.11 CCF41506.1 - 0.68 10.6 9.0 0.13 12.9 4.6 2.2 2 1 0 2 2 2 0 NUP50 (Nucleoporin 50 kDa) MFS_1 PF07690.16 CCF41508.1 - 2.8e-28 98.9 10.9 3.1e-28 98.7 10.9 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 CCF41508.1 - 0.00052 19.4 3.0 0.00079 18.8 3.0 1.2 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB ApbA PF02558.16 CCF41509.1 - 5.2e-32 110.6 0.0 7e-32 110.2 0.0 1.2 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ApbA_C PF08546.11 CCF41509.1 - 7.3e-30 103.7 0.0 1.1e-29 103.2 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ThiF PF00899.21 CCF41509.1 - 0.15 11.4 0.0 0.31 10.4 0.0 1.4 1 0 0 1 1 1 0 ThiF family Amidohydro_3 PF07969.11 CCF41510.1 - 2.4e-12 47.1 1.1 3.1e-09 36.8 0.1 2.4 2 0 0 2 2 2 2 Amidohydrolase family Amidohydro_1 PF01979.20 CCF41510.1 - 4e-09 36.3 1.9 2.8e-08 33.5 0.0 2.6 3 1 0 3 3 3 1 Amidohydrolase family Med26 PF08711.11 CCF41511.1 - 3.7e-11 42.9 0.0 1e-10 41.5 0.0 1.8 1 0 0 1 1 1 1 TFIIS helical bundle-like domain DUF4145 PF13643.6 CCF41511.1 - 0.073 13.2 0.3 0.13 12.4 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4145) Brr6_like_C_C PF10104.9 CCF41512.1 - 3.6e-34 117.4 5.1 4.4e-34 117.1 5.1 1.1 1 0 0 1 1 1 1 Di-sulfide bridge nucleocytoplasmic transport domain PBP1_TM PF14812.6 CCF41512.1 - 0.13 12.6 6.2 1.3 9.4 6.2 2.1 1 1 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal BPL_N PF09825.9 CCF41513.1 - 0.055 12.5 1.2 0.061 12.4 1.2 1.1 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal HBB PF06777.11 CCF41513.1 - 0.069 12.8 1.7 0.079 12.6 1.7 1.1 1 0 0 1 1 1 0 Helical and beta-bridge domain FlaC_arch PF05377.11 CCF41513.1 - 0.94 9.9 4.5 5.3 7.5 0.4 2.2 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) IFP_35_N PF07334.13 CCF41513.1 - 7.3 6.7 8.7 5.1 7.3 0.6 2.2 1 1 1 2 2 2 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus HMG_box_2 PF09011.10 CCF41514.1 - 2.1e-12 47.4 8.1 3.2e-09 37.3 0.4 3.2 3 0 0 3 3 3 2 HMG-box domain HMG_box PF00505.19 CCF41514.1 - 1.3e-05 25.5 3.6 1.3e-05 25.5 3.6 3.5 2 2 0 2 2 2 1 HMG (high mobility group) box 3Beta_HSD PF01073.19 CCF41516.1 - 1.2e-67 227.8 0.0 1.5e-67 227.6 0.0 1.0 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 CCF41516.1 - 1.9e-32 112.7 1.0 2.5e-32 112.2 0.4 1.4 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CCF41516.1 - 2.4e-17 63.3 0.0 7.9e-15 55.1 0.1 2.3 2 1 0 2 2 2 2 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 CCF41516.1 - 7.1e-16 58.1 0.4 1.3e-15 57.3 0.4 1.4 1 1 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 CCF41516.1 - 6.2e-12 45.2 0.6 3.7e-09 36.1 0.1 2.1 1 1 0 2 2 2 2 Male sterility protein NAD_binding_10 PF13460.6 CCF41516.1 - 1.5e-11 44.5 0.4 2.2e-11 44.0 0.4 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 CCF41516.1 - 5.6e-07 29.0 1.9 1.7e-06 27.4 1.9 1.8 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein KR PF08659.10 CCF41516.1 - 0.0024 17.8 5.2 0.026 14.4 5.2 2.2 1 1 0 1 1 1 1 KR domain DapB_N PF01113.20 CCF41516.1 - 0.012 15.7 0.5 0.021 15.0 0.5 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus NAD_binding_3 PF03447.16 CCF41516.1 - 0.015 16.0 0.3 0.027 15.1 0.3 1.5 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain FtsJ PF01728.19 CCF41516.1 - 0.14 12.2 0.2 0.24 11.5 0.2 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase RhoGAP PF00620.27 CCF41517.1 - 2.9e-36 124.6 0.0 6.1e-36 123.5 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain LIM PF00412.22 CCF41517.1 - 3.1e-30 104.2 41.7 1.8e-11 44.1 5.1 5.0 5 0 0 5 5 5 4 LIM domain Spt20 PF12090.8 CCF41517.1 - 0.02 14.5 14.6 0.044 13.4 14.6 1.5 1 0 0 1 1 1 0 Spt20 family Desulfoferrod_N PF06397.12 CCF41517.1 - 0.12 12.0 0.1 0.6 9.8 0.1 2.3 1 0 0 1 1 1 0 Desulfoferrodoxin, N-terminal domain zf_C2H2_13 PF18508.1 CCF41517.1 - 0.46 10.1 2.8 0.29 10.8 0.1 2.2 2 0 0 2 2 2 0 Zinc finger domain TFIIA PF03153.13 CCF41517.1 - 0.97 9.4 13.7 3.2 7.7 13.7 1.8 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit EutQ PF06249.12 CCF41518.1 - 3.5e-10 39.9 0.0 5.9e-10 39.1 0.0 1.2 1 0 0 1 1 1 1 Ethanolamine utilisation protein EutQ Cupin_3 PF05899.12 CCF41518.1 - 7.1e-09 35.2 0.0 1.2e-08 34.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF861) Cupin_2 PF07883.11 CCF41518.1 - 2.5e-05 23.9 0.0 3.8e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Cupin domain Pirin PF02678.16 CCF41518.1 - 0.061 13.3 0.0 0.093 12.7 0.0 1.3 1 0 0 1 1 1 0 Pirin Cupin_1 PF00190.22 CCF41518.1 - 0.068 12.8 0.0 0.093 12.3 0.0 1.3 1 0 0 1 1 1 0 Cupin Cupin_6 PF12852.7 CCF41518.1 - 0.12 12.1 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 Cupin Hamartin PF04388.12 CCF41518.1 - 9.6 4.7 9.9 11 4.6 9.9 1.0 1 0 0 1 1 1 0 Hamartin protein DUF3445 PF11927.8 CCF41519.1 - 1.7e-77 260.1 0.0 2.1e-77 259.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3445) EpCAM_N PF18635.1 CCF41520.1 - 0.1 12.8 7.7 0.27 11.4 4.6 2.5 2 0 0 2 2 2 0 Epithelial cell adhesion molecule N-terminal domain Glyco_hydro_71 PF03659.14 CCF41521.1 - 1.6e-127 425.4 8.6 1.6e-127 425.4 8.6 2.0 2 0 0 2 2 2 1 Glycosyl hydrolase family 71 Pkinase PF00069.25 CCF41522.1 - 1.7e-41 142.3 0.0 2.5e-41 141.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF41522.1 - 5.6e-22 78.3 0.0 7.8e-22 77.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF41522.1 - 0.00077 18.9 0.0 0.0013 18.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 CCF41522.1 - 0.0027 17.1 0.0 0.0047 16.3 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 CCF41522.1 - 0.013 14.3 0.0 0.022 13.5 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 CCF41522.1 - 0.046 13.6 0.3 0.046 13.6 0.3 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 CCF41522.1 - 0.22 10.5 0.0 0.41 9.6 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Chitin_bind_1 PF00187.19 CCF41523.1 - 5e-20 71.7 88.9 5.6e-09 36.3 19.1 4.4 3 1 0 4 4 4 3 Chitin recognition protein Peroxidase_2 PF01328.17 CCF41524.1 - 4e-41 141.6 0.0 5.1e-41 141.3 0.0 1.1 1 0 0 1 1 1 1 Peroxidase, family 2 YjeF_N PF03853.15 CCF41525.1 - 4.3e-32 111.4 0.0 5.2e-32 111.1 0.0 1.1 1 0 0 1 1 1 1 YjeF-related protein N-terminus NAD_binding_10 PF13460.6 CCF41525.1 - 0.22 11.4 0.0 0.29 11.0 0.0 1.2 1 0 0 1 1 1 0 NAD(P)H-binding MIP PF00230.20 CCF41526.1 - 5.1e-43 147.4 9.1 6.2e-43 147.1 9.1 1.1 1 0 0 1 1 1 1 Major intrinsic protein RSN1_7TM PF02714.15 CCF41527.1 - 1.1e-78 264.3 22.3 1.4e-78 264.0 22.3 1.1 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 CCF41527.1 - 1.2e-17 64.7 0.0 1.7e-17 64.2 0.0 1.2 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter Vps53_N PF04100.12 CCF41529.1 - 1.8e-31 109.5 2.1 2e-31 109.3 2.1 1.0 1 0 0 1 1 1 1 Vps53-like, N-terminal Flagellin_N PF00669.20 CCF41529.1 - 0.00023 21.3 5.2 0.0018 18.4 0.3 2.1 1 1 1 2 2 2 1 Bacterial flagellin N-terminal helical region DUF5082 PF16888.5 CCF41529.1 - 0.0009 19.5 2.4 0.044 14.1 0.4 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF5082) Spc7 PF08317.11 CCF41529.1 - 0.0016 17.4 1.8 0.0019 17.1 1.8 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein DUF812 PF05667.11 CCF41529.1 - 0.0027 16.7 0.4 0.003 16.5 0.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF812) Vps54_N PF10475.9 CCF41529.1 - 0.0036 16.6 1.8 0.0044 16.4 1.8 1.0 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex Baculo_PEP_C PF04513.12 CCF41529.1 - 0.02 14.9 2.4 0.028 14.5 2.4 1.2 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1664 PF07889.12 CCF41529.1 - 0.02 14.9 1.9 0.028 14.5 1.4 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) DUF3037 PF11236.8 CCF41529.1 - 0.028 14.8 0.5 0.13 12.7 0.4 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3037) DUF3919 PF13057.6 CCF41529.1 - 0.043 13.4 0.1 0.056 13.0 0.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3919) HAUS5 PF14817.6 CCF41529.1 - 0.043 12.6 4.8 0.091 11.5 1.9 1.7 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 5 XhlA PF10779.9 CCF41529.1 - 0.063 13.5 1.6 0.6 10.4 0.5 2.2 2 0 0 2 2 2 0 Haemolysin XhlA DUF3450 PF11932.8 CCF41529.1 - 0.087 12.1 5.5 0.12 11.7 5.5 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) APG6_N PF17675.1 CCF41529.1 - 0.13 12.8 2.8 0.27 11.8 2.8 1.6 1 1 0 1 1 1 0 Apg6 coiled-coil region COG2 PF06148.11 CCF41529.1 - 0.17 12.0 4.1 1.3 9.1 4.1 2.0 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 Spectrin PF00435.21 CCF41529.1 - 0.34 11.4 3.1 0.88 10.1 2.0 2.1 1 1 1 2 2 2 0 Spectrin repeat DivIC PF04977.15 CCF41529.1 - 0.71 9.7 3.9 0.95 9.3 0.7 2.5 1 1 2 3 3 3 0 Septum formation initiator MIOX PF05153.15 CCF41530.1 - 2.6e-122 407.2 0.3 4.1e-122 406.5 0.3 1.3 1 0 0 1 1 1 1 Myo-inositol oxygenase HD PF01966.22 CCF41530.1 - 0.016 15.4 0.0 1.5 9.0 0.0 2.5 2 0 0 2 2 2 0 HD domain ISG65-75 PF11727.8 CCF41530.1 - 0.14 11.4 3.7 0.26 10.5 3.7 1.3 1 0 0 1 1 1 0 Invariant surface glycoprotein Fungal_trans_2 PF11951.8 CCF41531.1 - 1.2e-07 30.9 0.4 2.2e-07 30.1 0.1 1.5 2 0 0 2 2 2 1 Fungal specific transcription factor domain Sugar_tr PF00083.24 CCF41532.1 - 8.8e-83 278.6 19.6 1e-82 278.4 19.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF41532.1 - 4e-17 62.2 24.2 1.3e-14 53.9 21.4 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 CCF41532.1 - 0.001 17.8 2.7 0.001 17.8 2.7 2.4 2 0 0 2 2 2 1 MFS/sugar transport protein MFS_1_like PF12832.7 CCF41532.1 - 0.0016 17.3 6.8 0.0016 17.3 6.8 2.2 2 0 0 2 2 2 1 MFS_1 like family MFS_1 PF07690.16 CCF41533.1 - 8.8e-21 74.2 10.2 1e-20 74.0 10.2 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily SpoVAB PF13782.6 CCF41533.1 - 0.1 12.9 2.0 0.17 12.2 2.0 1.4 1 0 0 1 1 1 0 Stage V sporulation protein AB DUF3040 PF11239.8 CCF41533.1 - 0.18 12.1 1.8 16 5.8 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) COA2 PF17051.5 CCF41534.1 - 0.00018 21.5 0.0 0.00027 20.9 0.0 1.2 1 0 0 1 1 1 1 Cytochrome C oxidase assembly factor 2 Fungal_trans PF04082.18 CCF41535.1 - 1e-07 31.3 0.9 1.8e-07 30.5 0.9 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF41535.1 - 0.0016 18.6 2.7 0.0027 17.8 2.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RBR PF17208.3 CCF41535.1 - 0.15 12.8 0.6 0.86 10.4 0.6 2.3 1 0 0 1 1 1 0 RNA binding Region Presenilin PF01080.17 CCF41535.1 - 4.8 5.8 4.8 7.3 5.2 4.8 1.2 1 0 0 1 1 1 0 Presenilin Fungal_trans PF04082.18 CCF41536.1 - 8.5e-16 57.8 0.0 1.4e-15 57.1 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF5558 PF17713.1 CCF41536.1 - 0.1 13.0 0.3 0.33 11.3 0.1 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5558) Tim17 PF02466.19 CCF41537.1 - 4.6e-33 113.9 5.7 5.4e-33 113.7 5.7 1.0 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family USP7_ICP0_bdg PF12436.8 CCF41538.1 - 8e-89 297.1 0.1 1.2e-86 289.9 0.0 2.4 2 0 0 2 2 2 2 ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 PF14533.6 CCF41538.1 - 6.4e-80 267.7 1.5 1e-74 250.7 1.8 3.8 3 1 1 4 4 4 3 Ubiquitin-specific protease C-terminal Ald_Xan_dh_C2 PF02738.18 CCF41538.1 - 0.15 10.5 0.0 0.27 9.6 0.0 1.4 2 0 0 2 2 2 0 Molybdopterin-binding domain of aldehyde dehydrogenase Fungal_trans PF04082.18 CCF41539.1 - 1.1e-29 103.3 0.0 1.5e-29 102.9 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF41539.1 - 2.7e-07 30.6 10.2 2.7e-07 30.6 10.2 1.6 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain NMT1 PF09084.11 CCF41540.1 - 0.12 12.3 0.0 0.2 11.6 0.0 1.3 1 0 0 1 1 1 0 NMT1/THI5 like MFS_1 PF07690.16 CCF41541.1 - 6e-25 87.9 18.9 6e-25 87.9 18.9 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily CENP-Q PF13094.6 CCF41542.1 - 2.8e-51 174.1 0.4 2.8e-51 174.1 0.4 3.4 2 1 0 2 2 2 1 CENP-Q, a CENPA-CAD centromere complex subunit Formyl_trans_N PF00551.19 CCF41542.1 - 0.15 11.8 0.3 0.65 9.7 0.3 2.1 1 0 0 1 1 1 0 Formyl transferase ABC_tran PF00005.27 CCF41543.1 - 5.4e-49 166.2 0.5 9.3e-25 87.7 0.1 3.6 2 2 0 2 2 2 2 ABC transporter 4HB PF17947.1 CCF41543.1 - 9.8e-27 92.8 1.1 2.3e-26 91.6 1.1 1.7 1 0 0 1 1 1 1 Four helical bundle domain AAA_21 PF13304.6 CCF41543.1 - 9.2e-19 68.4 0.0 0.0016 18.3 0.0 5.1 5 0 0 5 5 5 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CCF41543.1 - 2.3e-17 63.2 1.2 4.3e-06 26.3 0.1 4.0 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CCF41543.1 - 9.9e-11 42.5 2.7 0.00014 22.4 0.2 3.2 2 1 0 2 2 2 2 AAA domain AAA_29 PF13555.6 CCF41543.1 - 5.1e-09 35.7 0.0 0.004 16.9 0.0 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CCF41543.1 - 2.8e-08 33.9 0.3 0.00041 20.3 0.0 2.9 2 1 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 CCF41543.1 - 1.7e-07 31.3 0.0 0.0021 18.1 0.0 3.0 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_22 PF13401.6 CCF41543.1 - 3.1e-07 30.7 0.1 0.0062 16.8 0.0 3.2 4 0 0 4 4 2 2 AAA domain AAA_28 PF13521.6 CCF41543.1 - 7.8e-07 29.5 0.0 0.02 15.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_15 PF13175.6 CCF41543.1 - 1.5e-06 28.2 0.4 0.053 13.2 0.0 3.5 3 1 0 4 4 4 2 AAA ATPase domain Dynamin_N PF00350.23 CCF41543.1 - 2e-06 28.0 0.0 0.00089 19.3 0.0 2.7 2 0 0 2 2 2 1 Dynamin family AAA_18 PF13238.6 CCF41543.1 - 6.6e-06 26.7 0.1 0.11 13.1 0.0 3.2 3 0 0 3 3 2 2 AAA domain AAA PF00004.29 CCF41543.1 - 1.2e-05 25.7 0.2 0.35 11.3 0.1 4.1 4 1 0 4 4 3 1 ATPase family associated with various cellular activities (AAA) MeaB PF03308.16 CCF41543.1 - 2.6e-05 23.3 0.1 0.19 10.7 0.0 2.4 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_33 PF13671.6 CCF41543.1 - 3.4e-05 24.0 0.0 0.44 10.7 0.0 2.9 2 0 0 2 2 2 2 AAA domain PduV-EutP PF10662.9 CCF41543.1 - 3.5e-05 23.6 0.1 0.049 13.4 0.0 3.1 2 1 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation RNA_helicase PF00910.22 CCF41543.1 - 4.6e-05 23.8 0.0 0.66 10.4 0.0 3.1 3 0 0 3 3 2 2 RNA helicase AAA_16 PF13191.6 CCF41543.1 - 5.1e-05 23.7 0.1 0.33 11.3 0.0 3.2 4 0 0 4 4 2 2 AAA ATPase domain AAA_27 PF13514.6 CCF41543.1 - 0.00014 21.6 0.0 0.11 12.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain G-alpha PF00503.20 CCF41543.1 - 0.00019 20.7 0.3 0.54 9.4 0.0 2.6 1 1 0 2 2 2 2 G-protein alpha subunit NACHT PF05729.12 CCF41543.1 - 0.00033 20.6 0.0 0.12 12.3 0.0 2.5 2 0 0 2 2 2 1 NACHT domain AAA_24 PF13479.6 CCF41543.1 - 0.00046 20.0 0.1 0.87 9.3 0.0 3.0 3 0 0 3 3 2 2 AAA domain AAA_14 PF13173.6 CCF41543.1 - 0.0008 19.4 0.0 3.3 7.8 0.0 3.3 3 0 0 3 3 3 1 AAA domain AAA_30 PF13604.6 CCF41543.1 - 0.00083 19.1 0.0 2.5 7.8 0.0 3.0 3 0 0 3 3 3 2 AAA domain Rad17 PF03215.15 CCF41543.1 - 0.0011 19.0 0.0 1.3 8.9 0.0 2.6 2 0 0 2 2 2 1 Rad17 P-loop domain DUF87 PF01935.17 CCF41543.1 - 0.0011 19.1 0.0 0.75 9.8 0.0 3.2 3 0 0 3 3 2 1 Helicase HerA, central domain SbcCD_C PF13558.6 CCF41543.1 - 0.0019 18.4 0.0 0.88 9.8 0.0 3.2 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit NB-ARC PF00931.22 CCF41543.1 - 0.0025 17.0 0.0 0.22 10.6 0.0 2.5 2 0 0 2 2 2 1 NB-ARC domain PRK PF00485.18 CCF41543.1 - 0.0028 17.4 0.0 0.19 11.5 0.0 2.4 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family ATPase_2 PF01637.18 CCF41543.1 - 0.0047 16.9 0.9 1.5 8.6 0.1 3.1 3 1 0 3 3 2 1 ATPase domain predominantly from Archaea cobW PF02492.19 CCF41543.1 - 0.0047 16.5 0.0 3.4 7.2 0.0 2.8 3 0 0 3 3 2 1 CobW/HypB/UreG, nucleotide-binding domain Roc PF08477.13 CCF41543.1 - 0.0048 17.1 0.0 5.7 7.2 0.0 2.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase ATP_bind_1 PF03029.17 CCF41543.1 - 0.0078 16.0 0.0 6.1 6.5 0.0 2.8 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein CLP1_P PF16575.5 CCF41543.1 - 0.0095 15.7 0.0 0.67 9.7 0.0 2.7 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop Ploopntkinase3 PF18751.1 CCF41543.1 - 0.011 15.7 0.1 2.5 8.0 0.0 2.4 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 IstB_IS21 PF01695.17 CCF41543.1 - 0.011 15.4 0.0 4.6 6.9 0.0 2.8 3 0 0 3 3 2 0 IstB-like ATP binding protein Septin PF00735.18 CCF41543.1 - 0.011 15.0 0.0 1.7 7.9 0.0 2.4 2 0 0 2 2 2 0 Septin AAA_7 PF12775.7 CCF41543.1 - 0.011 15.2 0.0 3.2 7.2 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region Mg_chelatase PF01078.21 CCF41543.1 - 0.028 13.8 0.0 3.6 6.9 0.0 3.1 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI AAA_13 PF13166.6 CCF41543.1 - 0.03 13.0 4.7 1.8 7.1 0.0 3.6 4 0 0 4 4 3 0 AAA domain ATP-synt_ab PF00006.25 CCF41543.1 - 0.033 13.9 0.0 11 5.6 0.0 2.4 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain T2SSE PF00437.20 CCF41543.1 - 0.035 13.2 0.0 3.5 6.6 0.0 2.5 2 0 0 2 2 2 0 Type II/IV secretion system protein Cytidylate_kin PF02224.18 CCF41543.1 - 0.04 13.6 0.0 10 5.8 0.0 2.5 2 0 0 2 2 2 0 Cytidylate kinase NTPase_1 PF03266.15 CCF41543.1 - 0.045 13.6 0.1 13 5.6 0.0 2.8 2 0 0 2 2 2 0 NTPase Zeta_toxin PF06414.12 CCF41543.1 - 0.05 12.9 0.1 9.9 5.4 0.0 2.8 3 0 0 3 3 2 0 Zeta toxin AAA_25 PF13481.6 CCF41543.1 - 0.06 12.9 0.0 7.3 6.1 0.0 2.9 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 CCF41543.1 - 0.061 13.3 0.1 39 4.3 0.0 3.3 2 1 1 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE MukB PF04310.12 CCF41543.1 - 0.065 13.0 0.0 9.3 6.0 0.0 2.3 2 0 0 2 2 2 0 MukB N-terminal DUF815 PF05673.13 CCF41543.1 - 0.069 12.3 0.0 8.8 5.4 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF815) DUF1280 PF06918.14 CCF41543.1 - 0.093 12.3 0.6 0.35 10.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1280) FeoB_N PF02421.18 CCF41543.1 - 0.12 11.9 0.1 1.1 8.8 0.1 2.3 2 0 0 2 2 2 0 Ferrous iron transport protein B Acetyltransf_3 PF13302.7 CCF41544.1 - 5.2e-25 88.7 0.0 7.3e-25 88.2 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 CCF41544.1 - 2.2e-06 27.4 2.1 0.35 10.6 0.5 3.1 3 0 0 3 3 3 3 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CCF41544.1 - 1.1e-05 25.7 0.4 0.00088 19.5 0.2 2.4 1 1 1 2 2 2 1 Acetyltransferase (GNAT) family FR47 PF08445.10 CCF41544.1 - 4.6e-05 23.3 0.2 0.11 12.5 0.0 2.3 2 0 0 2 2 2 2 FR47-like protein Acetyltransf_7 PF13508.7 CCF41544.1 - 0.011 16.1 0.1 0.024 15.1 0.1 1.6 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CCF41544.1 - 0.034 14.1 0.1 5.4 7.0 0.0 2.3 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain PALP PF00291.25 CCF41545.1 - 1e-08 35.0 0.5 1.1e-08 34.8 0.5 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme GCV_T_C PF08669.11 CCF41545.1 - 0.065 13.2 0.1 0.09 12.7 0.1 1.3 1 0 0 1 1 1 0 Glycine cleavage T-protein C-terminal barrel domain MTHFR PF02219.17 CCF41546.1 - 4.2e-111 370.9 0.0 6.1e-111 370.3 0.0 1.2 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase Ribonuclease_3 PF00636.26 CCF41547.1 - 4.4e-46 155.8 0.0 1.7e-23 83.2 0.0 3.5 3 0 0 3 3 3 2 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 CCF41547.1 - 2.9e-26 92.1 0.0 7.9e-11 42.2 0.0 3.8 3 0 0 3 3 3 3 Ribonuclease-III-like Dicer_dimer PF03368.14 CCF41547.1 - 5.4e-21 74.6 0.1 3.6e-19 68.7 0.1 3.2 3 0 0 3 3 3 1 Dicer dimerisation domain Helicase_C PF00271.31 CCF41547.1 - 5.9e-18 65.2 0.1 2.3e-17 63.3 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCF41547.1 - 9.9e-15 55.0 0.3 3e-14 53.4 0.2 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 CCF41547.1 - 4.9e-10 39.4 0.0 1.1e-09 38.4 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase SWI2_SNF2 PF18766.1 CCF41547.1 - 0.04 13.6 0.0 0.079 12.6 0.0 1.4 1 0 0 1 1 1 0 SWI2/SNF2 ATPase ERCC3_RAD25_C PF16203.5 CCF41547.1 - 0.055 12.7 0.0 0.12 11.6 0.0 1.5 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase Flavi_DEAD PF07652.14 CCF41547.1 - 0.11 12.4 1.2 0.42 10.6 0.1 2.4 3 0 0 3 3 3 0 Flavivirus DEAD domain dsrm PF00035.26 CCF41547.1 - 0.15 12.8 1.0 8.2 7.2 0.5 2.7 2 0 0 2 2 2 0 Double-stranded RNA binding motif TAP42 PF04177.12 CCF41548.1 - 3.2e-105 351.8 0.1 3.6e-105 351.6 0.1 1.0 1 0 0 1 1 1 1 TAP42-like family ELM2 PF01448.24 CCF41548.1 - 0.013 16.2 0.5 0.06 14.1 0.0 2.3 2 0 0 2 2 2 0 ELM2 domain NAD_binding_8 PF13450.6 CCF41549.1 - 4e-07 30.2 0.0 4.9e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FMO-like PF00743.19 CCF41549.1 - 9.3e-07 27.6 0.0 1.3e-06 27.2 0.0 1.1 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like DAO PF01266.24 CCF41549.1 - 4.8e-05 23.1 0.0 6.2e-05 22.7 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 CCF41549.1 - 0.0004 20.4 0.0 0.0008 19.4 0.0 1.6 1 1 0 1 1 1 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 CCF41549.1 - 0.00076 18.8 0.0 0.00076 18.8 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 CCF41549.1 - 0.0048 16.2 0.1 0.007 15.6 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 CCF41549.1 - 0.012 14.9 0.0 0.013 14.7 0.0 1.1 1 0 0 1 1 1 0 Thi4 family Pyr_redox_3 PF13738.6 CCF41549.1 - 0.02 14.2 0.0 0.02 14.2 0.0 1.2 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 CCF41549.1 - 0.032 13.5 0.0 0.038 13.3 0.0 1.1 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase Lycopene_cycl PF05834.12 CCF41549.1 - 0.14 11.2 0.0 0.14 11.2 0.0 1.1 1 0 0 1 1 1 0 Lycopene cyclase protein HI0933_like PF03486.14 CCF41549.1 - 0.15 10.7 0.0 0.16 10.6 0.0 1.1 1 0 0 1 1 1 0 HI0933-like protein Diphthamide_syn PF01866.17 CCF41551.1 - 1.8e-87 293.6 0.0 2.2e-87 293.3 0.0 1.0 1 0 0 1 1 1 1 Putative diphthamide synthesis protein zf-C2H2_4 PF13894.6 CCF41553.1 - 0.19 12.7 0.1 0.19 12.7 0.1 3.1 2 1 0 2 2 2 0 C2H2-type zinc finger Utp14 PF04615.13 CCF41556.1 - 0.1 11.1 31.2 0.12 10.9 31.2 1.0 1 0 0 1 1 1 0 Utp14 protein adh_short_C2 PF13561.6 CCF41558.1 - 4e-17 62.5 0.0 4.6e-17 62.4 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF41558.1 - 4.6e-17 62.1 0.0 6.3e-17 61.7 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase DUF4010 PF13194.6 CCF41558.1 - 0.06 13.0 0.2 0.082 12.6 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4010) Dishevelled PF02377.15 CCF41559.1 - 0.065 13.7 0.2 0.13 12.7 0.2 1.5 1 0 0 1 1 1 0 Dishevelled specific domain SWIB PF02201.18 CCF41559.1 - 0.093 12.6 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 SWIB/MDM2 domain Pkinase PF00069.25 CCF41560.1 - 1.4e-24 86.8 0.0 2.1e-24 86.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF41560.1 - 3.9e-09 36.2 0.0 6.6e-08 32.2 0.0 2.1 1 1 1 2 2 2 1 Protein tyrosine kinase Chitin_synth_2 PF03142.15 CCF41561.1 - 3.7e-79 266.7 0.0 5.3e-79 266.2 0.0 1.1 1 0 0 1 1 1 1 Chitin synthase Cyt-b5 PF00173.28 CCF41561.1 - 4e-14 52.5 1.0 6.2e-09 35.9 0.0 3.3 3 1 0 3 3 3 2 Cytochrome b5-like Heme/Steroid binding domain Myosin_head PF00063.21 CCF41561.1 - 2.5e-08 32.6 0.0 8.7e-08 30.9 0.0 1.7 1 1 0 1 1 1 1 Myosin head (motor domain) ANAPC4_WD40 PF12894.7 CCF41562.1 - 5.7e-18 65.0 0.0 5.6e-05 23.4 0.0 5.5 4 2 2 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CCF41562.1 - 1e-17 64.2 16.0 0.0011 19.7 0.1 7.1 7 0 0 7 7 7 4 WD domain, G-beta repeat eIF2A PF08662.11 CCF41562.1 - 4.3e-05 23.5 0.2 0.021 14.7 0.0 3.0 3 0 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A Coatomer_WDAD PF04053.14 CCF41562.1 - 0.013 14.6 0.0 0.16 11.0 0.0 2.3 3 0 0 3 3 3 0 Coatomer WD associated region Ge1_WD40 PF16529.5 CCF41562.1 - 0.081 11.9 0.1 22 3.9 0.0 3.4 2 1 2 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 CCF41562.1 - 0.11 11.8 0.0 0.23 10.7 0.0 1.6 1 0 0 1 1 1 0 WD40-like domain HIRA_B PF09453.10 CCF41562.1 - 1.7 8.6 5.7 0.27 11.1 1.1 2.2 2 0 0 2 2 2 0 HIRA B motif ABC_membrane PF00664.23 CCF41563.1 - 1.8e-26 93.4 2.3 1.9e-26 93.4 2.3 1.0 1 0 0 1 1 1 1 ABC transporter transmembrane region DUF2975 PF11188.8 CCF41563.1 - 1.3 8.9 6.2 10 6.0 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2975) COesterase PF00135.28 CCF41565.1 - 1.3e-70 238.8 0.0 1.7e-70 238.3 0.0 1.2 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CCF41565.1 - 0.0034 17.3 6.3 0.098 12.5 5.9 3.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CCF41565.1 - 0.0069 15.9 0.3 0.019 14.5 0.3 1.7 1 0 0 1 1 1 1 Prolyl oligopeptidase family Glyco_hydro_47 PF01532.20 CCF41566.1 - 7.7e-144 480.0 0.0 9e-144 479.8 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Abhydrolase_1 PF00561.20 CCF41570.1 - 3.2e-11 43.4 0.0 6.7e-11 42.3 0.0 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCF41570.1 - 7.4e-09 36.5 0.0 9.4e-09 36.2 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCF41570.1 - 1.5e-07 30.9 0.0 3.9e-07 29.6 0.0 1.7 1 1 1 2 2 2 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 CCF41570.1 - 0.0034 17.5 0.0 0.005 17.0 0.0 1.4 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_2 PF02230.16 CCF41570.1 - 0.053 13.3 0.0 0.75 9.6 0.0 2.6 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase Abhydrolase_3 PF07859.13 CCF41570.1 - 0.086 12.7 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold PGAP1 PF07819.13 CCF41570.1 - 0.11 12.2 0.0 0.33 10.6 0.0 1.7 1 1 0 1 1 1 0 PGAP1-like protein Esterase PF00756.20 CCF41570.1 - 0.13 11.9 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 Putative esterase S-AdoMet_synt_C PF02773.16 CCF41574.1 - 1.9e-66 222.3 0.4 5.9e-66 220.7 0.0 1.7 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.16 CCF41574.1 - 2.9e-19 69.5 0.0 4.5e-19 68.9 0.0 1.2 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain SPOUT_MTase PF02590.17 CCF41574.1 - 0.068 13.2 0.0 0.1 12.6 0.0 1.2 1 0 0 1 1 1 0 Predicted SPOUT methyltransferase PI-PLC-X PF00388.19 CCF41577.1 - 4.8e-09 36.0 0.0 7.6e-09 35.3 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain RhoGEF PF00621.20 CCF41578.1 - 2.9e-13 50.4 0.0 5.5e-13 49.6 0.0 1.4 1 0 0 1 1 1 1 RhoGEF domain E1-E2_ATPase PF00122.20 CCF41579.1 - 2.5e-51 173.7 4.9 3.8e-51 173.2 1.6 2.6 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 CCF41579.1 - 8.6e-46 155.9 4.3 8.6e-46 155.9 4.3 1.6 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 CCF41579.1 - 5.3e-25 88.9 0.6 2.1e-23 83.7 0.6 2.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CCF41579.1 - 2.6e-19 69.1 0.0 6.5e-19 67.8 0.0 1.7 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 CCF41579.1 - 8.6e-18 63.8 0.0 2.2e-17 62.5 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 CCF41579.1 - 8.2e-09 35.6 1.1 3e-06 27.2 0.8 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 CCF41579.1 - 3.3e-06 27.6 0.0 1.2e-05 25.8 0.0 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Proteasome PF00227.26 CCF41580.1 - 2.6e-40 138.0 0.0 3.1e-40 137.7 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit TUG-UBL1 PF11470.8 CCF41581.1 - 1.7e-25 89.0 0.1 3.4e-25 88.0 0.1 1.5 1 0 0 1 1 1 1 TUG ubiquitin-like domain RBD PF02196.15 CCF41581.1 - 0.00044 20.3 0.1 0.00095 19.2 0.1 1.5 1 0 0 1 1 1 1 Raf-like Ras-binding domain DUF4294 PF14127.6 CCF41581.1 - 0.003 17.5 0.1 0.0065 16.4 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4294) UBX PF00789.20 CCF41581.1 - 0.0064 16.7 0.0 0.037 14.2 0.0 2.1 2 0 0 2 2 2 1 UBX domain Rad60-SLD PF11976.8 CCF41581.1 - 0.16 11.8 0.0 0.31 10.9 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Ribosomal_L36e PF01158.18 CCF41582.1 - 2.5e-42 143.0 6.1 2.9e-42 142.8 6.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L36e MRP-L28 PF09812.9 CCF41582.1 - 0.012 15.8 1.5 0.014 15.6 1.5 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L28 PBS_linker_poly PF00427.21 CCF41582.1 - 0.051 13.6 0.2 0.056 13.5 0.2 1.1 1 0 0 1 1 1 0 Phycobilisome Linker polypeptide AltA1 PF16541.5 CCF41583.1 - 0.003 18.4 0.1 0.0059 17.4 0.0 1.5 1 1 1 2 2 2 1 Alternaria alternata allergen 1 Lipase_3 PF01764.25 CCF41584.1 - 4.7e-30 104.3 0.0 6.7e-30 103.8 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) Thioesterase PF00975.20 CCF41584.1 - 0.00019 21.6 0.0 0.00033 20.8 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_6 PF12697.7 CCF41584.1 - 0.00042 21.0 0.0 0.00067 20.3 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCF41584.1 - 0.00066 19.0 0.0 0.001 18.4 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF2974 PF11187.8 CCF41584.1 - 0.012 15.2 0.0 0.15 11.6 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) Abhydrolase_1 PF00561.20 CCF41584.1 - 0.028 14.1 0.0 0.053 13.2 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold PGAP1 PF07819.13 CCF41584.1 - 0.12 12.0 0.0 0.18 11.5 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein Translin PF01997.16 CCF41586.1 - 8.2e-12 45.5 0.0 9.5e-12 45.3 0.0 1.1 1 0 0 1 1 1 1 Translin family ApbA_C PF08546.11 CCF41586.1 - 0.0071 16.5 0.0 0.01 16.1 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal APG17 PF04108.12 CCF41586.1 - 0.015 14.4 0.1 0.019 14.1 0.1 1.1 1 0 0 1 1 1 0 Autophagy protein Apg17 LIF_OSM PF01291.17 CCF41586.1 - 0.043 14.0 0.0 0.062 13.5 0.0 1.2 1 0 0 1 1 1 0 LIF / OSM family TMPIT PF07851.13 CCF41586.1 - 0.068 12.4 0.3 0.11 11.7 0.2 1.2 1 1 0 1 1 1 0 TMPIT-like protein DUF3863 PF12979.7 CCF41586.1 - 0.081 11.8 0.0 0.13 11.1 0.0 1.3 1 1 0 1 1 1 0 Domain of Unknown Function with PDB structure (DUF3863) Fungal_trans PF04082.18 CCF41587.1 - 7.1e-27 94.1 0.1 1e-26 93.6 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF41587.1 - 0.00078 19.5 1.9 0.0017 18.5 1.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PRIMA1 PF16101.5 CCF41587.1 - 0.092 12.8 0.5 0.21 11.7 0.5 1.5 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 ILVD_EDD PF00920.21 CCF41588.1 - 5.9e-10 38.4 0.2 6.4e-10 38.3 0.2 1.0 1 0 0 1 1 1 1 Dehydratase family Tli4_N PF18443.1 CCF41588.1 - 0.057 13.8 0.0 0.057 13.8 0.0 1.1 1 0 0 1 1 1 0 Tle cognate immunity protein 4 N-terminal domain AAA_33 PF13671.6 CCF41588.1 - 0.093 12.9 0.4 0.13 12.5 0.4 1.2 1 0 0 1 1 1 0 AAA domain adh_short_C2 PF13561.6 CCF41589.1 - 1.4e-37 129.5 0.1 2.4e-37 128.7 0.1 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF41589.1 - 2.2e-36 125.1 0.0 2.8e-36 124.8 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF41589.1 - 0.0078 16.1 0.0 0.014 15.4 0.0 1.5 1 1 0 1 1 1 1 KR domain DUF1482 PF07358.11 CCF41589.1 - 0.023 14.6 0.1 0.045 13.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1482) Ank_5 PF13857.6 CCF41590.1 - 7.7e-13 48.4 0.1 3.2e-09 36.9 0.1 2.4 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 CCF41590.1 - 1.5e-11 44.8 0.0 2.5e-11 44.0 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 CCF41590.1 - 2.3e-11 43.6 0.6 1e-08 35.2 0.3 3.1 3 0 0 3 3 3 1 Ankyrin repeat Ank_3 PF13606.6 CCF41590.1 - 1.1e-10 40.8 0.0 1.1e-06 28.5 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 CCF41590.1 - 3e-10 40.4 0.2 3.8e-05 24.1 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) zf-C2H2 PF00096.26 CCF41591.1 - 0.058 13.9 0.1 0.058 13.9 0.1 3.8 4 0 0 4 4 4 0 Zinc finger, C2H2 type TauD PF02668.16 CCF41592.1 - 2e-33 116.3 0.0 2.6e-33 115.9 0.0 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family RRM_1 PF00076.22 CCF41594.1 - 1.1e-33 114.9 0.0 1.8e-15 56.5 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CCF41594.1 - 0.0008 19.5 0.0 0.0024 17.9 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif Nup35_RRM_2 PF14605.6 CCF41594.1 - 0.0083 16.1 0.0 0.029 14.4 0.0 1.9 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif OB_RNB PF08206.11 CCF41594.1 - 0.009 15.7 0.8 2 8.2 0.1 2.6 2 0 0 2 2 2 2 Ribonuclease B OB domain RRM_5 PF13893.6 CCF41594.1 - 0.012 15.2 0.0 0.13 11.9 0.0 2.1 1 1 1 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Tom7 PF08038.12 CCF41595.1 - 1.6e-20 72.5 0.4 1.8e-20 72.3 0.4 1.1 1 0 0 1 1 1 1 TOM7 family DUF5049 PF16468.5 CCF41595.1 - 0.13 12.2 0.0 0.16 11.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5049) Mito_carr PF00153.27 CCF41596.1 - 6.1e-53 176.7 1.3 1.6e-18 66.4 0.2 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein PrcB_C PF14343.6 CCF41596.1 - 0.2 11.8 0.1 3.2 8.0 0.1 2.3 2 0 0 2 2 2 0 PrcB C-terminal Fungal_trans_2 PF11951.8 CCF41597.1 - 3.7e-17 62.2 0.0 4.5e-17 61.9 0.0 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain Phytase PF02333.15 CCF41599.1 - 2.9e-25 89.0 0.0 5.6e-24 84.8 0.0 2.2 2 0 0 2 2 2 1 Phytase EGF_2 PF07974.13 CCF41599.1 - 4e-07 30.3 34.6 0.00039 20.7 15.3 2.5 2 0 0 2 2 2 2 EGF-like domain BetaGal_dom2 PF10435.9 CCF41600.1 - 1.6e-56 191.0 1.5 2.4e-56 190.4 1.5 1.3 1 0 0 1 1 1 1 Beta-galactosidase, domain 2 BetaGal_dom4_5 PF13364.6 CCF41600.1 - 1.8e-50 170.3 2.5 3.9e-30 104.7 0.0 2.9 3 0 0 3 3 3 2 Beta-galactosidase jelly roll domain BetaGal_dom3 PF13363.6 CCF41600.1 - 6e-23 80.2 0.0 3.1e-22 77.9 0.0 2.1 2 0 0 2 2 2 1 Beta-galactosidase, domain 3 Glyco_hydro_35 PF01301.19 CCF41600.1 - 3.2e-22 79.5 0.0 5.1e-22 78.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 DUF1682 PF07946.14 CCF41602.1 - 0.098 11.8 3.6 0.11 11.7 3.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) CDC45 PF02724.14 CCF41604.1 - 0.58 8.4 4.5 0.75 8.0 4.5 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF2457 PF10446.9 CCF41604.1 - 6.8 5.7 12.9 9.9 5.2 12.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) WD40 PF00400.32 CCF41605.1 - 7.6e-61 200.6 13.9 3.6e-09 37.1 0.1 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF41605.1 - 1.9e-16 60.2 0.0 0.0002 21.6 0.0 5.4 2 1 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CCF41605.1 - 1e-08 34.6 0.3 0.085 11.8 0.0 5.3 2 2 4 6 6 6 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 CCF41605.1 - 2.9e-06 26.8 0.0 0.19 11.0 0.0 4.7 4 1 1 5 5 5 2 WD40-like domain Nup160 PF11715.8 CCF41605.1 - 0.0011 17.7 0.2 0.96 8.0 0.0 3.8 1 1 2 4 4 4 1 Nucleoporin Nup120/160 PD40 PF07676.12 CCF41605.1 - 0.0034 17.3 0.0 5.5 7.0 0.0 4.4 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 CCF41605.1 - 0.0038 16.6 0.1 4.6 6.5 0.0 3.2 2 1 1 3 3 3 2 Neuroblastoma-amplified sequence, N terminal Cytochrom_D1 PF02239.16 CCF41605.1 - 0.007 14.9 0.6 0.17 10.4 0.2 2.7 2 1 2 4 4 4 2 Cytochrome D1 heme domain Nucleoporin_N PF08801.11 CCF41605.1 - 0.0072 15.1 0.1 1.1 7.9 0.1 3.5 2 1 1 3 3 3 1 Nup133 N terminal like Mcl1_mid PF12341.8 CCF41605.1 - 0.072 12.4 0.1 0.25 10.6 0.0 1.8 2 0 0 2 2 2 0 Minichromosome loss protein, Mcl1, middle region Glyco_hydro_61 PF03443.14 CCF41607.1 - 2.8e-64 216.8 0.1 4e-64 216.3 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 DUF4106 PF13388.6 CCF41607.1 - 1.7 7.8 4.9 3 7.0 4.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) Ceramidase_alk PF04734.13 CCF41608.1 - 1.4e-221 736.6 0.0 1.6e-221 736.4 0.0 1.0 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, N-terminal Ceramidse_alk_C PF17048.5 CCF41608.1 - 9e-07 28.9 0.0 1.5e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, C-terminal SAYSvFN PF10260.9 CCF41608.1 - 0.44 10.5 1.6 0.48 10.4 0.0 1.8 2 0 0 2 2 2 0 Uncharacterized conserved domain (SAYSvFN) ATG16 PF08614.11 CCF41609.1 - 1.1 9.5 7.9 0.15 12.2 2.0 2.0 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) Stm1_N PF09598.10 CCF41609.1 - 8.6 7.3 9.5 11 7.0 2.0 2.7 2 0 0 2 2 2 0 Stm1 SPC22 PF04573.12 CCF41611.1 - 5.8e-40 136.6 2.0 6.8e-39 133.1 2.0 1.9 1 1 0 1 1 1 1 Signal peptidase subunit XRN1_D2_D3 PF18334.1 CCF41612.1 - 1.2e-35 121.5 0.0 2.5e-35 120.5 0.0 1.6 1 0 0 1 1 1 1 Exoribonuclease Xrn1 D2/D3 domain SH3_12 PF18129.1 CCF41612.1 - 6e-23 80.7 0.1 1.2e-22 79.7 0.1 1.6 1 0 0 1 1 1 1 Xrn1 SH3-like domain XRN1_D1 PF18332.1 CCF41612.1 - 5.6e-14 52.3 0.0 9.1e-14 51.7 0.0 1.4 1 0 0 1 1 1 1 Exoribonuclease Xrn1 D1 domain Xrn1_D3 PF18194.1 CCF41612.1 - 1.1e-06 28.6 0.1 3.2e-06 27.2 0.0 1.8 2 0 0 2 2 2 1 Exoribonuclease 1 Domain-3 Mito_carr PF00153.27 CCF41614.1 - 7.4e-38 128.4 4.3 4.8e-19 68.1 0.0 2.7 3 0 0 3 3 3 2 Mitochondrial carrier protein Suv3_N PF18114.1 CCF41614.1 - 0.19 11.9 0.0 0.3 11.2 0.0 1.2 1 0 0 1 1 1 0 Suv3 helical N-terminal domain WD40 PF00400.32 CCF41615.1 - 3.3e-18 65.7 1.6 2.2e-07 31.4 0.1 5.9 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF41615.1 - 9.4e-06 25.8 0.0 0.29 11.4 0.0 4.3 2 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain p450 PF00067.22 CCF41616.1 - 3.2e-06 26.2 0.0 3.5e-06 26.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 FAA_hydrolase_N PF09298.11 CCF41616.1 - 0.11 12.6 0.1 0.31 11.3 0.1 1.8 1 1 1 2 2 2 0 Fumarylacetoacetase N-terminal G_glu_transpept PF01019.21 CCF41617.1 - 6.9e-159 529.9 0.2 7.9e-159 529.7 0.2 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase RPE65 PF03055.15 CCF41618.1 - 4.6e-62 210.7 0.0 5.5e-62 210.5 0.0 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein DUF4437 PF14499.6 CCF41619.1 - 0.056 12.5 0.1 0.072 12.2 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4437) NAD_binding_8 PF13450.6 CCF41621.1 - 2.1e-12 47.1 0.3 5.4e-12 45.8 0.3 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 CCF41621.1 - 2e-08 33.7 4.4 3.6e-08 32.9 4.4 1.3 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 CCF41621.1 - 2.3e-07 30.6 3.0 3.4e-07 30.0 3.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCF41621.1 - 1.2e-06 28.0 0.1 5.1e-06 25.9 0.1 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCF41621.1 - 1.4e-06 28.2 4.5 1.7e-06 27.9 2.6 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase Amino_oxidase PF01593.24 CCF41621.1 - 2.3e-06 27.2 0.1 5e-05 22.8 0.0 2.0 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase HI0933_like PF03486.14 CCF41621.1 - 6.8e-06 25.0 0.8 1.1e-05 24.3 0.8 1.3 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_3 PF01494.19 CCF41621.1 - 0.00013 21.4 1.8 0.00018 20.9 1.3 1.5 1 1 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 CCF41621.1 - 0.00021 21.8 0.5 0.00053 20.5 0.5 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CCF41621.1 - 0.002 17.4 0.4 0.0051 16.1 0.5 1.5 2 0 0 2 2 2 1 Thi4 family Pyr_redox_3 PF13738.6 CCF41621.1 - 0.0021 17.4 0.2 0.0047 16.2 0.2 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CCF41621.1 - 0.0052 15.9 1.3 0.0074 15.4 1.3 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 CCF41621.1 - 0.056 12.7 0.5 0.1 11.9 0.5 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Trp_halogenase PF04820.14 CCF41621.1 - 0.062 12.1 1.5 0.1 11.4 1.5 1.3 1 0 0 1 1 1 0 Tryptophan halogenase Lycopene_cycl PF05834.12 CCF41621.1 - 0.075 12.1 0.2 0.11 11.5 0.2 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein NAD_binding_7 PF13241.6 CCF41621.1 - 0.13 12.7 0.0 0.25 11.8 0.0 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding COMPASS-Shg1 PF05205.12 CCF41623.1 - 0.016 15.9 1.6 0.016 15.9 1.6 2.1 1 1 1 2 2 2 0 COMPASS (Complex proteins associated with Set1p) component shg1 DUF4041 PF13250.6 CCF41623.1 - 0.021 14.7 0.4 0.84 9.6 0.1 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4041) DUF4507 PF14964.6 CCF41623.1 - 0.32 9.9 3.3 0.26 10.2 1.9 1.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4507) MDH PF02315.16 CCF41624.1 - 0.018 15.1 0.1 0.021 14.9 0.1 1.1 1 0 0 1 1 1 0 Methanol dehydrogenase beta subunit DUF2236 PF09995.9 CCF41625.1 - 9.2e-08 32.6 0.2 1.6e-07 31.7 0.2 1.3 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2236) DUF1180 PF06679.12 CCF41625.1 - 0.35 11.3 0.9 0.58 10.6 0.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Spc7_N PF15402.6 CCF41627.1 - 1.7e-94 317.9 60.1 2.6e-92 310.7 60.1 2.7 1 1 0 1 1 1 1 N-terminus of kinetochore NMS complex subunit Spc7 Ribosomal_S17_N PF16205.5 CCF41628.1 - 1.5e-32 111.8 0.5 2.5e-32 111.1 0.5 1.4 1 0 0 1 1 1 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.20 CCF41628.1 - 9.5e-27 92.9 0.2 2.1e-26 91.8 0.2 1.6 1 0 0 1 1 1 1 Ribosomal protein S17 Fungal_trans PF04082.18 CCF41629.1 - 1.1e-22 80.3 0.0 1.8e-22 79.7 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF41629.1 - 4.8e-08 33.0 13.7 8e-08 32.3 13.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Tmemb_cc2 PF10267.9 CCF41629.1 - 0.006 15.8 0.1 0.0076 15.4 0.1 1.1 1 0 0 1 1 1 1 Predicted transmembrane and coiled-coil 2 protein Zn_clus PF00172.18 CCF41630.1 - 3.4e-07 30.3 11.9 5.5e-07 29.6 11.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SIS PF01380.22 CCF41631.1 - 1.7e-59 199.4 0.2 9.7e-32 109.6 0.1 2.3 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.6 CCF41631.1 - 1.1e-17 64.5 0.0 2.2e-17 63.5 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 CCF41631.1 - 1.1e-10 41.5 0.0 2.8e-10 40.2 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.6 CCF41631.1 - 0.00084 18.3 0.0 0.0014 17.6 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II CAP18_C PF12153.8 CCF41631.1 - 0.11 12.4 0.2 0.26 11.2 0.2 1.5 1 0 0 1 1 1 0 LPS binding domain of CAP18 (C terminal) PTSIIB_sorb PF03830.15 CCF41631.1 - 0.15 12.2 0.1 0.67 10.2 0.0 2.0 2 0 0 2 2 2 0 PTS system sorbose subfamily IIB component Glyco_hydro_43 PF04616.14 CCF41632.1 - 4.4e-08 32.8 4.2 7.5e-08 32.0 4.2 1.4 1 1 0 1 1 1 1 Glycosyl hydrolases family 43 Dpy-30 PF05186.13 CCF41635.1 - 5.7e-12 45.1 0.0 7.7e-12 44.7 0.0 1.2 1 0 0 1 1 1 1 Dpy-30 motif Ribosomal_S13_N PF08069.12 CCF41636.1 - 1.7e-30 104.8 0.1 2.9e-30 104.1 0.1 1.4 1 0 0 1 1 1 1 Ribosomal S13/S15 N-terminal domain Ribosomal_S15 PF00312.22 CCF41636.1 - 1.4e-15 57.3 0.1 2.2e-15 56.6 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S15 PAX PF00292.18 CCF41636.1 - 0.027 14.4 0.2 0.066 13.1 0.1 1.7 2 0 0 2 2 2 0 'Paired box' domain HOIP-UBA PF16678.5 CCF41636.1 - 0.068 13.2 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 HOIP UBA domain pair RRM_1 PF00076.22 CCF41637.1 - 8.3e-34 115.2 0.5 5.2e-14 51.8 0.0 3.9 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CCF41637.1 - 1.7e-06 27.7 0.1 0.12 12.2 0.0 3.4 3 0 0 3 3 3 2 Occluded RNA-recognition motif TcpA PF05946.12 CCF41637.1 - 0.069 13.3 0.8 1.2 9.2 0.0 2.4 2 1 0 2 2 2 0 Toxin-coregulated pilus subunit TcpA Nup35_RRM_2 PF14605.6 CCF41637.1 - 0.15 12.1 0.0 3.2 7.8 0.0 2.3 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif DUF5536 PF17688.1 CCF41638.1 - 0.11 12.4 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5536) PARM PF17061.5 CCF41638.1 - 1.1 9.4 0.0 1.1 9.4 0.0 2.7 3 0 0 3 3 3 0 PARM Peptidase_C15 PF01470.17 CCF41639.1 - 7e-05 23.1 0.0 7.7e-05 23.0 0.0 1.1 1 0 0 1 1 1 1 Pyroglutamyl peptidase Fungal_trans PF04082.18 CCF41640.1 - 7.5e-10 38.3 0.0 1.6e-09 37.2 0.0 1.5 1 1 0 1 1 1 1 Fungal specific transcription factor domain HTH_Tnp_Tc5 PF03221.16 CCF41642.1 - 4.3e-05 23.5 3.6 0.0015 18.5 0.0 3.9 3 2 1 4 4 4 1 Tc5 transposase DNA-binding domain Fasciclin PF02469.22 CCF41643.1 - 1.1e-41 142.0 0.0 5.7e-26 91.2 0.0 2.2 2 0 0 2 2 2 2 Fasciclin domain Glyoxalase_4 PF13669.6 CCF41644.1 - 0.15 12.4 0.0 0.25 11.7 0.0 1.4 1 0 0 1 1 1 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily MFS_1 PF07690.16 CCF41645.1 - 6e-30 104.3 42.4 4.9e-29 101.4 40.8 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily DUF4191 PF13829.6 CCF41645.1 - 5.2 6.4 8.3 1.7 8.0 0.4 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4191) BAR_2 PF10455.9 CCF41647.1 - 1.8e-59 201.3 0.0 2.6e-59 200.7 0.0 1.2 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR PF03114.18 CCF41647.1 - 3.2e-23 82.6 1.0 9e-22 77.9 1.1 2.1 1 1 0 1 1 1 1 BAR domain BAR_3 PF16746.5 CCF41647.1 - 0.0017 18.1 0.2 0.017 14.9 0.0 2.4 2 1 0 2 2 2 1 BAR domain of APPL family DUF1993 PF09351.10 CCF41647.1 - 0.079 13.1 0.4 0.27 11.4 0.4 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1993) YdjC PF04794.12 CCF41647.1 - 0.08 12.9 1.0 0.12 12.3 0.8 1.6 1 1 0 1 1 1 0 YdjC-like protein DUF488 PF04343.13 CCF41647.1 - 0.099 13.2 0.1 0.61 10.7 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function, DUF488 ETC_C1_NDUFA5 PF04716.14 CCF41648.1 - 5.5e-25 87.0 8.5 6e-25 86.8 0.3 2.8 4 0 0 4 4 4 2 ETC complex I subunit conserved region RNA_pol_I_TF PF04090.12 CCF41649.1 - 0.00096 18.7 0.0 0.009 15.5 0.0 2.0 2 0 0 2 2 2 1 RNA polymerase I specific initiation factor TPR_6 PF13174.6 CCF41649.1 - 0.37 11.5 3.0 14 6.6 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat WD40 PF00400.32 CCF41650.1 - 5.8e-12 45.9 21.0 1.7e-05 25.5 1.0 6.0 7 0 0 7 7 7 4 WD domain, G-beta repeat Fungal_trans_2 PF11951.8 CCF41652.1 - 0.00047 19.1 3.5 0.00064 18.6 2.8 1.5 2 0 0 2 2 2 1 Fungal specific transcription factor domain Glyco_hydro_17 PF00332.18 CCF41654.1 - 0.003 17.2 0.3 0.003 17.2 0.3 1.6 2 0 0 2 2 2 1 Glycosyl hydrolases family 17 Fungal_trans_2 PF11951.8 CCF41655.1 - 1.1e-11 44.3 0.0 1.2e-11 44.1 0.0 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain DHDPS PF00701.22 CCF41656.1 - 1.4e-43 148.7 0.0 1.8e-43 148.4 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family Amdase PF17645.1 CCF41656.1 - 0.084 12.5 0.1 0.2 11.2 0.0 1.5 2 0 0 2 2 2 0 Arylmalonate decarboxylase HTH_Tnp_Tc5 PF03221.16 CCF41657.1 - 2e-12 47.0 0.2 7.4e-12 45.1 0.0 2.0 3 0 0 3 3 3 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 CCF41657.1 - 3.2e-09 36.4 0.1 5.4e-09 35.7 0.1 1.4 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_23 PF13384.6 CCF41657.1 - 0.0029 17.4 0.4 0.011 15.5 0.1 2.1 2 0 0 2 2 2 1 Homeodomain-like domain CENP-B_N PF04218.13 CCF41657.1 - 0.016 14.8 0.0 0.03 14.0 0.0 1.4 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HTH_28 PF13518.6 CCF41657.1 - 0.071 13.2 0.7 0.23 11.6 0.0 2.2 3 0 0 3 3 3 0 Helix-turn-helix domain HTH_8 PF02954.19 CCF41657.1 - 0.15 11.9 0.1 0.65 9.8 0.0 2.0 1 1 1 2 2 2 0 Bacterial regulatory protein, Fis family PS-DH PF14765.6 CCF41658.1 - 5.7e-23 81.6 0.0 9.4e-23 80.9 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Methyltransf_12 PF08242.12 CCF41658.1 - 2e-18 67.0 0.0 5.8e-18 65.5 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain ADH_zinc_N PF00107.26 CCF41658.1 - 9.6e-17 61.2 0.2 9.4e-16 58.0 0.1 2.6 3 0 0 3 3 3 1 Zinc-binding dehydrogenase Methyltransf_25 PF13649.6 CCF41658.1 - 1.7e-11 44.7 0.0 9.6e-11 42.3 0.0 2.4 3 1 0 3 3 3 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF41658.1 - 3.4e-08 33.5 0.0 6e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain ADH_N PF08240.12 CCF41658.1 - 2.3e-07 30.7 0.1 7.8e-07 29.0 0.0 1.9 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain Methyltransf_11 PF08241.12 CCF41658.1 - 2.3e-07 31.4 0.0 6.4e-07 29.9 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF41658.1 - 3.4e-07 30.2 0.0 1.6e-06 28.0 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain ADH_zinc_N_2 PF13602.6 CCF41658.1 - 8.4e-07 30.1 0.0 4.2e-06 27.8 0.0 2.2 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Ubie_methyltran PF01209.18 CCF41658.1 - 0.0018 17.7 0.0 0.0038 16.6 0.0 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Mg_trans_NIPA PF05653.14 CCF41659.1 - 1.9e-17 63.3 11.1 3.4e-17 62.5 11.1 1.3 1 1 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 CCF41659.1 - 1.2e-05 25.5 13.2 0.00017 21.8 0.3 2.6 2 0 0 2 2 2 2 EamA-like transporter family PUNUT PF16913.5 CCF41659.1 - 0.011 15.0 12.2 0.041 13.1 10.8 2.3 1 1 1 2 2 2 0 Purine nucleobase transmembrane transport COX4_pro_2 PF07835.12 CCF41659.1 - 0.04 14.0 1.9 0.12 12.5 0.2 2.6 2 0 0 2 2 2 0 Bacterial aa3 type cytochrome c oxidase subunit IV Neurensin PF14927.6 CCF41659.1 - 0.08 12.6 3.3 0.73 9.5 0.2 3.1 3 0 0 3 3 3 0 Neurensin Cellulase PF00150.18 CCF41661.1 - 1e-48 166.2 0.0 1.3e-48 165.8 0.0 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) LrgB PF04172.16 CCF41663.1 - 1.1e-58 198.3 5.7 1.5e-58 197.9 5.7 1.1 1 0 0 1 1 1 1 LrgB-like family RuBisCO_small PF00101.20 CCF41664.1 - 0.053 13.5 0.4 0.065 13.2 0.4 1.1 1 0 0 1 1 1 0 Ribulose bisphosphate carboxylase, small chain NmrA PF05368.13 CCF41665.1 - 1.4e-12 47.7 0.7 1.5e-12 47.6 0.7 1.0 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CCF41665.1 - 5.8e-08 32.8 0.9 6.7e-08 32.6 0.9 1.0 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CCF41665.1 - 5.1e-07 29.4 0.1 5.9e-07 29.2 0.1 1.0 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CCF41665.1 - 7.6e-05 21.9 0.0 9e-05 21.6 0.0 1.0 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family KR PF08659.10 CCF41665.1 - 0.0003 20.8 0.3 0.00035 20.5 0.3 1.1 1 0 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.18 CCF41665.1 - 0.0036 17.5 0.1 0.0041 17.4 0.1 1.0 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 CCF41665.1 - 0.0089 16.1 0.2 0.0093 16.0 0.2 1.1 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase GDP_Man_Dehyd PF16363.5 CCF41665.1 - 0.019 14.3 0.0 0.022 14.2 0.0 1.0 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase F420_oxidored PF03807.17 CCF41665.1 - 0.035 14.7 0.1 0.04 14.5 0.1 1.1 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Semialdhyde_dh PF01118.24 CCF41665.1 - 0.071 13.5 0.1 0.079 13.4 0.1 1.1 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Staph_opine_DH PF10100.9 CCF41665.1 - 0.1 11.2 0.2 0.11 11.1 0.2 1.0 1 0 0 1 1 1 0 Staphylopine dehydrogenase DUF4265 PF14085.6 CCF41665.1 - 0.11 12.5 0.0 0.11 12.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4265) MDM10 PF12519.8 CCF41667.1 - 6.5e-172 572.6 0.0 7.4e-172 572.4 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial distribution and morphology protein 10 Porin_3 PF01459.22 CCF41667.1 - 0.0012 18.4 0.0 1.3 8.5 0.0 2.5 2 0 0 2 2 2 2 Eukaryotic porin zf-C2H2 PF00096.26 CCF41669.1 - 1.8e-05 24.9 18.3 0.56 10.8 1.2 4.7 4 0 0 4 4 4 4 Zinc finger, C2H2 type TT_ORF2 PF02957.15 CCF41669.1 - 0.014 16.3 2.3 0.037 15.0 2.3 1.7 1 0 0 1 1 1 0 TT viral ORF2 zf-C2H2_4 PF13894.6 CCF41669.1 - 0.034 15.0 20.6 0.39 11.7 0.8 5.0 4 1 0 4 4 4 0 C2H2-type zinc finger ROS_MUCR PF05443.11 CCF41669.1 - 0.08 13.0 0.7 3.1 7.9 0.1 3.1 3 0 0 3 3 3 0 ROS/MUCR transcriptional regulator protein zf-TAZ PF02135.16 CCF41669.1 - 0.22 12.0 2.7 0.54 10.8 0.8 2.2 2 0 0 2 2 2 0 TAZ zinc finger zf-C2HE PF16278.5 CCF41669.1 - 2 8.9 4.6 15 6.1 1.1 2.8 2 0 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger SH3_1 PF00018.28 CCF41670.1 - 2.9e-19 68.4 4.3 2.9e-12 46.0 0.5 2.5 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.6 CCF41670.1 - 4.2e-18 64.9 5.2 1e-13 50.9 0.5 2.5 2 0 0 2 2 2 2 Variant SH3 domain Cofilin_ADF PF00241.20 CCF41670.1 - 8.3e-15 54.7 0.0 1.7e-14 53.7 0.0 1.5 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein SH3_2 PF07653.17 CCF41670.1 - 1.8e-08 34.0 0.2 3.8e-07 29.7 0.0 2.7 3 0 0 3 3 3 1 Variant SH3 domain DUF543 PF04418.12 CCF41670.1 - 1.2 9.1 3.4 3.2 7.8 3.4 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF543) NADH_u_ox_C PF12853.7 CCF41672.1 - 6.2e-26 90.2 0.0 8e-26 89.9 0.0 1.1 1 0 0 1 1 1 1 C-terminal of NADH-ubiquinone oxidoreductase 21 kDa subunit Glyco_hydro_12 PF01670.16 CCF41673.1 - 2.4e-15 57.1 5.7 1.5e-14 54.5 5.7 2.0 1 1 0 1 1 1 1 Glycosyl hydrolase family 12 Mucin PF01456.17 CCF41673.1 - 0.021 14.8 12.3 0.038 14.0 12.3 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein SSP160 PF06933.11 CCF41673.1 - 0.64 8.1 8.7 0.92 7.6 8.7 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DNA_pol_B PF00136.21 CCF41675.1 - 1.1e-115 387.0 0.1 1.6e-115 386.5 0.1 1.3 1 0 0 1 1 1 1 DNA polymerase family B zf-DNA_Pol PF08996.10 CCF41675.1 - 5.3e-54 182.8 0.9 9.5e-54 182.0 0.9 1.4 1 0 0 1 1 1 1 DNA Polymerase alpha zinc finger DNA_pol_B_exo1 PF03104.19 CCF41675.1 - 1.5e-36 126.3 0.0 3.9e-36 124.9 0.0 1.7 2 0 0 2 2 2 1 DNA polymerase family B, exonuclease domain DNA_pol_B_2 PF03175.13 CCF41675.1 - 0.011 14.6 0.0 0.025 13.5 0.0 1.5 1 0 0 1 1 1 0 DNA polymerase type B, organellar and viral Fungal_trans PF04082.18 CCF41679.1 - 6.2e-13 48.4 0.0 1.2e-12 47.4 0.0 1.5 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF41679.1 - 8.4e-06 25.8 7.7 1.6e-05 24.9 7.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain IRK_N PF08466.10 CCF41682.1 - 0.058 13.6 0.2 0.83 9.9 0.1 2.1 2 0 0 2 2 2 0 Inward rectifier potassium channel N-terminal Proteasom_Rpn13 PF04683.13 CCF41683.1 - 2.9e-25 88.6 0.0 4.6e-25 88.0 0.0 1.3 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor RPN13_C PF16550.5 CCF41683.1 - 2.5e-10 40.5 1.0 1.3e-09 38.3 1.0 2.0 1 1 0 1 1 1 1 UCH-binding domain L27_2 PF09045.10 CCF41683.1 - 0.016 15.1 0.1 0.035 14.1 0.1 1.5 1 0 0 1 1 1 0 L27_2 EF1_GNE PF00736.19 CCF41684.1 - 5.1e-31 106.7 0.6 8e-31 106.1 0.6 1.3 1 0 0 1 1 1 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.9 CCF41684.1 - 2.2e-14 53.6 9.6 2.2e-14 53.6 9.6 2.3 2 0 0 2 2 2 1 Eukaryotic elongation factor 1 beta central acidic region GST_C_3 PF14497.6 CCF41684.1 - 0.00011 22.3 0.3 0.0011 19.1 0.0 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 CCF41684.1 - 0.00027 21.1 1.2 0.0011 19.2 0.0 2.6 3 1 0 3 3 3 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CCF41684.1 - 0.059 13.4 0.3 0.78 9.8 0.3 2.3 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain ATP-synt_E PF05680.12 CCF41684.1 - 0.2 12.0 1.9 0.42 11.0 1.9 1.6 1 0 0 1 1 1 0 ATP synthase E chain DNA_pol3_a_NII PF11490.8 CCF41684.1 - 5.8 6.8 8.1 4 7.3 0.1 2.2 2 0 0 2 2 2 0 DNA polymerase III polC-type N-terminus II Sld5 PF05916.11 CCF41685.1 - 2.6e-12 47.1 0.0 3.6e-12 46.7 0.0 1.2 1 0 0 1 1 1 1 GINS complex protein Sulfate_transp PF00916.20 CCF41686.1 - 3.1e-54 184.2 10.2 4.7e-54 183.6 10.2 1.2 1 0 0 1 1 1 1 Sulfate permease family cNMP_binding PF00027.29 CCF41686.1 - 2.3e-16 59.6 0.0 5e-16 58.6 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain STAS PF01740.21 CCF41686.1 - 1.3e-10 41.0 0.0 2.3e-10 40.2 0.0 1.4 1 0 0 1 1 1 1 STAS domain adh_short_C2 PF13561.6 CCF41687.1 - 9.7e-49 166.0 0.2 1.1e-48 165.8 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF41687.1 - 7.1e-48 162.7 0.1 8.7e-48 162.4 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF41687.1 - 1.1e-13 51.4 0.2 1.6e-13 51.0 0.2 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF41687.1 - 4e-05 23.2 0.1 7.4e-05 22.3 0.1 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CCF41687.1 - 5.9e-05 22.6 0.1 8.6e-05 22.1 0.1 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 CCF41687.1 - 0.00081 18.6 0.1 0.0011 18.1 0.1 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain 3HCDH_N PF02737.18 CCF41687.1 - 0.0013 18.7 0.1 0.0019 18.1 0.1 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Urocanase PF01175.18 CCF41687.1 - 0.0052 16.5 0.1 0.0071 16.0 0.1 1.3 1 0 0 1 1 1 1 Urocanase Rossmann-like domain 3Beta_HSD PF01073.19 CCF41687.1 - 0.0054 15.8 0.2 0.007 15.4 0.2 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 CCF41687.1 - 0.013 14.6 0.1 0.029 13.5 0.0 1.5 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein NmrA PF05368.13 CCF41687.1 - 0.02 14.4 0.3 0.029 13.9 0.3 1.2 1 0 0 1 1 1 0 NmrA-like family Methyltransf_25 PF13649.6 CCF41687.1 - 0.031 15.0 0.1 0.061 14.0 0.1 1.5 1 0 0 1 1 1 0 Methyltransferase domain NAD_binding_10 PF13460.6 CCF41687.1 - 0.031 14.2 0.4 0.049 13.5 0.4 1.3 1 0 0 1 1 1 0 NAD(P)H-binding THF_DHG_CYH_C PF02882.19 CCF41687.1 - 0.037 13.4 0.0 0.064 12.6 0.0 1.4 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain TrkA_N PF02254.18 CCF41687.1 - 0.04 14.2 0.1 0.064 13.5 0.1 1.3 1 0 0 1 1 1 0 TrkA-N domain F420_oxidored PF03807.17 CCF41687.1 - 0.041 14.5 0.1 0.25 12.0 0.1 2.0 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent NAD_binding_7 PF13241.6 CCF41687.1 - 0.05 14.0 0.1 0.09 13.2 0.1 1.3 1 0 0 1 1 1 0 Putative NAD(P)-binding AdoHcyase_NAD PF00670.21 CCF41687.1 - 0.065 13.3 0.3 0.12 12.5 0.3 1.3 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 CCF41687.1 - 0.075 12.4 0.2 0.21 10.9 0.1 1.8 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Methyltransf_12 PF08242.12 CCF41687.1 - 0.097 13.4 0.1 0.16 12.7 0.1 1.4 1 0 0 1 1 1 0 Methyltransferase domain Hydrophobin_2 PF06766.11 CCF41688.1 - 3.8e-15 55.6 9.7 3.8e-15 55.6 8.8 1.5 1 1 0 1 1 1 1 Fungal hydrophobin MerB PF03243.15 CCF41688.1 - 0.026 14.6 1.9 0.033 14.3 1.9 1.2 1 0 0 1 1 1 0 Alkylmercury lyase PMD PF10536.9 CCF41688.1 - 0.11 11.6 0.0 0.13 11.3 0.0 1.1 1 0 0 1 1 1 0 Plant mobile domain adh_short PF00106.25 CCF41689.1 - 8.2e-30 103.7 0.0 1.1e-29 103.3 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF41689.1 - 2.3e-23 83.0 0.0 3.4e-23 82.4 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF41689.1 - 4e-16 59.4 0.0 5.7e-16 58.9 0.0 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF41689.1 - 4.2e-05 23.1 0.2 0.00017 21.1 0.2 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family PAC2 PF09754.9 CCF41689.1 - 0.00092 19.3 0.0 0.0071 16.4 0.0 2.0 2 0 0 2 2 2 1 PAC2 family GDP_Man_Dehyd PF16363.5 CCF41689.1 - 0.0083 15.6 1.1 0.13 11.6 1.1 2.5 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase ST7 PF04184.12 CCF41689.1 - 0.023 13.2 0.0 0.035 12.6 0.0 1.2 1 0 0 1 1 1 0 ST7 protein Polysacc_synt_2 PF02719.15 CCF41689.1 - 0.055 12.6 0.0 0.068 12.3 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein MMS1_N PF10433.9 CCF41690.1 - 2e-116 389.5 0.0 2.8e-116 389.1 0.0 1.2 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 CCF41690.1 - 2.1e-28 99.6 0.0 1.1e-25 90.7 0.0 3.2 2 1 1 3 3 3 3 CPSF A subunit region O-antigen_lig PF13425.6 CCF41692.1 - 1.9e-05 23.7 0.1 0.011 14.6 0.0 2.2 2 0 0 2 2 2 2 O-antigen ligase like membrane protein CrgA PF06781.12 CCF41692.1 - 0.002 18.1 0.1 1.7 8.8 0.0 3.3 3 1 0 3 3 3 1 Cell division protein CrgA Phage_holin_3_6 PF07332.11 CCF41692.1 - 0.013 15.5 8.9 0.072 13.1 0.0 3.1 3 0 0 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III Chordopox_A13L PF05961.11 CCF41692.1 - 0.019 15.2 0.1 0.47 10.7 0.0 2.9 3 0 0 3 3 3 0 Chordopoxvirus A13L protein DUF4366 PF14283.6 CCF41692.1 - 0.029 14.4 0.1 7.1 6.7 0.0 2.7 2 2 0 2 2 2 0 Domain of unknown function (DUF4366) DUF5305 PF17231.2 CCF41692.1 - 0.062 12.7 2.0 3.4 7.0 0.1 3.3 2 1 2 4 4 4 0 Family of unknown function (DUF5305) Otopetrin PF03189.13 CCF41692.1 - 0.22 10.3 1.5 16 4.1 0.0 2.7 1 1 1 2 2 2 0 Otopetrin DUF2207 PF09972.9 CCF41692.1 - 0.72 8.6 6.3 1.7 7.3 0.1 3.0 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) DUF2569 PF10754.9 CCF41692.1 - 1.2 9.6 11.7 3.8 8.0 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2569) LapA_dom PF06305.11 CCF41692.1 - 2.5 8.0 5.6 15 5.5 0.0 3.5 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain EphA2_TM PF14575.6 CCF41692.1 - 3.5 8.6 4.6 33 5.5 0.0 3.6 3 1 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain PGAP1 PF07819.13 CCF41693.1 - 0.00033 20.5 0.0 0.00047 19.9 0.0 1.4 1 1 0 1 1 1 1 PGAP1-like protein DUF676 PF05057.14 CCF41693.1 - 0.00036 20.1 0.0 0.00049 19.7 0.0 1.1 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_6 PF12697.7 CCF41693.1 - 0.00081 20.0 0.0 0.00084 20.0 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family LIDHydrolase PF10230.9 CCF41693.1 - 0.017 14.7 0.0 0.018 14.6 0.0 1.1 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Hydrolase_4 PF12146.8 CCF41693.1 - 0.021 14.1 0.0 0.051 12.8 0.0 1.7 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Palm_thioest PF02089.15 CCF41693.1 - 0.03 14.2 0.0 0.033 14.0 0.0 1.1 1 0 0 1 1 1 0 Palmitoyl protein thioesterase DUF915 PF06028.11 CCF41693.1 - 0.05 12.9 0.0 5.7 6.2 0.0 2.3 2 1 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) DUF900 PF05990.12 CCF41693.1 - 0.068 12.7 0.0 0.29 10.6 0.0 1.9 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF900) Lipase_3 PF01764.25 CCF41693.1 - 0.11 12.3 0.0 0.14 12.0 0.0 1.1 1 0 0 1 1 1 0 Lipase (class 3) SAM_2 PF07647.17 CCF41694.1 - 1.4e-16 60.3 0.0 2.7e-16 59.4 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 CCF41694.1 - 1.5e-15 57.4 0.0 2.6e-15 56.6 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RA PF00788.23 CCF41694.1 - 7.7e-11 42.5 0.0 1.9e-10 41.3 0.0 1.6 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain SAM_4 PF18017.1 CCF41694.1 - 0.00038 20.4 0.0 0.00067 19.6 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) CCDC66 PF15236.6 CCF41694.1 - 0.29 11.0 2.2 2.3 8.0 0.1 2.2 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 66 Myb_DNA-binding PF00249.31 CCF41695.1 - 9.3e-08 32.1 0.6 3e-07 30.5 0.0 2.1 2 1 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CCF41695.1 - 2.3e-05 24.6 0.1 5.7e-05 23.3 0.0 1.7 1 1 0 1 1 1 1 Myb-like DNA-binding domain Rap1_C PF11626.8 CCF41695.1 - 0.0085 16.2 0.0 0.011 15.7 0.0 1.3 1 0 0 1 1 1 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain Kelch_4 PF13418.6 CCF41697.1 - 7.8e-17 61.0 0.2 1.8e-05 24.6 0.0 4.7 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_3 PF13415.6 CCF41697.1 - 5.8e-15 55.2 9.2 8.7e-09 35.5 0.0 6.6 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_5 PF13854.6 CCF41697.1 - 2e-14 53.2 2.2 4e-07 29.9 0.1 4.0 3 0 0 3 3 3 2 Kelch motif Kelch_1 PF01344.25 CCF41697.1 - 5.3e-14 51.5 0.1 0.00052 19.5 0.0 4.6 4 0 0 4 4 4 3 Kelch motif Kelch_6 PF13964.6 CCF41697.1 - 2.3e-13 49.9 4.5 0.0015 18.8 1.1 4.7 3 1 1 4 4 4 3 Kelch motif Kelch_2 PF07646.15 CCF41697.1 - 8.6e-08 31.9 0.4 0.00025 20.9 0.0 4.7 5 1 0 5 5 5 1 Kelch motif BTB PF00651.31 CCF41697.1 - 0.044 14.0 0.0 0.25 11.6 0.0 2.1 2 0 0 2 2 2 0 BTB/POZ domain ADH_N PF08240.12 CCF41699.1 - 1.9e-25 88.8 7.2 2.3e-25 88.6 7.2 1.1 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain US6 PF17616.2 CCF41702.1 - 0.3 11.0 1.0 18 5.2 0.0 2.1 2 0 0 2 2 2 0 Viral unique short region 6 Totivirus_coat PF05518.11 CCF41702.1 - 5 5.0 6.3 6.3 4.7 6.3 1.3 1 0 0 1 1 1 0 Totivirus coat protein AMP-binding PF00501.28 CCF41703.1 - 5e-88 295.5 0.0 5.8e-88 295.3 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CCF41703.1 - 2.7e-18 66.7 0.0 6.9e-18 65.4 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain GH3 PF03321.13 CCF41703.1 - 0.00029 19.8 0.0 0.0016 17.4 0.0 1.9 2 0 0 2 2 2 1 GH3 auxin-responsive promoter RTX_C PF08339.10 CCF41703.1 - 0.033 14.3 0.0 0.069 13.2 0.0 1.5 1 0 0 1 1 1 0 RTX C-terminal domain Acetyltransf_10 PF13673.7 CCF41705.1 - 1.2e-09 38.2 0.0 2.1e-09 37.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CCF41705.1 - 3e-08 34.0 0.0 5e-08 33.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CCF41705.1 - 1.9e-07 31.3 0.0 4e-07 30.3 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 CCF41705.1 - 0.0022 18.0 0.0 0.0038 17.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CCF41705.1 - 0.0032 17.4 0.0 0.0056 16.6 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 CCF41705.1 - 0.004 17.2 0.0 0.0093 16.1 0.0 1.5 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase TED_complement PF07678.14 CCF41706.1 - 0.13 11.2 0.1 0.19 10.7 0.1 1.2 1 0 0 1 1 1 0 A-macroglobulin TED domain Clat_adaptor_s PF01217.20 CCF41707.1 - 3.9e-56 188.9 1.5 4.3e-56 188.8 1.5 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain CMV_1a PF12467.8 CCF41708.1 - 0.094 13.1 0.4 0.22 11.9 0.4 1.5 1 0 0 1 1 1 0 Cucumber mosaic virus 1a protein family Mfa1 PF17445.2 CCF41708.1 - 0.37 10.8 1.9 0.93 9.6 1.9 1.6 1 0 0 1 1 1 0 Mating factor A1 GDPD PF03009.17 CCF41711.1 - 0.26 11.0 0.0 0.37 10.5 0.0 1.1 1 0 0 1 1 1 0 Glycerophosphoryl diester phosphodiesterase family LSDAT_prok PF18171.1 CCF41712.1 - 0.17 11.1 0.0 0.24 10.6 0.0 1.2 1 0 0 1 1 1 0 SLOG in TRPM, prokaryote p450 PF00067.22 CCF41713.1 - 1.2e-08 34.2 0.0 1.4e-08 33.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 ADK PF00406.22 CCF41714.1 - 6.8e-26 91.2 0.1 9.2e-26 90.8 0.1 1.2 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 CCF41714.1 - 9.5e-11 42.3 0.1 1.3e-10 41.8 0.1 1.2 1 0 0 1 1 1 1 AAA domain Trimer_CC PF08954.11 CCF41714.1 - 0.019 14.5 0.0 0.031 13.9 0.0 1.3 1 0 0 1 1 1 0 Trimerisation motif BLOC1_2 PF10046.9 CCF41714.1 - 0.062 13.6 0.3 0.1 12.9 0.3 1.4 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Laminin_II PF06009.12 CCF41714.1 - 0.064 13.3 0.1 0.098 12.7 0.1 1.4 1 0 0 1 1 1 0 Laminin Domain II Dynactin_p22 PF07426.11 CCF41714.1 - 0.14 12.1 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 Dynactin subunit p22 HCR PF07111.12 CCF41714.1 - 0.17 10.0 0.3 0.17 9.9 0.3 1.0 1 0 0 1 1 1 0 Alpha helical coiled-coil rod protein (HCR) MitMem_reg PF13012.6 CCF41715.1 - 1.7e-37 128.2 0.1 5.3e-37 126.7 0.1 1.8 2 0 0 2 2 2 1 Maintenance of mitochondrial structure and function JAB PF01398.21 CCF41715.1 - 1.5e-30 105.6 0.2 3.5e-30 104.4 0.0 1.7 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease tRNA_bind_2 PF13725.6 CCF41715.1 - 0.024 14.4 5.5 0.034 13.8 5.5 1.2 1 0 0 1 1 1 0 Possible tRNA binding domain Connexin PF00029.19 CCF41715.1 - 0.74 9.5 3.3 1 9.0 3.3 1.2 1 0 0 1 1 1 0 Connexin LNS2 PF08235.13 CCF41716.1 - 4.7e-93 310.8 0.0 6.1e-93 310.5 0.0 1.1 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Acid_phosphat_B PF03767.14 CCF41716.1 - 0.0011 18.6 0.0 0.097 12.2 0.0 2.3 2 0 0 2 2 2 2 HAD superfamily, subfamily IIIB (Acid phosphatase) PI3K_1B_p101 PF10486.9 CCF41716.1 - 5.3 4.7 9.3 7.6 4.2 9.3 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit TFIID-31kDa PF02291.15 CCF41717.1 - 9.1e-43 145.2 0.0 1.4e-42 144.6 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Spt20 PF12090.8 CCF41717.1 - 0.00082 19.0 16.5 0.0011 18.6 16.5 1.3 1 0 0 1 1 1 1 Spt20 family Presenilin PF01080.17 CCF41717.1 - 0.17 10.6 7.1 0.22 10.3 7.1 1.2 1 0 0 1 1 1 0 Presenilin PAT1 PF09770.9 CCF41717.1 - 0.46 8.7 12.7 0.52 8.5 12.7 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF3464 PF11947.8 CCF41717.1 - 1.2 8.9 5.6 2.1 8.1 5.6 1.4 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Ndc1_Nup PF09531.10 CCF41717.1 - 1.3 7.6 8.7 1.5 7.4 8.7 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Pex14_N PF04695.13 CCF41717.1 - 1.5 9.4 25.6 2.4 8.8 25.6 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region SOG2 PF10428.9 CCF41717.1 - 3.6 6.7 17.1 4 6.5 17.1 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein GREB1 PF15782.5 CCF41717.1 - 5.3 4.0 9.2 5.8 3.9 9.2 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer CCDC53 PF10152.9 CCF41717.1 - 9.8 6.6 15.3 20 5.6 15.3 1.5 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex ketoacyl-synt PF00109.26 CCF41720.1 - 2e-67 227.4 0.0 2.4e-67 227.2 0.0 1.1 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 CCF41720.1 - 8.9e-14 51.5 0.0 1.6e-13 50.7 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.23 CCF41720.1 - 0.0034 16.8 0.0 0.0049 16.3 0.0 1.1 1 0 0 1 1 1 1 Thiolase, N-terminal domain ACP_syn_III PF08545.10 CCF41720.1 - 0.034 14.0 0.2 0.063 13.1 0.2 1.4 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III KRAB PF01352.27 CCF41720.1 - 0.51 10.0 1.4 1.4 8.6 0.2 2.2 2 0 0 2 2 2 0 KRAB box Peptidase_S8 PF00082.22 CCF41721.1 - 1.5e-15 57.3 0.6 2.1e-15 56.8 0.6 1.2 1 0 0 1 1 1 1 Subtilase family Rotamase_3 PF13616.6 CCF41722.1 - 1.6e-18 67.3 0.1 3.2e-18 66.3 0.1 1.5 1 1 0 1 1 1 1 PPIC-type PPIASE domain Rotamase PF00639.21 CCF41722.1 - 4.7e-17 62.7 0.1 7.4e-17 62.1 0.1 1.4 1 1 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.6 CCF41722.1 - 3.8e-05 24.5 0.8 4.6e-05 24.2 0.1 1.5 1 1 1 2 2 2 1 PPIC-type PPIASE domain Ribosomal_L7Ae PF01248.26 CCF41723.1 - 4.4e-28 96.9 1.0 5.7e-28 96.5 1.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PELOTA_1 PF15608.6 CCF41723.1 - 0.09 12.7 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 PELOTA RNA binding domain Ribosomal_S8 PF00410.19 CCF41724.1 - 6.5e-22 77.8 0.0 8.6e-22 77.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S8 SBP_bac_6 PF13343.6 CCF41727.1 - 0.0077 15.7 0.3 0.01 15.2 0.3 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein MFS_1 PF07690.16 CCF41729.1 - 7.2e-13 48.2 19.0 9.1e-13 47.8 19.0 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Git3 PF11710.8 CCF41731.1 - 5e-21 75.4 7.6 1e-20 74.4 7.6 1.4 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 7tm_1 PF00001.21 CCF41731.1 - 2.1e-11 43.7 0.4 2.4e-11 43.5 0.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) GPR_Gpa2_C PF11970.8 CCF41731.1 - 0.0016 18.5 0.3 0.0053 16.8 0.3 1.8 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 C-term Dicty_CAR PF05462.11 CCF41731.1 - 0.14 11.3 10.9 0.016 14.4 6.5 1.6 2 0 0 2 2 2 0 Slime mold cyclic AMP receptor SdpI PF13630.6 CCF41732.1 - 0.0025 17.9 2.7 0.0025 17.9 2.7 1.6 2 0 0 2 2 2 1 SdpI/YhfL protein family GMC_oxred_C PF05199.13 CCF41733.1 - 1.5e-21 77.5 0.0 1.7e-21 77.2 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase Zn_Tnp_IS1595 PF12760.7 CCF41733.1 - 0.07 13.1 0.1 0.12 12.4 0.1 1.4 1 0 0 1 1 1 0 Transposase zinc-ribbon domain Acyl-CoA_dh_1 PF00441.24 CCF41734.1 - 1.5e-27 96.6 0.2 2.6e-27 95.8 0.2 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 CCF41734.1 - 4.5e-20 71.7 0.0 7.9e-20 70.9 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 CCF41734.1 - 1e-13 51.9 0.0 1.9e-13 51.1 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 CCF41734.1 - 1.4e-12 48.0 0.2 2.4e-12 47.3 0.2 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain DUF5301 PF17225.3 CCF41735.1 - 0.47 10.9 4.4 2.9 8.4 0.7 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF5300) NAD_binding_6 PF08030.12 CCF41735.1 - 2.8 8.0 6.7 0.61 10.2 1.8 1.9 2 0 0 2 2 2 0 Ferric reductase NAD binding domain Abhydrolase_1 PF00561.20 CCF41736.1 - 1.7e-11 44.3 0.0 1e-10 41.7 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CCF41736.1 - 1.6e-07 30.8 0.0 1.2e-06 28.0 0.0 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Cohesin_load PF10345.9 CCF41737.1 - 6.2e-135 451.0 0.1 9e-135 450.4 0.1 1.1 1 0 0 1 1 1 1 Cohesin loading factor Pet127 PF08634.10 CCF41737.1 - 3.2e-15 56.3 0.0 7.4e-15 55.1 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial protein Pet127 Pil1 PF13805.6 CCF41739.1 - 2.4e-112 374.7 7.9 3.4e-112 374.2 7.9 1.2 1 0 0 1 1 1 1 Eisosome component PIL1 Ribophorin_I PF04597.14 CCF41740.1 - 1.3e-150 502.4 3.4 1.5e-150 502.2 3.4 1.0 1 0 0 1 1 1 1 Ribophorin I Hexokinase_2 PF03727.16 CCF41741.1 - 7.5e-84 280.9 0.0 1.2e-83 280.2 0.0 1.3 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 CCF41741.1 - 2.7e-73 246.1 0.0 8.5e-73 244.5 0.0 1.7 2 0 0 2 2 2 1 Hexokinase Ank_2 PF12796.7 CCF41742.1 - 0.02 15.5 0.0 0.89 10.2 0.0 2.3 1 1 1 2 2 2 0 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CCF41742.1 - 0.18 12.4 0.1 4.9 7.9 0.0 2.4 2 0 0 2 2 2 0 Ankyrin repeats (many copies) VTC PF09359.10 CCF41743.1 - 2.7e-99 332.0 0.0 4.4e-99 331.3 0.0 1.3 1 0 0 1 1 1 1 VTC domain DUF202 PF02656.15 CCF41743.1 - 3.9e-14 52.8 2.4 6.9e-14 52.0 2.4 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF202) SPX PF03105.19 CCF41743.1 - 4.9e-12 46.5 11.6 2.2e-05 24.6 0.2 4.2 2 1 1 4 4 4 2 SPX domain FixQ PF05545.11 CCF41743.1 - 0.033 14.2 1.5 0.069 13.1 1.5 1.5 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ PMP22_Claudin PF00822.20 CCF41743.1 - 0.21 11.5 1.0 0.35 10.7 1.0 1.3 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin family Cys_Met_Meta_PP PF01053.20 CCF41744.1 - 4.4e-25 88.0 0.0 1.6e-24 86.2 0.0 1.7 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme LysM PF01476.20 CCF41745.1 - 1.5e-16 60.2 0.0 2.6e-06 27.4 0.0 3.2 3 0 0 3 3 3 2 LysM domain NLPC_P60 PF00877.19 CCF41745.1 - 0.0042 17.1 0.8 0.2 11.7 0.0 2.9 3 0 0 3 3 3 1 NlpC/P60 family LysM PF01476.20 CCF41746.1 - 1.5e-07 31.3 0.0 8.4e-07 29.0 0.0 2.0 2 0 0 2 2 2 1 LysM domain RCDG1 PF15725.5 CCF41746.1 - 0.073 13.5 0.1 0.34 11.3 0.0 1.9 2 0 0 2 2 2 0 Renal cancer differentiation gene 1 protein Glyco_hydro_18 PF00704.28 CCF41747.1 - 5.1e-18 65.8 0.0 6.1e-18 65.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 NPV_P10 PF05531.12 CCF41748.1 - 0.04 14.4 6.5 0.26 11.7 0.2 3.0 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF720 PF05302.11 CCF41748.1 - 1.4 8.8 13.2 0.46 10.3 2.4 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF720) Jnk-SapK_ap_N PF09744.9 CCF41749.1 - 0.0033 17.7 46.1 0.0069 16.6 10.7 3.9 1 1 4 5 5 5 3 JNK_SAPK-associated protein-1 Fib_alpha PF08702.10 CCF41749.1 - 0.0071 16.5 4.5 0.0071 16.5 4.5 4.0 1 1 3 4 4 4 1 Fibrinogen alpha/beta chain family KASH_CCD PF14662.6 CCF41749.1 - 0.0093 15.8 39.9 0.017 15.0 24.0 3.2 1 1 2 3 3 3 2 Coiled-coil region of CCDC155 or KASH HAUS-augmin3 PF14932.6 CCF41749.1 - 0.014 15.0 41.1 0.51 9.9 4.0 3.3 1 1 2 3 3 3 0 HAUS augmin-like complex subunit 3 Leu_zip PF15294.6 CCF41749.1 - 0.014 14.9 41.9 0.047 13.2 13.6 3.2 1 1 2 3 3 3 0 Leucine zipper CENP-F_leu_zip PF10473.9 CCF41749.1 - 0.052 13.6 41.5 0.12 12.4 0.2 4.4 2 2 2 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CALCOCO1 PF07888.11 CCF41749.1 - 0.15 10.9 47.3 0.87 8.4 30.7 3.0 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like APG6_N PF17675.1 CCF41749.1 - 0.35 11.4 47.1 2.2 8.8 9.0 4.5 1 1 3 4 4 4 0 Apg6 coiled-coil region HAP1_N PF04849.13 CCF41749.1 - 0.54 9.4 37.9 0.023 13.9 21.2 2.3 1 1 1 2 2 2 0 HAP1 N-terminal conserved region DUF1664 PF07889.12 CCF41749.1 - 0.82 9.7 22.5 0.45 10.6 2.0 4.4 1 1 2 4 4 4 0 Protein of unknown function (DUF1664) ADIP PF11559.8 CCF41749.1 - 1.2 9.2 47.6 2 8.5 4.4 5.0 1 1 4 5 5 5 0 Afadin- and alpha -actinin-Binding HOOK PF05622.12 CCF41749.1 - 2.9 6.0 47.8 0.14 10.3 19.6 3.1 1 1 2 3 3 3 0 HOOK protein GIT_CC PF16559.5 CCF41749.1 - 3.3 7.6 20.4 11 6.0 1.9 4.6 3 1 1 4 4 4 0 GIT coiled-coil Rho guanine nucleotide exchange factor Laminin_I PF06008.14 CCF41749.1 - 3.5 7.2 38.6 0.046 13.4 8.4 3.8 1 1 3 4 4 4 0 Laminin Domain I UPF0242 PF06785.11 CCF41749.1 - 3.5 7.7 37.9 1.6 8.8 9.3 3.4 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus Lebercilin PF15619.6 CCF41749.1 - 3.6 7.2 48.7 7.8 6.1 13.7 4.1 1 1 2 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease Fibritin_C PF07921.12 CCF41749.1 - 3.8 7.7 6.4 0.93 9.7 0.7 2.7 1 1 0 2 2 2 0 Fibritin C-terminal region Fez1 PF06818.15 CCF41749.1 - 4.6 7.6 44.9 2.9 8.3 19.0 3.0 1 1 1 2 2 1 0 Fez1 Shugoshin_N PF07558.11 CCF41749.1 - 9.1 6.2 17.7 0.38 10.6 2.9 3.8 4 2 0 4 4 3 0 Shugoshin N-terminal coiled-coil region Peptidase_S41 PF03572.18 CCF41750.1 - 4.3e-10 39.4 0.0 7.9e-10 38.5 0.0 1.4 1 0 0 1 1 1 1 Peptidase family S41 DUF5086 PF16985.5 CCF41750.1 - 0.076 12.9 0.0 0.19 11.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5086) DUF3446 PF11928.8 CCF41750.1 - 0.29 11.5 9.7 0.2 12.0 1.3 2.5 2 0 0 2 2 2 0 Early growth response N-terminal domain GH131_N PF18271.1 CCF41751.1 - 1.4e-43 149.4 0.0 1.6e-43 149.2 0.0 1.0 1 0 0 1 1 1 1 Glycoside hydrolase 131 catalytic N-terminal domain Glyco_hydro_47 PF01532.20 CCF41752.1 - 1.2e-34 120.0 0.1 1.3e-34 119.9 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Ku_N PF03731.15 CCF41754.1 - 0.12 12.1 0.1 0.12 12.1 0.1 1.0 1 0 0 1 1 1 0 Ku70/Ku80 N-terminal alpha/beta domain ADH_N PF08240.12 CCF41755.1 - 3e-29 101.1 4.6 4.8e-29 100.4 3.1 2.0 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCF41755.1 - 1.2e-14 54.4 0.0 1.8e-14 53.8 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 CCF41755.1 - 2.5e-10 40.2 0.0 3.8e-10 39.6 0.0 1.2 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 CCF41755.1 - 1.8e-08 35.5 0.0 3.2e-08 34.7 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase FAD_binding_3 PF01494.19 CCF41755.1 - 0.022 14.0 0.1 0.035 13.3 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain fn3 PF00041.21 CCF41755.1 - 0.16 12.3 0.0 20 5.6 0.0 2.3 2 0 0 2 2 2 0 Fibronectin type III domain Staph_opine_DH PF10100.9 CCF41755.1 - 0.25 9.9 0.0 0.36 9.4 0.0 1.2 1 0 0 1 1 1 0 Staphylopine dehydrogenase DUF3712 PF12505.8 CCF41756.1 - 2.1e-11 44.1 0.0 5.1e-11 42.9 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3712) HECT PF00632.25 CCF41757.1 - 9.9e-76 255.1 0.0 1.4e-75 254.7 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Mito_carr PF00153.27 CCF41758.1 - 3.1e-19 68.7 0.6 8.8e-16 57.6 0.1 2.3 2 1 0 2 2 2 2 Mitochondrial carrier protein DUF3021 PF11457.8 CCF41759.1 - 0.0035 17.7 5.5 0.0035 17.7 5.5 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF3021) Atthog PF18800.1 CCF41759.1 - 0.013 15.4 1.5 0.022 14.6 1.5 1.3 1 0 0 1 1 1 0 Attenuator of Hedgehog DUF1154 PF06631.11 CCF41759.1 - 0.071 13.1 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1154) SURF4 PF02077.15 CCF41759.1 - 0.072 12.7 1.3 0.1 12.1 1.3 1.1 1 0 0 1 1 1 0 SURF4 family SUR7 PF06687.12 CCF41759.1 - 0.24 11.0 6.7 0.37 10.4 6.7 1.2 1 0 0 1 1 1 0 SUR7/PalI family OAD_gamma PF04277.13 CCF41759.1 - 0.3 11.7 1.5 0.66 10.6 1.5 1.5 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Phage_holin_3_6 PF07332.11 CCF41759.1 - 0.37 10.8 3.3 0.84 9.7 3.3 1.5 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III FtsX PF02687.21 CCF41759.1 - 6.2 7.4 9.9 3.2 8.3 6.8 2.1 2 1 0 2 2 2 0 FtsX-like permease family HOK_GEF PF01848.16 CCF41761.1 - 0.043 13.2 1.6 0.1 12.0 1.6 1.5 1 0 0 1 1 1 0 Hok/gef family UQ_con PF00179.26 CCF41762.1 - 2.5e-08 33.7 0.0 4.4e-08 32.9 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme F-box PF00646.33 CCF41762.1 - 0.00018 21.3 0.1 0.0005 19.9 0.1 1.8 1 0 0 1 1 1 1 F-box domain TRCF PF03461.15 CCF41762.1 - 0.031 14.7 0.0 0.085 13.2 0.0 1.7 1 0 0 1 1 1 0 TRCF domain DIT1_PvcA PF05141.12 CCF41764.1 - 2.7e-86 289.5 0.0 3.3e-86 289.2 0.0 1.1 1 0 0 1 1 1 1 Pyoverdine/dityrosine biosynthesis protein DIT1_PvcA PF05141.12 CCF41765.1 - 5.9e-18 65.3 0.0 7.2e-18 65.0 0.0 1.1 1 0 0 1 1 1 1 Pyoverdine/dityrosine biosynthesis protein Fungal_trans PF04082.18 CCF41766.1 - 3.4e-26 91.9 0.0 6e-26 91.1 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF41766.1 - 1.9e-09 37.5 10.9 3e-09 36.9 10.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS18 PF17352.2 CCF41766.1 - 0.0012 19.2 8.4 0.0012 19.2 8.4 2.3 2 0 0 2 2 2 1 Male Flower Specific protein 18 IF-2B PF01008.17 CCF41767.1 - 0.054 12.7 0.1 0.057 12.6 0.1 1.0 1 0 0 1 1 1 0 Initiation factor 2 subunit family WD40 PF00400.32 CCF41768.1 - 6.8e-31 105.8 19.3 2.7e-05 24.8 0.0 7.4 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF41768.1 - 3.9e-12 46.3 0.1 0.21 11.9 0.1 5.6 4 1 2 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain HIRA_B PF09453.10 CCF41768.1 - 4.5e-10 39.1 0.4 1.2e-09 37.8 0.4 1.8 1 0 0 1 1 1 1 HIRA B motif PD40 PF07676.12 CCF41768.1 - 7.9e-05 22.5 0.8 2.8 8.0 0.3 4.4 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 CCF41768.1 - 9.1e-05 21.6 3.4 0.82 8.6 0.0 4.2 3 2 2 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein IKI3 PF04762.12 CCF41768.1 - 0.0046 15.0 0.1 0.035 12.1 0.0 2.2 3 0 0 3 3 3 1 IKI3 family PepX_C PF08530.10 CCF41770.1 - 8.7e-44 150.1 1.3 1.5e-43 149.4 1.3 1.2 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain Peptidase_S15 PF02129.18 CCF41770.1 - 1e-36 126.9 0.1 1.6e-36 126.3 0.1 1.2 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Hydrolase_4 PF12146.8 CCF41770.1 - 0.0062 15.8 0.0 0.0099 15.2 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Sugar_tr PF00083.24 CCF41771.1 - 9.9e-46 156.5 17.7 2.7e-45 155.1 17.7 1.6 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF41771.1 - 2.3e-17 63.0 26.8 4.8e-17 61.9 26.2 1.9 2 1 0 2 2 2 1 Major Facilitator Superfamily Peptidase_M6 PF05547.11 CCF41773.1 - 1.1e-07 30.6 0.2 0.0014 17.1 0.8 2.1 2 0 0 2 2 2 2 Immune inhibitor A peptidase M6 DIOX_N PF14226.6 CCF41774.1 - 1.4e-31 109.7 0.0 2.2e-31 109.0 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 CCF41774.1 - 6.1e-13 49.1 0.0 1.2e-12 48.2 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Peroxidase_2 PF01328.17 CCF41775.1 - 8.9e-45 153.5 0.0 1.1e-44 153.2 0.0 1.1 1 0 0 1 1 1 1 Peroxidase, family 2 MFS_1 PF07690.16 CCF41776.1 - 2.2e-21 76.2 20.0 2.8e-21 75.8 20.0 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Wzz PF02706.15 CCF41776.1 - 0.27 11.6 1.5 21 5.5 0.0 2.8 3 0 0 3 3 3 0 Chain length determinant protein AAA_lid_11 PF18198.1 CCF41779.1 - 7.4e-15 55.1 0.0 8.5e-15 55.0 0.0 1.0 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain MARVEL PF01284.23 CCF41783.1 - 0.64 10.0 3.3 3.7 7.6 3.3 2.0 1 1 0 1 1 1 0 Membrane-associating domain Fungal_trans PF04082.18 CCF41784.1 - 1.7e-14 53.5 0.2 2.5e-14 53.0 0.2 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF41784.1 - 2.4e-07 30.7 9.3 3.9e-07 30.1 9.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4110 PF13422.6 CCF41785.1 - 1.2e-31 108.6 1.3 1.2e-31 108.6 1.3 2.3 2 1 0 2 2 2 1 Domain of unknown function (DUF4110) YL1 PF05764.13 CCF41785.1 - 0.0001 22.6 12.7 0.00012 22.4 12.7 1.2 1 0 0 1 1 1 1 YL1 nuclear protein CDC45 PF02724.14 CCF41785.1 - 0.0034 15.8 12.3 0.0036 15.7 12.3 1.1 1 0 0 1 1 1 1 CDC45-like protein PTPRCAP PF15713.5 CCF41785.1 - 0.022 15.1 15.9 0.022 15.1 15.9 1.7 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated Kelch_5 PF13854.6 CCF41785.1 - 0.031 14.3 0.0 0.057 13.4 0.0 1.5 1 0 0 1 1 1 0 Kelch motif Nop14 PF04147.12 CCF41785.1 - 0.072 11.3 18.7 0.086 11.0 18.7 1.1 1 0 0 1 1 1 0 Nop14-like family PI3K_1B_p101 PF10486.9 CCF41785.1 - 0.12 10.1 9.5 0.16 9.8 9.5 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit BUD22 PF09073.10 CCF41785.1 - 0.15 11.4 16.4 0.16 11.3 16.4 1.2 1 0 0 1 1 1 0 BUD22 Kelch_4 PF13418.6 CCF41785.1 - 0.24 11.4 0.5 1.6 8.8 0.1 2.3 2 0 0 2 2 2 0 Galactose oxidase, central domain DUF2457 PF10446.9 CCF41785.1 - 1.8 7.6 26.1 2.7 7.1 26.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DUF913 PF06025.12 CCF41785.1 - 1.9 7.4 4.0 2.3 7.1 4.0 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF4611 PF15387.6 CCF41785.1 - 2 8.7 20.6 0.09 13.0 12.9 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) Sporozoite_P67 PF05642.11 CCF41785.1 - 2.5 6.1 14.8 3.4 5.6 14.8 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen GCIP PF13324.6 CCF41785.1 - 2.5 7.6 13.6 4.1 6.9 13.6 1.4 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting Presenilin PF01080.17 CCF41785.1 - 5.5 5.7 4.2 6.2 5.5 4.2 1.1 1 0 0 1 1 1 0 Presenilin DUF2722 PF10846.8 CCF41785.1 - 5.8 5.7 12.1 7.8 5.3 12.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) WLM PF08325.10 CCF41786.1 - 7e-29 101.3 0.5 2.1e-28 99.7 0.1 1.9 2 1 0 2 2 2 1 WLM domain DUF45 PF01863.17 CCF41786.1 - 1.7e-07 31.5 0.2 1.7e-07 31.5 0.2 2.2 3 0 0 3 3 3 1 Protein of unknown function DUF45 DZR PF12773.7 CCF41786.1 - 1.8 8.6 6.8 4.9 7.3 6.8 1.8 1 0 0 1 1 1 0 Double zinc ribbon Dcc1 PF09724.9 CCF41787.1 - 2.9e-09 36.7 0.1 3.3e-09 36.5 0.1 1.1 1 0 0 1 1 1 1 Sister chromatid cohesion protein Dcc1 IBR PF01485.21 CCF41788.1 - 0.008 16.4 27.3 0.081 13.2 4.5 3.1 3 0 0 3 3 3 2 IBR domain, a half RING-finger domain Rad4 PF03835.15 CCF41789.1 - 9.4e-32 109.7 0.0 4e-31 107.7 0.0 2.1 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain BHD_3 PF10405.9 CCF41789.1 - 1.9e-26 92.3 0.4 3.9e-26 91.3 0.4 1.6 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BHD_1 PF10403.9 CCF41789.1 - 1.3e-17 63.3 0.1 3.2e-17 62.1 0.1 1.7 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 BHD_2 PF10404.9 CCF41789.1 - 1.1e-16 61.5 0.6 1.1e-16 61.5 0.6 6.8 6 1 0 6 6 6 2 Rad4 beta-hairpin domain 2 Transglut_core PF01841.19 CCF41789.1 - 0.0025 18.3 0.0 0.0098 16.3 0.0 2.1 1 1 0 1 1 1 1 Transglutaminase-like superfamily zf-AN1 PF01428.16 CCF41790.1 - 1.4e-24 86.0 23.9 4.2e-12 46.0 5.9 2.2 2 0 0 2 2 2 2 AN1-like Zinc finger IBR PF01485.21 CCF41790.1 - 0.018 15.2 4.1 0.018 15.2 4.1 2.7 2 1 0 2 2 2 0 IBR domain, a half RING-finger domain Transp_Tc5_C PF04236.15 CCF41790.1 - 1.2 9.6 15.2 1.2 9.6 6.3 2.3 2 0 0 2 2 2 0 Tc5 transposase C-terminal domain MTP18 PF10558.9 CCF41791.1 - 5.7e-73 244.5 0.0 6.6e-73 244.3 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial 18 KDa protein (MTP18) DHC_N1 PF08385.12 CCF41792.1 - 2.7e-102 343.3 8.9 3.8e-102 342.8 8.9 1.2 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 1 DUF5362 PF17319.2 CCF41792.1 - 0.16 11.8 0.1 0.4 10.6 0.1 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5362) MIP PF00230.20 CCF41794.1 - 4.6e-50 170.4 19.2 5.7e-50 170.1 19.2 1.1 1 0 0 1 1 1 1 Major intrinsic protein bZIP_1 PF00170.21 CCF41795.1 - 1.5e-09 37.8 15.8 1.5e-09 37.8 15.8 2.4 2 0 0 2 2 2 1 bZIP transcription factor bZIP_Maf PF03131.17 CCF41795.1 - 8.5e-08 32.6 13.8 2.4e-07 31.2 13.8 1.7 1 0 0 1 1 1 1 bZIP Maf transcription factor bZIP_2 PF07716.15 CCF41795.1 - 0.0089 16.1 21.2 0.0092 16.1 15.9 3.0 2 1 1 3 3 3 1 Basic region leucine zipper UPF0242 PF06785.11 CCF41795.1 - 0.017 15.2 20.4 0.032 14.3 20.4 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Sec5 PF15469.6 CCF41795.1 - 0.092 12.5 6.7 0.19 11.5 6.7 1.4 1 0 0 1 1 1 0 Exocyst complex component Sec5 DUF2205 PF10224.9 CCF41795.1 - 0.14 12.2 10.5 0.12 12.4 8.5 2.0 1 1 1 2 2 2 0 Short coiled-coil protein Fmp27_WPPW PF10359.9 CCF41795.1 - 0.47 9.3 12.5 0.69 8.7 12.5 1.2 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain FapA PF03961.13 CCF41795.1 - 1.3 7.6 10.6 1.8 7.0 10.6 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF4441 PF14536.6 CCF41795.1 - 1.7 8.8 6.1 6 7.1 6.1 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4441) 5_nucleotid PF05761.14 CCF41795.1 - 7.9 5.2 10.1 12 4.7 10.1 1.3 1 0 0 1 1 1 0 5' nucleotidase family V_ATPase_I PF01496.19 CCF41795.1 - 8.2 4.2 10.3 12 3.7 10.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Exonuc_VII_L PF02601.15 CCF41795.1 - 10 5.6 11.8 18 4.8 11.8 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Glycos_transf_1 PF00534.20 CCF41796.1 - 2.5e-34 118.3 0.0 4e-34 117.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 CCF41796.1 - 2.2e-28 99.4 0.0 3.6e-28 98.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 CCF41796.1 - 1.4e-16 61.3 1.0 1.4e-16 61.3 1.0 1.9 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_transf_4 PF13439.6 CCF41796.1 - 1.3e-12 48.0 0.1 2e-11 44.2 0.2 2.3 2 0 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_trans_1_2 PF13524.6 CCF41796.1 - 6.3e-10 39.3 0.0 1.3e-09 38.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Cutinase PF01083.22 CCF41797.1 - 4e-28 98.6 3.3 5.6e-28 98.1 3.3 1.2 1 0 0 1 1 1 1 Cutinase PE-PPE PF08237.11 CCF41797.1 - 0.00091 18.8 0.1 0.0013 18.4 0.1 1.2 1 0 0 1 1 1 1 PE-PPE domain Lipase_3 PF01764.25 CCF41797.1 - 0.086 12.7 0.1 0.12 12.2 0.1 1.2 1 0 0 1 1 1 0 Lipase (class 3) Palm_thioest PF02089.15 CCF41797.1 - 0.1 12.4 0.3 0.095 12.5 0.3 1.1 1 0 0 1 1 1 0 Palmitoyl protein thioesterase MFS_1 PF07690.16 CCF41798.1 - 6.9e-42 143.6 46.3 2.2e-35 122.3 28.9 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2417 PF10329.9 CCF41798.1 - 0.22 10.9 2.2 0.46 9.9 2.2 1.5 1 0 0 1 1 1 0 Region of unknown function (DUF2417) zf-RING_6 PF14835.6 CCF41798.1 - 0.47 10.3 2.4 1.9 8.4 0.2 2.4 2 0 0 2 2 2 0 zf-RING of BARD1-type protein Xan_ur_permease PF00860.20 CCF41800.1 - 2.4e-07 29.8 2.7 3.2e-07 29.4 2.7 1.1 1 0 0 1 1 1 1 Permease family NESP55 PF06390.12 CCF41802.1 - 0.25 10.9 6.2 0.49 9.9 6.2 1.5 1 0 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) WD40 PF00400.32 CCF41804.1 - 1.5e-06 28.8 18.5 0.00018 22.2 1.2 6.1 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF41804.1 - 0.00092 19.5 0.1 0.41 11.0 0.1 3.7 2 2 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain DUF4379 PF14311.6 CCF41804.1 - 0.036 14.4 10.3 1.2 9.6 1.3 3.0 2 0 0 2 2 2 0 Probable Zinc-ribbon domain zinc_ribbon_16 PF17034.5 CCF41804.1 - 0.53 10.5 6.3 1.3 9.2 6.3 1.6 1 0 0 1 1 1 0 Zinc-ribbon like family Zn_ribbon_17 PF17120.5 CCF41804.1 - 1.9 8.1 17.5 0.083 12.5 9.8 2.3 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type zinc_ribbon_4 PF13717.6 CCF41804.1 - 5 7.1 6.2 0.39 10.7 0.7 2.0 2 0 0 2 2 2 0 zinc-ribbon domain Atg14 PF10186.9 CCF41805.1 - 1.6e-12 47.2 5.2 6.9e-12 45.1 5.2 1.8 1 1 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 VPS38 PF17649.1 CCF41805.1 - 1.5e-11 43.8 0.1 6.5e-06 25.3 0.0 3.4 3 0 0 3 3 3 2 Vacuolar protein sorting 38 FapA PF03961.13 CCF41805.1 - 0.038 12.6 2.0 0.062 11.9 2.0 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF4522 PF15022.6 CCF41805.1 - 0.08 13.2 0.3 0.16 12.3 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4522) DUF4407 PF14362.6 CCF41805.1 - 9.8 5.4 8.4 17 4.6 8.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Tom37 PF10568.9 CCF41807.1 - 1.3e-33 116.0 0.0 1.8e-33 115.5 0.0 1.2 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_C_6 PF17171.4 CCF41807.1 - 4.2e-07 29.7 1.2 3.4e-06 26.7 0.0 3.0 3 1 0 3 3 3 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 CCF41807.1 - 4.4e-05 24.1 0.0 9.3e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C_2 PF13410.6 CCF41807.1 - 0.0036 17.3 0.2 0.01 15.8 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain TFR_dimer PF04253.15 CCF41808.1 - 5.8e-28 97.4 0.0 9.8e-28 96.7 0.0 1.4 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 CCF41808.1 - 1.7e-19 70.3 0.0 2.9e-19 69.6 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 CCF41808.1 - 5.7e-09 35.9 0.6 3.1e-08 33.5 0.1 2.2 2 0 0 2 2 2 1 PA domain Lipin_mid PF16876.5 CCF41809.1 - 0.088 13.0 0.0 0.095 12.9 0.0 1.0 1 0 0 1 1 1 0 Lipin/Ned1/Smp2 multi-domain protein middle domain BCS1_N PF08740.11 CCF41810.1 - 8.4e-44 149.8 0.0 1.1e-43 149.4 0.0 1.1 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 CCF41810.1 - 6.9e-05 23.3 0.0 0.00013 22.4 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 CCF41810.1 - 0.00076 19.1 0.0 0.02 14.5 0.0 2.4 2 1 1 3 3 3 1 AAA domain AAA_7 PF12775.7 CCF41810.1 - 0.0012 18.4 0.0 0.0021 17.6 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_5 PF07728.14 CCF41810.1 - 0.0023 17.9 0.0 0.0051 16.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 CCF41810.1 - 0.014 15.6 0.0 0.05 13.8 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 CCF41810.1 - 0.019 14.7 0.0 0.041 13.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 CCF41810.1 - 0.024 15.2 0.0 0.047 14.2 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_22 PF13401.6 CCF41810.1 - 0.037 14.3 0.0 0.07 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain Alpha_GJ PF03229.13 CCF41810.1 - 0.04 14.5 7.4 0.072 13.6 4.2 2.3 2 0 0 2 2 2 0 Alphavirus glycoprotein J AAA_16 PF13191.6 CCF41810.1 - 0.042 14.2 0.0 0.096 13.1 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain PPV_E1_C PF00519.17 CCF41810.1 - 0.056 12.3 0.0 0.096 11.5 0.0 1.3 1 0 0 1 1 1 0 Papillomavirus helicase AAA_18 PF13238.6 CCF41810.1 - 0.07 13.7 0.0 0.14 12.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 CCF41810.1 - 0.091 13.2 0.0 0.17 12.3 0.0 1.4 1 0 0 1 1 1 0 RNA helicase RsgA_GTPase PF03193.16 CCF41810.1 - 0.092 12.7 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase MMR_HSR1 PF01926.23 CCF41810.1 - 0.1 12.7 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase AFOR_C PF01314.18 CCF41810.1 - 0.12 11.3 0.0 0.18 10.8 0.0 1.1 1 0 0 1 1 1 0 Aldehyde ferredoxin oxidoreductase, domains 2 & 3 ATP_bind_1 PF03029.17 CCF41810.1 - 0.15 11.8 0.0 0.22 11.3 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein ATPase PF06745.13 CCF41810.1 - 0.18 11.1 0.0 0.29 10.5 0.0 1.3 1 0 0 1 1 1 0 KaiC AAA_17 PF13207.6 CCF41810.1 - 0.19 12.2 0.0 0.32 11.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 CCF41810.1 - 0.21 11.3 0.0 0.35 10.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain Epimerase PF01370.21 CCF41812.1 - 2.9e-14 53.1 0.0 5.2e-14 52.3 0.0 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CCF41812.1 - 8e-12 44.7 0.0 1.2e-11 44.2 0.0 1.3 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 CCF41812.1 - 8.4e-11 41.5 0.1 2.5e-08 33.4 0.1 2.1 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 CCF41812.1 - 9e-11 42.0 0.2 1.3e-10 41.4 0.2 1.3 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 CCF41812.1 - 1e-07 31.7 0.0 1.5e-07 31.1 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NmrA PF05368.13 CCF41812.1 - 4.2e-07 29.8 0.4 1.4e-06 28.1 0.7 1.7 2 0 0 2 2 2 1 NmrA-like family Sacchrp_dh_NADP PF03435.18 CCF41812.1 - 0.00023 21.4 0.2 0.00054 20.2 0.1 1.6 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Polysacc_synt_2 PF02719.15 CCF41812.1 - 0.00026 20.2 0.1 0.00037 19.7 0.1 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.25 CCF41812.1 - 0.00072 19.1 0.3 0.0014 18.1 0.2 1.6 2 1 0 2 2 2 1 short chain dehydrogenase RmlD_sub_bind PF04321.17 CCF41812.1 - 0.0026 16.9 0.1 0.0037 16.4 0.1 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain KR PF08659.10 CCF41812.1 - 0.0048 16.8 0.5 0.053 13.4 0.5 2.1 1 1 0 1 1 1 1 KR domain Mon2_C PF16206.5 CCF41813.1 - 5.1e-19 67.9 8.2 1.3e-12 46.8 0.4 3.2 1 1 2 3 3 3 3 C-terminal region of Mon2 protein DUF1981 PF09324.10 CCF41813.1 - 5.9e-07 29.2 0.1 0.00037 20.3 0.0 3.0 2 0 0 2 2 2 2 Domain of unknown function (DUF1981) STAS_2 PF13466.6 CCF41813.1 - 9 6.7 9.7 5.4 7.4 0.3 3.9 3 1 0 3 3 3 0 STAS domain CDC37_M PF08565.11 CCF41814.1 - 6.5e-41 139.0 0.1 1.9e-40 137.4 0.0 1.8 2 0 0 2 2 2 1 Cdc37 Hsp90 binding domain CDC37_C PF08564.10 CCF41814.1 - 2.6e-32 110.9 0.7 2.6e-32 110.9 0.7 2.5 2 1 0 2 2 2 1 Cdc37 C terminal domain MgtE_N PF03448.17 CCF41814.1 - 0.21 12.2 2.0 0.78 10.4 0.1 2.7 3 0 0 3 3 3 0 MgtE intracellular N domain Sigma_reg_C PF13791.6 CCF41814.1 - 1.6 9.0 5.4 1.1 9.5 2.8 1.9 1 1 1 2 2 2 0 Sigma factor regulator C-terminal DUF3552 PF12072.8 CCF41814.1 - 2.2 7.7 10.6 0.19 11.1 5.3 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3552) Glyco_hydro_71 PF03659.14 CCF41815.1 - 5.6e-118 394.0 0.1 7.9e-118 393.5 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 71 Thioredoxin_7 PF13899.6 CCF41816.1 - 2.9e-18 65.8 0.0 6.4e-18 64.7 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like UBA_4 PF14555.6 CCF41816.1 - 2.6e-15 55.9 1.7 3.2e-15 55.6 0.5 1.9 2 0 0 2 2 2 1 UBA-like domain UBX PF00789.20 CCF41816.1 - 9.7e-08 32.1 0.0 1.8e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 UBX domain Thioredox_DsbH PF03190.15 CCF41816.1 - 0.0041 17.1 0.0 0.0082 16.1 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF255 CCDC50_N PF15295.6 CCF41816.1 - 0.48 10.6 4.4 1.1 9.5 4.4 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 50 N-terminus Serglycin PF04360.12 CCF41816.1 - 4.3 7.3 5.3 0.68 9.9 0.2 2.1 2 0 0 2 2 2 0 Serglycin DAO PF01266.24 CCF41818.1 - 1.7e-49 169.3 0.6 1.9e-49 169.1 0.6 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CCF41818.1 - 0.00025 21.2 1.0 0.0006 20.0 0.2 2.1 2 1 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 CCF41818.1 - 0.0031 17.5 0.2 0.039 13.9 0.1 2.2 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 CCF41818.1 - 0.0032 16.8 0.0 0.019 14.2 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CCF41818.1 - 0.013 14.7 0.0 0.022 14.0 0.0 1.2 1 0 0 1 1 1 0 Thi4 family Pyr_redox_3 PF13738.6 CCF41818.1 - 0.028 13.7 0.0 0.41 9.8 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 CCF41818.1 - 0.053 12.6 0.1 0.084 11.9 0.1 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein HI0933_like PF03486.14 CCF41818.1 - 0.12 11.0 0.0 1.7 7.2 0.0 2.0 2 0 0 2 2 2 0 HI0933-like protein Amino_oxidase PF01593.24 CCF41819.1 - 6e-65 220.3 0.0 7.6e-65 220.0 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CCF41819.1 - 1.6e-08 34.7 0.2 1.3e-07 31.8 0.0 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 CCF41819.1 - 0.00043 19.5 0.0 0.0007 18.8 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 CCF41819.1 - 0.00044 19.9 0.0 0.002 17.8 0.0 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 CCF41819.1 - 0.003 16.9 0.4 0.0053 16.0 0.4 1.4 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 CCF41819.1 - 0.012 14.4 0.0 0.02 13.6 0.0 1.4 1 0 0 1 1 1 0 HI0933-like protein Pyr_redox_2 PF07992.14 CCF41819.1 - 0.015 14.6 0.0 0.05 12.8 0.0 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CCF41819.1 - 0.081 12.2 0.2 0.15 11.3 0.2 1.3 1 0 0 1 1 1 0 Thi4 family Pyr_redox_3 PF13738.6 CCF41819.1 - 0.083 12.1 0.3 0.15 11.3 0.3 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.20 CCF41819.1 - 0.12 12.4 0.5 0.52 10.4 0.2 2.0 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Rhodanese PF00581.20 CCF41820.1 - 0.0035 17.8 0.0 0.0048 17.4 0.0 1.2 1 0 0 1 1 1 1 Rhodanese-like domain SLATT_fungal PF18142.1 CCF41821.1 - 4.1e-25 88.1 0.0 5.6e-25 87.7 0.0 1.2 1 0 0 1 1 1 1 SMODS and SLOG-associating 2TM effector domain MSA-2c PF12238.8 CCF41821.1 - 0.079 12.9 0.0 0.11 12.5 0.0 1.1 1 0 0 1 1 1 0 Merozoite surface antigen 2c TRM PF02005.16 CCF41822.1 - 8.6e-108 360.9 0.0 5.2e-94 315.5 0.0 2.1 2 0 0 2 2 2 2 N2,N2-dimethylguanosine tRNA methyltransferase BSP_II PF05432.11 CCF41822.1 - 1.5 8.4 18.2 0.57 9.8 3.9 2.2 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) DUF1744 PF08490.12 CCF41823.1 - 4.4e-153 509.6 0.0 5.7e-153 509.2 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1744) AAA_22 PF13401.6 CCF41825.1 - 0.07 13.4 0.0 0.075 13.3 0.0 1.1 1 0 0 1 1 1 0 AAA domain Aminotran_5 PF00266.19 CCF41826.1 - 3.3e-10 39.5 0.0 4.5e-10 39.0 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Abhydrolase_6 PF12697.7 CCF41827.1 - 3.1e-13 50.8 1.2 5.8e-12 46.7 1.2 2.1 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCF41827.1 - 1.1e-05 24.8 0.0 0.0086 15.4 0.0 2.4 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CCF41827.1 - 0.00035 20.3 0.0 0.00095 18.9 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold DUF3089 PF11288.8 CCF41827.1 - 0.017 14.7 0.0 0.03 13.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) Peptidase_S9 PF00326.21 CCF41827.1 - 0.026 14.0 0.0 9.6 5.6 0.0 3.5 3 1 0 4 4 4 0 Prolyl oligopeptidase family TAT_signal PF10518.9 CCF41827.1 - 0.99 9.4 4.8 1.8 8.5 4.8 1.5 1 0 0 1 1 1 0 TAT (twin-arginine translocation) pathway signal sequence AATase PF07247.12 CCF41828.1 - 6.3e-10 38.2 0.0 1.3e-09 37.2 0.0 1.4 2 0 0 2 2 2 1 Alcohol acetyltransferase DUF4748 PF15932.5 CCF41829.1 - 3.4e-27 94.0 0.7 4.5e-27 93.6 0.7 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4748) Rav1p_C PF12234.8 CCF41829.1 - 0.16 10.4 0.0 0.18 10.2 0.0 1.1 1 0 0 1 1 1 0 RAVE protein 1 C terminal UDPG_MGDP_dh PF00984.19 CCF41831.1 - 1.9e-29 101.7 0.0 3.7e-29 100.8 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_C PF03720.15 CCF41831.1 - 6.5e-21 74.7 0.0 7.1e-17 61.7 0.0 2.4 2 0 0 2 2 2 2 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain PNP_UDP_1 PF01048.20 CCF41832.1 - 0.0032 16.8 0.1 0.0036 16.6 0.1 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily FrhB_FdhB_C PF04432.13 CCF41832.1 - 0.23 11.3 0.0 0.23 11.3 0.0 1.1 1 0 0 1 1 1 0 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus Acetyltransf_3 PF13302.7 CCF41833.1 - 3.3e-11 44.0 0.0 4.8e-11 43.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CCF41833.1 - 0.048 13.9 0.0 0.068 13.4 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Glyco_hydro_43 PF04616.14 CCF41834.1 - 1.6e-65 221.3 0.0 2.1e-65 220.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 GH43_C2 PF17851.1 CCF41834.1 - 4.4e-08 33.1 0.0 7.3e-08 32.4 0.0 1.3 1 0 0 1 1 1 1 Beta xylosidase C-terminal Concanavalin A-like domain adh_short PF00106.25 CCF41835.1 - 1.6e-26 93.0 0.1 1.2e-21 77.1 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCF41835.1 - 3.4e-14 53.0 0.4 2.2e-12 47.0 0.4 2.1 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF41835.1 - 1.7e-10 41.1 0.1 2.9e-10 40.3 0.1 1.5 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF41835.1 - 1.1e-05 25.0 0.1 1.7e-05 24.4 0.1 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 CCF41835.1 - 0.0042 16.3 0.0 0.015 14.5 0.0 1.8 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein Sacchrp_dh_NADP PF03435.18 CCF41835.1 - 0.014 15.7 0.1 0.031 14.5 0.0 1.6 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Amidohydro_2 PF04909.14 CCF41835.1 - 0.029 14.2 0.8 0.16 11.7 0.8 2.4 1 1 0 1 1 1 0 Amidohydrolase Shikimate_DH PF01488.20 CCF41835.1 - 0.17 11.9 0.0 0.36 10.9 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Glyco_hydro_28 PF00295.17 CCF41836.1 - 3.9e-111 371.2 22.4 4.4e-111 371.0 22.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Helicase_C PF00271.31 CCF41837.1 - 8.2e-21 74.4 0.0 1.3e-20 73.8 0.0 1.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 CCF41837.1 - 0.00044 19.5 0.0 0.0015 17.8 0.0 1.8 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 Tyrosinase PF00264.20 CCF41838.1 - 9.5e-40 137.2 0.2 1.3e-39 136.8 0.2 1.1 1 0 0 1 1 1 1 Common central domain of tyrosinase HMG_box PF00505.19 CCF41838.1 - 0.17 12.3 0.1 0.31 11.5 0.1 1.3 1 0 0 1 1 1 0 HMG (high mobility group) box Fungal_trans PF04082.18 CCF41839.1 - 0.00015 20.9 0.0 0.00027 20.0 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 CCF41840.1 - 4.2 8.0 11.9 0.59 10.7 1.6 3.4 3 0 0 3 3 3 0 Zinc finger, C2H2 type ABC2_membrane PF01061.24 CCF41844.1 - 1.2e-43 149.0 17.7 1.9e-43 148.4 17.7 1.3 1 0 0 1 1 1 1 ABC-2 type transporter ABC_trans_N PF14510.6 CCF41844.1 - 1.3e-15 57.7 0.0 2.7e-15 56.7 0.0 1.5 1 0 0 1 1 1 1 ABC-transporter N-terminal PDR_CDR PF06422.12 CCF41844.1 - 8.5e-15 54.4 0.1 2.4e-14 53.0 0.1 1.8 1 0 0 1 1 1 1 CDR ABC transporter ABC_tran PF00005.27 CCF41844.1 - 5.2e-14 52.9 0.0 1.2e-13 51.8 0.0 1.6 2 0 0 2 2 2 1 ABC transporter AAA_16 PF13191.6 CCF41844.1 - 0.13 12.6 0.0 0.29 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain DUF2070 PF09843.9 CCF41844.1 - 2.5 6.3 8.8 3.6 5.8 8.8 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Presenilin PF01080.17 CCF41845.1 - 0.13 11.0 1.4 0.11 11.2 1.4 1.0 1 0 0 1 1 1 0 Presenilin Pex14_N PF04695.13 CCF41845.1 - 0.14 12.8 9.0 0.17 12.5 9.0 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Spt20 PF12090.8 CCF41845.1 - 0.17 11.5 18.6 0.19 11.3 18.6 1.2 1 0 0 1 1 1 0 Spt20 family Med3 PF11593.8 CCF41845.1 - 0.43 9.7 27.1 0.057 12.6 23.0 1.6 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal Menin PF05053.13 CCF41845.1 - 0.62 8.4 7.3 0.7 8.2 7.3 1.0 1 0 0 1 1 1 0 Menin TFIIA PF03153.13 CCF41845.1 - 1.7 8.6 16.5 1.7 8.6 16.5 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Androgen_recep PF02166.16 CCF41845.1 - 3.3 6.4 12.0 3.2 6.5 12.0 1.1 1 0 0 1 1 1 0 Androgen receptor ORC_WH_C PF18137.1 CCF41845.1 - 6.5 6.8 8.2 24 5.0 0.1 2.1 2 0 0 2 2 2 0 Origin recognition complex winged helix C-terminal LysM PF01476.20 CCF41846.1 - 0.034 14.2 0.0 0.069 13.2 0.0 1.5 1 0 0 1 1 1 0 LysM domain Arv1 PF04161.13 CCF41847.1 - 6.8e-80 268.2 0.7 8.3e-80 267.9 0.7 1.1 1 0 0 1 1 1 1 Arv1-like family ATP_synt_H PF05493.13 CCF41848.1 - 4.2e-24 84.8 1.7 4.7e-24 84.6 1.7 1.0 1 0 0 1 1 1 1 ATP synthase subunit H 7TM-7TMR_HD PF07698.11 CCF41848.1 - 0.012 15.4 0.2 0.013 15.3 0.2 1.0 1 0 0 1 1 1 0 7TM receptor with intracellular HD hydrolase DUF4131 PF13567.6 CCF41848.1 - 0.019 14.6 1.4 0.021 14.5 1.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) DUF2070 PF09843.9 CCF41848.1 - 0.065 11.5 0.1 0.07 11.4 0.1 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Flavi_NS4A PF01350.17 CCF41848.1 - 0.074 13.0 0.6 0.086 12.8 0.6 1.1 1 0 0 1 1 1 0 Flavivirus non-structural protein NS4A ARL6IP6 PF15062.6 CCF41848.1 - 0.12 12.5 0.2 0.16 12.1 0.1 1.3 1 1 0 1 1 1 0 Haemopoietic lineage transmembrane helix DUF1075 PF06388.11 CCF41848.1 - 0.2 11.7 0.0 0.28 11.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1075) NAD_binding_2 PF03446.15 CCF41849.1 - 1.4e-25 90.3 0.2 2.2e-25 89.7 0.2 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 CCF41849.1 - 5e-12 46.1 0.4 1.2e-09 38.5 0.0 2.2 2 0 0 2 2 2 2 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Shikimate_DH PF01488.20 CCF41849.1 - 7.4e-09 35.8 0.0 3.1e-08 33.8 0.0 1.9 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 CCF41849.1 - 2.6e-07 31.1 0.0 8.3e-07 29.5 0.0 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent TrkA_N PF02254.18 CCF41849.1 - 3.2e-06 27.4 0.1 7.4e-06 26.2 0.1 1.6 1 0 0 1 1 1 1 TrkA-N domain Sacchrp_dh_NADP PF03435.18 CCF41849.1 - 0.0037 17.5 0.1 0.0088 16.3 0.1 1.8 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_3 PF03447.16 CCF41849.1 - 0.0041 17.8 0.2 0.011 16.3 0.1 1.7 1 1 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain HTH_Tnp_Mu_2 PF09039.11 CCF41849.1 - 0.016 15.3 0.1 0.049 13.7 0.0 1.8 2 0 0 2 2 2 0 Mu DNA binding, I gamma subdomain NAT PF04768.13 CCF41850.1 - 3.8e-49 166.6 0.0 1.6e-48 164.5 0.0 1.8 2 0 0 2 2 2 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase Ribosomal_L3 PF00297.22 CCF41852.1 - 1.2e-29 103.5 0.2 1.3e-29 103.3 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 Cwf_Cwc_15 PF04889.12 CCF41853.1 - 0.14 11.9 12.4 0.18 11.5 12.4 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein TFIIE-A_C PF11521.8 CCF41853.1 - 0.31 11.4 20.6 0.39 11.0 5.6 2.3 1 1 0 2 2 2 0 C-terminal general transcription factor TFIIE alpha CDC27 PF09507.10 CCF41853.1 - 1.1 8.6 15.9 1.5 8.1 15.9 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 SWIRM-assoc_2 PF16496.5 CCF41853.1 - 1.4 7.7 8.0 1.8 7.4 8.0 1.1 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal MCM_bind PF09739.9 CCF41853.1 - 3.5 6.0 5.8 4 5.8 5.8 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor ORC6 PF05460.13 CCF41853.1 - 7.4 5.7 9.4 33 3.6 9.4 1.8 1 1 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Zn_clus PF00172.18 CCF41855.1 - 3.8e-05 23.7 12.0 6.4e-05 23.0 12.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_hydro_7 PF00840.20 CCF41856.1 - 4.9e-183 608.8 16.7 5.6e-183 608.6 16.7 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 7 Mob1_phocein PF03637.17 CCF41859.1 - 9.9e-43 146.1 0.0 2e-42 145.1 0.0 1.5 1 1 0 1 1 1 1 Mob1/phocein family Epimerase PF01370.21 CCF41861.1 - 1.2e-05 24.9 0.0 1.2e-05 24.9 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CCF41861.1 - 0.00025 20.6 0.0 0.00027 20.4 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NmrA PF05368.13 CCF41861.1 - 0.0026 17.4 0.0 0.0027 17.3 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family adh_short PF00106.25 CCF41861.1 - 0.0064 16.0 0.0 0.0069 15.9 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase Polysacc_synt_2 PF02719.15 CCF41861.1 - 0.017 14.3 0.0 0.017 14.3 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 CCF41861.1 - 0.019 14.9 0.0 0.022 14.6 0.0 1.1 1 0 0 1 1 1 0 NAD(P)H-binding 3Beta_HSD PF01073.19 CCF41861.1 - 0.058 12.4 0.0 0.063 12.3 0.0 1.1 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family PHD PF00628.29 CCF41864.1 - 0.00021 21.1 8.5 0.00037 20.3 8.5 1.4 1 0 0 1 1 1 1 PHD-finger TYA PF01021.19 CCF41864.1 - 0.13 12.6 0.0 0.13 12.6 0.0 2.9 3 0 0 3 3 3 0 TYA transposon protein CoA_transf_3 PF02515.17 CCF41865.1 - 8.9e-125 416.6 0.0 1e-124 416.4 0.0 1.0 1 0 0 1 1 1 1 CoA-transferase family III Sigma70_r4 PF04545.16 CCF41865.1 - 0.019 14.5 0.1 0.043 13.3 0.1 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 DUF3099 PF11298.8 CCF41866.1 - 0.76 10.0 3.5 0.56 10.4 1.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3099) CitMHS PF03600.16 CCF41867.1 - 9.2e-14 51.3 2.2 2e-13 50.2 2.2 1.5 1 0 0 1 1 1 1 Citrate transporter ArsB PF02040.15 CCF41867.1 - 2.9e-11 43.4 21.4 3.5e-08 33.2 8.4 2.1 2 0 0 2 2 2 2 Arsenical pump membrane protein zf-C2H2 PF00096.26 CCF41868.1 - 0.008 16.6 2.2 0.008 16.6 2.2 2.8 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-H2C2_5 PF13909.6 CCF41868.1 - 0.035 13.9 0.4 0.035 13.9 0.4 2.9 3 0 0 3 3 3 0 C2H2-type zinc-finger domain AMP-binding PF00501.28 CCF41869.1 - 2.9e-95 319.3 0.0 3.9e-95 318.9 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CCF41869.1 - 1.8e-11 44.9 1.2 4.6e-11 43.6 1.2 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain WRW PF10206.9 CCF41869.1 - 0.14 12.5 0.0 0.32 11.4 0.0 1.5 1 0 0 1 1 1 0 Mitochondrial F1F0-ATP synthase, subunit f GDP_Man_Dehyd PF16363.5 CCF41870.1 - 0.00089 18.8 0.0 0.0012 18.3 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase FSH1 PF03959.13 CCF41871.1 - 1.7e-29 103.1 0.0 2.1e-29 102.7 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_3 PF07859.13 CCF41871.1 - 0.0067 16.3 0.2 0.012 15.5 0.2 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 CCF41871.1 - 0.019 14.7 0.2 0.14 11.9 0.0 2.1 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase Pkinase PF00069.25 CCF41872.1 - 4.4e-70 236.1 0.0 6.1e-70 235.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF41872.1 - 9.8e-52 175.8 0.0 1.5e-51 175.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CCF41872.1 - 0.00067 18.5 0.0 0.0012 17.8 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 CCF41872.1 - 0.014 14.7 0.0 0.035 13.4 0.0 1.6 2 0 0 2 2 2 0 Kinase-like Pal1 PF08316.11 CCF41873.1 - 3.8e-44 150.8 1.0 8.3e-44 149.7 1.0 1.6 1 0 0 1 1 1 1 Pal1 cell morphology protein TMEM234 PF10639.9 CCF41874.1 - 2.7e-35 120.9 0.1 3.5e-35 120.6 0.1 1.1 1 0 0 1 1 1 1 Putative transmembrane family 234 EamA PF00892.20 CCF41874.1 - 0.0005 20.2 6.4 0.39 10.9 6.2 2.2 1 1 0 2 2 2 2 EamA-like transporter family PetM PF08041.11 CCF41874.1 - 8.5 6.1 8.2 1.4 8.6 2.6 2.5 2 0 0 2 2 2 0 PetM family of cytochrome b6f complex subunit 7 DUF2011 PF09428.10 CCF41875.1 - 0.041 14.1 0.0 0.79 10.0 0.0 2.2 1 1 1 2 2 2 0 Fungal protein of unknown function (DUF2011) DUF4249 PF14054.6 CCF41875.1 - 0.19 11.3 0.0 0.23 11.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4249) PCI PF01399.27 CCF41876.1 - 4.1e-18 65.8 0.3 1.3e-17 64.3 0.0 2.0 2 0 0 2 2 2 1 PCI domain TPR_2 PF07719.17 CCF41876.1 - 0.029 14.5 2.4 0.42 10.9 0.2 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 CCF41876.1 - 0.18 11.7 1.8 1.3 9.0 0.2 3.2 4 0 0 4 4 4 0 Tetratricopeptide repeat RPM2 PF08579.11 CCF41876.1 - 0.45 10.9 2.9 12 6.4 0.2 3.2 2 1 1 3 3 3 0 Mitochondrial ribonuclease P subunit (RPM2) CWC25 PF12542.8 CCF41877.1 - 2.6e-24 86.0 0.3 2.6e-24 86.0 0.3 2.4 2 1 1 3 3 3 1 Pre-mRNA splicing factor Cir_N PF10197.9 CCF41877.1 - 1e-13 51.2 9.6 1e-13 51.2 9.6 3.0 2 1 1 3 3 3 1 N-terminal domain of CBF1 interacting co-repressor CIR Endotoxin_C2 PF18449.1 CCF41877.1 - 0.13 12.7 2.7 1.1 9.6 0.4 2.4 2 0 0 2 2 2 0 Delta endotoxin FYVE_2 PF02318.16 CCF41877.1 - 3.3 7.9 6.6 6.5 7.0 6.6 1.4 1 0 0 1 1 1 0 FYVE-type zinc finger Ank_2 PF12796.7 CCF41881.1 - 3.6e-50 168.5 15.7 1.4e-13 51.2 0.1 6.8 3 2 5 8 8 7 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CCF41881.1 - 1.8e-37 127.2 5.8 5.2e-10 39.6 0.1 8.5 2 2 7 9 9 9 6 Ankyrin repeats (many copies) Ank PF00023.30 CCF41881.1 - 4.2e-35 118.7 11.2 7.5e-07 29.3 0.0 9.1 8 1 1 9 9 9 6 Ankyrin repeat Ank_5 PF13857.6 CCF41881.1 - 4.9e-33 112.8 5.2 6.5e-11 42.3 0.1 7.5 4 2 5 9 9 8 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCF41881.1 - 2.8e-30 100.9 9.1 8e-05 22.8 0.0 11.8 12 1 1 13 13 11 6 Ankyrin repeat NACHT PF05729.12 CCF41881.1 - 3.3e-07 30.4 0.0 9.8e-07 28.8 0.0 1.8 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 CCF41881.1 - 4.1e-06 27.3 0.1 2.2e-05 24.9 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 CCF41881.1 - 1.9e-05 25.0 0.0 6.3e-05 23.3 0.0 1.9 1 0 0 1 1 1 1 AAA domain PNP_UDP_1 PF01048.20 CCF41881.1 - 0.00036 19.9 0.0 0.00083 18.7 0.0 1.6 1 0 0 1 1 1 1 Phosphorylase superfamily KAP_NTPase PF07693.14 CCF41881.1 - 0.0015 17.8 0.8 0.12 11.6 0.3 2.3 1 1 1 2 2 2 1 KAP family P-loop domain AAA PF00004.29 CCF41881.1 - 0.0079 16.6 0.0 0.12 12.8 0.0 3.0 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 CCF41881.1 - 0.0088 15.8 0.0 0.022 14.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CCF41881.1 - 0.014 15.9 0.0 0.043 14.4 0.0 1.9 1 0 0 1 1 1 0 AAA domain Glycos_transf_2 PF00535.26 CCF41881.1 - 0.016 15.0 0.0 0.045 13.6 0.0 1.7 1 0 0 1 1 1 0 Glycosyl transferase family 2 RNA_helicase PF00910.22 CCF41881.1 - 0.047 14.1 0.1 0.17 12.3 0.0 2.0 2 0 0 2 2 1 0 RNA helicase ABC_tran PF00005.27 CCF41881.1 - 0.051 14.1 0.0 0.61 10.6 0.0 2.4 2 0 0 2 2 2 0 ABC transporter AAA_29 PF13555.6 CCF41881.1 - 0.087 12.6 0.0 0.47 10.2 0.0 2.1 2 0 0 2 2 2 0 P-loop containing region of AAA domain DUF87 PF01935.17 CCF41881.1 - 0.16 12.0 0.0 0.6 10.1 0.0 1.9 2 0 0 2 2 2 0 Helicase HerA, central domain CorA PF01544.18 CCF41882.1 - 0.0028 17.0 2.9 0.021 14.1 3.1 2.1 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein Mit_KHE1 PF10173.9 CCF41882.1 - 0.026 14.6 0.0 0.21 11.7 0.0 2.1 2 0 0 2 2 2 0 Mitochondrial K+-H+ exchange-related Ferric_reduct PF01794.19 CCF41883.1 - 4.7e-19 68.7 8.7 1.1e-18 67.6 8.7 1.6 1 0 0 1 1 1 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 CCF41883.1 - 1.8e-17 63.9 0.0 2.8e-17 63.3 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain NAD_binding_1 PF00175.21 CCF41883.1 - 2.2e-06 28.3 0.0 0.0041 17.7 0.0 2.6 2 0 0 2 2 2 2 Oxidoreductase NAD-binding domain FAD_binding_8 PF08022.12 CCF41883.1 - 1.7e-05 24.9 0.0 7.9e-05 22.7 0.0 2.0 1 1 0 1 1 1 1 FAD-binding domain VanZ PF04892.12 CCF41884.1 - 1.5e-08 35.3 3.5 2.2e-08 34.8 3.5 1.3 1 0 0 1 1 1 1 VanZ like family ZT_dimer PF16916.5 CCF41885.1 - 6.1e-08 32.7 0.0 1.1e-07 31.9 0.0 1.4 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter MRP-L27 PF09809.9 CCF41886.1 - 2.3e-17 62.8 0.5 3e-17 62.5 0.5 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L27 P5CR_dimer PF14748.6 CCF41890.1 - 9.1e-36 122.2 0.2 9.1e-36 122.2 0.2 2.6 4 1 0 4 4 4 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 CCF41890.1 - 6e-18 65.2 2.9 1.6e-17 63.8 2.9 1.8 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 CCF41890.1 - 0.003 17.8 0.6 0.0059 16.8 0.6 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase CoA_binding PF02629.19 CCF41890.1 - 0.019 15.7 1.6 0.049 14.3 0.7 2.1 2 0 0 2 2 2 0 CoA binding domain Shikimate_DH PF01488.20 CCF41890.1 - 0.065 13.3 0.4 0.14 12.3 0.1 1.8 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase NAD_Gly3P_dh_N PF01210.23 CCF41890.1 - 0.69 9.9 3.5 0.7 9.9 0.1 2.3 2 1 1 3 3 3 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Hexapep_2 PF14602.6 CCF41892.1 - 2.2e-18 65.7 18.2 5.2e-10 38.9 5.7 2.4 2 0 0 2 2 2 2 Hexapeptide repeat of succinyl-transferase Hexapep PF00132.24 CCF41892.1 - 6.7e-15 54.1 18.3 1.1e-09 37.6 4.7 3.7 2 1 1 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Mac PF12464.8 CCF41892.1 - 8.5e-14 51.5 0.2 5.5e-13 49.0 0.1 2.4 3 0 0 3 3 3 1 Maltose acetyltransferase Zn_clus PF00172.18 CCF41892.1 - 1.3e-09 38.0 8.6 2.5e-09 37.1 8.6 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ABC_membrane_2 PF06472.15 CCF41893.1 - 1.5e-93 313.1 0.1 2.1e-93 312.6 0.1 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 CCF41893.1 - 7.5e-16 58.9 0.0 1.3e-15 58.1 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_16 PF13191.6 CCF41893.1 - 0.0092 16.4 0.0 0.023 15.1 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.6 CCF41893.1 - 0.0093 15.8 0.0 0.018 14.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA PF00004.29 CCF41893.1 - 0.02 15.3 0.0 0.042 14.3 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 CCF41893.1 - 0.022 14.5 0.0 0.048 13.4 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 CCF41893.1 - 0.035 13.5 0.1 0.06 12.7 0.1 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 CCF41893.1 - 0.066 12.9 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_7 PF12775.7 CCF41893.1 - 0.15 11.6 0.0 0.26 10.8 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region T2SSE PF00437.20 CCF41893.1 - 0.17 10.9 0.0 0.28 10.2 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_23 PF13476.6 CCF41893.1 - 0.19 12.2 0.0 0.49 10.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain G-patch PF01585.23 CCF41894.1 - 6.2e-05 22.8 0.0 0.00025 20.9 0.0 2.2 1 1 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 CCF41894.1 - 0.087 12.9 0.0 0.087 12.9 0.0 4.7 4 1 0 4 4 4 0 G-patch domain DUF936 PF06075.12 CCF41894.1 - 4.7 6.0 40.9 6 5.7 40.9 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) CDC27 PF09507.10 CCF41894.1 - 9.2 5.5 66.1 14 5.0 66.1 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 COX17 PF05051.13 CCF41895.1 - 5.7e-21 74.6 6.1 6.8e-21 74.3 6.1 1.1 1 0 0 1 1 1 1 Cytochrome C oxidase copper chaperone (COX17) RRM_1 PF00076.22 CCF41897.1 - 2.3e-13 49.7 0.0 1.9e-06 27.6 0.0 3.0 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CCF41897.1 - 0.062 13.4 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif OxoGdeHyase_C PF16870.5 CCF41897.1 - 0.063 13.0 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 2-oxoglutarate dehydrogenase C-terminal Pkinase PF00069.25 CCF41898.1 - 5e-51 173.6 0.1 4.5e-34 118.0 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCF41898.1 - 5.3e-22 78.3 0.8 1.5e-19 70.3 0.4 3.7 2 1 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF41898.1 - 0.00019 20.8 0.0 0.0008 18.8 0.0 1.9 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 CCF41898.1 - 0.0026 17.7 0.1 0.011 15.7 0.1 2.1 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CCF41898.1 - 0.021 13.6 0.0 0.048 12.4 0.0 1.5 1 0 0 1 1 1 0 Fungal protein kinase DUF2514 PF10721.9 CCF41898.1 - 0.045 13.8 0.0 0.12 12.3 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2514) SPT6_acidic PF14632.6 CCF41898.1 - 7.4 7.2 7.1 17 6.1 0.6 3.2 2 0 0 2 2 2 0 Acidic N-terminal SPT6 Clathrin PF00637.20 CCF41899.1 - 7.5e-25 87.5 2.8 4.3e-23 81.8 0.6 2.6 2 0 0 2 2 2 1 Region in Clathrin and VPS VPS11_C PF12451.8 CCF41899.1 - 5.1e-20 71.4 0.1 1.2e-19 70.2 0.1 1.7 1 0 0 1 1 1 1 Vacuolar protein sorting protein 11 C terminal zf-C3H2C3 PF17122.5 CCF41899.1 - 7.1e-08 32.4 7.4 1.6e-07 31.2 7.4 1.7 1 0 0 1 1 1 1 Zinc-finger zf-C3HC4_2 PF13923.6 CCF41899.1 - 7.7e-06 25.7 7.9 1.8e-05 24.4 7.9 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CCF41899.1 - 0.00074 19.8 7.2 0.0021 18.3 7.2 1.9 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 CCF41899.1 - 0.0055 16.6 6.6 0.012 15.6 6.6 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 CCF41899.1 - 0.0086 16.1 3.8 0.026 14.5 3.8 1.8 1 0 0 1 1 1 1 RING-type zinc-finger Curto_V2 PF07325.11 CCF41899.1 - 0.13 12.1 1.0 0.3 10.9 1.0 1.5 1 0 0 1 1 1 0 Curtovirus V2 protein zf-ANAPC11 PF12861.7 CCF41899.1 - 0.21 11.7 1.5 0.62 10.1 1.5 1.8 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 CCF41899.1 - 0.27 11.0 3.8 0.84 9.4 3.8 1.9 1 0 0 1 1 1 0 RING-like zinc finger zf-rbx1 PF12678.7 CCF41899.1 - 0.76 10.1 6.3 2 8.8 6.3 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 CCF41899.1 - 3 7.8 11.3 0.67 9.9 7.1 2.1 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zinc_ribbon_6 PF14599.6 CCF41900.1 - 2.8e-24 84.9 0.0 2.8e-24 84.9 0.0 4.2 3 1 0 3 3 3 1 Zinc-ribbon zf-CHY PF05495.12 CCF41900.1 - 1.8e-19 70.0 21.1 1.8e-19 70.0 21.1 3.8 3 1 0 3 3 3 1 CHY zinc finger zf-RING_2 PF13639.6 CCF41900.1 - 2.2e-07 31.1 9.1 2.2e-07 31.1 9.1 5.4 3 2 3 6 6 6 1 Ring finger domain zf-C3HC4_2 PF13923.6 CCF41900.1 - 6.4e-05 22.7 7.5 6.4e-05 22.7 7.5 5.2 3 1 2 5 5 5 1 Zinc finger, C3HC4 type (RING finger) MCPVI PF02993.14 CCF41900.1 - 9.9 5.9 9.0 7.4 6.3 3.1 2.1 2 0 0 2 2 2 0 Minor capsid protein VI MOZART1 PF12554.8 CCF41901.1 - 3.2e-26 90.8 0.7 3.9e-26 90.6 0.7 1.1 1 0 0 1 1 1 1 Mitotic-spindle organizing gamma-tubulin ring associated Rrn6 PF10214.9 CCF41902.1 - 5.1e-199 663.8 8.3 9.8e-199 662.9 8.3 1.4 1 1 0 1 1 1 1 RNA polymerase I-specific transcription-initiation factor PITH PF06201.13 CCF41903.1 - 1.7e-43 148.4 0.0 2.1e-43 148.2 0.0 1.1 1 0 0 1 1 1 1 PITH domain CTD_bind PF04818.13 CCF41904.1 - 2.5e-07 31.4 0.0 4.7e-07 30.5 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase II-binding domain. RRM_1 PF00076.22 CCF41904.1 - 1.3e-06 28.1 0.0 2.3e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 CCF41904.1 - 0.029 14.4 0.0 0.084 12.9 0.0 1.7 2 0 0 2 2 2 0 RNA binding motif RRM_occluded PF16842.5 CCF41904.1 - 0.14 12.0 0.0 0.28 11.1 0.0 1.4 1 0 0 1 1 1 0 Occluded RNA-recognition motif Citrate_synt PF00285.21 CCF41905.1 - 4.5e-101 338.5 0.0 5.8e-101 338.1 0.0 1.1 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain Eclosion PF04736.12 CCF41905.1 - 0.033 13.9 0.0 0.07 12.8 0.0 1.5 1 0 0 1 1 1 0 Eclosion hormone DAO PF01266.24 CCF41906.1 - 2.2e-33 116.3 0.1 2.8e-33 116.0 0.1 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 CCF41906.1 - 0.0001 22.3 0.3 0.093 12.7 0.0 3.2 3 0 0 3 3 3 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 CCF41906.1 - 0.00087 18.6 0.0 1.1 8.5 0.0 3.3 3 1 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 CCF41906.1 - 0.041 12.7 0.1 0.22 10.3 0.0 1.9 2 0 0 2 2 2 0 Tryptophan halogenase NAD_binding_7 PF13241.6 CCF41906.1 - 0.1 13.0 0.0 0.22 12.0 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding DHBP_synthase PF00926.19 CCF41907.1 - 1.1e-06 28.3 0.0 1.3e-06 28.0 0.0 1.1 1 0 0 1 1 1 1 3,4-dihydroxy-2-butanone 4-phosphate synthase NatB_MDM20 PF09797.9 CCF41907.1 - 0.013 14.5 0.0 0.013 14.4 0.0 1.0 1 0 0 1 1 1 0 N-acetyltransferase B complex (NatB) non catalytic subunit p450 PF00067.22 CCF41908.1 - 2.1e-49 168.5 0.0 1.4e-35 123.0 0.0 2.0 2 0 0 2 2 2 2 Cytochrome P450 ADH_zinc_N PF00107.26 CCF41910.1 - 3.6e-20 72.3 0.0 5.4e-20 71.7 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 CCF41910.1 - 1.4e-19 70.0 0.0 4e-19 68.5 0.0 1.7 2 0 0 2 2 2 1 N-terminal domain of oxidoreductase ADH_zinc_N_2 PF13602.6 CCF41910.1 - 2.3e-07 31.9 0.0 4.1e-07 31.1 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase FA_desaturase PF00487.24 CCF41912.1 - 1.5e-30 106.9 19.0 2.1e-30 106.4 19.0 1.2 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 CCF41912.1 - 1.3e-09 38.1 0.0 2.6e-09 37.1 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain ASL_C2 PF14698.6 CCF41913.1 - 0.0035 18.0 0.1 0.0049 17.6 0.1 1.2 1 0 0 1 1 1 1 Argininosuccinate lyase C-terminal Chitin_bind_1 PF00187.19 CCF41915.1 - 0.01 16.3 5.1 0.01 16.3 5.1 2.4 2 0 0 2 2 2 0 Chitin recognition protein Na_H_Exchanger PF00999.21 CCF41916.1 - 1.6e-59 201.6 48.6 2.2e-59 201.2 48.6 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Peptidase_M3 PF01432.20 CCF41919.1 - 1.1e-155 519.4 0.0 1.5e-155 519.0 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M3 Peptidase_M2 PF01401.18 CCF41919.1 - 0.032 12.9 0.1 0.67 8.5 0.0 2.1 2 0 0 2 2 2 0 Angiotensin-converting enzyme EF-hand_7 PF13499.6 CCF41920.1 - 2.6e-13 50.2 0.3 2.7e-08 34.2 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.6 CCF41920.1 - 5.2e-12 45.9 0.0 1.5e-05 25.2 0.0 2.5 2 1 0 2 2 2 2 EF-hand domain EF-hand_6 PF13405.6 CCF41920.1 - 2.7e-10 39.3 0.5 0.0034 17.2 0.0 3.8 4 0 0 4 4 4 2 EF-hand domain EF-hand_1 PF00036.32 CCF41920.1 - 6.6e-10 37.8 0.2 0.019 14.5 0.0 3.9 4 1 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 CCF41920.1 - 1.5e-08 34.4 0.2 3.6e-05 23.5 0.1 3.2 3 0 0 3 3 3 2 EF-hand domain pair FGAR-AT_linker PF18072.1 CCF41920.1 - 0.13 12.8 0.1 6.9 7.3 0.1 2.3 2 0 0 2 2 2 0 Formylglycinamide ribonucleotide amidotransferase linker domain EF-hand_14 PF17959.1 CCF41920.1 - 0.18 12.2 0.0 16 5.9 0.0 2.2 2 0 0 2 2 2 0 EF-hand domain HET PF06985.11 CCF41923.1 - 1.8e-20 73.8 0.0 4.8e-20 72.4 0.0 1.7 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Asp PF00026.23 CCF41924.1 - 5.4e-57 193.6 0.0 6.6e-57 193.3 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCF41924.1 - 7.1e-15 55.7 0.9 1e-13 51.9 0.9 2.2 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Ribonuc_L-PSP PF01042.21 CCF41925.1 - 1.2e-15 57.6 0.0 1.5e-15 57.3 0.0 1.1 1 0 0 1 1 1 1 Endoribonuclease L-PSP Sulfotransfer_4 PF17784.1 CCF41926.1 - 4.1e-51 173.8 0.0 4.8e-51 173.6 0.0 1.0 1 0 0 1 1 1 1 Sulfotransferase domain RVT_3 PF13456.6 CCF41926.1 - 0.11 12.3 0.0 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 Reverse transcriptase-like Ribosomal_L27 PF01016.19 CCF41928.1 - 1.1e-25 89.5 0.0 2.4e-25 88.3 0.0 1.6 1 0 0 1 1 1 1 Ribosomal L27 protein Rad4 PF03835.15 CCF41929.1 - 1.4e-14 54.0 1.8 2.4e-14 53.2 1.8 1.4 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain Transglut_core PF01841.19 CCF41929.1 - 1e-11 45.3 1.7 2e-11 44.3 1.7 1.5 1 0 0 1 1 1 1 Transglutaminase-like superfamily p450 PF00067.22 CCF41930.1 - 5.5e-49 167.2 0.0 9.8e-49 166.3 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 MFS_1 PF07690.16 CCF41931.1 - 7.5e-41 140.2 57.7 2e-38 132.2 56.2 2.9 2 1 0 2 2 2 1 Major Facilitator Superfamily MFS_1_like PF12832.7 CCF41931.1 - 0.00047 19.1 13.8 0.00047 19.1 13.8 2.4 2 0 0 2 2 2 2 MFS_1 like family OTT_1508_deam PF14441.6 CCF41933.1 - 8.6e-06 25.7 0.0 1.9e-05 24.6 0.0 1.6 1 0 0 1 1 1 1 OTT_1508-like deaminase COG5 PF10392.9 CCF41933.1 - 0.054 13.7 0.1 0.78 9.9 0.0 2.2 2 0 0 2 2 2 0 Golgi transport complex subunit 5 Gln-synt_C PF00120.24 CCF41935.1 - 7.6e-74 248.8 0.0 1.1e-73 248.2 0.0 1.2 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Amidohydro_2 PF04909.14 CCF41935.1 - 3.2e-14 53.4 0.1 9.7e-14 51.8 0.1 1.8 1 0 0 1 1 1 1 Amidohydrolase Dynamin_N PF00350.23 CCF41936.1 - 3.5e-21 76.0 0.0 3.7e-20 72.7 0.0 2.4 1 1 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 CCF41936.1 - 1.2e-12 47.7 0.3 7.8e-08 31.9 0.1 2.2 2 0 0 2 2 2 2 Dynamin central region GED PF02212.18 CCF41936.1 - 2.3e-05 24.4 0.0 6.6e-05 23.0 0.0 1.7 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 CCF41936.1 - 0.00054 20.0 0.1 0.013 15.5 0.0 3.0 2 1 0 2 2 2 1 50S ribosome-binding GTPase CdvA PF18822.1 CCF41936.1 - 0.17 11.7 0.7 1.2 9.0 0.0 2.3 2 0 0 2 2 2 0 CdvA-like coiled-coil domain Sugar_tr PF00083.24 CCF41937.1 - 3.3e-83 280.1 21.4 3.8e-83 279.9 21.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF41937.1 - 2.6e-25 89.1 20.3 3.8e-25 88.6 20.3 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.6 CCF41937.1 - 4.5e-05 22.2 1.0 4.5e-05 22.2 1.0 3.1 3 1 0 3 3 3 2 MFS/sugar transport protein PTR2 PF00854.21 CCF41937.1 - 0.00087 18.2 2.5 0.00087 18.2 2.5 1.7 2 0 0 2 2 2 1 POT family Methyltransf_23 PF13489.6 CCF41938.1 - 1.2e-12 48.0 0.0 1.7e-12 47.5 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF41938.1 - 1.3e-05 25.8 0.0 3.9e-05 24.2 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF41938.1 - 1.7e-05 25.4 0.0 8.7e-05 23.2 0.0 2.2 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF41938.1 - 5.7e-05 23.8 0.0 0.00018 22.2 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF41938.1 - 0.1 12.4 0.0 0.22 11.3 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase domain MFS_1 PF07690.16 CCF41939.1 - 3.4e-16 59.1 8.2 4.1e-16 58.9 8.2 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF41939.1 - 2.2e-09 36.7 0.2 2.6e-09 36.5 0.2 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_4 PF06779.14 CCF41939.1 - 1e-07 31.6 2.0 1.2e-07 31.3 2.0 1.1 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB OppC_N PF12911.7 CCF41939.1 - 0.033 14.2 1.7 0.36 10.8 0.0 2.4 1 1 1 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C Pam17 PF08566.10 CCF41939.1 - 0.14 12.0 0.0 0.21 11.4 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial import protein Pam17 Ceramidase_alk PF04734.13 CCF41940.1 - 1e-211 704.0 0.0 1.2e-211 703.8 0.0 1.0 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, N-terminal Ceramidse_alk_C PF17048.5 CCF41940.1 - 5.4e-58 195.6 0.0 9.1e-58 194.8 0.0 1.4 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, C-terminal ADAM17_MPD PF16698.5 CCF41941.1 - 0.056 13.8 0.0 0.071 13.5 0.0 1.1 1 0 0 1 1 1 0 Membrane-proximal domain, switch, for ADAM17 Transferase PF02458.15 CCF41942.1 - 1.5e-18 66.7 0.0 5e-15 55.1 0.0 2.7 2 1 0 2 2 2 2 Transferase family Condensation PF00668.20 CCF41942.1 - 0.11 11.2 0.0 0.15 10.7 0.0 1.1 1 0 0 1 1 1 0 Condensation domain BTB PF00651.31 CCF41943.1 - 3.1e-07 30.6 0.0 5e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain DUF2347 PF09804.9 CCF41945.1 - 0.03 13.9 0.8 0.034 13.7 0.8 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) PEHE PF15275.6 CCF41945.1 - 0.031 14.9 4.9 0.032 14.9 4.9 1.1 1 0 0 1 1 1 0 PEHE domain Eapp_C PF10238.9 CCF41945.1 - 0.046 13.8 2.5 0.046 13.8 2.5 1.1 1 0 0 1 1 1 0 E2F-associated phosphoprotein DUF2235 PF09994.9 CCF41945.1 - 0.068 12.5 0.9 0.066 12.6 0.9 1.0 1 0 0 1 1 1 0 Uncharacterized alpha/beta hydrolase domain (DUF2235) Peptidase_S49_N PF08496.10 CCF41945.1 - 0.069 13.2 4.3 0.072 13.1 4.3 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal EIIBC-GUT_N PF03612.14 CCF41945.1 - 0.077 12.7 2.5 0.078 12.7 2.5 1.0 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Topoisom_I_N PF02919.15 CCF41945.1 - 0.079 12.5 5.3 0.086 12.3 5.3 1.0 1 0 0 1 1 1 0 Eukaryotic DNA topoisomerase I, DNA binding fragment Med19 PF10278.9 CCF41945.1 - 0.088 12.7 8.5 0.1 12.6 8.5 1.1 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 Rrn6 PF10214.9 CCF41945.1 - 0.46 8.9 7.8 0.44 9.0 7.8 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Connexin PF00029.19 CCF41945.1 - 0.62 9.8 2.4 0.64 9.7 2.4 1.0 1 0 0 1 1 1 0 Connexin NARP1 PF12569.8 CCF41945.1 - 1.3 7.9 10.5 1.4 7.7 10.5 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Presenilin PF01080.17 CCF41945.1 - 1.5 7.5 3.5 1.4 7.6 3.5 1.0 1 0 0 1 1 1 0 Presenilin Coilin_N PF15862.5 CCF41945.1 - 1.5 8.6 8.9 1.7 8.4 8.9 1.1 1 0 0 1 1 1 0 Coilin N-terminus MscS_TM PF12794.7 CCF41945.1 - 6.3 5.6 7.4 7 5.4 7.4 1.0 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 COesterase PF00135.28 CCF41946.1 - 1.2e-91 308.1 0.0 1.5e-91 307.8 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CCF41946.1 - 0.00041 20.3 0.3 0.00099 19.0 0.3 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CCF41946.1 - 0.0085 15.6 0.1 0.013 15.0 0.1 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 CCF41946.1 - 0.14 12.7 2.7 0.61 10.7 2.7 2.2 1 1 0 1 1 1 0 Alpha/beta hydrolase family DCAF15_WD40 PF14939.6 CCF41946.1 - 0.16 11.6 0.0 0.29 10.8 0.0 1.3 1 0 0 1 1 1 0 DDB1-and CUL4-substrate receptor 15, WD repeat GMC_oxred_N PF00732.19 CCF41948.1 - 2.3e-42 145.4 0.0 6.8e-42 143.9 0.0 1.7 1 1 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 CCF41948.1 - 4.5e-05 22.7 0.2 0.11 11.6 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain Thi4 PF01946.17 CCF41948.1 - 0.0011 18.2 0.0 0.0021 17.4 0.0 1.4 1 0 0 1 1 1 1 Thi4 family Lycopene_cycl PF05834.12 CCF41948.1 - 0.0081 15.3 0.1 0.013 14.6 0.1 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 CCF41948.1 - 0.012 15.9 0.2 0.048 13.9 0.2 2.1 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CCF41948.1 - 0.057 13.0 2.6 0.11 12.0 0.4 2.3 2 1 1 3 3 3 0 FAD dependent oxidoreductase Trp_halogenase PF04820.14 CCF41948.1 - 0.068 12.0 0.1 0.091 11.6 0.1 1.1 1 0 0 1 1 1 0 Tryptophan halogenase HI0933_like PF03486.14 CCF41948.1 - 0.075 11.7 0.0 0.12 11.1 0.0 1.3 1 0 0 1 1 1 0 HI0933-like protein Acetyltransf_1 PF00583.25 CCF41950.1 - 6.7e-13 48.9 0.0 8.4e-13 48.6 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CCF41950.1 - 3.6e-09 36.6 0.0 5.1e-09 36.1 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 CCF41950.1 - 6.7e-05 23.6 0.0 8.4e-05 23.3 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CCF41950.1 - 0.00018 21.9 0.0 0.00026 21.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CCF41950.1 - 0.00032 20.6 0.0 0.00052 19.9 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 CCF41950.1 - 0.043 13.9 0.0 0.065 13.4 0.0 1.3 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase MFS_1 PF07690.16 CCF41951.1 - 2.5e-05 23.4 7.1 3.6e-05 22.9 7.1 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Fungal_trans PF04082.18 CCF41954.1 - 2.4e-14 53.0 0.0 4.1e-14 52.2 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF41954.1 - 4.9e-08 33.0 12.9 4.9e-08 33.0 12.9 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PepX_C PF08530.10 CCF41956.1 - 3.8e-33 115.3 0.0 6.9e-33 114.5 0.0 1.4 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain Peptidase_S15 PF02129.18 CCF41956.1 - 7.2e-05 22.5 0.1 0.00012 21.7 0.1 1.3 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) EthD PF07110.11 CCF41956.1 - 8.3e-05 23.7 0.0 0.0004 21.5 0.0 2.2 2 0 0 2 2 2 1 EthD domain MmlI PF09448.10 CCF41956.1 - 0.0014 19.0 0.0 1.1 9.7 0.0 2.8 3 0 0 3 3 3 2 Methylmuconolactone methyl-isomerase DUF4440 PF14534.6 CCF41957.1 - 4e-12 46.5 0.0 4.8e-12 46.2 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) DUF2981 PF11200.8 CCF41958.1 - 0.0068 16.2 0.9 0.015 15.1 0.8 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF2981) RNA_Me_trans PF04252.13 CCF41959.1 - 1.6e-84 282.5 0.0 1.8e-84 282.3 0.0 1.0 1 0 0 1 1 1 1 Predicted SAM-dependent RNA methyltransferase Glyco_hydro_127 PF07944.12 CCF41960.1 - 6.2e-92 308.7 0.0 8.3e-92 308.3 0.0 1.0 1 0 0 1 1 1 1 Beta-L-arabinofuranosidase, GH127 ABC_tran PF00005.27 CCF41961.1 - 2.5e-41 141.4 0.1 2e-20 73.7 0.0 2.9 3 0 0 3 3 2 2 ABC transporter ABC_membrane PF00664.23 CCF41961.1 - 2.9e-24 86.2 15.2 2.9e-24 86.2 15.2 1.6 2 0 0 2 2 1 1 ABC transporter transmembrane region AAA_21 PF13304.6 CCF41961.1 - 3.4e-13 50.1 3.9 0.0028 17.5 0.0 4.3 2 2 2 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CCF41961.1 - 6.1e-09 35.6 0.7 0.0053 16.2 0.1 4.2 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CCF41961.1 - 3.6e-06 26.6 0.1 0.12 12.1 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 CCF41961.1 - 0.00011 22.5 0.1 0.15 12.3 0.0 2.7 2 1 0 2 2 2 2 AAA domain AAA_23 PF13476.6 CCF41961.1 - 0.00011 22.7 0.0 0.32 11.5 0.1 2.2 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 CCF41961.1 - 0.00017 21.6 0.4 0.42 10.7 0.1 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CCF41961.1 - 0.00071 19.5 0.0 1.4 8.8 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase Dynamin_N PF00350.23 CCF41961.1 - 0.00074 19.6 0.6 0.19 11.8 0.0 2.3 2 0 0 2 2 2 1 Dynamin family AAA_25 PF13481.6 CCF41961.1 - 0.0011 18.6 0.0 0.98 9.0 0.1 2.7 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 CCF41961.1 - 0.0017 18.9 0.0 2.7 8.5 0.0 2.8 2 1 0 2 2 2 2 AAA domain AAA_33 PF13671.6 CCF41961.1 - 0.0017 18.6 0.0 0.12 12.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_15 PF13175.6 CCF41961.1 - 0.0025 17.6 0.0 0.71 9.5 0.0 2.4 3 0 0 3 3 2 1 AAA ATPase domain T2SSE PF00437.20 CCF41961.1 - 0.0075 15.4 0.0 0.56 9.2 0.0 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_16 PF13191.6 CCF41961.1 - 0.0084 16.5 0.1 1.9 8.8 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain DUF87 PF01935.17 CCF41961.1 - 0.019 15.1 0.0 0.036 14.2 0.0 1.4 1 0 0 1 1 1 0 Helicase HerA, central domain FtsK_SpoIIIE PF01580.18 CCF41961.1 - 0.023 14.1 0.1 2.6 7.3 0.0 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family cobW PF02492.19 CCF41961.1 - 0.025 14.2 0.5 3.4 7.2 0.5 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_7 PF12775.7 CCF41961.1 - 0.093 12.2 0.0 7.4 6.0 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region ABC_ATPase PF09818.9 CCF41961.1 - 2.2 7.0 4.6 0.56 8.9 0.3 2.1 3 0 0 3 3 3 0 Predicted ATPase of the ABC class AMP-binding PF00501.28 CCF41962.1 - 9.4e-137 456.1 0.0 3e-67 227.1 0.0 3.0 3 0 0 3 3 3 2 AMP-binding enzyme Condensation PF00668.20 CCF41962.1 - 2.6e-84 283.5 0.0 3.1e-41 141.5 0.0 3.2 3 0 0 3 3 3 3 Condensation domain PP-binding PF00550.25 CCF41962.1 - 1.7e-28 98.8 0.4 9.6e-14 51.5 0.0 3.3 3 0 0 3 3 3 2 Phosphopantetheine attachment site AMP-binding_C PF13193.6 CCF41962.1 - 7.4e-09 36.5 0.2 0.00081 20.3 0.0 3.1 2 0 0 2 2 2 2 AMP-binding enzyme C-terminal domain DUF3243 PF11588.8 CCF41962.1 - 0.021 15.1 0.1 4.1 7.8 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3243) Cation_efflux PF01545.21 CCF41963.1 - 2.6e-47 161.2 5.0 3.5e-47 160.7 5.0 1.2 1 0 0 1 1 1 1 Cation efflux family Anoctamin PF04547.12 CCF41963.1 - 2.9 6.6 4.9 0.31 9.8 0.1 1.7 2 0 0 2 2 2 0 Calcium-activated chloride channel Rax2 PF12768.7 CCF41965.1 - 0.00068 19.2 0.2 0.0011 18.5 0.2 1.3 1 0 0 1 1 1 1 Cortical protein marker for cell polarity Amnionless PF14828.6 CCF41965.1 - 0.0051 15.7 0.1 0.007 15.3 0.1 1.2 1 0 0 1 1 1 1 Amnionless TMEM154 PF15102.6 CCF41965.1 - 0.079 12.9 0.2 0.11 12.4 0.2 1.2 1 0 0 1 1 1 0 TMEM154 protein family Romo1 PF10247.9 CCF41965.1 - 0.1 13.0 0.0 0.2 12.1 0.0 1.4 1 0 0 1 1 1 0 Reactive mitochondrial oxygen species modulator 1 VSP PF03302.13 CCF41965.1 - 0.11 11.3 0.1 0.13 11.1 0.1 1.1 1 0 0 1 1 1 0 Giardia variant-specific surface protein MtrF PF09472.10 CCF41965.1 - 0.2 11.1 0.9 0.39 10.1 0.9 1.4 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) CcmD PF04995.14 CCF41965.1 - 0.66 10.1 6.4 0.29 11.2 2.3 2.3 2 0 0 2 2 2 0 Heme exporter protein D (CcmD) Dynactin_p62 PF05502.13 CCF41967.1 - 0.016 14.0 1.2 0.018 13.8 1.2 1.0 1 0 0 1 1 1 0 Dynactin p62 family AAA_17 PF13207.6 CCF41969.1 - 1e-10 42.1 0.0 1.3e-10 41.9 0.0 1.0 1 0 0 1 1 1 1 AAA domain KAP_NTPase PF07693.14 CCF41969.1 - 6.2e-06 25.7 0.0 6.2e-06 25.7 0.0 1.1 1 0 0 1 1 1 1 KAP family P-loop domain AAA_16 PF13191.6 CCF41969.1 - 4.7e-05 23.8 0.0 4.7e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain MeaB PF03308.16 CCF41969.1 - 0.0009 18.3 0.0 0.0021 17.1 0.0 1.5 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA PF00004.29 CCF41969.1 - 0.0015 18.9 0.0 0.0016 18.9 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CCF41969.1 - 0.0046 17.2 0.0 0.005 17.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 CCF41969.1 - 0.0047 17.1 0.0 0.0056 16.9 0.0 1.1 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 CCF41969.1 - 0.005 16.1 0.0 0.005 16.1 0.0 1.2 1 0 0 1 1 1 1 Zeta toxin NB-ARC PF00931.22 CCF41969.1 - 0.0074 15.5 0.0 0.011 15.0 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain Viral_helicase1 PF01443.18 CCF41969.1 - 0.01 15.6 0.0 0.011 15.5 0.0 1.1 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase RNA_helicase PF00910.22 CCF41969.1 - 0.011 16.1 0.0 0.012 16.0 0.0 1.2 1 0 0 1 1 1 0 RNA helicase Torsin PF06309.11 CCF41969.1 - 0.013 15.6 0.0 0.014 15.5 0.0 1.2 1 0 0 1 1 1 0 Torsin ATPase_2 PF01637.18 CCF41969.1 - 0.018 14.9 0.0 0.026 14.4 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_18 PF13238.6 CCF41969.1 - 0.025 15.1 0.0 0.027 15.0 0.0 1.1 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CCF41969.1 - 0.034 14.7 0.0 0.04 14.4 0.0 1.3 1 1 0 1 1 1 0 ABC transporter NACHT PF05729.12 CCF41969.1 - 0.042 13.8 0.0 0.061 13.2 0.0 1.2 1 0 0 1 1 1 0 NACHT domain AAA_14 PF13173.6 CCF41969.1 - 0.057 13.5 0.0 0.061 13.4 0.0 1.3 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 CCF41969.1 - 0.066 13.5 0.0 0.071 13.3 0.0 1.1 1 0 0 1 1 1 0 AAA domain DAP3 PF10236.9 CCF41969.1 - 0.075 12.2 0.0 0.088 12.0 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_30 PF13604.6 CCF41969.1 - 0.079 12.7 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 CCF41969.1 - 0.082 12.9 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Virul_Fac PF10139.9 CCF41969.1 - 0.099 10.8 0.0 0.1 10.8 0.0 1.2 1 0 0 1 1 1 0 Putative bacterial virulence factor GBP PF02263.19 CCF41969.1 - 0.11 11.8 0.0 0.11 11.7 0.0 1.1 1 0 0 1 1 1 0 Guanylate-binding protein, N-terminal domain MMR_HSR1 PF01926.23 CCF41969.1 - 0.11 12.6 0.0 0.12 12.4 0.0 1.4 1 1 0 1 1 1 0 50S ribosome-binding GTPase DUF815 PF05673.13 CCF41969.1 - 0.13 11.4 0.0 0.17 11.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF815) APS_kinase PF01583.20 CCF41969.1 - 0.13 12.2 0.0 0.16 11.9 0.0 1.1 1 0 0 1 1 1 0 Adenylylsulphate kinase RsgA_GTPase PF03193.16 CCF41969.1 - 0.13 12.2 0.0 0.13 12.2 0.0 1.2 1 0 0 1 1 1 0 RsgA GTPase AAA_24 PF13479.6 CCF41969.1 - 0.16 11.7 0.0 0.17 11.6 0.0 1.2 1 1 0 1 1 1 0 AAA domain DUF2791 PF10923.8 CCF41969.1 - 0.16 10.8 0.0 0.21 10.4 0.0 1.1 1 0 0 1 1 1 0 P-loop Domain of unknown function (DUF2791) DAO PF01266.24 CCF41970.1 - 1.4e-17 64.3 0.0 1.8e-17 64.0 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase HEM4 PF02602.15 CCF41970.1 - 0.066 12.6 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 Uroporphyrinogen-III synthase HemD Cu-oxidase_3 PF07732.15 CCF41971.1 - 7.9e-42 142.0 2.0 5e-41 139.5 0.2 2.8 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 CCF41971.1 - 4.6e-30 104.1 4.9 1.5e-25 89.6 0.2 3.8 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 CCF41971.1 - 8.5e-16 58.5 0.0 1.3e-14 54.7 0.0 2.5 2 1 0 2 2 2 1 Multicopper oxidase Aldedh PF00171.22 CCF41972.1 - 7.2e-113 377.5 0.0 8.8e-113 377.2 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family zf-H2C2_2 PF13465.6 CCF41975.1 - 1.6e-09 37.8 18.6 2e-05 24.8 3.5 4.1 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2 PF00096.26 CCF41975.1 - 2.5e-06 27.6 20.8 0.00045 20.5 4.5 3.1 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCF41975.1 - 0.0013 19.4 16.1 0.051 14.4 3.1 3.2 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CCF41975.1 - 0.053 13.8 0.4 0.053 13.8 0.4 3.1 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding FOXP-CC PF16159.5 CCF41975.1 - 0.11 13.1 0.1 0.11 13.1 0.1 2.7 2 1 1 3 3 3 0 FOXP coiled-coil domain zf-C2H2_6 PF13912.6 CCF41975.1 - 0.23 11.5 5.8 2.4 8.3 0.3 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger DUF2225 PF09986.9 CCF41975.1 - 0.29 10.8 0.8 0.61 9.8 0.8 1.6 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2225) zf-H2C2_5 PF13909.6 CCF41975.1 - 2.9 7.7 12.9 3.1 7.6 0.1 3.7 3 0 0 3 3 3 0 C2H2-type zinc-finger domain Amino_oxidase PF01593.24 CCF41976.1 - 2.2e-54 185.5 0.1 2.9e-54 185.1 0.1 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CCF41976.1 - 7.8e-15 54.9 0.2 6.2e-13 48.8 0.1 2.6 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 CCF41976.1 - 4.6e-10 39.4 0.2 6.2e-10 39.0 0.2 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 CCF41976.1 - 1.2e-07 30.8 0.2 8.8e-06 24.7 0.2 2.1 2 0 0 2 2 2 1 HI0933-like protein DAO PF01266.24 CCF41976.1 - 5.5e-07 29.5 0.3 1.6e-06 27.9 0.1 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CCF41976.1 - 8e-07 28.5 0.7 1.5e-06 27.6 0.7 1.4 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CCF41976.1 - 1.3e-05 24.6 0.2 9.8e-05 21.7 0.0 2.3 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCF41976.1 - 2.2e-05 23.9 0.1 0.038 13.2 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CCF41976.1 - 2.4e-05 23.6 0.6 0.00022 20.4 0.1 2.1 2 0 0 2 2 2 1 Glucose inhibited division protein A Pyr_redox PF00070.27 CCF41976.1 - 0.00019 21.9 3.1 0.00035 21.1 0.1 2.7 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CCF41976.1 - 0.00077 18.8 0.0 0.0013 18.0 0.0 1.2 1 0 0 1 1 1 1 Thi4 family AlaDh_PNT_C PF01262.21 CCF41976.1 - 0.015 14.6 0.3 0.19 11.0 0.0 2.1 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_9 PF13454.6 CCF41976.1 - 0.17 11.9 1.4 29 4.6 0.1 3.0 3 0 0 3 3 3 0 FAD-NAD(P)-binding DUF2263 PF10021.9 CCF41978.1 - 1.8e-20 73.8 0.0 4.4e-20 72.5 0.0 1.7 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2263) Apt1 PF10351.9 CCF41978.1 - 0.27 10.1 1.1 0.33 9.8 1.1 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF908 PF06012.12 CCF41978.1 - 2 7.7 5.9 2.7 7.3 5.9 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) AAA PF00004.29 CCF41979.1 - 6.6e-13 49.2 0.0 1.1e-12 48.5 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) BCS1_N PF08740.11 CCF41979.1 - 1.5e-12 47.9 0.0 2.3e-12 47.3 0.0 1.3 1 0 0 1 1 1 1 BCS1 N terminal Dynamin_N PF00350.23 CCF41979.1 - 0.25 11.4 0.1 0.54 10.3 0.0 1.5 2 0 0 2 2 2 0 Dynamin family Pkinase PF00069.25 CCF41980.1 - 6.7e-12 45.3 0.0 5.8e-11 42.3 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF41980.1 - 0.00031 20.1 0.0 0.00042 19.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF41980.1 - 0.17 11.2 0.0 0.23 10.7 0.0 1.1 1 0 0 1 1 1 0 Kinase-like CLIP1_ZNF PF16641.5 CCF41981.1 - 2.4e-07 30.4 13.2 0.0017 18.2 3.0 2.3 2 0 0 2 2 2 2 CLIP1 zinc knuckle C1_2 PF03107.16 CCF41981.1 - 0.0019 18.5 2.7 0.17 12.2 0.4 2.3 2 0 0 2 2 2 2 C1 domain DivIC PF04977.15 CCF41981.1 - 0.039 13.7 4.4 0.12 12.1 2.1 2.1 2 0 0 2 2 2 0 Septum formation initiator zf_PR_Knuckle PF18445.1 CCF41981.1 - 0.93 9.4 3.7 10 6.0 0.2 2.5 2 0 0 2 2 2 0 PR zinc knuckle motif zf-CCHC_4 PF14392.6 CCF41981.1 - 1.3 8.8 4.4 9.1 6.1 0.2 2.3 2 0 0 2 2 2 0 Zinc knuckle Ribonuc_L-PSP PF01042.21 CCF41982.1 - 1.4e-16 60.6 0.0 2.3e-16 59.9 0.0 1.2 1 0 0 1 1 1 1 Endoribonuclease L-PSP HD PF01966.22 CCF41982.1 - 0.00011 22.4 0.1 0.00026 21.2 0.1 1.7 1 0 0 1 1 1 1 HD domain RVT_2 PF07727.14 CCF41983.1 - 6.8e-08 32.5 0.0 1.1e-07 31.7 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 CCF41983.1 - 1.7e-07 31.5 0.1 5.5e-07 29.8 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain gag_pre-integrs PF13976.6 CCF41983.1 - 6.5e-05 22.7 1.8 0.00018 21.3 1.8 1.7 1 0 0 1 1 1 1 GAG-pre-integrase domain AT_hook PF02178.19 CCF41983.1 - 0.11 12.4 1.6 0.25 11.4 1.6 1.6 1 0 0 1 1 1 0 AT hook motif LigB PF02900.18 CCF41984.1 - 4.5e-33 114.5 0.1 5.4e-33 114.2 0.1 1.0 1 0 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase p47_phox_C PF08944.11 CCF41986.1 - 0.031 13.7 3.0 0.068 12.6 3.0 1.5 1 0 0 1 1 1 0 NADPH oxidase subunit p47Phox, C terminal domain p450 PF00067.22 CCF41988.1 - 2.9e-23 82.4 0.0 4.1e-23 81.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Cys_Met_Meta_PP PF01053.20 CCF41989.1 - 4.5e-10 38.6 0.0 5.1e-10 38.4 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme ATP-grasp_2 PF08442.10 CCF41991.1 - 1.8e-77 259.5 1.2 1.8e-77 259.5 1.2 1.8 2 0 0 2 2 2 1 ATP-grasp domain Ligase_CoA PF00549.19 CCF41991.1 - 6.1e-27 94.3 0.5 1.2e-26 93.3 0.5 1.5 1 0 0 1 1 1 1 CoA-ligase ATP-grasp_5 PF13549.6 CCF41991.1 - 7.5e-08 32.1 0.2 1.9e-07 30.8 0.2 1.7 1 0 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.19 CCF41991.1 - 0.001 18.9 2.4 0.04 13.7 0.2 2.6 2 1 0 2 2 2 2 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ABC2_membrane PF01061.24 CCF41992.1 - 6.4e-86 287.1 47.1 8.5e-49 165.8 20.1 2.3 2 0 0 2 2 2 2 ABC-2 type transporter ABC_tran PF00005.27 CCF41992.1 - 3.5e-39 134.4 0.0 3.2e-18 66.5 0.0 2.6 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 CCF41992.1 - 5.3e-28 96.8 7.6 4.1e-26 90.7 0.0 3.6 3 0 0 3 3 3 2 CDR ABC transporter ABC_trans_N PF14510.6 CCF41992.1 - 1.4e-08 35.3 0.2 1.4e-08 35.3 0.2 2.2 3 0 0 3 3 1 1 ABC-transporter N-terminal ABC2_membrane_3 PF12698.7 CCF41992.1 - 1.6e-08 34.1 36.2 2e-06 27.2 11.3 2.7 3 1 0 3 3 3 2 ABC-2 family transporter protein AAA_16 PF13191.6 CCF41992.1 - 5.1e-07 30.2 0.1 0.00044 20.7 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 CCF41992.1 - 5.9e-05 23.0 0.1 0.013 15.4 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_25 PF13481.6 CCF41992.1 - 0.00041 20.0 0.1 0.016 14.8 0.1 2.3 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 CCF41992.1 - 0.0006 19.5 0.5 0.099 12.4 0.2 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_18 PF13238.6 CCF41992.1 - 0.00062 20.3 0.0 1 9.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.6 CCF41992.1 - 0.00078 19.6 0.0 0.98 9.6 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_28 PF13521.6 CCF41992.1 - 0.0013 19.0 1.3 1.2 9.4 0.5 2.4 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 CCF41992.1 - 0.0026 18.1 0.5 0.96 9.7 0.1 3.1 2 1 0 2 2 2 1 AAA domain cobW PF02492.19 CCF41992.1 - 0.007 16.0 1.0 1.7 8.2 0.3 2.3 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.6 CCF41992.1 - 0.023 14.4 0.2 7.5 6.2 0.2 2.3 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 CCF41992.1 - 0.071 13.2 0.2 15 5.7 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase NACHT PF05729.12 CCF41992.1 - 0.1 12.5 0.7 4.8 7.1 0.3 2.4 2 0 0 2 2 2 0 NACHT domain T2SSE PF00437.20 CCF41992.1 - 0.13 11.3 0.1 1.1 8.2 0.0 2.1 2 0 0 2 2 2 0 Type II/IV secretion system protein PduV-EutP PF10662.9 CCF41992.1 - 0.21 11.3 0.4 8.8 6.1 0.2 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation DnaB_C PF03796.15 CCF41992.1 - 0.22 10.8 0.1 1.4 8.2 0.0 2.0 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain Fungal_trans PF04082.18 CCF41993.1 - 3.9e-12 45.8 0.2 5.8e-12 45.2 0.2 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF41993.1 - 1.8e-08 34.4 11.0 3.3e-08 33.5 11.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain tRNA-synt_2_TM PF16995.5 CCF41993.1 - 0.032 13.9 0.4 8.6 6.0 0.2 2.3 2 0 0 2 2 2 0 Transmembrane region of lysyl-tRNA synthetase PhoU PF01895.19 CCF41993.1 - 0.048 14.1 0.2 0.12 12.9 0.2 1.6 1 0 0 1 1 1 0 PhoU domain Lip_A_acyltrans PF03279.13 CCF41993.1 - 0.12 11.6 0.0 0.22 10.7 0.0 1.3 1 0 0 1 1 1 0 Bacterial lipid A biosynthesis acyltransferase Fungal_trans_2 PF11951.8 CCF41994.1 - 3.3e-40 138.1 0.0 4.4e-40 137.7 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF41994.1 - 6.1e-07 29.5 12.6 1e-06 28.7 12.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RR_TM4-6 PF06459.12 CCF41996.1 - 0.26 11.1 19.3 0.31 10.8 19.3 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DDHD PF02862.17 CCF41996.1 - 0.34 11.0 3.6 0.35 11.0 3.6 1.2 1 0 0 1 1 1 0 DDHD domain Plasmodium_Vir PF05795.11 CCF41996.1 - 0.34 10.3 11.9 0.47 9.8 11.9 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Tim54 PF11711.8 CCF41996.1 - 0.42 9.4 17.8 0.56 8.9 17.8 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 SpoIIP PF07454.11 CCF41996.1 - 0.43 10.0 10.2 0.51 9.8 10.2 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF4820 PF16091.5 CCF41996.1 - 1.4 8.2 8.4 1.6 8.0 8.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) DUF4746 PF15928.5 CCF41996.1 - 1.6 8.1 15.1 1.9 7.8 15.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) FGF-BP1 PF06473.12 CCF41996.1 - 1.7 8.4 13.9 2.1 8.1 13.9 1.2 1 0 0 1 1 1 0 FGF binding protein 1 (FGF-BP1) Paf1 PF03985.13 CCF41996.1 - 1.8 7.5 20.2 2 7.3 20.2 1.1 1 0 0 1 1 1 0 Paf1 Borrelia_P83 PF05262.11 CCF41996.1 - 1.8 6.9 23.6 2.1 6.7 23.6 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein NARP1 PF12569.8 CCF41996.1 - 1.9 7.3 21.9 2.2 7.1 21.9 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Connexin PF00029.19 CCF41996.1 - 2 8.1 7.9 2.5 7.8 7.9 1.3 1 0 0 1 1 1 0 Connexin DUF913 PF06025.12 CCF41996.1 - 2.5 7.0 6.9 2.7 6.9 6.9 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) CPSF100_C PF13299.6 CCF41996.1 - 2.8 8.1 13.5 4.4 7.5 13.5 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF3807 PF12720.7 CCF41996.1 - 3.2 8.0 19.7 4.3 7.6 19.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) NPR3 PF03666.13 CCF41996.1 - 4.8 5.9 13.4 5.5 5.7 13.4 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Vfa1 PF08432.10 CCF41996.1 - 7.3 6.9 25.9 10 6.4 25.9 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF4834 PF16118.5 CCF41996.1 - 7.8 7.5 10.7 78 4.3 8.9 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Ribosomal_60s PF00428.19 CCF41997.1 - 0.94 10.1 9.0 1.4 9.5 9.0 1.2 1 0 0 1 1 1 0 60s Acidic ribosomal protein MFS_1 PF07690.16 CCF42000.1 - 4.2e-37 127.9 46.8 4.2e-37 127.9 46.8 2.5 2 1 0 2 2 2 1 Major Facilitator Superfamily DUF2929 PF11151.8 CCF42000.1 - 0.065 13.5 0.8 0.065 13.5 0.8 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2929) Ketoacyl-synt_C PF02801.22 CCF42001.1 - 1.1e-14 54.4 0.0 1.9e-14 53.7 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain MFS_1 PF07690.16 CCF42002.1 - 2.7e-11 43.0 0.3 6.7e-11 41.7 0.1 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF42002.1 - 4.7e-10 38.9 2.5 8e-10 38.2 2.5 1.5 1 1 0 1 1 1 1 Sugar (and other) transporter TRI12 PF06609.13 CCF42002.1 - 0.00036 19.1 0.4 0.0005 18.6 0.4 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) S_4TM PF18159.1 CCF42002.1 - 0.15 11.4 2.6 10 5.3 0.0 3.0 3 0 0 3 3 3 0 SMODS-associating 4TM effector domain MFS_1 PF07690.16 CCF42003.1 - 1.8e-40 138.9 27.1 2.7e-40 138.4 27.1 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF42003.1 - 2.4e-09 36.6 7.9 8e-09 34.9 7.9 1.9 1 0 0 1 1 1 1 Sugar (and other) transporter TRI12 PF06609.13 CCF42003.1 - 0.00017 20.2 5.1 0.00017 20.2 5.1 1.8 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) DUF3040 PF11239.8 CCF42003.1 - 0.32 11.3 10.6 2.8 8.3 0.0 4.1 4 1 0 4 4 4 0 Protein of unknown function (DUF3040) HEAT PF02985.22 CCF42004.1 - 4.9e-33 110.4 12.5 0.012 15.8 0.1 11.2 12 0 0 12 12 12 8 HEAT repeat HEAT_2 PF13646.6 CCF42004.1 - 1.5e-29 102.2 6.1 2.3e-11 43.9 0.0 6.3 2 2 4 7 7 7 7 HEAT repeats Cnd1 PF12717.7 CCF42004.1 - 8.1e-11 42.2 8.4 6.6e-05 23.0 0.1 4.8 3 1 1 5 5 5 3 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 CCF42004.1 - 1.6e-10 41.2 3.7 0.012 16.1 0.1 6.4 7 2 1 8 8 8 2 HEAT-like repeat Vac14_Fab1_bd PF12755.7 CCF42004.1 - 2.4e-09 37.7 4.4 0.048 14.3 0.1 6.4 3 1 4 7 7 7 2 Vacuolar 14 Fab1-binding region RTP1_C1 PF10363.9 CCF42004.1 - 8.9e-07 29.1 5.5 0.13 12.4 0.1 5.1 4 1 1 5 5 5 2 Required for nuclear transport of RNA pol II C-terminus 1 Adaptin_N PF01602.20 CCF42004.1 - 6.6e-05 21.7 9.5 0.0041 15.7 0.2 4.2 1 1 2 5 5 5 2 Adaptin N terminal region CLASP_N PF12348.8 CCF42004.1 - 0.0029 17.2 3.3 0.46 10.0 0.2 4.2 2 2 1 3 3 3 1 CLASP N terminal M11L PF11099.8 CCF42004.1 - 0.0063 16.8 0.3 2.9 8.2 0.0 3.3 2 1 2 4 4 4 1 Apoptosis regulator M11L like Ecm29 PF13001.7 CCF42004.1 - 0.012 14.3 4.2 0.17 10.5 0.0 3.4 3 1 1 4 4 4 0 Proteasome stabiliser Proteasom_PSMB PF10508.9 CCF42004.1 - 0.014 13.9 6.0 0.27 9.7 0.1 2.5 2 1 0 2 2 2 0 Proteasome non-ATPase 26S subunit Nop52 PF05997.12 CCF42004.1 - 0.083 12.7 0.0 0.74 9.6 0.0 2.6 3 1 0 3 3 3 0 Nucleolar protein,Nop52 Arm PF00514.23 CCF42004.1 - 0.11 12.6 3.3 22 5.3 0.0 4.7 6 0 0 6 6 6 0 Armadillo/beta-catenin-like repeat API5 PF05918.11 CCF42004.1 - 3.5 6.3 8.3 0.61 8.8 0.4 3.3 4 1 0 5 5 5 0 Apoptosis inhibitory protein 5 (API5) Calreticulin PF00262.18 CCF42005.1 - 8.8e-122 406.5 22.6 1.4e-121 405.8 22.6 1.3 1 0 0 1 1 1 1 Calreticulin family Aldedh PF00171.22 CCF42006.1 - 2.8e-58 197.6 0.2 3.9e-58 197.1 0.2 1.2 1 0 0 1 1 1 1 Aldehyde dehydrogenase family p450 PF00067.22 CCF42007.1 - 1.7e-52 178.7 0.0 2.2e-52 178.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 LicD PF04991.13 CCF42010.1 - 9.7e-24 84.8 7.9 1.2e-16 61.6 4.0 2.1 1 1 1 2 2 2 2 LicD family WLM PF08325.10 CCF42011.1 - 2.4e-50 171.3 0.1 2.4e-50 171.3 0.1 1.5 2 0 0 2 2 2 1 WLM domain DUF45 PF01863.17 CCF42011.1 - 4.6e-05 23.6 0.6 9.4e-05 22.6 0.6 1.4 1 0 0 1 1 1 1 Protein of unknown function DUF45 SprT-like PF10263.9 CCF42011.1 - 0.028 14.3 0.2 0.058 13.3 0.2 1.7 1 0 0 1 1 1 0 SprT-like family Reprolysin_5 PF13688.6 CCF42011.1 - 0.059 13.5 0.9 0.1 12.7 0.9 1.6 1 1 0 1 1 1 0 Metallo-peptidase family M12 ubiquitin PF00240.23 CCF42011.1 - 0.11 12.3 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin family ER_lumen_recept PF00810.18 CCF42012.1 - 6.9e-54 182.7 9.9 6.9e-54 182.7 9.9 1.4 2 0 0 2 2 2 1 ER lumen protein retaining receptor PQ-loop PF04193.14 CCF42012.1 - 0.059 13.2 9.2 1 9.2 1.0 3.2 3 0 0 3 3 3 0 PQ loop repeat ISET-FN3_linker PF16625.5 CCF42014.1 - 0.04 14.4 1.7 0.072 13.6 0.9 1.9 1 1 1 2 2 2 0 Unstructured linking region I-set and fnIII on Brother of CDO CorA PF01544.18 CCF42018.1 - 0.074 12.4 0.0 0.1 11.9 0.0 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein DcrB PF08786.11 CCF42018.1 - 0.1 12.7 0.3 5.3 7.2 0.0 2.1 2 0 0 2 2 2 0 DcrB Fungal_trans PF04082.18 CCF42019.1 - 2.4e-19 69.4 0.0 4.3e-19 68.6 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF42019.1 - 5e-09 36.1 11.0 1.1e-08 35.1 11.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Aa_trans PF01490.18 CCF42020.1 - 3.5e-30 105.0 34.5 4e-30 104.8 34.5 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein AA_permease_2 PF13520.6 CCF42020.1 - 0.0045 15.9 45.3 0.44 9.3 45.3 2.8 1 1 0 1 1 1 1 Amino acid permease DUF872 PF05915.12 CCF42020.1 - 0.19 11.9 2.0 15 5.8 0.3 3.3 2 1 1 3 3 3 0 Eukaryotic protein of unknown function (DUF872) SLATT_1 PF18181.1 CCF42020.1 - 3.6 7.5 11.3 7.3 6.5 3.6 3.1 3 0 0 3 3 3 0 SMODS and SLOG-associating 2TM effector domain 1 p450 PF00067.22 CCF42021.1 - 5.5e-65 219.9 0.0 6.4e-65 219.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Thioesterase PF00975.20 CCF42023.1 - 6.6e-23 82.0 0.0 2.3e-22 80.3 0.0 1.7 1 1 0 1 1 1 1 Thioesterase domain Hydrolase_4 PF12146.8 CCF42023.1 - 0.064 12.5 0.0 0.085 12.1 0.0 1.1 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CCF42023.1 - 0.11 13.1 2.6 0.16 12.6 2.6 1.4 1 1 0 1 1 1 0 Alpha/beta hydrolase family Sugar_tr PF00083.24 CCF42025.1 - 4.5e-34 118.1 10.9 5e-34 117.9 10.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF42025.1 - 5.6e-07 28.8 19.5 6.5e-07 28.6 18.5 1.5 1 1 1 2 2 2 1 Major Facilitator Superfamily DUF3021 PF11457.8 CCF42025.1 - 0.63 10.4 10.4 1 9.7 10.4 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3021) Fungal_trans PF04082.18 CCF42026.1 - 6.1e-06 25.5 0.0 1.2e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain AMP-binding PF00501.28 CCF42027.1 - 4.7e-59 200.1 0.9 5.3e-42 143.9 0.0 3.1 1 1 1 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.6 CCF42027.1 - 3.5e-12 47.1 0.4 8e-12 46.0 0.4 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain IF4E PF01652.18 CCF42028.1 - 3.1e-47 160.3 0.0 3.8e-47 160.0 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E APH PF01636.23 CCF42030.1 - 2.4e-14 53.8 0.0 4.1e-14 53.1 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 CCF42030.1 - 9.7e-05 21.8 0.0 0.00015 21.2 0.0 1.2 1 0 0 1 1 1 1 Ecdysteroid kinase DUF1679 PF07914.11 CCF42030.1 - 0.027 13.4 0.0 0.038 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) Zn_clus PF00172.18 CCF42031.1 - 1.2e-06 28.6 7.0 2.3e-06 27.6 7.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 CCF42031.1 - 0.011 14.5 1.6 0.024 13.5 1.6 1.6 1 1 0 1 1 1 0 Fungal specific transcription factor domain Vac14_Fig4_bd PF11916.8 CCF42032.1 - 0.018 14.7 0.0 0.024 14.3 0.0 1.1 1 0 0 1 1 1 0 Vacuolar protein 14 C-terminal Fig4p binding Methyltransf_2 PF00891.18 CCF42033.1 - 4.9e-18 65.2 0.0 6.1e-18 64.9 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase domain Condensation PF00668.20 CCF42034.1 - 3.1e-89 299.8 0.0 4.4e-89 299.3 0.0 1.1 1 0 0 1 1 1 1 Condensation domain AMP-binding PF00501.28 CCF42034.1 - 5.3e-81 272.4 0.0 6.8e-81 272.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.25 CCF42034.1 - 4.9e-13 49.2 0.3 3.1e-12 46.7 0.1 2.4 2 0 0 2 2 2 1 Phosphopantetheine attachment site AMP-binding_C PF13193.6 CCF42034.1 - 1.1e-06 29.6 0.4 0.0047 17.9 0.0 3.1 2 0 0 2 2 2 2 AMP-binding enzyme C-terminal domain DDE_1 PF03184.19 CCF42035.1 - 6.8e-14 51.9 0.0 8.3e-14 51.6 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Vps26 PF03643.15 CCF42037.1 - 1.1e-130 434.5 0.8 1.3e-130 434.3 0.8 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.29 CCF42037.1 - 0.00022 21.3 0.6 0.51 10.4 0.0 3.5 2 1 2 4 4 4 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 CCF42037.1 - 0.0065 16.9 0.0 0.065 13.7 0.0 2.3 1 1 1 2 2 2 1 Arrestin (or S-antigen), C-terminal domain IL17R_D_N PF16742.5 CCF42037.1 - 0.065 13.3 0.1 0.14 12.2 0.1 1.5 1 0 0 1 1 1 0 N-terminus of interleukin 17 receptor D p450 PF00067.22 CCF42038.1 - 6.9e-34 117.4 0.0 1.6e-33 116.1 0.0 1.5 1 1 0 1 1 1 1 Cytochrome P450 Mre11_DNA_bind PF04152.14 CCF42039.1 - 2e-53 181.2 2.8 2.5e-53 180.9 0.4 2.3 2 0 0 2 2 2 1 Mre11 DNA-binding presumed domain Fip1 PF05182.13 CCF42039.1 - 0.11 12.0 0.1 0.23 11.0 0.1 1.5 1 0 0 1 1 1 0 Fip1 motif PBP1_TM PF14812.6 CCF42039.1 - 0.58 10.6 9.9 2.4 8.6 1.1 3.9 3 1 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal NusG_II PF07009.11 CCF42040.1 - 0.048 13.9 0.0 0.06 13.6 0.0 1.1 1 0 0 1 1 1 0 NusG domain II LIAS_N PF16881.5 CCF42041.1 - 5.5e-17 62.1 0.0 8.2e-17 61.6 0.0 1.4 1 1 0 1 1 1 1 N-terminal domain of lipoyl synthase of Radical_SAM family Radical_SAM PF04055.21 CCF42041.1 - 0.035 14.5 0.0 0.054 13.9 0.0 1.3 1 0 0 1 1 1 0 Radical SAM superfamily Acyl_transf_3 PF01757.22 CCF42042.1 - 5e-11 42.3 1.4 1.1e-10 41.1 0.7 1.7 2 0 0 2 2 2 1 Acyltransferase family CReP_N PF10472.9 CCF42042.1 - 0.037 12.9 0.3 0.044 12.6 0.3 1.1 1 0 0 1 1 1 0 eIF2-alpha phosphatase phosphorylation constitutive repressor GFO_IDH_MocA PF01408.22 CCF42044.1 - 8.1e-14 52.5 0.0 8.8e-14 52.4 0.0 1.1 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold COesterase PF00135.28 CCF42045.1 - 6.9e-77 259.4 0.0 1.2e-76 258.6 0.0 1.3 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CCF42045.1 - 0.0013 18.6 0.3 0.0063 16.4 0.3 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Glyco_hydro_12 PF01670.16 CCF42046.1 - 8.9e-15 55.3 8.1 1.8e-11 44.4 2.3 2.1 1 1 1 2 2 2 2 Glycosyl hydrolase family 12 Qn_am_d_aIV PF09100.10 CCF42046.1 - 0.051 13.4 0.3 0.15 11.9 0.1 1.9 1 1 1 2 2 2 0 Quinohemoprotein amine dehydrogenase, alpha subunit domain IV PseudoU_synth_1 PF01416.20 CCF42047.1 - 2.3e-12 47.3 0.0 1.7e-10 41.3 0.0 2.8 3 0 0 3 3 3 1 tRNA pseudouridine synthase DUF2344 PF10105.9 CCF42047.1 - 0.0081 16.0 0.0 0.069 13.0 0.0 2.1 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2344) T3SS_needle_F PF09392.10 CCF42047.1 - 0.15 12.3 0.0 0.32 11.2 0.0 1.5 1 0 0 1 1 1 0 Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF Tannase PF07519.11 CCF42048.1 - 1.9e-92 310.6 0.6 2.2e-92 310.4 0.6 1.0 1 0 0 1 1 1 1 Tannase and feruloyl esterase Peptidase_S9 PF00326.21 CCF42048.1 - 6.7e-05 22.5 0.0 0.069 12.6 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 CCF42048.1 - 0.00013 21.3 0.0 0.086 12.1 0.0 2.5 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CCF42048.1 - 0.0028 17.3 0.1 0.0073 16.0 0.1 1.7 1 0 0 1 1 1 1 alpha/beta hydrolase fold ADH_zinc_N_2 PF13602.6 CCF42049.1 - 1.2e-27 97.5 0.0 2.2e-27 96.7 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 CCF42049.1 - 3.6e-19 69.0 1.1 1.3e-18 67.2 0.1 2.3 3 0 0 3 3 3 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCF42049.1 - 0.01 15.7 0.0 0.096 12.6 0.0 2.3 1 1 1 2 2 2 0 Alcohol dehydrogenase GroES-like domain GRDP-like PF07173.12 CCF42050.1 - 2.8e-10 41.0 0.4 0.0017 19.0 0.0 3.2 3 0 0 3 3 3 2 Glycine-rich domain-containing protein-like MFS_1 PF07690.16 CCF42053.1 - 7.1e-05 21.9 5.2 8.7e-05 21.6 5.2 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Glyco_hydro_3 PF00933.21 CCF42054.1 - 2.9e-26 92.6 0.3 8.2e-16 58.3 0.0 2.2 2 0 0 2 2 2 2 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.22 CCF42054.1 - 0.0011 18.9 0.0 0.002 18.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain PfkB PF00294.24 CCF42055.1 - 7.7e-17 61.5 0.0 2e-16 60.2 0.0 1.5 1 1 0 1 1 1 1 pfkB family carbohydrate kinase Sushi_2 PF09014.10 CCF42055.1 - 0.079 12.9 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 Beta-2-glycoprotein-1 fifth domain FA_hydroxylase PF04116.13 CCF42057.1 - 1.4e-16 61.1 6.5 1.4e-16 61.1 6.5 2.0 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily ThiF PF00899.21 CCF42057.1 - 0.12 11.7 0.1 2.3 7.5 0.7 2.0 1 1 0 2 2 2 0 ThiF family Glyco_trans_2_3 PF13632.6 CCF42058.1 - 0.1 12.5 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase family group 2 DAO_C PF16901.5 CCF42059.1 - 1.9e-39 134.4 0.0 1.9e-38 131.2 0.0 2.1 2 0 0 2 2 2 1 C-terminal domain of alpha-glycerophosphate oxidase DAO PF01266.24 CCF42059.1 - 1.2e-08 35.0 0.0 1.9e-08 34.3 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase adh_short_C2 PF13561.6 CCF42060.1 - 8.5e-51 172.8 0.0 1.1e-50 172.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF42060.1 - 1.8e-30 105.8 0.0 2.6e-30 105.4 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF42060.1 - 3.8e-07 30.2 0.0 5e-07 29.8 0.0 1.2 1 0 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 CCF42060.1 - 0.022 14.2 0.0 4.3 6.6 0.0 2.1 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase Acetate_kinase PF00871.17 CCF42060.1 - 0.088 11.5 0.0 0.11 11.1 0.0 1.2 1 0 0 1 1 1 0 Acetokinase family DUF1682 PF07946.14 CCF42062.1 - 3.1e-114 381.6 1.1 3.5e-114 381.4 1.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) Big_3 PF07523.12 CCF42062.1 - 0.0078 16.5 0.3 1.6 9.1 0.1 2.4 2 0 0 2 2 2 2 Bacterial Ig-like domain (group 3) DUF5486 PF17588.2 CCF42062.1 - 0.3 11.0 2.4 0.71 9.8 2.4 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5486) DUF2140 PF09911.9 CCF42062.1 - 0.57 9.7 0.0 0.57 9.7 0.0 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2140) DUF4407 PF14362.6 CCF42062.1 - 2 7.7 7.8 3 7.1 7.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Thiamine_BP PF01910.17 CCF42063.1 - 2.4e-14 53.0 0.1 2.8e-14 52.8 0.1 1.0 1 0 0 1 1 1 1 Thiamine-binding protein Cyto_heme_lyase PF01265.17 CCF42066.1 - 2.5e-38 132.3 0.8 2.5e-37 129.1 0.8 1.9 1 1 0 1 1 1 1 Cytochrome c/c1 heme lyase ABC1 PF03109.16 CCF42067.1 - 3.6e-22 78.8 0.1 5.6e-22 78.1 0.1 1.3 1 0 0 1 1 1 1 ABC1 family APH PF01636.23 CCF42067.1 - 7.2e-05 22.8 0.5 0.0082 16.1 0.0 2.7 2 1 0 2 2 2 2 Phosphotransferase enzyme family DCB PF16213.5 CCF42068.1 - 2.7e-47 160.7 3.0 5.7e-47 159.7 3.0 1.5 1 0 0 1 1 1 1 Dimerisation and cyclophilin-binding domain of Mon2 Sec7_N PF12783.7 CCF42068.1 - 1.2e-42 145.5 0.7 3e-41 141.0 0.1 2.3 2 0 0 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal UQ_con PF00179.26 CCF42069.1 - 1.7e-16 60.1 0.0 1.9e-16 60.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 CCF42069.1 - 0.0024 18.1 0.0 0.0025 18.1 0.0 1.2 1 0 0 1 1 1 1 RWD domain Band_7 PF01145.25 CCF42070.1 - 3.1e-31 108.8 0.5 5.5e-31 107.9 0.5 1.4 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_C PF16200.5 CCF42070.1 - 2e-22 79.0 2.6 3.3e-22 78.3 1.5 2.1 2 0 0 2 2 2 1 C-terminal region of band_7 Pox_A11 PF05061.13 CCF42070.1 - 0.013 14.8 0.3 0.021 14.1 0.3 1.4 1 0 0 1 1 1 0 Poxvirus A11 Protein GSH-S_N PF02951.14 CCF42070.1 - 0.096 12.8 0.1 0.2 11.8 0.1 1.6 1 0 0 1 1 1 0 Prokaryotic glutathione synthetase, N-terminal domain Zn_clus PF00172.18 CCF42073.1 - 9.5e-05 22.4 10.7 0.00016 21.8 10.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CCF42073.1 - 0.029 13.4 0.1 0.049 12.6 0.1 1.3 1 0 0 1 1 1 0 Fungal specific transcription factor domain RhoGAP PF00620.27 CCF42074.1 - 2.5e-44 150.8 0.4 8e-44 149.1 0.3 1.9 2 0 0 2 2 2 1 RhoGAP domain PH PF00169.29 CCF42074.1 - 9.6e-12 45.4 0.0 1.9e-11 44.4 0.0 1.6 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 CCF42074.1 - 0.0091 16.3 0.1 0.18 12.1 0.0 2.4 2 0 0 2 2 2 1 Pleckstrin homology domain AgrB PF04647.15 CCF42076.1 - 0.068 12.5 0.0 0.25 10.6 0.0 1.8 1 1 1 2 2 2 0 Accessory gene regulator B R3H-assoc PF13902.6 CCF42077.1 - 3e-24 85.9 1.5 6.4e-24 84.9 1.1 1.7 2 0 0 2 2 2 1 R3H-associated N-terminal domain AXE1 PF05448.12 CCF42078.1 - 0.24 10.1 0.0 0.38 9.4 0.0 1.2 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) CFEM PF05730.11 CCF42079.1 - 8.6e-12 45.0 9.9 1.5e-11 44.2 9.9 1.4 1 0 0 1 1 1 1 CFEM domain Sugar_tr PF00083.24 CCF42080.1 - 1.9e-20 73.2 21.3 7.4e-16 58.1 13.4 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter ADH_N PF08240.12 CCF42081.1 - 9.2e-13 48.0 4.0 1.6e-12 47.3 0.3 2.6 2 1 1 3 3 3 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCF42081.1 - 1e-06 28.8 0.5 2.2e-06 27.7 0.5 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 CCF42081.1 - 0.0055 16.0 0.4 0.0078 15.5 0.4 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain TrkA_N PF02254.18 CCF42081.1 - 0.019 15.2 0.3 0.032 14.5 0.3 1.4 1 0 0 1 1 1 0 TrkA-N domain Sacchrp_dh_NADP PF03435.18 CCF42081.1 - 0.12 12.6 0.3 0.18 12.1 0.3 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Reprolysin_5 PF13688.6 CCF42082.1 - 6.6e-06 26.4 0.6 1.2e-05 25.5 0.6 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.6 CCF42082.1 - 7.6e-05 22.4 0.5 0.00014 21.6 0.5 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Pep_M12B_propep PF01562.19 CCF42082.1 - 0.0034 17.6 0.8 0.0059 16.8 0.2 1.6 2 0 0 2 2 2 1 Reprolysin family propeptide AA_permease PF00324.21 CCF42083.1 - 1.8e-100 336.8 36.2 2.2e-100 336.5 36.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CCF42083.1 - 1.5e-30 106.4 42.2 1.8e-30 106.1 42.2 1.1 1 0 0 1 1 1 1 Amino acid permease FKBP_C PF00254.28 CCF42084.1 - 1.5e-27 95.7 0.1 1.9e-27 95.4 0.1 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase DUF3328 PF11807.8 CCF42085.1 - 5.1e-39 134.3 5.5 7.2e-39 133.8 5.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) adh_short_C2 PF13561.6 CCF42086.1 - 5e-22 78.6 0.2 5.4e-22 78.5 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF42086.1 - 1.3e-05 24.7 0.1 1.7e-05 24.4 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase Fungal_trans_2 PF11951.8 CCF42087.1 - 1.2e-10 40.7 0.1 1.4e-10 40.5 0.1 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Fungal_trans PF04082.18 CCF42087.1 - 0.16 10.9 0.3 0.25 10.4 0.3 1.2 1 0 0 1 1 1 0 Fungal specific transcription factor domain Serglycin PF04360.12 CCF42088.1 - 0.54 10.2 5.4 0.8 9.6 5.4 1.4 1 0 0 1 1 1 0 Serglycin HEAT_EZ PF13513.6 CCF42089.1 - 3.6e-31 107.2 8.0 1.2e-15 57.6 0.0 10.0 9 1 2 11 11 11 4 HEAT-like repeat HEAT PF02985.22 CCF42089.1 - 1e-27 93.8 6.3 3.6e-05 23.7 0.0 9.1 8 0 0 8 8 8 6 HEAT repeat HEAT_2 PF13646.6 CCF42089.1 - 7.2e-20 71.2 0.2 0.002 18.5 0.0 6.7 3 3 3 6 6 6 4 HEAT repeats Cnd1 PF12717.7 CCF42089.1 - 3.3e-08 33.7 0.0 0.022 14.8 0.0 4.5 3 2 1 5 5 5 2 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 CCF42089.1 - 4.5e-08 33.6 0.0 0.0064 17.1 0.0 5.3 4 2 4 8 8 8 1 Vacuolar 14 Fab1-binding region MMS19_C PF12460.8 CCF42089.1 - 1.3e-06 27.8 1.8 0.11 11.6 0.0 5.0 5 0 0 5 5 5 2 RNAPII transcription regulator C-terminal CLASP_N PF12348.8 CCF42089.1 - 8.5e-05 22.2 0.1 6.6 6.2 0.0 5.7 4 2 1 6 6 6 1 CLASP N terminal HEAT_PBS PF03130.16 CCF42089.1 - 8.7e-05 22.8 2.8 7.9 7.5 0.1 4.8 4 0 0 4 4 3 1 PBS lyase HEAT-like repeat Adaptin_N PF01602.20 CCF42089.1 - 0.00022 19.9 0.1 0.75 8.3 0.0 3.1 3 1 0 3 3 3 2 Adaptin N terminal region RTP1_C1 PF10363.9 CCF42089.1 - 0.0014 18.8 0.2 0.18 12.0 0.0 3.7 4 0 0 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 Arm PF00514.23 CCF42089.1 - 0.0038 17.2 5.2 4.2 7.5 0.0 5.1 5 1 0 5 5 4 2 Armadillo/beta-catenin-like repeat Gcn1_N PF12074.8 CCF42089.1 - 0.0061 15.9 0.1 2.5 7.3 0.0 3.2 3 0 0 3 3 3 1 Generalcontrol nonderepressible 1 (Gcn1) N-terminal DUF3437 PF11919.8 CCF42089.1 - 0.013 15.4 0.1 2 8.4 0.0 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF3437) BP28CT PF08146.12 CCF42089.1 - 0.016 15.1 0.0 0.33 10.8 0.0 2.9 3 0 0 3 3 3 0 BP28CT (NUC211) domain RIX1 PF08167.12 CCF42089.1 - 0.098 12.4 3.4 17 5.1 0.0 4.8 6 0 0 6 6 6 0 rRNA processing/ribosome biogenesis Tti2 PF10521.9 CCF42089.1 - 0.15 11.5 1.7 2.7 7.4 0.0 3.4 4 1 0 4 4 4 0 Tti2 family ADH_N PF08240.12 CCF42090.1 - 5.8e-18 64.8 0.1 7.6e-18 64.4 0.1 1.1 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain tRNA_SAD PF07973.14 CCF42091.1 - 0.00013 22.0 0.3 0.0003 20.8 0.3 1.6 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain tRNA-synt_2c PF01411.19 CCF42091.1 - 0.00026 19.6 0.0 0.00032 19.3 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (A) GATase PF00117.28 CCF42092.1 - 1.1e-09 38.4 0.0 4.1e-09 36.5 0.0 1.7 2 0 0 2 2 2 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 CCF42092.1 - 0.0003 20.6 0.2 0.00061 19.6 0.2 1.7 1 1 0 1 1 1 1 Peptidase C26 AMP-binding PF00501.28 CCF42093.1 - 5.6e-103 344.8 0.0 4.4e-68 229.8 0.0 2.3 2 0 0 2 2 2 2 AMP-binding enzyme Condensation PF00668.20 CCF42093.1 - 6.6e-55 186.6 0.0 2e-32 112.4 0.0 2.4 2 0 0 2 2 2 2 Condensation domain PP-binding PF00550.25 CCF42093.1 - 6.3e-22 77.7 0.4 2.5e-10 40.5 0.0 2.9 3 0 0 3 3 3 2 Phosphopantetheine attachment site AMP-binding_C PF13193.6 CCF42093.1 - 1.3e-07 32.5 0.0 0.00084 20.3 0.0 2.7 2 0 0 2 2 2 2 AMP-binding enzyme C-terminal domain AF-4 PF05110.13 CCF42093.1 - 9.4 4.2 8.1 16 3.4 8.1 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Candida_ALS PF05792.13 CCF42094.1 - 1.1e-54 182.6 315.8 1.6e-09 38.1 15.0 17.8 19 0 0 19 19 19 15 Candida agglutinin-like (ALS) DUF4185 PF13810.6 CCF42096.1 - 3.2e-13 49.6 0.9 5e-13 49.0 0.9 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4185) p450 PF00067.22 CCF42101.1 - 2.6e-13 49.5 0.0 3.4e-13 49.1 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 Cupin_8 PF13621.6 CCF42103.1 - 3e-36 125.4 0.0 4.1e-36 125.0 0.0 1.2 1 0 0 1 1 1 1 Cupin-like domain Kelch_4 PF13418.6 CCF42103.1 - 5.7e-08 32.7 8.3 9.7e-08 31.9 0.1 4.2 5 0 0 5 5 5 1 Galactose oxidase, central domain Kelch_3 PF13415.6 CCF42103.1 - 4.5e-06 26.8 5.9 0.5 10.7 0.0 5.0 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_5 PF13854.6 CCF42103.1 - 1.9e-05 24.5 0.4 0.55 10.3 0.0 4.3 4 1 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 CCF42103.1 - 0.00013 22.1 4.6 0.085 13.2 0.0 4.3 4 0 0 4 4 4 1 Kelch motif Kelch_1 PF01344.25 CCF42103.1 - 0.00053 19.5 0.1 0.063 12.9 0.0 3.6 3 0 0 3 3 3 1 Kelch motif Cupin_4 PF08007.12 CCF42103.1 - 0.0012 18.4 0.0 0.0033 16.9 0.0 1.7 2 0 0 2 2 2 1 Cupin superfamily protein Kelch_2 PF07646.15 CCF42103.1 - 0.54 10.3 3.9 12 6.0 0.0 3.2 3 0 0 3 3 3 0 Kelch motif MFS_1 PF07690.16 CCF42104.1 - 4.9e-13 48.7 13.9 5.7e-13 48.5 13.9 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily ATG22 PF11700.8 CCF42104.1 - 0.72 8.4 5.9 0.33 9.5 2.4 1.8 1 1 1 2 2 2 0 Vacuole effluxer Atg22 like Sugar_tr PF00083.24 CCF42104.1 - 1.1 8.1 8.7 1.3 7.7 8.7 1.1 1 0 0 1 1 1 0 Sugar (and other) transporter CBP_BcsF PF11120.8 CCF42104.1 - 5.5 7.2 6.1 40 4.4 1.8 2.5 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsF Pkinase PF00069.25 CCF42106.1 - 1.5e-50 172.0 0.1 6.5e-50 169.9 0.1 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF42106.1 - 3e-23 82.4 0.0 5.9e-23 81.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CCF42106.1 - 0.00034 20.6 0.1 0.00034 20.6 0.1 2.3 2 1 1 3 3 3 1 Phosphotransferase enzyme family RIO1 PF01163.22 CCF42106.1 - 0.0028 17.3 0.2 0.0073 15.9 0.2 1.6 1 1 0 1 1 1 1 RIO1 family Choline_kinase PF01633.20 CCF42106.1 - 0.5 9.9 2.0 0.39 10.3 0.2 1.7 2 0 0 2 2 2 0 Choline/ethanolamine kinase RRM_1 PF00076.22 CCF42108.1 - 0.0095 15.7 0.0 0.016 15.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Btz PF09405.10 CCF42108.1 - 0.11 12.7 0.1 0.27 11.5 0.0 1.7 2 0 0 2 2 2 0 CASC3/Barentsz eIF4AIII binding PPR_2 PF13041.6 CCF42109.1 - 2.1e-24 85.4 2.4 1e-16 60.8 0.0 5.8 7 1 1 8 8 8 2 PPR repeat family PPR PF01535.20 CCF42109.1 - 1.3e-11 43.9 6.7 0.027 14.7 0.0 8.1 9 0 0 9 9 8 3 PPR repeat PPR_3 PF13812.6 CCF42109.1 - 2.8e-09 36.9 0.3 0.00097 19.2 0.0 4.9 3 2 2 5 5 5 2 Pentatricopeptide repeat domain PPR_long PF17177.4 CCF42109.1 - 2.8e-07 30.1 3.4 2.1e-06 27.3 0.4 3.2 2 2 2 4 4 4 2 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 CCF42109.1 - 3.2e-06 26.7 6.5 1.9 8.2 0.0 6.8 8 0 0 8 8 8 2 PPR repeat TPR_14 PF13428.6 CCF42109.1 - 0.0013 19.4 3.8 63 4.8 0.0 5.9 4 2 2 6 6 5 0 Tetratricopeptide repeat ATP13 PF12921.7 CCF42109.1 - 0.0025 17.7 0.0 0.012 15.5 0.0 2.2 1 0 0 1 1 1 1 Mitochondrial ATPase expression aGPT-Pplase3 PF18746.1 CCF42109.1 - 0.0039 16.6 0.8 0.68 9.2 0.0 3.1 3 0 0 3 3 3 1 Alpha-glutamyl/putrescinyl thymine pyrophosphorylase clade 3 Clathrin PF00637.20 CCF42109.1 - 0.1 12.5 5.7 3 7.7 0.1 3.2 4 0 0 4 4 4 0 Region in Clathrin and VPS DUF4404 PF14357.6 CCF42109.1 - 0.15 12.7 0.6 3.8 8.2 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) EcsB PF05975.12 CCF42109.1 - 0.15 10.9 0.2 7.8 5.2 0.0 2.3 2 0 0 2 2 2 0 Bacterial ABC transporter protein EcsB UTP15_C PF09384.10 CCF42109.1 - 0.49 10.1 3.7 15 5.2 0.0 3.0 3 1 0 3 3 3 0 UTP15 C terminal Trypsin_2 PF13365.6 CCF42110.1 - 0.025 15.5 0.2 0.3 12.0 0.2 2.4 1 1 0 1 1 1 0 Trypsin-like peptidase domain Peptidase_S64 PF08192.11 CCF42110.1 - 0.05 12.1 0.0 0.18 10.2 0.0 1.8 1 1 0 1 1 1 0 Peptidase family S64 Med13_C PF06333.12 CCF42111.1 - 1e-91 307.6 0.6 1.8e-91 306.9 0.6 1.4 1 0 0 1 1 1 1 Mediator complex subunit 13 C-terminal domain MID_MedPIWI PF18296.1 CCF42111.1 - 1.1e-13 51.6 0.0 6.7e-06 26.1 0.0 2.5 1 1 0 2 2 2 2 MID domain of medPIWI AAA PF00004.29 CCF42112.1 - 4.9e-32 111.1 0.0 1.8e-30 106.0 0.0 2.4 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CCF42112.1 - 2.8e-08 33.4 0.0 5.9e-08 32.4 0.0 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 CCF42112.1 - 3.9e-06 27.4 0.2 9.5e-05 22.8 0.2 2.6 1 1 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.12 CCF42112.1 - 5.2e-06 26.3 0.0 2.2e-05 24.3 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 CCF42112.1 - 5.6e-06 26.4 0.0 1.1e-05 25.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CCF42112.1 - 5e-05 23.6 0.3 0.0055 17.0 0.0 3.2 1 1 1 3 3 3 1 AAA domain AAA_5 PF07728.14 CCF42112.1 - 5e-05 23.3 0.1 0.00052 20.0 0.1 2.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 CCF42112.1 - 8.9e-05 22.7 0.0 0.00018 21.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) TniB PF05621.11 CCF42112.1 - 0.00047 19.6 0.0 1.1 8.6 0.0 2.8 2 1 1 3 3 3 2 Bacterial TniB protein AAA_33 PF13671.6 CCF42112.1 - 0.0011 19.2 0.0 0.002 18.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 CCF42112.1 - 0.0018 17.7 0.1 0.0037 16.7 0.1 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 CCF42112.1 - 0.003 17.9 0.0 0.01 16.2 0.0 1.9 2 0 0 2 2 1 1 RNA helicase AAA_18 PF13238.6 CCF42112.1 - 0.0034 17.9 0.0 0.013 16.0 0.0 2.1 3 0 0 3 3 1 1 AAA domain NACHT PF05729.12 CCF42112.1 - 0.0075 16.2 0.0 0.022 14.7 0.0 1.8 2 0 0 2 2 2 1 NACHT domain AAA_25 PF13481.6 CCF42112.1 - 0.0085 15.7 0.3 0.079 12.5 0.1 2.3 2 1 0 2 2 2 1 AAA domain DUF815 PF05673.13 CCF42112.1 - 0.0095 15.1 0.0 0.018 14.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) IstB_IS21 PF01695.17 CCF42112.1 - 0.0098 15.6 0.0 0.017 14.8 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein Sigma54_activat PF00158.26 CCF42112.1 - 0.012 15.3 0.0 0.031 14.0 0.0 1.6 2 0 0 2 2 1 0 Sigma-54 interaction domain Rad17 PF03215.15 CCF42112.1 - 0.018 15.0 0.0 0.061 13.2 0.0 1.6 1 1 1 2 2 2 0 Rad17 P-loop domain AAA_28 PF13521.6 CCF42112.1 - 0.02 15.1 0.3 0.062 13.6 0.0 2.0 3 0 0 3 3 1 0 AAA domain AAA_24 PF13479.6 CCF42112.1 - 0.021 14.6 0.0 0.031 14.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.13 CCF42112.1 - 0.025 13.8 0.0 0.05 12.8 0.0 1.5 1 0 0 1 1 1 0 TIP49 P-loop domain ATPase_2 PF01637.18 CCF42112.1 - 0.028 14.3 0.1 0.15 12.0 0.0 2.0 1 1 0 2 2 2 0 ATPase domain predominantly from Archaea Zeta_toxin PF06414.12 CCF42112.1 - 0.035 13.4 0.1 0.08 12.2 0.0 1.6 2 0 0 2 2 2 0 Zeta toxin TOM6p PF15184.6 CCF42112.1 - 0.038 13.8 0.1 0.083 12.7 0.1 1.5 1 0 0 1 1 1 0 Mitochondrial import receptor subunit TOM6 homolog AAA_17 PF13207.6 CCF42112.1 - 0.043 14.2 0.1 0.16 12.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 CCF42112.1 - 0.047 12.9 0.0 0.12 11.5 0.0 1.7 1 1 0 1 1 1 0 NB-ARC domain AAA_7 PF12775.7 CCF42112.1 - 0.051 13.1 0.0 0.096 12.2 0.0 1.5 1 1 0 1 1 1 0 P-loop containing dynein motor region TsaE PF02367.17 CCF42112.1 - 0.054 13.5 0.0 0.096 12.7 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activ_2 PF14532.6 CCF42112.1 - 0.075 13.1 0.0 0.18 11.9 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain ABC_tran PF00005.27 CCF42112.1 - 0.078 13.5 0.0 0.14 12.7 0.0 1.5 1 0 0 1 1 1 0 ABC transporter Guanylate_kin PF00625.21 CCF42112.1 - 0.092 12.4 0.0 0.88 9.2 0.0 2.4 2 1 1 3 3 3 0 Guanylate kinase Viral_helicase1 PF01443.18 CCF42112.1 - 0.13 12.0 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Hydantoinase_B PF02538.14 CCF42115.1 - 3.9e-58 197.1 10.1 4.5e-58 196.9 10.1 1.0 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Fic PF02661.18 CCF42116.1 - 9e-16 58.6 0.0 2.1e-15 57.4 0.0 1.7 1 0 0 1 1 1 1 Fic/DOC family PV-1 PF06637.11 CCF42116.1 - 0.05 12.4 0.0 0.086 11.6 0.0 1.3 1 0 0 1 1 1 0 PV-1 protein (PLVAP) NmrA PF05368.13 CCF42117.1 - 5.9e-12 45.6 0.0 8.1e-12 45.2 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CCF42117.1 - 3.9e-08 33.4 0.0 6.2e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Tyrosinase PF00264.20 CCF42120.1 - 2.7e-05 24.6 0.0 3.3e-05 24.3 0.0 1.0 1 0 0 1 1 1 1 Common central domain of tyrosinase Glyco_hydro_61 PF03443.14 CCF42122.1 - 4.3e-63 213.0 0.2 5.8e-63 212.6 0.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 LRR_RI_capping PF18779.1 CCF42123.1 - 0.039 13.6 0.9 0.16 11.7 0.3 2.1 2 0 0 2 2 2 0 Capping Ribonuclease inhibitor Leucine Rich Repeat Peptidase_C14 PF00656.22 CCF42124.1 - 1.8e-44 152.6 0.0 2.1e-44 152.3 0.0 1.1 1 0 0 1 1 1 1 Caspase domain CDC45 PF02724.14 CCF42126.1 - 2.1e-181 604.5 2.7 4.9e-181 603.3 2.7 2.0 1 1 0 1 1 1 1 CDC45-like protein Amidase PF01425.21 CCF42127.1 - 2.1e-59 201.7 0.1 2.5e-59 201.4 0.1 1.0 1 0 0 1 1 1 1 Amidase Transp_cyt_pur PF02133.15 CCF42128.1 - 9.4e-52 176.3 14.6 1.1e-51 176.0 14.6 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin DHDPS PF00701.22 CCF42130.1 - 2.3e-35 121.7 0.0 3.1e-35 121.3 0.0 1.1 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family Toxin_ToxA PF11584.8 CCF42130.1 - 0.061 13.3 0.1 0.23 11.5 0.0 2.0 2 1 1 3 3 3 0 Proteinaceous host-selective toxin ToxA TusA PF01206.17 CCF42131.1 - 0.17 11.7 0.0 0.34 10.8 0.0 1.5 1 0 0 1 1 1 0 Sulfurtransferase TusA AFG1_ATPase PF03969.16 CCF42132.1 - 2.3e-54 184.7 0.1 1.1e-26 93.6 0.0 4.6 3 2 0 4 4 4 3 AFG1-like ATPase AAA_16 PF13191.6 CCF42132.1 - 4.5e-06 27.1 0.8 0.0031 17.9 0.3 3.4 1 1 1 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 CCF42132.1 - 0.00042 20.3 0.0 0.001 19.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 CCF42132.1 - 0.004 17.4 0.0 0.013 15.8 0.0 1.9 1 1 0 1 1 1 1 AAA domain NACHT PF05729.12 CCF42132.1 - 0.0092 15.9 0.0 0.11 12.4 0.0 2.3 2 0 0 2 2 2 1 NACHT domain AAA PF00004.29 CCF42132.1 - 0.021 15.3 0.0 0.043 14.2 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 CCF42132.1 - 0.021 15.3 0.1 3.8 8.0 0.1 2.4 1 1 1 2 2 2 0 ABC transporter Bac_DnaA PF00308.18 CCF42132.1 - 0.035 13.9 0.0 0.52 10.1 0.0 2.4 2 1 0 2 2 2 0 Bacterial dnaA protein AAA_14 PF13173.6 CCF42132.1 - 0.05 13.6 0.0 0.1 12.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 CCF42132.1 - 0.054 13.2 0.0 0.13 12.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain TsaE PF02367.17 CCF42132.1 - 0.15 12.1 0.0 0.3 11.1 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RTA1 PF04479.13 CCF42133.1 - 5.2e-17 62.2 0.9 5.2e-17 62.2 0.9 1.4 2 0 0 2 2 2 1 RTA1 like protein Amidase02_C PF12123.8 CCF42134.1 - 0.00073 19.2 0.1 0.0012 18.5 0.1 1.4 1 0 0 1 1 1 1 N-acetylmuramoyl-l-alanine amidase AA_permease_N PF08403.10 CCF42134.1 - 0.023 14.2 0.2 5.5 6.6 0.0 2.3 2 0 0 2 2 2 0 Amino acid permease N-terminal Esterase_phd PF10503.9 CCF42136.1 - 3.6e-22 79.0 0.9 6e-22 78.2 0.9 1.3 1 0 0 1 1 1 1 Esterase PHB depolymerase Peptidase_S9 PF00326.21 CCF42136.1 - 1.8e-09 37.4 0.6 2.7e-09 36.8 0.6 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 CCF42136.1 - 0.046 13.6 0.0 0.065 13.1 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold COesterase PF00135.28 CCF42136.1 - 0.099 11.5 1.1 0.33 9.8 0.1 1.9 2 0 0 2 2 2 0 Carboxylesterase family adh_short PF00106.25 CCF42137.1 - 4.6e-37 127.4 0.7 7.6e-37 126.7 0.7 1.4 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF42137.1 - 1.5e-27 96.7 0.1 2e-27 96.3 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF42137.1 - 1.5e-09 38.0 5.9 2.2e-08 34.2 5.9 2.1 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF42137.1 - 2.7e-06 27.0 1.1 3.2e-06 26.8 0.2 1.6 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CCF42137.1 - 0.00012 22.0 0.3 0.00017 21.5 0.3 1.4 1 1 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 CCF42137.1 - 0.00012 21.6 0.6 0.00024 20.6 0.2 1.6 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 CCF42137.1 - 0.0002 20.5 0.2 0.00029 19.9 0.2 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 CCF42137.1 - 0.0043 16.2 0.0 0.0068 15.5 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain TrkA_N PF02254.18 CCF42137.1 - 0.059 13.6 0.2 0.11 12.8 0.2 1.4 1 0 0 1 1 1 0 TrkA-N domain 3HCDH_N PF02737.18 CCF42137.1 - 0.082 12.8 0.1 0.14 12.0 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NmrA PF05368.13 CCF42137.1 - 0.087 12.4 0.4 0.15 11.6 0.4 1.4 1 0 0 1 1 1 0 NmrA-like family Methyltransf_23 PF13489.6 CCF42138.1 - 6.1e-19 68.5 0.0 8e-19 68.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF42138.1 - 6.2e-12 46.1 0.0 1.6e-11 44.7 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF42138.1 - 1e-10 42.1 0.0 1.6e-10 41.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF42138.1 - 4.2e-10 39.6 0.0 3.3e-09 36.7 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF42138.1 - 2.1e-09 38.0 0.0 1e-08 35.8 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 CCF42138.1 - 0.0011 18.3 0.0 0.0017 17.7 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain FtsJ PF01728.19 CCF42138.1 - 0.0059 16.7 0.0 0.0078 16.3 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_4 PF02390.17 CCF42138.1 - 0.0079 15.7 0.0 0.026 14.0 0.0 1.7 2 0 0 2 2 2 1 Putative methyltransferase CheR PF01739.18 CCF42138.1 - 0.019 14.4 0.0 0.043 13.3 0.0 1.5 2 0 0 2 2 2 0 CheR methyltransferase, SAM binding domain MTS PF05175.14 CCF42138.1 - 0.042 13.4 0.0 0.072 12.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Ubie_methyltran PF01209.18 CCF42138.1 - 0.063 12.6 0.0 0.3 10.4 0.0 1.9 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family PrmA PF06325.13 CCF42138.1 - 0.15 11.4 0.0 0.24 10.7 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) EXS PF03124.14 CCF42140.1 - 6.8e-113 377.3 10.7 7.7e-113 377.2 10.7 1.0 1 0 0 1 1 1 1 EXS family DAO PF01266.24 CCF42142.1 - 4.2e-44 151.6 0.0 5.2e-44 151.2 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CCF42142.1 - 3e-08 33.2 2.8 0.003 16.7 1.2 2.1 2 0 0 2 2 2 2 FAD binding domain FAD_oxidored PF12831.7 CCF42142.1 - 1.6e-06 27.7 0.2 0.00019 20.9 0.1 2.1 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCF42142.1 - 0.00022 20.5 0.4 0.00075 18.8 0.4 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CCF42142.1 - 0.0028 16.8 0.1 0.11 11.6 0.1 2.1 2 0 0 2 2 2 1 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 CCF42142.1 - 0.015 14.6 0.0 0.071 12.3 0.0 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 CCF42142.1 - 0.018 15.0 0.0 0.029 14.3 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox PF00070.27 CCF42142.1 - 0.03 14.9 0.6 0.27 11.8 0.1 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCF42142.1 - 0.034 14.4 0.2 0.15 12.4 0.2 2.0 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 CCF42142.1 - 0.048 12.4 0.2 0.069 11.8 0.2 1.2 1 0 0 1 1 1 0 HI0933-like protein Thi4 PF01946.17 CCF42142.1 - 0.12 11.6 0.3 1.3 8.2 0.0 2.4 3 0 0 3 3 3 0 Thi4 family Alpha-amylase PF00128.24 CCF42143.1 - 2.1e-108 362.9 0.0 2.9e-108 362.4 0.0 1.2 1 0 0 1 1 1 1 Alpha amylase, catalytic domain hDGE_amylase PF14701.6 CCF42143.1 - 0.071 12.2 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain CRC_subunit PF08624.10 CCF42144.1 - 1.4e-53 181.0 0.0 2.2e-53 180.3 0.0 1.3 1 0 0 1 1 1 1 Chromatin remodelling complex Rsc7/Swp82 subunit SDA1 PF05285.12 CCF42144.1 - 0.52 9.7 10.9 0.82 9.0 10.9 1.3 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 CCF42144.1 - 0.76 8.0 8.1 1 7.5 8.1 1.1 1 0 0 1 1 1 0 CDC45-like protein DNA_pol_phi PF04931.13 CCF42144.1 - 1.7 6.7 12.6 2.1 6.4 12.6 1.1 1 0 0 1 1 1 0 DNA polymerase phi Nop14 PF04147.12 CCF42144.1 - 2.3 6.3 13.0 3.3 5.8 13.0 1.1 1 0 0 1 1 1 0 Nop14-like family Vfa1 PF08432.10 CCF42144.1 - 3.4 8.0 8.9 37 4.6 0.0 2.3 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Abhydrolase_1 PF00561.20 CCF42145.1 - 1.1e-13 51.5 0.1 1.6e-13 50.9 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CCF42145.1 - 1.6e-11 43.9 0.0 2.8e-11 43.2 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CCF42145.1 - 5.1e-07 30.5 5.5 5.1e-07 30.5 5.5 2.0 2 0 0 2 2 2 1 Alpha/beta hydrolase family Thioesterase PF00975.20 CCF42145.1 - 0.026 14.7 0.1 0.036 14.2 0.1 1.3 1 0 0 1 1 1 0 Thioesterase domain Abhydrolase_5 PF12695.7 CCF42145.1 - 0.12 12.1 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family PNP_phzG_C PF10590.9 CCF42146.1 - 1e-22 79.9 1.7 1.2e-22 79.7 1.7 1.1 1 0 0 1 1 1 1 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region DUF3833 PF12915.7 CCF42146.1 - 0.13 11.8 0.2 0.15 11.6 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3833) Cyclin_N PF00134.23 CCF42147.1 - 1.1e-05 25.2 0.2 8.8e-05 22.2 0.1 2.1 1 1 0 2 2 2 1 Cyclin, N-terminal domain Abhydrolase_1 PF00561.20 CCF42149.1 - 1.1e-16 61.2 0.1 5.8e-16 58.9 0.1 1.9 1 1 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCF42149.1 - 4e-14 53.8 0.0 6e-14 53.2 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCF42149.1 - 6.2e-12 45.3 0.0 1e-11 44.6 0.0 1.6 1 1 0 1 1 1 1 Serine aminopeptidase, S33 BAAT_C PF08840.11 CCF42149.1 - 0.065 13.2 0.0 0.64 9.9 0.0 2.0 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Mcl1_mid PF12341.8 CCF42150.1 - 7e-99 330.9 0.0 1.2e-97 326.9 0.0 2.4 3 0 0 3 3 3 1 Minichromosome loss protein, Mcl1, middle region WD40 PF00400.32 CCF42150.1 - 2.9e-21 75.4 0.2 3.7e-07 30.7 0.0 7.3 8 0 0 8 8 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF42150.1 - 8.2e-21 74.1 0.0 2.4e-05 24.5 0.1 7.4 2 1 6 8 8 8 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CCF42150.1 - 0.00077 19.4 0.0 0.0043 17.0 0.0 2.2 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A Coatomer_WDAD PF04053.14 CCF42150.1 - 0.00098 18.3 0.0 0.0029 16.7 0.0 1.6 1 1 1 2 2 2 1 Coatomer WD associated region Ge1_WD40 PF16529.5 CCF42150.1 - 0.0035 16.4 0.0 2.2 7.2 0.0 2.8 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein IKI3 PF04762.12 CCF42150.1 - 0.029 12.4 0.1 0.07 11.1 0.0 1.6 2 0 0 2 2 2 0 IKI3 family MMS1_N PF10433.9 CCF42150.1 - 0.047 12.3 0.0 2.9 6.4 0.0 2.9 1 1 0 3 3 3 0 Mono-functional DNA-alkylating methyl methanesulfonate N-term WD40_3 PF15911.5 CCF42150.1 - 0.081 12.9 0.1 1.6 8.8 0.0 2.9 3 0 0 3 3 3 0 WD domain, G-beta repeat DNA_pol_alpha_N PF12254.8 CCF42150.1 - 0.52 10.4 5.1 1.4 9.1 5.1 1.7 1 0 0 1 1 1 0 DNA polymerase alpha subunit p180 N terminal PQQ_3 PF13570.6 CCF42150.1 - 0.83 10.2 8.3 8.9 7.0 0.0 5.0 5 1 0 5 5 5 0 PQQ-like domain WD40 PF00400.32 CCF42151.1 - 2.6e-12 47.0 8.9 0.0038 18.0 0.0 6.1 6 0 0 6 6 6 3 WD domain, G-beta repeat PQQ_3 PF13570.6 CCF42151.1 - 0.11 13.0 2.5 0.4 11.2 0.1 3.1 4 0 0 4 4 4 0 PQQ-like domain DUF3774 PF12609.8 CCF42151.1 - 0.13 13.3 0.4 3.1 8.9 0.0 2.5 2 0 0 2 2 2 0 Wound-induced protein Chitin_bind_1 PF00187.19 CCF42152.1 - 4.4e-07 30.3 20.1 8.7e-07 29.3 20.1 1.6 1 0 0 1 1 1 1 Chitin recognition protein adh_short PF00106.25 CCF42153.1 - 9.7e-38 129.6 1.2 1.1e-37 129.4 1.2 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF42153.1 - 4.6e-31 108.2 0.7 5.5e-31 107.9 0.7 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF42153.1 - 1.7e-11 44.4 0.2 2e-11 44.2 0.2 1.0 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF42153.1 - 0.0017 17.8 0.2 0.0023 17.4 0.2 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Cas_Cas02710 PF09670.10 CCF42153.1 - 0.0018 17.2 0.3 0.0021 16.9 0.3 1.1 1 0 0 1 1 1 1 CRISPR-associated protein (Cas_Cas02710) THF_DHG_CYH_C PF02882.19 CCF42153.1 - 0.0022 17.3 0.4 0.0041 16.5 0.1 1.6 1 1 1 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DUF1776 PF08643.10 CCF42153.1 - 0.0054 16.1 0.1 0.02 14.3 0.1 1.8 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) NAD_binding_10 PF13460.6 CCF42153.1 - 0.0084 16.0 0.3 0.011 15.7 0.3 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Pyr_redox_3 PF13738.6 CCF42153.1 - 0.017 14.4 0.4 0.021 14.1 0.4 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 CCF42153.1 - 0.024 14.5 1.3 0.035 14.0 1.3 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain YjeF_N PF03853.15 CCF42153.1 - 0.052 13.4 0.1 0.063 13.2 0.1 1.2 1 0 0 1 1 1 0 YjeF-related protein N-terminus CbiJ PF02571.14 CCF42153.1 - 0.054 13.0 0.7 0.071 12.6 0.7 1.2 1 0 0 1 1 1 0 Precorrin-6x reductase CbiJ/CobK DFP PF04127.15 CCF42153.1 - 0.062 13.1 2.6 0.14 12.0 2.6 1.6 1 1 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein SIR2 PF02146.17 CCF42153.1 - 0.15 11.9 0.0 0.2 11.5 0.0 1.2 1 0 0 1 1 1 0 Sir2 family ketoacyl-synt PF00109.26 CCF42155.1 - 2.3e-33 115.9 0.0 3.2e-33 115.4 0.0 1.2 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 CCF42156.1 - 5.4e-43 145.8 0.0 7.5e-43 145.3 0.0 1.2 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 CCF42156.1 - 4.7e-17 62.5 0.1 9.2e-17 61.5 0.1 1.5 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Acyl_transf_1 PF00698.21 CCF42156.1 - 1.3e-10 41.4 0.1 2.2e-10 40.5 0.1 1.4 1 0 0 1 1 1 1 Acyl transferase domain ketoacyl-synt PF00109.26 CCF42156.1 - 9.4e-07 28.7 0.1 2.1e-06 27.5 0.0 1.6 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain ERG2_Sigma1R PF04622.12 CCF42157.1 - 1.2e-97 325.3 0.2 1.4e-97 325.1 0.2 1.0 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein UCR_6-4kD PF08997.10 CCF42157.1 - 0.0056 16.6 0.2 0.99 9.4 0.0 2.6 2 0 0 2 2 2 2 Ubiquinol-cytochrome C reductase complex, 6.4kD protein Chordopox_A20R PF05941.13 CCF42157.1 - 0.087 11.8 0.0 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 Chordopoxvirus A20R protein ECH_1 PF00378.20 CCF42159.1 - 4.2e-33 114.7 0.0 2.4e-30 105.7 0.0 2.5 2 1 0 2 2 2 2 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CCF42159.1 - 6.5e-20 71.9 0.0 4.3e-15 56.0 0.0 2.3 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase Glyco_trans_4_4 PF13579.6 CCF42159.1 - 0.00035 21.1 0.0 0.037 14.5 0.1 2.5 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain eIF2A PF08662.11 CCF42160.1 - 1.6e-39 135.8 1.8 1.5e-34 119.6 0.3 3.5 2 2 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A RRM_1 PF00076.22 CCF42160.1 - 0.00041 20.1 0.0 0.00081 19.2 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WD40 PF00400.32 CCF42160.1 - 0.01 16.7 3.0 6.2 7.9 0.0 4.5 4 0 0 4 4 4 1 WD domain, G-beta repeat PRP3 PF08572.10 CCF42160.1 - 0.038 13.7 0.0 0.065 13.0 0.0 1.4 1 0 0 1 1 1 0 pre-mRNA processing factor 3 (PRP3) BofC_C PF08955.10 CCF42160.1 - 0.079 13.0 0.1 12 6.0 0.0 3.4 3 0 0 3 3 3 0 BofC C-terminal domain CCDC92 PF14916.6 CCF42161.1 - 0.026 14.3 0.2 0.066 13.0 0.2 1.7 1 0 0 1 1 1 0 Coiled-coil domain of unknown function DUF4875 PF16175.5 CCF42162.1 - 0.17 12.1 0.0 0.17 12.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4875) Stn1 PF10451.9 CCF42163.1 - 2.6e-11 43.0 0.3 2.9e-05 23.2 0.1 2.0 2 0 0 2 2 2 2 Telomere regulation protein Stn1 Acyl_transf_1 PF00698.21 CCF42165.1 - 1.4e-31 110.2 0.5 2.8e-31 109.2 0.5 1.5 1 0 0 1 1 1 1 Acyl transferase domain PS-DH PF14765.6 CCF42165.1 - 1.4e-13 50.7 0.0 2.6e-13 49.9 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase PP-binding PF00550.25 CCF42165.1 - 4e-08 33.5 0.3 8.8e-08 32.4 0.3 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site DUF915 PF06028.11 CCF42165.1 - 0.023 14.0 0.0 4.6 6.5 0.0 2.2 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) FHA PF00498.26 CCF42166.1 - 3.8e-15 56.0 0.0 7.3e-15 55.1 0.0 1.5 1 0 0 1 1 1 1 FHA domain zf-RING_11 PF17123.5 CCF42166.1 - 7.5e-13 48.0 10.4 1.3e-12 47.2 10.4 1.4 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_2 PF13639.6 CCF42166.1 - 2.2e-06 27.9 13.0 3.6e-06 27.2 13.0 1.4 1 0 0 1 1 1 1 Ring finger domain Yop-YscD_cpl PF16697.5 CCF42166.1 - 0.0092 16.3 0.0 0.023 15.0 0.0 1.6 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain zf-rbx1 PF12678.7 CCF42166.1 - 0.01 16.1 8.7 0.027 14.7 8.7 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 CCF42166.1 - 0.013 15.3 12.8 0.023 14.6 12.8 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CCF42166.1 - 0.15 12.0 10.3 0.26 11.3 10.3 1.4 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_2 PF13923.6 CCF42166.1 - 0.2 11.5 11.9 0.36 10.7 11.9 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 CCF42166.1 - 0.21 11.7 3.3 0.41 10.7 3.3 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger lci PF12197.8 CCF42166.1 - 0.23 11.3 2.9 0.2 11.5 1.1 1.8 2 0 0 2 2 2 0 Bacillus cereus group antimicrobial protein zf-RING_UBOX PF13445.6 CCF42166.1 - 0.37 10.8 11.8 0.85 9.7 11.8 1.7 1 0 0 1 1 1 0 RING-type zinc-finger Mt_ATP-synt_D PF05873.12 CCF42167.1 - 8.3e-23 80.9 1.4 9.9e-23 80.7 1.4 1.1 1 0 0 1 1 1 1 ATP synthase D chain, mitochondrial (ATP5H) T5orf172 PF10544.9 CCF42167.1 - 0.11 13.0 0.1 0.22 12.1 0.1 1.6 1 1 0 1 1 1 0 T5orf172 domain Abhydrolase_3 PF07859.13 CCF42168.1 - 4e-33 115.1 0.1 5.9e-33 114.5 0.1 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CCF42168.1 - 1.5e-05 24.4 0.0 2.2e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CCF42168.1 - 0.00018 22.2 4.6 0.00018 22.2 4.6 1.6 2 0 0 2 2 2 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 CCF42168.1 - 0.051 13.0 0.2 0.11 11.9 0.0 1.6 2 0 0 2 2 2 0 Prolyl oligopeptidase family Say1_Mug180 PF10340.9 CCF42168.1 - 0.051 12.4 0.0 0.072 11.9 0.0 1.1 1 0 0 1 1 1 0 Steryl acetyl hydrolase Pkinase PF00069.25 CCF42169.1 - 1.1e-39 136.4 0.0 2.1e-37 128.9 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCF42169.1 - 3e-22 79.2 0.0 5.3e-22 78.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Exostosin PF03016.15 CCF42169.1 - 0.06 12.5 0.0 0.1 11.8 0.0 1.3 1 0 0 1 1 1 0 Exostosin family Alpha_L_fucos PF01120.17 CCF42172.1 - 2.3e-88 297.0 1.1 3.1e-88 296.6 1.1 1.1 1 0 0 1 1 1 1 Alpha-L-fucosidase GHL6 PF14871.6 CCF42172.1 - 0.071 13.2 0.0 0.17 12.0 0.0 1.7 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase 6 RdRP PF05183.12 CCF42174.1 - 4.9e-178 593.4 0.0 7.1e-178 592.9 0.0 1.2 1 0 0 1 1 1 1 RNA dependent RNA polymerase RRM_1 PF00076.22 CCF42174.1 - 0.00014 21.6 0.0 0.0019 17.9 0.0 2.6 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FAD-oxidase_C PF02913.19 CCF42175.1 - 1.3e-62 211.7 0.0 1.9e-62 211.2 0.0 1.3 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 CCF42175.1 - 6.1e-34 116.7 0.1 1.7e-33 115.3 0.0 1.8 2 0 0 2 2 2 1 FAD binding domain SepSecS PF05889.13 CCF42175.1 - 0.072 11.8 0.0 0.12 11.1 0.0 1.3 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS LysM PF01476.20 CCF42176.1 - 0.029 14.4 0.0 0.04 14.0 0.0 1.2 1 0 0 1 1 1 0 LysM domain Med3 PF11593.8 CCF42176.1 - 0.047 12.9 0.3 0.049 12.8 0.3 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Sporozoite_P67 PF05642.11 CCF42176.1 - 1.3 7.0 7.7 1.5 6.8 7.7 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF2890 PF11081.8 CCF42177.1 - 0.041 14.0 0.5 0.075 13.1 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) Rox3 PF08633.10 CCF42178.1 - 0.0063 16.8 13.0 0.008 16.5 13.0 1.2 1 0 0 1 1 1 1 Rox3 mediator complex subunit Draxin PF15550.6 CCF42178.1 - 0.62 9.9 19.1 0.79 9.5 19.1 1.0 1 0 0 1 1 1 0 Draxin AP3D1 PF06375.11 CCF42178.1 - 3.8 7.7 17.2 6.3 7.0 17.2 1.4 1 1 0 1 1 1 0 AP-3 complex subunit delta-1 Peptidase_S8 PF00082.22 CCF42179.1 - 1.1e-10 41.3 3.2 1.6e-08 34.1 3.2 2.7 1 1 0 1 1 1 1 Subtilase family HypD PF01924.16 CCF42179.1 - 0.016 14.3 0.1 0.025 13.7 0.1 1.2 1 0 0 1 1 1 0 Hydrogenase formation hypA family Phage_sheath_1 PF04984.14 CCF42179.1 - 0.068 13.0 0.3 0.12 12.2 0.3 1.3 1 0 0 1 1 1 0 Phage tail sheath protein subtilisin-like domain UPF0254 PF06787.11 CCF42180.1 - 0.098 12.4 0.0 0.26 11.0 0.0 1.6 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0254) Ank_5 PF13857.6 CCF42181.1 - 4.2e-19 68.4 4.7 7.8e-06 26.1 0.1 4.5 4 0 0 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 CCF42181.1 - 1.8e-16 60.3 7.1 2.3e-05 24.9 0.0 4.8 4 1 1 5 5 5 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 CCF42181.1 - 7.9e-15 55.2 0.6 3.8e-06 27.4 0.0 3.3 2 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CCF42181.1 - 9.5e-14 50.2 3.0 0.0035 17.7 0.0 5.2 4 0 0 4 4 4 4 Ankyrin repeat Ank PF00023.30 CCF42181.1 - 2.3e-08 34.1 12.3 0.074 13.5 0.0 5.2 5 0 0 5 5 5 3 Ankyrin repeat F-box-like PF12937.7 CCF42181.1 - 0.00012 21.9 0.9 0.00046 20.0 0.9 1.9 1 1 0 1 1 1 1 F-box-like Sec62 PF03839.16 CCF42183.1 - 2.1e-70 236.6 1.5 2.1e-70 236.6 1.5 1.4 2 0 0 2 2 2 1 Translocation protein Sec62 Corona_M PF01635.18 CCF42183.1 - 0.75 9.1 6.9 1.1 8.5 6.9 1.2 1 0 0 1 1 1 0 Coronavirus M matrix/glycoprotein SelP_N PF04592.14 CCF42183.1 - 2.7 7.3 7.6 5.4 6.3 7.6 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Bac_rhamnosid_N PF08531.10 CCF42184.1 - 0.053 13.4 0.0 0.057 13.2 0.0 1.0 1 0 0 1 1 1 0 Alpha-L-rhamnosidase N-terminal domain PTPS_related PF10131.9 CCF42185.1 - 0.0053 15.1 0.4 0.0061 14.9 0.4 1.0 1 0 0 1 1 1 1 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein NAD_Gly3P_dh_N PF01210.23 CCF42186.1 - 1.4e-46 158.3 0.0 1.2e-45 155.3 0.0 2.0 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.14 CCF42186.1 - 2.2e-42 144.7 0.1 3.7e-42 144.0 0.1 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus ABC_membrane PF00664.23 CCF42187.1 - 3.4e-84 282.7 32.8 4.7e-42 144.5 13.8 2.4 2 1 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 CCF42187.1 - 2.6e-70 235.3 0.0 1.1e-33 116.7 0.0 2.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 CCF42187.1 - 5.5e-14 52.1 0.1 1.4e-05 24.6 0.0 4.0 3 1 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CCF42187.1 - 3e-08 33.3 0.7 0.0039 16.9 0.3 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 CCF42187.1 - 2.3e-07 31.2 0.1 0.084 13.1 0.0 3.7 2 2 0 2 2 2 2 AAA domain AAA_16 PF13191.6 CCF42187.1 - 3e-07 31.0 2.5 0.00093 19.6 0.1 2.9 2 1 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 CCF42187.1 - 4.8e-07 29.8 0.0 0.032 14.1 0.0 2.7 2 0 0 2 2 2 2 RsgA GTPase Zeta_toxin PF06414.12 CCF42187.1 - 3.9e-06 26.3 0.0 0.079 12.2 0.0 3.0 3 0 0 3 3 3 2 Zeta toxin ABC_ATPase PF09818.9 CCF42187.1 - 7.2e-06 25.1 0.1 0.18 10.6 0.0 3.5 4 0 0 4 4 4 2 Predicted ATPase of the ABC class AAA_15 PF13175.6 CCF42187.1 - 7.7e-06 25.9 0.0 0.038 13.7 0.0 2.3 2 0 0 2 2 2 2 AAA ATPase domain AAA_25 PF13481.6 CCF42187.1 - 1.4e-05 24.7 0.5 0.27 10.8 0.0 3.0 2 1 0 2 2 2 2 AAA domain AAA_21 PF13304.6 CCF42187.1 - 2.6e-05 24.2 0.1 0.29 10.9 0.1 3.9 4 0 0 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_30 PF13604.6 CCF42187.1 - 0.00052 19.8 0.8 1.4 8.6 0.2 3.3 4 0 0 4 4 3 2 AAA domain AAA_28 PF13521.6 CCF42187.1 - 0.00078 19.7 0.0 0.66 10.2 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.6 CCF42187.1 - 0.0016 19.0 0.4 0.63 10.5 0.1 2.7 3 0 0 3 3 2 1 AAA domain AAA_33 PF13671.6 CCF42187.1 - 0.003 17.7 0.0 3.4 7.8 0.0 2.4 2 0 0 2 2 2 2 AAA domain DUF87 PF01935.17 CCF42187.1 - 0.0044 17.2 0.3 2.7 8.0 0.0 2.8 3 0 0 3 3 2 1 Helicase HerA, central domain MMR_HSR1 PF01926.23 CCF42187.1 - 0.0047 17.0 0.0 1.6 8.8 0.0 3.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_18 PF13238.6 CCF42187.1 - 0.006 17.1 0.0 5.1 7.6 0.0 2.6 2 0 0 2 2 2 1 AAA domain SbcCD_C PF13558.6 CCF42187.1 - 0.0085 16.3 1.6 8.5 6.7 0.1 3.7 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit G-alpha PF00503.20 CCF42187.1 - 0.009 15.2 0.1 2 7.5 0.0 2.3 2 0 0 2 2 2 1 G-protein alpha subunit AAA_7 PF12775.7 CCF42187.1 - 0.0099 15.4 0.0 2.1 7.8 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_5 PF07728.14 CCF42187.1 - 0.012 15.6 0.1 16 5.5 0.0 3.5 4 0 0 4 4 3 0 AAA domain (dynein-related subfamily) AAA PF00004.29 CCF42187.1 - 0.013 15.9 0.5 20 5.6 0.0 4.3 5 0 0 5 5 4 0 ATPase family associated with various cellular activities (AAA) APS_kinase PF01583.20 CCF42187.1 - 0.026 14.4 0.1 3.4 7.5 0.1 3.3 4 0 0 4 4 3 0 Adenylylsulphate kinase Rad17 PF03215.15 CCF42187.1 - 0.054 13.4 0.0 1.2 9.0 0.0 2.3 2 0 0 2 2 2 0 Rad17 P-loop domain NB-ARC PF00931.22 CCF42187.1 - 0.06 12.5 0.1 3 6.9 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain RNA_helicase PF00910.22 CCF42187.1 - 0.085 13.2 0.1 4.3 7.8 0.0 2.5 2 0 0 2 2 2 0 RNA helicase SRP54 PF00448.22 CCF42187.1 - 0.094 12.3 0.0 11 5.6 0.1 2.5 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain Ploopntkinase3 PF18751.1 CCF42187.1 - 0.12 12.3 0.1 22 4.9 0.0 2.6 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 DUF5056 PF16479.5 CCF42187.1 - 0.13 12.5 0.3 0.53 10.6 0.3 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5056) RNase_PH PF01138.21 CCF42188.1 - 8.4e-17 61.9 0.0 2.8e-16 60.2 0.0 1.9 2 1 0 2 2 2 1 3' exoribonuclease family, domain 1 CHORD PF04968.12 CCF42189.1 - 0.043 14.5 4.7 0.39 11.5 0.7 2.8 2 1 0 2 2 2 0 CHORD SapB_1 PF05184.15 CCF42189.1 - 0.27 11.3 2.6 29 4.8 0.0 3.2 3 0 0 3 3 3 0 Saposin-like type B, region 1 BTK PF00779.19 CCF42189.1 - 1.4 8.8 5.4 6.4 6.7 2.4 2.6 2 0 0 2 2 2 0 BTK motif GDI PF00996.18 CCF42190.1 - 9.4e-26 90.3 0.0 1e-23 83.6 0.0 2.0 1 1 0 1 1 1 1 GDP dissociation inhibitor YukD PF08817.10 CCF42193.1 - 0.14 12.8 0.1 2.3 9.0 0.0 2.5 1 1 1 2 2 2 0 WXG100 protein secretion system (Wss), protein YukD AAA_14 PF13173.6 CCF42194.1 - 0.22 11.6 0.0 0.33 11.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain DUF3074 PF11274.8 CCF42195.1 - 3.3e-61 206.5 1.3 5.4e-60 202.5 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF3074) Caldesmon PF02029.15 CCF42195.1 - 0.0083 14.9 30.1 0.021 13.6 30.1 1.6 1 1 0 1 1 1 1 Caldesmon Exonuc_VII_L PF02601.15 CCF42195.1 - 0.25 10.9 12.7 0.4 10.2 12.7 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Spc7 PF08317.11 CCF42195.1 - 0.51 9.2 26.7 1.2 7.9 26.7 1.6 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF4207 PF13904.6 CCF42195.1 - 1.3 8.7 30.7 2.5 7.8 25.6 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4207) FapA PF03961.13 CCF42195.1 - 3.7 6.0 14.9 7.1 5.1 14.9 1.4 1 0 0 1 1 1 0 Flagellar Assembly Protein A AAA_23 PF13476.6 CCF42195.1 - 9.6 6.6 19.6 17 5.9 18.7 1.9 2 0 0 2 2 2 0 AAA domain PAN_1 PF00024.26 CCF42197.1 - 1.7e-05 24.7 0.4 2.6e-05 24.1 0.4 1.3 1 0 0 1 1 1 1 PAN domain PAN_4 PF14295.6 CCF42197.1 - 0.013 15.4 0.9 0.029 14.3 0.9 1.6 1 0 0 1 1 1 0 PAN domain NAP PF00956.18 CCF42198.1 - 3.7e-101 337.8 11.7 5.9e-101 337.2 11.7 1.3 1 0 0 1 1 1 1 Nucleosome assembly protein (NAP) Striatin PF08232.12 CCF42198.1 - 0.012 16.3 2.6 0.012 16.3 2.6 2.4 2 1 0 2 2 2 0 Striatin family RNA_pol_3_Rpc31 PF11705.8 CCF42198.1 - 9.6 6.4 33.0 5.7 7.1 18.8 2.4 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 SKG6 PF08693.10 CCF42199.1 - 0.034 13.5 0.1 0.083 12.3 0.1 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Adeno_E3_CR2 PF02439.15 CCF42199.1 - 0.14 12.0 0.3 0.26 11.1 0.3 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 OPT PF03169.15 CCF42200.1 - 1.5e-164 549.0 55.6 1.8e-164 548.8 55.6 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Ammonium_transp PF00909.21 CCF42201.1 - 6.3e-117 390.6 26.6 7.2e-117 390.4 26.6 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family CoA_binding PF02629.19 CCF42203.1 - 7.1e-29 100.3 3.3 9.9e-29 99.9 1.1 2.1 2 0 0 2 2 2 1 CoA binding domain Ligase_CoA PF00549.19 CCF42203.1 - 1.8e-23 83.0 0.3 3.1e-23 82.3 0.3 1.4 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.6 CCF42203.1 - 1.3e-09 38.0 0.0 2.2e-09 37.2 0.0 1.4 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 CCF42203.1 - 8.1e-06 26.3 0.1 4.9e-05 23.8 0.0 2.3 3 0 0 3 3 3 1 CoA binding domain GFO_IDH_MocA PF01408.22 CCF42203.1 - 0.052 14.4 0.1 0.18 12.7 0.0 1.9 2 0 0 2 2 2 0 Oxidoreductase family, NAD-binding Rossmann fold Asp PF00026.23 CCF42205.1 - 2e-36 126.0 0.0 1e-26 94.1 0.6 2.1 2 0 0 2 2 2 2 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCF42205.1 - 0.0015 18.8 0.4 0.0087 16.3 0.4 2.2 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 CCF42205.1 - 0.047 14.3 0.4 15 6.3 0.1 3.3 2 1 0 2 2 2 0 Aspartyl protease Ank_2 PF12796.7 CCF42206.1 - 8.4e-39 132.0 0.7 1.6e-15 57.4 0.0 4.0 2 1 0 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CCF42206.1 - 9.6e-32 108.6 4.1 2e-07 31.1 0.0 7.6 3 2 5 8 8 8 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCF42206.1 - 2.5e-30 101.1 0.6 5.3e-06 26.4 0.0 8.4 8 0 0 8 8 8 7 Ankyrin repeat Ank PF00023.30 CCF42206.1 - 3e-29 100.2 9.9 4.4e-05 23.7 0.1 8.2 8 0 0 8 8 8 6 Ankyrin repeat Ank_4 PF13637.6 CCF42206.1 - 6.6e-27 93.5 0.1 9.5e-09 35.6 0.1 5.4 3 2 3 6 6 6 6 Ankyrin repeats (many copies) NACHT PF05729.12 CCF42206.1 - 0.0021 18.0 0.2 0.0044 16.9 0.2 1.5 1 0 0 1 1 1 1 NACHT domain MFS_1 PF07690.16 CCF42207.1 - 5.2e-07 28.9 22.2 7e-07 28.5 22.2 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Zip PF02535.22 CCF42207.1 - 0.36 10.0 6.0 0.057 12.6 1.4 1.9 2 0 0 2 2 2 0 ZIP Zinc transporter DUF3328 PF11807.8 CCF42208.1 - 8.5e-09 35.5 0.0 1e-08 35.3 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) TilS_C PF11734.8 CCF42208.1 - 0.088 12.3 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 TilS substrate C-terminal domain Peptidase_S10 PF00450.22 CCF42209.1 - 8.8e-49 167.0 3.4 1.1e-48 166.7 3.4 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase GHMP_kinases_N PF00288.26 CCF42209.1 - 0.044 14.0 0.7 2.3 8.5 0.0 2.3 2 0 0 2 2 2 0 GHMP kinases N terminal domain BetaGal_dom4_5 PF13364.6 CCF42209.1 - 0.071 13.7 0.1 0.13 12.8 0.1 1.4 1 0 0 1 1 1 0 Beta-galactosidase jelly roll domain Sugar_tr PF00083.24 CCF42210.1 - 1.3e-18 67.1 6.0 1.5e-18 67.0 6.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter PQ-loop PF04193.14 CCF42210.1 - 0.083 12.7 0.7 0.18 11.6 0.7 1.6 1 0 0 1 1 1 0 PQ loop repeat MASE3 PF17159.4 CCF42210.1 - 0.9 9.1 7.2 0.21 11.2 0.5 2.1 1 1 0 2 2 2 0 Membrane-associated sensor domain SDF PF00375.18 CCF42211.1 - 1.8e-35 122.7 18.0 2.2e-35 122.5 18.0 1.0 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family DUF5313 PF17240.2 CCF42211.1 - 5.9 7.3 5.9 4 7.9 0.1 3.0 3 1 0 3 3 3 0 Family of unknown function (DUF5313) MAP17 PF15807.5 CCF42211.1 - 7.7 6.8 5.8 9.2 6.5 1.5 2.7 2 1 1 3 3 3 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Protoglobin PF11563.8 CCF42212.1 - 7.7e-60 201.4 0.1 9.2e-60 201.1 0.1 1.1 1 0 0 1 1 1 1 Protoglobin Cys_Met_Meta_PP PF01053.20 CCF42213.1 - 3.2e-30 104.9 0.0 3.6e-30 104.8 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme SPT6_acidic PF14632.6 CCF42214.1 - 0.01 16.4 2.1 0.01 16.4 2.1 2.0 2 0 0 2 2 2 0 Acidic N-terminal SPT6 DUF390 PF04094.14 CCF42214.1 - 0.012 13.9 0.5 0.014 13.7 0.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF390) TFIIF_alpha PF05793.12 CCF42214.1 - 0.013 14.1 10.2 0.02 13.5 10.2 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) CCDC106 PF15794.5 CCF42214.1 - 0.062 13.0 2.1 0.083 12.6 2.1 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Protocadherin PF08374.11 CCF42214.1 - 0.36 10.8 3.9 0.45 10.5 3.9 1.1 1 0 0 1 1 1 0 Protocadherin Ribosomal_60s PF00428.19 CCF42214.1 - 4.3 8.0 12.4 10 6.8 12.4 1.7 1 1 0 1 1 1 0 60s Acidic ribosomal protein PGA2 PF07543.12 CCF42214.1 - 5.9 6.9 10.4 1.7 8.6 7.9 1.5 1 1 0 1 1 1 0 Protein trafficking PGA2 BAR PF03114.18 CCF42216.1 - 2.9e-49 167.9 4.1 3.7e-49 167.5 4.1 1.1 1 0 0 1 1 1 1 BAR domain BAR_2 PF10455.9 CCF42216.1 - 1.4e-07 31.0 1.1 1.7e-07 30.7 1.1 1.1 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking OmpH PF03938.14 CCF42216.1 - 0.0063 16.9 3.7 0.0063 16.9 3.7 2.1 2 0 0 2 2 2 1 Outer membrane protein (OmpH-like) PMEI PF04043.15 CCF42216.1 - 0.011 16.1 0.3 0.019 15.3 0.3 1.4 1 0 0 1 1 1 0 Plant invertase/pectin methylesterase inhibitor GBP_C PF02841.14 CCF42216.1 - 0.55 9.6 6.3 0.86 8.9 6.3 1.2 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain DUF883 PF05957.13 CCF42216.1 - 2.6 8.7 7.8 11 6.7 7.7 2.1 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF883) DUF3391 PF11871.8 CCF42216.1 - 9.7 6.7 7.5 0.8 10.2 1.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3391) Glyco_hydro_62 PF03664.13 CCF42219.1 - 8.9e-154 510.6 11.7 1e-153 510.4 11.7 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 62 UPF0552 PF10574.9 CCF42219.1 - 0.19 11.0 0.1 0.34 10.2 0.1 1.3 1 0 0 1 1 1 0 Arp2/3-interacting proteins Arpin EzrA PF06160.12 CCF42220.1 - 0.017 13.3 3.3 0.029 12.6 3.3 1.3 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA DivIVA PF05103.13 CCF42220.1 - 5.9 7.0 7.5 0.76 9.9 1.6 2.4 2 1 1 3 3 3 0 DivIVA protein F-box-like PF12937.7 CCF42221.1 - 1.2e-10 41.1 0.0 2.5e-10 40.1 0.0 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCF42221.1 - 0.0007 19.4 0.0 0.0016 18.3 0.0 1.6 1 0 0 1 1 1 1 F-box domain Mito_carr PF00153.27 CCF42222.1 - 5.4e-62 205.8 1.7 1.3e-20 73.1 0.1 4.1 4 0 0 4 4 4 4 Mitochondrial carrier protein Sugar_tr PF00083.24 CCF42223.1 - 5.1e-81 272.8 11.4 6.4e-81 272.5 11.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF42223.1 - 2.9e-29 102.1 17.1 4e-29 101.7 17.1 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 CCF42223.1 - 0.00072 18.1 2.9 0.0073 14.8 0.3 2.1 2 0 0 2 2 2 2 Fungal trichothecene efflux pump (TRI12) FAD_binding_3 PF01494.19 CCF42224.1 - 3.5e-22 79.1 0.0 2.5e-15 56.6 0.0 2.3 2 1 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 CCF42224.1 - 2.4e-07 30.3 0.0 2.2e-06 27.2 0.0 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CCF42224.1 - 9.2e-06 25.0 0.1 1.5e-05 24.3 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain SE PF08491.10 CCF42224.1 - 0.0001 21.5 0.1 0.012 14.6 0.0 2.5 2 1 1 3 3 3 1 Squalene epoxidase NAD_binding_8 PF13450.6 CCF42224.1 - 0.00012 22.2 0.5 0.00028 21.0 0.5 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CCF42224.1 - 0.00035 20.3 1.2 0.004 16.8 0.9 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.22 CCF42224.1 - 0.00081 18.6 0.0 0.0031 16.7 0.0 1.8 2 0 0 2 2 2 1 Glucose inhibited division protein A FAD_oxidored PF12831.7 CCF42224.1 - 0.0012 18.3 0.2 0.0019 17.6 0.2 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 CCF42224.1 - 0.0031 16.3 0.1 0.0058 15.4 0.1 1.4 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox PF00070.27 CCF42224.1 - 0.0037 17.8 0.7 0.022 15.3 0.2 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCF42224.1 - 0.0044 16.3 0.0 0.012 14.9 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 CCF42224.1 - 0.0056 15.6 0.0 2 7.2 0.0 2.2 2 0 0 2 2 2 2 Tryptophan halogenase Thi4 PF01946.17 CCF42224.1 - 0.0084 15.4 0.2 0.015 14.6 0.2 1.4 1 0 0 1 1 1 1 Thi4 family AlaDh_PNT_C PF01262.21 CCF42224.1 - 0.026 13.8 0.3 0.063 12.6 0.3 1.6 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Lycopene_cycl PF05834.12 CCF42224.1 - 0.15 11.1 0.1 2.7 6.9 0.1 2.1 2 0 0 2 2 2 0 Lycopene cyclase protein NAD_binding_2 PF03446.15 CCF42225.1 - 3.3e-24 85.9 0.1 5.2e-24 85.2 0.1 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 CCF42225.1 - 2.9e-09 37.2 0.0 5.1e-09 36.4 0.0 1.4 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.17 CCF42225.1 - 0.0022 18.5 0.0 0.0051 17.4 0.0 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 CCF42225.1 - 0.012 15.7 0.0 0.034 14.2 0.0 1.8 1 1 1 2 2 2 0 Shikimate / quinate 5-dehydrogenase Antimicrobial11 PF08106.11 CCF42225.1 - 0.13 12.3 0.4 0.28 11.3 0.4 1.6 1 0 0 1 1 1 0 Formaecin family GDPD PF03009.17 CCF42227.1 - 0.14 11.9 0.0 0.2 11.4 0.0 1.2 1 0 0 1 1 1 0 Glycerophosphoryl diester phosphodiesterase family RNA_pol_Rpc34 PF05158.12 CCF42228.1 - 9.1e-102 340.9 0.0 1.2e-101 340.5 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase Rpc34 subunit RPA_C PF08784.11 CCF42228.1 - 0.029 15.0 0.0 0.17 12.6 0.0 2.3 3 0 0 3 3 3 0 Replication protein A C terminal Anillin_N PF16018.5 CCF42231.1 - 0.043 14.4 0.1 0.058 14.0 0.1 1.3 1 0 0 1 1 1 0 Anillin N-terminus NMT_C PF02799.15 CCF42233.1 - 2e-83 279.1 0.0 2.8e-83 278.6 0.0 1.2 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain NMT PF01233.19 CCF42233.1 - 5.6e-73 244.1 0.1 2.3e-72 242.1 0.0 1.9 2 0 0 2 2 2 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain Acetyltransf_9 PF13527.7 CCF42233.1 - 7.4e-06 26.1 0.1 0.0011 19.0 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CCF42233.1 - 0.0042 17.3 0.0 0.01 16.1 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family DUF3024 PF11225.8 CCF42233.1 - 0.079 13.2 0.0 0.19 12.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3024) DUF1576 PF07613.11 CCF42233.1 - 0.19 11.2 0.0 6.1 6.3 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1576) DUF4598 PF15370.6 CCF42233.1 - 0.83 10.2 4.9 3.7 8.0 4.9 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4598) PGA2 PF07543.12 CCF42233.1 - 2.8 7.9 7.0 5.6 6.9 7.0 1.4 1 0 0 1 1 1 0 Protein trafficking PGA2 Band_7 PF01145.25 CCF42234.1 - 1.4e-24 87.1 7.7 2.8e-24 86.1 7.7 1.5 1 1 0 1 1 1 1 SPFH domain / Band 7 family YdfA_immunity PF12127.8 CCF42234.1 - 0.00087 18.4 5.8 0.0012 18.0 5.8 1.2 1 0 0 1 1 1 1 SigmaW regulon antibacterial Atg14 PF10186.9 CCF42234.1 - 0.21 10.6 1.3 0.29 10.2 1.3 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 UcrQ PF02939.16 CCF42235.1 - 7.6e-37 125.1 0.3 8.8e-37 124.9 0.3 1.0 1 0 0 1 1 1 1 UcrQ family MaoC_dehydratas PF01575.19 CCF42236.1 - 3.1e-24 84.9 0.0 4.2e-24 84.5 0.0 1.1 1 0 0 1 1 1 1 MaoC like domain ECH_1 PF00378.20 CCF42237.1 - 5.1e-43 147.2 0.0 6.3e-43 146.9 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CCF42237.1 - 3e-18 66.4 0.1 8.8e-17 61.6 0.0 1.9 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 CCF42238.1 - 1.7e-58 197.9 0.0 2.1e-58 197.6 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CCF42238.1 - 5.9e-25 88.5 0.1 6.4e-24 85.1 0.1 1.9 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase TRI12 PF06609.13 CCF42239.1 - 1.1e-81 275.0 19.1 1.4e-81 274.7 19.1 1.0 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_1 PF07690.16 CCF42239.1 - 2.3e-26 92.6 48.4 2.3e-26 92.6 48.4 2.3 2 1 0 2 2 2 1 Major Facilitator Superfamily adh_short_C2 PF13561.6 CCF42240.1 - 4.3e-68 229.4 3.7 4.8e-68 229.2 3.7 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF42240.1 - 9.4e-51 172.0 1.7 1.1e-50 171.8 1.7 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF42240.1 - 2.8e-14 53.4 2.1 4.3e-14 52.8 2.1 1.2 1 0 0 1 1 1 1 KR domain Ldh_1_N PF00056.23 CCF42240.1 - 0.0089 16.1 0.2 0.015 15.4 0.2 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Epimerase PF01370.21 CCF42240.1 - 0.037 13.5 0.2 1.3 8.5 0.1 2.1 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family 3HCDH_N PF02737.18 CCF42240.1 - 0.037 13.9 0.3 0.057 13.3 0.3 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 CCF42240.1 - 0.076 13.3 0.2 0.13 12.5 0.2 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain ECH_1 PF00378.20 CCF42241.1 - 1.5e-20 73.6 0.2 1.3e-17 64.0 0.1 2.1 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CCF42241.1 - 0.0023 17.5 1.1 0.031 13.8 0.4 2.0 1 1 1 2 2 2 1 Enoyl-CoA hydratase/isomerase Epimerase PF01370.21 CCF42242.1 - 5.3e-14 52.3 0.0 1.2e-13 51.1 0.0 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CCF42242.1 - 9.8e-10 38.6 0.2 3e-09 37.0 0.1 1.8 2 0 0 2 2 2 1 NAD(P)H-binding 3Beta_HSD PF01073.19 CCF42242.1 - 1.5e-08 34.0 0.0 4.8e-08 32.3 0.0 1.7 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NmrA PF05368.13 CCF42242.1 - 0.0044 16.6 0.1 0.0074 15.9 0.1 1.3 1 0 0 1 1 1 1 NmrA-like family GDP_Man_Dehyd PF16363.5 CCF42242.1 - 0.0054 16.2 0.2 0.018 14.5 0.0 1.8 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 CCF42242.1 - 0.017 14.2 0.1 0.39 9.8 0.0 2.1 2 0 0 2 2 2 0 RmlD substrate binding domain adh_short PF00106.25 CCF42242.1 - 0.22 11.0 1.7 5.6 6.4 0.1 2.4 3 0 0 3 3 3 0 short chain dehydrogenase Glyco_hydro_16 PF00722.21 CCF42243.1 - 1.1e-05 24.9 0.0 3.9e-05 23.2 0.0 1.8 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 bZIP_1 PF00170.21 CCF42245.1 - 0.0019 18.2 8.4 0.0033 17.5 8.4 1.2 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 CCF42245.1 - 0.014 15.5 8.2 0.021 14.9 8.2 1.2 1 0 0 1 1 1 0 Basic region leucine zipper MAS20 PF02064.15 CCF42245.1 - 0.019 15.1 0.4 0.029 14.5 0.4 1.3 1 0 0 1 1 1 0 MAS20 protein import receptor adh_short_C2 PF13561.6 CCF42246.1 - 5e-47 160.4 4.4 6.5e-47 160.1 4.4 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF42246.1 - 2.8e-35 121.6 2.5 3.9e-35 121.1 2.5 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF42246.1 - 8.6e-09 35.5 2.6 1.2e-08 35.1 2.6 1.2 1 0 0 1 1 1 1 KR domain Cupin_2 PF07883.11 CCF42247.1 - 3.6e-13 49.0 0.0 5.8e-13 48.4 0.0 1.3 1 0 0 1 1 1 1 Cupin domain Cupin_3 PF05899.12 CCF42247.1 - 2.9e-05 23.7 0.0 4.7e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF861) AraC_binding PF02311.19 CCF42247.1 - 0.0063 16.4 0.0 0.0085 16.0 0.0 1.2 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_1 PF00190.22 CCF42247.1 - 0.0072 15.9 0.2 0.025 14.2 0.0 1.9 2 1 0 2 2 2 1 Cupin AraC_binding_2 PF14525.6 CCF42247.1 - 0.028 14.1 0.1 0.1 12.3 0.0 1.9 1 1 1 2 2 2 0 AraC-binding-like domain adh_short PF00106.25 CCF42250.1 - 5.4e-12 45.6 0.0 8.3e-12 45.0 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF42250.1 - 9.3e-10 38.5 0.0 1.4e-09 37.9 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase PI-PLC-C1 PF16670.5 CCF42252.1 - 7e-129 429.6 0.0 8e-129 429.4 0.0 1.0 1 0 0 1 1 1 1 Phosphoinositide phospholipase C, Ca2+-dependent p450 PF00067.22 CCF42253.1 - 1e-54 186.1 0.0 1.2e-54 185.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Sex_peptide PF08138.11 CCF42253.1 - 0.1 12.8 0.4 0.19 11.9 0.4 1.4 1 0 0 1 1 1 0 Sex peptide (SP) family COesterase PF00135.28 CCF42254.1 - 2.1e-68 231.4 0.0 2.5e-68 231.2 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CCF42254.1 - 4.7e-08 33.1 0.1 3.9e-07 30.1 0.1 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CCF42254.1 - 0.0021 17.6 0.2 0.0033 16.9 0.2 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Esterase PF00756.20 CCF42254.1 - 0.042 13.5 0.0 4.5 6.8 0.0 2.3 2 0 0 2 2 2 0 Putative esterase FAD_binding_3 PF01494.19 CCF42256.1 - 7.2e-75 252.4 0.0 8.8e-75 252.1 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.12 CCF42256.1 - 9.8e-30 103.8 0.0 1.8e-29 102.9 0.0 1.4 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain Pyr_redox_2 PF07992.14 CCF42256.1 - 2.8e-07 30.1 0.0 0.0002 20.7 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CCF42256.1 - 8.9e-05 21.4 0.5 0.00018 20.4 0.3 1.5 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox PF00070.27 CCF42256.1 - 0.00011 22.6 0.0 0.011 16.3 0.1 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCF42256.1 - 0.00094 19.4 0.1 0.0022 18.2 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 CCF42256.1 - 0.0016 17.6 0.2 0.0029 16.7 0.2 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein DAO PF01266.24 CCF42256.1 - 0.0035 17.0 0.1 0.31 10.6 0.1 2.2 1 1 1 2 2 2 1 FAD dependent oxidoreductase Trp_halogenase PF04820.14 CCF42256.1 - 0.009 14.9 0.0 0.014 14.3 0.0 1.2 1 0 0 1 1 1 1 Tryptophan halogenase AlaDh_PNT_C PF01262.21 CCF42256.1 - 0.013 14.8 0.0 0.023 14.0 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.17 CCF42256.1 - 0.015 14.6 0.0 0.025 13.8 0.0 1.2 1 0 0 1 1 1 0 Thi4 family GIDA PF01134.22 CCF42256.1 - 0.061 12.4 0.1 0.094 11.8 0.1 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 CCF42256.1 - 0.081 12.2 0.1 0.13 11.5 0.1 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase UDPG_MGDP_dh_N PF03721.14 CCF42256.1 - 0.16 11.5 0.0 0.25 10.9 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Condensation PF00668.20 CCF42257.1 - 3.1e-177 589.8 0.0 9.1e-60 202.6 0.0 5.5 4 1 0 4 4 4 4 Condensation domain AMP-binding PF00501.28 CCF42257.1 - 2.7e-141 471.0 0.0 6.4e-71 239.2 0.0 2.2 2 0 0 2 2 2 2 AMP-binding enzyme PP-binding PF00550.25 CCF42257.1 - 1.8e-37 127.5 0.1 1.3e-13 51.0 0.0 4.7 4 0 0 4 4 4 3 Phosphopantetheine attachment site O-FucT PF10250.9 CCF42258.1 - 2.9e-07 30.5 0.0 1.2e-06 28.4 0.0 2.1 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase GN3L_Grn1 PF08701.11 CCF42259.1 - 6e-25 87.1 17.9 1.1e-24 86.3 17.9 1.4 1 0 0 1 1 1 1 GNL3L/Grn1 putative GTPase MMR_HSR1 PF01926.23 CCF42259.1 - 7e-17 61.5 0.2 1.1e-12 48.0 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CCF42259.1 - 1.9e-08 34.4 0.0 7.2e-08 32.5 0.0 1.8 1 1 0 1 1 1 1 RsgA GTPase GTP_EFTU PF00009.27 CCF42259.1 - 7.4e-06 25.6 0.0 0.022 14.3 0.0 2.5 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 CCF42259.1 - 3.3e-05 24.0 8.9 0.038 14.0 0.5 3.8 4 0 0 4 4 4 2 Dynamin family FeoB_N PF02421.18 CCF42259.1 - 0.001 18.6 0.5 0.017 14.7 0.1 2.5 2 1 0 2 2 2 1 Ferrous iron transport protein B Nuc_deoxyri_tr2 PF15891.5 CCF42259.1 - 0.012 15.9 0.8 0.5 10.7 0.0 2.6 2 0 0 2 2 2 0 Nucleoside 2-deoxyribosyltransferase like AIG1 PF04548.16 CCF42259.1 - 0.034 13.5 0.2 0.094 12.0 0.1 1.7 2 0 0 2 2 2 0 AIG1 family Roc PF08477.13 CCF42259.1 - 0.073 13.3 0.1 7.2 6.9 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase MeaB PF03308.16 CCF42259.1 - 0.078 11.9 0.0 0.078 11.9 0.0 2.3 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB RRN3 PF05327.11 CCF42259.1 - 2.3 6.7 5.1 3.1 6.2 5.1 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Eisosome1 PF12757.7 CCF42261.1 - 3e-44 150.3 12.1 3e-44 150.3 12.1 2.4 2 0 0 2 2 2 1 Eisosome protein 1 EZH2_WD-Binding PF11616.8 CCF42261.1 - 0.14 12.3 0.2 3.9 7.7 0.0 2.6 2 0 0 2 2 2 0 WD repeat binding protein EZH2 DUF4778 PF16008.5 CCF42261.1 - 0.19 11.8 12.8 0.23 11.5 12.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4778) DUF4407 PF14362.6 CCF42261.1 - 9.2 5.5 20.6 0.11 11.8 2.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Frag1 PF10277.9 CCF42262.1 - 3e-40 138.1 16.3 3.4e-40 137.9 16.3 1.0 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family LSM PF01423.22 CCF42263.1 - 3.1e-16 58.8 0.2 4.4e-16 58.3 0.2 1.2 1 0 0 1 1 1 1 LSM domain Ribosomal_L7Ae PF01248.26 CCF42264.1 - 2.4e-22 78.5 0.3 9.9e-22 76.5 0.3 2.0 1 1 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family SAPS PF04499.15 CCF42264.1 - 0.17 10.6 3.9 0.15 10.8 0.1 1.9 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein ORC_WH_C PF18137.1 CCF42264.1 - 8.4 6.5 8.7 13 5.9 0.0 2.2 2 0 0 2 2 2 0 Origin recognition complex winged helix C-terminal DUF1761 PF08570.10 CCF42265.1 - 7.4e-27 94.1 3.6 8.3e-27 93.9 3.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1761) Bac_export_2 PF01312.19 CCF42265.1 - 0.17 11.1 0.1 0.19 10.9 0.1 1.1 1 0 0 1 1 1 0 FlhB HrpN YscU SpaS Family CBFD_NFYB_HMF PF00808.23 CCF42266.1 - 1.9e-12 47.3 3.1 2.9e-12 46.7 3.1 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIIA PF03153.13 CCF42266.1 - 0.0008 19.5 25.9 0.001 19.2 25.9 1.0 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Spt5_N PF11942.8 CCF42266.1 - 0.037 15.0 4.4 2.5 9.2 0.3 2.4 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal AdoHcyase PF05221.17 CCF42267.1 - 1.6e-129 431.4 0.0 4.4e-74 249.3 0.3 2.0 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 CCF42267.1 - 7.3e-83 276.5 2.9 1.2e-82 275.8 2.9 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 CCF42267.1 - 1.6e-06 27.6 0.2 4.2e-06 26.2 0.2 1.7 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ELFV_dehydrog PF00208.21 CCF42267.1 - 0.0055 16.5 0.1 0.0099 15.6 0.1 1.5 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase TrkA_N PF02254.18 CCF42267.1 - 0.0058 16.9 0.1 0.012 15.8 0.1 1.5 1 0 0 1 1 1 1 TrkA-N domain IlvN PF07991.12 CCF42267.1 - 0.0082 15.7 0.4 0.016 14.8 0.4 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain 3HCDH_N PF02737.18 CCF42267.1 - 0.0099 15.8 0.3 0.018 15.0 0.3 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Urocanase PF01175.18 CCF42267.1 - 0.13 11.9 0.5 0.22 11.1 0.5 1.4 1 0 0 1 1 1 0 Urocanase Rossmann-like domain NinF PF05810.12 CCF42268.1 - 0.084 12.7 0.0 0.23 11.4 0.0 1.8 1 0 0 1 1 1 0 NinF protein zf-Di19 PF05605.12 CCF42269.1 - 5.9 7.3 6.8 54 4.2 2.2 3.1 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding Peptidase_S8 PF00082.22 CCF42270.1 - 5.6e-23 81.6 0.0 8.4e-23 81.1 0.0 1.3 1 0 0 1 1 1 1 Subtilase family Ribonuc_L-PSP PF01042.21 CCF42271.1 - 2e-11 44.0 0.0 2.7e-11 43.5 0.0 1.1 1 0 0 1 1 1 1 Endoribonuclease L-PSP DDE_1 PF03184.19 CCF42272.1 - 1.5e-36 125.7 0.0 2.1e-36 125.2 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 CCF42272.1 - 0.00019 21.2 0.0 0.00053 19.8 0.0 1.7 2 0 0 2 2 2 1 DDE superfamily endonuclease Clr5 PF14420.6 CCF42274.1 - 4.8e-13 49.1 0.2 1.1e-12 47.9 0.2 1.7 1 0 0 1 1 1 1 Clr5 domain XS PF03468.14 CCF42274.1 - 0.0038 17.5 0.1 0.0095 16.2 0.1 1.7 1 0 0 1 1 1 1 XS domain DUF3965 PF13112.6 CCF42274.1 - 0.094 11.9 0.3 0.28 10.3 0.2 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3965) N2227 PF07942.12 CCF42275.1 - 5.9e-99 330.7 0.0 7.2e-99 330.4 0.0 1.1 1 0 0 1 1 1 1 N2227-like protein Methyltransf_12 PF08242.12 CCF42275.1 - 0.0071 17.1 0.1 0.072 13.8 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF42275.1 - 0.015 16.0 0.0 0.11 13.2 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_23 PF13489.6 CCF42275.1 - 0.015 15.2 0.0 0.028 14.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Fungal_trans PF04082.18 CCF42277.1 - 3.3e-27 95.2 0.1 7.8e-27 94.0 0.0 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain Pex14_N PF04695.13 CCF42277.1 - 6.2 7.5 10.0 0.19 12.4 2.7 2.0 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Aldo_ket_red PF00248.21 CCF42278.1 - 3e-24 85.7 0.0 2.9e-23 82.5 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family DUF3435 PF11917.8 CCF42280.1 - 1.4e-108 363.6 0.2 8.1e-108 361.0 0.2 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF3435) Phage_int_SAM_5 PF13102.6 CCF42280.1 - 0.066 13.5 0.1 0.25 11.7 0.0 2.0 2 0 0 2 2 2 0 Phage integrase SAM-like domain Milton PF12448.8 CCF42280.1 - 0.087 12.9 0.4 0.25 11.4 0.4 1.7 1 0 0 1 1 1 0 Kinesin associated protein zf-C2H2 PF00096.26 CCF42280.1 - 4.7 7.9 8.7 2.7 8.6 1.4 2.9 2 0 0 2 2 2 0 Zinc finger, C2H2 type NOT2_3_5 PF04153.18 CCF42281.1 - 1.1e-41 142.0 8.7 2.4e-41 140.9 8.7 1.6 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family AKNA PF12443.8 CCF42281.1 - 0.011 16.3 0.7 0.048 14.3 0.7 2.1 1 0 0 1 1 1 0 AT-hook-containing transcription factor DUF2373 PF10180.9 CCF42281.1 - 0.012 15.4 3.5 0.024 14.5 3.5 1.5 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2373) HUN PF08729.10 CCF42281.1 - 0.025 14.6 0.9 0.053 13.5 0.9 1.5 1 0 0 1 1 1 0 HPC2 and ubinuclein domain Hamartin PF04388.12 CCF42281.1 - 4.1 6.0 10.1 4.5 5.8 10.1 1.2 1 0 0 1 1 1 0 Hamartin protein Aminotran_3 PF00202.21 CCF42282.1 - 0.0013 17.4 0.0 0.0014 17.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III MCM PF00493.23 CCF42283.1 - 9.3e-81 270.2 0.7 1.9e-80 269.2 0.7 1.4 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 CCF42283.1 - 1.1e-31 109.4 0.0 1.9e-31 108.5 0.0 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_N PF14551.6 CCF42283.1 - 1.3e-11 45.0 0.0 3.1e-11 43.8 0.0 1.6 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 CCF42283.1 - 8.2e-08 31.9 0.1 1.7e-06 27.6 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 CCF42283.1 - 0.0017 18.3 0.0 0.0043 16.9 0.0 1.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 CCF42283.1 - 0.0061 16.3 0.0 0.018 14.7 0.0 1.7 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_5 PF07728.14 CCF42283.1 - 0.11 12.5 0.0 0.25 11.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Peptidase_S28 PF05577.12 CCF42284.1 - 6.8e-47 160.2 0.6 1.1e-46 159.6 0.6 1.2 1 0 0 1 1 1 1 Serine carboxypeptidase S28 Abhydrolase_6 PF12697.7 CCF42286.1 - 0.058 14.0 0.0 0.065 13.8 0.0 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase family MFS_1 PF07690.16 CCF42287.1 - 7.7e-29 100.7 17.5 9.1e-29 100.5 17.5 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF42287.1 - 1.4e-08 34.1 4.4 2.1e-08 33.5 3.4 1.7 1 1 0 1 1 1 1 Sugar (and other) transporter ADH_N PF08240.12 CCF42288.1 - 5e-27 93.9 1.8 1.2e-26 92.8 1.8 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCF42288.1 - 9.6e-19 67.7 1.9 2e-17 63.4 1.9 2.2 1 1 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 CCF42288.1 - 9.3e-09 35.1 1.1 0.00025 20.6 0.1 2.7 2 1 0 2 2 2 2 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 CCF42288.1 - 0.00015 21.2 0.5 0.00015 21.2 0.5 1.6 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain ADH_zinc_N_2 PF13602.6 CCF42288.1 - 0.0046 18.0 0.0 0.012 16.7 0.0 1.8 1 1 0 1 1 1 1 Zinc-binding dehydrogenase UDPG_MGDP_dh_N PF03721.14 CCF42288.1 - 0.0063 16.1 0.9 0.0088 15.6 0.2 1.6 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ThiF PF00899.21 CCF42288.1 - 0.0097 15.3 0.1 0.018 14.4 0.1 1.3 1 0 0 1 1 1 1 ThiF family ApbA PF02558.16 CCF42288.1 - 0.023 14.4 0.1 0.038 13.6 0.1 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Pyr_redox_2 PF07992.14 CCF42288.1 - 0.024 13.9 0.3 0.097 11.9 0.3 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 CCF42288.1 - 0.033 14.1 0.4 0.053 13.4 0.4 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain TrkA_N PF02254.18 CCF42288.1 - 0.044 14.0 0.1 0.078 13.3 0.1 1.3 1 0 0 1 1 1 0 TrkA-N domain NAD_binding_8 PF13450.6 CCF42288.1 - 0.052 13.8 1.8 0.12 12.6 0.8 2.1 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Shikimate_DH PF01488.20 CCF42288.1 - 0.056 13.5 0.1 0.12 12.4 0.1 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase AdoHcyase_NAD PF00670.21 CCF42288.1 - 0.084 12.9 0.3 0.17 11.9 0.3 1.5 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain NADH_4Fe-4S PF10589.9 CCF42288.1 - 0.088 12.9 1.0 0.2 11.7 0.6 1.8 2 0 0 2 2 1 0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region Methyltransf_25 PF13649.6 CCF42288.1 - 0.1 13.3 0.1 0.26 12.0 0.1 1.7 1 0 0 1 1 1 0 Methyltransferase domain PALP PF00291.25 CCF42288.1 - 0.11 11.9 3.7 0.24 10.8 3.7 1.5 1 1 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme DUF281 PF03436.13 CCF42288.1 - 0.2 12.0 0.1 0.2 12.0 0.1 3.4 3 1 1 4 4 4 0 Domain of unknown function (DUF281) MitMem_reg PF13012.6 CCF42289.1 - 3.9e-11 43.3 1.6 1.2e-10 41.7 1.6 1.8 1 1 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.21 CCF42289.1 - 7.9e-07 29.1 0.0 1.6e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MF_alpha_N PF05436.11 CCF42291.1 - 0.018 15.0 0.1 0.022 14.7 0.1 1.1 1 0 0 1 1 1 0 Mating factor alpha precursor N-terminus ADH_zinc_N PF00107.26 CCF42292.1 - 4.3e-08 33.2 0.0 8.9e-08 32.2 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCF42292.1 - 6.3e-07 29.3 0.8 4.2e-06 26.6 0.6 2.0 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain Glyco_hydro_71 PF03659.14 CCF42294.1 - 1.2e-115 386.3 0.1 1.4e-115 386.1 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 71 zf-C2H2_jaz PF12171.8 CCF42296.1 - 0.095 13.0 0.4 0.16 12.3 0.4 1.4 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding ProRS-C_1 PF09180.11 CCF42297.1 - 1.8e-22 79.3 1.1 2.8e-22 78.7 0.2 1.8 2 0 0 2 2 2 1 Prolyl-tRNA synthetase, C-terminal tRNA-synt_2b PF00587.25 CCF42297.1 - 1e-20 74.5 0.0 2.2e-20 73.4 0.0 1.5 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 CCF42297.1 - 7.6e-18 64.5 0.0 1.7e-17 63.4 0.0 1.6 1 0 0 1 1 1 1 Anticodon binding domain Pkinase PF00069.25 CCF42298.1 - 2.8e-54 184.3 0.0 2.7e-51 174.5 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCF42298.1 - 1.7e-29 102.9 0.0 4.7e-28 98.2 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Seadorna_VP7 PF07387.11 CCF42298.1 - 0.00084 18.5 0.1 0.0017 17.5 0.1 1.4 1 0 0 1 1 1 1 Seadornavirus VP7 Kinase-like PF14531.6 CCF42298.1 - 0.0014 18.0 0.0 0.0021 17.4 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 CCF42298.1 - 0.082 11.7 0.0 0.12 11.1 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase Haspin_kinase PF12330.8 CCF42298.1 - 0.1 11.5 0.0 0.15 11.0 0.0 1.1 1 0 0 1 1 1 0 Haspin like kinase domain Glycoprot_B_PH1 PF17416.2 CCF42299.1 - 0.063 12.9 0.2 0.068 12.8 0.2 1.1 1 0 0 1 1 1 0 Herpesvirus Glycoprotein B CBP4 PF07960.11 CCF42299.1 - 0.07 13.0 3.0 0.12 12.3 3.0 1.3 1 0 0 1 1 1 0 CBP4 MFS_1 PF07690.16 CCF42302.1 - 8.8e-42 143.3 50.6 3.8e-41 141.2 46.1 2.6 1 1 1 2 2 2 1 Major Facilitator Superfamily SKG6 PF08693.10 CCF42303.1 - 2.5e-10 39.6 5.1 4.7e-10 38.7 5.1 1.4 1 0 0 1 1 1 1 Transmembrane alpha-helix domain RCR PF12273.8 CCF42303.1 - 0.00041 21.0 1.5 0.001 19.7 1.5 1.6 1 0 0 1 1 1 1 Chitin synthesis regulation, resistance to Congo red DUF4448 PF14610.6 CCF42303.1 - 0.011 15.5 0.1 0.02 14.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) PRR18 PF15671.5 CCF42303.1 - 0.84 9.5 9.3 2 8.2 9.3 1.6 1 0 0 1 1 1 0 Proline-rich protein family 18 Hexokinase_2 PF03727.16 CCF42304.1 - 1.7e-66 224.1 0.0 2e-65 220.6 0.0 2.0 1 1 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 CCF42304.1 - 2.5e-64 216.8 0.0 3.6e-64 216.3 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Zn_clus PF00172.18 CCF42305.1 - 3e-07 30.4 9.2 4.9e-07 29.7 9.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glucosamine_iso PF01182.20 CCF42306.1 - 2.8e-25 89.5 0.0 3.9e-25 89.1 0.0 1.2 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase FAD_binding_8 PF08022.12 CCF42306.1 - 0.034 14.2 0.0 0.073 13.2 0.0 1.5 1 0 0 1 1 1 0 FAD-binding domain FabA PF07977.13 CCF42306.1 - 0.13 11.9 0.0 0.32 10.6 0.0 1.7 1 1 0 1 1 1 0 FabA-like domain AA_permease_2 PF13520.6 CCF42307.1 - 4.8e-58 197.0 43.7 5.6e-58 196.8 43.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CCF42307.1 - 1.1e-23 83.6 35.6 1.4e-23 83.2 35.6 1.0 1 0 0 1 1 1 1 Amino acid permease RRM_1 PF00076.22 CCF42309.1 - 2.1e-14 53.1 0.0 5.2e-14 51.8 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CCF42309.1 - 0.0083 15.7 0.0 0.019 14.6 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 CCF42309.1 - 0.072 13.2 0.2 0.22 11.6 0.0 1.9 2 0 0 2 2 2 0 Limkain b1 SMN PF06003.12 CCF42310.1 - 2.9e-07 30.0 3.9 4.3e-05 22.9 0.3 2.4 2 1 1 3 3 3 2 Survival motor neuron protein (SMN) F-box-like PF12937.7 CCF42311.1 - 2.1e-10 40.3 0.0 7e-10 38.6 0.0 1.9 1 0 0 1 1 1 1 F-box-like LRR_6 PF13516.6 CCF42311.1 - 1.4e-08 34.1 0.1 0.18 12.0 0.0 6.1 7 0 0 7 7 7 2 Leucine Rich repeat F-box PF00646.33 CCF42311.1 - 1.3e-07 31.3 0.0 5.2e-07 29.4 0.0 2.1 1 0 0 1 1 1 1 F-box domain LRR_4 PF12799.7 CCF42311.1 - 0.0024 18.2 9.1 3.3 8.3 0.0 5.4 4 2 2 6 6 6 3 Leucine Rich repeats (2 copies) DUF3726 PF12525.8 CCF42311.1 - 0.094 12.8 0.0 23 5.2 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3726) DUF5308 PF17233.2 CCF42311.1 - 0.2 11.9 1.8 0.45 10.7 1.8 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5308) p47_phox_C PF08944.11 CCF42311.1 - 3.1 7.3 8.4 0.23 10.9 1.9 2.4 3 0 0 3 3 3 0 NADPH oxidase subunit p47Phox, C terminal domain RabGAP-TBC PF00566.18 CCF42312.1 - 8.8e-32 110.5 0.0 2e-29 102.8 0.0 2.2 1 1 0 1 1 1 1 Rab-GTPase-TBC domain HET PF06985.11 CCF42313.1 - 3.9e-25 88.9 0.0 6.8e-25 88.1 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) DUF1264 PF06884.11 CCF42314.1 - 8e-63 211.1 1.1 1.5e-61 207.0 1.1 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF1264) TMEM240 PF15207.6 CCF42314.1 - 0.042 13.6 0.0 0.074 12.8 0.0 1.3 1 0 0 1 1 1 0 TMEM240 family Helicase_C PF00271.31 CCF42316.1 - 2.1e-15 57.0 0.1 7.5e-15 55.2 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 CCF42316.1 - 2.3e-12 46.3 0.0 4.5e-12 45.4 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Prok-RING_4 PF14447.6 CCF42316.1 - 0.00011 22.0 1.3 0.00011 22.0 1.3 2.2 3 0 0 3 3 3 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 CCF42316.1 - 0.00021 21.2 4.9 0.00057 19.8 4.9 1.8 1 1 0 1 1 1 1 zinc-RING finger domain ERCC3_RAD25_C PF16203.5 CCF42316.1 - 0.0035 16.6 0.0 0.0054 16.0 0.0 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase zf-RING_UBOX PF13445.6 CCF42316.1 - 0.024 14.7 3.3 0.033 14.2 1.6 2.1 1 1 1 2 2 2 0 RING-type zinc-finger zf-C3HC4 PF00097.25 CCF42316.1 - 0.041 13.8 6.2 0.11 12.4 6.2 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CCF42316.1 - 0.045 13.6 8.1 0.15 11.9 8.1 1.9 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF5383 PF17355.2 CCF42316.1 - 0.068 13.5 0.0 0.15 12.4 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5383) zf-RING_2 PF13639.6 CCF42316.1 - 0.48 10.8 8.6 0.46 10.9 6.8 2.0 2 0 0 2 2 2 0 Ring finger domain zf-C3HC4_2 PF13923.6 CCF42316.1 - 5.2 7.0 11.7 6.5 6.7 6.7 3.3 3 1 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) DDE_1 PF03184.19 CCF42317.1 - 5.7e-10 39.1 0.1 1.3e-09 37.9 0.0 1.6 3 0 0 3 3 3 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 CCF42317.1 - 5.6e-09 35.9 0.0 1.2e-08 34.8 0.0 1.6 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain Amidohydro_1 PF01979.20 CCF42320.1 - 8.9e-11 41.7 0.0 1.5e-10 40.9 0.0 1.3 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 CCF42320.1 - 6.2e-05 22.6 2.5 0.0055 16.2 0.2 2.8 2 2 1 3 3 3 2 Amidohydrolase family Wbp11 PF09429.10 CCF42322.1 - 2e-23 82.6 9.1 2e-23 82.6 9.1 2.4 2 0 0 2 2 2 1 WW domain binding protein 11 PAG PF15347.6 CCF42322.1 - 0.0084 15.2 2.2 0.012 14.7 2.2 1.2 1 0 0 1 1 1 1 Phosphoprotein associated with glycosphingolipid-enriched Pkinase PF00069.25 CCF42323.1 - 1.7e-60 204.7 0.0 2.6e-59 200.7 0.0 2.3 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF42323.1 - 4.9e-28 98.1 0.4 1.9e-19 70.0 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_C PF00433.24 CCF42323.1 - 1.3e-05 25.8 1.5 4.9e-05 23.9 1.5 2.1 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.6 CCF42323.1 - 0.0065 15.8 0.1 0.025 13.9 0.0 1.9 3 0 0 3 3 3 1 Kinase-like APH PF01636.23 CCF42323.1 - 0.0074 16.2 0.1 0.11 12.5 0.1 2.5 1 1 1 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 CCF42323.1 - 0.034 13.1 0.0 0.06 12.3 0.0 1.4 1 1 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 CCF42323.1 - 0.037 13.4 0.0 0.068 12.5 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family MA3 PF02847.17 CCF42324.1 - 6.4e-25 87.3 0.0 2.5e-24 85.4 0.0 2.0 2 0 0 2 2 2 1 MA3 domain MIF4G PF02854.19 CCF42324.1 - 1.6e-06 27.9 1.2 3.8e-06 26.7 0.0 2.2 3 0 0 3 3 3 1 MIF4G domain Cnd1 PF12717.7 CCF42324.1 - 0.013 15.5 0.1 0.033 14.2 0.1 1.6 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 RIFIN PF02009.16 CCF42325.1 - 0.13 12.1 4.4 0.16 11.8 4.4 1.0 1 0 0 1 1 1 0 Rifin ENOD40 PF08247.11 CCF42325.1 - 0.19 11.8 0.7 0.35 10.9 0.7 1.5 1 0 0 1 1 1 0 ENOD40 protein CFEM PF05730.11 CCF42325.1 - 1.1 9.4 16.3 2.3 8.4 16.1 1.9 1 1 0 1 1 1 0 CFEM domain G_path_suppress PF15991.5 CCF42325.1 - 1.3 9.1 3.8 1.5 8.9 3.8 1.1 1 0 0 1 1 1 0 G-protein pathway suppressor DUF515 PF04415.12 CCF42325.1 - 3.2 6.0 6.0 3.6 5.9 6.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF515) Vfa1 PF08432.10 CCF42327.1 - 8.1e-59 199.0 19.4 9.1e-59 198.8 19.4 1.0 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 GREB1 PF15782.5 CCF42327.1 - 0.031 11.4 0.7 0.035 11.3 0.7 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer RR_TM4-6 PF06459.12 CCF42327.1 - 0.066 13.0 12.8 0.088 12.6 12.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF908 PF06012.12 CCF42327.1 - 0.14 11.6 1.9 0.15 11.5 1.9 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) CDC45 PF02724.14 CCF42327.1 - 0.17 10.1 16.6 0.19 10.0 16.6 1.0 1 0 0 1 1 1 0 CDC45-like protein SLC12 PF03522.15 CCF42327.1 - 0.44 9.5 7.5 0.48 9.4 7.5 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DUF1168 PF06658.12 CCF42327.1 - 0.69 9.7 31.7 0.036 13.9 26.4 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1168) SAPS PF04499.15 CCF42327.1 - 1 8.0 9.6 1.2 7.8 9.6 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein 60KD_IMP PF02096.20 CCF42327.1 - 1.1 9.2 3.7 1.6 8.6 3.7 1.2 1 0 0 1 1 1 0 60Kd inner membrane protein DUF913 PF06025.12 CCF42327.1 - 1.2 8.0 4.9 1.3 7.9 4.9 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) PPL5 PF18168.1 CCF42327.1 - 2.4 7.4 10.6 3 7.0 10.6 1.2 1 0 0 1 1 1 0 Prim-pol family 5 DUF2151 PF10221.9 CCF42327.1 - 3.8 6.0 12.8 4.4 5.8 12.8 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator Presenilin PF01080.17 CCF42327.1 - 4.2 6.0 11.1 5 5.8 11.1 1.1 1 0 0 1 1 1 0 Presenilin NPR3 PF03666.13 CCF42327.1 - 4.6 5.9 14.7 5.2 5.7 14.7 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Zip PF02535.22 CCF42327.1 - 5 6.2 7.6 5.7 6.1 7.6 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter ATP11 PF06644.11 CCF42327.1 - 5.1 6.8 15.6 6.5 6.5 15.6 1.2 1 0 0 1 1 1 0 ATP11 protein Pet100 PF09803.9 CCF42327.1 - 5.5 7.6 6.7 1.3 9.6 2.6 2.0 2 0 0 2 2 2 0 Pet100 Borrelia_P83 PF05262.11 CCF42327.1 - 6.5 5.1 22.3 8 4.8 22.3 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein Arrestin_N PF00339.29 CCF42328.1 - 7.2e-06 26.1 0.4 4.8e-05 23.4 0.4 2.0 1 1 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Bul1_N PF04425.12 CCF42328.1 - 0.079 11.7 1.9 0.32 9.7 0.5 1.9 1 1 1 2 2 2 0 Bul1 N terminus Vps26 PF03643.15 CCF42328.1 - 0.18 10.8 0.0 0.21 10.6 0.0 1.1 1 0 0 1 1 1 0 Vacuolar protein sorting-associated protein 26 Ndc80_HEC PF03801.13 CCF42330.1 - 4.5e-62 208.2 0.4 7.6e-62 207.5 0.4 1.4 1 0 0 1 1 1 1 HEC/Ndc80p family Spc7 PF08317.11 CCF42330.1 - 1.4e-05 24.1 10.8 1.4e-05 24.1 10.8 3.1 4 0 0 4 4 4 2 Spc7 kinetochore protein DHR10 PF18595.1 CCF42330.1 - 0.00038 20.5 15.0 0.00038 20.5 15.0 3.1 3 0 0 3 3 3 1 Designed helical repeat protein 10 domain Fungal_TACC PF12709.7 CCF42330.1 - 0.0012 19.3 17.4 0.21 12.0 0.2 4.6 3 1 1 4 4 4 2 Fungal Transforming acidic coiled-coil (TACC) proteins TPR_MLP1_2 PF07926.12 CCF42330.1 - 0.0031 17.6 26.1 0.0068 16.5 11.5 3.4 3 0 0 3 3 3 1 TPR/MLP1/MLP2-like protein ERM PF00769.19 CCF42330.1 - 0.0035 17.2 7.5 0.0035 17.2 7.5 3.1 3 0 0 3 3 3 1 Ezrin/radixin/moesin family Ntox28 PF15605.6 CCF42330.1 - 0.012 15.9 2.1 0.012 15.9 2.1 3.2 3 0 0 3 3 3 0 Bacterial toxin 28 FliJ PF02050.16 CCF42330.1 - 0.022 15.0 22.4 0.05 13.8 6.5 3.1 4 0 0 4 4 2 0 Flagellar FliJ protein NPV_P10 PF05531.12 CCF42330.1 - 0.038 14.5 1.8 3 8.4 0.7 3.4 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein PEP-utilisers_N PF05524.13 CCF42330.1 - 0.053 13.7 18.5 0.55 10.4 0.3 4.2 2 1 1 4 4 4 0 PEP-utilising enzyme, N-terminal FlaC_arch PF05377.11 CCF42330.1 - 0.25 11.8 17.6 5.4 7.5 0.4 4.7 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) FlxA PF14282.6 CCF42330.1 - 0.5 10.4 7.0 4.3 7.4 0.1 3.2 2 1 1 3 3 3 0 FlxA-like protein GAS PF13851.6 CCF42330.1 - 0.86 8.9 27.7 0.9 8.9 12.7 3.3 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding AAA_32 PF13654.6 CCF42330.1 - 0.87 8.3 16.3 0.63 8.8 5.9 2.5 1 1 1 2 2 2 0 AAA domain Takusan PF04822.13 CCF42330.1 - 0.95 9.4 12.0 1.5 8.8 6.6 3.4 2 2 2 4 4 4 0 Takusan TMF_TATA_bd PF12325.8 CCF42330.1 - 1.2 9.4 27.1 1.1 9.5 11.7 3.5 3 0 0 3 3 3 0 TATA element modulatory factor 1 TATA binding DUF745 PF05335.13 CCF42330.1 - 1.6 8.4 9.7 3.5 7.3 2.9 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF745) Phage_GP20 PF06810.11 CCF42330.1 - 2.3 8.0 19.8 1.7 8.4 8.6 3.9 2 1 2 4 4 4 0 Phage minor structural protein GP20 Tropomyosin_1 PF12718.7 CCF42330.1 - 2.4 8.3 32.7 2.1 8.5 19.2 3.7 2 1 1 3 3 3 0 Tropomyosin like COG5 PF10392.9 CCF42330.1 - 2.6 8.2 6.9 1.6 8.9 2.2 2.8 3 0 0 3 3 3 0 Golgi transport complex subunit 5 AAA_23 PF13476.6 CCF42330.1 - 2.7 8.5 14.5 0.68 10.4 6.9 2.6 3 0 0 3 3 2 0 AAA domain BLOC1_2 PF10046.9 CCF42330.1 - 2.9 8.3 21.4 0.24 11.7 3.3 4.3 4 1 1 5 5 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 STAT_alpha PF01017.20 CCF42330.1 - 3.2 7.6 11.1 0.25 11.2 4.0 2.6 3 0 0 3 3 3 0 STAT protein, all-alpha domain Syntaxin_2 PF14523.6 CCF42330.1 - 3.4 8.1 10.9 0.22 11.9 3.8 2.6 2 1 1 3 3 3 0 Syntaxin-like protein DUF948 PF06103.11 CCF42330.1 - 3.7 7.9 5.1 3.8 7.8 1.0 3.1 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF1664 PF07889.12 CCF42330.1 - 3.8 7.6 17.0 0.19 11.7 0.6 4.0 4 1 1 5 5 5 0 Protein of unknown function (DUF1664) CENP-H PF05837.12 CCF42330.1 - 4.7 7.7 21.9 0.56 10.6 7.9 3.4 3 0 0 3 3 3 0 Centromere protein H (CENP-H) Csm1_N PF18504.1 CCF42330.1 - 6.1 7.3 24.1 1.1 9.7 2.5 4.1 3 1 1 4 4 4 0 Csm1 N-terminal domain DUF4200 PF13863.6 CCF42330.1 - 6.7 7.1 31.9 3.4 8.1 15.1 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4200) DivIC PF04977.15 CCF42330.1 - 7.6 6.4 21.3 3.6 7.4 1.6 4.3 3 1 1 4 4 4 0 Septum formation initiator DUF16 PF01519.16 CCF42330.1 - 8.1 7.0 14.9 0.46 11.0 6.0 2.9 3 1 0 3 3 2 0 Protein of unknown function DUF16 DUF4404 PF14357.6 CCF42330.1 - 9.4 7.0 17.7 2.7 8.7 5.2 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4404) APG6_N PF17675.1 CCF42330.1 - 9.8 6.7 37.5 3 8.4 3.0 4.2 2 1 1 4 4 4 0 Apg6 coiled-coil region HTH_psq PF05225.16 CCF42331.1 - 4.4e-09 35.9 0.0 7.4e-09 35.2 0.0 1.4 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.16 CCF42331.1 - 2.1e-08 34.1 0.0 5e-08 32.8 0.0 1.6 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_23 PF13384.6 CCF42331.1 - 0.00076 19.2 0.1 0.0029 17.4 0.0 2.0 2 0 0 2 2 2 1 Homeodomain-like domain TPR_21 PF09976.9 CCF42333.1 - 0.011 15.4 0.9 0.015 15.0 0.1 1.5 2 0 0 2 2 2 0 Tetratricopeptide repeat-like domain DUF3425 PF11905.8 CCF42334.1 - 1.3e-18 67.2 0.0 2.1e-18 66.5 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) Aldo_ket_red PF00248.21 CCF42335.1 - 2.1e-62 211.0 0.0 2.3e-62 210.8 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family AAA PF00004.29 CCF42336.1 - 3.4e-16 59.9 0.0 7.2e-16 58.8 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CCF42336.1 - 0.00034 20.6 0.0 0.00074 19.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CCF42336.1 - 0.0014 19.1 0.1 0.0039 17.6 0.1 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 CCF42336.1 - 0.0015 18.8 0.1 0.007 16.6 0.1 2.1 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 CCF42336.1 - 0.059 13.5 0.2 0.3 11.2 0.0 2.3 3 0 0 3 3 3 0 AAA domain AAA_25 PF13481.6 CCF42336.1 - 0.14 11.8 0.1 0.41 10.2 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 CCF42336.1 - 0.19 12.3 1.1 0.49 10.9 0.0 2.3 3 0 0 3 3 3 0 AAA domain HTH_Tnp_Tc5 PF03221.16 CCF42337.1 - 2.2e-12 46.8 0.1 6.3e-12 45.3 0.0 1.8 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 CCF42337.1 - 2.7e-09 36.6 0.1 4.8e-09 35.8 0.1 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_23 PF13384.6 CCF42337.1 - 0.0023 17.7 0.2 0.0094 15.7 0.0 2.1 2 0 0 2 2 2 1 Homeodomain-like domain CENP-B_N PF04218.13 CCF42337.1 - 0.014 15.0 0.0 0.026 14.1 0.0 1.4 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain TilS PF09179.11 CCF42337.1 - 0.043 14.3 0.1 1.6 9.3 0.2 2.5 2 0 0 2 2 2 0 TilS substrate binding domain HTH_28 PF13518.6 CCF42337.1 - 0.056 13.6 0.7 0.2 11.8 0.0 2.2 3 0 0 3 3 3 0 Helix-turn-helix domain HTH_8 PF02954.19 CCF42337.1 - 0.1 12.4 0.1 0.59 10.0 0.0 2.2 1 1 1 2 2 2 0 Bacterial regulatory protein, Fis family GRDP-like PF07173.12 CCF42338.1 - 3.5e-15 56.9 0.9 6e-15 56.1 0.1 1.8 2 0 0 2 2 2 1 Glycine-rich domain-containing protein-like DUF459 PF04311.13 CCF42338.1 - 0.14 11.2 0.1 0.22 10.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF459) ABC_tran PF00005.27 CCF42341.1 - 1e-25 90.8 0.0 4.3e-25 88.8 0.0 2.0 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.6 CCF42341.1 - 2.3e-05 24.4 0.0 0.16 11.8 0.0 2.3 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CCF42341.1 - 0.0037 17.0 0.0 0.0083 15.8 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain SMC_N PF02463.19 CCF42341.1 - 0.0052 16.2 0.0 0.14 11.6 0.0 2.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_25 PF13481.6 CCF42341.1 - 0.0058 16.2 0.1 0.015 14.9 0.0 1.6 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 CCF42341.1 - 0.0092 15.9 0.0 0.019 14.9 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_18 PF13238.6 CCF42341.1 - 0.012 16.2 0.0 0.034 14.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 CCF42341.1 - 0.052 13.5 0.0 0.099 12.5 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_23 PF13476.6 CCF42341.1 - 0.053 14.0 0.1 0.16 12.4 0.1 1.8 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 CCF42341.1 - 0.066 13.5 0.0 0.21 11.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 CCF42341.1 - 0.092 13.1 0.0 0.2 12.0 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.6 CCF42341.1 - 0.13 12.4 0.0 0.26 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain bZIP_1 PF00170.21 CCF42343.1 - 7e-06 26.1 6.6 7e-06 26.1 6.6 1.7 2 0 0 2 2 2 1 bZIP transcription factor ComFB PF10719.9 CCF42343.1 - 0.22 11.6 1.5 0.44 10.7 1.5 1.4 1 0 0 1 1 1 0 Late competence development protein ComFB DUF5595 PF18077.1 CCF42343.1 - 0.25 11.4 1.0 0.35 11.0 0.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF5595) bZIP_2 PF07716.15 CCF42343.1 - 2.2 8.5 10.1 0.65 10.1 6.4 2.0 2 0 0 2 2 2 0 Basic region leucine zipper Pro-kuma_activ PF09286.11 CCF42344.1 - 5.7e-35 120.7 0.0 1.7e-34 119.1 0.0 1.7 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 CCF42344.1 - 0.0095 15.2 0.1 0.017 14.4 0.1 1.4 1 0 0 1 1 1 1 Subtilase family DUF3716 PF12511.8 CCF42348.1 - 1.9e-08 34.2 1.0 2.7e-08 33.7 1.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3716) LacAB_rpiB PF02502.18 CCF42348.1 - 0.057 13.4 0.1 0.07 13.1 0.1 1.1 1 0 0 1 1 1 0 Ribose/Galactose Isomerase DHquinase_I PF01487.15 CCF42349.1 - 1.2e-44 153.3 0.0 1.7e-44 152.8 0.0 1.3 1 0 0 1 1 1 1 Type I 3-dehydroquinase Cu_amine_oxid PF01179.20 CCF42351.1 - 2e-165 550.7 0.0 2.4e-165 550.4 0.0 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN2 PF02727.16 CCF42351.1 - 1.9e-07 31.2 0.0 4.2e-07 30.1 0.0 1.6 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain Cu_amine_oxidN3 PF02728.16 CCF42351.1 - 0.0001 22.6 0.0 0.00023 21.5 0.0 1.5 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain DUF918 PF06033.11 CCF42352.1 - 0.01 15.9 0.0 0.012 15.7 0.0 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF918) DUF3328 PF11807.8 CCF42354.1 - 7.2e-34 117.5 0.1 1e-33 117.0 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) adh_short_C2 PF13561.6 CCF42355.1 - 1.2e-52 178.8 0.2 1.5e-52 178.5 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF42355.1 - 2e-32 112.2 0.0 2.9e-32 111.7 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF42355.1 - 1.3e-05 25.2 0.3 2e-05 24.6 0.3 1.2 1 0 0 1 1 1 1 KR domain TPR_14 PF13428.6 CCF42357.1 - 2.3e-08 34.2 0.0 0.0017 19.0 0.1 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 CCF42357.1 - 7.1e-07 29.7 0.2 0.00069 20.1 0.1 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 CCF42357.1 - 3.1e-06 26.9 0.3 0.0061 16.6 0.1 2.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 CCF42357.1 - 0.0002 21.0 0.0 0.77 9.7 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 CCF42357.1 - 0.00031 20.9 0.2 0.0043 17.3 0.0 2.6 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 CCF42357.1 - 0.00035 20.5 0.0 0.021 15.0 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 CCF42357.1 - 0.0048 17.5 0.3 3.5 8.4 0.1 2.9 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 CCF42357.1 - 0.0078 16.2 0.1 0.87 9.8 0.0 3.6 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 CCF42357.1 - 0.12 13.0 0.0 1.4 9.7 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat NAPRTase_N PF17767.1 CCF42359.1 - 1.2e-36 125.8 0.1 2.1e-36 125.0 0.1 1.4 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain NAPRTase PF04095.16 CCF42359.1 - 3.2e-33 115.3 0.0 1.7e-25 90.0 0.0 2.2 1 1 1 2 2 2 2 Nicotinate phosphoribosyltransferase (NAPRTase) family Eisosome1 PF12757.7 CCF42360.1 - 2.9e-44 150.3 11.5 2.9e-44 150.3 11.5 4.2 3 2 1 4 4 4 1 Eisosome protein 1 Mgr1 PF08602.10 CCF42362.1 - 0.16 10.7 0.0 0.19 10.5 0.0 1.1 1 0 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit p450 PF00067.22 CCF42363.1 - 3.7e-33 115.0 0.0 4.6e-33 114.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 CENP-B_dimeris PF09026.10 CCF42364.1 - 7.5 7.0 8.9 2.2 8.8 5.2 2.0 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Amidohydro_1 PF01979.20 CCF42365.1 - 4.3e-31 108.5 0.0 5e-31 108.3 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 CCF42365.1 - 5.9e-07 29.3 1.3 0.00016 21.3 0.3 2.5 2 1 0 2 2 2 2 Amidohydrolase family AAA_lid_3 PF17862.1 CCF42365.1 - 0.23 11.3 1.7 1.5 8.7 0.0 2.6 2 1 0 2 2 2 0 AAA+ lid domain adh_short_C2 PF13561.6 CCF42366.1 - 1.3e-61 208.2 2.9 1.6e-61 207.9 2.9 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF42366.1 - 9.3e-50 168.8 1.6 1.1e-49 168.6 1.6 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF42366.1 - 3.1e-11 43.5 0.9 4.6e-11 43.0 0.9 1.2 1 0 0 1 1 1 1 KR domain Ammonium_transp PF00909.21 CCF42367.1 - 5.9e-118 394.0 30.5 6.7e-118 393.8 30.5 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family Ank_4 PF13637.6 CCF42368.1 - 0.036 14.7 0.0 1.5 9.5 0.0 3.0 3 0 0 3 3 3 0 Ankyrin repeats (many copies) DUF3606 PF12244.8 CCF42368.1 - 0.053 13.5 0.3 0.38 10.7 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3606) Glyco_hydro_43 PF04616.14 CCF42369.1 - 5.3e-26 91.6 0.0 6.2e-26 91.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 GMC_oxred_C PF05199.13 CCF42370.1 - 5.5e-10 39.9 0.4 1.5e-09 38.5 0.4 1.8 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_N PF00732.19 CCF42370.1 - 0.00013 21.5 0.0 0.0015 18.0 0.0 2.5 1 1 0 1 1 1 1 GMC oxidoreductase NAD_binding_8 PF13450.6 CCF42370.1 - 0.0095 16.1 0.2 0.036 14.3 0.2 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CCF42370.1 - 0.055 13.0 0.2 0.94 9.0 0.0 2.3 2 0 0 2 2 2 0 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCF42370.1 - 0.096 11.9 2.0 0.13 11.4 0.0 2.2 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Glyco_hydro_2_C PF02836.17 CCF42371.1 - 5.9e-26 91.3 0.0 6.9e-26 91.1 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_cc PF11790.8 CCF42371.1 - 0.0022 17.6 0.0 0.0025 17.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core TPR_10 PF13374.6 CCF42371.1 - 0.077 12.9 0.1 0.34 10.9 0.0 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat Glyco_hydro_53 PF07745.13 CCF42371.1 - 0.11 11.5 0.0 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 53 Pkinase PF00069.25 CCF42372.1 - 3e-17 62.9 0.0 5.9e-17 61.9 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF42372.1 - 0.00089 18.6 0.0 0.0015 17.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Spore_III_AB PF09548.10 CCF42373.1 - 0.033 14.3 0.9 0.5 10.5 0.1 2.4 2 0 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) SMC_ScpB PF04079.16 CCF42373.1 - 0.086 12.5 0.5 1.5 8.4 0.4 2.6 2 0 0 2 2 2 0 Segregation and condensation complex subunit ScpB DUF615 PF04751.14 CCF42373.1 - 0.29 11.1 2.1 0.3 11.1 0.4 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF615) MFS_1 PF07690.16 CCF42374.1 - 2.7e-14 52.8 33.9 2.7e-14 52.8 33.9 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily Claudin_3 PF06653.11 CCF42375.1 - 0.11 12.5 0.0 0.11 12.4 0.0 1.0 1 0 0 1 1 1 0 Tight junction protein, Claudin-like ODV-E18 PF10717.9 CCF42376.1 - 0.003 17.4 0.1 0.0048 16.7 0.1 1.4 1 0 0 1 1 1 1 Occlusion-derived virus envelope protein ODV-E18 Met_10 PF02475.16 CCF42377.1 - 3.3e-72 242.4 0.1 4.7e-72 241.9 0.1 1.2 1 0 0 1 1 1 1 Met-10+ like-protein TRM PF02005.16 CCF42377.1 - 0.047 12.9 0.0 0.093 11.9 0.0 1.4 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase DUF2871 PF11070.8 CCF42377.1 - 0.3 11.4 0.2 0.48 10.7 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2871) 2OG-FeII_Oxy_2 PF13532.6 CCF42378.1 - 4.8e-27 95.4 0.0 6.2e-27 95.1 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Prenyltransf PF01255.19 CCF42379.1 - 0.08 12.5 0.0 1.1 8.7 0.0 2.1 2 0 0 2 2 2 0 Putative undecaprenyl diphosphate synthase OCD_Mu_crystall PF02423.15 CCF42381.1 - 0.0018 17.3 0.0 0.18 10.7 0.0 2.1 2 0 0 2 2 2 2 Ornithine cyclodeaminase/mu-crystallin family DUF5494 PF17598.2 CCF42381.1 - 0.054 13.6 0.0 0.094 12.8 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5494) Formyl_trans_N PF00551.19 CCF42382.1 - 3.6e-40 137.6 0.0 4.2e-40 137.4 0.0 1.0 1 0 0 1 1 1 1 Formyl transferase MannoseP_isomer PF01050.18 CCF42382.1 - 0.031 14.1 0.3 0.057 13.3 0.1 1.5 2 0 0 2 2 2 0 Mannose-6-phosphate isomerase PBECR2 PF18810.1 CCF42382.1 - 0.06 13.6 0.0 0.1 12.9 0.0 1.5 1 0 0 1 1 1 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease2 Glyco_trans_4_4 PF13579.6 CCF42382.1 - 0.11 12.9 0.0 0.13 12.7 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase 4-like domain Cation_efflux PF01545.21 CCF42383.1 - 3.9e-22 79.0 10.6 5.2e-22 78.5 10.6 1.2 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 CCF42383.1 - 4.2e-08 33.2 0.0 8e-08 32.3 0.0 1.4 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter PI3_PI4_kinase PF00454.27 CCF42384.1 - 3.2e-39 135.3 0.1 4.8e-37 128.1 0.1 2.4 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 CCF42384.1 - 7.7e-23 80.9 0.0 2.1e-22 79.4 0.0 1.7 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) Proteasome PF00227.26 CCF42385.1 - 6.8e-27 94.2 0.3 2.3e-26 92.4 0.2 1.8 2 1 0 2 2 2 1 Proteasome subunit Sec63 PF02889.16 CCF42386.1 - 6.6e-82 274.5 0.0 9.1e-82 274.1 0.0 1.2 1 0 0 1 1 1 1 Sec63 Brl domain DEAD PF00270.29 CCF42386.1 - 6.7e-24 84.6 0.9 5.3e-12 45.9 0.2 3.6 5 0 0 5 5 5 2 DEAD/DEAH box helicase ResIII PF04851.15 CCF42386.1 - 5.6e-10 39.5 0.0 0.0003 20.8 0.0 2.7 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 CCF42386.1 - 6.4e-07 29.7 0.4 0.00014 22.1 0.0 3.8 2 2 0 2 2 2 1 Helicase conserved C-terminal domain AAA_30 PF13604.6 CCF42386.1 - 0.014 15.1 0.1 1.8 8.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 CCF42386.1 - 0.032 14.5 0.1 3.8 7.8 0.0 3.1 3 0 0 3 3 3 0 AAA domain AAA_19 PF13245.6 CCF42386.1 - 0.12 12.7 0.1 6.1 7.2 0.0 2.6 2 0 0 2 2 2 0 AAA domain Peptidase_S8 PF00082.22 CCF42387.1 - 4.4e-09 36.0 0.0 7.4e-09 35.3 0.0 1.4 1 0 0 1 1 1 1 Subtilase family PAN_4 PF14295.6 CCF42387.1 - 0.036 14.0 0.4 0.11 12.5 0.4 1.8 1 0 0 1 1 1 0 PAN domain NCKAP5 PF15246.6 CCF42388.1 - 0.0053 16.4 0.3 0.0062 16.2 0.3 1.0 1 0 0 1 1 1 1 Nck-associated protein 5, Peripheral clock protein FAD_binding_4 PF01565.23 CCF42390.1 - 1e-19 70.6 2.0 2.1e-19 69.7 2.0 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 CCF42390.1 - 0.00032 20.7 0.2 0.00073 19.6 0.2 1.6 1 0 0 1 1 1 1 Berberine and berberine like GMC_oxred_N PF00732.19 CCF42393.1 - 1e-53 182.6 0.0 1.3e-53 182.3 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCF42393.1 - 7.5e-38 130.3 0.0 1.2e-37 129.6 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 CCF42393.1 - 2.5e-07 30.1 0.1 0.016 14.3 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain Lycopene_cycl PF05834.12 CCF42393.1 - 5.3e-06 25.7 0.0 8.6e-06 25.0 0.0 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 CCF42393.1 - 3.2e-05 24.0 0.2 0.00034 20.8 0.1 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CCF42393.1 - 0.00026 20.7 0.4 0.0015 18.2 0.1 2.3 3 0 0 3 3 3 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCF42393.1 - 0.001 18.4 0.0 0.0034 16.7 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCF42393.1 - 0.0031 18.0 0.1 0.18 12.4 0.0 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 CCF42393.1 - 0.0049 15.8 0.2 0.011 14.6 0.0 1.6 2 0 0 2 2 2 1 Tryptophan halogenase FAD_oxidored PF12831.7 CCF42393.1 - 0.012 15.0 0.1 1.6 8.0 0.0 2.3 2 0 0 2 2 2 0 FAD dependent oxidoreductase Thi4 PF01946.17 CCF42393.1 - 0.058 12.6 0.0 0.15 11.3 0.0 1.6 2 0 0 2 2 2 0 Thi4 family HI0933_like PF03486.14 CCF42393.1 - 0.08 11.6 0.0 0.14 10.8 0.0 1.3 1 0 0 1 1 1 0 HI0933-like protein Methyltransf_23 PF13489.6 CCF42396.1 - 1.7e-13 50.8 0.0 3.1e-13 49.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF42396.1 - 6.1e-08 33.3 0.0 1.2e-07 32.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF42396.1 - 3.1e-06 27.7 0.0 6.2e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF42396.1 - 2.3e-05 24.2 0.0 0.00011 22.0 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF42396.1 - 0.00062 20.5 0.0 0.01 16.6 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain CheR PF01739.18 CCF42396.1 - 0.0038 16.7 0.0 0.006 16.1 0.0 1.2 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain Methyltransf_4 PF02390.17 CCF42396.1 - 0.17 11.3 0.0 1.5 8.3 0.0 2.0 2 0 0 2 2 2 0 Putative methyltransferase IF4E PF01652.18 CCF42397.1 - 2.2e-44 151.1 0.2 2.7e-44 150.8 0.2 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E RecO_N_2 PF13114.6 CCF42397.1 - 0.1 12.3 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 RecO N terminal UCH PF00443.29 CCF42398.1 - 1.8e-24 86.6 0.0 2.8e-24 86.0 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 CCF42398.1 - 2.9e-12 46.7 1.7 4.6e-12 46.1 0.4 1.9 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.6 CCF42398.1 - 0.012 15.2 0.1 0.055 13.0 0.1 2.1 1 1 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase CRISPR_assoc PF08798.11 CCF42398.1 - 0.16 12.1 0.1 0.92 9.6 0.1 2.0 2 0 0 2 2 2 0 CRISPR associated protein Utp13 PF08625.11 CCF42399.1 - 1.7e-50 170.6 0.5 2.7e-50 170.0 0.5 1.3 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain WD40 PF00400.32 CCF42399.1 - 1.2e-45 152.5 19.2 0.00036 21.3 0.5 11.7 11 1 0 11 11 11 9 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF42399.1 - 2.2e-11 43.9 5.3 0.43 10.9 0.3 8.2 6 2 2 8 8 8 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CCF42399.1 - 6.1e-06 25.2 1.5 0.16 10.5 0.0 4.9 4 2 0 5 5 5 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 CCF42399.1 - 0.095 11.4 3.3 14 4.2 0.0 4.6 6 1 0 7 7 7 0 Nup133 N terminal like VIR_N PF15912.5 CCF42400.1 - 0.12 12.0 7.2 0.24 11.0 7.2 1.4 1 0 0 1 1 1 0 Virilizer, N-terminal CAP_N PF01213.19 CCF42400.1 - 2.2 7.7 4.6 3.8 6.9 4.6 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal CENP-S PF15630.6 CCF42401.1 - 3.3e-35 120.3 0.0 4.7e-35 119.8 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 CCF42401.1 - 2.6e-06 27.5 0.0 2.8e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Bromo_TP PF07524.13 CCF42401.1 - 0.0007 19.5 0.0 0.0048 16.9 0.0 1.9 1 1 1 2 2 2 1 Bromodomain associated Histone PF00125.24 CCF42401.1 - 0.0078 16.6 0.0 0.0078 16.6 0.0 1.6 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 TFIID-18kDa PF02269.16 CCF42401.1 - 0.016 15.2 0.1 0.021 14.8 0.1 1.2 1 0 0 1 1 1 0 Transcription initiation factor IID, 18kD subunit DUF956 PF06115.11 CCF42401.1 - 0.036 13.8 0.0 0.061 13.0 0.0 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF956) TAF PF02969.17 CCF42401.1 - 0.059 13.6 0.0 0.12 12.6 0.0 1.5 1 0 0 1 1 1 0 TATA box binding protein associated factor (TAF) PGA2 PF07543.12 CCF42402.1 - 2.6e-37 127.9 0.3 3.1e-37 127.6 0.3 1.1 1 0 0 1 1 1 1 Protein trafficking PGA2 COMPASS-Shg1 PF05205.12 CCF42403.1 - 5.6e-27 94.4 0.1 5.6e-27 94.4 0.1 2.1 2 0 0 2 2 2 1 COMPASS (Complex proteins associated with Set1p) component shg1 Asp-B-Hydro_N PF05279.11 CCF42403.1 - 0.96 9.5 20.9 1.3 9.0 20.9 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region PDDEXK_6 PF04720.12 CCF42403.1 - 6.8 6.6 14.2 4.2 7.2 0.0 2.1 2 0 0 2 2 2 0 PDDEXK-like family of unknown function RR_TM4-6 PF06459.12 CCF42403.1 - 7.4 6.3 13.8 10 5.9 13.8 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 p450 PF00067.22 CCF42404.1 - 4.3e-13 48.8 0.0 4.9e-13 48.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 STIMATE PF12400.8 CCF42405.1 - 9e-18 65.0 3.2 1.1e-17 64.7 3.2 1.1 1 0 0 1 1 1 1 STIMATE family Peptidase_C12 PF01088.21 CCF42406.1 - 0.13 12.0 0.0 0.18 11.5 0.0 1.1 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase, family 1 Med29 PF11568.8 CCF42406.1 - 0.14 12.4 0.0 0.19 11.9 0.0 1.2 1 0 0 1 1 1 0 Mediator complex subunit 29 Hid1 PF12722.7 CCF42407.1 - 0.071 11.2 0.0 0.073 11.2 0.0 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PhoLip_ATPase_N PF16209.5 CCF42409.1 - 3.5e-16 58.7 0.4 7.3e-16 57.6 0.4 1.5 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.20 CCF42409.1 - 1.3e-06 28.0 5.4 0.00058 19.4 0.0 3.0 4 0 0 4 4 4 2 E1-E2 ATPase Cation_ATPase PF13246.6 CCF42409.1 - 0.00018 21.5 0.0 0.00041 20.4 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) p450 PF00067.22 CCF42410.1 - 4.6e-61 207.0 0.0 5.5e-61 206.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Zn_clus PF00172.18 CCF42411.1 - 4.7e-08 33.0 8.0 7e-08 32.5 8.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 CCF42411.1 - 0.0082 15.0 0.1 0.011 14.6 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Prot_inhib_II PF02428.15 CCF42411.1 - 0.34 11.4 4.6 0.71 10.4 4.6 1.5 1 0 0 1 1 1 0 Potato type II proteinase inhibitor family Opy2 PF09463.10 CCF42411.1 - 1.2 9.6 6.4 0.28 11.6 2.2 2.0 2 0 0 2 2 2 0 Opy2 protein Bax1-I PF01027.20 CCF42413.1 - 8.5e-53 179.3 26.5 9.8e-53 179.1 26.5 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 Spore_YhaL PF14147.6 CCF42413.1 - 0.16 11.7 0.8 0.69 9.6 0.1 2.4 2 0 0 2 2 2 0 Sporulation protein YhaL DUF3040 PF11239.8 CCF42413.1 - 3.1 8.1 5.7 2 8.7 0.1 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF3040) MBOAT_2 PF13813.6 CCF42414.1 - 1.3e-12 47.7 1.1 1.3e-12 47.7 1.1 2.6 3 1 0 3 3 3 1 Membrane bound O-acyl transferase family MAP65_ASE1 PF03999.12 CCF42415.1 - 3e-81 274.0 9.9 3e-81 274.0 9.9 1.3 1 1 0 1 1 1 1 Microtubule associated protein (MAP65/ASE1 family) HEPN_Cthe2314 PF18730.1 CCF42415.1 - 0.057 13.5 0.2 0.057 13.5 0.2 2.1 3 0 0 3 3 3 0 Cthe_2314-like HEPN YojJ PF10372.9 CCF42415.1 - 2.8 8.1 5.5 17 5.6 0.1 3.1 3 0 0 3 3 3 0 Bacterial membrane-spanning protein N-terminus Prominin PF05478.11 CCF42415.1 - 6.1 4.7 5.8 8.4 4.2 0.1 2.5 2 1 0 2 2 2 0 Prominin NAD_binding_8 PF13450.6 CCF42416.1 - 3.3e-06 27.2 0.9 1.3e-05 25.3 0.2 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 CCF42416.1 - 3.1e-05 24.0 0.0 0.0046 17.0 0.0 2.5 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox_3 PF13738.6 CCF42416.1 - 6e-05 22.4 0.0 0.00049 19.5 0.0 2.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CCF42416.1 - 8.5e-05 21.9 0.0 0.00019 20.8 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase 2-Hacid_dh_C PF02826.19 CCF42416.1 - 0.0008 18.8 0.0 0.0063 15.9 0.0 2.2 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 CCF42416.1 - 0.0018 18.4 0.0 0.47 10.5 0.0 2.3 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase K_oxygenase PF13434.6 CCF42416.1 - 0.005 16.0 0.0 0.0091 15.2 0.0 1.3 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) ThiF PF00899.21 CCF42416.1 - 0.0055 16.1 0.1 1 8.7 0.0 2.3 2 0 0 2 2 2 2 ThiF family MCRA PF06100.11 CCF42416.1 - 0.012 14.4 0.1 0.019 13.8 0.1 1.2 1 0 0 1 1 1 0 MCRA family DAO PF01266.24 CCF42416.1 - 2 7.9 8.3 0.25 10.9 3.3 1.9 1 1 0 1 1 1 0 FAD dependent oxidoreductase polyprenyl_synt PF00348.17 CCF42417.1 - 7.1e-65 218.6 0.0 1e-64 218.1 0.0 1.2 1 0 0 1 1 1 1 Polyprenyl synthetase Translin PF01997.16 CCF42417.1 - 0.055 13.4 0.0 0.13 12.2 0.0 1.6 1 1 0 2 2 2 0 Translin family adh_short PF00106.25 CCF42418.1 - 3.2e-30 105.1 0.0 2.7e-26 92.2 0.0 2.3 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCF42418.1 - 7.6e-19 68.2 0.0 1.4e-18 67.3 0.0 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF42418.1 - 5.6e-08 32.9 0.1 1e-07 32.1 0.1 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF42418.1 - 0.0019 17.7 0.1 0.0035 16.8 0.1 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CCF42418.1 - 0.0042 16.5 0.0 0.0062 16.0 0.0 1.4 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 CCF42418.1 - 0.017 15.0 0.8 0.054 13.4 0.4 2.1 2 1 0 2 2 2 0 NAD(P)H-binding NAD_binding_7 PF13241.6 CCF42418.1 - 0.084 13.3 0.0 0.3 11.5 0.0 1.9 2 1 0 2 2 2 0 Putative NAD(P)-binding DpaA_N PF16924.5 CCF42418.1 - 0.13 12.3 0.0 0.34 11.0 0.0 1.6 2 0 0 2 2 2 0 Dipicolinate synthase subunit A N-terminal domain UbiA PF01040.18 CCF42419.1 - 1.7e-34 119.3 13.9 2.3e-34 118.9 13.9 1.2 1 0 0 1 1 1 1 UbiA prenyltransferase family Sugar_tr PF00083.24 CCF42422.1 - 1e-06 27.9 5.2 1.2e-06 27.6 5.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF42422.1 - 1.5e-06 27.4 9.4 2.1e-06 26.9 9.4 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily RNA_POL_M_15KD PF02150.16 CCF42424.1 - 5.1e-12 45.5 3.0 5.1e-12 45.5 3.0 2.2 2 0 0 2 2 2 1 RNA polymerases M/15 Kd subunit GFA PF04828.14 CCF42424.1 - 0.7 10.3 0.1 0.7 10.3 0.1 2.2 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme Nudix_N_2 PF14803.6 CCF42424.1 - 4.8 7.2 13.5 0.11 12.4 1.6 3.0 3 0 0 3 3 3 0 Nudix N-terminal Rotamase PF00639.21 CCF42425.1 - 1.1e-23 84.0 0.1 1.5e-23 83.6 0.1 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.6 CCF42425.1 - 1.5e-16 60.9 0.0 2.2e-16 60.4 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain WW PF00397.26 CCF42425.1 - 3.2e-08 33.5 0.3 3.2e-08 33.5 0.3 1.7 2 0 0 2 2 2 1 WW domain Rotamase_2 PF13145.6 CCF42425.1 - 4.1e-05 24.4 0.0 5.9e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 PPIC-type PPIASE domain WW_1 PF18507.1 CCF42425.1 - 0.0023 17.6 0.1 0.004 16.8 0.1 1.4 1 0 0 1 1 1 1 WW domain Pkinase PF00069.25 CCF42428.1 - 2.7e-26 92.5 0.0 8e-26 91.0 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF42428.1 - 0.0032 16.8 0.0 0.026 13.8 0.0 2.3 3 0 0 3 3 3 1 Protein tyrosine kinase RPE65 PF03055.15 CCF42429.1 - 3.9e-91 306.6 0.0 4.7e-91 306.3 0.0 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein Peptidase_S28 PF05577.12 CCF42430.1 - 4e-06 25.9 0.0 4.8e-06 25.6 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase S28 ETC_C1_NDUFA4 PF04800.12 CCF42430.1 - 0.11 12.8 0.0 0.15 12.3 0.0 1.2 1 0 0 1 1 1 0 ETC complex I subunit conserved region Glyco_transf_8 PF01501.20 CCF42431.1 - 3.9e-24 85.6 0.6 8.5e-23 81.2 0.6 2.2 1 1 0 1 1 1 1 Glycosyl transferase family 8 Mannosyl_trans3 PF11051.8 CCF42431.1 - 0.015 14.7 0.0 0.025 13.9 0.0 1.3 1 0 0 1 1 1 0 Mannosyltransferase putative zf-rbx1 PF12678.7 CCF42432.1 - 2e-09 37.6 4.4 4.1e-09 36.6 4.4 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 CCF42432.1 - 2.5e-09 37.3 5.4 4.7e-09 36.4 5.4 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 CCF42432.1 - 6.2e-06 26.0 3.4 1.1e-05 25.2 3.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CCF42432.1 - 1.4e-05 25.0 2.7 2.7e-05 24.1 2.7 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 CCF42432.1 - 9e-05 22.4 2.7 0.00026 20.9 2.9 1.7 1 1 1 2 2 2 1 zinc-RING finger domain Zn_ribbon_17 PF17120.5 CCF42432.1 - 0.00028 20.4 0.3 0.00063 19.3 0.3 1.5 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-C3HC4_3 PF13920.6 CCF42432.1 - 0.00028 20.7 7.3 0.006 16.4 7.6 2.2 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 CCF42432.1 - 0.003 17.6 2.4 0.0075 16.3 2.4 1.6 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.6 CCF42432.1 - 0.0047 16.7 7.2 0.011 15.6 7.2 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CCF42432.1 - 0.0052 16.6 3.1 0.013 15.3 3.1 1.6 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 ACTL7A_N PF16840.5 CCF42432.1 - 0.011 15.8 0.2 0.054 13.6 0.2 2.2 1 0 0 1 1 1 0 Actin-like protein 7A N-terminus zf-RING_11 PF17123.5 CCF42432.1 - 0.038 13.7 1.2 0.14 11.9 1.2 2.0 1 1 0 1 1 1 0 RING-like zinc finger FANCL_C PF11793.8 CCF42432.1 - 0.12 12.6 2.3 0.43 10.8 2.3 1.9 1 1 0 1 1 1 0 FANCL C-terminal domain zf-C3HC4_4 PF15227.6 CCF42432.1 - 0.13 12.5 1.2 0.27 11.4 1.2 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 CCF42432.1 - 0.62 9.9 2.6 1.4 8.7 2.6 1.6 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain CMD PF02627.20 CCF42433.1 - 0.0011 18.9 0.0 0.0015 18.6 0.0 1.2 1 0 0 1 1 1 1 Carboxymuconolactone decarboxylase family MFS_1 PF07690.16 CCF42434.1 - 6e-18 64.9 38.8 1.9e-17 63.3 35.5 2.7 1 1 1 2 2 2 1 Major Facilitator Superfamily Zn_clus PF00172.18 CCF42435.1 - 2e-08 34.2 10.1 2e-08 34.2 10.1 1.6 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Cu_amine_oxidN2 PF02727.16 CCF42436.1 - 4.2e-10 39.7 0.0 9.5e-10 38.6 0.0 1.5 2 0 0 2 2 2 1 Copper amine oxidase, N2 domain DUF1454 PF07305.12 CCF42437.1 - 0.015 14.7 0.0 0.029 13.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1454) TRAM PF01938.20 CCF42437.1 - 0.099 12.6 0.0 0.19 11.7 0.0 1.4 1 0 0 1 1 1 0 TRAM domain Cyclin_N PF00134.23 CCF42438.1 - 1.2e-07 31.5 0.2 1.3e-07 31.4 0.2 1.2 1 0 0 1 1 1 1 Cyclin, N-terminal domain Mito_carr PF00153.27 CCF42439.1 - 1e-07 31.8 0.0 2.1e-07 30.8 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial carrier protein Fungal_trans_2 PF11951.8 CCF42441.1 - 0.0013 17.6 0.0 0.0031 16.4 0.0 1.5 2 0 0 2 2 2 1 Fungal specific transcription factor domain Aldolase_II PF00596.21 CCF42442.1 - 1.7e-43 148.7 0.0 2e-43 148.5 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain DUF647 PF04884.14 CCF42443.1 - 3.4e-96 321.5 0.4 4.7e-96 321.1 0.4 1.2 1 0 0 1 1 1 1 Vitamin B6 photo-protection and homoeostasis TauE PF01925.19 CCF42443.1 - 3.2 7.3 7.3 0.56 9.8 1.2 2.1 1 1 0 2 2 2 0 Sulfite exporter TauE/SafE Ribosomal_S3Ae PF01015.18 CCF42444.1 - 4.5e-84 281.1 1.5 5.5e-84 280.8 1.5 1.0 1 0 0 1 1 1 1 Ribosomal S3Ae family SUI1 PF01253.22 CCF42444.1 - 0.02 15.4 0.3 0.06 13.9 0.0 1.9 2 0 0 2 2 2 0 Translation initiation factor SUI1 TipAS PF07739.13 CCF42444.1 - 0.095 13.2 0.0 2.1 8.9 0.0 2.5 2 1 1 3 3 3 0 TipAS antibiotic-recognition domain NEMO PF11577.8 CCF42444.1 - 0.13 12.3 0.0 0.33 11.0 0.0 1.7 1 0 0 1 1 1 0 NF-kappa-B essential modulator NEMO Abhydro_lipase PF04083.16 CCF42444.1 - 0.14 11.7 0.0 0.29 10.8 0.0 1.5 1 0 0 1 1 1 0 Partial alpha/beta-hydrolase lipase region CDH-cyt PF16010.5 CCF42445.1 - 2.8e-34 118.4 0.9 9.1e-34 116.7 0.0 2.3 2 0 0 2 2 2 1 Cytochrome domain of cellobiose dehydrogenase SGL PF08450.12 CCF42445.1 - 0.00053 19.6 0.2 0.023 14.3 0.0 2.4 1 1 1 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region PD40 PF07676.12 CCF42445.1 - 0.00091 19.1 1.6 0.0017 18.2 0.3 2.3 2 0 0 2 2 2 1 WD40-like Beta Propeller Repeat Arylesterase PF01731.20 CCF42445.1 - 0.071 13.3 0.0 1.5 9.0 0.0 2.9 3 0 0 3 3 3 0 Arylesterase NHL PF01436.21 CCF42445.1 - 0.13 12.3 1.4 0.37 10.9 0.1 2.6 3 0 0 3 3 3 0 NHL repeat Aldo_ket_red PF00248.21 CCF42446.1 - 2.5e-55 187.8 0.0 3e-55 187.5 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family zf-C3HC4_3 PF13920.6 CCF42447.1 - 0.44 10.4 7.0 1.3 9.0 3.0 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) HgmA PF04209.13 CCF42448.1 - 3.1e-56 190.9 0.0 3.5e-56 190.7 0.0 1.0 1 0 0 1 1 1 1 homogentisate 1,2-dioxygenase EF-hand_1 PF00036.32 CCF42449.1 - 9e-27 90.6 13.2 2.4e-07 29.8 0.8 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 CCF42449.1 - 2.9e-23 82.1 14.3 3.1e-14 53.2 1.4 2.7 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 CCF42449.1 - 1.5e-20 71.3 6.6 4.6e-05 23.0 0.1 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 CCF42449.1 - 7.1e-18 63.2 11.0 1.7e-06 27.2 0.4 4.3 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 CCF42449.1 - 8.3e-13 48.0 12.6 0.00013 21.7 0.5 4.2 2 1 2 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 CCF42449.1 - 6.1e-07 29.8 0.1 0.0014 18.9 0.1 2.3 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 CCF42449.1 - 4.5e-06 26.6 8.1 0.0032 17.4 0.5 3.8 1 1 3 4 4 4 2 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 CCF42449.1 - 0.029 14.6 0.8 0.12 12.6 0.7 2.1 1 1 0 1 1 1 0 Dockerin type I domain EF-hand_9 PF14658.6 CCF42449.1 - 0.093 13.1 0.2 4.4 7.7 0.1 3.1 2 1 1 3 3 3 0 EF-hand domain SNF5 PF04855.12 CCF42450.1 - 1.4e-66 224.7 0.1 2.1e-65 220.8 0.1 2.2 1 1 0 1 1 1 1 SNF5 / SMARCB1 / INI1 ORC5_C PF14630.6 CCF42454.1 - 2.9e-53 181.2 0.0 3.2e-53 181.1 0.0 1.0 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus TPT PF03151.16 CCF42455.1 - 6.4e-57 193.1 10.1 7.7e-57 192.8 10.1 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 CCF42455.1 - 2.4e-11 43.9 30.9 1.3e-05 25.4 11.4 3.2 2 1 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 CCF42455.1 - 9.4e-06 25.0 15.6 0.00022 20.5 15.6 2.2 1 1 0 1 1 1 1 UAA transporter family PUNUT PF16913.5 CCF42455.1 - 0.014 14.6 10.6 0.024 13.9 10.3 1.4 1 1 0 1 1 1 0 Purine nucleobase transmembrane transport Metallophos PF00149.28 CCF42456.1 - 4.7e-34 118.7 0.0 7.3e-34 118.1 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 CCF42456.1 - 2.9e-17 62.9 0.0 5.2e-17 62.0 0.0 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Dus PF01207.17 CCF42457.1 - 2.9e-36 125.1 0.0 2.3e-26 92.6 0.0 2.7 2 1 0 2 2 2 2 Dihydrouridine synthase (Dus) zf_CCCH_4 PF18345.1 CCF42457.1 - 0.00073 19.5 8.8 0.12 12.5 0.6 3.4 3 0 0 3 3 3 2 Zinc finger domain zf-CCCH PF00642.24 CCF42457.1 - 0.68 9.9 9.4 0.99 9.4 0.1 2.9 3 0 0 3 3 3 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 CCF42457.1 - 5.9 6.8 12.6 0.27 11.1 1.4 3.1 3 0 0 3 3 3 0 CCCH-type zinc finger Bap31 PF05529.12 CCF42458.1 - 3e-49 166.4 10.2 4.1e-49 165.9 10.2 1.2 1 0 0 1 1 1 1 Bap31/Bap29 transmembrane region Bap31_Bap29_C PF18035.1 CCF42458.1 - 4.5e-16 58.6 7.1 8e-16 57.8 7.1 1.4 1 0 0 1 1 1 1 Bap31/Bap29 cytoplasmic coiled-coil domain CEP63 PF17045.5 CCF42458.1 - 0.0095 15.9 0.7 0.015 15.2 0.7 1.4 1 0 0 1 1 1 1 Centrosomal protein of 63 kDa DUF1079 PF06435.11 CCF42458.1 - 0.01 16.0 2.1 1.7 8.9 0.3 2.3 2 0 0 2 2 2 2 Repeat of unknown function (DUF1079) TolA_bind_tri PF16331.5 CCF42458.1 - 0.018 15.1 0.4 0.045 13.8 0.4 1.6 1 0 0 1 1 1 0 TolA binding protein trimerisation Csm1_N PF18504.1 CCF42458.1 - 0.032 14.6 2.2 0.064 13.6 1.8 1.6 1 1 0 1 1 1 0 Csm1 N-terminal domain TMF_DNA_bd PF12329.8 CCF42458.1 - 0.037 14.0 4.9 0.059 13.4 4.6 1.5 1 1 0 1 1 1 0 TATA element modulatory factor 1 DNA binding DUF192 PF02643.15 CCF42458.1 - 0.055 13.6 0.1 0.096 12.9 0.1 1.5 1 0 0 1 1 1 0 Uncharacterized ACR, COG1430 Spc7 PF08317.11 CCF42458.1 - 0.071 12.0 2.1 0.099 11.5 2.1 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DivIC PF04977.15 CCF42458.1 - 0.18 11.6 6.5 0.3 10.9 1.5 2.9 2 1 1 3 3 3 0 Septum formation initiator Cep57_MT_bd PF06657.13 CCF42458.1 - 0.23 12.0 4.2 0.47 11.0 0.3 2.3 1 1 1 2 2 2 0 Centrosome microtubule-binding domain of Cep57 DUF2956 PF11169.8 CCF42458.1 - 0.33 11.2 5.9 0.57 10.4 5.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2956) Peroxin-13_N PF04088.13 CCF42459.1 - 3.4e-51 173.3 0.0 4.7e-51 172.9 0.0 1.2 1 0 0 1 1 1 1 Peroxin 13, N-terminal region SH3_2 PF07653.17 CCF42459.1 - 4.8e-09 35.8 0.0 8.4e-09 35.0 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 CCF42459.1 - 2.8e-07 30.0 0.0 5.7e-07 29.0 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 CCF42459.1 - 2.9e-05 23.8 0.1 5.6e-05 22.9 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain AA_permease PF00324.21 CCF42460.1 - 5.1e-137 457.3 32.5 5.8e-137 457.2 32.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CCF42460.1 - 2e-35 122.5 35.8 2.5e-35 122.1 35.8 1.1 1 0 0 1 1 1 1 Amino acid permease SLATT_fungal PF18142.1 CCF42461.1 - 1.7e-24 86.1 0.0 3e-24 85.3 0.0 1.4 1 0 0 1 1 1 1 SMODS and SLOG-associating 2TM effector domain SLATT_1 PF18181.1 CCF42461.1 - 0.11 12.5 0.0 0.21 11.5 0.0 1.4 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 1 Abhydrolase_1 PF00561.20 CCF42462.1 - 2.2e-23 83.2 0.0 5e-23 82.1 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CCF42462.1 - 2.8e-15 56.2 0.0 5.8e-14 51.9 0.0 2.4 3 0 0 3 3 3 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CCF42462.1 - 1.9e-13 51.6 0.0 5.3e-13 50.1 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF915 PF06028.11 CCF42462.1 - 4.5e-07 29.5 0.0 1.1e-06 28.2 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) Esterase PF00756.20 CCF42462.1 - 5.2e-05 23.0 0.0 9.3e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 Putative esterase Ser_hydrolase PF06821.13 CCF42462.1 - 0.0053 16.6 0.0 0.01 15.7 0.0 1.4 1 0 0 1 1 1 1 Serine hydrolase Abhydrolase_3 PF07859.13 CCF42462.1 - 0.019 14.8 0.0 0.13 12.1 0.0 2.0 2 0 0 2 2 2 0 alpha/beta hydrolase fold Chlorophyllase2 PF12740.7 CCF42462.1 - 0.02 13.8 0.0 0.037 12.9 0.0 1.4 1 0 0 1 1 1 0 Chlorophyllase enzyme Peptidase_S15 PF02129.18 CCF42462.1 - 0.021 14.4 0.0 1.5 8.4 0.0 2.7 2 1 1 3 3 3 0 X-Pro dipeptidyl-peptidase (S15 family) LIDHydrolase PF10230.9 CCF42462.1 - 0.031 13.8 0.0 0.081 12.5 0.0 1.7 2 0 0 2 2 2 0 Lipid-droplet associated hydrolase Abhydrolase_5 PF12695.7 CCF42462.1 - 0.05 13.4 0.0 0.21 11.3 0.0 1.9 2 0 0 2 2 2 0 Alpha/beta hydrolase family Chlorophyllase PF07224.11 CCF42462.1 - 0.07 12.1 0.0 0.11 11.4 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase TPR_10 PF13374.6 CCF42462.1 - 0.092 12.6 0.2 0.2 11.5 0.2 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat Abhydrolase_2 PF02230.16 CCF42462.1 - 0.12 12.2 0.0 6.7 6.4 0.0 2.8 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase PGAP1 PF07819.13 CCF42462.1 - 0.15 11.8 0.0 0.24 11.1 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein MBOAT PF03062.19 CCF42463.1 - 1.3e-36 126.7 9.1 1.7e-36 126.3 9.1 1.1 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family MTHFR PF02219.17 CCF42465.1 - 1e-101 340.1 0.0 1.4e-101 339.6 0.0 1.1 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase Condensation PF00668.20 CCF42466.1 - 4.3e-12 45.5 0.0 5.9e-12 45.0 0.0 1.1 1 0 0 1 1 1 1 Condensation domain FANC_SAP PF18081.1 CCF42466.1 - 0.069 13.3 0.1 0.21 11.8 0.0 1.8 2 0 0 2 2 2 0 Fanconi anemia-associated nuclease SAP domain YchF-GTPase_C PF06071.13 CCF42467.1 - 9.9e-37 125.0 0.0 2.3e-36 123.8 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 CCF42467.1 - 6e-21 74.6 0.0 1.3e-20 73.6 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CCF42467.1 - 1e-07 31.6 0.0 1.9e-07 30.7 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B DUF1254 PF06863.12 CCF42468.1 - 1e-30 106.5 2.2 1.8e-30 105.7 0.8 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1254) DUF1214 PF06742.11 CCF42468.1 - 1.9e-19 70.1 0.1 5.4e-19 68.7 0.1 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF1214) Chitin_bind_1 PF00187.19 CCF42470.1 - 0.0034 17.8 15.3 0.0034 17.8 15.3 4.0 4 0 0 4 4 4 2 Chitin recognition protein TPP_enzyme_C PF02775.21 CCF42472.1 - 5.5e-26 91.2 0.2 2.3e-25 89.2 0.0 2.0 2 1 1 3 3 3 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 CCF42472.1 - 5.2e-24 84.5 0.0 8.1e-24 83.9 0.0 1.3 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain LIM PF00412.22 CCF42474.1 - 6.2e-21 74.4 17.8 6.5e-11 42.3 4.7 2.7 3 0 0 3 3 3 2 LIM domain C1_1 PF00130.22 CCF42474.1 - 6.8 6.7 11.6 1.5e+02 2.3 0.0 3.8 2 1 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Recep_L_domain PF01030.24 CCF42476.1 - 0.076 13.1 0.0 0.16 12.1 0.0 1.5 1 1 0 1 1 1 0 Receptor L domain G-patch PF01585.23 CCF42477.1 - 1e-12 47.7 0.3 2.2e-12 46.6 0.3 1.6 1 0 0 1 1 1 1 G-patch domain RRM_1 PF00076.22 CCF42477.1 - 4.5e-05 23.2 0.1 8e-05 22.4 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ferric_reduct PF01794.19 CCF42478.1 - 9.7e-19 67.7 14.2 2.5e-18 66.4 14.2 1.7 1 0 0 1 1 1 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 CCF42478.1 - 4.7e-14 52.8 0.0 6.6e-14 52.3 0.0 1.2 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 CCF42478.1 - 4e-07 30.1 0.2 1.6e-06 28.1 0.0 2.0 2 0 0 2 2 2 1 FAD-binding domain BPS1 PF05633.11 CCF42478.1 - 0.013 14.5 0.3 0.024 13.6 0.3 1.4 1 0 0 1 1 1 0 Protein BYPASS1-related DUF3446 PF11928.8 CCF42478.1 - 0.58 10.5 13.5 3.1 8.2 4.7 2.5 2 0 0 2 2 2 0 Early growth response N-terminal domain DUF373 PF04123.13 CCF42478.1 - 0.66 9.4 2.3 1.1 8.6 1.9 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF373) bZIP_1 PF00170.21 CCF42479.1 - 0.011 15.9 6.3 0.019 15.0 6.3 1.4 1 0 0 1 1 1 0 bZIP transcription factor bZIP_2 PF07716.15 CCF42479.1 - 2.3 8.3 12.1 0.36 10.9 8.1 1.7 2 0 0 2 2 2 0 Basic region leucine zipper Zip PF02535.22 CCF42479.1 - 3.9 6.6 6.6 3.8 6.6 6.6 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Creatinase_N PF01321.18 CCF42480.1 - 1.8e-08 35.1 0.0 2.1e-08 34.9 0.0 1.1 1 0 0 1 1 1 1 Creatinase/Prolidase N-terminal domain Importin_rep_3 PF18806.1 CCF42481.1 - 4.9e-05 23.3 0.0 0.00043 20.3 0.0 2.6 2 0 0 2 2 2 1 Importin 13 repeat Xpo1 PF08389.12 CCF42481.1 - 0.00077 19.5 0.2 0.0089 16.1 0.4 2.6 2 0 0 2 2 2 1 Exportin 1-like protein tRNA-synt_1b PF00579.25 CCF42482.1 - 1.7e-72 244.2 0.0 2.1e-72 243.9 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) Ribosomal_S10 PF00338.22 CCF42483.1 - 9.9e-25 86.6 0.0 1.5e-24 86.0 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e Fcf2 PF08698.11 CCF42484.1 - 1e-32 112.4 0.5 8.9e-32 109.4 0.0 2.2 1 1 1 2 2 2 1 Fcf2 pre-rRNA processing CBFD_NFYB_HMF PF00808.23 CCF42485.1 - 2.5e-19 69.3 0.5 3.8e-19 68.7 0.5 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 CCF42485.1 - 4e-15 56.3 0.1 7.4e-15 55.5 0.1 1.4 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Pol_alpha_B_N PF08418.10 CCF42485.1 - 0.029 14.3 0.1 0.034 14.1 0.1 1.2 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal CENP-X PF09415.10 CCF42485.1 - 0.045 14.1 0.0 0.074 13.4 0.0 1.3 1 0 0 1 1 1 0 CENP-S associating Centromere protein X Trypsin_2 PF13365.6 CCF42487.1 - 0.0095 16.8 0.0 0.15 12.9 0.0 2.6 2 1 0 2 2 2 1 Trypsin-like peptidase domain Peptidase_S64 PF08192.11 CCF42487.1 - 0.014 13.9 0.1 0.034 12.6 0.1 1.6 1 1 0 1 1 1 0 Peptidase family S64 Peptidase_S3 PF00944.19 CCF42487.1 - 0.015 15.1 0.0 0.026 14.4 0.0 1.3 1 0 0 1 1 1 0 Alphavirus core protein Peptidase_S32 PF05579.13 CCF42487.1 - 0.016 14.4 0.1 0.028 13.6 0.1 1.2 1 0 0 1 1 1 0 Equine arteritis virus serine endopeptidase S32 Pex16 PF08610.10 CCF42489.1 - 2e-139 464.3 0.1 2.3e-139 464.1 0.1 1.0 1 0 0 1 1 1 1 Peroxisomal membrane protein (Pex16) SRF-TF PF00319.18 CCF42490.1 - 1.3e-22 79.0 0.3 2.1e-22 78.3 0.3 1.3 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) Acetyltransf_1 PF00583.25 CCF42492.1 - 6.4e-07 29.6 0.0 9.9e-07 29.0 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CCF42492.1 - 2e-06 27.8 0.0 4.5e-06 26.6 0.0 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CCF42492.1 - 3.1e-06 27.5 0.0 6e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 CCF42492.1 - 3.2e-05 24.0 0.0 7.3e-05 22.8 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CCF42492.1 - 0.001 19.0 0.0 0.0018 18.2 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 CCF42492.1 - 0.0075 16.4 0.0 0.016 15.3 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase MFS_1 PF07690.16 CCF42495.1 - 0.002 17.1 3.4 0.013 14.5 0.7 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily BcrAD_BadFG PF01869.20 CCF42495.1 - 0.03 13.8 0.1 0.8 9.1 0.0 2.1 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family NTP_transf_7 PF07984.12 CCF42495.1 - 0.22 10.7 0.0 0.34 10.1 0.0 1.2 1 0 0 1 1 1 0 Nucleotidyltransferase Pkinase PF00069.25 CCF42496.1 - 2e-53 181.4 0.0 2.6e-53 181.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF42496.1 - 1.9e-31 109.3 0.0 2.4e-31 108.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF42496.1 - 4.4e-05 22.9 0.0 0.00045 19.6 0.0 2.0 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 CCF42496.1 - 0.00093 19.2 0.0 0.002 18.1 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 CCF42496.1 - 0.0039 16.6 0.0 0.0059 16.0 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 CCF42496.1 - 0.0094 14.8 0.0 0.012 14.4 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 CCF42496.1 - 0.039 12.9 0.0 0.056 12.4 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain FTA2 PF13095.6 CCF42496.1 - 0.057 13.0 0.0 0.48 10.0 0.0 2.0 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Fungal_trans_2 PF11951.8 CCF42497.1 - 1.1e-06 27.7 0.2 1.5e-06 27.3 0.2 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF42497.1 - 0.0002 21.4 2.3 0.00037 20.6 2.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ATP-synt_C PF00137.21 CCF42498.1 - 9.6e-29 99.5 29.9 1e-20 73.8 12.9 2.2 2 0 0 2 2 2 2 ATP synthase subunit C Chromo PF00385.24 CCF42499.1 - 2.5e-17 62.5 0.1 4.3e-17 61.8 0.1 1.4 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain AT_hook PF02178.19 CCF42499.1 - 0.77 9.8 22.0 0.18 11.7 3.2 3.9 3 0 0 3 3 3 0 AT hook motif PQ-loop PF04193.14 CCF42500.1 - 2e-21 75.5 3.3 6e-11 41.9 0.7 2.5 2 0 0 2 2 2 2 PQ loop repeat AMP-binding PF00501.28 CCF42502.1 - 2.5e-79 266.9 0.0 3.3e-79 266.5 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.25 CCF42502.1 - 1.3e-16 60.6 0.0 3.1e-16 59.5 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site Condensation PF00668.20 CCF42502.1 - 1.5e-11 43.7 0.0 3e-07 29.5 0.0 2.1 2 0 0 2 2 2 2 Condensation domain FliN_N PF16973.5 CCF42502.1 - 0.1 12.4 0.0 0.25 11.2 0.0 1.6 1 0 0 1 1 1 0 Flagellar motor switch protein FliN N-terminal HSP70 PF00012.20 CCF42506.1 - 5.8e-267 886.7 14.7 6.5e-267 886.6 14.7 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 CCF42506.1 - 1.6e-15 56.7 2.8 4.8e-13 48.6 0.4 2.4 2 1 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.16 CCF42506.1 - 0.00042 20.1 0.1 0.0015 18.3 0.0 2.0 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain Ploopntkinase3 PF18751.1 CCF42506.1 - 0.024 14.6 0.2 1.8 8.4 0.2 2.4 1 1 0 1 1 1 0 P-loop Nucleotide Kinase3 ApoLp-III PF07464.11 CCF42506.1 - 0.25 11.4 4.4 0.24 11.5 1.8 2.3 2 1 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) APG17 PF04108.12 CCF42508.1 - 6e-140 466.8 3.9 7e-140 466.6 3.9 1.0 1 0 0 1 1 1 1 Autophagy protein Apg17 DUF4358 PF14270.6 CCF42508.1 - 0.011 16.0 1.0 0.15 12.4 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4358) Tnp_22_trimer PF17489.2 CCF42508.1 - 0.037 14.0 0.3 0.13 12.2 0.3 2.0 1 0 0 1 1 1 0 L1 transposable element trimerization domain DASH_Hsk3 PF08227.11 CCF42508.1 - 0.071 13.5 0.1 0.31 11.4 0.1 2.1 1 0 0 1 1 1 0 DASH complex subunit Hsk3 like GLTSCR1 PF15249.6 CCF42508.1 - 0.08 13.4 1.4 0.87 10.1 0.1 2.8 2 0 0 2 2 2 0 Conserved region of unknown function on GLTSCR protein TMP_2 PF06791.13 CCF42508.1 - 0.43 10.2 5.2 0.53 9.9 0.0 2.3 2 0 0 2 2 2 0 Prophage tail length tape measure protein KxDL PF10241.9 CCF42508.1 - 1.4 9.3 4.0 4.9 7.5 0.1 3.0 3 0 0 3 3 3 0 Uncharacterized conserved protein DUF948 PF06103.11 CCF42508.1 - 1.6 9.0 9.6 2.9 8.2 0.6 3.4 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF948) YtxH PF12732.7 CCF42508.1 - 2.4 8.8 5.0 43 4.7 0.1 3.5 3 0 0 3 3 3 0 YtxH-like protein DUF4795 PF16043.5 CCF42508.1 - 2.8 7.5 10.7 4.4 6.8 0.5 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4795) BAR PF03114.18 CCF42508.1 - 5.8 6.5 10.4 5.9 6.5 2.2 2.8 2 2 0 2 2 2 0 BAR domain CCDC-167 PF15188.6 CCF42508.1 - 8.3 6.8 6.5 5.9 7.3 0.1 3.3 3 0 0 3 3 3 0 Coiled-coil domain-containing protein 167 CLZ PF16526.5 CCF42508.1 - 9.7 6.6 8.3 1.2 9.5 0.2 3.4 3 1 1 4 4 4 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Ank_2 PF12796.7 CCF42509.1 - 6.8e-16 58.6 0.1 2.6e-05 24.7 0.2 3.1 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CCF42509.1 - 1.4e-13 51.1 0.1 0.00028 21.4 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 CCF42509.1 - 1.8e-12 47.1 0.1 0.00012 22.4 0.1 4.1 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 CCF42509.1 - 5.2e-11 42.6 0.4 8.5e-06 26.0 0.1 3.1 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCF42509.1 - 9.5e-10 37.9 0.0 0.066 13.8 0.0 4.4 4 0 0 4 4 4 2 Ankyrin repeat KilA-N PF04383.13 CCF42509.1 - 7.3e-08 32.3 0.2 7.5e-07 29.0 0.2 2.5 1 1 0 1 1 1 1 KilA-N domain APG6_N PF17675.1 CCF42509.1 - 0.021 15.3 7.1 0.021 15.3 7.1 2.6 2 1 0 2 2 2 0 Apg6 coiled-coil region Dynactin_p22 PF07426.11 CCF42509.1 - 0.046 13.6 4.0 0.1 12.5 4.0 1.6 1 0 0 1 1 1 0 Dynactin subunit p22 DUF2802 PF10975.8 CCF42509.1 - 0.14 12.3 4.4 0.38 10.9 0.4 3.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2802) AAA_13 PF13166.6 CCF42509.1 - 0.17 10.5 9.5 0.055 12.1 5.4 1.9 1 1 1 2 2 2 0 AAA domain Siah-Interact_N PF09032.11 CCF42509.1 - 0.8 10.1 5.9 0.39 11.1 0.6 2.8 2 0 0 2 2 2 0 Siah interacting protein, N terminal DivIC PF04977.15 CCF42509.1 - 5.7 6.8 7.5 26 4.7 0.3 3.0 2 0 0 2 2 2 0 Septum formation initiator Arrestin_C PF02752.22 CCF42510.1 - 1.8e-15 57.6 0.0 1.8e-14 54.3 0.0 2.4 1 1 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 CCF42510.1 - 7e-07 29.4 0.1 0.014 15.5 0.0 2.4 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain PLAC8 PF04749.17 CCF42511.1 - 1.4e-23 83.7 8.4 1.8e-23 83.4 8.4 1.1 1 0 0 1 1 1 1 PLAC8 family GMC_oxred_N PF00732.19 CCF42512.1 - 2.8e-63 214.1 0.2 4.3e-63 213.4 0.1 1.4 2 0 0 2 2 2 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCF42512.1 - 9.9e-29 100.7 0.0 2.4e-28 99.5 0.0 1.7 1 0 0 1 1 1 1 GMC oxidoreductase DAO PF01266.24 CCF42512.1 - 6.3e-07 29.3 0.4 0.0024 17.5 0.1 2.5 2 0 0 2 2 2 2 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 CCF42512.1 - 6.5e-05 22.1 0.1 0.00013 21.1 0.1 1.5 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 CCF42512.1 - 6.7e-05 23.0 0.0 0.00033 20.8 0.0 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 CCF42512.1 - 0.00032 20.0 0.1 0.0006 19.1 0.1 1.4 1 0 0 1 1 1 1 Thi4 family FAD_binding_2 PF00890.24 CCF42512.1 - 0.00035 19.8 0.7 0.033 13.3 0.3 2.2 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_3 PF13738.6 CCF42512.1 - 0.0017 17.7 0.3 0.087 12.1 0.2 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CCF42512.1 - 0.01 15.1 0.2 0.051 12.8 0.1 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CCF42512.1 - 0.018 15.1 0.3 0.1 12.6 0.1 2.1 2 0 0 2 2 2 0 FAD-NAD(P)-binding HI0933_like PF03486.14 CCF42512.1 - 0.063 12.0 0.1 0.28 9.9 0.0 1.8 2 0 0 2 2 2 0 HI0933-like protein Pyr_redox PF00070.27 CCF42512.1 - 0.08 13.5 0.3 0.66 10.6 0.2 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase BCNT PF07572.12 CCF42515.1 - 1e-24 86.3 2.8 1.7e-24 85.7 2.8 1.3 1 0 0 1 1 1 1 Bucentaur or craniofacial development DSBA PF01323.20 CCF42516.1 - 2.7e-15 56.7 0.0 1.1e-06 28.5 0.0 2.1 2 0 0 2 2 2 2 DSBA-like thioredoxin domain adh_short PF00106.25 CCF42517.1 - 3.6e-27 95.1 0.0 1.8e-17 63.5 0.0 2.0 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCF42517.1 - 1.9e-19 70.2 0.1 6.1e-14 52.1 0.0 2.0 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF42517.1 - 7.1e-07 29.3 0.0 8.7e-07 29.0 0.0 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 CCF42517.1 - 0.001 19.0 0.0 0.0014 18.6 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CCF42517.1 - 0.0054 16.2 0.0 0.0068 15.9 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1776 PF08643.10 CCF42517.1 - 0.013 14.8 0.0 0.11 11.8 0.0 2.0 2 0 0 2 2 2 0 Fungal family of unknown function (DUF1776) NAD_binding_2 PF03446.15 CCF42517.1 - 0.019 15.1 0.0 0.025 14.7 0.0 1.2 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Peripla_BP_6 PF13458.6 CCF42517.1 - 0.027 14.1 0.1 0.027 14.1 0.1 1.2 1 0 0 1 1 1 0 Periplasmic binding protein THF_DHG_CYH_C PF02882.19 CCF42517.1 - 0.032 13.5 0.1 0.07 12.4 0.0 1.5 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Glyco_hydro_47 PF01532.20 CCF42518.1 - 7.4e-123 410.8 0.0 2.5e-67 227.8 0.0 2.0 1 1 1 2 2 2 2 Glycosyl hydrolase family 47 Glyco_hydro_76 PF03663.14 CCF42518.1 - 0.091 12.3 0.0 4.2 6.8 0.0 2.3 2 1 0 2 2 2 0 Glycosyl hydrolase family 76 MSA-2c PF12238.8 CCF42519.1 - 0.18 11.8 1.3 3.3 7.7 1.0 2.0 1 1 1 2 2 2 0 Merozoite surface antigen 2c MscL PF01741.18 CCF42520.1 - 6.1e-21 74.9 0.1 7.5e-21 74.7 0.1 1.1 1 0 0 1 1 1 1 Large-conductance mechanosensitive channel, MscL zf-BED PF02892.15 CCF42520.1 - 0.0016 18.4 2.1 0.0026 17.8 2.1 1.3 1 0 0 1 1 1 1 BED zinc finger zf-C3HC4_3 PF13920.6 CCF42520.1 - 0.027 14.3 1.6 0.042 13.7 1.6 1.2 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DZR PF12773.7 CCF42520.1 - 0.042 13.9 0.7 0.069 13.2 0.7 1.2 1 0 0 1 1 1 0 Double zinc ribbon C1_1 PF00130.22 CCF42520.1 - 0.048 13.6 1.9 0.072 13.0 1.9 1.3 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zinc_ribbon_2 PF13240.6 CCF42520.1 - 1.5 8.6 4.0 2.6 7.9 4.0 1.3 1 0 0 1 1 1 0 zinc-ribbon domain ArsA_ATPase PF02374.15 CCF42521.1 - 6.4e-92 308.0 0.0 8e-92 307.7 0.0 1.0 1 0 0 1 1 1 1 Anion-transporting ATPase AAA_31 PF13614.6 CCF42521.1 - 5.9e-14 52.4 0.0 1.9e-13 50.7 0.0 1.8 2 0 0 2 2 2 1 AAA domain CbiA PF01656.23 CCF42521.1 - 9.1e-13 48.4 0.0 1.3e-12 47.9 0.0 1.4 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ParA PF10609.9 CCF42521.1 - 2.6e-06 27.1 0.8 8.1e-05 22.2 0.7 2.5 2 1 0 2 2 2 1 NUBPL iron-transfer P-loop NTPase Fer4_NifH PF00142.18 CCF42521.1 - 4.2e-06 26.4 0.0 6.3e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family SRP54 PF00448.22 CCF42521.1 - 1.1e-05 25.2 0.0 0.00059 19.5 0.0 2.4 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain CBP_BcsQ PF06564.12 CCF42521.1 - 4.6e-05 23.0 0.0 0.00012 21.7 0.0 1.6 2 0 0 2 2 2 1 Cellulose biosynthesis protein BcsQ AAA_25 PF13481.6 CCF42521.1 - 0.041 13.5 0.3 0.096 12.3 0.3 1.7 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 CCF42521.1 - 0.046 14.1 0.0 0.077 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain PhoH PF02562.16 CCF42521.1 - 0.07 12.6 0.0 0.13 11.6 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein Zeta_toxin PF06414.12 CCF42521.1 - 0.085 12.1 0.0 0.15 11.3 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin NB-ARC PF00931.22 CCF42521.1 - 0.1 11.8 0.0 0.16 11.1 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain IstB_IS21 PF01695.17 CCF42521.1 - 0.15 11.8 0.0 0.26 11.0 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_18 PF13238.6 CCF42521.1 - 0.16 12.5 0.0 0.34 11.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain RPN1_RPN2_N PF17781.1 CCF42522.1 - 0.16 11.3 0.2 0.21 10.9 0.2 1.1 1 0 0 1 1 1 0 RPN1/RPN2 N-terminal domain PDZ_1 PF12812.7 CCF42524.1 - 7.9e-54 179.6 0.0 5e-35 119.4 0.0 2.6 2 0 0 2 2 2 2 PDZ-like domain Trypsin_2 PF13365.6 CCF42524.1 - 8.6e-23 81.9 2.1 3.1e-20 73.6 0.1 2.5 2 0 0 2 2 2 2 Trypsin-like peptidase domain PDZ_6 PF17820.1 CCF42524.1 - 1.5e-13 50.3 0.0 3.3e-05 23.7 0.3 3.7 3 0 0 3 3 3 3 PDZ domain PDZ_2 PF13180.6 CCF42524.1 - 3.7e-13 49.6 2.6 6e-05 23.3 0.1 4.5 4 0 0 4 4 4 3 PDZ domain PDZ PF00595.24 CCF42524.1 - 9.2e-10 38.7 0.0 9.5e-05 22.7 0.0 3.7 3 0 0 3 3 3 2 PDZ domain Tricorn_PDZ PF14685.6 CCF42524.1 - 0.00044 20.2 0.5 0.028 14.4 0.2 3.4 3 0 0 3 3 3 1 Tricorn protease PDZ domain Trypsin PF00089.26 CCF42524.1 - 0.0019 18.0 0.0 0.007 16.2 0.0 2.0 2 1 0 2 2 2 1 Trypsin 4HPAD_g_N PF18671.1 CCF42524.1 - 0.0088 15.7 0.0 0.033 13.9 0.0 2.0 1 0 0 1 1 1 1 4-Hydroxyphenylacetate decarboxylase subunit gamma N-terminal Peptidase_S46 PF10459.9 CCF42524.1 - 0.19 10.3 0.2 0.38 9.3 0.2 1.4 1 0 0 1 1 1 0 Peptidase S46 Myb_DNA-binding PF00249.31 CCF42525.1 - 0.014 15.6 0.0 0.024 14.8 0.0 1.4 1 0 0 1 1 1 0 Myb-like DNA-binding domain SAPS PF04499.15 CCF42525.1 - 1.4 7.6 4.1 1.4 7.7 4.1 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF2981 PF11200.8 CCF42525.1 - 2.2 8.0 5.5 2.8 7.6 5.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) Pneumo_att_G PF05539.11 CCF42525.1 - 9.9 5.6 9.0 13 5.3 9.0 1.1 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G DnaJ PF00226.31 CCF42526.1 - 2.5e-22 78.8 1.6 4.9e-22 77.8 1.6 1.5 1 0 0 1 1 1 1 DnaJ domain zf-RING_2 PF13639.6 CCF42527.1 - 1.6e-08 34.8 9.3 3.1e-08 33.8 9.3 1.5 1 0 0 1 1 1 1 Ring finger domain FANCL_C PF11793.8 CCF42527.1 - 7.1e-06 26.1 8.9 2.1e-05 24.6 8.9 1.8 1 1 0 1 1 1 1 FANCL C-terminal domain zf-ANAPC11 PF12861.7 CCF42527.1 - 0.00036 20.5 3.0 0.00088 19.3 3.0 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 CCF42527.1 - 0.00069 19.9 8.4 0.0016 18.7 8.4 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain C1_1 PF00130.22 CCF42527.1 - 0.0018 18.1 3.9 0.0018 18.1 3.9 1.8 1 1 1 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-C3HC4 PF00097.25 CCF42527.1 - 0.0027 17.5 10.6 0.0053 16.6 10.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) RINGv PF12906.7 CCF42527.1 - 0.0052 16.9 8.3 0.012 15.8 8.3 1.6 1 0 0 1 1 1 1 RING-variant domain Zn_ribbon_17 PF17120.5 CCF42527.1 - 0.015 14.9 5.6 0.029 14.0 5.6 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-C3HC4_3 PF13920.6 CCF42527.1 - 0.046 13.6 6.2 0.087 12.7 6.2 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CCF42527.1 - 0.057 13.3 9.1 0.11 12.3 9.1 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING-like PF08746.11 CCF42527.1 - 0.13 12.6 8.6 0.24 11.7 8.6 1.5 1 0 0 1 1 1 0 RING-like domain Prok-RING_4 PF14447.6 CCF42527.1 - 0.34 10.8 5.4 0.79 9.6 5.4 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_9 PF13901.6 CCF42527.1 - 0.34 10.8 7.0 0.94 9.4 7.0 1.7 1 0 0 1 1 1 0 Putative zinc-RING and/or ribbon Zf_RING PF16744.5 CCF42527.1 - 1.6 8.9 4.4 5.6 7.1 4.4 1.9 1 0 0 1 1 1 0 KIAA1045 RING finger PHD PF00628.29 CCF42527.1 - 2 8.4 7.8 4.1 7.4 7.8 1.6 1 0 0 1 1 1 0 PHD-finger zf-RING_UBOX PF13445.6 CCF42527.1 - 2.8 8.0 6.2 6.4 6.9 6.2 1.6 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_4 PF14570.6 CCF42527.1 - 9.6 6.1 7.9 1.7e+02 2.1 7.9 2.4 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain HypA PF01155.19 CCF42528.1 - 0.052 13.6 1.8 0.07 13.2 1.8 1.3 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Pkinase PF00069.25 CCF42529.1 - 8.9e-35 120.3 0.0 1.3e-34 119.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF42529.1 - 1.2e-07 31.3 0.0 2e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CCF42529.1 - 0.0036 17.2 0.1 1.2 9.0 0.0 2.5 1 1 1 2 2 2 2 Phosphotransferase enzyme family KIX_2 PF16987.5 CCF42529.1 - 0.011 15.7 1.4 0.022 14.8 1.0 1.6 2 0 0 2 2 2 0 KIX domain muHD PF10291.9 CCF42530.1 - 5.7e-73 245.6 0.0 8.2e-73 245.1 0.0 1.2 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain FCH PF00611.23 CCF42530.1 - 8.5e-07 29.2 0.3 3.2e-06 27.3 0.0 2.2 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain LON_substr_bdg PF02190.16 CCF42530.1 - 0.11 12.4 0.4 0.21 11.4 0.4 1.5 1 0 0 1 1 1 0 ATP-dependent protease La (LON) substrate-binding domain Muted PF14942.6 CCF42530.1 - 0.2 12.0 9.3 0.16 12.3 5.4 2.6 3 0 0 3 3 3 0 Organelle biogenesis, Muted-like protein MAD PF05557.13 CCF42531.1 - 5.3e-63 213.4 61.4 2.2e-62 211.4 61.5 1.7 1 1 0 1 1 1 1 Mitotic checkpoint protein Tam41_Mmp37 PF09139.11 CCF42532.1 - 2.1e-125 418.5 0.0 2.6e-125 418.2 0.0 1.1 1 0 0 1 1 1 1 Phosphatidate cytidylyltransferase, mitochondrial FA_desaturase PF00487.24 CCF42533.1 - 7.5e-09 35.8 11.3 1.2e-08 35.1 11.3 1.3 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 CCF42533.1 - 9.1e-08 32.1 0.0 1.8e-07 31.2 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain HTH_psq PF05225.16 CCF42534.1 - 6.3e-11 41.8 0.0 1.4e-10 40.8 0.0 1.6 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.16 CCF42534.1 - 1.1e-08 34.9 0.1 2.8e-08 33.7 0.0 1.7 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_23 PF13384.6 CCF42534.1 - 0.0022 17.7 0.1 0.033 14.0 0.0 2.6 2 1 1 3 3 3 1 Homeodomain-like domain HTH_28 PF13518.6 CCF42534.1 - 0.0035 17.4 0.1 0.25 11.5 0.0 2.7 3 0 0 3 3 3 1 Helix-turn-helix domain Pectate_lyase PF03211.13 CCF42536.1 - 2.9e-61 206.6 9.3 3.6e-61 206.2 9.3 1.0 1 0 0 1 1 1 1 Pectate lyase DIM PF08194.12 CCF42536.1 - 0.13 12.5 2.3 0.33 11.2 0.2 2.4 2 0 0 2 2 2 0 DIM protein RecQ_Zn_bind PF16124.5 CCF42537.1 - 1.5e-05 25.6 2.4 1.6e-05 25.5 0.3 2.2 2 0 0 2 2 2 1 RecQ zinc-binding PTRF_SDPR PF15237.6 CCF42537.1 - 0.027 14.1 0.2 0.041 13.5 0.2 1.3 1 0 0 1 1 1 0 PTRF/SDPR family Sugar_tr PF00083.24 CCF42538.1 - 3.1e-99 332.9 22.7 3.6e-99 332.7 22.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF42538.1 - 2.3e-31 109.0 34.2 1.4e-22 80.1 8.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 CCF42538.1 - 0.0016 16.9 1.9 0.0016 16.9 1.9 2.1 2 0 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family MFS_3 PF05977.13 CCF42538.1 - 0.043 12.2 5.7 1.2 7.4 1.0 2.1 2 0 0 2 2 2 0 Transmembrane secretion effector DUF2530 PF10745.9 CCF42538.1 - 9.8 6.5 8.7 0.92 9.8 0.4 3.2 3 1 0 3 3 3 0 Protein of unknown function (DUF2530) CTP_transf_like PF01467.26 CCF42541.1 - 5.5e-29 101.2 0.0 9.3e-29 100.5 0.0 1.4 1 0 0 1 1 1 1 Cytidylyltransferase-like OPT PF03169.15 CCF42542.1 - 1.8e-167 558.7 55.1 2.1e-167 558.5 55.1 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF2427 PF10348.9 CCF42542.1 - 4.9 7.0 9.6 0.2 11.4 1.0 3.3 4 1 0 4 4 4 0 Domain of unknown function (DUF2427) DUF5523 PF17661.1 CCF42543.1 - 0.64 9.7 17.6 0.37 10.4 1.6 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5523) Sec62 PF03839.16 CCF42543.1 - 9.8 5.6 9.9 0.37 10.3 1.7 2.2 2 0 0 2 2 2 0 Translocation protein Sec62 ADK PF00406.22 CCF42545.1 - 1e-23 84.1 0.0 1.7e-23 83.4 0.0 1.3 1 0 0 1 1 1 1 Adenylate kinase HD_3 PF13023.6 CCF42545.1 - 1.7e-18 67.1 0.0 2.8e-18 66.4 0.0 1.3 1 0 0 1 1 1 1 HD domain AAA_17 PF13207.6 CCF42545.1 - 6.6e-17 62.2 0.0 1.2e-16 61.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CCF42545.1 - 0.00075 20.0 0.0 0.002 18.6 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 CCF42545.1 - 0.0021 18.5 0.0 0.0059 17.0 0.0 1.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CCF42545.1 - 0.0021 18.5 0.0 0.0048 17.3 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain HD PF01966.22 CCF42545.1 - 0.0031 17.7 0.2 0.0077 16.5 0.2 1.8 1 1 0 1 1 1 1 HD domain HD_2 PF12917.7 CCF42545.1 - 0.0063 16.3 0.0 0.012 15.3 0.0 1.5 1 1 0 1 1 1 1 HD containing hydrolase-like enzyme Zeta_toxin PF06414.12 CCF42545.1 - 0.02 14.2 0.0 0.055 12.7 0.0 1.7 2 0 0 2 2 2 0 Zeta toxin RuvB_N PF05496.12 CCF42545.1 - 0.024 14.4 0.0 0.039 13.7 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Thymidylate_kin PF02223.17 CCF42545.1 - 0.064 12.9 0.0 0.26 10.9 0.0 1.8 2 0 0 2 2 2 0 Thymidylate kinase NTPase_1 PF03266.15 CCF42545.1 - 0.064 13.2 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 NTPase E1_4HB PF16191.5 CCF42545.1 - 0.069 13.3 0.4 11 6.3 0.0 2.3 2 0 0 2 2 2 0 Ubiquitin-activating enzyme E1 four-helix bundle AAA_19 PF13245.6 CCF42545.1 - 0.095 13.0 0.0 0.18 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 CCF42545.1 - 0.15 12.2 0.0 0.78 9.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 CCF42545.1 - 0.2 11.5 0.0 0.38 10.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Fungal_trans_2 PF11951.8 CCF42547.1 - 2.1e-05 23.6 0.3 3.6e-05 22.8 0.3 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF42547.1 - 0.1 12.7 13.8 0.11 12.6 4.5 2.6 2 0 0 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_transf_28 PF03033.20 CCF42548.1 - 1e-23 83.9 0.0 1.7e-23 83.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain PUB_1 PF18486.1 CCF42549.1 - 0.064 13.1 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 PNGase/UBA- or UBX-containing domain Alg14 PF08660.11 CCF42550.1 - 1.3e-30 106.6 0.0 1.5e-30 106.5 0.0 1.0 1 0 0 1 1 1 1 Oligosaccharide biosynthesis protein Alg14 like MRP-S25 PF13741.6 CCF42551.1 - 6.8e-65 218.8 5.9 1.6e-57 194.7 2.0 2.0 1 1 1 2 2 2 2 Mitochondrial ribosomal protein S25 DUF5457 PF17540.2 CCF42551.1 - 0.09 12.9 0.8 0.18 11.9 0.8 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5457) ADK PF00406.22 CCF42554.1 - 2.6e-22 79.5 0.0 3.4e-22 79.2 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 CCF42554.1 - 9.6e-19 68.2 0.0 1.3e-18 67.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 CCF42554.1 - 0.12 12.5 0.0 0.2 11.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain Glyco_hydro_72 PF03198.14 CCF42556.1 - 7.5e-124 413.1 5.1 9.6e-124 412.7 5.1 1.0 1 0 0 1 1 1 1 Glucanosyltransferase Cellulase PF00150.18 CCF42556.1 - 4.9e-05 22.9 0.9 0.00089 18.8 0.9 2.3 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) RNase_H2-Ydr279 PF09468.10 CCF42557.1 - 1.5e-43 148.7 3.0 1.3e-42 145.7 0.1 2.5 2 1 0 2 2 2 1 Ydr279p protein family (RNase H2 complex component) wHTH domain Ydr279_N PF17745.1 CCF42557.1 - 5.6e-24 84.2 0.6 1.6e-23 82.8 0.0 2.1 2 0 0 2 2 2 1 Ydr279p protein triple barrel domain DUF1682 PF07946.14 CCF42557.1 - 0.2 10.8 10.3 0.43 9.8 10.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) DASH_Duo1 PF08651.10 CCF42558.1 - 2.6e-31 107.2 0.3 3.7e-31 106.7 0.3 1.2 1 0 0 1 1 1 1 DASH complex subunit Duo1 DUF1682 PF07946.14 CCF42558.1 - 0.053 12.7 3.0 0.058 12.6 3.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) API5 PF05918.11 CCF42558.1 - 0.21 10.4 4.4 0.23 10.3 4.4 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) Myb_Cef PF11831.8 CCF42558.1 - 6.2 6.3 13.6 0.37 10.3 6.7 2.0 2 0 0 2 2 2 0 pre-mRNA splicing factor component SWIRM PF04433.17 CCF42559.1 - 1.7e-12 47.5 0.0 3.3e-12 46.6 0.0 1.4 1 0 0 1 1 1 1 SWIRM domain ADH_zinc_N_2 PF13602.6 CCF42560.1 - 9.6e-30 104.4 0.3 1.6e-29 103.6 0.3 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 CCF42560.1 - 2.1e-15 56.8 1.2 5e-15 55.6 0.6 2.0 1 1 1 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCF42560.1 - 5.2e-06 26.3 0.4 9.3e-05 22.3 0.0 2.6 2 2 1 3 3 3 1 Alcohol dehydrogenase GroES-like domain CytB6-F_Fe-S PF08802.10 CCF42560.1 - 3 8.0 5.1 2.9 8.0 2.2 2.5 2 0 0 2 2 2 0 Cytochrome B6-F complex Fe-S subunit Pkinase PF00069.25 CCF42562.1 - 4e-16 59.2 0.0 3.9e-12 46.1 0.0 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCF42562.1 - 0.00026 20.4 0.0 0.00058 19.2 0.0 1.6 1 1 1 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 CCF42562.1 - 0.0068 15.8 0.1 0.01 15.2 0.1 1.4 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CCF42562.1 - 0.017 15.1 0.2 0.032 14.2 0.2 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family RIO1 PF01163.22 CCF42562.1 - 0.13 11.9 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 RIO1 family DDE_1 PF03184.19 CCF42563.1 - 1.9e-25 89.6 0.0 2.8e-25 89.0 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_psq PF05225.16 CCF42563.1 - 1.8e-07 30.8 0.1 3.9e-07 29.7 0.1 1.6 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.16 CCF42563.1 - 0.00013 22.0 0.0 0.00033 20.6 0.0 1.8 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DDE_3 PF13358.6 CCF42563.1 - 0.00048 19.9 0.0 0.0049 16.6 0.0 2.1 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_AsnC-type PF13404.6 CCF42563.1 - 0.012 15.5 0.0 0.028 14.2 0.0 1.6 1 0 0 1 1 1 0 AsnC-type helix-turn-helix domain HTH_23 PF13384.6 CCF42563.1 - 0.022 14.6 0.0 0.06 13.2 0.0 1.7 1 0 0 1 1 1 0 Homeodomain-like domain IF-2B PF01008.17 CCF42564.1 - 3.4e-19 69.1 0.0 5.5e-19 68.4 0.0 1.3 1 0 0 1 1 1 1 Initiation factor 2 subunit family NUDIX PF00293.28 CCF42564.1 - 8e-13 48.6 0.1 1.9e-12 47.4 0.1 1.6 1 0 0 1 1 1 1 NUDIX domain BacA PF02673.18 CCF42565.1 - 0.0086 15.8 0.5 0.068 12.9 0.0 2.0 2 0 0 2 2 2 1 Bacitracin resistance protein BacA MNHE PF01899.16 CCF42565.1 - 0.026 14.3 0.2 1.3 8.7 0.0 2.1 2 0 0 2 2 2 0 Na+/H+ ion antiporter subunit CD20 PF04103.15 CCF42565.1 - 0.055 13.5 1.3 0.57 10.2 2.0 1.9 2 0 0 2 2 2 0 CD20-like family Ribosomal_L30_N PF08079.12 CCF42566.1 - 4.5e-25 87.7 16.0 7.3e-25 87.0 16.0 1.3 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Ribosomal_L30 PF00327.20 CCF42566.1 - 2.8e-16 59.1 2.3 2.8e-16 59.1 2.3 1.7 2 0 0 2 2 2 1 Ribosomal protein L30p/L7e DUF1943 PF09172.11 CCF42566.1 - 0.041 13.1 2.0 0.055 12.7 2.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1943) Ribosomal_S11 PF00411.19 CCF42567.1 - 1.7e-46 157.2 1.1 2.1e-46 156.9 1.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 CBM_25 PF03423.13 CCF42567.1 - 0.089 13.1 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 Carbohydrate binding domain (family 25) SNF2_N PF00176.23 CCF42568.1 - 1.2e-65 221.5 0.1 2.1e-65 220.8 0.1 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CCF42568.1 - 1.9e-17 63.6 0.0 5.6e-17 62.1 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCF42568.1 - 1.1e-09 38.5 0.1 3.3e-09 37.0 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Tannase PF07519.11 CCF42568.1 - 0.11 11.4 0.3 0.3 9.9 0.1 1.8 2 0 0 2 2 2 0 Tannase and feruloyl esterase DUF1803 PF08820.10 CCF42568.1 - 0.88 9.6 3.0 1.4 9.0 0.7 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF1803) ABC_tran_CTD PF16326.5 CCF42568.1 - 1 9.7 9.7 1.7 8.9 8.5 2.1 1 1 0 1 1 1 0 ABC transporter C-terminal domain NAM-associated PF14303.6 CCF42568.1 - 7.3 7.3 17.6 17 6.1 4.9 2.6 2 0 0 2 2 2 0 No apical meristem-associated C-terminal domain ApbA_C PF08546.11 CCF42569.1 - 2.2e-14 53.7 0.0 2.3e-14 53.7 0.0 1.0 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal MFS_1 PF07690.16 CCF42570.1 - 3.3e-39 134.8 22.1 3.3e-39 134.8 22.1 2.7 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF42570.1 - 9.8e-14 51.1 12.5 9.8e-14 51.1 12.5 2.8 2 1 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 CCF42570.1 - 0.0059 15.1 3.8 0.01 14.3 3.8 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) AMP-binding PF00501.28 CCF42571.1 - 1.3e-53 182.2 0.0 1.7e-53 181.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme HLH PF00010.26 CCF42572.1 - 1.8e-12 47.0 0.2 2.9e-12 46.3 0.2 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain MCU PF04678.13 CCF42573.1 - 2.8e-23 82.9 0.3 2.8e-23 82.9 0.3 1.6 2 0 0 2 2 2 1 Mitochondrial calcium uniporter p450 PF00067.22 CCF42574.1 - 9.2e-29 100.5 0.0 1.1e-28 100.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 adh_short PF00106.25 CCF42575.1 - 2.4e-25 89.1 0.1 1.1e-18 67.4 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCF42575.1 - 1.7e-16 60.5 0.2 1.9e-14 53.8 0.2 2.1 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF42575.1 - 4.4e-09 36.5 0.0 9.2e-09 35.5 0.0 1.5 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF42575.1 - 4.6e-05 23.0 0.0 8.6e-05 22.1 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 CCF42575.1 - 0.00056 19.1 0.0 0.0014 17.8 0.0 1.6 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein DUF1593 PF07632.11 CCF42576.1 - 1.1e-87 293.7 0.0 1.5e-87 293.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1593) REJ PF02010.15 CCF42576.1 - 0.02 13.7 0.0 0.026 13.3 0.0 1.1 1 0 0 1 1 1 0 REJ domain Pet127 PF08634.10 CCF42577.1 - 5.5e-120 399.9 2.2 8.7e-120 399.3 2.2 1.3 1 0 0 1 1 1 1 Mitochondrial protein Pet127 PDGLE PF13190.6 CCF42577.1 - 0.043 13.7 3.4 0.88 9.5 0.3 3.2 3 0 0 3 3 3 0 PDGLE domain NACHT_N PF17100.5 CCF42577.1 - 4.2 7.2 6.7 11 5.8 3.0 2.6 2 1 1 3 3 3 0 N-terminal domain of NWD NACHT-NTPase PGA2 PF07543.12 CCF42580.1 - 0.1 12.6 0.0 0.13 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein trafficking PGA2 FIIND PF13553.6 CCF42581.1 - 0.056 12.8 0.1 0.063 12.7 0.1 1.0 1 0 0 1 1 1 0 Function to find HATPase_c PF02518.26 CCF42582.1 - 4.3e-31 107.7 0.1 1.4e-30 106.1 0.1 1.9 2 0 0 2 2 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CCF42582.1 - 3.8e-19 68.5 0.2 1.5e-18 66.5 0.2 2.2 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain Response_reg PF00072.24 CCF42582.1 - 4.6e-15 55.7 0.2 1.9e-14 53.8 0.2 2.1 1 1 0 1 1 1 1 Response regulator receiver domain GAF_2 PF13185.6 CCF42582.1 - 9.2e-14 51.9 0.0 3.4e-13 50.1 0.0 2.0 1 0 0 1 1 1 1 GAF domain AAA_16 PF13191.6 CCF42582.1 - 2.8e-13 50.6 0.7 1.1e-12 48.6 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain Pkinase PF00069.25 CCF42582.1 - 5.7e-09 35.7 0.0 3.5e-08 33.2 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain GAF PF01590.26 CCF42582.1 - 1.7e-07 31.9 0.0 4.8e-07 30.5 0.0 1.9 1 0 0 1 1 1 1 GAF domain HATPase_c_3 PF13589.6 CCF42582.1 - 0.00016 21.5 0.0 0.00036 20.4 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase GAF_3 PF13492.6 CCF42582.1 - 0.0011 19.3 0.0 0.0031 17.9 0.0 1.9 1 0 0 1 1 1 1 GAF domain TPR_12 PF13424.6 CCF42582.1 - 0.0079 16.5 15.7 0.13 12.5 0.1 3.6 4 0 0 4 4 3 2 Tetratricopeptide repeat Pkinase_Tyr PF07714.17 CCF42582.1 - 0.076 12.3 0.0 0.15 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein tyrosine kinase NACHT PF05729.12 CCF42582.1 - 0.17 11.8 0.0 6.1 6.7 0.0 2.6 2 0 0 2 2 2 0 NACHT domain TPR_6 PF13174.6 CCF42582.1 - 0.26 12.0 0.9 8.7 7.2 0.2 3.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 CCF42582.1 - 0.36 11.2 3.7 34 5.0 0.1 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 CCF42582.1 - 0.42 10.9 10.4 1.3 9.3 0.2 4.3 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 CCF42582.1 - 1.1 9.8 5.8 17 6.0 1.8 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat MTS PF05175.14 CCF42583.1 - 0.0054 16.3 0.0 0.0058 16.2 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 CCF42583.1 - 0.016 15.9 0.1 0.025 15.3 0.1 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 CCF42583.1 - 0.081 12.8 0.0 0.089 12.6 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 CCF42583.1 - 0.09 12.6 0.1 0.1 12.4 0.1 1.1 1 0 0 1 1 1 0 Methyltransferase domain GSIII_N PF12437.8 CCF42583.1 - 0.096 12.3 0.1 0.11 12.2 0.1 1.1 1 0 0 1 1 1 0 Glutamine synthetase type III N terminal DREV PF05219.12 CCF42583.1 - 0.27 10.3 0.0 0.29 10.2 0.0 1.1 1 0 0 1 1 1 0 DREV methyltransferase CoA_binding_2 PF13380.6 CCF42584.1 - 1.1e-28 100.1 0.0 1.2e-28 99.9 0.0 1.1 1 0 0 1 1 1 1 CoA binding domain SLC12 PF03522.15 CCF42585.1 - 0.81 8.6 26.0 1 8.3 26.0 1.4 1 0 0 1 1 1 0 Solute carrier family 12 Mitofilin PF09731.9 CCF42585.1 - 2.2 7.0 31.9 3 6.6 31.9 1.3 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Hid1 PF12722.7 CCF42585.1 - 5.6 5.0 32.0 7.1 4.6 32.0 1.4 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PCI PF01399.27 CCF42587.1 - 2.3e-10 40.9 0.0 7.3e-10 39.3 0.0 1.9 1 0 0 1 1 1 1 PCI domain RPN7 PF10602.9 CCF42587.1 - 0.0045 16.7 0.1 0.011 15.4 0.1 1.7 1 0 0 1 1 1 1 26S proteasome subunit RPN7 peroxidase PF00141.23 CCF42588.1 - 3.1e-25 89.2 0.1 4.5e-25 88.7 0.1 1.2 1 0 0 1 1 1 1 Peroxidase Peroxidase_ext PF11895.8 CCF42588.1 - 0.00029 20.7 0.0 0.0007 19.5 0.0 1.6 1 0 0 1 1 1 1 Fungal peroxidase extension region PNP_UDP_1 PF01048.20 CCF42589.1 - 3e-10 39.8 0.0 6.9e-10 38.6 0.0 1.7 1 1 0 1 1 1 1 Phosphorylase superfamily NACHT PF05729.12 CCF42589.1 - 1.1e-08 35.2 0.2 3e-08 33.8 0.2 1.7 1 1 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 CCF42589.1 - 2.4e-08 34.5 0.1 8.9e-08 32.7 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 CCF42589.1 - 9.9e-05 22.6 0.0 0.00023 21.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain NB-ARC PF00931.22 CCF42589.1 - 0.00044 19.5 0.0 0.00084 18.6 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain AAA PF00004.29 CCF42589.1 - 0.00064 20.2 0.1 0.0058 17.0 0.1 2.6 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 CCF42589.1 - 0.0011 18.3 0.0 0.41 9.9 0.0 2.9 3 0 0 3 3 3 1 Zeta toxin AAA_18 PF13238.6 CCF42589.1 - 0.01 16.4 0.0 0.028 15.0 0.0 1.8 1 1 0 1 1 1 0 AAA domain APS_kinase PF01583.20 CCF42589.1 - 0.024 14.5 0.0 0.047 13.6 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_33 PF13671.6 CCF42589.1 - 0.066 13.4 0.0 0.23 11.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain Parvo_NS1 PF01057.17 CCF42589.1 - 0.098 11.7 0.0 0.16 11.0 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Cytidylate_kin PF02224.18 CCF42589.1 - 0.14 11.9 0.0 0.3 10.8 0.0 1.6 1 0 0 1 1 1 0 Cytidylate kinase AAA_17 PF13207.6 CCF42589.1 - 0.16 12.4 0.0 0.34 11.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 CCF42589.1 - 0.18 11.5 0.0 0.37 10.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 CCF42589.1 - 0.18 12.2 0.0 0.45 10.9 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_7 PF12775.7 CCF42589.1 - 0.18 11.3 0.0 1.2 8.7 0.0 2.0 2 0 0 2 2 2 0 P-loop containing dynein motor region PfkB PF00294.24 CCF42590.1 - 2.6e-67 227.3 0.1 2.9e-67 227.1 0.1 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 CCF42590.1 - 0.012 15.0 0.0 0.026 13.9 0.0 1.5 1 0 0 1 1 1 0 Phosphomethylpyrimidine kinase DUF2761 PF10959.8 CCF42590.1 - 0.072 13.1 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2761) Fer2_3 PF13085.6 CCF42590.1 - 0.22 11.6 0.1 3.3 7.8 0.1 2.2 1 1 0 2 2 2 0 2Fe-2S iron-sulfur cluster binding domain Sec23_trunk PF04811.15 CCF42594.1 - 4.8e-51 173.7 0.0 1.2e-50 172.3 0.0 1.7 1 1 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 CCF42594.1 - 8e-25 86.6 0.1 1.4e-24 85.8 0.1 1.4 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 CCF42594.1 - 1.5e-17 64.1 0.0 2.8e-17 63.2 0.0 1.5 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 CCF42594.1 - 5e-15 55.3 5.3 1.1e-14 54.2 5.3 1.6 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 CCF42594.1 - 6.6e-05 22.7 0.0 0.00018 21.3 0.0 1.8 1 0 0 1 1 1 1 Gelsolin repeat DEK_C PF08766.11 CCF42594.1 - 0.11 12.5 0.1 0.2 11.6 0.1 1.4 1 0 0 1 1 1 0 DEK C terminal domain Lactamase_B_6 PF16661.5 CCF42595.1 - 3e-65 219.3 0.0 4.7e-65 218.6 0.0 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain CPSF100_C PF13299.6 CCF42595.1 - 9.4e-56 188.6 2.8 9.4e-56 188.6 2.8 2.7 3 0 0 3 3 3 1 Cleavage and polyadenylation factor 2 C-terminal RMMBL PF07521.12 CCF42595.1 - 1.6e-16 60.0 0.0 5.1e-16 58.3 0.0 2.0 2 0 0 2 2 2 1 Zn-dependent metallo-hydrolase RNA specificity domain Beta-Casp PF10996.8 CCF42595.1 - 1.5e-15 57.4 0.0 5.4e-15 55.6 0.0 2.0 2 0 0 2 2 2 1 Beta-Casp domain Lactamase_B_2 PF12706.7 CCF42595.1 - 0.018 14.6 0.0 0.06 12.8 0.0 1.8 1 0 0 1 1 1 0 Beta-lactamase superfamily domain MerR-DNA-bind PF09278.11 CCF42597.1 - 1.7 9.2 10.6 0.49 11.0 0.4 3.4 2 1 1 3 3 3 0 MerR, DNA binding AA_permease PF00324.21 CCF42598.1 - 5e-143 477.2 32.6 6.2e-143 476.9 32.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CCF42598.1 - 2.2e-39 135.5 30.1 2.6e-39 135.2 30.1 1.1 1 0 0 1 1 1 1 Amino acid permease DUF4781 PF16013.5 CCF42598.1 - 0.031 13.1 2.6 0.3 9.8 1.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4781) PknG_TPR PF16918.5 CCF42598.1 - 0.068 11.9 0.1 0.1 11.3 0.1 1.2 1 0 0 1 1 1 0 Protein kinase G tetratricopeptide repeat MFS_1 PF07690.16 CCF42600.1 - 2.5e-24 85.9 20.7 2.9e-24 85.7 20.7 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF42600.1 - 3.2e-08 32.9 11.8 4.1e-08 32.5 11.8 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter TRI12 PF06609.13 CCF42600.1 - 1.9e-05 23.3 6.8 2.3e-05 23.1 6.8 1.0 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.20 CCF42600.1 - 0.0053 15.1 1.6 0.0053 15.1 1.6 1.5 2 0 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family MFS_5 PF05631.14 CCF42600.1 - 0.0096 14.9 0.5 0.012 14.6 0.5 1.2 1 0 0 1 1 1 1 Sugar-tranasporters, 12 TM PP-binding PF00550.25 CCF42601.1 - 2.1e-13 50.4 0.1 4.2e-13 49.5 0.1 1.5 1 0 0 1 1 1 1 Phosphopantetheine attachment site PS-DH PF14765.6 CCF42601.1 - 2e-11 43.7 3.0 2.4e-05 23.7 0.4 2.5 1 1 1 2 2 2 2 Polyketide synthase dehydratase Choline_transpo PF04515.12 CCF42602.1 - 5.2e-82 275.7 22.5 5.2e-82 275.7 22.5 2.2 2 1 0 2 2 2 1 Plasma-membrane choline transporter AMP-binding PF00501.28 CCF42605.1 - 5.9e-43 147.0 0.0 8e-43 146.6 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme ACAS_N PF16177.5 CCF42605.1 - 7.8e-11 41.7 1.4 1.4e-10 40.9 0.1 2.1 2 0 0 2 2 2 1 Acetyl-coenzyme A synthetase N-terminus AMP-binding_C PF13193.6 CCF42605.1 - 1.2e-05 26.2 0.3 3.3e-05 24.8 0.3 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain CoA_transf_3 PF02515.17 CCF42606.1 - 5.3e-39 134.4 0.2 2.6e-38 132.1 0.1 1.9 2 0 0 2 2 2 1 CoA-transferase family III Na_H_Exchanger PF00999.21 CCF42607.1 - 1.7e-30 106.1 34.5 1.2e-24 86.9 23.1 3.1 3 0 0 3 3 3 3 Sodium/hydrogen exchanger family Rep-A_N PF04057.12 CCF42608.1 - 0.02 14.9 0.0 0.052 13.6 0.0 1.6 2 0 0 2 2 2 0 Replication factor-A protein 1, N-terminal domain REPA_OB_2 PF16900.5 CCF42608.1 - 0.029 14.3 0.0 0.066 13.1 0.0 1.5 1 0 0 1 1 1 0 Replication protein A OB domain MFS_1 PF07690.16 CCF42611.1 - 1.2e-49 169.1 39.2 1.5e-49 168.8 39.2 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF42611.1 - 3e-13 49.5 12.7 3e-13 49.5 12.7 2.8 2 1 1 3 3 3 1 Sugar (and other) transporter MFS_4 PF06779.14 CCF42611.1 - 4.5e-05 22.9 11.5 4.5e-05 22.9 11.5 1.9 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB MFS_3 PF05977.13 CCF42611.1 - 0.15 10.4 8.8 0.24 9.7 8.8 1.3 1 0 0 1 1 1 0 Transmembrane secretion effector DDE_1 PF03184.19 CCF42612.1 - 6.5e-12 45.5 0.0 1.6e-11 44.2 0.0 1.7 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 CCF42612.1 - 1.4e-10 41.1 0.1 2.8e-10 40.1 0.1 1.6 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 CCF42612.1 - 2.4e-08 33.5 0.1 4.3e-08 32.8 0.1 1.4 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_28 PF13518.6 CCF42612.1 - 0.0026 17.9 0.8 0.0082 16.2 0.2 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.6 CCF42612.1 - 0.0067 16.2 0.1 0.02 14.7 0.1 1.7 1 0 0 1 1 1 1 Homeodomain-like domain HTH_7 PF02796.15 CCF42612.1 - 0.0073 16.4 0.6 0.014 15.5 0.6 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_Tnp_IS630 PF01710.16 CCF42612.1 - 0.026 14.6 0.0 0.048 13.7 0.0 1.4 1 0 0 1 1 1 0 Transposase HTH_Tnp_ISL3 PF13542.6 CCF42612.1 - 0.06 12.8 0.0 0.12 11.8 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 HTH_8 PF02954.19 CCF42612.1 - 0.067 13.0 0.2 0.19 11.5 0.2 1.8 1 1 0 1 1 1 0 Bacterial regulatory protein, Fis family Methyltransf_2 PF00891.18 CCF42613.1 - 1.9e-23 82.9 0.0 3.1e-23 82.2 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_25 PF13649.6 CCF42613.1 - 0.055 14.2 0.1 0.24 12.1 0.1 2.1 2 0 0 2 2 2 0 Methyltransferase domain DUF4743 PF15916.5 CCF42613.1 - 0.095 12.7 0.0 1.1 9.2 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4743) DUF676 PF05057.14 CCF42615.1 - 0.00059 19.4 0.0 0.00096 18.7 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_6 PF12697.7 CCF42615.1 - 0.001 19.7 0.0 0.0018 18.9 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.13 CCF42615.1 - 0.0049 16.6 0.0 0.0077 16.0 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Hydrolase_4 PF12146.8 CCF42615.1 - 0.0061 15.9 0.0 0.0084 15.4 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Cutinase PF01083.22 CCF42615.1 - 0.011 15.7 0.0 0.015 15.3 0.0 1.2 1 0 0 1 1 1 0 Cutinase NAD_binding_8 PF13450.6 CCF42616.1 - 3.8e-09 36.6 0.2 1.2e-08 35.1 0.2 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 CCF42616.1 - 2.6e-07 30.3 0.3 1.9e-05 24.2 0.0 2.1 1 1 0 2 2 2 1 Flavin containing amine oxidoreductase FAD_oxidored PF12831.7 CCF42616.1 - 4.2e-07 29.7 2.7 5e-07 29.4 1.5 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CCF42616.1 - 4.8e-06 25.9 3.0 7.2e-06 25.3 3.0 1.2 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 CCF42616.1 - 2.7e-05 23.1 2.2 4.3e-05 22.4 2.2 1.2 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_2 PF07992.14 CCF42616.1 - 8.9e-05 21.8 0.5 0.0002 20.7 0.5 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCF42616.1 - 0.0002 21.1 2.0 0.0011 18.6 1.9 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 CCF42616.1 - 0.00022 20.6 0.1 0.0003 20.2 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 CCF42616.1 - 0.0005 19.4 0.3 0.00076 18.8 0.3 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CCF42616.1 - 0.0005 19.4 0.6 0.00088 18.6 0.6 1.3 1 0 0 1 1 1 1 Thi4 family GIDA PF01134.22 CCF42616.1 - 0.0027 16.9 1.2 0.004 16.3 1.2 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox PF00070.27 CCF42616.1 - 0.0054 17.3 0.9 0.013 16.1 0.2 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 CCF42616.1 - 0.025 13.9 1.5 0.051 12.9 1.5 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_7 PF13241.6 CCF42616.1 - 0.08 13.4 0.0 0.15 12.5 0.0 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding Trp_halogenase PF04820.14 CCF42616.1 - 0.24 10.2 1.0 0.35 9.7 1.0 1.2 1 0 0 1 1 1 0 Tryptophan halogenase Septin PF00735.18 CCF42617.1 - 1.4e-106 355.9 0.0 3e-106 354.8 0.0 1.5 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 CCF42617.1 - 8.2e-05 22.7 0.0 0.0002 21.4 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 CCF42617.1 - 0.0083 16.2 4.9 1.6 8.8 0.0 3.0 2 1 1 3 3 3 2 Dynamin family IIGP PF05049.13 CCF42617.1 - 0.019 14.0 0.0 0.034 13.2 0.0 1.4 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) EB1 PF03271.17 CCF42617.1 - 0.037 14.3 1.2 1.8 8.9 1.3 2.6 2 0 0 2 2 2 0 EB1-like C-terminal motif GTP_EFTU PF00009.27 CCF42617.1 - 0.093 12.3 0.0 0.34 10.4 0.0 1.9 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_23 PF13476.6 CCF42617.1 - 0.15 12.6 5.1 17 5.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 CCF42617.1 - 0.17 11.8 4.5 0.081 12.8 0.7 2.3 2 1 0 2 2 2 0 RsgA GTPase AAA_22 PF13401.6 CCF42617.1 - 0.3 11.3 1.7 0.32 11.3 0.2 2.0 2 1 0 2 2 2 0 AAA domain Zn_clus PF00172.18 CCF42620.1 - 1.9e-09 37.5 10.9 2.9e-09 36.9 10.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 CCF42620.1 - 9.4e-06 24.7 0.0 2.5e-05 23.3 0.0 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain MFS_1 PF07690.16 CCF42621.1 - 7.7e-30 104.0 37.0 7.7e-30 104.0 37.0 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF4234 PF14018.6 CCF42621.1 - 1.1 9.5 4.1 14 5.9 0.0 4.0 3 1 1 4 4 4 0 Domain of unknown function (DUF4234) Peptidase_M19 PF01244.21 CCF42622.1 - 3.3e-102 341.9 0.0 3.8e-102 341.7 0.0 1.0 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) EF-hand_1 PF00036.32 CCF42625.1 - 8.6e-26 87.5 3.5 5.3e-06 25.6 0.0 5.4 5 0 0 5 5 5 5 EF hand EF-hand_7 PF13499.6 CCF42625.1 - 7.1e-22 77.6 1.9 3.2e-09 37.1 0.0 3.9 3 1 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 CCF42625.1 - 5.8e-21 72.6 3.1 0.0022 17.8 0.6 5.3 5 0 0 5 5 5 5 EF-hand domain EF-hand_8 PF13833.6 CCF42625.1 - 2.6e-19 68.8 5.2 3.4e-09 36.4 0.0 4.9 3 2 2 5 5 5 4 EF-hand domain pair EF-hand_5 PF13202.6 CCF42625.1 - 1.2e-16 59.3 1.2 0.0008 18.8 0.0 4.5 4 0 0 4 4 4 4 EF hand Sugar_tr PF00083.24 CCF42626.1 - 5.7e-62 210.0 33.6 7.1e-62 209.7 33.6 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF42626.1 - 1.7e-22 79.8 31.2 2.2e-22 79.5 30.7 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Ribosomal_L12 PF00542.19 CCF42626.1 - 0.14 12.5 0.2 0.27 11.6 0.2 1.4 1 0 0 1 1 1 0 Ribosomal protein L7/L12 C-terminal domain Vps8 PF12816.7 CCF42627.1 - 2.3e-75 252.5 0.2 4.7e-75 251.5 0.1 1.6 2 0 0 2 2 2 1 Golgi CORVET complex core vacuolar protein 8 Clathrin PF00637.20 CCF42627.1 - 3.4e-06 27.0 0.0 0.028 14.3 0.0 3.1 4 0 0 4 4 4 2 Region in Clathrin and VPS zf-RING_5 PF14634.6 CCF42627.1 - 0.0042 17.0 0.0 0.0042 17.0 0.0 1.6 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 CCF42627.1 - 0.021 14.8 0.2 0.057 13.4 0.2 1.8 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_11 PF17123.5 CCF42627.1 - 0.031 14.0 0.1 0.072 12.8 0.1 1.6 1 0 0 1 1 1 0 RING-like zinc finger zf-C3H2C3 PF17122.5 CCF42627.1 - 0.064 13.3 0.1 0.16 12.1 0.1 1.6 1 0 0 1 1 1 0 Zinc-finger zf-rbx1 PF12678.7 CCF42627.1 - 0.079 13.3 0.0 0.17 12.2 0.0 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_2 PF13639.6 CCF42627.1 - 0.093 13.1 0.1 0.093 13.1 0.1 1.8 2 0 0 2 2 2 0 Ring finger domain zf-C3HC4_2 PF13923.6 CCF42627.1 - 0.11 12.3 0.2 1.3 9.0 0.0 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) HEAT PF02985.22 CCF42628.1 - 1.1e-14 53.3 13.5 0.0032 17.6 0.0 9.8 11 0 0 11 11 9 2 HEAT repeat HEAT_EZ PF13513.6 CCF42628.1 - 3.9e-12 46.4 7.4 1.5e-07 31.8 0.0 7.2 8 1 1 9 9 8 1 HEAT-like repeat HEAT_2 PF13646.6 CCF42628.1 - 3.4e-07 30.6 11.1 0.0019 18.5 0.2 6.5 3 2 4 7 7 7 3 HEAT repeats IBN_N PF03810.19 CCF42628.1 - 6.6e-07 29.2 0.3 0.00078 19.3 0.0 4.2 3 0 0 3 3 3 1 Importin-beta N-terminal domain MMS19_C PF12460.8 CCF42628.1 - 3.9e-06 26.2 3.8 6.2e-06 25.6 0.8 2.6 2 2 0 2 2 2 1 RNAPII transcription regulator C-terminal CLASP_N PF12348.8 CCF42628.1 - 1.5e-05 24.7 1.5 2.3 7.7 0.2 4.7 3 1 2 5 5 5 3 CLASP N terminal DRIM PF07539.12 CCF42628.1 - 0.0003 19.3 0.2 1.5 7.0 0.0 4.1 2 1 0 3 3 3 2 Down-regulated in metastasis Arm PF00514.23 CCF42628.1 - 0.0035 17.3 0.9 36 4.6 0.0 5.7 6 0 0 6 6 6 0 Armadillo/beta-catenin-like repeat DUF3385 PF11865.8 CCF42628.1 - 0.0056 16.6 1.9 5.2 7.0 0.3 4.6 4 2 0 4 4 4 1 Domain of unknown function (DUF3385) DUF3347 PF11827.8 CCF42628.1 - 0.051 13.8 0.8 0.098 12.8 0.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3347) HEAT_PBS PF03130.16 CCF42628.1 - 0.084 13.6 0.3 51 5.0 0.0 4.9 4 0 0 4 4 3 0 PBS lyase HEAT-like repeat Sec7_N PF12783.7 CCF42628.1 - 0.11 12.3 0.1 1 9.3 0.0 2.7 1 1 1 2 2 2 0 Guanine nucleotide exchange factor in Golgi transport N-terminal Sugar_tr PF00083.24 CCF42629.1 - 4.3e-98 329.1 20.7 5e-98 328.9 20.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF42629.1 - 1.9e-22 79.7 35.8 2.3e-19 69.6 21.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 CCF42629.1 - 0.00044 18.8 4.2 0.00076 18.0 0.6 2.1 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) PAM2 PF07145.15 CCF42630.1 - 0.0019 17.8 0.1 0.012 15.3 0.0 2.3 2 0 0 2 2 2 1 Ataxin-2 C-terminal region SOG2 PF10428.9 CCF42630.1 - 8 5.5 8.9 8.6 5.4 8.9 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein MFS_1 PF07690.16 CCF42631.1 - 1.6e-12 47.1 41.4 1.6e-12 47.1 41.4 2.7 1 1 1 2 2 2 1 Major Facilitator Superfamily Fungal_trans PF04082.18 CCF42633.1 - 9.4e-12 44.5 0.0 1.5e-11 43.9 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF42633.1 - 8e-06 25.9 13.1 1.3e-05 25.3 13.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_hydro_7 PF00840.20 CCF42634.1 - 2.8e-195 649.1 12.2 3.3e-195 648.9 12.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 7 CBM_1 PF00734.18 CCF42634.1 - 9.4e-07 28.7 2.9 9.4e-07 28.7 2.9 3.7 3 1 0 3 3 3 1 Fungal cellulose binding domain ADH_N PF08240.12 CCF42636.1 - 5.2e-21 74.6 1.2 6.3e-21 74.3 0.3 1.6 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCF42636.1 - 4.1e-12 46.2 3.7 6.8e-12 45.5 3.7 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 CCF42636.1 - 0.062 12.6 3.1 0.094 12.0 1.4 2.0 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain adh_short PF00106.25 CCF42636.1 - 0.27 10.7 2.7 0.33 10.4 0.9 1.9 2 0 0 2 2 2 0 short chain dehydrogenase NAD_binding_5 PF07994.12 CCF42639.1 - 6.3e-142 472.7 0.0 8.6e-142 472.3 0.0 1.2 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.17 CCF42639.1 - 2.2e-45 153.4 0.6 3.6e-45 152.7 0.6 1.4 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase PP-binding PF00550.25 CCF42641.1 - 1.9e-05 24.9 0.2 2.1e-05 24.8 0.2 1.1 1 0 0 1 1 1 1 Phosphopantetheine attachment site zf-C2H2_assoc2 PF16624.5 CCF42641.1 - 0.22 12.5 0.0 0.37 11.8 0.0 1.4 2 0 0 2 2 2 0 Unstructured region upstream of a zinc-finger MnmE_helical PF12631.7 CCF42643.1 - 7.8e-34 117.6 0.2 9.2e-34 117.4 0.2 1.0 1 0 0 1 1 1 1 MnmE helical domain TrmE_N PF10396.9 CCF42643.1 - 2.2e-21 76.3 0.0 4.7e-21 75.2 0.0 1.6 1 0 0 1 1 1 1 GTP-binding protein TrmE N-terminus MMR_HSR1 PF01926.23 CCF42643.1 - 3.7e-18 65.7 0.0 6.9e-18 64.8 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CCF42643.1 - 3e-05 23.6 0.0 5.6e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 CCF42643.1 - 0.0002 21.5 0.0 0.00031 20.8 0.0 1.4 1 0 0 1 1 1 1 Dynamin family RsgA_GTPase PF03193.16 CCF42643.1 - 0.0029 17.6 0.0 0.056 13.4 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_24 PF13479.6 CCF42643.1 - 0.02 14.6 0.0 0.036 13.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CCF42643.1 - 0.037 14.5 0.0 0.091 13.3 0.0 1.7 1 0 0 1 1 1 0 ABC transporter Glyco_hydro_3_C PF01915.22 CCF42643.1 - 0.14 12.1 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 3 C-terminal domain Ribosomal_L28e PF01778.17 CCF42644.1 - 3.5e-38 130.9 1.2 4.3e-38 130.6 1.2 1.1 1 0 0 1 1 1 1 Ribosomal L28e protein family CxC6 PF18721.1 CCF42644.1 - 0.066 13.5 0.3 0.51 10.6 0.3 2.0 2 0 0 2 2 2 0 CxC6 like cysteine cluster associated with KDZ transposases ketoacyl-synt PF00109.26 CCF42645.1 - 9.2e-75 251.5 0.1 2.1e-74 250.3 0.0 1.7 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 CCF42645.1 - 2.2e-49 168.7 0.1 4.4e-49 167.7 0.1 1.4 1 0 0 1 1 1 1 Acyl transferase domain PS-DH PF14765.6 CCF42645.1 - 1.4e-45 155.9 0.0 2.2e-45 155.2 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Ketoacyl-synt_C PF02801.22 CCF42645.1 - 6.6e-30 103.6 0.1 1.6e-29 102.3 0.1 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KR PF08659.10 CCF42645.1 - 3.2e-23 82.6 0.2 1.1e-17 64.6 0.0 2.6 1 1 1 2 2 2 2 KR domain KAsynt_C_assoc PF16197.5 CCF42645.1 - 4.1e-08 33.7 0.0 1.1e-07 32.3 0.0 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension adh_short PF00106.25 CCF42645.1 - 0.00011 21.7 0.0 0.00027 20.5 0.0 1.6 1 0 0 1 1 1 1 short chain dehydrogenase Thiolase_N PF00108.23 CCF42645.1 - 0.00039 19.9 0.0 0.00077 18.9 0.0 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain SAT PF16073.5 CCF42645.1 - 0.00049 19.9 0.3 0.0095 15.7 0.3 2.4 1 1 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Methyltransf_12 PF08242.12 CCF42645.1 - 0.00083 20.1 0.0 0.0022 18.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain adh_short_C2 PF13561.6 CCF42645.1 - 0.012 15.1 0.0 0.06 12.9 0.0 2.1 2 0 0 2 2 2 0 Enoyl-(Acyl carrier protein) reductase PP-binding PF00550.25 CCF42645.1 - 0.02 15.2 0.0 0.07 13.5 0.0 2.0 1 0 0 1 1 1 0 Phosphopantetheine attachment site Methyltransf_31 PF13847.6 CCF42645.1 - 0.035 13.9 0.0 0.08 12.7 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain CBM_1 PF00734.18 CCF42646.1 - 1.8e-10 40.6 15.9 1.8e-10 40.6 15.9 3.0 4 0 0 4 4 4 1 Fungal cellulose binding domain Lipase_GDSL_2 PF13472.6 CCF42646.1 - 1.4e-08 35.3 0.4 2.6e-08 34.5 0.4 1.5 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 CCF42646.1 - 0.00077 19.5 0.0 0.0011 19.0 0.0 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Sporozoite_P67 PF05642.11 CCF42646.1 - 1.2 7.2 12.7 1.6 6.7 12.7 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen MGC-24 PF05283.11 CCF42646.1 - 5.5 7.4 10.1 13 6.2 10.1 1.6 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin DUF3218 PF11508.8 CCF42647.1 - 0.18 11.3 0.1 0.2 11.1 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3218) AMP-binding PF00501.28 CCF42648.1 - 3.3e-42 144.6 0.0 4.1e-42 144.3 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme p450 PF00067.22 CCF42649.1 - 2.1e-49 168.5 0.0 7.3e-49 166.8 0.0 1.7 1 1 0 1 1 1 1 Cytochrome P450 AcetylCoA_hydro PF02550.15 CCF42649.1 - 0.038 14.0 0.0 0.064 13.2 0.0 1.3 1 0 0 1 1 1 0 Acetyl-CoA hydrolase/transferase N-terminal domain Polyketide_cyc2 PF10604.9 CCF42650.1 - 5.1e-05 23.6 0.0 5.8e-05 23.4 0.0 1.4 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Sugar_tr PF00083.24 CCF42651.1 - 9.3e-30 103.9 24.6 5.7e-28 98.0 24.6 2.3 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF42651.1 - 5.1e-29 101.3 48.6 5.3e-28 98.0 26.1 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily AMP-binding PF00501.28 CCF42652.1 - 2.4e-27 95.6 0.0 3.5e-27 95.1 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.25 CCF42652.1 - 0.0023 18.2 0.1 0.0055 17.0 0.1 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site JAB PF01398.21 CCF42653.1 - 0.001 19.0 0.6 0.017 15.1 0.2 2.3 1 1 1 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease CorA PF01544.18 CCF42654.1 - 1.1e-27 97.2 0.3 1.2e-27 97.0 0.3 1.0 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein Peptidase_M14 PF00246.24 CCF42655.1 - 1.6e-71 241.5 0.0 2.3e-71 241.0 0.0 1.2 1 0 0 1 1 1 1 Zinc carboxypeptidase DUF4061 PF13270.6 CCF42656.1 - 0.18 12.1 0.1 0.26 11.6 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4061) Fungal_trans PF04082.18 CCF42657.1 - 2.7e-34 118.4 1.7 4e-34 117.9 0.3 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain AMP-binding PF00501.28 CCF42658.1 - 2.5e-40 138.4 0.0 3.8e-40 137.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme ACAS_N PF16177.5 CCF42658.1 - 0.00017 21.5 0.1 0.0004 20.2 0.1 1.7 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus AMP-binding_C PF13193.6 CCF42658.1 - 0.061 14.3 0.0 0.13 13.3 0.0 1.5 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain ANAPC3 PF12895.7 CCF42659.1 - 3.6e-25 88.0 21.2 1.4e-22 79.7 0.5 5.7 4 2 2 7 7 7 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 CCF42659.1 - 8.6e-24 82.3 11.6 3.4e-05 23.5 0.4 9.6 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_19 PF14559.6 CCF42659.1 - 8.3e-22 77.5 16.5 0.00094 19.7 0.1 7.7 6 2 1 8 8 8 6 Tetratricopeptide repeat TPR_2 PF07719.17 CCF42659.1 - 5.9e-21 72.8 22.3 0.0014 18.6 0.2 10.4 12 0 0 12 12 11 5 Tetratricopeptide repeat TPR_8 PF13181.6 CCF42659.1 - 7e-18 63.3 5.0 0.0038 17.3 0.2 8.7 9 0 0 9 9 8 4 Tetratricopeptide repeat TPR_12 PF13424.6 CCF42659.1 - 8.2e-16 58.1 17.9 0.00011 22.4 0.0 8.9 6 1 3 9 9 9 5 Tetratricopeptide repeat TPR_14 PF13428.6 CCF42659.1 - 1.6e-13 50.2 16.3 0.2 12.6 0.0 9.6 7 4 2 9 9 9 4 Tetratricopeptide repeat TPR_16 PF13432.6 CCF42659.1 - 3.1e-10 40.5 14.7 0.022 15.4 0.4 8.4 6 4 2 9 9 9 3 Tetratricopeptide repeat TPR_10 PF13374.6 CCF42659.1 - 1.6e-07 30.9 12.1 0.1 12.5 0.0 8.1 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_7 PF13176.6 CCF42659.1 - 1.7e-07 30.8 16.0 2.6 8.3 0.0 8.8 10 0 0 10 10 9 1 Tetratricopeptide repeat TPR_11 PF13414.6 CCF42659.1 - 3.4e-06 26.6 6.1 0.56 9.9 0.0 6.2 7 0 0 7 7 6 2 TPR repeat TPR_6 PF13174.6 CCF42659.1 - 9.6e-06 25.9 9.5 1.1 10.1 0.1 7.5 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_15 PF13429.6 CCF42659.1 - 9.7e-05 21.7 4.8 0.61 9.3 0.0 5.2 4 2 2 7 7 7 2 Tetratricopeptide repeat TPR_9 PF13371.6 CCF42659.1 - 0.00016 21.8 3.2 2.9 8.1 0.3 4.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_4 PF07721.14 CCF42659.1 - 0.00091 19.6 1.1 2.3 9.1 0.0 5.5 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_17 PF13431.6 CCF42659.1 - 0.028 14.8 3.7 1e+02 3.6 0.0 6.6 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_21 PF09976.9 CCF42659.1 - 0.077 12.7 4.4 1.8 8.2 0.5 4.0 4 1 0 4 4 4 0 Tetratricopeptide repeat-like domain Hexapep PF00132.24 CCF42660.1 - 7.8e-06 25.4 2.9 0.0043 16.7 0.3 3.5 1 1 3 4 4 4 4 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 CCF42660.1 - 0.00023 21.6 0.0 0.00044 20.6 0.0 1.5 1 0 0 1 1 1 1 MobA-like NTP transferase domain Fucokinase PF07959.12 CCF42660.1 - 0.0005 19.1 0.2 0.00069 18.7 0.2 1.1 1 0 0 1 1 1 1 L-fucokinase DUF4954 PF16314.5 CCF42660.1 - 0.00051 18.3 0.8 0.00074 17.8 0.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) NTP_transferase PF00483.23 CCF42660.1 - 0.056 13.0 0.0 0.13 11.8 0.0 1.5 2 0 0 2 2 2 0 Nucleotidyl transferase Hexapep_2 PF14602.6 CCF42660.1 - 0.2 11.4 5.7 0.21 11.4 0.2 3.2 3 1 0 3 3 3 0 Hexapeptide repeat of succinyl-transferase TruB_C PF09142.11 CCF42661.1 - 0.66 9.8 5.9 0.15 11.8 2.3 1.8 2 0 0 2 2 2 0 tRNA Pseudouridine synthase II, C terminal Aldolase_II PF00596.21 CCF42663.1 - 4.5e-28 98.4 0.3 6.1e-28 98.0 0.3 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Ketoacyl-synt_C PF02801.22 CCF42663.1 - 0.061 13.3 0.1 0.1 12.6 0.1 1.3 1 0 0 1 1 1 0 Beta-ketoacyl synthase, C-terminal domain Glyco_hydro_cc PF11790.8 CCF42664.1 - 3.8e-11 43.0 0.0 4.4e-11 42.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core Ras PF00071.22 CCF42665.1 - 6.8e-60 201.3 0.3 7.9e-60 201.1 0.3 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCF42665.1 - 1.8e-20 73.4 0.0 2.7e-20 72.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCF42665.1 - 2.9e-08 33.4 0.0 3.2e-08 33.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 CCF42665.1 - 6.2e-06 25.9 0.1 3.4e-05 23.5 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 CCF42665.1 - 5.7e-05 23.1 0.7 0.21 11.5 0.0 2.4 1 1 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 CCF42665.1 - 0.0017 18.4 0.0 0.0026 17.8 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase MMR_HSR1_Xtn PF16897.5 CCF42665.1 - 0.0021 18.1 0.0 0.004 17.1 0.0 1.5 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain FeoB_N PF02421.18 CCF42665.1 - 0.0024 17.4 0.0 0.0045 16.5 0.0 1.5 1 1 0 1 1 1 1 Ferrous iron transport protein B ATP_bind_1 PF03029.17 CCF42665.1 - 0.064 13.0 2.0 0.58 9.9 0.1 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein VGCC_beta4Aa_N PF12052.8 CCF42665.1 - 0.98 9.6 2.8 0.67 10.1 0.5 1.9 2 0 0 2 2 2 0 Voltage gated calcium channel subunit beta domain 4Aa N terminal DUF3500 PF12006.8 CCF42666.1 - 1.1e-110 369.8 0.0 1.3e-110 369.5 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3500) Rubis-subs-bind PF09273.11 CCF42668.1 - 5.1e-13 49.8 2.6 1.1e-12 48.8 2.6 1.7 1 1 0 1 1 1 1 Rubisco LSMT substrate-binding SET PF00856.28 CCF42668.1 - 1.6e-08 35.2 0.0 4.2e-08 33.8 0.0 1.7 2 0 0 2 2 2 1 SET domain ALIX_LYPXL_bnd PF13949.6 CCF42668.1 - 0.0083 15.5 0.3 0.013 14.8 0.3 1.3 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV zf-Nse PF11789.8 CCF42670.1 - 3.6e-18 65.1 0.3 1e-17 63.7 0.2 1.9 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.6 CCF42670.1 - 0.00063 19.7 0.1 0.0012 18.8 0.1 1.5 1 0 0 1 1 1 1 RING-type zinc-finger ABC_tran_CTD PF16326.5 CCF42670.1 - 0.01 16.1 5.3 1.2 9.4 0.0 2.8 3 0 0 3 3 3 0 ABC transporter C-terminal domain DUF2312 PF10073.9 CCF42670.1 - 0.017 14.7 1.2 7.4 6.3 0.1 2.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2312) Fib_alpha PF08702.10 CCF42670.1 - 0.048 13.9 2.1 2.7 8.1 0.0 2.9 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family zf-C3HC4_2 PF13923.6 CCF42670.1 - 0.15 12.0 0.1 0.28 11.1 0.1 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 CCF42670.1 - 0.15 12.2 0.1 0.32 11.2 0.1 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Rootletin PF15035.6 CCF42670.1 - 0.27 11.3 8.4 0.063 13.3 1.4 2.6 3 0 0 3 3 3 0 Ciliary rootlet component, centrosome cohesion DUF1192 PF06698.11 CCF42670.1 - 0.31 11.1 6.7 2.7 8.1 0.2 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) HsbA PF12296.8 CCF42670.1 - 0.34 11.4 2.2 11 6.4 0.2 2.5 2 1 0 2 2 2 0 Hydrophobic surface binding protein A Baculo_PEP_C PF04513.12 CCF42670.1 - 0.47 10.5 1.7 41 4.2 0.1 3.4 4 0 0 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus zf-MIZ PF02891.20 CCF42670.1 - 0.72 9.7 2.0 0.81 9.5 0.6 1.8 2 0 0 2 2 2 0 MIZ/SP-RING zinc finger Zn_clus PF00172.18 CCF42671.1 - 0.41 10.8 6.1 0.9 9.7 6.1 1.6 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain SNARE PF05739.19 CCF42672.1 - 7.1e-09 35.5 2.1 1.4e-08 34.6 2.1 1.5 1 0 0 1 1 1 1 SNARE domain Fusion_gly PF00523.18 CCF42672.1 - 0.0087 14.4 0.3 0.015 13.6 0.3 1.3 1 0 0 1 1 1 1 Fusion glycoprotein F0 GOLGA2L5 PF15070.6 CCF42672.1 - 0.065 11.9 2.6 0.099 11.3 0.2 1.9 2 0 0 2 2 2 0 Putative golgin subfamily A member 2-like protein 5 Sec23_helical PF04815.15 CCF42672.1 - 0.1 12.4 0.0 0.21 11.4 0.0 1.5 1 0 0 1 1 1 0 Sec23/Sec24 helical domain WD40 PF00400.32 CCF42673.1 - 1.9e-06 28.5 1.7 0.0006 20.6 0.0 3.9 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF42673.1 - 7.7e-05 22.9 0.0 0.014 15.6 0.0 3.4 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain PPTA PF01239.22 CCF42674.1 - 2.2e-40 135.3 10.3 9.1e-08 31.6 0.0 5.3 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat DUF3950 PF13132.6 CCF42674.1 - 0.12 12.2 0.4 7 6.5 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3950) Aminotran_1_2 PF00155.21 CCF42676.1 - 1.2e-21 77.3 0.0 1.2e-19 70.7 0.0 2.6 2 1 1 3 3 3 2 Aminotransferase class I and II Aminotran_5 PF00266.19 CCF42676.1 - 0.042 12.8 0.0 0.051 12.5 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class-V Fungal_trans PF04082.18 CCF42677.1 - 0.012 14.6 0.0 0.019 14.0 0.0 1.2 1 0 0 1 1 1 0 Fungal specific transcription factor domain Beta-lactamase PF00144.24 CCF42678.1 - 3.5e-40 138.2 0.0 5.2e-39 134.4 0.0 2.0 1 1 0 1 1 1 1 Beta-lactamase Lyase_8 PF02278.18 CCF42678.1 - 0.0099 15.4 0.0 0.018 14.5 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide lyase family 8, super-sandwich domain FMO-like PF00743.19 CCF42679.1 - 2.5e-15 55.9 0.3 4.8e-13 48.4 0.0 2.3 2 1 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 CCF42679.1 - 8.6e-10 38.3 0.0 7.7e-05 22.1 0.0 2.7 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCF42679.1 - 4.7e-08 32.6 0.0 4.3e-07 29.5 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CCF42679.1 - 1.1e-07 31.4 0.0 4.6e-07 29.3 0.0 1.9 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 CCF42679.1 - 0.00099 19.3 0.0 0.18 12.0 0.0 3.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain PTR2 PF00854.21 CCF42681.1 - 4.9e-51 173.8 8.4 1.1e-50 172.7 8.4 1.5 1 1 0 1 1 1 1 POT family PXA PF02194.15 CCF42682.1 - 1.8e-36 125.8 0.1 3.5e-36 124.9 0.1 1.5 1 0 0 1 1 1 1 PXA domain FliJ PF02050.16 CCF42682.1 - 0.0097 16.1 2.6 0.02 15.1 2.6 1.4 1 0 0 1 1 1 1 Flagellar FliJ protein DUF5428 PF17493.2 CCF42683.1 - 0.0075 16.7 0.4 0.0091 16.4 0.4 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5428) Zn_clus PF00172.18 CCF42684.1 - 0.012 15.7 2.4 0.019 15.0 2.4 1.2 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain ABC2_membrane PF01061.24 CCF42686.1 - 5.2e-71 238.4 46.6 4.6e-50 170.0 19.9 2.9 3 0 0 3 3 3 2 ABC-2 type transporter PDR_CDR PF06422.12 CCF42686.1 - 1.4e-34 117.9 3.7 9.3e-32 108.8 0.0 3.6 3 0 0 3 3 3 2 CDR ABC transporter ABC_tran PF00005.27 CCF42686.1 - 1e-16 61.7 0.0 1.7e-16 61.0 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_16 PF13191.6 CCF42686.1 - 7.3e-05 23.2 0.1 0.00015 22.2 0.1 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.6 CCF42686.1 - 0.00013 21.9 0.2 0.52 10.1 0.0 2.6 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_25 PF13481.6 CCF42686.1 - 0.00015 21.4 0.0 0.00024 20.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 CCF42686.1 - 0.00031 20.7 0.0 0.00058 19.8 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase ABC2_membrane_3 PF12698.7 CCF42686.1 - 0.00033 19.9 8.0 0.00033 19.9 8.0 3.3 2 2 0 2 2 2 1 ABC-2 family transporter protein AAA_29 PF13555.6 CCF42686.1 - 0.0072 16.0 0.1 0.02 14.6 0.1 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_33 PF13671.6 CCF42686.1 - 0.0078 16.4 0.0 0.018 15.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CCF42686.1 - 0.0096 16.5 0.2 0.022 15.3 0.0 1.7 2 0 0 2 2 1 1 AAA domain cobW PF02492.19 CCF42686.1 - 0.03 13.9 0.2 0.061 12.9 0.2 1.5 1 1 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain SMC_N PF02463.19 CCF42686.1 - 0.042 13.3 0.0 1.5 8.2 0.0 2.3 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CCF42686.1 - 0.046 14.2 0.0 0.1 13.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 CCF42686.1 - 0.097 12.9 0.0 0.39 11.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 CCF42686.1 - 0.12 12.1 0.1 0.21 11.3 0.1 1.4 1 0 0 1 1 1 0 AAA domain Sel1 PF08238.12 CCF42687.1 - 1e-11 45.1 6.8 0.0008 20.0 0.1 5.2 4 1 0 4 4 4 3 Sel1 repeat WD40 PF00400.32 CCF42688.1 - 4.9e-06 27.2 6.4 0.0074 17.1 0.0 4.0 4 1 0 4 4 4 2 WD domain, G-beta repeat Bcl-2_3 PF15286.6 CCF42689.1 - 0.0052 17.4 0.0 0.01 16.5 0.0 1.4 1 0 0 1 1 1 1 Apoptosis regulator M11, B cell 2 leukaemia/lymphoma like Tmemb_185A PF10269.9 CCF42689.1 - 0.022 14.5 0.3 1.5 8.5 0.0 2.1 1 1 1 2 2 2 0 Transmembrane Fragile-X-F protein MARVEL PF01284.23 CCF42689.1 - 0.046 13.8 3.4 0.068 13.2 3.4 1.2 1 0 0 1 1 1 0 Membrane-associating domain TPR_19 PF14559.6 CCF42691.1 - 0.0094 16.4 0.0 0.015 15.8 0.0 1.3 1 1 0 1 1 1 1 Tetratricopeptide repeat PP-binding PF00550.25 CCF42692.1 - 0.00076 19.8 0.0 0.0015 18.9 0.0 1.5 1 1 0 1 1 1 1 Phosphopantetheine attachment site Transp_cyt_pur PF02133.15 CCF42694.1 - 2.4e-34 118.9 14.4 2.6e-34 118.8 14.4 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Sm_multidrug_ex PF06695.11 CCF42694.1 - 0.038 14.6 1.5 0.05 14.3 0.1 1.9 2 1 1 3 3 3 0 Putative small multi-drug export protein PAT1 PF09770.9 CCF42696.1 - 0 1355.2 4.9 0 1355.0 4.9 1.0 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 T3SS_needle_F PF09392.10 CCF42696.1 - 0.11 12.7 0.2 0.31 11.3 0.2 1.8 1 0 0 1 1 1 0 Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF Glyco_transf_15 PF01793.16 CCF42697.1 - 1.3e-143 478.2 8.2 1.6e-143 477.8 8.2 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Ribosom_S12_S23 PF00164.25 CCF42698.1 - 1.6e-29 101.8 0.8 2.1e-29 101.4 0.8 1.2 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Acyl-CoA_dh_1 PF00441.24 CCF42699.1 - 3.4e-40 137.7 3.4 5.7e-40 137.0 3.4 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 CCF42699.1 - 4.1e-29 101.5 0.2 1e-28 100.2 0.0 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 CCF42699.1 - 2.8e-23 81.9 0.0 5.2e-23 81.1 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 CCF42699.1 - 5.7e-18 65.5 0.5 1e-17 64.6 0.5 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.8 CCF42699.1 - 0.0097 15.6 0.0 0.026 14.2 0.0 1.7 1 1 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase N terminal AgrD PF05931.11 CCF42699.1 - 0.025 14.6 0.2 0.08 13.0 0.0 1.9 2 0 0 2 2 2 0 Staphylococcal AgrD protein Peptidase_M14 PF00246.24 CCF42700.1 - 1.1e-82 278.1 0.1 1.2e-82 278.0 0.1 1.0 1 0 0 1 1 1 1 Zinc carboxypeptidase Cellulase PF00150.18 CCF42701.1 - 0.0058 16.1 0.1 0.0093 15.4 0.1 1.4 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) DUF4219 PF13961.6 CCF42701.1 - 0.17 11.6 1.5 1.5 8.6 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4219) DUF1712 PF08217.11 CCF42703.1 - 2.3e-13 49.5 0.0 1e-12 47.4 0.0 2.0 2 1 0 2 2 2 1 Fungal domain of unknown function (DUF1712) TPR_14 PF13428.6 CCF42704.1 - 1.7e-06 28.3 6.7 0.00025 21.6 2.1 4.1 3 2 2 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 CCF42704.1 - 0.00081 20.0 0.1 0.0042 17.7 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat HrpJ PF07201.11 CCF42704.1 - 0.0043 17.4 0.7 2.2 8.5 0.1 2.4 2 0 0 2 2 2 2 HrpJ-like domain TPR_19 PF14559.6 CCF42704.1 - 0.0081 16.7 1.2 0.025 15.1 0.0 2.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 CCF42704.1 - 0.023 14.8 0.2 0.07 13.3 0.2 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat HAT PF02184.16 CCF42704.1 - 0.038 14.0 0.0 0.038 14.0 0.0 3.1 3 0 0 3 3 3 0 HAT (Half-A-TPR) repeat TPR_17 PF13431.6 CCF42704.1 - 0.092 13.2 0.0 0.51 10.9 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat Suf PF05843.14 CCF42704.1 - 0.11 12.5 0.2 7.3 6.5 0.1 2.5 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Fungal_trans_2 PF11951.8 CCF42705.1 - 6.8e-09 35.0 0.1 8.6e-09 34.7 0.1 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF42706.1 - 5.2e-09 36.1 7.5 1.2e-08 34.9 7.5 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CCF42706.1 - 0.00053 19.1 0.5 0.00053 19.1 0.5 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain Nop PF01798.18 CCF42707.1 - 4.8e-77 258.5 0.1 4.8e-77 258.5 0.1 2.3 2 1 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 CCF42707.1 - 0.03 14.7 0.2 0.03 14.7 0.2 3.1 3 0 0 3 3 3 0 NOP5NT (NUC127) domain ANAPC10 PF03256.16 CCF42709.1 - 9.9e-50 168.7 0.0 1.5e-49 168.2 0.0 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) F5_F8_type_C PF00754.25 CCF42709.1 - 0.03 14.4 0.1 0.084 13.0 0.1 1.9 1 1 0 1 1 1 0 F5/8 type C domain HET PF06985.11 CCF42710.1 - 2.3e-33 115.6 0.0 3.3e-33 115.1 0.0 1.3 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) GARS_A PF01071.19 CCF42711.1 - 2.6e-75 252.5 0.0 3.5e-75 252.1 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain GARS_N PF02844.15 CCF42711.1 - 2e-30 105.4 0.0 3.9e-30 104.5 0.0 1.5 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, N domain GARS_C PF02843.16 CCF42711.1 - 1.5e-28 98.9 0.9 7.2e-28 96.7 0.7 2.3 3 0 0 3 3 3 1 Phosphoribosylglycinamide synthetase, C domain CPSase_L_D2 PF02786.17 CCF42711.1 - 2.9e-05 23.7 0.0 7.9e-05 22.2 0.0 1.7 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Dala_Dala_lig_C PF07478.13 CCF42711.1 - 0.00021 20.9 0.0 0.00035 20.2 0.0 1.3 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.14 CCF42711.1 - 0.0015 18.6 0.0 0.0083 16.2 0.0 2.0 2 1 0 2 2 2 1 ATP-grasp domain ATP-grasp_4 PF13535.6 CCF42711.1 - 0.013 15.1 0.0 0.024 14.3 0.0 1.4 1 0 0 1 1 1 0 ATP-grasp domain RimK PF08443.11 CCF42711.1 - 0.18 11.4 0.0 0.31 10.6 0.0 1.3 1 0 0 1 1 1 0 RimK-like ATP-grasp domain Leucyl-specific PF14795.6 CCF42712.1 - 0.17 12.0 0.3 1.3 9.1 0.0 2.5 3 0 0 3 3 3 0 Leucine-tRNA synthetase-specific domain Glyco_hydro_42 PF02449.15 CCF42713.1 - 1.4e-11 44.3 0.0 2.1e-11 43.8 0.0 1.2 1 0 0 1 1 1 1 Beta-galactosidase Glyco_hydro_35 PF01301.19 CCF42713.1 - 7.1e-08 32.4 0.0 1.7e-05 24.6 0.0 2.1 2 0 0 2 2 2 2 Glycosyl hydrolases family 35 Glyco_hydro_10 PF00331.20 CCF42713.1 - 0.072 12.2 0.0 0.099 11.8 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 10 DUF3295 PF11702.8 CCF42714.1 - 8.2e-168 559.8 29.9 1e-167 559.5 29.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3295) DUF1752 PF08550.10 CCF42714.1 - 8.9e-13 47.8 2.0 2.5e-12 46.4 2.0 1.8 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) AhpC-TSA PF00578.21 CCF42716.1 - 0.0002 21.3 0.0 0.00025 21.0 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family AhpC-TSA_2 PF13911.6 CCF42716.1 - 0.00021 21.4 0.0 0.00029 20.9 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme Redoxin PF08534.10 CCF42716.1 - 0.00031 20.5 0.0 0.00046 19.9 0.0 1.3 1 1 0 1 1 1 1 Redoxin DUF2427 PF10348.9 CCF42717.1 - 3.9e-05 23.4 1.2 6.7e-05 22.6 0.3 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF2427) Abhydrolase_1 PF00561.20 CCF42719.1 - 1.4e-21 77.3 0.1 4.6e-21 75.6 0.1 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCF42719.1 - 2.7e-16 60.9 5.3 4.2e-16 60.2 5.3 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCF42719.1 - 8.7e-10 38.3 0.1 1.2e-09 37.8 0.1 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.14 CCF42719.1 - 0.0031 16.3 0.0 0.005 15.6 0.0 1.3 1 0 0 1 1 1 1 Ndr family peroxidase PF00141.23 CCF42720.1 - 3.1e-24 85.9 0.0 4.7e-24 85.3 0.0 1.2 1 0 0 1 1 1 1 Peroxidase Actino_peptide PF14408.6 CCF42720.1 - 0.41 10.8 1.9 0.82 9.8 0.3 2.1 2 0 0 2 2 2 0 Ribosomally synthesised peptide in actinomycetes Ribosomal_L18_c PF14204.6 CCF42723.1 - 3.2e-36 124.1 10.5 4e-36 123.8 10.5 1.1 1 0 0 1 1 1 1 Ribosomal L18 C-terminal region Ribosomal_L5e PF17144.4 CCF42723.1 - 3.7e-14 53.0 0.0 3.7e-14 53.0 0.0 1.8 2 0 0 2 2 2 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Uteroglobin PF01099.17 CCF42723.1 - 0.94 9.9 5.1 1 9.7 0.2 2.2 2 0 0 2 2 2 0 Uteroglobin family Tli4_N PF18443.1 CCF42723.1 - 1 9.7 5.6 1 9.7 1.6 2.2 2 1 0 2 2 2 0 Tle cognate immunity protein 4 N-terminal domain Transp_cyt_pur PF02133.15 CCF42724.1 - 6.1e-65 219.7 25.1 7.4e-65 219.4 25.1 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin S1FA PF04689.13 CCF42724.1 - 0.19 11.9 0.2 0.19 11.9 0.2 2.3 3 0 0 3 3 3 0 DNA binding protein S1FA DAO PF01266.24 CCF42725.1 - 3.2e-07 30.3 0.1 3.2e-07 30.3 0.1 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CCF42725.1 - 4.8e-07 29.9 0.3 8.7e-07 29.1 0.3 1.4 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CCF42725.1 - 5.4e-05 22.6 0.1 5.4e-05 22.6 0.1 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CCF42725.1 - 0.00013 21.2 0.2 0.00013 21.2 0.2 1.1 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 CCF42725.1 - 0.0013 17.6 0.1 0.0016 17.2 0.1 1.1 1 0 0 1 1 1 1 HI0933-like protein AlaDh_PNT_C PF01262.21 CCF42725.1 - 0.003 16.9 0.3 0.0035 16.7 0.3 1.1 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_3 PF01494.19 CCF42725.1 - 0.0036 16.6 0.3 0.0037 16.6 0.3 1.1 1 0 0 1 1 1 1 FAD binding domain Trp_halogenase PF04820.14 CCF42725.1 - 0.0088 14.9 0.1 0.0088 14.9 0.1 1.1 1 0 0 1 1 1 1 Tryptophan halogenase GIDA PF01134.22 CCF42725.1 - 0.01 15.0 0.3 0.01 15.0 0.3 1.1 1 0 0 1 1 1 0 Glucose inhibited division protein A Thi4 PF01946.17 CCF42725.1 - 0.012 14.8 0.1 0.014 14.6 0.1 1.1 1 0 0 1 1 1 0 Thi4 family TrkA_N PF02254.18 CCF42725.1 - 0.014 15.6 0.1 0.022 15.0 0.0 1.4 1 1 0 1 1 1 0 TrkA-N domain Pyr_redox PF00070.27 CCF42725.1 - 0.025 15.1 0.1 0.029 14.9 0.1 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 CCF42725.1 - 0.045 13.1 0.6 0.056 12.8 0.6 1.1 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 CCF42725.1 - 0.074 12.3 0.1 0.094 11.9 0.1 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 CCF42725.1 - 0.097 11.7 0.2 0.11 11.5 0.2 1.1 1 0 0 1 1 1 0 Lycopene cyclase protein NmrA PF05368.13 CCF42727.1 - 6.6e-33 114.2 0.0 8.2e-33 113.9 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CCF42727.1 - 9.3e-13 48.5 0.1 1.1e-12 48.2 0.1 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CCF42727.1 - 3.1e-05 23.6 0.0 0.00022 20.8 0.0 1.9 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family KR PF08659.10 CCF42727.1 - 0.00043 20.3 0.1 0.00068 19.6 0.1 1.4 1 0 0 1 1 1 1 KR domain 3Beta_HSD PF01073.19 CCF42727.1 - 0.0011 18.1 0.0 0.0015 17.6 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 CCF42727.1 - 0.0044 16.5 0.0 0.0061 16.0 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase adh_short PF00106.25 CCF42727.1 - 0.014 14.8 0.0 0.022 14.2 0.0 1.3 1 0 0 1 1 1 0 short chain dehydrogenase DapB_N PF01113.20 CCF42727.1 - 0.015 15.4 0.0 0.03 14.4 0.0 1.6 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus NAD_binding_4 PF07993.12 CCF42727.1 - 0.1 11.8 0.0 0.17 11.0 0.0 1.3 1 0 0 1 1 1 0 Male sterility protein F-box PF00646.33 CCF42728.1 - 0.0025 17.6 0.1 0.0064 16.4 0.1 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 CCF42728.1 - 0.024 14.5 0.1 0.061 13.2 0.1 1.7 1 0 0 1 1 1 0 F-box-like DOT1 PF08123.13 CCF42729.1 - 1.2e-73 247.0 0.0 1.7e-73 246.6 0.0 1.2 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_32 PF13679.6 CCF42729.1 - 0.057 13.4 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 CCF42729.1 - 0.09 13.5 0.0 0.21 12.3 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain ATG16 PF08614.11 CCF42730.1 - 3e-56 190.8 27.0 3.4e-56 190.7 27.0 1.0 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Mod_r PF07200.13 CCF42730.1 - 0.041 14.0 15.9 0.041 14.0 12.9 2.3 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein PhyH PF05721.13 CCF42730.1 - 0.079 13.2 1.7 0.12 12.6 1.7 1.3 1 0 0 1 1 1 0 Phytanoyl-CoA dioxygenase (PhyH) Fez1 PF06818.15 CCF42730.1 - 0.079 13.4 18.8 0.5 10.8 2.3 2.1 1 1 1 2 2 2 0 Fez1 DUF724 PF05266.14 CCF42730.1 - 0.17 11.7 17.0 0.12 12.2 12.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF724) SurA_N PF09312.11 CCF42730.1 - 0.18 11.9 9.3 0.07 13.2 4.2 2.4 1 1 1 2 2 2 0 SurA N-terminal domain LAGLIDADG_WhiA PF14527.6 CCF42730.1 - 0.25 11.4 4.1 0.16 12.0 2.3 1.7 2 0 0 2 2 2 0 WhiA LAGLIDADG-like domain DUF3584 PF12128.8 CCF42730.1 - 0.67 7.4 24.5 0.28 8.7 20.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) HAUS-augmin3 PF14932.6 CCF42730.1 - 2.9 7.4 16.1 0.61 9.6 11.1 2.0 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 3 AAA_13 PF13166.6 CCF42730.1 - 3 6.4 15.0 4.6 5.8 15.0 1.3 1 1 0 1 1 1 0 AAA domain UPF0242 PF06785.11 CCF42730.1 - 3.1 7.8 17.1 6 6.9 3.6 2.2 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus MPS2 PF17060.5 CCF42730.1 - 3.7 6.7 16.2 0.6 9.3 9.0 2.0 1 1 1 2 2 2 0 Monopolar spindle protein 2 DUF4407 PF14362.6 CCF42730.1 - 4.1 6.7 16.2 13 5.1 16.2 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) TMPIT PF07851.13 CCF42730.1 - 5 6.3 6.3 8.4 5.5 6.3 1.4 1 0 0 1 1 1 0 TMPIT-like protein APG6_N PF17675.1 CCF42730.1 - 5.7 7.5 26.4 45 4.6 23.7 2.7 1 1 1 2 2 2 0 Apg6 coiled-coil region Fmp27_WPPW PF10359.9 CCF42730.1 - 9.4 5.0 14.3 1.1 8.1 10.5 1.4 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain Vps16_C PF04840.12 CCF42732.1 - 1.6e-70 237.7 0.1 2e-70 237.4 0.1 1.1 1 0 0 1 1 1 1 Vps16, C-terminal region p450 PF00067.22 CCF42734.1 - 6.4e-49 166.9 0.0 8.9e-49 166.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 DUF5050 PF16472.5 CCF42735.1 - 0.016 14.5 0.0 0.022 14.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5050) Ldl_recept_b PF00058.17 CCF42735.1 - 0.041 14.4 0.0 3.1 8.4 0.0 2.8 3 0 0 3 3 3 0 Low-density lipoprotein receptor repeat class B NPCBM_assoc PF10633.9 CCF42736.1 - 0.046 14.0 0.3 0.46 10.8 0.0 2.4 2 0 0 2 2 2 0 NPCBM-associated, NEW3 domain of alpha-galactosidase Cation_ATPase_C PF00689.21 CCF42737.1 - 3.3e-41 141.0 7.6 4.5e-41 140.5 3.3 2.3 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 CCF42737.1 - 7.5e-38 129.9 1.9 7.5e-38 129.9 1.9 1.7 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase PF13246.6 CCF42737.1 - 1.4e-18 66.8 0.0 3.3e-18 65.6 0.0 1.7 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 CCF42737.1 - 7e-18 65.7 0.9 1.3e-16 61.6 0.9 2.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 CCF42737.1 - 8e-06 25.8 0.3 0.00011 22.0 0.6 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Dak1_2 PF13684.6 CCF42737.1 - 0.046 12.8 0.3 0.094 11.8 0.3 1.5 1 0 0 1 1 1 0 Dihydroxyacetone kinase family Glycophorin_A PF01102.18 CCF42737.1 - 0.064 13.5 0.2 0.24 11.6 0.0 2.0 1 1 1 2 2 2 0 Glycophorin A UPF0086 PF01868.16 CCF42739.1 - 4.1e-28 97.1 0.0 6.1e-28 96.6 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function UPF0086 MFS_1 PF07690.16 CCF42741.1 - 4.4e-13 48.9 25.4 2.6e-12 46.3 25.4 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 CCF42741.1 - 8.8e-06 24.4 9.4 0.0072 14.8 0.2 2.1 2 0 0 2 2 2 2 Fungal trichothecene efflux pump (TRI12) DUF4538 PF15061.6 CCF42741.1 - 0.0026 17.4 2.3 0.0075 16.0 2.3 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4538) SBF PF01758.16 CCF42743.1 - 2.1e-48 164.6 12.1 2.1e-48 164.6 12.1 2.2 2 1 1 3 3 3 1 Sodium Bile acid symporter family Kinocilin PF15033.6 CCF42743.1 - 0.17 11.6 5.3 5.6 6.6 0.9 2.8 2 0 0 2 2 2 0 Kinocilin protein GT87 PF09594.10 CCF42746.1 - 0.0025 17.6 2.7 0.0027 17.5 2.7 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 87 ACC_central PF08326.12 CCF42747.1 - 5e-159 530.9 0.0 6e-159 530.6 0.0 1.0 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region TetR_C_9 PF14514.6 CCF42747.1 - 0.047 13.8 0.0 0.13 12.4 0.0 1.7 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain PUNUT PF16913.5 CCF42750.1 - 1.9e-06 27.4 0.1 2.9e-06 26.7 0.1 1.2 1 0 0 1 1 1 1 Purine nucleobase transmembrane transport EamA PF00892.20 CCF42750.1 - 8.1e-06 26.0 0.8 1.3e-05 25.4 0.1 1.7 2 0 0 2 2 2 1 EamA-like transporter family Mg_trans_NIPA PF05653.14 CCF42750.1 - 0.00032 19.9 0.2 0.00041 19.6 0.2 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA COX4_pro_2 PF07835.12 CCF42750.1 - 0.021 14.9 0.2 0.021 14.9 0.2 1.7 2 0 0 2 2 2 0 Bacterial aa3 type cytochrome c oxidase subunit IV Neurensin PF14927.6 CCF42750.1 - 0.028 14.1 0.5 0.064 13.0 0.5 1.9 1 1 0 1 1 1 0 Neurensin 7TMR-DISM_7TM PF07695.11 CCF42750.1 - 0.028 14.3 1.9 0.039 13.9 1.9 1.3 1 1 0 1 1 1 0 7TM diverse intracellular signalling DMT_6 PF04342.12 CCF42750.1 - 0.063 13.5 0.1 0.095 12.9 0.1 1.2 1 0 0 1 1 1 0 Putative member of DMT superfamily (DUF486) UAA PF08449.11 CCF42750.1 - 0.064 12.5 0.1 0.095 11.9 0.1 1.3 1 1 0 1 1 1 0 UAA transporter family vATP-synt_E PF01991.18 CCF42751.1 - 7.3e-70 234.4 10.6 8.4e-70 234.2 10.6 1.0 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit Peptidase_M32 PF02074.15 CCF42751.1 - 1.9 7.2 8.0 2.2 7.0 8.0 1.1 1 0 0 1 1 1 0 Carboxypeptidase Taq (M32) metallopeptidase PhoLip_ATPase_C PF16212.5 CCF42752.1 - 8.8e-66 222.2 22.4 1.2e-65 221.7 22.4 1.1 1 0 0 1 1 1 1 Phospholipid-translocating P-type ATPase C-terminal Cation_ATPase PF13246.6 CCF42752.1 - 2.2e-11 43.7 0.0 3.6e-10 39.8 0.0 2.4 2 1 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 CCF42752.1 - 1.9e-10 41.4 0.4 5.6e-06 26.8 0.0 3.5 4 0 0 4 4 4 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 CCF42752.1 - 0.0091 15.8 0.0 0.038 13.7 0.0 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF4077 PF13295.6 CCF42752.1 - 0.55 10.1 5.6 0.25 11.3 0.1 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4077) Pkinase PF00069.25 CCF42754.1 - 1.5e-23 83.5 0.0 1.6e-22 80.2 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF42754.1 - 1e-05 25.0 0.1 0.026 13.8 0.0 2.5 2 1 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 CCF42754.1 - 0.13 11.0 0.0 0.19 10.4 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase DUF2551 PF10826.8 CCF42754.1 - 0.16 12.2 0.0 0.31 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2551) Aa_trans PF01490.18 CCF42755.1 - 2.8e-16 59.3 6.4 3.6e-16 58.9 6.4 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein UvdE PF03851.14 CCF42756.1 - 1.1e-112 375.8 0.0 1.4e-112 375.5 0.0 1.1 1 0 0 1 1 1 1 UV-endonuclease UvdE DUF5323 PF17257.2 CCF42756.1 - 0.015 15.2 7.4 0.77 9.7 0.0 3.2 3 0 0 3 3 3 0 Family of unknown function (DUF5323) BCMA-Tall_bind PF09257.10 CCF42756.1 - 1.1 9.4 3.5 0.48 10.6 0.3 2.0 2 0 0 2 2 2 0 BCMA, TALL-1 binding Gp_dh_C PF02800.20 CCF42758.1 - 5.7e-71 237.2 0.1 8.7e-71 236.6 0.1 1.3 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 CCF42758.1 - 5.3e-40 135.8 0.1 1.2e-39 134.7 0.1 1.6 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.20 CCF42758.1 - 0.0014 18.8 0.1 0.0052 16.9 0.1 2.1 1 1 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus ADH_zinc_N PF00107.26 CCF42758.1 - 0.034 14.1 0.0 0.07 13.1 0.0 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 CCF42758.1 - 0.08 12.3 0.1 0.25 10.7 0.0 1.7 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain YDG PF18657.1 CCF42758.1 - 2.6 8.3 6.2 0.26 11.5 0.3 2.4 3 1 1 4 4 4 0 YDG domain DUF1690 PF07956.11 CCF42759.1 - 1.5e-14 54.6 5.0 1.7e-11 44.7 2.5 2.1 2 0 0 2 2 2 2 Protein of Unknown function (DUF1690) COesterase PF00135.28 CCF42760.1 - 2.3e-79 267.6 0.0 7.1e-72 242.9 0.0 2.0 1 1 1 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.13 CCF42760.1 - 2.3e-14 53.8 0.0 3.6e-14 53.1 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold ADH_zinc_N PF00107.26 CCF42761.1 - 4.3e-22 78.5 0.0 8e-22 77.6 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCF42761.1 - 1.4e-21 76.4 0.4 2.4e-21 75.6 0.4 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Glu_dehyd_C PF16912.5 CCF42761.1 - 4.1e-09 36.2 0.0 6.2e-09 35.7 0.0 1.2 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 CCF42761.1 - 4.9e-08 34.1 0.0 1.2e-07 32.8 0.0 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 CCF42761.1 - 0.00055 19.3 0.3 0.0011 18.3 0.3 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain TrkA_N PF02254.18 CCF42761.1 - 0.03 14.6 0.1 0.055 13.7 0.1 1.4 1 0 0 1 1 1 0 TrkA-N domain Methyltransf_25 PF13649.6 CCF42761.1 - 0.073 13.8 0.0 0.15 12.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain p450 PF00067.22 CCF42763.1 - 3.1e-53 181.1 0.0 3.6e-53 181.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF829 PF05705.14 CCF42764.1 - 5e-47 160.8 0.0 5.8e-47 160.6 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF829) Pyr_redox_2 PF07992.14 CCF42765.1 - 1.9e-14 53.6 0.0 1.5e-10 40.9 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCF42765.1 - 8.6e-12 44.9 0.0 2.2e-11 43.6 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 CCF42765.1 - 5.6e-10 38.2 0.0 1.1e-09 37.3 0.0 1.4 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox PF00070.27 CCF42765.1 - 2.5e-05 24.8 0.1 0.0037 17.8 0.0 2.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 CCF42765.1 - 5.7e-05 22.3 0.7 0.002 17.2 0.8 2.7 2 1 0 2 2 2 1 Lycopene cyclase protein DAO PF01266.24 CCF42765.1 - 0.00044 19.9 0.6 0.92 9.0 0.2 2.6 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CCF42765.1 - 0.00045 20.4 0.0 0.0067 16.6 0.0 2.8 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 CCF42765.1 - 0.00065 18.5 0.1 0.0061 15.3 0.0 2.3 3 0 0 3 3 3 1 HI0933-like protein FAD_binding_3 PF01494.19 CCF42765.1 - 0.0012 18.1 0.5 0.0022 17.3 0.1 1.6 2 0 0 2 2 2 1 FAD binding domain NAD_binding_9 PF13454.6 CCF42765.1 - 0.0032 17.5 0.1 18 5.3 0.0 3.3 3 0 0 3 3 3 0 FAD-NAD(P)-binding TrkA_N PF02254.18 CCF42765.1 - 0.036 14.3 0.0 0.068 13.4 0.0 1.4 1 0 0 1 1 1 0 TrkA-N domain FAD_binding_2 PF00890.24 CCF42765.1 - 0.06 12.4 1.0 0.096 11.7 0.4 1.6 2 0 0 2 2 2 0 FAD binding domain Cofilin_ADF PF00241.20 CCF42766.1 - 9.4e-26 90.0 0.0 1e-25 89.8 0.0 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein DUF3656 PF12392.8 CCF42766.1 - 0.06 14.0 0.0 0.088 13.5 0.0 1.3 1 0 0 1 1 1 0 Collagenase Aspzincin_M35 PF14521.6 CCF42767.1 - 4.6e-05 24.0 0.7 0.0028 18.2 0.7 3.2 1 1 0 1 1 1 1 Lysine-specific metallo-endopeptidase HRXXH PF13933.6 CCF42767.1 - 0.017 14.7 0.0 0.29 10.7 0.0 2.3 2 0 0 2 2 2 0 Putative peptidase family Polysacc_deac_1 PF01522.21 CCF42768.1 - 9.8e-31 106.2 0.2 1.7e-30 105.4 0.1 1.5 2 0 0 2 2 2 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.15 CCF42768.1 - 3.2e-05 23.3 0.0 6.4e-05 22.3 0.0 1.5 1 1 0 1 1 1 1 Glycosyl hydrolase family 57 MFS_1 PF07690.16 CCF42769.1 - 3.8e-39 134.6 37.0 3.8e-39 134.6 37.0 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Pre-PUA PF17832.1 CCF42770.1 - 5.4e-22 78.3 0.8 8.1e-22 77.7 0.8 1.2 1 0 0 1 1 1 1 Pre-PUA-like domain PUA PF01472.20 CCF42770.1 - 3.2e-14 52.6 0.1 1.6e-13 50.4 0.1 1.9 1 1 0 1 1 1 1 PUA domain Inhibitor_I78 PF11720.8 CCF42771.1 - 6.4e-11 42.2 0.0 8.2e-11 41.8 0.0 1.1 1 0 0 1 1 1 1 Peptidase inhibitor I78 family potato_inhibit PF00280.18 CCF42771.1 - 0.0018 18.9 0.0 0.0022 18.6 0.0 1.3 1 0 0 1 1 1 1 Potato inhibitor I family Fn3-like PF14310.6 CCF42772.1 - 8.7e-26 89.8 0.2 1.3e-25 89.3 0.2 1.2 1 0 0 1 1 1 1 Fibronectin type III-like domain CVNH PF08881.10 CCF42773.1 - 3.1e-13 50.3 0.6 6.4e-13 49.3 0.3 1.7 2 0 0 2 2 2 1 CVNH domain Methyltransf_23 PF13489.6 CCF42774.1 - 1.3e-17 64.1 0.0 2.7e-17 63.1 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF42774.1 - 3.5e-13 50.1 0.0 8.5e-13 48.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF42774.1 - 1.1e-09 38.9 0.0 3.4e-09 37.3 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF42774.1 - 1.2e-09 38.6 0.0 2.5e-09 37.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF42774.1 - 7.7e-09 35.5 0.0 3.4e-08 33.4 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 CCF42774.1 - 5e-05 22.8 0.0 0.00021 20.8 0.0 1.9 2 0 0 2 2 2 1 Putative methyltransferase MTS PF05175.14 CCF42774.1 - 0.00013 21.6 0.0 0.0018 17.9 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_2 PF00891.18 CCF42774.1 - 0.00026 20.4 0.0 0.0047 16.3 0.0 2.3 2 0 0 2 2 2 1 O-methyltransferase domain Ubie_methyltran PF01209.18 CCF42774.1 - 0.00082 18.8 0.0 0.0022 17.3 0.0 1.6 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family CMAS PF02353.20 CCF42774.1 - 0.046 13.0 0.0 0.11 11.8 0.0 1.8 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase FtsJ PF01728.19 CCF42774.1 - 0.052 13.7 0.0 0.085 13.0 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase Amidohydro_3 PF07969.11 CCF42775.1 - 0.0025 17.3 0.0 0.0026 17.3 0.0 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_1 PF01979.20 CCF42775.1 - 0.041 13.2 0.1 0.048 13.0 0.1 1.0 1 0 0 1 1 1 0 Amidohydrolase family Aa_trans PF01490.18 CCF42777.1 - 1e-19 70.6 5.2 1.2e-19 70.3 5.2 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein SNARE PF05739.19 CCF42779.1 - 1.8e-13 50.3 0.1 3.9e-13 49.2 0.1 1.6 1 0 0 1 1 1 1 SNARE domain Syntaxin-5_N PF11416.8 CCF42779.1 - 2.2e-09 36.3 0.3 5.9e-09 34.9 0.3 1.8 1 0 0 1 1 1 1 Syntaxin-5 N-terminal, Sly1p-binding domain Syntaxin PF00804.25 CCF42779.1 - 0.00032 20.4 5.2 0.0019 17.9 0.1 2.8 2 1 1 3 3 3 1 Syntaxin KxDL PF10241.9 CCF42779.1 - 0.0034 17.6 4.7 0.75 10.1 0.1 3.7 4 0 0 4 4 4 2 Uncharacterized conserved protein Prominin PF05478.11 CCF42779.1 - 0.0045 15.0 1.5 0.59 8.0 0.0 2.2 2 0 0 2 2 2 2 Prominin SF-assemblin PF06705.11 CCF42779.1 - 0.012 15.0 5.4 0.021 14.2 1.3 2.3 2 0 0 2 2 2 0 SF-assemblin/beta giardin Baculo_PEP_C PF04513.12 CCF42779.1 - 0.012 15.6 3.4 8.5 6.4 0.1 3.2 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Syntaxin-18_N PF10496.9 CCF42779.1 - 0.089 13.1 2.2 0.53 10.6 0.1 2.5 2 0 0 2 2 2 0 SNARE-complex protein Syntaxin-18 N-terminus DUF4988 PF16378.5 CCF42779.1 - 0.19 11.4 3.8 8.2 6.1 0.0 3.0 2 1 1 3 3 3 0 Domain of unknown function DUF16 PF01519.16 CCF42779.1 - 0.25 11.9 4.7 1.4 9.5 0.1 2.5 2 1 0 2 2 2 0 Protein of unknown function DUF16 SlyX PF04102.12 CCF42779.1 - 0.34 11.5 0.2 0.34 11.5 0.2 3.3 3 1 0 3 3 3 0 SlyX TRPM_tetra PF16519.5 CCF42779.1 - 0.45 10.7 2.3 1.5 9.0 0.2 2.9 4 0 0 4 4 4 0 Tetramerisation domain of TRPM Muted PF14942.6 CCF42779.1 - 0.79 10.1 5.9 0.93 9.8 1.8 2.5 2 1 0 2 2 2 0 Organelle biogenesis, Muted-like protein MCPsignal PF00015.21 CCF42779.1 - 0.81 9.5 5.6 0.38 10.5 1.1 2.3 2 1 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain NPV_P10 PF05531.12 CCF42779.1 - 0.94 10.0 5.6 14 6.2 0.1 3.4 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Zip PF02535.22 CCF42780.1 - 5.4e-08 32.4 1.6 5.6e-08 32.4 1.6 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter adh_short PF00106.25 CCF42781.1 - 8.6e-21 74.3 0.1 1.2e-20 73.8 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF42781.1 - 4e-14 52.7 0.0 4.9e-14 52.4 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short_C2 PF13561.6 CCF42782.1 - 1.6e-42 145.6 0.4 1.4e-41 142.6 0.4 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF42782.1 - 3.6e-25 88.6 0.3 1.3e-24 86.8 0.3 1.7 1 1 0 1 1 1 1 short chain dehydrogenase APH PF01636.23 CCF42783.1 - 2.1e-09 37.7 0.1 5.1e-09 36.4 0.0 1.6 2 0 0 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CCF42783.1 - 0.003 17.2 0.0 0.0044 16.6 0.0 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase He_PIG PF05345.12 CCF42783.1 - 0.31 11.2 2.1 6.8 7.0 1.1 2.5 2 0 0 2 2 2 0 Putative Ig domain p450 PF00067.22 CCF42784.1 - 6.7e-27 94.4 0.0 8.2e-27 94.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 DUF3536 PF12055.8 CCF42784.1 - 0.057 12.7 0.8 0.11 11.8 0.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3536) Bul1_C PF04426.12 CCF42785.1 - 0.0067 15.9 0.0 0.0098 15.3 0.0 1.2 1 0 0 1 1 1 1 Bul1 C terminus Arrestin_N PF00339.29 CCF42785.1 - 0.012 15.7 0.2 0.062 13.3 0.2 2.0 1 1 0 1 1 1 0 Arrestin (or S-antigen), N-terminal domain Bul1_N PF04425.12 CCF42785.1 - 0.1 11.3 0.1 0.23 10.2 0.1 1.5 2 0 0 2 2 2 0 Bul1 N terminus Sugar_tr PF00083.24 CCF42786.1 - 1.7e-66 225.0 29.1 2e-66 224.7 29.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF42786.1 - 5.4e-16 58.5 52.9 2e-11 43.5 20.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily HTH_Tnp_Tc5 PF03221.16 CCF42787.1 - 0.11 12.5 0.6 1.3 9.1 0.2 2.7 2 1 0 2 2 2 0 Tc5 transposase DNA-binding domain DUF2076 PF09849.9 CCF42787.1 - 0.18 11.8 1.2 0.26 11.3 1.2 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) AMP-binding PF00501.28 CCF42788.1 - 1.1e-12 47.3 0.0 1.8e-12 46.6 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme Condensation PF00668.20 CCF42788.1 - 9.4e-07 27.9 0.1 0.0065 15.2 0.1 2.1 2 0 0 2 2 2 2 Condensation domain Hydant_A_N PF05378.13 CCF42789.1 - 3.8e-06 26.7 0.0 4.2e-06 26.6 0.0 1.0 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase N-terminal region BcrAD_BadFG PF01869.20 CCF42789.1 - 0.037 13.5 0.0 0.037 13.5 0.0 1.0 1 0 0 1 1 1 0 BadF/BadG/BcrA/BcrD ATPase family Hydantoinase_A PF01968.18 CCF42789.1 - 0.075 12.3 0.0 0.077 12.2 0.0 1.0 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase Transp_cyt_pur PF02133.15 CCF42790.1 - 5.2e-100 335.3 30.3 5.9e-100 335.1 30.3 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin DUF1593 PF07632.11 CCF42791.1 - 5.1e-88 294.8 0.0 6.4e-88 294.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1593) Sds3 PF08598.11 CCF42793.1 - 2e-17 63.9 4.1 3.8e-17 63.0 4.1 1.5 1 1 0 1 1 1 1 Sds3-like Choline_kinase PF01633.20 CCF42794.1 - 5.4e-54 183.0 0.0 3.5e-53 180.4 0.0 1.9 2 0 0 2 2 2 1 Choline/ethanolamine kinase APH PF01636.23 CCF42794.1 - 6.8e-11 42.5 0.0 1.6e-10 41.3 0.0 1.6 2 0 0 2 2 2 1 Phosphotransferase enzyme family Glyco_hydro_10 PF00331.20 CCF42795.1 - 1.5e-95 320.0 0.1 1.7e-95 319.8 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 SSP160 PF06933.11 CCF42796.1 - 3 5.9 14.2 2.8 6.0 14.2 1.0 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 ADH_N PF08240.12 CCF42798.1 - 1e-25 89.7 2.9 1.6e-25 89.1 2.9 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCF42798.1 - 5.9e-15 55.4 0.0 3.2e-14 53.0 0.0 2.1 2 1 1 3 3 3 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 CCF42798.1 - 3.1e-05 23.4 0.2 5.7e-05 22.6 0.2 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ApbA PF02558.16 CCF42798.1 - 0.013 15.2 0.0 0.02 14.6 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA AlaDh_PNT_C PF01262.21 CCF42798.1 - 0.09 12.1 0.1 0.44 9.8 0.0 2.0 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain ADH_zinc_N_2 PF13602.6 CCF42798.1 - 0.14 13.3 0.0 0.22 12.6 0.0 1.3 1 0 0 1 1 1 0 Zinc-binding dehydrogenase DNA_pol_phi PF04931.13 CCF42801.1 - 5.3 5.0 7.7 4.9 5.1 7.7 1.0 1 0 0 1 1 1 0 DNA polymerase phi Hap4_Hap_bind PF10297.9 CCF42803.1 - 9.2e-07 28.8 6.7 9.2e-07 28.8 6.7 2.1 2 0 0 2 2 2 1 Minimal binding motif of Hap4 for binding to Hap2/3/5 bZIP_1 PF00170.21 CCF42803.1 - 1.3e-06 28.3 5.6 2.8e-06 27.3 5.6 1.5 1 0 0 1 1 1 1 bZIP transcription factor dsrm PF00035.26 CCF42803.1 - 0.094 13.4 0.0 0.4 11.4 0.0 2.1 2 0 0 2 2 2 0 Double-stranded RNA binding motif RBM39linker PF15519.6 CCF42803.1 - 0.3 12.2 0.0 0.3 12.2 0.0 3.4 3 1 0 3 3 3 0 linker between RRM2 and RRM3 domains in RBM39 protein bZIP_2 PF07716.15 CCF42803.1 - 3.4 7.8 11.8 12 6.0 10.7 2.2 1 1 1 2 2 2 0 Basic region leucine zipper TPR_MLP1_2 PF07926.12 CCF42803.1 - 3.8 7.6 9.6 0.24 11.5 2.5 2.0 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein FAD_binding_7 PF03441.14 CCF42805.1 - 4.3e-77 258.2 1.2 5.8e-77 257.7 1.2 1.2 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase adh_short PF00106.25 CCF42806.1 - 1.1e-19 70.7 0.0 1.9e-15 56.9 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCF42806.1 - 6.6e-16 58.6 0.0 5.4e-15 55.6 0.0 2.0 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF42806.1 - 0.00013 22.0 0.1 0.00027 20.9 0.1 1.6 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF42806.1 - 0.00061 19.3 0.0 0.002 17.7 0.0 1.8 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 CCF42806.1 - 0.02 14.0 0.0 0.041 13.0 0.0 1.4 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein Zn_clus PF00172.18 CCF42807.1 - 8e-06 25.9 9.1 1.5e-05 25.0 9.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain HECT_2 PF09814.9 CCF42809.1 - 3.2e-59 200.7 0.0 3.6e-59 200.5 0.0 1.0 1 0 0 1 1 1 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding Glycos_transf_1 PF00534.20 CCF42811.1 - 8.9e-06 25.3 0.0 1.6e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Candida_ALS PF05792.13 CCF42812.1 - 2.6e-19 69.5 97.6 1.7e-07 31.7 8.1 16.4 16 1 1 17 17 17 10 Candida agglutinin-like (ALS) Collar PF07484.12 CCF42812.1 - 0.1 12.7 1.8 18 5.4 0.1 4.5 4 0 0 4 4 4 0 Phage Tail Collar Domain Actin PF00022.19 CCF42813.1 - 2.2e-18 66.1 0.0 6.4e-13 48.1 0.0 2.2 2 0 0 2 2 2 2 Actin PI3_PI4_kinase PF00454.27 CCF42814.1 - 6.1e-53 180.2 0.0 1e-52 179.5 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.23 CCF42814.1 - 1.7e-32 113.0 3.1 2.4e-32 112.5 3.1 1.2 1 0 0 1 1 1 1 FAT domain FATC PF02260.20 CCF42814.1 - 7.3e-17 60.9 0.0 1.3e-16 60.1 0.0 1.4 1 0 0 1 1 1 1 FATC domain Alkyl_sulf_dimr PF14863.6 CCF42814.1 - 0.17 12.4 0.6 0.4 11.1 0.6 1.7 1 0 0 1 1 1 0 Alkyl sulfatase dimerisation Ank_4 PF13637.6 CCF42815.1 - 3.4e-18 65.7 0.2 5.4e-09 36.4 0.0 4.7 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 CCF42815.1 - 8.5e-14 51.9 0.8 3.9e-07 30.6 0.1 3.6 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 CCF42815.1 - 1.3e-12 47.5 0.3 0.0024 18.2 0.1 4.8 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 CCF42815.1 - 2.3e-10 40.5 4.1 8.9e-07 29.1 0.2 3.9 5 0 0 5 5 5 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCF42815.1 - 1.5e-09 37.3 1.0 0.013 15.9 0.0 5.2 4 1 0 4 4 4 2 Ankyrin repeat Pkinase PF00069.25 CCF42816.1 - 1.2e-28 100.3 0.0 1.5e-28 99.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF42816.1 - 3.9e-14 52.6 0.0 7.3e-14 51.7 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CCF42816.1 - 0.015 14.1 0.0 0.022 13.5 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Pox_ser-thr_kin PF05445.11 CCF42816.1 - 0.19 10.6 0.0 0.27 10.1 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase DUF3449 PF11931.8 CCF42817.1 - 2.8e-68 229.3 0.0 3.3e-68 229.1 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3449) DUF951 PF06107.11 CCF42817.1 - 0.16 11.9 0.0 0.4 10.6 0.0 1.6 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF951) MFS_1 PF07690.16 CCF42819.1 - 4.8e-35 121.1 27.6 1.2e-34 119.8 27.9 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily Chromo PF00385.24 CCF42821.1 - 4.6e-08 32.9 7.6 1.4e-05 24.8 0.8 2.5 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain PWWP PF00855.17 CCF42821.1 - 0.074 13.5 0.0 0.23 11.9 0.0 1.8 1 0 0 1 1 1 0 PWWP domain BAF1_ABF1 PF04684.13 CCF42821.1 - 0.52 9.3 14.3 0.79 8.7 14.3 1.3 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor AT_hook PF02178.19 CCF42821.1 - 0.64 10.1 30.5 0.092 12.7 5.5 3.7 3 0 0 3 3 3 0 AT hook motif Abhydrolase_1 PF00561.20 CCF42822.1 - 2.6e-08 33.8 0.5 7.5e-08 32.3 0.4 1.7 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CCF42822.1 - 0.048 12.9 0.0 0.44 9.8 0.0 2.0 2 0 0 2 2 2 0 Serine aminopeptidase, S33 NUDIX PF00293.28 CCF42823.1 - 1.7e-18 66.9 0.4 2.1e-18 66.6 0.4 1.1 1 0 0 1 1 1 1 NUDIX domain Ribosomal_S24e PF01282.19 CCF42827.1 - 0.0094 15.9 0.6 0.034 14.1 0.3 2.1 1 1 1 2 2 2 1 Ribosomal protein S24e TetR_C_9 PF14514.6 CCF42827.1 - 0.092 12.9 0.0 0.14 12.3 0.0 1.3 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain 2OG-FeII_Oxy_3 PF13640.6 CCF42828.1 - 7.5e-09 36.4 0.0 1.5e-08 35.4 0.0 1.5 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily AAA_18 PF13238.6 CCF42829.1 - 2.8e-08 34.3 0.0 5.2e-08 33.5 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 CCF42829.1 - 0.0025 18.0 0.0 0.0035 17.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 CCF42829.1 - 0.033 14.2 0.0 2.1 8.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) CPT PF07931.12 CCF42829.1 - 0.1 12.4 0.1 0.25 11.2 0.1 1.9 1 1 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein DDE_1 PF03184.19 CCF42830.1 - 3.5e-26 91.9 0.0 6.1e-26 91.1 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 CCF42830.1 - 0.0005 19.9 0.0 0.0059 16.4 0.0 2.4 2 0 0 2 2 2 1 DDE superfamily endonuclease Mg_chelatase PF01078.21 CCF42830.1 - 0.05 13.0 0.0 0.08 12.3 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI zf-CCHC PF00098.23 CCF42830.1 - 0.68 10.1 3.2 1.6 8.9 3.2 1.7 1 0 0 1 1 1 0 Zinc knuckle Sec15 PF04091.12 CCF42831.1 - 1.9e-114 382.3 3.5 1.9e-114 382.3 3.5 2.0 2 0 0 2 2 2 1 Exocyst complex subunit Sec15-like DUF4201 PF13870.6 CCF42831.1 - 0.0011 18.7 6.7 0.0011 18.7 6.7 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4201) BORCS8 PF10167.9 CCF42831.1 - 0.095 12.7 2.7 0.55 10.2 1.0 2.8 2 0 0 2 2 2 0 BLOC-1-related complex sub-unit 8 DUF3510 PF12022.8 CCF42831.1 - 0.48 10.8 4.4 3.2 8.1 0.1 3.3 2 2 1 3 3 3 0 Domain of unknown function (DUF3510) COG2 PF06148.11 CCF42831.1 - 3 7.9 15.6 0.052 13.6 3.7 3.6 4 0 0 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 RRM_2 PF04059.12 CCF42833.1 - 3.9e-39 132.8 0.4 5.3e-39 132.3 0.4 1.2 1 0 0 1 1 1 1 RNA recognition motif 2 RRM_1 PF00076.22 CCF42833.1 - 0.032 14.1 0.0 0.057 13.2 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Sad1_UNC PF07738.13 CCF42834.1 - 6.9e-34 116.7 0.0 1.1e-33 116.1 0.0 1.3 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal AFG1_ATPase PF03969.16 CCF42835.1 - 1.9e-96 323.1 0.0 5.3e-92 308.5 0.0 2.0 2 0 0 2 2 2 2 AFG1-like ATPase Bac_DnaA PF00308.18 CCF42835.1 - 1e-05 25.5 1.0 0.088 12.6 0.1 2.6 2 1 0 2 2 2 2 Bacterial dnaA protein AAA_16 PF13191.6 CCF42835.1 - 2.1e-05 25.0 0.2 0.022 15.1 0.0 2.9 2 1 0 3 3 3 2 AAA ATPase domain AAA_22 PF13401.6 CCF42835.1 - 0.0013 19.0 0.1 0.028 14.7 0.0 2.6 2 1 0 2 2 2 1 AAA domain AAA_14 PF13173.6 CCF42835.1 - 0.0016 18.5 0.0 0.0036 17.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 CCF42835.1 - 0.0057 16.6 0.0 0.013 15.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA PF00004.29 CCF42835.1 - 0.012 16.1 0.0 0.034 14.6 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 CCF42835.1 - 0.041 14.3 0.0 0.12 12.8 0.0 1.9 2 0 0 2 2 2 0 RNA helicase NACHT PF05729.12 CCF42835.1 - 0.042 13.8 0.0 0.17 11.8 0.0 2.0 2 0 0 2 2 2 0 NACHT domain Sigma54_activ_2 PF14532.6 CCF42835.1 - 0.044 13.9 0.0 8.2 6.6 0.0 2.6 2 1 0 2 2 2 0 Sigma-54 interaction domain TsaE PF02367.17 CCF42835.1 - 0.064 13.3 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE PIF1 PF05970.14 CCF42835.1 - 0.14 11.3 0.0 0.23 10.6 0.0 1.2 1 0 0 1 1 1 0 PIF1-like helicase DUF1295 PF06966.12 CCF42836.1 - 1.7e-17 63.7 0.2 2.3e-17 63.3 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) ERG4_ERG24 PF01222.17 CCF42836.1 - 4e-08 32.5 0.6 5.8e-08 31.9 0.6 1.3 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family ICMT PF04140.14 CCF42836.1 - 0.018 15.4 0.0 0.034 14.6 0.0 1.5 1 0 0 1 1 1 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family EI24 PF07264.11 CCF42836.1 - 0.085 13.1 4.3 0.029 14.6 1.2 1.6 1 1 1 2 2 2 0 Etoposide-induced protein 2.4 (EI24) Steroid_dh PF02544.16 CCF42836.1 - 0.088 12.8 0.0 0.14 12.2 0.0 1.3 1 0 0 1 1 1 0 3-oxo-5-alpha-steroid 4-dehydrogenase Peptidase_M28 PF04389.17 CCF42837.1 - 5e-30 104.7 0.0 7.2e-30 104.1 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 CCF42837.1 - 2e-06 27.7 0.1 4.5e-06 26.5 0.1 1.7 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 DSPc PF00782.20 CCF42838.1 - 2.2e-08 34.0 0.0 5.3e-07 29.5 0.0 2.1 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Init_tRNA_PT PF04179.12 CCF42838.1 - 0.14 12.5 0.0 0.24 11.7 0.0 1.5 1 0 0 1 1 1 0 Rit1 DUSP-like domain End3 PF12761.7 CCF42840.1 - 1.2e-78 263.9 3.5 1.5e-78 263.5 3.5 1.2 1 0 0 1 1 1 1 Actin cytoskeleton-regulatory complex protein END3 EF-hand_4 PF12763.7 CCF42840.1 - 2.8e-48 162.2 0.0 2.5e-47 159.1 0.0 2.2 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 CCF42840.1 - 3.5e-07 29.3 0.2 8.4e-07 28.1 0.2 1.7 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 CCF42840.1 - 2.7e-05 24.5 0.0 9.1e-05 22.8 0.0 2.0 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 CCF42840.1 - 0.00081 19.2 0.1 0.0016 18.2 0.1 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 CCF42840.1 - 0.00087 19.0 0.2 0.0028 17.5 0.2 1.9 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.6 CCF42840.1 - 0.017 14.6 0.1 0.061 12.8 0.1 1.9 1 0 0 1 1 1 0 EF hand MDMPI_N PF11716.8 CCF42840.1 - 0.02 15.6 0.1 0.12 13.1 0.0 2.2 2 0 0 2 2 2 0 Mycothiol maleylpyruvate isomerase N-terminal domain Pyr_redox_2 PF07992.14 CCF42841.1 - 4.5e-39 134.4 0.3 5.6e-39 134.1 0.3 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCF42841.1 - 1.3e-07 32.0 0.6 7.4e-07 29.7 0.4 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCF42841.1 - 0.00053 20.2 0.0 1.1 9.6 0.0 2.5 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 CCF42841.1 - 0.00097 19.2 0.0 2.5 8.1 0.0 3.5 3 1 1 4 4 4 2 FAD-NAD(P)-binding HI0933_like PF03486.14 CCF42841.1 - 0.019 13.7 0.1 0.24 10.0 0.0 2.7 3 1 1 4 4 4 0 HI0933-like protein Thi4 PF01946.17 CCF42841.1 - 0.022 14.0 0.2 0.58 9.4 0.1 2.4 2 0 0 2 2 2 0 Thi4 family Pyr_redox_3 PF13738.6 CCF42841.1 - 0.044 13.0 0.0 0.063 12.5 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 CCF42841.1 - 0.14 11.2 0.1 18 4.3 0.0 2.6 2 1 1 3 3 3 0 Lycopene cyclase protein ACBP PF00887.19 CCF42842.1 - 3.6e-23 81.6 0.3 4.3e-23 81.3 0.3 1.1 1 0 0 1 1 1 1 Acyl CoA binding protein Tyr-DNA_phospho PF06087.12 CCF42843.1 - 1.5e-164 547.9 0.0 1.8e-164 547.7 0.0 1.0 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase PLDc_2 PF13091.6 CCF42843.1 - 0.011 15.6 0.2 0.34 10.8 0.0 2.3 2 0 0 2 2 2 0 PLD-like domain PLDc PF00614.22 CCF42843.1 - 0.2 11.9 0.3 3.8 7.8 0.4 2.7 2 0 0 2 2 2 0 Phospholipase D Active site motif WD40 PF00400.32 CCF42845.1 - 1.6e-05 25.6 0.5 0.21 12.5 0.0 2.8 2 0 0 2 2 2 2 WD domain, G-beta repeat PD40 PF07676.12 CCF42845.1 - 0.16 11.9 0.0 19 5.3 0.0 2.4 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat CAP PF00188.26 CCF42846.1 - 8.1e-19 68.7 0.6 1.2e-18 68.1 0.6 1.2 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Nop PF01798.18 CCF42847.1 - 2.1e-82 276.1 0.1 4.2e-82 275.1 0.1 1.5 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 CCF42847.1 - 5.7e-17 61.9 0.0 5.7e-17 61.9 0.0 2.5 3 0 0 3 3 3 1 NOP5NT (NUC127) domain RNA_polI_A34 PF08208.11 CCF42847.1 - 0.16 12.0 25.8 0.27 11.3 25.8 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 THOC2_N PF16134.5 CCF42847.1 - 2.3 6.7 8.0 3.6 6.1 8.0 1.2 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus CDC45 PF02724.14 CCF42848.1 - 0.017 13.5 6.8 0.022 13.1 6.8 1.4 1 0 0 1 1 1 0 CDC45-like protein DNA_pol3_a_NII PF11490.8 CCF42848.1 - 1.9 8.4 11.0 5.5 6.9 11.0 1.7 1 0 0 1 1 1 0 DNA polymerase III polC-type N-terminus II SAPS PF04499.15 CCF42848.1 - 2 7.1 13.1 4 6.1 13.1 1.5 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein MFS_1 PF07690.16 CCF42850.1 - 8.9e-38 130.1 19.5 8.9e-38 130.1 19.5 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Phage_holin_3_1 PF05106.12 CCF42850.1 - 0.076 13.4 2.6 0.34 11.4 0.5 2.9 2 0 0 2 2 2 0 Phage holin family (Lysis protein S) APS_kinase PF01583.20 CCF42851.1 - 0.0025 17.7 0.0 0.0041 17.0 0.0 1.3 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_33 PF13671.6 CCF42851.1 - 0.011 15.9 0.0 0.02 15.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 CCF42851.1 - 0.021 15.2 0.1 0.034 14.5 0.1 1.6 1 1 0 1 1 1 0 AAA ATPase domain Torsin PF06309.11 CCF42851.1 - 0.03 14.4 0.0 0.064 13.4 0.0 1.4 1 0 0 1 1 1 0 Torsin Zeta_toxin PF06414.12 CCF42851.1 - 0.038 13.3 0.0 0.069 12.4 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_18 PF13238.6 CCF42851.1 - 0.081 13.5 0.0 0.16 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain MeaB PF03308.16 CCF42851.1 - 0.16 10.9 0.0 0.24 10.4 0.0 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Iso_dh PF00180.20 CCF42852.1 - 2.8e-35 122.1 0.0 3.1e-35 122.0 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Ank_2 PF12796.7 CCF42853.1 - 1e-27 96.5 0.0 1.4e-12 48.0 0.0 3.6 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CCF42853.1 - 4.5e-24 84.5 0.7 6.7e-10 39.3 0.0 5.0 3 1 2 5 5 5 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 CCF42853.1 - 5.5e-24 83.9 0.6 2.7e-06 27.5 0.0 5.9 3 1 3 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCF42853.1 - 1.3e-21 74.3 0.7 8e-06 25.8 0.0 7.0 7 0 0 7 7 7 3 Ankyrin repeat Ank PF00023.30 CCF42853.1 - 1.5e-21 75.8 2.6 4.7e-05 23.7 0.0 7.3 7 1 0 7 7 7 5 Ankyrin repeat Ank_2 PF12796.7 CCF42854.1 - 2.2e-18 66.6 0.0 7.9e-09 36.0 0.0 4.6 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CCF42854.1 - 1.9e-14 53.8 0.3 0.043 14.4 0.0 5.5 4 2 1 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCF42854.1 - 2.3e-14 52.0 0.3 0.054 14.1 0.0 7.6 8 0 0 8 8 7 3 Ankyrin repeat Ank PF00023.30 CCF42854.1 - 1.5e-12 47.3 0.6 0.044 14.3 0.0 7.2 7 0 0 7 7 7 2 Ankyrin repeat Ank_5 PF13857.6 CCF42854.1 - 6e-06 26.4 0.8 0.53 10.7 0.0 4.9 4 1 1 5 5 5 2 Ankyrin repeats (many copies) NACHT PF05729.12 CCF42854.1 - 0.00051 20.0 0.0 0.0019 18.1 0.0 1.9 1 1 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 CCF42854.1 - 0.0038 17.5 0.0 0.011 16.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 CCF42854.1 - 0.0056 17.1 0.0 0.022 15.2 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CCF42854.1 - 0.053 13.9 0.0 0.29 11.5 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain AAA_19 PF13245.6 CCF42854.1 - 0.17 12.3 0.0 1.5 9.1 0.0 2.5 2 1 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 CCF42854.1 - 0.19 12.1 0.0 0.53 10.7 0.0 1.8 1 0 0 1 1 1 0 RNA helicase XPG_N PF00752.17 CCF42855.1 - 1.2e-31 109.1 0.0 3.4e-31 107.7 0.0 1.8 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 CCF42855.1 - 1.4e-30 105.5 1.4 2e-30 105.0 0.0 2.0 2 0 0 2 2 2 1 XPG I-region 5_3_exonuc PF01367.20 CCF42855.1 - 1.4e-05 25.6 0.2 9.8e-05 22.9 0.0 2.4 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold HHH_2 PF12826.7 CCF42855.1 - 0.059 13.5 0.0 0.19 11.8 0.0 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix motif Cyt-b5 PF00173.28 CCF42856.1 - 3.9e-21 75.0 0.3 6.7e-21 74.2 0.3 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Acyl-CoA_dh_M PF02770.19 CCF42856.1 - 9.9e-21 73.8 0.1 1.5e-20 73.1 0.1 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 CCF42856.1 - 2.6e-18 66.7 0.0 4.6e-18 65.9 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Ribosomal_60s PF00428.19 CCF42856.1 - 0.15 12.7 1.9 0.3 11.7 1.9 1.4 1 0 0 1 1 1 0 60s Acidic ribosomal protein Rad60-SLD_2 PF13881.6 CCF42857.1 - 1e-11 44.9 0.0 2.4e-11 43.7 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 CCF42857.1 - 0.00019 21.1 0.0 0.00033 20.3 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family DUF2407 PF10302.9 CCF42857.1 - 0.00098 19.7 0.0 0.0028 18.2 0.0 1.7 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain DUF2890 PF11081.8 CCF42857.1 - 0.35 11.0 6.4 0.6 10.2 6.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) Dicty_REP PF05086.12 CCF42857.1 - 6.5 4.6 7.2 8.2 4.3 7.2 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein CBFD_NFYB_HMF PF00808.23 CCF42858.1 - 4.9e-11 42.7 0.1 9e-11 41.9 0.1 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 CCF42858.1 - 1.5e-05 25.4 0.3 1.5e-05 25.4 0.3 2.2 2 1 0 2 2 2 1 Core histone H2A/H2B/H3/H4 Paf1 PF03985.13 CCF42858.1 - 0.0029 16.7 9.9 0.0044 16.1 9.9 1.2 1 0 0 1 1 1 1 Paf1 CENP-T_C PF15511.6 CCF42858.1 - 0.019 15.1 0.0 0.036 14.2 0.0 1.4 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold TFIIA PF03153.13 CCF42858.1 - 0.024 14.7 20.3 0.03 14.3 20.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit TAFII28 PF04719.14 CCF42858.1 - 0.046 13.8 0.0 0.081 13.0 0.0 1.4 1 0 0 1 1 1 0 hTAFII28-like protein conserved region Cwf_Cwc_15 PF04889.12 CCF42858.1 - 3.3 7.4 22.0 0.93 9.2 19.1 1.7 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Hamartin PF04388.12 CCF42858.1 - 5.5 5.5 14.6 7.7 5.0 14.6 1.2 1 0 0 1 1 1 0 Hamartin protein Nop14 PF04147.12 CCF42858.1 - 7.2 4.7 27.1 10 4.2 27.1 1.3 1 0 0 1 1 1 0 Nop14-like family Peptidase_S24 PF00717.23 CCF42859.1 - 0.00033 20.6 0.1 0.00096 19.1 0.1 1.8 1 1 0 1 1 1 1 Peptidase S24-like Stm1_N PF09598.10 CCF42861.1 - 4.1e-11 43.5 6.0 4.1e-11 43.5 6.0 3.4 3 1 0 3 3 3 1 Stm1 HABP4_PAI-RBP1 PF04774.15 CCF42861.1 - 0.014 16.3 8.4 0.014 16.3 8.4 2.8 2 2 2 4 4 4 0 Hyaluronan / mRNA binding family HemX PF04375.14 CCF42861.1 - 0.077 12.3 3.2 0.11 11.8 3.2 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Prefoldin_2 PF01920.20 CCF42862.1 - 0.0076 16.2 2.5 0.011 15.7 2.5 1.2 1 0 0 1 1 1 1 Prefoldin subunit DUF2205 PF10224.9 CCF42862.1 - 0.01 15.8 1.3 0.01 15.8 1.3 1.1 1 0 0 1 1 1 0 Short coiled-coil protein Cmc1 PF08583.10 CCF42863.1 - 1.5e-15 56.9 2.0 1.8e-15 56.7 2.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like Tmemb_14 PF03647.13 CCF42864.1 - 8e-24 84.2 6.8 9.1e-24 84.0 6.8 1.0 1 0 0 1 1 1 1 Transmembrane proteins 14C DAD PF02109.16 CCF42865.1 - 4.2e-14 52.8 0.2 5.3e-14 52.5 0.2 1.1 1 0 0 1 1 1 1 DAD family DUF1180 PF06679.12 CCF42865.1 - 0.036 14.5 1.1 0.042 14.3 1.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) YkpC PF17447.2 CCF42865.1 - 0.2 12.5 1.7 0.46 11.4 0.8 2.2 2 0 0 2 2 2 0 Uncharacterized YkpC-like NmrA PF05368.13 CCF42866.1 - 8e-35 120.5 0.4 1.1e-34 120.0 0.4 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CCF42866.1 - 1.8e-05 24.7 0.4 0.003 17.5 0.5 2.4 2 1 0 2 2 2 1 NAD(P)H-binding adh_short_C2 PF13561.6 CCF42867.1 - 2.5e-30 105.8 0.1 4.8e-30 104.9 0.1 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF42867.1 - 3.6e-25 88.6 0.0 5.7e-25 87.9 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF42867.1 - 2.9e-06 27.3 0.0 4.3e-06 26.8 0.0 1.4 1 1 0 1 1 1 1 KR domain THF_DHG_CYH_C PF02882.19 CCF42867.1 - 0.00034 20.0 0.0 0.00095 18.5 0.0 1.6 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Epimerase PF01370.21 CCF42867.1 - 0.061 12.8 0.1 0.21 11.0 0.1 1.8 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 CCF42867.1 - 0.073 12.1 0.3 0.16 11.1 0.1 1.8 2 1 0 2 2 2 0 RmlD substrate binding domain DUF5305 PF17231.2 CCF42868.1 - 0.028 13.8 6.3 5.5 6.3 5.6 2.4 2 1 0 2 2 2 0 Family of unknown function (DUF5305) DUF1780 PF08682.10 CCF42868.1 - 0.082 12.6 0.1 1.9 8.1 0.0 2.2 1 1 1 2 2 2 0 Putative endonuclease, protein of unknown function (DUF1780) P5CR_dimer PF14748.6 CCF42868.1 - 0.12 12.6 1.6 1.8 8.8 0.0 2.4 1 1 1 2 2 2 0 Pyrroline-5-carboxylate reductase dimerisation zf-CCHC PF00098.23 CCF42868.1 - 2 8.7 7.3 1 9.6 3.9 2.3 2 0 0 2 2 2 0 Zinc knuckle RRM_1 PF00076.22 CCF42869.1 - 4.7e-15 55.2 0.0 9e-14 51.0 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CCF42869.1 - 0.0025 17.9 0.0 0.0062 16.6 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif WD40 PF00400.32 CCF42870.1 - 0.00014 22.6 0.0 1.9 9.5 0.0 3.1 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF42870.1 - 0.056 13.7 0.0 0.27 11.6 0.0 2.1 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CCF42870.1 - 0.061 12.3 0.0 2.3 7.1 0.0 2.2 1 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein TRAM_LAG1_CLN8 PF03798.16 CCF42871.1 - 5.7e-37 127.4 18.8 8.4e-37 126.8 18.8 1.2 1 0 0 1 1 1 1 TLC domain TRAM1 PF08390.11 CCF42871.1 - 8.4e-26 89.4 1.6 2.5e-25 87.9 0.0 2.3 2 0 0 2 2 2 1 TRAM1-like protein ABC_tran PF00005.27 CCF42872.1 - 3.9e-32 111.6 0.1 1.9e-31 109.4 0.0 2.1 2 0 0 2 2 2 1 ABC transporter ABC_membrane PF00664.23 CCF42872.1 - 9.6e-29 100.9 9.7 9.6e-29 100.9 9.7 2.2 3 0 0 3 3 3 1 ABC transporter transmembrane region SMC_N PF02463.19 CCF42872.1 - 5.6e-06 25.9 0.1 5.1e-05 22.8 0.0 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 CCF42872.1 - 0.012 15.5 0.0 0.032 14.1 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase AAA_29 PF13555.6 CCF42872.1 - 0.053 13.3 0.1 0.23 11.3 0.1 2.1 2 0 0 2 2 2 0 P-loop containing region of AAA domain Big_2 PF02368.18 CCF42872.1 - 0.098 12.6 0.0 0.31 11.0 0.0 1.8 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 2) DAD PF02109.16 CCF42872.1 - 0.19 12.1 3.4 0.43 10.9 0.2 3.1 3 1 1 4 4 4 0 DAD family DUF202 PF02656.15 CCF42872.1 - 0.23 12.0 3.9 0.98 9.9 1.6 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF202) HLH PF00010.26 CCF42874.1 - 3.8e-13 49.2 0.1 1e-12 47.8 0.0 1.8 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain MFAP1 PF06991.11 CCF42874.1 - 1.3 8.8 12.4 0.039 13.8 4.7 1.9 2 0 0 2 2 2 0 Microfibril-associated/Pre-mRNA processing Ric8 PF10165.9 CCF42875.1 - 6.2e-131 437.6 0.1 7.1e-131 437.4 0.1 1.0 1 0 0 1 1 1 1 Guanine nucleotide exchange factor synembryn Fungal_trans PF04082.18 CCF42876.1 - 4.7e-21 75.0 0.2 1.1e-20 73.7 0.2 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF42876.1 - 0.0015 18.6 6.4 0.0028 17.7 6.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Amidohydro_3 PF07969.11 CCF42877.1 - 5.4e-51 174.5 0.3 6.9e-51 174.2 0.3 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_1 PF01979.20 CCF42877.1 - 0.0045 16.4 0.4 0.058 12.7 0.0 2.3 2 1 0 2 2 2 1 Amidohydrolase family DUF917 PF06032.12 CCF42878.1 - 7e-50 169.8 0.0 7.9e-50 169.6 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF917) TMEM154 PF15102.6 CCF42880.1 - 0.0025 17.7 0.0 0.0072 16.2 0.0 1.9 1 1 0 1 1 1 1 TMEM154 protein family Trp_oprn_chp PF09534.10 CCF42880.1 - 0.02 14.7 0.0 0.025 14.4 0.0 1.1 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Syndecan PF01034.20 CCF42880.1 - 0.091 12.7 0.0 0.24 11.3 0.0 1.6 2 0 0 2 2 2 0 Syndecan domain DUF4381 PF14316.6 CCF42880.1 - 0.11 12.7 0.6 0.19 11.9 0.6 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4381) Flu_M2 PF00599.17 CCF42880.1 - 0.12 12.4 0.0 0.18 11.9 0.0 1.4 1 1 0 1 1 1 0 Influenza Matrix protein (M2) DUF2207 PF09972.9 CCF42880.1 - 0.19 10.4 0.0 0.2 10.4 0.0 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) SKG6 PF08693.10 CCF42880.1 - 0.99 8.9 2.9 1.6 8.2 2.9 1.2 1 0 0 1 1 1 0 Transmembrane alpha-helix domain DUF5074 PF16819.5 CCF42882.1 - 0.067 13.2 0.3 0.075 13.1 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5074) Dioxygenase_C PF00775.21 CCF42883.1 - 6.1e-05 22.5 0.0 0.00018 21.0 0.0 1.9 1 1 0 1 1 1 1 Dioxygenase HEPN_SAV2148 PF18725.1 CCF42884.1 - 0.0093 15.4 0.1 0.0093 15.4 0.1 1.0 1 0 0 1 1 1 1 SAV2148-like HEPN DUF2681 PF10883.8 CCF42884.1 - 0.024 15.0 0.0 0.044 14.2 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2681) VSG_B PF13206.6 CCF42884.1 - 0.27 10.4 3.6 0.3 10.3 3.6 1.0 1 0 0 1 1 1 0 Trypanosomal VSG domain Cauli_VI PF01693.16 CCF42886.1 - 6.9e-28 96.7 0.7 5e-15 55.5 0.3 2.4 2 0 0 2 2 2 2 Caulimovirus viroplasmin Uma2 PF05685.12 CCF42887.1 - 0.0013 18.3 0.0 0.0028 17.2 0.0 1.4 1 1 0 1 1 1 1 Putative restriction endonuclease Glyco_hydro_61 PF03443.14 CCF42888.1 - 7.3e-11 42.4 0.2 8.2e-11 42.2 0.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 DUF3602 PF12223.8 CCF42889.1 - 8.1e-09 36.0 6.2 9.8e-05 22.9 1.8 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF3602) Tim54 PF11711.8 CCF42891.1 - 2.3 6.9 9.1 2.5 6.8 9.1 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Cupin_2 PF07883.11 CCF42894.1 - 9.3e-08 31.7 0.0 2.3e-07 30.4 0.0 1.7 1 0 0 1 1 1 1 Cupin domain FAA_hydrolase PF01557.18 CCF42896.1 - 1.2e-64 218.0 0.0 1.5e-64 217.7 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Pkinase PF00069.25 CCF42897.1 - 2.1e-14 53.5 0.0 2.1e-13 50.3 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF42897.1 - 1.3e-10 41.0 0.0 1.9e-10 40.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF42897.1 - 0.016 14.6 0.0 0.034 13.5 0.0 1.5 1 1 0 1 1 1 0 Kinase-like DUF1751 PF08551.10 CCF42899.1 - 1.2e-21 77.1 2.5 2e-21 76.4 2.5 1.4 1 0 0 1 1 1 1 Eukaryotic integral membrane protein (DUF1751) Rhomboid PF01694.22 CCF42899.1 - 0.021 14.9 1.1 0.021 14.9 1.1 1.6 2 0 0 2 2 2 0 Rhomboid family AGO_N PF18236.1 CCF42900.1 - 0.23 11.7 0.0 0.29 11.3 0.0 1.2 1 0 0 1 1 1 0 Argonaute N domain PALP PF00291.25 CCF42901.1 - 1.4e-19 70.7 0.1 3.9e-19 69.2 0.1 1.6 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Na_Ala_symp PF01235.17 CCF42901.1 - 0.14 11.4 0.0 0.2 10.9 0.0 1.1 1 0 0 1 1 1 0 Sodium:alanine symporter family TauD PF02668.16 CCF42902.1 - 1.1e-24 87.7 0.1 1.3e-24 87.4 0.1 1.0 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF5389 PF17364.2 CCF42903.1 - 0.0016 18.4 2.2 0.0042 17.1 0.1 2.5 2 0 0 2 2 2 1 Family of unknown function (DUF5389) DUF2116 PF09889.9 CCF42903.1 - 0.16 12.0 0.2 0.16 12.0 0.2 2.8 3 0 0 3 3 3 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) Ac76 PF05814.11 CCF42903.1 - 0.67 10.0 3.0 2.8 8.0 0.2 2.6 2 0 0 2 2 2 0 Orf76 (Ac76) DUF2207 PF09972.9 CCF42903.1 - 7.9 5.1 7.1 4.4 6.0 1.0 2.9 3 1 0 3 3 3 0 Predicted membrane protein (DUF2207) SNF PF00209.18 CCF42904.1 - 4.6e-89 299.5 32.1 1.8e-88 297.5 32.1 1.8 1 1 0 1 1 1 1 Sodium:neurotransmitter symporter family Fungal_trans PF04082.18 CCF42906.1 - 8e-25 87.4 0.0 1.5e-24 86.4 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain MFS_1 PF07690.16 CCF42907.1 - 0.026 13.5 8.1 0.028 13.4 7.5 1.3 1 1 0 1 1 1 0 Major Facilitator Superfamily Srg PF02118.21 CCF42907.1 - 0.1 12.2 1.6 0.12 12.0 1.6 1.0 1 0 0 1 1 1 0 Srg family chemoreceptor EF-hand_4 PF12763.7 CCF42908.1 - 1.5e-13 50.6 0.0 3.7e-13 49.3 0.0 1.6 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand CENP-F_leu_zip PF10473.9 CCF42908.1 - 6.3e-06 26.3 30.1 0.00029 20.9 10.3 3.1 1 1 2 3 3 3 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 EF-hand_7 PF13499.6 CCF42908.1 - 0.0012 19.2 0.0 0.0028 18.0 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair GAS PF13851.6 CCF42908.1 - 0.0024 17.3 31.3 0.12 11.7 15.1 2.2 1 1 1 2 2 2 2 Growth-arrest specific micro-tubule binding TMF_TATA_bd PF12325.8 CCF42908.1 - 0.003 17.7 25.9 0.016 15.4 4.0 3.3 1 1 2 3 3 3 2 TATA element modulatory factor 1 TATA binding Spc7 PF08317.11 CCF42908.1 - 0.006 15.5 29.8 0.21 10.5 15.2 2.2 1 1 1 2 2 2 2 Spc7 kinetochore protein SYCE1 PF15233.6 CCF42908.1 - 0.0061 16.6 23.9 0.0096 16.0 14.0 2.2 1 1 1 2 2 2 1 Synaptonemal complex central element protein 1 HAP1_N PF04849.13 CCF42908.1 - 0.02 14.1 26.9 0.56 9.4 16.0 2.1 1 1 1 2 2 2 0 HAP1 N-terminal conserved region GOLGA2L5 PF15070.6 CCF42908.1 - 0.027 13.2 20.2 0.041 12.6 20.2 1.2 1 0 0 1 1 1 0 Putative golgin subfamily A member 2-like protein 5 EF-hand_1 PF00036.32 CCF42908.1 - 0.036 13.6 0.0 7.5 6.4 0.0 2.5 2 0 0 2 2 2 0 EF hand PRKG1_interact PF15898.5 CCF42908.1 - 0.043 14.7 29.7 0.081 13.8 7.8 3.4 1 1 2 3 3 3 0 cGMP-dependent protein kinase interacting domain TPR_MLP1_2 PF07926.12 CCF42908.1 - 0.065 13.3 34.8 0.23 11.5 17.5 2.5 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein YkyA PF10368.9 CCF42908.1 - 0.1 12.3 24.6 0.12 12.0 3.1 2.9 2 1 0 2 2 2 0 Putative cell-wall binding lipoprotein TolA_bind_tri PF16331.5 CCF42908.1 - 0.1 12.7 34.4 0.29 11.2 10.4 4.4 1 1 3 4 4 4 0 TolA binding protein trimerisation DUF3584 PF12128.8 CCF42908.1 - 0.14 9.6 25.6 0.22 9.0 25.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) kleA_kleC PF17383.2 CCF42908.1 - 0.2 12.0 5.5 2.2 8.6 1.1 3.0 2 1 1 3 3 2 0 Uncharacterized KorC regulated protein A Fez1 PF06818.15 CCF42908.1 - 0.32 11.4 27.4 0.049 14.1 14.9 2.2 1 1 1 2 2 2 0 Fez1 DUF1664 PF07889.12 CCF42908.1 - 0.33 11.0 16.0 0.084 12.9 6.8 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) APG6_N PF17675.1 CCF42908.1 - 0.43 11.1 34.8 0.71 10.4 20.1 3.2 1 1 2 3 3 3 0 Apg6 coiled-coil region ATG16 PF08614.11 CCF42908.1 - 0.43 10.8 41.4 1.3 9.2 12.1 3.2 2 1 1 3 3 2 0 Autophagy protein 16 (ATG16) ADIP PF11559.8 CCF42908.1 - 0.44 10.6 36.4 0.18 11.9 7.5 3.3 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding Laminin_I PF06008.14 CCF42908.1 - 0.77 9.4 28.1 0.32 10.7 6.5 2.6 1 1 2 3 3 3 0 Laminin Domain I 4HB_MCP_1 PF12729.7 CCF42908.1 - 0.82 9.2 17.7 2.2 7.8 1.4 3.4 1 1 2 3 3 3 0 Four helix bundle sensory module for signal transduction TMF_DNA_bd PF12329.8 CCF42908.1 - 0.83 9.7 31.7 0.32 11.0 10.5 3.3 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding SOGA PF11365.8 CCF42908.1 - 0.84 10.8 21.9 2.2 9.4 0.7 3.1 1 1 1 3 3 3 0 Protein SOGA Myosin_tail_1 PF01576.19 CCF42908.1 - 0.93 7.2 27.7 0.57 7.9 4.5 1.9 1 1 0 1 1 1 0 Myosin tail DUF4201 PF13870.6 CCF42908.1 - 0.93 9.2 27.2 1.2 8.8 12.5 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) MscS_porin PF12795.7 CCF42908.1 - 1.5 8.3 43.1 3.4 7.1 18.9 2.3 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain FUSC PF04632.12 CCF42908.1 - 1.5 7.2 8.8 2.3 6.7 8.8 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family PI_PP_I PF18363.1 CCF42908.1 - 2.6 8.3 5.1 29 4.9 0.9 2.6 2 0 0 2 2 2 0 Phosphoinositide phosphatase insertion domain FapA PF03961.13 CCF42908.1 - 2.9 6.4 23.6 0.5 8.9 7.9 2.1 1 1 1 2 2 2 0 Flagellar Assembly Protein A DUF2730 PF10805.8 CCF42908.1 - 3.1 7.9 15.7 8.6 6.5 2.0 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF2730) Filament PF00038.21 CCF42908.1 - 3.3 7.2 28.0 2.8e+02 0.9 28.0 2.5 1 1 0 1 1 1 0 Intermediate filament protein DUF4618 PF15397.6 CCF42908.1 - 3.6 6.9 22.7 1e+02 2.2 19.0 3.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4618) DHR10 PF18595.1 CCF42908.1 - 3.7 7.6 33.9 4.7 7.3 14.6 3.5 1 1 2 3 3 3 0 Designed helical repeat protein 10 domain HMMR_N PF15905.5 CCF42908.1 - 4 6.8 27.3 7.2 6.0 27.3 1.4 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Jnk-SapK_ap_N PF09744.9 CCF42908.1 - 4.1 7.6 30.3 5.3 7.3 14.2 2.3 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 Golgin_A5 PF09787.9 CCF42908.1 - 4.4 6.7 30.0 2.6 7.4 21.4 2.1 1 1 1 2 2 2 0 Golgin subfamily A member 5 MbeD_MobD PF04899.12 CCF42908.1 - 4.5 7.5 21.7 1.4 9.1 1.0 4.4 2 1 2 4 4 4 0 MbeD/MobD like DUF724 PF05266.14 CCF42908.1 - 4.6 7.0 23.0 0.31 10.8 6.6 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF724) COG2 PF06148.11 CCF42908.1 - 4.8 7.3 15.4 0.54 10.3 5.2 2.5 1 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF3450 PF11932.8 CCF42908.1 - 5.7 6.2 32.3 3.2 7.0 14.7 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) AvrLm4-7 PF18661.1 CCF42908.1 - 6 8.0 8.0 2.7 9.1 1.0 3.0 1 1 2 3 3 3 0 Avirulence Effector AvrLm4-7 FlaC_arch PF05377.11 CCF42908.1 - 7.1 7.1 17.1 11 6.5 1.0 4.5 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) Fib_alpha PF08702.10 CCF42908.1 - 8.7 6.5 22.8 0.64 10.2 9.7 2.8 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family FPP PF05911.11 CCF42908.1 - 9.7 4.2 30.7 5.9 5.0 8.5 2.1 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil PMC2NT PF08066.12 CCF42911.1 - 1.2e-24 86.8 0.5 2e-24 86.1 0.5 1.3 1 0 0 1 1 1 1 PMC2NT (NUC016) domain NAD_binding_6 PF08030.12 CCF42912.1 - 1.1e-16 61.4 0.0 1.5e-16 60.9 0.0 1.2 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 CCF42912.1 - 9.3e-12 45.2 12.5 9.3e-12 45.2 12.5 2.6 2 0 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 CCF42912.1 - 2.2e-08 34.1 0.0 5.2e-08 33.0 0.0 1.5 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_1 PF00175.21 CCF42912.1 - 0.022 15.4 0.0 6 7.6 0.0 2.7 3 0 0 3 3 3 0 Oxidoreductase NAD-binding domain S19 PF06756.11 CCF42912.1 - 0.069 13.1 0.0 0.18 11.8 0.0 1.7 1 0 0 1 1 1 0 Chorion protein S19 C-terminal DsrC PF04358.13 CCF42913.1 - 0.052 14.1 0.0 0.062 13.8 0.0 1.2 1 0 0 1 1 1 0 DsrC like protein CDC14 PF08045.11 CCF42914.1 - 1.3e-124 415.0 0.1 1.4e-124 414.8 0.1 1.0 1 0 0 1 1 1 1 Cell division control protein 14, SIN component Methyltransf_12 PF08242.12 CCF42916.1 - 6.2e-20 71.8 0.0 1.5e-19 70.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF42916.1 - 5.7e-11 43.0 0.0 1.9e-10 41.3 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF42916.1 - 8.4e-11 42.4 0.0 7.5e-10 39.3 0.0 2.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF42916.1 - 2.1e-09 37.3 0.0 4.2e-09 36.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PS-DH PF14765.6 CCF42916.1 - 7.7e-09 35.2 0.0 1.3e-08 34.4 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase Methyltransf_23 PF13489.6 CCF42916.1 - 4.1e-08 33.2 0.0 7.9e-08 32.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCF42916.1 - 2e-06 27.3 0.0 4.3e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family ADH_N PF08240.12 CCF42916.1 - 4.7e-05 23.2 0.1 0.00011 22.1 0.1 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCF42916.1 - 0.00017 21.6 0.0 0.0013 18.7 0.0 2.2 2 0 0 2 2 2 1 Zinc-binding dehydrogenase PCMT PF01135.19 CCF42916.1 - 0.066 13.0 0.2 0.3 10.8 0.0 2.1 2 0 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_24 PF13578.6 CCF42916.1 - 0.072 14.1 0.0 1.5 9.8 0.0 2.6 2 0 0 2 2 2 0 Methyltransferase domain MTS PF05175.14 CCF42916.1 - 0.15 11.6 0.0 0.36 10.4 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase small domain DUF938 PF06080.12 CCF42916.1 - 0.17 11.6 0.0 1.1 9.0 0.0 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF938) ATP-synt_J PF04911.12 CCF42917.1 - 3.7e-26 90.5 1.1 4.1e-26 90.3 1.1 1.0 1 0 0 1 1 1 1 ATP synthase j chain APH PF01636.23 CCF42919.1 - 7.8e-15 55.4 0.1 1.3e-14 54.8 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family AA_permease_2 PF13520.6 CCF42920.1 - 8.6e-19 67.7 7.5 9.9e-19 67.5 7.5 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CCF42920.1 - 5e-08 32.0 7.5 6.2e-08 31.7 7.5 1.0 1 0 0 1 1 1 1 Amino acid permease Peptidase_C14 PF00656.22 CCF42922.1 - 0.0084 16.1 0.0 0.016 15.2 0.0 1.5 1 0 0 1 1 1 1 Caspase domain Raptor_N PF14538.6 CCF42922.1 - 0.009 16.0 0.1 0.028 14.4 0.0 1.8 2 0 0 2 2 2 1 Raptor N-terminal CASPase like domain Pneumo_att_G PF05539.11 CCF42922.1 - 0.025 14.2 7.9 0.042 13.5 7.9 1.2 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G zf-C2H2_4 PF13894.6 CCF42922.1 - 0.027 15.3 19.0 0.095 13.6 0.8 4.9 4 1 0 4 4 4 0 C2H2-type zinc finger zf-C2H2 PF00096.26 CCF42922.1 - 0.067 13.7 21.7 0.12 12.9 0.7 4.4 4 1 0 4 4 4 0 Zinc finger, C2H2 type zf-TRAF PF02176.18 CCF42922.1 - 0.079 13.7 0.6 0.29 11.9 0.6 2.1 1 0 0 1 1 1 0 TRAF-type zinc finger Sina PF03145.16 CCF42922.1 - 0.11 12.4 2.9 0.24 11.3 2.9 1.5 1 0 0 1 1 1 0 Seven in absentia protein family zf-C2H2_jaz PF12171.8 CCF42922.1 - 0.13 12.6 2.0 6.3 7.2 0.1 2.8 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Glyco_hydro_43 PF04616.14 CCF42923.1 - 9.7e-20 71.0 1.1 1.6e-19 70.3 1.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 Glyco_hydro_31 PF01055.26 CCF42924.1 - 5.9e-155 516.8 1.6 7.5e-155 516.4 1.6 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 CCF42924.1 - 6e-40 136.1 0.0 1.1e-39 135.3 0.0 1.4 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Gal_mutarotas_2 PF13802.6 CCF42924.1 - 7.7e-15 55.0 1.4 7.7e-15 55.0 1.4 2.5 2 0 0 2 2 2 1 Galactose mutarotase-like Glyco_hydro_28 PF00295.17 CCF42925.1 - 1e-51 175.9 11.3 1.5e-51 175.4 11.3 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 adh_short PF00106.25 CCF42926.1 - 2.6e-21 76.0 0.1 5.5e-21 74.9 0.1 1.5 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF42926.1 - 4.5e-16 59.1 0.5 7.5e-16 58.4 0.5 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF42926.1 - 2.6e-08 34.0 0.6 4.5e-08 33.2 0.6 1.4 1 1 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 CCF42926.1 - 0.00014 21.8 0.7 0.00018 21.4 0.7 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CCF42926.1 - 0.0004 19.9 0.0 0.00091 18.8 0.0 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family RNA_pol_Rpb2_45 PF10385.9 CCF42927.1 - 0.13 12.6 0.1 0.22 11.8 0.1 1.6 1 0 0 1 1 1 0 RNA polymerase beta subunit external 1 domain ADH_zinc_N_2 PF13602.6 CCF42928.1 - 3.5e-26 92.8 0.1 4.1e-26 92.6 0.1 1.0 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 CCF42928.1 - 3.8e-11 43.1 0.0 4.9e-11 42.7 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase FAD-oxidase_C PF02913.19 CCF42929.1 - 3.9e-08 33.2 0.1 6.3e-08 32.5 0.1 1.3 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain TauD PF02668.16 CCF42930.1 - 1.3e-31 110.3 1.1 2e-31 109.8 0.8 1.4 1 1 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family CsiD PF08943.10 CCF42930.1 - 0.17 11.0 0.0 0.28 10.2 0.0 1.3 1 0 0 1 1 1 0 CsiD HsbA PF12296.8 CCF42931.1 - 1.9e-21 76.7 2.5 1.9e-21 76.7 2.5 2.2 3 0 0 3 3 3 1 Hydrophobic surface binding protein A Glyco_hydro_16 PF00722.21 CCF42934.1 - 0.00052 19.5 0.3 0.02 14.4 0.3 2.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 16 ABC_tran PF00005.27 CCF42935.1 - 7.9e-32 110.6 0.0 1.5e-31 109.7 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 CCF42935.1 - 2.7e-15 56.8 5.0 3.4e-15 56.4 5.0 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 CCF42935.1 - 1.1e-06 28.3 0.0 1.4e-05 24.7 0.0 2.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 CCF42935.1 - 0.00048 20.6 0.2 0.0012 19.3 0.2 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 CCF42935.1 - 0.0016 18.7 0.0 0.015 15.6 0.0 2.3 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 CCF42935.1 - 0.0061 16.5 0.0 0.012 15.5 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase DUF87 PF01935.17 CCF42935.1 - 0.019 15.1 0.0 0.045 13.9 0.0 1.5 1 0 0 1 1 1 0 Helicase HerA, central domain AAA_10 PF12846.7 CCF42935.1 - 0.019 13.9 0.0 0.038 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA-like domain AAA_15 PF13175.6 CCF42935.1 - 0.026 14.2 0.0 0.04 13.6 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain AAA_21 PF13304.6 CCF42935.1 - 0.042 13.6 0.1 0.36 10.6 0.0 2.2 1 1 1 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system DUF815 PF05673.13 CCF42935.1 - 0.046 12.9 0.0 0.084 12.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA PF00004.29 CCF42935.1 - 0.059 13.8 0.0 0.71 10.3 0.0 2.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 CCF42935.1 - 0.081 12.2 0.0 0.17 11.1 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_30 PF13604.6 CCF42935.1 - 0.083 12.6 0.0 0.26 11.0 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 CCF42935.1 - 0.088 12.6 0.2 0.26 11.1 0.2 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 CCF42935.1 - 0.11 12.5 0.0 0.25 11.4 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase TsaE PF02367.17 CCF42935.1 - 0.16 12.0 0.0 0.37 10.8 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE hnRNP_Q_AcD PF18360.1 CCF42936.1 - 0.038 13.9 0.6 0.038 13.9 0.6 3.4 4 1 0 4 4 4 0 Heterogeneous nuclear ribonucleoprotein Q acidic domain Ribosomal_L44 PF00935.19 CCF42937.1 - 1.1e-36 125.1 12.5 1.6e-36 124.6 12.5 1.3 1 0 0 1 1 1 1 Ribosomal protein L44 Sugar_tr PF00083.24 CCF42938.1 - 3.5e-53 181.1 6.8 4.6e-53 180.7 6.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF42938.1 - 2.6e-17 62.8 9.8 3.1e-17 62.6 9.8 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 CCF42938.1 - 0.00076 18.0 0.9 0.00089 17.8 0.9 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) AA_permease PF00324.21 CCF42939.1 - 0.0022 16.6 0.4 0.0026 16.4 0.4 1.0 1 0 0 1 1 1 1 Amino acid permease DUF1198 PF06711.11 CCF42939.1 - 0.065 13.3 0.0 0.07 13.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1198) FAD_binding_3 PF01494.19 CCF42940.1 - 1.2e-87 294.4 0.0 1.9e-87 293.8 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.12 CCF42940.1 - 2.3e-56 190.4 0.0 4.1e-56 189.6 0.0 1.4 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain HI0933_like PF03486.14 CCF42940.1 - 9.4e-05 21.3 0.2 0.00014 20.7 0.2 1.2 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_2 PF00890.24 CCF42940.1 - 0.00023 20.4 0.2 0.00038 19.7 0.2 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 CCF42940.1 - 0.0043 17.3 0.1 0.02 15.1 0.1 2.2 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 CCF42940.1 - 0.0044 16.3 0.0 0.009 15.3 0.0 1.4 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.14 CCF42940.1 - 0.02 14.1 0.1 0.049 12.8 0.1 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCF42940.1 - 0.027 13.7 0.1 0.04 13.2 0.1 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 CCF42940.1 - 0.035 13.5 0.2 0.058 12.7 0.2 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 CCF42940.1 - 0.061 12.6 0.0 0.099 11.9 0.0 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 CCF42940.1 - 0.072 12.2 0.3 0.11 11.5 0.3 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A Pyr_redox PF00070.27 CCF42940.1 - 0.16 12.5 0.0 0.37 11.4 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase ERG4_ERG24 PF01222.17 CCF42941.1 - 1.1e-167 558.2 0.4 1.2e-167 558.0 0.4 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 CCF42941.1 - 0.00028 20.5 0.1 0.00092 18.8 0.1 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) PolyA_pol PF01743.20 CCF42942.1 - 2.8e-07 31.0 0.0 4.4e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 Poly A polymerase head domain BP28CT PF08146.12 CCF42943.1 - 3.2e-44 150.5 1.0 3.2e-44 150.5 1.0 2.3 3 0 0 3 3 3 1 BP28CT (NUC211) domain HEAT PF02985.22 CCF42943.1 - 6.1e-06 26.1 5.1 0.059 13.7 0.1 5.6 5 0 0 5 5 5 2 HEAT repeat RTP1_C1 PF10363.9 CCF42943.1 - 0.033 14.4 0.7 1.1 9.4 0.1 3.2 2 1 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 Hemerythrin PF01814.23 CCF42944.1 - 2.5e-09 37.9 1.1 3.4e-09 37.4 1.1 1.2 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain EF-hand_7 PF13499.6 CCF42945.1 - 1.7e-25 89.3 8.9 1.4e-16 60.7 1.2 3.0 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 CCF42945.1 - 6.8e-25 84.8 4.9 3.8e-06 26.4 0.1 5.2 5 0 0 5 5 5 4 EF-hand domain EF-hand_1 PF00036.32 CCF42945.1 - 2.8e-24 82.8 13.8 3.2e-08 32.5 0.2 4.8 5 0 0 5 5 5 3 EF hand EF-hand_5 PF13202.6 CCF42945.1 - 2.5e-17 61.5 13.8 3.8e-05 23.0 0.1 4.6 5 0 0 5 5 5 4 EF hand EF-hand_8 PF13833.6 CCF42945.1 - 6.8e-15 54.7 12.2 3e-05 23.8 1.0 3.9 2 2 1 3 3 3 3 EF-hand domain pair EF-hand_4 PF12763.7 CCF42945.1 - 4.1e-09 36.3 8.1 0.0046 16.9 0.2 4.0 1 1 2 4 4 4 3 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 CCF42945.1 - 8.3e-05 22.8 0.6 0.0086 16.4 0.1 2.9 2 1 1 3 3 3 2 EF-hand domain SPARC_Ca_bdg PF10591.9 CCF42945.1 - 0.00097 19.4 3.4 0.96 9.8 0.4 3.1 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region DUF1679 PF07914.11 CCF42945.1 - 0.027 13.4 0.4 2.1 7.1 0.1 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF1679) EF-hand_10 PF14788.6 CCF42945.1 - 0.08 12.8 5.1 0.27 11.1 0.0 3.6 5 0 0 5 5 5 0 EF hand Staphylokinase PF02821.16 CCF42945.1 - 0.085 13.3 0.0 5.4 7.5 0.0 2.5 1 1 0 1 1 1 0 Staphylokinase/Streptokinase family EF-hand_14 PF17959.1 CCF42945.1 - 0.12 12.7 2.9 6.8 7.1 0.0 3.6 3 1 0 3 3 3 0 EF-hand domain AMP-binding PF00501.28 CCF42946.1 - 6e-90 301.8 0.0 9.4e-90 301.2 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme CdhD PF03599.16 CCF42946.1 - 0.0034 16.2 0.0 0.0056 15.5 0.0 1.2 1 0 0 1 1 1 1 CO dehydrogenase/acetyl-CoA synthase delta subunit AMP-binding_C PF13193.6 CCF42946.1 - 0.018 16.0 0.3 0.053 14.5 0.3 1.9 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain 5-FTHF_cyc-lig PF01812.20 CCF42947.1 - 5.4e-28 98.1 0.0 6.8e-28 97.8 0.0 1.1 1 0 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family SBDS_C PF09377.10 CCF42947.1 - 0.011 15.7 0.0 0.015 15.3 0.0 1.2 1 0 0 1 1 1 0 SBDS protein C-terminal domain LSM PF01423.22 CCF42948.1 - 2.6e-15 55.8 0.4 3.1e-15 55.6 0.4 1.1 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 CCF42948.1 - 0.0018 17.9 0.2 0.0028 17.3 0.2 1.3 1 0 0 1 1 1 1 Hfq protein PhnA PF03831.14 CCF42948.1 - 0.081 12.8 0.1 2.2 8.2 0.0 2.2 2 0 0 2 2 2 0 PhnA domain CLP1_N PF16573.5 CCF42950.1 - 8.9e-29 99.6 0.0 1.1e-28 99.2 0.0 1.1 1 0 0 1 1 1 1 N-terminal beta-sandwich domain of polyadenylation factor CLP1_P PF16575.5 CCF42950.1 - 9.3e-06 25.6 0.0 1.4e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop ATP_bind_1 PF03029.17 CCF42950.1 - 0.00022 21.1 0.0 0.00031 20.6 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_28 PF13521.6 CCF42950.1 - 0.00085 19.6 0.9 0.001 19.3 0.1 1.5 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 CCF42950.1 - 0.0012 18.7 0.0 0.0016 18.2 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CCF42950.1 - 0.0012 19.2 0.1 0.0022 18.4 0.1 1.4 1 1 0 1 1 1 1 AAA ATPase domain MMR_HSR1 PF01926.23 CCF42950.1 - 0.0018 18.4 0.0 0.003 17.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_35 PF14516.6 CCF42950.1 - 0.0035 16.2 0.0 0.0048 15.8 0.0 1.2 1 0 0 1 1 1 1 AAA-like domain FeoB_N PF02421.18 CCF42950.1 - 0.0076 15.8 0.0 0.013 15.0 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B AAA_22 PF13401.6 CCF42950.1 - 0.041 14.1 0.0 0.067 13.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain KTI12 PF08433.10 CCF42950.1 - 0.048 13.1 0.0 0.07 12.6 0.0 1.2 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_19 PF13245.6 CCF42950.1 - 0.055 13.8 0.0 0.097 13.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 CCF42950.1 - 0.069 13.6 0.1 0.11 13.0 0.1 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_11 PF13086.6 CCF42950.1 - 0.088 12.6 0.0 0.12 12.1 0.0 1.1 1 0 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.17 CCF42950.1 - 0.12 11.4 0.0 0.17 11.0 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_10 PF12846.7 CCF42950.1 - 0.14 11.1 0.0 0.18 10.7 0.0 1.1 1 0 0 1 1 1 0 AAA-like domain IstB_IS21 PF01695.17 CCF42950.1 - 0.14 11.8 0.0 0.19 11.4 0.0 1.2 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_18 PF13238.6 CCF42950.1 - 0.18 12.3 0.1 0.32 11.5 0.1 1.4 1 0 0 1 1 1 0 AAA domain IL11 PF07400.11 CCF42951.1 - 0.041 13.5 0.2 0.046 13.4 0.2 1.2 1 0 0 1 1 1 0 Interleukin 11 Trp_DMAT PF11991.8 CCF42952.1 - 1.5e-66 225.3 0.0 2e-66 224.9 0.0 1.0 1 0 0 1 1 1 1 Tryptophan dimethylallyltransferase Cu_amine_oxid PF01179.20 CCF42953.1 - 5.9e-161 536.0 0.0 6.9e-161 535.7 0.0 1.0 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain KR PF08659.10 CCF42954.1 - 2.2e-25 89.6 0.0 3.9e-25 88.8 0.0 1.4 1 0 0 1 1 1 1 KR domain PP-binding PF00550.25 CCF42954.1 - 8.2e-08 32.5 0.2 1.7e-07 31.5 0.2 1.5 1 0 0 1 1 1 1 Phosphopantetheine attachment site TAP_C PF03943.13 CCF42956.1 - 1e-18 66.7 0.2 1.8e-18 65.9 0.2 1.4 1 0 0 1 1 1 1 TAP C-terminal domain LRR_4 PF12799.7 CCF42956.1 - 3.6e-08 33.6 3.1 2.2e-05 24.7 0.3 3.0 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCF42956.1 - 5.7e-06 26.0 0.1 1.5e-05 24.6 0.1 1.8 1 0 0 1 1 1 1 Leucine rich repeat NTF2 PF02136.20 CCF42956.1 - 2.7e-05 24.7 0.0 9.4e-05 23.0 0.0 2.0 1 1 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain RRM_9 PF18444.1 CCF42956.1 - 3.5e-05 23.6 0.1 0.00014 21.7 0.1 2.0 1 1 0 1 1 1 1 RNA recognition motif LRR_1 PF00560.33 CCF42956.1 - 0.023 15.2 0.1 5.4 8.0 0.0 3.3 2 0 0 2 2 2 0 Leucine Rich Repeat LRR_6 PF13516.6 CCF42956.1 - 0.42 10.8 2.5 4.3 7.7 0.0 3.3 3 0 0 3 3 3 0 Leucine Rich repeat HsbA PF12296.8 CCF42957.1 - 1.7e-25 89.8 10.5 1.7e-25 89.8 10.5 1.9 2 0 0 2 2 2 1 Hydrophobic surface binding protein A DUF3275 PF11679.8 CCF42957.1 - 0.2 11.6 1.5 23 4.9 0.0 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF3275) DUF2070 PF09843.9 CCF42958.1 - 2.4 6.4 8.2 2.5 6.3 8.2 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) TANGO2 PF05742.12 CCF42959.1 - 3.2e-68 230.5 0.0 3.7e-68 230.3 0.0 1.0 1 0 0 1 1 1 1 Transport and Golgi organisation 2 ABC_tran PF00005.27 CCF42960.1 - 5.7e-40 137.0 0.0 4.7e-19 69.3 0.0 2.4 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 CCF42960.1 - 5.4e-20 72.2 17.1 5.4e-20 72.2 17.1 3.8 3 1 1 4 4 4 1 ABC transporter transmembrane region AAA_21 PF13304.6 CCF42960.1 - 2e-11 44.3 1.6 0.00055 19.8 0.0 4.2 2 2 2 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CCF42960.1 - 8.6e-09 35.2 0.4 0.0039 16.7 0.0 4.3 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CCF42960.1 - 2.5e-06 27.1 0.1 0.077 12.7 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 CCF42960.1 - 2.8e-05 24.4 0.0 0.22 11.8 0.0 2.7 2 1 0 2 2 2 2 AAA domain AAA_16 PF13191.6 CCF42960.1 - 5.3e-05 23.7 0.2 0.36 11.2 0.1 2.6 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 CCF42960.1 - 0.00031 20.7 0.2 0.46 10.4 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 CCF42960.1 - 0.00058 19.9 0.2 1.7 8.8 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_7 PF12775.7 CCF42960.1 - 0.0018 17.8 0.0 0.71 9.4 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region T2SSE PF00437.20 CCF42960.1 - 0.0027 16.8 0.1 0.07 12.2 0.0 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein DUF4644 PF15486.6 CCF42960.1 - 0.0031 17.3 0.1 0.0066 16.2 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4644) AAA_18 PF13238.6 CCF42960.1 - 0.0069 16.9 0.0 1.6 9.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_15 PF13175.6 CCF42960.1 - 0.0075 16.0 0.0 4.2 7.0 0.0 2.1 2 0 0 2 2 2 2 AAA ATPase domain Dynamin_N PF00350.23 CCF42960.1 - 0.0086 16.1 0.7 0.82 9.7 0.1 2.3 2 0 0 2 2 2 1 Dynamin family AAA_33 PF13671.6 CCF42960.1 - 0.0088 16.2 0.0 1 9.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 CCF42960.1 - 0.011 16.2 0.0 13 6.2 0.0 3.1 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.6 CCF42960.1 - 0.011 16.2 0.1 6.8 7.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 CCF42960.1 - 0.035 13.7 0.5 9.7 5.7 0.1 3.0 3 0 0 3 3 3 0 AAA domain DUF815 PF05673.13 CCF42960.1 - 0.15 11.2 0.1 7.9 5.6 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) IstB_IS21 PF01695.17 CCF42960.1 - 0.15 11.8 0.7 33 4.1 0.0 3.6 4 0 0 4 4 4 0 IstB-like ATP binding protein PduV-EutP PF10662.9 CCF42960.1 - 0.15 11.8 0.3 3.8 7.3 0.0 2.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Dus PF01207.17 CCF42966.1 - 1.7e-54 185.0 0.0 3.2e-54 184.1 0.0 1.4 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) Dynamin_N PF00350.23 CCF42967.1 - 5.9e-18 65.5 0.1 1.7e-17 64.0 0.0 1.8 2 0 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 CCF42967.1 - 4.9e-10 39.5 0.0 3.3e-09 36.8 0.0 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CCF42967.1 - 6.8e-07 29.0 0.8 0.0005 19.7 1.0 2.6 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain cobW PF02492.19 CCF42967.1 - 0.017 14.8 0.6 0.57 9.8 0.6 2.9 2 1 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain IIGP PF05049.13 CCF42967.1 - 0.024 13.7 0.0 0.049 12.7 0.0 1.4 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) AAA_18 PF13238.6 CCF42967.1 - 0.025 15.1 0.0 0.11 13.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 CCF42967.1 - 0.032 14.1 0.3 9.2 6.1 0.1 2.9 2 1 1 3 3 3 0 RsgA GTPase Roc PF08477.13 CCF42967.1 - 0.056 13.7 0.1 0.94 9.7 0.0 2.5 1 1 1 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase DUF2408 PF10303.9 CCF42967.1 - 0.056 14.0 1.1 1.4 9.5 0.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2408) TsaE PF02367.17 CCF42967.1 - 0.062 13.3 0.0 0.16 12.0 0.0 1.7 1 1 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF489 PF04356.12 CCF42967.1 - 0.14 12.2 0.8 2.1 8.3 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF489) Aim21 PF11489.8 CCF42968.1 - 8.4e-94 315.9 21.3 8.4e-94 315.9 21.3 1.6 2 0 0 2 2 2 1 Altered inheritance of mitochondria protein 21 p47_phox_C PF08944.11 CCF42968.1 - 2.9 7.4 12.9 9.1 5.8 6.6 2.6 2 0 0 2 2 2 0 NADPH oxidase subunit p47Phox, C terminal domain SNAP-25 PF00835.19 CCF42969.1 - 0.061 13.6 0.3 0.092 13.1 0.3 1.3 1 0 0 1 1 1 0 SNAP-25 family Ras PF00071.22 CCF42970.1 - 4.9e-54 182.3 0.0 5.5e-54 182.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCF42970.1 - 1.9e-21 76.5 0.0 2.7e-21 76.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCF42970.1 - 8.6e-07 28.6 0.0 1.1e-06 28.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Aldedh PF00171.22 CCF42971.1 - 7.7e-82 275.2 0.1 8.7e-82 275.1 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family WSC PF01822.19 CCF42972.1 - 1e-31 109.0 30.5 5.2e-19 68.2 8.9 5.4 5 1 0 5 5 5 3 WSC domain SOG2 PF10428.9 CCF42972.1 - 0.72 9.0 7.7 1.1 8.4 7.7 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein PRCC PF10253.9 CCF42972.1 - 6.5 7.5 6.8 15 6.3 6.8 1.5 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting KR PF08659.10 CCF42973.1 - 3.8e-54 183.3 0.0 5.7e-54 182.8 0.0 1.3 1 0 0 1 1 1 1 KR domain adh_short PF00106.25 CCF42973.1 - 6.1e-09 35.6 0.0 1.1e-08 34.8 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase PP-binding PF00550.25 CCF42973.1 - 2.2e-08 34.3 0.1 3.8e-08 33.6 0.1 1.4 1 0 0 1 1 1 1 Phosphopantetheine attachment site adh_short_C2 PF13561.6 CCF42973.1 - 8.6e-06 25.5 0.0 1.5e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Sacchrp_dh_NADP PF03435.18 CCF42973.1 - 0.16 12.2 0.0 0.28 11.4 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain EamA PF00892.20 CCF42974.1 - 2.1e-14 53.8 34.7 1.5e-09 38.1 8.4 2.1 2 0 0 2 2 2 2 EamA-like transporter family Trp_oprn_chp PF09534.10 CCF42974.1 - 0.012 15.4 2.5 0.49 10.2 0.2 2.4 2 0 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) PTPLA PF04387.14 CCF42974.1 - 0.014 15.1 2.7 0.014 15.1 2.7 1.7 2 0 0 2 2 2 0 Protein tyrosine phosphatase-like protein, PTPLA p450 PF00067.22 CCF42975.1 - 2.1e-31 109.2 0.0 2.6e-31 108.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Het-C PF07217.11 CCF42977.1 - 8.4e-152 506.6 0.0 9.7e-152 506.4 0.0 1.0 1 0 0 1 1 1 1 Heterokaryon incompatibility protein Het-C PP2C PF00481.21 CCF42978.1 - 3.9e-17 62.7 0.0 4.9e-17 62.4 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 CCF42978.1 - 0.064 13.2 0.0 0.081 12.8 0.0 1.1 1 0 0 1 1 1 0 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 CCF42978.1 - 0.082 12.5 0.0 0.093 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein phosphatase 2C Acyl_transf_1 PF00698.21 CCF42979.1 - 9.4e-41 140.3 6.7 1.1e-33 117.2 6.8 2.7 2 1 0 2 2 2 2 Acyl transferase domain Ketoacyl-synt_C PF02801.22 CCF42979.1 - 1.4e-32 112.2 0.2 3.2e-32 111.0 0.2 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain ketoacyl-synt PF00109.26 CCF42979.1 - 3.9e-12 46.3 1.8 1.7e-11 44.2 0.1 2.4 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain KAsynt_C_assoc PF16197.5 CCF42979.1 - 1.6e-11 44.7 0.0 4.8e-10 39.9 0.0 2.4 2 0 0 2 2 2 1 Ketoacyl-synthetase C-terminal extension SAT PF16073.5 CCF42979.1 - 2e-07 31.0 0.2 3.4e-07 30.3 0.2 1.3 1 0 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis NUDIX PF00293.28 CCF42979.1 - 0.097 12.7 0.0 0.23 11.5 0.0 1.6 1 0 0 1 1 1 0 NUDIX domain Med11 PF10280.9 CCF42981.1 - 8.8e-50 168.7 0.0 1.1e-49 168.5 0.0 1.1 1 0 0 1 1 1 1 Mediator complex protein DUF4918 PF16265.5 CCF42981.1 - 0.051 13.1 0.1 0.15 11.6 0.0 1.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4918) UBA PF00627.31 CCF42982.1 - 0.0042 17.0 0.1 0.0088 15.9 0.1 1.6 1 0 0 1 1 1 1 UBA/TS-N domain adh_short_C2 PF13561.6 CCF42984.1 - 3.4e-34 118.4 0.0 6.3e-34 117.6 0.0 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF42984.1 - 1.9e-24 86.2 0.0 2.4e-24 85.9 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase Zn_clus PF00172.18 CCF42985.1 - 2.7e-07 30.6 6.1 4.1e-07 30.0 6.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain UDPGP PF01704.18 CCF42986.1 - 3.2e-193 642.0 0.1 3.7e-193 641.8 0.1 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase DUF3605 PF12239.8 CCF42987.1 - 8.2e-56 188.6 0.1 9.7e-56 188.3 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3605) FolB PF02152.18 CCF42988.1 - 4.3e-25 88.4 0.0 6.2e-19 68.6 0.0 2.2 2 0 0 2 2 2 2 Dihydroneopterin aldolase ERAP1_C PF11838.8 CCF42989.1 - 6.5e-86 288.7 1.4 1.7e-85 287.3 1.1 1.8 2 0 0 2 2 2 1 ERAP1-like C-terminal domain Peptidase_M1 PF01433.20 CCF42989.1 - 2.1e-83 279.2 0.1 3.3e-83 278.6 0.1 1.3 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 CCF42989.1 - 6.9e-57 192.6 0.1 5.8e-56 189.6 0.1 2.1 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain Enolase_N PF03952.16 CCF42990.1 - 1.3e-47 161.2 0.2 1.5e-47 161.1 0.2 1.0 1 0 0 1 1 1 1 Enolase, N-terminal domain MFS_1 PF07690.16 CCF42992.1 - 5.2e-26 91.4 22.1 8.7e-25 87.4 17.5 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Amidase PF01425.21 CCF42993.1 - 9.4e-92 308.3 0.0 1.7e-91 307.5 0.0 1.4 1 1 0 1 1 1 1 Amidase Amino_oxidase PF01593.24 CCF42994.1 - 1.7e-51 175.9 0.1 2.3e-51 175.5 0.1 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase Ribonuc_L-PSP PF01042.21 CCF42994.1 - 2.2e-15 56.7 0.1 4.9e-15 55.6 0.1 1.5 1 0 0 1 1 1 1 Endoribonuclease L-PSP NAD_binding_8 PF13450.6 CCF42994.1 - 2.5e-13 50.1 0.2 7.5e-13 48.5 0.2 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 CCF42994.1 - 9.1e-09 34.9 0.6 1.7e-08 34.0 0.6 1.4 1 0 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.12 CCF42994.1 - 3.5e-07 29.6 0.0 5.8e-06 25.6 0.1 2.1 2 0 0 2 2 2 1 Lycopene cyclase protein Thi4 PF01946.17 CCF42994.1 - 4.5e-06 26.1 0.0 8.4e-06 25.2 0.0 1.3 1 0 0 1 1 1 1 Thi4 family FAD_oxidored PF12831.7 CCF42994.1 - 1e-05 25.1 0.1 1.5e-05 24.6 0.1 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO PF01266.24 CCF42994.1 - 1.9e-05 24.4 0.1 4.4e-05 23.2 0.1 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 CCF42994.1 - 0.00024 20.5 0.7 0.00036 19.9 0.7 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CCF42994.1 - 0.00026 20.4 0.0 0.0004 19.7 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CCF42994.1 - 0.00042 19.1 0.3 0.00082 18.2 0.3 1.4 1 0 0 1 1 1 1 HI0933-like protein GIDA PF01134.22 CCF42994.1 - 0.0017 17.5 0.7 0.0029 16.7 0.7 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 CCF42994.1 - 0.0084 15.4 0.1 0.018 14.4 0.1 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_3 PF13738.6 CCF42994.1 - 0.027 13.7 0.2 0.027 13.7 0.2 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCF42994.1 - 0.083 13.5 0.1 0.17 12.4 0.1 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Aldolase_II PF00596.21 CCF42995.1 - 7.6e-49 166.2 0.1 9.7e-49 165.8 0.1 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Hce2 PF14856.6 CCF42996.1 - 1.3e-19 70.4 0.1 1.6e-19 70.1 0.1 1.1 1 0 0 1 1 1 1 Pathogen effector; putative necrosis-inducing factor HET PF06985.11 CCF42997.1 - 7.7e-25 87.9 0.0 1.4e-24 87.1 0.0 1.5 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Pkinase PF00069.25 CCF42997.1 - 0.00019 20.9 0.0 0.00034 20.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Arginase PF00491.21 CCF42998.1 - 2.7e-80 269.9 0.5 3.5e-80 269.5 0.5 1.0 1 0 0 1 1 1 1 Arginase family CHASE2 PF05226.11 CCF42998.1 - 0.063 13.0 0.1 0.12 12.1 0.1 1.4 1 0 0 1 1 1 0 CHASE2 domain SnoaL_2 PF12680.7 CCF43000.1 - 2.6e-05 24.8 0.0 3.6e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 SnoaL-like domain DUF2358 PF10184.9 CCF43000.1 - 0.00028 21.1 0.0 0.00043 20.5 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2358) TonB_2 PF13103.6 CCF43000.1 - 0.038 14.3 0.1 0.077 13.2 0.1 1.5 1 0 0 1 1 1 0 TonB C terminal Oxidored_FMN PF00724.20 CCF43004.1 - 5.9e-63 213.2 0.0 7.6e-63 212.8 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Dus PF01207.17 CCF43004.1 - 0.0016 17.6 0.1 0.006 15.7 0.0 1.9 2 0 0 2 2 2 1 Dihydrouridine synthase (Dus) Fungal_trans_2 PF11951.8 CCF43005.1 - 0.00032 19.6 0.9 0.084 11.7 0.1 2.1 2 0 0 2 2 2 2 Fungal specific transcription factor domain bZIP_1 PF00170.21 CCF43006.1 - 2.5e-08 33.9 8.4 3.1e-08 33.6 8.4 1.1 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 CCF43006.1 - 1.1e-06 28.7 10.2 1.5e-06 28.2 10.2 1.2 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 CCF43006.1 - 0.00012 22.5 6.3 0.00016 22.2 6.3 1.1 1 0 0 1 1 1 1 bZIP Maf transcription factor Takusan PF04822.13 CCF43006.1 - 0.00033 20.5 1.8 0.00047 20.0 1.8 1.3 1 0 0 1 1 1 1 Takusan TMF_DNA_bd PF12329.8 CCF43006.1 - 0.033 14.2 2.5 0.048 13.7 2.3 1.4 1 1 0 1 1 1 0 TATA element modulatory factor 1 DNA binding RFamide_26RFa PF11109.8 CCF43006.1 - 0.073 13.6 1.4 0.091 13.3 1.4 1.3 1 1 0 1 1 1 0 Orexigenic neuropeptide Qrfp/P518 PKcGMP_CC PF16808.5 CCF43006.1 - 1.4 8.8 7.2 4.5 7.2 3.5 2.2 1 1 1 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF1635 PF07795.11 CCF43006.1 - 6.7 6.5 7.1 0.81 9.5 3.2 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1635) Aldedh PF00171.22 CCF43009.1 - 3.3e-133 444.6 0.0 4.1e-133 444.3 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 CCF43009.1 - 0.0019 17.3 0.1 0.0042 16.2 0.1 1.6 1 1 0 1 1 1 1 Acyl-CoA reductase (LuxC) DTHCT PF08070.11 CCF43010.1 - 0.16 12.7 15.1 0.51 11.1 14.9 1.8 1 1 0 1 1 1 0 DTHCT (NUC029) region Nop14 PF04147.12 CCF43010.1 - 0.53 8.4 18.4 0.62 8.2 18.4 1.0 1 0 0 1 1 1 0 Nop14-like family GCP_C_terminal PF04130.13 CCF43013.1 - 5.9e-24 85.1 0.0 6.8e-24 84.9 0.0 1.1 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal DUF3437 PF11919.8 CCF43014.1 - 0.36 10.8 1.9 1.2 9.1 1.9 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF3437) DUF4215 PF13948.6 CCF43016.1 - 0.21 12.0 6.3 0.34 11.4 6.3 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4215) EGF PF00008.27 CCF43016.1 - 0.72 10.2 7.8 0.31 11.4 4.9 2.0 1 1 1 2 2 2 0 EGF-like domain Glyco_hydro_79C PF16862.5 CCF43017.1 - 7.3e-21 75.0 0.1 9.4e-21 74.6 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 79 C-terminal beta domain Ysc84 PF04366.12 CCF43018.1 - 7.3e-52 174.5 0.1 1.2e-51 173.8 0.1 1.4 1 0 0 1 1 1 1 Las17-binding protein actin regulator Glyco_transf_28 PF03033.20 CCF43019.1 - 4.7e-19 68.8 0.0 8.5e-19 68.0 0.0 1.4 1 1 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain HTH_Tnp_Tc5 PF03221.16 CCF43022.1 - 4.6e-12 45.8 0.2 1.5e-11 44.1 0.0 2.0 3 0 0 3 3 3 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 CCF43022.1 - 5.7e-09 35.6 0.0 1e-08 34.8 0.0 1.4 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_23 PF13384.6 CCF43022.1 - 0.0061 16.3 0.3 0.02 14.7 0.1 2.0 2 0 0 2 2 2 1 Homeodomain-like domain DDE_1 PF03184.19 CCF43022.1 - 0.026 14.2 0.0 0.072 12.7 0.0 1.7 2 0 0 2 2 2 0 DDE superfamily endonuclease CENP-B_N PF04218.13 CCF43022.1 - 0.029 14.0 0.0 0.053 13.2 0.0 1.4 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HTH_28 PF13518.6 CCF43022.1 - 0.11 12.7 0.2 0.39 10.9 0.0 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain TIM PF00121.18 CCF43023.1 - 8.8e-55 185.7 0.0 9.9e-55 185.5 0.0 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase LacAB_rpiB PF02502.18 CCF43024.1 - 6.8e-42 142.8 0.2 7.7e-42 142.6 0.2 1.0 1 0 0 1 1 1 1 Ribose/Galactose Isomerase Dak1 PF02733.17 CCF43025.1 - 2.7e-98 328.7 0.0 3.6e-98 328.3 0.0 1.1 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.17 CCF43025.1 - 4.2e-42 144.0 0.2 6.4e-42 143.4 0.2 1.3 1 0 0 1 1 1 1 DAK2 domain Fungal_trans PF04082.18 CCF43026.1 - 4.7e-24 84.9 0.1 8.6e-24 84.0 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF43026.1 - 0.00051 20.1 10.7 0.001 19.1 10.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CKS PF01111.19 CCF43027.1 - 1.6e-34 118.0 1.5 2.4e-34 117.4 1.5 1.3 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit Indigoidine_A PF04227.12 CCF43028.1 - 3.5e-107 358.1 1.6 4.5e-107 357.7 1.6 1.1 1 0 0 1 1 1 1 Indigoidine synthase A like protein PfkB PF00294.24 CCF43028.1 - 5.3e-05 22.7 0.0 9.1e-05 21.9 0.0 1.4 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Sugar_tr PF00083.24 CCF43029.1 - 1.7e-50 172.2 12.3 2.2e-50 171.9 12.3 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF43029.1 - 1.4e-23 83.5 21.3 2.4e-23 82.6 21.3 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily HET PF06985.11 CCF43030.1 - 4.9e-20 72.4 0.0 7.6e-20 71.7 0.0 1.3 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Hid1 PF12722.7 CCF43031.1 - 5.3e-39 134.0 0.0 5.9e-39 133.9 0.0 1.0 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein His_Phos_2 PF00328.22 CCF43033.1 - 8.1e-34 117.6 0.0 1.3e-33 116.9 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Ribosomal_L19e PF01280.20 CCF43033.1 - 0.074 13.1 2.3 1.3 9.1 0.3 2.5 2 1 0 2 2 2 0 Ribosomal protein L19e Myb_DNA-bind_6 PF13921.6 CCF43036.1 - 6.6e-05 23.1 0.5 0.00012 22.3 0.5 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain DUF688 PF05097.12 CCF43036.1 - 0.014 14.6 0.1 0.018 14.2 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF688) Myb_DNA-binding PF00249.31 CCF43036.1 - 0.052 13.7 0.8 0.095 12.9 0.8 1.4 1 0 0 1 1 1 0 Myb-like DNA-binding domain DAO PF01266.24 CCF43039.1 - 2.4e-32 112.9 0.2 2.7e-32 112.7 0.2 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Glu_dehyd_C PF16912.5 CCF43039.1 - 0.05 13.1 0.0 0.09 12.3 0.0 1.4 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus APH PF01636.23 CCF43042.1 - 2.8e-17 63.4 0.0 4.5e-17 62.8 0.0 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CCF43042.1 - 0.028 14.0 0.0 0.045 13.3 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase HP1451_C PF18472.1 CCF43043.1 - 0.19 11.7 0.1 2 8.5 0.0 2.1 2 0 0 2 2 2 0 HP1451 C-terminal domain Condensation PF00668.20 CCF43044.1 - 6.1e-43 147.1 0.0 2.4e-23 82.6 0.0 4.0 4 1 0 4 4 4 3 Condensation domain BCL_N PF04714.13 CCF43044.1 - 0.087 12.9 0.2 0.2 11.8 0.2 1.6 1 0 0 1 1 1 0 BCL7, N-terminal conserver region Cyclin_N PF00134.23 CCF43045.1 - 2.6e-11 43.4 0.2 4.6e-11 42.5 0.2 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C_2 PF16899.5 CCF43045.1 - 0.0029 18.0 0.2 0.014 15.7 0.1 2.2 2 0 0 2 2 2 1 Cyclin C-terminal domain Las1 PF04031.13 CCF43045.1 - 0.046 13.9 1.4 12 6.0 0.0 3.0 2 1 0 3 3 3 0 Las1-like TFIIB PF00382.19 CCF43045.1 - 0.11 12.5 0.1 0.11 12.5 0.1 1.8 2 0 0 2 2 2 0 Transcription factor TFIIB repeat WSD PF15613.6 CCF43046.1 - 5.9e-18 65.2 0.1 5.9e-18 65.2 0.1 4.0 4 1 0 4 4 4 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif DDT PF02791.17 CCF43046.1 - 2.4e-16 59.8 0.4 4.6e-16 58.9 0.4 1.4 1 0 0 1 1 1 1 DDT domain WHIM1 PF15612.6 CCF43046.1 - 9.7e-07 28.2 0.1 5.1e-06 25.9 0.0 2.2 2 0 0 2 2 2 1 WSTF, HB1, Itc1p, MBD9 motif 1 DUF2052 PF09747.9 CCF43046.1 - 1.7 8.7 38.8 0.38 10.9 4.8 3.3 3 0 0 3 3 3 0 Coiled-coil domain containing protein (DUF2052) Nop53 PF07767.11 CCF43046.1 - 2.7 7.3 51.8 0.18 11.2 17.4 3.4 3 0 0 3 3 3 0 Nop53 (60S ribosomal biogenesis) ABC_tran PF00005.27 CCF43047.1 - 1.9e-17 64.1 0.0 4.6e-17 62.8 0.0 1.7 1 1 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 CCF43047.1 - 5.8e-15 55.7 0.2 9.4e-15 55.0 0.2 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region AAA_25 PF13481.6 CCF43047.1 - 0.00063 19.4 0.0 0.0012 18.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CCF43047.1 - 0.0012 19.3 0.1 0.0045 17.4 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 CCF43047.1 - 0.014 15.1 0.3 0.045 13.5 0.3 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain SMC_N PF02463.19 CCF43047.1 - 0.021 14.2 0.0 3.9 6.9 0.0 2.1 1 1 0 2 2 2 0 RecF/RecN/SMC N terminal domain Viral_helicase1 PF01443.18 CCF43047.1 - 0.025 14.3 0.0 0.041 13.6 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_23 PF13476.6 CCF43047.1 - 0.033 14.7 0.1 0.053 14.0 0.1 1.2 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 CCF43047.1 - 0.05 13.2 0.0 0.089 12.4 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_28 PF13521.6 CCF43047.1 - 0.085 13.1 0.0 0.17 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 CCF43047.1 - 0.17 11.9 0.0 0.35 10.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 CCF43047.1 - 0.22 11.9 0.0 0.65 10.4 0.0 1.8 2 0 0 2 2 2 0 RNA helicase Alpha-amylase PF00128.24 CCF43048.1 - 1.5e-10 41.2 0.0 2e-10 40.8 0.0 1.1 1 0 0 1 1 1 1 Alpha amylase, catalytic domain DUF1939 PF09154.10 CCF43048.1 - 0.013 15.6 0.1 0.022 14.9 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1939) DUF676 PF05057.14 CCF43049.1 - 1e-42 146.2 0.0 2.6e-27 95.8 0.0 3.2 3 0 0 3 3 3 3 Putative serine esterase (DUF676) PGAP1 PF07819.13 CCF43049.1 - 0.11 12.2 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 PGAP1-like protein Lipase_3 PF01764.25 CCF43049.1 - 0.14 12.0 0.0 0.37 10.6 0.0 1.6 1 0 0 1 1 1 0 Lipase (class 3) DDE_1 PF03184.19 CCF43051.1 - 7.1e-28 97.4 0.0 1.8e-27 96.1 0.0 1.6 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_psq PF05225.16 CCF43051.1 - 2.9e-08 33.3 0.8 9e-08 31.7 0.0 2.2 2 0 0 2 2 2 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.16 CCF43051.1 - 3.7e-06 26.9 0.0 1e-05 25.5 0.0 1.9 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DDE_3 PF13358.6 CCF43051.1 - 0.00021 21.0 0.1 0.0077 16.0 0.0 2.4 2 0 0 2 2 2 1 DDE superfamily endonuclease Phostensin_N PF13916.6 CCF43051.1 - 0.022 15.1 0.3 0.16 12.3 0.1 2.2 1 1 1 2 2 2 0 PP1-regulatory protein, Phostensin N-terminal peroxidase PF00141.23 CCF43052.1 - 4.8e-49 167.1 0.0 7.9e-49 166.4 0.0 1.3 1 0 0 1 1 1 1 Peroxidase DUF1972 PF09314.11 CCF43052.1 - 0.31 10.6 1.2 0.49 10.0 1.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1972) ATP11 PF06644.11 CCF43053.1 - 1.2e-102 343.4 0.0 1.4e-102 343.2 0.0 1.0 1 0 0 1 1 1 1 ATP11 protein Sel1 PF08238.12 CCF43054.1 - 1.9e-39 133.2 30.7 2.6e-05 24.8 0.3 7.5 7 0 0 7 7 7 7 Sel1 repeat Glyoxalase PF00903.25 CCF43055.1 - 4.3e-06 26.9 6.7 0.0014 18.8 2.3 2.7 2 1 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily TPR_2 PF07719.17 CCF43055.1 - 0.14 12.3 0.1 2.7 8.3 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_3 PF07720.12 CCF43055.1 - 0.24 11.4 2.1 2 8.5 0.2 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 CCF43055.1 - 0.25 11.2 0.6 3.6 7.6 0.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat GATA PF00320.27 CCF43056.1 - 0.00024 20.6 5.7 0.019 14.6 1.6 2.5 2 0 0 2 2 2 2 GATA zinc finger Metallophos PF00149.28 CCF43057.1 - 9.8e-09 36.0 0.5 1.3e-08 35.6 0.5 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase ssDNA-exonuc_C PF10141.9 CCF43058.1 - 0.078 12.6 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 Single-strand DNA-specific exonuclease, C terminal domain Gly-zipper_Omp PF13488.6 CCF43061.1 - 1.5 8.9 8.8 4.1 7.5 8.8 1.7 1 0 0 1 1 1 0 Glycine zipper Pyr_redox_2 PF07992.14 CCF43062.1 - 8.2e-62 209.1 0.2 1.3e-61 208.4 0.2 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 CCF43062.1 - 5e-33 113.7 0.4 1.1e-32 112.5 0.4 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 CCF43062.1 - 1.2e-19 70.6 0.4 2.3e-18 66.5 0.0 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCF43062.1 - 5.1e-14 52.2 0.0 7.1e-14 51.7 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CCF43062.1 - 2.7e-05 23.5 0.0 8.9e-05 21.8 0.0 1.7 1 1 1 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.14 CCF43062.1 - 0.00067 18.5 1.6 3.5 6.2 0.5 3.2 3 1 0 3 3 3 3 HI0933-like protein FAD_oxidored PF12831.7 CCF43062.1 - 0.0064 15.9 0.1 0.012 15.0 0.1 1.5 2 0 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.22 CCF43062.1 - 0.039 13.0 0.4 0.08 12.0 0.1 1.8 3 0 0 3 3 3 0 Glucose inhibited division protein A FAD_binding_2 PF00890.24 CCF43062.1 - 0.12 11.4 2.8 1.2 8.2 1.4 2.2 2 0 0 2 2 2 0 FAD binding domain Thi4 PF01946.17 CCF43062.1 - 0.21 10.8 2.5 0.13 11.5 0.4 1.7 2 0 0 2 2 2 0 Thi4 family MSA-2c PF12238.8 CCF43063.1 - 0.016 15.3 2.8 0.018 15.0 2.8 1.1 1 0 0 1 1 1 0 Merozoite surface antigen 2c ADH_zinc_N PF00107.26 CCF43064.1 - 2.5e-20 72.8 0.0 3.8e-20 72.2 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 CCF43064.1 - 8.6e-19 67.4 0.0 1.5e-18 66.7 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N_2 PF13602.6 CCF43064.1 - 8.5e-07 30.1 0.0 1.9e-06 29.0 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase DUF5437 PF17505.2 CCF43066.1 - 4.8 7.3 7.9 3.7 7.7 6.1 1.8 1 1 0 1 1 1 0 Family of unknown function (DUF5437) PhoLip_ATPase_N PF16209.5 CCF43067.1 - 8.2e-18 63.9 0.2 1.6e-17 62.9 0.2 1.4 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.20 CCF43067.1 - 8.5e-10 38.4 0.0 1.6e-09 37.5 0.0 1.4 1 0 0 1 1 1 1 E1-E2 ATPase Erv26 PF04148.13 CCF43067.1 - 0.005 16.7 0.3 1.1 9.0 0.0 2.3 2 0 0 2 2 2 2 Transmembrane adaptor Erv26 Cutinase PF01083.22 CCF43068.1 - 8.9e-44 149.6 0.1 1.1e-43 149.2 0.1 1.1 1 0 0 1 1 1 1 Cutinase PE-PPE PF08237.11 CCF43068.1 - 0.0088 15.6 0.0 0.015 14.9 0.0 1.4 1 0 0 1 1 1 1 PE-PPE domain VirJ PF06057.11 CCF43068.1 - 0.019 14.8 0.0 0.03 14.2 0.0 1.2 1 0 0 1 1 1 0 Bacterial virulence protein (VirJ) VPS9 PF02204.18 CCF43069.1 - 4.2e-29 100.8 0.1 8.6e-29 99.8 0.1 1.5 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain DUF5601 PF18151.1 CCF43069.1 - 9.5e-17 61.1 0.1 2e-16 60.1 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF5601) CUE PF02845.16 CCF43069.1 - 1.1e-08 34.6 0.1 9.2e-08 31.7 0.0 2.2 2 0 0 2 2 2 1 CUE domain NdhL PF10716.9 CCF43070.1 - 0.0087 16.0 0.9 0.0087 16.0 0.9 2.1 2 0 0 2 2 2 1 NADH dehydrogenase transmembrane subunit UPF0697 PF15117.6 CCF43070.1 - 0.082 13.0 0.3 0.15 12.2 0.3 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0697 Acyl_transf_3 PF01757.22 CCF43071.1 - 6.2e-32 111.0 32.4 3.8e-31 108.4 32.4 2.2 1 1 0 1 1 1 1 Acyltransferase family CReP_N PF10472.9 CCF43071.1 - 0.0037 16.2 0.3 0.0056 15.6 0.3 1.2 1 0 0 1 1 1 1 eIF2-alpha phosphatase phosphorylation constitutive repressor Abhydrolase_1 PF00561.20 CCF43072.1 - 7.9e-19 68.3 0.0 3.8e-18 66.0 0.0 1.9 1 1 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCF43072.1 - 6.7e-14 53.0 0.0 8.8e-14 52.6 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCF43072.1 - 7.3e-13 48.3 0.0 1.4e-12 47.4 0.0 1.5 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.14 CCF43072.1 - 4e-05 22.5 0.0 6.2e-05 21.8 0.0 1.2 1 0 0 1 1 1 1 Ndr family Abhydrolase_5 PF12695.7 CCF43072.1 - 0.11 12.3 0.0 0.26 11.0 0.0 1.6 2 0 0 2 2 2 0 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 CCF43072.1 - 0.13 11.7 0.1 18 4.7 0.0 2.6 3 0 0 3 3 3 0 Prolyl oligopeptidase family Clr5 PF14420.6 CCF43073.1 - 1.1e-16 60.7 0.4 1.1e-16 60.7 0.4 1.5 2 0 0 2 2 2 1 Clr5 domain KRAB PF01352.27 CCF43073.1 - 0.098 12.3 0.0 1.2 8.8 0.0 2.2 2 0 0 2 2 2 0 KRAB box WD40 PF00400.32 CCF43074.1 - 2.4e-52 173.7 16.7 1.9e-09 37.9 0.6 8.5 8 1 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF43074.1 - 5.5e-13 49.0 0.1 0.00038 20.7 0.1 4.6 3 1 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CCF43074.1 - 1.4e-08 33.9 0.3 0.00092 18.0 0.1 4.4 4 1 0 4 4 4 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 CCF43074.1 - 8.4e-06 24.8 0.0 0.0045 15.8 0.0 2.8 3 0 0 3 3 3 2 Nup133 N terminal like GidB PF02527.15 CCF43076.1 - 0.03 13.6 0.5 0.038 13.3 0.5 1.1 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G Augurin PF15187.6 CCF43076.1 - 0.061 13.5 0.2 0.12 12.5 0.2 1.5 1 1 0 1 1 1 0 Oesophageal cancer-related gene 4 PSI_integrin PF17205.3 CCF43076.1 - 0.12 12.1 2.6 0.32 10.8 2.6 1.7 1 1 0 1 1 1 0 Integrin plexin domain FUSC PF04632.12 CCF43076.1 - 0.18 10.3 1.0 0.21 10.1 1.0 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF3450 PF11932.8 CCF43076.1 - 0.27 10.5 5.0 0.36 10.1 5.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DUF4446 PF14584.6 CCF43076.1 - 0.58 10.1 3.1 1.1 9.3 0.9 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) DHR10 PF18595.1 CCF43076.1 - 1.5 8.9 13.6 0.39 10.8 6.5 2.1 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain DDE_1 PF03184.19 CCF43077.1 - 7e-12 45.3 0.0 1.4e-11 44.3 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_psq PF05225.16 CCF43077.1 - 1.3e-10 40.8 0.0 2.6e-10 39.8 0.0 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.16 CCF43077.1 - 8.9e-09 35.3 0.0 2.1e-08 34.0 0.0 1.6 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_23 PF13384.6 CCF43077.1 - 0.0094 15.7 0.1 0.061 13.1 0.0 2.2 2 0 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.6 CCF43077.1 - 0.072 13.2 0.1 0.45 10.7 0.0 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain bZIP_1 PF00170.21 CCF43078.1 - 0.37 10.9 2.9 0.78 9.9 2.9 1.5 1 0 0 1 1 1 0 bZIP transcription factor Pyr_redox_3 PF13738.6 CCF43080.1 - 2.2e-18 66.6 0.0 3.6e-18 65.9 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CCF43080.1 - 6.4e-15 55.2 0.0 8.8e-15 54.7 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 CCF43080.1 - 1.6e-12 46.6 0.0 3e-12 45.8 0.0 1.5 1 1 1 2 2 2 1 Flavin-binding monooxygenase-like K_oxygenase PF13434.6 CCF43080.1 - 2.5e-10 40.1 0.0 5.9e-10 38.8 0.0 1.6 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox PF00070.27 CCF43080.1 - 8.3e-05 23.1 0.0 1.5 9.5 0.0 3.2 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 CCF43080.1 - 0.00023 20.6 0.0 0.0011 18.3 0.0 1.9 2 0 0 2 2 2 1 FAD binding domain Shikimate_DH PF01488.20 CCF43080.1 - 0.00029 20.9 0.0 0.01 15.9 0.0 2.2 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 CCF43080.1 - 0.00032 20.1 0.1 0.0056 16.1 0.0 2.1 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DAO PF01266.24 CCF43080.1 - 0.0028 17.3 0.0 0.84 9.2 0.0 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CCF43080.1 - 0.0031 16.6 0.0 0.73 8.8 0.1 2.3 2 0 0 2 2 2 2 FAD binding domain GIDA PF01134.22 CCF43080.1 - 0.021 13.9 0.0 0.052 12.6 0.0 1.6 2 0 0 2 2 2 0 Glucose inhibited division protein A NAD_binding_8 PF13450.6 CCF43080.1 - 0.049 13.9 0.0 0.12 12.6 0.0 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain IlvN PF07991.12 CCF43080.1 - 0.065 12.8 0.1 0.8 9.3 0.1 2.1 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain ApbA PF02558.16 CCF43080.1 - 0.079 12.6 0.0 0.45 10.2 0.0 2.1 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA UDPG_MGDP_dh_N PF03721.14 CCF43080.1 - 0.11 12.1 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ubiquitin PF00240.23 CCF43081.1 - 1.6e-06 27.8 0.2 3.7e-06 26.6 0.2 1.5 1 1 0 1 1 1 1 Ubiquitin family DUF2407 PF10302.9 CCF43081.1 - 3e-05 24.5 0.0 0.0001 22.8 0.0 1.9 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Rad60-SLD PF11976.8 CCF43081.1 - 0.11 12.3 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like PS_Dcarbxylase PF02666.15 CCF43082.1 - 7.9e-69 231.2 0.0 3.1e-68 229.3 0.0 1.8 1 1 0 1 1 1 1 Phosphatidylserine decarboxylase Biotin_lipoyl PF00364.22 CCF43082.1 - 0.079 12.8 0.0 0.19 11.6 0.0 1.6 1 0 0 1 1 1 0 Biotin-requiring enzyme Nitroreductase PF00881.24 CCF43083.1 - 2.2e-16 60.4 0.0 2.6e-16 60.1 0.0 1.0 1 0 0 1 1 1 1 Nitroreductase family COesterase PF00135.28 CCF43084.1 - 3.7e-77 260.3 0.0 4.5e-77 260.1 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CCF43084.1 - 4.3e-06 26.7 0.1 0.018 14.9 0.0 2.4 2 0 0 2 2 2 2 alpha/beta hydrolase fold 4HB_MCP_1 PF12729.7 CCF43085.1 - 0.0016 18.0 0.2 0.0016 18.0 0.2 1.6 2 0 0 2 2 2 1 Four helix bundle sensory module for signal transduction SesA PF17107.5 CCF43085.1 - 0.0044 17.2 0.1 0.0085 16.3 0.1 1.5 1 0 0 1 1 1 1 N-terminal domain on NACHT_NTPase and P-loop NTPases GRAB PF10375.9 CCF43087.1 - 2.7e-09 36.6 0.1 5.8e-09 35.5 0.1 1.6 1 0 0 1 1 1 1 GRIP-related Arf-binding domain Spc7 PF08317.11 CCF43087.1 - 0.00019 20.4 31.8 0.00019 20.4 31.8 2.9 1 1 1 2 2 2 1 Spc7 kinetochore protein Filament PF00038.21 CCF43087.1 - 0.00097 18.8 57.3 0.13 11.8 31.6 2.3 1 1 1 2 2 2 2 Intermediate filament protein CENP-F_leu_zip PF10473.9 CCF43087.1 - 0.0038 17.2 30.9 0.0038 17.2 30.9 3.1 1 1 2 3 3 3 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 JIP_LZII PF16471.5 CCF43087.1 - 0.013 15.7 4.0 0.013 15.7 4.0 6.4 4 2 2 6 6 6 0 JNK-interacting protein leucine zipper II TPR_MLP1_2 PF07926.12 CCF43087.1 - 0.023 14.7 72.9 0.11 12.6 26.7 4.7 3 1 1 4 4 3 0 TPR/MLP1/MLP2-like protein Fib_alpha PF08702.10 CCF43087.1 - 0.036 14.2 35.8 0.5 10.6 9.8 4.1 1 1 3 4 4 4 0 Fibrinogen alpha/beta chain family Golgin_A5 PF09787.9 CCF43087.1 - 0.052 13.0 60.9 0.12 11.8 30.6 3.5 1 1 2 3 3 3 0 Golgin subfamily A member 5 DUF1664 PF07889.12 CCF43087.1 - 0.072 13.1 32.3 0.23 11.5 4.5 4.2 1 1 3 4 4 4 0 Protein of unknown function (DUF1664) Atg14 PF10186.9 CCF43087.1 - 0.16 11.0 49.2 0.062 12.4 20.7 3.2 1 1 2 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF745 PF05335.13 CCF43087.1 - 0.19 11.4 48.1 0.18 11.5 11.9 3.4 1 1 2 3 3 3 0 Protein of unknown function (DUF745) Occludin_ELL PF07303.13 CCF43087.1 - 0.45 11.3 33.4 0.8 10.5 4.6 4.4 1 1 4 5 5 4 0 Occludin homology domain ZYG-11_interact PF05884.12 CCF43087.1 - 0.58 9.5 16.5 5.2 6.4 2.1 3.0 2 1 0 2 2 2 0 Interactor of ZYG-11 DUF4407 PF14362.6 CCF43087.1 - 0.69 9.2 49.1 6.5 6.0 13.6 3.3 1 1 0 2 2 2 0 Domain of unknown function (DUF4407) DUF3584 PF12128.8 CCF43087.1 - 0.69 7.3 58.8 0.099 10.1 41.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) DUF641 PF04859.12 CCF43087.1 - 1.1 9.6 43.8 1.2 9.5 9.9 4.1 3 1 1 4 4 3 0 Plant protein of unknown function (DUF641) AIP3 PF03915.13 CCF43087.1 - 1.2 8.2 40.1 0.022 13.8 20.4 3.0 1 1 1 3 3 3 0 Actin interacting protein 3 AAA_13 PF13166.6 CCF43087.1 - 1.3 7.6 47.9 0.33 9.6 15.8 3.2 1 1 2 3 3 3 0 AAA domain YkyA PF10368.9 CCF43087.1 - 1.5 8.4 49.7 0.12 12.0 21.5 3.0 1 1 0 2 2 2 0 Putative cell-wall binding lipoprotein NPV_P10 PF05531.12 CCF43087.1 - 1.6 9.3 21.5 0.22 12.0 0.6 4.8 2 2 1 3 3 3 0 Nucleopolyhedrovirus P10 protein GAS PF13851.6 CCF43087.1 - 2.2 7.6 60.6 0.56 9.5 16.4 4.1 1 1 3 4 4 4 0 Growth-arrest specific micro-tubule binding CorA PF01544.18 CCF43087.1 - 2.3 7.5 30.4 0.012 15.0 10.8 3.0 2 1 1 3 3 3 0 CorA-like Mg2+ transporter protein Prominin PF05478.11 CCF43087.1 - 3.8 5.4 27.1 2.1 6.2 4.8 2.4 1 1 1 2 2 2 0 Prominin Baculo_PEP_C PF04513.12 CCF43087.1 - 4.4 7.4 24.4 0.36 10.9 4.2 3.9 1 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus APG17 PF04108.12 CCF43087.1 - 4.5 6.3 44.2 2.4 7.2 11.1 3.6 1 1 3 4 4 4 0 Autophagy protein Apg17 FPP PF05911.11 CCF43087.1 - 5.3 5.1 58.7 1.1 7.3 30.6 2.1 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil SHE3 PF17078.5 CCF43087.1 - 5.6 6.6 45.2 7.8 6.1 9.8 2.5 1 1 1 2 2 2 0 SWI5-dependent HO expression protein 3 DUF4201 PF13870.6 CCF43087.1 - 5.8 6.6 49.6 1.4 8.6 11.1 4.3 1 1 3 4 4 4 0 Domain of unknown function (DUF4201) EzrA PF06160.12 CCF43087.1 - 7.8 4.5 46.7 2.3 6.3 7.6 3.0 1 1 1 3 3 3 0 Septation ring formation regulator, EzrA E1-E2_ATPase PF00122.20 CCF43088.1 - 7.3e-31 107.1 0.0 1.3e-30 106.3 0.0 1.3 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 CCF43088.1 - 3.5e-14 53.6 0.1 9.2e-06 26.1 0.0 3.1 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CCF43088.1 - 0.0036 17.3 0.0 0.0072 16.4 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) TMP-TENI PF02581.17 CCF43089.1 - 2.1e-07 30.5 0.0 2.2e-07 30.4 0.0 1.0 1 0 0 1 1 1 1 Thiamine monophosphate synthase PGP_phosphatase PF09419.10 CCF43089.1 - 0.17 11.5 0.1 0.18 11.4 0.1 1.1 1 0 0 1 1 1 0 Mitochondrial PGP phosphatase Fungal_trans PF04082.18 CCF43090.1 - 0.00021 20.4 0.0 0.00041 19.5 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Methyltransf_23 PF13489.6 CCF43091.1 - 7.8e-19 68.1 0.0 1.2e-18 67.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF43091.1 - 1.9e-14 54.1 0.0 5e-14 52.8 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF43091.1 - 1.2e-13 51.5 0.0 2.3e-13 50.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF43091.1 - 8.1e-09 35.4 0.0 1.7e-07 31.2 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF43091.1 - 7.9e-08 33.0 0.0 4.7e-07 30.5 0.0 2.3 2 1 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCF43091.1 - 1.2e-05 24.7 0.0 7.3e-05 22.2 0.0 1.9 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 CCF43091.1 - 0.0014 18.2 0.0 0.0067 15.9 0.0 2.0 2 0 0 2 2 2 1 Putative methyltransferase CMAS PF02353.20 CCF43091.1 - 0.0034 16.7 0.0 0.0056 16.0 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase MTS PF05175.14 CCF43091.1 - 0.0099 15.4 0.0 0.065 12.8 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase small domain FtsJ PF01728.19 CCF43091.1 - 0.012 15.8 0.0 0.028 14.5 0.0 1.6 2 0 0 2 2 2 0 FtsJ-like methyltransferase Methyltransf_2 PF00891.18 CCF43091.1 - 0.012 14.9 0.0 0.019 14.3 0.0 1.2 1 0 0 1 1 1 0 O-methyltransferase domain PrmA PF06325.13 CCF43091.1 - 0.024 14.0 0.0 0.038 13.4 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_16 PF10294.9 CCF43091.1 - 0.18 11.5 0.0 0.28 10.9 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase Lysine_decarbox PF03641.14 CCF43092.1 - 1.1e-29 103.2 0.0 1.6e-29 102.6 0.0 1.3 1 0 0 1 1 1 1 Possible lysine decarboxylase LDcluster4 PF18306.1 CCF43092.1 - 5.3e-05 22.9 1.4 5.3e-05 22.9 1.4 2.4 2 1 0 2 2 2 1 SLOG cluster4 family IMD PF08397.11 CCF43094.1 - 0.00036 20.0 2.5 0.056 12.8 2.5 2.1 1 1 0 1 1 1 1 IRSp53/MIM homology domain PetM PF08041.11 CCF43095.1 - 1 9.0 5.5 0.62 9.7 0.7 2.8 2 0 0 2 2 2 0 PetM family of cytochrome b6f complex subunit 7 MFS_1 PF07690.16 CCF43096.1 - 6.3e-12 45.1 49.5 6.3e-12 45.1 49.5 2.8 1 1 2 3 3 3 2 Major Facilitator Superfamily Corona_M PF01635.18 CCF43096.1 - 0.073 12.4 1.0 0.23 10.8 1.0 1.7 1 1 0 1 1 1 0 Coronavirus M matrix/glycoprotein PQ-loop PF04193.14 CCF43097.1 - 4.8e-41 138.3 8.5 4.8e-20 71.1 1.6 2.6 2 0 0 2 2 2 2 PQ loop repeat COX1 PF00115.20 CCF43097.1 - 0.03 13.2 0.2 0.03 13.2 0.2 1.8 2 0 0 2 2 2 0 Cytochrome C and Quinol oxidase polypeptide I MtN3_slv PF03083.16 CCF43097.1 - 0.19 11.8 0.2 0.19 11.8 0.2 2.4 2 1 0 2 2 2 0 Sugar efflux transporter for intercellular exchange NMN_transporter PF04973.12 CCF43097.1 - 9 6.2 10.3 3.5 7.6 3.3 2.8 2 1 0 2 2 2 0 Nicotinamide mononucleotide transporter NUDIX PF00293.28 CCF43098.1 - 1.7e-15 57.2 0.0 4e-15 56.0 0.0 1.6 1 0 0 1 1 1 1 NUDIX domain NUDIX-like PF09296.11 CCF43098.1 - 2.1e-14 54.0 0.0 4.7e-14 52.9 0.0 1.6 1 0 0 1 1 1 1 NADH pyrophosphatase-like rudimentary NUDIX domain zf-NADH-PPase PF09297.11 CCF43098.1 - 2e-05 24.2 1.0 3.3e-05 23.5 1.0 1.4 1 0 0 1 1 1 1 NADH pyrophosphatase zinc ribbon domain Arf PF00025.21 CCF43099.1 - 1.2e-38 132.3 0.0 2.1e-38 131.5 0.0 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 CCF43099.1 - 1.4e-14 54.0 0.0 1.4e-09 37.6 0.0 2.0 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.13 CCF43099.1 - 1.3e-09 38.3 0.0 2.9e-09 37.2 0.0 1.6 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 CCF43099.1 - 2.1e-08 33.9 0.0 5.6e-08 32.6 0.0 1.6 1 1 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 CCF43099.1 - 6e-08 32.3 0.0 7.2e-08 32.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 CCF43099.1 - 3e-07 30.0 0.0 7.2e-07 28.8 0.0 1.5 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 CCF43099.1 - 0.00033 20.7 0.0 0.00049 20.2 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CCF43099.1 - 0.00063 19.3 0.0 0.0023 17.5 0.0 1.8 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain NACHT PF05729.12 CCF43099.1 - 0.1 12.5 0.0 0.22 11.4 0.0 1.5 1 1 0 1 1 1 0 NACHT domain RNase_PH PF01138.21 CCF43100.1 - 3.5e-22 79.3 0.0 5.8e-22 78.6 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 CCF43100.1 - 4.8e-08 32.9 0.0 8.3e-08 32.2 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Cwf_Cwc_15 PF04889.12 CCF43101.1 - 7e-87 291.2 22.6 7.9e-87 291.1 22.6 1.0 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein CDC27 PF09507.10 CCF43101.1 - 0.01 15.3 14.5 0.012 15.0 14.5 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 YL1 PF05764.13 CCF43101.1 - 0.013 15.6 22.6 0.016 15.3 22.6 1.3 1 0 0 1 1 1 0 YL1 nuclear protein Nop14 PF04147.12 CCF43101.1 - 0.23 9.6 24.0 0.26 9.5 24.0 1.1 1 0 0 1 1 1 0 Nop14-like family SGT1 PF07093.11 CCF43101.1 - 0.27 9.6 9.6 0.34 9.3 9.6 1.1 1 0 0 1 1 1 0 SGT1 protein CDC45 PF02724.14 CCF43101.1 - 0.46 8.7 20.8 0.55 8.5 20.8 1.1 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 CCF43101.1 - 0.72 9.2 26.2 0.85 9.0 26.2 1.1 1 0 0 1 1 1 0 SDA1 AAA_11 PF13086.6 CCF43101.1 - 1.5 8.5 5.7 1.8 8.3 5.7 1.2 1 0 0 1 1 1 0 AAA domain DUF3381 PF11861.8 CCF43101.1 - 2.5 7.9 21.2 4.8 7.0 21.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) RR_TM4-6 PF06459.12 CCF43101.1 - 3.6 7.3 11.4 5 6.9 11.4 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Hid1 PF12722.7 CCF43101.1 - 6.4 4.8 6.5 7 4.6 6.5 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Presenilin PF01080.17 CCF43101.1 - 7.1 5.3 8.8 8.8 5.0 8.8 1.1 1 0 0 1 1 1 0 Presenilin SAPS PF04499.15 CCF43101.1 - 8.3 5.1 9.8 8.9 5.0 9.8 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein SRF-TF PF00319.18 CCF43104.1 - 5.9e-21 73.7 0.1 8.2e-21 73.2 0.1 1.2 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) CDC45 PF02724.14 CCF43104.1 - 0.16 10.2 0.6 0.2 9.9 0.6 1.1 1 0 0 1 1 1 0 CDC45-like protein MRI PF15325.6 CCF43104.1 - 1.9 9.6 4.4 1 10.5 0.5 2.1 2 0 0 2 2 2 0 Modulator of retrovirus infection LRS4 PF10422.9 CCF43105.1 - 1.8e-05 24.4 3.0 2.4e-05 24.0 3.0 1.1 1 0 0 1 1 1 1 Monopolin complex subunit LRS4 Pox_Ag35 PF03286.14 CCF43105.1 - 0.05 13.4 3.9 0.075 12.8 3.9 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Nucleo_P87 PF07267.11 CCF43105.1 - 0.11 11.3 0.9 0.14 11.0 0.9 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 ASFV_J13L PF05568.11 CCF43105.1 - 0.38 10.5 3.3 0.47 10.2 3.3 1.1 1 0 0 1 1 1 0 African swine fever virus J13L protein zf-CCHC PF00098.23 CCF43107.1 - 5.3e-20 70.5 32.6 6e-07 29.2 1.4 4.2 4 0 0 4 4 4 4 Zinc knuckle zf-CCHC_2 PF13696.6 CCF43107.1 - 1.4e-08 34.4 27.2 0.0011 18.7 1.9 4.3 4 0 0 4 4 4 4 Zinc knuckle zf-CCHC_4 PF14392.6 CCF43107.1 - 0.00033 20.3 19.3 0.012 15.3 0.4 4.2 4 0 0 4 4 4 4 Zinc knuckle zf-CCHC_3 PF13917.6 CCF43107.1 - 0.084 12.9 21.4 3.9 7.5 2.0 4.3 1 1 3 4 4 4 0 Zinc knuckle zf-C2H2_10 PF16588.5 CCF43107.1 - 4 7.3 28.6 3.3 7.5 1.0 4.2 4 0 0 4 4 4 0 C2H2 zinc-finger GFA PF04828.14 CCF43108.1 - 0.0057 17.0 0.0 0.011 16.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme Trp_oprn_chp PF09534.10 CCF43109.1 - 0.0014 18.5 0.6 0.0023 17.8 0.6 1.4 1 1 0 1 1 1 1 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Na_H_antiport_1 PF06965.12 CCF43109.1 - 0.028 13.3 0.0 0.033 13.1 0.0 1.0 1 0 0 1 1 1 0 Na+/H+ antiporter 1 DUF4690 PF15756.5 CCF43109.1 - 0.085 13.5 1.0 0.14 12.8 0.7 1.4 1 1 0 1 1 1 0 Small Novel Rich in Cartilage DUF2407_C PF13373.6 CCF43109.1 - 0.15 12.3 0.0 0.21 11.7 0.0 1.3 1 0 0 1 1 1 0 DUF2407 C-terminal domain Comm PF15957.5 CCF43109.1 - 0.17 12.2 0.0 0.24 11.8 0.0 1.2 1 0 0 1 1 1 0 Commissureless PT PF04886.12 CCF43110.1 - 2 8.0 13.4 0.25 10.9 5.0 2.8 2 2 0 2 2 2 0 PT repeat AT_hook PF02178.19 CCF43112.1 - 0.027 14.3 1.7 0.062 13.2 1.7 1.7 1 0 0 1 1 1 0 AT hook motif Presenilin PF01080.17 CCF43112.1 - 0.63 8.7 2.2 0.82 8.4 2.2 1.2 1 0 0 1 1 1 0 Presenilin NCKAP5 PF15246.6 CCF43113.1 - 0.026 14.2 1.1 0.028 14.0 1.1 1.0 1 0 0 1 1 1 0 Nck-associated protein 5, Peripheral clock protein Sugar_tr PF00083.24 CCF43114.1 - 5.4e-78 262.9 19.0 6.1e-78 262.7 19.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF43114.1 - 4.2e-13 48.9 19.8 4.2e-13 48.9 19.8 2.2 1 1 1 2 2 2 1 Major Facilitator Superfamily DUF4118 PF13493.6 CCF43114.1 - 1 9.1 14.2 2 8.3 1.3 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4118) MFS_1 PF07690.16 CCF43117.1 - 7e-32 110.7 30.5 7e-32 110.7 30.5 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF43117.1 - 1.6e-13 50.3 10.3 1.6e-13 50.3 10.3 3.1 2 1 1 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.13 CCF43117.1 - 0.00064 18.3 4.5 0.00064 18.3 4.5 1.9 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) DUF4267 PF14087.6 CCF43118.1 - 1.6e-20 73.2 3.6 2.3e-20 72.7 3.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4267) DUF456 PF04306.13 CCF43118.1 - 0.41 10.9 8.1 0.028 14.7 3.3 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF456) PNP_UDP_1 PF01048.20 CCF43120.1 - 2.3e-09 36.9 0.0 5.3e-09 35.7 0.0 1.6 1 1 0 1 1 1 1 Phosphorylase superfamily NACHT PF05729.12 CCF43120.1 - 1.4e-06 28.4 0.1 2.9e-06 27.3 0.1 1.5 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 CCF43120.1 - 0.0002 21.7 0.0 0.00041 20.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CCF43120.1 - 0.00064 20.1 0.0 0.0021 18.5 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain KAP_NTPase PF07693.14 CCF43120.1 - 0.0031 16.8 1.5 0.77 8.9 0.1 2.2 2 0 0 2 2 2 2 KAP family P-loop domain AFG1_ATPase PF03969.16 CCF43120.1 - 0.071 12.0 0.2 0.38 9.6 0.1 1.9 2 0 0 2 2 2 0 AFG1-like ATPase Mito_fiss_reg PF05308.11 CCF43120.1 - 0.073 13.1 1.1 0.13 12.3 1.1 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator AAA_30 PF13604.6 CCF43120.1 - 0.13 12.0 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CCF43120.1 - 0.17 12.4 0.1 0.41 11.2 0.1 1.6 1 0 0 1 1 1 0 ABC transporter AAA_29 PF13555.6 CCF43120.1 - 0.18 11.5 0.0 0.41 10.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain CAP_N PF01213.19 CCF43120.1 - 0.56 9.6 1.9 0.95 8.9 1.9 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal PRIMA1 PF16101.5 CCF43120.1 - 2.1 8.4 4.1 4.1 7.5 4.1 1.4 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 UFD1 PF03152.14 CCF43122.1 - 2.9e-25 88.7 0.0 6.3e-25 87.6 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 ELO PF01151.18 CCF43123.1 - 5.3e-82 275.1 12.0 6.5e-82 274.8 12.0 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family O-FucT PF10250.9 CCF43124.1 - 5.2e-09 36.3 0.0 9.6e-09 35.4 0.0 1.4 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase TPR_8 PF13181.6 CCF43125.1 - 8.9e-06 25.5 0.3 5.4e-05 23.1 0.1 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 CCF43125.1 - 0.00018 21.2 0.4 0.0042 16.8 0.1 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 CCF43125.1 - 0.00042 20.2 0.9 0.0016 18.4 0.1 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 CCF43125.1 - 0.0026 18.0 0.1 0.009 16.3 0.1 2.0 1 0 0 1 1 1 1 Tetratricopeptide repeat Gemin6 PF06372.12 CCF43125.1 - 0.0044 16.6 0.1 0.88 9.1 0.0 2.3 2 0 0 2 2 2 2 Gemin6 protein DUF2656 PF10847.8 CCF43125.1 - 0.019 15.0 0.0 0.039 14.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2656) TPR_19 PF14559.6 CCF43125.1 - 0.02 15.4 1.6 0.11 13.0 0.2 2.8 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 CCF43125.1 - 0.029 14.4 0.1 0.24 11.5 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 CCF43125.1 - 0.34 11.7 1.8 16 6.4 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 CCF43125.1 - 0.69 9.9 0.0 0.69 9.9 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat AMP-binding PF00501.28 CCF43126.1 - 1.8e-41 142.2 0.0 2e-41 142.0 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AAA_23 PF13476.6 CCF43127.1 - 1.1e-15 58.7 38.5 1.1e-09 39.1 31.3 4.2 2 1 0 2 2 2 2 AAA domain SMC_N PF02463.19 CCF43127.1 - 1.4e-12 47.5 6.8 1.4e-12 47.5 6.8 1.6 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 CCF43127.1 - 1.5e-09 38.0 0.0 2.1e-08 34.3 0.0 2.3 2 1 0 2 2 2 1 AAA ATPase domain AAA_21 PF13304.6 CCF43127.1 - 0.0018 18.1 0.4 0.015 15.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CCF43127.1 - 0.0094 15.7 0.0 0.019 14.7 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA PF00004.29 CCF43127.1 - 0.012 16.1 0.1 0.21 12.0 0.0 2.7 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Tubulin-binding PF00418.19 CCF43127.1 - 0.1 12.6 0.1 0.31 11.1 0.1 1.7 1 0 0 1 1 1 0 Tau and MAP protein, tubulin-binding repeat AAA_27 PF13514.6 CCF43127.1 - 0.22 11.1 0.0 0.22 11.1 0.0 4.1 3 1 1 5 5 5 0 AAA domain Use1 PF09753.9 CCF43128.1 - 0.023 14.4 0.1 0.026 14.2 0.1 1.0 1 0 0 1 1 1 0 Membrane fusion protein Use1 Apc15p PF05841.11 CCF43129.1 - 8.4e-27 94.4 6.0 1.3e-26 93.8 6.0 1.3 1 0 0 1 1 1 1 Apc15p protein DUF4148 PF13663.6 CCF43129.1 - 0.85 9.8 3.5 2.9 8.2 3.5 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4148) Abhydrolase_3 PF07859.13 CCF43130.1 - 1.4e-21 77.4 0.1 2e-21 76.8 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 CCF43130.1 - 1.2e-14 53.9 0.0 1.7e-14 53.5 0.0 1.1 1 0 0 1 1 1 1 Steryl acetyl hydrolase adh_short PF00106.25 CCF43131.1 - 4.9e-35 120.8 0.0 7e-35 120.3 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF43131.1 - 4.8e-20 72.1 0.0 7.4e-20 71.5 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF43131.1 - 2.1e-06 27.8 0.0 2.5e-05 24.3 0.0 2.3 1 1 0 1 1 1 1 KR domain DUF1776 PF08643.10 CCF43131.1 - 1.9e-05 24.2 0.0 3.6e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Epimerase PF01370.21 CCF43131.1 - 0.0041 16.6 0.0 0.0061 16.1 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CCF43131.1 - 0.021 13.8 0.0 0.03 13.3 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_8 PF13450.6 CCF43132.1 - 6.4e-07 29.5 0.0 1.6e-06 28.2 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FMO-like PF00743.19 CCF43132.1 - 5.5e-06 25.1 0.0 8.5e-06 24.5 0.0 1.3 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like K_oxygenase PF13434.6 CCF43132.1 - 0.00011 21.5 0.0 0.018 14.2 0.0 2.9 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 CCF43132.1 - 0.042 13.1 0.0 1.4 8.1 0.0 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Fungal_trans PF04082.18 CCF43133.1 - 3e-17 62.5 0.0 1e-16 60.8 0.0 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain DUF1195 PF06708.11 CCF43133.1 - 0.092 12.5 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1195) p450 PF00067.22 CCF43134.1 - 1.5e-53 182.2 0.0 2e-53 181.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Atg8 PF02991.16 CCF43135.1 - 3.4e-36 123.6 3.4 4.8e-33 113.4 0.2 2.1 2 0 0 2 2 2 2 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 CCF43135.1 - 0.00083 19.7 0.0 0.0012 19.3 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Glyco_hydro_61 PF03443.14 CCF43136.1 - 1e-38 133.4 0.0 1.2e-38 133.1 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 SnoaL PF07366.12 CCF43137.1 - 0.00047 20.0 0.1 0.00069 19.4 0.1 1.2 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase SnoaL_2 PF12680.7 CCF43137.1 - 0.0006 20.4 0.8 0.00088 19.9 0.3 1.6 2 0 0 2 2 2 1 SnoaL-like domain Cyto_heme_lyase PF01265.17 CCF43139.1 - 5e-14 52.6 24.0 3.9e-13 49.7 15.2 3.0 1 1 1 2 2 2 2 Cytochrome c/c1 heme lyase BLM10_mid PF16507.5 CCF43140.1 - 5.2e-157 523.7 0.0 8.2e-157 523.0 0.0 1.3 1 0 0 1 1 1 1 Proteasome-substrate-size regulator, mid region BLM10_N PF16547.5 CCF43140.1 - 1.9e-21 76.1 0.0 5.9e-21 74.5 0.0 1.9 1 0 0 1 1 1 1 Proteasome-substrate-size regulator, N-terminal Mito_carr PF00153.27 CCF43141.1 - 4.6e-56 186.7 2.4 2.5e-18 65.8 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DOPA_dioxygen PF08883.11 CCF43142.1 - 5.2e-31 107.0 0.0 6.7e-31 106.6 0.0 1.1 1 0 0 1 1 1 1 Dopa 4,5-dioxygenase family IMS PF00817.20 CCF43143.1 - 1.9e-37 128.6 0.0 4.1e-37 127.5 0.0 1.5 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 CCF43143.1 - 4.1e-13 50.1 0.0 7.2e-13 49.3 0.0 1.4 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 CCF43143.1 - 0.057 13.8 0.0 0.16 12.3 0.0 1.7 1 0 0 1 1 1 0 IMS family HHH motif Sugar_tr PF00083.24 CCF43144.1 - 1.3e-67 228.7 25.0 8.1e-61 206.2 19.0 2.0 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 CCF43144.1 - 1.4e-24 86.7 32.7 2.5e-24 85.9 30.1 1.9 2 0 0 2 2 2 1 Major Facilitator Superfamily CoaE PF01121.20 CCF43144.1 - 0.025 14.3 0.0 0.035 13.8 0.0 1.2 1 0 0 1 1 1 0 Dephospho-CoA kinase OATP PF03137.20 CCF43144.1 - 0.19 10.0 8.8 0.085 11.1 5.3 2.2 1 1 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family VPS13_mid_rpt PF16910.5 CCF43146.1 - 7.9e-92 306.9 21.6 8.7e-90 300.3 1.5 6.2 6 1 1 7 7 7 2 Repeating coiled region of VPS13 VPS13 PF16908.5 CCF43146.1 - 4.3e-87 291.8 0.3 2.7e-83 279.4 0.0 3.6 3 0 0 3 3 3 3 Vacuolar sorting-associated protein 13, N-terminal Chorein_N PF12624.7 CCF43146.1 - 1.2e-40 138.2 0.0 5.2e-40 136.2 0.0 2.2 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 DUF3429 PF11911.8 CCF43147.1 - 6.3e-45 153.0 7.1 8.7e-45 152.5 7.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3429) Egh16-like PF11327.8 CCF43148.1 - 3.3e-27 96.1 8.5 3.3e-27 96.1 8.5 1.9 2 1 0 2 2 2 1 Egh16-like virulence factor V-set PF07686.17 CCF43148.1 - 0.022 14.9 0.1 0.058 13.6 0.1 1.7 1 0 0 1 1 1 0 Immunoglobulin V-set domain Izumo-Ig PF16706.5 CCF43148.1 - 0.075 13.1 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Izumo-like Immunoglobulin domain DUF4307 PF14155.6 CCF43148.1 - 0.11 12.3 1.0 0.36 10.7 0.8 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4307) MSA-2c PF12238.8 CCF43148.1 - 1.5 8.7 7.0 2.2 8.2 7.0 1.3 1 0 0 1 1 1 0 Merozoite surface antigen 2c But2 PF09792.9 CCF43149.1 - 6.5e-38 130.3 0.6 6.5e-38 130.3 0.6 1.7 2 1 1 3 3 3 1 Ubiquitin 3 binding protein But2 C-terminal domain ZT_dimer PF16916.5 CCF43150.1 - 1.3e-05 25.2 0.1 1.8e-05 24.7 0.1 1.3 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter DAPDH_C PF16654.5 CCF43150.1 - 0.085 12.7 0.1 0.21 11.4 0.0 1.6 1 1 1 2 2 2 0 Diaminopimelic acid dehydrogenase C-terminal domain FGGY_N PF00370.21 CCF43151.1 - 7.7e-19 68.2 0.0 1.3e-10 41.3 0.0 2.2 2 0 0 2 2 2 2 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 CCF43151.1 - 1.6e-07 31.3 0.0 3.2e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain SRP-alpha_N PF04086.13 CCF43151.1 - 0.00099 19.1 0.1 0.0017 18.4 0.1 1.3 1 0 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal WH1 PF00568.23 CCF43153.1 - 5.9e-18 64.8 0.1 7.2e-18 64.6 0.1 1.1 1 0 0 1 1 1 1 WH1 domain Esterase_phd PF10503.9 CCF43154.1 - 3e-21 75.9 0.8 4.1e-21 75.5 0.8 1.2 1 0 0 1 1 1 1 Esterase PHB depolymerase Peptidase_S9 PF00326.21 CCF43154.1 - 2.4e-08 33.7 0.1 4.8e-08 32.7 0.1 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family Esterase PF00756.20 CCF43154.1 - 0.0032 17.1 0.1 0.0037 16.9 0.1 1.2 1 0 0 1 1 1 1 Putative esterase COesterase PF00135.28 CCF43154.1 - 0.0049 15.8 0.0 0.0071 15.3 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_2 PF02230.16 CCF43154.1 - 0.0079 16.0 0.0 1 9.1 0.0 2.3 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase Abhydrolase_3 PF07859.13 CCF43154.1 - 0.019 14.8 0.1 0.026 14.4 0.1 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold LIP PF03583.14 CCF43154.1 - 0.048 13.0 0.4 3.3 7.0 0.0 2.1 2 0 0 2 2 2 0 Secretory lipase Hydrolase_4 PF12146.8 CCF43154.1 - 0.071 12.4 0.1 11 5.2 0.1 2.9 2 1 1 3 3 3 0 Serine aminopeptidase, S33 Fungal_trans PF04082.18 CCF43155.1 - 2.7e-13 49.6 0.0 5.2e-13 48.6 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain P63C PF10546.9 CCF43155.1 - 0.038 14.6 1.5 0.16 12.6 0.3 2.5 1 1 2 3 3 3 0 P63C domain Cpn60_TCP1 PF00118.24 CCF43156.1 - 1.3e-143 479.2 10.4 1.5e-143 479.0 10.4 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF5442 PF17514.2 CCF43156.1 - 0.037 14.2 0.2 0.084 13.1 0.2 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5442) CRM1_repeat PF18777.1 CCF43156.1 - 0.1 12.2 0.0 0.2 11.2 0.0 1.4 1 0 0 1 1 1 0 Chromosome region maintenance or exportin repeat FumaraseC_C PF10415.9 CCF43157.1 - 7.1e-23 80.8 0.0 8.6e-23 80.5 0.0 1.1 1 0 0 1 1 1 1 Fumarase C C-terminus CdhC PF03598.15 CCF43157.1 - 0.18 11.7 0.0 0.25 11.2 0.0 1.2 1 0 0 1 1 1 0 CO dehydrogenase/acetyl-CoA synthase complex beta subunit Metallophos PF00149.28 CCF43158.1 - 4.6e-13 50.1 0.0 8.3e-13 49.3 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CCF43158.1 - 1.8e-05 25.0 0.1 0.00039 20.6 0.1 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Zip PF02535.22 CCF43160.1 - 3.2e-32 112.1 8.7 3.7e-22 79.0 7.0 2.1 2 0 0 2 2 2 2 ZIP Zinc transporter Corona_nucleoca PF00937.18 CCF43160.1 - 3.8 6.5 5.6 6.4 5.7 5.6 1.3 1 1 0 1 1 1 0 Coronavirus nucleocapsid protein WSC PF01822.19 CCF43161.1 - 1.5e-14 54.0 6.1 1.5e-14 54.0 6.1 1.7 2 0 0 2 2 2 1 WSC domain Guanylate_cyc PF00211.20 CCF43161.1 - 0.14 11.8 0.1 0.21 11.2 0.1 1.2 1 0 0 1 1 1 0 Adenylate and Guanylate cyclase catalytic domain Metallophos PF00149.28 CCF43162.1 - 8e-12 46.1 0.4 1.4e-11 45.3 0.4 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CCF43162.1 - 0.00012 22.3 0.9 0.00045 20.4 0.9 1.9 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Anoctamin PF04547.12 CCF43163.1 - 2.9e-115 385.7 9.3 3.5e-115 385.4 9.3 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel SH3_9 PF14604.6 CCF43164.1 - 1e-09 38.1 1.1 1.7e-09 37.4 0.1 1.9 2 0 0 2 2 2 1 Variant SH3 domain Cyt-b5 PF00173.28 CCF43165.1 - 6.1e-23 80.8 0.1 1.1e-22 80.0 0.1 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Sortilin-Vps10 PF15902.5 CCF43166.1 - 8.1e-159 529.2 11.2 7.3e-145 483.2 4.9 2.1 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 CCF43166.1 - 1.2e-49 168.9 9.2 2.2e-49 168.1 9.2 1.5 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 CCF43166.1 - 5e-12 43.9 19.1 0.21 11.7 0.1 7.6 6 0 0 6 6 6 5 BNR/Asp-box repeat PSII_BNR PF14870.6 CCF43166.1 - 1.6e-05 24.3 1.1 0.042 13.1 0.0 4.1 3 1 1 4 4 4 1 Photosynthesis system II assembly factor YCF48 BNR_2 PF13088.6 CCF43166.1 - 3.4e-05 23.3 0.6 0.28 10.4 0.0 4.1 4 1 1 5 5 5 2 BNR repeat-like domain CHB_HEX_C PF03174.13 CCF43166.1 - 0.088 12.8 0.2 4.3 7.4 0.0 3.2 3 0 0 3 3 3 0 Chitobiase/beta-hexosaminidase C-terminal domain BNR_6 PF15899.5 CCF43166.1 - 1.2 9.4 15.0 51 4.3 0.2 5.8 6 0 0 6 6 6 0 BNR-Asp box repeat Mago-bind PF09282.10 CCF43167.1 - 6.8e-14 51.4 3.5 1.2e-13 50.6 3.5 1.5 1 0 0 1 1 1 1 Mago binding Spore_coat_CotO PF14153.6 CCF43167.1 - 0.059 13.3 7.0 0.076 12.9 7.0 1.3 1 0 0 1 1 1 0 Spore coat protein CotO Nucleo_P87 PF07267.11 CCF43167.1 - 1.1 8.0 5.7 1.2 7.9 5.7 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 RR_TM4-6 PF06459.12 CCF43167.1 - 1.8 8.3 9.3 2.4 7.9 9.3 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 CCF43167.1 - 4.6 5.9 5.4 5.3 5.7 5.4 1.1 1 0 0 1 1 1 0 Presenilin Cation_ATPase_C PF00689.21 CCF43169.1 - 7e-47 159.5 2.1 7e-47 159.5 2.1 2.7 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 CCF43169.1 - 3e-38 131.2 0.7 3e-38 131.2 0.7 2.7 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase PF13246.6 CCF43169.1 - 2.9e-23 81.7 0.0 8e-23 80.3 0.0 1.8 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 CCF43169.1 - 1.2e-19 71.4 0.0 3.2e-19 70.1 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 CCF43169.1 - 3.3e-08 33.1 0.5 3.2e-07 29.9 0.0 2.7 3 0 0 3 3 3 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 CCF43169.1 - 6.3e-06 26.1 0.5 0.00038 20.3 0.5 2.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 CCF43169.1 - 0.06 13.7 0.0 0.13 12.6 0.0 1.6 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase TctB PF07331.11 CCF43169.1 - 4.2 7.7 10.6 0.92 9.8 0.4 3.4 3 0 0 3 3 3 0 Tripartite tricarboxylate transporter TctB family UCR_UQCRX_QCR9 PF05365.12 CCF43170.1 - 1.5e-19 69.6 0.8 1.7e-19 69.5 0.8 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like Ribonuc_L-PSP PF01042.21 CCF43171.1 - 1.9e-40 137.6 0.0 2.6e-40 137.2 0.0 1.1 1 0 0 1 1 1 1 Endoribonuclease L-PSP PMT PF02366.18 CCF43172.1 - 3.4e-85 285.6 17.8 5.8e-85 284.8 17.8 1.4 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 CCF43172.1 - 3.3e-70 235.8 4.7 3.3e-70 235.8 4.7 2.9 3 1 1 4 4 4 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 CCF43172.1 - 1.1e-19 71.0 0.4 2.9e-19 69.7 0.1 1.7 1 1 1 2 2 2 2 MIR domain RAMP4 PF06624.12 CCF43172.1 - 0.14 12.3 0.2 0.96 9.6 0.1 2.4 3 0 0 3 3 3 0 Ribosome associated membrane protein RAMP4 DUF334 PF03904.13 CCF43172.1 - 1.6 8.2 2.7 0.67 9.5 0.2 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF334) CAP59_mtransfer PF11735.8 CCF43173.1 - 9e-84 280.9 0.0 1.1e-83 280.7 0.0 1.1 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 Abhydrolase_3 PF07859.13 CCF43174.1 - 3.3e-10 40.2 0.0 4e-10 39.9 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Pkinase PF00069.25 CCF43175.1 - 0.00038 19.9 0.0 0.00096 18.6 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF43175.1 - 0.14 11.5 1.0 0.84 8.9 1.0 1.9 1 1 0 1 1 1 0 Protein tyrosine kinase AF-4 PF05110.13 CCF43176.1 - 0.3 9.1 4.0 0.34 8.9 4.0 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein TAF4 PF05236.14 CCF43176.1 - 1.9 8.2 10.8 1.9 8.2 10.8 1.0 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family Mito_carr PF00153.27 CCF43178.1 - 6.2e-51 170.3 5.9 8.8e-17 60.8 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Frag1 PF10277.9 CCF43178.1 - 0.034 13.7 0.0 0.053 13.1 0.0 1.4 1 0 0 1 1 1 0 Frag1/DRAM/Sfk1 family UcrQ PF02939.16 CCF43178.1 - 0.083 12.8 0.1 0.24 11.3 0.1 1.9 1 0 0 1 1 1 0 UcrQ family Fungal_trans PF04082.18 CCF43180.1 - 2.4e-29 102.2 0.0 5.3e-29 101.1 0.0 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF43180.1 - 2.9e-09 36.9 7.6 4.8e-09 36.2 7.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Tropomyosin PF00261.20 CCF43181.1 - 0.013 14.8 29.2 0.038 13.4 4.8 2.5 1 1 1 2 2 2 0 Tropomyosin DivIVA PF05103.13 CCF43181.1 - 0.016 15.3 24.9 0.27 11.3 4.8 4.1 2 1 2 4 4 4 0 DivIVA protein Tropomyosin_1 PF12718.7 CCF43181.1 - 0.05 13.8 29.2 0.54 10.4 15.6 2.7 1 1 1 2 2 2 0 Tropomyosin like Fib_alpha PF08702.10 CCF43181.1 - 0.53 10.5 17.0 0.19 11.9 4.9 3.3 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family LST1 PF05083.13 CCF43181.1 - 0.78 10.1 2.8 2.1 8.7 0.2 2.6 2 0 0 2 2 2 0 LST-1 protein AAA_13 PF13166.6 CCF43181.1 - 2.1 6.9 12.2 3.4 6.2 12.2 1.3 1 0 0 1 1 1 0 AAA domain SHE3 PF17078.5 CCF43181.1 - 8.8 6.0 20.9 0.53 9.9 6.9 2.6 1 1 1 2 2 2 0 SWI5-dependent HO expression protein 3 KASH_CCD PF14662.6 CCF43181.1 - 9.2 6.0 30.3 0.23 11.3 14.6 3.0 2 1 1 3 3 3 0 Coiled-coil region of CCDC155 or KASH Myb_DNA-binding PF00249.31 CCF43182.1 - 4e-23 81.3 0.9 2.7e-13 49.9 0.0 2.2 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CCF43182.1 - 1.6e-16 60.3 1.2 4.1e-13 49.4 0.0 2.2 1 1 1 2 2 2 2 Myb-like DNA-binding domain DUF2774 PF11242.8 CCF43182.1 - 0.021 15.0 0.0 0.19 11.9 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2774) HTH_23 PF13384.6 CCF43182.1 - 0.11 12.3 0.4 0.45 10.4 0.3 2.0 2 0 0 2 2 2 0 Homeodomain-like domain Pkinase PF00069.25 CCF43183.1 - 3.1e-66 223.4 0.0 3.7e-66 223.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF43183.1 - 2.8e-31 108.7 0.0 3.6e-31 108.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF43183.1 - 8.7e-05 22.0 0.0 0.00027 20.3 0.0 1.7 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 CCF43183.1 - 0.0068 16.4 0.0 0.021 14.8 0.0 1.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 CCF43183.1 - 0.071 12.0 0.0 0.092 11.7 0.0 1.1 1 0 0 1 1 1 0 Haspin like kinase domain Seadorna_VP7 PF07387.11 CCF43183.1 - 0.11 11.6 0.0 0.17 10.9 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Pkinase_fungal PF17667.1 CCF43183.1 - 0.16 10.7 0.0 0.23 10.2 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase ECH_1 PF00378.20 CCF43186.1 - 0.018 14.4 0.0 0.021 14.1 0.0 1.1 1 0 0 1 1 1 0 Enoyl-CoA hydratase/isomerase AMP-binding PF00501.28 CCF43188.1 - 8.6e-73 245.3 0.0 1.3e-72 244.7 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.12 CCF43188.1 - 1.8e-65 220.7 0.0 2.6e-65 220.1 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.21 CCF43188.1 - 4.7e-12 45.9 0.0 1.6e-11 44.1 0.0 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CCF43188.1 - 7.6e-11 41.5 0.0 2.5e-10 39.8 0.0 1.8 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family PP-binding PF00550.25 CCF43188.1 - 7.7e-07 29.4 0.0 2.5e-06 27.8 0.0 2.0 2 0 0 2 2 2 1 Phosphopantetheine attachment site NAD_binding_10 PF13460.6 CCF43188.1 - 4.9e-06 26.6 0.0 0.00013 21.9 0.0 2.8 1 1 0 1 1 1 1 NAD(P)H-binding AMP-binding_C PF13193.6 CCF43188.1 - 0.0036 18.3 0.2 0.17 12.9 0.0 3.5 3 1 1 4 4 4 1 AMP-binding enzyme C-terminal domain Ala_racemase_N PF01168.20 CCF43189.1 - 4.5e-21 75.5 0.4 5.7e-21 75.2 0.4 1.0 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain SASA PF03629.18 CCF43189.1 - 0.11 12.1 0.1 0.58 9.8 0.0 2.1 2 1 1 3 3 3 0 Carbohydrate esterase, sialic acid-specific acetylesterase Abhydrolase_6 PF12697.7 CCF43191.1 - 0.00013 22.6 6.0 0.00026 21.7 6.1 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Thioesterase PF00975.20 CCF43191.1 - 0.0024 18.0 0.0 0.0042 17.2 0.0 1.4 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_1 PF00561.20 CCF43191.1 - 0.022 14.4 0.0 0.054 13.1 0.0 1.6 1 1 1 2 2 2 0 alpha/beta hydrolase fold PhaG_MnhG_YufB PF03334.14 CCF43191.1 - 0.045 14.0 0.0 0.089 13.0 0.0 1.5 1 0 0 1 1 1 0 Na+/H+ antiporter subunit Abhydrolase_5 PF12695.7 CCF43191.1 - 0.14 11.9 0.0 1.6 8.4 0.0 2.1 2 0 0 2 2 2 0 Alpha/beta hydrolase family WSC PF01822.19 CCF43192.1 - 1.9e-10 40.8 8.0 3.8e-10 39.8 8.0 1.5 1 0 0 1 1 1 1 WSC domain SKG6 PF08693.10 CCF43192.1 - 6e-06 25.6 9.8 1.4e-05 24.3 9.8 1.6 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Insulin_TMD PF17870.1 CCF43192.1 - 0.11 12.5 0.2 0.21 11.7 0.2 1.4 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment MGC-24 PF05283.11 CCF43192.1 - 0.15 12.5 0.2 0.15 12.5 0.2 2.2 2 1 1 3 3 3 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Hydantoinase_B PF02538.14 CCF43193.1 - 4.9e-143 477.2 0.0 6.7e-143 476.8 0.0 1.2 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.18 CCF43193.1 - 1.4e-79 267.4 0.1 2e-79 266.9 0.1 1.3 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase Proteasome_A_N PF10584.9 CCF43193.1 - 0.047 13.4 0.0 0.09 12.5 0.0 1.5 1 0 0 1 1 1 0 Proteasome subunit A N-terminal signature CDK2AP PF09806.9 CCF43194.1 - 0.06 13.4 2.3 0.089 12.8 2.3 1.3 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein CdvA PF18822.1 CCF43195.1 - 0.014 15.2 0.2 0.029 14.2 0.2 1.5 1 0 0 1 1 1 0 CdvA-like coiled-coil domain DUF3039 PF11238.8 CCF43195.1 - 0.037 13.8 0.0 0.094 12.5 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3039) IL34 PF15036.6 CCF43195.1 - 0.11 12.6 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 Interleukin 34 TMF_DNA_bd PF12329.8 CCF43195.1 - 0.12 12.4 1.5 0.22 11.6 1.5 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding GP41 PF00517.17 CCF43195.1 - 0.13 12.1 0.1 0.26 11.2 0.1 1.5 1 0 0 1 1 1 0 Retroviral envelope protein PI3K_P85_iSH2 PF16454.5 CCF43195.1 - 0.15 11.6 2.4 4.5 6.9 0.1 2.6 2 1 1 3 3 3 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Glyco_transf_22 PF03901.17 CCF43196.1 - 1e-09 38.2 0.1 1.3e-09 37.9 0.1 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family UPF0121 PF03661.13 CCF43197.1 - 2.1e-17 63.4 5.3 2.6e-17 63.0 5.3 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0121) AA_kinase PF00696.28 CCF43199.1 - 2.8e-08 33.7 0.1 4e-08 33.2 0.1 1.2 1 0 0 1 1 1 1 Amino acid kinase family DUF3328 PF11807.8 CCF43200.1 - 1.6e-44 152.3 0.2 2.4e-44 151.7 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) PseudoU_synth_2 PF00849.22 CCF43201.1 - 2.9e-31 108.7 0.0 4.4e-31 108.1 0.0 1.3 1 0 0 1 1 1 1 RNA pseudouridylate synthase Ub-Mut7C PF14451.6 CCF43201.1 - 0.0017 18.1 0.1 0.0039 17.0 0.1 1.5 1 0 0 1 1 1 1 Mut7-C ubiquitin PAS_4 PF08448.10 CCF43201.1 - 0.053 13.8 0.0 0.18 12.1 0.0 1.9 1 0 0 1 1 1 0 PAS fold 4HBT PF03061.22 CCF43202.1 - 9.7e-09 35.5 0.0 1.4e-08 35.0 0.0 1.3 1 0 0 1 1 1 1 Thioesterase superfamily 4HBT_2 PF13279.6 CCF43202.1 - 0.0012 19.3 0.0 0.0014 19.1 0.0 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily GFO_IDH_MocA PF01408.22 CCF43203.1 - 7.1e-19 68.8 0.0 1.2e-18 68.1 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 CCF43203.1 - 0.028 14.4 0.0 0.05 13.6 0.0 1.4 1 0 0 1 1 1 0 Oxidoreductase family, C-terminal alpha/beta domain MatE PF01554.18 CCF43204.1 - 6.1e-53 178.8 25.5 1.9e-28 99.1 6.9 2.4 3 0 0 3 3 3 2 MatE Polysacc_synt_C PF14667.6 CCF43204.1 - 5.6e-06 26.5 12.6 5.6e-06 26.5 12.6 4.6 3 2 0 3 3 3 2 Polysaccharide biosynthesis C-terminal domain Pkinase PF00069.25 CCF43205.1 - 2e-58 197.8 2.0 1.8e-57 194.7 0.0 2.7 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF43205.1 - 9.6e-27 93.9 0.1 2.4e-20 72.9 0.0 2.5 2 0 0 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 CCF43205.1 - 4.2e-05 22.7 0.5 0.00014 20.9 0.1 1.9 1 1 1 2 2 2 1 Haspin like kinase domain Kdo PF06293.14 CCF43205.1 - 0.00066 19.1 0.0 0.0017 17.7 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 CCF43205.1 - 0.00086 18.7 0.6 0.002 17.5 0.0 1.8 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 CCF43205.1 - 0.0071 16.3 6.2 0.029 14.3 0.3 2.6 2 1 1 3 3 3 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 CCF43205.1 - 0.089 11.8 0.0 0.14 11.2 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 RIO1 PF01163.22 CCF43205.1 - 0.19 11.3 1.7 0.98 9.0 0.0 2.3 2 0 0 2 2 2 0 RIO1 family NPP1 PF05630.11 CCF43207.1 - 1e-52 179.1 0.1 1.4e-44 152.6 0.0 2.0 1 1 1 2 2 2 2 Necrosis inducing protein (NPP1) IBR PF01485.21 CCF43208.1 - 1.9e-21 76.0 44.3 3e-10 40.2 3.8 4.6 3 1 1 4 4 4 3 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.25 CCF43208.1 - 7.8e-07 28.9 38.8 0.00049 19.9 5.9 4.6 3 1 1 4 4 4 3 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CCF43208.1 - 0.00011 22.5 44.0 0.00072 19.8 7.6 4.3 2 1 1 3 3 3 2 Ring finger domain zf-C3HC4_2 PF13923.6 CCF43208.1 - 0.0015 18.3 41.7 0.014 15.2 6.1 5.2 3 1 1 4 4 4 2 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CCF43208.1 - 0.0084 16.1 35.2 0.051 13.6 5.7 3.9 3 1 0 3 3 3 2 RING-type zinc-finger UN_NPL4 PF11543.8 CCF43208.1 - 0.024 15.1 0.0 0.053 14.0 0.0 1.6 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 zf-C3HC4_4 PF15227.6 CCF43208.1 - 4.7 7.5 37.0 0.11 12.6 1.4 5.0 5 1 0 5 5 5 0 zinc finger of C3HC4-type, RING Asp PF00026.23 CCF43209.1 - 1.7e-77 260.9 11.0 2e-77 260.7 11.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCF43209.1 - 1.7e-13 51.2 8.0 9.1e-08 32.5 0.1 2.9 1 1 3 4 4 4 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 CCF43209.1 - 0.006 17.2 2.6 0.2 12.3 1.0 2.8 2 1 0 2 2 2 1 Aspartyl protease CDC37_N PF03234.14 CCF43210.1 - 2.6e-48 164.2 0.5 2.9e-48 164.0 0.5 1.0 1 0 0 1 1 1 1 Cdc37 N terminal kinase binding Metallophos PF00149.28 CCF43211.1 - 9.2e-07 29.6 0.9 2.5e-06 28.1 0.9 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CCF43211.1 - 3.1e-05 24.2 0.0 0.0024 18.1 0.0 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain MMtag PF10159.9 CCF43215.1 - 1.5e-31 108.5 4.0 1.5e-31 108.5 4.0 2.1 2 0 0 2 2 2 1 Multiple myeloma tumor-associated RR_TM4-6 PF06459.12 CCF43215.1 - 0.055 13.3 6.4 0.066 13.0 6.4 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SRRM_C PF15230.6 CCF43215.1 - 1.1 9.9 23.7 0.11 13.1 17.3 2.2 2 0 0 2 2 2 0 Serine/arginine repetitive matrix protein C-terminus U1snRNP70_N PF12220.8 CCF43215.1 - 1.4 9.6 6.1 5.8 7.6 0.7 2.3 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Ribosomal_60s PF00428.19 CCF43215.1 - 1.9 9.1 8.2 3.4 8.3 1.8 2.3 2 0 0 2 2 2 0 60s Acidic ribosomal protein Med6 PF04934.14 CCF43216.1 - 7.1e-37 126.2 0.0 1.1e-36 125.6 0.0 1.3 1 0 0 1 1 1 1 MED6 mediator sub complex component p450 PF00067.22 CCF43218.1 - 7.4e-25 87.6 0.0 9.1e-25 87.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Abhydrolase_6 PF12697.7 CCF43219.1 - 2.4e-20 74.1 4.5 2.8e-20 73.9 4.5 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CCF43219.1 - 1.2e-10 41.5 0.0 2.4e-07 30.7 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CCF43219.1 - 2.1e-10 40.3 0.0 3.8e-10 39.5 0.0 1.3 1 1 0 1 1 1 1 Serine aminopeptidase, S33 PGAP1 PF07819.13 CCF43219.1 - 0.0057 16.4 0.0 0.012 15.3 0.0 1.4 1 0 0 1 1 1 1 PGAP1-like protein UPF0227 PF05728.12 CCF43219.1 - 0.0081 16.1 0.0 0.096 12.6 0.0 2.1 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0227) Thioesterase PF00975.20 CCF43219.1 - 0.016 15.4 0.0 0.054 13.6 0.0 1.8 2 0 0 2 2 2 0 Thioesterase domain DLH PF01738.18 CCF43219.1 - 0.016 14.7 0.0 0.21 11.1 0.0 2.2 2 0 0 2 2 2 0 Dienelactone hydrolase family FSH1 PF03959.13 CCF43219.1 - 0.11 12.1 0.0 0.52 9.9 0.0 1.8 1 1 0 1 1 1 0 Serine hydrolase (FSH1) Ser_hydrolase PF06821.13 CCF43219.1 - 0.12 12.2 0.0 0.3 10.9 0.0 1.6 2 0 0 2 2 2 0 Serine hydrolase Sugar_tr PF00083.24 CCF43220.1 - 4.3e-89 299.5 12.2 4.9e-89 299.3 12.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF43220.1 - 8.6e-22 77.5 15.0 8.6e-22 77.5 15.0 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily Tristanin_u2 PF16638.5 CCF43221.1 - 0.25 12.2 10.3 5.6 7.8 10.3 2.2 1 1 0 1 1 1 0 Unstructured region on methyltransferase between zinc-fingers OPT PF03169.15 CCF43222.1 - 1.3e-37 129.8 23.3 1.5e-37 129.5 23.3 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF2207 PF09972.9 CCF43222.1 - 0.28 9.9 6.2 0.92 8.2 0.3 2.3 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) oligo_HPY PF08352.12 CCF43224.1 - 0.043 14.3 0.0 0.064 13.8 0.0 1.4 1 1 0 1 1 1 0 Oligopeptide/dipeptide transporter, C-terminal region TB PF00683.17 CCF43225.1 - 0.0037 17.0 0.1 0.0053 16.5 0.1 1.2 1 0 0 1 1 1 1 TB domain Glyco_hydro_3_C PF01915.22 CCF43226.1 - 5.9e-36 124.3 0.0 8.3e-36 123.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 CCF43226.1 - 3.3e-28 97.6 0.2 5.8e-28 96.8 0.2 1.4 1 0 0 1 1 1 1 Fibronectin type III-like domain zf-H2C2 PF09337.10 CCF43227.1 - 1e-15 57.7 1.4 1.9e-15 56.8 1.4 1.5 1 0 0 1 1 1 1 H2C2 zinc finger Integrase_H2C2 PF17921.1 CCF43227.1 - 1e-11 44.7 0.1 2.2e-11 43.7 0.1 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain Acetyltransf_4 PF13420.7 CCF43227.1 - 0.00012 22.2 0.0 0.00021 21.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CCF43227.1 - 0.00074 19.7 0.0 0.0014 18.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_3 PF13302.7 CCF43227.1 - 0.035 14.8 0.0 0.07 13.8 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Miff PF05644.11 CCF43227.1 - 1.5 8.4 4.5 2.5 7.7 4.5 1.3 1 0 0 1 1 1 0 Mitochondrial and peroxisomal fission factor Mff adh_short_C2 PF13561.6 CCF43228.1 - 2e-59 201.0 2.1 2.5e-59 200.7 2.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF43228.1 - 1.6e-40 138.7 1.8 2e-40 138.3 1.8 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF43228.1 - 7.9e-05 22.6 0.4 0.00012 22.0 0.4 1.2 1 0 0 1 1 1 1 KR domain Dabb PF07876.12 CCF43229.1 - 1.8e-13 50.9 0.2 2.6e-13 50.4 0.2 1.2 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain DIE2_ALG10 PF04922.12 CCF43230.1 - 5.7e-18 65.4 0.3 5.7e-18 65.4 0.3 1.4 2 0 0 2 2 2 1 DIE2/ALG10 family QCR10 PF09796.9 CCF43231.1 - 1.4e-28 98.7 0.4 1.9e-28 98.3 0.4 1.2 1 0 0 1 1 1 1 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) PASTA PF03793.19 CCF43231.1 - 0.035 14.0 0.0 0.072 13.0 0.0 1.5 1 0 0 1 1 1 0 PASTA domain Med4 PF10018.9 CCF43232.1 - 3.1e-23 82.5 0.7 4.8e-23 81.8 0.5 1.3 2 0 0 2 2 2 1 Vitamin-D-receptor interacting Mediator subunit 4 PspA_IM30 PF04012.12 CCF43232.1 - 0.0017 18.0 3.0 0.0022 17.6 3.0 1.1 1 0 0 1 1 1 1 PspA/IM30 family Exo70 PF03081.15 CCF43232.1 - 0.017 14.2 0.1 0.02 13.9 0.1 1.0 1 0 0 1 1 1 0 Exo70 exocyst complex subunit SQS_PSY PF00494.19 CCF43232.1 - 0.03 13.8 0.4 0.037 13.5 0.4 1.1 1 0 0 1 1 1 0 Squalene/phytoene synthase NIT PF08376.10 CCF43232.1 - 0.032 14.7 4.8 0.05 14.1 4.8 1.4 1 1 0 1 1 1 0 Nitrate and nitrite sensing CHASE6_C PF17150.4 CCF43232.1 - 0.12 13.0 2.2 2.7 8.7 0.1 2.1 1 1 1 2 2 2 0 C-terminal domain of two-partite extracellular sensor domain DUF4763 PF15960.5 CCF43232.1 - 0.36 10.1 3.6 0.43 9.8 2.9 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4763) IQ PF00612.27 CCF43233.1 - 0.014 15.2 0.2 0.072 12.9 0.0 2.3 2 0 0 2 2 2 0 IQ calmodulin-binding motif OATP PF03137.20 CCF43233.1 - 0.017 13.5 1.2 0.032 12.5 0.6 1.7 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Gram_pos_anchor PF00746.21 CCF43238.1 - 0.63 10.0 3.3 8.1 6.5 0.6 2.6 2 0 0 2 2 2 0 LPXTG cell wall anchor motif GMC_oxred_C PF05199.13 CCF43239.1 - 1.1e-10 42.2 0.0 1.6e-10 41.6 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase Methyltransf_3 PF01596.17 CCF43240.1 - 1.2e-21 76.9 0.0 1.6e-21 76.5 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 CCF43240.1 - 1.4e-11 45.4 0.0 2.2e-11 44.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF43240.1 - 7.4e-07 29.8 0.0 1.2e-06 29.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF43240.1 - 2.4e-06 28.1 0.0 3.9e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.10 CCF43240.1 - 0.0018 17.9 0.0 0.0024 17.4 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Cons_hypoth95 PF03602.15 CCF43240.1 - 0.012 15.3 0.0 0.016 14.8 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Methyltransf_23 PF13489.6 CCF43240.1 - 0.063 13.1 0.0 0.079 12.8 0.0 1.3 1 1 0 1 1 1 0 Methyltransferase domain MARVEL PF01284.23 CCF43241.1 - 4.4e-07 30.0 8.3 1.2e-06 28.7 8.3 1.6 1 1 0 1 1 1 1 Membrane-associating domain VIT1 PF01988.19 CCF43241.1 - 0.042 13.7 2.1 0.054 13.3 2.1 1.3 1 0 0 1 1 1 0 VIT family Cyt_c_ox_IV PF12270.8 CCF43241.1 - 0.099 12.8 0.1 0.099 12.8 0.1 2.7 1 1 1 3 3 3 0 Cytochrome c oxidase subunit IV dCMP_cyt_deam_1 PF00383.23 CCF43242.1 - 1.4e-11 44.2 2.7 5.5e-08 32.6 2.7 2.4 1 1 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 CCF43242.1 - 0.00035 20.3 1.0 0.16 11.7 1.8 2.3 1 1 1 2 2 2 2 MafB19-like deaminase zf-CCHC PF00098.23 CCF43242.1 - 0.00038 20.4 0.1 0.00081 19.4 0.1 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_4 PF14392.6 CCF43242.1 - 0.58 9.9 6.0 5.9 6.7 0.4 2.4 2 0 0 2 2 2 0 Zinc knuckle Glyco_hydro_3 PF00933.21 CCF43243.1 - 1.2e-05 24.8 0.0 1.5e-05 24.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Aconitase PF00330.20 CCF43245.1 - 2.5e-135 452.1 0.0 3e-135 451.8 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 CCF43245.1 - 0.00048 20.5 0.0 0.0011 19.3 0.0 1.6 1 0 0 1 1 1 1 Aconitase C-terminal domain DUF521 PF04412.13 CCF43245.1 - 0.018 13.8 0.0 0.053 12.2 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF521) HXXEE PF13787.6 CCF43246.1 - 0.064 14.1 2.7 0.31 11.9 2.7 2.0 1 1 0 1 1 1 0 Protein of unknown function with HXXEE motif DUF3054 PF11255.8 CCF43246.1 - 0.23 12.0 4.9 0.18 12.3 2.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3054) Sugar_tr PF00083.24 CCF43247.1 - 7.4e-47 160.2 13.0 9.1e-47 159.9 13.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF43247.1 - 1.6e-06 27.3 16.4 1.9e-06 27.1 16.4 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Hydrolase_4 PF12146.8 CCF43250.1 - 1.4e-16 60.5 0.0 1.2e-11 44.3 0.0 2.3 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CCF43250.1 - 7.1e-11 42.2 0.2 8.9e-08 32.1 0.1 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCF43250.1 - 8.4e-06 26.5 0.0 1.3e-05 26.0 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family FSH1 PF03959.13 CCF43250.1 - 0.0003 20.5 0.0 0.0018 18.0 0.0 2.0 2 0 0 2 2 2 1 Serine hydrolase (FSH1) AXE1 PF05448.12 CCF43250.1 - 0.00062 18.5 0.0 0.085 11.5 0.0 2.6 2 1 1 3 3 3 1 Acetyl xylan esterase (AXE1) DUF818 PF05677.12 CCF43250.1 - 0.0008 18.5 0.0 0.0012 17.9 0.0 1.1 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) DLH PF01738.18 CCF43250.1 - 0.0054 16.3 0.0 0.087 12.4 0.0 2.2 1 1 0 1 1 1 1 Dienelactone hydrolase family Peptidase_S9 PF00326.21 CCF43250.1 - 0.01 15.4 0.0 0.074 12.5 0.0 2.0 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_2 PF02230.16 CCF43250.1 - 0.032 14.0 0.0 2.2 8.1 0.0 2.3 1 1 0 1 1 1 0 Phospholipase/Carboxylesterase BAAT_C PF08840.11 CCF43250.1 - 0.036 14.0 0.0 0.69 9.8 0.0 2.3 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Peptidase_S15 PF02129.18 CCF43250.1 - 0.22 11.1 0.0 20 4.6 0.0 2.1 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) p450 PF00067.22 CCF43251.1 - 0.00034 19.5 0.0 0.0004 19.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Nucleoside_tran PF01733.18 CCF43252.1 - 7.2e-38 130.7 3.5 7.2e-38 130.7 3.5 1.9 2 0 0 2 2 2 1 Nucleoside transporter MFS_1 PF07690.16 CCF43252.1 - 0.0016 17.4 6.7 0.0016 17.4 6.7 3.1 1 1 2 3 3 3 1 Major Facilitator Superfamily Glyco_transf_90 PF05686.12 CCF43253.1 - 1.4e-13 50.5 3.1 2e-11 43.4 1.6 2.9 2 1 0 2 2 2 2 Glycosyl transferase family 90 Paf1 PF03985.13 CCF43254.1 - 5.3e-83 279.4 0.0 5.7e-83 279.3 0.0 1.0 1 0 0 1 1 1 1 Paf1 Cadherin_C PF01049.17 CCF43254.1 - 0.17 12.2 2.5 5.5 7.3 0.2 2.7 1 1 1 2 2 2 0 Cadherin cytoplasmic region ABC_tran PF00005.27 CCF43255.1 - 7.5e-36 123.7 0.0 2.8e-35 121.8 0.0 2.0 2 0 0 2 2 2 1 ABC transporter ABC_membrane PF00664.23 CCF43255.1 - 3.5e-32 112.1 9.7 4.6e-32 111.8 9.7 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 CCF43255.1 - 3.5e-07 29.9 0.7 0.00012 21.6 0.0 2.4 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 CCF43255.1 - 0.00037 20.8 0.4 0.0017 18.6 0.4 2.0 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CCF43255.1 - 0.0013 18.4 0.1 0.0035 17.1 0.1 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_24 PF13479.6 CCF43255.1 - 0.002 17.9 0.0 0.0033 17.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_10 PF12846.7 CCF43255.1 - 0.0023 16.9 0.1 0.0056 15.7 0.1 1.7 1 1 0 1 1 1 1 AAA-like domain AAA_15 PF13175.6 CCF43255.1 - 0.012 15.3 0.0 0.02 14.6 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA_16 PF13191.6 CCF43255.1 - 0.015 15.6 0.9 0.18 12.2 0.9 2.2 1 1 0 1 1 1 0 AAA ATPase domain SbcCD_C PF13558.6 CCF43255.1 - 0.016 15.5 0.7 0.25 11.6 0.7 2.5 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_21 PF13304.6 CCF43255.1 - 0.044 13.6 0.0 0.24 11.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system DUF87 PF01935.17 CCF43255.1 - 0.053 13.6 0.4 0.23 11.5 0.1 2.0 2 0 0 2 2 2 0 Helicase HerA, central domain RsgA_GTPase PF03193.16 CCF43255.1 - 0.071 13.0 0.8 0.13 12.1 0.0 1.9 2 0 0 2 2 2 0 RsgA GTPase ATP-synt_ab PF00006.25 CCF43255.1 - 0.12 12.0 0.2 1 8.9 0.0 2.2 2 1 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain Pex24p PF06398.11 CCF43258.1 - 2.6e-44 151.7 8.6 3.4e-44 151.3 8.6 1.1 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin DUF202 PF02656.15 CCF43259.1 - 0.0015 18.9 3.1 0.0025 18.2 0.1 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF202) Saf_2TM PF18303.1 CCF43259.1 - 0.3 10.7 1.1 0.93 9.1 0.0 2.2 1 1 1 2 2 2 0 SAVED-fused 2TM effector domain Connexin PF00029.19 CCF43259.1 - 0.65 9.7 2.9 1.1 9.0 0.8 2.0 2 0 0 2 2 2 0 Connexin ABC_trans_N PF14510.6 CCF43260.1 - 1.7e-18 67.0 0.4 4.9e-18 65.5 0.0 1.9 2 0 0 2 2 2 1 ABC-transporter N-terminal ABC_tran PF00005.27 CCF43260.1 - 6.1e-09 36.5 0.0 1.6e-08 35.1 0.0 1.7 2 0 0 2 2 2 1 ABC transporter AAA_33 PF13671.6 CCF43260.1 - 0.017 15.3 0.1 0.043 14.0 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 CCF43260.1 - 0.023 15.1 0.1 0.12 12.8 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain P16-Arc PF04699.14 CCF43262.1 - 1.8e-50 171.3 0.0 2.1e-50 171.1 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) Methyltransf_23 PF13489.6 CCF43263.1 - 4e-10 39.8 0.0 6.2e-10 39.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF43263.1 - 3.6e-08 34.0 0.0 7.9e-08 32.8 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF43263.1 - 7.6e-06 26.5 0.0 3.2e-05 24.6 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF43263.1 - 9.5e-06 26.3 0.0 1.8e-05 25.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF43263.1 - 0.0014 18.5 0.0 0.017 14.9 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain KH_1 PF00013.29 CCF43264.1 - 5.8e-39 131.8 9.9 7.2e-16 57.8 0.1 3.2 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 CCF43264.1 - 3.8e-09 36.2 8.9 0.01 15.6 0.4 3.3 3 0 0 3 3 3 3 KH domain KH_4 PF13083.6 CCF43264.1 - 1.3e-08 34.6 2.7 0.027 14.3 0.2 3.3 3 0 0 3 3 3 3 KH domain KH_5 PF13184.6 CCF43264.1 - 0.00011 22.2 5.5 0.26 11.4 0.1 3.3 3 0 0 3 3 3 2 NusA-like KH domain UAA PF08449.11 CCF43265.1 - 5.9e-45 153.8 12.1 7.6e-45 153.4 12.1 1.1 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 CCF43265.1 - 5e-05 23.5 33.3 0.013 15.6 13.6 3.6 3 1 0 3 3 3 3 EamA-like transporter family DSPc PF00782.20 CCF43266.1 - 6.7e-24 84.2 0.1 1.6e-22 79.7 0.1 2.2 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 CCF43266.1 - 0.012 15.1 0.0 0.021 14.4 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.12 CCF43266.1 - 0.15 12.3 0.0 0.29 11.4 0.0 1.4 1 0 0 1 1 1 0 Rit1 DUSP-like domain LysM PF01476.20 CCF43267.1 - 4.4e-20 71.5 0.1 8e-10 38.6 0.0 2.2 2 0 0 2 2 2 2 LysM domain DUF3446 PF11928.8 CCF43267.1 - 1.2 9.5 8.5 2.3 8.6 8.6 1.7 1 1 0 1 1 1 0 Early growth response N-terminal domain PhyH PF05721.13 CCF43268.1 - 6.4e-10 39.6 0.0 9.6e-10 39.1 0.0 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) SCP2 PF02036.17 CCF43268.1 - 0.00047 20.6 0.0 0.00089 19.7 0.0 1.4 1 0 0 1 1 1 1 SCP-2 sterol transfer family zf-MYND PF01753.18 CCF43269.1 - 0.14 12.2 5.2 0.26 11.4 5.2 1.4 1 0 0 1 1 1 0 MYND finger Mpv17_PMP22 PF04117.12 CCF43270.1 - 9.5e-16 57.8 2.0 2e-15 56.8 2.0 1.5 1 0 0 1 1 1 1 Mpv17 / PMP22 family HMGL-like PF00682.19 CCF43271.1 - 1.3e-39 136.4 0.0 3e-37 128.6 0.0 2.3 1 1 1 2 2 2 2 HMGL-like TRAPP PF04051.16 CCF43272.1 - 3.6e-36 124.1 0.0 4.2e-36 123.9 0.0 1.0 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component DUF4250 PF14056.6 CCF43272.1 - 0.019 14.9 0.1 0.04 13.9 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4250) PNGaseA PF12222.8 CCF43272.1 - 0.028 13.3 0.0 0.031 13.2 0.0 1.1 1 0 0 1 1 1 0 Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A PS-DH PF14765.6 CCF43273.1 - 4.5e-42 144.3 0.1 6.4e-42 143.8 0.1 1.2 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 CCF43273.1 - 2.6e-17 63.3 0.0 3.6e-17 62.9 0.0 1.1 1 0 0 1 1 1 1 Acyl transferase domain Cript PF10235.9 CCF43275.1 - 8.7e-21 74.3 8.7 1.4e-20 73.6 8.7 1.3 1 0 0 1 1 1 1 Microtubule-associated protein CRIPT DUF2039 PF10217.9 CCF43275.1 - 0.015 15.7 8.5 0.015 15.7 8.5 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2039) DZR PF12773.7 CCF43275.1 - 0.22 11.6 17.2 0.11 12.5 10.0 2.8 1 1 1 2 2 2 0 Double zinc ribbon zf-ribbon_3 PF13248.6 CCF43275.1 - 0.59 9.6 13.7 0.72 9.3 2.9 3.2 2 1 1 3 3 3 0 zinc-ribbon domain CEBP_ZZ PF16366.5 CCF43275.1 - 1.4 9.2 8.1 0.31 11.3 4.2 1.8 2 0 0 2 2 2 0 Cytoplasmic polyadenylation element-binding protein ZZ domain zinc_ribbon_15 PF17032.5 CCF43275.1 - 1.8 9.4 12.6 1.4 9.7 8.0 2.7 2 1 0 2 2 2 0 zinc-ribbon family zinc_ribbon_2 PF13240.6 CCF43275.1 - 2 8.2 14.1 2.3 8.1 1.9 3.2 3 0 0 3 3 3 0 zinc-ribbon domain zf-C3HC4_3 PF13920.6 CCF43275.1 - 5.3 7.0 12.3 9 6.2 8.1 2.7 2 1 1 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Abhydrolase_1 PF00561.20 CCF43276.1 - 8.9e-27 94.4 0.1 1.8e-21 77.0 0.1 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCF43276.1 - 1.1e-18 68.6 0.2 1.5e-18 68.2 0.2 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCF43276.1 - 2.7e-12 46.5 0.0 5.7e-12 45.4 0.0 1.5 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_2 PF02230.16 CCF43276.1 - 0.055 13.3 0.0 0.58 9.9 0.0 2.3 2 1 0 2 2 2 0 Phospholipase/Carboxylesterase Pinin_SDK_memA PF04696.13 CCF43277.1 - 2.3e-35 121.5 15.0 5.2e-35 120.3 15.0 1.6 1 0 0 1 1 1 1 pinin/SDK/memA/ protein conserved region DUF3565 PF12088.8 CCF43277.1 - 0.088 12.8 0.0 0.3 11.1 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3565) PHF5 PF03660.14 CCF43278.1 - 4e-52 174.8 10.4 4.6e-52 174.6 10.4 1.0 1 0 0 1 1 1 1 PHF5-like protein PolC_DP2 PF03833.13 CCF43278.1 - 0.64 7.8 7.7 0.64 7.8 7.7 1.2 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 DZR PF12773.7 CCF43278.1 - 2.5 8.2 15.6 5.6 7.1 1.9 3.0 1 1 1 2 2 2 0 Double zinc ribbon Pex26 PF07163.12 CCF43279.1 - 0.00042 19.7 4.1 0.0005 19.5 2.8 1.7 2 0 0 2 2 2 1 Pex26 protein CDC45 PF02724.14 CCF43279.1 - 0.58 8.4 7.8 0.85 7.8 7.8 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF5401 PF17380.2 CCF43279.1 - 5.7 4.9 22.1 9.1 4.2 22.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5401) DUF3381 PF11861.8 CCF43279.1 - 6.1 6.6 17.3 9.8 5.9 17.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) CAF1 PF04857.20 CCF43280.1 - 1.8e-93 313.2 0.0 3e-93 312.5 0.0 1.3 1 1 0 1 1 1 1 CAF1 family ribonuclease His_Phos_1 PF00300.22 CCF43280.1 - 0.11 12.2 0.0 0.22 11.2 0.0 1.4 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 1) DNA_pol_phi PF04931.13 CCF43280.1 - 0.59 8.2 1.4 0.86 7.6 1.4 1.2 1 0 0 1 1 1 0 DNA polymerase phi Abhydrolase_6 PF12697.7 CCF43284.1 - 6.3e-10 40.0 0.6 1.1e-09 39.3 0.2 1.6 1 1 1 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCF43284.1 - 2.8e-09 36.6 0.0 3.8e-09 36.2 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CCF43284.1 - 1.1e-08 35.1 1.3 1.7e-08 34.5 1.1 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S15 PF02129.18 CCF43284.1 - 0.0013 18.4 0.9 0.0016 18.1 0.1 1.5 2 0 0 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_3 PF07859.13 CCF43284.1 - 0.0027 17.6 0.1 0.0049 16.8 0.1 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 CCF43284.1 - 0.056 13.2 0.3 0.43 10.3 0.2 2.0 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 CCF43284.1 - 0.11 11.9 0.0 0.26 10.7 0.0 1.6 1 1 0 1 1 1 0 Prolyl oligopeptidase family Lipase PF00151.19 CCF43284.1 - 0.12 11.7 0.1 0.18 11.1 0.1 1.2 1 0 0 1 1 1 0 Lipase AXE1 PF05448.12 CCF43284.1 - 0.47 9.1 1.2 0.59 8.8 0.5 1.4 2 0 0 2 2 2 0 Acetyl xylan esterase (AXE1) Chitin_synth_2 PF03142.15 CCF43285.1 - 3.3e-155 517.7 4.4 4.4e-155 517.3 4.4 1.2 1 0 0 1 1 1 1 Chitin synthase DEK_C PF08766.11 CCF43285.1 - 7.6e-16 57.8 0.2 1.1e-14 54.0 0.3 2.2 2 0 0 2 2 2 1 DEK C terminal domain Glyco_trans_2_3 PF13632.6 CCF43285.1 - 1.7e-15 57.4 2.3 2.9e-15 56.7 2.3 1.4 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 CCF43285.1 - 2.3e-10 40.8 0.0 4.1e-10 39.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 CCF43285.1 - 2e-05 24.2 0.0 0.00041 19.9 0.0 2.3 2 0 0 2 2 2 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 CCF43285.1 - 0.043 13.6 0.0 0.1 12.4 0.0 1.6 1 0 0 1 1 1 0 Glycosyl transferase family 2 Abhydrolase_3 PF07859.13 CCF43288.1 - 5.8e-11 42.6 0.0 1.3e-10 41.5 0.0 1.6 2 0 0 2 2 2 1 alpha/beta hydrolase fold SGL PF08450.12 CCF43289.1 - 4.7e-25 88.6 0.0 1e-24 87.5 0.0 1.5 1 1 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 CCF43289.1 - 0.00019 21.5 0.0 0.00044 20.4 0.0 1.6 1 0 0 1 1 1 1 Arylesterase NHL PF01436.21 CCF43289.1 - 0.047 13.7 0.1 0.46 10.6 0.0 2.6 2 0 0 2 2 2 0 NHL repeat Str_synth PF03088.16 CCF43289.1 - 0.073 13.2 0.0 0.21 11.8 0.0 1.7 2 0 0 2 2 2 0 Strictosidine synthase Pkinase PF00069.25 CCF43290.1 - 7.5e-17 61.6 0.0 8.9e-17 61.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF43290.1 - 1.9e-09 37.2 0.0 2.3e-09 36.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Phosphorylase PF00343.20 CCF43291.1 - 0 1057.4 0.0 0 1057.2 0.0 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase zf-C2H2_4 PF13894.6 CCF43292.1 - 0.23 12.4 6.7 5 8.2 0.2 3.1 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2 PF00096.26 CCF43292.1 - 0.56 10.8 7.4 2 9.0 0.1 2.9 3 0 0 3 3 3 0 Zinc finger, C2H2 type MRP-L46 PF11788.8 CCF43294.1 - 5.1e-27 95.0 0.0 1.2e-26 93.8 0.0 1.6 1 0 0 1 1 1 1 39S mitochondrial ribosomal protein L46 NUDIX PF00293.28 CCF43294.1 - 8.5e-05 22.6 0.1 0.00018 21.6 0.1 1.5 1 0 0 1 1 1 1 NUDIX domain AMP-binding PF00501.28 CCF43296.1 - 6.1e-06 25.1 1.1 2.3e-05 23.2 0.2 2.3 2 1 0 2 2 2 1 AMP-binding enzyme AMP-binding_C_2 PF14535.6 CCF43296.1 - 0.064 13.6 0.3 0.12 12.6 0.3 1.4 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain CLASP_N PF12348.8 CCF43297.1 - 1e-06 28.5 0.0 0.00035 20.2 0.0 2.3 2 0 0 2 2 2 2 CLASP N terminal Cnd1 PF12717.7 CCF43297.1 - 5e-05 23.4 0.1 0.026 14.6 0.1 2.4 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 CCF43297.1 - 0.00042 20.7 1.4 0.13 12.7 0.1 3.1 2 0 0 2 2 2 1 HEAT repeats HEAT PF02985.22 CCF43297.1 - 0.00064 19.8 1.3 1.6 9.2 0.1 4.1 4 0 0 4 4 4 1 HEAT repeat Adaptin_N PF01602.20 CCF43297.1 - 0.028 13.0 0.1 2.5 6.6 0.0 2.7 2 1 0 2 2 2 0 Adaptin N terminal region Jnk-SapK_ap_N PF09744.9 CCF43297.1 - 0.094 12.9 10.4 0.26 11.5 10.4 1.7 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 TAN PF11640.8 CCF43297.1 - 0.12 12.5 1.7 0.22 11.7 0.1 2.3 2 1 0 2 2 2 0 Telomere-length maintenance and DNA damage repair HALZ PF02183.18 CCF43297.1 - 0.29 11.4 9.4 1 9.6 1.1 3.0 3 0 0 3 3 2 0 Homeobox associated leucine zipper UPF0242 PF06785.11 CCF43297.1 - 0.46 10.6 3.2 1.2 9.2 3.2 1.7 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus ADIP PF11559.8 CCF43297.1 - 0.54 10.3 11.5 1.3 9.1 11.5 1.6 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding SHE3 PF17078.5 CCF43297.1 - 0.58 9.8 7.3 1.1 8.9 7.3 1.4 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 APC_N_CC PF16689.5 CCF43297.1 - 0.63 10.1 4.5 2 8.6 0.3 2.5 2 0 0 2 2 2 0 Coiled-coil N-terminus of APC, dimerisation domain CorA PF01544.18 CCF43297.1 - 0.66 9.2 7.1 1.3 8.2 7.1 1.4 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Fez1 PF06818.15 CCF43297.1 - 1 9.7 7.4 2.8 8.3 7.4 1.7 1 0 0 1 1 1 0 Fez1 KLRAQ PF10205.9 CCF43297.1 - 1.8 8.9 7.4 21 5.4 2.4 2.8 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein Spc7 PF08317.11 CCF43297.1 - 2 7.2 8.7 0.88 8.4 4.6 2.0 1 1 0 1 1 1 0 Spc7 kinetochore protein HAUS-augmin3 PF14932.6 CCF43297.1 - 2.3 7.8 7.5 13 5.3 7.3 2.1 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 3 DUF4407 PF14362.6 CCF43297.1 - 2.8 7.2 6.4 0.67 9.2 2.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) YabA PF06156.13 CCF43297.1 - 4.1 8.1 6.2 34 5.2 6.2 2.4 1 1 0 1 1 1 0 Initiation control protein YabA MRP-L46 PF11788.8 CCF43297.1 - 4.1 8.2 6.3 1.3 9.8 2.3 2.1 2 0 0 2 2 2 0 39S mitochondrial ribosomal protein L46 KH_1 PF00013.29 CCF43298.1 - 6.5e-43 144.4 6.6 3e-18 65.4 0.7 3.3 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 CCF43298.1 - 1.1e-12 47.6 3.6 0.0043 16.8 0.3 3.3 3 0 0 3 3 3 3 KH domain KH_4 PF13083.6 CCF43298.1 - 8.8e-07 28.7 0.5 0.3 11.0 0.1 3.4 3 0 0 3 3 3 2 KH domain MOEP19 PF16005.5 CCF43298.1 - 3.2e-05 23.9 0.0 0.0087 16.0 0.0 2.8 3 0 0 3 3 3 1 KH-like RNA-binding domain KH_5 PF13184.6 CCF43298.1 - 0.0014 18.6 8.7 0.32 11.1 0.3 3.4 3 0 0 3 3 3 2 NusA-like KH domain adh_short PF00106.25 CCF43299.1 - 7.9e-31 107.0 0.0 9.9e-31 106.7 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF43299.1 - 7.5e-30 104.2 0.0 1.4e-29 103.3 0.0 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Glyco_hydro_3 PF00933.21 CCF43302.1 - 3.3e-29 102.3 0.0 4.4e-29 101.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain PPR_2 PF13041.6 CCF43304.1 - 8.4e-19 67.5 0.5 5.3e-07 29.7 0.0 5.7 5 1 1 6 6 6 4 PPR repeat family PPR PF01535.20 CCF43304.1 - 5.9e-11 41.8 7.5 0.0026 17.9 0.0 6.9 8 0 0 8 8 8 3 PPR repeat PPR_3 PF13812.6 CCF43304.1 - 1.6e-08 34.5 0.4 0.019 15.0 0.0 4.2 3 2 1 4 4 4 3 Pentatricopeptide repeat domain PPR_long PF17177.4 CCF43304.1 - 3e-07 30.0 5.5 0.00063 19.2 1.8 3.2 1 1 2 3 3 3 2 Pentacotripeptide-repeat region of PRORP RPM2 PF08579.11 CCF43304.1 - 5.3e-05 23.6 0.0 0.00068 20.0 0.0 2.4 2 0 0 2 2 2 1 Mitochondrial ribonuclease P subunit (RPM2) PPR_1 PF12854.7 CCF43304.1 - 0.0062 16.2 5.6 2.7 7.8 0.0 4.8 6 0 0 6 6 6 2 PPR repeat ATP13 PF12921.7 CCF43304.1 - 0.0099 15.7 0.1 0.033 14.0 0.1 1.9 1 1 0 1 1 1 1 Mitochondrial ATPase expression TPR_14 PF13428.6 CCF43304.1 - 0.4 11.6 15.0 47 5.2 0.0 7.6 8 0 0 8 8 8 0 Tetratricopeptide repeat FSA_C PF10479.9 CCF43305.1 - 0.25 9.4 4.2 0.32 9.1 4.2 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus SOG2 PF10428.9 CCF43305.1 - 0.9 8.7 7.9 0.32 10.1 5.7 1.4 2 0 0 2 2 2 0 RAM signalling pathway protein malic PF00390.19 CCF43308.1 - 3.4e-71 238.8 0.0 5.3e-71 238.2 0.0 1.3 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain Malic_M PF03949.15 CCF43308.1 - 2.4e-60 204.0 0.0 3.6e-60 203.4 0.0 1.2 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain GMC_oxred_N PF00732.19 CCF43309.1 - 1.2e-13 51.1 0.0 2.3e-13 50.2 0.0 1.5 1 1 0 1 1 1 1 GMC oxidoreductase HHH PF00633.23 CCF43309.1 - 0.03 14.2 0.1 1.6 8.7 0.0 2.6 2 0 0 2 2 2 0 Helix-hairpin-helix motif DUF1778 PF08681.11 CCF43309.1 - 0.22 11.5 0.1 23 5.0 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1778) NAD_binding_8 PF13450.6 CCF43310.1 - 0.045 14.0 0.0 0.089 13.0 0.0 1.5 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CCF43310.1 - 0.11 11.7 0.0 0.12 11.5 0.0 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase p450 PF00067.22 CCF43312.1 - 4.8e-24 84.9 0.0 3.7e-11 42.5 0.0 2.0 2 0 0 2 2 2 2 Cytochrome P450 MFS_1 PF07690.16 CCF43313.1 - 1.7e-08 33.8 26.4 7e-07 28.5 11.5 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Zn_clus PF00172.18 CCF43314.1 - 0.12 12.5 7.7 0.29 11.3 7.7 1.6 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain TFIIA PF03153.13 CCF43314.1 - 0.15 12.0 18.2 0.22 11.5 18.2 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Ino80_Iec3 PF14612.6 CCF43314.1 - 2.9 8.5 7.3 0.31 11.7 1.5 2.1 1 1 0 2 2 2 0 IEC3 subunit of the Ino80 complex, chromatin re-modelling Sec5 PF15469.6 CCF43315.1 - 4.6e-39 134.2 0.0 1.9e-38 132.2 0.0 2.1 2 0 0 2 2 2 1 Exocyst complex component Sec5 Vps51 PF08700.11 CCF43315.1 - 0.00015 21.8 2.9 0.00029 20.8 0.1 2.8 2 0 0 2 2 2 1 Vps51/Vps67 Sec15 PF04091.12 CCF43315.1 - 0.0013 18.2 0.1 0.0025 17.3 0.1 1.4 1 0 0 1 1 1 1 Exocyst complex subunit Sec15-like Iso_dh PF00180.20 CCF43316.1 - 6.8e-100 334.6 0.0 8e-100 334.4 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Phage_30_3 PF08010.11 CCF43316.1 - 0.0066 16.2 0.0 0.013 15.3 0.0 1.4 1 0 0 1 1 1 1 Bacteriophage protein GP30.3 GTP_EFTU PF00009.27 CCF43319.1 - 9.1e-50 168.9 0.0 1.4e-49 168.3 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain LepA_C PF06421.12 CCF43319.1 - 3.8e-42 142.8 3.9 6.5e-42 142.0 3.9 1.4 1 0 0 1 1 1 1 GTP-binding protein LepA C-terminus EFG_C PF00679.24 CCF43319.1 - 2.9e-18 65.7 0.0 5.2e-18 64.9 0.0 1.4 1 0 0 1 1 1 1 Elongation factor G C-terminus Ras PF00071.22 CCF43319.1 - 5.7e-05 22.8 0.0 0.00017 21.3 0.0 1.8 2 0 0 2 2 2 1 Ras family EFG_II PF14492.6 CCF43319.1 - 6.6e-05 22.9 0.0 0.00018 21.6 0.0 1.8 1 1 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 CCF43319.1 - 0.00028 21.2 0.0 0.00067 20.0 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 CCF43319.1 - 0.0013 18.6 0.0 0.0042 16.9 0.0 1.8 2 0 0 2 2 2 1 Class II release factor RF3, C-terminal domain Roc PF08477.13 CCF43319.1 - 0.027 14.7 0.0 1.1 9.5 0.0 3.1 3 1 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 CCF43319.1 - 0.06 12.8 0.0 0.18 11.3 0.0 1.7 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit His_Phos_1 PF00300.22 CCF43320.1 - 4.9e-06 26.4 0.0 6.1e-06 26.1 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) CTNNBL PF08216.11 CCF43321.1 - 1e-40 138.1 0.0 4.2e-40 136.1 0.0 2.1 1 0 0 1 1 1 1 Catenin-beta-like, Arm-motif containing nuclear Arm PF00514.23 CCF43321.1 - 0.0023 17.9 0.2 0.53 10.4 0.0 4.0 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat Clathrin PF00637.20 CCF43321.1 - 0.01 15.7 0.2 0.88 9.4 0.0 2.9 1 1 2 3 3 3 0 Region in Clathrin and VPS HTH_15 PF12324.8 CCF43321.1 - 0.036 14.0 0.0 4.1 7.4 0.0 2.8 2 0 0 2 2 2 0 Helix-turn-helix domain of alkylmercury lyase Arm_3 PF16186.5 CCF43321.1 - 0.046 13.3 0.2 0.31 10.6 0.1 2.4 2 0 0 2 2 2 0 Atypical Arm repeat V-ATPase_G PF03179.15 CCF43322.1 - 9.1e-33 112.9 16.7 1e-32 112.8 16.7 1.0 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit DUF3552 PF12072.8 CCF43322.1 - 0.0097 15.3 10.8 0.0097 15.3 10.8 2.0 1 1 1 2 2 2 1 Domain of unknown function (DUF3552) ATP-synt_B PF00430.18 CCF43322.1 - 0.024 14.7 8.6 0.024 14.7 8.6 2.0 1 1 1 2 2 2 0 ATP synthase B/B' CF(0) V-ATPase_G_2 PF16999.5 CCF43322.1 - 0.053 13.9 14.8 0.074 13.5 14.8 1.2 1 0 0 1 1 1 0 Vacuolar (H+)-ATPase G subunit RRF PF01765.19 CCF43322.1 - 0.074 13.0 12.4 0.092 12.7 12.4 1.2 1 0 0 1 1 1 0 Ribosome recycling factor YusW PF14039.6 CCF43322.1 - 0.15 12.6 6.1 0.2 12.2 5.9 1.4 1 1 0 1 1 1 0 YusW-like protein SAPS PF04499.15 CCF43322.1 - 0.2 10.4 6.3 0.24 10.1 6.3 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF2203 PF09969.9 CCF43322.1 - 0.26 12.0 5.7 0.35 11.6 5.7 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) ATP11 PF06644.11 CCF43322.1 - 0.56 10.0 9.5 0.67 9.7 9.5 1.0 1 0 0 1 1 1 0 ATP11 protein DUF883 PF05957.13 CCF43322.1 - 5.5 7.7 9.7 34 5.1 7.4 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) PET117 PF15786.5 CCF43323.1 - 4.1e-11 43.0 15.7 3.9e-09 36.6 15.7 2.0 1 1 0 1 1 1 1 PET assembly of cytochrome c oxidase, mitochondrial RPA_interact_M PF14767.6 CCF43323.1 - 0.0064 17.0 1.4 0.15 12.7 0.5 2.0 1 1 1 2 2 2 2 Replication protein A interacting middle RNA_pol_Rpb2_6 PF00562.28 CCF43324.1 - 1.2e-125 419.7 0.1 1.8e-125 419.1 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 CCF43324.1 - 4.5e-56 189.6 0.0 1.4e-55 187.9 0.0 1.8 1 1 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 CCF43324.1 - 2.2e-47 161.2 0.0 4.3e-47 160.2 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 CCF43324.1 - 1.2e-33 115.4 0.1 2.7e-33 114.2 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_3 PF04565.16 CCF43324.1 - 2e-25 88.8 0.1 4.9e-25 87.5 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 CCF43324.1 - 4.6e-24 84.7 1.1 1.4e-23 83.2 1.1 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 RNA_pol_Rpb2_4 PF04566.13 CCF43324.1 - 2.7e-20 72.4 3.1 3.1e-20 72.2 1.4 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_45 PF10385.9 CCF43324.1 - 0.2 11.9 0.3 8.3 6.8 0.1 2.9 2 0 0 2 2 2 0 RNA polymerase beta subunit external 1 domain Glyco_hydro_45 PF02015.16 CCF43325.1 - 5.9e-42 144.0 1.6 8.5e-42 143.5 1.6 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 45 IDO PF01231.18 CCF43326.1 - 3e-167 556.8 0.0 3.4e-167 556.6 0.0 1.0 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase ASF1_hist_chap PF04729.13 CCF43327.1 - 8.6e-73 243.4 0.0 1.1e-72 243.0 0.0 1.2 1 0 0 1 1 1 1 ASF1 like histone chaperone DMSP_lyase PF16867.5 CCF43327.1 - 0.16 11.6 0.0 0.27 10.9 0.0 1.3 1 0 0 1 1 1 0 Dimethlysulfonioproprionate lyase KR PF08659.10 CCF43328.1 - 8.2e-61 205.0 0.1 1.5e-60 204.2 0.1 1.4 1 0 0 1 1 1 1 KR domain ADH_zinc_N PF00107.26 CCF43328.1 - 9.7e-17 61.2 0.0 2.6e-16 59.8 0.0 1.8 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCF43328.1 - 7.2e-16 59.5 0.0 1.9e-15 58.1 0.0 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase adh_short PF00106.25 CCF43328.1 - 3.5e-13 49.5 0.1 1.3e-11 44.4 0.0 2.2 2 0 0 2 2 2 1 short chain dehydrogenase PP-binding PF00550.25 CCF43328.1 - 1.4e-06 28.6 0.0 4.3e-06 27.0 0.0 2.0 1 0 0 1 1 1 1 Phosphopantetheine attachment site ADH_N PF08240.12 CCF43328.1 - 0.019 14.8 0.1 0.044 13.7 0.1 1.5 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain ThiF PF00899.21 CCF43328.1 - 0.098 12.0 0.0 0.21 10.9 0.0 1.4 1 0 0 1 1 1 0 ThiF family PEX11 PF05648.14 CCF43331.1 - 2.4e-73 246.3 0.8 2.7e-73 246.1 0.8 1.0 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) FBPase PF00316.20 CCF43332.1 - 2.6e-70 235.8 0.1 3.4e-70 235.4 0.1 1.2 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain DUF1295 PF06966.12 CCF43333.1 - 3.5e-40 138.0 0.8 1.8e-38 132.4 0.8 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF1295) Steroid_dh PF02544.16 CCF43333.1 - 0.0013 18.8 0.0 0.0029 17.6 0.0 1.6 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase UCR_UQCRX_QCR9 PF05365.12 CCF43333.1 - 0.087 12.8 1.0 25 4.9 0.0 3.5 3 0 0 3 3 3 0 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like GST_N PF02798.20 CCF43333.1 - 0.1 13.0 0.1 0.35 11.2 0.0 1.9 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain ERG4_ERG24 PF01222.17 CCF43333.1 - 0.13 11.0 0.0 0.2 10.4 0.0 1.3 1 0 0 1 1 1 0 Ergosterol biosynthesis ERG4/ERG24 family Homoserine_dh PF00742.19 CCF43334.1 - 1.2e-51 175.0 0.0 1.6e-51 174.7 0.0 1.1 1 0 0 1 1 1 1 Homoserine dehydrogenase NAD_binding_3 PF03447.16 CCF43334.1 - 2.9e-18 66.6 0.0 4.6e-18 66.0 0.0 1.3 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain AAA_25 PF13481.6 CCF43334.1 - 0.056 13.0 0.2 0.79 9.3 0.1 2.2 1 1 1 2 2 2 0 AAA domain CIA30 PF08547.12 CCF43335.1 - 3e-39 134.6 0.0 3.8e-39 134.3 0.0 1.1 1 0 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) p450 PF00067.22 CCF43337.1 - 6.2e-17 61.5 0.0 3e-09 36.1 0.0 2.0 1 1 1 2 2 2 2 Cytochrome P450 Sugar_tr PF00083.24 CCF43341.1 - 1.4e-06 27.5 4.7 3.4e-06 26.2 4.4 1.6 1 1 1 2 2 2 1 Sugar (and other) transporter EST1_DNA_bind PF10373.9 CCF43343.1 - 2.2e-36 125.8 0.2 2.6e-36 125.6 0.2 1.0 1 0 0 1 1 1 1 Est1 DNA/RNA binding domain EST1 PF10374.9 CCF43343.1 - 7.2e-06 26.7 0.9 2e-05 25.2 0.1 2.1 2 1 0 2 2 2 1 Telomerase activating protein Est1 p450 PF00067.22 CCF43344.1 - 8.9e-47 159.9 0.0 1.2e-46 159.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 CATSPERG PF15064.6 CCF43346.1 - 0.031 12.1 0.0 0.035 11.9 0.0 1.0 1 0 0 1 1 1 0 Cation channel sperm-associated protein subunit gamma FA_desaturase PF00487.24 CCF43346.1 - 0.039 13.8 5.6 0.056 13.3 5.3 1.3 1 1 0 1 1 1 0 Fatty acid desaturase Atg29_N PF18388.1 CCF43347.1 - 1.3e-19 69.7 0.1 2.4e-19 68.9 0.1 1.4 1 0 0 1 1 1 1 Atg29 N-terminal domain S-antigen PF05756.11 CCF43348.1 - 0.12 12.8 0.1 0.2 12.0 0.1 1.4 1 0 0 1 1 1 0 S-antigen protein PspB PF06667.12 CCF43348.1 - 0.21 11.7 0.0 0.35 11.0 0.0 1.3 1 0 0 1 1 1 0 Phage shock protein B Dfp1_Him1_M PF08630.10 CCF43349.1 - 3.2e-37 127.6 1.0 7.7e-37 126.3 0.0 2.2 2 0 0 2 2 2 1 Dfp1/Him1, central region zf-DBF PF07535.12 CCF43349.1 - 8.2e-21 73.9 0.3 1.4e-20 73.1 0.3 1.4 1 0 0 1 1 1 1 DBF zinc finger CopD PF05425.13 CCF43350.1 - 0.04 14.3 0.1 0.06 13.8 0.1 1.3 1 0 0 1 1 1 0 Copper resistance protein D RCR PF12273.8 CCF43350.1 - 1.8 9.3 14.2 13 6.5 14.2 2.4 1 1 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red Pyridoxal_deC PF00282.19 CCF43351.1 - 3e-30 105.2 0.0 3.8e-30 104.9 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_1_2 PF00155.21 CCF43351.1 - 0.0012 18.1 0.0 0.002 17.4 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 CCF43351.1 - 0.0019 17.6 0.0 0.0021 17.4 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 CCF43351.1 - 0.014 14.3 0.0 0.025 13.5 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class-V ArfGap PF01412.18 CCF43352.1 - 1.1e-39 135.1 0.4 2.3e-39 134.1 0.4 1.5 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Glyco_hydro_76 PF03663.14 CCF43353.1 - 8.7e-153 509.2 16.1 1.1e-152 508.9 16.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Abp2 PF09441.10 CCF43355.1 - 2.4e-87 291.4 0.0 3.7e-87 290.7 0.0 1.3 1 0 0 1 1 1 1 ARS binding protein 2 DUF3306 PF11748.8 CCF43355.1 - 0.024 15.5 0.2 0.024 15.5 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3306) Fungal_trans PF04082.18 CCF43356.1 - 1.7e-13 50.3 0.1 3.2e-13 49.3 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF5631 PF18645.1 CCF43356.1 - 0.093 13.1 0.0 0.23 11.9 0.0 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5631) UQ_con PF00179.26 CCF43357.1 - 5.3e-45 152.5 0.0 6.1e-45 152.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 CCF43357.1 - 0.0012 18.6 0.0 0.0015 18.2 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 CCF43357.1 - 0.024 14.5 0.0 0.035 14.0 0.0 1.3 1 0 0 1 1 1 0 UEV domain RWD PF05773.22 CCF43357.1 - 0.056 13.7 0.0 0.14 12.4 0.0 1.9 1 1 1 2 2 2 0 RWD domain RabGAP-TBC PF00566.18 CCF43358.1 - 4.1e-34 118.1 0.0 9e-20 71.2 0.0 2.1 2 0 0 2 2 2 2 Rab-GTPase-TBC domain Copper-fist PF00649.18 CCF43359.1 - 2.5e-22 78.1 2.9 2.5e-22 78.1 2.9 4.3 1 1 3 4 4 4 1 Copper fist DNA binding domain LEA_6 PF10714.9 CCF43359.1 - 0.092 12.8 0.6 15 5.8 0.2 2.6 2 0 0 2 2 2 0 Late embryogenesis abundant protein 18 Leu_leader PF08054.11 CCF43359.1 - 0.2 11.3 0.2 7.1 6.3 0.1 2.3 2 0 0 2 2 2 0 Leucine operon leader peptide ECH_1 PF00378.20 CCF43360.1 - 9.4e-30 103.7 0.0 1.1e-29 103.5 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CCF43360.1 - 0.011 15.3 0.0 0.14 11.6 0.0 1.9 1 1 1 2 2 2 0 Enoyl-CoA hydratase/isomerase Sugar_tr PF00083.24 CCF43361.1 - 1.4e-108 363.7 20.9 1.5e-108 363.5 20.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF43361.1 - 3.3e-28 98.6 60.5 1.9e-23 83.0 28.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 CCF43361.1 - 0.00037 18.9 0.9 0.00098 17.5 0.9 1.7 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family DUF3917 PF13055.6 CCF43361.1 - 0.7 10.4 5.5 0.23 11.9 0.6 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3917) EF-hand_1 PF00036.32 CCF43362.1 - 7.9e-38 125.2 14.2 2.4e-09 36.1 2.1 4.1 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 CCF43362.1 - 1.8e-34 118.0 3.2 6.8e-18 64.9 0.2 2.0 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 CCF43362.1 - 2.5e-30 101.8 9.5 1e-08 34.4 0.0 4.1 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 CCF43362.1 - 1e-27 95.7 9.2 4.4e-13 48.8 0.2 3.7 2 2 2 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 CCF43362.1 - 4.6e-23 79.6 14.5 3.8e-07 29.3 0.0 4.2 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 CCF43362.1 - 3.4e-17 62.5 0.2 3.5e-08 33.6 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 CCF43362.1 - 3.9e-09 36.4 1.4 0.0021 18.0 0.2 2.2 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 CCF43362.1 - 4e-06 27.1 0.1 0.043 14.1 0.0 2.1 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_14 PF17959.1 CCF43362.1 - 8e-06 26.1 0.1 0.0011 19.3 0.0 2.4 2 1 0 2 2 2 1 EF-hand domain TerB PF05099.13 CCF43362.1 - 0.00051 20.0 0.2 0.76 9.7 0.0 2.4 1 1 1 2 2 2 2 Tellurite resistance protein TerB Caleosin PF05042.13 CCF43362.1 - 0.0031 17.4 1.0 12 5.8 0.0 3.5 1 1 2 3 3 3 0 Caleosin related protein EFhand_Ca_insen PF08726.10 CCF43362.1 - 0.0051 16.9 0.1 0.037 14.1 0.0 2.2 2 0 0 2 2 2 1 Ca2+ insensitive EF hand EF-hand_11 PF08976.11 CCF43362.1 - 0.015 16.1 0.0 0.82 10.6 0.0 2.1 1 1 1 2 2 2 0 EF-hand domain Toprim_4 PF13662.6 CCF43362.1 - 0.018 15.5 1.3 5 7.7 0.0 2.9 2 1 1 3 3 3 0 Toprim domain UPF0154 PF03672.13 CCF43362.1 - 0.034 14.2 0.0 1.7 8.8 0.0 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0154) MecA_N PF05223.11 CCF43362.1 - 0.048 13.9 0.2 0.17 12.2 0.1 1.8 1 1 1 2 2 2 0 NTF2-like N-terminal transpeptidase domain SurA_N_3 PF13624.6 CCF43362.1 - 0.052 13.3 0.1 1 9.2 0.0 2.1 1 1 1 2 2 2 0 SurA N-terminal domain SurA_N_2 PF13623.6 CCF43362.1 - 0.064 13.1 0.2 1.8 8.4 0.0 2.3 1 1 1 2 2 2 0 SurA N-terminal domain Toprim PF01751.22 CCF43362.1 - 0.13 12.5 0.7 1.3 9.2 0.0 2.3 1 1 1 2 2 2 0 Toprim domain BRE1 PF08647.11 CCF43365.1 - 3e-23 81.7 10.7 3e-23 81.7 10.7 6.7 4 2 3 7 7 7 2 BRE1 E3 ubiquitin ligase zf-C3HC4_3 PF13920.6 CCF43365.1 - 1.5e-08 34.4 7.5 2.3e-08 33.7 7.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CCF43365.1 - 7.9e-08 32.0 7.3 1.3e-07 31.3 7.3 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 CCF43365.1 - 1.4e-07 31.2 10.7 2.5e-07 30.5 10.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CCF43365.1 - 1.1e-06 28.5 6.4 2.1e-06 27.7 6.4 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 CCF43365.1 - 1.8e-06 27.7 10.0 3.2e-06 26.9 10.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CCF43365.1 - 7.8e-06 26.1 9.2 1.3e-05 25.4 9.2 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 CCF43365.1 - 1.1e-05 25.2 10.4 1.9e-05 24.5 10.4 1.4 1 0 0 1 1 1 1 zinc-RING finger domain JIP_LZII PF16471.5 CCF43365.1 - 0.00028 21.0 2.4 0.00028 21.0 2.4 7.1 7 1 1 8 8 8 2 JNK-interacting protein leucine zipper II DivIC PF04977.15 CCF43365.1 - 0.00081 19.1 2.3 0.00081 19.1 2.3 10.0 6 3 4 10 10 10 2 Septum formation initiator TPR_MLP1_2 PF07926.12 CCF43365.1 - 0.0033 17.5 13.7 0.0033 17.5 13.7 6.8 3 2 3 6 6 6 1 TPR/MLP1/MLP2-like protein DUF1664 PF07889.12 CCF43365.1 - 0.0064 16.5 1.4 0.0064 16.5 1.4 6.4 5 2 2 7 7 7 1 Protein of unknown function (DUF1664) ATG16 PF08614.11 CCF43365.1 - 0.0092 16.2 17.1 0.0092 16.2 17.1 5.7 3 2 1 5 5 5 1 Autophagy protein 16 (ATG16) zf-C3HC4_4 PF15227.6 CCF43365.1 - 0.011 15.9 6.6 0.021 15.0 6.6 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING bZIP_1 PF00170.21 CCF43365.1 - 0.012 15.7 1.3 0.012 15.7 1.3 8.5 10 1 1 11 11 9 0 bZIP transcription factor TerY_C PF15616.6 CCF43365.1 - 0.03 14.4 0.7 0.03 14.4 0.7 2.9 3 0 0 3 3 3 0 TerY-C metal binding domain zf-RING_4 PF14570.6 CCF43365.1 - 0.034 13.9 7.5 0.12 12.2 7.6 1.9 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zf-UDP PF14569.6 CCF43365.1 - 0.17 12.0 3.2 0.47 10.6 3.2 1.7 1 0 0 1 1 1 0 Zinc-binding RING-finger zf-RING_6 PF14835.6 CCF43365.1 - 0.5 10.3 2.6 1 9.3 2.6 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-rbx1 PF12678.7 CCF43365.1 - 0.57 10.5 8.4 2.6 8.4 8.4 2.0 1 1 0 1 1 1 0 RING-H2 zinc finger domain DUF1272 PF06906.11 CCF43365.1 - 0.9 9.7 5.5 2.1 8.5 5.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) zf-RING_10 PF16685.5 CCF43365.1 - 1.2 9.3 6.4 2.8 8.1 6.4 1.6 1 0 0 1 1 1 0 zinc RING finger of MSL2 DZR PF12773.7 CCF43365.1 - 2.5 8.2 7.1 4.9 7.3 7.1 1.4 1 0 0 1 1 1 0 Double zinc ribbon TSC22 PF01166.18 CCF43365.1 - 4.5 7.6 24.8 0.8 10.1 0.6 6.9 6 2 0 6 6 6 0 TSC-22/dip/bun family SARAF PF06682.12 CCF43366.1 - 1e-103 347.5 2.9 1.2e-103 347.3 2.9 1.0 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis Fic PF02661.18 CCF43367.1 - 7.2e-14 52.5 0.0 2.6e-13 50.7 0.0 2.0 2 1 0 2 2 2 1 Fic/DOC family ABC_membrane PF00664.23 CCF43369.1 - 3.8e-20 72.7 9.6 7.5e-16 58.6 0.5 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region Actin PF00022.19 CCF43370.1 - 2.3e-21 75.9 0.0 7.3e-12 44.6 0.0 2.4 2 1 0 2 2 2 2 Actin Actin_micro PF17003.5 CCF43370.1 - 7.3e-05 22.1 1.0 0.16 11.1 0.3 2.1 2 0 0 2 2 2 2 Putative actin-like family FtsA PF14450.6 CCF43370.1 - 0.0017 18.7 0.0 0.0042 17.5 0.0 1.8 1 1 0 1 1 1 1 Cell division protein FtsA MreB_Mbl PF06723.13 CCF43370.1 - 0.006 15.5 0.0 0.02 13.7 0.0 1.7 2 0 0 2 2 2 1 MreB/Mbl protein DUF3413 PF11893.8 CCF43371.1 - 0.34 10.0 3.9 0.26 10.4 3.1 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF3413) ERCC3_RAD25_C PF16203.5 CCF43372.1 - 3.3e-123 409.7 0.2 4.6e-123 409.3 0.2 1.2 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Helicase_C PF00271.31 CCF43372.1 - 1.7e-11 44.4 0.1 3.2e-11 43.5 0.1 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCF43372.1 - 0.0084 16.1 0.0 0.025 14.6 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ADC PF06314.11 CCF43374.1 - 0.00079 19.1 0.0 0.0014 18.3 0.0 1.3 1 0 0 1 1 1 1 Acetoacetate decarboxylase (ADC) MFS_1 PF07690.16 CCF43375.1 - 1.8e-31 109.4 6.2 2.1e-31 109.2 6.2 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF43375.1 - 1.4e-08 34.0 1.4 1.7e-08 33.8 1.4 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter CLN3 PF02487.17 CCF43375.1 - 0.00088 18.4 0.0 0.96 8.4 0.0 2.2 1 1 0 2 2 2 2 CLN3 protein Sensor PF13796.6 CCF43375.1 - 0.0028 17.7 0.0 0.0028 17.7 0.0 2.5 1 1 1 2 2 2 1 Putative sensor Kinesin PF00225.23 CCF43376.1 - 4.3e-51 173.8 0.0 7.6e-51 173.0 0.0 1.4 1 1 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 CCF43376.1 - 7.6e-05 22.7 0.0 0.00013 21.9 0.0 1.4 1 0 0 1 1 1 1 Microtubule binding AAA_16 PF13191.6 CCF43376.1 - 0.12 12.8 0.1 0.25 11.7 0.1 1.7 1 1 0 1 1 1 0 AAA ATPase domain PAPS_reduct PF01507.19 CCF43377.1 - 1.9e-06 28.1 0.1 2.5e-06 27.7 0.1 1.2 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family Mito_carr PF00153.27 CCF43379.1 - 1.1e-16 60.6 0.4 1.3e-16 60.3 0.4 1.1 1 0 0 1 1 1 1 Mitochondrial carrier protein MARVEL PF01284.23 CCF43380.1 - 0.00072 19.6 25.8 0.0028 17.7 25.8 1.8 1 1 0 1 1 1 1 Membrane-associating domain Holin_SPP1 PF04688.13 CCF43380.1 - 0.04 14.1 3.1 0.078 13.2 3.1 1.5 1 0 0 1 1 1 0 SPP1 phage holin COPI_assoc PF08507.10 CCF43380.1 - 0.046 13.8 17.8 0.46 10.5 4.3 2.1 1 1 1 2 2 2 0 COPI associated protein GILT PF03227.16 CCF43381.1 - 0.04 14.2 0.0 0.045 14.0 0.0 1.2 1 0 0 1 1 1 0 Gamma interferon inducible lysosomal thiol reductase (GILT) Astacin PF01400.24 CCF43382.1 - 2e-31 109.1 0.0 1.7e-30 106.0 0.0 2.2 1 1 0 1 1 1 1 Astacin (Peptidase family M12A) zf-C4 PF00105.18 CCF43382.1 - 0.038 14.5 1.0 6.2 7.4 0.6 2.5 2 0 0 2 2 2 0 Zinc finger, C4 type (two domains) AMP-binding PF00501.28 CCF43383.1 - 1.6e-163 544.3 0.0 6.9e-81 272.0 0.0 2.2 2 0 0 2 2 2 2 AMP-binding enzyme NAD_binding_4 PF07993.12 CCF43383.1 - 6.5e-41 140.2 0.0 1e-40 139.5 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein Condensation PF00668.20 CCF43383.1 - 3.2e-34 118.4 0.0 6e-34 117.5 0.0 1.4 1 0 0 1 1 1 1 Condensation domain PP-binding PF00550.25 CCF43383.1 - 1.4e-17 63.8 0.2 9.3e-11 41.9 0.0 2.9 2 0 0 2 2 2 2 Phosphopantetheine attachment site Epimerase PF01370.21 CCF43383.1 - 3.6e-08 33.2 0.0 8.1e-08 32.0 0.0 1.6 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family AMP-binding_C PF13193.6 CCF43383.1 - 0.0066 17.4 0.0 0.18 12.8 0.0 2.9 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain NAD_binding_10 PF13460.6 CCF43383.1 - 0.03 14.2 0.2 0.079 12.9 0.2 1.7 1 0 0 1 1 1 0 NAD(P)H-binding 3Beta_HSD PF01073.19 CCF43383.1 - 0.047 12.7 0.0 0.25 10.3 0.0 1.9 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Amidase PF01425.21 CCF43384.1 - 2.2e-76 257.7 1.1 2.7e-76 257.3 1.1 1.0 1 0 0 1 1 1 1 Amidase Glyoxal_oxid_N PF07250.11 CCF43386.1 - 3.3e-24 85.4 0.0 1e-23 83.8 0.0 1.7 2 0 0 2 2 2 1 Glyoxal oxidase N-terminus DUF1929 PF09118.11 CCF43386.1 - 8.9e-21 74.0 0.0 1.6e-20 73.2 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1929) WSC PF01822.19 CCF43386.1 - 1.2e-14 54.3 3.3 1.9e-14 53.6 3.3 1.3 1 0 0 1 1 1 1 WSC domain Kelch_6 PF13964.6 CCF43386.1 - 0.032 14.5 0.5 1.2 9.5 0.0 3.6 4 0 0 4 4 4 0 Kelch motif Macro_2 PF14519.6 CCF43386.1 - 0.086 12.2 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 Macro-like domain Kelch_2 PF07646.15 CCF43386.1 - 0.12 12.4 0.4 3.9 7.6 0.1 3.2 2 1 1 3 3 3 0 Kelch motif UBM PF14377.6 CCF43387.1 - 0.02 14.4 0.0 0.054 13.0 0.0 1.8 1 0 0 1 1 1 0 Ubiquitin binding region Methyltransf_16 PF10294.9 CCF43391.1 - 1.7e-12 47.4 0.0 6.3e-12 45.6 0.0 1.8 1 1 0 1 1 1 1 Lysine methyltransferase PrmA PF06325.13 CCF43391.1 - 0.0035 16.8 0.1 0.0047 16.4 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) GidB PF02527.15 CCF43391.1 - 0.084 12.2 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G Methyltransf_23 PF13489.6 CCF43391.1 - 0.17 11.7 0.0 0.22 11.4 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain COesterase PF00135.28 CCF43392.1 - 4.2e-11 42.4 0.0 4.8e-11 42.2 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family COesterase PF00135.28 CCF43393.1 - 3.5e-07 29.5 0.0 4e-07 29.3 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family HsbA PF12296.8 CCF43395.1 - 4.6e-21 75.5 10.4 7.7e-21 74.7 10.4 1.4 1 0 0 1 1 1 1 Hydrophobic surface binding protein A DEC-1_N PF04625.13 CCF43395.1 - 0.03 13.3 10.7 0.043 12.8 10.7 1.3 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region Cation_ATPase_N PF00690.26 CCF43397.1 - 2.3e-16 59.2 0.1 3.4e-16 58.7 0.1 1.2 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus EMC3_TMCO1 PF01956.16 CCF43397.1 - 0.0041 16.9 0.0 0.0049 16.6 0.0 1.1 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like DUF4059 PF13268.6 CCF43397.1 - 0.053 13.9 2.3 1 9.8 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4059) TPR_22 PF18833.1 CCF43399.1 - 1.3e-09 38.1 0.1 8.3e-09 35.5 0.0 2.2 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 CCF43399.1 - 9.1e-06 26.2 2.2 5.6e-05 23.7 0.0 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 CCF43399.1 - 1.3e-05 25.6 0.4 1.3e-05 25.6 0.4 2.7 2 1 2 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 CCF43399.1 - 0.00091 19.9 1.0 0.97 10.4 0.1 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 CCF43399.1 - 0.01 15.9 1.1 11 6.4 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat RPN6_N PF18055.1 CCF43399.1 - 0.01 16.2 1.8 0.037 14.4 0.1 2.6 2 1 1 3 3 3 0 26S proteasome regulatory subunit RPN6 N-terminal domain TPR_17 PF13431.6 CCF43399.1 - 0.065 13.6 0.2 22 5.7 0.0 3.3 1 1 2 3 3 3 0 Tetratricopeptide repeat DUF4919 PF16266.5 CCF43399.1 - 0.075 13.0 0.3 0.2 11.6 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4919) MFS_1 PF07690.16 CCF43400.1 - 1.2e-31 110.0 51.1 6.9e-29 100.9 49.3 3.3 2 1 1 3 3 3 2 Major Facilitator Superfamily HET PF06985.11 CCF43401.1 - 3.6e-32 111.7 0.0 7.4e-32 110.7 0.0 1.6 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) NOA36 PF06524.12 CCF43401.1 - 0.085 12.2 11.6 0.14 11.4 11.6 1.3 1 0 0 1 1 1 0 NOA36 protein SDA1 PF05285.12 CCF43401.1 - 1.5 8.2 8.1 2.3 7.5 8.1 1.2 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 CCF43401.1 - 4.4 5.4 10.1 6.1 4.9 10.1 1.1 1 0 0 1 1 1 0 Nop14-like family Astro_capsid_p PF12226.8 CCF43401.1 - 6.8 5.7 8.6 9.9 5.2 8.6 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein adh_short PF00106.25 CCF43405.1 - 8.2e-23 80.9 0.0 1.2e-22 80.3 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF43405.1 - 3.6e-16 59.5 0.0 4.5e-16 59.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 CCF43405.1 - 4.3e-11 42.8 0.0 5.4e-11 42.4 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 CCF43405.1 - 3.4e-10 40.1 0.1 4.4e-10 39.8 0.1 1.1 1 0 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 CCF43405.1 - 5e-06 26.1 0.0 1e-05 25.1 0.0 1.4 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 CCF43405.1 - 0.00028 20.8 0.0 0.00037 20.4 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Fungal_trans PF04082.18 CCF43406.1 - 2.4e-25 89.1 0.1 3.4e-25 88.6 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Phage_Coat_Gp8 PF05371.12 CCF43406.1 - 0.014 15.2 0.0 0.026 14.3 0.0 1.5 1 0 0 1 1 1 0 Phage major coat protein, Gp8 Shisa PF13908.6 CCF43409.1 - 0.013 15.7 0.9 0.023 14.9 0.1 1.6 1 1 1 2 2 2 0 Wnt and FGF inhibitory regulator ADH_zinc_N PF00107.26 CCF43410.1 - 1.6e-08 34.6 0.0 2.5e-08 34.0 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCF43410.1 - 0.00023 21.0 0.0 0.00059 19.7 0.0 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 CCF43410.1 - 0.0067 17.5 0.0 0.018 16.1 0.0 1.8 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ketoacyl-synt PF00109.26 CCF43411.1 - 1.4e-76 257.4 0.0 2.9e-76 256.4 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 CCF43411.1 - 3.6e-53 180.2 0.0 7.6e-53 179.1 0.0 1.6 1 0 0 1 1 1 1 KR domain PS-DH PF14765.6 CCF43411.1 - 3.3e-48 164.4 0.0 6.3e-48 163.5 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 CCF43411.1 - 7.4e-39 134.1 0.0 1.6e-38 133.0 0.0 1.5 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 CCF43411.1 - 2.8e-30 104.7 0.0 6.6e-30 103.6 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Methyltransf_12 PF08242.12 CCF43411.1 - 1.3e-16 61.1 0.0 3.9e-16 59.6 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain KAsynt_C_assoc PF16197.5 CCF43411.1 - 2.3e-14 53.8 0.0 7.9e-14 52.1 0.0 2.0 2 0 0 2 2 1 1 Ketoacyl-synthetase C-terminal extension Methyltransf_25 PF13649.6 CCF43411.1 - 3.4e-13 50.1 0.1 1.8e-12 47.8 0.0 2.4 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF43411.1 - 3.7e-13 49.9 0.0 1.1e-12 48.4 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain adh_short PF00106.25 CCF43411.1 - 1.9e-12 47.1 0.0 5.3e-12 45.6 0.0 1.8 1 0 0 1 1 1 1 short chain dehydrogenase Methyltransf_31 PF13847.6 CCF43411.1 - 3.7e-12 46.3 0.0 7.9e-12 45.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF43411.1 - 2.4e-10 40.5 0.0 5e-10 39.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain adh_short_C2 PF13561.6 CCF43411.1 - 1.2e-06 28.2 0.0 3.1e-06 26.9 0.0 1.7 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Thiolase_N PF00108.23 CCF43411.1 - 7e-06 25.6 0.1 4.6e-05 22.9 0.0 2.2 3 0 0 3 3 3 1 Thiolase, N-terminal domain PP-binding PF00550.25 CCF43411.1 - 0.00013 22.2 0.6 0.00031 21.0 0.6 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site Methyltransf_16 PF10294.9 CCF43411.1 - 0.0023 17.7 0.0 0.0045 16.7 0.0 1.4 1 0 0 1 1 1 1 Lysine methyltransferase Ubie_methyltran PF01209.18 CCF43411.1 - 0.0048 16.3 0.0 0.0092 15.3 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family DUF4350 PF14258.6 CCF43411.1 - 0.098 13.1 0.6 7 7.2 0.1 3.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4350) HIG_1_N PF04588.13 CCF43412.1 - 5.4e-23 81.0 0.7 9.8e-23 80.1 0.7 1.5 1 0 0 1 1 1 1 Hypoxia induced protein conserved region O-ag_pol_Wzy PF14296.6 CCF43412.1 - 0.2 10.3 0.0 0.25 10.0 0.0 1.1 1 0 0 1 1 1 0 O-antigen polysaccharide polymerase Wzy Git3 PF11710.8 CCF43413.1 - 4.1e-64 216.1 11.8 7.9e-64 215.2 11.8 1.4 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 GPR_Gpa2_C PF11970.8 CCF43413.1 - 1.4e-20 73.1 0.4 4e-20 71.7 0.4 1.8 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 C-term 7tm_1 PF00001.21 CCF43413.1 - 9.3e-09 35.0 0.1 1.3e-08 34.5 0.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) ApbA_C PF08546.11 CCF43417.1 - 6.9e-28 97.4 0.1 1e-27 96.8 0.1 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 CCF43417.1 - 1.5e-23 83.1 0.0 2.2e-23 82.6 0.0 1.2 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ThiF PF00899.21 CCF43417.1 - 0.027 13.8 0.8 0.058 12.7 0.5 1.6 2 0 0 2 2 2 0 ThiF family DNA_binding_1 PF01035.20 CCF43418.1 - 1.2e-07 31.7 0.0 1.6e-07 31.3 0.0 1.2 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain Spc7 PF08317.11 CCF43419.1 - 0.00032 19.7 20.6 0.00032 19.7 20.6 3.5 2 2 1 3 3 3 1 Spc7 kinetochore protein Fib_alpha PF08702.10 CCF43419.1 - 0.016 15.4 31.5 0.064 13.4 0.5 4.2 2 1 1 4 4 4 0 Fibrinogen alpha/beta chain family DUF1664 PF07889.12 CCF43419.1 - 0.023 14.8 3.0 0.023 14.8 3.0 4.9 2 1 1 4 4 4 0 Protein of unknown function (DUF1664) LMBR1 PF04791.16 CCF43419.1 - 0.038 12.9 0.1 0.038 12.9 0.1 2.6 1 1 1 2 2 2 0 LMBR1-like membrane protein DUF2294 PF10057.9 CCF43419.1 - 0.047 13.8 1.2 0.047 13.8 1.2 3.0 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2294) AlkA_N PF06029.11 CCF43419.1 - 0.12 12.6 2.0 0.37 11.1 0.3 2.6 2 0 0 2 2 2 0 AlkA N-terminal domain TFR_dimer PF04253.15 CCF43419.1 - 0.49 10.5 8.9 8.4 6.5 1.2 3.8 3 0 0 3 3 3 0 Transferrin receptor-like dimerisation domain DUF4407 PF14362.6 CCF43419.1 - 4 6.7 47.5 2.6 7.3 7.0 3.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4407) Lebercilin PF15619.6 CCF43419.1 - 8.6 6.0 64.0 1.8 8.2 23.3 4.4 3 1 1 4 4 4 0 Ciliary protein causing Leber congenital amaurosis disease DUF3618 PF12277.8 CCF43420.1 - 0.0029 17.8 0.4 0.0083 16.4 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3618) Glyco_hydro_47 PF01532.20 CCF43421.1 - 2.3e-127 425.7 0.0 3e-127 425.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 SARAF PF06682.12 CCF43421.1 - 0.023 14.4 0.3 0.06 13.0 0.3 1.6 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis ATG101 PF07855.12 CCF43422.1 - 2.7e-58 196.4 0.0 3.1e-58 196.1 0.0 1.0 1 0 0 1 1 1 1 Autophagy-related protein 101 Mo-co_dimer PF03404.16 CCF43422.1 - 0.03 14.3 0.1 0.051 13.6 0.1 1.4 1 0 0 1 1 1 0 Mo-co oxidoreductase dimerisation domain Ribosomal_S8e PF01201.22 CCF43424.1 - 2e-55 186.7 1.6 2.4e-55 186.5 1.6 1.1 1 0 0 1 1 1 1 Ribosomal protein S8e RabGAP-TBC PF00566.18 CCF43425.1 - 2.8e-49 167.7 1.3 2.8e-49 167.7 1.3 2.5 2 1 0 2 2 2 1 Rab-GTPase-TBC domain HALZ PF02183.18 CCF43425.1 - 0.00016 21.8 12.6 0.031 14.5 0.8 3.5 3 0 0 3 3 3 2 Homeobox associated leucine zipper Cnn_1N PF07989.11 CCF43425.1 - 0.00035 20.7 6.7 0.00035 20.7 6.7 3.1 2 1 1 3 3 3 2 Centrosomin N-terminal motif 1 Jnk-SapK_ap_N PF09744.9 CCF43425.1 - 0.0017 18.6 20.4 0.0017 18.6 20.4 3.1 2 2 1 3 3 3 1 JNK_SAPK-associated protein-1 KASH_CCD PF14662.6 CCF43425.1 - 0.0068 16.3 26.4 0.017 15.0 26.4 1.7 1 1 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH FlaC_arch PF05377.11 CCF43425.1 - 1.4 9.4 13.4 1.3 9.5 2.3 3.8 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) Scaffolding_pro PF11418.8 CCF43425.1 - 1.6 9.3 8.1 11 6.6 0.5 3.4 1 1 2 3 3 3 0 Phi29 scaffolding protein ADIP PF11559.8 CCF43425.1 - 3.6 7.6 33.1 3.1 7.9 10.1 3.3 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding DUF4094 PF13334.6 CCF43425.1 - 4.3 7.8 11.1 1.3 9.5 6.6 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4094) YabA PF06156.13 CCF43425.1 - 5.9 7.6 24.9 0.17 12.6 4.6 3.3 2 2 1 3 3 3 0 Initiation control protein YabA DUF1664 PF07889.12 CCF43425.1 - 6.8 6.7 13.4 8.1 6.5 6.1 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) bZIP_1 PF00170.21 CCF43425.1 - 9 6.5 25.9 2.4 8.3 3.7 4.2 3 1 0 3 3 3 0 bZIP transcription factor Glyco_hydro_63 PF03200.16 CCF43426.1 - 6.3e-172 572.7 0.1 9.1e-171 568.9 0.1 1.9 1 1 0 1 1 1 1 Glycosyl hydrolase family 63 C-terminal domain Trehalase PF01204.18 CCF43426.1 - 1.2e-08 34.3 0.1 1.9e-08 33.6 0.1 1.2 1 0 0 1 1 1 1 Trehalase MFS_1 PF07690.16 CCF43427.1 - 2.8e-11 43.0 17.0 2.8e-11 43.0 17.0 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily p450 PF00067.22 CCF43428.1 - 3.3e-17 62.4 0.0 3.8e-17 62.2 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 CCF43429.1 - 2e-71 241.1 0.0 2.3e-71 240.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 PALP PF00291.25 CCF43430.1 - 1.1e-16 61.1 1.1 1.3e-16 60.9 1.1 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme INSIG PF07281.12 CCF43430.1 - 0.13 11.8 0.0 0.15 11.7 0.0 1.1 1 0 0 1 1 1 0 Insulin-induced protein (INSIG) DIT1_PvcA PF05141.12 CCF43431.1 - 1.5e-96 323.1 0.0 2e-96 322.7 0.0 1.2 1 0 0 1 1 1 1 Pyoverdine/dityrosine biosynthesis protein DUF4551 PF15087.6 CCF43431.1 - 0.11 11.3 0.0 0.16 10.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) WW_1 PF18507.1 CCF43431.1 - 0.17 11.6 0.0 0.38 10.5 0.0 1.6 1 0 0 1 1 1 0 WW domain Dynamin_N PF00350.23 CCF43432.1 - 3.9e-31 108.4 0.0 9.2e-31 107.2 0.0 1.7 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 CCF43432.1 - 4.9e-16 58.8 0.0 4.5e-15 55.6 0.0 2.2 1 1 0 1 1 1 1 Dynamin central region MMR_HSR1 PF01926.23 CCF43432.1 - 1.2e-05 25.3 0.0 3.2e-05 24.0 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.27 CCF43432.1 - 0.027 15.0 0.0 0.09 13.3 0.0 1.9 1 0 0 1 1 1 0 ABC transporter AAA_15 PF13175.6 CCF43432.1 - 0.032 14.0 0.3 0.53 9.9 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain RMI1_C PF16099.5 CCF43432.1 - 0.22 11.3 0.9 1.3 8.9 0.1 2.3 2 0 0 2 2 2 0 Recq-mediated genome instability protein 1, C-terminal OB-fold DotU PF09850.9 CCF43432.1 - 0.32 10.7 2.4 7 6.3 0.1 2.9 3 0 0 3 3 3 0 Type VI secretion system protein DotU SOG2 PF10428.9 CCF43433.1 - 0.026 13.7 9.7 0.029 13.6 9.7 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein p450 PF00067.22 CCF43434.1 - 0.019 13.8 0.0 0.027 13.2 0.0 1.2 1 0 0 1 1 1 0 Cytochrome P450 ERG4_ERG24 PF01222.17 CCF43435.1 - 4.8e-54 183.7 0.1 5.5e-54 183.6 0.1 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 CCF43435.1 - 0.0012 18.5 0.9 0.0025 17.4 0.3 1.8 2 1 0 2 2 2 1 Protein of unknown function (DUF1295) Prefoldin PF02996.17 CCF43437.1 - 0.076 12.9 0.5 0.16 11.9 0.5 1.5 1 0 0 1 1 1 0 Prefoldin subunit ADIP PF11559.8 CCF43437.1 - 0.32 11.1 5.3 0.89 9.6 1.6 2.6 2 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding NCBP3 PF10309.9 CCF43438.1 - 1.8e-21 75.7 0.0 2.9e-21 75.1 0.0 1.3 1 0 0 1 1 1 1 Nuclear cap-binding protein subunit 3 Apolipoprotein PF01442.18 CCF43439.1 - 0.0016 18.4 8.1 0.0025 17.7 8.1 1.2 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain Seryl_tRNA_N PF02403.22 CCF43439.1 - 0.044 14.0 0.3 14 5.9 0.0 2.5 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain HMMR_N PF15905.5 CCF43439.1 - 0.075 12.5 4.0 0.12 11.8 4.0 1.2 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal DUF5320 PF17253.2 CCF43439.1 - 0.081 14.0 0.2 0.21 12.7 0.0 1.7 2 0 0 2 2 1 0 Family of unknown function (DUF5320) Packaging_FI PF14000.6 CCF43439.1 - 0.089 13.3 2.8 0.099 13.1 0.9 1.9 1 1 1 2 2 2 0 DNA packaging protein FI HemX PF04375.14 CCF43439.1 - 0.094 12.0 1.8 0.14 11.5 1.8 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Gp58 PF07902.11 CCF43439.1 - 0.15 10.3 3.6 0.2 9.9 3.6 1.1 1 0 0 1 1 1 0 gp58-like protein HWE_HK PF07536.14 CCF43439.1 - 0.15 12.7 2.6 9.5 7.0 0.1 2.6 1 1 0 2 2 2 0 HWE histidine kinase Spectrin PF00435.21 CCF43439.1 - 0.16 12.5 7.4 0.16 12.5 3.2 2.3 1 1 1 2 2 2 0 Spectrin repeat Exonuc_VII_L PF02601.15 CCF43439.1 - 0.19 11.3 2.0 0.29 10.6 2.0 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Baculo_PEP_C PF04513.12 CCF43439.1 - 0.19 11.7 0.1 0.48 10.5 0.1 1.7 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus BLOC1_2 PF10046.9 CCF43439.1 - 0.23 11.8 3.5 4.4 7.7 0.1 2.6 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 GrpE PF01025.19 CCF43439.1 - 0.35 10.5 1.4 0.55 9.9 1.4 1.3 1 0 0 1 1 1 0 GrpE IFT57 PF10498.9 CCF43439.1 - 0.45 9.4 4.5 0.63 8.9 4.5 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 AKNA PF12443.8 CCF43439.1 - 0.56 10.9 4.5 0.62 10.8 0.7 2.7 2 1 0 2 2 2 0 AT-hook-containing transcription factor Tropomyosin_1 PF12718.7 CCF43439.1 - 1.2 9.3 12.1 5 7.3 1.6 2.3 1 1 0 2 2 2 0 Tropomyosin like OEP PF02321.18 CCF43439.1 - 1.4 8.7 8.0 0.62 9.9 0.3 2.2 2 0 0 2 2 2 0 Outer membrane efflux protein Tropomyosin PF00261.20 CCF43439.1 - 2.5 7.4 10.2 5.7 6.2 2.7 2.1 1 1 1 2 2 2 0 Tropomyosin DUF16 PF01519.16 CCF43439.1 - 3.3 8.2 7.1 46 4.6 7.1 2.2 1 1 0 1 1 1 0 Protein of unknown function DUF16 YkyA PF10368.9 CCF43439.1 - 4.4 6.9 6.8 2.7 7.7 2.0 2.0 1 1 1 2 2 2 0 Putative cell-wall binding lipoprotein Spc7 PF08317.11 CCF43439.1 - 5.8 5.7 9.4 5 5.9 4.8 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein 3-PAP PF12578.8 CCF43439.1 - 7.6 6.3 7.4 4.6 7.0 1.6 2.9 2 1 2 4 4 3 0 Myotubularin-associated protein BTB PF00651.31 CCF43440.1 - 0.0001 22.5 0.8 0.00036 20.7 0.1 2.2 3 0 0 3 3 3 1 BTB/POZ domain Amidohydro_2 PF04909.14 CCF43441.1 - 2.4e-15 57.1 0.1 2.9e-15 56.8 0.1 1.0 1 0 0 1 1 1 1 Amidohydrolase DUF3587 PF12132.8 CCF43442.1 - 3.1 7.2 7.8 3.4 7.1 7.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3587) AMP-binding PF00501.28 CCF43444.1 - 1.8e-33 115.7 0.0 2.5e-33 115.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.12 CCF43444.1 - 1.1e-09 37.8 0.0 1.9e-09 37.0 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein PP-binding PF00550.25 CCF43444.1 - 1.4e-07 31.8 0.0 2.6e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 Phosphopantetheine attachment site Semialdhyde_dh PF01118.24 CCF43444.1 - 0.019 15.4 0.1 0.1 13.0 0.1 2.3 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain KR PF08659.10 CCF43444.1 - 0.1 12.5 0.1 0.18 11.7 0.1 1.3 1 0 0 1 1 1 0 KR domain Polysacc_synt_2 PF02719.15 CCF43444.1 - 0.14 11.2 0.0 0.22 10.6 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Carb_anhydrase PF00194.21 CCF43445.1 - 3.6e-35 121.7 0.0 4.8e-35 121.3 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Polyketide_cyc2 PF10604.9 CCF43446.1 - 2.1e-16 60.4 0.0 2.4e-16 60.3 0.0 1.0 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc PF03364.20 CCF43446.1 - 0.029 14.6 0.0 0.031 14.5 0.0 1.4 1 1 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport LptC PF06835.13 CCF43446.1 - 0.11 12.1 0.0 0.14 11.7 0.0 1.1 1 0 0 1 1 1 0 Lipopolysaccharide-assembly, LptC-related ANTAR PF03861.14 CCF43447.1 - 0.16 11.8 1.0 4.2 7.3 0.0 2.5 2 0 0 2 2 2 0 ANTAR domain PI-PLC-X PF00388.19 CCF43448.1 - 3.8e-64 214.6 0.0 5.5e-64 214.1 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 CCF43448.1 - 8.2e-09 35.8 0.0 1.4e-08 35.1 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain LRR_4 PF12799.7 CCF43450.1 - 1.1e-09 38.3 0.1 0.027 14.9 0.0 4.8 3 1 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 CCF43450.1 - 1.4e-09 37.2 9.0 0.061 13.4 0.0 6.9 8 0 0 8 8 8 3 Leucine Rich repeat LRR_1 PF00560.33 CCF43450.1 - 1.1e-06 28.3 9.7 3.4 8.6 0.0 7.5 8 0 0 8 8 8 2 Leucine Rich Repeat LRR_8 PF13855.6 CCF43450.1 - 0.0016 18.1 1.2 1.7 8.5 0.0 4.0 3 2 0 3 3 3 2 Leucine rich repeat SAM_Ste50p PF09235.10 CCF43450.1 - 0.025 14.8 0.7 1.2 9.5 0.0 3.3 4 0 0 4 4 4 0 Ste50p, sterile alpha motif MFS_1 PF07690.16 CCF43452.1 - 6.2e-27 94.4 31.4 6.2e-27 94.4 31.4 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily FAD_binding_4 PF01565.23 CCF43454.1 - 1.5e-28 99.3 1.8 2.2e-28 98.7 1.8 1.3 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 CCF43454.1 - 2.3e-13 50.0 0.0 4.4e-13 49.1 0.0 1.5 1 0 0 1 1 1 1 Berberine and berberine like Glyco_hydro_43 PF04616.14 CCF43455.1 - 1.1e-40 139.8 1.9 1.2e-40 139.6 1.9 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 APH PF01636.23 CCF43456.1 - 2.9e-06 27.4 0.0 3.7e-06 27.0 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CCF43456.1 - 0.066 12.8 0.1 0.1 12.2 0.1 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase Pkinase PF00069.25 CCF43456.1 - 0.19 11.1 0.0 0.26 10.6 0.0 1.2 1 0 0 1 1 1 0 Protein kinase domain NAD_binding_10 PF13460.6 CCF43457.1 - 5.4e-06 26.4 0.1 2.4e-05 24.3 0.1 2.0 1 1 0 1 1 1 1 NAD(P)H-binding Fungal_trans PF04082.18 CCF43458.1 - 3.8e-28 98.3 0.0 6.1e-28 97.6 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF43458.1 - 6.4e-07 29.4 7.2 1.1e-06 28.7 7.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Aspzincin_M35 PF14521.6 CCF43459.1 - 0.057 14.0 0.3 5.2 7.6 0.0 2.9 2 0 0 2 2 2 0 Lysine-specific metallo-endopeptidase Tannase PF07519.11 CCF43460.1 - 7.7e-90 302.0 0.0 9.1e-90 301.8 0.0 1.0 1 0 0 1 1 1 1 Tannase and feruloyl esterase Peptidase_S9 PF00326.21 CCF43460.1 - 0.017 14.6 0.0 0.54 9.7 0.0 2.1 2 0 0 2 2 2 0 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 CCF43460.1 - 0.076 12.6 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold NUDIX PF00293.28 CCF43461.1 - 0.004 17.2 0.0 0.0091 16.0 0.0 1.6 1 1 0 1 1 1 1 NUDIX domain Glyco_hydro_61 PF03443.14 CCF43462.1 - 6.6e-42 143.8 0.3 8.8e-42 143.4 0.3 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 TPR_12 PF13424.6 CCF43463.1 - 1.9e-14 53.7 0.9 0.00034 20.8 0.2 3.8 3 1 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 CCF43463.1 - 3e-08 33.2 1.5 9.2 6.7 0.5 6.7 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.6 CCF43463.1 - 2.6e-05 24.1 0.0 2.1 8.8 0.0 4.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_MalT PF17874.1 CCF43463.1 - 0.00036 20.0 0.2 0.27 10.6 0.1 2.4 2 0 0 2 2 2 2 MalT-like TPR region HET PF06985.11 CCF43463.1 - 0.0022 18.3 0.1 0.0057 17.0 0.1 1.7 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) TPR_1 PF00515.28 CCF43463.1 - 0.0031 17.3 0.0 24 4.9 0.0 5.2 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_10 PF13374.6 CCF43463.1 - 0.0085 15.9 3.4 3.2 7.8 0.0 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 CCF43463.1 - 0.039 14.0 0.0 42 4.5 0.1 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat Ank_4 PF13637.6 CCF43463.1 - 0.16 12.6 0.0 0.44 11.2 0.0 1.7 1 0 0 1 1 1 0 Ankyrin repeats (many copies) APG17 PF04108.12 CCF43464.1 - 0.015 14.4 3.7 0.023 13.8 2.0 1.7 1 1 1 2 2 2 0 Autophagy protein Apg17 Spidroin_N PF16763.5 CCF43464.1 - 0.17 11.9 9.0 7.6 6.6 8.1 2.6 1 1 0 1 1 1 0 Major ampullate spidroin 1, spider silk protein 1, N-term Baculo_PEP_C PF04513.12 CCF43464.1 - 0.23 11.5 13.6 2.6 8.1 13.3 2.4 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus MFS_1 PF07690.16 CCF43465.1 - 5.5e-20 71.6 14.5 6.9e-20 71.3 14.5 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily GrpE PF01025.19 CCF43466.1 - 1.6e-50 171.1 2.7 1.9e-50 170.7 2.7 1.1 1 0 0 1 1 1 1 GrpE IL2 PF00715.17 CCF43466.1 - 0.025 14.5 0.1 0.038 13.9 0.1 1.3 1 0 0 1 1 1 0 Interleukin 2 Phage_GPO PF05929.11 CCF43466.1 - 0.075 12.6 2.2 0.1 12.2 2.2 1.2 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase GPS2_interact PF15784.5 CCF43466.1 - 0.077 13.4 0.4 0.077 13.4 0.4 2.2 2 1 0 2 2 2 0 G-protein pathway suppressor 2-interacting domain RNA_pol_A_bac PF01000.26 CCF43467.1 - 1.1e-33 115.9 0.0 1.9e-33 115.2 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 CCF43467.1 - 3e-19 68.2 0.0 3.9e-19 67.8 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain PriA_CRR PF18319.1 CCF43467.1 - 0.044 13.8 1.7 0.15 12.1 1.7 2.0 1 0 0 1 1 1 0 PriA DNA helicase Cys-rich region (CRR) domain Sulfotransfer_4 PF17784.1 CCF43468.1 - 2.8e-54 184.2 0.0 3.7e-54 183.8 0.0 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 CCF43468.1 - 0.00069 20.1 1.8 0.52 10.7 0.3 2.6 1 1 0 2 2 2 2 Sulfotransferase family CENP-B_dimeris PF09026.10 CCF43469.1 - 1 9.8 7.9 3.7 8.0 0.8 2.2 2 0 0 2 2 2 0 Centromere protein B dimerisation domain UDPGT PF00201.18 CCF43473.1 - 1.5e-09 37.2 0.1 1.6e-09 37.1 0.1 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_trans_1_4 PF13692.6 CCF43473.1 - 8.5e-06 26.2 0.1 1.9e-05 25.1 0.0 1.7 1 1 1 2 2 2 1 Glycosyl transferases group 1 Glyco_tran_28_C PF04101.16 CCF43473.1 - 0.0039 17.2 0.0 0.0045 17.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain p450 PF00067.22 CCF43474.1 - 1.5e-32 113.0 0.0 1.7e-32 112.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 TAXi_C PF14541.6 CCF43474.1 - 0.031 14.1 0.0 0.049 13.4 0.0 1.3 1 0 0 1 1 1 0 Xylanase inhibitor C-terminal CN_hydrolase PF00795.22 CCF43475.1 - 9.4e-25 87.4 0.0 1.1e-24 87.2 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase HAD PF12710.7 CCF43476.1 - 0.00022 21.7 0.0 0.00066 20.1 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Methyltransf_23 PF13489.6 CCF43477.1 - 9.6e-20 71.1 0.0 1.5e-19 70.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF43477.1 - 1.6e-11 44.7 0.0 3.1e-11 43.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF43477.1 - 9.3e-10 38.5 0.0 1.9e-09 37.5 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF43477.1 - 4.5e-08 33.8 0.0 1.8e-07 31.8 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF43477.1 - 1.5e-07 32.0 0.0 3.1e-07 30.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CCF43477.1 - 0.0012 18.4 0.0 0.0022 17.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain FtsJ PF01728.19 CCF43477.1 - 0.0013 18.9 0.0 0.0022 18.1 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_4 PF02390.17 CCF43477.1 - 0.0045 16.5 0.0 0.011 15.2 0.0 1.6 2 0 0 2 2 2 1 Putative methyltransferase Ubie_methyltran PF01209.18 CCF43477.1 - 0.019 14.3 0.0 0.92 8.8 0.0 2.5 1 1 1 2 2 2 0 ubiE/COQ5 methyltransferase family CMAS PF02353.20 CCF43477.1 - 0.026 13.8 0.0 0.061 12.6 0.0 1.6 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase PrmA PF06325.13 CCF43477.1 - 0.043 13.2 0.0 0.12 11.7 0.0 1.7 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) PCMT PF01135.19 CCF43477.1 - 0.15 11.8 0.2 4.2 7.1 0.1 3.0 3 1 0 3 3 3 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) p450 PF00067.22 CCF43478.1 - 6.9e-62 209.7 0.0 9.3e-62 209.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 adh_short PF00106.25 CCF43479.1 - 1.7e-39 135.3 0.0 2.2e-39 135.0 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF43479.1 - 1e-21 77.6 0.0 1.3e-21 77.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF43479.1 - 4.4e-07 30.0 0.0 5.9e-07 29.6 0.0 1.2 1 0 0 1 1 1 1 KR domain F420_oxidored PF03807.17 CCF43479.1 - 9e-05 23.0 0.2 0.00018 22.0 0.2 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 CCF43479.1 - 0.00021 21.3 0.0 0.00039 20.5 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase 3HCDH_N PF02737.18 CCF43479.1 - 0.0035 17.2 0.1 0.0066 16.3 0.1 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Epimerase PF01370.21 CCF43479.1 - 0.0074 15.8 0.0 0.0097 15.4 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 CCF43479.1 - 0.0085 15.2 0.1 0.012 14.8 0.1 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_2 PF03446.15 CCF43479.1 - 0.0096 16.1 0.0 0.018 15.2 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase GDP_Man_Dehyd PF16363.5 CCF43479.1 - 0.015 14.7 0.2 0.045 13.1 0.2 1.7 1 1 1 2 2 2 0 GDP-mannose 4,6 dehydratase Sacchrp_dh_NADP PF03435.18 CCF43479.1 - 0.083 13.2 0.1 0.14 12.4 0.1 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Melibiase_2 PF16499.5 CCF43480.1 - 2.1e-46 158.4 0.6 4e-46 157.5 0.6 1.5 1 1 0 1 1 1 1 Alpha galactosidase A DUF905 PF06006.12 CCF43480.1 - 0.13 12.3 0.0 0.32 11.0 0.0 1.8 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF905) Peptidase_S8 PF00082.22 CCF43481.1 - 5.7e-45 153.8 4.3 8.8e-45 153.2 4.3 1.2 1 0 0 1 1 1 1 Subtilase family fn3_5 PF06280.12 CCF43481.1 - 1.2e-06 29.2 0.3 1e-05 26.2 0.0 2.4 2 0 0 2 2 2 1 Fn3-like domain PA PF02225.22 CCF43481.1 - 9.2e-05 22.4 0.0 0.00036 20.5 0.0 2.0 1 0 0 1 1 1 1 PA domain Spc24 PF08286.11 CCF43483.1 - 4.1e-24 84.8 0.0 4.2e-24 84.8 0.0 1.0 1 0 0 1 1 1 1 Spc24 subunit of Ndc80 ABC_tran PF00005.27 CCF43484.1 - 2.3e-19 70.2 0.6 4.3e-19 69.4 0.6 1.5 1 0 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.7 CCF43484.1 - 1.2e-15 57.5 1.7 2.3e-10 40.1 0.5 2.2 2 0 0 2 2 2 2 ABC-2 family transporter protein AAA_21 PF13304.6 CCF43484.1 - 3.1e-11 43.6 0.6 6.6e-05 22.9 0.7 2.3 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CCF43484.1 - 3.2e-05 23.5 0.2 0.079 12.4 0.0 2.3 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CCF43484.1 - 4.6e-05 23.1 0.1 0.00013 21.7 0.1 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 CCF43484.1 - 0.01 16.3 0.2 0.022 15.3 0.2 1.4 1 0 0 1 1 1 0 AAA domain Tail_VII PF17091.5 CCF43484.1 - 0.04 13.8 0.6 0.04 13.8 0.6 2.2 2 0 0 2 2 2 0 Inovirus G7P protein MASE2 PF05230.11 CCF43484.1 - 0.067 13.3 0.6 2.8 8.1 0.1 3.4 3 0 0 3 3 3 0 MASE2 domain AAA_16 PF13191.6 CCF43484.1 - 0.073 13.5 0.1 0.45 10.9 0.1 2.3 3 0 0 3 3 3 0 AAA ATPase domain AAA_15 PF13175.6 CCF43484.1 - 0.18 11.5 0.1 0.28 10.8 0.1 1.2 1 0 0 1 1 1 0 AAA ATPase domain GMC_oxred_C PF05199.13 CCF43486.1 - 3.3e-36 125.0 0.0 5e-36 124.4 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase MFS_1 PF07690.16 CCF43487.1 - 3.9e-10 39.2 8.7 3.9e-10 39.2 8.7 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF43487.1 - 6.6e-07 28.5 6.6 1.3e-06 27.6 6.6 1.5 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1_like PF12832.7 CCF43487.1 - 0.077 11.8 5.2 0.3 9.9 4.2 1.9 1 1 0 1 1 1 0 MFS_1 like family LacAB_rpiB PF02502.18 CCF43487.1 - 0.13 12.3 0.2 0.24 11.4 0.2 1.4 1 0 0 1 1 1 0 Ribose/Galactose Isomerase Tmemb_14 PF03647.13 CCF43487.1 - 1.6 9.5 8.4 0.18 12.5 0.8 2.7 2 1 1 3 3 3 0 Transmembrane proteins 14C PALP PF00291.25 CCF43490.1 - 2.3e-76 257.0 0.2 2.8e-76 256.8 0.2 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Thr_dehydrat_C PF00585.18 CCF43490.1 - 5.7e-41 138.2 0.0 7.9e-21 73.6 0.0 2.3 2 0 0 2 2 2 2 C-terminal regulatory domain of Threonine dehydratase p450 PF00067.22 CCF43491.1 - 5e-22 78.3 0.0 5.1e-22 78.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Helicase_C_3 PF13625.6 CCF43492.1 - 2.7e-33 114.8 0.0 4.1e-33 114.2 0.0 1.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCF43492.1 - 2.4e-05 24.4 0.0 4.9e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AChE_tetra PF08674.10 CCF43492.1 - 0.025 14.3 3.6 0.055 13.2 3.6 1.5 1 0 0 1 1 1 0 Acetylcholinesterase tetramerisation domain zf-CHY PF05495.12 CCF43493.1 - 9.7e-12 45.2 20.8 1.9e-11 44.3 20.8 1.5 1 0 0 1 1 1 1 CHY zinc finger RNA_POL_M_15KD PF02150.16 CCF43493.1 - 1 9.3 12.3 9.3 6.2 0.0 3.3 3 0 0 3 3 3 0 RNA polymerases M/15 Kd subunit zinc_ribbon_9 PF14369.6 CCF43493.1 - 1 9.7 10.3 0.74 10.1 7.1 2.4 1 1 1 2 2 2 0 zinc-ribbon Zn-ribbon_8 PF09723.10 CCF43493.1 - 1.1 9.4 16.5 3.3 7.9 9.1 2.6 1 1 1 2 2 2 0 Zinc ribbon domain HypA PF01155.19 CCF43493.1 - 1.3 9.0 13.0 0.051 13.6 4.3 2.1 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Proteasome PF00227.26 CCF43494.1 - 1.1e-55 188.0 0.1 1.7e-55 187.5 0.1 1.3 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 CCF43494.1 - 1.2e-11 44.0 0.4 3.7e-11 42.5 0.1 1.9 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature Zn_clus PF00172.18 CCF43495.1 - 7e-07 29.3 10.4 1.2e-06 28.5 10.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PSI_integrin PF17205.3 CCF43495.1 - 0.018 14.8 1.2 0.077 12.7 1.2 2.1 1 0 0 1 1 1 0 Integrin plexin domain FAD-oxidase_C PF02913.19 CCF43496.1 - 1.1e-62 211.9 0.0 1.6e-62 211.4 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 CCF43496.1 - 1.5e-38 131.7 0.4 2.8e-38 130.8 0.4 1.4 1 0 0 1 1 1 1 FAD binding domain Cu_bind_like PF02298.17 CCF43497.1 - 0.06 13.4 0.1 0.29 11.2 0.1 2.0 1 1 0 1 1 1 0 Plastocyanin-like domain Cupredoxin_1 PF13473.6 CCF43497.1 - 0.068 13.3 0.2 0.13 12.3 0.1 1.6 1 1 0 1 1 1 0 Cupredoxin-like domain GRP PF07172.11 CCF43497.1 - 0.11 13.1 14.7 0.28 11.9 14.7 1.6 1 0 0 1 1 1 0 Glycine rich protein family zf-LYAR PF08790.11 CCF43498.1 - 6.4e-15 54.8 2.1 1.3e-14 53.7 2.1 1.6 1 0 0 1 1 1 1 LYAR-type C2HC zinc finger Gemini_AL2 PF01440.16 CCF43498.1 - 0.046 14.2 0.3 0.046 14.2 0.3 2.1 2 0 0 2 2 2 0 Geminivirus AL2 protein Ferlin_C PF16165.5 CCF43498.1 - 0.28 11.1 0.9 8.5 6.3 0.1 2.1 2 0 0 2 2 2 0 Ferlin C-terminus RmlD_sub_bind PF04321.17 CCF43499.1 - 2.9e-54 184.1 0.0 3.5e-54 183.9 0.0 1.0 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.21 CCF43499.1 - 3.2e-21 75.9 0.0 5.8e-21 75.0 0.0 1.4 1 1 1 2 2 2 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CCF43499.1 - 2.1e-12 47.1 0.0 4e-12 46.2 0.0 1.6 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 CCF43499.1 - 9.4e-12 44.6 0.0 5.5e-10 38.9 0.0 2.2 2 0 0 2 2 2 1 Male sterility protein Polysacc_synt_2 PF02719.15 CCF43499.1 - 1.6e-07 30.8 0.5 2.4e-05 23.6 0.5 2.9 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 CCF43499.1 - 4.7e-06 25.8 0.0 1.8e-05 23.9 0.0 1.7 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family KR PF08659.10 CCF43499.1 - 0.073 13.0 0.5 14 5.5 0.0 2.5 2 1 1 3 3 3 0 KR domain NmrA PF05368.13 CCF43499.1 - 0.15 11.6 0.3 1.8 8.0 0.1 2.2 2 0 0 2 2 2 0 NmrA-like family Ammonium_transp PF00909.21 CCF43500.1 - 1.4e-116 389.5 30.8 1.6e-116 389.3 30.8 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family DUF3185 PF11381.8 CCF43500.1 - 4.4 7.4 9.1 9 6.4 0.1 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3185) Abhydrolase_4 PF08386.10 CCF43501.1 - 2.5e-14 53.3 0.0 4.9e-14 52.3 0.0 1.5 2 0 0 2 2 2 1 TAP-like protein Peptidase_S9 PF00326.21 CCF43501.1 - 0.14 11.6 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family EF_assoc_2 PF08356.12 CCF43503.1 - 5.8e-35 119.2 0.0 1.2e-34 118.2 0.0 1.5 1 0 0 1 1 1 1 EF hand associated EF_assoc_1 PF08355.12 CCF43503.1 - 3e-31 106.8 1.6 6.2e-31 105.8 1.6 1.5 1 0 0 1 1 1 1 EF hand associated Ras PF00071.22 CCF43503.1 - 1.6e-12 47.3 0.0 4.9e-06 26.2 0.0 2.2 2 0 0 2 2 2 2 Ras family EF-hand_1 PF00036.32 CCF43503.1 - 2.7e-08 32.8 2.9 0.0036 16.7 0.0 2.8 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 CCF43503.1 - 3.7e-07 30.5 0.3 0.00072 20.0 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 CCF43503.1 - 1.6e-06 27.6 4.6 0.018 14.9 0.3 2.9 2 1 0 2 2 2 2 EF-hand domain Roc PF08477.13 CCF43503.1 - 5.9e-05 23.3 0.0 0.029 14.6 0.0 2.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase EF-hand_5 PF13202.6 CCF43503.1 - 0.00018 20.8 5.2 0.26 10.9 2.7 2.7 2 0 0 2 2 2 2 EF hand AAA_29 PF13555.6 CCF43503.1 - 0.0023 17.7 0.0 0.0051 16.5 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 CCF43503.1 - 0.004 17.5 0.0 0.0084 16.5 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain EF-hand_10 PF14788.6 CCF43503.1 - 0.011 15.6 1.6 0.18 11.7 0.1 2.5 2 0 0 2 2 2 0 EF hand RsgA_GTPase PF03193.16 CCF43503.1 - 0.012 15.5 0.0 0.3 11.0 0.0 2.5 2 0 0 2 2 2 0 RsgA GTPase EF-hand_8 PF13833.6 CCF43503.1 - 0.014 15.2 4.0 0.94 9.4 0.1 2.5 2 0 0 2 2 2 0 EF-hand domain pair SPARC_Ca_bdg PF10591.9 CCF43503.1 - 0.044 14.1 0.1 1.7 9.0 0.1 2.8 3 0 0 3 3 2 0 Secreted protein acidic and rich in cysteine Ca binding region MMR_HSR1 PF01926.23 CCF43503.1 - 0.11 12.6 0.0 0.6 10.2 0.0 2.3 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_22 PF13401.6 CCF43503.1 - 0.11 12.7 0.0 0.25 11.6 0.0 1.7 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CCF43503.1 - 0.16 12.5 0.0 0.33 11.5 0.0 1.5 1 0 0 1 1 1 0 ABC transporter RRM_1 PF00076.22 CCF43506.1 - 1.1e-43 146.9 0.6 8.7e-20 70.3 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM39linker PF15519.6 CCF43506.1 - 4.5e-23 82.1 0.1 1.5e-22 80.4 0.1 2.0 1 0 0 1 1 1 1 linker between RRM2 and RRM3 domains in RBM39 protein RRM_occluded PF16842.5 CCF43506.1 - 0.0012 18.7 0.0 0.28 11.1 0.0 3.1 3 0 0 3 3 3 1 Occluded RNA-recognition motif RRM_3 PF08777.11 CCF43506.1 - 0.0018 18.3 0.5 0.099 12.7 0.0 2.9 3 0 0 3 3 3 1 RNA binding motif Nup35_RRM_2 PF14605.6 CCF43506.1 - 0.0021 18.0 0.0 0.3 11.1 0.0 2.8 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 CCF43506.1 - 0.014 15.5 0.0 1.7 8.8 0.0 2.6 2 0 0 2 2 2 0 RNA recognition motif PHM7_cyt PF14703.6 CCF43506.1 - 0.028 14.7 0.2 0.96 9.7 0.2 3.1 1 1 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter Cyt-b5 PF00173.28 CCF43507.1 - 1.9e-17 63.2 1.2 5.4e-17 61.7 0.1 2.2 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain FA_hydroxylase PF04116.13 CCF43507.1 - 3.7e-11 43.5 18.8 3.7e-11 43.5 18.8 1.6 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Anth_synt_I_N PF04715.13 CCF43507.1 - 0.0048 17.1 0.1 0.0093 16.2 0.1 1.4 1 0 0 1 1 1 1 Anthranilate synthase component I, N terminal region ATP-synt_I PF03899.15 CCF43507.1 - 0.54 10.7 3.3 1.6 9.1 1.0 2.1 2 0 0 2 2 2 0 ATP synthase I chain Het-C PF07217.11 CCF43508.1 - 1.5e-173 578.4 0.0 1.7e-173 578.2 0.0 1.0 1 0 0 1 1 1 1 Heterokaryon incompatibility protein Het-C CBP PF12192.8 CCF43508.1 - 0.13 12.5 0.1 0.64 10.2 0.1 1.9 1 1 0 1 1 1 0 Fungal calcium binding protein Fungal_trans_2 PF11951.8 CCF43509.1 - 4.4e-25 88.3 11.0 1.6e-20 73.3 2.0 2.5 3 0 0 3 3 3 2 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF43509.1 - 0.00014 21.9 1.8 0.00022 21.2 1.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Suf PF05843.14 CCF43509.1 - 0.038 14.0 6.1 0.062 13.3 6.1 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) RR_TM4-6 PF06459.12 CCF43509.1 - 0.08 12.8 5.8 0.13 12.1 5.8 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SR-25 PF10500.9 CCF43509.1 - 2.8 7.5 19.9 0.88 9.1 0.8 2.3 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Spt20 PF12090.8 CCF43509.1 - 7.2 6.1 12.1 15 5.1 12.1 1.4 1 0 0 1 1 1 0 Spt20 family Presenilin PF01080.17 CCF43509.1 - 9 4.9 9.6 15 4.2 9.6 1.3 1 0 0 1 1 1 0 Presenilin EutQ PF06249.12 CCF43510.1 - 1.1e-12 47.9 0.0 1.4e-12 47.6 0.0 1.0 1 0 0 1 1 1 1 Ethanolamine utilisation protein EutQ Cupin_3 PF05899.12 CCF43510.1 - 1.7e-11 43.6 0.1 3.4e-11 42.7 0.0 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF861) Cupin_2 PF07883.11 CCF43510.1 - 3.1e-05 23.6 0.0 4.8e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Cupin domain KduI PF04962.12 CCF43510.1 - 0.0057 16.0 0.0 0.0061 15.9 0.0 1.1 1 0 0 1 1 1 1 KduI/IolB family Cupin_1 PF00190.22 CCF43510.1 - 0.015 14.9 0.0 0.021 14.4 0.0 1.3 1 0 0 1 1 1 0 Cupin Pirin PF02678.16 CCF43510.1 - 0.033 14.2 0.0 0.04 13.9 0.0 1.3 1 1 0 1 1 1 0 Pirin Cupin_6 PF12852.7 CCF43510.1 - 0.097 12.4 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 Cupin DUF16 PF01519.16 CCF43512.1 - 0.36 11.3 4.1 0.44 11.1 4.1 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF16 SlyX PF04102.12 CCF43512.1 - 1.5 9.5 6.3 48 4.7 6.5 2.2 1 1 0 1 1 1 0 SlyX PIF1 PF05970.14 CCF43513.1 - 1.2e-31 110.3 0.6 2.6e-28 99.2 0.1 3.3 2 1 1 3 3 3 2 PIF1-like helicase AAA_30 PF13604.6 CCF43513.1 - 1.7e-15 57.2 0.0 4.2e-13 49.4 0.0 2.3 2 0 0 2 2 2 1 AAA domain Cauli_VI PF01693.16 CCF43513.1 - 1.3e-13 51.0 2.6 2.5e-13 50.1 2.6 1.5 1 0 0 1 1 1 1 Caulimovirus viroplasmin AAA_19 PF13245.6 CCF43513.1 - 1.3e-10 41.8 0.0 2.4e-10 40.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CCF43513.1 - 1e-05 26.0 0.0 0.00014 22.3 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 CCF43513.1 - 1.2e-05 25.3 0.0 2.1e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 CCF43513.1 - 3.2e-05 24.2 0.1 0.00015 22.0 0.1 2.1 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 CCF43513.1 - 0.00019 21.9 0.0 0.00031 21.2 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 CCF43513.1 - 0.00057 19.9 0.0 0.0018 18.3 0.0 1.8 1 1 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 CCF43513.1 - 0.0028 17.1 0.1 0.007 15.8 0.1 1.7 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 CCF43513.1 - 0.0039 16.9 0.7 2.1 8.0 0.0 2.3 1 1 1 2 2 2 2 IstB-like ATP binding protein ABC_tran PF00005.27 CCF43513.1 - 0.008 16.7 0.0 0.02 15.4 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_29 PF13555.6 CCF43513.1 - 0.0081 15.9 0.0 0.019 14.7 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain NB-ARC PF00931.22 CCF43513.1 - 0.013 14.7 0.1 0.022 14.0 0.1 1.2 1 0 0 1 1 1 0 NB-ARC domain ATPase_2 PF01637.18 CCF43513.1 - 0.013 15.4 0.1 0.041 13.8 0.1 1.7 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea Sigma54_activat PF00158.26 CCF43513.1 - 0.017 14.9 0.1 0.059 13.1 0.1 1.8 1 1 0 1 1 1 0 Sigma-54 interaction domain Viral_helicase1 PF01443.18 CCF43513.1 - 0.018 14.8 0.1 0.055 13.2 0.1 1.8 1 1 0 1 1 1 0 Viral (Superfamily 1) RNA helicase DEAD PF00270.29 CCF43513.1 - 0.02 14.6 0.1 7 6.4 0.1 2.3 2 0 0 2 2 2 0 DEAD/DEAH box helicase NTPase_1 PF03266.15 CCF43513.1 - 0.021 14.7 0.3 0.84 9.5 0.1 2.3 2 0 0 2 2 2 0 NTPase DUF815 PF05673.13 CCF43513.1 - 0.021 14.0 0.1 0.038 13.2 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) RNA_helicase PF00910.22 CCF43513.1 - 0.022 15.1 0.7 0.085 13.2 0.1 2.2 2 1 0 2 2 2 0 RNA helicase AAA_10 PF12846.7 CCF43513.1 - 0.046 12.6 0.0 0.068 12.1 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain AAA_24 PF13479.6 CCF43513.1 - 0.051 13.3 0.0 0.08 12.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 CCF43513.1 - 0.072 12.6 0.1 0.73 9.3 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region ATP-synt_ab PF00006.25 CCF43513.1 - 0.11 12.1 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain Zeta_toxin PF06414.12 CCF43513.1 - 0.12 11.7 0.1 0.23 10.7 0.1 1.4 1 0 0 1 1 1 0 Zeta toxin T2SSE PF00437.20 CCF43513.1 - 0.13 11.3 0.0 0.22 10.5 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein APS_kinase PF01583.20 CCF43513.1 - 0.14 12.0 0.2 0.41 10.5 0.0 1.8 2 0 0 2 2 2 0 Adenylylsulphate kinase Rad17 PF03215.15 CCF43513.1 - 0.17 11.8 0.1 0.36 10.7 0.1 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain MeaB PF03308.16 CCF43513.1 - 0.24 10.4 0.1 0.38 9.7 0.1 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB SH3_1 PF00018.28 CCF43514.1 - 2.5e-09 36.6 0.4 5e-09 35.6 0.1 1.7 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 CCF43514.1 - 5e-07 29.5 0.0 1.1e-06 28.3 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 CCF43514.1 - 1.1e-05 25.0 0.0 2e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain DMT_YdcZ PF04657.13 CCF43514.1 - 1.1 9.5 12.8 1.8 8.8 12.8 1.2 1 0 0 1 1 1 0 Putative inner membrane exporter, YdcZ DUF2417 PF10329.9 CCF43514.1 - 4 6.8 11.0 8.1 5.8 11.0 1.5 1 1 0 1 1 1 0 Region of unknown function (DUF2417) MpPF26 PF07666.11 CCF43514.1 - 7.9 6.6 9.1 1.2 9.3 1.7 2.1 1 1 1 2 2 2 0 M penetrans paralogue family 26 DASH_Spc19 PF08287.11 CCF43515.1 - 1.3e-19 70.7 1.4 1.8e-19 70.2 1.4 1.2 1 0 0 1 1 1 1 Spc19 SlyX PF04102.12 CCF43515.1 - 0.019 15.6 1.5 0.042 14.5 0.2 2.0 2 0 0 2 2 2 0 SlyX GPS2_interact PF15784.5 CCF43515.1 - 0.092 13.2 1.1 0.13 12.7 0.2 1.6 1 1 1 2 2 2 0 G-protein pathway suppressor 2-interacting domain Spermine_synth PF01564.17 CCF43517.1 - 5.7e-06 25.9 0.0 1.8e-05 24.2 0.0 1.8 2 0 0 2 2 2 1 Spermine/spermidine synthase domain Methyltransf_23 PF13489.6 CCF43517.1 - 1.6e-05 24.8 0.0 3.6e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF43517.1 - 0.023 15.4 0.0 0.049 14.3 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.12 CCF43517.1 - 0.051 14.2 0.0 0.14 12.8 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain NPL4 PF05021.15 CCF43518.1 - 2.8e-138 460.4 0.0 4e-138 460.0 0.0 1.2 1 0 0 1 1 1 1 NPL4 family zf-NPL4 PF05020.15 CCF43518.1 - 2.8e-68 228.6 0.1 4.7e-68 227.9 0.1 1.4 1 0 0 1 1 1 1 NPL4 family, putative zinc binding region UN_NPL4 PF11543.8 CCF43518.1 - 0.0054 17.2 0.0 0.037 14.5 0.0 2.2 1 1 0 1 1 1 1 Nuclear pore localisation protein NPL4 Sec66 PF09802.9 CCF43519.1 - 1.1e-80 269.5 0.5 1.3e-80 269.3 0.5 1.0 1 0 0 1 1 1 1 Preprotein translocase subunit Sec66 DUF3848 PF12959.7 CCF43519.1 - 0.029 14.4 0.0 0.071 13.2 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3848) DUF4758 PF15950.5 CCF43519.1 - 0.12 12.8 0.4 0.2 12.0 0.4 1.4 1 0 0 1 1 1 0 Putative sperm flagellar membrane protein ORC3_N PF07034.11 CCF43521.1 - 1.3e-37 129.7 4.2 5.1e-21 75.1 0.6 2.2 1 1 1 2 2 2 2 Origin recognition complex (ORC) subunit 3 N-terminus ORC_WH_C PF18137.1 CCF43521.1 - 2.9e-25 89.0 0.2 1.1e-22 80.7 0.2 2.7 1 1 0 1 1 1 1 Origin recognition complex winged helix C-terminal ADH_N PF08240.12 CCF43523.1 - 1.6e-26 92.3 0.5 2e-26 92.0 0.5 1.1 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_N_assoc PF13823.6 CCF43523.1 - 6.2e-07 29.2 0.4 1.1e-06 28.5 0.4 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-associated Peptidase_S8 PF00082.22 CCF43524.1 - 5e-27 94.9 10.4 6.6e-27 94.5 10.4 1.2 1 0 0 1 1 1 1 Subtilase family ORMDL PF04061.14 CCF43525.1 - 2e-58 196.1 3.1 2.6e-58 195.7 3.1 1.2 1 0 0 1 1 1 1 ORMDL family zf-MYND PF01753.18 CCF43527.1 - 1.5e-06 28.2 9.1 4.1e-06 26.8 9.1 1.8 1 0 0 1 1 1 1 MYND finger zf-C6H2 PF15801.5 CCF43527.1 - 0.93 9.8 6.5 0.28 11.5 1.7 2.4 2 0 0 2 2 2 0 zf-MYND-like zinc finger, mRNA-binding PRELI PF04707.14 CCF43528.1 - 1.8e-19 70.1 0.0 4.5e-16 59.1 0.0 2.2 2 0 0 2 2 2 2 PRELI-like family HAV_VP PF12944.7 CCF43529.1 - 0.093 12.7 0.0 0.11 12.4 0.0 1.1 1 0 0 1 1 1 0 Hepatitis A virus viral protein VP DUF1996 PF09362.10 CCF43532.1 - 5.1e-23 82.3 0.1 6.2e-23 82.0 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) DUF1996 PF09362.10 CCF43533.1 - 9.4e-17 61.8 0.2 1.1e-16 61.5 0.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) Ras PF00071.22 CCF43534.1 - 4e-47 159.8 0.0 4.7e-47 159.6 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCF43534.1 - 3.2e-20 72.5 0.0 5e-20 71.9 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCF43534.1 - 1.1e-05 24.9 0.0 1.7e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 CCF43534.1 - 0.015 14.7 0.0 0.023 14.1 0.0 1.4 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit PduV-EutP PF10662.9 CCF43534.1 - 0.089 12.5 0.0 1.6 8.5 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Gtr1_RagA PF04670.12 CCF43534.1 - 0.2 11.0 0.0 0.28 10.5 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Chs7 PF12271.8 CCF43535.1 - 3.7e-111 371.1 5.7 4.2e-111 370.9 5.7 1.0 1 0 0 1 1 1 1 Chitin synthase export chaperone Herpes_UL20 PF04544.12 CCF43535.1 - 0.02 15.3 0.3 0.02 15.3 0.3 2.3 2 1 1 3 3 3 0 Herpesvirus egress protein UL20 MpPF26 PF07666.11 CCF43535.1 - 8.6 6.5 16.1 0.26 11.4 2.8 3.7 3 1 1 4 4 4 0 M penetrans paralogue family 26 Cytochrom_B561 PF03188.16 CCF43536.1 - 4.3e-17 62.5 2.5 4.3e-17 62.5 2.5 1.8 3 0 0 3 3 3 1 Eukaryotic cytochrome b561 DUF2162 PF09930.9 CCF43536.1 - 3.3e-05 23.4 9.6 0.032 13.7 4.4 2.1 2 0 0 2 2 2 2 Predicted transporter (DUF2162) DUF4006 PF13179.6 CCF43536.1 - 0.00015 21.6 0.2 0.039 13.9 0.3 2.9 2 0 0 2 2 2 1 Family of unknown function (DUF4006) Ni_hydr_CYTB PF01292.20 CCF43536.1 - 0.00041 20.0 10.8 0.01 15.5 2.5 2.5 1 1 1 2 2 2 2 Prokaryotic cytochrome b561 DUF4079 PF13301.6 CCF43536.1 - 0.0068 16.6 16.7 0.71 10.0 2.1 3.4 1 1 1 3 3 3 3 Protein of unknown function (DUF4079) DUF4271 PF14093.6 CCF43536.1 - 0.0072 16.3 5.2 0.01 15.8 5.0 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4271) PepSY_TM PF03929.16 CCF43536.1 - 0.048 13.3 11.0 0.039 13.6 1.9 2.5 1 1 1 2 2 2 0 PepSY-associated TM region DUF998 PF06197.13 CCF43536.1 - 0.097 12.3 15.1 0.46 10.1 4.3 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF998) DUF2347 PF09804.9 CCF43536.1 - 0.1 12.1 0.0 0.15 11.6 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) DUF420 PF04238.12 CCF43536.1 - 0.54 10.6 11.0 0.063 13.6 6.3 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF420) DUF4149 PF13664.6 CCF43536.1 - 7.3 7.0 13.8 1.1 9.6 3.8 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4149) Allantoicase PF03561.15 CCF43537.1 - 4.4e-96 318.6 0.1 2.1e-47 160.7 0.0 2.1 2 0 0 2 2 2 2 Allantoicase repeat DIL PF01843.19 CCF43538.1 - 1.3e-32 112.1 0.3 2.6e-32 111.2 0.3 1.5 1 0 0 1 1 1 1 DIL domain Ank_2 PF12796.7 CCF43538.1 - 3e-11 43.7 0.0 1.2e-10 41.9 0.0 2.0 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CCF43538.1 - 3.7e-10 40.1 0.1 3.1e-07 30.8 0.0 4.1 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 CCF43538.1 - 2.3e-09 37.3 0.3 0.004 17.6 0.0 4.3 5 0 0 5 5 5 2 Ankyrin repeat Ank_5 PF13857.6 CCF43538.1 - 1e-08 35.3 0.0 5.3e-06 26.6 0.0 2.8 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCF43538.1 - 3.3e-06 27.0 0.0 0.045 14.3 0.0 3.8 3 0 0 3 3 3 2 Ankyrin repeat Cys_Met_Meta_PP PF01053.20 CCF43539.1 - 8.2e-138 459.1 0.1 9.4e-138 458.9 0.1 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 CCF43539.1 - 8.9e-07 28.4 0.0 2.1e-06 27.1 0.0 1.5 2 0 0 2 2 2 1 Aminotransferase class I and II Aminotran_5 PF00266.19 CCF43539.1 - 8.5e-06 25.0 0.1 2.5e-05 23.4 0.1 1.7 2 0 0 2 2 2 1 Aminotransferase class-V Met_gamma_lyase PF06838.11 CCF43539.1 - 2.2e-05 23.2 0.2 6.4e-05 21.6 0.2 1.6 1 1 0 1 1 1 1 Methionine gamma-lyase DegT_DnrJ_EryC1 PF01041.17 CCF43539.1 - 0.00066 19.1 0.1 0.0024 17.2 0.0 1.8 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family ADH_zinc_N PF00107.26 CCF43541.1 - 5.8e-27 94.2 0.1 9.2e-27 93.6 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCF43541.1 - 1.6e-21 77.8 0.0 3.2e-21 76.8 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCF43541.1 - 2.3e-09 37.1 0.1 7.9e-09 35.4 0.0 2.0 2 1 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain AlaDh_PNT_C PF01262.21 CCF43541.1 - 0.019 14.2 0.3 0.03 13.6 0.3 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain ADH_N_2 PF16884.5 CCF43541.1 - 0.12 12.3 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 N-terminal domain of oxidoreductase Smg4_UPF3 PF03467.15 CCF43542.1 - 1.1e-47 162.3 0.0 1.1e-47 162.3 0.0 3.9 4 2 0 4 4 4 1 Smg-4/UPF3 family RRM_1 PF00076.22 CCF43542.1 - 1e-06 28.4 0.0 0.00023 20.9 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Glyco_hydro_44 PF12891.7 CCF43542.1 - 0.092 12.7 5.4 0.43 10.5 5.4 2.1 1 0 0 1 1 1 0 Glycoside hydrolase family 44 NUDIX PF00293.28 CCF43543.1 - 0.00015 21.8 0.2 0.0014 18.7 0.2 2.5 1 1 0 1 1 1 1 NUDIX domain BCIP PF13862.6 CCF43544.1 - 4.7e-68 229.0 0.1 6.1e-68 228.7 0.1 1.1 1 0 0 1 1 1 1 p21-C-terminal region-binding protein CM_2 PF01817.21 CCF43545.1 - 0.027 14.8 0.5 12 6.3 0.1 2.9 2 2 0 2 2 2 0 Chorismate mutase type II Zn_clus PF00172.18 CCF43546.1 - 0.00056 20.0 1.5 0.0012 18.9 1.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 CCF43546.1 - 0.1 11.4 0.0 0.5 9.1 0.0 2.0 3 0 0 3 3 3 0 Fungal specific transcription factor domain Asp PF00026.23 CCF43548.1 - 1.1e-72 245.1 4.3 1.4e-72 244.8 4.3 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCF43548.1 - 8.1e-14 52.2 6.5 3.7e-12 46.9 4.1 3.6 2 2 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 CCF43548.1 - 3.2e-07 30.9 0.9 0.022 15.4 0.2 3.7 2 1 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.6 CCF43548.1 - 0.0012 19.4 0.1 4.1 8.0 0.0 3.8 2 2 0 2 2 2 2 gag-polyprotein putative aspartyl protease TAXi_C PF14541.6 CCF43548.1 - 0.0049 16.7 0.0 0.021 14.6 0.0 2.0 2 0 0 2 2 2 1 Xylanase inhibitor C-terminal GGACT PF06094.12 CCF43549.1 - 2.4e-06 28.1 0.0 6.5e-06 26.8 0.0 1.7 1 1 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like AIG2_2 PF13772.6 CCF43549.1 - 6.9e-06 26.4 0.0 0.0062 16.9 0.0 2.3 2 0 0 2 2 2 2 AIG2-like family GMC_oxred_N PF00732.19 CCF43551.1 - 5.9e-57 193.3 0.0 7.9e-57 192.9 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCF43551.1 - 2.6e-37 128.5 0.0 5.4e-37 127.5 0.0 1.6 1 0 0 1 1 1 1 GMC oxidoreductase NAD_binding_8 PF13450.6 CCF43551.1 - 0.00089 19.4 0.0 0.0023 18.1 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CCF43551.1 - 0.0021 17.3 0.5 0.35 10.1 0.1 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCF43551.1 - 0.0053 16.4 0.0 0.19 11.3 0.0 2.4 2 0 0 2 2 2 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 CCF43551.1 - 0.048 12.7 0.6 0.34 9.9 0.3 2.0 2 0 0 2 2 2 0 Lycopene cyclase protein GIDA PF01134.22 CCF43551.1 - 0.065 12.3 0.3 4 6.4 0.0 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A Myosin_TH1 PF06017.13 CCF43552.1 - 1.8e-19 70.2 0.0 3.4e-19 69.2 0.0 1.4 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding SH3_1 PF00018.28 CCF43552.1 - 4.8e-14 51.7 0.2 9.7e-14 50.7 0.2 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 CCF43552.1 - 2.5e-12 46.4 0.1 6.9e-12 45.0 0.1 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 CCF43552.1 - 2.4e-09 36.7 0.0 8e-09 35.1 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_3 PF08239.11 CCF43552.1 - 0.04 14.2 0.2 0.085 13.1 0.2 1.5 1 0 0 1 1 1 0 Bacterial SH3 domain DUF4859 PF16151.5 CCF43552.1 - 0.14 12.0 0.3 0.49 10.3 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4859) EAR PF07897.11 CCF43552.1 - 0.17 11.5 0.6 0.44 10.2 0.6 1.6 1 0 0 1 1 1 0 Ethylene-responsive binding factor-associated repression DHHC PF01529.20 CCF43553.1 - 1.3e-14 54.4 4.4 1.7e-14 54.1 4.4 1.1 1 0 0 1 1 1 1 DHHC palmitoyltransferase NAD_binding_8 PF13450.6 CCF43554.1 - 8.2e-11 42.0 0.0 9.4e-11 41.8 0.0 1.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 CCF43554.1 - 1.1e-05 24.8 0.0 1.4e-05 24.5 0.0 1.1 1 0 0 1 1 1 1 Thi4 family DAO PF01266.24 CCF43554.1 - 0.0004 20.1 0.0 0.00044 19.9 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Amino_oxidase PF01593.24 CCF43554.1 - 0.0073 15.6 0.0 0.0079 15.5 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase FAD_oxidored PF12831.7 CCF43554.1 - 0.01 15.2 0.0 0.01 15.2 0.0 1.1 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCF43554.1 - 0.044 13.0 0.0 0.044 13.0 0.0 1.0 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 CCF43554.1 - 0.099 11.7 0.0 0.1 11.6 0.0 1.0 1 0 0 1 1 1 0 Lycopene cyclase protein FAD_binding_8 PF08022.12 CCF43555.1 - 9e-18 64.4 0.0 1.8e-17 63.4 0.0 1.5 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.19 CCF43555.1 - 7.4e-13 48.7 4.8 7.4e-13 48.7 4.8 2.0 1 1 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 CCF43555.1 - 1.2e-08 35.3 0.1 2.3e-05 24.6 0.0 3.1 2 1 0 2 2 2 2 Ferric reductase NAD binding domain EF-hand_7 PF13499.6 CCF43555.1 - 0.0062 17.0 0.5 0.028 14.9 0.5 2.0 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 CCF43555.1 - 0.047 13.6 0.5 0.14 12.2 0.5 1.8 1 0 0 1 1 1 0 EF-hand domain DUF308 PF03729.13 CCF43555.1 - 0.1 13.0 3.6 0.32 11.4 3.6 1.8 1 0 0 1 1 1 0 Short repeat of unknown function (DUF308) EF-hand_8 PF13833.6 CCF43555.1 - 0.17 11.7 0.5 0.39 10.6 0.5 1.5 1 0 0 1 1 1 0 EF-hand domain pair COesterase PF00135.28 CCF43556.1 - 2.4e-77 261.0 0.0 3.3e-77 260.5 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CCF43556.1 - 1.2e-05 25.3 0.3 4.3e-05 23.5 0.3 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold DUF3455 PF11937.8 CCF43559.1 - 6.6e-36 124.1 0.0 8.7e-36 123.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3455) DUF2990 PF11693.8 CCF43559.1 - 0.00045 20.3 0.8 0.0015 18.7 0.4 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2990) Tyrosinase PF00264.20 CCF43561.1 - 1.3e-50 172.8 0.0 2.1e-50 172.1 0.0 1.3 1 0 0 1 1 1 1 Common central domain of tyrosinase DEAD PF00270.29 CCF43562.1 - 0.053 13.3 0.0 0.089 12.6 0.0 1.3 1 0 0 1 1 1 0 DEAD/DEAH box helicase DUF410 PF04190.13 CCF43563.1 - 1.3e-65 221.8 0.0 1.4e-65 221.6 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF410) DUF3368 PF11848.8 CCF43563.1 - 0.029 14.1 0.0 0.059 13.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3368) Glyco_hydro_61 PF03443.14 CCF43564.1 - 1.2e-10 41.7 0.0 1.4e-10 41.5 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 Ldi PF18566.1 CCF43565.1 - 2.7e-46 158.5 0.0 3.4e-46 158.2 0.0 1.1 1 0 0 1 1 1 1 Linalool dehydratase/isomerase HepII_C PF18675.1 CCF43565.1 - 0.15 12.2 0.1 0.3 11.2 0.1 1.4 1 0 0 1 1 1 0 Heparinase II C-terminal domain Sugar_tr PF00083.24 CCF43566.1 - 7.4e-46 156.9 14.3 9e-46 156.6 14.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF43566.1 - 6.7e-07 28.5 23.5 2.6e-06 26.6 23.8 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily ABC2_membrane_5 PF13346.6 CCF43566.1 - 0.0032 17.1 10.1 0.0032 17.1 10.1 1.7 2 0 0 2 2 2 1 ABC-2 family transporter protein DUF3021 PF11457.8 CCF43566.1 - 0.01 16.2 10.1 0.01 16.2 10.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3021) RSN1_TM PF13967.6 CCF43566.1 - 0.14 11.9 3.6 0.16 11.8 1.6 2.0 2 0 0 2 2 2 0 Late exocytosis, associated with Golgi transport DUF21 PF01595.20 CCF43566.1 - 0.7 9.6 3.7 1.5 8.5 3.7 1.5 1 0 0 1 1 1 0 Cyclin M transmembrane N-terminal domain Amastin PF07344.11 CCF43566.1 - 3.6 7.4 11.9 3.4 7.5 7.6 2.3 1 1 1 2 2 2 0 Amastin surface glycoprotein ADH_zinc_N PF00107.26 CCF43567.1 - 7.4e-13 48.6 0.1 1.5e-12 47.6 0.0 1.5 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCF43567.1 - 3.6e-08 34.5 0.0 6.4e-08 33.7 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCF43567.1 - 1.2e-06 28.3 2.2 5.5e-06 26.2 1.2 2.0 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain Dynamin_N PF00350.23 CCF43568.1 - 2.6e-13 50.4 3.8 2.4e-12 47.3 0.0 3.7 3 1 0 3 3 3 1 Dynamin family MMR_HSR1 PF01926.23 CCF43568.1 - 3.8e-05 23.8 0.0 0.00062 19.8 0.0 3.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.27 CCF43568.1 - 0.00087 19.8 1.5 0.0034 17.9 0.0 2.6 2 1 0 2 2 2 1 ABC transporter RsgA_GTPase PF03193.16 CCF43568.1 - 0.002 18.1 0.1 0.01 15.7 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase IIGP PF05049.13 CCF43568.1 - 0.015 14.4 0.2 0.079 12.0 0.0 2.3 2 0 0 2 2 2 0 Interferon-inducible GTPase (IIGP) AAA_16 PF13191.6 CCF43568.1 - 0.023 15.1 0.3 0.61 10.4 0.0 3.2 3 0 0 3 3 3 0 AAA ATPase domain AAA_22 PF13401.6 CCF43568.1 - 0.031 14.6 0.2 4.9 7.4 0.0 3.7 4 0 0 4 4 4 0 AAA domain AAA_29 PF13555.6 CCF43568.1 - 0.038 13.7 0.0 0.083 12.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain NB-ARC PF00931.22 CCF43568.1 - 0.043 13.0 1.9 0.24 10.5 0.0 2.8 3 0 0 3 3 3 0 NB-ARC domain Talin_middle PF09141.10 CCF43568.1 - 0.059 13.4 1.3 0.32 11.0 0.1 2.8 3 0 0 3 3 3 0 Talin, middle domain KAP_NTPase PF07693.14 CCF43568.1 - 0.13 11.5 0.0 0.13 11.5 0.0 2.6 4 1 0 4 4 4 0 KAP family P-loop domain Prefoldin PF02996.17 CCF43568.1 - 0.59 10.1 11.6 4.9 7.1 3.1 3.5 3 0 0 3 3 3 0 Prefoldin subunit DUF87 PF01935.17 CCF43568.1 - 0.68 10.0 10.2 1.5 8.9 0.0 3.8 3 2 1 4 4 4 0 Helicase HerA, central domain Golgin_A5 PF09787.9 CCF43568.1 - 1 8.7 14.8 0.31 10.5 7.3 2.8 2 0 0 2 2 2 0 Golgin subfamily A member 5 DUF16 PF01519.16 CCF43568.1 - 1.5 9.4 9.3 5 7.7 1.8 3.7 3 0 0 3 3 2 0 Protein of unknown function DUF16 ParB PF08775.10 CCF43568.1 - 3.3 8.2 10.2 1 9.8 0.5 3.8 3 0 0 3 3 3 0 ParB family FliT PF05400.13 CCF43568.1 - 5.6 7.9 7.4 5.9 7.8 2.3 3.3 2 0 0 2 2 2 0 Flagellar protein FliT Sec34 PF04136.15 CCF43568.1 - 8.4 6.3 8.7 4.8 7.0 2.5 3.2 3 0 0 3 3 3 0 Sec34-like family NUDIX_2 PF13869.6 CCF43569.1 - 5.3e-81 270.7 0.0 6.3e-81 270.5 0.0 1.0 1 0 0 1 1 1 1 Nucleotide hydrolase UPF0047 PF01894.17 CCF43570.1 - 8.7e-38 129.0 0.0 9.9e-38 128.8 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family UPF0047 2OG-Fe_Oxy_2 PF10014.9 CCF43571.1 - 0.83 9.4 6.9 0.54 10.0 0.5 2.6 2 1 1 3 3 3 0 2OG-Fe dioxygenase Abhydrolase_2 PF02230.16 CCF43572.1 - 2.5e-05 24.2 0.0 0.0001 22.2 0.0 1.7 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase Thioesterase PF00975.20 CCF43572.1 - 0.21 11.7 0.0 0.28 11.3 0.0 1.3 1 0 0 1 1 1 0 Thioesterase domain HEAT PF02985.22 CCF43573.1 - 7.1e-17 60.1 0.0 0.07 13.4 0.0 5.2 5 0 0 5 5 5 5 HEAT repeat HEAT_2 PF13646.6 CCF43573.1 - 1.2e-10 41.6 0.0 0.0013 19.1 0.0 3.2 3 0 0 3 3 3 3 HEAT repeats HEAT_EZ PF13513.6 CCF43573.1 - 0.018 15.5 0.0 3.1 8.4 0.0 3.0 2 0 0 2 2 2 0 HEAT-like repeat Vac14_Fab1_bd PF12755.7 CCF43573.1 - 0.044 14.4 0.0 6.2 7.5 0.0 3.0 2 1 0 3 3 3 0 Vacuolar 14 Fab1-binding region Methyltransf_31 PF13847.6 CCF43574.1 - 1.7e-14 53.9 0.0 5.1e-09 36.1 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_23 PF13489.6 CCF43574.1 - 5e-08 32.9 0.2 1.8e-07 31.1 0.2 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF43574.1 - 1.6e-07 31.9 0.0 3e-06 27.9 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF43574.1 - 4.4e-07 30.5 0.0 2.6e-06 28.1 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF43574.1 - 2.4e-06 28.1 0.2 6.8e-05 23.4 0.0 2.5 2 1 0 2 2 2 1 Methyltransferase domain AdoMet_MTase PF07757.13 CCF43574.1 - 6.5e-05 23.2 0.0 0.00016 22.0 0.0 1.7 2 0 0 2 2 2 1 Predicted AdoMet-dependent methyltransferase Methyltransf_32 PF13679.6 CCF43574.1 - 8.8e-05 22.5 0.0 0.00012 22.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CCF43574.1 - 0.0075 15.8 0.0 0.012 15.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain MetW PF07021.12 CCF43574.1 - 0.013 15.1 0.0 0.023 14.3 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW PrmA PF06325.13 CCF43574.1 - 0.045 13.1 0.0 0.067 12.6 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) DUF4632 PF15451.6 CCF43574.1 - 0.16 12.1 4.3 0.15 12.1 3.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4632) Adeno_terminal PF02459.15 CCF43574.1 - 1.5 7.1 2.6 2.1 6.7 2.6 1.1 1 0 0 1 1 1 0 Adenoviral DNA terminal protein p450 PF00067.22 CCF43576.1 - 5.9e-61 206.6 0.0 6.7e-61 206.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Zw10 PF06248.13 CCF43579.1 - 0.0066 15.1 0.7 0.0074 14.9 0.7 1.0 1 0 0 1 1 1 1 Centromere/kinetochore Zw10 DUF515 PF04415.12 CCF43579.1 - 0.04 12.3 1.2 0.04 12.3 1.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF515) HEAT PF02985.22 CCF43582.1 - 0.037 14.3 1.1 4.1 7.9 0.1 4.0 3 0 0 3 3 3 0 HEAT repeat HEAT_2 PF13646.6 CCF43582.1 - 0.19 12.1 0.7 28 5.2 0.0 2.8 3 0 0 3 3 3 0 HEAT repeats Condensation PF00668.20 CCF43584.1 - 1.8e-10 40.1 0.1 2e-10 40.0 0.1 1.0 1 0 0 1 1 1 1 Condensation domain Metallophos PF00149.28 CCF43585.1 - 2.6e-09 37.9 0.0 3.9e-09 37.3 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CCF43585.1 - 9.6e-06 25.9 0.0 0.00019 21.7 0.0 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain PITH PF06201.13 CCF43588.1 - 2.1e-35 122.2 0.0 3.1e-35 121.7 0.0 1.2 1 0 0 1 1 1 1 PITH domain Thioredoxin PF00085.20 CCF43588.1 - 7.3e-28 96.6 0.0 1.2e-27 95.9 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.13 CCF43588.1 - 5.8e-07 29.2 0.0 8.8e-07 28.6 0.0 1.2 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 CCF43588.1 - 3.3e-06 27.5 0.2 4e-05 24.0 0.2 2.3 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 CCF43588.1 - 7.6e-06 26.2 0.0 0.0015 18.8 0.0 2.4 1 1 1 2 2 2 2 Thioredoxin-like AhpC-TSA PF00578.21 CCF43588.1 - 0.0033 17.4 0.0 0.01 15.8 0.0 1.8 2 0 0 2 2 2 1 AhpC/TSA family Thioredoxin_9 PF14595.6 CCF43588.1 - 0.015 15.0 0.0 0.024 14.4 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin Thioredoxin_7 PF13899.6 CCF43588.1 - 0.017 15.3 0.0 0.044 14.0 0.0 1.6 2 0 0 2 2 2 0 Thioredoxin-like HyaE PF07449.11 CCF43588.1 - 0.069 13.1 0.0 0.24 11.4 0.0 1.8 2 0 0 2 2 2 0 Hydrogenase-1 expression protein HyaE DUF1207 PF06727.11 CCF43588.1 - 0.12 11.3 0.0 0.19 10.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1207) DNA_pol_phi PF04931.13 CCF43590.1 - 0.056 11.6 8.4 0.07 11.2 8.4 1.1 1 0 0 1 1 1 0 DNA polymerase phi Pox_Ag35 PF03286.14 CCF43590.1 - 1.6 8.5 6.7 2.4 7.9 6.7 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein CENP-B_dimeris PF09026.10 CCF43590.1 - 1.7 9.1 16.8 2.6 8.5 16.8 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain FAM176 PF14851.6 CCF43590.1 - 1.9 8.2 5.5 3.2 7.4 5.5 1.3 1 0 0 1 1 1 0 FAM176 family SDA1 PF05285.12 CCF43590.1 - 2 7.7 7.0 2.6 7.4 7.0 1.1 1 0 0 1 1 1 0 SDA1 GCIP PF13324.6 CCF43590.1 - 5.5 6.5 8.5 6.7 6.2 8.5 1.1 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting GMC_oxred_N PF00732.19 CCF43591.1 - 2e-44 152.1 0.0 2.7e-44 151.7 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCF43591.1 - 4.2e-32 111.6 0.1 6.7e-32 111.0 0.1 1.3 1 0 0 1 1 1 1 GMC oxidoreductase LSDAT_prok PF18171.1 CCF43591.1 - 0.054 12.7 0.9 0.099 11.9 0.9 1.4 1 0 0 1 1 1 0 SLOG in TRPM, prokaryote ADH_zinc_N PF00107.26 CCF43594.1 - 5.2e-32 110.6 1.9 7.6e-32 110.0 1.9 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCF43594.1 - 3.4e-13 50.8 0.1 6e-13 50.0 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCF43594.1 - 1.9e-06 27.7 0.0 5.3e-06 26.3 0.0 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain TrkA_N PF02254.18 CCF43594.1 - 0.0034 17.6 0.3 0.007 16.6 0.3 1.4 1 0 0 1 1 1 1 TrkA-N domain adh_short PF00106.25 CCF43594.1 - 0.034 13.6 0.5 0.049 13.1 0.5 1.3 1 0 0 1 1 1 0 short chain dehydrogenase AlaDh_PNT_C PF01262.21 CCF43594.1 - 0.19 11.0 5.8 0.24 10.7 5.4 1.4 1 1 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain CN_hydrolase PF00795.22 CCF43595.1 - 1.2e-17 64.1 0.0 1.8e-17 63.5 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase ThrE PF06738.12 CCF43597.1 - 2.4e-23 82.8 0.0 3.2e-23 82.3 0.0 1.2 1 0 0 1 1 1 1 Putative threonine/serine exporter Zn_clus PF00172.18 CCF43599.1 - 6.6e-06 26.1 7.9 1.1e-05 25.4 7.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain HTH_Tnp_Tc5 PF03221.16 CCF43600.1 - 0.08 13.0 0.0 0.65 10.1 0.0 2.3 2 0 0 2 2 2 0 Tc5 transposase DNA-binding domain NB-ARC PF00931.22 CCF43601.1 - 6.7e-06 25.5 0.0 1.3e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain PNP_UDP_1 PF01048.20 CCF43601.1 - 0.00026 20.4 0.1 0.0013 18.1 0.1 2.0 1 1 0 1 1 1 1 Phosphorylase superfamily RNase_H_2 PF13482.6 CCF43601.1 - 0.086 12.8 0.0 3.1 7.7 0.0 2.5 2 0 0 2 2 2 0 RNase_H superfamily VEFS-Box PF09733.9 CCF43601.1 - 0.95 9.3 4.0 1.8 8.4 4.0 1.4 1 0 0 1 1 1 0 VEFS-Box of polycomb protein CENP-B_dimeris PF09026.10 CCF43601.1 - 1.4 9.3 11.1 4.1 7.8 11.1 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DNMT1-RFD PF12047.8 CCF43602.1 - 0.067 13.2 0.2 0.21 11.6 0.0 1.9 2 1 0 2 2 2 0 Cytosine specific DNA methyltransferase replication foci domain Poxvirus_B22R PF04395.12 CCF43603.1 - 0.16 11.5 5.1 0.064 12.8 2.0 1.8 2 0 0 2 2 2 0 Poxvirus B22R protein Ribosomal_L11 PF00298.19 CCF43605.1 - 0.05 14.1 2.0 0.17 12.4 2.0 1.9 1 0 0 1 1 1 0 Ribosomal protein L11, RNA binding domain DUF1192 PF06698.11 CCF43605.1 - 0.61 10.2 24.7 11 6.2 0.8 7.2 6 1 0 6 6 6 0 Protein of unknown function (DUF1192) DEAD PF00270.29 CCF43606.1 - 1.5e-43 148.6 0.0 5.7e-43 146.7 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF43606.1 - 8.2e-27 93.8 0.1 1.8e-26 92.7 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Mitofilin PF09731.9 CCF43606.1 - 0.00072 18.5 15.0 0.00072 18.5 15.0 2.1 3 0 0 3 3 3 1 Mitochondrial inner membrane protein CCDC117 PF15810.5 CCF43606.1 - 0.048 14.0 0.2 0.048 14.0 0.2 3.6 3 1 1 4 4 4 0 Coiled-coil domain-containing protein 117 WSD PF15613.6 CCF43606.1 - 0.059 13.9 0.1 0.059 13.9 0.1 2.9 2 1 0 2 2 2 0 Williams-Beuren syndrome DDT (WSD), D-TOX E motif Zip PF02535.22 CCF43606.1 - 0.12 11.5 0.4 0.23 10.6 0.4 1.5 1 0 0 1 1 1 0 ZIP Zinc transporter BBE PF08031.12 CCF43607.1 - 2.5e-11 43.5 0.0 3.2e-11 43.1 0.0 1.2 1 0 0 1 1 1 1 Berberine and berberine like M20_dimer PF07687.14 CCF43608.1 - 4.1e-19 68.5 0.1 7.2e-19 67.7 0.1 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M20 PF01546.28 CCF43608.1 - 2.1e-18 66.8 0.5 4.6e-17 62.4 0.5 2.1 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M28 PF04389.17 CCF43608.1 - 0.0017 18.1 0.0 0.0025 17.6 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 IF-2B PF01008.17 CCF43609.1 - 1.8e-63 214.4 0.5 2.3e-63 214.1 0.5 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family DNA_gyraseB PF00204.25 CCF43611.1 - 0.029 13.9 0.0 0.033 13.7 0.0 1.1 1 0 0 1 1 1 0 DNA gyrase B Phage_TAC_6 PF09550.10 CCF43611.1 - 0.12 12.9 0.0 0.24 11.9 0.0 1.5 1 1 1 2 2 2 0 Phage tail assembly chaperone protein, TAC GH43_C2 PF17851.1 CCF43612.1 - 0.00016 21.5 0.0 0.00025 20.8 0.0 1.3 1 1 0 1 1 1 1 Beta xylosidase C-terminal Concanavalin A-like domain p450 PF00067.22 CCF43613.1 - 5.8e-43 147.3 0.0 1.7e-27 96.3 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 Ank_2 PF12796.7 CCF43614.1 - 2.5e-16 60.0 0.0 1.9e-06 28.3 0.0 4.8 3 1 1 4 4 4 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CCF43614.1 - 1e-11 43.9 2.8 0.00096 19.4 0.0 8.3 10 1 0 10 10 10 2 Ankyrin repeat Ank PF00023.30 CCF43614.1 - 3.6e-11 43.0 0.3 0.00014 22.2 0.0 6.1 6 0 0 6 6 6 1 Ankyrin repeat Ank_5 PF13857.6 CCF43614.1 - 8.7e-09 35.5 0.0 6.3e-07 29.5 0.0 3.6 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 CCF43614.1 - 1.3e-07 32.0 0.8 0.17 12.5 0.0 6.4 5 2 2 7 7 7 3 Ankyrin repeats (many copies) GMC_oxred_C PF05199.13 CCF43616.1 - 4.9e-06 27.1 0.0 1.9e-05 25.2 0.0 2.0 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_N PF00732.19 CCF43616.1 - 1.5e-05 24.6 0.0 0.0016 17.9 0.0 2.5 2 0 0 2 2 2 1 GMC oxidoreductase FAD_binding_2 PF00890.24 CCF43616.1 - 6e-05 22.3 0.0 0.00013 21.2 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CCF43616.1 - 0.00054 19.3 0.3 0.0012 18.2 0.3 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 CCF43616.1 - 0.0011 18.4 0.2 0.0017 17.8 0.2 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CCF43616.1 - 0.0065 16.7 0.1 0.022 15.0 0.1 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CCF43616.1 - 0.017 14.7 0.0 0.17 11.4 0.0 2.4 2 0 0 2 2 2 0 FAD dependent oxidoreductase HI0933_like PF03486.14 CCF43616.1 - 0.032 12.9 0.1 0.051 12.3 0.1 1.3 1 0 0 1 1 1 0 HI0933-like protein GIDA PF01134.22 CCF43616.1 - 0.048 12.7 0.6 0.075 12.1 0.6 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A Pyr_redox PF00070.27 CCF43616.1 - 0.081 13.5 0.0 0.27 11.8 0.0 1.9 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HATPase_c PF02518.26 CCF43618.1 - 4.4e-26 91.6 0.3 8.4e-26 90.7 0.3 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CCF43618.1 - 1.3e-22 80.1 0.3 8.3e-22 77.5 0.1 2.4 2 0 0 2 2 2 1 Response regulator receiver domain PAS_3 PF08447.12 CCF43618.1 - 1.4e-22 79.8 0.8 2.2e-12 47.1 0.3 3.8 3 0 0 3 3 3 3 PAS fold HisKA PF00512.25 CCF43618.1 - 2.2e-20 72.5 0.3 1.2e-19 70.0 0.1 2.6 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain PAS PF00989.25 CCF43618.1 - 1.6e-08 34.6 0.0 0.0074 16.3 0.0 2.7 2 0 0 2 2 2 2 PAS fold PAS_4 PF08448.10 CCF43618.1 - 1.6e-08 34.7 0.2 4.4e-06 26.9 0.1 3.2 3 0 0 3 3 3 1 PAS fold PAS_9 PF13426.7 CCF43618.1 - 1.8e-08 34.6 0.0 0.0061 16.8 0.0 3.8 3 0 0 3 3 3 2 PAS domain PAS_8 PF13188.7 CCF43618.1 - 0.00091 19.2 0.0 0.15 12.1 0.0 2.6 2 0 0 2 2 2 1 PAS domain Cpn60_TCP1 PF00118.24 CCF43620.1 - 9.4e-170 565.4 0.1 1.1e-169 565.2 0.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family BRK PF07533.16 CCF43620.1 - 0.019 14.6 0.0 0.037 13.7 0.0 1.5 1 0 0 1 1 1 0 BRK domain DAHP_synth_2 PF01474.16 CCF43621.1 - 1.9e-54 184.8 0.0 2.3e-54 184.6 0.0 1.0 1 0 0 1 1 1 1 Class-II DAHP synthetase family Lectin_leg-like PF03388.13 CCF43623.1 - 7.5e-15 54.9 0.0 1.4e-14 54.0 0.0 1.3 1 0 0 1 1 1 1 Legume-like lectin family Tmemb_cc2 PF10267.9 CCF43623.1 - 0.00052 19.3 9.5 0.00072 18.8 9.5 1.1 1 0 0 1 1 1 1 Predicted transmembrane and coiled-coil 2 protein DUF5523 PF17661.1 CCF43623.1 - 0.0042 16.8 0.3 0.0067 16.1 0.3 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5523) Baculo_PEP_C PF04513.12 CCF43623.1 - 0.0089 16.1 0.8 0.018 15.1 0.8 1.4 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus PI_PP_C PF18365.1 CCF43623.1 - 0.024 14.6 0.1 0.054 13.5 0.1 1.5 1 0 0 1 1 1 0 Phosphoinositide phosphatase C-terminal domain Stevor PF17410.2 CCF43623.1 - 0.049 13.2 0.0 0.091 12.3 0.0 1.4 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame DUF2722 PF10846.8 CCF43623.1 - 0.054 12.4 13.4 0.076 11.9 13.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) TFIIA PF03153.13 CCF43623.1 - 0.063 13.3 14.9 0.083 12.9 14.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit MCU PF04678.13 CCF43623.1 - 0.1 12.7 1.9 0.69 10.0 0.1 2.2 2 0 0 2 2 2 0 Mitochondrial calcium uniporter FPP PF05911.11 CCF43623.1 - 0.13 10.4 8.4 0.18 10.0 8.4 1.1 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil DUF948 PF06103.11 CCF43623.1 - 0.15 12.3 0.3 1 9.7 0.3 2.1 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) PDGLE PF13190.6 CCF43623.1 - 0.21 11.5 0.9 1.6 8.7 0.0 2.3 2 0 0 2 2 2 0 PDGLE domain DUF1204 PF06721.11 CCF43623.1 - 0.21 11.0 2.3 0.34 10.3 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1204) DUF4175 PF13779.6 CCF43623.1 - 0.36 8.7 16.0 0.47 8.3 16.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DUF812 PF05667.11 CCF43623.1 - 0.43 9.4 12.7 0.56 9.0 12.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF812) DUF2730 PF10805.8 CCF43623.1 - 0.48 10.6 2.0 1.6 8.9 1.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) FUSC PF04632.12 CCF43623.1 - 0.81 8.1 3.7 1.3 7.4 3.6 1.3 1 1 0 1 1 1 0 Fusaric acid resistance protein family Roughex PF06020.11 CCF43623.1 - 1.2 8.2 5.4 1.6 7.7 5.4 1.1 1 0 0 1 1 1 0 Drosophila roughex protein FAM76 PF16046.5 CCF43623.1 - 1.4 8.2 11.2 2.1 7.6 11.2 1.2 1 0 0 1 1 1 0 FAM76 protein DUF4407 PF14362.6 CCF43623.1 - 1.5 8.1 10.9 2.7 7.3 10.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Med3 PF11593.8 CCF43623.1 - 1.6 7.8 18.6 0.87 8.7 15.5 1.8 1 1 1 2 2 2 0 Mediator complex subunit 3 fungal CPSF100_C PF13299.6 CCF43623.1 - 2.8 8.1 6.2 3.5 7.8 5.7 1.5 1 1 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal MscS_TM PF12794.7 CCF43623.1 - 4.1 6.2 3.9 6.2 5.6 3.9 1.3 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 ABC_tran_CTD PF16326.5 CCF43623.1 - 6.3 7.1 9.6 3.3 8.0 0.4 3.3 2 1 2 4 4 4 0 ABC transporter C-terminal domain Helicase_C PF00271.31 CCF43625.1 - 3.6e-30 104.6 0.0 1.7e-29 102.4 0.0 2.0 1 1 1 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 CCF43625.1 - 2.4e-17 63.3 0.0 9.6e-17 61.3 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase SAD_SRA PF02182.17 CCF43626.1 - 1.5e-06 28.0 0.3 3.1e-06 27.0 0.1 1.6 2 0 0 2 2 2 1 SAD/SRA domain PMT PF02366.18 CCF43627.1 - 1.3e-80 270.5 15.1 1.3e-80 270.5 15.1 2.1 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 CCF43627.1 - 3.9e-69 232.2 11.6 3.9e-69 232.2 11.6 2.3 2 0 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 CCF43627.1 - 3.9e-46 157.2 0.0 9.8e-46 155.9 0.0 1.7 1 1 0 1 1 1 1 MIR domain Polysacc_deac_1 PF01522.21 CCF43628.1 - 1.2e-27 96.2 0.0 3.2e-27 94.9 0.0 1.6 2 0 0 2 2 2 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.15 CCF43628.1 - 0.001 18.3 0.0 0.0026 17.0 0.0 1.6 1 1 1 2 2 2 1 Glycosyl hydrolase family 57 ERG4_ERG24 PF01222.17 CCF43629.1 - 8e-140 466.4 17.5 9.3e-140 466.2 17.5 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family Glyco_hydro_18 PF00704.28 CCF43630.1 - 9e-80 268.7 0.3 1e-79 268.5 0.3 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Peptidase_M7 PF02031.16 CCF43630.1 - 0.031 14.4 0.3 0.068 13.3 0.3 1.5 1 0 0 1 1 1 0 Streptomyces extracellular neutral proteinase (M7) family Glyco_hydro_2_C PF02836.17 CCF43631.1 - 8.4e-104 346.9 0.0 1.1e-103 346.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2_N PF02837.18 CCF43631.1 - 2.7e-47 160.8 0.6 6.7e-47 159.5 0.3 1.8 2 0 0 2 2 2 1 Glycosyl hydrolases family 2, sugar binding domain DUF4981 PF16353.5 CCF43631.1 - 1.1e-21 77.1 1.0 6.3e-20 71.4 0.1 2.8 2 1 0 2 2 2 1 Domain of unknown function(DUF4981) Glyco_hydro_2 PF00703.21 CCF43631.1 - 5.4e-16 59.2 0.2 1.3e-15 58.0 0.2 1.7 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 Bgal_small_N PF02929.17 CCF43631.1 - 4.7e-08 33.0 0.0 9.6e-08 31.9 0.0 1.6 1 0 0 1 1 1 1 Beta galactosidase small chain tRNA-synt_2b PF00587.25 CCF43633.1 - 4.1e-19 69.2 0.0 8.2e-19 68.3 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 CCF43633.1 - 1.1e-11 44.9 6.8 2.6e-11 43.7 6.8 1.7 1 1 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain EspB_PE PF18625.1 CCF43633.1 - 0.24 11.9 2.9 0.74 10.3 2.9 1.8 1 0 0 1 1 1 0 ESX-1 secreted protein B PE domain FapA PF03961.13 CCF43633.1 - 0.3 9.6 1.5 0.42 9.2 1.5 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A RRM_1 PF00076.22 CCF43635.1 - 9.7e-46 153.5 0.0 1.4e-16 60.0 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 CCF43635.1 - 1.8e-05 24.6 0.1 0.0023 17.9 0.1 3.1 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 CCF43635.1 - 0.00012 21.8 0.0 0.053 13.4 0.0 3.1 3 0 0 3 3 3 1 Occluded RNA-recognition motif RRM_7 PF16367.5 CCF43635.1 - 0.00012 22.1 0.1 0.055 13.6 0.0 2.9 3 0 0 3 3 3 2 RNA recognition motif RRM_3 PF08777.11 CCF43635.1 - 0.00019 21.4 0.0 0.0018 18.3 0.0 2.4 3 0 0 3 3 3 1 RNA binding motif RRM_5 PF13893.6 CCF43635.1 - 0.033 13.8 0.0 0.12 12.0 0.0 1.8 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Cyt-b5 PF00173.28 CCF43636.1 - 4.5e-15 55.6 0.1 5.2e-15 55.4 0.1 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Acetyltransf_1 PF00583.25 CCF43637.1 - 1e-08 35.4 0.0 1.4e-08 35.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CCF43637.1 - 7.7e-05 22.6 0.0 0.00012 22.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CCF43637.1 - 0.0001 22.7 0.0 0.00016 22.0 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CCF43637.1 - 0.02 14.9 0.0 0.029 14.3 0.0 1.4 1 0 0 1 1 1 0 FR47-like protein Acetyltransf_9 PF13527.7 CCF43637.1 - 0.028 14.5 0.0 0.16 12.0 0.0 2.0 1 1 1 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 CCF43637.1 - 0.059 13.5 0.0 0.1 12.8 0.0 1.3 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase PHD PF00628.29 CCF43638.1 - 0.068 13.1 4.9 1.1 9.1 1.0 2.3 2 0 0 2 2 2 0 PHD-finger VATC PF18716.1 CCF43638.1 - 0.22 11.4 5.3 2.9 7.8 1.1 2.4 2 1 0 2 2 2 0 Vms1-associating treble clef domain zinc_ribbon_2 PF13240.6 CCF43638.1 - 4.3 7.2 10.0 3.4 7.5 1.1 2.7 2 1 0 2 2 2 0 zinc-ribbon domain Homeodomain PF00046.29 CCF43639.1 - 3.5e-15 55.6 0.7 7.6e-15 54.5 0.7 1.6 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 CCF43639.1 - 0.018 14.9 0.0 0.054 13.4 0.0 1.9 1 0 0 1 1 1 0 Homeobox KN domain Porin_8 PF16966.5 CCF43639.1 - 0.07 12.1 0.1 0.13 11.3 0.1 1.3 1 0 0 1 1 1 0 Porin-like glycoporin RafY TFIIA PF03153.13 CCF43639.1 - 0.29 11.1 21.1 0.36 10.8 21.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SLX9 PF15341.6 CCF43641.1 - 1.6e-41 141.8 2.3 1.9e-41 141.5 2.3 1.1 1 0 0 1 1 1 1 Ribosome biogenesis protein SLX9 KGG PF10685.9 CCF43642.1 - 1.3e-10 41.1 0.2 1.3e-10 41.1 0.2 2.0 2 0 0 2 2 2 1 Stress-induced bacterial acidophilic repeat motif RNA_pol_A_bac PF01000.26 CCF43643.1 - 6.9e-28 97.3 0.0 1.3e-27 96.3 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 CCF43643.1 - 8.4e-20 70.0 0.0 1.6e-19 69.1 0.0 1.5 1 1 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Phage_1_1 PF08200.11 CCF43643.1 - 0.17 12.3 0.1 0.35 11.3 0.1 1.4 1 0 0 1 1 1 0 Bacteriophage 1.1 Protein ThiF PF00899.21 CCF43644.1 - 2.4e-60 203.9 0.1 3.6e-60 203.3 0.1 1.3 1 0 0 1 1 1 1 ThiF family E2_bind PF08825.10 CCF43644.1 - 5.6e-28 96.9 1.0 9.9e-28 96.1 1.0 1.3 1 0 0 1 1 1 1 E2 binding domain UAE_UbL PF14732.6 CCF43644.1 - 0.0057 17.2 0.1 0.077 13.6 0.0 2.4 2 0 0 2 2 2 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain UBA_e1_thiolCys PF10585.9 CCF43644.1 - 0.23 11.4 2.8 6.6 6.6 0.0 2.3 1 1 1 2 2 2 0 Ubiquitin-activating enzyme active site Telomere_reg-2 PF10193.9 CCF43645.1 - 1e-36 125.7 0.0 6.9e-36 123.0 0.0 2.5 2 0 0 2 2 2 1 Telomere length regulation protein DEAD_assoc PF08494.11 CCF43645.1 - 0.015 15.1 0.0 0.035 13.9 0.0 1.7 1 0 0 1 1 1 0 DEAD/H associated Nuf2 PF03800.14 CCF43647.1 - 8e-42 142.7 0.0 1.3e-41 142.0 0.0 1.3 1 0 0 1 1 1 1 Nuf2 family Exonuc_VII_L PF02601.15 CCF43647.1 - 0.018 14.6 0.1 0.021 14.4 0.1 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit APG6_N PF17675.1 CCF43647.1 - 0.033 14.7 7.5 0.06 13.9 7.5 1.5 1 0 0 1 1 1 0 Apg6 coiled-coil region MscS_porin PF12795.7 CCF43647.1 - 0.042 13.4 8.7 0.063 12.8 8.7 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain Vg_Tdu PF07545.14 CCF43647.1 - 0.042 13.6 0.1 0.08 12.7 0.1 1.4 1 0 0 1 1 1 0 Vestigial/Tondu family DUF3450 PF11932.8 CCF43647.1 - 0.08 12.2 8.2 0.13 11.5 8.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DivIC PF04977.15 CCF43647.1 - 0.16 11.8 9.1 0.18 11.6 6.0 2.1 1 1 1 2 2 2 0 Septum formation initiator Prefoldin_2 PF01920.20 CCF43647.1 - 0.24 11.4 9.2 0.31 11.0 0.7 2.8 2 1 1 3 3 3 0 Prefoldin subunit Uso1_p115_C PF04871.13 CCF43647.1 - 0.29 11.5 11.8 0.47 10.8 11.8 1.3 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region UPF0242 PF06785.11 CCF43647.1 - 0.52 10.4 7.5 0.75 9.9 7.5 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus YabA PF06156.13 CCF43647.1 - 0.54 10.9 5.1 1.1 10.0 5.1 1.6 1 0 0 1 1 1 0 Initiation control protein YabA CpxA_peri PF16527.5 CCF43647.1 - 0.66 10.4 5.8 1.6 9.1 4.1 2.3 2 1 1 3 3 3 0 Two-component sensor protein CpxA, periplasmic domain V_ATPase_I PF01496.19 CCF43647.1 - 1.1 7.2 4.6 1.3 6.8 4.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Nup54 PF13874.6 CCF43647.1 - 2.9 8.0 11.9 8.9 6.4 11.9 1.7 1 1 0 1 1 1 0 Nucleoporin complex subunit 54 Rx_N PF18052.1 CCF43647.1 - 5.4 7.4 8.1 9.4 6.6 3.6 2.2 1 1 1 2 2 2 0 Rx N-terminal domain DUF5453 PF17534.2 CCF43649.1 - 0.088 12.8 4.1 0.19 11.7 4.1 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5453) ANAPC_CDC26 PF10471.9 CCF43651.1 - 1.3e-08 35.5 28.7 1.3e-08 35.5 28.7 3.3 1 1 1 2 2 2 1 Anaphase-promoting complex APC subunit CDC26 TFIIA PF03153.13 CCF43651.1 - 0.57 10.1 36.6 0.69 9.9 36.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Pex14_N PF04695.13 CCF43651.1 - 1.6 9.4 21.9 2.9 8.5 21.9 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Presenilin PF01080.17 CCF43651.1 - 6.1 5.5 13.4 6.6 5.4 13.4 1.1 1 0 0 1 1 1 0 Presenilin MFS_1 PF07690.16 CCF43655.1 - 1.2e-23 83.7 18.3 1.2e-23 83.7 18.3 1.8 2 0 0 2 2 2 1 Major Facilitator Superfamily zf-HIT PF04438.16 CCF43657.1 - 1.5e-07 31.1 10.8 2.2e-07 30.6 10.8 1.2 1 0 0 1 1 1 1 HIT zinc finger zf-MYND PF01753.18 CCF43657.1 - 0.0049 16.9 5.6 0.0081 16.2 5.6 1.3 1 0 0 1 1 1 1 MYND finger zf-B_box PF00643.24 CCF43657.1 - 0.025 14.8 5.5 0.035 14.2 5.5 1.2 1 0 0 1 1 1 0 B-box zinc finger NUC173 PF08161.12 CCF43659.1 - 4.4e-81 271.4 2.3 1.1e-78 263.6 0.1 3.3 4 0 0 4 4 4 2 NUC173 domain HEAT_2 PF13646.6 CCF43659.1 - 0.052 13.9 2.0 13 6.3 0.1 4.4 4 0 0 4 4 4 0 HEAT repeats HEAT PF02985.22 CCF43659.1 - 0.077 13.3 1.9 4.4 7.8 0.0 4.0 4 0 0 4 4 4 0 HEAT repeat HHA PF05321.11 CCF43659.1 - 0.22 11.8 1.6 4.3 7.7 0.0 3.5 4 0 0 4 4 4 0 Haemolysin expression modulating protein TFCD_C PF12612.8 CCF43659.1 - 0.73 9.6 3.5 22 4.8 0.0 4.7 5 2 2 7 7 7 0 Tubulin folding cofactor D C terminal V-SNARE_C PF12352.8 CCF43660.1 - 2.3e-20 72.6 2.2 2.3e-20 72.6 2.2 2.1 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus V-SNARE PF05008.15 CCF43660.1 - 8.4e-20 70.9 2.0 8.4e-20 70.9 2.0 1.9 2 0 0 2 2 2 1 Vesicle transport v-SNARE protein N-terminus Sec20 PF03908.13 CCF43660.1 - 0.0055 16.6 1.0 0.012 15.5 0.2 2.1 2 2 0 2 2 2 1 Sec20 FAM76 PF16046.5 CCF43660.1 - 0.0094 15.3 0.1 0.017 14.5 0.1 1.3 1 0 0 1 1 1 1 FAM76 protein Fusion_gly PF00523.18 CCF43660.1 - 0.028 12.7 0.9 0.059 11.6 0.2 1.7 2 0 0 2 2 2 0 Fusion glycoprotein F0 Spectrin PF00435.21 CCF43660.1 - 0.14 12.6 4.2 0.26 11.8 0.5 2.6 1 1 2 3 3 3 0 Spectrin repeat SNARE PF05739.19 CCF43660.1 - 0.32 11.0 2.5 0.32 11.0 0.6 2.0 2 0 0 2 2 2 0 SNARE domain Exonuc_VII_L PF02601.15 CCF43660.1 - 0.44 10.1 7.9 1.2 8.6 7.9 1.6 1 1 0 1 1 1 0 Exonuclease VII, large subunit Use1 PF09753.9 CCF43660.1 - 0.5 10.1 5.2 1.5 8.5 5.2 1.9 1 1 0 1 1 1 0 Membrane fusion protein Use1 YqjK PF13997.6 CCF43660.1 - 1.2 9.4 5.2 4.9 7.5 0.1 2.8 3 0 0 3 3 3 0 YqjK-like protein NAD_binding_8 PF13450.6 CCF43661.1 - 7e-09 35.8 0.1 8.6e-09 35.5 0.1 1.1 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CCF43661.1 - 2e-05 24.0 0.0 2.1e-05 23.9 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 CCF43661.1 - 6.7e-05 22.4 0.0 7.3e-05 22.2 0.0 1.0 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase FAD_oxidored PF12831.7 CCF43661.1 - 0.00085 18.8 0.0 0.00085 18.8 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO PF01266.24 CCF43661.1 - 0.0028 17.3 0.1 0.003 17.2 0.1 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.22 CCF43661.1 - 0.011 14.9 0.1 0.011 14.8 0.1 1.1 1 0 0 1 1 1 0 Glucose inhibited division protein A FAD_binding_2 PF00890.24 CCF43661.1 - 0.029 13.5 0.0 0.034 13.2 0.0 1.1 1 0 0 1 1 1 0 FAD binding domain DUF1297 PF06973.12 CCF43661.1 - 0.061 12.9 0.0 0.074 12.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1297) HI0933_like PF03486.14 CCF43661.1 - 0.081 11.6 0.0 0.099 11.3 0.0 1.1 1 0 0 1 1 1 0 HI0933-like protein Glu_dehyd_C PF16912.5 CCF43661.1 - 0.092 12.2 0.0 0.093 12.2 0.0 1.1 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 CCF43661.1 - 0.1 11.9 0.0 0.1 11.9 0.0 1.1 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Rossmann-like PF10727.9 CCF43661.1 - 0.11 12.4 0.0 0.16 11.8 0.0 1.3 1 1 0 1 1 1 0 Rossmann-like domain Thi4 PF01946.17 CCF43661.1 - 0.12 11.6 0.0 0.14 11.4 0.0 1.1 1 0 0 1 1 1 0 Thi4 family NAD_Gly3P_dh_N PF01210.23 CCF43661.1 - 0.13 12.2 0.2 0.14 12.1 0.2 1.1 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Histone_H2A_C PF16211.5 CCF43662.1 - 2.4e-21 75.2 3.1 4.2e-21 74.4 3.1 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 CCF43662.1 - 7e-17 62.0 0.0 9.1e-17 61.7 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CCF43662.1 - 9.7e-06 25.8 0.0 1.3e-05 25.3 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Complex1_LYR PF05347.15 CCF43663.1 - 4.6e-10 39.4 2.1 6.2e-10 39.0 2.1 1.2 1 0 0 1 1 1 1 Complex 1 protein (LYR family) DIOX_N PF14226.6 CCF43664.1 - 5.8e-24 85.1 0.0 9e-24 84.5 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 CCF43664.1 - 3e-20 72.6 0.0 4.7e-20 72.0 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF3112 PF11309.8 CCF43666.1 - 0.14 11.6 1.3 0.4 10.1 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3112) S36_mt PF10937.8 CCF43666.1 - 0.15 13.6 0.0 0.33 12.6 0.0 1.5 1 1 1 2 2 2 0 Ribosomal protein S36, mitochondrial Methyltransf_23 PF13489.6 CCF43668.1 - 1.8e-06 27.9 0.0 2.3e-06 27.5 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF43668.1 - 8.4e-06 26.5 0.0 1.3e-05 25.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF43668.1 - 1.2e-05 26.0 0.0 2e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MFS_1 PF07690.16 CCF43669.1 - 4.5e-38 131.1 23.7 6.1e-38 130.6 23.7 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF43669.1 - 2.7e-12 46.3 11.4 4e-12 45.7 11.4 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_2 PF13347.6 CCF43669.1 - 0.00053 18.7 9.8 0.00053 18.7 9.8 1.9 1 1 1 2 2 2 1 MFS/sugar transport protein MFS_4 PF06779.14 CCF43669.1 - 0.0072 15.7 11.9 0.01 15.2 11.9 1.1 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB SPC25 PF06703.11 CCF43669.1 - 0.041 13.7 0.7 0.081 12.7 0.7 1.4 1 0 0 1 1 1 0 Microsomal signal peptidase 25 kDa subunit (SPC25) DEC-1_N PF04625.13 CCF43669.1 - 1.6 7.7 4.1 2.6 7.0 4.1 1.3 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region ketoacyl-synt PF00109.26 CCF43671.1 - 5.3e-73 245.7 0.6 1.3e-72 244.5 0.6 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 CCF43671.1 - 6.8e-35 119.6 0.1 1.7e-34 118.4 0.1 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Acyl_transf_1 PF00698.21 CCF43671.1 - 3.1e-26 92.6 1.2 1.5e-20 73.9 0.7 2.4 2 0 0 2 2 2 2 Acyl transferase domain HTH_51 PF18558.1 CCF43671.1 - 1.3e-23 82.7 0.0 1.7e-22 79.1 0.0 2.4 2 0 0 2 2 2 1 Helix-turn-helix domain PS-DH PF14765.6 CCF43671.1 - 1.4e-19 70.5 0.0 2.7e-19 69.5 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase Methyltransf_12 PF08242.12 CCF43671.1 - 5.6e-16 59.1 0.0 1.8e-15 57.5 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain SAT PF16073.5 CCF43671.1 - 1.2e-13 51.3 0.8 9.5e-11 41.9 0.0 3.2 2 1 0 2 2 2 2 Starter unit:ACP transacylase in aflatoxin biosynthesis PP-binding PF00550.25 CCF43671.1 - 1.6e-11 44.4 0.3 9.6e-11 41.9 0.4 2.4 2 0 0 2 2 2 1 Phosphopantetheine attachment site Methyltransf_23 PF13489.6 CCF43671.1 - 2e-11 44.0 0.0 1.5e-10 41.2 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Abhydrolase_3 PF07859.13 CCF43671.1 - 2.2e-11 44.0 0.0 8.7e-10 38.8 0.0 2.7 1 1 0 2 2 2 1 alpha/beta hydrolase fold Methyltransf_25 PF13649.6 CCF43671.1 - 1.2e-10 41.9 0.1 4e-10 40.3 0.1 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF43671.1 - 3e-09 36.9 0.0 8.5e-09 35.4 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain KAsynt_C_assoc PF16197.5 CCF43671.1 - 5.8e-09 36.4 0.0 1.8e-08 34.8 0.0 1.8 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Peptidase_S9 PF00326.21 CCF43671.1 - 9.3e-09 35.1 0.0 1e-05 25.1 0.0 2.7 3 0 0 3 3 3 2 Prolyl oligopeptidase family Methyltransf_11 PF08241.12 CCF43671.1 - 2.3e-07 31.3 0.0 7.2e-07 29.8 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Thiolase_N PF00108.23 CCF43671.1 - 8.5e-07 28.6 0.1 1.9e-06 27.5 0.1 1.5 1 0 0 1 1 1 1 Thiolase, N-terminal domain Abhydrolase_6 PF12697.7 CCF43671.1 - 0.00032 21.4 1.9 0.00032 21.4 1.9 3.2 2 1 0 2 2 2 1 Alpha/beta hydrolase family ACP_syn_III PF08545.10 CCF43671.1 - 0.018 14.9 0.8 0.28 11.1 0.4 2.6 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III ABC_trans_N PF14510.6 CCF43671.1 - 0.023 15.3 0.0 0.061 13.9 0.0 1.7 1 0 0 1 1 1 0 ABC-transporter N-terminal Methyltransf_33 PF10017.9 CCF43671.1 - 0.036 13.2 0.0 0.077 12.1 0.0 1.4 1 0 0 1 1 1 0 Histidine-specific methyltransferase, SAM-dependent Ubie_methyltran PF01209.18 CCF43671.1 - 0.042 13.2 0.0 0.087 12.1 0.0 1.4 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family DUF829 PF05705.14 CCF43671.1 - 0.071 13.0 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF829) Hydrolase_4 PF12146.8 CCF43671.1 - 0.071 12.4 0.0 0.23 10.7 0.0 1.8 2 0 0 2 2 2 0 Serine aminopeptidase, S33 HTH_6 PF01418.17 CCF43671.1 - 0.075 13.0 0.0 0.19 11.8 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain, rpiR family Methyltransf_28 PF02636.17 CCF43671.1 - 0.15 11.7 0.0 0.25 10.9 0.0 1.3 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase DUF2920 PF11144.8 CCF43671.1 - 0.28 10.3 0.0 0.5 9.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2920) HTH_Tnp_Tc5 PF03221.16 CCF43672.1 - 0.00012 22.0 0.1 0.00021 21.3 0.0 1.5 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 CCF43672.1 - 0.027 14.2 0.0 0.05 13.3 0.0 1.5 1 0 0 1 1 1 0 helix-turn-helix, Psq domain His_Phos_2 PF00328.22 CCF43673.1 - 2.6e-20 73.2 0.0 1.2e-19 71.0 0.0 1.8 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Glyco_hydro_16 PF00722.21 CCF43674.1 - 4.6e-44 150.0 3.6 7.2e-44 149.4 3.6 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 AF-4 PF05110.13 CCF43674.1 - 0.097 10.8 13.9 0.13 10.4 13.9 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Chitin_bind_1 PF00187.19 CCF43674.1 - 4.6 7.8 21.0 0.083 13.4 13.1 2.1 2 0 0 2 2 2 0 Chitin recognition protein DUF3821 PF12863.7 CCF43675.1 - 0.0084 16.0 0.0 0.014 15.3 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3821) DUF4407 PF14362.6 CCF43675.1 - 0.02 14.3 0.0 0.02 14.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Androgen_recep PF02166.16 CCF43675.1 - 2.3 7.0 16.5 3.6 6.3 16.5 1.3 1 0 0 1 1 1 0 Androgen receptor Spt20 PF12090.8 CCF43675.1 - 5.1 6.6 16.1 0.39 10.3 11.1 1.6 2 0 0 2 2 2 0 Spt20 family Suf PF05843.14 CCF43675.1 - 5.9 6.8 15.3 7.7 6.4 15.3 1.3 1 1 0 1 1 1 0 Suppressor of forked protein (Suf) AtuA PF07287.11 CCF43676.1 - 2.6e-114 381.6 0.0 3.1e-114 381.3 0.0 1.1 1 0 0 1 1 1 1 Acyclic terpene utilisation family protein AtuA 3HCDH_N PF02737.18 CCF43678.1 - 0.0033 17.3 1.6 0.0035 17.2 1.6 1.0 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain F420_oxidored PF03807.17 CCF43678.1 - 0.0046 17.5 0.4 0.0048 17.4 0.4 1.1 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 CCF43678.1 - 0.081 13.1 0.5 0.09 12.9 0.5 1.0 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.19 CCF43678.1 - 0.14 11.5 0.4 0.14 11.5 0.4 1.0 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain tRNA-synt_1 PF00133.22 CCF43680.1 - 2.4e-217 723.0 0.0 3.2e-216 719.3 0.0 2.1 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 CCF43680.1 - 7.8e-31 107.1 0.1 2.4e-30 105.5 0.1 1.9 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 CCF43680.1 - 1.6e-11 43.6 0.0 0.00016 20.5 0.0 4.3 4 1 0 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 CCF43680.1 - 1.4e-10 41.0 6.3 4.6e-08 32.8 0.0 3.1 2 1 1 3 3 3 2 Leucyl-tRNA synthetase, Domain 2 Val_tRNA-synt_C PF10458.9 CCF43680.1 - 0.0013 18.9 5.3 0.0013 18.9 5.3 3.7 3 0 0 3 3 3 1 Valyl tRNA synthetase tRNA binding arm SHR3_chaperone PF08229.11 CCF43681.1 - 2.7e-76 254.8 0.0 3e-76 254.6 0.0 1.0 1 0 0 1 1 1 1 ER membrane protein SH3 DUF2157 PF09925.9 CCF43681.1 - 0.09 12.6 0.1 13 5.5 0.1 2.6 2 1 0 2 2 2 0 Predicted membrane protein (DUF2157) DUF5453 PF17534.2 CCF43681.1 - 5.4 6.9 9.1 0.4 10.6 1.3 2.4 2 1 1 3 3 3 0 Family of unknown function (DUF5453) SlyX PF04102.12 CCF43682.1 - 0.005 17.4 0.1 1 10.0 0.0 2.5 2 0 0 2 2 2 2 SlyX UPF0020 PF01170.18 CCF43683.1 - 2.1e-10 40.6 0.0 1.1e-08 35.0 0.0 2.1 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 RPN1_RPN2_N PF17781.1 CCF43684.1 - 1.4e-69 234.9 0.7 6e-43 147.4 1.1 2.4 1 1 1 2 2 2 2 RPN1/RPN2 N-terminal domain RPN1_C PF18051.1 CCF43684.1 - 6.3e-29 99.8 0.0 1.1e-28 99.1 0.0 1.4 1 0 0 1 1 1 1 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal PC_rep PF01851.22 CCF43684.1 - 3.7e-19 68.1 15.3 1.2e-05 25.4 0.3 8.2 7 1 0 7 7 7 4 Proteasome/cyclosome repeat HEAT_2 PF13646.6 CCF43684.1 - 8.8e-08 32.4 0.6 0.0087 16.4 0.0 4.1 4 1 1 5 5 5 3 HEAT repeats HEAT PF02985.22 CCF43684.1 - 0.12 12.7 0.0 21 5.7 0.0 3.9 3 0 0 3 3 3 0 HEAT repeat DLIC PF05783.11 CCF43686.1 - 5.1e-25 88.2 0.0 1.6e-24 86.6 0.0 1.8 1 1 0 1 1 1 1 Dynein light intermediate chain (DLIC) zf-ZPR1 PF03367.13 CCF43687.1 - 9.2e-112 370.1 0.0 3.2e-55 186.3 0.0 2.2 2 0 0 2 2 2 2 ZPR1 zinc-finger domain Lipoprot_C PF08794.10 CCF43687.1 - 0.085 12.9 0.0 0.25 11.3 0.0 1.7 1 0 0 1 1 1 0 Lipoprotein GNA1870 C terminal like DUF2561 PF10812.8 CCF43688.1 - 0.065 13.3 1.7 0.12 12.4 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2561) Popeye PF04831.13 CCF43688.1 - 0.1 12.7 2.6 0.26 11.5 2.6 1.7 1 0 0 1 1 1 0 Popeye protein conserved region Fumarate_red_D PF02313.17 CCF43688.1 - 3.8 7.7 9.3 0.08 13.1 0.8 2.4 2 2 1 3 3 3 0 Fumarate reductase subunit D PDR_CDR PF06422.12 CCF43689.1 - 6.6e-05 22.7 0.1 8.7e-05 22.4 0.1 1.1 1 0 0 1 1 1 1 CDR ABC transporter VASt PF16016.5 CCF43690.1 - 3.4e-37 128.2 0.0 5.7e-37 127.5 0.0 1.4 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain GRAM PF02893.20 CCF43690.1 - 2.9e-24 85.1 0.0 4.7e-24 84.5 0.0 1.3 1 0 0 1 1 1 1 GRAM domain NOA36 PF06524.12 CCF43690.1 - 0.085 12.2 0.6 0.14 11.4 0.6 1.4 1 0 0 1 1 1 0 NOA36 protein Con-6 PF10346.9 CCF43691.1 - 9e-16 57.6 7.4 5.8e-13 48.6 2.9 2.1 2 0 0 2 2 2 2 Conidiation protein 6 Ketoacyl-synt_C PF02801.22 CCF43694.1 - 3.3e-35 120.6 0.0 4.1e-35 120.3 0.0 1.1 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PPR_2 PF13041.6 CCF43695.1 - 0.0004 20.5 0.0 0.0037 17.4 0.0 2.6 2 0 0 2 2 2 1 PPR repeat family PPR_1 PF12854.7 CCF43695.1 - 0.0042 16.7 0.0 0.017 14.8 0.0 2.0 2 0 0 2 2 2 1 PPR repeat PPR_long PF17177.4 CCF43695.1 - 0.0065 15.9 0.0 0.015 14.6 0.0 1.6 1 0 0 1 1 1 1 Pentacotripeptide-repeat region of PRORP PPR_3 PF13812.6 CCF43695.1 - 0.11 12.6 0.0 0.71 10.0 0.0 2.4 3 0 0 3 3 3 0 Pentatricopeptide repeat domain PPR PF01535.20 CCF43695.1 - 0.13 12.5 0.0 0.75 10.2 0.0 2.4 2 0 0 2 2 2 0 PPR repeat GDPD PF03009.17 CCF43696.1 - 5.2e-70 236.1 0.0 1.7e-69 234.4 0.0 1.9 2 0 0 2 2 2 1 Glycerophosphoryl diester phosphodiesterase family Ank_2 PF12796.7 CCF43696.1 - 4.2e-27 94.5 0.1 3.4e-08 34.0 0.1 4.2 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CCF43696.1 - 1.7e-23 82.7 1.3 7.5e-08 32.8 0.1 5.6 4 1 1 5 5 5 4 Ankyrin repeats (many copies) SPX PF03105.19 CCF43696.1 - 3.3e-21 76.6 11.6 1.5e-10 41.6 0.1 3.7 2 1 2 4 4 4 3 SPX domain Ank_5 PF13857.6 CCF43696.1 - 6.4e-17 61.4 1.6 5.7e-06 26.5 0.0 5.7 2 2 3 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCF43696.1 - 6.4e-16 56.8 1.0 0.0082 16.6 0.0 7.4 7 0 0 7 7 7 3 Ankyrin repeat Ank PF00023.30 CCF43696.1 - 2.6e-15 56.1 4.5 0.0024 18.2 0.0 6.3 6 0 0 6 6 6 3 Ankyrin repeat DUF1978 PF09321.10 CCF43696.1 - 0.097 12.0 0.1 0.21 10.8 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1978) Cep57_CLD PF14073.6 CCF43697.1 - 0.00023 21.2 35.3 0.002 18.2 32.8 6.7 3 3 4 7 7 6 2 Centrosome localisation domain of Cep57 Phage_GP20 PF06810.11 CCF43697.1 - 0.00028 20.7 26.0 0.0017 18.2 12.2 8.6 4 2 4 8 8 8 4 Phage minor structural protein GP20 GAS PF13851.6 CCF43697.1 - 0.0033 16.8 113.0 0.055 12.8 19.3 7.0 3 2 3 6 6 6 4 Growth-arrest specific micro-tubule binding Filament PF00038.21 CCF43697.1 - 0.0038 16.9 14.3 0.0038 16.9 14.3 7.3 3 2 4 7 7 7 4 Intermediate filament protein DUF2968 PF11180.8 CCF43697.1 - 0.0095 15.6 8.3 0.0095 15.6 8.3 7.6 4 2 4 8 8 6 1 Protein of unknown function (DUF2968) Spc7 PF08317.11 CCF43697.1 - 0.0097 14.8 116.8 0.012 14.6 12.9 6.3 3 2 3 6 6 6 5 Spc7 kinetochore protein DHR10 PF18595.1 CCF43697.1 - 0.014 15.4 13.0 0.014 15.4 13.0 8.9 4 2 3 8 8 7 0 Designed helical repeat protein 10 domain DUF3800 PF12686.7 CCF43697.1 - 0.025 15.2 0.6 21 5.7 0.6 4.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) Cep57_CLD_2 PF14197.6 CCF43697.1 - 0.036 14.1 0.9 0.036 14.1 0.9 9.6 5 3 3 8 8 6 0 Centrosome localisation domain of PPC89 Fib_alpha PF08702.10 CCF43697.1 - 1.8 8.7 70.6 0.15 12.2 7.2 7.3 3 2 4 7 7 7 0 Fibrinogen alpha/beta chain family TPR_MLP1_2 PF07926.12 CCF43697.1 - 6.2 6.9 126.6 0.04 14.0 16.4 8.1 3 2 3 7 7 7 0 TPR/MLP1/MLP2-like protein CALCOCO1 PF07888.11 CCF43697.1 - 6.4 5.5 109.6 0.19 10.6 27.9 4.4 2 2 2 4 4 4 0 Calcium binding and coiled-coil domain (CALCOCO1) like PI_PP_I PF18363.1 CCF43697.1 - 9 6.6 18.4 3.4 7.9 0.3 5.5 4 2 3 7 7 7 0 Phosphoinositide phosphatase insertion domain TRP PF06011.12 CCF43698.1 - 2.8e-134 448.1 27.8 3.3e-134 447.8 27.8 1.0 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel RNase_Zc3h12a PF11977.8 CCF43699.1 - 0.037 13.8 0.1 0.077 12.8 0.1 1.6 1 1 0 1 1 1 0 Zc3h12a-like Ribonuclease NYN domain ABC2_membrane PF01061.24 CCF43700.1 - 5.7e-15 55.3 8.7 5.7e-15 55.3 8.7 1.6 2 0 0 2 2 2 1 ABC-2 type transporter ABC2_membrane_3 PF12698.7 CCF43700.1 - 2.2e-05 23.7 16.8 2.5e-05 23.6 16.8 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein PDR_CDR PF06422.12 CCF43700.1 - 0.026 14.4 0.1 0.026 14.4 0.1 1.8 2 0 0 2 2 2 0 CDR ABC transporter ABC2_membrane_2 PF12679.7 CCF43700.1 - 0.09 12.0 10.1 0.11 11.7 10.1 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein EamA PF00892.20 CCF43700.1 - 0.55 10.4 14.2 0.055 13.6 6.9 2.3 2 1 0 2 2 2 0 EamA-like transporter family ThrE PF06738.12 CCF43700.1 - 2.3 7.5 9.7 0.67 9.3 7.1 1.6 1 1 0 1 1 1 0 Putative threonine/serine exporter dbPDZ_assoc PF16610.5 CCF43701.1 - 0.12 12.6 1.2 0.15 12.3 1.2 1.2 1 0 0 1 1 1 0 Unstructured region between two PDZ domains on Dlg5 FAA_hydrolase PF01557.18 CCF43702.1 - 9.4e-58 195.4 0.0 1.3e-57 195.0 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FAA_hydrolase_N PF09298.11 CCF43702.1 - 9.1e-34 115.9 0.0 1.7e-33 115.0 0.0 1.5 1 0 0 1 1 1 1 Fumarylacetoacetase N-terminal Glyco_hydro_18 PF00704.28 CCF43703.1 - 4.2e-65 220.5 0.0 4.9e-65 220.3 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 TMEM135_C_rich PF15982.5 CCF43705.1 - 0.0072 16.9 0.6 0.038 14.6 0.6 2.2 1 1 0 1 1 1 1 N-terminal cysteine-rich region of Transmembrane protein 135 HLH PF00010.26 CCF43706.1 - 1.4e-07 31.3 0.1 3.9e-07 29.9 0.0 1.8 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain Epimerase PF01370.21 CCF43708.1 - 6.6e-09 35.6 0.0 8e-09 35.3 0.0 1.0 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CCF43708.1 - 5.5e-07 29.6 0.0 7.5e-07 29.2 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding HIM1 PF08732.10 CCF43708.1 - 0.0031 17.1 0.0 0.0043 16.6 0.0 1.2 1 0 0 1 1 1 1 HIM1 Semialdhyde_dh PF01118.24 CCF43708.1 - 0.0071 16.8 0.1 0.027 14.9 0.1 1.8 1 1 1 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 CCF43708.1 - 0.021 13.9 0.0 0.087 11.8 0.0 1.8 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family NmrA PF05368.13 CCF43708.1 - 0.026 14.1 1.1 0.33 10.5 1.1 2.0 1 1 0 1 1 1 0 NmrA-like family DUF4870 PF09685.10 CCF43709.1 - 0.32 11.1 9.9 0.056 13.6 5.6 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4870) MAPEG PF01124.18 CCF43710.1 - 2.5e-15 56.5 0.5 3.1e-15 56.2 0.5 1.1 1 0 0 1 1 1 1 MAPEG family BTP PF05232.12 CCF43710.1 - 0.016 15.3 0.2 0.043 13.9 0.0 1.8 2 0 0 2 2 2 0 Chlorhexidine efflux transporter CLN3 PF02487.17 CCF43712.1 - 4.7e-17 62.1 0.4 5.5e-17 61.9 0.4 1.0 1 0 0 1 1 1 1 CLN3 protein MFS_1 PF07690.16 CCF43712.1 - 0.013 14.5 11.1 0.015 14.2 11.1 1.2 1 0 0 1 1 1 0 Major Facilitator Superfamily COX16 PF14138.6 CCF43712.1 - 0.095 13.2 0.0 0.15 12.6 0.0 1.3 1 0 0 1 1 1 0 Cytochrome c oxidase assembly protein COX16 Ribosomal_S2 PF00318.20 CCF43713.1 - 0.082 12.1 0.0 0.13 11.5 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein S2 p450 PF00067.22 CCF43714.1 - 4.3e-42 144.4 0.0 5.3e-42 144.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 adh_short_C2 PF13561.6 CCF43717.1 - 1.8e-43 148.8 0.1 2.3e-43 148.4 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF43717.1 - 7.9e-34 116.8 0.0 1.4e-33 116.0 0.0 1.4 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 CCF43717.1 - 2e-05 24.6 0.0 3e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 KR domain PEPCK_ATP PF01293.20 CCF43718.1 - 4.4e-12 45.4 0.0 5.2e-12 45.2 0.0 1.1 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase AMP-binding PF00501.28 CCF43719.1 - 2e-91 306.7 0.1 2.6e-91 306.4 0.1 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CCF43719.1 - 8.6e-12 45.9 0.1 1.7e-11 44.9 0.1 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain MazE_antitoxin PF04014.18 CCF43719.1 - 0.074 13.0 0.0 12 6.0 0.0 2.4 2 0 0 2 2 2 0 Antidote-toxin recognition MazE, bacterial antitoxin Abhydrolase_1 PF00561.20 CCF43720.1 - 1.2e-13 51.4 0.1 2.4e-13 50.3 0.1 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCF43720.1 - 4.5e-06 27.4 3.8 6.1e-06 27.0 3.8 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCF43720.1 - 8.7e-06 25.2 0.2 0.0054 16.0 0.2 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 AtuA PF07287.11 CCF43721.1 - 1.6e-62 211.3 0.1 2e-62 211.0 0.1 1.0 1 0 0 1 1 1 1 Acyclic terpene utilisation family protein AtuA MFS_1 PF07690.16 CCF43722.1 - 1.1e-20 73.9 19.4 1.3e-20 73.6 19.4 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF43722.1 - 2.4e-06 26.7 2.9 2.7e-06 26.5 2.9 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter CBM_1 PF00734.18 CCF43723.1 - 6.4e-11 42.0 11.2 6.4e-11 42.0 11.2 2.3 3 0 0 3 3 3 1 Fungal cellulose binding domain AAA_11 PF13086.6 CCF43724.1 - 2.1e-51 175.2 3.0 3.2e-30 105.8 0.2 2.2 1 1 1 2 2 2 2 AAA domain AAA_12 PF13087.6 CCF43724.1 - 6.8e-39 133.6 0.0 1.1e-38 132.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain DUF5599 PF18141.1 CCF43724.1 - 9.1e-34 115.6 0.1 4.9e-33 113.2 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF5599) AAA_30 PF13604.6 CCF43724.1 - 4.1e-14 52.7 0.0 8.7e-14 51.7 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CCF43724.1 - 1.9e-10 41.3 0.0 6.1e-10 39.6 0.0 1.8 1 1 0 1 1 1 1 AAA domain PIF1 PF05970.14 CCF43724.1 - 9.1e-07 28.4 0.0 1.3e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 PIF1-like helicase ResIII PF04851.15 CCF43724.1 - 7.1e-06 26.1 0.0 1.4e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_RecD PF05127.14 CCF43724.1 - 2.4e-05 24.2 0.0 4.1e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Helicase UvrD-helicase PF00580.21 CCF43724.1 - 0.00011 21.9 0.0 0.005 16.4 0.0 2.3 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain DEAD PF00270.29 CCF43724.1 - 0.00065 19.5 0.1 0.0012 18.7 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF2075 PF09848.9 CCF43724.1 - 0.002 17.5 0.0 0.0043 16.3 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) ATPase PF06745.13 CCF43724.1 - 0.0044 16.4 0.0 0.009 15.4 0.0 1.5 1 0 0 1 1 1 1 KaiC AAA_22 PF13401.6 CCF43724.1 - 0.0062 16.8 0.0 0.033 14.4 0.0 1.9 1 1 0 2 2 2 1 AAA domain SRP54 PF00448.22 CCF43724.1 - 0.012 15.2 0.0 0.031 13.9 0.0 1.6 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_10 PF12846.7 CCF43724.1 - 0.016 14.2 0.0 0.027 13.4 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain PhoH PF02562.16 CCF43724.1 - 0.027 13.9 0.0 0.11 12.0 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein AAA_16 PF13191.6 CCF43724.1 - 0.045 14.1 0.0 0.074 13.4 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA PF00004.29 CCF43724.1 - 0.059 13.8 0.0 0.11 12.9 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Helicase_C_2 PF13307.6 CCF43724.1 - 0.1 12.8 0.0 0.27 11.4 0.0 1.7 1 0 0 1 1 1 0 Helicase C-terminal domain FAM70 PF14967.6 CCF43725.1 - 0.17 11.3 0.2 0.18 11.3 0.2 1.0 1 0 0 1 1 1 0 FAM70 protein Peptidase_S8 PF00082.22 CCF43726.1 - 1.1e-16 60.9 0.7 1.1e-16 60.9 0.7 2.0 2 0 0 2 2 2 1 Subtilase family SPX PF03105.19 CCF43726.1 - 0.0018 18.3 1.6 0.0032 17.4 1.6 1.4 1 0 0 1 1 1 1 SPX domain ABC_membrane PF00664.23 CCF43727.1 - 5.7e-38 131.1 20.7 7.1e-38 130.8 20.7 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 CCF43727.1 - 2.2e-15 57.4 0.1 7.5e-14 52.4 0.1 2.2 1 1 0 1 1 1 1 ABC transporter RsgA_GTPase PF03193.16 CCF43727.1 - 6.6e-06 26.1 0.1 1.1e-05 25.4 0.1 1.2 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 CCF43727.1 - 0.00013 21.6 0.2 0.00033 20.3 0.2 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_30 PF13604.6 CCF43727.1 - 0.0048 16.6 0.1 0.01 15.6 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_23 PF13476.6 CCF43727.1 - 0.0057 17.2 1.6 0.018 15.6 1.7 1.7 1 1 0 1 1 1 1 AAA domain AAA_15 PF13175.6 CCF43727.1 - 0.0069 16.1 0.1 0.01 15.6 0.1 1.2 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 CCF43727.1 - 0.0098 16.2 0.2 0.027 14.7 0.1 1.6 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CCF43727.1 - 0.014 15.8 0.0 0.027 14.8 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain AAA_21 PF13304.6 CCF43727.1 - 0.03 14.1 0.0 0.048 13.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CCF43727.1 - 0.033 13.6 0.0 0.053 12.9 0.0 1.3 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_33 PF13671.6 CCF43727.1 - 0.17 12.0 0.0 0.34 11.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain Baculo_11_kDa PF06143.11 CCF43727.1 - 4.5 6.9 5.0 1.3 8.6 0.2 2.3 2 0 0 2 2 2 0 Baculovirus 11 kDa family Glyco_hydro_3_C PF01915.22 CCF43728.1 - 0.063 13.2 1.4 0.073 13.0 0.9 1.4 2 0 0 2 2 2 0 Glycosyl hydrolase family 3 C-terminal domain RTA1 PF04479.13 CCF43729.1 - 5.8e-75 251.4 6.1 5.8e-75 251.4 6.1 1.6 2 0 0 2 2 2 1 RTA1 like protein Tax PF02959.16 CCF43729.1 - 0.027 13.9 0.6 0.045 13.2 0.1 1.6 2 0 0 2 2 2 0 HTLV Tax COX2_TM PF02790.15 CCF43729.1 - 0.069 13.3 0.5 0.069 13.3 0.5 2.3 3 0 0 3 3 3 0 Cytochrome C oxidase subunit II, transmembrane domain DUF3522 PF12036.8 CCF43729.1 - 0.24 11.7 6.9 4.6 7.5 0.9 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3522) LHC PF00556.20 CCF43729.1 - 0.77 10.0 6.9 1.5 9.1 0.2 2.8 2 0 0 2 2 2 0 Antenna complex alpha/beta subunit GlpM PF06942.12 CCF43729.1 - 3.2 8.2 11.2 0.077 13.4 2.7 2.3 2 1 0 2 2 2 0 GlpM protein DUF2235 PF09994.9 CCF43730.1 - 8.6e-95 317.4 0.6 1.3e-94 316.8 0.6 1.3 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) An_peroxidase PF03098.15 CCF43731.1 - 2.8e-20 72.4 0.1 8.5e-12 44.4 0.0 3.4 3 1 0 3 3 3 2 Animal haem peroxidase PI_PP_C PF18365.1 CCF43731.1 - 0.053 13.5 0.2 0.12 12.3 0.2 1.6 1 0 0 1 1 1 0 Phosphoinositide phosphatase C-terminal domain FMN_dh PF01070.18 CCF43734.1 - 1.6e-105 353.0 0.1 2e-105 352.7 0.1 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 CCF43734.1 - 3.3e-18 65.6 0.0 6.1e-18 64.8 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.17 CCF43734.1 - 0.00071 18.8 0.0 0.0012 18.0 0.0 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 CCF43734.1 - 0.00085 18.4 0.3 0.003 16.6 0.3 1.8 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.15 CCF43734.1 - 0.0059 16.0 0.2 0.012 15.0 0.1 1.5 1 1 0 1 1 1 1 Nitronate monooxygenase Peptidase_M19 PF01244.21 CCF43734.1 - 0.18 11.0 0.0 0.72 9.0 0.0 2.1 3 1 0 3 3 3 0 Membrane dipeptidase (Peptidase family M19) DUF4202 PF13875.6 CCF43735.1 - 1.2e-75 253.5 0.2 1.4e-75 253.3 0.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4202) SKG6 PF08693.10 CCF43736.1 - 0.025 14.0 2.7 0.074 12.5 2.7 1.8 1 0 0 1 1 1 0 Transmembrane alpha-helix domain DUF2681 PF10883.8 CCF43736.1 - 0.028 14.8 0.6 0.054 13.9 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) Adeno_E3_CR2 PF02439.15 CCF43736.1 - 0.06 13.1 1.6 2.7 7.8 0.1 2.4 2 0 0 2 2 2 0 Adenovirus E3 region protein CR2 EphA2_TM PF14575.6 CCF43736.1 - 0.079 13.9 0.0 0.18 12.7 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF2613 PF11021.8 CCF43736.1 - 0.23 11.6 3.5 3.8 7.7 0.1 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2613) Syndecan PF01034.20 CCF43736.1 - 0.25 11.3 0.2 0.66 9.9 0.0 1.7 2 0 0 2 2 2 0 Syndecan domain CcmD PF04995.14 CCF43736.1 - 1.3 9.2 4.4 0.87 9.7 0.6 2.4 2 0 0 2 2 2 0 Heme exporter protein D (CcmD) Synaptobrevin PF00957.21 CCF43737.1 - 2.9e-32 110.3 0.5 3.8e-32 109.9 0.5 1.2 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 CCF43737.1 - 5.8e-30 103.2 0.0 1.1e-29 102.3 0.0 1.5 1 0 0 1 1 1 1 Regulated-SNARE-like domain NAD_binding_8 PF13450.6 CCF43739.1 - 1.5e-06 28.4 0.2 2.2e-06 27.8 0.2 1.3 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 CCF43739.1 - 0.0021 18.0 0.5 0.0031 17.5 0.2 1.4 2 0 0 2 2 2 1 FAD-NAD(P)-binding DAO PF01266.24 CCF43739.1 - 0.0036 16.9 0.8 0.0056 16.3 0.8 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 CCF43739.1 - 0.038 13.3 0.9 0.048 12.9 0.9 1.1 1 0 0 1 1 1 0 FAD binding domain ThiF PF00899.21 CCF43739.1 - 0.18 11.1 0.0 0.25 10.7 0.0 1.2 1 0 0 1 1 1 0 ThiF family TAF PF02969.17 CCF43741.1 - 7.5e-14 51.7 0.0 9.1e-14 51.4 0.0 1.1 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) Acyltransferase PF01553.21 CCF43742.1 - 9.5e-15 54.4 0.0 1.3e-14 53.9 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 CCF43742.1 - 1.4e-10 41.1 0.1 4.1e-10 39.6 0.1 1.7 1 0 0 1 1 1 1 Acyltransferase C-terminus LAL_C2 PF18603.1 CCF43742.1 - 0.0021 18.2 0.0 0.0033 17.5 0.0 1.3 1 0 0 1 1 1 1 L-amino acid ligase C-terminal domain 2 Aa_trans PF01490.18 CCF43743.1 - 1.2e-82 277.8 29.4 1.5e-82 277.5 29.4 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Voltage_CLC PF00654.20 CCF43745.1 - 5e-87 292.4 26.9 5e-87 292.4 26.9 1.8 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 CCF43745.1 - 8.2e-11 42.2 0.1 3.4e-05 24.2 0.0 2.6 2 0 0 2 2 2 2 CBS domain EamA PF00892.20 CCF43746.1 - 0.00066 19.9 14.7 0.0072 16.5 14.7 2.0 1 1 0 1 1 1 1 EamA-like transporter family Trp_oprn_chp PF09534.10 CCF43746.1 - 0.0083 15.9 0.0 0.94 9.2 0.0 2.1 2 0 0 2 2 2 2 Tryptophan-associated transmembrane protein (Trp_oprn_chp) TMEM234 PF10639.9 CCF43746.1 - 0.028 14.5 3.3 0.044 13.8 3.1 1.3 1 1 0 1 1 1 0 Putative transmembrane family 234 TFIIA_gamma_C PF02751.14 CCF43747.1 - 4.4e-24 84.3 0.9 7.2e-24 83.7 0.9 1.3 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit TFIIA_gamma_N PF02268.16 CCF43747.1 - 2.5e-23 81.8 0.3 3.4e-23 81.4 0.3 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit, helical domain NOA36 PF06524.12 CCF43747.1 - 0.16 11.3 0.0 0.18 11.1 0.0 1.1 1 0 0 1 1 1 0 NOA36 protein ATP-synt_C PF00137.21 CCF43748.1 - 9.9e-25 86.7 34.6 4.9e-15 55.6 10.7 2.9 3 0 0 3 3 3 2 ATP synthase subunit C SLATT_5 PF18160.1 CCF43748.1 - 0.26 10.6 0.9 0.53 9.6 0.0 1.8 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 MoCF_biosynth PF00994.24 CCF43749.1 - 2e-52 176.7 0.8 2.6e-27 95.3 0.0 2.4 2 0 0 2 2 2 2 Probable molybdopterin binding domain MoeA_N PF03453.17 CCF43749.1 - 9.1e-40 136.0 1.6 9.1e-40 136.0 1.6 1.6 2 0 0 2 2 2 1 MoeA N-terminal region (domain I and II) MoeA_C PF03454.15 CCF43749.1 - 3.1e-16 59.3 0.0 8e-16 58.0 0.0 1.8 1 0 0 1 1 1 1 MoeA C-terminal region (domain IV) Phage_Coat_B PF05356.11 CCF43749.1 - 0.069 13.1 0.1 0.23 11.4 0.1 1.9 1 0 0 1 1 1 0 Phage Coat protein B GST_N_3 PF13417.6 CCF43751.1 - 1.3e-10 41.5 0.1 3e-10 40.3 0.1 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CCF43751.1 - 0.0023 18.2 0.1 0.0066 16.7 0.1 1.9 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CCF43751.1 - 0.0036 17.3 0.0 0.0061 16.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain DUF150_C PF17384.2 CCF43751.1 - 0.0039 17.3 0.0 0.01 16.0 0.0 1.7 1 0 0 1 1 1 1 RimP C-terminal SH3 domain GST_C PF00043.25 CCF43751.1 - 0.06 13.6 0.0 0.11 12.7 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Aft1_HRR PF11787.8 CCF43752.1 - 1.2e-28 100.1 7.0 1.2e-28 100.1 7.0 3.8 5 0 0 5 5 5 1 Aft1 HRR domain Aft1_HRA PF11786.8 CCF43752.1 - 7.1e-24 83.9 10.0 7.1e-24 83.9 10.0 3.1 2 0 0 2 2 2 1 Aft1 HRA domain Aft1_OSA PF11785.8 CCF43752.1 - 2.5e-21 75.9 6.4 2.5e-21 75.9 6.4 4.4 6 1 0 6 6 6 1 Aft1 osmotic stress response (OSM) domain bZIP_1 PF00170.21 CCF43752.1 - 1.4e-12 47.5 6.2 2.3e-12 46.8 6.2 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 CCF43752.1 - 4.4e-06 26.7 6.2 9.1e-06 25.7 6.2 1.5 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 CCF43752.1 - 0.0032 18.0 3.1 0.0032 18.0 3.1 2.6 3 0 0 3 3 3 1 bZIP Maf transcription factor HALZ PF02183.18 CCF43752.1 - 0.13 12.5 0.1 0.25 11.6 0.1 1.4 1 0 0 1 1 1 0 Homeobox associated leucine zipper MIS13 PF08202.11 CCF43753.1 - 1.4e-59 201.8 4.2 2.4e-59 201.1 4.2 1.3 1 0 0 1 1 1 1 Mis12-Mtw1 protein family DUF5082 PF16888.5 CCF43753.1 - 0.0018 18.6 6.1 0.35 11.2 0.1 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF5082) LPP PF04728.13 CCF43753.1 - 0.019 15.4 1.1 0.39 11.1 0.1 2.4 2 0 0 2 2 2 0 Lipoprotein leucine-zipper ZapB PF06005.12 CCF43753.1 - 0.023 15.1 8.6 1.6 9.3 0.4 2.6 2 0 0 2 2 2 0 Cell division protein ZapB ATF7IP_BD PF16788.5 CCF43753.1 - 0.036 14.2 8.9 0.099 12.7 1.6 2.6 2 0 0 2 2 2 0 ATF-interacting protein binding domain Fungal_TACC PF12709.7 CCF43753.1 - 0.062 13.7 4.0 8 7.0 2.0 2.5 2 0 0 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins DivIC PF04977.15 CCF43753.1 - 1.2 9.0 5.2 6.8 6.5 2.2 2.4 2 0 0 2 2 2 0 Septum formation initiator XhlA PF10779.9 CCF43753.1 - 5.2 7.4 5.3 23 5.3 1.5 3.1 2 1 0 3 3 3 0 Haemolysin XhlA Sdh5 PF03937.16 CCF43754.1 - 3.8e-24 84.5 0.4 1.4e-23 82.7 0.2 1.9 2 0 0 2 2 2 1 Flavinator of succinate dehydrogenase DPRP PF04244.13 CCF43754.1 - 0.042 13.7 0.0 0.058 13.2 0.0 1.2 1 0 0 1 1 1 0 Deoxyribodipyrimidine photo-lyase-related protein EMP24_GP25L PF01105.24 CCF43755.1 - 1e-40 139.6 0.0 1.1e-40 139.5 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD EzrA PF06160.12 CCF43755.1 - 0.036 12.2 0.6 0.048 11.8 0.6 1.0 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA zf-U1 PF06220.12 CCF43756.1 - 6.4e-22 77.0 3.4 9.5e-22 76.5 3.4 1.3 1 0 0 1 1 1 1 U1 zinc finger Bactofilin PF04519.13 CCF43757.1 - 4.9e-08 33.2 6.2 1.4e-05 25.3 0.9 2.2 1 1 1 2 2 2 2 Polymer-forming cytoskeletal FapA PF03961.13 CCF43757.1 - 0.045 12.4 2.6 0.12 10.9 2.6 1.6 1 1 0 1 1 1 0 Flagellar Assembly Protein A MinC_C PF03775.16 CCF43757.1 - 0.18 11.8 2.5 13 5.9 0.0 2.3 1 1 1 2 2 2 0 Septum formation inhibitor MinC, C-terminal domain ING PF12998.7 CCF43758.1 - 0.0022 18.6 0.0 0.0058 17.2 0.0 1.7 2 0 0 2 2 2 1 Inhibitor of growth proteins N-terminal histone-binding TINF2_N PF14973.6 CCF43758.1 - 0.12 12.7 0.0 0.16 12.3 0.0 1.1 1 0 0 1 1 1 0 TERF1-interacting nuclear factor 2 N-terminus P_proprotein PF01483.20 CCF43759.1 - 0.0042 17.1 0.2 0.0061 16.6 0.2 1.3 1 0 0 1 1 1 1 Proprotein convertase P-domain AIMP2_LysRS_bd PF16780.5 CCF43759.1 - 0.19 11.5 0.7 0.33 10.7 0.7 1.3 1 0 0 1 1 1 0 AIMP2 lysyl-tRNA synthetase binding domain zf-C2H2 PF00096.26 CCF43760.1 - 6.1e-06 26.4 4.5 1.6e-05 25.1 4.5 1.8 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-met PF12874.7 CCF43760.1 - 6.2e-06 26.4 1.3 1.3e-05 25.4 1.3 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 CCF43760.1 - 3.4e-05 23.7 2.4 8.4e-05 22.5 2.4 1.7 1 0 0 1 1 1 1 C2H2-type zinc finger zf-H2C2_2 PF13465.6 CCF43760.1 - 0.00021 21.6 7.3 0.14 12.7 1.3 2.5 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2_jaz PF12171.8 CCF43760.1 - 0.00038 20.7 2.4 0.00078 19.7 2.4 1.5 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 CCF43760.1 - 0.00092 19.9 3.2 0.00092 19.9 3.2 2.1 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_2 PF12756.7 CCF43760.1 - 0.0039 17.5 0.1 0.0072 16.6 0.1 1.4 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) RAP1 PF07218.11 CCF43760.1 - 1.8 6.7 3.5 2.4 6.3 3.5 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) AICARFT_IMPCHas PF01808.18 CCF43761.1 - 0.15 11.5 0.1 0.18 11.2 0.1 1.1 1 0 0 1 1 1 0 AICARFT/IMPCHase bienzyme Fer4 PF00037.27 CCF43762.1 - 1.6e-13 49.8 16.5 6e-08 32.2 3.6 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.7 CCF43762.1 - 9.3e-13 48.6 10.2 1.5e-12 47.9 10.2 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_16 PF13484.6 CCF43762.1 - 1.8e-10 41.6 7.0 7.8e-05 23.5 0.3 2.5 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_21 PF14697.6 CCF43762.1 - 1.3e-09 38.0 31.2 5.4e-06 26.4 12.1 2.1 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_10 PF13237.6 CCF43762.1 - 1.6e-08 34.5 21.4 3e-06 27.2 12.4 2.0 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.6 CCF43762.1 - 4e-08 33.3 10.0 8.7e-08 32.2 10.0 1.5 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 CCF43762.1 - 1e-06 29.1 19.9 0.00022 21.6 11.4 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_6 PF12837.7 CCF43762.1 - 1.5e-06 28.0 17.1 0.00039 20.4 5.4 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_2 PF12797.7 CCF43762.1 - 4.7e-06 26.4 11.8 0.0097 16.0 1.7 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_4 PF12800.7 CCF43762.1 - 9e-06 25.8 11.4 0.00029 21.1 1.8 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.6 CCF43762.1 - 0.00032 21.2 11.6 0.043 14.4 12.5 2.4 1 1 2 3 3 3 3 4Fe-4S dicluster domain c-SKI_SMAD_bind PF08782.10 CCF43762.1 - 0.0058 16.8 5.5 0.79 10.0 0.5 2.3 1 1 1 2 2 2 2 c-SKI Smad4 binding domain ETF_QO PF05187.13 CCF43762.1 - 0.046 13.9 5.3 0.2 11.8 0.4 2.3 1 1 1 2 2 2 0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Fer4_18 PF13746.6 CCF43762.1 - 0.07 13.3 8.8 1.2 9.4 1.6 2.2 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_13 PF13370.6 CCF43762.1 - 0.074 13.6 15.1 0.74 10.4 4.3 2.6 2 1 1 3 3 3 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_3 PF12798.7 CCF43762.1 - 0.24 12.4 15.5 0.42 11.7 3.3 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_22 PF17179.4 CCF43762.1 - 0.64 10.9 11.8 3.5 8.5 1.9 2.4 1 1 1 2 2 2 0 4Fe-4S dicluster domain TraW_N PF12477.8 CCF43763.1 - 3.9 7.6 11.3 0.22 11.5 4.6 2.4 3 0 0 3 3 3 0 Sex factor F TraW protein N terminal Glyco_transf_52 PF07922.11 CCF43764.1 - 0.03 13.6 0.0 0.035 13.4 0.0 1.1 1 0 0 1 1 1 0 Glycosyltransferase family 52 Sugar_tr PF00083.24 CCF43765.1 - 6.8e-33 114.2 18.1 7.6e-33 114.0 18.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter TcpE PF12648.7 CCF43765.1 - 2.6 8.6 7.4 18 5.9 5.4 2.6 2 1 0 2 2 2 0 TcpE family Ferritin_2 PF13668.6 CCF43768.1 - 8e-17 61.7 0.0 1.2e-16 61.1 0.0 1.3 1 0 0 1 1 1 1 Ferritin-like domain TMEM189_B_dmain PF10520.9 CCF43768.1 - 0.079 13.1 0.0 0.13 12.4 0.0 1.3 1 0 0 1 1 1 0 B domain of TMEM189, localisation domain CYYR1 PF10873.8 CCF43768.1 - 0.68 10.4 3.1 1.1 9.7 2.9 1.5 1 1 0 1 1 1 0 Cysteine and tyrosine-rich protein 1 MFS_1 PF07690.16 CCF43769.1 - 1.8e-22 79.7 15.6 2.3e-22 79.4 15.6 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF43769.1 - 2e-12 46.8 3.0 2e-12 46.8 3.0 1.3 1 1 0 1 1 1 1 Sugar (and other) transporter TRI12 PF06609.13 CCF43769.1 - 2.7e-07 29.4 3.4 3.4e-07 29.1 3.4 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_2 PF13347.6 CCF43769.1 - 0.014 13.9 6.1 0.024 13.2 6.1 1.4 1 1 0 1 1 1 0 MFS/sugar transport protein zf-C3HC4 PF00097.25 CCF43770.1 - 2.4e-08 33.7 4.9 4.1e-08 33.0 4.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CCF43770.1 - 2.3e-07 30.7 3.4 2.6e-07 30.5 2.3 1.7 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 CCF43770.1 - 8e-07 28.8 3.2 1.6e-06 27.9 3.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CCF43770.1 - 2.3e-06 27.8 5.5 4.1e-06 27.0 5.5 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 CCF43770.1 - 4.6e-06 26.5 2.9 8.5e-06 25.6 2.9 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 CCF43770.1 - 9.2e-06 25.7 3.2 2.3e-05 24.5 3.3 1.7 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 CCF43770.1 - 1.7e-05 24.5 5.6 2e-05 24.3 1.9 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CCF43770.1 - 0.0035 17.2 7.6 0.018 14.9 7.4 2.2 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 CCF43770.1 - 0.054 13.8 3.1 0.14 12.4 3.1 1.7 1 1 0 1 1 1 0 RING-H2 zinc finger domain TerY_C PF15616.6 CCF43770.1 - 0.49 10.5 2.1 0.54 10.4 0.5 1.8 2 0 0 2 2 2 0 TerY-C metal binding domain zf-MIZ PF02891.20 CCF43770.1 - 0.61 9.9 4.7 2.6 7.9 4.4 2.2 1 1 1 2 2 2 0 MIZ/SP-RING zinc finger zf-RING_10 PF16685.5 CCF43770.1 - 0.74 10.0 5.3 2.1 8.6 5.3 1.8 1 1 0 1 1 1 0 zinc RING finger of MSL2 zf-RING_11 PF17123.5 CCF43770.1 - 0.83 9.5 4.1 2.5 7.9 4.1 1.9 1 1 0 1 1 1 0 RING-like zinc finger DUF3433 PF11915.8 CCF43771.1 - 6.3e-12 45.8 24.4 3.7e-09 36.9 0.1 4.4 4 1 0 4 4 4 3 Protein of unknown function (DUF3433) Pectate_lyase PF03211.13 CCF43774.1 - 2.2e-66 223.3 5.3 2.5e-66 223.1 5.3 1.0 1 0 0 1 1 1 1 Pectate lyase WD40 PF00400.32 CCF43775.1 - 9.1e-18 64.3 13.1 0.0014 19.4 0.1 6.6 7 0 0 7 7 7 5 WD domain, G-beta repeat Nup160 PF11715.8 CCF43775.1 - 0.0012 17.6 2.7 0.0038 15.9 0.1 2.3 2 0 0 2 2 2 1 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 CCF43775.1 - 0.069 13.5 0.2 0.49 10.7 0.0 2.5 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain TRF PF08558.10 CCF43778.1 - 3.9e-26 92.1 1.1 7.1e-26 91.3 1.1 1.3 1 0 0 1 1 1 1 Telomere repeat binding factor (TRF) Myb_DNA-binding PF00249.31 CCF43778.1 - 1.1e-05 25.5 0.0 2.5e-05 24.4 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CCF43778.1 - 0.039 14.2 0.0 0.083 13.2 0.0 1.5 1 0 0 1 1 1 0 Myb-like DNA-binding domain PAP2 PF01569.21 CCF43780.1 - 0.048 13.4 3.3 0.076 12.8 0.0 2.2 2 0 0 2 2 2 0 PAP2 superfamily TRI5 PF06330.11 CCF43781.1 - 2.4e-06 26.7 0.0 3.1e-06 26.3 0.0 1.0 1 0 0 1 1 1 1 Trichodiene synthase (TRI5) RRM_1 PF00076.22 CCF43782.1 - 5.2e-60 199.2 0.0 3.3e-21 74.9 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CCF43782.1 - 5.1e-10 39.0 0.0 4.4e-06 26.3 0.0 3.1 2 1 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CCF43782.1 - 5.3e-10 39.0 0.0 0.0059 16.4 0.0 3.3 3 0 0 3 3 3 2 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 CCF43782.1 - 2e-07 30.9 0.1 0.12 12.4 0.0 3.5 3 0 0 3 3 3 2 Nup53/35/40-type RNA recognition motif Cas_Cas2CT1978 PF09707.10 CCF43782.1 - 0.0002 21.4 0.0 0.43 10.7 0.0 2.3 2 0 0 2 2 2 2 CRISPR-associated protein (Cas_Cas2CT1978) RRM_7 PF16367.5 CCF43782.1 - 0.00082 19.4 0.1 0.58 10.3 0.0 3.2 3 1 0 3 3 3 1 RNA recognition motif RRM_8 PF11835.8 CCF43782.1 - 0.0012 19.0 0.0 0.47 10.7 0.0 2.3 2 0 0 2 2 2 2 RRM-like domain RRM_3 PF08777.11 CCF43782.1 - 0.06 13.4 0.0 0.9 9.6 0.0 2.2 2 0 0 2 2 2 0 RNA binding motif SET_assoc PF11767.8 CCF43782.1 - 0.2 11.3 0.0 21 4.8 0.0 2.3 2 0 0 2 2 2 0 Histone lysine methyltransferase SET associated ALG3 PF05208.13 CCF43783.1 - 6.9e-68 229.7 5.1 7.9e-68 229.5 5.1 1.0 1 0 0 1 1 1 1 ALG3 protein eIF-1a PF01176.19 CCF43784.1 - 1.3e-20 72.9 0.0 1.7e-20 72.6 0.0 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 GATase_4 PF13230.6 CCF43785.1 - 5.4e-17 61.6 0.0 6e-14 51.6 0.0 2.1 2 0 0 2 2 2 2 Glutamine amidotransferases class-II GATase_6 PF13522.6 CCF43785.1 - 2e-08 34.5 0.0 3.3e-08 33.8 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain Hepar_II_III PF07940.13 CCF43786.1 - 0.12 12.0 0.0 0.44 10.1 0.0 1.7 1 1 1 2 2 2 0 Heparinase II/III-like protein 2-Hacid_dh PF00389.30 CCF43787.1 - 1.5e-30 105.6 0.0 1.8e-30 105.3 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 2-Hacid_dh_C PF02826.19 CCF43787.1 - 1.1e-05 24.9 0.1 2.3e-05 23.9 0.1 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Amdase PF17645.1 CCF43787.1 - 0.024 14.2 0.1 0.037 13.6 0.1 1.2 1 0 0 1 1 1 0 Arylmalonate decarboxylase GRDP-like PF07173.12 CCF43788.1 - 2.9e-19 70.1 1.2 2.1e-13 51.1 0.1 2.7 2 1 0 2 2 2 2 Glycine-rich domain-containing protein-like MoCF_biosynth PF00994.24 CCF43789.1 - 4.9e-35 120.3 0.0 8.3e-35 119.6 0.0 1.3 1 0 0 1 1 1 1 Probable molybdopterin binding domain Cofilin_ADF PF00241.20 CCF43790.1 - 7.3e-18 64.5 0.0 8.9e-18 64.2 0.0 1.1 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein CPSase_L_D2 PF02786.17 CCF43792.1 - 1.1e-51 175.3 0.0 2.1e-51 174.5 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 CCF43792.1 - 2.9e-28 98.6 0.1 6e-28 97.6 0.1 1.5 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 CCF43792.1 - 5.7e-23 81.1 0.0 8e-21 74.2 0.0 2.7 3 0 0 3 3 3 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 CCF43792.1 - 1.4e-10 40.8 0.1 3.6e-10 39.5 0.1 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme GxGYxYP_N PF16216.5 CCF43792.1 - 0.00061 20.0 0.1 0.0013 19.0 0.1 1.5 1 0 0 1 1 1 1 GxGYxY sequence motif in domain of unknown function N-terminal Biotin_lipoyl_2 PF13533.6 CCF43792.1 - 0.001 18.9 0.0 0.0022 17.8 0.0 1.5 1 0 0 1 1 1 1 Biotin-lipoyl like ATP-grasp_3 PF02655.14 CCF43792.1 - 0.004 17.2 0.0 0.083 12.9 0.0 3.0 3 1 0 3 3 3 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 CCF43792.1 - 0.017 14.6 0.0 0.036 13.6 0.0 1.5 1 1 0 1 1 1 0 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.6 CCF43792.1 - 0.044 13.5 0.0 0.086 12.6 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp PF02222.22 CCF43792.1 - 0.048 13.2 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain Voltage_CLC PF00654.20 CCF43793.1 - 7.3e-48 163.6 6.6 8.7e-48 163.4 6.6 1.1 1 0 0 1 1 1 1 Voltage gated chloride channel DUF2062 PF09835.9 CCF43793.1 - 0.00069 19.5 0.2 0.00069 19.5 0.2 2.0 3 0 0 3 3 3 1 Uncharacterized protein conserved in bacteria (DUF2062) CBS PF00571.28 CCF43793.1 - 0.0049 17.3 0.1 0.023 15.1 0.1 2.1 2 0 0 2 2 2 1 CBS domain BofA PF07441.11 CCF43793.1 - 0.023 14.9 0.2 0.023 14.9 0.2 2.5 3 0 0 3 3 3 0 SigmaK-factor processing regulatory protein BofA LacI PF00356.21 CCF43793.1 - 0.095 12.5 0.3 0.21 11.4 0.3 1.5 1 0 0 1 1 1 0 Bacterial regulatory proteins, lacI family NDUF_B7 PF05676.13 CCF43794.1 - 1.6e-30 104.6 5.4 1.9e-30 104.3 5.4 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Cmc1 PF08583.10 CCF43794.1 - 0.0014 18.6 1.7 0.0016 18.4 1.4 1.3 1 1 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like TauD PF02668.16 CCF43798.1 - 4.5e-16 59.5 0.2 4.9e-16 59.3 0.2 1.0 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family adh_short PF00106.25 CCF43799.1 - 6e-16 58.5 0.1 6.5e-16 58.4 0.1 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF43799.1 - 4.6e-11 42.7 0.1 5.2e-11 42.5 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF43799.1 - 9.9e-09 35.4 0.1 1.2e-08 35.1 0.1 1.0 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 CCF43799.1 - 0.00016 21.6 0.1 0.00019 21.4 0.1 1.1 1 0 0 1 1 1 1 NAD(P)H-binding DFP PF04127.15 CCF43799.1 - 0.0037 17.1 0.1 0.0053 16.6 0.1 1.1 1 0 0 1 1 1 1 DNA / pantothenate metabolism flavoprotein ADH_zinc_N PF00107.26 CCF43801.1 - 6.9e-12 45.5 0.0 1e-11 44.9 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCF43801.1 - 4.6e-05 24.5 0.0 6.8e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 3A PF00803.18 CCF43801.1 - 0.055 12.8 0.0 0.07 12.4 0.0 1.2 1 0 0 1 1 1 0 3A/RNA2 movement protein family Clathrin_propel PF01394.20 CCF43802.1 - 1.6e-38 129.2 0.2 1.5e-08 34.5 0.1 6.6 6 0 0 6 6 6 6 Clathrin propeller repeat Clathrin_H_link PF13838.6 CCF43802.1 - 2.1e-32 110.8 0.7 4.4e-32 109.8 0.7 1.6 1 0 0 1 1 1 1 Clathrin-H-link Clathrin PF00637.20 CCF43802.1 - 5.6e-13 49.0 0.0 5.2e-12 45.8 0.0 2.5 1 1 2 3 3 3 1 Region in Clathrin and VPS Clathrin-link PF09268.10 CCF43802.1 - 0.0033 16.7 0.3 0.0087 15.4 0.3 1.8 1 0 0 1 1 1 1 Clathrin, heavy-chain linker PQQ_2 PF13360.6 CCF43802.1 - 0.032 13.8 0.0 2 8.0 0.1 2.6 2 1 1 3 3 3 0 PQQ-like domain DUF4131 PF13567.6 CCF43804.1 - 0.068 12.8 1.2 0.1 12.3 1.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) RhoGAP PF00620.27 CCF43805.1 - 4.3e-39 133.8 0.0 7.2e-39 133.0 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain Glyco_transf_22 PF03901.17 CCF43806.1 - 1.3e-79 268.4 22.1 1.5e-79 268.2 22.1 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family Aminotran_3 PF00202.21 CCF43807.1 - 1.2e-121 406.2 0.0 1.4e-121 406.0 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Beta_elim_lyase PF01212.21 CCF43807.1 - 0.00024 20.5 0.0 0.00051 19.4 0.0 1.5 1 1 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 CCF43807.1 - 0.13 11.4 0.0 0.26 10.4 0.0 1.4 1 0 0 1 1 1 0 Aminotransferase class I and II Methyltr_RsmB-F PF01189.17 CCF43808.1 - 4.9e-17 62.2 0.0 2.5e-10 40.3 0.0 2.3 2 0 0 2 2 2 2 16S rRNA methyltransferase RsmB/F Band_7 PF01145.25 CCF43809.1 - 4.9e-16 59.3 0.1 4.9e-16 59.3 0.1 3.3 3 2 0 3 3 3 1 SPFH domain / Band 7 family SDH_alpha PF03313.15 CCF43811.1 - 4.5e-06 26.5 0.0 4.8e-06 26.5 0.0 1.0 1 0 0 1 1 1 1 Serine dehydratase alpha chain PAN_4 PF14295.6 CCF43812.1 - 0.002 18.0 7.0 0.043 13.7 0.1 3.0 3 1 0 3 3 3 2 PAN domain PTPLA PF04387.14 CCF43813.1 - 1e-56 191.2 14.3 1.4e-56 190.8 14.3 1.2 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA MFS_1 PF07690.16 CCF43820.1 - 1.1e-35 123.2 72.4 1.5e-35 122.7 69.4 2.6 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 CCF43820.1 - 1.5e-13 50.1 26.4 2e-13 49.7 24.6 1.9 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 CCF43820.1 - 1.3e-11 44.1 32.9 1.5e-11 43.9 16.5 2.5 2 0 0 2 2 2 2 Sugar (and other) transporter TIC20 PF16166.5 CCF43820.1 - 0.091 12.5 4.0 0.32 10.8 0.3 2.5 2 0 0 2 2 2 0 Chloroplast import apparatus Tic20-like Fungal_trans_2 PF11951.8 CCF43821.1 - 1.9e-07 30.3 0.1 5.2e-07 28.8 0.0 1.6 1 1 1 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF43821.1 - 9.4e-07 28.9 10.0 1.9e-06 27.9 10.0 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain LSM PF01423.22 CCF43823.1 - 5.6e-21 74.0 0.5 6.7e-21 73.8 0.5 1.1 1 0 0 1 1 1 1 LSM domain hNIFK_binding PF12196.8 CCF43824.1 - 0.13 11.7 0.1 0.13 11.7 0.1 3.1 3 0 0 3 3 3 0 FHA Ki67 binding domain of hNIFK Methyltransf_23 PF13489.6 CCF43828.1 - 3.3e-18 66.1 0.0 5.1e-18 65.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF43828.1 - 2.2e-09 37.3 0.0 1.1e-08 35.1 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF43828.1 - 3.1e-09 37.4 0.0 8e-09 36.1 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF43828.1 - 1.4e-06 28.9 0.0 2.7e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF43828.1 - 4.8e-06 27.2 0.0 1.9e-05 25.3 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 CCF43828.1 - 0.00011 22.4 0.0 0.00024 21.3 0.0 1.8 1 1 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_4 PF02390.17 CCF43828.1 - 0.0013 18.3 0.0 0.0035 16.8 0.0 1.7 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_2 PF00891.18 CCF43828.1 - 0.0024 17.2 0.0 0.0037 16.6 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain PCMT PF01135.19 CCF43828.1 - 0.006 16.3 0.0 0.024 14.4 0.0 1.9 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 CCF43828.1 - 0.016 14.8 0.0 0.041 13.4 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase small domain Ubie_methyltran PF01209.18 CCF43828.1 - 0.058 12.7 0.0 0.27 10.5 0.0 2.1 2 1 0 2 2 2 0 ubiE/COQ5 methyltransferase family CMAS PF02353.20 CCF43828.1 - 0.18 11.1 0.0 0.35 10.1 0.0 1.4 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Glyco_hydro_cc PF11790.8 CCF43831.1 - 5.8e-21 75.2 0.2 8e-21 74.7 0.2 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core DUF1308 PF07000.11 CCF43832.1 - 0.00032 20.7 0.0 0.00079 19.4 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1308) DUF5614 PF18474.1 CCF43832.1 - 0.006 15.9 0.0 0.011 15.1 0.0 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5614) Peptidase_M43 PF05572.13 CCF43833.1 - 6.7e-16 58.6 0.2 8.6e-16 58.2 0.2 1.2 1 0 0 1 1 1 1 Pregnancy-associated plasma protein-A Reprolysin_5 PF13688.6 CCF43833.1 - 5.5e-06 26.7 0.2 6.8e-06 26.4 0.2 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.6 CCF43833.1 - 1.4e-05 24.8 0.1 1.5e-05 24.7 0.1 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.6 CCF43833.1 - 1.8e-05 25.2 0.0 3.3e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 CCF43833.1 - 0.00028 20.8 0.2 0.00033 20.6 0.2 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M66 PF10462.9 CCF43833.1 - 0.0018 17.3 0.1 0.0027 16.7 0.1 1.3 1 0 0 1 1 1 1 Peptidase M66 Peptidase_M10 PF00413.24 CCF43833.1 - 0.0071 16.2 0.1 0.013 15.4 0.0 1.5 1 1 0 1 1 1 1 Matrixin Peptidase_M54 PF07998.11 CCF43833.1 - 0.016 15.2 0.1 0.028 14.4 0.1 1.3 1 0 0 1 1 1 0 Peptidase family M54 DUF4953 PF16313.5 CCF43833.1 - 0.057 12.6 0.0 0.092 11.9 0.0 1.3 1 0 0 1 1 1 0 Met-zincin Metallopep PF12044.8 CCF43833.1 - 0.15 10.7 1.0 0.18 10.4 0.5 1.4 2 0 0 2 2 2 0 Putative peptidase family Peptidase_M28 PF04389.17 CCF43834.1 - 3.8e-38 131.2 0.0 5.4e-38 130.7 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 CCF43834.1 - 5.5e-09 36.0 0.3 2.9e-08 33.7 0.3 2.0 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 CN_hydrolase PF00795.22 CCF43836.1 - 8.3e-32 110.5 0.0 1.4e-31 109.8 0.0 1.3 1 1 0 1 1 1 1 Carbon-nitrogen hydrolase Fungal_trans PF04082.18 CCF43837.1 - 9.2e-13 47.8 0.0 1.6e-12 47.1 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Glyco_transf_17 PF04724.13 CCF43838.1 - 1.5e-50 172.2 0.2 1.3e-49 169.1 0.2 1.9 1 1 0 1 1 1 1 Glycosyltransferase family 17 HTH_32 PF13565.6 CCF43839.1 - 8.2e-07 29.6 6.6 3.7e-05 24.2 1.4 2.4 1 1 1 2 2 2 2 Homeodomain-like domain HTH_Tnp_Tc3_2 PF01498.18 CCF43839.1 - 0.00036 20.7 0.0 0.0014 18.8 0.0 1.9 1 1 1 2 2 2 1 Transposase HTH_7 PF02796.15 CCF43839.1 - 0.035 14.2 0.6 9.2 6.4 0.1 2.6 2 1 0 2 2 2 0 Helix-turn-helix domain of resolvase HTH_39 PF14090.6 CCF43839.1 - 0.038 13.7 0.0 1 9.2 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_38 PF13936.6 CCF43839.1 - 0.046 13.5 0.0 0.17 11.6 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_23 PF13384.6 CCF43839.1 - 0.077 12.8 0.1 0.18 11.6 0.1 1.6 1 0 0 1 1 1 0 Homeodomain-like domain DUF4796 PF16044.5 CCF43840.1 - 0.025 14.2 0.0 0.039 13.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4796) FYDLN_acid PF09538.10 CCF43840.1 - 0.13 12.9 10.8 0.29 11.8 10.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) NOA36 PF06524.12 CCF43840.1 - 5.6 6.2 5.4 8.7 5.6 5.4 1.2 1 0 0 1 1 1 0 NOA36 protein DnaJ PF00226.31 CCF43841.1 - 7.7e-21 74.0 0.3 1.4e-20 73.2 0.3 1.4 1 0 0 1 1 1 1 DnaJ domain Endonuc-dimeris PF09124.10 CCF43841.1 - 0.23 11.7 2.8 9.7 6.4 0.3 2.5 1 1 0 2 2 2 0 T4 recombination endonuclease VII, dimerisation Aim19 PF10315.9 CCF43842.1 - 0.0018 18.6 0.5 0.012 15.9 0.0 2.0 1 1 1 2 2 2 1 Altered inheritance of mitochondria protein 19 Prp18 PF02840.15 CCF43843.1 - 1.1e-18 67.6 0.0 1.2e-18 67.5 0.0 1.0 1 0 0 1 1 1 1 Prp18 domain RPN7 PF10602.9 CCF43844.1 - 2.3e-21 76.3 0.0 4.8e-21 75.2 0.0 1.6 2 0 0 2 2 2 1 26S proteasome subunit RPN7 PCI PF01399.27 CCF43844.1 - 3.2e-13 50.1 0.0 6.1e-13 49.2 0.0 1.4 1 0 0 1 1 1 1 PCI domain PMT PF02366.18 CCF43845.1 - 2.5e-85 286.0 13.1 2.9e-85 285.8 13.1 1.0 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_2 PF13231.6 CCF43845.1 - 0.00026 21.2 10.7 0.00026 21.2 10.7 2.3 2 1 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase DUF2976 PF11190.8 CCF43845.1 - 0.01 15.7 2.9 0.054 13.3 1.5 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF2976) UQ_con PF00179.26 CCF43847.1 - 1e-49 167.8 0.1 1.1e-49 167.6 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 CCF43847.1 - 5.7e-05 22.8 0.0 6.2e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 CCF43847.1 - 0.0094 16.2 2.5 0.02 15.2 2.5 1.8 1 1 0 1 1 1 1 RWD domain FAD_binding_6 PF00970.24 CCF43848.1 - 9.6e-31 106.1 0.0 1.5e-30 105.5 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 CCF43848.1 - 8.7e-28 97.1 0.0 1.2e-27 96.7 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 CCF43848.1 - 4.6e-05 23.6 0.0 0.007 16.5 0.0 2.2 2 0 0 2 2 2 2 Ferric reductase NAD binding domain G-patch_2 PF12656.7 CCF43849.1 - 1.2e-14 54.1 1.0 1.2e-14 54.1 1.0 2.4 2 0 0 2 2 2 1 G-patch domain Sugar_tr PF00083.24 CCF43850.1 - 2.8e-73 247.3 16.7 3.3e-73 247.1 16.7 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF43850.1 - 1.1e-14 54.2 23.8 1.1e-14 54.2 23.8 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_2 PF13347.6 CCF43850.1 - 6.4e-06 25.0 2.4 6.4e-06 25.0 2.4 2.3 2 0 0 2 2 2 1 MFS/sugar transport protein zf-C2HCIx2C PF10782.9 CCF43851.1 - 0.02 14.8 0.3 0.57 10.1 0.1 2.2 2 0 0 2 2 2 0 Zinc-finger HpcH_HpaI PF03328.14 CCF43852.1 - 3.6e-30 104.7 0.0 4.5e-30 104.4 0.0 1.1 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family DUF836 PF05768.14 CCF43853.1 - 1.2e-13 51.3 0.0 1.4e-13 51.0 0.0 1.1 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Glutaredoxin PF00462.24 CCF43853.1 - 0.00041 20.5 0.0 0.00077 19.6 0.0 1.6 1 0 0 1 1 1 1 Glutaredoxin DUF1223 PF06764.11 CCF43853.1 - 0.14 12.2 0.0 0.21 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1223) Glyco_transf_20 PF00982.21 CCF43854.1 - 6.5e-146 486.7 0.0 9.2e-146 486.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 CCF43854.1 - 1.4e-38 132.3 0.0 2.8e-38 131.4 0.0 1.5 1 0 0 1 1 1 1 Trehalose-phosphatase Pyridoxal_deC PF00282.19 CCF43855.1 - 2e-77 260.4 0.0 2.5e-77 260.2 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.21 CCF43855.1 - 2.4e-05 23.8 0.0 3.4e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 CCF43855.1 - 0.0011 18.0 0.0 0.0016 17.5 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Neuralized PF07177.12 CCF43855.1 - 0.051 13.6 0.0 0.53 10.3 0.0 2.5 3 0 0 3 3 3 0 Neuralized GMC_oxred_N PF00732.19 CCF43856.1 - 4.1e-45 154.4 0.5 5.5e-45 154.0 0.5 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCF43856.1 - 2e-26 93.3 0.6 2.9e-25 89.5 0.0 2.6 2 1 0 2 2 2 1 GMC oxidoreductase FAD_binding_2 PF00890.24 CCF43856.1 - 8.6e-08 31.7 2.9 1.9e-07 30.5 2.9 1.5 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CCF43856.1 - 2.5e-06 26.9 0.2 2.8e-05 23.5 0.1 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 CCF43856.1 - 3.6e-06 26.5 0.1 5.6e-06 25.8 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 CCF43856.1 - 1.2e-05 25.5 0.2 6.3e-05 23.1 0.0 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 CCF43856.1 - 1.4e-05 24.5 0.2 0.00034 20.0 0.2 2.3 2 0 0 2 2 2 1 Thi4 family DAO PF01266.24 CCF43856.1 - 3.9e-05 23.4 2.0 0.041 13.4 0.3 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase HI0933_like PF03486.14 CCF43856.1 - 0.0016 17.2 1.0 0.0064 15.2 0.2 2.0 2 0 0 2 2 2 1 HI0933-like protein FAD_oxidored PF12831.7 CCF43856.1 - 0.003 17.0 1.8 0.0049 16.3 1.8 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase UDPG_MGDP_dh_N PF03721.14 CCF43856.1 - 0.019 14.5 1.3 0.03 13.9 1.3 1.2 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain GIDA PF01134.22 CCF43856.1 - 0.02 14.0 0.2 0.077 12.1 0.1 1.8 2 0 0 2 2 2 0 Glucose inhibited division protein A GDI PF00996.18 CCF43856.1 - 0.034 12.7 0.1 0.049 12.1 0.1 1.1 1 0 0 1 1 1 0 GDP dissociation inhibitor AlaDh_PNT_C PF01262.21 CCF43856.1 - 0.037 13.3 0.0 0.059 12.6 0.0 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.27 CCF43856.1 - 0.05 14.2 0.2 0.11 13.1 0.2 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCF43856.1 - 0.054 12.7 0.0 5 6.3 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 CCF43856.1 - 0.061 13.2 0.1 0.098 12.5 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ThiF PF00899.21 CCF43856.1 - 0.13 11.6 0.0 0.26 10.6 0.0 1.4 1 0 0 1 1 1 0 ThiF family MoaC PF01967.21 CCF43857.1 - 6.9e-13 48.9 0.9 6.9e-13 48.9 0.9 1.6 2 0 0 2 2 2 1 MoaC family zinc_ribbon_10 PF10058.9 CCF43858.1 - 4.5e-20 71.1 0.3 9.1e-20 70.1 0.1 1.6 2 0 0 2 2 2 1 Predicted integral membrane zinc-ribbon metal-binding protein SET PF00856.28 CCF43859.1 - 2.3e-09 37.9 0.0 4e-08 33.8 0.0 2.4 1 1 0 1 1 1 1 SET domain RGI1 PF10843.8 CCF43861.1 - 0.18 11.4 0.0 0.19 11.3 0.0 1.1 1 0 0 1 1 1 0 Respiratory growth induced protein 1 EHN PF06441.12 CCF43862.1 - 4.7e-33 113.8 0.3 7.1e-33 113.2 0.3 1.3 1 0 0 1 1 1 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 CCF43862.1 - 4.4e-10 39.6 0.2 7.8e-10 38.8 0.1 1.5 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCF43862.1 - 0.00096 19.8 0.2 0.0016 19.1 0.2 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family adh_short PF00106.25 CCF43864.1 - 1.9e-28 99.3 0.1 2.8e-28 98.7 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF43864.1 - 4.9e-21 75.4 0.2 7.7e-21 74.7 0.2 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 CCF43864.1 - 0.002 17.6 0.2 0.0027 17.2 0.2 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family AlaDh_PNT_C PF01262.21 CCF43864.1 - 0.01 15.2 0.2 0.022 14.1 0.2 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Eno-Rase_NADH_b PF12242.8 CCF43864.1 - 0.034 13.9 0.9 0.063 13.0 0.2 1.8 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase KR PF08659.10 CCF43864.1 - 0.069 13.1 3.2 3.3 7.6 3.2 2.8 1 1 0 1 1 1 0 KR domain GH131_N PF18271.1 CCF43865.1 - 2.8e-74 250.1 0.0 3.2e-74 249.9 0.0 1.0 1 0 0 1 1 1 1 Glycoside hydrolase 131 catalytic N-terminal domain Pro-kuma_activ PF09286.11 CCF43867.1 - 9.6e-49 165.3 0.2 2.3e-48 164.1 0.1 1.6 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain zf-AN1 PF01428.16 CCF43869.1 - 1e-12 48.0 8.2 1.1e-12 47.8 8.2 1.1 1 0 0 1 1 1 1 AN1-like Zinc finger Transp_Tc5_C PF04236.15 CCF43869.1 - 0.14 12.6 5.6 0.16 12.3 5.6 1.1 1 0 0 1 1 1 0 Tc5 transposase C-terminal domain TPR_10 PF13374.6 CCF43870.1 - 1.4e-32 110.7 0.7 3.6e-14 52.1 0.0 3.0 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 CCF43870.1 - 3.2e-27 94.6 0.0 3.9e-15 55.9 0.0 2.0 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 CCF43870.1 - 2e-15 55.6 0.1 1.7e-05 24.5 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 CCF43870.1 - 3.1e-06 27.2 0.3 0.6 10.6 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 CCF43870.1 - 1.8e-05 24.5 0.1 0.057 13.6 0.0 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 CCF43870.1 - 2.2e-05 24.0 0.0 0.054 13.3 0.0 2.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_4 PF07721.14 CCF43870.1 - 5.3e-05 23.5 0.0 0.2 12.3 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 CCF43870.1 - 0.00045 20.8 0.0 0.031 14.9 0.0 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 CCF43870.1 - 0.0046 17.4 0.0 0.11 13.0 0.0 2.1 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 CCF43870.1 - 0.017 15.9 0.1 2.6 9.1 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat CutA1 PF03091.15 CCF43870.1 - 0.052 13.4 1.6 1.3 8.9 0.2 2.1 1 1 1 2 2 2 0 CutA1 divalent ion tolerance protein TPR_8 PF13181.6 CCF43870.1 - 0.096 12.9 0.1 0.41 11.0 0.0 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat PPR PF01535.20 CCF43870.1 - 0.18 12.1 0.2 4.9 7.6 0.0 2.3 2 0 0 2 2 2 0 PPR repeat FSH1 PF03959.13 CCF43873.1 - 1.5e-29 103.2 0.0 2.9e-28 99.0 0.0 2.0 1 1 0 1 1 1 1 Serine hydrolase (FSH1) DLH PF01738.18 CCF43873.1 - 0.011 15.3 0.0 0.017 14.7 0.0 1.3 1 1 0 1 1 1 0 Dienelactone hydrolase family Abhydrolase_2 PF02230.16 CCF43873.1 - 0.024 14.4 0.0 0.044 13.6 0.0 1.5 1 1 0 1 1 1 0 Phospholipase/Carboxylesterase Abhydrolase_6 PF12697.7 CCF43873.1 - 0.026 15.1 0.8 0.085 13.5 0.3 1.7 1 1 1 2 2 2 0 Alpha/beta hydrolase family TolA_bind_tri PF16331.5 CCF43874.1 - 0.013 15.6 0.3 1.4 9.1 0.2 2.3 2 0 0 2 2 2 0 TolA binding protein trimerisation Laminin_II PF06009.12 CCF43874.1 - 0.065 13.3 0.4 0.11 12.5 0.4 1.4 1 1 0 1 1 1 0 Laminin Domain II XhlA PF10779.9 CCF43874.1 - 0.45 10.7 2.3 1.3 9.3 0.5 2.0 2 0 0 2 2 2 0 Haemolysin XhlA RSN1_7TM PF02714.15 CCF43875.1 - 1.1e-83 280.7 27.8 1.1e-83 280.7 27.8 1.8 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 CCF43875.1 - 2.5e-38 132.0 0.3 3.6e-38 131.5 0.3 1.2 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter RSN1_TM PF13967.6 CCF43875.1 - 6.3e-31 107.3 1.0 6.3e-31 107.3 1.0 3.4 5 0 0 5 5 5 1 Late exocytosis, associated with Golgi transport PHM7_ext PF12621.8 CCF43875.1 - 1.1e-30 105.7 0.1 3.2e-30 104.1 0.1 1.8 2 0 0 2 2 2 1 Extracellular tail, of 10TM putative phosphate transporter kleA_kleC PF17383.2 CCF43875.1 - 0.094 13.0 0.7 0.27 11.6 0.7 1.8 1 0 0 1 1 1 0 Uncharacterized KorC regulated protein A Prominin PF05478.11 CCF43877.1 - 0.43 8.5 1.8 0.58 8.0 1.8 1.1 1 0 0 1 1 1 0 Prominin DZR PF12773.7 CCF43878.1 - 0.13 12.3 2.8 0.36 10.9 2.8 1.7 1 0 0 1 1 1 0 Double zinc ribbon zinc_ribbon_2 PF13240.6 CCF43878.1 - 0.2 11.4 3.1 0.59 9.9 3.1 1.8 1 0 0 1 1 1 0 zinc-ribbon domain LicD PF04991.13 CCF43879.1 - 2.5e-21 76.9 4.5 8.5e-16 58.8 0.7 2.2 1 1 1 2 2 2 2 LicD family NUDIX PF00293.28 CCF43880.1 - 6e-07 29.6 0.7 1e-06 28.8 0.7 1.6 1 1 0 1 1 1 1 NUDIX domain CFEM PF05730.11 CCF43881.1 - 0.00013 22.0 2.9 0.00013 22.0 2.9 2.7 2 0 0 2 2 2 1 CFEM domain COX8 PF02285.15 CCF43881.1 - 2.3 8.2 4.7 1.5 8.8 0.8 2.8 2 0 0 2 2 2 0 Cytochrome oxidase c subunit VIII OMPdecase PF00215.24 CCF43883.1 - 9.4e-104 345.9 0.0 1.1e-103 345.7 0.0 1.0 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family polyprenyl_synt PF00348.17 CCF43884.1 - 6.3e-40 136.9 0.8 7.6e-40 136.6 0.8 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase Condensation PF00668.20 CCF43885.1 - 5.9e-40 137.3 0.0 7.1e-30 104.1 0.0 2.3 2 0 0 2 2 2 2 Condensation domain PP-binding PF00550.25 CCF43885.1 - 2.3e-16 59.9 3.2 4.7e-08 33.3 0.3 2.9 2 0 0 2 2 2 2 Phosphopantetheine attachment site DUF3337 PF11816.8 CCF43887.1 - 5.6e-55 185.8 0.0 1.2e-54 184.8 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3337) WW PF00397.26 CCF43888.1 - 1.6e-10 40.9 0.1 4.3e-10 39.5 0.1 1.8 1 0 0 1 1 1 1 WW domain PhoD PF09423.10 CCF43888.1 - 0.038 13.0 0.2 0.062 12.3 0.2 1.2 1 0 0 1 1 1 0 PhoD-like phosphatase DUF3989 PF13150.6 CCF43889.1 - 2.1 8.2 4.8 0.22 11.3 0.5 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3989) Fungal_trans PF04082.18 CCF43890.1 - 9.2e-15 54.4 0.0 1.4e-14 53.8 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF43890.1 - 6.7e-05 22.9 4.9 0.00011 22.3 4.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF932 PF06067.11 CCF43890.1 - 0.2 11.4 0.0 0.35 10.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF932) Glyco_hydro_15 PF00723.21 CCF43891.1 - 2.2e-84 283.8 0.0 2.7e-84 283.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 CBM_20 PF00686.19 CCF43891.1 - 1.8e-21 75.8 0.0 4.5e-21 74.6 0.0 1.7 1 0 0 1 1 1 1 Starch binding domain p450 PF00067.22 CCF43892.1 - 2.4e-50 171.7 0.0 3.3e-50 171.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Methyltransf_23 PF13489.6 CCF43893.1 - 5.2e-19 68.7 0.0 8e-19 68.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF43893.1 - 2.4e-09 37.8 0.0 8.2e-09 36.1 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF43893.1 - 9.2e-07 29.5 0.0 7.7e-06 26.6 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF43893.1 - 2.9e-06 27.1 0.0 6.6e-05 22.7 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF43893.1 - 4.4e-05 24.1 0.0 0.00011 22.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CCF43893.1 - 0.00095 18.8 0.0 0.0022 17.6 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase small domain CMAS PF02353.20 CCF43893.1 - 0.0013 18.1 0.0 0.003 16.9 0.0 1.6 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_4 PF02390.17 CCF43893.1 - 0.0055 16.2 0.0 0.022 14.2 0.0 2.0 2 0 0 2 2 2 1 Putative methyltransferase FtsJ PF01728.19 CCF43893.1 - 0.057 13.5 0.0 0.088 12.9 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase PrmA PF06325.13 CCF43893.1 - 0.15 11.4 0.0 0.23 10.8 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Ubie_methyltran PF01209.18 CCF43893.1 - 0.18 11.1 0.0 0.95 8.8 0.0 2.0 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family Met_10 PF02475.16 CCF43893.1 - 0.18 11.5 0.0 0.32 10.7 0.0 1.4 1 0 0 1 1 1 0 Met-10+ like-protein Cnn_1N PF07989.11 CCF43894.1 - 1.1e-26 92.7 3.9 1.1e-26 92.7 3.9 19.1 4 3 11 15 15 15 2 Centrosomin N-terminal motif 1 PACT_coil_coil PF10495.9 CCF43894.1 - 4.8e-25 87.9 1.2 4.8e-25 87.9 1.2 5.6 5 0 0 5 5 5 1 Pericentrin-AKAP-450 domain of centrosomal targeting protein Spc7 PF08317.11 CCF43894.1 - 0.00071 18.6 226.1 0.0039 16.1 32.5 10.3 1 1 9 10 10 10 7 Spc7 kinetochore protein DUF4200 PF13863.6 CCF43894.1 - 0.00098 19.5 11.7 0.00098 19.5 11.7 14.1 2 2 11 13 13 13 2 Domain of unknown function (DUF4200) DUF1664 PF07889.12 CCF43894.1 - 0.0015 18.6 7.6 0.0015 18.6 7.6 12.7 3 2 14 17 17 17 6 Protein of unknown function (DUF1664) MscS_porin PF12795.7 CCF43894.1 - 0.0063 16.1 13.3 0.0063 16.1 13.3 10.3 1 1 6 9 9 9 3 Mechanosensitive ion channel porin domain TPR_MLP1_2 PF07926.12 CCF43894.1 - 0.011 15.9 16.3 0.011 15.9 16.3 13.4 5 2 6 12 12 12 0 TPR/MLP1/MLP2-like protein Halo_GVPC PF05465.13 CCF43894.1 - 4.7 7.6 12.7 13 6.1 0.2 5.4 4 0 0 4 4 4 0 Halobacterial gas vesicle protein C (GVPC) repeat Peptidase_C14 PF00656.22 CCF43895.1 - 6.1e-52 177.0 0.0 8.1e-52 176.6 0.0 1.1 1 0 0 1 1 1 1 Caspase domain Raptor_N PF14538.6 CCF43895.1 - 0.21 11.5 0.0 0.6 10.0 0.0 1.7 2 0 0 2 2 2 0 Raptor N-terminal CASPase like domain Nha1_C PF08619.10 CCF43898.1 - 1.1e-132 443.6 31.5 1.3e-132 443.3 31.5 1.0 1 0 0 1 1 1 1 Alkali metal cation/H+ antiporter Nha1 C terminus Na_H_Exchanger PF00999.21 CCF43898.1 - 8.5e-06 24.8 0.9 1e-05 24.5 0.9 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Mso1_C PF14477.6 CCF43898.1 - 1.1 9.7 6.0 17 5.9 0.3 3.2 3 0 0 3 3 3 0 Membrane-polarising domain of Mso1 Glyco_hydro_3_C PF01915.22 CCF43899.1 - 1e-51 175.8 0.0 1.4e-51 175.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 CCF43899.1 - 5.6e-25 87.3 0.2 1.7e-24 85.7 0.1 1.9 2 0 0 2 2 2 1 Fibronectin type III-like domain Glyco_hydro_3 PF00933.21 CCF43899.1 - 5.2e-14 52.4 0.0 8.7e-14 51.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Pyr_redox_2 PF07992.14 CCF43900.1 - 4.7e-42 144.2 0.0 7.7e-39 133.7 0.0 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCF43900.1 - 4.1e-14 52.9 0.0 2.3e-11 44.1 0.0 3.0 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCF43900.1 - 7.4e-06 25.4 0.0 0.0071 15.6 0.0 2.6 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCF43900.1 - 0.011 16.0 0.0 8.8 6.6 0.0 2.8 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Methyltransf_23 PF13489.6 CCF43901.1 - 1e-14 54.7 0.0 1.4e-14 54.3 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF43901.1 - 1e-05 26.1 0.0 2.8e-05 24.8 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF43901.1 - 1.5e-05 24.9 0.0 0.00014 21.7 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF43901.1 - 0.0024 18.5 0.0 0.0047 17.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF43901.1 - 0.0038 17.9 0.0 0.033 14.9 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 CCF43901.1 - 0.14 12.3 0.0 0.28 11.3 0.0 1.5 2 0 0 2 2 2 0 FtsJ-like methyltransferase Methyltransf_2 PF00891.18 CCF43901.1 - 0.16 11.3 0.0 1.5 8.0 0.0 2.2 2 1 0 2 2 2 0 O-methyltransferase domain Phage_holin_3_6 PF07332.11 CCF43902.1 - 0.003 17.6 4.0 0.0048 16.9 0.4 2.6 1 1 1 2 2 2 1 Putative Actinobacterial Holin-X, holin superfamily III Cyt_bd_oxida_II PF02322.15 CCF43902.1 - 0.035 13.5 3.9 0.051 12.9 3.9 1.2 1 0 0 1 1 1 0 Cytochrome bd terminal oxidase subunit II DUF4418 PF14387.6 CCF43902.1 - 0.044 14.0 4.7 0.12 12.6 4.6 1.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4418) 7tm_7 PF08395.12 CCF43902.1 - 0.086 12.0 7.7 0.13 11.5 7.7 1.2 1 0 0 1 1 1 0 7tm Chemosensory receptor Wzy_C_2 PF11846.8 CCF43902.1 - 0.15 12.0 2.2 0.26 11.2 0.1 2.0 2 0 0 2 2 2 0 Virulence factor membrane-bound polymerase, C-terminal DUF4131 PF13567.6 CCF43902.1 - 5.5 6.6 6.0 5 6.7 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Acyl_transf_1 PF00698.21 CCF43903.1 - 2.6e-24 86.3 0.0 3.5e-24 85.9 0.0 1.2 1 0 0 1 1 1 1 Acyl transferase domain PS-DH PF14765.6 CCF43903.1 - 0.0025 17.1 0.0 0.0055 16.0 0.0 1.5 1 0 0 1 1 1 1 Polyketide synthase dehydratase SAT PF16073.5 CCF43903.1 - 0.027 14.2 0.2 1.5 8.5 0.1 3.0 2 1 0 2 2 2 0 Starter unit:ACP transacylase in aflatoxin biosynthesis WD40 PF00400.32 CCF43905.1 - 0.0084 16.9 0.1 0.033 15.0 0.0 1.9 2 0 0 2 2 2 1 WD domain, G-beta repeat DNA_topoisoIV PF00521.20 CCF43907.1 - 5e-124 414.4 1.2 1.9e-123 412.5 0.1 2.2 2 0 0 2 2 2 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 CCF43907.1 - 2e-47 160.6 2.1 2e-47 160.6 2.1 2.7 3 0 0 3 3 3 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.25 CCF43907.1 - 1.5e-25 89.7 3.0 3.3e-25 88.6 3.0 1.6 1 0 0 1 1 1 1 DNA gyrase B HATPase_c PF02518.26 CCF43907.1 - 2.4e-13 50.5 0.0 6.3e-13 49.2 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 CCF43907.1 - 1.2e-06 28.7 0.0 5.8e-06 26.5 0.0 2.3 1 0 0 1 1 1 1 Toprim domain Reticulon PF02453.17 CCF43908.1 - 6.6e-34 117.1 2.9 8.7e-34 116.7 2.9 1.2 1 0 0 1 1 1 1 Reticulon FUSC_2 PF13515.6 CCF43908.1 - 0.19 11.9 4.8 1.5 8.9 0.9 2.2 2 0 0 2 2 2 0 Fusaric acid resistance protein-like DUF3328 PF11807.8 CCF43909.1 - 2.2e-09 37.4 0.0 2.4e-09 37.3 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Pox_A14 PF05767.12 CCF43909.1 - 0.0027 17.8 0.1 0.0036 17.4 0.1 1.2 1 0 0 1 1 1 1 Poxvirus virion envelope protein A14 S-AdoMet_synt_C PF02773.16 CCF43910.1 - 7.3e-47 158.8 0.4 7.3e-47 158.8 0.4 1.9 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.16 CCF43910.1 - 5.7e-45 152.4 0.0 1.1e-44 151.5 0.0 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.20 CCF43910.1 - 4e-43 146.1 0.3 9.6e-43 144.9 0.0 1.8 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, N-terminal domain AdoMet_Synthase PF01941.19 CCF43910.1 - 0.077 11.8 0.5 0.58 8.9 0.1 2.1 1 1 0 2 2 2 0 S-adenosylmethionine synthetase (AdoMet synthetase) Dr_adhesin PF12393.8 CCF43911.1 - 0.13 12.6 1.2 0.46 10.8 1.2 2.0 1 0 0 1 1 1 0 Dr family adhesin Fungal_trans PF04082.18 CCF43913.1 - 9.7e-21 74.0 0.3 1.5e-20 73.3 0.3 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Na_Ca_ex PF01699.24 CCF43915.1 - 1.3e-24 86.8 26.7 7.8e-24 84.4 12.9 2.8 2 1 1 3 3 3 2 Sodium/calcium exchanger protein Syntaxin-5_N PF11416.8 CCF43915.1 - 0.17 11.2 0.3 0.29 10.4 0.3 1.4 1 0 0 1 1 1 0 Syntaxin-5 N-terminal, Sly1p-binding domain UDPGT PF00201.18 CCF43916.1 - 4.8e-05 22.3 0.0 7.8e-05 21.6 0.0 1.2 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase ATG_C PF09333.11 CCF43916.1 - 0.00031 21.0 0.0 0.00075 19.8 0.0 1.6 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain Glyco_tran_28_C PF04101.16 CCF43916.1 - 0.038 14.0 0.0 0.081 12.9 0.0 1.5 1 0 0 1 1 1 0 Glycosyltransferase family 28 C-terminal domain Ribosomal_L29 PF00831.23 CCF43917.1 - 1.4e-18 66.6 1.2 1.4e-18 66.6 1.2 2.1 2 0 0 2 2 2 1 Ribosomal L29 protein Vps54_N PF10475.9 CCF43917.1 - 0.13 11.5 1.7 0.15 11.3 1.7 1.1 1 0 0 1 1 1 0 Vacuolar-sorting protein 54, of GARP complex V-SNARE_C PF12352.8 CCF43918.1 - 2.7e-12 46.8 0.5 2.7e-12 46.8 0.5 3.1 4 0 0 4 4 4 1 Snare region anchored in the vesicle membrane C-terminus STAT_alpha PF01017.20 CCF43918.1 - 0.0073 16.2 4.7 0.16 11.9 2.3 2.5 2 1 1 3 3 3 1 STAT protein, all-alpha domain Spc7 PF08317.11 CCF43918.1 - 0.14 11.0 8.9 0.12 11.2 7.8 1.5 1 1 0 1 1 1 0 Spc7 kinetochore protein Syntaxin-6_N PF09177.11 CCF43918.1 - 0.47 11.0 8.7 1.1 9.8 5.5 2.6 1 1 0 2 2 2 0 Syntaxin 6, N-terminal Fib_alpha PF08702.10 CCF43918.1 - 5.1 7.3 7.9 1.6 8.9 2.9 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family FUSC PF04632.12 CCF43918.1 - 5.6 5.4 11.4 4.3 5.8 9.9 1.4 1 1 0 1 1 1 0 Fusaric acid resistance protein family DUF1451 PF07295.11 CCF43918.1 - 7.8 6.5 7.0 12 5.9 2.3 2.3 1 1 1 2 2 2 0 Zinc-ribbon containing domain ATP-synt_10 PF05176.14 CCF43919.1 - 8.7e-77 257.8 0.0 1.1e-76 257.5 0.0 1.1 1 0 0 1 1 1 1 ATP10 protein 2-oxoacid_dh PF00198.23 CCF43920.1 - 1.7e-73 246.9 0.1 3.4e-73 245.9 0.0 1.5 2 0 0 2 2 2 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 CCF43920.1 - 3.2e-18 65.3 0.0 5.7e-18 64.5 0.0 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 CCF43920.1 - 2.7e-13 50.0 0.2 6.3e-13 48.8 0.2 1.7 1 0 0 1 1 1 1 e3 binding domain Biotin_lipoyl_2 PF13533.6 CCF43920.1 - 0.32 10.8 0.0 0.32 10.8 0.0 2.1 3 0 0 3 3 3 0 Biotin-lipoyl like SKI PF01202.22 CCF43921.1 - 1.3e-10 41.6 0.0 1.8e-10 41.2 0.0 1.2 1 0 0 1 1 1 1 Shikimate kinase AAA_33 PF13671.6 CCF43921.1 - 4.8e-09 36.5 0.0 6.8e-09 36.0 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CCF43921.1 - 2.3e-08 34.6 0.0 8e-08 32.9 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.6 CCF43921.1 - 1.7e-05 25.2 0.0 4.9e-05 23.8 0.0 1.8 1 1 0 1 1 1 1 AAA domain Rad17 PF03215.15 CCF43921.1 - 1.8e-05 24.7 0.0 3.4e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain Cytidylate_kin PF02224.18 CCF43921.1 - 1.9e-05 24.5 0.0 4.6e-05 23.2 0.0 1.6 2 0 0 2 2 2 1 Cytidylate kinase AAA PF00004.29 CCF43921.1 - 6.3e-05 23.4 0.2 0.00021 21.7 0.0 1.9 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CCF43921.1 - 0.00021 21.7 0.0 0.00026 21.4 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 CCF43921.1 - 0.00081 19.7 0.0 0.0014 18.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain CoaE PF01121.20 CCF43921.1 - 0.0011 18.6 0.0 0.017 14.8 0.0 2.3 2 0 0 2 2 2 1 Dephospho-CoA kinase PRK PF00485.18 CCF43921.1 - 0.0012 18.6 0.0 0.0033 17.2 0.0 1.7 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family NACHT PF05729.12 CCF43921.1 - 0.0015 18.4 0.0 0.0027 17.6 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA_28 PF13521.6 CCF43921.1 - 0.0022 18.2 0.0 0.01 16.1 0.0 1.9 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 CCF43921.1 - 0.0025 18.2 0.0 0.0051 17.2 0.0 1.5 1 0 0 1 1 1 1 RNA helicase AAA_5 PF07728.14 CCF43921.1 - 0.003 17.6 0.0 0.0057 16.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) dNK PF01712.19 CCF43921.1 - 0.0032 17.3 0.0 0.17 11.7 0.0 2.1 2 0 0 2 2 2 1 Deoxynucleoside kinase AAA_7 PF12775.7 CCF43921.1 - 0.011 15.3 0.0 0.028 14.0 0.0 1.7 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_30 PF13604.6 CCF43921.1 - 0.011 15.5 0.0 0.023 14.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain Thymidylate_kin PF02223.17 CCF43921.1 - 0.013 15.2 0.0 4.8 6.8 0.0 2.2 2 0 0 2 2 2 0 Thymidylate kinase Cytidylate_kin2 PF13189.6 CCF43921.1 - 0.018 15.2 0.0 0.078 13.1 0.0 1.9 2 0 0 2 2 2 0 Cytidylate kinase-like family ABC_tran PF00005.27 CCF43921.1 - 0.018 15.6 0.0 0.032 14.8 0.0 1.5 1 0 0 1 1 1 0 ABC transporter Mg_chelatase PF01078.21 CCF43921.1 - 0.018 14.4 0.1 0.063 12.7 0.0 1.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI ATPase_2 PF01637.18 CCF43921.1 - 0.023 14.6 0.0 0.042 13.8 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea T2SSE PF00437.20 CCF43921.1 - 0.026 13.6 0.0 0.052 12.6 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein TsaE PF02367.17 CCF43921.1 - 0.027 14.5 0.0 0.044 13.8 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE APS_kinase PF01583.20 CCF43921.1 - 0.03 14.2 0.0 0.043 13.7 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_14 PF13173.6 CCF43921.1 - 0.032 14.3 0.0 0.083 12.9 0.0 1.7 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 CCF43921.1 - 0.045 13.6 0.0 0.1 12.5 0.0 1.5 1 0 0 1 1 1 0 NTPase DNA_pol3_delta2 PF13177.6 CCF43921.1 - 0.06 13.1 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 DNA polymerase III, delta subunit AAA_23 PF13476.6 CCF43921.1 - 0.072 13.6 0.0 0.12 12.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.12 CCF43921.1 - 0.077 12.7 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_19 PF13245.6 CCF43921.1 - 0.1 12.9 0.1 0.33 11.3 0.0 1.7 2 0 0 2 2 2 0 AAA domain PhoH PF02562.16 CCF43921.1 - 0.12 11.8 0.0 0.21 11.0 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein YIF1 PF03878.15 CCF43922.1 - 4.4e-101 337.4 1.0 5e-101 337.2 1.0 1.0 1 0 0 1 1 1 1 YIF1 Yip1 PF04893.17 CCF43922.1 - 0.2 11.3 14.3 0.084 12.6 11.0 1.9 1 1 1 2 2 2 0 Yip1 domain GCFC PF07842.12 CCF43924.1 - 4.2e-69 233.2 2.5 5.6e-69 232.8 2.5 1.1 1 0 0 1 1 1 1 GC-rich sequence DNA-binding factor-like protein DUF2938 PF11158.8 CCF43924.1 - 0.072 12.6 0.1 0.14 11.6 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2938) UCH PF00443.29 CCF43925.1 - 9.3e-38 130.2 0.1 4.4e-33 114.8 0.0 2.3 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CCF43925.1 - 6e-09 35.9 2.8 6.8e-08 32.5 2.8 2.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Hen1_L PF12623.7 CCF43925.1 - 0.076 12.1 0.0 7.3 5.6 0.0 2.3 2 0 0 2 2 2 0 RNA repair, ligase-Pnkp-associating, region of Hen1 DUF4071 PF13281.6 CCF43925.1 - 0.098 11.7 0.0 0.17 10.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4071) Kelch_4 PF13418.6 CCF43926.1 - 4.4e-23 81.0 7.7 2.6e-06 27.3 0.0 6.2 5 1 0 5 5 5 4 Galactose oxidase, central domain Kelch_3 PF13415.6 CCF43926.1 - 8.4e-21 73.8 6.7 2e-07 31.1 0.0 5.1 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_5 PF13854.6 CCF43926.1 - 5.8e-18 64.5 2.0 2.3e-07 30.7 0.0 5.4 6 0 0 6 6 6 3 Kelch motif Kelch_2 PF07646.15 CCF43926.1 - 2.2e-14 52.8 4.7 0.0033 17.3 0.0 6.2 6 1 0 6 6 6 4 Kelch motif Kelch_6 PF13964.6 CCF43926.1 - 5.8e-13 48.6 1.1 0.00021 21.5 0.1 5.0 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 CCF43926.1 - 2.3e-10 39.9 0.3 0.0053 16.3 0.0 4.8 4 1 0 4 4 4 4 Kelch motif DENN PF02141.21 CCF43931.1 - 3.4e-58 196.7 0.0 5.5e-58 196.0 0.0 1.3 1 0 0 1 1 1 1 DENN (AEX-3) domain dDENN PF03455.19 CCF43931.1 - 3.9e-15 55.6 1.5 9.2e-15 54.4 1.5 1.7 1 0 0 1 1 1 1 dDENN domain uDENN PF03456.18 CCF43931.1 - 2e-13 50.8 0.0 4.7e-13 49.7 0.0 1.7 1 0 0 1 1 1 1 uDENN domain C1_1 PF00130.22 CCF43931.1 - 0.00075 19.3 8.2 0.0017 18.2 8.2 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.16 CCF43931.1 - 0.0013 19.0 7.6 0.0027 18.0 7.6 1.5 1 0 0 1 1 1 1 C1 domain Zf_RING PF16744.5 CCF43931.1 - 0.062 13.4 3.3 0.13 12.4 3.3 1.5 1 0 0 1 1 1 0 KIAA1045 RING finger PHD PF00628.29 CCF43931.1 - 0.1 12.5 6.9 0.25 11.3 6.9 1.7 1 0 0 1 1 1 0 PHD-finger zf-HC5HC2H_2 PF13832.6 CCF43931.1 - 0.18 12.0 3.5 0.38 10.9 3.5 1.4 1 0 0 1 1 1 0 PHD-zinc-finger like domain DUF4592 PF15262.6 CCF43931.1 - 4 8.1 11.8 0.63 10.7 1.2 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4592) SNAP PF14938.6 CCF43932.1 - 2.3e-115 384.9 15.8 2.6e-115 384.7 15.8 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.6 CCF43932.1 - 2.1e-07 31.1 11.2 0.00043 20.5 0.4 3.5 2 1 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 CCF43932.1 - 1.8e-05 24.5 14.1 0.57 10.4 0.2 6.1 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.6 CCF43932.1 - 5.5e-05 23.1 10.7 0.46 10.8 0.4 5.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 CCF43932.1 - 0.0016 18.3 9.3 2.8 8.2 0.3 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 CCF43932.1 - 0.037 14.5 0.3 0.037 14.5 0.3 4.2 3 2 1 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 CCF43932.1 - 0.2 12.4 14.7 45 5.0 0.0 5.8 5 1 0 5 5 5 0 Tetratricopeptide repeat PPR_long PF17177.4 CCF43932.1 - 0.26 10.6 4.3 0.12 11.7 0.4 2.2 2 1 1 3 3 3 0 Pentacotripeptide-repeat region of PRORP TPR_16 PF13432.6 CCF43932.1 - 0.46 11.2 19.8 0.93 10.2 0.0 4.8 3 2 2 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.28 CCF43932.1 - 0.46 10.4 17.6 0.48 10.3 0.3 5.2 6 1 0 6 6 6 0 Tetratricopeptide repeat TPR_9 PF13371.6 CCF43932.1 - 0.77 9.9 7.6 1.3 9.2 0.6 3.2 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_3 PF07720.12 CCF43932.1 - 6.4 6.9 9.1 6.1 6.9 0.8 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat HemY_N PF07219.13 CCF43932.1 - 7.8 6.8 6.7 2.3 8.4 0.1 3.0 1 1 2 3 3 3 0 HemY protein N-terminus Glu-tRNAGln PF02686.15 CCF43933.1 - 3.7e-10 40.0 0.0 1.2e-09 38.3 0.0 1.8 1 1 0 1 1 1 1 Glu-tRNAGln amidotransferase C subunit DUF726 PF05277.12 CCF43934.1 - 6.4e-132 439.6 5.3 7.7e-132 439.4 5.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF726) Methyltransf_23 PF13489.6 CCF43935.1 - 1.6e-13 50.8 0.0 2.6e-13 50.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF43935.1 - 2.5e-08 34.5 0.0 1.7e-07 31.8 0.0 2.3 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF43935.1 - 2.4e-05 25.0 0.4 0.00037 21.2 0.1 2.7 2 2 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF43935.1 - 2.5e-05 24.1 0.0 0.0029 17.4 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF43935.1 - 2.8e-05 24.7 0.0 6.2e-05 23.6 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 CCF43935.1 - 0.00067 19.0 0.0 0.00089 18.6 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_4 PF02390.17 CCF43935.1 - 0.003 17.1 0.0 0.0062 16.0 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase FtsJ PF01728.19 CCF43935.1 - 0.0033 17.6 0.0 0.0047 17.0 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase MTS PF05175.14 CCF43935.1 - 0.0095 15.5 0.0 0.019 14.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain CMAS PF02353.20 CCF43935.1 - 0.019 14.2 0.0 0.028 13.7 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase PrmA PF06325.13 CCF43935.1 - 0.042 13.2 0.0 0.065 12.6 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_16 PF10294.9 CCF43935.1 - 0.053 13.2 0.0 0.072 12.8 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase Ubie_methyltran PF01209.18 CCF43935.1 - 0.13 11.6 0.0 0.24 10.7 0.0 1.4 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family GidB PF02527.15 CCF43935.1 - 0.14 11.5 0.0 0.93 8.8 0.0 1.9 2 0 0 2 2 2 0 rRNA small subunit methyltransferase G POT1PC PF16686.5 CCF43936.1 - 1.1e-47 161.8 0.3 2.3e-47 160.8 0.3 1.6 1 0 0 1 1 1 1 ssDNA-binding domain of telomere protection protein POT1 PF02765.17 CCF43936.1 - 7.7e-13 48.5 0.0 2e-12 47.2 0.0 1.7 1 1 0 1 1 1 1 Telomeric single stranded DNA binding POT1/CDC13 REPA_OB_2 PF16900.5 CCF43936.1 - 0.023 14.6 0.0 0.12 12.3 0.0 2.2 2 0 0 2 2 2 0 Replication protein A OB domain DivIVA PF05103.13 CCF43936.1 - 0.27 11.3 5.7 0.49 10.5 5.7 1.3 1 0 0 1 1 1 0 DivIVA protein MCM_bind PF09739.9 CCF43936.1 - 0.96 7.8 5.1 1.5 7.2 5.1 1.2 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Borrelia_P83 PF05262.11 CCF43936.1 - 1.6 7.1 11.6 2.4 6.6 11.6 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein FmdA_AmdA PF03069.15 CCF43937.1 - 0.11 11.3 0.1 0.2 10.5 0.1 1.4 1 0 0 1 1 1 0 Acetamidase/Formamidase family DUF3484 PF11983.8 CCF43937.1 - 3.1 9.0 6.3 2.2 9.5 0.2 2.8 2 0 0 2 2 2 0 Membrane-attachment and polymerisation-promoting switch DUF3128 PF11326.8 CCF43937.1 - 5.3 7.5 14.7 33 4.9 0.4 3.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3128) adh_short PF00106.25 CCF43938.1 - 2.6e-08 33.6 0.1 3.3e-08 33.2 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF43938.1 - 0.00017 21.2 0.1 0.00021 21.0 0.1 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Peptidase_M19 PF01244.21 CCF43939.1 - 0.0079 15.4 0.3 0.011 14.9 0.3 1.2 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) DUF3966 PF13110.6 CCF43939.1 - 0.073 13.0 0.2 1.2 9.1 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3966) TetR_C_27 PF17935.1 CCF43939.1 - 0.075 13.1 0.2 0.22 11.6 0.0 1.8 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Med9 PF07544.13 CCF43939.1 - 0.089 12.9 0.1 0.49 10.5 0.0 2.1 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 NOA36 PF06524.12 CCF43939.1 - 7 5.9 12.0 7.8 5.7 10.9 1.6 1 1 0 1 1 1 0 NOA36 protein HET PF06985.11 CCF43940.1 - 2.7e-18 66.7 0.4 1e-17 64.9 0.0 1.8 1 1 1 2 2 2 1 Heterokaryon incompatibility protein (HET) MFS_1 PF07690.16 CCF43941.1 - 5.3e-13 48.6 22.5 6.9e-13 48.2 22.5 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sulfatase PF00884.23 CCF43942.1 - 5.4e-66 223.1 0.7 7.5e-66 222.6 0.7 1.2 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 CCF43942.1 - 0.0053 16.4 1.2 1.3 8.5 0.1 2.2 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase DUF4976 PF16347.5 CCF43942.1 - 0.018 15.3 0.0 0.047 14.0 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4976) Glyco_hydro_92 PF07971.12 CCF43943.1 - 5.8e-145 483.7 0.0 7.2e-145 483.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 CCF43943.1 - 8.5e-60 202.6 0.8 1.3e-59 202.0 0.8 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain ATP-synt_J PF04911.12 CCF43944.1 - 0.1 12.2 0.2 0.18 11.4 0.2 1.4 1 0 0 1 1 1 0 ATP synthase j chain SR-25 PF10500.9 CCF43946.1 - 0.14 11.7 8.4 0.16 11.5 8.4 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein IMUP PF15761.5 CCF43946.1 - 0.31 11.7 6.5 0.4 11.4 6.5 1.1 1 0 0 1 1 1 0 Immortalisation up-regulated protein Peptidase_S10 PF00450.22 CCF43947.1 - 3.3e-113 379.3 0.1 3.9e-113 379.0 0.1 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Med2 PF11214.8 CCF43948.1 - 0.038 14.1 3.5 0.054 13.6 3.5 1.2 1 0 0 1 1 1 0 Mediator complex subunit 2 eIF-3_zeta PF05091.12 CCF43948.1 - 0.047 12.7 0.8 0.055 12.5 0.8 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) MRPL52 PF18699.1 CCF43948.1 - 0.18 12.0 4.0 0.28 11.4 4.0 1.2 1 0 0 1 1 1 0 Mitoribosomal protein mL52 TatD_DNase PF01026.21 CCF43949.1 - 7.5e-28 97.6 0.0 1.2e-27 97.0 0.0 1.2 1 0 0 1 1 1 1 TatD related DNase UbiA PF01040.18 CCF43952.1 - 2.4e-41 141.7 15.8 3.1e-41 141.3 15.8 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family Ribosom_S12_S23 PF00164.25 CCF43953.1 - 4.2e-22 77.9 0.0 4.6e-22 77.8 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S12/S23 ABM PF03992.16 CCF43954.1 - 2.3e-05 24.4 0.0 0.025 14.7 0.0 2.4 2 1 0 2 2 2 2 Antibiotic biosynthesis monooxygenase DUF3764 PF12594.8 CCF43954.1 - 0.16 12.0 0.0 0.29 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3764) PLA2_B PF01735.18 CCF43957.1 - 1.8e-27 95.9 0.0 4e-27 94.8 0.0 1.5 1 1 0 1 1 1 1 Lysophospholipase catalytic domain Ribonucleas_3_3 PF14622.6 CCF43958.1 - 0.0001 22.5 0.0 0.19 11.9 0.0 2.3 2 0 0 2 2 2 2 Ribonuclease-III-like dsrm PF00035.26 CCF43958.1 - 0.0029 18.3 0.0 0.0059 17.3 0.0 1.5 1 0 0 1 1 1 1 Double-stranded RNA binding motif Ribonuclease_3 PF00636.26 CCF43958.1 - 0.013 16.1 0.0 0.09 13.4 0.0 2.3 1 1 0 1 1 1 0 Ribonuclease III domain Vac_ImportDeg PF09783.9 CCF43960.1 - 2e-65 219.5 0.3 3.9e-51 173.1 0.5 2.1 2 0 0 2 2 2 2 Vacuolar import and degradation protein RgpF PF05045.12 CCF43961.1 - 0.0079 15.0 0.1 0.13 11.0 0.0 2.0 2 0 0 2 2 2 2 Rhamnan synthesis protein F MFS_1 PF07690.16 CCF43963.1 - 2.8e-05 23.2 22.0 0.00029 19.9 13.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 CCF43963.1 - 0.00096 18.1 6.8 0.0012 17.8 6.8 1.1 1 0 0 1 1 1 1 MFS_1 like family Promethin PF16015.5 CCF43963.1 - 0.01 15.7 2.6 0.029 14.3 2.6 1.7 1 0 0 1 1 1 0 Promethin Abhydrolase_3 PF07859.13 CCF43966.1 - 1.9e-08 34.5 0.0 3.2e-08 33.7 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold RVT_2 PF07727.14 CCF43967.1 - 2.3e-09 37.3 0.0 3.8e-09 36.6 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 CCF43967.1 - 2.7e-07 30.8 0.0 6.7e-07 29.5 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Sec66 PF09802.9 CCF43967.1 - 0.057 13.0 0.2 0.32 10.6 0.0 2.0 2 0 0 2 2 2 0 Preprotein translocase subunit Sec66 5_nucleotid_C PF02872.18 CCF43968.1 - 7.2e-35 120.5 0.5 1.5e-34 119.5 0.5 1.5 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 CCF43968.1 - 2.1e-08 34.9 4.0 5.7e-08 33.5 1.2 2.3 1 1 1 2 2 2 1 Calcineurin-like phosphoesterase Glyco_hydro_62 PF03664.13 CCF43968.1 - 0.082 12.2 0.0 0.18 11.1 0.0 1.5 1 0 0 1 1 1 0 Glycosyl hydrolase family 62 Cu-oxidase_2 PF07731.14 CCF43969.1 - 1.7e-33 115.2 0.4 1.7e-33 115.2 0.4 1.6 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase PF00394.22 CCF43969.1 - 4.6e-06 26.8 0.1 6.4e-05 23.1 0.0 2.1 2 0 0 2 2 2 1 Multicopper oxidase Transp_cyt_pur PF02133.15 CCF43971.1 - 2.4e-19 69.4 1.0 2.8e-19 69.2 1.0 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Fungal_trans PF04082.18 CCF43972.1 - 2.6e-11 43.1 0.1 4.1e-11 42.4 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain UbiD PF01977.16 CCF43973.1 - 1.1e-123 413.2 0.0 1.2e-123 413.0 0.0 1.0 1 0 0 1 1 1 1 3-octaprenyl-4-hydroxybenzoate carboxy-lyase CHZ PF09649.10 CCF43974.1 - 5.8e-19 67.3 1.3 5.8e-19 67.3 1.3 2.0 2 1 0 2 2 2 1 Histone chaperone domain CHZ GP24_25 PF17388.2 CCF43974.1 - 0.0091 16.0 0.4 0.0098 15.9 0.4 1.1 1 0 0 1 1 1 1 Tail assembly gene products 24 & 25 GCIP PF13324.6 CCF43974.1 - 5 6.6 6.0 5 6.7 6.0 1.0 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting Zip PF02535.22 CCF43976.1 - 4e-62 210.4 0.2 4.7e-62 210.1 0.2 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter DUF4728 PF15860.5 CCF43976.1 - 0.04 14.6 1.4 0.43 11.3 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4728) SIR2 PF02146.17 CCF43977.1 - 3.3e-23 82.5 0.0 5.1e-22 78.6 0.0 2.0 1 1 0 1 1 1 1 Sir2 family PhnA_Zn_Ribbon PF08274.12 CCF43977.1 - 0.11 12.4 1.0 0.21 11.6 1.0 1.4 1 0 0 1 1 1 0 PhnA Zinc-Ribbon MFS_1 PF07690.16 CCF43978.1 - 2.7e-15 56.2 18.6 2.7e-15 56.2 18.6 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily Glyco_transf_52 PF07922.11 CCF43978.1 - 0.0008 18.8 0.0 0.0011 18.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 52 Phosphodiest PF01663.22 CCF43979.1 - 0.00077 19.1 0.0 0.0021 17.7 0.0 1.6 2 0 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase FAR1 PF03101.15 CCF43979.1 - 0.0013 19.4 0.0 0.0026 18.4 0.0 1.5 1 0 0 1 1 1 1 FAR1 DNA-binding domain Golgin_A5 PF09787.9 CCF43979.1 - 0.016 14.7 1.7 0.023 14.2 1.7 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 CCDC158 PF15921.5 CCF43979.1 - 0.05 11.4 0.3 0.066 11.0 0.3 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 158 SKA2 PF16740.5 CCF43979.1 - 0.12 12.2 1.9 1.4 8.8 0.8 2.1 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 HIP1_clath_bdg PF16515.5 CCF43979.1 - 0.34 11.6 6.9 0.15 12.7 3.7 1.8 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Spc7 PF08317.11 CCF43979.1 - 0.6 8.9 6.2 0.52 9.2 4.6 1.6 1 1 1 2 2 2 0 Spc7 kinetochore protein Peptidase_M28 PF04389.17 CCF43980.1 - 1.8e-18 67.0 0.0 2.5e-18 66.5 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 adh_short PF00106.25 CCF43981.1 - 8.4e-39 133.1 0.1 1e-38 132.8 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF43981.1 - 1.5e-27 96.7 0.7 1.8e-27 96.4 0.7 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF43981.1 - 1.3e-07 31.7 0.1 1.7e-07 31.3 0.1 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 CCF43981.1 - 1.7e-07 31.3 0.6 1.7e-07 31.3 0.6 1.7 2 0 0 2 2 2 1 NAD(P)H-binding Epimerase PF01370.21 CCF43981.1 - 2.7e-05 23.8 0.2 3.4e-05 23.4 0.2 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family ADH_zinc_N PF00107.26 CCF43981.1 - 0.0071 16.3 0.3 0.036 14.0 0.1 2.1 2 0 0 2 2 2 1 Zinc-binding dehydrogenase DFP PF04127.15 CCF43981.1 - 0.013 15.4 0.0 0.019 14.8 0.0 1.3 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein NmrA PF05368.13 CCF43981.1 - 0.021 14.4 0.2 0.032 13.8 0.2 1.2 1 0 0 1 1 1 0 NmrA-like family RmlD_sub_bind PF04321.17 CCF43981.1 - 0.12 11.4 0.1 0.24 10.5 0.1 1.5 1 1 0 1 1 1 0 RmlD substrate binding domain M20_dimer PF07687.14 CCF43982.1 - 1.6e-20 73.0 0.1 2.5e-20 72.4 0.1 1.3 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M20 PF01546.28 CCF43982.1 - 2.1e-09 37.4 0.0 3.2e-09 36.8 0.0 1.4 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 PAH PF02671.21 CCF43983.1 - 3.4e-05 23.9 0.0 8.6e-05 22.6 0.0 1.7 1 1 0 1 1 1 1 Paired amphipathic helix repeat HopW1-1 PF15457.6 CCF43983.1 - 0.048 12.9 0.1 0.059 12.6 0.1 1.1 1 0 0 1 1 1 0 Type III T3SS secreted effector HopW1-1/HopPmaA GCIP PF13324.6 CCF43983.1 - 0.088 12.4 0.0 0.11 12.0 0.0 1.1 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting HATPase_c PF02518.26 CCF43984.1 - 4.1e-20 72.4 0.1 8.3e-20 71.4 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CCF43984.1 - 7.6e-18 64.7 0.0 7.3e-17 61.5 0.0 2.3 2 0 0 2 2 2 1 Response regulator receiver domain HisKA PF00512.25 CCF43984.1 - 1.4e-09 37.8 0.0 3.9e-09 36.4 0.0 1.8 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain Cullin PF00888.22 CCF43985.1 - 3.1e-195 650.4 8.1 4.2e-195 650.0 8.1 1.2 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 CCF43985.1 - 1.3e-26 92.4 4.6 5.4e-26 90.4 4.6 2.2 1 0 0 1 1 1 1 Cullin protein neddylation domain WAC_Acf1_DNA_bd PF10537.9 CCF43985.1 - 0.021 15.3 2.6 0.047 14.2 0.9 2.4 2 0 0 2 2 2 0 ATP-utilising chromatin assembly and remodelling N-terminal Lipoprotein_15 PF03640.15 CCF43986.1 - 0.036 13.6 1.0 5.6 6.6 0.1 2.6 1 1 1 2 2 2 0 Secreted repeat of unknown function DUF5357 PF17310.2 CCF43987.1 - 0.15 10.6 0.3 0.22 10.0 0.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5357) YqzE PF14038.6 CCF43988.1 - 3 7.9 5.0 0.72 9.9 0.1 2.2 2 0 0 2 2 2 0 YqzE-like protein OPT PF03169.15 CCF43989.1 - 1.5e-106 357.5 11.0 1.8e-106 357.2 11.0 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Sugar_tr PF00083.24 CCF43990.1 - 4.1e-38 131.4 13.0 4.6e-38 131.2 13.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF43990.1 - 8.2e-06 25.0 19.3 1e-05 24.6 19.3 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Trep_Strep PF09605.10 CCF43990.1 - 0.01 15.8 2.0 0.01 15.8 2.0 2.6 1 1 1 2 2 2 0 Hypothetical bacterial integral membrane protein (Trep_Strep) FUSC PF04632.12 CCF43990.1 - 1.4 7.4 7.8 0.38 9.2 0.3 2.1 2 0 0 2 2 2 0 Fusaric acid resistance protein family DUF3792 PF12670.7 CCF43990.1 - 1.4 9.1 16.1 3.7 7.8 10.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3792) tRNA-synt_1c PF00749.21 CCF43992.1 - 1e-67 228.3 0.0 1.3e-67 227.9 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 CCF43992.1 - 4.5e-32 111.3 0.1 6.5e-31 107.5 0.0 2.5 3 0 0 3 3 3 1 tRNA synthetases class I (E and Q), anti-codon binding domain ADK PF00406.22 CCF43993.1 - 2e-08 34.5 0.0 2.5e-08 34.2 0.0 1.2 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 CCF43993.1 - 3.4e-06 27.5 0.0 5.4e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 CCF43993.1 - 0.0045 16.7 0.1 0.0077 15.9 0.0 1.4 2 0 0 2 2 2 1 Thymidylate kinase MFS_1 PF07690.16 CCF43994.1 - 1.2e-05 24.5 7.4 1.5e-05 24.1 7.4 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily PseudoU_synth_1 PF01416.20 CCF43995.1 - 9.9e-31 106.4 0.0 8.8e-30 103.4 0.0 2.3 2 0 0 2 2 2 1 tRNA pseudouridine synthase SAND PF01342.21 CCF43995.1 - 0.13 12.0 0.6 0.26 11.0 0.6 1.4 1 0 0 1 1 1 0 SAND domain PIG-H PF10181.9 CCF43996.1 - 1.1e-26 92.5 0.1 1.7e-26 91.9 0.1 1.3 1 0 0 1 1 1 1 GPI-GlcNAc transferase complex, PIG-H component DUF359 PF04019.12 CCF43996.1 - 0.063 12.9 0.0 0.098 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF359) MutS_V PF00488.21 CCF43996.1 - 0.21 11.6 0.0 0.32 11.0 0.0 1.1 1 0 0 1 1 1 0 MutS domain V MFS_1 PF07690.16 CCF43997.1 - 2.2e-41 142.0 47.1 6.5e-41 140.4 47.1 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 CCF43997.1 - 1.9e-11 43.2 10.2 1.9e-11 43.2 10.2 1.5 1 1 1 2 2 2 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.20 CCF43997.1 - 0.005 15.2 2.3 0.005 15.2 2.3 2.8 2 1 1 3 3 3 1 Organic Anion Transporter Polypeptide (OATP) family FSH1 PF03959.13 CCF43998.1 - 2.4e-30 105.8 0.0 3.2e-30 105.4 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) ADH_zinc_N PF00107.26 CCF43999.1 - 1.6e-08 34.6 0.0 3.3e-08 33.6 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCF43999.1 - 6.9e-08 33.6 0.0 1.7e-07 32.4 0.0 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCF43999.1 - 1.2e-07 31.5 0.0 2.6e-07 30.5 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain FAM184 PF15665.5 CCF44000.1 - 0.0037 17.1 1.9 0.0045 16.8 1.9 1.0 1 0 0 1 1 1 1 Family with sequence similarity 184, A and B Uso1_p115_C PF04871.13 CCF44000.1 - 0.065 13.6 2.4 0.081 13.3 2.4 1.1 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region Podoplanin PF05808.11 CCF44001.1 - 0.00027 21.1 1.6 0.00047 20.3 1.6 1.3 1 0 0 1 1 1 1 Podoplanin MGC-24 PF05283.11 CCF44001.1 - 0.0046 17.4 3.2 0.0089 16.5 3.2 1.5 1 0 0 1 1 1 1 Multi-glycosylated core protein 24 (MGC-24), sialomucin Glycophorin_A PF01102.18 CCF44001.1 - 0.065 13.5 0.1 0.17 12.2 0.1 1.7 1 0 0 1 1 1 0 Glycophorin A KGG PF10685.9 CCF44002.1 - 1.8e-24 85.2 20.2 8.4e-11 41.8 1.2 3.1 3 0 0 3 3 3 3 Stress-induced bacterial acidophilic repeat motif DDE_1 PF03184.19 CCF44003.1 - 7.4e-15 55.0 0.0 8.7e-15 54.8 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Cnd2 PF05786.14 CCF44006.1 - 5.8e-46 157.6 0.5 5.9e-46 157.5 0.5 1.0 1 0 0 1 1 1 1 Condensin complex subunit 2 Gag_p15 PF08723.10 CCF44006.1 - 0.024 14.9 0.0 0.027 14.7 0.0 1.2 1 0 0 1 1 1 0 Gag protein p15 Peptidase_S8 PF00082.22 CCF44007.1 - 0.00014 21.3 1.2 0.0002 20.7 1.2 1.2 1 0 0 1 1 1 1 Subtilase family NmrA PF05368.13 CCF44008.1 - 6.6e-36 124.0 0.0 1.1e-35 123.3 0.0 1.3 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CCF44008.1 - 1.3e-10 41.5 0.0 1.8e-10 41.0 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding TrkA_N PF02254.18 CCF44008.1 - 1.9e-05 24.9 0.1 3.7e-05 24.0 0.1 1.4 1 0 0 1 1 1 1 TrkA-N domain 3Beta_HSD PF01073.19 CCF44008.1 - 0.00032 19.8 0.0 0.00044 19.3 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 CCF44008.1 - 0.062 12.7 0.0 0.089 12.2 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Hjc PF01870.18 CCF44008.1 - 0.18 11.8 0.0 0.56 10.2 0.0 1.8 2 0 0 2 2 2 0 Archaeal holliday junction resolvase (hjc) SET PF00856.28 CCF44010.1 - 7e-07 29.8 0.0 1.4e-06 28.8 0.0 1.5 1 0 0 1 1 1 1 SET domain COesterase PF00135.28 CCF44011.1 - 1.9e-89 300.9 0.0 2.4e-89 300.6 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CCF44011.1 - 7e-08 32.6 0.1 1e-06 28.8 0.1 2.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold NTP_transf_3 PF12804.7 CCF44011.1 - 0.026 14.9 0.3 0.047 14.1 0.3 1.4 1 0 0 1 1 1 0 MobA-like NTP transferase domain Ras PF00071.22 CCF44012.1 - 1.4e-31 109.3 0.1 1.8e-31 108.9 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCF44012.1 - 3.9e-24 85.2 0.1 7.6e-24 84.2 0.1 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCF44012.1 - 1.3e-06 28.0 0.0 1.7e-06 27.6 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 CCF44012.1 - 0.00022 20.7 0.1 0.00029 20.3 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region DLIC PF05783.11 CCF44012.1 - 0.0018 17.2 0.2 0.17 10.7 0.0 2.1 1 1 1 2 2 2 2 Dynein light intermediate chain (DLIC) SR-25 PF10500.9 CCF44013.1 - 0.0095 15.6 10.5 0.013 15.1 10.5 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein IMUP PF15761.5 CCF44013.1 - 5.2 7.8 11.6 11 6.7 11.6 1.5 1 1 0 1 1 1 0 Immortalisation up-regulated protein GCV_H PF01597.19 CCF44014.1 - 1.2e-35 122.0 1.8 1.5e-35 121.7 1.8 1.1 1 0 0 1 1 1 1 Glycine cleavage H-protein Biotin_lipoyl PF00364.22 CCF44014.1 - 0.031 14.1 0.8 0.05 13.4 0.2 1.7 2 0 0 2 2 2 0 Biotin-requiring enzyme RnfC_N PF13375.6 CCF44014.1 - 0.04 13.9 0.2 0.064 13.2 0.2 1.4 1 0 0 1 1 1 0 RnfC Barrel sandwich hybrid domain Porphobil_deam PF01379.20 CCF44015.1 - 2.8e-76 255.6 0.0 8.8e-76 254.0 0.0 1.7 2 0 0 2 2 2 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.15 CCF44015.1 - 3.2e-17 62.7 0.1 6e-17 61.8 0.1 1.5 1 0 0 1 1 1 1 Porphobilinogen deaminase, C-terminal domain AAA PF00004.29 CCF44016.1 - 1.4e-07 32.0 0.0 5.5e-07 30.1 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) HDV_ag PF01517.18 CCF44016.1 - 0.0016 18.2 4.7 0.0036 17.1 4.7 1.5 1 1 0 1 1 1 1 Hepatitis delta virus delta antigen TniB PF05621.11 CCF44016.1 - 0.071 12.5 0.0 0.19 11.1 0.0 1.7 1 0 0 1 1 1 0 Bacterial TniB protein TPD PF14811.6 CCF44016.1 - 0.9 9.4 4.2 0.93 9.4 1.4 2.3 3 0 0 3 3 3 0 Protein of unknown function TPD sequence-motif Dynein_attach_N PF15867.5 CCF44016.1 - 2.4 8.2 7.4 0.76 9.8 0.6 2.5 2 0 0 2 2 2 0 Dynein attachment factor N-terminus bVLRF1 PF18826.1 CCF44017.1 - 4.2e-63 211.7 0.1 5.9e-63 211.2 0.1 1.2 1 0 0 1 1 1 1 bacteroidetes VLRF1 release factor Ank_5 PF13857.6 CCF44017.1 - 1.1e-07 32.0 0.0 2.3e-07 30.9 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) zf-C2H2_jaz PF12171.8 CCF44017.1 - 0.056 13.8 0.5 0.1 12.9 0.5 1.4 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding Ank PF00023.30 CCF44017.1 - 0.059 13.8 0.6 0.19 12.2 0.5 2.0 2 0 0 2 2 2 0 Ankyrin repeat Na_H_Exchanger PF00999.21 CCF44020.1 - 1.1e-74 251.6 25.3 1.3e-74 251.3 25.3 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Nha1_C PF08619.10 CCF44020.1 - 1.1e-13 51.2 3.8 1.4e-13 50.9 3.8 1.0 1 0 0 1 1 1 1 Alkali metal cation/H+ antiporter Nha1 C terminus NEXCaM_BD PF16644.5 CCF44022.1 - 0.15 12.4 0.3 0.2 11.9 0.3 1.2 1 0 0 1 1 1 0 Regulatory region of Na+/H+ exchanger NHE binds to calmodulin Band_7 PF01145.25 CCF44024.1 - 1.1e-27 97.2 2.7 1.6e-27 96.7 2.7 1.2 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 CCF44024.1 - 0.015 15.0 0.2 0.023 14.4 0.2 1.3 1 0 0 1 1 1 0 SPFH domain-Band 7 family 2OG-FeII_Oxy_3 PF13640.6 CCF44025.1 - 2.1e-06 28.5 0.1 3.9e-06 27.7 0.1 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Peptidase_M24 PF00557.24 CCF44026.1 - 6.1e-42 143.7 0.0 9.5e-42 143.1 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N PF01321.18 CCF44026.1 - 0.00018 22.2 0.1 0.0087 16.7 0.0 2.4 2 0 0 2 2 2 1 Creatinase/Prolidase N-terminal domain Sugar_tr PF00083.24 CCF44027.1 - 1.5e-35 123.0 26.0 8.7e-34 117.2 26.0 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF44027.1 - 2.5e-26 92.5 40.0 1.2e-14 54.0 9.9 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 CCF44027.1 - 6.7e-05 21.6 22.2 0.0023 16.6 7.0 2.4 2 0 0 2 2 2 2 MFS/sugar transport protein DUF2231 PF09990.9 CCF44027.1 - 0.13 12.8 3.3 0.52 10.8 3.3 2.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2231) OPT PF03169.15 CCF44028.1 - 4.5e-120 402.1 39.4 5.2e-120 401.9 39.4 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Phage_holin_5_2 PF16079.5 CCF44028.1 - 0.011 16.1 0.9 0.011 16.1 0.9 3.7 4 0 0 4 4 4 0 Phage holin family Hol44, in holin superfamily V CrgA PF06781.12 CCF44028.1 - 0.41 10.7 5.7 0.32 11.1 0.2 3.0 3 0 0 3 3 3 0 Cell division protein CrgA DUF3093 PF11292.8 CCF44028.1 - 3 8.1 6.1 8.7 6.6 6.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3093) Arylesterase PF01731.20 CCF44029.1 - 0.0011 19.1 0.0 0.0025 18.0 0.0 1.6 1 0 0 1 1 1 1 Arylesterase SGL PF08450.12 CCF44029.1 - 0.0088 15.6 0.0 0.016 14.8 0.0 1.4 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Tim17 PF02466.19 CCF44030.1 - 2.4e-14 53.6 1.5 4.3e-14 52.8 1.5 1.4 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family DUF5518 PF17647.1 CCF44030.1 - 0.038 14.1 4.5 3.1 8.0 0.1 2.2 1 1 1 2 2 2 0 Family of unknown function (DUF5518) Oxidored_FMN PF00724.20 CCF44031.1 - 9.5e-79 265.1 0.0 1.3e-78 264.7 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Ribosomal_S8e PF01201.22 CCF44032.1 - 5.7e-45 152.8 4.5 1.1e-44 151.9 4.5 1.5 1 1 0 1 1 1 1 Ribosomal protein S8e Bud13 PF09736.9 CCF44032.1 - 0.54 10.6 15.2 0.22 11.9 12.2 1.7 2 0 0 2 2 2 0 Pre-mRNA-splicing factor of RES complex Pannexin_like PF12534.8 CCF44032.1 - 4.8 6.2 6.5 6.8 5.7 6.5 1.1 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 Ribosomal_L21p PF00829.21 CCF44033.1 - 4.6e-11 42.9 0.0 6.4e-11 42.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal prokaryotic L21 protein Pkinase PF00069.25 CCF44034.1 - 8.3e-45 153.2 0.0 1.2e-44 152.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF44034.1 - 5.1e-19 68.6 0.0 7.8e-19 68.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CCF44034.1 - 0.0013 18.7 0.0 1 9.3 0.0 2.5 1 1 1 2 2 2 2 Phosphotransferase enzyme family RIO1 PF01163.22 CCF44034.1 - 0.16 11.6 0.1 0.38 10.3 0.1 1.7 1 1 0 1 1 1 0 RIO1 family Ribosomal_60s PF00428.19 CCF44035.1 - 2.6e-27 95.2 6.1 3e-27 95.0 6.1 1.0 1 0 0 1 1 1 1 60s Acidic ribosomal protein UBA_6 PF18039.1 CCF44035.1 - 0.14 12.1 1.1 0.17 11.8 0.2 1.6 2 0 0 2 2 2 0 UBA-like domain SPT2 PF08243.11 CCF44036.1 - 8.5e-09 35.9 13.1 8.5e-09 35.9 13.1 3.2 3 1 1 4 4 4 2 SPT2 chromatin protein DUF2457 PF10446.9 CCF44037.1 - 0.00089 18.5 7.5 0.0016 17.7 7.5 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2457) Menin PF05053.13 CCF44037.1 - 0.021 13.2 2.7 0.029 12.8 2.7 1.1 1 0 0 1 1 1 0 Menin CDC45 PF02724.14 CCF44037.1 - 0.026 12.8 5.2 0.035 12.4 5.2 1.1 1 0 0 1 1 1 0 CDC45-like protein eIF-3c_N PF05470.12 CCF44037.1 - 0.051 11.9 1.5 0.053 11.8 1.5 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus RRN3 PF05327.11 CCF44037.1 - 0.072 11.6 3.1 0.1 11.1 3.1 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Sigma70_ner PF04546.13 CCF44037.1 - 0.11 12.4 2.4 0.2 11.5 2.4 1.4 1 0 0 1 1 1 0 Sigma-70, non-essential region FAM176 PF14851.6 CCF44037.1 - 0.17 11.5 5.9 0.075 12.7 3.0 1.9 2 0 0 2 2 2 0 FAM176 family Nop14 PF04147.12 CCF44037.1 - 0.3 9.2 8.2 0.42 8.8 8.2 1.1 1 0 0 1 1 1 0 Nop14-like family CobT PF06213.12 CCF44037.1 - 0.36 10.2 7.1 0.58 9.5 7.1 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT PI3K_1B_p101 PF10486.9 CCF44037.1 - 0.37 8.5 6.2 0.5 8.1 6.2 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit TRAP_alpha PF03896.16 CCF44037.1 - 0.54 9.4 3.7 0.88 8.7 3.7 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Peptidase_S64 PF08192.11 CCF44037.1 - 0.61 8.5 4.0 0.73 8.3 4.0 1.1 1 0 0 1 1 1 0 Peptidase family S64 GREB1 PF15782.5 CCF44037.1 - 5.5 4.0 5.2 6.8 3.7 5.2 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Pkinase PF00069.25 CCF44038.1 - 1.3e-63 214.9 0.0 1.7e-63 214.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF44038.1 - 5.1e-31 107.9 0.0 7.1e-31 107.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF44038.1 - 0.036 13.4 0.0 0.061 12.6 0.0 1.3 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 CCF44038.1 - 0.075 12.9 0.0 0.26 11.2 0.0 1.7 1 1 0 2 2 2 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 CCF44038.1 - 0.13 11.1 0.0 0.19 10.6 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Gti1_Pac2 PF09729.9 CCF44039.1 - 3.1e-41 141.4 12.0 1.7e-36 126.0 0.2 3.1 2 2 1 3 3 3 2 Gti1/Pac2 family Mus7 PF09462.10 CCF44040.1 - 2.4e-24 86.2 0.3 3.1e-24 85.8 0.3 1.1 1 0 0 1 1 1 1 Mus7/MMS22 family ADH_zinc_N_2 PF13602.6 CCF44041.1 - 6.7e-15 56.3 0.0 2.1e-14 54.7 0.0 1.9 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 CCF44041.1 - 6.7e-12 45.5 0.0 1.5e-11 44.4 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AAA PF00004.29 CCF44042.1 - 1e-38 132.8 0.0 1.8e-38 132.0 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CCF44042.1 - 7.9e-06 26.2 0.3 0.00087 19.6 0.1 2.7 2 1 1 3 3 2 1 AAA domain RuvB_N PF05496.12 CCF44042.1 - 3.5e-05 23.6 0.0 6.7e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 CCF44042.1 - 0.00025 21.5 0.3 0.0062 16.9 0.1 2.4 1 1 1 2 2 2 1 AAA ATPase domain TIP49 PF06068.13 CCF44042.1 - 0.00037 19.8 0.0 0.00097 18.4 0.0 1.6 1 0 0 1 1 1 1 TIP49 P-loop domain DUF815 PF05673.13 CCF44042.1 - 0.00074 18.7 0.0 0.0013 18.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_2 PF07724.14 CCF44042.1 - 0.0013 18.9 0.0 0.0032 17.6 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.17 CCF44042.1 - 0.0015 18.3 0.0 0.0028 17.4 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein Mg_chelatase PF01078.21 CCF44042.1 - 0.0015 17.9 0.2 0.0067 15.8 0.1 2.1 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 CCF44042.1 - 0.0021 18.1 0.1 0.0089 16.0 0.1 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 CCF44042.1 - 0.013 15.5 0.0 0.026 14.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 CCF44042.1 - 0.015 15.6 0.0 0.044 14.1 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 CCF44042.1 - 0.017 15.3 0.0 0.033 14.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 CCF44042.1 - 0.021 15.1 0.0 0.38 11.0 0.1 2.3 2 0 0 2 2 2 0 AAA domain AAA_11 PF13086.6 CCF44042.1 - 0.027 14.2 0.0 0.14 11.9 0.0 2.0 2 1 0 2 2 2 0 AAA domain AAA_25 PF13481.6 CCF44042.1 - 0.029 14.0 0.0 0.11 12.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 CCF44042.1 - 0.033 14.7 0.0 0.09 13.3 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 CCF44042.1 - 0.052 13.3 0.0 0.13 11.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.9 CCF44042.1 - 0.071 12.3 0.9 0.97 8.6 0.0 2.5 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2075) ATPase PF06745.13 CCF44042.1 - 0.086 12.2 0.5 2.5 7.4 0.0 2.9 2 1 1 3 3 3 0 KaiC AAA_7 PF12775.7 CCF44042.1 - 0.099 12.2 0.0 0.2 11.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region NACHT PF05729.12 CCF44042.1 - 0.11 12.5 0.0 0.26 11.2 0.0 1.7 1 0 0 1 1 1 0 NACHT domain PhoH PF02562.16 CCF44042.1 - 0.11 11.9 0.1 0.29 10.5 0.0 1.6 2 0 0 2 2 2 0 PhoH-like protein Sigma54_activat PF00158.26 CCF44042.1 - 0.16 11.6 0.0 0.37 10.5 0.0 1.7 1 1 0 1 1 1 0 Sigma-54 interaction domain TniB PF05621.11 CCF44042.1 - 0.17 11.3 0.0 4.1 6.8 0.0 2.2 1 1 1 2 2 2 0 Bacterial TniB protein PAN_1 PF00024.26 CCF44043.1 - 0.0002 21.3 0.0 0.00028 20.8 0.0 1.2 1 0 0 1 1 1 1 PAN domain PAN_4 PF14295.6 CCF44043.1 - 0.0014 18.5 0.9 0.0021 18.0 0.9 1.3 1 0 0 1 1 1 1 PAN domain Oxysterol_BP PF01237.18 CCF44044.1 - 2.5e-21 76.0 0.0 2.9e-21 75.7 0.0 1.0 1 0 0 1 1 1 1 Oxysterol-binding protein HA2 PF04408.23 CCF44045.1 - 1.8e-26 92.5 0.0 3.2e-26 91.7 0.0 1.4 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 CCF44045.1 - 2.6e-11 43.9 0.0 8.6e-11 42.2 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 CCF44045.1 - 3.3e-11 43.4 0.0 6.9e-11 42.4 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold YL1 PF05764.13 CCF44045.1 - 5.6 7.0 4.8 9.2 6.3 4.8 1.2 1 0 0 1 1 1 0 YL1 nuclear protein Saf_2TM PF18303.1 CCF44046.1 - 0.00018 21.1 1.1 0.0023 17.6 0.2 2.1 1 1 1 2 2 2 1 SAVED-fused 2TM effector domain DUF2306 PF10067.9 CCF44046.1 - 0.0029 17.8 3.3 0.0029 17.8 3.3 1.6 1 1 1 2 2 2 1 Predicted membrane protein (DUF2306) Cytochrom_B561 PF03188.16 CCF44046.1 - 0.014 15.6 2.3 0.014 15.6 2.3 1.9 1 1 1 2 2 2 0 Eukaryotic cytochrome b561 Pox_P21 PF05313.12 CCF44046.1 - 0.19 11.3 0.2 0.19 11.3 0.2 1.5 2 0 0 2 2 2 0 Poxvirus P21 membrane protein Ni_hydr_CYTB PF01292.20 CCF44046.1 - 0.21 11.1 6.4 3.1 7.4 1.7 2.1 1 1 1 2 2 2 0 Prokaryotic cytochrome b561 MWFE PF15879.5 CCF44046.1 - 0.26 11.5 1.8 9.6 6.5 0.0 2.9 3 0 0 3 3 3 0 NADH-ubiquinone oxidoreductase MWFE subunit PspC PF04024.12 CCF44046.1 - 1.7 8.6 6.4 0.39 10.6 2.8 1.8 2 0 0 2 2 2 0 PspC domain DUF3139 PF11337.8 CCF44046.1 - 1.7 9.4 3.3 2.2 9.0 0.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3139) PAF-AH_p_II PF03403.13 CCF44049.1 - 2e-41 141.8 0.0 1.5e-36 125.7 0.0 2.1 2 0 0 2 2 2 2 Platelet-activating factor acetylhydrolase, isoform II Chlorophyllase2 PF12740.7 CCF44049.1 - 0.00017 20.6 0.0 0.00036 19.5 0.0 1.5 2 0 0 2 2 2 1 Chlorophyllase enzyme Hydrolase_4 PF12146.8 CCF44049.1 - 0.00037 19.8 0.1 0.045 13.0 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Chlorophyllase PF07224.11 CCF44049.1 - 0.023 13.7 0.0 0.05 12.6 0.0 1.5 1 0 0 1 1 1 0 Chlorophyllase Peptidase_M43 PF05572.13 CCF44051.1 - 3.5e-08 33.5 0.1 1.1e-07 31.9 0.0 1.8 2 0 0 2 2 2 1 Pregnancy-associated plasma protein-A Reprolysin_5 PF13688.6 CCF44051.1 - 0.00024 21.3 0.0 0.0004 20.6 0.0 1.4 1 1 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 CCF44051.1 - 0.00076 20.0 0.0 0.0011 19.4 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 CCF44051.1 - 0.0012 18.7 0.3 0.0022 17.9 0.3 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.24 CCF44051.1 - 0.01 15.7 0.1 0.016 15.1 0.1 1.4 1 0 0 1 1 1 0 Matrixin Reprolysin_4 PF13583.6 CCF44051.1 - 0.012 15.3 0.5 0.021 14.4 0.5 1.5 1 1 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M66 PF10462.9 CCF44051.1 - 0.02 13.8 3.1 0.031 13.2 3.1 1.2 1 0 0 1 1 1 0 Peptidase M66 DUF4953 PF16313.5 CCF44051.1 - 0.27 10.4 1.0 0.41 9.8 1.0 1.2 1 0 0 1 1 1 0 Met-zincin Peptidase_M57 PF12388.8 CCF44051.1 - 2 8.0 5.6 1.8 8.1 1.5 2.2 1 1 1 2 2 2 0 Dual-action HEIGH metallo-peptidase NAD_binding_1 PF00175.21 CCF44052.1 - 3.5e-23 82.3 0.0 7.3e-23 81.3 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 CCF44052.1 - 4.1e-18 65.6 0.0 2.4e-08 34.2 0.0 2.3 2 0 0 2 2 2 2 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 CCF44052.1 - 0.0049 17.0 0.0 3.6 7.7 0.0 2.5 2 0 0 2 2 2 2 Ferric reductase NAD binding domain STE3 PF02076.15 CCF44053.1 - 1.3e-44 152.6 8.1 1.5e-44 152.4 8.1 1.0 1 0 0 1 1 1 1 Pheromone A receptor ketoacyl-synt PF00109.26 CCF44055.1 - 8.6e-73 245.0 0.0 1.6e-72 244.1 0.0 1.4 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 CCF44055.1 - 2.2e-23 82.5 0.1 8.4e-23 80.6 0.0 1.8 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.23 CCF44055.1 - 5.7e-07 29.2 0.0 1.1e-06 28.3 0.0 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain ACP_syn_III PF08545.10 CCF44055.1 - 0.033 14.0 0.2 0.033 14.0 0.2 1.8 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III gag_pre-integrs PF13976.6 CCF44056.1 - 0.00016 21.5 1.0 0.00054 19.8 0.4 2.2 2 0 0 2 2 2 1 GAG-pre-integrase domain DUF4800 PF16057.5 CCF44057.1 - 0.09 12.0 0.1 0.16 11.2 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4800) DSPc PF00782.20 CCF44059.1 - 1.1e-25 90.0 0.0 9.6e-20 70.8 0.0 2.3 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 CCF44059.1 - 0.0017 17.9 0.0 0.0099 15.5 0.0 2.0 2 0 0 2 2 2 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 CCF44059.1 - 0.027 14.6 0.2 0.28 11.3 0.1 2.5 3 0 0 3 3 3 0 Inositol hexakisphosphate Med15_fungi PF05397.12 CCF44060.1 - 0.0049 17.1 0.3 0.058 13.7 0.0 2.6 2 0 0 2 2 2 1 Mediator complex subunit 15 DUF918 PF06033.11 CCF44061.1 - 0.01 15.9 0.0 0.012 15.7 0.0 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF918) Catalase PF00199.19 CCF44062.1 - 4.4e-176 585.6 0.3 5e-176 585.5 0.3 1.0 1 0 0 1 1 1 1 Catalase SHMT PF00464.19 CCF44063.1 - 1.1e-207 689.3 0.0 1.3e-207 689.1 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Cys_Met_Meta_PP PF01053.20 CCF44063.1 - 0.014 13.9 0.0 0.023 13.2 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Hce2 PF14856.6 CCF44064.1 - 6.5e-20 71.3 0.0 9.2e-20 70.9 0.0 1.2 1 0 0 1 1 1 1 Pathogen effector; putative necrosis-inducing factor DUF676 PF05057.14 CCF44065.1 - 1e-07 31.7 0.1 1.8e-07 30.9 0.1 1.5 1 1 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.13 CCF44065.1 - 7.1e-05 22.6 0.0 0.0001 22.1 0.0 1.4 1 1 0 1 1 1 1 PGAP1-like protein Abhydrolase_6 PF12697.7 CCF44065.1 - 0.00023 21.8 0.0 0.0003 21.5 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCF44065.1 - 0.00035 19.9 0.2 0.00058 19.2 0.0 1.5 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Lipase_2 PF01674.18 CCF44065.1 - 0.024 14.2 0.0 0.034 13.7 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 2) LCAT PF02450.15 CCF44065.1 - 0.097 11.8 0.0 0.22 10.7 0.0 1.5 1 1 0 1 1 1 0 Lecithin:cholesterol acyltransferase Ser_hydrolase PF06821.13 CCF44065.1 - 0.12 12.2 0.0 0.57 10.0 0.0 2.0 2 1 0 2 2 2 0 Serine hydrolase AAA_16 PF13191.6 CCF44066.1 - 8.1e-09 36.1 0.4 7.1e-08 33.0 0.0 2.3 2 1 0 2 2 2 1 AAA ATPase domain NB-ARC PF00931.22 CCF44066.1 - 0.0034 16.6 0.0 0.0046 16.2 0.0 1.2 1 0 0 1 1 1 1 NB-ARC domain DUF2075 PF09848.9 CCF44066.1 - 0.013 14.8 0.0 0.021 14.1 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) ATPase PF06745.13 CCF44066.1 - 0.018 14.4 0.0 0.038 13.3 0.0 1.4 1 0 0 1 1 1 0 KaiC AAA_33 PF13671.6 CCF44066.1 - 0.02 15.0 0.0 0.078 13.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 CCF44066.1 - 0.023 14.0 0.2 0.46 9.7 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin Viral_helicase1 PF01443.18 CCF44066.1 - 0.04 13.6 0.5 0.84 9.3 0.0 2.8 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase NACHT PF05729.12 CCF44066.1 - 0.056 13.4 0.0 0.12 12.3 0.0 1.7 1 1 0 1 1 1 0 NACHT domain AAA_22 PF13401.6 CCF44066.1 - 0.059 13.6 0.0 0.19 12.0 0.0 1.9 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.12 CCF44066.1 - 0.061 13.1 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain DDE_1 PF03184.19 CCF44069.1 - 5.7e-27 94.5 0.0 8.2e-27 94.0 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_psq PF05225.16 CCF44069.1 - 6.8e-08 32.1 0.1 1.5e-07 31.1 0.1 1.6 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.16 CCF44069.1 - 0.00022 21.2 0.0 0.00057 19.9 0.0 1.8 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DDE_3 PF13358.6 CCF44069.1 - 0.001 18.8 0.0 0.0093 15.7 0.0 2.1 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_AsnC-type PF13404.6 CCF44069.1 - 0.016 15.0 0.1 0.044 13.6 0.1 1.7 1 0 0 1 1 1 0 AsnC-type helix-turn-helix domain HTH_23 PF13384.6 CCF44069.1 - 0.069 13.0 0.1 0.19 11.6 0.1 1.7 1 0 0 1 1 1 0 Homeodomain-like domain Xan_ur_permease PF00860.20 CCF44070.1 - 1.4e-24 86.6 24.4 2.5e-23 82.4 22.6 3.0 2 1 0 2 2 2 1 Permease family MFS_MOT1 PF16983.5 CCF44070.1 - 0.0041 17.5 3.4 0.0041 17.5 3.4 3.4 4 0 0 4 4 4 1 Molybdate transporter of MFS superfamily Astro_capsid_p2 PF16580.5 CCF44070.1 - 0.18 11.2 0.3 0.37 10.2 0.1 1.5 2 0 0 2 2 2 0 C-terminal tail of astrovirus capsid projection or spike SPC25 PF06703.11 CCF44070.1 - 2.4 7.9 4.1 3.1 7.6 0.4 2.5 2 0 0 2 2 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) ECH_1 PF00378.20 CCF44071.1 - 3.8e-11 42.8 0.0 5e-11 42.4 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CCF44071.1 - 1.8e-09 37.6 0.0 2.1e-09 37.4 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase 4HBT_2 PF13279.6 CCF44072.1 - 8.4e-06 26.3 0.0 1.2e-05 25.7 0.0 1.4 1 0 0 1 1 1 1 Thioesterase-like superfamily Fungal_trans PF04082.18 CCF44073.1 - 2.7e-14 52.9 0.0 4.1e-14 52.3 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Ycf9 PF01737.17 CCF44073.1 - 0.096 12.6 0.1 0.25 11.2 0.1 1.7 1 0 0 1 1 1 0 YCF9 bZIP_1 PF00170.21 CCF44074.1 - 1.3e-07 31.6 8.9 4e-07 30.0 8.9 1.8 1 1 0 1 1 1 1 bZIP transcription factor Leu_zip PF15294.6 CCF44074.1 - 0.022 14.3 1.2 0.022 14.3 1.2 1.4 2 0 0 2 2 2 0 Leucine zipper bZIP_2 PF07716.15 CCF44074.1 - 0.72 10.0 11.2 2.4 8.3 6.3 2.5 1 1 1 2 2 2 0 Basic region leucine zipper MDMPI_N PF11716.8 CCF44074.1 - 1.4 9.6 5.3 8.5 7.1 0.2 2.4 1 1 1 2 2 2 0 Mycothiol maleylpyruvate isomerase N-terminal domain DUF501 PF04417.12 CCF44074.1 - 7.2 6.4 6.1 0.78 9.5 1.6 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF501) HTH_psq PF05225.16 CCF44077.1 - 1.5e-11 43.8 0.1 2.8e-11 43.0 0.1 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.16 CCF44077.1 - 2.8e-11 43.3 0.6 1.1e-10 41.3 0.0 2.1 3 0 0 3 3 3 1 Tc5 transposase DNA-binding domain HTH_23 PF13384.6 CCF44077.1 - 0.00015 21.5 0.1 0.00045 19.9 0.1 1.9 1 1 0 1 1 1 1 Homeodomain-like domain HTH_7 PF02796.15 CCF44077.1 - 0.0015 18.5 0.1 0.0031 17.6 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_30 PF13556.6 CCF44077.1 - 0.0025 17.6 0.1 0.0062 16.3 0.1 1.7 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain HTH_28 PF13518.6 CCF44077.1 - 0.006 16.7 0.5 0.017 15.3 0.1 2.1 2 1 1 3 3 3 1 Helix-turn-helix domain HTH_1 PF00126.27 CCF44077.1 - 0.028 14.4 0.3 0.06 13.3 0.2 1.6 1 1 0 1 1 1 0 Bacterial regulatory helix-turn-helix protein, lysR family CENP-B_N PF04218.13 CCF44077.1 - 0.085 12.5 0.0 0.19 11.4 0.0 1.6 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HTH_Tnp_1 PF01527.20 CCF44077.1 - 0.09 13.1 0.4 0.25 11.7 0.4 1.8 1 1 1 2 2 2 0 Transposase HMG_box PF00505.19 CCF44078.1 - 2e-08 34.6 0.2 3.9e-08 33.6 0.2 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 CCF44078.1 - 0.00013 22.5 0.1 0.00038 21.0 0.1 1.9 1 0 0 1 1 1 1 HMG-box domain DUF4058 PF13267.6 CCF44078.1 - 0.16 11.4 1.1 0.18 11.2 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4058) Het-C PF07217.11 CCF44081.1 - 4e-240 798.1 0.0 5e-240 797.8 0.0 1.1 1 0 0 1 1 1 1 Heterokaryon incompatibility protein Het-C Tti2 PF10521.9 CCF44081.1 - 0.078 12.5 0.2 6.6 6.2 0.0 2.5 2 1 0 2 2 2 0 Tti2 family DUF2547 PF10818.8 CCF44081.1 - 0.22 12.4 0.7 0.64 11.0 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2547) DDE_1 PF03184.19 CCF44083.1 - 3.4e-13 49.6 0.0 7.4e-13 48.5 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_psq PF05225.16 CCF44083.1 - 1.1e-08 34.6 0.0 1.9e-08 33.9 0.0 1.4 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.16 CCF44083.1 - 6.4e-08 32.5 0.0 1.5e-07 31.3 0.0 1.6 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_23 PF13384.6 CCF44083.1 - 0.0022 17.7 0.0 0.0077 16.0 0.0 1.9 1 0 0 1 1 1 1 Homeodomain-like domain Vps16_C PF04840.12 CCF44084.1 - 0.037 13.1 0.0 0.056 12.5 0.0 1.1 1 0 0 1 1 1 0 Vps16, C-terminal region Mur_ligase PF01225.25 CCF44084.1 - 0.14 12.5 0.1 0.48 10.8 0.0 1.9 2 0 0 2 2 2 0 Mur ligase family, catalytic domain AAA PF00004.29 CCF44085.1 - 8e-16 58.7 0.0 4.7e-15 56.2 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CCF44085.1 - 3e-11 44.0 0.0 1.4e-09 38.6 0.0 2.8 2 1 0 2 2 2 1 AAA ATPase domain BAH PF01426.18 CCF44085.1 - 8.4e-11 41.8 0.0 2.2e-10 40.4 0.0 1.6 2 0 0 2 2 2 1 BAH domain AAA_22 PF13401.6 CCF44085.1 - 4.5e-09 36.7 0.0 6e-08 33.1 0.0 2.1 2 0 0 2 2 2 1 AAA domain ATPase_2 PF01637.18 CCF44085.1 - 0.0038 17.2 0.0 0.14 12.1 0.0 2.4 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_19 PF13245.6 CCF44085.1 - 0.0047 17.3 0.0 0.013 15.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 CCF44085.1 - 0.0075 15.6 0.0 0.012 14.9 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_18 PF13238.6 CCF44085.1 - 0.015 15.9 0.0 0.034 14.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 CCF44085.1 - 0.053 13.3 0.0 0.096 12.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 CCF44085.1 - 0.079 12.9 0.0 0.17 11.8 0.0 1.5 1 1 0 1 1 1 0 NACHT domain Baculo_11_kDa PF06143.11 CCF44085.1 - 0.17 11.5 0.0 0.37 10.4 0.0 1.5 1 0 0 1 1 1 0 Baculovirus 11 kDa family AAA_32 PF13654.6 CCF44085.1 - 0.18 10.6 0.0 0.3 9.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain MFS_1 PF07690.16 CCF44086.1 - 1.7e-31 109.4 18.6 1.7e-31 109.4 18.6 1.6 1 1 1 2 2 2 1 Major Facilitator Superfamily MgtC PF02308.16 CCF44086.1 - 0.61 10.5 4.6 1.1 9.6 0.1 2.7 3 0 0 3 3 3 0 MgtC family Cation_ATPase_C PF00689.21 CCF44086.1 - 4.3 7.0 0.0 4.3 7.0 0.0 4.1 3 2 1 4 4 4 0 Cation transporting ATPase, C-terminus Pkinase PF00069.25 CCF44089.1 - 4.4e-61 206.6 0.0 5.7e-61 206.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF44089.1 - 4.3e-28 98.3 0.0 7.8e-28 97.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF44089.1 - 0.0012 18.2 0.0 0.0021 17.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 CCF44089.1 - 0.04 13.3 0.0 0.068 12.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CCF44089.1 - 0.055 13.4 0.0 0.055 13.4 0.0 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 CCF44089.1 - 0.079 11.9 0.0 0.11 11.4 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain LpxI_C PF06230.11 CCF44089.1 - 0.11 12.3 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 LpxI C-terminal domain Methyltransf_28 PF02636.17 CCF44090.1 - 5e-82 275.5 0.0 6.5e-82 275.1 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase STAR_dimer PF16544.5 CCF44090.1 - 0.027 14.1 0.0 0.048 13.2 0.0 1.4 1 0 0 1 1 1 0 Homodimerisation region of STAR domain protein Lung_7-TM_R PF06814.13 CCF44091.1 - 1.2e-70 238.1 16.0 1.5e-70 237.8 16.0 1.1 1 0 0 1 1 1 1 Lung seven transmembrane receptor DUF4492 PF14899.6 CCF44091.1 - 1.3 8.9 4.8 0.51 10.3 1.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4492) DUF1980 PF09323.10 CCF44091.1 - 3.2 7.7 5.4 0.87 9.5 0.2 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF1980) Pro_isomerase PF00160.21 CCF44092.1 - 9.8e-49 165.7 0.0 1.7e-48 164.9 0.0 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD U-box PF04564.15 CCF44092.1 - 0.0006 19.9 0.0 0.0022 18.2 0.0 1.9 1 0 0 1 1 1 1 U-box domain zf-NOSIP PF15906.5 CCF44092.1 - 0.00083 19.5 0.0 0.0023 18.0 0.0 1.7 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein Fungal_trans_2 PF11951.8 CCF44093.1 - 3.8e-09 35.9 0.1 7.8e-07 28.2 0.0 2.1 2 0 0 2 2 2 2 Fungal specific transcription factor domain Flu_M1_C PF08289.11 CCF44093.1 - 0.015 15.5 0.0 0.046 13.9 0.0 1.7 1 0 0 1 1 1 0 Influenza Matrix protein (M1) C-terminal domain FAD_binding_3 PF01494.19 CCF44095.1 - 8.9e-09 35.0 0.0 8.9e-09 35.0 0.0 1.0 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 CCF44095.1 - 0.0016 19.0 0.2 0.0024 18.4 0.2 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCF44095.1 - 0.0018 18.0 0.1 0.0018 18.0 0.1 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CCF44095.1 - 0.0026 18.0 0.1 0.0054 16.9 0.1 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CCF44095.1 - 0.018 14.3 0.1 0.024 13.9 0.1 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 CCF44095.1 - 0.2 10.7 0.1 0.26 10.3 0.1 1.1 1 0 0 1 1 1 0 Lycopene cyclase protein Nucleos_tra2_C PF07662.13 CCF44097.1 - 8.9e-69 231.5 5.0 8.9e-69 231.5 5.0 2.7 3 0 0 3 3 3 1 Na+ dependent nucleoside transporter C-terminus Nucleos_tra2_N PF01773.20 CCF44097.1 - 8.7e-24 83.9 1.2 8.7e-24 83.9 1.2 2.9 1 1 1 2 2 2 1 Na+ dependent nucleoside transporter N-terminus Gate PF07670.14 CCF44097.1 - 0.012 15.9 6.7 0.012 15.9 6.7 3.4 3 1 0 3 3 3 0 Nucleoside recognition adh_short PF00106.25 CCF44099.1 - 5.9e-20 71.6 0.0 7.4e-19 68.0 0.0 2.1 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF44099.1 - 8.1e-10 38.7 0.0 1.6e-09 37.7 0.0 1.4 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF44099.1 - 1e-06 28.8 0.2 1.7e-06 28.1 0.2 1.3 1 0 0 1 1 1 1 KR domain ArgoN PF16486.5 CCF44100.1 - 0.086 13.5 0.6 0.19 12.4 0.6 1.5 1 0 0 1 1 1 0 N-terminal domain of argonaute Peptidase_M14 PF00246.24 CCF44101.1 - 3.5e-66 224.0 0.0 4.3e-66 223.7 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.16 CCF44101.1 - 0.00016 22.0 0.3 0.00031 21.1 0.3 1.5 1 0 0 1 1 1 1 Carboxypeptidase activation peptide Secretin_N_2 PF07655.13 CCF44102.1 - 0.003 18.1 1.9 0.0058 17.1 1.9 1.5 1 0 0 1 1 1 1 Secretin N-terminal domain Peptidase_S8 PF00082.22 CCF44103.1 - 8e-36 123.8 0.0 1.5e-35 122.9 0.0 1.4 1 1 0 1 1 1 1 Subtilase family fn3_5 PF06280.12 CCF44103.1 - 3.3e-20 72.9 0.0 1.4e-19 70.9 0.0 2.1 2 0 0 2 2 2 1 Fn3-like domain DUF756 PF05506.12 CCF44103.1 - 0.097 13.6 0.1 5.4 8.0 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF756) Fungal_trans_2 PF11951.8 CCF44104.1 - 3.6e-52 177.5 0.2 4.9e-52 177.0 0.2 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF44104.1 - 1e-06 28.7 4.7 2e-06 27.8 4.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4281 PF14108.6 CCF44104.1 - 0.12 12.7 0.2 0.12 12.7 0.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4281) PBP PF01161.20 CCF44105.1 - 8.1e-10 39.1 0.0 1.2e-09 38.6 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein Secretin_N_2 PF07655.13 CCF44105.1 - 0.22 12.1 8.4 0.43 11.2 8.4 1.4 1 0 0 1 1 1 0 Secretin N-terminal domain Pkinase PF00069.25 CCF44106.1 - 6.3e-10 38.9 0.0 9.2e-10 38.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 CCF44106.1 - 0.00028 20.3 0.0 0.00041 19.8 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_Tyr PF07714.17 CCF44106.1 - 0.00039 19.8 0.0 0.00053 19.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CCF44106.1 - 0.0014 18.6 0.2 0.0064 16.4 0.1 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family WaaY PF06176.11 CCF44106.1 - 0.11 12.1 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) DNA_pol_alpha_N PF12254.8 CCF44107.1 - 8.1e-24 83.5 10.1 8.1e-24 83.5 10.1 2.3 2 0 0 2 2 2 1 DNA polymerase alpha subunit p180 N terminal AT_hook PF02178.19 CCF44107.1 - 1.9 8.6 9.2 0.35 10.9 2.7 2.8 2 0 0 2 2 2 0 AT hook motif ABC_membrane PF00664.23 CCF44108.1 - 2.4e-38 132.4 7.3 3.1e-38 132.0 7.3 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 CCF44108.1 - 2.1e-34 119.0 0.0 3.8e-34 118.1 0.0 1.4 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 CCF44108.1 - 2.8e-07 30.2 0.0 9.5e-05 21.9 0.0 2.5 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_30 PF13604.6 CCF44108.1 - 0.00039 20.2 0.3 0.002 17.9 0.2 2.1 1 1 0 1 1 1 1 AAA domain ABC_ATPase PF09818.9 CCF44108.1 - 0.00089 18.2 0.0 0.0018 17.1 0.0 1.4 1 0 0 1 1 1 1 Predicted ATPase of the ABC class AAA_22 PF13401.6 CCF44108.1 - 0.0033 17.7 0.1 0.086 13.1 0.0 2.7 3 0 0 3 3 3 1 AAA domain AAA_29 PF13555.6 CCF44108.1 - 0.0037 17.0 0.0 0.0084 15.8 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.6 CCF44108.1 - 0.0059 16.5 0.1 0.24 11.2 0.0 2.2 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 CCF44108.1 - 0.015 15.7 0.2 0.039 14.3 0.2 1.8 1 1 0 1 1 1 0 AAA ATPase domain DUF3987 PF13148.6 CCF44108.1 - 0.058 12.4 0.1 0.11 11.5 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) RsgA_GTPase PF03193.16 CCF44108.1 - 0.08 12.9 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase PRK PF00485.18 CCF44108.1 - 0.082 12.6 0.1 0.15 11.7 0.1 1.4 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family AAA PF00004.29 CCF44108.1 - 0.14 12.6 0.1 1.6 9.2 0.0 2.4 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 CCF44108.1 - 0.16 11.9 0.0 0.32 10.9 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain SbcCD_C PF13558.6 CCF44108.1 - 0.19 12.0 0.6 1.7 8.9 0.6 2.4 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit Rhomboid PF01694.22 CCF44108.1 - 0.48 10.4 6.4 1.7 8.7 6.4 2.0 1 1 0 1 1 1 0 Rhomboid family ABC2_membrane PF01061.24 CCF44109.1 - 2.9e-18 66.1 12.7 2.9e-18 66.1 12.7 1.9 2 0 0 2 2 2 1 ABC-2 type transporter ABC2_membrane_3 PF12698.7 CCF44109.1 - 0.00028 20.1 10.2 0.0004 19.6 10.2 1.3 1 1 0 1 1 1 1 ABC-2 family transporter protein NACHT PF05729.12 CCF44110.1 - 1.3e-10 41.4 0.0 2.3e-10 40.6 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 CCF44110.1 - 1.9e-07 31.7 0.0 2.6e-07 31.2 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 CCF44110.1 - 1.8e-05 25.0 0.1 6.9e-05 23.1 0.1 1.9 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 CCF44110.1 - 4e-05 24.0 0.1 0.0012 19.2 0.0 2.2 2 0 0 2 2 2 1 RNA helicase AAA PF00004.29 CCF44110.1 - 0.00057 20.3 0.1 0.004 17.6 0.1 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) XPC-binding PF09280.11 CCF44110.1 - 0.0025 17.5 1.1 0.0049 16.6 0.1 1.9 2 0 0 2 2 2 1 XPC-binding domain AAA_33 PF13671.6 CCF44110.1 - 0.0094 16.1 0.0 0.014 15.6 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CCF44110.1 - 0.017 15.5 0.5 0.11 12.9 0.5 1.9 1 1 0 1 1 1 0 AAA domain Torsin PF06309.11 CCF44110.1 - 0.044 13.9 0.0 0.36 11.0 0.0 2.0 2 0 0 2 2 2 0 Torsin AAA_18 PF13238.6 CCF44110.1 - 0.055 14.0 0.0 0.1 13.1 0.0 1.5 1 1 0 1 1 1 0 AAA domain KAP_NTPase PF07693.14 CCF44110.1 - 0.071 12.3 0.0 0.57 9.4 0.0 1.9 2 0 0 2 2 2 0 KAP family P-loop domain AAA_5 PF07728.14 CCF44110.1 - 0.073 13.1 0.0 1 9.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 CCF44110.1 - 0.088 12.5 0.1 0.19 11.4 0.0 1.5 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain APS_kinase PF01583.20 CCF44110.1 - 0.098 12.5 0.2 0.16 11.9 0.2 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_24 PF13479.6 CCF44110.1 - 0.11 12.2 0.1 0.18 11.5 0.1 1.4 1 1 0 1 1 1 0 AAA domain Ploopntkinase3 PF18751.1 CCF44110.1 - 0.12 12.3 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 DUF2075 PF09848.9 CCF44110.1 - 0.19 10.9 0.0 0.27 10.4 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Helicase_C PF00271.31 CCF44111.1 - 8.4e-05 22.9 0.0 0.00024 21.4 0.0 1.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Pkinase PF00069.25 CCF44112.1 - 5.4e-73 245.6 0.0 8.8e-73 244.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF44112.1 - 1.7e-36 125.8 0.0 4.3e-36 124.5 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF44112.1 - 0.00091 18.6 0.1 1 8.6 0.0 2.6 2 0 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 CCF44112.1 - 0.021 13.6 0.5 0.075 11.8 0.0 2.0 2 0 0 2 2 2 0 Fungal protein kinase APH PF01636.23 CCF44112.1 - 0.027 14.4 1.3 0.13 12.1 0.0 2.5 2 2 1 3 3 3 0 Phosphotransferase enzyme family Connexin PF00029.19 CCF44112.1 - 0.97 9.1 2.6 1.9 8.2 2.6 1.5 1 0 0 1 1 1 0 Connexin R3H-assoc PF13902.6 CCF44112.1 - 2.2 8.7 8.7 0.61 10.5 2.8 2.3 2 0 0 2 2 2 0 R3H-associated N-terminal domain DASH_Spc34 PF08657.10 CCF44114.1 - 2.4e-15 57.1 2.0 2.8e-15 56.8 2.0 1.0 1 0 0 1 1 1 1 DASH complex subunit Spc34 Cwf_Cwc_15 PF04889.12 CCF44114.1 - 0.019 14.7 6.3 0.021 14.5 6.3 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein SlyX PF04102.12 CCF44114.1 - 0.052 14.2 0.8 0.052 14.2 0.8 2.1 1 1 1 2 2 2 0 SlyX BBS2_C PF14782.6 CCF44114.1 - 0.077 11.7 1.0 0.13 11.0 1.0 1.3 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, C-terminal CRA PF06589.11 CCF44114.1 - 0.68 10.0 3.4 0.87 9.7 3.4 1.2 1 0 0 1 1 1 0 Circumsporozoite-related antigen (CRA) UPF0242 PF06785.11 CCF44114.1 - 3.6 7.6 7.7 7.2 6.7 7.7 1.4 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DSBA PF01323.20 CCF44115.1 - 2.5e-32 112.2 0.0 2.9e-32 112.0 0.0 1.0 1 0 0 1 1 1 1 DSBA-like thioredoxin domain Thioredoxin_3 PF13192.6 CCF44115.1 - 2.2e-05 24.4 0.1 0.0006 19.8 0.1 2.5 2 1 0 2 2 2 1 Thioredoxin domain Thioredoxin_2 PF13098.6 CCF44115.1 - 0.0023 18.4 0.1 0.033 14.7 0.0 2.2 2 1 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_4 PF13462.6 CCF44115.1 - 0.0025 18.0 0.0 0.0045 17.1 0.0 1.5 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_5 PF13743.6 CCF44115.1 - 0.0035 17.1 0.0 0.026 14.2 0.0 1.9 2 0 0 2 2 2 1 Thioredoxin DUF1525 PF07511.11 CCF44115.1 - 0.064 13.4 0.0 0.13 12.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1525) Pox_Ag35 PF03286.14 CCF44116.1 - 1.4 8.6 17.8 0.034 13.9 9.6 2.2 2 0 0 2 2 2 0 Pox virus Ag35 surface protein NOA36 PF06524.12 CCF44116.1 - 2.4 7.4 12.0 3.8 6.7 12.0 1.3 1 0 0 1 1 1 0 NOA36 protein DNA_pol_phi PF04931.13 CCF44116.1 - 8.2 4.4 18.9 11 4.0 18.9 1.2 1 0 0 1 1 1 0 DNA polymerase phi CDC45 PF02724.14 CCF44116.1 - 9.5 4.4 11.7 12 4.0 11.7 1.2 1 0 0 1 1 1 0 CDC45-like protein Aminotran_1_2 PF00155.21 CCF44120.1 - 1e-58 199.3 0.0 1.3e-58 198.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 CCF44120.1 - 0.05 12.4 0.0 0.062 12.1 0.0 1.3 1 0 0 1 1 1 0 Alanine-glyoxylate amino-transferase Torus PF16131.5 CCF44120.1 - 0.19 12.4 0.0 0.4 11.4 0.0 1.5 1 0 0 1 1 1 0 Torus domain TruD PF01142.18 CCF44120.1 - 0.21 10.4 0.0 0.3 9.9 0.0 1.1 1 0 0 1 1 1 0 tRNA pseudouridine synthase D (TruD) HpcH_HpaI PF03328.14 CCF44121.1 - 0.028 13.6 0.0 0.028 13.5 0.0 1.2 1 0 0 1 1 1 0 HpcH/HpaI aldolase/citrate lyase family Halogen_Hydrol PF10112.9 CCF44122.1 - 0.024 14.7 0.2 0.027 14.5 0.2 1.0 1 0 0 1 1 1 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein Pkinase PF00069.25 CCF44123.1 - 3e-55 187.4 0.0 4.4e-55 186.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF44123.1 - 2.5e-32 112.2 0.0 9.1e-31 107.1 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Haspin_kinase PF12330.8 CCF44123.1 - 0.0027 16.7 0.0 0.0039 16.2 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Pox_ser-thr_kin PF05445.11 CCF44123.1 - 0.026 13.5 0.0 0.036 13.0 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Kdo PF06293.14 CCF44123.1 - 0.12 11.7 1.1 0.2 11.0 1.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family F-box-like PF12937.7 CCF44124.1 - 0.013 15.4 0.0 0.051 13.5 0.0 2.1 1 0 0 1 1 1 0 F-box-like Fungal_trans_2 PF11951.8 CCF44125.1 - 4.6e-27 94.8 1.4 1.5e-26 93.1 1.4 1.8 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF44125.1 - 9.7e-09 35.2 5.5 1.5e-08 34.6 5.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Kinesin PF00225.23 CCF44127.1 - 1.2e-106 356.4 0.0 1.9e-106 355.7 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain Kinesin_assoc PF16183.5 CCF44127.1 - 8.7e-37 127.0 9.9 1.5e-35 123.0 2.9 3.1 3 1 0 3 3 3 1 Kinesin-associated Microtub_bd PF16796.5 CCF44127.1 - 3e-22 79.2 0.0 9.7e-22 77.5 0.0 1.9 1 0 0 1 1 1 1 Microtubule binding FHA PF00498.26 CCF44127.1 - 0.00022 21.5 0.0 0.0019 18.5 0.0 2.3 2 0 0 2 2 2 1 FHA domain UPF0242 PF06785.11 CCF44127.1 - 0.054 13.6 7.3 1.1 9.3 0.1 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Yop-YscD_cpl PF16697.5 CCF44127.1 - 0.13 12.6 0.0 0.41 11.0 0.0 1.8 1 0 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain Arm-DNA-bind_5 PF17293.2 CCF44127.1 - 0.18 12.3 3.1 0.26 11.7 0.2 2.7 2 0 0 2 2 2 0 Arm DNA-binding domain FEZ PF07763.13 CCF44127.1 - 7 6.3 15.6 1.9 8.2 1.0 3.4 3 0 0 3 3 3 0 FEZ-like protein ATP-synt_E PF05680.12 CCF44129.1 - 1.1e-25 89.7 0.1 1.2e-25 89.6 0.1 1.0 1 0 0 1 1 1 1 ATP synthase E chain Drf_GBD PF06371.13 CCF44129.1 - 0.035 13.7 0.1 0.036 13.6 0.1 1.1 1 0 0 1 1 1 0 Diaphanous GTPase-binding Domain STT3 PF02516.14 CCF44130.1 - 3.4e-136 455.0 34.7 2.4e-131 439.0 32.3 2.1 2 0 0 2 2 2 2 Oligosaccharyl transferase STT3 subunit DUF5001 PF16392.5 CCF44131.1 - 0.034 14.1 0.0 0.067 13.1 0.0 1.4 1 0 0 1 1 1 0 Ig-like domain CoA_trans PF01144.23 CCF44132.1 - 2.1e-68 229.9 0.1 7.8e-59 198.7 0.4 2.1 2 0 0 2 2 2 2 Coenzyme A transferase Mal_decarbox_Al PF16957.5 CCF44132.1 - 0.00078 17.9 0.1 0.0011 17.3 0.1 1.1 1 0 0 1 1 1 1 Malonate decarboxylase, alpha subunit, transporter MFS_1 PF07690.16 CCF44133.1 - 0.048 12.6 0.1 0.055 12.4 0.1 1.0 1 0 0 1 1 1 0 Major Facilitator Superfamily Cdc6_C PF09079.11 CCF44134.1 - 4.9e-08 32.8 0.2 6.5e-07 29.2 0.2 2.5 1 1 0 1 1 1 1 CDC6, C terminal winged helix domain AAA_lid_10 PF17872.1 CCF44134.1 - 6.6e-06 26.2 0.0 1.6e-05 24.9 0.0 1.6 1 0 0 1 1 1 1 AAA lid domain AAA PF00004.29 CCF44134.1 - 0.00034 21.0 0.0 0.0012 19.3 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CCF44134.1 - 0.0015 18.8 0.7 0.0034 17.7 0.1 1.9 2 0 0 2 2 2 1 AAA domain TniB PF05621.11 CCF44134.1 - 0.018 14.5 0.0 0.035 13.5 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein Pyr_redox_2 PF07992.14 CCF44136.1 - 4.3e-25 88.5 0.1 5.2e-25 88.3 0.1 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCF44136.1 - 1.7e-15 57.3 4.4 5.2e-14 52.6 0.3 2.9 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CCF44136.1 - 4.3e-05 23.5 0.1 0.63 10.0 0.0 3.1 3 0 0 3 3 3 2 FAD-NAD(P)-binding Amino_oxidase PF01593.24 CCF44136.1 - 0.00057 19.3 0.6 0.036 13.4 0.2 2.0 1 1 1 2 2 2 1 Flavin containing amine oxidoreductase GIDA PF01134.22 CCF44136.1 - 0.016 14.3 0.1 4.3 6.3 0.0 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A DUF2184 PF09950.9 CCF44136.1 - 0.057 12.8 0.0 0.22 10.9 0.0 1.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2184) NAD_binding_7 PF13241.6 CCF44136.1 - 0.07 13.6 0.1 1.9 9.0 0.0 2.3 2 1 0 2 2 2 0 Putative NAD(P)-binding Pyr_redox_3 PF13738.6 CCF44136.1 - 0.15 11.3 0.0 6.1 6.0 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 CCF44136.1 - 0.16 11.2 1.2 3.1 7.0 0.2 2.2 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain K_oxygenase PF13434.6 CCF44136.1 - 0.17 11.0 0.0 0.59 9.2 0.0 1.7 1 1 1 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) Glu_dehyd_C PF16912.5 CCF44136.1 - 0.26 10.8 1.5 19 4.6 0.1 2.7 2 1 1 3 3 3 0 Glucose dehydrogenase C-terminus ADK PF00406.22 CCF44138.1 - 4.6e-22 78.7 0.0 5.4e-22 78.5 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 CCF44138.1 - 1.2e-14 54.8 0.0 1.6e-14 54.5 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CCF44138.1 - 0.11 13.1 0.0 0.15 12.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain MFS_1 PF07690.16 CCF44139.1 - 9.7e-06 24.7 16.7 1.2e-05 24.4 16.7 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF1295 PF06966.12 CCF44139.1 - 0.035 13.6 0.8 0.053 13.0 0.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1295) BRX_N PF13713.6 CCF44139.1 - 0.19 11.5 0.1 0.27 11.0 0.1 1.2 1 0 0 1 1 1 0 Transcription factor BRX N-terminal domain TcpE PF12648.7 CCF44139.1 - 0.19 12.3 0.3 0.19 12.3 0.3 1.7 2 0 0 2 2 2 0 TcpE family WSC PF01822.19 CCF44141.1 - 5.7e-16 58.5 9.7 5.7e-16 58.5 9.7 2.9 3 1 0 3 3 3 1 WSC domain CFEM PF05730.11 CCF44141.1 - 5.4e-12 45.6 15.0 8.5e-12 45.0 5.2 2.7 2 0 0 2 2 2 2 CFEM domain p450 PF00067.22 CCF44143.1 - 6.3e-09 35.1 0.2 7e-09 34.9 0.2 1.0 1 0 0 1 1 1 1 Cytochrome P450 AMP-binding PF00501.28 CCF44144.1 - 5.1e-35 120.9 0.4 7.1e-35 120.4 0.4 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding PF00501.28 CCF44145.1 - 7e-15 54.5 0.0 1e-14 54.0 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.25 CCF44145.1 - 1.4e-12 47.7 0.2 3.6e-12 46.4 0.0 1.8 2 0 0 2 2 2 1 Phosphopantetheine attachment site AMP-binding_C PF13193.6 CCF44145.1 - 0.00089 20.2 0.7 0.003 18.5 0.0 2.2 3 0 0 3 3 3 1 AMP-binding enzyme C-terminal domain p450 PF00067.22 CCF44146.1 - 3.4e-31 108.5 0.0 4.3e-31 108.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 CCF44147.1 - 4.6e-32 111.4 0.0 8.3e-32 110.5 0.0 1.4 1 1 0 1 1 1 1 Cytochrome P450 Arylsulfotran_2 PF14269.6 CCF44150.1 - 1.3e-50 172.5 0.0 1.6e-50 172.2 0.0 1.1 1 0 0 1 1 1 1 Arylsulfotransferase (ASST) Arylsulfotrans PF05935.11 CCF44150.1 - 1.4e-17 63.7 0.0 4.4e-16 58.8 0.0 2.4 2 1 0 2 2 2 1 Arylsulfotransferase (ASST) Glyco_hydro_2_C PF02836.17 CCF44152.1 - 1.7e-100 336.1 0.1 2.6e-100 335.5 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2_N PF02837.18 CCF44152.1 - 1.9e-39 135.3 0.3 3.7e-39 134.3 0.3 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain DUF4981 PF16353.5 CCF44152.1 - 8.9e-24 83.8 0.0 2.4e-23 82.4 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function(DUF4981) Glyco_hydro_2 PF00703.21 CCF44152.1 - 3.7e-11 43.7 0.0 4.8e-10 40.1 0.0 2.4 2 0 0 2 2 2 1 Glycosyl hydrolases family 2 BetaGal_dom4_5 PF13364.6 CCF44152.1 - 0.003 18.1 1.2 0.0087 16.6 0.0 2.3 3 0 0 3 3 3 1 Beta-galactosidase jelly roll domain Oxidored_FMN PF00724.20 CCF44153.1 - 2.8e-35 122.2 0.0 3.3e-35 122.0 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Rhabdo_NV PF02484.15 CCF44153.1 - 0.15 12.2 0.0 0.2 11.8 0.0 1.3 1 0 0 1 1 1 0 Rhabdovirus Non-virion protein Sugar_tr PF00083.24 CCF44155.1 - 3.6e-61 207.4 13.0 4e-61 207.3 13.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF44155.1 - 5.4e-10 38.7 27.3 1.9e-05 23.8 15.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Peptidase_M35 PF02102.15 CCF44156.1 - 2.2e-29 102.4 1.3 2.6e-29 102.2 1.3 1.0 1 0 0 1 1 1 1 Deuterolysin metalloprotease (M35) family Aspzincin_M35 PF14521.6 CCF44156.1 - 0.00034 21.2 0.1 0.00057 20.5 0.1 1.5 1 0 0 1 1 1 1 Lysine-specific metallo-endopeptidase GFO_IDH_MocA PF01408.22 CCF44157.1 - 9.3e-17 62.0 0.0 1.4e-16 61.4 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Sugar_tr PF00083.24 CCF44158.1 - 1.5e-87 294.4 16.7 1.7e-87 294.2 16.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF44158.1 - 3.4e-33 115.0 44.5 2.4e-25 89.2 24.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 CCF44158.1 - 0.00092 17.6 0.3 0.78 8.0 0.2 3.0 3 0 0 3 3 3 2 Organic Anion Transporter Polypeptide (OATP) family GFO_IDH_MocA PF01408.22 CCF44159.1 - 1.3e-17 64.8 0.0 3.5e-17 63.3 0.0 1.8 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold Arm_3 PF16186.5 CCF44159.1 - 0.14 11.8 0.0 0.36 10.4 0.0 1.6 1 0 0 1 1 1 0 Atypical Arm repeat Cytomega_UL20A PF05984.12 CCF44160.1 - 0.025 14.9 1.8 0.042 14.2 0.0 2.0 2 1 0 2 2 2 0 Cytomegalovirus UL20A protein Asparaginase_2 PF01112.18 CCF44160.1 - 0.83 8.6 5.0 0.93 8.5 5.0 1.1 1 0 0 1 1 1 0 Asparaginase Lamprin PF06403.11 CCF44160.1 - 2 8.4 6.6 5.3 7.0 6.6 1.7 1 1 0 1 1 1 0 Lamprin Zn_clus PF00172.18 CCF44161.1 - 7.8e-10 38.7 11.8 1.2e-09 38.2 11.8 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF908 PF06012.12 CCF44161.1 - 0.0075 15.7 0.1 0.0094 15.4 0.1 1.1 1 0 0 1 1 1 1 Domain of Unknown Function (DUF908) zf-C2H2 PF00096.26 CCF44162.1 - 0.00078 19.8 4.2 0.00078 19.8 4.2 3.8 3 1 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCF44162.1 - 0.045 14.6 3.1 0.045 14.6 3.1 3.9 3 0 0 3 3 3 0 C2H2-type zinc finger YdjO PF14169.6 CCF44162.1 - 0.07 12.9 0.2 5.8 6.7 0.1 2.6 2 0 0 2 2 2 0 Cold-inducible protein YdjO Egh16-like PF11327.8 CCF44163.1 - 2.1e-50 171.7 8.8 2.5e-50 171.4 8.8 1.1 1 0 0 1 1 1 1 Egh16-like virulence factor PS-DH PF14765.6 CCF44164.1 - 1.8e-56 191.6 0.0 2.8e-56 191.0 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 CCF44164.1 - 1.3e-51 176.0 0.5 4.4e-51 174.3 0.5 1.8 1 1 0 1 1 1 1 Acyl transferase domain SAT PF16073.5 CCF44164.1 - 0.00071 19.4 2.3 0.029 14.1 0.3 3.1 2 1 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis KAsynt_C_assoc PF16197.5 CCF44164.1 - 0.0011 19.4 0.3 0.0056 17.1 0.0 2.3 2 0 0 2 2 2 1 Ketoacyl-synthetase C-terminal extension Dioxygenase_C PF00775.21 CCF44165.1 - 9.7e-07 28.4 0.0 2.3e-05 23.9 0.0 2.2 2 0 0 2 2 2 2 Dioxygenase PufQ PF05398.11 CCF44166.1 - 0.32 11.1 2.6 6.7 6.9 0.0 3.3 4 0 0 4 4 4 0 PufQ cytochrome subunit S1-P1_nuclease PF02265.16 CCF44167.1 - 9.9e-62 209.0 0.0 1.1e-61 208.8 0.0 1.0 1 0 0 1 1 1 1 S1/P1 Nuclease Na_H_Exchanger PF00999.21 CCF44171.1 - 1.2e-37 129.6 10.3 1.5e-37 129.3 10.3 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family TPP_enzyme_N PF02776.18 CCF44172.1 - 1.2e-32 112.8 0.2 1.7e-29 102.6 0.1 3.8 3 1 0 3 3 3 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 CCF44172.1 - 6.9e-23 81.1 0.1 1.7e-22 79.9 0.0 1.8 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 CCF44172.1 - 1.7e-13 50.5 0.0 1.1e-12 47.8 0.0 2.1 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain FtsX PF02687.21 CCF44173.1 - 0.13 12.8 1.2 2.9 8.4 0.2 2.1 2 0 0 2 2 2 0 FtsX-like permease family DUF4267 PF14087.6 CCF44174.1 - 9.7e-21 73.9 4.0 1.1e-20 73.7 4.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4267) zf-RING_5 PF14634.6 CCF44175.1 - 2.8e-05 24.0 0.8 2.8e-05 24.0 0.8 2.6 2 2 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 CCF44175.1 - 0.0002 21.1 3.1 0.0002 21.1 3.1 2.2 2 1 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 CCF44175.1 - 0.00026 20.8 1.1 0.00026 20.8 1.1 3.2 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CCF44175.1 - 0.00084 19.6 8.6 0.00084 19.6 8.6 3.1 2 2 0 2 2 1 1 Ring finger domain zf-rbx1 PF12678.7 CCF44175.1 - 0.019 15.3 7.3 0.071 13.4 7.3 2.1 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 CCF44175.1 - 0.019 15.0 1.1 0.019 15.0 1.1 2.8 2 1 0 2 2 2 0 RING-type zinc-finger zf-C3HC4_4 PF15227.6 CCF44175.1 - 0.021 15.0 0.2 0.021 15.0 0.2 2.1 2 0 0 2 2 1 0 zinc finger of C3HC4-type, RING zf-ANAPC11 PF12861.7 CCF44175.1 - 0.028 14.5 3.3 0.066 13.3 3.3 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger DTHCT PF08070.11 CCF44175.1 - 0.052 14.3 18.1 0.045 14.5 16.3 1.8 1 1 1 2 2 2 0 DTHCT (NUC029) region Pellino PF04710.14 CCF44175.1 - 0.33 9.6 2.0 0.52 8.9 2.0 1.2 1 0 0 1 1 1 0 Pellino zf-C3HC4 PF00097.25 CCF44175.1 - 0.51 10.3 5.8 0.18 11.7 1.7 2.4 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) C1_2 PF03107.16 CCF44175.1 - 1.1 9.6 7.2 7.2 7.0 0.1 3.3 3 0 0 3 3 3 0 C1 domain BUD22 PF09073.10 CCF44175.1 - 1.2 8.4 16.7 1.9 7.8 16.7 1.3 1 0 0 1 1 1 0 BUD22 DZR PF12773.7 CCF44175.1 - 9.6 6.3 10.1 45 4.2 3.5 2.7 1 1 1 2 2 2 0 Double zinc ribbon MFS_1 PF07690.16 CCF44176.1 - 5.1e-36 124.3 36.4 5.1e-36 124.3 36.4 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily FGGY_N PF00370.21 CCF44176.1 - 0.02 14.4 0.0 0.035 13.7 0.0 1.3 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, N-terminal domain adh_short_C2 PF13561.6 CCF44177.1 - 1.4e-51 175.3 0.1 2.2e-51 174.7 0.1 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF44177.1 - 1.3e-46 158.6 0.2 1.7e-46 158.2 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF44177.1 - 6.4e-09 36.0 0.1 1e-08 35.3 0.1 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF44177.1 - 0.047 13.1 0.2 0.1 12.0 0.2 1.5 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Fungal_trans_2 PF11951.8 CCF44178.1 - 8.8e-17 61.0 0.0 1.6e-15 56.8 0.0 2.0 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF44178.1 - 4.6e-06 26.7 13.9 8.6e-06 25.8 13.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Transketolase_N PF00456.21 CCF44179.1 - 3.7e-125 417.3 0.0 5.7e-125 416.7 0.0 1.3 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 CCF44179.1 - 4.5e-36 124.2 0.0 1.2e-35 122.8 0.0 1.7 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 CCF44179.1 - 7e-07 29.2 0.0 1.7e-06 27.9 0.0 1.7 1 1 0 1 1 1 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.6 CCF44179.1 - 1.2e-06 28.0 0.0 3.1e-06 26.6 0.0 1.7 1 1 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase E1_dh PF00676.20 CCF44179.1 - 2.3e-06 26.8 0.3 3.8e-06 26.1 0.3 1.3 1 0 0 1 1 1 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.21 CCF44179.1 - 0.0032 17.3 1.5 0.037 13.8 1.7 2.6 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain NmrA PF05368.13 CCF44181.1 - 6.4e-23 81.5 0.0 8.7e-23 81.1 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CCF44181.1 - 2.3e-19 70.0 0.3 6.5e-19 68.5 0.3 1.8 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CCF44181.1 - 8.6e-08 31.9 0.1 1.6e-07 31.1 0.1 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 CCF44181.1 - 1.6e-07 31.6 0.3 3.2e-07 30.7 0.0 1.6 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain DapB_N PF01113.20 CCF44181.1 - 6.1e-06 26.4 0.1 1.4e-05 25.2 0.1 1.6 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus RmlD_sub_bind PF04321.17 CCF44181.1 - 1.7e-05 24.0 0.1 3.4e-05 23.1 0.1 1.5 1 0 0 1 1 1 1 RmlD substrate binding domain Semialdhyde_dh PF01118.24 CCF44181.1 - 3.7e-05 24.1 0.2 0.00011 22.7 0.1 1.9 2 0 0 2 2 1 1 Semialdehyde dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 CCF44181.1 - 0.00011 22.3 0.0 0.00019 21.5 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase 3HCDH_N PF02737.18 CCF44181.1 - 0.00035 20.5 0.3 0.00067 19.6 0.3 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DFP PF04127.15 CCF44181.1 - 0.0056 16.5 2.7 0.0077 16.1 0.7 2.1 2 1 1 3 3 3 1 DNA / pantothenate metabolism flavoprotein F420_oxidored PF03807.17 CCF44181.1 - 0.006 17.1 0.3 0.015 15.9 0.3 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 CCF44181.1 - 0.0074 16.5 0.3 0.019 15.1 0.1 1.8 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase 3Beta_HSD PF01073.19 CCF44181.1 - 0.01 14.9 0.1 0.022 13.7 0.0 1.6 2 0 0 2 2 2 0 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 CCF44181.1 - 0.017 14.5 0.1 0.033 13.6 0.1 1.4 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase adh_short PF00106.25 CCF44181.1 - 0.021 14.3 1.5 0.029 13.8 0.4 1.7 2 0 0 2 2 2 0 short chain dehydrogenase 2-Hacid_dh_C PF02826.19 CCF44181.1 - 0.025 13.9 0.1 0.044 13.2 0.1 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GFO_IDH_MocA PF01408.22 CCF44181.1 - 0.11 13.4 0.1 0.32 11.8 0.1 1.7 2 0 0 2 2 2 0 Oxidoreductase family, NAD-binding Rossmann fold K_oxygenase PF13434.6 CCF44181.1 - 0.17 11.0 1.4 1.7 7.7 0.2 2.1 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) Citrate_synt PF00285.21 CCF44182.1 - 1.2e-120 402.9 0.0 1.5e-120 402.5 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain DnaJ-X PF14308.6 CCF44183.1 - 6.9e-80 267.4 2.8 6.9e-80 267.4 2.8 1.5 2 0 0 2 2 2 1 X-domain of DnaJ-containing LtuB PF17455.2 CCF44183.1 - 0.72 10.5 5.6 0.11 13.1 1.0 2.1 2 0 0 2 2 2 0 Late transcription unit B AAR2 PF05282.11 CCF44183.1 - 0.75 9.1 7.3 2.8 7.2 1.0 2.0 1 1 1 2 2 2 0 AAR2 protein Peptidase_S8 PF00082.22 CCF44184.1 - 8.3e-29 100.8 0.7 1.2e-28 100.2 0.7 1.2 1 0 0 1 1 1 1 Subtilase family Kri1_C PF12936.7 CCF44185.1 - 3e-28 97.8 0.0 3e-28 97.8 0.0 4.2 5 1 0 5 5 5 1 KRI1-like family C-terminal Kri1 PF05178.12 CCF44185.1 - 5e-28 97.7 27.6 5e-28 97.7 27.6 5.7 5 3 0 5 5 5 1 KRI1-like family OTCace_N PF02729.21 CCF44187.1 - 3.2e-45 153.8 0.0 4.7e-45 153.2 0.0 1.2 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain OTCace PF00185.24 CCF44187.1 - 4.8e-30 104.7 0.0 8.5e-30 103.9 0.0 1.4 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain Putative_PNPOx PF01243.20 CCF44188.1 - 0.00081 19.5 0.0 0.0016 18.6 0.0 1.5 1 1 1 2 2 2 1 Pyridoxamine 5'-phosphate oxidase VESA1_N PF12785.7 CCF44189.1 - 0.029 13.4 0.7 0.038 13.0 0.7 1.1 1 0 0 1 1 1 0 Variant erythrocyte surface antigen-1 Macoilin PF09726.9 CCF44189.1 - 0.56 8.7 9.2 0.7 8.4 9.2 1.1 1 0 0 1 1 1 0 Macoilin family DUF1635 PF07795.11 CCF44189.1 - 3.4 7.5 4.7 4.8 7.0 4.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) DHHC PF01529.20 CCF44190.1 - 1.1 9.4 6.2 4 7.6 0.5 2.1 2 0 0 2 2 2 0 DHHC palmitoyltransferase Aldo_ket_red PF00248.21 CCF44191.1 - 1.8e-49 168.5 0.0 3.8e-47 160.9 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family Death PF00531.22 CCF44191.1 - 0.011 15.8 0.0 2.5 8.3 0.0 3.4 3 1 1 4 4 4 0 Death domain LysM PF01476.20 CCF44191.1 - 0.033 14.3 0.0 0.075 13.1 0.0 1.6 1 0 0 1 1 1 0 LysM domain COesterase PF00135.28 CCF44192.1 - 3.4e-45 154.9 0.4 2.8e-43 148.6 0.4 2.0 1 1 0 1 1 1 1 Carboxylesterase family DCAF15_WD40 PF14939.6 CCF44192.1 - 0.26 10.9 0.0 0.39 10.3 0.0 1.2 1 0 0 1 1 1 0 DDB1-and CUL4-substrate receptor 15, WD repeat LEF-8 PF04941.12 CCF44192.1 - 0.31 9.2 0.0 0.43 8.8 0.0 1.0 1 0 0 1 1 1 0 Late expression factor 8 (LEF-8) LRR_6 PF13516.6 CCF44193.1 - 2.6e-17 61.3 25.9 0.69 10.1 0.0 12.7 13 0 0 13 13 13 6 Leucine Rich repeat F-box-like PF12937.7 CCF44193.1 - 4.4e-12 45.7 0.8 1.5e-11 44.0 0.8 2.0 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.7 CCF44193.1 - 4e-11 43.0 20.5 0.44 11.0 0.0 7.4 5 2 1 7 7 7 6 Leucine Rich repeats (2 copies) F-box PF00646.33 CCF44193.1 - 6.6e-05 22.7 0.3 6.6e-05 22.7 0.3 2.3 2 0 0 2 2 2 1 F-box domain Methyltransf_17 PF12692.7 CCF44193.1 - 0.17 11.9 0.0 0.36 10.8 0.0 1.6 1 0 0 1 1 1 0 S-adenosyl-L-methionine methyltransferase AAA_11 PF13086.6 CCF44196.1 - 3.3e-12 46.7 0.0 4.8e-12 46.2 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CCF44196.1 - 1.9e-06 27.7 0.0 3.2e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CCF44196.1 - 5.2e-05 23.6 0.0 0.00011 22.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 CCF44196.1 - 0.0041 16.4 0.0 0.012 14.9 0.0 1.7 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_16 PF13191.6 CCF44196.1 - 0.025 15.0 0.0 0.091 13.1 0.0 2.0 1 0 0 1 1 1 0 AAA ATPase domain ResIII PF04851.15 CCF44196.1 - 0.031 14.3 0.0 0.067 13.2 0.0 1.5 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Helicase_RecD PF05127.14 CCF44196.1 - 0.066 13.1 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Helicase HEPN_Apea PF18739.1 CCF44196.1 - 0.068 13.6 1.8 0.22 12.0 0.2 2.5 3 0 0 3 3 3 0 Apea-like HEPN Glyco_hydro_12 PF01670.16 CCF44197.1 - 2.7e-22 79.8 0.5 3.3e-22 79.5 0.5 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 12 NACHT PF05729.12 CCF44198.1 - 4.3e-10 39.8 0.0 6e-10 39.3 0.0 1.2 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 CCF44198.1 - 0.0019 18.6 0.0 0.003 18.0 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.22 CCF44198.1 - 0.0084 15.3 0.1 0.068 12.3 0.0 2.2 2 1 1 3 3 3 1 NB-ARC domain AAA_22 PF13401.6 CCF44198.1 - 0.014 15.7 0.0 0.03 14.6 0.0 1.6 2 0 0 2 2 2 0 AAA domain ECH_2 PF16113.5 CCF44198.1 - 0.052 13.0 0.2 6.8 6.1 0.5 2.0 1 1 1 2 2 2 0 Enoyl-CoA hydratase/isomerase EcoEI_R_C PF08463.10 CCF44198.1 - 0.064 13.4 0.8 0.4 10.8 0.7 2.1 1 1 0 1 1 1 0 EcoEI R protein C-terminal Blt1_C PF17183.4 CCF44198.1 - 0.072 12.7 0.1 0.16 11.6 0.1 1.6 1 0 0 1 1 1 0 Get5 carboxyl domain Interferon PF00143.19 CCF44198.1 - 0.084 13.1 0.3 0.36 11.0 0.1 2.0 2 0 0 2 2 2 0 Interferon alpha/beta domain p450 PF00067.22 CCF44199.1 - 7.7e-62 209.5 0.0 9.1e-62 209.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 zf-C3HC4_5 PF17121.5 CCF44200.1 - 0.018 14.9 1.0 0.041 13.8 1.0 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Apt1 PF10351.9 CCF44202.1 - 0.0017 17.3 1.1 0.002 17.1 1.1 1.1 1 0 0 1 1 1 1 Golgi-body localisation protein domain SR-25 PF10500.9 CCF44202.1 - 0.0083 15.8 10.7 0.013 15.1 10.7 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein DUF5423 PF17461.2 CCF44202.1 - 0.47 9.3 12.6 0.68 8.7 12.6 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5423) CCDC106 PF15794.5 CCF44202.1 - 0.97 9.1 7.8 1.5 8.5 7.8 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Zip PF02535.22 CCF44202.1 - 3.9 6.6 6.0 5.4 6.1 6.0 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter p450 PF00067.22 CCF44203.1 - 1.2e-51 175.9 0.0 1.4e-51 175.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Cutinase PF01083.22 CCF44205.1 - 1.8e-20 73.6 0.1 2.3e-20 73.3 0.1 1.1 1 0 0 1 1 1 1 Cutinase PE-PPE PF08237.11 CCF44205.1 - 0.0021 17.7 0.0 0.003 17.1 0.0 1.2 1 0 0 1 1 1 1 PE-PPE domain PX PF00787.24 CCF44206.1 - 1e-19 70.6 0.0 4.9e-19 68.4 0.0 2.1 2 0 0 2 2 2 1 PX domain Vps5 PF09325.10 CCF44206.1 - 2e-12 47.2 13.5 7.5e-08 32.2 0.7 2.1 2 0 0 2 2 2 2 Vps5 C terminal like DUF2115 PF09888.9 CCF44206.1 - 2.4 8.6 4.5 4.2 7.9 1.0 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2115) TPR_1 PF00515.28 CCF44207.1 - 8.3e-34 114.0 20.4 2.5e-05 23.9 0.8 11.3 11 0 0 11 11 11 8 Tetratricopeptide repeat TPR_2 PF07719.17 CCF44207.1 - 6.1e-29 97.8 33.1 0.00033 20.5 0.7 12.6 13 0 0 13 13 13 8 Tetratricopeptide repeat TPR_8 PF13181.6 CCF44207.1 - 4.1e-26 89.0 29.3 7.4e-05 22.7 0.6 12.4 13 0 0 13 13 12 6 Tetratricopeptide repeat TPR_7 PF13176.6 CCF44207.1 - 4.5e-17 60.7 29.1 0.0002 21.1 0.2 10.7 12 0 0 12 12 11 5 Tetratricopeptide repeat TPR_14 PF13428.6 CCF44207.1 - 4.3e-15 55.1 29.3 0.038 14.8 0.0 13.4 11 3 3 14 14 12 4 Tetratricopeptide repeat TPR_12 PF13424.6 CCF44207.1 - 5.4e-14 52.2 29.7 0.0063 16.8 0.1 10.8 11 2 0 12 12 11 5 Tetratricopeptide repeat TPR_17 PF13431.6 CCF44207.1 - 6.1e-12 45.1 9.5 0.15 12.5 0.0 10.6 13 0 0 13 13 11 3 Tetratricopeptide repeat TPR_19 PF14559.6 CCF44207.1 - 1.6e-11 44.5 29.9 0.0052 17.3 0.0 11.3 10 4 1 12 12 10 3 Tetratricopeptide repeat TPR_11 PF13414.6 CCF44207.1 - 2.2e-11 43.3 13.2 0.0022 17.6 0.0 7.2 8 0 0 8 8 8 3 TPR repeat TPR_6 PF13174.6 CCF44207.1 - 7.3e-09 35.7 21.2 0.037 14.7 0.0 12.1 13 1 0 13 13 12 2 Tetratricopeptide repeat TPR_10 PF13374.6 CCF44207.1 - 1e-08 34.8 16.1 0.025 14.4 0.0 9.3 10 0 0 10 10 9 2 Tetratricopeptide repeat TPR_16 PF13432.6 CCF44207.1 - 2e-08 34.8 28.7 0.0041 17.7 0.0 9.4 10 2 2 12 12 12 3 Tetratricopeptide repeat ANAPC3 PF12895.7 CCF44207.1 - 0.068 13.4 14.9 0.82 9.9 0.7 6.6 7 0 0 7 7 7 0 Anaphase-promoting complex, cyclosome, subunit 3 TFIIA PF03153.13 CCF44207.1 - 2.3 8.1 32.8 5.1 7.0 32.8 1.6 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4810 PF16068.5 CCF44207.1 - 2.4 8.7 10.5 1.4 9.5 0.0 4.9 4 1 0 4 4 3 0 Domain of unknown function (DUF4810) 2OG-FeII_Oxy PF03171.20 CCF44209.1 - 5.5e-15 55.7 0.0 9.6e-15 54.9 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 CCF44209.1 - 6.5e-13 49.5 0.0 1.1e-12 48.7 0.0 1.4 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal TAT_signal PF10518.9 CCF44209.1 - 0.12 12.3 0.5 0.24 11.3 0.5 1.6 1 0 0 1 1 1 0 TAT (twin-arginine translocation) pathway signal sequence Fungal_trans_2 PF11951.8 CCF44210.1 - 0.00016 20.6 0.0 0.0002 20.3 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain RRM_1 PF00076.22 CCF44211.1 - 3.2e-14 52.5 0.0 4.9e-14 51.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Aconitase PF00330.20 CCF44213.1 - 9.2e-160 532.6 0.6 1.2e-159 532.2 0.1 1.4 2 0 0 2 2 2 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 CCF44213.1 - 6.1e-41 139.8 0.0 1.1e-40 139.0 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain MARVEL PF01284.23 CCF44214.1 - 7.3e-16 58.5 19.8 1e-15 58.0 19.8 1.2 1 0 0 1 1 1 1 Membrane-associating domain OCD_Mu_crystall PF02423.15 CCF44215.1 - 1.8e-07 30.4 0.0 2.3e-07 30.1 0.0 1.1 1 0 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family Shikimate_DH PF01488.20 CCF44215.1 - 0.00017 21.6 0.1 0.00027 21.0 0.1 1.2 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase TIG_2 PF18020.1 CCF44215.1 - 0.088 13.4 0.0 0.15 12.7 0.0 1.4 1 0 0 1 1 1 0 TIG domain found in plexin GATase PF00117.28 CCF44216.1 - 1.1e-37 129.7 0.0 4.1e-37 127.8 0.0 1.8 2 0 0 2 2 2 1 Glutamine amidotransferase class-I GMP_synt_C PF00958.22 CCF44216.1 - 2e-35 120.7 0.0 3.7e-35 119.9 0.0 1.4 1 0 0 1 1 1 1 GMP synthase C terminal domain NAD_synthase PF02540.17 CCF44216.1 - 2.8e-08 33.2 0.0 6.5e-06 25.4 0.0 2.2 2 0 0 2 2 2 2 NAD synthase Peptidase_C26 PF07722.13 CCF44216.1 - 1.4e-06 28.3 0.0 2.8e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 Peptidase C26 tRNA_Me_trans PF03054.16 CCF44216.1 - 0.0028 16.5 0.1 0.0064 15.3 0.0 1.6 2 0 0 2 2 2 1 tRNA methyl transferase QueC PF06508.13 CCF44216.1 - 0.0063 16.0 0.0 0.034 13.6 0.0 1.9 2 0 0 2 2 2 1 Queuosine biosynthesis protein QueC ThiI PF02568.14 CCF44216.1 - 0.038 13.6 0.0 0.091 12.3 0.0 1.6 2 0 0 2 2 2 0 Thiamine biosynthesis protein (ThiI) PAPS_reduct PF01507.19 CCF44216.1 - 0.046 13.7 0.0 0.074 13.1 0.0 1.3 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family Arginosuc_synth PF00764.19 CCF44216.1 - 0.058 12.7 0.1 0.096 12.0 0.1 1.3 1 0 0 1 1 1 0 Arginosuccinate synthase ATP_bind_3 PF01171.20 CCF44216.1 - 0.15 11.8 0.0 0.3 10.8 0.0 1.5 1 0 0 1 1 1 0 PP-loop family Mito_carr PF00153.27 CCF44217.1 - 1.9e-44 149.5 5.9 2.1e-19 69.2 0.2 4.1 3 1 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 CCF44217.1 - 0.27 10.4 2.7 0.21 10.7 0.1 1.9 2 0 0 2 2 2 0 Gammaproteobacterial serine protease JAB PF01398.21 CCF44219.1 - 9.2e-07 28.9 1.4 0.00016 21.7 1.4 2.2 1 1 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MFS_1 PF07690.16 CCF44220.1 - 3.6e-31 108.4 23.2 4.5e-31 108.0 23.2 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Alpha-amylase_C PF02806.18 CCF44221.1 - 4.2e-27 94.4 0.1 1.5e-26 92.7 0.1 2.0 2 0 0 2 2 2 1 Alpha amylase, C-terminal all-beta domain CBM_48 PF02922.18 CCF44221.1 - 4.7e-18 65.3 0.2 1.9e-17 63.4 0.0 2.1 2 0 0 2 2 2 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Alpha-amylase PF00128.24 CCF44221.1 - 1.9e-15 57.3 0.3 4.7e-12 46.1 0.1 2.5 1 1 1 2 2 2 2 Alpha amylase, catalytic domain AMPK1_CBM PF16561.5 CCF44221.1 - 0.02 15.1 0.0 0.05 13.8 0.0 1.6 1 0 0 1 1 1 0 Glycogen recognition site of AMP-activated protein kinase hDGE_amylase PF14701.6 CCF44221.1 - 0.067 12.3 0.2 0.24 10.4 0.1 1.8 2 0 0 2 2 2 0 Glycogen debranching enzyme, glucanotransferase domain Cellulase PF00150.18 CCF44221.1 - 0.075 12.4 0.0 0.15 11.5 0.0 1.4 1 0 0 1 1 1 0 Cellulase (glycosyl hydrolase family 5) DUF234 PF03008.14 CCF44223.1 - 0.061 13.8 0.5 0.37 11.3 0.3 2.0 2 0 0 2 2 2 0 Archaea bacterial proteins of unknown function Raptor_N PF14538.6 CCF44224.1 - 1.3e-65 219.9 0.0 2e-65 219.2 0.0 1.3 1 0 0 1 1 1 1 Raptor N-terminal CASPase like domain Condensation PF00668.20 CCF44227.1 - 1.6e-26 93.0 0.0 1e-23 83.7 0.0 3.2 2 1 0 2 2 2 2 Condensation domain Ion_trans PF00520.31 CCF44228.1 - 0.12 11.6 16.1 0.41 9.8 16.1 1.9 1 1 1 2 2 2 0 Ion transport protein MFS_1 PF07690.16 CCF44231.1 - 1.6e-30 106.3 30.1 2.5e-30 105.6 30.1 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily TMEM100 PF16311.5 CCF44231.1 - 0.078 12.6 0.5 2.5 7.7 0.3 2.3 2 0 0 2 2 2 0 Transmembrane protein 100 PsbN PF02468.15 CCF44231.1 - 3.2 7.7 6.4 0.6 10.0 1.0 2.4 2 0 0 2 2 2 0 Photosystem II reaction centre N protein (psbN) Peptidase_M28 PF04389.17 CCF44233.1 - 5.6e-20 71.9 0.0 9.1e-20 71.2 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 CCF44233.1 - 1e-10 41.4 0.3 1.4e-09 37.8 0.3 2.5 1 1 0 1 1 1 1 PA domain Peptidase_M20 PF01546.28 CCF44233.1 - 0.034 13.8 0.0 0.06 13.0 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M20/M25/M40 HTH_psq PF05225.16 CCF44234.1 - 1.2e-11 44.1 0.1 2.4e-11 43.2 0.1 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.16 CCF44234.1 - 2.8e-11 43.3 0.2 1.4e-10 41.0 0.0 2.1 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_23 PF13384.6 CCF44234.1 - 0.00019 21.2 0.1 0.00052 19.7 0.1 1.8 1 0 0 1 1 1 1 Homeodomain-like domain HTH_7 PF02796.15 CCF44234.1 - 0.001 19.1 0.1 0.0021 18.1 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_30 PF13556.6 CCF44234.1 - 0.0031 17.3 0.1 0.0074 16.1 0.1 1.6 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain HTH_28 PF13518.6 CCF44234.1 - 0.0056 16.8 0.2 0.02 15.0 0.1 2.1 1 1 0 1 1 1 1 Helix-turn-helix domain HTH_Tnp_1 PF01527.20 CCF44234.1 - 0.023 15.0 0.3 0.054 13.8 0.1 1.8 1 1 0 1 1 1 0 Transposase HTH_1 PF00126.27 CCF44234.1 - 0.053 13.5 0.8 0.11 12.5 0.8 1.5 1 0 0 1 1 1 0 Bacterial regulatory helix-turn-helix protein, lysR family CENP-B_N PF04218.13 CCF44234.1 - 0.09 12.4 0.0 0.21 11.2 0.0 1.6 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain NAD_binding_6 PF08030.12 CCF44235.1 - 5.7e-19 68.8 0.0 1.5e-16 60.9 0.0 2.3 1 1 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 CCF44235.1 - 1.9e-08 34.3 0.0 0.00035 20.6 0.0 2.4 1 1 1 2 2 2 2 FAD-binding domain Abhydrolase_6 PF12697.7 CCF44236.1 - 3.6e-05 24.5 7.9 3.6e-05 24.5 7.9 2.0 2 1 0 2 2 2 1 Alpha/beta hydrolase family DUF1100 PF06500.11 CCF44236.1 - 8.1e-05 21.6 0.0 0.00011 21.1 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1100) Abhydrolase_1 PF00561.20 CCF44236.1 - 0.00086 19.0 0.0 0.002 17.8 0.1 1.5 2 0 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CCF44236.1 - 0.018 14.5 0.1 0.037 13.5 0.0 1.6 2 0 0 2 2 2 0 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 CCF44236.1 - 0.022 14.0 0.0 0.058 12.6 0.0 1.7 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 CCF44236.1 - 0.032 14.1 0.1 0.059 13.2 0.1 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold AXE1 PF05448.12 CCF44236.1 - 0.047 12.4 0.0 0.084 11.5 0.0 1.3 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) adh_short PF00106.25 CCF44237.1 - 1.6e-10 40.8 0.0 1.9e-10 40.6 0.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF44237.1 - 4.1e-07 30.1 0.0 5.1e-07 29.8 0.0 1.0 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.6 CCF44237.1 - 0.00019 21.1 0.0 0.00023 20.8 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Eno-Rase_NADH_b PF12242.8 CCF44237.1 - 0.093 12.5 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Glyco_transf_8 PF01501.20 CCF44239.1 - 1.5e-09 37.8 0.0 6.8e-08 32.4 0.0 2.0 1 1 0 1 1 1 1 Glycosyl transferase family 8 Mannosyl_trans3 PF11051.8 CCF44239.1 - 0.0037 16.7 0.0 0.0056 16.1 0.0 1.1 1 0 0 1 1 1 1 Mannosyltransferase putative Nucleotid_trans PF03407.16 CCF44239.1 - 0.096 12.7 0.0 0.13 12.2 0.0 1.2 1 0 0 1 1 1 0 Nucleotide-diphospho-sugar transferase SPC12 PF06645.13 CCF44240.1 - 0.12 12.5 0.8 0.23 11.6 0.8 1.3 1 0 0 1 1 1 0 Microsomal signal peptidase 12 kDa subunit (SPC12) LOH1CR12 PF10158.9 CCF44240.1 - 0.14 12.2 1.0 0.93 9.5 0.3 2.1 2 0 0 2 2 2 0 Tumour suppressor protein DUF848 PF05852.11 CCF44240.1 - 0.29 11.3 2.0 1.5 8.9 0.2 2.7 2 1 1 3 3 3 0 Gammaherpesvirus protein of unknown function (DUF848) Oxysterol_BP PF01237.18 CCF44241.1 - 3e-109 365.3 0.0 6.4e-109 364.2 0.0 1.6 1 1 0 1 1 1 1 Oxysterol-binding protein PH_8 PF15409.6 CCF44241.1 - 9e-39 131.7 1.0 3e-38 130.0 0.1 2.2 2 0 0 2 2 2 1 Pleckstrin homology domain PH PF00169.29 CCF44241.1 - 2.8e-07 31.0 0.0 7.6e-07 29.6 0.0 1.8 1 0 0 1 1 1 1 PH domain gpW PF02831.15 CCF44241.1 - 0.015 15.2 0.0 0.087 12.7 0.0 2.3 2 0 0 2 2 2 0 gpW Zn_clus PF00172.18 CCF44243.1 - 7.3e-08 32.4 9.8 1.3e-07 31.6 9.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 CCF44243.1 - 2.9e-07 29.6 0.3 4.1e-07 29.2 0.3 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain OrfA PF17495.2 CCF44243.1 - 0.16 12.2 0.5 0.56 10.4 0.2 2.0 2 0 0 2 2 2 0 Vpr-like OrfA RTA1 PF04479.13 CCF44246.1 - 2.8e-37 128.3 4.7 2.8e-37 128.3 4.7 1.8 2 1 0 2 2 2 1 RTA1 like protein DUF3493 PF11998.8 CCF44246.1 - 0.68 10.1 4.9 1.5 9.1 3.5 2.1 1 1 1 2 2 2 0 Low psii accumulation1 / Rep27 ADH_N PF08240.12 CCF44247.1 - 5.3e-21 74.6 0.2 8.3e-21 73.9 0.2 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain IGFBP PF00219.18 CCF44247.1 - 0.014 16.0 0.3 0.026 15.1 0.3 1.4 1 0 0 1 1 1 0 Insulin-like growth factor binding protein FAD_oxidored PF12831.7 CCF44248.1 - 1.2e-51 176.4 0.0 1.5e-51 176.1 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.22 CCF44248.1 - 0.0047 16.1 0.1 0.006 15.7 0.1 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A Trp_halogenase PF04820.14 CCF44248.1 - 0.013 14.4 0.0 0.017 14.0 0.0 1.1 1 0 0 1 1 1 0 Tryptophan halogenase Pyr_redox_2 PF07992.14 CCF44248.1 - 0.12 11.6 0.2 0.22 10.7 0.1 1.4 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CCF44248.1 - 0.18 10.5 0.0 0.23 10.1 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein Phe_hydrox_dim PF07976.12 CCF44250.1 - 1.7e-50 171.3 0.0 2e-50 171.0 0.0 1.1 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain PTPLA PF04387.14 CCF44251.1 - 4.4e-50 169.6 10.6 7.5e-50 168.9 10.6 1.4 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA Glyco_tranf_2_3 PF13641.6 CCF44252.1 - 1.9e-22 80.3 0.0 2.6e-22 79.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 CCF44252.1 - 1.7e-05 24.4 0.0 4.2e-05 23.1 0.0 1.7 1 1 0 1 1 1 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 CCF44252.1 - 0.0015 18.3 0.0 0.0053 16.6 0.0 1.9 2 0 0 2 2 2 1 Glycosyl transferase family 2 PTS_2-RNA PF01885.16 CCF44253.1 - 8.5e-36 123.7 0.0 9.9e-36 123.5 0.0 1.1 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family dsrm PF00035.26 CCF44254.1 - 0.15 12.8 0.6 0.56 11.0 0.0 2.3 3 0 0 3 3 3 0 Double-stranded RNA binding motif Ndc1_Nup PF09531.10 CCF44254.1 - 0.16 10.6 3.1 0.21 10.2 3.1 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SPX PF03105.19 CCF44254.1 - 1 9.2 8.9 1.4 8.8 8.9 1.2 1 0 0 1 1 1 0 SPX domain SOG2 PF10428.9 CCF44254.1 - 4 6.5 17.2 5.2 6.1 17.2 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein Fib_alpha PF08702.10 CCF44255.1 - 0.018 15.2 0.1 0.018 15.2 0.1 6.1 2 2 3 6 6 6 0 Fibrinogen alpha/beta chain family SRP54 PF00448.22 CCF44256.1 - 2.2e-53 180.8 0.1 3.9e-53 180.0 0.1 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP-alpha_N PF04086.13 CCF44256.1 - 3e-10 40.5 2.3 4.5e-10 39.9 2.3 1.3 1 0 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal SRP54_N PF02881.19 CCF44256.1 - 8.5e-09 35.5 0.1 1.8e-08 34.5 0.1 1.5 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain MeaB PF03308.16 CCF44256.1 - 7.7e-06 25.1 0.0 1.6e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_30 PF13604.6 CCF44256.1 - 0.00038 20.2 0.1 0.00099 18.9 0.1 1.7 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 CCF44256.1 - 0.00054 20.4 0.4 0.0025 18.2 0.1 2.1 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 CCF44256.1 - 0.0013 18.3 0.1 0.0022 17.6 0.1 1.3 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_25 PF13481.6 CCF44256.1 - 0.0031 17.1 0.1 0.01 15.4 0.0 1.9 1 1 0 1 1 1 1 AAA domain CbiA PF01656.23 CCF44256.1 - 0.0057 16.7 0.6 1.1 9.3 0.1 2.6 3 0 0 3 3 3 1 CobQ/CobB/MinD/ParA nucleotide binding domain MMR_HSR1 PF01926.23 CCF44256.1 - 0.011 15.8 0.3 0.059 13.4 0.3 2.1 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_33 PF13671.6 CCF44256.1 - 0.015 15.4 0.0 0.041 14.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain SMC_N PF02463.19 CCF44256.1 - 0.039 13.4 0.0 0.064 12.7 0.0 1.3 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_24 PF13479.6 CCF44256.1 - 0.043 13.5 0.2 0.13 12.0 0.0 1.8 2 1 0 2 2 2 0 AAA domain ABC_tran PF00005.27 CCF44256.1 - 0.047 14.2 1.3 0.14 12.6 0.1 2.3 2 2 0 2 2 2 0 ABC transporter APS_kinase PF01583.20 CCF44256.1 - 0.075 12.9 0.0 0.21 11.5 0.0 1.7 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_31 PF13614.6 CCF44256.1 - 0.077 12.9 0.1 0.61 10.0 0.1 2.2 1 1 1 2 2 2 0 AAA domain Zeta_toxin PF06414.12 CCF44256.1 - 0.08 12.2 0.0 0.55 9.5 0.0 2.2 1 1 0 1 1 1 0 Zeta toxin zf-LYAR PF08790.11 CCF44258.1 - 0.18 11.7 1.2 0.49 10.3 0.1 2.0 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger Surp PF01805.20 CCF44260.1 - 2.5e-10 40.2 0.0 6e-10 39.0 0.0 1.7 1 0 0 1 1 1 1 Surp module NUDIX PF00293.28 CCF44262.1 - 5.9e-08 32.8 0.0 6.9e-08 32.6 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain Git3 PF11710.8 CCF44263.1 - 2.4e-08 34.0 2.9 2.9e-08 33.7 2.9 1.1 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 Dicty_CAR PF05462.11 CCF44263.1 - 9.9e-05 21.6 3.8 0.00015 21.0 3.8 1.3 1 1 0 1 1 1 1 Slime mold cyclic AMP receptor GDPD PF03009.17 CCF44264.1 - 2.2e-12 47.2 0.0 2.6e-12 47.1 0.0 1.1 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family DUF2782 PF11191.8 CCF44264.1 - 0.056 13.6 0.1 7.6 6.8 0.0 3.3 3 1 0 3 3 3 0 Protein of unknown function (DUF2782) Amidohydro_1 PF01979.20 CCF44265.1 - 1.3e-16 60.9 0.0 1.8e-16 60.4 0.0 1.3 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 CCF44265.1 - 8.3e-11 42.0 0.0 1.8e-09 37.6 0.0 2.0 2 0 0 2 2 2 1 Amidohydrolase family AAA_33 PF13671.6 CCF44265.1 - 0.16 12.2 0.1 0.3 11.3 0.1 1.4 1 0 0 1 1 1 0 AAA domain Pkinase PF00069.25 CCF44267.1 - 3.9e-07 29.7 0.0 5.1e-07 29.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain DHDPS PF00701.22 CCF44270.1 - 8.7e-33 113.3 0.0 1e-32 113.1 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family PHO4 PF01384.20 CCF44272.1 - 5.3e-25 88.2 3.1 6.2e-25 87.9 3.1 1.0 1 0 0 1 1 1 1 Phosphate transporter family UPF0444 PF15475.6 CCF44272.1 - 0.29 11.4 4.2 0.12 12.6 1.8 1.7 1 1 1 2 2 2 0 Transmembrane protein C12orf23, UPF0444 Cu-oxidase PF00394.22 CCF44273.1 - 5.6e-33 114.3 0.1 7.1e-32 110.7 0.1 2.0 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase_3 PF07732.15 CCF44273.1 - 1.5e-29 102.4 0.0 1.3e-28 99.3 0.0 2.0 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 CCF44273.1 - 0.0098 15.6 0.3 0.12 12.1 0.1 2.6 2 2 0 2 2 2 1 Multicopper oxidase SNF2_N PF00176.23 CCF44275.1 - 5.9e-45 153.5 0.0 1.1e-44 152.7 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CCF44275.1 - 2.3e-24 85.9 0.1 1.7e-23 83.1 0.1 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCF44275.1 - 3.5e-05 23.9 0.0 0.00029 20.9 0.0 2.6 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 CCF44275.1 - 0.00027 20.3 0.3 0.00027 20.3 0.3 2.0 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase DUF2201_N PF13203.6 CCF44275.1 - 9.6 5.7 8.9 0.39 10.3 2.4 2.0 2 0 0 2 2 2 0 Putative metallopeptidase domain GSH_synth_ATP PF03917.17 CCF44276.1 - 1.8e-136 454.8 0.0 2.1e-136 454.6 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.15 CCF44276.1 - 1.1e-31 109.3 0.0 2.1e-31 108.4 0.0 1.5 1 0 0 1 1 1 1 Eukaryotic glutathione synthase SSB PF00436.25 CCF44277.1 - 7.3e-20 71.0 0.0 8.8e-20 70.7 0.0 1.1 1 0 0 1 1 1 1 Single-strand binding protein family HeLo PF14479.6 CCF44279.1 - 3.2e-14 53.2 0.8 5e-14 52.6 0.0 1.8 2 0 0 2 2 2 1 Prion-inhibition and propagation NACHT PF05729.12 CCF44279.1 - 4.7e-11 42.9 0.0 9.7e-11 41.9 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 CCF44279.1 - 0.0063 16.8 0.0 0.014 15.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CCF44279.1 - 0.018 15.5 0.1 0.054 13.9 0.0 2.0 2 1 0 2 2 2 0 AAA ATPase domain AAA PF00004.29 CCF44279.1 - 0.018 15.5 0.0 0.041 14.3 0.0 1.5 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 CCF44279.1 - 0.12 12.8 0.0 0.3 11.5 0.0 1.7 1 0 0 1 1 1 0 RNA helicase Vac14_Fig4_bd PF11916.8 CCF44281.1 - 6.7e-82 273.5 8.5 6.7e-82 273.5 8.5 1.6 2 0 0 2 2 2 1 Vacuolar protein 14 C-terminal Fig4p binding Cnd1 PF12717.7 CCF44281.1 - 0.0027 17.7 0.3 0.0051 16.9 0.3 1.4 1 0 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 DUF3450 PF11932.8 CCF44282.1 - 0.00058 19.2 2.0 0.00065 19.1 0.8 1.6 1 1 1 2 2 2 1 Protein of unknown function (DUF3450) TMF_TATA_bd PF12325.8 CCF44282.1 - 0.0045 17.2 2.4 0.13 12.5 0.1 2.3 1 1 1 2 2 2 1 TATA element modulatory factor 1 TATA binding DUF4051 PF13260.6 CCF44282.1 - 0.025 14.3 0.7 0.05 13.4 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4051) Takusan PF04822.13 CCF44282.1 - 0.026 14.4 0.8 4.3 7.3 0.0 2.3 2 0 0 2 2 2 0 Takusan COG2 PF06148.11 CCF44282.1 - 0.03 14.4 1.2 0.16 12.1 0.1 2.0 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 CENP-F_leu_zip PF10473.9 CCF44282.1 - 0.066 13.2 2.9 5.2 7.1 0.7 2.2 1 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Lectin_N PF03954.14 CCF44282.1 - 0.069 12.9 0.1 0.36 10.6 0.1 1.9 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain DUF349 PF03993.12 CCF44282.1 - 0.081 13.2 0.7 0.15 12.3 0.3 1.7 1 1 1 2 2 2 0 Domain of Unknown Function (DUF349) PspB PF06667.12 CCF44282.1 - 0.18 11.9 3.4 2.7 8.1 0.0 3.0 2 1 1 3 3 3 0 Phage shock protein B FUSC PF04632.12 CCF44282.1 - 1.8 7.0 5.1 2.1 6.8 5.1 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family BBE PF08031.12 CCF44283.1 - 9.4e-08 32.0 0.2 2e-07 31.0 0.2 1.5 1 0 0 1 1 1 1 Berberine and berberine like Cytokin-bind PF09265.10 CCF44283.1 - 0.14 11.5 0.4 0.2 11.0 0.4 1.1 1 0 0 1 1 1 0 Cytokinin dehydrogenase 1, FAD and cytokinin binding Ank_2 PF12796.7 CCF44284.1 - 1.3e-14 54.5 0.0 5e-13 49.4 0.0 2.2 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CCF44284.1 - 2e-13 50.5 0.3 1.1e-06 29.1 0.0 3.0 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCF44284.1 - 6.3e-13 47.7 0.0 6.6e-05 23.0 0.0 4.3 4 1 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 CCF44284.1 - 9.5e-13 48.0 0.0 0.0024 18.3 0.0 4.1 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 CCF44284.1 - 1.3e-12 47.7 0.0 6.7e-07 29.5 0.0 2.9 2 1 1 3 3 3 2 Ankyrin repeats (many copies) TPR_12 PF13424.6 CCF44285.1 - 0.0018 18.5 6.2 1.3 9.4 0.6 4.5 4 1 1 5 5 5 3 Tetratricopeptide repeat Methyltransf_2 PF00891.18 CCF44287.1 - 0.12 11.6 0.1 0.16 11.2 0.1 1.2 1 0 0 1 1 1 0 O-methyltransferase domain Sugar_tr PF00083.24 CCF44288.1 - 1.2e-106 357.3 23.5 1.4e-106 357.1 23.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF44288.1 - 4.7e-26 91.6 30.0 4e-24 85.2 13.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 CCF44288.1 - 0.0057 15.0 1.1 0.0057 15.0 1.1 2.8 2 1 1 3 3 3 2 Organic Anion Transporter Polypeptide (OATP) family YbhQ PF11076.8 CCF44288.1 - 0.026 14.5 0.1 0.057 13.4 0.1 1.6 1 0 0 1 1 1 0 Putative inner membrane protein YbhQ MFS_1 PF07690.16 CCF44289.1 - 9e-19 67.6 6.7 9e-19 67.6 6.7 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF44289.1 - 2.1e-09 36.8 1.4 3.2e-09 36.2 1.4 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter DUF5326 PF17260.2 CCF44289.1 - 0.0085 16.2 2.8 0.023 14.8 0.4 2.4 2 0 0 2 2 2 1 Family of unknown function (DUF5326) TRI12 PF06609.13 CCF44289.1 - 0.048 12.1 0.4 0.06 11.8 0.4 1.1 1 0 0 1 1 1 0 Fungal trichothecene efflux pump (TRI12) COX7a PF02238.15 CCF44289.1 - 5.2 7.6 7.5 0.83 10.1 0.4 2.6 2 0 0 2 2 2 0 Cytochrome c oxidase subunit VII Transp_cyt_pur PF02133.15 CCF44290.1 - 5.7e-29 101.2 15.4 7.1e-29 100.8 15.4 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Zn_clus PF00172.18 CCF44291.1 - 6.3e-09 35.8 12.4 9.5e-09 35.2 12.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FXR_C1 PF16096.5 CCF44291.1 - 0.043 14.0 0.2 0.043 14.0 0.2 2.0 3 0 0 3 3 3 0 Fragile X-related 1 protein C-terminal region 2 Mito_carr PF00153.27 CCF44292.1 - 7.5e-06 25.8 0.2 2.3e-05 24.2 0.2 1.7 1 1 0 1 1 1 1 Mitochondrial carrier protein Serine_protease PF18405.1 CCF44292.1 - 0.00036 19.8 0.1 0.00039 19.7 0.1 1.0 1 0 0 1 1 1 1 Gammaproteobacterial serine protease Deltameth_res PF16020.5 CCF44292.1 - 0.13 12.2 1.6 0.3 11.0 0.1 1.9 1 1 1 2 2 2 0 Deltamethrin resistance ATP-synt_C PF00137.21 CCF44294.1 - 2.4e-29 101.5 33.1 3.2e-18 65.8 10.2 2.1 2 0 0 2 2 2 2 ATP synthase subunit C Glyco_hydro_12 PF01670.16 CCF44295.1 - 1.4e-47 162.5 10.0 1.5e-47 162.3 10.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 12 Bac_luciferase PF00296.20 CCF44296.1 - 3.7e-60 204.0 0.1 5e-60 203.6 0.1 1.1 1 0 0 1 1 1 1 Luciferase-like monooxygenase MFS_1 PF07690.16 CCF44297.1 - 3.9e-28 98.4 29.1 5.8e-28 97.8 29.1 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily FMO-like PF00743.19 CCF44298.1 - 2.7e-13 49.2 0.0 9.7e-13 47.4 0.0 1.9 2 1 0 2 2 2 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 CCF44298.1 - 9.5e-11 41.8 0.0 4.5e-10 39.6 0.0 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CCF44298.1 - 2.5e-07 30.2 0.0 7.6e-06 25.4 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCF44298.1 - 5.3e-07 29.2 0.0 3.7e-06 26.4 0.0 2.4 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CCF44298.1 - 5.2e-05 22.5 0.0 0.003 16.7 0.0 2.7 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.17 CCF44298.1 - 0.0013 18.0 0.2 0.0045 16.3 0.1 1.8 2 0 0 2 2 2 1 Thi4 family NAD_binding_9 PF13454.6 CCF44298.1 - 0.0014 18.6 0.5 0.54 10.2 0.0 3.5 3 1 0 3 3 3 1 FAD-NAD(P)-binding DAO PF01266.24 CCF44298.1 - 0.031 13.9 0.1 7.9 5.9 0.1 2.6 2 1 0 2 2 2 0 FAD dependent oxidoreductase OmdA PF13376.6 CCF44298.1 - 0.099 12.7 0.8 1.4 9.0 0.2 2.8 3 0 0 3 3 3 0 Bacteriocin-protection, YdeI or OmpD-Associated Acyl_transf_1 PF00698.21 CCF44299.1 - 2.4e-48 165.3 0.0 9.2e-48 163.4 0.0 2.0 2 0 0 2 2 2 1 Acyl transferase domain KR PF08659.10 CCF44299.1 - 1e-45 155.8 0.1 4.2e-45 153.9 0.0 2.1 2 0 0 2 2 2 1 KR domain PS-DH PF14765.6 CCF44299.1 - 8.1e-27 94.2 0.0 2.3e-26 92.7 0.0 1.6 1 1 0 1 1 1 1 Polyketide synthase dehydratase Methyltransf_12 PF08242.12 CCF44299.1 - 2.5e-21 76.3 0.0 7.5e-21 74.7 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain KAsynt_C_assoc PF16197.5 CCF44299.1 - 1.6e-18 67.2 0.0 4.6e-18 65.7 0.0 1.8 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Methyltransf_25 PF13649.6 CCF44299.1 - 5.4e-14 52.7 0.0 3e-13 50.3 0.0 2.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF44299.1 - 1.4e-11 44.5 0.0 3.6e-11 43.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF44299.1 - 2.5e-11 44.1 0.0 7.4e-11 42.6 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF44299.1 - 4.4e-10 39.5 0.0 9.4e-10 38.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain adh_short PF00106.25 CCF44299.1 - 6.4e-09 35.5 0.0 1.7e-08 34.2 0.0 1.7 1 0 0 1 1 1 1 short chain dehydrogenase Ubie_methyltran PF01209.18 CCF44299.1 - 3.9e-07 29.7 0.0 7.4e-07 28.7 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family adh_short_C2 PF13561.6 CCF44299.1 - 1.3e-06 28.2 0.0 2.8e-06 27.1 0.0 1.5 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase PP-binding PF00550.25 CCF44299.1 - 1.4e-06 28.5 0.1 3.8e-06 27.2 0.1 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site Ketoacyl-synt_C PF02801.22 CCF44299.1 - 6.7e-05 22.9 0.3 0.00021 21.3 0.2 2.0 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Methyltransf_16 PF10294.9 CCF44299.1 - 0.00065 19.5 0.0 0.0013 18.5 0.0 1.4 1 0 0 1 1 1 1 Lysine methyltransferase SAT PF16073.5 CCF44299.1 - 0.007 16.1 0.0 0.025 14.3 0.0 2.0 2 0 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis NodS PF05401.11 CCF44299.1 - 0.014 15.0 0.0 0.046 13.3 0.0 1.8 1 0 0 1 1 1 0 Nodulation protein S (NodS) p450 PF00067.22 CCF44300.1 - 7.7e-64 216.1 0.0 8.8e-64 215.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 KR PF08659.10 CCF44301.1 - 9.7e-62 208.1 0.0 2.5e-61 206.7 0.0 1.8 1 0 0 1 1 1 1 KR domain ketoacyl-synt PF00109.26 CCF44301.1 - 3.6e-52 177.4 2.4 4e-52 177.3 0.7 1.9 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 CCF44301.1 - 5.2e-51 174.0 0.0 8.9e-51 173.3 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain PS-DH PF14765.6 CCF44301.1 - 2.1e-47 161.8 0.2 3.5e-47 161.1 0.2 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase Ketoacyl-synt_C PF02801.22 CCF44301.1 - 2.5e-35 121.0 0.0 6.2e-35 119.8 0.0 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 CCF44301.1 - 4.3e-15 56.1 0.0 1.3e-14 54.6 0.0 1.9 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension PP-binding PF00550.25 CCF44301.1 - 2.2e-06 27.9 0.1 8.5e-06 26.0 0.1 2.1 1 0 0 1 1 1 1 Phosphopantetheine attachment site Thiolase_N PF00108.23 CCF44301.1 - 9.6e-06 25.1 0.0 2e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain adh_short PF00106.25 CCF44301.1 - 4e-05 23.2 0.0 0.00011 21.8 0.0 1.6 1 0 0 1 1 1 1 short chain dehydrogenase ACP_syn_III PF08545.10 CCF44301.1 - 0.00082 19.2 0.1 0.0035 17.1 0.1 2.1 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III SAT PF16073.5 CCF44301.1 - 0.0015 18.3 1.0 0.0052 16.6 1.0 1.9 1 0 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis adh_short_C2 PF13561.6 CCF44301.1 - 0.012 15.2 0.0 0.029 13.9 0.0 1.6 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase RabGAP-TBC PF00566.18 CCF44303.1 - 2.1e-20 73.3 0.0 3.6e-20 72.6 0.0 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Nop14 PF04147.12 CCF44303.1 - 0.16 10.1 8.8 0.22 9.7 8.8 1.1 1 0 0 1 1 1 0 Nop14-like family POX PF07526.11 CCF44303.1 - 1.5 9.4 4.6 3.1 8.4 4.6 1.5 1 0 0 1 1 1 0 Associated with HOX Y_phosphatase2 PF03162.13 CCF44307.1 - 2.2e-44 151.0 0.0 3.3e-44 150.4 0.0 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 CCF44307.1 - 2.8e-10 40.6 0.0 6.5e-10 39.4 0.0 1.6 1 1 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 CCF44307.1 - 0.0081 15.7 0.0 0.012 15.2 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 CCF44307.1 - 0.018 14.9 0.0 0.028 14.2 0.0 1.4 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain COesterase PF00135.28 CCF44309.1 - 2.6e-91 307.0 0.0 3.4e-91 306.6 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CCF44309.1 - 3.6e-05 23.7 0.0 8.5e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CCF44309.1 - 0.0077 15.7 0.0 0.014 14.9 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_M61 PF05299.12 CCF44310.1 - 0.0011 19.4 0.2 0.014 15.8 0.2 2.2 1 1 0 1 1 1 1 M61 glycyl aminopeptidase BSP PF04450.12 CCF44310.1 - 0.0042 16.9 0.0 0.0071 16.2 0.0 1.2 1 0 0 1 1 1 1 Peptidase of plants and bacteria RasGAP PF00616.19 CCF44312.1 - 1e-59 201.8 0.3 1.7e-59 201.0 0.0 1.6 2 0 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.15 CCF44312.1 - 2.6e-29 102.1 6.8 6.6e-29 100.8 6.8 1.7 1 0 0 1 1 1 1 RasGAP C-terminus AAA_lid_10 PF17872.1 CCF44313.1 - 5.3e-12 45.7 0.1 1.2e-11 44.6 0.1 1.6 1 0 0 1 1 1 1 AAA lid domain AAA_assoc_2 PF16193.5 CCF44313.1 - 0.099 13.0 0.1 0.26 11.6 0.1 1.7 1 0 0 1 1 1 0 AAA C-terminal domain WD40 PF00400.32 CCF44314.1 - 9.8e-45 149.7 17.6 6.7e-09 36.2 0.3 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF44314.1 - 5.9e-05 23.3 0.2 15 6.0 0.0 5.0 1 1 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CCF44314.1 - 0.019 13.6 2.4 12 4.4 0.0 4.2 1 1 4 5 5 5 0 Nucleoporin Nup120/160 Tfb4 PF03850.14 CCF44315.1 - 7.5e-59 199.5 0.6 9.3e-59 199.2 0.6 1.0 1 0 0 1 1 1 1 Transcription factor Tfb4 Cation_efflux PF01545.21 CCF44316.1 - 5.9e-15 55.5 10.6 7.3e-15 55.2 10.6 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 CCF44316.1 - 1.2e-11 44.5 1.2 3.3e-11 43.2 1.2 1.7 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter FdhE PF04216.12 CCF44316.1 - 0.082 12.8 0.0 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein involved in formate dehydrogenase formation PDR_CDR PF06422.12 CCF44317.1 - 0.0031 17.4 0.4 0.0041 17.0 0.4 1.3 1 0 0 1 1 1 1 CDR ABC transporter Methyltransf_23 PF13489.6 CCF44318.1 - 1.2e-11 44.7 0.1 1.8e-11 44.1 0.1 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF44318.1 - 4.7e-06 27.3 0.0 7.1e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF44318.1 - 1e-05 26.1 0.0 1.7e-05 25.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF44318.1 - 0.0024 18.5 0.0 0.0038 17.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF44318.1 - 0.0068 16.2 0.0 0.0086 15.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain GPI-anchored PF10342.9 CCF44319.1 - 1.3e-15 57.9 1.1 3.1e-15 56.7 1.1 1.6 1 0 0 1 1 1 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Cupredoxin_1 PF13473.6 CCF44319.1 - 0.096 12.8 0.0 0.24 11.5 0.0 1.7 1 1 0 1 1 1 0 Cupredoxin-like domain Macoilin PF09726.9 CCF44319.1 - 0.61 8.6 4.2 0.71 8.4 4.2 1.0 1 0 0 1 1 1 0 Macoilin family 2-oxoacid_dh PF00198.23 CCF44321.1 - 2.2e-37 128.8 0.0 2.3e-37 128.7 0.0 1.0 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) HLH PF00010.26 CCF44322.1 - 3.9e-15 55.5 1.5 1.4e-14 53.7 1.5 2.0 1 1 0 1 1 1 1 Helix-loop-helix DNA-binding domain Pcc1 PF09341.10 CCF44323.1 - 1.1e-32 112.0 0.9 1.3e-32 111.7 0.9 1.1 1 0 0 1 1 1 1 Transcription factor Pcc1 DSPn PF14671.6 CCF44324.1 - 8.6e-42 142.9 0.0 1.4e-39 135.8 0.0 2.5 2 1 0 2 2 2 2 Dual specificity protein phosphatase, N-terminal half DSPc PF00782.20 CCF44324.1 - 4.1e-16 59.0 0.0 8.2e-16 58.0 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 CCF44324.1 - 4.7e-06 26.4 0.0 1e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DUF3405 PF11885.8 CCF44325.1 - 7.5e-169 562.6 0.2 8.5e-169 562.5 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3405) TcpQ PF10671.9 CCF44325.1 - 0.013 15.6 0.1 0.031 14.4 0.1 1.6 1 0 0 1 1 1 0 Toxin co-regulated pilus biosynthesis protein Q AMPK1_CBM PF16561.5 CCF44326.1 - 3.3e-08 33.6 0.0 7.3e-08 32.5 0.0 1.6 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase HAMP PF00672.25 CCF44326.1 - 0.049 14.0 0.7 8.2 6.9 0.1 2.5 2 0 0 2 2 2 0 HAMP domain MIP PF00230.20 CCF44327.1 - 1.9e-40 139.0 9.2 2.1e-40 138.8 9.2 1.0 1 0 0 1 1 1 1 Major intrinsic protein HPP PF04982.13 CCF44328.1 - 1.1e-38 132.2 6.8 1.1e-38 132.2 6.8 1.7 2 0 0 2 2 2 1 HPP family DUF3377 PF11857.8 CCF44328.1 - 0.019 14.8 2.4 0.059 13.3 2.4 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) Bax1-I PF01027.20 CCF44328.1 - 4 7.2 8.8 5.1 6.9 3.4 2.2 1 1 1 2 2 2 0 Inhibitor of apoptosis-promoting Bax1 PAF-AH_p_II PF03403.13 CCF44330.1 - 1.8e-35 122.2 0.0 2.6e-35 121.7 0.0 1.2 1 0 0 1 1 1 1 Platelet-activating factor acetylhydrolase, isoform II Hydrolase_4 PF12146.8 CCF44330.1 - 0.0021 17.4 1.2 0.077 12.3 0.0 2.6 2 1 1 3 3 3 1 Serine aminopeptidase, S33 Chlorophyllase2 PF12740.7 CCF44330.1 - 0.0023 16.9 0.0 0.029 13.3 0.0 2.1 1 1 0 1 1 1 1 Chlorophyllase enzyme Abhydrolase_6 PF12697.7 CCF44330.1 - 0.0045 17.6 1.3 0.0069 17.0 0.1 2.0 2 1 0 2 2 2 1 Alpha/beta hydrolase family Chlorophyllase PF07224.11 CCF44330.1 - 0.056 12.4 0.0 1.4 7.9 0.0 2.1 2 0 0 2 2 2 0 Chlorophyllase AA_permease_2 PF13520.6 CCF44331.1 - 7.1e-41 140.4 20.6 8.9e-41 140.1 20.6 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CCF44331.1 - 4e-22 78.5 21.9 5.3e-22 78.1 21.9 1.0 1 0 0 1 1 1 1 Amino acid permease DUF334 PF03904.13 CCF44331.1 - 1.9 8.0 3.2 1.5 8.3 1.3 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF334) adh_short_C2 PF13561.6 CCF44333.1 - 1e-58 198.7 3.5 2.1e-58 197.6 3.5 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF44333.1 - 1.8e-34 118.9 5.7 1.3e-33 116.1 5.7 1.9 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF44333.1 - 3.4e-06 27.1 0.6 6.5e-06 26.2 0.6 1.6 1 1 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 CCF44333.1 - 0.008 16.1 0.3 0.014 15.3 0.3 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AIRC PF00731.20 CCF44333.1 - 0.04 13.5 0.4 0.92 9.1 0.0 2.4 1 1 1 2 2 2 0 AIR carboxylase 2-Hacid_dh_C PF02826.19 CCF44333.1 - 0.044 13.1 0.1 0.1 11.9 0.1 1.7 1 1 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain SBDS_C PF09377.10 CCF44333.1 - 0.11 12.6 0.2 0.15 12.0 0.2 1.5 1 1 0 1 1 1 0 SBDS protein C-terminal domain TauD PF02668.16 CCF44334.1 - 7.2e-39 134.2 0.1 9.8e-39 133.7 0.1 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.12 CCF44334.1 - 1.1e-12 48.5 0.2 2.2e-12 47.4 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF971) CsiD PF08943.10 CCF44334.1 - 0.16 11.1 0.0 0.27 10.3 0.0 1.3 1 0 0 1 1 1 0 CsiD Lustrin_cystein PF14625.6 CCF44335.1 - 8.6 6.8 21.2 15 6.0 8.2 3.4 2 1 0 2 2 2 0 Lustrin, cysteine-rich repeated domain DEP PF00610.21 CCF44336.1 - 3.4e-26 91.1 0.0 1.5e-21 76.2 0.0 3.3 3 0 0 3 3 3 3 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Replic_Relax PF13814.6 CCF44336.1 - 0.0064 16.6 0.0 0.17 12.0 0.0 2.2 2 0 0 2 2 2 1 Replication-relaxation NMT PF01233.19 CCF44336.1 - 0.12 12.2 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain Glyco_hydro_18 PF00704.28 CCF44337.1 - 3.4e-61 207.7 0.4 4.1e-61 207.4 0.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 GHL10 PF02638.15 CCF44337.1 - 0.062 12.4 0.0 0.094 11.8 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase-like 10 adh_short_C2 PF13561.6 CCF44338.1 - 1.6e-58 198.1 0.1 2e-58 197.7 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF44338.1 - 1.6e-52 177.8 0.2 1.6e-52 177.8 0.2 1.6 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 CCF44338.1 - 1.5e-13 51.0 0.7 3.4e-13 49.9 0.7 1.7 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF44338.1 - 6.9e-09 35.5 0.0 9.2e-09 35.1 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 CCF44338.1 - 0.0081 15.3 0.4 0.024 13.8 0.2 1.8 2 0 0 2 2 2 1 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 CCF44338.1 - 0.03 13.7 0.8 0.047 13.1 0.0 1.7 3 0 0 3 3 3 0 GDP-mannose 4,6 dehydratase DUF1815 PF08844.10 CCF44338.1 - 0.047 13.7 0.0 0.09 12.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1815) NmrA PF05368.13 CCF44338.1 - 0.082 12.4 2.7 0.33 10.5 0.9 2.6 2 1 0 3 3 3 0 NmrA-like family DUF3425 PF11905.8 CCF44340.1 - 4.5e-15 55.7 0.3 5.5e-15 55.4 0.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) AIRS_C PF02769.22 CCF44341.1 - 4.6e-27 95.1 0.0 1.5e-26 93.4 0.1 1.7 2 0 0 2 2 2 1 AIR synthase related protein, C-terminal domain FGAR-AT_N PF18076.1 CCF44341.1 - 7.2e-25 87.2 0.0 1.3e-24 86.4 0.0 1.4 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase N-terminal FGAR-AT_linker PF18072.1 CCF44341.1 - 5.3e-23 81.3 0.0 1e-22 80.4 0.0 1.5 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase linker domain DUF3378 PF11858.8 CCF44341.1 - 0.13 12.4 0.1 0.31 11.2 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3378) MLVIN_C PF18697.1 CCF44341.1 - 0.14 12.2 0.3 0.48 10.6 0.3 1.9 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain Nefa_Nip30_N PF10187.9 CCF44342.1 - 9.3e-31 106.3 12.5 9.3e-31 106.3 12.5 1.8 2 0 0 2 2 2 1 N-terminal domain of NEFA-interacting nuclear protein NIP30 DUF4407 PF14362.6 CCF44342.1 - 6.2 6.1 8.1 10 5.4 8.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Aldo_ket_red PF00248.21 CCF44343.1 - 2.1e-62 211.0 0.0 2.6e-62 210.7 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family MFS_1 PF07690.16 CCF44345.1 - 7.3e-39 133.7 46.4 8.5e-39 133.5 44.3 2.2 2 1 0 2 2 2 1 Major Facilitator Superfamily DUF5337 PF17272.2 CCF44345.1 - 0.067 13.0 2.9 0.092 12.6 0.5 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5337) Fungal_trans PF04082.18 CCF44346.1 - 1.5e-10 40.6 0.0 2.3e-10 40.0 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF44346.1 - 7.8e-09 35.5 10.0 1.8e-08 34.4 10.0 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Filament PF00038.21 CCF44347.1 - 3e-05 23.8 17.5 3e-05 23.8 17.5 4.9 2 1 2 4 4 4 1 Intermediate filament protein Jnk-SapK_ap_N PF09744.9 CCF44347.1 - 0.0015 18.7 8.5 0.0015 18.7 8.5 5.1 4 1 2 6 6 6 1 JNK_SAPK-associated protein-1 HOOK PF05622.12 CCF44347.1 - 0.0017 16.6 14.4 0.0017 16.6 14.4 2.8 2 1 1 3 3 3 1 HOOK protein ATG16 PF08614.11 CCF44347.1 - 0.013 15.8 14.8 0.013 15.8 14.8 5.7 3 1 3 6 6 5 0 Autophagy protein 16 (ATG16) Lzipper-MIP1 PF14389.6 CCF44347.1 - 0.026 14.8 3.0 0.026 14.8 3.0 5.1 3 1 1 5 5 5 0 Leucine-zipper of ternary complex factor MIP1 ZapB PF06005.12 CCF44347.1 - 0.029 14.8 1.4 0.029 14.8 1.4 7.2 5 1 1 6 6 5 0 Cell division protein ZapB DivIC PF04977.15 CCF44347.1 - 0.069 12.9 52.9 0.088 12.6 3.3 7.2 6 2 1 7 7 7 0 Septum formation initiator TSC22 PF01166.18 CCF44347.1 - 0.11 12.8 0.3 0.11 12.8 0.3 5.5 6 0 0 6 6 5 0 TSC-22/dip/bun family CCDC92 PF14916.6 CCF44347.1 - 0.17 11.7 0.0 0.17 11.7 0.0 3.9 4 1 0 4 4 4 0 Coiled-coil domain of unknown function TcdB_N PF12918.7 CCF44347.1 - 0.25 11.6 5.3 1.6 9.1 0.0 3.7 3 1 0 3 3 3 0 TcdB toxin N-terminal helical domain HALZ PF02183.18 CCF44347.1 - 0.45 10.8 31.1 0.13 12.5 1.0 6.4 6 1 1 7 7 7 0 Homeobox associated leucine zipper EzrA PF06160.12 CCF44347.1 - 1.3 7.1 34.4 5.2 5.1 18.1 2.7 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA DUF4407 PF14362.6 CCF44347.1 - 2.4 7.5 59.8 0.0094 15.3 19.3 4.5 1 1 4 5 5 5 0 Domain of unknown function (DUF4407) Spc7 PF08317.11 CCF44347.1 - 4 6.2 54.7 0.041 12.7 6.3 3.4 4 1 0 4 4 4 0 Spc7 kinetochore protein Band_7 PF01145.25 CCF44347.1 - 4.4 7.3 11.9 1.8 8.6 8.3 2.1 1 1 0 1 1 1 0 SPFH domain / Band 7 family ADIP PF11559.8 CCF44347.1 - 5.7 7.0 62.2 0.027 14.6 14.4 5.2 4 1 2 6 6 6 0 Afadin- and alpha -actinin-Binding MAD PF05557.13 CCF44347.1 - 7.1 4.9 52.5 0.47 8.7 6.6 3.8 3 1 1 4 4 4 0 Mitotic checkpoint protein FlaG PF03646.15 CCF44352.1 - 0.055 13.6 0.0 0.076 13.2 0.0 1.2 1 0 0 1 1 1 0 FlaG protein CHCH PF06747.13 CCF44354.1 - 1.5e-06 28.1 3.0 2.5e-06 27.5 3.0 1.4 1 0 0 1 1 1 1 CHCH domain MTCP1 PF08991.10 CCF44354.1 - 0.004 17.4 2.2 0.0063 16.7 2.2 1.3 1 0 0 1 1 1 1 Mature-T-Cell Proliferation I type Pet191_N PF10203.9 CCF44354.1 - 0.0045 17.3 4.6 0.0088 16.3 4.1 1.7 1 1 0 1 1 1 1 Cytochrome c oxidase assembly protein PET191 AAA_9 PF12781.7 CCF44356.1 - 1.2e-41 142.3 1.1 6.3e-40 136.6 0.5 3.0 3 0 0 3 3 3 1 ATP-binding dynein motor region AAA_lid_11 PF18198.1 CCF44356.1 - 3.4e-30 105.0 0.1 9.6e-30 103.5 0.0 1.8 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 CCF44356.1 - 3.3e-29 101.4 0.3 2.3e-28 98.7 0.0 2.5 3 0 0 3 3 3 1 Dynein heavy chain region D6 P-loop domain UCH PF00443.29 CCF44356.1 - 0.083 12.4 0.0 0.17 11.3 0.0 1.5 1 1 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase MbeB_N PF04837.12 CCF44356.1 - 0.11 12.8 0.1 0.39 11.1 0.1 2.0 1 0 0 1 1 1 0 MbeB-like, N-term conserved region KELK PF15796.5 CCF44356.1 - 0.12 12.8 0.7 0.32 11.5 0.7 1.7 1 0 0 1 1 1 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase Fibin PF15819.5 CCF44356.1 - 0.13 12.0 0.7 0.25 11.1 0.7 1.4 1 0 0 1 1 1 0 Fin bud initiation factor homologue Hemerythrin PF01814.23 CCF44356.1 - 0.14 12.8 0.3 0.4 11.3 0.1 1.9 2 0 0 2 2 2 0 Hemerythrin HHE cation binding domain Sulfatase PF00884.23 CCF44357.1 - 1e-60 205.7 0.2 1.7e-60 205.0 0.2 1.3 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 CCF44357.1 - 2.8e-06 27.2 0.3 1.6e-05 24.7 0.3 1.9 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.17 CCF44357.1 - 0.0053 15.4 0.0 0.0085 14.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF229) DUF1501 PF07394.12 CCF44357.1 - 0.11 11.6 0.0 0.17 10.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) Corona_3 PF04694.12 CCF44357.1 - 0.21 12.0 0.2 0.4 11.1 0.2 1.4 1 0 0 1 1 1 0 Coronavirus ORF3 protein LSM PF01423.22 CCF44358.1 - 2.4e-16 59.2 0.0 3.2e-16 58.8 0.0 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 CCF44358.1 - 0.023 14.8 0.0 0.033 14.3 0.0 1.2 1 0 0 1 1 1 0 Ataxin 2 SM domain RAM PF15320.6 CCF44358.1 - 4.2 8.0 12.5 6.5 7.4 12.5 1.2 1 0 0 1 1 1 0 mRNA cap methylation, RNMT-activating mini protein PPR_2 PF13041.6 CCF44359.1 - 2.6e-07 30.7 0.2 7.8 6.8 0.1 5.2 4 1 1 5 5 5 3 PPR repeat family PPR PF01535.20 CCF44359.1 - 0.00018 21.6 7.1 2.9 8.4 0.1 4.6 6 0 0 6 6 6 3 PPR repeat PPR_3 PF13812.6 CCF44359.1 - 0.00023 21.2 0.4 0.14 12.3 0.0 3.6 3 0 0 3 3 3 1 Pentatricopeptide repeat domain PPR_1 PF12854.7 CCF44359.1 - 0.068 12.9 3.2 7.1 6.4 0.1 3.1 3 0 0 3 3 3 0 PPR repeat TPR_12 PF13424.6 CCF44359.1 - 2.7 8.3 5.8 44 4.5 0.3 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat MFS_1 PF07690.16 CCF44360.1 - 2e-31 109.2 42.5 2e-31 109.2 42.5 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily EphA2_TM PF14575.6 CCF44362.1 - 4.1e-05 24.4 0.0 5.2e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain Syndecan PF01034.20 CCF44362.1 - 0.0019 18.1 0.7 0.003 17.4 0.7 1.3 1 0 0 1 1 1 1 Syndecan domain GRP PF07172.11 CCF44362.1 - 0.0051 17.5 5.6 0.0061 17.2 4.9 1.4 1 1 0 1 1 1 1 Glycine rich protein family Adeno_E3_CR2 PF02439.15 CCF44362.1 - 0.021 14.6 5.7 0.034 13.9 5.7 1.2 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Amnionless PF14828.6 CCF44362.1 - 0.021 13.6 0.0 0.023 13.5 0.0 1.0 1 0 0 1 1 1 0 Amnionless SARAF PF06682.12 CCF44362.1 - 0.025 14.2 0.1 0.028 14.1 0.1 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Fumarate_red_D PF02313.17 CCF44362.1 - 0.034 14.2 0.0 0.053 13.6 0.0 1.2 1 0 0 1 1 1 0 Fumarate reductase subunit D DAG1 PF05454.11 CCF44362.1 - 0.037 13.4 0.1 0.042 13.2 0.1 1.1 1 0 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) DUF4690 PF15756.5 CCF44362.1 - 0.046 14.3 0.8 0.076 13.6 0.8 1.4 1 0 0 1 1 1 0 Small Novel Rich in Cartilage DUF4834 PF16118.5 CCF44362.1 - 0.057 14.4 0.0 0.076 14.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Shisa PF13908.6 CCF44362.1 - 0.057 13.7 0.0 0.062 13.6 0.0 1.2 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator ECSCR PF15820.5 CCF44362.1 - 0.07 13.0 0.0 0.087 12.7 0.0 1.1 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator DUF3951 PF13131.6 CCF44362.1 - 0.074 13.3 0.4 0.13 12.5 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3951) DUF3169 PF11368.8 CCF44362.1 - 0.074 12.6 0.0 0.093 12.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3169) RIFIN PF02009.16 CCF44362.1 - 0.078 12.9 0.3 0.096 12.6 0.3 1.1 1 0 0 1 1 1 0 Rifin ASFV_J13L PF05568.11 CCF44362.1 - 0.11 12.2 0.5 0.18 11.6 0.3 1.5 1 1 0 1 1 1 0 African swine fever virus J13L protein Vpu PF00558.19 CCF44362.1 - 0.11 12.2 0.1 0.33 10.8 0.1 1.6 2 0 0 2 2 2 0 Vpu protein LapA_dom PF06305.11 CCF44362.1 - 0.13 12.1 0.1 0.21 11.4 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Insulin_TMD PF17870.1 CCF44362.1 - 0.15 12.1 2.9 0.25 11.4 2.9 1.3 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment DUF4381 PF14316.6 CCF44362.1 - 0.16 12.2 0.0 0.29 11.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) DUF5305 PF17231.2 CCF44362.1 - 0.18 11.2 0.1 0.21 11.0 0.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5305) Protocadherin PF08374.11 CCF44362.1 - 0.25 11.3 0.4 0.31 11.0 0.4 1.1 1 0 0 1 1 1 0 Protocadherin FeoB_associated PF12669.7 CCF44362.1 - 6.7 7.2 7.5 17 5.9 7.5 1.6 1 1 0 1 1 1 0 FeoB-associated Cys-rich membrane protein MAP17 PF15807.5 CCF44364.1 - 0.12 12.7 0.0 0.14 12.4 0.0 1.1 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 DUF2615 PF11027.8 CCF44364.1 - 0.12 12.5 0.0 0.16 12.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2615) DUF3287 PF11690.8 CCF44366.1 - 0.017 14.9 1.6 0.04 13.6 1.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3287) DUF1510 PF07423.11 CCF44366.1 - 0.066 13.4 0.8 0.3 11.2 0.8 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1510) Enkurin PF13864.6 CCF44366.1 - 0.24 11.9 20.3 0.034 14.6 5.7 3.4 2 1 0 2 2 2 0 Calmodulin-binding Spc7 PF08317.11 CCF44366.1 - 1.3 7.8 28.8 4.3 6.1 5.5 2.4 1 1 1 2 2 2 0 Spc7 kinetochore protein Macoilin PF09726.9 CCF44366.1 - 1.5 7.3 26.9 1 7.8 25.3 1.5 1 1 0 1 1 1 0 Macoilin family COG5 PF10392.9 CCF44366.1 - 2.5 8.3 7.3 0.63 10.2 1.1 2.4 2 0 0 2 2 2 0 Golgi transport complex subunit 5 Sugar_tr PF00083.24 CCF44367.1 - 9.5e-30 103.8 19.4 1.1e-29 103.7 19.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF44367.1 - 2.2e-15 56.5 10.5 2.7e-15 56.2 10.5 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily RseC_MucC PF04246.12 CCF44367.1 - 0.37 10.7 3.9 0.13 12.2 0.5 2.0 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC DUF1673 PF07895.11 CCF44367.1 - 3.1 7.4 10.9 10 5.7 10.6 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1673) ABC_membrane PF00664.23 CCF44369.1 - 2.6e-33 115.8 12.3 3.3e-33 115.5 12.3 1.0 1 0 0 1 1 1 1 ABC transporter transmembrane region AP_endonuc_2 PF01261.24 CCF44370.1 - 2.6e-27 95.7 0.1 3.8e-27 95.1 0.1 1.2 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel DUF2124 PF09897.9 CCF44370.1 - 0.028 14.3 0.0 0.057 13.3 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2124) DUF5571 PF17732.1 CCF44370.1 - 0.028 13.9 3.3 0.047 13.1 3.3 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5571) NARP1 PF12569.8 CCF44370.1 - 9.3 5.0 11.4 3.1 6.6 8.8 1.5 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 DAGAT PF03982.13 CCF44371.1 - 9.3e-51 172.5 0.0 1e-50 172.4 0.0 1.0 1 0 0 1 1 1 1 Diacylglycerol acyltransferase Sugar_tr PF00083.24 CCF44372.1 - 1.2e-72 245.2 27.4 1.4e-72 245.1 27.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF44372.1 - 1.2e-18 67.2 31.1 1.2e-18 67.2 31.1 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_2 PF13347.6 CCF44372.1 - 0.0012 17.5 3.9 0.0012 17.5 3.9 3.1 2 1 1 3 3 3 2 MFS/sugar transport protein adh_short PF00106.25 CCF44375.1 - 2.1e-28 99.1 0.0 6e-16 58.5 0.0 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCF44375.1 - 1.3e-11 44.6 0.0 1.4e-05 24.8 0.0 2.3 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF44375.1 - 2.9e-06 27.3 0.3 0.0012 18.8 0.1 2.4 1 1 2 3 3 3 2 KR domain NAD_binding_10 PF13460.6 CCF44375.1 - 0.00025 21.0 0.1 0.00039 20.3 0.1 1.2 1 0 0 1 1 1 1 NAD(P)H-binding DUF1776 PF08643.10 CCF44375.1 - 0.00091 18.7 0.2 0.0013 18.2 0.2 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Epimerase PF01370.21 CCF44375.1 - 0.015 14.7 0.0 0.035 13.6 0.0 1.6 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 CCF44375.1 - 0.021 15.1 0.0 0.057 13.7 0.0 1.8 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain NmrA PF05368.13 CCF44377.1 - 3.5e-16 59.5 0.0 4.2e-16 59.2 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CCF44377.1 - 7.3e-13 48.8 0.0 1.4e-12 47.9 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Shikimate_DH PF01488.20 CCF44377.1 - 0.018 15.1 0.0 0.032 14.3 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Semialdhyde_dh PF01118.24 CCF44377.1 - 0.025 15.0 0.1 0.052 14.0 0.1 1.5 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.20 CCF44377.1 - 0.066 13.3 0.0 0.13 12.4 0.0 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Hydrolase PF00702.26 CCF44378.1 - 3e-10 40.8 0.0 1.4e-09 38.6 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 CCF44378.1 - 1.6e-09 38.1 0.0 2.7e-09 37.4 0.0 1.5 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CCF44378.1 - 5e-06 26.5 0.0 8.9e-06 25.7 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like DUF3226 PF11536.8 CCF44378.1 - 0.0058 16.3 0.0 0.0084 15.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3226) DAGK_cat PF00781.24 CCF44379.1 - 5.9e-08 32.4 0.0 2.8e-07 30.2 0.0 2.1 1 1 0 1 1 1 1 Diacylglycerol kinase catalytic domain adh_short_C2 PF13561.6 CCF44380.1 - 4.6e-11 42.7 0.2 4.7e-11 42.7 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Ras PF00071.22 CCF44381.1 - 2.5e-39 134.5 0.0 8.1e-26 90.5 0.0 2.1 2 0 0 2 2 2 2 Ras family Roc PF08477.13 CCF44381.1 - 3.9e-12 46.4 0.0 9.7e-12 45.2 0.0 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCF44381.1 - 0.00041 19.8 0.0 0.0018 17.8 0.0 1.8 2 0 0 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 CCF44381.1 - 0.0017 18.4 0.0 0.0027 17.8 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CCF44381.1 - 0.059 12.9 0.0 0.74 9.3 0.0 2.4 2 1 1 3 3 3 0 Elongation factor Tu GTP binding domain PRK PF00485.18 CCF44381.1 - 0.11 12.2 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family Ribosomal_L29 PF00831.23 CCF44382.1 - 0.045 13.7 2.0 0.069 13.1 2.0 1.4 1 0 0 1 1 1 0 Ribosomal L29 protein PDR_CDR PF06422.12 CCF44383.1 - 7e-31 106.0 0.0 1.9e-30 104.6 0.0 1.8 1 0 0 1 1 1 1 CDR ABC transporter ABC2_membrane PF01061.24 CCF44383.1 - 2.3e-30 105.6 18.0 4e-30 104.8 18.0 1.4 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 CCF44383.1 - 2.4e-16 60.5 0.0 6.3e-16 59.1 0.0 1.7 2 0 0 2 2 2 1 ABC transporter AAA_16 PF13191.6 CCF44383.1 - 4.5e-06 27.1 0.1 9.4e-06 26.1 0.1 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.6 CCF44383.1 - 3.4e-05 23.5 0.2 0.00014 21.5 0.2 1.9 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 CCF44383.1 - 5.6e-05 23.1 0.0 0.00013 22.0 0.0 1.6 1 0 0 1 1 1 1 RsgA GTPase SMC_N PF02463.19 CCF44383.1 - 0.00036 20.0 0.0 0.13 11.7 0.0 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 CCF44383.1 - 0.00043 20.2 0.0 0.17 11.6 0.0 2.3 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CCF44383.1 - 0.00055 19.6 1.1 0.001 18.7 0.2 1.9 2 0 0 2 2 1 1 P-loop containing region of AAA domain AAA_18 PF13238.6 CCF44383.1 - 0.00061 20.3 0.0 0.0011 19.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 CCF44383.1 - 0.0013 18.9 0.0 0.0026 17.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain ABC2_membrane_3 PF12698.7 CCF44383.1 - 0.0017 17.5 10.7 0.0026 17.0 10.7 1.3 1 0 0 1 1 1 1 ABC-2 family transporter protein AAA_23 PF13476.6 CCF44383.1 - 0.023 15.2 0.0 0.038 14.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 CCF44383.1 - 0.032 14.5 0.0 0.062 13.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 CCF44383.1 - 0.045 13.7 0.1 0.087 12.7 0.1 1.4 1 0 0 1 1 1 0 NACHT domain cobW PF02492.19 CCF44383.1 - 0.051 13.2 0.1 0.092 12.3 0.1 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_28 PF13521.6 CCF44383.1 - 0.055 13.7 0.1 0.12 12.6 0.1 1.6 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.6 CCF44383.1 - 0.081 13.4 0.0 0.15 12.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain SRP54 PF00448.22 CCF44383.1 - 0.13 11.9 0.1 0.22 11.1 0.1 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain TRP_N PF14558.6 CCF44385.1 - 2.7e-25 89.4 0.0 4e-25 88.8 0.0 1.3 1 0 0 1 1 1 1 ML-like domain TRP PF06011.12 CCF44385.1 - 1.4e-10 40.5 4.7 8.6e-09 34.6 4.7 2.2 1 1 0 1 1 1 1 Transient receptor potential (TRP) ion channel PAN_1 PF00024.26 CCF44386.1 - 5.1e-05 23.1 13.4 0.0091 15.9 0.0 4.7 4 1 0 4 4 4 2 PAN domain PAN_4 PF14295.6 CCF44386.1 - 0.001 18.9 29.5 0.0041 17.0 2.1 4.7 4 0 0 4 4 4 3 PAN domain Whib PF02467.16 CCF44386.1 - 0.19 12.4 7.2 0.92 10.1 0.2 4.0 4 0 0 4 4 4 0 Transcription factor WhiB HTH_psq PF05225.16 CCF44387.1 - 9.3e-09 34.9 0.0 1.3e-08 34.4 0.0 1.3 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.16 CCF44387.1 - 3.5e-06 27.0 0.0 2.7e-05 24.1 0.0 2.0 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_23 PF13384.6 CCF44387.1 - 0.00033 20.4 0.1 0.00063 19.5 0.1 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_30 PF13556.6 CCF44387.1 - 0.002 17.9 0.0 0.0043 16.8 0.0 1.6 2 0 0 2 2 2 1 PucR C-terminal helix-turn-helix domain HTH_1 PF00126.27 CCF44387.1 - 0.084 12.8 0.1 0.16 11.9 0.1 1.4 1 0 0 1 1 1 0 Bacterial regulatory helix-turn-helix protein, lysR family Fungal_trans PF04082.18 CCF44388.1 - 5.7e-12 45.2 0.8 1.3e-11 44.1 0.8 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF44388.1 - 0.00052 20.1 7.4 0.001 19.1 7.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pyr_redox_2 PF07992.14 CCF44389.1 - 1.8e-36 125.9 0.4 2.3e-36 125.6 0.4 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCF44389.1 - 9.2e-16 58.2 0.6 2.5e-11 44.0 0.1 3.1 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCF44389.1 - 1.1e-06 28.2 0.2 6.6e-05 22.3 0.0 2.6 2 1 1 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CCF44389.1 - 4.4e-05 23.5 1.4 0.17 11.8 0.0 3.8 3 1 1 4 4 4 2 FAD-NAD(P)-binding Lycopene_cycl PF05834.12 CCF44389.1 - 0.0017 17.5 1.0 0.004 16.3 0.0 2.1 3 0 0 3 3 3 1 Lycopene cyclase protein DAO PF01266.24 CCF44389.1 - 0.0019 17.8 6.7 0.085 12.4 0.0 4.2 5 0 0 5 5 5 1 FAD dependent oxidoreductase K_oxygenase PF13434.6 CCF44389.1 - 0.0061 15.8 0.6 0.29 10.2 0.4 2.4 2 1 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.17 CCF44389.1 - 0.033 13.4 0.7 1.6 7.9 0.0 2.4 2 0 0 2 2 2 0 Thi4 family TrkA_N PF02254.18 CCF44389.1 - 0.039 14.2 1.2 21 5.4 0.0 3.3 3 1 0 3 3 3 0 TrkA-N domain Trp_halogenase PF04820.14 CCF44389.1 - 0.057 12.3 2.8 9.8 4.9 1.0 3.0 2 1 0 3 3 3 0 Tryptophan halogenase Malic_M PF03949.15 CCF44389.1 - 0.094 12.0 1.8 0.2 10.9 0.0 2.3 2 1 0 2 2 2 0 Malic enzyme, NAD binding domain Beta_helix PF13229.6 CCF44390.1 - 4.2e-13 49.5 9.7 4.1e-11 43.0 3.5 2.1 1 1 1 2 2 2 2 Right handed beta helix region NosD PF05048.13 CCF44390.1 - 2.6e-05 23.6 4.9 0.0061 15.8 0.1 2.3 2 0 0 2 2 2 2 Periplasmic copper-binding protein (NosD) DUF3395 PF11875.8 CCF44391.1 - 7e-29 100.7 0.0 9e-29 100.4 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3395) Fungal_trans_2 PF11951.8 CCF44392.1 - 3.2e-07 29.5 0.0 4.5e-07 29.0 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain C5-epim_C PF06662.13 CCF44392.1 - 0.032 13.7 0.1 0.12 11.9 0.0 1.8 2 0 0 2 2 2 0 D-glucuronyl C5-epimerase C-terminus TAL_FSA PF00923.19 CCF44393.1 - 7.7e-94 314.2 0.8 8.7e-94 314.1 0.8 1.0 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase Robl_LC7 PF03259.17 CCF44394.1 - 2.8e-08 33.4 0.0 3.4e-05 23.5 0.0 2.1 2 0 0 2 2 2 2 Roadblock/LC7 domain LAMTOR5 PF16672.5 CCF44394.1 - 0.072 13.0 0.0 0.24 11.3 0.0 1.8 2 0 0 2 2 2 0 Ragulator complex protein LAMTOR5 Acetyltransf_1 PF00583.25 CCF44395.1 - 1.9e-08 34.5 0.0 3.6e-08 33.7 0.0 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CCF44395.1 - 1.4e-07 31.5 0.0 2.1e-07 30.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CCF44395.1 - 7.5e-07 29.5 0.0 1.1e-06 29.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CCF44395.1 - 0.017 15.1 0.0 0.038 14.0 0.0 1.5 2 0 0 2 2 2 0 FR47-like protein ATP-grasp_2 PF08442.10 CCF44396.1 - 2.2e-17 63.3 0.0 2.8e-17 62.9 0.0 1.1 1 0 0 1 1 1 1 ATP-grasp domain adh_short_C2 PF13561.6 CCF44397.1 - 8.9e-22 77.8 0.0 9.6e-22 77.7 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF44397.1 - 0.019 14.4 0.0 0.023 14.1 0.0 1.1 1 0 0 1 1 1 0 short chain dehydrogenase Kin17_mid PF10357.9 CCF44401.1 - 8.3e-51 171.2 1.5 8.3e-51 171.2 1.5 2.3 3 0 0 3 3 3 1 Domain of Kin17 curved DNA-binding protein zf-met PF12874.7 CCF44401.1 - 2.5e-05 24.5 3.4 5e-05 23.6 3.4 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 CCF44401.1 - 2.6e-05 24.4 2.2 6e-05 23.2 2.2 1.7 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 CCF44401.1 - 0.0051 17.1 0.4 0.0051 17.1 0.4 2.3 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) NOD PF06816.13 CCF44401.1 - 0.025 14.2 0.0 0.056 13.1 0.0 1.5 1 0 0 1 1 1 0 NOTCH protein Spt4 PF06093.13 CCF44402.1 - 8.2e-33 112.4 0.3 1e-32 112.1 0.3 1.1 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger Coronavirus_5 PF05528.11 CCF44402.1 - 0.03 14.3 0.4 0.095 12.7 0.2 1.9 1 1 1 2 2 2 0 Coronavirus gene 5 protein Cys_rich_CPXG PF14255.6 CCF44402.1 - 0.7 9.8 4.0 9.3 6.2 0.0 2.7 2 1 0 2 2 2 0 Cysteine-rich CPXCG PPP5 PF08321.12 CCF44404.1 - 8.1e-33 112.6 2.6 1.1e-32 112.2 1.0 1.9 2 0 0 2 2 2 1 PPP5 TPR repeat region Metallophos PF00149.28 CCF44404.1 - 2.5e-31 109.8 0.1 3.9e-31 109.2 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase TPR_1 PF00515.28 CCF44404.1 - 7.7e-18 63.5 1.8 0.00028 20.6 0.1 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 CCF44404.1 - 7.5e-12 44.4 0.5 0.023 14.8 0.1 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 CCF44404.1 - 9.5e-11 41.2 2.8 0.00014 21.5 0.1 3.4 3 0 0 3 3 3 2 TPR repeat TPR_17 PF13431.6 CCF44404.1 - 2.4e-06 27.5 3.2 0.66 10.5 0.0 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 CCF44404.1 - 4.7e-06 26.4 0.7 1.2 9.5 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 CCF44404.1 - 0.00026 21.1 0.0 0.08 13.1 0.0 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 CCF44404.1 - 0.0053 17.5 0.1 6.6 7.8 0.0 3.2 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 CCF44404.1 - 0.012 16.2 0.1 34 5.1 0.0 3.3 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 CCF44404.1 - 0.043 14.5 0.1 0.77 10.5 0.0 2.4 1 1 1 2 2 2 0 Tetratricopeptide repeat PIN_5 PF08745.11 CCF44404.1 - 0.053 12.9 0.1 0.084 12.3 0.1 1.2 1 0 0 1 1 1 0 PINc domain ribonuclease Es2 PF09751.9 CCF44405.1 - 3e-121 406.2 6.7 3.5e-121 405.9 6.7 1.1 1 0 0 1 1 1 1 Nuclear protein Es2 ABC1 PF03109.16 CCF44406.1 - 5.1e-32 110.5 0.0 1.1e-31 109.5 0.0 1.6 1 0 0 1 1 1 1 ABC1 family Mucin PF01456.17 CCF44406.1 - 0.25 11.4 4.9 0.53 10.3 4.9 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein RRP36 PF06102.12 CCF44407.1 - 9.4e-27 94.0 27.8 1.1e-26 93.8 27.8 1.0 1 0 0 1 1 1 1 rRNA biogenesis protein RRP36 Sec10 PF07393.11 CCF44408.1 - 4.9e-125 418.6 3.5 4.9e-125 418.6 3.5 1.4 2 0 0 2 2 2 1 Exocyst complex component Sec10 AsnA PF03590.15 CCF44408.1 - 0.018 14.8 0.3 0.66 9.7 0.0 2.2 2 0 0 2 2 2 0 Aspartate-ammonia ligase DUF4810 PF16068.5 CCF44408.1 - 0.1 13.1 0.4 0.73 10.4 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4810) DUF4407 PF14362.6 CCF44408.1 - 1 8.6 6.3 0.45 9.8 3.4 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) BTB PF00651.31 CCF44409.1 - 0.13 12.5 0.0 0.21 11.8 0.0 1.3 1 0 0 1 1 1 0 BTB/POZ domain Peptidase_M24 PF00557.24 CCF44410.1 - 0.078 12.7 0.0 0.086 12.5 0.0 1.1 1 0 0 1 1 1 0 Metallopeptidase family M24 Flavin_Reduct PF01613.18 CCF44411.1 - 4.3e-12 46.3 0.0 5.8e-12 45.9 0.0 1.1 1 0 0 1 1 1 1 Flavin reductase like domain Putative_PNPOx PF01243.20 CCF44411.1 - 0.0083 16.3 0.0 0.014 15.6 0.0 1.4 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase p450 PF00067.22 CCF44413.1 - 0.00043 19.2 0.0 0.00047 19.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 SIR2 PF02146.17 CCF44415.1 - 1.2e-30 106.8 0.0 1.6e-30 106.3 0.0 1.2 1 0 0 1 1 1 1 Sir2 family TcA_TcB_BD PF18276.1 CCF44418.1 - 0.0041 16.3 0.3 0.012 14.7 0.3 1.8 1 1 1 2 2 2 1 Tc toxin complex TcA C-terminal TcB-binding domain GMC_oxred_C PF05199.13 CCF44419.1 - 1.4e-27 97.0 0.0 3.1e-27 95.9 0.0 1.6 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_N PF00732.19 CCF44419.1 - 5.6e-27 94.9 0.0 6.1e-25 88.2 0.0 2.5 2 1 0 2 2 2 1 GMC oxidoreductase Pyr_redox_2 PF07992.14 CCF44419.1 - 0.00031 20.1 0.0 0.00067 19.0 0.0 1.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCF44419.1 - 0.0053 17.0 0.1 0.012 15.8 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 CCF44419.1 - 0.0079 15.3 0.0 0.013 14.6 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.12 CCF44419.1 - 0.019 14.0 0.0 0.031 13.3 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein FAD_binding_3 PF01494.19 CCF44419.1 - 0.05 12.8 0.1 0.078 12.2 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain ThiF PF00899.21 CCF44419.1 - 0.066 12.6 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 ThiF family Pyr_redox_3 PF13738.6 CCF44419.1 - 0.14 11.4 0.1 15 4.7 0.1 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Methyltransf_2 PF00891.18 CCF44421.1 - 2.1e-08 33.8 0.1 3e-08 33.2 0.1 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_18 PF12847.7 CCF44421.1 - 0.016 15.1 0.0 0.029 14.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain MT0933_antitox PF14013.6 CCF44423.1 - 0.00053 20.2 5.6 0.00076 19.7 4.6 1.8 2 0 0 2 2 2 1 MT0933-like antitoxin protein p450 PF00067.22 CCF44424.1 - 1e-57 196.0 0.0 1.1e-57 195.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Conotoxin PF02950.17 CCF44426.1 - 0.013 16.5 2.1 0.019 16.0 2.1 1.3 1 0 0 1 1 1 0 Conotoxin Toxin_12 PF07740.12 CCF44426.1 - 0.05 14.3 1.4 0.05 14.3 1.4 1.5 2 0 0 2 2 2 0 Ion channel inhibitory toxin ADH_zinc_N PF00107.26 CCF44427.1 - 9.2e-10 38.6 0.3 1.9e-09 37.6 0.0 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCF44427.1 - 9.2e-06 25.5 0.0 1.7e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 CCF44427.1 - 0.0014 19.7 0.0 0.0037 18.3 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Brix PF04427.18 CCF44428.1 - 9.1e-22 78.1 0.0 1.2e-21 77.7 0.0 1.1 1 0 0 1 1 1 1 Brix domain Peptidase_S41 PF03572.18 CCF44429.1 - 4e-05 23.2 0.0 7.5e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 Peptidase family S41 Polysacc_deac_1 PF01522.21 CCF44431.1 - 3.7e-27 94.7 0.0 6.9e-27 93.8 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase Nucleo_P87 PF07267.11 CCF44431.1 - 0.075 11.9 0.4 0.095 11.5 0.4 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 DUF908 PF06012.12 CCF44431.1 - 0.33 10.3 2.5 0.39 10.1 2.5 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) KCT2 PF17818.1 CCF44431.1 - 1.5 8.9 8.4 12 5.9 8.4 2.2 2 0 0 2 2 2 0 Keratinocyte-associated gene product Spore_coat_CotO PF14153.6 CCF44431.1 - 4 7.3 5.4 7.8 6.4 5.4 1.4 1 0 0 1 1 1 0 Spore coat protein CotO HSP70 PF00012.20 CCF44432.1 - 8.3e-30 103.5 0.0 6.2e-20 70.9 0.0 2.0 2 0 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 CCF44432.1 - 2.7e-05 23.2 0.0 3.3e-05 22.9 0.0 1.1 1 0 0 1 1 1 1 MreB/Mbl protein Ad_Cy_reg PF16701.5 CCF44432.1 - 0.087 12.6 0.6 0.19 11.5 0.1 1.8 2 0 0 2 2 2 0 Adenylate cyclase regulatory domain Aldo_ket_red PF00248.21 CCF44433.1 - 4.1e-73 246.2 0.1 4.6e-73 246.0 0.1 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family GMC_oxred_N PF00732.19 CCF44436.1 - 1e-26 94.1 0.0 4.2e-17 62.5 0.0 3.3 3 0 0 3 3 3 3 GMC oxidoreductase GMC_oxred_C PF05199.13 CCF44436.1 - 1.9e-25 90.0 0.0 3.3e-25 89.3 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase NAD_binding_8 PF13450.6 CCF44436.1 - 0.00034 20.8 0.1 0.0011 19.2 0.1 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CCF44436.1 - 0.0007 18.9 0.0 0.0016 17.7 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCF44436.1 - 0.039 13.2 0.0 8.6 5.5 0.0 2.6 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CCF44436.1 - 0.083 11.6 0.2 0.13 11.0 0.2 1.2 1 0 0 1 1 1 0 HI0933-like protein FAD_binding_3 PF01494.19 CCF44436.1 - 0.1 11.8 0.3 0.16 11.2 0.3 1.2 1 0 0 1 1 1 0 FAD binding domain Lycopene_cycl PF05834.12 CCF44436.1 - 0.13 11.3 0.0 0.17 10.9 0.0 1.1 1 0 0 1 1 1 0 Lycopene cyclase protein FAD_binding_2 PF00890.24 CCF44436.1 - 0.16 11.0 0.5 0.25 10.4 0.5 1.3 1 0 0 1 1 1 0 FAD binding domain NmrA PF05368.13 CCF44437.1 - 7.8e-26 91.1 0.0 9.5e-26 90.8 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CCF44437.1 - 2.2e-12 47.2 0.0 4.5e-12 46.2 0.0 1.7 1 1 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 CCF44437.1 - 0.005 17.1 0.1 0.013 15.7 0.0 1.7 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain Semialdhyde_dh PF01118.24 CCF44437.1 - 0.0051 17.2 0.0 0.011 16.2 0.0 1.6 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.20 CCF44437.1 - 0.019 15.1 0.0 0.037 14.2 0.0 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus NAD_binding_4 PF07993.12 CCF44437.1 - 0.11 11.6 0.0 0.19 10.9 0.0 1.3 1 0 0 1 1 1 0 Male sterility protein DUF5376 PF17346.2 CCF44437.1 - 0.12 12.7 0.2 0.21 11.9 0.2 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5376) Dynamin_M PF01031.20 CCF44438.1 - 1.3e-20 73.8 0.0 2.8e-20 72.7 0.0 1.5 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.23 CCF44438.1 - 1.5e-17 64.1 0.0 5.5e-17 62.3 0.0 2.0 2 0 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 CCF44438.1 - 4.5e-05 23.5 0.0 0.0007 19.7 0.0 2.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase Nup188 PF10487.9 CCF44438.1 - 0.0015 16.5 0.7 0.003 15.5 0.5 1.5 2 0 0 2 2 2 1 Nucleoporin subcomplex protein binding to Pom34 AAA_28 PF13521.6 CCF44438.1 - 0.02 15.1 0.2 1 9.6 0.0 3.2 2 0 0 2 2 2 0 AAA domain Radial_spoke PF04712.12 CCF44438.1 - 0.066 12.2 0.1 0.11 11.5 0.1 1.2 1 0 0 1 1 1 0 Radial spokehead-like protein Roc PF08477.13 CCF44438.1 - 0.12 12.6 0.2 8.7 6.6 0.1 3.0 2 1 1 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase SecA_SW PF07516.13 CCF44438.1 - 1.8 8.6 4.7 0.77 9.8 1.0 2.2 2 1 0 2 2 2 0 SecA Wing and Scaffold domain Transferase PF02458.15 CCF44439.1 - 1.9e-05 23.5 0.0 0.0004 19.1 0.0 2.4 2 1 0 2 2 2 2 Transferase family p450 PF00067.22 CCF44440.1 - 1.5e-21 76.7 0.0 3.3e-21 75.6 0.0 1.5 2 0 0 2 2 2 1 Cytochrome P450 HTH_7 PF02796.15 CCF44440.1 - 0.0024 17.9 0.0 0.0061 16.6 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase KR PF08659.10 CCF44441.1 - 2e-53 181.0 0.0 8.3e-53 179.0 0.0 2.0 2 0 0 2 2 2 1 KR domain ADH_zinc_N_2 PF13602.6 CCF44441.1 - 1.4e-15 58.5 0.0 3e-15 57.5 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 CCF44441.1 - 2.2e-14 53.6 0.1 4.6e-14 52.5 0.1 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase adh_short PF00106.25 CCF44441.1 - 3.3e-10 39.7 0.0 5.8e-08 32.4 0.0 2.5 2 1 0 2 2 2 2 short chain dehydrogenase PP-binding PF00550.25 CCF44441.1 - 0.00019 21.7 0.0 0.00046 20.5 0.0 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site YjeF_N PF03853.15 CCF44442.1 - 1.1e-40 139.3 0.1 1.7e-40 138.7 0.1 1.3 1 0 0 1 1 1 1 YjeF-related protein N-terminus FDF PF09532.10 CCF44442.1 - 3.8e-08 34.2 2.6 3.8e-08 34.2 2.6 2.5 2 1 0 2 2 2 1 FDF domain PIF1 PF05970.14 CCF44443.1 - 8.6e-60 202.8 0.1 2.2e-46 158.7 0.0 2.2 1 1 0 2 2 2 2 PIF1-like helicase AAA_30 PF13604.6 CCF44443.1 - 3.3e-21 75.9 0.0 6e-21 75.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CCF44443.1 - 1.9e-11 44.5 0.0 4.1e-11 43.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CCF44443.1 - 2.9e-05 24.4 0.0 8.1e-05 22.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 CCF44443.1 - 6.3e-05 22.6 0.0 0.00012 21.6 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region Herpes_Helicase PF02689.14 CCF44443.1 - 0.00028 19.0 0.0 0.00082 17.4 0.0 1.6 2 0 0 2 2 2 1 Helicase UvrD_C_2 PF13538.6 CCF44443.1 - 0.00048 19.9 0.0 0.0013 18.5 0.0 1.8 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_16 PF13191.6 CCF44443.1 - 0.00064 20.2 0.0 0.0015 18.9 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 CCF44443.1 - 0.0016 18.9 0.0 0.004 17.6 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 CCF44443.1 - 0.0019 18.7 0.0 0.0065 17.0 0.0 1.9 1 0 0 1 1 1 1 ABC transporter PhoH PF02562.16 CCF44443.1 - 0.0039 16.7 0.1 0.021 14.3 0.0 2.2 3 0 0 3 3 2 1 PhoH-like protein AFG1_ATPase PF03969.16 CCF44443.1 - 0.0079 15.1 0.1 0.015 14.2 0.1 1.4 1 0 0 1 1 1 1 AFG1-like ATPase T2SSE PF00437.20 CCF44443.1 - 0.01 14.9 0.0 0.017 14.2 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein RNA_helicase PF00910.22 CCF44443.1 - 0.011 16.1 0.0 0.036 14.4 0.0 1.9 1 0 0 1 1 1 0 RNA helicase SH3_13 PF18335.1 CCF44443.1 - 0.017 15.0 0.1 0.077 12.8 0.0 2.1 2 0 0 2 2 1 0 ATP-dependent RecD-like DNA helicase SH3 domain NACHT PF05729.12 CCF44443.1 - 0.023 14.6 0.0 0.047 13.6 0.0 1.5 1 0 0 1 1 1 0 NACHT domain RsgA_GTPase PF03193.16 CCF44443.1 - 0.03 14.2 0.1 0.063 13.2 0.1 1.5 1 0 0 1 1 1 0 RsgA GTPase NB-ARC PF00931.22 CCF44443.1 - 0.044 13.0 0.0 0.076 12.2 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_5 PF07728.14 CCF44443.1 - 0.047 13.7 0.1 0.44 10.5 0.1 2.4 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) DUF2075 PF09848.9 CCF44443.1 - 0.048 12.9 0.0 0.12 11.6 0.0 1.7 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_11 PF13086.6 CCF44443.1 - 0.051 13.4 2.9 0.11 12.3 0.0 2.7 1 1 1 3 3 3 0 AAA domain ATPase_2 PF01637.18 CCF44443.1 - 0.057 13.3 0.2 0.17 11.8 0.0 1.9 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_29 PF13555.6 CCF44443.1 - 0.064 13.0 0.0 0.15 11.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Viral_helicase1 PF01443.18 CCF44443.1 - 0.065 13.0 0.2 4.8 6.9 0.0 2.9 2 1 0 2 2 2 0 Viral (Superfamily 1) RNA helicase ResIII PF04851.15 CCF44443.1 - 0.09 12.8 0.1 0.18 11.8 0.1 1.5 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_14 PF13173.6 CCF44443.1 - 0.1 12.6 0.0 0.48 10.5 0.0 2.1 1 1 0 1 1 1 0 AAA domain DUF5605 PF18310.1 CCF44443.1 - 0.12 12.2 0.6 17 5.4 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF5605) NTPase_1 PF03266.15 CCF44443.1 - 0.16 11.9 0.0 0.51 10.2 0.0 1.9 1 0 0 1 1 1 0 NTPase COPIIcoated_ERV PF07970.12 CCF44444.1 - 2.8 7.7 5.3 0.37 10.6 1.0 1.6 2 0 0 2 2 2 0 Endoplasmic reticulum vesicle transporter Hce2 PF14856.6 CCF44445.1 - 1.5e-12 47.7 0.3 2.9e-12 46.8 0.1 1.5 2 0 0 2 2 2 1 Pathogen effector; putative necrosis-inducing factor COesterase PF00135.28 CCF44446.1 - 1.8e-72 244.9 0.0 1e-71 242.4 0.0 2.0 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CCF44446.1 - 5.2e-06 26.5 0.1 2e-05 24.5 0.1 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CCF44446.1 - 0.011 15.2 0.2 0.021 14.3 0.2 1.4 1 0 0 1 1 1 0 Prolyl oligopeptidase family CH PF00307.31 CCF44447.1 - 1.1e-12 48.1 0.0 2.2e-12 47.1 0.0 1.6 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 CCF44447.1 - 0.12 12.2 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 CAMSAP CH domain Csc2 PF18320.1 CCF44447.1 - 2.5 7.0 6.5 3.9 6.4 6.5 1.2 1 0 0 1 1 1 0 Csc2 Crispr NDUFA12 PF05071.16 CCF44448.1 - 1e-09 39.1 0.1 1e-09 39.1 0.1 2.2 1 1 0 2 2 2 1 NADH ubiquinone oxidoreductase subunit NDUFA12 cwf21 PF08312.12 CCF44449.1 - 7.6e-17 61.2 12.4 2.2e-16 59.7 12.4 1.8 1 0 0 1 1 1 1 cwf21 domain GvpG PF05120.12 CCF44449.1 - 0.85 9.7 11.6 1.7 8.7 3.6 2.3 1 1 1 2 2 2 0 Gas vesicle protein G D123 PF07065.14 CCF44450.1 - 3.7e-115 384.3 0.0 4.4e-115 384.1 0.0 1.0 1 0 0 1 1 1 1 D123 DUF3716 PF12511.8 CCF44451.1 - 1.3e-16 60.3 9.8 2e-16 59.7 9.8 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3716) SARAF PF06682.12 CCF44451.1 - 0.12 12.0 3.4 0.2 11.3 3.4 1.3 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis DUF3517 PF12030.8 CCF44451.1 - 0.21 10.5 0.0 0.33 9.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3517) NicO PF03824.16 CCF44451.1 - 2.2 7.6 4.1 3.3 7.0 4.1 1.3 1 0 0 1 1 1 0 High-affinity nickel-transport protein Tfb2_C PF18307.1 CCF44454.1 - 2.7e-22 79.0 0.3 4.3e-22 78.3 0.1 1.5 2 0 0 2 2 2 1 Transcription factor Tfb2 (p52) C-terminal domain Tfb2 PF03849.14 CCF44454.1 - 2.8e-12 46.3 0.1 4e-12 45.8 0.1 1.2 1 0 0 1 1 1 1 Transcription factor Tfb2 Helicase_C_3 PF13625.6 CCF44454.1 - 2.8e-05 24.3 0.1 5.2e-05 23.4 0.1 1.7 1 1 0 1 1 1 1 Helicase conserved C-terminal domain LANC_like PF05147.13 CCF44454.1 - 0.17 10.4 0.0 0.21 10.1 0.0 1.1 1 0 0 1 1 1 0 Lanthionine synthetase C-like protein DHC_N1 PF08385.12 CCF44456.1 - 1.2e-44 152.9 12.6 1.6e-44 152.6 0.1 3.1 2 1 1 3 3 3 1 Dynein heavy chain, N-terminal region 1 DHC_N2 PF08393.13 CCF44456.1 - 6.5e-20 71.6 0.4 6.5e-20 71.6 0.4 4.5 3 2 1 4 4 4 2 Dynein heavy chain, N-terminal region 2 DUF2894 PF11445.8 CCF44456.1 - 0.0055 17.2 0.4 0.64 10.5 0.4 3.4 2 1 0 2 2 2 1 Protein of unknown function (DUF2894) IL32 PF15225.6 CCF44456.1 - 0.049 14.0 2.2 0.45 10.9 0.0 3.5 3 1 0 3 3 3 0 Interleukin 32 COG2 PF06148.11 CCF44456.1 - 0.59 10.2 0.0 0.59 10.2 0.0 5.3 5 2 0 5 5 5 0 COG (conserved oligomeric Golgi) complex component, COG2 HrpB7 PF09486.10 CCF44456.1 - 0.94 9.9 6.9 0.77 10.1 0.3 2.8 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) NPV_P10 PF05531.12 CCF44456.1 - 8.2 7.0 10.1 37 4.9 0.1 5.4 4 1 1 5 5 5 0 Nucleopolyhedrovirus P10 protein FAD_binding_3 PF01494.19 CCF44457.1 - 8e-13 48.4 0.0 1.2e-12 47.8 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain SE PF08491.10 CCF44457.1 - 0.012 14.7 0.0 0.026 13.6 0.0 1.5 1 0 0 1 1 1 0 Squalene epoxidase YjbR PF04237.13 CCF44457.1 - 0.11 13.1 0.0 0.45 11.1 0.0 2.0 1 1 1 2 2 2 0 YjbR Clr5 PF14420.6 CCF44458.1 - 0.0001 22.4 0.4 0.00028 21.0 0.4 1.8 1 0 0 1 1 1 1 Clr5 domain TPR_12 PF13424.6 CCF44458.1 - 0.00032 20.9 4.8 0.00062 20.0 0.4 3.2 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 CCF44458.1 - 0.008 16.1 1.0 23 5.3 0.0 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 CCF44458.1 - 0.081 13.1 0.1 17 5.8 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 CCF44458.1 - 0.17 11.7 0.2 30 4.7 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.6 CCF44458.1 - 0.25 11.9 1.2 1 9.9 0.1 2.5 2 1 0 2 2 2 0 Tetratricopeptide repeat p450 PF00067.22 CCF44459.1 - 4.6e-92 309.2 0.0 5.4e-92 309.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 AAL_decarboxy PF03306.13 CCF44460.1 - 3.5e-76 255.4 0.0 3.9e-76 255.2 0.0 1.0 1 0 0 1 1 1 1 Alpha-acetolactate decarboxylase MFS_1 PF07690.16 CCF44463.1 - 6.7e-31 107.5 32.0 1e-30 106.9 32.0 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 CCF44463.1 - 3.1e-06 26.7 5.7 3.1e-06 26.7 5.7 2.3 2 0 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB Adeno_E3_15_3 PF03307.14 CCF44464.1 - 0.12 12.4 0.0 0.14 12.1 0.0 1.1 1 0 0 1 1 1 0 Adenovirus 15.3kD protein in E3 region NAAA-beta PF15508.6 CCF44465.1 - 1.1e-15 57.6 0.0 2e-15 56.8 0.0 1.4 1 0 0 1 1 1 1 beta subunit of N-acylethanolamine-hydrolyzing acid amidase p450 PF00067.22 CCF44466.1 - 8.9e-55 186.3 0.0 1.5e-54 185.5 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 Iso_dh PF00180.20 CCF44467.1 - 8.2e-82 275.1 0.0 9.4e-82 274.9 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase MFS_1 PF07690.16 CCF44469.1 - 4.4e-12 45.6 26.2 5.1e-12 45.4 26.2 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily TPR_16 PF13432.6 CCF44472.1 - 3.1e-06 27.7 0.5 0.32 11.7 0.0 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 CCF44472.1 - 0.0012 18.8 0.6 24 5.3 0.1 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_12 PF13424.6 CCF44472.1 - 0.012 15.9 0.4 1.7 9.0 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 CCF44472.1 - 0.04 14.8 7.4 1e+02 4.2 0.0 6.1 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_8 PF13181.6 CCF44472.1 - 0.045 14.0 0.6 12 6.4 0.0 4.1 5 0 0 5 5 5 0 Tetratricopeptide repeat ANAPC3 PF12895.7 CCF44472.1 - 0.053 13.7 0.2 11 6.4 0.0 3.1 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 SOBP PF15279.6 CCF44472.1 - 1.4 9.4 8.7 2.3 8.8 8.7 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein Mucin PF01456.17 CCF44472.1 - 7.3 6.6 12.7 17 5.4 12.7 1.6 1 0 0 1 1 1 0 Mucin-like glycoprotein TPP_enzyme_N PF02776.18 CCF44473.1 - 1.2e-29 103.1 5.0 8.3e-18 64.6 0.4 2.6 2 1 1 3 3 3 2 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 CCF44473.1 - 2.6e-23 82.3 0.0 4e-23 81.7 0.0 1.3 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain PDR_CDR PF06422.12 CCF44474.1 - 0.046 13.6 0.1 0.084 12.8 0.1 1.5 1 0 0 1 1 1 0 CDR ABC transporter Glyco_hydro_100 PF12899.7 CCF44474.1 - 0.09 11.4 0.0 0.11 11.1 0.0 1.1 1 0 0 1 1 1 0 Alkaline and neutral invertase MoeA_N PF03453.17 CCF44475.1 - 2.1e-34 118.5 0.9 3e-34 118.0 0.9 1.2 1 0 0 1 1 1 1 MoeA N-terminal region (domain I and II) MoCF_biosynth PF00994.24 CCF44475.1 - 3.7e-31 107.7 0.0 1.7e-30 105.5 0.0 1.9 2 0 0 2 2 2 1 Probable molybdopterin binding domain 7TMR-HDED PF07697.11 CCF44475.1 - 0.24 11.5 0.0 0.41 10.7 0.0 1.3 1 0 0 1 1 1 0 7TM-HD extracellular TPT PF03151.16 CCF44476.1 - 1.6e-26 93.3 26.9 2e-26 93.0 26.9 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 CCF44476.1 - 0.00015 21.9 39.6 0.01 16.0 14.7 2.4 3 0 0 3 3 3 2 EamA-like transporter family Mito_carr PF00153.27 CCF44477.1 - 8.5e-56 185.9 0.1 1.3e-19 69.9 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Peptidase_C2 PF00648.21 CCF44479.1 - 3.3e-30 105.1 0.0 5.2e-30 104.5 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.22 CCF44479.1 - 1.8e-09 38.0 0.0 3.6e-06 27.3 0.0 3.6 2 1 0 2 2 2 1 Calpain large subunit, domain III ssDBP PF17878.1 CCF44479.1 - 0.01 16.1 0.0 0.029 14.6 0.0 1.7 1 0 0 1 1 1 0 Single-stranded DNA-binding protein zf-C2H2 PF00096.26 CCF44480.1 - 1.1e-06 28.7 11.9 0.0051 17.2 2.0 3.7 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CCF44480.1 - 0.00098 19.5 7.6 0.7 10.4 0.2 3.5 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 CCF44480.1 - 0.039 14.8 10.7 0.11 13.4 1.7 3.6 3 0 0 3 3 3 0 C2H2-type zinc finger zf-Di19 PF05605.12 CCF44480.1 - 1.9 8.9 5.0 0.45 10.8 0.9 2.0 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding DUF3665 PF12427.8 CCF44480.1 - 9.2 6.1 6.0 42 3.9 0.2 2.5 2 0 0 2 2 2 0 Branched-chain amino acid aminotransferase Cupin_2 PF07883.11 CCF44481.1 - 1.4e-07 31.1 0.1 2.5e-07 30.3 0.1 1.4 1 0 0 1 1 1 1 Cupin domain Cupin_3 PF05899.12 CCF44481.1 - 0.096 12.4 0.1 0.16 11.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF861) Peptidase_M22 PF00814.25 CCF44482.1 - 2.2e-85 286.7 0.0 2.6e-85 286.4 0.0 1.0 1 0 0 1 1 1 1 Glycoprotease family Carbam_trans_N PF02543.15 CCF44482.1 - 0.042 13.5 0.0 0.22 11.2 0.0 1.9 2 0 0 2 2 2 0 Carbamoyltransferase N-terminus AMPKBI PF04739.15 CCF44483.1 - 8.5e-26 90.0 1.9 1.7e-25 89.1 1.9 1.5 1 0 0 1 1 1 1 5'-AMP-activated protein kinase beta subunit, interaction domain AMPK1_CBM PF16561.5 CCF44483.1 - 0.024 14.9 0.0 0.053 13.8 0.0 1.6 1 0 0 1 1 1 0 Glycogen recognition site of AMP-activated protein kinase TF_Zn_Ribbon PF08271.12 CCF44484.1 - 0.031 13.8 0.0 0.048 13.2 0.0 1.2 1 0 0 1 1 1 0 TFIIB zinc-binding Mito_fiss_reg PF05308.11 CCF44484.1 - 5.7 6.9 8.7 1.3 9.0 0.2 2.0 1 1 1 2 2 2 0 Mitochondrial fission regulator FGGY_C PF02782.16 CCF44486.1 - 6.1e-72 241.5 0.7 1.1e-71 240.7 0.7 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 CCF44486.1 - 8.7e-66 222.0 0.0 1.1e-65 221.6 0.0 1.1 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain BcrAD_BadFG PF01869.20 CCF44486.1 - 0.015 14.8 0.1 0.28 10.6 0.0 2.2 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family HTH_IclR PF09339.10 CCF44486.1 - 0.12 12.2 0.1 0.68 9.8 0.0 2.3 2 0 0 2 2 2 0 IclR helix-turn-helix domain WAPL PF07814.13 CCF44487.1 - 4.8e-54 183.5 0.0 7.1e-54 183.0 0.0 1.2 1 0 0 1 1 1 1 Wings apart-like protein regulation of heterochromatin Fun_ATP-synt_8 PF05933.13 CCF44487.1 - 0.023 14.8 0.3 0.042 14.0 0.3 1.3 1 0 0 1 1 1 0 Fungal ATP synthase protein 8 (A6L) UPRTase PF14681.6 CCF44488.1 - 2.5e-80 268.8 0.0 3e-80 268.6 0.0 1.1 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 CCF44488.1 - 0.004 16.7 0.0 0.0062 16.1 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Elf1 PF05129.13 CCF44489.1 - 8e-29 99.5 0.2 1e-28 99.2 0.2 1.1 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like PHD_4 PF16866.5 CCF44489.1 - 0.046 13.8 0.4 0.075 13.1 0.4 1.4 1 0 0 1 1 1 0 PHD-finger GTP_CH_N PF12471.8 CCF44490.1 - 8.7e-86 286.6 0.0 1.2e-85 286.2 0.0 1.2 1 0 0 1 1 1 1 GTP cyclohydrolase N terminal GTP_cyclohydro2 PF00925.20 CCF44490.1 - 2e-17 63.2 0.0 3.2e-17 62.6 0.0 1.3 1 0 0 1 1 1 1 GTP cyclohydrolase II Snapin_Pallidin PF14712.6 CCF44490.1 - 0.18 12.2 0.0 0.44 11.0 0.0 1.6 1 0 0 1 1 1 0 Snapin/Pallidin DUF4965 PF16335.5 CCF44491.1 - 2.9e-52 176.8 0.0 5.2e-52 176.0 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4965) DUF5127 PF17168.4 CCF44491.1 - 1.2e-31 110.2 0.3 1.9e-31 109.6 0.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF5127) FMN_dh PF01070.18 CCF44493.1 - 3.6e-70 236.7 3.9 4.1e-70 236.5 3.9 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.25 CCF44493.1 - 8e-11 41.5 0.6 2.3e-10 40.0 0.1 1.9 2 0 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.15 CCF44493.1 - 5.6e-09 35.8 0.3 6.9e-09 35.5 0.3 1.1 1 0 0 1 1 1 1 Nitronate monooxygenase Glu_synthase PF01645.17 CCF44493.1 - 2.2e-06 27.0 0.7 4.7e-06 26.0 0.7 1.6 1 1 0 1 1 1 1 Conserved region in glutamate synthase ThiG PF05690.14 CCF44493.1 - 4e-06 26.3 0.9 0.0018 17.6 0.1 2.2 1 1 1 2 2 2 2 Thiazole biosynthesis protein ThiG DHO_dh PF01180.21 CCF44493.1 - 7e-06 25.5 0.4 0.00012 21.4 0.0 2.0 1 1 1 2 2 2 1 Dihydroorotate dehydrogenase His_biosynth PF00977.21 CCF44493.1 - 1.3e-05 24.7 0.4 0.0037 16.8 0.0 2.3 1 1 1 2 2 2 2 Histidine biosynthesis protein G3P_antiterm PF04309.12 CCF44493.1 - 0.0013 18.1 0.1 0.82 9.1 0.0 2.3 2 0 0 2 2 2 2 Glycerol-3-phosphate responsive antiterminator Dus PF01207.17 CCF44493.1 - 0.002 17.3 0.1 0.0042 16.2 0.1 1.6 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) PcrB PF01884.17 CCF44493.1 - 0.046 13.2 0.1 2.7 7.4 0.0 2.1 2 0 0 2 2 2 0 PcrB family Ribul_P_3_epim PF00834.19 CCF44493.1 - 0.083 12.3 0.6 5.1 6.4 0.0 2.1 1 1 1 2 2 2 0 Ribulose-phosphate 3 epimerase family IGPS PF00218.21 CCF44493.1 - 0.17 11.0 0.0 1.9 7.6 0.1 2.0 1 1 1 2 2 2 0 Indole-3-glycerol phosphate synthase MFS_1 PF07690.16 CCF44494.1 - 2.4e-32 112.2 34.5 2.8e-32 112.0 34.5 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 CCF44494.1 - 2.9e-06 26.8 8.1 2.9e-06 26.8 8.1 3.0 2 1 1 3 3 3 3 Uncharacterised MFS-type transporter YbfB Aim21 PF11489.8 CCF44496.1 - 1.6e-113 381.1 54.9 1.6e-113 381.1 54.9 2.1 2 0 0 2 2 2 1 Altered inheritance of mitochondria protein 21 Glyco_hydro_10 PF00331.20 CCF44497.1 - 3.6e-89 299.1 0.0 4.1e-89 298.8 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 POT1 PF02765.17 CCF44498.1 - 6.5e-13 48.7 0.0 7.3e-13 48.6 0.0 1.0 1 0 0 1 1 1 1 Telomeric single stranded DNA binding POT1/CDC13 SIR2 PF02146.17 CCF44499.1 - 1.5e-24 86.9 0.0 3.9e-24 85.5 0.0 1.7 1 1 0 1 1 1 1 Sir2 family SNF2_N PF00176.23 CCF44500.1 - 7.1e-55 186.1 0.1 1.2e-54 185.4 0.1 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Chromo PF00385.24 CCF44500.1 - 3.1e-24 84.6 7.3 1.1e-15 57.2 1.1 3.0 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Helicase_C PF00271.31 CCF44500.1 - 7.2e-20 71.4 0.0 1.8e-19 70.1 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4208 PF13907.6 CCF44500.1 - 9.4e-17 61.2 0.0 3.1e-16 59.6 0.0 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4208) HDA2-3 PF11496.8 CCF44500.1 - 1.7e-08 34.0 0.0 4.7e-08 32.5 0.0 1.7 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.15 CCF44500.1 - 1.5e-06 28.3 0.0 9e-06 25.8 0.0 2.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Cdh1_DBD_1 PF18196.1 CCF44500.1 - 1.9e-05 24.9 0.2 1.9e-05 24.9 0.2 4.5 3 1 1 4 4 4 2 Chromodomain helicase DNA-binding domain 1 CDH1_2_SANT_HL1 PF18375.1 CCF44500.1 - 0.00074 20.1 1.1 0.00074 20.1 1.1 2.7 2 0 0 2 2 1 1 CDH1/2 SANT-Helical linker 1 AAA_22 PF13401.6 CCF44500.1 - 0.0039 17.5 0.0 0.014 15.6 0.0 2.0 1 0 0 1 1 1 1 AAA domain SLIDE PF09111.10 CCF44500.1 - 0.006 16.6 2.9 0.038 14.0 0.1 3.2 2 0 0 2 2 2 1 SLIDE CHDCT2 PF08074.11 CCF44500.1 - 0.032 14.4 0.2 0.24 11.6 0.0 2.5 2 0 0 2 2 2 0 CHDCT2 (NUC038) domain Pkinase PF00069.25 CCF44501.1 - 8.9e-36 123.6 0.0 8.6e-35 120.4 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF44501.1 - 2.3e-17 63.1 0.0 1.9e-09 37.2 0.0 3.1 3 0 0 3 3 3 3 Protein tyrosine kinase GST_C_2 PF13410.6 CCF44503.1 - 0.0053 16.8 0.0 0.0074 16.3 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Chitin_synth_2 PF03142.15 CCF44504.1 - 1.3e-180 601.6 8.5 3.5e-180 600.1 9.3 1.3 2 0 0 2 2 2 1 Chitin synthase DEK_C PF08766.11 CCF44504.1 - 6.2e-18 64.5 0.0 5e-17 61.6 0.1 2.2 2 0 0 2 2 2 1 DEK C terminal domain Glyco_trans_2_3 PF13632.6 CCF44504.1 - 2e-12 47.5 8.2 5e-12 46.1 8.2 1.7 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 CCF44504.1 - 3.5e-10 40.2 0.1 8.6e-10 38.9 0.1 1.7 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 CCF44504.1 - 0.00026 20.8 0.0 0.00051 19.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 CCF44504.1 - 0.019 14.5 0.5 0.28 10.6 0.5 2.2 1 1 0 1 1 1 0 Glycosyl transferase family 21 RTA1 PF04479.13 CCF44505.1 - 4.3e-64 215.9 11.1 5.3e-64 215.6 11.1 1.0 1 0 0 1 1 1 1 RTA1 like protein RNR_Alpha PF17975.1 CCF44507.1 - 0.015 15.8 0.3 1.5 9.4 0.1 2.3 2 0 0 2 2 2 0 Ribonucleotide reductase alpha domain Exo_endo_phos PF03372.23 CCF44507.1 - 0.022 14.3 0.1 0.033 13.7 0.1 1.1 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family SF1-HH PF16275.5 CCF44509.1 - 2.1e-43 147.2 0.7 2.1e-43 147.2 0.7 2.6 1 1 1 2 2 2 1 Splicing factor 1 helix-hairpin domain zf-CCHC PF00098.23 CCF44509.1 - 6.4e-12 45.0 11.1 1.3e-05 25.0 0.8 2.4 2 0 0 2 2 2 2 Zinc knuckle KH_1 PF00013.29 CCF44509.1 - 6.2e-08 32.4 0.2 1.1e-07 31.5 0.2 1.4 1 0 0 1 1 1 1 KH domain zf-CCHC_3 PF13917.6 CCF44509.1 - 9e-07 28.8 6.4 0.00043 20.2 3.1 2.6 1 1 1 2 2 2 2 Zinc knuckle zf-CCHC_6 PF15288.6 CCF44509.1 - 0.0003 20.6 7.2 0.11 12.4 0.3 2.8 1 1 1 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 CCF44509.1 - 0.00099 18.8 4.9 0.42 10.4 0.4 2.5 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_2 PF13696.6 CCF44509.1 - 0.014 15.2 0.5 0.014 15.2 0.5 2.4 2 0 0 2 2 2 0 Zinc knuckle PHD_4 PF16866.5 CCF44509.1 - 0.35 11.0 2.3 0.77 9.9 2.3 1.5 1 0 0 1 1 1 0 PHD-finger Peptidase_M16_C PF05193.21 CCF44509.1 - 0.89 9.5 2.2 7.4 6.5 0.2 2.4 2 1 0 2 2 2 0 Peptidase M16 inactive domain MFS_1 PF07690.16 CCF44510.1 - 8.3e-19 67.7 12.3 1.1e-18 67.4 12.3 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily CENP-B_N PF04218.13 CCF44510.1 - 0.0021 17.6 0.0 0.0042 16.7 0.0 1.4 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain Trp_oprn_chp PF09534.10 CCF44510.1 - 0.59 9.9 7.5 4.4 7.1 1.9 2.8 1 1 2 3 3 3 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Pro_isomerase PF00160.21 CCF44512.1 - 4.6e-35 121.2 0.1 1e-34 120.1 0.1 1.6 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Fungal_trans_2 PF11951.8 CCF44513.1 - 2.3e-45 155.1 0.0 3e-45 154.7 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Sin3_corepress PF08295.12 CCF44513.1 - 0.1 12.7 0.0 0.25 11.4 0.0 1.6 1 0 0 1 1 1 0 Sin3 family co-repressor Ferritin_2 PF13668.6 CCF44514.1 - 1.7e-40 138.3 0.8 2.7e-40 137.7 0.8 1.3 1 0 0 1 1 1 1 Ferritin-like domain FMN_dh PF01070.18 CCF44515.1 - 7.4e-118 393.6 0.0 8.5e-118 393.4 0.0 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Glu_synthase PF01645.17 CCF44515.1 - 2.5e-05 23.6 0.3 3.7e-05 23.0 0.3 1.1 1 0 0 1 1 1 1 Conserved region in glutamate synthase NMO PF03060.15 CCF44515.1 - 8.6e-05 22.1 1.1 0.00014 21.4 1.1 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 CCF44515.1 - 9.6e-05 21.5 0.6 0.0005 19.2 0.5 1.9 2 0 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain ThiG PF05690.14 CCF44515.1 - 0.0024 17.2 0.5 0.085 12.2 0.5 2.2 2 0 0 2 2 2 1 Thiazole biosynthesis protein ThiG His_biosynth PF00977.21 CCF44515.1 - 0.0098 15.4 0.2 0.04 13.4 0.0 1.9 1 1 1 2 2 2 1 Histidine biosynthesis protein SLD5_C PF16922.5 CCF44516.1 - 7.2e-14 51.7 0.2 1.2e-13 51.0 0.2 1.4 1 0 0 1 1 1 1 DNA replication complex GINS protein SLD5 C-terminus Sld5 PF05916.11 CCF44516.1 - 5.7e-07 30.0 0.4 1.7e-06 28.5 0.3 1.8 1 1 1 2 2 2 1 GINS complex protein DUF896 PF05979.12 CCF44516.1 - 0.086 12.7 0.0 0.22 11.4 0.0 1.7 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF896) Sugar_tr PF00083.24 CCF44518.1 - 2.9e-24 85.8 8.3 3.2e-24 85.6 8.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF44518.1 - 3.8e-12 45.8 10.6 4.5e-12 45.6 10.6 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.6 CCF44518.1 - 0.0063 15.1 2.8 0.0072 14.9 2.8 1.1 1 0 0 1 1 1 1 MFS/sugar transport protein TRI12 PF06609.13 CCF44518.1 - 0.036 12.5 2.2 0.038 12.4 2.2 1.1 1 0 0 1 1 1 0 Fungal trichothecene efflux pump (TRI12) Acyl_transf_3 PF01757.22 CCF44518.1 - 0.085 11.9 6.0 0.14 11.2 6.0 1.4 1 1 0 1 1 1 0 Acyltransferase family p450 PF00067.22 CCF44519.1 - 1.1e-17 64.0 0.0 4.6e-17 61.9 0.0 1.7 1 1 0 1 1 1 1 Cytochrome P450 Hira PF07569.11 CCF44519.1 - 0.12 12.0 0.0 0.18 11.5 0.0 1.2 1 0 0 1 1 1 0 TUP1-like enhancer of split RTC PF01137.21 CCF44521.1 - 5.5e-46 156.5 0.0 7.7e-46 156.1 0.0 1.3 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase DUF2561 PF10812.8 CCF44522.1 - 0.054 13.5 0.1 0.054 13.5 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2561) MRP-63 PF14978.6 CCF44522.1 - 0.13 12.9 0.0 0.23 12.1 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosome protein 63 Pho88 PF10032.9 CCF44523.1 - 6e-72 240.7 0.0 6.7e-72 240.6 0.0 1.0 1 0 0 1 1 1 1 Phosphate transport (Pho88) XPA_C PF05181.12 CCF44524.1 - 7.5e-26 89.9 2.4 1.7e-25 88.7 2.4 1.7 1 0 0 1 1 1 1 XPA protein C-terminus XPA_N PF01286.18 CCF44524.1 - 0.00014 21.8 1.6 0.00028 20.8 1.6 1.5 1 0 0 1 1 1 1 XPA protein N-terminal ArfGap PF01412.18 CCF44524.1 - 0.011 15.8 0.5 0.022 14.8 0.5 1.4 1 0 0 1 1 1 0 Putative GTPase activating protein for Arf NMD3 PF04981.13 CCF44524.1 - 0.13 11.7 0.1 0.18 11.2 0.1 1.2 1 0 0 1 1 1 0 NMD3 family XFP_C PF09363.10 CCF44525.1 - 1.3e-78 263.1 0.0 1.5e-78 262.9 0.0 1.1 1 0 0 1 1 1 1 XFP C-terminal domain XFP PF03894.15 CCF44525.1 - 8.3e-35 120.1 0.1 1.2e-34 119.5 0.1 1.3 1 0 0 1 1 1 1 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase Transketolase_C PF02780.20 CCF44525.1 - 0.021 14.7 0.1 0.051 13.4 0.1 1.6 1 0 0 1 1 1 0 Transketolase, C-terminal domain RabGAP-TBC PF00566.18 CCF44527.1 - 4.9e-46 157.1 1.1 1.4e-45 155.5 0.0 2.1 2 0 0 2 2 1 1 Rab-GTPase-TBC domain DUF4686 PF15742.5 CCF44527.1 - 0.00061 19.0 9.6 0.00061 19.0 9.6 2.4 3 0 0 3 3 2 1 Domain of unknown function (DUF4686) Fez1 PF06818.15 CCF44527.1 - 0.002 18.6 20.8 0.085 13.3 0.8 3.1 2 1 0 2 2 2 2 Fez1 CCDC144C PF14915.6 CCF44527.1 - 0.0084 15.3 16.4 0.036 13.2 3.4 2.8 3 0 0 3 3 3 2 CCDC144C protein coiled-coil region zf-C4H2 PF10146.9 CCF44527.1 - 0.012 15.9 8.8 0.012 15.9 8.8 2.6 2 1 0 2 2 2 0 Zinc finger-containing protein DUF1465 PF07323.12 CCF44527.1 - 0.026 14.4 11.8 0.18 11.6 3.8 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1465) APG6_N PF17675.1 CCF44527.1 - 0.031 14.8 30.8 2.9 8.4 0.1 3.6 2 1 1 3 3 3 0 Apg6 coiled-coil region Cnn_1N PF07989.11 CCF44527.1 - 0.061 13.5 19.0 3.8 7.7 0.0 4.4 3 1 1 4 4 4 0 Centrosomin N-terminal motif 1 SKA1 PF07160.12 CCF44527.1 - 0.096 12.5 9.1 2.8 7.7 0.3 2.6 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 FapA PF03961.13 CCF44527.1 - 0.22 10.1 8.3 0.19 10.3 1.7 2.3 2 0 0 2 2 2 0 Flagellar Assembly Protein A SKA2 PF16740.5 CCF44527.1 - 0.23 11.2 14.6 3.2 7.6 6.8 2.7 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 Spc7 PF08317.11 CCF44527.1 - 0.52 9.2 24.2 0.19 10.6 6.8 3.1 3 0 0 3 3 3 0 Spc7 kinetochore protein Rootletin PF15035.6 CCF44527.1 - 0.7 9.9 21.1 0.058 13.4 5.1 2.8 3 0 0 3 3 2 0 Ciliary rootlet component, centrosome cohesion V_ATPase_I PF01496.19 CCF44527.1 - 0.81 7.5 10.9 0.16 9.9 2.6 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Filament PF00038.21 CCF44527.1 - 1.1 8.8 21.3 0.04 13.5 6.0 2.6 3 0 0 3 3 3 0 Intermediate filament protein Macoilin PF09726.9 CCF44527.1 - 1.3 7.5 20.7 0.86 8.1 3.1 2.3 2 0 0 2 2 2 0 Macoilin family Scaffolding_pro PF11418.8 CCF44527.1 - 1.4 9.5 7.1 16 6.1 1.3 3.3 3 0 0 3 3 3 0 Phi29 scaffolding protein DUF4763 PF15960.5 CCF44527.1 - 1.4 8.2 17.1 3.6 6.8 5.9 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4763) ATG16 PF08614.11 CCF44527.1 - 1.6 8.9 36.9 0.72 10.0 12.6 3.2 2 1 0 3 3 3 0 Autophagy protein 16 (ATG16) Tup_N PF08581.10 CCF44527.1 - 2 8.8 16.7 1.3 9.4 7.6 2.8 2 0 0 2 2 2 0 Tup N-terminal Sigma70_ner PF04546.13 CCF44527.1 - 3.4 7.5 15.1 0.71 9.7 9.8 2.4 2 0 0 2 2 2 0 Sigma-70, non-essential region DUF724 PF05266.14 CCF44527.1 - 3.7 7.3 21.6 0.091 12.6 6.8 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF724) Cob_adeno_trans PF01923.18 CCF44527.1 - 5.3 7.1 8.0 0.55 10.3 0.7 2.6 3 0 0 3 3 2 0 Cobalamin adenosyltransferase CENP-F_leu_zip PF10473.9 CCF44527.1 - 5.6 7.0 30.2 0.085 12.9 6.7 3.5 4 0 0 4 4 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Ax_dynein_light PF10211.9 CCF44527.1 - 6.1 6.7 22.7 0.36 10.7 1.1 3.2 3 1 0 3 3 3 0 Axonemal dynein light chain CHD5 PF04420.14 CCF44527.1 - 6.2 6.7 13.0 9.1 6.1 2.0 2.8 2 0 0 2 2 2 0 CHD5-like protein TipAS PF07739.13 CCF44527.1 - 7.4 7.2 11.9 1.8 9.1 1.0 3.6 3 1 0 3 3 3 0 TipAS antibiotic-recognition domain ADIP PF11559.8 CCF44527.1 - 8 6.5 30.2 0.36 10.9 8.8 3.2 3 0 0 3 3 3 0 Afadin- and alpha -actinin-Binding End3 PF12761.7 CCF44527.1 - 8 6.6 22.4 2.6 8.2 4.3 3.3 2 1 1 3 3 3 0 Actin cytoskeleton-regulatory complex protein END3 EMP24_GP25L PF01105.24 CCF44527.1 - 8.1 6.3 14.4 4.7 7.1 0.8 2.7 2 1 0 2 2 2 0 emp24/gp25L/p24 family/GOLD Occludin_ELL PF07303.13 CCF44527.1 - 8.4 7.2 12.8 8.1 7.2 0.7 3.1 3 0 0 3 3 2 0 Occludin homology domain Aminotran_1_2 PF00155.21 CCF44528.1 - 6.9e-37 127.5 0.0 8e-37 127.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 CCF44528.1 - 0.0018 16.9 0.0 0.0032 16.1 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme OKR_DC_1 PF01276.20 CCF44528.1 - 0.066 11.9 0.0 1 8.0 0.0 2.4 2 1 0 2 2 2 0 Orn/Lys/Arg decarboxylase, major domain SnAPC_2_like PF11035.8 CCF44528.1 - 0.079 13.1 0.1 0.12 12.5 0.1 1.2 1 0 0 1 1 1 0 Small nuclear RNA activating complex subunit 2, SNAP190 Myb Mannosyl_trans3 PF11051.8 CCF44529.1 - 3.2e-26 92.3 0.1 6.9e-18 65.0 0.0 2.1 1 1 1 2 2 2 2 Mannosyltransferase putative AMP-binding PF00501.28 CCF44530.1 - 4.3e-63 213.4 0.0 5.1e-63 213.1 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CCF44530.1 - 5e-05 24.2 0.0 9.3e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Response_reg PF00072.24 CCF44531.1 - 9.6e-09 35.4 0.0 1.2e-08 35.2 0.0 1.2 1 0 0 1 1 1 1 Response regulator receiver domain DNA_pol3_chi PF04364.13 CCF44531.1 - 0.16 12.2 0.0 0.26 11.5 0.0 1.3 1 0 0 1 1 1 0 DNA polymerase III chi subunit, HolC AA_permease_2 PF13520.6 CCF44532.1 - 2.6e-56 191.3 49.4 3.3e-56 190.9 49.4 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CCF44532.1 - 2.5e-23 82.4 44.3 3.5e-23 81.9 44.3 1.1 1 0 0 1 1 1 1 Amino acid permease Cation_efflux PF01545.21 CCF44534.1 - 6.7e-08 32.5 12.3 4e-07 30.0 2.8 2.1 1 1 1 2 2 2 2 Cation efflux family ZT_dimer PF16916.5 CCF44534.1 - 5.4e-07 29.7 0.1 1.2e-06 28.6 0.1 1.5 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter DUF3622 PF12286.8 CCF44535.1 - 2.2 8.7 5.8 8.1 6.9 0.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3622) Glyco_hydro_18 PF00704.28 CCF44537.1 - 5e-22 79.0 0.0 7e-22 78.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 SUR7 PF06687.12 CCF44538.1 - 7.3e-27 94.4 8.8 9.5e-27 94.0 8.8 1.1 1 0 0 1 1 1 1 SUR7/PalI family HsbA PF12296.8 CCF44539.1 - 9.9e-18 64.7 5.2 1.6e-17 64.0 5.2 1.3 1 0 0 1 1 1 1 Hydrophobic surface binding protein A BAR_3 PF16746.5 CCF44539.1 - 0.11 12.2 2.0 0.18 11.5 2.0 1.5 1 1 0 1 1 1 0 BAR domain of APPL family Syntaxin-6_N PF09177.11 CCF44539.1 - 0.13 12.9 1.3 0.44 11.1 0.3 2.0 2 0 0 2 2 2 0 Syntaxin 6, N-terminal adh_short_C2 PF13561.6 CCF44542.1 - 1.2e-51 175.5 0.1 1.5e-51 175.2 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF44542.1 - 7.2e-44 149.6 0.1 9.2e-44 149.2 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF44542.1 - 2.6e-16 60.0 0.1 4e-16 59.4 0.1 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF44542.1 - 0.00081 18.9 0.1 0.0012 18.3 0.1 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CCF44542.1 - 0.026 13.9 0.0 0.039 13.4 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase HATPase_c PF02518.26 CCF44542.1 - 0.1 13.1 0.0 0.4 11.2 0.0 1.9 2 0 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Dabb PF07876.12 CCF44545.1 - 2.3e-10 41.0 0.0 2.8e-10 40.7 0.0 1.1 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain BLACT_WH PF17778.1 CCF44546.1 - 3.7e-17 62.0 0.1 6.5e-17 61.3 0.1 1.4 1 0 0 1 1 1 1 Beta-lactamase associated winged helix domain Lactamase_B PF00753.27 CCF44546.1 - 2.1e-13 50.7 0.6 1.5e-10 41.4 0.6 2.2 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CCF44546.1 - 2e-05 24.2 0.1 6.3e-05 22.6 0.0 1.9 2 1 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 CCF44546.1 - 0.0023 17.9 0.0 0.0036 17.2 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain UCH PF00443.29 CCF44547.1 - 4.9e-49 167.1 0.4 7.7e-49 166.5 0.4 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CCF44547.1 - 2.9e-29 102.7 2.7 2.9e-29 102.7 2.7 1.8 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 CCF44547.1 - 2.2e-05 24.7 0.4 2.2e-05 24.7 0.4 2.3 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein DZR PF12773.7 CCF44547.1 - 0.88 9.7 10.7 1.3 9.2 1.9 3.6 4 1 0 4 4 4 0 Double zinc ribbon zf-CCHC PF00098.23 CCF44547.1 - 5.7 7.2 10.7 29 5.0 0.1 4.4 4 0 0 4 4 4 0 Zinc knuckle N6-adenineMlase PF10237.9 CCF44548.1 - 1.4e-47 161.4 0.0 1.8e-47 161.1 0.0 1.1 1 0 0 1 1 1 1 Probable N6-adenine methyltransferase NmrA PF05368.13 CCF44549.1 - 2.6e-16 59.9 0.0 3.5e-16 59.5 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 CCF44549.1 - 6.2e-15 55.3 0.1 1.2e-14 54.3 0.1 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CCF44549.1 - 9.5e-15 55.0 0.0 1.6e-14 54.2 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 CCF44549.1 - 5.6e-11 42.0 0.1 2e-10 40.1 0.1 1.8 1 1 1 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 CCF44549.1 - 1.2e-08 34.8 0.1 2e-08 34.1 0.1 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 CCF44549.1 - 2.6e-08 33.3 0.0 1.2e-06 27.9 0.0 2.5 1 1 0 1 1 1 1 RmlD substrate binding domain adh_short PF00106.25 CCF44549.1 - 8.2e-05 22.1 0.0 0.00013 21.5 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF44549.1 - 0.0052 16.7 0.0 2.3 8.1 0.0 2.2 2 0 0 2 2 2 2 KR domain adh_short_C2 PF13561.6 CCF44549.1 - 0.0088 15.6 0.0 0.014 15.0 0.0 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Polysacc_synt_2 PF02719.15 CCF44549.1 - 0.0096 15.1 0.0 0.015 14.5 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 CCF44549.1 - 0.026 13.7 0.4 2.7 7.1 0.4 2.8 1 1 1 2 2 2 0 Male sterility protein NAD_synthase PF02540.17 CCF44549.1 - 0.062 12.4 0.0 0.1 11.7 0.0 1.3 1 0 0 1 1 1 0 NAD synthase 2-Hacid_dh_C PF02826.19 CCF44549.1 - 0.16 11.3 0.2 1.2 8.4 0.2 2.1 1 1 1 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ApbA PF02558.16 CCF44549.1 - 0.18 11.5 0.0 0.39 10.3 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA PCI PF01399.27 CCF44550.1 - 8.9e-11 42.2 0.0 1.7e-10 41.3 0.0 1.5 1 0 0 1 1 1 1 PCI domain Rpn9_C PF18261.1 CCF44550.1 - 1.1e-07 31.3 2.6 2.3e-07 30.2 2.6 1.5 1 0 0 1 1 1 1 Rpn9 C-terminal helix Dam PF05869.11 CCF44550.1 - 0.041 13.5 0.0 0.16 11.5 0.0 2.0 2 0 0 2 2 2 0 DNA N-6-adenine-methyltransferase (Dam) Dimerisation2 PF16864.5 CCF44550.1 - 0.09 12.8 0.0 0.2 11.7 0.0 1.6 1 0 0 1 1 1 0 Dimerisation domain HTH_47 PF16221.5 CCF44550.1 - 0.17 11.5 0.2 10 5.8 0.0 2.4 2 0 0 2 2 2 0 winged helix-turn-helix Gaa1 PF04114.14 CCF44551.1 - 4.7e-20 72.1 17.8 3.2e-16 59.4 6.5 2.0 1 1 1 2 2 2 2 Gaa1-like, GPI transamidase component DUF4305 PF14146.6 CCF44551.1 - 2.7 8.3 5.8 1.8 8.9 1.4 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4305) FAD_binding_4 PF01565.23 CCF44552.1 - 5e-14 52.2 1.7 1.2e-13 51.0 1.7 1.7 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 CCF44552.1 - 3.9e-10 39.7 0.0 7.2e-10 38.8 0.0 1.5 1 0 0 1 1 1 1 Berberine and berberine like DUF4043 PF13252.6 CCF44553.1 - 6 5.9 11.8 0.2 10.7 5.7 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4043) DUF572 PF04502.13 CCF44557.1 - 0.0016 18.1 1.3 0.0026 17.5 1.3 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF572) DUF2461 PF09365.10 CCF44557.1 - 0.011 15.7 5.2 0.024 14.6 0.0 2.2 2 0 0 2 2 2 0 Conserved hypothetical protein (DUF2461) D5_N PF08706.11 CCF44557.1 - 0.26 11.5 1.7 0.71 10.1 1.7 1.7 2 0 0 2 2 2 0 D5 N terminal like Porph_ging PF09697.10 CCF44557.1 - 2.7 8.6 4.9 6.1 7.5 1.9 2.6 2 0 0 2 2 2 0 Protein of unknown function (Porph_ging) DUF1533 PF07550.11 CCF44559.1 - 0.012 15.5 0.1 0.027 14.3 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1533) Invasin_D3 PF09134.10 CCF44559.1 - 0.075 13.3 0.4 0.55 10.6 0.1 2.1 2 0 0 2 2 2 0 Invasin, domain 3 MFS_1 PF07690.16 CCF44560.1 - 0.039 12.9 11.7 0.26 10.2 11.7 2.0 1 1 0 1 1 1 0 Major Facilitator Superfamily Tmemb_170 PF10190.9 CCF44560.1 - 0.12 12.8 4.5 0.35 11.3 4.6 1.8 1 1 0 1 1 1 0 Putative transmembrane protein 170 Thiolase_N PF00108.23 CCF44562.1 - 1.2e-68 231.3 1.1 1.6e-68 230.9 1.1 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 CCF44562.1 - 4.6e-39 132.9 0.7 4.6e-39 132.9 0.7 1.9 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 CCF44562.1 - 0.023 14.3 0.2 0.094 12.3 0.1 2.1 2 0 0 2 2 2 0 Beta-ketoacyl synthase, N-terminal domain Ank_2 PF12796.7 CCF44564.1 - 7e-28 97.1 1.5 1.1e-09 38.7 0.0 4.1 2 1 3 5 5 5 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CCF44564.1 - 1.9e-25 88.6 3.0 1.8e-10 40.8 0.0 5.5 4 2 2 6 6 6 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 CCF44564.1 - 5.1e-24 84.3 1.8 7.4e-08 32.8 0.0 5.5 4 1 2 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.30 CCF44564.1 - 2.6e-20 71.9 7.7 0.00023 21.5 0.0 7.1 7 0 0 7 7 7 4 Ankyrin repeat Ank_3 PF13606.6 CCF44564.1 - 3.3e-19 67.0 0.7 7.8e-06 25.9 0.0 6.8 8 0 0 8 8 8 3 Ankyrin repeat MOFRL PF05161.13 CCF44564.1 - 0.099 12.8 0.4 3.4 7.9 0.2 2.8 3 0 0 3 3 3 0 MOFRL family NUDIX PF00293.28 CCF44565.1 - 6.7e-05 22.9 0.0 0.00013 22.1 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain Med19 PF10278.9 CCF44566.1 - 0.073 13.0 5.3 0.12 12.4 5.3 1.2 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 Dehydrin PF00257.19 CCF44566.1 - 0.21 12.1 20.6 1.9 9.0 20.6 2.2 1 1 0 1 1 1 0 Dehydrin DUF755 PF05501.11 CCF44566.1 - 4.9 7.4 16.2 9.1 6.6 16.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF755) Pkinase PF00069.25 CCF44568.1 - 1.1e-17 64.2 0.0 1.6e-17 63.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF44568.1 - 2e-09 37.1 0.0 3.2e-09 36.4 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF44568.1 - 0.00034 20.0 0.0 0.00046 19.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 CCF44568.1 - 0.00054 20.0 0.2 0.0007 19.6 0.2 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 CCF44568.1 - 0.014 14.7 0.0 0.02 14.2 0.0 1.1 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family VWA_2 PF13519.6 CCF44569.1 - 0.14 12.8 0.0 0.34 11.6 0.0 1.8 1 1 0 1 1 1 0 von Willebrand factor type A domain FAD_binding_3 PF01494.19 CCF44570.1 - 1.5e-21 77.1 0.0 3.4e-21 75.9 0.0 1.6 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CCF44570.1 - 4.7e-09 35.9 1.0 1.5e-05 24.4 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCF44570.1 - 5.4e-09 36.1 1.2 1.2e-06 28.4 1.2 2.1 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CCF44570.1 - 4.8e-08 33.1 0.5 9.8e-08 32.1 0.5 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 CCF44570.1 - 2.9e-06 26.6 3.2 2.9e-06 26.6 3.2 2.1 3 0 0 3 3 3 1 FAD binding domain Trp_halogenase PF04820.14 CCF44570.1 - 4.4e-06 25.8 0.6 0.0029 16.5 0.4 2.2 2 0 0 2 2 2 2 Tryptophan halogenase Amino_oxidase PF01593.24 CCF44570.1 - 3.6e-05 23.3 1.4 0.03 13.6 0.2 2.3 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase Pyr_redox PF00070.27 CCF44570.1 - 0.00014 22.3 0.4 0.003 18.1 0.2 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCF44570.1 - 0.00021 20.7 0.3 0.0022 17.3 0.3 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CCF44570.1 - 0.00055 18.7 1.0 0.0025 16.6 0.3 1.9 2 0 0 2 2 2 1 HI0933-like protein FAD_oxidored PF12831.7 CCF44570.1 - 0.00058 19.3 1.4 0.00097 18.6 1.4 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 CCF44570.1 - 0.0065 15.8 0.1 0.013 14.8 0.1 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Lycopene_cycl PF05834.12 CCF44570.1 - 0.01 14.9 0.4 3.3 6.6 0.0 2.1 2 0 0 2 2 2 0 Lycopene cyclase protein GIDA PF01134.22 CCF44570.1 - 0.019 14.1 1.1 0.019 14.1 1.1 1.7 2 0 0 2 2 2 0 Glucose inhibited division protein A ApbA PF02558.16 CCF44570.1 - 0.021 14.5 0.2 0.045 13.4 0.2 1.6 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Thi4 PF01946.17 CCF44570.1 - 0.033 13.4 0.1 0.068 12.4 0.1 1.5 1 0 0 1 1 1 0 Thi4 family MCRA PF06100.11 CCF44570.1 - 0.086 11.6 0.0 0.12 11.1 0.0 1.2 1 0 0 1 1 1 0 MCRA family DUF1344 PF07076.11 CCF44570.1 - 0.12 12.3 0.1 0.27 11.2 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1344) K_oxygenase PF13434.6 CCF44571.1 - 6.5e-14 51.8 0.0 1.2e-11 44.4 0.0 2.7 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) FMO-like PF00743.19 CCF44571.1 - 7.5e-11 41.1 0.0 1.1e-10 40.6 0.0 1.1 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 CCF44571.1 - 2.6e-09 36.8 0.0 2.7e-08 33.4 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCF44571.1 - 3.6e-07 29.7 0.0 7.7e-07 28.7 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCF44571.1 - 4.2e-05 23.7 0.0 0.00014 22.0 0.0 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 CCF44571.1 - 0.00061 19.8 0.0 0.37 10.8 0.0 3.2 2 1 0 2 2 2 1 FAD-NAD(P)-binding Thi4 PF01946.17 CCF44571.1 - 0.0056 15.9 0.1 0.026 13.8 0.0 2.1 3 0 0 3 3 3 1 Thi4 family DAO PF01266.24 CCF44571.1 - 0.012 15.2 0.0 3.4 7.2 0.0 2.9 3 0 0 3 3 3 0 FAD dependent oxidoreductase Mqo PF06039.15 CCF44571.1 - 0.12 10.9 0.0 11 4.4 0.0 2.1 2 0 0 2 2 2 0 Malate:quinone oxidoreductase (Mqo) Anth_synt_I_N PF04715.13 CCF44572.1 - 6.9e-07 29.6 0.0 9.6e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 Anthranilate synthase component I, N terminal region Ribosomal_L3 PF00297.22 CCF44574.1 - 2.4e-06 26.8 0.0 2.8e-06 26.6 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L3 Glyco_hydro_18 PF00704.28 CCF44575.1 - 2.2e-43 149.2 0.0 2.7e-43 148.9 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Chitin_bind_1 PF00187.19 CCF44575.1 - 1.4e-11 44.7 41.1 2e-10 41.0 16.0 2.6 2 0 0 2 2 2 2 Chitin recognition protein HET PF06985.11 CCF44576.1 - 6.4e-31 107.7 0.0 2.2e-30 106.0 0.0 1.9 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) adh_short_C2 PF13561.6 CCF44580.1 - 5e-60 203.0 2.4 5.7e-60 202.8 2.4 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF44580.1 - 1.4e-38 132.4 1.4 1.7e-38 132.1 1.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF44580.1 - 2.6e-14 53.5 0.4 3.8e-14 53.0 0.4 1.2 1 0 0 1 1 1 1 KR domain YjeF_N PF03853.15 CCF44580.1 - 0.061 13.2 0.1 0.15 11.9 0.1 1.6 2 0 0 2 2 2 0 YjeF-related protein N-terminus SRF-TF PF00319.18 CCF44580.1 - 0.069 12.7 0.0 0.15 11.6 0.0 1.5 1 0 0 1 1 1 0 SRF-type transcription factor (DNA-binding and dimerisation domain) Spc7 PF08317.11 CCF44581.1 - 1.5e-06 27.3 61.2 0.026 13.4 25.0 4.0 1 1 1 2 2 2 2 Spc7 kinetochore protein Filament PF00038.21 CCF44581.1 - 3.7e-05 23.5 50.4 0.00015 21.5 34.1 2.3 1 1 0 2 2 2 2 Intermediate filament protein Apolipoprotein PF01442.18 CCF44581.1 - 0.00011 22.1 66.6 0.083 12.8 27.0 3.3 1 1 2 3 3 3 3 Apolipoprotein A1/A4/E domain Tup_N PF08581.10 CCF44581.1 - 0.00025 21.3 33.9 0.09 13.1 1.8 5.9 3 2 2 5 5 5 1 Tup N-terminal Leu_zip PF15294.6 CCF44581.1 - 0.00028 20.5 53.0 0.037 13.5 17.8 3.4 1 1 2 3 3 3 3 Leucine zipper HMMR_N PF15905.5 CCF44581.1 - 0.00033 20.2 57.4 0.056 12.9 40.0 3.4 1 1 2 3 3 3 3 Hyaluronan mediated motility receptor N-terminal TPR_MLP1_2 PF07926.12 CCF44581.1 - 0.00066 19.8 72.3 0.11 12.6 20.4 4.9 1 1 4 5 5 5 2 TPR/MLP1/MLP2-like protein GAS PF13851.6 CCF44581.1 - 0.0011 18.3 59.2 0.035 13.5 23.5 4.2 1 1 2 3 3 3 2 Growth-arrest specific micro-tubule binding Lebercilin PF15619.6 CCF44581.1 - 0.0016 18.1 63.3 0.11 12.1 24.0 3.8 1 1 1 3 3 3 3 Ciliary protein causing Leber congenital amaurosis disease BRE1 PF08647.11 CCF44581.1 - 0.0018 18.3 62.0 0.094 12.8 0.7 5.7 2 1 4 6 6 6 2 BRE1 E3 ubiquitin ligase Golgin_A5 PF09787.9 CCF44581.1 - 0.0023 17.4 51.5 0.41 10.1 15.0 3.3 1 1 2 3 3 3 3 Golgin subfamily A member 5 DUF4407 PF14362.6 CCF44581.1 - 0.0025 17.2 64.7 0.019 14.3 24.8 3.5 1 1 1 2 2 1 1 Domain of unknown function (DUF4407) Rab5-bind PF09311.11 CCF44581.1 - 0.0029 17.1 53.4 0.24 10.7 34.9 4.1 1 1 1 2 2 2 1 Rabaptin-like protein CALCOCO1 PF07888.11 CCF44581.1 - 0.0029 16.6 32.3 0.0029 16.6 32.3 2.6 1 1 1 2 2 2 1 Calcium binding and coiled-coil domain (CALCOCO1) like DUF1664 PF07889.12 CCF44581.1 - 0.0033 17.4 36.0 0.013 15.5 2.2 5.0 2 2 3 5 5 5 2 Protein of unknown function (DUF1664) Rootletin PF15035.6 CCF44581.1 - 0.0042 17.1 22.7 0.0042 17.1 22.7 3.5 1 1 2 3 3 3 1 Ciliary rootlet component, centrosome cohesion SlyX PF04102.12 CCF44581.1 - 0.0046 17.6 6.5 0.0046 17.6 6.5 6.8 1 1 5 6 6 6 1 SlyX ATG16 PF08614.11 CCF44581.1 - 0.0062 16.8 74.0 0.095 12.9 7.9 3.3 1 1 1 3 3 3 1 Autophagy protein 16 (ATG16) DUF4201 PF13870.6 CCF44581.1 - 0.018 14.8 50.4 0.58 9.9 4.6 5.7 1 1 3 5 5 5 0 Domain of unknown function (DUF4201) CC2-LZ PF16516.5 CCF44581.1 - 0.021 15.2 1.7 0.021 15.2 1.7 6.7 1 1 5 7 7 6 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator MscS_porin PF12795.7 CCF44581.1 - 0.021 14.4 74.2 0.23 11.0 12.0 4.2 1 1 4 5 5 5 0 Mechanosensitive ion channel porin domain Occludin_ELL PF07303.13 CCF44581.1 - 0.027 15.2 29.3 0.13 13.0 0.7 5.5 1 1 5 6 6 6 0 Occludin homology domain SHE3 PF17078.5 CCF44581.1 - 0.039 13.6 41.1 0.061 13.0 10.6 3.1 1 1 1 3 3 3 0 SWI5-dependent HO expression protein 3 Baculo_PEP_C PF04513.12 CCF44581.1 - 0.044 13.8 38.0 0.92 9.5 10.2 4.0 1 1 3 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Phage_GP20 PF06810.11 CCF44581.1 - 0.053 13.3 67.9 0.89 9.4 9.2 5.4 1 1 3 4 4 4 0 Phage minor structural protein GP20 ALIX_LYPXL_bnd PF13949.6 CCF44581.1 - 0.074 12.3 49.5 0.48 9.7 9.0 2.8 1 1 2 3 3 3 0 ALIX V-shaped domain binding to HIV Prefoldin_2 PF01920.20 CCF44581.1 - 0.088 12.8 58.2 0.1 12.6 6.2 6.9 3 2 2 5 5 4 0 Prefoldin subunit Fez1 PF06818.15 CCF44581.1 - 0.1 13.1 53.1 0.54 10.7 17.4 3.1 1 1 1 2 2 2 0 Fez1 HOOK PF05622.12 CCF44581.1 - 0.1 10.7 57.3 0.078 11.1 7.9 3.2 1 1 1 3 3 3 0 HOOK protein EzrA PF06160.12 CCF44581.1 - 0.15 10.2 44.3 1 7.4 7.0 3.2 1 1 0 1 1 1 0 Septation ring formation regulator, EzrA FlaC_arch PF05377.11 CCF44581.1 - 0.23 11.9 26.2 6.5 7.2 3.3 7.9 2 2 5 7 7 7 0 Flagella accessory protein C (FlaC) YmdB PF13277.6 CCF44581.1 - 0.27 10.5 3.3 0.13 11.5 0.4 2.1 2 0 0 2 2 2 0 YmdB-like protein ABC_tran_CTD PF16326.5 CCF44581.1 - 0.3 11.4 69.6 0.68 10.2 4.9 7.6 1 1 6 7 7 7 0 ABC transporter C-terminal domain TACC_C PF05010.14 CCF44581.1 - 0.31 10.8 46.6 0.041 13.7 17.0 3.4 1 1 1 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal STAT_alpha PF01017.20 CCF44581.1 - 0.31 10.9 35.1 0.15 11.9 7.8 3.8 1 1 3 4 4 4 0 STAT protein, all-alpha domain Fib_alpha PF08702.10 CCF44581.1 - 0.38 10.9 34.2 1.7 8.8 4.1 4.6 1 1 2 4 4 4 0 Fibrinogen alpha/beta chain family IFT57 PF10498.9 CCF44581.1 - 0.42 9.5 42.6 2.3 7.1 6.0 4.1 1 1 3 4 4 4 0 Intra-flagellar transport protein 57 CENP-H PF05837.12 CCF44581.1 - 0.42 11.0 58.3 0.56 10.6 10.9 4.1 2 1 2 4 4 4 0 Centromere protein H (CENP-H) DUF3584 PF12128.8 CCF44581.1 - 0.49 7.8 63.8 1.4 6.3 47.7 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) APG6_N PF17675.1 CCF44581.1 - 0.58 10.7 74.7 7.2 7.2 14.7 4.8 1 1 3 4 4 3 0 Apg6 coiled-coil region DUF2353 PF09789.9 CCF44581.1 - 0.65 9.3 47.8 0.69 9.2 23.9 2.5 2 1 0 2 2 2 0 Uncharacterized coiled-coil protein (DUF2353) DUF724 PF05266.14 CCF44581.1 - 0.73 9.6 48.0 0.19 11.5 6.5 4.3 1 1 3 4 4 3 0 Protein of unknown function (DUF724) MAD PF05557.13 CCF44581.1 - 0.77 8.1 55.1 0.089 11.1 36.5 1.9 1 1 1 2 2 2 0 Mitotic checkpoint protein FliJ PF02050.16 CCF44581.1 - 0.8 9.9 52.0 0.091 13.0 3.8 5.6 1 1 5 6 6 6 0 Flagellar FliJ protein CENP-F_leu_zip PF10473.9 CCF44581.1 - 0.83 9.7 55.6 0.13 12.3 12.0 4.4 1 1 2 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CEP63 PF17045.5 CCF44581.1 - 0.87 9.4 47.6 12 5.7 10.4 3.6 1 1 1 2 2 2 0 Centrosomal protein of 63 kDa Cast PF10174.9 CCF44581.1 - 0.92 7.7 54.5 10 4.2 32.6 3.1 1 1 1 2 2 2 0 RIM-binding protein of the cytomatrix active zone MAP65_ASE1 PF03999.12 CCF44581.1 - 1.6 7.3 31.8 0.61 8.7 12.4 2.9 1 1 1 2 2 2 0 Microtubule associated protein (MAP65/ASE1 family) Atg14 PF10186.9 CCF44581.1 - 1.9 7.5 52.7 1.4 7.9 20.0 3.4 1 1 2 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 FAM76 PF16046.5 CCF44581.1 - 1.9 7.7 48.4 1.5 8.1 7.2 3.5 1 1 3 4 4 4 0 FAM76 protein DHR10 PF18595.1 CCF44581.1 - 2 8.5 69.8 0.52 10.4 11.6 5.2 2 2 0 4 4 4 0 Designed helical repeat protein 10 domain DUF4686 PF15742.5 CCF44581.1 - 2.1 7.4 57.7 0.075 12.2 33.2 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4686) UPF0242 PF06785.11 CCF44581.1 - 3.1 7.9 58.3 2.3 8.3 8.6 4.0 1 1 3 4 4 4 0 Uncharacterised protein family (UPF0242) N-terminus CCDC144C PF14915.6 CCF44581.1 - 3.2 6.8 56.3 4.6 6.3 22.7 3.8 1 1 2 3 3 3 0 CCDC144C protein coiled-coil region SYCE1 PF15233.6 CCF44581.1 - 3.3 7.8 48.2 0.88 9.6 15.3 3.3 1 1 2 3 3 3 0 Synaptonemal complex central element protein 1 Laminin_I PF06008.14 CCF44581.1 - 3.9 7.1 65.8 10 5.7 34.3 3.2 1 1 1 2 2 2 0 Laminin Domain I PspA_IM30 PF04012.12 CCF44581.1 - 3.9 7.0 66.5 0.66 9.5 10.8 4.5 1 1 2 4 4 4 0 PspA/IM30 family DUF812 PF05667.11 CCF44581.1 - 4.1 6.2 54.6 1.5 7.7 35.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF812) Tmemb_cc2 PF10267.9 CCF44581.1 - 4.6 6.3 45.4 5.7e+03 -3.9 45.8 3.9 1 1 0 1 1 0 0 Predicted transmembrane and coiled-coil 2 protein YabA PF06156.13 CCF44581.1 - 4.8 7.9 42.1 0.8 10.4 5.8 5.1 1 1 3 4 4 3 0 Initiation control protein YabA DUF4618 PF15397.6 CCF44581.1 - 6.5 6.1 43.7 13 5.1 12.4 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4618) Pox_A_type_inc PF04508.12 CCF44581.1 - 6.7 6.7 8.8 15 5.6 0.2 4.8 4 0 0 4 4 4 0 Viral A-type inclusion protein repeat Prefoldin PF02996.17 CCF44581.1 - 8.3 6.3 52.7 0.096 12.6 4.3 7.2 2 2 5 7 7 6 0 Prefoldin subunit CREPT PF16566.5 CCF44581.1 - 8.7 6.5 45.5 0.73 10.0 2.1 5.1 1 1 4 5 5 5 0 Cell-cycle alteration and expression-elevated protein in tumour Glyco_hydro_43 PF04616.14 CCF44582.1 - 5.3e-23 81.7 0.1 6.3e-23 81.5 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 Proteasome_A_N PF10584.9 CCF44582.1 - 0.042 13.5 0.1 0.12 12.1 0.1 1.7 2 0 0 2 2 2 0 Proteasome subunit A N-terminal signature DUF4387 PF14330.6 CCF44583.1 - 4.4e-34 117.1 0.0 7.5e-34 116.3 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4387) AtuA PF07287.11 CCF44583.1 - 0.0032 16.2 0.0 0.0047 15.7 0.0 1.2 1 0 0 1 1 1 1 Acyclic terpene utilisation family protein AtuA HMG_box PF00505.19 CCF44585.1 - 2.3e-25 88.8 1.7 3.4e-25 88.2 1.7 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 CCF44585.1 - 3.1e-18 66.1 2.2 4.6e-18 65.6 2.2 1.3 1 0 0 1 1 1 1 HMG-box domain Ccdc124 PF06244.12 CCF44585.1 - 0.001 19.6 2.1 0.0014 19.2 0.0 1.9 1 1 1 2 2 2 1 Coiled-coil domain-containing protein 124 /Oxs1 HMG_box_5 PF14887.6 CCF44585.1 - 0.014 15.3 0.5 0.034 14.1 0.5 1.6 1 0 0 1 1 1 0 HMG (high mobility group) box 5 CHDNT PF08073.12 CCF44585.1 - 0.051 13.5 0.0 0.083 12.9 0.0 1.3 1 0 0 1 1 1 0 CHDNT (NUC034) domain Prefoldin_2 PF01920.20 CCF44586.1 - 9.7e-09 35.1 1.4 1e-08 35.1 1.4 1.0 1 0 0 1 1 1 1 Prefoldin subunit bZIP_1 PF00170.21 CCF44586.1 - 0.0035 17.4 2.5 0.0043 17.1 2.5 1.1 1 0 0 1 1 1 1 bZIP transcription factor Prefoldin PF02996.17 CCF44586.1 - 0.0093 15.9 0.7 0.0093 15.9 0.7 1.0 1 0 0 1 1 1 1 Prefoldin subunit Baculo_PEP_C PF04513.12 CCF44586.1 - 0.013 15.5 0.1 0.013 15.5 0.1 1.0 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus PI3K_P85_iSH2 PF16454.5 CCF44586.1 - 0.021 14.5 0.9 0.022 14.4 0.9 1.0 1 0 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain FlaC_arch PF05377.11 CCF44586.1 - 0.04 14.3 2.9 0.075 13.4 2.9 1.5 1 1 0 1 1 1 0 Flagella accessory protein C (FlaC) TssO PF17561.2 CCF44586.1 - 0.041 14.0 0.3 0.043 13.9 0.3 1.0 1 0 0 1 1 1 0 Type VI secretion system, TssO DUF1664 PF07889.12 CCF44586.1 - 0.041 13.9 0.2 0.044 13.8 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) MtrG PF04210.13 CCF44586.1 - 0.054 13.3 0.2 0.073 12.9 0.2 1.3 1 1 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit G HU-CCDC81_bac_2 PF18175.1 CCF44586.1 - 0.1 12.5 0.6 0.49 10.3 0.5 1.9 1 1 1 2 2 2 0 CCDC81-like prokaryotic HU domain 2 MFS_1 PF07690.16 CCF44587.1 - 2.4e-16 59.6 12.0 2.9e-16 59.3 12.0 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF44587.1 - 6.3e-07 28.6 2.4 8.9e-07 28.1 2.4 1.3 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_2 PF13347.6 CCF44587.1 - 8.4e-07 27.9 2.3 1.1e-06 27.6 2.3 1.1 1 0 0 1 1 1 1 MFS/sugar transport protein MFS_4 PF06779.14 CCF44587.1 - 8.6e-06 25.3 1.0 1e-05 25.0 1.0 1.1 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB X PF00739.19 CCF44588.1 - 0.085 13.0 0.1 0.17 12.0 0.1 1.4 1 0 0 1 1 1 0 Trans-activation protein X CLASP_N PF12348.8 CCF44588.1 - 0.15 11.6 0.1 1.5 8.3 0.0 2.5 3 0 0 3 3 3 0 CLASP N terminal MFS_1 PF07690.16 CCF44590.1 - 7.3e-22 77.8 31.1 2.7e-18 66.0 7.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3328 PF11807.8 CCF44592.1 - 9.5e-09 35.4 1.4 2.4e-08 34.0 1.4 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF3328) Methyltransf_31 PF13847.6 CCF44593.1 - 6.1e-16 58.6 0.0 1e-15 57.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF44593.1 - 6.7e-12 46.0 0.1 3.1e-11 43.8 0.1 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF44593.1 - 4.4e-10 40.1 0.1 1.3e-08 35.3 0.1 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 CCF44593.1 - 2.1e-09 37.1 0.0 2.3e-08 33.7 0.0 2.4 2 1 1 3 3 3 1 Putative methyltransferase Methyltransf_12 PF08242.12 CCF44593.1 - 2.1e-08 34.8 0.0 3.3e-08 34.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF44593.1 - 2.2e-07 30.8 0.0 3e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCF44593.1 - 2.9e-06 26.8 0.0 2.1e-05 24.0 0.0 2.1 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 CCF44593.1 - 2.6e-05 23.9 0.0 4.2e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_2 PF00891.18 CCF44593.1 - 0.00035 19.9 0.0 0.00079 18.8 0.0 1.5 2 0 0 2 2 2 1 O-methyltransferase domain Methyltransf_18 PF12847.7 CCF44593.1 - 0.00063 19.7 0.0 0.0012 18.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 CCF44593.1 - 0.0084 15.9 0.0 0.016 14.9 0.0 1.5 1 1 1 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_32 PF13679.6 CCF44593.1 - 0.024 14.6 0.0 0.036 14.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain CMAS PF02353.20 CCF44593.1 - 0.14 11.5 0.0 0.24 10.7 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Condensation PF00668.20 CCF44594.1 - 2.9e-20 72.4 0.0 4.2e-19 68.6 0.0 2.3 1 1 0 1 1 1 1 Condensation domain DUF2087 PF09860.9 CCF44594.1 - 0.069 13.3 0.1 3.4 7.9 0.2 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2087) ArfGap PF01412.18 CCF44595.1 - 3.6e-40 136.7 0.7 6.2e-40 135.9 0.7 1.4 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf partial_CstF PF15861.5 CCF44595.1 - 0.078 12.8 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 Partial cleavage stimulation factor domain 2-Hacid_dh_C PF02826.19 CCF44596.1 - 4.1e-52 176.1 0.1 7.6e-52 175.2 0.1 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CCF44596.1 - 3.9e-36 123.7 1.2 1e-35 122.3 0.6 1.8 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain ACT PF01842.25 CCF44596.1 - 9e-05 22.2 0.2 0.00055 19.6 0.0 2.4 2 0 0 2 2 2 1 ACT domain XdhC_C PF13478.6 CCF44596.1 - 0.023 15.2 0.0 0.057 13.9 0.0 1.7 1 0 0 1 1 1 0 XdhC Rossmann domain DUF21 PF01595.20 CCF44597.1 - 1e-33 116.5 0.0 1.7e-33 115.8 0.0 1.3 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 CCF44597.1 - 0.0006 20.2 0.1 0.035 14.5 0.0 3.1 2 0 0 2 2 2 1 CBS domain Lactonase PF10282.9 CCF44598.1 - 5.9e-19 68.5 0.0 7.6e-19 68.2 0.0 1.2 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller ABC_tran PF00005.27 CCF44599.1 - 9.5e-45 152.5 0.0 4.7e-25 88.7 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 CCF44599.1 - 2e-34 119.5 16.0 6.9e-22 78.4 5.2 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 CCF44599.1 - 4.6e-08 32.8 0.5 0.011 15.2 0.0 4.0 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CCF44599.1 - 2.2e-06 27.3 0.6 0.0054 16.5 0.1 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.6 CCF44599.1 - 1.4e-05 25.1 3.1 0.062 13.1 0.1 4.1 3 1 1 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 CCF44599.1 - 2.1e-05 24.5 0.1 0.12 12.2 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 CCF44599.1 - 0.00022 21.6 0.0 0.01 16.3 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain AAA_7 PF12775.7 CCF44599.1 - 0.00037 20.1 0.1 0.22 11.0 0.0 2.3 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA PF00004.29 CCF44599.1 - 0.00051 20.5 1.0 0.069 13.6 0.1 3.1 3 1 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CCF44599.1 - 0.00069 19.9 3.8 0.065 13.5 0.2 3.2 2 1 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 CCF44599.1 - 0.00072 19.6 0.2 0.38 10.9 0.1 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_23 PF13476.6 CCF44599.1 - 0.0018 18.8 1.7 0.44 11.0 0.1 2.5 2 1 0 2 2 2 1 AAA domain NB-ARC PF00931.22 CCF44599.1 - 0.0021 17.3 0.3 0.017 14.3 0.0 2.4 3 0 0 3 3 3 1 NB-ARC domain DUF87 PF01935.17 CCF44599.1 - 0.003 17.7 1.5 0.53 10.4 0.1 2.3 2 0 0 2 2 2 1 Helicase HerA, central domain RNA_helicase PF00910.22 CCF44599.1 - 0.011 16.2 0.0 1.6 9.1 0.0 3.1 3 0 0 3 3 3 0 RNA helicase AAA_25 PF13481.6 CCF44599.1 - 0.014 15.0 0.2 1.3 8.6 0.0 2.6 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.13 CCF44599.1 - 0.027 13.6 0.3 5.9 6.0 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) FtsK_SpoIIIE PF01580.18 CCF44599.1 - 0.055 12.8 0.5 3 7.1 0.0 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_5 PF07728.14 CCF44599.1 - 0.068 13.2 2.2 10 6.1 0.1 3.8 3 1 0 3 3 3 0 AAA domain (dynein-related subfamily) Rad17 PF03215.15 CCF44599.1 - 0.088 12.7 2.3 0.31 10.9 0.0 2.6 3 0 0 3 3 3 0 Rad17 P-loop domain T2SSE PF00437.20 CCF44599.1 - 0.093 11.8 0.4 0.64 9.0 0.0 2.1 2 0 0 2 2 2 0 Type II/IV secretion system protein ATPase_2 PF01637.18 CCF44599.1 - 0.13 12.1 0.1 0.62 9.9 0.0 2.1 3 0 0 3 3 2 0 ATPase domain predominantly from Archaea Piezo_RRas_bdg PF12166.8 CCF44599.1 - 0.15 11.3 0.1 0.23 10.7 0.1 1.2 1 0 0 1 1 1 0 Piezo non-specific cation channel, R-Ras-binding domain IstB_IS21 PF01695.17 CCF44599.1 - 0.15 11.8 2.0 32 4.2 0.0 3.4 4 0 0 4 4 3 0 IstB-like ATP binding protein Dynamin_N PF00350.23 CCF44599.1 - 0.16 12.0 1.8 0.83 9.7 0.3 2.2 2 0 0 2 2 2 0 Dynamin family PduV-EutP PF10662.9 CCF44599.1 - 0.16 11.7 1.2 0.33 10.7 0.0 2.0 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_15 PF13175.6 CCF44599.1 - 0.17 11.6 0.0 6.6 6.3 0.1 2.2 2 0 0 2 2 2 0 AAA ATPase domain AAA_14 PF13173.6 CCF44599.1 - 0.2 11.7 0.1 3.5 7.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 CCF44599.1 - 0.2 11.4 0.7 4.1 7.1 0.0 2.5 2 1 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 CCF44599.1 - 0.21 11.3 0.6 2 8.1 0.2 2.6 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase AAA_18 PF13238.6 CCF44599.1 - 0.81 10.2 3.2 2.6 8.6 0.2 2.7 2 1 0 2 2 2 0 AAA domain zf-RING_UBOX PF13445.6 CCF44600.1 - 1.4e-07 31.4 10.3 0.00055 19.9 4.1 2.6 2 0 0 2 2 2 2 RING-type zinc-finger zf-NOSIP PF15906.5 CCF44600.1 - 3.2e-06 27.2 0.0 9.7e-06 25.6 0.0 1.8 2 0 0 2 2 2 1 Zinc-finger of nitric oxide synthase-interacting protein zf-RING_2 PF13639.6 CCF44600.1 - 5.4e-06 26.7 12.7 0.0011 19.3 4.3 2.6 2 0 0 2 2 2 2 Ring finger domain zf-C3HC4_2 PF13923.6 CCF44600.1 - 2.5e-05 24.0 11.7 0.0023 17.8 0.8 3.1 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CCF44600.1 - 9.3e-05 22.2 14.5 0.022 14.6 4.6 2.7 2 1 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CCF44600.1 - 0.00012 22.0 4.4 0.00012 22.0 4.4 2.5 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 CCF44600.1 - 0.00086 19.4 14.6 0.081 13.1 1.8 2.9 2 1 0 2 2 2 2 zinc finger of C3HC4-type, RING BOP1NT PF08145.12 CCF44600.1 - 0.0097 15.9 2.7 0.013 15.4 2.7 1.2 1 0 0 1 1 1 1 BOP1NT (NUC169) domain FYVE PF01363.21 CCF44600.1 - 0.011 15.9 11.3 0.016 15.4 5.2 2.6 2 1 0 2 2 2 0 FYVE zinc finger Ribosomal_L40e PF01020.17 CCF44600.1 - 0.35 10.8 0.1 0.35 10.8 0.1 3.1 2 1 1 3 3 3 0 Ribosomal L40e family zf-AD PF07776.15 CCF44600.1 - 0.78 10.0 0.0 0.78 10.0 0.0 3.7 3 2 0 3 3 3 0 Zinc-finger associated domain (zf-AD) RGS_DHEX PF18148.1 CCF44600.1 - 1 9.5 4.5 5.5 7.2 1.3 2.7 2 0 0 2 2 2 0 Regulator of G-protein signalling DHEX domain Fer2 PF00111.27 CCF44600.1 - 1.8 8.6 11.3 11 6.1 0.3 3.3 2 1 1 3 3 3 0 2Fe-2S iron-sulfur cluster binding domain IBR PF01485.21 CCF44600.1 - 3.1 8.1 10.8 0.3 11.3 0.9 2.8 3 0 0 3 3 2 0 IBR domain, a half RING-finger domain Prok-RING_4 PF14447.6 CCF44600.1 - 3.6 7.5 19.3 5.6 6.9 8.3 3.6 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 RCSD PF05177.12 CCF44600.1 - 8.4 7.4 10.7 0.16 12.9 2.7 2.3 2 1 0 2 2 2 0 RCSD region Mito_carr PF00153.27 CCF44601.1 - 7.3e-12 45.1 0.9 2.2e-11 43.5 0.9 1.7 1 1 0 1 1 1 1 Mitochondrial carrier protein SRP-alpha_N PF04086.13 CCF44603.1 - 1.2e-67 228.9 0.0 1.6e-67 228.5 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal YIF1 PF03878.15 CCF44604.1 - 1.6e-33 116.2 0.7 2e-33 115.9 0.7 1.1 1 0 0 1 1 1 1 YIF1 ABC2_membrane PF01061.24 CCF44605.1 - 6.3e-39 133.6 31.6 8e-37 126.7 21.9 3.1 3 0 0 3 3 3 2 ABC-2 type transporter PDR_CDR PF06422.12 CCF44605.1 - 3.6e-32 110.1 0.0 1.5e-31 108.1 0.0 2.1 1 0 0 1 1 1 1 CDR ABC transporter ABC_tran PF00005.27 CCF44605.1 - 9.9e-17 61.7 0.1 2.1e-16 60.7 0.0 1.6 2 0 0 2 2 1 1 ABC transporter AAA_25 PF13481.6 CCF44605.1 - 3.7e-05 23.4 0.3 0.00013 21.7 0.2 1.8 1 1 1 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 CCF44605.1 - 0.00011 22.2 0.3 0.00056 19.9 0.1 2.2 3 0 0 3 3 3 1 RsgA GTPase AAA_21 PF13304.6 CCF44605.1 - 0.00048 20.0 0.1 1 9.1 0.1 2.7 2 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CCF44605.1 - 0.00061 19.5 0.2 0.011 15.5 0.1 2.4 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_18 PF13238.6 CCF44605.1 - 0.0012 19.4 0.0 0.0022 18.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CCF44605.1 - 0.0024 18.3 0.1 0.0046 17.4 0.1 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 CCF44605.1 - 0.028 14.6 0.1 0.058 13.6 0.1 1.5 1 0 0 1 1 1 0 AAA domain SMC_N PF02463.19 CCF44605.1 - 0.047 13.1 0.0 2.1 7.7 0.0 2.1 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain cobW PF02492.19 CCF44605.1 - 0.062 12.9 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain SLC12 PF03522.15 CCF44606.1 - 1.5e-09 37.4 0.1 2.2e-09 36.9 0.1 1.2 1 0 0 1 1 1 1 Solute carrier family 12 Involucrin_N PF10583.9 CCF44608.1 - 0.026 15.1 0.7 0.026 15.1 0.7 2.9 3 1 0 3 3 3 0 Involucrin of squamous epithelia N-terminus Aldedh PF00171.22 CCF44610.1 - 3.4e-98 329.2 0.0 4.2e-98 328.9 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF4609 PF15382.6 CCF44612.1 - 0.081 12.8 0.2 0.11 12.4 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4609) adh_short_C2 PF13561.6 CCF44613.1 - 1e-57 195.4 4.3 1.2e-57 195.2 4.3 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF44613.1 - 3.4e-48 163.7 2.5 4.5e-48 163.3 2.5 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF44613.1 - 4.8e-12 46.2 0.6 1.2e-11 44.8 0.6 1.6 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 CCF44613.1 - 0.0044 16.2 0.1 0.0062 15.7 0.1 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein MFS_1 PF07690.16 CCF44614.1 - 6.1e-16 58.3 11.4 6.9e-16 58.1 11.4 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 CCF44614.1 - 0.00058 19.3 3.9 0.00071 19.0 3.9 1.1 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB Herpes_LMP1 PF05297.11 CCF44615.1 - 4.7 6.3 7.7 5.6 6.1 7.7 1.0 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) CIAPIN1 PF05093.13 CCF44616.1 - 4.8e-42 142.5 2.3 7.8e-42 141.9 2.3 1.3 1 0 0 1 1 1 1 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis DRE2_N PF16803.5 CCF44616.1 - 2.1e-36 125.1 0.1 2.9e-36 124.6 0.1 1.2 1 0 0 1 1 1 1 Fe-S cluster assembly protein DRE2 N-terminus Hom_end PF05204.14 CCF44616.1 - 0.044 14.0 0.0 0.12 12.6 0.0 1.7 1 0 0 1 1 1 0 Homing endonuclease E1_FCCH PF16190.5 CCF44618.1 - 2.1e-32 111.1 0.9 7.8e-32 109.3 0.2 2.3 3 0 0 3 3 3 1 Ubiquitin-activating enzyme E1 FCCH domain ThiF PF00899.21 CCF44618.1 - 4.9e-31 107.9 0.0 6.5e-31 107.5 0.0 1.1 1 0 0 1 1 1 1 ThiF family E1_4HB PF16191.5 CCF44618.1 - 1.9e-17 63.2 0.4 3.6e-17 62.3 0.4 1.5 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 four-helix bundle SOBP PF15279.6 CCF44619.1 - 0.00041 21.1 6.4 0.00041 21.1 6.4 1.1 1 0 0 1 1 1 1 Sine oculis-binding protein Glyco_hydro_76 PF03663.14 CCF44621.1 - 1.1e-85 288.4 4.7 1.3e-85 288.1 4.7 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Fungal_trans_2 PF11951.8 CCF44623.1 - 2.4e-08 33.2 0.3 3.5e-08 32.7 0.3 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain E1-E2_ATPase PF00122.20 CCF44624.1 - 2.9e-38 131.2 16.5 3.2e-31 108.2 0.2 3.7 4 0 0 4 4 4 2 E1-E2 ATPase Cation_ATPase_C PF00689.21 CCF44624.1 - 1.5e-26 93.2 8.0 1.5e-26 93.2 8.0 2.5 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 CCF44624.1 - 1.5e-20 74.4 0.0 1.1e-19 71.5 0.0 2.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CCF44624.1 - 1.1e-19 70.3 0.0 2.3e-19 69.3 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 CCF44624.1 - 2e-15 56.2 0.0 6.1e-15 54.7 0.0 1.9 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 CCF44624.1 - 0.0011 18.8 0.1 0.013 15.2 0.2 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF2417 PF10329.9 CCF44625.1 - 6.3e-16 58.5 0.2 9e-16 58.0 0.2 1.2 1 0 0 1 1 1 1 Region of unknown function (DUF2417) AA_permease_2 PF13520.6 CCF44626.1 - 2.6e-39 135.3 35.1 3.3e-39 134.9 35.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CCF44626.1 - 1.8e-18 66.4 30.2 2.3e-18 66.0 30.2 1.1 1 0 0 1 1 1 1 Amino acid permease Baculo_helicase PF04735.12 CCF44626.1 - 0.15 9.6 0.1 0.2 9.2 0.1 1.0 1 0 0 1 1 1 0 Baculovirus DNA helicase GAPT PF11770.8 CCF44626.1 - 0.18 11.6 0.2 0.35 10.7 0.2 1.4 1 0 0 1 1 1 0 GRB2-binding adapter (GAPT) MFS_1 PF07690.16 CCF44628.1 - 2e-30 105.9 18.7 2.5e-30 105.6 18.7 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 CCF44628.1 - 0.00027 20.3 4.9 0.00038 19.9 4.9 1.1 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB Suf PF05843.14 CCF44630.1 - 3.7e-78 263.5 0.0 5.8e-77 259.6 0.0 2.2 1 1 0 1 1 1 1 Suppressor of forked protein (Suf) HgmA PF04209.13 CCF44634.1 - 7.8e-166 552.0 0.0 9.1e-166 551.8 0.0 1.0 1 0 0 1 1 1 1 homogentisate 1,2-dioxygenase Dicty_REP PF05086.12 CCF44635.1 - 0.43 8.5 3.5 0.38 8.7 3.5 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein PRR18 PF15671.5 CCF44635.1 - 3.3 7.5 10.0 4.5 7.1 10.0 1.2 1 0 0 1 1 1 0 Proline-rich protein family 18 DUF3439 PF11921.8 CCF44635.1 - 6.7 6.7 10.2 9.5 6.2 10.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Acetyltransf_9 PF13527.7 CCF44640.1 - 8.5e-07 29.1 0.1 1.8e-06 28.0 0.1 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CCF44640.1 - 0.00028 21.1 0.0 0.001 19.3 0.0 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_13 PF13880.6 CCF44640.1 - 0.0035 17.3 0.0 0.0098 15.8 0.0 1.7 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase Acetyltransf_7 PF13508.7 CCF44640.1 - 0.0037 17.7 0.0 0.0076 16.7 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CCF44640.1 - 0.0046 16.9 0.0 0.0096 15.9 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 CCF44640.1 - 0.11 12.0 0.0 0.16 11.4 0.0 1.1 1 0 0 1 1 1 0 Putative acetyl-transferase FR47 PF08445.10 CCF44640.1 - 0.11 12.5 0.0 0.37 10.8 0.0 1.9 1 1 0 1 1 1 0 FR47-like protein Sas10_Utp3 PF04000.15 CCF44641.1 - 3.6e-05 24.3 1.0 4.4e-05 24.0 1.0 1.1 1 0 0 1 1 1 1 Sas10/Utp3/C1D family Snapin_Pallidin PF14712.6 CCF44641.1 - 0.086 13.3 0.1 0.1 13.1 0.1 1.1 1 0 0 1 1 1 0 Snapin/Pallidin ApbA_C PF08546.11 CCF44642.1 - 1.3e-16 60.9 0.0 3e-16 59.7 0.0 1.6 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 CCF44642.1 - 1.9e-09 37.3 0.0 3.3e-09 36.5 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA RNase_PH PF01138.21 CCF44643.1 - 6.2e-15 55.9 0.0 9.1e-15 55.3 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 zf_CCCH_4 PF18345.1 CCF44644.1 - 9.1e-09 35.1 33.6 0.00027 20.9 0.6 6.1 5 1 0 5 5 5 4 Zinc finger domain zf-CCCH PF00642.24 CCF44644.1 - 9.2e-09 35.0 28.0 0.00031 20.6 0.2 5.5 4 1 1 5 5 5 5 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 CCF44644.1 - 0.0018 18.0 0.1 0.0018 18.0 0.1 5.5 5 1 0 5 5 5 2 CCCH-type zinc finger Torus PF16131.5 CCF44644.1 - 0.0022 18.7 24.6 0.11 13.2 0.2 5.0 2 1 3 5 5 5 3 Torus domain zf-CCCH_3 PF15663.5 CCF44644.1 - 0.0061 16.8 18.1 0.29 11.4 4.4 3.5 1 1 0 2 2 2 2 Zinc-finger containing family zf-C3H1 PF10650.9 CCF44644.1 - 0.11 12.3 9.2 3.4 7.5 0.0 4.3 4 0 0 4 4 4 0 Putative zinc-finger domain SURF2 PF05477.11 CCF44644.1 - 0.25 11.0 4.2 1.1 8.9 1.3 2.1 2 0 0 2 2 2 0 Surfeit locus protein 2 (SURF2) Amidase PF01425.21 CCF44645.1 - 9.2e-59 199.6 2.5 6.2e-54 183.7 0.5 2.2 1 1 1 2 2 2 2 Amidase DUF3759 PF12585.8 CCF44646.1 - 0.058 13.4 4.9 0.1 12.7 4.8 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3759) FUSC_2 PF13515.6 CCF44647.1 - 0.01 16.0 0.3 0.011 15.9 0.3 1.1 1 0 0 1 1 1 1 Fusaric acid resistance protein-like 2HCT PF03390.15 CCF44647.1 - 0.011 14.4 0.1 0.012 14.2 0.1 1.0 1 0 0 1 1 1 0 2-hydroxycarboxylate transporter family DUF4083 PF13314.6 CCF44647.1 - 0.072 13.0 0.1 0.095 12.7 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4083) Methyltransf_32 PF13679.6 CCF44648.1 - 2.3e-21 76.4 0.0 4.7e-21 75.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CCF44648.1 - 0.0003 20.4 0.0 0.00083 18.9 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_31 PF13847.6 CCF44648.1 - 0.0013 18.5 0.0 0.0024 17.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF44648.1 - 0.0051 17.5 0.0 0.013 16.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain GidB PF02527.15 CCF44648.1 - 0.0078 15.6 0.0 0.014 14.7 0.0 1.4 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G Methyltransf_12 PF08242.12 CCF44648.1 - 0.028 15.2 0.0 0.075 13.8 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_4 PF02390.17 CCF44648.1 - 0.054 13.0 0.0 0.091 12.2 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase Pkinase PF00069.25 CCF44653.1 - 2e-71 240.5 0.0 3.7e-71 239.6 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF44653.1 - 2.6e-49 167.8 0.0 4.5e-49 167.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CCF44653.1 - 4.8e-05 22.3 0.3 9.4e-05 21.4 0.0 1.5 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 CCF44653.1 - 0.0026 17.1 0.0 0.025 13.9 0.1 2.2 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 CCF44653.1 - 0.14 11.5 0.0 0.26 10.6 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Caskin1-CID PF16600.5 CCF44653.1 - 1.1 9.8 3.9 3.9 8.1 3.9 1.9 1 0 0 1 1 1 0 Caskin1 CASK-interaction domain DUF952 PF06108.12 CCF44654.1 - 3.5e-14 52.6 0.0 4.4e-14 52.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF952) AMP-binding PF00501.28 CCF44655.1 - 2.1e-23 82.6 0.1 2.7e-23 82.3 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CCF44655.1 - 1.1e-14 55.2 0.8 2e-14 54.3 0.8 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Ferric_reduct PF01794.19 CCF44656.1 - 1.5e-19 70.3 14.8 4.5e-19 68.8 14.8 1.9 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 CCF44656.1 - 0.026 14.6 0.1 0.081 13.0 0.1 1.8 2 0 0 2 2 2 0 FAD-binding domain SOG2 PF10428.9 CCF44657.1 - 1.7 7.7 10.9 1.9 7.6 10.9 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein IBB PF01749.20 CCF44657.1 - 2.2 8.8 6.7 2.3 8.7 4.1 2.3 2 1 0 2 2 2 0 Importin beta binding domain FAD_binding_8 PF08022.12 CCF44658.1 - 1e-17 64.2 1.4 1.8e-17 63.4 0.0 2.0 2 0 0 2 2 2 1 FAD-binding domain Ferric_reduct PF01794.19 CCF44658.1 - 1.2e-17 64.2 11.4 1.2e-17 64.2 11.4 2.3 1 1 1 2 2 2 2 Ferric reductase like transmembrane component DUF572 PF04502.13 CCF44659.1 - 7.9e-66 222.9 8.3 9.2e-66 222.7 8.3 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) DUF951 PF06107.11 CCF44659.1 - 0.1 12.5 0.8 15 5.6 0.1 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF951) Dynamitin PF04912.14 CCF44659.1 - 0.31 10.3 10.8 0.57 9.5 10.7 1.5 1 1 0 1 1 1 0 Dynamitin zf-ACC PF17848.1 CCF44659.1 - 0.43 10.7 4.0 9.9 6.3 1.0 2.5 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain PIN_12 PF16289.5 CCF44660.1 - 0.069 13.6 1.0 0.12 12.9 1.0 1.4 1 0 0 1 1 1 0 PIN domain His_Phos_1 PF00300.22 CCF44662.1 - 5.1e-09 36.1 0.5 6.7e-09 35.7 0.5 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) MFS_1 PF07690.16 CCF44666.1 - 1.1e-45 156.1 27.5 1.1e-45 156.1 27.5 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF44666.1 - 4.6e-13 48.8 7.3 4.6e-13 48.8 7.3 2.7 3 0 0 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.13 CCF44666.1 - 3.7e-05 22.4 5.8 6.1e-05 21.6 5.8 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_1_like PF12832.7 CCF44666.1 - 0.00019 20.5 1.5 0.00019 20.5 1.5 2.4 2 1 0 3 3 3 1 MFS_1 like family MFS_3 PF05977.13 CCF44666.1 - 0.001 17.6 2.5 0.001 17.6 2.5 2.1 2 0 0 2 2 2 1 Transmembrane secretion effector MFS_2 PF13347.6 CCF44666.1 - 0.28 9.7 15.6 0.0065 15.1 6.3 2.5 2 1 0 2 2 2 0 MFS/sugar transport protein OATP PF03137.20 CCF44666.1 - 0.69 8.1 9.3 1.8 6.7 0.2 2.7 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family Methyltransf_11 PF08241.12 CCF44668.1 - 7.6e-08 32.9 0.0 2.5e-05 24.8 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF44668.1 - 3.4e-07 30.9 0.0 0.0023 18.6 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_23 PF13489.6 CCF44668.1 - 5.3e-05 23.1 0.0 7.7e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF44668.1 - 0.0027 18.4 0.0 0.035 14.9 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF44668.1 - 0.0083 15.9 0.0 0.67 9.7 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain PRIMA1 PF16101.5 CCF44668.1 - 0.016 15.3 1.1 0.029 14.4 1.1 1.5 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Metallophos PF00149.28 CCF44670.1 - 1.6e-37 130.0 0.1 3.5e-37 128.9 0.0 1.6 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase SH3_11 PF18103.1 CCF44671.1 - 0.12 12.6 0.0 0.38 11.0 0.0 1.9 1 0 0 1 1 1 0 Retroviral integrase C-terminal SH3 domain Tyrosinase PF00264.20 CCF44672.1 - 3.2e-48 165.0 0.1 4e-48 164.6 0.1 1.1 1 0 0 1 1 1 1 Common central domain of tyrosinase adh_short_C2 PF13561.6 CCF44673.1 - 2.6e-39 135.2 0.0 3e-39 135.0 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF44673.1 - 2e-25 89.4 0.0 2.3e-25 89.2 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase Spt20 PF12090.8 CCF44674.1 - 0.14 11.7 13.4 0.15 11.6 13.4 1.0 1 0 0 1 1 1 0 Spt20 family HTH_28 PF13518.6 CCF44675.1 - 0.0044 17.1 0.8 0.014 15.5 0.7 2.0 1 1 0 1 1 1 1 Helix-turn-helix domain HTH_Tnp_IS630 PF01710.16 CCF44675.1 - 0.054 13.5 0.8 0.11 12.5 0.7 1.5 1 1 0 1 1 1 0 Transposase DUF1699 PF08004.11 CCF44675.1 - 0.13 12.0 0.0 0.21 11.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1699) HTH_23 PF13384.6 CCF44675.1 - 0.2 11.5 3.2 0.1 12.4 0.7 2.0 2 0 0 2 2 2 0 Homeodomain-like domain Pkinase PF00069.25 CCF44676.1 - 4.1e-39 134.5 0.0 7.2e-39 133.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF44676.1 - 5.2e-21 75.1 0.0 7.9e-21 74.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF44676.1 - 1.4e-07 31.1 0.3 0.00015 21.2 0.0 2.5 3 0 0 3 3 3 2 Kinase-like APH PF01636.23 CCF44676.1 - 9e-06 25.8 0.4 0.0017 18.4 0.1 3.3 3 1 1 4 4 4 1 Phosphotransferase enzyme family PAS_9 PF13426.7 CCF44676.1 - 0.00071 19.8 0.0 0.0018 18.5 0.0 1.7 1 0 0 1 1 1 1 PAS domain Haspin_kinase PF12330.8 CCF44676.1 - 0.0046 15.9 0.0 0.0087 15.0 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Seadorna_VP7 PF07387.11 CCF44676.1 - 0.0057 15.7 0.0 0.0092 15.1 0.0 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 Kdo PF06293.14 CCF44676.1 - 0.0068 15.8 0.0 0.012 14.9 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family PAS PF00989.25 CCF44676.1 - 0.016 15.2 0.1 0.09 12.8 0.0 2.2 1 1 1 2 2 2 0 PAS fold PAS_4 PF08448.10 CCF44676.1 - 0.027 14.7 0.0 0.068 13.4 0.0 1.7 1 0 0 1 1 1 0 PAS fold PAS_9 PF13426.7 CCF44677.1 - 6.4e-13 48.9 0.0 1.7e-12 47.5 0.0 1.8 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.10 CCF44677.1 - 3.9e-07 30.3 0.1 3.1e-06 27.4 0.0 2.4 2 0 0 2 2 2 1 PAS fold RGS PF00615.19 CCF44677.1 - 0.0011 19.2 0.5 0.017 15.4 0.0 2.7 2 1 0 2 2 2 1 Regulator of G protein signaling domain PAS PF00989.25 CCF44677.1 - 0.0016 18.4 0.0 0.005 16.8 0.0 1.8 1 0 0 1 1 1 1 PAS fold DUF2828 PF11443.8 CCF44677.1 - 0.083 11.0 0.6 0.11 10.5 0.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) MAJIN PF15077.6 CCF44677.1 - 0.3 10.9 7.9 0.48 10.2 7.9 1.2 1 0 0 1 1 1 0 Membrane-anchored junction protein Presenilin PF01080.17 CCF44677.1 - 8.3 5.1 6.1 12 4.6 6.1 1.1 1 0 0 1 1 1 0 Presenilin MFS_1 PF07690.16 CCF44678.1 - 1.1e-08 34.4 34.5 1.1e-08 34.4 34.5 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily UNC-93 PF05978.16 CCF44678.1 - 3.5e-06 26.8 3.6 3.5e-06 26.8 3.6 3.0 3 0 0 3 3 3 2 Ion channel regulatory protein UNC-93 YadA_anchor PF03895.15 CCF44679.1 - 0.11 12.6 0.6 0.24 11.6 0.6 1.4 1 0 0 1 1 1 0 YadA-like membrane anchor domain DUF1295 PF06966.12 CCF44680.1 - 7.6e-19 68.2 0.0 1.1e-18 67.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) ICMT PF04140.14 CCF44680.1 - 0.0001 22.7 0.0 0.00021 21.7 0.0 1.6 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family Steroid_dh PF02544.16 CCF44680.1 - 0.0015 18.6 0.0 0.0021 18.1 0.0 1.3 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase PEMT PF04191.13 CCF44680.1 - 0.0045 17.4 0.1 0.0087 16.4 0.1 1.5 1 0 0 1 1 1 1 Phospholipid methyltransferase ERG4_ERG24 PF01222.17 CCF44680.1 - 0.016 14.0 0.0 0.019 13.8 0.0 1.2 1 0 0 1 1 1 0 Ergosterol biosynthesis ERG4/ERG24 family DUF2062 PF09835.9 CCF44680.1 - 0.032 14.1 0.1 0.063 13.1 0.1 1.7 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2062) NDT80_PhoG PF05224.12 CCF44681.1 - 1.3e-33 116.8 0.0 1.1e-32 113.7 0.0 2.0 2 0 0 2 2 2 1 NDT80 / PhoG like DNA-binding family bZIP_1 PF00170.21 CCF44682.1 - 0.017 15.2 9.2 0.017 15.2 9.2 2.2 1 1 0 2 2 2 0 bZIP transcription factor Tma16 PF11176.8 CCF44682.1 - 0.031 14.2 3.4 0.047 13.6 3.4 1.2 1 0 0 1 1 1 0 Translation machinery-associated protein 16 DUF3213 PF11491.8 CCF44682.1 - 0.3 11.3 1.0 0.54 10.5 1.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3213) BST2 PF16716.5 CCF44682.1 - 0.42 11.2 4.9 0.71 10.5 4.9 1.3 1 0 0 1 1 1 0 Bone marrow stromal antigen 2 FapA PF03961.13 CCF44682.1 - 0.51 8.9 2.0 0.67 8.5 2.0 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A GMC_oxred_C PF05199.13 CCF44684.1 - 8.5e-21 75.0 0.0 9.3e-21 74.9 0.0 1.0 1 0 0 1 1 1 1 GMC oxidoreductase Glyco_hydro_28 PF00295.17 CCF44685.1 - 2.2e-05 23.7 0.0 2.8e-05 23.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Ribosomal_L5e PF17144.4 CCF44686.1 - 1.1e-78 262.8 0.2 2.1e-78 261.9 0.2 1.4 1 0 0 1 1 1 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.6 CCF44686.1 - 1.8e-35 121.8 10.5 1.8e-35 121.8 10.5 1.7 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region Uteroglobin PF01099.17 CCF44686.1 - 4.5 7.7 4.8 2.9 8.3 0.2 2.2 2 0 0 2 2 2 0 Uteroglobin family HAD_2 PF13419.6 CCF44687.1 - 0.0052 16.9 0.0 0.008 16.3 0.0 1.4 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Methyltransf_31 PF13847.6 CCF44688.1 - 1.3e-19 70.5 0.0 2.3e-19 69.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF44688.1 - 6.3e-18 65.3 0.0 2.4e-17 63.4 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF44688.1 - 2.3e-16 60.2 0.0 9.2e-16 58.3 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF44688.1 - 2.8e-14 53.6 0.0 7.4e-14 52.3 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCF44688.1 - 4.1e-14 52.5 0.0 2e-13 50.2 0.0 1.8 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 CCF44688.1 - 1.9e-09 37.6 0.0 2.9e-09 37.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 CCF44688.1 - 2.4e-05 24.2 0.0 5.6e-05 23.0 0.0 1.5 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TPMT PF05724.11 CCF44688.1 - 4e-05 23.4 0.0 7e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_24 PF13578.6 CCF44688.1 - 0.0015 19.6 0.0 0.0036 18.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 CCF44688.1 - 0.0016 18.6 0.0 0.0041 17.3 0.0 1.7 1 1 0 1 1 1 1 FtsJ-like methyltransferase CheR PF01739.18 CCF44688.1 - 0.0019 17.7 0.0 1.2 8.6 0.0 2.2 1 1 0 2 2 2 2 CheR methyltransferase, SAM binding domain UPF0020 PF01170.18 CCF44688.1 - 0.0078 15.9 0.0 0.015 15.0 0.0 1.5 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 SAM_2 PF07647.17 CCF44689.1 - 3.6e-14 52.6 0.0 8.2e-14 51.5 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_9 PF14604.6 CCF44689.1 - 1.6e-13 50.3 0.0 4.9e-13 48.7 0.0 1.9 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 CCF44689.1 - 2.7e-10 39.7 0.0 6e-10 38.6 0.0 1.6 1 0 0 1 1 1 1 SH3 domain PH PF00169.29 CCF44689.1 - 5.5e-10 39.7 0.0 1.3e-09 38.5 0.0 1.7 1 0 0 1 1 1 1 PH domain SH3_2 PF07653.17 CCF44689.1 - 0.00028 20.5 0.0 0.00059 19.5 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain PH_11 PF15413.6 CCF44689.1 - 0.0033 17.8 0.1 0.0089 16.4 0.1 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain SAM_1 PF00536.30 CCF44689.1 - 0.052 14.0 0.0 0.1 13.0 0.0 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) PH_8 PF15409.6 CCF44689.1 - 0.084 13.2 0.0 0.52 10.6 0.0 2.1 2 0 0 2 2 2 0 Pleckstrin homology domain TAF6_C PF07571.13 CCF44690.1 - 1e-27 96.3 0.0 2.1e-27 95.3 0.0 1.6 1 0 0 1 1 1 1 TAF6 C-terminal HEAT repeat domain TAF PF02969.17 CCF44690.1 - 9e-22 77.0 0.0 2.2e-21 75.8 0.0 1.7 2 0 0 2 2 2 1 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.23 CCF44690.1 - 0.0057 16.9 0.0 0.016 15.5 0.0 1.8 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 CCF44690.1 - 0.017 15.4 0.1 0.028 14.8 0.1 1.3 1 0 0 1 1 1 0 Core histone H2A/H2B/H3/H4 Bromo_TP PF07524.13 CCF44690.1 - 0.11 12.6 0.0 0.24 11.4 0.0 1.5 1 0 0 1 1 1 0 Bromodomain associated Sex_peptide PF08138.11 CCF44691.1 - 0.092 12.9 0.3 0.13 12.4 0.3 1.3 1 1 0 1 1 1 0 Sex peptide (SP) family Ofd1_CTDD PF10637.9 CCF44692.1 - 1.9e-95 319.1 0.0 5.1e-90 301.3 0.0 2.1 2 0 0 2 2 2 2 Oxoglutarate and iron-dependent oxygenase degradation C-term 2OG-FeII_Oxy_4 PF13661.6 CCF44692.1 - 1.9e-25 89.4 0.0 8.4e-25 87.3 0.0 2.1 2 1 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.6 CCF44692.1 - 1.2e-12 48.6 0.0 2.7e-12 47.4 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Lyase_1 PF00206.20 CCF44693.1 - 2e-57 195.0 0.0 2.6e-57 194.6 0.0 1.1 1 0 0 1 1 1 1 Lyase CYLD_phos_site PF16607.5 CCF44693.1 - 0.35 10.7 3.7 0.6 10.0 3.7 1.3 1 0 0 1 1 1 0 Phosphorylation region of CYLD, unstructured Fungal_trans PF04082.18 CCF44694.1 - 2.4e-11 43.2 0.2 4.7e-11 42.2 0.2 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain RskA PF10099.9 CCF44695.1 - 0.46 10.7 6.9 1.4 9.2 6.9 1.8 1 0 0 1 1 1 0 Anti-sigma-K factor rskA Glyco_hydro_76 PF03663.14 CCF44696.1 - 1e-84 285.2 9.4 1.1e-84 285.0 9.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Polyoma_coat PF00718.20 CCF44696.1 - 0.11 11.8 0.0 0.15 11.3 0.0 1.1 1 0 0 1 1 1 0 Polyomavirus coat protein SAP PF02037.27 CCF44697.1 - 5.3e-13 48.4 0.3 6.7e-13 48.1 0.3 1.1 1 0 0 1 1 1 1 SAP domain HeH PF12949.7 CCF44697.1 - 0.0082 15.8 0.2 0.016 14.9 0.2 1.5 1 1 0 1 1 1 1 HeH/LEM domain Metallophos PF00149.28 CCF44699.1 - 7.8e-16 59.2 0.1 1.5e-15 58.3 0.1 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Tyrosinase PF00264.20 CCF44701.1 - 1.3e-40 140.0 0.5 2.6e-40 139.1 0.5 1.5 1 0 0 1 1 1 1 Common central domain of tyrosinase Cyt-b5 PF00173.28 CCF44703.1 - 2.4e-16 59.6 0.0 4.8e-16 58.7 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain NAD_binding_1 PF00175.21 CCF44703.1 - 0.02 15.5 0.0 0.082 13.6 0.0 2.1 1 1 0 1 1 1 0 Oxidoreductase NAD-binding domain PBP1_TM PF14812.6 CCF44703.1 - 0.14 12.5 11.1 10 6.5 1.6 3.5 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal SPX PF03105.19 CCF44703.1 - 0.15 11.9 9.4 0.07 13.0 4.1 2.2 2 0 0 2 2 2 0 SPX domain CAF1A PF12253.8 CCF44705.1 - 1.5e-20 73.1 3.3 1.5e-20 73.1 3.3 3.6 3 1 0 3 3 3 1 Chromatin assembly factor 1 subunit A DUF4778 PF16008.5 CCF44705.1 - 0.22 11.6 9.7 0.34 10.9 9.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4778) Macoilin PF09726.9 CCF44705.1 - 0.52 8.8 12.6 0.64 8.5 12.6 1.1 1 0 0 1 1 1 0 Macoilin family LAP1C PF05609.12 CCF44705.1 - 2.3 7.2 18.9 3.6 6.6 18.9 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DUF3292 PF11696.8 CCF44705.1 - 3.9 5.7 20.2 6 5.1 20.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) Hamartin PF04388.12 CCF44705.1 - 4 6.0 32.9 3.4 6.2 22.2 2.0 1 1 1 2 2 2 0 Hamartin protein Presenilin PF01080.17 CCF44705.1 - 4.7 5.9 16.6 7.8 5.2 16.6 1.4 1 0 0 1 1 1 0 Presenilin SAPS PF04499.15 CCF44705.1 - 5.6 5.6 11.2 0.43 9.3 6.2 1.7 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein DUF966 PF06136.13 CCF44705.1 - 8.8 5.9 21.3 14 5.2 21.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF966) adh_short PF00106.25 CCF44706.1 - 1.5e-14 53.9 0.1 1.7e-14 53.8 0.1 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF44706.1 - 5.6e-11 42.4 0.2 6.5e-11 42.2 0.2 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF44706.1 - 2.2e-07 31.0 0.1 2.5e-07 30.8 0.1 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF44706.1 - 1.2e-05 24.9 0.0 1.4e-05 24.7 0.0 1.0 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Shikimate_DH PF01488.20 CCF44706.1 - 2.9e-05 24.2 0.1 4.2e-05 23.6 0.1 1.3 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Pyr_redox_2 PF07992.14 CCF44706.1 - 0.011 15.0 0.2 0.014 14.6 0.2 1.3 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Polysacc_synt_2 PF02719.15 CCF44706.1 - 0.012 14.8 0.0 0.014 14.6 0.0 1.0 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein 2-Hacid_dh_C PF02826.19 CCF44706.1 - 0.015 14.7 0.3 0.026 13.9 0.2 1.4 1 1 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain THF_DHG_CYH_C PF02882.19 CCF44706.1 - 0.039 13.3 0.2 0.088 12.1 0.0 1.6 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Trp_halogenase PF04820.14 CCF44706.1 - 0.054 12.3 1.9 0.069 12.0 1.9 1.0 1 0 0 1 1 1 0 Tryptophan halogenase NAD_binding_7 PF13241.6 CCF44706.1 - 0.1 13.0 0.2 0.14 12.6 0.2 1.2 1 0 0 1 1 1 0 Putative NAD(P)-binding ThiF PF00899.21 CCF44706.1 - 0.29 10.5 3.9 1.7 7.9 1.3 2.0 1 1 1 2 2 2 0 ThiF family Amidoligase_2 PF12224.8 CCF44707.1 - 1.1e-17 64.5 0.0 3.2e-10 40.1 0.0 3.5 3 1 0 3 3 3 3 Putative amidoligase enzyme Catalase PF00199.19 CCF44710.1 - 1e-192 640.4 0.7 1.4e-192 639.9 0.7 1.1 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 CCF44710.1 - 9.2e-10 38.6 0.0 2e-09 37.5 0.0 1.5 1 0 0 1 1 1 1 Catalase-related immune-responsive DUF898 PF05987.13 CCF44711.1 - 0.0027 16.8 3.3 0.067 12.2 1.3 2.3 1 1 1 2 2 2 2 Bacterial protein of unknown function (DUF898) Na_Ca_ex PF01699.24 CCF44711.1 - 0.01 15.8 6.1 0.036 14.0 0.2 2.5 2 0 0 2 2 2 0 Sodium/calcium exchanger protein SLATT_5 PF18160.1 CCF44711.1 - 0.11 11.8 0.1 1.9 7.8 0.0 2.6 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 DUF350 PF03994.14 CCF44711.1 - 0.71 10.1 3.9 0.38 10.9 0.9 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF350) Fungal_trans PF04082.18 CCF44712.1 - 9.7e-14 51.0 1.4 2.3e-13 49.8 1.4 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF44712.1 - 5.4e-08 32.8 13.1 9.8e-08 32.0 13.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Clat_adaptor_s PF01217.20 CCF44712.1 - 0.047 13.6 0.0 0.12 12.3 0.0 1.6 1 0 0 1 1 1 0 Clathrin adaptor complex small chain Hit1_C PF18268.1 CCF44712.1 - 0.18 12.0 0.2 0.56 10.4 0.0 1.9 2 0 0 2 2 2 0 Hit1 C-terminal AA_permease PF00324.21 CCF44713.1 - 6.7e-36 123.9 18.0 1.1e-21 77.0 13.2 2.0 2 0 0 2 2 2 2 Amino acid permease ABM PF03992.16 CCF44714.1 - 0.0034 17.5 0.1 0.021 14.9 0.0 2.0 2 0 0 2 2 2 1 Antibiotic biosynthesis monooxygenase DUF4937 PF16291.5 CCF44714.1 - 0.045 14.0 0.1 0.1 12.8 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4937 CD52 PF15116.6 CCF44716.1 - 0.034 14.2 0.2 0.32 11.1 0.1 2.1 2 0 0 2 2 2 0 CAMPATH-1 antigen Zn_clus PF00172.18 CCF44717.1 - 2.8e-06 27.4 8.9 4.6e-06 26.7 8.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RALF PF05498.11 CCF44719.1 - 6.7e-06 27.0 2.6 8.7e-06 26.6 2.6 1.2 1 0 0 1 1 1 1 Rapid ALkalinization Factor (RALF) Ferric_reduct PF01794.19 CCF44721.1 - 3.5e-15 56.2 8.8 5.7e-15 55.5 8.8 1.4 1 0 0 1 1 1 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 CCF44721.1 - 7.9e-15 55.3 0.0 1.8e-14 54.2 0.0 1.6 2 0 0 2 2 2 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 CCF44721.1 - 1.9e-10 40.8 0.0 5.2e-10 39.4 0.0 1.8 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_1 PF00175.21 CCF44721.1 - 0.0023 18.6 0.1 0.071 13.8 0.0 2.3 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain MerC PF03203.14 CCF44721.1 - 0.24 11.9 5.1 0.65 10.5 5.0 1.8 1 1 0 1 1 1 0 MerC mercury resistance protein DUF3099 PF11298.8 CCF44721.1 - 0.3 11.3 2.0 0.67 10.1 2.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3099) PDT PF00800.18 CCF44723.1 - 5.9e-59 199.0 0.0 7.6e-59 198.6 0.0 1.1 1 0 0 1 1 1 1 Prephenate dehydratase ACT PF01842.25 CCF44723.1 - 0.00037 20.2 0.0 0.0036 17.0 0.0 2.4 2 1 0 2 2 2 1 ACT domain Pkinase PF00069.25 CCF44724.1 - 4.4e-68 229.5 0.0 7.8e-68 228.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF44724.1 - 6e-50 169.9 0.0 1e-49 169.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Ras_bdg_2 PF14847.6 CCF44724.1 - 1.5e-26 92.6 0.0 2.8e-26 91.8 0.0 1.4 1 0 0 1 1 1 1 Ras-binding domain of Byr2 SAM_1 PF00536.30 CCF44724.1 - 1.1e-15 57.8 0.1 2.1e-15 56.9 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 CCF44724.1 - 1.4e-15 57.2 0.2 3.9e-15 55.7 0.1 1.9 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) RA PF00788.23 CCF44724.1 - 1e-13 51.7 0.1 1.8e-13 50.9 0.1 1.4 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain Kinase-like PF14531.6 CCF44724.1 - 1.6e-06 27.7 0.0 0.0003 20.2 0.0 2.2 2 0 0 2 2 2 2 Kinase-like SAM_4 PF18017.1 CCF44724.1 - 0.0062 16.5 0.0 0.014 15.4 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Pkinase_fungal PF17667.1 CCF44724.1 - 0.01 14.7 0.0 0.018 13.8 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase SAM_PNT PF02198.16 CCF44724.1 - 0.12 12.4 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain Abhydrolase_6 PF12697.7 CCF44725.1 - 1.1e-17 65.4 3.4 1.4e-17 65.0 3.4 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CCF44725.1 - 0.00077 19.2 0.1 0.67 9.5 0.0 2.3 2 1 0 2 2 2 2 alpha/beta hydrolase fold DUF900 PF05990.12 CCF44725.1 - 0.041 13.4 0.0 0.059 12.9 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) SnoaL PF07366.12 CCF44727.1 - 2.2e-06 27.5 0.1 5e-06 26.3 0.1 1.6 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase SnoaL_2 PF12680.7 CCF44727.1 - 0.0001 22.9 0.1 0.00025 21.6 0.1 1.6 1 0 0 1 1 1 1 SnoaL-like domain BBE PF08031.12 CCF44729.1 - 0.037 14.1 0.0 0.097 12.8 0.0 1.8 1 0 0 1 1 1 0 Berberine and berberine like UBA PF00627.31 CCF44730.1 - 2.1e-07 30.7 2.5 4.2e-06 26.5 0.0 2.9 2 0 0 2 2 2 1 UBA/TS-N domain HOIP-UBA PF16678.5 CCF44730.1 - 0.017 15.1 0.0 0.027 14.5 0.0 1.2 1 0 0 1 1 1 0 HOIP UBA domain pair STI1 PF17830.1 CCF44730.1 - 0.2 11.6 23.0 0.16 11.9 3.4 3.2 3 0 0 3 3 3 0 STI1 domain GET2 PF08690.10 CCF44730.1 - 6.1 6.4 9.6 1.2 8.7 0.6 2.5 2 1 0 2 2 2 0 GET complex subunit GET2 NPR2 PF06218.11 CCF44731.1 - 2e-48 165.3 0.0 4.4e-48 164.1 0.0 1.5 1 1 0 1 1 1 1 Nitrogen permease regulator 2 Acyl_transf_1 PF00698.21 CCF44732.1 - 4.9e-21 75.5 0.2 7.1e-21 75.0 0.2 1.2 1 0 0 1 1 1 1 Acyl transferase domain KAsynt_C_assoc PF16197.5 CCF44732.1 - 8.1e-06 26.3 0.4 6.6e-05 23.3 0.0 2.6 3 0 0 3 3 3 1 Ketoacyl-synthetase C-terminal extension HOOK PF05622.12 CCF44733.1 - 0.00073 17.8 16.8 0.00073 17.8 16.8 3.1 2 1 1 3 3 3 1 HOOK protein MIF4G_like PF09088.11 CCF44733.1 - 0.054 13.3 0.6 0.15 11.8 0.1 1.9 2 0 0 2 2 2 0 MIF4G like DUF1490 PF07371.12 CCF44733.1 - 1.5 8.9 4.7 1 9.5 0.3 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1490) Tropomyosin_1 PF12718.7 CCF44733.1 - 1.7 8.8 85.8 0.2 11.8 6.9 5.4 2 2 3 5 5 5 0 Tropomyosin like MscS_porin PF12795.7 CCF44733.1 - 2.3 7.7 65.1 0.3 10.6 14.8 4.1 2 1 1 3 3 3 0 Mechanosensitive ion channel porin domain Fib_alpha PF08702.10 CCF44733.1 - 2.9 8.1 42.9 0.67 10.1 7.3 5.1 2 2 3 5 5 5 0 Fibrinogen alpha/beta chain family Phage_GP20 PF06810.11 CCF44733.1 - 4.3 7.1 59.7 0.13 12.0 3.0 6.0 2 2 5 7 7 7 0 Phage minor structural protein GP20 GIT_CC PF16559.5 CCF44733.1 - 6.1 6.8 14.8 0.85 9.5 0.2 4.2 4 0 0 4 4 4 0 GIT coiled-coil Rho guanine nucleotide exchange factor Hexokinase_2 PF03727.16 CCF44734.1 - 3.5e-47 160.9 0.0 4.3e-47 160.6 0.0 1.1 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 CCF44734.1 - 3e-32 112.2 0.0 4.5e-32 111.6 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Beta-lactamase PF00144.24 CCF44736.1 - 8.1e-28 97.6 1.4 1.1e-27 97.2 1.4 1.1 1 0 0 1 1 1 1 Beta-lactamase CLIP1_ZNF PF16641.5 CCF44737.1 - 8.2 6.4 8.2 1.7 8.6 4.5 1.9 2 0 0 2 2 2 0 CLIP1 zinc knuckle Per1 PF04080.13 CCF44738.1 - 1.1e-106 356.3 6.5 1.3e-106 356.1 6.5 1.0 1 0 0 1 1 1 1 Per1-like family Adeno_E4 PF05385.11 CCF44738.1 - 0.024 14.7 3.9 0.71 10.0 0.4 2.6 2 0 0 2 2 2 0 Mastadenovirus early E4 13 kDa protein DUF4401 PF14351.6 CCF44738.1 - 0.11 11.8 6.6 0.16 11.3 6.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4401) DUF1772 PF08592.11 CCF44739.1 - 3.5e-06 27.4 6.1 1e-05 25.8 4.0 2.5 2 1 0 2 2 2 1 Domain of unknown function (DUF1772) Methyltransf_23 PF13489.6 CCF44740.1 - 2.4e-16 60.0 0.0 3.6e-16 59.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF44740.1 - 3.4e-10 39.9 0.0 4.5e-09 36.3 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF44740.1 - 5.1e-10 39.9 0.0 1.4e-09 38.5 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF44740.1 - 1.1e-07 32.4 0.0 2.2e-07 31.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF44740.1 - 1.3e-07 32.3 0.0 7e-07 29.9 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 CCF44740.1 - 0.0032 16.9 0.0 0.016 14.7 0.0 2.1 3 0 0 3 3 3 1 Putative methyltransferase FtsJ PF01728.19 CCF44740.1 - 0.02 15.0 0.0 0.036 14.2 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase DUF4357 PF14267.6 CCF44740.1 - 0.033 14.1 0.0 0.062 13.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4357) MTS PF05175.14 CCF44740.1 - 0.047 13.2 0.0 0.083 12.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_16 PF10294.9 CCF44740.1 - 0.063 13.0 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase PCMT PF01135.19 CCF44740.1 - 0.076 12.8 0.0 0.81 9.4 0.0 2.1 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_2 PF00891.18 CCF44740.1 - 0.083 12.2 0.0 0.42 9.9 0.0 2.0 2 0 0 2 2 2 0 O-methyltransferase domain GidB PF02527.15 CCF44740.1 - 0.23 10.8 0.0 2.3 7.5 0.0 2.4 2 1 0 2 2 2 0 rRNA small subunit methyltransferase G Methyltransf_23 PF13489.6 CCF44741.1 - 8.8e-20 71.2 0.0 1.2e-19 70.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF44741.1 - 1.9e-12 47.3 0.0 9.7e-12 44.9 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF44741.1 - 3.1e-11 43.8 0.0 7.9e-11 42.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF44741.1 - 2e-08 34.8 0.0 3.4e-08 34.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF44741.1 - 4.7e-08 33.7 0.0 2.7e-07 31.3 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 CCF44741.1 - 0.00098 19.3 0.0 0.0015 18.7 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase CMAS PF02353.20 CCF44741.1 - 0.0073 15.6 0.0 0.034 13.5 0.0 1.8 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_4 PF02390.17 CCF44741.1 - 0.011 15.2 0.0 0.053 13.0 0.0 2.0 2 0 0 2 2 2 0 Putative methyltransferase MTS PF05175.14 CCF44741.1 - 0.028 14.0 0.0 0.064 12.8 0.0 1.5 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_16 PF10294.9 CCF44741.1 - 0.045 13.5 0.0 0.079 12.7 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase PrmA PF06325.13 CCF44741.1 - 0.053 12.9 0.0 0.08 12.3 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_2 PF00891.18 CCF44741.1 - 0.16 11.3 0.0 0.36 10.1 0.0 1.7 2 1 0 2 2 2 0 O-methyltransferase domain PCMT PF01135.19 CCF44741.1 - 0.18 11.5 0.0 1.1 8.9 0.0 2.0 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ubie_methyltran PF01209.18 CCF44741.1 - 0.19 11.1 0.0 1.4 8.2 0.0 2.1 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family LysM PF01476.20 CCF44743.1 - 2.5e-06 27.4 0.0 3.5e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 LysM domain MFS_1 PF07690.16 CCF44744.1 - 0.0044 16.0 1.9 0.011 14.7 1.9 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily BDV_G PF06208.11 CCF44744.1 - 0.011 15.0 0.0 0.014 14.6 0.0 1.1 1 0 0 1 1 1 0 Borna disease virus G protein ATG22 PF11700.8 CCF44744.1 - 0.014 14.1 0.0 0.017 13.8 0.0 1.2 1 0 0 1 1 1 0 Vacuole effluxer Atg22 like eIF-5a PF01287.20 CCF44746.1 - 2e-06 27.8 0.0 3.2e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold SNF PF00209.18 CCF44748.1 - 1.4e-22 80.2 11.4 1.4e-22 80.2 11.4 1.7 2 0 0 2 2 2 1 Sodium:neurotransmitter symporter family Dynactin_p22 PF07426.11 CCF44749.1 - 0.0065 16.3 0.0 0.015 15.2 0.0 1.5 2 0 0 2 2 2 1 Dynactin subunit p22 AviRa PF11599.8 CCF44753.1 - 0.16 11.4 0.0 0.19 11.1 0.0 1.2 1 0 0 1 1 1 0 RRNA methyltransferase AviRa Vps23_core PF09454.10 CCF44754.1 - 2.6e-23 81.7 0.0 3.7e-23 81.3 0.0 1.2 1 0 0 1 1 1 1 Vps23 core domain DUF3368 PF11848.8 CCF44754.1 - 0.4 10.5 2.7 1.1 9.1 0.0 2.8 4 0 0 4 4 4 0 Domain of unknown function (DUF3368) DUF1996 PF09362.10 CCF44755.1 - 1e-84 284.2 0.0 1.7e-84 283.5 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) WSC PF01822.19 CCF44755.1 - 1.7e-21 76.2 7.1 1.7e-21 76.2 7.1 2.6 3 0 0 3 3 3 1 WSC domain Rad21_Rec8 PF04824.16 CCF44757.1 - 1.1e-05 24.6 0.0 2.6e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein zf-RING_2 PF13639.6 CCF44758.1 - 2.2e-11 43.9 6.8 3.4e-11 43.3 6.8 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 CCF44758.1 - 7e-08 32.1 1.3 1.1e-07 31.4 1.3 1.3 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 CCF44758.1 - 7.7e-08 32.1 6.4 1.2e-07 31.4 6.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CCF44758.1 - 1e-07 31.7 4.2 1.6e-07 31.0 4.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 CCF44758.1 - 5.4e-06 26.6 9.8 2.6e-05 24.4 9.8 1.9 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 CCF44758.1 - 1.3e-05 25.0 3.8 2e-05 24.4 3.8 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 CCF44758.1 - 0.0017 18.4 1.7 0.0033 17.5 1.7 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 CCF44758.1 - 0.0035 17.2 2.7 0.0052 16.6 2.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CCF44758.1 - 0.0037 17.3 1.0 0.0037 17.3 1.0 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_4 PF14570.6 CCF44758.1 - 0.019 14.8 6.6 0.031 14.1 6.6 1.3 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Prok-RING_4 PF14447.6 CCF44758.1 - 0.22 11.4 4.7 0.45 10.4 4.7 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 PHD PF00628.29 CCF44758.1 - 0.25 11.3 5.8 0.43 10.5 5.8 1.4 1 0 0 1 1 1 0 PHD-finger FANCL_C PF11793.8 CCF44758.1 - 0.46 10.7 3.2 1.2 9.4 3.2 1.7 1 1 0 1 1 1 0 FANCL C-terminal domain Zn_ribbon_17 PF17120.5 CCF44758.1 - 0.63 9.7 4.8 1.1 9.0 4.8 1.3 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type OAD_gamma PF04277.13 CCF44758.1 - 1 10.0 0.0 1 10.0 0.0 3.3 2 1 0 2 2 1 0 Oxaloacetate decarboxylase, gamma chain zf-C3HC4_4 PF15227.6 CCF44758.1 - 1.1 9.4 4.7 2.3 8.4 4.7 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-UDP PF14569.6 CCF44758.1 - 1.8 8.7 4.5 0.74 10.0 0.6 2.3 2 0 0 2 2 2 0 Zinc-binding RING-finger Plasmodium_Vir PF05795.11 CCF44758.1 - 4.9 6.5 5.8 1 8.7 2.0 1.7 2 0 0 2 2 2 0 Plasmodium vivax Vir protein K_oxygenase PF13434.6 CCF44760.1 - 3.8e-05 23.0 0.6 0.0036 16.5 0.1 2.2 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 CCF44760.1 - 6.2e-05 22.4 0.0 0.095 11.9 0.0 2.9 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase 2-Hacid_dh_C PF02826.19 CCF44760.1 - 0.0017 17.7 0.0 0.0031 16.9 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 CCF44760.1 - 0.004 17.2 0.0 0.012 15.6 0.0 1.8 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase STAC2_u1 PF16664.5 CCF44760.1 - 0.03 14.8 1.4 0.057 13.9 1.4 1.4 1 0 0 1 1 1 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 FMO-like PF00743.19 CCF44760.1 - 0.03 12.7 0.1 0.25 9.7 0.0 2.0 2 0 0 2 2 2 0 Flavin-binding monooxygenase-like RasGAP PF00616.19 CCF44762.1 - 7.7e-36 123.8 0.5 1.8e-22 80.1 0.0 2.2 1 1 1 2 2 2 2 GTPase-activator protein for Ras-like GTPase CAP PF00188.26 CCF44763.1 - 3.5e-07 31.1 2.7 4e-07 30.9 2.7 1.1 1 0 0 1 1 1 1 Cysteine-rich secretory protein family TPR_12 PF13424.6 CCF44764.1 - 0.018 15.4 7.3 0.7 10.2 0.0 4.7 4 1 0 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.28 CCF44764.1 - 0.084 12.7 0.3 1.5 8.7 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 CCF44764.1 - 0.097 12.8 5.5 1.3 9.3 0.0 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_10 PF13374.6 CCF44764.1 - 0.15 12.0 0.6 31 4.6 0.1 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 CCF44764.1 - 0.19 12.6 8.6 36 5.6 0.5 5.2 3 2 2 5 5 5 0 Tetratricopeptide repeat DUF713 PF05218.14 CCF44766.1 - 0.038 13.7 0.5 0.056 13.2 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF713) Zn_clus PF00172.18 CCF44767.1 - 0.0074 16.4 8.2 0.015 15.4 8.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SPX PF03105.19 CCF44768.1 - 5.2e-09 36.5 14.4 0.00022 21.2 0.0 4.0 2 1 2 4 4 4 3 SPX domain DUF998 PF06197.13 CCF44768.1 - 0.013 15.2 3.5 0.02 14.5 3.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF998) Prefoldin_3 PF13758.6 CCF44768.1 - 0.22 11.6 2.6 0.39 10.8 0.6 2.4 3 1 0 3 3 3 0 Prefoldin subunit DNApol_Exo PF18136.1 CCF44769.1 - 4.3e-47 160.6 0.0 7e-47 159.9 0.0 1.3 1 0 0 1 1 1 1 DNA mitochondrial polymerase exonuclease domain Epimerase PF01370.21 CCF44771.1 - 2.9e-06 27.0 0.0 0.0034 16.9 0.0 2.1 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 CCF44771.1 - 0.1 12.9 0.0 0.16 12.2 0.0 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain NAD_binding_4 PF07993.12 CCF44771.1 - 0.13 11.4 0.0 0.78 8.9 0.1 1.9 2 0 0 2 2 2 0 Male sterility protein SH3_9 PF14604.6 CCF44772.1 - 1.5e-10 40.7 0.0 2.3e-10 40.2 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 CCF44772.1 - 2.8e-06 26.8 0.0 3.9e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 CCF44772.1 - 5.8e-05 22.7 0.0 9.5e-05 22.0 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain Peptidase_M24 PF00557.24 CCF44774.1 - 1e-48 165.8 0.0 1.2e-48 165.6 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 zf-C6H2 PF15801.5 CCF44774.1 - 1.3e-20 73.4 6.8 1.3e-20 73.4 6.8 1.8 2 0 0 2 2 2 1 zf-MYND-like zinc finger, mRNA-binding zf-MYND PF01753.18 CCF44774.1 - 0.00049 20.1 3.6 0.00049 20.1 3.6 2.0 2 0 0 2 2 2 1 MYND finger DDE_1 PF03184.19 CCF44775.1 - 3.2e-13 49.7 0.0 6.6e-13 48.7 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 CCF44775.1 - 3.3e-08 33.4 0.0 8.6e-08 32.1 0.0 1.7 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 CCF44775.1 - 0.16 11.7 0.0 0.27 11.0 0.0 1.4 1 0 0 1 1 1 0 helix-turn-helix, Psq domain Pkinase PF00069.25 CCF44778.1 - 3.3e-33 115.2 0.0 3.7e-33 115.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF44778.1 - 1e-18 67.5 0.1 7.6e-18 64.7 0.1 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF44778.1 - 0.0001 21.8 0.0 0.00012 21.6 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 CCF44778.1 - 0.0029 16.5 2.9 0.0081 15.0 0.2 2.0 1 1 0 2 2 2 1 Fungal protein kinase APH PF01636.23 CCF44778.1 - 0.0055 16.7 0.0 0.053 13.4 0.1 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 CCF44778.1 - 0.0083 15.5 0.0 0.011 15.1 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 CCF44778.1 - 0.15 11.6 0.0 0.23 11.0 0.0 1.2 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Choline_kinase PF01633.20 CCF44778.1 - 0.16 11.5 0.0 0.24 11.0 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase RIO1 PF01163.22 CCF44778.1 - 0.22 11.1 0.0 0.32 10.6 0.0 1.3 1 1 0 1 1 1 0 RIO1 family Pox_ser-thr_kin PF05445.11 CCF44778.1 - 0.25 10.3 0.0 0.38 9.7 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Cwf_Cwc_15 PF04889.12 CCF44779.1 - 0.00086 19.1 2.0 0.0009 19.0 2.0 1.0 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein TBCC_N PF16752.5 CCF44779.1 - 0.0097 16.3 0.7 0.011 16.1 0.7 1.1 1 0 0 1 1 1 1 Tubulin-specific chaperone C N-terminal domain Kelch_4 PF13418.6 CCF44782.1 - 2.7e-35 120.1 7.0 5.2e-08 32.8 0.5 6.4 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_1 PF01344.25 CCF44782.1 - 2.7e-30 103.7 5.4 6.4e-14 51.3 0.2 6.6 6 0 0 6 6 6 5 Kelch motif Kelch_5 PF13854.6 CCF44782.1 - 4e-27 93.7 12.4 6.2e-08 32.4 0.2 6.9 7 0 0 7 7 7 5 Kelch motif Kelch_3 PF13415.6 CCF44782.1 - 2e-26 91.7 7.5 1.2e-07 31.9 0.1 6.1 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_6 PF13964.6 CCF44782.1 - 4.9e-26 90.1 6.8 1.3e-10 41.2 0.5 6.5 5 1 1 6 6 6 6 Kelch motif Kelch_2 PF07646.15 CCF44782.1 - 3.7e-20 71.1 8.3 1.6e-07 31.0 0.2 6.6 6 0 0 6 6 6 5 Kelch motif Filament PF00038.21 CCF44782.1 - 0.0045 16.6 32.9 0.0045 16.6 32.9 3.8 2 1 1 4 4 4 1 Intermediate filament protein Serglycin PF04360.12 CCF44782.1 - 0.51 10.3 4.6 0.59 10.1 2.9 2.0 2 0 0 2 2 2 0 Serglycin Git3 PF11710.8 CCF44783.1 - 0.00026 20.8 0.0 0.00054 19.8 0.0 1.5 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 OapA_N PF08525.11 CCF44783.1 - 0.077 13.0 0.1 0.16 12.0 0.1 1.5 1 0 0 1 1 1 0 Opacity-associated protein A N-terminal motif WD40 PF00400.32 CCF44784.1 - 3.7e-18 65.5 0.1 7.7e-06 26.6 0.2 5.3 5 1 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF44784.1 - 2.8e-06 27.5 0.6 0.0016 18.7 0.1 3.8 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain P34-Arc PF04045.14 CCF44785.1 - 4.3e-71 239.4 0.0 5.7e-71 239.0 0.0 1.1 1 0 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc DUF4178 PF13785.6 CCF44785.1 - 0.09 12.9 0.1 0.15 12.2 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4178) Metallophos PF00149.28 CCF44786.1 - 5.3e-05 23.8 0.0 7.8e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase TERT_thumb PF17984.1 CCF44786.1 - 0.17 11.8 0.1 0.22 11.4 0.1 1.1 1 0 0 1 1 1 0 Telomerase reverse transcriptase thumb DNA binding domain Glyco_hydro_53 PF07745.13 CCF44787.1 - 5.6e-51 173.5 0.0 5.4e-43 147.3 0.0 2.0 1 1 1 2 2 2 2 Glycosyl hydrolase family 53 Aminotran_1_2 PF00155.21 CCF44788.1 - 4.8e-35 121.4 0.0 5.8e-35 121.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II VWA PF00092.28 CCF44789.1 - 2.6e-05 24.6 0.0 0.00011 22.5 0.0 1.9 1 1 0 1 1 1 1 von Willebrand factor type A domain vWA-TerF-like PF10138.9 CCF44789.1 - 0.00043 20.4 0.0 0.00079 19.6 0.0 1.4 1 1 0 1 1 1 1 vWA found in TerF C terminus VWA_2 PF13519.6 CCF44789.1 - 0.019 15.6 0.0 0.054 14.2 0.0 1.8 1 1 0 1 1 1 0 von Willebrand factor type A domain RTC4 PF14474.6 CCF44789.1 - 0.21 11.8 0.4 0.51 10.5 0.0 1.7 2 0 0 2 2 2 0 RTC4-like domain bZIP_2 PF07716.15 CCF44791.1 - 2.1e-12 46.9 12.2 3.3e-12 46.3 12.2 1.3 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 CCF44791.1 - 0.021 14.9 11.4 0.021 14.9 11.4 1.7 1 1 1 2 2 2 0 bZIP transcription factor TssO PF17561.2 CCF44791.1 - 0.043 13.9 2.9 0.058 13.5 2.9 1.1 1 0 0 1 1 1 0 Type VI secretion system, TssO bZIP_Maf PF03131.17 CCF44791.1 - 0.062 13.8 6.8 0.12 12.9 6.8 1.5 1 0 0 1 1 1 0 bZIP Maf transcription factor TSC22 PF01166.18 CCF44791.1 - 0.064 13.6 0.7 0.14 12.5 0.7 1.6 1 1 0 1 1 1 0 TSC-22/dip/bun family LCD1 PF09798.9 CCF44791.1 - 0.22 10.0 5.4 0.21 10.1 5.4 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein XhlA PF10779.9 CCF44791.1 - 0.29 11.4 2.9 0.57 10.4 2.9 1.4 1 0 0 1 1 1 0 Haemolysin XhlA FapA PF03961.13 CCF44791.1 - 0.42 9.2 4.9 0.49 8.9 4.9 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A U1snRNP70_N PF12220.8 CCF44791.1 - 2.6 8.7 11.5 1.9 9.2 7.6 2.4 2 1 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal YabA PF06156.13 CCF44791.1 - 4.2 8.1 7.3 2.7 8.7 4.7 1.8 1 1 1 2 2 2 0 Initiation control protein YabA ApoLp-III PF07464.11 CCF44794.1 - 0.12 12.4 7.0 0.58 10.2 5.8 2.5 1 1 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) CdvA PF18822.1 CCF44794.1 - 0.25 11.2 16.8 1.8 8.4 2.0 3.4 1 1 2 3 3 3 0 CdvA-like coiled-coil domain Baculo_PEP_C PF04513.12 CCF44794.1 - 0.33 11.0 2.3 1.7 8.7 1.7 2.1 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Rab5-bind PF09311.11 CCF44794.1 - 0.53 9.6 14.6 0.1 12.0 8.1 2.2 1 1 1 2 2 2 0 Rabaptin-like protein MRP-S31 PF15433.6 CCF44794.1 - 0.62 9.7 11.5 0.069 12.8 7.0 1.7 2 0 0 2 2 2 0 Mitochondrial 28S ribosomal protein S31 Lge1 PF11488.8 CCF44794.1 - 0.74 10.0 5.2 2 8.6 0.7 2.8 2 0 0 2 2 2 0 Transcriptional regulatory protein LGE1 DUF1451 PF07295.11 CCF44794.1 - 1.5 8.9 7.4 0.28 11.2 3.0 1.9 1 1 1 2 2 2 0 Zinc-ribbon containing domain Apolipoprotein PF01442.18 CCF44794.1 - 1.6 8.6 15.0 3.8 7.3 15.0 1.6 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain ECH_2 PF16113.5 CCF44794.1 - 1.6 8.2 5.6 1.4 8.3 3.8 1.8 2 1 0 2 2 2 0 Enoyl-CoA hydratase/isomerase Prominin PF05478.11 CCF44794.1 - 1.7 6.5 3.4 2.9 5.8 3.4 1.3 1 0 0 1 1 1 0 Prominin ING PF12998.7 CCF44794.1 - 1.7 9.2 7.8 4.9 7.8 0.9 3.0 2 1 1 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding DUF4709 PF15821.5 CCF44794.1 - 3.5 7.9 6.4 3.5 8.0 1.1 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4709) T4SS PF07996.11 CCF44794.1 - 3.7 7.9 10.4 4.6 7.6 1.1 3.2 2 1 1 3 3 3 0 Type IV secretion system proteins MPS2 PF17060.5 CCF44794.1 - 4.1 6.6 10.7 13 4.9 9.0 2.2 2 0 0 2 2 2 0 Monopolar spindle protein 2 HALZ PF02183.18 CCF44794.1 - 9.9 6.5 7.3 1.9 8.8 0.6 3.2 3 1 0 3 3 3 0 Homeobox associated leucine zipper zf-C2H2_jaz PF12171.8 CCF44795.1 - 5.3e-07 29.8 0.2 8.9e-07 29.0 0.2 1.4 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CCF44795.1 - 3.8e-05 23.9 0.1 6.4e-05 23.2 0.1 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type SNRNP27 PF08648.12 CCF44795.1 - 0.0072 16.4 0.4 0.024 14.7 0.4 2.0 1 0 0 1 1 1 1 U4/U6.U5 small nuclear ribonucleoproteins zf-DBF PF07535.12 CCF44795.1 - 0.0096 16.0 0.1 0.019 15.1 0.1 1.4 1 0 0 1 1 1 1 DBF zinc finger zf-C2H2 PF00096.26 CCF44795.1 - 0.024 15.1 0.5 0.041 14.3 0.5 1.4 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_2 PF12756.7 CCF44795.1 - 0.048 14.0 0.0 0.094 13.1 0.0 1.4 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 CCF44795.1 - 0.15 13.0 0.1 0.28 12.1 0.1 1.4 1 0 0 1 1 1 0 C2H2-type zinc finger DUF4586 PF15239.6 CCF44795.1 - 3.2 7.9 8.3 0.046 13.9 0.6 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4586) UQ_con PF00179.26 CCF44796.1 - 7.4e-35 119.6 0.0 8.4e-35 119.5 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 CCF44796.1 - 0.00043 20.0 0.0 0.00072 19.3 0.0 1.4 1 1 0 1 1 1 1 Prokaryotic E2 family B TRP PF06011.12 CCF44797.1 - 1.3e-130 435.9 19.5 1.7e-130 435.6 19.5 1.1 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 CCF44797.1 - 6.1e-39 133.6 3.1 6.1e-39 133.6 3.1 1.7 2 0 0 2 2 2 1 ML-like domain Methyltransf_23 PF13489.6 CCF44798.1 - 0.0028 17.5 0.0 0.0038 17.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CCF44798.1 - 0.11 12.0 0.0 0.15 11.6 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain ADH_zinc_N PF00107.26 CCF44799.1 - 5.7e-24 84.6 0.4 7.2e-24 84.2 0.4 1.1 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCF44799.1 - 4.9e-06 27.6 0.1 6.6e-06 27.2 0.1 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase DUF359 PF04019.12 CCF44799.1 - 0.017 14.7 0.0 0.026 14.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF359) CoA_binding PF02629.19 CCF44799.1 - 1.2 9.9 3.8 1.3 9.8 0.9 2.4 3 1 0 3 3 3 0 CoA binding domain UBA PF00627.31 CCF44800.1 - 1.4e-14 53.6 0.5 2.8e-14 52.7 0.5 1.5 1 0 0 1 1 1 1 UBA/TS-N domain XPC-binding PF09280.11 CCF44800.1 - 8.1e-09 35.1 1.0 1.3e-08 34.4 1.0 1.4 1 0 0 1 1 1 1 XPC-binding domain eIF-5a PF01287.20 CCF44800.1 - 0.09 12.9 0.0 0.14 12.2 0.0 1.3 1 0 0 1 1 1 0 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold DUF3113 PF11310.8 CCF44800.1 - 0.11 12.4 0.9 8.1 6.5 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3113) Myb_DNA-bind_7 PF15963.5 CCF44801.1 - 7.5e-25 86.7 1.3 1e-24 86.2 0.3 1.8 2 0 0 2 2 2 1 Myb DNA-binding like Myb_DNA-binding PF00249.31 CCF44801.1 - 8.2e-07 29.1 0.0 1.7e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CCF44801.1 - 0.0029 17.8 0.0 0.0086 16.3 0.0 1.9 1 1 1 2 2 2 1 Myb-like DNA-binding domain MARVEL PF01284.23 CCF44802.1 - 0.62 10.1 17.1 6 6.9 17.1 2.2 1 1 0 1 1 1 0 Membrane-associating domain Zn_clus PF00172.18 CCF44803.1 - 4.9e-09 36.2 9.5 7.7e-09 35.5 9.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CCF44803.1 - 7.8e-05 21.8 0.0 0.00024 20.2 0.0 1.8 1 1 0 1 1 1 1 Fungal specific transcription factor domain RrnaAD PF00398.20 CCF44804.1 - 4.1e-57 193.3 0.0 5.5e-57 192.8 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 CCF44804.1 - 3.9e-06 27.5 0.0 7.8e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 CCF44804.1 - 0.00015 21.6 0.0 0.00023 21.0 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.20 CCF44804.1 - 0.00046 19.6 0.0 0.0007 19.0 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_11 PF08241.12 CCF44804.1 - 0.0031 18.1 0.0 0.0074 16.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF44804.1 - 0.0039 17.9 0.0 0.01 16.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF44804.1 - 0.01 15.6 0.0 0.017 15.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 CCF44804.1 - 0.021 14.6 0.0 0.035 13.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_4 PF02390.17 CCF44804.1 - 0.029 13.8 0.0 0.07 12.6 0.0 1.6 1 0 0 1 1 1 0 Putative methyltransferase NodS PF05401.11 CCF44804.1 - 0.031 13.9 0.0 0.34 10.5 0.0 2.1 2 0 0 2 2 2 0 Nodulation protein S (NodS) MTS PF05175.14 CCF44804.1 - 0.042 13.4 0.0 0.073 12.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_28 PF02636.17 CCF44804.1 - 0.047 13.3 0.0 0.13 11.8 0.0 1.8 2 0 0 2 2 2 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Ubie_methyltran PF01209.18 CCF44804.1 - 0.051 12.9 0.0 0.088 12.1 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family AAA_lid_4 PF17864.1 CCF44804.1 - 0.063 13.0 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 RuvB AAA lid domain Cwf_Cwc_15 PF04889.12 CCF44804.1 - 0.23 11.1 6.3 0.32 10.7 6.3 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DNA_pol_phi PF04931.13 CCF44804.1 - 3.6 5.6 8.1 5 5.1 8.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi PUF PF00806.19 CCF44806.1 - 8.2e-26 88.2 0.0 3.9e-05 23.1 0.0 5.6 5 0 0 5 5 5 5 Pumilio-family RNA binding repeat RRM_1 PF00076.22 CCF44806.1 - 3.7e-13 49.1 0.0 8.1e-13 48.0 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HAD_2 PF13419.6 CCF44807.1 - 8e-10 39.1 0.0 1.7e-09 38.0 0.0 1.5 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CCF44807.1 - 0.0013 19.0 0.0 0.013 15.8 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase cEGF PF12662.7 CCF44809.1 - 0.11 12.4 0.2 0.11 12.4 0.2 1.9 2 1 0 2 2 2 0 Complement Clr-like EGF-like PEMT PF04191.13 CCF44810.1 - 5.6e-49 164.9 10.2 7.7e-27 93.8 1.7 2.7 2 0 0 2 2 2 2 Phospholipid methyltransferase CopD PF05425.13 CCF44810.1 - 0.019 15.3 0.7 0.019 15.3 0.7 2.4 2 0 0 2 2 2 0 Copper resistance protein D Amino_oxidase PF01593.24 CCF44811.1 - 0.027 13.8 0.1 1.9 7.7 0.0 2.1 1 1 0 2 2 2 0 Flavin containing amine oxidoreductase DUF5538 PF17692.1 CCF44812.1 - 0.32 11.0 4.0 0.37 10.8 4.0 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5538) OPT PF03169.15 CCF44813.1 - 6e-21 74.7 7.6 6.9e-21 74.5 7.6 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein MFS_1 PF07690.16 CCF44814.1 - 0.063 12.2 0.0 0.074 12.0 0.0 1.1 1 0 0 1 1 1 0 Major Facilitator Superfamily DDE_1 PF03184.19 CCF44815.1 - 6.8e-20 71.4 0.0 1.7e-19 70.1 0.0 1.7 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 CCF44815.1 - 1.9e-11 43.8 0.2 8.4e-11 41.7 0.0 2.0 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 CCF44815.1 - 9e-07 28.5 0.0 1.6e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 helix-turn-helix, Psq domain MFS_1 PF07690.16 CCF44816.1 - 1e-34 120.0 26.4 7e-34 117.3 26.1 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 CCF44816.1 - 1.7e-16 59.8 8.1 2e-16 59.5 8.1 1.0 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 CCF44816.1 - 6.6e-09 35.1 14.9 6.6e-09 35.1 14.9 1.7 2 0 0 2 2 2 1 Sugar (and other) transporter GPHR_N PF12537.8 CCF44816.1 - 0.06 13.4 1.6 0.18 11.9 0.0 2.3 2 0 0 2 2 2 0 The Golgi pH Regulator (GPHR) Family N-terminal OATP PF03137.20 CCF44816.1 - 0.29 9.4 7.3 0.28 9.4 5.9 1.6 1 1 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family UQ_con PF00179.26 CCF44818.1 - 1.1e-20 73.7 0.0 1.6e-20 73.2 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 CCF44818.1 - 0.022 14.5 0.0 0.035 13.8 0.0 1.4 1 0 0 1 1 1 0 Prokaryotic E2 family B MFS_1 PF07690.16 CCF44819.1 - 2.6e-24 85.8 33.1 2.6e-24 85.8 33.1 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF44819.1 - 5.3e-10 38.7 8.3 5.3e-10 38.7 8.3 2.8 2 1 0 2 2 2 1 Sugar (and other) transporter HET PF06985.11 CCF44820.1 - 3e-27 95.8 0.0 4.7e-27 95.1 0.0 1.3 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Aldo_ket_red PF00248.21 CCF44821.1 - 2.6e-41 141.7 0.1 4.9e-32 111.3 0.0 2.0 2 0 0 2 2 2 2 Aldo/keto reductase family DUF2110 PF09883.9 CCF44821.1 - 0.036 13.7 0.0 1 8.9 0.0 2.5 2 1 1 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2110) BPL_LplA_LipB PF03099.19 CCF44821.1 - 0.073 13.0 0.0 0.2 11.5 0.0 1.7 1 0 0 1 1 1 0 Biotin/lipoate A/B protein ligase family Zn_clus PF00172.18 CCF44823.1 - 5.4e-09 36.0 13.6 8.1e-09 35.5 13.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RF-1 PF00472.20 CCF44824.1 - 6.1e-11 42.3 0.0 9.6e-11 41.6 0.0 1.2 1 0 0 1 1 1 1 RF-1 domain MFS_1 PF07690.16 CCF44826.1 - 7.9e-20 71.1 13.4 1.1e-19 70.6 13.4 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 CCF44826.1 - 0.024 13.0 0.3 0.034 12.6 0.3 1.1 1 0 0 1 1 1 0 Fungal trichothecene efflux pump (TRI12) DUF1523 PF07509.11 CCF44826.1 - 0.033 13.6 0.0 0.061 12.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1523) TPPK_C PF12555.8 CCF44826.1 - 0.19 11.8 2.5 0.2 11.7 0.1 2.3 2 0 0 2 2 2 0 Thiamine pyrophosphokinase C terminal Fungal_trans PF04082.18 CCF44827.1 - 1e-16 60.8 0.0 1.9e-16 59.9 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF44827.1 - 5.2e-09 36.1 9.7 1e-08 35.1 9.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF5079 PF16882.5 CCF44827.1 - 0.026 14.4 0.0 7.2 6.4 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5079) YqjK PF13997.6 CCF44827.1 - 0.041 14.1 0.8 10 6.4 0.5 2.9 2 0 0 2 2 2 0 YqjK-like protein DIE2_ALG10 PF04922.12 CCF44828.1 - 2.4e-116 389.3 0.0 3.9e-115 385.3 0.0 2.1 1 1 0 1 1 1 1 DIE2/ALG10 family Pkinase PF00069.25 CCF44829.1 - 5.9e-15 55.3 0.0 3.1e-14 53.0 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF44829.1 - 4e-09 36.2 0.0 6.7e-08 32.1 0.0 2.3 1 1 0 1 1 1 1 Protein tyrosine kinase DCB PF16213.5 CCF44829.1 - 0.092 12.4 1.1 0.16 11.6 0.1 1.9 2 0 0 2 2 2 0 Dimerisation and cyclophilin-binding domain of Mon2 Aminotran_4 PF01063.19 CCF44830.1 - 1.8e-33 116.3 0.0 2.3e-33 115.9 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV ESSS PF10183.9 CCF44831.1 - 5.9e-11 42.5 0.0 7.5e-11 42.2 0.0 1.3 1 1 0 1 1 1 1 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) AAA_12 PF13087.6 CCF44832.1 - 2.4e-52 177.4 0.0 4.7e-52 176.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 CCF44832.1 - 1.5e-34 120.0 1.7 7.3e-18 65.3 0.0 3.0 2 1 1 3 3 3 2 AAA domain AAA_30 PF13604.6 CCF44832.1 - 3.2e-14 53.1 0.0 7.9e-14 51.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CCF44832.1 - 6.3e-13 49.3 0.2 2.2e-12 47.6 0.0 2.1 2 0 0 2 2 1 1 AAA domain Dna2 PF08696.11 CCF44832.1 - 3.6e-11 43.3 2.2 9.7e-11 41.9 0.0 2.6 2 1 0 2 2 2 1 DNA replication factor Dna2 Viral_helicase1 PF01443.18 CCF44832.1 - 3.2e-08 33.6 0.3 0.15 11.8 0.0 3.4 3 0 0 3 3 3 3 Viral (Superfamily 1) RNA helicase Cas_Cas4 PF01930.17 CCF44832.1 - 3.6e-08 33.7 0.2 7.1e-08 32.7 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function DUF83 Helicase_RecD PF05127.14 CCF44832.1 - 6.2e-05 22.9 0.0 0.00022 21.1 0.0 1.9 1 1 0 1 1 1 1 Helicase UvrD-helicase PF00580.21 CCF44832.1 - 0.00038 20.1 0.2 0.00094 18.8 0.0 1.8 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain PIF1 PF05970.14 CCF44832.1 - 0.00059 19.1 0.1 0.0046 16.2 0.1 2.0 1 1 0 1 1 1 1 PIF1-like helicase SRP54 PF00448.22 CCF44832.1 - 0.00072 19.2 0.1 0.0015 18.2 0.1 1.5 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_16 PF13191.6 CCF44832.1 - 0.0023 18.3 0.0 0.0056 17.1 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain CbiA PF01656.23 CCF44832.1 - 0.0039 17.3 0.1 0.0082 16.2 0.1 1.6 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MobB PF03205.14 CCF44832.1 - 0.015 15.2 0.1 0.31 10.9 0.0 2.7 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_7 PF12775.7 CCF44832.1 - 0.019 14.5 0.0 0.045 13.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF87 PF01935.17 CCF44832.1 - 0.03 14.4 0.2 0.062 13.4 0.2 1.4 1 0 0 1 1 1 0 Helicase HerA, central domain ResIII PF04851.15 CCF44832.1 - 0.031 14.3 0.0 0.1 12.6 0.0 1.9 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit NTPase_1 PF03266.15 CCF44832.1 - 0.031 14.2 0.1 0.13 12.2 0.2 1.9 2 0 0 2 2 1 0 NTPase cobW PF02492.19 CCF44832.1 - 0.036 13.7 0.1 0.11 12.1 0.0 1.7 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain DUF2075 PF09848.9 CCF44832.1 - 0.039 13.2 0.1 0.11 11.7 0.1 1.9 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_25 PF13481.6 CCF44832.1 - 0.043 13.4 0.0 0.23 11.0 0.0 2.2 3 0 0 3 3 2 0 AAA domain FtsK_SpoIIIE PF01580.18 CCF44832.1 - 0.051 12.9 0.0 0.78 9.1 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family TrwB_AAD_bind PF10412.9 CCF44832.1 - 0.062 12.2 0.1 0.47 9.3 0.1 2.1 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain MeaB PF03308.16 CCF44832.1 - 0.064 12.2 0.4 0.17 10.9 0.0 1.8 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_18 PF13238.6 CCF44832.1 - 0.091 13.3 0.0 0.26 11.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 CCF44832.1 - 0.097 12.7 0.1 0.4 10.7 0.1 2.0 2 0 0 2 2 1 0 AAA domain (dynein-related subfamily) AAA PF00004.29 CCF44832.1 - 0.1 13.0 0.1 0.23 11.9 0.1 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 CCF44832.1 - 0.14 11.9 0.0 0.27 11.0 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain PEPCK_ATP PF01293.20 CCF44832.1 - 0.15 10.7 0.0 0.25 10.0 0.0 1.2 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxykinase CAS_CSE1 PF03378.15 CCF44834.1 - 6.5e-165 548.9 0.2 7.3e-165 548.8 0.2 1.0 1 0 0 1 1 1 1 CAS/CSE protein, C-terminus UME PF08064.13 CCF44834.1 - 0.0014 18.5 0.1 0.13 12.2 0.0 2.7 2 1 0 2 2 2 2 UME (NUC010) domain CBFD_NFYB_HMF PF00808.23 CCF44835.1 - 5.2e-05 23.4 0.1 6.6e-05 23.1 0.1 1.1 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-W PF15510.6 CCF44835.1 - 0.00018 21.7 0.0 0.00019 21.6 0.0 1.1 1 0 0 1 1 1 1 CENP-W protein TAFII28 PF04719.14 CCF44835.1 - 0.11 12.6 0.3 0.16 12.1 0.3 1.3 1 1 0 1 1 1 0 hTAFII28-like protein conserved region Prefoldin_2 PF01920.20 CCF44836.1 - 4.9e-25 87.5 9.4 4.9e-25 87.5 9.4 1.4 2 0 0 2 2 2 1 Prefoldin subunit bZIP_1 PF00170.21 CCF44836.1 - 0.019 15.1 1.4 0.019 15.1 1.4 2.2 2 0 0 2 2 2 0 bZIP transcription factor PI3K_P85_iSH2 PF16454.5 CCF44836.1 - 0.022 14.3 7.4 0.049 13.2 7.4 1.5 1 1 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain UPF0242 PF06785.11 CCF44836.1 - 0.052 13.7 7.3 0.066 13.3 7.3 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Baculo_PEP_C PF04513.12 CCF44836.1 - 0.1 12.6 0.6 0.17 11.9 0.1 1.5 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Syntaxin-6_N PF09177.11 CCF44836.1 - 0.12 12.9 6.6 0.83 10.3 1.7 2.2 2 0 0 2 2 2 0 Syntaxin 6, N-terminal DUF1664 PF07889.12 CCF44836.1 - 0.4 10.7 0.1 0.4 10.7 0.1 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) Pectinesterase PF01095.19 CCF44837.1 - 6.5e-39 133.4 6.2 1e-38 132.8 6.2 1.2 1 0 0 1 1 1 1 Pectinesterase Pec_lyase_C PF00544.19 CCF44837.1 - 7.7e-13 48.5 5.7 1.1e-12 48.0 2.1 2.7 2 1 0 2 2 2 1 Pectate lyase Beta_helix PF13229.6 CCF44837.1 - 0.0057 16.5 1.1 0.0057 16.5 1.1 2.7 2 1 0 2 2 2 1 Right handed beta helix region MPP6 PF10175.9 CCF44837.1 - 0.13 12.8 3.3 0.25 11.9 3.3 1.4 1 0 0 1 1 1 0 M-phase phosphoprotein 6 Radial_spoke PF04712.12 CCF44837.1 - 4.5 6.1 8.9 6.4 5.6 8.9 1.1 1 0 0 1 1 1 0 Radial spokehead-like protein Ketoacyl-synt_C PF02801.22 CCF44838.1 - 1.3e-29 102.6 0.0 2.8e-29 101.5 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 CCF44838.1 - 1.2e-26 93.4 0.0 1.7e-26 92.8 0.0 1.3 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Acyl_transf_1 PF00698.21 CCF44838.1 - 1.6e-05 24.6 0.1 2.7e-05 23.8 0.1 1.3 1 0 0 1 1 1 1 Acyl transferase domain TLP1_add_C PF18313.1 CCF44838.1 - 0.024 14.6 0.0 0.046 13.7 0.0 1.5 1 0 0 1 1 1 0 Thiolase-like protein type 1 additional C-terminal domain ADH_N PF08240.12 CCF44839.1 - 0.00011 22.0 0.0 0.00015 21.6 0.0 1.1 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Castor_Poll_mid PF06241.12 CCF44839.1 - 0.11 12.4 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 Castor and Pollux, part of voltage-gated ion channel LigB PF02900.18 CCF44840.1 - 1.6e-35 122.5 0.0 2e-35 122.2 0.0 1.0 1 0 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase His_Phos_1 PF00300.22 CCF44843.1 - 1.2 8.8 6.1 13 5.5 0.0 3.0 3 0 0 3 3 3 0 Histidine phosphatase superfamily (branch 1) B-block_TFIIIC PF04182.12 CCF44844.1 - 5.8e-13 48.8 0.0 1.1e-12 47.9 0.0 1.5 1 0 0 1 1 1 1 B-block binding subunit of TFIIIC zf-TFIIB PF13453.6 CCF44844.1 - 0.032 13.6 0.0 0.071 12.5 0.0 1.5 1 0 0 1 1 1 0 Transcription factor zinc-finger Elf1 PF05129.13 CCF44844.1 - 0.18 11.8 1.7 0.42 10.7 1.7 1.6 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like Fungal_trans PF04082.18 CCF44846.1 - 7.6e-26 90.7 0.5 7.6e-26 90.7 0.5 2.0 2 0 0 2 2 2 1 Fungal specific transcription factor domain EPL1 PF10513.9 CCF44846.1 - 0.0096 16.3 3.5 0.016 15.6 3.5 1.3 1 0 0 1 1 1 1 Enhancer of polycomb-like TFIIA PF03153.13 CCF44846.1 - 0.024 14.6 16.6 0.038 14.0 16.6 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Med15 PF09606.10 CCF44846.1 - 0.24 10.1 17.5 0.32 9.6 17.5 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF4834 PF16118.5 CCF44846.1 - 0.38 11.7 5.6 0.89 10.6 5.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Suf PF05843.14 CCF44846.1 - 0.78 9.7 8.2 1.3 9.0 8.2 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Spt20 PF12090.8 CCF44846.1 - 2.1 7.9 25.2 3.5 7.2 25.2 1.2 1 0 0 1 1 1 0 Spt20 family Presenilin PF01080.17 CCF44846.1 - 5.4 5.7 8.4 8.7 5.0 8.4 1.2 1 0 0 1 1 1 0 Presenilin BBE PF08031.12 CCF44847.1 - 0.00052 20.1 0.2 0.00075 19.6 0.2 1.2 1 0 0 1 1 1 1 Berberine and berberine like Sterol-sensing PF12349.8 CCF44849.1 - 7.6e-13 48.6 5.8 5.1e-11 42.6 5.8 2.6 1 1 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.18 CCF44849.1 - 7.4e-06 24.3 0.8 1.1e-05 23.7 0.8 1.2 1 0 0 1 1 1 1 Patched family Lig_chan PF00060.26 CCF44849.1 - 0.0036 17.2 1.8 0.92 9.3 0.0 2.3 2 0 0 2 2 2 2 Ligand-gated ion channel Tetraspanin PF00335.20 CCF44849.1 - 4.3 7.0 6.3 0.52 10.0 1.1 2.0 1 1 1 2 2 2 0 Tetraspanin family MFS_1 PF07690.16 CCF44850.1 - 4.4e-45 154.1 34.6 7.7e-39 133.6 17.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF44850.1 - 8.2e-17 61.2 12.3 4.5e-16 58.8 12.3 1.8 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_4 PF06779.14 CCF44850.1 - 9.3e-07 28.5 12.6 0.00022 20.6 0.1 2.6 2 1 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB TRI12 PF06609.13 CCF44850.1 - 7.7e-06 24.6 0.2 7.7e-06 24.6 0.2 1.8 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Folate_carrier PF01770.18 CCF44850.1 - 1.2e-05 24.2 0.0 2e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Reduced folate carrier OATP PF03137.20 CCF44850.1 - 0.00051 18.5 5.9 0.00069 18.0 2.2 2.7 2 1 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family DUF5421 PF17458.2 CCF44850.1 - 0.063 12.7 1.8 0.093 12.1 1.8 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5421) DUF1980 PF09323.10 CCF44850.1 - 0.088 12.7 0.1 4 7.3 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) Fst_toxin PF13955.6 CCF44850.1 - 0.33 10.9 6.2 0.32 11.0 1.0 2.9 2 0 0 2 2 2 0 Toxin Fst, type I toxin-antitoxin system MerR-DNA-bind PF09278.11 CCF44853.1 - 0.54 10.8 10.5 0.87 10.2 10.5 1.4 1 0 0 1 1 1 0 MerR, DNA binding zf-C2H2_2 PF12756.7 CCF44855.1 - 2e-08 34.5 6.6 0.00039 20.7 0.9 2.5 1 1 1 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 CCF44855.1 - 1.8e-05 24.8 4.9 0.008 16.4 0.9 3.0 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 CCF44855.1 - 0.0027 18.1 4.6 0.046 14.2 0.4 3.0 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCF44855.1 - 0.0048 17.6 5.5 0.074 13.9 0.2 3.4 3 0 0 3 3 3 1 C2H2-type zinc finger LIM PF00412.22 CCF44855.1 - 0.028 14.6 1.9 1.1 9.6 0.2 3.0 2 0 0 2 2 2 0 LIM domain zf-met PF12874.7 CCF44855.1 - 0.049 14.0 8.1 0.19 12.2 0.4 3.1 3 0 0 3 3 3 0 Zinc-finger of C2H2 type Arc_trans_TRASH PF08394.10 CCF44855.1 - 0.21 11.9 6.2 3.3 8.1 1.0 2.6 2 0 0 2 2 2 0 Archaeal TRASH domain Evr1_Alr PF04777.13 CCF44855.1 - 0.66 10.5 3.7 9.7 6.7 0.2 2.5 1 1 1 2 2 2 0 Erv1 / Alr family NAD_kinase PF01513.21 CCF44857.1 - 3.3e-52 177.5 0.0 1e-51 175.9 0.0 1.6 1 1 0 1 1 1 1 ATP-NAD kinase ketoacyl-synt PF00109.26 CCF44858.1 - 8e-60 202.5 0.1 3.5e-59 200.4 0.0 2.1 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain PS-DH PF14765.6 CCF44858.1 - 6.7e-59 199.6 0.0 1.3e-58 198.6 0.0 1.5 1 0 0 1 1 1 1 Polyketide synthase dehydratase KR PF08659.10 CCF44858.1 - 7.6e-59 198.6 0.0 1.9e-58 197.3 0.0 1.8 1 0 0 1 1 1 1 KR domain Acyl_transf_1 PF00698.21 CCF44858.1 - 6.5e-58 196.7 0.1 1.1e-57 196.0 0.1 1.4 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 CCF44858.1 - 7.6e-31 106.6 0.3 7.6e-31 106.6 0.3 2.5 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 CCF44858.1 - 5.2e-21 75.2 0.0 1.4e-20 73.8 0.0 1.8 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension ADH_zinc_N_2 PF13602.6 CCF44858.1 - 6.9e-21 75.7 0.0 7.3e-19 69.1 0.0 3.1 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Methyltransf_12 PF08242.12 CCF44858.1 - 1.6e-19 70.4 0.0 4.2e-19 69.1 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain ADH_zinc_N PF00107.26 CCF44858.1 - 1.4e-15 57.4 0.1 6.9e-15 55.2 0.1 2.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Methyltransf_23 PF13489.6 CCF44858.1 - 1.6e-13 50.8 0.0 5.5e-13 49.1 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF44858.1 - 1.8e-09 38.1 0.0 6.3e-09 36.4 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF44858.1 - 8.3e-09 36.0 0.0 3.3e-08 34.1 0.0 2.2 1 0 0 1 1 1 1 Methyltransferase domain ADH_N PF08240.12 CCF44858.1 - 9.6e-09 35.1 0.1 4e-08 33.1 0.0 2.1 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain adh_short PF00106.25 CCF44858.1 - 1.6e-08 34.3 0.0 5e-08 32.6 0.0 1.9 1 0 0 1 1 1 1 short chain dehydrogenase Methyltransf_31 PF13847.6 CCF44858.1 - 1.7e-08 34.4 0.0 5.1e-08 32.9 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Thiolase_N PF00108.23 CCF44858.1 - 0.00018 20.9 1.3 0.00048 19.6 0.1 2.1 2 0 0 2 2 2 1 Thiolase, N-terminal domain Ubie_methyltran PF01209.18 CCF44858.1 - 0.0002 20.8 0.0 0.00044 19.7 0.0 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_16 PF10294.9 CCF44858.1 - 0.0071 16.1 0.0 0.018 14.8 0.0 1.6 1 0 0 1 1 1 1 Lysine methyltransferase PP-binding PF00550.25 CCF44858.1 - 0.0081 16.5 0.0 0.025 14.9 0.0 1.9 1 0 0 1 1 1 1 Phosphopantetheine attachment site DREV PF05219.12 CCF44858.1 - 0.033 13.3 0.0 0.063 12.4 0.0 1.4 1 0 0 1 1 1 0 DREV methyltransferase SAT PF16073.5 CCF44858.1 - 0.034 13.9 0.0 4 7.1 0.1 2.4 2 0 0 2 2 2 0 Starter unit:ACP transacylase in aflatoxin biosynthesis ACP_syn_III PF08545.10 CCF44858.1 - 0.039 13.8 0.6 0.1 12.4 0.6 1.7 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III DUF3328 PF11807.8 CCF44859.1 - 1.6e-17 64.1 1.1 1.9e-17 63.8 1.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) CLAMP PF14769.6 CCF44859.1 - 0.095 13.2 0.0 0.15 12.5 0.0 1.3 1 0 0 1 1 1 0 Flagellar C1a complex subunit C1a-32 Thioesterase PF00975.20 CCF44861.1 - 2.7e-10 40.8 0.0 4.1e-10 40.2 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_6 PF12697.7 CCF44861.1 - 1.2e-06 29.3 0.3 1.5e-06 29.0 0.3 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 CCF44861.1 - 0.0021 17.9 0.0 0.0028 17.5 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF2974 PF11187.8 CCF44861.1 - 0.21 11.1 0.0 0.34 10.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) DUF3328 PF11807.8 CCF44862.1 - 0.039 13.7 0.1 0.051 13.3 0.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF3328) MFS_1 PF07690.16 CCF44864.1 - 2.2e-10 40.0 20.8 2.6e-10 39.7 18.9 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF44864.1 - 5.2e-06 25.6 3.1 8.4e-06 24.9 3.1 1.4 1 0 0 1 1 1 1 Sugar (and other) transporter DUF5326 PF17260.2 CCF44864.1 - 0.053 13.7 1.1 0.21 11.7 1.1 2.0 1 0 0 1 1 1 0 Family of unknown function (DUF5326) GTP_EFTU PF00009.27 CCF44865.1 - 3e-66 222.7 0.3 3.5e-66 222.5 0.3 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 CCF44865.1 - 0.00011 22.3 1.1 0.00018 21.5 0.3 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase PduV-EutP PF10662.9 CCF44865.1 - 0.008 15.9 0.4 0.045 13.5 0.1 2.1 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation GatB_N PF02934.15 CCF44867.1 - 4.8e-100 334.5 0.0 5.9e-100 334.1 0.0 1.1 1 0 0 1 1 1 1 GatB/GatE catalytic domain Methyltransf_25 PF13649.6 CCF44870.1 - 1.3e-10 41.9 0.0 3.9e-10 40.3 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.13 CCF44870.1 - 2.9e-10 40.0 0.0 4.4e-10 39.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 CCF44870.1 - 7.5e-09 35.6 0.0 1.5e-08 34.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF44870.1 - 7.4e-08 32.9 0.0 3e-07 31.0 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_9 PF08003.11 CCF44870.1 - 2.9e-06 26.4 0.1 4.2e-06 25.9 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_23 PF13489.6 CCF44870.1 - 7.3e-05 22.7 0.0 0.00019 21.3 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.7 CCF44870.1 - 0.00012 22.0 0.1 0.0002 21.3 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF44870.1 - 0.001 19.8 0.0 0.0023 18.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 CCF44870.1 - 0.0044 16.3 0.0 0.0061 15.9 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase PRMT5 PF05185.16 CCF44870.1 - 0.0067 16.3 0.1 0.013 15.3 0.1 1.6 1 1 0 1 1 1 1 PRMT5 arginine-N-methyltransferase MTS PF05175.14 CCF44870.1 - 0.0094 15.5 0.0 0.014 14.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_32 PF13679.6 CCF44870.1 - 0.083 12.9 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltrans_SAM PF10672.9 CCF44870.1 - 0.15 11.2 0.1 0.25 10.5 0.1 1.2 1 0 0 1 1 1 0 S-adenosylmethionine-dependent methyltransferase Cons_hypoth95 PF03602.15 CCF44870.1 - 0.18 11.4 0.0 0.27 10.9 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 MTCP1 PF08991.10 CCF44871.1 - 3.3e-22 78.5 1.3 4e-22 78.2 1.3 1.1 1 0 0 1 1 1 1 Mature-T-Cell Proliferation I type Cmc1 PF08583.10 CCF44871.1 - 0.03 14.3 1.6 0.046 13.8 1.6 1.3 1 0 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like UvrD_C_2 PF13538.6 CCF44871.1 - 0.03 14.1 0.0 0.048 13.5 0.0 1.3 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain CHCH PF06747.13 CCF44871.1 - 0.044 13.9 2.2 0.066 13.4 2.2 1.3 1 0 0 1 1 1 0 CHCH domain Nup84_Nup100 PF04121.13 CCF44873.1 - 1.9e-38 132.1 1.8 2.6e-38 131.7 1.8 1.1 1 0 0 1 1 1 1 Nuclear pore protein 84 / 107 ANTH PF07651.16 CCF44873.1 - 0.016 14.2 0.1 0.022 13.7 0.1 1.2 1 0 0 1 1 1 0 ANTH domain tRNA-synt_2 PF00152.20 CCF44874.1 - 7e-10 38.5 0.0 7.1e-10 38.5 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) Glyco_hydro_3 PF00933.21 CCF44875.1 - 3.6e-22 79.2 0.0 4.3e-22 78.9 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain TMEM171 PF15471.6 CCF44877.1 - 0.11 11.4 0.6 0.24 10.3 0.6 1.5 1 0 0 1 1 1 0 Transmembrane protein family 171 Abhydrolase_9_N PF15420.6 CCF44877.1 - 0.11 12.5 5.3 0.22 11.5 5.3 1.4 1 0 0 1 1 1 0 Alpha/beta-hydrolase family N-terminus DUF4418 PF14387.6 CCF44877.1 - 5.8 7.2 10.8 1.8 8.8 3.7 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4418) GET2 PF08690.10 CCF44878.1 - 1.7 8.3 5.7 2.7 7.6 5.7 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 Helicase_C PF00271.31 CCF44879.1 - 7e-32 110.1 0.0 1e-31 109.6 0.0 1.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Helicase_C_2 PF13307.6 CCF44879.1 - 0.003 17.8 0.0 0.0046 17.1 0.0 1.3 1 0 0 1 1 1 1 Helicase C-terminal domain ERCC3_RAD25_C PF16203.5 CCF44879.1 - 0.012 14.8 0.1 0.015 14.5 0.1 1.1 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase UTP25 PF06862.12 CCF44879.1 - 0.023 13.5 0.0 0.029 13.1 0.0 1.1 1 0 0 1 1 1 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 Melibiase_2 PF16499.5 CCF44880.1 - 1.7e-21 76.6 0.7 2.8e-21 75.9 0.7 1.3 1 1 0 1 1 1 1 Alpha galactosidase A Melibiase PF02065.18 CCF44880.1 - 1e-06 27.9 0.0 1.1e-06 27.8 0.0 1.0 1 0 0 1 1 1 1 Melibiase Dak2 PF02734.17 CCF44881.1 - 6.9e-36 123.7 0.5 8.1e-36 123.5 0.5 1.0 1 0 0 1 1 1 1 DAK2 domain LSM PF01423.22 CCF44882.1 - 6.5e-18 64.2 0.1 9.1e-18 63.7 0.1 1.2 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 CCF44882.1 - 0.12 12.0 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 Hfq protein Alpha-amylase PF00128.24 CCF44884.1 - 1e-57 196.2 0.0 1.5e-57 195.7 0.0 1.1 1 0 0 1 1 1 1 Alpha amylase, catalytic domain DUF1966 PF09260.11 CCF44884.1 - 1.8e-19 69.8 0.0 2.9e-19 69.1 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1966) Glyco_hydro_70 PF02324.16 CCF44884.1 - 0.054 11.7 0.1 0.078 11.2 0.1 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 70 DUF4504 PF14953.6 CCF44884.1 - 0.16 11.3 0.0 0.26 10.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4504) Pyr_redox_2 PF07992.14 CCF44885.1 - 1.3e-07 31.2 0.0 0.00015 21.2 0.0 2.5 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCF44885.1 - 9.2e-07 29.0 0.0 2.7e-05 24.3 0.0 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FMO-like PF00743.19 CCF44885.1 - 5.6e-05 21.8 0.0 0.00034 19.2 0.0 1.9 2 0 0 2 2 2 1 Flavin-binding monooxygenase-like K_oxygenase PF13434.6 CCF44885.1 - 6.8e-05 22.2 0.0 0.00024 20.4 0.0 1.7 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 CCF44885.1 - 0.00014 21.9 0.1 0.1 12.6 0.0 3.1 3 0 0 3 3 3 1 FAD-NAD(P)-binding Shikimate_DH PF01488.20 CCF44885.1 - 0.0026 17.8 0.0 0.14 12.3 0.0 2.4 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase ThiF PF00899.21 CCF44885.1 - 0.0094 15.3 0.5 0.28 10.5 0.2 2.2 2 0 0 2 2 2 1 ThiF family Pyr_redox PF00070.27 CCF44885.1 - 0.013 16.1 0.0 2.5 8.7 0.0 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCF44885.1 - 0.018 14.3 0.1 3.1 7.0 0.0 3.4 3 1 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase 2-Hacid_dh_C PF02826.19 CCF44885.1 - 0.083 12.2 0.0 0.18 11.2 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FAD_binding_3 PF01494.19 CCF44885.1 - 0.18 11.0 0.3 1.5 8.0 0.1 2.3 2 0 0 2 2 2 0 FAD binding domain p450 PF00067.22 CCF44886.1 - 9.2e-54 182.9 0.0 1.2e-53 182.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 polyprenyl_synt PF00348.17 CCF44887.1 - 2.5e-47 161.1 0.0 4.3e-47 160.3 0.0 1.3 1 0 0 1 1 1 1 Polyprenyl synthetase Terpene_synth_C PF03936.16 CCF44887.1 - 8.8e-05 22.0 1.2 0.0047 16.3 1.4 2.2 2 0 0 2 2 2 2 Terpene synthase family, metal binding domain Sporozoite_P67 PF05642.11 CCF44887.1 - 0.24 9.5 2.6 0.33 9.0 2.6 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen MetallophosC PF16370.5 CCF44888.1 - 0.00037 20.8 0.2 0.00057 20.1 0.2 1.2 1 0 0 1 1 1 1 C terminal of Calcineurin-like phosphoesterase RRP36 PF06102.12 CCF44889.1 - 6.8e-57 192.0 29.0 6.8e-57 192.0 29.0 1.7 2 0 0 2 2 2 1 rRNA biogenesis protein RRP36 Sec16 PF12932.7 CCF44889.1 - 0.088 13.4 1.2 0.19 12.3 1.1 1.9 1 1 0 1 1 1 0 Vesicle coat trafficking protein Sec16 mid-region CAF1A PF12253.8 CCF44889.1 - 2.3 8.5 11.2 2.1 8.6 8.4 2.3 2 0 0 2 2 2 0 Chromatin assembly factor 1 subunit A NIF PF03031.18 CCF44890.1 - 4.4e-11 42.8 0.0 5e-11 42.6 0.0 1.1 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase DUF1363 PF07101.11 CCF44890.1 - 0.078 13.3 0.0 0.093 13.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1363) Myosin_head PF00063.21 CCF44891.1 - 1.7e-08 33.2 0.0 2.3e-08 32.8 0.0 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) TRAPP PF04051.16 CCF44893.1 - 2.3e-46 157.2 0.0 2.8e-46 156.9 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component PorB PF11565.8 CCF44893.1 - 0.089 13.2 0.0 0.15 12.4 0.0 1.3 1 0 0 1 1 1 0 Alpha helical Porin B Ldh_1_C PF02866.18 CCF44894.1 - 3.5e-13 49.8 0.0 4e-13 49.7 0.0 1.0 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain DUF1844 PF08899.11 CCF44894.1 - 0.19 12.0 0.1 0.44 10.9 0.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF1844) Myosin_head PF00063.21 CCF44896.1 - 6.3e-205 682.4 1.2 7.4e-205 682.1 1.2 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 CCF44896.1 - 8.5e-33 113.6 0.0 1.7e-32 112.6 0.0 1.5 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding IQ PF00612.27 CCF44896.1 - 0.0018 17.9 10.0 0.1 12.4 2.4 2.7 1 1 1 2 2 2 2 IQ calmodulin-binding motif Hpr_kinase_C PF07475.12 CCF44896.1 - 0.017 14.7 0.3 3.2 7.2 0.1 2.3 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain AAA_22 PF13401.6 CCF44896.1 - 0.023 15.0 0.0 0.073 13.3 0.0 1.9 1 0 0 1 1 1 0 AAA domain DUF4913 PF16259.5 CCF44896.1 - 0.066 13.3 0.9 0.19 11.8 0.9 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4913) NACHT PF05729.12 CCF44896.1 - 0.069 13.1 0.1 0.23 11.4 0.0 1.9 2 0 0 2 2 2 0 NACHT domain AAA_16 PF13191.6 CCF44896.1 - 0.1 13.0 0.0 0.35 11.3 0.0 1.9 1 0 0 1 1 1 0 AAA ATPase domain DUF4145 PF13643.6 CCF44896.1 - 0.13 12.4 0.0 1.8 8.7 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4145) ABC_tran PF00005.27 CCF44896.1 - 0.28 11.7 1.8 0.62 10.6 0.7 2.2 2 1 0 2 2 2 0 ABC transporter Sec7_N PF12783.7 CCF44899.1 - 3.6e-40 137.4 3.3 3.6e-40 137.4 3.3 1.7 2 0 0 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DCB PF16213.5 CCF44899.1 - 2e-22 79.7 0.3 3.4e-22 79.0 0.3 1.4 1 0 0 1 1 1 1 Dimerisation and cyclophilin-binding domain of Mon2 TSNAXIP1_N PF15739.5 CCF44899.1 - 0.56 10.6 2.5 1.3 9.5 0.0 2.6 3 0 0 3 3 3 0 Translin-associated factor X-interacting N-terminus 2-oxoacid_dh PF00198.23 CCF44900.1 - 2.1e-73 246.6 0.0 2.8e-73 246.2 0.0 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 CCF44900.1 - 8.4e-19 67.2 0.6 2.2e-18 65.8 0.6 1.8 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 CCF44900.1 - 2.6e-09 37.3 2.4 8.7e-09 35.6 2.4 1.9 1 0 0 1 1 1 1 e3 binding domain Ribosomal_60s PF00428.19 CCF44900.1 - 8.2 7.1 16.6 22 5.8 0.7 2.7 2 1 0 2 2 2 0 60s Acidic ribosomal protein CALM_bind PF16025.5 CCF44902.1 - 0.61 10.6 5.8 0.96 10.0 5.8 1.3 1 0 0 1 1 1 0 Calcium-dependent calmodulin binding UDPG_MGDP_dh_N PF03721.14 CCF44903.1 - 4.8e-30 104.5 0.0 7.3e-30 103.9 0.0 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Sacchrp_dh_NADP PF03435.18 CCF44903.1 - 0.00072 19.8 0.0 0.0012 19.0 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain 3HCDH_N PF02737.18 CCF44903.1 - 0.013 15.4 0.0 0.028 14.3 0.0 1.7 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 CCF44903.1 - 0.02 15.1 0.0 0.12 12.5 0.0 2.2 1 1 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Pyr_redox_2 PF07992.14 CCF44903.1 - 0.039 13.2 0.0 0.055 12.7 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.20 CCF44903.1 - 0.045 13.8 0.0 1.9 8.5 0.0 2.1 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.18 CCF44903.1 - 0.05 13.9 0.3 1.2 9.4 0.0 2.7 3 1 0 3 3 3 0 TrkA-N domain Transketolase_N PF00456.21 CCF44904.1 - 7.6e-124 413.0 0.2 9.5e-124 412.7 0.2 1.0 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain E1_dh PF00676.20 CCF44904.1 - 8.9e-07 28.1 0.0 1.3e-06 27.6 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.6 CCF44904.1 - 4.3e-06 26.1 0.0 1.1e-05 24.9 0.0 1.5 1 1 0 2 2 2 1 1-deoxy-D-xylulose-5-phosphate synthase DUF2263 PF10021.9 CCF44906.1 - 2.8e-13 50.5 0.0 5.4e-13 49.6 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2263) Chorion_2 PF03964.15 CCF44906.1 - 3.2 8.7 9.2 3 8.8 6.2 2.1 2 0 0 2 2 2 0 Chorion family 2 RSRP PF17069.5 CCF44906.1 - 9.8 5.6 20.2 17 4.8 20.2 1.3 1 0 0 1 1 1 0 Arginine/Serine-Rich protein 1 Candida_ALS PF05792.13 CCF44907.1 - 0.01 16.4 14.7 0.01 16.4 14.7 7.3 6 2 1 7 7 7 0 Candida agglutinin-like (ALS) MFS_1 PF07690.16 CCF44908.1 - 3.5e-19 68.9 26.0 5.8e-19 68.2 26.0 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.16 CCF44908.1 - 2.5e-12 46.8 5.2 2.5e-12 46.8 5.2 2.7 3 0 0 3 3 3 1 Ion channel regulatory protein UNC-93 DUF4689 PF15755.5 CCF44908.1 - 0.086 12.4 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4689) MFS_1_like PF12832.7 CCF44908.1 - 0.27 10.1 10.2 0.099 11.5 4.8 2.4 1 1 1 2 2 2 0 MFS_1 like family Sugar_tr PF00083.24 CCF44908.1 - 2.8 6.7 18.0 0.015 14.2 8.4 1.9 3 0 0 3 3 3 0 Sugar (and other) transporter Amidohydro_1 PF01979.20 CCF44911.1 - 1.5e-11 44.3 0.0 2.9e-09 36.7 0.0 2.3 2 0 0 2 2 2 2 Amidohydrolase family Amidohydro_3 PF07969.11 CCF44911.1 - 2.2e-09 37.3 0.1 1.9e-08 34.3 0.0 2.4 3 0 0 3 3 3 1 Amidohydrolase family tRNA_int_endo PF01974.17 CCF44911.1 - 0.12 12.5 0.0 4 7.6 0.0 2.8 3 0 0 3 3 3 0 tRNA intron endonuclease, catalytic C-terminal domain OPT PF03169.15 CCF44912.1 - 5.9e-99 332.4 17.9 7.3e-99 332.1 17.9 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Meth_synt_1 PF08267.12 CCF44913.1 - 2.4e-68 231.0 0.0 2.8e-68 230.7 0.0 1.0 1 0 0 1 1 1 1 Cobalamin-independent synthase, N-terminal domain RPA43_OB PF17875.1 CCF44914.1 - 1e-07 32.6 0.0 1e-07 32.6 0.0 3.8 2 1 1 4 4 4 1 RPA43 OB domain in RNA Pol I SHS2_Rpb7-N PF03876.17 CCF44914.1 - 1.1e-06 28.9 0.0 1.9e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 SOBP PF15279.6 CCF44914.1 - 2.4 8.7 11.5 3.3 8.2 11.5 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein MDM31_MDM32 PF08118.11 CCF44914.1 - 2.7 6.5 0.0 2.7 6.5 0.0 2.8 2 1 1 3 3 3 0 Yeast mitochondrial distribution and morphology (MDM) proteins Macoilin PF09726.9 CCF44914.1 - 6 5.3 13.0 7.6 5.0 13.0 1.2 1 0 0 1 1 1 0 Macoilin family RR_TM4-6 PF06459.12 CCF44914.1 - 8.1 6.2 30.5 12 5.6 30.5 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 NmrA PF05368.13 CCF44915.1 - 1.9e-14 53.8 0.0 2.2e-14 53.6 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CCF44915.1 - 9.9e-10 38.6 0.0 1.2e-09 38.3 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 CCF44915.1 - 2.5e-06 27.8 0.0 2.8e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain 3Beta_HSD PF01073.19 CCF44915.1 - 2.5e-06 26.7 0.0 2.9e-06 26.5 0.0 1.0 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Semialdhyde_dh PF01118.24 CCF44915.1 - 0.00025 21.5 0.0 0.0003 21.2 0.0 1.1 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain KR PF08659.10 CCF44915.1 - 0.00049 20.1 0.0 0.00057 19.8 0.0 1.1 1 0 0 1 1 1 1 KR domain Glu_dehyd_C PF16912.5 CCF44915.1 - 0.00092 18.8 0.0 0.001 18.6 0.0 1.1 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus Epimerase PF01370.21 CCF44915.1 - 0.00097 18.7 0.0 0.0011 18.5 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family TrkA_N PF02254.18 CCF44915.1 - 0.0038 17.5 0.1 0.0048 17.2 0.1 1.1 1 0 0 1 1 1 1 TrkA-N domain GDP_Man_Dehyd PF16363.5 CCF44915.1 - 0.0048 16.3 0.0 0.0058 16.1 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase adh_short PF00106.25 CCF44915.1 - 0.02 14.4 0.0 0.024 14.1 0.0 1.1 1 0 0 1 1 1 0 short chain dehydrogenase DUF5406 PF17400.2 CCF44915.1 - 0.041 14.3 0.0 0.059 13.8 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5406) Polysacc_synt_2 PF02719.15 CCF44915.1 - 0.062 12.4 0.0 0.072 12.2 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein dCMP_cyt_deam_1 PF00383.23 CCF44918.1 - 0.0026 17.6 0.0 0.0028 17.5 0.0 1.0 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 CCF44918.1 - 0.021 14.6 0.0 0.022 14.5 0.0 1.0 1 0 0 1 1 1 0 MafB19-like deaminase DUF3395 PF11875.8 CCF44920.1 - 0.025 14.5 0.1 0.049 13.5 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3395) F-box PF00646.33 CCF44920.1 - 0.044 13.7 0.1 5.6 7.0 0.0 2.6 2 0 0 2 2 2 0 F-box domain bZIP_1 PF00170.21 CCF44920.1 - 0.15 12.2 1.4 0.28 11.3 1.4 1.4 1 0 0 1 1 1 0 bZIP transcription factor SDA1 PF05285.12 CCF44920.1 - 4.8 6.5 14.8 6.7 6.0 14.8 1.2 1 0 0 1 1 1 0 SDA1 TFIIS_M PF07500.14 CCF44922.1 - 1.3e-28 99.7 1.5 1.3e-28 99.7 1.5 2.1 2 1 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.18 CCF44922.1 - 1.5e-18 66.4 6.0 2.6e-18 65.6 6.0 1.4 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Med26 PF08711.11 CCF44922.1 - 5.9e-12 45.4 0.4 1.6e-11 44.0 0.4 1.8 1 0 0 1 1 1 1 TFIIS helical bundle-like domain CPSF100_C PF13299.6 CCF44922.1 - 0.24 11.6 6.4 0.26 11.4 0.4 2.7 2 1 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal MbeB_N PF04837.12 CCF44922.1 - 0.98 9.8 5.1 13 6.2 0.1 2.8 2 0 0 2 2 2 0 MbeB-like, N-term conserved region Glyco_hydro_15 PF00723.21 CCF44923.1 - 3.1e-12 46.0 0.0 3.8e-12 45.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 KRE9 PF05390.11 CCF44924.1 - 0.085 13.6 0.4 0.17 12.6 0.2 1.6 2 0 0 2 2 2 0 Yeast cell wall synthesis protein KRE9/KNH1 Nup54_57_C PF18570.1 CCF44924.1 - 4 7.1 5.4 11 5.7 0.1 2.6 3 0 0 3 3 3 0 NUP57/Nup54 C-terminal domain Osw5 PF17062.5 CCF44929.1 - 0.019 15.0 1.3 0.023 14.8 1.3 1.1 1 0 0 1 1 1 0 Outer spore wall 5 TMEM191C PF15194.6 CCF44929.1 - 0.11 12.7 0.5 0.13 12.4 0.5 1.1 1 0 0 1 1 1 0 TMEM191C family Fungal_trans_2 PF11951.8 CCF44930.1 - 4.1e-08 32.4 0.4 2.1e-05 23.5 0.1 2.1 2 0 0 2 2 2 2 Fungal specific transcription factor domain GDP_Man_Dehyd PF16363.5 CCF44931.1 - 3.2e-40 138.5 0.0 6e-40 137.6 0.0 1.4 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 CCF44931.1 - 8.2e-40 136.8 0.0 1.1e-39 136.4 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CCF44931.1 - 2.3e-14 53.1 0.0 1.7e-13 50.3 0.0 1.9 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short PF00106.25 CCF44931.1 - 7.1e-08 32.1 0.0 3.7e-07 29.8 0.0 1.9 2 0 0 2 2 2 1 short chain dehydrogenase Polysacc_synt_2 PF02719.15 CCF44931.1 - 2.5e-06 26.8 0.0 0.00037 19.7 0.0 2.4 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 CCF44931.1 - 3.2e-06 26.4 0.0 5.8e-06 25.6 0.0 1.3 1 1 0 1 1 1 1 RmlD substrate binding domain KR PF08659.10 CCF44931.1 - 1.3e-05 25.2 0.0 0.0001 22.3 0.0 2.0 2 0 0 2 2 2 1 KR domain NAD_binding_10 PF13460.6 CCF44931.1 - 2.9e-05 24.0 0.0 4.6e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 CCF44931.1 - 6.5e-05 22.2 0.0 0.023 13.9 0.0 2.3 2 0 0 2 2 2 2 Male sterility protein UDPG_MGDP_dh_N PF03721.14 CCF44931.1 - 0.011 15.3 0.0 0.019 14.6 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NmrA PF05368.13 CCF44931.1 - 0.02 14.5 0.0 0.092 12.3 0.0 1.9 2 0 0 2 2 2 0 NmrA-like family adh_short_C2 PF13561.6 CCF44931.1 - 0.19 11.2 0.0 0.35 10.4 0.0 1.3 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase ADH_zinc_N_2 PF13602.6 CCF44932.1 - 7e-10 40.1 0.0 7.4e-10 40.0 0.0 1.0 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Peptidase_S8 PF00082.22 CCF44933.1 - 6e-42 143.9 2.9 6e-42 143.9 2.9 1.4 2 0 0 2 2 2 1 Subtilase family Inhibitor_I9 PF05922.16 CCF44933.1 - 0.098 13.3 0.0 0.27 11.9 0.0 1.8 2 0 0 2 2 2 0 Peptidase inhibitor I9 TauD PF02668.16 CCF44935.1 - 6.1e-24 85.2 0.5 1.1e-23 84.5 0.5 1.3 1 1 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family PGM_PMM_IV PF00408.20 CCF44936.1 - 0.15 12.2 0.0 0.31 11.2 0.0 1.5 1 0 0 1 1 1 0 Phosphoglucomutase/phosphomannomutase, C-terminal domain Zn_clus PF00172.18 CCF44937.1 - 3.1e-07 30.4 8.6 3.1e-07 30.4 8.6 2.0 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Abhydrolase_6 PF12697.7 CCF44938.1 - 5.8e-11 43.4 1.7 8e-11 43.0 1.7 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CCF44938.1 - 5.3e-07 29.5 0.1 1.6e-06 28.0 0.1 1.7 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CCF44938.1 - 1.7e-06 27.5 0.0 5.4e-06 25.9 0.0 1.6 1 1 0 2 2 2 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 CCF44938.1 - 3.7e-06 26.6 0.0 6.9e-06 25.7 0.0 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family DUF1100 PF06500.11 CCF44938.1 - 1.2e-05 24.3 0.0 1.8e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1100) Esterase PF00756.20 CCF44938.1 - 7.2e-05 22.5 0.1 0.00012 21.8 0.1 1.3 1 0 0 1 1 1 1 Putative esterase Abhydrolase_3 PF07859.13 CCF44938.1 - 0.0039 17.1 0.0 0.0058 16.5 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S15 PF02129.18 CCF44938.1 - 0.12 11.9 0.3 0.18 11.3 0.3 1.4 1 1 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) AXE1 PF05448.12 CCF44938.1 - 0.15 10.7 0.1 0.3 9.7 0.1 1.7 1 1 0 1 1 1 0 Acetyl xylan esterase (AXE1) DLH PF01738.18 CCF44938.1 - 0.18 11.3 0.0 0.5 9.9 0.0 1.6 2 0 0 2 2 2 0 Dienelactone hydrolase family ADH_zinc_N PF00107.26 CCF44939.1 - 7.4e-06 26.0 0.0 9.4e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Mito_carr PF00153.27 CCF44940.1 - 2.4e-52 174.9 5.6 4.4e-19 68.2 0.2 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 CCF44940.1 - 0.024 13.8 2.0 0.05 12.7 0.1 2.3 3 0 0 3 3 3 0 Gammaproteobacterial serine protease Sugar_tr PF00083.24 CCF44941.1 - 1.6e-80 271.2 15.8 2e-80 270.9 15.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF44941.1 - 3.4e-23 82.1 23.5 1.2e-21 77.1 12.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 CCF44941.1 - 0.00099 17.8 2.5 0.00099 17.8 2.5 2.5 2 0 0 2 2 2 1 MFS/sugar transport protein TRI12 PF06609.13 CCF44941.1 - 0.0067 14.9 0.7 0.011 14.2 0.7 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) JmjC PF02373.22 CCF44942.1 - 2e-36 124.9 0.5 2e-36 124.9 0.5 2.1 2 0 0 2 2 2 1 JmjC domain, hydroxylase zf-HC5HC2H_2 PF13832.6 CCF44942.1 - 4.9e-21 75.0 4.7 9.1e-21 74.1 4.7 1.5 1 0 0 1 1 1 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 CCF44942.1 - 1.1e-20 73.7 9.4 1.4e-20 73.3 5.1 2.4 2 0 0 2 2 2 1 PHD-like zinc-binding domain JmjN PF02375.17 CCF44942.1 - 4.5e-12 45.7 1.0 1e-11 44.6 1.0 1.7 1 0 0 1 1 1 1 jmjN domain ERAP1_C PF11838.8 CCF44943.1 - 1.7e-88 297.2 0.0 6.9e-88 295.2 0.0 1.9 2 0 0 2 2 2 1 ERAP1-like C-terminal domain Peptidase_M1 PF01433.20 CCF44943.1 - 6.2e-79 264.6 3.7 8.8e-79 264.1 3.8 1.2 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 CCF44943.1 - 8.1e-50 169.6 2.2 9.6e-50 169.4 1.2 1.7 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain DUF45 PF01863.17 CCF44943.1 - 0.016 15.2 0.1 0.31 11.1 0.1 2.7 2 1 1 3 3 3 0 Protein of unknown function DUF45 HTH_Tnp_Tc5 PF03221.16 CCF44944.1 - 2e-10 40.5 0.0 1.3e-09 37.9 0.0 2.0 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 CCF44944.1 - 1.1e-08 34.7 0.0 2.1e-08 33.7 0.0 1.5 2 0 0 2 2 2 1 helix-turn-helix, Psq domain HTH_23 PF13384.6 CCF44944.1 - 0.00046 19.9 0.1 0.001 18.8 0.1 1.6 1 0 0 1 1 1 1 Homeodomain-like domain HTH_30 PF13556.6 CCF44944.1 - 0.0032 17.2 0.0 0.0071 16.1 0.0 1.6 2 0 0 2 2 2 1 PucR C-terminal helix-turn-helix domain Glycos_transf_3 PF00591.21 CCF44945.1 - 0.13 11.8 0.0 0.14 11.7 0.0 1.1 1 0 0 1 1 1 0 Glycosyl transferase family, a/b domain Fungal_trans PF04082.18 CCF44946.1 - 2.8e-08 33.1 0.0 4e-08 32.6 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain DDE_1 PF03184.19 CCF44947.1 - 1.2e-14 54.4 0.0 1.4e-14 54.1 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease YL1_C PF08265.11 CCF44948.1 - 3.2e-14 52.4 0.5 5.4e-14 51.7 0.5 1.4 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain zf-HIT PF04438.16 CCF44948.1 - 0.12 12.2 0.0 0.21 11.5 0.0 1.3 1 0 0 1 1 1 0 HIT zinc finger Menin PF05053.13 CCF44948.1 - 1.8 6.8 4.9 2.2 6.5 4.9 1.1 1 0 0 1 1 1 0 Menin Ndc1_Nup PF09531.10 CCF44948.1 - 2.7 6.6 8.1 3 6.4 8.1 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup FAM75 PF14650.6 CCF44948.1 - 5.5 6.4 16.7 7.6 6.0 16.7 1.2 1 0 0 1 1 1 0 FAM75 family Nucleo_P87 PF07267.11 CCF44949.1 - 0.89 8.3 2.4 1.1 8.0 2.4 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 PMI_typeI PF01238.21 CCF44950.1 - 5.2e-41 141.1 0.0 5.6e-41 141.0 0.0 1.0 1 0 0 1 1 1 1 Phosphomannose isomerase type I Adaptin_N PF01602.20 CCF44953.1 - 1.1e-123 413.6 9.9 1.3e-123 413.3 9.9 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptin_C PF02296.16 CCF44953.1 - 3.5e-47 159.3 0.0 9.9e-47 157.8 0.0 1.9 1 0 0 1 1 1 1 Alpha adaptin AP2, C-terminal domain Alpha_adaptinC2 PF02883.20 CCF44953.1 - 1.1e-15 57.8 0.0 2e-15 57.1 0.0 1.4 1 0 0 1 1 1 1 Adaptin C-terminal domain FAD_binding_4 PF01565.23 CCF44955.1 - 1.8e-10 40.7 0.0 2.5e-10 40.2 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain LCM PF04072.14 CCF44958.1 - 1.5e-20 74.0 0.0 2.1e-20 73.5 0.0 1.2 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase Kelch_4 PF13418.6 CCF44958.1 - 0.0012 18.8 0.1 0.0051 16.8 0.1 2.1 2 0 0 2 2 2 1 Galactose oxidase, central domain C1_2 PF03107.16 CCF44960.1 - 0.023 15.0 6.6 0.034 14.5 6.6 1.2 1 0 0 1 1 1 0 C1 domain p450 PF00067.22 CCF44961.1 - 1.1e-46 159.5 0.0 1.7e-46 159.0 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 CUE PF02845.16 CCF44964.1 - 5.1e-11 42.0 0.0 7.7e-11 41.5 0.0 1.3 1 0 0 1 1 1 1 CUE domain G2BR PF18442.1 CCF44964.1 - 0.081 12.6 8.6 0.22 11.2 8.6 1.7 1 0 0 1 1 1 0 E3 gp78 Ube2g2-binding region (G2BR) VIR_N PF15912.5 CCF44964.1 - 0.5 9.9 9.2 0.12 11.9 4.9 1.9 2 1 0 2 2 2 0 Virilizer, N-terminal NOT2_3_5 PF04153.18 CCF44965.1 - 1.3e-24 86.7 0.4 1.9e-24 86.2 0.4 1.2 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family cobW PF02492.19 CCF44966.1 - 3.5e-27 95.1 0.1 5.1e-27 94.6 0.1 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 CCF44966.1 - 7.7e-05 22.5 0.1 0.00016 21.6 0.1 1.5 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain RsgA_GTPase PF03193.16 CCF44966.1 - 0.12 12.3 0.0 0.27 11.1 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase PND PF17949.1 CCF44966.1 - 0.17 12.2 0.1 0.45 10.8 0.0 1.7 2 0 0 2 2 2 0 FANCM pseudonuclease domain Rxt3 PF08642.10 CCF44967.1 - 3.9e-46 157.0 0.8 7.2e-46 156.1 0.0 1.8 2 0 0 2 2 2 1 Histone deacetylation protein Rxt3 LCCL PF03815.19 CCF44967.1 - 4.7e-06 26.6 0.0 0.0018 18.3 0.0 2.4 2 0 0 2 2 2 2 LCCL domain PBP PF01161.20 CCF44969.1 - 1.7e-07 31.6 0.0 3.8e-07 30.5 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein Tmemb_cc2 PF10267.9 CCF44970.1 - 0.13 11.4 11.6 0.15 11.2 11.6 1.0 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein YL1 PF05764.13 CCF44970.1 - 0.33 11.0 25.6 0.5 10.4 25.6 1.3 1 0 0 1 1 1 0 YL1 nuclear protein DOR PF14839.6 CCF44970.1 - 0.65 9.9 8.9 0.77 9.7 8.9 1.2 1 0 0 1 1 1 0 DOR family Nop53 PF07767.11 CCF44970.1 - 1.2 8.5 27.9 1.4 8.2 27.9 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) YjbH PF06082.11 CCF44970.1 - 1.6 7.4 6.1 1.7 7.3 6.1 1.0 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH RRN9 PF10680.9 CCF44971.1 - 4.3e-14 52.5 5.0 4.3e-14 52.5 5.0 3.2 2 2 0 2 2 2 1 RNA polymerase I specific transcription initiation factor HeLo PF14479.6 CCF44975.1 - 6.2e-36 124.2 0.0 6.9e-36 124.0 0.0 1.0 1 0 0 1 1 1 1 Prion-inhibition and propagation LamB_YcsF PF03746.16 CCF44976.1 - 2.4e-82 276.2 0.0 2.7e-82 276.1 0.0 1.0 1 0 0 1 1 1 1 LamB/YcsF family EHN PF06441.12 CCF44977.1 - 2.9e-37 127.3 1.4 7e-36 122.9 0.1 2.3 2 0 0 2 2 2 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 CCF44977.1 - 1.2e-13 51.3 0.0 1.9e-13 50.7 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCF44977.1 - 3e-05 24.7 1.5 3e-05 24.7 1.5 1.6 2 0 0 2 2 2 1 Alpha/beta hydrolase family Dodecin PF07311.12 CCF44980.1 - 0.032 14.5 2.2 0.72 10.1 0.3 3.0 2 1 1 3 3 3 0 Dodecin DUF1490 PF07371.12 CCF44980.1 - 0.22 11.6 3.3 2.6 8.2 0.3 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF1490) Peptidase_S10 PF00450.22 CCF44981.1 - 2.2e-72 244.8 0.4 3.1e-72 244.3 0.4 1.2 1 0 0 1 1 1 1 Serine carboxypeptidase MFS_1 PF07690.16 CCF44982.1 - 5.4e-06 25.6 22.0 5.4e-06 25.6 22.0 1.9 2 1 0 2 2 2 1 Major Facilitator Superfamily DUF5056 PF16479.5 CCF44982.1 - 0.065 13.5 0.1 0.065 13.5 0.1 2.2 3 0 0 3 3 3 0 Domain of unknown function (DUF5056) Bac_export_2 PF01312.19 CCF44982.1 - 0.1 11.8 2.3 0.1 11.8 1.0 1.7 1 1 1 2 2 2 0 FlhB HrpN YscU SpaS Family Cnn_1N PF07989.11 CCF44987.1 - 6.9e-22 77.4 9.0 6.9e-22 77.4 9.0 12.5 9 1 2 12 12 12 4 Centrosomin N-terminal motif 1 Mto2_bdg PF12808.7 CCF44987.1 - 2.1e-11 43.9 8.8 2.1e-11 43.9 8.8 13.7 14 2 2 16 16 16 2 Micro-tubular organiser Mto1 C-term Mto2-binding region DegS PF05384.11 CCF44987.1 - 0.00094 18.7 3.6 0.00094 18.7 3.6 9.0 5 2 5 11 11 11 1 Sensor protein DegS NPV_P10 PF05531.12 CCF44987.1 - 1.8 9.1 0.0 1.8 9.1 0.0 7.2 7 1 0 7 7 7 0 Nucleopolyhedrovirus P10 protein DUF1479 PF07350.12 CCF44988.1 - 2.4e-160 533.9 0.0 2.8e-160 533.6 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1479) PhyH PF05721.13 CCF44988.1 - 0.021 15.1 0.1 2.1 8.5 0.0 2.3 2 0 0 2 2 2 0 Phytanoyl-CoA dioxygenase (PhyH) TauD PF02668.16 CCF44988.1 - 0.028 14.2 0.0 9 6.0 0.0 2.2 2 0 0 2 2 2 0 Taurine catabolism dioxygenase TauD, TfdA family Methyltransf_11 PF08241.12 CCF44989.1 - 2.9e-08 34.2 0.0 7.6e-08 32.9 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF44989.1 - 3.4e-07 30.9 0.0 7.7e-07 29.7 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF44989.1 - 0.00021 21.1 0.0 0.00025 20.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF44989.1 - 0.006 17.3 0.0 0.0088 16.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain DUF1993 PF09351.10 CCF44990.1 - 5.1e-54 182.8 0.0 5.8e-54 182.6 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1993) PepSY_TM PF03929.16 CCF44991.1 - 0.13 11.9 0.0 0.21 11.2 0.0 1.4 1 0 0 1 1 1 0 PepSY-associated TM region adh_short PF00106.25 CCF44992.1 - 5e-23 81.6 1.4 2e-20 73.1 1.5 2.1 2 0 0 2 2 2 2 short chain dehydrogenase KR PF08659.10 CCF44992.1 - 5.4e-12 46.0 1.4 7.9e-12 45.4 1.4 1.2 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.6 CCF44992.1 - 2.2e-11 43.8 1.4 1.4e-08 34.6 1.8 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase Polysacc_synt_2 PF02719.15 CCF44992.1 - 0.014 14.6 0.3 0.019 14.1 0.3 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Shikimate_DH PF01488.20 CCF44992.1 - 0.026 14.6 0.5 0.056 13.5 0.1 1.7 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Epimerase PF01370.21 CCF44992.1 - 0.027 13.9 0.0 0.034 13.6 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Sugar_tr PF00083.24 CCF44994.1 - 9.3e-75 252.2 10.4 1.1e-74 251.9 10.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF44994.1 - 1.3e-10 40.7 18.8 1.3e-10 40.7 18.8 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily NAD_binding_10 PF13460.6 CCF44995.1 - 1.9e-14 54.0 0.0 8.1e-14 51.9 0.0 1.9 2 0 0 2 2 2 1 NAD(P)H-binding NmrA PF05368.13 CCF44995.1 - 2.1e-13 50.4 0.0 2.9e-13 49.9 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 CCF44995.1 - 0.00026 20.5 0.0 0.00044 19.8 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 CCF44995.1 - 0.019 15.4 0.1 0.037 14.4 0.1 1.5 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 CCF44995.1 - 0.089 12.8 0.0 0.13 12.3 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Ldh_1_N PF00056.23 CCF44995.1 - 0.2 11.7 0.3 0.5 10.5 0.3 1.8 1 1 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain PhoD PF09423.10 CCF44996.1 - 1.8e-115 385.7 3.3 2.2e-115 385.5 3.3 1.1 1 0 0 1 1 1 1 PhoD-like phosphatase PhoD_N PF16655.5 CCF44996.1 - 3.2e-32 110.9 0.6 7.9e-32 109.7 0.6 1.7 1 0 0 1 1 1 1 PhoD-like phosphatase, N-terminal domain Pur_ac_phosph_N PF16656.5 CCF44996.1 - 7.7e-05 23.2 1.7 0.0003 21.3 1.7 2.1 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain Glyco_hydro_3 PF00933.21 CCF44999.1 - 3e-37 128.7 0.0 4.2e-37 128.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain NAD_binding_8 PF13450.6 CCF45000.1 - 0.0012 19.1 0.0 0.0021 18.2 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 CCF45000.1 - 0.008 16.2 0.5 0.017 15.1 0.5 1.8 1 1 0 1 1 1 1 FAD-NAD(P)-binding Thi4 PF01946.17 CCF45000.1 - 0.039 13.2 0.0 0.06 12.6 0.0 1.2 1 0 0 1 1 1 0 Thi4 family Glu_dehyd_C PF16912.5 CCF45000.1 - 0.067 12.7 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus Pyr_redox_2 PF07992.14 CCF45000.1 - 0.11 11.7 0.0 0.18 11.0 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 CCF45000.1 - 0.3 9.4 0.0 0.82 8.0 0.0 1.6 2 0 0 2 2 2 0 Flavin-binding monooxygenase-like GDP_Man_Dehyd PF16363.5 CCF45001.1 - 1.8e-06 27.6 0.0 1.8e-06 27.6 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 CCF45001.1 - 4.2e-06 26.4 0.0 4.7e-06 26.3 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 CCF45001.1 - 0.00049 19.7 0.0 0.00057 19.5 0.0 1.0 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CCF45001.1 - 0.0007 19.5 0.0 0.00082 19.3 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding adh_short PF00106.25 CCF45001.1 - 0.021 14.3 0.0 0.023 14.2 0.0 1.0 1 0 0 1 1 1 0 short chain dehydrogenase MFS_1 PF07690.16 CCF45002.1 - 1.6e-09 37.2 22.8 2.9e-09 36.3 22.1 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily PUCC PF03209.15 CCF45002.1 - 0.0074 15.3 9.8 0.05 12.6 7.5 2.1 1 1 1 2 2 2 2 PUCC protein DNA_pol_delta_4 PF04081.13 CCF45002.1 - 0.09 13.1 0.0 0.15 12.4 0.0 1.2 1 0 0 1 1 1 0 DNA polymerase delta, subunit 4 Sugar_tr PF00083.24 CCF45003.1 - 2.8e-53 181.4 2.3 3.3e-53 181.1 2.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF45003.1 - 4.2e-17 62.1 6.3 5.4e-17 61.7 6.3 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily PSRP-3_Ycf65 PF04839.13 CCF45004.1 - 0.068 13.4 0.1 0.11 12.7 0.1 1.3 1 0 0 1 1 1 0 Plastid and cyanobacterial ribosomal protein (PSRP-3 / Ycf65) DUF1479 PF07350.12 CCF45006.1 - 4.1e-161 536.4 0.0 4.8e-161 536.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1479) HHH PF00633.23 CCF45007.1 - 0.0072 16.2 0.1 0.015 15.1 0.1 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif TIP49_C PF17856.1 CCF45007.1 - 0.031 14.4 0.0 0.073 13.2 0.0 1.6 1 0 0 1 1 1 0 TIP49 AAA-lid domain HHH_5 PF14520.6 CCF45007.1 - 0.11 13.1 0.0 0.25 12.0 0.0 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix domain zf-met2 PF12907.7 CCF45008.1 - 1.2e-16 60.5 3.1 2.2e-16 59.7 3.1 1.4 1 0 0 1 1 1 1 Zinc-binding 4F5 PF04419.14 CCF45008.1 - 2.7e-05 25.0 9.5 2.7e-05 25.0 9.5 1.5 2 0 0 2 2 2 1 4F5 protein family DIOX_N PF14226.6 CCF45009.1 - 2.3e-33 115.4 0.0 3.4e-32 111.7 0.0 2.1 2 0 0 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 CCF45009.1 - 2.4e-13 50.4 0.0 5.1e-13 49.4 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily WD40 PF00400.32 CCF45010.1 - 0.00028 21.6 5.8 0.37 11.8 0.1 4.9 5 0 0 5 5 5 1 WD domain, G-beta repeat Harakiri PF15196.6 CCF45010.1 - 0.0043 17.5 0.3 0.55 10.7 0.1 2.4 2 0 0 2 2 2 1 Activator of apoptosis harakiri Peptidase_S9_N PF02897.15 CCF45010.1 - 0.035 12.9 0.0 0.064 12.1 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase, N-terminal beta-propeller domain PQQ PF01011.21 CCF45010.1 - 0.045 13.7 0.2 0.25 11.4 0.2 2.3 1 0 0 1 1 1 0 PQQ enzyme repeat PD40 PF07676.12 CCF45010.1 - 0.068 13.1 0.1 7.6 6.6 0.0 2.9 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat Lactonase PF10282.9 CCF45010.1 - 0.09 12.0 0.0 0.3 10.3 0.0 1.8 2 0 0 2 2 2 0 Lactonase, 7-bladed beta-propeller PQQ_3 PF13570.6 CCF45010.1 - 0.18 12.4 0.8 1 9.9 0.2 2.7 2 0 0 2 2 2 0 PQQ-like domain AA_permease PF00324.21 CCF45011.1 - 6.5e-35 120.6 21.4 7.7e-35 120.4 21.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CCF45011.1 - 1.2e-09 37.5 17.1 1.5e-09 37.2 17.1 1.0 1 0 0 1 1 1 1 Amino acid permease TcpE PF12648.7 CCF45011.1 - 3.4 8.2 8.0 7.1 7.2 8.0 1.5 1 0 0 1 1 1 0 TcpE family Peptidase_A22B PF04258.13 CCF45012.1 - 1.1e-17 64.5 4.3 1.5e-17 64.1 4.3 1.2 1 0 0 1 1 1 1 Signal peptide peptidase PHO4 PF01384.20 CCF45012.1 - 0.017 14.2 0.9 0.021 13.9 0.9 1.1 1 0 0 1 1 1 0 Phosphate transporter family Flu_M2 PF00599.17 CCF45012.1 - 0.22 11.6 1.0 1.2 9.2 0.2 2.4 2 1 0 2 2 2 0 Influenza Matrix protein (M2) CHZ PF09649.10 CCF45014.1 - 1.4e-16 59.6 1.7 1.4e-16 59.6 1.7 2.4 2 0 0 2 2 2 1 Histone chaperone domain CHZ VIT1 PF01988.19 CCF45014.1 - 0.75 9.6 1.9 0.88 9.4 1.9 1.1 1 0 0 1 1 1 0 VIT family ADH_N PF08240.12 CCF45016.1 - 5.5e-07 29.5 0.4 4.8e-05 23.2 0.1 2.2 1 1 1 2 2 2 2 Alcohol dehydrogenase GroES-like domain ketoacyl-synt PF00109.26 CCF45017.1 - 1.9e-68 230.8 0.0 2.1e-68 230.6 0.0 1.0 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Thiolase_N PF00108.23 CCF45017.1 - 0.00076 18.9 0.1 0.0012 18.3 0.1 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain ACP_syn_III PF08545.10 CCF45017.1 - 0.016 15.1 0.5 0.035 14.0 0.4 1.6 1 1 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Enolase_N PF03952.16 CCF45017.1 - 0.076 13.2 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 Enolase, N-terminal domain MDMPI_C PF07398.11 CCF45018.1 - 0.033 15.0 0.2 0.062 14.2 0.2 1.7 1 1 0 1 1 1 0 MDMPI C-terminal domain zf-C2H2 PF00096.26 CCF45020.1 - 5.1e-06 26.7 11.6 0.0025 18.2 1.6 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCF45020.1 - 0.00023 21.7 11.0 0.07 14.0 2.9 3.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 CCF45020.1 - 0.00026 21.3 3.8 0.00026 21.3 3.8 2.7 4 0 0 4 4 4 1 Zinc-finger double domain DUF3821 PF12863.7 CCF45020.1 - 0.061 13.2 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3821) Nucleo_P87 PF07267.11 CCF45020.1 - 0.14 11.0 8.2 0.11 11.3 6.4 1.6 2 0 0 2 2 2 0 Nucleopolyhedrovirus capsid protein P87 PBP1_TM PF14812.6 CCF45020.1 - 2.1 8.8 7.6 5.1 7.5 7.6 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal MCM PF00493.23 CCF45021.1 - 4.2e-99 330.2 1.8 6.7e-99 329.5 0.0 2.0 2 0 0 2 2 2 1 MCM P-loop domain MCM_OB PF17207.3 CCF45021.1 - 1.2e-38 131.8 0.1 2.2e-38 130.9 0.1 1.4 1 0 0 1 1 1 1 MCM OB domain MCM2_N PF12619.8 CCF45021.1 - 8.9e-35 120.2 34.0 8.9e-35 120.2 34.0 2.3 3 0 0 3 3 3 1 Mini-chromosome maintenance protein 2 MCM_lid PF17855.1 CCF45021.1 - 2.9e-26 91.7 0.8 7.8e-26 90.3 0.8 1.8 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 CCF45021.1 - 5e-15 56.0 0.1 1.4e-14 54.5 0.1 1.8 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 CCF45021.1 - 1.1e-07 31.5 0.9 5.6e-06 25.9 0.0 2.9 2 1 0 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 CCF45021.1 - 1.8e-06 28.0 0.0 4.2e-06 26.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 CCF45021.1 - 0.0029 17.5 0.1 0.013 15.3 0.0 2.1 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 CCF45021.1 - 0.0031 17.2 0.2 0.023 14.4 0.2 2.0 1 1 0 1 1 1 1 Sigma-54 interaction domain Zn_ribbon_2 PF12674.7 CCF45021.1 - 0.2 12.3 0.3 0.7 10.6 0.3 1.9 1 0 0 1 1 1 0 Putative zinc ribbon domain zf-rbx1 PF12678.7 CCF45023.1 - 9.8e-11 41.8 14.9 2.3e-08 34.2 0.4 3.8 3 1 1 4 4 4 2 RING-H2 zinc finger domain PHD PF00628.29 CCF45023.1 - 9.1e-09 35.1 15.1 1.6e-08 34.3 7.4 2.8 2 0 0 2 2 2 1 PHD-finger zf-RING_2 PF13639.6 CCF45023.1 - 3.8e-08 33.5 1.2 3.8e-08 33.5 1.2 4.3 4 1 0 4 4 4 2 Ring finger domain zf-C3HC4 PF00097.25 CCF45023.1 - 4.2e-06 26.5 2.3 4.2e-06 26.5 2.3 3.4 2 2 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) PHD_2 PF13831.6 CCF45023.1 - 9.8e-06 25.0 3.3 9.8e-06 25.0 3.3 2.6 2 0 0 2 2 2 1 PHD-finger Prok-RING_4 PF14447.6 CCF45023.1 - 1.6e-05 24.6 1.0 1.6e-05 24.6 1.0 3.8 5 0 0 5 5 3 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 CCF45023.1 - 1.9e-05 24.4 0.6 1.9e-05 24.4 0.6 3.9 4 1 0 4 4 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CCF45023.1 - 3.8e-05 23.5 0.4 3.8e-05 23.5 0.4 5.1 4 1 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CCF45023.1 - 0.00014 21.7 0.5 0.00014 21.7 0.5 4.0 5 0 0 5 5 4 1 zinc-RING finger domain PHF5 PF03660.14 CCF45023.1 - 0.0011 19.1 1.7 0.0011 19.1 1.7 2.4 3 0 0 3 3 3 1 PHF5-like protein zf-ANAPC11 PF12861.7 CCF45023.1 - 0.002 18.2 11.7 0.019 15.0 1.2 2.8 1 1 0 2 2 2 2 Anaphase-promoting complex subunit 11 RING-H2 finger zf-PHD-like PF15446.6 CCF45023.1 - 0.0027 17.4 2.1 0.0027 17.4 2.1 2.5 2 0 0 2 2 2 1 PHD/FYVE-zinc-finger like domain Zn_ribbon_17 PF17120.5 CCF45023.1 - 0.0031 17.1 1.5 0.0031 17.1 1.5 3.2 3 0 0 3 3 3 1 Zinc-ribbon, C4HC2 type zf-RING_UBOX PF13445.6 CCF45023.1 - 0.0092 16.0 0.2 0.0092 16.0 0.2 4.6 3 2 1 4 4 4 1 RING-type zinc-finger zf-P11 PF03854.14 CCF45023.1 - 0.026 14.2 0.4 0.026 14.2 0.4 2.7 4 0 0 4 4 3 0 P-11 zinc finger Rtf2 PF04641.12 CCF45023.1 - 0.043 13.2 0.2 0.043 13.2 0.2 1.8 2 1 0 2 2 1 0 Rtf2 RING-finger Prok-RING_1 PF14446.6 CCF45023.1 - 0.11 12.4 10.5 0.13 12.2 2.6 3.1 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 Rad50_zn_hook PF04423.14 CCF45023.1 - 0.13 12.1 2.4 0.29 11.0 0.1 2.2 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-UDP PF14569.6 CCF45023.1 - 0.15 12.2 0.7 1.5 9.0 0.0 2.4 2 0 0 2 2 2 0 Zinc-binding RING-finger YdjO PF14169.6 CCF45023.1 - 0.29 10.9 2.1 5.2 6.9 0.3 2.7 2 0 0 2 2 2 0 Cold-inducible protein YdjO Zf_RING PF16744.5 CCF45023.1 - 0.34 11.0 9.4 0.43 10.7 1.7 3.0 2 1 0 2 2 2 0 KIAA1045 RING finger zf-RING_9 PF13901.6 CCF45023.1 - 1.1 9.2 11.6 3 7.8 0.6 2.5 2 1 0 2 2 2 0 Putative zinc-RING and/or ribbon DUF1644 PF07800.12 CCF45023.1 - 1.4 9.0 8.6 11 6.0 5.2 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1644) zf-RING_6 PF14835.6 CCF45023.1 - 5.6 6.9 8.5 0.24 11.3 0.2 2.8 3 0 0 3 3 3 0 zf-RING of BARD1-type protein VPS13_C PF16909.5 CCF45024.1 - 5.1e-78 260.9 5.6 9.1e-72 240.6 0.3 2.2 2 0 0 2 2 2 2 Vacuolar-sorting-associated 13 protein C-terminal ATG_C PF09333.11 CCF45024.1 - 1.2e-09 38.4 0.0 1.3e-08 35.1 0.0 2.2 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain FRG2 PF15315.6 CCF45026.1 - 3.3 7.9 24.4 3.8 7.7 24.4 1.0 1 0 0 1 1 1 0 Facioscapulohumeral muscular dystrophy candidate 2 WD40 PF00400.32 CCF45027.1 - 4.3e-18 65.3 1.2 4.9e-09 36.7 0.2 2.0 2 0 0 2 2 2 2 WD domain, G-beta repeat Ge1_WD40 PF16529.5 CCF45027.1 - 2e-06 27.0 0.6 0.017 14.1 0.2 2.0 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 CCF45027.1 - 9.2e-06 25.9 0.0 0.028 14.7 0.0 2.0 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 CCF45027.1 - 0.0034 17.0 0.2 0.0036 16.9 0.2 1.1 1 0 0 1 1 1 1 PQQ-like domain Nup160 PF11715.8 CCF45027.1 - 0.016 13.8 0.0 0.016 13.8 0.0 1.0 1 0 0 1 1 1 0 Nucleoporin Nup120/160 SEF14_adhesin PF06443.11 CCF45027.1 - 0.041 13.8 0.3 0.047 13.5 0.3 1.0 1 0 0 1 1 1 0 SEF14-like adhesin Big_3_5 PF16640.5 CCF45027.1 - 0.093 12.9 1.8 1.2 9.4 1.8 2.0 1 1 0 1 1 1 0 Bacterial Ig-like domain (group 3) Vps62 PF06101.11 CCF45029.1 - 6.9e-11 41.2 0.1 6.9e-11 41.2 0.1 2.2 3 0 0 3 3 3 1 Vacuolar protein sorting-associated protein 62 Carb_anhydrase PF00194.21 CCF45030.1 - 1.1e-09 38.2 0.0 1.3e-09 38.0 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Ribosomal_60s PF00428.19 CCF45030.1 - 4 8.1 12.4 6 7.5 12.4 1.3 1 0 0 1 1 1 0 60s Acidic ribosomal protein Glyco_hydro_28 PF00295.17 CCF45031.1 - 2.6e-35 122.0 2.0 3.2e-35 121.7 2.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Pectate_lyase PF03211.13 CCF45035.1 - 1.2e-77 260.1 5.9 1.4e-77 259.8 5.9 1.0 1 0 0 1 1 1 1 Pectate lyase Tannase PF07519.11 CCF45036.1 - 1.3e-90 304.6 0.2 1.5e-90 304.3 0.2 1.0 1 0 0 1 1 1 1 Tannase and feruloyl esterase Peptidase_S9 PF00326.21 CCF45036.1 - 0.0004 19.9 0.1 0.34 10.3 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 CCF45036.1 - 0.00041 19.7 0.0 0.005 16.1 0.0 2.2 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CCF45036.1 - 0.0022 17.7 0.0 0.0049 16.6 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Esterase PF00756.20 CCF45036.1 - 0.084 12.5 0.0 0.18 11.4 0.0 1.5 1 0 0 1 1 1 0 Putative esterase Cu-oxidase PF00394.22 CCF45037.1 - 2.5e-28 99.2 0.0 3.8e-28 98.6 0.0 1.3 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 CCF45037.1 - 2.3e-25 88.9 0.4 4.7e-25 87.9 0.4 1.5 1 0 0 1 1 1 1 Multicopper oxidase Sec34 PF04136.15 CCF45038.1 - 1.8e-50 170.7 1.2 1.8e-50 170.7 1.2 2.3 3 0 0 3 3 3 1 Sec34-like family NTP_transf_3 PF12804.7 CCF45039.1 - 0.046 14.1 0.0 0.048 14.0 0.0 1.1 1 0 0 1 1 1 0 MobA-like NTP transferase domain PhoLip_ATPase_C PF16212.5 CCF45040.1 - 1.2e-50 172.7 7.6 1.5e-50 172.3 7.6 1.1 1 0 0 1 1 1 1 Phospholipid-translocating P-type ATPase C-terminal Hydrolase PF00702.26 CCF45040.1 - 5.7e-11 43.1 0.0 0.00015 22.2 0.0 2.2 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 CCF45040.1 - 0.00041 20.2 0.1 0.00072 19.4 0.1 1.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF2183 PF09949.9 CCF45040.1 - 0.087 13.2 0.0 0.34 11.3 0.0 2.0 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2183) UIM PF02809.20 CCF45041.1 - 0.083 12.8 0.5 0.14 12.1 0.5 1.4 1 0 0 1 1 1 0 Ubiquitin interaction motif UBA_4 PF14555.6 CCF45041.1 - 0.093 12.6 0.0 0.21 11.4 0.0 1.7 1 0 0 1 1 1 0 UBA-like domain SOBP PF15279.6 CCF45042.1 - 1.7 9.2 22.8 1.4 9.5 21.6 1.4 1 1 0 1 1 1 0 Sine oculis-binding protein Helicase_C PF00271.31 CCF45043.1 - 6.2e-07 29.7 0.1 1.6e-06 28.4 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain EnY2 PF10163.9 CCF45043.1 - 0.0056 17.0 0.0 0.018 15.4 0.0 1.9 1 0 0 1 1 1 1 Transcription factor e(y)2 adh_short PF00106.25 CCF45044.1 - 8.7e-20 71.0 0.0 3e-18 66.0 0.0 2.0 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF45044.1 - 2.5e-08 33.8 0.0 1.1e-07 31.7 0.0 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 CCF45044.1 - 0.00049 19.6 0.0 0.0013 18.3 0.0 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 CCF45044.1 - 0.00062 19.7 0.0 0.0011 18.9 0.0 1.4 1 0 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 CCF45044.1 - 0.0011 18.5 0.0 0.0068 15.8 0.0 1.8 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase Shikimate_DH PF01488.20 CCF45044.1 - 0.0089 16.1 0.0 0.013 15.5 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_4 PF07993.12 CCF45044.1 - 0.011 14.9 0.0 0.017 14.3 0.0 1.4 1 1 0 1 1 1 0 Male sterility protein NAD_binding_10 PF13460.6 CCF45044.1 - 0.014 15.3 0.1 0.071 13.0 0.0 1.9 2 0 0 2 2 2 0 NAD(P)H-binding Polysacc_synt_2 PF02719.15 CCF45044.1 - 0.018 14.2 0.0 0.024 13.8 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Semialdhyde_dh PF01118.24 CCF45044.1 - 0.17 12.3 0.0 0.36 11.3 0.0 1.5 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Ank_4 PF13637.6 CCF45045.1 - 8.4e-12 45.4 0.0 1.1e-07 32.2 0.0 4.1 2 1 2 4 4 4 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 CCF45045.1 - 3.5e-11 43.5 0.0 3.9e-10 40.2 0.0 2.5 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CCF45045.1 - 5.4e-10 38.6 0.0 4.5e-05 23.5 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank PF00023.30 CCF45045.1 - 1.2e-09 38.1 0.0 0.00015 22.0 0.0 3.2 3 1 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 CCF45045.1 - 2.8e-06 27.5 0.0 7.9e-05 22.9 0.0 2.8 1 1 2 3 3 3 2 Ankyrin repeats (many copies) NMD3 PF04981.13 CCF45046.1 - 1.7e-77 260.2 3.1 2.6e-77 259.6 3.1 1.3 1 0 0 1 1 1 1 NMD3 family Nif11 PF07862.11 CCF45046.1 - 0.33 11.3 1.6 0.76 10.1 0.4 2.2 2 0 0 2 2 2 0 Nif11 domain DUF35_N PF12172.8 CCF45046.1 - 0.39 10.7 7.9 1.6 8.7 0.4 2.8 3 0 0 3 3 3 0 Rubredoxin-like zinc ribbon domain (DUF35_N) HABP4_PAI-RBP1 PF04774.15 CCF45049.1 - 0.085 13.7 2.9 0.15 12.9 2.9 1.5 1 1 0 1 1 1 0 Hyaluronan / mRNA binding family REPA_OB_2 PF16900.5 CCF45050.1 - 0.0079 16.1 0.1 0.015 15.2 0.1 1.4 1 0 0 1 1 1 1 Replication protein A OB domain Fis1_TPR_C PF14853.6 CCF45050.1 - 0.027 14.5 0.0 0.055 13.5 0.0 1.5 1 0 0 1 1 1 0 Fis1 C-terminal tetratricopeptide repeat HalOD2 PF18547.1 CCF45051.1 - 0.083 12.8 0.3 0.24 11.3 0.3 1.7 1 0 0 1 1 1 0 Halobacterial output domain 2 Neurochondrin PF05536.11 CCF45052.1 - 5.1e-46 157.3 0.2 6e-46 157.0 0.2 1.0 1 0 0 1 1 1 1 Neurochondrin adh_short PF00106.25 CCF45056.1 - 1.6e-15 57.1 0.5 1.8e-15 56.9 0.5 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF45056.1 - 1.8e-13 50.6 1.1 2.1e-13 50.4 1.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF45056.1 - 1.1e-07 31.9 0.1 1.3e-07 31.7 0.1 1.0 1 0 0 1 1 1 1 KR domain CHB_HEX_C_1 PF13290.6 CCF45056.1 - 0.025 14.6 0.0 0.061 13.3 0.0 1.6 2 0 0 2 2 2 0 Chitobiase/beta-hexosaminidase C-terminal domain Fibrillarin PF01269.17 CCF45056.1 - 0.051 12.7 0.0 0.058 12.5 0.0 1.1 1 0 0 1 1 1 0 Fibrillarin CVNH PF08881.10 CCF45057.1 - 0.0048 17.6 0.0 0.0065 17.1 0.0 1.3 1 0 0 1 1 1 1 CVNH domain F-box PF00646.33 CCF45059.1 - 0.069 13.0 0.1 17 5.4 0.1 2.3 2 0 0 2 2 2 0 F-box domain Sigma70_r3 PF04539.16 CCF45059.1 - 0.071 13.2 0.0 0.2 11.8 0.0 1.7 2 0 0 2 2 2 0 Sigma-70 region 3 Mito_carr PF00153.27 CCF45060.1 - 1.3e-10 41.0 0.0 1.5e-10 40.8 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial carrier protein GTP_EFTU PF00009.27 CCF45061.1 - 7.3e-39 133.3 0.2 8.6e-39 133.1 0.2 1.0 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 CCF45061.1 - 6.3e-05 23.0 0.1 0.0022 18.1 0.1 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 CCF45061.1 - 0.054 13.5 0.0 4.7 7.2 0.0 2.1 2 0 0 2 2 2 0 Dynamin family G-alpha PF00503.20 CCF45061.1 - 0.093 11.9 0.1 0.15 11.1 0.0 1.5 1 1 1 2 2 2 0 G-protein alpha subunit FtsK_SpoIIIE PF01580.18 CCF45061.1 - 0.11 11.8 0.1 0.71 9.2 0.1 1.9 2 0 0 2 2 2 0 FtsK/SpoIIIE family Polyoma_lg_T_C PF06431.11 CCF45061.1 - 0.15 10.9 0.0 0.19 10.6 0.0 1.1 1 0 0 1 1 1 0 Polyomavirus large T antigen C-terminus Phosphodiest PF01663.22 CCF45063.1 - 9.8e-92 308.3 0.4 1.3e-91 307.9 0.4 1.2 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 CCF45063.1 - 0.031 13.7 0.3 1.1 8.6 0.1 2.4 2 1 0 2 2 2 0 Sulfatase Dynactin_p22 PF07426.11 CCF45064.1 - 0.01 15.7 0.0 0.021 14.7 0.0 1.5 1 1 1 2 2 2 0 Dynactin subunit p22 SAP130_C PF16014.5 CCF45064.1 - 0.048 12.8 2.9 0.056 12.5 2.9 1.1 1 0 0 1 1 1 0 Histone deacetylase complex subunit SAP130 C-terminus Peptidase_S29 PF02907.15 CCF45066.1 - 0.17 11.6 0.0 0.24 11.1 0.0 1.2 1 0 0 1 1 1 0 Hepatitis C virus NS3 protease Ribosomal_S10 PF00338.22 CCF45068.1 - 1.7e-26 92.3 0.2 2e-26 92.1 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e Fibrillarin_2 PF10113.9 CCF45068.1 - 0.0067 15.1 0.0 0.0067 15.1 0.0 1.1 1 0 0 1 1 1 1 Fibrillarin-like archaeal protein NACHT PF05729.12 CCF45070.1 - 1.1e-05 25.5 0.0 2.9e-05 24.0 0.0 1.8 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 CCF45070.1 - 1.6e-05 25.4 0.0 4.9e-05 23.8 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 CCF45070.1 - 0.12 12.6 0.0 0.37 11.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain MFS_1 PF07690.16 CCF45072.1 - 3.5e-37 128.2 49.1 2.7e-36 125.2 48.3 2.1 2 0 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 CCF45072.1 - 1.4e-14 53.5 20.3 1.9e-14 53.1 20.3 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 CCF45072.1 - 3.2e-11 42.7 6.9 3.2e-11 42.7 6.9 2.6 2 1 0 2 2 2 1 Sugar (and other) transporter OATP PF03137.20 CCF45072.1 - 0.032 12.5 2.3 0.11 10.8 0.6 2.4 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family HEV_ORF1 PF02444.16 CCF45074.1 - 0.053 14.1 2.2 0.053 14.1 2.2 2.7 1 1 2 3 3 3 0 Hepatitis E virus ORF-2 (Putative capsid protein) HATPase_c_3 PF13589.6 CCF45076.1 - 0.04 13.8 0.1 0.15 11.8 0.1 2.0 2 0 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase EphA2_TM PF14575.6 CCF45076.1 - 0.046 14.6 2.4 2.3 9.2 2.4 2.4 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain NCE101 PF11654.8 CCF45076.1 - 0.18 11.5 0.0 0.48 10.2 0.0 1.7 2 0 0 2 2 2 0 Non-classical export protein 1 ANAPC_CDC26 PF10471.9 CCF45076.1 - 0.55 11.1 9.9 9.6 7.1 8.1 3.1 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 ALMT PF11744.8 CCF45076.1 - 1.7 7.4 3.9 1.6 7.5 0.6 2.1 2 1 1 3 3 3 0 Aluminium activated malate transporter Spt20 PF12090.8 CCF45076.1 - 3.2 7.3 13.0 5.9 6.4 13.0 1.4 1 0 0 1 1 1 0 Spt20 family Tub_N PF16322.5 CCF45076.1 - 8.5 6.7 12.5 20 5.5 4.3 2.7 2 1 0 2 2 2 0 Tubby N-terminal Pro_CA PF00484.19 CCF45077.1 - 7.6e-51 172.5 0.0 1e-50 172.0 0.0 1.2 1 0 0 1 1 1 1 Carbonic anhydrase Secretin_N_2 PF07655.13 CCF45081.1 - 0.91 10.1 12.3 1.9 9.1 12.3 1.4 1 0 0 1 1 1 0 Secretin N-terminal domain Fungal_trans_2 PF11951.8 CCF45082.1 - 6.1e-82 275.5 0.0 7.4e-82 275.2 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain FerI PF08151.12 CCF45082.1 - 0.073 13.2 0.0 0.18 11.9 0.0 1.6 1 0 0 1 1 1 0 FerI (NUC094) domain DASH_Spc19 PF08287.11 CCF45083.1 - 5e-29 101.2 0.0 5.3e-29 101.1 0.0 1.0 1 0 0 1 1 1 1 Spc19 Fungal_trans_2 PF11951.8 CCF45086.1 - 0.00016 20.6 0.1 0.00024 20.0 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Thi4 PF01946.17 CCF45087.1 - 3.6e-117 389.7 0.2 4.2e-117 389.4 0.2 1.0 1 0 0 1 1 1 1 Thi4 family DAO PF01266.24 CCF45087.1 - 2.9e-07 30.4 3.7 9.9e-07 28.6 2.2 2.0 1 1 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CCF45087.1 - 5.1e-05 23.4 0.4 0.00012 22.2 0.4 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 CCF45087.1 - 0.0002 20.6 2.3 0.00046 19.3 0.6 2.1 3 0 0 3 3 3 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 CCF45087.1 - 0.00038 19.8 0.1 0.00052 19.3 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CCF45087.1 - 0.00049 19.3 4.6 0.0067 15.6 1.1 2.6 2 1 1 3 3 3 1 FAD binding domain NAD_binding_9 PF13454.6 CCF45087.1 - 0.0029 17.6 0.1 0.0029 17.6 0.1 2.0 3 0 0 3 3 3 1 FAD-NAD(P)-binding FAD_binding_3 PF01494.19 CCF45087.1 - 0.011 15.0 0.0 0.017 14.4 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain FAD_oxidored PF12831.7 CCF45087.1 - 0.046 13.1 0.2 0.071 12.4 0.2 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 CCF45087.1 - 0.061 12.6 0.0 0.096 11.9 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase ATG16 PF08614.11 CCF45089.1 - 0.00034 20.9 2.0 0.00035 20.8 0.1 1.7 1 1 0 2 2 2 1 Autophagy protein 16 (ATG16) Macoilin PF09726.9 CCF45089.1 - 0.073 11.6 0.5 0.087 11.4 0.5 1.0 1 0 0 1 1 1 0 Macoilin family LPP PF04728.13 CCF45089.1 - 0.18 12.2 1.5 1.7 9.1 1.5 2.2 1 1 0 1 1 1 0 Lipoprotein leucine-zipper SOG2 PF10428.9 CCF45089.1 - 1.8 7.7 9.0 2.2 7.4 9.0 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein XPG_I PF00867.18 CCF45091.1 - 0.087 13.2 0.0 0.11 12.8 0.0 1.3 1 1 0 1 1 1 0 XPG I-region SelP_N PF04592.14 CCF45091.1 - 3.5 7.0 12.8 4 6.8 12.8 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region KASH PF10541.9 CCF45092.1 - 0.051 13.8 4.0 0.079 13.2 4.0 1.3 1 0 0 1 1 1 0 Nuclear envelope localisation domain DUF3675 PF12428.8 CCF45092.1 - 0.07 13.7 0.4 0.071 13.7 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3675) DDE_1 PF03184.19 CCF45093.1 - 2.6e-36 124.9 0.0 5.9e-36 123.7 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_psq PF05225.16 CCF45093.1 - 5.2e-11 42.1 0.1 1e-10 41.2 0.1 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.16 CCF45093.1 - 2.3e-10 40.4 0.2 6.8e-10 38.8 0.0 1.9 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain DDE_3 PF13358.6 CCF45093.1 - 5e-05 23.1 0.0 0.00012 21.8 0.0 1.7 1 1 1 2 2 2 1 DDE superfamily endonuclease HTH_23 PF13384.6 CCF45093.1 - 0.00078 19.2 0.1 0.0022 17.7 0.1 1.8 1 0 0 1 1 1 1 Homeodomain-like domain HTH_7 PF02796.15 CCF45093.1 - 0.0035 17.4 0.1 0.0078 16.3 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_30 PF13556.6 CCF45093.1 - 0.013 15.3 0.1 0.027 14.3 0.1 1.5 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain HTH_28 PF13518.6 CCF45093.1 - 0.029 14.5 0.1 0.083 13.0 0.1 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_Tnp_1 PF01527.20 CCF45093.1 - 0.098 13.0 0.2 0.2 12.0 0.2 1.6 1 0 0 1 1 1 0 Transposase HTH_1 PF00126.27 CCF45093.1 - 0.15 12.0 0.5 0.35 10.9 0.5 1.6 1 0 0 1 1 1 0 Bacterial regulatory helix-turn-helix protein, lysR family Complex1_LYR PF05347.15 CCF45094.1 - 1.4e-08 34.6 0.0 2.4e-08 33.9 0.0 1.4 1 0 0 1 1 1 1 Complex 1 protein (LYR family) DUF4018 PF13210.6 CCF45094.1 - 0.11 12.3 0.0 0.13 12.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4018) GOLD_2 PF13897.6 CCF45095.1 - 0.21 12.1 2.0 0.26 11.8 0.3 1.9 2 0 0 2 2 2 0 Golgi-dynamics membrane-trafficking PBP1_TM PF14812.6 CCF45095.1 - 1.5 9.2 5.9 1.2 9.6 1.8 2.3 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal RNase_H PF00075.24 CCF45096.1 - 5.7e-37 127.1 0.2 9.7e-37 126.3 0.2 1.4 1 0 0 1 1 1 1 RNase H Cauli_VI PF01693.16 CCF45096.1 - 1.3e-33 115.0 11.6 1.7e-20 73.1 1.1 2.7 3 0 0 3 3 3 2 Caulimovirus viroplasmin GARS_A PF01071.19 CCF45096.1 - 0.069 12.9 0.1 0.67 9.7 0.0 2.1 2 0 0 2 2 2 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Telomerase_RBD PF12009.8 CCF45097.1 - 1.9e-50 170.4 0.2 4.1e-50 169.4 0.2 1.6 1 0 0 1 1 1 1 Telomerase ribonucleoprotein complex - RNA binding domain RVT_1 PF00078.27 CCF45097.1 - 7.8e-16 58.3 0.0 1.9e-11 43.9 0.0 2.5 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1810 PF08837.11 CCF45097.1 - 0.14 11.9 0.0 12 5.6 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1810) DEAD PF00270.29 CCF45100.1 - 7.6e-30 104.0 0.0 1.2e-29 103.4 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF45100.1 - 6.4e-20 71.6 0.1 6.1e-19 68.4 0.1 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCF45100.1 - 1.5e-05 25.1 0.0 6.2e-05 23.1 0.0 2.0 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit ketoacyl-synt PF00109.26 CCF45102.1 - 3.2e-41 141.6 0.3 3.3e-33 115.3 0.1 2.4 1 1 1 2 2 2 2 Beta-ketoacyl synthase, N-terminal domain SAT PF16073.5 CCF45102.1 - 1e-08 35.2 0.1 2.1e-08 34.2 0.1 1.6 1 0 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Insulin_TMD PF17870.1 CCF45104.1 - 0.77 9.9 4.5 0.6 10.2 0.3 2.5 3 0 0 3 3 3 0 Insulin receptor trans-membrane segment STb_secrete PF09075.10 CCF45104.1 - 0.86 9.7 4.5 13 6.0 0.3 2.3 1 1 1 2 2 2 0 Heat-stable enterotoxin B, secretory Ribosomal_S5_C PF03719.15 CCF45105.1 - 3.5e-20 71.2 0.1 3.3e-19 68.1 0.0 2.4 2 0 0 2 2 2 1 Ribosomal protein S5, C-terminal domain Ribosomal_S5 PF00333.20 CCF45105.1 - 3.4e-17 62.2 0.6 7.8e-17 61.0 0.6 1.6 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Thymidylat_synt PF00303.19 CCF45105.1 - 0.11 11.6 0.1 0.17 11.0 0.1 1.2 1 0 0 1 1 1 0 Thymidylate synthase RWD PF05773.22 CCF45106.1 - 2.5e-18 66.5 0.0 3.8e-18 65.9 0.0 1.3 1 0 0 1 1 1 1 RWD domain zf-RING_2 PF13639.6 CCF45106.1 - 6.6e-05 23.2 7.6 0.00011 22.5 7.6 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 CCF45106.1 - 0.00029 20.8 6.0 0.00055 19.9 6.0 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 CCF45106.1 - 0.0011 18.8 8.2 0.0018 18.1 8.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CCF45106.1 - 0.0019 18.1 8.1 0.0038 17.2 8.1 1.6 1 1 0 1 1 1 1 zinc-RING finger domain zf-RING_11 PF17123.5 CCF45106.1 - 0.0023 17.6 8.7 0.0058 16.4 8.7 1.8 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 CCF45106.1 - 0.034 14.0 6.4 0.063 13.1 6.4 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 CCF45106.1 - 0.038 14.2 7.4 0.13 12.4 7.4 2.0 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 CCF45106.1 - 0.62 10.0 6.4 2.5 8.1 6.4 2.0 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 IBR PF01485.21 CCF45106.1 - 1.4 9.2 9.5 2 8.7 4.7 2.5 2 1 1 3 3 3 0 IBR domain, a half RING-finger domain PRP1_N PF06424.12 CCF45109.1 - 4.6e-53 179.6 9.6 1.1e-52 178.4 9.6 1.7 1 0 0 1 1 1 1 PRP1 splicing factor, N-terminal TPR_14 PF13428.6 CCF45109.1 - 2.7e-29 99.3 35.0 0.0005 20.7 0.3 14.1 4 3 12 16 16 15 9 Tetratricopeptide repeat TPR_19 PF14559.6 CCF45109.1 - 4.7e-29 100.7 13.1 4.1e-07 30.4 0.4 10.2 5 3 4 10 10 10 7 Tetratricopeptide repeat TPR_16 PF13432.6 CCF45109.1 - 3.8e-19 69.0 16.6 1.1e-06 29.1 0.8 8.2 7 2 2 9 9 8 3 Tetratricopeptide repeat TPR_2 PF07719.17 CCF45109.1 - 1.2e-15 56.2 7.9 0.24 11.6 0.0 10.7 11 1 1 12 12 10 2 Tetratricopeptide repeat TPR_8 PF13181.6 CCF45109.1 - 4.4e-12 45.2 1.0 0.095 13.0 0.0 8.1 10 0 0 10 10 8 3 Tetratricopeptide repeat TPR_17 PF13431.6 CCF45109.1 - 1e-11 44.3 5.0 0.7 10.4 0.0 9.0 8 2 1 9 9 8 1 Tetratricopeptide repeat NARP1 PF12569.8 CCF45109.1 - 3.1e-08 33.0 11.7 0.16 10.9 0.0 6.1 4 2 2 6 6 6 3 NMDA receptor-regulated protein 1 TPR_9 PF13371.6 CCF45109.1 - 3.5e-08 33.5 7.8 0.0032 17.6 0.0 6.5 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_15 PF13429.6 CCF45109.1 - 1.7e-07 30.7 27.4 6.8e-05 22.2 5.5 6.8 3 2 3 7 7 7 3 Tetratricopeptide repeat TPR_1 PF00515.28 CCF45109.1 - 1.2e-06 28.0 0.2 0.88 9.5 0.0 5.7 6 0 0 6 6 5 2 Tetratricopeptide repeat Wzy_C_2 PF11846.8 CCF45109.1 - 6.9e-05 22.9 2.0 0.72 9.7 0.1 4.1 3 1 1 4 4 4 2 Virulence factor membrane-bound polymerase, C-terminal Suf PF05843.14 CCF45109.1 - 0.0001 22.4 0.3 4.3 7.2 0.0 4.7 4 1 0 5 5 5 1 Suppressor of forked protein (Suf) TPR_6 PF13174.6 CCF45109.1 - 0.00037 21.0 11.0 12 6.8 0.1 8.7 10 0 0 10 10 8 0 Tetratricopeptide repeat ANAPC3 PF12895.7 CCF45109.1 - 0.00042 20.5 0.6 3.1 8.1 0.0 4.4 3 1 1 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_21 PF09976.9 CCF45109.1 - 0.00056 19.7 18.3 0.014 15.1 1.0 5.0 3 2 2 5 5 5 2 Tetratricopeptide repeat-like domain TPR_11 PF13414.6 CCF45109.1 - 0.029 14.1 13.9 4.9 6.9 0.0 6.6 7 1 1 8 8 8 0 TPR repeat DUF3808 PF10300.9 CCF45109.1 - 0.081 11.7 1.3 12 4.5 0.1 3.9 4 1 2 6 6 6 0 Protein of unknown function (DUF3808) CREPT PF16566.5 CCF45109.1 - 0.14 12.3 3.5 2 8.6 0.4 2.7 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour TPR_7 PF13176.6 CCF45109.1 - 0.18 11.9 2.1 7.5 6.8 0.0 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat ChAPs PF09295.10 CCF45109.1 - 0.66 8.9 5.9 4.5 6.2 0.3 3.2 2 1 0 3 3 3 0 ChAPs (Chs5p-Arf1p-binding proteins) Apolipoprotein PF01442.18 CCF45110.1 - 0.0045 16.9 2.2 0.0099 15.8 2.2 1.6 1 1 0 1 1 1 1 Apolipoprotein A1/A4/E domain BshC PF10079.9 CCF45110.1 - 0.16 10.7 0.8 0.17 10.6 0.8 1.1 1 0 0 1 1 1 0 Bacillithiol biosynthesis BshC Pro_Al_protease PF02983.14 CCF45110.1 - 0.58 10.2 8.3 2.1 8.4 3.5 2.7 1 1 1 2 2 2 0 Alpha-lytic protease prodomain Remorin_C PF03763.13 CCF45110.1 - 0.6 10.0 9.0 0.44 10.4 6.2 1.8 1 1 1 2 2 2 0 Remorin, C-terminal region LXG PF04740.12 CCF45111.1 - 0.047 13.4 0.5 0.081 12.6 0.5 1.4 1 0 0 1 1 1 0 LXG domain of WXG superfamily PPR_2 PF13041.6 CCF45112.1 - 0.00039 20.5 0.0 0.099 12.9 0.0 2.8 2 0 0 2 2 2 2 PPR repeat family PPR_3 PF13812.6 CCF45112.1 - 0.014 15.4 0.1 0.48 10.5 0.0 2.7 3 0 0 3 3 3 0 Pentatricopeptide repeat domain KH_1 PF00013.29 CCF45112.1 - 0.04 13.8 0.0 0.085 12.7 0.0 1.6 1 0 0 1 1 1 0 KH domain MARVEL PF01284.23 CCF45116.1 - 0.41 10.7 16.6 0.77 9.8 16.5 1.5 1 1 0 1 1 1 0 Membrane-associating domain Inositol_P PF00459.25 CCF45117.1 - 7.5e-39 133.9 0.0 8.4e-39 133.7 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family ArfA PF03889.13 CCF45117.1 - 0.09 12.3 0.1 0.14 11.7 0.1 1.3 1 0 0 1 1 1 0 Alternative ribosome-rescue factor A Methyltransf_16 PF10294.9 CCF45119.1 - 1e-09 38.4 0.0 0.0014 18.4 0.0 2.1 2 0 0 2 2 2 2 Lysine methyltransferase Aconitase_C PF00694.19 CCF45120.1 - 8.1e-33 113.5 0.0 1.3e-32 112.9 0.0 1.3 1 0 0 1 1 1 1 Aconitase C-terminal domain Aconitase_2_N PF06434.13 CCF45120.1 - 0.025 14.2 0.1 0.13 11.8 0.1 1.9 1 1 0 1 1 1 0 Aconitate hydratase 2 N-terminus DUF1977 PF09320.11 CCF45121.1 - 3e-28 98.1 0.0 4.1e-28 97.7 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1977) UPRTase PF14681.6 CCF45122.1 - 2.1e-32 112.3 0.0 3.7e-32 111.4 0.0 1.4 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase HAD PF12710.7 CCF45122.1 - 1.7e-14 54.7 0.1 2.6e-14 54.1 0.1 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Pribosyltran PF00156.27 CCF45122.1 - 2.7e-05 23.8 1.5 0.01 15.4 0.7 2.4 1 1 1 2 2 2 2 Phosphoribosyl transferase domain Hydrolase PF00702.26 CCF45122.1 - 2.7e-05 24.6 0.0 4.6e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase PRTase_2 PF15609.6 CCF45122.1 - 0.019 14.4 0.3 0.054 13.0 0.0 1.9 2 0 0 2 2 2 0 Phosphoribosyl transferase Hydrolase_3 PF08282.12 CCF45122.1 - 0.14 11.9 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase DUF423 PF04241.15 CCF45124.1 - 0.0035 17.5 0.1 0.0074 16.5 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF423) Ecm29 PF13001.7 CCF45125.1 - 3.4e-07 29.3 0.2 3.8e-07 29.2 0.2 1.0 1 0 0 1 1 1 1 Proteasome stabiliser Fructosamin_kin PF03881.14 CCF45127.1 - 6.7e-73 245.4 0.0 7.8e-73 245.2 0.0 1.0 1 0 0 1 1 1 1 Fructosamine kinase APH PF01636.23 CCF45127.1 - 0.0033 17.4 0.0 0.006 16.5 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.11 CCF45127.1 - 0.0076 15.2 0.0 0.011 14.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) RHD3 PF05879.12 CCF45128.1 - 0 1050.1 0.0 0 1049.8 0.0 1.0 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) GBP PF02263.19 CCF45128.1 - 3.9e-09 36.2 0.3 6.4e-09 35.4 0.3 1.2 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain Dynamin_N PF00350.23 CCF45128.1 - 4.9e-07 29.9 0.0 9.8e-07 29.0 0.0 1.5 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 CCF45128.1 - 0.0001 22.4 0.0 0.00021 21.3 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_28 PF13521.6 CCF45128.1 - 0.00026 21.2 0.0 0.0016 18.7 0.0 2.4 1 0 0 1 1 1 1 AAA domain Septin PF00735.18 CCF45128.1 - 0.042 13.1 0.1 0.069 12.4 0.1 1.3 1 0 0 1 1 1 0 Septin RsgA_GTPase PF03193.16 CCF45128.1 - 0.17 11.8 0.1 0.33 10.8 0.1 1.4 1 0 0 1 1 1 0 RsgA GTPase PLU-1 PF08429.11 CCF45129.1 - 0.033 13.4 0.0 0.042 13.0 0.0 1.1 1 0 0 1 1 1 0 PLU-1-like protein Arg_decarbox_C PF17944.1 CCF45129.1 - 0.081 13.5 0.0 0.14 12.7 0.0 1.4 1 0 0 1 1 1 0 Arginine decarboxylase C-terminal helical extension DDE_1 PF03184.19 CCF45131.1 - 2.6e-30 105.4 0.0 5.2e-30 104.4 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_psq PF05225.16 CCF45131.1 - 2e-10 40.2 0.1 3.8e-10 39.3 0.1 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.16 CCF45131.1 - 1.1e-09 38.2 0.0 2.5e-09 37.0 0.0 1.6 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain ABC_tran PF00005.27 CCF45132.1 - 4.3e-47 160.1 0.0 2.2e-25 89.8 0.0 2.4 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 CCF45132.1 - 3.6e-33 115.4 37.1 4.1e-29 102.1 14.6 2.4 2 0 0 2 2 2 2 ABC transporter transmembrane region AAA_21 PF13304.6 CCF45132.1 - 1e-12 48.5 2.6 0.00028 20.8 0.1 4.5 3 1 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CCF45132.1 - 1.3e-11 44.4 1.1 0.0038 16.7 0.1 3.9 2 2 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CCF45132.1 - 8.1e-08 33.0 0.0 0.00098 19.7 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.6 CCF45132.1 - 5.3e-07 29.3 0.3 0.021 14.6 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CCF45132.1 - 2.1e-06 27.8 0.4 0.063 13.2 0.1 2.4 2 0 0 2 2 2 2 RsgA GTPase T2SSE PF00437.20 CCF45132.1 - 2.4e-05 23.5 0.0 0.03 13.4 0.0 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_15 PF13175.6 CCF45132.1 - 2.7e-05 24.0 0.1 0.053 13.2 0.0 2.2 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 CCF45132.1 - 0.00015 22.0 1.1 0.57 10.5 0.0 3.4 3 0 0 3 3 3 2 AAA domain MMR_HSR1 PF01926.23 CCF45132.1 - 0.0003 20.8 1.0 0.31 11.1 0.1 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase NB-ARC PF00931.22 CCF45132.1 - 0.00035 19.9 0.2 0.0094 15.2 0.0 2.4 2 0 0 2 2 2 1 NB-ARC domain Dynamin_N PF00350.23 CCF45132.1 - 0.00067 19.8 1.8 0.65 10.0 0.1 2.6 2 0 0 2 2 2 2 Dynamin family AAA_7 PF12775.7 CCF45132.1 - 0.00095 18.7 0.1 1.2 8.6 0.0 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_16 PF13191.6 CCF45132.1 - 0.0019 18.6 0.1 0.63 10.4 0.0 2.8 2 0 0 2 2 2 1 AAA ATPase domain Rad17 PF03215.15 CCF45132.1 - 0.011 15.7 0.0 0.025 14.5 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_25 PF13481.6 CCF45132.1 - 0.011 15.3 0.0 0.84 9.2 0.0 2.5 2 0 0 2 2 2 0 AAA domain TrwB_AAD_bind PF10412.9 CCF45132.1 - 0.015 14.2 0.4 1.7 7.5 0.0 2.4 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain FtsK_SpoIIIE PF01580.18 CCF45132.1 - 0.017 14.5 0.8 0.46 9.8 0.0 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family DUF87 PF01935.17 CCF45132.1 - 0.017 15.2 0.8 0.27 11.3 0.1 2.3 2 0 0 2 2 2 0 Helicase HerA, central domain IstB_IS21 PF01695.17 CCF45132.1 - 0.022 14.5 0.2 12 5.6 0.0 2.9 3 0 0 3 3 3 0 IstB-like ATP binding protein Adeno_IVa2 PF02456.15 CCF45132.1 - 0.026 13.4 0.4 0.3 9.8 0.1 2.1 2 0 0 2 2 2 0 Adenovirus IVa2 protein Mg_chelatase PF01078.21 CCF45132.1 - 0.028 13.8 0.0 3.7 6.9 0.0 2.4 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_30 PF13604.6 CCF45132.1 - 0.038 13.7 0.0 1.4 8.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_27 PF13514.6 CCF45132.1 - 0.045 13.3 0.0 0.15 11.6 0.0 1.8 2 0 0 2 2 1 0 AAA domain ATPase_2 PF01637.18 CCF45132.1 - 0.046 13.6 0.1 0.76 9.7 0.0 2.2 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea cobW PF02492.19 CCF45132.1 - 0.048 13.3 1.6 3.3 7.3 0.3 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.6 CCF45132.1 - 0.065 13.8 0.0 8.8 6.9 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 CCF45132.1 - 0.069 13.6 0.1 0.35 11.3 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Viral_helicase1 PF01443.18 CCF45132.1 - 0.09 12.5 0.2 3.3 7.4 0.1 2.3 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase RNA_helicase PF00910.22 CCF45132.1 - 0.099 13.0 0.0 10 6.6 0.0 2.7 2 0 0 2 2 2 0 RNA helicase NACHT PF05729.12 CCF45132.1 - 0.099 12.6 0.8 13 5.7 0.2 2.5 2 0 0 2 2 2 0 NACHT domain DUF815 PF05673.13 CCF45132.1 - 0.12 11.5 0.1 10 5.2 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) PduV-EutP PF10662.9 CCF45132.1 - 0.2 11.4 0.4 18 5.1 0.0 3.2 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation Ribosomal_L28e PF01778.17 CCF45133.1 - 7.1e-18 65.4 0.6 9.9e-18 65.0 0.2 1.3 1 1 0 1 1 1 1 Ribosomal L28e protein family Potassium_chann PF11404.8 CCF45133.1 - 9.7 6.1 6.1 15 5.5 0.2 2.6 2 1 0 2 2 2 0 Potassium voltage-gated channel Amino_oxidase PF01593.24 CCF45138.1 - 1e-10 41.5 0.0 1.9e-10 40.6 0.0 1.4 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CCF45138.1 - 3.2e-08 33.7 0.2 8.8e-08 32.3 0.2 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 CCF45138.1 - 0.00053 19.5 0.7 0.0011 18.5 0.3 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CCF45138.1 - 0.0015 17.7 1.7 0.0024 17.0 1.7 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 CCF45138.1 - 0.016 14.4 0.1 0.027 13.7 0.1 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CCF45138.1 - 0.03 13.0 0.4 0.046 12.4 0.4 1.1 1 0 0 1 1 1 0 HI0933-like protein Pyr_redox_2 PF07992.14 CCF45138.1 - 0.062 12.5 0.1 0.11 11.7 0.1 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCF45138.1 - 0.1 12.1 1.3 0.27 10.8 0.7 1.8 2 0 0 2 2 2 0 FAD dependent oxidoreductase DUF3328 PF11807.8 CCF45139.1 - 4.6e-15 56.0 0.1 5.8e-15 55.7 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) UBA PF00627.31 CCF45140.1 - 2.2e-07 30.6 0.1 4.1e-07 29.8 0.1 1.4 1 0 0 1 1 1 1 UBA/TS-N domain SAT PF16073.5 CCF45141.1 - 6.8e-77 258.4 0.2 2.2e-76 256.8 0.1 2.0 2 0 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis ketoacyl-synt PF00109.26 CCF45141.1 - 2e-74 250.4 0.0 4.7e-74 249.2 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 CCF45141.1 - 2.6e-45 155.3 0.0 5e-45 154.4 0.0 1.5 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 CCF45141.1 - 2e-36 124.6 0.5 4.8e-36 123.4 0.5 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Thioesterase PF00975.20 CCF45141.1 - 3.7e-23 82.9 0.0 2.2e-22 80.3 0.0 2.4 2 1 0 2 2 2 1 Thioesterase domain PP-binding PF00550.25 CCF45141.1 - 1.9e-22 79.4 3.9 2.2e-11 44.0 0.2 2.7 2 0 0 2 2 2 2 Phosphopantetheine attachment site PS-DH PF14765.6 CCF45141.1 - 8.7e-20 71.1 0.0 1.6e-19 70.3 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase KAsynt_C_assoc PF16197.5 CCF45141.1 - 2.7e-05 24.6 0.0 6.6e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Thiolase_N PF00108.23 CCF45141.1 - 0.00023 20.6 0.1 0.0011 18.4 0.0 2.1 2 0 0 2 2 2 1 Thiolase, N-terminal domain Hydrolase_4 PF12146.8 CCF45141.1 - 0.0093 15.3 0.3 0.15 11.3 0.0 2.5 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Ribosomal_60s PF00428.19 CCF45141.1 - 0.36 11.5 10.6 0.86 10.2 7.0 2.8 2 0 0 2 2 2 0 60s Acidic ribosomal protein JAB PF01398.21 CCF45142.1 - 1.3e-28 99.4 0.1 1.6e-28 99.0 0.1 1.1 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.6 CCF45142.1 - 6.3e-05 22.7 0.0 9.2e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain UPF0172 PF03665.13 CCF45142.1 - 0.047 13.7 0.0 0.068 13.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0172) RCR PF12273.8 CCF45145.1 - 0.00086 20.0 0.9 0.0015 19.2 0.9 1.4 1 1 0 1 1 1 1 Chitin synthesis regulation, resistance to Congo red SARAF PF06682.12 CCF45145.1 - 0.0022 17.7 0.0 0.0026 17.5 0.0 1.1 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis EphA2_TM PF14575.6 CCF45145.1 - 0.069 14.0 0.0 0.082 13.8 0.0 1.2 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain WBP-1 PF11669.8 CCF45145.1 - 0.074 13.7 4.5 0.15 12.7 4.5 1.6 1 1 0 1 1 1 0 WW domain-binding protein 1 Sensor PF13796.6 CCF45145.1 - 0.084 12.9 0.0 0.11 12.5 0.0 1.2 1 0 0 1 1 1 0 Putative sensor Baculo_F PF12259.8 CCF45145.1 - 0.14 10.6 0.1 0.18 10.3 0.1 1.0 1 0 0 1 1 1 0 Baculovirus F protein MIG-14_Wnt-bd PF06664.12 CCF45145.1 - 0.15 11.3 0.0 0.19 10.9 0.0 1.0 1 0 0 1 1 1 0 Wnt-binding factor required for Wnt secretion LST1 PF05083.13 CCF45145.1 - 0.25 11.6 0.8 0.43 10.9 0.8 1.4 1 0 0 1 1 1 0 LST-1 protein PROL5-SMR PF15621.6 CCF45145.1 - 0.48 11.0 6.4 1.1 9.8 6.4 1.5 1 1 0 1 1 1 0 Proline-rich submaxillary gland androgen-regulated family Synaptobrevin PF00957.21 CCF45145.1 - 0.54 10.1 3.7 0.82 9.5 3.7 1.2 1 0 0 1 1 1 0 Synaptobrevin APOBEC_C PF05240.14 CCF45147.1 - 0.19 11.7 0.0 0.26 11.3 0.0 1.2 1 0 0 1 1 1 0 APOBEC-like C-terminal domain Enolase_C PF00113.22 CCF45150.1 - 6.4e-150 498.4 0.2 8.2e-150 498.0 0.2 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 CCF45150.1 - 1.9e-57 193.0 0.1 4e-57 192.0 0.1 1.6 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 CCF45150.1 - 7.8e-06 25.6 0.0 1.4e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 CCF45150.1 - 0.0033 16.6 0.3 0.067 12.3 0.1 2.3 2 0 0 2 2 2 1 Methylaspartate ammonia-lyase C-terminus Pec_lyase_C PF00544.19 CCF45151.1 - 3.9e-40 137.7 9.3 4.7e-40 137.4 9.3 1.1 1 0 0 1 1 1 1 Pectate lyase Beta_helix PF13229.6 CCF45151.1 - 0.0011 18.8 10.8 0.0029 17.5 10.8 1.7 1 1 0 1 1 1 1 Right handed beta helix region MFS_1 PF07690.16 CCF45152.1 - 3.9e-27 95.1 18.3 3.9e-27 95.1 18.3 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily Glycos_transf_2 PF00535.26 CCF45155.1 - 9.1e-25 87.4 0.0 1.5e-24 86.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 CCF45155.1 - 4.9e-09 36.4 0.0 5.2e-07 29.8 0.0 2.3 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 CCF45155.1 - 0.0023 18.4 0.0 0.0045 17.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.9 CCF45155.1 - 0.0033 16.9 0.0 0.0067 15.9 0.0 1.4 2 0 0 2 2 2 1 Glycosyltransferase like family 2 DUF1518 PF07469.12 CCF45155.1 - 0.19 12.1 0.4 0.36 11.3 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1518) DND1_DSRM PF14709.7 CCF45156.1 - 0.00058 20.1 0.1 0.0011 19.2 0.1 1.6 1 1 0 1 1 1 1 double strand RNA binding domain from DEAD END PROTEIN 1 dsrm PF00035.26 CCF45156.1 - 0.0051 17.5 0.0 0.011 16.4 0.0 1.6 1 0 0 1 1 1 1 Double-stranded RNA binding motif bZIP_1 PF00170.21 CCF45157.1 - 0.33 11.1 7.0 1.8 8.7 5.8 2.2 1 1 1 2 2 2 0 bZIP transcription factor Glyco_hydro_3_C PF01915.22 CCF45158.1 - 3.4e-65 219.8 0.0 6.8e-65 218.8 0.0 1.5 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 CCF45158.1 - 2e-24 85.5 2.0 1.1e-23 83.1 0.5 2.3 2 0 0 2 2 2 1 Fibronectin type III-like domain PA14 PF07691.12 CCF45158.1 - 6.1e-18 65.0 0.0 1.2e-17 64.1 0.0 1.6 1 0 0 1 1 1 1 PA14 domain Lipase_GDSL_2 PF13472.6 CCF45158.1 - 0.034 14.5 0.1 0.065 13.6 0.1 1.4 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family MitMem_reg PF13012.6 CCF45160.1 - 5.7e-16 58.9 0.0 7.7e-16 58.5 0.0 1.2 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function tRNA_bind_2 PF13725.6 CCF45160.1 - 0.0029 17.4 5.6 0.0034 17.1 5.6 1.1 1 0 0 1 1 1 1 Possible tRNA binding domain Abhydrolase_3 PF07859.13 CCF45160.1 - 0.083 12.7 0.0 0.11 12.4 0.0 1.1 1 0 0 1 1 1 0 alpha/beta hydrolase fold Connexin PF00029.19 CCF45160.1 - 0.095 12.5 3.3 0.12 12.1 3.3 1.1 1 0 0 1 1 1 0 Connexin DUF809 PF05663.11 CCF45160.1 - 0.64 10.2 5.3 0.82 9.8 5.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF809) O-antigen_lig PF13425.6 CCF45160.1 - 2 7.1 4.3 2.3 6.9 4.3 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Presenilin PF01080.17 CCF45160.1 - 4.5 5.9 4.7 5 5.8 4.7 1.0 1 0 0 1 1 1 0 Presenilin SWIM PF04434.17 CCF45161.1 - 0.0039 16.8 0.5 0.35 10.6 0.1 2.3 2 0 0 2 2 2 2 SWIM zinc finger Coprogen_oxidas PF01218.18 CCF45162.1 - 1e-44 152.4 0.0 1.2e-44 152.3 0.0 1.0 1 0 0 1 1 1 1 Coproporphyrinogen III oxidase DUF1651 PF07864.11 CCF45162.1 - 0.00098 19.4 0.1 0.078 13.3 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF1651) Kelch_5 PF13854.6 CCF45163.1 - 5.3e-15 55.0 7.0 1.5e-06 28.1 0.0 4.8 4 1 0 4 4 4 4 Kelch motif Kelch_3 PF13415.6 CCF45163.1 - 1.5e-09 37.9 8.3 0.00046 20.4 0.0 4.9 4 1 0 4 4 4 4 Galactose oxidase, central domain Kelch_6 PF13964.6 CCF45163.1 - 3.8e-09 36.5 3.4 0.031 14.6 0.0 5.0 5 0 0 5 5 5 3 Kelch motif Kelch_4 PF13418.6 CCF45163.1 - 3.7e-08 33.2 7.7 0.19 11.8 0.0 5.6 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_1 PF01344.25 CCF45163.1 - 0.00012 21.6 2.6 8 6.1 0.2 4.5 4 0 0 4 4 4 2 Kelch motif CDC45 PF02724.14 CCF45163.1 - 0.018 13.4 1.6 0.023 13.0 1.6 1.1 1 0 0 1 1 1 0 CDC45-like protein Kelch_2 PF07646.15 CCF45163.1 - 0.25 11.4 5.3 5.3 7.2 0.1 4.3 6 0 0 6 6 6 0 Kelch motif Nop14 PF04147.12 CCF45163.1 - 2.9 6.0 8.7 4.1 5.5 8.7 1.2 1 0 0 1 1 1 0 Nop14-like family NOA36 PF06524.12 CCF45163.1 - 7.9 5.7 11.7 12 5.1 11.7 1.2 1 0 0 1 1 1 0 NOA36 protein Amidohydro_1 PF01979.20 CCF45164.1 - 2.7e-70 237.4 0.0 3.3e-70 237.1 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 CCF45164.1 - 1.3e-09 38.1 1.8 2.2e-07 30.7 0.1 2.3 2 0 0 2 2 2 2 Amidohydrolase family tRNA_int_end_N2 PF12928.7 CCF45164.1 - 0.093 12.9 0.0 0.21 11.8 0.0 1.6 1 0 0 1 1 1 0 tRNA-splicing endonuclease subunit sen54 N-term Ank_2 PF12796.7 CCF45165.1 - 3.2e-49 165.5 0.2 1.1e-15 58.0 0.1 5.9 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank PF00023.30 CCF45165.1 - 2.2e-36 122.7 0.7 6e-05 23.3 0.0 9.2 9 0 0 9 9 9 8 Ankyrin repeat Ank_4 PF13637.6 CCF45165.1 - 1.7e-33 114.5 0.2 3.4e-06 27.5 0.0 5.6 3 2 1 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCF45165.1 - 1.3e-30 102.0 0.0 0.0017 18.7 0.0 9.3 9 0 0 9 9 9 8 Ankyrin repeat Ank_5 PF13857.6 CCF45165.1 - 1.4e-30 104.9 3.2 3.3e-06 27.3 0.0 7.2 3 2 6 9 9 9 7 Ankyrin repeats (many copies) C1_2 PF03107.16 CCF45165.1 - 0.0089 16.3 3.1 0.02 15.2 3.1 1.6 1 0 0 1 1 1 1 C1 domain zf-UBR PF02207.20 CCF45165.1 - 0.012 15.7 1.3 0.024 14.8 1.3 1.5 1 0 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) ZZ PF00569.17 CCF45165.1 - 0.49 10.2 7.8 1 9.2 7.8 1.4 1 0 0 1 1 1 0 Zinc finger, ZZ type Cupin_2 PF07883.11 CCF45166.1 - 2.6e-08 33.5 0.0 4.4e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 CCF45166.1 - 0.034 13.8 0.0 0.055 13.1 0.0 1.3 1 0 0 1 1 1 0 Cupin Cupin_6 PF12852.7 CCF45166.1 - 0.073 12.8 0.0 0.09 12.5 0.0 1.3 1 0 0 1 1 1 0 Cupin Abhydrolase_6 PF12697.7 CCF45167.1 - 0.0019 18.8 2.4 0.0019 18.8 2.4 2.1 2 1 1 3 3 3 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CCF45167.1 - 0.029 14.0 0.0 0.055 13.1 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Ser_hydrolase PF06821.13 CCF45167.1 - 0.11 12.4 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase Abhydrolase_8 PF06259.12 CCF45167.1 - 0.18 11.4 0.0 0.37 10.4 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase TrbC PF04956.13 CCF45167.1 - 0.32 11.2 1.2 0.63 10.3 1.2 1.4 1 0 0 1 1 1 0 TrbC/VIRB2 family UbiA PF01040.18 CCF45169.1 - 1.5e-59 201.4 16.8 1.5e-59 201.4 16.8 1.9 1 1 1 2 2 2 1 UbiA prenyltransferase family Caskin1-CID PF16600.5 CCF45170.1 - 2.9 8.5 16.2 0.6 10.7 4.8 2.5 2 0 0 2 2 2 0 Caskin1 CASK-interaction domain CLN3 PF02487.17 CCF45172.1 - 1.6e-79 267.8 0.1 1.9e-79 267.6 0.1 1.0 1 0 0 1 1 1 1 CLN3 protein GTP_EFTU_D3 PF03143.17 CCF45173.1 - 1.3e-41 141.4 0.0 2.6e-41 140.4 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU PF00009.27 CCF45173.1 - 1.6e-17 63.7 0.0 2.5e-17 63.1 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 CCF45173.1 - 1.7e-15 57.1 0.8 4.2e-15 55.9 0.8 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.6 CCF45173.1 - 0.1 12.5 1.0 0.16 11.9 0.3 1.7 2 0 0 2 2 2 0 Elongation factor Tu domain 4 NmrA PF05368.13 CCF45174.1 - 2.3e-41 141.9 0.0 3e-41 141.5 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CCF45174.1 - 1e-24 87.4 0.0 1.4e-24 87.0 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CCF45174.1 - 3.1e-07 30.1 0.0 4.8e-06 26.2 0.0 2.2 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CCF45174.1 - 0.0003 20.3 0.0 0.00055 19.4 0.0 1.4 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 CCF45174.1 - 0.00077 18.6 0.2 0.0027 16.7 0.2 1.7 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family ApbA PF02558.16 CCF45174.1 - 0.03 14.0 0.0 0.049 13.3 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA adh_short PF00106.25 CCF45174.1 - 0.035 13.6 0.0 0.059 12.8 0.0 1.4 1 0 0 1 1 1 0 short chain dehydrogenase F420_oxidored PF03807.17 CCF45174.1 - 0.039 14.5 0.0 0.09 13.4 0.0 1.7 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Aldo_ket_red PF00248.21 CCF45174.1 - 0.11 11.7 0.0 0.16 11.2 0.0 1.2 1 0 0 1 1 1 0 Aldo/keto reductase family DUF2145 PF09916.9 CCF45174.1 - 0.15 11.7 0.0 0.41 10.3 0.0 1.8 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2145) RNase_P_Rpp14 PF01900.19 CCF45176.1 - 7.2e-37 125.8 0.0 9.1e-37 125.4 0.0 1.1 1 0 0 1 1 1 1 Rpp14/Pop5 family ATP_bind_1 PF03029.17 CCF45177.1 - 3.3e-79 266.1 0.0 4.4e-79 265.7 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein MeaB PF03308.16 CCF45177.1 - 0.0055 15.7 0.2 0.014 14.4 0.0 1.6 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_31 PF13614.6 CCF45177.1 - 0.0091 15.9 0.0 0.57 10.1 0.0 2.4 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 CCF45177.1 - 0.035 13.4 0.2 0.11 11.7 0.0 1.9 2 0 0 2 2 2 0 Zeta toxin AAA_29 PF13555.6 CCF45177.1 - 0.043 13.6 0.0 0.087 12.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain GTP_EFTU PF00009.27 CCF45177.1 - 0.068 12.7 0.0 0.39 10.2 0.0 2.2 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 CCF45177.1 - 0.14 12.2 0.0 1.5 8.9 0.0 2.4 2 1 0 2 2 2 0 50S ribosome-binding GTPase AAA_33 PF13671.6 CCF45177.1 - 0.19 11.9 0.4 0.51 10.5 0.0 1.9 2 0 0 2 2 2 0 AAA domain Fer4_NifH PF00142.18 CCF45177.1 - 0.23 10.9 0.2 3 7.2 0.2 2.1 1 1 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family cNMP_binding PF00027.29 CCF45178.1 - 1.5e-27 95.4 0.9 1.4e-15 57.1 0.1 5.5 6 0 0 6 6 6 3 Cyclic nucleotide-binding domain Patatin PF01734.22 CCF45178.1 - 3.1e-14 53.7 4.9 1.3e-12 48.3 4.9 2.8 1 1 0 1 1 1 1 Patatin-like phospholipase Trp_oprn_chp PF09534.10 CCF45179.1 - 7.7 6.3 7.6 0.47 10.2 0.9 2.0 2 0 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Pyridoxal_deC PF00282.19 CCF45180.1 - 1.4e-63 214.9 0.0 1.6e-63 214.7 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain CHORD PF04968.12 CCF45181.1 - 8.3e-49 164.2 18.9 3.6e-25 88.4 6.2 2.2 2 0 0 2 2 2 2 CHORD CS PF04969.16 CCF45181.1 - 7.6e-12 46.1 0.0 1.1e-11 45.5 0.0 1.3 1 0 0 1 1 1 1 CS domain TMEM174 PF15029.6 CCF45183.1 - 0.025 14.3 0.6 0.046 13.4 0.6 1.4 1 0 0 1 1 1 0 Transmembrane protein 174 TIC20 PF16166.5 CCF45183.1 - 1.6 8.5 6.8 0.52 10.1 2.8 2.1 2 0 0 2 2 2 0 Chloroplast import apparatus Tic20-like ANAPC4_WD40 PF12894.7 CCF45184.1 - 0.046 14.0 0.0 1.3 9.4 0.0 2.7 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain DUF3425 PF11905.8 CCF45185.1 - 0.0049 16.8 0.0 0.014 15.4 0.0 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF3425) Auxin_repressed PF05564.12 CCF45185.1 - 0.13 12.9 0.0 0.13 12.9 0.0 1.9 2 0 0 2 2 2 0 Dormancy/auxin associated protein CCDC158 PF15921.5 CCF45185.1 - 0.38 8.5 1.9 0.53 8.0 1.9 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 158 DivIC PF04977.15 CCF45185.1 - 1.4 8.7 4.3 3.2 7.6 4.3 1.6 1 0 0 1 1 1 0 Septum formation initiator Chromate_transp PF02417.15 CCF45186.1 - 3.6e-34 118.2 13.5 3.6e-34 118.2 13.5 1.7 2 0 0 2 2 2 1 Chromate transporter MotA_ExbB PF01618.16 CCF45186.1 - 1.7 8.4 5.8 4.3 7.1 0.1 2.6 3 0 0 3 3 3 0 MotA/TolQ/ExbB proton channel family EnY2 PF10163.9 CCF45190.1 - 0.0071 16.7 0.1 0.012 16.0 0.1 1.3 1 0 0 1 1 1 1 Transcription factor e(y)2 MFS_1 PF07690.16 CCF45193.1 - 5.5e-28 97.9 29.5 1.8e-21 76.5 17.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily PUCC PF03209.15 CCF45193.1 - 0.0037 16.3 8.3 0.12 11.4 8.3 2.2 1 1 0 1 1 1 1 PUCC protein OATP PF03137.20 CCF45193.1 - 0.0078 14.5 1.8 0.33 9.2 0.0 2.6 2 1 1 3 3 3 2 Organic Anion Transporter Polypeptide (OATP) family MccV PF17508.2 CCF45193.1 - 0.26 11.8 1.2 0.5 10.9 0.1 2.0 2 0 0 2 2 2 0 Microcin V bacteriocin Ferlin_C PF16165.5 CCF45194.1 - 0.071 13.1 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 Ferlin C-terminus Dioxygenase_C PF00775.21 CCF45195.1 - 1.5e-09 37.5 0.8 5.5e-09 35.7 0.8 1.9 1 1 0 1 1 1 1 Dioxygenase DUF1996 PF09362.10 CCF45197.1 - 1.6e-42 146.1 0.3 2.1e-42 145.8 0.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) Sugar_tr PF00083.24 CCF45198.1 - 7.8e-15 54.7 7.8 9.8e-15 54.3 7.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF45198.1 - 3e-11 42.9 9.3 3.2e-11 42.8 9.3 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily OATP PF03137.20 CCF45198.1 - 0.00022 19.7 0.9 0.00029 19.3 0.5 1.4 1 1 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family SATase_N PF06426.14 CCF45198.1 - 0.21 12.0 0.0 0.28 11.6 0.0 1.1 1 0 0 1 1 1 0 Serine acetyltransferase, N-terminal Ank_2 PF12796.7 CCF45200.1 - 6.9e-40 135.5 0.0 1.9e-07 31.5 0.0 5.2 4 1 0 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CCF45200.1 - 1.3e-31 108.6 0.3 5.9e-05 23.5 0.0 8.7 5 4 6 11 11 11 9 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCF45200.1 - 1.4e-29 98.8 4.5 0.00038 20.7 0.0 11.4 12 1 1 13 13 13 6 Ankyrin repeat Ank_5 PF13857.6 CCF45200.1 - 3.7e-28 97.2 5.1 2.3e-07 30.9 0.0 7.3 6 2 1 7 7 7 6 Ankyrin repeats (many copies) Ank PF00023.30 CCF45200.1 - 9.6e-26 89.1 3.4 0.00063 20.1 0.0 9.8 11 0 0 11 11 11 6 Ankyrin repeat Ribosomal_L7Ae PF01248.26 CCF45200.1 - 0.036 13.8 0.0 1.6 8.5 0.0 2.5 2 0 0 2 2 2 0 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Metallophos_2 PF12850.7 CCF45202.1 - 4.1e-12 46.6 0.0 5.3e-12 46.2 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Shugoshin_C PF07557.11 CCF45203.1 - 1.9e-11 43.5 7.3 1.9e-11 43.5 7.3 2.7 2 0 0 2 2 2 1 Shugoshin C terminus Shugoshin_N PF07558.11 CCF45203.1 - 2.6e-06 27.2 3.1 4.9e-06 26.3 3.1 1.5 1 0 0 1 1 1 1 Shugoshin N-terminal coiled-coil region DASH_Dad2 PF08654.10 CCF45204.1 - 7.1e-32 109.8 0.4 1.1e-31 109.2 0.4 1.3 1 0 0 1 1 1 1 DASH complex subunit Dad2 Seryl_tRNA_N PF02403.22 CCF45204.1 - 0.007 16.6 0.2 0.015 15.5 0.2 1.5 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain Rogdi_lz PF10259.9 CCF45204.1 - 0.045 13.2 0.3 0.049 13.1 0.3 1.1 1 0 0 1 1 1 0 Rogdi leucine zipper containing protein LAG1-DNAbind PF09271.11 CCF45205.1 - 1.6 9.4 8.9 0.2 12.3 0.8 3.3 4 0 0 4 4 4 0 LAG1, DNA binding COesterase PF00135.28 CCF45206.1 - 5.1e-67 226.9 0.0 5.7e-67 226.7 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CCF45206.1 - 8.6e-07 29.0 0.8 3.1e-06 27.2 0.8 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold zf-HYPF PF07503.12 CCF45207.1 - 0.009 15.8 1.4 0.026 14.3 1.4 1.8 1 0 0 1 1 1 1 HypF finger FYDLN_acid PF09538.10 CCF45207.1 - 0.019 15.7 0.2 0.089 13.5 0.2 2.1 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) DUF2225 PF09986.9 CCF45207.1 - 0.19 11.5 0.4 0.28 10.9 0.4 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2225) PMP1_2 PF08114.11 CCF45207.1 - 0.61 9.9 2.4 0.89 9.3 0.1 2.2 2 0 0 2 2 2 0 ATPase proteolipid family LIDHydrolase PF10230.9 CCF45209.1 - 5.2e-57 193.4 0.0 6.1e-57 193.2 0.0 1.1 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Abhydrolase_6 PF12697.7 CCF45209.1 - 0.00041 21.0 1.6 0.00055 20.6 1.6 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CCF45209.1 - 0.018 14.7 0.2 6 6.4 0.2 2.1 2 0 0 2 2 2 0 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CCF45209.1 - 0.066 12.5 0.0 0.14 11.4 0.0 1.5 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Oxidored_molyb PF00174.19 CCF45210.1 - 8.7e-56 188.2 0.0 1.2e-55 187.8 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.16 CCF45210.1 - 5.6e-31 107.4 0.4 9.3e-31 106.7 0.4 1.3 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain BNR PF02012.20 CCF45210.1 - 0.028 14.4 0.3 0.1 12.7 0.3 2.0 1 0 0 1 1 1 0 BNR/Asp-box repeat Cas6 PF09559.10 CCF45210.1 - 0.095 12.7 0.0 1.8 8.5 0.0 2.1 2 0 0 2 2 2 0 Cas6 Crispr ADH_N PF08240.12 CCF45212.1 - 2.5e-08 33.8 0.0 6.3e-07 29.3 0.0 2.2 1 1 1 2 2 2 2 Alcohol dehydrogenase GroES-like domain Epimerase PF01370.21 CCF45213.1 - 4.9e-16 58.9 0.0 1.1e-15 57.7 0.0 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CCF45213.1 - 2.8e-14 52.8 0.0 1.7e-13 50.2 0.0 1.8 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 CCF45213.1 - 1.6e-09 38.0 0.0 2.2e-09 37.5 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 CCF45213.1 - 2.7e-09 36.6 0.0 7.1e-08 31.9 0.0 2.0 1 1 0 1 1 1 1 Male sterility protein GDP_Man_Dehyd PF16363.5 CCF45213.1 - 1.3e-06 28.0 0.1 1.9e-06 27.5 0.1 1.4 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase KR PF08659.10 CCF45213.1 - 2.5e-06 27.5 0.0 4.1e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 KR domain NmrA PF05368.13 CCF45213.1 - 0.00061 19.4 0.2 0.00085 18.9 0.2 1.4 1 1 0 1 1 1 1 NmrA-like family RmlD_sub_bind PF04321.17 CCF45213.1 - 0.0023 17.1 0.0 0.0038 16.4 0.0 1.4 1 0 0 1 1 1 1 RmlD substrate binding domain ApbA PF02558.16 CCF45213.1 - 0.0074 15.9 0.0 0.011 15.4 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Polysacc_synt_2 PF02719.15 CCF45213.1 - 0.013 14.6 0.0 0.018 14.2 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein adh_short PF00106.25 CCF45213.1 - 0.028 13.9 0.2 0.21 11.0 0.1 2.2 2 1 0 2 2 2 0 short chain dehydrogenase F420_oxidored PF03807.17 CCF45213.1 - 0.029 14.9 0.0 0.057 14.0 0.0 1.5 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Sacchrp_dh_NADP PF03435.18 CCF45213.1 - 0.055 13.7 0.0 0.087 13.1 0.0 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain SHR-BD PF06650.12 CCF45214.1 - 7.3e-09 35.4 0.0 2.5e-05 23.8 0.0 3.6 5 1 0 5 5 5 2 SHR-binding domain of vacuolar-sorting associated protein 13 zf-C2H2 PF00096.26 CCF45216.1 - 0.0023 18.3 21.0 0.0033 17.8 0.5 4.3 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCF45216.1 - 0.0059 17.3 0.7 0.0059 17.3 0.7 4.4 4 0 0 4 4 4 1 C2H2-type zinc finger zf-C2H2_2 PF12756.7 CCF45216.1 - 0.012 15.9 1.6 0.036 14.4 1.6 1.8 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) FOXP-CC PF16159.5 CCF45216.1 - 2.8 8.6 8.1 4.2 8.1 0.8 2.8 1 1 1 2 2 2 0 FOXP coiled-coil domain zf-C2H2_6 PF13912.6 CCF45216.1 - 4 7.6 6.6 0.23 11.5 0.8 2.0 2 0 0 2 2 2 0 C2H2-type zinc finger DUF202 PF02656.15 CCF45217.1 - 7.1e-05 23.2 2.8 7.1e-05 23.2 2.8 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF202) WD40 PF00400.32 CCF45219.1 - 3.1e-27 94.3 6.3 4e-09 36.9 0.2 4.6 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF45219.1 - 3.1e-10 40.2 1.3 0.00092 19.5 0.1 3.2 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain NLE PF08154.12 CCF45219.1 - 0.012 16.2 0.0 0.021 15.3 0.0 1.3 1 0 0 1 1 1 0 NLE (NUC135) domain DUF2427 PF10348.9 CCF45220.1 - 0.0094 15.7 2.8 0.019 14.7 0.7 2.4 3 0 0 3 3 3 1 Domain of unknown function (DUF2427) Gelsolin PF00626.22 CCF45221.1 - 7.4e-05 22.6 0.0 0.00018 21.3 0.0 1.7 2 0 0 2 2 2 1 Gelsolin repeat NapD PF03927.13 CCF45221.1 - 0.03 14.4 0.0 8.2 6.6 0.0 2.2 2 0 0 2 2 2 0 NapD protein Cut8 PF08559.10 CCF45222.1 - 3.6e-75 252.7 0.0 4.5e-75 252.4 0.0 1.0 1 0 0 1 1 1 1 Cut8, nuclear proteasome tether protein Rdx PF10262.9 CCF45223.1 - 2.8e-34 117.1 0.0 4.5e-34 116.5 0.0 1.3 1 0 0 1 1 1 1 Rdx family 2_5_RNA_ligase2 PF13563.6 CCF45225.1 - 7.4e-31 107.1 0.0 2e-30 105.7 0.0 1.8 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily PAP_central PF04928.17 CCF45225.1 - 6.8e-19 67.8 0.0 1.5e-18 66.7 0.0 1.5 1 0 0 1 1 1 1 Poly(A) polymerase central domain MJ1316 PF04457.12 CCF45225.1 - 1.9e-17 63.8 0.8 4.4e-17 62.6 0.8 1.7 1 0 0 1 1 1 1 MJ1316 RNA cyclic group end recognition domain Exo_endo_phos PF03372.23 CCF45225.1 - 4e-06 26.5 0.0 1.1e-05 25.1 0.0 1.8 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family NTP_transf_2 PF01909.23 CCF45225.1 - 0.00014 22.1 0.0 0.00035 20.8 0.0 1.7 1 0 0 1 1 1 1 Nucleotidyltransferase domain LigT_PEase PF02834.16 CCF45225.1 - 0.019 15.1 0.0 0.15 12.2 0.0 2.5 3 0 0 3 3 3 0 LigT like Phosphoesterase Exo70 PF03081.15 CCF45226.1 - 1.3e-86 291.1 0.0 1.4e-86 290.9 0.0 1.0 1 0 0 1 1 1 1 Exo70 exocyst complex subunit MFS_1 PF07690.16 CCF45227.1 - 5.1e-29 101.3 40.3 9.3e-18 64.3 23.1 2.7 2 1 1 3 3 3 2 Major Facilitator Superfamily AAA PF00004.29 CCF45228.1 - 2.2e-22 79.9 0.0 2.4e-20 73.3 0.0 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 CCF45228.1 - 2e-06 27.6 0.0 4.6e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 CCF45228.1 - 0.0038 17.8 0.0 0.0067 17.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.13 CCF45228.1 - 0.0063 15.7 0.0 0.0096 15.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RNA_helicase PF00910.22 CCF45228.1 - 0.015 15.7 0.0 0.051 14.0 0.0 1.9 2 0 0 2 2 2 0 RNA helicase AAA_5 PF07728.14 CCF45228.1 - 0.016 15.2 0.0 0.089 12.8 0.0 2.1 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CCF45228.1 - 0.019 15.4 0.0 0.084 13.2 0.0 1.8 1 1 0 2 2 2 0 AAA ATPase domain TIP49 PF06068.13 CCF45228.1 - 0.098 11.8 0.0 0.18 11.0 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain IstB_IS21 PF01695.17 CCF45228.1 - 0.11 12.2 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_17 PF13207.6 CCF45228.1 - 0.13 12.7 0.2 3.6 8.0 0.1 2.3 1 1 1 2 2 2 0 AAA domain NiFe_hyd_3_EhaA PF17367.2 CCF45229.1 - 0.45 10.7 3.9 2.7 8.2 0.6 3.2 2 1 2 4 4 4 0 NiFe-hydrogenase-type-3 Eha complex subunit A DUF1097 PF06496.11 CCF45229.1 - 2.7 8.1 13.9 0.3 11.2 9.2 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1097) Polysacc_deac_1 PF01522.21 CCF45230.1 - 5.3e-26 90.9 0.0 9.5e-26 90.1 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase Chitin_bind_1 PF00187.19 CCF45230.1 - 2.4e-09 37.5 49.0 1.6e-05 25.3 18.2 3.1 3 0 0 3 3 3 2 Chitin recognition protein BNR_4 PF15892.5 CCF45231.1 - 1.7e-46 158.8 0.2 2.2e-46 158.5 0.2 1.0 1 0 0 1 1 1 1 BNR repeat-containing family member CHRD PF07452.12 CCF45231.1 - 0.13 13.3 0.1 1.8 9.5 0.0 2.2 2 0 0 2 2 2 0 CHRD domain DUF4541 PF15074.6 CCF45233.1 - 0.17 12.5 0.0 0.38 11.4 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4541) HHV6-IE PF03753.13 CCF45233.1 - 0.21 9.0 0.0 0.28 8.6 0.0 1.1 1 0 0 1 1 1 0 Human herpesvirus 6 immediate early protein Ank_2 PF12796.7 CCF45234.1 - 2e-24 86.0 0.1 2.1e-10 41.0 0.0 6.4 4 1 2 6 6 6 5 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CCF45234.1 - 8.1e-20 68.8 12.1 0.034 14.7 0.0 11.0 12 0 0 12 12 12 6 Ankyrin repeat Ank_4 PF13637.6 CCF45234.1 - 1.3e-16 60.7 6.4 0.0001 22.8 0.4 7.7 7 2 0 7 7 7 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 CCF45234.1 - 2.8e-16 59.4 9.1 0.00035 20.8 0.1 7.9 7 1 1 8 8 8 6 Ankyrin repeats (many copies) Ank PF00023.30 CCF45234.1 - 3e-09 36.9 15.4 0.00068 20.0 0.1 8.1 10 0 0 10 10 10 2 Ankyrin repeat Aldo_ket_red PF00248.21 CCF45235.1 - 3.1e-66 223.6 0.0 3.8e-66 223.3 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Methyltransf_23 PF13489.6 CCF45236.1 - 7.4e-19 68.2 0.0 1.1e-18 67.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF45236.1 - 3.7e-08 34.0 0.0 9.9e-08 32.6 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF45236.1 - 6.9e-06 26.6 0.0 2.6e-05 24.8 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF45236.1 - 7e-06 26.7 0.0 2.5e-05 25.0 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF45236.1 - 4.5e-05 23.3 0.0 0.00047 20.0 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CCF45236.1 - 0.00018 21.1 0.0 0.14 11.7 0.0 2.8 2 1 1 3 3 3 2 Methyltransferase small domain Methyltransf_4 PF02390.17 CCF45236.1 - 0.00092 18.7 0.0 0.42 10.1 0.0 2.6 3 0 0 3 3 3 2 Putative methyltransferase FtsJ PF01728.19 CCF45236.1 - 0.0075 16.4 0.0 0.012 15.8 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase FGE-sulfatase PF03781.16 CCF45239.1 - 1.3e-17 64.2 0.5 2.8e-10 40.2 0.2 2.5 2 1 0 2 2 2 2 Sulfatase-modifying factor enzyme 1 DinB_2 PF12867.7 CCF45239.1 - 7.6e-06 26.4 0.2 1.9e-05 25.2 0.2 1.7 1 0 0 1 1 1 1 DinB superfamily Trypsin_2 PF13365.6 CCF45241.1 - 2.7e-28 99.8 0.0 6.3e-28 98.6 0.0 1.6 1 1 0 1 1 1 1 Trypsin-like peptidase domain Peptidase_S46 PF10459.9 CCF45241.1 - 0.015 14.0 0.0 0.059 12.0 0.0 1.8 2 0 0 2 2 2 0 Peptidase S46 Trypsin PF00089.26 CCF45241.1 - 0.022 14.6 0.0 2 8.2 0.0 2.3 2 0 0 2 2 2 0 Trypsin Peptidase_C4 PF00863.19 CCF45241.1 - 0.051 12.9 0.0 0.11 11.8 0.0 1.5 2 0 0 2 2 2 0 Peptidase family C4 Peptidase_S32 PF05579.13 CCF45241.1 - 0.092 11.9 0.1 0.18 11.0 0.1 1.4 1 0 0 1 1 1 0 Equine arteritis virus serine endopeptidase S32 MIT PF04212.18 CCF45242.1 - 3.3e-17 62.3 2.4 4.7e-17 61.8 2.4 1.2 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain DUF1772 PF08592.11 CCF45243.1 - 0.74 10.1 12.5 0.3 11.4 3.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1772) SnoaL_2 PF12680.7 CCF45244.1 - 0.00032 21.3 0.7 0.00052 20.6 0.7 1.4 1 1 0 1 1 1 1 SnoaL-like domain DHDPS PF00701.22 CCF45245.1 - 4.8e-44 150.2 0.0 5.8e-44 149.9 0.0 1.1 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family ubiquitin PF00240.23 CCF45248.1 - 3.9e-34 116.2 0.6 8e-34 115.2 0.6 1.5 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_S27 PF01599.19 CCF45248.1 - 2.2e-26 91.7 1.8 2.2e-26 91.7 1.8 2.0 2 0 0 2 2 2 1 Ribosomal protein S27a Rad60-SLD PF11976.8 CCF45248.1 - 2.4e-16 59.3 0.7 5e-16 58.3 0.7 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 CCF45248.1 - 2.5e-05 24.6 0.6 0.00013 22.4 0.1 2.2 2 1 0 2 2 2 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 CCF45248.1 - 0.0015 18.6 0.6 0.0034 17.5 0.6 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 CCF45248.1 - 0.0048 17.2 0.9 0.0083 16.5 0.0 1.7 1 1 1 2 2 2 1 Ubiquitin-like domain TBK1_ULD PF18396.1 CCF45248.1 - 0.0055 16.6 0.0 0.0083 16.0 0.0 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain DUF2407 PF10302.9 CCF45248.1 - 0.011 16.2 0.8 0.016 15.7 0.8 1.2 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 CCF45248.1 - 0.02 14.9 1.0 5.9 7.0 0.2 2.4 2 0 0 2 2 2 0 Ubiquitin-like domain MFS_1 PF07690.16 CCF45249.1 - 2e-34 119.1 32.0 2e-34 119.1 32.0 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily DAD PF02109.16 CCF45249.1 - 0.32 11.3 0.0 0.32 11.3 0.0 3.2 4 1 0 4 4 4 0 DAD family HRI1 PF16815.5 CCF45250.1 - 3.9e-70 236.1 8.5 1.1e-68 231.5 8.5 2.0 1 1 0 1 1 1 1 Protein HRI1 4HBT_2 PF13279.6 CCF45251.1 - 2.8e-20 73.0 0.3 4.1e-20 72.5 0.3 1.2 1 0 0 1 1 1 1 Thioesterase-like superfamily 4HBT PF03061.22 CCF45251.1 - 0.0017 18.6 0.0 0.0038 17.5 0.0 1.6 1 0 0 1 1 1 1 Thioesterase superfamily FAS_I_H PF18314.1 CCF45252.1 - 1.3e-78 263.3 0.6 3.7e-78 261.8 0.1 2.1 2 0 0 2 2 2 1 Fatty acid synthase type I helical domain Fas_alpha_ACP PF18325.1 CCF45252.1 - 6.6e-76 254.1 0.0 1.3e-75 253.2 0.0 1.5 1 0 0 1 1 1 1 Fatty acid synthase subunit alpha Acyl carrier domain ketoacyl-synt PF00109.26 CCF45252.1 - 5.5e-21 75.3 0.1 1.3e-20 74.1 0.1 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain ACPS PF01648.20 CCF45252.1 - 3.2e-18 65.9 0.0 8.9e-18 64.5 0.0 1.8 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily Ketoacyl-synt_C PF02801.22 CCF45252.1 - 1.6e-11 44.2 0.2 4.5e-11 42.8 0.0 1.9 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain adh_short PF00106.25 CCF45252.1 - 3.2e-05 23.5 0.0 8.9e-05 22.0 0.0 1.8 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF45252.1 - 0.013 15.4 0.0 0.039 13.8 0.0 1.8 1 0 0 1 1 1 0 KR domain Ribosomal_S4 PF00163.19 CCF45252.1 - 0.098 13.6 0.3 0.38 11.7 0.3 2.1 1 0 0 1 1 1 0 Ribosomal protein S4/S9 N-terminal domain DUF1729 PF08354.10 CCF45254.1 - 1.3e-153 511.1 0.0 1.9e-153 510.6 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) Acyl_transf_1 PF00698.21 CCF45254.1 - 5.1e-89 298.9 0.0 1e-87 294.7 0.0 2.7 3 0 0 3 3 3 1 Acyl transferase domain FAS_meander PF17951.1 CCF45254.1 - 3e-55 186.1 0.0 8.5e-55 184.6 0.0 1.8 1 0 0 1 1 1 1 Fatty acid synthase meander beta sheet domain FAS_N PF17828.1 CCF45254.1 - 3.1e-40 137.2 0.0 6.7e-40 136.1 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain in fatty acid synthase subunit beta MaoC_dehydratas PF01575.19 CCF45254.1 - 3.4e-38 130.0 0.0 7.4e-38 128.9 0.0 1.6 1 0 0 1 1 1 1 MaoC like domain SAT PF16073.5 CCF45254.1 - 5.4e-35 121.3 0.0 1.6e-34 119.7 0.0 1.8 2 0 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis MaoC_dehydrat_N PF13452.6 CCF45254.1 - 2.3e-24 86.0 0.0 8.3e-24 84.2 0.0 2.1 1 0 0 1 1 1 1 N-terminal half of MaoC dehydratase NMO PF03060.15 CCF45254.1 - 0.00042 19.8 0.1 0.0022 17.4 0.1 2.1 1 1 0 1 1 1 1 Nitronate monooxygenase MRP-L47 PF06984.13 CCF45257.1 - 1.4e-23 82.8 0.5 2.4e-23 82.1 0.5 1.4 1 0 0 1 1 1 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) DNA_ligase_A_M PF01068.21 CCF45260.1 - 5e-61 205.9 1.1 9.8e-49 165.8 0.3 2.3 2 0 0 2 2 2 2 ATP dependent DNA ligase domain DNA_ligase_A_C PF04679.15 CCF45260.1 - 6e-29 100.6 0.0 2e-28 98.9 0.0 1.9 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region DNA_ligase_A_N PF04675.14 CCF45260.1 - 1.1e-14 55.2 0.0 2.4e-14 54.0 0.0 1.6 1 0 0 1 1 1 1 DNA ligase N terminus RNA_ligase PF09414.10 CCF45260.1 - 1e-05 25.9 0.1 1.5e-05 25.3 0.1 1.3 1 0 0 1 1 1 1 RNA ligase PNKP_ligase PF16542.5 CCF45260.1 - 0.09 12.2 0.0 0.16 11.4 0.0 1.4 1 0 0 1 1 1 0 PNKP adenylyltransferase domain, ligase domain DUF4854 PF16146.5 CCF45260.1 - 0.13 12.6 0.5 3.4 8.0 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4854) TPP_enzyme_N PF02776.18 CCF45261.1 - 4.3e-33 114.3 0.0 7.1e-33 113.6 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 CCF45261.1 - 1.7e-21 76.4 0.0 3.4e-21 75.4 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 CCF45261.1 - 2.5e-16 59.8 0.2 2e-15 56.9 0.1 2.4 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DXP_synthase_N PF13292.6 CCF45261.1 - 0.0059 15.9 0.0 0.009 15.2 0.0 1.2 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase E1_dh PF00676.20 CCF45261.1 - 0.0099 14.9 0.1 0.017 14.1 0.1 1.3 1 0 0 1 1 1 1 Dehydrogenase E1 component E1-N PF14463.6 CCF45261.1 - 0.14 12.0 0.2 0.5 10.2 0.0 2.0 3 0 0 3 3 3 0 E1 N-terminal domain THUMP PF02926.17 CCF45262.1 - 2.2e-08 34.3 3.5 2.8e-07 30.7 0.1 2.8 2 1 1 3 3 3 2 THUMP domain DUF2415 PF10313.9 CCF45267.1 - 3.9e-13 49.1 0.0 7.8e-13 48.1 0.0 1.5 1 0 0 1 1 1 1 Uncharacterised protein domain (DUF2415) ANAPC4_WD40 PF12894.7 CCF45267.1 - 0.11 12.8 0.0 4 7.8 0.0 3.2 4 0 0 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain HET PF06985.11 CCF45269.1 - 6.4e-10 39.5 12.2 1.3e-09 38.5 1.9 2.8 2 1 1 3 3 3 2 Heterokaryon incompatibility protein (HET) DPM3 PF08285.11 CCF45271.1 - 4.2 7.6 5.2 9.9 6.4 5.2 1.6 1 0 0 1 1 1 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) CAP_C PF08603.11 CCF45272.1 - 2.2e-57 193.1 2.7 2.5e-57 192.9 2.7 1.0 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal CAP_N PF01213.19 CCF45272.1 - 0.054 13.0 0.1 0.054 13.0 0.1 1.6 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal TBCC PF07986.12 CCF45272.1 - 0.067 12.9 2.3 0.42 10.3 1.4 2.0 1 1 1 2 2 2 0 Tubulin binding cofactor C Carn_acyltransf PF00755.20 CCF45273.1 - 9.3e-92 308.5 0.0 1e-91 308.4 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase PolyA_pol PF01743.20 CCF45274.1 - 3.8e-18 66.1 0.1 1e-17 64.7 0.1 1.7 1 0 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 CCF45274.1 - 4.1e-07 29.7 0.0 8.2e-07 28.7 0.0 1.5 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A tRNA_NucTran2_2 PF13735.6 CCF45274.1 - 0.012 15.6 0.0 0.02 14.9 0.0 1.4 1 0 0 1 1 1 0 tRNA nucleotidyltransferase domain 2 putative TolA_bind_tri PF16331.5 CCF45275.1 - 0.26 11.4 7.2 1.1 9.3 0.2 2.9 1 1 1 2 2 2 0 TolA binding protein trimerisation Atg14 PF10186.9 CCF45275.1 - 0.5 9.4 7.7 0.71 8.9 7.7 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Allexi_40kDa PF05549.11 CCF45275.1 - 1.7 8.1 5.1 1.6 8.1 2.8 1.8 1 1 0 2 2 2 0 Allexivirus 40kDa protein GrpE PF01025.19 CCF45276.1 - 3.2e-07 30.2 0.0 3.5e-07 30.0 0.0 1.1 1 0 0 1 1 1 1 GrpE DUF3391 PF11871.8 CCF45277.1 - 0.019 15.5 0.3 0.019 15.5 0.3 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3391) AA_permease PF00324.21 CCF45280.1 - 1.2e-115 386.8 44.8 1.5e-115 386.6 44.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CCF45280.1 - 1.2e-34 119.9 45.7 1.4e-34 119.7 45.7 1.1 1 0 0 1 1 1 1 Amino acid permease ADH_zinc_N PF00107.26 CCF45281.1 - 2e-08 34.3 1.0 3.8e-08 33.4 1.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCF45281.1 - 0.00094 19.0 0.0 0.0018 18.2 0.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain BSP_II PF05432.11 CCF45283.1 - 0.1 12.3 33.4 0.3 10.8 16.3 2.9 3 0 0 3 3 3 0 Bone sialoprotein II (BSP-II) TFIIF_alpha PF05793.12 CCF45283.1 - 3.6 6.1 43.5 0.55 8.8 1.3 3.1 3 0 0 3 3 3 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) PTPRCAP PF15713.5 CCF45283.1 - 4.6 7.5 39.1 1.5 9.1 4.4 3.3 3 0 0 3 3 3 0 Protein tyrosine phosphatase receptor type C-associated Plasmodium_Vir PF05795.11 CCF45283.1 - 7.2 5.9 7.7 14 5.0 7.7 1.4 1 0 0 1 1 1 0 Plasmodium vivax Vir protein YibE_F PF07907.11 CCF45284.1 - 0.0067 15.9 0.1 0.012 15.2 0.1 1.3 1 0 0 1 1 1 1 YibE/F-like protein peroxidase PF00141.23 CCF45286.1 - 4.6e-25 88.6 0.0 6.7e-25 88.1 0.0 1.2 1 0 0 1 1 1 1 Peroxidase DNA_processg_A PF02481.15 CCF45287.1 - 0.048 12.9 0.0 0.066 12.5 0.0 1.2 1 0 0 1 1 1 0 DNA recombination-mediator protein A XAP5 PF04921.14 CCF45288.1 - 2.7e-92 309.1 0.0 3.8e-92 308.6 0.0 1.2 1 0 0 1 1 1 1 XAP5, circadian clock regulator DUF4604 PF15377.6 CCF45288.1 - 8.3e-05 23.1 2.9 0.00017 22.0 2.9 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) bZIP_1 PF00170.21 CCF45289.1 - 0.00064 19.8 17.2 0.025 14.7 17.2 2.6 1 1 0 1 1 1 1 bZIP transcription factor Jnk-SapK_ap_N PF09744.9 CCF45289.1 - 0.0027 17.9 5.5 0.0045 17.2 5.5 1.3 1 0 0 1 1 1 1 JNK_SAPK-associated protein-1 Mto2_bdg PF12808.7 CCF45289.1 - 0.029 14.6 5.9 0.029 14.6 5.9 2.9 2 1 1 3 3 3 0 Micro-tubular organiser Mto1 C-term Mto2-binding region DUF4763 PF15960.5 CCF45289.1 - 0.042 13.1 6.2 0.078 12.3 6.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) SIKE PF05769.11 CCF45289.1 - 0.063 13.2 5.9 0.15 12.0 5.9 1.6 1 1 0 1 1 1 0 SIKE family HAUS-augmin3 PF14932.6 CCF45289.1 - 0.066 12.8 7.1 0.11 12.0 7.1 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 DUF4515 PF14988.6 CCF45289.1 - 0.083 12.7 8.0 0.14 12.0 8.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4515) HALZ PF02183.18 CCF45289.1 - 0.099 12.9 0.4 0.099 12.9 0.4 1.9 2 0 0 2 2 1 0 Homeobox associated leucine zipper GIT_CC PF16559.5 CCF45289.1 - 0.12 12.2 3.9 1.1 9.1 2.4 2.5 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor LOH1CR12 PF10158.9 CCF45289.1 - 0.17 11.9 2.5 0.32 11.0 2.5 1.4 1 0 0 1 1 1 0 Tumour suppressor protein NARP1 PF12569.8 CCF45289.1 - 0.3 9.9 5.2 0.42 9.5 5.2 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF5320 PF17253.2 CCF45289.1 - 0.32 12.1 1.6 0.75 10.9 1.6 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5320) ATG16 PF08614.11 CCF45289.1 - 0.42 10.8 15.9 0.1 12.8 12.7 1.6 2 0 0 2 2 1 0 Autophagy protein 16 (ATG16) DUF5094 PF17015.5 CCF45289.1 - 0.55 10.3 2.6 0.82 9.7 2.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5094) Med21 PF11221.8 CCF45289.1 - 0.64 10.3 10.8 21 5.3 10.8 2.5 1 1 0 1 1 1 0 Subunit 21 of Mediator complex DUF4407 PF14362.6 CCF45289.1 - 0.8 9.0 4.8 1.2 8.4 4.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Fib_alpha PF08702.10 CCF45289.1 - 1.4 9.1 6.4 3.5 7.8 5.3 1.9 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF4611 PF15387.6 CCF45289.1 - 2.7 8.3 9.6 1.3 9.3 4.8 2.7 1 1 0 2 2 2 0 Domain of unknown function (DUF4611) Atg14 PF10186.9 CCF45289.1 - 2.9 6.9 9.3 4.3 6.3 9.3 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 SLX9 PF15341.6 CCF45289.1 - 6.3 7.2 13.5 4.6 7.6 4.3 2.4 1 1 1 2 2 2 0 Ribosome biogenesis protein SLX9 Cu-oxidase_3 PF07732.15 CCF45290.1 - 4.2e-39 133.2 1.1 6.9e-39 132.5 1.1 1.4 1 0 0 1 1 1 1 Multicopper oxidase AA_permease PF00324.21 CCF45293.1 - 6.9e-148 493.2 34.6 7.9e-148 493.0 34.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CCF45293.1 - 2.8e-41 141.8 39.3 3.6e-41 141.4 39.3 1.1 1 0 0 1 1 1 1 Amino acid permease EAP30 PF04157.16 CCF45294.1 - 0.17 11.2 0.0 0.26 10.5 0.0 1.2 1 0 0 1 1 1 0 EAP30/Vps36 family Abhydrolase_3 PF07859.13 CCF45296.1 - 8e-20 71.6 0.1 1.1e-19 71.2 0.1 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 CCF45296.1 - 0.00021 20.3 0.0 0.00054 19.0 0.0 1.6 2 0 0 2 2 2 1 Carboxylesterase family Abhydrolase_2 PF02230.16 CCF45296.1 - 0.1 12.4 0.0 0.16 11.7 0.0 1.2 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase IATP PF04568.12 CCF45297.1 - 0.1 13.0 0.4 0.1 13.0 0.4 2.0 2 0 0 2 2 2 0 Mitochondrial ATPase inhibitor, IATP Ligase_CoA PF00549.19 CCF45298.1 - 1.8e-11 44.1 0.2 2.5e-11 43.6 0.2 1.2 1 0 0 1 1 1 1 CoA-ligase Glyco_hydro_3_C PF01915.22 CCF45298.1 - 0.015 15.2 0.0 0.015 15.2 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 3 C-terminal domain DUF5427 PF10310.9 CCF45299.1 - 6.5e-179 595.7 0.1 7.8e-179 595.5 0.1 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5427) Flu_M1_C PF08289.11 CCF45299.1 - 0.037 14.2 0.3 0.1 12.8 0.3 1.7 1 0 0 1 1 1 0 Influenza Matrix protein (M1) C-terminal domain DUF1631 PF07793.11 CCF45299.1 - 0.5 8.7 9.5 0.76 8.1 9.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1631) Ndc1_Nup PF09531.10 CCF45299.1 - 4.3 5.9 5.6 6 5.4 5.6 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup EthD PF07110.11 CCF45300.1 - 1.1e-10 42.5 0.0 1.5e-10 42.1 0.0 1.1 1 0 0 1 1 1 1 EthD domain DUF1689 PF07954.11 CCF45301.1 - 0.075 13.4 0.0 0.099 13.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1689) Tim17 PF02466.19 CCF45301.1 - 0.1 13.0 1.3 2.7 8.4 1.3 2.1 1 1 0 1 1 1 0 Tim17/Tim22/Tim23/Pmp24 family Pico_P1A PF02226.16 CCF45301.1 - 0.2 11.7 0.1 0.97 9.5 0.1 2.1 1 1 0 1 1 1 0 Picornavirus coat protein (VP4) Elong_Iki1 PF10483.9 CCF45302.1 - 0.19 11.2 0.0 0.21 11.0 0.0 1.1 1 0 0 1 1 1 0 Elongator subunit Iki1 DDE_1 PF03184.19 CCF45303.1 - 3e-40 137.7 0.0 2e-25 89.4 0.0 2.2 1 1 1 2 2 2 2 DDE superfamily endonuclease DDE_3 PF13358.6 CCF45303.1 - 0.0006 19.6 0.0 0.0025 17.6 0.0 2.0 3 0 0 3 3 3 1 DDE superfamily endonuclease RRN3 PF05327.11 CCF45304.1 - 4.5e-174 580.1 0.0 4.5e-174 580.1 0.0 1.7 2 0 0 2 2 2 1 RNA polymerase I specific transcription initiation factor RRN3 IBN_N PF03810.19 CCF45304.1 - 0.04 13.8 0.0 0.16 11.9 0.0 2.0 2 0 0 2 2 2 0 Importin-beta N-terminal domain PAC3 PF10178.9 CCF45304.1 - 0.072 13.2 0.0 0.28 11.4 0.0 2.0 1 0 0 1 1 1 0 Proteasome assembly chaperone 3 CBFD_NFYB_HMF PF00808.23 CCF45305.1 - 1.7e-29 101.8 1.0 2.4e-29 101.4 1.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 CCF45305.1 - 1.9e-06 28.2 0.0 3.1e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID-18kDa PF02269.16 CCF45305.1 - 0.0014 18.6 0.0 0.0021 18.1 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit Bromo_TP PF07524.13 CCF45305.1 - 0.002 18.1 0.1 0.0033 17.4 0.1 1.3 1 0 0 1 1 1 1 Bromodomain associated CENP-T_C PF15511.6 CCF45305.1 - 0.0028 17.7 0.0 0.0038 17.3 0.0 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TFIID_20kDa PF03847.13 CCF45305.1 - 0.064 13.8 0.0 0.11 13.0 0.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A Prefoldin_2 PF01920.20 CCF45306.1 - 1.7e-15 56.8 0.8 2.2e-15 56.5 0.8 1.0 1 0 0 1 1 1 1 Prefoldin subunit BRE PF06113.12 CCF45306.1 - 0.051 12.4 0.0 0.054 12.3 0.0 1.1 1 0 0 1 1 1 0 Brain and reproductive organ-expressed protein (BRE) DUF4035 PF13227.6 CCF45306.1 - 0.067 12.9 0.3 0.45 10.3 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4035) p450 PF00067.22 CCF45307.1 - 1.7e-72 244.7 0.0 1.9e-72 244.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Condensation PF00668.20 CCF45308.1 - 2.2e-24 86.0 0.0 1.6e-17 63.4 0.0 3.0 2 1 0 2 2 2 2 Condensation domain PP-binding PF00550.25 CCF45308.1 - 3.4e-09 36.9 0.1 1e-08 35.4 0.1 1.9 1 0 0 1 1 1 1 Phosphopantetheine attachment site FAD_binding_3 PF01494.19 CCF45309.1 - 4.2e-86 289.4 0.0 5.1e-86 289.1 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CCF45309.1 - 2.3e-05 23.8 0.1 6.4e-05 22.3 0.1 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CCF45309.1 - 4.8e-05 22.6 0.1 7.7e-05 21.9 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 CCF45309.1 - 0.0001 21.1 0.0 0.00016 20.5 0.0 1.2 1 0 0 1 1 1 1 HI0933-like protein DAO PF01266.24 CCF45309.1 - 0.00013 21.6 0.1 0.00095 18.8 0.0 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 CCF45309.1 - 0.00016 21.0 0.0 0.0016 17.7 0.0 2.2 2 0 0 2 2 2 1 Thi4 family NAD_binding_8 PF13450.6 CCF45309.1 - 0.001 19.2 0.0 0.0023 18.1 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 CCF45309.1 - 0.0013 17.8 0.0 0.0019 17.3 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein GIDA PF01134.22 CCF45309.1 - 0.0018 17.4 0.0 0.0029 16.8 0.0 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A FAD_oxidored PF12831.7 CCF45309.1 - 0.0032 16.9 0.0 0.0058 16.0 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 CCF45309.1 - 0.0039 16.5 0.0 0.0057 15.9 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCF45309.1 - 0.005 17.4 0.0 0.011 16.3 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 CCF45309.1 - 0.017 14.4 0.0 0.024 13.9 0.0 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain FixH PF05751.11 CCF45309.1 - 0.043 13.8 0.0 0.13 12.3 0.0 1.7 2 0 0 2 2 2 0 FixH SE PF08491.10 CCF45309.1 - 0.093 11.8 0.0 2.1 7.3 0.0 2.2 2 0 0 2 2 2 0 Squalene epoxidase Trp_halogenase PF04820.14 CCF45309.1 - 0.11 11.4 0.0 0.17 10.7 0.0 1.3 1 0 0 1 1 1 0 Tryptophan halogenase XdhC_C PF13478.6 CCF45309.1 - 0.13 12.7 0.0 0.23 12.0 0.0 1.5 1 0 0 1 1 1 0 XdhC Rossmann domain UDPG_MGDP_dh_N PF03721.14 CCF45309.1 - 0.15 11.6 0.0 0.24 11.0 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ChAPs PF09295.10 CCF45310.1 - 4.4e-130 434.2 0.0 5.6e-130 433.9 0.0 1.1 1 0 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_14 PF13428.6 CCF45310.1 - 9.3e-07 29.2 1.4 0.31 12.0 0.6 5.0 4 1 2 6 6 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 CCF45310.1 - 7.2e-05 23.2 0.5 1.5 9.4 0.0 3.8 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 CCF45310.1 - 8.4e-05 22.4 1.0 0.65 10.3 1.8 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_9 PF13371.6 CCF45310.1 - 0.00019 21.5 0.6 0.014 15.6 0.1 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 CCF45310.1 - 0.00021 21.1 0.8 1.2 9.3 0.0 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 CCF45310.1 - 0.00037 20.5 0.4 0.17 12.2 0.1 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 CCF45310.1 - 0.0097 16.5 0.8 27 5.7 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 CCF45310.1 - 0.023 15.0 1.3 7.6 6.9 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 CCF45310.1 - 0.038 14.2 1.6 17 5.7 0.0 3.9 3 1 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 CCF45310.1 - 0.089 12.7 1.0 7.2 6.6 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat CENP-B_dimeris PF09026.10 CCF45310.1 - 0.72 10.3 5.0 1.8 9.0 5.0 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF5324 PF17258.2 CCF45311.1 - 0.0015 18.2 10.2 0.0022 17.7 7.6 2.1 1 1 1 2 2 2 2 Family of unknown function (DUF5324) WSC PF01822.19 CCF45313.1 - 2.8e-47 158.8 46.8 3.7e-17 62.3 9.5 4.6 4 0 0 4 4 4 4 WSC domain PQQ_3 PF13570.6 CCF45313.1 - 6.5e-06 26.5 0.3 0.11 13.0 0.1 3.9 2 0 0 2 2 2 2 PQQ-like domain PQQ PF01011.21 CCF45313.1 - 0.5 10.4 7.6 2.4 8.2 0.2 4.5 4 0 0 4 4 4 0 PQQ enzyme repeat ASH PF15780.5 CCF45313.1 - 8.9 6.6 17.2 1.4 9.2 1.3 4.4 4 1 0 4 4 4 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Beta-lactamase PF00144.24 CCF45314.1 - 8.4e-43 146.9 0.2 1.2e-42 146.3 0.2 1.1 1 0 0 1 1 1 1 Beta-lactamase F-box-like PF12937.7 CCF45315.1 - 0.0061 16.4 0.4 0.013 15.4 0.4 1.6 1 0 0 1 1 1 1 F-box-like ABM PF03992.16 CCF45316.1 - 1.3e-06 28.4 2.6 0.0062 16.6 0.0 3.1 2 1 0 2 2 2 2 Antibiotic biosynthesis monooxygenase HEAT_2 PF13646.6 CCF45317.1 - 5e-09 36.4 0.1 0.0042 17.4 0.0 4.2 3 1 0 4 4 4 2 HEAT repeats HEAT PF02985.22 CCF45317.1 - 5.8e-07 29.2 4.8 0.23 11.8 0.0 5.5 5 0 0 5 5 5 3 HEAT repeat Cnd1 PF12717.7 CCF45317.1 - 9.2e-06 25.8 0.0 0.25 11.4 0.0 2.7 1 1 2 3 3 3 2 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 CCF45317.1 - 9.9e-06 26.1 0.0 0.0074 16.9 0.0 3.4 3 1 0 3 3 3 1 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 CCF45317.1 - 0.00012 22.5 2.4 2.8 8.5 0.0 4.8 4 1 1 5 5 5 2 HEAT-like repeat UNC45-central PF11701.8 CCF45317.1 - 0.0045 17.0 0.0 0.034 14.1 0.0 2.3 2 1 0 2 2 2 1 Myosin-binding striated muscle assembly central CLASP_N PF12348.8 CCF45317.1 - 0.1 12.1 0.0 0.43 10.1 0.0 2.0 1 1 0 1 1 1 0 CLASP N terminal GATA PF00320.27 CCF45317.1 - 0.16 11.6 0.2 0.34 10.6 0.2 1.5 1 0 0 1 1 1 0 GATA zinc finger MutS_I PF01624.20 CCF45319.1 - 2.7e-29 101.7 0.0 3.9e-29 101.2 0.0 1.3 1 0 0 1 1 1 1 MutS domain I PBP1_TM PF14812.6 CCF45319.1 - 1 9.8 9.6 0.18 12.2 4.2 2.3 1 1 1 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal ORC6 PF05460.13 CCF45319.1 - 5.2 6.2 6.1 2.1 7.5 2.9 1.6 1 1 1 2 2 2 0 Origin recognition complex subunit 6 (ORC6) Methyltransf_23 PF13489.6 CCF45320.1 - 1.4e-05 25.0 0.0 2.1e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF45320.1 - 0.00015 22.4 0.0 0.00036 21.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF45320.1 - 0.017 15.8 0.0 0.039 14.6 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 CCF45320.1 - 0.029 14.2 0.0 0.058 13.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 CCF45320.1 - 0.04 13.7 0.0 0.07 12.9 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) FtsJ PF01728.19 CCF45320.1 - 0.14 12.2 0.0 0.18 11.9 0.0 1.3 1 1 0 1 1 1 0 FtsJ-like methyltransferase MFS_1 PF07690.16 CCF45321.1 - 6.1e-15 55.0 0.8 7e-15 54.8 0.8 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF45321.1 - 0.0011 18.0 0.1 0.0011 17.9 0.1 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter CdiI_2 PF18593.1 CCF45321.1 - 0.14 12.9 0.0 0.19 12.4 0.0 1.2 1 0 0 1 1 1 0 CdiI immunity protein Proteasome PF00227.26 CCF45323.1 - 1.1e-33 116.3 0.0 1.3e-33 116.1 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit WD40 PF00400.32 CCF45324.1 - 7.7e-25 86.7 1.5 7.1e-06 26.7 0.1 5.7 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF45324.1 - 0.00022 21.5 0.0 0.089 13.1 0.0 3.2 3 1 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 CCF45324.1 - 0.006 15.9 0.0 0.053 12.9 0.0 2.3 3 1 0 4 4 4 1 WD40-like domain Nup160 PF11715.8 CCF45324.1 - 0.13 10.9 0.0 4.1 5.9 0.0 2.3 2 0 0 2 2 2 0 Nucleoporin Nup120/160 RAB3GAP2_N PF14655.6 CCF45324.1 - 0.16 11.2 0.0 0.28 10.4 0.0 1.4 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Nha1_C PF08619.10 CCF45324.1 - 0.19 10.9 11.9 0.33 10.1 11.9 1.3 1 0 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus Peptidase_C48 PF02902.19 CCF45325.1 - 6.3e-30 104.6 0.0 1.4e-29 103.5 0.0 1.6 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain DUF918 PF06033.11 CCF45326.1 - 0.01 15.9 0.0 0.012 15.7 0.0 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF918) Pectate_lyase PF03211.13 CCF45327.1 - 3.7e-38 131.1 0.2 4.2e-38 130.9 0.2 1.0 1 0 0 1 1 1 1 Pectate lyase ketoacyl-synt PF00109.26 CCF45328.1 - 6e-75 252.1 0.1 8e-75 251.7 0.1 1.2 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 CCF45328.1 - 6.1e-36 123.0 0.2 1.4e-35 121.9 0.1 1.6 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 CCF45328.1 - 5.5e-13 49.4 0.0 1.2e-12 48.3 0.0 1.5 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Thiolase_N PF00108.23 CCF45328.1 - 3e-05 23.5 0.2 5.4e-05 22.7 0.2 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain ACP_syn_III PF08545.10 CCF45328.1 - 0.019 14.8 0.4 0.044 13.6 0.4 1.6 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III DEAD PF00270.29 CCF45330.1 - 8.5e-20 71.2 0.0 1.6e-19 70.3 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF45330.1 - 1.8e-18 66.9 0.0 3.1e-16 59.7 0.0 2.6 2 0 0 2 2 2 2 Helicase conserved C-terminal domain ResIII PF04851.15 CCF45330.1 - 0.017 15.1 0.0 0.032 14.3 0.0 1.4 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit DUF998 PF06197.13 CCF45331.1 - 0.07 12.7 13.5 0.31 10.6 13.4 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF998) FAM60A PF15396.6 CCF45331.1 - 0.084 12.9 0.1 0.14 12.1 0.1 1.3 1 0 0 1 1 1 0 Protein Family FAM60A DUF1011 PF06237.12 CCF45331.1 - 1.7 9.0 7.6 20 5.6 4.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1011) DUF3671 PF12420.8 CCF45331.1 - 4.6 7.3 7.7 15 5.7 0.2 2.6 3 0 0 3 3 3 0 Protein of unknown function HTH_Tnp_Tc5 PF03221.16 CCF45332.1 - 2.2e-12 46.8 0.2 8.1e-12 45.0 0.0 2.0 3 0 0 3 3 3 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 CCF45332.1 - 3.4e-09 36.3 0.1 5.8e-09 35.6 0.1 1.4 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_23 PF13384.6 CCF45332.1 - 0.0031 17.3 0.4 0.012 15.4 0.1 2.1 2 0 0 2 2 2 1 Homeodomain-like domain CENP-B_N PF04218.13 CCF45332.1 - 0.018 14.7 0.0 0.032 13.9 0.0 1.4 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HTH_28 PF13518.6 CCF45332.1 - 0.079 13.1 0.7 0.24 11.6 0.0 2.2 3 0 0 3 3 3 0 Helix-turn-helix domain HTH_8 PF02954.19 CCF45332.1 - 0.16 11.7 0.1 0.69 9.7 0.0 2.0 1 1 1 2 2 2 0 Bacterial regulatory protein, Fis family DUF1932 PF09130.11 CCF45334.1 - 3.4e-22 78.2 0.3 7.9e-22 77.0 0.3 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1932) Maf_N PF08383.11 CCF45337.1 - 0.0012 18.5 0.6 0.0041 16.8 0.2 1.9 2 0 0 2 2 2 1 Maf N-terminal region DUF2721 PF11026.8 CCF45338.1 - 0.0018 18.2 0.1 0.002 18.0 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2721) KAP PF05804.12 CCF45339.1 - 8.5e-05 20.9 0.0 0.018 13.2 0.0 2.1 2 0 0 2 2 2 2 Kinesin-associated protein (KAP) HEAT_2 PF13646.6 CCF45339.1 - 0.00028 21.2 4.8 0.0092 16.3 0.9 4.0 2 1 1 3 3 3 1 HEAT repeats Arm PF00514.23 CCF45339.1 - 0.0041 17.1 6.1 5.4 7.2 0.2 5.4 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 CCF45339.1 - 0.034 14.2 0.0 0.51 10.4 0.0 2.9 2 1 0 2 2 2 0 Spinocerebellar ataxia type 10 protein domain HEAT PF02985.22 CCF45339.1 - 0.034 14.4 4.2 0.051 13.8 0.2 3.4 3 0 0 3 3 3 0 HEAT repeat Borrelia_P83 PF05262.11 CCF45340.1 - 0.012 14.1 18.9 0.016 13.7 18.9 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein Hamartin PF04388.12 CCF45340.1 - 5.9 5.4 12.4 8.1 5.0 12.4 1.1 1 0 0 1 1 1 0 Hamartin protein ORC6 PF05460.13 CCF45340.1 - 7.7 5.7 19.9 13 4.9 19.9 1.3 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) AAA_lid_3 PF17862.1 CCF45341.1 - 8.8e-12 44.6 0.4 1.3e-11 44.1 0.4 1.3 1 0 0 1 1 1 1 AAA+ lid domain AAA PF00004.29 CCF45341.1 - 6.2e-09 36.4 0.1 1.2e-08 35.4 0.0 1.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Ysc84 PF04366.12 CCF45342.1 - 3.6e-16 59.1 0.0 4.9e-16 58.7 0.0 1.2 1 0 0 1 1 1 1 Las17-binding protein actin regulator Aminotran_3 PF00202.21 CCF45343.1 - 8.9e-44 149.7 0.0 7e-24 84.2 0.0 3.1 2 1 0 2 2 2 2 Aminotransferase class-III AAA_26 PF13500.6 CCF45343.1 - 0.00018 21.4 0.0 0.0003 20.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain Mito_carr PF00153.27 CCF45344.1 - 2.1e-37 126.9 0.4 5e-15 55.2 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF4451 PF14616.6 CCF45346.1 - 1.2e-23 83.6 0.1 1.2e-23 83.6 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4451) DUF3488 PF11992.8 CCF45346.1 - 0.61 9.0 3.9 0.97 8.3 3.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3488) FAM60A PF15396.6 CCF45346.1 - 6.9 6.6 6.3 13 5.7 6.3 1.4 1 0 0 1 1 1 0 Protein Family FAM60A WSC PF01822.19 CCF45347.1 - 5.4e-41 138.7 48.8 3.1e-18 65.7 10.6 4.1 4 0 0 4 4 4 3 WSC domain Methyltransf_2 PF00891.18 CCF45348.1 - 1.9e-13 50.2 0.0 2.5e-13 49.8 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase domain Abhydrolase_4 PF08386.10 CCF45349.1 - 1.7e-06 28.0 0.2 2.8e-06 27.4 0.2 1.3 1 0 0 1 1 1 1 TAP-like protein BAH PF01426.18 CCF45351.1 - 0.001 18.9 0.1 0.0038 17.1 0.0 2.0 2 1 0 2 2 2 1 BAH domain zf-RING-like PF08746.11 CCF45351.1 - 0.044 14.1 1.7 0.15 12.4 1.7 1.9 1 0 0 1 1 1 0 RING-like domain Lipoprotein_20 PF13942.6 CCF45351.1 - 0.068 13.1 0.2 0.12 12.3 0.2 1.3 1 0 0 1 1 1 0 YfhG lipoprotein PHD PF00628.29 CCF45351.1 - 1.4 8.8 9.0 0.24 11.3 5.0 1.8 2 0 0 2 2 2 0 PHD-finger KI67R PF08065.12 CCF45352.1 - 0.028 15.0 0.2 0.1 13.1 0.2 2.1 1 0 0 1 1 1 0 KI67R (NUC007) repeat Cauli_DNA-bind PF03310.13 CCF45352.1 - 0.084 12.9 0.2 0.29 11.2 0.2 2.0 1 0 0 1 1 1 0 Caulimovirus DNA-binding protein PBP_sp32 PF07222.12 CCF45355.1 - 2.2 7.7 8.1 2.9 7.3 8.1 1.1 1 0 0 1 1 1 0 Proacrosin binding protein sp32 AMP-binding PF00501.28 CCF45356.1 - 4.6e-22 78.2 0.0 7.1e-22 77.6 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.25 CCF45356.1 - 1.2e-05 25.5 0.0 2.4e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 Phosphopantetheine attachment site NAD_binding_4 PF07993.12 CCF45356.1 - 0.002 17.4 0.0 0.0061 15.8 0.0 1.8 2 0 0 2 2 2 1 Male sterility protein Epimerase PF01370.21 CCF45356.1 - 0.033 13.6 0.0 0.12 11.9 0.0 1.8 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 CCF45356.1 - 0.19 10.8 0.0 0.52 9.4 0.0 1.7 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein p450 PF00067.22 CCF45358.1 - 5.2e-36 124.4 0.0 6.6e-36 124.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Adaptin_N PF01602.20 CCF45360.1 - 3.2e-106 356.0 0.0 3.8e-106 355.7 0.0 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 CCF45360.1 - 4.5e-14 52.8 0.2 4.2e-13 49.6 0.0 2.6 3 1 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 CCF45360.1 - 8.8e-13 48.5 4.1 5.3e-05 23.5 0.0 5.5 4 2 3 7 7 7 5 HEAT repeats HEAT PF02985.22 CCF45360.1 - 2.2e-09 36.8 0.4 0.023 14.9 0.0 6.0 6 0 0 6 6 6 3 HEAT repeat HEAT_EZ PF13513.6 CCF45360.1 - 8.8e-05 22.9 3.5 0.02 15.4 0.0 4.8 5 0 0 5 5 5 1 HEAT-like repeat Cohesin_HEAT PF12765.7 CCF45360.1 - 0.00013 22.1 1.1 0.042 14.2 0.0 3.2 3 0 0 3 3 3 1 HEAT repeat associated with sister chromatid cohesion VHS PF00790.19 CCF45360.1 - 0.088 12.7 0.3 29 4.5 0.1 3.5 4 0 0 4 4 4 0 VHS domain Trehalase PF01204.18 CCF45361.1 - 1.8e-197 657.2 0.0 2.2e-197 656.9 0.0 1.1 1 0 0 1 1 1 1 Trehalase Trehalase_Ca-bi PF07492.11 CCF45361.1 - 1.1e-16 60.2 0.1 1.9e-16 59.5 0.1 1.4 1 0 0 1 1 1 1 Neutral trehalase Ca2+ binding domain Mito_carr PF00153.27 CCF45362.1 - 2.5e-28 97.9 3.7 4.1e-13 49.1 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein E1-E2_ATPase PF00122.20 CCF45366.1 - 7.3e-36 123.4 0.4 1.2e-35 122.7 0.4 1.3 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_N PF00690.26 CCF45366.1 - 3.6e-09 36.2 0.1 6.3e-09 35.4 0.1 1.4 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus CASP_C PF08172.12 CCF45367.1 - 6.5 6.0 19.5 0.29 10.5 13.2 1.9 2 0 0 2 2 2 0 CASP C terminal eIF-3_zeta PF05091.12 CCF45367.1 - 6.6 5.6 13.3 10 5.0 13.3 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) RR_TM4-6 PF06459.12 CCF45367.1 - 6.6 6.5 16.2 12 5.6 16.2 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 USP7_ICP0_bdg PF12436.8 CCF45370.1 - 2.1e-50 171.3 0.8 7.7e-50 169.4 0.1 2.1 1 1 1 2 2 2 2 ICP0-binding domain of Ubiquitin-specific protease 7 UCH PF00443.29 CCF45370.1 - 9.4e-26 90.8 1.1 1.5e-25 90.2 1.1 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CCF45370.1 - 1.9e-07 31.0 0.0 5.4e-07 29.5 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Ald_Xan_dh_C2 PF02738.18 CCF45370.1 - 0.067 11.6 0.0 0.1 11.0 0.0 1.2 1 0 0 1 1 1 0 Molybdopterin-binding domain of aldehyde dehydrogenase Ribosomal_L29e PF01779.17 CCF45371.1 - 8e-23 80.5 8.9 1.2e-22 79.9 8.9 1.3 1 0 0 1 1 1 1 Ribosomal L29e protein family p450 PF00067.22 CCF45372.1 - 4.3e-33 114.8 0.0 7.7e-33 113.9 0.0 1.3 2 0 0 2 2 2 1 Cytochrome P450 DUF3602 PF12223.8 CCF45373.1 - 8.4e-21 74.4 4.6 1.5e-17 63.9 0.7 2.3 1 1 1 2 2 2 2 Protein of unknown function (DUF3602) MFS_5 PF05631.14 CCF45374.1 - 3e-20 72.5 0.6 3.1e-20 72.4 0.6 1.0 1 0 0 1 1 1 1 Sugar-tranasporters, 12 TM Bromodomain PF00439.25 CCF45380.1 - 2.1e-20 72.5 0.2 6.2e-20 71.1 0.2 1.9 1 0 0 1 1 1 1 Bromodomain BET PF17035.5 CCF45380.1 - 4.4e-15 55.6 1.1 1.3e-14 54.1 1.1 1.9 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation YabA PF06156.13 CCF45380.1 - 0.082 13.6 0.1 17 6.1 0.3 3.2 2 2 0 2 2 2 0 Initiation control protein YabA DUF4635 PF15466.6 CCF45380.1 - 0.085 12.4 1.3 0.13 11.7 0.5 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4635) Prefoldin PF02996.17 CCF45380.1 - 0.18 11.7 5.1 1.1 9.2 0.1 3.1 3 0 0 3 3 3 0 Prefoldin subunit PS-DH PF14765.6 CCF45382.1 - 3.1e-56 190.8 1.1 4.3e-56 190.3 1.1 1.1 1 0 0 1 1 1 1 Polyketide synthase dehydratase RNase_P_pop3 PF08228.11 CCF45383.1 - 3.3e-08 33.7 0.0 8.6e-06 25.9 0.0 2.2 2 0 0 2 2 2 2 RNase P subunit Pop3 DUF2457 PF10446.9 CCF45384.1 - 0.3 10.2 2.7 0.34 10.0 2.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DUF917 PF06032.12 CCF45385.1 - 8e-78 261.7 0.0 8.9e-78 261.6 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF917) DUF1937 PF09152.10 CCF45386.1 - 0.14 13.0 0.2 0.3 11.9 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1937) Thioredoxin PF00085.20 CCF45387.1 - 1.7e-62 207.8 5.0 2.5e-31 107.7 0.1 4.0 4 0 0 4 4 4 3 Thioredoxin Thioredoxin_6 PF13848.6 CCF45387.1 - 5.8e-49 166.5 1.0 1.2e-36 126.3 0.2 3.6 2 2 1 3 3 3 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 CCF45387.1 - 3.5e-10 40.1 0.1 0.0012 19.1 0.0 4.2 4 1 1 5 5 4 2 Thioredoxin-like Thioredoxin_7 PF13899.6 CCF45387.1 - 2.9e-09 37.0 0.1 0.0013 18.8 0.0 3.1 3 0 0 3 3 3 2 Thioredoxin-like Calsequestrin PF01216.17 CCF45387.1 - 3.3e-09 36.3 0.5 3.3e-09 36.3 0.5 2.2 1 1 2 3 3 3 1 Calsequestrin Thioredoxin_2 PF13098.6 CCF45387.1 - 1.8e-08 34.8 0.6 0.0015 18.9 0.0 3.3 2 1 0 2 2 2 2 Thioredoxin-like domain OST3_OST6 PF04756.13 CCF45387.1 - 9e-08 31.8 0.4 0.015 14.6 0.0 3.2 2 1 1 3 3 3 2 OST3 / OST6 family, transporter family AhpC-TSA PF00578.21 CCF45387.1 - 1.1e-07 31.7 2.0 0.0041 17.0 0.1 3.2 3 1 0 3 3 3 2 AhpC/TSA family Redoxin PF08534.10 CCF45387.1 - 6.9e-06 25.8 6.2 0.0021 17.8 0.0 3.6 4 0 0 4 4 4 2 Redoxin Thioredoxin_4 PF13462.6 CCF45387.1 - 0.029 14.5 4.4 3.6 7.7 0.4 3.8 3 1 0 3 3 3 0 Thioredoxin DSBA PF01323.20 CCF45387.1 - 0.074 12.8 0.0 24 4.6 0.0 3.3 2 1 1 3 3 3 0 DSBA-like thioredoxin domain Polysacc_deac_1 PF01522.21 CCF45388.1 - 7.7e-22 77.5 0.3 1.9e-21 76.3 0.1 1.7 2 0 0 2 2 2 1 Polysaccharide deacetylase Chitin_bind_1 PF00187.19 CCF45388.1 - 7.8e-06 26.3 24.4 7.8e-06 26.3 24.4 3.5 3 1 1 4 4 4 2 Chitin recognition protein MFS_1 PF07690.16 CCF45392.1 - 4.4e-20 71.9 15.8 1.3e-19 70.4 15.8 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily Tmemb_18A PF09771.9 CCF45392.1 - 0.025 15.0 0.0 1.9 8.9 0.0 2.5 2 0 0 2 2 2 0 Transmembrane protein 188 DUF2236 PF09995.9 CCF45393.1 - 0.00082 19.6 0.3 0.0015 18.8 0.3 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2236) RRM_1 PF00076.22 CCF45394.1 - 0.00013 21.8 0.0 0.00025 20.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Importin_rep_5 PF18816.1 CCF45394.1 - 0.0037 17.5 0.2 0.006 16.9 0.2 1.3 1 0 0 1 1 1 1 Importin repeat F-box-like PF12937.7 CCF45396.1 - 0.11 12.4 0.1 0.35 10.8 0.0 1.9 2 0 0 2 2 2 0 F-box-like Rho_N PF07498.12 CCF45397.1 - 0.7 9.9 2.5 0.45 10.5 0.2 1.8 2 0 0 2 2 2 0 Rho termination factor, N-terminal domain p450 PF00067.22 CCF45398.1 - 9.1e-51 173.0 0.0 2.8e-50 171.4 0.0 1.6 1 1 0 1 1 1 1 Cytochrome P450 RVT_connect PF06815.13 CCF45398.1 - 0.49 10.7 3.8 1.4 9.2 3.8 1.7 1 0 0 1 1 1 0 Reverse transcriptase connection domain SQHop_cyclase_N PF13249.6 CCF45399.1 - 1.3e-14 54.0 0.2 1.5e-14 53.8 0.2 1.1 1 0 0 1 1 1 1 Squalene-hopene cyclase N-terminal domain Prenyltrans PF00432.21 CCF45399.1 - 0.00076 19.2 0.1 0.16 11.7 0.1 2.4 2 0 0 2 2 2 2 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_C PF13243.6 CCF45399.1 - 0.013 14.6 0.1 0.017 14.3 0.1 1.1 1 0 0 1 1 1 0 Squalene-hopene cyclase C-terminal domain SKG6 PF08693.10 CCF45402.1 - 0.00087 18.7 0.3 0.002 17.5 0.3 1.6 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Shisa PF13908.6 CCF45402.1 - 0.0017 18.7 0.0 0.0019 18.5 0.0 1.0 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator MLANA PF14991.6 CCF45402.1 - 0.0056 16.9 0.0 0.0079 16.5 0.0 1.2 1 0 0 1 1 1 1 Protein melan-A Rrn6 PF10214.9 CCF45402.1 - 0.017 13.6 0.4 0.016 13.7 0.4 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Amnionless PF14828.6 CCF45402.1 - 0.023 13.6 0.0 0.026 13.4 0.0 1.0 1 0 0 1 1 1 0 Amnionless GAPT PF11770.8 CCF45402.1 - 0.096 12.5 0.0 0.13 12.1 0.0 1.1 1 0 0 1 1 1 0 GRB2-binding adapter (GAPT) Carb_kinase PF01256.17 CCF45403.1 - 3.1e-56 190.6 0.1 4.1e-56 190.2 0.1 1.2 1 0 0 1 1 1 1 Carbohydrate kinase HK PF02110.15 CCF45403.1 - 0.00018 21.0 0.2 0.00033 20.1 0.0 1.5 2 0 0 2 2 2 1 Hydroxyethylthiazole kinase family Phos_pyr_kin PF08543.12 CCF45403.1 - 0.043 13.2 0.1 0.092 12.1 0.1 1.6 1 1 0 1 1 1 0 Phosphomethylpyrimidine kinase MPC PF03650.13 CCF45404.1 - 1.1e-36 125.4 0.0 1.4e-36 125.0 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers Fasciclin PF02469.22 CCF45407.1 - 2.3e-38 131.3 0.0 5.9e-20 71.8 0.0 2.2 2 0 0 2 2 2 2 Fasciclin domain CN_hydrolase PF00795.22 CCF45412.1 - 3.8e-32 111.7 0.0 4.1e-32 111.5 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Sugar_tr PF00083.24 CCF45413.1 - 2.2e-89 300.4 23.4 2.5e-89 300.2 23.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF45413.1 - 1.3e-19 70.4 27.5 1.4e-12 47.2 12.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 CCF45413.1 - 9e-05 21.9 1.2 9e-05 21.9 1.2 2.1 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB MFS_2 PF13347.6 CCF45413.1 - 0.00018 20.2 20.0 0.0067 15.0 7.3 2.7 2 1 1 3 3 3 2 MFS/sugar transport protein MFS_1_like PF12832.7 CCF45413.1 - 0.0066 15.4 5.9 0.0066 15.4 5.9 2.5 2 0 0 2 2 2 1 MFS_1 like family FGGY_C PF02782.16 CCF45414.1 - 7.9e-72 241.1 0.6 1.5e-71 240.2 0.6 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 CCF45414.1 - 3e-63 213.6 0.0 4e-63 213.2 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain DUF1612 PF07756.12 CCF45414.1 - 0.15 12.3 0.0 0.32 11.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1612) NTP_transferase PF00483.23 CCF45415.1 - 1.9e-53 181.6 0.0 4.3e-53 180.4 0.0 1.5 2 0 0 2 2 2 1 Nucleotidyl transferase Hexapep PF00132.24 CCF45415.1 - 2.6e-17 61.8 18.1 3.7e-10 39.1 1.5 3.6 2 2 1 3 3 3 3 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 CCF45415.1 - 1.8e-11 44.7 0.0 2.6e-11 44.2 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep_2 PF14602.6 CCF45415.1 - 6.1e-07 29.1 4.7 1.8e-05 24.4 0.3 3.2 3 1 0 3 3 3 1 Hexapeptide repeat of succinyl-transferase IspD PF01128.19 CCF45415.1 - 0.0074 16.0 0.0 0.012 15.3 0.0 1.3 1 0 0 1 1 1 1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase CTP_transf_3 PF02348.19 CCF45415.1 - 0.014 15.3 0.0 0.027 14.4 0.0 1.4 1 0 0 1 1 1 0 Cytidylyltransferase DUF4954 PF16314.5 CCF45415.1 - 0.18 9.9 0.0 0.41 8.7 0.0 1.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4954) DUF2207 PF09972.9 CCF45416.1 - 8e-07 28.2 0.4 9.1e-07 28.0 0.4 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) Anoctamin PF04547.12 CCF45416.1 - 0.018 13.9 0.1 0.02 13.7 0.1 1.0 1 0 0 1 1 1 0 Calcium-activated chloride channel MPS2 PF17060.5 CCF45416.1 - 0.02 14.1 0.9 0.022 14.1 0.9 1.1 1 0 0 1 1 1 0 Monopolar spindle protein 2 DUF5305 PF17231.2 CCF45416.1 - 0.066 12.6 7.6 0.1 12.0 7.6 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5305) Ac81 PF05820.11 CCF45416.1 - 0.11 12.0 12.3 0.15 11.6 12.3 1.2 1 0 0 1 1 1 0 Baculoviridae AC81 DUF4191 PF13829.6 CCF45416.1 - 0.68 9.2 7.9 0.92 8.8 7.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) Pex24p PF06398.11 CCF45416.1 - 0.7 8.8 8.9 1 8.3 8.9 1.2 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin Marek_A PF02124.15 CCF45416.1 - 2.3 8.0 8.4 2.8 7.7 7.5 1.6 2 0 0 2 2 2 0 Marek's disease glycoprotein A Wzy_C PF04932.15 CCF45416.1 - 3.9 7.1 12.5 6.1 6.5 12.5 1.3 1 0 0 1 1 1 0 O-Antigen ligase Phlebovirus_G2 PF07245.11 CCF45416.1 - 7.4 4.9 6.8 9 4.7 6.8 1.2 1 0 0 1 1 1 0 Phlebovirus glycoprotein G2 DUF2070 PF09843.9 CCF45416.1 - 8.2 4.6 14.6 11 4.2 14.6 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) p450 PF00067.22 CCF45417.1 - 3e-33 115.3 0.0 3.5e-33 115.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DAGAT PF03982.13 CCF45418.1 - 0.00052 19.0 0.3 0.00073 18.5 0.3 1.2 1 0 0 1 1 1 1 Diacylglycerol acyltransferase HR1 PF02185.16 CCF45419.1 - 0.0015 18.6 5.0 0.0015 18.6 5.0 1.6 2 0 0 2 2 2 1 Hr1 repeat PSD5 PF07637.11 CCF45419.1 - 0.0089 16.4 0.9 0.015 15.6 0.9 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1595) IPK PF03770.16 CCF45419.1 - 0.058 13.2 1.1 0.061 13.2 1.1 1.1 1 0 0 1 1 1 0 Inositol polyphosphate kinase Csm1_N PF18504.1 CCF45419.1 - 0.076 13.4 5.5 0.13 12.6 5.5 1.5 1 0 0 1 1 1 0 Csm1 N-terminal domain PA26 PF04636.13 CCF45419.1 - 0.25 10.2 3.2 0.24 10.3 3.2 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) bZIP_1 PF00170.21 CCF45419.1 - 0.32 11.1 12.5 0.68 10.1 12.5 1.5 1 1 0 1 1 1 0 bZIP transcription factor IFT20 PF14931.6 CCF45419.1 - 0.37 11.0 8.9 0.52 10.5 8.9 1.2 1 0 0 1 1 1 0 Intraflagellar transport complex B, subunit 20 DUF4692 PF15763.5 CCF45419.1 - 1.4 9.4 5.3 1.6 9.2 4.7 1.5 1 1 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) Sugar_tr PF00083.24 CCF45420.1 - 5.7e-101 338.6 28.3 6.9e-101 338.3 28.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF45420.1 - 1.5e-20 73.5 33.1 1.5e-20 73.5 33.1 2.7 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF983 PF06170.12 CCF45420.1 - 5 7.6 8.6 0.31 11.5 1.7 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF983) Aldolase_II PF00596.21 CCF45421.1 - 3.5e-49 167.3 0.0 4.2e-49 167.0 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Glyco_hydro_88 PF07470.13 CCF45422.1 - 2.5e-44 151.7 0.2 2.8e-44 151.6 0.2 1.0 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 Peptidase_C32 PF05411.12 CCF45422.1 - 0.18 11.7 0.0 0.26 11.2 0.0 1.2 1 0 0 1 1 1 0 Equine arteritis virus putative proteinase Tannase PF07519.11 CCF45423.1 - 2e-74 251.2 0.6 2.5e-74 250.9 0.6 1.0 1 0 0 1 1 1 1 Tannase and feruloyl esterase Hydrolase_4 PF12146.8 CCF45423.1 - 0.00091 18.6 0.0 0.03 13.6 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Sad1_UNC PF07738.13 CCF45425.1 - 7.5e-09 35.7 0.0 1.1e-07 31.9 0.0 2.2 1 1 0 1 1 1 1 Sad1 / UNC-like C-terminal GerPC PF10737.9 CCF45425.1 - 0.012 15.7 1.0 0.15 12.1 0.1 2.1 1 1 1 2 2 2 0 Spore germination protein GerPC Syntaxin PF00804.25 CCF45425.1 - 0.04 13.6 1.2 0.065 12.9 1.2 1.2 1 0 0 1 1 1 0 Syntaxin Complex1_LYR PF05347.15 CCF45425.1 - 0.23 11.5 1.6 1.4 9.1 1.3 2.4 2 1 0 2 2 2 0 Complex 1 protein (LYR family) PLC-beta_C PF08703.10 CCF45425.1 - 1.4 8.8 6.6 4.8 7.1 6.9 1.6 1 1 0 1 1 1 0 PLC-beta C terminal Dynamin_N PF00350.23 CCF45427.1 - 1.6e-33 116.2 0.0 2.7e-33 115.4 0.0 1.4 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 CCF45427.1 - 1.2e-20 73.9 0.1 2.8e-20 72.7 0.1 1.6 1 1 0 1 1 1 1 Dynamin central region MMR_HSR1 PF01926.23 CCF45427.1 - 0.00024 21.1 0.0 0.00094 19.3 0.0 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_27 PF13514.6 CCF45427.1 - 0.00027 20.6 0.0 0.028 14.0 0.0 2.4 2 0 0 2 2 2 2 AAA domain Synaptobrevin PF00957.21 CCF45432.1 - 0.0013 18.5 0.7 0.012 15.4 0.3 2.0 1 1 1 2 2 2 2 Synaptobrevin Amino_oxidase PF01593.24 CCF45435.1 - 1.1e-17 64.5 0.1 3.5e-14 52.9 0.0 2.3 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CCF45435.1 - 3.8e-09 36.6 0.1 7.9e-09 35.6 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CCF45435.1 - 1.3e-06 27.9 0.0 0.00023 20.5 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CCF45435.1 - 0.00015 21.8 0.1 0.081 12.9 0.0 2.5 2 1 0 2 2 2 2 FAD-NAD(P)-binding HI0933_like PF03486.14 CCF45435.1 - 0.00096 18.0 0.1 0.99 8.0 0.0 2.4 3 0 0 3 3 3 2 HI0933-like protein DAO PF01266.24 CCF45435.1 - 0.0011 18.7 0.3 0.064 12.8 0.1 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 CCF45435.1 - 0.002 17.4 0.1 0.12 11.6 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 CCF45435.1 - 0.018 14.4 0.0 0.026 13.9 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase GIDA PF01134.22 CCF45435.1 - 0.13 11.3 0.4 0.23 10.5 0.1 1.5 2 0 0 2 2 2 0 Glucose inhibited division protein A Aminotran_4 PF01063.19 CCF45436.1 - 2.2e-16 60.4 0.0 2.6e-16 60.1 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV Amidoligase_2 PF12224.8 CCF45437.1 - 0.089 12.4 0.0 0.094 12.4 0.0 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme CBM_1 PF00734.18 CCF45438.1 - 3.5e-09 36.5 12.5 7.8e-09 35.3 12.5 1.6 1 0 0 1 1 1 1 Fungal cellulose binding domain MGC-24 PF05283.11 CCF45438.1 - 0.029 14.8 4.3 0.044 14.2 4.3 1.3 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin CAF1C_H4-bd PF12265.8 CCF45440.1 - 2.3e-14 53.4 0.0 7e-14 51.8 0.0 1.9 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 CCF45440.1 - 1.3e-13 51.2 8.0 5.6e-06 27.0 0.1 4.8 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF45440.1 - 2.1e-08 34.3 0.2 0.025 14.9 0.0 4.3 3 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Borrelia_P83 PF05262.11 CCF45441.1 - 0.21 10.0 10.0 0.22 10.0 10.0 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein DUF4407 PF14362.6 CCF45441.1 - 2.2 7.6 7.3 2.7 7.2 7.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) RR_TM4-6 PF06459.12 CCF45441.1 - 4.2 7.1 9.8 6.7 6.5 9.8 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 CCF45441.1 - 8.3 5.1 6.8 9 4.9 6.8 1.2 1 0 0 1 1 1 0 Presenilin zf-RING_5 PF14634.6 CCF45442.1 - 0.00027 20.8 2.3 0.00062 19.7 2.3 1.6 1 1 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 CCF45442.1 - 0.00032 20.7 1.5 0.00088 19.3 1.5 1.8 1 1 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 CCF45442.1 - 0.00082 19.2 1.4 0.006 16.4 0.4 2.2 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 CCF45442.1 - 0.066 13.1 0.3 0.066 13.1 0.3 1.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CCF45442.1 - 0.073 13.4 2.2 0.17 12.3 0.6 2.1 2 0 0 2 2 2 0 Ring finger domain zf-C3HC4 PF00097.25 CCF45442.1 - 0.079 12.8 0.6 0.18 11.7 0.6 1.5 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CCF45442.1 - 0.083 12.8 2.7 0.15 11.9 0.4 2.1 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Svs_4_5_6 PF17381.2 CCF45442.1 - 2.3 9.3 11.5 2 9.4 2.3 2.6 2 0 0 2 2 2 0 Seminal vesicle secretory proteins 4/5/6 ANAPC4_WD40 PF12894.7 CCF45443.1 - 0.00017 21.8 0.1 0.26 11.6 0.0 2.9 1 1 2 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CCF45443.1 - 0.0032 18.3 0.0 3 8.9 0.0 2.7 3 0 0 3 3 3 2 WD domain, G-beta repeat Lactonase PF10282.9 CCF45443.1 - 0.021 14.1 0.0 0.024 13.9 0.0 1.2 1 0 0 1 1 1 0 Lactonase, 7-bladed beta-propeller HPS3_N PF14761.6 CCF45443.1 - 0.033 13.7 0.0 0.052 13.1 0.0 1.3 1 0 0 1 1 1 0 Hermansky-Pudlak syndrome 3 Sun2_CC2 PF18580.1 CCF45443.1 - 0.19 12.0 0.3 0.66 10.2 0.0 1.9 2 0 0 2 2 2 0 SUN2 coiled coil domain 2 MFS_1 PF07690.16 CCF45444.1 - 1.5e-36 126.1 26.2 1.5e-36 126.1 26.2 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_4 PF06779.14 CCF45444.1 - 5.4e-06 26.0 2.3 5.4e-06 26.0 2.3 2.2 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB MFS_2 PF13347.6 CCF45445.1 - 1.4e-12 46.9 0.3 1.4e-12 46.9 0.3 2.2 2 0 0 2 2 2 2 MFS/sugar transport protein Phage_Gp17 PF17549.2 CCF45446.1 - 0.061 13.3 0.1 0.94 9.5 0.0 2.0 1 1 1 2 2 2 0 Gene Product 17 RESP18 PF14948.6 CCF45447.1 - 0.035 14.4 0.3 7.5 6.9 0.0 2.4 2 0 0 2 2 2 0 RESP18 domain Sec10 PF07393.11 CCF45448.1 - 2.5e-113 380.0 3.1 2.7e-113 379.8 3.1 1.0 1 0 0 1 1 1 1 Exocyst complex component Sec10 Adaptin_N PF01602.20 CCF45450.1 - 6.2e-31 107.5 0.0 7.4e-31 107.3 0.0 1.0 1 0 0 1 1 1 1 Adaptin N terminal region SDA1 PF05285.12 CCF45450.1 - 0.051 13.0 26.0 0.076 12.4 26.0 1.3 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 CCF45450.1 - 0.067 11.4 26.4 0.086 11.0 26.4 1.1 1 0 0 1 1 1 0 Nop14-like family TFIIA PF03153.13 CCF45450.1 - 0.64 9.9 18.9 0.95 9.4 18.9 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit BUD22 PF09073.10 CCF45450.1 - 0.95 8.7 22.1 1.3 8.3 22.1 1.2 1 0 0 1 1 1 0 BUD22 CDC45 PF02724.14 CCF45450.1 - 0.97 7.6 25.7 1.3 7.2 24.1 1.8 2 0 0 2 2 2 0 CDC45-like protein DUF913 PF06025.12 CCF45450.1 - 1.5 7.8 5.5 13 4.6 7.2 1.7 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) CDC27 PF09507.10 CCF45450.1 - 1.6 8.1 15.1 2.1 7.6 15.1 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Presenilin PF01080.17 CCF45450.1 - 5.6 5.6 5.1 7.2 5.3 5.1 1.2 1 0 0 1 1 1 0 Presenilin RNA_pol_Rpc4 PF05132.14 CCF45450.1 - 6.2 7.2 5.9 11 6.4 5.9 1.5 1 0 0 1 1 1 0 RNA polymerase III RPC4 SAPS PF04499.15 CCF45450.1 - 6.6 5.4 9.9 8.2 5.1 9.9 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein ECH_1 PF00378.20 CCF45451.1 - 4e-11 42.7 0.0 4.3e-11 42.6 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CCF45451.1 - 1.1e-05 25.2 0.0 1.3e-05 24.9 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase SHQ1 PF04925.15 CCF45451.1 - 0.25 10.9 0.0 0.32 10.5 0.0 1.1 1 0 0 1 1 1 0 SHQ1 protein Mo-co_dimer PF03404.16 CCF45452.1 - 1.6e-20 73.5 1.3 2.5e-20 72.9 1.3 1.3 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain Hemerythrin PF01814.23 CCF45453.1 - 3.3e-11 43.9 2.3 4.4e-11 43.5 2.3 1.2 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain Peptidase_M28 PF04389.17 CCF45454.1 - 9.6e-35 120.1 0.0 1.2e-34 119.7 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M28 BTB PF00651.31 CCF45455.1 - 2.3e-07 31.0 0.0 1e-06 28.9 0.0 1.9 2 0 0 2 2 2 1 BTB/POZ domain 3HCDH_N PF02737.18 CCF45456.1 - 1.8e-21 76.8 0.0 2.7e-21 76.3 0.0 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 CCF45456.1 - 3.4e-15 56.4 0.0 5e-15 55.9 0.0 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain Glyco_hydro_61 PF03443.14 CCF45462.1 - 1.1e-52 179.0 0.0 1.3e-52 178.7 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 MG2 PF01835.19 CCF45462.1 - 0.031 14.7 0.0 0.055 13.9 0.0 1.4 1 0 0 1 1 1 0 MG2 domain Cnn_1N PF07989.11 CCF45463.1 - 1.7e-09 37.7 7.4 1.7e-09 37.7 7.4 2.3 2 0 0 2 2 2 1 Centrosomin N-terminal motif 1 DUF812 PF05667.11 CCF45463.1 - 0.024 13.5 8.8 0.019 13.9 6.8 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF812) ESP PF16590.5 CCF45463.1 - 0.062 13.6 1.0 0.19 12.0 0.3 2.0 1 1 1 2 2 2 0 Exocrine gland-secreting peptide CENP-H PF05837.12 CCF45463.1 - 0.28 11.6 9.7 2.8 8.4 4.5 2.5 2 0 0 2 2 2 0 Centromere protein H (CENP-H) DUF3450 PF11932.8 CCF45463.1 - 1 8.6 13.7 0.5 9.6 5.8 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3450) APG6_N PF17675.1 CCF45463.1 - 3.5 8.2 11.3 15 6.1 8.6 2.5 2 0 0 2 2 2 0 Apg6 coiled-coil region Gas_vesicle_C PF01304.17 CCF45464.1 - 0.075 13.0 0.1 0.15 12.1 0.1 1.5 1 0 0 1 1 1 0 Gas vesicles protein GVPc repeated domain zf-C6H2 PF15801.5 CCF45466.1 - 0.033 14.5 0.5 0.033 14.5 0.5 2.0 2 0 0 2 2 2 0 zf-MYND-like zinc finger, mRNA-binding HemY_N PF07219.13 CCF45466.1 - 0.95 9.7 5.6 2 8.6 0.8 2.5 2 0 0 2 2 2 0 HemY protein N-terminus NinF PF05810.12 CCF45466.1 - 5.9 6.8 8.9 2 8.3 0.1 3.0 3 0 0 3 3 3 0 NinF protein SF3b10 PF07189.11 CCF45467.1 - 1.9e-31 108.0 0.0 2.1e-31 107.8 0.0 1.0 1 0 0 1 1 1 1 Splicing factor 3B subunit 10 (SF3b10) MAGE PF01454.19 CCF45468.1 - 3.4e-58 196.9 0.0 5.9e-58 196.1 0.0 1.3 1 0 0 1 1 1 1 MAGE family Replic_Relax PF13814.6 CCF45468.1 - 0.062 13.3 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Replication-relaxation SLS PF14611.6 CCF45469.1 - 1.8e-31 109.7 1.2 2.9e-31 109.1 1.2 1.3 1 0 0 1 1 1 1 Mitochondrial inner-membrane-bound regulator Glyco_hydro_11 PF00457.17 CCF45470.1 - 3.6e-46 157.0 1.9 4e-46 156.9 1.9 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 11 SecA_DEAD PF07517.14 CCF45470.1 - 0.027 13.8 0.1 0.031 13.6 0.1 1.1 1 0 0 1 1 1 0 SecA DEAD-like domain NAD_binding_10 PF13460.6 CCF45471.1 - 3.5e-16 59.6 0.0 5.5e-16 59.0 0.0 1.4 1 1 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 CCF45471.1 - 2e-10 40.7 0.0 3e-10 40.1 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family Sacchrp_dh_NADP PF03435.18 CCF45471.1 - 0.00058 20.1 0.0 0.00094 19.4 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.21 CCF45471.1 - 0.0029 17.1 0.0 0.0051 16.3 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Glyco_trans_4_4 PF13579.6 CCF45471.1 - 0.058 13.8 0.4 0.21 12.0 0.2 1.9 2 0 0 2 2 2 0 Glycosyl transferase 4-like domain FYVE PF01363.21 CCF45473.1 - 2.3e-14 53.2 9.9 4.2e-14 52.4 9.9 1.4 1 0 0 1 1 1 1 FYVE zinc finger zf-AN1 PF01428.16 CCF45473.1 - 0.019 15.1 8.0 0.019 15.1 8.0 1.7 2 0 0 2 2 2 0 AN1-like Zinc finger Hamartin PF04388.12 CCF45473.1 - 8.9 4.8 6.9 0.64 8.6 1.3 1.7 2 0 0 2 2 2 0 Hamartin protein STAS PF01740.21 CCF45474.1 - 2.2e-06 27.3 0.0 3.4e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 STAS domain DUF2459 PF09601.10 CCF45474.1 - 0.1 12.4 0.0 0.8 9.5 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2459) SOG2 PF10428.9 CCF45476.1 - 0.89 8.7 6.5 1.1 8.4 6.5 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Ost5 PF05251.12 CCF45478.1 - 0.072 13.4 2.3 0.08 13.2 0.7 1.9 2 0 0 2 2 2 0 Oligosaccharyltransferase subunit 5 SMAP PF15477.6 CCF45479.1 - 4.6e-10 40.3 6.0 4.6e-10 40.3 6.0 5.1 2 1 0 2 2 2 1 Small acidic protein family Formyl_trans_N PF00551.19 CCF45483.1 - 2.3e-19 69.9 0.0 3.1e-19 69.4 0.0 1.2 1 0 0 1 1 1 1 Formyl transferase DUF1366 PF07104.11 CCF45484.1 - 1.2 8.9 8.4 0.088 12.5 0.9 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1366) ABC_membrane_2 PF06472.15 CCF45485.1 - 7.7e-104 346.9 0.5 1.3e-103 346.1 0.5 1.4 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 CCF45485.1 - 2.5e-17 63.7 0.0 6.3e-17 62.4 0.0 1.7 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CCF45485.1 - 0.00012 22.0 0.0 0.00053 19.9 0.0 2.1 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 CCF45485.1 - 0.025 15.1 0.1 0.16 12.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain SMC_N PF02463.19 CCF45485.1 - 0.055 12.9 0.3 0.24 10.8 0.0 2.1 2 1 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CCF45485.1 - 0.084 12.6 0.0 0.19 11.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 CCF45485.1 - 0.14 12.5 0.8 0.45 10.9 0.1 2.1 2 0 0 2 2 2 0 AAA ATPase domain Rad17 PF03215.15 CCF45485.1 - 0.16 11.9 0.0 0.31 10.9 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain zf-CSL PF05207.13 CCF45486.1 - 5.5e-23 80.4 0.8 7.6e-23 80.0 0.8 1.2 1 0 0 1 1 1 1 CSL zinc finger Zn-ribbon_8 PF09723.10 CCF45486.1 - 2.2e-05 24.4 0.6 3.4e-05 23.9 0.6 1.3 1 0 0 1 1 1 1 Zinc ribbon domain Terminase_GpA PF05876.12 CCF45486.1 - 0.02 13.5 0.2 0.023 13.2 0.2 1.1 1 0 0 1 1 1 0 Phage terminase large subunit (GpA) Prok-RING_1 PF14446.6 CCF45486.1 - 0.33 10.9 3.6 0.75 9.8 3.6 1.6 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 tRNA-synt_1 PF00133.22 CCF45487.1 - 6.2e-36 123.8 0.2 6.4e-26 90.8 0.0 3.4 2 2 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 CCF45487.1 - 5.6e-15 55.0 0.1 2.3e-08 33.2 0.0 2.7 3 0 0 3 3 3 2 tRNA synthetases class I (M) Anticodon_1 PF08264.13 CCF45487.1 - 5.8e-12 45.8 0.9 1.5e-11 44.5 0.9 1.7 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 CCF45487.1 - 8.4e-08 31.9 0.0 2.2e-07 30.5 0.0 1.8 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain Clat_adaptor_s PF01217.20 CCF45489.1 - 1.1e-42 145.4 0.0 2.1e-42 144.4 0.0 1.4 1 1 0 1 1 1 1 Clathrin adaptor complex small chain Frataxin_Cyay PF01491.16 CCF45490.1 - 1.6e-37 127.9 0.0 2e-37 127.5 0.0 1.1 1 0 0 1 1 1 1 Frataxin-like domain AJAP1_PANP_C PF15298.6 CCF45491.1 - 0.011 16.0 0.1 0.016 15.5 0.1 1.2 1 0 0 1 1 1 0 AJAP1/PANP C-terminus DUF4381 PF14316.6 CCF45491.1 - 0.031 14.5 0.1 0.042 14.1 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) PhoR PF11808.8 CCF45491.1 - 0.046 14.1 0.1 0.076 13.4 0.1 1.3 1 0 0 1 1 1 0 Phosphate regulon sensor protein PhoR DUF4448 PF14610.6 CCF45491.1 - 0.12 12.2 0.0 0.18 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) DUF3301 PF11743.8 CCF45491.1 - 0.25 11.0 0.4 0.38 10.4 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3301) Response_reg PF00072.24 CCF45492.1 - 1.8e-18 66.7 0.0 2.3e-18 66.4 0.0 1.1 1 0 0 1 1 1 1 Response regulator receiver domain Aldedh PF00171.22 CCF45493.1 - 2.8e-05 22.9 0.1 3.6e-05 22.5 0.1 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Peptidase_S8 PF00082.22 CCF45495.1 - 2.8e-14 53.1 0.2 3.9e-14 52.6 0.2 1.3 1 0 0 1 1 1 1 Subtilase family fn3_5 PF06280.12 CCF45495.1 - 9.8e-08 32.7 0.0 1.6e-07 32.0 0.0 1.3 1 0 0 1 1 1 1 Fn3-like domain DUF1533 PF07550.11 CCF45495.1 - 0.092 12.6 0.1 0.24 11.3 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1533) Glyco_hydro_31 PF01055.26 CCF45496.1 - 7.2e-87 292.4 0.3 9.4e-87 292.0 0.3 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 CCF45496.1 - 5.4e-12 45.9 0.0 2.4e-11 43.8 0.0 2.1 2 0 0 2 2 2 1 Galactose mutarotase-like DUF4968 PF16338.5 CCF45496.1 - 0.13 12.5 0.0 0.29 11.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4968) Cyt-b5 PF00173.28 CCF45497.1 - 0.049 13.8 0.0 2.3 8.5 0.0 2.5 2 0 0 2 2 2 0 Cytochrome b5-like Heme/Steroid binding domain KRTDAP PF15200.6 CCF45498.1 - 0.12 12.1 0.0 0.15 11.8 0.0 1.1 1 0 0 1 1 1 0 Keratinocyte differentiation-associated Fungal_trans PF04082.18 CCF45500.1 - 1.5e-11 43.8 0.2 2.2e-11 43.3 0.2 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF45500.1 - 5.8e-08 32.7 10.7 1.4e-07 31.5 10.7 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DASH_Hsk3 PF08227.11 CCF45500.1 - 0.2 12.0 1.2 6.2 7.3 0.1 2.6 2 0 0 2 2 2 0 DASH complex subunit Hsk3 like Cu-oxidase_2 PF07731.14 CCF45502.1 - 1.6e-46 157.4 10.7 8.3e-45 151.9 1.4 3.9 3 2 1 4 4 4 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 CCF45502.1 - 1.8e-39 134.4 11.5 1.9e-39 134.3 1.8 3.9 4 0 0 4 4 4 1 Multicopper oxidase Cu-oxidase PF00394.22 CCF45502.1 - 8.8e-34 116.9 3.4 9.2e-34 116.9 0.1 2.8 4 0 0 4 4 4 1 Multicopper oxidase DUF5412 PF17428.2 CCF45502.1 - 0.048 13.5 0.1 0.11 12.3 0.1 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5412) Perilipin PF03036.16 CCF45503.1 - 0.0017 17.5 0.0 0.0018 17.3 0.0 1.1 1 0 0 1 1 1 1 Perilipin family TetR_C_15 PF17918.1 CCF45504.1 - 0.082 13.7 0.1 0.63 10.8 0.0 2.2 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Acyl-CoA_dh_N PF02771.16 CCF45505.1 - 3.7e-21 75.9 0.6 5.8e-21 75.3 0.6 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Nrap PF03813.14 CCF45506.1 - 3.1e-42 144.2 0.0 4.6e-42 143.6 0.0 1.2 1 0 0 1 1 1 1 Nrap protein domain 1 Zn_clus PF00172.18 CCF45507.1 - 1e-08 35.1 10.9 1.6e-08 34.5 10.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 CCF45507.1 - 8.8e-06 24.8 0.0 1.1e-05 24.5 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Cyt-b5 PF00173.28 CCF45508.1 - 4e-10 39.7 0.0 6.2e-10 39.1 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain DUF5056 PF16479.5 CCF45509.1 - 0.15 12.3 0.0 0.31 11.3 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5056) AOX PF01786.17 CCF45511.1 - 2.8e-48 164.3 0.0 3.8e-48 163.9 0.0 1.1 1 0 0 1 1 1 1 Alternative oxidase Pkinase PF00069.25 CCF45512.1 - 3.7e-67 226.5 0.1 5.7e-66 222.6 0.1 2.2 1 1 0 1 1 1 1 Protein kinase domain Fungal_KA1 PF16797.5 CCF45512.1 - 1.5e-39 134.4 0.0 3.1e-39 133.3 0.0 1.6 1 0 0 1 1 1 1 Fungal kinase associated-1 domain Pkinase_Tyr PF07714.17 CCF45512.1 - 8.1e-34 117.1 0.1 2.8e-33 115.3 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF45512.1 - 0.0002 20.8 0.0 0.00034 20.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 CCF45512.1 - 0.00076 19.5 0.0 0.016 15.1 0.0 2.5 1 1 1 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CCF45512.1 - 0.0069 16.0 0.3 0.016 14.8 0.3 1.6 1 0 0 1 1 1 1 Choline/ethanolamine kinase Haspin_kinase PF12330.8 CCF45512.1 - 0.013 14.4 0.0 0.024 13.6 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 CCF45512.1 - 0.033 13.6 0.1 0.072 12.4 0.1 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Malate_synthase PF01274.22 CCF45513.1 - 9.7e-220 730.3 0.0 1.1e-219 730.1 0.0 1.0 1 0 0 1 1 1 1 Malate synthase Phycobilisome PF00502.19 CCF45516.1 - 0.11 12.4 0.0 0.12 12.3 0.0 1.1 1 0 0 1 1 1 0 Phycobilisome protein Glyco_hydro_18 PF00704.28 CCF45519.1 - 6.5e-85 285.6 0.2 7.5e-85 285.4 0.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 DUF4766 PF15973.5 CCF45519.1 - 0.014 16.0 0.4 0.036 14.7 0.4 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4766) DNA_pol_B PF00136.21 CCF45520.1 - 5.7e-15 55.0 0.1 6.4e-15 54.8 0.1 1.1 1 0 0 1 1 1 1 DNA polymerase family B DUF3055 PF11256.8 CCF45520.1 - 0.12 12.6 0.0 0.15 12.4 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3055) GRDP-like PF07173.12 CCF45521.1 - 0.00044 20.9 0.0 0.00086 20.0 0.0 1.5 1 0 0 1 1 1 1 Glycine-rich domain-containing protein-like DZR PF12773.7 CCF45521.1 - 0.14 12.2 3.6 1.1 9.4 1.9 2.3 2 0 0 2 2 2 0 Double zinc ribbon Sugar_tr PF00083.24 CCF45524.1 - 4.7e-06 25.7 0.2 5.4e-06 25.5 0.2 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter DUF2235 PF09994.9 CCF45525.1 - 1.3e-85 287.3 0.3 4.1e-85 285.6 0.3 1.8 1 1 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) DUF521 PF04412.13 CCF45525.1 - 0.09 11.5 0.0 0.15 10.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF521) Hydrolase_4 PF12146.8 CCF45525.1 - 0.098 11.9 0.0 0.17 11.1 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Acyl-CoA_dh_1 PF00441.24 CCF45526.1 - 2.3e-24 86.3 3.1 3.6e-24 85.7 3.1 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 CCF45526.1 - 1.6e-08 35.2 0.2 3.7e-08 34.0 0.2 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 CCF45526.1 - 6.1e-07 29.8 5.7 6.1e-07 29.8 5.7 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 CCF45526.1 - 2.5e-06 27.6 0.0 5.8e-06 26.4 0.0 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Equine_IAV_S2 PF06502.11 CCF45526.1 - 0.0093 16.0 0.0 0.019 15.0 0.0 1.5 1 0 0 1 1 1 1 Equine infectious anaemia virus S2 protein MFS_1 PF07690.16 CCF45527.1 - 2.5e-06 26.6 10.5 2.5e-06 26.6 10.5 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Bac_export_1 PF01311.20 CCF45527.1 - 0.11 12.0 6.6 0.22 11.0 6.6 1.5 1 1 0 1 1 1 0 Bacterial export proteins, family 1 DUF962 PF06127.11 CCF45527.1 - 0.14 12.2 1.7 0.54 10.4 0.4 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF962) Ldr_toxin PF13940.6 CCF45527.1 - 0.73 9.9 6.2 0.17 12.0 1.9 2.2 2 0 0 2 2 2 0 Toxin Ldr, type I toxin-antitoxin system Vfa1 PF08432.10 CCF45528.1 - 0.2 12.0 47.1 0.27 11.5 47.1 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 AAA_11 PF13086.6 CCF45528.1 - 0.26 11.0 39.2 0.32 10.8 39.2 1.1 1 0 0 1 1 1 0 AAA domain ALMT PF11744.8 CCF45528.1 - 0.36 9.6 36.6 0.48 9.2 36.6 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter XRN_M PF17846.1 CCF45528.1 - 0.98 8.3 33.3 1.1 8.1 33.3 1.1 1 0 0 1 1 1 0 Xrn1 helical domain DUF572 PF04502.13 CCF45528.1 - 1.2 8.7 40.0 1.7 8.2 40.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) CDC45 PF02724.14 CCF45528.1 - 3.4 5.8 44.1 3.8 5.7 44.1 1.0 1 0 0 1 1 1 0 CDC45-like protein PA26 PF04636.13 CCF45528.1 - 3.8 6.3 36.8 4.4 6.1 36.8 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Presenilin PF01080.17 CCF45528.1 - 4 6.1 58.1 5.2 5.7 58.1 1.1 1 0 0 1 1 1 0 Presenilin Hid1 PF12722.7 CCF45528.1 - 4.3 5.4 47.0 4.5 5.3 47.0 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RR_TM4-6 PF06459.12 CCF45528.1 - 4.6 7.0 47.9 7.5 6.3 47.9 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Draxin PF15550.6 CCF45528.1 - 8.5 6.1 31.3 9.6 6.0 31.3 1.1 1 0 0 1 1 1 0 Draxin WTX PF09422.10 CCF45528.1 - 8.9 5.3 34.8 10 5.1 34.8 1.0 1 0 0 1 1 1 0 WTX protein FAM60A PF15396.6 CCF45528.1 - 9.5 6.2 38.3 15 5.5 38.3 1.4 1 0 0 1 1 1 0 Protein Family FAM60A Fungal_trans_2 PF11951.8 CCF45529.1 - 1.2e-08 34.2 1.0 2e-08 33.5 1.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Hus1 PF04005.12 CCF45530.1 - 4e-88 295.3 0.0 4.4e-88 295.2 0.0 1.0 1 0 0 1 1 1 1 Hus1-like protein CXCR4_N PF12109.8 CCF45531.1 - 0.12 12.6 0.2 0.21 11.8 0.2 1.3 1 0 0 1 1 1 0 CXCR4 Chemokine receptor N terminal NIPSNAP PF07978.13 CCF45532.1 - 7.8e-24 83.9 0.7 2.3e-12 47.0 0.1 2.6 2 0 0 2 2 2 2 NIPSNAP Uds1 PF15456.6 CCF45532.1 - 0.023 14.8 0.5 0.043 14.0 0.5 1.4 1 0 0 1 1 1 0 Up-regulated During Septation Vma12 PF11712.8 CCF45532.1 - 0.16 12.1 0.4 0.29 11.2 0.4 1.4 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase ASD2 PF08687.11 CCF45532.1 - 2.1 7.8 4.5 6.1 6.3 4.5 1.7 1 1 0 1 1 1 0 Apx/Shroom domain ASD2 SR-25 PF10500.9 CCF45532.1 - 2.1 7.9 13.0 3.1 7.3 13.0 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF2264 PF10022.9 CCF45534.1 - 6.3e-100 334.7 1.2 8.5e-100 334.3 1.2 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2264) GMC_oxred_C PF05199.13 CCF45535.1 - 3.1e-14 53.7 0.3 3.5e-14 53.6 0.3 1.0 1 0 0 1 1 1 1 GMC oxidoreductase Sugar_tr PF00083.24 CCF45536.1 - 6.6e-110 368.1 22.0 1.2e-109 367.2 22.0 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF45536.1 - 5.8e-23 81.4 52.0 2e-16 59.9 27.6 2.6 1 1 2 3 3 3 2 Major Facilitator Superfamily HetR_C PF18460.1 CCF45536.1 - 0.14 12.1 1.0 0.29 11.1 1.0 1.5 1 0 0 1 1 1 0 Heterocyst differentiation regulator C-terminal Hood domain DUF89 PF01937.19 CCF45537.1 - 1.7e-136 454.8 0.0 2e-136 454.6 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF89 adh_short_C2 PF13561.6 CCF45539.1 - 6.2e-30 104.5 0.0 6.4e-30 104.4 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF45539.1 - 1.5e-12 47.3 0.0 1.7e-12 47.2 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase ZapA PF05164.13 CCF45541.1 - 0.012 16.1 0.8 0.022 15.2 0.8 1.6 1 1 0 1 1 1 0 Cell division protein ZapA SOAR PF16533.5 CCF45541.1 - 0.029 14.3 0.6 0.044 13.8 0.6 1.2 1 0 0 1 1 1 0 STIM1 Orai1-activating region HSCB_C PF07743.13 CCF45541.1 - 0.13 12.7 2.4 0.21 12.1 2.4 1.3 1 0 0 1 1 1 0 HSCB C-terminal oligomerisation domain Lactamase_B PF00753.27 CCF45542.1 - 2.7e-18 66.7 0.5 4.5e-16 59.4 0.5 2.1 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CCF45542.1 - 0.00022 20.8 0.4 0.0048 16.4 0.4 2.1 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Peripla_BP_4 PF13407.6 CCF45542.1 - 0.02 14.4 0.4 0.037 13.6 0.4 1.4 1 0 0 1 1 1 0 Periplasmic binding protein domain HAUS-augmin3 PF14932.6 CCF45543.1 - 3.1e-05 23.7 4.8 3.1e-05 23.7 4.8 1.9 2 0 0 2 2 2 1 HAUS augmin-like complex subunit 3 Lebercilin PF15619.6 CCF45543.1 - 0.0004 20.1 5.6 0.0004 20.1 5.6 2.9 3 0 0 3 3 3 1 Ciliary protein causing Leber congenital amaurosis disease bZIP_1 PF00170.21 CCF45543.1 - 0.00075 19.6 9.8 0.0053 16.8 0.5 3.7 2 1 1 3 3 3 1 bZIP transcription factor Fez1 PF06818.15 CCF45543.1 - 0.0014 19.1 5.4 0.0014 19.1 5.4 2.3 3 1 0 3 3 3 1 Fez1 TPR_MLP1_2 PF07926.12 CCF45543.1 - 0.0048 17.0 13.1 0.0069 16.4 8.0 2.5 2 0 0 2 2 2 1 TPR/MLP1/MLP2-like protein Bap31_Bap29_C PF18035.1 CCF45543.1 - 0.0048 16.9 2.4 1.6 8.8 0.2 2.7 2 0 0 2 2 2 1 Bap31/Bap29 cytoplasmic coiled-coil domain CENP-F_leu_zip PF10473.9 CCF45543.1 - 0.0057 16.7 7.6 0.0057 16.7 7.6 2.4 2 1 0 2 2 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Csm1_N PF18504.1 CCF45543.1 - 0.0058 16.9 8.9 2.5 8.5 0.8 4.0 1 1 2 3 3 3 1 Csm1 N-terminal domain MPS2 PF17060.5 CCF45543.1 - 0.0078 15.5 6.2 0.014 14.7 6.2 1.5 1 1 0 1 1 1 1 Monopolar spindle protein 2 HMMR_N PF15905.5 CCF45543.1 - 0.022 14.2 8.9 0.11 12.0 8.9 1.9 1 1 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal DUF724 PF05266.14 CCF45543.1 - 0.039 13.8 6.0 0.051 13.4 5.1 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF724) Atg14 PF10186.9 CCF45543.1 - 0.05 12.7 9.1 0.081 12.0 9.1 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4200 PF13863.6 CCF45543.1 - 0.051 14.0 10.7 0.66 10.4 8.0 3.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) EzrA PF06160.12 CCF45543.1 - 0.06 11.5 6.6 0.13 10.4 6.6 1.6 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA ATG16 PF08614.11 CCF45543.1 - 0.065 13.5 13.6 0.28 11.4 13.6 2.1 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF4201 PF13870.6 CCF45543.1 - 0.07 12.9 7.9 0.53 10.0 7.4 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) DUF4407 PF14362.6 CCF45543.1 - 0.093 12.1 6.5 0.25 10.7 6.5 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TMPIT PF07851.13 CCF45543.1 - 0.1 11.8 1.8 0.22 10.7 1.8 1.6 1 0 0 1 1 1 0 TMPIT-like protein Spc7 PF08317.11 CCF45543.1 - 0.17 10.7 13.3 0.029 13.3 8.1 2.0 2 1 1 3 3 2 0 Spc7 kinetochore protein Cut12 PF11500.8 CCF45543.1 - 0.19 11.7 5.0 0.21 11.5 2.3 2.2 1 1 1 2 2 2 0 Spindle pole body formation-associated protein PKcGMP_CC PF16808.5 CCF45543.1 - 0.24 11.3 7.0 3.9 7.4 0.3 3.9 3 0 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Mod_r PF07200.13 CCF45543.1 - 0.3 11.2 15.9 1.3 9.1 6.7 3.1 2 1 1 3 3 3 0 Modifier of rudimentary (Mod(r)) protein ADIP PF11559.8 CCF45543.1 - 0.31 11.1 11.6 12 5.9 11.0 2.8 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF1192 PF06698.11 CCF45543.1 - 0.33 11.0 6.7 5.7 7.1 0.1 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) GrpE PF01025.19 CCF45543.1 - 0.46 10.1 9.2 2.2 7.9 2.7 2.8 2 1 1 3 3 3 0 GrpE BLOC1_2 PF10046.9 CCF45543.1 - 0.53 10.6 4.9 0.34 11.2 1.7 2.5 2 1 0 2 2 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TMF_DNA_bd PF12329.8 CCF45543.1 - 0.54 10.3 14.1 1.1 9.3 0.5 3.6 3 1 1 4 4 4 0 TATA element modulatory factor 1 DNA binding DUF5082 PF16888.5 CCF45543.1 - 0.64 10.3 6.3 14 6.0 0.4 3.4 1 1 2 3 3 3 0 Domain of unknown function (DUF5082) Shugoshin_N PF07558.11 CCF45543.1 - 0.7 9.8 5.5 0.15 11.9 0.9 2.2 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region OmpH PF03938.14 CCF45543.1 - 0.72 10.2 8.7 0.36 11.2 5.7 2.0 2 0 0 2 2 1 0 Outer membrane protein (OmpH-like) DivIC PF04977.15 CCF45543.1 - 1.2 9.0 13.8 1.6 8.6 2.6 3.6 2 1 1 3 3 3 0 Septum formation initiator ERM PF00769.19 CCF45543.1 - 1.3 8.8 15.2 0.18 11.6 11.0 1.8 2 0 0 2 2 1 0 Ezrin/radixin/moesin family DUF641 PF04859.12 CCF45543.1 - 1.7 9.0 11.4 2.2 8.6 2.6 3.3 2 1 1 3 3 3 0 Plant protein of unknown function (DUF641) CtIP_N PF10482.9 CCF45543.1 - 2.3 8.3 9.0 16 5.6 8.7 2.4 1 1 1 2 2 2 0 Tumour-suppressor protein CtIP N-terminal domain Prefoldin_2 PF01920.20 CCF45543.1 - 3.4 7.7 8.7 1.1 9.2 1.1 3.0 2 1 1 3 3 2 0 Prefoldin subunit FAM76 PF16046.5 CCF45543.1 - 3.5 6.9 7.4 1 8.6 0.6 2.3 1 1 0 2 2 2 0 FAM76 protein ZapB PF06005.12 CCF45543.1 - 4.7 7.7 19.7 12 6.4 9.0 4.1 2 1 2 4 4 3 0 Cell division protein ZapB HIP1_clath_bdg PF16515.5 CCF45543.1 - 4.8 7.8 15.6 6.6 7.4 9.3 3.4 2 1 1 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 CLZ PF16526.5 CCF45543.1 - 4.9 7.6 11.1 0.35 11.3 0.9 3.6 2 1 1 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels UPF0242 PF06785.11 CCF45543.1 - 7 6.7 16.1 1.8 8.6 12.1 2.0 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus PUF PF00806.19 CCF45544.1 - 2.8e-13 48.8 0.1 0.032 13.9 0.0 5.4 5 0 0 5 5 5 5 Pumilio-family RNA binding repeat Glyco_transf_88 PF16849.5 CCF45545.1 - 0.24 10.3 0.1 0.27 10.1 0.1 1.0 1 0 0 1 1 1 0 Glycosyltransferase family 88 Gemini_AL1_M PF08283.11 CCF45546.1 - 4.9e-05 23.4 0.0 0.0002 21.4 0.0 1.9 2 0 0 2 2 2 1 Geminivirus rep protein central domain PTCB-BRCT PF12738.7 CCF45546.1 - 0.12 12.3 0.0 0.29 11.1 0.0 1.6 1 0 0 1 1 1 0 twin BRCT domain Sec2p PF06428.11 CCF45547.1 - 0.00015 21.6 4.6 0.00027 20.8 4.6 1.3 1 0 0 1 1 1 1 GDP/GTP exchange factor Sec2p MPS2 PF17060.5 CCF45547.1 - 0.00027 20.3 0.2 0.00041 19.7 0.2 1.2 1 0 0 1 1 1 1 Monopolar spindle protein 2 Apolipoprotein PF01442.18 CCF45547.1 - 0.0014 18.6 3.5 0.0023 17.9 3.5 1.4 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain CC2-LZ PF16516.5 CCF45547.1 - 0.004 17.5 2.8 0.0071 16.7 2.8 1.3 1 0 0 1 1 1 1 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator BicD PF09730.9 CCF45547.1 - 0.0045 15.5 2.9 0.0067 14.9 2.9 1.3 1 0 0 1 1 1 1 Microtubule-associated protein Bicaudal-D Spc7 PF08317.11 CCF45547.1 - 0.0078 15.1 1.6 0.011 14.6 1.6 1.3 1 0 0 1 1 1 1 Spc7 kinetochore protein HrpB7 PF09486.10 CCF45547.1 - 0.013 15.9 1.1 0.025 15.0 1.1 1.5 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) Fez1 PF06818.15 CCF45547.1 - 0.17 12.3 5.7 0.16 12.4 3.9 1.8 1 1 0 1 1 1 0 Fez1 FAM76 PF16046.5 CCF45547.1 - 0.17 11.2 13.8 0.48 9.7 13.8 1.9 1 1 0 1 1 1 0 FAM76 protein MscS_porin PF12795.7 CCF45547.1 - 0.19 11.2 12.3 0.41 10.2 11.9 1.7 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain SBP_bac_6 PF13343.6 CCF45548.1 - 9.8e-11 41.5 0.8 1.4e-10 41.0 0.8 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_8 PF13416.6 CCF45548.1 - 5.8e-09 36.2 1.4 1.3e-08 35.1 1.4 1.5 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_11 PF13531.6 CCF45548.1 - 0.00011 22.0 0.0 0.00016 21.5 0.0 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 CCF45548.1 - 0.019 15.0 4.6 0.048 13.6 4.6 1.7 1 1 0 1 1 1 0 Bacterial extracellular solute-binding protein Ank_2 PF12796.7 CCF45549.1 - 1.5e-17 64.0 0.3 8.6e-12 45.5 0.0 4.7 4 1 1 5 5 5 3 Ankyrin repeats (3 copies) Ank PF00023.30 CCF45549.1 - 8.3e-11 41.8 3.0 0.0075 16.7 0.0 4.5 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 CCF45549.1 - 1e-07 32.1 1.1 0.0086 16.4 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 CCF45549.1 - 1.4e-06 28.8 0.5 0.0095 16.5 0.0 4.6 2 1 2 4 4 4 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCF45549.1 - 5.3e-06 26.4 0.9 1.6 9.5 0.0 5.4 6 1 0 6 6 6 2 Ankyrin repeat NACHT PF05729.12 CCF45549.1 - 0.00022 21.2 2.1 0.0014 18.6 0.4 2.8 2 1 0 2 2 2 1 NACHT domain TsaE PF02367.17 CCF45549.1 - 0.016 15.2 0.0 0.042 13.9 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATP12 PF07542.11 CCF45551.1 - 4.9e-27 94.6 0.1 8.8e-27 93.7 0.1 1.4 1 0 0 1 1 1 1 ATP12 chaperone protein DFP PF04127.15 CCF45552.1 - 0.0044 16.9 0.2 0.006 16.4 0.2 1.2 1 0 0 1 1 1 1 DNA / pantothenate metabolism flavoprotein MFS_1 PF07690.16 CCF45554.1 - 5.5e-13 48.6 19.3 5.5e-13 48.6 19.3 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF45554.1 - 0.0015 17.5 16.3 0.0015 17.5 16.3 1.7 1 1 0 1 1 1 1 Sugar (and other) transporter PX PF00787.24 CCF45555.1 - 7.3e-22 77.5 0.2 7.3e-22 77.5 0.2 1.7 2 0 0 2 2 2 1 PX domain Vps5 PF09325.10 CCF45555.1 - 0.0015 18.1 1.0 0.0025 17.4 1.0 1.5 1 1 0 1 1 1 1 Vps5 C terminal like Occludin_ELL PF07303.13 CCF45555.1 - 0.012 16.3 0.1 0.076 13.7 0.0 2.4 1 1 0 2 2 2 0 Occludin homology domain Sec34 PF04136.15 CCF45555.1 - 0.062 13.2 0.1 0.14 12.1 0.1 1.6 1 0 0 1 1 1 0 Sec34-like family Zip PF02535.22 CCF45556.1 - 2.2e-50 171.8 0.0 4.5e-50 170.8 0.0 1.4 1 1 0 1 1 1 1 ZIP Zinc transporter KIF1B PF12423.8 CCF45556.1 - 0.21 12.1 0.4 0.46 11.0 0.4 1.5 1 0 0 1 1 1 0 Kinesin protein 1B Glyco_hydro_61 PF03443.14 CCF45557.1 - 0.0071 16.3 0.1 0.013 15.4 0.1 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 GGACT PF06094.12 CCF45558.1 - 4.9e-15 56.2 0.2 7.8e-15 55.5 0.1 1.4 1 1 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like Stb3 PF10330.9 CCF45559.1 - 1.1e-37 128.0 0.0 1.7e-37 127.3 0.0 1.3 1 0 0 1 1 1 1 Putative Sin3 binding protein SF1-HH PF16275.5 CCF45559.1 - 0.00028 21.2 0.1 0.00064 20.0 0.1 1.5 1 0 0 1 1 1 1 Splicing factor 1 helix-hairpin domain NnrS PF05940.12 CCF45559.1 - 0.21 10.9 0.3 1.4 8.2 0.0 1.9 2 0 0 2 2 2 0 NnrS protein DNA_pol_phi PF04931.13 CCF45559.1 - 2.1 6.4 4.1 2.7 6.0 4.1 1.0 1 0 0 1 1 1 0 DNA polymerase phi NmrA PF05368.13 CCF45560.1 - 3.7e-30 105.2 0.0 6.7e-30 104.4 0.0 1.4 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CCF45560.1 - 1.5e-10 41.3 0.1 2e-10 40.8 0.1 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CCF45560.1 - 0.00019 21.0 0.0 0.00028 20.4 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family adh_short PF00106.25 CCF45560.1 - 0.00082 18.9 0.1 0.0014 18.1 0.1 1.4 1 0 0 1 1 1 1 short chain dehydrogenase GDP_Man_Dehyd PF16363.5 CCF45560.1 - 0.012 15.1 0.0 0.041 13.3 0.0 1.8 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase F420_oxidored PF03807.17 CCF45560.1 - 0.035 14.7 0.1 0.064 13.8 0.1 1.4 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent adh_short_C2 PF13561.6 CCF45561.1 - 6.1e-48 163.4 0.9 7.2e-48 163.2 0.9 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF45561.1 - 2e-38 131.8 0.2 2.5e-38 131.5 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF45561.1 - 5.7e-09 36.1 0.6 8.2e-09 35.6 0.6 1.2 1 0 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 CCF45561.1 - 0.075 12.9 0.4 0.1 12.5 0.4 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF1419 PF07215.11 CCF45561.1 - 0.11 12.6 0.0 0.22 11.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1419) Eno-Rase_NADH_b PF12242.8 CCF45561.1 - 0.15 11.8 0.5 0.32 10.8 0.5 1.5 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Hydantoinase_A PF01968.18 CCF45562.1 - 1.2e-67 228.3 1.1 3.6e-67 226.7 0.1 2.0 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 CCF45562.1 - 9.8e-57 191.5 0.3 1.3e-54 184.6 0.0 2.2 2 0 0 2 2 2 2 Hydantoinase/oxoprolinase N-terminal region GDP_Man_Dehyd PF16363.5 CCF45563.1 - 5.9e-36 124.5 0.0 7.2e-36 124.2 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 CCF45563.1 - 1.2e-30 106.8 0.0 1.5e-30 106.4 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 CCF45563.1 - 3.8e-07 29.5 0.0 4.5e-07 29.3 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein RmlD_sub_bind PF04321.17 CCF45563.1 - 6.7e-07 28.7 0.0 7.7e-07 28.5 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 CCF45563.1 - 9.9e-05 21.6 0.0 0.00013 21.2 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 CCF45563.1 - 0.028 13.4 0.0 0.037 13.0 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family DUF2870 PF11069.8 CCF45564.1 - 0.0075 16.6 0.3 5.1 7.6 0.0 3.0 2 0 0 2 2 2 2 Protein of unknown function (DUF2870) Syntaxin-6_N PF09177.11 CCF45564.1 - 0.67 10.5 8.0 1 10.0 0.3 3.1 2 1 1 3 3 3 0 Syntaxin 6, N-terminal Bac_globin PF01152.21 CCF45565.1 - 0.52 10.4 4.7 1.1 9.4 2.9 2.3 2 1 1 3 3 3 0 Bacterial-like globin Pkinase PF00069.25 CCF45566.1 - 0.0013 18.2 0.0 0.14 11.5 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain PDEase_II PF02112.15 CCF45569.1 - 4.9e-49 167.3 0.2 3.2e-41 141.6 0.1 2.8 2 1 0 2 2 2 2 cAMP phosphodiesterases class-II Abhydrolase_1 PF00561.20 CCF45570.1 - 0.0079 15.9 0.0 0.014 15.0 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCF45570.1 - 0.087 13.4 0.7 0.13 12.9 0.7 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Pkinase PF00069.25 CCF45571.1 - 2.2e-09 37.1 0.0 2.9e-09 36.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF45571.1 - 0.007 15.7 0.0 0.0099 15.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF45571.1 - 0.18 11.1 0.0 0.25 10.6 0.0 1.1 1 0 0 1 1 1 0 Kinase-like XPG_I PF00867.18 CCF45572.1 - 6.2e-27 93.8 0.6 1.6e-26 92.5 0.0 2.1 2 0 0 2 2 2 1 XPG I-region 5_3_exonuc PF01367.20 CCF45572.1 - 0.013 16.0 0.1 0.07 13.7 0.0 2.3 2 0 0 2 2 2 0 5'-3' exonuclease, C-terminal SAM fold DUF1943 PF09172.11 CCF45572.1 - 0.038 13.2 0.1 0.072 12.3 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1943) HHH PF00633.23 CCF45572.1 - 0.13 12.2 0.1 0.51 10.3 0.1 2.1 1 0 0 1 1 1 0 Helix-hairpin-helix motif DUF2229 PF09989.9 CCF45572.1 - 0.84 9.2 2.8 0.5 10.0 0.2 1.9 3 0 0 3 3 3 0 CoA enzyme activase uncharacterised domain (DUF2229) adh_short PF00106.25 CCF45574.1 - 1.4e-31 109.5 0.6 3.6e-31 108.1 0.6 1.7 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF45574.1 - 5.8e-25 88.2 4.1 1.5e-22 80.3 4.1 2.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.6 CCF45574.1 - 1.1e-05 25.4 0.0 2.3e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 NAD(P)H-binding DUF1776 PF08643.10 CCF45574.1 - 0.00013 21.5 0.0 0.00022 20.7 0.0 1.3 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) NmrA PF05368.13 CCF45574.1 - 0.00016 21.3 0.0 0.00031 20.4 0.0 1.5 1 0 0 1 1 1 1 NmrA-like family NAD_binding_2 PF03446.15 CCF45574.1 - 0.0004 20.6 0.1 0.001 19.3 0.0 1.7 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase Epimerase PF01370.21 CCF45574.1 - 0.0011 18.5 0.0 0.0018 17.8 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DFP PF04127.15 CCF45574.1 - 0.0022 17.9 0.2 0.0039 17.0 0.2 1.4 1 0 0 1 1 1 1 DNA / pantothenate metabolism flavoprotein ApbA PF02558.16 CCF45574.1 - 0.068 12.8 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA PP-binding PF00550.25 CCF45575.1 - 3e-07 30.7 0.0 3.8e-07 30.4 0.0 1.2 1 0 0 1 1 1 1 Phosphopantetheine attachment site p450 PF00067.22 CCF45576.1 - 1.1e-57 195.8 0.0 1.3e-57 195.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 RTA1 PF04479.13 CCF45577.1 - 1.5e-06 28.0 0.4 1.9e-06 27.6 0.4 1.2 1 0 0 1 1 1 1 RTA1 like protein NAD_binding_11 PF14833.6 CCF45578.1 - 2.7e-28 98.7 0.0 3.1e-28 98.4 0.0 1.0 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Brix PF04427.18 CCF45580.1 - 4.5e-35 121.5 0.0 7e-35 120.9 0.0 1.2 1 0 0 1 1 1 1 Brix domain Rho_RNA_bind PF07497.12 CCF45580.1 - 0.019 14.8 0.1 0.052 13.4 0.1 1.6 1 0 0 1 1 1 0 Rho termination factor, RNA-binding domain DUF1072 PF06380.11 CCF45581.1 - 2 8.3 6.3 0.26 11.2 1.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1072) ABC_tran PF00005.27 CCF45582.1 - 4.4e-46 156.8 0.0 1.4e-24 87.1 0.0 2.4 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 CCF45582.1 - 1.7e-34 119.8 16.8 1.1e-23 84.3 9.0 2.5 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 CCF45582.1 - 9.5e-11 41.6 0.2 0.00016 21.2 0.0 4.2 4 0 0 4 4 4 3 RecF/RecN/SMC N terminal domain T2SSE PF00437.20 CCF45582.1 - 6.3e-08 32.0 0.1 0.00013 21.2 0.0 2.4 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_29 PF13555.6 CCF45582.1 - 2.2e-06 27.3 2.5 0.057 13.2 0.3 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.6 CCF45582.1 - 2.6e-06 27.5 1.4 0.053 13.3 0.1 4.0 3 1 1 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 CCF45582.1 - 1.2e-05 25.6 0.3 0.11 12.8 0.1 3.0 2 1 0 2 2 2 2 AAA domain AAA_16 PF13191.6 CCF45582.1 - 8.5e-05 23.0 0.5 0.0088 16.4 0.1 2.7 2 0 0 2 2 2 1 AAA ATPase domain NB-ARC PF00931.22 CCF45582.1 - 8.7e-05 21.8 0.2 0.01 15.0 0.0 2.6 3 0 0 3 3 3 1 NB-ARC domain RsgA_GTPase PF03193.16 CCF45582.1 - 0.00069 19.6 0.1 0.46 10.4 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_7 PF12775.7 CCF45582.1 - 0.00079 19.0 0.2 0.2 11.2 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_25 PF13481.6 CCF45582.1 - 0.0011 18.6 0.2 0.33 10.5 0.0 3.0 3 0 0 3 3 3 1 AAA domain AAA_23 PF13476.6 CCF45582.1 - 0.0013 19.2 0.4 2.2 8.7 0.1 2.3 2 0 0 2 2 2 2 AAA domain FtsK_SpoIIIE PF01580.18 CCF45582.1 - 0.0051 16.2 1.0 0.17 11.2 0.0 2.3 2 0 0 2 2 2 1 FtsK/SpoIIIE family MMR_HSR1 PF01926.23 CCF45582.1 - 0.0082 16.2 0.0 1.5 8.9 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase DEAD PF00270.29 CCF45582.1 - 0.011 15.5 1.2 8.2 6.2 0.0 3.4 4 0 0 4 4 4 0 DEAD/DEAH box helicase ATP_bind_1 PF03029.17 CCF45582.1 - 0.013 15.3 0.0 4.9 6.9 0.0 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein cobW PF02492.19 CCF45582.1 - 0.014 15.0 1.3 3.8 7.1 0.2 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain DUF87 PF01935.17 CCF45582.1 - 0.038 14.1 1.2 0.59 10.2 0.1 2.3 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_33 PF13671.6 CCF45582.1 - 0.045 13.9 0.0 12 6.0 0.0 2.6 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 CCF45582.1 - 0.071 12.8 0.0 14 5.4 0.0 2.4 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase TrwB_AAD_bind PF10412.9 CCF45582.1 - 0.073 12.0 0.6 0.91 8.4 0.1 2.1 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain IstB_IS21 PF01695.17 CCF45582.1 - 0.087 12.6 0.2 10 5.8 0.0 3.5 4 0 0 4 4 4 0 IstB-like ATP binding protein NTPase_1 PF03266.15 CCF45582.1 - 0.092 12.7 1.6 25 4.7 0.0 3.4 4 0 0 4 4 3 0 NTPase NACHT PF05729.12 CCF45582.1 - 0.096 12.6 1.7 3.6 7.5 0.0 3.2 4 0 0 4 4 2 0 NACHT domain Rad17 PF03215.15 CCF45582.1 - 0.24 11.3 0.2 1.6 8.6 0.1 2.1 2 0 0 2 2 2 0 Rad17 P-loop domain PIG-Y PF15159.6 CCF45582.1 - 4.5 8.3 9.7 41 5.2 5.6 3.3 2 0 0 2 2 2 0 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y adh_short PF00106.25 CCF45583.1 - 4.5e-23 81.7 0.0 6.2e-23 81.3 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF45583.1 - 5.7e-15 55.5 0.0 8.1e-15 55.0 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF45583.1 - 1.8e-08 34.5 0.2 3.9e-08 33.4 0.1 1.5 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 CCF45583.1 - 0.00058 19.4 0.1 0.00099 18.6 0.1 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 CCF45583.1 - 0.0051 16.0 0.0 0.0066 15.6 0.0 1.3 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein Glyco_tran_WecB PF03808.13 CCF45583.1 - 0.1 12.6 0.0 0.63 10.0 0.0 2.2 3 0 0 3 3 3 0 Glycosyl transferase WecB/TagA/CpsF family Sacchrp_dh_NADP PF03435.18 CCF45583.1 - 0.15 12.4 0.0 0.21 11.8 0.0 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain TauD PF02668.16 CCF45586.1 - 5.1e-62 210.1 0.6 6.3e-62 209.8 0.6 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Carn_acyltransf PF00755.20 CCF45587.1 - 6.2e-17 61.5 1.0 7.4e-17 61.2 1.0 1.1 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase FdhD-NarQ PF02634.15 CCF45587.1 - 0.2 11.3 0.0 0.24 11.0 0.0 1.1 1 0 0 1 1 1 0 FdhD/NarQ family Catalase_C PF18011.1 CCF45588.1 - 5.4e-47 159.2 0.2 7.9e-47 158.7 0.2 1.2 1 0 0 1 1 1 1 C-terminal domain found in long catalases Catalase-rel PF06628.12 CCF45588.1 - 9.8e-21 73.7 0.0 1.7e-20 73.0 0.0 1.4 1 0 0 1 1 1 1 Catalase-related immune-responsive PALP PF00291.25 CCF45589.1 - 0.07 12.5 0.0 0.088 12.2 0.0 1.2 1 0 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme SMP PF04927.12 CCF45590.1 - 8.4e-05 23.0 3.2 0.00015 22.2 3.2 1.4 1 0 0 1 1 1 1 Seed maturation protein Ank_4 PF13637.6 CCF45591.1 - 0.15 12.7 0.0 0.28 11.8 0.0 1.4 1 0 0 1 1 1 0 Ankyrin repeats (many copies) Thioredoxin PF00085.20 CCF45592.1 - 4.5e-43 145.4 0.2 4.4e-24 84.4 0.0 3.4 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.6 CCF45592.1 - 4.4e-09 36.5 0.0 0.00082 19.3 0.0 3.6 1 1 2 3 3 3 3 Thioredoxin-like domain Thioredoxin_2 PF13098.6 CCF45592.1 - 2.6e-05 24.6 2.1 0.12 12.8 0.1 3.5 3 1 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 CCF45592.1 - 0.00022 21.5 0.2 0.068 13.5 0.0 3.9 3 1 0 3 3 3 1 Thioredoxin-like Thioredoxin_7 PF13899.6 CCF45592.1 - 0.0014 18.7 0.3 0.061 13.5 0.1 3.2 3 0 0 3 3 3 1 Thioredoxin-like AhpC-TSA PF00578.21 CCF45592.1 - 0.0058 16.5 0.6 0.068 13.1 0.0 2.9 3 0 0 3 3 3 1 AhpC/TSA family OST3_OST6 PF04756.13 CCF45592.1 - 0.036 13.4 0.1 2.6 7.3 0.0 2.5 2 0 0 2 2 2 0 OST3 / OST6 family, transporter family CCDC53 PF10152.9 CCF45592.1 - 0.39 11.1 2.1 1.1 9.7 2.1 1.7 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Thioredoxin_3 PF13192.6 CCF45592.1 - 0.48 10.5 2.1 1.6 8.8 0.0 2.9 5 0 0 5 5 5 0 Thioredoxin domain PLDc_2 PF13091.6 CCF45593.1 - 8.6e-17 61.3 0.0 3.8e-06 26.8 0.0 3.9 3 1 0 3 3 3 3 PLD-like domain PLDc PF00614.22 CCF45593.1 - 2.1e-11 43.5 0.8 6.5e-05 22.9 0.1 2.7 2 0 0 2 2 2 2 Phospholipase D Active site motif Acetyltransf_1 PF00583.25 CCF45594.1 - 3.7e-07 30.4 0.0 1e-06 29.0 0.0 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CCF45594.1 - 1.1e-05 25.3 0.1 0.00026 20.9 0.0 2.3 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CCF45594.1 - 1.2e-05 25.7 0.1 3.9e-05 24.0 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CCF45594.1 - 0.0072 16.3 0.1 0.042 13.8 0.1 2.0 1 1 0 1 1 1 1 FR47-like protein p450 PF00067.22 CCF45595.1 - 1.1e-25 90.4 0.0 1.6e-25 89.8 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 Alk_phosphatase PF00245.20 CCF45597.1 - 2.9e-90 303.2 0.0 3.7e-90 302.9 0.0 1.0 1 0 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.18 CCF45597.1 - 0.00015 21.2 0.0 0.00025 20.5 0.0 1.3 1 0 0 1 1 1 1 Metalloenzyme superfamily RskA PF10099.9 CCF45597.1 - 0.028 14.7 0.3 0.047 14.0 0.3 1.4 1 0 0 1 1 1 0 Anti-sigma-K factor rskA MTABC_N PF16185.5 CCF45598.1 - 0.053 13.0 0.3 0.25 10.8 0.3 2.1 1 1 0 1 1 1 0 Mitochondrial ABC-transporter N-terminal five TM region DUF4231 PF14015.6 CCF45598.1 - 0.24 11.9 2.6 0.35 11.3 0.2 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF4231) YesK PF14150.6 CCF45598.1 - 0.26 11.5 3.5 1.2 9.4 0.4 2.3 2 0 0 2 2 2 0 YesK-like protein DUF484 PF04340.12 CCF45599.1 - 0.14 11.9 0.1 0.25 11.0 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF484 HECT PF00632.25 CCF45600.1 - 7.1e-66 222.8 0.0 9.9e-66 222.3 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) 2OG-FeII_Oxy_3 PF13640.6 CCF45601.1 - 5.7e-09 36.8 0.0 9.9e-09 36.0 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF218 PF02698.17 CCF45603.1 - 4.2e-07 30.0 0.0 6e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 DUF218 domain Tyrosinase PF00264.20 CCF45604.1 - 1.4e-36 126.9 0.7 2.8e-36 125.9 0.7 1.4 1 1 0 1 1 1 1 Common central domain of tyrosinase DUF3328 PF11807.8 CCF45605.1 - 0.014 15.2 0.3 0.023 14.5 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3328) HCV_NS5a_C PF12941.7 CCF45605.1 - 0.087 12.7 0.8 0.12 12.3 0.8 1.1 1 0 0 1 1 1 0 HCV NS5a protein C-terminal region Mannosyl_trans3 PF11051.8 CCF45606.1 - 1.4e-53 182.0 0.0 4.7e-53 180.3 0.0 1.8 1 1 0 1 1 1 1 Mannosyltransferase putative p47_phox_C PF08944.11 CCF45606.1 - 0.087 12.3 1.1 0.17 11.3 1.1 1.4 1 0 0 1 1 1 0 NADPH oxidase subunit p47Phox, C terminal domain p450 PF00067.22 CCF45607.1 - 4.6e-18 65.2 0.0 6.4e-18 64.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 C166 PF17615.2 CCF45608.1 - 2.7e-24 86.1 10.2 3.1e-24 85.9 10.2 1.1 1 0 0 1 1 1 1 Family of unknown function HsbA PF12296.8 CCF45608.1 - 0.00084 19.8 1.6 0.0094 16.4 0.9 2.1 1 1 1 2 2 2 1 Hydrophobic surface binding protein A DUF4188 PF13826.6 CCF45610.1 - 3.6e-34 117.6 0.6 5e-34 117.2 0.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4188) Dehydratase_hem PF13816.6 CCF45610.1 - 7.3e-05 22.3 0.6 0.00015 21.3 0.6 1.3 1 1 0 1 1 1 1 Haem-containing dehydratase Prog_receptor PF02161.15 CCF45611.1 - 0.16 10.6 0.1 0.2 10.4 0.1 1.1 1 0 0 1 1 1 0 Progesterone receptor Iso_dh PF00180.20 CCF45613.1 - 1e-131 439.2 0.0 1.2e-131 439.0 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase MFS_1 PF07690.16 CCF45615.1 - 1.9e-06 27.0 25.4 5.2e-05 22.3 25.4 1.9 1 1 0 1 1 1 1 Major Facilitator Superfamily Cyt-b5 PF00173.28 CCF45620.1 - 0.0014 18.8 0.1 0.0025 17.9 0.1 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain MIF4G_like_2 PF09090.11 CCF45620.1 - 0.16 11.4 0.4 0.25 10.8 0.4 1.4 1 1 0 1 1 1 0 MIF4G like Fungal_trans PF04082.18 CCF45623.1 - 9.1e-21 74.1 0.1 1.2e-20 73.6 0.1 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Maf_N PF08383.11 CCF45623.1 - 0.13 12.1 1.1 8 6.3 0.1 2.5 2 0 0 2 2 2 0 Maf N-terminal region adh_short PF00106.25 CCF45626.1 - 2.7e-23 82.5 0.2 5.2e-22 78.3 0.2 2.0 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF45626.1 - 3.8e-16 59.3 0.0 6.1e-15 55.4 0.0 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF45626.1 - 0.003 17.5 0.4 0.0061 16.5 0.4 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF45626.1 - 0.041 13.3 0.3 0.14 11.6 0.3 1.7 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Homeobox_KN PF05920.11 CCF45627.1 - 7.6e-16 57.7 2.5 1.7e-15 56.6 2.5 1.6 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 CCF45627.1 - 8.5e-10 38.3 1.2 1.5e-09 37.5 1.2 1.3 1 0 0 1 1 1 1 Homeodomain Homez PF11569.8 CCF45627.1 - 0.0082 15.6 0.4 0.048 13.1 0.4 2.2 1 1 0 1 1 1 1 Homeodomain leucine-zipper encoding, Homez Pkinase_C PF00433.24 CCF45628.1 - 0.039 14.7 0.4 1.8 9.3 0.5 2.2 2 0 0 2 2 2 0 Protein kinase C terminal domain Acetyltransf_1 PF00583.25 CCF45629.1 - 3.1e-06 27.4 0.0 6.2e-06 26.4 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Rop PF01815.16 CCF45633.1 - 0.23 11.4 0.4 1 9.3 0.3 2.0 2 1 0 2 2 2 0 Rop protein GWT1 PF06423.12 CCF45635.1 - 5.5e-45 153.1 0.8 5.5e-45 153.1 0.8 1.9 2 0 0 2 2 2 1 GWT1 DUF4818 PF16089.5 CCF45635.1 - 0.00077 19.9 0.6 0.0038 17.7 0.0 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4818) Trehalose_PPase PF02358.16 CCF45637.1 - 9.9e-22 77.2 0.0 1.2e-21 76.9 0.0 1.1 1 0 0 1 1 1 1 Trehalose-phosphatase Prenyltrans PF00432.21 CCF45638.1 - 4.3e-33 112.7 7.0 3.8e-07 29.7 0.1 5.8 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat MFS_1 PF07690.16 CCF45639.1 - 2.4e-22 79.3 39.3 3.2e-22 78.9 39.3 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Fungal_trans PF04082.18 CCF45640.1 - 4.7e-14 52.0 0.0 8e-14 51.3 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF45640.1 - 0.00016 21.8 11.2 0.00038 20.5 11.2 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain adh_short_C2 PF13561.6 CCF45642.1 - 3.6e-57 193.6 0.0 4e-57 193.4 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF45642.1 - 4.3e-44 150.3 0.0 5.7e-44 149.9 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF45642.1 - 3.6e-06 27.0 0.1 5.5e-06 26.4 0.1 1.2 1 0 0 1 1 1 1 KR domain Ldh_1_N PF00056.23 CCF45642.1 - 0.0019 18.3 0.0 0.0049 17.0 0.1 1.6 2 0 0 2 2 2 1 lactate/malate dehydrogenase, NAD binding domain HHH_5 PF14520.6 CCF45642.1 - 0.12 13.0 0.3 0.39 11.4 0.1 1.9 2 0 0 2 2 2 0 Helix-hairpin-helix domain Pkinase PF00069.25 CCF45643.1 - 7.4e-45 153.4 0.0 4.4e-44 150.8 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF45643.1 - 4e-31 108.3 0.0 5.7e-31 107.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF45643.1 - 0.002 17.5 0.0 0.0029 17.0 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 CCF45643.1 - 0.011 14.6 0.0 0.016 14.0 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Kdo PF06293.14 CCF45643.1 - 0.026 13.9 0.0 0.27 10.6 0.0 2.1 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CCF45643.1 - 0.12 12.3 0.1 0.43 10.5 0.0 2.0 2 0 0 2 2 2 0 Phosphotransferase enzyme family LIAS_N PF16881.5 CCF45643.1 - 0.13 12.7 0.0 0.65 10.4 0.0 2.0 2 0 0 2 2 2 0 N-terminal domain of lipoyl synthase of Radical_SAM family LRR_6 PF13516.6 CCF45645.1 - 0.015 15.3 0.0 20 5.6 0.0 4.3 5 0 0 5 5 5 0 Leucine Rich repeat CSD2 PF17876.1 CCF45646.1 - 0.11 12.6 0.1 0.38 10.9 0.1 1.9 1 0 0 1 1 1 0 Cold shock domain Y_phosphatase PF00102.27 CCF45649.1 - 1.9e-45 155.3 0.0 3.4e-45 154.5 0.0 1.4 1 1 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 CCF45649.1 - 0.0071 16.3 0.0 0.01 15.8 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 CCF45649.1 - 0.012 15.7 0.0 0.026 14.6 0.0 1.6 1 0 0 1 1 1 0 Inositol hexakisphosphate DSPc PF00782.20 CCF45649.1 - 0.035 13.9 0.0 0.072 12.9 0.0 1.4 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain SARAF PF06682.12 CCF45649.1 - 0.5 10.0 2.3 0.69 9.5 2.3 1.2 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Transp_cyt_pur PF02133.15 CCF45650.1 - 2.1e-27 96.0 0.4 2.6e-27 95.7 0.4 1.1 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Ferric_reduct PF01794.19 CCF45652.1 - 2.5e-19 69.6 17.3 2.5e-19 69.6 17.3 2.1 2 0 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 CCF45652.1 - 0.0019 18.2 0.1 0.022 14.9 0.1 2.4 1 1 0 1 1 1 1 FAD-binding domain Dehydrin PF00257.19 CCF45652.1 - 0.028 15.0 6.4 0.071 13.7 2.2 2.3 2 0 0 2 2 2 0 Dehydrin GPR_Gpa2_C PF11970.8 CCF45652.1 - 0.15 12.2 1.9 1.2 9.2 0.2 2.7 1 1 1 2 2 2 0 G protein-coupled glucose receptor regulating Gpa2 C-term IMUP PF15761.5 CCF45652.1 - 0.76 10.5 14.4 2.3 8.9 0.4 2.4 2 0 0 2 2 2 0 Immortalisation up-regulated protein ERG4_ERG24 PF01222.17 CCF45653.1 - 3.3e-144 480.8 16.0 3.9e-144 480.6 16.0 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family Fungal_trans_2 PF11951.8 CCF45654.1 - 1.2e-08 34.2 0.8 2.4e-08 33.2 0.8 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Methyltransf_23 PF13489.6 CCF45655.1 - 1.6e-21 76.8 0.0 2.4e-21 76.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF45655.1 - 4.2e-11 43.4 0.0 9.1e-11 42.3 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF45655.1 - 5.3e-10 39.8 0.0 9.7e-10 39.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF45655.1 - 1.3e-08 34.8 0.0 3.2e-07 30.3 0.0 2.3 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF45655.1 - 7.4e-07 29.8 0.0 3.9e-06 27.5 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CCF45655.1 - 0.019 14.5 0.0 0.032 13.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain PrmA PF06325.13 CCF45655.1 - 0.019 14.4 0.0 0.029 13.8 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_4 PF02390.17 CCF45655.1 - 0.17 11.3 0.3 0.66 9.4 0.0 2.0 2 0 0 2 2 2 0 Putative methyltransferase CheR PF01739.18 CCF45655.1 - 0.23 10.9 0.0 0.37 10.2 0.0 1.2 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain FAD_binding_4 PF01565.23 CCF45658.1 - 1.5e-27 96.0 0.8 2.4e-27 95.4 0.8 1.3 1 0 0 1 1 1 1 FAD binding domain Phage_Arf PF17585.2 CCF45658.1 - 0.049 13.6 0.0 0.1 12.6 0.0 1.5 1 0 0 1 1 1 0 Accessory recombination function protein Ribosomal_L3 PF00297.22 CCF45659.1 - 5e-176 585.1 10.2 5.9e-176 584.9 10.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 TCL1_MTCP1 PF01840.17 CCF45661.1 - 0.06 13.0 0.0 0.073 12.7 0.0 1.2 1 0 0 1 1 1 0 TCL1/MTCP1 family PCRF PF03462.18 CCF45662.1 - 1.6e-51 174.9 0.0 2e-51 174.6 0.0 1.1 1 0 0 1 1 1 1 PCRF domain GST_N_3 PF13417.6 CCF45663.1 - 2.7e-16 59.7 0.0 3.2e-16 59.5 0.0 1.0 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 CCF45663.1 - 2.5e-14 53.4 0.0 2.9e-14 53.2 0.0 1.0 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CCF45663.1 - 2.1e-11 43.9 0.0 2.5e-11 43.7 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GluRS_N PF18466.1 CCF45663.1 - 0.03 14.7 0.0 0.04 14.3 0.0 1.2 1 0 0 1 1 1 0 Glutamate--tRNA ligase N-terminal domain Tom37 PF10568.9 CCF45663.1 - 0.06 13.7 0.0 0.098 13.0 0.0 1.3 1 1 0 1 1 1 0 Outer mitochondrial membrane transport complex protein GST_N_4 PF17172.4 CCF45663.1 - 0.12 13.1 0.0 0.32 11.8 0.0 1.7 1 1 0 1 1 1 0 Glutathione S-transferase N-terminal domain DAO PF01266.24 CCF45666.1 - 6.6e-15 55.5 0.1 7.4e-15 55.4 0.1 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase MFS_1 PF07690.16 CCF45667.1 - 6.7e-38 130.5 55.5 6.7e-38 130.5 55.5 2.5 2 1 0 2 2 2 1 Major Facilitator Superfamily Babuvirus_MP PF07234.11 CCF45668.1 - 0.17 12.1 0.7 1.1 9.5 0.2 2.2 2 0 0 2 2 2 0 Movement and RNA silencing protein FAD_binding_4 PF01565.23 CCF45669.1 - 1.2e-19 70.4 4.5 2.2e-19 69.6 3.1 2.0 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.12 CCF45669.1 - 0.059 13.5 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 Berberine and berberine like RNA_pol_Rpb4 PF03874.16 CCF45671.1 - 2.2e-23 82.9 0.0 2.6e-23 82.7 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb4 Polysacc_deac_2 PF04748.13 CCF45671.1 - 0.036 13.2 0.0 0.047 12.9 0.0 1.3 1 0 0 1 1 1 0 Divergent polysaccharide deacetylase Ras PF00071.22 CCF45672.1 - 1.9e-13 50.3 0.0 2.1e-13 50.2 0.0 1.0 1 0 0 1 1 1 1 Ras family Zn_clus PF00172.18 CCF45675.1 - 3.2e-10 40.0 8.4 5.5e-10 39.2 8.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 CCF45675.1 - 0.00091 18.1 0.7 0.0013 17.7 0.7 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Sugar_tr PF00083.24 CCF45677.1 - 3.5e-100 336.0 24.7 4.1e-100 335.8 24.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF45677.1 - 1.4e-30 106.4 20.0 1.4e-30 106.4 20.0 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 CCF45677.1 - 0.00033 19.1 1.3 0.00033 19.1 1.3 2.9 1 1 2 3 3 3 2 Organic Anion Transporter Polypeptide (OATP) family LacY_symp PF01306.19 CCF45677.1 - 0.0011 17.9 0.4 0.0011 17.9 0.4 3.3 3 0 0 3 3 3 2 LacY proton/sugar symporter L51_S25_CI-B8 PF05047.16 CCF45678.1 - 2.2e-16 59.5 0.1 3.6e-16 58.8 0.1 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain U1snRNP70_N PF12220.8 CCF45678.1 - 3 8.6 6.9 3.8 8.2 5.7 1.8 1 1 1 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal MMR_HSR1 PF01926.23 CCF45679.1 - 0.00014 21.9 0.0 0.9 9.6 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase Cortex-I_coil PF09304.10 CCF45679.1 - 0.054 13.7 0.5 0.11 12.7 0.5 1.4 1 0 0 1 1 1 0 Cortexillin I, coiled coil ATPase-cat_bd PF12156.8 CCF45679.1 - 0.19 12.5 0.1 0.5 11.1 0.1 1.7 1 0 0 1 1 1 0 Putative metal-binding domain of cation transport ATPase PPI_Ypi1 PF07491.11 CCF45680.1 - 7.7e-25 86.5 3.9 4.1e-24 84.2 3.9 2.3 1 1 0 1 1 1 1 Protein phosphatase inhibitor CDC45 PF02724.14 CCF45680.1 - 2.3 6.4 8.4 2.4 6.4 8.4 1.2 1 0 0 1 1 1 0 CDC45-like protein cobW PF02492.19 CCF45681.1 - 2.3e-33 115.2 0.0 3e-33 114.9 0.0 1.1 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 CCF45681.1 - 0.00029 19.9 0.6 0.0024 16.9 0.6 2.0 1 1 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_23 PF13476.6 CCF45681.1 - 0.0021 18.6 0.0 0.0028 18.2 0.0 1.2 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 CCF45681.1 - 0.0059 16.7 0.0 0.023 14.8 0.0 2.1 2 1 0 2 2 2 1 50S ribosome-binding GTPase ResIII PF04851.15 CCF45681.1 - 0.078 13.0 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_11 PF13086.6 CCF45681.1 - 0.12 12.1 0.0 14 5.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 CCF45681.1 - 0.13 12.6 0.0 0.18 12.2 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain RIBIOP_C PF04950.12 CCF45682.1 - 1.5e-108 362.7 0.0 2.3e-108 362.1 0.0 1.3 1 0 0 1 1 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 CCF45682.1 - 8.7e-17 61.0 0.0 2.2e-16 59.7 0.0 1.8 1 0 0 1 1 1 1 AARP2CN (NUC121) domain 4HBT PF03061.22 CCF45682.1 - 0.077 13.4 0.0 6.3 7.2 0.0 2.9 3 0 0 3 3 3 0 Thioesterase superfamily AP2 PF00847.20 CCF45682.1 - 0.67 10.2 3.2 3.4 8.0 0.1 3.2 3 0 0 3 3 3 0 AP2 domain CSTF_C PF14304.6 CCF45683.1 - 0.085 12.5 0.1 0.15 11.7 0.1 1.3 1 0 0 1 1 1 0 Transcription termination and cleavage factor C-terminal Pectinesterase PF01095.19 CCF45684.1 - 1.7e-46 158.3 8.3 2.2e-46 158.0 8.3 1.1 1 0 0 1 1 1 1 Pectinesterase DNA_ligase_A_N PF04675.14 CCF45685.1 - 3.4e-40 138.2 0.0 6.3e-40 137.3 0.0 1.5 1 0 0 1 1 1 1 DNA ligase N terminus Mlh1_C PF16413.5 CCF45687.1 - 1.9e-99 332.4 0.0 2.8e-99 331.9 0.0 1.3 1 0 0 1 1 1 1 DNA mismatch repair protein Mlh1 C-terminus DNA_mis_repair PF01119.19 CCF45687.1 - 1.3e-29 102.3 0.0 2.1e-29 101.6 0.0 1.4 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain Thioredoxin_8 PF13905.6 CCF45687.1 - 0.043 14.1 0.0 0.095 13.0 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin-like DAO_C PF16901.5 CCF45687.1 - 0.17 11.7 0.2 0.36 10.7 0.2 1.5 1 0 0 1 1 1 0 C-terminal domain of alpha-glycerophosphate oxidase Gly_radical PF01228.21 CCF45688.1 - 0.03 14.8 0.0 0.049 14.2 0.0 1.2 1 0 0 1 1 1 0 Glycine radical ABC_tran PF00005.27 CCF45692.1 - 1.2e-24 87.4 0.1 1.8e-24 86.8 0.1 1.3 1 0 0 1 1 1 1 ABC transporter DEAD PF00270.29 CCF45692.1 - 0.0012 18.6 0.0 0.0021 17.9 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase SMC_N PF02463.19 CCF45692.1 - 0.0057 16.1 0.0 0.77 9.2 0.0 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain DUF87 PF01935.17 CCF45692.1 - 0.007 16.5 1.1 0.0074 16.4 0.1 1.5 2 0 0 2 2 2 1 Helicase HerA, central domain MMR_HSR1 PF01926.23 CCF45692.1 - 0.012 15.6 0.0 0.03 14.4 0.0 1.7 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_16 PF13191.6 CCF45692.1 - 0.021 15.2 0.0 0.03 14.7 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 CCF45692.1 - 0.03 14.2 0.0 0.05 13.5 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase AAA_29 PF13555.6 CCF45692.1 - 0.035 13.9 0.1 0.088 12.6 0.1 1.7 1 1 0 1 1 1 0 P-loop containing region of AAA domain IstB_IS21 PF01695.17 CCF45692.1 - 0.052 13.3 0.1 0.79 9.4 0.0 2.1 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_30 PF13604.6 CCF45692.1 - 0.078 12.7 0.1 0.21 11.3 0.1 1.7 1 1 0 1 1 1 0 AAA domain SbcCD_C PF13558.6 CCF45692.1 - 0.097 12.9 0.0 0.18 12.0 0.0 1.5 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_21 PF13304.6 CCF45692.1 - 0.13 12.0 0.5 2.5 7.8 0.1 2.4 3 0 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_7 PF12775.7 CCF45692.1 - 0.2 11.1 0.1 0.32 10.5 0.1 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region Hydrolase_4 PF12146.8 CCF45693.1 - 0.0031 16.8 0.0 0.005 16.1 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CCF45693.1 - 0.0063 17.1 0.2 0.02 15.5 0.2 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family LCAT PF02450.15 CCF45693.1 - 0.059 12.5 0.0 0.14 11.3 0.0 1.6 2 0 0 2 2 2 0 Lecithin:cholesterol acyltransferase Abhydrolase_1 PF00561.20 CCF45693.1 - 0.14 11.8 0.0 0.43 10.2 0.0 1.7 2 0 0 2 2 2 0 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CCF45693.1 - 0.2 11.1 0.0 0.34 10.4 0.0 1.2 1 0 0 1 1 1 0 Prolyl oligopeptidase family DUF676 PF05057.14 CCF45693.1 - 0.22 11.0 0.0 0.54 9.7 0.0 1.6 2 0 0 2 2 2 0 Putative serine esterase (DUF676) Palm_thioest PF02089.15 CCF45693.1 - 0.22 11.3 0.0 0.36 10.6 0.0 1.3 1 0 0 1 1 1 0 Palmitoyl protein thioesterase RNA_pol_Rpc82 PF05645.13 CCF45694.1 - 3.3e-42 145.0 0.0 5.2e-42 144.4 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase III subunit RPC82 HsbA PF12296.8 CCF45696.1 - 4.6e-27 94.8 17.4 4.6e-27 94.8 17.4 1.8 2 0 0 2 2 2 1 Hydrophobic surface binding protein A Podoplanin PF05808.11 CCF45696.1 - 0.0056 16.8 2.3 0.0084 16.2 2.3 1.3 1 0 0 1 1 1 1 Podoplanin T3SS_TC PF06511.11 CCF45696.1 - 0.01 15.2 6.8 0.014 14.8 6.8 1.2 1 0 0 1 1 1 0 Type III secretion systems tip complex components NPV_P10 PF05531.12 CCF45696.1 - 0.49 10.9 12.2 1.3 9.5 0.3 3.1 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein I_LWEQ PF01608.17 CCF45696.1 - 1.2 9.4 8.7 3.2 8.0 7.1 2.0 1 1 1 2 2 2 0 I/LWEQ domain Ribosomal_60s PF00428.19 CCF45696.1 - 2 9.1 13.9 0.25 11.9 7.2 2.4 2 1 0 2 2 2 0 60s Acidic ribosomal protein Ctr PF04145.15 CCF45697.1 - 2.8e-29 102.6 11.9 2.8e-27 96.2 11.9 2.0 1 1 0 1 1 1 1 Ctr copper transporter family Sperm_Ag_HE2 PF05324.13 CCF45697.1 - 0.067 13.7 0.1 0.11 12.9 0.1 1.3 1 0 0 1 1 1 0 Sperm antigen HE2 EpuA PF11772.8 CCF45697.1 - 0.74 9.5 7.4 0.49 10.1 0.2 2.4 2 0 0 2 2 2 0 DNA-directed RNA polymerase subunit beta Ribosomal_L4 PF00573.22 CCF45698.1 - 2.2e-13 50.3 0.0 2.7e-13 50.0 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family DUF3604 PF12228.8 CCF45698.1 - 0.046 12.2 0.0 0.058 11.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3604) p450 PF00067.22 CCF45701.1 - 6.1e-41 140.6 0.0 6.8e-41 140.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Aldo_ket_red PF00248.21 CCF45702.1 - 1e-42 146.4 0.0 3.2e-42 144.7 0.0 1.7 1 1 0 1 1 1 1 Aldo/keto reductase family AA_permease_2 PF13520.6 CCF45703.1 - 8.7e-54 183.0 33.2 1.1e-53 182.6 33.2 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CCF45703.1 - 1.4e-21 76.7 32.1 5.5e-21 74.7 23.7 2.2 2 0 0 2 2 2 2 Amino acid permease Sacchrp_dh_C PF16653.5 CCF45704.1 - 4.5e-94 315.5 0.0 6.6e-94 314.9 0.0 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase C-terminal domain Sacchrp_dh_NADP PF03435.18 CCF45704.1 - 1.1e-25 90.3 0.2 1.8e-25 89.7 0.2 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 CCF45704.1 - 2.1e-05 24.6 0.0 3.7e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_10 PF13460.6 CCF45704.1 - 0.00014 21.8 0.2 0.00024 21.0 0.2 1.4 1 0 0 1 1 1 1 NAD(P)H-binding IlvN PF07991.12 CCF45704.1 - 0.0023 17.5 0.2 0.023 14.3 0.0 2.6 2 1 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain GFO_IDH_MocA PF01408.22 CCF45704.1 - 0.044 14.6 0.0 0.14 12.9 0.0 1.8 2 0 0 2 2 2 0 Oxidoreductase family, NAD-binding Rossmann fold GATA PF00320.27 CCF45705.1 - 6.5e-10 38.5 7.8 6.5e-10 38.5 7.8 2.0 2 0 0 2 2 2 1 GATA zinc finger DUF4746 PF15928.5 CCF45706.1 - 0.0051 16.3 1.9 0.0058 16.1 1.9 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4746) DDHD PF02862.17 CCF45706.1 - 0.0051 17.0 6.5 0.0066 16.6 6.5 1.2 1 0 0 1 1 1 1 DDHD domain Sec62 PF03839.16 CCF45706.1 - 0.02 14.4 10.3 0.028 13.9 10.3 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 FAM76 PF16046.5 CCF45706.1 - 0.031 13.6 11.9 0.039 13.3 11.9 1.2 1 0 0 1 1 1 0 FAM76 protein Exonuc_VII_L PF02601.15 CCF45706.1 - 0.033 13.8 10.5 0.037 13.6 10.5 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit RP-C_C PF11800.8 CCF45706.1 - 0.042 13.9 10.9 0.063 13.4 10.9 1.3 1 0 0 1 1 1 0 Replication protein C C-terminal region DUF4638 PF15472.6 CCF45706.1 - 0.071 12.8 11.0 0.12 12.1 11.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) Endostatin PF06482.11 CCF45706.1 - 0.15 11.5 20.1 0.19 11.2 20.1 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin PAT1 PF09770.9 CCF45706.1 - 0.15 10.3 42.0 0.18 10.0 42.0 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SID-1_RNA_chan PF13965.6 CCF45706.1 - 0.24 9.8 0.5 0.26 9.7 0.5 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 CobT PF06213.12 CCF45706.1 - 0.41 10.0 16.4 0.74 9.2 16.4 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CPSF100_C PF13299.6 CCF45706.1 - 0.42 10.8 7.7 0.67 10.1 7.7 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal EMC3_TMCO1 PF01956.16 CCF45706.1 - 0.48 10.1 7.6 0.89 9.3 7.6 1.5 1 1 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Presenilin PF01080.17 CCF45706.1 - 0.58 8.9 16.7 0.76 8.5 16.7 1.3 1 0 0 1 1 1 0 Presenilin ALMT PF11744.8 CCF45706.1 - 0.65 8.8 11.5 0.9 8.3 11.5 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter SLC12 PF03522.15 CCF45706.1 - 0.78 8.7 13.4 0.98 8.4 13.4 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Peroxin-13_N PF04088.13 CCF45706.1 - 0.91 9.8 6.3 2.1 8.6 6.3 1.7 1 0 0 1 1 1 0 Peroxin 13, N-terminal region MDM10 PF12519.8 CCF45706.1 - 1 8.2 10.7 1.4 7.7 10.7 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 FAM60A PF15396.6 CCF45706.1 - 1.1 9.2 8.5 1.4 8.9 8.5 1.2 1 0 0 1 1 1 0 Protein Family FAM60A EOS1 PF12326.8 CCF45706.1 - 1.1 9.1 10.9 1.9 8.4 10.9 1.3 1 0 0 1 1 1 0 N-glycosylation protein Otopetrin PF03189.13 CCF45706.1 - 1.2 7.8 6.8 1.8 7.3 6.8 1.3 1 0 0 1 1 1 0 Otopetrin PP_kinase_N PF13089.6 CCF45706.1 - 2.4 8.5 10.8 4.8 7.5 10.8 1.6 1 0 0 1 1 1 0 Polyphosphate kinase N-terminal domain DUF4407 PF14362.6 CCF45706.1 - 2.5 7.4 9.8 3.4 7.0 9.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Paramyxo_ncap PF00973.19 CCF45706.1 - 2.6 6.9 6.9 2.9 6.7 6.9 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein RR_TM4-6 PF06459.12 CCF45706.1 - 2.9 7.6 13.4 4.5 7.0 13.4 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF3381 PF11861.8 CCF45706.1 - 3.5 7.4 17.2 6.7 6.5 17.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) Plasmodium_Vir PF05795.11 CCF45706.1 - 3.6 6.9 5.9 4.1 6.7 5.9 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein CBP_BcsG PF11658.8 CCF45706.1 - 4.9 5.4 12.9 7.4 4.8 12.9 1.2 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG GREB1 PF15782.5 CCF45706.1 - 9.1 3.2 18.6 10 3.1 18.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Serinc PF03348.15 CCF45706.1 - 9.8 5.0 7.4 13 4.6 7.4 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Oxysterol_BP PF01237.18 CCF45708.1 - 2.8e-61 207.4 0.8 6.9e-54 183.1 0.0 2.0 1 1 1 2 2 2 2 Oxysterol-binding protein ILVD_EDD PF00920.21 CCF45709.1 - 1.9e-11 43.3 0.0 2.2e-11 43.1 0.0 1.0 1 0 0 1 1 1 1 Dehydratase family ILVD_EDD PF00920.21 CCF45710.1 - 4e-43 147.8 0.0 4.3e-43 147.7 0.0 1.0 1 0 0 1 1 1 1 Dehydratase family Herpes_U44 PF04533.13 CCF45710.1 - 0.03 14.0 0.0 0.035 13.7 0.0 1.0 1 0 0 1 1 1 0 Herpes virus U44 protein TPK_catalytic PF04263.16 CCF45711.1 - 5.7e-28 97.4 0.0 7.8e-28 96.9 0.0 1.1 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.14 CCF45711.1 - 9.5e-23 79.7 1.2 1.4e-22 79.2 0.5 1.6 2 0 0 2 2 2 1 Thiamin pyrophosphokinase, vitamin B1 binding domain V-SNARE_C PF12352.8 CCF45712.1 - 2.1e-15 56.7 0.2 2.4e-15 56.5 0.2 1.1 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 CCF45712.1 - 0.00016 21.5 0.0 0.00018 21.3 0.0 1.1 1 0 0 1 1 1 1 Sec20 Sigma70_r4 PF04545.16 CCF45712.1 - 0.0046 16.4 0.0 0.007 15.9 0.0 1.3 1 0 0 1 1 1 1 Sigma-70, region 4 E2F_TDP PF02319.20 CCF45712.1 - 0.052 13.6 0.0 0.067 13.3 0.0 1.2 1 0 0 1 1 1 0 E2F/DP family winged-helix DNA-binding domain Zn_clus PF00172.18 CCF45713.1 - 0.051 13.7 14.8 0.079 13.1 14.8 1.3 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Cnd1_N PF12922.7 CCF45716.1 - 1.2e-62 210.7 0.1 2e-62 209.9 0.1 1.4 1 0 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1, N-term Ald_Xan_dh_C2 PF02738.18 CCF45716.1 - 0.031 12.7 0.0 0.047 12.2 0.0 1.2 1 0 0 1 1 1 0 Molybdopterin-binding domain of aldehyde dehydrogenase MIEAP PF16026.5 CCF45716.1 - 0.13 12.5 0.1 0.21 11.8 0.1 1.4 1 0 0 1 1 1 0 Mitochondria-eating protein Peptidase_C48 PF02902.19 CCF45719.1 - 2.2e-07 30.9 0.0 9.5e-07 28.9 0.0 1.9 2 0 0 2 2 2 1 Ulp1 protease family, C-terminal catalytic domain zf-B_box PF00643.24 CCF45720.1 - 6.2e-05 23.1 3.2 0.00011 22.3 3.2 1.3 1 0 0 1 1 1 1 B-box zinc finger ZZ PF00569.17 CCF45720.1 - 3.7 7.4 7.6 6.9 6.6 7.6 1.5 1 0 0 1 1 1 0 Zinc finger, ZZ type C1_2 PF03107.16 CCF45720.1 - 4.6 7.6 8.5 8.7 6.7 8.5 1.4 1 0 0 1 1 1 0 C1 domain ketoacyl-synt PF00109.26 CCF45721.1 - 1.9e-72 243.9 0.0 2.3e-72 243.6 0.0 1.0 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Thiolase_N PF00108.23 CCF45721.1 - 3.2e-06 26.7 0.1 1e-05 25.0 0.1 1.7 2 0 0 2 2 2 1 Thiolase, N-terminal domain Serglycin PF04360.12 CCF45722.1 - 0.013 15.5 0.4 0.026 14.5 0.4 1.5 1 0 0 1 1 1 0 Serglycin AAA_16 PF13191.6 CCF45723.1 - 1.1e-09 39.0 0.1 3.7e-09 37.2 0.0 2.0 1 1 1 2 2 2 1 AAA ATPase domain ATPase_2 PF01637.18 CCF45723.1 - 4.3e-05 23.5 0.2 7e-05 22.9 0.2 1.3 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_7 PF12775.7 CCF45723.1 - 0.053 13.0 0.0 0.16 11.5 0.0 1.7 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_25 PF13481.6 CCF45723.1 - 0.061 12.9 0.7 4.1 6.9 0.0 2.8 3 0 0 3 3 3 0 AAA domain DUF815 PF05673.13 CCF45723.1 - 0.061 12.5 0.0 0.12 11.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) BNR PF02012.20 CCF45724.1 - 0.029 14.3 5.7 0.08 13.0 0.5 3.1 3 0 0 3 3 3 0 BNR/Asp-box repeat Arif-1 PF06770.11 CCF45724.1 - 0.12 12.0 0.2 0.17 11.5 0.2 1.2 1 0 0 1 1 1 0 Actin-rearrangement-inducing factor (Arif-1) FXa_inhibition PF14670.6 CCF45726.1 - 0.2 11.9 6.4 0.17 12.2 4.5 1.9 2 0 0 2 2 2 0 Coagulation Factor Xa inhibitory site DUF3433 PF11915.8 CCF45728.1 - 1e-15 57.9 5.7 1e-15 57.9 5.7 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF3433) MFS_1 PF07690.16 CCF45729.1 - 1.3e-44 152.6 33.0 3e-44 151.4 33.0 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF45729.1 - 9.4e-12 44.5 14.6 1.2e-11 44.2 12.1 2.0 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_4 PF06779.14 CCF45729.1 - 0.0014 18.0 7.6 0.0028 17.0 7.6 1.5 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB OATP PF03137.20 CCF45729.1 - 0.0092 14.3 12.8 0.0045 15.4 7.6 2.5 1 1 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family CorA PF01544.18 CCF45730.1 - 3.7e-06 26.5 11.4 7.6e-06 25.5 8.4 2.5 2 1 0 2 2 2 1 CorA-like Mg2+ transporter protein FlxA PF14282.6 CCF45730.1 - 0.015 15.2 1.4 0.065 13.2 0.8 2.1 2 0 0 2 2 2 0 FlxA-like protein Baculo_PEP_C PF04513.12 CCF45730.1 - 0.039 14.0 0.3 0.12 12.5 0.2 1.6 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Seryl_tRNA_N PF02403.22 CCF45730.1 - 0.047 13.9 1.1 0.13 12.5 0.4 2.0 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain KxDL PF10241.9 CCF45730.1 - 3.4 8.0 5.4 2.1 8.7 0.9 2.6 3 0 0 3 3 3 0 Uncharacterized conserved protein LMBR1 PF04791.16 CCF45730.1 - 6.1 5.6 8.0 2.2 7.1 0.6 2.8 2 1 1 3 3 3 0 LMBR1-like membrane protein Pkinase PF00069.25 CCF45733.1 - 1.4e-14 54.1 0.0 5.5e-14 52.2 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF45733.1 - 2.7e-09 36.7 0.0 1.1e-08 34.7 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase MMR_HSR1_C PF08438.10 CCF45734.1 - 8.7e-37 126.1 0.0 1.5e-36 125.3 0.0 1.4 1 0 0 1 1 1 1 GTPase of unknown function C-terminal MMR_HSR1 PF01926.23 CCF45734.1 - 8.9e-08 32.2 0.0 2.3e-07 30.9 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CCF45734.1 - 0.086 12.7 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase MMR_HSR1_Xtn PF16897.5 CCF45734.1 - 0.15 12.1 0.2 0.27 11.2 0.2 1.4 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain adh_short PF00106.25 CCF45735.1 - 2.3e-07 30.5 0.0 3.1e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF45735.1 - 1.5e-06 28.0 0.0 1.9e-06 27.6 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase RmlD_sub_bind PF04321.17 CCF45735.1 - 0.002 17.3 0.0 0.0034 16.5 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.21 CCF45735.1 - 0.04 13.4 0.0 0.061 12.8 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family 3HCDH_N PF02737.18 CCF45735.1 - 0.078 12.9 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain IFRD PF05004.13 CCF45737.1 - 1.2e-69 234.8 3.3 1.7e-69 234.3 3.3 1.2 1 0 0 1 1 1 1 Interferon-related developmental regulator (IFRD) HEAT_EZ PF13513.6 CCF45737.1 - 4.5e-06 27.0 0.0 0.0041 17.6 0.0 3.5 2 1 1 3 3 3 2 HEAT-like repeat HEAT_2 PF13646.6 CCF45737.1 - 0.0036 17.6 0.1 0.13 12.6 0.0 2.7 1 1 0 2 2 2 1 HEAT repeats HEAT PF02985.22 CCF45737.1 - 0.018 15.3 0.1 1.4 9.4 0.0 3.4 4 0 0 4 4 4 0 HEAT repeat FHA PF00498.26 CCF45738.1 - 1.1e-13 51.3 0.2 2e-13 50.4 0.2 1.5 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 CCF45738.1 - 0.012 15.9 0.0 0.027 14.8 0.0 1.5 1 0 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain WD40 PF00400.32 CCF45739.1 - 1.9e-40 136.1 16.8 5.5e-10 39.7 0.0 8.0 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF45739.1 - 1.5e-14 54.1 0.9 0.012 15.9 0.0 4.9 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CCF45739.1 - 2.2e-08 33.4 0.4 0.2 10.6 0.0 4.7 1 1 2 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 CCF45739.1 - 5.5e-07 28.6 3.4 0.081 11.6 0.1 4.7 3 1 0 4 4 4 3 Nucleoporin Nup120/160 PALB2_WD40 PF16756.5 CCF45739.1 - 4.1e-05 22.7 4.4 5.4e-05 22.3 0.1 3.0 3 1 1 4 4 4 1 Partner and localizer of BRCA2 WD40 domain Frtz PF11768.8 CCF45739.1 - 0.00021 19.7 0.0 0.0011 17.3 0.0 2.1 2 1 1 3 3 3 1 WD repeat-containing and planar cell polarity effector protein Fritz HPS3_N PF14761.6 CCF45739.1 - 0.0012 18.4 0.0 0.024 14.2 0.0 2.5 2 1 1 3 3 3 1 Hermansky-Pudlak syndrome 3 Coatomer_WDAD PF04053.14 CCF45739.1 - 0.0014 17.8 0.0 0.0019 17.4 0.0 1.2 1 0 0 1 1 1 1 Coatomer WD associated region DUF1513 PF07433.11 CCF45739.1 - 0.0072 15.4 0.8 2.3 7.2 0.0 3.3 1 1 1 3 3 3 2 Protein of unknown function (DUF1513) Nucleoporin_N PF08801.11 CCF45739.1 - 0.092 11.5 0.3 2.5 6.8 0.0 2.9 3 1 0 3 3 3 0 Nup133 N terminal like Hira PF07569.11 CCF45739.1 - 0.12 12.1 0.9 13 5.4 0.4 3.1 1 1 1 2 2 2 0 TUP1-like enhancer of split Pkinase PF00069.25 CCF45740.1 - 9.6e-11 41.5 0.0 1.7e-10 40.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain HEAT PF02985.22 CCF45740.1 - 3.1e-09 36.3 3.6 0.1 12.9 0.0 5.7 5 1 1 6 6 6 3 HEAT repeat Cnd1 PF12717.7 CCF45740.1 - 7.1e-06 26.2 0.0 2e-05 24.7 0.0 1.8 1 1 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 Pkinase_Tyr PF07714.17 CCF45740.1 - 4.8e-05 22.8 0.0 9.2e-05 21.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase HEAT_2 PF13646.6 CCF45740.1 - 6.6e-05 23.2 0.0 0.023 15.1 0.0 3.7 2 1 2 4 4 4 2 HEAT repeats HEAT_EZ PF13513.6 CCF45740.1 - 0.0013 19.2 0.1 6.8 7.3 0.0 3.8 3 1 1 4 4 4 2 HEAT-like repeat Vac14_Fab1_bd PF12755.7 CCF45740.1 - 0.14 12.8 0.1 2.8 8.6 0.0 2.7 2 1 1 3 3 3 0 Vacuolar 14 Fab1-binding region Adaptin_N PF01602.20 CCF45740.1 - 0.17 10.4 0.1 1.1 7.7 0.1 1.8 1 1 1 2 2 2 0 Adaptin N terminal region Peptidase_S8 PF00082.22 CCF45741.1 - 3.8e-17 62.5 0.0 5.3e-17 62.0 0.0 1.2 1 0 0 1 1 1 1 Subtilase family UEV PF05743.13 CCF45742.1 - 6.6e-37 126.1 0.0 1e-36 125.4 0.0 1.3 1 0 0 1 1 1 1 UEV domain UQ_con PF00179.26 CCF45742.1 - 0.003 17.2 0.1 0.0045 16.6 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RSN1_TM PF13967.6 CCF45744.1 - 9.7e-31 106.6 1.1 1.2e-30 106.4 1.1 1.0 1 0 0 1 1 1 1 Late exocytosis, associated with Golgi transport Transp_cyt_pur PF02133.15 CCF45745.1 - 9.1e-43 146.6 36.2 1.1e-42 146.3 36.2 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin NTP_transf_6 PF06042.11 CCF45746.1 - 1.8e-38 131.9 0.0 5.1e-19 68.7 0.0 2.1 1 1 1 2 2 2 2 Nucleotidyltransferase AP_endonuc_2 PF01261.24 CCF45747.1 - 2.3e-39 135.0 0.0 3.1e-39 134.6 0.0 1.2 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel 2OG-FeII_Oxy_3 PF13640.6 CCF45748.1 - 1.6e-08 35.4 0.0 3.4e-08 34.3 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Ribosomal_L6 PF00347.23 CCF45749.1 - 1.8e-24 86.2 6.2 1.3e-11 45.0 0.1 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 RCR PF12273.8 CCF45750.1 - 3.6e-15 56.6 9.5 8.1e-15 55.5 9.4 1.6 1 1 0 1 1 1 1 Chitin synthesis regulation, resistance to Congo red Adeno_E3_CR2 PF02439.15 CCF45750.1 - 0.012 15.3 0.7 0.027 14.2 0.7 1.6 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 CYYR1 PF10873.8 CCF45750.1 - 0.047 14.1 0.3 0.089 13.2 0.3 1.4 1 1 0 1 1 1 0 Cysteine and tyrosine-rich protein 1 DUF4381 PF14316.6 CCF45750.1 - 0.12 12.6 1.5 0.19 12.0 1.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Herpes_gE PF02480.16 CCF45750.1 - 0.17 10.6 0.0 0.19 10.5 0.0 1.1 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E Glyco_hydro_31 PF01055.26 CCF45751.1 - 2.5e-101 340.0 8.1 1.3e-100 337.7 8.1 1.9 1 1 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 CCF45751.1 - 2.5e-08 34.1 0.8 7.9e-08 32.5 0.8 2.0 1 0 0 1 1 1 1 Galactose mutarotase-like DUF5110 PF17137.4 CCF45751.1 - 0.00035 20.8 0.5 0.0055 16.9 0.0 2.9 3 0 0 3 3 3 1 Domain of unknown function (DUF5110) Aa_trans PF01490.18 CCF45752.1 - 1.2e-41 142.8 35.1 1.4e-41 142.6 35.1 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein ATG27 PF09451.10 CCF45752.1 - 0.14 11.9 0.9 0.24 11.2 0.9 1.3 1 0 0 1 1 1 0 Autophagy-related protein 27 Bac_luciferase PF00296.20 CCF45753.1 - 8.9e-21 74.6 0.1 9.6e-21 74.5 0.1 1.0 1 0 0 1 1 1 1 Luciferase-like monooxygenase Bac_luciferase PF00296.20 CCF45754.1 - 0.047 13.1 0.0 0.052 13.0 0.0 1.1 1 0 0 1 1 1 0 Luciferase-like monooxygenase Oxidored_molyb PF00174.19 CCF45755.1 - 5.7e-45 153.0 0.0 1.4e-44 151.7 0.0 1.6 2 0 0 2 2 2 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.16 CCF45755.1 - 2.4e-20 72.9 2.5 4.8e-20 72.0 2.5 1.4 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain Glyco_hydro_127 PF07944.12 CCF45755.1 - 0.14 10.6 0.0 0.2 10.1 0.0 1.1 1 0 0 1 1 1 0 Beta-L-arabinofuranosidase, GH127 Acyl_transf_1 PF00698.21 CCF45756.1 - 1.3e-15 57.7 0.0 8.7e-11 41.9 0.0 2.2 2 0 0 2 2 2 2 Acyl transferase domain DUF2458 PF10454.9 CCF45756.1 - 0.035 13.8 0.0 0.054 13.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2458) DUF5421 PF17458.2 CCF45758.1 - 0.22 10.9 0.0 0.23 10.8 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5421) CLU PF13236.6 CCF45763.1 - 3.4e-77 259.2 0.0 5.9e-77 258.4 0.0 1.4 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.7 CCF45763.1 - 4.1e-53 180.0 0.7 7.6e-53 179.1 0.0 1.9 2 0 0 2 2 2 1 Translation initiation factor eIF3 subunit 135 TPR_12 PF13424.6 CCF45763.1 - 1.4e-24 86.2 11.1 2.1e-10 40.7 0.1 4.3 3 1 1 4 4 4 3 Tetratricopeptide repeat CLU_N PF15044.6 CCF45763.1 - 5.9e-24 84.2 0.1 1.7e-23 82.7 0.1 1.9 1 0 0 1 1 1 1 Mitochondrial function, CLU-N-term TPR_10 PF13374.6 CCF45763.1 - 3.9e-22 77.4 2.7 1.2e-05 25.0 0.1 5.5 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 CCF45763.1 - 6e-05 22.9 2.8 0.0062 16.6 0.2 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 CCF45763.1 - 9.6e-05 22.2 3.6 0.03 14.4 0.1 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat DDHD PF02862.17 CCF45763.1 - 0.0013 19.0 0.4 0.0027 17.9 0.4 1.6 1 0 0 1 1 1 1 DDHD domain K_channel_TID PF07941.11 CCF45763.1 - 0.16 12.4 0.7 0.41 11.1 0.7 1.6 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain CDC45 PF02724.14 CCF45763.1 - 0.24 9.7 14.1 0.38 9.0 14.1 1.2 1 0 0 1 1 1 0 CDC45-like protein AF-4 PF05110.13 CCF45763.1 - 0.24 9.4 16.9 0.38 8.8 16.9 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Forkhead PF00250.18 CCF45764.1 - 9e-35 118.8 0.5 2.2e-34 117.5 0.5 1.7 2 0 0 2 2 2 1 Forkhead domain FHA PF00498.26 CCF45764.1 - 1.1e-09 38.5 0.0 2.5e-09 37.3 0.0 1.7 1 0 0 1 1 1 1 FHA domain Linker_histone PF00538.19 CCF45764.1 - 0.43 11.0 1.3 0.68 10.3 0.1 2.0 2 0 0 2 2 2 0 linker histone H1 and H5 family BOP1NT PF08145.12 CCF45765.1 - 1.3e-47 162.9 11.3 2.1e-47 162.3 11.3 1.3 1 0 0 1 1 1 1 BOP1NT (NUC169) domain WD40 PF00400.32 CCF45765.1 - 1.6e-23 82.5 4.3 1.5e-10 41.5 0.2 5.6 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF45765.1 - 3.8e-07 30.3 0.1 0.002 18.4 0.0 4.5 4 2 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain Anticodon_1 PF08264.13 CCF45767.1 - 1.6e-26 93.1 0.0 8.6e-26 90.7 0.0 2.1 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA Amidohydro_3 PF07969.11 CCF45771.1 - 1.3e-33 117.2 0.1 1.6e-33 116.9 0.1 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_1 PF01979.20 CCF45771.1 - 0.00025 20.5 0.1 0.0086 15.4 0.0 2.1 2 0 0 2 2 2 2 Amidohydrolase family Glyco_hydro_7 PF00840.20 CCF45772.1 - 3.3e-172 573.1 22.1 3.7e-172 572.9 22.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 7 Colipase-like PF15083.6 CCF45772.1 - 0.1 12.8 0.1 0.27 11.4 0.1 1.7 1 0 0 1 1 1 0 Colipase-like Bromodomain PF00439.25 CCF45773.1 - 4.1e-16 58.8 0.0 9.8e-16 57.6 0.0 1.6 1 0 0 1 1 1 1 Bromodomain CHCH PF06747.13 CCF45773.1 - 0.031 14.4 1.5 1.6 8.9 0.0 2.4 2 0 0 2 2 2 0 CHCH domain Aa_trans PF01490.18 CCF45776.1 - 6e-15 54.9 0.8 6.1e-15 54.8 0.8 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein DUF1056 PF06341.11 CCF45776.1 - 0.057 13.7 0.3 0.13 12.6 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1056) Phage_CII PF05269.11 CCF45776.1 - 0.15 12.3 0.0 0.27 11.4 0.0 1.3 1 0 0 1 1 1 0 Bacteriophage CII protein RNA_pol_L_2 PF13656.6 CCF45777.1 - 2.4e-24 84.9 0.2 2.9e-24 84.6 0.2 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 CCF45777.1 - 1.3e-07 30.9 0.1 6.9e-07 28.6 0.1 2.0 1 1 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Cep57_MT_bd PF06657.13 CCF45777.1 - 0.039 14.4 0.2 0.094 13.2 0.1 1.7 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 SseB_C PF14581.6 CCF45777.1 - 0.062 13.4 0.0 0.081 13.0 0.0 1.2 1 0 0 1 1 1 0 SseB protein C-terminal domain LSM PF01423.22 CCF45778.1 - 3.2e-22 78.0 0.1 3.5e-22 77.9 0.1 1.0 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 CCF45778.1 - 0.025 14.7 0.0 0.029 14.5 0.0 1.1 1 0 0 1 1 1 0 Ataxin 2 SM domain DNA_pol_A_exo1 PF01612.20 CCF45779.1 - 2.2e-17 63.3 0.0 3.1e-17 62.9 0.0 1.2 1 0 0 1 1 1 1 3'-5' exonuclease NAD_binding_2 PF03446.15 CCF45780.1 - 6.8e-05 23.1 0.0 8.3e-05 22.8 0.0 1.1 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 CCF45780.1 - 0.00092 19.7 0.1 0.0013 19.3 0.1 1.2 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.18 CCF45780.1 - 0.0066 16.3 0.1 0.0097 15.8 0.1 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Sulfate_transp PF00916.20 CCF45781.1 - 3.6e-48 164.2 4.2 4.3e-48 164.0 4.2 1.1 1 0 0 1 1 1 1 Sulfate permease family MFS_MOT1 PF16983.5 CCF45781.1 - 0.098 13.1 3.3 0.28 11.6 3.3 1.8 1 1 0 1 1 1 0 Molybdate transporter of MFS superfamily Phage_holin_2_3 PF16080.5 CCF45781.1 - 0.87 9.4 0.0 0.87 9.4 0.0 2.6 3 0 0 3 3 3 0 Bacteriophage holin family HP1 Methyltransf_23 PF13489.6 CCF45782.1 - 3.5e-14 53.0 0.0 5e-14 52.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF45782.1 - 2.7e-05 24.0 0.0 0.00017 21.4 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF45782.1 - 0.00017 22.2 0.0 0.00034 21.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF45782.1 - 0.00046 20.9 0.0 0.0026 18.4 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain CheR PF01739.18 CCF45782.1 - 0.00055 19.5 0.0 0.00091 18.8 0.0 1.3 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain Methyltransf_11 PF08241.12 CCF45782.1 - 0.0011 19.6 0.0 0.0028 18.2 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain DDE_1 PF03184.19 CCF45783.1 - 7.2e-12 45.3 0.0 1.1e-11 44.8 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_psq PF05225.16 CCF45783.1 - 1.8e-08 34.0 0.0 3.6e-08 33.0 0.0 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.16 CCF45783.1 - 9.7e-07 28.7 0.1 3.8e-06 26.8 0.0 2.1 1 1 1 2 2 2 1 Tc5 transposase DNA-binding domain DDE_1 PF03184.19 CCF45784.1 - 2.9e-21 75.9 0.0 4.1e-21 75.4 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_psq PF05225.16 CCF45784.1 - 5.6e-09 35.6 0.0 1.2e-08 34.5 0.0 1.6 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.16 CCF45784.1 - 0.00014 21.8 0.0 0.00035 20.5 0.0 1.7 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DDE_3 PF13358.6 CCF45784.1 - 0.0055 16.5 0.1 0.064 13.0 0.1 2.1 2 0 0 2 2 2 1 DDE superfamily endonuclease SecM PF06558.12 CCF45787.1 - 0.082 13.0 0.0 0.089 12.9 0.0 1.1 1 0 0 1 1 1 0 Secretion monitor precursor protein (SecM) NUC202 PF08166.12 CCF45787.1 - 0.087 12.9 0.1 0.097 12.8 0.1 1.2 1 0 0 1 1 1 0 NUC202 domain CVNH PF08881.10 CCF45789.1 - 4.6e-16 59.3 0.9 6.7e-16 58.8 0.9 1.2 1 0 0 1 1 1 1 CVNH domain PAS_9 PF13426.7 CCF45790.1 - 1.3e-14 54.3 0.0 2.2e-13 50.3 0.0 2.4 2 0 0 2 2 2 1 PAS domain RGS PF00615.19 CCF45790.1 - 8.1e-09 35.8 0.3 2.2e-08 34.4 0.3 1.6 1 0 0 1 1 1 1 Regulator of G protein signaling domain PAS_3 PF08447.12 CCF45790.1 - 0.021 15.1 0.0 0.071 13.4 0.0 2.0 1 0 0 1 1 1 0 PAS fold PAS PF00989.25 CCF45790.1 - 0.036 14.1 0.0 0.1 12.6 0.0 1.7 1 0 0 1 1 1 0 PAS fold Glyco_hydro_61 PF03443.14 CCF45791.1 - 0.00046 20.2 0.1 0.0018 18.2 0.0 1.8 1 1 1 2 2 2 1 Glycosyl hydrolase family 61 ATP-synt_ab PF00006.25 CCF45791.1 - 0.086 12.5 0.1 0.13 11.9 0.1 1.3 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain CDC45 PF02724.14 CCF45794.1 - 0.00074 17.9 13.3 0.00075 17.9 13.3 1.1 1 0 0 1 1 1 1 CDC45-like protein Nop14 PF04147.12 CCF45794.1 - 0.002 16.4 26.1 0.0025 16.1 26.1 1.0 1 0 0 1 1 1 1 Nop14-like family SDA1 PF05285.12 CCF45794.1 - 0.015 14.7 21.5 0.019 14.4 21.5 1.2 1 0 0 1 1 1 0 SDA1 Presenilin PF01080.17 CCF45794.1 - 0.02 13.7 3.9 0.022 13.5 3.9 1.1 1 0 0 1 1 1 0 Presenilin SAPS PF04499.15 CCF45794.1 - 0.065 12.0 10.4 0.083 11.7 10.4 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein CPSF100_C PF13299.6 CCF45794.1 - 0.13 12.4 6.6 0.23 11.6 6.6 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF5523 PF17661.1 CCF45794.1 - 0.41 10.3 12.7 0.63 9.7 12.7 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5523) eIF-3c_N PF05470.12 CCF45794.1 - 0.46 8.7 10.6 0.56 8.5 10.6 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Zip PF02535.22 CCF45794.1 - 0.76 8.9 5.6 0.77 8.9 5.6 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Mpp10 PF04006.12 CCF45794.1 - 1.2 7.5 26.7 1.5 7.2 26.7 1.1 1 0 0 1 1 1 0 Mpp10 protein BUD22 PF09073.10 CCF45794.1 - 1.9 7.8 24.3 2.4 7.4 24.3 1.1 1 0 0 1 1 1 0 BUD22 Tim54 PF11711.8 CCF45794.1 - 2.1 7.0 7.6 2.8 6.6 7.6 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Sporozoite_P67 PF05642.11 CCF45794.1 - 3.2 5.7 18.3 6 4.8 18.2 1.4 2 0 0 2 2 2 0 Sporozoite P67 surface antigen PDCD2_C PF04194.13 CCF45794.1 - 3.3 7.8 10.2 5 7.2 10.2 1.3 1 0 0 1 1 1 0 Programmed cell death protein 2, C-terminal putative domain LAP1C PF05609.12 CCF45794.1 - 4 6.4 12.8 5.3 6.0 12.8 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) RR_TM4-6 PF06459.12 CCF45794.1 - 5 6.9 10.1 7.3 6.3 10.1 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TRAP_alpha PF03896.16 CCF45794.1 - 8.5 5.5 13.5 12 4.9 13.5 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF4614 PF15391.6 CCF45794.1 - 8.5 6.3 11.0 12 5.8 11.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) NOA36 PF06524.12 CCF45794.1 - 10 5.4 32.1 16 4.7 32.1 1.3 1 0 0 1 1 1 0 NOA36 protein AhpC-TSA PF00578.21 CCF45797.1 - 2.8e-30 104.8 0.0 3.7e-30 104.4 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 CCF45797.1 - 1.1e-13 51.1 0.0 1.5e-13 50.7 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 CCF45797.1 - 2.8e-11 43.1 0.1 5.9e-11 42.0 0.1 1.6 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin Ribosomal_L23eN PF03939.13 CCF45798.1 - 2.5e-23 82.0 6.8 2.5e-23 82.0 6.8 1.9 2 0 0 2 2 2 1 Ribosomal protein L23, N-terminal domain Ribosomal_L23 PF00276.20 CCF45798.1 - 1.5e-15 57.3 0.8 2.9e-15 56.4 0.8 1.6 1 0 0 1 1 1 1 Ribosomal protein L23 zf-Tim10_DDP PF02953.15 CCF45799.1 - 6.9e-18 64.1 1.4 7.8e-18 63.9 1.4 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Pkinase PF00069.25 CCF45801.1 - 2.2e-61 207.6 0.0 3.1e-61 207.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF45801.1 - 1e-32 113.5 0.0 3.1e-30 105.3 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF45801.1 - 2.7e-05 23.6 0.7 0.019 14.3 0.0 2.6 2 1 0 2 2 2 2 Kinase-like Haspin_kinase PF12330.8 CCF45801.1 - 0.0014 17.6 0.1 0.0022 17.0 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 CCF45801.1 - 0.0033 16.8 0.0 0.0052 16.2 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CCF45801.1 - 0.0048 16.9 1.0 0.01 15.8 0.1 1.9 2 0 0 2 2 2 1 Phosphotransferase enzyme family FTA2 PF13095.6 CCF45801.1 - 0.011 15.4 0.3 2.2 7.9 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Aldedh PF00171.22 CCF45802.1 - 8.9e-39 133.3 2.7 1.7e-16 59.8 0.2 3.0 1 1 2 3 3 3 3 Aldehyde dehydrogenase family DEK_C PF08766.11 CCF45804.1 - 2.7e-13 49.6 0.5 9.6e-13 47.8 0.6 1.8 2 0 0 2 2 2 1 DEK C terminal domain U1snRNP70_N PF12220.8 CCF45805.1 - 0.049 14.3 0.0 0.051 14.2 0.0 1.1 1 0 0 1 1 1 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal GFA PF04828.14 CCF45806.1 - 8.4e-12 45.3 0.2 1.7e-11 44.3 0.2 1.5 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme D_CNTX PF17492.2 CCF45806.1 - 0.11 12.7 0.1 0.11 12.7 0.1 2.5 2 1 0 2 2 2 0 Delta Ctenitoxins Ferric_reduct PF01794.19 CCF45807.1 - 2.3e-22 79.5 17.5 6.7e-22 77.9 17.5 1.9 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 CCF45807.1 - 1.4e-10 41.3 0.1 1.7e-09 37.7 0.1 2.2 1 1 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 CCF45807.1 - 3.5e-08 33.7 0.0 5.6e-07 29.8 0.0 2.2 1 1 0 1 1 1 1 Ferric reductase NAD binding domain Pam17 PF08566.10 CCF45808.1 - 2.4e-66 222.7 0.0 3.9e-66 222.0 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial import protein Pam17 Med3 PF11593.8 CCF45808.1 - 0.065 12.4 2.0 0.073 12.2 2.0 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Rho_GDI PF02115.17 CCF45810.1 - 3e-33 115.2 5.7 7.6e-32 110.6 5.7 2.0 1 1 0 1 1 1 1 RHO protein GDP dissociation inhibitor SLC12 PF03522.15 CCF45810.1 - 0.0015 17.6 0.2 0.0015 17.6 0.2 1.1 1 0 0 1 1 1 1 Solute carrier family 12 Androgen_recep PF02166.16 CCF45810.1 - 0.037 12.9 0.3 0.048 12.5 0.3 1.1 1 0 0 1 1 1 0 Androgen receptor SprA-related PF12118.8 CCF45810.1 - 0.13 11.4 8.5 0.15 11.2 8.5 1.1 1 0 0 1 1 1 0 SprA-related family DUF2967 PF11179.8 CCF45810.1 - 0.22 9.6 4.7 4 5.4 5.5 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2967) SHR-BD PF06650.12 CCF45813.1 - 6.7e-96 320.8 0.0 1.2e-95 320.0 0.0 1.4 1 0 0 1 1 1 1 SHR-binding domain of vacuolar-sorting associated protein 13 VPS13_C PF16909.5 CCF45813.1 - 1.4e-22 80.4 0.2 2.7e-22 79.4 0.2 1.5 1 0 0 1 1 1 1 Vacuolar-sorting-associated 13 protein C-terminal p450 PF00067.22 CCF45815.1 - 4.8e-58 197.0 0.0 1.1e-55 189.3 0.0 2.9 2 1 0 2 2 2 2 Cytochrome P450 p450 PF00067.22 CCF45816.1 - 8.4e-50 169.8 0.0 1.1e-49 169.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 FTR1 PF03239.14 CCF45818.1 - 8.4e-57 192.7 7.1 9.4e-57 192.5 7.1 1.0 1 0 0 1 1 1 1 Iron permease FTR1 family DUF3054 PF11255.8 CCF45818.1 - 0.05 14.1 6.1 1.1 9.8 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3054) MgtE PF01769.16 CCF45818.1 - 3.8 7.9 12.1 8.2 6.8 2.8 2.4 2 0 0 2 2 2 0 Divalent cation transporter DUF2232 PF09991.9 CCF45818.1 - 6.8 5.8 13.5 1.1 8.4 5.6 2.7 3 0 0 3 3 3 0 Predicted membrane protein (DUF2232) VIR_N PF15912.5 CCF45820.1 - 3.1 7.3 9.9 3.9 7.0 9.9 1.0 1 0 0 1 1 1 0 Virilizer, N-terminal Glyco_hydro_15 PF00723.21 CCF45821.1 - 0.00017 20.5 0.1 0.0002 20.3 0.1 1.3 1 1 0 1 1 1 1 Glycosyl hydrolases family 15 Bromo_TP PF07524.13 CCF45822.1 - 8.1e-09 35.4 0.0 1.4e-08 34.6 0.0 1.3 1 0 0 1 1 1 1 Bromodomain associated TFIID-31kDa PF02291.15 CCF45822.1 - 0.012 15.7 0.0 0.021 14.9 0.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Dynamin_N PF00350.23 CCF45824.1 - 5.1e-06 26.6 1.0 2.6e-05 24.4 0.0 2.3 2 1 0 2 2 2 1 Dynamin family DUF848 PF05852.11 CCF45824.1 - 0.082 13.0 7.6 0.57 10.3 0.6 2.6 1 1 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) Bap31_Bap29_C PF18035.1 CCF45824.1 - 0.12 12.4 4.4 0.6 10.2 0.1 2.7 2 0 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain Pro_dh PF01619.18 CCF45824.1 - 0.17 11.4 2.2 0.37 10.3 2.2 1.5 1 0 0 1 1 1 0 Proline dehydrogenase DUF3450 PF11932.8 CCF45824.1 - 0.17 11.1 6.1 1.3 8.3 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) DASH_Spc34 PF08657.10 CCF45824.1 - 0.2 11.5 6.8 0.41 10.4 6.7 1.4 1 1 0 1 1 1 0 DASH complex subunit Spc34 ZapB PF06005.12 CCF45824.1 - 0.28 11.7 0.0 0.28 11.7 0.0 3.1 3 2 0 3 3 2 0 Cell division protein ZapB FlaC_arch PF05377.11 CCF45824.1 - 0.44 11.0 6.0 0.17 12.3 0.4 2.9 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) ECH_2 PF16113.5 CCF45824.1 - 0.97 8.9 3.8 2.5 7.5 3.8 1.7 1 0 0 1 1 1 0 Enoyl-CoA hydratase/isomerase DivIC PF04977.15 CCF45824.1 - 0.98 9.2 7.1 0.6 9.9 0.3 2.8 2 1 0 2 2 2 0 Septum formation initiator Atg14 PF10186.9 CCF45824.1 - 1.2 8.2 14.3 0.69 8.9 0.1 2.7 3 0 0 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 Cluap1 PF10234.9 CCF45824.1 - 6.7 6.0 9.8 3.6 6.9 4.8 2.2 1 1 0 2 2 2 0 Clusterin-associated protein-1 SMP PF04927.12 CCF45826.1 - 1e-14 54.7 11.4 5.8e-10 39.5 4.6 2.1 2 0 0 2 2 2 2 Seed maturation protein Ifi-6-16 PF06140.13 CCF45826.1 - 0.024 14.5 1.2 0.83 9.6 0.1 2.2 2 0 0 2 2 2 0 Interferon-induced 6-16 family p450 PF00067.22 CCF45829.1 - 4e-25 88.5 0.0 1.5e-24 86.6 0.0 1.9 2 0 0 2 2 2 1 Cytochrome P450 CorA PF01544.18 CCF45831.1 - 0.00067 19.1 2.3 0.0016 17.9 2.3 1.6 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein Trimer_CC PF08954.11 CCF45831.1 - 0.11 12.1 2.2 2.7 7.6 0.3 2.8 2 0 0 2 2 2 0 Trimerisation motif GPI-anchored PF10342.9 CCF45832.1 - 3.9e-17 62.8 2.6 3.9e-17 62.8 2.6 2.3 2 1 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family DUF1455 PF07306.11 CCF45832.1 - 0.16 11.9 7.2 0.25 11.3 5.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1455) GATase_6 PF13522.6 CCF45834.1 - 1.8e-34 118.8 0.0 2.9e-34 118.2 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 CCF45834.1 - 9.5e-34 116.0 0.0 1.4e-33 115.4 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.8 CCF45834.1 - 9.5e-05 21.9 0.0 9.7e-05 21.9 0.0 1.2 1 1 0 1 1 1 1 Aluminium induced protein E1-E2_ATPase PF00122.20 CCF45835.1 - 5.4e-39 133.6 10.9 4.7e-31 107.7 0.0 2.9 2 1 0 3 3 3 2 E1-E2 ATPase Cation_ATPase_N PF00690.26 CCF45835.1 - 2.6e-15 55.8 0.2 6.4e-15 54.6 0.0 1.8 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 CCF45835.1 - 0.034 14.2 0.0 0.067 13.3 0.0 1.5 1 0 0 1 1 1 0 Cation transport ATPase (P-type) Hydrolase PF00702.26 CCF45835.1 - 0.047 14.0 0.0 0.13 12.5 0.0 1.7 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Ank_2 PF12796.7 CCF45836.1 - 7.6e-29 100.1 0.1 6.7e-09 36.2 0.0 5.7 3 2 1 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CCF45836.1 - 8.2e-21 74.1 0.9 1e-09 38.7 0.0 6.6 5 1 2 7 7 7 4 Ankyrin repeats (many copies) Ank PF00023.30 CCF45836.1 - 4.2e-20 71.2 1.9 0.0013 19.1 0.0 6.9 8 0 0 8 8 8 4 Ankyrin repeat Ank_5 PF13857.6 CCF45836.1 - 2.6e-19 69.0 1.7 1.2e-09 38.2 0.0 7.0 5 1 2 7 7 7 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCF45836.1 - 6.8e-19 66.0 1.1 0.035 14.6 0.0 9.4 10 0 0 10 10 10 3 Ankyrin repeat DUF2384 PF09722.10 CCF45836.1 - 0.25 11.4 3.4 2.9 8.0 0.1 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF2384) MFS_1 PF07690.16 CCF45837.1 - 4.4e-34 117.9 21.8 4.4e-34 117.9 21.8 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_4 PF06779.14 CCF45837.1 - 9.7e-07 28.4 0.6 9.7e-07 28.4 0.6 2.5 2 1 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB Spin-Ssty PF02513.17 CCF45837.1 - 0.054 13.2 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 Spin/Ssty Family Phage-Gp8 PF09215.10 CCF45838.1 - 0.13 11.3 0.8 0.15 11.1 0.8 1.0 1 0 0 1 1 1 0 Bacteriophage T4, Gp8 IR1-M PF12185.8 CCF45838.1 - 0.72 9.8 4.0 1.3 9.0 4.0 1.4 1 0 0 1 1 1 0 Nup358/RanBP2 E3 ligase domain AtuA PF07287.11 CCF45839.1 - 1.8e-56 191.4 0.0 2.2e-56 191.1 0.0 1.1 1 0 0 1 1 1 1 Acyclic terpene utilisation family protein AtuA MaoC_dehydrat_N PF13452.6 CCF45840.1 - 0.023 14.8 0.0 0.029 14.5 0.0 1.2 1 0 0 1 1 1 0 N-terminal half of MaoC dehydratase Abhydrolase_1 PF00561.20 CCF45841.1 - 2.2e-15 57.0 0.0 1e-11 45.0 0.1 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_4 PF08386.10 CCF45841.1 - 5e-15 55.5 0.0 2.7e-13 49.9 0.0 2.3 2 0 0 2 2 2 1 TAP-like protein Hydrolase_4 PF12146.8 CCF45841.1 - 0.013 14.8 0.0 0.088 12.1 0.0 2.1 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Zn_clus PF00172.18 CCF45842.1 - 2.4e-06 27.6 8.7 6.3e-06 26.2 8.7 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 CCF45842.1 - 4.7e-05 22.4 0.1 0.0001 21.3 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF2816 PF10992.8 CCF45842.1 - 0.084 12.8 0.1 7.9 6.4 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2816) Sugar_tr PF00083.24 CCF45843.1 - 3e-116 389.0 23.4 5.3e-116 388.1 23.4 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF45843.1 - 5.5e-30 104.5 59.8 4e-25 88.5 28.8 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily AA_permease_2 PF13520.6 CCF45844.1 - 7.1e-21 74.5 29.2 8.2e-21 74.3 29.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CCF45844.1 - 5.3e-15 55.0 26.1 6.1e-15 54.8 26.1 1.0 1 0 0 1 1 1 1 Amino acid permease DUF4350 PF14258.6 CCF45845.1 - 0.0026 18.1 0.1 1.2 9.6 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4350) MFS_1 PF07690.16 CCF45848.1 - 7.7e-06 25.1 0.0 8e-06 25.0 0.0 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Nodulin-like PF06813.13 CCF45848.1 - 0.0065 16.0 0.1 0.0077 15.7 0.1 1.1 1 0 0 1 1 1 1 Nodulin-like MAPEG PF01124.18 CCF45850.1 - 0.0008 19.3 2.1 0.0027 17.6 2.1 1.9 1 1 0 1 1 1 1 MAPEG family UNC-93 PF05978.16 CCF45851.1 - 3.1e-08 33.5 7.5 3.8e-08 33.2 7.5 1.3 1 0 0 1 1 1 1 Ion channel regulatory protein UNC-93 MFS_1 PF07690.16 CCF45851.1 - 3.7e-07 29.4 12.1 6.8e-07 28.5 11.9 1.5 1 1 1 2 2 2 1 Major Facilitator Superfamily DUF3792 PF12670.7 CCF45852.1 - 0.0045 17.1 0.8 1.4 9.1 0.2 2.4 2 1 0 2 2 2 2 Protein of unknown function (DUF3792) MFS_1 PF07690.16 CCF45852.1 - 0.061 12.2 9.4 0.23 10.3 9.4 1.6 1 1 0 1 1 1 0 Major Facilitator Superfamily Pyr_redox_2 PF07992.14 CCF45853.1 - 4.3e-18 65.6 0.0 2.9e-15 56.3 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 CCF45853.1 - 3.1e-12 45.7 0.0 2.5e-10 39.4 0.0 2.1 2 0 0 2 2 2 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 CCF45853.1 - 2e-11 44.0 0.6 7.2e-08 32.5 0.2 2.5 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 CCF45853.1 - 4.7e-11 42.5 0.0 1.5e-09 37.6 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CCF45853.1 - 5.9e-09 35.5 0.2 2e-06 27.2 0.0 2.5 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 CCF45853.1 - 3.2e-06 27.0 6.0 0.082 12.5 0.0 4.0 3 1 0 3 3 3 2 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 CCF45853.1 - 9.1e-05 22.5 2.7 1.8 8.5 0.4 3.8 3 1 0 3 3 3 2 FAD-NAD(P)-binding Thi4 PF01946.17 CCF45853.1 - 0.00097 18.4 1.9 0.15 11.3 0.1 2.4 2 0 0 2 2 2 2 Thi4 family Pyr_redox PF00070.27 CCF45853.1 - 0.0049 17.4 2.4 2.2 8.9 0.0 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CCF45853.1 - 0.0055 15.8 0.3 0.0055 15.8 0.3 1.9 2 0 0 2 2 2 1 FAD binding domain Shikimate_DH PF01488.20 CCF45853.1 - 0.0056 16.7 0.1 0.051 13.6 0.0 2.2 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase FAD_binding_3 PF01494.19 CCF45853.1 - 0.014 14.7 0.8 0.26 10.5 0.1 2.6 3 0 0 3 3 3 0 FAD binding domain NAD_binding_7 PF13241.6 CCF45853.1 - 0.028 14.9 0.0 1.8 9.0 0.0 2.7 2 0 0 2 2 2 0 Putative NAD(P)-binding Lycopene_cycl PF05834.12 CCF45853.1 - 0.13 11.2 2.5 0.61 9.1 0.3 2.7 2 1 0 2 2 2 0 Lycopene cyclase protein 2-Hacid_dh_C PF02826.19 CCF45853.1 - 0.14 11.5 0.0 0.26 10.6 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ThiF PF00899.21 CCF45853.1 - 0.17 11.2 0.8 12 5.1 0.1 2.3 2 0 0 2 2 2 0 ThiF family GIDA PF01134.22 CCF45853.1 - 0.45 9.5 5.8 7.7 5.5 0.0 3.4 4 0 0 4 4 4 0 Glucose inhibited division protein A HI0933_like PF03486.14 CCF45853.1 - 0.52 9.0 4.6 5.3 5.6 0.1 2.7 3 0 0 3 3 3 0 HI0933-like protein FAD_oxidored PF12831.7 CCF45853.1 - 0.76 9.0 4.5 0.36 10.1 1.8 1.9 2 1 0 2 2 2 0 FAD dependent oxidoreductase p450 PF00067.22 CCF45854.1 - 5.4e-30 104.6 0.0 7e-30 104.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 ADH_N PF08240.12 CCF45855.1 - 4e-07 29.9 0.0 6.5e-07 29.2 0.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCF45855.1 - 7.3e-06 26.0 0.0 1.4e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Pec_lyase_C PF00544.19 CCF45856.1 - 7.7e-42 143.3 7.0 1.1e-41 142.7 7.0 1.3 1 0 0 1 1 1 1 Pectate lyase Beta_helix PF13229.6 CCF45856.1 - 8.4e-05 22.5 8.8 0.00039 20.3 1.4 2.3 1 1 1 2 2 2 2 Right handed beta helix region Zn_clus PF00172.18 CCF45859.1 - 1.2e-07 31.7 6.5 2.4e-07 30.8 6.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TIP49 PF06068.13 CCF45860.1 - 2.6e-154 513.6 2.3 3.2e-154 513.3 2.3 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 CCF45860.1 - 8.3e-21 73.9 0.2 4.2e-20 71.6 0.2 2.3 2 0 0 2 2 2 1 TIP49 AAA-lid domain RuvB_N PF05496.12 CCF45860.1 - 4.8e-09 36.2 0.4 3.2e-05 23.7 0.0 2.5 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA PF00004.29 CCF45860.1 - 2.2e-08 34.6 0.8 5e-05 23.7 0.0 3.3 2 1 1 3 3 3 2 ATPase family associated with various cellular activities (AAA) DnaB_C PF03796.15 CCF45860.1 - 3.8e-06 26.4 0.9 7.1e-06 25.5 0.9 1.4 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_16 PF13191.6 CCF45860.1 - 2.8e-05 24.5 0.1 7.2e-05 23.2 0.1 1.8 1 1 0 1 1 1 1 AAA ATPase domain Mg_chelatase PF01078.21 CCF45860.1 - 0.0011 18.4 0.8 0.021 14.2 0.3 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 CCF45860.1 - 0.0055 16.4 0.0 2.2 8.0 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_19 PF13245.6 CCF45860.1 - 0.0086 16.4 2.1 0.66 10.3 2.1 2.7 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CCF45860.1 - 0.01 16.1 0.0 0.71 10.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_11 PF13086.6 CCF45860.1 - 0.016 15.0 0.9 0.11 12.3 0.1 2.1 1 1 1 2 2 2 0 AAA domain AAA_5 PF07728.14 CCF45860.1 - 0.023 14.7 0.1 3.5 7.6 0.0 2.7 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) Parvo_NS1 PF01057.17 CCF45860.1 - 0.035 13.2 0.0 0.06 12.4 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_25 PF13481.6 CCF45860.1 - 0.048 13.2 0.1 0.092 12.3 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 CCF45860.1 - 0.1 12.1 0.1 0.43 10.1 0.0 2.0 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_33 PF13671.6 CCF45860.1 - 0.11 12.6 0.0 0.47 10.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 CCF45860.1 - 0.13 12.5 0.0 0.29 11.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain ORC5_C PF14630.6 CCF45861.1 - 9.8e-46 156.5 0.1 1.7e-45 155.7 0.0 1.4 2 0 0 2 2 2 1 Origin recognition complex (ORC) subunit 5 C-terminus AAA_16 PF13191.6 CCF45861.1 - 1.6e-16 61.1 0.0 3.2e-16 60.2 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 CCF45861.1 - 0.0012 19.1 0.0 0.0045 17.3 0.0 1.9 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.13 CCF45861.1 - 0.029 13.5 0.0 0.071 12.3 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF815) KAP_NTPase PF07693.14 CCF45861.1 - 0.041 13.1 0.0 0.13 11.5 0.0 1.7 1 1 1 2 2 2 0 KAP family P-loop domain TniB PF05621.11 CCF45861.1 - 0.054 12.9 0.0 0.087 12.2 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein ATPase_2 PF01637.18 CCF45861.1 - 0.18 11.7 0.0 0.25 11.2 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Abhydrolase_2 PF02230.16 CCF45862.1 - 2.1e-22 80.0 0.0 5.2e-15 55.8 0.0 2.1 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 CCF45862.1 - 0.024 14.1 0.1 0.14 11.6 0.1 2.3 2 1 0 2 2 2 0 Prolyl oligopeptidase family CFEM PF05730.11 CCF45863.1 - 0.0032 17.5 1.4 0.0032 17.5 1.4 1.5 2 0 0 2 2 2 1 CFEM domain FAD-oxidase_C PF02913.19 CCF45865.1 - 2.5e-63 214.1 0.6 2.5e-63 214.1 0.6 1.8 2 0 0 2 2 2 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 CCF45865.1 - 4.5e-37 126.9 0.0 1e-36 125.8 0.0 1.6 1 0 0 1 1 1 1 FAD binding domain Clr5 PF14420.6 CCF45866.1 - 1.9e-17 63.2 0.7 1.9e-17 63.2 0.7 2.9 4 0 0 4 4 4 1 Clr5 domain TAXi_C PF14541.6 CCF45866.1 - 0.11 12.3 0.1 0.26 11.0 0.0 1.7 2 0 0 2 2 2 0 Xylanase inhibitor C-terminal CDT1_C PF16679.5 CCF45866.1 - 0.17 12.3 0.9 6.8 7.2 0.0 3.2 3 1 0 3 3 3 0 DNA replication factor Cdt1 C-terminal domain ECH_1 PF00378.20 CCF45867.1 - 1.9e-38 132.2 0.0 2.5e-38 131.9 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CCF45867.1 - 7.2e-23 81.6 0.0 1e-22 81.1 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase LppA PF16708.5 CCF45867.1 - 0.02 14.8 0.0 0.033 14.1 0.0 1.3 1 0 0 1 1 1 0 Lipoprotein confined to pathogenic Mycobacterium SPRY PF00622.28 CCF45868.1 - 3.5e-07 30.4 0.0 6.9e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 SPRY domain Glyco_transf_4 PF13439.6 CCF45870.1 - 0.084 12.9 0.8 0.089 12.8 0.8 1.3 1 1 0 1 1 1 0 Glycosyltransferase Family 4 YL1 PF05764.13 CCF45872.1 - 0.014 15.5 7.2 0.015 15.5 7.2 1.1 1 0 0 1 1 1 0 YL1 nuclear protein Herpes_UL32 PF06070.11 CCF45872.1 - 0.046 11.5 2.4 0.051 11.3 2.4 1.0 1 0 0 1 1 1 0 Herpesvirus large structural phosphoprotein UL32 CCDC106 PF15794.5 CCF45872.1 - 0.12 12.1 2.0 0.13 11.9 2.0 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Lyase_aromatic PF00221.19 CCF45874.1 - 2.9e-30 105.4 0.2 4e-30 104.9 0.2 1.1 1 0 0 1 1 1 1 Aromatic amino acid lyase Glyco_hydro_3_C PF01915.22 CCF45875.1 - 1.1e-22 81.1 0.0 1.5e-22 80.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 CCF45875.1 - 5.1e-09 36.1 0.0 1e-08 35.1 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain PAC3 PF10178.9 CCF45876.1 - 4.3e-06 26.8 0.0 5.2e-06 26.5 0.0 1.1 1 0 0 1 1 1 1 Proteasome assembly chaperone 3 Hexapep PF00132.24 CCF45877.1 - 1.9e-15 55.9 8.9 2e-12 46.3 2.7 3.6 2 1 0 2 2 2 2 Bacterial transferase hexapeptide (six repeats) Mac PF12464.8 CCF45877.1 - 5.6e-14 52.1 0.0 8.6e-14 51.5 0.0 1.3 1 0 0 1 1 1 1 Maltose acetyltransferase Hexapep_2 PF14602.6 CCF45877.1 - 3.5e-10 39.5 2.8 3.5e-10 39.5 2.8 3.1 4 0 0 4 4 4 1 Hexapeptide repeat of succinyl-transferase Pro_isomerase PF00160.21 CCF45878.1 - 5.8e-51 172.9 0.0 6.6e-51 172.7 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Aft1_HRR PF11787.8 CCF45879.1 - 0.014 16.5 0.8 0.014 16.5 0.8 2.1 2 1 0 2 2 2 0 Aft1 HRR domain SNARE_assoc PF09335.11 CCF45880.1 - 4.7e-12 46.5 5.8 4.7e-12 46.5 5.8 2.1 2 0 0 2 2 2 1 SNARE associated Golgi protein DUF2417 PF10329.9 CCF45880.1 - 0.21 11.0 0.8 0.34 10.3 0.8 1.2 1 0 0 1 1 1 0 Region of unknown function (DUF2417) FUSC-like PF12805.7 CCF45880.1 - 1 8.3 4.2 1.8 7.6 4.2 1.3 1 0 0 1 1 1 0 FUSC-like inner membrane protein yccS DUF1771 PF08590.10 CCF45881.1 - 8.6e-15 54.9 11.6 8.6e-15 54.9 11.6 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF1771) zf_CCCH_4 PF18345.1 CCF45881.1 - 1.9e-08 34.0 8.3 4.6e-06 26.5 0.6 2.9 2 1 0 2 2 2 2 Zinc finger domain Smr PF01713.21 CCF45881.1 - 2.9e-07 30.8 0.1 1.1e-06 28.9 0.0 2.0 2 0 0 2 2 2 1 Smr domain zf-CCCH PF00642.24 CCF45881.1 - 1.2e-06 28.2 3.3 0.0011 18.8 0.4 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 CCF45881.1 - 0.00014 21.5 11.8 0.0015 18.3 0.4 3.1 2 1 0 2 2 2 1 CCCH-type zinc finger zf-CCCH_2 PF14608.6 CCF45881.1 - 0.00015 22.1 4.9 0.11 13.0 0.8 2.4 2 0 0 2 2 2 2 RNA-binding, Nab2-type zinc finger HBS1_N PF08938.10 CCF45881.1 - 0.012 15.9 0.0 0.033 14.5 0.0 1.7 1 0 0 1 1 1 0 HBS1 N-terminus zf-CCCH_3 PF15663.5 CCF45881.1 - 0.054 13.7 2.4 3 8.1 0.1 2.3 1 1 1 2 2 2 0 Zinc-finger containing family Torus PF16131.5 CCF45881.1 - 0.8 10.4 5.0 2.4 8.9 0.4 2.4 1 1 1 2 2 2 0 Torus domain Cupin_8 PF13621.6 CCF45882.1 - 1.8e-19 70.4 0.1 3.6e-18 66.2 0.1 2.1 1 1 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 CCF45882.1 - 3.9e-10 40.2 0.1 1.2e-09 38.6 0.1 1.9 1 1 0 1 1 1 1 JmjC domain, hydroxylase F-box-like PF12937.7 CCF45882.1 - 6.3e-05 22.8 0.2 0.00013 21.8 0.2 1.6 1 0 0 1 1 1 1 F-box-like Cupin_4 PF08007.12 CCF45882.1 - 0.0084 15.6 0.0 0.015 14.8 0.0 1.3 1 0 0 1 1 1 1 Cupin superfamily protein F-box PF00646.33 CCF45882.1 - 0.017 15.0 0.9 0.037 13.9 0.9 1.6 1 0 0 1 1 1 0 F-box domain ScsC_N PF18312.1 CCF45882.1 - 0.058 13.2 0.9 0.11 12.4 0.9 1.4 1 0 0 1 1 1 0 Copper resistance protein ScsC N-terminal domain Peptidase_S8 PF00082.22 CCF45883.1 - 3.5e-15 56.0 4.5 4.2e-15 55.8 4.5 1.1 1 0 0 1 1 1 1 Subtilase family DNA_pol_P_Exo PF18049.1 CCF45883.1 - 0.092 12.1 0.0 0.12 11.8 0.0 1.1 1 0 0 1 1 1 0 DNA polymerase nu pseudo-exo p450 PF00067.22 CCF45885.1 - 8.7e-14 51.1 0.0 8.7e-14 51.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 YppG PF14179.6 CCF45886.1 - 9.7 7.0 12.2 11 6.8 12.2 1.0 1 0 0 1 1 1 0 YppG-like protein ChaC PF04752.12 CCF45887.1 - 8.4e-38 130.2 0.0 1.1e-37 129.8 0.0 1.1 1 0 0 1 1 1 1 ChaC-like protein Zip PF02535.22 CCF45888.1 - 5e-15 55.6 0.2 6e-15 55.3 0.2 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter DUF772 PF05598.11 CCF45888.1 - 0.1 12.6 0.0 0.12 12.4 0.0 1.1 1 0 0 1 1 1 0 Transposase domain (DUF772) Fungal_trans PF04082.18 CCF45890.1 - 1.3e-19 70.3 0.9 1.4e-19 70.2 0.2 1.4 2 0 0 2 2 2 1 Fungal specific transcription factor domain URO-D PF01208.17 CCF45891.1 - 0.00017 20.8 0.0 0.00018 20.8 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) Sugar_tr PF00083.24 CCF45894.1 - 5.1e-07 28.9 1.3 6.9e-07 28.5 1.3 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter ABC_tran PF00005.27 CCF45895.1 - 8.6e-43 146.1 0.0 3.7e-25 89.0 0.0 3.1 3 0 0 3 3 3 2 ABC transporter ABC_membrane PF00664.23 CCF45895.1 - 9.3e-32 110.8 11.1 9.3e-32 110.8 11.1 2.4 2 0 0 2 2 2 1 ABC transporter transmembrane region SMC_N PF02463.19 CCF45895.1 - 1.6e-11 44.0 3.3 0.012 15.1 0.1 4.2 4 0 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CCF45895.1 - 2.3e-07 30.4 1.9 0.0012 18.6 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.6 CCF45895.1 - 1.2e-06 28.6 4.1 0.27 11.0 0.0 4.3 3 1 1 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 CCF45895.1 - 4.5e-06 27.1 0.1 0.015 15.7 0.1 2.7 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 CCF45895.1 - 4.6e-06 27.0 0.7 0.17 12.2 0.1 3.1 2 2 0 2 2 2 2 AAA domain T2SSE PF00437.20 CCF45895.1 - 5.1e-05 22.5 1.4 0.14 11.2 0.1 2.4 2 0 0 2 2 2 2 Type II/IV secretion system protein RsgA_GTPase PF03193.16 CCF45895.1 - 8.5e-05 22.5 0.7 0.4 10.6 0.1 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_23 PF13476.6 CCF45895.1 - 9.8e-05 22.9 1.5 0.012 16.1 0.3 2.4 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 CCF45895.1 - 0.00018 21.2 2.4 0.21 11.2 0.7 2.5 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain AAA_7 PF12775.7 CCF45895.1 - 0.00068 19.2 0.7 0.43 10.1 0.0 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region IstB_IS21 PF01695.17 CCF45895.1 - 0.00084 19.1 4.1 1.3 8.7 0.0 3.9 4 0 0 4 4 4 1 IstB-like ATP binding protein AAA PF00004.29 CCF45895.1 - 0.0009 19.7 0.5 0.27 11.6 0.1 3.2 2 2 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 CCF45895.1 - 0.0036 17.5 0.3 0.55 10.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain SbcCD_C PF13558.6 CCF45895.1 - 0.0042 17.3 0.0 2.7 8.3 0.0 3.2 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_5 PF07728.14 CCF45895.1 - 0.0074 16.3 0.6 2.3 8.2 0.0 3.5 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) ATP_bind_1 PF03029.17 CCF45895.1 - 0.0079 16.0 3.3 0.15 11.8 0.1 3.2 3 0 0 3 3 3 1 Conserved hypothetical ATP binding protein DEAD PF00270.29 CCF45895.1 - 0.016 15.0 3.1 3.8 7.2 0.0 3.2 3 0 0 3 3 3 0 DEAD/DEAH box helicase AAA_24 PF13479.6 CCF45895.1 - 0.034 13.8 0.2 0.36 10.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 CCF45895.1 - 0.04 14.4 1.1 1 9.9 0.0 2.5 2 0 0 2 2 2 0 AAA domain Roc PF08477.13 CCF45895.1 - 0.043 14.0 0.3 2.6 8.3 0.1 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_25 PF13481.6 CCF45895.1 - 0.056 13.0 1.3 2.4 7.7 0.0 2.8 3 0 0 3 3 3 0 AAA domain NACHT PF05729.12 CCF45895.1 - 0.058 13.3 2.3 5.5 6.9 0.0 2.6 2 0 0 2 2 2 0 NACHT domain TrwB_AAD_bind PF10412.9 CCF45895.1 - 0.062 12.2 1.4 1.3 7.9 0.0 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain NTPase_1 PF03266.15 CCF45895.1 - 0.064 13.2 5.0 5.5 6.9 0.0 3.3 3 0 0 3 3 3 0 NTPase AAA_19 PF13245.6 CCF45895.1 - 0.078 13.3 0.4 9.2 6.6 0.0 2.7 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 CCF45895.1 - 0.12 12.8 0.1 10 6.6 0.0 3.1 3 0 0 3 3 3 0 RNA helicase ATPase_2 PF01637.18 CCF45895.1 - 0.13 12.1 0.1 21 4.9 0.0 2.4 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_30 PF13604.6 CCF45895.1 - 0.16 11.7 4.5 6 6.5 0.3 3.1 2 1 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 CCF45895.1 - 0.33 11.1 1.8 24 5.0 0.2 2.8 2 1 0 2 2 2 0 50S ribosome-binding GTPase TsaE PF02367.17 CCF45895.1 - 0.36 10.8 1.2 12 6.0 0.0 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Dynamin_N PF00350.23 CCF45895.1 - 0.48 10.5 6.6 0.49 10.4 0.2 2.7 3 0 0 3 3 2 0 Dynamin family TPR_12 PF13424.6 CCF45896.1 - 2.2e-09 37.4 12.3 2.2e-06 27.8 3.5 4.0 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 CCF45896.1 - 1.9e-07 30.6 6.9 0.069 13.3 0.1 4.8 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 CCF45896.1 - 3.8e-05 23.6 1.3 1.3 9.4 0.0 4.6 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 CCF45896.1 - 5.8e-05 22.7 0.8 0.65 9.9 0.0 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 CCF45896.1 - 0.0002 21.8 4.8 2.1 9.2 0.0 5.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_MalT PF17874.1 CCF45896.1 - 0.0054 16.2 5.4 0.16 11.3 1.6 2.4 2 0 0 2 2 2 2 MalT-like TPR region TPR_14 PF13428.6 CCF45896.1 - 0.012 16.4 0.1 0.012 16.4 0.1 5.2 3 2 2 5 5 5 0 Tetratricopeptide repeat TPR_10 PF13374.6 CCF45896.1 - 0.021 14.7 9.9 4.3 7.3 0.1 4.7 4 0 0 4 4 4 0 Tetratricopeptide repeat Ank_2 PF12796.7 CCF45896.1 - 0.025 15.1 0.0 0.14 12.8 0.0 2.2 2 1 0 2 2 2 0 Ankyrin repeats (3 copies) TPR_7 PF13176.6 CCF45896.1 - 0.062 13.4 12.4 1.2 9.3 0.1 4.8 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_4 PF07721.14 CCF45896.1 - 0.093 13.4 19.5 0.56 11.0 0.2 5.2 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_16 PF13432.6 CCF45896.1 - 0.12 13.1 14.7 0.31 11.7 2.8 4.1 2 2 2 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 CCF45896.1 - 5.7 7.5 7.7 2.6 8.6 0.1 3.9 3 2 1 4 4 4 0 Tetratricopeptide repeat Ras PF00071.22 CCF45898.1 - 1.7e-47 161.0 0.0 2.4e-47 160.6 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCF45898.1 - 5.7e-20 71.7 0.0 1.1e-19 70.9 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCF45898.1 - 6.7e-05 22.4 0.0 0.00012 21.6 0.0 1.6 1 1 0 1 1 1 1 ADP-ribosylation factor family AAA_7 PF12775.7 CCF45898.1 - 0.078 12.5 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Ras PF00071.22 CCF45899.1 - 1.6e-49 167.6 2.0 3.1e-47 160.2 0.8 2.0 2 0 0 2 2 2 2 Ras family Roc PF08477.13 CCF45899.1 - 5.8e-28 97.5 0.4 1.1e-24 87.0 0.2 2.6 3 0 0 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCF45899.1 - 8e-11 41.7 0.1 1.6e-10 40.7 0.1 1.5 2 0 0 2 2 2 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 CCF45899.1 - 2.1e-07 30.7 0.0 2.6e-07 30.4 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 CCF45899.1 - 0.00082 18.8 0.1 0.0016 17.8 0.0 1.5 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 CCF45899.1 - 0.001 19.0 0.3 0.043 13.7 0.2 2.4 2 1 1 3 3 3 1 RsgA GTPase GbpA_2 PF18416.1 CCF45899.1 - 0.19 12.0 1.2 7.9 6.8 1.2 2.3 1 1 0 1 1 1 0 N-acetylglucosamine binding protein domain 2 Amidohydro_2 PF04909.14 CCF45900.1 - 7.1e-31 108.1 0.1 9.4e-31 107.7 0.1 1.2 1 0 0 1 1 1 1 Amidohydrolase TatD_DNase PF01026.21 CCF45900.1 - 0.0071 15.7 0.0 0.018 14.4 0.0 1.6 2 0 0 2 2 2 1 TatD related DNase TNFR_16_TM PF18422.1 CCF45901.1 - 0.098 12.6 0.3 0.21 11.6 0.3 1.5 1 0 0 1 1 1 0 Tumor necrosis factor receptor member 16 trans-membrane domain DUF4698 PF15769.5 CCF45902.1 - 0.084 11.9 0.1 0.093 11.8 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4698) GATase_5 PF13507.6 CCF45903.1 - 1.2e-32 113.1 0.2 1.7e-32 112.5 0.2 1.3 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain AIRS_C PF02769.22 CCF45903.1 - 1.5e-10 41.5 0.0 2.9e-10 40.5 0.0 1.5 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain SOR_SNZ PF01680.17 CCF45904.1 - 4.5e-23 82.1 1.2 5.5e-23 81.8 1.2 1.0 1 0 0 1 1 1 1 SOR/SNZ family RNA_pol_Rpb5_N PF03871.14 CCF45905.1 - 3.4e-26 91.6 0.0 5.1e-26 91.1 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb5, N-terminal domain RNA_pol_Rpb5_C PF01191.19 CCF45905.1 - 1.6e-11 43.9 0.0 3.1e-11 43.0 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain DUF4407 PF14362.6 CCF45906.1 - 4.6 6.5 9.4 5 6.4 9.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Sec2p PF06428.11 CCF45907.1 - 4.5e-27 93.8 27.0 4.6e-27 93.8 18.1 2.3 2 0 0 2 2 2 1 GDP/GTP exchange factor Sec2p CENP-Q PF13094.6 CCF45907.1 - 0.018 15.3 1.1 0.018 15.3 1.1 3.0 1 1 2 3 3 3 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF3348 PF11828.8 CCF45907.1 - 0.24 11.0 12.8 1.6 8.3 10.7 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3348) GCN5L1 PF06320.13 CCF45907.1 - 0.27 11.4 13.8 0.034 14.3 8.2 2.0 2 0 0 2 2 2 0 GCN5-like protein 1 (GCN5L1) SlyX PF04102.12 CCF45907.1 - 1.3 9.7 15.4 3.8 8.2 1.7 3.0 2 1 1 3 3 3 0 SlyX KfrA_N PF11740.8 CCF45907.1 - 1.6 9.4 19.2 1.2 9.9 2.9 2.9 2 0 0 2 2 2 0 Plasmid replication region DNA-binding N-term Fib_alpha PF08702.10 CCF45907.1 - 2.5 8.3 17.1 7.4 6.8 7.0 2.2 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF2220 PF09983.9 CCF45907.1 - 2.6 7.4 9.0 1.3 8.4 6.4 1.9 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria C-term(DUF2220) Peptidase_S46 PF10459.9 CCF45907.1 - 9.5 4.7 12.6 13 4.2 12.6 1.1 1 0 0 1 1 1 0 Peptidase S46 V_ATPase_I PF01496.19 CCF45907.1 - 9.6 4.0 11.4 15 3.4 11.4 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Nucleocapsid-N PF11030.8 CCF45909.1 - 0.21 11.5 2.7 0.29 11.1 2.7 1.2 1 0 0 1 1 1 0 Nucleocapsid protein N ALMT PF11744.8 CCF45909.1 - 2.7 6.7 7.0 3.4 6.4 7.0 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter p450 PF00067.22 CCF45912.1 - 9e-42 143.4 0.0 1.1e-41 143.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 EMP70 PF02990.16 CCF45913.1 - 3.2e-103 346.2 33.6 4.2e-103 345.8 33.6 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 DUF2065 PF09838.9 CCF45914.1 - 0.0046 16.9 0.2 0.011 15.7 0.2 1.6 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2065) RGS PF00615.19 CCF45914.1 - 0.018 15.3 0.0 0.048 13.9 0.0 1.6 2 0 0 2 2 2 0 Regulator of G protein signaling domain TMEM43 PF07787.12 CCF45914.1 - 0.062 12.7 0.0 0.1 12.0 0.0 1.3 1 0 0 1 1 1 0 Transmembrane protein 43 Helicase_C PF00271.31 CCF45916.1 - 0.0021 18.4 0.0 0.0037 17.6 0.0 1.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Hexapep PF00132.24 CCF45917.1 - 1.1e-08 34.5 7.7 3.8e-05 23.2 4.0 4.6 3 1 1 4 4 4 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 CCF45917.1 - 0.0001 21.9 1.8 0.0058 16.4 0.9 3.0 2 1 2 4 4 4 3 Hexapeptide repeat of succinyl-transferase Fucokinase PF07959.12 CCF45917.1 - 0.043 12.7 0.0 0.061 12.3 0.0 1.1 1 0 0 1 1 1 0 L-fucokinase Meth_synt_2 PF01717.18 CCF45918.1 - 3.2e-06 26.6 0.0 0.00016 21.1 0.0 2.2 2 1 0 2 2 2 2 Cobalamin-independent synthase, Catalytic domain AP1AR PF15745.5 CCF45918.1 - 0.06 13.0 0.1 0.11 12.1 0.1 1.3 1 0 0 1 1 1 0 AP-1 complex-associated regulatory protein F-box-like PF12937.7 CCF45919.1 - 6.5e-09 35.5 3.2 4.1e-08 33.0 3.2 2.4 1 1 0 1 1 1 1 F-box-like F-box PF00646.33 CCF45919.1 - 0.00065 19.5 5.6 0.086 12.7 6.0 3.2 2 1 0 2 2 2 1 F-box domain GATase_5 PF13507.6 CCF45921.1 - 1.2e-89 299.9 0.0 1.4e-89 299.7 0.0 1.0 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain YrbL-PhoP_reg PF10707.9 CCF45922.1 - 0.082 12.4 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL DUF488 PF04343.13 CCF45923.1 - 0.74 10.4 4.7 0.99 10.0 0.6 2.1 1 1 1 2 2 2 0 Protein of unknown function, DUF488 Zn_clus PF00172.18 CCF45925.1 - 3.5e-08 33.4 11.3 5.7e-08 32.8 11.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain UBX PF00789.20 CCF45926.1 - 6e-13 48.8 0.0 1e-12 48.0 0.0 1.4 1 0 0 1 1 1 1 UBX domain Thioredoxin_7 PF13899.6 CCF45926.1 - 0.015 15.5 0.9 0.048 13.8 0.0 2.3 2 0 0 2 2 2 0 Thioredoxin-like TFIIA PF03153.13 CCF45926.1 - 0.023 14.7 6.9 0.026 14.5 6.9 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF2052 PF09747.9 CCF45926.1 - 3.1 7.9 14.5 6.2 6.9 14.5 1.4 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) PRTP PF01366.18 CCF45926.1 - 4.1 5.3 8.8 5.5 4.9 8.8 1.1 1 0 0 1 1 1 0 Herpesvirus processing and transport protein Borrelia_P83 PF05262.11 CCF45926.1 - 5.9 5.3 17.5 8.2 4.8 17.5 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein Draxin PF15550.6 CCF45926.1 - 6.9 6.4 10.3 10 5.9 10.3 1.3 1 0 0 1 1 1 0 Draxin VIR_N PF15912.5 CCF45926.1 - 8.3 5.9 10.9 13 5.3 10.9 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal FAM216B PF15107.6 CCF45927.1 - 0.072 13.0 0.0 0.077 12.9 0.0 1.2 1 0 0 1 1 1 0 FAM216B protein family TPR_19 PF14559.6 CCF45928.1 - 0.043 14.3 0.2 0.051 14.1 0.2 1.2 1 0 0 1 1 1 0 Tetratricopeptide repeat Peptidase_S8 PF00082.22 CCF45929.1 - 1.1e-42 146.4 0.2 1.8e-42 145.7 0.2 1.4 1 0 0 1 1 1 1 Subtilase family fn3_5 PF06280.12 CCF45929.1 - 2.4e-09 37.9 0.0 7.6e-09 36.3 0.0 1.8 2 0 0 2 2 2 1 Fn3-like domain PA PF02225.22 CCF45929.1 - 0.0051 16.8 0.0 0.018 15.1 0.0 1.9 1 0 0 1 1 1 1 PA domain PGM1_C PF18105.1 CCF45930.1 - 0.1 12.2 0.0 0.29 10.7 0.0 1.7 2 0 0 2 2 2 0 PGM1 C-terminal domain DUF3328 PF11807.8 CCF45931.1 - 1e-19 71.2 0.3 1.3e-19 70.8 0.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) DUF3328 PF11807.8 CCF45932.1 - 6.4e-05 22.8 0.0 8.8e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) ToxB_N PF18224.1 CCF45936.1 - 4.4e-28 97.0 0.1 5.3e-28 96.8 0.1 1.1 1 0 0 1 1 1 1 ToxB N-terminal domain R3H PF01424.22 CCF45937.1 - 2.9e-16 59.2 0.2 5.7e-16 58.3 0.2 1.5 1 0 0 1 1 1 1 R3H domain zf-NF-X1 PF01422.17 CCF45937.1 - 9e-07 28.8 32.1 2.9e-05 24.0 12.4 9.8 11 1 0 11 11 11 3 NF-X1 type zinc finger Glucosamine_iso PF01182.20 CCF45939.1 - 5.5e-40 137.6 0.0 6e-40 137.5 0.0 1.0 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Zn_clus PF00172.18 CCF45940.1 - 1 9.5 10.9 2.1 8.6 3.8 2.4 1 1 1 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Pox_A_type_inc PF04508.12 CCF45942.1 - 0.0025 17.6 1.1 0.0061 16.4 1.1 1.7 1 0 0 1 1 1 1 Viral A-type inclusion protein repeat PriC PF07445.12 CCF45942.1 - 0.0064 16.4 0.3 0.0064 16.4 0.3 1.5 2 0 0 2 2 2 1 Primosomal replication protein priC SlyX PF04102.12 CCF45942.1 - 0.013 16.0 6.8 0.94 10.1 3.5 2.5 2 0 0 2 2 2 0 SlyX Shugoshin_N PF07558.11 CCF45942.1 - 0.023 14.5 0.1 0.054 13.4 0.1 1.6 1 0 0 1 1 1 0 Shugoshin N-terminal coiled-coil region TFIIA PF03153.13 CCF45942.1 - 2.7 7.9 9.3 3 7.7 9.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit JAKMIP_CC3 PF16034.5 CCF45942.1 - 5.2 7.0 8.2 28 4.6 8.2 1.9 1 1 0 1 1 1 0 JAKMIP CC3 domain DivIC PF04977.15 CCF45942.1 - 7.8 6.4 7.8 2.9 7.7 0.1 2.3 2 0 0 2 2 2 0 Septum formation initiator HET PF06985.11 CCF45944.1 - 0.15 12.4 0.6 5.7 7.3 0.0 2.6 1 1 0 2 2 2 0 Heterokaryon incompatibility protein (HET) Pkinase PF00069.25 CCF45945.1 - 1.5e-09 37.6 0.0 4.2e-06 26.3 0.0 2.3 2 1 0 2 2 2 2 Protein kinase domain Choline_kinase PF01633.20 CCF45945.1 - 2.8e-05 23.8 0.0 4.3e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase Pkinase_Tyr PF07714.17 CCF45945.1 - 4.3e-05 22.9 0.2 0.0014 17.9 0.1 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 CCF45945.1 - 0.001 19.1 1.9 0.0013 18.7 0.2 1.8 2 0 0 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 CCF45945.1 - 0.027 14.1 0.1 0.082 12.5 0.0 1.7 2 0 0 2 2 2 0 RIO1 family rhaM PF05336.13 CCF45945.1 - 0.052 13.6 0.4 0.098 12.7 0.4 1.5 1 0 0 1 1 1 0 L-rhamnose mutarotase Pox_ser-thr_kin PF05445.11 CCF45945.1 - 0.19 10.7 0.0 0.22 10.5 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Haspin_kinase PF12330.8 CCF45945.1 - 0.23 10.3 0.0 0.31 9.9 0.0 1.1 1 0 0 1 1 1 0 Haspin like kinase domain CN_hydrolase PF00795.22 CCF45946.1 - 2.7e-11 43.3 0.0 3.1e-11 43.1 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase DEAD PF00270.29 CCF45947.1 - 8.8e-07 28.9 0.0 2.1e-06 27.7 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 CCF45947.1 - 3.2e-05 24.2 0.4 0.00011 22.5 0.0 2.0 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.6 CCF45947.1 - 0.00022 21.6 0.0 0.00044 20.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CCF45947.1 - 0.0008 19.2 0.1 0.0016 18.2 0.1 1.4 1 0 0 1 1 1 1 AAA domain SDA1 PF05285.12 CCF45947.1 - 0.0039 16.7 13.0 0.0039 16.7 13.0 2.4 2 1 0 2 2 2 1 SDA1 T2SSE PF00437.20 CCF45947.1 - 0.0072 15.4 0.1 0.024 13.7 0.0 1.8 2 0 0 2 2 2 1 Type II/IV secretion system protein ResIII PF04851.15 CCF45947.1 - 0.013 15.6 1.1 2.3 8.2 0.0 3.0 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit ATPase PF06745.13 CCF45947.1 - 0.014 14.8 0.0 0.027 13.8 0.0 1.5 1 0 0 1 1 1 0 KaiC PhoH PF02562.16 CCF45947.1 - 0.014 14.8 0.1 0.05 13.1 0.0 1.8 2 0 0 2 2 2 0 PhoH-like protein DUF2075 PF09848.9 CCF45947.1 - 0.03 13.6 0.6 0.078 12.2 0.0 1.9 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) FtsK_SpoIIIE PF01580.18 CCF45947.1 - 0.056 12.8 0.0 0.1 11.9 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_33 PF13671.6 CCF45947.1 - 0.074 13.2 0.2 0.22 11.7 0.0 1.9 2 0 0 2 2 2 0 AAA domain Tyrosinase PF00264.20 CCF45948.1 - 9.5e-35 120.9 2.3 1.2e-34 120.5 2.3 1.1 1 0 0 1 1 1 1 Common central domain of tyrosinase RTA1 PF04479.13 CCF45949.1 - 2.3e-65 220.1 16.5 2.3e-65 220.1 16.5 1.9 1 1 1 2 2 2 1 RTA1 like protein Kei1 PF08552.11 CCF45949.1 - 0.002 18.0 2.2 0.0032 17.4 0.0 2.3 3 0 0 3 3 3 1 Inositolphosphorylceramide synthase subunit Kei1 Caveolin PF01146.17 CCF45949.1 - 0.96 9.4 4.8 0.37 10.7 0.4 2.4 2 0 0 2 2 2 0 Caveolin PALP PF00291.25 CCF45951.1 - 9.6e-29 100.7 0.0 3.8e-28 98.8 0.0 1.7 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Rhodanese PF00581.20 CCF45951.1 - 1.6e-06 28.5 0.0 5.1e-06 27.0 0.0 1.8 1 1 0 1 1 1 1 Rhodanese-like domain Asparaginase PF00710.20 CCF45952.1 - 1.5e-28 99.7 0.0 2.5e-28 98.9 0.0 1.3 1 0 0 1 1 1 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 CCF45952.1 - 3.7e-16 59.4 0.1 6.5e-16 58.6 0.1 1.4 1 0 0 1 1 1 1 Glutaminase/Asparaginase C-terminal domain Acyl-CoA_dh_1 PF00441.24 CCF45955.1 - 5.7e-22 78.5 0.2 8.7e-22 77.9 0.2 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 CCF45955.1 - 1.6e-21 77.1 0.3 3.3e-21 76.0 0.3 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 CCF45955.1 - 1.7e-16 60.1 0.0 3.6e-16 59.1 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 CCF45955.1 - 2.5e-05 24.5 0.3 4.6e-05 23.7 0.3 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Glyco_hydro_3_C PF01915.22 CCF45957.1 - 2e-48 165.1 0.0 3.1e-48 164.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 CCF45957.1 - 2.9e-24 85.0 0.1 4.8e-24 84.3 0.1 1.4 1 0 0 1 1 1 1 Fibronectin type III-like domain Orn_Arg_deC_N PF02784.16 CCF45957.1 - 0.12 11.8 0.1 0.18 11.1 0.1 1.2 1 0 0 1 1 1 0 Pyridoxal-dependent decarboxylase, pyridoxal binding domain HAD PF12710.7 CCF45958.1 - 8.2e-24 85.0 0.0 1.1e-23 84.6 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.12 CCF45958.1 - 0.002 17.6 0.0 0.0074 15.7 0.0 1.7 1 1 0 1 1 1 1 Putative Phosphatase UMPH-1 PF05822.12 CCF45958.1 - 0.03 13.9 0.0 0.074 12.5 0.0 1.6 1 0 0 1 1 1 0 Pyrimidine 5'-nucleotidase (UMPH-1) Hydrolase PF00702.26 CCF45958.1 - 0.044 14.1 0.1 0.12 12.6 0.1 1.9 2 1 0 2 2 2 0 haloacid dehalogenase-like hydrolase Vps5 PF09325.10 CCF45961.1 - 4.4e-88 294.8 7.7 7.4e-88 294.1 7.7 1.3 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.24 CCF45961.1 - 1.6e-25 89.3 0.2 3.3e-25 88.3 0.0 1.6 2 0 0 2 2 2 1 PX domain BAR_3 PF16746.5 CCF45961.1 - 0.0012 18.7 6.9 0.006 16.3 3.0 2.5 1 1 1 2 2 2 1 BAR domain of APPL family BAR_3_WASP_bdg PF10456.9 CCF45961.1 - 0.0032 17.0 1.0 0.032 13.7 0.8 2.2 1 1 0 1 1 1 1 WASP-binding domain of Sorting nexin protein BAR_2 PF10455.9 CCF45961.1 - 0.0035 16.5 2.4 0.0053 15.9 2.4 1.3 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking DUF713 PF05218.14 CCF45961.1 - 0.11 12.2 6.0 0.088 12.5 0.8 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF713) BAR PF03114.18 CCF45961.1 - 0.23 11.1 9.5 0.48 10.0 9.5 1.5 1 1 0 1 1 1 0 BAR domain DUF3450 PF11932.8 CCF45961.1 - 0.81 8.9 8.7 0.097 12.0 4.4 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) FAD_binding_3 PF01494.19 CCF45962.1 - 9e-19 67.9 0.0 1.1e-09 38.1 0.0 2.4 2 1 0 2 2 2 2 FAD binding domain Pyr_redox_3 PF13738.6 CCF45962.1 - 4.6e-05 22.8 0.0 6.8e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCF45962.1 - 8.5e-05 22.7 0.0 0.00017 21.7 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 CCF45962.1 - 0.00068 18.9 0.0 0.0011 18.2 0.0 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.14 CCF45962.1 - 0.00075 18.8 0.0 0.0011 18.2 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase SE PF08491.10 CCF45962.1 - 0.0011 18.1 0.0 0.0028 16.8 0.0 1.6 1 1 0 1 1 1 1 Squalene epoxidase TrkA_N PF02254.18 CCF45962.1 - 0.03 14.6 0.0 0.053 13.8 0.0 1.4 1 0 0 1 1 1 0 TrkA-N domain DAO PF01266.24 CCF45962.1 - 0.03 13.9 0.0 0.64 9.5 0.0 2.2 1 1 1 2 2 2 0 FAD dependent oxidoreductase HI0933_like PF03486.14 CCF45962.1 - 0.18 10.4 0.0 0.85 8.2 0.0 1.8 2 0 0 2 2 2 0 HI0933-like protein NAD_Gly3P_dh_N PF01210.23 CCF45962.1 - 0.2 11.6 0.0 0.51 10.3 0.0 1.7 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Fungal_trans PF04082.18 CCF45963.1 - 5.7e-13 48.5 0.0 1.1e-12 47.6 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF45963.1 - 0.23 11.6 5.1 0.47 10.6 5.1 1.5 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Abhydrolase_9_N PF15420.6 CCF45964.1 - 0.19 11.7 9.0 0.29 11.1 9.0 1.4 1 0 0 1 1 1 0 Alpha/beta-hydrolase family N-terminus Polysacc_synt PF01943.17 CCF45964.1 - 0.43 9.9 13.0 1 8.7 13.0 1.5 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein DUF3377 PF11857.8 CCF45964.1 - 1.2 9.1 7.5 0.097 12.6 1.8 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3377) FA_desaturase PF00487.24 CCF45964.1 - 4.5 7.0 7.6 21 4.8 7.7 1.9 1 1 0 1 1 1 0 Fatty acid desaturase UPF0182 PF03699.13 CCF45964.1 - 8.7 4.3 8.7 11 4.0 8.7 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0182) Pep3_Vps18 PF05131.14 CCF45967.1 - 4.2e-49 166.2 0.0 6.8e-49 165.5 0.0 1.3 1 0 0 1 1 1 1 Pep3/Vps18/deep orange family DAO PF01266.24 CCF45969.1 - 2e-07 30.9 1.1 2.1e-05 24.3 0.2 2.5 1 1 2 3 3 3 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 CCF45969.1 - 4.1e-05 23.0 0.0 5.9e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain NAD_binding_9 PF13454.6 CCF45969.1 - 4.9e-05 23.4 0.2 0.00017 21.6 0.2 1.8 1 1 0 1 1 1 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 CCF45969.1 - 0.00014 21.3 0.2 0.0003 20.1 0.2 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCF45969.1 - 0.00051 20.2 0.3 0.0017 18.5 0.1 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 CCF45969.1 - 0.012 14.7 0.0 0.018 14.1 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain GIDA PF01134.22 CCF45969.1 - 0.029 13.5 0.1 0.04 13.0 0.1 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A HI0933_like PF03486.14 CCF45969.1 - 0.063 12.0 0.1 0.094 11.4 0.1 1.2 1 0 0 1 1 1 0 HI0933-like protein Abhydrolase_1 PF00561.20 CCF45971.1 - 9.2e-23 81.2 0.1 5.9e-22 78.5 0.1 1.9 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCF45971.1 - 7.3e-17 62.7 8.1 1.6e-16 61.6 8.1 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCF45971.1 - 2.7e-10 39.9 0.0 3.7e-09 36.2 0.0 2.0 2 0 0 2 2 2 1 Serine aminopeptidase, S33 AXE1 PF05448.12 CCF45971.1 - 0.096 11.3 0.0 0.16 10.7 0.0 1.2 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) p450 PF00067.22 CCF45972.1 - 7.3e-47 160.2 0.0 1e-46 159.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 GMC_oxred_N PF00732.19 CCF45973.1 - 7.2e-56 189.7 0.0 9.1e-56 189.4 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCF45973.1 - 8e-33 114.0 0.0 2.6e-32 112.3 0.1 1.9 2 0 0 2 2 2 1 GMC oxidoreductase Pyr_redox_2 PF07992.14 CCF45973.1 - 4.3e-05 22.9 0.2 0.02 14.1 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCF45973.1 - 8.3e-05 22.3 0.9 0.0015 18.2 0.2 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 CCF45973.1 - 0.00012 21.5 1.1 0.0026 17.1 0.2 2.2 2 0 0 2 2 2 1 Thi4 family NAD_binding_8 PF13450.6 CCF45973.1 - 0.00019 21.6 0.2 0.00059 20.0 0.2 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 CCF45973.1 - 0.0002 20.6 0.2 0.00038 19.6 0.2 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_binding_2 PF00890.24 CCF45973.1 - 0.0012 18.0 1.5 0.0082 15.3 0.3 2.2 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_3 PF13738.6 CCF45973.1 - 0.086 12.1 1.3 0.36 10.0 0.6 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CCF45973.1 - 0.16 11.1 0.2 0.83 8.7 0.0 1.9 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.14 CCF45973.1 - 0.2 10.3 0.3 0.81 8.3 0.1 1.9 2 0 0 2 2 2 0 HI0933-like protein RTT107_BRCT_5 PF16770.5 CCF45974.1 - 2e-34 117.5 0.0 7.4e-32 109.2 0.0 3.5 3 0 0 3 3 3 1 Regulator of Ty1 transposition protein 107 BRCT domain PTCB-BRCT PF12738.7 CCF45974.1 - 3e-30 104.0 1.8 4.3e-21 74.6 0.2 4.2 4 0 0 4 4 4 3 twin BRCT domain BRCT PF00533.26 CCF45974.1 - 7.7e-27 93.5 0.0 8.3e-11 42.1 0.0 5.6 6 0 0 6 6 6 4 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 CCF45974.1 - 2.7e-22 79.0 0.0 2.3e-05 24.7 0.0 5.7 6 0 0 6 6 6 4 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 CCF45974.1 - 1.7e-06 28.2 0.0 0.21 11.9 0.0 3.5 3 0 0 3 3 3 2 DNA ligase 3 BRCT domain ESCRT-II PF05871.12 CCF45975.1 - 1.5e-59 200.3 0.0 2.1e-59 199.8 0.0 1.2 1 0 0 1 1 1 1 ESCRT-II complex subunit GMC_oxred_C PF05199.13 CCF45976.1 - 1.9e-30 106.3 0.1 2.3e-30 106.0 0.1 1.1 1 0 0 1 1 1 1 GMC oxidoreductase Acetyltransf_1 PF00583.25 CCF45977.1 - 0.00015 22.0 0.0 0.00034 20.8 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CCF45977.1 - 0.00019 21.4 0.0 0.0042 17.0 0.0 2.0 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CCF45977.1 - 0.00054 20.3 0.0 0.00078 19.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CCF45977.1 - 0.033 14.1 0.1 0.18 11.8 0.1 1.9 1 1 0 1 1 1 0 FR47-like protein Pro_CA PF00484.19 CCF45978.1 - 5.1e-13 49.6 0.1 2.1e-12 47.6 0.1 1.8 1 1 0 1 1 1 1 Carbonic anhydrase SET PF00856.28 CCF45979.1 - 5.1e-17 62.8 2.2 1.5e-16 61.3 0.4 2.4 2 1 0 2 2 2 1 SET domain DTHCT PF08070.11 CCF45979.1 - 7.4 7.4 15.8 0.36 11.6 7.1 2.7 2 1 2 4 4 4 0 DTHCT (NUC029) region Aldedh PF00171.22 CCF45980.1 - 5.4e-09 35.1 0.2 0.00023 19.8 0.1 2.1 2 0 0 2 2 2 2 Aldehyde dehydrogenase family SEEK1 PF15357.6 CCF45980.1 - 0.084 13.0 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 Psoriasis susceptibility 1 candidate 1 ACC_epsilon PF13822.6 CCF45984.1 - 4.1 8.2 10.2 2.4 8.9 3.1 2.2 2 0 0 2 2 2 0 Acyl-CoA carboxylase epsilon subunit GMC_oxred_N PF00732.19 CCF45985.1 - 2.3e-11 43.6 0.0 8e-06 25.4 0.0 3.0 2 1 0 2 2 2 2 GMC oxidoreductase NAD_binding_8 PF13450.6 CCF45985.1 - 7.5e-05 22.9 1.5 0.00016 21.8 0.7 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 CCF45985.1 - 0.00063 18.9 0.1 0.00088 18.5 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.12 CCF45985.1 - 0.017 14.2 0.0 0.026 13.6 0.0 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein Pyr_redox_2 PF07992.14 CCF45985.1 - 0.032 13.5 0.0 0.046 12.9 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 CCF45985.1 - 0.046 13.4 0.2 0.081 12.6 0.2 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA HI0933_like PF03486.14 CCF45985.1 - 0.22 10.2 0.7 0.3 9.8 0.7 1.1 1 0 0 1 1 1 0 HI0933-like protein Pec_lyase_C PF00544.19 CCF45986.1 - 3.9e-20 72.3 5.2 2e-18 66.7 5.2 2.2 1 1 0 1 1 1 1 Pectate lyase CBM_1 PF00734.18 CCF45986.1 - 4.1e-13 49.0 14.2 4.1e-13 49.0 14.2 2.3 2 0 0 2 2 2 1 Fungal cellulose binding domain Beta_helix PF13229.6 CCF45986.1 - 4e-10 39.8 15.2 1.7e-07 31.2 4.7 1.8 1 1 1 2 2 2 2 Right handed beta helix region CT47 PF15623.6 CCF45986.1 - 0.023 14.6 8.5 0.035 13.9 8.5 1.2 1 0 0 1 1 1 0 Cancer/testis gene family 47 ADH_zinc_N PF00107.26 CCF45989.1 - 1.5e-07 31.4 0.1 2.5e-07 30.8 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCF45989.1 - 2.3e-06 27.4 0.0 6.7e-06 26.0 0.0 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Fmp27 PF10344.9 CCF45994.1 - 5.1e-234 779.3 0.9 8.1e-234 778.6 0.0 1.8 2 0 0 2 2 2 1 Mitochondrial protein from FMP27 Apt1 PF10351.9 CCF45994.1 - 2.1e-199 663.4 1.4 2.1e-199 663.4 1.4 3.2 4 1 0 4 4 4 1 Golgi-body localisation protein domain Fmp27_WPPW PF10359.9 CCF45994.1 - 3.7e-181 603.2 1.3 5.5e-181 602.6 0.0 2.0 2 0 0 2 2 2 1 RNA pol II promoter Fmp27 protein domain Fmp27_GFWDK PF10347.9 CCF45994.1 - 3.8e-56 189.5 0.0 7.5e-56 188.6 0.0 1.5 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain DUF2405 PF10293.9 CCF45994.1 - 8.1e-56 188.2 0.1 2e-55 186.9 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF2405) Fmp27_SW PF10305.9 CCF45994.1 - 3.2e-33 114.5 0.0 2e-32 111.9 0.0 2.6 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain DUF3016 PF11454.8 CCF45994.1 - 0.00013 21.8 0.0 0.82 9.4 0.0 2.8 2 0 0 2 2 2 2 Protein of unknown function (DUF3016) RRM_1 PF00076.22 CCF45996.1 - 2.9e-10 39.8 0.0 4.9e-10 39.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Tom5 PF10642.9 CCF45996.1 - 0.19 11.8 0.1 1.3 9.1 0.0 2.0 2 0 0 2 2 2 0 Mitochondrial import receptor subunit or translocase Forkhead PF00250.18 CCF45997.1 - 4.6e-16 58.8 0.1 1.1e-15 57.6 0.1 1.6 1 0 0 1 1 1 1 Forkhead domain DUF4249 PF14054.6 CCF45997.1 - 0.17 11.4 2.6 0.15 11.7 1.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4249) Macoilin PF09726.9 CCF45997.1 - 1.7 7.1 6.0 2.3 6.7 6.0 1.1 1 0 0 1 1 1 0 Macoilin family MFS_1 PF07690.16 CCF45998.1 - 2.1e-34 119.0 24.4 2.4e-34 118.8 24.4 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF45998.1 - 6.9e-14 51.5 10.0 9.1e-14 51.2 10.0 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter AAA_13 PF13166.6 CCF45999.1 - 0.00029 19.7 1.7 0.00033 19.5 1.7 1.1 1 0 0 1 1 1 1 AAA domain Uso1_p115_C PF04871.13 CCF45999.1 - 0.00039 20.8 10.1 0.00093 19.6 1.2 2.4 1 1 1 2 2 2 1 Uso1 / p115 like vesicle tethering protein, C terminal region DUF812 PF05667.11 CCF45999.1 - 0.0013 17.7 6.5 0.0013 17.7 6.5 1.9 2 1 1 3 3 3 1 Protein of unknown function (DUF812) YscO PF07321.12 CCF45999.1 - 0.0052 16.8 12.5 0.011 15.7 12.5 1.6 1 1 0 1 1 1 1 Type III secretion protein YscO EzrA PF06160.12 CCF45999.1 - 0.01 14.1 7.3 0.015 13.5 0.7 2.1 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA DUF4407 PF14362.6 CCF45999.1 - 0.013 14.9 6.0 0.06 12.7 1.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Golgin_A5 PF09787.9 CCF45999.1 - 0.016 14.7 10.4 0.028 13.9 10.3 1.6 1 1 0 1 1 1 0 Golgin subfamily A member 5 SidE PF12252.8 CCF45999.1 - 0.017 12.7 4.0 0.019 12.5 4.0 1.0 1 0 0 1 1 1 0 Dot/Icm substrate protein FUSC PF04632.12 CCF45999.1 - 0.02 13.5 4.6 0.026 13.1 4.6 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family MAD PF05557.13 CCF45999.1 - 0.031 12.7 12.3 0.96 7.7 7.1 2.5 2 1 1 3 3 3 0 Mitotic checkpoint protein Jnk-SapK_ap_N PF09744.9 CCF45999.1 - 0.033 14.4 10.7 0.26 11.5 0.6 2.2 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 NPV_P10 PF05531.12 CCF45999.1 - 0.036 14.5 2.0 0.41 11.2 0.9 2.5 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Fez1 PF06818.15 CCF45999.1 - 0.038 14.5 13.0 0.019 15.4 10.2 1.7 2 0 0 2 2 2 0 Fez1 DUF16 PF01519.16 CCF45999.1 - 0.04 14.4 4.6 0.31 11.5 0.3 2.4 1 1 1 2 2 2 0 Protein of unknown function DUF16 HemX PF04375.14 CCF45999.1 - 0.041 13.2 3.0 0.062 12.6 0.5 1.9 1 1 1 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase TRF PF08558.10 CCF45999.1 - 0.047 13.3 0.4 0.06 12.9 0.4 1.2 1 0 0 1 1 1 0 Telomere repeat binding factor (TRF) Spc7 PF08317.11 CCF45999.1 - 0.048 12.5 11.2 0.15 10.9 6.0 2.0 1 1 1 2 2 2 0 Spc7 kinetochore protein CENP-F_leu_zip PF10473.9 CCF45999.1 - 0.065 13.3 14.4 1.3 9.1 1.5 2.5 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF241 PF03087.14 CCF45999.1 - 0.085 12.7 6.9 0.13 12.1 4.9 2.3 2 1 0 2 2 2 0 Arabidopsis protein of unknown function EMP24_GP25L PF01105.24 CCF45999.1 - 0.089 12.7 0.8 0.15 12.0 0.8 1.4 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD TPR_MLP1_2 PF07926.12 CCF45999.1 - 0.093 12.8 15.5 0.14 12.3 0.9 2.7 2 1 1 3 3 2 0 TPR/MLP1/MLP2-like protein Csm1_N PF18504.1 CCF45999.1 - 0.093 13.1 11.6 2.4 8.6 2.5 3.9 2 1 2 4 4 4 0 Csm1 N-terminal domain DUF745 PF05335.13 CCF45999.1 - 0.097 12.4 5.3 0.096 12.4 1.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF745) DUF3584 PF12128.8 CCF45999.1 - 0.11 10.0 10.5 0.2 9.2 10.4 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) DUF3450 PF11932.8 CCF45999.1 - 0.14 11.5 6.7 0.22 10.8 6.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) HrpB7 PF09486.10 CCF45999.1 - 0.15 12.4 13.9 2.1 8.7 12.6 2.5 2 1 0 2 2 1 0 Bacterial type III secretion protein (HrpB7) DUF948 PF06103.11 CCF45999.1 - 0.16 12.3 1.6 0.61 10.4 1.6 2.1 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Fzo_mitofusin PF04799.13 CCF45999.1 - 0.16 11.5 4.3 0.19 11.3 1.8 2.3 2 1 0 2 2 2 0 fzo-like conserved region Laminin_II PF06009.12 CCF45999.1 - 0.2 11.7 3.9 0.52 10.3 3.0 1.9 1 1 1 2 2 2 0 Laminin Domain II V_ATPase_I PF01496.19 CCF45999.1 - 0.21 9.5 2.5 0.21 9.5 2.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Prominin PF05478.11 CCF45999.1 - 0.22 9.4 0.1 0.24 9.3 0.1 1.1 1 0 0 1 1 1 0 Prominin BLOC1_2 PF10046.9 CCF45999.1 - 0.26 11.6 8.1 0.7 10.2 5.3 2.8 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Fmp27_WPPW PF10359.9 CCF45999.1 - 0.3 9.9 5.9 0.77 8.5 4.0 2.0 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain CENP-H PF05837.12 CCF45999.1 - 0.3 11.5 8.6 0.29 11.5 3.7 2.6 2 1 1 3 3 3 0 Centromere protein H (CENP-H) DUF1664 PF07889.12 CCF45999.1 - 0.31 11.1 5.9 0.15 12.1 2.9 1.9 2 1 1 3 3 2 0 Protein of unknown function (DUF1664) NIT PF08376.10 CCF45999.1 - 0.42 11.1 8.1 0.17 12.3 2.8 2.0 1 1 0 2 2 2 0 Nitrate and nitrite sensing TMF_DNA_bd PF12329.8 CCF45999.1 - 0.48 10.4 15.3 0.52 10.3 1.7 3.7 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding Seryl_tRNA_N PF02403.22 CCF45999.1 - 0.54 10.5 8.5 2.5 8.4 0.8 3.1 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Atg14 PF10186.9 CCF45999.1 - 0.61 9.1 5.9 1.4 7.9 3.4 2.0 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 HIP1_clath_bdg PF16515.5 CCF45999.1 - 0.84 10.3 13.7 2 9.1 3.6 3.2 2 1 1 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DivIC PF04977.15 CCF45999.1 - 1.2 8.9 10.4 4.5 7.1 0.5 4.0 2 1 2 4 4 4 0 Septum formation initiator BST2 PF16716.5 CCF45999.1 - 1.4 9.5 7.0 1.6 9.4 0.9 3.2 2 1 2 4 4 3 0 Bone marrow stromal antigen 2 APG6_N PF17675.1 CCF45999.1 - 1.4 9.4 17.4 2.2 8.8 6.8 2.8 2 1 1 3 3 3 0 Apg6 coiled-coil region Fib_alpha PF08702.10 CCF45999.1 - 1.9 8.7 5.5 3.7 7.7 0.5 3.0 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family FlgN PF05130.12 CCF45999.1 - 1.9 9.0 11.7 12 6.4 7.4 2.7 1 1 2 3 3 3 0 FlgN protein DUF2203 PF09969.9 CCF45999.1 - 2.4 8.9 8.0 10 6.8 2.3 2.8 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) PKcGMP_CC PF16808.5 CCF45999.1 - 2.8 7.9 12.0 3.5 7.5 0.6 4.3 3 1 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Tup_N PF08581.10 CCF45999.1 - 3.1 8.1 10.8 0.45 10.8 1.0 3.3 2 1 1 3 3 3 0 Tup N-terminal DHR10 PF18595.1 CCF45999.1 - 5 7.2 19.5 1 9.5 10.2 3.0 2 1 2 4 4 4 0 Designed helical repeat protein 10 domain GAS PF13851.6 CCF45999.1 - 5.7 6.2 11.5 0.83 9.0 5.4 2.3 2 1 1 3 3 2 0 Growth-arrest specific micro-tubule binding DUF1192 PF06698.11 CCF45999.1 - 5.8 7.1 13.4 1.1 9.4 3.6 3.6 2 1 1 3 3 3 0 Protein of unknown function (DUF1192) TMEM214 PF10151.9 CCF46001.1 - 0.12 10.8 0.5 0.21 10.0 0.5 1.3 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator Mito_carr PF00153.27 CCF46002.1 - 2.4e-46 155.6 1.5 8.6e-19 67.3 0.3 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 CCF46002.1 - 0.063 12.4 1.2 0.23 10.6 0.2 2.1 2 1 0 2 2 2 0 Gammaproteobacterial serine protease HisKA_4TM PF16926.5 CCF46002.1 - 0.066 12.8 0.8 0.17 11.4 0.4 1.9 1 1 1 2 2 2 0 Archaeal 4TM region of histidine kinase Sugar_tr PF00083.24 CCF46004.1 - 7.2e-86 288.8 15.0 8.2e-86 288.6 15.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF46004.1 - 1.8e-31 109.4 56.8 1.7e-28 99.6 32.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 CCF46004.1 - 1.8e-06 26.7 2.7 5.9e-06 25.0 0.5 2.1 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) MFS_2 PF13347.6 CCF46004.1 - 0.00055 18.6 2.0 0.00055 18.6 2.0 2.9 4 0 0 4 4 4 2 MFS/sugar transport protein OATP PF03137.20 CCF46004.1 - 4 5.6 9.0 0.41 8.9 0.4 2.8 1 1 2 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family ThiS PF02597.20 CCF46006.1 - 7.3e-08 32.9 0.0 8.8e-08 32.7 0.0 1.1 1 0 0 1 1 1 1 ThiS family Ribosomal_S28e PF01200.18 CCF46007.1 - 1.2e-31 108.5 1.9 1.3e-31 108.4 1.9 1.0 1 0 0 1 1 1 1 Ribosomal protein S28e Dynamitin PF04912.14 CCF46008.1 - 1.5e-08 34.5 0.6 1.6e-08 34.3 0.6 1.1 1 0 0 1 1 1 1 Dynamitin FH2 PF02181.23 CCF46008.1 - 0.047 12.8 0.1 0.049 12.8 0.1 1.0 1 0 0 1 1 1 0 Formin Homology 2 Domain TPR_MLP1_2 PF07926.12 CCF46008.1 - 0.081 13.0 0.2 0.081 13.0 0.2 1.0 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein MerR-DNA-bind PF09278.11 CCF46008.1 - 0.09 13.3 0.0 0.12 12.9 0.0 1.3 1 1 0 1 1 1 0 MerR, DNA binding Dynein_heavy PF03028.15 CCF46008.1 - 0.1 12.7 0.1 0.11 12.6 0.1 1.0 1 0 0 1 1 1 0 Dynein heavy chain region D6 P-loop domain Methyltransf_33 PF10017.9 CCF46010.1 - 1.3e-38 132.9 0.0 1.6e-36 126.0 0.0 2.1 1 1 0 1 1 1 1 Histidine-specific methyltransferase, SAM-dependent Snf7 PF03357.21 CCF46013.1 - 8.6e-34 116.6 21.6 1.1e-33 116.3 21.6 1.0 1 0 0 1 1 1 1 Snf7 CaMBD PF02888.16 CCF46013.1 - 0.01 16.0 1.5 0.01 16.0 1.5 2.3 3 0 0 3 3 3 1 Calmodulin binding domain GCN5L1 PF06320.13 CCF46013.1 - 0.056 13.6 4.3 0.075 13.2 0.5 2.2 2 0 0 2 2 2 0 GCN5-like protein 1 (GCN5L1) DUF4347 PF14252.6 CCF46013.1 - 0.056 13.3 0.7 0.19 11.5 0.7 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4347) Ist1 PF03398.14 CCF46013.1 - 0.11 12.4 6.9 0.22 11.4 6.9 1.6 1 1 0 1 1 1 0 Regulator of Vps4 activity in the MVB pathway Exonuc_VII_L PF02601.15 CCF46013.1 - 0.12 12.0 4.6 0.15 11.6 4.6 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit PspA_IM30 PF04012.12 CCF46013.1 - 0.28 10.7 16.9 0.92 9.0 4.0 2.1 1 1 0 2 2 2 0 PspA/IM30 family CCAP PF11105.8 CCF46013.1 - 0.37 10.7 4.3 0.12 12.4 0.7 1.9 2 0 0 2 2 2 0 Arthropod cardioacceleratory peptide 2a YojJ PF10372.9 CCF46013.1 - 0.68 10.1 6.8 0.91 9.7 0.3 3.3 2 1 1 3 3 3 0 Bacterial membrane-spanning protein N-terminus Spc24 PF08286.11 CCF46013.1 - 3.7 7.8 7.0 6.6 7.0 7.0 1.7 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 LDB19 PF13002.7 CCF46016.1 - 2.7e-34 118.6 0.3 4.3e-34 117.9 0.3 1.2 1 0 0 1 1 1 1 Arrestin_N terminal like Arrestin_N PF00339.29 CCF46016.1 - 8.2e-06 25.9 0.0 2.5e-05 24.4 0.0 1.9 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Fungal_trans_2 PF11951.8 CCF46017.1 - 4.9e-51 173.7 0.8 9.1e-51 172.8 0.8 1.3 1 1 0 1 1 1 1 Fungal specific transcription factor domain Pam16 PF03656.13 CCF46018.1 - 1.1e-30 106.3 0.2 1.3e-30 106.0 0.2 1.0 1 0 0 1 1 1 1 Pam16 Beta_helix PF13229.6 CCF46019.1 - 4.6e-10 39.6 17.8 9.7e-10 38.5 13.9 2.5 2 1 1 3 3 3 2 Right handed beta helix region Chondroitinas_B PF14592.6 CCF46019.1 - 8.2e-07 28.2 0.1 2.5e-06 26.7 0.0 1.8 2 0 0 2 2 2 1 Chondroitinase B DUF1565 PF07602.11 CCF46019.1 - 0.0013 18.1 0.2 0.0013 18.1 0.2 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF1565) Yip1 PF04893.17 CCF46020.1 - 3.3e-05 23.7 8.1 3.3e-05 23.7 8.1 1.8 1 1 1 2 2 2 1 Yip1 domain RCC1 PF00415.18 CCF46021.1 - 6e-60 199.7 0.5 1.1e-09 38.7 0.1 7.4 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 CCF46021.1 - 3.1e-38 128.8 25.0 9.3e-09 34.9 0.5 6.6 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat ketoacyl-synt PF00109.26 CCF46022.1 - 4.2e-57 193.6 0.0 4.7e-57 193.5 0.0 1.0 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Thiolase_N PF00108.23 CCF46022.1 - 0.023 14.1 0.0 0.04 13.3 0.0 1.4 1 0 0 1 1 1 0 Thiolase, N-terminal domain ADH_N PF08240.12 CCF46024.1 - 0.00041 20.2 0.0 0.002 18.0 0.0 1.9 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_N_2 PF16884.5 CCF46024.1 - 0.048 13.6 0.0 0.079 12.9 0.0 1.3 1 0 0 1 1 1 0 N-terminal domain of oxidoreductase RNA_pol_3_Rpc31 PF11705.8 CCF46026.1 - 8.3e-43 147.2 0.1 9.1e-43 147.1 0.1 1.0 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 DUF3437 PF11919.8 CCF46027.1 - 0.088 12.7 0.7 1.8 8.5 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3437) RRM_1 PF00076.22 CCF46028.1 - 9.4e-07 28.6 0.1 1.8e-06 27.6 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DPCD PF14913.6 CCF46028.1 - 0.037 13.4 0.1 0.046 13.1 0.1 1.2 1 0 0 1 1 1 0 DPCD protein family RRM_occluded PF16842.5 CCF46028.1 - 0.13 12.1 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 Occluded RNA-recognition motif DASH_Duo1 PF08651.10 CCF46030.1 - 0.14 11.9 0.0 0.24 11.2 0.0 1.3 1 0 0 1 1 1 0 DASH complex subunit Duo1 Fungal_trans PF04082.18 CCF46031.1 - 7.3e-26 90.8 2.0 1.5e-25 89.7 2.0 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain PBP1_TM PF14812.6 CCF46031.1 - 1.1 9.7 5.2 3 8.3 5.2 1.7 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF4407 PF14362.6 CCF46031.1 - 8.6 5.6 6.0 17 4.7 6.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Ctr PF04145.15 CCF46032.1 - 6.8e-38 130.6 0.9 8.2e-38 130.3 0.9 1.1 1 0 0 1 1 1 1 Ctr copper transporter family DUF4282 PF14110.6 CCF46032.1 - 1.4 9.7 6.2 0.85 10.4 2.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4282) Ferric_reduct PF01794.19 CCF46033.1 - 3.4e-24 85.3 7.7 3.4e-24 85.3 7.7 1.9 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 CCF46033.1 - 1.8e-14 54.2 0.0 2.8e-14 53.5 0.0 1.2 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 CCF46033.1 - 9.6e-11 41.7 0.0 2.3e-10 40.5 0.0 1.6 2 0 0 2 2 2 1 FAD-binding domain NAD_binding_1 PF00175.21 CCF46033.1 - 0.0003 21.4 0.0 0.0006 20.4 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain MFMR_assoc PF16596.5 CCF46033.1 - 0.22 11.9 2.2 0.39 11.2 2.2 1.3 1 0 0 1 1 1 0 Disordered region downstream of MFMR 40S_SA_C PF16122.5 CCF46034.1 - 1.3 10.5 6.1 1.1 10.7 2.0 2.4 1 1 0 2 2 2 0 40S ribosomal protein SA C-terminus UPF0182 PF03699.13 CCF46035.1 - 8.5 4.4 5.3 11 4.0 5.3 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0182) Tannase PF07519.11 CCF46036.1 - 0.077 11.9 0.0 0.077 11.9 0.0 1.0 1 0 0 1 1 1 0 Tannase and feruloyl esterase Calreticulin PF00262.18 CCF46037.1 - 2.7e-73 247.0 0.1 3.2e-73 246.7 0.1 1.0 1 0 0 1 1 1 1 Calreticulin family DUF1911 PF08929.10 CCF46037.1 - 0.0087 16.9 0.1 0.016 16.0 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1911) LRR_6 PF13516.6 CCF46039.1 - 2.8e-15 55.0 0.7 0.00044 20.1 0.0 7.1 7 0 0 7 7 7 3 Leucine Rich repeat LRR_1 PF00560.33 CCF46039.1 - 0.0004 20.5 0.1 1.4 9.7 0.0 4.7 5 0 0 5 5 5 1 Leucine Rich Repeat LRR_4 PF12799.7 CCF46039.1 - 0.04 14.4 4.3 19 5.8 0.0 4.7 4 2 2 6 6 6 0 Leucine Rich repeats (2 copies) SUR7 PF06687.12 CCF46042.1 - 8.3e-33 113.8 10.7 1.1e-32 113.4 10.7 1.1 1 0 0 1 1 1 1 SUR7/PalI family Trp_oprn_chp PF09534.10 CCF46042.1 - 0.0032 17.3 5.3 0.0032 17.3 5.3 1.7 2 0 0 2 2 2 1 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Amastin PF07344.11 CCF46042.1 - 0.31 10.9 15.5 0.23 11.3 13.9 1.5 2 0 0 2 2 2 0 Amastin surface glycoprotein GFO_IDH_MocA PF01408.22 CCF46044.1 - 0.00059 20.7 0.5 0.0053 17.6 0.5 2.2 1 1 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold ATP_transf PF09830.9 CCF46045.1 - 6e-16 58.3 0.1 7.6e-16 58.0 0.1 1.1 1 0 0 1 1 1 1 ATP adenylyltransferase eIF-5_eIF-2B PF01873.17 CCF46047.1 - 5e-40 136.0 0.0 6.9e-40 135.6 0.0 1.2 1 0 0 1 1 1 1 Domain found in IF2B/IF5 Utp21 PF04192.12 CCF46048.1 - 4.4e-83 278.4 0.0 6.4e-83 277.8 0.0 1.2 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain WD40 PF00400.32 CCF46048.1 - 5.7e-16 58.6 22.1 8.4e-06 26.4 0.7 9.1 9 0 0 9 9 9 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF46048.1 - 3.4e-12 46.5 0.0 0.0063 16.8 0.0 6.6 3 2 4 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CCF46048.1 - 0.00011 21.0 1.2 2.8 6.5 0.0 3.5 3 0 0 3 3 3 3 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 CCF46048.1 - 0.00022 19.9 0.0 0.00044 18.9 0.0 1.4 1 0 0 1 1 1 1 Cytochrome D1 heme domain Nucleoporin_N PF08801.11 CCF46048.1 - 0.018 13.8 0.0 0.9 8.2 0.0 2.3 1 1 0 2 2 2 0 Nup133 N terminal like PALB2_WD40 PF16756.5 CCF46048.1 - 0.041 12.8 0.1 2.7 6.8 0.0 2.8 3 0 0 3 3 3 0 Partner and localizer of BRCA2 WD40 domain HPS3_N PF14761.6 CCF46048.1 - 0.067 12.7 0.0 0.17 11.4 0.0 1.6 1 0 0 1 1 1 0 Hermansky-Pudlak syndrome 3 MFS_1 PF07690.16 CCF46049.1 - 1.4e-27 96.6 27.8 2.9e-27 95.5 27.9 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_4 PF06779.14 CCF46049.1 - 2.2e-08 33.8 6.4 4.5e-08 32.8 6.4 1.4 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB YesK PF14150.6 CCF46049.1 - 0.02 15.1 5.2 2.4 8.4 0.9 3.8 3 0 0 3 3 3 0 YesK-like protein PUCC PF03209.15 CCF46049.1 - 0.055 12.5 9.8 0.034 13.1 7.1 1.9 2 0 0 2 2 2 0 PUCC protein DUF2575 PF10837.8 CCF46049.1 - 0.14 12.5 0.3 1.8 8.9 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2575) DUF485 PF04341.12 CCF46049.1 - 0.43 10.6 0.0 0.43 10.6 0.0 3.5 4 0 0 4 4 4 0 Protein of unknown function, DUF485 Fungal_trans PF04082.18 CCF46050.1 - 5e-16 58.5 0.2 8.4e-16 57.8 0.2 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain DHH PF01368.20 CCF46051.1 - 4.5e-11 42.9 1.3 6.4e-10 39.2 0.0 2.0 2 0 0 2 2 2 2 DHH family GATase PF00117.28 CCF46052.1 - 0.0011 18.8 0.0 0.0013 18.5 0.0 1.1 1 0 0 1 1 1 1 Glutamine amidotransferase class-I GATase_3 PF07685.14 CCF46052.1 - 0.15 11.6 0.0 0.21 11.2 0.0 1.2 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain Gpr1_Fun34_YaaH PF01184.19 CCF46053.1 - 3.4e-52 177.1 12.7 4.1e-52 176.8 12.7 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family S_4TM PF18159.1 CCF46053.1 - 0.041 13.2 1.0 0.13 11.6 0.5 1.8 2 0 0 2 2 2 0 SMODS-associating 4TM effector domain Cyt-b5 PF00173.28 CCF46055.1 - 2.1e-10 40.6 0.0 2.8e-10 40.2 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Toxin_22 PF08092.11 CCF46055.1 - 0.2 11.7 1.8 0.41 10.7 1.8 1.5 1 0 0 1 1 1 0 Magi peptide toxin family TPP_enzyme_C PF02775.21 CCF46057.1 - 1.1e-23 83.7 0.2 1.7e-23 83.1 0.2 1.3 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Sigma_reg_N PF13800.6 CCF46058.1 - 0.013 15.7 0.7 2.9 8.3 0.0 2.5 2 0 0 2 2 2 0 Sigma factor regulator N-terminal Pkinase PF00069.25 CCF46059.1 - 3e-07 30.1 0.0 4.9e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Dabb PF07876.12 CCF46060.1 - 5.4e-07 30.1 0.0 7.1e-07 29.8 0.0 1.2 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain Topo_Zn_Ribbon PF08272.11 CCF46060.1 - 0.22 11.2 1.8 0.51 10.0 0.0 2.5 3 1 0 3 3 3 0 Topoisomerase I zinc-ribbon-like RNase_H PF00075.24 CCF46062.1 - 8.8e-07 29.2 0.0 1.3e-06 28.6 0.0 1.2 1 0 0 1 1 1 1 RNase H Mur_ligase_M PF08245.12 CCF46063.1 - 0.0019 18.3 0.0 0.0091 16.0 0.0 1.9 1 1 0 1 1 1 1 Mur ligase middle domain Mur_ligase_C PF02875.21 CCF46063.1 - 0.021 15.0 0.0 0.045 14.0 0.0 1.5 1 0 0 1 1 1 0 Mur ligase family, glutamate ligase domain DDE_1 PF03184.19 CCF46064.1 - 3.8e-13 49.5 0.0 1.6e-12 47.5 0.0 1.8 2 0 0 2 2 2 1 DDE superfamily endonuclease Phostensin_N PF13916.6 CCF46064.1 - 0.0043 17.3 0.8 0.09 13.1 0.0 2.5 1 1 1 2 2 2 1 PP1-regulatory protein, Phostensin N-terminal DDE_3 PF13358.6 CCF46064.1 - 0.031 14.0 1.5 0.043 13.6 0.1 1.8 2 0 0 2 2 2 0 DDE superfamily endonuclease zf-CCHC_4 PF14392.6 CCF46064.1 - 0.35 10.6 1.7 0.82 9.5 1.7 1.6 1 0 0 1 1 1 0 Zinc knuckle ATP-synt_D PF01813.17 CCF46066.1 - 0.065 13.1 0.1 0.093 12.6 0.1 1.2 1 0 0 1 1 1 0 ATP synthase subunit D Phage_Coat_B PF05356.11 CCF46067.1 - 0.0035 17.2 1.6 0.012 15.5 1.6 1.9 1 0 0 1 1 1 1 Phage Coat protein B STE PF02200.16 CCF46069.1 - 2.2e-56 189.0 0.1 3.6e-56 188.3 0.1 1.4 1 0 0 1 1 1 1 STE like transcription factor zf-C2H2 PF00096.26 CCF46069.1 - 3.2e-11 43.0 10.8 3.3e-06 27.2 0.9 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CCF46069.1 - 2e-07 31.1 3.1 2e-07 31.1 3.1 3.2 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 CCF46069.1 - 3.9e-05 24.1 8.5 0.00028 21.5 0.4 3.0 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 CCF46069.1 - 9.5e-05 22.3 0.3 9.5e-05 22.3 0.3 2.9 3 0 0 3 3 3 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CCF46069.1 - 0.038 14.3 0.2 0.038 14.3 0.2 3.2 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding FYDLN_acid PF09538.10 CCF46069.1 - 0.051 14.3 2.7 0.51 11.0 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) DSBA PF01323.20 CCF46069.1 - 0.38 10.5 2.7 10 5.9 0.1 2.9 3 0 0 3 3 3 0 DSBA-like thioredoxin domain zf-C2HC_2 PF13913.6 CCF46069.1 - 1.1 9.3 3.7 3.6 7.6 0.1 2.4 2 0 0 2 2 2 0 zinc-finger of a C2HC-type HET PF06985.11 CCF46070.1 - 7.4e-13 49.1 5.9 2.1e-10 41.1 0.9 2.2 1 1 0 2 2 2 2 Heterokaryon incompatibility protein (HET) Retrotran_gag_3 PF14244.6 CCF46072.1 - 0.12 12.2 0.0 0.23 11.3 0.0 1.5 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type PMT_4TMC PF16192.5 CCF46073.1 - 5.5e-67 225.2 14.7 5.5e-67 225.2 14.7 1.6 2 0 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 CCF46073.1 - 2e-39 135.3 0.8 2.9e-39 134.8 0.8 1.1 1 0 0 1 1 1 1 MIR domain PMT PF02366.18 CCF46073.1 - 6.3e-17 62.0 4.6 6.3e-17 62.0 4.6 2.5 2 1 1 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase DUF2976 PF11190.8 CCF46073.1 - 2.8 7.8 7.9 0.091 12.6 1.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2976) Glyco_hydro_43 PF04616.14 CCF46074.1 - 9.9e-11 41.5 3.0 1.7e-10 40.7 3.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 Isochorismatase PF00857.20 CCF46075.1 - 6.5e-16 59.0 0.0 9.9e-16 58.4 0.0 1.2 1 0 0 1 1 1 1 Isochorismatase family Cyt-b5 PF00173.28 CCF46078.1 - 1.1e-13 51.0 0.0 3e-13 49.7 0.0 1.8 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain IDO PF01231.18 CCF46078.1 - 1.3e-12 47.2 0.0 1.5e-11 43.7 0.0 2.1 2 0 0 2 2 2 1 Indoleamine 2,3-dioxygenase FAD_binding_1 PF00667.20 CCF46078.1 - 8.3e-11 41.9 0.0 5e-10 39.3 0.0 2.2 2 1 0 2 2 2 1 FAD binding domain NAD_binding_1 PF00175.21 CCF46078.1 - 1.7e-08 35.0 0.0 4.8e-08 33.6 0.0 1.8 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAM181 PF15238.6 CCF46079.1 - 0.081 12.8 0.0 0.099 12.5 0.0 1.2 1 0 0 1 1 1 0 FAM181 Tannase PF07519.11 CCF46081.1 - 1.3e-25 90.3 0.3 1.6e-25 90.0 0.3 1.1 1 0 0 1 1 1 1 Tannase and feruloyl esterase Thiolase_N PF00108.23 CCF46082.1 - 2e-15 56.9 0.2 1.6e-14 53.9 0.1 2.3 2 1 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 CCF46082.1 - 1.7e-10 40.6 0.3 6.3e-10 38.8 0.0 2.0 2 0 0 2 2 2 1 Thiolase, C-terminal domain ACP_syn_III PF08545.10 CCF46082.1 - 2.6e-07 30.4 0.3 1.2e-05 25.0 0.1 2.4 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III ketoacyl-synt PF00109.26 CCF46082.1 - 1.9e-05 24.4 0.0 4e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 CCF46082.1 - 0.014 15.4 0.4 0.16 12.0 0.0 2.5 2 0 0 2 2 2 0 Beta-ketoacyl synthase, C-terminal domain SpoVAD PF07451.11 CCF46082.1 - 0.022 13.5 0.3 0.094 11.4 0.2 1.9 2 0 0 2 2 2 0 Stage V sporulation protein AD (SpoVAD) Dendrin PF15498.6 CCF46083.1 - 0.021 13.6 1.7 0.022 13.5 1.7 1.0 1 0 0 1 1 1 0 Nephrin and CD2AP-binding protein, Dendrin X8 PF07983.13 CCF46084.1 - 2.8e-22 79.2 2.9 6e-22 78.1 2.9 1.6 1 0 0 1 1 1 1 X8 domain Zn_clus PF00172.18 CCF46086.1 - 5e-10 39.3 8.5 9.2e-10 38.5 8.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 CCF46086.1 - 0.066 12.0 0.0 0.11 11.3 0.0 1.3 1 0 0 1 1 1 0 Fungal specific transcription factor domain Pex14_N PF04695.13 CCF46086.1 - 3.8 8.2 13.8 0.49 11.0 6.9 2.1 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region IF-2B PF01008.17 CCF46088.1 - 1.6e-45 155.5 0.0 4.3e-45 154.1 0.0 1.6 1 1 0 1 1 1 1 Initiation factor 2 subunit family Usp PF00582.26 CCF46088.1 - 1.3 9.5 5.3 4.1 7.9 0.0 2.5 2 0 0 2 2 2 0 Universal stress protein family IF3_C PF00707.22 CCF46089.1 - 5.2e-06 26.3 0.1 1e-05 25.4 0.1 1.4 1 0 0 1 1 1 1 Translation initiation factor IF-3, C-terminal domain mIF3 PF14877.6 CCF46089.1 - 2.5e-05 24.0 0.0 0.00071 19.3 0.1 2.1 1 1 1 2 2 2 1 Mitochondrial translation initiation factor IF3_N PF05198.16 CCF46089.1 - 0.00033 20.9 0.1 0.001 19.3 0.2 1.7 2 0 0 2 2 2 1 Translation initiation factor IF-3, N-terminal domain Orbi_VP4 PF05059.12 CCF46089.1 - 0.046 11.7 0.0 0.052 11.6 0.0 1.1 1 0 0 1 1 1 0 Orbivirus VP4 core protein Peptidase_S26 PF10502.9 CCF46090.1 - 3.4e-06 26.9 0.0 0.00016 21.5 0.0 2.5 1 1 1 2 2 2 2 Signal peptidase, peptidase S26 Peptidase_S24 PF00717.23 CCF46090.1 - 4.5e-06 26.5 0.1 7.3e-06 25.9 0.1 1.3 1 0 0 1 1 1 1 Peptidase S24-like Arm PF00514.23 CCF46091.1 - 3.1e-76 249.3 33.0 3.9e-13 49.0 0.2 11.3 11 1 0 11 11 11 9 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 CCF46091.1 - 5.3e-18 65.1 12.1 0.00014 22.3 0.2 7.9 6 2 2 8 8 8 5 HEAT-like repeat HEAT_2 PF13646.6 CCF46091.1 - 1.4e-16 60.6 11.2 0.0015 18.8 0.2 7.2 2 2 4 8 8 8 5 HEAT repeats HEAT PF02985.22 CCF46091.1 - 1.7e-15 55.8 15.0 0.11 12.9 0.2 8.8 10 0 0 10 10 9 5 HEAT repeat Arm_2 PF04826.13 CCF46091.1 - 6.4e-11 42.2 10.4 1.7e-08 34.3 2.6 2.7 2 1 1 3 3 3 2 Armadillo-like Adaptin_N PF01602.20 CCF46091.1 - 1.2e-10 40.6 11.3 2e-07 30.0 0.4 3.0 1 1 2 3 3 3 2 Adaptin N terminal region KAP PF05804.12 CCF46091.1 - 2.5e-09 35.9 0.7 5.1e-09 34.9 0.7 1.5 1 0 0 1 1 1 1 Kinesin-associated protein (KAP) V-ATPase_H_N PF03224.14 CCF46091.1 - 1.5e-08 34.3 2.5 0.00025 20.4 0.8 3.6 2 1 1 3 3 3 2 V-ATPase subunit H Cnd1 PF12717.7 CCF46091.1 - 5.6e-06 26.5 8.3 0.065 13.3 0.1 5.2 1 1 3 6 6 6 2 non-SMC mitotic condensation complex subunit 1 V-ATPase_H_C PF11698.8 CCF46091.1 - 9.4e-05 22.5 1.5 5.4 7.1 0.2 5.1 2 1 6 8 8 8 1 V-ATPase subunit H DUF5578 PF17741.1 CCF46091.1 - 0.001 18.6 7.7 1.8 7.9 0.0 5.1 2 1 3 6 6 6 2 Family of unknown function (DUF5578) DUF3361 PF11841.8 CCF46091.1 - 0.0012 18.7 10.0 1.3 8.9 0.1 4.2 3 1 0 4 4 4 2 Domain of unknown function (DUF3361) IFRD PF05004.13 CCF46091.1 - 0.0016 17.6 4.9 1.7 7.7 0.1 4.1 3 1 1 4 4 4 2 Interferon-related developmental regulator (IFRD) HEAT_PBS PF03130.16 CCF46091.1 - 0.024 15.3 8.1 41 5.3 0.3 6.9 6 0 0 6 6 6 0 PBS lyase HEAT-like repeat Vac14_Fab1_bd PF12755.7 CCF46091.1 - 0.044 14.4 0.1 2.1 9.0 0.1 3.2 2 1 2 4 4 4 0 Vacuolar 14 Fab1-binding region Atx10homo_assoc PF09759.9 CCF46091.1 - 0.048 13.7 8.9 5.3 7.1 0.1 5.0 3 2 3 6 6 6 0 Spinocerebellar ataxia type 10 protein domain UNC45-central PF11701.8 CCF46091.1 - 0.11 12.4 4.6 8.8 6.3 0.2 3.8 4 0 0 4 4 4 0 Myosin-binding striated muscle assembly central DLH PF01738.18 CCF46092.1 - 4.7e-05 23.1 0.0 5.7e-05 22.8 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family TRI5 PF06330.11 CCF46093.1 - 2.2e-15 56.4 0.0 2.6e-15 56.2 0.0 1.1 1 0 0 1 1 1 1 Trichodiene synthase (TRI5) Corona_S2 PF01601.16 CCF46094.1 - 0.17 10.3 0.7 0.24 9.9 0.7 1.1 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein PQ-loop PF04193.14 CCF46094.1 - 5.8 6.8 7.4 5.7 6.8 0.1 3.0 3 0 0 3 3 3 0 PQ loop repeat L31 PF09784.9 CCF46095.1 - 3.3e-45 152.7 0.9 3.7e-45 152.5 0.9 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L31 MPTase-PolyVal PF18818.1 CCF46095.1 - 0.13 12.3 0.0 3.6 7.7 0.0 2.0 2 0 0 2 2 2 0 Metallopeptidase superfamily domain Sedlin_N PF04628.13 CCF46096.1 - 1.3e-12 48.0 0.0 1.4e-12 47.9 0.0 1.0 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region DUF952 PF06108.12 CCF46097.1 - 2.4e-06 27.4 0.0 2.4e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF952) UCH PF00443.29 CCF46098.1 - 6.6e-24 84.8 0.0 1.2e-23 83.9 0.0 1.4 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CCF46098.1 - 0.00076 19.2 0.0 0.00094 18.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RRM_1 PF00076.22 CCF46099.1 - 4e-09 36.2 0.0 5.9e-09 35.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FAD_binding_7 PF03441.14 CCF46101.1 - 1.4e-46 158.6 0.3 2.2e-46 157.9 0.3 1.2 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 CCF46101.1 - 1.8e-21 76.8 0.0 3.2e-21 76.0 0.0 1.4 1 0 0 1 1 1 1 DNA photolyase 4HBT PF03061.22 CCF46102.1 - 2.1e-05 24.8 0.0 4.4e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Thioesterase superfamily CSTF2_hinge PF14327.6 CCF46102.1 - 0.12 12.8 0.1 0.28 11.7 0.1 1.6 1 0 0 1 1 1 0 Hinge domain of cleavage stimulation factor subunit 2 SQS_PSY PF00494.19 CCF46103.1 - 3.1e-65 220.3 0.9 4.2e-65 219.9 0.9 1.2 1 0 0 1 1 1 1 Squalene/phytoene synthase His_Phos_2 PF00328.22 CCF46104.1 - 2.1e-24 86.6 0.0 2.7e-24 86.2 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) 4HBT_2 PF13279.6 CCF46105.1 - 3.9e-07 30.6 0.0 5.5e-07 30.1 0.0 1.2 1 0 0 1 1 1 1 Thioesterase-like superfamily adh_short PF00106.25 CCF46106.1 - 7.8e-22 77.7 0.0 1.1e-21 77.2 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF46106.1 - 5.6e-17 62.1 0.0 7.5e-17 61.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF46106.1 - 1.5e-06 28.3 0.0 2.7e-06 27.4 0.0 1.4 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF46106.1 - 0.043 13.3 0.0 6.3 6.2 0.0 2.2 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CCF46106.1 - 0.086 12.7 1.0 0.23 11.4 1.0 1.8 1 1 0 1 1 1 0 NAD(P)H-binding Glyco_hydro_43 PF04616.14 CCF46108.1 - 3.5e-75 253.0 0.6 5e-75 252.5 0.6 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 GH43_C2 PF17851.1 CCF46108.1 - 2.4e-27 96.0 0.0 3.4e-27 95.5 0.0 1.2 1 0 0 1 1 1 1 Beta xylosidase C-terminal Concanavalin A-like domain MAPEG PF01124.18 CCF46109.1 - 4.2e-13 49.3 3.4 4.6e-13 49.2 3.4 1.0 1 0 0 1 1 1 1 MAPEG family TauD PF02668.16 CCF46110.1 - 3.3e-31 109.1 0.0 7.4e-31 107.9 0.0 1.5 1 1 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family RhoGAP PF00620.27 CCF46110.1 - 0.021 14.6 0.0 0.036 13.9 0.0 1.4 1 0 0 1 1 1 0 RhoGAP domain AA_permease_2 PF13520.6 CCF46111.1 - 1.2e-74 251.7 35.7 1.4e-74 251.5 35.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CCF46111.1 - 6.3e-21 74.5 34.1 8.5e-21 74.1 34.1 1.2 1 0 0 1 1 1 1 Amino acid permease DUF1229 PF06797.11 CCF46111.1 - 0.038 14.2 0.5 5 7.3 0.1 3.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1229) 2TM PF13239.6 CCF46111.1 - 0.086 13.2 0.4 0.086 13.2 0.4 3.2 3 0 0 3 3 3 0 2TM domain HTH_Tnp_Tc5 PF03221.16 CCF46112.1 - 3.8e-12 46.0 0.1 1.1e-11 44.6 0.0 1.8 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 CCF46112.1 - 4.2e-09 36.0 0.0 7.6e-09 35.2 0.0 1.4 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_23 PF13384.6 CCF46112.1 - 0.0045 16.7 0.3 0.015 15.1 0.1 2.0 2 0 0 2 2 2 1 Homeodomain-like domain CENP-B_N PF04218.13 CCF46112.1 - 0.019 14.6 0.0 0.04 13.5 0.0 1.5 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HTH_28 PF13518.6 CCF46112.1 - 0.074 13.2 0.2 0.3 11.2 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain p450 PF00067.22 CCF46113.1 - 6.4e-41 140.6 0.0 1.6e-39 135.9 0.0 2.2 2 0 0 2 2 2 2 Cytochrome P450 NAD_binding_8 PF13450.6 CCF46114.1 - 3.3e-06 27.2 0.0 4e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 CCF46114.1 - 0.00086 18.6 0.0 0.00099 18.4 0.0 1.1 1 0 0 1 1 1 1 Thi4 family NAD_binding_9 PF13454.6 CCF46114.1 - 0.042 13.8 0.0 0.044 13.8 0.0 1.2 1 0 0 1 1 1 0 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 CCF46114.1 - 0.13 11.3 0.0 0.15 11.1 0.0 1.1 1 0 0 1 1 1 0 FAD binding domain Pyr_redox_2 PF07992.14 CCF46114.1 - 0.14 11.4 0.0 0.14 11.4 0.0 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Thg1 PF04446.12 CCF46116.1 - 1.2e-25 90.0 0.0 1.6e-25 89.6 0.0 1.2 1 0 0 1 1 1 1 tRNAHis guanylyltransferase Thg1C PF14413.6 CCF46116.1 - 5.6e-23 81.4 0.3 8.9e-23 80.8 0.3 1.3 1 0 0 1 1 1 1 Thg1 C terminal domain MAP7 PF05672.11 CCF46116.1 - 0.0067 16.1 1.1 0.0098 15.6 1.1 1.1 1 0 0 1 1 1 1 MAP7 (E-MAP-115) family Cu-oxidase_3 PF07732.15 CCF46117.1 - 1.3e-17 63.9 0.0 2.5e-17 63.0 0.0 1.5 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase PF00394.22 CCF46117.1 - 0.001 19.2 0.0 0.0023 18.1 0.0 1.7 1 1 0 1 1 1 1 Multicopper oxidase IBR PF01485.21 CCF46118.1 - 7.7e-10 38.8 0.4 7.7e-10 38.8 0.4 2.6 2 1 0 2 2 2 1 IBR domain, a half RING-finger domain zf-C3HC4_3 PF13920.6 CCF46118.1 - 2 8.3 10.3 0.073 12.9 3.1 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CCF46118.1 - 2.9 8.0 14.2 3.9 7.6 6.5 2.7 2 1 0 2 2 2 0 RING-type zinc-finger zf-RING_2 PF13639.6 CCF46118.1 - 6.8 7.1 18.0 0.24 11.7 7.3 2.4 2 0 0 2 2 2 0 Ring finger domain Tnp_zf-ribbon_2 PF13842.6 CCF46118.1 - 9.8 7.1 7.4 0.71 10.7 0.5 2.5 2 0 0 2 2 2 0 DDE_Tnp_1-like zinc-ribbon U3snoRNP10 PF12397.8 CCF46119.1 - 4.9e-28 97.8 2.0 2.3e-27 95.7 0.0 3.2 3 0 0 3 3 3 1 U3 small nucleolar RNA-associated protein 10 HEAT PF02985.22 CCF46119.1 - 0.0043 17.2 2.8 0.025 14.8 0.0 3.6 3 0 0 3 3 3 1 HEAT repeat HEAT_EZ PF13513.6 CCF46119.1 - 0.017 15.7 7.9 0.24 11.9 1.3 4.7 4 1 0 4 4 4 0 HEAT-like repeat HEAT_2 PF13646.6 CCF46119.1 - 0.023 15.1 4.7 0.07 13.5 0.0 4.2 5 0 0 5 5 5 0 HEAT repeats cNMPbd_u2 PF16643.5 CCF46119.1 - 0.093 13.2 0.9 0.24 11.9 0.9 1.6 1 0 0 1 1 1 0 Unstructured region on cNMP-binding protein Lipase_GDSL_2 PF13472.6 CCF46120.1 - 2.9e-21 76.6 0.0 4e-21 76.2 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 CCF46120.1 - 5.1e-14 52.7 0.0 6e-14 52.5 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_3 PF14606.6 CCF46120.1 - 0.12 12.5 0.0 0.21 11.7 0.0 1.2 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family FAD_binding_2 PF00890.24 CCF46122.1 - 5.6e-46 157.5 0.5 6.4e-46 157.3 0.5 1.0 1 0 0 1 1 1 1 FAD binding domain Longin_2 PF18639.1 CCF46124.1 - 0.084 12.7 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 Yeast longin domain Rrp44_CSD1 PF17216.3 CCF46125.1 - 1e-28 99.9 0.1 3.9e-28 98.0 0.1 1.9 1 1 0 1 1 1 1 Rrp44-like cold shock domain OB_Dis3 PF17849.1 CCF46125.1 - 1.9e-20 72.6 0.0 4.7e-20 71.4 0.0 1.7 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) RNB PF00773.19 CCF46125.1 - 1.3e-19 70.7 0.0 2.3e-19 69.9 0.0 1.4 1 0 0 1 1 1 1 RNB domain PIN_4 PF13638.6 CCF46125.1 - 1.2e-12 48.3 0.2 2.7e-12 47.1 0.2 1.6 1 0 0 1 1 1 1 PIN domain CSD2 PF17876.1 CCF46125.1 - 4.1e-08 33.3 0.6 0.0023 18.1 0.0 3.1 2 1 1 3 3 3 2 Cold shock domain Ank_4 PF13637.6 CCF46126.1 - 7.4e-16 58.3 0.4 1.6e-07 31.7 0.1 3.0 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 CCF46126.1 - 9.4e-14 51.8 0.1 2.9e-13 50.2 0.1 1.8 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CCF46126.1 - 6.8e-10 39.0 5.8 9e-05 22.7 0.5 2.6 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 CCF46126.1 - 8.5e-09 35.5 1.2 4.9e-05 23.6 0.1 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.6 CCF46126.1 - 2.1e-08 33.7 0.2 0.00077 19.7 0.1 3.4 3 0 0 3 3 3 2 Ankyrin repeat Pkinase PF00069.25 CCF46127.1 - 2.7e-55 187.6 0.0 3.4e-55 187.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF46127.1 - 2.3e-34 118.9 0.0 3e-34 118.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF46127.1 - 1.8e-05 24.3 0.0 2.6e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like FTA2 PF13095.6 CCF46127.1 - 0.00038 20.1 0.0 0.72 9.4 0.0 2.2 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 CCF46127.1 - 0.00086 18.2 0.0 0.0012 17.7 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase TauD PF02668.16 CCF46128.1 - 7.9e-62 209.5 0.7 9.9e-62 209.1 0.7 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family AAA PF00004.29 CCF46130.1 - 1.8e-06 28.4 0.3 9.3e-06 26.1 0.3 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) HhH-GPD PF00730.25 CCF46130.1 - 0.11 12.9 0.0 0.26 11.8 0.0 1.6 1 0 0 1 1 1 0 HhH-GPD superfamily base excision DNA repair protein OTT_1508_deam PF14441.6 CCF46131.1 - 5.1e-18 64.8 0.6 1.5e-17 63.3 0.1 2.0 2 0 0 2 2 2 1 OTT_1508-like deaminase Neuregulin PF02158.15 CCF46132.1 - 0.09 12.1 0.6 0.11 11.9 0.6 1.1 1 0 0 1 1 1 0 Neuregulin intracellular region DUF4799 PF16056.5 CCF46132.1 - 0.22 10.6 3.0 0.28 10.3 3.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4799) Abhydrolase_6 PF12697.7 CCF46133.1 - 4.1e-05 24.3 0.2 0.00054 20.6 0.2 2.1 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCF46133.1 - 0.096 11.9 0.0 14 4.9 0.0 2.3 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Aldo_ket_red PF00248.21 CCF46136.1 - 1.3e-38 132.8 0.0 1.6e-38 132.6 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family zf-C2H2_4 PF13894.6 CCF46137.1 - 0.11 13.4 0.9 0.11 13.4 0.9 5.2 6 0 0 6 6 6 0 C2H2-type zinc finger FOXP-CC PF16159.5 CCF46137.1 - 5.4 7.7 14.0 0.83 10.3 0.4 3.3 3 0 0 3 3 3 0 FOXP coiled-coil domain Glyco_transf_28 PF03033.20 CCF46138.1 - 3.6e-19 69.2 0.0 7.8e-19 68.1 0.0 1.6 1 1 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain GMC_oxred_C PF05199.13 CCF46140.1 - 8.9e-27 94.4 0.0 9.8e-27 94.2 0.0 1.0 1 0 0 1 1 1 1 GMC oxidoreductase Phage_holin_3_6 PF07332.11 CCF46142.1 - 0.021 14.8 0.7 0.021 14.8 0.7 4.2 5 0 0 5 5 5 0 Putative Actinobacterial Holin-X, holin superfamily III Ribosomal_S15 PF00312.22 CCF46143.1 - 0.12 12.6 0.7 0.46 10.7 0.2 2.0 2 0 0 2 2 2 0 Ribosomal protein S15 HATPase_c PF02518.26 CCF46145.1 - 8.5e-23 81.0 0.2 1.6e-22 80.1 0.2 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase RRM_1 PF00076.22 CCF46147.1 - 2e-18 66.0 0.1 3.3e-18 65.2 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CCF46147.1 - 0.00011 21.7 0.0 0.00014 21.5 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CCF46147.1 - 0.022 14.6 0.0 0.03 14.2 0.0 1.2 1 0 0 1 1 1 0 Occluded RNA-recognition motif Frankia_peptide PF14407.6 CCF46147.1 - 0.13 12.2 0.0 1.5 8.8 0.0 2.2 2 0 0 2 2 2 0 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. DUF4523 PF15023.6 CCF46147.1 - 0.15 11.9 0.0 0.17 11.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4523) VASt PF16016.5 CCF46148.1 - 3e-38 131.6 2.3 8.8e-38 130.1 2.3 1.9 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain BAR_3 PF16746.5 CCF46148.1 - 5.6e-17 62.2 0.0 1e-16 61.4 0.0 1.3 1 0 0 1 1 1 1 BAR domain of APPL family PH PF00169.29 CCF46148.1 - 2.2e-05 24.9 0.1 5.4e-05 23.6 0.1 1.7 1 0 0 1 1 1 1 PH domain GRAM PF02893.20 CCF46148.1 - 0.009 15.9 0.0 0.02 14.8 0.0 1.5 1 0 0 1 1 1 1 GRAM domain DUF639 PF04842.12 CCF46148.1 - 0.042 13.3 0.7 0.083 12.3 0.7 1.4 1 0 0 1 1 1 0 Plant protein of unknown function (DUF639) Aldedh PF00171.22 CCF46149.1 - 9.4e-142 472.8 0.0 1.2e-141 472.5 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 CCF46149.1 - 0.099 11.7 0.0 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 Acyl-CoA reductase (LuxC) Cu-oxidase_3 PF07732.15 CCF46150.1 - 6.4e-43 145.6 2.6 1.1e-42 144.9 2.6 1.3 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 CCF46150.1 - 0.019 14.7 5.4 0.097 12.4 5.4 2.0 1 1 0 1 1 1 0 Multicopper oxidase Exo_endo_phos PF03372.23 CCF46151.1 - 0.0044 16.6 0.0 0.0066 16.0 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family U-box PF04564.15 CCF46152.1 - 0.012 15.8 0.0 0.012 15.8 0.0 1.1 1 0 0 1 1 1 0 U-box domain U3_assoc_6 PF08640.11 CCF46153.1 - 3.8e-28 97.4 0.5 4.2e-28 97.2 0.5 1.0 1 0 0 1 1 1 1 U3 small nucleolar RNA-associated protein 6 Frag1 PF10277.9 CCF46154.1 - 6.4e-14 52.0 0.1 7.3e-14 51.8 0.1 1.1 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family Phage_holin_2_4 PF16082.5 CCF46155.1 - 0.2 11.4 1.8 0.31 10.8 0.0 2.1 2 0 0 2 2 2 0 Bacteriophage holin family, superfamily II-like ABC_membrane PF00664.23 CCF46156.1 - 9.3e-49 166.5 10.1 1.3e-48 166.1 10.1 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 CCF46156.1 - 7.4e-42 143.1 0.0 9.5e-29 100.7 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 CCF46156.1 - 3.7e-11 42.9 1.6 0.00075 19.0 0.2 3.1 2 1 1 3 3 3 2 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 CCF46156.1 - 0.00055 20.1 6.4 1 9.7 0.2 4.4 3 2 0 3 3 2 2 Putative exonuclease SbcCD, C subunit AAA PF00004.29 CCF46156.1 - 0.00092 19.7 2.4 0.23 11.9 0.4 3.2 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CCF46156.1 - 0.0012 19.2 0.1 0.28 11.5 0.2 3.3 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 CCF46156.1 - 0.0024 18.1 0.1 0.092 13.0 0.0 2.9 2 1 0 2 2 2 1 AAA domain ABC_ATPase PF09818.9 CCF46156.1 - 0.0033 16.3 0.3 0.028 13.2 0.0 2.3 2 0 0 2 2 2 1 Predicted ATPase of the ABC class AAA_21 PF13304.6 CCF46156.1 - 0.011 15.6 0.1 0.3 10.8 0.0 2.3 1 1 1 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_25 PF13481.6 CCF46156.1 - 0.014 15.0 0.1 1.1 8.8 0.0 3.2 3 0 0 3 3 3 0 AAA domain RsgA_GTPase PF03193.16 CCF46156.1 - 0.017 15.1 0.0 0.051 13.5 0.0 1.7 2 0 0 2 2 2 0 RsgA GTPase AAA_15 PF13175.6 CCF46156.1 - 0.023 14.4 0.0 0.036 13.8 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain AAA_7 PF12775.7 CCF46156.1 - 0.026 14.0 0.0 0.054 13.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_30 PF13604.6 CCF46156.1 - 0.039 13.7 5.4 0.47 10.2 0.0 3.8 4 0 0 4 4 4 0 AAA domain Rad17 PF03215.15 CCF46156.1 - 0.088 12.7 0.0 0.21 11.5 0.0 1.6 1 0 0 1 1 1 0 Rad17 P-loop domain DUF2057 PF09829.9 CCF46156.1 - 0.24 11.5 4.3 7.2 6.7 0.0 2.5 3 0 0 3 3 2 0 Uncharacterized protein conserved in bacteria (DUF2057) PrgI PF12666.7 CCF46156.1 - 9.7 7.0 7.3 2.8 8.7 1.2 2.5 2 0 0 2 2 2 0 PrgI family protein Zn_clus PF00172.18 CCF46157.1 - 1.2e-08 34.9 10.3 2.1e-08 34.2 10.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_hydro_17 PF00332.18 CCF46158.1 - 1.6e-07 31.2 0.2 2.4e-07 30.7 0.2 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 17 Apt1 PF10351.9 CCF46158.1 - 8.6 5.1 5.5 12 4.6 5.5 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain UDPG_MGDP_dh PF00984.19 CCF46159.1 - 3.1e-19 68.9 0.0 7.3e-19 67.8 0.0 1.6 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_N PF03721.14 CCF46159.1 - 9.9e-17 61.1 0.0 1.8e-10 40.7 0.0 2.2 1 1 1 2 2 2 2 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_2 PF03446.15 CCF46159.1 - 1.8e-06 28.2 0.0 2.9e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase UDPG_MGDP_dh_C PF03720.15 CCF46159.1 - 0.0043 17.5 0.0 0.0082 16.6 0.0 1.4 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain TrkA_N PF02254.18 CCF46159.1 - 0.13 12.5 0.0 0.27 11.5 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain ABC_tran PF00005.27 CCF46161.1 - 2.8e-12 47.3 0.0 7.5e-12 45.9 0.0 1.6 2 0 0 2 2 2 1 ABC transporter ABC_trans_N PF14510.6 CCF46161.1 - 1.7e-11 44.6 0.1 3.1e-11 43.7 0.1 1.5 1 0 0 1 1 1 1 ABC-transporter N-terminal AAA_16 PF13191.6 CCF46161.1 - 0.01 16.2 0.0 0.067 13.6 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 CCF46161.1 - 0.053 13.8 0.0 0.094 13.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 CCF46161.1 - 0.096 12.4 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_19 PF13245.6 CCF46161.1 - 0.11 12.8 0.0 0.23 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain DnaB_C PF03796.15 CCF46161.1 - 0.21 10.9 0.0 0.3 10.4 0.0 1.2 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain Peptidase_S8 PF00082.22 CCF46165.1 - 1.1e-25 90.5 0.3 1.7e-25 89.9 0.3 1.2 1 0 0 1 1 1 1 Subtilase family Peptidase_S9 PF00326.21 CCF46167.1 - 4.7e-48 163.5 0.0 7.8e-48 162.8 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family AXE1 PF05448.12 CCF46167.1 - 0.0035 16.1 0.0 0.25 10.0 0.0 2.4 1 1 0 1 1 1 1 Acetyl xylan esterase (AXE1) Abhydrolase_1 PF00561.20 CCF46167.1 - 0.0037 16.9 1.0 0.43 10.2 1.1 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 CCF46167.1 - 0.0061 16.4 0.0 1.1 9.0 0.0 2.7 3 0 0 3 3 3 2 alpha/beta hydrolase fold PD40 PF07676.12 CCF46167.1 - 0.016 15.2 0.2 3 7.9 0.0 3.0 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Mannosidase_ig PF17786.1 CCF46168.1 - 8.3e-19 68.0 0.0 3.9e-18 65.8 0.0 2.1 2 0 0 2 2 2 1 Mannosidase Ig/CBM-like domain Glyco_hydro_2 PF00703.21 CCF46168.1 - 3.6e-10 40.5 0.0 7.6e-10 39.4 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 Ig_mannosidase PF17753.1 CCF46168.1 - 0.00078 19.2 0.0 0.0021 17.8 0.0 1.7 1 0 0 1 1 1 1 Ig-fold domain Glyco_hydro_2_C PF02836.17 CCF46168.1 - 0.00085 18.5 0.0 0.0014 17.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain MFS_1 PF07690.16 CCF46169.1 - 1.3e-28 100.0 26.0 1.6e-28 99.7 26.0 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Zn_clus PF00172.18 CCF46170.1 - 4.1e-09 36.4 9.6 6e-09 35.9 9.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CDC45 PF02724.14 CCF46170.1 - 0.051 11.9 1.6 0.049 11.9 1.6 1.0 1 0 0 1 1 1 0 CDC45-like protein SelP_N PF04592.14 CCF46170.1 - 0.8 9.1 13.5 0.026 14.0 7.4 1.6 2 0 0 2 2 2 0 Selenoprotein P, N terminal region Chorion_2 PF03964.15 CCF46170.1 - 1.3 9.9 4.8 0.6 11.0 3.0 1.4 1 1 0 1 1 1 0 Chorion family 2 Zip PF02535.22 CCF46170.1 - 3.5 6.8 4.1 3.6 6.7 4.1 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF658 PF04936.12 CCF46172.1 - 0.017 14.8 0.6 0.023 14.5 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF658) MOSC PF03473.17 CCF46173.1 - 3.7e-37 127.3 0.0 6.4e-37 126.5 0.0 1.4 1 0 0 1 1 1 1 MOSC domain MOSC_N PF03476.16 CCF46173.1 - 1.7e-23 82.7 0.0 3.2e-23 81.9 0.0 1.5 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain BET PF17035.5 CCF46174.1 - 3.4e-07 30.3 2.2 5.2e-07 29.7 0.6 2.0 2 0 0 2 2 2 1 Bromodomain extra-terminal - transcription regulation p25-alpha PF05517.12 CCF46174.1 - 0.0037 17.4 0.4 0.025 14.7 0.4 2.0 1 1 1 2 2 2 1 p25-alpha MgtE_N PF03448.17 CCF46174.1 - 0.025 15.2 0.2 0.044 14.4 0.2 1.4 1 0 0 1 1 1 0 MgtE intracellular N domain UTP15_C PF09384.10 CCF46174.1 - 0.031 14.0 0.1 0.07 12.8 0.1 1.6 1 0 0 1 1 1 0 UTP15 C terminal DUF3791 PF12668.7 CCF46174.1 - 0.046 13.8 0.0 0.17 12.0 0.0 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF3791) p450 PF00067.22 CCF46176.1 - 1.9e-32 112.6 0.0 2.5e-32 112.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 JmjN PF02375.17 CCF46176.1 - 0.13 12.3 0.1 3.8 7.5 0.0 2.6 2 0 0 2 2 2 0 jmjN domain BLM10_mid PF16507.5 CCF46176.1 - 0.21 10.2 0.0 0.35 9.5 0.0 1.2 1 0 0 1 1 1 0 Proteasome-substrate-size regulator, mid region Mpv17_PMP22 PF04117.12 CCF46178.1 - 1.2e-09 38.2 0.5 1.2e-09 38.2 0.5 2.0 2 0 0 2 2 2 1 Mpv17 / PMP22 family Methyltransf_15 PF09445.10 CCF46178.1 - 0.038 13.6 0.0 0.053 13.1 0.0 1.1 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase HATPase_c PF02518.26 CCF46179.1 - 2.6e-21 76.2 0.0 6.3e-21 75.0 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CCF46179.1 - 1.7e-17 63.6 0.7 2.8e-16 59.7 0.0 3.0 2 1 0 2 2 2 1 Response regulator receiver domain PAS_4 PF08448.10 CCF46179.1 - 3.1e-15 56.4 0.2 0.00084 19.6 0.0 4.7 3 1 0 3 3 3 3 PAS fold PAS PF00989.25 CCF46179.1 - 1.1e-12 48.0 0.0 0.0013 18.7 0.0 3.9 3 0 0 3 3 3 3 PAS fold PAS_9 PF13426.7 CCF46179.1 - 3.2e-11 43.4 0.1 0.00063 20.0 0.0 4.0 3 0 0 3 3 3 3 PAS domain PAS_3 PF08447.12 CCF46179.1 - 5e-09 36.3 0.1 0.00023 21.4 0.1 3.6 3 0 0 3 3 3 2 PAS fold HisKA PF00512.25 CCF46179.1 - 2.1e-08 34.1 0.0 1e-07 31.8 0.0 2.4 1 1 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_8 PF13188.7 CCF46179.1 - 2.5e-05 24.2 0.0 0.066 13.3 0.0 3.4 3 0 0 3 3 3 2 PAS domain GAF_2 PF13185.6 CCF46179.1 - 0.0033 17.7 0.0 0.047 14.0 0.0 2.5 2 0 0 2 2 2 1 GAF domain GAF_3 PF13492.6 CCF46179.1 - 0.0041 17.5 0.0 0.037 14.4 0.0 2.4 2 0 0 2 2 2 1 GAF domain GAF PF01590.26 CCF46179.1 - 0.029 15.0 0.0 1.2 9.7 0.0 2.8 2 0 0 2 2 2 0 GAF domain PAS_7 PF12860.7 CCF46179.1 - 0.029 14.5 0.4 0.27 11.4 0.1 2.8 2 1 0 2 2 2 0 PAS fold CFEM PF05730.11 CCF46180.1 - 3.1e-10 40.0 11.5 7.6e-10 38.7 11.5 1.7 1 1 0 1 1 1 1 CFEM domain Adeno_PV PF03910.13 CCF46180.1 - 0.39 9.4 2.0 0.48 9.1 2.0 1.1 1 0 0 1 1 1 0 Adenovirus minor core protein PV Med3 PF11593.8 CCF46180.1 - 2.2 7.4 7.0 3 6.9 7.0 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal WD40 PF00400.32 CCF46181.1 - 1.1e-21 76.7 17.9 0.00014 22.6 0.1 6.7 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF46181.1 - 6e-12 45.7 1.5 0.038 14.3 0.0 5.7 2 2 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CCF46181.1 - 8.5e-07 29.0 0.0 0.034 14.0 0.0 2.9 2 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A WD40_3 PF15911.5 CCF46181.1 - 0.0027 17.6 0.0 0.063 13.3 0.0 2.5 2 0 0 2 2 2 1 WD domain, G-beta repeat Cytochrom_D1 PF02239.16 CCF46181.1 - 0.026 13.0 0.0 3.8 5.9 0.0 3.4 2 1 2 4 4 4 0 Cytochrome D1 heme domain PD40 PF07676.12 CCF46181.1 - 0.11 12.5 0.0 45 4.1 0.1 3.5 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat ABC_tran PF00005.27 CCF46182.1 - 5.1e-22 78.9 0.0 8e-22 78.2 0.0 1.3 1 0 0 1 1 1 1 ABC transporter ABC2_membrane PF01061.24 CCF46182.1 - 1.5e-17 63.7 9.5 2.2e-17 63.2 9.5 1.3 1 0 0 1 1 1 1 ABC-2 type transporter ABC2_membrane_3 PF12698.7 CCF46182.1 - 8.3e-06 25.1 12.4 1.2e-05 24.6 12.4 1.3 1 0 0 1 1 1 1 ABC-2 family transporter protein RsgA_GTPase PF03193.16 CCF46182.1 - 0.018 15.0 0.8 0.039 13.9 0.8 1.6 1 0 0 1 1 1 0 RsgA GTPase PHTB1_C PF14728.6 CCF46183.1 - 0.037 13.1 0.2 0.041 13.0 0.2 1.1 1 0 0 1 1 1 0 PTHB1 C-terminus UPF0449 PF15136.6 CCF46183.1 - 0.052 14.0 0.7 0.056 13.9 0.7 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0449 PTR2 PF00854.21 CCF46184.1 - 3.4e-60 203.9 2.5 5.6e-60 203.2 2.5 1.3 1 1 0 1 1 1 1 POT family HlyIII PF03006.20 CCF46184.1 - 0.014 15.2 10.8 0.049 13.3 3.5 3.0 2 1 1 3 3 3 0 Haemolysin-III related RseC_MucC PF04246.12 CCF46184.1 - 0.14 12.1 3.0 1.7 8.6 0.1 3.0 3 0 0 3 3 3 0 Positive regulator of sigma(E), RseC/MucC Bax1-I PF01027.20 CCF46184.1 - 1.2 8.9 13.7 2 8.2 9.4 2.5 2 1 0 2 2 2 0 Inhibitor of apoptosis-promoting Bax1 Zn_ribbon_17 PF17120.5 CCF46185.1 - 0.096 12.3 1.4 0.26 11.0 1.4 1.7 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type Herpes_LMP1 PF05297.11 CCF46186.1 - 0.02 14.1 0.3 0.02 14.1 0.3 2.1 1 1 1 2 2 2 0 Herpesvirus latent membrane protein 1 (LMP1) Borrelia_P83 PF05262.11 CCF46188.1 - 0.043 12.3 30.9 0.05 12.1 30.9 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein PI3K_1B_p101 PF10486.9 CCF46188.1 - 0.29 8.9 5.5 0.37 8.5 5.5 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit LAP1C PF05609.12 CCF46188.1 - 0.58 9.2 18.1 0.73 8.8 18.1 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Asp-B-Hydro_N PF05279.11 CCF46188.1 - 0.89 9.6 25.6 1.2 9.2 25.6 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region BAF1_ABF1 PF04684.13 CCF46188.1 - 2.6 7.0 23.1 3.3 6.6 23.1 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Plasmodium_Vir PF05795.11 CCF46188.1 - 5.1 6.4 19.7 10 5.4 19.7 1.5 1 1 0 1 1 1 0 Plasmodium vivax Vir protein Ndc1_Nup PF09531.10 CCF46188.1 - 6.6 5.3 11.1 6.3 5.4 11.1 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup WBS_methylT PF12589.8 CCF46189.1 - 2.9e-16 60.0 6.2 5.2e-16 59.2 6.2 1.5 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_11 PF08241.12 CCF46189.1 - 7.7e-12 45.7 0.0 1.5e-11 44.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF46189.1 - 5.6e-11 43.0 0.0 1.4e-10 41.7 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF46189.1 - 1.8e-05 25.4 0.0 6.4e-05 23.6 0.0 2.0 2 1 0 2 2 2 1 Methyltransferase domain PCMT PF01135.19 CCF46189.1 - 0.00029 20.6 0.0 0.00049 19.9 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 CCF46189.1 - 0.0014 18.5 0.0 0.0022 17.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF46189.1 - 0.0023 17.8 0.0 0.0036 17.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 CCF46189.1 - 0.0048 16.2 0.0 0.11 11.7 0.0 2.1 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.18 CCF46189.1 - 0.041 13.2 0.0 0.13 11.6 0.0 1.8 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family Methyltransf_2 PF00891.18 CCF46189.1 - 0.095 12.0 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 O-methyltransferase domain Erv26 PF04148.13 CCF46190.1 - 6.6e-51 173.1 5.2 7.2e-51 172.9 5.2 1.0 1 0 0 1 1 1 1 Transmembrane adaptor Erv26 Cytochrom_C_asm PF01578.20 CCF46190.1 - 0.00033 20.5 0.2 0.00045 20.0 0.2 1.2 1 0 0 1 1 1 1 Cytochrome C assembly protein OPT PF03169.15 CCF46194.1 - 5e-145 484.6 33.6 5.5e-145 484.4 33.6 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein EIAV_GP90 PF00971.18 CCF46194.1 - 0.61 8.7 4.3 0.92 8.1 0.1 2.2 2 0 0 2 2 2 0 EIAV coat protein, gp90 FAM176 PF14851.6 CCF46195.1 - 0.12 12.0 1.4 0.27 10.9 1.4 1.5 1 0 0 1 1 1 0 FAM176 family Conotoxin PF02950.17 CCF46195.1 - 0.22 12.6 2.3 5.4 8.1 0.0 2.7 2 0 0 2 2 2 0 Conotoxin RXT2_N PF08595.11 CCF46195.1 - 3.7 7.6 6.7 97 2.9 6.4 2.3 2 0 0 2 2 2 0 RXT2-like, N-terminal TFIID-18kDa PF02269.16 CCF46197.1 - 6.1e-25 87.1 1.5 5.9e-24 83.9 0.6 2.3 2 0 0 2 2 2 1 Transcription initiation factor IID, 18kD subunit CBFD_NFYB_HMF PF00808.23 CCF46197.1 - 0.039 14.2 1.0 28 5.1 0.3 3.7 4 0 0 4 4 4 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 CCF46197.1 - 0.37 11.3 4.5 3.2 8.3 0.2 3.1 3 0 0 3 3 3 0 Transcription initiation factor TFIID subunit A Cas_CXXC_CXXC PF09706.10 CCF46198.1 - 0.23 11.7 0.0 0.34 11.2 0.0 1.2 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_CXXC_CXXC) Peptidase_S10 PF00450.22 CCF46199.1 - 2.7e-52 178.6 0.0 3.9e-52 178.1 0.0 1.2 1 0 0 1 1 1 1 Serine carboxypeptidase HAGH_C PF16123.5 CCF46200.1 - 2.9e-24 85.4 1.6 5e-24 84.6 1.6 1.4 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.27 CCF46200.1 - 6.5e-19 68.7 1.1 9.2e-17 61.7 1.1 2.1 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CCF46200.1 - 0.00056 19.5 0.3 0.011 15.3 0.3 2.2 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Peripla_BP_4 PF13407.6 CCF46200.1 - 0.011 15.3 1.3 0.064 12.8 0.3 2.0 2 0 0 2 2 2 0 Periplasmic binding protein domain Chitin_bind_1 PF00187.19 CCF46201.1 - 1.1e-16 61.0 40.6 2.2e-09 37.6 17.3 2.7 3 0 0 3 3 3 2 Chitin recognition protein Amidohydro_1 PF01979.20 CCF46202.1 - 1.2e-13 51.1 0.0 1.6e-13 50.7 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 CCF46202.1 - 5.6e-10 39.3 0.0 7.2e-10 38.9 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Patatin PF01734.22 CCF46203.1 - 5.3e-17 62.7 0.2 6.1e-17 62.5 0.2 1.0 1 0 0 1 1 1 1 Patatin-like phospholipase MutS_III PF05192.18 CCF46204.1 - 5.9e-35 121.2 0.0 1.1e-34 120.3 0.0 1.5 1 0 0 1 1 1 1 MutS domain III MutS_II PF05188.17 CCF46204.1 - 1.2e-14 54.7 0.5 7.2e-14 52.2 0.0 2.5 2 1 0 2 2 2 1 MutS domain II MutS_IV PF05190.18 CCF46204.1 - 2.5e-14 53.4 0.9 6.8e-14 52.0 0.9 1.8 1 0 0 1 1 1 1 MutS family domain IV MutS_I PF01624.20 CCF46204.1 - 7.4e-12 45.5 0.0 1.4e-11 44.6 0.0 1.5 1 0 0 1 1 1 1 MutS domain I DUF3461 PF11944.8 CCF46204.1 - 0.15 12.2 1.4 0.42 10.8 1.4 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3461) DUF3915 PF13054.6 CCF46205.1 - 0.53 10.3 4.5 0.8 9.7 4.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) GDP_Man_Dehyd PF16363.5 CCF46206.1 - 1.7e-69 234.7 0.0 2e-69 234.5 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 CCF46206.1 - 6.6e-57 192.7 0.0 8.2e-57 192.4 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 CCF46206.1 - 2.7e-24 85.8 0.0 3.6e-23 82.1 0.0 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 CCF46206.1 - 1.3e-19 70.3 0.0 1.7e-19 69.9 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 CCF46206.1 - 1.1e-18 67.3 0.1 2e-17 63.2 0.1 2.1 1 1 0 1 1 1 1 Male sterility protein RmlD_sub_bind PF04321.17 CCF46206.1 - 3.7e-17 62.4 0.0 4.6e-17 62.0 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 CCF46206.1 - 1.1e-07 31.9 0.0 2.1e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding adh_short PF00106.25 CCF46206.1 - 0.1 12.1 0.0 1.6 8.1 0.1 2.3 2 0 0 2 2 2 0 short chain dehydrogenase WD40 PF00400.32 CCF46207.1 - 1e-09 38.8 18.1 0.015 16.1 0.4 7.7 8 0 0 8 8 8 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF46207.1 - 8.3e-05 22.8 0.1 8.6 6.7 0.0 5.3 4 2 2 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain p450 PF00067.22 CCF46208.1 - 2.1e-66 224.6 0.0 2.8e-66 224.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 ParA PF10609.9 CCF46209.1 - 9.4e-82 274.1 0.1 1.2e-81 273.8 0.1 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 CCF46209.1 - 5.6e-07 29.7 0.0 6.9e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 CCF46209.1 - 0.00021 21.2 0.1 0.0027 17.7 0.1 2.1 1 1 0 1 1 1 1 AAA domain ArsA_ATPase PF02374.15 CCF46209.1 - 0.00029 20.1 0.6 0.0022 17.2 0.6 2.0 1 1 0 2 2 2 1 Anion-transporting ATPase MipZ PF09140.11 CCF46209.1 - 0.0039 16.5 0.0 0.0078 15.5 0.0 1.5 1 1 0 1 1 1 1 ATPase MipZ AAA_25 PF13481.6 CCF46209.1 - 0.0041 16.7 0.1 0.007 16.0 0.1 1.3 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CCF46209.1 - 0.0074 16.0 0.0 0.012 15.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 CCF46209.1 - 0.013 15.4 0.0 0.028 14.4 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase TsaE PF02367.17 CCF46209.1 - 0.015 15.3 0.0 0.027 14.4 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_16 PF13191.6 CCF46209.1 - 0.032 14.6 0.0 0.068 13.5 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain CLP1_P PF16575.5 CCF46209.1 - 0.052 13.4 0.0 0.078 12.8 0.0 1.2 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop VirE PF05272.11 CCF46209.1 - 0.063 13.0 0.0 0.44 10.2 0.0 2.0 2 0 0 2 2 2 0 Virulence-associated protein E RNA_helicase PF00910.22 CCF46209.1 - 0.079 13.4 0.0 0.12 12.7 0.0 1.3 1 0 0 1 1 1 0 RNA helicase Zn_Tnp_IS1595 PF12760.7 CCF46209.1 - 0.085 12.9 0.0 0.26 11.3 0.0 1.8 1 0 0 1 1 1 0 Transposase zinc-ribbon domain CBP_BcsQ PF06564.12 CCF46209.1 - 0.18 11.3 0.0 2.1 7.8 0.0 2.0 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsQ Rad17 PF03215.15 CCF46209.1 - 0.19 11.6 0.0 0.33 10.8 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_5 PF07728.14 CCF46209.1 - 0.21 11.6 0.0 0.46 10.5 0.0 1.6 2 0 0 2 2 1 0 AAA domain (dynein-related subfamily) Ras PF00071.22 CCF46209.1 - 0.23 11.0 0.0 0.33 10.5 0.0 1.2 1 0 0 1 1 1 0 Ras family HEAT_2 PF13646.6 CCF46210.1 - 8.8e-26 90.1 7.0 8.3e-13 48.5 0.1 3.8 2 2 2 4 4 4 2 HEAT repeats HEAT_PBS PF03130.16 CCF46210.1 - 2.7e-17 61.6 5.6 0.0059 17.2 0.0 6.6 6 0 0 6 6 6 4 PBS lyase HEAT-like repeat HEAT PF02985.22 CCF46210.1 - 8.1e-09 35.0 2.6 0.65 10.4 0.1 5.6 6 0 0 6 6 6 3 HEAT repeat HEAT_EZ PF13513.6 CCF46210.1 - 0.0002 21.8 9.0 0.56 10.8 0.0 5.2 4 1 2 6 6 6 2 HEAT-like repeat Vitellogenin_N PF01347.22 CCF46210.1 - 0.052 12.0 0.0 17 3.6 0.0 2.9 3 0 0 3 3 3 0 Lipoprotein amino terminal region TFIIS_C PF01096.18 CCF46211.1 - 2.9e-15 55.8 1.7 2.9e-15 55.8 1.7 3.0 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 CCF46211.1 - 8.7e-05 22.3 3.3 8.7e-05 22.3 3.3 2.7 3 0 0 3 3 3 1 RNA polymerases M/15 Kd subunit UCH_1 PF13423.6 CCF46211.1 - 0.0061 16.2 2.5 0.0066 16.1 2.5 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Lar_restr_allev PF14354.6 CCF46211.1 - 0.017 15.5 11.1 0.19 12.1 0.5 3.2 2 1 1 3 3 3 0 Restriction alleviation protein Lar zinc_ribbon_9 PF14369.6 CCF46211.1 - 0.025 14.8 6.7 0.23 11.8 0.5 2.6 3 0 0 3 3 3 0 zinc-ribbon Zn-ribbon_8 PF09723.10 CCF46211.1 - 0.034 14.2 6.0 0.9 9.7 0.1 2.6 2 0 0 2 2 2 0 Zinc ribbon domain DZR PF12773.7 CCF46211.1 - 0.099 12.7 9.3 8.8 6.4 9.3 2.4 1 1 0 1 1 1 0 Double zinc ribbon zf-ISL3 PF14690.6 CCF46211.1 - 0.48 11.1 5.6 6.6 7.5 0.1 3.0 3 0 0 3 3 3 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 zf-RING_7 PF02591.15 CCF46211.1 - 0.71 10.1 11.8 8.5 6.7 0.2 3.8 4 1 0 4 4 4 0 C4-type zinc ribbon domain zf-IS66 PF13005.7 CCF46211.1 - 0.93 9.9 11.7 6.3 7.3 0.1 3.5 4 0 0 4 4 4 0 zinc-finger binding domain of transposase IS66 DUF1922 PF09082.10 CCF46211.1 - 1.7 9.0 7.1 1.3 9.4 0.1 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF1922) NOB1_Zn_bind PF08772.11 CCF46211.1 - 1.8 8.8 11.5 22 5.3 5.5 3.0 1 1 0 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like zinc_ribbon_2 PF13240.6 CCF46211.1 - 2.8 7.8 17.5 2.6 7.9 1.1 3.7 4 0 0 4 4 4 0 zinc-ribbon domain OrfB_Zn_ribbon PF07282.11 CCF46211.1 - 4.6 7.3 12.0 1.3 9.0 1.2 2.9 2 2 1 3 3 3 0 Putative transposase DNA-binding domain Nudix_N_2 PF14803.6 CCF46211.1 - 9.7 6.2 11.2 5.1 7.1 0.2 2.9 2 1 0 2 2 2 0 Nudix N-terminal Nipped-B_C PF12830.7 CCF46212.1 - 5.2e-50 170.0 2.3 5.2e-50 170.0 2.3 2.9 3 0 0 3 3 3 1 Sister chromatid cohesion C-terminus Adaptin_N PF01602.20 CCF46212.1 - 4.1e-07 29.0 0.1 1.7e-05 23.6 0.0 2.9 3 0 0 3 3 3 1 Adaptin N terminal region Cohesin_HEAT PF12765.7 CCF46212.1 - 3.8e-06 27.1 1.9 1.4e-05 25.3 0.5 2.6 2 0 0 2 2 2 1 HEAT repeat associated with sister chromatid cohesion HEAT PF02985.22 CCF46212.1 - 8e-05 22.6 1.0 0.7 10.3 0.0 4.5 4 0 0 4 4 4 2 HEAT repeat NT5C PF06941.12 CCF46212.1 - 0.0012 18.8 0.1 0.0026 17.7 0.1 1.5 1 0 0 1 1 1 1 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) Cnd1 PF12717.7 CCF46212.1 - 0.0023 18.0 0.1 0.051 13.6 0.0 2.7 1 1 1 2 2 2 1 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 CCF46212.1 - 0.015 14.9 0.4 3.7 7.0 0.0 3.4 3 0 0 3 3 3 0 CLASP N terminal HEAT_2 PF13646.6 CCF46212.1 - 0.1 13.0 0.6 3.3 8.2 0.1 3.4 2 1 2 4 4 4 0 HEAT repeats FNIP_N PF14636.6 CCF46213.1 - 1e-41 143.5 0.2 1e-41 143.5 0.2 4.1 4 1 0 4 4 4 1 Folliculin-interacting protein N-terminus FNIP_M PF14637.6 CCF46213.1 - 0.033 14.2 0.1 0.35 10.9 0.0 2.1 1 1 1 2 2 2 0 Folliculin-interacting protein middle domain tRNA-synt_1 PF00133.22 CCF46214.1 - 3.3e-60 204.0 0.0 4.7e-60 203.5 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 CCF46214.1 - 5.7e-18 65.3 0.0 1.1e-17 64.4 0.0 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 CCF46214.1 - 0.00034 19.5 0.0 0.18 10.5 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (M) zf-FPG_IleRS PF06827.14 CCF46214.1 - 0.069 13.0 4.9 0.39 10.6 4.9 2.3 1 1 0 1 1 1 0 Zinc finger found in FPG and IleRS Paramyxo_NS_C PF02725.14 CCF46214.1 - 0.085 13.0 0.4 0.88 9.7 0.1 2.2 1 1 1 2 2 2 0 Non-structural protein C EFG_C PF00679.24 CCF46215.1 - 7.4e-18 64.4 0.0 1e-17 63.9 0.0 1.2 1 0 0 1 1 1 1 Elongation factor G C-terminus DHFR_2 PF06442.11 CCF46215.1 - 0.1 12.5 0.0 0.48 10.3 0.0 1.9 2 0 0 2 2 2 0 R67 dihydrofolate reductase DDE_1 PF03184.19 CCF46216.1 - 3.9e-14 52.7 0.1 1.3e-13 51.0 0.1 1.9 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_psq PF05225.16 CCF46216.1 - 2e-11 43.4 0.1 3.9e-11 42.5 0.1 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.16 CCF46216.1 - 5.6e-11 42.3 0.2 2.4e-10 40.3 0.0 2.1 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_23 PF13384.6 CCF46216.1 - 0.00026 20.7 0.1 0.00083 19.1 0.1 1.9 1 0 0 1 1 1 1 Homeodomain-like domain HTH_7 PF02796.15 CCF46216.1 - 0.0016 18.5 0.1 0.0032 17.5 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_30 PF13556.6 CCF46216.1 - 0.0048 16.7 0.1 0.011 15.5 0.1 1.6 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain HTH_28 PF13518.6 CCF46216.1 - 0.0095 16.0 0.1 0.031 14.4 0.1 2.0 1 1 0 1 1 1 1 Helix-turn-helix domain HTH_Tnp_1 PF01527.20 CCF46216.1 - 0.039 14.3 0.2 0.11 12.8 0.1 1.7 1 1 0 1 1 1 0 Transposase HTH_1 PF00126.27 CCF46216.1 - 0.076 13.0 0.8 0.16 11.9 0.8 1.5 1 0 0 1 1 1 0 Bacterial regulatory helix-turn-helix protein, lysR family CENP-B_N PF04218.13 CCF46216.1 - 0.14 11.8 0.0 0.32 10.7 0.0 1.5 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HTH_psq PF05225.16 CCF46217.1 - 1.8e-12 46.7 0.1 3e-12 46.1 0.1 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_23 PF13384.6 CCF46217.1 - 4.3e-05 23.2 0.1 7.2e-05 22.5 0.1 1.5 1 1 0 1 1 1 1 Homeodomain-like domain HTH_7 PF02796.15 CCF46217.1 - 0.00016 21.6 0.1 0.00029 20.9 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_30 PF13556.6 CCF46217.1 - 0.00065 19.4 0.1 0.001 18.8 0.1 1.4 1 1 0 1 1 1 1 PucR C-terminal helix-turn-helix domain HTH_28 PF13518.6 CCF46217.1 - 0.0015 18.6 0.2 0.0028 17.7 0.1 1.5 1 1 0 1 1 1 1 Helix-turn-helix domain HTH_Tnp_1 PF01527.20 CCF46217.1 - 0.0036 17.6 0.2 0.0044 17.3 0.2 1.3 1 1 0 1 1 1 1 Transposase HTH_1 PF00126.27 CCF46217.1 - 0.0065 16.4 0.9 0.013 15.4 0.6 1.6 1 1 1 2 2 2 1 Bacterial regulatory helix-turn-helix protein, lysR family CENP-B_N PF04218.13 CCF46217.1 - 0.023 14.4 0.0 0.031 13.9 0.0 1.3 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain SpoIIID PF12116.8 CCF46217.1 - 0.03 14.4 0.0 0.046 13.8 0.0 1.4 1 1 0 1 1 1 0 Stage III sporulation protein D HTH_8 PF02954.19 CCF46217.1 - 0.043 13.6 0.5 0.59 10.0 0.1 2.2 1 1 1 2 2 2 0 Bacterial regulatory protein, Fis family HTH_29 PF13551.6 CCF46217.1 - 0.056 13.5 0.0 0.12 12.4 0.0 1.6 1 1 0 1 1 1 0 Winged helix-turn helix HTH_50 PF18024.1 CCF46217.1 - 0.056 13.1 0.0 0.13 11.8 0.0 1.7 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_38 PF13936.6 CCF46217.1 - 0.1 12.3 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_psq PF05225.16 CCF46218.1 - 2.6e-08 33.5 0.6 4.8e-08 32.6 0.1 1.8 2 0 0 2 2 2 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.16 CCF46218.1 - 8.2e-05 22.6 0.0 0.00016 21.6 0.0 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_AsnC-type PF13404.6 CCF46218.1 - 0.0045 16.8 0.1 0.016 15.1 0.1 1.9 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_23 PF13384.6 CCF46218.1 - 0.024 14.5 0.1 0.065 13.1 0.1 1.7 1 0 0 1 1 1 0 Homeodomain-like domain MFS_1 PF07690.16 CCF46220.1 - 8.8e-34 117.0 26.1 8.8e-34 117.0 26.1 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily SpoVAB PF13782.6 CCF46220.1 - 0.016 15.5 1.2 0.016 15.5 1.2 2.3 2 1 0 2 2 2 0 Stage V sporulation protein AB Phage_holin_2_4 PF16082.5 CCF46220.1 - 0.35 10.6 5.8 2.4 8.0 0.0 3.2 3 0 0 3 3 3 0 Bacteriophage holin family, superfamily II-like ADH_zinc_N PF00107.26 CCF46221.1 - 1.1e-24 86.9 1.0 1.4e-24 86.5 0.7 1.3 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCF46221.1 - 8.5e-22 78.6 0.0 1.1e-21 78.3 0.0 1.1 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Prp19 PF08606.11 CCF46222.1 - 9e-33 112.1 2.8 1.8e-32 111.1 2.8 1.5 1 0 0 1 1 1 1 Prp19/Pso4-like WD40 PF00400.32 CCF46222.1 - 3.3e-12 46.7 0.6 5.6e-05 23.8 0.0 5.2 5 0 0 5 5 5 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF46222.1 - 1.2e-11 44.7 0.0 0.036 14.4 0.0 5.2 1 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Coatomer_WDAD PF04053.14 CCF46222.1 - 4.8e-05 22.6 0.0 0.035 13.2 0.0 2.1 1 1 1 2 2 2 2 Coatomer WD associated region V_ATPase_I_N PF18670.1 CCF46222.1 - 0.0012 19.2 0.9 0.0035 17.7 0.6 1.9 2 0 0 2 2 2 1 V-type ATPase subunit I, N-terminal domain U-box PF04564.15 CCF46222.1 - 0.0027 17.8 0.0 0.0053 16.9 0.0 1.4 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.8 CCF46222.1 - 0.0033 17.2 0.0 0.0084 15.9 0.0 1.7 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit eIF2A PF08662.11 CCF46222.1 - 0.0064 16.4 0.0 3 7.7 0.0 2.3 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A HPS3_N PF14761.6 CCF46222.1 - 0.012 15.1 0.0 0.51 9.8 0.0 2.3 2 0 0 2 2 2 0 Hermansky-Pudlak syndrome 3 VID27 PF08553.10 CCF46222.1 - 0.018 14.1 0.0 0.032 13.3 0.0 1.3 1 0 0 1 1 1 0 VID27 C-terminal WD40-like domain Lactonase PF10282.9 CCF46222.1 - 0.048 12.9 0.0 0.24 10.6 0.0 2.0 1 1 1 2 2 2 0 Lactonase, 7-bladed beta-propeller Sun2_CC2 PF18580.1 CCF46222.1 - 0.13 12.5 1.1 4 7.7 0.0 3.2 3 0 0 3 3 3 0 SUN2 coiled coil domain 2 OHCU_decarbox PF09349.10 CCF46223.1 - 4.5e-47 160.4 0.9 5.1e-47 160.2 0.9 1.0 1 0 0 1 1 1 1 OHCU decarboxylase tRNA-synt_His PF13393.6 CCF46223.1 - 0.049 12.9 0.5 0.061 12.6 0.5 1.2 1 0 0 1 1 1 0 Histidyl-tRNA synthetase zf-C2H2_6 PF13912.6 CCF46223.1 - 0.1 12.6 2.4 0.63 10.1 0.0 2.7 3 0 0 3 3 3 0 C2H2-type zinc finger Amino_oxidase PF01593.24 CCF46224.1 - 4.4e-62 210.8 1.8 2.3e-61 208.5 1.8 1.8 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CCF46224.1 - 1.2e-17 63.9 0.5 3.4e-16 59.2 0.3 2.7 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CCF46224.1 - 6.8e-10 39.1 3.2 1.4e-09 38.0 3.2 1.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 CCF46224.1 - 6.2e-06 26.7 1.3 0.0049 17.4 0.2 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CCF46224.1 - 6.4e-06 25.5 1.2 6.4e-06 25.5 1.2 1.8 3 0 0 3 3 3 1 FAD binding domain HI0933_like PF03486.14 CCF46224.1 - 6.8e-06 25.0 0.4 0.00019 20.3 0.1 2.1 2 0 0 2 2 2 1 HI0933-like protein FAD_oxidored PF12831.7 CCF46224.1 - 2.6e-05 23.8 1.0 4.9e-05 22.9 1.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 CCF46224.1 - 4.9e-05 22.7 0.7 7.7e-05 22.0 0.2 1.5 2 0 0 2 2 2 1 Thi4 family Pyr_redox_2 PF07992.14 CCF46224.1 - 0.00028 20.2 1.8 0.00073 18.8 0.2 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 CCF46224.1 - 0.00049 19.4 0.9 0.0011 18.2 0.1 1.8 2 0 0 2 2 2 1 FAD binding domain GIDA PF01134.22 CCF46224.1 - 0.009 15.1 0.3 0.013 14.6 0.3 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 CCF46224.1 - 0.015 14.5 0.5 0.045 13.0 0.1 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CCF46224.1 - 0.024 14.6 0.6 6.1 6.8 0.1 2.6 3 0 0 3 3 3 0 FAD-NAD(P)-binding Lycopene_cycl PF05834.12 CCF46224.1 - 0.069 12.2 1.9 0.097 11.7 0.8 1.7 2 0 0 2 2 2 0 Lycopene cyclase protein Ank_4 PF13637.6 CCF46226.1 - 0.016 15.8 0.0 8.5 7.1 0.0 3.3 3 0 0 3 3 3 0 Ankyrin repeats (many copies) Ank PF00023.30 CCF46226.1 - 0.025 15.0 0.8 0.18 12.3 0.0 2.7 3 0 0 3 3 3 0 Ankyrin repeat ACT_7 PF13840.6 CCF46227.1 - 2.6e-22 78.4 0.5 9.5e-20 70.2 0.1 2.5 2 0 0 2 2 2 2 ACT domain Fungal_trans PF04082.18 CCF46228.1 - 1.4e-13 50.5 0.0 2.5e-13 49.7 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain CAP_N PF01213.19 CCF46228.1 - 0.52 9.8 12.0 0.089 12.3 3.2 2.3 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal HET PF06985.11 CCF46230.1 - 3.9e-33 114.8 0.2 8.3e-33 113.8 0.0 1.6 2 0 0 2 2 2 1 Heterokaryon incompatibility protein (HET) HTH_32 PF13565.6 CCF46230.1 - 0.15 12.7 1.2 0.38 11.4 1.2 1.6 1 0 0 1 1 1 0 Homeodomain-like domain Pro_isomerase PF00160.21 CCF46231.1 - 1.2e-23 84.1 0.0 1.5e-23 83.8 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD HTH_psq PF05225.16 CCF46234.1 - 5.7e-11 42.0 0.0 1.2e-10 40.9 0.0 1.6 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.16 CCF46234.1 - 3.6e-09 36.5 0.1 8.6e-09 35.3 0.0 1.7 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_23 PF13384.6 CCF46234.1 - 0.0031 17.2 0.1 0.03 14.1 0.0 2.3 2 0 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.6 CCF46234.1 - 0.03 14.4 0.1 0.22 11.7 0.0 2.4 3 0 0 3 3 3 0 Helix-turn-helix domain Egh16-like PF11327.8 CCF46235.1 - 1.2e-43 149.6 6.0 1.4e-43 149.5 6.0 1.0 1 0 0 1 1 1 1 Egh16-like virulence factor DUF824 PF05688.11 CCF46235.1 - 0.014 15.2 0.2 0.048 13.5 0.2 1.9 1 0 0 1 1 1 0 Salmonella repeat of unknown function (DUF824) Mitoc_L55 PF09776.9 CCF46236.1 - 0.15 11.8 0.0 0.21 11.4 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L55 DUF3098 PF11297.8 CCF46238.1 - 0.13 11.9 0.0 0.21 11.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3098) EPSP_synthase PF00275.20 CCF46240.1 - 6.6e-130 433.5 0.0 1.5e-129 432.4 0.0 1.5 2 0 0 2 2 2 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) DHQ_synthase PF01761.20 CCF46240.1 - 9.7e-102 339.6 0.0 1.5e-101 339.0 0.0 1.3 1 0 0 1 1 1 1 3-dehydroquinate synthase DHquinase_I PF01487.15 CCF46240.1 - 7.6e-59 199.7 0.0 1.4e-58 198.9 0.0 1.4 1 0 0 1 1 1 1 Type I 3-dehydroquinase SKI PF01202.22 CCF46240.1 - 3.7e-36 124.6 0.0 9.4e-35 120.1 0.0 2.3 2 0 0 2 2 2 1 Shikimate kinase Shikimate_dh_N PF08501.11 CCF46240.1 - 1.4e-22 79.8 0.0 3.1e-22 78.6 0.0 1.7 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain Fe-ADH_2 PF13685.6 CCF46240.1 - 5.9e-09 36.0 0.0 1.3e-08 34.9 0.0 1.5 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase SDH_C PF18317.1 CCF46240.1 - 0.00046 19.9 0.1 0.0013 18.5 0.1 1.8 1 0 0 1 1 1 1 Shikimate 5'-dehydrogenase C-terminal domain AAA_22 PF13401.6 CCF46240.1 - 0.14 12.5 0.0 0.51 10.6 0.0 2.0 1 0 0 1 1 1 0 AAA domain zf-C2H2 PF00096.26 CCF46241.1 - 1.4e-08 34.7 19.5 0.0064 16.9 1.6 4.5 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCF46241.1 - 0.00083 20.0 11.4 2 9.5 1.3 4.3 3 0 0 3 3 3 3 C2H2-type zinc finger p450 PF00067.22 CCF46242.1 - 2.4e-11 43.1 0.0 3e-11 42.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Glyco_hydro_cc PF11790.8 CCF46244.1 - 9.9e-34 117.0 0.0 1.1e-33 116.8 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core JmjN PF02375.17 CCF46245.1 - 0.0017 18.3 0.4 0.0026 17.7 0.4 1.3 1 0 0 1 1 1 1 jmjN domain Dynamin_N PF00350.23 CCF46250.1 - 6.2e-19 68.7 1.6 1.1e-17 64.7 0.0 3.1 2 1 1 3 3 3 1 Dynamin family MMR_HSR1 PF01926.23 CCF46250.1 - 7.9e-06 25.9 0.0 0.00015 21.8 0.0 2.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CCF46250.1 - 0.00074 19.5 0.0 0.0089 15.9 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase ABC_tran PF00005.27 CCF46250.1 - 0.001 19.6 0.0 0.001 19.6 0.0 2.9 2 1 0 2 2 2 1 ABC transporter AAA_16 PF13191.6 CCF46250.1 - 0.0023 18.3 3.5 0.0065 16.9 0.1 3.4 3 2 0 3 3 3 1 AAA ATPase domain IIGP PF05049.13 CCF46250.1 - 0.013 14.6 0.0 0.036 13.1 0.0 1.7 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) DUF3395 PF11875.8 CCF46250.1 - 0.015 15.2 2.0 0.041 13.8 2.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3395) AAA_22 PF13401.6 CCF46250.1 - 0.017 15.4 0.2 0.34 11.2 0.2 3.0 1 1 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 CCF46250.1 - 0.022 14.1 0.0 0.16 11.2 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin AIG1 PF04548.16 CCF46250.1 - 0.16 11.3 0.0 0.16 11.3 0.0 2.7 4 0 0 4 4 4 0 AIG1 family DUF908 PF06012.12 CCF46250.1 - 0.17 11.3 9.3 0.42 10.0 9.3 1.6 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) MFMR_assoc PF16596.5 CCF46250.1 - 0.28 11.6 6.5 0.71 10.3 5.9 2.0 2 0 0 2 2 2 0 Disordered region downstream of MFMR FlaC_arch PF05377.11 CCF46250.1 - 1.5 9.3 15.8 2.3 8.6 0.3 4.5 4 1 1 5 5 5 0 Flagella accessory protein C (FlaC) DUF1664 PF07889.12 CCF46250.1 - 4.1 7.5 10.5 11 6.1 2.3 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) ZapB PF06005.12 CCF46250.1 - 4.6 7.8 17.8 1 9.8 0.1 4.0 5 0 0 5 5 4 0 Cell division protein ZapB POX PF07526.11 CCF46250.1 - 5.2 7.6 8.3 5.6 7.5 5.4 2.5 2 0 0 2 2 2 0 Associated with HOX DUF1304 PF06993.12 CCF46251.1 - 7.8e-44 148.2 3.0 8.8e-44 148.0 3.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1304) Pribosyltran PF00156.27 CCF46253.1 - 1.2e-16 60.6 0.7 2e-16 59.9 0.7 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 CCF46253.1 - 0.12 11.9 0.0 0.18 11.2 0.0 1.2 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase Thg1C PF14413.6 CCF46254.1 - 4.4e-08 33.3 0.3 6.1e-08 32.9 0.3 1.2 1 0 0 1 1 1 1 Thg1 C terminal domain MAP7 PF05672.11 CCF46254.1 - 0.0021 17.8 1.5 0.0026 17.4 1.5 1.1 1 0 0 1 1 1 1 MAP7 (E-MAP-115) family NAM-associated PF14303.6 CCF46255.1 - 0.5 11.1 23.5 0.95 10.2 23.5 1.4 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain SRP-alpha_N PF04086.13 CCF46255.1 - 0.92 9.4 29.8 1.7 8.5 29.8 1.4 1 1 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Hamartin PF04388.12 CCF46255.1 - 1 7.9 8.6 1.2 7.8 8.6 1.0 1 0 0 1 1 1 0 Hamartin protein GREB1 PF15782.5 CCF46255.1 - 5 4.1 7.0 5.4 4.0 7.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Presenilin PF01080.17 CCF46255.1 - 5.4 5.7 15.0 7.1 5.3 15.0 1.3 1 0 0 1 1 1 0 Presenilin Nop53 PF07767.11 CCF46255.1 - 6.5 6.0 36.8 9.7 5.5 36.8 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Neur_chan_memb PF02932.16 CCF46255.1 - 6.6 6.7 6.9 9.2 6.2 6.9 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region TP_methylase PF00590.20 CCF46256.1 - 6.4e-05 23.0 0.0 0.00011 22.2 0.0 1.6 1 1 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases TCL1_MTCP1 PF01840.17 CCF46256.1 - 0.098 12.3 0.0 0.18 11.4 0.0 1.4 1 0 0 1 1 1 0 TCL1/MTCP1 family F-box-like PF12937.7 CCF46257.1 - 0.0031 17.4 0.0 0.006 16.4 0.0 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCF46257.1 - 0.025 14.4 0.0 0.049 13.5 0.0 1.5 1 0 0 1 1 1 0 F-box domain DUF2378 PF09536.10 CCF46258.1 - 0.035 14.0 0.4 0.057 13.3 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2378) Tyrosinase PF00264.20 CCF46259.1 - 3.3e-19 70.1 1.9 5.8e-15 56.2 0.1 2.3 2 0 0 2 2 2 2 Common central domain of tyrosinase Tyosinase_C PF18132.1 CCF46259.1 - 0.0084 16.8 0.0 0.061 14.0 0.0 2.1 1 1 0 1 1 1 1 Tyosinase C-terminal domain Glyco_hydro_43 PF04616.14 CCF46260.1 - 6.2e-52 176.7 0.5 8.4e-52 176.3 0.5 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 GH43_C2 PF17851.1 CCF46260.1 - 1.1e-15 57.9 0.0 1.5e-15 57.5 0.0 1.2 1 0 0 1 1 1 1 Beta xylosidase C-terminal Concanavalin A-like domain DUF1349 PF07081.11 CCF46260.1 - 0.0031 17.3 0.0 0.0051 16.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1349) FAD_binding_3 PF01494.19 CCF46261.1 - 3.4e-43 148.2 0.0 4.9e-43 147.7 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 CCF46261.1 - 4.2e-07 30.1 0.2 9.4e-07 29.0 0.2 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CCF46261.1 - 1.3e-06 28.2 0.2 0.0005 19.8 0.1 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCF46261.1 - 0.00013 21.3 0.0 0.00026 20.3 0.0 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CCF46261.1 - 0.00025 19.9 0.0 0.00057 18.7 0.0 1.6 1 1 0 1 1 1 1 HI0933-like protein FAD_oxidored PF12831.7 CCF46261.1 - 0.00056 19.4 0.1 0.0053 16.2 0.1 2.0 1 1 0 1 1 1 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 CCF46261.1 - 0.00056 19.1 0.1 0.0018 17.4 0.1 1.7 2 0 0 2 2 2 1 Lycopene cyclase protein Pyr_redox PF00070.27 CCF46261.1 - 0.0009 19.8 0.0 0.0023 18.5 0.0 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 CCF46261.1 - 0.0012 18.2 0.5 1.5 8.0 0.1 3.2 2 1 0 2 2 2 2 Flavin containing amine oxidoreductase FAD_binding_2 PF00890.24 CCF46261.1 - 0.0022 17.1 1.6 0.028 13.5 0.6 2.1 1 1 1 2 2 2 1 FAD binding domain Thi4 PF01946.17 CCF46261.1 - 0.0068 15.7 0.1 0.01 15.1 0.1 1.2 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.6 CCF46261.1 - 0.0074 15.6 0.0 0.012 14.9 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CCF46261.1 - 0.11 12.5 0.1 0.59 10.1 0.1 2.0 2 0 0 2 2 2 0 FAD-NAD(P)-binding ATP-synt_ab PF00006.25 CCF46262.1 - 2e-108 361.0 0.0 2.7e-108 360.5 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_Xtn PF16886.5 CCF46262.1 - 4e-47 159.0 0.0 8.7e-47 158.0 0.0 1.6 1 0 0 1 1 1 1 ATPsynthase alpha/beta subunit N-term extension ATP-synt_ab_N PF02874.23 CCF46262.1 - 3.4e-15 56.3 2.8 9.2e-15 54.9 2.8 1.8 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain LPD23 PF18838.1 CCF46262.1 - 0.015 15.0 0.1 0.032 14.0 0.1 1.5 1 0 0 1 1 1 0 Large polyvalent protein associated domain 23 DUF4048 PF13257.6 CCF46263.1 - 2e-14 54.1 0.2 2e-14 54.1 0.2 4.4 4 1 1 5 5 5 2 Domain of unknown function (DUF4048) AzlD PF05437.12 CCF46264.1 - 0.094 12.9 1.1 0.17 12.0 1.1 1.4 1 0 0 1 1 1 0 Branched-chain amino acid transport protein (AzlD) Androgen_recep PF02166.16 CCF46264.1 - 1 8.1 4.6 4.1 6.1 0.1 2.0 2 0 0 2 2 2 0 Androgen receptor Glyco_hydro_28 PF00295.17 CCF46266.1 - 1.2e-44 152.7 8.2 1.8e-44 152.1 8.2 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Beta_helix PF13229.6 CCF46266.1 - 0.81 9.5 10.3 0.99 9.2 9.0 1.9 1 1 1 2 2 2 0 Right handed beta helix region Peptidase_S10 PF00450.22 CCF46267.1 - 1.2e-08 34.9 0.1 1.4e-08 34.6 0.1 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Methyltransf_23 PF13489.6 CCF46269.1 - 0.00087 19.2 0.0 0.0015 18.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CCF46269.1 - 0.0081 15.7 0.0 0.014 15.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain GidB PF02527.15 CCF46269.1 - 0.0083 15.5 0.0 0.011 15.1 0.0 1.1 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G PCMT PF01135.19 CCF46269.1 - 0.045 13.5 0.0 0.061 13.1 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_25 PF13649.6 CCF46269.1 - 0.16 12.7 0.0 0.31 11.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain NST1 PF13945.6 CCF46270.1 - 3e-58 197.1 6.3 3e-58 197.1 6.3 4.2 2 2 2 4 4 4 1 Salt tolerance down-regulator Glyco_hydro_16 PF00722.21 CCF46271.1 - 8.3e-10 38.4 5.0 1.3e-09 37.8 5.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 PilW PF16074.5 CCF46271.1 - 0.086 12.8 0.2 0.21 11.6 0.2 1.7 1 1 0 1 1 1 0 Type IV Pilus-assembly protein W Glyco_hydro_16 PF00722.21 CCF46273.1 - 1.8e-32 112.2 1.7 2.5e-32 111.8 0.2 1.9 1 1 1 2 2 2 1 Glycosyl hydrolases family 16 SOG2 PF10428.9 CCF46273.1 - 0.56 9.4 4.4 0.73 9.0 4.4 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Condensation PF00668.20 CCF46274.1 - 3.9e-63 213.7 0.0 5.1e-63 213.3 0.0 1.1 1 0 0 1 1 1 1 Condensation domain AMP-binding PF00501.28 CCF46274.1 - 5.4e-27 94.4 0.3 9e-27 93.7 0.3 1.3 1 0 0 1 1 1 1 AMP-binding enzyme NIR_SIR_ferr PF03460.17 CCF46274.1 - 0.072 12.9 0.0 0.53 10.2 0.0 2.4 2 0 0 2 2 2 0 Nitrite/Sulfite reductase ferredoxin-like half domain DS PF01916.17 CCF46275.1 - 2.4e-122 407.7 0.0 2.9e-122 407.5 0.0 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase Abhydrolase_6 PF12697.7 CCF46276.1 - 0.0047 17.5 1.3 0.0047 17.5 1.3 2.2 2 2 0 2 2 2 1 Alpha/beta hydrolase family Thioesterase PF00975.20 CCF46276.1 - 0.005 17.0 0.0 0.016 15.3 0.0 1.7 2 0 0 2 2 2 1 Thioesterase domain BTB PF00651.31 CCF46277.1 - 0.00079 19.6 0.0 0.0019 18.4 0.0 1.6 2 0 0 2 2 2 1 BTB/POZ domain SPECT1 PF18680.1 CCF46277.1 - 0.036 13.7 0.1 0.071 12.8 0.1 1.5 1 0 0 1 1 1 0 Plasmodium host cell traversal SPECT1 Hce2 PF14856.6 CCF46278.1 - 5.4e-16 58.7 0.1 7.5e-16 58.3 0.1 1.2 1 0 0 1 1 1 1 Pathogen effector; putative necrosis-inducing factor Abhydrolase_3 PF07859.13 CCF46279.1 - 1.6e-10 41.2 0.0 4.2e-10 39.8 0.0 1.7 2 0 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CCF46279.1 - 0.0033 16.9 0.0 0.1 12.1 0.0 2.1 2 0 0 2 2 2 1 Prolyl oligopeptidase family Esterase_phd PF10503.9 CCF46279.1 - 0.044 13.3 0.1 3.2 7.2 0.0 2.2 2 0 0 2 2 2 0 Esterase PHB depolymerase Hydrolase_4 PF12146.8 CCF46279.1 - 0.13 11.5 0.1 0.51 9.6 0.0 1.9 2 0 0 2 2 2 0 Serine aminopeptidase, S33 DUF4431 PF14485.6 CCF46279.1 - 0.16 11.8 0.0 0.53 10.1 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4431) Sulfate_transp PF00916.20 CCF46280.1 - 3.6e-79 266.3 10.9 5.1e-79 265.8 10.9 1.2 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 CCF46280.1 - 1.9e-15 56.5 0.0 4.2e-15 55.4 0.0 1.6 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.6 CCF46280.1 - 0.0003 21.1 0.0 0.00086 19.6 0.0 1.8 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 CCF46280.1 - 0.00094 19.6 2.2 0.00094 19.6 2.2 2.5 2 0 0 2 2 2 1 Molybdate transporter of MFS superfamily DUF4166 PF13761.6 CCF46280.1 - 0.024 14.4 0.0 1.2 8.9 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4166) RRM_1 PF00076.22 CCF46281.1 - 0.078 12.8 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Peptidase_S8 PF00082.22 CCF46282.1 - 1.3e-25 90.3 3.7 1.8e-25 89.8 3.7 1.1 1 0 0 1 1 1 1 Subtilase family cobW PF02492.19 CCF46284.1 - 4.4e-50 169.7 4.3 1e-36 126.2 0.3 2.2 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 CCF46284.1 - 1.2e-06 27.8 0.4 0.00026 20.1 0.0 2.2 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB RsgA_GTPase PF03193.16 CCF46284.1 - 0.0017 18.3 0.5 0.61 10.0 0.1 2.4 2 0 0 2 2 2 1 RsgA GTPase MobB PF03205.14 CCF46284.1 - 0.0029 17.5 0.0 0.0055 16.6 0.0 1.4 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B Viral_helicase1 PF01443.18 CCF46284.1 - 0.0058 16.4 0.0 0.014 15.2 0.0 1.6 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase Sigma70_ner PF04546.13 CCF46284.1 - 0.013 15.4 6.3 0.029 14.3 6.3 1.7 1 0 0 1 1 1 0 Sigma-70, non-essential region TsaE PF02367.17 CCF46284.1 - 0.015 15.3 0.0 0.032 14.2 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_16 PF13191.6 CCF46284.1 - 0.015 15.6 2.2 0.021 15.2 0.3 2.2 2 1 0 2 2 2 0 AAA ATPase domain AAA_33 PF13671.6 CCF46284.1 - 0.052 13.7 0.1 0.17 12.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain GTP_EFTU PF00009.27 CCF46284.1 - 0.059 12.9 0.7 3 7.3 0.1 2.4 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain CDC45 PF02724.14 CCF46284.1 - 0.067 11.5 8.8 0.09 11.1 8.8 1.2 1 0 0 1 1 1 0 CDC45-like protein TFIIA PF03153.13 CCF46284.1 - 0.069 13.1 13.4 0.1 12.6 13.4 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit AAA_29 PF13555.6 CCF46284.1 - 0.099 12.4 0.0 0.26 11.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain ATP_bind_1 PF03029.17 CCF46284.1 - 0.1 12.4 0.4 19 5.0 0.0 2.7 2 1 1 3 3 3 0 Conserved hypothetical ATP binding protein NACHT PF05729.12 CCF46284.1 - 0.11 12.5 0.1 0.34 10.8 0.1 1.9 1 0 0 1 1 1 0 NACHT domain RNA_pol_3_Rpc31 PF11705.8 CCF46284.1 - 0.23 11.7 16.8 0.4 10.9 16.8 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 PPP4R2 PF09184.11 CCF46284.1 - 0.28 10.7 11.6 0.46 10.0 11.6 1.3 1 0 0 1 1 1 0 PPP4R2 SDA1 PF05285.12 CCF46284.1 - 0.44 9.9 16.0 0.61 9.5 16.0 1.2 1 0 0 1 1 1 0 SDA1 AAA_11 PF13086.6 CCF46284.1 - 0.63 9.8 3.0 2.8 7.7 0.1 2.6 2 1 0 3 3 3 0 AAA domain AAA_18 PF13238.6 CCF46284.1 - 0.75 10.3 0.0 0.75 10.3 0.0 2.6 3 0 0 3 3 2 0 AAA domain Cwf_Cwc_15 PF04889.12 CCF46284.1 - 3.8 7.2 18.7 7.6 6.2 18.7 1.5 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein RRN3 PF05327.11 CCF46284.1 - 5 5.5 14.8 7.7 4.9 14.8 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Nop14 PF04147.12 CCF46284.1 - 7.3 4.7 22.0 9.8 4.2 22.0 1.1 1 0 0 1 1 1 0 Nop14-like family KH_8 PF17903.1 CCF46286.1 - 0.0012 18.9 0.0 0.0025 17.8 0.0 1.5 1 0 0 1 1 1 1 Krr1 KH1 domain KH_1 PF00013.29 CCF46286.1 - 0.0039 17.0 0.8 0.0074 16.1 0.8 1.5 1 0 0 1 1 1 1 KH domain Nuc_sug_transp PF04142.15 CCF46287.1 - 4.1e-11 42.6 5.7 5e-10 39.0 7.6 1.7 2 0 0 2 2 2 1 Nucleotide-sugar transporter 2OG-FeII_Oxy_2 PF13532.6 CCF46288.1 - 5.8e-06 26.6 0.0 2.1e-05 24.8 0.0 1.9 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Steroid_dh PF02544.16 CCF46289.1 - 9.2e-15 54.9 1.1 2e-14 53.8 1.1 1.7 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.12 CCF46289.1 - 0.0057 16.2 1.5 0.0097 15.4 0.9 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF1295) PEMT PF04191.13 CCF46289.1 - 0.11 13.0 4.6 0.12 12.8 0.1 3.0 3 0 0 3 3 3 0 Phospholipid methyltransferase DUF2235 PF09994.9 CCF46290.1 - 9.3e-83 277.9 0.0 1.3e-82 277.4 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) Arm PF00514.23 CCF46291.1 - 3.3e-44 147.6 1.2 1.5e-13 50.2 0.0 4.5 5 0 0 5 5 5 3 Armadillo/beta-catenin-like repeat IBB PF01749.20 CCF46291.1 - 2e-28 98.6 1.0 3.7e-28 97.8 1.0 1.4 1 0 0 1 1 1 1 Importin beta binding domain HEAT_2 PF13646.6 CCF46291.1 - 5.7e-17 61.9 0.2 4.2e-09 36.7 0.0 2.7 1 1 2 3 3 3 3 HEAT repeats HEAT_EZ PF13513.6 CCF46291.1 - 1.5e-12 47.7 3.2 2.7e-09 37.3 0.1 3.2 3 1 0 3 3 3 2 HEAT-like repeat HEAT PF02985.22 CCF46291.1 - 6.4e-11 41.6 0.1 6.9e-06 25.9 0.0 3.5 3 0 0 3 3 3 2 HEAT repeat HEAT_PBS PF03130.16 CCF46291.1 - 0.0013 19.2 1.4 0.71 10.7 0.0 3.5 4 0 0 4 4 4 1 PBS lyase HEAT-like repeat Arm_2 PF04826.13 CCF46291.1 - 0.038 13.4 0.0 0.43 10.0 0.0 2.1 1 1 1 2 2 2 0 Armadillo-like RICTOR_V PF14668.6 CCF46291.1 - 0.04 14.2 0.2 1.2 9.4 0.1 2.4 1 1 1 2 2 2 0 Rapamycin-insensitive companion of mTOR, domain 5 NUSAP PF16006.5 CCF46291.1 - 2.2 8.0 5.5 3.1 7.5 5.5 1.2 1 0 0 1 1 1 0 Nucleolar and spindle-associated protein DIL PF01843.19 CCF46292.1 - 6.5e-14 52.1 2.4 6.7e-14 52.0 0.1 2.2 4 0 0 4 4 4 1 DIL domain FAD_binding_3 PF01494.19 CCF46293.1 - 3.9e-11 42.8 0.0 4.6e-11 42.6 0.0 1.0 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 CCF46293.1 - 4.9e-09 36.3 0.3 6.1e-06 26.4 0.1 2.4 1 1 2 3 3 3 2 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 CCF46293.1 - 4.1e-07 29.5 0.3 5.4e-07 29.2 0.3 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CCF46293.1 - 3e-05 23.4 0.0 4.1e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.14 CCF46293.1 - 6.9e-05 22.2 0.0 6.9e-05 22.2 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCF46293.1 - 7.7e-05 22.4 1.4 0.00011 21.9 1.4 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 CCF46293.1 - 8.5e-05 21.4 0.1 0.00011 21.0 0.1 1.1 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_2 PF00890.24 CCF46293.1 - 0.00015 21.0 0.2 0.00019 20.7 0.2 1.1 1 0 0 1 1 1 1 FAD binding domain Amino_oxidase PF01593.24 CCF46293.1 - 0.00034 20.0 0.1 0.0032 16.8 0.1 1.9 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase FAD_oxidored PF12831.7 CCF46293.1 - 0.00052 19.5 0.2 0.00071 19.0 0.2 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Trp_halogenase PF04820.14 CCF46293.1 - 0.0012 17.8 0.0 0.0012 17.8 0.0 1.1 1 0 0 1 1 1 1 Tryptophan halogenase Pyr_redox PF00070.27 CCF46293.1 - 0.0013 19.2 0.2 0.002 18.7 0.2 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CCF46293.1 - 0.0013 17.9 0.1 0.0014 17.8 0.1 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 CCF46293.1 - 0.016 14.5 0.1 0.023 14.0 0.0 1.3 1 1 1 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain TrkA_N PF02254.18 CCF46293.1 - 0.069 13.4 0.0 0.091 13.0 0.0 1.2 1 0 0 1 1 1 0 TrkA-N domain Ufd2P_core PF10408.9 CCF46295.1 - 2.2e-49 168.6 0.3 2.6e-49 168.4 0.3 1.0 1 0 0 1 1 1 1 Ubiquitin elongating factor core U-box PF04564.15 CCF46295.1 - 2e-25 88.8 0.8 3.5e-25 88.0 0.8 1.4 1 0 0 1 1 1 1 U-box domain DUF1184 PF06683.11 CCF46295.1 - 0.078 12.5 0.2 0.84 9.1 0.2 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF1184) E1-E2_ATPase PF00122.20 CCF46298.1 - 1.9e-17 63.4 0.0 4.9e-17 62.0 0.0 1.8 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 CCF46298.1 - 6.4e-13 49.5 3.6 5.5e-07 30.1 3.4 3.2 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CCF46298.1 - 0.0029 17.7 0.0 0.0094 16.0 0.0 1.9 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 CCF46298.1 - 0.014 15.1 0.0 0.15 11.8 0.1 2.3 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase DUF4059 PF13268.6 CCF46298.1 - 0.064 13.7 1.5 13 6.2 0.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4059) Ldh_1_C PF02866.18 CCF46299.1 - 2.1e-46 157.9 0.0 4.4e-46 156.9 0.0 1.5 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 CCF46299.1 - 5.4e-44 149.7 0.1 1e-43 148.8 0.0 1.5 2 0 0 2 2 2 1 lactate/malate dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 CCF46299.1 - 8.4e-05 21.7 0.0 0.00012 21.1 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Glyco_hydro_4 PF02056.16 CCF46299.1 - 0.091 12.3 0.1 0.4 10.2 0.1 2.0 1 1 1 2 2 2 0 Family 4 glycosyl hydrolase zf-C2HC5 PF06221.13 CCF46300.1 - 7.5e-22 77.1 5.9 1.2e-21 76.4 5.9 1.3 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type FYVE PF01363.21 CCF46300.1 - 0.095 12.9 1.7 0.17 12.1 1.7 1.4 1 0 0 1 1 1 0 FYVE zinc finger zf-ribbon_3 PF13248.6 CCF46300.1 - 0.12 11.8 1.8 2.8 7.5 0.2 2.4 2 0 0 2 2 2 0 zinc-ribbon domain FAM176 PF14851.6 CCF46300.1 - 7.9 6.1 6.6 29 4.3 6.5 2.0 1 1 0 1 1 1 0 FAM176 family CFEM PF05730.11 CCF46301.1 - 1e-11 44.7 7.5 2e-11 43.8 7.5 1.5 1 0 0 1 1 1 1 CFEM domain ATG13 PF10033.9 CCF46304.1 - 8.7e-78 261.3 0.0 1.1e-77 261.0 0.0 1.1 1 0 0 1 1 1 1 Autophagy-related protein 13 AGA2 PF17366.2 CCF46304.1 - 0.3 10.8 0.8 0.6 9.8 0.0 1.8 2 0 0 2 2 2 0 A-agglutinin-binding subunit Aga2 DUF3515 PF12028.8 CCF46305.1 - 0.076 12.7 0.0 0.099 12.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3515) RL11D PF11088.8 CCF46306.1 - 0.013 15.8 0.3 0.6 10.4 0.0 2.1 2 0 0 2 2 2 0 Glycoprotein encoding membrane proteins RL5A and RL6 Astro_capsid_p2 PF16580.5 CCF46306.1 - 0.02 14.4 0.0 0.021 14.2 0.0 1.1 1 0 0 1 1 1 0 C-terminal tail of astrovirus capsid projection or spike Glyco_hydro_61 PF03443.14 CCF46308.1 - 1.6e-58 198.1 0.1 1.8e-58 197.9 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 Glutaredoxin PF00462.24 CCF46309.1 - 3.9e-18 65.4 0.0 6.3e-18 64.7 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin DUF836 PF05768.14 CCF46309.1 - 0.00023 21.5 0.1 0.00029 21.2 0.1 1.4 1 1 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Thioredoxin_2 PF13098.6 CCF46309.1 - 0.00029 21.2 0.1 0.00041 20.8 0.1 1.3 1 1 0 1 1 1 1 Thioredoxin-like domain Inos-1-P_synth PF01658.17 CCF46309.1 - 0.00062 20.0 0.3 0.78 10.0 0.0 2.1 2 0 0 2 2 2 2 Myo-inositol-1-phosphate synthase Thioredoxin PF00085.20 CCF46309.1 - 0.0017 18.3 0.0 0.0019 18.2 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin DSBA PF01323.20 CCF46309.1 - 0.0026 17.6 0.1 0.0061 16.4 0.1 1.7 1 1 0 1 1 1 1 DSBA-like thioredoxin domain GST_N_3 PF13417.6 CCF46309.1 - 0.009 16.4 0.0 0.014 15.8 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Thioredoxin_9 PF14595.6 CCF46309.1 - 0.013 15.3 0.0 0.014 15.1 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin TraF PF13728.6 CCF46309.1 - 0.021 14.7 0.0 0.022 14.6 0.0 1.1 1 0 0 1 1 1 0 F plasmid transfer operon protein Thioredoxin_4 PF13462.6 CCF46309.1 - 0.034 14.3 0.3 0.095 12.9 0.2 1.7 1 1 1 2 2 2 0 Thioredoxin Redoxin PF08534.10 CCF46309.1 - 0.14 11.9 0.0 0.15 11.8 0.0 1.2 1 0 0 1 1 1 0 Redoxin Chalcone_2 PF16035.5 CCF46310.1 - 6.2e-80 267.8 0.0 8.3e-80 267.4 0.0 1.2 1 0 0 1 1 1 1 Chalcone isomerase like Chalcone_3 PF16036.5 CCF46310.1 - 0.002 18.3 0.1 0.046 13.8 0.1 2.2 1 1 1 2 2 2 1 Chalcone isomerase-like CBFNT PF08143.11 CCF46311.1 - 0.28 12.6 3.3 0.41 12.1 3.3 1.3 1 0 0 1 1 1 0 CBFNT (NUC161) domain Sugar_tr PF00083.24 CCF46313.1 - 3.5e-105 352.5 20.0 4e-105 352.3 20.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF46313.1 - 1.4e-33 116.3 40.5 2.3e-30 105.8 23.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_5 PF05631.14 CCF46313.1 - 7.7e-06 25.1 1.5 7.7e-06 25.1 1.5 1.8 2 0 0 2 2 2 1 Sugar-tranasporters, 12 TM Aldedh PF00171.22 CCF46314.1 - 8.6e-178 591.6 1.4 9.7e-178 591.4 1.4 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 CCF46314.1 - 0.029 13.8 0.0 0.43 10.0 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1487) RPN6_C_helix PF18503.1 CCF46314.1 - 0.64 9.8 2.2 43 4.0 0.0 3.5 3 0 0 3 3 3 0 26S proteasome subunit RPN6 C-terminal helix domain Alpha-amylase PF00128.24 CCF46315.1 - 2.3e-23 83.3 3.0 5.6e-23 82.0 3.0 1.5 1 1 0 1 1 1 1 Alpha amylase, catalytic domain Glyco_hydro_70 PF02324.16 CCF46315.1 - 6.3e-07 28.0 0.7 0.022 13.0 0.1 3.1 3 0 0 3 3 3 3 Glycosyl hydrolase family 70 DUF1939 PF09154.10 CCF46315.1 - 0.026 14.7 0.3 0.11 12.7 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1939) DUF2232 PF09991.9 CCF46316.1 - 0.14 11.3 0.1 0.14 11.3 0.1 3.0 3 0 0 3 3 3 0 Predicted membrane protein (DUF2232) Peptidase_U4 PF03419.13 CCF46316.1 - 0.37 10.0 8.2 0.78 9.0 8.2 1.5 1 0 0 1 1 1 0 Sporulation factor SpoIIGA Saf_2TM PF18303.1 CCF46317.1 - 0.042 13.4 0.3 0.084 12.5 0.3 1.5 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain TMEM132D_C PF15706.5 CCF46317.1 - 0.12 12.1 0.2 0.25 11.2 0.2 1.4 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term TMEM100 PF16311.5 CCF46317.1 - 3.6 7.2 5.8 0.52 9.9 1.1 1.9 2 0 0 2 2 2 0 Transmembrane protein 100 DUF2517 PF10725.9 CCF46320.1 - 0.097 12.4 0.1 0.17 11.7 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2517) CPSase_L_D2 PF02786.17 CCF46321.1 - 1.9e-70 236.7 0.0 6.1e-59 199.0 0.0 2.3 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_D3 PF02787.19 CCF46321.1 - 8.8e-41 139.1 0.1 3e-40 137.4 0.1 1.9 2 0 0 2 2 2 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain Dala_Dala_lig_C PF07478.13 CCF46321.1 - 3.2e-07 30.1 0.1 0.015 14.9 0.0 2.8 3 0 0 3 3 3 2 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 CCF46321.1 - 1.1e-05 25.1 0.0 0.025 14.2 0.0 2.5 2 0 0 2 2 2 2 ATP-grasp domain ATPgrasp_Ter PF15632.6 CCF46321.1 - 0.00039 20.2 0.0 0.00093 18.9 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_5 PF13549.6 CCF46321.1 - 0.047 13.1 0.0 0.1 12.0 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain GARS_A PF01071.19 CCF46321.1 - 0.072 12.9 0.0 0.34 10.6 0.0 2.1 2 0 0 2 2 2 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain BBE PF08031.12 CCF46322.1 - 1.1e-11 44.6 0.9 2.6e-11 43.4 0.9 1.6 1 0 0 1 1 1 1 Berberine and berberine like FAD_binding_4 PF01565.23 CCF46322.1 - 0.079 12.7 0.0 0.18 11.6 0.0 1.6 1 0 0 1 1 1 0 FAD binding domain CtaG_Cox11 PF04442.14 CCF46323.1 - 1.7e-59 200.2 0.0 2.3e-59 199.7 0.0 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein CtaG/Cox11 DUF3433 PF11915.8 CCF46325.1 - 7.8e-14 51.9 5.2 1.6e-10 41.3 0.4 3.9 4 0 0 4 4 4 2 Protein of unknown function (DUF3433) Ribosomal_S5_C PF03719.15 CCF46327.1 - 1.3e-11 43.8 0.0 1.6e-11 43.5 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain DASH_Dad3 PF08656.10 CCF46328.1 - 8.9e-34 115.4 0.7 1.1e-33 115.1 0.7 1.1 1 0 0 1 1 1 1 DASH complex subunit Dad3 FliG_C PF01706.16 CCF46328.1 - 0.071 13.3 0.1 0.09 13.0 0.1 1.1 1 0 0 1 1 1 0 FliG C-terminal domain NmrA PF05368.13 CCF46329.1 - 1.6e-09 37.7 0.0 1.7e-09 37.6 0.0 1.0 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CCF46329.1 - 6.8e-06 26.1 0.0 7.4e-06 26.0 0.0 1.0 1 0 0 1 1 1 1 NAD(P)H-binding ERG4_ERG24 PF01222.17 CCF46331.1 - 2.7e-140 468.0 7.8 3e-140 467.8 7.8 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 CCF46331.1 - 0.00014 21.5 0.1 0.00033 20.3 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) WSC PF01822.19 CCF46335.1 - 2.5e-13 50.0 9.3 4.6e-13 49.1 9.3 1.5 1 0 0 1 1 1 1 WSC domain TarH PF02203.15 CCF46335.1 - 0.063 13.2 0.2 0.18 11.7 0.1 1.8 2 0 0 2 2 2 0 Tar ligand binding domain homologue HTH_psq PF05225.16 CCF46339.1 - 4.9e-09 35.8 0.0 6.2e-09 35.5 0.0 1.2 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_AsnC-type PF13404.6 CCF46339.1 - 0.035 13.9 0.3 0.052 13.4 0.3 1.3 1 0 0 1 1 1 0 AsnC-type helix-turn-helix domain HTH_23 PF13384.6 CCF46339.1 - 0.1 12.4 0.1 0.15 11.9 0.1 1.3 1 0 0 1 1 1 0 Homeodomain-like domain Fungal_trans_2 PF11951.8 CCF46340.1 - 0.0083 15.0 0.0 0.0091 14.9 0.0 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain MFS_1 PF07690.16 CCF46343.1 - 4.3e-17 62.1 33.8 1.5e-15 57.0 29.5 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF46343.1 - 1.3e-06 27.5 9.4 1.3e-06 27.5 9.4 2.0 2 0 0 2 2 2 1 Sugar (and other) transporter UNC-93 PF05978.16 CCF46343.1 - 0.0021 17.8 5.4 0.0021 17.8 5.4 2.1 2 0 0 2 2 2 1 Ion channel regulatory protein UNC-93 PUCC PF03209.15 CCF46343.1 - 0.0023 17.0 0.6 0.0088 15.1 0.7 1.9 1 1 1 2 2 2 1 PUCC protein MerC PF03203.14 CCF46343.1 - 5 7.6 8.0 0.81 10.2 0.9 2.7 2 1 0 2 2 2 0 MerC mercury resistance protein ABC2_membrane PF01061.24 CCF46345.1 - 5e-06 26.1 2.9 2.6e-05 23.7 0.2 2.0 2 0 0 2 2 2 2 ABC-2 type transporter PDR_CDR PF06422.12 CCF46345.1 - 2.7e-05 24.0 1.0 5e-05 23.1 1.0 1.4 1 0 0 1 1 1 1 CDR ABC transporter CRIM PF16978.5 CCF46346.1 - 1.5e-46 158.0 0.0 9.7e-46 155.4 0.0 2.1 2 0 0 2 2 2 1 SAPK-interacting protein 1 (Sin1), middle CRIM domain SIN1_PH PF16979.5 CCF46346.1 - 5.2e-25 87.8 1.6 1.1e-24 86.9 1.6 1.5 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), Pleckstrin-homology PH PF00169.29 CCF46346.1 - 0.011 16.2 0.2 0.024 15.2 0.2 1.5 1 0 0 1 1 1 0 PH domain TUG-UBL1 PF11470.8 CCF46346.1 - 0.012 15.8 0.0 0.028 14.6 0.0 1.5 1 0 0 1 1 1 0 TUG ubiquitin-like domain PRCC PF10253.9 CCF46347.1 - 1.3e-39 137.3 6.7 1.3e-39 137.3 6.7 2.4 1 1 0 2 2 2 1 Mitotic checkpoint regulator, MAD2B-interacting HLH PF00010.26 CCF46348.1 - 0.039 13.9 0.1 0.12 12.3 0.1 1.8 1 0 0 1 1 1 0 Helix-loop-helix DNA-binding domain Vac_Fusion PF02346.16 CCF46349.1 - 0.13 11.9 0.2 0.21 11.2 0.2 1.3 1 0 0 1 1 1 0 Chordopoxvirus multifunctional envelope protein A27 Arginase PF00491.21 CCF46351.1 - 3.4e-06 26.8 0.0 3.7e-06 26.7 0.0 1.0 1 0 0 1 1 1 1 Arginase family RRM_1 PF00076.22 CCF46352.1 - 1.4e-14 53.6 0.0 1.8e-14 53.3 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 CCF46352.1 - 0.0025 17.8 0.0 0.0039 17.2 0.0 1.4 1 0 0 1 1 1 1 RNA binding motif HET PF06985.11 CCF46353.1 - 1.9e-35 122.3 0.2 3.4e-35 121.5 0.2 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) FtsJ PF01728.19 CCF46354.1 - 0.047 13.8 0.0 0.06 13.5 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase Med14 PF08638.11 CCF46354.1 - 0.16 11.4 0.0 0.21 11.0 0.0 1.2 1 0 0 1 1 1 0 Mediator complex subunit MED14 CRPA PF05745.11 CCF46356.1 - 0.27 11.2 0.6 0.85 9.6 0.0 1.9 2 0 0 2 2 2 0 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA) MBOAT PF03062.19 CCF46357.1 - 4.5e-57 194.0 3.6 9.5e-57 192.9 3.6 1.5 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family UAA PF08449.11 CCF46359.1 - 5.3e-08 32.4 11.7 6.6e-08 32.1 11.7 1.0 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 CCF46359.1 - 4.7e-05 23.6 19.8 7.8e-05 22.9 7.1 2.1 2 0 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 CCF46359.1 - 0.00034 20.1 4.6 0.00034 20.1 4.6 1.6 2 0 0 2 2 2 1 Triose-phosphate Transporter family PHO4 PF01384.20 CCF46359.1 - 0.24 10.4 12.4 0.15 11.1 10.1 2.0 1 1 0 1 1 1 0 Phosphate transporter family MFS_1 PF07690.16 CCF46362.1 - 9.9e-29 100.4 27.9 4.6e-28 98.2 28.1 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 CCF46362.1 - 0.0031 16.0 4.4 0.0038 15.7 4.4 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF3040 PF11239.8 CCF46362.1 - 0.038 14.2 0.2 0.038 14.2 0.2 4.0 4 2 0 4 4 4 0 Protein of unknown function (DUF3040) DUF4231 PF14015.6 CCF46362.1 - 0.55 10.7 2.0 5.2 7.6 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF4231) Cu-oxidase_3 PF07732.15 CCF46363.1 - 1.1e-41 141.5 1.6 1.8e-40 137.7 0.2 2.5 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase PF00394.22 CCF46363.1 - 1.4e-38 132.5 1.9 9.5e-35 120.1 0.0 3.4 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase_2 PF07731.14 CCF46363.1 - 7.6e-20 71.0 3.5 6.4e-14 51.9 0.1 3.8 3 1 0 3 3 3 2 Multicopper oxidase zf-RING_2 PF13639.6 CCF46364.1 - 4.2e-13 49.4 5.8 7.2e-13 48.6 5.8 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 CCF46364.1 - 1.5e-11 43.9 6.4 2.6e-11 43.2 6.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CCF46364.1 - 3.6e-10 39.6 3.5 5.9e-10 38.9 3.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CCF46364.1 - 5.3e-10 39.1 3.0 1.3e-09 37.9 3.1 1.6 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 CCF46364.1 - 2.8e-09 36.7 3.0 4.4e-09 36.1 3.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CCF46364.1 - 7.3e-08 32.2 3.9 1.3e-07 31.4 3.9 1.5 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 CCF46364.1 - 3.8e-07 29.9 6.9 5.5e-05 22.9 8.0 2.2 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 CCF46364.1 - 5.1e-07 29.7 5.1 1.2e-06 28.6 5.1 1.7 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.5 CCF46364.1 - 5.9e-06 25.9 1.9 1.1e-05 25.1 1.9 1.4 1 0 0 1 1 1 1 RING-like zinc finger zf-rbx1 PF12678.7 CCF46364.1 - 3e-05 24.2 9.5 0.00017 21.8 9.5 2.2 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 CCF46364.1 - 6e-05 23.0 0.8 8.8e-05 22.5 0.8 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger RskA PF10099.9 CCF46364.1 - 0.0065 16.8 0.1 0.007 16.7 0.1 1.2 1 0 0 1 1 1 1 Anti-sigma-K factor rskA C1_2 PF03107.16 CCF46364.1 - 0.011 16.1 5.2 0.04 14.2 5.2 1.9 1 1 0 1 1 1 0 C1 domain Vps39_2 PF10367.9 CCF46364.1 - 0.039 14.4 0.2 0.039 14.4 0.2 1.5 2 0 0 2 2 1 0 Vacuolar sorting protein 39 domain 2 zf-RING_4 PF14570.6 CCF46364.1 - 0.05 13.4 7.0 0.19 11.5 7.1 1.8 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain SLAC1 PF03595.17 CCF46364.1 - 0.074 12.3 0.0 0.091 12.0 0.0 1.1 1 0 0 1 1 1 0 Voltage-dependent anion channel Rad50_zn_hook PF04423.14 CCF46364.1 - 0.12 12.2 0.0 10 6.1 0.0 2.2 2 0 0 2 2 2 0 Rad50 zinc hook motif Zn_ribbon_17 PF17120.5 CCF46364.1 - 0.16 11.6 6.1 0.3 10.7 6.1 1.5 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type Zn-C2H2_12 PF18112.1 CCF46364.1 - 0.17 12.4 1.4 11 6.6 0.0 2.4 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain DZR PF12773.7 CCF46364.1 - 0.2 11.7 6.7 2.1 8.4 6.7 2.2 1 1 0 1 1 1 0 Double zinc ribbon TerY_C PF15616.6 CCF46364.1 - 0.21 11.7 2.8 0.37 10.9 2.8 1.4 1 0 0 1 1 1 0 TerY-C metal binding domain zf-RING_6 PF14835.6 CCF46364.1 - 0.46 10.4 7.0 1.3 8.9 7.0 1.7 1 1 0 1 1 1 0 zf-RING of BARD1-type protein FYVE PF01363.21 CCF46364.1 - 0.56 10.4 7.0 0.54 10.4 4.6 2.2 1 1 1 2 2 2 0 FYVE zinc finger Glyco_hydro_7 PF00840.20 CCF46365.1 - 2.8e-17 62.6 0.0 3.1e-17 62.4 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 7 DUF1833 PF08875.11 CCF46365.1 - 0.04 13.4 0.0 0.04 13.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1833) RRM_1 PF00076.22 CCF46366.1 - 1.5e-14 53.6 0.0 1.7e-12 46.9 0.0 2.3 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CCF46366.1 - 0.012 15.7 0.0 0.035 14.2 0.0 1.8 1 1 1 2 2 2 0 RNA recognition motif NACHT PF05729.12 CCF46368.1 - 4.2e-06 26.8 0.0 1.5e-05 25.0 0.0 2.0 1 1 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 CCF46368.1 - 0.0003 21.2 0.5 0.0051 17.2 0.0 3.0 3 0 0 3 3 3 1 AAA ATPase domain AAA_23 PF13476.6 CCF46368.1 - 0.00043 20.8 1.1 0.0045 17.5 0.0 2.3 2 0 0 2 2 2 1 AAA domain Helo_like_N PF17111.5 CCF46368.1 - 0.00085 18.7 1.3 0.0018 17.7 1.3 1.6 1 0 0 1 1 1 1 Fungal N-terminal domain of STAND proteins AAA_22 PF13401.6 CCF46368.1 - 0.0042 17.3 0.0 0.019 15.2 0.0 2.2 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CCF46368.1 - 0.0048 16.6 0.0 0.011 15.4 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.27 CCF46368.1 - 0.0057 17.2 0.0 0.017 15.6 0.0 1.7 1 0 0 1 1 1 1 ABC transporter T2SSF PF00482.23 CCF46368.1 - 0.015 15.2 6.0 0.33 10.9 3.0 3.7 3 0 0 3 3 3 0 Type II secretion system (T2SS), protein F AAA_18 PF13238.6 CCF46368.1 - 0.017 15.7 0.0 0.072 13.6 0.0 2.1 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 CCF46368.1 - 0.039 13.9 0.3 0.53 10.2 0.0 2.3 2 0 0 2 2 2 0 NTPase AAA_33 PF13671.6 CCF46368.1 - 0.055 13.6 0.1 0.21 11.7 0.1 2.0 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 CCF46368.1 - 0.062 13.4 0.0 0.24 11.5 0.0 2.0 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_28 PF13521.6 CCF46368.1 - 0.067 13.4 2.1 3.9 7.7 0.0 3.1 4 0 0 4 4 3 0 AAA domain RYDR_ITPR PF01365.21 CCF46368.1 - 0.096 12.1 1.1 0.89 8.9 0.0 2.8 3 0 0 3 3 3 0 RIH domain Synaptonemal_3 PF15191.6 CCF46368.1 - 0.097 12.5 0.6 0.45 10.3 0.1 2.3 2 0 0 2 2 2 0 Synaptonemal complex central element protein 3 RNA_helicase PF00910.22 CCF46368.1 - 0.14 12.6 0.1 0.37 11.2 0.1 1.7 1 0 0 1 1 1 0 RNA helicase p450 PF00067.22 CCF46370.1 - 1.9e-12 46.7 0.0 2.4e-12 46.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Methyltransf_2 PF00891.18 CCF46372.1 - 0.0002 20.7 0.0 0.056 12.7 0.0 2.4 1 1 1 2 2 2 2 O-methyltransferase domain Dimerisation PF08100.11 CCF46372.1 - 0.044 13.8 0.0 0.099 12.7 0.0 1.7 1 0 0 1 1 1 0 Dimerisation domain Adap_comp_sub PF00928.21 CCF46373.1 - 5.2e-69 232.6 0.0 6.4e-69 232.3 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 CCF46373.1 - 0.00032 20.6 0.0 0.0005 20.0 0.0 1.2 1 0 0 1 1 1 1 Clathrin adaptor complex small chain DUF1192 PF06698.11 CCF46374.1 - 0.092 12.8 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) AA_permease_2 PF13520.6 CCF46375.1 - 6e-10 38.5 3.3 6e-10 38.5 3.3 1.4 1 1 0 1 1 1 1 Amino acid permease DUF2053 PF09767.9 CCF46375.1 - 0.1 12.7 3.0 6.5 6.9 1.4 2.3 2 0 0 2 2 2 0 Predicted membrane protein (DUF2053) DUF2537 PF10801.8 CCF46375.1 - 0.6 10.4 5.8 0.23 11.7 2.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2537) Peptidase_U4 PF03419.13 CCF46375.1 - 1.7 7.9 5.3 6.7 5.9 5.3 1.8 1 1 0 1 1 1 0 Sporulation factor SpoIIGA Glyco_hydro_61 PF03443.14 CCF46377.1 - 9.5e-48 162.9 0.1 9.5e-48 162.9 0.1 1.5 2 0 0 2 2 2 1 Glycosyl hydrolase family 61 Transcript_VP30 PF11507.8 CCF46377.1 - 0.12 12.4 0.0 0.2 11.7 0.0 1.2 1 0 0 1 1 1 0 Ebola virus-specific transcription factor VP30 DUF4834 PF16118.5 CCF46377.1 - 0.25 12.3 2.4 0.66 11.0 2.4 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) PAP2 PF01569.21 CCF46378.1 - 2e-25 89.1 6.0 2.1e-25 89.1 1.7 2.2 2 0 0 2 2 2 1 PAP2 superfamily PAP2_C PF14360.6 CCF46378.1 - 0.92 10.1 7.4 0.15 12.6 1.9 2.4 2 1 0 2 2 2 0 PAP2 superfamily C-terminal Myb_DNA-bind_4 PF13837.6 CCF46379.1 - 0.0037 17.6 0.2 0.0071 16.7 0.2 1.5 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain NAM-associated PF14303.6 CCF46379.1 - 0.29 11.8 1.9 0.42 11.3 1.9 1.3 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain BCDHK_Adom3 PF10436.9 CCF46382.1 - 3.3e-46 157.1 0.0 4.5e-46 156.6 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase Inhibitor_I9 PF05922.16 CCF46383.1 - 5.3e-12 46.2 0.2 5.5e-12 46.2 0.2 1.0 1 0 0 1 1 1 1 Peptidase inhibitor I9 HET PF06985.11 CCF46386.1 - 2.6e-23 83.0 0.0 4.6e-23 82.2 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) HsbA PF12296.8 CCF46387.1 - 4.9e-08 33.4 3.3 8.9e-08 32.6 3.3 1.4 1 0 0 1 1 1 1 Hydrophobic surface binding protein A VIR_N PF15912.5 CCF46387.1 - 1.1 8.8 7.8 1.4 8.4 7.8 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal FAP PF07174.11 CCF46387.1 - 1.7 8.0 27.4 2.5 7.5 27.4 1.4 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) CCDC53 PF10152.9 CCF46387.1 - 9.8 6.6 8.9 19 5.6 8.9 1.7 1 1 0 1 1 1 0 Subunit CCDC53 of WASH complex DUF4129 PF13559.6 CCF46388.1 - 0.0039 17.4 0.9 0.0087 16.3 0.9 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4129) Inhibitor_Mig-6 PF11555.8 CCF46390.1 - 0.33 11.1 5.5 1.2 9.2 0.9 2.2 1 1 1 2 2 2 0 EGFR receptor inhibitor Mig-6 Glyco_transf_8 PF01501.20 CCF46392.1 - 5.4e-06 26.2 0.0 7.4e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 8 MFS_1 PF07690.16 CCF46393.1 - 5.8e-17 61.7 35.9 7.2e-17 61.3 35.9 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Maf PF02545.14 CCF46394.1 - 5.1e-50 169.6 0.0 6.1e-50 169.3 0.0 1.1 1 0 0 1 1 1 1 Maf-like protein Glyco_hydro_47 PF01532.20 CCF46395.1 - 1.2e-169 565.0 0.0 1.4e-169 564.8 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Utp11 PF03998.13 CCF46396.1 - 1.1e-65 222.1 17.4 1.2e-65 221.9 17.4 1.0 1 0 0 1 1 1 1 Utp11 protein SLATT_5 PF18160.1 CCF46396.1 - 1.1 8.5 5.1 0.1 11.9 0.5 1.6 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 DUF3246 PF11596.8 CCF46396.1 - 1.9 7.9 7.6 4.6 6.6 6.9 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3246) UPRTase PF14681.6 CCF46398.1 - 9.8e-42 142.7 0.1 1.3e-41 142.4 0.1 1.1 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 CCF46398.1 - 2.5e-06 27.1 2.1 0.0014 18.2 1.2 2.2 1 1 1 2 2 2 2 Phosphoribosyl transferase domain PRTase_2 PF15609.6 CCF46398.1 - 0.0021 17.6 0.0 0.0029 17.1 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase G-alpha PF00503.20 CCF46399.1 - 1e-54 186.1 0.2 1.2e-54 185.8 0.2 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 CCF46399.1 - 0.0033 16.9 0.2 0.0063 16.0 0.2 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family AAA_29 PF13555.6 CCF46399.1 - 0.0066 16.2 0.1 0.018 14.8 0.1 1.7 1 1 1 2 2 2 1 P-loop containing region of AAA domain MCM PF00493.23 CCF46399.1 - 0.024 13.7 0.1 0.045 12.8 0.1 1.5 1 1 0 1 1 1 0 MCM P-loop domain FtsK_SpoIIIE PF01580.18 CCF46399.1 - 0.056 12.8 0.1 0.13 11.6 0.0 1.5 2 0 0 2 2 2 0 FtsK/SpoIIIE family NB-ARC PF00931.22 CCF46399.1 - 0.083 12.1 0.1 0.11 11.6 0.1 1.2 1 0 0 1 1 1 0 NB-ARC domain Fe-S_biosyn PF01521.20 CCF46401.1 - 2.2e-12 47.2 0.0 1.5e-10 41.3 0.0 2.2 1 1 0 1 1 1 1 Iron-sulphur cluster biosynthesis KH_7 PF17214.3 CCF46401.1 - 0.0095 15.9 0.0 0.019 14.9 0.0 1.4 1 0 0 1 1 1 1 KH domain SDH_alpha PF03313.15 CCF46403.1 - 9.4e-73 245.1 0.0 1.2e-72 244.8 0.0 1.1 1 0 0 1 1 1 1 Serine dehydratase alpha chain SDH_beta PF03315.15 CCF46403.1 - 2.8e-07 31.0 0.2 9.2e-07 29.4 0.2 1.9 2 0 0 2 2 2 1 Serine dehydratase beta chain Ricin_B_lectin PF00652.22 CCF46404.1 - 2.4e-09 37.5 0.0 1e-05 25.8 0.0 2.3 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain API5 PF05918.11 CCF46404.1 - 6.8 5.4 4.8 9.2 4.9 4.8 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) AAA PF00004.29 CCF46405.1 - 4.5e-42 143.6 0.0 8.1e-42 142.8 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 CCF46405.1 - 2.9e-26 91.2 0.4 1.1e-25 89.4 0.2 2.2 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain MIT PF04212.18 CCF46405.1 - 3e-23 81.7 2.2 7.1e-23 80.4 2.2 1.7 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain RuvB_N PF05496.12 CCF46405.1 - 1.1e-06 28.5 0.0 1.8e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_lid_3 PF17862.1 CCF46405.1 - 1.2e-06 28.2 0.0 3.9e-06 26.6 0.0 1.8 1 0 0 1 1 1 1 AAA+ lid domain TIP49 PF06068.13 CCF46405.1 - 1.3e-05 24.6 0.0 3.2e-05 23.3 0.0 1.6 1 1 1 2 2 2 1 TIP49 P-loop domain AAA_16 PF13191.6 CCF46405.1 - 1.9e-05 25.1 0.0 0.0005 20.5 0.0 2.6 1 1 0 1 1 1 1 AAA ATPase domain IstB_IS21 PF01695.17 CCF46405.1 - 2.6e-05 24.1 0.0 5.1e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein RNA_helicase PF00910.22 CCF46405.1 - 3.9e-05 24.0 0.1 0.012 16.0 0.0 3.0 3 0 0 3 3 3 1 RNA helicase AAA_5 PF07728.14 CCF46405.1 - 6.6e-05 22.9 0.0 0.00034 20.6 0.0 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 CCF46405.1 - 0.00014 22.2 0.1 0.0087 16.3 0.1 2.6 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.6 CCF46405.1 - 0.00016 21.7 0.0 0.00044 20.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.13 CCF46405.1 - 0.00055 19.2 0.0 0.0064 15.7 0.0 2.1 1 1 1 2 2 2 1 Protein of unknown function (DUF815) AAA_18 PF13238.6 CCF46405.1 - 0.0008 20.0 0.0 0.0023 18.5 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 CCF46405.1 - 0.0025 17.6 0.0 0.0069 16.1 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 CCF46405.1 - 0.0029 17.8 0.0 0.0067 16.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_2 PF07724.14 CCF46405.1 - 0.0073 16.4 0.0 0.037 14.2 0.0 2.1 3 0 0 3 3 2 1 AAA domain (Cdc48 subfamily) AAA_17 PF13207.6 CCF46405.1 - 0.0092 16.4 0.0 0.049 14.1 0.0 2.2 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 CCF46405.1 - 0.02 14.8 0.0 0.71 9.8 0.0 2.3 1 1 1 2 2 2 0 NACHT domain AAA_7 PF12775.7 CCF46405.1 - 0.023 14.2 0.1 0.12 11.9 0.0 2.3 3 1 0 3 3 2 0 P-loop containing dynein motor region AAA_25 PF13481.6 CCF46405.1 - 0.027 14.0 0.1 0.36 10.4 0.1 2.3 1 1 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 CCF46405.1 - 0.028 13.8 0.0 0.081 12.3 0.0 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI USP8_dimer PF08969.11 CCF46405.1 - 0.039 14.1 1.4 0.077 13.2 1.4 1.5 1 0 0 1 1 1 0 USP8 dimerisation domain AAA_21 PF13304.6 CCF46405.1 - 0.069 12.9 0.1 8.2 6.1 0.0 2.4 1 1 1 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system PhoH PF02562.16 CCF46405.1 - 0.072 12.5 0.1 0.15 11.5 0.1 1.5 1 0 0 1 1 1 0 PhoH-like protein Torsin PF06309.11 CCF46405.1 - 0.089 12.9 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 Torsin Bac_DnaA PF00308.18 CCF46405.1 - 0.1 12.4 0.0 0.34 10.7 0.0 1.8 1 1 0 1 1 1 0 Bacterial dnaA protein Parvo_NS1 PF01057.17 CCF46405.1 - 0.11 11.6 0.0 0.18 10.9 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 ATPase PF06745.13 CCF46405.1 - 0.12 11.7 0.0 5.6 6.2 0.0 2.5 1 1 1 2 2 2 0 KaiC Cytidylate_kin PF02224.18 CCF46405.1 - 0.13 12.0 0.3 0.53 10.0 0.1 2.1 3 0 0 3 3 2 0 Cytidylate kinase Sigma54_activat PF00158.26 CCF46405.1 - 0.14 11.9 0.0 0.42 10.3 0.0 1.8 1 1 0 1 1 1 0 Sigma-54 interaction domain Prefoldin_2 PF01920.20 CCF46406.1 - 7.1e-19 67.7 13.1 9.4e-19 67.3 13.1 1.2 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin_3 PF13758.6 CCF46406.1 - 0.037 14.1 4.4 0.052 13.6 4.4 1.3 1 0 0 1 1 1 0 Prefoldin subunit JIP_LZII PF16471.5 CCF46406.1 - 0.049 13.8 3.3 0.049 13.8 3.3 2.1 2 2 0 2 2 2 0 JNK-interacting protein leucine zipper II Herpes_BLRF2 PF05812.12 CCF46406.1 - 0.07 13.3 4.3 0.13 12.4 4.3 1.5 1 1 0 1 1 1 0 Herpesvirus BLRF2 protein DUF1732 PF08340.11 CCF46406.1 - 0.078 13.0 2.8 1.9 8.5 0.1 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF1732) Prefoldin PF02996.17 CCF46406.1 - 0.2 11.6 10.7 1.2 9.1 0.3 2.8 1 1 2 3 3 3 0 Prefoldin subunit Spc7 PF08317.11 CCF46406.1 - 0.29 10.0 14.6 1.5 7.6 14.6 1.8 1 1 0 1 1 1 0 Spc7 kinetochore protein ERp29 PF07749.12 CCF46406.1 - 0.41 11.6 5.5 3 8.8 5.5 2.2 1 1 0 1 1 1 0 Endoplasmic reticulum protein ERp29, C-terminal domain DUF4407 PF14362.6 CCF46406.1 - 1.3 8.3 8.4 2 7.7 8.4 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) PHM7_cyt PF14703.6 CCF46406.1 - 2 8.6 5.9 4.8 7.4 5.9 1.7 1 1 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter Spc24 PF08286.11 CCF46406.1 - 4.4 7.6 11.8 2.1 8.6 6.2 2.1 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 FlaC_arch PF05377.11 CCF46406.1 - 6 7.3 7.0 3.3 8.2 1.5 2.7 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) ZapB PF06005.12 CCF46406.1 - 6.2 7.3 15.7 12 6.4 15.7 1.8 1 1 0 1 1 1 0 Cell division protein ZapB Cep57_MT_bd PF06657.13 CCF46406.1 - 7.9 7.0 12.4 4.6 7.8 6.1 2.9 2 2 1 3 3 3 0 Centrosome microtubule-binding domain of Cep57 DivIC PF04977.15 CCF46406.1 - 8.9 6.2 19.0 12 5.8 11.6 3.3 2 2 0 2 2 2 0 Septum formation initiator JAB PF01398.21 CCF46408.1 - 3.1e-14 53.0 0.0 5.8e-14 52.1 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease USP8_dimer PF08969.11 CCF46408.1 - 1.8e-05 24.9 0.0 4.4e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 USP8 dimerisation domain Prok-JAB PF14464.6 CCF46408.1 - 2.1e-05 24.3 0.1 6.2e-05 22.8 0.0 1.8 2 0 0 2 2 2 1 Prokaryotic homologs of the JAB domain DUF5429 PF17494.2 CCF46409.1 - 1.8 8.6 4.4 0.49 10.5 0.7 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5429) dCMP_cyt_deam_1 PF00383.23 CCF46410.1 - 1.2e-09 37.9 0.0 2.3e-09 37.1 0.0 1.4 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 CCF46410.1 - 9.8e-05 22.1 0.0 0.0012 18.6 0.0 2.0 1 1 0 1 1 1 1 MafB19-like deaminase Cwf_Cwc_15 PF04889.12 CCF46410.1 - 0.47 10.1 1.2 0.63 9.7 1.2 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Bd3614-deam PF14439.6 CCF46410.1 - 1.7 8.7 7.8 0.64 10.1 1.8 2.6 2 1 0 2 2 2 0 Bd3614-like deaminase DUF1173 PF06666.11 CCF46411.1 - 0.093 11.6 0.5 0.092 11.7 0.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1173) PAS_4 PF08448.10 CCF46412.1 - 0.0011 19.2 0.7 0.14 12.4 0.0 2.6 3 0 0 3 3 3 2 PAS fold Antimicrobial23 PF16048.5 CCF46413.1 - 0.0096 15.6 0.5 0.015 14.9 0.5 1.3 1 0 0 1 1 1 1 Frog antimicrobial peptide HisKA PF00512.25 CCF46414.1 - 4.4e-10 39.5 0.2 1e-09 38.3 0.2 1.6 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain KR PF08659.10 CCF46414.1 - 0.16 11.9 0.2 0.62 9.9 0.1 1.9 1 1 1 2 2 2 0 KR domain Pec_lyase_C PF00544.19 CCF46415.1 - 1.3e-11 44.5 4.9 6.2e-10 39.0 4.9 2.2 1 1 0 1 1 1 1 Pectate lyase Beta_helix PF13229.6 CCF46415.1 - 9e-05 22.4 6.8 0.001 18.9 6.0 2.2 1 1 0 1 1 1 1 Right handed beta helix region Zn_clus PF00172.18 CCF46417.1 - 1e-08 35.1 11.9 1.4e-08 34.7 11.9 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Dickkopf_N PF04706.12 CCF46417.1 - 1.9 9.1 11.7 2.6 8.6 2.3 2.2 1 1 1 2 2 2 0 Dickkopf N-terminal cysteine-rich region Fn3-like PF14310.6 CCF46419.1 - 6.2e-23 80.7 0.2 9.3e-23 80.1 0.2 1.3 1 0 0 1 1 1 1 Fibronectin type III-like domain D-ser_dehydrat PF14031.6 CCF46420.1 - 1e-20 74.2 0.0 2.7e-20 72.8 0.0 1.7 1 0 0 1 1 1 1 Putative serine dehydratase domain Ala_racemase_N PF01168.20 CCF46420.1 - 3.8e-15 56.1 0.5 5.1e-15 55.7 0.5 1.3 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain tRNA_SAD PF07973.14 CCF46421.1 - 1.7e-08 34.5 1.3 3.3e-08 33.5 1.3 1.6 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain PH_8 PF15409.6 CCF46421.1 - 0.035 14.4 0.1 0.078 13.3 0.1 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain Aa_trans PF01490.18 CCF46422.1 - 1.7e-43 148.9 33.6 1.9e-43 148.7 33.6 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 CCF46422.1 - 0.00014 21.0 15.6 0.00014 21.0 15.6 1.7 2 0 0 2 2 2 1 Tryptophan/tyrosine permease family CAAD PF14159.6 CCF46422.1 - 0.014 15.3 3.3 0.017 14.9 0.5 2.8 2 0 0 2 2 2 0 CAAD domains of cyanobacterial aminoacyl-tRNA synthetase p450 PF00067.22 CCF46423.1 - 2.7e-54 184.7 0.0 3.4e-54 184.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Peptidase_S10 PF00450.22 CCF46424.1 - 4.2e-66 224.1 0.0 6.1e-66 223.5 0.0 1.2 1 0 0 1 1 1 1 Serine carboxypeptidase Methyltransf_23 PF13489.6 CCF46425.1 - 1.2e-23 83.8 0.0 1.7e-23 83.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF46425.1 - 8.4e-11 42.4 0.0 1.6e-10 41.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF46425.1 - 3.2e-10 40.0 0.0 2.5e-09 37.1 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF46425.1 - 3.3e-07 30.9 0.0 7e-07 29.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF46425.1 - 1.6e-06 28.8 0.0 1.1e-05 26.1 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CCF46425.1 - 0.00095 18.8 0.0 0.0022 17.5 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase small domain Ubie_methyltran PF01209.18 CCF46425.1 - 0.0012 18.2 0.0 0.023 14.0 0.0 2.5 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 CCF46425.1 - 0.0025 17.3 0.0 0.0051 16.3 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase PrmA PF06325.13 CCF46425.1 - 0.0034 16.8 0.0 0.0063 15.9 0.0 1.5 1 1 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) FtsJ PF01728.19 CCF46425.1 - 0.015 15.4 0.0 0.027 14.6 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase UDPG_MGDP_dh PF00984.19 CCF46427.1 - 5e-20 71.5 0.0 9.8e-20 70.6 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_N PF03721.14 CCF46427.1 - 8e-15 54.9 0.0 6.8e-13 48.6 0.0 2.3 1 1 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh_C PF03720.15 CCF46427.1 - 0.0022 18.4 0.0 0.0055 17.1 0.0 1.6 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain TrkA_N PF02254.18 CCF46427.1 - 0.0037 17.5 0.0 0.014 15.6 0.0 2.0 2 0 0 2 2 2 1 TrkA-N domain F420_oxidored PF03807.17 CCF46427.1 - 0.088 13.4 0.0 0.87 10.2 0.0 2.4 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Chitin_synth_2 PF03142.15 CCF46428.1 - 8.8e-31 107.1 0.0 4.7e-26 91.5 0.0 2.3 2 0 0 2 2 2 2 Chitin synthase Glyco_tranf_2_3 PF13641.6 CCF46428.1 - 9.8e-07 28.9 0.9 1.9e-06 27.9 0.4 1.7 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 CCF46428.1 - 5e-05 23.3 1.7 0.00011 22.2 1.7 1.6 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 CCF46428.1 - 0.00011 22.0 0.0 0.71 9.7 0.0 2.6 3 0 0 3 3 3 2 Glycosyl transferase family 2 Methyltransf_23 PF13489.6 CCF46429.1 - 8.6e-20 71.2 0.0 1.2e-19 70.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF46429.1 - 9.4e-12 45.5 0.0 2.2e-11 44.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF46429.1 - 7.4e-11 42.1 0.0 1.1e-09 38.3 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF46429.1 - 2.5e-08 34.4 0.0 5.6e-08 33.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF46429.1 - 2.9e-05 24.7 0.0 8.2e-05 23.3 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CCF46429.1 - 0.0011 18.5 0.0 0.0018 17.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_16 PF10294.9 CCF46429.1 - 0.0024 17.6 0.0 0.0053 16.5 0.0 1.6 1 0 0 1 1 1 1 Lysine methyltransferase PrmA PF06325.13 CCF46429.1 - 0.0096 15.3 0.0 0.015 14.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) FtsJ PF01728.19 CCF46429.1 - 0.019 15.1 0.0 0.04 14.0 0.0 1.5 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_4 PF02390.17 CCF46429.1 - 0.02 14.3 0.0 0.047 13.1 0.0 1.6 1 0 0 1 1 1 0 Putative methyltransferase CMAS PF02353.20 CCF46429.1 - 0.021 14.1 0.0 0.04 13.2 0.0 1.5 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_2 PF00891.18 CCF46429.1 - 0.072 12.4 0.0 0.19 11.0 0.0 1.6 1 0 0 1 1 1 0 O-methyltransferase domain Vwaint PF14624.6 CCF46430.1 - 4.4e-31 106.8 0.0 8e-31 106.0 0.0 1.4 1 0 0 1 1 1 1 VWA / Hh protein intein-like VWA PF00092.28 CCF46430.1 - 1.5e-07 31.8 0.0 2.9e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 CCF46430.1 - 1.1e-06 28.6 0.0 2.7e-06 27.4 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 CCF46430.1 - 0.00098 19.8 0.0 0.002 18.7 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain CLZ PF16526.5 CCF46432.1 - 0.3 11.5 7.8 0.79 10.1 2.2 2.8 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Cwf_Cwc_15 PF04889.12 CCF46434.1 - 0.00042 20.1 2.6 0.00048 20.0 2.6 1.0 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein Tho1_MOS11_C PF18592.1 CCF46434.1 - 0.015 15.1 2.1 1.5 8.7 0.2 2.3 2 0 0 2 2 2 0 Tho1/MOS11 C-terminal domain TolA_bind_tri PF16331.5 CCF46434.1 - 0.022 14.8 3.5 0.028 14.5 3.5 1.2 1 0 0 1 1 1 0 TolA binding protein trimerisation SKA2 PF16740.5 CCF46434.1 - 0.028 14.2 3.8 0.036 13.9 3.8 1.1 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 2 Herpes_UL17 PF04559.12 CCF46434.1 - 0.12 11.1 2.3 0.13 11.0 2.3 1.0 1 0 0 1 1 1 0 Herpesvirus UL17 protein Egh16-like PF11327.8 CCF46437.1 - 5.8e-28 98.6 7.9 2e-27 96.8 7.9 1.8 1 1 0 1 1 1 1 Egh16-like virulence factor Izumo-Ig PF16706.5 CCF46437.1 - 0.13 12.3 0.0 0.24 11.5 0.0 1.4 1 0 0 1 1 1 0 Izumo-like Immunoglobulin domain DUF3716 PF12511.8 CCF46437.1 - 0.13 12.3 1.2 0.26 11.4 1.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3716) MFS_1 PF07690.16 CCF46438.1 - 4.6e-45 154.1 30.9 6.9e-45 153.5 30.9 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF46438.1 - 2.5e-12 46.4 9.8 2.5e-12 46.4 9.8 2.0 3 0 0 3 3 3 1 Sugar (and other) transporter MFS_4 PF06779.14 CCF46438.1 - 0.0035 16.7 7.0 0.0035 16.7 7.0 2.6 2 2 1 3 3 3 1 Uncharacterised MFS-type transporter YbfB Gly-zipper_Omp PF13488.6 CCF46438.1 - 0.68 10.0 6.9 2.4 8.2 1.8 2.8 2 0 0 2 2 2 0 Glycine zipper OATP PF03137.20 CCF46438.1 - 3.1 6.0 8.9 0.15 10.4 1.7 2.3 3 0 0 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family DUF3752 PF12572.8 CCF46439.1 - 0.93 10.0 7.3 8.8 6.8 7.3 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3752) p450 PF00067.22 CCF46441.1 - 2.7e-61 207.7 0.0 4.1e-61 207.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Pro_Al_protease PF02983.14 CCF46442.1 - 9.4e-13 48.0 2.4 9.4e-13 48.0 2.4 2.2 3 0 0 3 3 3 1 Alpha-lytic protease prodomain Csm4_C PF17953.1 CCF46443.1 - 0.15 11.9 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 CRISPR Csm4 C-terminal domain HTH_15 PF12324.8 CCF46444.1 - 0.013 15.4 1.1 0.049 13.6 0.9 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain of alkylmercury lyase Cupin_1 PF00190.22 CCF46446.1 - 6.5e-16 58.3 1.0 1e-15 57.6 1.0 1.2 1 0 0 1 1 1 1 Cupin Cupin_2 PF07883.11 CCF46446.1 - 0.014 15.1 0.0 0.028 14.1 0.0 1.5 1 0 0 1 1 1 0 Cupin domain adh_short PF00106.25 CCF46447.1 - 6.2e-36 123.7 0.0 8.6e-36 123.2 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF46447.1 - 2.8e-30 105.6 0.0 3.6e-30 105.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF46447.1 - 2.1e-09 37.5 0.0 8.9e-09 35.5 0.0 1.8 2 0 0 2 2 2 1 KR domain Polysacc_synt_2 PF02719.15 CCF46447.1 - 0.0041 16.3 0.0 0.0066 15.6 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 CCF46447.1 - 0.061 12.8 0.0 0.19 11.2 0.0 1.7 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family Condensation PF00668.20 CCF46448.1 - 1.1e-08 34.2 0.0 1.4e-08 33.9 0.0 1.1 1 0 0 1 1 1 1 Condensation domain ketoacyl-synt PF00109.26 CCF46449.1 - 6.9e-26 91.3 0.0 8.2e-26 91.1 0.0 1.0 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain MFS_1 PF07690.16 CCF46451.1 - 2.3e-24 86.0 30.6 3e-24 85.6 30.6 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily RGS PF00615.19 CCF46453.1 - 8.4e-11 42.2 0.0 1.1e-10 41.8 0.0 1.1 1 0 0 1 1 1 1 Regulator of G protein signaling domain Sugar_tr PF00083.24 CCF46455.1 - 0.0001 21.3 5.1 0.00012 21.1 5.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF46455.1 - 0.00048 19.2 4.3 0.00064 18.7 4.3 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Trp_oprn_chp PF09534.10 CCF46455.1 - 0.018 14.8 1.9 0.024 14.4 1.9 1.2 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) ANAPC4_WD40 PF12894.7 CCF46457.1 - 3.2e-05 24.1 0.1 0.019 15.3 0.0 3.5 3 1 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CCF46457.1 - 0.019 15.8 0.3 0.019 15.8 0.3 3.8 5 0 0 5 5 5 0 WD domain, G-beta repeat CzcE PF16986.5 CCF46457.1 - 0.02 15.2 0.3 0.061 13.7 0.2 1.8 2 0 0 2 2 2 0 Heavy-metal resistance protein CzcE ADH_N PF08240.12 CCF46458.1 - 7.7e-25 86.9 3.0 1.5e-24 85.9 3.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCF46458.1 - 1.5e-16 60.5 0.0 2.3e-16 60.0 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCF46458.1 - 0.018 16.1 0.0 0.034 15.2 0.0 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 CCF46458.1 - 0.044 13.1 0.0 0.088 12.1 0.0 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain ELFV_dehydrog PF00208.21 CCF46458.1 - 0.045 13.5 0.3 0.077 12.7 0.3 1.3 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Wzy_C PF04932.15 CCF46459.1 - 3.2 7.4 8.5 6.1 6.5 0.0 3.0 1 1 2 3 3 3 0 O-Antigen ligase Wzy_C_2 PF11846.8 CCF46460.1 - 0.11 12.5 0.0 0.12 12.3 0.0 1.0 1 0 0 1 1 1 0 Virulence factor membrane-bound polymerase, C-terminal p450 PF00067.22 CCF46463.1 - 4.8e-36 124.5 0.0 6e-36 124.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Ribosomal_L19 PF01245.20 CCF46464.1 - 4.2e-11 42.7 0.0 6.7e-11 42.1 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L19 Alpha-amylase PF00128.24 CCF46465.1 - 2.5e-16 60.2 8.8 4.4e-16 59.4 8.8 1.3 1 1 0 1 1 1 1 Alpha amylase, catalytic domain DUF3048_C PF17479.2 CCF46465.1 - 0.023 15.1 1.2 0.044 14.2 1.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3048) C-terminal domain DUF3606 PF12244.8 CCF46465.1 - 0.062 13.2 0.1 0.14 12.1 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3606) Skp1_POZ PF03931.15 CCF46468.1 - 2.3e-08 34.1 0.0 3.1e-08 33.7 0.0 1.2 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain DEAD PF00270.29 CCF46469.1 - 5.8e-46 156.5 0.0 1.1e-45 155.6 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF46469.1 - 1.2e-22 80.4 0.0 8.9e-22 77.5 0.0 2.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 CCF46469.1 - 6.8e-19 67.9 0.2 1.4e-18 66.9 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 CCF46469.1 - 6e-05 23.1 0.0 0.00019 21.5 0.0 1.9 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 CCF46469.1 - 0.001 18.3 0.0 0.001 18.3 0.0 1.6 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase 6PF2K PF01591.18 CCF46471.1 - 1.1e-79 266.9 0.2 1.6e-79 266.3 0.2 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 CCF46471.1 - 1.8e-34 119.1 0.0 2.9e-34 118.4 0.0 1.4 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 CCF46471.1 - 1.9e-06 28.1 0.0 3.4e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 CCF46471.1 - 9.2e-05 22.0 0.1 0.00014 21.4 0.1 1.3 1 0 0 1 1 1 1 Chromatin associated protein KTI12 Glyco_hydro_26 PF02156.15 CCF46471.1 - 0.071 12.5 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 26 Adeno_E3_CR1 PF02440.15 CCF46471.1 - 0.14 12.0 0.1 0.33 10.8 0.0 1.6 1 1 0 1 1 1 0 Adenovirus E3 region protein CR1 Asp PF00026.23 CCF46472.1 - 8.2e-37 127.3 0.1 1.1e-36 126.9 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.6 CCF46472.1 - 6.7e-07 29.9 0.1 0.0077 16.9 0.1 3.3 3 0 0 3 3 3 2 Aspartyl protease gag-asp_proteas PF13975.6 CCF46472.1 - 0.0043 17.6 0.1 0.95 10.1 0.1 3.0 3 0 0 3 3 3 1 gag-polyprotein putative aspartyl protease TAXi_C PF14541.6 CCF46472.1 - 0.018 14.8 0.0 0.29 10.9 0.0 2.6 2 1 0 2 2 2 0 Xylanase inhibitor C-terminal TAXi_N PF14543.6 CCF46472.1 - 0.029 14.6 0.5 1.1 9.4 0.5 2.9 2 1 0 2 2 2 0 Xylanase inhibitor N-terminal Helicase_C PF00271.31 CCF46475.1 - 0.0084 16.4 0.0 0.026 14.9 0.0 1.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Lipase_3 PF01764.25 CCF46476.1 - 3.3e-21 75.7 0.1 4.6e-21 75.2 0.1 1.2 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.7 CCF46476.1 - 0.0035 18.0 1.2 0.0037 17.9 1.1 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Thioesterase PF00975.20 CCF46476.1 - 0.025 14.7 0.0 0.042 14.0 0.0 1.3 1 0 0 1 1 1 0 Thioesterase domain Abhydrolase_8 PF06259.12 CCF46476.1 - 0.037 13.7 0.0 0.055 13.1 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase Hydrolase_4 PF12146.8 CCF46476.1 - 0.094 12.0 0.0 0.13 11.5 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 ETF_QO PF05187.13 CCF46477.1 - 1e-48 163.8 0.6 1.6e-48 163.1 0.6 1.3 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S DAO PF01266.24 CCF46477.1 - 0.026 14.1 0.0 0.053 13.1 0.0 1.5 2 0 0 2 2 2 0 FAD dependent oxidoreductase Fer4_7 PF12838.7 CCF46477.1 - 0.028 15.0 0.8 0.076 13.6 0.8 1.7 1 0 0 1 1 1 0 4Fe-4S dicluster domain Fer4_2 PF12797.7 CCF46477.1 - 0.11 12.7 0.7 0.3 11.3 0.7 1.7 1 0 0 1 1 1 0 4Fe-4S binding domain HIG_1_N PF04588.13 CCF46481.1 - 6.2e-06 26.3 2.2 1.6e-05 25.0 2.2 1.6 1 0 0 1 1 1 1 Hypoxia induced protein conserved region ubiquitin PF00240.23 CCF46482.1 - 2e-19 69.1 0.0 2.6e-19 68.7 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 CCF46482.1 - 7.8e-05 22.4 0.1 9.5e-05 22.2 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.6 CCF46482.1 - 8.9e-05 22.6 0.0 0.00011 22.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 CCF46482.1 - 0.0026 18.3 0.0 0.0031 18.1 0.0 1.1 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain CDP-OH_P_transf PF01066.21 CCF46484.1 - 1.5e-14 54.5 0.4 3.7e-14 53.3 0.4 1.7 1 0 0 1 1 1 1 CDP-alcohol phosphatidyltransferase RMI1_N PF08585.12 CCF46485.1 - 7.6e-55 186.0 0.0 8.7e-55 185.8 0.0 1.0 1 0 0 1 1 1 1 RecQ mediated genome instability protein Dynamin_N PF00350.23 CCF46490.1 - 3.8e-31 108.4 0.0 7.6e-31 107.4 0.0 1.5 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 CCF46490.1 - 2.1e-23 83.0 0.0 5.8e-23 81.5 0.0 1.8 1 0 0 1 1 1 1 Dynamin central region GED PF02212.18 CCF46490.1 - 4.8e-06 26.6 0.6 1.6e-05 24.9 0.6 1.9 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 CCF46490.1 - 2.6e-05 24.3 0.0 0.12 12.4 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_15 PF13175.6 CCF46490.1 - 0.041 13.6 0.0 0.11 12.2 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain Ras PF00071.22 CCF46490.1 - 0.15 11.6 0.0 6 6.4 0.0 2.5 2 0 0 2 2 2 0 Ras family CN_hydrolase PF00795.22 CCF46491.1 - 2.2e-40 138.7 0.0 4.5e-40 137.6 0.0 1.5 1 1 0 1 1 1 1 Carbon-nitrogen hydrolase CAV_VP3 PF04771.12 CCF46492.1 - 0.0083 16.3 0.0 0.0088 16.2 0.0 1.1 1 0 0 1 1 1 1 Chicken anaemia virus VP-3 protein HET PF06985.11 CCF46494.1 - 5.9e-24 85.1 0.0 9.8e-24 84.4 0.0 1.3 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) TFIIA PF03153.13 CCF46496.1 - 0.058 13.4 25.7 0.099 12.6 25.7 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Cys_Met_Meta_PP PF01053.20 CCF46499.1 - 3e-142 473.7 0.0 3.5e-142 473.5 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 CCF46499.1 - 8e-09 35.1 0.1 1.1e-08 34.6 0.1 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 CCF46499.1 - 3.8e-08 33.0 0.0 1.1e-07 31.6 0.0 1.6 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 CCF46499.1 - 3.9e-08 32.7 0.2 6.4e-08 32.0 0.2 1.4 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 CCF46499.1 - 0.00011 21.6 0.1 0.00024 20.5 0.1 1.6 1 1 0 1 1 1 1 Beta-eliminating lyase SepSecS PF05889.13 CCF46499.1 - 0.0033 16.2 0.1 0.0048 15.6 0.1 1.1 1 0 0 1 1 1 1 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Met_gamma_lyase PF06838.11 CCF46499.1 - 0.016 13.7 0.0 0.021 13.3 0.0 1.2 1 0 0 1 1 1 0 Methionine gamma-lyase BRK PF07533.16 CCF46499.1 - 0.023 14.3 1.1 0.39 10.4 0.3 2.4 2 0 0 2 2 2 0 BRK domain ADH_zinc_N PF00107.26 CCF46499.1 - 0.041 13.9 0.0 0.15 12.1 0.0 1.9 2 0 0 2 2 2 0 Zinc-binding dehydrogenase GDC-P PF02347.16 CCF46499.1 - 0.1 11.4 0.0 0.14 11.0 0.0 1.1 1 0 0 1 1 1 0 Glycine cleavage system P-protein Cerato-platanin PF07249.12 CCF46501.1 - 2.8e-32 111.3 0.2 3e-32 111.2 0.2 1.0 1 0 0 1 1 1 1 Cerato-platanin Glyco_hydro_18 PF00704.28 CCF46502.1 - 3.6e-67 227.3 0.0 4.1e-67 227.1 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 DUF3142 PF11340.8 CCF46502.1 - 0.023 14.5 0.0 0.037 13.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3142) Hamartin PF04388.12 CCF46503.1 - 3 6.4 16.7 3.9 6.0 16.7 1.1 1 0 0 1 1 1 0 Hamartin protein zf-UBR PF02207.20 CCF46504.1 - 5.9e-15 55.2 4.7 8.7e-15 54.6 4.7 1.3 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) NSP10 PF09401.10 CCF46504.1 - 0.017 15.2 0.2 0.026 14.6 0.2 1.3 1 0 0 1 1 1 0 RNA synthesis protein NSP10 DHODB_Fe-S_bind PF10418.9 CCF46504.1 - 0.14 12.0 6.8 0.16 11.8 4.4 2.1 2 0 0 2 2 2 0 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B PH_10 PF15411.6 CCF46505.1 - 3.1e-29 101.7 0.3 5.3e-29 101.0 0.3 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain VWA PF00092.28 CCF46505.1 - 5.6e-14 52.8 0.0 9e-14 52.1 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 CCF46505.1 - 1.3e-09 38.2 0.1 4.7e-09 36.4 0.1 1.9 1 1 0 1 1 1 1 von Willebrand factor type A domain zf-RING_2 PF13639.6 CCF46505.1 - 0.0016 18.7 5.6 0.0028 17.9 5.6 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 CCF46505.1 - 0.0076 16.2 5.5 0.013 15.5 5.5 1.4 1 0 0 1 1 1 1 zinc-RING finger domain PH PF00169.29 CCF46505.1 - 0.016 15.7 0.0 0.035 14.6 0.0 1.5 1 0 0 1 1 1 0 PH domain zf-RING-like PF08746.11 CCF46505.1 - 0.065 13.6 4.2 0.11 12.8 4.2 1.4 1 0 0 1 1 1 0 RING-like domain Regulator_TrmB PF11495.8 CCF46505.1 - 0.074 12.2 0.0 0.22 10.7 0.0 1.7 2 0 0 2 2 2 0 Archaeal transcriptional regulator TrmB zf-rbx1 PF12678.7 CCF46505.1 - 0.098 13.0 2.9 0.22 11.9 2.9 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain Zn_ribbon_17 PF17120.5 CCF46505.1 - 0.1 12.2 7.2 0.02 14.5 3.5 1.6 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type zf-C3HC4_2 PF13923.6 CCF46505.1 - 0.11 12.3 4.8 0.21 11.5 4.8 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 CCF46505.1 - 0.14 11.9 4.7 0.31 10.8 4.7 1.6 1 0 0 1 1 1 0 RING-like zinc finger zf-C3HC4 PF00097.25 CCF46505.1 - 0.15 11.9 5.5 0.28 11.1 5.5 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF1147 PF06615.11 CCF46505.1 - 0.17 12.0 0.5 0.43 10.6 0.5 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1147) zf-C3H2C3 PF17122.5 CCF46505.1 - 2.7 8.1 5.1 5.9 7.0 5.1 1.6 1 0 0 1 1 1 0 Zinc-finger HET PF06985.11 CCF46506.1 - 9.3e-10 39.0 0.0 1.4e-09 38.5 0.0 1.2 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Fungal_trans PF04082.18 CCF46511.1 - 0.00027 20.1 0.1 0.00057 19.0 0.1 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain Condensation PF00668.20 CCF46512.1 - 4.7e-16 58.5 0.0 7.5e-16 57.8 0.0 1.2 1 0 0 1 1 1 1 Condensation domain PP-binding PF00550.25 CCF46512.1 - 5.4e-06 26.7 0.0 1.1e-05 25.7 0.0 1.5 1 0 0 1 1 1 1 Phosphopantetheine attachment site AMP-binding_C PF13193.6 CCF46512.1 - 0.011 16.7 0.0 0.05 14.6 0.0 2.1 2 1 0 2 2 2 0 AMP-binding enzyme C-terminal domain Period_C PF12114.8 CCF46512.1 - 3.4 7.2 9.3 8.2 6.0 9.3 1.6 1 0 0 1 1 1 0 Period protein 2/3C-terminal region YEATS PF03366.16 CCF46513.1 - 1.2e-22 79.6 0.1 2.2e-22 78.8 0.1 1.4 1 0 0 1 1 1 1 YEATS family BET PF17035.5 CCF46513.1 - 0.0011 19.1 0.4 0.0037 17.4 0.1 2.0 2 0 0 2 2 2 1 Bromodomain extra-terminal - transcription regulation p25-alpha PF05517.12 CCF46513.1 - 0.0057 16.8 0.4 0.065 13.4 0.4 2.4 2 1 0 2 2 2 1 p25-alpha MgtE_N PF03448.17 CCF46513.1 - 0.056 14.1 0.1 0.11 13.1 0.1 1.5 1 0 0 1 1 1 0 MgtE intracellular N domain DUF3791 PF12668.7 CCF46513.1 - 0.12 12.4 0.0 0.38 10.8 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3791) DUF953 PF06110.11 CCF46515.1 - 4.9e-19 68.1 0.1 5.9e-19 67.8 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF953) Thioredoxin PF00085.20 CCF46515.1 - 0.0067 16.4 0.1 0.013 15.4 0.1 1.6 1 1 0 1 1 1 1 Thioredoxin Thioredoxin_9 PF14595.6 CCF46515.1 - 0.13 12.1 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin Vac7 PF12751.7 CCF46516.1 - 4.1e-156 520.2 4.0 4.1e-156 520.2 4.0 1.8 2 0 0 2 2 2 1 Vacuolar segregation subunit 7 MWFE PF15879.5 CCF46518.1 - 0.48 10.6 2.7 0.35 11.1 0.5 2.0 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase MWFE subunit DUF3915 PF13054.6 CCF46518.1 - 1.1 9.2 8.2 0.19 11.7 4.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) CDC45 PF02724.14 CCF46519.1 - 0.17 10.1 19.3 0.018 13.4 13.0 2.0 2 0 0 2 2 2 0 CDC45-like protein Nop14 PF04147.12 CCF46519.1 - 1 7.5 25.9 0.015 13.5 18.0 1.7 2 0 0 2 2 2 0 Nop14-like family DNA_pol_phi PF04931.13 CCF46519.1 - 2.7 6.0 24.6 5 5.1 24.6 1.4 1 0 0 1 1 1 0 DNA polymerase phi Dioxygenase_C PF00775.21 CCF46520.1 - 9.2e-09 35.0 0.0 1.5e-08 34.3 0.0 1.3 1 0 0 1 1 1 1 Dioxygenase PALB2_WD40 PF16756.5 CCF46520.1 - 0.1 11.5 0.0 0.2 10.6 0.0 1.4 1 0 0 1 1 1 0 Partner and localizer of BRCA2 WD40 domain Phosphodiest PF01663.22 CCF46521.1 - 5.8e-16 59.0 1.4 5.8e-16 59.0 1.4 1.9 2 1 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 CCF46521.1 - 4.3e-07 29.6 0.0 1.3e-06 28.0 0.0 1.7 1 1 0 2 2 2 1 Sulfatase Metalloenzyme PF01676.18 CCF46521.1 - 0.00021 20.7 0.9 0.00036 20.0 0.9 1.3 1 0 0 1 1 1 1 Metalloenzyme superfamily PglZ PF08665.12 CCF46521.1 - 0.02 15.0 0.8 6 6.9 0.2 2.3 2 0 0 2 2 2 0 PglZ domain adh_short PF00106.25 CCF46522.1 - 2e-41 141.6 0.6 2.6e-41 141.2 0.6 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF46522.1 - 7.1e-32 110.8 0.4 8.2e-32 110.6 0.4 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF46522.1 - 3.4e-12 46.6 0.6 4.5e-12 46.3 0.6 1.1 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 CCF46522.1 - 7.8e-07 29.2 1.0 1.4e-06 28.3 1.0 1.6 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CCF46522.1 - 0.00051 19.6 0.4 0.0011 18.4 0.4 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Flot PF15975.5 CCF46522.1 - 0.0058 16.8 0.1 0.015 15.5 0.0 1.7 2 0 0 2 2 2 1 Flotillin NmrA PF05368.13 CCF46522.1 - 0.021 14.4 0.2 0.035 13.7 0.2 1.4 1 0 0 1 1 1 0 NmrA-like family TrkA_N PF02254.18 CCF46522.1 - 0.03 14.6 0.1 0.08 13.2 0.1 1.7 2 0 0 2 2 2 0 TrkA-N domain Shikimate_DH PF01488.20 CCF46522.1 - 0.072 13.1 0.1 0.12 12.5 0.1 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase DUF4267 PF14087.6 CCF46522.1 - 0.16 12.1 1.3 0.36 10.9 1.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4267) MFS_1 PF07690.16 CCF46523.1 - 3.2e-17 62.5 44.2 3.2e-17 62.5 44.2 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily SH3_1 PF00018.28 CCF46524.1 - 8.4e-16 57.3 1.7 2e-12 46.5 0.6 2.2 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.6 CCF46524.1 - 2.2e-15 56.2 1.2 2e-13 50.0 0.3 2.1 2 0 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.17 CCF46524.1 - 1.6e-11 43.7 0.0 5.1e-10 38.9 0.0 2.1 2 0 0 2 2 2 1 Variant SH3 domain A_deaminase PF00962.22 CCF46525.1 - 1.9e-122 408.7 0.1 2.6e-122 408.3 0.1 1.2 1 0 0 1 1 1 1 Adenosine/AMP deaminase UAA PF08449.11 CCF46526.1 - 5.4e-84 282.0 1.5 1.5e-52 178.7 0.0 2.0 2 0 0 2 2 2 2 UAA transporter family EamA PF00892.20 CCF46526.1 - 0.11 12.6 17.4 0.15 12.3 0.1 3.0 5 0 0 5 5 5 0 EamA-like transporter family DUF4199 PF13858.6 CCF46526.1 - 0.41 11.0 4.5 3.2 8.1 0.2 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF4199) WD40 PF00400.32 CCF46527.1 - 4.6e-12 46.3 4.3 0.21 12.5 0.1 6.4 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF46527.1 - 0.02 15.2 0.0 3 8.2 0.0 3.3 3 2 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain DUF2020 PF09449.10 CCF46527.1 - 0.066 13.0 0.1 1.4 8.8 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF2020) FOLN PF09289.10 CCF46529.1 - 0.0019 18.4 1.7 0.0054 16.9 1.7 1.9 1 0 0 1 1 1 1 Follistatin/Osteonectin-like EGF domain NifU_N PF01592.16 CCF46530.1 - 0.053 13.6 0.0 0.054 13.6 0.0 1.1 1 0 0 1 1 1 0 NifU-like N terminal domain SLC12 PF03522.15 CCF46533.1 - 3e-14 52.9 0.2 1.7e-08 33.9 0.1 2.2 2 0 0 2 2 2 2 Solute carrier family 12 Blt1_C PF17183.4 CCF46533.1 - 0.051 13.2 0.2 0.11 12.1 0.2 1.5 1 0 0 1 1 1 0 Get5 carboxyl domain DUF1751 PF08551.10 CCF46534.1 - 0.069 13.7 0.1 0.069 13.7 0.1 1.8 2 0 0 2 2 2 0 Eukaryotic integral membrane protein (DUF1751) Coprogen_oxidas PF01218.18 CCF46537.1 - 8.3e-124 412.1 0.1 1.1e-123 411.8 0.1 1.0 1 0 0 1 1 1 1 Coproporphyrinogen III oxidase DUF1651 PF07864.11 CCF46537.1 - 0.0068 16.7 0.1 0.03 14.7 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1651) COX6C PF02937.15 CCF46537.1 - 0.082 13.1 0.0 0.2 11.8 0.0 1.6 1 0 0 1 1 1 0 Cytochrome c oxidase subunit VIc Perm-CXXC PF15629.6 CCF46538.1 - 0.17 12.2 2.2 0.24 11.7 2.2 1.2 1 0 0 1 1 1 0 Permuted single zf-CXXC unit TauD PF02668.16 CCF46540.1 - 9.5e-25 87.9 0.0 1.6e-24 87.1 0.0 1.3 1 1 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family ABC_tran PF00005.27 CCF46541.1 - 1.5e-50 171.3 0.0 4.2e-24 85.6 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC2_membrane PF01061.24 CCF46541.1 - 3.7e-50 170.3 31.9 2.9e-28 98.7 10.2 3.0 3 0 0 3 3 3 2 ABC-2 type transporter AAA_21 PF13304.6 CCF46541.1 - 1.9e-13 50.9 9.2 0.00085 19.2 0.0 4.2 3 1 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 CCF46541.1 - 5.6e-09 36.1 0.4 0.0042 17.0 0.1 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 CCF46541.1 - 1.9e-08 33.9 2.2 0.0048 16.6 0.3 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain SMC_N PF02463.19 CCF46541.1 - 2.5e-08 33.6 0.4 0.00074 19.0 0.0 3.8 2 2 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CCF46541.1 - 4.4e-08 33.9 2.0 0.0006 20.4 0.1 2.4 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 CCF46541.1 - 1.5e-07 31.8 0.1 0.011 16.0 0.0 3.1 3 0 0 3 3 2 2 AAA domain AAA_16 PF13191.6 CCF46541.1 - 4.5e-07 30.4 1.4 0.04 14.3 0.0 2.9 3 0 0 3 3 2 2 AAA ATPase domain AAA_30 PF13604.6 CCF46541.1 - 1.5e-05 24.8 0.0 0.071 12.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_28 PF13521.6 CCF46541.1 - 2e-05 24.9 0.2 0.052 13.8 0.1 2.6 2 0 0 2 2 2 2 AAA domain PDR_CDR PF06422.12 CCF46541.1 - 2.2e-05 24.3 0.1 6.3e-05 22.8 0.1 1.7 1 0 0 1 1 1 1 CDR ABC transporter T2SSE PF00437.20 CCF46541.1 - 5.3e-05 22.4 0.3 0.25 10.4 0.1 2.2 2 0 0 2 2 2 2 Type II/IV secretion system protein NACHT PF05729.12 CCF46541.1 - 6e-05 23.0 0.1 0.49 10.3 0.0 2.5 2 0 0 2 2 2 2 NACHT domain AAA_25 PF13481.6 CCF46541.1 - 0.00019 21.1 0.2 0.36 10.4 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 CCF46541.1 - 0.00023 21.5 0.3 0.077 13.3 0.1 2.6 2 0 0 2 2 2 1 AAA domain AAA_15 PF13175.6 CCF46541.1 - 0.00039 20.2 0.2 2 8.1 0.0 3.2 3 0 0 3 3 3 1 AAA ATPase domain cobW PF02492.19 CCF46541.1 - 0.00047 19.8 1.5 0.71 9.4 0.3 2.3 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain MMR_HSR1 PF01926.23 CCF46541.1 - 0.001 19.2 1.6 0.59 10.2 0.1 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_24 PF13479.6 CCF46541.1 - 0.0012 18.7 0.4 0.7 9.6 0.1 2.4 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 CCF46541.1 - 0.0013 19.3 0.0 1.1 9.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain ATP_bind_1 PF03029.17 CCF46541.1 - 0.0018 18.1 0.2 0.67 9.7 0.1 2.6 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein RNA_helicase PF00910.22 CCF46541.1 - 0.0029 18.0 0.1 2.3 8.7 0.0 2.6 2 0 0 2 2 2 1 RNA helicase SbcCD_C PF13558.6 CCF46541.1 - 0.0069 16.6 0.7 5.4 7.3 0.0 3.6 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit ATPase_2 PF01637.18 CCF46541.1 - 0.014 15.4 0.0 1.5 8.7 0.0 2.4 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea ABC_ATPase PF09818.9 CCF46541.1 - 0.016 14.1 0.4 2.4 6.9 0.2 3.0 3 0 0 3 3 3 0 Predicted ATPase of the ABC class AAA_33 PF13671.6 CCF46541.1 - 0.016 15.4 0.0 9.8 6.3 0.0 2.7 2 0 0 2 2 2 0 AAA domain PDR_assoc PF08370.11 CCF46541.1 - 0.017 14.9 0.4 0.074 12.8 0.4 2.1 1 0 0 1 1 1 0 Plant PDR ABC transporter associated PduV-EutP PF10662.9 CCF46541.1 - 0.017 14.9 0.5 4.9 6.9 0.1 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation FtsK_SpoIIIE PF01580.18 CCF46541.1 - 0.019 14.3 4.7 1.1 8.6 1.3 2.5 2 1 0 2 2 2 0 FtsK/SpoIIIE family AAA_5 PF07728.14 CCF46541.1 - 0.021 14.8 0.2 5.4 7.0 0.0 2.8 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) PhoH PF02562.16 CCF46541.1 - 0.021 14.3 0.3 1.1 8.6 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein Roc PF08477.13 CCF46541.1 - 0.023 14.9 0.1 8.2 6.7 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase IstB_IS21 PF01695.17 CCF46541.1 - 0.025 14.3 0.9 2.7 7.7 0.0 3.3 4 0 0 4 4 4 0 IstB-like ATP binding protein AAA_11 PF13086.6 CCF46541.1 - 0.029 14.2 0.1 1.5 8.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain MobB PF03205.14 CCF46541.1 - 0.036 14.0 0.3 3.7 7.5 0.1 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Pox_A32 PF04665.12 CCF46541.1 - 0.037 13.5 2.5 0.49 9.8 0.1 2.6 3 0 0 3 3 3 0 Poxvirus A32 protein AAA_7 PF12775.7 CCF46541.1 - 0.039 13.5 0.4 3.4 7.1 0.0 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region Zeta_toxin PF06414.12 CCF46541.1 - 0.039 13.2 0.3 4.4 6.5 0.1 2.4 2 0 0 2 2 2 0 Zeta toxin NTPase_1 PF03266.15 CCF46541.1 - 0.049 13.5 0.8 6.7 6.6 0.1 3.6 4 0 0 4 4 4 0 NTPase Septin PF00735.18 CCF46541.1 - 0.058 12.7 0.3 2.4 7.4 0.1 2.2 2 0 0 2 2 2 0 Septin PRK PF00485.18 CCF46541.1 - 0.082 12.6 0.4 3.1 7.5 0.1 2.2 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family SRPRB PF09439.10 CCF46541.1 - 0.11 12.0 0.6 5.2 6.5 0.0 2.4 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit AAA PF00004.29 CCF46541.1 - 0.13 12.7 0.4 5.8 7.4 0.0 3.1 3 1 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 CCF46541.1 - 0.17 11.9 0.0 17 5.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.6 CCF46541.1 - 0.18 12.3 0.1 3.6 8.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.9 CCF46541.1 - 0.21 10.8 0.1 15 4.7 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) KAP_NTPase PF07693.14 CCF46541.1 - 0.23 10.6 0.0 7.4 5.7 0.0 2.2 2 0 0 2 2 2 0 KAP family P-loop domain Tho2 PF11262.8 CCF46543.1 - 6.5 5.9 6.0 2.2 7.4 2.7 1.7 1 1 1 2 2 2 0 Transcription factor/nuclear export subunit protein 2 COX16 PF14138.6 CCF46546.1 - 0.11 13.1 0.0 0.11 13.0 0.0 1.1 1 0 0 1 1 1 0 Cytochrome c oxidase assembly protein COX16 DDE_1 PF03184.19 CCF46547.1 - 9.7e-09 35.1 0.0 3.5e-08 33.3 0.0 1.9 2 1 0 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 CCF46547.1 - 1.4e-05 25.0 0.5 3.6e-05 23.7 0.1 1.9 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain Amidohydro_1 PF01979.20 CCF46548.1 - 3.8e-58 197.4 0.0 4.4e-58 197.2 0.0 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 CCF46548.1 - 1.9e-10 40.9 0.0 3.3e-07 30.1 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase family A_deaminase PF00962.22 CCF46548.1 - 0.021 14.2 0.0 0.042 13.2 0.0 1.4 1 0 0 1 1 1 0 Adenosine/AMP deaminase YlbD_coat PF14071.6 CCF46548.1 - 0.063 13.5 0.0 0.7 10.1 0.0 2.1 2 0 0 2 2 2 0 Putative coat protein APH PF01636.23 CCF46550.1 - 0.00034 20.6 0.0 0.00056 19.9 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family GRAM PF02893.20 CCF46551.1 - 2.7e-31 107.8 1.1 1.5e-19 69.9 0.0 3.4 3 0 0 3 3 3 3 GRAM domain Glyco_transf_28 PF03033.20 CCF46551.1 - 7e-30 103.9 0.0 2.1e-29 102.3 0.0 1.9 2 0 0 2 2 2 1 Glycosyltransferase family 28 N-terminal domain PH PF00169.29 CCF46551.1 - 8e-15 55.2 0.0 3e-14 53.4 0.0 2.1 2 0 0 2 2 2 1 PH domain PH_11 PF15413.6 CCF46551.1 - 0.00015 22.1 0.9 0.00015 22.1 0.9 3.2 3 1 0 3 3 3 1 Pleckstrin homology domain PH_8 PF15409.6 CCF46551.1 - 0.00015 21.9 0.2 0.00062 20.0 0.0 2.1 2 0 0 2 2 2 1 Pleckstrin homology domain UDPGT PF00201.18 CCF46551.1 - 0.002 17.0 0.1 0.0064 15.3 0.1 1.7 1 1 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase PH_6 PF15406.6 CCF46551.1 - 0.039 14.2 0.9 0.35 11.2 0.0 2.7 2 0 0 2 2 2 0 Pleckstrin homology domain PBECR1 PF18809.1 CCF46551.1 - 0.061 14.0 0.0 0.89 10.3 0.0 2.6 2 0 0 2 2 2 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease1 SUIM_assoc PF16619.5 CCF46551.1 - 0.92 9.6 9.8 0.06 13.4 1.8 2.7 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 NIF PF03031.18 CCF46552.1 - 1.1e-27 96.7 0.0 5.9e-27 94.4 0.0 2.0 2 0 0 2 2 2 1 NLI interacting factor-like phosphatase BRCT PF00533.26 CCF46552.1 - 5.3e-07 29.9 0.0 1.5e-06 28.5 0.0 1.8 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 CCF46552.1 - 2e-05 24.4 0.1 6.5e-05 22.8 0.0 1.9 2 0 0 2 2 2 1 twin BRCT domain RTT107_BRCT_5 PF16770.5 CCF46552.1 - 0.0013 18.6 0.0 0.0041 17.0 0.0 1.8 1 0 0 1 1 1 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT_2 PF16589.5 CCF46552.1 - 0.01 16.2 0.0 0.023 15.1 0.0 1.6 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain BRCT_3 PF18428.1 CCF46552.1 - 0.093 12.8 2.2 0.1 12.7 0.5 1.9 2 0 0 2 2 2 0 BRCA1 C Terminus (BRCT) domain Biotin_lipoyl PF00364.22 CCF46552.1 - 0.12 12.2 0.0 19 5.2 0.0 2.6 2 0 0 2 2 2 0 Biotin-requiring enzyme LIG3_BRCT PF16759.5 CCF46552.1 - 0.15 12.3 0.2 0.33 11.3 0.2 1.5 1 0 0 1 1 1 0 DNA ligase 3 BRCT domain Zn_clus PF00172.18 CCF46553.1 - 1.4e-06 28.3 5.9 2.2e-06 27.7 5.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CCF46553.1 - 0.00014 21.0 0.3 0.00019 20.6 0.3 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Pex14_N PF04695.13 CCF46553.1 - 0.96 10.1 5.1 2.2 9.0 5.1 1.5 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Swi3 PF07962.12 CCF46554.1 - 4.7e-30 103.4 1.0 8.2e-30 102.6 0.4 1.7 2 0 0 2 2 2 1 Replication Fork Protection Component Swi3 PALP PF00291.25 CCF46555.1 - 9.1e-25 87.7 0.3 1.1e-24 87.4 0.3 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DGF-1_C PF11040.8 CCF46556.1 - 0.24 11.4 2.6 0.47 10.5 2.6 1.5 1 0 0 1 1 1 0 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus SMYLE_N PF18615.1 CCF46556.1 - 5.7 6.4 5.9 7 6.1 5.9 1.0 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain Peptidase_S8 PF00082.22 CCF46557.1 - 9.3e-17 61.2 0.3 1.9e-16 60.2 0.3 1.4 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 CCF46557.1 - 0.044 14.4 0.1 0.07 13.8 0.1 1.4 1 0 0 1 1 1 0 Peptidase inhibitor I9 p450 PF00067.22 CCF46558.1 - 2.6e-11 42.9 0.0 3.3e-11 42.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DASH_Ask1 PF08655.10 CCF46559.1 - 0.05 13.5 0.0 0.08 12.8 0.0 1.5 1 0 0 1 1 1 0 DASH complex subunit Ask1 JmjC PF02373.22 CCF46559.1 - 0.11 13.0 0.1 0.11 12.9 0.1 1.0 1 0 0 1 1 1 0 JmjC domain, hydroxylase GCS PF03074.16 CCF46560.1 - 1.4e-29 103.6 0.0 1.6e-29 103.4 0.0 1.0 1 0 0 1 1 1 1 Glutamate-cysteine ligase Crystall_3 PF08964.10 CCF46561.1 - 8.7e-06 25.8 0.2 0.028 14.6 0.0 2.1 1 1 1 2 2 2 2 Beta/Gamma crystallin Inhibitor_I36 PF03995.13 CCF46561.1 - 0.015 15.2 3.6 0.35 10.8 0.7 2.2 1 1 1 2 2 2 0 Peptidase inhibitor family I36 Crystall PF00030.19 CCF46561.1 - 0.018 15.2 0.2 0.025 14.8 0.2 1.2 1 0 0 1 1 1 0 Beta/Gamma crystallin AAA PF00004.29 CCF46562.1 - 5.4e-17 62.5 0.0 1e-16 61.6 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) CAP_N PF01213.19 CCF46562.1 - 0.45 9.9 5.4 0.62 9.5 5.4 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Isochorismatase PF00857.20 CCF46563.1 - 4.1e-31 108.5 0.2 5.1e-31 108.2 0.2 1.1 1 0 0 1 1 1 1 Isochorismatase family HK PF02110.15 CCF46564.1 - 9.9e-48 162.7 0.1 1.3e-47 162.3 0.1 1.0 1 0 0 1 1 1 1 Hydroxyethylthiazole kinase family Carb_kinase PF01256.17 CCF46564.1 - 0.00041 19.9 0.1 0.00059 19.4 0.1 1.3 1 1 0 1 1 1 1 Carbohydrate kinase Phos_pyr_kin PF08543.12 CCF46564.1 - 0.0068 15.8 0.0 0.0086 15.5 0.0 1.2 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase DUF1018 PF06252.12 CCF46564.1 - 0.15 13.0 0.4 0.76 10.8 0.1 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF1018) Zn_clus PF00172.18 CCF46566.1 - 0.00015 21.8 2.6 0.00026 21.0 0.9 2.1 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PRP4 PF08799.11 CCF46568.1 - 7.9e-12 44.5 4.2 7.9e-12 44.5 4.2 2.8 3 0 0 3 3 3 1 pre-mRNA processing factor 4 (PRP4) like Borrelia_P83 PF05262.11 CCF46568.1 - 0.0056 15.2 10.3 0.0051 15.4 10.3 1.1 1 0 0 1 1 1 1 Borrelia P83/100 protein AP3D1 PF06375.11 CCF46568.1 - 0.099 12.9 14.2 0.25 11.6 14.2 1.7 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 V_ATPase_I PF01496.19 CCF46568.1 - 0.099 10.5 2.9 0.13 10.2 2.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CDC45 PF02724.14 CCF46568.1 - 0.33 9.2 9.6 0.28 9.4 9.6 1.2 1 0 0 1 1 1 0 CDC45-like protein HTH_psq PF05225.16 CCF46570.1 - 3.1e-09 36.4 0.0 6.7e-09 35.4 0.0 1.6 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.16 CCF46570.1 - 3.9e-06 26.8 0.0 9.4e-06 25.6 0.0 1.6 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain MFS_1 PF07690.16 CCF46572.1 - 9.8e-28 97.1 29.3 9.8e-28 97.1 29.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Atg14 PF10186.9 CCF46573.1 - 2.7e-73 246.8 0.0 3.6e-73 246.4 0.0 1.1 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 Glyco_hydro_88 PF07470.13 CCF46575.1 - 1.5e-90 303.7 0.7 1.8e-90 303.5 0.7 1.0 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 Glyco_hydro_76 PF03663.14 CCF46575.1 - 0.12 11.9 2.9 0.11 11.9 1.1 1.9 2 1 0 2 2 2 0 Glycosyl hydrolase family 76 MFS_1 PF07690.16 CCF46576.1 - 8.3e-36 123.6 23.1 1.2e-35 123.1 23.1 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF3827 PF12877.7 CCF46576.1 - 0.12 10.7 0.3 0.29 9.4 0.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) DUF4231 PF14015.6 CCF46576.1 - 0.19 12.2 2.9 8.7 6.9 0.0 3.5 3 1 0 3 3 3 0 Protein of unknown function (DUF4231) DUF1003 PF06210.11 CCF46576.1 - 0.86 9.7 3.2 0.95 9.6 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1003) EI24 PF07264.11 CCF46578.1 - 0.059 13.6 1.3 0.059 13.6 1.3 2.2 2 0 0 2 2 2 0 Etoposide-induced protein 2.4 (EI24) TctB PF07331.11 CCF46578.1 - 2.1 8.6 8.4 0.41 10.9 2.5 2.5 2 1 1 3 3 3 0 Tripartite tricarboxylate transporter TctB family Gp_dh_C PF02800.20 CCF46579.1 - 1.4e-63 213.2 0.2 1.6e-63 213.0 0.2 1.0 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Fungal_trans PF04082.18 CCF46581.1 - 0.0002 20.5 0.0 0.00032 19.8 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain 7tm_1 PF00001.21 CCF46582.1 - 0.0028 17.0 0.7 0.0028 17.0 0.7 1.6 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) Aconitase PF00330.20 CCF46584.1 - 3.1e-72 244.1 0.0 3.3e-70 237.4 0.0 2.1 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 CCF46584.1 - 9.3e-15 55.1 0.0 2.5e-14 53.7 0.0 1.7 1 0 0 1 1 1 1 Aconitase C-terminal domain p450 PF00067.22 CCF46585.1 - 1.7e-61 208.4 0.0 2.5e-61 207.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Fas_alpha_ACP PF18325.1 CCF46585.1 - 5.1e-38 131.0 0.0 8.2e-38 130.3 0.0 1.3 1 0 0 1 1 1 1 Fatty acid synthase subunit alpha Acyl carrier domain FAS_I_H PF18314.1 CCF46585.1 - 1.8e-29 102.8 0.0 4.6e-29 101.5 0.0 1.7 1 0 0 1 1 1 1 Fatty acid synthase type I helical domain adh_short PF00106.25 CCF46585.1 - 9.6e-05 21.9 0.1 0.00038 20.0 0.0 2.0 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 CCF46585.1 - 0.042 13.8 0.0 0.092 12.6 0.0 1.6 1 0 0 1 1 1 0 KR domain CBFD_NFYB_HMF PF00808.23 CCF46586.1 - 1.9e-12 47.3 0.0 3.3e-12 46.5 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 CCF46586.1 - 0.0076 16.6 0.3 0.042 14.2 0.0 2.0 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 MBOAT PF03062.19 CCF46587.1 - 2.4e-35 122.5 22.1 1.5e-34 119.9 22.1 2.0 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family Cytochrom_B561 PF03188.16 CCF46587.1 - 0.0077 16.4 2.0 0.014 15.5 2.0 1.6 1 0 0 1 1 1 1 Eukaryotic cytochrome b561 MBOAT_2 PF13813.6 CCF46587.1 - 0.84 10.0 9.3 1.4 9.2 5.3 2.7 2 1 0 2 2 2 0 Membrane bound O-acyl transferase family Dioxygenase_C PF00775.21 CCF46589.1 - 1.3e-38 132.3 0.0 1.7e-38 131.9 0.0 1.2 1 0 0 1 1 1 1 Dioxygenase Dioxygenase_N PF04444.14 CCF46589.1 - 1.3e-25 89.1 0.0 1.9e-25 88.5 0.0 1.3 1 0 0 1 1 1 1 Catechol dioxygenase N terminus SpaA PF17802.1 CCF46589.1 - 0.00066 20.0 0.1 0.0015 18.8 0.1 1.6 1 0 0 1 1 1 1 Prealbumin-like fold domain CarboxypepD_reg PF13620.6 CCF46589.1 - 0.0067 16.7 0.0 0.031 14.5 0.0 2.1 1 1 0 1 1 1 1 Carboxypeptidase regulatory-like domain p450 PF00067.22 CCF46590.1 - 7.9e-48 163.3 0.0 8.6e-48 163.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Proteasome PF00227.26 CCF46591.1 - 2e-51 174.2 0.0 2.2e-27 95.8 0.0 2.1 2 0 0 2 2 2 2 Proteasome subunit zf-C2H2 PF00096.26 CCF46593.1 - 4.8e-13 48.8 16.3 3.8e-05 23.9 1.6 4.0 3 1 1 4 4 4 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CCF46593.1 - 9.1e-11 41.7 8.5 0.00015 22.0 0.1 3.9 4 1 0 4 4 3 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 CCF46593.1 - 5.2e-10 39.3 10.9 7.6e-05 23.2 0.8 3.8 3 0 0 3 3 3 3 C2H2-type zinc finger zf-met PF12874.7 CCF46593.1 - 3e-08 33.8 2.6 0.0034 17.7 0.1 3.5 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 CCF46593.1 - 7.6e-07 29.3 1.0 0.091 13.1 0.1 3.5 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 CCF46593.1 - 4.5e-06 26.5 6.2 0.04 13.9 0.1 3.8 3 1 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_11 PF16622.5 CCF46593.1 - 0.00016 21.3 8.9 0.0016 18.2 0.3 3.4 3 0 0 3 3 3 1 zinc-finger C2H2-type zf-Di19 PF05605.12 CCF46593.1 - 0.012 15.9 0.6 0.028 14.7 0.6 1.7 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding Endonuclease_7 PF02945.15 CCF46593.1 - 0.016 15.1 1.0 0.029 14.3 1.0 1.4 1 0 0 1 1 1 0 Recombination endonuclease VII LIM PF00412.22 CCF46593.1 - 0.057 13.7 6.7 1.7 8.9 0.5 2.8 3 1 0 3 3 3 0 LIM domain C5HCH PF17982.1 CCF46593.1 - 0.079 13.1 4.9 5.3 7.3 0.7 2.6 2 0 0 2 2 2 0 NSD Cys-His rich domain zf-C2H2_2 PF12756.7 CCF46593.1 - 0.14 12.5 2.2 1.2 9.5 0.1 2.4 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) Zn_ribbon_recom PF13408.6 CCF46593.1 - 0.2 12.2 5.3 0.068 13.7 2.4 1.7 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain zf-CCHC_2 PF13696.6 CCF46593.1 - 0.57 10.1 3.9 25 4.8 0.1 3.2 3 0 0 3 3 3 0 Zinc knuckle zf-BED PF02892.15 CCF46593.1 - 0.82 9.7 4.3 41 4.3 0.1 3.3 3 0 0 3 3 3 0 BED zinc finger zf-LYAR PF08790.11 CCF46593.1 - 0.92 9.5 4.3 14 5.7 0.0 2.8 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger zf-C2HE PF16278.5 CCF46593.1 - 0.95 10.0 5.4 3.6 8.1 0.6 2.6 2 1 1 3 3 2 0 C2HE / C2H2 / C2HC zinc-binding finger Zn_ribbon_SprT PF17283.2 CCF46593.1 - 5 7.1 11.2 0.47 10.4 2.5 3.0 2 1 1 3 3 3 0 SprT-like zinc ribbon domain FYVE PF01363.21 CCF46593.1 - 9.4 6.5 11.9 1.3e+02 2.8 12.0 2.5 1 1 0 1 1 1 0 FYVE zinc finger DUF3425 PF11905.8 CCF46594.1 - 2.5e-19 69.4 0.0 4.3e-19 68.7 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) Polyketide_cyc2 PF10604.9 CCF46595.1 - 0.013 15.8 1.3 0.022 15.0 0.3 1.9 1 1 1 2 2 2 0 Polyketide cyclase / dehydrase and lipid transport His_Phos_1 PF00300.22 CCF46596.1 - 1.4e-17 64.0 0.4 1.8e-15 57.2 0.0 2.4 2 1 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) PKD_channel PF08016.12 CCF46598.1 - 0.0057 15.4 0.5 0.008 14.9 0.5 1.2 1 0 0 1 1 1 1 Polycystin cation channel SNF2_N PF00176.23 CCF46599.1 - 5.9e-36 123.9 0.0 7.5e-36 123.6 0.0 1.1 1 0 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.15 CCF46599.1 - 2e-06 27.9 0.0 3.2e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 CCF46599.1 - 0.076 12.8 0.2 0.35 10.6 0.2 2.0 1 1 0 1 1 1 0 DEAD/DEAH box helicase Cytochrom_B558a PF05038.13 CCF46599.1 - 0.088 12.4 0.0 0.3 10.6 0.0 1.7 2 0 0 2 2 2 0 Cytochrome Cytochrome b558 alpha-subunit PrpF PF04303.13 CCF46601.1 - 2e-97 326.5 2.0 2.9e-89 299.6 0.6 2.0 2 0 0 2 2 2 2 PrpF protein ADH_N PF08240.12 CCF46602.1 - 5.3e-25 87.4 6.8 1e-24 86.5 6.8 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCF46602.1 - 3.5e-23 82.0 0.2 3.4e-22 78.8 0.0 2.5 3 0 0 3 3 3 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 CCF46602.1 - 5e-05 22.7 0.0 9.3e-05 21.8 0.0 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 CCF46602.1 - 7.2e-05 22.2 0.2 0.00012 21.4 0.2 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ADH_zinc_N_2 PF13602.6 CCF46602.1 - 0.0011 20.0 0.0 0.002 19.2 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ApbA PF02558.16 CCF46602.1 - 0.049 13.3 0.0 0.079 12.6 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA DUF2855 PF11017.8 CCF46603.1 - 5.1e-99 332.2 0.1 5.9e-99 332.0 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2855) PA_decarbox PF05870.11 CCF46604.1 - 7.9e-09 35.3 0.2 1.1e-08 34.8 0.2 1.2 1 0 0 1 1 1 1 Phenolic acid decarboxylase (PAD) U3_snoRNA_assoc PF08297.11 CCF46606.1 - 3e-14 53.5 2.3 3e-14 53.5 2.3 4.7 2 1 1 3 3 3 1 U3 snoRNA associated Lyase_aromatic PF00221.19 CCF46608.1 - 3e-145 484.4 2.2 3.5e-145 484.3 2.2 1.0 1 0 0 1 1 1 1 Aromatic amino acid lyase DUF4142 PF13628.6 CCF46609.1 - 0.11 12.8 1.1 0.3 11.3 0.4 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4142) UQ_con PF00179.26 CCF46610.1 - 3.9e-18 65.5 0.0 6.2e-18 64.8 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 CCF46610.1 - 0.15 12.3 0.0 0.34 11.2 0.0 1.6 1 0 0 1 1 1 0 RWD domain NADH_B2 PF14813.6 CCF46611.1 - 0.038 13.8 0.1 0.043 13.6 0.1 1.2 1 0 0 1 1 1 0 NADH dehydrogenase 1 beta subcomplex subunit 2 CMAS PF02353.20 CCF46612.1 - 1.6e-38 132.6 0.8 2.2e-38 132.2 0.8 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_11 PF08241.12 CCF46612.1 - 5.2e-17 62.3 0.0 8.8e-17 61.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF46612.1 - 8.8e-17 61.6 0.0 1.6e-16 60.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF46612.1 - 1.6e-14 53.9 0.0 2.4e-14 53.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF46612.1 - 8.6e-12 45.2 0.0 1.3e-11 44.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF46612.1 - 6.9e-11 42.8 0.0 1.1e-10 42.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCF46612.1 - 2.5e-08 33.5 0.0 3.8e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 CCF46612.1 - 1.3e-07 31.3 0.0 2.5e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain DUF938 PF06080.12 CCF46612.1 - 9.7e-06 25.5 0.0 1.7e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF938) Methyltransf_4 PF02390.17 CCF46612.1 - 0.00015 21.3 0.0 0.00044 19.7 0.0 1.7 2 0 0 2 2 2 1 Putative methyltransferase TehB PF03848.14 CCF46612.1 - 0.00026 20.5 0.0 0.00045 19.7 0.0 1.3 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltr_RsmB-F PF01189.17 CCF46612.1 - 0.0016 18.1 0.0 0.0032 17.2 0.0 1.4 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F PCMT PF01135.19 CCF46612.1 - 0.002 17.9 0.4 0.0044 16.8 0.0 1.8 2 1 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) GidB PF02527.15 CCF46612.1 - 0.0081 15.5 0.0 0.015 14.6 0.0 1.4 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G Methyltransf_2 PF00891.18 CCF46612.1 - 0.12 11.6 0.0 0.23 10.7 0.0 1.4 1 0 0 1 1 1 0 O-methyltransferase domain Cation_ATPase_C PF00689.21 CCF46613.1 - 2.6e-05 24.0 4.5 2.6e-05 24.0 4.5 1.6 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 CCF46613.1 - 0.00018 21.8 0.0 0.0003 21.2 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Abhydrolase_9_N PF15420.6 CCF46613.1 - 0.0083 16.2 0.2 0.0083 16.2 0.2 1.5 2 0 0 2 2 2 1 Alpha/beta-hydrolase family N-terminus IDO PF01231.18 CCF46615.1 - 1.4e-07 30.7 0.0 2.3e-07 30.0 0.0 1.3 1 1 0 1 1 1 1 Indoleamine 2,3-dioxygenase PGI PF00342.19 CCF46617.1 - 6.7e-76 255.8 0.0 7.4e-76 255.7 0.0 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase CHCH PF06747.13 CCF46618.1 - 9.9e-06 25.6 3.3 9.9e-06 25.6 3.3 1.9 2 0 0 2 2 2 1 CHCH domain CX9C PF16860.5 CCF46618.1 - 0.00022 21.1 7.0 0.0017 18.3 3.3 2.2 2 0 0 2 2 2 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, DnaT PF17948.1 CCF46618.1 - 0.12 12.1 0.0 1.9 8.2 0.0 2.0 2 0 0 2 2 2 0 DnaT DNA-binding domain Cmc1 PF08583.10 CCF46618.1 - 2.9 8.0 8.2 1.1 9.3 3.2 2.1 1 1 1 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like Tannase PF07519.11 CCF46619.1 - 2.9e-08 33.1 0.2 3.1e-08 33.0 0.2 1.0 1 0 0 1 1 1 1 Tannase and feruloyl esterase Peptidase_M35 PF02102.15 CCF46620.1 - 6.2e-67 226.0 14.7 6.9e-67 225.8 14.7 1.0 1 0 0 1 1 1 1 Deuterolysin metalloprotease (M35) family Aspzincin_M35 PF14521.6 CCF46620.1 - 2.6e-21 76.7 2.7 2.6e-21 76.7 2.7 1.6 1 1 0 1 1 1 1 Lysine-specific metallo-endopeptidase HepII_C PF18675.1 CCF46620.1 - 0.06 13.4 0.6 4.2 7.5 0.1 2.5 2 0 0 2 2 2 0 Heparinase II C-terminal domain adh_short PF00106.25 CCF46621.1 - 4.7e-14 52.3 0.1 1e-13 51.2 0.1 1.5 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF46621.1 - 1.1e-12 48.0 0.1 1.9e-12 47.3 0.1 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF46621.1 - 7.1e-09 35.8 0.0 1.3e-08 34.9 0.0 1.4 1 0 0 1 1 1 1 KR domain Acetate_kinase PF00871.17 CCF46621.1 - 0.11 11.1 0.0 0.16 10.7 0.0 1.2 1 0 0 1 1 1 0 Acetokinase family Acyl-CoA_dh_1 PF00441.24 CCF46622.1 - 1.7e-40 138.6 0.9 3.1e-40 137.8 0.9 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 CCF46622.1 - 8.8e-31 106.9 0.1 1.8e-30 105.9 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 CCF46622.1 - 1.6e-27 95.5 0.3 3.2e-27 94.6 0.3 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 CCF46622.1 - 4.5e-14 52.9 0.1 8.9e-14 51.9 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.8 CCF46622.1 - 5.8e-05 22.9 0.1 0.00014 21.6 0.1 1.6 1 1 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase N terminal Carboxyl_trans PF01039.22 CCF46623.1 - 1.2e-138 462.9 0.1 1.6e-138 462.4 0.1 1.1 1 0 0 1 1 1 1 Carboxyl transferase domain NUDIX PF00293.28 CCF46624.1 - 1.3e-09 38.2 0.2 4.7e-09 36.4 0.2 1.8 1 1 0 1 1 1 1 NUDIX domain HTH_psq PF05225.16 CCF46625.1 - 7e-11 41.7 0.0 1.6e-10 40.6 0.0 1.6 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.16 CCF46625.1 - 4.6e-09 36.2 0.0 1.2e-08 34.9 0.0 1.7 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_23 PF13384.6 CCF46625.1 - 0.0044 16.8 0.1 0.037 13.8 0.0 2.3 2 0 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.6 CCF46625.1 - 0.041 14.0 0.1 0.28 11.3 0.0 2.4 3 0 0 3 3 3 0 Helix-turn-helix domain Methyltransf_2 PF00891.18 CCF46626.1 - 3.5e-14 52.6 0.0 1.2e-13 50.9 0.0 1.7 1 1 0 1 1 1 1 O-methyltransferase domain Methyltransf_25 PF13649.6 CCF46626.1 - 0.0023 18.6 0.0 0.0044 17.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF46626.1 - 0.025 14.4 0.0 0.086 12.7 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 CCF46626.1 - 0.079 13.7 0.0 0.14 12.9 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain MFS_1 PF07690.16 CCF46628.1 - 4.1e-28 98.3 12.4 5e-28 98.0 12.4 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF46628.1 - 5.3e-07 28.9 5.2 7.3e-07 28.4 5.1 1.3 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_4 PF06779.14 CCF46628.1 - 0.00035 20.0 5.1 0.00076 18.9 4.4 1.8 1 1 1 2 2 2 1 Uncharacterised MFS-type transporter YbfB TRI12 PF06609.13 CCF46628.1 - 0.0032 16.0 1.7 0.0043 15.5 1.7 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Senescence PF06911.12 CCF46630.1 - 1e-55 188.9 3.3 1.7e-55 188.2 3.3 1.4 1 0 0 1 1 1 1 Senescence-associated protein GCP_N_terminal PF17681.1 CCF46631.1 - 4.1e-28 98.9 0.0 6.1e-28 98.3 0.0 1.2 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 CCF46631.1 - 6.6e-25 88.2 0.0 1.5e-24 87.0 0.0 1.5 1 1 0 1 1 1 1 Gamma tubulin complex component C-terminal Vps51 PF08700.11 CCF46632.1 - 1.7e-30 104.9 0.1 3.3e-30 104.0 0.0 1.5 2 0 0 2 2 2 1 Vps51/Vps67 Dor1 PF04124.12 CCF46632.1 - 0.0004 19.2 0.2 0.00055 18.7 0.2 1.1 1 0 0 1 1 1 1 Dor1-like family COG5 PF10392.9 CCF46632.1 - 0.00058 20.0 0.0 0.00096 19.3 0.0 1.3 1 0 0 1 1 1 1 Golgi transport complex subunit 5 NIF3 PF01784.18 CCF46633.1 - 3.2e-53 180.9 0.0 2.1e-51 174.9 0.0 2.0 1 1 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) F420_oxidored PF03807.17 CCF46633.1 - 0.054 14.1 0.2 8.9 7.0 0.1 2.3 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent BolA PF01722.18 CCF46634.1 - 5.5e-20 71.4 0.1 1.4e-19 70.1 0.1 1.6 1 1 0 1 1 1 1 BolA-like protein zf-C2H2_11 PF16622.5 CCF46634.1 - 0.2 11.4 0.4 8.3 6.3 0.0 2.3 2 0 0 2 2 2 0 zinc-finger C2H2-type Adaptin_N PF01602.20 CCF46635.1 - 7.8e-138 460.3 3.7 1.1e-137 459.8 3.7 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 CCF46635.1 - 1.4e-63 213.8 3.0 2.2e-61 206.7 0.1 2.9 3 1 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 CCF46635.1 - 5.2e-17 62.0 0.2 2.2e-07 31.2 0.0 5.3 2 2 3 5 5 5 4 HEAT repeats HEAT PF02985.22 CCF46635.1 - 7.2e-11 41.4 4.8 0.023 14.9 0.0 6.4 8 0 0 8 8 8 2 HEAT repeat UNC45-central PF11701.8 CCF46635.1 - 0.00012 22.1 0.1 0.23 11.4 0.0 2.8 2 0 0 2 2 2 2 Myosin-binding striated muscle assembly central HEAT_EZ PF13513.6 CCF46635.1 - 0.00015 22.2 0.1 0.65 10.6 0.0 4.6 3 1 1 4 4 4 1 HEAT-like repeat RIX1 PF08167.12 CCF46635.1 - 0.013 15.3 0.2 4.2 7.1 0.0 2.9 3 0 0 3 3 3 0 rRNA processing/ribosome biogenesis Arm PF00514.23 CCF46635.1 - 0.022 14.8 1.1 16 5.7 0.0 4.9 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 CCF46635.1 - 0.023 14.7 0.0 3.1 7.9 0.0 3.4 2 1 1 3 3 3 0 Spinocerebellar ataxia type 10 protein domain CLASP_N PF12348.8 CCF46635.1 - 0.07 12.7 0.1 2.1 7.9 0.0 2.9 2 1 1 3 3 3 0 CLASP N terminal RTP1_C1 PF10363.9 CCF46635.1 - 0.15 12.2 0.6 6.3 7.0 0.0 3.7 2 2 1 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 DNA_ligase_A_M PF01068.21 CCF46636.1 - 4.9e-50 170.0 0.6 1.6e-47 161.8 0.0 2.3 2 0 0 2 2 2 2 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 CCF46636.1 - 2.8e-36 125.5 0.0 5.3e-36 124.5 0.0 1.5 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 CCF46636.1 - 4.4e-20 72.1 0.0 5.3e-19 68.7 0.0 2.7 3 0 0 3 3 3 1 ATP dependent DNA ligase C terminal region RNA_ligase PF09414.10 CCF46636.1 - 0.00024 21.4 0.0 0.0012 19.2 0.0 2.0 2 0 0 2 2 2 1 RNA ligase mRNA_cap_enzyme PF01331.19 CCF46636.1 - 0.0043 16.9 0.1 1.1 9.0 0.0 2.3 2 0 0 2 2 2 2 mRNA capping enzyme, catalytic domain NuDC PF16273.5 CCF46636.1 - 0.052 14.1 0.4 0.052 14.1 0.4 2.3 2 0 0 2 2 2 0 Nuclear distribution C domain CSN8_PSD8_EIF3K PF10075.9 CCF46637.1 - 5.1e-39 133.5 0.0 6.9e-39 133.1 0.0 1.2 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family PDCD2_C PF04194.13 CCF46638.1 - 7e-43 146.7 0.3 5.2e-42 143.9 0.0 2.4 3 1 0 3 3 3 1 Programmed cell death protein 2, C-terminal putative domain Cpn60_TCP1 PF00118.24 CCF46639.1 - 2.9e-163 544.0 0.5 3.3e-163 543.8 0.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Herpes_UL6 PF01763.16 CCF46639.1 - 0.11 10.9 0.0 0.16 10.4 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like Collagen PF01391.18 CCF46640.1 - 1.3 8.9 17.3 1.6 8.6 14.6 2.4 2 1 0 2 2 2 0 Collagen triple helix repeat (20 copies) AA_permease_2 PF13520.6 CCF46641.1 - 5.5e-36 124.3 31.6 6.1e-36 124.2 31.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CCF46641.1 - 4.3e-19 68.5 25.6 5.5e-19 68.1 25.6 1.0 1 0 0 1 1 1 1 Amino acid permease Glyco_hydro_12 PF01670.16 CCF46642.1 - 7e-24 85.0 0.2 7.7e-24 84.9 0.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 12 F-box PF00646.33 CCF46643.1 - 1.3e-06 28.2 0.8 2.3e-06 27.3 0.8 1.4 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 CCF46643.1 - 1.4e-06 28.0 1.3 2.9e-06 27.1 1.3 1.5 1 0 0 1 1 1 1 F-box-like SNF2_N PF00176.23 CCF46644.1 - 2.3e-60 204.2 3.1 8.1e-60 202.4 3.1 1.6 1 1 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.15 CCF46644.1 - 1.7e-07 31.4 0.1 2.7e-07 30.8 0.1 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_34 PF13872.6 CCF46644.1 - 0.00032 19.7 0.0 0.00055 18.9 0.0 1.3 1 0 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 Corona_7 PF02398.16 CCF46645.1 - 0.13 12.9 2.0 0.22 12.1 2.0 1.4 1 0 0 1 1 1 0 Coronavirus protein 7 IL11 PF07400.11 CCF46647.1 - 0.041 13.5 0.2 0.046 13.4 0.2 1.2 1 0 0 1 1 1 0 Interleukin 11 AMP-binding PF00501.28 CCF46648.1 - 2.7e-135 451.2 0.0 1.4e-70 238.0 0.0 2.4 2 0 0 2 2 2 2 AMP-binding enzyme Condensation PF00668.20 CCF46648.1 - 1.4e-78 264.7 0.0 2.6e-17 62.7 0.0 7.4 6 2 1 7 7 7 7 Condensation domain PP-binding PF00550.25 CCF46648.1 - 1.8e-17 63.4 0.2 3.2e-09 37.0 0.1 2.8 2 0 0 2 2 2 2 Phosphopantetheine attachment site AMP-binding_C PF13193.6 CCF46648.1 - 7.6e-07 30.0 0.0 0.013 16.5 0.0 3.9 2 0 0 2 2 2 2 AMP-binding enzyme C-terminal domain Aldedh PF00171.22 CCF46649.1 - 6e-39 133.8 0.2 6.6e-39 133.7 0.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 CCF46649.1 - 0.023 13.8 0.0 0.027 13.5 0.0 1.1 1 0 0 1 1 1 0 Acyl-CoA reductase (LuxC) MlaA PF04333.13 CCF46649.1 - 0.056 13.1 0.1 0.079 12.6 0.1 1.2 1 0 0 1 1 1 0 MlaA lipoprotein PHO4 PF01384.20 CCF46652.1 - 3.9e-52 177.4 6.9 4.3e-52 177.2 6.9 1.0 1 0 0 1 1 1 1 Phosphate transporter family CPSase_L_D2 PF02786.17 CCF46653.1 - 4.2e-24 85.2 0.0 5.9e-24 84.7 0.0 1.1 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp PF02222.22 CCF46653.1 - 5.3e-11 42.4 0.0 9.7e-11 41.5 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 CCF46653.1 - 2.9e-09 36.8 0.1 4.9e-09 36.0 0.1 1.3 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.6 CCF46653.1 - 1.4e-05 24.8 0.0 5.4e-05 22.9 0.0 1.9 2 1 0 2 2 2 1 ATP-grasp in the biosynthetic pathway with Ter operon GARS_A PF01071.19 CCF46653.1 - 0.0028 17.5 0.1 0.0051 16.6 0.1 1.5 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATP-grasp_4 PF13535.6 CCF46653.1 - 0.0034 17.0 0.0 0.0083 15.7 0.0 1.6 1 1 0 1 1 1 1 ATP-grasp domain RimK PF08443.11 CCF46653.1 - 0.0062 16.2 0.0 0.011 15.3 0.0 1.4 1 0 0 1 1 1 1 RimK-like ATP-grasp domain ATP-grasp_5 PF13549.6 CCF46653.1 - 0.038 13.4 0.0 0.079 12.4 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain Epimerase PF01370.21 CCF46653.1 - 0.19 11.2 0.0 0.56 9.6 0.0 1.7 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family PH_12 PF16457.5 CCF46654.1 - 1.1 9.8 6.1 1.8 9.1 6.1 1.3 1 0 0 1 1 1 0 Pleckstrin homology domain SSP160 PF06933.11 CCF46654.1 - 1.7 6.7 44.9 0.46 8.6 2.2 2.3 2 0 0 2 2 2 0 Special lobe-specific silk protein SSP160 CDK2AP PF09806.9 CCF46654.1 - 2.6 8.1 13.7 4.5 7.3 13.7 1.4 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein DUF4834 PF16118.5 CCF46654.1 - 2.9 8.9 3.8 5.4 8.1 3.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DUF4614 PF15391.6 CCF46654.1 - 3.9 7.4 19.9 6.4 6.7 19.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) AhpC-TSA PF00578.21 CCF46656.1 - 1.9e-05 24.6 0.0 3.6e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family AhpC-TSA_2 PF13911.6 CCF46656.1 - 2.9e-05 24.2 0.2 0.0001 22.4 0.2 1.9 1 1 0 1 1 1 1 AhpC/TSA antioxidant enzyme Redoxin PF08534.10 CCF46656.1 - 0.0041 16.8 0.0 0.0065 16.2 0.0 1.2 1 0 0 1 1 1 1 Redoxin CALM_bind PF16025.5 CCF46657.1 - 0.038 14.4 5.0 0.066 13.7 5.0 1.3 1 0 0 1 1 1 0 Calcium-dependent calmodulin binding Thioredoxin_6 PF13848.6 CCF46659.1 - 0.00037 20.5 0.0 0.00058 19.8 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like domain NAD_binding_10 PF13460.6 CCF46660.1 - 7.7e-19 68.3 0.0 1.1e-18 67.8 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 CCF46660.1 - 9.1e-06 25.4 0.0 1.4e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family Semialdhyde_dh PF01118.24 CCF46660.1 - 0.041 14.3 0.0 0.068 13.6 0.0 1.4 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 CCF46660.1 - 0.07 12.1 0.0 0.093 11.7 0.0 1.1 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Sacchrp_dh_NADP PF03435.18 CCF46660.1 - 0.17 12.1 0.0 0.27 11.5 0.0 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain U79_P34 PF03064.16 CCF46661.1 - 0.0074 15.7 22.8 0.0074 15.7 22.8 2.9 2 1 0 3 3 3 1 HSV U79 / HCMV P34 ATP-grasp_2 PF08442.10 CCF46662.1 - 2.6e-08 33.7 0.0 7.8e-06 25.6 0.0 2.1 2 0 0 2 2 2 2 ATP-grasp domain FAD_binding_3 PF01494.19 CCF46663.1 - 7.7e-13 48.4 0.0 1.1e-12 47.9 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 CCF46663.1 - 2.9e-08 33.7 4.7 1e-05 25.3 1.9 2.2 1 1 1 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCF46663.1 - 1.4e-07 31.0 0.0 3.8e-06 26.4 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CCF46663.1 - 1.3e-06 27.8 0.2 3e-06 26.6 0.2 1.5 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 CCF46663.1 - 1.4e-06 28.5 0.1 4.8e-06 26.7 0.1 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 CCF46663.1 - 8.6e-06 24.7 0.4 0.0019 17.0 0.2 2.0 2 0 0 2 2 2 2 HI0933-like protein Lycopene_cycl PF05834.12 CCF46663.1 - 7.1e-05 22.0 0.0 9.5e-05 21.6 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox PF00070.27 CCF46663.1 - 0.00026 21.5 0.3 0.0077 16.8 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CCF46663.1 - 0.0023 17.1 0.1 0.0033 16.6 0.1 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A FAD_oxidored PF12831.7 CCF46663.1 - 0.0052 16.2 0.2 0.0069 15.8 0.2 1.3 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_Gly3P_dh_N PF01210.23 CCF46663.1 - 0.047 13.7 0.0 0.076 13.0 0.0 1.3 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Amino_oxidase PF01593.24 CCF46663.1 - 0.05 12.9 0.1 0.22 10.8 0.1 1.8 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase Thi4 PF01946.17 CCF46663.1 - 0.061 12.6 0.0 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 Thi4 family 3HCDH_N PF02737.18 CCF46663.1 - 0.066 13.1 0.0 0.098 12.5 0.0 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain F420_oxidored PF03807.17 CCF46663.1 - 0.1 13.2 0.2 0.17 12.5 0.2 1.4 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Pyr_redox_3 PF13738.6 CCF46663.1 - 0.13 11.5 0.6 0.22 10.8 0.6 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Tab2_like PF06485.11 CCF46663.1 - 0.17 11.4 0.0 0.24 10.9 0.0 1.1 1 0 0 1 1 1 0 RNA-binding protein Tab2/Atab2 SET PF00856.28 CCF46664.1 - 5.7e-22 78.9 0.0 7.1e-22 78.6 0.0 1.1 1 0 0 1 1 1 1 SET domain SAF PF08666.12 CCF46664.1 - 0.11 13.2 0.0 0.89 10.2 0.0 2.3 2 0 0 2 2 2 0 SAF domain HTH_Tnp_Tc5 PF03221.16 CCF46665.1 - 3.8e-10 39.7 0.1 2.6e-09 37.0 0.0 2.2 3 0 0 3 3 3 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 CCF46665.1 - 1.9e-08 33.9 0.0 4.1e-08 32.8 0.0 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_23 PF13384.6 CCF46665.1 - 0.00063 19.5 0.1 0.0018 18.0 0.1 1.8 1 0 0 1 1 1 1 Homeodomain-like domain HTH_30 PF13556.6 CCF46665.1 - 0.0058 16.4 0.0 0.014 15.2 0.0 1.6 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain Fungal_trans PF04082.18 CCF46666.1 - 7.5e-12 44.8 0.0 1.5e-11 43.8 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain PAF-AH_p_II PF03403.13 CCF46667.1 - 4.9e-49 166.8 0.0 1.8e-23 82.7 0.0 3.1 3 0 0 3 3 3 2 Platelet-activating factor acetylhydrolase, isoform II Chlorophyllase2 PF12740.7 CCF46667.1 - 1.1e-07 31.0 0.0 2.1e-06 26.9 0.0 2.1 2 0 0 2 2 2 1 Chlorophyllase enzyme Chlorophyllase PF07224.11 CCF46667.1 - 5e-06 25.8 0.0 7.3e-05 21.9 0.0 2.1 2 0 0 2 2 2 1 Chlorophyllase Hydrolase_4 PF12146.8 CCF46667.1 - 0.00026 20.3 0.0 0.13 11.5 0.0 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CCF46667.1 - 0.0027 18.4 0.6 0.016 15.8 0.2 2.2 2 0 0 2 2 2 1 Alpha/beta hydrolase family Methyltransf_25 PF13649.6 CCF46670.1 - 2.3e-15 57.0 0.0 4.5e-15 56.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF46670.1 - 6.4e-15 55.6 0.0 1.3e-14 54.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF46670.1 - 1.4e-11 44.4 0.0 2.2e-11 43.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 CCF46670.1 - 6.7e-09 35.4 0.0 8.8e-09 35.0 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.6 CCF46670.1 - 1.1e-07 31.8 0.0 1.6e-07 31.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF46670.1 - 7.7e-07 29.8 0.0 1.7e-06 28.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CCF46670.1 - 0.00017 21.2 0.0 0.00026 20.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.18 CCF46670.1 - 0.00022 20.7 0.0 0.00031 20.2 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MetW PF07021.12 CCF46670.1 - 0.00036 20.2 0.0 0.00056 19.6 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW TehB PF03848.14 CCF46670.1 - 0.00047 19.6 0.0 0.0015 18.0 0.0 1.7 2 0 0 2 2 2 1 Tellurite resistance protein TehB PrmA PF06325.13 CCF46670.1 - 0.0012 18.3 0.0 0.0018 17.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) PCMT PF01135.19 CCF46670.1 - 0.0046 16.7 0.0 0.0064 16.3 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_32 PF13679.6 CCF46670.1 - 0.0065 16.5 0.0 0.011 15.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltr_RsmB-F PF01189.17 CCF46670.1 - 0.034 13.8 0.0 0.056 13.1 0.0 1.2 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F DOT1 PF08123.13 CCF46670.1 - 0.14 11.7 0.0 0.21 11.1 0.0 1.2 1 0 0 1 1 1 0 Histone methylation protein DOT1 Methyltransf_4 PF02390.17 CCF46670.1 - 0.16 11.4 0.0 0.25 10.8 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase CN_hydrolase PF00795.22 CCF46673.1 - 2.5e-61 207.3 0.0 2.9e-61 207.1 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Metallophos PF00149.28 CCF46674.1 - 0.024 15.1 0.1 0.05 14.1 0.1 1.5 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase SH3_10 PF17902.1 CCF46674.1 - 0.15 12.1 0.0 0.17 11.9 0.0 1.1 1 0 0 1 1 1 0 SH3 domain DUF5597 PF18120.1 CCF46675.1 - 3.9e-22 78.8 0.8 4.5e-22 78.6 0.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF5597) DAO PF01266.24 CCF46676.1 - 3e-10 40.2 0.0 3.2e-10 40.1 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CCF46676.1 - 1.5e-05 25.1 0.0 1.6e-05 25.0 0.0 1.1 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain TrkA_N PF02254.18 CCF46676.1 - 9.1e-05 22.7 0.0 9.8e-05 22.6 0.0 1.1 1 0 0 1 1 1 1 TrkA-N domain Pyr_redox PF00070.27 CCF46676.1 - 0.00019 22.0 0.0 0.00019 21.9 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CCF46676.1 - 0.00031 20.1 0.0 0.00031 20.1 0.0 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CCF46676.1 - 0.00057 19.1 0.0 0.00062 19.0 0.0 1.0 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 CCF46676.1 - 0.0012 18.2 0.0 0.0013 18.1 0.0 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 CCF46676.1 - 0.0017 17.7 0.0 0.0017 17.7 0.0 1.0 1 0 0 1 1 1 1 FAD binding domain Sacchrp_dh_NADP PF03435.18 CCF46676.1 - 0.0036 17.5 0.1 0.0038 17.5 0.1 1.1 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Thi4 PF01946.17 CCF46676.1 - 0.0079 15.5 0.0 0.0091 15.3 0.0 1.0 1 0 0 1 1 1 1 Thi4 family Shikimate_DH PF01488.20 CCF46676.1 - 0.009 16.1 0.0 0.01 15.9 0.0 1.1 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_9 PF13454.6 CCF46676.1 - 0.0094 15.9 0.1 0.01 15.8 0.1 1.0 1 0 0 1 1 1 1 FAD-NAD(P)-binding Lycopene_cycl PF05834.12 CCF46676.1 - 0.016 14.3 0.1 0.018 14.1 0.1 1.0 1 0 0 1 1 1 0 Lycopene cyclase protein ApbA PF02558.16 CCF46676.1 - 0.019 14.6 0.0 0.019 14.6 0.0 1.1 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA ThiF PF00899.21 CCF46676.1 - 0.043 13.2 0.1 0.052 12.9 0.1 1.0 1 0 0 1 1 1 0 ThiF family K_oxygenase PF13434.6 CCF46676.1 - 0.044 12.9 0.0 0.049 12.8 0.0 1.0 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) 3HCDH_N PF02737.18 CCF46676.1 - 0.052 13.4 0.0 0.052 13.4 0.0 1.0 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.23 CCF46676.1 - 0.058 13.4 0.0 0.058 13.4 0.0 1.1 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus F420_oxidored PF03807.17 CCF46676.1 - 0.16 12.6 0.0 0.16 12.5 0.0 1.1 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent HI0933_like PF03486.14 CCF46676.1 - 0.17 10.6 0.0 0.19 10.4 0.0 1.0 1 0 0 1 1 1 0 HI0933-like protein TSNR_N PF04705.12 CCF46677.1 - 0.13 12.3 0.0 0.16 12.0 0.0 1.2 1 0 0 1 1 1 0 Thiostrepton-resistance methylase, N terminus GDP_Man_Dehyd PF16363.5 CCF46678.1 - 2.7e-33 115.8 0.2 3.1e-33 115.6 0.2 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 CCF46678.1 - 1.3e-24 87.1 0.1 1.5e-24 86.8 0.1 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 CCF46678.1 - 2e-18 66.6 0.0 2.5e-18 66.3 0.0 1.0 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 CCF46678.1 - 8.6e-14 51.2 0.0 1e-13 51.0 0.0 1.0 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 CCF46678.1 - 3.3e-09 36.3 0.4 8.7e-08 31.6 0.4 2.1 1 1 0 1 1 1 1 Male sterility protein RmlD_sub_bind PF04321.17 CCF46678.1 - 2.8e-07 30.0 0.0 3.5e-07 29.6 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 CCF46678.1 - 0.00028 20.8 0.0 0.00041 20.3 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 CCF46678.1 - 0.08 12.8 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 KR domain RNA_pol_A_CTD PF03118.15 CCF46678.1 - 0.14 11.9 0.0 0.26 11.1 0.0 1.4 1 0 0 1 1 1 0 Bacterial RNA polymerase, alpha chain C terminal domain 3HCDH PF00725.22 CCF46680.1 - 1.4e-15 57.7 0.0 1.9e-15 57.2 0.0 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain MEDS PF14417.6 CCF46680.1 - 0.082 12.7 0.0 0.11 12.4 0.0 1.1 1 0 0 1 1 1 0 MEDS: MEthanogen/methylotroph, DcmR Sensory domain NmrA PF05368.13 CCF46681.1 - 1.5e-40 139.3 0.0 1.8e-40 138.9 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family Ribosomal_60s PF00428.19 CCF46681.1 - 1.2 9.8 6.7 2.7 8.6 6.7 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein Ribonucleas_3_3 PF14622.6 CCF46682.1 - 1.8e-27 96.1 0.0 2.6e-27 95.5 0.0 1.3 1 0 0 1 1 1 1 Ribonuclease-III-like Htr2 PF17909.1 CCF46682.1 - 0.037 14.3 0.7 0.088 13.1 0.7 1.6 1 0 0 1 1 1 0 Htr2 transmembrane domain GcrA PF07750.11 CCF46683.1 - 0.043 14.2 0.0 0.051 14.0 0.0 1.2 1 0 0 1 1 1 0 GcrA cell cycle regulator Condensation PF00668.20 CCF46685.1 - 9e-76 255.4 0.0 1.2e-75 254.9 0.0 1.2 1 0 0 1 1 1 1 Condensation domain AMP-binding PF00501.28 CCF46685.1 - 9.2e-71 238.6 0.0 1.6e-70 237.8 0.0 1.4 1 0 0 1 1 1 1 AMP-binding enzyme PS-DH PF14765.6 CCF46685.1 - 1.2e-47 162.6 0.2 3.2e-47 161.2 0.2 1.8 1 0 0 1 1 1 1 Polyketide synthase dehydratase KR PF08659.10 CCF46685.1 - 5e-47 160.1 0.3 2.2e-46 158.0 0.1 2.1 2 0 0 2 2 2 1 KR domain NAD_binding_4 PF07993.12 CCF46685.1 - 2.6e-22 79.2 0.1 4.3e-21 75.2 0.1 2.3 1 1 0 1 1 1 1 Male sterility protein PP-binding PF00550.25 CCF46685.1 - 4.4e-19 68.6 0.3 2.1e-11 44.0 0.0 2.8 2 0 0 2 2 2 2 Phosphopantetheine attachment site Methyltransf_12 PF08242.12 CCF46685.1 - 6.4e-17 62.1 0.0 2e-16 60.5 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Acyl_transf_1 PF00698.21 CCF46685.1 - 4.6e-13 49.4 0.0 8.8e-13 48.4 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain adh_short PF00106.25 CCF46685.1 - 3e-12 46.4 0.0 9.6e-12 44.8 0.0 1.8 2 0 0 2 2 2 1 short chain dehydrogenase Methyltransf_25 PF13649.6 CCF46685.1 - 2.3e-10 41.0 0.0 8.3e-10 39.2 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF46685.1 - 6.4e-10 39.5 0.0 2.2e-09 37.9 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF46685.1 - 2.1e-09 37.4 0.0 1.3e-08 34.8 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF46685.1 - 1.5e-08 34.7 0.0 3.7e-08 33.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain adh_short_C2 PF13561.6 CCF46685.1 - 4.7e-06 26.3 0.3 1.1e-05 25.1 0.1 1.7 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 CCF46685.1 - 1e-05 25.2 0.0 0.00098 18.7 0.0 2.8 3 0 0 3 3 3 1 NAD dependent epimerase/dehydratase family Ubie_methyltran PF01209.18 CCF46685.1 - 1.9e-05 24.1 0.0 4.3e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family NAD_binding_10 PF13460.6 CCF46685.1 - 0.00076 19.4 0.9 0.0028 17.6 0.0 2.4 3 0 0 3 3 2 1 NAD(P)H-binding 3Beta_HSD PF01073.19 CCF46685.1 - 0.00089 18.3 0.0 0.0021 17.1 0.0 1.6 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Methyltransf_16 PF10294.9 CCF46685.1 - 0.0096 15.7 0.0 0.026 14.3 0.0 1.7 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_8 PF05148.15 CCF46685.1 - 0.089 12.6 0.0 0.27 11.0 0.0 1.7 2 0 0 2 2 2 0 Hypothetical methyltransferase Semialdhyde_dh PF01118.24 CCF46685.1 - 0.14 12.6 0.0 0.53 10.7 0.0 2.0 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain PhoD PF09423.10 CCF46686.1 - 4.8e-05 22.5 0.3 0.00063 18.9 0.3 2.1 1 1 0 1 1 1 1 PhoD-like phosphatase FPN1 PF06963.12 CCF46687.1 - 1.1e-104 350.5 5.5 1.2e-104 350.3 5.5 1.0 1 0 0 1 1 1 1 Ferroportin1 (FPN1) Methyltransf_2 PF00891.18 CCF46688.1 - 4.6e-23 81.6 0.0 6.9e-23 81.1 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_31 PF13847.6 CCF46688.1 - 0.0018 18.1 0.0 0.003 17.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF46688.1 - 0.019 15.7 0.0 0.055 14.2 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_16 PF10294.9 CCF46688.1 - 0.054 13.2 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_12 PF08242.12 CCF46688.1 - 0.069 13.9 0.0 0.18 12.5 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain TMEM51 PF15345.6 CCF46689.1 - 0.0072 16.2 0.0 0.009 15.9 0.0 1.1 1 0 0 1 1 1 1 Transmembrane protein 51 Na_H_antiport_1 PF06965.12 CCF46689.1 - 0.06 12.2 0.0 0.067 12.0 0.0 1.0 1 0 0 1 1 1 0 Na+/H+ antiporter 1 Comm PF15957.5 CCF46689.1 - 0.12 12.8 0.0 0.16 12.3 0.0 1.2 1 0 0 1 1 1 0 Commissureless DUF2407_C PF13373.6 CCF46689.1 - 0.2 11.9 0.0 0.34 11.1 0.0 1.4 1 0 0 1 1 1 0 DUF2407 C-terminal domain Cyanate_lyase PF02560.14 CCF46692.1 - 2.5e-32 110.5 0.0 3.5e-32 110.1 0.0 1.2 1 0 0 1 1 1 1 Cyanate lyase C-terminal domain HTH_31 PF13560.6 CCF46692.1 - 0.00074 19.8 0.0 0.0011 19.2 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_38 PF13936.6 CCF46692.1 - 0.16 11.8 0.0 0.35 10.7 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain Lipase_GDSL_2 PF13472.6 CCF46695.1 - 1.3e-21 77.8 0.1 1.7e-21 77.4 0.1 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 CCF46695.1 - 7.5e-11 42.4 0.0 9.9e-11 42.0 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase ketoacyl-synt PF00109.26 CCF46696.1 - 6.2e-70 235.7 0.0 1.4e-69 234.5 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain SAT PF16073.5 CCF46696.1 - 4.6e-54 183.7 0.0 1.5e-52 178.7 0.0 2.8 2 0 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Acyl_transf_1 PF00698.21 CCF46696.1 - 1.3e-39 136.5 0.1 2.3e-39 135.8 0.1 1.3 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 CCF46696.1 - 6.8e-35 119.6 1.3 2.5e-34 117.8 1.3 2.1 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PP-binding PF00550.25 CCF46696.1 - 4.3e-22 78.3 2.7 7.7e-13 48.6 0.1 2.7 2 0 0 2 2 2 2 Phosphopantetheine attachment site PS-DH PF14765.6 CCF46696.1 - 1.8e-18 66.8 0.0 3.2e-18 66.0 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase KAsynt_C_assoc PF16197.5 CCF46696.1 - 2.6e-09 37.5 0.0 1e-08 35.6 0.0 2.1 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Thiolase_N PF00108.23 CCF46696.1 - 0.011 15.1 0.1 0.011 15.1 0.1 2.1 2 0 0 2 2 2 0 Thiolase, N-terminal domain ketoacyl-synt PF00109.26 CCF46697.1 - 2e-59 201.2 0.4 2.9e-59 200.7 0.4 1.2 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 CCF46697.1 - 2.2e-38 130.9 0.1 6.9e-38 129.3 0.1 1.8 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 CCF46697.1 - 6.2e-20 71.7 0.0 1.3e-19 70.7 0.0 1.6 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Acyl_transf_1 PF00698.21 CCF46697.1 - 8.3e-09 35.4 0.1 1.3e-08 34.7 0.1 1.3 1 0 0 1 1 1 1 Acyl transferase domain Thiolase_N PF00108.23 CCF46697.1 - 7e-08 32.2 0.2 1.3e-07 31.2 0.2 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain Zn_clus PF00172.18 CCF46698.1 - 2.3e-09 37.2 12.8 3.2e-09 36.8 12.8 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Vps39_2 PF10367.9 CCF46698.1 - 0.017 15.5 2.6 0.02 15.3 2.6 1.2 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 DUF3237 PF11578.8 CCF46699.1 - 1e-17 64.4 0.0 1.2e-17 64.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3237) Ras PF00071.22 CCF46701.1 - 1.1e-51 174.6 0.0 1.4e-51 174.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCF46701.1 - 8.5e-20 71.2 0.0 1.4e-19 70.5 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCF46701.1 - 1.6e-11 44.0 0.0 1.9e-11 43.7 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 CCF46701.1 - 1.6e-05 24.5 0.3 0.00012 21.6 0.3 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 CCF46701.1 - 0.00013 21.9 0.0 0.51 10.2 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 CCF46701.1 - 0.00029 20.9 0.0 0.00058 19.9 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_33 PF13671.6 CCF46701.1 - 0.0056 16.8 0.0 0.01 16.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain NB-ARC PF00931.22 CCF46701.1 - 0.028 13.6 0.0 0.04 13.1 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_16 PF13191.6 CCF46701.1 - 0.052 13.9 0.0 0.23 11.9 0.0 2.0 2 1 1 3 3 3 0 AAA ATPase domain Scytalone_dh PF02982.14 CCF46701.1 - 0.068 13.0 0.0 0.18 11.6 0.0 1.6 2 0 0 2 2 2 0 Scytalone dehydratase AAA_22 PF13401.6 CCF46701.1 - 0.12 12.6 0.1 1.6 9.0 0.1 2.5 2 1 0 2 2 2 0 AAA domain SH3_9 PF14604.6 CCF46705.1 - 1.8e-21 75.7 0.7 1.9e-13 50.0 0.0 2.3 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 CCF46705.1 - 1.7e-13 49.9 0.1 1.2e-05 24.8 0.0 2.2 2 0 0 2 2 2 2 SH3 domain SH3_3 PF08239.11 CCF46705.1 - 4.2e-05 23.7 0.3 0.027 14.8 0.1 2.6 2 0 0 2 2 2 2 Bacterial SH3 domain SH3_10 PF17902.1 CCF46705.1 - 0.00065 19.7 0.0 0.14 12.3 0.0 2.3 2 0 0 2 2 2 2 SH3 domain SH3_16 PF18348.1 CCF46705.1 - 0.0093 15.8 0.0 1.5 8.7 0.0 2.3 2 0 0 2 2 2 2 Bacterial dipeptidyl-peptidase Sh3 domain SH3_2 PF07653.17 CCF46705.1 - 0.03 14.0 0.1 3.6 7.4 0.0 2.2 2 0 0 2 2 2 0 Variant SH3 domain Elong_Iki1 PF10483.9 CCF46707.1 - 2.1e-107 359.1 0.0 2.4e-107 358.9 0.0 1.0 1 0 0 1 1 1 1 Elongator subunit Iki1 NACHT PF05729.12 CCF46707.1 - 0.23 11.4 2.0 1.3 8.9 2.0 2.0 1 1 0 1 1 1 0 NACHT domain ASXH PF13919.6 CCF46708.1 - 5e-40 136.7 0.3 9.1e-40 135.9 0.3 1.4 1 0 0 1 1 1 1 Asx homology domain DUF3433 PF11915.8 CCF46709.1 - 1.1e-29 102.7 3.4 4.5e-17 62.3 0.7 3.7 3 0 0 3 3 3 2 Protein of unknown function (DUF3433) PP-binding PF00550.25 CCF46710.1 - 1.5e-09 38.1 0.2 1.7e-09 37.9 0.2 1.1 1 0 0 1 1 1 1 Phosphopantetheine attachment site CDC45 PF02724.14 CCF46713.1 - 0.97 7.6 9.3 1 7.5 9.3 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF4770 PF15994.5 CCF46713.1 - 1.4 9.1 6.0 1.9 8.7 6.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) Polysacc_deac_1 PF01522.21 CCF46715.1 - 2.6e-28 98.4 0.0 4.3e-28 97.7 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase Chitin_bind_1 PF00187.19 CCF46715.1 - 2.7e-06 27.8 16.3 5.3e-06 26.8 16.3 1.5 1 0 0 1 1 1 1 Chitin recognition protein DUF2334 PF10096.9 CCF46715.1 - 0.0091 15.7 0.1 0.012 15.3 0.1 1.2 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2334) Glyco_hydro_57 PF03065.15 CCF46715.1 - 0.099 11.8 0.0 0.16 11.1 0.0 1.5 1 1 0 1 1 1 0 Glycosyl hydrolase family 57 Peroxidase_2 PF01328.17 CCF46716.1 - 1.8e-47 162.3 0.0 2.3e-47 161.9 0.0 1.1 1 0 0 1 1 1 1 Peroxidase, family 2 GIT_SHD PF08518.11 CCF46718.1 - 5.9e-23 80.2 5.7 2.4e-11 43.1 2.4 2.8 2 0 0 2 2 2 2 Spa2 homology domain (SHD) of GIT ATP-grasp_4 PF13535.6 CCF46718.1 - 0.17 11.5 0.2 3.2 7.3 0.2 2.7 2 0 0 2 2 2 0 ATP-grasp domain PSII_Pbs27 PF13326.6 CCF46718.1 - 0.54 10.6 12.1 4.8 7.5 3.5 3.1 1 1 0 2 2 2 0 Photosystem II Pbs27 DUF1843 PF08898.10 CCF46718.1 - 0.71 10.4 3.5 0.65 10.5 0.2 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1843) DUF4686 PF15742.5 CCF46718.1 - 1.1 8.4 38.4 42 3.1 3.5 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4686) HetR_C PF18460.1 CCF46718.1 - 1.5 8.8 4.6 3.6 7.6 0.1 3.0 3 0 0 3 3 3 0 Heterocyst differentiation regulator C-terminal Hood domain CLZ PF16526.5 CCF46718.1 - 1.8 9.0 19.8 0.077 13.4 1.2 4.0 3 0 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels THP2 PF09432.10 CCF46718.1 - 3.5 7.7 12.4 0.19 11.7 4.0 2.7 1 1 1 2 2 2 0 Tho complex subunit THP2 UPF0242 PF06785.11 CCF46718.1 - 5 7.2 34.4 9.7 6.2 17.3 2.6 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus CALCOCO1 PF07888.11 CCF46718.1 - 9.2 5.0 43.9 6.1 5.6 11.0 2.2 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like Glyco_hydro_15 PF00723.21 CCF46720.1 - 1.9e-43 148.9 0.0 5.6e-41 140.8 0.0 2.0 1 1 0 1 1 1 1 Glycosyl hydrolases family 15 PikAIV_N PF18605.1 CCF46721.1 - 0.0093 15.5 0.3 0.016 14.7 0.3 1.3 1 0 0 1 1 1 1 Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain NUDE_C PF04880.13 CCF46722.1 - 2.5e-38 132.3 20.1 2.5e-38 132.3 20.1 5.3 2 2 3 6 6 2 1 NUDE protein, C-terminal conserved region Alanine_zipper PF11839.8 CCF46722.1 - 0.00075 19.8 7.1 0.00075 19.8 7.1 2.2 2 0 0 2 2 2 1 Alanine-zipper, major outer membrane lipoprotein ZapB PF06005.12 CCF46722.1 - 0.0031 17.9 10.4 0.0031 17.9 10.4 4.9 2 1 3 5 5 5 1 Cell division protein ZapB ATG16 PF08614.11 CCF46722.1 - 0.0055 17.0 18.7 0.0055 17.0 18.7 3.4 2 1 1 3 3 3 1 Autophagy protein 16 (ATG16) PSII_Pbs27 PF13326.6 CCF46722.1 - 0.0094 16.3 4.1 0.023 15.0 4.1 1.7 1 0 0 1 1 1 1 Photosystem II Pbs27 Tropomyosin_1 PF12718.7 CCF46722.1 - 0.11 12.6 40.8 0.08 13.1 17.4 4.6 2 1 2 4 4 4 0 Tropomyosin like CENP-F_leu_zip PF10473.9 CCF46722.1 - 0.12 12.4 39.9 0.064 13.3 18.0 4.0 2 1 2 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Fez1 PF06818.15 CCF46722.1 - 0.26 11.7 32.4 0.12 12.8 14.7 3.0 2 1 1 3 3 3 0 Fez1 YjbH PF06082.11 CCF46722.1 - 0.35 9.6 8.7 0.52 9.1 8.7 1.2 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH ERM PF00769.19 CCF46722.1 - 0.46 10.3 38.0 0.19 11.5 18.3 2.4 2 1 1 3 3 3 0 Ezrin/radixin/moesin family Filament PF00038.21 CCF46722.1 - 1.5 8.3 34.7 22 4.5 32.8 2.7 2 1 0 2 2 2 0 Intermediate filament protein FPP PF05911.11 CCF46722.1 - 3 5.9 35.4 0.056 11.6 16.9 2.4 2 1 1 3 3 3 0 Filament-like plant protein, long coiled-coil DUF948 PF06103.11 CCF46722.1 - 3.3 8.0 4.5 6.5 7.1 1.4 2.7 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) ADIP PF11559.8 CCF46722.1 - 4.4 7.4 37.2 0.89 9.6 15.6 3.7 2 1 2 4 4 4 0 Afadin- and alpha -actinin-Binding Tho2 PF11262.8 CCF46722.1 - 4.9 6.3 21.7 1.1 8.4 4.5 2.3 2 0 0 2 2 2 0 Transcription factor/nuclear export subunit protein 2 IFT57 PF10498.9 CCF46722.1 - 5.7 5.8 27.3 0.071 12.1 12.4 2.2 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 Atg14 PF10186.9 CCF46722.1 - 7.3 5.6 34.1 0.79 8.7 15.1 3.0 2 1 1 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 LPP PF04728.13 CCF46722.1 - 9.3 6.7 9.4 36 4.9 2.4 3.8 3 2 0 3 3 3 0 Lipoprotein leucine-zipper Glyco_hyd_65N_2 PF14498.6 CCF46724.1 - 2.3e-57 194.6 0.0 3.4e-57 194.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain Sugar_tr PF00083.24 CCF46725.1 - 1.6e-05 24.0 2.3 2.1e-05 23.6 2.2 1.3 1 1 0 1 1 1 1 Sugar (and other) transporter NPP1 PF05630.11 CCF46728.1 - 8e-65 218.6 0.0 9.2e-65 218.4 0.0 1.0 1 0 0 1 1 1 1 Necrosis inducing protein (NPP1) HisG PF01634.18 CCF46732.1 - 1.5e-55 187.5 0.1 2.5e-55 186.8 0.1 1.4 1 0 0 1 1 1 1 ATP phosphoribosyltransferase HisG_C PF08029.11 CCF46732.1 - 3.2e-28 97.7 0.1 9.9e-28 96.1 0.1 1.9 1 0 0 1 1 1 1 HisG, C-terminal domain SelR PF01641.18 CCF46733.1 - 8.3e-49 164.7 0.1 1e-48 164.4 0.1 1.1 1 0 0 1 1 1 1 SelR domain zinc_ribbon_10 PF10058.9 CCF46733.1 - 0.088 12.5 0.1 1.4 8.7 0.0 2.2 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein Yippee-Mis18 PF03226.14 CCF46733.1 - 0.1 12.8 0.3 0.31 11.3 0.3 1.8 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DZR PF12773.7 CCF46733.1 - 0.5 10.4 3.8 3.2 7.8 2.8 2.2 1 1 1 2 2 2 0 Double zinc ribbon Pterin_bind PF00809.22 CCF46736.1 - 1.2e-67 228.2 0.0 2.7e-67 227.0 0.0 1.6 1 1 0 1 1 1 1 Pterin binding enzyme HPPK PF01288.20 CCF46736.1 - 6.1e-29 100.8 0.1 1.8e-28 99.3 0.0 1.8 2 0 0 2 2 2 1 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) NMO PF03060.15 CCF46737.1 - 1.3e-54 185.8 0.4 2.2e-54 185.1 0.4 1.3 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 CCF46737.1 - 3.3e-11 42.8 0.8 5.2e-11 42.1 0.8 1.3 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 CCF46737.1 - 2.2e-05 23.7 2.1 3.2e-05 23.1 2.1 1.2 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Glu_synthase PF01645.17 CCF46737.1 - 0.0033 16.6 0.9 0.0068 15.6 0.9 1.5 1 0 0 1 1 1 1 Conserved region in glutamate synthase DHO_dh PF01180.21 CCF46737.1 - 0.026 13.8 0.1 0.04 13.1 0.1 1.3 1 0 0 1 1 1 0 Dihydroorotate dehydrogenase ArfGap PF01412.18 CCF46738.1 - 5.9e-31 107.0 0.1 1.1e-30 106.1 0.1 1.5 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf HET PF06985.11 CCF46739.1 - 1.9e-12 47.7 1.7 1.6e-08 35.0 0.3 2.4 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) zf-MYND PF01753.18 CCF46740.1 - 1.1e-10 41.4 16.2 2.1e-10 40.5 16.2 1.5 1 0 0 1 1 1 1 MYND finger DUF4470 PF14737.6 CCF46740.1 - 9e-10 38.6 0.1 6.4e-08 32.7 0.1 2.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4470) zf-C6H2 PF15801.5 CCF46740.1 - 0.36 11.2 8.1 1 9.7 8.1 1.8 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding zinc_ribbon_2 PF13240.6 CCF46740.1 - 1.7 8.5 6.9 4.3 7.2 6.9 1.8 1 0 0 1 1 1 0 zinc-ribbon domain AMP-binding PF00501.28 CCF46742.1 - 1e-29 103.4 0.0 5.5e-29 101.0 0.0 1.8 2 0 0 2 2 2 1 AMP-binding enzyme HET PF06985.11 CCF46743.1 - 1.5e-07 31.8 0.1 3.9e-05 24.0 0.1 2.6 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Apolipoprotein PF01442.18 CCF46744.1 - 0.00047 20.1 1.2 0.0006 19.7 1.2 1.2 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain CsbD PF05532.12 CCF46744.1 - 0.0069 16.3 22.7 0.36 10.8 13.8 3.3 1 1 1 2 2 2 2 CsbD-like LEA_4 PF02987.16 CCF46744.1 - 0.014 15.5 8.7 0.014 15.5 8.7 2.3 1 1 1 2 2 2 0 Late embryogenesis abundant protein DUF883 PF05957.13 CCF46744.1 - 0.06 14.0 3.1 0.14 12.8 1.5 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) YtxH PF12732.7 CCF46744.1 - 0.095 13.3 11.9 18 6.0 11.9 2.3 1 1 0 1 1 1 0 YtxH-like protein ApoLp-III PF07464.11 CCF46744.1 - 0.31 11.1 6.3 0.69 10.0 6.3 1.6 1 1 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) Hira PF07569.11 CCF46745.1 - 1.4e-85 286.6 0.0 2.2e-85 285.9 0.0 1.3 1 0 0 1 1 1 1 TUP1-like enhancer of split Glyco_hydro_7 PF00840.20 CCF46746.1 - 2.6e-57 194.5 0.0 2.9e-57 194.4 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 7 ADH_N PF08240.12 CCF46747.1 - 1.3e-25 89.4 2.1 2.4e-25 88.5 2.1 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_N_assoc PF13823.6 CCF46747.1 - 4.8e-10 39.2 0.3 1.3e-09 37.8 0.3 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-associated ADH_zinc_N PF00107.26 CCF46747.1 - 0.009 16.0 0.0 0.021 14.8 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase COQ7 PF03232.13 CCF46748.1 - 1.4e-71 239.8 0.3 1.7e-71 239.5 0.3 1.1 1 0 0 1 1 1 1 Ubiquinone biosynthesis protein COQ7 Rubrerythrin PF02915.17 CCF46748.1 - 0.00017 22.0 0.1 0.00062 20.2 0.0 1.8 1 1 0 2 2 2 1 Rubrerythrin Vitellogenin_N PF01347.22 CCF46748.1 - 0.016 13.6 0.0 0.016 13.6 0.0 1.1 1 0 0 1 1 1 0 Lipoprotein amino terminal region DUF724 PF05266.14 CCF46748.1 - 0.21 11.4 0.4 0.44 10.4 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF724) Phe_hydrox_dim PF07976.12 CCF46751.1 - 1.2e-47 162.0 0.0 1.7e-47 161.5 0.0 1.2 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain Peptidase_C50 PF03568.17 CCF46752.1 - 5.9e-160 532.7 0.0 4.6e-159 529.8 0.0 2.1 2 0 0 2 2 2 1 Peptidase family C50 TPR_12 PF13424.6 CCF46752.1 - 1.2e-07 31.9 16.3 0.073 13.4 0.3 5.6 4 2 2 6 6 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 CCF46752.1 - 5e-05 23.1 3.2 5 7.5 0.1 5.7 5 0 0 5 5 5 1 Tetratricopeptide repeat RPN7 PF10602.9 CCF46752.1 - 8.1e-05 22.4 0.6 0.19 11.4 0.0 3.6 2 2 1 3 3 3 2 26S proteasome subunit RPN7 CHAT PF12770.7 CCF46752.1 - 0.0012 18.3 3.8 0.025 14.0 0.0 3.7 4 0 0 4 4 4 1 CHAT domain TPR_7 PF13176.6 CCF46752.1 - 0.0062 16.5 0.1 3.9 7.7 0.0 3.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 CCF46752.1 - 0.039 14.6 0.1 0.79 10.4 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 CCF46752.1 - 0.23 11.7 0.0 0.23 11.7 0.0 3.7 4 0 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 CCF46752.1 - 0.26 11.2 2.5 82 3.3 0.1 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.6 CCF46752.1 - 2 8.8 7.1 2.4 8.6 0.2 4.3 5 0 0 5 5 3 0 Tetratricopeptide repeat TPR_4 PF07721.14 CCF46752.1 - 3 8.7 5.5 6.5 7.7 0.0 4.3 4 0 0 4 4 3 0 Tetratricopeptide repeat Myosin-VI_CBD PF16521.5 CCF46753.1 - 0.054 13.5 0.6 0.077 13.0 0.6 1.2 1 0 0 1 1 1 0 Myosin VI cargo binding domain MFS_1 PF07690.16 CCF46754.1 - 8.6e-11 41.4 0.3 1e-10 41.1 0.3 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily SLATT_6 PF18169.1 CCF46755.1 - 0.059 13.0 0.0 0.1 12.2 0.0 1.3 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 6 OPT PF03169.15 CCF46757.1 - 1.5e-29 103.2 4.1 1.9e-29 102.8 4.1 1.2 1 0 0 1 1 1 1 OPT oligopeptide transporter protein 2TM PF13239.6 CCF46757.1 - 0.73 10.2 4.8 4.6 7.6 0.0 2.3 2 0 0 2 2 2 0 2TM domain Ferlin_C PF16165.5 CCF46757.1 - 3.2 7.7 4.7 6.8 6.6 4.7 1.5 1 0 0 1 1 1 0 Ferlin C-terminus Clp1 PF06807.14 CCF46758.1 - 1.7e-25 89.7 0.0 6.4e-25 87.8 0.0 1.9 1 1 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 CLP1_P PF16575.5 CCF46758.1 - 2.9e-12 46.8 0.0 4.6e-12 46.1 0.0 1.3 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop ENTH PF01417.20 CCF46759.1 - 2.6e-50 169.6 0.1 4.8e-50 168.8 0.1 1.4 1 0 0 1 1 1 1 ENTH domain DUF1720 PF08226.11 CCF46759.1 - 4.5e-07 30.2 46.7 4.5e-07 30.2 46.7 5.3 2 1 1 3 3 3 1 Domain of unknown function (DUF1720) UIM PF02809.20 CCF46759.1 - 9.9e-05 22.0 2.9 0.0024 17.7 0.2 2.7 2 0 0 2 2 2 1 Ubiquitin interaction motif ANTH PF07651.16 CCF46759.1 - 0.004 16.2 0.0 0.0061 15.6 0.0 1.2 1 0 0 1 1 1 1 ANTH domain VHS PF00790.19 CCF46759.1 - 0.031 14.1 0.0 0.059 13.2 0.0 1.4 1 0 0 1 1 1 0 VHS domain DUF4264 PF14084.6 CCF46759.1 - 0.11 12.2 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4264) Nucleoporin2 PF04096.14 CCF46760.1 - 3.1e-51 173.4 0.0 5.5e-51 172.6 0.0 1.4 1 0 0 1 1 1 1 Nucleoporin autopeptidase Nup96 PF12110.8 CCF46760.1 - 6.6e-25 87.8 0.5 2.2e-24 86.1 0.0 1.9 2 0 0 2 2 2 1 Nuclear protein 96 Nucleoporin_FG PF13634.6 CCF46760.1 - 1.6e-11 44.9 365.3 0.00026 21.8 32.9 12.3 2 2 10 12 12 12 6 Nucleoporin FG repeat region Polysacc_deac_1 PF01522.21 CCF46761.1 - 6.6e-25 87.4 0.0 9.4e-25 86.9 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.15 CCF46761.1 - 0.015 14.5 0.0 0.021 14.0 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 57 Corona_NS8 PF12093.8 CCF46761.1 - 0.11 13.0 0.0 3.5 8.2 0.0 2.3 2 0 0 2 2 2 0 Coronavirus NS8 protein FAD_binding_4 PF01565.23 CCF46762.1 - 2.7e-28 98.5 0.3 7.3e-28 97.0 0.1 1.7 2 0 0 2 2 2 1 FAD binding domain ALO PF04030.14 CCF46762.1 - 5.8e-23 82.0 0.2 8.6e-23 81.5 0.2 1.3 1 0 0 1 1 1 1 D-arabinono-1,4-lactone oxidase RasGAP PF00616.19 CCF46765.1 - 0.12 12.1 0.5 0.2 11.4 0.5 1.4 1 0 0 1 1 1 0 GTPase-activator protein for Ras-like GTPase zf-PARP PF00645.18 CCF46767.1 - 1.1e-19 71.1 0.7 2.4e-19 69.9 0.7 1.6 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region SKG6 PF08693.10 CCF46770.1 - 0.0014 18.0 1.4 0.0032 16.9 1.4 1.6 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Rax2 PF12768.7 CCF46770.1 - 0.0016 17.9 0.6 0.0029 17.1 0.2 1.5 1 1 1 2 2 2 1 Cortical protein marker for cell polarity Gram_pos_anchor PF00746.21 CCF46770.1 - 0.077 12.9 1.3 0.15 12.1 1.3 1.4 1 0 0 1 1 1 0 LPXTG cell wall anchor motif Nitrate_red_gam PF02665.14 CCF46770.1 - 0.11 12.1 0.3 0.14 11.6 0.3 1.1 1 0 0 1 1 1 0 Nitrate reductase gamma subunit IBN_N PF03810.19 CCF46771.1 - 1.3e-08 34.6 0.2 4.6e-08 32.9 0.1 2.1 2 0 0 2 2 2 1 Importin-beta N-terminal domain Xpo1 PF08389.12 CCF46771.1 - 3.5e-06 27.1 0.1 1e-05 25.7 0.1 1.7 1 1 0 1 1 1 1 Exportin 1-like protein GRIP PF01465.20 CCF46771.1 - 0.0038 17.1 0.1 0.011 15.6 0.1 1.9 1 1 0 1 1 1 1 GRIP domain DUF1907 PF08925.11 CCF46772.1 - 2.7e-63 214.0 0.0 3.2e-63 213.8 0.0 1.0 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1907) Aminotran_1_2 PF00155.21 CCF46773.1 - 1.7e-59 201.8 0.0 1.9e-59 201.7 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Arf PF00025.21 CCF46775.1 - 3.4e-36 124.3 0.0 3.7e-36 124.2 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 CCF46775.1 - 7.6e-14 51.6 0.0 9.2e-14 51.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCF46775.1 - 1.8e-09 37.9 0.0 2.7e-09 37.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 CCF46775.1 - 2.2e-06 27.1 0.0 2.9e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 G-protein alpha subunit Gtr1_RagA PF04670.12 CCF46775.1 - 2.3e-05 23.9 0.0 2.6e-05 23.7 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 CCF46775.1 - 0.015 14.9 0.0 0.017 14.7 0.0 1.1 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain MMR_HSR1_Xtn PF16897.5 CCF46775.1 - 0.083 12.9 0.0 0.14 12.2 0.0 1.4 1 1 0 1 1 1 0 C-terminal region of MMR_HSR1 domain DNase-RNase PF02577.14 CCF46776.1 - 0.069 12.8 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Bifunctional nuclease HTH_32 PF13565.6 CCF46777.1 - 0.018 15.6 0.0 0.033 14.8 0.0 1.4 1 1 0 1 1 1 0 Homeodomain-like domain DUF3011 PF11218.8 CCF46778.1 - 0.044 13.8 0.0 0.05 13.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3011) Aldose_epim PF01263.20 CCF46779.1 - 5.2e-55 186.9 0.0 6.6e-55 186.5 0.0 1.1 1 0 0 1 1 1 1 Aldose 1-epimerase zf-met2 PF12907.7 CCF46779.1 - 0.24 11.6 0.1 0.69 10.1 0.1 1.7 1 0 0 1 1 1 0 Zinc-binding DUF3767 PF12597.8 CCF46781.1 - 9.3e-39 131.3 0.2 2.1e-38 130.2 0.0 1.6 1 1 1 2 2 2 1 Protein of unknown function (DUF3767) DNA_pol_B_exo1 PF03104.19 CCF46782.1 - 4.3e-81 272.7 1.1 6.8e-81 272.0 1.1 1.3 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_B PF00136.21 CCF46782.1 - 2.2e-15 56.3 0.2 1.3e-12 47.2 0.1 3.1 3 1 0 3 3 3 2 DNA polymerase family B DNA_pol_B_exo2 PF10108.9 CCF46782.1 - 3.8e-09 36.5 0.1 1.1e-08 35.0 0.1 1.8 1 0 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.6 CCF46782.1 - 3.2e-06 27.3 0.3 3e-05 24.1 0.1 2.5 2 1 0 2 2 2 1 RNase_H superfamily Exo84_C PF16528.5 CCF46783.1 - 8.3e-73 244.6 0.0 9.4e-73 244.4 0.0 1.0 1 0 0 1 1 1 1 Exocyst component 84 C-terminal FA_desaturase PF00487.24 CCF46784.1 - 1.7e-08 34.6 7.8 2.2e-08 34.2 7.8 1.1 1 0 0 1 1 1 1 Fatty acid desaturase zf-CCHC PF00098.23 CCF46785.1 - 0.0042 17.1 1.6 0.0042 17.1 1.6 1.8 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_5 PF14787.6 CCF46785.1 - 0.21 11.3 1.3 0.44 10.3 1.3 1.5 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger zf-CCHC_3 PF13917.6 CCF46785.1 - 0.41 10.6 1.3 1.2 9.2 1.3 1.8 1 1 0 1 1 1 0 Zinc knuckle MFS_1 PF07690.16 CCF46787.1 - 3.7e-21 75.4 32.4 5e-21 75.0 32.4 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF4131 PF13567.6 CCF46787.1 - 0.57 9.8 7.9 0.034 13.8 2.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) DUF2929 PF11151.8 CCF46787.1 - 3.4 8.0 9.5 0.27 11.5 0.3 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF2929) Phage_holin_5_2 PF16079.5 CCF46787.1 - 7.3 7.0 14.2 14 6.1 4.3 4.0 3 1 0 3 3 3 0 Phage holin family Hol44, in holin superfamily V GMC_oxred_C PF05199.13 CCF46788.1 - 2.7e-27 96.1 0.0 3e-27 95.9 0.0 1.0 1 0 0 1 1 1 1 GMC oxidoreductase PROCN PF08083.11 CCF46790.1 - 1.6e-233 774.7 9.0 1.6e-233 774.7 9.0 1.9 2 0 0 2 2 2 1 PROCN (NUC071) domain PRP8_domainIV PF12134.8 CCF46790.1 - 4.3e-128 425.7 1.1 9.8e-128 424.5 1.1 1.6 1 0 0 1 1 1 1 PRP8 domain IV core U6-snRNA_bdg PF10596.9 CCF46790.1 - 2.7e-89 297.2 2.0 1.1e-88 295.1 2.0 2.2 1 0 0 1 1 1 1 U6-snRNA interacting domain of PrP8 PRO8NT PF08082.11 CCF46790.1 - 5.4e-77 257.0 3.3 5.4e-77 257.0 3.3 1.9 2 0 0 2 2 2 1 PRO8NT (NUC069), PrP8 N-terminal domain U5_2-snRNA_bdg PF10597.9 CCF46790.1 - 1.6e-71 238.6 0.1 3.4e-71 237.6 0.1 1.6 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 RRM_4 PF10598.9 CCF46790.1 - 1.2e-46 156.9 0.1 3.7e-46 155.4 0.1 1.9 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 PROCT PF08084.11 CCF46790.1 - 3.9e-45 152.7 0.9 8.4e-45 151.7 0.1 2.1 2 0 0 2 2 2 1 PROCT (NUC072) domain MFS_1 PF07690.16 CCF46791.1 - 9.4e-21 74.1 42.4 3.2e-10 39.5 17.8 2.7 2 1 1 3 3 3 2 Major Facilitator Superfamily TRI12 PF06609.13 CCF46791.1 - 4.7e-13 48.4 10.0 4.7e-13 48.4 10.0 1.5 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) PUCC PF03209.15 CCF46791.1 - 0.00051 19.2 8.4 0.00051 19.2 8.4 3.4 1 1 2 3 3 3 1 PUCC protein Pox_A14 PF05767.12 CCF46791.1 - 0.0036 17.4 2.1 0.0036 17.4 2.1 3.2 3 1 0 3 3 3 1 Poxvirus virion envelope protein A14 Glycophorin_A PF01102.18 CCF46791.1 - 0.08 13.2 1.3 9.2 6.5 0.0 3.1 1 1 1 2 2 2 0 Glycophorin A CrgA PF06781.12 CCF46791.1 - 5.5 7.1 7.5 6.4 6.9 0.2 3.9 4 0 0 4 4 4 0 Cell division protein CrgA Zn_clus PF00172.18 CCF46793.1 - 1.3e-07 31.7 6.6 1.6e-07 31.3 6.6 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain GATase PF00117.28 CCF46794.1 - 1.5e-19 70.5 0.0 1.8e-19 70.2 0.0 1.0 1 0 0 1 1 1 1 Glutamine amidotransferase class-I SNO PF01174.19 CCF46794.1 - 2.7e-08 33.9 0.0 2.9e-06 27.3 0.0 2.0 2 0 0 2 2 2 2 SNO glutamine amidotransferase family GATase_3 PF07685.14 CCF46794.1 - 1.6e-05 24.6 0.0 7.7e-05 22.4 0.0 1.8 2 0 0 2 2 2 1 CobB/CobQ-like glutamine amidotransferase domain Peptidase_C26 PF07722.13 CCF46794.1 - 0.052 13.3 0.1 0.66 9.7 0.0 2.0 2 0 0 2 2 2 0 Peptidase C26 mono-CXXC PF15626.6 CCF46795.1 - 0.31 11.4 0.8 0.64 10.4 0.8 1.4 1 0 0 1 1 1 0 single CXXC unit FPN1 PF06963.12 CCF46797.1 - 3.7e-08 32.4 0.0 3.9e-08 32.3 0.0 1.0 1 0 0 1 1 1 1 Ferroportin1 (FPN1) Ig_mannosidase PF17753.1 CCF46797.1 - 0.064 13.0 0.0 0.069 12.9 0.0 1.1 1 0 0 1 1 1 0 Ig-fold domain PQ-loop PF04193.14 CCF46798.1 - 4.7e-25 87.1 3.6 8.1e-12 44.7 0.1 2.8 3 0 0 3 3 3 2 PQ loop repeat PIP5K PF01504.18 CCF46800.1 - 1.1e-101 339.7 0.2 2.1e-101 338.7 0.2 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase COX6B PF02297.17 CCF46801.1 - 2e-23 82.4 5.0 2.8e-23 81.9 5.0 1.2 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb EKLF_TAD2 PF16833.5 CCF46801.1 - 0.044 13.8 0.6 0.095 12.7 0.6 1.6 1 0 0 1 1 1 0 Erythroid krueppel-like transcription factor, transactivation 2 SYS1 PF09801.9 CCF46802.1 - 6.5e-47 159.3 0.3 7.4e-47 159.1 0.3 1.0 1 0 0 1 1 1 1 Integral membrane protein S linking to the trans Golgi network APH PF01636.23 CCF46803.1 - 3.2e-05 24.0 0.1 6.4e-05 23.0 0.0 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family AMP-binding PF00501.28 CCF46804.1 - 3.3e-19 68.8 0.0 3.6e-19 68.7 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme DUF4250 PF14056.6 CCF46805.1 - 0.11 12.5 0.1 0.15 12.1 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4250) AtuA PF07287.11 CCF46806.1 - 2.9e-66 223.6 0.0 3.6e-66 223.3 0.0 1.1 1 0 0 1 1 1 1 Acyclic terpene utilisation family protein AtuA DUF1967 PF09269.11 CCF46808.1 - 0.03 14.3 0.6 6.7 6.7 0.1 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF1967) BRCT PF00533.26 CCF46809.1 - 2.2e-07 31.1 0.0 4.9e-07 30.0 0.0 1.6 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 CCF46809.1 - 1.1e-05 25.3 0.0 2.6e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 twin BRCT domain RTT107_BRCT_5 PF16770.5 CCF46809.1 - 0.00079 19.3 0.0 0.0014 18.4 0.0 1.4 1 0 0 1 1 1 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT_2 PF16589.5 CCF46809.1 - 0.0043 17.4 0.0 0.0081 16.6 0.0 1.4 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT_3 PF18428.1 CCF46809.1 - 0.016 15.3 0.4 0.03 14.4 0.4 1.4 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 CCF46809.1 - 0.054 13.8 0.2 0.098 13.0 0.2 1.4 1 0 0 1 1 1 0 DNA ligase 3 BRCT domain BATS PF06968.13 CCF46810.1 - 1.9e-24 85.6 0.6 5.7e-24 84.1 0.1 2.1 2 1 1 3 3 3 1 Biotin and Thiamin Synthesis associated domain Radical_SAM PF04055.21 CCF46810.1 - 6e-16 59.3 0.0 1.2e-15 58.3 0.0 1.5 2 0 0 2 2 2 1 Radical SAM superfamily Tubulin PF00091.25 CCF46811.1 - 6.1e-52 176.7 0.0 9e-52 176.1 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 CCF46811.1 - 2.2e-45 153.9 0.0 3.4e-45 153.3 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 CCF46811.1 - 6.9e-05 22.6 0.0 0.00013 21.7 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain Enterotoxin_a PF01375.17 CCF46812.1 - 3.2e-25 89.2 0.0 5.1e-25 88.5 0.0 1.3 1 1 0 1 1 1 1 Heat-labile enterotoxin alpha chain Penaeidin PF05927.11 CCF46813.1 - 4.9 8.0 11.2 42 5.0 11.2 1.9 1 1 0 1 1 1 0 Penaeidin Pro_CA PF00484.19 CCF46815.1 - 0.0064 16.8 0.0 0.028 14.7 0.0 1.9 1 1 0 1 1 1 1 Carbonic anhydrase ThiF PF00899.21 CCF46816.1 - 8.7e-57 192.3 0.0 1.3e-56 191.7 0.0 1.3 1 0 0 1 1 1 1 ThiF family Rhodanese PF00581.20 CCF46816.1 - 9.1e-05 22.9 0.1 0.00071 20.1 0.0 2.2 2 0 0 2 2 2 1 Rhodanese-like domain NAD_binding_7 PF13241.6 CCF46816.1 - 0.012 16.0 0.0 0.026 15.0 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding Shikimate_DH PF01488.20 CCF46816.1 - 0.022 14.8 2.7 0.11 12.5 0.0 3.0 3 1 0 4 4 4 0 Shikimate / quinate 5-dehydrogenase UDPG_MGDP_dh_N PF03721.14 CCF46816.1 - 0.056 13.0 0.8 0.1 12.2 0.8 1.6 1 1 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain GARP PF16731.5 CCF46816.1 - 0.52 10.0 5.7 0.74 9.5 5.7 1.2 1 0 0 1 1 1 0 Glutamic acid/alanine-rich protein of Trypanosoma NBP1 PF08537.10 CCF46816.1 - 0.64 9.4 1.8 0.88 8.9 1.8 1.2 1 0 0 1 1 1 0 Fungal Nap binding protein NBP1 MFS_Mycoplasma PF07672.13 CCF46817.1 - 0.0019 17.5 0.4 0.0019 17.5 0.4 2.1 2 0 0 2 2 2 1 Mycoplasma MFS transporter CKAP2_C PF15297.6 CCF46820.1 - 0.25 10.4 0.1 0.32 10.0 0.1 1.1 1 0 0 1 1 1 0 Cytoskeleton-associated protein 2 C-terminus DUF5427 PF10310.9 CCF46821.1 - 1.9e-42 145.8 0.2 2.1e-42 145.7 0.2 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5427) NAD_binding_8 PF13450.6 CCF46823.1 - 4.7e-08 33.2 1.4 5.5e-08 32.9 1.4 1.2 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CCF46823.1 - 4.2e-07 29.9 2.7 4.4e-07 29.8 2.7 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCF46823.1 - 1.8e-06 27.4 1.5 2e-06 27.3 1.5 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCF46823.1 - 2e-05 25.0 1.3 2.3e-05 24.9 1.3 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CCF46823.1 - 2.9e-05 23.3 2.4 3e-05 23.3 2.4 1.0 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 CCF46823.1 - 0.00015 21.2 2.6 0.00017 21.1 2.6 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 CCF46823.1 - 0.00031 19.6 0.7 0.00035 19.4 0.7 1.0 1 0 0 1 1 1 1 HI0933-like protein GIDA PF01134.22 CCF46823.1 - 0.0006 19.0 1.6 0.00064 18.9 1.6 1.0 1 0 0 1 1 1 1 Glucose inhibited division protein A Amino_oxidase PF01593.24 CCF46823.1 - 0.0011 18.3 0.0 0.0013 18.1 0.0 1.0 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_2 PF03446.15 CCF46823.1 - 0.0013 18.9 0.5 0.0014 18.8 0.5 1.1 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Rossmann-like PF10727.9 CCF46823.1 - 0.0013 18.6 0.3 0.0013 18.6 0.3 1.1 1 0 0 1 1 1 1 Rossmann-like domain FAD_binding_3 PF01494.19 CCF46823.1 - 0.0027 17.0 0.7 0.0029 16.9 0.7 1.0 1 0 0 1 1 1 1 FAD binding domain 3HCDH_N PF02737.18 CCF46823.1 - 0.0036 17.2 1.6 0.0038 17.1 1.6 1.0 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.23 CCF46823.1 - 0.0051 16.8 0.3 0.0055 16.7 0.3 1.1 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Pyr_redox_3 PF13738.6 CCF46823.1 - 0.0063 15.8 0.3 0.0063 15.8 0.3 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 CCF46823.1 - 0.01 15.2 0.9 0.01 15.2 0.9 1.0 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Trp_halogenase PF04820.14 CCF46823.1 - 0.046 12.6 1.0 0.046 12.6 1.0 1.0 1 0 0 1 1 1 0 Tryptophan halogenase Thi4 PF01946.17 CCF46823.1 - 0.056 12.7 0.3 0.063 12.5 0.3 1.0 1 0 0 1 1 1 0 Thi4 family F420_oxidored PF03807.17 CCF46823.1 - 0.082 13.5 0.8 0.092 13.3 0.8 1.1 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.19 CCF46823.1 - 0.12 11.7 0.6 0.12 11.7 0.6 1.0 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ApbA PF02558.16 CCF46823.1 - 0.18 11.5 0.8 0.2 11.3 0.8 1.1 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA PAF-AH_p_II PF03403.13 CCF46824.1 - 0.0011 17.5 0.0 0.42 9.1 0.0 2.7 2 1 0 2 2 2 2 Platelet-activating factor acetylhydrolase, isoform II BAAT_C PF08840.11 CCF46824.1 - 0.2 11.5 0.0 0.33 10.8 0.0 1.3 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal PHO4 PF01384.20 CCF46825.1 - 7.8e-112 373.6 7.4 9.1e-112 373.4 7.4 1.0 1 0 0 1 1 1 1 Phosphate transporter family DUF2070 PF09843.9 CCF46825.1 - 0.077 11.3 5.2 0.15 10.3 5.2 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Phage_Coat_B PF05356.11 CCF46825.1 - 7.8 6.5 6.8 0.72 9.8 0.3 2.7 3 0 0 3 3 3 0 Phage Coat protein B Chromo PF00385.24 CCF46827.1 - 0.00033 20.5 0.1 0.00072 19.4 0.1 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Ank_2 PF12796.7 CCF46828.1 - 6e-05 23.6 0.0 0.00092 19.8 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 CCF46828.1 - 0.0016 18.8 0.5 6.9 7.3 0.1 3.6 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 CCF46828.1 - 0.0032 17.8 0.0 54 4.8 0.0 3.8 3 0 0 3 3 3 0 Ankyrin repeat Ank_4 PF13637.6 CCF46828.1 - 0.0034 17.9 0.1 0.12 13.0 0.0 3.0 2 1 1 3 3 3 1 Ankyrin repeats (many copies) AAA_11 PF13086.6 CCF46831.1 - 2.7e-60 204.3 0.3 5.8e-60 203.3 0.3 1.5 1 1 0 1 1 1 1 AAA domain AAA_12 PF13087.6 CCF46831.1 - 2.8e-14 53.2 0.2 1.4e-13 50.9 0.1 1.9 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 CCF46831.1 - 4.8e-12 46.0 0.0 1.8e-10 40.9 0.0 2.8 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CCF46831.1 - 9e-09 35.8 0.0 1.9e-08 34.7 0.0 1.6 1 1 0 1 1 1 1 AAA domain DUF2075 PF09848.9 CCF46831.1 - 1.6e-07 30.9 1.4 4.9e-07 29.3 0.6 2.0 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) ResIII PF04851.15 CCF46831.1 - 5.4e-07 29.8 0.0 6.8e-06 26.2 0.0 2.1 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit UvrD-helicase PF00580.21 CCF46831.1 - 9.6e-06 25.3 0.1 0.00096 18.8 0.0 2.0 1 1 0 2 2 2 1 UvrD/REP helicase N-terminal domain Viral_helicase1 PF01443.18 CCF46831.1 - 1.3e-05 25.1 0.0 0.022 14.5 0.0 2.3 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.6 CCF46831.1 - 3.1e-05 24.2 0.6 0.0026 18.1 0.6 2.4 1 1 0 1 1 1 1 AAA domain Helicase_RecD PF05127.14 CCF46831.1 - 0.00013 21.9 0.0 0.089 12.6 0.0 2.3 2 0 0 2 2 2 2 Helicase AAA_25 PF13481.6 CCF46831.1 - 0.00098 18.7 0.2 0.11 12.1 0.0 2.9 2 1 0 3 3 3 1 AAA domain DEAD PF00270.29 CCF46831.1 - 0.0013 18.5 0.1 0.041 13.6 0.0 2.2 1 1 1 2 2 2 1 DEAD/DEAH box helicase T2SSE PF00437.20 CCF46831.1 - 0.0014 17.7 0.0 0.0044 16.1 0.0 1.7 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_16 PF13191.6 CCF46831.1 - 0.0016 18.9 0.1 0.0029 18.0 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain PhoH PF02562.16 CCF46831.1 - 0.0032 16.9 0.0 0.27 10.7 0.0 2.2 2 0 0 2 2 2 1 PhoH-like protein Flavi_DEAD PF07652.14 CCF46831.1 - 0.0072 16.3 0.0 0.067 13.2 0.0 2.4 3 0 0 3 3 3 1 Flavivirus DEAD domain AAA PF00004.29 CCF46831.1 - 0.0093 16.4 0.3 0.061 13.8 0.0 2.2 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 CCF46831.1 - 0.01 15.6 0.0 0.034 13.9 0.0 1.9 2 0 0 2 2 2 0 IstB-like ATP binding protein SKI PF01202.22 CCF46831.1 - 0.02 15.0 0.1 0.053 13.7 0.1 1.7 2 0 0 2 2 2 0 Shikimate kinase AAA_24 PF13479.6 CCF46831.1 - 0.022 14.5 0.2 0.15 11.8 0.2 2.2 1 1 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.18 CCF46831.1 - 0.042 13.2 0.1 0.85 8.9 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family Zot PF05707.12 CCF46831.1 - 0.065 12.9 0.0 6.3 6.4 0.0 2.3 2 0 0 2 2 2 0 Zonular occludens toxin (Zot) ABC_tran PF00005.27 CCF46831.1 - 0.093 13.3 0.1 0.21 12.1 0.1 1.9 1 1 0 1 1 1 0 ABC transporter AAA_33 PF13671.6 CCF46831.1 - 0.1 12.8 0.0 0.2 11.8 0.0 1.7 1 1 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 CCF46831.1 - 0.11 11.9 0.0 0.2 11.0 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI NTPase_1 PF03266.15 CCF46831.1 - 0.33 10.8 2.3 5.9 6.8 0.0 2.7 3 1 0 3 3 2 0 NTPase NUC202 PF08166.12 CCF46832.1 - 0.091 12.8 0.1 0.15 12.2 0.1 1.3 1 0 0 1 1 1 0 NUC202 domain zf-C2H2_4 PF13894.6 CCF46833.1 - 7.2e-06 26.4 17.5 0.26 12.3 0.3 5.1 4 1 0 4 4 4 3 C2H2-type zinc finger zf-C2H2 PF00096.26 CCF46833.1 - 0.00023 21.4 17.9 0.68 10.5 2.6 4.6 4 1 0 4 4 4 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CCF46833.1 - 0.035 14.5 12.4 1.7 9.2 0.7 4.7 4 1 0 4 4 4 0 Zinc-finger double domain IBR PF01485.21 CCF46833.1 - 0.61 10.3 9.2 26 5.1 9.2 2.9 1 1 0 1 1 1 0 IBR domain, a half RING-finger domain DnaJ_CXXCXGXG PF00684.19 CCF46833.1 - 0.69 10.3 5.2 1.4 9.3 1.8 2.4 1 1 1 2 2 2 0 DnaJ central domain zf-TAZ PF02135.16 CCF46833.1 - 1.1 9.8 7.4 0.39 11.2 2.8 2.4 2 2 0 2 2 2 0 TAZ zinc finger zf-C2H2_jaz PF12171.8 CCF46833.1 - 7.3 7.0 6.3 23 5.4 0.1 3.5 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding CRAL_TRIO PF00650.20 CCF46834.1 - 4.9e-28 97.9 0.0 6.1e-28 97.5 0.0 1.1 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 CCF46834.1 - 0.0016 18.6 0.0 0.0021 18.2 0.0 1.1 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Ribosomal_60s PF00428.19 CCF46834.1 - 0.15 12.7 9.9 0.24 12.0 9.9 1.3 1 0 0 1 1 1 0 60s Acidic ribosomal protein TRAPP PF04051.16 CCF46835.1 - 5e-12 45.8 0.0 6.1e-12 45.5 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component OPT PF03169.15 CCF46837.1 - 3e-25 88.9 25.0 7.9e-25 87.6 25.0 1.6 1 1 0 1 1 1 1 OPT oligopeptide transporter protein ADH_N PF08240.12 CCF46838.1 - 5.9e-22 77.6 2.0 8.2e-22 77.2 2.0 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain MFS_1 PF07690.16 CCF46839.1 - 6.3e-21 74.7 14.2 8.1e-21 74.3 14.2 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Rossmann-like PF10727.9 CCF46839.1 - 0.059 13.2 0.2 0.1 12.5 0.2 1.3 1 0 0 1 1 1 0 Rossmann-like domain DUF3681 PF12442.8 CCF46839.1 - 0.21 12.1 14.3 0.087 13.3 3.7 3.7 2 2 1 3 3 3 0 Protein of unknown function (DUF3681) Pex24p PF06398.11 CCF46840.1 - 1.1e-39 136.5 0.3 1.6e-39 135.9 0.3 1.2 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin DUF3292 PF11696.8 CCF46840.1 - 0.0025 16.3 0.8 0.0038 15.7 0.6 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF3292) Reticulon PF02453.17 CCF46840.1 - 0.0073 16.3 0.6 0.029 14.3 0.6 2.0 1 1 0 1 1 1 1 Reticulon DUF639 PF04842.12 CCF46840.1 - 0.22 10.9 0.1 0.22 10.9 0.1 1.5 2 0 0 2 2 2 0 Plant protein of unknown function (DUF639) AAA_2 PF07724.14 CCF46841.1 - 2.6e-44 151.3 0.0 3.8e-44 150.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) ClpB_D2-small PF10431.9 CCF46841.1 - 3.4e-11 43.1 2.1 1.8e-07 31.1 0.1 2.7 1 1 1 2 2 2 2 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.14 CCF46841.1 - 1.2e-09 38.3 0.0 2.1e-09 37.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA PF00004.29 CCF46841.1 - 7.2e-07 29.7 0.0 1.5e-06 28.6 0.0 1.6 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 CCF46841.1 - 6.6e-05 22.7 0.0 0.0001 22.0 0.0 1.3 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_16 PF13191.6 CCF46841.1 - 0.0029 18.0 0.4 0.026 14.9 0.1 2.1 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 CCF46841.1 - 0.0066 16.7 0.1 0.034 14.4 0.1 2.1 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CCF46841.1 - 0.041 14.4 0.1 0.071 13.7 0.1 1.5 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CCF46841.1 - 0.043 14.3 0.0 0.064 13.8 0.0 1.3 1 0 0 1 1 1 0 ABC transporter RNA_helicase PF00910.22 CCF46841.1 - 0.059 13.8 0.1 0.27 11.6 0.0 2.2 2 1 0 2 2 2 0 RNA helicase Mg_chelatase PF01078.21 CCF46841.1 - 0.069 12.5 0.1 0.81 9.0 0.0 2.2 1 1 1 2 2 2 0 Magnesium chelatase, subunit ChlI NACHT PF05729.12 CCF46841.1 - 0.11 12.4 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 NACHT domain SRP54 PF00448.22 CCF46841.1 - 0.11 12.1 0.0 0.18 11.4 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_7 PF12775.7 CCF46841.1 - 0.12 11.9 0.0 0.22 11.0 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_14 PF13173.6 CCF46841.1 - 0.14 12.2 0.0 0.27 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 CCF46841.1 - 0.14 11.9 0.0 0.25 11.1 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_24 PF13479.6 CCF46841.1 - 0.15 11.8 0.0 0.24 11.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain Arf PF00025.21 CCF46842.1 - 2.6e-80 268.0 0.3 3e-80 267.8 0.3 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 CCF46842.1 - 1.7e-14 54.1 0.0 2.3e-14 53.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 CCF46842.1 - 2e-14 53.4 0.0 2.5e-14 53.1 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 CCF46842.1 - 2.6e-13 49.9 1.5 2e-09 37.1 0.5 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 CCF46842.1 - 3.4e-13 49.5 0.0 3.8e-13 49.4 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 CCF46842.1 - 1.2e-10 41.1 0.0 1.6e-10 40.7 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 CCF46842.1 - 2.9e-06 27.3 0.0 4.5e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 CCF46842.1 - 0.0095 15.3 1.0 0.028 13.7 1.0 1.8 1 1 0 1 1 1 1 6-phosphofructo-2-kinase EMP24_GP25L PF01105.24 CCF46843.1 - 3.8e-45 154.1 0.0 4.4e-45 153.9 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Dioxygenase_C PF00775.21 CCF46843.1 - 0.085 12.3 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 Dioxygenase DUF3405 PF11885.8 CCF46844.1 - 9.4e-232 770.2 4.6 1.1e-231 769.9 4.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3405) DUF3659 PF12396.8 CCF46845.1 - 3.9e-17 61.9 4.2 3.9e-17 61.9 4.2 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF3659) DUF1917 PF08939.10 CCF46845.1 - 0.0014 18.6 1.3 0.0019 18.1 1.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1917) DUF3849 PF12960.7 CCF46845.1 - 0.11 12.6 0.0 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3849) EspB PF05802.11 CCF46845.1 - 0.12 12.4 1.8 1.3 9.0 1.8 2.3 1 1 0 1 1 1 0 Enterobacterial EspB protein CorA PF01544.18 CCF46845.1 - 0.36 10.1 1.2 0.48 9.7 1.2 1.1 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Spore_III_AB PF09548.10 CCF46845.1 - 0.49 10.5 2.9 2.9 8.0 0.3 2.3 1 1 1 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) RRM_1 PF00076.22 CCF46847.1 - 2.4e-08 33.7 0.1 4.3e-08 32.9 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 CCF46847.1 - 9.2e-05 22.4 0.0 0.00017 21.5 0.0 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 CCF46847.1 - 0.005 16.7 0.1 0.0088 15.9 0.1 1.3 1 0 0 1 1 1 1 Occluded RNA-recognition motif RRM_3 PF08777.11 CCF46847.1 - 0.088 12.9 0.1 0.16 12.0 0.1 1.4 1 0 0 1 1 1 0 RNA binding motif MFS_1 PF07690.16 CCF46848.1 - 7.7e-35 120.4 21.3 1e-34 120.0 21.3 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Fungal_trans PF04082.18 CCF46849.1 - 1.2e-20 73.6 0.1 5.6e-20 71.5 0.1 1.9 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF46849.1 - 1.7e-07 31.3 12.1 2.8e-07 30.5 12.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ad_cyc_g-alpha PF08509.11 CCF46849.1 - 0.14 11.9 0.2 26 4.6 0.1 2.6 2 0 0 2 2 2 0 Adenylate cyclase G-alpha binding domain Hydantoinase_B PF02538.14 CCF46851.1 - 7.1e-212 704.4 1.1 9.2e-212 704.0 1.1 1.1 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.18 CCF46851.1 - 1.2e-102 343.1 0.5 2.7e-102 341.9 0.1 1.8 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 CCF46851.1 - 1.1e-58 197.9 3.0 6.7e-58 195.3 0.1 2.5 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase N-terminal region AmiS_UreI PF02293.15 CCF46852.1 - 0.041 13.9 5.7 0.16 12.0 0.4 2.5 2 0 0 2 2 2 0 AmiS/UreI family transporter Arginase PF00491.21 CCF46854.1 - 2.7e-90 302.7 0.0 3.4e-90 302.3 0.0 1.0 1 0 0 1 1 1 1 Arginase family UPF0489 PF12640.7 CCF46854.1 - 0.081 13.2 0.0 0.13 12.5 0.0 1.3 1 0 0 1 1 1 0 UPF0489 domain DUF1589 PF07628.11 CCF46854.1 - 0.14 12.3 0.0 0.77 9.9 0.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1589) SpoU_methylase PF00588.19 CCF46857.1 - 4e-27 95.1 0.0 6.3e-27 94.5 0.0 1.3 1 0 0 1 1 1 1 SpoU rRNA Methylase family SpoU_sub_bind PF08032.12 CCF46857.1 - 9e-11 41.9 0.0 1.7e-10 41.0 0.0 1.5 1 0 0 1 1 1 1 RNA 2'-O ribose methyltransferase substrate binding zf-PHD-like PF15446.6 CCF46859.1 - 1.4e-70 236.3 10.8 3.7e-70 234.9 10.8 1.8 1 0 0 1 1 1 1 PHD/FYVE-zinc-finger like domain SNF2_N PF00176.23 CCF46859.1 - 4.6e-50 170.3 0.4 3.5e-49 167.4 0.4 2.0 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CCF46859.1 - 2.6e-19 69.6 0.0 1e-18 67.7 0.0 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 CCF46859.1 - 6.5e-10 38.7 4.0 2.3e-09 36.9 4.0 1.9 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.15 CCF46859.1 - 3.2e-08 33.8 0.0 1.1e-07 32.0 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 CCF46859.1 - 0.00011 22.0 0.0 0.0002 21.2 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase PHD PF00628.29 CCF46859.1 - 0.00012 21.9 4.1 0.00012 21.9 4.1 3.2 2 1 1 3 3 3 1 PHD-finger Chromo PF00385.24 CCF46859.1 - 0.00014 21.7 0.8 0.00014 21.7 0.8 3.5 4 0 0 4 4 4 1 Chromo (CHRromatin Organisation MOdifier) domain PHD_2 PF13831.6 CCF46859.1 - 0.022 14.3 0.3 0.022 14.3 0.3 2.6 3 0 0 3 3 3 0 PHD-finger Zf_RING PF16744.5 CCF46859.1 - 0.028 14.5 9.1 0.2 11.8 0.6 2.7 2 1 0 2 2 2 0 KIAA1045 RING finger Amidohydro_1 PF01979.20 CCF46861.1 - 7.9e-08 32.0 0.1 1.2e-07 31.4 0.1 1.3 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_2 PF04909.14 CCF46861.1 - 0.00093 19.1 0.0 0.0015 18.4 0.0 1.3 1 0 0 1 1 1 1 Amidohydrolase TatD_DNase PF01026.21 CCF46861.1 - 0.018 14.4 0.2 0.05 13.0 0.2 1.7 1 1 0 1 1 1 0 TatD related DNase DUF166 PF02593.14 CCF46861.1 - 0.026 14.1 0.0 0.042 13.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function LysR_substrate PF03466.20 CCF46861.1 - 0.034 13.5 0.1 0.32 10.3 0.0 2.2 2 0 0 2 2 2 0 LysR substrate binding domain CoA_binding_2 PF13380.6 CCF46861.1 - 0.054 14.0 0.0 0.22 12.0 0.0 2.0 2 0 0 2 2 2 0 CoA binding domain YL1_C PF08265.11 CCF46862.1 - 0.0085 15.8 0.9 0.024 14.4 0.1 2.2 2 0 0 2 2 2 1 YL1 nuclear protein C-terminal domain DUF1515 PF07439.11 CCF46862.1 - 0.19 11.8 0.3 16 5.5 0.0 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1515) ADH_N PF08240.12 CCF46863.1 - 0.036 14.0 0.0 0.049 13.5 0.0 1.2 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain ADH_N_2 PF16884.5 CCF46863.1 - 0.092 12.7 0.0 0.13 12.1 0.0 1.4 1 1 0 1 1 1 0 N-terminal domain of oxidoreductase HMG_CoA_synt_N PF01154.17 CCF46865.1 - 6.6e-96 319.2 0.5 9.5e-96 318.6 0.5 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal HMG_CoA_synt_C PF08540.10 CCF46865.1 - 4.8e-74 249.5 0.7 7.1e-74 248.9 0.7 1.3 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal Aminotran_5 PF00266.19 CCF46866.1 - 6.7e-74 249.1 0.0 8.2e-74 248.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 CCF46866.1 - 5.5e-06 25.9 0.1 8.8e-06 25.2 0.1 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 CCF46866.1 - 3.2e-05 23.4 0.0 5.2e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Pyridoxal_deC PF00282.19 CCF46866.1 - 0.002 16.9 0.0 0.0034 16.2 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Cys_Met_Meta_PP PF01053.20 CCF46866.1 - 0.01 14.4 0.0 0.014 14.0 0.0 1.1 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme B12-binding PF02310.19 CCF46866.1 - 0.024 14.7 0.0 0.15 12.1 0.0 2.2 2 1 0 2 2 2 0 B12 binding domain DUF3942 PF13078.6 CCF46866.1 - 0.047 14.0 0.1 0.1 12.9 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3942) RbsD_FucU PF05025.13 CCF46867.1 - 2.6e-35 121.8 0.0 3e-35 121.6 0.0 1.0 1 0 0 1 1 1 1 RbsD / FucU transport protein family DASH_Spc34 PF08657.10 CCF46869.1 - 1.3e-40 139.8 0.0 3.7e-24 85.9 0.1 2.0 1 1 1 2 2 2 2 DASH complex subunit Spc34 CAP_N PF01213.19 CCF46869.1 - 0.029 13.9 1.1 0.038 13.5 1.1 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal ABC2_membrane PF01061.24 CCF46870.1 - 4.5e-42 143.9 16.5 6.2e-42 143.4 16.5 1.1 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 CCF46870.1 - 4.5e-18 66.1 0.0 7.8e-15 55.6 0.0 2.3 2 0 0 2 2 2 2 ABC transporter ABC_trans_N PF14510.6 CCF46870.1 - 6e-14 52.4 0.0 1.5e-13 51.1 0.0 1.7 1 0 0 1 1 1 1 ABC-transporter N-terminal ABC2_membrane_3 PF12698.7 CCF46870.1 - 0.46 9.5 15.9 0.11 11.6 12.1 1.6 1 1 0 1 1 1 0 ABC-2 family transporter protein CDP-OH_P_transf PF01066.21 CCF46871.1 - 2.2e-13 50.8 0.4 2.2e-13 50.8 0.4 3.1 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase DUF5446 PF17522.2 CCF46872.1 - 0.13 12.4 0.1 0.26 11.5 0.0 1.5 2 0 0 2 2 2 0 Family of unknown function (DUF5446) Aldedh PF00171.22 CCF46873.1 - 1.1e-35 123.1 0.1 1.2e-35 122.9 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family ABC2_membrane PF01061.24 CCF46874.1 - 6.7e-42 143.3 21.9 6.7e-42 143.3 21.9 1.5 2 0 0 2 2 2 1 ABC-2 type transporter ABC2_membrane_3 PF12698.7 CCF46874.1 - 2.2e-07 30.3 18.4 3.4e-07 29.7 18.4 1.4 1 1 0 1 1 1 1 ABC-2 family transporter protein PDR_CDR PF06422.12 CCF46874.1 - 0.0013 18.6 0.3 0.0013 18.6 0.3 3.0 3 1 0 3 3 3 1 CDR ABC transporter Nup96 PF12110.8 CCF46875.1 - 1.7e-82 276.9 1.0 2.2e-82 276.5 1.0 1.1 1 0 0 1 1 1 1 Nuclear protein 96 Sec39 PF08314.11 CCF46877.1 - 1.5e-251 837.1 0.0 2.5e-175 585.0 0.0 2.0 1 1 1 2 2 2 2 Secretory pathway protein Sec39 Ndufs5 PF10200.9 CCF46878.1 - 3e-05 24.2 0.0 3.6e-05 23.9 0.0 1.1 1 0 0 1 1 1 1 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa DUF3128 PF11326.8 CCF46878.1 - 0.011 16.0 0.9 0.031 14.6 0.9 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3128) COX6B PF02297.17 CCF46878.1 - 0.071 13.4 0.3 0.1 12.8 0.3 1.3 1 0 0 1 1 1 0 Cytochrome oxidase c subunit VIb MazE_antitoxin PF04014.18 CCF46880.1 - 0.0031 17.4 0.1 0.96 9.5 0.0 2.4 2 0 0 2 2 2 2 Antidote-toxin recognition MazE, bacterial antitoxin NAD_binding_1 PF00175.21 CCF46880.1 - 0.016 15.9 0.0 0.029 15.0 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 CCF46880.1 - 0.04 14.0 0.0 0.061 13.4 0.0 1.3 1 0 0 1 1 1 0 Ferric reductase NAD binding domain FeoA PF04023.14 CCF46880.1 - 0.14 12.5 0.0 0.28 11.5 0.0 1.5 1 0 0 1 1 1 0 FeoA domain Intein_splicing PF14890.6 CCF46880.1 - 0.17 11.8 0.0 0.25 11.3 0.0 1.2 1 0 0 1 1 1 0 Intein splicing domain Adaptin_N PF01602.20 CCF46881.1 - 2.6e-30 105.5 0.7 3e-30 105.3 0.7 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.20 CCF46881.1 - 1.5e-19 70.3 0.1 6e-19 68.4 0.0 2.1 2 0 0 2 2 2 1 Adaptin C-terminal domain Condensation PF00668.20 CCF46882.1 - 0.022 13.4 0.0 0.045 12.4 0.0 1.7 1 1 0 1 1 1 0 Condensation domain DnaB_bind PF10410.9 CCF46884.1 - 0.13 12.4 0.0 0.18 12.0 0.0 1.1 1 0 0 1 1 1 0 DnaB-helicase binding domain of primase DS PF01916.17 CCF46885.1 - 1.2e-48 165.8 0.1 1.3e-48 165.7 0.1 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase MARVEL PF01284.23 CCF46886.1 - 1.2e-08 35.1 7.9 1.4e-08 34.8 7.9 1.0 1 0 0 1 1 1 1 Membrane-associating domain SDH_C PF18317.1 CCF46886.1 - 0.084 12.7 0.8 0.084 12.7 0.8 2.0 2 0 0 2 2 2 0 Shikimate 5'-dehydrogenase C-terminal domain Steroid_dh PF02544.16 CCF46887.1 - 2.1e-18 66.8 1.5 9.2e-13 48.4 1.5 2.2 2 0 0 2 2 2 2 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.12 CCF46887.1 - 0.026 14.0 4.8 0.078 12.5 4.8 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1295) Aldedh PF00171.22 CCF46888.1 - 1.1e-153 512.0 0.1 1.3e-153 511.9 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Peptidase_S48 PF03574.15 CCF46889.1 - 0.061 13.5 0.0 0.073 13.3 0.0 1.1 1 0 0 1 1 1 0 Peptidase family S48 DUF3987 PF13148.6 CCF46889.1 - 1.5 7.8 9.5 1.6 7.6 9.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) RRM_1 PF00076.22 CCF46890.1 - 4.7e-17 61.6 0.1 6.3e-17 61.2 0.1 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CCF46890.1 - 0.0026 17.6 0.0 0.0044 16.9 0.0 1.4 1 1 0 1 1 1 1 Occluded RNA-recognition motif zf-MIZ PF02891.20 CCF46891.1 - 1.3e-08 34.4 3.7 1.1e-06 28.3 0.3 2.8 2 0 0 2 2 2 2 MIZ/SP-RING zinc finger DDHD PF02862.17 CCF46891.1 - 0.47 10.6 20.7 1.6 8.9 20.7 1.9 1 0 0 1 1 1 0 DDHD domain Mem_trans PF03547.18 CCF46891.1 - 3.2 6.0 3.9 4.7 5.5 3.9 1.2 1 0 0 1 1 1 0 Membrane transport protein GREB1 PF15782.5 CCF46891.1 - 4.6 4.2 32.4 8.4 3.4 32.4 1.3 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer CDC45 PF02724.14 CCF46891.1 - 5 5.3 28.9 0.11 10.8 21.6 1.7 2 0 0 2 2 2 0 CDC45-like protein Tim54 PF11711.8 CCF46891.1 - 5.8 5.6 23.6 15 4.3 23.6 1.6 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Cellulose_synt PF03552.14 CCF46891.1 - 6.7 5.1 9.5 10 4.5 9.5 1.2 1 0 0 1 1 1 0 Cellulose synthase Presenilin PF01080.17 CCF46891.1 - 7.3 5.2 36.5 15 4.2 36.5 1.4 1 0 0 1 1 1 0 Presenilin Arrestin_N PF00339.29 CCF46893.1 - 1.5e-16 60.8 0.0 2.7e-11 43.7 0.0 3.0 3 0 0 3 3 3 2 Arrestin (or S-antigen), N-terminal domain SET PF00856.28 CCF46894.1 - 1.4e-09 38.6 0.0 1.7e-08 35.1 0.0 2.3 1 1 0 1 1 1 1 SET domain MFS_1 PF07690.16 CCF46896.1 - 3.4e-11 42.7 21.0 4.5e-11 42.3 21.0 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF46896.1 - 4.4e-07 29.1 5.1 5.5e-07 28.8 5.1 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter Borrelia_P13 PF05628.12 CCF46896.1 - 0.73 9.8 2.9 1.4 8.9 2.9 1.4 1 0 0 1 1 1 0 Borrelia membrane protein P13 HET PF06985.11 CCF46898.1 - 4.8e-05 23.8 0.0 0.058 13.8 0.0 3.0 2 1 1 3 3 3 2 Heterokaryon incompatibility protein (HET) DUF1485 PF07364.12 CCF46898.1 - 0.11 11.7 0.1 0.17 11.2 0.1 1.2 1 0 0 1 1 1 0 Metallopeptidase family M81 SUIM_assoc PF16619.5 CCF46899.1 - 0.011 15.8 11.3 0.011 15.8 11.3 2.3 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 TFIIA PF03153.13 CCF46899.1 - 0.72 9.8 11.9 0.93 9.4 11.9 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Roughex PF06020.11 CCF46899.1 - 1.3 8.0 9.4 0.35 9.9 6.6 1.5 1 1 1 2 2 2 0 Drosophila roughex protein Miga PF10265.9 CCF46899.1 - 8.7 5.2 6.9 0.76 8.7 1.7 1.7 1 1 1 2 2 2 0 Mitoguardin AA_kinase PF00696.28 CCF46901.1 - 5.7e-26 91.6 0.2 1.3e-25 90.4 0.0 1.6 2 0 0 2 2 2 1 Amino acid kinase family ACT_7 PF13840.6 CCF46901.1 - 5.3e-14 51.7 4.0 1.5e-09 37.5 0.2 2.4 2 0 0 2 2 2 2 ACT domain ACT PF01842.25 CCF46901.1 - 1e-13 50.8 1.3 8e-08 31.9 0.1 2.5 2 0 0 2 2 2 2 ACT domain Peptidase_C14 PF00656.22 CCF46902.1 - 1.6e-05 25.0 0.0 3.1e-05 24.1 0.0 1.6 1 1 0 1 1 1 1 Caspase domain NAD_binding_10 PF13460.6 CCF46904.1 - 1.5e-06 28.3 0.0 2.5e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CCF46904.1 - 1.8e-05 24.4 0.0 0.0072 15.8 0.0 2.3 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CCF46904.1 - 0.0021 17.1 0.0 0.0067 15.5 0.0 1.8 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Semialdhyde_dh PF01118.24 CCF46904.1 - 0.0031 17.9 0.0 0.01 16.3 0.0 1.9 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain NAD_binding_4 PF07993.12 CCF46904.1 - 0.033 13.4 0.0 0.11 11.7 0.0 1.8 1 1 0 1 1 1 0 Male sterility protein NmrA PF05368.13 CCF46904.1 - 0.039 13.5 0.0 0.061 12.9 0.0 1.3 1 0 0 1 1 1 0 NmrA-like family Cep57_CLD_2 PF14197.6 CCF46905.1 - 1.6e-30 105.0 60.6 4e-17 62.0 4.4 5.9 5 1 0 5 5 5 3 Centrosome localisation domain of PPC89 Cep57_MT_bd PF06657.13 CCF46905.1 - 2.2e-28 98.5 0.4 2.2e-28 98.5 0.4 6.0 5 1 1 6 6 6 1 Centrosome microtubule-binding domain of Cep57 ATG16 PF08614.11 CCF46905.1 - 0.00031 21.0 32.8 0.00031 21.0 32.8 5.7 4 2 1 5 5 5 1 Autophagy protein 16 (ATG16) KASH_CCD PF14662.6 CCF46905.1 - 0.013 15.3 0.6 0.013 15.3 0.6 5.9 2 1 2 5 5 5 0 Coiled-coil region of CCDC155 or KASH HALZ PF02183.18 CCF46905.1 - 0.023 14.9 3.3 0.023 14.9 3.3 7.6 5 2 3 8 8 8 0 Homeobox associated leucine zipper DUF730 PF05325.11 CCF46905.1 - 0.041 13.9 0.5 0.041 13.9 0.5 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF730) ZapB PF06005.12 CCF46905.1 - 0.97 9.9 59.8 0.72 10.3 4.6 7.5 3 2 3 6 6 6 0 Cell division protein ZapB FUSC PF04632.12 CCF46905.1 - 8.4 4.8 13.1 2.8 6.4 8.7 2.2 2 1 0 2 2 2 0 Fusaric acid resistance protein family ABC2_membrane PF01061.24 CCF46906.1 - 3.8e-34 117.9 13.1 5.1e-34 117.5 13.1 1.2 1 0 0 1 1 1 1 ABC-2 type transporter ABC2_membrane_3 PF12698.7 CCF46906.1 - 8.9e-05 21.8 9.1 0.00011 21.4 7.6 1.7 1 1 1 2 2 2 1 ABC-2 family transporter protein PDR_CDR PF06422.12 CCF46906.1 - 0.046 13.6 0.1 0.046 13.6 0.1 2.3 3 0 0 3 3 3 0 CDR ABC transporter AMPK1_CBM PF16561.5 CCF46907.1 - 8.9e-12 45.1 0.1 1.2e-11 44.7 0.1 1.1 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase CBM_48 PF02922.18 CCF46907.1 - 0.0045 17.3 0.1 0.0053 17.1 0.1 1.2 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) CBM53 PF16760.5 CCF46907.1 - 0.0067 17.0 0.3 0.012 16.2 0.2 1.5 1 1 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) SseC PF04888.12 CCF46908.1 - 0.023 14.3 9.2 0.033 13.8 9.2 1.2 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family DUF3450 PF11932.8 CCF46908.1 - 0.52 9.6 8.5 0.076 12.3 4.3 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Abhydrolase_6 PF12697.7 CCF46909.1 - 3.2e-19 70.4 0.6 3.2e-19 70.4 0.6 1.6 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CCF46909.1 - 2.7e-16 60.0 0.0 5.1e-16 59.1 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CCF46909.1 - 6.1e-14 51.9 0.0 1.9e-13 50.2 0.0 1.8 1 1 0 1 1 1 1 Serine aminopeptidase, S33 PGAP1 PF07819.13 CCF46909.1 - 1.4e-06 28.2 0.0 4.4e-05 23.3 0.0 2.1 2 0 0 2 2 2 1 PGAP1-like protein Thioesterase PF00975.20 CCF46909.1 - 5.6e-06 26.6 0.0 1e-05 25.8 0.0 1.4 1 0 0 1 1 1 1 Thioesterase domain DUF3089 PF11288.8 CCF46909.1 - 0.00061 19.4 0.0 0.0012 18.5 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3089) Thiolase_C PF02803.18 CCF46909.1 - 0.0024 17.5 0.0 4.3 7.0 0.0 2.8 3 0 0 3 3 3 2 Thiolase, C-terminal domain Abhydrolase_2 PF02230.16 CCF46909.1 - 0.0037 17.1 0.0 0.31 10.8 0.0 2.6 3 0 0 3 3 3 1 Phospholipase/Carboxylesterase DUF900 PF05990.12 CCF46909.1 - 0.0077 15.8 0.0 0.013 15.1 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) LIDHydrolase PF10230.9 CCF46909.1 - 0.013 15.1 0.0 0.022 14.3 0.0 1.3 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase VirJ PF06057.11 CCF46909.1 - 0.021 14.7 0.0 0.036 14.0 0.0 1.2 1 0 0 1 1 1 0 Bacterial virulence protein (VirJ) DUF676 PF05057.14 CCF46909.1 - 0.057 12.9 0.0 0.09 12.3 0.0 1.3 1 0 0 1 1 1 0 Putative serine esterase (DUF676) LCAT PF02450.15 CCF46909.1 - 0.12 11.5 0.0 0.21 10.7 0.0 1.3 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase Lipase_3 PF01764.25 CCF46909.1 - 0.13 12.2 0.1 0.34 10.8 0.0 1.6 1 1 1 2 2 2 0 Lipase (class 3) DUF498 PF04430.14 CCF46910.1 - 2.2e-29 101.7 0.0 2.8e-29 101.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF498/DUF598) Ribosomal_L34e PF01199.18 CCF46911.1 - 1.6e-43 146.9 1.9 2.3e-43 146.4 1.9 1.2 1 0 0 1 1 1 1 Ribosomal protein L34e Vps36-NZF-N PF16988.5 CCF46911.1 - 0.071 12.5 1.0 0.1 12.0 0.0 1.8 2 0 0 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain FhuF_C PF11575.8 CCF46911.1 - 0.46 10.5 5.4 1.7 8.7 0.3 2.8 3 0 0 3 3 3 0 FhuF 2Fe-2S C-terminal domain FAR1 PF03101.15 CCF46913.1 - 5.7e-06 27.0 0.2 9.8e-06 26.2 0.2 1.3 1 0 0 1 1 1 1 FAR1 DNA-binding domain Tektin PF03148.14 CCF46913.1 - 0.00062 18.6 0.1 0.00085 18.2 0.1 1.1 1 0 0 1 1 1 1 Tektin family Sugarporin_N PF11471.8 CCF46913.1 - 0.0083 16.1 0.3 0.22 11.5 0.1 2.2 1 1 1 2 2 2 2 Maltoporin periplasmic N-terminal extension AFT PF08731.11 CCF46913.1 - 0.015 15.7 0.1 0.022 15.2 0.1 1.3 1 0 0 1 1 1 0 Transcription factor AFT CLZ PF16526.5 CCF46913.1 - 0.026 14.9 0.6 0.15 12.4 0.6 2.1 1 1 1 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DASH_Dad1 PF08649.10 CCF46913.1 - 0.044 14.0 0.1 0.14 12.4 0.1 1.8 2 0 0 2 2 2 0 DASH complex subunit Dad1 XhlA PF10779.9 CCF46913.1 - 0.05 13.8 0.0 0.16 12.2 0.0 1.8 1 1 1 2 2 2 0 Haemolysin XhlA Vac_Fusion PF02346.16 CCF46913.1 - 0.076 12.6 0.2 0.31 10.7 0.3 2.0 1 1 1 2 2 2 0 Chordopoxvirus multifunctional envelope protein A27 Hemagglutinin PF00509.18 CCF46913.1 - 0.094 11.1 0.0 0.12 10.7 0.0 1.1 1 0 0 1 1 1 0 Haemagglutinin Tropomyosin_1 PF12718.7 CCF46913.1 - 0.097 12.8 0.1 0.28 11.3 0.1 1.6 1 1 0 1 1 1 0 Tropomyosin like HSBP1 PF06825.12 CCF46913.1 - 0.13 12.1 2.9 3.2 7.7 0.4 2.7 2 1 0 2 2 2 0 Heat shock factor binding protein 1 Matrilin_ccoil PF10393.9 CCF46913.1 - 0.38 10.7 1.1 0.9 9.5 0.2 2.1 2 1 0 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin DUF1604 PF07713.13 CCF46915.1 - 0.002 17.9 2.4 0.0039 17.0 2.4 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1604) Astro_capsid_p PF12226.8 CCF46915.1 - 0.13 11.4 1.1 0.14 11.2 1.1 1.1 1 0 0 1 1 1 0 Turkey astrovirus capsid protein HTH_psq PF05225.16 CCF46917.1 - 3.5e-11 42.7 0.0 7.9e-11 41.5 0.0 1.6 2 0 0 2 2 2 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.16 CCF46917.1 - 2.8e-09 36.9 0.0 5.1e-09 36.0 0.0 1.4 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_23 PF13384.6 CCF46917.1 - 0.002 17.9 0.1 0.02 14.7 0.0 2.2 2 0 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.6 CCF46917.1 - 0.016 15.3 0.1 0.15 12.2 0.0 2.4 3 0 0 3 3 3 0 Helix-turn-helix domain DUF2244 PF10003.9 CCF46920.1 - 0.1 12.2 5.2 0.11 12.1 5.2 1.1 1 0 0 1 1 1 0 Integral membrane protein (DUF2244) Tropomyosin_1 PF12718.7 CCF46921.1 - 0.11 12.6 3.5 0.21 11.7 3.5 1.4 1 0 0 1 1 1 0 Tropomyosin like LYTB PF02401.18 CCF46921.1 - 0.15 11.3 0.0 0.45 9.7 0.0 1.7 1 1 1 2 2 2 0 LytB protein Sec16_C PF12931.7 CCF46922.1 - 8e-11 42.1 0.5 4.6e-09 36.4 0.5 2.2 1 1 0 1 1 1 1 Sec23-binding domain of Sec16 WD40 PF00400.32 CCF46922.1 - 6.7e-07 29.9 5.2 0.0074 17.1 0.0 6.0 7 0 0 7 7 7 1 WD domain, G-beta repeat Sec16 PF12932.7 CCF46922.1 - 0.014 15.9 1.8 0.051 14.2 1.2 2.3 2 1 0 2 2 2 0 Vesicle coat trafficking protein Sec16 mid-region PALB2_WD40 PF16756.5 CCF46922.1 - 0.049 12.5 0.0 0.26 10.2 0.0 1.9 1 1 1 2 2 2 0 Partner and localizer of BRCA2 WD40 domain RRM_1 PF00076.22 CCF46923.1 - 4.6e-18 64.8 0.0 6.2e-18 64.4 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CCF46923.1 - 2.4e-05 24.4 0.0 3.2e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif RRM_5 PF13893.6 CCF46923.1 - 0.034 13.8 0.0 0.053 13.1 0.0 1.3 1 1 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 CCF46923.1 - 0.072 13.1 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 CCF46923.1 - 0.11 12.6 0.2 0.33 11.0 0.2 2.0 1 1 0 1 1 1 0 RNA binding motif Limkain-b1 PF11608.8 CCF46923.1 - 0.14 12.3 0.0 0.25 11.5 0.0 1.4 1 0 0 1 1 1 0 Limkain b1 RRM_occluded PF16842.5 CCF46923.1 - 0.15 11.9 0.0 0.35 10.8 0.0 1.6 1 1 0 1 1 1 0 Occluded RNA-recognition motif B12D PF06522.11 CCF46924.1 - 1.6e-05 24.6 0.0 2.1e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 NADH-ubiquinone reductase complex 1 MLRQ subunit COX6B PF02297.17 CCF46925.1 - 9.4e-19 67.4 4.2 1.1e-18 67.2 4.2 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb CX9C PF16860.5 CCF46925.1 - 0.017 15.1 2.4 0.026 14.5 2.4 1.2 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, APOBEC_C PF05240.14 CCF46925.1 - 0.092 12.7 2.0 0.095 12.7 1.4 1.6 1 1 0 1 1 1 0 APOBEC-like C-terminal domain ketoacyl-synt PF00109.26 CCF46925.1 - 0.14 11.7 0.0 0.14 11.7 0.0 1.1 1 0 0 1 1 1 0 Beta-ketoacyl synthase, N-terminal domain Sde2_N_Ubi PF13019.6 CCF46926.1 - 4.5e-70 234.7 1.1 6.5e-70 234.2 1.1 1.2 1 0 0 1 1 1 1 Silencing defective 2 N-terminal ubiquitin domain S10_plectin PF03501.15 CCF46927.1 - 2.9e-42 142.7 0.1 3.9e-42 142.2 0.1 1.1 1 0 0 1 1 1 1 Plectin/S10 domain DUF3328 PF11807.8 CCF46928.1 - 0.0021 17.9 0.3 0.0036 17.1 0.3 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF3328) DUF1096 PF06493.11 CCF46928.1 - 0.34 11.4 2.4 0.76 10.3 2.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1096) TMEM208_SND2 PF05620.11 CCF46929.1 - 0.03 14.1 0.8 0.032 14.0 0.8 1.0 1 0 0 1 1 1 0 SRP-independent targeting protein 2/TMEM208 Acetyltransf_1 PF00583.25 CCF46930.1 - 1.3e-05 25.4 0.0 2.1e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 CCF46930.1 - 0.00074 19.6 0.0 0.0015 18.6 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CCF46930.1 - 0.0013 19.1 0.0 0.0026 18.1 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain PLA2G12 PF06951.11 CCF46930.1 - 0.12 12.3 0.0 0.17 11.8 0.0 1.2 1 0 0 1 1 1 0 Group XII secretory phospholipase A2 precursor (PLA2G12) FR47 PF08445.10 CCF46930.1 - 0.12 12.4 0.0 0.23 11.5 0.0 1.5 1 0 0 1 1 1 0 FR47-like protein Acetyltransf_10 PF13673.7 CCF46930.1 - 0.15 12.0 0.0 0.24 11.4 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Hemerythrin PF01814.23 CCF46932.1 - 4.8e-06 27.2 0.9 7.6e-06 26.6 0.6 1.5 1 1 0 1 1 1 1 Hemerythrin HHE cation binding domain DUF2383 PF09537.10 CCF46932.1 - 0.018 15.4 0.0 0.029 14.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2383) MFS_1 PF07690.16 CCF46933.1 - 7.2e-08 31.7 4.3 8.4e-08 31.5 4.3 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily OATP PF03137.20 CCF46933.1 - 0.001 17.5 0.6 0.001 17.4 0.6 1.0 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1_like PF12832.7 CCF46933.1 - 0.0036 16.2 0.3 0.0041 16.0 0.3 1.1 1 0 0 1 1 1 1 MFS_1 like family UQ_con PF00179.26 CCF46934.1 - 6.8e-34 116.5 0.0 9.3e-34 116.1 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Thioredoxin PF00085.20 CCF46935.1 - 1.2e-06 28.4 0.0 1.8e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Redoxin PF08534.10 CCF46935.1 - 0.0053 16.5 0.0 0.0056 16.4 0.0 1.2 1 0 0 1 1 1 1 Redoxin DUF953 PF06110.11 CCF46935.1 - 0.048 13.3 0.3 0.36 10.5 0.3 2.0 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF953) Thioredoxin_9 PF14595.6 CCF46935.1 - 0.062 13.1 0.0 0.54 10.0 0.0 1.9 2 0 0 2 2 2 0 Thioredoxin Thioredoxin_2 PF13098.6 CCF46935.1 - 0.16 12.4 0.0 2 8.9 0.0 2.2 1 1 0 1 1 1 0 Thioredoxin-like domain rhaM PF05336.13 CCF46936.1 - 2.2e-35 121.0 0.4 2.6e-35 120.8 0.4 1.1 1 0 0 1 1 1 1 L-rhamnose mutarotase CtsR_C PF17727.1 CCF46938.1 - 0.042 14.0 0.1 0.091 12.9 0.1 1.5 1 0 0 1 1 1 0 CtsR C-terminal dimerization domain ArsA_ATPase PF02374.15 CCF46939.1 - 3.4e-45 154.5 1.5 3.9e-45 154.4 1.5 1.0 1 0 0 1 1 1 1 Anion-transporting ATPase RecG_N PF17190.4 CCF46939.1 - 0.15 12.8 3.7 0.21 12.4 0.2 2.3 2 1 0 2 2 2 0 RecG N-terminal helical domain SatD PF16264.5 CCF46939.1 - 0.16 11.5 0.1 4 7.0 0.0 2.0 2 0 0 2 2 2 0 SatD family (SatD) TraT PF05818.12 CCF46940.1 - 3.1 7.4 4.3 4.1 7.0 4.3 1.2 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein Fungal_trans PF04082.18 CCF46941.1 - 3.6e-22 78.7 0.6 6.9e-21 74.5 0.0 2.1 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF46941.1 - 1.9e-06 27.9 10.5 3.9e-06 26.9 10.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2722 PF10846.8 CCF46941.1 - 0.0014 17.6 13.6 0.0022 17.0 13.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) TFIIA PF03153.13 CCF46941.1 - 0.0026 17.8 10.7 0.0035 17.4 10.7 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit EPL1 PF10513.9 CCF46941.1 - 0.0061 17.0 0.9 0.012 16.0 0.9 1.5 1 0 0 1 1 1 1 Enhancer of polycomb-like Spt20 PF12090.8 CCF46941.1 - 0.023 14.3 19.8 0.037 13.6 19.8 1.2 1 0 0 1 1 1 0 Spt20 family DUF775 PF05603.12 CCF46941.1 - 0.047 13.2 1.8 0.074 12.6 1.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF775) SLC12 PF03522.15 CCF46941.1 - 0.059 12.4 3.2 0.081 11.9 3.2 1.1 1 0 0 1 1 1 0 Solute carrier family 12 TERB2 PF15101.6 CCF46941.1 - 0.067 13.2 5.7 0.13 12.3 5.7 1.4 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Kei1 PF08552.11 CCF46941.1 - 0.098 12.5 1.2 0.2 11.5 1.2 1.4 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Hydin_ADK PF17213.3 CCF46941.1 - 0.12 12.7 8.0 0.19 12.0 8.0 1.3 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Gal4_dimer PF03902.13 CCF46941.1 - 0.13 12.4 0.9 0.28 11.4 0.9 1.5 1 0 0 1 1 1 0 Gal4-like dimerisation domain Presenilin PF01080.17 CCF46941.1 - 0.17 10.6 4.8 0.22 10.2 4.8 1.2 1 0 0 1 1 1 0 Presenilin Suf PF05843.14 CCF46941.1 - 0.24 11.3 6.4 0.34 10.9 6.4 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Connexin PF00029.19 CCF46941.1 - 0.4 10.4 2.0 0.71 9.6 2.0 1.3 1 0 0 1 1 1 0 Connexin Androgen_recep PF02166.16 CCF46941.1 - 0.43 9.4 13.8 0.61 8.9 13.8 1.1 1 0 0 1 1 1 0 Androgen receptor EIIBC-GUT_N PF03612.14 CCF46941.1 - 2.8 7.7 4.9 4.6 6.9 4.9 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DUF4834 PF16118.5 CCF46941.1 - 3.7 8.6 11.0 9.2 7.3 10.5 1.9 2 0 0 2 2 1 0 Domain of unknown function (DUF4834) Hid1 PF12722.7 CCF46941.1 - 8.4 4.4 7.9 11 4.0 7.9 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Glyco_trans_2_3 PF13632.6 CCF46942.1 - 1.3e-19 70.9 0.4 2e-19 70.3 0.4 1.3 1 0 0 1 1 1 1 Glycosyl transferase family group 2 CPCFC PF17223.3 CCF46943.1 - 0.17 11.7 4.2 0.31 10.8 4.2 1.4 1 0 0 1 1 1 0 Cuticle protein CPCFC Smim3 PF17307.2 CCF46944.1 - 0.003 17.0 0.2 0.0067 15.9 0.2 1.5 1 0 0 1 1 1 1 Small integral membrane protein 3 HxlR PF01638.17 CCF46945.1 - 0.0018 18.1 0.0 0.0028 17.5 0.0 1.3 1 0 0 1 1 1 1 HxlR-like helix-turn-helix Dimerisation PF08100.11 CCF46945.1 - 0.0032 17.5 0.1 0.0061 16.6 0.1 1.5 1 0 0 1 1 1 1 Dimerisation domain XPG_N PF00752.17 CCF46946.1 - 6.3e-34 116.5 0.0 1.4e-33 115.3 0.0 1.6 1 0 0 1 1 1 1 XPG N-terminal domain UIM PF02809.20 CCF46946.1 - 0.0028 17.4 0.5 0.0028 17.4 0.5 4.1 5 0 0 5 5 5 2 Ubiquitin interaction motif LSM PF01423.22 CCF46947.1 - 1.7e-09 37.2 0.0 2.5e-09 36.7 0.0 1.3 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 CCF46947.1 - 0.007 16.5 0.0 0.015 15.5 0.0 1.6 1 1 0 1 1 1 1 Ataxin 2 SM domain Pil1 PF13805.6 CCF46948.1 - 1.2e-112 375.7 2.8 1.6e-112 375.3 2.8 1.1 1 0 0 1 1 1 1 Eisosome component PIL1 Octopine_DH PF02317.17 CCF46948.1 - 0.14 12.3 0.5 0.54 10.3 0.5 1.9 1 1 0 1 1 1 0 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain FAM92 PF06730.11 CCF46948.1 - 0.14 11.6 3.1 0.44 9.9 3.1 1.8 1 1 0 1 1 1 0 FAM92 protein DUF1263 PF06882.12 CCF46948.1 - 0.15 12.1 0.1 0.64 10.1 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1263) EZH2_N PF18601.1 CCF46949.1 - 1.5e-29 102.2 0.2 3.1e-29 101.1 0.2 1.6 1 0 0 1 1 1 1 EZH2 N-terminal domain Ezh2_MCSS PF18600.1 CCF46949.1 - 1.9e-20 72.2 4.9 3.4e-20 71.4 4.9 1.4 1 0 0 1 1 1 1 MCSS domain Phage_cap_P2 PF05125.12 CCF46949.1 - 0.0082 15.2 0.0 0.013 14.5 0.0 1.2 1 0 0 1 1 1 1 Phage major capsid protein, P2 family GPI2 PF06432.11 CCF46954.1 - 6.1e-52 176.8 5.0 7.1e-52 176.6 5.0 1.0 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase Herpes_US9 PF06072.11 CCF46954.1 - 0.045 13.6 0.7 0.074 12.9 0.7 1.3 1 0 0 1 1 1 0 Alphaherpesvirus tegument protein US9 ABC2_membrane PF01061.24 CCF46954.1 - 0.16 11.4 8.8 0.052 13.0 3.9 1.9 1 1 1 2 2 2 0 ABC-2 type transporter TMEM141 PF15110.6 CCF46954.1 - 0.55 10.8 3.7 2.2 8.9 1.1 2.5 1 1 2 3 3 3 0 TMEM141 protein family RNase_H PF00075.24 CCF46955.1 - 2.5e-14 53.7 0.0 3.2e-14 53.3 0.0 1.1 1 0 0 1 1 1 1 RNase H RVT_3 PF13456.6 CCF46955.1 - 0.0049 16.7 0.1 0.41 10.4 0.0 2.4 2 1 0 2 2 2 2 Reverse transcriptase-like Pectate_lyase_3 PF12708.7 CCF46956.1 - 1.2e-77 260.6 13.6 1.7e-67 227.4 9.5 2.2 2 0 0 2 2 2 2 Pectate lyase superfamily protein End_N_terminal PF12218.8 CCF46956.1 - 0.03 14.0 0.0 0.086 12.6 0.0 1.8 1 0 0 1 1 1 0 N terminal extension of bacteriophage endosialidase FMO-like PF00743.19 CCF46957.1 - 1e-36 126.5 0.0 7.7e-23 80.7 0.0 3.0 3 0 0 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 CCF46957.1 - 2e-16 60.2 0.0 2.9e-10 39.9 0.0 3.1 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CCF46957.1 - 1.3e-13 50.8 0.0 4.5e-13 49.1 0.0 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CCF46957.1 - 3.2e-10 40.2 0.0 1.1e-07 32.0 0.1 2.6 2 1 0 2 2 2 1 FAD-NAD(P)-binding Thi4 PF01946.17 CCF46957.1 - 4.9e-08 32.5 0.1 4.3e-05 22.9 0.0 2.3 2 0 0 2 2 2 2 Thi4 family DAO PF01266.24 CCF46957.1 - 6.7e-08 32.5 0.0 0.0084 15.7 0.0 3.1 3 0 0 3 3 3 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CCF46957.1 - 1.1e-07 31.9 0.0 2.5e-07 30.8 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 CCF46957.1 - 6.1e-06 25.6 0.0 0.0029 16.8 0.0 2.8 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Amino_oxidase PF01593.24 CCF46957.1 - 7.7e-05 22.2 0.0 0.0018 17.7 0.0 2.3 1 1 1 2 2 2 1 Flavin containing amine oxidoreductase FAD_oxidored PF12831.7 CCF46957.1 - 0.00014 21.3 0.0 0.0002 20.8 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 CCF46957.1 - 0.00048 20.6 0.3 0.014 15.9 0.0 2.8 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Glu_dehyd_C PF16912.5 CCF46957.1 - 0.0073 15.8 0.0 0.052 13.0 0.0 2.1 2 0 0 2 2 2 1 Glucose dehydrogenase C-terminus HI0933_like PF03486.14 CCF46957.1 - 0.0088 14.8 0.3 0.019 13.7 0.0 1.7 2 0 0 2 2 2 1 HI0933-like protein FAD_binding_2 PF00890.24 CCF46957.1 - 0.048 12.7 0.0 0.46 9.5 0.0 2.0 2 0 0 2 2 2 0 FAD binding domain FAD_binding_3 PF01494.19 CCF46957.1 - 0.064 12.5 0.0 0.15 11.3 0.0 1.6 1 0 0 1 1 1 0 FAD binding domain Shikimate_DH PF01488.20 CCF46957.1 - 0.065 13.3 0.0 0.62 10.1 0.0 2.1 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Oxidored_FMN PF00724.20 CCF46958.1 - 0.00071 18.9 0.0 0.00088 18.6 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family MFS_1 PF07690.16 CCF46960.1 - 1.1e-30 106.8 10.8 1.1e-30 106.8 10.8 1.6 1 1 1 2 2 2 2 Major Facilitator Superfamily LVIVD PF08309.11 CCF46961.1 - 0.0008 18.7 0.4 0.77 9.1 0.2 2.7 2 0 0 2 2 2 2 LVIVD repeat DUF3116 PF11313.8 CCF46962.1 - 0.087 12.7 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3116) DnaJ_C PF01556.18 CCF46963.1 - 0.0054 16.8 0.1 0.0065 16.6 0.1 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain HMGL-like PF00682.19 CCF46965.1 - 1.2e-36 126.6 0.1 2e-36 126.0 0.1 1.3 1 0 0 1 1 1 1 HMGL-like DarA_N PF18788.1 CCF46966.1 - 0.12 12.5 0.0 0.13 12.3 0.0 1.2 1 0 0 1 1 1 0 Defence against restriction A N-terminal Amidohydro_1 PF01979.20 CCF46967.1 - 5e-10 39.2 0.0 1.5e-09 37.7 0.0 1.6 2 0 0 2 2 2 1 Amidohydrolase family Amidohydro_3 PF07969.11 CCF46967.1 - 0.00021 20.9 0.2 0.00034 20.2 0.2 1.3 1 0 0 1 1 1 1 Amidohydrolase family TraQ PF09679.10 CCF46969.1 - 0.023 14.6 0.2 0.044 13.7 0.2 1.4 1 0 0 1 1 1 0 Type-F conjugative transfer system pilin chaperone (TraQ) TPR_4 PF07721.14 CCF46969.1 - 0.13 12.9 0.4 0.13 12.9 0.4 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat FGGY_C PF02782.16 CCF46971.1 - 1.2e-45 155.7 0.5 1.9e-45 155.0 0.5 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 CCF46971.1 - 4.4e-24 85.4 0.3 1e-22 80.9 0.3 2.7 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain BcrAD_BadFG PF01869.20 CCF46971.1 - 0.072 12.6 0.1 0.22 11.0 0.0 1.7 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family VTC PF09359.10 CCF46972.1 - 4.7e-90 301.7 1.2 8.8e-90 300.8 1.2 1.4 1 0 0 1 1 1 1 VTC domain DUF202 PF02656.15 CCF46972.1 - 1.7e-12 47.6 2.1 1.7e-12 47.6 2.1 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF202) SPX PF03105.19 CCF46972.1 - 2.6e-07 30.9 5.6 0.0002 21.4 0.9 4.3 2 2 1 4 4 4 2 SPX domain KASH_CCD PF14662.6 CCF46972.1 - 0.34 10.7 5.5 2.8 7.7 0.3 2.3 2 0 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH NPV_P10 PF05531.12 CCF46972.1 - 0.49 10.9 2.0 9.1 6.8 0.1 2.7 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein TauD PF02668.16 CCF46973.1 - 6.7e-23 81.8 0.0 9.7e-23 81.3 0.0 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family PK_C PF02887.16 CCF46973.1 - 0.11 12.7 0.1 1.5 9.1 0.0 2.2 2 0 0 2 2 2 0 Pyruvate kinase, alpha/beta domain GH131_N PF18271.1 CCF46974.1 - 6.1e-80 268.6 0.0 6.9e-80 268.4 0.0 1.0 1 0 0 1 1 1 1 Glycoside hydrolase 131 catalytic N-terminal domain Cyto_heme_lyase PF01265.17 CCF46978.1 - 5.5e-115 384.0 0.2 6.4e-115 383.7 0.2 1.0 1 0 0 1 1 1 1 Cytochrome c/c1 heme lyase CorA PF01544.18 CCF46980.1 - 0.00012 21.5 1.6 0.00014 21.3 1.6 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein DUF2434 PF10361.9 CCF46980.1 - 0.072 12.1 4.7 0.092 11.7 4.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2434) Gram_pos_anchor PF00746.21 CCF46980.1 - 0.1 12.6 0.3 0.19 11.7 0.3 1.5 1 0 0 1 1 1 0 LPXTG cell wall anchor motif Pullulanase_Ins PF18494.1 CCF46980.1 - 0.11 13.0 0.2 0.18 12.3 0.2 1.3 1 0 0 1 1 1 0 Pullulanase Ins domain Cellulase PF00150.18 CCF46982.1 - 5.2e-08 32.6 0.0 7.9e-08 32.1 0.0 1.2 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Amidohydro_3 PF07969.11 CCF46983.1 - 2.7e-15 56.8 0.0 2.9e-15 56.7 0.0 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_1 PF01979.20 CCF46983.1 - 1.4e-10 41.1 0.0 1.6e-10 40.9 0.0 1.0 1 0 0 1 1 1 1 Amidohydrolase family Pectinesterase PF01095.19 CCF46985.1 - 2e-09 36.6 1.1 2.3e-09 36.4 1.1 1.0 1 0 0 1 1 1 1 Pectinesterase TFIID-18kDa PF02269.16 CCF46987.1 - 1.7e-17 63.2 0.0 2.9e-17 62.5 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit Bromo_TP PF07524.13 CCF46987.1 - 0.00015 21.7 0.0 0.00031 20.7 0.0 1.5 1 0 0 1 1 1 1 Bromodomain associated CBFD_NFYB_HMF PF00808.23 CCF46987.1 - 0.0016 18.7 0.2 0.013 15.8 0.0 2.2 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 CCF46987.1 - 0.005 17.2 0.1 0.035 14.5 0.0 2.1 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 CCF46987.1 - 0.0097 16.3 0.0 0.019 15.3 0.0 1.5 1 0 0 1 1 1 1 CENP-S protein Pes-10 PF07149.11 CCF46987.1 - 0.59 9.1 6.0 0.81 8.7 6.0 1.1 1 0 0 1 1 1 0 Pes-10 DUF1242 PF06842.12 CCF46988.1 - 5.4e-15 54.9 0.6 6.3e-15 54.7 0.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1242) WBP-1 PF11669.8 CCF46988.1 - 0.03 15.0 0.2 0.03 15.0 0.2 1.0 1 0 0 1 1 1 0 WW domain-binding protein 1 Tcp11 PF05794.13 CCF46989.1 - 1.2e-107 360.8 0.0 2.1e-107 360.0 0.0 1.4 1 0 0 1 1 1 1 T-complex protein 11 DUF3584 PF12128.8 CCF46989.1 - 0.16 9.4 0.0 0.29 8.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Glyco_hydro_11 PF00457.17 CCF46991.1 - 8.4e-77 256.8 17.6 9.6e-77 256.6 17.6 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 11 Enolase_like_N PF18374.1 CCF46993.1 - 0.085 12.2 0.4 0.13 11.6 0.4 1.2 1 0 0 1 1 1 0 Enolase N-terminal domain-like HTH_psq PF05225.16 CCF46995.1 - 1.1e-08 34.7 0.0 2.2e-08 33.7 0.0 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.16 CCF46995.1 - 7.6e-07 29.1 0.1 2.2e-06 27.6 0.0 1.9 1 1 1 2 2 2 1 Tc5 transposase DNA-binding domain Fn3-like PF14310.6 CCF46996.1 - 4.2e-22 78.0 0.7 8.7e-22 77.0 0.7 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain DUF11 PF01345.18 CCF46996.1 - 0.0099 16.2 0.9 0.022 15.0 0.7 1.7 1 1 0 1 1 1 1 Domain of unknown function DUF11 Msg2_C PF12373.8 CCF46996.1 - 0.1 12.0 1.5 2.9 7.4 0.1 2.6 2 0 0 2 2 2 0 Major surface glycoprotein 2 C terminal DUF4352 PF11611.8 CCF46996.1 - 0.15 12.3 0.0 0.36 11.1 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4352) SnoaL_4 PF13577.6 CCF46997.1 - 0.096 12.8 0.8 12 6.0 0.1 2.6 1 1 2 3 3 3 0 SnoaL-like domain TspO_MBR PF03073.15 CCF46998.1 - 0.034 14.2 0.5 0.034 14.2 0.5 1.6 2 0 0 2 2 2 0 TspO/MBR family Cytochrom_B562 PF07361.11 CCF46999.1 - 0.38 11.4 12.8 0.12 13.1 8.3 2.1 1 1 1 2 2 2 0 Cytochrome b562 Glyco_hydro_61 PF03443.14 CCF47000.1 - 1.2e-58 198.5 0.0 1.4e-58 198.2 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 NPCBM_assoc PF10633.9 CCF47000.1 - 0.012 15.8 0.2 0.38 11.0 0.0 2.8 3 0 0 3 3 3 0 NPCBM-associated, NEW3 domain of alpha-galactosidase dbPDZ_assoc PF16610.5 CCF47000.1 - 0.025 14.8 0.0 0.058 13.6 0.0 1.5 1 0 0 1 1 1 0 Unstructured region between two PDZ domains on Dlg5 SUV3_C PF12513.8 CCF47001.1 - 2.9e-17 62.3 0.2 6.5e-17 61.2 0.2 1.7 1 0 0 1 1 1 1 Mitochondrial degradasome RNA helicase subunit C terminal Suv3_C_1 PF18147.1 CCF47001.1 - 6.3e-10 38.8 1.9 6.7e-10 38.7 0.1 2.0 2 0 0 2 2 2 1 Suv3 C-terminal domain 1 Helicase_C PF00271.31 CCF47001.1 - 3.1e-05 24.3 0.0 0.00011 22.5 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4771 PF15995.5 CCF47001.1 - 0.13 12.5 0.2 1.2 9.4 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4771) HV_small_capsid PF17086.5 CCF47002.1 - 0.15 12.3 0.1 0.31 11.3 0.1 1.4 1 0 0 1 1 1 0 Small capsid protein of Herpesviridae REC1 PF18501.1 CCF47006.1 - 0.26 11.1 2.1 0.46 10.3 2.1 1.4 1 0 0 1 1 1 0 Alpha helical recognition lobe domain MFS_1 PF07690.16 CCF47007.1 - 1.5e-24 86.6 57.1 3e-24 85.6 43.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily PNTB_4TM PF12769.7 CCF47007.1 - 1.9 9.0 8.8 0.99 9.9 5.2 2.5 2 0 0 2 2 2 0 4TM region of pyridine nucleotide transhydrogenase, mitoch NAD_binding_10 PF13460.6 CCF47008.1 - 1.2e-22 80.7 0.3 2.6e-22 79.6 0.2 1.6 1 1 1 2 2 2 1 NAD(P)H-binding NmrA PF05368.13 CCF47008.1 - 4.1e-21 75.6 0.4 5.6e-21 75.2 0.4 1.1 1 0 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 CCF47008.1 - 1.4e-07 31.2 0.0 7.4e-06 25.6 0.1 2.5 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 CCF47008.1 - 0.0013 19.2 1.1 0.0029 18.0 1.1 1.7 1 1 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain RmlD_sub_bind PF04321.17 CCF47008.1 - 0.0018 17.4 0.0 0.0052 15.9 0.1 1.7 2 0 0 2 2 2 1 RmlD substrate binding domain CoA_binding_2 PF13380.6 CCF47008.1 - 0.014 15.9 0.9 0.045 14.2 0.9 1.9 1 1 0 1 1 1 0 CoA binding domain DapB_N PF01113.20 CCF47008.1 - 0.029 14.5 0.4 0.074 13.2 0.4 1.8 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus adh_short PF00106.25 CCF47008.1 - 0.031 13.7 0.8 0.05 13.1 0.3 1.7 2 0 0 2 2 2 0 short chain dehydrogenase FAD_binding_3 PF01494.19 CCF47008.1 - 0.064 12.5 0.4 0.12 11.6 0.4 1.4 1 0 0 1 1 1 0 FAD binding domain THF_DHG_CYH_C PF02882.19 CCF47008.1 - 0.065 12.6 2.0 0.12 11.6 0.9 2.0 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 3HCDH_N PF02737.18 CCF47008.1 - 0.1 12.5 0.3 0.19 11.6 0.3 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DFP PF04127.15 CCF47008.1 - 0.12 12.2 1.4 0.25 11.1 1.4 1.5 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein NAD_binding_7 PF13241.6 CCF47008.1 - 0.17 12.4 0.7 0.33 11.4 0.7 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding Trp_DMAT PF11991.8 CCF47009.1 - 3.3e-61 207.7 0.0 3.8e-61 207.5 0.0 1.0 1 0 0 1 1 1 1 Tryptophan dimethylallyltransferase ABC_membrane PF00664.23 CCF47013.1 - 0.00055 19.7 1.3 0.00055 19.7 1.3 2.2 2 1 0 3 3 3 1 ABC transporter transmembrane region PGA2 PF07543.12 CCF47014.1 - 0.013 15.5 9.1 0.016 15.2 9.1 1.1 1 0 0 1 1 1 0 Protein trafficking PGA2 MFS_1 PF07690.16 CCF47015.1 - 0.002 17.1 0.4 0.0027 16.7 0.4 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily UCH PF00443.29 CCF47017.1 - 6e-67 225.8 0.0 8.5e-67 225.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CCF47017.1 - 9.4e-10 38.6 0.0 0.0012 18.5 0.0 3.1 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 CCF47017.1 - 2.2e-07 31.4 0.0 5e-07 30.2 0.0 1.7 1 0 0 1 1 1 1 DUSP domain Nit_Regul_Hom PF10126.9 CCF47019.1 - 0.072 13.1 0.0 0.075 13.1 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein, homolog of nitrogen regulatory protein PII CoA_transf_3 PF02515.17 CCF47021.1 - 1.4e-18 67.2 0.2 4.8e-16 58.8 0.1 2.3 2 0 0 2 2 2 2 CoA-transferase family III Pyr_redox_2 PF07992.14 CCF47028.1 - 3.5e-23 82.3 0.0 4.9e-23 81.8 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCF47028.1 - 3.1e-13 50.1 0.0 5.5e-13 49.3 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CCF47028.1 - 4e-05 22.9 0.0 5.9e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 CCF47028.1 - 5.5e-05 22.9 0.0 0.03 13.9 0.0 2.1 2 0 0 2 2 2 2 FAD dependent oxidoreductase Trp_halogenase PF04820.14 CCF47028.1 - 6.3e-05 22.0 0.0 0.25 10.1 0.1 2.1 1 1 1 2 2 2 2 Tryptophan halogenase Lycopene_cycl PF05834.12 CCF47028.1 - 0.00044 19.4 0.1 0.27 10.3 0.1 2.4 2 1 1 3 3 3 2 Lycopene cyclase protein Pyr_redox_3 PF13738.6 CCF47028.1 - 0.0019 17.5 0.0 0.0043 16.3 0.0 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CCF47028.1 - 0.027 14.5 0.1 3.8 7.5 0.0 2.3 1 1 1 2 2 2 0 FAD-NAD(P)-binding NAD_binding_7 PF13241.6 CCF47028.1 - 0.029 14.8 0.1 0.18 12.3 0.0 2.0 2 0 0 2 2 2 0 Putative NAD(P)-binding TrkA_N PF02254.18 CCF47028.1 - 0.14 12.5 0.0 0.29 11.4 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain Asparaginase PF00710.20 CCF47029.1 - 5.5e-31 107.6 0.0 7.5e-31 107.2 0.0 1.1 1 0 0 1 1 1 1 Asparaginase, N-terminal SR-25 PF10500.9 CCF47030.1 - 1.7 8.2 13.9 2.4 7.7 13.9 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Spc7_N PF15402.6 CCF47030.1 - 1.8 6.7 7.7 2.3 6.4 7.7 1.0 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 Pectate_lyase PF03211.13 CCF47031.1 - 3.9e-75 251.9 11.2 4.6e-75 251.6 11.2 1.0 1 0 0 1 1 1 1 Pectate lyase PC4 PF02229.16 CCF47031.1 - 0.064 12.9 0.2 0.12 12.0 0.2 1.4 1 0 0 1 1 1 0 Transcriptional Coactivator p15 (PC4) Beta_elim_lyase PF01212.21 CCF47032.1 - 1e-23 84.1 0.0 1.2e-23 83.9 0.0 1.0 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 CCF47032.1 - 0.003 16.9 0.0 0.0036 16.7 0.0 1.1 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 CCF47032.1 - 0.0054 15.3 0.0 0.007 14.9 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme HR1 PF02185.16 CCF47033.1 - 0.005 16.9 2.5 0.0081 16.3 2.5 1.4 1 0 0 1 1 1 1 Hr1 repeat Phage_lysis PF03245.13 CCF47033.1 - 0.038 14.1 5.9 1.1 9.4 5.9 2.1 1 1 0 1 1 1 0 Bacteriophage Rz lysis protein Toprim_3 PF13362.6 CCF47033.1 - 0.072 13.5 0.4 0.092 13.1 0.4 1.2 1 0 0 1 1 1 0 Toprim domain MCLC PF05934.11 CCF47033.1 - 0.079 11.7 0.4 0.079 11.7 0.4 1.0 1 0 0 1 1 1 0 Mid-1-related chloride channel (MCLC) WD40 PF00400.32 CCF47035.1 - 1.3e-06 29.0 0.1 0.88 10.6 0.0 4.9 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF47035.1 - 7.8e-06 26.1 0.0 0.19 12.0 0.0 4.9 4 2 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 CCF47035.1 - 0.053 13.5 0.2 0.56 10.2 0.0 2.7 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat PfkB PF00294.24 CCF47036.1 - 1.4e-09 37.7 0.1 6.2e-09 35.6 0.1 1.8 2 0 0 2 2 2 1 pfkB family carbohydrate kinase RTA1 PF04479.13 CCF47037.1 - 2.1e-69 233.3 9.8 2.6e-69 233.0 9.8 1.2 1 0 0 1 1 1 1 RTA1 like protein Rep_fac_C PF08542.11 CCF47039.1 - 7e-22 77.6 0.0 1.4e-21 76.7 0.0 1.6 1 0 0 1 1 1 1 Replication factor C C-terminal domain AAA PF00004.29 CCF47039.1 - 4e-17 62.9 0.0 1.7e-16 60.8 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 CCF47039.1 - 9.8e-11 41.7 0.0 8.6e-10 38.6 0.0 2.2 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA_assoc_2 PF16193.5 CCF47039.1 - 1.8e-05 25.0 0.1 5.1e-05 23.5 0.1 1.8 1 0 0 1 1 1 1 AAA C-terminal domain AAA_22 PF13401.6 CCF47039.1 - 2.4e-05 24.6 0.1 0.00055 20.2 0.0 2.7 2 2 0 2 2 2 1 AAA domain DNA_pol3_delta PF06144.13 CCF47039.1 - 3.2e-05 23.8 0.0 6e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_14 PF13173.6 CCF47039.1 - 0.00027 21.0 0.0 0.00055 20.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 CCF47039.1 - 0.00036 20.4 0.1 0.0012 18.7 0.0 1.7 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 CCF47039.1 - 0.00088 19.7 0.1 0.028 14.8 0.0 2.5 1 1 1 2 2 2 1 AAA ATPase domain DUF2075 PF09848.9 CCF47039.1 - 0.0024 17.2 0.0 0.0053 16.1 0.0 1.6 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_24 PF13479.6 CCF47039.1 - 0.0052 16.5 0.0 0.014 15.2 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 CCF47039.1 - 0.0057 16.9 0.0 0.01 16.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 CCF47039.1 - 0.0064 16.5 0.2 0.039 13.9 0.1 2.3 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 CCF47039.1 - 0.0075 16.0 0.0 0.027 14.2 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 CCF47039.1 - 0.0087 16.6 0.0 0.025 15.1 0.0 1.9 1 1 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 CCF47039.1 - 0.0092 15.4 0.0 0.47 9.8 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 CCF47039.1 - 0.021 15.2 0.0 0.055 13.9 0.0 1.7 1 1 0 1 1 1 0 RNA helicase AAA_19 PF13245.6 CCF47039.1 - 0.025 14.9 0.1 0.18 12.1 0.1 2.2 1 1 0 1 1 1 0 AAA domain RuvB_N PF05496.12 CCF47039.1 - 0.039 13.7 0.1 0.17 11.6 0.0 2.1 3 0 0 3 3 3 0 Holliday junction DNA helicase RuvB P-loop domain AAA_23 PF13476.6 CCF47039.1 - 0.049 14.1 0.0 0.062 13.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 CCF47039.1 - 0.08 12.5 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region PhoH PF02562.16 CCF47039.1 - 0.11 11.9 0.0 8 5.8 0.0 2.9 3 0 0 3 3 3 0 PhoH-like protein Rad17 PF03215.15 CCF47039.1 - 0.12 12.2 0.1 0.32 10.9 0.1 1.8 1 1 0 1 1 1 0 Rad17 P-loop domain DEAD PF00270.29 CCF47039.1 - 0.13 12.0 0.1 0.63 9.8 0.0 2.1 1 1 1 2 2 2 0 DEAD/DEAH box helicase Sortilin-Vps10 PF15902.5 CCF47040.1 - 6.1e-09 35.2 0.0 0.00064 18.6 0.0 2.9 2 1 1 3 3 3 2 Sortilin, neurotensin receptor 3, BNR PF02012.20 CCF47040.1 - 2.7e-06 26.5 2.8 0.24 11.5 0.0 4.8 3 0 0 3 3 3 2 BNR/Asp-box repeat DUF4185 PF13810.6 CCF47040.1 - 0.0015 17.8 0.3 0.12 11.6 0.1 2.8 2 1 1 3 3 3 1 Domain of unknown function (DUF4185) Kelch_6 PF13964.6 CCF47040.1 - 0.093 13.1 1.1 20 5.7 0.1 4.3 4 1 1 5 5 5 0 Kelch motif DUF2452 PF10504.9 CCF47040.1 - 0.12 11.9 0.0 0.19 11.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2452) BNR_2 PF13088.6 CCF47040.1 - 0.12 11.6 1.1 15 4.7 0.1 2.8 1 1 2 3 3 3 0 BNR repeat-like domain Kelch_4 PF13418.6 CCF47040.1 - 0.43 10.6 4.7 0.46 10.5 0.5 3.0 2 1 1 3 3 3 0 Galactose oxidase, central domain PsiA PF06952.11 CCF47041.1 - 0.31 10.3 2.2 0.37 10.0 2.2 1.1 1 0 0 1 1 1 0 PsiA protein Pkinase PF00069.25 CCF47043.1 - 1.5e-26 93.4 0.0 2e-26 92.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF47043.1 - 5.1e-19 68.6 0.0 6.6e-19 68.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CCF47043.1 - 0.00028 20.3 0.0 0.00046 19.6 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 CCF47043.1 - 0.013 14.3 0.0 0.019 13.8 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Kinase-like PF14531.6 CCF47043.1 - 0.085 12.2 0.0 0.25 10.6 0.0 1.6 2 0 0 2 2 2 0 Kinase-like Methyltransf_34 PF11312.8 CCF47044.1 - 1.1e-08 34.7 0.0 1.6e-08 34.2 0.0 1.2 1 0 0 1 1 1 1 Putative SAM-dependent methyltransferase DUF2880 PF11082.8 CCF47044.1 - 0.068 13.5 3.7 0.066 13.5 2.3 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2880) Cu_amine_oxid PF01179.20 CCF47045.1 - 5.8e-51 173.7 1.9 6.5e-51 173.5 1.9 1.0 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Xpo1 PF08389.12 CCF47046.1 - 4.8e-08 33.2 7.8 0.00019 21.5 0.0 4.3 5 0 0 5 5 5 2 Exportin 1-like protein IBN_N PF03810.19 CCF47046.1 - 0.00055 19.8 0.3 0.00055 19.8 0.3 3.3 3 0 0 3 3 3 1 Importin-beta N-terminal domain HEAT PF02985.22 CCF47046.1 - 0.01 16.0 0.8 19 5.9 0.1 4.7 5 0 0 5 5 5 0 HEAT repeat APC1_C PF18122.1 CCF47046.1 - 0.029 14.3 0.4 0.14 12.1 0.1 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex sub unit 1 C-terminal domain MMS19_N PF14500.6 CCF47046.1 - 0.035 13.7 0.5 0.65 9.5 0.1 2.4 2 0 0 2 2 2 0 Dos2-interacting transcription regulator of RNA-Pol-II IFRD PF05004.13 CCF47046.1 - 0.089 11.9 0.1 0.26 10.4 0.0 1.8 2 0 0 2 2 2 0 Interferon-related developmental regulator (IFRD) IPPT PF01715.17 CCF47046.1 - 0.094 12.5 0.0 0.21 11.4 0.0 1.6 1 0 0 1 1 1 0 IPP transferase Arm PF00514.23 CCF47046.1 - 0.14 12.3 0.2 0.42 10.7 0.2 1.8 1 0 0 1 1 1 0 Armadillo/beta-catenin-like repeat WD40 PF00400.32 CCF47047.1 - 0.0015 19.3 1.9 0.21 12.5 0.0 4.6 5 0 0 5 5 5 1 WD domain, G-beta repeat Sharpin_PH PF16764.5 CCF47047.1 - 0.15 11.8 0.0 4.5 7.0 0.0 2.3 2 0 0 2 2 2 0 Sharpin PH domain DUF1917 PF08939.10 CCF47048.1 - 1.1e-91 307.4 0.0 1.4e-91 307.0 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1917) Mhr1 PF12829.7 CCF47048.1 - 0.011 15.8 0.0 0.025 14.6 0.0 1.5 1 0 0 1 1 1 0 Transcriptional regulation of mitochondrial recombination Phage_GPD PF05954.11 CCF47048.1 - 0.1 11.9 0.0 0.19 11.0 0.0 1.3 1 0 0 1 1 1 0 Phage late control gene D protein (GPD) Aldedh PF00171.22 CCF47048.1 - 0.11 11.0 0.0 0.19 10.2 0.0 1.2 1 0 0 1 1 1 0 Aldehyde dehydrogenase family Acetyltransf_1 PF00583.25 CCF47049.1 - 3.6e-19 69.1 0.0 4.7e-19 68.7 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CCF47049.1 - 2.6e-11 43.5 0.0 3.7e-11 43.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CCF47049.1 - 6.4e-10 39.3 0.0 9.1e-10 38.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CCF47049.1 - 6.9e-10 38.8 0.0 1.1e-09 38.1 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.7 CCF47049.1 - 1.3e-07 32.3 0.0 1.6e-07 32.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 CCF47049.1 - 6.7e-07 29.4 0.0 1.1e-06 28.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 CCF47049.1 - 3.1e-06 26.9 0.0 3.8e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 CCF47049.1 - 0.0015 18.6 0.0 0.0029 17.7 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_18 PF18014.1 CCF47049.1 - 0.032 14.0 0.0 0.049 13.5 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DUF4105 PF13387.6 CCF47049.1 - 0.071 12.7 0.0 0.1 12.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4105) Acetyltransf_15 PF17013.5 CCF47049.1 - 0.095 12.2 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 Putative acetyl-transferase GNAT_acetyltran PF12746.7 CCF47049.1 - 0.14 11.7 0.0 0.19 11.3 0.0 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase AAR2 PF05282.11 CCF47051.1 - 1.5e-08 34.5 0.1 1.8e-08 34.2 0.1 1.1 1 0 0 1 1 1 1 AAR2 protein ADH_zinc_N PF00107.26 CCF47052.1 - 0.00027 20.9 0.0 0.00057 19.9 0.0 1.5 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCF47052.1 - 0.091 13.8 0.0 0.18 12.9 0.0 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase zf-rbx1 PF12678.7 CCF47053.1 - 7.2e-11 42.2 0.6 1.4e-10 41.3 0.6 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 CCF47053.1 - 1.7e-08 34.6 7.2 2.1e-08 34.4 3.0 2.2 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 CCF47053.1 - 1e-07 31.7 0.5 1.7e-07 31.0 0.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CCF47053.1 - 3.9e-07 30.0 3.6 1e-05 25.4 0.5 3.3 1 1 1 2 2 2 2 RING-type zinc-finger zf-C3HC4_2 PF13923.6 CCF47053.1 - 4.2e-07 29.7 6.2 4.7e-06 26.3 1.8 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CCF47053.1 - 4.8e-07 29.6 2.9 1.9e-06 27.7 3.0 1.9 1 1 1 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 CCF47053.1 - 5.8e-06 26.1 2.3 2e-05 24.3 2.4 1.8 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 CCF47053.1 - 8.2e-06 25.6 3.9 3.4e-05 23.6 1.2 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 CCF47053.1 - 0.00018 21.1 8.3 0.0017 18.0 0.6 3.3 3 0 0 3 3 3 1 RING-like zinc finger DUF2921 PF11145.8 CCF47053.1 - 0.00024 19.1 0.6 0.0003 18.8 0.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2921) Zn_ribbon_17 PF17120.5 CCF47053.1 - 0.0023 17.5 0.6 0.0023 17.5 0.6 1.7 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type zf-ANAPC11 PF12861.7 CCF47053.1 - 0.0094 16.0 0.9 0.0094 16.0 0.9 2.0 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.6 CCF47053.1 - 0.14 12.0 1.2 1.3 8.9 0.1 2.4 2 0 0 2 2 2 0 zf-RING of BARD1-type protein zf-C3H2C3 PF17122.5 CCF47053.1 - 0.24 11.5 3.3 2.5 8.2 1.7 2.5 2 1 0 2 2 2 0 Zinc-finger Tmpp129 PF10272.9 CCF47053.1 - 0.39 10.0 3.4 7.3 5.8 0.2 2.2 2 0 0 2 2 2 0 Putative transmembrane protein precursor FANCL_C PF11793.8 CCF47053.1 - 0.92 9.7 6.1 1.2 9.4 3.2 2.4 2 1 0 2 2 2 0 FANCL C-terminal domain RINGv PF12906.7 CCF47053.1 - 2 8.6 5.8 0.35 11.0 1.1 2.1 2 0 0 2 2 2 0 RING-variant domain APG5 PF04106.12 CCF47054.1 - 2.9e-21 76.1 0.1 9.5e-21 74.4 0.1 1.8 1 1 0 1 1 1 1 Autophagy protein Apg5 Serglycin PF04360.12 CCF47055.1 - 0.036 14.0 6.0 0.063 13.2 6.0 1.3 1 0 0 1 1 1 0 Serglycin KAR9 PF08580.10 CCF47055.1 - 1.3 7.5 4.8 1.6 7.1 4.8 1.1 1 0 0 1 1 1 0 Yeast cortical protein KAR9 Glyco_hydro_28 PF00295.17 CCF47056.1 - 3.8e-19 68.9 0.0 4.1e-18 65.5 0.0 2.0 1 1 0 1 1 1 1 Glycosyl hydrolases family 28 Pectate_lyase_3 PF12708.7 CCF47056.1 - 0.023 14.6 1.0 0.079 12.8 0.0 2.0 2 1 0 2 2 2 0 Pectate lyase superfamily protein Neur_chan_memb PF02932.16 CCF47057.1 - 0.016 15.3 2.6 0.021 14.9 2.6 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region RR_TM4-6 PF06459.12 CCF47057.1 - 0.064 13.1 4.6 0.081 12.7 4.6 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4366 PF14283.6 CCF47057.1 - 0.088 12.9 1.1 0.13 12.3 1.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) SOG2 PF10428.9 CCF47057.1 - 0.28 10.3 9.8 0.33 10.1 9.8 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein FAM60A PF15396.6 CCF47057.1 - 1.2 9.1 5.0 1.6 8.7 5.0 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Menin PF05053.13 CCF47057.1 - 2.4 6.4 6.2 3 6.1 6.2 1.0 1 0 0 1 1 1 0 Menin SLC12 PF03522.15 CCF47057.1 - 2.9 6.8 9.8 3.8 6.4 9.8 1.1 1 0 0 1 1 1 0 Solute carrier family 12 PAT1 PF09770.9 CCF47057.1 - 4.7 5.4 27.3 7.5 4.7 27.3 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Lin-8 PF03353.15 CCF47057.1 - 4.9 6.6 13.6 6.9 6.1 13.6 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist CNDH2_M PF16869.5 CCF47057.1 - 7.1 7.3 12.9 14 6.4 12.9 1.4 1 0 0 1 1 1 0 PF16858 Presenilin PF01080.17 CCF47057.1 - 9.9 4.8 15.9 14 4.4 15.9 1.1 1 0 0 1 1 1 0 Presenilin Lipase_GDSL PF00657.22 CCF47058.1 - 1.2e-11 44.9 0.0 1.6e-11 44.6 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 CCF47058.1 - 8.3e-08 32.8 1.6 3.5e-07 30.8 1.6 2.1 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Aminotran_1_2 PF00155.21 CCF47059.1 - 3.4e-64 217.3 0.0 4e-64 217.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Glyco_hydro_76 PF03663.14 CCF47060.1 - 3.1e-96 323.1 13.6 3.5e-96 322.9 13.6 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 CCF47060.1 - 0.21 10.6 7.8 0.16 11.1 0.2 2.9 2 1 1 3 3 3 0 Glycosyl Hydrolase Family 88 Peptidase_A22B PF04258.13 CCF47062.1 - 5.6e-46 157.3 3.0 2.1e-24 86.5 1.5 2.1 2 0 0 2 2 2 2 Signal peptide peptidase RPN2_C PF18004.1 CCF47062.1 - 0.54 10.2 9.0 14 5.6 8.2 2.2 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain FAM176 PF14851.6 CCF47062.1 - 6 6.5 6.6 15 5.3 2.8 2.5 3 0 0 3 3 3 0 FAM176 family RRP7 PF12923.7 CCF47063.1 - 0.15 12.2 0.9 0.18 11.9 0.9 1.3 1 1 0 1 1 1 0 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain IGF2_C PF08365.11 CCF47065.1 - 0.018 15.0 1.5 0.028 14.4 1.5 1.4 1 0 0 1 1 1 0 Insulin-like growth factor II E-peptide zf-Tim10_DDP PF02953.15 CCF47066.1 - 5.7e-18 64.3 3.1 7.6e-18 63.9 3.1 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Collagen PF01391.18 CCF47067.1 - 1.8 8.4 16.8 12 5.7 16.8 2.2 1 1 0 1 1 1 0 Collagen triple helix repeat (20 copies) FbpA PF05833.11 CCF47068.1 - 6.5e-05 21.9 0.0 7.7e-05 21.6 0.0 1.0 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) N1221 PF07923.13 CCF47070.1 - 0.005 16.1 0.2 0.0074 15.5 0.2 1.2 1 0 0 1 1 1 1 N1221-like protein DDE_1 PF03184.19 CCF47071.1 - 1.4e-34 119.2 0.0 3e-34 118.2 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 CCF47071.1 - 4e-05 23.4 0.0 0.00012 21.8 0.0 1.7 2 0 0 2 2 2 1 DDE superfamily endonuclease Glyco_hydro_2_C PF02836.17 CCF47072.1 - 0.033 13.3 0.0 0.05 12.7 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolases family 2, TIM barrel domain Voltage_CLC PF00654.20 CCF47074.1 - 1.3e-49 169.3 2.4 1.3e-49 169.3 2.4 2.2 1 1 0 2 2 2 1 Voltage gated chloride channel BofA PF07441.11 CCF47074.1 - 0.02 15.1 2.8 0.023 14.9 0.4 2.2 2 0 0 2 2 2 0 SigmaK-factor processing regulatory protein BofA ECF-ribofla_trS PF07155.12 CCF47074.1 - 0.16 11.9 5.9 5.7 6.9 0.4 3.0 3 0 0 3 3 3 0 ECF-type riboflavin transporter, S component CPBP PF02517.16 CCF47074.1 - 0.21 12.0 0.1 0.21 12.0 0.1 2.4 2 1 0 2 2 2 0 CPBP intramembrane metalloprotease MFS_1 PF07690.16 CCF47075.1 - 1.1e-32 113.4 35.3 1.1e-32 113.4 35.3 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily AAA_33 PF13671.6 CCF47076.1 - 5.8e-11 42.7 0.0 7.4e-11 42.4 0.0 1.0 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 CCF47076.1 - 1e-07 31.5 0.1 7.7e-07 28.6 0.1 1.9 1 1 0 1 1 1 1 Zeta toxin CoaE PF01121.20 CCF47076.1 - 0.0019 17.9 0.0 0.002 17.8 0.0 1.2 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA PF00004.29 CCF47076.1 - 0.0038 17.6 0.1 0.0067 16.9 0.1 1.4 1 1 1 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 CCF47076.1 - 0.0055 17.0 0.0 0.0085 16.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CCF47076.1 - 0.0058 17.2 0.1 0.01 16.4 0.1 1.6 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 CCF47076.1 - 0.011 15.4 0.0 0.011 15.4 0.0 1.2 1 0 0 1 1 1 0 AAA domain Hydin_ADK PF17213.3 CCF47076.1 - 0.012 15.9 0.1 0.015 15.6 0.1 1.1 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain KTI12 PF08433.10 CCF47076.1 - 0.018 14.5 0.0 0.026 14.0 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 Ploopntkinase3 PF18751.1 CCF47076.1 - 0.022 14.7 0.2 0.51 10.2 0.1 2.0 1 1 1 2 2 2 0 P-loop Nucleotide Kinase3 Viral_helicase1 PF01443.18 CCF47076.1 - 0.031 14.0 0.0 0.032 14.0 0.0 1.1 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase SKI PF01202.22 CCF47076.1 - 0.035 14.2 0.0 0.05 13.7 0.0 1.3 1 0 0 1 1 1 0 Shikimate kinase ABC_tran PF00005.27 CCF47076.1 - 0.039 14.5 0.0 0.049 14.1 0.0 1.2 1 0 0 1 1 1 0 ABC transporter AAA_22 PF13401.6 CCF47076.1 - 0.045 14.0 0.0 0.055 13.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain APS_kinase PF01583.20 CCF47076.1 - 0.047 13.6 0.0 0.05 13.5 0.0 1.2 1 0 0 1 1 1 0 Adenylylsulphate kinase Mg_chelatase PF01078.21 CCF47076.1 - 0.067 12.6 0.0 0.091 12.1 0.0 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_17 PF13207.6 CCF47076.1 - 0.084 13.3 0.0 0.14 12.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 CCF47076.1 - 0.096 13.1 0.0 0.14 12.6 0.0 1.3 1 0 0 1 1 1 0 RNA helicase CPT PF07931.12 CCF47076.1 - 0.1 12.4 0.1 1.4 8.7 0.0 2.0 1 1 1 2 2 2 0 Chloramphenicol phosphotransferase-like protein DUF815 PF05673.13 CCF47076.1 - 0.11 11.6 0.0 2.3 7.3 0.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF815) RTA1 PF04479.13 CCF47077.1 - 4.1e-55 186.6 7.5 4.1e-55 186.6 7.5 1.5 1 1 0 1 1 1 1 RTA1 like protein Zn_clus PF00172.18 CCF47078.1 - 5.5e-07 29.6 8.3 5.5e-07 29.6 8.3 2.0 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 CCF47078.1 - 0.00019 20.4 0.0 0.00032 19.6 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain p450 PF00067.22 CCF47079.1 - 0.00014 20.8 0.0 0.00016 20.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF3638 PF12340.8 CCF47080.1 - 3.7e-100 333.9 0.4 6.7e-100 333.1 0.4 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3638) DUF3645 PF12359.8 CCF47080.1 - 2.8e-18 65.0 2.0 9.9e-18 63.2 0.4 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF3645) peroxidase PF00141.23 CCF47082.1 - 1.3e-28 100.2 0.2 4.3e-28 98.6 0.2 1.6 1 1 0 1 1 1 1 Peroxidase Peroxidase_ext PF11895.8 CCF47082.1 - 4.7e-05 23.2 0.1 0.0001 22.2 0.1 1.6 1 0 0 1 1 1 1 Fungal peroxidase extension region DUF1929 PF09118.11 CCF47083.1 - 3.3e-24 85.0 0.1 8.4e-24 83.7 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1929) Kelch_6 PF13964.6 CCF47083.1 - 9.4e-16 57.5 4.0 0.00017 21.8 0.0 4.7 4 0 0 4 4 4 3 Kelch motif Kelch_1 PF01344.25 CCF47083.1 - 9.9e-16 57.1 4.1 1.2e-09 37.6 0.1 5.0 4 1 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 CCF47083.1 - 3.7e-12 45.7 2.6 6.4e-06 25.9 0.1 4.7 4 0 0 4 4 4 2 Kelch motif Glyoxal_oxid_N PF07250.11 CCF47083.1 - 3.7e-10 39.4 0.7 5.7e-07 29.0 0.3 2.3 2 0 0 2 2 2 2 Glyoxal oxidase N-terminus Kelch_4 PF13418.6 CCF47083.1 - 1.2e-07 31.6 5.9 0.0027 17.7 0.0 5.2 5 1 0 5 5 5 3 Galactose oxidase, central domain Kelch_5 PF13854.6 CCF47083.1 - 3.2e-07 30.2 4.3 0.2 11.7 0.5 4.7 4 0 0 4 4 4 2 Kelch motif Kelch_3 PF13415.6 CCF47083.1 - 0.012 15.9 0.9 1.1 9.6 0.0 3.8 3 1 0 3 3 3 0 Galactose oxidase, central domain AlphaC_N PF08829.10 CCF47083.1 - 0.1 12.7 0.0 0.35 10.9 0.0 2.0 1 0 0 1 1 1 0 Alpha C protein N terminal DUF5122 PF17164.4 CCF47083.1 - 2.6 8.4 10.0 10 6.5 0.3 4.2 5 0 0 5 5 5 0 Domain of unknown function (DUF5122) beta-propeller PIG-S PF10510.9 CCF47086.1 - 0.053 12.4 0.0 0.071 11.9 0.0 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-glycan biosynthesis class S protein LOR PF04525.12 CCF47087.1 - 6.8e-20 71.5 0.0 8.4e-20 71.1 0.0 1.0 1 0 0 1 1 1 1 LURP-one-related Phage_T7_tail PF03906.14 CCF47087.1 - 0.12 12.0 0.0 0.17 11.5 0.0 1.1 1 0 0 1 1 1 0 Phage T7 tail fibre protein UNC45-central PF11701.8 CCF47089.1 - 2.4e-56 189.9 0.1 4.3e-56 189.1 0.1 1.4 1 0 0 1 1 1 1 Myosin-binding striated muscle assembly central NACHT PF05729.12 CCF47091.1 - 0.0031 17.5 0.2 0.0059 16.5 0.2 1.5 1 0 0 1 1 1 1 NACHT domain KAP_NTPase PF07693.14 CCF47091.1 - 0.015 14.5 0.2 0.02 14.1 0.2 1.4 1 0 0 1 1 1 0 KAP family P-loop domain TcdB_N PF12918.7 CCF47091.1 - 0.021 15.1 0.4 14 6.1 0.0 3.1 2 0 0 2 2 2 0 TcdB toxin N-terminal helical domain DUF918 PF06033.11 CCF47091.1 - 0.07 13.1 0.0 0.17 11.9 0.0 1.6 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF918) Ank_2 PF12796.7 CCF47092.1 - 2.8e-43 146.4 3.6 9.8e-14 51.7 1.5 7.3 4 3 3 8 8 8 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CCF47092.1 - 8.4e-38 128.3 6.9 1.5e-11 44.5 0.1 7.4 4 2 4 8 8 8 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCF47092.1 - 1.8e-28 95.4 3.7 0.0035 17.7 0.0 10.5 11 0 0 11 11 11 6 Ankyrin repeat Ank PF00023.30 CCF47092.1 - 5.7e-28 96.1 9.7 9e-06 25.9 0.1 9.9 11 0 0 11 11 11 6 Ankyrin repeat Ank_5 PF13857.6 CCF47092.1 - 1.6e-22 79.2 3.5 6.2e-06 26.4 0.3 7.2 4 2 4 8 8 8 6 Ankyrin repeats (many copies) HTH_18 PF12833.7 CCF47092.1 - 0.11 12.8 0.0 0.37 11.1 0.0 1.9 1 0 0 1 1 1 0 Helix-turn-helix domain CcmH PF03918.14 CCF47092.1 - 0.12 11.6 0.0 5.6 6.2 0.0 2.8 3 0 0 3 3 3 0 Cytochrome C biogenesis protein p450 PF00067.22 CCF47093.1 - 4e-62 210.5 0.0 6.6e-62 209.7 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 2OG-FeII_Oxy PF03171.20 CCF47094.1 - 1.1e-20 74.0 0.0 2e-20 73.2 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 CCF47094.1 - 1.9e-17 64.1 0.0 2.9e-17 63.5 0.0 1.2 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal Abhydrolase_6 PF12697.7 CCF47094.1 - 0.37 11.3 10.0 0.85 10.2 9.8 1.7 1 1 0 1 1 1 0 Alpha/beta hydrolase family Gar1 PF04410.14 CCF47095.1 - 7.7e-24 84.2 0.0 8.2e-24 84.1 0.0 1.0 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region FoP_duplication PF13865.6 CCF47095.1 - 0.21 12.2 6.2 0.26 11.8 6.2 1.2 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 HAD_2 PF13419.6 CCF47096.1 - 1.7e-23 83.6 0.0 2.2e-23 83.2 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CCF47096.1 - 2.9e-11 44.1 0.0 1.1e-10 42.2 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CCF47096.1 - 6.7e-07 29.3 0.0 1.2e-06 28.5 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like NIF PF03031.18 CCF47096.1 - 0.00067 19.5 0.0 0.013 15.2 0.0 2.1 1 1 0 1 1 1 1 NLI interacting factor-like phosphatase Hydrolase_6 PF13344.6 CCF47096.1 - 0.031 14.4 0.0 0.85 9.8 0.0 2.3 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase UDPG_MGDP_dh_C PF03720.15 CCF47096.1 - 0.091 13.2 0.0 0.3 11.5 0.0 1.8 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain DUF4473 PF14747.6 CCF47097.1 - 0.0052 17.3 0.1 0.0056 17.2 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4473) PhoU_div PF01865.16 CCF47097.1 - 0.045 13.1 0.0 0.052 12.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF47 Pkinase PF00069.25 CCF47098.1 - 0.23 10.8 0.0 0.3 10.4 0.0 1.1 1 0 0 1 1 1 0 Protein kinase domain MLTR_LBD PF17765.1 CCF47099.1 - 0.064 13.4 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 MmyB-like transcription regulator ligand binding domain PAS_8 PF13188.7 CCF47099.1 - 0.069 13.2 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 PAS domain Snf7 PF03357.21 CCF47101.1 - 0.016 14.8 3.8 0.022 14.4 3.8 1.2 1 0 0 1 1 1 0 Snf7 DUF4090 PF13319.6 CCF47101.1 - 0.096 12.9 0.2 0.15 12.3 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4090) SRP_TPR_like PF17004.5 CCF47104.1 - 4.4e-21 75.1 6.1 1.5e-20 73.3 1.6 2.5 2 0 0 2 2 2 1 Putative TPR-like repeat SRP72 PF08492.12 CCF47104.1 - 8.2e-15 55.0 9.2 8.2e-15 55.0 9.2 2.5 2 0 0 2 2 2 1 SRP72 RNA-binding domain ANAPC3 PF12895.7 CCF47104.1 - 0.00028 21.0 8.1 0.0013 18.9 2.9 4.0 3 2 2 5 5 5 1 Anaphase-promoting complex, cyclosome, subunit 3 SPO22 PF08631.10 CCF47104.1 - 0.017 14.6 4.0 0.13 11.7 0.1 3.1 2 1 1 3 3 3 0 Meiosis protein SPO22/ZIP4 like TPR_14 PF13428.6 CCF47104.1 - 0.026 15.3 23.6 5.4 8.1 0.0 7.9 6 1 3 9 9 8 0 Tetratricopeptide repeat TPR_12 PF13424.6 CCF47104.1 - 0.14 12.5 21.6 5 7.5 0.2 6.6 6 2 1 7 7 7 0 Tetratricopeptide repeat GGA_N-GAT PF18308.1 CCF47104.1 - 0.14 11.8 2.1 0.68 9.6 0.1 2.6 2 0 0 2 2 2 0 GGA N-GAT domain TPR_10 PF13374.6 CCF47104.1 - 0.26 11.2 17.1 0.54 10.2 0.2 6.2 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_2 PF07719.17 CCF47104.1 - 0.56 10.4 25.4 1.4 9.3 0.7 5.8 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_11 PF13414.6 CCF47104.1 - 0.88 9.3 0.0 0.88 9.3 0.0 3.4 4 0 0 4 4 3 0 TPR repeat DUF4375 PF14300.6 CCF47104.1 - 3 8.1 4.7 42 4.4 0.0 4.1 4 1 1 5 5 4 0 Domain of unknown function (DUF4375) TPR_16 PF13432.6 CCF47104.1 - 4.2 8.1 25.1 0.89 10.2 2.5 5.4 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_1 PF00515.28 CCF47104.1 - 4.3 7.3 13.6 25 4.9 0.2 5.4 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_6 PF13174.6 CCF47104.1 - 6.2 7.7 7.1 59 4.6 0.1 5.1 6 0 0 6 6 6 0 Tetratricopeptide repeat PH PF00169.29 CCF47105.1 - 0.0011 19.4 0.0 0.0024 18.3 0.0 1.6 1 0 0 1 1 1 1 PH domain PH_9 PF15410.6 CCF47105.1 - 0.0072 16.7 0.0 0.013 15.8 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain FAM153 PF15722.5 CCF47106.1 - 0.13 12.6 1.1 11 6.4 0.0 2.1 1 1 1 2 2 2 0 FAM153 family MFS_1 PF07690.16 CCF47107.1 - 2.4e-29 102.4 34.1 3.5e-29 101.8 34.1 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 CCF47107.1 - 1.5e-07 30.3 11.4 2.1e-07 29.8 11.4 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) PAN_1 PF00024.26 CCF47108.1 - 4.7e-05 23.3 4.7 5.6e-05 23.0 4.7 1.3 1 0 0 1 1 1 1 PAN domain PAN_4 PF14295.6 CCF47108.1 - 0.43 10.5 6.6 0.089 12.7 1.8 2.1 1 1 1 2 2 2 0 PAN domain Thyroglobulin_1 PF00086.18 CCF47109.1 - 0.04 13.6 0.7 0.071 12.8 0.7 1.4 1 0 0 1 1 1 0 Thyroglobulin type-1 repeat Exo_endo_phos PF03372.23 CCF47111.1 - 0.0013 18.3 0.3 0.002 17.7 0.3 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Pkinase PF00069.25 CCF47112.1 - 1.1e-28 100.3 0.1 4.1e-23 82.1 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCF47112.1 - 3.2e-12 46.3 0.0 1.2e-11 44.4 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase NPL PF17800.1 CCF47113.1 - 1.5e-35 121.9 0.2 1.5e-35 121.9 0.2 2.0 2 1 0 2 2 2 1 Nucleoplasmin-like domain FKBP_C PF00254.28 CCF47113.1 - 8.9e-31 106.1 0.0 6e-30 103.4 0.0 2.3 2 0 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase DJ-1_PfpI PF01965.24 CCF47114.1 - 1.4e-07 31.5 0.0 1.8e-07 31.1 0.0 1.1 1 0 0 1 1 1 1 DJ-1/PfpI family Asparaginase_C PF17763.1 CCF47116.1 - 1.6e-19 70.2 0.0 1.9e-19 69.9 0.0 1.1 1 0 0 1 1 1 1 Glutaminase/Asparaginase C-terminal domain EBP PF05241.12 CCF47117.1 - 5.5e-60 201.9 8.5 6.6e-60 201.6 8.5 1.0 1 0 0 1 1 1 1 Emopamil binding protein Nic96 PF04097.14 CCF47118.1 - 2.4e-72 244.3 0.0 2.7e-72 244.2 0.0 1.0 1 0 0 1 1 1 1 Nup93/Nic96 Peptidase_M48 PF01435.18 CCF47119.1 - 3.7e-12 46.4 0.1 4.2e-12 46.3 0.1 1.1 1 0 0 1 1 1 1 Peptidase family M48 TPR_2 PF07719.17 CCF47121.1 - 9e-12 44.2 7.2 0.00021 21.2 0.0 5.4 5 1 0 5 5 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 CCF47121.1 - 8.4e-11 41.2 3.0 0.0022 17.7 0.0 4.9 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.6 CCF47121.1 - 5.3e-06 26.6 2.0 0.0059 16.9 0.3 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 CCF47121.1 - 7.5e-06 26.5 17.7 0.095 13.4 0.0 5.7 6 0 0 6 6 5 3 Tetratricopeptide repeat TPR_11 PF13414.6 CCF47121.1 - 2.1e-05 24.1 0.4 1.5 8.6 0.1 4.6 6 0 0 6 6 6 2 TPR repeat TPR_4 PF07721.14 CCF47121.1 - 0.00015 22.1 17.7 0.068 13.8 3.1 5.1 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 CCF47121.1 - 0.0013 18.8 1.4 0.78 10.1 0.0 3.9 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 CCF47121.1 - 0.0031 17.8 3.4 50 4.6 0.0 5.8 6 1 0 6 6 5 0 Tetratricopeptide repeat TPR_19 PF14559.6 CCF47121.1 - 0.0099 16.4 3.9 0.22 12.1 0.2 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 CCF47121.1 - 0.11 13.2 1.8 21 6.0 0.1 4.8 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_10 PF13374.6 CCF47121.1 - 0.14 12.1 7.1 16 5.5 0.1 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 CCF47121.1 - 0.34 11.9 19.0 1.1 10.3 0.1 6.6 8 1 0 8 8 6 0 Tetratricopeptide repeat SSF PF00474.17 CCF47122.1 - 2.9e-05 23.1 32.4 0.00049 19.1 32.3 2.2 1 1 0 1 1 1 1 Sodium:solute symporter family DUF5336 PF17270.2 CCF47123.1 - 0.071 12.7 0.3 0.13 11.8 0.1 1.5 2 0 0 2 2 2 0 Family of unknown function (DUF5336) RSN1_TM PF13967.6 CCF47126.1 - 2.8e-38 131.1 3.4 3.3e-38 130.9 3.4 1.0 1 0 0 1 1 1 1 Late exocytosis, associated with Golgi transport PSRP-3_Ycf65 PF04839.13 CCF47129.1 - 0.22 11.8 0.2 0.43 10.8 0.0 1.5 2 0 0 2 2 2 0 Plastid and cyanobacterial ribosomal protein (PSRP-3 / Ycf65) Chorismate_bind PF00425.18 CCF47130.1 - 8.3e-91 304.1 0.0 1e-90 303.8 0.0 1.1 1 0 0 1 1 1 1 chorismate binding enzyme Anth_synt_I_N PF04715.13 CCF47130.1 - 0.00015 22.0 0.1 1.3 9.2 0.0 3.5 3 0 0 3 3 3 2 Anthranilate synthase component I, N terminal region F-box PF00646.33 CCF47134.1 - 5.7e-09 35.6 0.3 1.6e-08 34.3 0.3 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 CCF47134.1 - 9.3e-07 28.6 2.1 2.2e-06 27.5 0.2 2.6 4 0 0 4 4 4 1 F-box-like Zip PF02535.22 CCF47135.1 - 0.94 8.6 14.9 1.8 7.7 14.9 1.5 1 0 0 1 1 1 0 ZIP Zinc transporter CDC45 PF02724.14 CCF47135.1 - 1.1 7.5 15.8 1.7 6.8 15.8 1.2 1 0 0 1 1 1 0 CDC45-like protein eIF-3_zeta PF05091.12 CCF47135.1 - 1.8 7.4 26.9 3 6.7 26.9 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SLC12 PF03522.15 CCF47135.1 - 2.2 7.2 20.6 3.8 6.4 20.6 1.4 1 0 0 1 1 1 0 Solute carrier family 12 Hid1 PF12722.7 CCF47135.1 - 2.2 6.3 18.2 3.2 5.8 18.2 1.4 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SMYLE_N PF18615.1 CCF47135.1 - 3.9 6.9 18.1 9.5 5.7 18.1 1.6 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain GREB1 PF15782.5 CCF47135.1 - 5.8 3.9 24.4 8.8 3.3 24.4 1.3 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer V-ATPase_C PF03223.15 CCF47136.1 - 6.3e-127 424.0 0.2 7.3e-127 423.8 0.2 1.0 1 0 0 1 1 1 1 V-ATPase subunit C APS_kinase PF01583.20 CCF47137.1 - 1.4e-70 236.2 0.0 1.9e-70 235.8 0.0 1.1 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_33 PF13671.6 CCF47137.1 - 1e-05 25.7 0.0 1.8e-05 25.0 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CCF47137.1 - 3.6e-05 24.3 0.0 5.7e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 CCF47137.1 - 0.001 18.6 0.0 0.001 18.6 0.0 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_16 PF13191.6 CCF47137.1 - 0.045 14.1 0.1 0.069 13.5 0.1 1.4 1 1 0 1 1 1 0 AAA ATPase domain PRK PF00485.18 CCF47137.1 - 0.058 13.1 0.0 0.13 12.0 0.0 1.5 1 1 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family DUF463 PF04317.12 CCF47137.1 - 0.14 11.1 0.0 0.16 10.9 0.0 1.2 1 0 0 1 1 1 0 YcjX-like family, DUF463 Trp_DMAT PF11991.8 CCF47138.1 - 2.9e-39 135.5 0.0 3.2e-39 135.4 0.0 1.0 1 0 0 1 1 1 1 Tryptophan dimethylallyltransferase CN_hydrolase PF00795.22 CCF47140.1 - 4.4e-31 108.2 0.0 9.3e-31 107.1 0.0 1.5 1 1 0 1 1 1 1 Carbon-nitrogen hydrolase MFS_1 PF07690.16 CCF47141.1 - 6.9e-11 41.7 19.9 4.9e-08 32.3 19.9 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 CCF47141.1 - 0.015 13.6 0.1 0.015 13.6 0.1 2.1 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Pyridoxal_deC PF00282.19 CCF47142.1 - 2.5e-38 131.8 0.0 3e-38 131.5 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Glyoxalase_4 PF13669.6 CCF47143.1 - 0.049 13.9 0.0 0.073 13.4 0.0 1.2 1 0 0 1 1 1 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Ribosomal_L13e PF01294.18 CCF47143.1 - 0.084 12.7 0.0 0.11 12.4 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein L13e Stn1 PF10451.9 CCF47144.1 - 1.2e-06 27.8 0.0 1.3e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 Telomere regulation protein Stn1 DnaJ PF00226.31 CCF47145.1 - 1.6e-23 82.6 2.2 4.1e-23 81.3 2.2 1.8 1 0 0 1 1 1 1 DnaJ domain Nif11 PF07862.11 CCF47145.1 - 0.0052 17.1 1.6 0.54 10.6 0.0 3.6 3 0 0 3 3 3 1 Nif11 domain DUF493 PF04359.14 CCF47145.1 - 0.076 13.6 0.1 0.27 11.8 0.0 2.0 2 1 1 3 3 3 0 Protein of unknown function (DUF493) Inv-AAD PF18785.1 CCF47146.1 - 1e-58 196.8 0.1 1.2e-58 196.5 0.1 1.0 1 0 0 1 1 1 1 Invertebrate-AID/APOBEC-deaminase dCMP_cyt_deam_1 PF00383.23 CCF47146.1 - 4.3e-13 49.0 0.0 5.5e-13 48.7 0.0 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region APOBEC_N PF08210.11 CCF47146.1 - 0.00054 19.9 0.0 0.0006 19.7 0.0 1.2 1 0 0 1 1 1 1 APOBEC-like N-terminal domain Piwi PF02171.17 CCF47147.1 - 1.9e-70 237.5 0.0 3e-70 236.9 0.0 1.3 1 0 0 1 1 1 1 Piwi domain ArgoN PF16486.5 CCF47147.1 - 1.1e-11 45.5 0.0 2.3e-11 44.5 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoL1 PF08699.10 CCF47147.1 - 1.2e-11 44.1 0.1 2.7e-11 42.9 0.1 1.7 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoL2 PF16488.5 CCF47147.1 - 7.3e-06 26.2 0.0 2e-05 24.8 0.0 1.7 1 0 0 1 1 1 1 Argonaute linker 2 domain ArgoMid PF16487.5 CCF47147.1 - 0.00018 21.7 0.1 0.00048 20.3 0.1 1.8 1 0 0 1 1 1 1 Mid domain of argonaute Glyoxalase PF00903.25 CCF47148.1 - 3.1e-37 127.6 0.2 2.7e-18 66.4 0.0 2.6 2 1 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 CCF47148.1 - 1.9e-15 57.1 0.1 8.8e-07 29.2 0.0 3.5 2 2 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 CCF47148.1 - 1.1e-07 32.1 0.0 0.0085 16.2 0.0 3.3 2 2 0 2 2 2 2 Glyoxalase-like domain Glyoxalase_6 PF18029.1 CCF47148.1 - 2e-06 28.5 0.0 0.012 16.4 0.0 2.9 2 1 1 3 3 3 2 Glyoxalase-like domain Glyoxalase_2 PF12681.7 CCF47148.1 - 7.6e-05 22.6 1.1 1.5 8.8 0.1 4.7 3 2 1 4 4 4 1 Glyoxalase-like domain CppA_N PF14506.6 CCF47148.1 - 0.00069 19.7 0.0 0.36 10.9 0.0 2.5 2 0 0 2 2 2 2 CppA N-terminal DUF1338 PF07063.13 CCF47148.1 - 0.0022 17.3 0.0 0.8 8.8 0.0 3.1 3 1 0 3 3 3 1 Domain of unknown function (DUF1338) MoaF PF10703.9 CCF47148.1 - 0.038 13.9 0.0 1.9 8.5 0.0 2.5 2 0 0 2 2 2 0 MoaF N-terminal domain PRT_C PF08372.10 CCF47148.1 - 0.039 13.7 0.0 7.2 6.3 0.0 2.2 2 0 0 2 2 2 0 Plant phosphoribosyltransferase C-terminal Pfk_N PF18468.1 CCF47148.1 - 0.077 13.4 0.2 0.65 10.4 0.0 2.3 2 0 0 2 2 2 0 Phosphofructokinase N-terminal domain yeast PBD PF00786.28 CCF47150.1 - 0.00029 21.1 1.1 0.0082 16.5 0.3 2.4 2 0 0 2 2 2 2 P21-Rho-binding domain Pirin PF02678.16 CCF47152.1 - 5.4e-29 100.3 0.0 1.2e-28 99.2 0.0 1.6 1 0 0 1 1 1 1 Pirin Pirin_C PF05726.13 CCF47152.1 - 2.9e-24 85.4 0.0 1.2e-23 83.4 0.0 1.9 2 0 0 2 2 2 1 Pirin C-terminal cupin domain Cupin_2 PF07883.11 CCF47152.1 - 1.7e-07 30.9 0.5 5.7e-05 22.8 0.3 2.4 2 0 0 2 2 2 2 Cupin domain Cupin_3 PF05899.12 CCF47152.1 - 0.0052 16.4 0.1 0.038 13.7 0.0 2.3 2 1 0 2 2 2 1 Protein of unknown function (DUF861) Stk19 PF10494.9 CCF47154.1 - 1.6e-82 276.9 0.0 1.9e-82 276.6 0.0 1.0 1 0 0 1 1 1 1 Serine-threonine protein kinase 19 Sugar_tr PF00083.24 CCF47156.1 - 6.1e-33 114.4 12.3 7.2e-33 114.1 12.3 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF47156.1 - 6.4e-11 41.8 18.9 4e-10 39.1 20.3 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_1_like PF12832.7 CCF47156.1 - 7.6 5.3 13.2 13 4.5 13.2 1.4 1 1 0 1 1 1 0 MFS_1 like family ACPS PF01648.20 CCF47158.1 - 2.1e-05 24.6 0.0 2.7e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily Fungal_trans PF04082.18 CCF47160.1 - 0.07 12.2 2.7 0.099 11.7 2.7 1.2 1 0 0 1 1 1 0 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF47162.1 - 9.2e-08 32.1 9.8 1.9e-07 31.1 9.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 CCF47163.1 - 5e-14 51.9 0.0 8.7e-14 51.1 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain MIT PF04212.18 CCF47163.1 - 0.097 12.8 0.1 0.31 11.2 0.0 1.8 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain NAD_synthase PF02540.17 CCF47164.1 - 3.9e-23 81.8 0.0 2.2e-22 79.4 0.0 2.1 1 1 0 1 1 1 1 NAD synthase CN_hydrolase PF00795.22 CCF47164.1 - 2.7e-13 49.9 0.0 4.3e-13 49.2 0.0 1.3 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Methyltransf_23 PF13489.6 CCF47165.1 - 6.6e-22 78.1 0.0 9.6e-22 77.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF47165.1 - 2e-10 40.7 0.0 1.6e-09 37.8 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF47165.1 - 4.9e-10 40.0 0.0 1.1e-09 38.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF47165.1 - 4.5e-07 30.4 0.0 8.1e-07 29.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF47165.1 - 9.2e-07 29.5 0.0 3.2e-06 27.8 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CCF47165.1 - 0.023 14.2 0.0 0.045 13.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_4 PF02390.17 CCF47165.1 - 0.028 13.9 0.0 0.064 12.7 0.0 1.5 1 0 0 1 1 1 0 Putative methyltransferase Met_10 PF02475.16 CCF47165.1 - 0.029 14.1 0.0 0.78 9.5 0.0 2.2 2 0 0 2 2 2 0 Met-10+ like-protein PrmA PF06325.13 CCF47165.1 - 0.073 12.4 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_16 PF10294.9 CCF47165.1 - 0.12 12.1 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase PCMT PF01135.19 CCF47165.1 - 0.2 11.4 0.0 0.98 9.1 0.0 1.9 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_23 PF13489.6 CCF47167.1 - 9e-22 77.7 0.0 1.4e-21 77.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF47167.1 - 6.2e-10 39.7 0.0 1.9e-09 38.1 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF47167.1 - 1.4e-09 37.9 0.0 3.9e-09 36.5 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF47167.1 - 4.2e-08 33.8 0.0 1.4e-07 32.2 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF47167.1 - 2.3e-07 31.4 0.0 7.6e-07 29.7 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCF47167.1 - 0.0046 16.3 0.0 0.78 9.0 0.0 2.6 2 1 1 3 3 3 1 ubiE/COQ5 methyltransferase family FtsJ PF01728.19 CCF47167.1 - 0.0047 17.0 0.0 0.0075 16.4 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_4 PF02390.17 CCF47167.1 - 0.012 15.0 0.0 0.044 13.2 0.0 1.8 2 0 0 2 2 2 0 Putative methyltransferase MTS PF05175.14 CCF47167.1 - 0.049 13.2 0.0 0.1 12.2 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain CMAS PF02353.20 CCF47167.1 - 0.05 12.9 0.0 0.22 10.8 0.0 1.9 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_2 PF00891.18 CCF47167.1 - 0.14 11.4 0.0 0.46 9.7 0.0 1.9 1 1 0 1 1 1 0 O-methyltransferase domain Slu7 PF11708.8 CCF47169.1 - 9.5e-76 255.1 32.4 2.4e-75 253.7 22.6 3.0 2 1 0 2 2 2 1 Pre-mRNA splicing Prp18-interacting factor zf-CCHC_4 PF14392.6 CCF47169.1 - 0.024 14.4 0.4 0.043 13.6 0.4 1.4 1 0 0 1 1 1 0 Zinc knuckle Glyoxalase_6 PF18029.1 CCF47169.1 - 0.062 14.1 0.8 15 6.5 0.1 2.5 2 0 0 2 2 2 0 Glyoxalase-like domain zf-CCHC PF00098.23 CCF47169.1 - 0.093 12.8 2.7 0.18 11.9 2.7 1.4 1 0 0 1 1 1 0 Zinc knuckle RcbX PF02341.15 CCF47169.1 - 0.12 12.6 0.5 0.25 11.6 0.5 1.4 1 0 0 1 1 1 0 RbcX protein DUF3775 PF12616.8 CCF47169.1 - 0.18 11.8 3.1 0.74 9.9 0.2 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3775) CDC27 PF09507.10 CCF47169.1 - 1.5 8.1 29.9 0.81 9.0 4.1 2.3 2 1 0 2 2 2 0 DNA polymerase subunit Cdc27 MRNIP PF15749.5 CCF47169.1 - 8.6 7.1 16.6 1.8 9.4 2.1 3.5 3 0 0 3 3 3 0 MRN-interacting protein Methyltransf_23 PF13489.6 CCF47171.1 - 1.6e-19 70.3 0.0 2.5e-19 69.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF47171.1 - 3.6e-10 40.4 0.0 7.3e-10 39.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF47171.1 - 8.8e-08 32.7 0.0 1.4e-07 32.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF47171.1 - 3.7e-07 30.1 0.0 7.8e-06 25.8 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF47171.1 - 1.6e-06 28.8 0.0 1.1e-05 26.1 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 CCF47171.1 - 0.18 11.6 0.0 0.28 10.9 0.0 1.4 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 CCF47171.1 - 0.19 11.3 0.0 0.3 10.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain CMAS PF02353.20 CCF47171.1 - 0.19 11.0 0.0 0.35 10.1 0.0 1.4 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase FtsJ PF01728.19 CCF47171.1 - 0.2 11.7 0.0 0.4 10.8 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase PAS_3 PF08447.12 CCF47172.1 - 0.03 14.6 0.1 0.042 14.1 0.1 1.2 1 0 0 1 1 1 0 PAS fold DUF3237 PF11578.8 CCF47173.1 - 1.1e-22 80.5 0.2 1.1e-17 64.2 0.1 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF3237) Pectinesterase PF01095.19 CCF47174.1 - 5.4e-08 31.9 5.1 6.9e-08 31.6 5.1 1.1 1 0 0 1 1 1 1 Pectinesterase SAPS PF04499.15 CCF47175.1 - 0.035 12.9 3.0 0.036 12.9 3.0 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein BUD22 PF09073.10 CCF47175.1 - 0.22 10.8 18.1 0.33 10.3 18.1 1.3 1 0 0 1 1 1 0 BUD22 Mpp10 PF04006.12 CCF47175.1 - 0.33 9.3 15.0 0.38 9.2 15.0 1.0 1 0 0 1 1 1 0 Mpp10 protein SDA1 PF05285.12 CCF47175.1 - 2.4 7.5 21.1 3 7.2 21.1 1.1 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 CCF47175.1 - 4.7 5.4 14.2 5.5 5.1 14.2 1.1 1 0 0 1 1 1 0 CDC45-like protein RXT2_N PF08595.11 CCF47175.1 - 8.8 6.3 17.6 2.1 8.4 7.0 2.2 1 1 1 2 2 2 0 RXT2-like, N-terminal Sec62 PF03839.16 CCF47176.1 - 4.1 6.8 4.6 6 6.3 4.6 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 Metallophos_2 PF12850.7 CCF47178.1 - 0.00045 20.4 0.0 0.00046 20.4 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 CCF47178.1 - 0.00062 20.3 0.0 0.00063 20.3 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF3425 PF11905.8 CCF47179.1 - 1.1e-12 48.0 1.4 4e-11 43.0 1.4 2.0 1 1 0 2 2 2 2 Domain of unknown function (DUF3425) CNDH2_M PF16869.5 CCF47180.1 - 0.089 13.5 1.4 11 6.7 0.5 2.2 2 0 0 2 2 2 0 PF16858 DUF3123 PF11321.8 CCF47180.1 - 0.18 12.5 2.5 0.33 11.6 2.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3123) Globin PF00042.22 CCF47182.1 - 0.00093 19.7 0.0 0.072 13.7 0.0 2.2 1 1 0 1 1 1 1 Globin Protoglobin PF11563.8 CCF47182.1 - 0.0089 15.9 0.0 0.013 15.4 0.0 1.2 1 0 0 1 1 1 1 Protoglobin Fungal_trans PF04082.18 CCF47185.1 - 1.4e-07 30.8 0.8 1.6e-06 27.4 0.8 2.0 1 1 0 1 1 1 1 Fungal specific transcription factor domain Pectate_lyase PF03211.13 CCF47186.1 - 4.2e-82 274.6 9.7 6e-82 274.1 9.7 1.2 1 0 0 1 1 1 1 Pectate lyase Aminotran_3 PF00202.21 CCF47189.1 - 1.7e-119 399.1 0.0 1.9e-119 398.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 CCF47189.1 - 0.13 11.4 0.0 0.2 10.8 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class I and II Voltage_CLC PF00654.20 CCF47191.1 - 3.8e-89 299.4 28.7 3.9e-89 299.4 25.7 2.0 2 0 0 2 2 2 1 Voltage gated chloride channel NRDE-2 PF08424.10 CCF47193.1 - 1.2e-97 326.9 3.3 2.3e-97 326.0 1.6 2.2 3 0 0 3 3 3 1 NRDE-2, necessary for RNA interference TPR_14 PF13428.6 CCF47193.1 - 0.17 12.8 11.0 2.2 9.3 0.0 5.9 7 0 0 7 7 7 0 Tetratricopeptide repeat eIF-6 PF01912.18 CCF47194.1 - 7.6e-82 273.5 0.2 9.8e-82 273.1 0.2 1.1 1 0 0 1 1 1 1 eIF-6 family Methyltransf_2 PF00891.18 CCF47196.1 - 0.02 14.2 0.0 0.023 14.0 0.0 1.1 1 0 0 1 1 1 0 O-methyltransferase domain Pribosyltran PF00156.27 CCF47197.1 - 3.5e-07 29.9 0.0 1e-06 28.4 0.0 1.7 1 1 0 1 1 1 1 Phosphoribosyl transferase domain HU-CCDC81_bac_2 PF18175.1 CCF47197.1 - 0.13 12.1 0.1 0.37 10.7 0.1 1.7 2 0 0 2 2 2 0 CCDC81-like prokaryotic HU domain 2 FAD_binding_3 PF01494.19 CCF47198.1 - 4.8e-12 45.8 0.0 5.4e-12 45.6 0.0 1.0 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CCF47198.1 - 7.3e-06 25.4 0.0 3e-05 23.4 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCF47198.1 - 2.2e-05 24.6 0.1 5.2e-05 23.4 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 CCF47198.1 - 6.8e-05 22.1 0.0 0.00073 18.7 0.0 2.1 2 1 0 2 2 2 1 Glucose inhibited division protein A DAO PF01266.24 CCF47198.1 - 0.00042 20.0 0.0 0.00078 19.1 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 CCF47198.1 - 0.00085 18.1 0.0 0.0012 17.7 0.0 1.1 1 0 0 1 1 1 1 HI0933-like protein AlaDh_PNT_C PF01262.21 CCF47198.1 - 0.0017 17.7 0.0 0.0022 17.3 0.0 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.27 CCF47198.1 - 0.0027 18.2 0.0 0.017 15.7 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 CCF47198.1 - 0.0039 17.1 0.0 0.0056 16.6 0.0 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_oxidored PF12831.7 CCF47198.1 - 0.0081 15.6 0.3 0.014 14.8 0.3 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CCF47198.1 - 0.016 14.3 0.1 0.07 12.2 0.0 1.8 2 0 0 2 2 2 0 FAD binding domain Thi4 PF01946.17 CCF47198.1 - 0.16 11.2 0.1 0.28 10.4 0.1 1.3 1 0 0 1 1 1 0 Thi4 family Glu_dehyd_C PF16912.5 CCF47198.1 - 0.19 11.2 0.0 0.36 10.3 0.0 1.5 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus NAD_binding_8 PF13450.6 CCF47199.1 - 0.0025 18.0 2.9 0.0042 17.3 2.9 1.4 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain N2227 PF07942.12 CCF47199.1 - 0.037 13.2 0.0 0.05 12.8 0.0 1.2 1 0 0 1 1 1 0 N2227-like protein Pyr_redox_2 PF07992.14 CCF47199.1 - 0.04 13.1 0.0 0.044 13.0 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase ThiF PF00899.21 CCF47199.1 - 0.17 11.2 0.0 0.25 10.7 0.0 1.2 1 0 0 1 1 1 0 ThiF family AMP-binding_C PF13193.6 CCF47201.1 - 0.0001 23.2 0.0 0.00015 22.7 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain BEN PF10523.9 CCF47203.1 - 0.2 11.9 0.0 0.24 11.7 0.0 1.1 1 0 0 1 1 1 0 BEN domain MFS_1 PF07690.16 CCF47204.1 - 6.1e-10 38.6 16.7 6.1e-10 38.6 16.7 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily HMG_box PF00505.19 CCF47205.1 - 6e-17 61.8 0.1 1.4e-16 60.6 0.1 1.7 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 CCF47205.1 - 3.1e-11 43.7 0.1 3.1e-11 43.7 0.1 1.8 2 0 0 2 2 2 1 HMG-box domain SAM_1 PF00536.30 CCF47205.1 - 2.8e-10 40.5 0.0 4.7e-10 39.7 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 CCF47205.1 - 4.7e-07 29.8 0.0 8.3e-07 29.0 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Pneumo_att_G PF05539.11 CCF47205.1 - 0.099 12.2 5.1 0.18 11.4 5.1 1.4 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G Adeno_E1B_55K_N PF04623.12 CCF47207.1 - 0.099 13.4 3.5 0.19 12.4 3.5 1.4 1 0 0 1 1 1 0 Adenovirus E1B protein N-terminus TPP_enzyme_N PF02776.18 CCF47209.1 - 4.9e-36 123.9 0.2 5.8e-36 123.7 0.2 1.0 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain POR_N PF01855.19 CCF47209.1 - 0.16 11.7 0.1 0.2 11.4 0.1 1.1 1 0 0 1 1 1 0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg AAL_decarboxy PF03306.13 CCF47210.1 - 1.1e-30 106.6 0.0 1.2e-30 106.5 0.0 1.0 1 0 0 1 1 1 1 Alpha-acetolactate decarboxylase DUF3622 PF12286.8 CCF47211.1 - 2.2 8.7 5.8 8.1 6.9 0.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3622) adh_short PF00106.25 CCF47212.1 - 0.00097 18.6 0.1 0.0011 18.5 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase DEAD PF00270.29 CCF47213.1 - 3.3e-49 167.0 0.0 1.4e-48 165.0 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF47213.1 - 4.5e-32 110.7 0.0 1.5e-31 109.0 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCF47213.1 - 0.0017 18.4 0.0 0.0032 17.5 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 CCF47213.1 - 0.017 14.5 0.0 0.031 13.6 0.0 1.3 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit CHCH PF06747.13 CCF47214.1 - 0.0071 16.4 8.3 0.013 15.6 8.3 1.5 1 0 0 1 1 1 1 CHCH domain Phage_B PF02304.15 CCF47214.1 - 0.027 14.9 1.8 0.032 14.6 1.8 1.2 1 0 0 1 1 1 0 Scaffold protein B CX9C PF16860.5 CCF47214.1 - 0.03 14.3 2.4 0.42 10.7 0.5 2.2 2 0 0 2 2 2 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, COX17 PF05051.13 CCF47214.1 - 0.038 14.4 2.3 0.057 13.8 2.3 1.2 1 0 0 1 1 1 0 Cytochrome C oxidase copper chaperone (COX17) Cmc1 PF08583.10 CCF47214.1 - 0.07 13.2 4.1 0.27 11.3 4.1 1.9 1 1 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like DUF2079 PF09852.9 CCF47215.1 - 0.0051 15.7 0.5 0.0065 15.4 0.5 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2079) QueT PF06177.11 CCF47215.1 - 0.012 16.0 2.6 0.015 15.6 2.6 1.2 1 0 0 1 1 1 0 QueT transporter PEP_mutase PF13714.6 CCF47216.1 - 8e-49 166.2 0.3 1e-48 165.9 0.3 1.1 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase ICL PF00463.21 CCF47216.1 - 1.1e-10 40.7 0.1 1.7e-10 40.1 0.1 1.2 1 0 0 1 1 1 1 Isocitrate lyase family Pantoate_transf PF02548.15 CCF47216.1 - 0.0012 18.2 0.1 0.031 13.7 0.0 2.1 2 0 0 2 2 2 1 Ketopantoate hydroxymethyltransferase Fis1_TPR_C PF14853.6 CCF47218.1 - 1.1e-25 89.5 2.3 2e-25 88.6 2.3 1.5 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat Fis1_TPR_N PF14852.6 CCF47218.1 - 8.6e-18 63.7 0.1 1.4e-17 63.0 0.1 1.4 1 0 0 1 1 1 1 Fis1 N-terminal tetratricopeptide repeat TPR_2 PF07719.17 CCF47218.1 - 0.0021 18.0 2.0 0.0038 17.2 2.0 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_6 PF13174.6 CCF47218.1 - 0.077 13.7 0.4 0.18 12.5 0.4 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat FAD_binding_3 PF01494.19 CCF47219.1 - 0.0073 15.6 0.0 0.0098 15.2 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain AP3D1 PF06375.11 CCF47219.1 - 2 8.7 6.5 2.9 8.1 6.5 1.2 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 DUF347 PF03988.12 CCF47221.1 - 0.19 11.9 0.0 0.94 9.7 0.0 1.9 1 1 1 2 2 2 0 Repeat of Unknown Function (DUF347) Ldh_1_N PF00056.23 CCF47222.1 - 2.4e-44 150.8 0.1 3.2e-44 150.4 0.1 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 CCF47222.1 - 7.9e-37 126.8 0.0 1.3e-36 126.1 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain 3Beta_HSD PF01073.19 CCF47222.1 - 0.0031 16.6 0.0 0.004 16.2 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 CCF47222.1 - 0.031 14.2 0.0 0.042 13.7 0.0 1.2 1 0 0 1 1 1 0 NAD(P)H-binding RCR PF12273.8 CCF47224.1 - 8.1e-14 52.3 5.6 1.2e-13 51.7 5.6 1.3 1 0 0 1 1 1 1 Chitin synthesis regulation, resistance to Congo red Tubulin_3 PF14881.6 CCF47225.1 - 8.9e-78 260.1 0.1 1.4e-77 259.5 0.1 1.3 1 0 0 1 1 1 1 Tubulin domain Misat_Tub_SegII PF10644.9 CCF47225.1 - 2.7e-41 140.6 0.0 4.6e-41 139.8 0.0 1.4 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin PF00091.25 CCF47225.1 - 7.8e-09 36.0 0.0 5.3e-05 23.5 0.0 2.5 3 0 0 3 3 3 2 Tubulin/FtsZ family, GTPase domain PAP_central PF04928.17 CCF47226.1 - 5.1e-109 363.0 0.0 7.1e-109 362.5 0.0 1.2 1 0 0 1 1 1 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.15 CCF47226.1 - 8e-69 230.6 0.4 1.5e-68 229.7 0.4 1.5 1 0 0 1 1 1 1 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.23 CCF47226.1 - 2.8e-10 40.4 0.0 6.3e-10 39.2 0.0 1.6 1 1 0 1 1 1 1 Nucleotidyltransferase domain Nrap_D2 PF17403.2 CCF47226.1 - 0.046 13.5 0.1 0.16 11.7 0.1 1.9 2 0 0 2 2 2 0 Nrap protein PAP/OAS-like domain Polbeta PF18765.1 CCF47226.1 - 0.089 12.9 0.0 0.21 11.7 0.0 1.6 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase YtfJ_HI0045 PF09695.10 CCF47228.1 - 0.056 13.1 0.7 0.15 11.7 0.1 2.0 3 0 0 3 3 3 0 Bacterial protein of unknown function (YtfJ_HI0045) Nup160 PF11715.8 CCF47228.1 - 0.067 11.8 0.0 0.6 8.7 0.0 2.0 2 0 0 2 2 2 0 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 CCF47228.1 - 0.1 11.5 0.0 0.97 8.3 0.0 2.2 1 1 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Carn_acyltransf PF00755.20 CCF47229.1 - 0.11 11.1 0.0 0.12 11.0 0.0 1.0 1 0 0 1 1 1 0 Choline/Carnitine o-acyltransferase Homeodomain PF00046.29 CCF47230.1 - 6.2e-13 48.4 3.6 1.2e-12 47.5 3.6 1.5 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 CCF47230.1 - 0.00084 19.2 0.8 0.0023 17.8 0.8 1.7 1 0 0 1 1 1 1 Homeobox KN domain ADIP PF11559.8 CCF47230.1 - 0.18 11.9 8.9 0.39 10.8 8.9 1.6 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF4636 PF15468.6 CCF47230.1 - 0.73 9.5 5.7 0.3 10.8 3.5 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4636) Presenilin PF01080.17 CCF47230.1 - 4.5 5.9 8.0 5.9 5.5 8.0 1.3 1 0 0 1 1 1 0 Presenilin Alpha-amylase PF00128.24 CCF47232.1 - 6.9e-52 177.1 0.6 8.7e-52 176.7 0.6 1.1 1 0 0 1 1 1 1 Alpha amylase, catalytic domain hDGE_amylase PF14701.6 CCF47232.1 - 0.021 13.9 0.0 0.026 13.6 0.0 1.1 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain Vps54_N PF10475.9 CCF47232.1 - 0.18 11.1 0.0 0.22 10.7 0.0 1.1 1 0 0 1 1 1 0 Vacuolar-sorting protein 54, of GARP complex Tim17 PF02466.19 CCF47233.1 - 2.7e-06 27.7 1.9 2.7e-06 27.7 1.9 1.9 1 1 1 2 2 2 1 Tim17/Tim22/Tim23/Pmp24 family NIF PF03031.18 CCF47236.1 - 4.5e-38 130.5 0.0 6.5e-38 130.0 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase NmrA PF05368.13 CCF47237.1 - 5.5e-09 35.9 0.0 7e-09 35.6 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family Hjc PF01870.18 CCF47237.1 - 0.17 11.9 0.0 0.35 10.9 0.0 1.5 1 0 0 1 1 1 0 Archaeal holliday junction resolvase (hjc) CBM_1 PF00734.18 CCF47239.1 - 6.9e-15 54.7 11.7 6.9e-15 54.7 11.7 1.9 2 0 0 2 2 2 1 Fungal cellulose binding domain FtsK_4TM PF13491.6 CCF47240.1 - 0.018 14.8 0.3 0.022 14.5 0.3 1.1 1 0 0 1 1 1 0 4TM region of DNA translocase FtsK/SpoIIIE Corona_S2 PF01601.16 CCF47240.1 - 0.12 10.9 0.7 0.15 10.5 0.7 1.1 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein HemY_N PF07219.13 CCF47240.1 - 1.6 9.0 6.1 0.53 10.5 0.4 2.1 1 1 1 2 2 2 0 HemY protein N-terminus FixP_N PF14715.6 CCF47240.1 - 2.5 7.9 6.5 1.3 8.8 0.5 2.2 2 0 0 2 2 2 0 N-terminal domain of cytochrome oxidase-cbb3, FixP PQ-loop PF04193.14 CCF47240.1 - 4.6 7.1 7.0 3.8 7.4 0.1 2.6 3 0 0 3 3 3 0 PQ loop repeat Ribosomal_L33 PF00471.20 CCF47241.1 - 2.9e-05 24.4 0.0 3.8e-05 24.0 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L33 DUF2371 PF10177.9 CCF47244.1 - 0.046 13.9 0.0 0.06 13.5 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2371) DUF3918 PF13056.6 CCF47244.1 - 0.054 13.1 0.2 0.086 12.5 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3918) MitoNEET_N PF10660.9 CCF47244.1 - 0.076 13.1 0.1 0.16 12.0 0.1 1.5 1 0 0 1 1 1 0 Iron-containing outer mitochondrial membrane protein N-terminus NUC153 PF08159.12 CCF47245.1 - 2.4e-11 43.2 1.8 4.1e-11 42.5 1.8 1.4 1 0 0 1 1 1 1 NUC153 domain BTB_2 PF02214.22 CCF47246.1 - 1e-07 32.2 0.1 0.00041 20.6 0.0 2.2 2 0 0 2 2 2 2 BTB/POZ domain TRAM_LAG1_CLN8 PF03798.16 CCF47247.1 - 4e-40 137.7 14.4 4e-40 137.7 14.4 1.6 2 0 0 2 2 2 1 TLC domain TRAM1 PF08390.11 CCF47247.1 - 3.3e-20 71.5 0.0 3.3e-20 71.5 0.0 2.1 2 0 0 2 2 2 1 TRAM1-like protein Pox_G7 PF05503.12 CCF47248.1 - 0.74 8.7 3.4 0.9 8.4 3.4 1.2 1 0 0 1 1 1 0 Poxvirus G7-like Peptidase_C37 PF05416.12 CCF47248.1 - 2.5 6.5 6.6 2.9 6.3 6.6 1.2 1 0 0 1 1 1 0 Southampton virus-type processing peptidase BAF1_ABF1 PF04684.13 CCF47248.1 - 4.4 6.2 31.1 5.4 6.0 31.1 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor SID-1_RNA_chan PF13965.6 CCF47248.1 - 9 4.6 8.4 12 4.2 8.4 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF3622 PF12286.8 CCF47249.1 - 2.2 8.7 5.8 8.1 6.9 0.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3622) Esterase_phd PF10503.9 CCF47251.1 - 4.4e-13 49.3 0.0 5e-13 49.1 0.0 1.1 1 0 0 1 1 1 1 Esterase PHB depolymerase Peptidase_S9 PF00326.21 CCF47251.1 - 0.00056 19.4 0.4 0.00089 18.8 0.1 1.4 2 0 0 2 2 2 1 Prolyl oligopeptidase family COesterase PF00135.28 CCF47251.1 - 0.0036 16.2 0.0 0.005 15.8 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_2 PF02230.16 CCF47251.1 - 0.0075 16.1 0.0 1.9 8.2 0.0 2.1 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Abhydrolase_3 PF07859.13 CCF47251.1 - 0.025 14.4 0.0 0.031 14.1 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold PHP PF02811.19 CCF47252.1 - 2.8e-09 37.5 0.0 3e-09 37.4 0.0 1.3 1 1 0 1 1 1 1 PHP domain Nup54_57_C PF18570.1 CCF47255.1 - 7.9e-16 57.3 6.1 1e-15 57.0 6.1 1.2 1 0 0 1 1 1 1 NUP57/Nup54 C-terminal domain Adhesin_P1_N PF18652.1 CCF47255.1 - 0.00048 20.1 1.0 0.00063 19.7 1.0 1.2 1 0 0 1 1 1 1 Adhesin P1 N-terminal domain DUF4337 PF14235.6 CCF47255.1 - 0.012 15.7 1.7 0.012 15.7 1.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) AAA_32 PF13654.6 CCF47255.1 - 0.02 13.7 0.6 0.02 13.7 0.6 1.0 1 0 0 1 1 1 0 AAA domain Tup_N PF08581.10 CCF47255.1 - 0.023 15.0 1.3 0.025 14.9 1.3 1.2 1 0 0 1 1 1 0 Tup N-terminal DUF948 PF06103.11 CCF47255.1 - 0.19 12.0 0.1 0.23 11.8 0.1 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Tom5 PF10642.9 CCF47256.1 - 1.3e-22 79.6 0.7 1.4e-22 79.5 0.7 1.0 1 0 0 1 1 1 1 Mitochondrial import receptor subunit or translocase GDC-P PF02347.16 CCF47257.1 - 2.7e-172 573.4 0.0 7.6e-160 532.4 0.0 2.8 1 1 0 2 2 2 2 Glycine cleavage system P-protein Aminotran_5 PF00266.19 CCF47257.1 - 1.7e-09 37.1 0.0 0.0001 21.4 0.0 2.3 2 0 0 2 2 2 2 Aminotransferase class-V Beta_elim_lyase PF01212.21 CCF47257.1 - 0.0002 20.7 0.0 0.00037 19.9 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.20 CCF47257.1 - 0.0072 14.9 0.0 0.015 13.9 0.0 1.4 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Thioredox_DsbH PF03190.15 CCF47258.1 - 2.8e-58 196.5 0.0 4.4e-58 195.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF255 Thioredoxin_7 PF13899.6 CCF47258.1 - 3.3e-05 24.0 0.0 6.8e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like Sigma70_r4 PF04545.16 CCF47258.1 - 0.1 12.1 0.2 0.22 11.0 0.2 1.6 1 0 0 1 1 1 0 Sigma-70, region 4 Neugrin PF06413.11 CCF47260.1 - 1.5e-13 51.3 0.5 2.1e-13 50.8 0.3 1.3 1 1 0 1 1 1 1 Neugrin MRP-L20 PF12824.7 CCF47260.1 - 7.7e-08 32.7 0.1 7.7e-08 32.7 0.1 1.9 2 0 0 2 2 2 1 Mitochondrial ribosomal protein subunit L20 Sigma70_r4 PF04545.16 CCF47260.1 - 0.009 15.5 0.1 0.059 12.9 0.0 2.2 2 0 0 2 2 2 1 Sigma-70, region 4 Skp1 PF01466.19 CCF47260.1 - 0.02 15.0 0.1 0.05 13.7 0.1 1.7 1 0 0 1 1 1 0 Skp1 family, dimerisation domain MazG-like PF12643.7 CCF47260.1 - 0.023 14.9 0.0 0.055 13.7 0.0 1.6 1 0 0 1 1 1 0 MazG-like family DUF5642 PF18702.1 CCF47260.1 - 0.25 11.1 0.0 0.37 10.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5642) DUF4746 PF15928.5 CCF47260.1 - 0.58 9.5 3.5 0.36 10.2 1.4 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4746) IBN_N PF03810.19 CCF47261.1 - 1.4e-05 24.9 0.0 1.8e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 Importin-beta N-terminal domain HEAT_2 PF13646.6 CCF47261.1 - 0.00053 20.3 0.2 0.0006 20.1 0.2 1.1 1 0 0 1 1 1 1 HEAT repeats Nipped-B_C PF12830.7 CCF47261.1 - 0.11 12.4 0.0 0.12 12.3 0.0 1.1 1 0 0 1 1 1 0 Sister chromatid cohesion C-terminus TIM PF00121.18 CCF47262.1 - 0.078 12.3 0.0 0.089 12.1 0.0 1.0 1 0 0 1 1 1 0 Triosephosphate isomerase Toxin_7 PF05980.12 CCF47263.1 - 0.007 16.6 1.8 0.016 15.5 1.8 1.6 1 0 0 1 1 1 1 Toxin 7 Tachystatin_A PF11406.8 CCF47263.1 - 0.011 15.8 4.0 0.013 15.6 4.0 1.3 1 0 0 1 1 1 0 Antimicrobial peptide tachystatin A DUF3712 PF12505.8 CCF47264.1 - 5.1e-09 36.4 0.1 2e-06 28.1 0.2 2.8 2 0 0 2 2 2 2 Protein of unknown function (DUF3712) OTCace_N PF02729.21 CCF47265.1 - 1.3e-43 148.6 0.0 1.8e-43 148.1 0.0 1.2 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain OTCace PF00185.24 CCF47265.1 - 5.7e-43 146.7 0.0 1e-42 145.9 0.0 1.4 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain Glyco_hydro_4 PF02056.16 CCF47265.1 - 0.12 11.9 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 Family 4 glycosyl hydrolase ALS_ss_C PF10369.9 CCF47266.1 - 2.4e-15 56.5 0.0 2.3e-14 53.3 0.0 2.4 2 0 0 2 2 2 1 Small subunit of acetolactate synthase ACT PF01842.25 CCF47266.1 - 6.4e-15 54.6 0.1 1.3e-14 53.6 0.1 1.6 1 0 0 1 1 1 1 ACT domain ACT_5 PF13710.6 CCF47266.1 - 1.3e-08 34.5 0.1 2.9e-08 33.4 0.0 1.6 2 0 0 2 2 2 1 ACT domain ACT_6 PF13740.6 CCF47266.1 - 0.097 12.7 0.0 26 4.9 0.0 2.7 2 0 0 2 2 2 0 ACT domain KH_1 PF00013.29 CCF47267.1 - 4.4e-07 29.6 0.1 0.00031 20.5 0.0 2.7 2 1 0 2 2 2 2 KH domain Trp_repressor PF01371.19 CCF47267.1 - 0.14 12.3 0.1 1.7 8.9 0.0 2.3 2 0 0 2 2 2 0 Trp repressor protein FA_desaturase PF00487.24 CCF47268.1 - 6.6e-22 78.6 18.0 8.1e-22 78.3 18.0 1.1 1 0 0 1 1 1 1 Fatty acid desaturase PGI PF00342.19 CCF47269.1 - 2.6e-130 435.3 1.4 3e-130 435.1 1.4 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase Methyltransf_11 PF08241.12 CCF47271.1 - 1.1e-16 61.3 0.0 2.1e-16 60.3 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF47271.1 - 4.5e-15 56.1 0.1 4.5e-14 52.9 0.1 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF47271.1 - 6.4e-14 52.1 0.0 9.8e-14 51.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 CCF47271.1 - 7e-14 51.8 0.2 4.8e-12 45.7 0.1 2.2 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.12 CCF47271.1 - 9.9e-14 51.9 0.0 1.8e-13 51.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF47271.1 - 1e-11 44.8 0.0 2.9e-10 40.1 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCF47271.1 - 4.4e-06 26.2 0.0 1.1e-05 24.9 0.0 1.6 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family MetW PF07021.12 CCF47271.1 - 0.00025 20.7 0.0 0.0049 16.5 0.2 2.1 1 1 1 2 2 2 1 Methionine biosynthesis protein MetW DOT1 PF08123.13 CCF47271.1 - 0.0015 18.1 0.0 0.0023 17.5 0.0 1.2 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_32 PF13679.6 CCF47271.1 - 0.0057 16.7 0.1 0.0084 16.1 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 CCF47271.1 - 0.0061 16.3 0.0 0.0093 15.7 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 CCF47271.1 - 0.014 14.9 0.3 0.031 13.8 0.1 1.6 2 0 0 2 2 2 0 Methyltransferase small domain TehB PF03848.14 CCF47271.1 - 0.023 14.1 0.1 0.036 13.5 0.1 1.3 1 0 0 1 1 1 0 Tellurite resistance protein TehB Methyltransf_PK PF05891.12 CCF47271.1 - 0.06 12.8 0.0 0.46 10.0 0.0 2.0 1 1 0 1 1 1 0 AdoMet dependent proline di-methyltransferase RrnaAD PF00398.20 CCF47271.1 - 0.14 11.2 0.1 0.2 10.7 0.1 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase NodS PF05401.11 CCF47271.1 - 0.2 11.3 0.0 0.28 10.8 0.0 1.2 1 0 0 1 1 1 0 Nodulation protein S (NodS) Proteasome PF00227.26 CCF47272.1 - 2.7e-29 102.0 0.0 3.2e-29 101.8 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit p450 PF00067.22 CCF47273.1 - 1.8e-60 205.0 0.0 2.4e-60 204.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 FAD_binding_3 PF01494.19 CCF47275.1 - 1.9e-16 60.3 3.9 3.4e-16 59.4 1.6 2.4 1 1 1 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.6 CCF47275.1 - 7.1e-08 32.6 0.1 1.6e-07 31.4 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CCF47275.1 - 8.7e-07 28.4 0.4 8.9e-05 21.9 0.6 2.2 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CCF47275.1 - 1.4e-05 24.4 1.5 0.00022 20.4 1.5 2.2 2 0 0 2 2 2 1 FAD binding domain DAO PF01266.24 CCF47275.1 - 2.6e-05 24.0 1.7 2.6e-05 24.0 1.7 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 CCF47275.1 - 0.00016 21.0 0.1 0.00027 20.3 0.1 1.3 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.14 CCF47275.1 - 0.00039 19.3 0.0 0.00062 18.6 0.0 1.4 1 0 0 1 1 1 1 HI0933-like protein AlaDh_PNT_C PF01262.21 CCF47275.1 - 0.00097 18.5 0.1 0.0017 17.7 0.1 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_3 PF13738.6 CCF47275.1 - 0.0038 16.5 0.9 0.46 9.7 0.7 2.3 1 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CCF47275.1 - 0.012 14.8 0.2 0.017 14.2 0.2 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A Pyr_redox PF00070.27 CCF47275.1 - 0.024 15.2 0.1 0.071 13.7 0.1 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 CCF47275.1 - 0.029 13.4 3.2 0.37 9.8 0.4 2.8 3 0 0 3 3 3 0 Lycopene cyclase protein NAD_binding_9 PF13454.6 CCF47275.1 - 0.041 13.9 0.3 0.19 11.7 0.3 2.4 1 1 0 1 1 1 0 FAD-NAD(P)-binding Amino_oxidase PF01593.24 CCF47275.1 - 0.045 13.0 0.1 8.9 5.5 0.0 2.8 3 0 0 3 3 3 0 Flavin containing amine oxidoreductase 3HCDH_N PF02737.18 CCF47275.1 - 0.29 11.0 1.5 0.32 10.8 0.1 1.7 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Spt20 PF12090.8 CCF47276.1 - 0.22 11.1 41.0 0.29 10.7 21.5 2.1 2 0 0 2 2 2 0 Spt20 family NST1 PF13945.6 CCF47276.1 - 0.4 10.8 16.5 0.25 11.4 8.4 2.2 2 0 0 2 2 2 0 Salt tolerance down-regulator FAM76 PF16046.5 CCF47276.1 - 1.5 8.1 12.4 2.7 7.3 5.0 2.0 2 0 0 2 2 2 0 FAM76 protein DUF702 PF05142.12 CCF47276.1 - 2.2 8.7 16.0 3.7 8.0 9.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF702) RLL PF10036.9 CCF47276.1 - 6.7 6.5 13.5 8.5 6.1 1.8 2.2 2 0 0 2 2 2 0 RNA transcription, translation and transport factor protein Fibrillarin PF01269.17 CCF47277.1 - 3.2e-47 160.5 0.1 3.6e-47 160.4 0.1 1.0 1 0 0 1 1 1 1 Fibrillarin SBDS PF01172.18 CCF47281.1 - 5e-25 87.4 1.1 6e-25 87.2 1.1 1.1 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein DUF4827 PF16109.5 CCF47281.1 - 0.065 13.2 0.2 0.083 12.9 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4827) Tubulin PF00091.25 CCF47283.1 - 0.52 10.5 4.6 1 9.5 0.7 2.0 1 1 0 2 2 2 0 Tubulin/FtsZ family, GTPase domain MFS_1 PF07690.16 CCF47284.1 - 4.6e-36 124.5 21.1 2.2e-28 99.2 15.6 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF47284.1 - 3.1e-08 32.9 4.2 3.1e-08 32.9 4.2 2.3 2 0 0 2 2 2 2 Sugar (and other) transporter BT1 PF03092.16 CCF47284.1 - 0.88 7.7 6.9 4.8 5.3 1.8 2.2 2 0 0 2 2 2 0 BT1 family Inositol_P PF00459.25 CCF47285.1 - 5.9e-20 71.9 3.1 6.6e-20 71.8 3.1 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family Gamma-thionin PF00304.20 CCF47285.1 - 0.087 13.1 0.2 0.12 12.6 0.2 1.2 1 0 0 1 1 1 0 Gamma-thionin family fn3_5 PF06280.12 CCF47286.1 - 2.1e-06 28.4 0.1 7.6e-06 26.6 0.1 1.8 1 1 0 1 1 1 1 Fn3-like domain DUF4232 PF14016.6 CCF47286.1 - 0.025 14.7 0.0 0.65 10.1 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4232) Pam16 PF03656.13 CCF47286.1 - 0.029 14.4 0.0 0.039 14.0 0.0 1.1 1 0 0 1 1 1 0 Pam16 fn3_6 PF17766.1 CCF47286.1 - 0.088 13.0 0.2 0.57 10.4 0.1 2.3 1 1 0 1 1 1 0 Fibronectin type-III domain ELO PF01151.18 CCF47287.1 - 5.2e-55 186.7 9.5 6.3e-55 186.4 9.5 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family CSN5_C PF18323.1 CCF47288.1 - 1.2e-12 48.5 0.1 1.5e-12 48.3 0.1 1.1 1 0 0 1 1 1 1 Cop9 signalosome subunit 5 C-terminal domain PFK PF00365.20 CCF47291.1 - 1.9e-163 542.6 0.5 8e-106 353.5 1.0 2.1 2 0 0 2 2 2 2 Phosphofructokinase UVR PF02151.19 CCF47291.1 - 0.0058 16.3 0.4 0.013 15.2 0.4 1.6 1 0 0 1 1 1 1 UvrB/uvrC motif DUF211 PF02680.14 CCF47291.1 - 0.084 13.0 0.0 0.21 11.8 0.0 1.7 1 0 0 1 1 1 0 Uncharacterized ArCR, COG1888 Med17 PF10156.9 CCF47292.1 - 6.2e-86 288.9 0.0 7.8e-86 288.6 0.0 1.0 1 0 0 1 1 1 1 Subunit 17 of Mediator complex DUF1382 PF07131.11 CCF47292.1 - 0.12 12.4 0.4 3.8 7.6 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1382) Helicase_C PF00271.31 CCF47293.1 - 2.2e-15 57.0 0.0 7e-15 55.3 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 CCF47293.1 - 4.3e-15 55.3 0.1 7.9e-15 54.4 0.1 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain zf-RING_UBOX PF13445.6 CCF47293.1 - 2.3e-08 33.9 2.5 2.7e-08 33.7 1.1 1.9 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 CCF47293.1 - 3.9e-08 33.0 5.1 8.2e-08 32.0 5.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CCF47293.1 - 2.5e-07 30.4 2.3 2.5e-07 30.4 2.3 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CCF47293.1 - 5.5e-06 26.6 4.3 5.5e-06 26.6 4.3 2.0 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 CCF47293.1 - 1.2e-05 25.0 4.5 3.6e-05 23.5 4.5 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 CCF47293.1 - 4.7e-05 23.5 4.8 0.00011 22.3 4.8 1.7 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 CCF47293.1 - 0.00015 21.7 4.0 0.00034 20.5 4.0 1.7 1 0 0 1 1 1 1 zinc-RING finger domain ERCC3_RAD25_C PF16203.5 CCF47293.1 - 0.013 14.7 0.0 0.026 13.8 0.0 1.4 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase zf-WRNIP1_ubi PF18279.1 CCF47293.1 - 0.048 14.3 3.1 1 10.1 0.5 2.5 2 0 0 2 2 2 0 Werner helicase-interacting protein 1 ubiquitin-binding domain zf-RING_4 PF14570.6 CCF47293.1 - 1.9 8.3 5.2 8.3 6.3 5.4 2.1 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_10 PF16685.5 CCF47293.1 - 4.8 7.4 7.1 0.49 10.6 2.3 1.9 2 0 0 2 2 1 0 zinc RING finger of MSL2 Prok-RING_4 PF14447.6 CCF47293.1 - 8.8 6.3 8.9 1.2e+02 2.7 9.5 2.4 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 Pkinase PF00069.25 CCF47294.1 - 6.6e-75 251.9 0.0 1.8e-35 122.6 0.0 3.8 3 1 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 CCF47294.1 - 2e-49 168.2 0.0 3.4e-21 75.7 0.0 3.3 3 0 0 3 3 3 3 Protein tyrosine kinase RWD PF05773.22 CCF47294.1 - 3e-11 43.6 0.0 1e-10 41.9 0.0 2.0 1 0 0 1 1 1 1 RWD domain tRNA-synt_His PF13393.6 CCF47294.1 - 1.1e-08 34.8 1.3 1.6e-08 34.2 0.0 1.9 2 0 0 2 2 2 1 Histidyl-tRNA synthetase APH PF01636.23 CCF47294.1 - 1.8e-06 28.1 3.7 0.02 14.8 0.2 3.0 3 0 0 3 3 3 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CCF47294.1 - 2.2e-06 26.8 1.6 0.034 12.9 0.1 3.0 3 0 0 3 3 3 2 Fungal protein kinase Kinase-like PF14531.6 CCF47294.1 - 6.7e-05 22.3 0.0 0.0026 17.1 0.0 2.7 2 0 0 2 2 2 1 Kinase-like YrbL-PhoP_reg PF10707.9 CCF47294.1 - 0.0087 15.6 0.0 0.76 9.3 0.0 2.5 2 0 0 2 2 2 1 PhoP regulatory network protein YrbL Med21 PF11221.8 CCF47294.1 - 0.013 15.7 2.6 0.046 14.0 2.6 1.9 1 0 0 1 1 1 0 Subunit 21 of Mediator complex CDC45 PF02724.14 CCF47294.1 - 1.4 7.1 11.8 0.41 8.9 3.4 2.1 2 0 0 2 2 2 0 CDC45-like protein Sporozoite_P67 PF05642.11 CCF47294.1 - 3.6 5.5 7.7 5.4 5.0 5.4 2.0 2 0 0 2 2 2 0 Sporozoite P67 surface antigen Cut12 PF11500.8 CCF47295.1 - 8.4e-49 165.2 19.1 8.4e-49 165.2 19.1 4.0 2 1 1 4 4 4 1 Spindle pole body formation-associated protein TSC22 PF01166.18 CCF47295.1 - 0.86 10.0 6.2 2.1 8.7 2.2 3.1 2 0 0 2 2 2 0 TSC-22/dip/bun family Fez1 PF06818.15 CCF47295.1 - 3.3 8.1 61.3 2.7 8.4 23.7 3.5 1 1 2 3 3 3 0 Fez1 IGPD PF00475.18 CCF47296.1 - 8.9e-60 201.2 0.2 1.2e-59 200.7 0.2 1.2 1 0 0 1 1 1 1 Imidazoleglycerol-phosphate dehydratase ArgJ PF01960.18 CCF47297.1 - 1.6e-148 494.5 0.2 1.8e-148 494.3 0.2 1.0 1 0 0 1 1 1 1 ArgJ family DER1 PF04511.15 CCF47298.1 - 5.9e-26 91.6 9.5 6.8e-26 91.4 9.5 1.0 1 0 0 1 1 1 1 Der1-like family DUF3273 PF11677.8 CCF47298.1 - 1.1 8.6 6.9 2.4 7.4 6.9 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3273) DUF5090 PF17009.5 CCF47298.1 - 1.3 8.9 3.5 3.2 7.7 3.5 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF5090) DUF3499 PF12005.8 CCF47299.1 - 0.0068 17.0 0.0 0.015 15.9 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3499) EphA2_TM PF14575.6 CCF47299.1 - 0.061 14.2 0.0 0.22 12.5 0.0 2.0 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF3481 PF11980.8 CCF47299.1 - 0.096 12.4 0.8 0.96 9.2 0.2 2.4 2 0 0 2 2 2 0 C-terminal domain of neuropilin glycoprotein COX14 PF14880.6 CCF47299.1 - 0.21 11.5 0.2 0.47 10.3 0.2 1.5 1 0 0 1 1 1 0 Cytochrome oxidase c assembly SPC12 PF06645.13 CCF47302.1 - 7.7e-31 106.0 0.2 9e-31 105.8 0.2 1.1 1 0 0 1 1 1 1 Microsomal signal peptidase 12 kDa subunit (SPC12) zf-rbx1 PF12678.7 CCF47303.1 - 6.8e-25 87.1 12.9 9.7e-25 86.6 12.9 1.2 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 CCF47303.1 - 4.7e-17 61.8 9.8 6.1e-17 61.5 9.8 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 CCF47303.1 - 3.9e-06 27.1 14.1 0.00014 22.1 14.1 2.2 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 CCF47303.1 - 5.2e-05 23.0 3.1 5.2e-05 23.0 3.1 2.3 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CCF47303.1 - 0.0016 18.3 11.5 0.028 14.3 11.5 2.4 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CCF47303.1 - 0.2 11.6 10.7 0.6 10.0 4.5 2.6 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 CCF47303.1 - 0.33 10.7 15.9 29 4.5 15.9 2.5 1 1 0 1 1 1 0 RING-like zinc finger zf-RING_UBOX PF13445.6 CCF47303.1 - 0.4 10.7 6.8 1.5 9.0 6.8 2.0 1 1 0 1 1 1 0 RING-type zinc-finger FANCL_C PF11793.8 CCF47303.1 - 1 9.6 9.4 5.9 7.2 9.6 2.0 1 1 1 2 2 2 0 FANCL C-terminal domain Zn_ribbon_17 PF17120.5 CCF47303.1 - 1.4 8.6 15.0 0.32 10.6 4.9 2.3 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type zf-RING_5 PF14634.6 CCF47303.1 - 6.3 6.8 12.2 55 3.8 12.2 2.5 1 1 0 1 1 1 0 zinc-RING finger domain DUF3328 PF11807.8 CCF47305.1 - 6.4e-05 22.8 0.0 8.8e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) G-alpha PF00503.20 CCF47307.1 - 3.6e-107 358.6 1.7 4.1e-107 358.4 1.7 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 CCF47307.1 - 9.2e-11 41.5 0.2 2.3e-10 40.2 0.2 1.6 1 1 0 1 1 1 1 ADP-ribosylation factor family zf-CHC2 PF01807.20 CCF47307.1 - 6e-05 22.8 0.0 0.00027 20.7 0.0 1.9 2 0 0 2 2 2 1 CHC2 zinc finger p450 PF00067.22 CCF47308.1 - 2.7e-08 33.0 0.0 3.6e-08 32.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 DNA_pol_phi PF04931.13 CCF47310.1 - 0.069 11.3 0.6 0.076 11.1 0.6 1.0 1 0 0 1 1 1 0 DNA polymerase phi Pox_Ag35 PF03286.14 CCF47310.1 - 3.1 7.6 6.9 0.14 11.9 1.8 1.4 2 0 0 2 2 2 0 Pox virus Ag35 surface protein FAM176 PF14851.6 CCF47310.1 - 3.7 7.2 7.5 4.5 6.9 7.2 1.3 1 1 0 1 1 1 0 FAM176 family CBF PF03914.17 CCF47311.1 - 1.3e-35 122.9 0.6 2.2e-35 122.2 0.2 1.5 1 1 1 2 2 2 1 CBF/Mak21 family CorA PF01544.18 CCF47312.1 - 3.9e-41 141.3 0.2 1.2e-40 139.7 0.2 1.7 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein Osmo_CC PF08946.10 CCF47312.1 - 0.027 14.7 0.3 0.064 13.5 0.3 1.6 1 0 0 1 1 1 0 Osmosensory transporter coiled coil DUF896 PF05979.12 CCF47313.1 - 0.18 11.7 3.1 0.24 11.3 0.6 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF896) STPPase_N PF16891.5 CCF47314.1 - 1e-24 86.7 1.0 1.1e-24 86.5 1.0 1.0 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain NRBF2 PF08961.10 CCF47315.1 - 0.00027 20.6 1.2 0.00035 20.3 1.2 1.3 1 0 0 1 1 1 1 Nuclear receptor-binding factor 2, autophagy regulator ADIP PF11559.8 CCF47315.1 - 0.0063 16.6 2.6 0.0074 16.4 2.6 1.1 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding bZIP_1 PF00170.21 CCF47315.1 - 0.0066 16.5 1.4 0.0066 16.5 1.4 1.5 2 0 0 2 2 1 1 bZIP transcription factor Leu_zip PF15294.6 CCF47315.1 - 0.007 15.9 0.2 0.007 15.9 0.2 1.1 1 0 0 1 1 1 1 Leucine zipper Rootletin PF15035.6 CCF47315.1 - 0.0079 16.2 1.7 0.01 15.9 1.7 1.2 1 0 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion ZapB PF06005.12 CCF47315.1 - 0.012 16.1 8.4 0.029 14.8 8.1 1.7 1 1 0 1 1 1 0 Cell division protein ZapB HALZ PF02183.18 CCF47315.1 - 0.016 15.4 1.9 0.036 14.3 1.9 1.7 1 0 0 1 1 1 0 Homeobox associated leucine zipper PIN_9 PF18477.1 CCF47315.1 - 0.016 15.5 0.4 0.023 15.0 0.4 1.2 1 0 0 1 1 1 0 PIN like domain DivIC PF04977.15 CCF47315.1 - 0.018 14.8 2.6 0.018 14.8 2.6 2.0 1 1 1 2 2 2 0 Septum formation initiator JIP_LZII PF16471.5 CCF47315.1 - 0.02 15.0 5.1 0.022 14.9 4.3 1.5 1 1 1 2 2 2 0 JNK-interacting protein leucine zipper II Fez1 PF06818.15 CCF47315.1 - 0.034 14.6 0.9 0.035 14.6 0.9 1.1 1 0 0 1 1 1 0 Fez1 Spc7 PF08317.11 CCF47315.1 - 0.039 12.8 2.2 0.051 12.4 2.2 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein ATG16 PF08614.11 CCF47315.1 - 0.12 12.6 6.8 0.15 12.3 6.8 1.1 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF3450 PF11932.8 CCF47315.1 - 0.13 11.5 4.4 0.17 11.2 4.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) phiKZ_IP PF12699.7 CCF47315.1 - 0.14 11.3 0.0 0.16 11.0 0.0 1.1 1 0 0 1 1 1 0 phiKZ-like phage internal head proteins YabA PF06156.13 CCF47315.1 - 0.14 12.8 0.6 0.19 12.4 0.6 1.2 1 0 0 1 1 1 0 Initiation control protein YabA Prominin PF05478.11 CCF47315.1 - 0.14 10.1 0.2 0.18 9.8 0.2 1.0 1 0 0 1 1 1 0 Prominin WXG100 PF06013.12 CCF47315.1 - 0.17 12.1 1.6 0.23 11.7 0.2 1.8 2 0 0 2 2 2 0 Proteins of 100 residues with WXG TolA_bind_tri PF16331.5 CCF47315.1 - 0.19 11.8 7.2 0.51 10.5 7.2 1.7 1 1 0 1 1 1 0 TolA binding protein trimerisation CENP-F_leu_zip PF10473.9 CCF47315.1 - 0.2 11.7 6.0 0.43 10.6 6.0 1.5 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Atg14 PF10186.9 CCF47315.1 - 0.78 8.8 2.1 0.92 8.5 2.1 1.0 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 FUSC PF04632.12 CCF47315.1 - 1.8 7.0 6.0 1.9 6.9 6.0 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family TMF_DNA_bd PF12329.8 CCF47315.1 - 2.1 8.4 6.4 3.2 7.8 6.4 1.3 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding Surfac_D-trimer PF09006.11 CCF47315.1 - 3.2 7.7 4.4 0.74 9.8 0.3 2.1 3 0 0 3 3 3 0 Lung surfactant protein D coiled-coil trimerisation zf-H2C2_2 PF13465.6 CCF47316.1 - 3.4e-08 33.6 25.7 4.2e-07 30.1 0.3 5.5 5 1 0 5 5 5 3 Zinc-finger double domain zf-C2H2 PF00096.26 CCF47316.1 - 6.4e-06 26.3 26.3 8.3e-05 22.8 2.0 4.6 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCF47316.1 - 0.00025 21.6 8.5 0.01 16.6 1.3 4.3 4 2 0 4 4 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CCF47316.1 - 0.0022 18.2 7.2 0.006 16.8 1.1 3.2 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 CCF47316.1 - 0.0027 17.7 13.6 0.0098 15.9 1.0 3.0 3 0 0 3 3 3 2 C2H2-type zinc finger zf-met PF12874.7 CCF47316.1 - 0.0043 17.4 7.4 0.0061 16.9 0.7 3.0 3 0 0 3 3 3 1 Zinc-finger of C2H2 type HypA PF01155.19 CCF47316.1 - 0.031 14.3 0.4 0.053 13.5 0.4 1.3 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Zn-ribbon_8 PF09723.10 CCF47316.1 - 0.066 13.4 1.7 0.066 13.4 1.7 2.9 2 2 1 3 3 3 0 Zinc ribbon domain zf-C2H2_3rep PF18868.1 CCF47316.1 - 0.072 13.8 2.8 0.11 13.1 2.6 1.5 1 1 0 1 1 1 0 Zinc finger C2H2-type, 3 repeats zf-C2HE PF16278.5 CCF47316.1 - 0.097 13.1 5.6 0.31 11.5 1.0 2.6 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zinc_ribbon_12 PF11331.8 CCF47316.1 - 0.12 12.1 0.8 0.51 10.2 0.0 2.1 2 0 0 2 2 2 0 Probable zinc-ribbon domain zinc-ribbons_6 PF07191.12 CCF47316.1 - 0.26 11.3 2.8 4.3 7.4 2.8 2.3 1 1 0 1 1 1 0 zinc-ribbons CDO_I PF05995.12 CCF47321.1 - 1.8e-08 33.9 0.0 2e-08 33.7 0.0 1.1 1 0 0 1 1 1 1 Cysteine dioxygenase type I SLAC1 PF03595.17 CCF47322.1 - 1.6e-57 195.2 32.5 1.9e-57 195.0 32.5 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel Wyosine_form PF08608.12 CCF47323.1 - 2e-25 88.9 0.0 5.1e-25 87.6 0.0 1.8 1 0 0 1 1 1 1 Wyosine base formation Radical_SAM PF04055.21 CCF47323.1 - 2.4e-22 80.1 0.0 1.2e-21 77.8 0.0 2.2 2 1 0 2 2 2 1 Radical SAM superfamily Flavodoxin_1 PF00258.25 CCF47323.1 - 1.3e-11 44.9 0.1 5.1e-10 39.7 0.1 3.0 2 1 0 2 2 2 1 Flavodoxin MAS20 PF02064.15 CCF47324.1 - 7.6e-40 136.0 2.7 9.1e-40 135.7 2.7 1.0 1 0 0 1 1 1 1 MAS20 protein import receptor AP-5_subunit_s1 PF15001.6 CCF47324.1 - 0.0027 17.7 2.5 0.0034 17.4 2.5 1.1 1 0 0 1 1 1 1 AP-5 complex subunit sigma-1 CSRNP_N PF16019.5 CCF47324.1 - 0.014 15.4 1.6 0.017 15.0 1.6 1.1 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus DUF533 PF04391.12 CCF47324.1 - 0.026 14.1 2.3 0.033 13.8 2.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF533) Exo84_C PF16528.5 CCF47325.1 - 6.9e-47 159.9 0.1 6.9e-47 159.9 0.1 2.6 3 1 1 4 4 4 1 Exocyst component 84 C-terminal Vps51 PF08700.11 CCF47325.1 - 4.2e-15 55.6 1.9 4.2e-15 55.6 1.9 2.3 3 0 0 3 3 3 1 Vps51/Vps67 COG2 PF06148.11 CCF47325.1 - 0.024 14.7 3.6 0.041 14.0 0.1 2.3 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF3010 PF11215.8 CCF47325.1 - 0.051 13.9 0.2 0.19 12.0 0.2 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3010) Sec5 PF15469.6 CCF47325.1 - 2 8.2 8.2 3.4 7.4 2.4 2.8 3 1 0 3 3 3 0 Exocyst complex component Sec5 DUF4407 PF14362.6 CCF47325.1 - 2.7 7.2 11.2 41 3.4 11.2 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Prominin PF05478.11 CCF47325.1 - 2.8 5.8 10.7 0.33 8.8 3.9 2.2 2 0 0 2 2 2 0 Prominin APG6_N PF17675.1 CCF47325.1 - 3.8 8.1 13.8 7.7 7.1 2.3 2.3 2 0 0 2 2 2 0 Apg6 coiled-coil region SnoaL PF07366.12 CCF47330.1 - 1e-18 67.3 0.0 1.2e-18 67.1 0.0 1.0 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase SnoaL_2 PF12680.7 CCF47330.1 - 9e-08 32.7 0.0 1.3e-07 32.2 0.0 1.2 1 0 0 1 1 1 1 SnoaL-like domain Fungal_trans PF04082.18 CCF47331.1 - 6.1e-16 58.2 0.0 8.5e-16 57.8 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF47331.1 - 1e-10 41.5 10.2 1.9e-10 40.7 10.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 CCF47332.1 - 5.2e-28 98.0 26.0 5.2e-28 98.0 26.0 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Xpo1 PF08389.12 CCF47336.1 - 3.9e-42 143.8 5.9 1.1e-41 142.4 5.9 1.8 1 0 0 1 1 1 1 Exportin 1-like protein CRM1_repeat_2 PF18784.1 CCF47336.1 - 7.9e-34 115.1 3.6 3e-33 113.3 3.6 2.1 1 0 0 1 1 1 1 CRM1 / Exportin repeat 2 CRM1_repeat PF18777.1 CCF47336.1 - 5.5e-18 64.2 0.8 1.4e-17 62.9 0.8 1.8 1 0 0 1 1 1 1 Chromosome region maintenance or exportin repeat HD_assoc PF13286.6 CCF47336.1 - 0.0071 16.9 0.1 7 7.3 0.0 2.5 2 0 0 2 2 2 2 Phosphohydrolase-associated domain Mem_trans PF03547.18 CCF47336.1 - 0.053 11.9 0.0 0.078 11.4 0.0 1.2 1 0 0 1 1 1 0 Membrane transport protein Sacchrp_dh_C PF16653.5 CCF47336.1 - 0.084 13.0 0.0 0.17 12.0 0.0 1.6 1 0 0 1 1 1 0 Saccharopine dehydrogenase C-terminal domain Glyoxalase PF00903.25 CCF47337.1 - 0.00021 21.5 1.3 0.00027 21.1 1.3 1.2 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily zf-RING_2 PF13639.6 CCF47338.1 - 1.1e-10 41.6 4.9 1.7e-10 41.0 4.9 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 CCF47338.1 - 5.2e-07 29.9 5.4 2.3e-06 27.8 5.4 1.9 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 CCF47338.1 - 1.4e-06 28.3 0.8 2.2e-06 27.6 0.8 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 CCF47338.1 - 3.1e-05 23.9 1.8 4e-05 23.5 1.1 1.6 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 CCF47338.1 - 4.1e-05 23.3 5.9 0.00025 20.8 6.3 2.0 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CCF47338.1 - 8.1e-05 22.4 2.3 0.00016 21.4 2.2 1.5 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CCF47338.1 - 0.0016 18.3 2.8 0.0027 17.5 2.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CCF47338.1 - 0.0028 17.5 4.9 0.21 11.5 1.7 2.3 2 0 0 2 2 2 2 Prokaryotic RING finger family 4 UBZ_FAAP20 PF15750.5 CCF47338.1 - 0.0058 16.5 1.0 1.2 9.2 0.1 2.5 2 0 0 2 2 2 1 Ubiquitin-binding zinc-finger zf-RING_4 PF14570.6 CCF47338.1 - 0.0082 15.9 3.5 0.02 14.7 3.6 1.7 1 1 0 1 1 1 1 RING/Ubox like zinc-binding domain FANCL_C PF11793.8 CCF47338.1 - 0.0088 16.2 2.6 0.28 11.4 2.6 2.4 1 1 0 1 1 1 1 FANCL C-terminal domain Rad50_zn_hook PF04423.14 CCF47338.1 - 0.0096 15.7 1.7 0.49 10.3 0.1 2.4 2 0 0 2 2 2 1 Rad50 zinc hook motif zf-RING_11 PF17123.5 CCF47338.1 - 0.025 14.3 1.2 0.025 14.3 1.2 1.6 2 0 0 2 2 2 0 RING-like zinc finger zf-Di19 PF05605.12 CCF47338.1 - 0.038 14.3 1.8 6.8 7.1 0.3 2.4 2 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Prok-RING_1 PF14446.6 CCF47338.1 - 0.048 13.6 4.1 3.2 7.8 0.2 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 zf-RING_5 PF14634.6 CCF47338.1 - 0.07 13.1 1.6 0.13 12.3 1.6 1.5 1 0 0 1 1 1 0 zinc-RING finger domain zf-UDP PF14569.6 CCF47338.1 - 0.25 11.5 4.0 1.1 9.4 4.0 1.9 1 1 0 1 1 1 0 Zinc-binding RING-finger Zn-C2H2_12 PF18112.1 CCF47338.1 - 0.26 11.8 3.4 5.1 7.7 0.1 2.6 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain Tmpp129 PF10272.9 CCF47338.1 - 0.31 10.3 1.8 0.37 10.0 0.4 1.7 2 0 0 2 2 2 0 Putative transmembrane protein precursor Fungal_trans PF04082.18 CCF47339.1 - 1e-23 83.7 0.0 1.4e-23 83.3 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain DLH PF01738.18 CCF47340.1 - 1.5e-16 60.6 0.0 1.9e-16 60.3 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_1 PF00561.20 CCF47340.1 - 2.1e-05 24.3 0.0 2.8e-05 23.9 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Chlorophyllase PF07224.11 CCF47340.1 - 0.018 14.1 0.0 0.027 13.5 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase Translin PF01997.16 CCF47341.1 - 5.6e-33 114.7 0.2 6.3e-33 114.5 0.2 1.0 1 0 0 1 1 1 1 Translin family Ank_5 PF13857.6 CCF47342.1 - 0.0015 18.8 0.1 0.0041 17.4 0.0 1.8 2 0 0 2 2 2 1 Ankyrin repeats (many copies) PADR1 PF08063.12 CCF47342.1 - 0.15 11.8 0.2 8.9 6.2 0.1 2.2 2 0 0 2 2 2 0 PADR1 (NUC008) domain Methyltransf_23 PF13489.6 CCF47343.1 - 3.4e-20 72.5 0.0 6.4e-20 71.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF47343.1 - 8.6e-12 45.1 0.0 1e-10 41.6 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF47343.1 - 1e-10 42.1 0.0 2.7e-10 40.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF47343.1 - 4e-07 30.6 0.0 1e-06 29.3 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF47343.1 - 0.00022 21.9 0.0 0.0033 18.1 0.0 2.5 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CCF47343.1 - 0.0031 17.1 0.0 0.0061 16.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain FtsJ PF01728.19 CCF47343.1 - 0.0053 16.9 0.0 0.0076 16.4 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_4 PF02390.17 CCF47343.1 - 0.0064 16.0 0.0 0.017 14.6 0.0 1.7 1 0 0 1 1 1 1 Putative methyltransferase CheR PF01739.18 CCF47343.1 - 0.0078 15.7 0.0 0.013 15.0 0.0 1.2 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain PrmA PF06325.13 CCF47343.1 - 0.021 14.2 0.0 0.031 13.7 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_16 PF10294.9 CCF47343.1 - 0.024 14.4 0.0 0.039 13.7 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_2 PF00891.18 CCF47343.1 - 0.096 12.0 0.0 0.62 9.3 0.0 1.9 1 1 0 1 1 1 0 O-methyltransferase domain CBM_1 PF00734.18 CCF47345.1 - 1.6e-12 47.1 10.2 1.6e-12 47.1 10.2 2.1 2 0 0 2 2 2 1 Fungal cellulose binding domain Toxin_7 PF05980.12 CCF47345.1 - 0.15 12.3 0.5 0.37 11.1 0.5 1.7 1 0 0 1 1 1 0 Toxin 7 4HBT PF03061.22 CCF47347.1 - 5.8e-07 29.8 0.2 1e-06 29.0 0.2 1.4 1 0 0 1 1 1 1 Thioesterase superfamily MARVEL PF01284.23 CCF47348.1 - 0.00012 22.2 15.3 0.00017 21.7 15.3 1.2 1 0 0 1 1 1 1 Membrane-associating domain DUF4293 PF14126.6 CCF47348.1 - 0.0055 17.0 3.3 0.0055 17.0 3.3 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4293) 7TMR-DISM_7TM PF07695.11 CCF47348.1 - 0.24 11.3 16.4 0.38 10.6 11.6 2.0 2 0 0 2 2 2 0 7TM diverse intracellular signalling Myc_target_1 PF15179.6 CCF47348.1 - 2 8.3 9.1 2.4 8.0 2.4 2.1 2 0 0 2 2 2 0 Myc target protein 1 DUF1772 PF08592.11 CCF47351.1 - 1e-29 103.6 10.9 1.3e-29 103.3 10.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1772) MFS_1 PF07690.16 CCF47352.1 - 8.9e-16 57.8 18.6 1.1e-15 57.5 18.6 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily HET PF06985.11 CCF47353.1 - 8.1e-33 113.8 0.1 1.3e-32 113.1 0.1 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Pico_P1A PF02226.16 CCF47353.1 - 0.11 12.5 0.0 0.33 11.0 0.0 1.7 1 0 0 1 1 1 0 Picornavirus coat protein (VP4) Methyltransf_25 PF13649.6 CCF47354.1 - 1.4e-14 54.5 0.0 2.9e-14 53.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF47354.1 - 1.6e-14 54.3 0.0 3.7e-14 53.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCF47354.1 - 4.5e-12 45.8 0.0 9.1e-12 44.8 0.0 1.4 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 CCF47354.1 - 5.4e-09 36.7 0.0 8.5e-09 36.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF47354.1 - 1.7e-08 34.4 0.0 2.2e-08 34.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF47354.1 - 4.6e-07 29.8 0.0 6.5e-07 29.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CCF47354.1 - 0.054 13.0 0.0 0.17 11.4 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase small domain CoA_binding_3 PF13727.6 CCF47355.1 - 0.3 11.1 0.0 0.3 11.1 0.0 2.0 2 0 0 2 2 2 0 CoA-binding domain Peptidase_S8 PF00082.22 CCF47359.1 - 7.4e-06 25.4 1.3 1.2e-05 24.8 1.3 1.3 1 0 0 1 1 1 1 Subtilase family Cytochrom_C PF00034.21 CCF47361.1 - 3.7e-12 47.2 0.1 5.1e-12 46.8 0.1 1.2 1 0 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 CCF47361.1 - 3.5e-09 36.9 2.2 1.3e-08 35.1 2.2 1.7 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.6 CCF47361.1 - 0.02 14.6 2.4 0.11 12.3 2.4 2.2 1 1 0 1 1 1 0 Cytochrome c-550 domain AAA PF00004.29 CCF47362.1 - 2.7e-64 215.5 0.0 2.6e-45 154.1 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CCF47362.1 - 3.8e-13 49.0 0.8 3.2e-05 23.6 0.1 2.8 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 CCF47362.1 - 2.9e-10 40.8 1.0 0.00045 20.6 0.0 4.6 3 2 1 4 4 4 2 AAA ATPase domain AAA_22 PF13401.6 CCF47362.1 - 2e-08 34.6 0.6 0.017 15.4 0.0 5.7 5 2 1 6 6 4 1 AAA domain AAA_5 PF07728.14 CCF47362.1 - 2.7e-08 33.9 0.1 0.0032 17.5 0.0 3.0 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 CCF47362.1 - 1.5e-06 28.0 0.0 0.00035 20.3 0.0 2.4 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 CCF47362.1 - 2e-06 28.4 0.2 0.06 13.9 0.0 3.1 3 1 0 3 3 2 2 AAA domain AAA_33 PF13671.6 CCF47362.1 - 1e-05 25.7 0.0 0.0044 17.2 0.0 2.9 2 1 0 2 2 2 1 AAA domain AAA_17 PF13207.6 CCF47362.1 - 6.1e-05 23.5 0.1 0.57 10.6 0.0 3.5 3 0 0 3 3 3 2 AAA domain Rad17 PF03215.15 CCF47362.1 - 7.4e-05 22.8 0.0 0.068 13.1 0.0 2.5 2 1 0 2 2 2 1 Rad17 P-loop domain Zeta_toxin PF06414.12 CCF47362.1 - 0.0001 21.6 0.8 0.036 13.3 0.0 3.3 4 0 0 4 4 3 1 Zeta toxin AAA_2 PF07724.14 CCF47362.1 - 0.00011 22.4 0.0 0.0017 18.5 0.0 2.6 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) Sigma54_activ_2 PF14532.6 CCF47362.1 - 0.00017 21.8 0.0 0.13 12.4 0.0 2.9 2 1 0 2 2 2 1 Sigma-54 interaction domain IstB_IS21 PF01695.17 CCF47362.1 - 0.00019 21.2 0.0 0.03 14.1 0.0 2.4 2 0 0 2 2 2 1 IstB-like ATP binding protein RNA_helicase PF00910.22 CCF47362.1 - 0.00044 20.6 0.0 0.052 13.9 0.0 2.7 2 0 0 2 2 2 1 RNA helicase AAA_28 PF13521.6 CCF47362.1 - 0.0005 20.4 3.4 0.88 9.8 0.0 3.5 4 1 0 4 4 2 2 AAA domain AAA_14 PF13173.6 CCF47362.1 - 0.00052 20.1 0.0 0.057 13.4 0.0 2.6 3 0 0 3 3 2 1 AAA domain DUF815 PF05673.13 CCF47362.1 - 0.00068 18.9 0.0 0.64 9.1 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF815) Sigma54_activat PF00158.26 CCF47362.1 - 0.00068 19.4 0.0 0.67 9.6 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain Mg_chelatase PF01078.21 CCF47362.1 - 0.00073 19.0 0.1 0.1 11.9 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_7 PF12775.7 CCF47362.1 - 0.0021 17.6 0.0 0.73 9.3 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_11 PF13086.6 CCF47362.1 - 0.0021 17.9 2.9 1.1 9.0 0.0 3.1 3 0 0 3 3 3 1 AAA domain AAA_25 PF13481.6 CCF47362.1 - 0.0046 16.6 0.2 5.3 6.6 0.0 4.0 3 1 1 4 4 4 0 AAA domain TIP49 PF06068.13 CCF47362.1 - 0.0073 15.6 0.0 0.27 10.4 0.0 2.2 2 0 0 2 2 2 1 TIP49 P-loop domain NACHT PF05729.12 CCF47362.1 - 0.013 15.4 0.0 5.1 7.0 0.0 3.4 3 1 1 4 4 4 0 NACHT domain Vps4_C PF09336.10 CCF47362.1 - 0.017 15.1 0.0 3.4 7.7 0.0 3.5 3 0 0 3 3 3 0 Vps4 C terminal oligomerisation domain TniB PF05621.11 CCF47362.1 - 0.021 14.2 0.0 0.75 9.2 0.0 3.2 4 1 0 4 4 4 0 Bacterial TniB protein AAA_24 PF13479.6 CCF47362.1 - 0.024 14.4 0.0 3.3 7.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 CCF47362.1 - 0.025 15.1 0.1 2.6 8.6 0.0 2.9 3 0 0 3 3 2 0 ABC transporter AAA_3 PF07726.11 CCF47362.1 - 0.053 13.4 0.0 2.4 8.0 0.0 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 CCF47362.1 - 0.061 13.3 0.0 1.7 8.6 0.0 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_19 PF13245.6 CCF47362.1 - 0.064 13.6 0.0 9 6.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 CCF47362.1 - 0.07 12.9 0.0 1.3 8.7 0.0 2.3 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase SKI PF01202.22 CCF47362.1 - 0.085 13.0 0.2 10 6.2 0.0 3.2 3 0 0 3 3 3 0 Shikimate kinase IPT PF01745.16 CCF47362.1 - 0.1 12.0 0.7 5.9 6.2 0.0 2.8 3 0 0 3 3 3 0 Isopentenyl transferase DUF498 PF04430.14 CCF47362.1 - 0.13 12.4 0.0 3.4 7.8 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF498/DUF598) AAA_30 PF13604.6 CCF47362.1 - 0.13 12.0 0.0 20 4.8 0.0 2.7 3 0 0 3 3 2 0 AAA domain NB-ARC PF00931.22 CCF47362.1 - 0.16 11.1 0.0 1 8.5 0.0 2.3 3 0 0 3 3 3 0 NB-ARC domain Adeno_IVa2 PF02456.15 CCF47362.1 - 0.2 10.4 0.0 0.71 8.6 0.0 1.8 2 0 0 2 2 2 0 Adenovirus IVa2 protein CRM1_C PF08767.11 CCF47363.1 - 9.2e-136 452.2 3.5 9.2e-136 452.2 3.5 2.6 2 1 1 3 3 3 1 CRM1 C terminal CRM1_repeat_2 PF18784.1 CCF47363.1 - 6.8e-34 115.3 4.0 2e-33 113.9 4.0 1.9 1 0 0 1 1 1 1 CRM1 / Exportin repeat 2 CRM1_repeat_3 PF18787.1 CCF47363.1 - 1.2e-27 95.7 0.8 1.2e-27 95.7 0.8 3.4 5 0 0 5 5 5 1 CRM1 / Exportin repeat 3 MMS19_C PF12460.8 CCF47363.1 - 0.00021 20.5 4.0 0.0057 15.8 1.8 3.1 2 1 1 3 3 3 1 RNAPII transcription regulator C-terminal DUF3385 PF11865.8 CCF47363.1 - 0.0015 18.5 2.0 0.18 11.7 0.1 3.5 3 1 0 4 4 4 1 Domain of unknown function (DUF3385) Hemocyanin_M PF00372.19 CCF47363.1 - 0.11 11.6 0.3 0.77 8.9 0.0 2.4 2 1 1 3 3 3 0 Hemocyanin, copper containing domain Prolamin_like PF05617.11 CCF47363.1 - 0.16 12.2 0.2 3.2 8.0 0.1 2.7 2 0 0 2 2 2 0 Prolamin-like Vac14_Fab1_bd PF12755.7 CCF47363.1 - 0.19 12.4 5.5 2 9.0 0.0 4.2 5 1 1 6 6 6 0 Vacuolar 14 Fab1-binding region FliH PF02108.16 CCF47363.1 - 0.23 11.5 3.4 1.1 9.4 0.0 3.1 3 0 0 3 3 3 0 Flagellar assembly protein FliH SDH_beta PF03315.15 CCF47364.1 - 0.019 15.3 0.0 0.021 15.2 0.0 1.2 1 0 0 1 1 1 0 Serine dehydratase beta chain Fungal_trans PF04082.18 CCF47365.1 - 4.1e-10 39.2 0.0 7.3e-10 38.3 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain UBD PF16455.5 CCF47367.1 - 6.3e-10 39.2 0.1 9.5e-10 38.7 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-binding domain Ribosomal_L13 PF00572.18 CCF47368.1 - 4.6e-11 43.0 0.0 4.1e-09 36.8 0.0 2.3 1 1 0 1 1 1 1 Ribosomal protein L13 DSBA PF01323.20 CCF47368.1 - 0.014 15.2 0.1 0.021 14.6 0.1 1.2 1 1 0 1 1 1 0 DSBA-like thioredoxin domain Pyr_redox_2 PF07992.14 CCF47369.1 - 6.5e-11 42.0 0.0 1.3e-07 31.2 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCF47369.1 - 0.0054 16.4 0.0 0.0098 15.5 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 CCF47369.1 - 0.09 12.8 0.0 0.22 11.5 0.0 1.6 2 0 0 2 2 2 0 FAD-NAD(P)-binding Malic_M PF03949.15 CCF47369.1 - 0.15 11.3 0.0 0.74 9.0 0.0 1.8 2 0 0 2 2 2 0 Malic enzyme, NAD binding domain Methyltransf_24 PF13578.6 CCF47370.1 - 3.9e-05 24.6 0.0 5.3e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain zf-C2H2 PF00096.26 CCF47372.1 - 8.1e-06 26.0 3.7 8.1e-06 26.0 3.7 5.0 4 1 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCF47372.1 - 2e-05 25.0 2.5 2e-05 25.0 2.5 5.6 5 1 0 5 5 5 1 C2H2-type zinc finger zf-H2C2_2 PF13465.6 CCF47372.1 - 3.1e-05 24.2 4.2 3.1e-05 24.2 4.2 4.4 5 1 0 5 5 5 1 Zinc-finger double domain zf-C2H2_8 PF15909.5 CCF47372.1 - 6.1e-05 23.2 4.1 0.0002 21.6 3.9 1.9 2 0 0 2 2 2 1 C2H2-type zinc ribbon zf-C2H2_jaz PF12171.8 CCF47372.1 - 0.00014 22.1 5.1 0.0003 21.0 1.1 3.3 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding Actin_micro PF17003.5 CCF47372.1 - 0.26 10.4 2.3 3.7 6.6 2.3 2.4 1 1 0 1 1 1 0 Putative actin-like family GATA PF00320.27 CCF47376.1 - 2.6e-10 39.7 1.2 5e-10 38.8 1.2 1.5 1 0 0 1 1 1 1 GATA zinc finger Zn-ribbon_8 PF09723.10 CCF47376.1 - 0.14 12.3 1.6 0.3 11.3 1.6 1.5 1 0 0 1 1 1 0 Zinc ribbon domain DUF3405 PF11885.8 CCF47377.1 - 2.3e-50 171.7 0.4 2.5e-50 171.6 0.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3405) BNR_4 PF15892.5 CCF47377.1 - 0.013 14.9 0.0 0.017 14.5 0.0 1.1 1 0 0 1 1 1 0 BNR repeat-containing family member bZIP_1 PF00170.21 CCF47378.1 - 6.8e-08 32.5 15.3 1.2e-07 31.7 15.3 1.4 1 0 0 1 1 1 1 bZIP transcription factor PAP1 PF08601.10 CCF47378.1 - 3.2e-05 23.8 17.2 5.4e-05 23.1 0.0 2.2 1 1 1 2 2 2 1 Transcription factor PAP1 V_ATPase_I PF01496.19 CCF47378.1 - 0.0012 16.9 2.1 0.0014 16.6 2.1 1.1 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family SHE3 PF17078.5 CCF47378.1 - 0.0014 18.4 5.7 0.0019 18.0 5.7 1.1 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 bZIP_Maf PF03131.17 CCF47378.1 - 0.0026 18.2 11.0 0.004 17.6 11.0 1.3 1 0 0 1 1 1 1 bZIP Maf transcription factor ADIP PF11559.8 CCF47378.1 - 0.013 15.6 11.2 0.02 15.0 11.2 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding DivIC PF04977.15 CCF47378.1 - 0.04 13.7 4.7 0.078 12.8 4.7 1.4 1 0 0 1 1 1 0 Septum formation initiator DUF641 PF04859.12 CCF47378.1 - 0.043 14.2 5.5 0.066 13.5 5.5 1.2 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) DUF2381 PF09544.10 CCF47378.1 - 0.043 13.3 1.7 0.069 12.7 1.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2381) YabA PF06156.13 CCF47378.1 - 0.055 14.1 0.2 0.095 13.3 0.2 1.3 1 0 0 1 1 1 0 Initiation control protein YabA bZIP_2 PF07716.15 CCF47378.1 - 0.12 12.5 17.9 0.36 10.9 16.3 2.1 1 1 1 2 2 2 0 Basic region leucine zipper DUF4349 PF14257.6 CCF47378.1 - 0.31 10.4 3.5 0.47 9.9 3.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) TSC22 PF01166.18 CCF47378.1 - 0.69 10.3 3.3 9.8 6.6 1.4 2.3 1 1 1 2 2 2 0 TSC-22/dip/bun family GvpL_GvpF PF06386.11 CCF47378.1 - 0.78 9.6 8.6 1.2 9.1 8.6 1.2 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF APG6_N PF17675.1 CCF47378.1 - 0.85 10.2 10.1 1.3 9.6 10.1 1.2 1 0 0 1 1 1 0 Apg6 coiled-coil region UPF0242 PF06785.11 CCF47378.1 - 1.7 8.7 6.6 2.5 8.1 6.6 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus M PF02370.16 CCF47378.1 - 7.5 7.5 8.1 1.4 9.7 3.7 2.1 2 0 0 2 2 2 0 M protein repeat MFS_1 PF07690.16 CCF47379.1 - 6.9e-22 77.8 30.1 6.9e-22 77.8 30.1 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily LysM PF01476.20 CCF47381.1 - 1.6e-13 50.5 0.0 3.6e-06 26.9 0.0 3.2 3 0 0 3 3 3 2 LysM domain Mucin PF01456.17 CCF47381.1 - 0.3 11.1 19.4 0.28 11.2 14.1 2.3 2 0 0 2 2 2 0 Mucin-like glycoprotein Dak1 PF02733.17 CCF47384.1 - 4.9e-45 153.8 0.3 5.4e-45 153.6 0.3 1.0 1 0 0 1 1 1 1 Dak1 domain EF-hand_7 PF13499.6 CCF47386.1 - 8.9e-07 29.3 0.2 1.8e-06 28.3 0.1 1.6 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 CCF47386.1 - 0.00018 20.8 3.4 0.29 10.8 0.0 2.9 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 CCF47386.1 - 0.053 13.5 1.2 0.43 10.6 0.1 2.6 3 0 0 3 3 3 0 EF-hand domain EF-hand_8 PF13833.6 CCF47386.1 - 0.14 12.1 0.0 2 8.3 0.0 2.6 3 0 0 3 3 3 0 EF-hand domain pair Gar1 PF04410.14 CCF47388.1 - 2.5e-25 89.0 0.0 2.5e-25 89.0 0.0 2.0 2 0 0 2 2 2 1 Gar1/Naf1 RNA binding region Abhydrolase_1 PF00561.20 CCF47389.1 - 1.3e-19 70.9 0.0 1.7e-15 57.4 0.1 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_4 PF08386.10 CCF47389.1 - 6.2e-13 48.8 0.0 1.1e-12 48.0 0.0 1.3 1 0 0 1 1 1 1 TAP-like protein zf-C2H2_4 PF13894.6 CCF47390.1 - 9.4e-06 26.0 14.0 0.011 16.5 0.4 3.8 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2 PF00096.26 CCF47390.1 - 0.00067 20.0 0.6 0.00067 20.0 0.6 3.9 3 2 0 3 3 3 2 Zinc finger, C2H2 type zf-Di19 PF05605.12 CCF47390.1 - 0.0028 17.9 6.8 0.051 13.9 0.7 2.6 2 0 0 2 2 2 2 Drought induced 19 protein (Di19), zinc-binding zf-C2HE PF16278.5 CCF47390.1 - 0.017 15.5 5.1 0.73 10.3 1.9 2.6 2 0 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-H2C2_5 PF13909.6 CCF47390.1 - 0.33 10.7 0.1 0.33 10.7 0.1 4.1 3 1 1 4 4 4 0 C2H2-type zinc-finger domain Rad50_zn_hook PF04423.14 CCF47390.1 - 0.72 9.7 2.5 1.9 8.4 0.4 2.3 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-C2H2_2 PF12756.7 CCF47390.1 - 1.5 9.2 6.7 8.7 6.7 0.4 2.7 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-BED PF02892.15 CCF47390.1 - 2.6 8.1 7.0 1.7 8.7 3.3 2.5 2 1 1 3 3 3 0 BED zinc finger zf-H2C2_2 PF13465.6 CCF47390.1 - 4.2 8.0 15.3 28 5.4 1.3 4.4 4 0 0 4 4 4 0 Zinc-finger double domain p450 PF00067.22 CCF47392.1 - 2.8e-05 23.0 0.0 3.3e-05 22.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 LysM PF01476.20 CCF47393.1 - 1.1e-05 25.3 0.0 1.8e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 LysM domain FAT PF02259.23 CCF47395.1 - 6e-08 32.3 0.0 1e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 FAT domain TPR_19 PF14559.6 CCF47395.1 - 0.0016 18.9 0.1 0.0064 17.0 0.0 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat LSM14 PF12701.7 CCF47396.1 - 1.4e-32 111.6 0.1 1.8e-32 111.2 0.1 1.2 1 0 0 1 1 1 1 Scd6-like Sm domain SM-ATX PF14438.6 CCF47396.1 - 4.4e-08 33.2 0.0 7.2e-08 32.5 0.0 1.3 1 0 0 1 1 1 1 Ataxin 2 SM domain TPR_1 PF00515.28 CCF47397.1 - 8.6e-45 148.8 26.0 1.7e-08 33.9 0.0 8.9 9 1 0 9 9 9 6 Tetratricopeptide repeat TPR_2 PF07719.17 CCF47397.1 - 9.1e-40 131.6 19.0 4.3e-07 29.5 0.0 8.4 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_8 PF13181.6 CCF47397.1 - 5.5e-32 107.3 18.6 8.2e-08 31.9 0.0 8.4 8 1 0 8 8 8 6 Tetratricopeptide repeat TPR_16 PF13432.6 CCF47397.1 - 1.4e-26 92.9 9.4 2.7e-08 34.3 0.0 5.3 3 2 2 5 5 5 5 Tetratricopeptide repeat TPR_17 PF13431.6 CCF47397.1 - 1.6e-25 87.6 7.9 0.00063 20.0 0.0 8.0 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_11 PF13414.6 CCF47397.1 - 1.2e-22 79.3 26.3 9.4e-07 28.4 0.2 8.1 4 3 5 9 9 9 4 TPR repeat TPR_14 PF13428.6 CCF47397.1 - 6.6e-21 73.2 12.3 1.2e-05 25.7 0.1 7.1 3 2 5 8 8 8 5 Tetratricopeptide repeat TPR_19 PF14559.6 CCF47397.1 - 1.3e-20 73.6 13.2 4.1e-05 24.0 0.1 5.4 4 2 1 5 5 5 4 Tetratricopeptide repeat TPR_6 PF13174.6 CCF47397.1 - 4.1e-20 71.0 13.7 0.00038 20.9 0.0 7.8 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_12 PF13424.6 CCF47397.1 - 2.3e-19 69.5 16.7 1e-05 25.7 1.0 6.4 3 1 2 5 5 5 4 Tetratricopeptide repeat TPR_7 PF13176.6 CCF47397.1 - 1.7e-17 62.1 13.2 0.0026 17.6 0.1 7.4 7 1 0 7 7 7 4 Tetratricopeptide repeat TPR_9 PF13371.6 CCF47397.1 - 5.4e-15 55.3 11.3 0.00024 21.2 0.1 5.2 2 2 4 6 6 6 5 Tetratricopeptide repeat TPR_15 PF13429.6 CCF47397.1 - 5.9e-10 38.8 6.3 0.023 13.9 0.1 4.9 1 1 4 5 5 5 5 Tetratricopeptide repeat ANAPC3 PF12895.7 CCF47397.1 - 3e-09 37.0 1.1 3e-09 37.0 1.1 3.4 4 1 1 5 5 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_21 PF09976.9 CCF47397.1 - 3.1e-07 30.3 6.4 0.0036 17.0 0.0 4.6 3 1 1 5 5 5 2 Tetratricopeptide repeat-like domain DUF2225 PF09986.9 CCF47397.1 - 0.00087 19.1 1.6 0.55 9.9 0.0 3.2 1 1 2 3 3 3 1 Uncharacterized protein conserved in bacteria (DUF2225) TPR_20 PF14561.6 CCF47397.1 - 0.0046 17.3 1.5 0.32 11.4 0.0 3.8 3 1 2 5 5 5 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 CCF47397.1 - 0.0054 16.8 0.0 8.5 6.5 0.0 3.8 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_10 PF13374.6 CCF47397.1 - 0.041 13.8 18.1 4.1 7.4 0.1 6.7 8 0 0 8 8 7 0 Tetratricopeptide repeat DUF627 PF04781.12 CCF47397.1 - 0.062 13.3 0.3 11 6.1 0.6 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF627) SNAP PF14938.6 CCF47397.1 - 0.073 12.5 16.6 2.9 7.3 2.3 4.2 2 1 2 4 4 4 0 Soluble NSF attachment protein, SNAP BTAD PF03704.17 CCF47397.1 - 0.097 13.1 2.3 1.8 9.0 0.1 2.6 1 1 0 2 2 2 0 Bacterial transcriptional activator domain GAS PF13851.6 CCF47397.1 - 0.26 10.6 1.1 0.41 10.0 0.3 1.7 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding DUF410 PF04190.13 CCF47397.1 - 0.42 10.4 3.4 3.6 7.3 0.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF410) MIT PF04212.18 CCF47397.1 - 4.9 7.3 22.7 4.5 7.4 1.8 6.3 7 0 0 7 7 7 0 MIT (microtubule interacting and transport) domain MFS_1 PF07690.16 CCF47399.1 - 1e-15 57.6 34.2 1e-15 57.6 34.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily p450 PF00067.22 CCF47400.1 - 2.7e-37 128.6 0.0 3.8e-37 128.1 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 CCF47401.1 - 9.7e-72 242.2 0.0 1.3e-71 241.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 CCF47402.1 - 3.8e-33 114.9 0.0 4.4e-33 114.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 GST_N_4 PF17172.4 CCF47404.1 - 2.1e-18 66.9 0.0 5e-18 65.7 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C_6 PF17171.4 CCF47404.1 - 1e-06 28.4 0.0 2.7e-06 27.1 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Tom37 PF10568.9 CCF47404.1 - 0.0058 16.9 0.0 0.0098 16.2 0.0 1.3 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_C_2 PF13410.6 CCF47404.1 - 0.11 12.5 0.0 0.25 11.4 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain UPF0183 PF03676.14 CCF47405.1 - 5.2e-54 184.0 0.0 3.5e-31 108.9 0.0 3.6 3 1 0 3 3 3 3 Uncharacterised protein family (UPF0183) Acetyltransf_1 PF00583.25 CCF47406.1 - 3.7e-05 23.9 0.7 7.2e-05 23.0 0.6 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CCF47406.1 - 0.0005 20.0 0.1 0.0012 18.7 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CCF47406.1 - 0.00094 19.6 0.5 0.0018 18.7 0.5 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Kinesin PF00225.23 CCF47407.1 - 8.4e-108 360.2 0.0 8.4e-108 360.2 0.0 2.2 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 CCF47407.1 - 4.9e-24 85.0 0.1 4.8e-23 81.7 0.0 3.0 2 0 0 2 2 2 1 Microtubule binding Microtub_bind PF13931.6 CCF47407.1 - 2.3e-07 31.2 0.2 2.3e-07 31.2 0.2 5.6 3 1 3 6 6 6 1 Kinesin-associated microtubule-binding Apolipoprotein PF01442.18 CCF47407.1 - 2.5e-05 24.2 73.7 0.0046 16.8 15.6 4.6 1 1 3 4 4 4 3 Apolipoprotein A1/A4/E domain Halogen_Hydrol PF10112.9 CCF47407.1 - 0.0028 17.7 4.5 0.0028 17.7 4.5 4.9 4 1 0 5 5 5 1 5-bromo-4-chloroindolyl phosphate hydrolysis protein RGS_DHEX PF18148.1 CCF47407.1 - 0.25 11.5 4.4 0.63 10.2 1.0 3.0 2 0 0 2 2 2 0 Regulator of G-protein signalling DHEX domain HTH_psq PF05225.16 CCF47408.1 - 9e-10 38.1 0.1 1.3e-09 37.6 0.1 1.4 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.16 CCF47408.1 - 0.00091 19.2 0.1 0.0035 17.3 0.0 1.9 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_23 PF13384.6 CCF47408.1 - 0.001 18.8 0.1 0.0031 17.2 0.0 1.7 1 1 0 2 2 2 1 Homeodomain-like domain CENP-B_N PF04218.13 CCF47408.1 - 0.0053 16.4 0.0 0.0075 15.9 0.0 1.2 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_28 PF13518.6 CCF47408.1 - 0.028 14.5 0.1 0.063 13.4 0.0 1.7 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_8 PF02954.19 CCF47408.1 - 0.036 13.9 0.6 0.22 11.3 0.0 2.3 2 1 1 3 3 3 0 Bacterial regulatory protein, Fis family HTH_Tnp_ISL3 PF13542.6 CCF47408.1 - 0.096 12.1 0.0 0.19 11.2 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 HTH_50 PF18024.1 CCF47408.1 - 0.14 11.8 0.0 0.23 11.1 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain Sugar_tr PF00083.24 CCF47413.1 - 4.2e-15 55.6 0.3 4.7e-15 55.4 0.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF47413.1 - 0.00059 18.9 0.1 0.00063 18.8 0.1 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily CoaE PF01121.20 CCF47413.1 - 0.0012 18.6 0.0 0.0014 18.3 0.0 1.1 1 0 0 1 1 1 1 Dephospho-CoA kinase SET PF00856.28 CCF47414.1 - 6.6e-13 49.4 0.0 9.6e-12 45.6 0.0 2.2 1 1 0 1 1 1 1 SET domain SAF PF08666.12 CCF47414.1 - 0.066 13.8 0.1 9.4 7.0 0.0 2.5 2 0 0 2 2 2 0 SAF domain MFS_1 PF07690.16 CCF47415.1 - 6.9e-19 68.0 10.8 8.1e-19 67.7 10.8 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily FAD_binding_3 PF01494.19 CCF47417.1 - 1.4e-72 244.9 0.0 1.7e-72 244.6 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 CCF47417.1 - 2.1e-07 30.8 0.0 0.015 14.9 0.0 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCF47417.1 - 0.012 14.9 0.0 0.028 13.7 0.0 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCF47417.1 - 0.018 14.3 0.0 0.036 13.3 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CCF47417.1 - 0.027 13.7 0.0 0.049 12.9 0.0 1.3 1 0 0 1 1 1 0 Thi4 family NAD_binding_8 PF13450.6 CCF47417.1 - 0.038 14.2 0.0 0.1 12.9 0.0 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain SE PF08491.10 CCF47417.1 - 0.043 12.9 0.0 0.2 10.6 0.0 1.8 2 0 0 2 2 2 0 Squalene epoxidase Lycopene_cycl PF05834.12 CCF47417.1 - 0.048 12.7 0.0 0.087 11.9 0.0 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein HI0933_like PF03486.14 CCF47417.1 - 0.12 11.1 0.0 0.2 10.3 0.0 1.3 1 0 0 1 1 1 0 HI0933-like protein TrkA_N PF02254.18 CCF47417.1 - 0.16 12.3 0.0 0.54 10.5 0.0 1.8 2 0 0 2 2 2 0 TrkA-N domain MGC-24 PF05283.11 CCF47417.1 - 0.8 10.1 5.4 1.8 9.0 5.4 1.5 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Ank_2 PF12796.7 CCF47418.1 - 9.7e-79 260.0 0.0 3.4e-14 53.2 0.0 6.5 1 1 6 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CCF47418.1 - 1.5e-60 200.8 3.8 6e-15 55.4 0.0 7.6 2 2 6 8 8 8 8 Ankyrin repeats (many copies) Ank PF00023.30 CCF47418.1 - 5.8e-56 184.6 13.5 4.5e-08 33.2 0.0 10.4 10 0 0 10 10 10 10 Ankyrin repeat Ank_3 PF13606.6 CCF47418.1 - 5.6e-55 176.9 0.2 1.6e-06 28.0 0.0 10.4 10 0 0 10 10 10 9 Ankyrin repeat Ank_5 PF13857.6 CCF47418.1 - 2.9e-54 180.4 4.9 1.8e-11 44.1 0.1 9.4 1 1 8 9 9 9 9 Ankyrin repeats (many copies) Pkinase PF00069.25 CCF47418.1 - 1.4e-48 165.6 0.0 1.9e-48 165.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF47418.1 - 2.1e-32 112.5 0.0 3e-32 111.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CCF47418.1 - 0.016 14.6 0.0 0.028 13.8 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family MFS_1 PF07690.16 CCF47419.1 - 5.1e-17 61.8 15.5 5.8e-16 58.4 17.3 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF4064 PF13273.6 CCF47419.1 - 2.1 8.6 8.7 6.5 7.1 1.5 3.3 3 1 0 3 3 3 0 Protein of unknown function (DUF4064) Kelch_3 PF13415.6 CCF47420.1 - 0.52 10.7 3.8 1 9.7 0.4 2.7 1 1 1 3 3 3 0 Galactose oxidase, central domain S1FA PF04689.13 CCF47422.1 - 0.7 10.1 0.0 0.7 10.1 0.0 2.6 4 0 0 4 4 4 0 DNA binding protein S1FA IU_nuc_hydro PF01156.19 CCF47423.1 - 6.7e-57 193.4 0.0 1.1e-56 192.6 0.0 1.3 1 1 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase LSM PF01423.22 CCF47424.1 - 1.2e-15 56.9 0.0 1.5e-15 56.6 0.0 1.2 1 0 0 1 1 1 1 LSM domain Fig1 PF12351.8 CCF47425.1 - 3.1 7.7 8.3 6.9 6.5 8.3 1.6 1 0 0 1 1 1 0 Ca2+ regulator and membrane fusion protein Fig1 Na_Ca_ex PF01699.24 CCF47426.1 - 0.014 15.3 2.0 0.019 14.9 2.0 1.2 1 0 0 1 1 1 0 Sodium/calcium exchanger protein DUF202 PF02656.15 CCF47426.1 - 0.1 13.1 0.5 0.14 12.6 0.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF202) MLANA PF14991.6 CCF47426.1 - 0.12 12.6 0.0 0.18 12.1 0.0 1.4 1 0 0 1 1 1 0 Protein melan-A Y_phosphatase3 PF13350.6 CCF47428.1 - 3.6e-16 59.8 0.0 4.2e-16 59.6 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family WAPL PF07814.13 CCF47429.1 - 0.00051 18.9 0.5 0.072 11.9 0.0 2.3 1 1 1 2 2 2 2 Wings apart-like protein regulation of heterochromatin DUF2011 PF09428.10 CCF47431.1 - 0.094 13.0 0.0 0.12 12.6 0.0 1.2 1 0 0 1 1 1 0 Fungal protein of unknown function (DUF2011) CKAP2_C PF15297.6 CCF47432.1 - 0.25 10.4 0.1 0.32 10.0 0.1 1.1 1 0 0 1 1 1 0 Cytoskeleton-associated protein 2 C-terminus Chitin_synth_2 PF03142.15 CCF47434.1 - 1.6e-292 970.8 0.1 2.4e-292 970.2 0.1 1.3 1 0 0 1 1 1 1 Chitin synthase Glyco_trans_2_3 PF13632.6 CCF47434.1 - 2.1e-13 50.6 5.6 7.8e-13 48.8 5.6 2.0 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 CCF47434.1 - 2.6e-10 40.6 0.0 6.3e-10 39.3 0.0 1.6 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 CCF47434.1 - 9.2e-05 22.0 0.0 0.0031 17.0 0.0 2.2 2 0 0 2 2 2 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 CCF47434.1 - 0.013 15.3 0.0 0.047 13.5 0.0 1.9 1 0 0 1 1 1 0 Glycosyl transferase family 2 ISK_Channel PF02060.15 CCF47434.1 - 0.14 11.9 0.1 0.32 10.7 0.1 1.5 1 0 0 1 1 1 0 Slow voltage-gated potassium channel ARF7EP_C PF14949.6 CCF47435.1 - 2.8 8.6 7.7 0.38 11.4 2.1 2.1 2 0 0 2 2 2 0 ARF7 effector protein C-terminus Phe_hydrox_dim PF07976.12 CCF47436.1 - 0.14 12.2 0.0 0.18 11.8 0.0 1.1 1 0 0 1 1 1 0 Phenol hydroxylase, C-terminal dimerisation domain Peptidase_S8 PF00082.22 CCF47437.1 - 2.6e-18 66.3 0.2 3.3e-18 66.0 0.2 1.1 1 0 0 1 1 1 1 Subtilase family RVT_1 PF00078.27 CCF47438.1 - 2.3e-12 46.9 0.0 2.9e-12 46.6 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.24 CCF47439.1 - 1.2e-09 38.5 1.3 7.9e-07 29.4 0.1 2.1 1 1 1 2 2 2 2 RNase H HTH_psq PF05225.16 CCF47441.1 - 5.2e-06 26.1 0.0 1.3e-05 24.9 0.0 1.7 1 0 0 1 1 1 1 helix-turn-helix, Psq domain DDE_1 PF03184.19 CCF47441.1 - 0.0001 22.0 0.0 0.00015 21.5 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 CCF47441.1 - 0.00012 22.0 0.0 0.00031 20.7 0.0 1.8 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_AsnC-type PF13404.6 CCF47441.1 - 0.027 14.3 0.1 0.076 12.9 0.1 1.7 1 0 0 1 1 1 0 AsnC-type helix-turn-helix domain Acyl-CoA_dh_N PF02771.16 CCF47442.1 - 2.7e-24 86.0 0.0 5.4e-24 85.0 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 CCF47442.1 - 9e-22 77.1 0.4 1.4e-21 76.4 0.4 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 CCF47442.1 - 8.4e-21 74.7 1.4 1.3e-20 74.2 1.4 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain MutS_III PF05192.18 CCF47445.1 - 8e-05 22.9 0.3 0.00012 22.4 0.3 1.3 1 0 0 1 1 1 1 MutS domain III AAA_23 PF13476.6 CCF47445.1 - 0.0013 19.3 0.3 0.0038 17.8 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_27 PF13514.6 CCF47445.1 - 0.0023 17.6 0.1 0.0045 16.6 0.0 1.4 2 0 0 2 2 2 1 AAA domain AAA_21 PF13304.6 CCF47445.1 - 0.004 17.0 0.7 0.0076 16.1 0.3 1.6 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system MutS_V PF00488.21 CCF47445.1 - 0.0084 16.1 0.3 0.1 12.6 0.1 2.1 2 0 0 2 2 2 1 MutS domain V AAA_29 PF13555.6 CCF47445.1 - 0.013 15.2 0.1 0.02 14.6 0.1 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 CCF47445.1 - 0.021 15.3 0.4 0.17 12.4 0.4 2.0 1 1 1 2 2 2 0 ABC transporter Zeta_toxin PF06414.12 CCF47445.1 - 0.19 11.0 0.3 0.39 10.0 0.1 1.6 2 0 0 2 2 2 0 Zeta toxin AAA_15 PF13175.6 CCF47445.1 - 0.31 10.7 0.5 0.49 10.0 0.2 1.5 2 0 0 2 2 2 0 AAA ATPase domain Fungal_trans_2 PF11951.8 CCF47446.1 - 2.6e-28 98.9 0.0 3.4e-28 98.6 0.0 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain Ank_2 PF12796.7 CCF47447.1 - 2.8e-39 133.6 1.8 1e-12 48.4 0.2 5.4 3 1 1 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CCF47447.1 - 2.1e-35 120.7 2.4 1e-08 35.6 0.0 7.6 4 4 3 7 7 7 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCF47447.1 - 3.6e-28 94.5 1.6 0.0047 17.3 0.0 9.6 10 0 0 10 10 10 7 Ankyrin repeat Ank PF00023.30 CCF47447.1 - 2.7e-25 87.6 10.4 0.0015 18.9 0.0 9.4 10 0 0 10 10 10 7 Ankyrin repeat Ank_5 PF13857.6 CCF47447.1 - 4.5e-23 81.0 4.1 2.1e-06 27.9 0.0 7.5 3 2 5 8 8 8 4 Ankyrin repeats (many copies) Nitro_FeMo-Co PF02579.17 CCF47447.1 - 0.013 15.8 1.4 5.9 7.3 0.1 4.3 2 1 4 6 6 6 0 Dinitrogenase iron-molybdenum cofactor Ferric_reduct PF01794.19 CCF47449.1 - 1.1e-24 87.0 7.8 2.2e-24 85.9 7.8 1.6 1 0 0 1 1 1 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 CCF47449.1 - 4.2e-19 69.2 0.0 2.3e-16 60.3 0.0 2.4 1 1 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 CCF47449.1 - 1.1e-12 47.9 0.0 3.6e-11 43.1 0.0 2.4 1 1 0 1 1 1 1 FAD-binding domain DUF1345 PF07077.11 CCF47449.1 - 0.081 12.6 7.3 0.035 13.8 3.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1345) Arf PF00025.21 CCF47454.1 - 8.4e-75 250.0 0.1 9.7e-75 249.8 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 CCF47454.1 - 4.5e-14 52.7 0.0 6.1e-14 52.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 CCF47454.1 - 2.5e-12 46.7 0.0 2.8e-12 46.5 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 CCF47454.1 - 3.3e-12 46.2 2.4 1.9e-08 33.9 0.4 2.3 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 CCF47454.1 - 8.8e-12 44.8 0.0 1.1e-11 44.5 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 CCF47454.1 - 1.4e-10 40.9 0.1 1.8e-10 40.6 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 CCF47454.1 - 0.00051 20.1 0.0 0.00067 19.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 CCF47454.1 - 0.058 12.7 0.1 0.094 12.0 0.1 1.3 1 0 0 1 1 1 0 6-phosphofructo-2-kinase CRISPR_Cas2 PF09827.9 CCF47454.1 - 0.095 12.9 0.0 0.16 12.2 0.0 1.3 1 0 0 1 1 1 0 CRISPR associated protein Cas2 WD40 PF00400.32 CCF47458.1 - 5.7e-20 71.3 16.6 2.8e-05 24.8 0.6 5.4 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF47458.1 - 1.3e-09 38.3 1.4 0.0086 16.4 0.1 4.4 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CCF47458.1 - 0.0039 15.9 0.6 0.75 8.4 0.0 2.8 2 1 1 3 3 3 2 Nucleoporin Nup120/160 eIF2A PF08662.11 CCF47458.1 - 0.17 11.7 0.0 14 5.5 0.0 2.6 1 1 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A Peptidase_S8 PF00082.22 CCF47459.1 - 0.036 13.3 0.1 0.044 13.1 0.1 1.2 1 0 0 1 1 1 0 Subtilase family LNS2 PF08235.13 CCF47460.1 - 3.1e-20 72.6 0.0 4.3e-20 72.2 0.0 1.2 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Baculo_PP31 PF05311.11 CCF47462.1 - 0.19 11.2 0.0 0.23 10.9 0.0 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Git3 PF11710.8 CCF47463.1 - 9.8e-10 38.5 1.7 1.2e-09 38.3 1.7 1.0 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 Vma12 PF11712.8 CCF47463.1 - 3.6 7.7 4.3 0.35 10.9 0.3 1.5 2 0 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase COX8 PF02285.15 CCF47463.1 - 9.7 6.2 6.4 2.9 7.8 2.9 2.1 2 1 0 2 2 2 0 Cytochrome oxidase c subunit VIII Herpes_UL51 PF04540.13 CCF47464.1 - 0.03 14.1 0.0 0.032 13.9 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus UL51 protein PepSY_TM PF03929.16 CCF47464.1 - 0.11 12.1 0.2 0.11 12.1 0.2 1.0 1 0 0 1 1 1 0 PepSY-associated TM region GCS PF03074.16 CCF47465.1 - 4.4e-112 375.1 0.0 5.2e-112 374.8 0.0 1.0 1 0 0 1 1 1 1 Glutamate-cysteine ligase AA_permease_2 PF13520.6 CCF47466.1 - 4.9e-39 134.4 19.0 6.4e-39 134.0 19.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CCF47466.1 - 1.3e-16 60.3 18.2 1.5e-16 60.1 18.2 1.0 1 0 0 1 1 1 1 Amino acid permease HgmA PF04209.13 CCF47467.1 - 5.4e-198 657.9 0.0 6.2e-198 657.7 0.0 1.0 1 0 0 1 1 1 1 homogentisate 1,2-dioxygenase FAA_hydrolase PF01557.18 CCF47468.1 - 1.2e-58 198.4 0.0 1.6e-58 198.0 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FAA_hydrolase_N PF09298.11 CCF47468.1 - 4.2e-29 100.9 0.0 6.3e-29 100.3 0.0 1.3 1 0 0 1 1 1 1 Fumarylacetoacetase N-terminal Dabb PF07876.12 CCF47469.1 - 7e-15 55.4 0.0 8.3e-15 55.2 0.0 1.1 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain AMP-binding_C PF13193.6 CCF47470.1 - 1.6e-10 41.8 0.1 2e-10 41.5 0.1 1.2 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain E3_binding PF02817.17 CCF47471.1 - 0.0088 16.4 0.1 0.015 15.6 0.1 1.4 1 0 0 1 1 1 1 e3 binding domain TyrRSs_C PF16714.5 CCF47471.1 - 0.038 13.8 0.0 0.046 13.5 0.0 1.2 1 0 0 1 1 1 0 Tyrosyl-tRNA synthetase C-terminal domain DUF1524 PF07510.11 CCF47472.1 - 1.2e-09 38.2 0.0 1.6e-09 37.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1524) RRM_1 PF00076.22 CCF47477.1 - 2.1e-13 49.9 0.0 5.4e-13 48.6 0.0 1.7 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GTP_EFTU PF00009.27 CCF47478.1 - 6.7e-59 198.7 0.0 9.4e-59 198.2 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 CCF47478.1 - 3.3e-06 27.4 0.0 6.5e-06 26.4 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CCF47478.1 - 0.018 15.1 0.0 0.053 13.6 0.0 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase MPM1 PF17234.2 CCF47478.1 - 0.086 13.1 0.1 0.15 12.3 0.1 1.3 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 PRP3 PF08572.10 CCF47478.1 - 0.089 12.5 1.1 0.12 12.1 0.1 1.6 2 0 0 2 2 2 0 pre-mRNA processing factor 3 (PRP3) Paf67 PF10255.9 CCF47479.1 - 2.3e-155 517.6 0.3 2.8e-155 517.3 0.3 1.1 1 0 0 1 1 1 1 RNA polymerase I-associated factor PAF67 TPR_2 PF07719.17 CCF47479.1 - 0.019 15.1 0.0 0.11 12.7 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 CCF47479.1 - 0.068 13.0 0.0 0.35 10.8 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat MFS_1 PF07690.16 CCF47481.1 - 0.0001 21.4 30.0 0.0002 20.4 30.0 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF2236 PF09995.9 CCF47482.1 - 2.7e-05 24.5 1.7 3.1e-05 24.3 0.3 1.7 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2236) DUF3446 PF11928.8 CCF47483.1 - 0.018 15.3 3.4 0.033 14.5 3.4 1.4 1 0 0 1 1 1 0 Early growth response N-terminal domain Stimulus_sens_1 PF13756.6 CCF47484.1 - 0.037 14.6 0.1 0.093 13.3 0.1 1.7 1 0 0 1 1 1 0 Stimulus-sensing domain MDD_C PF18376.1 CCF47485.1 - 3.9e-63 212.6 0.0 5.3e-63 212.2 0.0 1.2 1 0 0 1 1 1 1 Mevalonate 5-diphosphate decarboxylase C-terminal domain GHMP_kinases_N PF00288.26 CCF47485.1 - 1.4e-08 34.8 2.5 1.9e-08 34.4 0.7 2.2 2 0 0 2 2 2 1 GHMP kinases N terminal domain DUF647 PF04884.14 CCF47486.1 - 1.7e-92 309.5 1.4 3.5e-92 308.4 0.6 1.7 2 0 0 2 2 2 1 Vitamin B6 photo-protection and homoeostasis ChitinaseA_N PF08329.10 CCF47487.1 - 0.16 11.7 0.1 0.26 11.0 0.1 1.2 1 0 0 1 1 1 0 Chitinase A, N-terminal domain DHQ_synthase PF01761.20 CCF47489.1 - 2.9e-38 131.5 0.0 4.2e-38 131.0 0.0 1.1 1 0 0 1 1 1 1 3-dehydroquinate synthase Fe-ADH_2 PF13685.6 CCF47489.1 - 0.00064 19.5 0.0 0.0012 18.6 0.0 1.4 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase DUF836 PF05768.14 CCF47490.1 - 3.6e-11 43.3 0.0 4.2e-11 43.1 0.0 1.1 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Glutaredoxin PF00462.24 CCF47490.1 - 0.00045 20.4 0.0 0.00061 20.0 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin DUF1223 PF06764.11 CCF47490.1 - 0.11 12.5 0.0 0.14 12.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1223) AMP-binding_C PF13193.6 CCF47491.1 - 3.8e-22 79.0 0.3 4.5e-22 78.8 0.3 1.1 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain HEAT_EZ PF13513.6 CCF47493.1 - 0.032 14.7 0.1 13 6.4 0.0 4.7 4 0 0 4 4 4 0 HEAT-like repeat RhoGEF PF00621.20 CCF47493.1 - 0.57 10.4 2.5 79 3.4 0.0 4.1 3 1 0 3 3 3 0 RhoGEF domain Glyco_hydro_16 PF00722.21 CCF47494.1 - 1.5e-44 151.6 1.6 3.6e-44 150.4 1.6 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 DUF1080 PF06439.11 CCF47494.1 - 0.028 14.5 0.1 0.042 13.9 0.1 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1080) Macoilin PF09726.9 CCF47494.1 - 7.8 4.9 7.9 9.8 4.6 7.9 1.1 1 0 0 1 1 1 0 Macoilin family MARVEL PF01284.23 CCF47496.1 - 0.0066 16.5 1.5 0.012 15.7 1.5 1.4 1 1 0 1 1 1 1 Membrane-associating domain DUF4231 PF14015.6 CCF47496.1 - 0.09 13.3 2.6 0.16 12.4 0.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF4231) Apq12 PF12716.7 CCF47496.1 - 3 7.9 10.5 0.38 10.7 5.6 2.0 2 0 0 2 2 2 0 Nuclear pore assembly and biogenesis Abhydrolase_2 PF02230.16 CCF47497.1 - 7.4e-24 84.8 0.0 2e-14 54.0 0.0 2.5 2 1 0 2 2 2 2 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 CCF47497.1 - 0.00015 21.3 0.0 0.0004 19.9 0.0 1.6 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 CCF47497.1 - 0.00023 21.8 1.0 0.00034 21.3 1.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family FSH1 PF03959.13 CCF47497.1 - 0.0076 15.9 0.0 0.055 13.1 0.0 2.2 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Sec15 PF04091.12 CCF47499.1 - 8.6e-39 133.8 0.3 9.7e-39 133.6 0.3 1.0 1 0 0 1 1 1 1 Exocyst complex subunit Sec15-like Oxidored_q6 PF01058.22 CCF47500.1 - 1.3e-22 80.0 0.1 1.9e-22 79.5 0.1 1.2 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit adh_short_C2 PF13561.6 CCF47501.1 - 1.1e-16 61.2 0.0 1.2e-16 61.0 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF47501.1 - 0.0015 18.0 0.0 0.0022 17.5 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase Epimerase PF01370.21 CCF47503.1 - 0.00011 21.7 0.0 0.00021 20.8 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Bac_rhamnosid_C PF17390.2 CCF47505.1 - 0.0024 17.6 0.1 0.0054 16.5 0.1 1.6 1 1 0 1 1 1 1 Bacterial alpha-L-rhamnosidase C-terminal domain UPF0160 PF03690.13 CCF47506.1 - 2e-11 44.1 0.1 2.4e-11 43.9 0.1 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) Ino80_Iec3 PF14612.6 CCF47507.1 - 2.6e-13 51.2 2.7 3.3e-13 50.9 2.7 1.2 1 0 0 1 1 1 1 IEC3 subunit of the Ino80 complex, chromatin re-modelling GrpE PF01025.19 CCF47507.1 - 0.056 13.1 1.0 0.06 13.0 1.0 1.1 1 0 0 1 1 1 0 GrpE RasGEF PF00617.19 CCF47508.1 - 9e-50 169.3 0.1 1.4e-49 168.6 0.1 1.3 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 CCF47508.1 - 1.8e-11 44.2 0.0 5.1e-11 42.7 0.0 1.7 1 0 0 1 1 1 1 RasGEF N-terminal motif Ras PF00071.22 CCF47508.1 - 6.7e-07 29.0 1.7 0.00011 21.9 0.0 2.8 3 0 0 3 3 3 2 Ras family RsgA_GTPase PF03193.16 CCF47508.1 - 6.4e-05 22.9 0.0 0.29 11.0 0.1 2.4 2 0 0 2 2 2 2 RsgA GTPase Roc PF08477.13 CCF47508.1 - 0.0079 16.4 0.0 0.94 9.7 0.0 2.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 CCF47508.1 - 0.014 14.9 0.0 0.23 11.0 0.0 2.2 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 CCF47508.1 - 0.033 14.3 0.2 0.15 12.1 0.2 2.1 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_16 PF13191.6 CCF47508.1 - 0.046 14.1 0.0 0.17 12.3 0.0 2.0 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 CCF47508.1 - 0.054 13.8 0.2 1.9 8.7 0.0 2.7 3 0 0 3 3 3 0 AAA domain FtsK_SpoIIIE PF01580.18 CCF47508.1 - 0.12 11.8 0.0 0.28 10.5 0.0 1.6 1 0 0 1 1 1 0 FtsK/SpoIIIE family IIGP PF05049.13 CCF47508.1 - 0.14 11.2 1.9 0.13 11.3 0.1 1.7 2 0 0 2 2 2 0 Interferon-inducible GTPase (IIGP) ATP_bind_1 PF03029.17 CCF47508.1 - 0.15 11.8 0.1 13 5.5 0.0 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein F_bP_aldolase PF01116.20 CCF47511.1 - 1e-49 169.5 0.1 1.1e-49 169.4 0.1 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II Sec7 PF01369.20 CCF47513.1 - 2e-31 109.1 0.1 3.1e-31 108.5 0.1 1.2 1 0 0 1 1 1 1 Sec7 domain Peptidase_M14 PF00246.24 CCF47514.1 - 1.7e-73 247.9 0.0 2.2e-73 247.6 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.16 CCF47514.1 - 0.017 15.5 0.0 0.039 14.3 0.0 1.6 1 0 0 1 1 1 0 Carboxypeptidase activation peptide MAPEG PF01124.18 CCF47515.1 - 4.7e-22 78.3 1.2 5.6e-22 78.0 1.2 1.1 1 0 0 1 1 1 1 MAPEG family DNA_pol_B_thumb PF14791.6 CCF47516.1 - 2.2e-21 75.8 0.0 4.6e-21 74.8 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase beta thumb DNA_pol_B_palm PF14792.6 CCF47516.1 - 2.1e-17 63.4 0.1 4.9e-17 62.2 0.1 1.6 1 1 0 1 1 1 1 DNA polymerase beta palm NTP_transf_2 PF01909.23 CCF47516.1 - 0.0015 18.8 0.3 0.0055 17.0 0.3 1.9 1 1 0 1 1 1 1 Nucleotidyltransferase domain Patched PF02460.18 CCF47518.1 - 7e-28 97.2 11.0 9.1e-28 96.8 11.0 1.0 1 0 0 1 1 1 1 Patched family ACR_tran PF00873.19 CCF47518.1 - 0.0019 16.0 12.5 0.0019 16.0 12.5 1.4 2 0 0 2 2 2 1 AcrB/AcrD/AcrF family MMPL PF03176.15 CCF47518.1 - 0.0045 16.0 13.6 0.0064 15.5 13.6 1.2 1 0 0 1 1 1 1 MMPL family A_deaminase PF00962.22 CCF47521.1 - 4.8e-17 62.3 0.0 5.7e-17 62.0 0.0 1.0 1 0 0 1 1 1 1 Adenosine/AMP deaminase S36_mt PF10937.8 CCF47522.1 - 1.1e-40 139.8 1.3 1.5e-40 139.4 1.3 1.2 1 0 0 1 1 1 1 Ribosomal protein S36, mitochondrial DUF4695 PF15766.5 CCF47522.1 - 0.07 13.3 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4695) SDA1 PF05285.12 CCF47523.1 - 0.00026 20.5 34.1 0.00036 20.1 34.1 1.2 1 0 0 1 1 1 1 SDA1 RNA_pol_Rpc4 PF05132.14 CCF47523.1 - 0.033 14.6 0.4 0.069 13.6 0.4 1.5 1 0 0 1 1 1 0 RNA polymerase III RPC4 Apt1 PF10351.9 CCF47523.1 - 0.16 10.8 3.0 0.27 10.1 3.0 1.4 1 0 0 1 1 1 0 Golgi-body localisation protein domain SAPS PF04499.15 CCF47523.1 - 2.1 7.1 6.7 2.2 7.0 6.7 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Nop14 PF04147.12 CCF47523.1 - 2.6 6.2 36.5 3.2 5.8 36.5 1.1 1 0 0 1 1 1 0 Nop14-like family DUF913 PF06025.12 CCF47523.1 - 3.2 6.6 4.4 4.6 6.1 4.4 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) SpoIIIAH PF12685.7 CCF47523.1 - 6.7 6.5 10.0 10 5.9 10.0 1.4 1 0 0 1 1 1 0 SpoIIIAH-like protein Lectin_N PF03954.14 CCF47524.1 - 0.011 15.5 0.0 0.015 15.1 0.0 1.2 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain IBR PF01485.21 CCF47525.1 - 1e-08 35.3 41.8 5.8e-07 29.6 13.9 3.5 3 1 0 3 3 3 2 IBR domain, a half RING-finger domain zf-RING_2 PF13639.6 CCF47525.1 - 0.0032 17.7 7.7 0.0032 17.7 7.7 3.5 3 0 0 3 3 3 1 Ring finger domain FAA_hydrolase PF01557.18 CCF47526.1 - 1.5e-63 214.4 0.0 1.8e-63 214.1 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Complex1_LYR PF05347.15 CCF47527.1 - 1.5e-15 57.0 1.3 1.9e-15 56.7 1.3 1.1 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 CCF47527.1 - 1.5e-06 28.9 0.2 1.9e-06 28.6 0.2 1.2 1 0 0 1 1 1 1 Complex1_LYR-like RRM_1 PF00076.22 CCF47532.1 - 7.4e-12 44.9 0.0 1.3e-11 44.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CCF47532.1 - 2.7e-05 23.7 0.0 5.3e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 CCF47532.1 - 0.019 15.0 0.1 0.036 14.1 0.1 1.4 1 0 0 1 1 1 0 RNA binding motif RRM_occluded PF16842.5 CCF47532.1 - 0.052 13.4 0.0 0.099 12.5 0.0 1.4 1 0 0 1 1 1 0 Occluded RNA-recognition motif Ribonuc_L-PSP PF01042.21 CCF47533.1 - 7.3e-35 119.6 0.0 8.3e-35 119.4 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP NACHT PF05729.12 CCF47534.1 - 1.6e-07 31.4 0.1 4e-07 30.1 0.1 1.6 1 0 0 1 1 1 1 NACHT domain PNP_UDP_1 PF01048.20 CCF47534.1 - 4.5e-07 29.4 0.0 9.6e-07 28.3 0.0 1.6 1 1 0 1 1 1 1 Phosphorylase superfamily AAA_22 PF13401.6 CCF47534.1 - 6.7e-06 26.4 0.1 0.00027 21.2 0.1 2.8 2 1 0 2 2 2 1 AAA domain AAA PF00004.29 CCF47534.1 - 0.00036 21.0 1.5 0.0029 18.0 1.5 2.2 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CCF47534.1 - 0.0021 18.5 0.1 0.013 15.9 0.0 2.4 2 1 0 2 2 2 1 AAA ATPase domain ABC_tran PF00005.27 CCF47534.1 - 0.03 14.8 0.0 0.061 13.8 0.0 1.6 1 0 0 1 1 1 0 ABC transporter RNA_helicase PF00910.22 CCF47534.1 - 0.073 13.5 0.1 0.18 12.2 0.1 1.7 1 0 0 1 1 1 0 RNA helicase Rad17 PF03215.15 CCF47534.1 - 0.082 12.8 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain Ploopntkinase3 PF18751.1 CCF47534.1 - 0.092 12.6 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 AAA_29 PF13555.6 CCF47534.1 - 0.11 12.2 0.0 0.27 11.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_18 PF13238.6 CCF47534.1 - 0.16 12.6 3.3 0.22 12.1 0.0 2.6 2 0 0 2 2 2 0 AAA domain DUF4692 PF15763.5 CCF47534.1 - 1.2 9.6 4.4 2.1 8.8 4.4 1.4 1 0 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) AAA_23 PF13476.6 CCF47534.1 - 6.4 7.2 9.5 1.9 9.0 0.0 2.8 2 1 0 3 3 3 0 AAA domain Ank_2 PF12796.7 CCF47535.1 - 1.2e-11 45.1 0.1 1.6e-11 44.7 0.1 1.2 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CCF47535.1 - 9.7e-10 38.8 1.0 7.3e-05 23.2 0.1 2.2 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 CCF47535.1 - 2.3e-05 24.7 0.0 0.96 10.0 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 CCF47535.1 - 3.5e-05 23.9 0.1 0.051 14.1 0.1 3.2 3 0 0 3 3 3 1 Ankyrin repeat Ank_5 PF13857.6 CCF47535.1 - 8.2e-05 22.8 0.6 0.0017 18.6 0.6 2.3 1 1 1 2 2 2 1 Ankyrin repeats (many copies) RSRP PF17069.5 CCF47536.1 - 5.8 6.4 22.6 6 6.4 22.6 1.0 1 0 0 1 1 1 0 Arginine/Serine-Rich protein 1 PAP2 PF01569.21 CCF47537.1 - 2.6e-13 49.9 0.1 2.6e-13 49.9 0.1 2.0 3 0 0 3 3 3 1 PAP2 superfamily PAP2_3 PF14378.6 CCF47537.1 - 0.0059 16.3 1.2 0.012 15.3 1.2 1.6 1 1 0 1 1 1 1 PAP2 superfamily DUF4452 PF14618.6 CCF47539.1 - 1.2e-81 272.6 11.4 1.4e-81 272.4 11.4 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4452) HTH_Tnp_Tc5 PF03221.16 CCF47544.1 - 0.04 13.9 0.0 0.12 12.4 0.0 1.8 2 0 0 2 2 2 0 Tc5 transposase DNA-binding domain BIR PF00653.21 CCF47544.1 - 0.054 14.1 0.2 0.12 13.0 0.2 1.6 1 0 0 1 1 1 0 Inhibitor of Apoptosis domain MFS_1 PF07690.16 CCF47545.1 - 3.1e-25 88.9 26.7 3.7e-25 88.6 26.7 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Phage_holin_5_1 PF06946.11 CCF47545.1 - 0.4 11.1 0.1 0.4 11.1 0.1 2.1 2 0 0 2 2 2 0 Bacteriophage A118-like holin, Hol118 Vps55 PF04133.14 CCF47550.1 - 1e-45 154.4 8.1 1.2e-45 154.3 8.1 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting 55 LVIVD PF08309.11 CCF47552.1 - 0.14 11.5 0.1 2.8 7.3 0.0 2.7 2 0 0 2 2 2 0 LVIVD repeat PP1_bind PF15276.6 CCF47554.1 - 0.00023 21.4 15.6 0.087 13.2 0.6 3.3 2 1 1 3 3 3 3 Protein phosphatase 1 binding Spo12 PF05032.12 CCF47555.1 - 5.2e-15 55.1 0.7 5.2e-15 55.1 0.7 2.3 2 0 0 2 2 2 1 Spo12 family Nup214_FG PF18617.1 CCF47555.1 - 0.039 14.5 1.0 0.057 14.0 1.0 1.3 1 0 0 1 1 1 0 Nucleoporin Nup214 phenylalanine-glycine (FG) domain Peptidase_S8_N PF16361.5 CCF47555.1 - 0.13 12.8 0.9 0.2 12.2 0.9 1.3 1 0 0 1 1 1 0 N-terminal of Subtilase family Peptidase_M24 PF00557.24 CCF47556.1 - 5.3e-08 32.8 0.0 6.3e-08 32.6 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Methyltransf_23 PF13489.6 CCF47560.1 - 0.00032 20.6 0.0 0.00049 20.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF47560.1 - 0.0029 18.3 0.0 0.0046 17.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF47560.1 - 0.027 15.1 0.0 0.089 13.5 0.0 1.9 3 0 0 3 3 3 0 Methyltransferase domain CheR PF01739.18 CCF47560.1 - 0.096 12.2 0.0 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain Abhydrolase_6 PF12697.7 CCF47562.1 - 9.7e-06 26.3 0.9 1.2e-05 26.1 0.9 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF676 PF05057.14 CCF47562.1 - 0.0011 18.6 0.0 0.0023 17.5 0.0 1.6 1 1 0 1 1 1 1 Putative serine esterase (DUF676) Hydrolase_4 PF12146.8 CCF47562.1 - 0.0019 17.5 0.0 0.034 13.4 0.0 2.2 2 0 0 2 2 2 1 Serine aminopeptidase, S33 PGAP1 PF07819.13 CCF47562.1 - 0.002 17.9 0.0 0.0033 17.2 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Esterase PF00756.20 CCF47562.1 - 0.035 13.7 0.0 0.089 12.4 0.0 1.6 2 0 0 2 2 2 0 Putative esterase Abhydrolase_2 PF02230.16 CCF47562.1 - 0.061 13.1 0.0 0.22 11.3 0.0 1.7 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Abhydrolase_3 PF07859.13 CCF47562.1 - 0.12 12.2 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Thioesterase PF00975.20 CCF47562.1 - 0.15 12.2 0.0 0.24 11.5 0.0 1.3 1 0 0 1 1 1 0 Thioesterase domain Abhydrolase_5 PF12695.7 CCF47562.1 - 0.15 11.8 0.0 0.26 11.0 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Lipase_3 PF01764.25 CCF47562.1 - 0.16 11.8 0.0 0.25 11.2 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) UDPG_MGDP_dh_N PF03721.14 CCF47563.1 - 3.3e-15 56.1 1.1 3.6e-12 46.2 1.1 2.1 1 1 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_2 PF03446.15 CCF47563.1 - 2.3e-06 27.9 0.0 2.8e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase TrkA_N PF02254.18 CCF47563.1 - 0.0049 17.1 0.0 0.0081 16.4 0.0 1.4 1 0 0 1 1 1 1 TrkA-N domain 3HCDH_N PF02737.18 CCF47563.1 - 0.075 12.9 0.0 0.09 12.7 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Methyltransf_25 PF13649.6 CCF47563.1 - 0.1 13.3 0.0 0.15 12.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain DUF1685 PF07939.11 CCF47565.1 - 0.12 12.2 0.3 2 8.2 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1685) Ion_trans PF00520.31 CCF47567.1 - 5.3e-05 22.6 10.5 5.3e-05 22.6 10.5 1.5 2 0 0 2 2 2 1 Ion transport protein PKD_channel PF08016.12 CCF47567.1 - 0.61 8.7 9.9 1.5 7.4 1.1 2.2 1 1 0 2 2 2 0 Polycystin cation channel DUF997 PF06196.12 CCF47567.1 - 2.6 8.1 9.0 1.3 9.1 5.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF997) DUF1961 PF09224.11 CCF47568.1 - 5.9e-102 339.6 0.0 6.7e-102 339.4 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1961) DUF1080 PF06439.11 CCF47568.1 - 0.026 14.7 0.0 0.03 14.4 0.0 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1080) Peroxidase_2 PF01328.17 CCF47569.1 - 2.9e-51 174.7 0.1 3.7e-51 174.3 0.1 1.1 1 0 0 1 1 1 1 Peroxidase, family 2 HMG-CoA_red PF00368.18 CCF47574.1 - 3.3e-115 385.0 9.4 3.8e-115 384.8 9.4 1.0 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase Anoctamin PF04547.12 CCF47575.1 - 3.7e-101 339.2 2.5 4.2e-101 339.0 2.5 1.0 1 0 0 1 1 1 1 Calcium-activated chloride channel DUF3671 PF12420.8 CCF47575.1 - 0.34 11.0 6.1 6 7.0 0.2 2.8 2 1 0 2 2 2 0 Protein of unknown function Peptidase_M35 PF02102.15 CCF47576.1 - 6.4e-61 206.2 1.0 7.8e-61 205.9 1.0 1.0 1 0 0 1 1 1 1 Deuterolysin metalloprotease (M35) family Aspzincin_M35 PF14521.6 CCF47576.1 - 1.4e-39 135.9 0.2 2.2e-39 135.3 0.2 1.2 1 0 0 1 1 1 1 Lysine-specific metallo-endopeptidase DUF3762 PF12591.8 CCF47576.1 - 0.1 12.9 0.6 0.22 11.8 0.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3762) Ribonuc_2-5A PF06479.12 CCF47578.1 - 1.5e-43 148.0 0.0 3.1e-43 147.0 0.0 1.6 1 0 0 1 1 1 1 Ribonuclease 2-5A Pkinase PF00069.25 CCF47578.1 - 2.7e-40 138.4 0.0 7.2e-30 104.2 0.0 2.5 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCF47578.1 - 4.5e-20 72.0 0.0 9.8e-19 67.6 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CCF47578.1 - 0.0018 17.7 0.0 0.0018 17.7 0.0 1.9 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 CCF47578.1 - 0.0067 15.2 1.1 0.0083 14.9 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 CCF47578.1 - 0.054 13.4 6.8 0.051 13.5 0.3 2.9 2 1 0 2 2 2 0 Phosphotransferase enzyme family PQQ PF01011.21 CCF47578.1 - 0.085 12.8 0.2 7.8 6.6 0.1 2.9 2 0 0 2 2 2 0 PQQ enzyme repeat Fasciclin PF02469.22 CCF47579.1 - 1.3e-10 41.5 1.5 1.3e-10 41.5 1.5 1.5 1 1 1 2 2 2 1 Fasciclin domain GerD PF17898.1 CCF47579.1 - 0.027 14.4 0.2 0.061 13.3 0.1 1.6 1 1 0 1 1 1 0 Spore germination GerD central core domain MIF4G PF02854.19 CCF47579.1 - 0.16 11.6 0.0 2.5 7.7 0.0 2.0 1 1 1 2 2 2 0 MIF4G domain UBX PF00789.20 CCF47580.1 - 8.1e-13 48.4 0.0 1.2e-12 47.9 0.0 1.2 1 0 0 1 1 1 1 UBX domain CHCH PF06747.13 CCF47581.1 - 0.00018 21.5 5.1 0.00026 21.0 5.1 1.3 1 0 0 1 1 1 1 CHCH domain Trypan_glycop_C PF10659.9 CCF47581.1 - 0.0054 17.1 2.5 0.0069 16.7 2.5 1.1 1 0 0 1 1 1 1 Trypanosome variant surface glycoprotein C-terminal domain Romo1 PF10247.9 CCF47581.1 - 0.013 15.8 0.0 0.02 15.2 0.0 1.3 1 0 0 1 1 1 0 Reactive mitochondrial oxygen species modulator 1 GCK PF07802.11 CCF47581.1 - 0.051 14.0 0.6 0.12 12.8 0.6 1.7 1 1 0 1 1 1 0 GCK domain COX17 PF05051.13 CCF47581.1 - 0.31 11.4 1.8 0.62 10.5 0.2 2.0 1 1 1 2 2 2 0 Cytochrome C oxidase copper chaperone (COX17) CX9C PF16860.5 CCF47581.1 - 2 8.5 6.1 0.77 9.8 1.0 1.8 1 1 1 2 2 2 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Atrophin-1 PF03154.15 CCF47582.1 - 1.6 6.9 7.0 1.4 7.1 7.0 1.1 1 0 0 1 1 1 0 Atrophin-1 family XRN1_D1 PF18332.1 CCF47584.1 - 5.7e-62 208.9 0.0 1.1e-61 207.9 0.0 1.5 2 0 0 2 2 2 1 Exoribonuclease Xrn1 D1 domain XRN_M PF17846.1 CCF47584.1 - 1.4e-21 77.0 0.0 2e-21 76.5 0.0 1.4 1 0 0 1 1 1 1 Xrn1 helical domain p450 PF00067.22 CCF47585.1 - 9.4e-37 126.8 0.0 1e-36 126.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 NmrA PF05368.13 CCF47586.1 - 4.9e-15 55.7 0.0 7.2e-15 55.2 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CCF47586.1 - 7.1e-13 48.8 0.0 1e-12 48.4 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 CCF47586.1 - 1.1e-06 28.9 0.0 1.8e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.21 CCF47586.1 - 6.9e-05 22.4 0.2 9.9e-05 21.9 0.2 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DapB_N PF01113.20 CCF47586.1 - 0.00027 21.1 0.5 0.0008 19.5 0.5 1.8 2 1 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus ApbA PF02558.16 CCF47586.1 - 0.017 14.7 0.1 0.027 14.1 0.1 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA adh_short PF00106.25 CCF47586.1 - 0.085 12.3 0.2 0.12 11.8 0.2 1.3 1 0 0 1 1 1 0 short chain dehydrogenase KR PF08659.10 CCF47586.1 - 0.097 12.6 0.1 0.16 11.9 0.1 1.4 1 0 0 1 1 1 0 KR domain Methyltransf_23 PF13489.6 CCF47587.1 - 2.1e-22 79.7 0.0 3.4e-22 79.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF47587.1 - 2e-11 44.4 0.0 5.9e-11 42.9 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF47587.1 - 4.2e-11 42.9 0.0 9.1e-11 41.8 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF47587.1 - 7.3e-08 33.1 0.0 2.8e-07 31.2 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF47587.1 - 1.3e-07 32.2 0.0 2.4e-07 31.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 CCF47587.1 - 0.00067 19.2 0.0 0.0071 15.8 0.0 2.1 2 0 0 2 2 2 1 Putative methyltransferase MTS PF05175.14 CCF47587.1 - 0.009 15.6 0.0 0.017 14.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_16 PF10294.9 CCF47587.1 - 0.032 14.0 0.0 0.054 13.2 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase FtsJ PF01728.19 CCF47587.1 - 0.17 12.0 0.0 0.24 11.5 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase Aldo_ket_red PF00248.21 CCF47588.1 - 4.1e-37 128.0 0.0 3.4e-27 95.4 0.0 2.0 1 1 1 2 2 2 2 Aldo/keto reductase family eRF1_1 PF03463.15 CCF47589.1 - 2.5e-43 147.1 0.0 4.6e-43 146.3 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 1 eRF1_2 PF03464.15 CCF47589.1 - 9.5e-19 68.0 0.1 1.6e-18 67.3 0.1 1.4 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 CCF47589.1 - 1.6e-16 60.8 0.0 2.9e-16 59.9 0.0 1.5 1 0 0 1 1 1 1 eRF1 domain 3 WD40 PF00400.32 CCF47590.1 - 1.3e-26 92.3 17.6 2.3e-06 28.2 0.4 7.3 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF47590.1 - 1.6e-06 28.3 0.6 0.29 11.5 0.0 5.5 1 1 5 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CCF47590.1 - 0.0001 21.4 3.7 0.0031 16.5 0.2 3.3 2 1 0 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nudix_N_2 PF14803.6 CCF47590.1 - 0.43 10.6 1.5 1.2 9.1 1.5 1.8 1 0 0 1 1 1 0 Nudix N-terminal Dicty_REP PF05086.12 CCF47590.1 - 1.5 6.7 7.0 0.33 8.9 3.7 1.5 1 1 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Thioredoxin PF00085.20 CCF47591.1 - 7.7e-23 80.4 0.0 1.3e-22 79.7 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 CCF47591.1 - 1.5e-06 28.6 0.3 4.9e-06 26.9 0.1 1.9 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 CCF47591.1 - 1.5e-05 25.2 0.0 0.00013 22.2 0.0 1.9 1 1 0 1 1 1 1 Thioredoxin-like OST3_OST6 PF04756.13 CCF47591.1 - 3.8e-05 23.2 0.0 4.2e-05 23.0 0.0 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family TraF PF13728.6 CCF47591.1 - 0.0028 17.5 1.4 0.0064 16.3 0.0 1.9 2 0 0 2 2 2 1 F plasmid transfer operon protein Thioredoxin_7 PF13899.6 CCF47591.1 - 0.0046 17.1 0.0 0.0046 17.1 0.0 1.8 2 0 0 2 2 2 1 Thioredoxin-like AhpC-TSA PF00578.21 CCF47591.1 - 0.0046 16.9 0.4 0.17 11.8 0.1 2.2 1 1 1 2 2 2 1 AhpC/TSA family Redoxin PF08534.10 CCF47591.1 - 0.024 14.4 0.6 0.5 10.1 0.1 2.2 1 1 0 2 2 2 0 Redoxin HyaE PF07449.11 CCF47591.1 - 0.13 12.2 0.0 0.3 11.1 0.0 1.6 2 0 0 2 2 2 0 Hydrogenase-1 expression protein HyaE Amidoligase_2 PF12224.8 CCF47592.1 - 6e-11 42.5 0.0 6.3e-08 32.6 0.0 2.5 1 1 1 2 2 2 2 Putative amidoligase enzyme IDO PF01231.18 CCF47593.1 - 2.6e-82 276.9 0.0 3e-82 276.7 0.0 1.0 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase DUF1864 PF08933.11 CCF47593.1 - 0.0018 17.1 0.0 0.003 16.4 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1864) Methyltransf_23 PF13489.6 CCF47597.1 - 3.8e-23 82.1 0.0 5.6e-23 81.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF47597.1 - 1.4e-11 44.9 0.0 4.7e-11 43.2 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF47597.1 - 5.8e-10 39.2 0.0 8.9e-09 35.3 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF47597.1 - 2.2e-09 37.9 0.0 3.9e-09 37.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF47597.1 - 4.6e-06 27.3 0.0 4.7e-05 24.1 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CCF47597.1 - 0.00033 20.3 0.0 0.00053 19.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_2 PF00891.18 CCF47597.1 - 0.003 16.9 0.0 0.14 11.4 0.0 2.4 3 0 0 3 3 3 1 O-methyltransferase domain PrmA PF06325.13 CCF47597.1 - 0.0036 16.8 0.0 0.0057 16.1 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) DUF938 PF06080.12 CCF47597.1 - 0.066 13.0 0.0 0.1 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Ubie_methyltran PF01209.18 CCF47597.1 - 0.073 12.4 0.0 0.79 9.0 0.0 2.3 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_16 PF10294.9 CCF47597.1 - 0.085 12.6 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 Lysine methyltransferase CMAS PF02353.20 CCF47597.1 - 0.099 11.9 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_4 PF02390.17 CCF47597.1 - 0.14 11.7 0.0 0.68 9.4 0.0 1.9 2 0 0 2 2 2 0 Putative methyltransferase Chitin_bind_1 PF00187.19 CCF47599.1 - 7.4e-15 55.1 46.2 1.6e-07 31.7 20.3 2.9 2 0 0 2 2 2 2 Chitin recognition protein ABC_tran PF00005.27 CCF47600.1 - 6.1e-08 33.3 0.1 2.8e-07 31.1 0.0 1.9 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.19 CCF47600.1 - 0.028 13.9 0.0 0.046 13.1 0.0 1.3 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain ABC2_membrane PF01061.24 CCF47600.1 - 0.15 11.5 0.0 0.22 10.9 0.0 1.2 1 0 0 1 1 1 0 ABC-2 type transporter GAIN_A PF18619.1 CCF47600.1 - 0.65 10.2 0.0 0.65 10.2 0.0 2.3 3 0 0 3 3 3 0 GPCR-Autoproteolysis-INducing (GAIN) subdomain A UDPGT PF00201.18 CCF47601.1 - 4.7e-05 22.4 0.0 5.1e-05 22.3 0.0 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase UMP1 PF05348.11 CCF47602.1 - 3.2e-28 98.3 0.1 3.5e-28 98.2 0.1 1.0 1 0 0 1 1 1 1 Proteasome maturation factor UMP1 Rad60-SLD_2 PF13881.6 CCF47603.1 - 0.015 15.4 0.0 0.015 15.4 0.0 1.1 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 CCF47603.1 - 0.065 13.0 0.0 0.077 12.8 0.0 1.1 1 0 0 1 1 1 0 Ubiquitin family Glyco_hydro_43 PF04616.14 CCF47604.1 - 2.2e-51 174.9 0.9 2.6e-51 174.7 0.9 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 GFA PF04828.14 CCF47605.1 - 1.2e-20 73.6 0.6 1.8e-20 73.1 0.6 1.2 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme adh_short_C2 PF13561.6 CCF47607.1 - 1.5e-55 188.3 0.4 2e-55 187.9 0.4 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF47607.1 - 1.3e-46 158.6 0.9 1.5e-46 158.3 0.9 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF47607.1 - 4.8e-13 49.4 0.6 6.5e-13 49.0 0.6 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF47607.1 - 0.00011 21.8 0.2 0.00019 21.0 0.2 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CCF47607.1 - 0.018 14.4 0.0 0.077 12.4 0.0 1.8 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase NusB PF01029.18 CCF47607.1 - 0.08 13.2 0.0 0.14 12.4 0.0 1.3 1 0 0 1 1 1 0 NusB family DUF3235 PF11574.8 CCF47608.1 - 0.29 12.0 4.3 0.6 11.0 4.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3235) PAS_3 PF08447.12 CCF47612.1 - 3.9e-09 36.7 0.0 4.6e-09 36.4 0.0 1.1 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.7 CCF47612.1 - 2.2e-07 31.0 0.0 2.4e-07 30.9 0.0 1.1 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 CCF47612.1 - 4.6e-06 26.6 0.0 5.7e-06 26.3 0.0 1.1 1 0 0 1 1 1 1 PAS fold PAS_11 PF14598.6 CCF47612.1 - 0.00074 19.6 0.0 0.00075 19.6 0.0 1.1 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.10 CCF47612.1 - 0.024 14.9 0.0 0.026 14.8 0.0 1.1 1 0 0 1 1 1 0 PAS fold Peptidase_M35 PF02102.15 CCF47614.1 - 0.04 12.8 0.1 0.04 12.8 0.1 1.0 1 0 0 1 1 1 0 Deuterolysin metalloprotease (M35) family Glyco_hydro_35 PF01301.19 CCF47615.1 - 4.1e-59 200.8 0.0 4.6e-59 200.6 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 Amidohydro_1 PF01979.20 CCF47616.1 - 2.4e-13 50.1 0.0 9.6e-13 48.2 0.0 1.9 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 CCF47616.1 - 1.7e-05 24.5 0.1 6.8e-05 22.5 0.0 1.9 2 0 0 2 2 2 1 Amidohydrolase family Mid2 PF04478.12 CCF47617.1 - 3.7e-06 26.8 0.6 3.7e-06 26.8 0.6 2.6 2 1 0 3 3 3 1 Mid2 like cell wall stress sensor MAP17 PF15807.5 CCF47617.1 - 0.087 13.1 0.0 0.29 11.4 0.0 1.8 2 0 0 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 TPR_21 PF09976.9 CCF47617.1 - 0.2 11.4 0.1 0.2 11.4 0.1 1.6 2 0 0 2 2 2 0 Tetratricopeptide repeat-like domain FeoB_associated PF12669.7 CCF47617.1 - 0.28 11.6 0.4 0.5 10.8 0.4 1.4 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein Plasmodium_Vir PF05795.11 CCF47617.1 - 0.62 9.4 7.5 0.88 8.9 7.5 1.3 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Utp14 PF04615.13 CCF47617.1 - 0.74 8.3 4.6 0.81 8.2 4.6 1.1 1 0 0 1 1 1 0 Utp14 protein TFIIA PF03153.13 CCF47617.1 - 1.6 8.6 12.6 2.1 8.2 12.6 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit TATR PF03430.13 CCF47621.1 - 0.082 11.3 0.0 0.12 10.8 0.0 1.1 1 0 0 1 1 1 0 Trans-activating transcriptional regulator L51_S25_CI-B8 PF05047.16 CCF47622.1 - 4.1e-12 45.8 0.0 5.2e-12 45.5 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain CaM_binding PF07839.11 CCF47622.1 - 0.12 13.2 0.0 0.13 13.0 0.0 1.1 1 0 0 1 1 1 0 Plant calmodulin-binding domain Glyco_hydro_47 PF01532.20 CCF47624.1 - 9.7e-142 473.1 0.0 1.1e-141 472.9 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 KR PF08659.10 CCF47625.1 - 3.4e-56 190.0 0.1 2.2e-55 187.4 0.0 2.4 2 0 0 2 2 2 1 KR domain PS-DH PF14765.6 CCF47625.1 - 6.6e-52 176.6 0.0 1.4e-51 175.6 0.0 1.6 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 CCF47625.1 - 3.5e-45 154.9 0.1 5.3e-45 154.3 0.1 1.3 1 0 0 1 1 1 1 Acyl transferase domain Methyltransf_12 PF08242.12 CCF47625.1 - 9e-23 80.9 0.0 5e-22 78.5 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain ADH_zinc_N_2 PF13602.6 CCF47625.1 - 1.7e-19 71.2 0.0 3.1e-17 63.9 0.0 3.0 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 CCF47625.1 - 7e-17 61.6 0.7 1.8e-15 57.1 0.0 3.3 3 0 0 3 3 3 1 Zinc-binding dehydrogenase Methyltransf_25 PF13649.6 CCF47625.1 - 9.9e-15 55.0 0.0 5e-14 52.8 0.0 2.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF47625.1 - 1.5e-12 47.7 0.0 3e-12 46.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF47625.1 - 3.5e-12 46.4 0.0 9.4e-12 45.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF47625.1 - 1.4e-11 44.9 0.0 5.8e-11 42.9 0.0 2.2 1 0 0 1 1 1 1 Methyltransferase domain PP-binding PF00550.25 CCF47625.1 - 2.3e-08 34.2 0.1 1.1e-07 32.1 0.0 2.3 2 0 0 2 2 1 1 Phosphopantetheine attachment site adh_short PF00106.25 CCF47625.1 - 2.8e-08 33.5 0.2 1.1e-06 28.3 0.0 2.7 2 0 0 2 2 2 1 short chain dehydrogenase Ubie_methyltran PF01209.18 CCF47625.1 - 1e-05 25.0 0.0 2.4e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family adh_short_C2 PF13561.6 CCF47625.1 - 3.2e-05 23.6 0.6 0.00026 20.6 0.0 2.5 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase ADH_N PF08240.12 CCF47625.1 - 0.00016 21.6 2.5 0.00031 20.6 0.0 2.7 3 0 0 3 3 3 1 Alcohol dehydrogenase GroES-like domain DUF938 PF06080.12 CCF47625.1 - 0.00036 20.3 0.0 0.0011 18.8 0.0 1.7 2 0 0 2 2 1 1 Protein of unknown function (DUF938) Methyltransf_28 PF02636.17 CCF47625.1 - 0.0057 16.3 0.0 0.015 14.9 0.0 1.6 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_24 PF13578.6 CCF47625.1 - 0.0079 17.2 0.0 0.074 14.1 0.0 2.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_33 PF10017.9 CCF47625.1 - 0.01 15.0 0.0 0.023 13.8 0.0 1.5 1 0 0 1 1 1 1 Histidine-specific methyltransferase, SAM-dependent Methyltransf_16 PF10294.9 CCF47625.1 - 0.02 14.6 0.0 0.13 12.0 0.0 2.1 2 0 0 2 2 2 0 Lysine methyltransferase DREV PF05219.12 CCF47625.1 - 0.02 14.0 0.0 0.04 13.0 0.0 1.4 1 0 0 1 1 1 0 DREV methyltransferase Peptidase_M55 PF04951.13 CCF47625.1 - 0.057 12.8 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 D-aminopeptidase PALP PF00291.25 CCF47625.1 - 0.14 11.5 2.2 0.7 9.2 0.2 2.9 3 0 0 3 3 3 0 Pyridoxal-phosphate dependent enzyme DUF915 PF06028.11 CCF47625.1 - 0.2 10.9 0.0 0.35 10.2 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) DUF824 PF05688.11 CCF47628.1 - 0.041 13.7 0.0 0.075 12.9 0.0 1.5 2 0 0 2 2 2 0 Salmonella repeat of unknown function (DUF824) PUCC PF03209.15 CCF47629.1 - 0.00098 18.2 7.8 0.013 14.5 4.6 2.0 1 1 1 2 2 2 2 PUCC protein MFS_1 PF07690.16 CCF47629.1 - 0.0098 14.8 6.8 0.0098 14.8 6.8 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily UxuA PF03786.13 CCF47629.1 - 0.042 12.7 0.0 0.05 12.4 0.0 1.0 1 0 0 1 1 1 0 D-mannonate dehydratase (UxuA) p450 PF00067.22 CCF47631.1 - 7.4e-22 77.7 0.0 8.8e-22 77.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Mg_trans_NIPA PF05653.14 CCF47634.1 - 3.3e-96 321.9 14.2 3.8e-96 321.7 14.2 1.0 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 CCF47634.1 - 0.0001 22.5 7.0 0.0001 22.5 7.0 3.0 3 1 0 3 3 3 1 EamA-like transporter family Transmemb_17 PF09799.9 CCF47634.1 - 9 6.9 11.4 2.4 8.8 2.7 2.7 1 1 0 2 2 2 0 Predicted membrane protein Ribosomal_S3_C PF00189.20 CCF47635.1 - 9.8e-25 86.9 0.2 5.5e-24 84.5 0.1 2.1 2 0 0 2 2 2 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.17 CCF47635.1 - 6.6e-12 45.1 0.1 1.1e-11 44.3 0.1 1.4 1 0 0 1 1 1 1 KH domain Coilin_N PF15862.5 CCF47635.1 - 0.023 14.5 0.3 0.33 10.8 0.0 2.1 2 0 0 2 2 2 0 Coilin N-terminus UN_NPL4 PF11543.8 CCF47635.1 - 0.099 13.1 0.0 0.2 12.2 0.0 1.5 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 Myotub-related PF06602.14 CCF47636.1 - 2e-150 500.6 0.2 2.4e-150 500.3 0.2 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Y_phosphatase3 PF13350.6 CCF47636.1 - 0.095 12.7 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 Tyrosine phosphatase family Y_phosphatase PF00102.27 CCF47636.1 - 0.1 12.2 0.0 0.22 11.1 0.0 1.5 1 1 0 1 1 1 0 Protein-tyrosine phosphatase HTH_Tnp_Tc5 PF03221.16 CCF47638.1 - 0.11 12.6 0.0 0.14 12.3 0.0 1.2 1 0 0 1 1 1 0 Tc5 transposase DNA-binding domain Pectate_lyase_3 PF12708.7 CCF47641.1 - 1.2e-33 116.8 10.5 2.4e-28 99.5 1.4 3.3 2 1 2 4 4 4 3 Pectate lyase superfamily protein NosD PF05048.13 CCF47641.1 - 0.026 13.8 6.3 0.04 13.2 6.3 1.3 1 0 0 1 1 1 0 Periplasmic copper-binding protein (NosD) ELYS PF13934.6 CCF47642.1 - 1.4e-69 234.4 2.0 1.7e-69 234.2 2.0 1.0 1 0 0 1 1 1 1 Nuclear pore complex assembly NADPH_Ox PF08414.10 CCF47642.1 - 0.094 13.1 0.0 34 4.8 0.0 3.2 2 1 1 3 3 3 0 Respiratory burst NADPH oxidase OPT PF03169.15 CCF47644.1 - 5.2e-77 259.9 26.9 5.9e-77 259.7 26.9 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein PocR PF10114.9 CCF47644.1 - 0.29 10.9 0.4 0.59 9.9 0.0 1.7 2 0 0 2 2 2 0 Sensory domain found in PocR DUF4407 PF14362.6 CCF47644.1 - 6.9 5.9 5.6 35 3.6 2.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Hemerythrin PF01814.23 CCF47645.1 - 2.2e-10 41.3 1.3 2.8e-10 40.9 1.3 1.1 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain DUF4210 PF13915.6 CCF47646.1 - 7.2e-33 113.0 0.1 1.9e-32 111.6 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4210) Chromosome_seg PF13889.6 CCF47646.1 - 5.9e-23 80.8 0.6 1.2e-22 79.8 0.6 1.6 1 0 0 1 1 1 1 Chromosome segregation during meiosis Nup35_RRM_2 PF14605.6 CCF47647.1 - 1.5e-08 34.5 0.1 0.0033 17.4 0.1 2.4 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif PWI PF01480.17 CCF47647.1 - 1.8e-07 31.3 0.0 5.4e-07 29.8 0.0 1.8 2 0 0 2 2 2 1 PWI domain RRM_1 PF00076.22 CCF47647.1 - 4.8e-07 29.5 0.2 3.5e-06 26.7 0.1 2.3 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH PF00642.24 CCF47647.1 - 9e-06 25.5 3.0 1.7e-05 24.6 3.0 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 CCF47647.1 - 0.00017 21.6 4.6 0.00032 20.7 4.6 1.5 1 0 0 1 1 1 1 Zinc finger domain Borrelia_P83 PF05262.11 CCF47647.1 - 0.0014 17.2 5.7 0.0019 16.7 5.7 1.2 1 0 0 1 1 1 1 Borrelia P83/100 protein PHM7_cyt PF14703.6 CCF47647.1 - 0.015 15.6 3.8 0.032 14.5 0.0 2.6 2 0 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter RRM_3 PF08777.11 CCF47647.1 - 0.025 14.6 8.3 2.3 8.3 6.1 3.2 2 1 1 3 3 3 0 RNA binding motif Seryl_tRNA_N PF02403.22 CCF47647.1 - 0.12 12.7 11.2 0.28 11.4 11.2 1.6 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Torus PF16131.5 CCF47647.1 - 0.18 12.5 0.3 0.18 12.5 0.3 2.1 2 0 0 2 2 2 0 Torus domain DUF5542 PF17696.1 CCF47647.1 - 0.21 11.7 2.4 1.3 9.2 2.4 2.4 1 0 0 1 1 1 0 Family of unknown function (DUF5542) zf-CCCH_4 PF18044.1 CCF47647.1 - 0.41 10.5 4.6 0.68 9.8 4.6 1.3 1 0 0 1 1 1 0 CCCH-type zinc finger HSP70 PF00012.20 CCF47647.1 - 4.1 5.5 8.0 6.1 4.9 8.0 1.1 1 0 0 1 1 1 0 Hsp70 protein EFG_IV PF03764.18 CCF47648.1 - 1.2e-32 112.3 0.0 3.1e-32 110.9 0.0 1.7 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.24 CCF47648.1 - 4.8e-23 81.0 0.0 1.7e-22 79.2 0.0 1.9 2 0 0 2 2 2 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 CCF47648.1 - 3.2e-13 49.9 1.3 9e-13 48.4 0.1 2.4 2 0 0 2 2 2 1 Elongation factor Tu domain 2 EFG_II PF14492.6 CCF47648.1 - 3.3e-12 46.3 0.0 1.1e-11 44.6 0.0 1.9 2 0 0 2 2 2 1 Elongation Factor G, domain II DUF1962 PF09227.10 CCF47650.1 - 0.013 15.9 0.4 0.021 15.2 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1962) Cas_CT1975 PF09344.10 CCF47650.1 - 0.29 10.6 2.1 0.29 10.5 2.1 1.1 1 0 0 1 1 1 0 CT1975-like protein Ribosomal_L23 PF00276.20 CCF47651.1 - 2.9e-11 43.6 0.0 5.7e-11 42.6 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L23 TFIIE_alpha PF02002.17 CCF47651.1 - 0.12 12.2 0.2 0.43 10.5 0.0 1.8 2 0 0 2 2 2 0 TFIIE alpha subunit MT-A70 PF05063.14 CCF47652.1 - 5.3e-33 114.4 0.0 7.1e-33 113.9 0.0 1.2 1 0 0 1 1 1 1 MT-A70 zf-C2H2_assoc PF16606.5 CCF47652.1 - 0.059 13.6 0.3 0.16 12.2 0.3 1.7 1 0 0 1 1 1 0 Unstructured conserved, between two C2H2-type zinc-fingers Mito_carr PF00153.27 CCF47653.1 - 3.7e-60 199.9 3.0 1.1e-21 76.6 0.1 3.7 3 1 0 3 3 3 3 Mitochondrial carrier protein PBP_N PF17093.5 CCF47653.1 - 0.034 14.4 0.2 0.094 13.0 0.2 1.7 1 0 0 1 1 1 0 Penicillin-binding protein N-terminus Serine_protease PF18405.1 CCF47653.1 - 0.097 11.8 0.0 3.8 6.6 0.0 2.4 2 0 0 2 2 2 0 Gammaproteobacterial serine protease Methyltransf_3 PF01596.17 CCF47654.1 - 1.4e-12 47.2 0.0 2e-12 46.8 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 CCF47654.1 - 1.3e-09 39.0 0.0 2.2e-09 38.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain DHQ_synthase PF01761.20 CCF47655.1 - 5.8e-29 101.0 0.1 8.1e-29 100.6 0.1 1.2 1 0 0 1 1 1 1 3-dehydroquinate synthase Fe-ADH_2 PF13685.6 CCF47655.1 - 2.6e-08 33.9 0.0 3.2e-08 33.6 0.0 1.1 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH PF00465.19 CCF47655.1 - 0.0064 15.4 0.0 0.0086 14.9 0.0 1.1 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Cofilin_ADF PF00241.20 CCF47656.1 - 4.2e-39 133.1 0.0 6.8e-22 77.5 0.0 2.1 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein AlaDh_PNT_N PF05222.15 CCF47657.1 - 1.3e-28 99.9 0.0 1.9e-28 99.5 0.0 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain Pex24p PF06398.11 CCF47658.1 - 0.13 11.2 2.0 0.12 11.3 0.8 1.5 1 1 0 1 1 1 0 Integral peroxisomal membrane peroxin 7tm_1 PF00001.21 CCF47658.1 - 0.96 8.7 12.5 0.011 15.1 4.0 1.9 2 1 0 2 2 2 0 7 transmembrane receptor (rhodopsin family) DUF2613 PF11021.8 CCF47660.1 - 0.057 13.5 0.8 0.19 11.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2613) PTR2 PF00854.21 CCF47660.1 - 0.11 11.3 3.5 2.6 6.8 1.5 2.3 1 1 1 2 2 2 0 POT family adh_short PF00106.25 CCF47662.1 - 9.1e-21 74.2 0.4 1.2e-20 73.8 0.4 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF47662.1 - 1.2e-13 51.2 1.4 1.6e-13 50.8 1.4 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF47662.1 - 4.9e-05 23.3 0.7 9.9e-05 22.3 0.7 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF47662.1 - 0.0027 17.2 0.2 0.014 14.9 0.2 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF2306 PF10067.9 CCF47663.1 - 1.6e-18 67.3 8.4 3.4e-18 66.3 8.4 1.5 1 0 0 1 1 1 1 Predicted membrane protein (DUF2306) DUF997 PF06196.12 CCF47663.1 - 8.8 6.4 7.5 0.37 10.8 0.5 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF997) HMGL-like PF00682.19 CCF47664.1 - 6.8e-67 225.8 0.4 9.9e-67 225.3 0.4 1.2 1 0 0 1 1 1 1 HMGL-like Oxidored_FMN PF00724.20 CCF47664.1 - 0.11 11.7 0.2 0.23 10.7 0.0 1.6 2 0 0 2 2 2 0 NADH:flavin oxidoreductase / NADH oxidase family Epimerase PF01370.21 CCF47665.1 - 5.8e-10 39.0 0.1 2.3e-09 37.1 0.1 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CCF47665.1 - 3e-06 26.9 0.0 7.5e-06 25.6 0.0 1.8 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 CCF47665.1 - 4.5e-06 26.7 0.0 1e-05 25.5 0.0 1.6 1 1 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 CCF47665.1 - 4.5e-05 22.7 0.0 0.0012 18.1 0.0 2.1 2 0 0 2 2 2 1 Male sterility protein 3Beta_HSD PF01073.19 CCF47665.1 - 5.9e-05 22.2 0.0 8.1e-05 21.8 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NmrA PF05368.13 CCF47665.1 - 0.0024 17.5 0.2 0.0039 16.8 0.2 1.4 1 1 0 1 1 1 1 NmrA-like family adh_short PF00106.25 CCF47665.1 - 0.0085 15.6 0.0 0.033 13.6 0.0 1.9 2 0 0 2 2 2 1 short chain dehydrogenase Pro-kuma_activ PF09286.11 CCF47669.1 - 9.9e-28 97.2 0.0 2.2e-27 96.1 0.0 1.6 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 CCF47669.1 - 0.0019 17.5 0.5 0.0045 16.3 0.5 1.5 1 1 0 1 1 1 1 Subtilase family FAD_binding_4 PF01565.23 CCF47670.1 - 1.4e-21 76.7 0.1 2e-21 76.2 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CCF47671.1 - 1.4e-28 100.0 0.0 1.8e-28 99.6 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCF47671.1 - 7.4e-10 39.3 0.1 1.6e-07 31.8 0.1 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCF47671.1 - 0.001 18.4 0.2 0.0057 16.0 0.2 2.4 2 1 1 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 CCF47671.1 - 0.0038 16.1 1.3 2 7.2 1.1 2.7 2 1 1 3 3 3 2 Tryptophan halogenase NAD_binding_9 PF13454.6 CCF47671.1 - 0.027 14.5 3.6 11 6.0 0.1 3.7 4 0 0 4 4 4 0 FAD-NAD(P)-binding DAO PF01266.24 CCF47671.1 - 0.071 12.7 7.3 11 5.5 0.0 3.9 3 1 1 4 4 4 0 FAD dependent oxidoreductase ORC3_N PF07034.11 CCF47671.1 - 0.081 12.0 0.0 0.13 11.4 0.0 1.2 1 0 0 1 1 1 0 Origin recognition complex (ORC) subunit 3 N-terminus Abhydrolase_1 PF00561.20 CCF47671.1 - 0.15 11.7 0.0 0.51 9.9 0.0 1.9 2 0 0 2 2 2 0 alpha/beta hydrolase fold HI0933_like PF03486.14 CCF47671.1 - 0.16 10.6 0.2 6.7 5.3 0.0 2.3 2 0 0 2 2 2 0 HI0933-like protein Pec_lyase_C PF00544.19 CCF47673.1 - 9.8e-18 64.5 11.9 1.8e-16 60.4 11.9 2.1 1 1 0 1 1 1 1 Pectate lyase Beta_helix PF13229.6 CCF47673.1 - 0.00011 22.1 13.9 0.00091 19.1 13.9 2.1 1 1 0 1 1 1 1 Right handed beta helix region AAA_29 PF13555.6 CCF47673.1 - 0.17 11.6 1.9 8.7 6.2 0.1 2.9 3 0 0 3 3 3 0 P-loop containing region of AAA domain CLTH PF10607.9 CCF47674.1 - 4.2e-13 49.4 0.0 4.5e-13 49.3 0.0 1.1 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain CAC1F_C PF16885.5 CCF47675.1 - 0.29 10.8 0.5 0.36 10.5 0.5 1.1 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term Ras PF00071.22 CCF47677.1 - 2.9e-06 27.0 0.0 4.9e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCF47677.1 - 0.0023 18.1 0.0 0.003 17.8 0.0 1.4 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_24 PF13479.6 CCF47677.1 - 0.011 15.5 0.0 0.014 15.1 0.0 1.1 1 0 0 1 1 1 0 AAA domain SRPRB PF09439.10 CCF47677.1 - 0.07 12.6 0.0 0.1 12.0 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit PduV-EutP PF10662.9 CCF47677.1 - 0.11 12.3 0.1 0.27 11.0 0.0 1.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Glyco_transf_28 PF03033.20 CCF47679.1 - 0.0019 18.2 0.0 0.0022 18.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain Glyco_trans_4_4 PF13579.6 CCF47679.1 - 0.01 16.3 2.2 0.012 16.0 2.2 1.1 1 0 0 1 1 1 0 Glycosyl transferase 4-like domain AMP-binding PF00501.28 CCF47681.1 - 2e-70 237.5 0.0 2.4e-70 237.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme ACAS_N PF16177.5 CCF47681.1 - 1.5e-19 69.6 0.2 1.5e-19 69.6 0.2 2.7 3 0 0 3 3 3 1 Acetyl-coenzyme A synthetase N-terminus AMP-binding_C PF13193.6 CCF47681.1 - 1.1e-17 64.7 0.1 3e-17 63.4 0.1 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Stn1_C PF12659.7 CCF47681.1 - 0.038 13.9 0.0 0.07 13.1 0.0 1.3 1 0 0 1 1 1 0 Telomere capping C-terminal wHTH BRCT_2 PF16589.5 CCF47682.1 - 4.3e-06 27.1 0.0 7.5e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain PTCB-BRCT PF12738.7 CCF47682.1 - 7.6e-05 22.6 0.4 0.00021 21.2 0.1 1.9 2 0 0 2 2 2 1 twin BRCT domain LIG3_BRCT PF16759.5 CCF47682.1 - 0.0046 17.2 0.0 0.024 14.9 0.0 2.0 2 0 0 2 2 2 1 DNA ligase 3 BRCT domain Peptidase_S8 PF00082.22 CCF47683.1 - 0.087 12.1 0.0 0.1 11.8 0.0 1.1 1 0 0 1 1 1 0 Subtilase family HsbA PF12296.8 CCF47684.1 - 1.1e-28 100.1 13.5 1.1e-28 100.1 13.5 1.7 2 0 0 2 2 2 1 Hydrophobic surface binding protein A HHH_8 PF14716.6 CCF47684.1 - 0.022 15.1 0.9 2 8.8 0.1 2.4 2 0 0 2 2 2 0 Helix-hairpin-helix domain Ribosomal_L5 PF00281.19 CCF47684.1 - 0.35 11.2 3.1 0.36 11.2 0.7 2.4 2 2 0 2 2 2 0 Ribosomal protein L5 NPV_P10 PF05531.12 CCF47684.1 - 2.9 8.4 5.7 47 4.6 5.7 2.6 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein peroxidase PF00141.23 CCF47686.1 - 7.2e-26 91.3 0.0 9.7e-26 90.9 0.0 1.2 1 0 0 1 1 1 1 Peroxidase ATP-synt PF00231.19 CCF47687.1 - 4.5e-34 118.4 0.8 6e-34 118.0 0.8 1.0 1 0 0 1 1 1 1 ATP synthase DUF4054 PF13262.6 CCF47687.1 - 0.099 12.7 0.4 6.5 6.8 0.1 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF4054) Amino_oxidase PF01593.24 CCF47688.1 - 1.9e-82 278.0 0.1 4.2e-70 237.3 0.0 2.1 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase SWIRM PF04433.17 CCF47688.1 - 1.4e-10 41.4 0.1 9.1e-10 38.8 0.1 2.2 2 0 0 2 2 2 1 SWIRM domain HMG_box PF00505.19 CCF47688.1 - 2.3e-07 31.1 1.2 2.3e-07 31.1 1.2 1.9 2 0 0 2 2 2 1 HMG (high mobility group) box NAD_binding_8 PF13450.6 CCF47688.1 - 2.4e-07 30.9 0.0 5.6e-07 29.7 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HMG_box_2 PF09011.10 CCF47688.1 - 2.7e-07 31.1 1.8 5.1e-07 30.2 1.8 1.5 1 0 0 1 1 1 1 HMG-box domain Pyr_redox_2 PF07992.14 CCF47688.1 - 4.8e-05 22.7 0.0 0.00092 18.5 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCF47688.1 - 0.0017 18.0 0.1 0.0035 17.0 0.1 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 CCF47688.1 - 0.082 12.9 0.0 0.74 9.8 0.0 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding Sec1 PF00995.23 CCF47689.1 - 9.2e-129 431.3 0.0 1e-128 431.1 0.0 1.0 1 0 0 1 1 1 1 Sec1 family Transposase_22 PF02994.14 CCF47689.1 - 0.042 14.0 0.0 1.5 9.0 0.0 3.1 3 0 0 3 3 3 0 L1 transposable element RBD-like domain UQ_con PF00179.26 CCF47690.1 - 1.1e-28 99.6 0.0 1.3e-28 99.4 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 CCF47690.1 - 2.4e-06 27.3 0.0 2.8e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 CCF47690.1 - 0.0028 17.5 0.1 0.0037 17.1 0.1 1.2 1 0 0 1 1 1 1 UEV domain RWD PF05773.22 CCF47690.1 - 0.0039 17.5 0.0 0.0048 17.2 0.0 1.3 1 0 0 1 1 1 1 RWD domain Mito_carr PF00153.27 CCF47691.1 - 3.3e-32 110.3 0.3 2.9e-21 75.2 0.0 2.1 2 0 0 2 2 2 2 Mitochondrial carrier protein Xpo1 PF08389.12 CCF47692.1 - 6.8e-20 71.6 2.9 5.8e-19 68.6 0.1 2.8 2 1 0 2 2 2 1 Exportin 1-like protein HEAT PF02985.22 CCF47692.1 - 0.00073 19.6 0.0 2.6 8.5 0.0 2.9 2 0 0 2 2 2 2 HEAT repeat DUF2018 PF09442.10 CCF47692.1 - 0.086 13.8 0.5 0.52 11.3 0.1 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF2018) COesterase PF00135.28 CCF47693.1 - 1.9e-06 27.1 0.0 2e-06 27.0 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_1 PF00561.20 CCF47696.1 - 2.7e-14 53.4 0.1 3.1e-14 53.2 0.1 1.0 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CCF47696.1 - 8.1e-08 31.8 0.2 9.4e-08 31.6 0.2 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CCF47696.1 - 5e-06 27.3 0.0 6e-06 27.0 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family AXE1 PF05448.12 CCF47696.1 - 0.035 12.8 0.4 3.6 6.2 0.0 2.0 1 1 1 2 2 2 0 Acetyl xylan esterase (AXE1) DHHC PF01529.20 CCF47697.1 - 1.1e-37 129.1 9.2 2.1e-37 128.2 9.2 1.5 1 0 0 1 1 1 1 DHHC palmitoyltransferase DUF4064 PF13273.6 CCF47697.1 - 0.046 14.0 1.3 0.071 13.4 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) TFIIA PF03153.13 CCF47698.1 - 0.1 12.6 22.3 0.15 12.1 22.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SNF2_N PF00176.23 CCF47699.1 - 1.5e-47 162.0 0.0 5.6e-46 156.9 0.0 2.5 1 1 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.15 CCF47699.1 - 1.2e-06 28.6 0.3 3.9e-06 27.0 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit zf-C3HC4 PF00097.25 CCF47699.1 - 9.9e-06 25.3 10.7 9.9e-06 25.3 10.7 2.0 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CCF47699.1 - 7.5e-05 22.5 11.5 7.5e-05 22.5 11.5 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Helicase_C PF00271.31 CCF47699.1 - 0.00012 22.4 0.1 0.00039 20.7 0.1 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain zf-RING_2 PF13639.6 CCF47699.1 - 0.00021 21.5 12.4 0.00021 21.5 12.4 2.4 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 CCF47699.1 - 0.0011 18.8 11.2 0.0011 18.8 11.2 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) AAA_34 PF13872.6 CCF47699.1 - 0.0077 15.1 0.0 0.021 13.7 0.0 1.7 1 0 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 DEAD PF00270.29 CCF47699.1 - 0.018 14.8 0.0 0.041 13.6 0.0 1.5 1 0 0 1 1 1 0 DEAD/DEAH box helicase zf-rbx1 PF12678.7 CCF47699.1 - 0.16 12.3 10.6 0.44 10.9 10.6 1.8 1 0 0 1 1 1 0 RING-H2 zinc finger domain CCDC50_N PF15295.6 CCF47699.1 - 0.3 11.2 4.4 1 9.5 3.7 2.2 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 50 N-terminus PKD PF00801.20 CCF47700.1 - 0.018 14.9 0.1 0.024 14.5 0.1 1.2 1 0 0 1 1 1 0 PKD domain HTH_51 PF18558.1 CCF47701.1 - 6e-18 64.5 0.0 1.1e-17 63.7 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain PP-binding PF00550.25 CCF47701.1 - 1.5e-12 47.7 0.4 3e-12 46.7 0.4 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site Cnl2_NKP2 PF09447.10 CCF47701.1 - 0.017 15.3 0.4 0.055 13.6 0.4 1.9 1 1 0 1 1 1 0 Cnl2/NKP2 family protein DUF3484 PF11983.8 CCF47701.1 - 0.067 14.3 2.5 0.071 14.2 0.8 1.9 2 0 0 2 2 2 0 Membrane-attachment and polymerisation-promoting switch XPG_I PF00867.18 CCF47702.1 - 0.087 13.2 0.0 0.11 12.8 0.0 1.3 1 1 0 1 1 1 0 XPG I-region SelP_N PF04592.14 CCF47702.1 - 3.5 7.0 12.8 4 6.8 12.8 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Mg_trans_NIPA PF05653.14 CCF47703.1 - 4e-36 124.6 7.2 5.8e-36 124.1 7.2 1.2 1 0 0 1 1 1 1 Magnesium transporter NIPA DUF998 PF06197.13 CCF47703.1 - 0.008 15.8 0.0 0.008 15.8 0.0 2.8 1 1 0 2 2 2 1 Protein of unknown function (DUF998) DUF4797 PF16051.5 CCF47703.1 - 0.045 13.7 0.1 0.11 12.5 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4797) DUF1461 PF07314.11 CCF47703.1 - 0.7 9.8 6.6 0.5 10.2 1.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1461) TssN PF17555.2 CCF47703.1 - 0.85 8.9 8.0 1.9 7.8 7.6 1.6 1 1 1 2 2 2 0 Type VI secretion system, TssN RRM_1 PF00076.22 CCF47704.1 - 2.1e-58 194.1 0.0 5.9e-17 61.3 0.0 6.1 5 1 1 6 6 6 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_Rrp7 PF17799.1 CCF47704.1 - 2.9e-05 23.9 1.8 0.48 10.2 0.0 3.8 3 1 1 4 4 4 2 Rrp7 RRM-like N-terminal domain RRM_7 PF16367.5 CCF47704.1 - 0.017 15.2 0.0 2.8 8.1 0.0 3.5 3 0 0 3 3 3 0 RNA recognition motif RRM_occluded PF16842.5 CCF47704.1 - 0.026 14.4 0.0 44 4.0 0.0 3.4 3 0 0 3 3 3 0 Occluded RNA-recognition motif Cnd3 PF12719.7 CCF47705.1 - 4.3e-92 308.4 4.5 4.3e-92 308.4 4.5 2.2 3 0 0 3 3 3 1 Nuclear condensing complex subunits, C-term domain HEAT_2 PF13646.6 CCF47705.1 - 5.3e-09 36.4 10.0 4.3e-05 23.8 1.6 4.6 4 0 0 4 4 4 3 HEAT repeats HEAT PF02985.22 CCF47705.1 - 1.8e-07 30.8 11.2 0.078 13.3 0.0 8.2 9 0 0 9 9 9 2 HEAT repeat Cnd1 PF12717.7 CCF47705.1 - 0.014 15.5 8.8 0.54 10.3 0.2 4.9 4 1 1 5 5 5 0 non-SMC mitotic condensation complex subunit 1 MSP1_C PF07462.11 CCF47705.1 - 0.17 10.6 1.5 0.29 9.8 1.5 1.3 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus DNA_pol_phi PF04931.13 CCF47705.1 - 0.17 10.0 4.3 0.74 7.9 0.0 2.9 3 0 0 3 3 3 0 DNA polymerase phi IFRD PF05004.13 CCF47705.1 - 0.25 10.4 7.8 0.13 11.4 0.7 3.2 3 1 1 4 4 4 0 Interferon-related developmental regulator (IFRD) CPP1-like PF11833.8 CCF47706.1 - 1.2 8.8 5.8 0.38 10.4 1.3 2.4 1 1 0 2 2 2 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like zf-Mss51 PF13824.6 CCF47707.1 - 1.2e-29 102.2 6.3 1.8e-29 101.6 6.3 1.3 1 0 0 1 1 1 1 Zinc-finger of mitochondrial splicing suppressor 51 zf-MYND PF01753.18 CCF47707.1 - 0.0043 17.1 0.8 0.0079 16.3 0.8 1.4 1 0 0 1 1 1 1 MYND finger Cyt-b5 PF00173.28 CCF47708.1 - 9.9e-20 70.5 0.0 4.4e-15 55.6 0.0 2.7 3 0 0 3 3 3 2 Cytochrome b5-like Heme/Steroid binding domain Methyltransf_12 PF08242.12 CCF47710.1 - 1.3e-05 25.8 0.0 1.6e-05 25.6 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF47710.1 - 0.012 16.2 0.0 0.014 16.1 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase domain ChlI PF13541.6 CCF47710.1 - 0.027 14.3 0.0 0.027 14.3 0.0 1.1 1 0 0 1 1 1 0 Subunit ChlI of Mg-chelatase Methyltransf_31 PF13847.6 CCF47710.1 - 0.034 14.0 0.0 0.034 13.9 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 CCF47710.1 - 0.045 13.6 0.0 0.051 13.4 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 CCF47710.1 - 0.099 13.4 0.0 0.11 13.2 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase domain SelK_SelG PF10961.8 CCF47711.1 - 2.2 9.0 6.2 5.1 7.8 1.4 2.4 2 0 0 2 2 2 0 Selenoprotein SelK_SelG Flavokinase PF01687.17 CCF47712.1 - 5.3e-19 68.6 0.0 6.2e-19 68.3 0.0 1.1 1 0 0 1 1 1 1 Riboflavin kinase PAS PF00989.25 CCF47713.1 - 0.00023 21.2 0.0 0.00053 20.0 0.0 1.6 1 0 0 1 1 1 1 PAS fold Zn_clus PF00172.18 CCF47713.1 - 0.0028 17.7 8.8 0.0064 16.6 8.8 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 CCF47714.1 - 6.1e-35 120.8 30.4 7.5e-35 120.5 30.4 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF47714.1 - 1.3e-14 54.0 7.3 1.3e-14 54.0 7.3 1.7 1 1 0 1 1 1 1 Sugar (and other) transporter TRI12 PF06609.13 CCF47714.1 - 1e-09 37.4 3.9 1.4e-09 36.9 3.9 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_3 PF05977.13 CCF47714.1 - 0.019 13.4 3.6 0.03 12.7 3.6 1.3 1 0 0 1 1 1 0 Transmembrane secretion effector DUF3602 PF12223.8 CCF47715.1 - 1.3e-11 44.9 1.7 2.9e-06 27.8 0.0 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF3602) DUF1604 PF07713.13 CCF47717.1 - 0.024 14.4 1.4 0.04 13.7 0.5 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1604) Lipase_GDSL PF00657.22 CCF47719.1 - 5.6e-08 33.0 0.0 7.4e-08 32.6 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 CCF47719.1 - 2e-07 31.6 2.4 3e-07 31.0 2.4 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family BPL_N PF09825.9 CCF47720.1 - 2.2e-131 438.4 0.0 2.6e-131 438.2 0.0 1.0 1 0 0 1 1 1 1 Biotin-protein ligase, N terminal ADH_N PF08240.12 CCF47721.1 - 8.5e-29 99.6 0.3 1.8e-28 98.6 0.3 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCF47721.1 - 2.6e-10 40.4 0.4 5.9e-10 39.2 0.4 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_assoc PF13823.6 CCF47721.1 - 1.4e-06 28.1 0.4 3.3e-06 26.9 0.4 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-associated Glu_dehyd_C PF16912.5 CCF47721.1 - 5.8e-05 22.7 0.1 0.00012 21.6 0.0 1.5 2 0 0 2 2 2 1 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 CCF47721.1 - 0.00038 19.8 0.4 0.00092 18.6 0.3 1.6 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 CCF47721.1 - 0.003 16.3 0.1 0.004 15.9 0.1 1.2 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_3 PF01494.19 CCF47721.1 - 0.019 14.2 0.1 0.029 13.6 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain Pyr_redox PF00070.27 CCF47721.1 - 0.042 14.4 0.4 0.67 10.6 0.2 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 CCF47721.1 - 0.13 12.5 0.1 0.2 11.9 0.1 1.3 1 0 0 1 1 1 0 TrkA-N domain GIDA PF01134.22 CCF47721.1 - 0.18 10.9 0.4 0.24 10.4 0.4 1.1 1 0 0 1 1 1 0 Glucose inhibited division protein A 3HCDH_N PF02737.18 CCF47721.1 - 0.2 11.5 0.2 0.26 11.2 0.2 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FYVE_2 PF02318.16 CCF47723.1 - 0.003 17.8 21.0 0.51 10.6 1.6 3.4 3 0 0 3 3 3 3 FYVE-type zinc finger IBR PF01485.21 CCF47723.1 - 0.5 10.6 32.2 0.7 10.2 5.6 3.6 3 0 0 3 3 3 0 IBR domain, a half RING-finger domain Auxin_repressed PF05564.12 CCF47723.1 - 2.3 8.9 7.8 14 6.4 5.9 2.6 1 1 1 2 2 2 0 Dormancy/auxin associated protein 2TM PF13239.6 CCF47724.1 - 0.084 13.2 0.1 0.21 11.9 0.1 1.7 1 0 0 1 1 1 0 2TM domain Abhydrolase_3 PF07859.13 CCF47725.1 - 1.1e-07 31.9 0.0 1.9e-07 31.1 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 CCF47725.1 - 0.00041 19.4 0.0 0.00052 19.0 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family MFS_1 PF07690.16 CCF47727.1 - 5.7e-16 58.4 10.6 5.7e-16 58.4 10.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Hist_deacetyl PF00850.19 CCF47729.1 - 1e-77 261.7 0.0 1.4e-77 261.2 0.0 1.2 1 0 0 1 1 1 1 Histone deacetylase domain DUF4648 PF15505.6 CCF47729.1 - 0.052 14.4 0.0 0.37 11.7 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4648) ING PF12998.7 CCF47730.1 - 1.9e-22 79.7 2.7 2.8e-22 79.2 2.7 1.2 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 CCF47730.1 - 5.6e-05 22.9 8.8 0.00012 21.9 8.8 1.5 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.6 CCF47730.1 - 0.057 13.7 0.6 0.12 12.6 0.6 1.6 1 0 0 1 1 1 0 PHD-like zinc-binding domain DUF2552 PF10827.8 CCF47730.1 - 0.18 12.0 0.0 0.6 10.3 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2552) zf-RING_2 PF13639.6 CCF47730.1 - 0.55 10.6 6.7 1.2 9.6 6.7 1.6 1 0 0 1 1 1 0 Ring finger domain Septin PF00735.18 CCF47732.1 - 9.8e-43 146.4 0.7 1.1e-42 146.2 0.7 1.0 1 0 0 1 1 1 1 Septin GH131_N PF18271.1 CCF47733.1 - 1e-20 74.5 0.0 1.1e-20 74.4 0.0 1.0 1 0 0 1 1 1 1 Glycoside hydrolase 131 catalytic N-terminal domain PBP1_TM PF14812.6 CCF47734.1 - 1.5 9.3 6.3 4.4 7.7 2.0 2.3 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal IBR PF01485.21 CCF47735.1 - 1.3e-07 31.7 10.4 3e-07 30.6 10.4 1.6 1 0 0 1 1 1 1 IBR domain, a half RING-finger domain DUF4407 PF14362.6 CCF47735.1 - 1.7 7.9 9.4 2.5 7.4 9.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) zf-RING_7 PF02591.15 CCF47736.1 - 0.054 13.7 0.0 0.14 12.4 0.0 1.9 1 1 0 1 1 1 0 C4-type zinc ribbon domain FG-GAP_2 PF14312.6 CCF47737.1 - 0.043 14.1 0.2 0.077 13.3 0.2 1.5 1 0 0 1 1 1 0 FG-GAP repeat FAD_binding_2 PF00890.24 CCF47738.1 - 4.1e-123 411.6 4.7 5.1e-123 411.2 4.7 1.1 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 CCF47738.1 - 4.2e-43 146.4 0.2 6.5e-43 145.8 0.2 1.3 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term Pyr_redox_2 PF07992.14 CCF47738.1 - 3.8e-06 26.4 1.0 0.0017 17.7 0.5 2.9 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CCF47738.1 - 4.1e-05 22.8 1.4 0.017 14.3 2.1 2.2 2 0 0 2 2 2 2 Glucose inhibited division protein A Thi4 PF01946.17 CCF47738.1 - 6.6e-05 22.3 0.2 0.031 13.5 0.1 2.4 2 0 0 2 2 2 2 Thi4 family FAD_binding_3 PF01494.19 CCF47738.1 - 0.0057 15.9 0.1 0.0057 15.9 0.1 2.3 3 0 0 3 3 3 1 FAD binding domain DAO PF01266.24 CCF47738.1 - 0.083 12.5 1.3 0.16 11.5 1.3 1.6 1 1 0 1 1 1 0 FAD dependent oxidoreductase HI0933_like PF03486.14 CCF47738.1 - 0.1 11.3 0.8 0.3 9.7 0.4 2.0 2 0 0 2 2 2 0 HI0933-like protein Fer2_3 PF13085.6 CCF47739.1 - 7.9e-33 112.7 0.0 1.2e-32 112.1 0.0 1.3 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_17 PF13534.6 CCF47739.1 - 1.3e-08 35.2 5.7 1.3e-08 35.2 5.7 2.2 3 0 0 3 3 3 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 CCF47739.1 - 9.5e-08 32.4 6.3 9.5e-08 32.4 6.3 2.2 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 CCF47739.1 - 1.2e-07 31.8 2.9 1.2e-07 31.8 2.9 2.0 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer2 PF00111.27 CCF47739.1 - 0.0024 17.8 3.0 0.0032 17.4 0.3 2.3 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer4_7 PF12838.7 CCF47739.1 - 0.0027 18.3 4.6 0.0027 18.3 4.6 2.4 2 2 0 2 2 2 1 4Fe-4S dicluster domain Fer4_9 PF13187.6 CCF47739.1 - 0.35 11.1 12.6 1.1 9.5 9.6 2.8 2 1 2 4 4 4 0 4Fe-4S dicluster domain DUF3712 PF12505.8 CCF47740.1 - 1.9e-25 89.5 3.5 3.7e-25 88.6 3.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF3712) SBF_like PF13593.6 CCF47740.1 - 0.0078 15.6 0.1 0.011 15.1 0.1 1.1 1 0 0 1 1 1 1 SBF-like CPA transporter family (DUF4137) FAD_binding_2 PF00890.24 CCF47741.1 - 0.2 10.7 0.0 0.31 10.1 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain Ketoacyl-synt_C PF02801.22 CCF47742.1 - 2.1e-32 111.6 0.1 3.5e-32 110.9 0.1 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 CCF47742.1 - 1.6e-12 47.9 0.0 3.8e-12 46.7 0.0 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Acyl_transf_1 PF00698.21 CCF47742.1 - 1.4e-11 44.5 0.0 2.2e-11 43.8 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain Pex14_N PF04695.13 CCF47744.1 - 9.4e-40 136.8 4.0 9.4e-40 136.8 4.0 2.8 2 1 1 3 3 3 1 Peroxisomal membrane anchor protein (Pex14p) conserved region PAPA-1 PF04795.12 CCF47745.1 - 1.3e-24 86.8 0.6 1.3e-24 86.8 0.6 4.0 4 1 1 5 5 5 1 PAPA-1-like conserved region NOA36 PF06524.12 CCF47745.1 - 0.89 8.8 36.6 0.46 9.7 18.2 2.4 2 0 0 2 2 2 0 NOA36 protein Cu-oxidase PF00394.22 CCF47746.1 - 1.7e-14 54.3 0.0 2.3e-14 53.8 0.0 1.2 1 1 0 1 1 1 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 CCF47749.1 - 5.7e-07 29.3 0.0 8.4e-07 28.8 0.0 1.2 1 0 0 1 1 1 1 Multicopper oxidase AMMECR1 PF01871.17 CCF47750.1 - 9.7e-46 155.4 0.0 1.3e-45 155.0 0.0 1.2 1 0 0 1 1 1 1 AMMECR1 Defensin_big PF14862.6 CCF47751.1 - 0.17 12.2 0.3 0.21 11.9 0.3 1.3 1 0 0 1 1 1 0 Big defensin HMGL-like PF00682.19 CCF47752.1 - 1.3e-64 218.3 0.0 3.2e-64 217.1 0.0 1.6 2 0 0 2 2 2 1 HMGL-like LeuA_dimer PF08502.10 CCF47752.1 - 1.8e-22 79.6 0.0 4.1e-22 78.5 0.0 1.6 1 0 0 1 1 1 1 LeuA allosteric (dimerisation) domain LysM PF01476.20 CCF47753.1 - 6.4e-08 32.5 0.4 0.12 12.4 0.0 3.8 4 0 0 4 4 4 3 LysM domain zf-C3HC4_3 PF13920.6 CCF47754.1 - 4.3e-07 29.7 8.3 4.3e-07 29.7 8.3 3.6 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CCF47754.1 - 0.00021 21.1 12.3 0.00021 21.1 12.3 3.1 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CCF47754.1 - 0.015 15.2 13.1 0.015 15.2 13.1 3.3 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CCF47754.1 - 0.019 15.3 11.8 0.019 15.3 11.8 3.7 4 0 0 4 4 4 0 Ring finger domain Zn_ribbon_recom PF13408.6 CCF47754.1 - 4.9 7.7 10.1 0.93 10.1 1.3 2.9 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain E_raikovi_mat PF06360.11 CCF47754.1 - 6 7.4 8.1 1.4 9.4 0.5 3.1 3 0 0 3 3 3 0 Euplotes raikovi mating pheromone DZR PF12773.7 CCF47754.1 - 7.3 6.7 19.2 3.9 7.6 7.6 3.7 3 1 1 4 4 4 0 Double zinc ribbon Taxilin PF09728.9 CCF47756.1 - 1.5e-57 195.2 34.9 1.6e-57 195.0 34.9 1.0 1 0 0 1 1 1 1 Myosin-like coiled-coil protein DHR10 PF18595.1 CCF47756.1 - 0.83 9.7 25.7 0.066 13.3 1.5 3.6 2 1 1 3 3 3 0 Designed helical repeat protein 10 domain TMF_TATA_bd PF12325.8 CCF47756.1 - 1.1 9.5 26.3 0.74 10.1 12.9 3.0 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding GAS PF13851.6 CCF47756.1 - 1.2 8.5 30.6 0.22 10.9 18.8 2.1 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding FliD_N PF02465.18 CCF47756.1 - 4.3 8.1 11.4 4.3 8.1 1.6 2.4 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus DUF4661 PF15576.6 CCF47756.1 - 5.8 6.7 7.3 4.1 7.2 6.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4661) Seryl_tRNA_N PF02403.22 CCF47756.1 - 9.7 6.5 25.4 3.3 8.0 2.2 2.8 1 1 2 3 3 3 0 Seryl-tRNA synthetase N-terminal domain TSC22 PF01166.18 CCF47756.1 - 9.9 6.6 15.8 1.7 9.0 1.6 3.4 3 1 1 4 4 4 0 TSC-22/dip/bun family Aminotran_3 PF00202.21 CCF47758.1 - 9.2e-72 241.9 0.0 1e-71 241.7 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III SIL1 PF16782.5 CCF47762.1 - 5.1e-08 32.5 0.0 9e-08 31.7 0.0 1.4 1 1 0 1 1 1 1 Nucleotide exchange factor SIL1 Ribosomal_S19 PF00203.21 CCF47763.1 - 4.9e-33 112.9 0.2 6.7e-33 112.4 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein S19 EpmC PF04315.12 CCF47763.1 - 0.068 12.9 0.0 4.3 7.0 0.0 2.2 2 0 0 2 2 2 0 Elongation factor P hydroxylase Glyco_hydro_53 PF07745.13 CCF47764.1 - 4.9e-100 334.8 0.5 5.6e-100 334.6 0.5 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 53 NTF2 PF02136.20 CCF47766.1 - 4.1e-31 108.1 0.1 4.5e-31 107.9 0.1 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain DUF4518 PF15008.6 CCF47766.1 - 0.15 11.2 0.3 0.85 8.7 0.3 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4518) DUF4440 PF14534.6 CCF47766.1 - 0.18 12.2 0.0 0.22 11.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) Pro_CA PF00484.19 CCF47767.1 - 9.4e-47 159.2 0.4 1.4e-46 158.7 0.4 1.2 1 0 0 1 1 1 1 Carbonic anhydrase Ribosomal_L7Ae PF01248.26 CCF47768.1 - 7.5e-21 73.7 0.5 1.3e-20 72.9 0.5 1.4 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family ATP_bind_3 PF01171.20 CCF47769.1 - 9e-18 64.7 0.0 1.4e-17 64.0 0.0 1.3 1 0 0 1 1 1 1 PP-loop family zn-ribbon_14 PF16503.5 CCF47769.1 - 2.1e-16 59.1 3.9 2.1e-16 59.1 3.9 4.2 5 0 0 5 5 5 2 Zinc-ribbon RecR PF02132.15 CCF47769.1 - 0.018 14.6 0.2 0.018 14.6 0.2 3.1 3 0 0 3 3 3 0 RecR protein tRNA_Me_trans PF03054.16 CCF47769.1 - 0.019 13.8 0.0 0.034 12.9 0.0 1.4 1 0 0 1 1 1 0 tRNA methyl transferase GATA PF00320.27 CCF47769.1 - 0.058 13.0 0.6 0.058 13.0 0.6 3.4 3 1 1 4 4 4 0 GATA zinc finger zf-UBR PF02207.20 CCF47769.1 - 0.31 11.3 8.0 2.6 8.3 0.2 2.9 3 0 0 3 3 3 0 Putative zinc finger in N-recognin (UBR box) TF_Zn_Ribbon PF08271.12 CCF47769.1 - 8 6.1 8.9 1.3 8.6 0.1 3.1 3 0 0 3 3 3 0 TFIIB zinc-binding MWFE PF15879.5 CCF47770.1 - 3.3e-31 107.2 1.0 4.1e-31 106.9 1.0 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase MWFE subunit MOZ_SAS PF01853.18 CCF47771.1 - 6e-75 250.8 0.0 8.8e-75 250.3 0.0 1.2 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 CCF47771.1 - 7e-21 73.6 3.1 1.5e-20 72.5 3.1 1.6 1 0 0 1 1 1 1 MYST family zinc finger domain PHD_4 PF16866.5 CCF47771.1 - 4.5e-06 26.7 8.3 4.5e-06 26.7 8.3 2.0 2 0 0 2 2 2 1 PHD-finger PHD PF00628.29 CCF47771.1 - 0.0053 16.6 9.3 0.0053 16.6 9.3 2.2 2 0 0 2 2 2 1 PHD-finger PHD_2 PF13831.6 CCF47771.1 - 0.15 11.7 1.4 0.39 10.3 1.4 1.8 1 0 0 1 1 1 0 PHD-finger Acetyltransf_7 PF13508.7 CCF47771.1 - 0.18 12.2 0.0 0.37 11.3 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain zf-piccolo PF05715.13 CCF47771.1 - 2.5 8.3 6.2 5.1 7.3 6.2 1.5 1 0 0 1 1 1 0 Piccolo Zn-finger C1_1 PF00130.22 CCF47771.1 - 7.5 6.5 7.5 0.41 10.6 1.6 2.0 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DDE_1 PF03184.19 CCF47772.1 - 6.7e-14 51.9 0.0 1.8e-13 50.5 0.0 1.8 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 CCF47772.1 - 1.3e-10 41.2 0.1 3.3e-10 39.9 0.1 1.7 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 CCF47772.1 - 2.8e-08 33.4 0.1 4.9e-08 32.6 0.1 1.4 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_28 PF13518.6 CCF47772.1 - 0.003 17.6 0.8 0.0094 16.1 0.2 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.6 CCF47772.1 - 0.007 16.1 0.1 0.023 14.5 0.1 1.8 1 0 0 1 1 1 1 Homeodomain-like domain HTH_7 PF02796.15 CCF47772.1 - 0.008 16.2 0.6 0.016 15.3 0.6 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_Tnp_IS630 PF01710.16 CCF47772.1 - 0.03 14.4 0.0 0.056 13.5 0.0 1.4 1 0 0 1 1 1 0 Transposase HTH_Tnp_ISL3 PF13542.6 CCF47772.1 - 0.068 12.6 0.0 0.14 11.6 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 HTH_8 PF02954.19 CCF47772.1 - 0.078 12.8 0.2 0.22 11.4 0.2 1.8 1 1 0 1 1 1 0 Bacterial regulatory protein, Fis family Sugar_tr PF00083.24 CCF47774.1 - 1.9e-16 60.0 20.2 2e-16 59.9 20.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter Methyltransf_23 PF13489.6 CCF47775.1 - 0.046 13.6 0.0 0.052 13.4 0.0 1.0 1 0 0 1 1 1 0 Methyltransferase domain RabGAP-TBC PF00566.18 CCF47776.1 - 1.2e-07 31.6 0.0 1.3e-07 31.5 0.0 1.0 1 0 0 1 1 1 1 Rab-GTPase-TBC domain GTP1_OBG PF01018.22 CCF47778.1 - 3.5e-40 137.1 1.0 3e-29 101.6 2.9 2.2 2 0 0 2 2 2 2 GTP1/OBG MMR_HSR1 PF01926.23 CCF47778.1 - 2.5e-24 85.6 0.0 4.9e-24 84.6 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CCF47778.1 - 5.9e-09 35.6 0.1 5.8e-08 32.4 0.1 2.4 3 0 0 3 3 3 1 Ferrous iron transport protein B MeaB PF03308.16 CCF47778.1 - 0.00019 20.5 0.1 0.26 10.2 0.0 2.2 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB GTP_EFTU PF00009.27 CCF47778.1 - 0.0012 18.4 0.0 0.098 12.2 0.0 2.3 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Arf PF00025.21 CCF47778.1 - 0.0013 18.3 0.0 0.098 12.1 0.0 2.2 2 0 0 2 2 2 1 ADP-ribosylation factor family ABC_tran PF00005.27 CCF47778.1 - 0.031 14.8 0.0 0.058 13.9 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_18 PF13238.6 CCF47778.1 - 0.1 13.1 0.0 0.46 11.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 CCF47778.1 - 0.15 11.6 0.0 16 5.1 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Aldolase_II PF00596.21 CCF47779.1 - 1.6e-45 155.3 0.0 2.2e-45 154.9 0.0 1.2 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Methyltr_RsmB-F PF01189.17 CCF47780.1 - 1.9e-32 112.5 0.0 2.8e-25 89.1 0.0 3.2 3 0 0 3 3 3 2 16S rRNA methyltransferase RsmB/F AIF-MLS PF14962.6 CCF47780.1 - 1.2 9.0 31.6 3.7 7.5 6.4 2.3 2 0 0 2 2 2 0 Mitochondria Localisation Sequence Anoctamin PF04547.12 CCF47781.1 - 7.2e-43 147.1 0.0 8.9e-43 146.7 0.0 1.0 1 0 0 1 1 1 1 Calcium-activated chloride channel Glyco_hydro_18 PF00704.28 CCF47782.1 - 1.5e-68 231.9 0.2 1.6e-68 231.8 0.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 CobN-Mg_chel PF02514.16 CCF47784.1 - 0.11 10.2 0.0 0.15 9.8 0.0 1.1 1 0 0 1 1 1 0 CobN/Magnesium Chelatase PSD4 PF07631.11 CCF47784.1 - 0.13 12.8 0.1 0.19 12.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1592) DUF4199 PF13858.6 CCF47785.1 - 0.075 13.4 0.0 0.076 13.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) Tim17 PF02466.19 CCF47788.1 - 2.4e-32 111.6 8.1 3.1e-32 111.2 8.1 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Nup84_Nup100 PF04121.13 CCF47789.1 - 3.5e-133 445.3 0.0 4.3e-133 445.0 0.0 1.0 1 0 0 1 1 1 1 Nuclear pore protein 84 / 107 Mod_r PF07200.13 CCF47790.1 - 4.3e-32 111.2 1.6 5e-32 111.0 1.6 1.0 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein Cofilin_ADF PF00241.20 CCF47791.1 - 0.034 13.9 0.0 0.085 12.7 0.0 1.6 2 0 0 2 2 2 0 Cofilin/tropomyosin-type actin-binding protein Glyco_hydro_3_C PF01915.22 CCF47792.1 - 1.3e-30 106.9 0.0 1.7e-30 106.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain PA14 PF07691.12 CCF47792.1 - 1.2e-07 31.6 0.0 1.9e-07 31.0 0.0 1.2 1 0 0 1 1 1 1 PA14 domain Glyco_hydro_3 PF00933.21 CCF47792.1 - 0.0018 17.7 0.0 0.0041 16.5 0.0 1.6 2 0 0 2 2 2 1 Glycosyl hydrolase family 3 N terminal domain DUF3237 PF11578.8 CCF47792.1 - 0.081 12.8 0.0 0.18 11.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3237) GLEYA PF10528.9 CCF47792.1 - 0.088 13.2 0.0 0.19 12.2 0.0 1.5 1 0 0 1 1 1 0 GLEYA domain hnRNP_Q_AcD PF18360.1 CCF47792.1 - 0.097 12.6 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 Heterogeneous nuclear ribonucleoprotein Q acidic domain stn_TNFRSF12A PF12191.8 CCF47794.1 - 0.0083 16.3 0.0 0.0091 16.2 0.0 1.1 1 0 0 1 1 1 1 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain IPTL-CTERM PF18203.1 CCF47794.1 - 0.0087 16.0 3.7 0.0087 16.0 3.7 1.9 2 0 0 2 2 2 1 IPTL-CTERM motif DUF4381 PF14316.6 CCF47794.1 - 0.011 16.0 0.0 0.011 16.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) SKG6 PF08693.10 CCF47794.1 - 0.013 14.9 0.2 0.017 14.5 0.2 1.2 1 0 0 1 1 1 0 Transmembrane alpha-helix domain EphA2_TM PF14575.6 CCF47794.1 - 0.018 15.9 0.0 0.02 15.8 0.0 1.1 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain PTP_tm PF18861.1 CCF47794.1 - 0.21 11.6 0.2 0.26 11.3 0.2 1.1 1 0 0 1 1 1 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J Gram_pos_anchor PF00746.21 CCF47794.1 - 2.5 8.1 4.1 6.4 6.8 4.1 1.8 1 1 0 1 1 1 0 LPXTG cell wall anchor motif Putative_PNPOx PF01243.20 CCF47795.1 - 2.2e-05 24.6 0.0 0.00018 21.7 0.0 2.1 2 0 0 2 2 2 1 Pyridoxamine 5'-phosphate oxidase CholecysA-Rec_N PF09193.10 CCF47795.1 - 0.15 12.0 0.0 0.37 10.8 0.0 1.7 1 0 0 1 1 1 0 Cholecystokinin A receptor, N-terminal zf-C2H2_4 PF13894.6 CCF47797.1 - 0.02 15.7 12.9 2.2 9.4 0.4 3.6 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2 PF00096.26 CCF47797.1 - 0.041 14.3 10.9 1.4 9.5 0.1 3.7 3 0 0 3 3 3 0 Zinc finger, C2H2 type PAF-AH_p_II PF03403.13 CCF47798.1 - 1.9e-14 53.0 0.0 1.8e-06 26.8 0.0 2.8 2 1 0 2 2 2 2 Platelet-activating factor acetylhydrolase, isoform II Chlorophyllase2 PF12740.7 CCF47798.1 - 1.1e-07 31.0 0.0 2.8e-07 29.7 0.0 1.6 1 1 1 2 2 2 1 Chlorophyllase enzyme Hydrolase_4 PF12146.8 CCF47798.1 - 2e-05 24.0 0.0 0.024 13.9 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CCF47798.1 - 0.00013 22.6 2.6 0.00013 22.6 2.6 1.8 2 0 0 2 2 2 1 Alpha/beta hydrolase family Chlorophyllase PF07224.11 CCF47798.1 - 0.0076 15.3 0.0 0.023 13.7 0.0 1.6 1 1 0 1 1 1 1 Chlorophyllase Abhydrolase_2 PF02230.16 CCF47798.1 - 0.0096 15.7 0.0 0.013 15.3 0.0 1.2 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_1 PF00561.20 CCF47798.1 - 0.057 13.1 0.1 1.1 8.9 0.0 2.1 2 0 0 2 2 2 0 alpha/beta hydrolase fold Abhydrolase_5 PF12695.7 CCF47798.1 - 0.059 13.1 0.0 7.4 6.3 0.0 2.4 2 1 0 2 2 2 0 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 CCF47798.1 - 0.089 12.3 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family Zn_clus PF00172.18 CCF47799.1 - 0.075 13.2 1.9 0.14 12.3 1.9 1.4 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 CCF47800.1 - 3.8e-06 26.1 8.2 5e-06 25.7 8.2 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_1_like PF12832.7 CCF47800.1 - 8.6e-06 24.8 0.0 1e-05 24.6 0.0 1.1 1 0 0 1 1 1 1 MFS_1 like family Xan_ur_permease PF00860.20 CCF47801.1 - 6.2e-12 44.9 5.0 6.2e-12 44.9 5.0 2.5 3 0 0 3 3 3 2 Permease family MFS_MOT1 PF16983.5 CCF47801.1 - 0.21 12.0 8.6 0.053 13.9 3.9 2.3 1 1 0 2 2 2 0 Molybdate transporter of MFS superfamily DUF4956 PF16316.5 CCF47801.1 - 1.9 8.2 9.9 0.29 10.8 0.7 3.4 3 1 1 4 4 4 0 Domain of unknown function (DUF4956) Peptidase_S8 PF00082.22 CCF47806.1 - 7e-42 143.7 4.2 1.7e-41 142.5 3.5 1.9 2 0 0 2 2 2 1 Subtilase family fn3_5 PF06280.12 CCF47806.1 - 9.6e-08 32.7 0.0 2.2e-07 31.6 0.0 1.7 1 0 0 1 1 1 1 Fn3-like domain PG_isomerase_N PF18353.1 CCF47806.1 - 0.63 10.5 5.8 0.5 10.8 0.5 2.5 2 0 0 2 2 2 0 Phosphoglucose isomerase N-terminal domain Sugar_tr PF00083.24 CCF47807.1 - 5.3e-74 249.7 24.4 6.2e-74 249.5 24.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF47807.1 - 2.3e-20 72.9 22.5 2.3e-20 72.9 22.5 1.6 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 CCF47807.1 - 1.7e-06 27.2 1.1 1.7e-06 27.2 1.1 2.0 2 0 0 2 2 2 1 MFS_1 like family Phage_holin_2_4 PF16082.5 CCF47807.1 - 0.0041 16.8 0.8 0.073 12.8 0.1 2.6 2 0 0 2 2 2 1 Bacteriophage holin family, superfamily II-like DUF2207 PF09972.9 CCF47807.1 - 0.056 12.2 5.7 0.67 8.6 0.5 2.3 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) DUF3687 PF12459.8 CCF47807.1 - 0.071 12.6 0.0 0.25 10.9 0.0 1.9 1 0 0 1 1 1 0 D-Ala-teichoic acid biosynthesis protein DUF2852 PF11014.8 CCF47807.1 - 0.2 11.8 0.0 0.2 11.8 0.0 2.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2852) LysM PF01476.20 CCF47809.1 - 5.9e-14 51.9 0.1 9.9e-06 25.5 0.0 2.4 2 0 0 2 2 2 2 LysM domain RP-C_C PF11800.8 CCF47810.1 - 0.12 12.5 1.4 0.14 12.3 1.4 1.0 1 0 0 1 1 1 0 Replication protein C C-terminal region Dicty_REP PF05086.12 CCF47810.1 - 0.98 7.3 4.2 0.9 7.4 4.2 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein WSC PF01822.19 CCF47811.1 - 0.043 14.0 0.1 0.079 13.2 0.1 1.4 1 0 0 1 1 1 0 WSC domain DUF1996 PF09362.10 CCF47812.1 - 2.5e-45 155.3 0.2 3.2e-45 155.0 0.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) Pkinase PF00069.25 CCF47814.1 - 2.1e-20 73.2 0.0 4.3e-20 72.2 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF47814.1 - 6.6e-07 28.9 0.0 2.1e-06 27.2 0.0 1.7 2 1 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 CCF47814.1 - 0.011 15.6 0.2 0.069 13.1 0.0 2.0 2 0 0 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 CCF47814.1 - 0.06 12.7 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 CCF47814.1 - 0.064 12.0 0.0 0.12 11.1 0.0 1.4 2 0 0 2 2 2 0 Fungal protein kinase DDE_Tnp_ISAZ013 PF07592.11 CCF47814.1 - 0.12 11.3 0.0 0.2 10.6 0.0 1.3 1 0 0 1 1 1 0 Rhodopirellula transposase DDE domain DDE_1 PF03184.19 CCF47815.1 - 3.7e-07 30.0 0.0 5.3e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease zf-CCHC PF00098.23 CCF47815.1 - 2 8.7 5.0 3.5 7.9 5.0 1.4 1 0 0 1 1 1 0 Zinc knuckle p450 PF00067.22 CCF47816.1 - 2.9e-16 59.3 0.0 3.9e-16 58.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 HET PF06985.11 CCF47819.1 - 1.9e-12 47.7 6.4 2.9e-09 37.4 1.2 2.3 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) MMR_HSR1 PF01926.23 CCF47822.1 - 3.4e-17 62.6 0.2 3e-15 56.3 0.0 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CCF47822.1 - 1.2e-07 31.4 0.7 1.1e-05 25.1 0.1 2.2 2 0 0 2 2 2 2 Ferrous iron transport protein B RsgA_GTPase PF03193.16 CCF47822.1 - 2.5e-06 27.5 0.2 0.0018 18.2 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase Dynamin_N PF00350.23 CCF47822.1 - 0.0097 16.0 1.4 0.11 12.5 0.4 2.8 2 1 0 2 2 2 1 Dynamin family AIG1 PF04548.16 CCF47822.1 - 0.012 15.0 0.1 0.021 14.1 0.1 1.4 1 0 0 1 1 1 0 AIG1 family Tic22 PF04278.12 CCF47822.1 - 0.2 11.0 0.0 0.32 10.3 0.0 1.2 1 0 0 1 1 1 0 Tic22-like family DUF3046 PF11248.8 CCF47822.1 - 0.43 11.0 1.9 33 4.9 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3046) Rep_fac_C PF08542.11 CCF47823.1 - 2.5e-23 82.3 0.0 7.5e-23 80.8 0.0 1.9 2 0 0 2 2 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.6 CCF47823.1 - 3.8e-12 46.3 0.0 1e-08 35.1 0.0 2.3 1 1 1 2 2 2 2 DNA polymerase III, delta subunit AAA PF00004.29 CCF47823.1 - 1.8e-11 44.6 0.0 3.4e-11 43.7 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 CCF47823.1 - 4.9e-07 29.9 0.0 1.2e-06 28.6 0.0 1.6 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 CCF47823.1 - 2.8e-06 27.8 0.0 0.00021 21.7 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 CCF47823.1 - 8.3e-05 22.9 0.1 0.15 12.4 0.0 2.5 1 1 1 2 2 2 2 AAA domain RuvB_N PF05496.12 CCF47823.1 - 9.9e-05 22.1 0.0 0.00023 20.9 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Viral_helicase1 PF01443.18 CCF47823.1 - 0.00013 21.8 0.0 0.00021 21.1 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_3 PF07726.11 CCF47823.1 - 0.00032 20.6 0.0 0.0006 19.7 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta PF06144.13 CCF47823.1 - 0.0014 18.4 0.0 0.0023 17.7 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase III, delta subunit Rad17 PF03215.15 CCF47823.1 - 0.0027 17.6 0.0 0.0056 16.6 0.0 1.5 1 1 0 1 1 1 1 Rad17 P-loop domain Mg_chelatase PF01078.21 CCF47823.1 - 0.0041 16.5 0.0 0.038 13.4 0.0 2.1 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI MeaB PF03308.16 CCF47823.1 - 0.005 15.9 0.0 0.0091 15.0 0.0 1.4 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_assoc_2 PF16193.5 CCF47823.1 - 0.0054 17.1 0.0 0.018 15.4 0.0 2.0 1 0 0 1 1 1 1 AAA C-terminal domain AAA_11 PF13086.6 CCF47823.1 - 0.0071 16.2 0.0 0.011 15.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain TniB PF05621.11 CCF47823.1 - 0.011 15.2 0.0 3.9 6.9 0.0 2.4 2 0 0 2 2 2 0 Bacterial TniB protein NTPase_1 PF03266.15 CCF47823.1 - 0.015 15.2 0.2 0.067 13.1 0.1 2.1 1 1 1 2 2 2 0 NTPase AAA_19 PF13245.6 CCF47823.1 - 0.016 15.5 0.1 0.051 13.9 0.1 2.0 1 1 0 1 1 1 0 AAA domain DEAD PF00270.29 CCF47823.1 - 0.018 14.8 0.1 0.55 10.0 0.0 2.4 1 1 1 2 2 2 0 DEAD/DEAH box helicase KTI12 PF08433.10 CCF47823.1 - 0.02 14.3 0.0 0.04 13.4 0.0 1.5 1 1 0 1 1 1 0 Chromatin associated protein KTI12 DNA_pol3_gamma3 PF12169.8 CCF47823.1 - 0.024 14.6 0.2 0.55 10.1 0.0 2.8 3 0 0 3 3 3 0 DNA polymerase III subunits gamma and tau domain III AAA_24 PF13479.6 CCF47823.1 - 0.026 14.3 0.0 0.076 12.7 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 CCF47823.1 - 0.037 14.0 0.1 0.34 10.9 0.0 2.4 3 1 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 CCF47823.1 - 0.076 12.7 0.1 0.21 11.3 0.1 1.7 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.6 CCF47823.1 - 0.09 12.3 0.0 0.6 9.6 0.1 2.2 2 1 1 3 3 3 0 AAA domain Bacteriocin_IIc PF10439.9 CCF47824.1 - 0.088 12.9 3.4 0.13 12.4 3.4 1.2 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide UreF PF01730.16 CCF47825.1 - 5.3e-21 75.6 1.2 5.3e-21 75.6 1.2 1.7 2 0 0 2 2 2 1 UreF DUF429 PF04250.13 CCF47825.1 - 0.068 13.0 0.1 0.12 12.1 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF429) Med9 PF07544.13 CCF47825.1 - 0.07 13.2 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 Torus PF16131.5 CCF47826.1 - 1.1e-45 154.8 1.2 1.3e-45 154.5 0.1 1.7 2 0 0 2 2 2 1 Torus domain RRM_1 PF00076.22 CCF47826.1 - 3.9e-08 33.0 0.0 6.7e-08 32.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf_CCCH_4 PF18345.1 CCF47826.1 - 0.00013 21.9 0.6 0.00013 21.9 0.6 2.0 2 0 0 2 2 2 1 Zinc finger domain Nup35_RRM_2 PF14605.6 CCF47826.1 - 0.00087 19.2 0.0 0.0018 18.2 0.0 1.5 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif zf-CCCH PF00642.24 CCF47826.1 - 0.01 15.7 0.7 0.021 14.7 0.7 1.5 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) NBD_C PF17042.5 CCF47826.1 - 0.057 13.9 1.6 0.58 10.7 0.1 2.3 2 0 0 2 2 2 0 Nucleotide-binding C-terminal domain MMR_HSR1_Xtn PF16897.5 CCF47827.1 - 1.1e-34 118.7 2.2 1.7e-34 118.0 0.9 1.9 2 0 0 2 2 2 1 C-terminal region of MMR_HSR1 domain MMR_HSR1 PF01926.23 CCF47827.1 - 1.5e-20 73.4 0.0 4.1e-20 72.0 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase TGS PF02824.21 CCF47827.1 - 1.7e-19 69.6 0.0 2.9e-19 68.8 0.0 1.4 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.18 CCF47827.1 - 1.4e-12 47.4 0.0 2.3e-12 46.7 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 CCF47827.1 - 3.7e-05 23.9 0.3 0.039 14.0 0.0 2.6 1 1 1 2 2 2 2 Dynamin family MeaB PF03308.16 CCF47827.1 - 0.066 12.2 0.1 0.2 10.6 0.1 1.8 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB MCM PF00493.23 CCF47827.1 - 0.11 11.6 0.1 0.28 10.3 0.0 1.6 2 0 0 2 2 2 0 MCM P-loop domain ADH_N_2 PF16884.5 CCF47827.1 - 0.17 11.8 0.0 0.3 11.0 0.0 1.4 1 0 0 1 1 1 0 N-terminal domain of oxidoreductase adh_short PF00106.25 CCF47828.1 - 8.3e-20 71.1 2.8 8.9e-20 71.0 2.8 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF47828.1 - 4.6e-15 55.8 2.5 5.5e-15 55.6 2.5 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Polysacc_synt_2 PF02719.15 CCF47828.1 - 3.8e-05 23.0 0.1 4.2e-05 22.8 0.1 1.0 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein KR PF08659.10 CCF47828.1 - 5.6e-05 23.1 1.6 6.7e-05 22.9 1.6 1.1 1 0 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 CCF47828.1 - 0.00092 19.1 1.9 0.0013 18.6 1.9 1.3 1 1 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Epimerase PF01370.21 CCF47828.1 - 0.0043 16.6 0.3 0.0046 16.5 0.3 1.0 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family TrkA_N PF02254.18 CCF47828.1 - 0.0089 16.3 0.7 0.011 16.0 0.7 1.2 1 0 0 1 1 1 1 TrkA-N domain UDPG_MGDP_dh_N PF03721.14 CCF47828.1 - 0.011 15.4 0.3 0.011 15.3 0.3 1.1 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Urocanase PF01175.18 CCF47828.1 - 0.014 15.0 0.3 0.016 14.9 0.3 1.1 1 0 0 1 1 1 0 Urocanase Rossmann-like domain AdoHcyase_NAD PF00670.21 CCF47828.1 - 0.02 15.0 1.6 0.02 15.0 1.6 1.2 1 1 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 3Beta_HSD PF01073.19 CCF47828.1 - 0.043 12.8 0.1 0.052 12.6 0.1 1.0 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Tic110 PF16940.5 CCF47828.1 - 0.049 12.1 2.6 0.056 11.9 2.6 1.0 1 0 0 1 1 1 0 Chloroplast envelope transporter GDP_Man_Dehyd PF16363.5 CCF47828.1 - 0.085 12.2 0.1 0.087 12.2 0.1 1.0 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase 2-Hacid_dh_C PF02826.19 CCF47828.1 - 0.096 12.0 0.7 0.22 10.9 0.4 1.7 1 1 1 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Methyltransf_16 PF10294.9 CCF47828.1 - 0.11 12.2 0.1 0.11 12.2 0.1 1.2 1 0 0 1 1 1 0 Lysine methyltransferase Fibrillarin PF01269.17 CCF47829.1 - 6e-55 185.8 0.0 7.9e-55 185.4 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.10 CCF47829.1 - 0.16 11.7 0.1 0.23 11.1 0.1 1.1 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit Suf PF05843.14 CCF47830.1 - 0.0026 17.8 8.1 0.003 17.6 8.1 1.2 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) eIF-3_zeta PF05091.12 CCF47830.1 - 0.0068 15.4 1.0 0.0072 15.4 1.0 1.1 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) TFIIA PF03153.13 CCF47830.1 - 0.0069 16.4 22.3 0.0081 16.2 22.3 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF4834 PF16118.5 CCF47830.1 - 0.02 15.8 2.3 0.027 15.4 2.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) PAT1 PF09770.9 CCF47830.1 - 0.072 11.4 14.7 0.079 11.2 14.7 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Endostatin PF06482.11 CCF47830.1 - 0.074 12.5 4.2 0.083 12.3 4.2 1.2 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Spt20 PF12090.8 CCF47830.1 - 0.077 12.6 23.8 0.1 12.2 23.8 1.2 1 0 0 1 1 1 0 Spt20 family Connexin PF00029.19 CCF47830.1 - 0.081 12.7 0.2 0.098 12.4 0.2 1.1 1 0 0 1 1 1 0 Connexin DUF4175 PF13779.6 CCF47830.1 - 0.2 9.5 16.7 0.24 9.2 16.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Ndc1_Nup PF09531.10 CCF47830.1 - 0.27 9.9 3.8 0.32 9.6 3.8 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup EPL1 PF10513.9 CCF47830.1 - 0.37 11.2 6.0 0.5 10.7 6.0 1.2 1 0 0 1 1 1 0 Enhancer of polycomb-like Presenilin PF01080.17 CCF47830.1 - 0.91 8.2 4.7 1.2 7.9 4.7 1.1 1 0 0 1 1 1 0 Presenilin DUF2722 PF10846.8 CCF47830.1 - 0.97 8.3 21.0 1.3 7.9 21.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) DUF1387 PF07139.11 CCF47830.1 - 1.5 8.5 7.1 1.9 8.1 7.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Androgen_recep PF02166.16 CCF47830.1 - 6.1 5.6 27.4 8.3 5.1 27.4 1.2 1 0 0 1 1 1 0 Androgen receptor CVNH PF08881.10 CCF47831.1 - 2.9e-17 63.2 0.1 3.1e-17 63.1 0.1 1.0 1 0 0 1 1 1 1 CVNH domain Mtc PF03820.17 CCF47832.1 - 1.2e-118 395.7 0.0 1.4e-118 395.5 0.0 1.0 1 0 0 1 1 1 1 Tricarboxylate carrier zinc_ribbon_4 PF13717.6 CCF47833.1 - 0.026 14.4 0.4 0.049 13.6 0.4 1.5 1 0 0 1 1 1 0 zinc-ribbon domain DUF2407 PF10302.9 CCF47835.1 - 2.1e-29 102.1 0.0 3e-29 101.6 0.0 1.2 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain DUF2407_C PF13373.6 CCF47835.1 - 8.9e-08 32.4 0.4 1.3e-07 31.9 0.4 1.3 1 0 0 1 1 1 1 DUF2407 C-terminal domain ubiquitin PF00240.23 CCF47835.1 - 0.0014 18.4 0.0 0.0031 17.2 0.0 1.6 2 0 0 2 2 2 1 Ubiquitin family Rad60-SLD_2 PF13881.6 CCF47835.1 - 0.029 14.5 0.0 0.055 13.6 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Glyco_hydro_3 PF00933.21 CCF47836.1 - 1.6e-32 113.2 0.0 3.1e-32 112.2 0.0 1.4 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.22 CCF47839.1 - 2.3e-41 142.0 0.0 6.4e-41 140.6 0.0 1.8 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 CCF47839.1 - 3.1e-25 88.1 0.2 5.8e-25 87.2 0.2 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain Glyco_hydro_3 PF00933.21 CCF47839.1 - 9.1e-20 71.3 0.0 2.8e-19 69.7 0.0 1.7 2 0 0 2 2 2 1 Glycosyl hydrolase family 3 N terminal domain CARDB PF07705.11 CCF47839.1 - 0.011 16.0 0.0 0.029 14.6 0.0 1.7 1 0 0 1 1 1 0 CARDB NOA36 PF06524.12 CCF47840.1 - 0.033 13.5 16.2 0.035 13.4 14.7 1.7 2 0 0 2 2 2 0 NOA36 protein RNA_pol_3_Rpc31 PF11705.8 CCF47840.1 - 0.18 12.0 13.3 0.37 11.0 13.3 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Cwf_Cwc_15 PF04889.12 CCF47840.1 - 0.44 10.2 14.7 0.7 9.6 14.7 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein PBP1_TM PF14812.6 CCF47840.1 - 2 8.8 16.0 1.8 9.0 10.5 2.7 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal BUD22 PF09073.10 CCF47840.1 - 7.8 5.7 13.8 11 5.2 13.8 1.2 1 0 0 1 1 1 0 BUD22 Ribosomal_L34 PF00468.17 CCF47841.1 - 3e-14 52.7 10.8 6e-14 51.7 10.8 1.5 1 0 0 1 1 1 1 Ribosomal protein L34 Peptidase_M48_N PF16491.5 CCF47842.1 - 3e-67 226.1 8.2 3e-67 226.1 8.2 1.8 2 1 0 2 2 2 1 CAAX prenyl protease N-terminal, five membrane helices Peptidase_M48 PF01435.18 CCF47842.1 - 6.3e-45 153.4 0.1 1.1e-44 152.5 0.1 1.4 1 0 0 1 1 1 1 Peptidase family M48 Peptidase_M56 PF05569.11 CCF47842.1 - 0.045 12.9 0.0 0.095 11.9 0.0 1.6 1 0 0 1 1 1 0 BlaR1 peptidase M56 Ish1 PF10281.9 CCF47843.1 - 8.1e-05 22.9 0.1 0.00011 22.4 0.1 1.2 1 0 0 1 1 1 1 Putative stress-responsive nuclear envelope protein Mac PF12464.8 CCF47843.1 - 0.15 12.3 0.5 0.23 11.7 0.5 1.2 1 0 0 1 1 1 0 Maltose acetyltransferase DNA_meth_N PF18284.1 CCF47843.1 - 0.16 11.9 1.0 0.42 10.6 0.2 1.9 2 0 0 2 2 2 0 DNA methylase N-terminal domain Ribosomal_L38e PF01781.18 CCF47844.1 - 4.5e-33 113.2 2.6 5.2e-33 113.0 2.6 1.1 1 0 0 1 1 1 1 Ribosomal L38e protein family 3H PF02829.14 CCF47844.1 - 0.096 13.0 0.0 0.13 12.6 0.0 1.1 1 0 0 1 1 1 0 3H domain Cyclophil_like2 PF18050.1 CCF47844.1 - 0.11 12.5 0.0 0.2 11.6 0.0 1.4 2 0 0 2 2 2 0 Cyclophilin-like family ubiquitin PF00240.23 CCF47846.1 - 1.9e-19 69.2 0.0 2.9e-19 68.6 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD_2 PF13881.6 CCF47846.1 - 0.00014 21.9 0.0 0.00022 21.3 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD PF11976.8 CCF47846.1 - 0.00033 20.4 0.1 0.00054 19.7 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like STI1 PF17830.1 CCF47846.1 - 0.0024 17.7 13.2 0.11 12.5 3.5 2.6 2 0 0 2 2 2 2 STI1 domain DUF2407 PF10302.9 CCF47846.1 - 0.0028 18.2 0.0 0.0049 17.4 0.0 1.3 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Fungal_trans_2 PF11951.8 CCF47848.1 - 1.4e-05 24.1 0.8 0.00021 20.2 0.1 2.1 2 0 0 2 2 2 2 Fungal specific transcription factor domain Ketoacyl-synt_C PF02801.22 CCF47849.1 - 1.3e-39 134.9 0.0 2e-39 134.3 0.0 1.3 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain ketoacyl-synt PF00109.26 CCF47849.1 - 4e-09 36.4 0.1 7.7e-09 35.5 0.0 1.5 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Melibiase_2 PF16499.5 CCF47850.1 - 4.7e-26 91.6 3.4 1.4e-13 50.7 0.2 2.2 2 0 0 2 2 2 2 Alpha galactosidase A Melibiase_C PF17801.1 CCF47850.1 - 6.2e-12 45.4 0.3 1.2e-11 44.5 0.0 1.7 2 0 0 2 2 2 1 Alpha galactosidase C-terminal beta sandwich domain Sugar_tr PF00083.24 CCF47851.1 - 1.9e-98 330.2 26.8 2.3e-98 330.0 26.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF47851.1 - 1.2e-25 90.3 53.6 4.4e-23 81.8 26.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily COesterase PF00135.28 CCF47852.1 - 6.1e-57 193.6 3.9 3.1e-56 191.3 3.9 1.9 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CCF47852.1 - 0.005 16.7 0.3 0.055 13.3 0.3 2.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold DUF4360 PF14273.6 CCF47852.1 - 0.29 11.0 5.7 0.18 11.6 2.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4360) AAA PF00004.29 CCF47853.1 - 6.8e-13 49.2 0.0 1.3e-12 48.3 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CCF47853.1 - 0.00067 20.1 0.0 0.0018 18.7 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 CCF47853.1 - 0.0044 17.3 0.1 0.016 15.4 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 CCF47853.1 - 0.026 14.5 0.1 0.05 13.6 0.1 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) ATPase PF06745.13 CCF47853.1 - 0.047 13.0 0.1 0.074 12.4 0.1 1.3 1 0 0 1 1 1 0 KaiC MeaB PF03308.16 CCF47853.1 - 0.05 12.6 0.0 0.087 11.8 0.0 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_2 PF07724.14 CCF47853.1 - 0.068 13.3 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) NTPase_1 PF03266.15 CCF47853.1 - 0.075 12.9 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 NTPase AAA_18 PF13238.6 CCF47853.1 - 0.1 13.1 0.0 0.34 11.5 0.0 1.9 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 CCF47853.1 - 0.11 11.7 0.0 0.22 10.7 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin RuvB_N PF05496.12 CCF47853.1 - 0.19 11.4 0.0 0.34 10.6 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 CCF47853.1 - 1.9 7.8 3.5 1.5 8.2 0.1 2.4 2 1 0 3 3 3 0 Magnesium chelatase, subunit ChlI 2-Hacid_dh_C PF02826.19 CCF47855.1 - 3e-43 147.3 0.0 3.3e-43 147.1 0.0 1.0 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 CCF47855.1 - 3.5e-05 24.0 0.0 4.4e-05 23.7 0.0 1.1 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.12 CCF47855.1 - 0.027 14.0 0.0 0.033 13.7 0.0 1.1 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain AlaDh_PNT_C PF01262.21 CCF47855.1 - 0.038 13.3 0.0 0.044 13.1 0.0 1.1 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain PMT2_N PF17987.1 CCF47855.1 - 0.091 13.0 0.0 0.12 12.6 0.0 1.2 1 0 0 1 1 1 0 Phosphoethanolamine N-methyltransferase 2 N-terminal Shikimate_DH PF01488.20 CCF47855.1 - 0.093 12.8 0.0 0.36 10.9 0.0 1.9 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase DUF364 PF04016.12 CCF47855.1 - 0.097 12.3 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Putative heavy-metal chelation Methyltransf_23 PF13489.6 CCF47856.1 - 0.00025 20.9 0.0 0.00042 20.2 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Abhydrolase_1 PF00561.20 CCF47861.1 - 1.2e-13 51.3 0.0 1.8e-13 50.7 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCF47861.1 - 2.1e-09 38.3 0.0 2.5e-09 38.1 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCF47861.1 - 0.00042 19.6 0.0 0.00062 19.1 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.14 CCF47861.1 - 0.0057 15.4 0.0 0.0075 15.0 0.0 1.1 1 0 0 1 1 1 1 Ndr family PriCT_1 PF08708.11 CCF47861.1 - 0.071 12.8 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Primase C terminal 1 (PriCT-1) DUF3425 PF11905.8 CCF47862.1 - 5.1e-23 81.4 0.0 9.1e-23 80.6 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) p450 PF00067.22 CCF47863.1 - 2.5e-72 244.1 0.0 3.2e-72 243.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 TetR_C_8 PF14278.6 CCF47863.1 - 0.021 14.9 0.0 0.049 13.7 0.0 1.6 1 0 0 1 1 1 0 Transcriptional regulator C-terminal region Glyco_hydro_7 PF00840.20 CCF47864.1 - 2e-186 620.0 7.7 2.2e-186 619.8 7.7 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 7 DUF5013 PF16405.5 CCF47864.1 - 0.099 12.9 0.1 0.2 11.9 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5013) Pkinase PF00069.25 CCF47865.1 - 6.9e-68 228.9 0.0 8.6e-68 228.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF47865.1 - 5.5e-31 107.8 0.0 7.5e-31 107.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 CCF47865.1 - 0.00035 21.2 0.6 0.00088 19.9 0.6 1.8 1 0 0 1 1 1 1 Protein kinase C terminal domain FTA2 PF13095.6 CCF47865.1 - 0.026 14.1 0.0 0.9 9.1 0.1 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 CCF47865.1 - 0.054 12.4 0.0 0.1 11.6 0.0 1.4 1 1 0 1 1 1 0 Haspin like kinase domain Pkinase_fungal PF17667.1 CCF47865.1 - 0.13 11.0 0.0 0.26 10.0 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase MFS_1 PF07690.16 CCF47866.1 - 1.9e-27 96.2 32.6 1.9e-27 96.2 32.6 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF47866.1 - 1.9e-13 50.1 15.1 1.9e-13 50.1 15.1 1.8 2 1 0 2 2 2 1 Sugar (and other) transporter MFS_4 PF06779.14 CCF47866.1 - 0.00011 21.6 8.7 0.00011 21.6 8.7 2.8 2 1 1 3 3 3 1 Uncharacterised MFS-type transporter YbfB DUF3382 PF11862.8 CCF47866.1 - 4 7.8 10.0 3.2 8.1 0.1 4.1 2 1 1 4 4 4 0 Domain of unknown function (DUF3382) Beta_elim_lyase PF01212.21 CCF47867.1 - 1e-60 205.6 0.0 1.3e-60 205.1 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 CCF47867.1 - 7.2e-05 22.1 0.0 0.00015 21.1 0.0 1.4 1 1 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 CCF47867.1 - 9.9e-05 21.8 0.4 0.00026 20.4 0.4 1.7 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 CCF47867.1 - 0.0003 19.8 0.0 0.00041 19.4 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 CCF47867.1 - 0.0013 17.3 0.0 0.0031 16.1 0.0 1.5 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme WD40 PF00400.32 CCF47868.1 - 4.3e-35 119.2 21.6 1.6e-08 35.0 2.4 7.6 7 1 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF47868.1 - 1.2e-14 54.4 2.2 0.042 14.1 0.0 6.3 2 2 5 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain PRP4 PF08799.11 CCF47868.1 - 1.2e-13 50.3 2.1 2.1e-13 49.6 2.1 1.4 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like WD40_like PF17005.5 CCF47868.1 - 0.0033 16.8 0.0 0.91 8.8 0.0 3.0 3 0 0 3 3 3 1 WD40-like domain Nbas_N PF15492.6 CCF47868.1 - 0.0047 16.3 0.0 0.99 8.7 0.0 2.4 2 0 0 2 2 2 2 Neuroblastoma-amplified sequence, N terminal Ge1_WD40 PF16529.5 CCF47868.1 - 0.0077 15.2 0.0 6.1 5.7 0.0 4.2 2 1 4 6 6 6 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Cyclin_N PF00134.23 CCF47869.1 - 1.1e-07 31.7 0.5 0.00042 20.1 0.6 2.7 2 0 0 2 2 2 2 Cyclin, N-terminal domain TFIIB PF00382.19 CCF47869.1 - 0.1 12.7 0.2 0.18 11.9 0.2 1.3 1 0 0 1 1 1 0 Transcription factor TFIIB repeat Dus PF01207.17 CCF47870.1 - 9.5e-31 107.0 0.0 1.4e-26 93.3 0.0 2.4 2 1 0 2 2 2 2 Dihydrouridine synthase (Dus) SpoIIE PF07228.12 CCF47871.1 - 6.1e-09 36.1 0.0 1.2e-08 35.1 0.1 1.5 2 0 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) PP2C PF00481.21 CCF47871.1 - 5.6e-07 29.4 0.2 0.027 14.1 0.0 2.4 2 0 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 CCF47871.1 - 1.2e-05 25.1 1.3 2.5e-05 24.0 1.3 1.5 1 1 0 1 1 1 1 Protein phosphatase 2C eIF-6 PF01912.18 CCF47872.1 - 4.5e-18 65.4 0.2 8.2e-18 64.5 0.1 1.4 2 0 0 2 2 2 1 eIF-6 family HupE_UreJ PF04955.12 CCF47872.1 - 0.069 12.6 0.0 0.09 12.2 0.0 1.1 1 0 0 1 1 1 0 HupE / UreJ protein Spc7 PF08317.11 CCF47873.1 - 0.002 17.1 10.3 0.0034 16.3 10.3 1.3 1 0 0 1 1 1 1 Spc7 kinetochore protein MAD PF05557.13 CCF47873.1 - 0.012 14.0 7.9 0.093 11.1 8.3 1.9 2 0 0 2 2 2 0 Mitotic checkpoint protein Golgin_A5 PF09787.9 CCF47873.1 - 0.016 14.7 9.8 0.024 14.1 9.8 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 Macoilin PF09726.9 CCF47873.1 - 0.036 12.6 2.5 0.052 12.1 2.5 1.2 1 0 0 1 1 1 0 Macoilin family Atg14 PF10186.9 CCF47873.1 - 0.048 12.7 2.4 0.096 11.8 2.4 1.5 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Fib_alpha PF08702.10 CCF47873.1 - 0.25 11.5 3.0 0.41 10.8 2.2 1.8 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family ZapB PF06005.12 CCF47873.1 - 1.6 9.2 12.6 3.6 8.1 0.0 3.0 2 1 1 3 3 3 0 Cell division protein ZapB DUF2570 PF10828.8 CCF47873.1 - 3.5 7.5 6.6 2.6 7.9 4.8 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2570) TMPIT PF07851.13 CCF47873.1 - 5.5 6.1 5.1 8.2 5.6 5.1 1.1 1 0 0 1 1 1 0 TMPIT-like protein NDUF_B12 PF08122.12 CCF47874.1 - 1.2e-24 86.1 1.4 1.6e-24 85.7 1.4 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B12 subunit family CAF1 PF04857.20 CCF47875.1 - 1.6e-22 80.1 0.1 1.4e-10 40.9 0.0 2.1 2 0 0 2 2 2 2 CAF1 family ribonuclease RFX_DNA_binding PF02257.15 CCF47875.1 - 0.08 13.6 0.0 0.48 11.1 0.0 2.1 2 0 0 2 2 2 0 RFX DNA-binding domain LMBR1 PF04791.16 CCF47876.1 - 1.6e-109 367.2 5.2 1.8e-109 367.0 5.2 1.0 1 0 0 1 1 1 1 LMBR1-like membrane protein DUF2040 PF09745.9 CCF47877.1 - 3.3e-39 133.7 24.4 3.3e-39 133.7 24.4 3.3 3 1 0 3 3 3 1 Coiled-coil domain-containing protein 55 (DUF2040) zf-Tim10_DDP PF02953.15 CCF47878.1 - 8.4e-22 76.6 1.2 1e-21 76.3 1.2 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Lectin_leg-like PF03388.13 CCF47879.1 - 2.7e-66 223.2 0.0 3.3e-66 222.9 0.0 1.1 1 0 0 1 1 1 1 Legume-like lectin family Lectin_legB PF00139.19 CCF47879.1 - 8.8e-05 22.2 0.0 0.43 10.1 0.0 2.1 2 0 0 2 2 2 2 Legume lectin domain Pkinase PF00069.25 CCF47880.1 - 1.2e-75 254.3 0.4 2.8e-75 253.1 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF47880.1 - 1.4e-38 132.7 0.0 2.3e-38 131.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF47880.1 - 2.7e-08 33.5 0.6 9.5e-08 31.7 0.0 2.0 2 0 0 2 2 2 1 Kinase-like TFIIA PF03153.13 CCF47880.1 - 0.023 14.7 37.9 0.032 14.2 37.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit APH PF01636.23 CCF47880.1 - 0.17 11.7 1.5 0.85 9.5 0.0 2.2 2 0 0 2 2 2 0 Phosphotransferase enzyme family CorA PF01544.18 CCF47881.1 - 0.00016 21.1 3.2 0.00031 20.2 2.1 2.0 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein COX16 PF14138.6 CCF47881.1 - 0.031 14.8 0.1 3.3 8.3 0.0 3.1 2 1 0 2 2 2 0 Cytochrome c oxidase assembly protein COX16 EMP70 PF02990.16 CCF47881.1 - 0.15 10.7 0.0 0.22 10.2 0.0 1.2 1 0 0 1 1 1 0 Endomembrane protein 70 PI-PLC-X PF00388.19 CCF47882.1 - 3e-63 211.7 0.0 4.4e-63 211.2 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 CCF47882.1 - 2.9e-41 140.4 0.0 5.2e-41 139.6 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain VGLL4 PF15245.6 CCF47882.1 - 0.091 12.8 0.1 0.18 11.9 0.1 1.4 1 0 0 1 1 1 0 Transcription cofactor vestigial-like protein 4 # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Colletotrichum_higginsianum-ASM31379v2/GCA_000313795.2_ASM31379v2_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Colletotrichum_higginsianum-ASM31379v2/GCA_000313795.2_ASM31379v2_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Colletotrichum_higginsianum-ASM31379v2/GCA_000313795.2_ASM31379v2_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Colletotrichum_higginsianum-ASM31379v2/GCA_000313795.2_ASM31379v2_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Sun Mar 24 19:14:11 2019 # [ok]